RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The role of recombination in evolution and epidemiology of bacterial pathogen Streptococcus pneumoniae' to be submitted under Seventh Framework.

assistant: **Abstract**

The aim of this project is to improve our understanding of the role of recombination (uptake and incorporation of foreign DNA) for the evolution and epidemiology of the major human bacterial pathogen Streptococcus pneumoniae, also known as the pneumococcus. There is an increasing appreciation of the public health significance of recombination in S. pneumoniae, where recombination has enabled major drug-resistant lineages to rapidly evade new conjugate vaccines. Here, I propose to investigate the role of different mechanisms of recombination in the context of (a) coevolution of the pathogen with the human immune system, (b) generation of novel antigenic diversity at the capsular locus, and (c) adaptation to clinical treatment by generation of novel bacterial lineages carrying multi-drug resistant genes and vaccine “escape” antigens. To do so, I will use an interdisciplinary approach of evolutionary microbiology, immunology, and epidemiology of infectious diseases. First, I will employ a generic evolutionary-epidemiological modelling approach to understand the population dynamic of recombination. Second, I will analyse newly available pneumococcal full-genome sequences to examine the link between recombination, immunity, vaccine, and drug-resistance in pneumococcus. The benefit of this research will be threefold. First, a better understanding of the role of recombination in coevolution with the human populations would be of benefit to the field of bacterial evolution and microbiology in general. Second, the approach outlined here can be applied to study recombination in other recombinogenic bacterial pathogens, like Neisseria meningitidis, Salmonella enterica or Helicobacter pylori. Finally, gaining further insight into the predicted long-term response against the current
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Environmental regulation, globalisation of production and technological change.'.

assistant: **Objectives**

To analyze the impact of environmental regulation within the European Union on the competitive position of industry and on trade, foreign investment and employment, particularly in relation to newly industrialising and developing countries where such regulation may be less stringent.OBJECTIVES: To analyze the impact of environmental regulation within the European Union on the competitive position of industry and on trade, foreign investment and employment, particularly in relation to newly industrialising and developing countries where such regulation may be less stringent. DESCRIPTION: The research focuses on the following issues: i) The change in the competitive position of a dozen highly polluting industries in the EU with significant environmental impacts. Associated trends in international trade and investment are analyzed. Technological developments in response to environmental regulation and firm strategies are also investigated. ii) A more detailed study of three polluting industries which are significant in trade terms, with particular emphasis on the nature of technological change within each branch, the diffusion of clean technologies" and the strategies of individual firms. iii) Country level studies are undertaken in the case of a number of newly industrialising and less developed countries which are significant exporters to the EU of relevant "pollution intensive" products. The environmental regulation in the countries selected, the nature of the technology utilised and the competitiveness of production vis-a-vis the EU are analyzed. The research concludes with a synthesis of the various case studies, to highlight the determinants of the impact of environmental regulation on technology and competitiveness, and the ways in which these are reflected in the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Further development of particle and nuclear detectors based on superconducting tunnel junctions' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The Superconducting Tunnel Junctions offer several unique advantages fo the detection of nuclear particles. One of these is the possibility to measure the particle energy with high resolution. Basically the idea is that particle interactions break Cooper pairs and excite quasi-particles above the superconducting energy gap. These can be collected with a superconducting tunnel junction. Because of the small value of the energy gap (10-3 times that of semiconductors), the number of excited charges is roughly 10-3 times larger, resulting in better energy resolution.  The aims of the proposed research work are to extend these technologica developments to the realisation and characterization of new special detector configurations, suitable for use with both the quasi- particle trapping mechanism, and with thermal coupling between the detector and the substrate. Based on the extensive experience in the physics of the Josephson effect of the Naples group, attention will be devoted also to the geometrical effects in the performance of STJ detectors, as well as to investigations into the possibility of using the Josephson effect as a fast detection mechanism for discrimination experiments.  My goals are to integrate my Training in performing experiments on STJs under exposure to nuclear radiations obtained at Oxford University, under HCM contracts (EC nos.CT920195 and CT941220), with the work programme of the Naples group, as well as to achieve a deeper knowledge and a wider competence in the field of superconductivity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Foot Transport for a Smart Mobility'.

assistant: **Innovation**

Foot Analytics is a pioneer in the field of offline commercial analytics based on passenger’s smartphone identification, tracking (WiFi tracking technology) and connection, through a powerful algorithm of intelligence behaviour analysis. It is a big data technology (based on the capture and processing of millions of data, in real time) oriented to the real world  comparable in terms of capabilities to what the homologous technologies of the online world do (count visits, length of a visit, etc..). Taking advantage of the growing Smart Transport market, we decided to apply our technology to the Transpor segment and launch a “plug&play” solution, that offers a reliable and continuous passengers behaviour analysis on any public means of transport. Foot Transport aims to collect and provide quantitative and qualitative data regarding passenger’s mobility  to optimize the transport system, offering a 360º solution not available yet in the market. Thanks to our solution, transport operators and smart cities will be able to analyse passengers profiles and understand how they use public transport to improve the Urban Mobility Planning, optimize the fleet usage, and reduce operational costs while offering a higher quality service for citizens. The global Smart Transportation market is to reach 235.13€ Bn by 2022with UK, France and Denmark are leading the growth in Europe. We will enter the market through Spain, UK and France, expecting a ROI of 1,89 by the 5th year of commercialization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sustainable development in a diverse world' to be submitted under Sixth Framework.

