RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Epigenetic regulation and monoallelic gene expression: the X-inactivation paradigm and beyond' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

X-chromosome inactivation (XCI) represents a classic example of epigenetics in mammals. In this process, one of the two X chromosomes in females is converted from an active into a clonally heritable, inactive, state during early embryonic development, to ensure dosage compensation between the sexes. This process is also remarkable in that an entire chromosome is silenced while its homologue, present in the same nucleus, remains active. Thus, in addition to being an epigenetics paradigm, XCI also represents a powerful model for monoallelic gene expression and could provide important insights into the mechanisms underlying other examples of random, monoallelic regulation. The key locus underlying the initiation of XCI is the X-inactivation centre (Xic). The Xic ensures the induction and monoallelic expression of a non-coding RNA (Xist) that is responsible for triggering chromosomal silencing in cis during development. We would like to understand the mechanisms underlying the Xic's functions and define whether other, Xic-like loci exist in the genome. Once XCI is established, the inactive state is initially reversible but becomes progressively locked in as development proceeds due to numerous epigenetic marks such as DNA methylation and histone modifications, as well as nuclear compartmentalization and asynchronous replication. In the proposed program, we will exploit our expertise in XCI to develop new lines of research and use novel technologies to investigate monoallelic gene expression, nuclear organization and epigenetics during development. Our main objectives are (1) to understand how monoallelic expression states are established and maintained during early development and (2) to assess how chromosome dynamics and nuclear architecture can impact on these states.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a ventilated solar screen glazing system ('SOLVENT')' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Objectives and problems to be solved: Completion of the development of a novel glazing system having the following characteristics: In summer, it reduces the penetration of solar radiation to the building interior, while allowing an unobstructed view. It lowers the cooling load, saving energy, and decreases thermal discomfort near the glazing, to an extent that may render external shading devices unnecessary. In winter, it allows solar space heating, but increases visual comfort in the heated space by eliminating the glare typical of a direct gain solar openings; prevents local overheating caused by exposure to direct solar radiation; and reduces damage to furniture and equipment in the heated space caused by sunlight. Description of work: The benefits of the proposed glazing system are realized mainly through the conversion of short wave (solar) radiation to convective heat and long-wave radiation. The first stage of the project focuses on the detailed aerodynamic design of the window, and on the development of 'a model of the performance of the window as a function of climatic conditions, aerodynamic design and optical properties of the glazing. The proposed glazing system requires an innovative reversible frame, incorporating two glazing assemblies: a clear glazing (usually double, often with low-e coating) to provide a weatherproof seal, and an absorptive glazing to provide solar control. The two glazing assemblies, and the ventilated channel between them, must be able to rotate together through 180o to enable the transformation from winter mode to summer mode; In each of the two configurations, the glazing assembly incorporating the clear glass must provide a weatherproof seal, capable of fulfilling current performance codes in the window industry. An appropriate f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Eddie – smart neurorehabilitation software', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Traumatic brain injuries (TBIs) are a major public health, medical, and societal challenge globally. In the European Unionalone, an estimated 57,000 deaths and 1.5 million hospital admissions annually have been attributed to TBI. Hospitaladmission rate of 287.2 per 100,000 persons per year.To avoid a chronic phase of disorders, early, long-term, continual, targeted and complex neurorehabilitation for patients ishighly required. The complex neurorehabilitative approach includes a cognitive rehabilitation from early stages of onset.Smart neurorehabilitation software Eddie is a project based on clinical psychological experience, current state of knowledgein neuroplasticity, big data analysing and prediction model based on machine learning and big data analysis. It is theapplication aimed at patients from early onset of treatment who need to restore cognitive function and is designed for longterm neurorehabilitation.Within phase 1 of SME-Instrument we want to elaborate feasibility study with 4 specific objectives -1. Technical verification – test a prototype of the smart neurocognitive rehabilitation software in connection to the upcoming technologies, such as haptics and bionics provide a user friendly interface for rehabilitation, on healthy people. Secondly to test the application for patients with traumatic brain injury.2. Market research - to explore markets in selected European countries – Poland, Germany, Austria and Slovakia.3. Elaborate the IP strategy4. Prepare the feasibility study including the business plan for Poland, Germany, Austria and Slovakia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Monitoring on-line integrated technologies for operational reliability' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives and content Key design drivers behind public transportation systems are reliability and safety. This is achieved by good structural design supported by regular inspection and maintenance. A car for example will be inspected by a qualified mechanic and certified roadworthy. This process adds to the overall life cycle cost of the product, and for complex systems, such as aircraft, it can be a significant proportion. Improved monitoring techniques, combined with improved material properties and better knowledge of materials behaviour has allowed significant extensions to the intervals between overhauls for various types of transportation systems in the past, from airlines to automobiles. It is anticipated that introducing a structural health and usage monitoring system is an important step to further extend these intervals. It is expected that this is not just a benefit for airlines and road transportation operators, but also to the various railway companies now emerging all over Europe. The exploitation opportunities of the technologies in other markets, in addition to the primary fields, are significant. Currently there is interest from the civil and process engineering sector and also some applications are envisaged in the marine engineering community Further areas for exploitation include the chemical transport and storage industries where knowledge of the condition of transportation and containment devices is critical. The objective of MONITOR programme is to develop an on-line health and usage monitoring system based on advanced load monitoring and damage detection technologies. The immediate aim is to achieve a minimum reduction in inspection of 20% within five years of project completion, which if related to civil airliners with a 20 year life, equates t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Institut fuer mikrotechnik mainz gmbh'.

