RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'RF-enhanced Microprocessing for Fine Chemicals Synthesis using Catalysts Supported on Magnetic Nanoparticles' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This proposal aims at further strengthening the current line of the applicant’s research in the area of nontraditional energy sources and structured reactors. Novel and challenging reactor concepts and technologies are proposed for newly emerging liquid phase catalytic processes for, amongst others, fine chemicals and pharmaceuticals synthesis. Catalytic processes in the liquid phase are crucial in the manufacturing of fine and specialty chemicals. It is widely accepted that the activity of a solid catalyst suspended in a liquid phase can benefit greatly from the use of smaller catalyst particles to avoid mass-transfer limitations. However, the difficulties in recovering small particles from the reaction mixture severely circumvent their industrial applications. To overcome the above drawbacks, the separation of suspended magnetic catalyst bodies from the liquid system using an external magnetic field is proposed. Functionalized magnetic bimetallic nanoparticles are leading candidates for catalytic applications as a vector for magnetic guidance. Their appclication will provide reactors and processes for synthetic routes and high-value added products with optimal space-time yields, minimum waste production, minimum energy consumption, and minimum operating costs. Two novel reactor concepts are proposed in this ERC starting grant program with the aim to develop and demonstrate continuous flow reactors, viz. (1) the RF-heated reactor where catalytically active magnetic nanoparticles are hold in the reactor by an external magnetic field while being heated, and (2) the micro-flow through reactor for magnetic NP manipulation, where mixing in laminar flow is improved by quadrupolar actuation created by a quadrupolar micro magnet arrangement along the channel.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Demonstrating energy intensive industry-integrated solutions to produce liquid renewable energy carriers from CAPTUred carbon emissionS' (CAPTUS) under Horizon Europe.

assistant: **Objectives**

GHG emissions reduction policies to mitigate climate change heavily impact on energy intensive industries, leading to loss of employment and competitiveness. In addition, variable renewable generation faces high risks from electricity curtailment if renewable surplus is not used. Carbon capture and utilisation technologies that make use of industrial flue gas and renewable surplus will play a key role in the clean energy transition of industry. Various technologies exist but most are still quite demanding in terms of materials and energy, being costly and inefficient. CAPTUS key objective is to demonstrate sustainable, cost-effective and scalable pathways to produce high-added value energy carriers by valorising industrial carbon emissions and integrating renewable electricity surplus. To this end, 3 complete value chains will be demonstrated at 3 different demo-sites: (i) Bioprocess based on a two-stage fermentation to produce triglycerides in a steel plant, (ii) Lipids-rich microalgae cultivation followed by hydrothermal liquefaction to produce bio-oils in a chemical plant, and (iii) Electrochemical reduction of CO2 to produce formic acid in a cement plant. The proposed technologies will be tested at TRL7, and the obtained energy carriers will be validated by upgrading studies. CAPTUS will also validate solutions regarding economic, environmental, societal and geo-political criteria, contributing to the development of novel business models, guidelines and strategies. CAPTUS has been structured in 8 WP, combining R&D activities, project management and demonstration activities. CAPTUS addresses this complex challenge by gathering a competitive consortium of 18 partners from 8 EU countries. Overall, CAPTUS innovations at technical, economical, managerial and social level
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'African Union Soil Observatory' to be submitted under Horizon Europe.

assistant: **Abstract**

Africa's soils are in crisis, with widespread degradation threatening agricultural productivity, biodiversity, and water regulation. Unsustainable farming practices, climate change, and population growth exacerbate this issue, leading to reduced crop yields, food insecurity, and economic hardship for millions. Women and youth are particularly affected, facing increased workloads and limited educational and economic opportunities. Addressing these challenges requires accurate and accessible soil health data, which is often unavailable or hard to obtain across the continent. This hampers policymakers and researchers in monitoring soil conditions, tracking changes, and implementing targeted interventions.The AUSO project aims to tackle these issues by establishing a continental African Union Soil Observatory (AUSO), which includes an African Soil Data Center (ASDAC) and a Soil Health Dashboard to fill existing data gaps. Managed by FARA and owned by the African Union Commission, the AUSO will consolidate soil data from various national and international sources, creating a user-friendly platform for soil health monitoring. Through efforts to address data shortages and develop national soil health strategies in 12 countries, AUSO will empower stakeholders in the public and private sectors to make informed decisions, prioritize interventions, and support evidence-based soil and land management policies that promote sustainable agriculture.AUSO will build on the Soils4Africa SIS and draw insights from the EU Soil Observatory and other initiatives, ensuring relevance and adaptability to the African context. The project will adopt a co-development approach, engaging stakeholders from national agricultural institutes, government departments, and other key organizations.


