RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Clinical validation of prognostic biomarkers of chemotherapy response in liquid biopsies' (SENSITIVITYMARKERS), addressing dissemination and exploitation.

assistant: **Impact**

The lack of clinically validated biomarkers to properly select patients for treatment with anti-cancer agents remains a major problem. Patients are not always receiving the most optimal treatment, resulting in poor response rates and high societal costs. By profiling more than hundred drugs on a broad panel of genetically characterized cell lines, researchers from NTRC have identified novel predictive drug response biomarkers for several anti-cancer agents. In the feasibility (Phase 1) study two of these genomic drug sensitivity markers will be validated using whole genome sequencing data of patients treated with the corresponding agents. In addition, a protein kinase that is involved in glucocorticoid resistance in T-cell leukemia will be validated. Proliferation assays will be carried out with blood samples from leukemia patients using proprietary inhibitors that NTRC has developed against this kinase. After successful completion of Phase 1, the project will be extended to other drug sensitivity markers identified by cancer cell line profiling in Phase 2 of the project. In addition, assays to determine the mutant status of cancer genes in circulating DNA and miniaturized proliferation assays with patient blood cells will be developed. In the commercialization phase of the project, novel clinically validated biomarkers and assays for several anti-cancer drugs will be licensed to pharmaceutical and diagnostic companies. The results of the feasibility project will increase the value of NTRC’s biomarker discovery platform, resulting in a doubling of turn-over within two years. In addition, novel IP will be generated and licensed to pharmaceutical and diagnostic companies. After six years an ROI of seven times the initial investment is estimated. Overall, the project will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Location of Cellular Users for Emergency Services' (LOCUS) targeting Fifth Framework.

assistant: **Abstract**

The objective of this project is to provide the EC with support and expertise regarding the definition of a future Emergency Call Service (ECS) in Europe taking into account all aspects of a future implementation such as: user needs, institutional issues, technical and technological issues, foreseen markets and convergence with other applications. This will participate to the guidance of EC policy development regarding the most relevant European regulatory framework for Enhanced 112 Emergency services.Work is split into 4 main technical workpackages:WP 1000: Overview of Location Services,WP 2000: Definition of Enhanced 112 services,WP 3000: Implentation Options,WP 4000: Recommendation.Outputs of these WPs will provide: An up-to-date overview to Location Systems, a definition of ECS services for Europe, an analysis of the implementation issues for such systems and recommendations regarding further implementation initiatives at EU or national level.Objectives:The objective of this accompanying measure is two fold:1) To contribute to the definition of the most relevant regulatory framework for the tentative European wide deployment of Enhanced 112 Emergency services by 1st January 2003 through:a)The outline, prioritisation and introduction of findings and recommendations (mainly concerning user needs, technical, institutional, organisational, financial aspects) regarding the definition and implementation options for Enhanced 112 Emergency Servicesb) The outline, prioritisation and introduction of findings and recommendations (mainly concerning user needs, market, technical, institutional and organisational aspects) regarding the fully commercial provision of assistance services, in the context of the possible European-wide deployment of Enhanced 112 Emergency services.c)Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Discovery Festival 2012 - Science meets nightlife in an innovative festival with live science, cutting edge art and top notch music. For the first time in 3 cities all over the Netherlands'.

assistant: **Concept**

Seen through the eyes of our 6000 visitors on Sept 28 2012, Discovery Festival is a unique night out, with experiments in new science, new art and new music. You can contribute to live science, enjoy art, see performances, hear talks, have drinks, play games, dance to live music and DJs - among young people, in a party atmosphere. Through the eyes of a science communicator Discovery Festival, the Dutch edition of the 2012 ERN, is an innovative event that reaches an important, difficult target group by combining new science and young scientists with a high quality art program and top notch nightlife activities. After 6 successful editions in Amsterdam, this year Discovery Festival will expand its horizon to 3 cities all over the Netherlands. This means a significantly larger and broader audience and impact. To facilitate this growth, we expand our organisation and include some excellent new partners in the 3 event cities.We aim to improve the public image of ‘the scientist’, by seducing people to associate ‘science’ and ‘scientist’ with values like ‘new’ and ‘creative’ instead of, ‘serious’ and ‘dull’. To achieve this, the event has three focuses that distinguish it from more traditional approaches. Firstly, we consciously pay attention to the person of the scientist and the process of science. It is about the ‘who’, the ‘how’ and the ‘why’, not just the ‘what’. Secondly, we explicitly define our target group to be broader than just the visitors of the event. We use the media to reach more people with the messages ‘Young scientists organise a trendy festival’ and ‘Science can be great content for a night out on the town’. To achieve that, we need to be sure Discovery Festival is taken seriously as a trendy nightlife event. Which is why, thirdly, we take the nightlife par
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Ranking for European road safety'.

