RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Metal-Oxide Polymerization Chemistry:  From Molecular Vanadium Oxide Monomers to Supramolecular Oligomers and Polymers' to be submitted under Horizon 2020.

assistant: **Abstract**

State-of-the-art metal oxide chemistry lacks the ability to predictably design materials and their properties from the atomic level upwards. This ability, however, would provide ultimate control over metal oxide structure and reactivity, leading to designer materials to deliver solutions in areas including information technologies and sustainable energy. In addition, understanding the supramolecular chemistry which governs metal oxide aggregation is expected to provide fundamental insights into spontaneous structure organization and the rise of complexity in prebiotic chemistry. SUPRAVOX proposes bottom-up vanadium oxide polymerization chemistry as a new design paradigm to bridge the gap between molecular building blocks and solid-state metal oxides. This is achieved by developing chemically tuneable molecular vanadium oxide monomers as models for an industrially important metal oxide class. The conception of rational supramolecular aggregation routes will enable the initiation, propagation and termination of vanadium oxide monomer growth into metal oxide oligomers and polymers. SUPRAVOX will explore the chemical evolution of vanadium oxide oligomers in and out of thermodynamic equilibrium to develop reversible aggregation control beyond classical molecular chemistry. This will lead to the first examples of inorganic systems chemistry and enable unique structural design approaches, such as self-sorting, self-recognition and stimuli-response. The technological relevance of the systems will be demonstrated by their electrode surface-deposition. We propose that tuning of polymer structure and size will directly affect their electrochemistry based on quantum confinement effects. In sum, SUPRAVOX will lay the synthetic and mechanistic foundations for metal oxide polymerizati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Phenotypic and lineage diversification of natricine snakes'.

assistant: **Objectives**

The NATRICINE project is a study of the macroevolution of a major group (240 extant species) of snakes. Natricines originated in Asia and dispersed into N America, Africa and Australasia. They are diverse, with repeatedly evolved surface, burrowing and aquatic ecotypes. The overarching project aim is to determine the extent to which lineage and phenotype diversification is impacted by dispersal to new regions (potentially providing ecological opportunity) and by evolutionary transitions between ecotypes. The overarching aim will be tackled via four main research objectives: molecular phylogenetics to determine the interrelationships among >70% of all natricine species; historical biogeography to identify ancestral areas and the location and timing of major dispersal events; phenotypic disparity and diversity analyses to quantify the main axes of natricine variation in time and space; quantitative analyses to test whether different ecotypes and geographical groups have undergone different rates of lineage and phenotype diversification. These four objectives will be tackled in four work packages. The topic is novel and the approach is innovative in combining cutting-edge techniques including amplification of DNA sequences from historical museum specimens, quantifying shape variation using the latest surface and microCT scanning approaches, and model-based analyses of trait and lineage evolutionary rate shifts. The project will be undertaken by an early-career postdoctoral researcher, who has expertise and solid grounding in Asian reptile systematics, ecology and evolution, but who requires training in advanced Next Generation Sequencing, 3D imaging and macroevolutionary quantitative analysis. The fellow will also receive training in public engagement, project management,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Building a common database on scientific research and public decision on TSE in Europe' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The experience of the BSE crisis in Europe reveals the needs of a better exchange of data within the scientific community and between this community, the policy-making area and interests groups. Have we had a tool to exchange these data, the research of tests to detect TSE pathogens could probably have lead to earlier results. But also, such a tool could have helped to identify weak signals that appeared before the crisis developed. The kind of data base which we propose to construct does not yet exist on either a national or an EU-wide basis. Indeed, the primary objective of this project is to construct an integrated relational data base which will include, in a detailed chronological form, information on the emergence of scientific information on BSE and other TSEs, and the responses to those developments in the form of research programmes and projects and in the form of expert and official advice and regulations (SEPD" data base). This data base will be updated during the entire period of the project. It will be accessible on the WEB. The second objective will be to analyse the data on the emergence of scientific evidence and the responses of various EU Member States to that evidence in terms of both regulatory and research policies, with a view to constructing a set of benchmarks by reference to which an early warning system will de designed and constructed. Partners will be based in France (including overall co-ordination and co-ordination of scientometrics and databases), Netherlands (including co-ordination of the design of a monitoring and early warning system), the UK (including co- ordination of decision making analysis) and Portugal (including co-ordination of the analysis of national action systems). Deliverables will include reports on national action syste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Medical end-of-live decisions: attitudes and practices in 6 european countries' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Advances in medical technology and the emphasis in modern society on patient autonomy have, among other factors, increased the scientific and societal debate on the role of medicine at the end of life. In this project, the incidence, characteristics and attitudes concerning end-of-life decision-making will be assessed in 6 European countries in two surveys. The first involves the medical decision-making that preceded a random sample of death cases; the second involves experiences and attitudes of a random sample of general practitioners and other physicians frequently confronted with death. The data will be analysed in the light of differences in the health care systems and in cultural, socio-economic and other characteristics. The results of this project will help physicians, citizens and public health policy makers in Europe in developing rational, evidence-based policies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Longevity assurance genes in tumor suppression' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

