RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Chaotic and Bi-Stable Pendulum Energy Harvesters for Ultra Low-Frequency Ocean Waves' (WAVEHARVEST) targeting Horizon Europe.

assistant: **Abstract**

The WAVEHARVEST project advances ocean-based renewable energy by developing a novel bi-stable chaotic pendulum harvester to power Ocean Internet of Things (OIoT) devices. Oceans, covering over 70% of Earth’s surface, are an abundant yet under-exploited renewable source, offering higher energy density and longer availability than wind or solar. However, marine sensors and data buoys, vital for ocean monitoring and maritime safety, remain constrained by limited energy supply. Batteries demand costly maintenance, while solar and wind recharging are hampered by instability and low efficiency in harsh marine environments.WAVEHARVEST addresses this challenge with an innovative pendulum-based harvester tailored to the ultra-low-frequency ocean wave environment. Its design integrates pendulum dynamics, bi-stable oscillations, and chaotic energy transfer, enabling wide-band harvesting beyond conventional narrow-band resonance. This novel configuration improves energy transfer efficiency and ensures sustained voltage generation under realistic sea conditions.The project combines conceptual design, nonlinear modelling, advanced analytical techniques (CX-A, Melnikov analysis), numerical bifurcation studies, and novel stability-informed optimisation with prototype fabrication and experimental validation at the University of Glasgow and QinetiQ. The outcome will be a compact, efficient prototype at TRL 5, with strong potential for future scaling and commercialisation.By enabling self-powered OIoT devices, WAVEHARVEST supports the UN Sustainable Development Goals, particularly the conservation and sustainable use of oceans, and aligns with the MSCA Green Charter by advancing renewable, low-carbon technologies. The fellowship also offers interdisciplinary and intersectoral training in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecular basis of vascular events leading to thrombotic stroke' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Stroke kills about 5 million people annually and is also the leading cause of disability and dementia in adults. Early recognition of individuals at risk for stroke would significantly alleviate the heavy social and economical burdens due to stroke. Advances in identification of vulnerable individuals require development of entirely new strategies. Stroke is triggered by thrombosis occurring after rupture of atherosclerotic plaques, and MOLSTROKE focuses on identifying pathogenetic molecular mechanisms and vascular protagonists defining vulnerable plaques and contributing to plaque rupture. MOLSTROKE assembles 7 partners with multidisciplinary backgrounds and exploits innovative technological approaches together with testing of novel pathogenetic hypotheses. The priority research areas of MOLSTROKE comprise 1) concomitant wide genomic and histoproteomic screening of lesional vascular tissue to identify novel pathogenetic markers, 2) Early inflammatory events, which are the key to atherosclerosis progression and hence primary prevention, and 3) atherosclerotic plaque instability, which leads to the acute clinical thrombotic events. The proposed investigations will implement novel technologies of differential display of unknown genes, vascular tissue arrays and bioinformatic integration of collected clinical and experimental data. Thus, weighted identification of stroke denominators can be accomplished and thereby lead to improved diagnostic and treatment modalities. The research armoury spans genomics, tissue arrays, molecular biology, cell biology, immunology, biochemistry, gene transfer, animal models and integrative bioinformatic software tools. MOLSTROKE will maximize the scientific, educational and commercial potential of the proposal by electronic data-sharing, com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Why do We Need a Realist Constitutional Theory to Study the Politics of Constitutional Change in the Middle East?' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This research programme aims to make contribution to comparative political and legal theory by studying the recent constitutional transformation in the Middle East in at least three grounds. First, in arguing that a constitution always comes into being as a result of a historical process and a decision (will), such historical-sociological context and power relations behind the creation of constitutions can be grappled with best by a realist political and legal theory. A realist approach sees constitutions as the ultimate battleground for the groups competing for power to constitute the foundational norms and values of society. Second, if a constitution is created by a decision, there is always an agency behind that decision that executes its will power. In democratic theory such agency is being defined as the people, but the people cannot manifest its will without a representative (e.g. a class, constituent assemblies, or conventions). To this end, a realist approach carefully examines the agency of Islamic political parties so as to understand the peculiarity of the constitution-making in the Middle-East. Peculiarity here is that the recent revolutions brought Islamic parties to government, but this has only helped destabilizing the new, or present, constitutions and weakening the hope for accommodation of Islamist groups in a liberal democratic and secular constitution. Third, a comparative realist approach examines both the Western and Islamic sources of legitimacy so as to have a nuanced understanding of the contemporary crises of legitimacy which now dominates the entire region. Such comparative study is necessary because the Western (secular) concepts and institutions such as constitution, freedom of association, competitive elections, parliamentarianism and liber
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Urban transport and socio-economic development' (TRANSECON), addressing dissemination and exploitation.

