RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Anti-fraud milk - electrical impedimetric and ultrasonic control system to detect fraud (adulterations) of milk' (AFRAMILK).

assistant: **Innovation**

AFRAMILK is an RTD project and complies with the general socio-economic objectives of the Generic Activity 2: 'Measurements and Testing' . More specifically, the proposal meets the objectives and modalities: Anti-fraud, Instrumentation, 6.1.2 Periodic Call. The objectives are (i) determine the percentage of fat and water, (ii) determine the freshness (rnicrobiological quality), (iii) determine the addition of low-cost milk to milk of higher costs, and (iv) detection of illegally used substances (toxins, antibiotics) . The technical result of the project is a multi-sensor system based on PC-based equipment for the detection of the most common adulterations and frauds of milk. This system will use impedance spectroscopy, ultrasonic measurements, and special sensors with recognizing coatings (lipids, antibodies).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Coordinating energy security of supply actions' (CESSA).

assistant: **Concept**

CESSA consists in creating and managing a energy policy European forum. It aims at contributing to an economically feasible, socially acceptable and environmentally friendly energy policy in the EU. CESSA involves high-level decision-makers from industry and business as well as from public authorities and European and international organisations. Committed Stakeholders of CESSA (48 in total) include inter alia 10 national regulatory authorities and 2 international energy organisations; 5 transmission system operators or associations of energy infrastructure; 4 associations of energy consumers; 14 large European energy companies and 6 associations of energy companies. CESSA groups more than 20 experts or first-ranked scholars who are also experienced with policy assessment and expertise in more than15 countries.  To nurture the forum, the leading CESSA research institutions will address the following issues:  (i) Nuclear Contribution to EU Energy, Environment and Security Needs  (ii) Economic Mechanisms and Policy Guidance for Sustaining a Robust Development of European Gas Supply  (iii) Barriers and Prospects towards a European Hydrogen Economy  (iv) Coordinating Security of Supply in the EU. For all those issues, CESSA will review the existing national and international studies, will point out the costs of the lack of a coordinated energy policy in Europe, will identify where there is room to develop such cooperative actions, and will draw guidelines for implementing them.  In doing so, CESSA will deliver a contribution to the Strategic EU Energy Review" announced in the March 2006 Green Paper "Energy Strategy for Europe""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Errors as cost-optimizing decisions? Redefining the origin and nature of human decision errors in light of associated neural computations' in the context of a Horizon 2020 call.

assistant: **Objectives**

Making decisions, from simple perceptual judgments to complex policy-making orientations, often requires to combine multiple pieces of ambiguous or conflicting information. In such uncertain conditions, human decisions exhibit a suboptimal variability whose origin remains poorly understood. Dominant psychological theories attribute the resulting errors to imperfections at the peripheries of an otherwise optimal inference process, and consider them essentially as failures of human cognition. Instead, my research program seeks to redefine decision errors not as cognitive failures, but as cognitive compromises which optimize a trade-off between the expected accuracy of a decision and the cost associated with neural computations required to reach this accuracy. I hypothesize that human decision errors arise to a large part from the limited computational precision of probabilistic inference, and that humans adapt this precision to the cognitive demands imposed by their environment - by increasing it when it is deemed necessary or decreasing it when they can rely on 'cheaper' sources of information to decide. I propose to test this original research hypothesis using a combination of computational modeling and multimodal functional neuroimaging of human decision-making. The degree of generality of the obtained findings will be assessed by bridging research across two types of decisions historically studied separately: perceptual decisions and reward-guided decisions. I will also test the clinical relevance of the hypothesized 'accuracy-cost' trade-off for two psychiatric conditions associated with dysfunctions of decision-making under uncertainty: 1. the emergence of false beliefs in schizophrenia, and 2. the repetitive checking behavior observed in obsessive-compulsive disord
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Comparative HaplotypOmics of Parthenogenetic Plectus nEmatodes' (CHOPPE) under Horizon Europe.