assistant: **Objectives**

Description:The Institut für Mikrotechnik Mainz GmbH (IMM) is a leading R&D facility in the field of micro-technology. Founded in late 1990 by the state government of Rheinland-Pfalz (Rhineland-Palatinate) as a company of public interest, it meanwhile counts more than 220 staff members (esp. physicists, chemists, engineers, technicians and administrators) as well as a number of diploma or PhD students and trainees. For almost a decade it has accumulated a comprehensive scope of process equipment unmatched by any single institution in Europe. In more than 400 national and international projects it has gained expertise in the design, development and fabrication of marketable micro-devices.Application:Transnational Access to the facilities of IMM is granted upon positive evaluation of proposals by an expert panel following a Call for Proposals. Such calls are issued at least once a year. Details on envisaged dates can be learned from our website or directly from the project manager.Project Manager:Dr. Stefan Kiesewalter, Marketing Department, International Markets and Customers Institut für Mikrotechnik Mainz GmbH, Carl-Zeiss-Str. 18-20, D-55129 Mainz, GermanyTel: +49-6131-990323Fax: +49-6131-990205E-mail: kiesewalter@imm-mainz.de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Crisis, Religious Dissents and Female Knowledge in Early Modern Europe' under Sixth Framework.

assistant: **Concept**

The proposed study of early modern catholic reform movements sets out to investigate a cultural phenomenon that throughout Europe was shaped by female initiative. The goal is to examine the nexus of knowledge, power relations and female piety in early modern European societies.Moreover, by re-evaluating the role women held in mysticism around 1700 and asking for the reasons of the failure of this model of thought and behaviour, in a second step the study shall allow a new understanding of the gendered development of secularisation in European society. Employing gender as a category of analysis enables a reconsideration of the traditional understanding of the beginning of modernity.The analysis of the early modern renegotiation of gender roles will be under taken as a study of concrete circulation of cultural knowledge: the circulation of manuscripts and printed texts, tracing notices of particular publication strategies, travelling and meeting in devote circles, monasteries and at court.It will be carried out as a detailed case study of quietist circles, exploring the differences that characterized the development of the movement in urban, courtly and provincial environment and the analogies between the French, the Italian, the Spanish and the German development.The quietist movement was characterised by frequent exchanges across both territorial and confessional boundaries (analogies to pietism). The recent opening of the Archives of the Holy office and new sources now permit the separate and local branches to be interconnected and situated within the broader, European context.Furthermore, it will be possible to demonstrate what political issues were at stake. Engaging in interdisciplinary dialogues and through the comparisons between the cultural production of differe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Massive-Object Quantum Physics'.

assistant: **Innovation**

The world of quantum physics is usually associated with the microscopic cosmos of atoms and photons. In principle, but so far without any demonstration, even heavy objects can exhibit the distinguished properties of quantum world particles. In 1935, Einstein, Podolsky and Rosen (EPR) challenged a particular prediction of quantum theory saying that two particles can exist in a so-called entangled state in which the two particles do not have individually defined (‘local’) positions and momenta. Most interestingly, the existence of entangled states was subsequently fully confirmed in experiments with photons and atoms.The new project MassQ aims to test and to confirm quantum theory in the macroscopic world of massive, human-world sized objects by realizing an EPR entanglement experiment with heavy mirrors. Two kg-sized mirrors will be cooled to low temperature and their centre of mass motion driven by radiation pressure of intense laser light in such a way that the mirrors will lose their individually defined positions and momenta. As a result, their joint motion will form a unified massive quantum object.This project will realize a fundamental test of quantum theory in the so far unexplored regime of human-world sized objects. Recent advances in gravitational wave detector research and in opto-mechanics make this project feasible. The vision of this project points even further into the future. This project aims to lay the basis for a completely new class of physics experiments. Mirrors with kilogram masses have a proper gravitational field and cause a space-time curvature in their vicinity. This way, in principle, the dynamics of two heavy entangled mirrors need to be described not only by quantum theory but also by general relativity. Today it is completely unclear what
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Spatial Heterogeneity of Resources: a mediator of large herbivore population stability?' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The overall objective of SPHERE is to explore the role of spatial heterogeneity of resources as a mediator of large herbivore population stability in African savannas. Recent studies predict that the increased variability in rainfall that is predicted under local climate change scenarios and the resulting temporal variability in resource availability will lead to severe declines in African herbivore populations. However, new theory predicts that spatial heterogeneity of resources can act as a buffer against such temporal heterogeneity. Up to now this theory awaits empirical testing. African savanna grasslands are an ideal system to test this theory, with characteristic grazing lawns as a clearly visible aspect of spatial resource heterogeneity. Several grazer species concentrate foraging in these lawns but it is unclear how lawn abundance and spatial distribution affects grazer population dynamics on a larger scale. SPHERE will use this system to investigate the hypothesized effect of resource heterogeneity on population stability. Moreover, SPHERE will advance current theory by including inter-specific differences, specifically body mass and digestive physiology. Both strongly influence herbivore resource requirement. Finally, it will link population-level responses to demographic processes by testing how resource heterogeneity affects survival of different age-classes. To this end SPHERE will quantify lawn distribution in two South-African reserves and relate it to spatially explicit demographic and long-term census data of six herbivore species that differ in body mass and digestive system. The fellow will be based at the Centre for Ecological and Evolutionary Synthesis (CEES), University of Oslo. CEES will provide the candidate with excellent training opportunities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'TELE TEACHING AND TRAINING FOR MANAGEMENT OF SMES' (TELEMAN), addressing dissemination and exploitation.

