RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Selective retention of VEGF for cancer and retinopathies therapeutics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Angiogenesis is the mechanism of blood vessel formation from pre-existing ones and is vital for nutrient and oxygen delivery to all cells in the organism. However, dysregulation of angiogenesis is detrimental for the organism. Excessive or abnormal angiogenesis is a hallmark of cancer and various retinopathies and favours tumour growth and metastasis, and vision loss, respectively. Excessive or abnormal angiogenesis is fuelled by hypoxia-driven expression of high levels of vascular endothelial growth factor (VEGF), the main pro-angiogenic molecule that stimulates the formation of new blood vessels.Although VEGF-centric anti-angiogenic therapies do exist, their efficacy is limited by their specificity and numerous side effects, hampering greatly their potential clinical benefits. Therefore, there is an urgent need for improved anti-VEGF therapeutic strategies.The aim of this PoC project is to identify a novel class of anti-VEGF drugs. We designed an innovative and unique screening method to identify an unexplored mechanism to inhibit VEGF function in vivo, which has the prospect of reduced toxicity and, thus, enhanced clinical efficacy. This project will enable the creation of a start-up company to commercialize the newly identified class of drugs for subsequent clinical development to curb cancer and retinopathies. We aim at improving patient survival and well-being, and reducing the economic burden associated with these diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unfairness in contracts and its effect in European contract law and international trade contracts' under Fourth Framework.

assistant: **Concept**

The project is a PhD research in the field of European Contract Law, aimed at determining the effect of unfairness in commercial contracts within the European Union, inter alia in light of EU Directive 93/13/EEC on Unfair Terms in Consumer Contracts. A comparison will be made to the rules regarding unfairness in regard to specific types of International Trade Contracts and the effect of unfairness in Private International Law. A Commission on European Contract Law is in the process of making an European Code of Contracts which is intended to harmonize the contract law within the EU and make business transactions within the Single European Market easier. Unfairness has been an invalidation reason in most of the EU countries in the past, and it is essential for the future use of the Code and European trade to understand the term unfairness in light of the legal use of the word in the EU countries hitherto.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Understanding the Role of Motors in Subcellular Mechanics of Organelles by Controlling Myo6-Cargo Interactions in situ'.

assistant: **Concept**

Mechanical forces play crucial roles in the formation and maturation of many organelles and membrane vesicles. Many of these forces originate in the action of cytoskeletal motors, but how these motors are activated and how their mechanical functions are regulated in the cell are poorly understood. Rather than being “always on” machines, motors must often be specifically activated for distinct mechanical roles by partners.The MELANCHOR project seeks to uncover how Myosin VI (Myo6) promotes two cell processes through specific interaction with partners that promote different Myo6 dimerisation modes with unique mechanical properties. Myo6:GIPC1 complexes aid in endosomal trafficking through the actin cortex while Myo6:Optineurin complexes  promote melanosome biogenesis through a membrane recycling pathway. Two complementary approaches will uncover the functions of Myo6. (1) Optogenetic tools will control Myo6 targeting to endosomes or melanosomes in live cells, with simultaneous functional imaging, to precisely localize the effect of Myo6 in space and time. (2) Novel in vitro motility methods will determine the effect of different Myo6 partners on Myo6 activation and mechanics under tension. Finally, a combined approach will address the mechanical role of Myo6 in these organelles– whether it is a tension-bearing anchor, transporter or weak tether.The MELANCHOR project raises the exciting prospect of using optogenetic tools to provide real-time information on subcellular mechanics. By integrating cellular and in vitro approaches to measure the tension in individual Myo6 motors, an unprecedented level of detail on the cellular function of motors will be made possible. These novel techniques will help shed light on motor function in processes such as intracellular trafficking,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Artificial Intelligence for the European Open Science Cloud' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The AI4EOSC (Artificial Intelligence for the European Open Science Cloud) delivers an enhanced set of advanced services for the development of Artificial Intelligence (AI), Machine Learning (ML) and Deep Learning (DL) models and applications in the European Open Science Cloud (EOSC). These services are bundled together into a comprehensive platform providing advanced features such as distributed, federated and split learning; novel provenance metadata for AI/ML/DL models; event-driven data processing services or provisioning of AI/ML/DL services based on serverless computing. The project builds on top of the DEEP-Hybrid-DataCloud outcomes and the EOSC compute platform and services in order to provide this specialized compute platform. Moreover, AI4EOSC offers customization components in order to provide tailor made deployments of the platform, adapting to the evolving user needs.The main outcomes of the AI4EOSC project will be a measurable increase of the number of advanced, high level, customizable services available through the EOSC portal, serving as a catalyst for researchers,  facilitating the collaboration, easing access to high-end pan-European resources and reducing the time to results; paired with concrete contributions to the EOSC exploitation perspective, creating a new channel to support the build-up of the EOSC Artificial Intelligence and Machine Learning community of practice.


