RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multiscale analysis and hybrid simulations of neuronal microdomains: from molecular dynamics to function' (ADVANCEDMODNEURO) under Seventh Framework.

assistant: **Objectives**

Critical biological processes, such as cellular physiology or neuronal transmission have very different spatial scales are due to small binding sites inside or on the cell boundary, or narrow passages between large compartments. The great disparity in spatial scales can be resolved by singular perturbation analysis of their mathematical models.  Deriving the function of neuronal synapses from their molecular organization falls precisely in the class of problems associated with diffusion and it constitutes the inherent daunting hurdle of multiple scales. We propose here to construct mathematical models of neuronal microdomains, starting from the molecular to the cellular level and to develop stochastic modeling and singular perturbation methods for asymptotic analysis of the model equations, to use the analytical and numerical approximate solutions to extract properties from newly available molecular data and from Brownian dynamics simulations. A major application of the proposed molecular level modeling is the resolution of the spatiotemporal dynamics regulating neuronal microdomains and synapses. The results of this research will be methods in mathematical modeling, data analysis, asymptotic analysis, and in the designing of stochastic simulations of subcellular processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular and Genome Evolution of Prokaryotic Plasmids' in the context of a Horizon Europe call.

assistant: **Objectives**

Plasmids are autonomously replicating extra-chromosomal elements that play a major role in prokaryote ecology and evolution. The study of plasmid evolution has so far focused mostly on their biodiversity and effect on their host ecology and evolution. Nonetheless, the fundamentals of plasmid genome evolution remain to a large extent uncharted territory. Plasmids reside within a host cell that supplies their environmental, energetic and metabolic requirements. Consequently, natural selection operates on plasmids in two hierarchical levels: one component is the plasmid replication and inheritance within the host cell, and the other is the host fitness within the population. Studying the determinants of plasmid evolutionary success thus requires the expansion of classic population genetics theory to populations of plasmids within bacterial cells. The overarching aim of pMolEvol is to create a novel unified framework for plasmid molecular and genome evolution. This includes: 1) to quantify the effect of multilevel drift and selection on plasmid genetic diversity, 2) supply a framework for quantification of plasmid fitness and its effect on plasmid evolution, 3) characterize patterns and rate of plasmid genome evolution. Our conceptual framework will be based on empirical data from plasmid evolution experiments and reconstruction of past events from genomic information. The conceptually novel measures and approaches developed in pMolEvol open up avenues for the extension of classic population genetic theory to prokaryotic organisms. Across all domains of life, genetic information is stored, replicated and translated by similar mechanisms. Focusing on plasmids, we aim to uncover the general principles that govern the evolution of autonomously replicating genetic elements. Our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Integrating Novel matERials with scalable processes for safer and recyclAble Li-ioN baTteries' in the context of a Horizon Europe call.

assistant: **Objectives**

INERRANT aims to drive genuine advancements for safe-and-sustainable-by-design materials, and eco-friendly processes, to ensure the economical and widespread utilization of safer LIBs tailored for the expanding electromobility applications in our modern society. To realize this, INERRANT is formulating a holistic approach to enhance safety performance, extend cyclability and operational lifespan, and improve fast charging, all while maintaining cost-effectiveness, energy, and power density, and avoiding dependence on Critical Raw Materials. The pivotal S&T challenges encompass: development of functional materials, design sustainable recycling processes and understanding of pertinent interfacial phenomena and degradation mechanisms. The project addresses current challenges for LIBs components related to (i) novel (nano)materials combinations for anodes and cathodes; (ii) smart-functioning separators; (iii) stimuli responsive electrolyte formulations; (iv) novel sustainable recycling processes to improve the purity of recovered materials. Novel electrochemical characterization methods and operando spectroscopies, both at the materials and component level, will be utilized. This includes the establishment of a metrological framework for traceable calibrations and the integration of machine learning methodologies for swift and early LIB cell aging predictions. Adopting fabrication methods that are inherently scalable, built upon existing pilot lines and proven safety testing, will facilitate a swift progression to Gigafactory-relevant scales. INERRANT will present a compelling business case and clear exploitation strategy, rooted in the consortium’s strategic insight, guaranteeing effective technology commercialization. This approach will support the economical and eco-frie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SARS-CoV-2-induced activation of pathogenic endogenous retrovirus envelope HERV-W: towards personalized treatment of COVID-19 patients' (HERVCOV) under Horizon Europe.

