RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Supporting Research Ethics Committees for efficient functionality and national accreditation to REview clinical Trials in Uganda and Ethiopia' to be submitted under Horizon Europe.

assistant: **Abstract**

BACKGROUNDThere are few research ethics committees (RECs) with capacity to review and provide oversight for clinical trials in Sub-Saharan Africa (SSA), and hardly any national accreditation systems used to evaluate the quality of review by these RECs. Although digital protocol submission systems improve RECs efficiency, up to 48% RECs in SSA still use paper-based systems. Additionally, many (single country) clinical trials in SSA are not registered with any internationally recognized clinical trials registry. The SECRET project seeks to address these challenges in Uganda and Ethiopia, by establishing national RECs accreditation systems, building capacity of RECs to review clinical trials (including during outbreaks and emergencies), establishing national clinical trials registries linked to the Pan African Clinical trial registry (PACTR), and developing digital protocol submission systems.METHODOLOGYThe SECRET project includes partners that have worked together in other EDCTP-funded projects, to address the identified gaps through four objectives and six work packages. We will leverage the experience of the Uganda National accreditation system to establish a national accreditation system for Ethiopia and accredit at least two RECs in Ethiopia and two in Uganda. We will also leverage the expertise of the PACTR to set up the Uganda National Clinical Trial Registry. Nuvoteq that have experience in digital solutions for health care services will support Ethiopia to set-up the digital protocol submission systems. We shall also leverage the expertise of Makerere University bioethics training unit and the National Drug Authority of Uganda to build capacity for clinical trial review and oversight for the RECs to be accredited. The Uganda National Health Research Organisation a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Robust mixed-signal design methodologies for smart power ICs'.

assistant: **Concept**

Smart power circuits and technologies contribute in a unique way to the realization of the system-on-chip concept by combining digital logic with analogue signal processing and power and high voltage switching. The main objective of this project is to enable a robust design of smart power circuits leading to a first-time-right design with built-in reliability and thus avoiding very costly over-dimensioning. To achieve this ambitious goal, compact models will be built that accurately describe power device operation including extensions to verify safe-operating area conditions. The devices to be modelled include the lateral DMOS, vertical DMOS and LIGBT fabricated in bulk silicon and power devices realized in advanced SOI technology. Model extensions are planned for device ageing due to hot-carrier injection, statistics due process variations, device matching and layout effects such as large area closed-cell matrices.An important feature will be an accurate description of the internal device temperature plus a coupling to package thermal models and EMC modelling. The final goal is to achieve a system level design flow for smart-power SoC using complex transistor level simulations or generated black-box models. Full smart power circuits will be simulated with the new design flow and models will be assessed and calibrated against experimental measurements. The gain in performance and robustness will be quantified.The project therefore aims at providing the EC power" industrial community with new, highly robust tools to design and characterize smart power devices and circuits. This will strengthen and significantly advance ECs position as a fast growing, world supplier of smart power technologies. Design and fabrication of highly reliable and efficient Smart Power circuits i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Search for Novel Non-Fermi Liquid Models and Materials' (EXOMETALS).

assistant: **Innovation**

The standard theory of electrons in metals, Landaus Fermi liquid theory from 1956 has been very successful in predicting the low-temperature properties of many metals. Its greatest success was its ability to describe many heavy fermion metals, whose name comes from the huge apparent masses acquired by their conduction electrons. However increasingly many metals have been synthesized where Fermi-liquid predictions fail. They are called non-Fermi liquid (NFL) or exotic metals. Prominent examples are certain heavy fermion compounds and high-temperature superconductors. These materials are of interest because of the emergence of new properties that could be used in future technologies. In most cases NFL behaviors lack the understanding, as only a handful of solvable, microscopic models describe NFL phenomena. To make strides I will construct a novel class of NFL quantum impurity models. Quantum impurity models describe the interaction between local degrees of freedom, like a spin, and the surrounding conduction electrons. The simplest NFL quantum impurity model was considered to be the so-called two-channel Kondo model (2CKM). One of the new quantum impurity modelswhich I call the one-and-a-half-channel Kondo model and whose low-energy solution gives the topological Kondo effecthas less degrees of freedom and is, in this sense, simpler than the 2CKM, yet it also exhibits NFL behavior. Generally, this new family of NFL quantum impurity models includes all those overscreened Kondo-type models where the number of conduction electron species are not integer multiples of the number of impurity states. I will study the new quantum impurity models using Wilsons numerical renormalization group method (recognized by the 1982 Nobel Prize). My further aims are to experimentally realiz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Low cost tracking and data management solution for biopharma cold chain logistics' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The Danish company Globe Tracker International (GT) is revolutionizing supply chain visibility and profitability as a leading provider of data sharing, data analytics and global asset tracking.GT has developed a fully functional hardware/data management system that is ready to be deployed globally and is currently being tested in commercial trials in the reefer market. GT has partnered with global OEMs, container manufacturers and data transmission companies to help commercial expansion. For this project, GT has identified the the pharma product delivery market as a high value segment in which demand exists but where its solution needs adaptation to meet customer and regulatory requirements. The demand stems from the need for safe, secure and efficient distribution of pharma products in a strictly controlled and refrigerated environment in order to protect the integrity of the drugs. Today temperature deviations endanger patient safety and increase costs. In addition, sabotage and counterfeiting damages safety and brand values. This need is especially apparent in the fast growing biologics market that already represents a third of blockbuster pharma shipments and over half of clinic trials.The feasibility study will (1) identify the most promising pharma market niche for entry that will ultimately open up growth into all other temperature/security/counterfeit relevant segments and (2) define the technical design for its final products to deliver the largest possible economic benefits to the supply chain. The feasibility study will help to understand how the multi-layered stakeholders need to be involved. GT will evaluate the competitive landscape, analyse pricing and ROI models and monitor its FTO position, while it is building a patent portfolio throughout Phase1 and P
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nutrient-gene interactions in human obesity: implications for dietary guidelines' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

