RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'IMPROVING THE QUALITY OF EU WHEATS FOR USE IN THE FOOD INDUSTRY' to be submitted under Fourth Framework.

assistant: **Abstract**

The objectives of this project is to determine the molecular basis for the functional properties of wheat for breadmaking and other food uses, using a combination of biophysical, biochemical and molecular genetic approaches, including the production and analysis of transgenic wheat plants.Spectroscopic studies of whole HMW subunits and subunit peptides have provided a detailed understanding of the structures and properties of the whole subunits and their three structural domains:1. Spectroscopic analyses of purified subunits and repetitive peptides has led to a novel theory for gluten elasticity based on inter-chain hydrogen bonding;2. Comparisons of allelic pairs of HMW subunits associated with good and poor bread making performance have shown differences in their stability to unfolding and specific molecular interactions that may lead to impacts on gluten elasticity;3. A new series of near-isogenic lines which differ in their number and composition of HMW subunits has been produced in the cultivar Pegaso.Transgenic lines have been produced expressing wild type and mutant HMW subunits. Biochemical and functional studies of transgenic lines grown in replicate field trials have demonstrated that the expression of additional HMW subunits can lead to increased elasticity or to more dramatic changes in processing properties, the latter being associated with a high proportion of insoluble glutenin polymers.The underpinning knowledge provided will facilitate the development of new types of wheat with optimised raw material quality using genetic engineering. Wheat flour consists of about 80 % starch, 10 % protein with small amounts of other components such as lipids and pentosans. Although all of these may contribute to the functional properties, the proteins appear to be part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Intermodal PortalTask 2.3.2/2 innovative Waterborne Transport Concepts' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The IP Project will improve the integration of ports into intermodal transport chains by harmonising administrational procedures and offering a set of information and communication (ICT) tools and services for easing the mandatory data supply as well as the data delivery to other partners in the chain.This will be done by integrating results of previously successful RTD projects and industrial strength solutions into a large scale demonstration covering 20 of the major seaports all over Europe (from Finland to Greece).IP is a combined RTD/Demonstration project for the Task 2.3.2/2 Innovative Waterborne Transport Concepts" of the 1st Call for the 5th Framework Programme, Thematic Programme "Competitive and Sustainable Growth", Key Action "Sustainable Mobility and Intermodality"."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'AXVIRIUM BIOACTIVE TECNOLOGY_ The first medical device able to eliminate the fluids biological hazard'.

assistant: **Concept**

The aim of the project is to validate the technical and economic feasibility of AXVIRIUM BIOACTIVE TECNOLOGY (ABT) an innovative biomedical device, based on the Adantium® Plus and Axivirium BIOACTIVE® molecules, enable to cut biological risks, improve efficiency and reduce cost of health care biomedical fluids disposal. Medical waste is posing a growing problem worldwide resulting in nearly 7000 tons every day of infectious /hazardous medical waste and 10 billion euro annually in disposal cost across the European health care industry. According to the World Health Organisation (WHO), incorrect and improper management of healthcare biological fluids can have direct impacts on the community, individuals working in health care facilities, and the natural environment. It estimated that at world level accidents caused by not proper biological risks management accounted for 66,000 cases of infection with the hepatitis B virus, 16,000 cases of infection with hepatitis C virus and 200 to 5,000 cases of HIV infection amongst the personnel of health-care facilities. Compared to competitors ABT is the unique solution able to reach 100% degradation of RNases almost in real time and completely sterilize biological fluids. This imply saving operational cost up to 20%, decreasing occupational diseases by 39% and reducing cross- nosocomial infection by 14%. In 2018, the valuation of the global fluid management market was EUR 10 billion and is anticipated to reach EUR 18 billion by 2022, at a positive CAGR of 4.8% in the next three years. The estimated market potential for ABT is about 21 million euro and we estimate to hire 23 high skilled employees. The feasibility study comprises an investigation of market structures, segments and barriers, a customer survey and product validation, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Improved antioxidant content for food applications' (PROFOOD) under Fifth Framework.

assistant: **Objectives**

Flavonoids and phenol acids are widely distributed in higher plants and form part of the human diet. Recent interest in these substances has strongly been stimulated by the potential health benefits arising from the antioxidant activity of these polyphenolic compounds. Although the protective effect of flavonoids against cardiovascular disease and some forms of cancer is widely accepted, little is known about the different pharmacokinetic properties of individual groups of flavonoids. The aim of the proposal is to develop strategies to create tomato plants with elevated contents of flavonoids, to evaluate the biological properties of individual members, and to transfer the knowledge to additional crops including cereals. To achieve this goal, an interdisciplinary team has been put together with outstanding expertise in plant molecular physiology, genetics, biochemistry, nutritional and analytical biology, complemented by a SME as an active participant and responsible for the exploitation of the results obtained.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Structured Training and Advanced Research in Marine Active Structures' (STARMAS) targeting Horizon 2020.