assistant: **Abstract**

The primary objective of SUS.DIV is to integrate European research capabilities across disciplines and countries in order to provide European society and polity with the instruments and tools for managing cultural diversity as a key element of a new stra tegy for sustainable development. This primary objective can be broken down into the following subsidiary objectives: *to provide a better understanding of cultural assets and how their diversity contributes to human welfare and knowledge creation; *to p rovide a better understanding of the dynamics of cultural diversity in Europe and the world in relation to the processes of globalisation, European integration and enlargement; *to explore cultural dialogue as a key mechanism through which cultural divers ity can lead to knowledge creation and social capital *to promote lasting co-operation and integration, bringing about a new way of carrying out research in Europe. *to serve the wider European research, policy and business community and the public at la rge, by promoting new excellence, preparing the next generation of researchers and creating enduring physical and virtual spaces of interactions among researchers and stakeholders. The Joint Programme of Activities is constructed around four Research Th eme and three Structuring Action Lines. 'Research Theme 1. Understanding diversity. 'Research Theme 2. Global vs. local: cultural diversity in the globalisation era.'Research Theme 3: Diversity knowledge creation and creativity'Research Theme 4: Cultural dialogue: unfolding diversity. 'Structuring Action Line 1: Indicators and data 'Structuring Action Line 2: Coordinating and integrating training activities 'Structuring action Line 3: the Forum Initiative'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrated biomolecular methods to control mosquito-borne diseases' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Mosquitoes transmit some of the world's most serious diseases. The most important disease vectors are members of the subfamilies Anophelinae and Culicinae. Anopheles mosquitoes transmit malaria, filarial parasites , and a few arboviruses. There are 30 genera in the Culicidae subfamily, but the medically important mosquitoes are Culex, Aedes, Mansonia, and Annigeres (Culex would be important in Europe for West Nile Disease and Avian malaria), while (Aedes would be more important in Tropical countries). Over the last 45 years, the use of chemical pesticides such as dichlorodiphe-nyltrichloroethane (DDT), gammaxane, malathion, and chlordane has been the method of choice for mosquito control, and the antimalarial drugs chloroquine and the affordable pyrimethamine-sulfadoxine combination have proved successful in lowering morbidity and mortality. In addition, the emergence of pesticide and drug resistant mosquitoes, coupled with a clearer appreciation of the long-term detrimental effects of powerful chemicals to non pest insects and concern about accumulation of pesticides in the food chain and environment, has high lighted the need to quickly develop an alternative. A promising alternative is biological control. So, this project would focus on non-chemical methods of control mosquitoes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'University education as a driver for sustainability transitions'.

assistant: **Concept**

UNI4ST aims to create empirically grounded knowledge on how university education can be designed and performed in such a way that it becomes a fruitful driver for Sustainability Transitions (STs). Learning is considered a vital means of realising STs, but an empirical knowledge base that offers adequate guidance for the improvement of teaching and learning practices is lacking in the available literature. We address this research gap by developing a tailored analytical toolbox (methods, research instruments) for empirical investigations, inspired by pragmatist didactic research. Next, we apply the analytical tools to 3 pilot case studies of university education practices where academics, students and societal stakeholders jointly address sustainability challenges in the local community. This results in knowledge of how the design and performance of teaching and learning practices produce outcomes that promote STs. Furthermore, it allows to develop a much-needed, systematic research agenda by formulating hypotheses for future investigations. Through open access journal articles, academic conferences, a handbook, lectures, seminars, an opinion piece, workshops, a self-assessment manual for university teachers and a web-database with quality-assured practices, the results of UNI4ST are communicated and disseminated to varied audiences. Applications for follow-up research projects and a business plan facilitate the exploitation of the results. Through creating state-of-the-art knowledge and the reinforcement of methodological, management, communication and entrepreneurial skills, the experienced researcher will strengthen her international profile, visibility and network in the fields of sustainability transition studies and sustainability education research and become an i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'FrOm RupturE procesS to Earthquake Early warnING'.

