RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'VR Surgical Simulation for training: simulator design, optimisation and assessment' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The better surgeons are trained, the safer surgery procedures will be. Virtual reality (VR) surgical simulators offer new possibilities for surgeon learning, training and assessment, but they are complex to design, requiring contributions from different disciplines, such as engineering, medicine and psychology. Unfortunately, it is difficult to achieve a proper interdisciplinary communication. Most projects in surgical simulation are strongly influenced by the engineering point of view, with weak contributions from the rest. This unbalance and the lack of industry support often lead to a premature end of the project. The fellowship aim at the Imperial Robotics and Imaging Research Group, in the Faculty of Medicine, is to evolve to a professional maturity and to reach a multidisciplinary view to improve the way simulators are applied to minimally invasive surgery (MIS). The training objectives are focused on enhancing my research skills and strengthening my interdisciplinary knowledge by acquiring medical complementary skills. This will allow to apply my previous background on computer science, VR and simulation techniques (see the commercial insightARTHROVR® simulator) to satisfy surgeons’ needs. The main research objectives are: 1. To develop education and training programs for surgeons based on learning theory, using the potential of virtual reality resources. 2. To research which algorithms and simulation techniques need to be improved in order to make surgical simulators a more valid tool; and to design VR surgical simulators adapted to the surgeons’ needs. 3. To perform surgical simulator assessment and to research on the evaluation of surgical competencies. A Personal Review and Development Plan in conjunction with Dr. F. Bello and the Staff Development Unit at th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'NUMERICAL SIMULATION OF SEDIMENT ENTRAINMENT'.

assistant: **Innovation**

Sediment transport is important for predicting the impact of human intervention on river and coastal systems. The numerical modelling of individual particles on the bed of a turbulent open channel is particularly difficult because it not only involves the correct modelling of the turbulence but also the movement of the particles themselves. This project is aimed at investigating the influence of turbulence on the entrainment and movement of coarse particles on the bed of an open channel. In order to do this it will be necessary to couple existing in-house discrete element and computational fluid dynamics codes. The final code will be able to correctly model the turbulence in the channel and around the particles. From a geomorphological point of view, the research will be a major contribution to the understanding of sediment dynamics by focusing on the movement of individual particles, turbulence around these discrete particles and the role of turbulent eddies in particle entrainment. It will lead to improved understanding of bed mobility in rivers with non-cohesive sediment. Simulations will be carried out to investigate the influence of turbulence on the entrainment of the particles. We shall look at factors that influence the stability of the particles, such as: drag and lift forces, degree of protrusion, blocking by particles upstream, effect of particles downstream on the points of rotation of a moving particle.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biotechnological Enhancement of Bee Products for Sustainable and Functional Foods in Well-Aging' to be submitted under Horizon Europe.

assistant: **Abstract**

The BEE-TECH initiative aims to revolutionize bee-derived products by developing next-generation functional ingredients and powdered superfood blends with high biological value and well-aging benefits. By leveraging cutting-edge processing technologies and eco-friendly extractionThe objective of BEE-TECH initiative is to reinvent bee products, creating innovative functional ingredients and powdered superfood blend for further products applications with significant biological value and health well-aging advantages. To achieve this goal, bee products, including propolis, pollen, royal jelly, and bee bread from various BEE-TECH partners' geographical locations, will be gathered through partnerships with beekeepers. These samples will undergo thorough analysis to assess their composition, nutritional value, and health-related aspects. The collected samples will be utilized in their original forms and as extracts obtained through novel, environmentally friendly green techniques. These extracts, along with other samples, will be incorporated into the development of new functional powdered superfood blends as well as other functional foods, broadening the application of these high-health-value products. The resulting functional formulations (concentrated source of nutrients, antioxidants, and phytochemicals) will be characterized and evaluated for nutritional content, sensory attributes, and their potential health effects, particularly in the context of well-aging properties. Simultaneously, innovative processing methods like cold plasma, PEF, and encapsulation will be implemented to enhance the biological value or bioavailability of the functional ingredients of bee products. Besides, fermentation as a traditional technique but a novel tool for the improvement of nutritional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Partnership for Numerical Acoustic Simulation of aero-engines'.

assistant: **Objectives**

The PARNAS project (1) focuses on an important industrial application (reduction of aircraft engine noise using optimized acoustic liners designed), (2) investigates fundamental mathematical aspects of the related simulation techniques (FEM, DGM, PUM), (3) builds upon three successful FP5 and FP6 research projects where some technological components have been developed and where the partners have learned to work together, (4) Organizes exchanges between five teams in four countries with extensive expertise and skills in the related domain as researchers, developers and users of the underlying technology. PARNAS aims at developing new techniques (PUM), further validating and enhancing recently introduced techniques (DGM) and deploying existing techniques in industry (FEM).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Origins and factors governing adaptation: Insights from experimental evolution and population genomic data' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

