RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'New stability testing method to predict the performance of amorphous formulations' (AMORPHORM) under Horizon 2020.

assistant: **Objectives**

The importance of amorphous water-soluble substances has been increasingly recognized over last two decades in the pharmaceutical and food industries. Amorphous solids of small molecules offer a solubility advantage over their crystalline counterparts. Parallel to that, large molecular systems, such as proteins and enzymes, are difficult to crystallize but are often stabilized in amorphous formulations.Amorphous systems are inherently unstable and hence more prone to physico-chemical changes. In order to increase the safety and reduce the risk of their usage for both human patients/customers and industry it is necessary to determine their long-term physico-chemical stability.There is currently no existing reliable and widely applicable method for stability testing of amorphous formulations. During my research I have demonstrated such a method can be based on a terahertz spectroscopy, which probes the mobility of molecules when they are solids. I found that this approach is universal and should be able to be applied for all hydrogen bonding solids, which spans almost all organic compounds.The objectives of the proposal can be split into 3 blocks. The technology block will focus on developing terahertz spectroscopy into a reliable stability testing method to industrial standards and to explore whether more affordable instrumentation can be deployed alternatively to reduce the capital cost of the method.  In the pharmaceutical block we will aim to determine how pharmaceutical formulation and processing steps can be optimised for amorphous stability. We will examine also critical storage conditions for the amorphous products and how to prevent any recrystallization during their dissolution.In the food and biotechnology block we will aim to transfer the methods developed for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Authentication and Authorisation for Entrusted Unions' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The aim of the AU2EU project is to implement and demonstrate in a real-life environment an integrated eAuthentication and eAuthorization framework to enable trusted collaborations and delivery of services across different organizational/governmental jurisdictions. Consequently, the project aims at fostering the adoption of security and privacy-by-design technologies in European and global markets. This objective will be achieved by:1)\tdesigning a joint eAuthentication and eAuthorization framework for cross-domain and jurisdictional collaborations, supporting different identity/attribute providers and organizational policie,s and guaranteeing privacy, security and trust;2)\tadvancing the state-of-the-art by extending the joint eAuthentication and eAuthorization framework with assurance of claims, trust indicators, policy enforcement mechanisms and processing under encryption techniques to address specific security and confidentiality requirements of large distributed infrastructures;3)\timplementing the joint eAuthentication and eAuthorization framework as a part of the platform that supports collaborative secure distributed storage, secure data processing and management in the cloud and offline scenarios;4)\tdeploying the designed framework and platform in two pilots on bio-security incident management and collaborative services in Australia and on eHealth and Ambient Assisted Living in Europe; and5)\tvalidating the practical aspects of the developed platform such as scalability, efficiency, maturity and usability.The aforementioned activities will contribute to the increased trust, security and privacy, which in turn shall lead to the increased adoption of (cloud-based) critical infrastructures and collaborative delivery of services dealing with sensitive data. AU2EU
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New media consumption in Extended interactive TeleVision environment' (NEXTV), addressing dissemination and exploitation.

assistant: **Impact**

Conventional media consumption mostly takes place in a broadcast fashion (magazines, television etc.) and the business models associated with it are well practiced. The web has introduced an interactive form of consumption that necessitates totally new business models that are beginning to be mature. It is inevitable that broadcasting industry will augment today's ways of consuming content, e.g. by adding navigation support, storage, etc.For the above-mentioned reasons the purpose of the project is two-fold:1) Carry out studies on the additional business models that will be made possible by the proposed extensions to the broadcast scenario, as mentioned above.2) Develop an experimental set up to create the services and consume them on a consumer platform and verify the business models they should support.Objectives:The project aims at:- carrying out studies on new business models for interactive digital television made possible by new multimedia technologies;- producing technical specification for an end-to-end system integrating the technologies needed by the above business models (e.g. MPEG-2, HTML, MPEG-4, XML, etc.);- contributing this specification to international initiatives (MPEG, IETF, DVB, W3C, Web3D, AIC-I);- developing and extending software for the creation, delivery and consumption of the new interactive services;- creating applications demonstrating the new services and validating the tools;- validating the overall results of the project through an end-to-end experimental set up.Work description:The project will undergo a first phase of analysis and specification of business models, where the different actors of the interactive television business and their relationships will be identified. Their requirements will be studied, and according to them, at lea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Signal integration and rewiring during tumor development' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Cell fate decisions rely on signaling pathways that integrate external signals to coordinate specific intracellular programs. One of these pathways leads to the activation of p38α MAPK, which plays key roles in cell responses to many types of stresses as well as chemotherapeutic agents and oncogenes. Importantly, p38α acts in a cell context-specific and cell type-specific manner to integrate signals that affect cell proliferation, differentiation and survival. Evidence from mouse models and human cell lines indicates that p38α can negatively regulate tumor initiation at different levels. Intriguingly, recent results suggest that p38α activation may also sometimes have pro-tumorigenic functions. The molecular basis for the different functions of p38α are not well understood but it is likely that the network of substrates phosphorylated by p38α plays a major role. This project proposes to investigate molecular mechanisms of p38 MAPK signaling during tumorigenesis including the systematic identification of substrates and how they contribute to the different functions of this pathway. An important part of the studies will focus on the mechanisms underlying the rewiring of p38α signaling to serve pro-tumorigenic functions, including in-depth characterization of how p38α regulates the survival, proliferation and spreading of cancer cells, as well as its role in the interplay between cancer cells and stromal cells. We also plan to investigate the implication of p38α in tumor progression in vivo, using both xenografts and genetically modified mice that we have generated to either inactivate or hyperactivate the p38 MAPK pathway. These models will allow us to analyze the role of this signaling pathway in the regulation of tumor initiation, growth and spreading in different tissu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'HIV/SIV exploits DCs in mucosal infection: mechanisms of transmission and modulation by semen associated factors' (DCmucoHIV), addressing dissemination and exploitation.