assistant: **Innovation**

FORESEEING means “FrOm RupturE procesS to Earthquake Early warnING” and is a groundbreaking research project halfway between the investigation of the earthquake generation processes and the implementation of methods for real-time risk mitigation actions. Incredible progress in earthquake source characterization and modelling has been achieved in the last decades. However, the mechanism of nucleation, radiation and arrest of seismic fractures is still poorly understood and with that, the fundamental issue of seismology is still unsolved: “How do earthquakes begin and what does control their final size?” Within FORESEEING, I want to get to the bottom of the earthquake nucleation with all possible means. I want to solve the unsolved issue of how earthquakes start and understand the physical processes of their generation. Once this issue is understood, I want my research outcomes to become a concrete support for the community and be implemented into Earthquake Early Warning systems, for the prompt activation of emergency actions that can save lives, reduce damage, improve resilience. This will be achieved through an interdisciplinary research approach looking at the rupture process from different points of view. Real earthquake data will be used to find out evidence of the nucleation phase of seismic ruptures and to understand the relationship between the observed features of the initial recorded signals and the following evolution of the seismic ruptures. Laboratory experiments will allow to deeply understand which parameters may influence the rupture development and how they are involved in the process. Digital twins will give the chance to explore in great details the fracture processes during crustal earthquakes and investigate faulting mechanism in realistic conditions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Structural basis of selective autophagy mediated by cargo receptors'.

assistant: **Concept**

Autophagy is a bulk cellular degradation pathway in which double-membrane vesicles engulfe large and long-lived cytoplasmic structures and target them to lysosomal compartments. Employing an integrated structural biology approach using single-particle cryo-EM and X-ray crystallography, this proposal aims to elucidate the structural details by which the autophagosomal recognition machinery identifies and assembles its cargo for targeting to autophagosomes. It has recently become apparent that selective autophagy requires specific receptors that recognize and recruit defined cargo into molecular assemblies and target them for autophagosomal degradation. Dysfunction of this process is implicated in a number of important human pathologies, such as cancer, neurodegeneration and myopathies. A precise understanding of the molecular mechanisms underlying selective autophagy requires the structural characterization of the molecular complexes involved in this process.  First, the ultrastructural architecture of homo-oligomeric receptor assemblies will be established. Second, the structural organization of cargo-receptor complexes will be defined for a hetero-oligomeric, mechanosensitive model complex involved in muscle homeostasis using a combination of cryo-EM and X-ray crystallography. Third, oligomeric changes of cargo-receptor assemblies will be related to cellular function. In its aim to establish a multi-resolution view on the molecular principles of selective autophagy, this proposal has the potential to fundamentally advance our current understanding of this important degradation pathway.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Developmental Biology' under Fifth Framework.

assistant: **Concept**

Developmental Biology has emerged as a major new discipline as a result of the convergence between classical embryology, genetics and modern molecular and cellular biology. In addition to more specialist publications, such as Development, which have acquired considerable impact over the last decade or so, a rapid glance at front line journals such as Nature. Cell, Science, immediately indicates the current importance of advances in this field. The series of Euroconferences on Developmental Biology has accompanied and contributed to this expansion and provided an invaluable forum for the exchange of information and ideas between established Developmental Biologists and newcomers interested in research in this area.As in previous meetings the 2002 Conference will present some of the most topical and important aspects of the field. Because of the Potential breadth of subject matter, it is important to avoid too much dispersion, and this meeting will focus on tissue specification and patterning with the underlying universal themes of signalling systems and target regulator genes, the activation of which leads to the restriction of cell fate during embryogenesis. Closely related to this, is the topic of stem cells, which is currently exciting major interest, because of potential biomedical (and ethical) implications. Indeed the proposed subject of the meeting is designed to promote understanding of this issue. Different tissue types will be discussed in different sessions. In addition there will be sessions devoted to signalling systems and to stem cells per se.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2001-00045-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'MANAGING RESILIENT NEXUS SYSTEMS THROUGH PARTICIPATORY SYSTEMS DYNAMICS MODELLING' under Horizon 2020.

assistant: **Concept**

REXUS ambitious goal is to bring transformative change in the way our societies approach the Water Food Energy Climate Nexus. The project argues that this is possible only through the activation of inclusive nexus partnerships, the Learning & Action Alliances (LAAs). The objective is for the pilot case Alliances in Europe and Latin America to develop shared visions and adaptive Nexus Management Strategies that will meet the Nexus sectoral objectives as well as broader criteria, such as habitat protection.In this context, LAAs will (a) co-produce new knowledge regarding Nexus interactions to inform the development of System Dynamics Models at suitable spatial and temporal scales and (b) explore multiple co-developed scenarios of demographic change, climate change, socio-environmental, economic incentivization and regulatory policies. Thus, SDM development is the means to (i) develop stakeholder platforms of trust, (ii) test the efficacy of integrated cross-sectoral policies, and (iii) build legitimacy for evidence-based decisions towards sustainable transitions. SDMs will inform climate risks assessments for combined-resource-management strategies by capturing the cascading effects among Nexus domains.The pilot cases will be the test-beds for the integration of methods, such as thematic biophysical modelling using Earth Observation, environmental cost valuations, natural capital and carbon accounting to explore case-specific challenges (including greening the CAP). In response to these challenges, Ecosystem-based Adaptation measures will be planned for these regional and transboundary systems.  On a policy level, for the first time, REXUS will explore the opportunity to link Climate Adaptation (i.e. the Paris Agreement framework) to Nexus management as a means to push fo