RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'PRODUCTION OF PHYCOCYANIN FROM THE SPIRULINA ARTHROSPIRA SP. REVISITING THE SOURCING, EXTRACTION AND CO-VALORIZATION OF THE WHOLE ALGAE IN THE FRAME OF AN INDUSTRIAL BIOREFINERY CONCEPT' (SpiralG) targeting Horizon 2020.

assistant: **Abstract**

The actual demand for phycocyanin is tremendous, especially in the food industry where it is used as a natural food colorant. With a world demand of over 100 metric tons, the global market is expected to continue to grow. As proof of this potential, world leaders in that field are investing several million dollars in production lines. Being authorized under the American Food and Drug administration since 2013, its production remains very artisanal worldwide and important amelioration possibilities exist at several levels.This project aims to build a demonstration plant with a progressive production capacity of 10MT of phycocyanin per year. Successful demonstration is critical in order to ensure a swift transition towards an industrial capacity. For this project, the partners (GREENSEA, MILIS, ALGAIA AND MIAL) have concluded a strategic industrial partnership with the ambition to revisit the sourcing, extraction and co-valorization of the whole algae in the frame of an industrial biorefinery concept and a business model strategy. In complement, UCD will be in charge of the Life Cycle Assessment, to undertake a comprehensive sustainability evaluation of the project.Partners will work over 48 months to find ways to innovate in their own field but always working with a collaborative objective to build a more efficient bio-based full value chain with stable products and valorization of co-products. The consortium gathers all the expertise and an economic analysis will be made as well as a life cycle assessment. A communication and dissemination plan is already established. This project will increase the competitiveness of European biomass producers and industry by supporting new jobs, growth and investment while ensuring environmental sustainability and a low environmental i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Widely Tunable Soliton Microcomb Chip' (ELASTIC) targeting Horizon Europe.

assistant: **Abstract**

The generation of optical frequency combs through nonlinear optical processes is an enabling technology for a wide range of applications. These combs, consisting of equally spaced coherent light frequencies, are highly valued in applications such as communications, LiDAR, and microwave photonics. The first generation of combs, developed using mode-locked lasers, expanded their spectrum through nonlinear media to create broadband frequency combs. Initially, these systems relied on bulky free-space optical components. Efforts to reduce the size, weight, and power (SWaP) of these systems led to the development of microcomb technology. Dissipative Kerr soliton (DKS) microcombsgenerated via nonlinear optical processes in microresonatorshave emerged as a more compact, scalable, chip-based alternative, offering higher repetition rates, lower power consumption, and simplified broadband spectrum generation and attracting significant market interest. Despite their advantages, DKS microcombs face several bottlenecks, including limited tunability, sensitivity, and poor conversion efficiency. The ELASTIC project aims to address these issues by leveraging the high thermo-optic coefficient and nonlinearity of the AlGaAsOI platform combined with a novel pump scheme. This approach will enable low-power, highly tunable, and insensitive chip-scale comb systems for emerging applications like massively parallel frequency-modulated continuous-wave LiDAR and wavelength-division multiplexing systems.


**Keywords:** Integrated Optics, Microresonators, Soliton Microcombs, Kerr frequency combs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advanced material for the regeneration of joints in veterinary medicine' (VETBIOMAT) targeting Horizon 2020.

assistant: **Abstract**

The main objective of VetBiomat is to undertake a technical and market feasibility study on an innovative regenerative medicine treatment for osteoarthritis (OA) in horses and dogs based on a new advanced material, HR007. The use of this material is expected to significantly increase treatment efficiency over currently marketed products and address the unmet need of achieving a cure for this disease in horses and dogs.Osteoarthritis, a progressive deterioration of the joint cartilage, is a major economic problem in veterinary medicine. Currently, there is no cure for OA, and therapies available rely on reducing symptoms (corticosteroids, NSAIDs, and analgesics) or on the administration of glycosaminoglycans by different routes. No sound scientific evidence of efficacy for most glycosaminoglycans based commercial treatments has yet been obtained, especially when administered orally, nutraceuticals, which actually have the largest market share. Therefore, the market potential for a new efficacious, complex, and regenerative intra-articular product of non-bovine origin is very large.ArtinVet Innovative Therapies, S.L., a new SME specialized in veterinary regenerative medicine, has a novel and unique multiple GAGs rich material of natural origin, HR007, for inclusion in new regenerative medicine based products for veterinary medicine. This advanced material has shown in vitro superior qualities to any other tested products in promoting cartilage regeneration and chondrocytes and mesenchymal cells migration. HR007 production has been standardized and industrialized. Successful completion of Phase 1 of VetBiomat will yield a robust business plan for a much larger project that will seek funding under Phase 2 of the SEM Instrument, when clinical studies and product authorizatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A bio-mimicry enabled artificial sniffer' to be submitted under Seventh Framework.

