RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multilevel inflammatory regulation in cardiometabolic disease' under Horizon Europe.

assistant: **Concept**

The benefit of targeting inflammatory pathways in cardiometabolic disease on top of traditional healthcare and medication is evident from recent clinical studies. However, generalized blocking of inflammation also impacts on patients’ defense against infections and other immune-associated pathologies, such as cancer. Clearly, more precise interventions that target disease-specific cellular subsets and mechanisms are eagerly awaited. MIRACLE’s focus on innovation is to pave the way to precision medicine by deploying and valorizing current technological breakthroughs for a detailed definition and targeting of cardiometabolic disease-associated and causative cellular subsets. MIRACLE is inspired by latest advances in single cell biology, multi-omics analysis and newest insights in macrophage biology. These advances revealed heterogeneous and dynamic accumulation of (immune) cell populations in tissues that associate with disease initiation, development and particularly clinical outcome, a notion that has immense implications on our view of chronic inflammatory diseases and their treatment. Unique know-how is ready to be transferred to highly talented fellows. In MIRACLE, twelve young scientists will receive tailored training that enables them to study local and environmental factors that drive cardiometabolic inflammation as well as develop strategies to suppress them, via the integrated use of cutting-edge single cell, spatial mapping, computational and disease modeling approaches. Moreover, they will be able to develop and polish skills in translational science by working with biotech- and pharma experts and clinicians pledging clinically actionable outcomes. The combination of high-level science with top-notch infrastructures, resources, and solid data places MIRACLE at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Revolutionizing diabetes management by combining in silico models and AI control for vagus neuroprostheses' (DiabetManager) under Horizon Europe.

assistant: **Objectives**

Diabetes is a major world health problem, approaching epidemic proportions and causing long term health damages due to inappropriate blood glucose regulation. Pharmacological therapies are limited by numerous side effects (as renal insufficiency or heart failure) and dose management issues. Their efficacy is also hindered by often problematic, patients’ compliance. This results in an unmet need for automatized, closed-loop glucose metabolism regulation, adaptable to variable patients’ conditions. Vagus nerve (VN) is a major component of the autonomous nervous system innervating internal organs, and its electrical stimulation showed preliminary results in modulating glucose metabolism. However, underlying mechanisms remain unknown, posing a high-risk to its feasibility, and could lead to indiscriminate stimulation causing multiple side effects (compromising breathing or heart rate). Fine glucose regulation cannot be achieved without better understanding of nerve-implant interaction and circuits stimulated by VNS. I aim to fill present scientific gaps by developing the first VNS neuroprosthesis for personalized closed-loop-regulation of glucose levels in diabetics.  This results in a significant challenge: defining stimulation policies able to selectively block or activate specific neural pathways, while counteracting metabolic shifts and implant-nerve alterations. To that aim I will exploit models-driven interface design and AI-based stimulation policies. Animal experiments will investigate the physiological responses to optimal policies, maximising glucose regulation while minimizing adverse events, inspecting both cervical and abdominal VNS. Optimal VNS will be validated in human trials achieving device assessment in patients. DiabetManager will shed light on the under
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Researchers' night 2006: Portraits in the Hexagon' under Sixth Framework.

assistant: **Concept**

For the second Researchers' night", 9 partners from the "French Hexagon" want to share their human and scientific richness. Thus researchers working in French universities and research centres will be at the core of the events during the evening of the 22nd of September 2006, in 11 towns in France. Music and theatre events, offered by researchers themselves, will make the public discover that these sometimes "unreachable" persons are in fact people like any other.Meetings with researchers in unusual place s, such as cafés, pubs or historical buildings, will demonstrate that researchers are among usual customers. Workshops and original museum visits will open the doors to understanding daily scientific work. Viewings, discussions and debates will allow anyone to express himself about the image of researchers and their role in our everyday life. Some special activities will be provided for young people and children to help them discover, beyond the myth, the real face of science makers.In order to exalt multiplicity and complementarity of researchers throughout France, an 18-portrait exhibition will be offered simultaneously by each of the 9 partners. In this exhibition, 18 researchers from the 9 partners will be photographed and will explain the sense of their researcher's life. A special attention will be paid to making the diversity of the researchers visible, with different topics, but also different ages, sexes, origins or "curriculum vitae" being represented.Most of these researchers will participate to activities during the events of the night, making them accessible for the public in parallel of the exhibition. A common graphic design will be created by the coordinator in order to provide a visual homogeneity all around the French territory for the communication c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development and enhancement of laboratory networks for avian influenza' in the context of a Sixth Framework call.

