RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Smart engineered Bioreceptors for developing BioSensors' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

WHY: Although the impressive advances in the field of biosensing, most efforts are oriented in delivering lower limits of detection, whereas other aspects remain unattended. As consequence, the majority of novel assays for the detection of biomarkers still require: sophisticated equipment, washing intensive, reagent-intensive multi step processes. To effectively overcome the cited limitations and clear the way to the desired point-of-care tests (reagentless, single step, quick response, reusable, user friendly, robust and precise) it is mandatory to engineer the recognition elements (RE).WHAT: The aim of the proposal, SBS, is to develop novel electrochemical biosensors by engineering the RE responsible of detection. I will achieve so by rationally applying mechanisms found in nature; First, I will explore the amazing single-step, reagentless signal transduction naturally occurring biological systems. Next, I will enhance precision of the recognition element (high output upon subtle variations of target concentration) through the insertion of cooperativity. Finally, I will deploy the engineered RE in biosensing approaches.HOW: During the fellowship I will undertake a training program to develop skills and acquire expertise in biophysiscs, molecular biology and electrochemical biosensor. In a first out-going phase I will join Prof. K. Plaxco (UCSB) who is a world-wide expert in biomolecule folding and biophysics, there I will develop the engineered folding based RE. In the subsequent phase I will join Prof. F. Ricci group at University of Rome, Tor Vergata. Prof. Ricci leads a young and dynamic group specialized in the field nanotechnology, DNA engineering and electrochemical biosensors. Within his group I will work in the application of the RE into biosensors. The fellow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Rise of Placental Mammals: Dissecting an Evolutionary Radiation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Mammals are ubiquitous, with over 5000 species across the globe. But how did mammals become so successful? There is vigorous debate among palaeontologists: did mammals explosively diversify after a sudden environmental crisis knocked out dinosaurs at the end of the Cretaceous (~66 million years ago) or rise to dominance more slowly, alongside the dinosaurs? The debate persists because we still know very little about those mammals that flourished during the ~10 million years after the end-Cretaceous extinction (the early Paleogene), as they are largely ignored because their ‘archaic’ anatomy has long confounded palaeontologists. This project will use a wealth of newly discovered fossils and state-of-the-art analytical techniques to finally untangle the evolutionary story of these ~200 critical species. We will comprehensively study the anatomy of ‘archaic’ species using state-of-the-art imaging technology and build a species-level genealogy placing these long-mysterious mammals in the context of their Cretaceous forebears and modern mammals. Cutting-edge quantitative methods for studying evolution, including novel techniques developed here, will be applied to the family tree to date the origin of placental mammals and the major modern groups, determine what effect the end-Cretaceous extinction had on mammalian biodiversity, quantify the tempo and mode of the placental radiation, and explicitly test for potential drivers of mammalian diversification. This will give ground-breaking insight into how major groups become successful over evolutionary time and how biodiversity is affected and reset by dramatic environmental changes, a pressing concern in today’s rapidly changing world.


**Keywords:** palaeontology, macroevolution, evolution, mass extinctions, phylogenetics, ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a FP7 proposal on 'Implantable Organic Nano-Electronics'.

assistant: **Innovation**

The vision of iONE-FP7 is to exploit for the first time flexible organic electronics for the development and testing of Active Multifunctional Implantable Devices (AMIDs) to treat Spinal Cord Injury (SCI). The devices will (a) have long-term stability associated to high biocompatibility and safety, (b) have reduced risk of a host versus graft immune response, (c) mimic the local microenvironment for stem/precursor cell recruitment and differentiation, (d) monitor locally the functionality of the regenerated nerve cells to intervene with loco-regional therapies (e) perform local stimulation with tunable electric fields, (f) deliver locally growth factors, neurotransmitters, and drugs.The use of flexible organic electronics devices (ultra-thin film organic field effect transistor (FET), organic electro-chemical transistor, nanoparticle organic memory FET) will advance the state-of-the-art of implantable devices for SCI from passive to active layouts that will promote nerve regeneration by a combination of local stimuli delivered on demand, will sense inflammation, and will control the immune-inflammatory response.The biomedical impact of the project will be demonstrated in vitro and in vivo. In vitro, the neural therapeutic plasticity induced by the iONE-FP7 device will be evaluated on stem cells, which will be differentiated to neural progenitor cells, and then to neural cells. In vivo, the study of neural plasticity will be transferred to endogeneous stem cells by implanting the iONE-FP7 device into a contusion SCI animal model.iONE-FP7 will acquire the knowledge and the technology required to regenerate the nerve in the niche of the injury.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Visually Impaired Children Kit for Inclusive Education'.

