RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Agile Photonic Integrated Systems-on-Chip enabling WDM Terabit Networks' (APACHE) under Seventh Framework.

assistant: **Objectives**

The APACHE project will develop new compact, scalable and cost-optimized photonic integrated components that will be capable of generating, regenerating and receiving amplitude- (OOK) and phase- (DPSK, QPSK) encoded optical signals for high capacity (>100Gb/s) WDM networks. The APACHE concept is based on developing devices having both multi-functionality and agility in order to reach Terabit capacities on a single photonic integrated chip. The technology is based on the combination of indium phosphide monolithic elements, silicon submounts and silica-on-silicon planar lightwave circuits for achieving cost-effectiveness, high yield, small footprint, low power consumption and device scaling far in advance of the level commercially available today. The APACHE integration approach includes an increase in scale for both horizontal and vertical integration through a monolithic-on-hybrid" technology. Horizontal integration (the serial increase in the number of and type of components hybridly integrated) will be implemented using low loss passive assembly. Using this technique, the integration of different photonic elements such as lasers, amplifiers, modulators and filters will be achieved. In parallel, vertical integration (increasing the complexity of the optical components from single function devices to large arrays using monolithic InP integration, which are also subsequently hybridly integrated) will provide a scaleable and low cost platform for the realisation of compact and low power consumption modules. Phase and amplitude modulators (EAM, MZIs and nested MZIs) will be fabricated exploiting InP technology, opposed to lithium niobate (LiNbO3), for achieving at least a factor of twenty in footprint reduction, lower driving voltages and increased stability. APACHE will i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Frugal Artificial Intelligence and Application in Astrophysics'.