assistant: **Objectives**

Sexual reproduction is a costly but seemingly necessary trait in animals. However, species in diverse branches of the animal kingdom have secondarily reverted to asexual reproduction. In the roundworms (phylum Nematoda), this reversal appears particularly frequent, as parthenogenetic species have emerged in numerous genera. Species in the genus Plectus are obligately parthenogenetic, and are distributed in non-extreme and extreme environments across the globe. Mechanisms leading to the loss of sex, for example hybridisation, have received some attention, but are still poorly understood, in particular on the genomic level. This is in part due to the lack of sequencing and analysis tools for complex genomes of minute organisms.CHOPPE will generate chromosome-level collapsed and phased genome assemblies using latest assembly strategies for several species of Plectus and its closest sexual relative Anaplectus from diverse habitats. CHOPPE will develop new computational methods for generating fully phased assemblies of diverse non-model species. Collapsed assemblies, and haplotype assemblies of several Plectus and Anaplectus species generated in the project, will allow to decipher the genomic basis of their adaption in the context of parthenogenesis and extreme environments.  The project will further investigate the reversal to sexuality of Plectus through crossing with heat induced males, and establish this genus as a new model for the study of parthenogenesis.


**Keywords:** Genome assembly, Haplotypes, Parthenogenesis, Adaptation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Development of digital radiography techniques, sensors and systems to replace film radiography for defect detection in safety critical welds and castings'.

assistant: **Concept**

Within the European Community there are over 110 refineries, 400 chemical plant and an estimated 10 millionkilometres of interconnecting and transmission pipelines and pipe-work. An estimated 40% to 50% of thepipelines/pipe-work are directly accessible for Non Destructive Testing (NDT) and inspection. The majority ofthe pipe-work and vessels carry toxic and/or flammable fluids, at high temperature and pressure where breach ofcomponent containment can have considerable safety, environmental and economic implications. There is anestimated 200 offshore oil and gas production installations operating within European waters with thousands ofkilometres of critical topside accessible pipe-work. Digital radiography will allow safer, faster and moreeconomical 'in-situ' radiography to be undertaken on pipe work welds and parent material thus helping meetEuropean safety, environmental and social objectives.The aerospace and automotive industries throughout Europe produce millions of steel and alloy precisioncastings each year, many of which are used in safety critical applications. In the main the current practice is toexamine using film radiography 'off-line' of the casting production process. Digital direct radiography willsignificantly reduce the inspection cycle inspection time by allowing the radiography to talk place 'in-line' at thefoundry.The consortium SME's aim to develop digital radiographie systems to meet the stringent defectdetectability requirements of the petrochemical, aerospace and automotive industries. A step change in theuse of'in-line' and site radiography is intended, such that the safety, environmental and economicsbenefits to industry are compelling. Hence, the consortium SME's will access the 500 million Euro per annum,in-service inspection market for pipe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Continuous Blood Glucose Monitoring and automated therapeutic closed loop medical device for Intensive Care Units'.

assistant: **Innovation**

Intensive Care Units (ICUs) require careful monitoring of blood glucose levels and insulin infusion to keep patients within safe physiological levels. Fluctuations of blood glucose are directly related to an increased risk of death and comorbidities. However, blood glucose monitoring (BGM) is still made by intermittent and manual offline analysis of blood samples. This technique proves inefficient (need 17% caregivers time), costly (€300 per patient) and increments mortality in hospital ICUs by 40% due to irregular glucose level adjustments upon measurements. After 15+ years of experience in developing glucose monitoring sensors, we at TRACE are taking on our next big step to penetrate the medical device sector with ContiTRACE: an AI powered automated non-invasive medical device for continuous BGM. Our patented ContiTRACE is able to measure glycaemic levels every 2 minutes (automatically) and automatically infuse insulin when needed. It is also capable of self-calibrating and has standardized body accesses, enhancing safety and minimising discomfort for the ICU patient. This will allow 1) caregivers to decrease their workload, 2) doctors to take informed decisions and 3) the healthcare system to optimize their limited human, economic and material resources by providing savings of more than 50% of BGM related cost. Our business model is twofold. We will sell the medical device (5 years lifecycle), and the consumables (max. 4 days duration per set) to private and public hospital ICUs. Our draft forecast (2022-2026) estimates profits of 14.4 M€ with a Return on Investment of 10.7 by the 5th commercial year allowing us to increase x10 our company headcounts in five commercial years. Although newcomers to the medical sector we have the support of key players among regulatory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Disruptive technology for the identification, quantification and prediction of the evolution of damages in civil engineering structures that increases safety while reducing maintenance costs.'.

