RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tuning emission of charged excitons in two-dimensional transition metal dichalcogenide monolayers' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Transition metal dichalcogenide (TMD) monolayers constitute an attractive material platform due to additional degrees of freedom in encoding and processing quantum information. Currently, the use of these degrees of freedom in valleytronics is hampered due to the low valley polarization of the neutral exciton at room temperature. Recently, charged excitons have been demonstrated to exhibit high valley polarization even at room temperature albeit with low quantum yield and have a need for sophisticated charge doping techniques. This action proposes a novel electro-optical interface based on electron doping of TMD monolayers.  I suggest to use the electric double layers to control the formation of charged excitons, and to use complex nanoantennas to enhance and collimate generated emission. My goal is to develop a quantum device merging fields of electrochemistry, photonics, plasmonics and TMD materials,  giving practical access to new degrees of freedom for future valleytronic applications. The objectives are to demonstrate the exciton charging in TMD monolayers using a custom-built electrochemical cell and to tune electrically charged-exciton emission through the manipulation of the Fermi level, i.e., chemical potential. I aim to use the tuning of emission energy for coupling the charged exciton with a narrow resonance of a complex nanoantenna. This antenna will increase the extraction efficiency by directing the emission of charged excitons and enhancing their generation rate. Furthermore, I aim to explore the chirality of valley polarization and address the emission of charged excitons for their directional coupling with plasmons in high quality wedge waveguides based on crystalline gold micro-flakes. The overarching aim of my action is the development of a novel brig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Imaging The Topological Defects of Light-Induced Phases in Quantum Materials' to be submitted under Horizon Europe.

assistant: **Abstract**

Quantum materials host many exotic and useful phases, and harnessing these states has spurred tremendous research effort. However, the full potential of quantum materials lies in the rich landscape of higher-energy hidden phases, those which are not thermally accessible. Ultrafast laser excitation has recently emerged as a way access these hidden phases, leading to the idea of re-writing material properties on demand, but these states usually only survive for hundreds of picoseconds. Thus a key outstanding question remains: how can we stabilize light-induced phases? One key mechanism which can stabilize a phase is topology. The ultrafast phase transitions induced by femtosecond laser pulses naturally lead to the generation of topological defects. These defects, which can only relax after propagating until they encounter another topological defect, could either offer a route to stabilizing light-induced phases or impede their formation, and have been invoked in both contexts to explain many observations. However, actually imaging these nanometer scale defects on the femtosecond to nanosecond timescales required for light-induced phases has not been possible, and so the role of topological defects in light-induced phases remains unclear.In KnotSeen I will perform the first real space imaging of topological defects in light-induced phases using coherent XUV imaging methods, which provide the necessary spatial, temporal, and spectral resolution to map topological defects at the nanoscale and out of equilibrium. I will map the creation, propagation, and destruction of topological defects in two important cases: quenched superconductivity in the cuprates and light-induced phases in the manganites. A novel data analysis approach will be used to distinguish repeatable from stoc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ERASysAPP - Systems Biology Applications' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The main objective of the ERANET proposal “Systems Biology Applications – ERASysAPP” (app = application = translational systems biology) is to promote multidimensional and complementary European systems biology projects, programmes, and research initiatives on a number of selected research topics. Inter alia, ERASysAPP will initiate, execute and monitor a number of joint transnational calls on systems biology research projects with a particular focus on applications – or in other words so called “translational systems biology” research approaches (application-oriented and/or industry-relevant). The joint call proposals and their respective topics will be on applied aspects of complex biological processes in microorganisms, plants, and animals. As common feature, all addressed proposal topics will tackle biological and physiological processes of common interest in the field of life sciences and biotechnology.In order to reach our ambitious goals, ERASysAPP has been outlined to initiate novel activities and impulses for SB in the ERA. Taking past successful developments and achievements into account, ERASysAPP will be able to continue and build on work, which has been performed by the previously funded successful ERANET on SB, ERASysBio and its spin-offs ERASysBio+, SysMo and SysMO2 (www.erasysbio.net). This is advantageous, since it allows for the efficient use of past experiences and tangible results of ERASysBio and will guarantee for maximum synergistic effects. Although building on the improvements of ERASysBio, ERASysAPP will provide a bundle of novel aspects, ideas, activities and sustainable new features to push SB towards new challenges and horizons. Apart from setting up joint transnational calls and giving impulses for industry to apply more SB approaches, ERAS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'RNA-mediated virulence gene regulation: Identification of novel antibacterial compounds'.