I propose a systematic study of the type of genetic variation enabling adaptation and factors that limit rates of adaptation in natural populations. New methods will be developed for analysing data from experimental evolution and population genomics. The methods will be applied to state of the art data from both fields. Adaptation is generated by natural selection sieving through heritable variation. Examples of adaptation are available from the fossil record and from extant populations. Genomic studies have supplied many instances of genomic regions exhibiting footprint of natural selection favouring new variants. Despite ample proof that adaptation happens, we know little about beneficial mutations– the raw stuff enabling adaptation. Is adaptation mediated by genetic variation pre-existing in the population, or by variation supplied de novo through mutations? We know even less about what factors limit rates of adaptation. Answers to these questions are crucial for Evolutionary Biology, but also for believable quantifications of the evolutionary potential of populations. Population genetic theory makes predictions and allows inference from the patterns of polymorphism within species and divergence between species. Yet models specifying the fitness effects of mutations are often missing. Fitness landscape models will be mobilized to fill this gap and develop methods for inferring the distribution of fitness effects and factors governing rates of adaptation. Insights into the processes underlying adaptation will thus be gained from experimental evolution and population genomics data. The applicability of insights gained from experimental evolution to comprehend adaptation in nature will be scrutinized. We will unite two very different approaches for studying adaptation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'On-site biological sensing for aquatic pollutants and biohazards' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

AquaBioSens aims to drive the decentralisation of tools for the measurement of aquatic hazards and pollution. We will produce and demonstrate new handheld devices to measure contaminants of emerging concern, microbial biohazards and heavy metals. The aim is to make monitoring more efficient and widely accessible, supporting the EU Mission to “Restore our ocean and waters by 2030” Mission, and specifically the Destination “Clean Environment and Zero Pollution”, as well the Water Framework Directive and Marine Strategy Framework Directive. We will achieve this by developing novel analytics based on cutting-edge techniques: i) immunoassays to measure organic contaminants, ii) isothermal environmental RNA quantification for harmful microalgae and fecal coliform bacteria, and iii) two novel whole cell biosensors based on genetically modified diatom microalgae and fish gill epithelia for multiplexed heavy metals quantification and toxicity assessment.  These will be coupled with state-of-the art sensors such as acoustic biosensors, multichannel fluorimetry and organ-on-chip microfluidic devices. Low-cost fabrication strategies will ensure that the developed technologies are accessible to end-users, such as industry operators and government inspection agencies responsible for environmental monitoring. New digital real-time data feeds will enable seamless data flows from sensors to the web, including a dedicated live dashboard. The prototype devices will be demonstrated and validated in potentially polluted coastal and freshwater environments in the UK, Ireland and Greece, with the support of local government inspection agencies. Together with measures to disseminate results widely to the international community, stakeholders and citizen science groups, we will maximize exploit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Host immune activation optimised vaccinia virus vectors for vaccine development' (MVACTOR), addressing dissemination and exploitation.

assistant: **Impact**

The overall objective is to develop a new generation of potent viral vector vaccines with optimised host immune activating properties. Poxviruses engineered to express foreign genes are recognized as potent delivery systems for heterologous antigens. One of these vectors, the safety-tested modified vaccinia virus Ankara (MVA), a product of European research, serves world-wide as the vaccinia virus strain of choice for clinical investigations research experimental vaccination against AIDS, tuberculosis, or malaria. Recent work performed by our network consortium significantly increased our knowledge about versatile poxviral gene products exploited by these viruses to regulate virus-host interactions and to counteract innate and adaptive host immune responses. In this project application, vaccinia virus MVA serves as the basis to specifically inactivate viral gene functions that have immune inhibitory potential. We will use the research experience and the highly competitive bioengineering capabilities of the network partners to establish a unique technology platform for poxviral vector design in vaccine development. On the basis of important results from research performed under our previous contract EC QLK2-2002-01867 we will test combinations of genetic modifications targeting MVA gene products interfering with host cytokine and chemokine function or apoptosis-triggered danger signalling. In addition, we will design novel strategies for viral vector associated antigen presentation and adjuvant delivery. Comparative vaccination experiments in animal model systems for immunization against viral and parasitic will allow us to determine the relative enhancement of antigen-specific immune responses (T cells, antibodies) and to analyse the protective capacity of MVA vector va
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Overcoming Monocyte Complexity in Pulmonary Fibrosis Progression from Onset to End-Stage'.

