RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The FUture of FUlly integrated human exposure assessment of chemicals: Ensuring the long-term viability and technology transfer of the EU-FUNded 2-FUN tools as standardised solution' to be submitted under Seventh Framework.

assistant: **Abstract**

The assessment of risks to human health from chemicals is of major concern for policy and industry and ultimately benefits all citizens. In this process, exposure assessment is generally considered to be the weakest point, as currently available tools show major flaws:(a) lack of integrated approach for assessment of combined stressors (i.e. a number of potential pollutants);(b) widespread use of ‘worst-case’ scenarios leading to over-conservative results;(c) lack of uncertainty/sensitivity tools that allow identifying the important exposure drivers.To overcome these drawbacks, the FP6 project 2-FUN produced prototype software containing a library of models for exposure assessment, coupling environmental multimedia and pharmacokinetic models. The objective of the 4FUN project is to further improve and standardise the 2-FUN tool and guarantee its long term technical and economic viability.Stakeholder requirements will be identified and an analysis of the strengths, weaknesses, opportunities and threats (SWOT) of existing exposure assessment tools (including 2-FUN) will be conducted. The 2-FUN tool will be subject to a rigorous standardisation which includes verification, benchmarking, documentation and demonstration. To demonstrate the reliability of modelling estimations and the feasibility of building complex realistic scenarios, case studies based on actual datasets will be performed. Improved and standardised 2-FUN software will be delivered, together with supporting documentation and training courses. Finally, based on detailed market research a sustainable business model will be developed.Improved exposure assessment due to the project will(a) reinforce competitiveness by avoiding overregulation;(b) prevent excessive adverse human health effects due to underregulat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Leading edge Semiconductor, Integration, and Control System Technologies for highly compact and smart eDrive Components towards more sustainable Power Electronics 5.0'.

assistant: **Objectives**

HiPower 5.0 is driven by the challenges and ambitions addressed in the Green Deal and in the Chips Act, to develop new power electronics solutions to ensure Green Deal targets and to foster a resilient and leading edge all-European Value Chain, for tomorrow’s mobility solutions. Therefore, HiPower 5.0 aims for developing highly integrated eDrive components for the automotive and maritime domain using leading edge wide bandgap semiconductors and power electronics integration technologies. This includes the development of new GaN wafer materials with superior performance, first time 850 V monolithically integrated bidirectional GaN switches, enabling new topologies and unprecedented efficiency levels of 99%, as well as 1200 V GaN switches fitting the needs of 800 V battery electric vehicles. When developing these solutions, a resource-efficient and reliable design is considered to minimize CO2 footprint and extent the lifetime of power electronics components. Firstly, multi-physics simulation with its ability to model the complex interactions between electrical, thermal, electro-magnetic, and mechanical phenomena will be used. By simulating these interactions, the system design can be optimized while performances can be predicted under various operating conditions, reducing the need for prototyping, and cutting both time and costs of development. Secondly, new ageing models and prognostics concepts will be developed to finally enable an according evaluation of the set targets of the single applications. Supported by innovations in power electronics control and cooling the lifetime and reliability will be further enhanced.To achieve these targets, the HiPower 5.0 consortium is composed along the whole value chain, starting from the GaN wafer and chips development, up to au
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Scanning probe research on nanoscale magnetism of advanced materials for high resolution recording' to be submitted under Fifth Framework.

assistant: **Abstract**

The aim of this research project is the improvement of magnetic materials for state-of-the-art read heads for magnetic data storage technology and the attendant necessity for the development of magnetic imaging techniques. This will on one hand lead to a further development of magnetic storage technology and on the other hand enhance the competitiveness of European manufacturers in the field of scanning probe microscopy. To reach this goal, test samples have to be produced and used to optimize Magneto-Optic near field scanning microscopy, magnetic force microscopy and spin-polarized scanning tunneling microscopy in order to reach magnetic image resolutions in the 10nm regime.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Towards Highly-Efficient Two-Photon Absorbing Sensitizers within a Confined Chromophore Space: From Computer-Aided Design to New Concepts and Applications' (TWOSENS) under Horizon 2020.

