RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Principles of Protein Group Modification by the SUMO Pathway' (SUMOGROUP).

assistant: **Concept**

Posttranslational modification (PTM) of proteins by ubiquitin family proteins is of fundamental importance for cellular function, regulation and development. Ubiquitylation typically targets individual proteins, and high selectivity is achieved by a plethora of ubiquitin-conjugating enzymes and ligases. Much less is known regarding how modification by the ubiquitin-related protein SUMO influences the function of substrates and how specificity is provided. Surprisingly, although SUMOylation affects roughly 10% of all yeast proteins, only very few enzymes participate in the pathway. Moreover, although SUMOylation is essential for viability, mutants defective in SUMOylation of individual substrates usually lack deleterious phenotypes. We recently solved this puzzle as we found that SUMOylation frequently targets protein groups (“protein group modification”) rather than individual substrates; single modifications are often redundant or additive as SUMO functions as intermolecular “glue”, thereby stabilizing protein complexes. Hence, the traditional view that a single PTM on a given protein mediates a specific function does not seem to apply for many SUMO modifications.Entirely divergent from previous approaches we will thus focus for the first time specifically on protein group SUMOylation and its special requirements for specificity, induction and termination. Initially found for proteins of homologous recombination and nucleotide excision DNA repair, we will expand the concept of protein group SUMOylation with a focus on pathways relevant for cellular regulation and which are of medical importance. We will define the substrate repertoire of SUMO ligases, characterize their substrate targeting properties, and design novel tools aimed to address the function of protein grou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'MAGNONIC ARTIFICIAL NEURAL NETWORKS AND GATE ARRAYS'.

assistant: **Objectives**

We seek to explore and challenge the limits of spin-based devices and their energy efficiency. This will be achieved by combining two inherently energy-efficient technology paradigms: (i) magnonics (using spin waves – low energy magnetic excitations – to process signals and data) and (ii) neuromorphic computing (using large-scale integrated systems and analog circuits to solve data-driven problems in a brain-like manner). We will use nanoscale chiral magnonic resonators as building blocks of artificial neural networks. The power of the networks will be demonstrated by creating magnonics versions of field programmable gate arrays, reservoir computers, and recurrent neural networks. The ultimate efficiency of the devices will be achieved by (a) maximising their magnetic nonlinearity; (b) using epitaxial yttrium iron garnet, which has the lowest known magnetic damping, for thin film magnonic media and resonators; and (c) using wireless delivery of power. Sensitive to the resonators’ micromagnetic states, such artificial neural networks will be conveniently programmable and trainable within existing paradigms of magnetic data storage. The latter includes magnetic random-access memory (MRAM), which is already compatible with CMOS, while compatibility with other technology paradigms of spintronics will also be sought, explored, and exploited. Thereby, the key ambition of our proposed very forward-looking research programme is to develop and establish a novel, revolutionary class of energy-efficient spin-based components and devices for use in green high-tech data communication, processing, and storage technologies, thereby helping unlock the full potential of spintronics. We will seek dissemination of our developed and appropriately protected designs, processes, and technolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Human cardiac microtissues for studying lamin cardiomyopathy' (ACCURACY).

assistant: **Concept**

Lamin A/C cardiomyopathy (LMNA-CM) is a rare genetic disorder caused by mutations in the nuclear lamin gene LMNA. Affected patients typically exhibit dilated cardiomyopathy and reduced life expectancy, due to sudden cardiac death or accelerated functional decay requiring the heart transplant. Intriguingly, carriers of the same LMNA mutation show a wide spectrum of genotype-phenotype discrepancy, however a clear mechanistical understanding remains elusive. Recently, the host laboratory has developed an innovative multicellular three-dimensional (3D) human induced pluripotent stem cells (hiPSC)-cardiac microtissue (MT) model where hiPSC-derived cardiomyocytes display post-natal maturation allowing more faithful investigation of normal and pathological cardiac physiology. I will leverage this model and combine it with my strong background in molecular and cellular cardiology to advance the understanding of LMNA-related pathologies. Specifically, I will use patient-derived hiPSC from two family members with a severe and less severe form of LMNA-CM and their isogenic controls to generate 3D MT models. Next,  I plan to 1) characterize structural and functional properties and the transcriptome profile of multicellular LMNA MT models and their controls, 2) investigate cell-cell (cardiomyocytes, endothelial cells, cardiac fibroblasts and macrophages) interactions relevant to the disease development and progression, and 3) correct the identified molecular targets by pharmacological treatment or by CRISPR-mediated gene editing. The scientific, industrial and economic community will profit from this project twofold. First, I will establish a cost-effective model that provides better understanding of LMNA-CM pathogenesis, avoids cross-species variability and reduces the need for ani
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'VADO LIGURE COAL REBURN DEMONSTRATION PROJECT' under Fourth Framework.