DNA damage has been implicated as a causal factor of cancer development and is thought to contribute to aging. The effect of DNA damage both in cancer and aging becomes particularly apparent in patients that are defective in nucleotide excision repair (NER). NER comprises two distinct branches that differ in the initial damage recognition and lead to distinct clinical outcomes. Global genome (GG) NER recognizes damages throughout the genome, whereas transcription-coupled repair (TCR) specifically removes damage during transcription. GG-NER deficiencies lead to the skin cancer susceptibility syndromes xeroderma pigmentosum (XP) whereas TCR deficiencies lead to progeroid conditions Cockayne syndrome (CS), trichothiodystrophy (TTD) and XPF-ERCC1 progeria (XFE). Recently, we have identified specific cellular response programs to persistent transcription-blocking lesions. We showed that persistent transcription-blocking lesions lead to attenuation of IGF-1R and GHR resulting in cellular IGF-1 resistance. IGF-1R and GHR are central regulators of somatic growth and their attenuation leads to extended longevity and stress resistance. IGF-1R has been shown to act as oncogene and pharmaceutical interventions targeting IGF-1R are in advanced clinical trials for cancer treatment. We have found that, in contrast to cells from tumor prone XP mice, primary cells from progeroid CS or XFE mouse models induce a prolonged IGF-1R and GHR attenuation. We proposed that somatotropic attenuation might be the critical determent of the progeroid but tumor free outcome of TCR deficiencies and the tumor prone outcome of GG-NER deficiencies. In this proposal we aim at investigating genetic interactions of skin cancer models of XP and IGF-1R knockout mutants. We thus aim at investigating tumor suppr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'World Input-Output Database: Construction and Applications' (WIOD).

assistant: **Concept**

How has the increase in Chinese exports of textile products affected the employment of low skilled workers in German retail trade? What would be the effects of a change in the European Union’s agricultural policy on global CO2 emissions? Economic and environmental policies are designed at a detailed level of industries and products, while production is characterized by an interdependent structure. Due to globalization, these interdependencies cross borders and the inclusion of trade is more than ever essential. Analyzing policy issues therefore requires an all-encompassing database. Its construction is at the heart of this project and the following three aspects are crucial.  • Input-output (IO) tables provide a description of the interdependent production structure. Taking the reach of internationalization into full consideration requires a worldwide set of national IO tables (covering at least 80% of world GDP) that are fully linked through bilateral trade data.  • Taking the dynamics of internationalization into account requires a time series (1995-2006) of such linked IO tables, in current and constant international prices.  • Taking the effects of internationalization into consideration requires that other relevant information is appended. These so-called satellite accounts include labor data for different skill types, investment flows, and environmental and resources data.  The first part of the project constructs such a unique database. The second part of the project applies the database to analyze the international interaction of socio-economic and environmental objectives from a policy perspective. These are applications that use the database by directly employing IO and econometric techniques, and applications that use large-scale models that employ the databa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Functionalisation of ultra-bright all organic nanoparticles for super resolution imaging in intact brain preparations' (NanoFUNC).

assistant: **Concept**

Nanotechnologies have the potential to revolutionise our understanding of devastating diseases such as cancer or neuropathologies. By combining light-emitting nanoparticles (NPs) and super-resolution imaging, it is possible to observe living tissues at the molecular scale, resulting in images of unprecedented detail. To this aim, the ideal NP should be bright, stable, small, spectrally relevant, versatile, targetable, and non-toxic. These features have been sought after by chemists, physicists and biologists alike for more than a decade but their presence in a single NP has not been achieved to date. The objective of the NanoFUNC project is thus to develop the next generation of NPs displaying all the above properties.We propose to achieve this by conferring targeting properties to the latest all organic NPs of the host laboratory already displaying promising spectral characteristics. We will first validate the functionalisation of these new tools on model cellular systems before applying them to track neurotransmitter receptors deep in intact brain slices of healthy and schizophrenia rat models. We expect this project to impact all communities benefiting from advances in bioimaging including neuroscience, medicine and cell biology as a whole. We thus envisage to patent the obtained NPs for use in marketable bioimaging applications.The transfer of knowledge between the expertise of the host in nanochemistry and that of the experienced researcher in neurobiology provides a unique opportunity to successfully complete this highly interdisciplinary project. Moreover, the mobility of the researcher back to France in an internationally renowned laboratory is sure to enhance her career prospects as she aims to become an independent researcher in the near future. Together, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'EUROCANCER STEMCELL TRAINING NETWORK' (EUROCSCTRAINING) targeting Seventh Framework.