assistant: **Objectives**

All kingdoms possess a large fraction of RNA-based regulation. We identified several small non-coding regulatory RNAs (ncRNAs) in the human bacterial pathogen Listeria monocytogenes that controlled virulence by a direct RNA:RNA interaction. My group have also identified several 5´-untranslated RNAs (5´-UTRs) known to control expression of their downstream mRNA by a switch mechanism triggered by certain metabolites, specific compartments of the host or by different temperatures.In the suggested project, we will analyze the mechanism by how various RNA-species function on a molecular level by biochemical and genetic approaches. By constructing mutations (deletion and base-substitutions), the role of the regulatory RNAs and their targets during pathogenesis will be pin-pointed using different virulence model organisms. For 5´-UTRs binding specific metabolites, we will add non-metabolic analogs to examine if such molecules can block the function of the 5´-UTRs and hence infection. The core structure of one identified ncRNA will be used as a scaffold to develop an RNA interference system in bacteria.At least one RNA-helicase has been shown to be essential for bacterial motility and growth at 4°C. It is being purified to test its in vitro properties at mRNA targets and at different temperatures. Its in vivo role will be analyzed by genetic techniques.Bacterial resistance against different antibiotics is an increasing problem worldwide. We have identified one pyridine molecule specifically targeting listerial virulence gene expression and its mechanism of action will be revealed by genetic and biochemical techniques. A diffusible, although yet unknown molecule, with bacteriostatic activity was observed and its nature and mechanism will be revealed mainly by biochemical experim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dynamic regulation of paracellular channel gating' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Epithelial paracellular, i.e., tight junction, permeability is largely defined by the integrated functions of claudin proteins that can either seal the paracellular space or form highly-selective conductance channels. The importance of claudins is exemplified by the many human diseases caused by barrier dysregulation and claudin mutations. The host laboratory recently reported the first measurements of single channel tight junction currents, thereby demonstrating that claudin channels transition between open and closed states. The central hypothesis of this application is that claudin channel activity is regulated by specific molecular interactions. Unfortunately, the trans-tight junction patch-clamp method developed by the host laboratory is extremely labor intensive and unable to capture more than a small section of a single tight junction, making it unsuitable for comprehensive analyses. To overcome this obstacle, we first aim to develop a nanopillar array chip that will supersede the patch-clamp method. Cells grown over and around the nanopillars will form tight junctions above the nanoelectrode at the tip of each nanopillar. This will make it possible to measure large numbers of single-channel events over many junctions. The second aim will exploit the nanopillar chip to define the conductances and gating activities of claudin proteins and the mechanisms by which they are regulated. This novel technology will also allow others to analyze claudin function in health and disease. The nanopillar chip and data generated using this tool will accelerate our understanding of tight junction biology and enable development of channel modulators that, in a manner analogous to the advances enabled by transmembrane ion channel modulators, will lead to novel therapeutic approache
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Monte Carlo studies of protein induced curvatures in bilayer membranes' (1994-1998) under Fourth Framework.

assistant: **Objectives**

One of the major challenges is to understand the structural behavior and functionality of cell membranes. Its exceptional mechanical properties combine perfectly flexibility and stability. Elasticity could also provide a mechanism for lipid-prote interactions that can lead to a lipid-mediated selective protein aggregation. This process is also of direct importance in the design of novel biomaterials. From the physical point of view, one of the most fascinating phenomena is the shape changes and local instabilities of cell membranes. Objective: By performing Monte carlo simulations of coarse-grained models, we'll be able to deal with systems with a large number c molecules. It will allow us the study of phase transitions and demixing processes, such as protein segregation in membrane and how this process is driven by the generation of curvature in the membrane. Basic contents: To study of the effect of membrane proteins on the curvature of lipid-bilayers we'll proceed as follows: 1- Develope a coarse-grained model membrane that reproduces experimental behavior. 2-. Study the effect of protein insertion. How does a bilayer membrane change its local curvature at a particular site where single protein is inserted?, how the geometry of the protein is related to the succesful local bending of the membrane?. 3- Study the lipid-mediated protein interaction process in: (a) Flat membranes and (b) Fluctuating surfaces. 4-.Determine whether protein clustering is driven by the development of curvature. Training content (objective, benefit and expected impact) The training aspect of this proposal focusses in getting a deeper knowledge in the main scientific area of the applicant and acquire new methods and techniques of analysis for the system described. Links with industry / industr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of ultrasonic guided wave inspection technology for the condition monitoring of offshore structures' (OPCOM).

assistant: **Innovation**

The project will develop a revolutionary new technology to continuously monitor the integrity of structures such as offshore oil production platforms and offshore wind turbine towers using Ultrasonic Guided Wave (UGW) Technology. The proposal answers the c all for 'New life-cycle optimised, safety and environmental technologies for industrial production'. The majority of the offshore wind turbine towers are at the start of their life cycle (being currently installed in their thousands) whilst the offshore oi l and gas platforms are at the end of their life cycles (between 25-40 years old). Both are in urgent need of inspection. The development of Ultrasonic Guided Wave (UGW) Technology for inspecting offshore structures has the potential to impact upon the lif e cycle cost of vital components of the infrastructure through: 1.Continuous monitoring of structural integrity from fabrication to scrapping. 2.Extending the life of offshore structures, therefore reducing depletion of resources for new builds. Current methods of inspection of offshore oil and gas platforms and wind turbine towers have the following major drawbacks: (1 ) Can only inspect a few cm2 area. (2) Need to be deployed by divers in hazardous sea conditions. (3) Need expensive Remotely Operated Ve hicles for deployment. (4) Cannot inspect the base of the wind turbine towers and offshore platform structures where large loads from sea currents cause fatigue cracks. The above lack of inspection technology has led to major disasters and loss of life aft er large oil platforms have structurally failed. A number of growing examples include the Alexander L. Kielland, which failed through undetected cracking, killing 123 oil and gas workers. Total commercial loss was 500 million Euros. Unfortunately the lack of ad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The value of european patents : empirical models and policy implications based on a survey of european inventors' in the context of a Fifth Framework call.

