RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Coordination of European Phytosanitary (Statutory Plant Health) Research' under Sixth Framework.

assistant: **Concept**

Statutory plant pests and diseases can cause serious economic and environmental damage in Europe. Although the legislation that underpins phytosanitary (plant health) policy for these statutory pests and diseases is determined at the EU level, the research that supports policy development and implementation is primarily done at the national level and is currently uncoordinated. An ERA-Net (EUPHRESCO) is therefore proposed for research policy development and implementation in the field of statutory and emerging plant pests, diseases and invasive species (but not: GMO's). The proposal has the full support of the EC Council Working Party of Chief Officers of Plant Health Services, EC DG SANCO, the EC Standing Committee of Agricultural Research and EPPO, who recognise the need to optimise national phytosanitary research budgets and prevent the progressive erosion of phytosanitary science expertise; this is in an era of increasing threats from quarantine pests, pathogens and invasive species due to globalisation of trade, EU enlargement and climate change. EUPHRESCO will draw together, for the first time, national research programmes to better serve the needs of EU phytosanitary science and policy. EUPHRESCO has Partners from 14 Member States and 3 Associated States; it represents all of the key national phytosanitary research funders within the EU context. EUPHRESCO will achieve its objectives through an ambitious step-wise approach, as follows: - Map, analyse and share information on national phytosanitary research programmes. - Establish proven instruments for procuring, managing and appraising trans-national phytosanitary research activities. - Develop common research agendas based on shared priorities for developing and implementing a joint programme at the end of the E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Oxidative phosphorylation in brain mitochondria implications for neurodegeneration' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Thresholds exist in brain mitochondria whereby their respiratory chain complex activities need to be reduced by certain percentages before major changes in oxidative phosphorylation will occur. Synaptic mitochondria have lower complex thresholds than non-synaptic mitochondria, a finding which has important implications for neurodegeneration in general. This project will investigate mitochondrial respiratory chain complex thresholds in neuronal and astrocytic cell lines. The objectives are to: 1. Establish the techniques that have been learnt during the initial fellowship in the return-grant-laboratory. 2. Estimate the threshold levels that exist in neuronal and astrocytic cell lines. 3 Deplete cells of the antioxidant glutathione and to record any effects on the respiratory chain complex thresholds. 4. Use antioxidants (ascorbate, tocopherol, lazaroids) and growth factors (NGF, BDNF) in an attempt to increase threshold levels in neuronal and astrocytic cells, thus providing a possible means of neuroprotection and astroprotection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Elucidating the Role of Subcellular GPCR Nanoswitches in Signaling Specificity' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

G protein-coupled receptors (GPCRs) relay extracellular information across the cell membrane to mediate most physiological cell functions. Many cell-surface GPCRs stimulate the production of cyclic adenosine monophosphate (cAMP), a diffusible second messenger, to elicit receptor-specific, long-range cell functions. However, given the mobility of second messengers, this canonical model fails to explain receptor-specific functions across multiple GPCRs that signal via cAMP. This application proposes that GPCRs, in dramatic contrast to the second messenger concept, form highly-localized, nanometer-size cAMP signaling units at various subcellular locations, i.e. subcellular GPCR nanoswitches. At these locations, GPCR nanoswitches tightly control cAMP signaling at the nanometer scale in a receptor- and location-specific manner. These nanoswitches enable cells to retain the spatial-ID of every cAMP molecule and, thus, allow precise, spatially encoded, and receptor-specific cell functions even in the presence of multiple co-activated receptors. The combination of cutting-edge technologies such as genetically encoded Foerster resonance energy transfer (FRET)-based biosensors, fluorescence-lifetime imaging microscopy (FLIM)-FRET multiplexing, and advanced proximity proteomics, will enable mapping the architecture and dynamics of these subcellular GPCR nanoswitches at nanometer scales. This proposal will then explore how endogenous GPCR nanoswitches control insulin secretion from pancreatic beta-cells in response to endogenous incretins as well as licensed obesity drugs. This will establish the physiological relevance of subcellular GPCR nanoswitches.If successful, this proposal has the potential to revolutionize our understanding of cell signaling and to fundamentally transform
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Quantum Cavity Electro- and Opto-Mechanics' (Q-CEOM), addressing dissemination and exploitation.