assistant: **Objectives**

Currently, within the European Union, a largely informal communications system exists between the avian influenza (AI) national reference laboratories (NRL's), coordinated by the community reference laboratory (CRL). The current global H5N1 crisis has resulted in a significantly increased demand for laboratory capacity and capabilities for AI diagnosis and surveillance.The exponential growth in AI work has highlighted the benefits of closer collaboration within the network that we propose to address. Spread to humans has also highlighted real concerns of the pandemic potential of H5N1, reinforcing the need for closer integration between veterinary and public health laboratories. FLU-LAB-NET, provides new opportunities for enhancement and reinforcement of the CRL and NRL networks within the EU, facilitating improvements and harmonisation of laboratory and diagnostic methods, coordination of research efforts, data exchange, as well as development and sharing of expertise.Rapid responses to national and global emergencies with data sharing will be key areas of exploitation, leading to a European laboratory task force capability for AI in animal species. Rapid and formal interactive communications will be addressed through the application of web-based forums. The envisaged network will also encompass participation of laboratories involved in influenza research in domestic mammals and foster formal links and coordination with corresponding human, swine and equine influenza networks. FLU-LAB-NET provides a vision of enhanced interactions, identifying and developing the complementarities of global, multi-disciplinary influenza research programmes.Strategically important Third country and INCO partners are also included in this network, in order to raise laboratory standards an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Interknow' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The subject of the project focuses on the interaction between different European cultures, especially among EU-member states and the accession-candidates, in the process of EU enlargement and enhanced political, social and economic relations. The European Union of the future will be a union of people with a vastly increasing variety of cultural-backgrounds, identities, traditions and values. Interaction between different cultures and value-systems might sometimes cause difficulties because of a lack of intercultural knowledge and awareness of the special features of other cultures. Moreover, Europe has to exploit its resources better which come from its cultural diversity. Intercultural training of European students and researchers of economics, management and political sciences is regarded to be crucial to enhance competitiveness of European corporations, firms and institutions. The field of research is Intercultural Knowledge (IK) and Intercultural Knowledge Management (IKM). The socio-economic reason for the project is to improve transfer of intercultural knowledge and Intercultural knowledge management within firms and corporations, which act on a European or even global level. It is the scientific reason and aim of the multi-disciplinary team of scholars to deepen and widen our knowledge about the core issues in an increasing variety of cultural interaction, in order to develop new tools and concepts for training and education focus, especially the fields of politics and business), to establish a common European concept of IKM, which can help people to understand that intercultural knowledge and intercultural knowledge management are important resources which enhance global competitiveness of Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'GLAss and Metal mutual (biO)-coRrosiOn : conservation of mUseum collections in Storage.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

In the field of Heritage conservation, the long-term preservation of archaeological and historical objects held in deposits is a subject of increasing concern. Artifacts made from two or more different materials in contact with each other, often stored under uncontrolled environmental conditions of temperature, humidity and clearness, can undergo degradation faster than thought. The contact areas and interstices between two materials are especially critical points for joint degradation phenomena and prolific ground for microbiological contaminants, especially in conditions of high humidity and in presence of organic pollutants. With this in mind, I am herein proposing an innovative project to investigate the degradation processes and microbiologically-induced corrosion of glass-metal objects that can occur in museum storage environments. I will capitalize on my own experience in Heritage science and glass alteration mechanisms, and on the competences and skills of the host institutions in electrochemistry and microbiologically induced corrosion to i) identify the major glass-metal joint corrosion phenomena and the microbiological contaminants present in museum storage deposits, ii) investigate the mechanisms underlying glass-metal corrosion and biocorrosion mechanisms by performing laboratory corrosion tests, and iii) experiment the application of electrochemical impedance spectroscopy (EIS) to monitor the previously described corrosion mechanisms. The proposed project will advance the understanding of joint (bio)-corrosion processes occurring at the interface between glass and metallic materials and will hopefully establish a new methodology to monitor such mechanisms. I will be extensively trained in corrosion processes and electrochemical techniques, microbial proces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unravelling the role of lysine acetylation in the regulation of glycolysis in cancer cells through the development of synthetic biology-based tools' under Horizon 2020.

