RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Improvement of SQGs through the incorporation of chronic exposure-effect model' (CHEEM).

assistant: **Concept**

Sediments are extremely important to the food web and serve as the ultimate repository and source of most of the contaminants, including metals. For this reason, it is appropriate that regulatory attention addresses the ecological risks that these sediment contaminants might pose. So much so that, the need to understand the impacts of contaminated sediments on aquatic environmental quality is implicit in the text of the Water Framework Directive (2000/60/EC), and in the Directive on Environmental Quality Standards in the field of water policy, different metals have been included in the group of substance identified as priority on account of the substantial risk they pose to or via the aquatic environment. Currently, the first tool to assess metal sediment quality is the use of Sediment Quality Guidelines (SQGs). The SQGs represent an important tool for flagging potentially toxic metal levels in sediments, indicating which sediments may be or no concern and those which merit a closer-look. However, the level of protection offered by current SQGs is far to be totally efficacy. Significantly more research is required into the chronic and sub-lethal effects of dissolved metals and the metal exposures from dietary sources (e.g. food and sediment ingestion). The purpose of this project is to develop an environmental exposure-effect model to predict copper chronic effects in order to improve the effectiveness of the SQGs. This project addresses directly the Community policy established by Water Framework Directive 2000/60/ec and enhances furthermore the development of ecotoxicological tools to prevent the pollution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Quantum Dynamics of Strongly Correlated Systems and Ultra-Cold Atomic Gases', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The realization of strongly correlated quantum systems by means of ultra-cold atoms is now an achieved reality.Beyond the early studies of thermodynamic equilibrium properties, these systems offer unprecedented possibilities to study their dynamics. Crucial theoretical challenges therefore concern modeling and understanding quantum dynamics in the presence of strong correlations.Our main goal is to develop new numerical approaches to tackle questions currently intractable by state-of-the-art techniques. We will use and suitably extend the “Time-dependent Variational Monte Carlo” method, to whose early development the Fellow (Dr Giuseppe Carleo) has tightly contributed and whose accuracy has been already demonstrated.In the first phase of the Project we will concentrate on lattice bosons. We will investigate the role of the dimensionality and of long-range, dipolar interactions in the time-propagation of quantum correlations. We will moreover study the interplay of disorder and interactions, focusing on dynamical signatures of the many-body localization phenomenon. In the second phase, we will extend our numerical technique to correlated gases in continuous space, studying how the ergodic hypothesis in their approach to equilibrium can be violated. All of the mentioned dynamical regimes have been, since now, fundamentally inaccessible to accurate numerical methods.The Host Institution is the Laboratoire Charles Fabry (LCF) at Institut d'Optique and CNRS. LCF has consolidate experience in ultracold atoms with world-leading experiments and theory. The Applicant will join the theory group led by Dr Laurent Sanchez-Palencia and will develop direct collaborations with the lively experimental activity at LCF. On one hand, the mobility will be beneficial for the Fellow to be tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'How viruses switch between glycan and protein receptors and what it means for past and future pandemics' (GLYCvsPROT) targeting Horizon Europe.

assistant: **Abstract**

To enter a host cell a virus needs to bind a receptor on the cell surface. Typically, viruses use specialised glycoproteins to bind to either glycans or proteins as receptors. The specificity and affinity of a virus glycoprotein for cellular receptors is a key determinant for which hosts a virus can infect. Certain enveloped viruses of high pandemic potential, such as influenza A and coronaviruses, have an ability to change their receptor specificity from a glycan to a protein receptor, and in some instances, even bind both with one glycoprotein. These receptor transitions might have contributed to emergence of pandemic viruses, such as SARS-CoV-2, and may underlie future pandemics.Studying the structure and evolution of viral glycoproteins and their receptor complexes can help to understand the mechanisms viruses use to cross the human species barrier. I will build on my recent studies and pilot data on the structure and evolution of viral glycoproteins, and employ the glycoproteins of influenza viruses and coronaviruses which can bind to either or both receptor types to show:- how different receptor types are recognised structurally by very similar viral glycoproteins- how receptor type affects interaction avidity and mechanisms of viral fusion- how receptor transitions may arise during viral evolution and influence its directionThis will be achieved by combining structural, biochemical, and biophysical approaches to reveal interactions between viral glycoproteins, influenza haemagglutinins and coronavirus spikes, with glycan and protein receptors. My studies will provide key new insights into the plasticity of viral glycoproteins and the evolutionary pathways associated with changes in receptor specificity, thus shedding light onto emergence of pandemic viruses such
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Towards the development of an effective enzyme replacement therapy for human alpha- mannosidosis' (HUE-MAN).

