RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fast and Reliable Excited State Hypersurfaces with Orbital-Optimized Density Functional Theory' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Modeling light-induced processes is a complex task, but understanding and exploiting them enables employing the absorbed energy in transformations. Yet, no electronic-structure method combines high accuracy with low scaling, limiting the size of the systems investigated in molecular simulations. This project will advance state-specific methods based on density functional theory (DFT), improve the calculation of the excited-state potential energy surface (PES), and apply them to the direct calculation of experimental observables in molecular simulations.During the outgoing phase at UC Berkeley, under the supervision of Prof. Martin Head-Gordon, I will develop electronic structure methods to accurately model atomic forces and structures with orbital-optimized density functional theory (OO-DFT). The OO-DFT PES is corrected in the crossing regions with the non-orthogonal configuration interaction (NOCI) method, and the off-diagonal NOCI Hamiltonian elements approximate electronic couplings for energy and charge transfer. Furthermore, the transient-absorption spectra (TA) will be computed via time-dependent perturbation of the excited-state density, enabling direct comparison to time-resolved spectroscopy experiments. Each method development task will be validated by systematic benchmarking, and all reference sets will be deposited in open-access repositories.During the return phase at the Donostia International Physics Center, under the supervision of Prof. David Casanova, I will apply the excited-state methods I developed to photoactive systems of technological and biological relevance, including organic photovoltaics (OPV), organic light-emitting diodes (OLED), and photosynthetic complexes. The results will broaden our understanding of natural light-harvesting and acceler
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Geologic Carbon Storage' (CO2-REACT), addressing dissemination and exploitation.

assistant: **Impact**

The CO2-REACT ITN has been created to address twin objectives: (1) to provide urgently needed training in CO2 storage preparing candidates for critical roles in the coming years and (2) to significantly advance  our understanding of the fate and consequences of CO2 injection into the subsurface during carbon storage efforts.  The CO2-REACT ITN addresses these objectives through a balanced combination of 6 academic and 6 industrial teams. The academic partners have been selected for their unique and diverse expertise in the reactivity of carbonate phases at scales ranging from the atomic to the field scale.  The six industry partners were selected to represent a spectrum of the largest stakeholders in CO2 storage. By formally joining these teams, we are creating a training/research platform that is unique in the world in its ability to understand the fate and consequences of CO2 injected into subsurface reservoirs using an impressive array of experimental and modeling techniques.CO2-REACT aims to train 13 ESRs and 1 ER, through an integrated and coherent set of research and training activities that will significantly improve our understanding of the consequences of injecting CO2 into the subsurface.  We chose this technical focus because: (1) new knowledge is essential for solving a critical societal problem, (2) the problem is interdisciplinary, requiring input from chemistry, geology, physics, chemistry, hydrology and engineering, (3) producing solutions that industry can implement will promote tight academia-industry collaboration, a true plus for the trainees and and 4) by focusing on a single theme, close interaction and collaboration among the CO2-REACT teams is fostered. An additional societal objective of CO2-REACT is help to raise public awareness to the needs,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Validation of treatment decision algorithms for childhood tuberculosis at low levels of healthcare in high burden countries - effectiveness, implementation, and integration into policy and practices'.

assistant: **Objectives**

Childhood tuberculosis (TB) remains globally underdiagnosed and untreated. In 2022, WHO conditionally recommended the use of treatment decision algorithms (TDAs) to improve the diagnosis of pulmonary TB in children <10 years and called for the external validation of two suggested TDAs for children. The Decide-TB project aims to generate evidence for the implementation of a comprehensive TDA-based approach for TB in children living in high-burden, resource-limited countries, at district hospital and primary health centre levels, and to facilitate the integration of this evidence into practice and policy. As an interdisciplinary consortium of researchers and national TB programs (NTPs), we will conduct a programmatic pilot of WHO-suggested TDAs, also integrating specific TDAs for children living with HIV and/or those malnourished, and severity assessment for shorter treatment decision in non-severe TB disease. Clinical mentoring tools and a Clinical Decision Support System will be developed. District information systems will be strengthened to collect individual data for program monitoring and supervision by NTPs, and for research. The TDA-based approach will be tested in a pragmatic stepped wedge cluster-randomized trial, including effectiveness, implementation, socio-behavioural, economics and policy research components. The diagnostic accuracy of TDAs will be assessed in a parallel meta-analysis of children with presumptive TB from recent studies led by consortium members. The pragmatic trial and meta-analysis will contribute to external validation of the WHO-suggested TDAs. Engagement of key stakeholders and decision-makers throughout the project will support adoption into international and national policies and into clinical practice. Through validation of TDAs, wide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Discovering and exploiting hidden pockets at protein-protein interfaces' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Protein-protein interactions play critical roles in normal human physiology, as well as in numerous diseases such as cancers and neurodegenerative disorders. However, identifying small molecule drugs to block protein interactions is a very difficult task. One of the major difficulties is that often the proteins involved are extremely flexible and readily change shape, which greatly complicates efforts to find small molecule ligands of matching shape. In this project, we aim to exploit protein flexibility to create new opportunities for drug discovery.Interactions between a given pair of proteins commonly requires one or both partners to transiently form pockets that allow selective binding. Therefore, most protein interfaces likely possess many more binding pockets than those apparent in the static picture of a protein structure revealed by crystallographic experiments. We propose to identify these ""hidden"" pockets using computational methods. Thus, we will develop and validate molecular simulation methodologies to detect hidden pockets at protein interfaces and assess their small molecule ""druggability"" using docking calculations and binding site scoring functions. Such capacity would greatly strengthen the reliability of in silico drug design. We will perform virtual screens to find small molecule ligands binding to hidden pockets in medicinally important proteins such as FcgammaRIIA or PCNA. Finally, we will purchase or synthesize promising ligands and assay their activity against protein targets. These studies will allow us to test the utility of our computational approach in rational drug design.The objectives of this research are part of a broader program we are currently developing and whose purpose is to provide a comprehensive set of computational/biophysic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Problems in Extremal Graph Theory' in the context of a Seventh Framework call.

