RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Reuse in component-based software engineering', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Software Innovation is a software company that bases it's business on sales of it's two off-the-shelf" products, SalesMaker and ProArc, and on development of customer specific solutions. Both products are targeted at the high-end market, SalesMaker mainly at large sales-organisations and ProArc mainly at document management in the offshore business. The company has experienced a rapid growth the last three years. Larger projects and larger project teams have been needed to meet the customers demand. This rapid growth has created a new environment, in which communication between development teams have been reduced and reuse is incorporated on an opportunistic level only. The purpose of this PIE is to achieve measurable improvements in the company's development process, through developing mechanisms that allow us to build reusable components and modules on a company wide basis. The goal is to arrive at increased quality, flexibility and productivity through both organised reuse and object oriented, component based system development.THE EXPERIMENTThe experiment is to change the existing development process to a well-defined component-based development process with emphasis on reusable components. An object-oriented system development method for client/server systems will be selected. The project management model will be adopted to incorporate reuse activities, resources and documentation, enabling the project managers of the two products to plan and track the baseline project. Metrics will be selected and then used to evaluate both the quality and the reusability of components. The improved development process will be applied to our baseline project, the development of new Win32 based versions of our two products. Software Innovation has 82 employees of which 50 are worki
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mutant p53 as target for improved cancer treatment' under Sixth Framework.

assistant: **Concept**

Mutations in the p53 tumor suppressor gene are the most frequent genetic alteration in human cancer, occurring in over 40% of all cases of cancer. One well-studied outcome of these mutations is the loss of the tumor suppressor activity of the wild type (wt) p53. However, there is growing evidence that many of the mutations that occur in the p53 protein in fact generate mutant p53 proteins (mutp53) that have acquired new biochemical and biological properties. Through this gain of function (GOF), mutp53 is believed to contribute actively to the cancer process. We propose to explore mutp53 as a target for novel anti-cancer therapies. Such therapies should aim to either abrogate the GOF effects of mutp53, or restore wt-like properties to mutp53, so that it can now regain its tumor suppressor capabilities. To achieve these ambitious aims, we propose a multi- disciplinary approach to explore and exploit the contribution of mutp53 to cancer. One component of this project will investigate in depth the molecular properties of mutp53: structural studies will pinpoint the changes that particular mutations inflict on the structure of p53, and allow the classification of mutp53 into distinct subclasses. In parallel, biochemical studies will explore the mode of action of mutp53 within cells, including its impact on patterns of gene expression, identification of specific DNA sequences targeted by mutp53, and discovery of mutp53-interacting cellular proteins. Preclinical models for mutpS 3-driven cancer will also be developed, as a critical instrument for pre- clinical studies. The other component will aim at translating this wealth of information into better cancer therapy. One part ofthat effort will address the clinical relevance of particular p53 mutations in human cancer, and part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Reducing Uncertainty in Performance Prediction' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

At the core of the safety case for long-term geologic disposal for spent nuclear fuel lie the issues regarding spent fuel dissolution. We have today significant knowledge regarding dissolution of uranium oxide in the laboratory. However, uncertainties remain regarding spent fuel dissolution under realistic conditions. Two main questions stand out as necessary to address: First, the synthetic groundwater used in the experiments to date does not contain all of the chemical elements that occur in natural groundwaters. Some of the trace elements may produce radiolysis products that are more aggressive than those produced in the synthetic groundwaters. Second, the fragments used in laboratory experiments contain sharp edges and defects generated by the crushing process. These sites contain atoms that have fewer bonds than the bulk material and constitute high-energy sites. As dissolution occurs, these sites dissolve faster than lower energy sites, such as plane surface sites. As the high-energy sites disappear through dissolution, the dissolution rate decreases. We can approach the long-term dissolution rate in the laboratory, but we cannot at this time estimate how far away we are from it. The two items mentioned above lead to uncertainty concerning the dissolution rate. The objectives of the work proposed here are to reduce the uncertainty in the dissolution rate to be used in the safety case and thereby increase the confidence that can be placed in our ability to demonstrate that the geologic repository will function as designed. A second objective of this work is to provide for the training of young research workers who can continue to support the research needed in the future concerning radioactive waste disposal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Best-Reliable Ambient Intelligent Nano Sensor Systems' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Best-Reliable Ambient Intelligent Nanosensor Systems – e-BRAINS – represent a giant leap for outstanding future applications in the area of ambient living with the ultimate need for integration of heterogeneous technologies, high-performance nanosensor devices, miniaturization, smart wireless communication and best-reliability.e-BRAINS with minimum volume and weight as well as reduced power consumption can be utilized in ambient living systems. Successful market entry of such innovative ambient intelligence products will be determined by the performance improvement achieved and the cost advantage in relation to the total system cost.The basic requirement for robustness and reliability of the heterogeneous integration technologies and the nanosensor layers is in the focus of all e-BRAINS developments.The designated nanosensor systems represent a very promising innovative approach with the potential to enable high-performance and precise functions in new products. The application of nanotechnology will allow large improvements in functionality and will open a wide range of applications for European companies.Future e-BRAINS applications require significantly higher integration densities. Performance, multi-functionality and reliability of such complex heterogeneous systems will be limited mainly by the wiring between the subsystems. Suitable 3D integration technologies create a basis to overcome these drawbacks with the benefit of enabling minimal interconnection lengths. In addition to enabling high integration densities, 3D integration is a very promising cost-effective approach for the realization of heterogeneous systems.Besides the heterogeneous system integration the main criteria of e-BRAINS is the need for miniaturized energy storage/delivery systems, low power co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Printed Optoelectronic Devices from Nanosheet Network Electrochemically-gated Field Effect Transistors' in the context of a Horizon 2020 call.