assistant: **Objectives**

Vickie is intended to develop a learning environment for the inclusion of visually impaired students and pupils (VISP) in mainstream education. Vickie will provide services for three categories of end-users:(1) learning utilities for the VISPs themselves, including simple tools like schoolbooks and notebooks, timetables, e-mail,(2) editing tools for the creation of accessible documents, making possible for sighted teachers to create documents that can be printed or read either on screen, tactile or audio device,(3) tools for augmenting standard electronic documents (provided by publishers) in order to make them accessible by the VISPs, intended to professionals working in transcription centres.VICKIE will develop an architecture making possible co-operative work over a network in order to strengthen the community of teachers and VISPs. VICKIE aims at the effective commercialisation of a product helping the visually impaired into the digital age.DESCRIPTION OF WORKThree categories of end-users are considered in VICKIE:the VISPs themselves,their teachers,and professionals bringing VISPs specific support they may need.The needs of these three categories will drive the project. A detailed study of the users' needs will be conducted from the beginning of the project, involving organisations having a wide experience in the field and a national audience, in 3 countries.This study will particularly focus on assistive technologies and survey the emerging technology in distance and co-operative learning. Technical development will be split into:- a software architecture running a network of learning workstations. It will be open as to allow the upgrading of services through the VICKIE network. New services will be easily added.- Services to end-users. Basics should be: schoolbook
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The role of insulin in the development of nociceptive dysfunctions in impaired glucose tolerance, the condition preceding type 2 diabetes' in the context of a Sixth Framework call.

assistant: **Objectives**

Unpleasant sensory experiences and burning pain are frequent complications of diabetes mellitus (DM). Degenerative changes of primary sensory neurones (PSNs) caused by metabolic alterations and absence of insulin-mediated neurotrophic effects contribute to the development of these symptoms. The manifestation of type 2 DM is often preceded by impairment of glucose utilisation and a compensatory hyperinsulinaemia. Despite the lack of metabolic disorders dysfunctions of the thermo-nociception are still present during this period indicating that hyperinsulinaemia might influence the activity of heat sensitive PSNs. Recently we found that insulin activate a subpopulation of PSNs expressing the heat transducer molecule Transient Receptor Potential Vanilloid 1 (T RPV1) ion channel. Therefore we intend to study the long term effects of hyperinsulinaemia on the neurochemical phenotype and sensory functions of PSNs. Effects of hyperinsulinaemia will be studied on Zucker diabetic fatty (ZDF) rats the animal model of ty pe 2 DM.Expression of TRPV1 and other neurochemical markers of nociceptive neurones will be investigated by morphological and biochemical methods on PSN cultures incubated in the presence of insulin and in sensory ganglia of ZDF rats. Functional alterations in primary nociceptors chronically exposed to insulin will be assessed by measurement of neuronal responses evoked by noxious chemical and thermal stimuli. The sensory afferent- and the vasoregulatory efferent functions of cutaneous and visceral nociceptors as well as the development of the inflammatory heat hyperalgesia will be investigated in ZDF rats using behavioural tests and in vivo measurements of sensory nerve-mediated vascular reactions. These experiments will provide new information on the role of hyper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Approximation of Turkish legal provisions in the field of consumer contracts to EU Law' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The subject of the present research project will be the Approximation of Turkish Legislation in the Field of Consumer Contracts to Community Law". Since February 1995 Turkey has been making every effort to approximate its legislation to EC law as far as possible. In order to implement the directives on consumer protection, a skeleton consumer protection law was enacted in Turkey in September 1995. Though this law is an important first step in approximating Turkish legislation to the provisions of Community law, it is not sufficient for achieving a full-fledged approximation to the standards of EC law. Therefore, the subject of this project is to investigate which further steps will be required in order to achieve a full-fledged approximation.The central point of this project will be consumer contract law. The starting points of the investigation will be sources of law and legal cognition, which will lead to the current state of Community law in this branch of law. Working from this basis, the impact of the new consumer protection law on Turkish contractual law will be investigated and also how its provisions can be better harmonized with the standards of Community law. The secondary object of this research project is the preparation of Turkish legislation for the future unification of the European law of contracts or material civil law respectively.The study is to support the strategic goal, which the Commission set in its notification on the European law of contracts, namely the goal of harmonizing material civil law. In this connection the reform efforts in Turkey in the framework of the reform of the law of obligations are certainly an important project in order to bring the Turkish law of obligations in a position where it can keep up with modern works of law in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Green Locally Unwanted Land Uses' (GREENLULUS) under Horizon 2020.