assistant: **Abstract**

The recent identification of tumor initiating (TIC) or cancer stem cells (CSC) has opened a new area of research for scientists interested in cancer. Understanding the biology of cancer stem cells has already unraveled pathways and potential targets.  However, accumulating data has underscored the complexity of the CSC research area and prompts hence the need for well-structured networks to provide expert platforms, rapid exchange of information to train future researchers in this new concept. 10 laboratories from 6 member states with 4 expert enterprises, all at the highest level of cancer stem cell research will unit in a European Cancer Stem Cell Training Network (EuroCSCTraining). Partners, from the public and private sector, have complementary expert experience in this new area, are active members of CSC research, and share dedication in training and dissemination. The EuroCSCTraining coordinator is one of the present coordinators of the Paris CSC Consortium and director of the Institute of PhD schools of University Paris-Diderot. The main goal of this Network is to foster translaboratory and transPhD school training in this new area of Cancer Research. The EurosCSCTraining supervisory board will bring together supervisors of the private and public sector along with representatives of PhD schools to provide eligibility criteria of recruitment, monitor training, and set up individual tutorship for PCD.  The research projects on cancer stem cells will be advertised simultaneously through the EuroCSCTraining Network and the partners’ University. It is anticipated that the EuroCSCTraining network will create a multidisciplinary and multisector structure of training for a new area of research in cancer which will develop research in Europe, foster European collaboration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tuberculosis control in an urban area with high tb / hiv prevalence' (1994-1998).

assistant: **Concept**

* To develop capacity for action research in support of urban TB control.* To develop and evaluate interventions, through action research.* To assess and document the pros and cons of different methodologies used.Expected Outcome* To enhance the understanding of participatory research as applied to urban TB control.* National or regional conference for dissemination of results.* Workshops involving TB programme managers, health care providers, representatives of target groups for the reformulation of sustainable TB recommendations.* Workshops and meetings with policy makers.* Scientific articles written up and published.* Manuals written on TB control to identify and prioritise the problem.* To provide training opportunities and technical support to those involved in TB control in the area of action research.* To quantify the transition coefficients used in the Piot model in Lusaka Urban District.* To identify and explore service, patient and community factors that determine these coefficients.* To validate data collected routinely by the national TB control programme.* To investigate ways to rationalise and assure quality in the use of laboratory services at both reference and peripheral health facilities.* To document the practical advantages and disadvantages of the different methodologies used in the action research and to disseminate these for use by TB control programmes in other countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Stabilization of a flow driven by a rotating magnetic field' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Several modern single crystal growth technologies work with a well-defined melt flow control by external magnetic fields. Rotating magnetic fields turned out to be very attractive since they can effectively homogenize the melt and suppress flow oscillations. The central idea of the project proposal is to complement the action of the rotating magnetic field in order to extend its range of flow stability. Two cases will be studied for it: superposition of a steady magnetic field and an additional rotation of the melt crucible. Preliminary results of the applicant suggest that in both cases a significant flow stabilization can be obtained, and the combination of a rotating magnetic field with a crucible rotation provides flow control possibilities which are qualitatively not accessible by external magnetic fields. The study of these flow control problems needs a coupled effort of experiment and theory. Experiments on flow stability and turbulent properties of such magnetically controlled flows exist at the host institute. With the proposed project they should be supported by theoretical and numerical investigations of the applicant who is one of the leading experts in this field. The knowledge transfer will consist in the theoretical modeling of those flows as well as their numerical implementation. A numerical simulation of rotating flows and their stability requires a tailored numerical approach which standard commercial codes cannot provide. The applicant offers exactly this.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'European evaluation of coercion in psychiatry and harmonisation of best clinical practise (EUNOMIA)'.

assistant: **Objectives**

Coercive psychiatric treatment (involuntary admission, seclusion, restraint and medication) varies widely between European countries with regard to its frequency, type and legal background. These variations are often difficult to explain, which raises the question whether coercive psychiatric treatment might entail unnecessary infringements of patients' rights or might not be therapeutically optimal. Therefore, the goal of the proposed study is to analyse existing variation in co-receive psychiatric treatment in 12 European regions in 12 countries, using naturalistic approach. Data on coercive measures, their influencing factors and out-comes, will be gathered with structured and validated instruments. By integrating this transactional data base with knowledge from legal experts, ethical experts and user organisations, national and European guidelines on best clinical practise of coercive treatment in psychiatry will be drawn up and widely disseminated.