RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Forcing in Contemporary Philosophy of Set Theory' (2014-2020).

assistant: **Concept**

Forcing is one of the defining techniques of modern set theory. As of late its extensive and deep mathematical results and related foundational questions gained wider attention in the international debate in the philosophy of mathematics. This can be witnessed by the recent development of different research programs in the philosophy of set theory like the Multiverse or Hyperuniverse Program and the formation of new platforms for discussion like the newly founded Set Theoretic Pluralism network.  This project aims to provide a philosophical and mathematical contribution to the ongoing debate by delivering a systematic study of forcing and its philosophical implications. It starts from the new observation that not only the results of forcing but also the way these results are obtained is of vital importance for the philosophical implications of the mathematical work. Our claim is that the method of forcing is not philosophically neutral; i.e. the different ways forcing is used by set theorists is one of the differentiating factors responsible for the philosophical conclusions drawn in the recent research programs. In the first part of the project we will systematically examine the forcing technique, its mathematical uses and the influence forcing has on philosophical debates such as the multiverse versus universe view and ultimately the question of the search for new axioms. We will investigate how the different uses of forcing inform (or even determine) the philosophical upshot of the set-theoretical programs under consideration. Our aim is to shed new light on the ongoing debate. The second part is dedicated to introducing new types of forcing (class-forcing, forcing over non-ZFC models) into the current philosophical debate in order to strengthen our case that the use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Improved physiological, immunological and molecular tools for the recovery and identification of emerging campylobacteriaceae in the food and water chain' in the context of a Fifth Framework call.

assistant: **Objectives**

This project involves leading laboratories from the EU, USA and South Africa forth isolation and immunological and molecular identification of emergingcampylobacteriaceae in-patient and animal faeces and the food and water chain. The work will involve) Sample release and resuscitation techniques for the quantitative isolation of fastidious and sub-lethally damaged species) Rapid antibody and molecular techniques for detection of Campylobacteriaceae3) Typing techniques including antibody-latex, biochemical tests and genomic) National surveys to characterise prevalence of the emerging species
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Advanced Interactive Materials by Design'.

assistant: **Concept**

Urgent needs for better production technologies arise from current development of new pharmaceutical products like fermantation-based antibodies, recombinant proteins or monoclonal antibodies (MABs). AIMs' goal is integrated design of a new class of interactive materials for the use in the pharmaceutical, chemical and bioindustries as well as development of novel materials composed of functional elements (ligands) interacting with target molecules and support structures for separation applications. The radical innovation in MAB production will be an increase in capacity by a factor of 10 to 50 and a decrease in costs of goods by a factor of 10 to 100. The RTD activities will be grouped into 5 sub-projects: Processing, Functionalisation, Parameter Design, Utilisation of Materials and their Applications to Processes.A detailed process analysis of existing selective materials for MAB separations and material performance in existing applications will be done in the 1st of three project cycles. This will help to gain quantitative benchmarks and parameters for further development of a design method for selective materials with regard to applications. The 2nd cycle will achieve a paradigm shift from product-based empirical material testing to a material design method based on molecular and process performance prediction knowledge.RTD activities in various disciplines will be combined with training, result dissemination and exploitation. AIMs will supply the methodology for an outstanding performance and flexibility of material producers, process suppliers and process operators. Pharmaceutical products being currently developed will generate a potential market for a new class of interactive materials that can be tailored to the customers' applications in the process industries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Understanding Non-CO2 Impact for deCarbonized aviation' (UNIC).

assistant: **Innovation**

The UNIC proposal, under the ""Accelerating climate neutral aviation, minimizing non-CO2 emissions"" call, will enhance scientific understanding and mitigate the impact of non-CO2 aviation emissions which emminate from both combustor and oil lubrication vent. UNIC’s objectives are to improve non-CO2 emission measurements, including nitrogen oxides and volatile and non-volatile particulate matter,  across all flight phases. This will improve the understanding of the impact of alternative fuels (SAF and H2) on non-CO2 aged emissions and refine aerosol-cloud interaction models whilst providing robust data to support future aviation policy decisions.To achieve these objectives, UNIC will develop and enhance novel technologies including a cold oxidation flow reactor and an integrated on-board sensor for real-time CO2 and non-CO2 emission quantification across the entire flight envelope, including cruise. UNIC will conduct extensive laboratory, combustor, engine and flight tests using both conventional and alternative fuels. These extensive tests will go beyond certification testing to provide a comprehensive assessment of pollutantes that impact climate. They will include particle size distributions down to 1 nm , gas- and particle-phase chemical composition, charged particle/ion concentration and ice nucleation potential of emissions, including those of lubrication oil. The project will leverage advanced modelling techniques to simulate the interactions of emissions with clouds to improve assessment of their radiative forcing impact more accurately.UNIC aligns with the Horizon work programme by addressing urgent needs in aviation emission science and regulation, providing data that supports the development of effective emission reduction strategies. The proposal's relevance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Lifespan Development of Typical and Atypical Multisensory Perception' (MULTISENSE).