assistant: **Innovation**

Alpha-Mannosidosis is a rare inborn disorder caused by the lack of the lysosomal enzyme a-Mannosidase, resulting in mental retardation, skeletal changes, hearing loss and recurrent infections. The children are often born apparently normal, and their conditions worsen progressively, without any possibility to prevent this evolution. In the children that are born healthy, a therapy initiated at an early age could contribute to a normal development. Today, the most promising therapy for lysosomal storage disorders is enzyme replacement therapy (ERT); where the enzyme lacking in the patient is introduced into the blood stream, from where it is internalised by the cells and reaches the lysosomes, acting as the endogeneous enzyme. ERT products are on the market today for diseases such as Gaucher and Fabry and clinical trials are underway for a number of other diseases. Within the 5th EU framework the collaboration EURAMAN succesfully established an enzyme replacement therapy for a mouse model of Alpha-Mannosidosis. A correction of storage in many tissues including brain was found after administration of lysosomal acid a-Mannosidase (LAMAN) from bovine kidney, and human and mouse recombinant LAMAN. An application for the designation of human rhLAMAN as an Orphan Drug has been submitted.In the HUE-MAN proposal, the main objective is to transfer and expand the knowledge obtained from the EURAMAN project studies to investigate and establish clinical parameters in the mouse model and a natural history study of the human disease in order to define clinical endpoints for the future clinical trials in a-Mannosidosis.Furthermore, in parallel, HUE-MAN will upscale the production of rhLAMAN and perform the initial toxicology studies that can pave the way for a First Clinical Trial in Ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Macroeconomics of Managers' (MACROMGR).

assistant: **Concept**

There are enormous differences in productivity both across countries and across firms within the same country. Not only is the average firm less productive in poor countries, the allocation of resources across firms is also less efficient. Good management is understood as one of the key determinants of firm performance. Why don't management best practices spread from good firms to bad ones and from rich countries to poor ones? In order to explain management practices and productivity at the macroeconomic level, we need to understand where good managers come from and how they are allocated across firms. I  propose a new research agenda of the macroeconomics of managers. I will build three quantifiable theories to describe the market for manager skills and estimate them in new longitudinal data on the universe of firms and top managers in Germany (1991-2021) and Hungary (1980-2021). I will study the increased demand for manager skills after economic liberalization of the 1990s, the geographic and other frictions stopping managers from reaching their full potential at their ideal firm, and the spread of trading practices between firms as managers move. My research will show how the misallocation of manager skills across firms, space, and time can contribute to lower aggregate productivity.


**Keywords:** development accounting, management, assignment model, overlapping generations model, linked employer-employee data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Sustainable Urban Metabolism for Europe'.

assistant: **Concept**

Societies in their urban (and also non-urban) segments, are extracting materials and energy from their natural environment, processing these flows, eventually accumulating portions of them as stocks and, in the end, deleting them into the environment as wastes, emissions or deliberate discharges. Urban settlements – cities – are a specific type of stocks in the metabolism of societies, and the way these cities are being built and operated has a substantial influence on the quantities and qualities of material and energy flows needed to sustain their existence. In SUME, the urban metabolism shall be understood as a metaphor for our societies’ way of dealing with its natural environment. With global climate change, limited resources and sources of energy, the question of how a healthy level of metabolic exchange with the environment can be achieved is gaining a dramatic new actuality. It is the question of how existing urban areas shall be transformed and new cities or expansions should be planned – to be researched in SUME with a truly comprehensive approach. The concept of urban metabolism, as understood and applied in SUME, will be including all relevant flows (material, energy, waste etc.), and – as link to future planning – consider the influence of the various urban spatial forms and ways of urban restructuring on the levels and qualities of the flows. In order to search for a reduced extraction of resources and energies, new criteria for planning and governing of urban development will be needed. The urban metabolism approach will be tested as a guideline for such knowledge and methodological improvement. As a comprehensive approach, the concept of metabolism also is scrutinizing the effects of investment, asking if an intensified use of flows for the renewal of ur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Restoring Emotional Stability through Neurofeedback and AI for Transformative Empowerment'.

assistant: **Concept**

Emotion regulation (ER) is the key to mental well-being. Disruptions in the brain ER circuitry is a transdiagnostic mechanism underpinning a wide spectrum of affective disorders that contribute to the mental health economic burden of 600 billion euros annually in Europe. This project focuses on Major Depressive Disorder (MDD), predicted to become the leading cause of global disability by 2030. Conventional treatment is ineffective for approximately 40-60% of patients, underscoring the crucial need for innovative therapeutic approaches. In this context, neurofeedback (NF) on ER with functional magnetic resonance imaging has emerged as a promising tool for the treatment of MDD in research settings. NF is a training that enables people to regulate their brain activity by providing real-time feedback on specific brain patterns, in this case on brain areas involved in ER. To bridge the gap between clinical practice and academic research, RESoNATE will validate the clinical effectiveness of an electroencephalography (EEG) NF protocol targeting ER circuitry. Going beyond the current state of the art, we will conduct a placebo-controlled study involving 72 MDD patients, stratified into NF, sham-NF(placebo), and control groups. A collaboration with the National Kaohsiung Medical University (Taiwan) will add a second NF dataset of 60 subjects. The second goal entails advancing the validation of novel deep learning algorithms for EEG time-series data analysis and testing generalization to different cultural datasets, deploying them to predict the success of NF—a key challenge within the field. By incorporating a startup into the project, we will explore the industrial potential of this research. As such, through RESoNATE and its objectives psychiatrists, psychologists, AI experts,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Distributed internet content exchange with mpeg-7 and agent negotiations' (DICEMAN), addressing dissemination and exploitation.

