RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Analysis of Neuregulin-1 function in the maturation of cortical GABAergic interneurons: Implications for the etiology of schizophrenia' (GABACORT) targeting Seventh Framework.

assistant: **Abstract**

Schizophrenia is a psychiatric illness affecting nearly 1% of the population that is though to arise as a consequence of abnormal brain development.  Structural deficits are relatively subtle in schizophrenia; however, there is evidence for a reduced volume of the neocortex, probably linked to perturbed development of the neuropil, and significant alterations in GABAergic neurotransmission in patients with schizophrenia.  Recent genetic studies suggest that Neuregulin-1 (Nrg1) and its receptor ErbB4 are susceptibility genes linked to the disorder.  Interestingly, our preliminary observations demonstrate that ErbB4 is specifically expressed by GABAergic interneurons during the postnatal development of the cerebral cortex. The goal of this study is to determine the role of Nrg1/ErbB4 signalling in the maturation of GABAergic interneuron, using interneuron specific ErbB4 mutant mice, in order to get insights into the etiology of schizophrenia.  We plan to address the function of Nrg1/ErbB4 using cell culture techniques, in utero manipulations and analyses of interneuron-specific ErbB4 conditional mutants.  In brief, we will test whether Nrg1 influences the axonal development of control or ErbB4 mutant cortical interneurons in primary cultures.  In addition, we will study the morphological development of individual ErbB4-deficient cortical interneurons in vivo, by in utero electroporation of Cre/GFP plasmids in the place of origin of most cortical interneurons, the medial ganglionic eminence.  Furthermore, we will establish the role of Nrg1/ErbB4 in synaptogenesis both in cell cultures and in vivo, scrutinizing the development of GABAergic terminals in control and ErbB4 conditional mutants by confocal analysis, electron microscopy and electrophysiological techniques.  Final
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Sector-coupling hub for circular use of thermal and industrial waste'.

assistant: **Innovation**

Within HURRICANE a sector-coupling circular hub centered around the ArcelorMittal Ghent site will be created. We will target efficient resource management together with the recovery and utilization of squandered industrial waste heat and water. Together with ArcelorMittal Ghent’s ongoing initiatives, this will lead to a reduction of energy, water and raw materials by at least 20%.Thanks to the ongoing projects taking place within and around the Ghent site, the site is already well connected to many other industries like waste suppliers, chemical producers (ethanol offtake & H2 waste gas), renewable power producers, and wastewater treatment. It has become a multi-sectoral hub leading to efficient implementation of industrial symbiosis concepts. The Ghent site has a significant amount of recyclable energy, material and water that allows this symbiosis. These aspects are not only from the steel making processes, but also from other operations taking place in the mentioned “multi-sectoral” hub. This hub, can be further enhanced with the integration of waste heat with its ongoing initiatives.Our solution aims at developing and demonstrating novel heat recovery (heat exchanger) and upgrading (heat pumps) solutions from selected operations and then coupling it with the internal and external off takers by means of a heat grid. With digital tools, aspects like broadening the district heating network, and adapting the heat demand profile of the buildings to better match the intermittent of the waste heat can be optimized.  Finally, an integrated software tool for circular hubs that combines the different tools and data produced at the different operations will be developed and validated. Through two virtual demonstrations and a circular hubs blueprint the replication potential wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Digital Do It Yourself' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Digital do it yourself (DiDIY) is a new socio-technological phenomenon in which the widespread availability of digital devices supporting the convergence of physical and informational components and the growing accessibility of knowledge and data through open online communities presage scenarios in which the distinction between users and producers of physical artefacts is fuzzy and new opportunities and threats emerge. DiDIY-related technologies and social practices amplify the creativity and skills of individuals who affordably develop digitally self-made objects, e.g., unique-by-design objects designed by 3D modelling software and generated by 3D printers or networked smart objects equipped with microcontrollers dealing with context information via sensors and actuators. Two network effects catalyse DiDIY: what is custom produced by an individual could be the outcome of contributions from a world-wide community of developers sharing their interest towards open innovation, thus operating as knowledge multiplier; what is made available here and now by a smart object could be the aggregation of signals from a set of sources in the network, thus operating as information extender.In this (presumed) industrial revolution the project aims at:* setting a conceptual framework to explore the impact of DiDIY,* producing information, models and guidelines to support education and policy making on DiDIY that, while enabled by technology, should be driven by social and cultural strategies.The project will study how DiDIY is* reshaping organization and work, education and research,* impacting on social and legal systems* changing creative design and ethics.The development of a systemic interpretation is the challenge for the multidisciplinary project team, which will collaboratively
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Exploring asymmetric neural dynamics – a study on Drosophila’s visuomotor processing'.

