RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Understanding Deep Learning' (2021-2027).

assistant: **Innovation**

While extremely successful, deep learning (DL) still lacks a solid theoretical foundation.In the last 5 years the PI focused almost entirely on DL theory, yielding a strong publication record with 7 papers at NeurIPS (the leading ML conference), including 2 spotlights (top 3% of submitted papers) and one oral (top 1%), 2 papers at ICLR (the leading DL conference), and 1 paper at COLT (the leading ML theory conference). These results are amongst the first that break a 20 years hiatus in NN theory, thereby giving some hope for a solid deep learning theory. This includes 1) the first poly-time learnability result for non-trivial function class by SGD on NN, 2) the first such result with near optimal rate, 3) new methodology to bound the sample complexity of NN, that established the first sample complexity bound that is sublinear in the number of parameters, under norm constraints that are valid in practice, 4) an explanation to the phenomena of adversarial examples.We plan to go far beyond these and other results, and to build a coherent theory for DL, addressing all three pillars of learning theory:Optimization: We plan to investigate the success of SGD in finding a good model, arguably the greatest mystery of modern deep learning. Specifically our goal is to understand what models are learnable by SGD on neural networks. To this end, we plan to come up with a new class of models that can potentially lead to new deep learning algorithms, with a solid theory behind them.Statistical Complexity: We plan to crack the second great mystery of modern deep learning, which is their ability to generalize with fewer examples than parameters. Our plan is to investigate the sample complexity of classes of neural networks that are defined by bounds on the weights’ magnitude.Representat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Transcription factors and regulation of AQP expression in maize stomatal guard cells and subsidiary cells'.

assistant: **Innovation**

The stomata are openings formed on the epidermis formed by two guard cells (GC) surrounded by subsidiary cells (SC), allowing gaseous exchange for photosynthesis at the expense of water via transpiration. Stomata are tightly regulated by the influx and efflux of water and small solutes across GC or SC membranes. The diffusion of these solutes and water through the membranes can be facilitated by aquaporins (AQPs). While there is insufficient knowledge on the precise role of AQPs in stomata, specific microdissection of the mechanism of AQP action in GCs and SCs affecting stomata is further limited. The superiority of grass stomata owing to their quick response make them apt for studying the role of AQPs in stomatal response, especially under abiotic stress condition since climate change has made crops worldwide extremely vulnerable. In this regard, maize is an appropriate grass crop to use as a model because of its economic importance. The overall goal of this project is to study the role of different AQPs, and their transcriptional regulation in stomatal complexes, that can be used to produce stress-resilient crops. We will be using transactivation assays, protoplast engineering, maize suspension cells, and CRISPR/Cas to achieve the objectives. The mechanisms uncovered here can be monumental to extrapolate the grass stress resilience mechanisms into other vital crops. This project will help add the experience required for my goal of being an independent group leader. I will gain from the scientific environment and the infrastructure and support system at LIBST-UCLouvain as well as from the vast experience of Prof. Chaumont in research and project management. In turn, the host will benefit from the technical skills, and creativity that I can offer.


**Keywords:** Aquapo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Polish Network of Mobility Information Centres (PL-MOC NETWORK)' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

In order to improve the living and working conditions of mobile researchers in Europe, the European Commission has initiated the creation of the European Network of Mobility Information Centres. The Polish Ministry of Scientific Research has recognized the above-mentioned initiative and appointed the NCP-Poland to submit the proposal which aims at establishing the Polish Network of Mobility Information Centres (PL-MoC). The main objective of the 3-year project is to offer researchers and their families comprehensive and up-to-date information and personalised assistance in all matters relating to their professional and daily lives (visa, work permit, social and health security, pension rights, taxation, apartment rental or housing, language courses, childcare facilities and schooling, culture and leisure activities, etc). This objective will be achieved by joint efforts of the already existing organisations within the Polish network of Contact Points since new responsibilites of complementary assistance to mobile researchers, host institutions and public administration will be assigned to them. The network will be managed by the Bridgehead Organisation and 10 regional Mobility Centres. Thus, the structure of the work plan and the overall methodology of the project have been designed in order to achieve the core objectives resulting from the thorough mapping exercise. Firstly, the reliable sources of information will be identified and information collected. On that basis, the national and regional web-sites for mobile researchers will be developed. Furhtermore, the proximity assistance will be offered by well-trained and professional personnel of MoC network (help-desk). The entire PL-MoC network will be widely recognized thanks to promotional and awareness-raising campa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development, Construction and Integration of Bench Systems for Ground Thermal Tests' to be submitted under Seventh Framework.

