RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Towards a Quantitative Theory of Integer Programming'.

assistant: **Concept**

Integer programming (IP), i.e. linear optimizationwith integrality constraints on variables, is one of the most successfulmethods for solving large scale optimization problems in practice.  While manyof the base IP problems such as the traveling salesman problem (TSP) orsatisfiability (SAT) are NP-Complete, IPs with tens of thousands of variables areroutinely solved in just a few hours by current state of the art IP solvers. The main goal of this proposal is to develop a quantitative theory capable ofexplaining when and how well different IP solver techniques will work on a widerange of instances. Here we will study many of the principal tools used to solveIPs including branch & bound, the simplex method, cutting planes and roundingheuristics. Our first direction of study will be to develop parametrized classesof instances, inspired by the structure of realistic models, on which branch &bound and the simplex method are provably efficient. The second researchdirection will be to develop alternatives to ad hoc rounding heuristics andcutting plane selection strategies with provable guarantees and provide theirapplications to important classes of IPs. Lastly, we will explore the power andlimitations of IP techniques in the context of algorithm design by comparingthem to powerful techniques in theoretical computer science and analyzing theirworst-case performance for solving general integer programs.  While the mainthrust of this proposal is theoretical, it will be complimented by anexperimental component performed in collaboration with well-known experts incomputational IP, both to gain valuable insights on the structure of real-worldinstances and to validate the effectiveness newly suggested approaches. Theproposed research is designed to make breakthroughs in our quantita
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Innovating Secure and Efficient Border Management Through Vehicle-Integrated Technologies'.

assistant: **Innovation**

AutoBorder focuses on developing and implementing innovative solutions for border checks specifically designed for vehicles. The approach leverages cutting-edge technologies, including advanced biometrics and in-car sensors integrated with the car's Infotainment and Control Electronics (ICE) system, to streamline the border-crossing process. By utilizing Digital Travel Credentials (DTCs) and pre-registration systems, the project aims to enhance security while significantly reducing waiting times at land borders.Beyond border checks, the technology enhances passenger security through identity monitoring, real-time alerts for unauthorized access, and predictive analytics for threat detection. This dual-purpose approach improves identity verification and passenger safety during travel, advancing security and connectivity across Europe.Leading actors in several relevant fields actively participate in the project, including biometrics and security experts, car manufacturers and researchers.The project builds on prior EU initiatives (e.g., SMILE, D4FLY, EINSTEIN) and, as a RIA project, targets a Technology Readiness Level (TRL) of 5–6 for most components, with some at TRL4. Validation and demonstration will occur in relevant environments, not connected to actual border systems. Solutions must comply with GDPR, the AI Act, EU travel regulations, and other legal and ethical standards. A dedicated legal/ethical partner will ensure compliance, while social aspects like acceptance and human rights will be addressed.End-user involvement is critical, providing feedback to align solutions with practical needs and enabling pilot demonstrations and validations. AutoBorder involves several EU and non-EU end-users, and has foreseen pilot studies at 2 external EU BCPs (UK-France and Moldo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mechanisms of synaptic growth and plasticity' in the context of a Horizon 2020 call.

assistant: **Objectives**

My long-term goal is to understand the cellular and molecular mechanisms that govern synaptic growth and plasticity, and how dysfunction in these pathways contributes to disease. Neurons are the most morphologically diverse cell type whose morphology determines many functional aspects of a neuronal network. The primary shape of a neuron is established during axon and dendrite outgrowth and synapse formation, but is subject to subsequent modifications by physiological events. In response to changes in synaptic activity, neurons can alter both pre and postsynaptic elements of the synapse. Defects in synaptic morphology and in activity-dependent plasticity are a hallmark of several neurodegenerative and cognitive disorders. It is therefore critical to know the basic mechanisms by which neurons acquire their shape and change it in response to activity, and to dissect the genes that regulate these processes. To address these questions, this proposal is divided in the following aims:1) To dissect the postsynaptic role of the Ral/exocyst pathway in synaptic growth and activity-dependent plasticity2) To uncover novel regulators of neuronal membrane trafficking .My strategy is to use the relatively simple nervous system of Drosophila to uncover novel cellular and molecular mechanisms that control synaptic development and plasticity, in order to understand how membrane traffic is regulated to form and modify neuronal structures. Because 75% of all human disease genes have related sequences in Drosophila and nearly a third are predicted to have functionally equivalent counterparts, I expect that these studies in Drosophila will contribute to the dissection of the mechanisms that, when disrupted, may lead to disease. This will help identify points of intervention, therefore directi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Improvement of the quality of the wastewater in the operations of degreazing and de-oiling in textile finishing by the installation of an on-line control and regulation system' (1994-1998).

