RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'genetic control of craniofacial development by hox cofactors Pbx1 and Pbx2' (CRANIOFACIALGENETICS) under Sixth Framework.

assistant: **Objectives**

One third of all human congenital malformations affects craniofacial development and represents a serious concern for society. Within the developing primordia, unique spatio temporal patterns of gene expression correlate with cellular and tissue fates, id entities and behaviours and therefore, morphogenesis.The goal of this proposal is to finely dissect the genetic control of craniofacial development with particular focus on CNC (cranial neural crest cell) cell specification and craniofacial morphogenesis b y Hox homeodomain proteins and their cofactors Pbx1 and Pbx2, through the following specific aims:1) Genetically dissect the early roles of Pbx1 in craniofacial patterning and morphogenesis.To achieve this goal, I will generate knockout mice where Pbx1 is inactivated in a tissue-specific manner in neural crest and in discrete head structures, by utilizing the Pbx1 conditional knockout mouse recently generated in the Selleri laboratory and available Cre mice.2) Identify in vivo genetic interaction of Pbx1 wi th specific Hox genes known to pattern craniofacial structures, such as Hoxa2.In order to uncover possible synergistic interactions of Pbx1 and Hoxa2, responsible for BA2 craniofacial patterning, I will cross Pbx1 and Hoxa2 mutant mice. By doing so, I will attempt to genetically dissect Hox-dependent as well as independent Pbx1 functions that control the BA2 programs. The Hoxa2 mice are made available for these studies by Dr. Rijli (Strasbourg- France).3) Identify genetic interactions and/or overlapping fun ctions of Pbx1 with related family member Pbx2 in craniofacial development.In order to test the possible genetic interactions and overlapping functions between Pbx1 and Pbx2 in craniofacial development, I will analyze CNC derived craniofacial structures in Pbx1
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Randomness and Quantum Entanglement' (RAQUEL).

assistant: **Innovation**

Randomness has established itself as a vital building block of information processing and represents an integral ingredient for practically any aspect in the field of information processing and technology. The principal objective of this project will be to establish and evaluate the role played by randomness in quantum information processing. We propose to address the main difficulties that arise through the use of randomness, in particular, 1) the use of randomness as a theoretical tool to prove existence and properties of information processing applications; 2) the design of novel quantum information processing applications that exploit randomness; 3) the design and analysis of  applications that work with real-world (that is, non-uniform) randomness; 4) the construction of design techniques that produce high-quality randomness, both from a computational and adversarial  perspective; and, finally, 5) the use of randomness to analyze and improve the physical processes necessary for the design quantum communication and computation devices.<br/>The consortium (composed of 8 research teams) aims to unite the forces of EU expertise in computer science, physics and mathematics to undertake a comprehensive study of randomness and quantum information within their research portfolio. Many of the targeted tasks combine the knowledge of partners. Hence, strong research interactions will be necessary to successfully achieve the objectives of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Hi-NEAT (Hierarchical Nanoengineered Assemblies of Titania) sensor' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The proposed research seeks to advance the state of the art in skin cancer diagnostics by developing an electrochemical sensor for tumour markers (or biomarkers) utilizing hierarchical nanoengineered assemblies of titania (Hi-NEAT) nanoparticles. Melanoma is the most aggressive and deadliest form of skin cancer that can spread quickly to other body areas, so its early identification and treatment are vital. The existing histological and immunological cancer detection techniques are intricate, expensive, and often lack sensitivity and specificity. Therefore, in this project, we intend to introduce a subtle, rapid, accurate, facile, and low-cost Hi-NEAT-based electrochemical sensor to detect the biomarker tyrosinase, a crucial enzyme involved in melanin overproduction and development of skin melanoma. The following two research goals have been set forth to achieve this: 1) Creation of Hi-NEAT nanoparticles with enhanced electrocatalytic activity towards tyrosinase via tuning their physicochemical/surface properties and 2) Employing large-scale facilities (synchrotron/neutron sources) to investigate the interfacial properties of the titania-tyrosinase interaction. Thus, the current project represents a groundbreaking approach to push the frontiers of skin cancer diagnosis through the innovative use of titania nanoparticles and large-scale facilities for developing an effective point-of-care electrochemical sensor. Success in this research promises heightened precision and sensitivity in melanoma detection, potentially leading to timely diagnoses and improved patient outcomes. Ultimately, we aspire to make a significant contribution to health care by lessening the severity of melanoma, reducing overall care expenses, and increasing the lifespan of cancer survivors in line w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Protection from malaria in the Fulani ethnic group of West Africa involves reduced levels of A-to-I RNA editing by ADAR1'.