assistant: **Impact**

Main ObjectiveDICEMAN intends to provide a solution to what is probably the single biggest problem facing the archive content industry and its consumers today. Content holders have vast quantities of material which they would like to sell. Content consumers have a growing need to access and purchase this content. However, today's business model is primarily based on paper, video tapes and CDs, and the postal system, making it slow, expensive and cumbersome. In this era of digital content and global digital networks, it is time a digital solution to this problem revolutionised the industry. DICEMAN aims to do this by:1.Opening up valuable databases of multimedia content by making them easier to search, using:  -advanced forms of descriptions and indexing  -advanced forms of user interfaces 2.Enabling the location of the best content for a given purpose, both locally and globally, over electronic networks, using agent-based assistants to users and provider.3.Enabling the exchange and trading of multimedia content over electronic networks using standardized interfaces to electronic databases. Technical ApproachDICEMAN is an end-to-end chain for the indexing, storage, search and trading of digital AV content. To this end, it aims to develop a technical reference model based, where possible, on existing and emerging standards. Technical work will focus on the elements of the DICEMAN system to produce a demonstrator that effectively shows the benefits of the DICEMAN approach in selected scenarios. In a few important ancillary areas, like electronic payment and rights management, the project will not actively develop technology, but will inform itself about technologies in these areas to ensure the DICEMAN system is sufficiently generic to accommodate them. It will also establ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Luminescent Nanocrystals in a Cage for Solar-to-Fuel Conversion'.

assistant: **Objectives**

Artificial photosynthesis, which can produce hydrogen and oxygen from solar irradiation, is one of the possible means to provide clean and renewable energy. Despite the recent progress, this emerging field is challenged by huge technical and scientific questions. In natural photosynthesis light absorption and catalysis occur in different sites of the leaf. In a simplified scenario, the energy harvested by the light absorbing pigments is funnelled towards the oxygen evolving complex. Here, we propose to realize the same biologically-inspired scheme using a novel hybrid system consisting of colloidal quantum dots embedded in a metal organic framework cage (CQD@MOF). In particular, a CQD Förster-transfer based light harvesting antenna will directionally transfer energy to a catalyst located in separate sites of the device. In addition to the rich basic science opportunities behind the introduction of this new concept in artificial photosynthesis, full-solar spectrum harvesting deriving from the characteristic size-dependent band gap tunability of CQDs, the potential for high voltages by combining CQDs of different size and composition, and the lack of contact between the light absorber and the electrolyte, intrinsic to the proposed device architectures, are all advantages that make this CQD@MOF hybrid Förster-based scheme highly appealing. One of the key component of the research will be to develop synthetic schemes to access these multifunctional systems with an unprecedented level of control through multiple length-scales. The experience and the skills gained by the applicant during her earlier carrier in the device fabrication together with the long-standing experience of the supervisor in this field will be extremely beneficial for a successful outcome of the proposal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Collection of Ancient Vergilian Exegesis: A Thousand Years of Scholarship on the Aeneid' in the context of a Horizon Europe call.

assistant: **Objectives**

The Aeneid, Vergil’s masterpiece, published in 17 BC, two years after the death of the author, is universally recognised as the most important Roman epic poem. Since the very beginning of its circulation, in the 1st c. AD, it has drawn the attention of philologists and has been included in the school teaching of Latin grammar and rhetoric; in the following centuries an increasing number of commentaries on the Aeneid has been produced, engaging generations of scholars up to modern times. Therefore Vergil’s poem has not only played a key role in the history of poetry in Western literature and, more generally, in the reception of classical civilisation, but also in the history of the linguistic, rhetorical, and literary education in Europe as well as in the development of scribal practices and philological methodologies across Antiquity and Middle Ages.From the first 1000 years of such exegetical effort, two complete commentaries, countless glosses, Greek translations, and grammar books have survived: their tradition, that counts approximately 160 witnesses and also includes papyri and late antique parchments, is closely intertwined. The rich variety of the ancient and early medieval scholarship on the Aeneid can now be systematically investigated and illustrated thanks to digital humanities. Focussing on the first millennium of the transmission of the poem, CAVE aims to collect and critically edit the ancient and medieval exegetical works on the Aeneid, and to reconstruct, in a broader perspective, the places, moments, cultural environments, teaching practices in which Vergil’s masterpiece was studied. CAVE addresses these challenges with a multidisciplinary approach, gathering experts in textual criticism, palaeography, digital humanities, history of scholarship, linguis