RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Profiling the toxicity of new drugs: a non animal-based approach integrating toxicodynamics and biokinetics' in the context of a Seventh Framework call.

assistant: **Objectives**

The overall aim of Predict-IV is to develop strategies to improve the assessment of drug safety in the early stage of development and late discovery phase, by an intelligent combination of non animal-based test systems, cell biology, mechanistic toxicology and in-silico modelling, in a rapid and cost effective manner. A better prediction of the safety of an investigational compound in early development will be delivered. Margins-of-safety will be deduced and the data generated by the proposed approach may also identify early biomarkers of human toxicity for pharmaceuticals. The results obtained in Predict-IV will enable pharmaceutical companies to create a tailored testing strategy for early drug safety. The project will integrate new developments to improve and optimize cell culture models for toxicity testing and to characterize the dynamics and kinetics of cellular responses to toxic effects in vitro. The target organs most frequently affected by drug toxicity will be taken into account, namely liver and kidney. Moreover, predictive models for neurotoxicty are scarce and will be developed. For each target organ the most appropriate cell model will be used. The approach will be evaluated using a panel of drugs with well described toxicities and kinetics in animals and partly also in humans. This approach will be highly advantageous as it will allow a direct comparison between the in vivo to the in vitro data. A parallel analysis of several dynamic and kinetic models with a broad spectrum of endpoints should allow for the identification of several relevant biomarkers of toxicity. Inter-individual susceptibilities will be taken into account by integrating the polymorphisms of the major drug metabolizing enzymes and correlating the observed effects in the human cell mode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Autonomous Printed Paper products for functional Labels and Electronics' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

A new generation of sustainable paper products with specific autonomous functionalities aiming at interacting with their users and/or reporting changes in their environment is developed. The project focuses on the development of new functional materials (paper, fibres, inks), new functional components (battery, sensors, display, memory) and innovative, flexible and cost-effective manufacturing processes based on printing and embedding techniques for the integration of all these functional components on the smart paper substrate.The new APPLE products make extended use of the specific properties of both fibre based products and (nano)fibres individually: the paper is not only used as substrate providing the required mechanical, surface and barrier properties for the printing and integration of the functional components but also the fibres including the incorporation of nanofibres are used as active elements, namely the display and the memory.The new cost-effective manufacturing process based on printing and embedding techniques with a new quality-controlled, flexible concept developed, will open new opportunities for the paper and printing industries (132 000 printers in Europe, among which 85% are SMEs) in the growing market of low-cost and high value added printed electronics.The aim is to demonstrate the new products for target applications: 1) Environment & safety labels, 2) Environment & advertising posters and 3) Smart packaging labels.The project also aims at paving the way for further development of flexible low-cost manufacturing processes of other new high value added products through the integration of latest sensor, energy sources and ICT technology in order to meet societal needs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'An Efficient Software Tool For Global Data Access' (GLOBDATA).

assistant: **Concept**

The growing diffusion of Internet and Wide Area Networks, allows the creation of distributed Information Systems spanning entire continents. A system of these characteristics makes possible to have on-line large elements of information that can be considered as distributed objects. The software engineering process requirements due to the shared objects are not well handled by using traditional database methods. GlobData will produce COPLA, an efficient software development and support system, to provide application developers with a global view of an object database repository, with transactional access to geographically distributed objects independent of their location, allowing them to efficiently work against a single logical object environment.Objectives:The overall objective of GlobData can be structured in three different levels:* A strategic objective, to solve the problem of efficiently access large amounts of information geographically distributed* A technological objective, to create an innovative, transparent and portable platform for global application development requiring at the same time minimum changes in user methodologies.In particular, subobjectives of this one are:- Implementation of an architecture and API for building applications for geographically distributed environments.- Implementation of an architecture to integrate data sources to support applications.- Implementation of the security and consistency mechanisms needed for an efficient data interchange among the geographically disperse sites- Development of 2 testbed applications* A business objective, to disseminate the use of COPLA through a sound exploitation plan so it can become widely availableWork description:COPLA will be an integrated software package to be distributed to application
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Microplastics: morphological and genetic developmental effects in a marine invertebrate.' (MICRODEV) targeting Horizon 2020.

