RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Enhance process modelling system for lean operations management' (EPSYLON).

assistant: **Innovation**

The objective of EPSYLON is to define, implement and validate a new software for managing process information, allowing manufacturing firms to achieve, - Improved management of process data - the system will allow enterprises to capture, understand and formalise knowledge of their shop-floor processes; - Control over complementary operations - the system will support documentation, planning and monitoring of non-manufacturing operations such as recycling and maintenance; - Improved planning and decision-making functions - the common process representation will provide a unified, detailed and updated reference for both operative and strategic decision-making.The project is inspired by two main considerations, (i) Shop-floor processes are growing ever more complex, under the impact of factors such as, increased relevance of complementary tasks, running in parallel with the main production flow (eg prototyping, tooling, maintenance and quality control), higher flexibility required in shop-floor operation in terms of frequent re-configurations, number of parallel tasks, and shared personnel, and, arising 'green' manufacturing concepts, ranging from disassembly and disposal of take-back productions, to 'on-line' recycling of wastes and defective pieces; and (ii) current process models fail to capture and integrate all the knowledge elements necessary to describe this complex scenario, taking into consideration only the main production flow and do not adequately representing activities that run in parallel with normal production. In response, EPSYLON aims to produce, - A process modelling software with advanced primitives (e.g. generalised resources and operations, cyclical and alternative process paths, parameter based process configuration); - A short-term planning and cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrated analyses of aquaporin structure and function' (GLYCERO) targeting Sixth Framework.

assistant: **Abstract**

Aqua (glycero) porins (AQP) are represented in all classes of organisms, suggesting universal importance. Aquaporins transport water and AQP transport glycerol and other small- uncharged solutes. Aquaporins play important rules in human health. For instance, defects in AQP1 or 2 are known to cause diminished urine concentration ability and AQP4 of the brain-blood barrier is involved in brain swelling. This project aims at breakthroughs in our integrative understanding of the precise physiological roles of AQP. Work will also include studies on model organisms and mathematical modelling.The 3D structure of certain aquaporins has been resolved, providing a blueprint for understanding of the transport mechanism. Work in this project will target the structure of additional important aquaprorins with a view to understand transport of unusual substrates, mechanisms of regulation and inhibition of blockers. Since AQP plays crucial roles in physiology they are target for drugs. Built on existing lead compounds, such blockers will be further developed and their precise mode of action to be elucidated. Additional biotechnological applications for aquaporins are also subject of this network.AQP" is an interdisicplinary endeavour involving molecular cell biology, physiology of cell, tissue and animal models, clinical samples, yeast and fish genetics, protein production, purification and crystallisation, atomic force microscopy, electron crystallography, x-ray crystallography, molecular dynamics simulation, mathematical modelling as well as rational molecular design, organic chemistry and combinatorial chemistry. Hence, the project offers an interdisciplinary, international research and training environment of high excellence that is used for advanced training of early stage and exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Functional Low-Intensity Light Upconverting Inks for Everyday Applications' under Horizon 2020.

assistant: **Concept**

Spectral downconversion of visible or UV-light, that is the transformation of high-energy light into lower energy radiation, is used for a broad range of commercial products or applications and is therefore part of everyday life of most people. For example, highlighter pen inks contain organic dyes able to transform ambient UV-light into visible radiation making surfaces such as paper or fabric look bright. In contrast, optical effects based on light upconversion, that is the transformation of low-energy light into higher energy radiation, have barely been investigated since solid-state materials efficiently upconverting light at low intensities (< 100mW·cm-2) are only slowly emerging.The aim of this project is to conceive and prepare functional ink formulations capable of upconverting light by triplet-triplet annihilation (TTA-UC) therefore enabling unique new optical effects such as fluorescent patterns under near-infrared irradiation and a better applicability of upconverting solid-state materials. At the same time, the aim is to learn more about the intriguing phenomenon of triplet-triplet annihilation upconversion, which, as highlighter pen inks, is based on organic dyes.In order to obtain multicolour, designable and high throughput upconverting functional inks, the goals of this action include finding a suitable printing technique and substrates, such as inkjet printing on paper, developing coatable, printable and patternable solid-state light upconverting materials for ink formulations, such as modified rubbers or molecular glasses, analysing the morphology as well as the optical properties from the resulting prints and develop new custom-made solid-state upconverter concepts for printing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Taming non convexity?' (TAMING).