assistant: **Abstract**

The work within BESTT is allocated within seven work packages which lift the current know-how and demands for technological solutions step-by-step to a new innovative level. The consortium, consisting of three experienced companies covers the capabilities of developing and implementing a complex test bench by their experience in the field of manufacturing and standardisation (TEMES), modelling and engineering of complex plants (Modelon) and development and implementation of complex test benches (Streit). The development process will be created by this interdisciplinary experts consortium in an innovative iterative way which means, that short development cycles will go through the evaluation of an industrial manufacturer, a specialist company for test bench construction and a modelling experts company that will be the mathematic backbone on the way to the best solutions. Based on the results of the first work package a detailed planning process will be executed in WP2 “Design”. After the construction of the different custom parts in WP3, the integration of these components into the test facility will be carried out. To guarantee the operational functionality of the test bench, extensive operational tests will be executed by the consortium partners in WP5 “Operational testing"". With this consortium three strong expert companies will work together on the development of a step-change test environment for future technologies especially the more-electrical aircraft. The consortium will be managed by STREIT, which is an experienced engineering and plant construction company that already participated successfully in two FP projects.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Plasmodium falciparum Malaria: Exploring sub-telomeric genes with the novel proteomics method SURFEOMICS""' (2002-2006).

assistant: **Concept**

Malaria kills a child every 40 seconds. Up to 500 million malaria cases are estimated each year, resulting in more than a million deaths. The malaria parasite Plasmodium falciparum is one of the greatest health problems in the developing world. This project will test the hypothesis that the blood stage of the malaria parasite (merozoite) depends on multiple expressed ligands (rather than only one) for both adhering to and invading erythrocytes. Novel variable polypeptides termed SURFINs, which are encoded b y the surf-gene family, were recently discovered on both the infected erythrocyte (IE) and merozoite surface. In addition, other new gene families have been identified in the sub-telomeric regions of the P. falciparum chromosomes.The identification of the se polypeptides suggests that antigenic variation also occurs at the merozoite level and that the parasite coordinates antigen expression. Furthermore, it argues that multiple molecules have important roles in both IE adhesion and merozoite invasion into t he erythrocyte. Studies will focus on identifying new ligands using a proteomic approach termed 'surfeomics', which targets protein moieties displayed on the surface of live IEs. Parasite surface proteins are removed using a trypsin digest and identified by mass spectrometry. Results will be used to create a database containing parasite surface proteins linked to genomic data.This database will augment the existing PlasmaDB database and provide information on surface protein variation and its relationship to parasite strain, life stage, and virulence. This research will increase our understanding of malaria pathogenesis by combining in silico bioinformatics and in vitro molecular experiments. Expressed surface proteins are important in the ability of theme rozoite
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'INstitutional Transformation for Effecting Gender Equality in Research' (INTEGER) targeting Seventh Framework.

assistant: **Abstract**

The INTEGER project brings together a balanced and complementary consortium of organisations which share a top level commitment to the implementation of sustainable transformational change to improve the career progression of women scientific researchers. The consortium is made up of three implementing organisations - two Higher Education Institutions, Trinity College Dublin, Ireland, and the University of Siauliai, Lithuania, and a research institution, the Centre National de la Recherche Scientifique (CNRS), France, as well as  a specialist external evaluator, GESIS, the Leibniz Institute for the Social Sciences, Germany. The UKRC participated as a co-ordinator and external gender expert until month 14, followed by an interim from Bradford College, and their withdrawal, at month 18. Subsequently, the co-ordination will be ensured by CNRS, and the respective gender expertise role will continue to be provided by the gender units within each implementing organisation, with the input of an Expert Group and a network of Ambassadors.The project will utilise a simultaneous top down and bottom up approach to improve learning and engagement, and will ensure the lessons learned from delivery of other past and current projects is fully incorporated and built upon in the initial stages of implementation. The use of Transformational Gender Action Plans formed from established gender tools, tailored to individual organisations, fully and properly implemented down to the local level from senior management, and with measured outputs to promote, embed and mainstream gender equity within the participating organisations, will result in the desired outcome of improved career progression for women. Sustainability will be secured by bringing about the desired structural change across the r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'CHARACTERIZATION AND ASSESSMENT OF GENETIC APTITUDES OF EUROPEAN LOCAL BEEF CATTLE BREEDS FOR PRODUCING QUALITY MEAT' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Background :Meat production based on local beef breeds exploited in extensive grazing systems in less developed regions is an objective perfectly consistent with the priorities of the reformed CAP. Nevertheless, there is a great challenge for local beef breeds to ensure the production of quality meat in accordance to the consumer demands altogether with the sustain of the economic activity in these less favoured regions. Knowledge on minority local beef cattle breeds is very poor. A systematic research for the characterization of such breeds regarding their genetic potential for producing quality meat is warranted. In Spain, Portugal and France, there are a considerable number of local cattle breeds for which, there is little information on numbers, productivity, management system, genetic variability and carcass composition. The objective is :This proposal will describe from a multidisciplinary approach the above characteristics for 17 local breeds. Statistics on numbers, herds, productivity and management will be obtained by survey, the genetic structure of the breeds will be characterised by molecular genetic markers and analysis of growth performance, carcass and meat quality will be made in controlled studies. Short description of the project :The project will consist of three main parts:- Characterization of the production systems. This will done through updating and analyzing statistics, studying databases containing production traits records, and evaluating breeding goals after grouping breeds exhibiting similar production systems;- Study of the genetic structure of breeds and their relationships through  molecular genetic markers. The genetic structure will be described in terms of inter alia, gene flows, effective herd sizes, age structure, generation lenghts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Progeria models to study endothelial cell ageing: implications for organ regeneration and fibrosis' (EnCAge) under Horizon 2020.