assistant: **Concept**

The aim of the project is to demonstrate the reburn technology using coal as reburn fuel as a means of achieving NOx reductions from large, coal, wall-fired, power station boilers, of the type which provide the bulk of coal fired generation in Europe. The demonstration will be conducted on a 320 MWe opposite wall-fired boiler, unit 4 of Vado Ligure power station (ENEL, Savona), and will complement the knowledge gained from the Longannet Project. Due to the fact that most of the partners of this project are the same as for Longannet, the two projects will have a strong synergy, allowing a group of European companies to have a detailed knowledge of the reburning technology in all its aspects, greatly improving their competitiveness in the world market. Using the technology developed in this demonstration, a consortium of European Partners will be formed to exploit the growing requirement for this technology in the world market.In a coal fired boiler NOx is generated from high temperature processes which oxidise the nitrogen arising from fuel bound sources and from the combustion air. The reburn process is a fuel-staged process whereby three conceptual zones are created within the boiler. Approximately 80% of the original coal load is fired in the primary zone under near stoichiometric conditions. Coal is then injected above the primary combustion zone to provide the balance of the thermal input to the boiler. A fuel rich reburning zone is formed where NO is chemically reduced to molecular nitrogen. A burnout zone is achieved by introducing additional air further downstream to ensure complete combustion.Coal reburning requires supply of the reburn fuels to the boiler through a system of pipework and valves. The system allows the addition of recirculated flue gas to increas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The politics of aspiring sovereignty: Understanding separatist politics from a performative perspective' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Existing analytical approaches are poorly equipped to make sense of political entities that aspire sovereign statehood and present themselves accordingly, but which lack a recognised status. The prevalent scholarship struggles to categorize sovereignty-aspiring entities.This project departs from the extant literature in that it places the unsettled nature of sovereignty-aspiring entities – their defiance of categories – at the heart of the equation. Rather than resolving the interpretative “to be of not to be” dilemmas around their status and activities, the inherent contingency of separatist politics becomes our central vantage point. Turning to political performativity and aesthetics, the project seeks to determine how the performative repertoires of sovereignty-aspiring entities create democratic political space to bend or break the bounds of the formal institutional landscape.The project centres on three case contexts, which are highly rich and highly diverse: the Catalonian independence movement, the autonomous administration of Rojava (Syria) and the Tamil nationalist movement in Sri Lanka. It takes an inductive approach to then corroborate our findings within and beyond these cases. The project is structured around four inter-connected work packages each with its own research question and method. 1) We will use political ethnography to establish what political repertoires sovereignty-aspiring entities use. 2) We will use qualitative content analysis and art-based methods to assess the aesthetic dimensions of these repertoires. 3) We will use focus-group workshops to establish constituencies' understandings of these repertoires. 4) We will build a database of separatist political repertoires around the globe to validate our findings.The project’s overall objective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Glass, alchemy and medicine. Evidences of domestic practices in the capital of the Andalusi Caliphate' under Horizon Europe.

assistant: **Concept**

The study of material culture is one of the main tools for the past societies’ knowledge. Recently, new techniques, protocols and disciplines applied to traditional archaeological methodology have proved that glass played an important role in economic and social development through history. Regard to the Iberian Peninsula, works on archaeological glasses has focused on purely typological issues, above all from the Roman times, leaving aside other later historical periods. As part of our cultural heritage, the study of glass in al-Andalus can help to understand aspects and practices of Andalusian societies. For this reason, the project ‘Glass, alchemy and medicine. Evidences of domestic practices in the capital of the Andalusian Caliphate’ (GALENE) is proposed, which main objective is to establish the classification of glass for cosmetic and medicinal uses in domestic contexts of this period. This project proposes the study of an important set of glasses from Cordoba (Spain) by combining different skills and multidisciplinary approaches (traditional studies, experimental archaeology and the chemical analysis of materials) to determine for the first time the importance of glass in alchemy and medicine in Medieval times, the origin and manufacture of these vessels and objects, their evolution and whom used them, with especial attention to the female gender. GALENE will be conducted by Dr Velo at the Glass and Ceramics for the Arts (VICARTE) research unit of the Universidade Nova de Lisboa (Portugal), under the supervision of Prof Vilarigues. VICARTE is a research group of international relevance that combines different areas for the study of glass in antiquity and in the plastic arts. This centre has the facilities and technology necessary for the development of this proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Bringing the paradigm for marine pelagic production into the 21st century: incorporating mixotrophy into mainstream marine research' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The conceptual basis upon which management tools for our oceans, seas and coasts have operated are out-of-date. MixITiN will train an innovative team of early stage researchers (ESRs) to develop and deploy new methodologies for researching, monitoring and managing our marine environment according to the recently revised paradigm for marine pelagic production. Current management tools and policies operate within a paradigm that builds on a simple division functioning at the base of the food chain leading to fisheries, between ”plant-like” phytoplankton and their main consumers, the microzooplankton. Applicants of the research programme MixITiN have shown that this plant-animal paradigm represents at the least a gross simplification, if not a falsehood. The revised paradigm recognises that most phytoplankton and half the microzooplankton combine plant-like photosynthesis with animal-like consumer activity within the one cell. This form of nutrition, “mixotrophy”, supports the growth of organisms important for food chains and biogeochemical cycles removing atmospheric CO2; they are also causative agents of harmful algal blooms. In consequence of this revised paradigm, laboratory and field research approaches, management policies and allied computer modelling tools, are arguably no longer fit for purpose.  MixITiN brings together European world-class research and training centres from 9 different countries, with skillsets from molecular biology, physiology and computer modelling, to marine and coastal zone management, public and media engagement. MixITiN will train ESRs in multinational and multidisciplinary centres of excellence, with intersectoral engagement enabling them to gain employment in various sectors such as consultancy, government, academic, or allied industries
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Services for enhancing the innovation management capacity of SME’s  in the Spanish regions of Asturias, Cantabria, Castilla y León and Galicia', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This action shall provide specialized consulting services addressing innovation management capacity to SMEs which possess significant innovation activities. Beneficiaries of the SME instrument will receive support to enhance their nnovation management and advice within the geographicar area of Asturias, Galicia, Cantabria and Castilla y León.


