RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Rounding the circle: Unravelling the biogenesis, function and mechanism of action of circRNAs in the Drosophila brain.' to be submitted under Horizon 2020.

assistant: **Abstract**

Tight regulation of RNA metabolism is essential for normal brain function. This includes co and post-transcriptional regulation, which are extremely prevalent in neurons. Recently, circular RNAs (circRNAs), a highly abundant new type of regulatory non-coding RNA have been found across the animal kingdom. Two of these RNAs have been shown to act as miRNA sponges but no function is known for the thousands of other circRNAs, indicating the existence of a widespread layer of previously unknown gene regulation.The present proposal aims to comprehensively determine the role and mode of actions of circRNAs in gene expression and RNA metabolism in the fly brain. We will do so by studying their biogenesis, transport, and mechanism of action, as well as by determining the roles of circRNAs in neuronal function and behaviour. Briefly, we will:  1) identify factors involved in the biogenesis, localization, and stabilization of circRNAs; 2) determine neuro-developmental, molecular, neural and behavioural phenotypes associated with down or up regulation of specific circRNAs; 3) study the molecular mechanisms of action of circRNAs: identify circRNAs that work as miRNA sponges and determine whether circRNAs can encode proteins or act as signalling molecules and 4) perform mechanistic studies in order to determine cause-effect relationships between circRNA function and brain physiology and behaviour. The present proposal will reveal the key pathways by which circRNAs control gene expression and influence neuronal function and behaviour.  Therefore it will be one of the pioneer works in the study of this new and important area of research, which we predict will fundamentally transform the study of gene expression regulation in the brain


**Keywords:** circRNAs miRNAs Drosophila circadia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Doctoral Industrial School for Vaccine Design through Structural Mass Spectrometry' (VADEMA), addressing dissemination and exploitation.

assistant: **Impact**

Vaccines discovered from empirical approaches and consisting in killed, live-attenuated microorganisms or purified components have led to the successful control of many devastating diseases. Several novel technologies, such as recombinant DNA technology, glycoconjugation, reverse vaccinology have opened the possibility of designing vaccines previously considered impossible to make. Despite decades of efforts, vaccines have not yet been developed against several of the most life-threatening infections. Based on the observation that an efficacious immune response only require protective epitopes, structural vaccinology combined with human immunology are therefore rapidly emerging as a powerful alternative strategy for the rational design of vaccines bearing multiple protective epitopes and offering the opportunity of developing broadly effective immunity. The proposal is focused on the development of a Structural Mass Spectrometry platform and its application to compare conformation and dynamics of antigens in their native states (membrane) with their recombinant soluble forms (vaccines) and to get a better understanding of the humoral response raised against the two forms. The outcome of such studies will be to identify antigen portions accessible to the host immune system and those epitopes that can be recognized in the native form of the antigens to design efficient vaccines.Structural Mass Spectrometry is a very new science in Europe and the proposal represents the unique opportunity for 4 PhD students to be trained by an academic and an industrial group, leaders in respective parts of the field. The program will be complemented with a number of training courses. The students will receive a PhD degree in structural mass spectrometry applied to vaccinology. It represen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Direct Coherent Detection Optical Transceiver'.

assistant: **Objectives**

The global data traffic within data centers is rapidly increasing due to the widespread use of digital services, cloud computing, and data-intensive applications such as AI and ML based queries, resulting in substantial energy consumption. Current transceivers used in data centers face technological limitations as they rely on complex parallelization or expensive components, hindering their ability to support higher speeds energy efficiently. Phanofi ApS offers a transformative solution to the escalating global data traffic challenges. Our patented Fano Detector technology enables utilization of intensity, phase, and polarization of light for data decoding without the need for many expensive, complex and energy intensive components required for current solutions. In our EIC Transition project, we will develop our first fully integrated Phanofi chiplet, leading to a compact & pluggable Phanofi 800G transceiver prototype. With a focus on high-speed transceivers, we will tap into a market with substantial growth potential, driven by the need to upgrade data centers and accommodate the rising demand for high-speed internet traffic. Our solution will enhance Europe's technological sovereignty in critical semiconductor and photonics sectors, reducing dependence on non-EU suppliers and position Europe at the forefront communication technologies. By enabling faster, more efficient data transmission, we support the growth of AI, machine learning, and big data analytics.