assistant: **Abstract**

Plastic debris contamination is a growing environmental concern in marine habitats. Large plastic objects break-up over time to create micro- and nano- particles, collectively called microplastics (MP), which account for the overwhelming majority of plastic particles in the sea. Little is known about the impacts of MP on wildlife or humans and this presents an important research priority. Several studies have demonstrated that MP can affect sea life negatively. Amongst these, they have been reported affecting development (causing malformations, delayed growth and increased death rates). These developmental effects have never been characterised, and their molecular basis remains unknown. Developmental defects may impact population survival by decreasing the number of individuals, or their fitness, in range of marine organisms.This pioneering project will identify the effects of MP exposure in the development of the sea urchin Paracentrotus lividus, bridging interests for ecology, toxicology, developmental biology and aquaculture. I will characterise the developmental morphological malformations caused by MP and their underlying genetic mechanisms.This Fellowship will provide an excellent opportunity to complement my strong background in genetics and molecular and developmental biology and expertise in ecotoxicology and microplastic pollution with transcriptomic analysis and the deep understanding of this model organism for development and toxicology under the supervision of Dr. Arnone, a world leading expert in the field. This will provide me with a firm skill set and knowledge to further my research career. The knowledge and expertise I will acquire in the Arnone lab, together with being hosted by a supportive and acclaimed institution, and the prestige of the MSCA fell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Development of Exposure Scenarios for Manufactured Nanomaterials'.

assistant: **Objectives**

Nanotechnology is a fast growing industry producing a wide variety of manufactured nanomaterials (MNMs) and numerous potential applications. Consequently, the potential for exposure to humans and the environment is likely to increase. Human exposure to MNMs and environmental release of these materials can occur during all the life cycle stages of these materials. For each stage of the life cycle of an MNM, exposure scenarios will need to be developed that effectively describe how exposure to humans and the environment occur and what measures are required to control the exposure. The aim of the NANEX project is to develop a catalogue of generic and specific (ocupational, consumer and environmental release) exposure scenarios for MNMs taking account of the entire lifecycle of these materials. NANEX will collect and review available exposure information, focussing on three very relevant MNMs: (1) high aspect ratio nanomaterials - HARNs) (e.g. carbon nanotubes); (2) mass-produced nanomaterials (e.g. ZnO, TiO2, carbon black); and (3) specialised nanomaterials that are currently only produced on a small scale (e.g Ag)). The exposure information will include both quantitative (measurement results) and qualitative contextual exposure information (risk management measures). We will also review the applicability of existing models for occupational and consumer exposure assessment and for environmental release from these scenarios. We will carry out a small number of specific case illustrations and carry out a gap analyses of the available knowledge and data. Finally, we project knowledge will be disseminated to relevant stakeholders, taking into account other relevant activities that are taking place in this field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Evaluation of sustainability: European conferences and training courses EASY-ECO 2005 - 2007""' (2002-2006).

assistant: **Innovation**

EASY-ECO 2005-2007 is a training and conference programme on evaluations in the specific context of sustainable development. The topic is important because:(i) evaluations support institutional reforms and good governance in knowledge-based societies,(ii) Europe is positioning itself as advocate of sustainable development and(iii) sustainability evaluations are different from conventional evaluations and therefore require specific training opportunities.EASY-ECO 2005-2007 consists of 3 conferences and 4 training courses. By training young researchers hands-on, the training courses address the urgent need for sustainability evaluations and support institutional capacity building. The training courses are hosted in CEE countries because the need for sustainability evaluations is most urgent there. The conferences, all hosted in Western Europe, enhance mobility between old and new member states, support the training of young researchers and aim at scientific impact.The training courses are based on an already develop ed blueprint: In a 3-months virtual preparation phase, young researchers are selected and effectively prepared for the 10 day training phase at the location. In the training phase they go through 8 core courses and a good practice case study. Thereby, complementary skills play an important role. Individual scientific support and networking activities are continued in a 3-months virtual follow-up phase.The 3 conferences support the training of the young researchers by providing them with an international scientific platform, framing the series of events and helping to develop the details of the training course curricula. Scientific impact can be expected from the exchange between scientists and practitioners and the in-depth coverage of a specific topic. The to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Satellite investigation services for the environmental legal/insurance market' in the context of a Horizon 2020 call.

assistant: **Objectives**

While environmental legislations have multiplied across the globe, too often they mostly exist on paper. In Europe only, the gap between policies and practices costs society €50bn per year. The absence of available and reliable data to constitute evidence remains a major obstacle for the enforcement of environmental law. To face this challenge, we developed a market-creating innovation to help victims proving infringement of environmental law and/or assess the damage they suffered. We analyse satellite data to produce reports carefully designed to be directly presented in front of a judge. The applications range from operational monitoring of deforestation & threats to protected habitats, maritime pollution as well as soil pollution. Targeted clientele covers all professionals seeking to have quick access to imagery proving infringement evidence in the frame of their environmental litigation case. Overall, we estimated our total addressable market (TAM) at 537M€/y.Currently, we serve legal professionals seeking to prove illegal mining activities or prohibited forest exploitation (CybELE reports). In parallel, we are developing a new digital solution to detect illegal environmental activity (Cybele SaaS platform). A Minimum Viable Product (MVP) reaching TRL 7, the Platform of Observation for SEa investigations Deducted by Optical Network (POSEIDON), has been developed to constitute the first segment of the CybELE platform.Our business strategy is to progressively shift from tailormade reports to automated products directly available via the SaaS platform.  The general business model may be summarized as a “one-to-many cloud-based SaaS (Software As A Service) ensuring the distribution of EO legal environmental products and services to the B2G and B2B markets ”.The focus o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The role of noradrenaline in human perception: from single neuron to whole brain and behavior'.