assistant: **Concept**

Asymmetry is a fundamental principle of nervous system organization and can be seen across species in various forms, ranging from subtle differences in neuron size, synaptic connectivity, or axonal branching, to more pronounced cases where entire brain regions are lateralized to one hemisphere. These asymmetries play a critical role in cognition, species-specific behaviors, and neural circuit physiology. While studies in model organisms and human brain imaging have provided some insights into the role of asymmetry in behavior, the underlying neural and computational mechanisms remain largely unexplored. Navigational tasks, such as locating food or mates and driving a car rely on these neural asymmetries. In Drosophila, dorsal cluster neurons (DCN) exhibit asymmetric axonal branching between hemispheres and are crucial for navigation between targets. Flies with more asymmetric DCN wiring show improved performance when orienting toward an object, and inducing asymmetry in originally symmetric wiring enhances this ability. In this project, I aim to test for the first time the computational, physiological, and behavioral advantages of neural circuit asymmetries within a single animal model. I hypothesize that structural asymmetry within a circuit influences its physiology by promoting specific neural activity dynamics across hemispheres. To test this, I will combine anatomical reconstructions, functional calcium imaging in freely behaving flies, and computational modeling. My expertise in linking specific neural circuits to visually guided behaviors uniquely positions me to uncover how structural asymmetry benefits neural physiology. The rapidly advancing tools and resources in Drosophila research make DCN an ideal model for this study. Overall, this integrated approach pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a standardised cup anemometer suited to wind energy applications' (1994-1998).

assistant: **Concept**

Objectives The primary objective is to produce the optimal design for a standardised, cup anemometer which is suited to the requirements of the wind turbine industry and is essentially free from the design faults which are associated with all of the instruments currently commercially available. A secondary objective is to prepare a classification system which will allow users of anemometry in the wind energy industry to select anemometers suited to specific required applications. Technical approach The approach of the project will be largely experimental with a very clear practical objective. Computer based or analytical modelling will be undertaken to support the experimental work. The project will involve technical investigations in the areas of: - sensitivity of cup anemometers to wind speed components outwith the horizontal plane in wind tunnels and in the field. - bearing friction, with particular regard to temperature effects - dynamic response and its effect on the accuracy of mean wind speed and turbulence measurements These investigations will be used in the context of two main target deliverables, these being - a new classification scheme for cup anemometers - a new, high accuracy, standard design for a cup anemometer suited to wind energy applications Expected achievements and exploitation The technical achievements of the project will be: - the production of a design for a standardised anemometer, specifically suited to wind energy applications, - comprehensive verification that the new design is ostensibly free from errors which are currently generic, - the development of a thorough knowledge of how various geometric parameters affect the sensitivity of cup anemometers to out-of-plane wind speed components, - evolution of the concept of a cup anemometer cla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Higgs boson search and detailed study of four fermion background using the delphi detector at Lep 5' to be submitted under Fourth Framework.

assistant: **Abstract**

The host team of the DAPNIA/SPP is part of a European collaboration in particles physics, called DELPHI from the name of the particle detector handled by the collaboration at the LEP collider at CERN (Centre Europeen pour la Recherche Nucleaire). LEP provides collisions between electrons positrons that produce the Z boson, which is the particle responsible for the neutral weak interaction. The Z data sample recorded at LEP is already the largest in the world, which allows to make a very precise study of the Z properties that translates into precise tests of the weak interaction theory. The project aims at studying the production of Higgs boson in the Z decays. The Higgs boson is a particle predicted by the theory as the remnant of the process which gave masses both to the particles responsible for the weak interaction and to the matter constituents. Looking for the Higgs boson is theferore one major subject of today particle physics. The proposed project will focus on a detailed study of the backgound present in this search. A correct background understanding and estimate is indeed essential to extract a reliable signal. The data sample available at the end of 1995 should allow such a study of the four fermion process which is one of the main background sources, yet not fully understood. The results will be included in a review paper on the Higgs search in DELPHI at LEP phase 1.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'The use of racial antidiscrimination laws in Belgium: a gender perspective'.