assistant: **Objectives**

Progressive pulmonary fibrosis (PF) is a debilitating and incurable disease. Scaring of the lung leads to respiratory failure and 50% of patients die 3-5 years after diagnosis. Our understanding of the pathophysiology of PF is unfortunately limited to established and advanced stages when the extensive lung scaring is irreversible. OMEGA is designed to explore new mechanisms underlying PF progression, from early to advanced disease and propose therapies that timely target the disease, prior to becoming permanent. Two lines of evidence are at the core of OMEGA. First, I was among the first to show that circulating monocytes are strongly linked to PF pathology. Which subtypes are important and what roles they play in PF etiology, however, is still unknown. Second, interstitial lung abnormalities or ILA are the only detectable features characterizing earlier stages of PF and can be identified in people without clinical suspicion of disease. Studying ILA provides the unique opportunity to identify early targets that would prevent progression to PF. OMEGA will first provide a detailed phenotype definition of human monocyte subtypes from early to advanced PF. Second, it will probe mechanistically how and where the monocytes acquire a pathogenic phenotype as they journey from the bone marrow to the blood and differentiate in the fibrotic lung. I will use human and mouse material and state-of-the-art methodology to answer these questions. My current standing ensures direct and ample access to patient samples, clinical data, multi-disciplinary interactions, and a team of consultants/collaborators that will make possible identifying how monocytes and their progenitors are involved in the progression of PF, and what pathways we can target, as early as disease starts, and as early a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Glycogenomics and glycobiotechnology of mannosylated glycoconjugates' in the context of a Sixth Framework call.

assistant: **Objectives**

This Marie Curie Excellence Grant proposal by team Leader N. Callewert focuses on the application of a technology core for the isolation, analysis and bioengineering of mannosylated glycoconjugates. This technology core is now sufficiently advanced to explore its utility in tackling a number of long-standing biomedical and biotechnological challenges: vaccine design, genomic analysis of pathogen glycoconjugate biosynthesis pathways, and production of sufficient quantities of homogenously glycosylated proteins for structural analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Alternative agriculture for a sustainable rehabilitation of deteriorated volcanic soils in mexico and chile'.

assistant: **Innovation**

By means of on farm research with sustainable agriculture (with principles of organic farming and agro forestry) on eroded volcanic soils in Mexico and Chile, suitable cultivation practices will be identified to prevent erosion and to rehabilitate deteriorated soils. The effects of the different cultivation techniques and agro forestry on the sustainability of the soil fertility and soil structure will be monitored. Also the situation of the rural population, including the role of the women and young people in agriculture, will be evaluated. The results of the demonstration trials will be implemented and disseminated among the local producers, associations and governmental institutions. The evolution of the cultivation techniques used by the small holders and the changes in their living conditions will be followed up to investigate the sustainability/acceptance of the measures by the local rural population.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Photon Management for Solar Energy Harvesting with Hybrid Excitonics' (SOLARX).

assistant: **Innovation**

In nature, biological light harvesting complexes use antennas molecules to harvest photons, generate excitons and then funnel them to the reaction centre where their energy is used to drive photosynthesis. Inspired by this paradigm, SOLARX will explore new strategies for photon management in solar energy harvesting, based on the transfer and manipulation of excitons at hybrid interfaces. At the core of SOLARX is our development of a new femtosecond transient absorption imaging technique with sub-10fs time resolution and sub-diffraction limit spatial resolution. This opens completely new possibilities to explore excitonic physics at the nanoscale, directly visualising not just the motion of excitons but understanding how vibronic coupling and local structure affects their dynamics. Building on this platform we will deliver ground-breaking new insights into excitonic process in and at the interfaces between organic semiconductors, quantum dots, 2D monolayer semiconductors and lanthanide doped nanoparticles. We will elucidate the fundamental nanoscale dynamics of: (1) endothermic singlet fission, (2) the injection of triplet excitons into lanthanide doped nanoparticles and (3) the motion of excitons in 2D monolayer semiconductors and how these excitons can be funnelled over µm length scales to be transferred to quantum dots. We will then use these insights to develop proof of concept demonstrations of structures which harvest photons across the visible and NIR, efficiently converting high energy visible photons to two NIR photons and then concentrating these photons within structures with the potential to achieve concentration factors well above 100, thus concentrating light to drastically reduce the number of PV panels and hence dramatically reducing the cost of solar ene