assistant: **Impact**

Nanomechanical oscillators have recently been realised in the quantum regime, by coupling them to a single mode of the electromagnetic field. Platforms using both superconducting microwave circuits and optical cavities have been employed—separately—for this purpose. Based on the PI's extensive contributions to these developments, we propose to explore the intriguing conceptual and experimental prospects of hybrid multimode systems involving microwave, mechanical and optical modes in the quantum regime, thus unifying the fields of quantum cavity optomechanics and electromechanics.To reach this ambitious goal, an optomechanical system involving two optical modes and one mechanical mode will serve as testbed for quantum conversion and tripartite entanglement protocols. Particular attention will be devoted to the evasion of mechanical thermal noise through noise-resilient schemes, relying, for example, on mechanically dark Bogoliubov modes. This will enable the conservation of quantum coherence in spite of the inevitable coupling of the mechanical device to a thermal environment. The protocols, once established, will be transferred to a hybrid multimode system, consisting of a superconducting microwave resonator, a nanomechanical oscillator, and an optical cavity mode. In this system, we will explore unprecedented opportunities to transduce, entangle and amplify microwave and optical modes through a mechanical device.The specific implementation proposed here opens new avenues for the ultralow-noise processing of microwave signals, with potential applications in radio astronomy or magnetic resonance imaging. In the quantum sciences, it bears great promise to overcome the dichotomy between superconducting circuit platforms for information processing, and flying optical photon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Growing Long Distance - RNA Control of Neuronal Extension' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Neurons are the longest cells, extending axons over distances that can reach four orders of magnitude larger than their cell body diameters. How can they achieve such long distance growth? After initial engagement with target cells, neurons undergo stretch-induced elongation as the nervous system matures with the growth of the organism. The molecular mechanisms enabling such prodigious growth are unknown. Based on strong preliminary evidence, we tested the hypothesis that both the initial elongating and later stretch-induced axon growth act via a shared RNA localization mechanism.Very strikingly, we identified a specific subset of polyadenylated repeat element RNAs, hereby termed growth-inducing SINEs (GI-SINEs), as key growth regulators. GI-SINEs are induced from AP-1 promoter-associated extragenic loci, and interact with ribosomal proteins and the axon growth regulating RNA binding protein nucleolin, in neuronal cytoplasm. We will elucidate how this intrinsic mechanism controls neuron growth, determining (1) how known elongating growth regulators affect stretch-induced growth; (2) how local and global protein synthesis regulate neuron growth control; and (3) how growth regulates the GI-SINEs and how they regulate different growth modalities.We will apply a multidisciplinary suite of techniques and approaches to these challenges, including a new technology for characterization of nascent proteomes developed in-house. The proposed project will provide ground-breaking and fundamental mechanistic insights on neuronal growth, and will establish novel methods that will be widely applicable. Moreover, establishing that a repeat element RNA is an intrinsic effector linking AP-1 transcription to translation regulation is a breakthrough finding that opens new horizons for cell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Search for New Phenomena, Materials and Applications Using Van Der Waals Assembly of Individual Atomic Planes' to be submitted under Horizon 2020.

