RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Genetic and Chemical Selection of New Molecules which Interfere with Cell Adhesion and Signal Transduction' (1994-1998).

assistant: **Innovation**

- To screen peptide libraries and low molecular weight compounds which interfere with cell adhesion and tyrosine kinase receptors.- To use DNA delivery systems for inhibition of factors responsible for signalling and restoration cell adhesion. - To construct mouse lines which will act as drug tester systems.Cell adhesion is essential for tissue development and organization, and abnormal adhesion plays a key role in a variety of diseases, notably in inflammation, certain diseases of the skin and metastasic cancer. The research is directed toward the discovery of new molecules that interfere with regulation of adhesion and may be used in therapy. It builds on two important development: (i) recent knowledge of the sequences, structures and functional regulation of adhesion molecules and (ii) the discovery that growth factor-induced cell signalling plays a key role in the regulation of adhesion. We will use three complementary approaches in order to develop cell adhesion therapy. The first will include the screening of (i) peptide libraries for sequences that abolish ligand-receptor binding related to cell adhesion, (ii) phosphopeptide libraries for selection of sequences interfering with receptor-substrate interactions, and (iii) low molecular weight lead compounds for transcriptional activation of the genes for cell adhesion molecules. The second approach will employ DNA delivery systems for inhibition of factors responsible for cell signalling and for restoration of cell adhesion. This will entail the development of DNA delivery vectors with improved cell selectivity and the expression of gene fragments interfering with signalling in a dominant-negative fashion. The third critical approach will involve the construction of mouse lines carrying transgenes for signalling or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Combining Shape-change and Biofeedback to Improve Mental Health Delivery'.

assistant: **Concept**

Mental health conditions are set to become the leading cause of mortality and morbidity worldwide by 2030 (at a projected cost of €14.8 trillion), surpassing other major health concerns. The most effective path to lasting recovery involves Mental Health Professionals (MHPs), but despite significant efforts, they currently can only help around one in three patients recover during treatment. MHPs lack adequate tools and remain ill-equipped to support the 970 million people in need of mental health care. Typical treatment cycles involve only one hour per week to rewire maladaptive responses, while digital alternatives suffer from a low two-week retention rate of 3.9%.Ankor is a unique and scalable solution designed to help MHPs deliver faster, more effective treatments, aiming to double recovery rates and extend support to over 100 million additional patients; for whom existing solutions have failed. By integrating biosensing, AI, and real-time shape-changing mechanisms, Ankor enables both patients and MHPs to interact with and modify physiological and psychological responses, making mental health care more tangible, accessible, and easy.The primary objective of this project is to explore and validate the innovation potential of our technology, with a focus on building customer traction and identifying viable market pathways. Specifically, we aim to: (1) construct functional demonstrators to advance the capabilities and reach of our technology; (2) engage with potential customers and establish relationships with key stakeholders, gain insights into market needs, and assess the commercial viability of Ankor; (3) create a market validation report that quantifies the demand for our technology and outlines a market entry strategy with measurable milestones.Through this project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Development of composite Metamaterials having Negative stiffness inclusions and exceptional Damping properties'.

assistant: **Innovation**

The EU is a world leader in the development and manufacturing of structural products for the transport industry, with theaeronautical sector alone providing more than 500,000 jobs, generating a turnover of close to €140 billion in 2013 . Noise isa serious form of environmental pollution affecting the lives of hundreds of millions of citizens worldwide and having multiplesocio-economic consequences. Moreover, intense vibration can endanger the structural integrity and performance ofequipment and hardware. Modern industrial structures are made of composite materials due to their well-known benefits.Despite their superior structural characteristics, composite structures exhibit poor dynamic and acoustic isolation levelscompared to conventional metallic ones. In order to keep noise and vibration levels at acceptable limits, structuralmanufacturers are nowadays obliged to extensively employ constrained-layer damping treatments that are expensive interms of additional mass and space usage.DiaMoND will bring together an ER being expert in ‘wave propagation and acoustics of mematerials’ and ahost institution carrying leading academic know-how in ‘design, optimization and manufacturing of multifunctionalcomposites’. The Fellowship aims at developing novel structures having exceptional damping properties combined with theoutstanding structural performance of a layered composite at minimum extra mass, volume and cost. This will be attainedthrough the inclusion of internal purely mechanical Negative Stiffness elements in the core of the structure. Accordingto conservative preliminary simulations, a successful completion of DiaMoND will deliver structures that have a dampingratio at least 300% superior (for the same stiffness/mass fraction) to that of the structures currently employ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'The universe at high redshift and the physics of active galaxies from multi-wave length studies of compact radio sources - consortium for European research on extragalactic surveys'.