**Keywords:** Kam, innovation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Two-dimensionally multiplexed on-demand quantum memories' (2DMultiMems) under Horizon Europe.

assistant: **Objectives**

A long-distance quantum network requires quantum repeaters dispersed between the end nodes. At intercity distances, the entangling rate of quantum repeaters may be limited by the photon travel time and the classical communication time. Quantum repeaters and memories based on rare-earth-doped crystals overcome this limitation, as the atomic frequency comb (AFC) protocol preparing these memories allows for temporal multiplexing. Besides temporal multiplexing, spatial and frequency multiplexing are also possibilities for rare-earth-doped crystals.Entanglement between these quantum memories is generated in a hybrid and heralded scheme by entangling each memory with a telecom photon and detecting a single photon after a beam splitter. Thus, the key element for quantum repeaters with rare-earth-doped crystals is the quantum correlations between the telecom photons and the memories.In this project, I will extend the storage capabilities and the entanglement generation rate of rare-earth-doped crystals such that realistic quantum repeater applications at intercity distances are within reach. The research project is divided into three research objectives: First, I will establish quantum correlations between a long-lived on-demand quantum memory and telecom photons. The correlations will be stored in spin waves for over milliseconds. Second, I will implement spatial multiplexing and store quantum correlations between telecom photons and 100 spatial modes of a single crystal. The spatial multiplexing is realized with acousto-optical devices in a crossed configuration. Third, I will entangle two on-demand quantum memories in 1700 modes with temporal and spatial multiplexing.I expect that spatial multiplexing will become a standard tool for solid-state crystal memories. Entanglement
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Study and development of a new technology for cooking fragile and expensive fruits, under pressure and with specific control and process management for a more effective production and to decrease important wastage' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The main goal of this project is to create the prototype of a new equipment with innovative heat treatment process under pressure and with control and process survey technologies . The study and creation of a prototype should be necessary and the SME proposers - manufacturers of special qualities of candied chestnuts and jams and derivated products for agro-industry - would be interested to contribute to this project and work with RTDs dedicated to study and specifications of a prototype able to solve the problems of breakage, time and energy consumption, conservation and wastage, control and automation for all types of fragile and expensive fruits, and then perforrn tests of the prototype and on selected products . The interest of such a research is to create a new heating process able to preserve the properties of specific fnuits, and determine substantial economies in speed and less wastage . The here after SMEs are specialised in complementary processes and have the same need to develop an ergonomic and efficient prototype to reach their goal . Considering both economical and technological aspects developing such a prototype is too much complicate and risky without the contribution of major RTDs .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sintering Regolith with Solar Light' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Future human activity on the lunar surface will use 3D printing to build infrastructure from lunar soil using the Sun as the only source of energy. Today this technology is considered disruptive; tomorrow it will be the standard. The RegoLight project will investigate the sintering process of lunar regolith simulants by means of concentrated sun light in order to prepare for future lunar missions for building infrastructure (leveled terrain, dust shelters, launch pads etc.) and structural components for lunar habitats.Solar sintering of regolith is currently at TRL3 , being able to build a regolith ‘brick’ in a laboratory set-up with a moving table in a solar furnace. RegoLight aims at enhancing this specific additive layer manufacturing technique –which seems very promising for lunar applications since it does not involve any consumables– by further characterizing the parameters for sintering different types of regolith and by developing a movable printing head capable both of pointing the concentrated solar beam at the required spot and of deploying incrementally additional layers of regolith in order to continue with the additive building process.Based on the mechanical properties of solar sintered regolith architectural scenarios and applications will be developed, taking into account the benefits of additive layer manufacturing and novel construction concepts for lunar gravity. This detailed Finite Element Modeling will provide a first insight into lunar architectural scenarios using this technology: With a concurrent engineering approach sample structures will be printed having been derived from ‘big picture’ scenarios and bottom up approaches at the same time.The project objective is the development of a regolith solar sintering device breadboard which will be va