RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Control of disease tolerance to infection by Biliverdin Reductase A' (BILITOLERANCE).

assistant: **Innovation**

The immune system was shaped through evolution, primarily through the selective pressure imposed by pathogens. This led to the emergence of multiple mechanisms that limit the negative impact of pathogens on host health and fitness. The best recognized defense strategy against infections relies on resistance mechanisms that aim at pathogen containment, expulsion or clearance. While crucial for host survival to infection, resistance mechanisms can carry significant trade-offs, often driven by oxidative stress and damage imposed to host parenchyma cells, and in some cases compromising the functional output of host tissues, i.e. immunopathology. Presumably for this reason, resistance mechanisms are coupled to countervailing oxidative stress responses that preserve parenchyma tissue function. These provide tissue damage control without exerting a direct negative impact on pathogens and as such are said to confer disease tolerance to infection. This defense strategy relies on the expression of a number of evolutionary conserved effector genes controlling the pro-oxidant effects of iron and heme, as illustrated for the heme catabolizing enzyme heme oxygenase 1 or the iron sequestering protein ferritin H chain. BILITOLERANCE aims at identifying and characterizing an unexplored and possibly central component of this tissue damage control mechanism that relies on the conversion of the end-product of heme catabolism biliverdin into bilirubin, by biliverdin reductase A (BVRA). The central hypothesis to be tested by BILITOLERANCE is that bilirubin generated by BVRA provides a potent lipophilic anti-oxidant defense mechanism that limits the deleterious effects of lipid peroxidation. Moreover BILITOLERANCE will test the hypothesis that bilirubin also signals via the aryl hydrocarbon r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Innovation and firm performance'.

assistant: **Innovation**

The objective of the study is to assess the impact of innovation on the performance of the firm. Innovation is separated into the firm's own innovations, the innovations of other firms in the same sector as the firm (within sector spill overs) and firms in other sectors (across sector spill overs). By considering innovation according to these different sources, the relative importance of spill overs between firms and firm specific innovations can be assessed. The performance of the firm is defined in a number of ways, work has already been completed relating innovation to export performance, but a wider definition of firm performance will be used in future work, concentrating on the growth of firm productivity (both labour and total factor productivity) and the profitability of the firm. The main policy implication from the study is whether stimulating innovation helps the innovating firm alone, or if it has an impact on other films both within the sector and in other sectors, clearly this has large implications for the effectiveness of subsidies to innovation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Validation of degradation law of pleistocene loam and bruxelian sand under large cyclic deformation with cyclic simple shear tests', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The global purpose of my doctoral work is the characterisation of the phenomenon of degradation induced in the soil by large cyclic angular deformation. Based on cyclic triaxial tests, I want to define a constitutive law describing the decrease of soil resistance in function of the plasticity index, the void ratio and the number of cycles when the soil is solicited by large amplitudes of cyclic deformation. This law will first be validated on basis of cyclic simple shear tests. Then, this law will be applied and validated with an industrial model describing the behaviour of the soil during the vibro driving of a sheet-pile, and the vibrocompaction at deep with a vibrating probe. Training content (objective, benefit and expected impact) The main purpose of the stay at Norwegian Geotechnical Institute is the performance of cyclic simple shear tests. These tests will give me the opportunity to validate the constitutive law derived from the cyclic triaxial tests that I perform in our own laboratory. This validation will generalise the constitutive law. During my stay at N.G.I., I will benefit also from the experience of Dr Dyvik and Mr Andersen who have extensive knowledge about the soil behaviour under cyclic loading and about wave propagation in the soil. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pan-genome Graph Algorithms and Data Integration' (PANGAIA) under Horizon 2020.