assistant: **Innovation**

Textile matter preparation processes in particularly degreasing and de-oiling generate a lot of pollution which provides: - on the one hand from impurities contained in natural fibres (wool) or added on synthetic fibres (alone or mixed in knitted fabrics) for technical reasons; - on the other hand, chemicals and auxiliary products which allow to remove dirt on the fibre but they stay in a major part in the bath preparation. Nowadays these operations represent 30 to 60% of the overall pollution in a complete treatment (preparation, bleaching, dyeing...) and 20 to 50% of the amount of water required for removing dirt and various products. Two main aims are being pursued as part of the project: - implementation of an on-line control and regulation system to optimise these preparation operations and to decrease at short term applications which are made in an empirical way - improving results of treated articles and targeting environmental standards to perform quality of waste water (reduction of the amount of water used after these preparation operations, decreasing of quantities of textile auxiliary products).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Coding for terabit-per-second fiber-optical communications' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The goal of this project is to improve the performance and efficiency of fiber-optic communication systems that operate at terabit-per-second data rates. This goal will be realized by analyzing and optimizing the error-correcting codes used by these systems.Our first objective is to derive a finite-length scaling law which characterizes the code performance as a function of the code length (in bits). As a major novelty, we consider deterministic codes, which can fulfill the stringent requirements of terabit-per-second systems in terms of target bit error rates and hardware implementation. A scaling law can be used, for example, to rapidly assess the code performance in order to identify trade-offs and optimize system parameters. It thus constitutes a fundamental tool in order to design next-generation systems and to further push the limits of fiber-optic data transport.Our second objective is to reduce the decoding complexity. Current algorithms waste resources (power) because they do not exploit valuable information that is exposed during the decoding process. We minimize complexity by designing efficient component code selection strategies. We will also theoretically analyze the expected complexity savings, in particular in the regime where the noise level approaches the code’s threshold. The development of low-complexity decoding algorithms plays an important role in the design of energy-efficient fiber-optic systems decoding contributes substantially to the overall energy consumption. Therefore, this work will help to ensure that future data traffic demands can be met in a sustainable way.Our results are broadly applicable also for Flash memory systems, vehicular communication networks, and the computation of sparse fast Fourier transforms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Tamoxifen-inducible in vivo mouse system for studying p53 tumour suppression' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Fusion proteins between the hormone binding domain of a mutant mouse oestrogen receptor (ERTM) and the tumour suppressor p53 are strictly tamoxifen-dependent. To study the role of p53 in suppressing carcinogenesis in vivo protein expression of a tamoxifen-dependent domi- nant negative DN p53 ERTM construct will be targeted to specific tissues in transgenic mice. Wild type pS3 will then be functionally inactivated in target tissues by administration of tamoxifen to affected animals and spontaneous carcinogenesis will be awaited or mice will be subjected to various known carcinogenic regimes. In a second approach, by homologous recombination in ES cells mice will be created in which one copy of wild-type p53 has been replaced with a gene encoding the tamoxifen-de- pendent p53 ERTM protein. The remaining intact p53 allele will be sporadically lost to give rise to tumours which will then be analysed towards their responsiveness to p53 tumour sup- pression by administration of tamoxifen and thereby activating the p53 ERTM protein. These investigations may provide the basis for a successful gene therapy of cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Accelerate Sustainable Enabling of Oxygen Evolution Reaction Catalyst for Water Electrolysis' under Horizon Europe.

assistant: **Concept**

Large scale synthesis of efficient, durable, and environmentally friendly electrocatalysts is key for commercialization of proton exchange membrane water electrolysis (PEMWE), which is a vital route for renewable H2 production. State-of-the-art PEMWE is limited by the high price of the electrocatalysts which are composed of Ir, Pt and Ru (40% of fabrication costs of PEMWE). Against this background, the project ABLE OER aims to develop, characterize, and electrochemically evaluate low-cost, and up-scale supported electrocatalysts from commercial and recycled precursors using microwave continuous flow synthesis (MWCFS). The specific objectives of ABLE OER are to provide proof-of-concepts on i) synthesis of active and robust supported-OER catalyst, which reduces Ir loading by 80% at equivalent activity; ii) incorporation of abundant nano ceramics (as support material) and secondary PGMs for OER catalyst to reduce material cost by 70%; iii) an up-scalable continuous OER catalyst synthesis process, which lowers the production cost by 50%. The novel catalyst structure and the associated synthesis process will accelerate technological advancement and societal adoption of the PEMWE technology. My experience in inorganic materials and electrochemistry combined with the expertise of the host group in electrocatalysis for water splitting and recycling will synergistically contribute to achieving the ambitious aims of this project, which will be implemented at the University of Southern Denmark. I will learn new techniques in up-scale production of catalysts, mature my skills as an independent researcher, and increase my network to nurture international collaborations. The results of this project have the potential to greatly reduce the cost of H2 generated from renewable sources a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Increasing the fitness of tumor-infiltrating T cells for cellular immunotherapy' (TIL-FIT), addressing dissemination and exploitation.