assistant: **Objectives**

Beneath the amazing colors of the beautiful images collected by telescope facilities in space and on remote mountaintops lie numbers, and lots of them. These data contain the scientific information astronomers need in order to reveal the physical properties of the Universe and the laws that govern its function. Recent advances in detector technologies and large focal plane CCD arrays enable astronomers to efficiently monitor a hyperspectral/multiwavelength view of the sky, thus opening the last unexplored window, the one of time domain in short time scales. This ability of daily monitoring big swaths of the sky over extended periods produces astronomical datasets at an astounding rate, revealing the transient and often violent face of the Universe. Hence, researchers need to develop more powerful computational and statistical methods to tackle the data, to get the big picture view out of the underlying science details.  The TITAN project will appoint an outstanding researcher as the ERA Chair holder of Astroinformatics to incept and lead a research program in computational astrophysics and data science, which will couple, transform and expand two major research operations at FORTH - Computer Science and Astrophysics - while rooting an effective bridge between regional research excellence and international missions. Our grand vision is to create a true interdisciplinary, international and multicultural center of excellence for developing the tools, methods, and applications of computational science, machine learning, and statistics for research and education in data-oriented Astronomy. TITAN will fully unlock the potential of FORTH, the Cretan region and Greece through the implementation of a set of measures geared towards: capacity building (expansion of the research pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European Renal Genome Project' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Diseases of the kidney represent a major cause of morbidity and mortality in Europe. The elderly are disproportionately affected, but renal disease is also a condition that severely affects children. An estimated 4.5 Million Europeans suffer from renal disorders. The death rate in patients with renal failure is 20% annually. This disease burden and its challenge for our societies is the focus of this proposal. Elucidation of the human and other genomes heralds a new era in biomedical research offering unprecedented opportunities to understand disease processes and to identify strategies to improve health. We will embrace these opportunities and implement an interdisciplinary research program, the European Renal Genome Project (EuReGene) that integrates European excellence in research relevant to renal development, pathophysiology and genetics. Our goal is to discover genes responsible for renal development and disease, their proteins and their actions. To achieve this goal, we have established a consortium of leading scientists, clinicians and SME partners that will focus on the development of novel technologies and discovery tools in functional genomics and their application to kidney research. We will rely on comparative genomic studies in many systems that provide utilitarian models ranging from zebrafish, to Xenopus, to mice, to rats. Our studies will be performed at different levels including the gene, the cell, the organ and the organism. Ultimately, identification of disease genes will lead to a better understanding of renal disease processes, to improved diagnosis and to new concepts in therapy. Our program will establish a paradigm for an integrated post-genomic approach to analyze renal disease-related developments that may be transferred to other organ system
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role of Palmitoylation ERASERs in cancer metastasis' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Metastasis is the major cause of death in patients with cancer. A better understanding of the mechanisms driving metastasis is critical to develop more effective anti-cancer treatments. The fatty acid palmitate has been recently identified as fuel for metastasis-promoting pathways. However, why palmitate has such a unique pro-metastatic effect compared to other fatty acids with similar metabolic fates remains elusive. Strikingly, I discovered that palmitoylation, a reversible post-translational protein modification driven solely by palmitate, is essential for metastasizing breast-cancer cells. Unexpectedly, I found that palmitoylation ‘erasers’, enzymes that remove the modification, are essential to sustain pro-metastatic effects of palmitate during metastatic colonization. Therefore, I hypothesize that, in palmitate-rich conditions (e.g under high-fat diet), palmitoylation anchor oncogenic proteins to membranes to get activated (functioning as a priming event), while erasers act as a rate-limiting release step, allowing primed proteins to engage in pro-metastatic signaling. I will investigate how the dynamics of palmitoylation promote metastasis by focusing on the erasers, whose role in metastasis remains largely unexplored. Specifically, I will: 1) define how erasers influence pro-metastatic signaling events in metastasizing cells; 2) investigate how erasers activity is regulated in metastasizing cells; and 3) assess how organ microenvironments and palmitate-rich diet condition eraser activity. I will address this by integrating multi-omics, molecular biology and mass spectrometry techniques with clinically relevant in vivo metastasis models. PalmERASERs will serve as a proof of concept for palmitoylation-based therapies with the goal of preventing or treating metasta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced numerical modeling techniques and design of metasurface-based components for 5G communications' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The value of the global 5G services market is expected to grow to $249.2 billion by 2026. The considerably increased resources required (i.e. greater spectral bandwidth, greater throughput, lower latency) have already led to the transition of telecommunication channels at higher frequency bands, where the design and utilization of artificially resonant materials, metamaterials, and their two-dimensional equivalents -metasurfaces- has emerged. Metasurfaces, the lightweight, easy-to-fabricate artificial sheet structures composed of subwavelength particles, exhibit unique electromagnetic properties of effectively controlling and manipulating the wave propagation and constitute the enabling technology for the design of mm-wave components. Fully planar waveguiding structures, beam-steerable leaky wave antennas, perfect absorbers are only a few applications of the emerged metasurface concept. Furthermore, increased requirements of multi-Gbps systems have already given a boost to reconfigurable designs of components via electronic tuning of their parameters. BEYOND META will provide a significant contribution to the wireless and mobile telecommunications sector, focused on the field of antennas and propagation, by developing a robust and powerful computational tool for the analysis, design, fabrication and measurement of metasurfaces, as an enabling technology for the production of novel components in the mm-wave region, in order to be incorporated in 5G communications systems, according to the industry demands. Special emphasis will be given on reconfigurability of innovative structures (antennas and absorbers), via application of electronically tunable mechanisms. The realization of these specific objectives will be performed by the researcher at the Section for Electromagne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Structure-function relationship of pectins and pectolytic enzymes' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Europe has a dominating role in industrial production of pectins and pectolytic enzymes. The major pectin suppliers are EU-based companies. Where present pectin technology uses inorganic acids and bases for extraction, purification and hydrolytic modification, the use of specific and pure enzymes for these purposes promises: Better control of functional properties of pectin in existing applications, and widening of the functional properties of pectins and thereby the fields of applications. Thereby, and through the growing preference for pectin as a functional food ingredient with positive nutritional effects, it is expected, that the growth in pectin consumption will increase. To realise the full effect of these prospects it is necessary to further strengthen the fundamental research into the molecular structure of pectin, and into existing and new pectolytic enzymes and their effect on pectins. Therefore, 6 EU-based scientific centers and an EU-based manufacturer of pectins and pectolytic enzymes have jointly drafted the present research proposal. The first objective of this proposal is to develop new and better qualitative and quantitative methods to determine the structure of pectins from apple, citrus and other suitable plant materials, using the latest developments in analytical techniques and apparatus. Two complementary strategies will be followed: i) Enzymatic fingerprinting through use of a range of pure pectolytic enzymes. The pectin polymers will be degraded and the resulting fragments separated by HPLC followed by analysis on NMR, MS and Laser-Desorption MS in order to generate fingerprints correlating to specific pectin structures. ii) Development of Anti-pectin antibodies: The antibodies will be used to characterize the pectin- polymer with respect to sub
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Humanities Rocks! Science on stage in Ljubljana for 100 years' under Horizon 2020.

assistant: **Concept**

The objective of HUMANITIES ROCK is to bring researchers closer to the general public and to increase awareness of research and innovation activities, with a view to supporting the public recognition of researchers, creating an understanding of the impact of researchers' work on citizen’s daily life, and encouraging young people to embark on research careers. The University of Ljubljana consists of 26 faculties and academies from all fields of science, will celebrate 100 years of its existence next year. Despite well-established communication with the public in the past, particularly humanities are becoming marginalized, if not neglected, not only in the increasingly commercialized public space, but also within the research. The general disvalue of research importance is partly a consequence of the misperception of the researchers’ work, persisting stereotypes and underestimation of the role of research results for improving the quality of life for everyone. With the activities and events on 28 September 2018 in 27 September 2019, we are aiming to improve the perception and reputation of researcher profession in public and their work. The event will target the public at large: children and youth, families and older people. The preceding awareness campaign will comprise the public competition among young people, the accompanying researchers` presentations in schools across Slovenia and the establishment of personal contacts with media representatives.  The researchers will be the stars of the night, but at the same time they will be presented on stage as ordinary people with extraordinary jobs. The HUMANITIES ROCK! project will offer many different and attractive events and activities in Ljubljana for children and students, families and adults. The proposed activities ar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Efficient mixing method at the microscale for Time-Resolved Serial Femtosecond Crystallography', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

