RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Safeguarding Cell Identities:   Mechanisms Counteracting Cell Fate Reprogramming' under Horizon 2020.

assistant: **Concept**

Regenerating tissues by reprogramming cells has the potential to become a therapeutic approach for replacing lost tissues in patients suffering from injury or degenerative diseases such as Alzheimer’s or Muscular Dystrophy. Strategies to generate required tissues using embryonic stem cells or induced pluripotent stem cells (iPSCs) are associated with either ethical or medical safety issues. An alternative strategy is to directly reprogram cells to the required tissue type by forced expression of cell fate-inducing transcription factors (TFs). Direct reprogramming (DR) has the potential to circumvent unsafe proliferative pluripotent cell stages and it allows in vivo procedures. However to date, DR is successful in only a few cell types and it is not well understood why most cells are refractory to DR. Recently, we provided evidence that inhibitory mechanisms play an important role in restricting cell fate conversion. We identified factors inhibiting direct conversion of germ cells into specific neurons or muscle cells. Additionally, preliminary studies in our group revealed other factors that inhibit ectopic cell fate induction in somatic cells. The objective of this proposal is to further understand mechanisms that restrict DR. We aim to identify and characterize factors involved in safeguarding differentiated cells and thereby counteract induction of ectopic fates in different cells. We use C. elegans as an in vivo model and apply large-scale forward and reverse genetic screenings with high-throughput. Next generation sequencing, tissue-specific biochemistry (ChIP-seq, SILAC) and 4D imaging will be used to elucidate the molecular function of identified DR-regulating factors. Finally, we will test the ability to convert cells in aged animals and assess the effects of ag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bratteli diagrams and dimension groups of substitutive zd -subshifts' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content The main purpose of my research project is to deepen my knowledge on the orbit structureOf continuous Zd-actions on Cantor spaces. I will mainly focus my attention to substitutive Z2-subshifts. First I would like to find 'good' Bratteli-Vershik models for these subshifts,i.e Bratteli-Vershik models where the dynamic can be encoded, then to characterize these Z2-subshifts with respect to their Bratteli-Vershik models. This work would certainly lead to know whether substitutive Z2-subshifts are orbit equivalent to substitution Z-subshift or not. Moreover if I could describe the dimension groups of substitutive Z2-subshifts I expect a very short proof of the so-called Cobham-Semenov Theorem, already proved,and to generalize this result to Bertrand numeration systems. This theorem lies between theory of automaton and arithmetic. This would be a very astonishing application of the Bratteli diagrams and of the dimension groups. Training content (objective, benefit and expected impact) The theory of C*-algebras is closely related to the orbit equivalence relation hence I would like to be introduced to its key concepts. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'FAcilitating Regional CROSS-border Electricity Transmission through Innovation' (FARCROSS) targeting Horizon 2020.

assistant: **Abstract**

To achieve its energy goals EU needs to establish a geographically large market by initially improving its cross-border electricity interconnections. A geographically large market, based on imports and exports of electricity, could increase the level of competition, boost the EU’s security of electricity supply and integrate more renewables into energy markets. Electricity should, as far as possible, flow between Member States as easily as it currently flows within Member States, so as to increase sustainability potential and real competition as well as to drive economic efficiency of the energy system. To this end, FARCROSS aims to address this challenge by connecting major stakeholders of the energy value chain and demonstrating integrated hardware and software solutions that will facilitate the “unlocking” of the resources for the cross-border electricity flows and regional cooperation. The project will promote state-of-the-art technologies to enhance the exploitation/capacity/efficiency of transmission grid assets, either on the generation or the transmission level. The hardware and software solutions will increase grid observability to facilitate system operations at a regional level, exploit the full potential of transmission corridors for increased electricity flows that will facilitate transition to flow-based regional market coupling, consider cross-border connections and their specific ICT and grid infrastructure, planning to use a wide-area protection approach to ensure the safe integration of renewable energy sources into the grid, mitigate disturbances, increase power system stability. An innovative regional forecasting platform will be demonstrated for improved prognosis of renewable generation and demand response and a capacity reserves optimization tool
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'IMAILE' to be submitted under Seventh Framework.

assistant: **Abstract**

In line with the FP 7 call for proposals the objective of IMAILE is to use the PCP process to identify new technologies and services which address the challenge of providing the next generation of Personal Learning Environments (PLE) for primary and secondary school.<br/>This common challenge is identified by the consortium in order to meet an increased demand of personalized learning in the 21st century European classroom.<br/>The next generation PLE should address students within the topics of Science, Math and Technology (STEM) and support different learning styles in an individualized way. Furthermore the PLE should be accessible from any device and therefore adjustable to the method bring your own device (BYOD).<br/>The main tasks of the project is to prepare and create a mutual understanding of the PCP method for the public procurers, execute a joint PCP European call and enable the research/development of PLE solutions from different suppliers evaluated through a common set of joint criteria.<br/>The PCP process and the PLE technology as a whole will be evaluated during the project in an open dialogue between public procurers and industry.<br/>The learning process contributes to set European standards within learning technologies as well as present an innovative PCP strategy for increased quality and efficiency of public procurement.<br/>The IMAILE project is offering a direct solution to both demand- and supplier side within learning technologies.  The solution is developed and evaluated according to the customized needs from the demand side. While the suppliers gain a solution adoptable directly on the European market.<br/>This action will in a long term perspective contribute to a broaden and innovative use of learning technologies in primary/ secondary educat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Specificity of translational control during unfolded protein response' (TRANSLATE), addressing dissemination and exploitation.