assistant: **Impact**

To review and analyse available evidence and experiences regarding socio-economic impacts of urban transport policies and investments, in Europe and USA To employ several case studies of a range of European cities that have implemented relevant urban transport.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'GRF-mediated regulation of a membrane protein, IRT1, involved in metal uptake' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Iron (Fe) is one of the most common metals in the Earth's crust, but plants are often unable to absorb it as it forms insoluble complexes, especially in alkaline soils. This unavailability leads to poor crop yields and low nutritional quality. As Fe fertilization is rather ineffective and costly, around half of the world's crops suffer from iron deficiency. To mitigate Fe deficiency symptoms and maintain nutrient homeostasis, plants rely on a protein called Iron-Regulated Transporter 1 (IRT1) to take up iron from the soil. However, IRT1 also absorbs other metals that are more easily available in Fe-deficient soils. These metals can be harmful to plants if absorbed in excess, causing damage to cellular compounds through the formation of reactive oxygen species. To limit this toxicity, IRT1 is able to sense metal excess, leading to its degradation to avoid further uptake. To better understand this feedback loop, previous work from the host laboratory uncovered interactants of IRT1 under non-Fe metal excess, including General Regulatory Factors (GRFs) which are known to modulate the functions of their targets by controlling their subcellular localization or cell polarity, preventing their degradation or allowing their interaction with additional partners. The GIFT project aims to uncover how plants balance iron uptake and protect themselves from excess of harmful metals to eventually improve crops development and reach better yields. To this avail, I will (1) investigate the involvement of IRT1-interacting GRFs in plant metal homeostasis through molecular and physiological analyses of plant metal excess responses; (2) decipher the molecular mechanisms governing the association of GRFs to IRT1; (3) and elucidate their putative role in the control of IRT1 subcellular localiz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'GLOBAL SOLUTION FOR SLAUGHTERHOUSES, TANNERIES AND PHYTOSANITARY SECTORS: TREATMENT OF CATEGORY 3 ANIMAL WASTES AND PRODUCTION HIGH VALUE PRODUCT WITH BIO-PESTICIDE PROPERTIES' (APTAR).

assistant: **Innovation**

Before the implementation of the new European Regulation1 (3 October 2002) because the break out of Bovine Spongiform Encephalopathy (BSE) most animal wastes were gathered by specialised companies for transforming them into other derivatives (i.e. feeding flour of animal origin) that have caused multiple problems of infections in all Europe known in the 90s as “Mad Cow Disease”. Nowadays, those waste disposals should be controlled as it is banned by the European Decision were indicated that “all mammalian protein sources are prohibited from use in animal feeds”2. Therefore, the sectors affected (tanneries and slaughterhouses) have had to control the disposal of their animal wastes. Indeed, since 3 October 2002 when entered into force the European Regulation (EC 1774/2002), tanneries and slaughterhouses have had to assume extra costs for the disposal of their animal wastes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Rapid interaction profiling of 2019-nCoV  for network-based deep drug-repurpose learning (DDRL)'.

assistant: **Concept**

We aim to identify approved drugs that can be repurposed for the treatment of 2019-nCoV using interactome profiling and deep-learning. We will deploy rapid high-throughput protein-protein interaction mapping and computational protein-RNA interaction predictions to chart the coronavirus host interactome network (CoHIN), which will become a public resource for translational and basic coronavirus research few months after project start. CoHIN will serve as input into an existing deep-learning model to identify approved drugs that are likely effective against 2019-nCoV, which will be validated in in vitro and in vivo systems. In the second stage we will experimentally determine the matrix of viral protein alleles vs. variants of the interacting human proteins to understand how human and viral natural variations jointly mediate disease severity in different individuals. These data will be integrated with epidemiological and human genomics data to improve risk management and improve preparedness for future coronavirus outbreaks. Overall, we aim to achieve the following objectives:  - Map the protein interactome of 2019-nCoV and related Coronaviridae with their human host  - Generate the allele interaction matrix and relate differences to epidemiological data - Develop a microarray-based patient screen to detect exposure to 2019-nCoV and identify immunogenic epitopes  - Identify 10 approved drugs that are most likely efficient against 2019-nCoV using network integration and deep-learning  - Validate drug candidates in in vitro and in vivo systems


**Keywords:** Virus-Network Drug-Repurpose DeepLearning Molecular-Interaction-Profiling Protein-Interaction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'The convergent synthesis of vitamin d3 anlaogues'.