**Keyw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Role of perforin-like proteins and phospholipases in malaria parasite egress' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The malaria parasite Plasmodium falciparum, which causes ~600,000 deaths annually, propagates within host erythrocytes. Roughly synchronous egress of blood stage parasites in vivo causes the periodic fevers associated with malaria and is essential for parasite replication. Blocking parasite egress can stop disease progression, so understanding its mechanism is key to identifying new drug targets. Egress of malaria parasites from host erythrocytes involves the rupture of two membranes- the parasitophorous vacuole membrane and the erythrocyte membrane. It is unclear how the parasitophorous vacuole membrane ruptures during egress, and what mechanism is responsible for poration of the erythrocyte membrane. While it has been shown that egress is protease-dependent, the effector molecules that bring about the disruption of both membranes remain unknown. Potential effector molecules include parasite perforin-like proteins (PLPs) and phospholipases.  This project aims to test the hypothesis that Plasmodium PLPs and phospholipases are involved in malarial egress. First, we will apply newly developed conditional knockout strategies to establish the role in egress of a candidate perforin-like protein. Second, we aim to devise a novel conditional genetic screen to identify egress related phospholipases in a medium-throughput manner. This work will add to the efforts being made to understand egress and will attempt to develop a much needed forward genetic screen in the malaria parasite. The interdisciplinary approach proposed here combines the experienced researcher (ER)’s skills in genomics and the host laboratory’s expertise in malarial cell biology and conditional knockout technologies. This will equip the ER with the right exposure and new skills to pursue a future independent r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nanowire-based one-dimensional electronics' (NODE).

assistant: **Innovation**

NODE focuses on an innovative bottom-up approach to fabrication and integration of nanoelectronic devices, based on self-assembling semiconductor nanowires. The primary target is to deliver replacement and add-on technologies to silicon CMOS, such as FET devices for logics and III-V bipolar transistors for RF applications. NODE will study key device families based on semiconductor nanowires, assess their compatibility with conventional semiconductor processing, and evaluate novel architectural concepts and their implementation scenarios.It is the overall objective of the NODE Integrated Project to demonstrate that nanowire-based device technology is the disruptive technology needed for long-term innovation and growth in the electronics industry. NODE hereby takes on the challenge as formulated in the IST Work Programme: breaking new barriers with current CMOS technology below 10 nanometres as well as the exploration of alternative materials". The partners are leading academic groups in nanowire research and semiconductor nanofabrication, research laboratories from major European electronics industries (Philips, IBM and Infineon), an SME-company specialized in nanowire device technology (QuMat), as well as a major European Si-technology research centre (IMEC). This coverage of the entire science-technology-application chain among the partners ensures early access for the European electronics industry to the knowledge generated within NODE, and maximizes the likelihood of effective exploitation of its results.At the end of the project, a selection of the most promising nanowire technologies will have been made and the incorporation of nanowire devices into Si-technology demonstrated. It is further expected that the knowledge gained will support other European science and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Hierarchically Organized Metal Organic Catalysts for Continuous and Multi-batch Processes'.

assistant: **Objectives**

Hierarchically organised metal organic catalysts shall be developed which can be easily recycled in multi-batch processes or which can be used in continuous processes without loosing the original advantages of the corresponding homogeneous soluble metal organic catalysts - high selectivity, activity and stability. The catalysts will be constructed using components at the nano-scale in a bottom-up approach. Hereby, catalytically active metal complexes will be linked with nanoparticles such as polymeric microgels, hyperbranched polymers or hybrid systems consisting of silsesquioxanes attached to hyperbranched polymers. Further hierarchical organisation of HiCat catalysts will be accomplished by interconnected networks formed from the assemblies of catalytic nanoparticles using end-functional T-responsive polymers that can interact with functionalities on the surface of the nanoparticles as binding agents. Recycling of the catalyst-nanoparticle entities in multi-batch operation will be studied utilizing the change of solubility of the polymer supported catalysts by external stimuli. Based on polymer-nanoparticles linked by T-responsive polymers, new types of films and membranes with graded porosity can be prepared by varying the size of the nanoparticles and the length of T-sensitive polymers. This opens new opportunities for integration of catalytic steps and separation within the hierarchically structured system and, hence for continuous reactor operation. The proposal combines the superiority of homogeneous metal-organic catalysts often possessing nearly 100 % selectivity with the advantage of efficient separation by grabbing a new concept for building up hierarchically organised catalytic systems. Structural principles of tailor-made ligands will be transferred into ta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Future Leadership in ICT Standards in Europe “ELITE-S”' (ELITE-S).