assistant: **Objectives**

Severe COVID-19 disease and the high frequency of its long-term complications are now a major health problem worldwide. Due to the significant heterogeneity of COVID-19 disease profiles, biomarkers that allow either the identification of patients at high risk for developing severe forms of COVID-19 and its long-term complications, or guide personalized treatment options, are scarce. The HERVCOV project aims to analyze the role of human endogenous retroviruses (HERVs), known for their high pro-inflammatory potential, in the immunopathogenesis of COVID-19 and to identify and evaluate a set of biomarkers which will be important for the diagnosis, prognosis and follow-up of COVID-19 patients and their prioritization for targeted therapy. Recent data from the consortium has demonstrated that HERV-W envelope protein is highly expressed in lymphocytes of COVID-19 patients and correlates with inflammatory markers and respiratory outcome of the disease, strongly suggesting the role of HERVs in COVID-19 pathogenesis. The project aims to assess the biological pathways and functions that underlie the association of HERV expression and activation with severe COVID-19 forms and related complications. Biomarkers based on HERV pathogenic protein activation, SARS-CoV-2-specific immune responses, cytokine production and mandatory medical blood analyses for COVID-19 clinical monitoring will be studied in samples from different forms of COVID-19: acute, post- neuro- and long-COVID patients. Parameters will be determined that predict the clinical course of the disease and aggravation of SARS-CoV-2-induced symptoms and allow potential clustering of different bio-clinical profiles of COVID-19 patients. Diagnostic and prognostic panel(s) ?translated? from our fundamental research and subsequen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Decoding cell-to-cell variation in genome integrity maintenance' (DiVineGenoMe), addressing dissemination and exploitation.

assistant: **Impact**

Cells must ensure the integrity of their genome, and failure to do so can lead to mutations and cause disease. A sophisticated molecular network senses genomic lesions and coordinates their faithful repair with other DNA transactions, including transcription and DNA replication. Research over the last years has significantly advanced our understanding of the DNA damage response and continues to provide crucial insights that explain how cells deal with genotoxic stress to avoid malignant transformation.More recently, the intriguing phenomenon of cellular heterogeneity reached into the limelight as it became increasingly clear that significant variability exists between individual cells, even of the same genetic background and cell type. Single cells matter, for instance during cellular transformation or tumor relapse, and cellular variability thus impacts disease development and therapeutic outcome. Its determinants are surprisingly unexplored, however, and have not been studied in context of genome integrity maintenance.The main objective of this project is to systematically assess cellular heterogeneity in genome integrity maintenance and characterize its causes and consequences. Quantitative automated high-content imaging of large cell cohorts will be used to identify hitherto unknown determinants of variability in the cellular responses to genotoxic stress and dissect at the single cell level the variability in (1) the chromatin response to DNA double-strand breaks, (2) the cellular response to replication stress, and (3) the cellular capacity to trigger phase transitions, a newly emerging mechanism of dynamic compartmentalization, at sites of genomic lesions. This project will bridge two thus far independently developed research fields (genome stability and cellular
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Experimental Nuclear Magneto-Optic Spectroscopy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This project aims at building a world-unique instrument for measuring novel nuclear magneto-optic spectroscopy (NMOS) phenomena. In NMOS, the differential optical response to polarized nuclear spins is probed. The project aims at observing effects both in the dispersive spectral range, such as Nuclear Spin-induced Cotton-Mouton effect in strong magnetic field (NSCM-B) and Nuclear Quadrupole-induced Cotton-Mouton effect (NQCM), as well as phenomena in the absorptive range such as Nuclear Spin-induced Circular Dichroism (NSCD). The possibility to measure the nuclear magneto-optic effects both in and out of optical resonance, in both Faraday and Voigt geometries and by using either thermal nuclear spin polarization or the more sensitive induced hyperpolarization, offers an advantage over the already established set-ups.The results obtained using the constructed apparatus will serve to prove the existing theoretical predictions of the NMOS phenomena. The ultimate goals are the observation and measurement of the novel NMOS effects as well as the assessment of their ability to resolve chemically different nuclear sites via nucleus-specific response. The proposed techniques offer advantages such as the ability to focus on a particular functional group and to gain local high-resolution information, the use of optical detection and thus, increased sensitivity and resolution over the (in principle) similar Nuclear Magnetic Resonance (NMR). Additionally, NMOS will provide access to new physical observables offering different kinds of localized information than conventional NMR.These achievements will in the future have a potential for opening a wide array of applications of the NMOS effects as high-resolution analytical spectroscopic techniques in molecular and materials research,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'TEXtiles in Etruscan DANCE (8th-5th centuries BC)', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

TEXDANCE will explore Etruscan dance through textiles from 8th to 5th centuries BC. It will use the visual sources to analyse Etruscan society and its élite’s ritual practices in a multidisciplinary approach. This study will make us understand the movements of dance, their ritual functions, their diversity, their performativity and the social relations which intertwine. This is important to understand as textiles in Etruscan dance in particular reflect a different community organisation from the Mediterranean and contribute to question our contemporary European community organisations. Also, for the first time, the two-way transfer of knowledge between dance studies and costume studies will be connected via an innovative approach. The project combines three types of sources: primarily the iconographic representations as they constitute the most important documentation for Etruria, literary sources and archaeological evidence. TEXDANCE has seven objectives: 1. the types of dress and textiles used in dance; 2. dress motion; 3. the acoustics of textiles; 4. Etruscan fashion and dress identity; 5. Etruscan community organisation; 6. ritual textiles making; and, 7. the visuality of textiles. The comparative and interdisciplinary approach includes the history of dance, rituals and religion, performance studies, ethnoarchaeology, archaeoacoustics, sensory studies, motor praxeology, and visual studies. The application of new digital technologies is a crucial aspect with the opportunity to 3D model how cloths move in dance. Digital humanities will also play a fundamental role in the presentation and diffusion of the results that will be made available thanks to a fully open-access philosophy to the scientific community and the general public. Conceived as such, the project is fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Electrogenetics – Shaping Electrogenetic Interfaces for Closed-Loop Voltage-Controlled Gene Expression' (ElectroGene), addressing dissemination and exploitation.