assistant: **Objectives**

Graph theory is a modern branch of mathematics that has developed during the 20th century. Graphs allow us to model real life situations such as social networks, telecommunication networks or road networks. In order to fully understand which are the most relevent properties for graphs, one has to investigate how different properties of graphs interact. This is the core of extremal graph theory. One very natural question in the field is what parameters enforce the existence of a given particular subgraph. More generally, embedding problems seek sufficient condition a graph (or digraph) needs to have in order to contain a given subgraph. Roughly speaking Ramsey theory states that `complete disorder is impossible'. In many cases, this means that if a structure which is arbitrarily partitioned in several pieces, a specific substructure is completely contained in one of these pieces. Within the project, we aim to solve several important problems in the above areas using probabilistic techniques such as the Regularity lemma.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Unravelling cluster root development in white lupin' in the context of a Horizon 2020 call.

assistant: **Objectives**

Plant development is continuous throughout their lifetime and reflects their ability to adapt to their environment. This developmental plasticity is very obvious in the development of the root system. Surprisingly, the fundamental mechanisms of root development have been studied into great detail but the effect of the environment on its plasticity is still largely unknown. I will use phosphate, since this nutrient has a very low mobility in soil, as a mean to study plant developmental adaptation in white lupin.This species has developed extreme adaptive mechanism to improve phosphate uptake by producing structures called “cluster roots”. They are dense clusters of lateral roots with determinate development and highly specific physiology. I will develop new tools to identify cluster root mutants in white lupin, sequence white lupin genome, perform tissues specific transcriptomics and perform full molecular characterization of selected genes. This project will also lead me to compare adaptive mechanisms between white lupin and narrow-leafed lupin, a closely related species that does not produce cluster roots. We will also test whether it is possible to transfer the ability to form cluster roots in this species. Altogether, this project will lead to a major advance in our capacity to understand how plants are able to sense and respond to their environment and how evolution has selected adaptive developmental mechanisms to improve their capacity to use limited resources.This project focuses on the most extreme developmental adaptation produced in response to phosphate starvation. It is ambitious, as it will necessitate the development of several tools. However, it is highly feasible since it builds on my previous experience and important outcome can be expected in term of c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'EIT RawMatrials Business Plan 2023-2025' (2021-2027) under Horizon Europe.

assistant: **Objectives**

Metals and minerals are key enablers for the European Green Deal and will substitute fossil fuels in the long run. At the same time, Europe is highly dependent on importing raw materials for its manufacturing industries and to accomplish the transition to a resource efficient, sustainable society. This is why the European Green Deal defines access to resources as a strategic security question for Europe’s ambition to develop into a green economy. To meet this challenge, the vision of EIT RawMaterials is to develop raw materials into a major strength for Europe. EIT RawMaterials’ mission is to advance Europe‘s transition to sustainability by driving innovation along the entire raw materials value chain. To fulfil the mission, three strategic objectives are addressed: securing raw materials supply; designing materials solutions; and closing materials loops.EIT RawMaterials is the world’s largest and leading partnership in raw materials and closely connected with the policy agenda of the European Commission. The Knowledge and Innovation Community (KIC) is open to new partners from Regional Innovation Scheme (RIS) countries and small business and is driven by a strategy that creates industrial symbiosis through innovation across value chains. The European Raw Materials Alliance (ERMA) managed by EIT RawMaterials on behalf of the Commission is an important mechanism for translating projects into investments and infrastructures that contribute to creating added value and jobs for Europe within key strategic industrial ecosystems. These initiatives are complemented by EIT RawMaterials’ leading role in education and innovation activities, such as the EIT’s initiative in capacity building for Higher Education Institutions (HEI) and the European Commission’s European Innovation A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Integrated nanocomposites for thermal and kinetic energy harvesting' under Horizon 2020.