assistant: **Objectives**

Materials exhibiting large two-photon absorption (TPA) are in great demand to meet the needs of emerging laser technologies and applications in medicine and biomedical engineering (bioimaging, photodynamic therapy, microfabrication). Most design strategies to enhance TPA activity rely on construction of extremely large pi-conjugated molecules, which are not appreciated in practice due to difficulties connected with their synthesis or low cell permeability. The fellow recently demonstrated that significant TPA enhancement can be achieved by small perturbations in the heteroaromatic unit, but these effects are often hardly predictable or chemically counter-intuitive.The objective of this action is to provide material chemists with general guidelines for construction of heteroaromatic-based sensitizers and their metal complexes displaying very high TPA within a confined chromophore space. This will allow to avoid trial-and-error experimentation done so far. A systematic computational study of TPA cross-sections using state-of-the-art quantum-chemical methods for a large set of different heteroarene platforms and substitution patterns will furnish essential structure-property relationships and their understanding based on extensive analysis will bring new knowledge for boosting the TPA efficiency. The most promising candidates will be synthesized and their efficiency will be demonstrated in real applications.The HI and International Laser Center offer excellent multidisciplinary research environment and enable the fellow an access to their unique expertise in highly accurate electronic structure methods and instrumentation. In return, the fellow will bring his unique combined experience in computer simulations and synthesis of nonlinear optical materials as well as new coll
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Decoding Epileptogenic Glioma Networks Using Forebrain Assembloids' under Horizon Europe.

assistant: **Concept**

Pediatric-type diffuse high-grade gliomas are the primary cause of cancer-related mortality in children and adolescents. The most common and aggressive forms harbor mutually exclusive mutations in histone 3 (H3), involving distinct brain regions and developmental origins. In contrast to other gliomas, GABAergic interneuron progenitors are implicated as the cells of origin for H3G34-mutant diffuse hemispheric gliomas (DHGs), which almost exclusively affect the cerebral hemispheres.Seizures are a common comorbidity in patients with cortical gliomas, with evidence suggesting that gliomas alter synaptic structures to induce hyperexcitability. Neuronal activity, in turn, accelerates glioma progression through paracrine signaling and neuron-to-glioma synapses. Despite their cortical involvement, high seizure incidence, and poor prognosis, neuron-glioma interactions in DHGs remain understudied.Human cerebral organoids, pioneered by the Knoblich Lab, recapitulate early brain architecture and circuit assembly via excitatory neurogenesis (dorsal forebrain) and interneuron development (ventral forebrain). Ultimately leading to functional network activity with complex oscillatory dynamics, organoids provide the ideal platform to study brain tumors in the context of network pathologies.In this project, I will develop patient-derived models of seizure-associated DHGs in brain region specific cerebral organoids to examine neuron-glioma synapses. Using barcoded viral tracing and genetic perturbation screening, I will identify synaptic interaction partners and tumor-specific anti-connectivity targets. Electrophysiological recordings will assess the effects of anti-epileptogenic and anti-tumorigenic perturbations. This work will provide critical insights into neuron-glioma communication
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Characterization of the somatostatin receptor sstr2 tyrosine phosphatase ptp1c complex. Its role in the somatostatin induced negative growth signal transduction' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