X-MIXING is an interdisciplinary project aimed at conceiving an efficient mixing method at the microscale suitable for triggering not-light sensitive biochemical reactions in the application of Time-Resolved Serial Femtosecond Crystallography. Nowadays, the temporal resolution of this type of dynamic structural biology analysis with X-ray Free-Electron Lasers is limited by the minimum mixing time that current methods can produce. As it is shown in a proof-of-concept, an exciting combination of electrohydrodynamic fields and momentum transfer lead to a significant variation of the spatiotemporal scales within the convection-diffusion mechanism. So, this configuration can potentially generate mixing from 100 to 1000 faster than current means do.  Besides, its versatility would enable not only to reduce the mixing time substantially, but also to induce jumps in PH and temperature that would additionally open horizons concerning new types of triggering reactions in the field. These critical features have the potential to become this original configuration in a key to take full advantage of the recent significant investment, over 1,22 billion euro (2005 value), paid by European Union and partners for the construction of the European XFEL (Germany), whose user operation started in September 2017. To explore and elucidate the underlying physical limits of the proposed method, the research methodology of this project will embrace different approaches such as micro-PIV experiments, numerical simulations, and scaling analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Newtinst ew' (1998-2002).

assistant: **Innovation**

The Isaac Newton Institute for Mathematical Sciences is a international institute which covers the broad spectrum of mathematical sciences. During 2000 the institute will hold a number of interdisciplinary programmes and it is intended that one Euro Workshop take place during several of these.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'STEM CELL MODELS TO UNRAVEL THE SUSCEPTIBILITY AND RESILIENCE TO DEVELOP HEART FAILURE' (STOP-HF) targeting Horizon 2020.

assistant: **Abstract**

The overarching objective of STOP-HF is to generate human induced pluripotent stem cells (hiPSC) derived cardiomyocytes from two specific forms of heart failure (HF) with a clear trigger to unravel common pathophysiological mechanisms involved in the early development of HF. The project is focused on two specific forms of HF, both with a clear trigger: pregnancy and anthracyclines. Better understanding of early molecular pathways leading to HF and knowledge about inter-individual susceptibility is needed. For detection of early changes on a molecular level cardiac tissue is needed. Generation of patient specific cardiac cells from skin fibroblasts (hiPSC technology) is a novel and innovative approach.SPECIFIC OBJECTIVES 1. Fabrication and maturation of 3D cardiac tissue from hiPS derived cardiomyocytes.2. Generate and characterize hiPS derived cardiomyocytes and endothelial cells from females with pregnancy induced HF and unravel differences on transcriptome level.3. Generate and characterize hiPSC derived cardiomyocytes from patients with high susceptibility and resilience to develop anthracycline-induced HF and compare them on transcriptome level. 4. Integrate the results for coding and non-coding RNAs from objective 1+2 and identify overlapping pathways. 5. Validate discoveries on transcriptome level in vitro, in vivo and apply for the development of HF in the general population.WORKPACKAGESWP1: Optimize fabrication and maturation of 3D cardiac tissue from hiPS derived cardiomyocytesWP 2A:Validate the model and compare hiPS derived cardiomyocytes and endothelial cells from PPCM and healthy sisters on transcriptome level;WP 2B:Validate the model and compare hiPS derived cardiomyocytes from both patients with high susceptibility and resilience to develop HF after anthr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Brain growth under social pressure: mathematical modelling of brain growth when individuals face social challenges' (SocialBrain).

assistant: **Concept**

Growing and maintaining a large brain entails substantial energetic costs. A large brain can evolve if costs are compensated by benefits from associated cognitive abilities. Leading hypotheses for brain evolution consider benefits arising from the solution of ecological and social problems. However, progress has been hindered by the unavailability of mathematical theory generating testable hypotheses from known causes.I will develop testable mathematical models that yield quantitative predictions for brain mass through ontogeny when individuals evolve under social pressures. The goal is to assess the relative role of the social and ecological hypotheses in brain evolution, particularly in humans. I will formulate the models using elements of metabolic theory and life history theory, and the analysis will require methods from optimal control and differential game theory.This is a strongly interdisciplinary research project, and I will ensure its success by working with leaders in the respective fields of social evolution theory (Dr Andy Gardner, St Andrews), cognition (the world-class multi-departmental team at St Andrews), and differential game theory (Prof Maurizio Falcone, Sapienza). This work thus brings together a diversity of state-of-the-art elements and proposes an innovative, challenging, and important project, to produce a novel and readily usable tool to study brain evolution.


**Keywords:** Brain evolution, evolutionary biology, life history, mathematical modelling, differential games, metabolic theory of ecology