assistant: **Abstract**

Many layered materials can be disassembled into isolated atomic planes, similar to graphite that splits into graphene layers. A few years ago, we demonstrated that such atomic planes – two-dimensional (2D) crystals – can be stacked on top of each other making so-called van der Waals (vdW) heterostructures. This has ignited a new field that is booming and has not disappointed in delivering interesting science. However, research efforts have so far involved only relatively simple structures that are assembled from 2 or 3 crystals and employ only a very limited number of 2D materials. This proposal is based on several recent experimental and technological advances by the applicant’s group. These include access to many new 2D crystals that have become available if their (dis)assembly is done in an inert atmosphere. Little remains known about these materials. We have also mastered the art of vdW assembly to make heterostructures containing dozens of different layers with control of their crystallographic alignment. Dedicated measurement techniques aimed at investigation of the resulting atomically thin structures and devices have been developed, too. The applicant plans to exploit these advances and push the research field forward in several new directions that include the search for 2D materials exhibiting unusual properties and novel functionalities, creation of multilayer vdW devices with designer characteristics and the assembly of artificial thin films with unique electronic spectra. Some of the proposed directions (e.g., studies of molecular transport through angstrom-scale capillaries) are nearly guaranteed to bring a large amount of new science and potential applications, whereas other directions (e.g., artificial films exhibiting enhanced superconductivity) are more
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Design tool for prediction of flicker from wind turbines' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives The aim of the project is to develop and validate software to predict, at the design stage, the flicker produced by a wind turbine. Flicker is a term used to quantify rapid fluctuations in voltage experienced by consumers connected to electricity distribution systems. Wind turbines can produce greater power fluctuations than other forms of generation, and the resulting voltage fluctuations and flicker may become a serious limitation to wind generation on rural electricity systems. The objectives of the project are: - To develop a software design tool, compatible with existing wind turbine design packages, to predict flicker given the machine design parameters, for any specified wind conditions and network parameters; - To validate the design tool against measurements on representative wind turbines; - To investigate the difference in flicker between fixed speed machines and variable-speed stall-regulated machines, which have dynamic behaviour of particular importance for flicker. Technical Approach Initialy the best choice of generator models to provide sufficient accuracy and speed of simulation will be investigated. Models for variable-speed drives will also be investigated, for the particular case of variable-speed stall-regulated turbines. The best method to represent the external electricity network will be established. Measurements of flicker will be made on two large wind turbines. The measurements will then be used to modify and validate models of the two turbines, including the generator and network models developed previously. The design software developed will be aimed at wind turbine designers and electricity utility engineers. Expected Achievements and Exploitation The work is intended to reduce the cost-of-energy from wind turbines, and reduce t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Trophic Networks at the dawn of tetrapod Terrestrialisation' (TNT) targeting Horizon 2020.

assistant: **Abstract**

The Late Devonian (380 to 360 Myr ago) is marked by the apogee of the terrestrialisation process that consists in the establishment of complex continental ecosystems. After the invasion of land by plants, and by arthropods, it is the rise of tetrapods (four-legged vertebrates) at the end of the Devonian that will change Earth’s continental ecosystems forever. Their complete terrestrialisation is only recorded by the Carboniferous and the Late Devonian represents thus the ideal period to understand processes related to tetrapod terrestrialisation. While the taxonomic richness, the phylogenetic relationships and the paleoenvironmental settings of Devonian tetrapods are better understood yet, a serious gap remains in our knowledge of the palaeoecological context. This is a major evolutionary issue, as tetrapods obviously did not evolve in an ecological vacuum and faunal interactions must have been critical driving forces for the transition from water to land.  To tackle these issues, the ‘Trophic Networks at the dawn of tetrapod Terrestrialisation’ (TNT) project focuses on the trophic relationships in eight crucial and diverse Devonian vertebrate assemblages containing tetrapods. It blends calcium isotope analyses with statistical analyses of ecomorphological characters to reconstruct the trophic position, trophic interactions, and paleoecology of Late Devonian vertebrates under different environments and climates. Because Recent trophic networks provide a comparative basis for understanding Past ecosystems, two Recent localities, with fossil analogues, are also studied in the scope of the TNT project. The TNT project aims to estimate the predation pressures exerted on tetrapods and if these pressures acted as a driving force for their terrestrialisation.