assistant: **Abstract**

In the last 25 years the total amount of marine trade has nearly doubled. In the same period the container trade has undergone a tenfold increase, making the container fleet the fastest growing fleet at present. With 80% of total EU trade being transported by sea, the maritime transport is of the greatest importance to the EU. The increasing demand in container transportation is met by use of more containerships. Such ships with large bow and stern flares and fine underwater hull are severely hit by an effect known as parametric rolling. Accidents including container loss and vessel structural damage are reported from all around the world. Capsizing could be regarded as a rare event, but the consequences of such event are fatal (loss of the ship and the crew). Agencies, classification societies and the public are showing more and more interests in increasing the safety of large container ships. STARMAS is a highly interdisciplinary integrated research and training programme focused on the application of novel active control methods to increase safety, energy efficiency and quality of life at sea of the 21st century maritime transport. The problem of ship roll on rough seas will be tackled using novel active roll control methodologies. Bi-directional transfer of knowledge and cross-fertilisation between traditionally detached engineering disciplines will be unlocked, utilising a unique research approach to enduring engineering problems related to sea keeping, survival rate, and energy efficiency of marine vessels. The programme will boost the career prospects, increase employability and widen the set of skills of the experienced researcher. The training and research will predominately take place within the academic sector, at the Faculty of Mechanical Engineering and Nav
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Site-selective chemical pyrophosphorylation of proteins using tag-and-modify approach.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Post-translational modifications (PTMs) occur on nearly all proteins in eukaryotic cells to diversify their proteome. These chemical modifications of various amino acids side chains can influence protein association with other biomolecules, or control cellular signal transduction networks and the activity of enzymes. Reversible protein phosphorylation is one of the most common PTMs. It is considered as a signalling mechanism involved in almost all cellular processes. On the other hand, protein pyrophosphorylation mediated by the inositol pyrophosphate messengers was discovered recently and its function on proteins is completely unknown. Up to date, direct evidence of its role in vivo is still missing. Exploring the potential role of protein pyrophosphorylation is limited by lack of a robust method of installing pyrophosphate residue in desired position of full length proteins. Here we propose chemical site-specific pyrophosphorylation of proteins using “tag-and-modify” approach. It relies on expression of protein bearing cysteine in the position of interest. The cysteine is then chemically converted to dehydroalanine (“tag”), which reacts with various sulphur or carbon nucleophiles under mild conditions to introduce pyrophosphate PTM mimics (“modify”). The method allows preparation of not only pyrophosphorylated proteins, but also their phosphatase resistant analogues. These will be invaluable for mechanistic studies of pyrophosphorylation reversibility and its biological role. As a proof of concept, well defined chemically pyrophosphorylated transcriptional factor GCR1 will be prepared by proposed strategy. The influence of GCR1 pyrophosphorylation on interaction with GCR2 will be explored, since this is assumed to control transcription of glycolytic genes in yeast. Ou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'PJ.19 W2 Content Integration, Performance Management and Business Case Development' to be submitted under Horizon 2020.

assistant: **Abstract**

PJ19 W2 CI  is a transversal activity of the SESAR 2020 Programme in continuation of the SESAR Wave 1 PJ19 CI Content Integration project.It aims to integrate the SESAR Solutions into the integrated European ATM System in order to achieve the objectives set by the ATM Master Plan (MP). This integrated European ATM System provides the overall European ATM concept, the high-level architecture options, the services, the supporting solutions, and the performance achievements associated with them. As such, PJ.19 W2 does not create any specific ATM concept or solution but produces a set of deliverables which consolidate the SESAR 2020 Programme outcomes and provides yearly integrated reference material – the SESAR 2020 Architecture release (EATMA version) . This is done in close collaboration and coordination with all SESAR 2020 Solutions and the SJU through continuous, rolling and iterative content integration.PJ19-W2 allows the assessment of the overall performance of the SESAR Solutions compared with the performance improvements expected for the European ATM.Whilst the decisions are made by SJU management and SESAR governance, PJ.19 W2 activities support and guide the processes (e.g. safety, security assessment, human performance, performance assessment, cost benefit analysis (CBA), architecture, requirements) to bring the SESAR Solutions together and assess their maturity (completeness, consistency and coherency) from a holistic perspective represented in the SESAR 2020 Concept of Operations. The PJ.19 W2 activities provide major inputs for the ATM MP production (ATM architecture information (e.g. data set), performance and CBA consolidation, business case production), which are further consolidated at the time of the ATM MP update campaign by the PJ.20 W2 ‘Master Plannin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'RIS for South East Region of Bulgaria'.