assistant: **Impact**

Unfolded protein response (UPR) is activated by multiple types of cellular stress, and can promote either cell survival or apoptosis. The balance between these opposing outcomes is delicately regulated, and when lost, contributes to diverse diseases. UPR enables cells to halt general translation, while inducing translation and transcription of specific mRNAs that escape repression. Even though the general machinery controlling translation is well understood, several fundamental open questions remain: 1) how are mRNAs selected for translation during UPR, 2) what role does mRNA structure and sequence play in this selection, 3) what role does UPR pathway play in the highly differentiated cells, such as neurons? My lab employs an integrative approach to understand how RNA-binding proteins (RBPs) control specific mRNAs. We recently developed hiCLIP, a method that globally quantifies interactions between RBPs and double-stranded RNA in live cells. Our preliminary findings demonstrate that a double-stranded RBP binds to structured motifs in mRNAs to control stress-induced translation. I propose to determine how combinatorial recognition of RNA sequence and structure by RBPs controls mRNA localisation, stability and translation during UPR. In addition, we will assess the role of UPR pathway in neuronal differentiation. Taken together, this study aims to elucidate how cells select specific mRNAs for translation, and thereby survive during stress or respond to signals that control differentiation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'How is phosphoinositide 3-kinase beta regulated by G-Protein Coupled Receptors and by Rab-5?' (BETA).

assistant: **Innovation**

Many signaling pathways in human cells involve lipid recognition events. The phosphorylation state of these lipids is under the control of both lipid kinases and lipid phosphatases. The phosphorylated second messenger lipids recruit lipid adaptor molecules, which regulate fundamental cellular processes including cell survival, proliferation, motility, differentiation and intracellular trafficking. Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3’ hydroxyl group of inositol phosphate. The class IA PI3K family is associated with diseases including cancer, thrombosis, allergies and arthritis. Although it is clear that these PI3Ks are activated by Receptor Tyrosine Kinases (RTKs), PI3Kβ is the single member of the PI3Ks that is activated downstream of both RTKs and G-protein coupled receptors (GPCRs).Using a combination of X-ray crystallography, in vitro activity assays and cellular experiments, I want to characterise the mechanisms specific to PI3Kß regulation. A first step will consist in the determination of PI3Kß structures in complex with G-protein ßγ heterodimers and with the small GTPase Rab5. That structural information will serve as an invaluable framework for further design of in vitro and cellular experiments to interrogate the exclusive mechanism of PI3Kβ regulation.Because of the potential role of PI3Kβ in oncogenesis and thrombosis, I will also determine the structures of PI3Kß in complexes with a panel of PI3K isoform-specific inhibitors. These structures will provide the basis for the next generation of therapeutics.This project will weave threads of structural, biophysical, biochemical and cell biology into a tapestry that depicts the roles of this unique enzyme that stands at the cross-road of RTK and GPCR signallin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Green corrosion inhibitors of metals' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Use of inhibitors is an important task in the protecting of metals form corrosion. Up to now the majority of the used metal corrosion inhibitors is toxic for human being and environment. The aim of the project is to elaborate and produce nontoxic adducts for protecting of metals to water and non-water media (such as paints, antifreezes) using nontoxic boron-coordinated compounds. It has been shown that these compounds are effective corrosion inhibitors and maintain their effectivity within the wide temperature range and effective under both dynamic and static conditions. The project aim is the synthesis of these compounds, study of their properties, trials of their corrosion properties in accordance with European standards, their wide-scale production and sale in EC countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Emergent Spacetimes' under Seventh Framework.

