RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Nanoscale Isotropic 3D Resolution using Omni-view Structured Light Sheet Microscopy'.

assistant: **Concept**

After spectacular advances in microscopy, a next leap is needed to enable biological studies at the deep sub-cellular scale of cells in their native multi-cellular tissue environment. Currently, it is impossible to image in 3D with isotropic resolutions below 100 nm over volumes larger than (100 micron)^3. I want to disprove the paradigm that there should always be a trade-off between resolution, imaging volume and sample longevity. Building on my track record in super-resolution microscopy, I propose a revolutionary optical architecture where the volume is illuminated and scanned sequentially using three tilted 2D light sheets that form three mutually orthogonal planes. These light sheets are created by illumination from both sides of the sample to form interference-based light patterns with fine 200 nm scale pitch. Together with new structured illumination image reconstructions this enables a 3D fully isotropic resolution twice as good as conventional light sheet microscopy. In a second conceptual advance, the patterned light sheets are applied in single-molecule imaging to achieve 3D isotropic enhanced localization precision at the 1 nm level, an order of magnitude better than current methods. The omni-directional illumination and imaging also enables refractive index tomography, leading to time and space-variant point spread functions. These are used in-silico in first-ever super-resolution image reconstructions that are fully adapted to volumetric sample heterogeneity. In a final step, the tomographic refractive index data is projected to spatio-temporal aberration maps that are fed into adaptive optics for dynamic correction of sample-induced aberrations to boost super-resolution imaging of live cells over extended times. The envisioned suite of information-optima
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Precise and non-GMO Engineering of Nutritional Factors for Breeding High Quality Crops' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

While great attention has been given to increase nutritional substances in food plants only limited efforts have been made for using biotechnology to reduce the level of endogenous, anti-nutritional factors (e.g. toxic compounds) in existing crops. Anti-nutritional substances not only affect the digestion and absorption of nutrients, but can also be lethal to humans or feeding animals and are responsible for food spoilage. Glycoalkaloids (GLAs) produced by crops of the Solanacea family, namely, potato and eggplant, are a major problem for breeders and farmers, as their level must be tightly regulated. Worldwide, between 13 and 27% of the potato crops are discarded because GLA levels are above the maximum currently deemed to be safe. In this PoC project we propose to redesign the potato GLAs metabolic pathway in a precise manner without the insertion of foreign genes, through targeted gene knockouts. Our strategy will be based on the discovery and intellectual property of genes part of the GLAs biosynthetic pathway obtained in the course of the ERC SAMIT project (Aharoni lab; ID-204575) that will be targets for precise, non-GMO metabolic engineering of potato. Know-how from TRACTAR, an ERC project (ID-268646) in the collaborating lab (A. Levy), will serve as the base for generating custom-designed nucleases (i.e. CRISPR/Cas) to be employed for targeted knockouts of potato GLAs genes. We will develop new potato cultivars with low GLAs content and with minimum impact on other plant characteristics, providing a proof-of-concept for potato breeding. In parallel to the technical testing, we will build a strategy to commercialize the IP and prototypes that have been or will be developed in the course of this project. We will identify and contact the relevant partners or invest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Cergop-2, a multipurpose and interdisciplinary sensor array for environmental research in central europe'.

assistant: **Concept**

We propose to extend and update existing hardware and Software facilities in 14 countries of Central Europe to an interdisciplinary multi-Purpose GNSS sensor array for environmental monitoring. Data acquired during the last 8 years will be supplemented by this proposal, which ensures monitoring during the next decade. Primary products are weekly coordinates and hourly zenith delay estimates and discrete values for epoch stations. Analysis of long term coordinate time series allows for the monitoring of crustal movements, the derivation of velocity fields and of geo-kinematic models and strain fields. Sub-regional campaigns investigate seismic active regions for hazard detection and possible mitigation. Hourly zenith delays act as a possible input for European weather forecast models. A by- product for public use are data for real-time navigation and precise positioning, a web-based seamless data bank will report on the results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The changing relationships between digital technologies, DNA and evidence'.

assistant: **Objectives**

The relationship between digital technologies, DNA and evidence is changing so rapidly and profoundly that in-depth and creative analyses of the links between them are urgently needed. Digital innovations within forensic DNA analysis affect the making of DNA evidence. For example, new computer programs create identikit pictures from DNA. At the same time, DNA and evidence-based reasoning also change digital technologies, for example when DNA is used as a storage medium for digital data. Digital DNA provides pioneering empirical insights and theorization on the reciprocal influence of digital technologies, DNA and evidence. The project defines an emerging field: the digitization of forensic biology and the influence of the biosciences on digital technologies. It provides systematic interdisciplinary studies on three sets of developments.  1. Changes in hardware. It investigates how smaller and more mobile hardware influences the production of DNA evidence, and how DNA is used as hardware in computing.  2. Changes in databases and analytic instruments. It studies how a growth in DNA databases and their algorithmic analysis influence the production of DNA evidence, and to what extent digital databases and algorithms are associated with evidence-based reasoning. 3. Changes in information per se. It discusses how the ability to alter DNA influences the production of forensic evidence, and how DNA influences the concept of digital data.   Current debates tend to focus on ethical, legal and societal aspects of forensic innovation or on the roles that big data and algorithms play in society. Digital DNA focuses on more fundamental developments: how DNA evidence changes when it is integrated with digital technologies, and the re-orientation that digital data and technologies und
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Strategies of circular Economy and Advanced bio-based solutions to keep our Lands and seas alIVE from plastics contamination', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