assistant: **Concept**

The research aims to evaluate the effectiveness of Belgian racial antidiscrimination laws by focusing on the target group in a gender perspective. The main hypothesis is that men and women make different uses of the law. This is because they develop different representations of the legal system and experience different types of discrimination in their interaction with the society in which they live and work.This project seeks to innovate compared to the state of the art by: focusing on the factor of gender in shaping perceptions and choices among ethnic minority groups, and their reaction and use of anti-discrimination legislation when faced with racial discrimination; extending the 'legal consciousness studies' to anti-discrimination policy in its application to migrants and non-nationals.The research will be based on a study of formal complaints, observation of the actors (lawyers and victims), semi-directive interviews of foreign nationals and members of ethnic minorities and written interviews based on keywords used in legal and daily contexts.The research aims to support the formulation and the implementation of EU Equality and non-discrimination policy by: Improving our understanding of the phenomenon of gender and racial discrimination; developing practical tools for administrations, NGOs and specialised bodies ( e.g. a guide to good practice) for evaluation and exchange of good practice, particularly in relation to gender; establishing the basis for comparative research with other m ember states.A fellowship with the Gender and Migration Group at ULB, Brussels will enable the researcher to deepen her expertise by offering a multidisciplinary environment in the field of gender and migration (psychology, economics, history, sociology, law) and the possibility to c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Two dimensional modeling of direct methanol fuel cells', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The direct methanol fuel cell (DMFC) is projected as a potential power source for vehicular traction and static power due to its simplicity of design. The current understanding of the behavior of the DMFC is mainly based on zero-dimensional (0-D) and one-dimensional (l-D) models which are frequently inadequate for performance prediction and optimization. Almost in all literature models, material parameters are considered independent from local transport conditions.Overall to fully understand the behavior of the fuel cell and enable effective optimization and design of materials for the cell requires models which incorporate the influence of structure on transport properties and electrocatalytic properties and an extension to, at least, two dimensions. The research programme is aimed at understanding the overall behavior of Direct Methanol Fuel Cells, through the development and assessment of predictive models, mainly in 2-D, and through validation with extensive experimental data set.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Molecular Mechanisms of Stem Cell Self Renewal' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Over the past few years, a view has emerged that pluripotency in mouse embryonic stem cells (ESCs) is cell-autonomous and does not depend on external signals. This was based on work that showed that a combination of a small molecule ERK inhibitor with a GSK3 kinase inhibitor was sufficient to maintain self-renewal, in absence of any growth factors. I have now discovered that autocrine or paracrine signalling via the Wnt pathway plays an essential role in ESC self-renewal, and is required to inhibit their differentiation towards primitive ectoderm. Moreover, I have discovered that the combination of Wnt protein with the cytokine LIF is sufficient to support the maintenance and derivation of germ-line competent ES cells in fully defined conditions not containing any other growth factor. Thus, two different fully defined conditions both maintain self-renewal, but do so in different ways. However, the intracellular events downstream of those conditions must both converge on the self-renewal machinery. By analyzing and comparing these events in both systems, unmatched synergy in zooming in on the relevant entrances into the self-renewal machinery can be obtained. I propose to analyze the events downstream of these two sets of self-renewal stimuli, in an effort to identify novel self-renewal genes. The downstream effects of the self-renewal stimuli will be analyzed using gene expression profiling, ChIP-Seq, and phosphoproteomic approaches. Combining and comparing the different data sets will identify candidate genes that will be screened in a self-renewal assay designed for high sensitivity and throughput. Genes that pass this test will be further analyzed for their roles in proliferation, survival, and differentiation in an effort to compartmentalize the self-renewal machine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Sustainable PoLymers from Algae Sugars and Hydrocarbons' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The 4-year SPLASH project will develop a new biobased industrial platform using microalgae as a renewable raw material for the sustainable production and recovery of hydrocarbons and (exo)polysaccharides from the species Botryococcus braunii and further conversion to renewable polymers. The project comprises 20 partners of which 40% SME and several large corporates plus universities and research institutes.Two bioproduction platforms will be explored: (1) green alga Botryococcus braunii on its own and (2) thegreen microalga Chlamydomonas reinhardtii, to which the unique hydrocarbon and polysaccharides producing genes from Botryococcus will be transferred. SPLASH will deliver knowledge, tools and technologies needed for the establishment of a new industry sector: Industrial Biotechnology with algae and/or algal genes forthe manufacture of polyesters and polyolefins. The building blocks for these polymers will be derived from the sugars (polyesters) and hydrocarbons (polyolefins) exuded by the algae: adipic acid from galactose,2,5-furandicarboxylic acid from glucose, rhamnose and fucose, 1,4-pentanediol from rhamnose and fucose, ethylene from ‘green naphtha’, propylene from ‘green naphtha’.The conversion of ethylene and propylene to polyolefins is common technology, and will not be included in the project. The sugar-derived building blocks will be converted to new condensation polymers, includingpoly(ethylene 2,5-furandioate) (PEF). End-use applications include food packaging materials and fibres for yarns, ropes and nets. The project encompasses (1) development of Botryococcus as an industrial production platform, (2) Systems biology analysis, (3) Development of procedures for production, in situ extraction and isolation, (4) product development.