RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Quantitative understanding of target recognition on DNA based on directional zipping processes' (ZIPgeting), addressing dissemination and exploitation.

assistant: **Impact**

In the recent years a number of protein systems have been identified that recognize long (tens of base pairs) DNA sequences and allow flexible programmability of their target specificity. This promoted an enormous range of applications in genome engineering and synthetic biology. This project aims to decipher the mechanisms by which these proteins recognize their DNA targets in order to develop quantitative models/predictors for target recognition and to avoid off-target effects.To obtain detailed insight into the targeting mechanisms of different programmable systems in a “bottom-up manner”, cutting-edge single-molecule experiments, such as mechanical DNA twisting combined with single-molecule fluorescence detection will be employed. This will provide a fully quantitative characterization of the targeting process and insight into the mechanisms of allosteric regulation coupled to targeting. The quantitative data will allow to develop physics-based models of the target recognition process. In particular, we will focus on recognition through non-equilibrium, directional zipping along the target sequence – as recently revealed for CRISPR-Cas enzymes – as a promising unifying mechanism. To obtain precise targeting predictors our first-principle models will be tested and refined using high-throughput measurements on many different targets in parallel. Finally, the predictions will be used in order to understand target selection in live cells using single-molecule imaging.Within the project the following goals are defined: Goal 1:Quantitative understanding of target binding/degradation for CRISPR-Cas systemsGoal 2:Detailed mechanistic insight into the target recognition process by TALEs  Goal 3:Development of highly parallelized measurements on different target sequences dow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Gravitational-wave data mining', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Gravitational-wave astronomy is entering its large-statistics regime. Catalogs with thousands of gravitational-wave events will soon be available, providing a wealth of information on the most compact objects in the Universe  --black holes and neutron stars. These new datasets need new tools to be exploited effectively in order to maximize their scientific impact. GWmining is an ambitious program to explore upcoming gravitational-wave catalogs with data-mining techniques. We will develop a complete framework to analyze gravitational-wave data in light of astrophysical predictions. Going beyond phenomenological models, we will train machine-learning algorithms directly on large banks of population-synthesis simulations and post-Newtonian integrations. The development of these astrophysical predictions requires new modeling strategies to accurately capture all the gravitational-wave observables, notably spins and eccentricities.Combined with a hierarchical Bayesian analysis, our neural network will deliver the most stringent measurements to date on elusive phenomena influencing the lives of massive stars. We will constrain phenomena such as binary common envelope, supernova kicks, stellar winds, tidal interactions, etc.Besides harnessing the catalog in its entirety, our complete framework will put us at the forefront to analyze outliers --golden events with favorable properties of one or more parameters. We will design a complete strategy to exploit the strongest signals to infer exquisite details of the relativistic dynamics of their sources.GWmining is a unique project strategically placed at the intersection of astronomy, data analysis, and relativity.  As the large-statistics revolution of gravitational-wave astronomy unfolds, GWmining will pioneer the application of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Linking social network dynamics and demographic change in wild populations' (NETDEM).

assistant: **Innovation**

Quantifying the interplay of demography and social structure is a key challenge in diverse research fields from ecology to sociology. Social relationships, and the way they are interconnected to form the social network of a population, are closely linked to population dynamics. Changes in population size can change these networks, with implications for important ecological or evolutionary processes, such as cooperation, conflict and infectious disease spread. For example, links between social structure and demography can influence whether a population acts as a reservoir host of diseases with societal impacts, or shape how social animals respond to sudden human-induced environmental change. However, due to the complexity of quantifying the demography and social network structure of wild populations, we still understand little about how interplay between the two arises or when it is important. The objectives of the proposal are to develop a modelling framework that allows the integration of demography and social network structure, and apply it to gain insights into social and disease dynamics in European badgers. Through cross-disciplinary collaboration, I will integrate cutting-edge statistical approaches in the modelling of social networks and population dynamics, and produce software to make these new tools widely available to other researchers. The host lab, led by Dr Gimenez has world-leading expertise in mathematical ecology, animal demography and conservation. The candidate, Dr Silk, is an expert in applying social network analysis to study behavioural dynamics and infectious disease transmission. This combined skillset will enable the development of innovative statistical tools that can be applied across research disciplines (e.g. ecology, sociology, public healt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Millimetre-Wave Based Mobile Radio Access Network for Fifth Generation Integrated Communications', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The mmMAGIC (Millimetre-Wave Based Mobile Radio Access Network for Fifth Generation Integrated Communications) project will develop and design new concepts for mobile radio access technology (RAT) for mm-wave band deployment. This is envisaged as a key component in the 5G multi-RAT ecosystem and will be used as a foundation for global standardization. The project will thus enable ultrafast mobile broadband services for mobile users, supporting UHD/3D streaming, immersive applications and ultra-responsive cloud services. The consortium brings together major infrastructure vendors (Samsung, Ericsson, Alcatel-Lucent, Huawei, Intel, Nokia), major European operators (Orange, Telefonica), leading research institutes and universities (Fraunhofer HHI Institute, CEA-LETI, IMDEA Networks, Universities Aalto, Bristol, Chalmers and Dresden), measurement equipment vendors (Keysight Technologies, Rohde & Schwarz) and one SME (Qamcom). To complement its strong industry leadership and academic excellence, the project has an Advisory Board drawn from major European telecommunications regulators in Germany, France, Finland, Sweden and the UK. A new radio interface, including novel network management functions and architecture components will be proposed, taking as guidance 5G PPP’s KPI and exploiting the use of novel adaptive and cooperative beam-forming and tracking techniques to address the specific challenges of mm-wave mobile propagation. The project will undertake extensive radio channel measurements in the 6-100 GHz range, and will develop and validate advanced channel models that will be used for rigorous validation and feasibility analysis of the proposed concepts and system, as well as for usage in regulatory and standards fora. The ambition of the project is to pave the way for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Roadmap for Research and Innovation in Health Technology' (ITECH).