SEALIVE aims at demonstrating innovative circular strategies for bio-based plastics in land and sea applications. The project will be driven by economically and technically sustainable business models based on materials with advanced properties, design for circularity techniques and end-of-life solutions. It will establish a partnership of raw material providers, convertors, end users, recyclers, policy experts, certification organizations and NGOs to demonstrate solutions within a shared vision for circular plastic strategies. Solutions for reusable, recyclable and biodegradable bio-based plastics to prevent and significantly reduce marine pollution of all kinds will be demonstrated in four pilot territories: Cyprus, Ireland, France and Denmark (or Non-European site).  Innovative formulations based on PHAs, PLA and starch materials with advanced properties will be developed following recycling, biodegradability (marine and land) and composting standards. Design for circularity techniques (recyclable multi-layer single packaging materials, digital materials for traceability) and End-of-life solutions (high precision NIR-based mechanical recycling, controlled biodegradation/composting in natural and industrial conditions) will be upscaled at TRL6.  Solutions will be applied to 8 end-applications with high potential for pollution reduction of soils and water media: rigid food containers, flexible packaging, agricultural films, fish crates, fishing nets and aquaculture mesh bags. Pre-normative research will be carried out to improve current standards for biodegradation, composting and recycling with regards to eco-toxicity, safety and influence of plastic ageing. Policy recommendations at EU and global level will be provided in order to build a common framework enabling po
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'RNA-mediated intercellular miscommunication: role of extracellular vesicle cargos in Amyotrophic Lateral Sclerosis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Amyotrophic Lateral Sclerosis (ALS) is a rare neurodegenerative disorder that primarily targets upper and lower motor neurons. The progression of the disease is mediated by altered intercellular communication in the spinal cord between neurons and glial cells. Intercellular communication, mainly happening through extracellular vesicles (EVs) is responsible for the horizontal transfer of proteins and RNAs to recipient cells. Recently, I proved that EVs released from ALS mutant astrocytes selectively induced toxicity in wild type motor neuron, thus reinforcing the notion that astrocytes exert toxicity in ALS disease propagation and suggesting EVs as mediators of toxicity. Although, multiple factors can play a role in motor neuron degeneration, recent evidences point toward a fundamental role for RNA and RNA-binding protein dys-homeostasis as crucial players in ALS pathogenesis. Therefore, the overarching goal of ExItALS is to characterize the astrocyte-EVs RNA cargos, -through RNA deep-sequencing (Aim1). This approach will be complemented by the use of high-resolution flow cytometry (secondment) to separate EV populations and determine which one(s) is(are) responsible for motor neuron toxicity (Aim2). The present research proposal is a synthesis of my interests in neurodegenerative diseases and my expertise in biochemistry and neurobiology. At the Host Institution I will greatly benefit from the scientific exchange with several PIs interested in RNA biology, particularly with my supervisor, whose skills in RNA-binding protein biology and bioinformatics analyses will perfectly integrate and consolidate my molecular and biochemical expertise. The MSCA-RI-IF will be instrumental to develop this initial hypothesis into deeper biological understanding of ALS and represent a cr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The role of chromatin in the long-term adaptation of plants to abiotic stress' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Abiotic stress is a major threat to global crop yields and this problem is likely to be exacerbated in the future. Therefore, it is very important to engineer crop plants with improved stress tolerance. A large body of research has focussed on the immediate stress responses. However, in nature stress is frequently chronic or recurring, suggesting that temporal dynamics are an important, but under-researched, component of plant stress responses. Indeed, plants can be primed by a stress exposure such that they respond more efficiently to the next stress incident. Such stress priming and memory may be particularly beneficial to plants due to their sessile life style. Typically, the memory of priming lasts for several days after the end of the stress. During the past few years, my group has initiated a molecular analysis of heat stress memory in Arabidopsis thaliana. Heat stress memory is associated with sustained gene induction and transcriptional memory and we have demonstrated that this involves lasting chromatin changes. The underlying molecular mechanisms, however, remain poorly understood. Here, I propose to combine mechanistic dissection of heat stress memory in A. thaliana with concomitant translation of the results into the temperate cereal crop barley. In particular, we will study the following questions: What is the role of chromatin during heat stress memory? How do the transcription factors involved mediate memory-specific outputs? How does nucleosome positioning affect heat stress memory? How do histone modifications during stress memory interact with transcription, chromatin and nuclear organization? Is heat stress memory conserved in temperate cereal species? Can we engineer plants with improved stress memory? Using existing tools and new methodologies, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'An unrivalled medical device for severe cancer treatment complications:exact & easy red-LED photobiomodulation for mucositis and dermatitis'.