An epidemic of obesity afflicts European populations, posing a major public health challenge due to the associated severe problems and inability to manage them. The project aims at improving understanding of interaction between nutrition (befit intake) and genetic variations. Six hundred obese and 120 reference subjects are invited to a scrutiny of dietary habits and relevant life style aspects, a 3-day dietary standardisation at 37% of energy as fat, a 1-day clinical investigation with a test meal with 60% fat, and a 10-week hypo caloric dietary intervention with 20-25% fat. Metabolic and hormonal responses to the test meal, changes during the intervention period in body weight and composition, and in gene expression in adipose tissue will be related to genotypes of selected new candidate genes. Such knowledge may improve treatment and prevention of obesity.Overall outcome: Outcomes in terms of core publications focussing on:-Postprandial response to the high fat test meal-Weight loss on low vs. medium fat diet- Metabolic, anthropometrical and life style related predictors of weight loss and predictors of differential response to low and moderate fat intake- Identification of candidate genes and candidate gene variants- Genotyping of the whole study population for a large number of gene variants in candidate genes- Quantitative gene expression in adipose tissue, effect of hypo energetic diet intervention with low or medium fat intake- Gene expression profiling in adipose tissue, effect of hypo energetic diet intervention with low or medium fat intake- Identification of novel candidate genes or gene variants for obesity- Integrating the results on phenotypic characteristics with genotyping and gene expression data Specific outcomes for further exploitation: Randomised,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Automatic tracking of golf games for improvement and training purposes, using GNSS receivers, wearable sensors and Earth Observation information' (GOLFTRACKER) targeting Horizon 2020.

assistant: **Abstract**

The overall objective of GOLFTRACKER is to offer golfers a product to automatically track of golf shots during the game, collecting and combining data from GNSS receivers, wearable motion sensors and Earth Observation mapping. The resulting product, will be based on a general wearable device implemented on top of existing COTS hardware (e.g. Samsung GEAR, Apple Watch) and a specific tracking device for golfing using a sensor fusion approach. The product will allow golfers to improve their game, providing statistics for post analysis, peer benchmarking tools and training recommendations. The proposed innovation is aimed at equipment segment and training segment (golf lessons) with estimated revenues of 3300 Million euros in Europe. This phase1 project focus on exploring the business opportunity related to the automatic tracking, by developing a innovation strategy supported EGNOS/Galileo and Sentinels that will lead to patent registration. The activity aims also to assure user’s involvement, collecting the feedback from early adopters and promote the product's features to reach a wider community. A business survey will be performed, consolidating the results on the product business plan. The work to be performed is led by BLUECOVER with the participation of third-parties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Development of new design and test methods for whiplash protection in vehicle collisions (WHIPLASH II)'.