assistant: **Concept**

Synthetic biology is an emerging discipline that offers powerful tools to control and manipulate fundamental processes in living matter. We propose to develop and apply such tools to modify the genetic code of cultured mammalian cells and bacteria with the aim to study the role of lysine acetylation in the regulation of metabolism and in cancer development. Thousands of lysine acetylation sites were recently discovered on non-histone proteins, suggesting that acetylation is a widespread and evolutionarily conserved post translational modification, similar in scope to phosphorylation and ubiquitination. Specifically, it has been found that most of the enzymes of metabolic processes—including glycolysis—are acetylated, implying that acetylation is key regulator of cellular metabolism in general and in glycolysis in particular. The regulation of metabolic pathways is of particular importance to cancer research, as misregulation of metabolic pathways, especially upregulation of glycolysis, is common to most transformed cells and is now considered a new hallmark of cancer. These data raise an immediate question: what is the role of acetylation in the regulation of glycolysis and in the metabolic reprogramming of cancer cells? While current methods rely on mutational analyses, we will genetically encode the incorporation of acetylated lysine and directly measure the functional role of each acetylation site in cancerous and non-cancerous cell lines. Using this methodology, we will study the structural and functional implications of all the acetylation sites in glycolytic enzymes. We will also decipher the mechanism by which acetylation is regulated by deacetylases and answer a long standing question – how 18 deacetylases recognise their substrates among thousands of acetylated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Creating Actionable Futures', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The CrAFt project will place the transition to climate neutrality at the heart of urban stakeholders. We will support the Mission Board on Climate-Neutral and Smart Cities and the H2020 LC-GD-1-2-2020 one-stop platform in designing and deploying Climate City Contracts, based on experience-based knowledge from CrAFt’s 3 Sandbox Cities (Bologna, Prague and Amsterdam) and 70 Reference Cities engaged in testing and sharing knowledge together with cultural, artistic and creative sectors, property owners and tenants, and citizens and communities. We will deliver a “Climate-Neutral and Smart Cities Guidance Package: NEB Edition” featuring at least 160 collaborative local governance models, tools, examples or stories. This will be supported by a NEB-inspired impact model that helps cities to harness the value of inclusiveness, aesthetics and sustainability, as understood within the local contexts of their city, in their transformation towards climate neutrality, in at least 80 local emblematic projects. More than 30 European universities and schools of arts and design will be engaged in supporting their local cities, with more than 100 students engaged in STEAM teams, internships and local capacity building. We will deliver at least 6 policy briefs informing European policy and programmes about the learnings of these activities, and a storytelling campaign to co-create positive and inclusive narratives towards climate-neutral futures, for, with and by citizens and communities. Together, we will create actionable, climate-neutral futures across Europe by supporting the deployment of NEB-inspired collaborative local governance models, leaving no one, and no place, behind.


**Keywords:** collaborative governance models, societal impact, STEAM teams, storytelling campaign, next-ge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mechanised Reverse Mathematics in the Calculus of Inductive Constructions' in the context of a Horizon Europe call.

assistant: **Objectives**

“Foundations of mathematics” labels the centuries-old interdisciplinary vision to secure the logical basis for mathematics and its applications. Gödel's celebrated completeness theorem for first-order logic, identifying semantic truth with syntactic deduction, is a key result heralding the formal phase of that vision. Yet, this and other foundational results have not been fully characterised regarding their logical strength and computational content, limiting their understanding and applicability.The MeReMath project aims at closing this gap by systematically employing computer mechanisation to the programme of reverse mathematics, the ongoing effort to identify the exact logical principles underlying completeness and other results. For this analysis, the project will use the calculus of inductive constructions (CIC) as a logical base system, embodying an agnostic intuitionistic base system unveiling fine logical structure, and the Coq proof assistant, an interactive software tool for modelling logical reasoning and its computational content.Specifically, continuing previous research of the experienced researcher (ER) and the supervisor, the MeReMath project will contribute the first comprehensive constructive and computational analysis of the completeness theorem, taking into account all dimensions relevant to its logical strength and implementing modularly mechanised proofs as executable Coq code. By further accommodating a similar analysis of the related Löwenheim-Skolem theorems and other results in the canon, the main outcome of the MeReMath project will be a well-designed, collaboratively developed Coq library for (constructive) reverse mathematics, with novel logical observations and mechanisation techniques developed on the way.Hosted at the IRIF lab in Paris, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'NEARshore geological CONTROL on coastal morphodynamics: monitoring and modelling in high-resolution'.

assistant: **Objectives**

A major shortcoming of contemporary coastal research is the poor quantification of geological control in nearshore hydrodynamic and morphosedimentary processes along natural and developed coastal areas. This is particularly relevant given the global dominance of geologically-constrained coastlines, which face increasing risks driven by extreme storm events and growing societal pressures on the coast. This project aims to advance the knowledge of beach and nearshore morphodynamics within complex geomorphological settings, dominated by multi-dimensional geological control. The fundamental objective is to quantify the role and impact of nearshore geological control under energetic conditions. This will be accomplished by developing a ground-breaking approach, based on state-of-the-art surveying and monitoring methods to acquire unprecedented geophysical, morphological and hydrodynamic information of the beach and nearshore zones in geomorphological complex settings. New-generation process-based modelling will be implemented to explore wave-driven currents and patterns of sediment transport under realistic settings and conditions. Linking the sedimentary and geological framework of the beach and nearshore with field measurements and numerical modelling constitute a novel approach that will lead to fundamental advances in coastal geomorphology, further improving the ability to predict storm-induced erosion in geologically-controlled settings. To bring together these embedded scales of analysis and innovative approaches, this project is based on collaboration with international-leading experts in coastal geomorphology, marine geology and geophysics and coastal modelling. Expertise and skills developed by the fellow will contribute to an internationally-leading academic and re