RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Future of ALCL: Novel Therapies, Origins, Bio-Markers and Mechanism of resistance' (FANTOM) under Horizon Europe.

assistant: **Objectives**

The FANTOM Doctoral Network (DN) composed of 7 beneficiaries and 12 associated partners in 5 EU countries, recruiting 10 researchers and will be embedded into an established international research programme: The European Research Initiative on Anaplastic Lymphoma Kinase (ALK)-related malignancies (ERIA) as well as a clinical network: The European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL). FANTOM will cosset and nurture the recruited researchers to become confident, competent, independent and well-connected European scientists with excellent career perspectives welcomed into these established networks. This will be achieved through a training programme conducted through research and complemented by a balanced programme of transferable skills designed with key input from both academic and industrial collaborators. The training of each fellow will be guided by an individual career development plan and supervised by a PhD committee with clearly allocated academic and industrial supervisors. The primary goal of the network is to train the recruited fellows by participation in an internationally competitive research programme and integrating them into the aforementioned networks. The research programme will address the clinical problems posed by Anaplastic Large Cell Lymphoma (ALCL) typified by aberrant ALK expression. Applying innovative model systems and multi-omics technologies, some performed to a single cell level, the biology of ALCL including the roles of the immune system and tumour stroma will be uncovered. These data will be applied to the development of (non-invasive) biomarkers and novel therapeutic approaches that will culminate in the design of clinical trials to address the issues of chemotherapy toxicity, over-treatment and drug resistance. The re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Role of prenatal stress-induced fetal neuro-immune rewiring in susceptibility to develop pediatric eczema' (PRENATALL) under Horizon Europe.

assistant: **Objectives**

The prenatal period is a critical timeframe during which all the physiological systems of the body, including immune and sensory systems, develop their specific functions and adapt to possible incoming cues. Atopic dermatitis, also known as eczema, is the most common skin manifestation in infants and toddlers from 3 months to 2 years of age, with a very early onset during the first years of life. While genetic and immune factors play an important role, recent epidemiological studies have listed prenatal stress as an important risk factor of allergic disorders, and associated prolonged exposure to high emotional strain during pregnancy to an increase in the offspring susceptibility to develop eczema. The proposed project aims to seek external factors that might influence the development of eczema in infants through the lenses of neuro-immunology. We wish to use sophisticated mouse models, single cell transcriptomics and whole-tissue imaging approaches to evaluate how a relevant model of non-infectious prenatal stress can predispose offspring to develop eczematous lesions that resemble pediatric atopic dermatitis. We will then explore if the observed phenotype could be driven by in utero dysregulations of myeloid cells (in particular mast cells) and peripheral sensory neurons development and subsequent formation of abnormal skin neuro-immune units in offspring. To accomplish these goals, we have proposed herein a body of work that is solidly based on preliminary data, with four Aims that will test innovative hypotheses by using informative transcriptomic approaches, as well as a new multiplexed imaging system that we recently developed. This work will thus address significant gaps in our knowledge about how prenatal adverse events could set the stage toward the developmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Metabolic optimisation of intra-tumoral T cell motility' (MOTM) targeting Horizon Europe.

assistant: **Abstract**

Background.The tumor microenvironment markedly limits intra-tumoral T cell motility and the contact with tumor cells. Such a defective intra-tumoral motility of T cells is one of the main reasons explaining why current treatments based on reinvigoration/infusion of T cells to fight human solid cancers are unsuccessful. Metabolic reactions support T cell migration. Although T cell metabolism is severely de-regulated within different tumor areas, how this specifically affects intra-tumoral T cell motility is unknown. This aspect is important, since the metabolism of tumor-infiltrating T cells could be in principle easily modulated, opening a window of opportunity to improve current immunotherapy approaches against solid cancers, whose ineffectiveness is often associated with a poor intra-tumoral T cell motility.Objectives.I want to understand (i) which are the metabolic determinants of T cell motility, (ii) how the metabolic alterations within the TME affect T cell motility, and (iii) how to manipulate the metabolism of T cells and CAR T cells to improve their intra-tumoral motility and anti-cancer response.Main Methodologies.Viable tissue slices from human and murine tumors will be used to measure intra-tumoral T cell motility (real-time imaging microscopy) and metabolism (multiparameter imaging approaches, spatial gene expression, histo-cytometry) and to assess the consequences of the manipulation of the metabolic milieu on T cell distribution and motility. Also, CAR T cells will be engineered with new metabolism modules to improve their infiltration into solid tumor.Expected Results.The findings of this project will provide new insights into (i) how to improve the metabolic regimen of human solid cancer patients to increase T cell infiltration into tumor islets, and (i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Bioarcheology of the Late Mesolithic, the last HUnter-Gatherers of Europe'.

