RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Topological Josephson devices as a novel platform for creating and controlling non-Abelian anyons' (TOPOTRONICS).

assistant: **Concept**

Surprisingly, in two-dimensional systems quasi-particles may exist that are neither fermions nor bosons. When these particles are interchanged, their joint quantum mechanical wave function is predicted to pick up any phase in between 0 (as for bosons) and pi (as for fermions), hence the name anyons.Even more intriguing is the class of non-Abelian anyons where interchange of particles completely changes the ground state of the system. This phenomenon lays at the heart of a wealth of theoretical proposals for new types of quantum statistics and topological quantum computation that is robust against decoherence. While theory has well advanced, experimental realizations possess their own challenges and are seriously lacking behind.It is the objective of this proposal to experimentally realize a platform to detect and control non-Abelian anyons. We propose to combine the particle-hole symmetry of a superconductor with the spin-momentum locking at the surface of a topological insulator. Topological Josephson junctions are predicted to host Majorana type bound states at vortices. We propose to artificially create Josephson vortices at the junction of three phase-biased superconducting islands and to control and braid multiple Majorana states to prove their non-Abelian anyon character.In preliminary experiments we have shown, as one of the first groups in the world, to be able to induce superconductivity in a topological insulator by the proximity effect. This puts our group in a unique position to open up the field of topological Josephson physics. The great technological challenges of the present proposal lay in the development of topological insulator materials with higher surface mobility and their integration into Josephson electronic circuitry with multiple phase biased s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mcav' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The object of this proposal is the organization of a conference on the topic of modular curves and modular abelian varieties. This topic belongs to Number Theory, one of the oldest areas in Mathematics, and has been an important source of research for the last few decades. Many of the most important results in Number Theory and Arithmetic Geometry of the last years have some relation with modular curves and modular abelian varieties; for instance the determination of the rational torsion of elliptic curves by Mazur or the proof of Fermat's Last Theorem by Wiles (after work by Frey, Ribet, Mazur, Serre, Taylor and others).The development of computer technology influenced the work of mathematicians and nowadays many computational aspects of modular forms and modular curves are being investigated with the help of computers. Moreover, modular curves and abelian varieties have applications to communication technologies, since they can be used to develop good error correcting codes and digital signature algorithms. The objective of the Conference is to present the latest developments by some of the top researchers on the subject, that will discuss both theoretical and computational results, along with applications. The Conference will be an occasion of contact between research teams working in many European and non-European countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Deciphering SNPs involved in oligodendroglia functional resilience in multiple sclerosis' (ResilMS).

assistant: **Innovation**

Multiple sclerosis (MS) is a prevalent demyelinating disease that primarily affects young adults. Current therapy for MS mainly focuses on immune suppression and alleviating inflammation. However, efforts to promote remyelination face challenges in clinical translation. Animal models of acute demyelination have demonstrated promising remyelination, primarily facilitated by newly generated oligodendrocytes. Nevertheless, the scenario in human MS differs, as the disease typically manifests in adulthood and the progression of lesions occurs over several decades. In the proposed project ResilMS, by using barcode based lineage tracing combined with ultra-depth single-cell and spatial transcriptomics, I will identify the molecular profiles of existing and newly generated oligodendrocytes at different stages of a mouse model induced with experimental autoimmune encephalomyelitis (EAE). The aim is to comprehend how an oligodendroglial cell pool diversifies its subpopulations during prolonged disease challenge, and what are the unique molecular properties for resilient cells to maintain their ability to endure an adverse inflammatory environment and remyelinate. Further, I will perform a screen of single nucleotide polymorphisms (SNPs) associated with risk and severity of MS that might affect genes related to the resilience of oligodendrocytes. To experimentally explore the effect of relevant SNPs, human oligodendrocyte cells (hOLGs) derived from pluripotent cells will be perturbed with CRISPR-based genetic modification and observed for cell profile and functional changes.The identified SNPs and resilience molecular pathways may play a critical role in disease progression for MS patients. By delving into the mechanisms of resilience of (re)myelinating cells in a long disease cou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Theoretical design of non-fullerene small molecule acceptors for organic solar cells with improved efficiency.' under Horizon 2020.