assistant: **Innovation**

Today the healthcare system is under great pressure due to the increasing incidence of cancer, which is also affected by ageing of the population. However, all efforts in the medical industry have concentrated on early diagnosis and treatment of cancer, so that this is becoming a chronic disease. The surfacing challenge from now on will be improving the quality of life of cancer patients. Mucositis and radiodermatitis are the most common and most debilitating side effects suffered by cancer patients but, so far, there is no approved preventive or curative treatment. In the last years, photobiomodulation has gained traction but the technology is still expensive, complex and inaccurate. CareMin650 is an innovative LED-based phototherapy device that will make photobiomodulation for the treatment of these conditions accurate, easy and inexpensive, thanks to its flexible fabric made of woven optic fibre. Neomedlight is proprietary of this core technology and knows a previous market success across Europe applying it to the niche market of jaundice treatment with Bilicocoon®. We now have validated the reliability of CareMin650 to deliver a fast, comfortable and painless treatment for patients; these are the added values to our central value proposition: a system for preventive and curative delivery of an accurate dose of red light. Moreover, this is a cost-effective solution to increase the quality of life and the survival of cancer patients: In the EU alone, CareMin650 will contribute to reduce the 200,000 cancer deaths and the €27.9 billion economic burden associated to mucositis and radiodermatitis. We have a huge untapped market ahead and now want to finalise CareMin650 development and achieve market preparedness. The SME Phase 2 project will allow NeoMedLight to put on th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mixed Spin Arrays of Reconfigurable Artificial atoms in Semiconductor quantum dots' (MiSARAS) targeting Horizon Europe.

assistant: **Abstract**

Most quantum simulation platforms are limited to spin S = 1/2 systems, preventing access to the rich physics of mixed-spin quantum matter. With MiSARAS I propose to develop the first solid-state platform for mixed-spin quantum simulation using gate-defined semiconductor quantum dots populated with multiple elementary charges to create artificial atoms with spin multiplicities exceeding 1/2. This innovative approach transforms multi-charge occupation, typically maintained at single occupancy, into a powerful resource for engineering programmable S > 1/2 ground states. Building on this idea, the project will systematically develop control over individual multi-charge quantum dots and extend this to coherent manipulation of quantum dot arrays with unprecedented connectivity. Key demonstrations of the platform capabilities will include realization of S = 1 Haldane chains exhibiting topological edge states, frustrated magnetism in competing interaction models, and mixed-spin systems combining S =1 and S = 1/2 sites. The proposed platform overcomes the fundamental limitations of fixed-spin quantum simulators and will provide unprecedented access to mixed-spin quantum phases predicted but rarely observed. The research will be conducted at QuTech, TU Delft, using state-of-the-art Ge/SiGe quantum dot devices and established theoretical collaborations. Expected outcomes include new experimental protocols for mixed-spin quantum simulation, fundamental insights into artificial quantum matter, and establishment of European leadership in the emerging field of quantum simulations. The platform's electrical control and semiconductor compatibility position it for integration into future quantum technology applications.


**Keywords:** Quantum Simulations, Quantum Dots, Spin Qubits, Quan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Comparative characterisation of oxidative stress in some congenital disorders with increased cancer proneness and early ageing' (1994-1998) under Fourth Framework.

assistant: **Objectives**

A number of congenital conditions include oxidative stress as a phenotypic hallmark, in spite of very distinct genotypic assets. These disorders include three rare, lifethreatening conditions, i.e. ataxia telangiectasia (AT), Fanconi's anaemia (FA), and xeroderma pigmentosum (XP), as well as two frequent congenital conditions, Down's syndrome (DS) and cystic fibrosis (CF). All of these disorders generate severe biomedical and social handicaps in their progression. A clinical feature shared by these disorders is cancer proneness, while other manifestations include early ageing, neurological symptoms or malformations. The onset of oxidative stress has been related to excess formation or defective detoxyfication of reactive oxygen species (ROS). This can arise from either the abnormal expression or inducibility of ROS-detoxyfying enzymes, or by defective absorption of nutrient antioxidants. Resulting oxidative injury has been characterised through: i. DNA, protein or lipid oxidative damage; ii. excess ROS formation (in vitro and ex vivo); iii. sensitivity to oxygenrelated toxicity, and iv. improvement of cellular defects by either hypoxia or antioxidants. Investigations conducted so far have focussed on individual disorders and have utilised a range of different methodologies; this has has lead to a number of unanswered questions regarding the role(s) for oxidative stress in these disorders. Thus, comparative studies are required which should focus on selected indicators for oxidative stress based on homogeneous methods, facilities and personnel. The ensuing information is expected to provide relevant insights into the pathogenesis of each individual condition, with possible consequences into the studies of ageing and cancer. Objectives: l. To evaluate some selected indica