assistant: **Innovation**

How do external events become part of our subjective reality? Correlative evidence suggests that the locus coeruleus-noradrenaline (LC-NE) system might play a key role in this process: LC-NE activity is markedly reduced in sleep and anesthesia and reinstated upon recovery of conscious perception, while during wakefulness it correlates with markers of conscious perception. However causal evidence, as well as sensitive experimental paradigms that carefully manipulate awareness in this context, are absent. This proposal aims at providing this missing causal link by pharmacologically manipulating NE levels bi-directionally in healthy volunteers performing liminal visual and auditory perceptual tasks, while reporting their subjective perceptual state. Neural signals will be recorded using simultaneous EEG-fMRI allowing high spatio-temporal resolution. If indeed NE plays a causal role in enabling conscious perception then reduced NE activity will increase perceptual threshold and give rise to impoverished neural responses, whereas enhanced NE activity will aid perceptual incorporation and effectively drive neuronal activity in high-order cortical regions. In a complementary set of experiments I will use a rare opportunity to record single-neuron and LFP activity from neurosurgical patients performing the same perceptual tasks while using pupillometry as a proxy for momentary NE levels. The exceptional signal-to-noise ratio of these recordings will allow linking precisely localized neuronal activity, momentary NE levels, and perception on a trial-by-trial basis, thereby refining and extending the EEG-fMRI results. The ability to manipulate and measure NE levels in subjects reporting their subjective state in sensitive perceptual paradigms, together with comprehensively examini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Clinical ultrasound platform for the quantitative and longitudinal imaging of theranostics and cellular therapy' (CONQUEST).

assistant: **Concept**

The success of modern medical treatments such as cellular therapy and targeted treatments requires appropriate tools for in vivo monitoring. Imaging modalities, such as magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT) and positron emission tomography (PET) are key candidates due to their noninvasive nature. However, these imaging techniques are extremely expensive and can involve radiation, both of which hinder their longitudinal and repetitive use.Ultrasound has so far been unsuitable due to the absence of a label to differentiate regions of interest from tissue background, the main problem being that current ultrasound contrast agents (CAs) have active lifetimes in the order of minutes. The CoNQUeST platform (Clinical Nanoparticles for Quantitative Ultrasound with high STability) proposed here is an entirely new type of ultrasound CA that is extremely stable (lifetime of a year) and is not affected by insonation. This mechanism of contrast generation appears completely novel: The polymeric particles are under 200nm in diameter and must contain a soluble metal (M.Srinivas et al., patent pending, filed 09/2012). Based on the current state of the art, these particles are too small and do not contain the requisite gaseous component for ultrasound contrast.CoNQUeST particles are applicable to longitudinal and repeated imaging, as is necessary for cell tracking, due to their stability. Furthermore, these particles can be chemically bound to targeting agents, dyes and drugs, and are suitable for multimodal imaging, including MRI (both 1H and 19F), fluorescence and SPECT. Finally, the CoNQUeST agents are suitable for clinical use.I propose the application of the CoNQUeST agents to a clinical trial for tracking dendritic cell therapy in mela
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeted vectors for cancer gene therapy: receptor and tran-scriptional targeting of retroviral, lentiviral, and adenoviral vectors' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Ongoing anti-cancer gene therapy clinical trials have highlighted the need for more efficient and safer vectors. Thus, we will develop novel targeted viral vectors for applications to cancer gene therapy. The targeting strategies will be implemented in retroviral, lentiviral, and gutless high capacity adenoviral vectors. Targeting viral vector particles to predetermined cell types will be obtained through genetic engineering of retroviral envelopes or adenoviral capsid proteins, by using single chain antibody fragments or tumour cell receptor ligands.Transcriptional targeting of transgenes expression to tumour cells will be obtained using tumour cell type specific promoter. All vectors will express a reporter/suicide gene, and they will be tested using in vivo models of liver and brain tumours. The characteristics, efficiency, and toxicity of the novel vectors will be compared to standard vectors in current use. This proposal brings together European leaders with expertise covering from the development of novel viral vectors to the implementation of clinical trials of gene therapy.ObjectivesOur general objective is the development of new generations of targeted viral vectors for the treatment of liver and brain cancer by directing viral entry and by restricting transgene expression.Our specific objectives are to obtain: i) targeted retroviral and lentiviral vectors, by engineering retroviral envelope proteins to redirect retroviral entry to tumour cells expressing specific receptors, and by the use of cell type specific promoters; ii) gutless adenoviral vectors, by genetic modifications of the fibre and hexon proteins of the adenoviral capsids, as well as through the use of combined cell type specific and inducible promoters.The characteristics, efficiency, and toxicity