**Keywords:** Transceivers, Data Centers, 800G, Photonics, Intensity Modulation Direct Detection (IMDD) transceivers,  Coherent Detection transceivers, Fano resonance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Use of MIN-102 for the treatment of children with cerebral ALD' (MIN4ALD).

assistant: **Innovation**

The objective of the MIN4ALD project is the development of a new pharmacological therapy to treat paediatric patients with cerebral ALD (cALD) - the most rapidly progressive and devastating phenotype of X-ALD (X-linked adrenoleukodystrophy).cALD is a rare, fatal genetic disorder that affects nerve cells in the brain. Symptoms of cALD usually occur in a boy’s early childhood, and are characterized by rapidly progressive loss of visual, auditory, motor and cognitive function, with death usually occurring after 2 to 4 years from disease onset.Currently, there is no pharmacological treatment available on the market. The only existing alternative for cALD patients is hematopoietic stem cell transplantation, yet the procedure itself is very aggressive and results are not always optimal. Minoryx has developed a candidate drug that has demonstrated in several studies an excellent potential to treat patients with X-ALD. MIN4ALD Phase 2 demonstration is key to bring this unique treatment to the market. The results obtained in the Feasibility Analysis carried out indicated that MIN4ALD could be a huge business opportunity within the orphan diseases market.The Global orphan diseases market is a niche market valued at US$ 121.6 billion in 2015. It is expected to grow to US$ 576.9 billion by 2022, with an average CAGR of 24.9% during the period 2015-2022. This is an impressive growth compared to the Global pharma market, which projects a 6.3% CAGR through 2022. Minoryx has raised an important funding amount for R&D development from leading investors and has the support of reference Key Opinion Leaders. Minoryx received Orphan Drug Designation from both EU and FDA and holds a patent application covering the use of MIN-102 for X-ALD and other diseases affecting the central nervous syst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Emergence of Language in Social Interaction', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

During spontaneous sign language genesis, signers naturally come to integrate gestural material into their grammars. Researchers have been able to track this process in two famous cases: Nicaragua and Israel’s Negev desert. This project addresses a third case: Kata Kolok (KK) arose six generations ago due to high incidences of deafness in a Balinese village. ELISA determines what the earliest stages of this language looked like and what mechanism have shaped its emergence.Theories of sign language emergence have been based on comparisons of emergent signing varieties from geographically distinct areas and thus potentially very different gesture cultures. ELISA focuses on signing varieties within the context of Bali to enable direct comparison between the various stages of language emergence. Three potentially-interacting hypotheses are considered: gestural origins (the contribution of the spontaneous gestures used by speakers), time-depth (intergenerational transmission), and social interaction (community structure & quality of conversations).This is achieved byi) reconstructing the setting in which KK emerged by investigating the social interactions of homesigners and intergenerational homesign systems within the wider region;(ii) documenting the communicative structures of these homesigners as they interact with their hearing communication partners, and by comparing these systematically to generations III-V of KK; (iii) growing sign languages in the lab by asking hearing Balinese participants to describe events using silent gesture under various experimental conditions to test each of the hypotheses.Through this comparative approach, ELISA brings together the fields of sign language emergence and cultural evolution and is effectively able to chart the birth and develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A Collective Research Impact Framework and multi-variate models to foster the true engagement of actors and stakeholders in Health Research and Innovation' (MULTI-ACT).

assistant: **Innovation**

Conventional accountability metrics to measure the impact of  health R&I  process normally are not able to represent the claims of different actors. The development of a new integrated collective research impact  framework will be instrumental in enabling Return Of Investment (ROI) by each involved stakeholder in a view of collective sustainability. Economic and financial dimension (efficiency) has to be integrated with measures of mission success (efficacy), while being accountable to all the stakeholders who are directly or indirectly affected by an organization activity. Starting from the Integrated Accountability Model (IAM) in its different dimensions (mission, economic and social), new and appropriate metrics to evaluate impact of health research will be developed in a multistakeholder participatory approach. The IAM model will be expanded and fine-tuned in a new Collective Research Impact Framework (CRIF) to be applied to Multi-Stakeholder Research Initiatives in the domain of BRAIN diseases. The CRIF will be based on key requirements that will be jointly developed by different actors (i.e. research organizations, industry, civil society organizations, patients organizations, policy makers, governmental institutions): 1)the science of patient input; 2)common classification system to uniformly identify types of health R&I; 3)new metrics to measure the impact of R&I on patients and society; 4)strategic research global agenda and funding models; 5)committed partnership among health R&I stakeholders to create and oversee cooperative ventures; 6)mechanism to determine the nature of health R&I funding on a national level. MULTI-ACT proposal is led by patient organizations that act as mediators between science and patients/society. Addressed Responsible Research and Inn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of Multifunctional Zeolites for the Amelioration of Biomass Catalysis by Measuring and Understanding Synergistic Effects of Catalytic Active Sites', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Custom manufacturing of fine chemicals such as fuels, additives and plasticizers is a vital part of modern industrial chemistry. Increasing demand for the production of such chemicals necessitates the development of sustainable approaches. Biomass valorization is a potential solution to this problem; however, several challenges must be overcome to efficiently transform highly cross-linked biopolymers into desired chemicals. Notably, biocatalysts and heterogeneous catalysts offer promising efficiency for converting biomass-derived products in to small molecules. For such approaches to be successful, in particular when using heterogeneous catalysts, it is crucial to understand the local compositions, structures and synergistic effects between catalytic active sites on surfaces. Neglecting such factors during the biomass catalysis process is troublesome leading to reduced yields and undesired products. Here propose to develop a novel approach by combining zeolite post-synthesis modification with in situ and ex situ NMR spectroscopy techniques to gain a new molecular-level insight into zeolite-based biomass catalysis. We will accomplish this by modifying zeolites surfaces (via incorporating Zr, Sn, Zn and La heteroatoms into ZSM-5, USY and beta zeolite frameworks) using hydrothermal and chemical methods. The catalytic activity of zeolites will be tested for cascade conversions of sugar carbohydrates, lignin-derivatives and triglyceride-based compounds into valuable chemicals. The zeolite surfaces will be thoroughly characterized using electron microscopy, X-ray diffraction, BET isotherm measurements, 1D and 2D solid-state NMR techniques. This project is expected to create a significant leap forward in fundamental understanding and development of heterogeneous catalysts for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'RELIABLE, RECONFIGURABLE DC DISTRIBUTION NETWORKS'.