assistant: **Objectives**

The objective of RANKERS is to develop comprehensive and practical guidelines for road infrastructure safety to enable optimal cost-effective decisions by road authorities and road operators in their efforts to eradicate dangerous road sections and promote sustainable roads.Specifically, these guidelines will cover:- A comprehensive and practical catalogue of scientifically-researched road infrastructure safety recommendations ranked according to their efficiency, and- An index used for assessing and monitoring road safety.RANKERS is unique in that it proposes addressing the infrastructure safety pillar in its interrelation with driver behaviour and vehicle design, by means of extensive data collection and analysis, field tests and virtual testing. Until now, important gaps in Europe's research efforts have prevented showing the tangible results that an integrated approach to road safety could unleash.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Modelling Of The Non-LTE Chemical Kinetics And Radiation Coupling In The Earth's Atmosphere' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The proposed research is concerned with the development of a fundamentally new approach for the modelling of chemical kinetic and radiative transfer processes in the atmosphere to cater for situations where non-local thermodynamic equilibrium (NLTE) effects occur. Such issues are important in the determination of atmospheric composition using satellite measurements and in understanding basic chemical kinetic processes. The new approach is a unique quantum level chemical reaction model which does not use rate expressions for the individual transition probabilities. Instead, it is based on statistical thermodynamics using the concept of Maximum Entropy (ME) to determine the outcome of a multi-species. Multi-step reaction and multi-level energy exchange mechanism. It offers the benefit of fully coupling the interdependent energy exchange and chemical reaction probability and can cater for complex conditions. It overcome several limitations of current atmospheric chemical kinetic schemes, natobly chemical rates generally assume LTE internal energy distributions and also the implicit assumption that post reaction internal energy disposal is also LTE. In addition, in existing schemes it is usually only possible to treat a subset of the reactions since a fully coupled state-to-state rate model for all of the reactions is prohibitively computer intensive. Since the ME scheme provides NLTE excited state information directly, it can be linked to transition probability models. This makes it especially attractive to use in schemes where radiative transport and coupling needs to be considered. It is expected that the new model will lead to a more accurate determination of atmospheric chemistry kinetic processes and composition and give a better understanding of the importance Of NLT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Photonic sensing of hydrocarbons based on innovative mid infrared lasers' in the context of a Seventh Framework call.

assistant: **Objectives**

The SensHy proposal focuses on novel photonic gas sensors for the detection of hydrocarbons. Hydrocarbons can be detected most sensitively in the 3.0 to 3.6 µm wavelength range. Two particular challenging applications with significant market potential are investigated within the project. Unfortunately there are no application grade semiconductor lasers in this wavelength range yet: On the short-wavelength side of this range interband lasers are available (RT cw operation for emission up to about 3.0 µm), while intraband quantum cascade lasers were demonstrated on the long-wavelength side (RT cw operation for emission above about 3.8 µm). An additional complication for applications in gas detection is given by the maximum available tuning range for suitable mono mode laser diodes, which is currently limited to a few nanometers. Concepts for an increased tuning range have so far been predominantly investigated at wavelengths around 1.55 µm for telecom applications. The aim of the SensHy proposal is to overcome these limitations and to achieve the following goals:<br/>- realize GaSb based laser material enabling RT cw operation in the wavelength range from 3.0 to 3.6 µm- develop multi-section DFB/DBR Lasers with increased electrical tuning capability- demonstrate highly sensitive hydrocarbon detection making use of widely tuneable lasers and novel digital-signal-processing schemes to identify various gas constituents within a multi-component hydrocarbon gas mixture<br/>In order to reach these goals significant challenges have to be overcome in various fields ranging from epitaxial semiconductor growth via laser design and processing to mid infrared sensor development of the project. For this the consortium comprises renowned research groups, academic and industrial partner
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'CREATION OF VARIETIES AND TECHNOLOGIES FOR INCREASING PRODUCTION AND UTILISATION OF HIGH QUALITY PROTEIN FROM THE WHITE LUPIN IN EUROPE' to be submitted under Fourth Framework.

assistant: **Abstract**

The ability of the white lupin to fix atmospheric nitrogen and to solubilize the mineral phosphorus makes it a very good candidate as an alternative crop for low-input and environment-friendly agriculture. The composition and quality of its grain make it an ideal candidate crop for the production of high-quality protein in Europe to substitute for considerable imports of soya, and as a potential source of new raw materials for human food industries.The objective of this proposed project is to bring together and coordinate existing European research on various aspects of breeding production and utilisation of the white lupin in a concerted effort to develop improved varieties capable of initiating and sustaining production from lupins within the European Union, and to develop industrial technologies that will improve and increase the utilisation of their grain and its products by industry. The project partnership includes research centres in genetics, agronomy and animal science and also private breeders and feed- and food-compounding industies.In the course of the project, new autumn-sown, genotypes that combine a determinate growth habit and dwarfism will be established and tested in a range of environments. The present level of genetic homogeneity in the F5 generations makes this readily achievable within the lifetime of the project. The more recently identified lime-tolerance character will be incorporated into spring-sown genotypes and autumn-sown, dwarf-determinate genotypes and tested in a wide range of environments during the course of the project. Appropriate technologies for gene transfer into the dwarf-determinate genotypes will be adapted from the techniques used on Lupinus angustifolius and used for transfer of a gene encoding for a sulfur-rich protein (Task
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Molecular pathogenesis of infection with human tumorviruses: interaction of viral genes with cellular targets'.