assistant: **Objectives**

CERES tackles the most intellectually stimulating problems of our age and investigators are a unique resource for the study of the distant Universe. the young scientists will work near current limits of technology, thus providing an ideal environment to learn the necessary skills of advanced We propose a coordinated European programme to: research. The partners organize many seminars and lectures for the 1. determine the Hubble constant Ho from gravitational-lens time-delays education and training of their staff. Each post-doc will be assigned an 2. constrain the cosmological density parameter Omega zero, the cosmological constant Lambda zero, and galaxy mass distributions, from lens statistics experienced adviser. Exchange visits and workshops will be organized. 3. make VLBI measurements of quasars to constrain the deceleration parameter qO 4. find the most distant quasars 5.identify damped Ly-alpha systems & to map the neutral hydrogen absorption in these probable spiral-galaxy precursors in the 21cm line 6. quantify how much our view of the Universe is censored by dust obscuration 7. study the physics of quasars The priority activity during the first 2 years will be the compilation of optical identifications and redshifts. The radio work and that on the tasks above will proceed in parallel.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ecology of Wild-life, Livestock, huMan and Infectious Diseases in changing environments' (WiLiMan-ID).

assistant: **Innovation**

WiLiMan-ID addresses the complexity and the dynamics of the host-pathogen interactions for five animal infectious diseases (IDs) that are ranked as high priority by the EU (Avian influenza, African swine fever, West Nile fever, African horse sickness, and Chronic wasting disease). These IDs circulate in livestock and wildlife and, at the human-animal interfaces: two are causing severe economic losses to farming systems and three represent a threat to human health. The main objective of WiLiMan-ID is to identify key factors driving their emergence and dissemination in ever-changing environments by integrating data at different scales (pathogens>host>community of hosts>territory) and, to provide farmers, health services and policy makers with innovative strategies and methods for prevention, surveillance and control for the IDs considered in WiLiMan-ID and beyond.To meet this objective, WiLiMan-ID will in particular:- Improve methods for sensitive and accurate detection and identification of pathogens and their variants in complex environments.- Identify drivers promoting the increase in pathogen virulence, transmissibility and/or host-shift.- Assess the impact of host factors as a key parameter of pathogen evolution and dynamics, such as vaccination or pre-existing immunity to viral infection.- Identify transmission routes, the role of vectors, the impact of the environment (pathogen reservoirs in wildlife, global change impact on migration routes) and of the management practices (farming, trade, transport) on pathogen dissemination and transmission.- Develop next-generation analytical approaches for optimized surveillance and management strategies of IDs, within a context of global changes.- Disseminate and communicate the results to stakeholders and engage in further c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for '3D GaN for High Efficiency Solid State Lighting' under Seventh Framework.

assistant: **Concept**

Solid State Lighting sources, presently being completely based on the semiconductor material Gallium Nitride, will replace inefficient and environmentally harmful conventional light sources, and therefore contribute significantly to a sustainable energy saving and carbon footprint reduction. In order to further support this transition, white LEDs with higher efficiencies and lower cost per lumen have to be developed. The main strategy of GECCO is based on exploiting the vertical sidewalls of 3-dimensional GaN structures with high aspect ratios, where the p-n-junction region is fabricated along the vertical sidewalls of the 3D structure so that this large area can be used as an active area for light emission. Whereas conventional approaches for light emitting material are planar, our GECCO approach exploits the third dimension and is expected to overcome potentially all of the limitations of present GaN material technology, making substantial progress towards the long term goals mentioned in this call (2020): enhanced overall efficacy of white light emission. We will investigate material related aspects of 3-dimensional (3D) GaN in order to get a good handle on the interesting properties of this new class of material, so that it can be used for highly efficient and cost effective whitelight emission. The overall GECCO project objectives are:1.)achieving full control on the growth of high quality 3D GaN material.2.)achieving full control on doping and growth of ternary compounds (InGaN and AlGaN) on the non-polar sidewalls of 3D GaN structures.3.)extending the 3D approach from GaN cores to InGaN cores, with the goal to bridge the green gap (low efficiency for green quantum wells).4.)implementing novel phosphor materials and concepts for a more efficient, 3-dimensional way
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'In vivo dynamics and plasticity of networks within CA3 of the hippocampus: effects of optogenetic stimulation and natural learning.' (CA3RECURRENTPLASTIC).

assistant: **Innovation**

The CA3 subregion of the hippocampus is crucial for the formation of episodic memories on a short timescale, possibly due to synaptic plasticity in the recurrent connections between pyramidal cells. Previously, in vivo observations of these changes due to a learning event were elusive; however, in the current proposal we will use new methods to allow us to observe and manipulate the changes that occur in cells and synapses correlated with memory formation. To achieve this, we will combine optogenetic stimulation techniques with both intra- and extracellular in vivo electrophysiology to measure cellular properties, network dynamics, and both artificially- and naturally-induced synaptic plasticity. Additionally, we will restrict optogenetic expression to only those cells involved in the memory, allowing us to selectively identify and manipulate these cells. Stimulation of a subset of CA3 pyramidal cells while recording the intracellular trace from an individual CA3 pyramidal cell will provide the first insights into the nature of the recurrent network in vivo; incorporating stimulation protocols designed to induce synaptic plasticity will allow us to characterize different forms of plasticity in vivo. Adding stimulation of DG inputs to this protocol will allow us to measure the modulation of both activity and synaptic plasticity. Finally, we will test the effect of natural learning on the CA3 network, by recording extracellular activity in vivo, and taking measurements of cellular properties and synapse strength ex vivo. This project will allow us, for the first time, to link the single-synapse changes hypothesized to be crucial for memory with whole-animal learning.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Quantifying landslide activity and contribution to sediment fluxes with cosmogenic radionuclides and grain-size distributions' (LandFlux) targeting Horizon 2020.