SOMATOSTATIN (SS) ANALOGS ANTAGONIZE THE MITOGENIC EFFECT OF GROWTH FACTORS AND STIMULATE A MEMBRANE TYROSINE PHOSPHATASE (PTP), POSSIBLY IMPLICATED IN CELL PROLIFERATION. PTP1C HAS TWO SH2 DOMAINS THAT INTERACT WITH GROWTH FACTOR RECEPTORS, AND IS ABLE TO DEPHOSPHORYLATE THESE RECEPTORS. THE ACTIVATION OF THE SS RECEPTOR SSTR2 LEADS TO STIMULATION OF A PTP ACTIVITY AND INHIBITION OF CELL PROLIFERATION. THERE IS A SSTR2-PTP1C COMPLEX CAPABLE OF BINDING SS AND HAVING PTP ACTIVITY. OUR OBJECTIVE IS TO CHARACTERIZE THIS COMPLEX AND DEMONSTRATE ITS ROLE IN THE ANTIPROLIFERATIVE SIGNAL. WE WILL INVESTIGATE THE RECEPTOR SEQUENCES INVOLVED IN THE FORMATION OF THE COMPLEX USING MOLECULES MODIFIED IN THE INTRACELLULAR REGIONS INVOLVED IN THE SIGNAL TRANSDUCTION MECHANISM. THUS, CHIMERIC SSTR2SSTR3 MOLECULES (NOT COUPLED TO PTP1C) AND N- OR C-TERMINALLY TRUNCATED PTP1C MOLECULES WILL BE CONSTRUCTED. THIS WILL ALLOW US TO DEFINE THE IMPORTANT SEQUENCES IN THE FORMATION OF THE COMPLEX AND THE ROLE OF PTP1C IN THE ANTIPROLIFERATIVE SIGNAL.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Stratospheric cOmposition in a changing CLIMate: drivers and mechanisms' (SOCLIM) under Horizon Europe.

assistant: **Objectives**

Progress towards more useful and accurate weather and climate predictions requires identifying predictability sources, as well as constraining the circulation response to climate change. While the stratosphere plays a key role in these aspects, efforts have largely focused on dynamical aspects, disregarding its chemical composition. Ozone and water vapour largely determine the stratospheric chemical composition, but also protect the biosphere from harmful UV radiation and contribute to the Greenhouse Effect. Despite advances in understanding the effects of Antarctic ozone depletion and recovery, impacts in Arctic and global stratosphere are not understood.This is due to limited understanding of the complex interactions between stratospheric composition and circulation and their poor representation in models. The SOCLIM project will provide new understanding of the role of stratospheric ozone and water vapour as (1) source of predictability on sub-seasonal to seasonal (S2S) time-scales, (2) drivers of atmospheric circulation and (3) radiative effects on global climate by using theory, observations and models. We will develop, for the first time, a chemistry-weather predictionsystem to assess impacts on predictability. Then, we will use two independent chemistry-climate and other IPCC models to quantify impacts on climate change, via the influence of stratospheric composition on the atmospheric circulation response. Lastly, we will determine its contribution to global warming in a range of scenarios from unabated emissions to mitigation via geo-engineering. SOCLIM will provide new process-based understanding of stratospheric composition feedbacks on regional and global climate for a range of timescales never explored before. If successful, it will contribute towards reduc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Covalent Chaotropic Membrane Transport for Biotherapeutic Delivery (CARAMEL)' to be submitted under Horizon Europe.

assistant: **Abstract**

Finding new synthetic compounds that facilitate membrane transport of impermeable bioactive molecules constitutes one of the grand scientific challenges in chemistry, biology, and medicine. Until today, the design principles of artificial transporters have been mainly restricted to membrane-targeting molecules with segregated hydrophilic and hydrophobic domains. We propose a disruptive strategy that uses boron clusters as membrane carriers that abandon the classical amphiphilic topology and exploit the (super)chaotropicity of boron cluster anions. Chaotropicity, historically associated with the salting-in effects of ions on proteins, has only recently been related to the affinity of large cluster ions to hydrophobic surfaces. In comparison to amphiphilic carriers, boron clusters are fully inorganic, highly water-soluble, globular in shape, and induce direct membrane transport despite being anionic in nature. The mere existence of these carriers defies all previous conceptual assumptions and biomimetic design criteria. Here, we introduce a new scenario for chaotropic membrane transport. A new chaotropic strategy will be introduced. A systematic transport screening will be carried out to study the fundamental physicochemical parameters and to generate a cargo-dependent predictive model for covalent chaotropic transport. Functional biomolecular hybrids will be validated to achieve proof-of-principle for the therapeutic potential. This proposal is aimed to fully unfold the potential of the new chaotropic scenario and intended to shake the very foundations of research in membrane transport.