assistant: **Objectives**

Capillary endothelial cells (ECs) are not just passive conduits for delivering blood. Rather, ECs also play tissue-specific functions by providing highly specialized sets of angiocrine factors that control tissue homeostasis, regulate stem cell self-renewal, and guide organ regeneration without provoking fibrosis. However, it is not known whether tissue-specific instructive functions of ECs are lost during ageing. Moreover, the causal role of EC ageing in age-associated tissue dysfunction has not been directly studied so far. The use of aged mice to study age-related tissue alterations and to develop new drugs is not practical, since it is expensive, time consuming and does not allow for high throughput screenings. Thus, it is key to develop more convenient experimental systems that recapitulate the phenotype of aged cells. Hutchinson-Gilford progeria syndrome (HGPS) is a rare disease caused by progerin, a mutant form of the nuclear protein prelamin A that induces premature ageing. Remarkably, HGPS mimics many of the characteristics of human ageing, and progerin has also been detected at low levels in aged tissues of non-HGPS individuals. Thus, HGPS experimental models have proven to be very useful for the study of physiological ageing. This proposal will study age-dependent and tissue-specific alterations in ECs using a mouse model of HGPS. Furthermore, the candidate will use mice with EC-specific expression of progerin to assess the causal role of EC ageing in age-related impairment of organ regeneration, modelled by liver repair after injury. Finally, the applicant will develop an in vitro system to identify mechanisms through which progerin-induced EC ageing may elicit fibrotic responses that could compromise organ repair, and to test compounds to prevent or reverse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Machine learning for diagnosis of bipolar disorder: detection of physiological digital biomarkers' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Bipolar disorder (BD) is a chronic and debilitating mental disorder, that affects 2-3% of the population. It impacts quality of life, cognition, and is a leading cause of suicide and all-cause mortalities. Most patients are taken into clinical care during acute episodes, which puts the burden on psychiatrists to make fast, yet accurate diagnostic decisions. However, unlike most medical conditions, psychiatric diagnoses are subjective. This paired with the complexity of its clinical presentation, BD is the most misdiagnosed and underdiagnosed psychiatric condition. More objective scales used in research lack clinical application, due to time constraints and high burden on the patient. AI-DIAGNOSE wants to disrupt the state of the art of BD diagnosis through a completely novel approach: developing an automatized and fast tool for objective detection of BD and psychotic symptoms based on physiological audiovisual biomarkers and machine learning (ML). The timing of the project is supported through recent evidence, from the host, the applicant, and others, showing that speech and eye movement are promising physiological biomarkers. In a pilot study, I found that ML algorithms based on speech patterns could predict the presence of psychiatric diagnosis, and differentiate patients with and without psychosis. Eye‐tracking datasets provide insights regarding information processing patterns, and have shown potential as diagnostic biomarkers. Although eye movement and speech patterns are promising biomarkers as they can be acquired fast and without putting high burden on the patient, they have not been combined yet for psychiatric diagnostic purposes. The project will be the first to develop such a multi-modal ML diagnostic tool for BD and psychosis in BD. We will test its accurac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Action Leveraging Evidence to Reduce perinatal morTality and morbidity in sub-Saharan Africa' (ALERT).

assistant: **Innovation**

Insufficient reductions in maternal and neonatal deaths and stillbirths in the past decade are a threat to achieving the Sustainable Development Goal 3. Overcoming the knowledge-do gap to ensure implementation of known evidence-based intervention during the intrapartum period – the period from onset of labour to immediately after childbirth – has the potential to avert at least 2.5 million deaths in mothers and their offspring annually. Our ALERT approach targets this period and will develop and evaluate a multifaceted health system intervention to strengthen the implementation of evidence-based interventions and responsive care in Sub-Saharan African hospitals, where 40-50% of all births in the region take place.  The ALERT intervention will include four main components: i) end-user participation through narratives of women, families and midwifery providers to ensure co-design of the intervention;  ii) competency-based training; iii) quality improvement, supported by data from a clinical perinatal e-registry; iv) empowerment and leadership mentoring of maternity unit leaders complemented by district based bi-annual coordination and accountability meetings. We will apply a gender lens to explore constraints in intrapartum care in the context of the multidisciplinary teams providing maternity care. Repositioning midwifery with its preventive, promotive and curative aspects is a cross-cutting theme. We will evaluate the intervention through a stepped-wedge design, the primary outcome being in-facility perinatal (stillbirths and early neonatal) mortality. Our nested realist process evaluation will help to understand what works, for whom and under which condition. An economic evaluation will report on scalability and costs. Our research aims to inform programming for the Su