RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nanobodies to prevent hematopoietic stem cell bias and hyper-inflammation.' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

With a growing ageing population, there is an imminent demand to develop new therapeutic strategies to ameliorate disorders of the hematopoietic system. Our innate immune system can remember its previous encounters with inflammatory triggers. Epigenetic memories of previous inflammatory experiences throughout an individual's lifetime are imprinted in hematopoietic stem cells (HSCs), a small pool of bone marrow progenitors that give rise to all our blood cells. Inflammation harms HSCs causing their functional decline and premature ageing. It also causes long-term differentiation bias, and a heightened basal inflammatory status, known as “inlfammageing”. The most striking characteristic of aged HSCs is their increased expression of platelet and megakaryocyte markers and their commitment towards platelet biogenesis, referred to as “Platelet-bias."" Platelet bias has important consequences to human health. In our ERC starting grant project PLAT-IL-1 (714175), we discovered that platelets boost the inflammatory capacity of innate immune cells and are essential for the cytokine production of human monocytes. Our findings support that a dangerous combination of myeloid and platelet bias in inflammation-exposed HSCst results in a  heightened innate immune activation. The injuries to HSCs are persistent and continue even after the clearance of the inflammatory insult, indicating that remnants of inflammatory events accrue and prolong damage to HSCs. Hence, if we could “erase"" these harmful remnants, we could UNBIAS HSCs differentiation and prevent hyper-inflammation. In our ERC-funded project, we developed novel nanobodies that efficiently eliminate remnants of inflammation in vivo. In this PoC project, we will test the ability of nanobodies to erase memories from previous infl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Development of a new generation of anti-inflammatory steroids based on novel type of molecular crosstalk between the glucocorticoid receptor and NF-KAPPAB transcription factors'.

assistant: **Concept**

The recent discovery of molecular crosstalk between the glucocorticoid receptor and members of the Rel family of transcription factors provides a basis. - to obtain a better understanding of the anti-inflammatory and immuno-suppressive action of glucocorticoids. -to develop cellular test systems to determine efficiently the anti-inflammatory and immuno-suppresive action of existing steroids and other agents.- to provide a basis for the development of new steroids and other drugs in this area.Synthetic glucocorticoids are hormone analogs with strong anti-inflammatory and immuno-suppressive properties and are therefore widely used as drugs in asthma, rheumatoid arthritis, topic dermatitis, and after organ transplantation. Despite the fact that these substances closely resemble the normal hormone present in the body, side effects are very common and therefore can cause serious problems (e.g. osteoporosis in chronically treated patients). A second important problem preventing patients from receiving adequate treatment with glucocorticoids is pre-existing or developing resistance to steroid treatment. Like other steroids, glucocorticoids mediate their effects upon binding to high-affinity receptor proteins acting in the nucleus of the cell as ligand-activatable transcription factors switching on (or off) specific target genes. Steroids and their cognate receptors however are not the only type of signal molecules involved in expediating extracellular signals into the nucleus governing gene transcription; a (probably) limited number of other relatively well-known signalling pathways are present in a given cell, usually activated by factors of polypeptide nature (cytokines, peptide hormones and growth factors) as they bind to specific receptors in the plasma membrane.Signal tra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Hybrid Node Modes for Highly Efficient Light Concentrators' (HyMoCo) under Horizon 2020.

assistant: **Objectives**

The meaning of solar energy for future decentralized power supply will largely depend on both efficiency and cost of solar to electrical power conversion. All kinds of conversion strategies including photovoltaics, concentrated solar power, solar to fuel and others would benefit from efficiently collecting solar power on large areas. For this reason luminescent solar concentrators have been developed for over thirty years, but due to waveguide losses their maximum size is still limited to a few centimeters.The proposed project suggests the exploitation of a new type of electromagnetic waveguide in order to realize passive planar concentrators of unsurpassed collection efficiency, size, concentration, lifetime and costs. A dielectric TE1-mode shows a node, a position in the waveguide where no intensity is found. A thin film placed in this node remains largely “invisible” for the propagating mode. Such dielectric node modes (DNMs) have been investigated by the applicant in previous work, but only recently a silver island film (SIF) was for the first time placed in such a node. The resulting extremely low waveguide losses cannot be explained by our current understanding of waveguide modes and hint to a hybridization between the SIF-bound long-range surface plasmon polaritons (LRSPPs) and the DNMs into what we call hybrid node modes (HNMs). The SIFs strongly interact with incident light. An appropriate nanopatterning of SIFs enables efficient excitation of low-loss HNMs modes collecting solar power over square meters and concentrating it. To achieve this goal new technological methods are used that enable patterning on the nanometer scale and low cost roll-to-roll processing at the same time. New measurement techniques and numerical simulation tools will be developed to inv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Therapeutic Allele Engineering: A novel technology for cell therapy' (TALE), addressing dissemination and exploitation.