assistant: **Concept**

Research and innovation in Health Technologies continuously deliver new products, devices and services. The “idea to market” process is complex due to multiple actors, institutional bodies and operators. The ITECH project aims at defining a strategy plan in Health Technologies to contribute to the Horizon 2020 Common EU Strategic Framework for Research and Innovation. The Support Action will gather EU and national networks or experts, representative of researchers, physicians, companies and health organizations. The key issue is: “What is the best strategy to optimize research & innovation and translate research into successful Health Technology products and services?” ITECH is an opportunity for identifying throughout Europe gaps and barriers currently existing at all stages of the “idea to market” process and to propose a strategy to accelerate and support this process.The objectives are:1: To map existing national and European instruments supporting research & innovation and the “idea-to-market” strategy; identify the similarities and dissimilarities between countries2: To build and validate a model describing the phases of maturation of innovation3: To identify, from this model, gaps and barriers currently existing at all stages4: To propose solutions to overcome the identified gaps and barriers5: To find the best schemes for promoting synergies and collaborations with existing actions6: To road map the areas where European research and industry can take a worldwide leadership role7: To disseminate the outcomes of the project to all actors involved in the process “idea-to-market”.The ultimate goal is therefore to build a perennial network of referents in Healthcare Technologies integrating the experience of 27 European contact nodes and to propose to decision makers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Execution Models for Energy-Efficient Computing Systems'.

assistant: **Concept**

The EXCESS project aims at providing radically new energy execution models forming foundations for energy-efficient computing paradigms that will enable two orders of magnitude improvements in energy efficiency for computing systems. A holistic approach that involves both hardware and software aspects together has the best chances to successfully address the energy efficiency problem and discover innovative solutions. EXCESS proposed models will try to describe and bridge embedded processors models with general purpose ones. EXCESS will take a holistic approach and will introduce novel programming methodologies to drastically simplify the development of energy-aware applications that will be energy-portable in a wide range of computing systems while preserving relevant aspects of performance.The EXCESS project is going to be driven by the following technical components that are going to be developed during EXCESS: Complete software stacks (including programming models, libraries/algorithms and runtimes) for energy- efficient computing. Uniform, generic development methodology and prototype software tools that enable leveraging additional optimisation opportunities for energy-efficient computing by coordinating optimisation knobs at the different levels of the system stack, enabled by appropriate modelling abstractions at each level. Configurable energy-aware simulation systems for future energy-efficient architectures.<br/>The EXCES consortium unites Europe's leading experts in both high-performance computing and embedded computing. The consortium consists of world-class research centres and universities (Chalmers, LIU, UiT), a high performance computing centre (HLRS at USTUTT), and a European embedded multi-core SME (Movidius), and has the required expertise to acco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Flow Visualization Based Pressure' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The ERC-FLOVIST project has focused on advancing Tomographic Particle Image Velocimetry (PIV) towards a versatile technique for the non-intrusive diagnostics of aero-acoustic problems. One of the milestones has been the use of Tomo-PIV to infer the instantaneous three dimensional pressure field from the velocity measurement. The use of this laser-based technique for the detection of pressure fluctuations both around and on the surface of aerodynamic models offers the advantage that surface pressure transducers do not need to be installed, along with connecting cables for power supply and data transfer.The technique has demonstrated high scalability and pressure fluctuations were detected from low-speed up to the supersonic flows. This is an important headway from standard technologies (surface pressure transducers and microphone arrays) favouring a broader utilization of PIV in aero-acoustics, flow-induced vibrations and bio-fluid mechanics. The potential of this innovative approach has been recognized in science. However, the industry lags behind with a more conservative position, partly justified by system complexity and the high skills required to perform experiments. Instead, when correctly implemented this method can lead to important economical benefits with saving of costs for the integration of instrumentation. The targeted industrial areas are: aeronautics (aircraft aerodynamics and propulsion), energy systems (turbo machinery and wind energy). In wind-energy, the study of unsteady loads may lead to designs that reduce fatigue loads and increase system durability. Also, growing interest in noise emissions from wind turbines requires increased capabilities for their aero-acoustic analysis.The proposal intends to move forward these capabilities from research labs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Flexible systems for footwear manufacturing within the supply chain' under Fourth Framework.