assistant: **Objectives**

Much research is underway to create a new class of inexpensive electronic devices fabricated by printing combinations of nanomaterial- & functional polymer-inks onto arbitrary substrates, such as everyday plastic film. This will open a route to a wide range of electronic, optoelectronic & electrochemical applications that are impossible using conventional silicon-based manufacturing approaches. For example, it will enable devices that are mechanically deformable (i.e. flexible or stretchable), optically transparent, or even cheap enough to be considered disposable. Innovative features such as these will enable electronic functionality to be integrated into locations where they are currently not feasible. As such, these printed electronics technologies will have applications in many areas of concern for modern society such as public security, healthcare & environmental protection. Here we aim to fabricate aerosol-jet printed ensembles of semiconductor nanosheets (i.e. nanosheet networks) with controlled composition & morphology, then fabricate these into electrochemically-gated field-effect transistors (E-gated FETs). This will enable the study of electronic transport, charge separation & recombination processes that occur within these networks with the view to apply them within cheap, printable photodetector & electroluminescent devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A Streptavidin Microarray Platform for Capturing of Circulating Tumor Cells from the Blood of Cancer Patients', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The main cause of death in cancer patients is not the primary tumor but rather metastasis, which is initiated by the spread of circulating tumor cells (CTCs) in the blood. Therefore, CTCs will become a valuable diagnostic tool, once a reliable, cost-effective method is established. Research in the ongoing ERC Advanced Investigator Grant DISSECT (PI: Klaus Pantel) has revealed clear limitations of existing platforms for the detection of CTCs. The enrichment and identification of CTCs out of a blood sample is still a major challenge, mainly because the ratio between CTCs and blood cells is approximately 1:109. The proposed CAPTURE-CTC project is based on this knowledge and aimed to develop and validate a novel improved platform for CTC detection: Pumping a suspension of blood cells through a microfluidic chip, only labeled CTCs get immobilized on a micro-pattern due to strong biotin-streptavidin interaction. Single cell analysis can be performed after the cells are quantified, optically localized and extracted from the pattern with a micro-capillary. This platform will be validated on cancer patients. The detection of CTCs is a very active field, targeted by several SMEs with approaches in different stages of development and/or clinical application. However, the only FDA-cleared assay for CTC detection is the “CellSearch CTC Test” which will be the benchmark in regard to performance, validity of results and cost per test. The CellSearch system has technical limitations (e.g., EpCAM-negative CTCs are not captured and it is a closed system that allows no easy access to the captured CTCs for subsequent molecular characterization analyses). Our proposed CAPTURE-CTC system will constitute a novel platform that will overcome these important limitations and establish an easy-to-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Basic Mechanism of Neurodegeneration in Transmissible Spongiform Encephalopathies : Role of Amyloidogenic prion protein PrP in glial activation' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The proposed investigations are aimed to find evidence for the following:PrPSc provides a stimulus for glial activation and cytokine production.A-sheet formation and/or aggregation of PrP are important determinants for the pathological properties of PrPSc. The pathological basis for neuronal death in transmissible spongiform encephalopathies (TSE) is unidentified. The pathology is characterized by accumulations of protease- resistant isoforms of the prion protein PrP (PrPSc), neurodegeneration with progressive loss, and vacuolation of neuronal processes. Astrocytosis and microglial activation occur in affected areas of the brain. Direct neurotoxicity of certain PrP peptides has been demonstrated in primary cultures of neuronal cells, but its effect on activation of glial cells is incompletely documented. The effect of activated glia on scrapie-infected neurons is also unknown. A knowledge of the molecular mechanisms responsible for neurodegeneration in TSE would also be informative for understanding other amyloid related conditions such as ageing and Alzheimer' s disease. Therefore, the following hypotheses will be investigated: 1. PrP or part of the molecule is critical in initiating the chain of events leading to neuronal degeneration. 2. Glial activation is an important step in this process. These questions will be approached with in vitro experiments by exposing primary cultures of CNS cells to PrPSc and PrP based peptides with distinct structural properties. The attention will be focused on the effects of exposure to PrP preparations on levels and timing of expression of cytokines and anti-inflammatory mediators in glial cells. For these experiments, primary cultures of mixed astrocyte/microglial constitution, and cultures enriched for astrocytes and microglial cel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Smart optical and ultrasound diagnostics of breast cancer' (SOLUS) targeting Horizon 2020.