assistant: **Impact**

Worldwide a large proportion of all new cases of HIV-1 infection are due to anal sexual intercourse, being the anal/rectal as well as distal colonic mucosa a site of viral uptake and entry. I recently demonstrated that intestinal lamina propria resident DCs migrate towards and extend cellular processes between the tight junctions of columnar epithelium through a CCR5-dependent mechanism, take up R5 but not X4 HIV-1, and then transfer infection to susceptible T cells. Although in mice CX3CR1+DCs are deputed to shuttle microbial antigens, there is no clear idea on which subsets of DCs are located in the human GI tract, are involved in HIV infection and contribute to virus spread, its presentation or possibly to its reservoir. Moreover, the ability of DCs to shuttle the virus across the mucosa may be largely modulated by components of semen, the natural vehicle of HIV during sexual transmission.To fill these gaps I propose a comparative study in macaques and humans using a multidisciplinary approach, which will unravel the mechanism associated with rectal transmission of HIV/SIV by DCs and their modulation by semen. Specific objectives will be:1. Define the subsets of DCs and the molecular mechanism(s) through which DCs directly sample HIV-1/SIV through the intestinal epithelium and facilitate the spread of the infection.2. Define the impact of semen on HIV/SIV-induced DCs migration across the epithelium.3. Determine the ability of lamina propria DCs subsets to migrate across the intestinal epithelium and to redistribute to draining lymph-nodes following in vivo exposure of Cynomolgus macaques to infectious pathogenic SIV.We expect to characterize the early events of DC-mediated intestinal transmission of HIV/SIV and thus contribute to the knowledge base needed to identify
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European collaboration to establish a case-control dna collection for studying the genetic basis of adverse drug reactions (EUDRAGENE)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Adverse drug reactions (Adds) are important causes of morbidity and mortality, and are under strong genetic influence. Identifying genetic variants that influence susceptibility to Adds has obvious practical applications, and will contribute to understanding of the molecular basis of adverse drug reactions. Research in this area is hampered by the lack of a resource in which to study genetic determinants of susceptibility to Adds. As most adverse reactions are rare, a case-control study is the only feasible design in which to study genetic associations. To obtain adequate numbers of cases of each of the Adds under study, a multicoated European collaboration is necessary as no single country will generate enough cases of any given ADR within a reasonable time. We propose to establish a freely shared resource consisting of clinical data and DNA samples from cases of Adds, together with a control group.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Channel Modelling and Advanced Signal Processing for Wireless Communication Systems' (CHASP).

assistant: **Concept**

The main objective of this proposal is to offer Dr. Serdar an opportunity to capitalise in Izmir Institute of Technology (Izmir Yuksek Teknoloji Enstitusu - IYTE), Izmir, Turkey, on the academic and professional research experience that he has acquired in the United States where has stayed more than 10 years.The project, Channel Modelling and Advanced Signal Processing for Wireless Communication Systems (CHASP), aims to study the indoor-to-indoor and outdoor-to-indoor wireless channel models, and aims t o propose several diversity based advanced signal processing algorithms based on the channel models developed for several different wireless communication platforms and systems, such as but would not be limited to, wireless local area networks (WLANs), digital television receivers (DTVs), Multi-Input Multi-Output (MIMO) communication systems.It is aimed at reversing and cancelling the effects of the European brain drain to third countries by employing doctoral students in the project. The topical coverage o f the research topic also allows the development of lasting co-operation with the scientific and industrial milieu of Europe and the USA. Further specific objectives addressed are: Benefit to the career of the researcher from the period of re-integration and potential for long term professional integration and job stability of the researcher; capacity to transfer acquired knowledge and develop lasting co-operation with the Europe and the USA; contribution to European scientific excellence and European competitiveness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Gas Sensors on Flexible Substrates for Wireless Applications', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The FlexSMELL concept is to realize a hybrid (organic-inorganic) very low-cost, ultra low-power olfaction system based on bio-receptor and implemented on a flexible substrate. Such a system is to be compatible with wireless read-out, setting the ground for the future development of smart sensing RFID tags. The FlexSMELL technology platform will be in principle suitable for different applications with the main ones envisaged for the in the field of logistics for the monitoring of perishable goods along their transport and storing, though smart packaging solutions. Teaching and training strategies will be implemented to prepare the next generation of scientists in this fast developing strategic research area. Eventually this effort will leverage the strength of the EU in organic electronics and micro-technologies for sensing applications as well as their integration into systems providing services to the individuals and to the community in the areas of food control though smart packaging, but also health, environment, communication and security.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Relevance and cognition for self-awareness in a content-centric Internet' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