assistant: **Concept**

Daily life confronts us with information across multiple senses in parallel and we must somehow unite these sensations into a coherent interpretation of the world. MULTISENSE will explain how the human brain comes to develop this complex ability, and how certain genetically ‘pre-marked’ brains can come to experience multisensory integration in remarkable ways. Implicit associations across the senses can have a profound and sometimes surprising effect on our experiences (eg, the  taste of food can be altered simply by changing its colour, its shape, or even its name). People with the neurological condition synaesthesia have cross-sensory interactions to an extreme degree (eg, they might experience tastes as colourful moving shapes in the visual field). Synaesthesia can give profound insights into normal perception because all people experience crossed sensations to an implicit degree, and often in ways that mimic synaesthetes (eg, rougher textures tend to be ‘seen’ as darker colours by synaesthetes, and are also paired to darker colours by nonsynaesthetes in sensory matching tasks). In this ambitious proposal I will examine the life-span development of multisensory integration in both synaesthetes and nonsynaesthetes, considering changes that occur throughout childhood, non-elderly adulthood, and older age. My project will unfold over 48 months across 4 inter-related Work Programmes, in which I will develop a state-of-the-art assessment tool to identify child synaesthetes, and use cognitive tests and experimental techniques to evaluate multisensory functions in synaesthetes and nonsynaesthetes across the lifespan. My questions stand at the frontier of our scientific understanding, and will develop an embryonic field of childhood synaesthesia research, and forge a wholly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Decoding the Cancer Glycoproteome Driven Immune Response' (GlyCANswer) under Horizon 2020.

assistant: **Objectives**

Cancer continues to be the most formidable challenge in modern medicine and the second leading cause of deaths worldwide. However, in recent years, the treatment of unresectable cancer has undergone a paradigm shift with the advent of immunotherapy. Yet, despite the great progress in the field, the majority of cancer patients still do not respond to any of the available immunotherapeutics and no reliable biomarker exists to predict those patients that would benefit from it.In order to facilitate the development of new strategies for immunotherapy, and to identify improved predictive biomarkers for treatment response, the GlyCANswer project envisions to elucidate how the cancer glycoproteome dictates the immune response. The GlyCANswer project aims to unravel the interplay between the cancer cell glycoproteome and immune recognition in the two most frequent malignancies worldwide, namely lung and breast cancer. By using a combination of cutting-edge glycoproteomics, glycomics and immune profiling approaches in innovative mouse models and cell culture systems, the GlyCANswer project will 1) map the immunomodulatory glycosylation of cancer cells 2) explore the detailed mechanisms of glycan-mediated immune regulation 3) identify new biomarkers and provide new therapeutic targets for immune therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Roles of SHP2 and other protein tyrosine phosphatases in metastatic breast cancer' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Breast cancer (BC) ranks second among cancer deaths in women. Each year, this disease is diagnosed in over one million women worldwide. Although progress has been made, we still do not understand the biology of BC at a level that would explain why certain patients react well to therapy, whereas for others the disease is recurrent, with an inexorable downhill course. This proposal focuses on the role of SHP2 and other protein tyrosine phosphatase (PTP) in BC metastasis and comprises three parallel approaches. The first aim is to address the roles of SHP2 in metastatic spread. The second assesses the merits of SHP2 as a therapeutic target in established BC metastases and the third will screen for other PTPs involved in metastatic BC. Virtually all cell signaling pathways are modulated by reversible protein tyrosine phosphorylation, which is regulated by two classes of enzymes, the protein tyrosine kinases (PTKs) and PTPs. Whereas the involvement of specific PTKs in BC has been well studied, the functions of specific PTPs in this disease are only now beginning to be elucidated. It has been discovered recently that SHP2 plays a fundamental role in tumor maintenance and progression in HER2-positive and triple-negative BCs, two subtypes associated with a poor prognosis. Importantly, SHP2 knockdown in established breast tumors blocked growth and reduced metastases. How does SHP2 knockdown in primary tumors reduce metastases? Can SHP2 inhibition in established metastases block their growth? Are other PTPs important for breast cancer metastases? To answer these questions, an intravital multiphoton microscope has been made for imaging fluorescently labeled metastatic BC cells expressing or lacking SHP2. These studies use state-of-the-art ex vivo and in vivo approaches to address
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Terahertz wireless information systems and technologies'.