assistant: **Concept**

Yearly more than one million European citizens suffer neck injuries from car collisions. These injuries often give rise to long lasting consequences for the individuals. It is expected that whiplash injuries can be reduced significantly by improvements in vehicle design, in particular the seat/head restraint system and the restraint system. As a result of the 4th Framework WHIPLASH project, a test and design method for whiplash protection has been developed, however, this method considers the loading phase of rear-end collisions only. The technical and scientific objective of this new project is to develop evaluation and design methods to minimise the incidence and risk of neck injuries in all important accident conditions and to take the rebound phase of the loading phase also into account. Main innovations in this project include:- implementable design guidelines related to the seat/head restraint system and the restraint system for improved whiplash protection- test methods and a new crash dummy to assess the whiplash protection offered by a vehicle- computer models to support the industrial design process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'PREParE SHIPS - PREdicted Positioning based on Egnss for SHIPS' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The objective of the project ‘PREParE SHIPS’ is the development and demonstration of a collaborative resilience navigation solution. It aims to develop and enhance existing software solution by exploiting the distinguished features of Galileo signals as well as combining it with other nautical information on internal as well as external parameters and sensor technologies. The final navigation decision support tool implemented consists of collaborative exchange by ship2ship communication of dynamically predicted future position based on resilient position from Galileo receivers. This will increase safety and efficiency significantly and will be the base of future autonomous operations.Besides the use of vessel on board sensors, ‘PREParE SHIPS’ will also make use of data learning of earlier ship behaviour to exchange near-future positions with vessels in the vicinity and VTS centers (Vessel Traffic Services) to increase safety and improve decision making. In order to define the correct requirements for the PREParE SHIPS combined positioning solution, a collaborative automated vessel application will be defined and developed. The vessel application will rely on the high availability positioning solution and use it to couple its various navigational systems with ship2ship/ ship2shore and aggregate information received from other connected vessels. As there will be a transition period where a lot of vessels are neither connected nor automated, solutions having high impact during low penetration are in focus. ‘PREParE SHIPS’ will implement and demonstrate a fairway geo-fencing with high precision positioning taking into account various data sources (e.g. wind and current) as well as a traffic monitoring and predicted positions so it can allow for safe decisions based on robus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Giant-leaps during tumorigenesis: Dissecting saltatory evolution in cancer ‘in the making’', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Tumorigenesis is an evolutionary process driven by gradual mutation acquisition to confer selective advantages to somatic cells. DNA rearrangements are the most common cancer driver mutation, outnumbering base substitutions. Rearrangements amplify, disrupt and fuse genes or alter their gene regulation, ultimately driving adaptive changes to initiate cancer, metastasis and therapy resistance. Cancer genomics has revealed that most of these alterations arise as complex genomic rearrangements (CGRs), where a multitude of changes arise in a short time. While in most cases deleterious to the cell, in rare cases CGRs confer an adaptive malignant phenotype in one giant-leap through saltatory evolution events (SEEs)  reminiscent of the hopeful monsters theorised by Goldschmidt. Given their potential to overcome strong selective barriers, it has been proposed that SEEs draw the line between benign lesions and lethal cancer, and understanding their mechanisms is thus fundamental to tumour biology. However, the identity of cells undergoing SEEs has remained elusive, with cancer genomics studies focusing typically on long-established cancers rather than early or even initiating cancer cells. Intriguingly, CGRs are largely explained by cascades of atypical cell nuclei (i.e., nuclear atypias) fueling rearrangement formation, providing an opportunity to study SEEs.Building a novel automated AI-driven framework that couples imaging and single-cell multi-omics, we will leverage nuclear atypias as a phenotypic indicator to dissect principles and mechanisms of SEEs in the making, and advance fundamental cancer biology. Using highly controllable cell lines and organoid models of colorectal cancer (CrC), a tumour thought to be driven by SEEs, we will unravel pathways, genetic contexts and c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Highly sensitive, high spatial resolution, high throughput and full elemental mapping: simultaneous fs-ns DP-LIBS/LA-ICPMS'.

assistant: **Objectives**

Multi-elemental mapping, allowing the characterization of the elemental distribution in heterogeneous samples at high spatial resolution (~µm scale), are opening new applications in many fields. As two laser ablation-based techniques, laser induced breakdown spectroscopy (LIBS) and laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS), are becoming more and more attractive, due to the advantages such as rapid, sensitive, and high spatial resolution mapping. Especially, they are complementary to each other, where LA-ICPMS offers more sensitive analysis while LIBS can analyze the elements that are difficult or impossible for LA-ICPMS analysis, such as H, O, N, C, or halogens. Full elemental fast mapping applications can be achieved with simultaneous LIBS-LAICPMS technique. However, due to the different detection mechanisms for these two techniques, the optimal laser operation conditions were different, where LIBS typically require higher laser pulse energy than LA-ICPMS. Therefore, the LIBS signal under standard LA-ICPMS conditions are generally relatively low. In this project, to enhance the LIBS signal without significantly affecting ICPMS analysis, combination of double pulse LIBS in an orthogonal configuration and LA-ICPMS is proposed, where a second laser pulse (ns) is used to reheat the plasma plume/aerosol induced by the first laser ablation pulse (fs), to carry out highly sensitive, high spatial resolution, high throughput and full elemental mapping. To perform simultaneous optimal analysis by LIBS and LA-ICPMS, a high-performance ablation cell with optimized optical collection lenses will be designed and developed. Further on, the analytical setup will be established and corresponding analytical methodology for full elemental imaging will be deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Rapid and Reliable Detection of Foodborne Pathogens by Employing Multiplexing Biosensor Technology' in the context of a Seventh Framework call.

assistant: **Objectives**

Pathfinder is an important research project focused on development of innovative means of detecting important pathogenic organisms  associated with food poisoning. This will be achieved using biosensor technology capable of detecting many different pathogens simultaneously. To achieve the main goal the Marie Curie Fellow, Dr. Nitsara Karoonuthaisiri from Thailand will bring her skills in microarrays and pathogen detection and lead a team of scientists at the Host Institute at Queen’s University Belfast. The Fellow will work closely with the Institute Director, Professor Chris Elliott, an eminent European researcher in the field of advanced diagnostics on this two year project at the host institution followed by one year return phase. The outcomes of this research will be extremely important to Europe as food poisoning affects many millions of citizens each year and improved diagnostics has been identified as one of the key topics requiring more research activity. Dr. Karoonuthaisiri has been motivated to apply for this prestigious Fellowship to work in a European centre of excellence to enable transfer of her skills & knowledge to an EU research team.