assistant: **Innovation**

ICT standards play an essential role in achieving interoperability of new technologies and can bring significant benefits to both industry and consumers. They support the realisation of a European Digital Single Market and allow consumers and businesses the widest choice of products and services across the EU. DCU, host to the ADAPT Centre, is an international hub of scientific expertise related to ICT standards in areas such as data and regulation technologies, data privacy and protection, content analytics, machine learning, preservation, personalisation and interoperability, data and process management. ADAPT will host the ELITE-S Programme which will offer 16 prestigious two-year fellowships for incoming mobility across three calls over the 72 months duration of the programme.Fellowships will be offered in the four core research areas Regulations and Compliance, Content Analytics and Content Preservation, Data and Process Management, Interoperability. ELITE-S applicants will have the freedom to choose their own research topic, their supervisor and their secondment host. The ELITE-S programme will offer excellent quality in the selection of researchers, and high quality training, supervision and training in transferable skills. Specifically:-Provide a state of the art research environment in the area of ICT standardisation related to the programme's core research areas that will stimulate and challenge researchers while developing them as research leaders of the future-Provide fellows with industry-specific training and secondments in priorities sectors including 5G, Internet of Things, Cloud computing, cybersecurity and data technologies-Implement a transparent evaluation and selection process for recruitment-Provide an attractive and supportive working environment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Neuromorphic Polariton Accelerator' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Exciton-polaritons, hybrid light-matter particles, have recently come into the spotlight for their peculiar properties (sizable interaction, small mass, long coherence, etc.) leading to spectacular effects such as phase transitions, superfluidity, bistability, ultra-efficient fourwave-mixing, and quantum blockade. On the other hand, polaritons have also been proposed for different kinds of devices (including optical switches, transistors, low threshold lasers and simulators), with beautiful experiments showing proofs-of-principle. However, it is only recently that polaritons have been operating efficiently at room temperature, giving the promise of a real technological impact in the future. In a recent work, made by some of the theoretical and experimental partners of this proposal, we could demonstrate that such hybrid state of matter, when used for realising artificial neural networks, shows extremely interesting performances in terms of speed and success rate.Given the strong interest in the realisation of hardware-based (not simulated) artificial neural networks, the goal of PolArt is to demonstrate a new way to build artificial intelligence-dedicated circuits using polariton neural networks as optical accelerators.Thanks to this new concept device, complex applications related to neural-like processing, will be efficiently implemented, therefore enabling neuromorphic computation to be done in small devices that cannot rely on remote, large bandwidth connection. This proposal benefits from the contribution of several complementary partners coming from many different research areas (material science, physics, optics, chemistry, genetics) and industrial participants that assure the interdisciplinarity and technological oriented target.


**Keywords:** Polaritons, exci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Medicinal Chemistry Open Innovation Doctorates', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The establishment of influential public and private public partnerships fostering true collaboration between big Pharma and universities for a non-profit end goal has opened the door for stronger interaction and integration. This structural change has come to stay and is slowly permeating other sectors in which the commercial return on investment is clear (Drug. Discov. Today, 2009, 14, 1003). This new paradigm is also creating opportunities for young scientists to experience and understand both industrial and academic points of view when it comes to the early discovery and pharmaceutical development of new drugs. A new generation of scientists trained under a public-private partnership will find itself in a privileged position in terms of employment opportunities. Moreover, the close ties arising from this interaction will improve the dialogue between Pharma and academia, resulting in faster implementation of relevant medicinal chemistry basic science discoveries into the Pharma pipeline and a better understanding within academia of the critical limiting factors behind falling productivity in the Pharma sector.In this context, neglected diseases research and development is opening important new avenues of collaboration between academia and industry. The scientific focus of this EID project will be on the design and synthesis of novel antituberculosis drugs. The fellows will have unique access to corporate HTS screening hits while being exposed to both industrial and academic med chem strategies and philosophies. These chemical efforts will be supported by the application of state of the art chemical biology tools for investigation of compound activity profiles. In particular, the new single cell microfluidic-microscopy system at the industrial partner´s site will allow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'CamoUflaged nanopaRticle-driven duAl Therapy to eradicate aggressIVe nEuroblastoma' in the context of a Horizon Europe call.

assistant: **Objectives**

Neuroblastoma (NB) is a highly aggressive paediatric cancer, accounting for 15% of childhood cancer deaths. The 5-year survival rate for high-risk NB patients is less than 50%. Despite the significant advances in treatment options, the high tumour heterogeneity, drug resistance, and severe toxicities associated with conventional therapies continue to result in poor outcomes for high-risk NB patients. Recent studies showed that these challenges, along with frequent relapses, may be linked to the intrinsic resistance of a specific population of cells known as cancer stem cells (CSCs). CURATIVE aims to address this by developing a chitosan-based nanoparticle (NP) that co-encapsulates a systematically identified and optimized synergistic combination of drugs designed to target both CSCs and a key mechanism driving NB progression. The NP, which will enable controlled and sustained drug release, will be coated with plasma membranes derived from NB cells to enhance tumour targeting and accumulation through homotypic targeting. By leveraging the innovative use of NB cell membranes, the NP can closely mimic the tumour environment, allowing it to evade the immune system and preferentially accumulate at the tumour site. This approach enhances both specificity and efficacy, while simultaneously reducing off-target effects and minimizing systemic toxicity. The expected outcomes of CURATIVE include increased survival and treatment efficacy, reduced relapse rates and toxicity, and improved quality of life for paediatric patients. Overall, CURATIVE is positioned to provide valuable insights and resources to the scientific community, supporting the EU's objectives of advancing innovation in paediatric cancer care.


**Keywords:** Neuroblastoma, nanomedicine, pediatric cancer therapy