RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Smartcard with USB (Universal Serial Bus) interface' (1998-2002).

assistant: **Concept**

For comfortable and unhindered e-commerce activities the usual smartcards (as security tokens) are not an optimal solution. Their use requires the availability and use of an appropriate card reader. This results in debates regarding who has to pay for the reader (especially in broad, low cost use). Such a reader is uncomfortable in handling (at least for mobile use) and can obstruct a required serial connector on the PC already used for other devices, or the drivers cannot be loaded. Alternatively, modern information and communication equipment (like PC, Laptops or future mobile phones) have already a fast and easy to use USB connector with the according drivers an SW support. Goal of this proposal is to- add to an existing security smartcard chip a USB interface and the- adaptation of a typical e-commerce and a health care application.- execute a test with a major banking application- execute a test with a health care applicationThis shall reveal the path to how e-commerce can be much more widely be distributed.Objectives: For comfortable and unhindered e-commerce activities the usual smartcards (as security tokens) are not an optimal solution. Their use requires the availability and use of an appropriate card reader. This results in debates regarding who has to pay for the reader (especially in broad, low cost use). Such a reader is uncomfortable in handling (at least for mobile use) and can obstruct a required serial connector on the PC already used for other devices, or the drivers can not be loaded.Alternatively, modern information and communication equipment (like PC, Laptops or future mobile phones) have already a fast and easy to use USB connector with the according drivers an SW support.Goal of this proposal is to- add to an existing security smartcard chip a U
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dynamics of thought and thought disorders' in the context of a Horizon 2020 call.

assistant: **Objectives**

Psychiatric disorders are often characterized by maladaptive thought patterns. Whereas most research focuses on the distinct contents of maladaptive thoughts, abnormalities in the process by which thoughts come to mind are often overlooked. One exception is formal thought disorder (FTD), defined as a disruption in the form and organization of thought (e.g., loose associations). FTD is considered a hallmark feature of psychosis. Furthermore, recent evidence suggests that FTDs are found in other psychiatric disorders. Despite progress in the research of FTD in the recent decades, FTD remains one of the least understood symptoms in psychosis (all the more so in other disorders), with no established treatments. One key issue is that most FTD research focuses on language and communication impairments (e.g., disorganized speech), and not on actual thoughts. The overall aim of 'Dynamics of thought and thought disorders' (DynaT) is to dissociate impairments in thought dynamics from impairments in the communication or expression of thought, without relying on introspective self-report. To deal with the challenge of measuring covert thought, DynaT will use state-of-the-art computational psychiatry methods. First, DynaT will use mathematical modelling to gain insight into the covert thoughts preceding participants' observed responses. Second, DynaT wil use machine-learning algorithms to tap thought dynamics from the participant's brain activity in real-time. DynaT will isolate and characterise several component processes of FTD in schizophrenia and across the wider, transdiagnostic psychopathological spectrum, including: a) semantic disorganization; b) impaired inhibitory control of thoughts; c) inflexible reliance on predominant, local associations. As the first investigation to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CRYo-banking of Stem cells for human therapeutic application' under Sixth Framework.

assistant: **Concept**

Stem cells are at the centre of biomedical research. The development of human stem cell therapies will have to build on a safe and reliable supply of human stem cells which must be assured by cell banking. Currently, the isolation, identification and culture of stem cells are not standardised between laboratories, and reproducibility of protocols is limited. Today's banking approaches still rely on storing sources of stem cells rather than on banking of defined, well-characterised stem cell populations (both adult and embryonic). Cryopreservation of stem cells itself is not yet optimised and validated for the different cell types, and multiple cell biological and biophysical challenges remain to be addressed in order to define optimised cryopreservation protocols.  The problems currently limiting the routine application of stem cell banking with a therapeutic perspective will be addressed by the CRYSTAL project. The consortium will develop tools and optimised procedures to enable cryopreservation of different stem cell types and allow safe production of sufficient numbers of high-quality cells for future human therapy. This will comprise standardised protocols and tools for stem cell isolation, identification and culture, novel approaches to their cryopreservation (e.g. novel cryoprotectants, freezing in different conformations) and an automated quality control system for stem cell preparations.  Five stem cell research laboratories providing four different sources of adult (from cord blood, bone marrow and placenta) and human embryonic stem cells have teamed with two partners specialising in applied banking and fundamental cryobiological research. CRYSTAL is thus in a position to solve existing problems in an integrated, systematic approach and to provide standardised,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Effective Multidrug Cocktails for Cancer', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Cancer is a global epidemic that affects all ages and socio-economic groups. In turn, tremendous resources are being invested in prevention, diagnosis, and treatment of cancer. For instance, over 1,000 anticancer drugs are currently in various phases of development and pre-approval testing, more than the number for heart disease, stroke, and mental illness combined. Finding multi-drug combinations for cancer is an increasingly pressing therapeutic challenge. However, screening all possible drug combinations is an impossible task because the number of experiments grows exponentially with the number of different drugs and doses. Therefore, highly effective combinations of already approved drugs may likely exist that have never been tested before at the appropriate doses, due the astronomical number of wet lab tests required to find these combinations. Motivated by this challenge, we have developed a novel method for computing the effects of high order combinations of drugs on cancer cells and predicting the best drug for a given tumor based only on a very small number of experiments. In turn, the goals of our PoC project are to further validate the potential of our formula by means of numerous rigorous tests and to establish the business potential of our idea. If successful, this PoC project will pave the way to the development and adoption of highly personalized drug cocktails that are designed based only on a limited number of measurements performed on patient-derived tumor material.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Protein Translocation Through Bacterial Syringes' in the context of a Seventh Framework call.