**Keywords:** lipid bilayer, membrane transport, synthetic membrane carriers, peptide chemistry, counterion activation, boron clusters, intermolecular interactions, boron clusters, chao
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Open-Centre Tidal Turbine Industrial Capability' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

OpenHydro holds a unique position in the tidal industry. It has  developed a state-of-the-art Open-Centre Turbine with a proven ability to generate and deliver electricity to the national grid and a patented method to deploy and recover turbines quickly, safely and economically on the seabed. Simplicity is at the core of OpenHydro’s design philosophy: the turbine has only one moving part, minimising the number of interventions for maintenance. Fundamentally, the Open-Centre Turbine system is designed to deliver the lowest cost of energy. Since the installation of OpenHydro’s first turbine in 2006, the technology has been developed and tested extensively, with prototype designs optimised to provide higher outputs and improved economics. Validation of the full-scale, 2.0MW 16 metre turbine system following the deployment, grid connection and operation of a two turbine array at the Paimpol-Bréhat test site in France brings the technology to TRL 7. OpenHydro’s stated objective is to match and beat the Levelised Cost of Energy (LCoE) of offshore wind. The OCTTIC FTI Pilot project, which brings together a consortium of 4 industrial partners led by OpenHydro, will achieve this through advancement of the turbine system design to improve performance, efficiency and reliability. These advancements when combined with a reduction in operational and maintenance requirements, will deliver significant reductions in capital and operational costs to achieve LCoE targets. OCTTIC will establish a robust industrial production platform and the associated supply chain to produce, assemble and deploy the turbines at scale to deliver LCoE targets and lead the development of the tidal energy market. The outputs of this project will be implemented immediately through the deployment of commercial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Legendrian contact homology and generating families' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

A contact structure on an odd dimensional manifold in a maximally non integrable hyperplane field. It is the odd dimensional counterpart of a symplectic structure. Contact and symplectic topology is a recent and very active area that studies intrinsic questions about existence, (non) uniqueness and rigidity of contact and symplectic structures. It is intimately related to many other important disciplines, such as dynamical systems, singularity theory, knot theory, Morse theory, complex analysis, ... Legendrian submanifolds are a distinguished class of submanifolds in a contact manifold, which are tangent to the contact distribution. These manifolds are of a particular interest in contact topology. Important classes of Legendrian submanifolds can be described using generating families, and this description can be used to define Legendrian invariants via Morse theory. Other the other hand, Legendrian contact homology is an invariant for Legendrian submanifolds, based on holomorphic curves. The goal of this research proposal is to study the relationship between these two approaches. More precisely, we plan to show that the generating family homology and the linearized Legendrian contact homology can be defined for the same class of Legendrian submanifolds, and are isomorphic. This correspondence should be established using a parametrized version of symplectic homology, being developed by the Principal Investigator in collaboration with Oancea. Such a result would give an entirely new type of information about holomorphic curves invariants. Moreover, it can be used to obtain more general structural results on linearized Legendrian contact homology, to extend recent results on existence of Reeb chords, and to gain a much better understanding of the geography of Legendrian su
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The virtual sound platform of the future' (Treble).

assistant: **Innovation**

Today, it is challenging to simulate how products – cars, audio equipment, buildings, wind turbines, hearing aids, etc – will sound. The same limitation applies to simulating and rendering sound for virtual spaces, i.e., virtual reality, metaverse, video games and augmented reality. We have developed a disruptive sound simulation technology based on an entirely new paradigm (“wave-based” methods versus traditional “ray tracing” methods). This technology opens a vast array of new opportunities in engineering design and metaverse applications. We offer a ground-breaking cloud-based sound simulation software platform with a cutting-edge proprietary simulation technology at its core with two main capabilities:• Sound simulation: Predict, design and optimise how products & buildings will sound. • Sound rendering: Generate authentic sound in a virtual domain.The technology is 100-1000x faster than current technologies, resulting in a complete paradigm shift in sound simulation.


**Keywords:** signal processing,spatial audio,computational mathematics,high-performance computing,architectural acoustics,dev-ops,cloud computing,sound simulation technology,machine learning,gaming audio,audio reproduction,virtual acoustics,sound rendering,,wave-based methods,engineering acoustics,BIM solutions