assistant: **Concept**

Organic solar cells are lightweight, mechanically flexible and potentially printable devices. To split an exciton, these cells use a mixture of electron donor and acceptor materials. At present, most of the electron acceptors are made up of fullerenes or their derivatives. However, fullerenes exhibit only weak light absorption in the visible spectrum. Hence, practically half of the active material in the solar cell does not collect light and thus does not contribute to exciton and charge generation, thereby limiting the maximum efficiency of organic solar cells to 12%. Recent experimental and theoretical works show that it is possible to improve this low efficiency by replacing fullerene acceptors with small molecules (strong dyes). These strong dyes can change the energy profile of the donor-acceptor interface in a way that improves the solar cell behavior by causing it to favor more efficient charge-transferred state splitting. The mechanism by which the efficiency is improved is complex and not well-understood and is mediated by the strong dye’s ability to alter the electrostatic forces felt by generated excitons. However, a rational approach to design such non-fullerene acceptors on a molecular level, accounting for the complex electrostatic interactions, has not been developed.In-depth molecular level understanding of donor-(non-fullerene) acceptor interfaces, including long-range electrostatic effects, is the first goal of this proposal. It will include simulations of morphologies and evaluation of electrostatic forces at donor-non-fullerene acceptor interfaces for several experimentally well-characterized systems. The second step will include the design of a pre-screening workflow for new acceptors, focusing on the optimization of the efficiency of the charge-tra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'La-icp-ms analysis of trace elements in biogenic minerals - time series recording of environmental changes' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content The project will contribute to our understanding of trace element behaviour in biogenic minerals via LA-ICP-MS analysis. Study objectswill be bivalve shells and fish otoliths. Focus will be on relative importance of physiological vs environmental control. The impact  of changes in such environmental parameters as temperature, salinity, trace metal pollutants will be assessed by studying the variability of the most appropriate elemental tracers. Short and long-term environmental variations, will be assessed via the study of biogenic minerals with different growth rates. Training content (objective, benefit and expected impact) The applicant will acquire expertise in the use of a powerful analytical tool for the determination of trace elements through discrete point analysis directly on the specimen. This technology can be applied to a wide range of biological, geological, and other materials. The acquisition of such expertise by research units in the area of origin of the applicant complies with needs expressed by local collectivities and industries and is thus likely to open career opportunities. Links with industry / industrial relevance (22) Fishing, oyster, fish, and clam nurseries represent the basis of the economy along the Atlantic coast of southern France Accordingly, mixed CNRS-IFREMER research units, integrated in EC-programmes, are developing projects to improve qualitatively and quantitatively the resources. The acquired expertise will eventually be used locally, but cab be of interest anywhere else.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a cost-effective and sustainable insecticide-free plant protection method, eliminating widespread catastrophic damage in the forestry caused by the pine weevil Hylobius abietis' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The WeevilSTOP project will significantly increase competitiveness and sustainability for the large number of SMEs in the European Forestry and Forest-based Industries. About 16 million Private Forest Owners manage 60% of Europe’s forest, generating 3 million jobs and create a total turnover of €300Bn annually.Our community has a great and urgent need for innovation in order to substitute currently used insecticides that are banded by new EU Regulations and by certification bodies due to health and environmental issues. To prevent a huge economical loss in the range of annually €140 M in EU-27 for the forestry sector, we need alternative insecticide-free plant protection methods.Our idea is to develop a cost-effective and sustainable insecticide-free pest management method for young forest trees that is even more effective than insecticides. We propose to create innovative technology for environment-friendly, toxicologically safe, and sustainable pest management of one of the most destructive pests in tree planting and re-forestation of conifer forests – the pine weevil Hylobius abietis.We will achieve this by 1) using a refined wax formulation, which mechanically protects the stem bark from feeding damages inflicted by the adult pine weevil; 2) developing a new Waxing System that precisely coats the main stem of conifer seedlings with wax, and 3) developing a new Pick-and-Place System to handle all kinds of containerized grown spruce seedlings.Our innovation will prevent the private forest owners from an economical loss of annually €140 M in EU-27. Moreover, the private forest owners will benefit from substantial savings in costs for pest management, increased revenues from up to 8% higher wood production resulting from 10% lower seedlings mortality rate, and new marke
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Beta-cell function in juvenile diabetes and obesity' to be submitted under Seventh Framework.

assistant: **Abstract**

The number of individuals with obesity and type 2 diabetes mellitus (T2DM) is increasing. An alarming aspect is decline in age of onset of T2DM, which is coupled to rise in childhood obesity. Accentuated insulin secretion is observed early in young obese individuals. In many subjects insulin hypersecretion is evident when insulin sensitivity is essentially normal. Based on these observations we propose insulin hypersecretion as an etiological factor promoting lipid deposition, insulin resistance, cellular dysfunction and death in insulin-producing beta-cells and insulin-target brown adipocytes. Pharmacology-based treatment strategies are limited for this growing patient group and the aim of the proposal is to identify novel strategies reducing insulin hypersecretion, which has not been considered a target for intervention in young obese individuals. To address the issue, pediatric obesity clinics and academic centres with focus on beta-cell biology, brown adipocyte imaging, transcript and protein profiling, genetics, epidemiology and bioinfomatics have formed a consortium with two SMEs specialized on biomarker discovery and clinical trials and one large drug company. In the project well-characterized European patient cohorts of more than 3000 obese children will be further characterized with regard to insulin secretion and brown adipocyte mass. Currently used drugs and new principles of intervention based on novel genes, idenitifed in the project and linked with insulin hypersecretion, will be examined for effects on insulin hypersecretion in translational work including the young obese subjects and isolated human islets. Following comprehensive analysis candidate compounds/principles attenuating insulin hypersecretion will be selected, from which novel therapeutic stra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Towards systematization of NNLO theoretical predictions foradvanced phenomenology at the LHC', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The physics program of the Large Hadron Collider at CERN will help us answer some of the most fundamental unresolved questions in physics. Any verification of present knowledge or solid proof of new physics will only come after copious efforts of comparing experimental data against accurate theoretical predictions. For most of the processes at the LHC, calculating perturbative corrections in quantum field theory at the next-to-leading order (NLO) is sufficient whereas for some processes next-to-next-to-leading order theoretical predictions (NNLO) are needed, a highly non trivial theoretical task. We propose to apply a novel technique, the Duality Relation between loop Feynman integrals and phase-space integrals, to the study of W pair + jet production to NNLO at the LHC, an important process and currently beyond the state-of-the-art. Secondly, we propose to create a public library with the results of all the two-loop Feynman integrals necessary for some of the most important LHC processes that are needed to NNLO. Our two objectives are complementary and we expect that they will help towards the development of new NNLO partonic Monte Carlo event generators in our field. If the Duality Relation approach to phenomenological studies proves to be an optimal choice, as we believe, we will manage to succeed in having a unified treatment of the real and virtual radiation amplitudes paving the path towards the systematization of the LHC phenomenology to NNLO.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'SET-Plan Conference 2019 Helsinki' to be submitted under Horizon 2020.

