RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'iBILD: Imaging Biomarker for Intelligent Lung Cancer Detection' to be submitted under Horizon 2020.

assistant: **Abstract**

Lung cancer is one of the most common cancers with the highest mortality rate both in Europe and Worldwide. In 2012, 449,000 new cases were diagnosed with 388,000 deaths recorded in Europe alone. The reason for the 86% mortality rate is that most lung cancers are detected only after clinical symptoms are prevalent, by which time the cancer is in a late stage. Early detection using Chest Computed Tomography (CT) can lead to markedly improved outcomes, as shown recently by the NLST lung cancer screening trial in USA which has achieved a ground-breaking, 20% mortality reduction. However there is currently no solution that allows screening and management of suspected lung cancer patients in an economically sustainable manner. Optellum has developed a novel technology, Deep Learnt Biomarker (DLB). It is a software application that will allow radiologist to make a more accurate diagnosis by providing additional information extracted from the same CT, already acquired anyway as standard of care. It is based on machine learning algorithms applied to large databases of CTs with known ground-truth diagnosis, which learns patterns not obvious to a human eye. Our product will a) improve early diagnosis of lung cancer, b) save EUR799M p.a. in unnecessary costs to EU health providers c) enable European Union to become the leader in lung cancer screening. Optellum was founded to commercialize machine learning technologies that will transform radiology by learning novel biomarkers from medical image databases. During this Phase 1 SME project, we will investigate the commercial feasibility of this first application and will develop a detailed business plan, with a focus on a roadmap to navigate the complex regulatory and health economics environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Health Effects of Indoor Pollutants: Integrating microbial, toxicological and epidemiological approaches' (HITEA) under Seventh Framework.

assistant: **Objectives**

Healthy housing and good indoor air quality are important goals of public health. However, biological indoor pollution due to dampness, moisture and mold is an emerging environmental health issue, as recognized in EU indoor air policy documents. Prevalence of dampness is remarkable, and may still increase due to demands of energy savings and extreme weather periods and floods associated with climate change. The exposure may lead to long-term impacts such as asthma. The documentation is strong on association between building mold and health, but the causative agents and disease mechanisms are largely unknown, which impedes recognition of a mold-affected patient in health care. Efficient control and regulation are hampered by the insufficient understanding of these causalities. Understanding of the links between building practices and health is lacking. There is an urgent need for European-wide knowledge to form a basis for establishing building-associated criteria for healthy indoor environments. The aim of this proposal is to clarify the health impacts of indoor exposures on children and adults by providing comprehensive exposure data on biological and chemical factors in European indoor environments, and by combining this information with extensive health data obtained from a field study and from existing population cohorts. Modern microbiological, toxicological and immunological techniques will be used that allow the revealing of the links between the harmful exposures and long term impacts on health, and the mechanisms behind. Data on determinants and distributions of indoor microbial agents will be provided for development of avoidance measures and other dissemination for stakeholders. The study networks experts on environmental epidemiology, microbiology, immunolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Geotechnical thematic network' under Fifth Framework.