assistant: **Innovation**

This research will employ a new concept called virtual conductor that has been introduced by the Fellow through his PhD research. The overriding objective of the project is to investigate virtual conductors as the Direct Current (DC) equivalent of Soft Normally Open Points (SNOP), using them for improving the reliability of DC electricity distribution networks through DC network reconfiguration. Many consumer electronic devices need direct current (DC) input. All these DC devices require conversion of the supplied AC power into DC, and that conversion typically uses inefficient rectifiers. While the concept of using DC power distribution to interface distributed energy sources and loads to the power grid seems appealing at first, several issues must be addressed before this can be implemented fully. Intelligent control methods are investigated worldwide, to manage Distributed Energy Resource (DER) dispatch. Intelligent control can be extended to help improve operational security and reliability of electricity networks by utilising flexible resources. This research will focus on:1. Quantifying the benefits of a reconfigurable DC network with virtual conductors.2. Measuring the impact of introducing a reconfigurable DC network on electricity supply reliability, through the changes in specific reliability indices.3. Extending existing intelligent control code available by the supervisor, to design an intelligent control system which regulates the virtual conductors and implements their reconfiguration capabilities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A focus on degradation of ribosomal RNAs by the TRAMP/exosome RNA surveillance machinery' under Sixth Framework.

assistant: **Concept**

Nuclear surveillance and degradation of aberrant RNA requires the TRAMP complex, which promotes exosome-mediated degradation in the nucleus by adding poly (A) tails to aberrant RNAs. Interestingly, a mutant yeast strain defective in nuclear export of 60S preribosomes (sda1-2) accumulates ribosomal proteins, the TRAMP complex and the nuclear exosome in a punctate nucleolar structure, suggesting that preribosomes are degraded here.To address if in this structure is a general site for TRAMP-exosome mediated degradation of polyadenylated non-coding RNAs, I will use several fluorescence microscopy detection techniques to determine if other known degradation enzymes and non-coding RNAs targeted for degradation accumulate in this focus. Pre-mRNA surveillance by the nuclear exosome involves interactions with chromatin, transcription elongation factors, pre-mRNA processing factors and export factors and likely occurs co-transcriptionally. To determine if a similar surveillance mechanism exists for pre-rRNA processing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Network of Excellence in Model Based Systems and Qualitative Reasoning' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

This network of excellence proposes to advance understanding of, and success in applying, model based systems and qualitative reasoning technologies (MBS/QR). It will position and promote these technologies as uniquely able to help solve complex problems in European business, industry and socio-economic contexts. It intends to ensure their success for competitive European advantage in a range of industry sectors. MONET1 has created the infrastructure and gathered and organized the main players. Now MONET2 will build on and extend these achievements over the next three years.Objectives:1. Demonstrate that the application of MBS/QR methods can enhance the capacity of European industry to innovate and compete effectively;2. Transfer MBS/QR methods into industry and public sectors on a targeted basis;3. Demonstrate that success in applying MBS/QR technologies in one sector is transferable to others.Work description:The main focus of the work will be a number of task groups, each assigned to an industrial or public activity sector. Each task group will comprise 6-8 nodes and will be supported by an allocated budget. The groups will have objectives of investigating, assessing and formulating ways to establish, consolidate and extend use of MBS/QR methods in the respective sector, identifying and overcoming obstacles to wider use of these methods, promoting successes as encouragement for wider use, within and across sectors.For strategic reasons connected with this last point, the task group assigned to the automotive sector will be given special emphasis. This is because it is felt to be closest to securing those evident successes which will encourage take up within and across sectors. Supporting the task groups will be a co-ordinating node and a steering/executive group. The