assistant: **Innovation**

Research objectives and content Since early work established between vitamin D3 and rickets, the importance has emerged of vitamin D3 and the hormonally active form, la,25-dihidroxyvitamin D3 1 in a number of disease funtions. recent research suggests that 1 has potential as a treatment for psoriasis, and for certain cancers. effective chemotherapy must combine lo hypercalcemic action with high anti-cancer activity and the search has begun for analogues which meet these criteria. We propose to develop a general synthetic strategy for the assembly of analogues of 1. The strategy has been devised so as to combine optimal convergence, brevity and stereoselectivity in such a way that it will be possible to synthetize a structurally diverse range of vitamine D3 analogues hitherti inaccesible using established semi-synthetic or degradation based methods. The key disconnections are shown in Scheme. It is proposed to established the intermediancy of 'southern hemisphere' and 'northern hemisphere' fragment 3 and 4, which will be joined using transition metalmediated coupling reactions to give structures exmplified by triene 2. The functionality necesary for the connecting of 3 and 4 in this way will be incorporate directly from the strategy-level transformations used in their synthesis, requiring only minimal manipulation of the products of these reactions immediately prior to the crucial coupling reaction. attachment to C-22 of a variety of nuclephilic side-chain units will be accomplished using established methods of olefination and alkylation. Training content (objective, benefit and expected impact) This project will be very useful to the training of the candidate because I should develop synthetic methods which are important for our research group in Spain. Secondly, I will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Combating cancer through novel approaches to protein-protein interaction inhibitor libraries' to be submitted under Sixth Framework.

assistant: **Abstract**

The objective of CAPPELLA is to develop a series of innovative small-ligand tools and libraries that allow new approaches to the inhibition of protein:protein interactions (PPI) in cancer.The inhibition of PPI is one of the most promising approaches to the development of novel cancer therapies. Because many PPI occur within the cell they can only be targeted by small molecules. But because PPI differ structurally from more classic drug targets such as enzymes and receptors, existing compounds have generally delivered disappointing results. New approaches are needed. The partners are state of the art" in the research areas addressed. The project is a unique opportuniy to integrate novel insilico, chemical, genetic and ADME-based approaches to the design, synthesis and optimization of libraries and compounds. A key theme is the utilization of structural motifs found in natural PPI inhibitor compounds. This is coupled with high tent testing of the resultant structures on 3 distinct PPI targets relevant to different types of cancer, to allow compound rule-sets to be developed and improved. This project brings together some of Europe's leading biotech SMEs and several highly recognised academic institutes. By combining 5 distinct chemical approaches and testing them on 3 different targets (all from different partners) in three successive but repeating cycles the project mobilises resources from across Europe. All 9 partners have experienced teams and the coordinator's staff has experience of 7 prior EU projects. Each year there are about 10.9 million new cases of cancer and 6.7 million deaths. In Europe, 46% of cases are in women. By providing new approaches to a promising but challenging target class, perhaps 50% of cancer patients could one day benefit from the findings. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Non-Destructive EValuation, Inspection and Testing of Primary Aeronautical Composite Structures Using Phase Contrast X-Ray Imaging""' under Seventh Framework.

assistant: **Concept**

The objective of this proposal is to further focus on the application and appropriate adaptation of Phase Contrast X-ray imaging technology for the Non-Destructive Evaluation and Inspection of primary aeronautical composite structures, both during the manufacturing process and during the repair and re-use of key components. The introduction of this new methodology is expected to provide the aeronautical industry with a more detailed insight of the internal structure of thin and particularly challenging thick composite structures as well as complex geometry ones such as integrated  closed boxes and sandwiches, enabling the prompt detection of micrometer defects deeper in the composite structure, compared to the state-of-the-art technologies. It is expected that the proposed novel non-destructive technology methodology will help achieve the goals of reduction of aircraft weight through lowering the safety factors, as a detailed and highly reliable knowledge of the internal damage status of primary structural elements will be enabled. At the same time, it will also help reduce the aircraft development cost because this new technique will be introduced in the inspection and quality control during the manufacturing process.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Robust Advanced Materials for metal Supported SOFC' (RAMSES).

assistant: **Innovation**

The RAMSES project aims at developing an innovative high performance, robust, durable and cost-effective Solid Oxide Fuel Cell based on the Metal Supported Cell concept i.e. the deposition of thin ceramic electrodes and electrolyte on a porous metallic substrate. Both planar and tubular cells will be developed. By considering advanced materials tailored for this cell design, such cells will be able to operate at 600°C on methane steam reforming, with an ASR of 0.8 Ohm.cm² for planar cells and 1.0 Ohm.cm² for tubular cells and a degradation rate of 30 mOhm.cm²/khr. In addition it will be able of withstanding thermal/redox combined cycles. The achievement of such performance needs several key-developments to be addressed: first the manufacturing of a durable metallic substrate; second the deposition of the ceramic layers without affecting the substrate microstructure, with a special emphasis on the dense electrolyte deposition; third the proof-of-concept via the integration of the cells into a short stack, supported by inspection techniques to evaluate the good quality of components at each step of the process; and finally testing activities to determine the performance and durability of cells and stacks, and to investigate specific identified failure mechanisms.A cross multidisciplinary consortium has been defined to obtain each competence needed for the project, gathering 9 organisations from 4 member states (France, Italy, Sweden, Spain) and one associated country (Norway). In addition an IPHE country (Canada) with a significant background in the development of Metal Supported Cells will be associated to this project.The partnership covers all competences necessary to develop the new SOFC, embracing powder suppliers (HÖGANÄS, BAIKOWSKI), experts in materials and cell d