**Keywords:** C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Fracture mechanics of microstructured composites incorporating intrinsic length-scales'.

assistant: **Concept**

Inspired by biological systems, artificial composite materials nowadays may be micro-tailored with a hierarchical structure, or may be produced with sculptured chiral structures, or with stabilized negative-stiffness inclusions. The result is that these new materials can achieve surprisingly excellent mechanical properties.The technological application of these new high-performance composite materials is limited by fracture nucleation and propagation at nano and micro scales. In fact it is very difficult to simultaneously achieve high values of strength and toughness, for which ordinarily there is a trade-off. The aim of this project is the development of new models of fracture mechanics for innovative composite materials, bridging together the different length-scales and thus overcoming the main limitations of linear fracture mechanics (LEFM). In fact, since LEFM is a scale-free theory, it is unable to characterize materials with microstructure and to describe size-effects at small scales.The goal will be achieved by a novel multiscale approach to fracture mechanics combining continuum and discrete modelling. In particular, at the microscale the heterogeneous microstructure of the composite material will be described as a continuum micropolar medium incorporating appropriate length-scales, thus capable of capturing size-effects. At the nanoscale the discrete structure of the material will be described in terms of lattice models in order to understand the mechanism of dissipation and the properties of waves generated by propagating cracks. The continuum and discrete modelling will be combined through the concept of structural interface, where a discrete structure representing the interface of finite thickness is embedded in a continuum body.These models will have an imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Many paths to separate sexes: the genomics of sex-determination in the Hawaiian Wikstroemia' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Life on earth has undergone several major evolutionary transitions, but perhaps none so striking or relevant to our daily lives as the origin of separate sexes. Yet, despite intense study for over 100 years, understanding how and why genes determining sex evolve - and the consequences for the chromosomes harboring them - remains an open problem in evolutionary biology. One obstacle is that most previous work has focused on ancient sex chromosome systems, like those found in mammals, where recombination suppression and genetic degeneration has obliterated any signs or signals of how genetic sex-determination evolved in the first place. But here, flowering plants (Angiosperms) come to the rescue! Compared to animals, Angiosperms exhibit a staggering diversity of reproductive forms, and have transitioned from combined (hermaphroditism) to separate sexes (dioecy) many times in their evolutionary history. The goal of this project is to understand the genomic changes giving rise to at least two and possibly three parallel transitions from hermaphroditism to dioecy via the evolution of new sex chromosomes within an endemic Hawaiian radiation of the flowering plant genus Wikstroemia (Thymelaeaceae; 12 spp.). Using a combination of genomics, bioinformatics, gene expression, and greenhouse experiments, I aim to achieve three key objectives: (1) locate and fully annotate sex-linked regions of the genome associated with each form of dioecy; (2) clarify the systematics of this radiation and study the biogeography of sex-linked genes, and the relative times of origin and whether/how recombination suppression has evolved for each form; and (3) determine what genes/developmental pathways are involved in sex-determination in these closely related lineages. This fascinating radiation off
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cs2 spectroscopy by photo-association of laser cooled cesium' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The accuracy of the resonance of a photo-associative collision is essentially given by the relative kinetic energy of colliding species, which varies from a few thousand Gigahertz at ordinary temperature to a few Megahertz for cesium cooled atoms. By using Cs cold atoms obtained in a Magneto-Optical Trap (MOT), we will develop a high resolution spectroscopy of long range molecular states of Cs2. In a cesium MOT, the photo-associative collisional process of two free cesium atoms in the dimer molecule Cs2*, in a rotovibrational excited state, will be realized by a first laser. Signature of photo-associative process will be obtained by photo-ionization of Cs2 in Cs2+ using a second leser. The ions will be selectively detected through a time-of-flight mass spectrometer. The theoretical interpretation of the spectroscopic lines will give access to the long range molecular potential curves of Cs2.