assistant: **Concept**

In many important areas and applications of science one has to solve non convex optimization problems and  ideally and ultimately one would like to find the global optimum. However in most cases one is faced with NP-hard problems and therefore in practice one has been often satisfied with only a local optimum obtained  with some ad-hoc (local) optimization algorithm. TAMING intends to provide a systematic methodology for solving hard non convex polynomial optimization problems in all areas of science. Indeed the last decade has witnessed the emergence of Polynomial Optimization as a new field in which powerful positivity certificates from real algebraic geometry have permitted to develop an original and systematic approach to solve (at global optimality) optimization problems with polynomial (and even semi-algebraic) data.  The backbone of this powerful methodology is the « moment-SOS » approach also known as « Lasserre hierarchy » which has attracted a lot of attention in many areas (e.g., optimization, applied mathematics, quantum computing, engineering, theoretical computer science) with important potential applications. It is now a basic tool for analyzing hardness of approximation in combinatorial optimization and the best candidate algorithm to prove/disprove the famous Unique Games Conjecture. Recently it has also become a promising new method for solving the important Optimal Power Flow Problem in the strategic domain of Energy Networks (as the only method that could solve to optimality certain types of such problems). However in its present form this promising methodology inherits a high computational cost and a (too) severe problem size limitation which precludes from its application many important real life problems of significant size. Proving that indeed th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Affordable frozen embryos of known sex for commercial cattle breeders', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The high cost associated with conventional methods for producing and freezing bovine embryos restricts the use of the technology to the high value pedigree sector of the cattle breeding industry. Frozen embryos are an extremely cost effective and bio secures method for dissemination of bovine genetics. In order to promote the use of this valuable technology in the much larger commercial sector, this project seeks to significantly reduce frozen embryo production costs. In-vitro maturation, fertilisation and culture (IVP) of embryos provides the best opportunity for reducing the cost of production per se, but IVP embryos do not tolerate the freezing process well and calving rates after embryo transfer into recipients are not commercially acceptable. The purpose of the research is to develop an effective method for freezing IVP embryos by defining the culture and freezing media constituents, which are necessary to produce an embryo with good post-thaw viability. It will also be necessary to develop a method for packaging embryos for freezing, which complies with animal health regulations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'OsteoCalcin Autophagy to reJuvenate motoneuronAL function' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Brain aging is characterized by a progressive decline of our nervous system functions. Elucidating the underlying mechanisms is of vital importance and represents an unmet medical need. Recent studies have highlighted the molecular contribution of several organs in brain aging, and emphasize the importance of systemic milieu in the control of cognitive fitness. Host has identified Osteocalcin (Ocn), a bone-derived hormone, as a rejuvenating systemic factor that improves memory in aged-mice. However, the impact of systemic factors in our locomotor functions and their therapeutic potential remain unexplored.CAJAL aims to elucidate the role of the pro-rejuvenating hormone Ocn in the age-related motoneuron (MN) and locomotor dysfunctions. Our preliminary data show that Ocn receptor is highly expressed in spinal MNs and that Ocn influences MN autophagy, an essential endogenous mechanism for locomotor performance. We propose to analyse the potential protective role of Ocn-autophagy in MNs to maintain locomotor activity. By shedding light on key molecular mechanisms fostering MN homeostasis, CAJAL could lead to new therapeutic strategies to treat/prevent age-related decline of locomotor system.The specific objectives are:1) Characterize the impact of systemic milieu/Ocn in regulating autophagy in spinal MNs2) Analyze the therapeutic potential of Ocn in age-related locomotor decline3) Decipher the role of Ocn-dependent autophagy in locomotor function and its signalling pathwayThe project is designed to extend my scientific expertise and transfer my knowledge in autophagy and MN homeostasis to Host. Project and risk management, intellectual property rights, and communication activities are meticulously planned. We have generated the required molecular tools and mouse models, as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'STRUCTURAL BASIS OF SRNA-MEDIATED TRANSPOSITION REGULATION IN BACTERIA' in the context of a Seventh Framework call.

assistant: **Objectives**

In bacteria, DNA transposons play a key role in transferring antibiotic resistance, which poses a major threat to human health. I want to understand how this transfer can be controlled. One of the regulatory pathways applied in vivo uses specific small RNAs (sRNAs) controlling translation of the transposase mRNA. This is achieved using the general bacterial RNA regulatory machinery, and is mediated by the small RNA chaperone, HFQ. HFQ is a highly conserved, SM-like protein that modifies the secondary and tertiary structure of sRNAs and mRNAs, supports RNA unfolding and annealing and thereby regulates mRNA translation. In addition, HFQ also recruits the RNA degradation machinery through interaction with the endonuclease RNaseE and the poly(A)-polymerase PAP-I. Now I aim to understand the mechanism of sRNA-mediated regulation of transposition and the general gene silencing process in bacteria, applying an integrated structural biology approach. Using fluorescence anisotropy, SPR, FRET, NMR spectroscopy and X-ray crystallography, I will study the structural changes of Tn10 derived RNAs upon binding to HFQ, the structure of the ribonucleoprotein complexes involved and the dynamics of RNA-folding and annealing. Furthermore, to investigate the intimate link between sRNA based translation regulation and RNA degradation, I will also analyze how HFQ interacts with RNaseE and PAP-I, and how these interactions affect the function of these RNA processing factors.My study will not only reveal the mechanism of sRNA based regulation of transposition, but also provide insights into the general RNA chaperoning functions of HFQ and a comprehensive picture about the macromolecular complexes and dynamic events involved in sRNA mediated gene regulation. On the long term, I envision that dow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Robust affinity materials for applications in proteomics and diagnostics' (PEPMIP) targeting Seventh Framework.