assistant: **Objectives**

Our company (IDVIA) is a Spanish engineering consulting company with more than 9 years of experience in the field of Civil Engineering. During the last three years we have worked to develop PAROST, a solution capable not only of identifying, locating and quantifying damage of road bridges and road tunnels, but also of predicting accurately how such damage will evolve in the future. This characteristic makes PAROST a disruptive innovation compared to the structural health monitoring (SHM) systems that exist in the market that only provide information about the current situation. Thanks to this prediction capacity, PAROST can avoid catastrophes such as the collapse of the Morandi bridge in Genoa (Italy) on August 14, 2018, which could unfortunately become increasingly common since most of the tunnels and bridges in Europe were built between the 1950s and 1970s. In addition, PAROST will provide to infrastructure managers the needed information to create predictive maintenance plans which will allow them to save up to 62% of their annual maintenance cost. In global figures, PAROST will improve safety while reducing maintenance costs of 507.200 road bridges and 46.904 road tunnels in Europe by 8.452M€/year.By year 3, we expect to have installed PAROST in 384 civil engineering structures (bridges and tunnels) of the European road network. As a result, revenues for our company will be 20.2 M€ with a net profit of 11.8 M€, and 6 new highly qualified jobs will be created.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Late Clinical Development of KH176: an innovative orphan drug to reach mitochondrial disease patients & market' in the context of a Horizon 2020 call.

assistant: **Objectives**

Mitochondrial diseases are chronic progressive disorders for which no cure exists, affecting approximately 250,000 patients worldwide. KH176 is a proprietary small molecule designed by the Dutch SME Khondrion BV to treat a large group of rare mitochondrial and related diseases. With KH176, a new redox-modulator, Khondrion aims to stall disease progression and revert clinical complaints in mitochondrial diseases; it corrects cellular consequences of mitochondrial dysfunction and has broad market potential. Khondrion’s management has >25 years experience in mitochondrial medicine, patient care and drug development, and is supported by highly experienced entrepreneurs. Since 2012, Khondrion completed preclinical, Phase 1&2a clinical, EMA&FDA orphan drug designation providing market exclusivity, and has a strong patent portfolio. Khondrion operates in a small but highly lucrative niche market. The addressable market for KH176 is 50,000-250,000 mitochondrial disease patients in Europe&US. Base-case cumulative revenue on KH176 is expected €35M by 2024, a return of >10 times this grant. Worldwide orphan drug sales are to increase at 11% CAGR to $209b in 2022; orphan drugs are projected to account for 21.4% of worldwide prescription sales by 2022 (excl. generics) from 6% in 2000. Worldwide, Khondrion is one of few SMEs devoted to develop a drug for mitochondrial diseases. Khondrion follows fast, risk-reduced development for KH176; first market approval in adult patients (MELAS/MIDD), entering expedited authorization for other mitochondrial diseases. As spin-out, Khondrion aims licensing KH176 for major indications (preclinical data on KH176 in genetic forms of Parkinson’s completed). Financing of this KHON2bTREAT project by the EIC SME instrument Phase 2 will enable Khondrion t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Decarbonising energy-intensive industries with renewable synthetic fuels' (DESIRE).