assistant: **Concept**

I will investigate what mediates an effective human immune response to infection with Plasmodium falciparum malaria.I will approach this through studying the Fulani ethnic group of West Africa, who are relatively resistant to malaria infection. The basis of the Fulani protection from malaria has never been established. However, we have performed a pilot study which suggests that reduced levels of adenosine-to-inosine (A-to-I) editing of RNA by ADAR1 following P. falciparum infection can drive a more effective innate immune response in the Fulani. We have an established collaboration with the Malaria Research and Training Centre at University of Sciences Technique and Technology in Mali, who have strong ties to the Fulani community.  At Stockholm University, I have had the opportunity to develop a strong background in immunology research techniques, specifically utilizing in vitro models of malaria infection in human monocytes, in the research group of Eva Sverremark-Ekström. As the role of RNA modifications is an emerging field, I plan to move to CEITEC, Czech Republic, to work with Mary O’Connell, who has pioneered the role of A-to-I RNA modification in the innate immune response to RNA. Specifically, we will test the hypothesis that reduced rates of A-to-I editing of RNA in the Fulani following infection enables them to mount a more effective innate immune response to P. falciparum malaria, and contributes to their relative protection from the disease. Further, targeting of ADAR1 and/or reduction in levels of A-to-I RNA levels may present a novel strategy to boost effective immune response to malaria.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Role of YAP/TAZ on Circulating Tumour Cells' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Metastasis is the leading cause of all cancer-related deaths. Circulating Tumour Cells (CTCs) are cancer cells that shed off the primary tumour, enter into blood vessels and through the blood circulation are transferred to distant organs, whereby they establish new metastatic lesions. CTCs are detected as single cells and/or clusters of cells with clusters being more metastasis-prone than single CTCs. CTC clusters have different sizes varying from 2- to 50-cells. However, it still remains unknown if the different size of CTCs has an impact on their metastatic potential and what factors regulate their size. To elucidate the molecular dynamics of clustered CTC formation, we performed RNA-seq analysis in cells from primary tumours and CTCs and identified the YAP/TAZ gene signature to be upregulated in CTCs. YAP/TAZ is an interesting molecular node, as its function depends on its subcellular localisation. Junctional localised YAP/TAZ inhibits cancer cell dissemination by supporting the maintenance of cell-cell adhesions, while nuclear YAP/TAZ induces a genetic program that promotes cancer progression. We hypothesised that YAP/TAZ could play a critical role on CTC biology, regulating the size and metastatic potential of CTCs. Thus, the aim of this fellowship is to determine the impact of the size of clustered CTCs on establishing metastatic lesions and provide mechanistic insight on the role of YAP/TAZ. More specifically, I will determine: 1) the localisation of YAP/TAZ in CTCs from mouse models and patients with breast cancer, 2) if YAP/TAZ affects the size of clustered CTCs in breast cancer mouse models, 3) if YAP/TAZ localisation affects the metastatic potential of CTC clusters of variable sizes and 4) signals regulating the nucleocytoplasmic shuttling of YAP/TAZ in CTCs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'New generation of Intelligent Efficient District Cooling systems' (INDIGO) targeting Horizon 2020.