assistant: **Objectives**

Climate and socio-cultural changes are major ongoing concerns in our modern societies, their impacts on past populations are also central to understand the evolution of the human species, its resilience, and its capacity to adapt to new environments. 8200 years ago, the Mesolithic populations (hunter-gatherers) from Portugal faced a climatic event that profoundly changed their environment in a similar way to what is expected to happen in the next decades. In addition to these challenges, they were also confronted with the arrival of migrating Neolithic populations introducing farming, plant and animal domestication, and sedentism, gradually leading to the disappearance of the hunter-gatherer nomadic way of life.MUGE project aims to unveil the life story of the last hunter-gatherers from the Tagus valley (Muge village) in Portugal and to understand whether the environmental, and socio-cultural changes during the Late Mesolithic (ca. 8200-7100 cal B.P.) impacted the composition and health of these past populations. Discovered 150 years ago and representing the largest European anthropological collection for the Mesolithic (more than 250 individuals), humans from Muge are still poorly studied from a biological perspective because of the state of preservation of the skeletons. Cutting-edge imaging techniques will allow us to correct the taphonomic alterations and go into great detail in the analysis of skeletal remains, providing crucial information about the biological profile of the individuals (age-at-death, sex, etc.), the structure of the populations, and their health status.With more than 1000 years of occupation, Muge furnishes an ideal skeletal sample for exploring changes in health status through time and between sexes, adults, and non-adults but also between sites
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Control of rinderpest (rp) and peste des petits ruminants (ppr) infections: development of oral vaccine, role of wildlife in the maintenance of these diseases' (1998-2002).

assistant: **Concept**

PROPOSAL for INCO-DEV (call identifier: ICFP599A4PROl):PROPOSAL ABSTRACT (maximum 1000 characters)Because of their high mortality and high morbidity rates, rudderpost (RP) and paste des petites ruminants (PPR) are dreaded animal diseases which are drawing back the animal production in many developing countries (Africa, Asia). They affect both domestic and wild ruminants. They belong to the list A of the Office International des Epizooties, list where highly contagious animal diseases with high economic importance are grouped. Tran boundary diseases, they are among the 6 animal diseases targeted in the EMPRESS programme. This is an FAO priority programme which aims to ensure effective prevention and progressive control of plant and animal pest's diseases to ensure world food security. n many countries, programmes are launched to control both RP and PPR by vaccination with unemotional funds support, mainly from EU. The present proposal aims to develop RP/PPR heal stable oral vaccines better adapted for mass vaccination in hot cleanable developing countries. Such vaccines, in opposite to the current ones, might be used to control RP and PPR in wildlife in game parks. Thus the expected results from this proposal will be a support of some EU developing programmes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Joint Doctorate in Biology and Technology of Reproductive Health' (REP-BIOTECH), addressing dissemination and exploitation.

assistant: **Impact**

The main objective of the European Doctorate in Biology and Technology of the Reproductive Health (REP-BIOTECH) is to build a research, training and academic programme in the interdisciplinary domain of reproductive health and fertility. Basic knowledge of mechanisms involved in mammalian fertilization and embryo development provides useful strategies to improve food quality (by implementation of efficient and secure animal reproductive technologies), human health (by contributing to the control of reproductive diseases and epidemiologic factors) and human and animal fertility (by identifying target molecules for successful conception or contraception).REP-BIOTECH is a PhD programme with the aim of training a new generation of creative, entrepreneurial and innovative Early-Stage Researchers (ESRs). ESRs must carry out independent research on a specific topic to be awarded a European Joint Degree from 5 European Universities (Beneficiaries). The PhD project will be jointly supervised within a joint governance structure in which the beneficiaries as well as the partner organisations will be actively involved. The Doctorate programme will expose ESRs to different sectors and they will acquire a comprehensive set of transferable skills working in the specific research area relating to their doctoral thesis.The consortium has a proven track record in their area and they have a history of fruitful scientific collaboration. Moreover, giving the diversity amongst the participating institutions, the ESRs will be able to face current and future challenges in order to convert knowledge and ideas into products and services for economic and social benefit. The strength of the partnership lies in being a multidisciplinary group (animal and human fertility, reproductive health and rep
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Assessing the technical and business feasibility of Callose Enriched Plant Biomass as a solution for improving Biorefinery Industry processes and profit margins' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

BioBiorefineries are facing a positive economic outlook due to the ever-growing concerns for climate change, which is triggering demand towards carbon neutral materials and energy derived from renewable sources. However, the growth of the industry is hampered by their low profit margins and additional investments and innovations are needed to improve process efficiency.The key problem in migrating towards green production is the biomass recalcitrance, which is known to be a major bottleneck in the lignocellulosic biomass conversion process. The initial steps common to several biorefinery process pipelines, the extraction and sugar conversion process (saccharification), can account to as much as 40-45% of the process costs. Therefore, biorefineries can achieve extensive economic impact by addressing this part of their process through a simple business development effort.We recently made a breakthrough and obtained a biomass less recalcitrant to bioconversion into fermentable sugars. Results show that introduction of only 5% Callose in genetically modified poplars led to 90% more fermentable sugars released during saccharification experiments without any growth penalty, a frequent drawback for such innovations. In practice, this proposes added value to biorefineries through decreased raw material intake, improved throughput and improved yield. For instance, bioethanol production could expect a linear throughput increase (in the 50-90% range) with the same material intake. Moreover, the more manageable pretreatment process will also experience improved energy efficiency.In the PoC we will carry out technical proof-of-concept and commercialisation planning activities to improve the maturity, and bringing our patented innovation closer to the markets with applications rangin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Interferometric observations of planetary systems' in the context of a Sixth Framework call.