assistant: **Abstract**

The capture and analysis of odours offers significant potential for border security applications related to the detection and analysis of persons, illegal substances and in particular explosives. Dogs - the most effective ""tool"" for detecting and analysing odours - can only be trained for a small sample of odours, get easily tired and are often perceived as intrusive by the public.The SNIFFER project proposes a highly innovative one-stop shop approach to complement dogs and leverage their capabilities. This approach is based on state-of-the-art technologies centred on a new generation of olfactory biosensors. The SNIFFER devices to be developed combine in a one-stop shop sampling, pre-concentration and pre-treatment with bio-mimicry, synthetic diamond sensor technology and multi-parametric training software. This will enable the detection of odours arising out of security threats which may occur in a panel of border security applications. This flexible technology allows users to continuously keep improving the ""olfactory scope"" of their ""artificial sniffers"" quickly and at low additional cost, even once they have been deployed.This concept results from a multidisciplinary collaboration of several years between research teams from Italy, the UK, France and Switzerland. Users involved in the SNIFFER project will provide a representative set of usage cases, all related to border control security in the large sense - such as the detection of illegal substances carried by people and in suitcases (open or on a luggage belt) and cars or the detection of hidden people in containers. EADS, the integrator partner will build dedicated systems for these usage cases to allow for a comprehensive assessment in view of progressively improving the technology. The project will henc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'An Intelligent Interactive Services Environment for Assisted Living at Home' (INHOME) under Sixth Framework.

assistant: **Objectives**

The goal of the INHOME project is to provide the means for improving the quality of life of elderly people at home, by developing generic technologies for managing their domestic ambient environment, comprised of white goods, entertainment equipment and home automation systems with the aim to increase their autonomy and safety. Contrary to the practises followed up to now, the INHOME project focuses on the problem of appliances flexible use by discriminating between experienced and inexperienced rather than enabled or disabled users. By adopting this radically different standpoint the project is posed to set out a generic set of appliance design guidelines targeting the intensification of home appliances use and user dependency. In accordance with this concept, the INHOME project aims at furnishing its offerings through the establishment of the four-tier architecture. The bottom line technology is offered by the ESTIA project (IST-FP6-4-27191), which focuses on the design and development of technologies for efficient personalised management of audiovisual content and white goods functions, locally within the home.  INHOME will utilise ESTIA architecture in order to design and develop a set of services for aged people, which will be delivered in the form of the following showcases with the aim to enhance their autonomy and safety at home: ·Activity Monitoring ·Home Environment Simple Management ·Tasks scheduling ·Flexible AV streams handling ·Household appliances flexible access The consortium includes four Europe-wide leaders in telecommunications, IT and household appliances systems manufacturing (ALCATEL, THALES, SIEMENS, GORENJE), three SME systems development companies (TELETEL, THOSS, VMWS) with significant know-how in communication protocols and services in the te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'HyperCube: Gram scale production of ferrite nanocubes and thermo-responsive polymer coated nanocubes for medical applications and further exploitation in other hyperthermia fields' (HyperCube).

assistant: **Concept**

This project aims at the scale up production, characterization, future commercialization and clinical translation of magnetic iron oxides nanocubes of high magnetic and structural quality and the design and production of an in-flow set up for the further functionalization of the nanocubes with a thermo-responsive (TR) polymer shell. The nanocubes and TR-nanocubes are aimed to be used primarily as heat mediators in magnetic hyperthermia (MH) and as heat-mediated drug agents for the delivery of chemotherapeutic drugs in a heat triggered-mediated chemotherapy for the treatment of tumors. Their use as contrast agents in magnetic resonance imaging (MRI) and magnetic particle imaging (MPI) stands as secondary applications  and it will also be relevant in this project. Indeed, given the control over the materials, the scale up synthesis of nanocubes and the in-flow production of TR-nanocubes, we will deliver an unprecedented benchmark scaled product of nanocubes with optimal magneto-heat properties that shall ensure the transition of such materials towards the market and the clinics. In comparison to the standardly used and commercially available magnetic nanoparticles, the high magneto-heat performances at clinically safe magnetic radiofrequency, of such nanocubes will impact the treatment of tumor by MH, by multiple aspects: i) requiring less dose of magnetic materials to be injected intratumorally; ii) unique actuation of dual combination therapy of MH and local heat-triggered drug release, which also will favor a more efficacious therapy at reduced dose of magnetic materials; iii)  further degradation and clearance of the heat-mediator nanocubes thus enabling the further investigation of tumour progression by MRI, overcoming the current limitation of iron oxide nanoparticl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'First In class oliGo THerapy for Myotonic Dystrophy type 1 (DM1)'.

assistant: **Objectives**

Myotonic dystrophy type 1 (DM1) is a clinically and genetically heterogeneous disorder with more than 1 million diagnosed patients worldwide, making it the most common adult muscular dystrophy. Available treatments only relief symptoms. Given this need, we offer ATX-01, a first in class miRNA therapy that inhibits miR-23b without changing the DNA, which rescues DM1 pathogenic mis-splicing. We have demonstrated improved target engagement effects in skeletal and respiratory muscle in in-vitro and in-vivo studies, granting us an FDA pre-IND approval and orphan drug designation. Our approach, antimiRs conjugated to fatty acids, constitutes the ENTRY platform, which guarantees efficient drug delivery to target muscular and extra-muscular tissue at low doses. This patented technology will be validated through a Phase I/IIa clinical trial and chronic preclinical studies, to then be extended to applications as other myotonic dystrophies, Fuchs dystrophy, cachexia, among other opportunities.