assistant: **Abstract**

PEPMIP represents a joint European effort involving eleven partners aimed at the development of the next generation of dedicated separation materials, designed to recognize peptides and proteins, and the implementation of these materials in new high performance methods for peptide and protein analysis. Artificial receptors will be developed by various Molecular Imprinting techniques. This will be supplemented by a new class of generic peptide and protein fractionation tools that will be integrated in new formats to produce new protein/peptide separation and detection solutions. The research results will lead to technological advances having a major impact on 1) health care since it will profit from methods involving PEPMIPs for earlier, more reliable diagnosis of diseases, 2) drug discovery allowing a faster target or biomarker identification; and 3) biochemistry research laboratories in resulting in improved protein fractionation tools for revealing low abundant post translational modifications. The training will focus on 10 early stage researchers (ESRs) who, within four work packages, will develop a well-balanced spectrum of scientific, business and entrepreneurial skills that will be particularly attractive to European industry when the ESRs eventually leave PEPMIP.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'MEM’S: My Easy Moving System' (MEMS).

assistant: **Concept**

In Europe more than 600,000 people are disabled in their natural mobility but are able and need to drive since they are of employment age: we want to bring to them an innovative independent mobility solution that overcomes the limitations of the devices currently available. By using robotics-based technology, our solution will allow the disabled person to use his electric wheelchair as a driver's seat in his car, without any intervention or assistance required of third parties while getting into and out of the car, in this way fully achieving his freedom of movement. Our innovation provides the disabled with total independence, greater comfort and saving two-thirds of the equivalent average expenditure incurred today. Our solution has been designed as original equipment to be installed by carmakers, just as it can be installed in a car one already owns: it is the first sustainable standardisation solution for disabled people in the automotive sector.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Aerial Transport for Remote Areas' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Shipping to and from remote locations is costly and challenging. In the Alps (Europe) there are plenty of mountain shelters that cannot be accessed with vehicles. Those mountain shelters depend on the expensive and inefficient transport service of helicopter companies.FlyingBasket offers aerial transport services for medium payloads of up to 100 kg. This service will be offered in combination with our innovative multicopter (UAV), called FB3 capable of lifting payloads of up to 100kg. Our multicopter will use a pure electric propulsion system and batteries for energy storage. An aircraft like this is a compelling goal due to low noise, no exhaust gases, and battery energy transformed to motive power exceeding 80% efficiency.Founded by Moritz and Matthias Moroder in 2015, FlyingBasket has the necessary expertise to carry out the Phase 1 Feasibility Study. Our young team holds complementary competences in the technical field and in project management. We plan on hiring additional skills for production, development and marketing activities, growing to 95 employees by 2025.  The Feasibility Study will be used to acquire a deep understanding of the market, competitors, customer segments, end-users and stakeholders, the company plans to reach TRL9 through the SMEI-2 by 2021.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'High performance functional bio-based polymers for skin-contact products in biomedical, cosmetic and sanitary industry' under Horizon 2020.

assistant: **Concept**

Personal care, Cosmetic and biomedical industries deal with high-value and/or large volume consumption of polymer-based products which are often derived from fossil sources. Although a number of alternative bio-based polymers is the subject of recent research, more effort is still needed to increase their specific functionalities and performances in order to proceed with their true translation into market. PolyBioSkin aims at developing skin-contact biopolymer-based product parts with increased performance and functionality, such as parts of diapers, cosmetic pads and wound dressings. Indeed, PolyBioSkin will focus on two main classes of bio-based polymers relevant for next generation bio-based industry: biopolyesters (polylactic acid and polyhydroxyalkanoates) because fully renewable, biocompatible and biodegradable and available at an industrial scale, and natural polysaccharides (cellulose/starch and chitin/chitosan), derived from biomass and food waste, for their peculiar properties, such as absorbency and anti-infectivity. Films and textiles will be produced starting from these polymers and their combinations to prove that key products and/or product parts in sanitary, cosmetic and biomedical industry can be effectively translated from a fossil-derived to bio-based polymer production. PolyBioSkin will provide to skin-contact products a much more environmentally friendly end of life than the current accumulation in landfills or incineration, thanks to their biodegradability allowing the organic recycling.


**Keywords:** biopolymers, biopolyesters, biopolysaccharides, bio-based, skin, diapers, wound dressing, anti-microbial, functionalities, anti-oxidant, personal care, sanitary, cosmetics, biomedical