assistant: **Objectives**

The aim of this project is to detect extra-solar planets around other stars by infrared interferometry using the ESO VLTI. Extra-solar planets orbiting very closly around their host star can be detected directly only with this new technique. Only such a direct (astrometric) detection can give their true mass, which is otherwise unknown. The AIU host institute is well capable of all other planet detection techniques (rad vel, transit, astrometry, direct imaging), but needs new expertise for interferometry. The goal is to detect close planets and to detect fainter, i.e. lower-mass Earth-like planets around other stars. This project involves basic science institutes (astronomy), applied RandD institutions (optics), and photonics companies in the less-favoured region of Thuringia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Research and education centre for urban socio-economic development'.

assistant: **Innovation**

The Department of Economic Geography at the University of Gdansk achieved the leading role among the national and NAS urban studies centres, introducing the social approach into the Polish urban studies. The Department has developed intense contacts with European urban research centers. The created Research and Education Centre for Urban Socio-Economic Development (RECOURSE) will foster those ties and better integrate the research within ERA. The proposed package of measures as networking with European institutions, twinning with a fellow centre in Europe, joint workshops, conference, visiting fellows, training for PhD and post-doctoral researches will enhance the research and education capacity of the Centre. The RECOURSE will play a role of the bridge between EU and other NAS institutions in transferring, promoting and disseminating the results of co-operation in the area of sustainable urban development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Natural Product-Inspired Therapies for Leishmaniasis and Chagas Disease'.

assistant: **Innovation**

The development of new therapies for leishmaniases (which affeThe development of new therapies for visceral leishmaniasis (affects ~12 million people worldwide) and Chagas disease (~6-7 million people worldwide) is critically dependent on the identification of novel pharmacophores with new modes of action. Current treatments suffer from severe side effects, high cost, patient compliance issues, and emerging resistance; as such, new therapeutic leads are urgently required. Despite significant investment, limited progress has been made with research into new 'synthetic' drugs: no candidates are in clinical trials (although two compounds have recently progressed to preclinical evaluation for VL). In contrast, research into natural product-derived drugs has been largely ignored, despite their track record as frontline treatments for VL (amphotericin B) and the most prominent parasitic disease, malaria (artemisinin). In this project, we challenge this dogma through the exploration of a series of structurally-related alkaloid natural product families, where highly promising antiparasitic bioactivity has been observed in the few examples studied. The selection of these families is additionally based on their accessibility through concise, modular and convergent synthetic strategies, which facilitate modification. We couple this central focus of synthetic chemistry with collaborations to evaluate bioactivity (with expert parasitologist Prof Andre Tempone), and identify pharmacokinetic/dynamic limitations (with expert pharmacologist Prof Kevin Read), thereby informing analogue refinement and synthesis. This multidisciplinary approach will greatly enhance the impact of the synthetic chemistry work by providing 'real-time' feedback into compound design, enhancing project efficienc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Physics-based Remote Touch' to be submitted under Horizon Europe.

assistant: **Abstract**

Humans rely on their sense of touch to achieve fine manipulation tasks and interact with their surroundings. However, feeling the tactile properties of a remote environment remains a challenge for two main reasons: first, current robotic systems are rarely equipped with tactile sensing and second, only forces are fed back to the users. In this project, the final goal is to create a bilateral tactile telemanipulation system, bridging the gap for touch over a distance. To cope with the large bandwidth required for this tactile interaction, I propose a new encoding of the tactile information, inspired by human touch. First, I will  acquire a large database of robotic mechanical interactions in order to extract primitives of spatio-temporal deformation. Second, this dictionary will allow me to distill tactile features from any interaction and render tactile properties to a remote user.The robotic decoding part will be carried out under the supervision of Prof. Adelson in the Massachusetts Institute of Technology, using the GelSight tactile sensor. In the return phase, I will integrate humans in-the-loop by designing a novel haptic device and studying the effect of applied skin deformation on the perception of tactile properties. This integration will be done under the supervision of Dr. Wiertlewski from Delft University of Technology. This interdisciplinary project requires skills in biomechanics, perception, robotics and control as well as modeling and machine learning, which will be part of the applicant training.If granted, this project will for the first time encode the tactile information in a dictionary of primitives, essential for sensing, compression, and reproduction of rich tactile stimuli. In addition, the remote touch platform will have applications in a wide ra