assistant: **Concept**

Given the perspective of supply-oriented building specifications, codes and standards currently enforced in most countries inhibit building and construction trade. Performance Based Building (PeBBu) strives to overcome this problem and aims at enhancing consumer-orientation, cost-optimisation, product and process innovation, and the enforcement of international trade possibilities in construction. This is expected to reduce total construction costs (694 bill. ECU in the EU in 1999) by as much as 25% in the long term. The proposed network aims to stimulate and facilitate international programming, the coordination of research, and the implementation of results from research in the area of PeBBu. It will stimulate actual investments in such research and projects and will provide EU Networks members with optimal access to worldwide knowledge and experience in the area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Biomolecular structures elucidated by cOLD magic angle spinning NMR with dynamic nuclear polarization', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Magic angle spinning solid-state nuclear magnetic resonance (MAS-NMR) has proved to be an invaluable tool in the structural and dynamical characterization at atomic resolution of biomolecules that are not suitable for solution NMR or diffraction studies, notably amyloid fibrils. These proteinaceous aggregates are implicated as the cause of many neurodegenerative diseases, such as Huntington’s, Alzheimer’s, and Parkinson’s diseases. Due to severe sensitivity limitations and the difficulty in detecting long-distance contacts in uniformly 13C/15N labelled systems, the characterization of these fibrils has been carried out in-vitro using multiple expensive samples with specific isotopic labelling schemes. In addition, it has been demonstrated that fibrils can adopt various, environment-dependent structures, which result in different levels of toxicity.The global objective of this proposal is to develop a new approach for the structural characterization at atomic resolution of biomolecules, which will be compatible in a long-term vision with native in-situ samples, as for example fibrillar plaque obtained from brain tissue. This would be invaluable in understanding the mechanisms of fibril formation in neurodegenerative diseases. The concrete approach will rely on the use of samples at natural isotopic abundance studied with an emerging hyperpolarization technique ULT-MAS-DNP (Magic Angle Spinning Dynamic Nuclear Polarization at Ultra Low Temperature). The sensitivity of the commercially available MAS-DNP technique will be significantly improved by the combined use of a unique closed-loop He cryostat (allowing ULT) with high-spinning NMR probes. This will routinely afford the sensitivity required for 13C/15N 2D NMR measurements on natural isotopic abundance samples, includin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SUSTAINABLE ECOSYSTEM FOR THE ADOPTION, RAMP-UP AND TRANSFER OF EMERGING ELECTRONICS SOLUTIONS' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Despite significant recent progress made by the EU industry, the level of digitalisation of industry remains uneven, depending on the sector, country and company size. Facing at the same time a scattered landscape of Research, Industry and Institutional stakeholders, the efficient adoption and transformation of enabling technologies into business visions & concrete market cases remain limited. This slow diffusion of digital technologies poses a risk to the EU’s ability to compete in the global economy. This is particularly true for Organic Large Area Electronics (OLAE) enabling technologies whose industry made significant progress recently and has established itself as a competitive growth industry. Despite proving that more and more products have matured onto the global market, the actual diffusion and efficient adoption of OLAE technologies remain limited. Underlying reasons and key challenges are identified (cost, processes, encapsulation, scalability, yield, standards & regulations), for which major breakthroughs are needed on use, production and cost rather than on basic technology, which reflects the growing market orientation of OLAE. To address both market & technology specific challenges, SmartEEs2 will be key role to link technology promises with real use/business cases. These cases will be implemented through a unique digitalisation experience providing experimentation, testing or support to manufacturing. SmartEEs2 will capitalize upon SmartEEs’ strong technological OLAE platform and focuss on the uptake of Flexible & Wearable Electronics enabling use cases, where OLAE can valorize its uniqueness (flexibility, conformability) and its promises for solutions in the fast growing business of wearables and Internet of Everything. SmartEEs2 will orchestrate a pan-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ninth International Symposium on Tubular Structures' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The objectives of the symposium are to bring together young and senior international researchers. Engineers, Architects, steel fabricators and steel manufactures for exchange of information and training in the safe and economical planning, design and execution of tubular structures. Internationally renowned leading scientists are invited, most of whom will be in the international scientific committee. Particular attention will be paid to aesthetics and architectural use, whereby world-renowed architects will also be invited as keynote speakers to present successful projects. This will also encourage interaction with industry.The contents will include:Main topics such as architecture; applications, innovative structures; fabrication, assembly and erection; repair and rehabilitation of existing structures, fire resistance. Specialised topics such as static and fatigue behaviour of connections, concrete filled hollow sections, composite tubular structures; offshore structures; earthquake resistance; development of specifications and standards; expert systems and knowledge-based systems.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00049-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'ENVIROCITY TECHNOLOGY VALIDATION PROJECT'.

assistant: **Innovation**

InfoCity is the technology validation project of the ENVIROCITY pre-demonstrator" project, that delivers to the public city-information via telematics and the WWW. INFOCITY involves: up-scaling of the current ENVIROCITY technology and pre-demonstrator interface into a "demonstrator", operational on the Internet. Procedures will be developed, to ensure that the technology and information are adequately protected (IPR)."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'HLA-homozygous iPSC-cardiomyocytE Aggregate manufacturing technoLogies for allogenic cell therapy to the heart' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