assistant: **Concept**

Traditional planning methodologies are becoming increasingly inadequate for Footwear manufacturers. The demands of modern production, eg quick response, team working, sourcing of partially completed goods, multiple manufacturing sites and facilities and the role in the supply chain are not handled by standard MRP systems. In addition these systems are often beyond the capability of the SME to administer given their limited resources. This project proposes the development of a prototype planning and control system which is both flexible enough to meet changing demands, and is powerful enough to perform all of the functions required whilst still retaining ease-of-use for SME's. The benefits of a successful conclusion will apply not only to the Prime proposer and partners, but also to any SME operating in a similar environment. These benefits are likely to include shorter lead times within the Supply Chain; better control of purchasing of materials and components; shorter manufacturing cycle times; better use of manpower and plane and equipment and an overall reduction in operating costs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Studies on jasmonate modulation of distal stem cell activity in Arabidopsis root' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Postembryonic root growth of higher plants is maintained by the root meristem (Dolan et al., 1993, Development, 119: 71-84; Weigel and Jürgens, 2002, Nature, 415: 751-754). Our previous studies have highlighted the importance of MYC2-mediated jasmonate signalling in regulating root meristem size by repressing auxin signalling (Chen et al., 2011, Plant Cell, 23: 3335-3352). At the cellular level, we showed jasmonate is capable in disturbing the cellular patterning of the stem cell niche by promoting cell division in quiescent center (QC) and distal stem cell (DSC) differentiation. Maintenance of stem cell activity is crucial for the persistence of postembryonic root growth and many questions on how roots preserve their stem cell niche remain unanswered. Furthermore, nothing is known on how jasmonate signalling interferes with stem cell activity.In this project, we will take profit from the accessibility of the DSC in the Arabidopsis root and will focus our efforts on jasmonate signalling in regulating DSC activity during postembryonic root growth. By DSC specific expression profiling in combination with a comparative analysis of other root specific transcriptome analyses (Birnbaum et al., 2003, Science, 302: 1956-1960; Brady et al., 2007, Science 318: 801-806), we will be able to identify targeted genes involved in jasmonate-regulated DSC differentiation. Genetics tools, cell biology and biochemical techniques will be used to study the mechanisms underlying jasmonate-regulated DSC maintenance. The project will extend our view on how plants retain growth plasticity and on how plants translate stress cues into growth responses.The aim of the fellowship is to add to my knowledge and skills in order to broaden my career prospects in line with the needs of the future knowledg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European project on the characterisation of transgenic rat models for neurodegenerative and psychiatric diseases: Automated home cage analyses, live imaging and treatment' (RATSTREAM) targeting Sixth Framework.

assistant: **Abstract**

The RATstream' consortium will concentrate on the comprehensive phenotypical characterization of rat models of neurodegenerative diseases such as Huntington's disease (HD), Parkinson's disease (PD) and spinocerebellar ataxia type 17 (SCA17). Ultimately, the project will deliver a procedure for low cost automated drug screening along with a set of data describing the phenotype for each of the models. To achieve this goal, automated home cage systems for behavioural and physiological phenotyping will be developed by two SMEs and validated independently by two academic partners and individual data will be incorporated into an integrated database developed by a third SME. In a joint effort the groups will develop a comprehensive set of behavioural and physiological phenotyping procedures including PET and DTI technologies to systematically detect neuropsychiatric correlates of neuronal dysfunction and disease progression in rat models of HD, PD, and SCA17. The resulting set of biomarkers will lead to a valid set of minimised experiments and markers best suited to provide read-out parameters in pre-clinical studies applying novel substances delaying or preventing neurodegeneration.'