assistant: **Impact**

We are currently witnessing a revolution in cell therapies that are routed in decades of basic research in genetics, cell biology and immunology. A deep understanding of mammalian, and in particular immune, cells is currently being translated into highly efficient cell-based therapeutics. Technologic breakthroughs in genetic and genome engineering are further fueling the generation of customized, high precision therapies that are based on cells as “smart drugs”. For instance, reprogramming immune killer cells to recognize B cell leukemias resulted in unprecedented clinical responses in treatment-resistant and relapsed patients. However, currently only very few, highly selected patients benefit from these developments. A fundamental problem of today’s cell therapies is that transferred cells cannot be distinguished from host cells. We have developed “allele engineering”, a new technology that solves this challenge. Here, we outline how allele engineering will improve the safety and efficacy of cell therapies. We will 1) generate a non-viral, DNA-free safety/shielding switch 2) develop a radically new curative approach to acute myeloid leukemia 3) rationally design a safe allele engineering solution for human therapy and 4) use allele engineering as a curative therapy of scurfy syndrome, a lethal monogenic autoimmune disease. Allele engineering enables completely new treatment strategies and can be applied to any surface protein. Therefore, I anticipate that the results will have a major impact on the field.


**Keywords:** Cell therapy, CAR T cell, safety switch,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European Union Contest for Young Scientists' 2017' under Horizon 2020.

assistant: **Concept**

European Union Contest for Young Scientists (EUCYS) has been organized since 1989 with the aim of promoting science and research among Europe's youth and bringing together the talented young people across Europe. The young scientists also have the chance to meet others with similar abilities and interests and to be guided by some of the most prominent scientists in Europe. This way EUCYS seeks to strengthen the efforts made in each participating country to attract young people to careers in science and technology. EUCYS has been organized in countries across Europe with the aim of promoting science and research in different countries and bringing research and young talents into spotlight in these countries. Estonia will organize EUCYS for the first time in 2017, but has previous experience in organizing Estonian National contest since 2002 and a Young Scientists Festival with format similar to EUCYS since 2015. The host organizer of EUCYS 2017 will be Estonian Research Council (ETAg) in close cooperation with Estonian Ministry for Education and Research, Estonian Academy of Sciences and Tallinn City Council.EUCYS brings together excellent young researchers from 40-69 countries. During 4 days the participating projects will be interviewed by jury members and decisions about European Union prizes, special prizes and host organization prizes will be made.  Some opportunities will be offered to EUCYS participants to get acquainted with Estonian research and Estonian teachers and young researchers will be offered opportunities to meet EUCYS participants.


**Keywords:** European Union Contest for Young Scientists' 2017 Tallinn Estonia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Multi-Scale Complex Genomics'.

assistant: **Concept**

Genomics is probably the fastest evolving field in current science. A decade ago our main concern was to obtain the sequence (the 1D code) of the genome; but today the big challenges are to determine how genotype information is transferred into phenotype, and how pathological phenotypic changes can be predicted from genome alterations. While investigating these points, we have realized that a part of the regulation of gene expression is implicitly coded in the way in which chromatin is folded. As technology has advanced and information of the folded state of chromatin has emerged, a new branch of genomics (3D/4D genomics) has emerged. Hundreds of laboratories are now defining a young and active community that, though in the end concerned with the same scientific problem, uses many different approaches to study it that individually target radically different length and timescales. The community faces severe practical problems related to: i) how huge, noisy, and diverse data related to widely different size and time scales can be integrated, ii) the lack of standardized analysis and simulation tools, iii) the complete disconnection of associated informatics databases, and iv) the lack of validated and flexible visualization engines. MuG is born at the critical point in the evolution of the field, in a bottom-up approach from the biologist who are suffering severe IT problemes. MuG, supported by European leaders in the field, join three different expertise: biologist with interest in chromatin structure, methods developers and HPC facilities with strong history of supporting Bio-computational problems. We believe that MuG will be a steep-forward in approaching the potential of High Performance Computing to the development of 3D/4D genomics, and will contribute to give a st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Rebuilding the human thymus to create a tolerising system for allogeneic tissue and organ transplantation' (Rethyming).