RECOGNITION will develop a radically new approach for embedding self-awareness in ICT systems. This will be based on the cognitive processes that the human species exhibits for self-awareness, seeking to exploit the fact that humans are ultimately the fundamental basis for high performance autonomic processes. This is due to the cognitive ability of the brain to efficiently assert relevance (or irrelevance), extract knowledge and take appropriate decisions, when faced with partial information and disparate stimuli. Using the psychological and cognitive sciences as concrete inspiration, our approach is to develop functional models of the core cognitive processes that allow humans to assert relevance and achieve knowledge from information. This involves mechanisms such as inference, belief, similarity and trust. These will be translated to the ICT domain by development of flexible RECOGNITION algorithms that can be imbedded in ICT on a flexible basis for self-awareness.We will demonstrate this new paradigm for Internet content. The future Internet will see ever-increasing amounts of content that needs to be effectively managed and acquired, often from portable devices and in diverse spatial and social situations. The massive scale of content will swamp the user with information, impeding effective management and relevant acquisition by the user. By exploiting the self-awareness capability we will enable the users, content and network to cope effectively in a scalable manner, thus making unprecedented amounts of relevant content available and unleashing new classes of applications that extract maximum utility from content.<br/>
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Influence of parvalbumin neurons from the medial setum and diagonal band complex on medial entorhinal cortex activity' under Seventh Framework.

assistant: **Concept**

Cognition and memory result from communication between specific populations of neurons in our brains. In the medial entorhinal cortex (MEC), representations of location that are crucial for spatial cognition and memory are generated by neurons called grid cells. The rate at which these neurons fire action potentials can be decoded into fields that form a hexagonal grid spanning the environment.  In addition to the action potential rate, the information about spatial location is also encoded by the timing of action potentials relative to the phase of local theta frequency oscillations in network activity. The action potential rate and timing codes require synaptic input from a subcortical structure called the medial septum and diagonal band complex (MS-DB). Yet, we know very little about how projections from the MS-DB influence neurons in the MEC. I propose to establish principles whereby a major subtype of MS-DB neurons, which express the inhibitory neurotransmitter GABA, influence activity of neurons in the MEC.  I will combine optogenetic tools, to selectively activate GABAergic inputs from the MS-DB, with state of the art in vitro and in vivo electrophysiological recordings to identify and characterize their targets in the MEC. My approach will include the use of a new multi electrode array recording method that I will transfer to Europe, which will allow me to identify targets of MS-DB GABAergic neurons by simultaneously sampling large populations of neurons in the MEC. During my PhD I was the first to publish this method, which is currently not utilized in Europe. The proposal will advance the understanding of cellular and circuit mechanisms for spatial cognition and memory. It will also contribute to identification of design principles for biologically based compu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'PUZZLE_DIE: an innovative solution for a faster and cheaper car weight reduction to help carmakers to meet European limits to CO2 emissions.'.

assistant: **Innovation**

Meeting the new EU CO2 emission limits is imperative for automakers: otherwise the sanctions would be unbearable. Automakers have several options they can pursue in parallel. One of these is to achieve weight reduction, mainly by replacing steel with equally resistant but lighter weight materials and Aluminium is one of the leading materials. However, replacement comes at a cost that the end market does not recognize and it is this cost that drives manufacturers choices.Our project aims to reduce the current costs of production of components in Aluminium through the engineering of a new technique for construction of the dies, a technique which will revolutionize the world of aluminium die-casting (95% of all automotive parts in Aluminium are produced by the hot die-casting process), making it the competitive material to replace steel. In the mid-term, automakers will be able to intensify the use of aluminium as a replacement for steel and do so faster and more cheaply than afforded by other light materials, accelerating the process of weight reduction of the vehicle.