assistant: **Objectives**

This project aims to develop a proof-of-concept prototype of a wireless communication link based on ultra-high bit rate serial THz pulses. THz transmitters are known to be able to produce sub-picosecond pulses with frequency bandwidths in excess of several THz. In principle, this makes THz pulses able to carry Tbit/s data. This project will utilise these features of THz pulses and exploit them by amplitude modulating the THz pulses and stacking them closely together in time, thus creating a serial time-multiplexed THz data stream. This will be achieved by triggering THz pulse emission with an optical pulsed data signal. Optical serial binary data signals have been demonstrated to reach a record bit rate of 1.28 Tbit/s (within the applicant’s ERC project, SOCRATES), and applying these to THz transmitters with their inherent THz bandwidth, leads to the possibility of creating simple binary amplitude modulated baseband THz wireless signals at data rates of several 100s Gbit/s possibly approaching 1 Tbit/s. This is well beyond the currently commercialized 2.5 Gbit/s E-band (70/80 GHz) wireless technologies in microwave telecommunication backhaul, and also enables higher bit rate links than the so-called next generation wireless communication systems, which are mainly operating within sub-THz narrow-band frequency windows (200-300 GHz and 600-700 GHz), based on carrier modulation. The THz frequency band is expected to play a significant role in future generations of wireless communication technology both due to the large unallocated frequency ranges and due to the huge available capacity when using THz waves for baseband data communication. This invention could find use for 4G-LTE small cell backhaul, ultra-high capacity wireless video transfer (e.g. of live sports events),
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project '2D Trifunctional Catalysts for Electrochemical Energy Conversion and Storage' (2DTriCat4Energy), addressing dissemination and exploitation.

assistant: **Impact**

The World is currently in a state of an energy and climate crisis. The World’s fossil fuel reserves are predicted to be depleted in the next century. Due to this and the increase in global warming, EU policies have called for the decrease use of carbon-based fossil fuels and the development of alternative energy resources. Hence, it is of paramount importance to conduct research into alternative energy conversion and storage technologies now. Electrolytic water splitting is an attractive process for producing clean hydrogen which can be used in a fuel cell to make electricity. The electrochemical energy needed for water splitting and fuel cells could be generated by materials that can hold efficient charge in the electrochemical double layer or in Faradaic regions e.g. supercapacitor materials. Unfortunately, these technologies (electrolysers, fuel cells and supercapacitors) are still under major research as the ‘state-of-the-art’ catalysts currently used are uneconomical. The development and rational design of new, cheap and active electrodes as tri-functional catalysts for these three alternative energy technologies is one avenue to explore to reach the goals set out by the various EU polices. 2D Transition Metal Oxide (TMO) materials may be the answer to this problem, as when compared to their bulk counterparts, 2D materials are more conductive and exhibit interesting properties. Currently, in the literature there are no trifunctional catalysts for the aforementioned alternative energy applications based on 2D TMO materials (source: Scopus, terms: 2D TMO materials/water splitting/ fuel cells/ supercapacitors). Hence this fellowship will investigate just that.The proposed multifunctional energy storage and conversion catalysts, in this fellowship, will be a first in t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Treatment of fly ash for sound material utilisation'.

assistant: **Innovation**

The research project consists of following tasks:  1) Analysis of the current literature (VUB-CTW):  -on volatilisation and condensation of heavy metals;  -on methods to characterize fly ash particles.  Carrying out computer based thermodynamic studies (VUB).  2) Comparison of different thermal separation techniques for heavy metals. Making of kinetic studies:  -chloridising volatilisation of fly ash (MHW-TUC);  -equilibrium experiments, real and synthetic ashes (MHW-TUC); -kinetic investigations (MHW-TUC);  -laboratory experiments using pyrohydrolysis (TNO);  -segregation technique (CTW);  -reductive evaporation (CTW).  3) Carrying out pyrohydrolysis experiments in fluidized bed (TNO, CTRV).  4) Carrying out evaporation/segregation experiments on small pilot scale (CTW).  5) Design of a pilot plant (CTRV).  6) Investigation on heavy metals condensation, especially on fly ash carrying out experiments on sequential condensation (VUB).  7) Investigation on processing and utilisation of metal condensate (MHW-TUC).  8) Investigation on assessment and utilisation of mineral product: -utilisation as a civil construction material (CTW);  -investigation on ecological properties (TNO).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Analysis of Transferrin Conformational changes that Impact Virulence and Evolution' under Horizon Europe.

assistant: **Concept**

Structural dynamics define the transition from one protein state to another and are modulated by interactions with partners-ligands and/or chemical modifications. They are important to control protein biological activity, govern protein evolution and their alteration can lead to diseases or death. The long-term objective of ATRACTIVE is to understand protein structural dynamics, their regulation and how such dynamics diversify a conserved structural core to evolve in computing distinct functions. For this, we will focus on human serum transferrin (hTF), which shares an ancient and conserved bilobed structural core composed of two domains from the type-II periplasmic binding protein domain family. This core is fundamental for maintaining iron-homeostasis in human cells conferring nutritional immunity. The same core is harbored by proteins ubiquitous throughout the tree of life that diversified yielding transcription factors, enzymes or transport related/signaling proteins. Bacterial pathogens to acquire iron from available sources, have evolved membrane receptors for capturing iron-loaded-hTF, transferrin binding proteins A and B (TbpA/TbpB). This interaction is essential for the pathogenicity of many critical human pathogens, such as Neisseria sp (gonorrhoeae, meningitidis). Our aim is to investigate the structural dynamics modulated by iron binding and release and how such are affected by the receptors in the presence or absence of drugs, following a three-pronged approach: a) Determine the structural dynamics of hTF upon iron binding in the two bilobed structures and uncover the allostery between them, b) Map the structural changes triggered by hTF-TbpA-TbpB interactions that underlie the iron release mechanism, c) Identify drugs that compromise the hTF-TbpA interacti