assistant: **Objectives**

This Project will produce a survey of 10,000 EPO patents to acquire information not contained in the patent files. This will produce a largely original data base which the network will combine with existing complementary data bases (available with the network participants) to produce empirical papers (both econometric an qualitative studies) on topics that have been to a good extent neglected because most of the existing research is based on information drawn from the patent documents. The topics that we will cover include the determinants of the value of European patents; the organisation of innovation in Europe ; APRs and the markets for technology. The Project will also draw policy implications from the empirical studies at all three territorial levels, viz. European, national, and regional. Many of the issues dealt with in this Project are in line with the subjects highlighted by the Communication Towards a European Research Area" ."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Imaging tumor vessels as a marker for p53 mutation status in cancer' (IMaP) targeting Horizon 2020.

assistant: **Abstract**

The p53 protein is mutated in over 50% of cancers. Because its expression often promotes tumor growth and is associated with resistance to treatment, there has been great interest in treating cancers based on p53 mutation status. However, the use of p53- targeted therapies requires knowing the mutation status. DNA sequencing is one approach, but requires invasive biopsies, and newer sequencing techniques still face technical hurdles. Non-invasive imaging techniques offer an alternative approach for detecting mutation status. Given that p53 regulates blood vessel growth, and that vessel imaging is used clinically to monitor response to cancer therapy, I hypothesize that tumor vessels could be used as an imaging marker to identify p53 mutation status. To test this hypothesis, I will measure relationships between p53 mutations and vessel structure/function using my expertise in 3D cell biology, vessel imaging, and image analysis and the unique expertise of the host lab in p53 biology, proteomics, and flow cytometry. The objectives of this interdisciplinary work are: 1) to screen the effect of p53 mutants on vessel structure in vitro; 2) to characterize the molecular response of endothelial cells to p53-targeted therapies; and 3) to image the structure and function of vessels in mutant p53 tumors in vivo. If a relationship is found between p53 mutation status and tumor vessel features, then it could lead to the development of the first imaging marker of p53 mutation status. This marker could help clinicians select p53-directed therapies to personalize therapy for each cancer patient. Apart from scientific impact, the proposed work will also expand my career prospects and scientific network in Europe. Under the mentorship of the host lab supervisor Prof. Sir David Lane, who
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Explore the role of NK cells in post-treatment control of HIV-1 infection: impact of genetic background and early treatment initiation' to be submitted under Horizon Europe.

assistant: **Abstract**

Antiretroviral therapy (ART) blocks HIV replication but cannot eliminate viral reservoirs that originate viral rebound if ART is discontinued. However, the host laboratory originally described some individuals, post-treatment controllers (PTC), capable to durably control viremia after ART discontinuation. More recently, the group has found that HLA B*35 alleles (usually associated with rapid progression in the absence of ART) are paradoxicaly overrepresented in PTCs and are accompanied with an MHC immunogenetic fingerprint (termed Bw4TTC2 by the lab), related to KIR-education of NK cells. The proposed work aims to better characterize transcriptional and functional signatures of NK cells in PTC and other people with HIV (PWH), their evolution since primary infection, during ART, and after ART discontinuation, and in regard of immunogenetic factors. These will be done in three different settings: (i) crossectional analysis in groups of people with well-characterized HIV status; (ii) longitudinal samples from the biobank of the primate-VISCONTI study (pVISCONTI); (iii) prospective study of samples from individuals on ART since primary HIV infection and carrying B*35 Bw4TTC2 , who will undergo ART interruption (ATI) in the context of the ANRS RHIVIERA01 clinical trial. Overall, this proposal should unveil the phenotype and functional activities of NK cell subsets more relevant to post-treatment control, the influence of early ART initiation and of immunogenetic factors. This information may provide important insight for the development of new immunotherapies aiming HIV remission.


**Keywords:** NK cells, HIV-1, Innate immunity, Infection control
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Humidity passive harvest technologies' assessment and optimisation' under Fifth Framework.

assistant: **Concept**

Aim of the present project would be the assessment of traditional passive techniques of irrigation based on atmospheric humidity harvest, which were used indifferent countries of the Mediterranean Basin and the Atlantic coast of Africa. That assessment would take into account the local climate conditions in order to evaluate precisely the efficiency of these techniques of humidity harvest. Further the project aims to formulate appropriate policies and accompanying measures assuring the propagation of that sustainable techniques which consitute a low cost possibility of valorisation and environmentally sound sustainable exploitation of numerous coastal and arid areas of the Mediterranean Basin and the Atlantic coasts of Africa.* Present proposal has been corrected according the reargues of the evaluators