assistant: **Objectives**

Genomes are strings over the letters A,C,G,T, which represent nucleotides, the building blocks of DNA. In view of ultra-large amounts of genome sequence data emerging from ever more and technologically rapidly advancing genome sequencing devices—in the meantime, amounts of sequencing data accrued are reaching into the exabyte scale—the driving, urgent question is: how can we arrange and analyze these data masses in a formally rigorous, computationally efficient and biomedically rewarding manner?Graph based data structures have been pointed out to have disruptive benefits over traditional sequence based structures when representing pan-genomes, sufficiently large, evolutionarily coherent collections of genomes. This idea has its immediate justification in the laws of genetics: evolutionarily closely related genomes vary only in relatively little amounts of letters, while sharing the majority of their sequence content. Graph-based pan-genome representations that allow to remove redundancies without having to discard individual differences, make utmost sense. In this project, we will put this shift of paradigms—from sequence to graph based representations of genomes—into full effect. As a result, we can expect a wealth of practically relevant advantages, among which arrangement, analysis, compression, integration and exploitation of genome data are the most fundamental points. In addition, we will also open up a significant source of inspiration for computer science itself.


**Keywords:** Algorithmic bionformatics, computational pan-genomics, graph algorithms, data structures and indexing,  computational comparative genomics, genome data science
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cochlear Optogenetics for Auditory Research and Prosthetics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Disabling hearing impairment (HI) affects 360 million people worldwide and prevalence increases with age. So far, no causal treatment is available for its most common form, sensorineural HI. I propose to establish, characterize, and employ optogenetic stimulation of the cochlea, which provides unprecedented opportunities for auditory research and promises a fundamental advance of hearing restoration.Sound is encoded by spiral ganglion neurons (SGNs) with high frequency-, intensity-, and time-resolution. Hearing can be enabled via electric stimulation of SGNs, which is employed in current hearing restoration with cochlear implants (CIs) and also used in auditory research. CIs enable speech comprehension in most users, but the quality of ‘electric hearing’ is low, with poor frequency resolution. The goal of OptoHear is to overcome this fundamental limitation by increasing the number of independent coding channels via spatially confined optical stimulation of channelrhodopsin (ChR)-expressing SGNs by tens of light emitters along the cochlear axis (cochlear optogenetics). This promises a dramatic improvement in the frequency resolution of artificial sound coding. As proof of principle, we achieved virus-mediated expression of ChR in SGNs, recorded light-evoked auditory activity and demonstrated improved frequency resolution for optical vs. electric stimulation in rodents. We co-developed and implanted optical multichannel CIs and studied their position in the rodent cochlea using X-ray tomography.We will optimize the expression of best-suited ChRs in SGNs, establish multichannel optical stimulation, characterize neuronal responses to cochlear optogenetics along the auditory pathway by physiological and behavioural approaches, and employ cochlear optogenetics for fundamental
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'nanotech x-ray tube' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Luxbright develops next generation x-ray tube technology. The products we are developing for this project include a nano-material cold cathode x-ray tube and advance tube innovations (other internal components). We have applied for patents in key areas and we plan to sell it to medical imaging device manufacturers with the end consumer being hospitals and medical facilities. X-ray tubes are a component within medical imaging devices (x-ray machines). The innovations are derived from a nano-material structure which enables x-rays to be produced through a process called field emission. The other tube technologies allow for other improvements in imaging. For this project, the overall objective (Phase 2) is to reach first sales of our tube technology inclusive of developing a pilot system. First sales will likely be to a mini C-arm (a type of x-ray machine) system manufacturer. Within Phase 1 of this, the objective is to complete feasibility assessments for reaching first sales of x-ray tubes. The specific objectives of the feasibility assessments are as follows: Develop Internal Organization, Market Study, Innovation Strategy Development, IP Management Strategy, Partner Contracting, Develop Business Model and Risk Assessment. The business opportunity stems from the desired solutions to social problems, economic inefficiencies, and technical inefficiencies of today’s conventional x-ray tubes. Conventional tubes generate x-rays using a thermionic mechanism with numerous pitfalls which can be improved. The effects of incorporating the nanoscale structures in this product result in x-ray tubes which generate social value (through safer treatment experiences) and economic value (by allowing hospitals to treat more patients per day in tandem with increased patient satisfaction).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identifying Digital Endpoints to Assess FAtigue, Sleep and acTivities in daily living in Neurodegenerative disorders and Immune-mediated inflammatory diseases', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Fatigue and sleep disturbances are two common and disabling symptoms that affect patients with neurodegenerative disorders (NDD) and immune-mediated inflammatory diseases (IMID). These symptoms are major predictors of poor quality of life and increased healthcare cost. Current questionnaire-based approaches to measure these symptoms have key limitations preventing them from being used as reliable endpoints in clinical trials to evaluate the effect of therapies. IDEA-FAST aims to address these issues by identifying novel digital endpoints for fatigue and sleep disturbances that will provide more objective, sensitive and reliable measures of the severity and impact of these symptoms in ecological settings. Such digital endpoints will not only help to gain insight into the underpinning mechanisms of fatigue and sleep disturbances, but will also vastly improve the efficiency of clinical trials, ultimately reducing the time and cost to bring new therapies to patients.To identify these digital endpoints, we will follow the recommendations of the Clinical Trials Transformation Initiative (CTTI). We will identify the characteristics that fatigue and sleep disturbances will have impact, then select the digital measures (endpoints) to quantify them, followed by choosing the appropriate digital device/technology accordingly. We will then perform a pilot study to prioritise a few of these candidate digital endpoints for validation. We will test the performance of these digital endpoints in two NDD and four IMID in a large longitudinal study during which extensive relevant clinical data will be collected. If these digital endpoints were validated, we will seek support from EMA/FDA for their qualification. Patient users’ perspective, ethical, data privacy, legal and other regulatory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Brain resaerch unit, low temperature laboratory (LTL)' (LTL), addressing dissemination and exploitation.