**Keywords:** Compute platform, Artificial Intelligence, Cloud Computing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'FOSTERING PRECISION AGRICULTURE AND LIVESTOCK FARMING THROUGH SECURE ACCESS TO LARGE-SCALE HPC-ENABLED VIRTUAL INDUSTRIAL EXPERIMENTATION ENVIRONMENT EMPOWERING SCALABLE BIG DATA ANALYTICS' (CYBELE).

assistant: **Concept**

CYBELE generates innovation and create value in the domain of agri-food, and its verticals in the sub-domains of PA and PLF in specific, as demonstrated by the real-life industrial cases to be supported, empowering capacity building within the industrial and research community. Since agriculture is a high volume business with low operational efficiency, CYBELE aspires at demonstrating how the convergence of HPC, Big Data, Cloud Computing and the IoT can revolutionize farming, reduce scarcity and increase food supply, bringing social, economic, and environmental benefits. CYBELE intends to safeguard that stakeholders have integrated, unmediated access to a vast amount of large scale datasets of diverse types from a variety of sources, and they are capable of generating value and extracting insights, by providing secure and unmediated access to large-scale HPC infrastructures supporting data discovery, processing, combination and visualization services, solving challenges modelled as mathematical algorithms requiring high computing power. CYBELE develops large scale HPC-enabled test beds and delivers a distributed big data management architecture and a data management strategy providing 1) integrated, unmediated access to large scale datasets of diverse types from a multitude of distributed data sources, 2) a data and  service driven virtual HPC-enabled environment supporting the execution of multi-parametric agri-food related impact model experiments, optimizing the features of processing large scale datasets and 3) a bouquet of domain specific and generic services on top of the virtual research environment facilitating the elicitation of knowledge from big agri-food related data, addressing the issue of increasing responsiveness and empowering automation-assisted decisi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Impacts of antibody cross-reactivity on gut community ecology and vaccine immunogenicity' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Antimicrobial resistance (AMR) is a looming global threat, rendering antibiotic treatments useless, and making bacterial infections difficult to treat. With diminishing antibiotic options to control infectious outbreaks, we must develop new strategies to prevent widespread mortality. Our group develops novel vaccines to leverage the body’s natural immune responses to fight bacterial infections. To do this, it is crucial to understand how our immune systems recognize harmful bacteria (“pathogens”), and how they distinguish them from the ‘good’ gut-resident microbes which promote human health. Oral vaccines typically induce protective immune responses which recognize sugar structures on the outer membrane of harmful bacteria, promoting their elimination. However, some of these sugar structures use the same molecular building blocks as those found on the surface of beneficial bacteria. In fact, some pathogens mimic the sugar structures of beneficial microbes to evade the immune system. In turn, this may lead to inappropriate recognition of good bacteria by the immune system. I plan to combine vaccination studies in mice with molecular tools to study direct surface sugar-immune interactions, focusing on immune responses to World Health Organization AMR priority pathogens Salmonella and Shigella. I will answer fundamental questions about immune-bacterial recognition: (1) Can immune antibodies induced in response to harmful pathogens also recognize good bacteria? (2) Does this recognition impact the composition and host-beneficial functions of gut resident microbial communities? (3) Does non-specificity of bacterial immune targeting reduce vaccine-mediated protection? Outcomes will contribute to fundamental scientific knowledge of immune-bacterial interactions and provide val
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Real-Time IoT Stream Processing and Large-scale Data Analytics for Smart City Applications'.

assistant: **Objectives**

An increasing number of cities have started to introduce new ICT enabled services.  However, the uptake of smart city applications is hindered by various issues, such as the difficulty of integrating heterogeneous data sources and the challenge of extracting up-to-date information in real-time from large-scale dynamic data. Today the challenges are often addressed by application specific solutions, resulting in silo architectures.Bridging technology and domain boundaries, requires a scalable, adaptive and robust framework that provides:<br/> Virtualisation hiding the heterogeneity of the numerous data and information sources<br/> Large-scale data analytics for resource efficient event detection in multiple data streams<br/> Semantic description frameworks and semantic analytics tools to provide machine-interpretable descriptions of data and knowledge<br/> Easy creation of real-time smart city applications by re-usable intelligent components<br/>CityPulse will develop, build and test a framework for semantic discovery and processing of large-scale real-time IoT and relevant social data streams for reliable knowledge extraction in a real city environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The first superbot to audit calls' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Airlines, banks, electrical utilities, cable companies, wireless service providers and high-tech retailers rely on call centers to manage and response the massive amount of customer queries. However, there is a lack of detailed auditing from the brands to the contact centers to ensure the best customer engagement or it is only based on the manual and aleatory control of the calls. In every Call Center it is necessary to monitor calls to verify that voice interactions with clients or leads conform to the guidelines and policies of quality established by the company. While calls are abundant in useful data, it’s impossible to manually evaluate and analyze each one given their staggering volume. In fact, only about 1% of customer call data is assessed in random quality evaluation processes. Since quality monitoring is done manually by listening to random calls and since it’s impossible to review all the calls, only a small percentage of the recorded calls is being evaluated and much important data is lost. CLARA, is a Superbot capable of analyzing and interpret spontaneous conversations in real life conditions. CLARA is a proprietary technology of PREDICTIVA based on Deep Learning, a set of machine learning algorithms with multiple layers of nonlinear processing and learning representations of characteristics in each layer.CLARA Super Bot Speech Analytics offers a better way to leverage customer call data. The tool transcribes all recorded calls in their entirety, then analyzes the interactions using advanced speech detection technology. Through datamining these transcriptions, it allows to discover actionable insights for improving brand - and won’t ever worry about missing a detail again. CLARA offers a variety of must-have features to improve customer service experience
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'From Structures to Predictions: Precision Multi-jet QCD for LHC Physics'.