assistant: **Abstract**

This proposal addresses the Work Programme 2018-2020 for Secure, Clean and Efficient Energy. In particular it addresses section “Support to the Finnish Presidency Conference on the European Strategic Technology Plan (SET-Plan) 2019” of the chapter “Transforming the Energy Sector Through Digitalisation” subchapter “Grants to Identified Beneficiaries”.The European Strategic Energy Technology Plan (SET-Plan) was established to accelerate the transformation of the European energy system and to bring new low-carbon energy technologies to market. It identifies actions for research and innovation throughout the whole innovation chain. SET-Plan conferences offer an opportunity for decision-makers, researchers and stakeholders to get together and evaluate the progress made towards achieving the SET-Plan’s goals.The 13th SET-Plan Conference will take place on 13-15 November 2019 in Helsinki, Finland. The conference venue is the conference wing of the Finlandia Hall. The organisers of the conference are Ministry of Economic Affairs and Employment of Finland  (TEM), the Prime Minister’s Office of Finland (VNK), VTT Technical Research Centre of Finland Ltd (VTT) and the European Commission.


**Keywords:** SET-Plan,  energy technology,  clean energy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bioinfo 2001 - 2002' (1998-2002).

assistant: **Concept**

Bioinformatics provides the key to the interpretation and exploration of massive amounts of data stemming from various genome projects. It requires an interdisciplinary and collaborative effort to cope with the needs of the present and future genome based research. Training young researchers in this field makes it necessary to present a broad spectrum of topics. This spectrum covers sequence and structure data analysis and includes such diverse areas as expression analysis, proteomics, comparative and functional genomics, metaboic and functional networks, algorithmic and complexity, knowledge presentation and data mining.A European effort to develop training programmes in the fled of genetics requires a strong support for bioinformatics and the availability of training structures where both students and Faculty members will exchange ideas and strategies to be integrated into an inter-disciplinary background. While at present bioinformaticians represent an indispensable human resource for biomedical research, whose training has to be strongly promoted in Europe, at the same time biologists, biochemists and physicians must learn to apply bioinformatics as a problem-solving tool. In order to help filling this gap, the EGF proposes a training course specifically aimed at bioinformatics. The traditional format of the scientific and training activities developed over the years in Sestri Levante consists of plenary lectures that are given during the morning and concurrent workshops during the afternoon. These are interactive group discussions between 10-15 students and one-two faculty members on a specialized topic of research.There are two rounds of 6-7 concurrent workshops every afternoon and faculty are asked to give, in addition to one lecture in a plenary session, one or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Computational, Chemical and Biotechnology Solutions to Improved DNA Data Storage: from In-Product Information and Cryptography to Long-Term Archiving', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Modern information-based society largely relies on trusted information storage in a large variety of setups, ranging from long-term digital archiving to embedding information into products. DNA is a promising future storage medium for such diverse applications as it offers sustainable and robust long-term information storage at extraordinary information density. DNA will also never become obsolete. However, long-term DNA archival storage is still very expensive. In DiDAX, we will develop new approaches to DNA storage based on novel encoding and decoding algorithms, new reduced cost synthesis approaches and new embedding technologies. Specifically, we will provide (i) synthesis, encoding and decoding methods for efficient reduced cost archiving using standard and composite DNA, (ii) in-product information storage technologies, including encapsulation and embedding, as well as tailored coding and reconstruction approaches, (iii)  methods for efficient labeling and cryptographic authentication, and (iv) efficient and new approaches to photolithography-based synthesis and composite synthesis of DNA, to enable reduced-cost DNA storage. We will demonstrate end-to-end PoC systems for reduced-cost archival storage, in-product information storage as well as DNA-based authentication protocols. The DiDAX project will expand the long-term applicability of archival DNA-based data storage through significant improvements in cost. Furthermore, DiDAX will broaden the range of DNA-based information technologies and lead to applications realizable in the short term by developing in-product information storage solutions and DNA-based authentication protocols. DiDAX methodology is highly interdisciplinary building on expertise in computer science, engineering, chemistry, material science,