assistant: **Impact**

Description:The facility has state-of-the-art biomagnetic recording instruments, including a magnetically shielded room, a 306-channel whole-head neuromagnetometer, data collection hardware and software, versatile stimulation equipment, and extremely sophisticated data analysis software. The visitors have access to all these facilities, which allows them to carry out high-quality neuromagnetic measurements on the functions of the human brain. A sufficient number of computer workstations and personal computers are also available. The local staff has good expertise in all areas of biomagnetism and their specialities include neuroscience, physics, engineering, psychology, and mathematics.Application:A yearly call for proposals is published in Trends in Neurosciences and continuously in the WWW pages of HUT/LTL Chairperson of the Users Selection Panel is Riitta Hari. The Selection Panel is advised to use the following criteria when evaluating the Neuro-BIRCH III proposals:1) Scientific importance of the proposed work;2) Feasibility to do the experiment in the Brain Research Unit of LTL/HUT;3) Reputation of the applicant or her/his supervisory group;4) Balance between different geographic areas in Europe.Project Manager:Riita Hari, Brain Research Unit (BRU), Low Temperature Laboratory (LTL), Otakaari 3 a, Espoo 02015 HUT, P.O. BOX 2200, FinlandTel: +358-9-4512952Fax: +358-9-4512969E-Mail: hari@neuro.hut.fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Perception and Action in Complex Environments' to be submitted under Horizon 2020.

assistant: **Abstract**

The PACE research and training programme sits at the interface between basic science, technology and clinics, in order to unveil how humans control and adapt their movements in complex, naturalistic environments.  Such a research agenda has major consequences for understanding how these movements are impacted by specific brain insults and how these impairments can be compensated for via new rehabilitation methods. Improving rehabilitation programmes for sensory and motor disabilities across the lifespan is a major societal challenge in western countries and many obstacles need to be overcome. To provide but one example, with regard to eye-hand coordination of upper limb movement remaining abilities are rarely assessed in stroke patients or sensory-disabled children and this impacts both prognostic estimation and rehabilitation. New technologies, such as robotics or virtual reality, provide an exciting change in perspective to transfer state-of-the-art knowledge from basic research on sensorimotor transformation into the clinical domain. To meet these societal challenges, it is crucial to train a new generation of early-stage researchers in a programme such as PACE where fundamental and applied/clinical research are effectively integrated via collaborative research, doctoral secondments and theoretical courses – in other words, one in which clinicians, neuroscientists, theoreticians and engineers can contribute around a well-defined problem: how humans acquire, lose and recover movement performance. With 8 academic, 1 clinical and 1 private beneficiaries, and 5 partner organizations (4 industrial, 1 in science communication), PACE structures a training and research programme that is both highly interdisciplinary and intersectoral. Our goal is to meet both fundamental and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Valorisation Alliance Linking Laboratories, Enterprises and societY Stakeholders' in the context of a Horizon Europe call.