assistant: **Concept**

In this application we investigate the possiblity that spacetime geometry may be an emergent phenomenon. This ideas have been motivated by the Analogue Gravity programme. An ""effective gravitational field"" dominates the kinematics of small perturbations in an Analogue Model. In these models there is no obvious connection between the ""gravitational"" field tensor and the Einstein equations, as the emergent spacetime geometry arises as a consequence of linearising around some classical field. We present several projects that contribute to the field, and address issues of value for condensed matter physics, quantum field theory and general relativity.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'LEVITATION AND PROPULSION SUBSYSTEMS FOR SUSTAINABLE HIGH-SPEED MAGNETIC LEVITATION HYPERLOOP SYSTEM' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Over the years, transport of people and goods has become a key part of an increasingly globalised economy, reaching avalue of €4.14 Trillion in 2017, a 6% of the Gross World Product.However, this expansion has not been trouble-free, and the infrastructure congestion, pollution or oil dependence havebecome issues to be solved in order to carried out transport in a sustainable manner. That is why in 2013 the concept ofhyperloop has been created, a transport system based on pods that travel inside a tube with close to vacuum conditions;which allows it to reach 1,000 km/h, combining the speed of the plane, the convenience of the train and the periodicity of themetro making far journeys faster and more comfortable.Despite its potential, the development of an Hyperloop system is a long-term project that will require the collaboration ofdifferent companies to overcome the various challenges that will arise, especially related to the scalability of their systems,the cost reduction and the operation of Hyperloop at a higher level. These challenges are mostly three: the very high cost ofthe infrastructure construction, the manufacture of vehicles and the improvement of the internal systems of the vehicle,especially propulsion and levitation, with the aim of optimizing them for the future complete scalability of the Hyperloopconcept while ensuring the safety of passengers and cargo.Our solution to ensure this scalability involves an approach to levitation and propulsion subsystems that diverge from thestate-of-the-art, thus allowing reduced infrastructure costs, simpler maintenance, safer pressures and reduced energyconsumption.Zeleros Global was founded in 2016 by a group of hyperloop experts for the definitive development of the transport systemin Europe. Its team has won severa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'TRAINING FOR MODELLING THE GROUNDWATER ECOSYSTEM', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

All members of the groundwater biotic community, comprising microorganisms, protozoans, and metazoans, potentially contribute to the natural attenuation of organic matter inputs deriving e.g. from contaminations. Since an increasing proportion of drinking water is won from groundwater, bioremediation is important for public health. Sampling groundwater however is limited compared to other habitats. Therefore modelling takes an important part in increasing conceptual knowledge on the conditions under which microbial colonies, or the protozoans and metazoans grazing on the microbes, function most effectively. Groundwater contaminant biodegradation by microbes has so far only been modelled on the population level. These models have to make average assumptions which do not represent groundwater heterogeneity adequately. Biotic features, such as the adaptive behaviour that individual microbial cells exhibit by e.g. due to changing environmental conditions, have also not been taken into account. For other communities and other environments, such behavioural adaptations have successfully been modelled using the bottom up approach of individual-based models. The research project will therefore bring together an individual-based modeller, a groundwater ecologist and hydrogeological modellers to perform simulations based on exemplary conditions in order to evaluate the biodegradation potential based on the complete ecosystem functioning. The three main aims of this project are: 1) to adapt an existing platform for individual based modelling (IbM) of biofilm, iDynoMiCs, to groundwater conditions; 2) to add further levels of the food web and functional types to this platform, e.g. grazers (belonging both to the protozoans and metazoans), and 3) to couple this platform to a groundwa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Flame retardant Nanocontainers' (NOFLAME).

assistant: **Innovation**

Since we live in the polymer age, and polymers are highly inflammable, flame retardants have become a key component in industry to reduce the impact of fires. Flame retardants save people's lives, their property and in some cases even the environment.  However, traditional flame retardants like halogenated compounds present some serious disadvantages, like environmental persistence and toxicity, and their use is currently limited by REACH (EC 1907/2006). Halogen-free flame retardants like organophosphorus compounds or metal hydroxides, on the other hand, deteriorate the mechanical properties and have poor effectiveness. In this area, nanotechnology provides us some badly needed new approaches. In NOFLAME, we will explore a new approach based on the development of polymer flame retardant nanocontainers with high thermal stability, low flammability and good compatibility with polymeric matrices. These nanocontainers will help solve the problems of poor dispersion and low interfacial adhesion of the inorganic and hybrid nanomaterials applied so far. Furthermore, the ability to encapsulate a wide range of substances makes them highly attractive to develop multifunctional nanomaterials. The main activities within NOFLAME are: 1) the synthesis of several nanocontainers and the encapsulation of organic and inorganic flame retardant compounds, 2) the introduction of the nanocontainers in the polymer matrix and 3) the evaluation of their influence on the mechanical and flame retardant properties of the final material.  Combining their expertise for NOFLAME, the fellow Dr. Maria Velencoso, the host MPIP and the partner BAM will execute a thrilling research project to produce novel flame retardant nanomaterials and meet an urgent need of the European plastics industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Fast intelligent defect recognition system (FINDER)' (FINDER).

assistant: **Concept**

The development of an advanced and flexible inspection solution able to identify various esthetic defects on complex reflective forms, to carry out failure cause diagnosis of imperfections and to take intelligent and confident decisions in conformity with a new reference methodology of appearance defect classification, is the proposed innovative solution for resolving the urgent problem of vehicle headlamp reflector concerning quality inspection and manufacturing process reliability with important economic and environmental consequences. The completely new principle for a flexible (considering the product, production line, defect type, interfaces), nearly universal" esthetic defect detection (considering the complexity of car reflector) device is probably the most ambitious challenge of this project able to accelerate significantly introduction of automatic esthetic defect inspection in many industrial sectors."