assistant: **Abstract**

SOLUS is a trans-disciplinary 54-month project bringing together 9 partners: industries (4), academic and clinical institutions from 5 countries (engineers, physicists and radiologists) representing cutting-edge expertise in their fields, to develop an innovative non-invasive, point-of-care, low-cost, easy-to-operate, multi-modal imaging system (diffuse optics and ultrasounds/shear wave elastography) for high-specificity diagnosis of breast cancer, the most common female cancer in Europe. Mammographic screening is effective in reducing mortality, however the 10-year cumulative false-positive risk is 50-60%, leading to needless additional invasive procedures (e.g. biopsy). The project addresses the unmet clinical need for higher specificity in breast cancer imaging following screening by fully combining photonics with non-photonics techniques, developing and clinically validating innovative and previously unthinkable photonics concepts and components: time-domain small source-detector distance optical tomography, miniaturized picosecond pulsed laser sources, high-dynamic-range time-gated single-photons detectors to achieve unprecedented sensitivity and depth penetration. For the first time, this allows a comprehensive quantitative characterization of breast tissue including composition (water, lipids, collagen), functional blood parameters, morphologic information and mechanical parameters (stiffness). This innovative multi-parametric characterization will significantly improve the specificity of breast screening, with great impact on the quality of life of millions of European women every year, and huge savings for the healthcare systems. The strong involvement of leading industrial players at all levels in the value chain will push the European innovation process and m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Realization and characterization of flexible arrays of fototedectors' (OFLEXFOTODETEC).

assistant: **Concept**

Since the first discovery of conductive polymers made in summer of 1977 by Heeger, MacDiarmid and Shirakawa, a great deal of interest has focused on the developing of a technology based on all organic materials. Conventional plastic materials are, in fact, electrical insulators, but with the discovery of a remarkable class of polymeric semiconductors that can conduct electricity, a new era of plastic science and technology was opened. In this contest, the possibility of integrating different devices onto one substrate using a one production step, opens the way to the realization of large area arrays of photodetectors that can be used as large area radiation sensors for medical, pictures recognition and safety applications. The possibility of constructing the photodetectors on a flexible substrate, gives the possibility of having high resolution detection as the photosensor can conform to the surface of object or sources. The aim of this project is to investigate the feasibility of the realization of arrays of organic photodetectors on flexible substrate .To do that it is proposed both a technological and theoretical analysis of the problem.The first part of the project will be focused on the the use of different materials and configuration to reach high efficiency devices; secondly, the integration of these optical devices in arrays. In case of photodetector arrays, their realization on both polysilicon and organic flexible substrates will be investigated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'CALCIUM CYCLE FOR EFFICIENT AND LOW COST CO2 CAPTURE IN FLUIDIZED BED SYSTEMS' (C3-CAPTURE) under Sixth Framework.

assistant: **Objectives**

Objectives: The project aims on developing a dry CO2 capture system for atmospheric and pressurized fluidized bed boilers. The atmospheric option will be developed towards a pilot plant application. For the pressurized option the project seeks for a proof of principle to determine if the advantages of a pressurized capture system can balance the problems known from existing PFBC systems. The quantifiable objectives are: - Low CO2 capture costs (<20 Euro/t for atmospheric, <12 Euro/t for pressurized sy stems) - Acceptable efficiency penalty for CO2 capture (<= 6% nel). - >90% carbon capture for new power plants and >60% for retrofitted existing plants - A purge gas stream containing >95% CO2 - A solid purge usable for cement production - Sim ultaneous sulphur and CO2 removal with sulphur recovery option Approach: Limestone is a CO2 carrier. The CO2 can be released easily in a conventional calcination process, well known in the cement and lime industry. By integrating a closed carbonation/calc ination loop in the flue gas of a conventional CFB-boiler, the CO2 in the flue gas can be removed. The heat required for calcination is released during carbonation and can be utilised efficiently (high temperature) in the steam cycle of the boiler. Concent rated CO2 can be generated when using oxygen blown calcination. Because the fuel required for supplying heat for calcination is only a fraction of the total fuel requirements, the required oxygen is only about 1/3 of the oxygen required for oxyfuel process es. The work programme: 1.Definition of the technical and economic boundary conditions 2.Selection and improvement of sorbent materials 3.Lab scale and semi-technical scale process development (experimental work) 4.Technical and economic evaluation 5.Des ign of a 1 MWth Pilot pl