assistant: **Objectives**

The main objective of this application is to study the molecular basis of cellular infection by bacterial ABC-type toxins (Tc). Tc complexes are important virulence factors of a range of bacteria, including Photorhabdus luminescens and Yersinia pseudotuberculosis that infect insects and humans. Belonging to the class of pore-forming toxins, tripartite Tc complexes perforate the host membrane by forming channels that translocate toxic enzymes into the host.In our previous cryo-EM work on the P. luminescens Tc complex we discovered that Tcs use a special syringe-like device for cell entry. Building on these results, we now intend to unravel the molecular mechanism through which this unusual and complicated injection system allows membrane permeation and protein translocation. We will use a hybrid approach, including biochemical reconstitution, structural analysis by cryo-EM and X-ray crystallography, fluorescence-based assays and site-directed mutagenesis to provide a comprehensive description of the molecular mechanism of infection at an unprecedented level of molecular detail.Our results will be paradigmatic for understanding the mechanism of action of ABC-type toxins and will shed new light on the interactions of bacterial pathogens with their hosts.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'BE-LIGHT Improving BiomEdical diagnosis through LIGHT-based technologies and machine learning' (BE-LIGHT).

assistant: **Concept**

Photonics is crucial for maintaining and increasing the competitiveness of EU industry, and light-based instruments are fundamental for non-invasive diagnostics and treatment of diseases, delivering huge economic benefits for national health systems. Artificial Intelligence (AI) and Machine Learning (ML) have demonstrated their capability to classify and identify patterns in data, achieving reliability levels that are comparable to those of experienced physicians. To fully develop the potentials of these technologies, BE-LIGHT will provide top level training to 11 Researchers in photonic technologies (multispectral imaging, eye-tracking, optical coherence tomography, multispectral optoacoustic tomography, super-resolution microscopy and optogenetics) that will be complemented with AI/ML, computational imaging and modelling. A close-to-the-clinic approach will allow them to advance the field of biomedicine, with the ultimate goal of improving the understanding, diagnosis and treatment of diseases in 3 main research areas: visual health, cardiovascular health, and analysis of cells and tissues (related to Parkinson’s and rare diseases) using super-resolution microscopy.BE-LIGHT brings together an interdisciplinary consortium of 7 top academic institutions, 3 internationally recognized hospitals, and an ecosystem of 7 private companies with complementary know-how in photonics, microscopy, AI/ML, medical instruments and clinical research, to promote inter-sectoral synergies. BE-LIGHT’s multi-skill training program will provide the researchers with the complete set of skills that are nowadays key for their success in both academic and non-academic sectors. They will gain a broad understanding of how state-of-the-art light-based technologies work, a solid knowledge of ML and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Grassfibre raw material and grasspaper products for the retail, paper and packaging industry, helping to reduce plastic and textile pollution and CO2 emissions on a global scale'.

assistant: **Innovation**

With grassfibre Creapaper introduces a highly innovative, sustainable and cost-efficient alternative raw material for the European paper industry. About half of the 400 million tons paper produced worldwide every year are based on wood pulp. This consumes about 40% of the global industrial wood harvest. Moreover, transport and processing of the wood consume a lot of water, chemicals and energy. Costs and impact to nature are severe. Creapaper provides an unique solution to this problems by introducing grassfibres, produced by a novel patented mechanical process, as a new resource for the paper industry which is compatible to standard production equipment. Grasspaper products are free of noxious substances, printable and have a distinctive sustainable, yet premium appearance and up to 75% of CO2 emissions are saved. They are therefore very attractive for packaging and to replace single-use plastics. Several awards in the packaging industry and first orders from large, well-known brands confirm these USPs of grasspaper products. While Creapaper's customers are paper mills, also brand owners and retailers are addressed with own designs and mock ups. This increases the demand for grasspaper and grassfibres rapidly and will allow a fast scale-up in the European key markets. We started establishing grassfibre as the paper industry's third raw material source besides wood pulp and waste-paper. Creapaper installed a first grassfibre production centre. In the project we will modify and optimise the production process, as well as grasspaper and coating properties, to allow cost-efficient mass production of grasspaper products. As the next step of ecologocal packaging materials also adding to circular economy, 100% treeless grass-textile paper, unsing textile waste and grass is de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'An electronic drone pilot and cargo custodian for blood and medical courier services'.