assistant: **Concept**

Organ transplantation has revolutionized medicine as it became possible to replace an irreversibly diseased organ. However, the immune suppressive therapy to avoid rejection is associated to life-threatening complications. Finding a way to selectively induce tolerance to donor antigens, while maintaining immunity to pathogens and cancer antigens would represent a major breakthrough in medicine with the achievement of immunosuppression-free organ transplantation. During development and early life immune T cell competence and central tolerance are specified in the thymus; thus I aim to dissect the complexity of this organ by rebuilding it in a controlled fashion ex vivo. In a first step, a natural scaffold will be prepared from fresh human and animal thymi by perfusion decellularization; subsequently cultivated human thymic epithelial cells (TECs) will be used for re-epithelialization of the a-cellular scaffolds. Finally, immature lymphocytes from an HLA-mismatched donor will be delivered to the thymus-scaffolds through the preserved vascular extracellular matrix structures and cultured in a customized bioreactor in optimized conditions for T cell differentiation and tolerance induction. Detailed phenotypic and functional analyses will be performed to identify the frequency of mature T cell subsets, including Tregs, and assess the level of tolerance to the HLA antigens expressed by TECs. Finally, the possibility of re-epithelializing scaffolds with pig TECs will allow testing its interaction in vivo in the context of organ transplantation, providing the very first proof of principle that it may be possible to achieve antigen-specific tolerance and avoid rejection without the need for generic immunosuppressive therapy.Overall, this project takes a multidisciplinary approac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Identification, evaluation and revival of the acoustical heritage of ancient theatres and odea' under Fifth Framework.

assistant: **Concept**

The Greek and Roman theatres are among the most precious and spectacular items of cultural heritage in the Mediterranean countries. The main objectives of this research are identification, virtual restoration and revival of the acoustical heritage in a few, selected examples of the theatre and the roofed odium in a 3Dvirtual environment. The virtual restitution will integrate the visual and acoustical simulations, and will be based on the most recent results of researching archaeology, theatre history, clothing, performance and early music. The innovative elements in this project include a new technique for simulation of moving sound sources, i.e. the players, chorus and musicians, and the integration of visualization and naturalization. The simulation tool developed in this project will also serve as a basis for recommendations for the modern use of the old performance facilities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Emergence of high-mass stars in complex fiber systems' (EMERGE) targeting Horizon 2020.

assistant: **Abstract**

High-mass stars drive the physical and chemical evolution of the Universe. However, the origin of these massive objects is largely controversial. Three key questions remain under debate: a) Which physical processes determine the formation of high-mass stars? b) How do these stars get their large masses? c) Do high-mass stars form in a similar way to their low-mass counterparts? Galactic surveys link the origin of high-mass stars to the initial properties of their gas embryos. Using the Atacama Large Millimeter Array (ALMA), I recently proved the existence of a new and fundamental filamentary organization of the gas within the Orion Nebula, the nearest high-mass star-forming region. After leading this key discovery, I propose to investigate the formation of high-mass stars as an emergent process in complex systems. In this novel scenario massive stars are created naturally by the internal interactions within networks of filaments of increasing density. To fully characterize this ground-breaking approach, this project will carry out the first systematic study of (1) the substructure, (2) internal interactions, and (3) dynamical evolution of these filamentary systems across the Milky Way.EMERGE will survey a homogeneous ALMA sample of >30 massive filamentary networks, the largest of its kind, extracted from the first intensive exploitation of its public archive. These observational results will be tested against state-of-the-art simulations using a new generation of analysis tools. The ultimate goal of this project is to statistically quantify how unique multi-scale phenomena generated in these filamentary systems, such as collisions, mergers, and self-gravity, determine the initial conditions for the formation of high-mass stars. This ERC-StG project will solve a current
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DAMA-BIOX: Breaking the link between obesity-related inflammation and oxidative stress by bioavailable compounds from apple pomace delivered in novel dairy beverages', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Overweight and obesity are risk factors for cardiometabolic diseases that can be partially prevented by adopting healthier lifestyles and eating habits, such as increased fibre intake and other bioactive compounds, such as phenolics. However, in the European Union, the proportion of overweight adults varies from 37 to 73%, averaging 53%. DAMA-BIOX uses apple pomace (AP) to recover, purify and encapsulate phenolic compounds (APF) and fibres to unveil the mechanisms of antioxidant and anti-inflammatory properties of the bioavailable fraction in 3T3-L1 adipocytes challenged with supraphysiological concentrations of palmitic acid to simulate obesity. DAMA-BIOX implements the use of an innovative humanised three-dimensional co-culture intestinal barrier model consisting of human enterocytes (Caco-2) and human fibroblasts (CCD-18Co) to recapitulate human intestinal absorption. The use and reuse of AP also target sustainable food production by harnessing agro-industrial side streams, representing a tangible solution to produce functional foods. DAMA-BIOX addresses this aim across four work packages, contributing to the environment, agroindustry’s circularity, and public health. DAMA-BIOX brings together cross-sectoral expertise, strengthens the European capacity for healthier and sustainable innovations, and generates new possibilities for food export. The prestigious fellowship will provide the experienced researcher (PF) with the first step in a new research field that will act as a platform to kick-start the future international academic career. The University of Limerick is the place of renowned subject experts, and exposure to international collaborators will provide the PF with a unique opportunity to grow as an independent researcher.


**Keywords:** food science,  zero