assistant: **Impact**

Adoptive T cell therapies (ACTs) are emerging as a promising strategy to treat cancer. Tumor-infiltrating lymphocytes (TILs) are expanded ex vivo, selected for recognition of neoantigens, further expanded and then infused back into patients. This procedure requires extensive culturing and expansion of TILs during which many T cell clonotypes are lost. As tumor-reactive TILs are often exhausted and tend to be overgrown by functional, non-specific T cells in culture, the chance to identify potent tumor-reactive T cells dramatically decreases. Moreover, extensive expansion of T cells diminishes their anti-tumor activity and persistence in the body after adoptive transfers. Thus, improving the fitness of T cells is crucial to increase the success rate of ACTs and make this therapy accessible to a broad spectrum of cancer patients. Our first aim is to increase the fitness of T cells by designing metabolic and pharmacological interventions based on proteomic profiles of TILs from patients with liver cancer. Second, we will use machine-learning algorithms for the extraction of signatures to predict whether TILs grow well in culture, require and respond to metabolic interventions, or cannot be revitalized and do not grow at all. To deal with non-growing T cells, we aim at establishing a microfluidics-based workflow to graft the entire T cell receptor (TCR) repertoire from thousands of non-growing TILs onto fast growing Jurkat cells. After selecting Jurkat cells that recognize neoantigens, their TCRs will be expressed on naïve T cells obtained from the patient’s blood that are fit and suitable for ACT. This project will contribute to a better understanding of the T cell response to liver cancer and help increasing the success of personalized ACTs for solid tumors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Testing Suspension Seats for End-stop Impacts' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The principal objective of this project was to develop a laboratory method for measuring and evaluating the effectiveness of suspension seats for controlling the whole-body vertical vibration transmitted to the operators of off-road vehicles in conditions that may result in excessive suspension travel.Idealised input motions were defined for testing suspension seats of fork-lift trucks, agricultural tractors, forestry vehicles and earth-moving equipment. These are based on a sinusoidal function modulated by a half-sine envelope.A laboratory method has been defined for testing suspension seats, using an artificial load, so as to avoid the exposure of human subjects to a high vibration dose. The magnitudes of the test stimuli are progressively increased from a level that results in a predefined minimum vibration dose value (VDV) on the seat load, until the measured VDV reaches a predefined maximum. Criteria have been developed for measuring seat performance, based on the rate of increase in the VDV on the seat load, as a function of the increase in the VDV at the seat base.Inter-laboratory tests showed that the test procedure is practicable, and discriminates between seats with good and poor performance.Non-linear mathematical models have been developed, making it possible to predict the effect of modifications to seats on test outcomes. These models are being made available to seat manufacturers so as to help them optimise the characteristics of seat suspensions and end-stop buffers.The test method has been described in test guidelines that are drafted so as to be compatible with, and complementary to, tests for continuous vibration isolation in current suspension seat test standards.ts cBackgroundSuspension seats isolate vehicle operators from potentially hazardous vert
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Addressing the Roles of Tachykinins in the Control of Ovulation: Focus on the Substance-P/Tachykinin Receptor Type 1 (Tac1/Tacr1) System' under Horizon 2020.

assistant: **Concept**

Reproductive health is deteriorating worldwide, via as yet unknown mechanisms. The most common cause of in/subfertility in women is ovulatory dysfunction; anovulation being associated to conditions as polycystic ovary syndrome, hypothalamic amenorrhea and premature ovarian insufficiency. Hence, better understanding of the mechanisms controlling ovulation is mandatory for improved management of reproductive disorders. While hypothalamic GnRH neurons are the major output pathway for the brain control of ovulation, upstream Kiss1 neurons, particularly in the rostral hypothalamic area in rodents, have been suggested to be crucial for the timed activation of GnRH neurons and generation of the preovulatory surge of gonadotropins that drives ovulation. However, the major regulators of this Kiss1/GnRH pathway remains ill defined. Substance P (SP, encoded by Tac1), a member of the tachykinin (TAC) family that acts via the receptor, NK1R (encoded by Tacr1), has been shown to centrally regulate gonadotropin release, and, according to our preliminary data, might modulate the pre-ovulatory surge in mice. Yet, the patho-physiological relevance of SP/NK1R signaling in ovulatory control needs to be defined.Here, we will apply functional genomics and virogenetic approaches to assess the roles and mechanisms of action of SP/NK1R signaling in the control of ovulation, with special attention to its actions in Kiss1 and GnRH neurons. To this end, we will apply (i) virogenetic-driven Tacr1 silencing in Kiss1 and GnRH neurons; (ii) tracing techniques to map Tac1 neuronal projections to Kiss1 and GnRH neurons; and (ii) chemo-genetic manipulation of Tac1 neurons, via excitatory and inhibitory DREADDs, coupled to monitoring of gonadotropin secretion and ovulation. Our project, which is based on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Aged people integration, mobility, safety and quality of life enhancement through driving' (AGILE) under Fifth Framework.

assistant: **Objectives**

In western society the older population is increasing, thus leading to a greater participation of older persons in traffic. This project focuses on two key milestones:i) developing the required knowledge and tools to establish rational policies for delivering certification of fitness to drive andii) helping as much as possible older age groups to continue driving safely, as enhanced mobility leads to increased well-being for them.AGILE aims to develop a new set of training, information, counselling and driving ability assessment tools for the elderly, evaluating their full range of physical, cognitive, behavioural and interactional abilities and not just checking a few sensory and motor functions (as is currently the case). To realise such a challenging task and achieve the targeted goals, a multi-disciplinary team of 13 Participants representing 7 European countries has been formulated.