assistant: **Impact**

TELEMAN is a study which aims to discover the requirements and opportunities for the creation of a European wide telematic infrastructure facilitating a teleteaching and training 'package' for management of SMEs. TELEMAN will analyse the cost/benefit of offering a tele-training package and service for SMEs. The study will analyse the tele-training trends and use in industry (focused on SMEs). This will be achieved by surveying some 5,000 European SMEs. A more in-depth analysis will be carried out of 50 'typical' cases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'How to best meet the needs of people with dementia with severe behavioural disturbances. Toward a respectful and cost-effective model'.

assistant: **Concept**

The RECAGE project will tackle one of the most challenging problem arising during the clinical course of dementia: the so-called Behavioural and Psychological Symptoms of Dementia (BPSD). The current state-of-the-art of the treatment of these symptoms is still unsatisfactory and there are many unmet needs in this area. The major objective of the project will be to assess the effectiveness of an intervention, the special medical care unit for patients with BPSD (SCU-B), that, albeit already implemented in some European countries, is not widespread and has not been sufficiently studied so far, although it seems to be promising for its short-term efficacy (alleviating BPSD and improving quality of life of PwD) and possibly for its long term efficacy.In order to achieve this goal, RECAGE will proceed in three steps:1) A prospective cohort study, comparing the activity of the centres endowed with a typical SCU-B with that of the other participating centres lacking this facility; the efficacy and the cost-effectiveness of the proposed intervention will be tested in the prospective study. The expected benefits are socially appreciable: improving quality of life of persons with dementia, lessening caregivers' burden, possibly delaying institutionalisation2) A conference aiming at adapting the SCU-B model in accordance with the results of the cohort study, not only regarding its main endpoints, but also comparing the experience and the different ways of operating of the participating centres and the different socio-political context in which they act3) A plan for scaling up the intervention in the countries who take part in the study, but where SCU-Bs are absent or sporadic as Italy and Greece.


**Keywords:** Dementia, Behavioural and Psychological Symptoms of Dementia, Special
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Modelling, Simulation and Control of Nonsmooth Dynamical Systems' to be submitted under Fifth Framework.

assistant: **Abstract**

The purpose of this grant is to develop algorithms and software for the simulation and feedback control of dynamical systems which are nonsmooth, and more specifically so-called Complementarity Dynamical Systems. The research will tackle head on two fundamental fields of research and applications in this area. First that smooth numerical methods fail on nonsmooth complementarity systems. Algorithms need to be developed that deal with hit crossings, impacts, complementarity problems, sliding and chatter in a robust and applicable way. Second, the qualitative understanding of the dynamics including the design of feedback and robust control algorithms requires specific methods and cannot be solved with simple adaptations of known techniques for smooth linear or nonlinear dynamical systems.OBJECTIVESThe strategic aim of this project is the development of novel algorithms and numerical routines for the qualitative analysis, simulation and feedback control of nonsmooth complementarity dynamical systems. The output of this project will be an integrated numerical software package for the virtual prototyping of systems with discontinuities and development of novel control techniques for this class of dynamical systems. This will be achieved through an in-depth investigation of the mathematical and engineering open problems related to nonsmooth complementarily systems. Therefore, this project is clearly focused on the development over 4 years of a user friendly, versatile and computational.DESCRIPTION OF WORKThe proposed research needed to achieve the objectives of the project will proceed in 7 concurrent workpackages reflecting the fact that, a lot of detail work has to be performed integrating existing results with new derivations to overcome the existing restrictions. In parti