assistant: **Concept**

-To identify and characterize the main cellular targets for proteins encoded by the human viruses EBV, adenovirus, HPV-16 and HTLV-I-To investigate the interference of viral proteins with cellular signal transduction and cell cycle regulatory pathways-To study the influence of viral gene products on cellular gene expression and cell differentiation-To analyze the potential of viral proteins to modulate the apoptotic response of their host cellsSummary:Viral infection is involved in the pathogenesis of several cancers in humans. Among those, malignancies associated with human papillomaviruses, Epstein-Barr virus and human T-cell leukemia virus are of significant clinical importance, and particularly as secondary infections in immunosuppressed patients. We plan to analyze the molecular basis for the pathogenic effects of these viruses, which is largely unknown. There is evidence that infection by these viruses' influences a number of regulatory pathways, which control proliferation, differentiation, and survival of the host cells. Several cellular targets have now been identified for each of these viruses: Viral oncoproteins have been shown to interfere with various signal transduction pathways, to inactivate growth-suppressive nuclear proteins by direct binding, and to modulate the expression of key cell cycle regulatory genes. Furthermore, some viral oncogenes act by modulating the function of pS3, thereby influencing the apoptotic response of their host cells. Although some of these interactions have been analysed in considerable detail, a systematic analysis of these interactions is lacking. It is a major objective of the present proposal to analyse the possibility that common pathways are used by the different viruses to override growth control.Special attention will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Catalysis by gold' (AURICAT).

assistant: **Concept**

The primary training is in the fields of homogeneous & heterogeneous catalysis, catalytic reaction engineering and catalysis by gold. In addition to specific specialist training, several courses will be given on advanced topics in the field: eg. density functional theory, TAP reactor methods, XPS,chemical vapor deposition, EXAFS, Surface Science exptl. modeling of catalysts, gold chemistry, zeolite & mesoporous solids as catalyst supports, advanced catalysis engineering and industrial issues such as patenting, IPR & project management. Four major chemical companies (Degussa, Johnson Matthey, ICI Synetix & Sad Chemie are members of this network and will contribute a valuable industrial perspective. Each young researcher will work for three short periods in industry. Training will also be given in project management, all aspects of scientific communication, IT, and the language and culture of the host country. The nature of the project will in addition foster team-working skills in a multidisciplinary network. The young post-docs will be given roles in the management of the themes and the network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Towards a unified theory of protein structural fragments and their application for protein engineering and misfolding related diseases (protein folding fragments)'.

assistant: **Innovation**

Due to the systematic sequencing projects, the gap between the number of available protein sequences and structures increases, and the need for developing global proteomic programs becomes crucial. In this context, the prediction of new folds from scratch and the identification of characteristic folding fragments are necessary steps towards rational protein engineering and the elucidation of diseases related to misfolded structures. All the groups involved develop in silicon methods for determining protein structural subunits likely to correspond to key elements in the folding process. Our objective is to combine the expertise of the different groups and to transfer ideas and results in view of improving the efficiency of the individual approaches and establishing a synergetic prediction scheme of protein structure from sequence and conversely.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multifunctional Structures' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The needs to reduce cost and provide added value by integration of functions is demanding for a weight and volume constrained design onaircraft and satellite. On the last years, lightweight composite materials have been increasingly used to reduce the structural weight andvolume of equipment components. However, concentrating solely on structural mass reduction does not lead to further lowering ofequipment mass because the structure typically represents as little as 10 to 15% of the total mass. The envisaged solution is to designstructural elements that can integrate multiple functions, known as multifunctional structures, MFS.In the conventional avionics equipment design, structural, thermal and electronic functions are generally designed and fabricated intoseparate elements:Load support based on shells and metallic frames structuresThermal management based on radiators or cold platesElectronics enclosures based on metallic black boxes and rigid PCBElectronic/power distribution based on Cables bundles / harnessThese functions intend to be integrated under the MSF design, consisting in structural composite panels and composite housings that haselectric properties ( Patch within flexible integrated circuits mounted directly on the composite panel) and thermal properties ( heattransfer elements embedded on the composite panel as thermal doublers and straps made of high conductive graphite fibres oralternatively active thermal integrated refrigeration circuits as fluid loops).The proposal objective is the development of lightweight -fully integrated advanced equipment for aircraft and spacecraft (avionicselectronic housings) based on these multifunctional structures with disruptive design concepts. It is propose an innovation type of project,specification focused, within a