assistant: **Concept**

The future energy mix will include a variety of fuels. E-fuels allow to store the excess renewable energy into high energy-density chemical compounds representing the ideal candidates for energy transition in Energy Intensive Industries (EIIs).The DESIRE network will train the next generation of specialists in exploring the use of e-fuels, in existing combustion devices, to better guide the energy transition and to help the decarbonization of EIIs in Europe. The academic and industrial partners of DESIRE will work synergistically to generate a cohort of 15 well-trained young scientists with inter-disciplinary skills in combustion science, mechanical and chemical engineering, computer science and modelling that will be ready to propel and advance future engines towards pollution control, fuel-flexibility and higher efficiencies. Such a broad spectrum of training is currently lacking due to the fragmentation of the emerging field of sustainable combustion across Europe. Perhaps more importantly, the need, nature and magnitude of these new skills is only now emerging. The DESIRE network will equip its Doctoral Candidates with a unique combination of skills essential to become future research leaders or entrepreneurs in the sustainableenergy sector. They will drive this research field forward and accelerate the energy transition.The main scientific goal of DESIRE is to develop predictive tools including mathematical-numerical models and experimental measurement techniques able to describe the combustion of e-fuels that can then assist engineers in designing new technologies and/or modifying/adapting existing combustion equipment and technologies to be suitable to use these powerful fuels.The program is heavily supported by key-companies in the transport sector (Rolls-Royce,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Immune Functions of Myeloid Syk-coupled C-type Lectin Receptors Sensing Necrosis' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Necrosis triggers an inflammatory response driven by macrophages that normally contributes to tissue repair but, under certain conditions, can induce a state of chronic inflammation that forms the basis of many diseases. In addition, dendritic cell (DC)-mediated presentation of antigens from necrotic cells can trigger adaptive immunity in infection-free situations, such as autoimmunity or therapy-induced tumour rejection. Recently, we and others have identified the myeloid C-type lectin receptors (CLRs) CLEC9A (DNGR-1), in DC, and Mincle, in macrophages, as receptors for necrotic cells that can signal via the Syk kinase. Previous studies on similar Syk-coupled CLRs showed that Dectin-1 and Dectin-2 can induce innate and adaptive immune responses. We thus hypothesise that recognition of cell death by myeloid Syk-coupled CLRs is at the root of immune pathologies associated with accumulation of dead cells. The overall objective of this proposal is to investigate necrosis sensing by myeloid cells as a trigger of immunity and to study the underlying molecular mechanisms. Our first goal is to characterise signalling and gene induction via CLEC9A as a model necrosis receptor in DCs. Second, we will investigate the role of myeloid Syk-coupled necrosis-sensing CLRs in animal models of atherosclerosis, lupus and immunity to chemotherapy-treated tumours. Our preliminary data suggest that additional receptors can couple necrosis recognition to the Syk pathway in DC; thus, our third aim is to identify novel myeloid Syk-coupled receptors for necrotic cells. Characterisation of the outcomes of sensing necrosis by myeloid Syk-coupled receptors and their effect on the proposed pathologies promises to identify new mechanisms and targets for the treatment of these diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'TAWNY - An Artificial Intelligence Project to Make Things Empathic' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The number of things oneThe number of things one can do in a connected and digitized world has become so enormous that no-one is able to actively use even a tiny fraction of all those possibilities, oftentimes leading to a technological overload. This situation has led to the rise of products and services which try to be “smart”, i.e., which try to automatically adapt themselves to the needs and preferences of a user. While at the moment, these smart things require explicit user interaction and feedback to be able to adapt and learn, the TAWNY project aims at introducing the so called “emotional intelligence” - typical in human interaction – in smart products, services, and environments. Based on physiological signals like heart rate and skin resistance – measured with off-the-shelf wearables – and the help of machine learning, TAWNY is able to recognize human affects like emotions, stress, or other kinds of mental state. The technology will be offered as an AI-as-a-Service platform, allowing other developers to easily integrate emotional intelligence into their products and freeing them from having to deal with low-level physiological data directly. Out of the numerous psychological models of interest, the widely-known mental state called ""flow"" – i.e., being highly productive and content at the same time – has attracted interest in talks with potential clients. Preliminary experiments of TAWNY have suggested that flow might be measurable with TAWNY's approach which would allow for dynamically adapting a workplace or task to keep users in the state of flow – a win-win situation for the employer and employee. In the feasibility study, TAWNY wants to run a series of experiments and develop a prototype to validate and demonstrate the flow measurement technology. Additio