**Keywords:** Antisense Oligonucleotide,microRNA,RNA Therapy,Myotonic Dystrophy type 1,Biotechnology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'G-protein-coupled receptor kinases (GRKS) and arrestins in cardiovascular function and disease' (GRKS) targeting Fourth Framework.

assistant: **Abstract**

G protein-coupled receptors (GPCR) mediate the action of messengers, which are key modulators of the function, growth and differentiation of cardiac and vascular cells. Alpha and beta adrenergic, angiotensin or endothelin receptors are major targets of pharmaceutical compounds very frequently used in the management of chronic heart failure, angina pectoris or hypertension, which are leading health problems in the European Union. G protein-coupled receptor kinases (GRKs) and arrest in proteins are critical components of the regulatory network which modulates the function of GPCR and triggers receptor desensitisation (=loss of function) upon agonist stimulation. Such important role suggest that changes in the expression or function of GRKs and arrestins may affect the efficacy of signal transduction systems and underlie pathophysiological processes. In fact, marked desensitisation of Beta-adrenergic receptors is a major mechanism in congestive heart failure, and an increased expression of the GRK2 isoform in the failing human heart has been recently reported by partners of this proposal, thus suggesting a potential role for alterations in these regulatory proteins as primary or early events in the development of heart failure.Other recent data obtained in transgenic models also suggest an essential role for this protein in regulating cardiac cell function, growth and differentiation. Alterations in GRKs and arrestins may also affect the function of GPCR systems other than Beta-adrenergic which are related to cardiovascular pathophysiology, as alpha1-adrenergic receptors or angiotensin II AT1 receptors, which mediate processes of cardiac and vascular hypertrophyand remodelling.In this context, the aim of this proposal is to elucidate the physiological and pathophysiologica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Embodied Honesty in Real World and Digital Interactions' under Horizon 2020.

assistant: **Concept**

Every day, everywhere, people make unethical choices ranging from minor selfish lies to massive frauds, with dramatic individual and societal costs. Embodied cognition theories posit that even seemingly abstract processes (like grammar) may be biased by the body-related signals used for building and maintaining self-consciousness, the fundamental experience of owning a body (ownership) and being the author of an action (agency), that is at the basis of self-other distinction. Applying this framework to morality, we hypothesize that strengthening or weakening participants’ bodily self-consciousness towards virtual avatars or real others will influence dishonesty in real, virtual, and web-based interactions.To test this hypothesis, we will measure:i) individual dishonesty after modifying body ownership (e.g., by changing the appearance of the virtual body) and agency (e.g., by changing the temporal synchrony between participant’s and avatar’s actions) over an avatar through which decisions are made;ii) intergroup dishonesty after inducing inter-individual sharing of body self-consciousness (e.g., blur self-other distinction via facial visuo-tactile stimulation);iii) individual and intergroup dishonesty by manipulating exteroceptive (e.g., the external features of a virtual body) or interoceptive (e.g., changing the degree of synchronicity between participant’s and avatar/real person’s breathing rhythm) bodily inputs.Dishonesty will be assessed through novel ecological tasks based on virtual reality and web-based interactions. Behavioural (e.g., subjective reports, kinematics), autonomic (e.g., heartbeat, thermal imaging) and brain (e.g., EEG, TMS, lesion analyses) measures of dishonesty will be recorded in healthy and clinical populations.Our person-based, embodied approa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'An Improved Thermal Spray Process Which Incorporates an IntelligentShroud System' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Protective coatings produced by thermal spraying processes comprise an area of great economic importance which cuts across most sectors of the European industry. The components protected include those suffering from corrosion and erosion in the power, petrochemical, gas, aerospace and construction industries. At present the Arc Wire Spraying process which insure the highest deposition rate (up to 40 kg per hour) has poor oxide and porosity levels (cumulatively greater than 25%); besides the Vacuum Plasma Spray process which guarantees coatings with low oxide levels (less than 5%) is very expensive both in terms of the capital (of order 1 MECU) and operating costs (very low production rates). There is a need, therefore, of cost effective spraying processes which can insure a very high deposition rate along with a good coating quality. The objective of this proposal is to develop wire and air plasma spraying processes with much higher quality (porosity less than 10% and oxides less than 5% for the air plasma spray and porosity and oxides less than 10% for arc wire) than present processes, with a potential of replacing vacuum plasma spraying in more demanding applications. In order to reach this objective both an innovative shroud design and an intelligent" control system will be developed. The shroud covering the outside of the spraying torch will provide shielding gases and avoid air entrainment to protect the spray stream from oxygen. The feed back control system will provide a self controlling or "intelligent" system, allowing to adjust the process parameters in order to maintain the torch and spray stream aligned on plasma and reduce stream divergence on wire systems. The effectiveness of the processes will be demonstrated by coating real components such as valves, tu