assistant: **Concept**

INTAKE (integrated nanocomposites for thermal and kinetic energy harvesting) is an inter/multidisciplinary research focused exchange and training programme that brings together researchers from various disciplines (engineering, physics and social science) with expertise spanning across energy harvesting, nanomaterials, micro/nanotechnology, functional composites, manufacturing and socioeconomic development. The network is specifically designed to foster an inter/multidisciplinary outlook in order to embed socioeconomic awareness and sustainability considerations within the research culture.INTAKE’s innovation vision aims to achieve a step change towards the next generation of hybrid energy harvesting nanocomposites, which can be integrated into lightweight and ultra-strong structural composites at the nanoscopic level. This would infuse composite laminates with inherent intelligent functionalities (such as energy harvesting, sensing and wireless communication), without noticeable alterations or adverse effects to the macroscopic structural properties. The resulting smart multifunctional composite material will have immense socioeconomic benefits to Europe and the world, as it can help to improve productivity and safety, while reducing operating costs and carbon footprint. This can then serve as a fundamental building block for numerous future engineering systems across the transport, energy, medical, space, utilities and infrastructure sectors. INTAKE consists of 4 European partners (in the UK, Hungary and Poland) and 4 Asian partners (in China and Japan). The network will help nurture the next generation of creative, highly skilled and socially responsible young researchers for the European innovation sectors. INTAKE will forge a mutually beneficial collaboration platf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Financing Festivals, Music and Theatre: Real Expenses and Fictional Expenditures in France between the Sixteenth and Seventeenth Centuries' under Horizon 2020.

assistant: **Concept**

How were court and civic festivities funded in the early modern period? This innovative, interdisciplinary project aims to shed light on an often disregarded aspect of the history of theatre and music: the economic realities of the production of public and private ceremonial and entertainment in early modern France. Scholars have tended to examine multiple aspects of such festivities (their allegorical meanings, political function, the artists involved, the birth of new theatrical and musical genres, etc.), but there is still no specific, systematic research that has dealt with quantifying the expenditure on such ephemeral cultural activities that could themselves be the subject of both blame (as a wasteful use of time and money) and praise (propaganda in favour of the sovereign, the state, and civic communities). The conventional view of festivities as a case of lavish conspicuous consumption is often supported by one set of sources reporting on it, such as printed descriptions, diary entries, letters, and so forth. But the information contained within these documents is usually determined by their function (official propaganda) or its sources (hearsay and gossip). Financial accounts of these festivities themselves, however, often present a different picture wherein expenses are carefully controlled and subject to prudent budget management. The gap between these “real” expenses and “fictional” expenditures is akin to the gap between reality and theatrical illusion; it also forces consideration of the professional world of artists and artisans—and the opportunities available to them—who created these festivities under taut economic and other constraints. The results of this pioneering survey, alongside with those already conducted by the ER on Florentine festival expens
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Life without mitochondrion'.

assistant: **Innovation**

Mitochondria are often referred to as the “power houses” of eukaryotic cells. All eukaryotes were thought to have mitochondria of some form until 2016, when the first eukaryote thriving without mitochondria was discovered by our laboratory – a flagellate Monocercomonoides. Understanding cellular functions of these cells, which represent a new functional type of eukaryotes, and understanding the circumstances of the unique event of mitochondrial loss are motivations for this proposal. The first objective focuses on the cell physiology. We will perform a metabolomic study revealing major metabolic pathways and concentrate further on elucidating its unique system of iron-sulphur cluster assembly. In the second objective, we will investigate in details the unique case of mitochondrial loss. We will examine two additional potentially amitochondriate lineages by means of genomics and transcriptomics, conduct experiments simulating the moments of mitochondrial loss and try to induce the mitochondrial loss in vitro by knocking out or down genes for mitochondrial biogenesis. We have chosen Giardia intestinalis and Entamoeba histolytica as models for the latter experiments, because their mitochondria are already reduced to minimalistic “mitosomes” and because some genetic tools are already available for them. Successful mitochondrial knock-outs would enable us to study mitochondrial loss in ‘real time’ and in vivo. In the third objective, we will focus on transforming Monocercomonoides into a tractable laboratory model by developing methods of axenic cultivation and genetic manipulation. This will open new possibilities in the studies of this organism and create a cell culture representing an amitochondriate model for cell biological studies enabling the dissection of mitochondri