assistant: **Objectives**

With the start of the Large Hadron Collider (LHC) at CERN a new era of research of the fundamental laws of Nature has begun.  Discoveries, such as Dark Matter particles, the Higgs boson and a refined Standard Model of Particle Physics (SM) will be the backbone for fundamental research in many areas of physics for years to come.The proposed research contributes to this quest. We will provide precision theory predictions for the proton-proton scattering processes, thereby enhancing the discovery reach of the LHC experiments.  The interpretation of the experimenters' data requires the comparison to such theory predictions. In the absence of such predictions, new physics signals may remain hidden, or backgrounds may be falsely identified as exciting new physics.More concretely, we will make available precision simulations of the SM and, possibly, an extension thereof.  We focus on scattering processes with many final-state objects.  These processes are part of the new physics territory unlocked by the LHC and are a key to exploring new fundamental particles and phenomena.  The targeted precision requires the computation of at least next-to-leading-order quantum effects within perturbative quantum-field theories.  State-of-the-art physics studies, such as the production of tops, the Higgs boson, Z/W-bosons in association with jets, will kick start this research program.The research methodology will be to exploit mathematical structures of scattering processes in order to resolve present computational bottlenecks. The seeds of a new methodology to deal with the complexity of scattering processes has appeared only recently. In fact, key advances go back to a string inspired approach to scattering amplitudes by E. Witten and, most recently, by N. Arkani-Hamed.  Such methods hav
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'An eco-friendly ultrasonic system to control and prevent algal blooms and zebra mussel invasion in small and large water surfaces', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

An algal bloom is a rapid increase in the population of algae in an aquatic system and can be harmful for the environment, human health and aquatic life due to the production of toxins and the consequences of accumulated biomass. The zebra mussel is an increasingly problematic invasive organism found in waterbodies difficult to control due to their fast proliferation. Both invasive species can cause in fresh water systems taste and odour issues, operational problems by clogging filters and pumps and disrupt the ecosystem. There is an urgent need to efficient control their proliferation, since current methods are expensive, cumbersome and environmentally unfriendly. Solving systems engineering (S2E) is an advanced services enterprise in electronic engineering, specialized in integrated electronic system design, R+D projects and energetic advisory. We have developed a cost-efficient and eco-friendly floating buoy (BLACK HAT) based on ultrasonic technology to control and prevent algal blooms and zebra mussel plagues in small and large water surfaces. The system operates autonomously on solar energy, reducing electricity consumption, carbon foot print and operational costs. In addition, the device emits in a frequency bandwidth that kills efficiently different types of algae and zebra mussel without damage fish and plants.We have planned technical and commercial activities to ensure a success entry of BLACK HAT into the market. With BLACK HAT, we forecast a gross profit of  €23.8 million after five years of commercialization and the creation of 22 new positions within in our company to satisfy growth needs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Neural mechanisms of crossmodal activity in blind and sighted individuals' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Our ability to learn rests on the brain’s capacity to change. People who are blind since birth have to rely more strongly on the intact sense, hearing and touch, to interact with their environment. As a consequence, blind people often show superior abilities when it comes to discriminating sounds and touch. For example, they can distinguish different voices more easily. The blind brain shows large changes due to the lack of vision: the part of the brain that responds to visual input in sighted people is now activated by the processing of sounds and touch, which is called “crossmodal plasticity”. Not only blind people, but also sighted people sometimes show crossmodal activation of the visual cortex while perceiving sounds or touch. As many environmental events are multisensory in nature, e.g. we simultaneously see and hear a person, it is thought that all related sensory representations are activated in distributed networks across the brain – even if only one sensory input is received. The proposed project investigates, using the latest advances in ultra-high field imaging, the detailed underlying mechanisms of crossmodal activation of visual brain regions during voice perception in blind and sighted humans in order to understand how the brain adapts to experience.


**Keywords:** crossmodal plasticity, blindness