assistant: **Abstract**

In Europe, different prognosis show an increase in cooling demand of almost 60% in 2030 with respect to nowadays. District cooling (DC) can play a part in satisfying this demand in a sustainable way (since can offer 5 to 10 times higher efficiency solutions than on‐site stand‐alone distributed systems). Even if DC captures only minor portion of the prospective market, this will translate into a dramatic increase in the size of the global DC sector.INDIGO aims to develop a more efficient, intelligent and cheaper generation of DC systems by improving system planning, control and management, anticipating the aforementioned scenario. This target will be achieved through the following specific objectives:• Contribute to the wider use of DC systems and motivate the competiveness of European DC market by the development of two open-source tools:o A planning tool for DC systems with the aim of supporting their optimal designo A library with thermo-fluid dynamic models of DC System components which will provide the designers detailed information about their physical behaviour• Primary energy reduction over 45% addressed by a ground breaking DC system management strategy focused mainly on energy efficiency maximization but also on energy cost minimization. Its main characteristics is the predictive management but it also will address other challenges such as:o Integration of Renewable Energy Sourceso Dealing with different types of cooling sources o Suitable coupling between generation, storage and demandAll this, with the help of intelligent and innovative component controllers (Predictive Controllers) to be developed at all DC system levels. Some of them include embedded self-learning algorithms, allowing components to respond appropriately to the set-points established.Develop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Optimisation of water use by plants in the mediterranean'.

assistant: **Innovation**

Increasing the efficiency of water use within agricultural systems is critical to ensure stability in agricultural production and food security. This measure aims to establish dialogue and communication between European and Mediterranean scientists, policy makers and other stakeholders concerned with the optimisation of water use in Mediterranean Agricultural systems. Whilst many scientific projects are ongoing in various disciplines working on aspects of water use in plants, in many Eastern and Southern Mediterranean countries water is already at the scarcity level. The holistic approach in this measure aims, to bridge the gap between research scientists working in molecular, genetic and physiological, environmental research and end users. The need for this communication is ongoing and will enable scientists and policy makers and others to make decisions on future research priorities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transgressive Inheritance in plant Breeding and Evolution' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

New varieties of plant and animal are produced by hybridisation of closely related varieties or species. This process generates ""transgressive"" traits that are outside the parental range. Transgressive phenotypes  in hybrids may involve complementation of genetic differences between the two parents, heterozygous advantage, genetic rearrangements and, from our recent work, epigenetic effects associated with RNA silencing.TRIBE will investigate these effects using tomato for which there is a recently published full genome sequences and for which there are well characterised genetic resources based on hybrids between cultivated tomato and its wild relatives. We propose to map the genome and epigenome of F2-F4 generation hybrids between S. lycopersicum and its wild relative S. pennelli and, in parallel, to find out the level of expression of all genes including those producing small silencing RNAs. These data will provide the first systematic analysis of genomes, their expression and epigenetic modifications in the four post hybridisation generations.TRIBE will also explore details of epigenetic mechanisms associated with transgressive traits with a view to their enhancement or suppression to facilitate conventional plant breeding involving wide crosses between crops and their wild relatives. It will also explore the possibility that there is a legacy of epigenetic marks in tomato that have been induced by ancestral hybridisation events.The final outcome of TRIBE will be a test of the hypothesis that hybridisation is important in evolution because it allows not only the formation of new combinations of genes: it is also a process that induces new heritable variation via epigenetic and RNA silencing based mechanisms. It will generate information that will be central to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The breakthrough laser machining intelligence as saver of jobs and competitiveness for Europe's manufacturing business' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