assistant: **Objectives**

Knowledge valorisation – turnKnowledge valorisation – turning research into societal, economic and policy value – remains fragmented across Europe, with many intermediaries (TTOs, incubators, science parks, clusters, citizen engagement organisations) under-recognised and unevenly skilled, especially in Widening countries.VALLEYS addresses this gap by establishing the European Network of Knowledge Valorisation Intermediaries, directly implementing ERA Action 7 and the Guiding Principles for Knowledge Valorisation. Our mission is to connect, empower and professionalise intermediaries so that they can act as catalysts of impact across academia, industry, society and policy.We will deliver:*A broad and inclusive network of at least 150 organisations from 25+ countries, with ≥30% from Widening regions, structured into five thematic working groups.*A digital Knowledge Valorisation Toolbox, including 20+ open resources and an AI assistant, adopted by 150+ organisations, updated twice yearly, with ≥80% user satisfaction.*Capacity building through +15 training modules, peer-learning workshops and 100 mentoring sessions, training 500+ participants *A mobility scheme supporting 10 staff exchanges across borders.*Cascade funding: 2 open calls (€500k FSTP) funding 25 projects, with ≥30% beneficiaries from Widening countries and ≥70% committing to sustain valorisation beyond funding.*Dissemination and sustainability: 2 major European conferences (300 participants), 5 policy briefs, 10,000+ website visits, and a long-term model embedding the network within IASP structures.The consortium brings together: ATRINEO (innovation management, AI toolbox), SPLORO (cascade funding expertise), St John’s Innovation Centre (training, mentoring, Cambridge incubation hub), 3OC (participatory design,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A generic CMOS-compatible platform for co-integrated plasmonics/photonics/electronics PICs towards volume manufacturing of low energy, small size and high performance photonic devices', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

PLASMOfab aims to address the ever increasing needs for low energy, small size, high complexity and high performance mass manufactured PICs by developing a revolutionary  yet CMOS-compatible fabrication platform for seamless co-integration of active plasmonics with photonic and supporting electronic. The CMOS-compatible metals Aluminum, Titanium Nitride and Copper, will be thoroughly investigated towards establishing a pool of meaningful elementary plasmonic waveguides on co-planar photonic (Si, SiO2 and SiN) platforms along with the associated photonic-plasmonic interfaces. The functional advantages of PLASMOfab technology will be practically demonstrated by developing two novel functional prototypes with outstanding performances: 1) a compact, plasmonic bio-sensor for label-free inflammation markers detection with multichannel capabilities and record-high sensitivity by combining plasmonic sensors with electrical contacts, Si3N4 photonics, high-speed biofunctionalization techniques and microfluidics 2) a 100 Gb/s NRZ transmitter for datacom applications by consolidating low energy and low footprint plasmonic modulator and ultra high-speed SiGe driving electronics in a single monolithic chip. The new integration technology will be verified through wafer-scale fabrication of the prototypes at commercial CMOS fabs, demonstrating volume manufacturing and cost reduction capabilities. PLASMOfab technology will be supported by an EDA software design kit library paving the way for a standardized, fabless plasmonic/photonic IC eco-system.


**Keywords:** photonic integrated circuit, plasmonic waveguide, silicon photonics, CMOS technology, 100 Gb, s electronics, plasmonic modulator, monolithic integration, multi-channel sensing, biomarker detection