assistant: **Objectives**

This project examines the role played by the restoration and creation of environmental amenities in the redistribution of urban quality of life. Since no large-scale study has been conducted to measure if greener cities are less racially and socially equitable, I will analyze whether greening projects tend to increase environmental inequalities in 40 cities in the US and Europe and under which conditions such projects can address equity concerns. First, the study will a) develop a new method (an index) to quantify the racial and social impact of greening projects and to compare cities’ performance with each other; b) provide a spatial and quantitative analysis of neighborhood demographic, real estate, and environmental data; and c) apply the index methodology on a unique ranking of cities. Second, my research will analyze the response of private investors to the greening projects and identify the impact of new development projects proposed, approved, and implemented during or upon the completion of greening projects on the neighborhood socio-demographic characteristics. I will assess the extent to which development projects seem to encourage and/or accelerate gentrification, as such projects have been shown to be signs of residents’ exclusion. Additionally, this study will qualitatively analyze cases of community mobilization developed in response to new environmental amenities, through fieldwork in 16 critical neighborhoods (one neighborhood case per city) among the 40 cities. Last, this study will use qualitative methods to analyze the policies and measures that municipalities develop to address exclusion in “greening” neighborhoods. This groundbreaking longitudinal, systematic, in-depth, and large-scale project in the field of environmental justice will lead to a par
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Conditions of success for R&T Open options through a Platform of communications and for Expressing Recommendation Actions to Team-up Europe and U.S'.

assistant: **Objectives**

COOPERATEUS is a European Project within the Framework Programme 7 (Research / Aeronautics and Air Transport) aiming at establishing an initial framework, data base and network, in order to facilitate and enhance the cooperation in R&T activities between the two largest world players in aeronautics, i.e. the USA and Europe. It will introduce a more structured dialogue to identify the similarities in the respective research agendas / road maps. It will be used to create a better mutual understanding, thus permitting toBuild up ad-hoc EU-US R&T cooperation areas of mutual benefitpropose win-win R&T roadmaps / cooperations (ex: volcanic ashes)Have a mutual understanding of administrative mechanisms: clarify the principles governing such EU-US R&T cooperation, respective funding mechanisms, IPRs, …etc…and the main barriers to that cooperation and suggest ways to overcome all the problems.COOPERATEUS project will indicate the areas where the cooperation topics are mutually favored assuring a good reciprocity between the parties.More over, COOPERATEUS is in the logic of the EU-US memorandum of cooperation (MoC) presently under preparation.It will not interfere with the various EU-US R&T cooperative activities already undertaken, but might nonetheless provide rules and reference that could be beneficial to all.Finally the project will provide common R&T road maps for cooperation to be introduced in future calls for proposals within Framework programmes of the European Commission and mechanisms in the US.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Reaching the public and promoting research in Cyprus - A night to celebrate'.

assistant: **Objectives**

The CELEBRATE" proposal is being submitted following the launch by the European Commission of a call for proposals regarding the organisation of "Researchers' Nights" across Europe on 22 September 2006. The proposed actions are intended to bring closer to gather the research community and the general public of Cyprus.The main aim of the proposed events will be to promote the research landscape of Cyprus and put the spotlight on the people and organisations involved in it. In this way we aim to make research "real" and "approachable" by presenting real-life researchers and showing that they are ordinary people with ordinary habits and interests.Our proposed events will also aim at:- Reaching the various age groups and categories of the population and giving them a taste of research in Cyprus, Europe and across the world.- Raising the younger generations' interest in science and research thus helping to create a much needed "research culture".- Raising the general public's awareness regarding research, its history and major scientific achievements from across the world that have positively affected our everyday lives.- Giving a clear message to politicians that investing in research will help boost the economy and increase Europe's competitiveness.Despite the rise in the Government's investment in research over the past few years, that has seen the Research and Development (R&D) expenditure rise from 0,18% in 1992 to almost 0,5% of the GDP in 2005, Cyprus lacks behind its European partners not only in research activities and infrastructure but most importantly in "research culture".Thus, the opportunity to organise raising awareness events, with the collaboration of most of the island's Academic and Research Institutions, will hopefully be the beginning of what promises t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Injection lasing in organic thin films' (ILO), addressing dissemination and exploitation.

assistant: **Impact**

Organic semiconductor devices offer the advantages of easy processing, low cost and flexibility. Light-emitting diodes (OLED), thin-film transistors (OTFT) and solar cells (OSC) have been shown so far. The demonstration of the organic injection laser has been recently withdrawn. It is the purpose of this project to explore injection lasing in organic semiconductors at the solid state. The main difficulty for realizing an organic injection laser is that the device is to support the required high current density. We tackle this problem from two sides. We maximize the current-carrying capability of the device by using charge transport crystalline organic material in a TFT configuration. Simultaneously, efforts are done to limit the required current density, by using a highly efficient energy transfer light emitting system in which the energy acceptor and emitting site is a coordinated metal complex.OBJECTIVESThe main objective of the project is to explore the effect of organic injection lasing that is based on organic semiconductors in solid state. On the way to realizing this objective, several results and milestones of the proposal form sub-objectives, that are extremely useful in themselves:1. The synthesis of coordinated metal complexes with high quantum yield and low lasing threshold, where the metal can either be a rare earth or a transition metal. Such complexes are valued for efficient organic electroluminescence;2. The realization of efficient OLEDs with the synthesized new coordinated metal complexes.3. Achieve effective ambipolar conduction in organic crystalline solid. This is useful for organic transistors, since ambipolar conduction is a cornerstone to implement complementary logic OTFT circuits.DESCRIPTION OF WORKOur goal is to explore the effect of organic