assistant: **Impact**

Man and man-made electronic systems share the same ecosystem, and yet work radically differently. Human metabolism uses ion gradients across insulated membranes to simultaneously process slow analog chemical reactions and communicate information in multicellular systems via soluble/volatile molecular signals. By contrast, electronic systems use multicore central processing units to control the flow of electrons through insulated metal wires with gigahertz frequency and communicate information across networks via wired/wireless connections. With the advent of the internet of things, networks of interconnected electronic devices will reach the processing complexity of living systems, yet they remain largely incompatible with biological systems. Wearable electronics can profile physical parameters such as steps and heartbeat, and Google’s proposal to develop glucose-monitoring contact lenses has triggered a wave of interest in harnessing the full potential of bioelectronics for medical applications. Yet this vision remains limited to diagnostics. Capitalizing on our mind-controlled and smartphone-adjustable optogenetic drug-dosing devices, ElectroGene will establish the foundations of electrogenetics, the science of creating electro-genetic interfaces that enable direct two-way communication between electronic devices and living cells. ElectroGene consists of three pillars, (i) voltage-triggered gene expression, (ii) genetically programmed electronics and (iii) wireless-powered implants providing closed-loop bioelectronic control, which allow real-time monitoring of metabolic conditions (diagnosis), enable remote-controlled production and dosing of protein therapeutics by implanted designer cells (treatment), and manage closed-loop control between cells and electronics, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Enhancing the goverment regulatory energy measures impact and diffusion speed appraisal method (E-GRIDS)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The main objective of this project is to enhance, apply and disseminate the methodology and the simulation tools developed and tested within GRIDS: a RTD project currently being completed in the 5th Framework Programme. To achieve this, a series of well focused activities are been planned, among which:widening the present field of analysis of GRIDS by adding more countries to its database,including the major EU countries as well as the major Accession Eastern countries,organisation of two workshops addressed to the GRIDS direct users, design of and ad hoc Internet tool, investigation of issues still open in the GRIDS methodological approach, creation of a permanent advisory group to support the users to use and implement the tool also after the end of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Defining an integrated model of the neural processing of speech in light of its multiscale dynamics' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

This interdisciplinary project will define an integrated model of speech processing by recording, modelling and manipulating neural oscillatory dynamics during perception of speech defined as a multiscale temporal signal. Dominant models of speech perception describe its underlying neural mechanisms at a static neuroanatomical level, neglecting the cognitive algorithmic and neural dynamic levels of description. These latter can only be investigated by considering the temporal dimension of speech, which is structured according to a hierarchy of linguistic timescales (phoneme, syllable, word, phrase). Recent advances in behavioural paradigms, computational modelling, and neuroimaging data analysis make it now possible to investigate the cognitive algorithms and neural dynamics subtending the processing of speech. To define an integrated model of speech perception, this project seeks to: 1. record neural activity in humans with magnetoencephalography and intracranial recordings during perception of continuous speech; 2. quantify linguistic information at each timescale of speech with a computational model; and 3. estimate their respective and shared neural correlates with multivariate and directed connectivity analyses. Feasibility is ensured by an in-house access to neuroimaging and intracranial recordings as exemplified in the data on Figure 1 of this proposal. This project will critically test whether neural oscillations play a fundamental role in the computational processes of perception and cognition. It will define the mapping between speech and neural timescales and reveal how information is transferred and combined along the linguistic computational processing hierarchy. It will overall specify -in terms of the nature of the information processed and of the dynamic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Green Awareness in Action'.

assistant: **Innovation**

The GAIA project focuses on the educational community; faculty, staff, students and parents at all levels of education: primary/secondary/high schools and universities. Targeting Energy Efficiency in the context of the educational community is clearly very important due to a number of reasons since raising awareness among young people and changing their behaviour and habits concerning energy usage is key to achieving sustained energy reductions and it will also indirectly affect their immediate family environment, while achieving energy reduction in the school buildings. GAIA will create an innovative ICT ecosystem (including web-based, mobile, social and sensing elements) tailored specifically for school environments, taking into account both the users (faculty, staff, students, parents) and buildings (schools, universities, homes) that will motivate and support citizens' behavioural change to achieve greater energy efficiency. GAIA will include also a set of pilots in different countries. GAIA will directly educate over 6.900 users, influence and attempt to transform their behaviour through a series of trials conducted in the educational environment and in homes. We expect a larger number of people to be informed about the activities of GAIA and be positively affected towards an energy-efficient behaviour transformation.


**Keywords:** educational community, behavior change, energy efficient services