assistant: **Concept**

The proposed project represents a first step of a collective effort to support innovation in the South East Region of Bulgaria that will lead to the successful integration of the Region into the European Research area.The aim of this effort is to unite all the regional bodies that promote applied research, co-operation between research and industry, technology transfer, human technology skills and entrepreneurial capabilities for the renewal of products, production processes and effective competition o n global markets.This interest for innovation and technology transfer is based on the importance of innovation to maintain employment, competitiveness, and improve the living standards of a region. SerBul project explores the way innovation processes will be promoted through companies, institutions and local governments on the regional level.Public and private institutions as well as big enterprises, local authorities and local support systems of research, training and financing of new innovative activities have a key role to play in this field. SerBul project aims at creating the proper conditions for individual and group participation in creation of new ideas and projects; influencing the dynamics of innovation creation and distribution, particularly in the case of companies that carry out production and processing of processes using advanced technology.Creating the right innovation climate is of great importance for small companies. To survive, they have to cooperate with other companies and institutions. A co-operation by means of networking or clustering allows for overcoming barriers and helps smaller companies to become more competitive.The work during the development of the RIS will be focused on on-line transfer of know-how from the foreign partners to the South
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Correlation of nano-scale structure with magnetic interface properties of ultra-thin metal films' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content The field of surface magnetism has expanded rapidly in the last decade. Novel magnetic properties Have been theoretically predicted and experimentally verified for ultra-thin films, surfaces and interfaces. It has been shown that these magnetic properties are critically dependent on surface structure. The aim of this project is to combine surface analysis with magnetic measurement techniques to investigate the interdependence of ultra-thin film structure/morphology and magnetic behaviour. Ultra-thin metal films will be grown and characterised in ultra-high vacuum. Nano-scale chemical-selective imaging will be developed to investigate interface effects such as substrate segregation. The magnetic properties of the films will also be studied in-situ using Magneto-Optic Kerr Effect (MOKE) and Kerr microscopy. Films will be capped for ex-situ non-linear MOKE and magnetisation measurements. The influence of capping layers on film structure/morphology and magnetic properties will be investigated in-situ. Training content (objective, benefit and expected impact) The training involved in the project will allow the candidate to develop and complement his experience in surface analysis methods with a range of thin film magnetic measurement and surface analysis techniques. These will include chemical-selective imaging, linear and non-linear MOKE, magnetic imaging and thin film magnetic measurements. The candidate will gain valuable insight into the interplay between surface magnetism and structure. Links with industry / industrial relevance (22) The host group has links with several companies actively involved in surface magnetism research involving local-probe techniques. Among these are IBM, Siemens, Philips and Omicron.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Adaptive optics operation for lasers' (ADAPTOOL).

assistant: **Concept**

Description:The ADAPTOOL programme consists in the development and implementation of active control of the spatial phase of Europe's high power laser facilities.This will improve access by:1. Improving the beam quality close to the diffraction limit;2. Improving the shot rate of large laser systems;3. Relaxing the tolerances and cost of optical components.The fundamental principle of an Adaptive-Optic system is that of a process loop in which a wave front detector feeds correction signals to an optical actuator. This programme sets out to identify the most cost effective and technically appropriate solutions to the adaptive beam correction requirement for Europe's large-scale laser installations. We intend to exploit the rapidly advancing technology of commercial liquid crystal displays and we will pursue a parallel low risk development of existing deformable mirror technology.Results:In the first 12 months of the project, partners have successfully designed, bought, built and implemented:- radial shear interferometers and Shack Hartman sensors (wave front detection and measurements);- deformable mirrors (commercially available or home made mirrors);- laser beam propagation modelling with detection/correction closed loop;- advanced liquid crystal spatial light modulator (designed for large aperture and high damage threshold purposes).Project Manager:Bruno Le Garrec, Centre d'Etudes Scientifiques et Techniques d'Aquitaine (CESTA) /Département des Lasers de Puissance, Bâtiment 214, Le Barp 33114, B.P. 2, FranceTel: +33-1-45956843Fax: +33-1-45956505E-Mail: blegarrec@bordeaux.cea.fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'STIMULATION OF ENERGY EXPENDITURE AND BROWN ADIPOSE TISSUE IN HUMANS' to be submitted under Seventh Framework.

assistant: **Abstract**

Obesity is the result of a mismatch between energy intake and energy expenditure. Part if excess calories will end up as fatty acids. The excess lipid will interfere with normal glucose homeostasis resulting in diabetes and other complications. Brown adipose tissue (BAT) is a tissue with high rates of lipid oxidation, making it an ideal organ burn excess fuel to control body weight. Recently it has been shown that BAT exists in humans being predominantly present in lean, young healthy humans opposed to humans that are obese.Typically BAT is activated in cold exposure to increase body temperature. This signal is mediated via activation of transient receptor potential channels (i.e. extreme-cold receptor transient receptor potential channel member A1(TRPA1)) in nerve endings. The cold signal then reaches the hypothalamus via afferent neuronal pathways. Via activation of certain cerebral nuclei, a sympathetic response is produced that reaches end organs such as BAT. TRPA1 can also be activated by allyl-isothiocyanate (AITC, present in mustard). AITC in animal studies induces energy expenditure. The end transient receptor potential cation channel subfamily V member (1 TRPV1), is an other receptor that activates energy expenditure via the natural compound capsaicin.We suggest that the activation of BAT is a promising target to increase energy expenditure in humans. The aim of this fellowship is to investigate the activation of energy expenditure via various protocols such as cold and the administration of AITC and capsaicin in healthy humans and obese subjects.Included subjects will undergo test protocols under two temperature conditions (thermoneutrality and cold), AITC and capsaicin administration. In these protocols we will also assess the role of the sympathetic nervous