EUR 9.01 trillion – this is the shockingly high amount of added value in manufacturing, which drained off from Europe to other world regions (particularly to regions with low production factor costs like Asia) in the last years. The reason for this can be mainly seen in cost differences of production factors. To retrieve added value to Europe, particularly manufacturing and machining processes have to be improved to greater efficiency. Driven by the vision of Smart Factories of the Future and Industry 4.0, the European Commission therefore starts a lot of initiatives, like the Digital Single Market in 2016. The EC expects that digitisation of products and services can add more than EUR 110 billion of annual revenue in Europe in the next five years. A technology predestined for making machining more efficient and for implementing Industry 4.0 in manufacturing is laser technology (as processing is contactless and therefore very flexible), especially the next level of laser machining based on ultrashort laser pulses resulting in high precision never existed before. Up to now, existing laser machining systems are fixed to only one incorporated laser and therefore limited in parameters and application. This results in the need of having many different laser systems for different applications and in long retooling and adjustment times. For the broad introduction of advanced laser machining in Europe’s manufacturing industry, neoLASE and GFH will during this project integrate the prototype of unique laser amplifier technology in a modular, self-adjusting and self-intelligent laser machining system to reach the next level of manufacturing. This system incorporates several seed lasers and optics, all combinable by the amplifier technology, and therefore has the functionalities o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'More-than-Human Histories of Rural Landscapes in the Andes, 19th-20th century'.

assistant: **Objectives**

HI-LANDeS develops a conceptually innovative and empirically grounded historicising approach to the transformation and governance of rural landscapes. In the face of planetary-wide anthropogenic change, new knowledge and methods are required to better grasp how human and nonhuman lives co-produce socio-environmental transformations through “more-than-human” histories. Strategic sites for carbon storage, water sources, and biodiversity, as well as home to resilient indigenous communities, Andean wetlands offer a unique case-study to examine “more-than-human” landscape histories, and how these can inform contemporary socio-environmental challenges. The main objective of HI-LANDeS is to construct and apply an analytical framework that integrates a historicising, systemic, and more-than-human perspective on rural landscapes to investigate the role of communal practices and knowledge production around water and land in the transformation and governance of rural landscapes. HI-LANDeS departs from two case studies in indigenous communities of the Bolivian-Chilean highlands, based on archival research, fieldwork, and community workshops, analysed within a global framework and a transdisciplinary collaboration. HI-LANDeS will produce new empirical knowledge, critical theoretical insights, and innovative co-creational methods that can contribute to more inclusive conservation and rural development policies, in the Andes, Europe but also more globally. This global fellowship facilitates a three-way transfer of knowledge between expertise in rural history, world-ecology, and rural development at UGent (Belgium), a strong tradition in Andean historical anthropology at UTA (Chile), and the fellow’s trajectory in environmental humanities. Through an intersectoral secondment at NGO Agu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Clear, scalable and scientific framework to measure terrestrial biodiversity' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

3Bee applies technology to MEASURE and REGENERATE ecosystem biodiversity, using bees as sentinels. We collect data through 3 assets:-) HIVE-TECH  IoT sensor integrated in honey beehives to measure the health of a colony.-) SPECTRUM  sensor for wildlife monitoring. Thanks to noises sampled and analysed throughout the year, we monitor pollinators, avifauna and insects in real time.-) FLORA - Satellite data collection with the support of European Space Agency for agronomic analysis (flora density, flowering intensity).Then, we quantify a Biodiversity Index through a scientific methodology and select biodiversity regeneration projects proposed by the 4.000 beekeepers and growers of our network.Biodiversity enhancement is measured through data on nectar potential, honey production, insects diversity and frequency, and our pollination abundance index. This enhancement is certified by means of a disciplinary protocol that follows ISO standards (Element-E protocol) and Biodiversity Credits are generated for establishing the benefits associated with regenerative techniques. Thanks to our technology and AI algorithms, our methodology is scalable: we can exploit data of an area where our in-the-field sensors are installed to assess biodiversity in a much larger territory.Our first customers are large corporations. They have 4 WHY TO BUY:-) ESG reporting improvement. -) Improve transparency of the value chain. -) Improved brand positioning.-) Improved E-NPS (Employee Net Promoter Score).By promoting biodiversity offset projects and generating certified Biodiversity Credits thanks to 3Bee, all these needs will be met.


**Keywords:** Biodiversity, ecosystems restoration, pollinators, AI, IoT, remote sensing