assistant: **Objectives**

On a daily basis, urgent transport for blood bags, hemocomponets, medical goods and other indispensable health needs are required all over the world. Current emergency transportation for medical needs, a market that will reach $93,2 Billion in 2021 needs a technological upgrade. The actual delivery process involves long waiting time, depends on a specialized driver and has to be delivered by road, or, when extremely necessary, by helicopter, both alternatives represent high direct and indirect costs (up to 2000€) that have to be faced by the medical facilities, the government and the citizens, while every minute lost could potentially endanger patient’s life.ABzero is a start-up that operates in the field of design and production of technological tools, specially focus in the healthcare sector. Created in 2017 in order to face current deficiencies in the healthcare system by giving the community an innovative solution adapted to the latest technologies. As a spin-off of Scuola Superiore Sant´Anna, ABzero have access to their state of the art BioRobotic laboratory and the latest research studies in both, the technological and medical field. ADrone4Life is capable of facing current high cost, long delivery time and deficiencies in the emergency transport for medical needs. This smart case is flexible and modular, able to adapt, guarantee and monitor its cargo conditions, such as blood bags and samples, organs or any other health need at any time while automatically control whichever latest technology drone it is attached to, in order to swiftly reach its required destination overcoming any weather condition. This innovation will offer a 80% time reduction compared current delivery time and 99% cost reduction translated into more than 2000€ savings for each delivery with n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced Butanol and Hexanol Production from CO2: Integrating Genetically Modified Clostridium strains in Bioelectrochemical Systems', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The production of butanol and hexanol from syngas (CO and CO2) fermentation represents a significant advancement in sustainable chemical manufacturing. This project aims to enhance the efficiency of this process by leveraging the capabilities of Clostridium ljungdahlii, a bacterium known for its robust syngas fermentation capabilities. C. ljungdahlii can convert CO2 into valuable products like butanol and hexanol, but current production levels are limited. Existing research shows that engineered strains of Clostridium can produce butanol at levels of 6–8 g/L from syngas. With ongoing advancements in genetic engineering, these yields are expected to rise to 10 g/L, and potentially up to 20 g/L with further metabolic engineering and optimized fermentation conditions. Similarly, while current hexanol production stands at 1–2 g/L, genetic engineering holds the potential to increase this to 2–3 g/L by enhancing chain elongation and managing acetate accumulation.The project here focuses on two main objectives: a) optimizing genetic modifications in Clostridium strains and integrating bioelectrochemical systems (BES) to address the current limitations. Genetic engineering efforts will target the Wood-Ljungdahl pathway (WLP), a crucial metabolic route for converting CO2 and CO into acetate. By knocking out the acoA gene (acetyl-CoA synthetase) and upregulating adhE (alcohol dehydrogenase), we aim to redirect carbon flux from acetate production to alcohol synthesis. Additionally, utilizing BES will help mitigate acetate toxicity and enhance product yields through electrochemical stimulation, which improves cellular redox metabolism and supports the conversion of excess acetate into butanol (C4) and hexanol (C6). In effect, this combined approach will increase the production of m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Exploring the expanding universe of RNA-binding proteins in bacteria'.

assistant: **Innovation**

All organisms use diverse modes of cellular control as they cope with changing environments. Central to these processes are RNA-binding proteins (RBPs) that impact the stability, translation, or localization of bound RNAs. While RBPs typically have distinct RNA-binding domains, a growing number of proteins that lack these domains are found to interact with RNA as well. In prokaryotes, such unconventional RBPs remain largely unexplored, in part because methods for global RNA interactome capture (RIC) in bacteria are missing. My group recently made a breakthrough in developing a novel RIC approach for bacteria that relies on primary transcript capture (CoCAP). Our pilot study successfully captured known RBPs but also uncovered numerous new RBP candidates, including metabolic or cell division proteins. We also identified a pair of widespread KH-domain proteins (KhpA/B) with links to the RNA degradosome and cell division. This points towards a wealth of unexplored RBPs involved in cellular control in bacteria. My ERC CoG proposal aims to explore the identity and functional diversity of novel RBPs in bacteria. My overarching hypothesis is that a vast, unexplored universe of unconventional RBPs exists in bacteria that play crucial roles in cellular physiology. I will tackle this through three objectives leveraging two model bacteria (Salmonella and Campylobacter) with different sets of canonical RBPs. I propose to:1) Elucidate bacterial primary RBPomes during stress- and infection-relevant conditions.2) Identify mechanisms and cellular functions of two widely conserved KH-domain RBPs.3) Determine how cell division RBPs influence and are influenced by bound RNAs.Our proposed work will provide a broadly applicable method for primary RBPome capture and vastly expand the set of b