assistant: **Abstract**

Landslides are a primary erosion process in steep landscapes and are among our most deadly and damaging geohazards. However, it is extremely difficult to constrain long-term or past rates of landslide activity, which prevents accurate predictions of their activity in the face of climate change. This project aims to develop and apply a new methodology to quantify long-term landslide activity and contribution to sediment fluxes. To achieve this goal, I will integrate two growing research lines that have identified signatures of landslide activity: grain-size distributions and cosmogenic radionuclide (CRN) concentrations, which I will integrate in a numerical model. We will exploit, for the first time to our knowledge, the differences in depth production profiles between CRNs (14C and 10Be), using the 14C/10Be ratio to infer erosional depth-provenance and track erosional processes. We will sample grain-size distributions, and 14C and 10Be concentrations across different grain sizes, in landslide deposits and river sediments within catchments with excellent published constraints on landslide activity in Italy and New Zealand. We will develop a new Matlab numerical model, which will be calibrated using our new data, to determine landslide rates and fluxes using CRN and grain-size data, hence creating a tool that can be used to predict long-term or past landslide activity in other areas where good constraints are not available. This project has the potential to expand the uses of CRNs to include erosional depth-provenance. Furthermore, being able to infer long-term and past landslide rates would be a major step forward in how we tackle landscape evolution and landslide hazards. This project will be developed at the GFZ Potsdam (host) and ETH Zurich (secondment), bringing toge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Endoplasmic Reticulum-Mitochondria contact sites structural and functional adaptation during Insulin Resistance' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The high calory intake and the sedentary behaviours represent one of the most common stress to which humanity is subjected. This is leading to an increased incidence of obesity that can be aggravated by dysfunctional metabolism, among which insulin resistance (IR) is the most common scenario. Two crucial processes know to lead to IR are Endoplasmic Reticulum (ER) stress and mitochondrial dysfunction. Mitochondria and ER are in tight physical contact through the mitochondria-associated ER membranes (MAMs), which are emerging as an important hub for glucose homeostasis. MAMs are involved in a plethora of cell functions, such as lipid synthesis, ROS and Ca2+ signalling, autophagy and inflammation, all processes tightly linked with cellular insulin sensitivity. In support to this notion, MAMs miscommunication was shown to occur in the presence of IR. Nevertheless, no conclusive molecular mechanisms can explain MAMs adaptation during IR. Furthermore, how MAMs remodelling affects the signalling between ER and mitochondria (Ca2+, ROS, lipid exchange) during IR progression and how this affects ER and mitochondria functions are still open questions. The overarching aim of this proposal is to characterize the alterations of intracellular signalling in mouse models of hepatic IR at the level of MAMs and to develop a standardized methodological approach to assess inter-organelles signalling changes during pathophysiological cues. To this goal, I will implement innovative approaches in vivo to quantify these contacts and to identify the MAMs molecular composition during IR. Furthermore, I will characterize the consequence of IR on MAMs signalling pathways by combining ‘omics approaches and imaging technics, to identify the molecular and functional signature of the MAMs during the IR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Quantum Theory and Statistics' (QUANTSTAT) targeting Seventh Framework.

assistant: **Abstract**

The proposed project addresses fundamental problems at the mathematical/statistical foundations of quantum information theory, with a special focus on the problem of discriminating quantum states. The main goals are to study asymptotic state discrimination under locality constrained measurements, to explore how criticality of the systems influences the validity of asymptotic state discrimination results, to extend existing binary results to multiple hypotheses,  to determine the strong converse exponents for binary state discrimination and classical information transmission through quantum channels, and to investigate the approximate correctability of quantum noise that does not change the distinguishability of states too much. These will be addressed through a systematic study of operator distinguishability measures and their behaviour in the given specific problems.The results of the project are expected to shed light on the role of quantum correlations in state discrimination andthe classical information transmission capacity of quantum channels, and yield a better understanding of the asymptotic behaviour of information quantities in critical quantum systems. These questions are at the forefront of current research in quantum information theory and the results of the project are expected to have a great impact on the field.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Immigrants and ethnic minorities in european cities : life-courses and quality of life in a world of limitations' (LIMITS) under Fifth Framework.

assistant: **Objectives**

This project explores the impact of the socio-economic and legal contexts on the life Courses of immigrants and ethnic minorities in the post-migration-phase. Starting from the often stated limited upward mobility of immigrants, the integration of different decision models will allow for an improved understanding of their coping strategies. Supported by event history analysis and optimal matching as a tool for sequence analysis, 3.900 individual life trajectories of immigrants in seven European countries will be analyzed in the temporal context of the respective community histories and macro economic indicators such as labor market data and legal frameworks in the selected cities and countries. The projected results will be an extensive database with conclusions for future policy development in relation to immigrants.