HEAL will focus on general bottlenecks to induced pluripotent stem cell therapies with a particular focus on heart failure, which remains a major cause of morbidity and mortality with very few treatment options.HLA-homozygous cell line derived cardiomyocyte aggregates offer the prospect of a restorative heart therapy applicable to large patient populations and to overcome economic barriers associated with autologous approaches. By developing solutions for their mass-production and cryopreservation we will enable allogeneic treatment with minimum requirements for immunosuppression.Assays for assessment of immunogenicity will provide data for the development of an artificial intelligence powered algorithm to predict recipients's immune responses for personalised design of immunosuppression protocols.A potency assay to assure product effectiveness will be developed together with assays of tumorigenicity in vitro and in vivo that meet and exceed current regulatory requirements. A genetic integrity pipeline defining the most sensitive assays for rigorous assessment will be developed and a rescue tool in the form of a  biallelic suicide gene for programmed cell death will add to the safety toolbox for the  therapy.Optimisation of cell-product administration in terms of retention and engraftment, including catheter-based delivery as minimally invasive alternative to surgical application, and assessment of risks of graft-induced arrhythmia will be determined in a pig model. Early dialogues, via established links, to the regulatory authorities will ensure proper development according to GMP requirements.Freedom to operate and licensing strategies with a health technology and infrastructure assessment of European centres will set the scene for approval of the cell product and rel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A Holistic Data Privacy and Security by Design Platform-as-a-Service Framework Introducing Distributed Encrypted Persistence in Cloud-based Applications', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The vision of PaaSword is to maximize and fortify the trust of individual, professional and corporate customers to Cloud -enabled services and applications, to safeguard both corporate and personal sensitive data stored on Cloud infrastructures and Cloud-based storage services, and to accelerate the adoption of Cloud computing technologies and paradigm shift from the European industry. Thus, PaaSword will introduce a holistic data privacy and security by design framework enhanced by sophisticated context-aware policy access models and robust policy access, decision, enforcement and governance mechanisms, which will enable the implementation of secure and transparent Cloud-based applications and services that will maintain a fully distributed and totally encrypted data persistence layer, and, thus, will foster customers' data protection, integrity and confidentiality, even in the case wherein there is no control over the underlying third-party Cloud resources utilized.In particular, PaaSword intends not only to adopt the CSA Cloud security principles, but also to extend them by capitalizing on recent innovations on (a) distributed encryption and virtual database middleware technologies that introduce a scalable secure Cloud database abstraction layer combined with sophisticated distribution and encryption methods into the processing and querying of data stored in the Cloud; (b) context-aware access control that incorporate the dynamically changing contextual information into novel group policies implementing configurable context-based access control policies and context-dependent access rights to the stored data at various different levels; and (c) policy governance, modelling and annotation techniques that allows application developers to specify an appropriate level of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'EBIO-HUB: CHAIR OF RESEARCH CENTRE IN BIOMEDICAL ENGINEERING'.

assistant: **Concept**

The ambitious aim of the project is to establish eBio-hub- research centre in Biomedical Engineering within University „Politechnica” of Bucharest (UPB) leaded by Era Chair holder. The goal of the eBio-hub project is to unlock and foster excellent research in biomedical engineering, capitalizing the existing knowledge in UPB and integrating with local research and clinical expertise from University of Bucharest, Carol Davila University of Medicine and Pharmacy and local hospitals as well as making use of the newly created research infrastructure (INOVABIOMED) by setting up a strong research group and attracting top academics in the field, rising the competitiveness of UPB research in the European Research Area (ERA).  The developing of biomedical engineering - a discipline that applies engineering principles of design and analysis to biological systems and biomedical technologies- is in line with the Romanian National Strategy for R&D. The Chair and the eBio-hub centre will address the main barriers faced in UPB such as lack of institutional organization in linking UPB research teams with different expertise and linking the existing UPB research teams with other local research institution, lack of financing, and practice not in line with open recruitment policy. By establishing a Chair Holder with excellent research credentials and leadership competences, by creating a research team with broad expertise and wide network for collaboration, will greatly improve the research culture and research performance at UPB. Sustainability will be granted by research funding procurement for projects, structured cooperation with local or international industrial and public research and educational entities, establishment of a new study field in the doctoral programs at UPB, PhD summe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Lower application of insecticides by the production of insect resistant crops using novel protease inhibitor genes' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Losses of agricultural production due to pests and diseases have been estimated to 37% in Europe and world-wide. At present, crop protection relies predominantly on the use of agrochemicals. For the future, it is necessary to better safeguard the environment and to develop sustainable agricultural systems. Such systems will have decreased inputs of energy and chemicals, and will not generate harmful outputs such as pesticide residues. To achieve this objective, it is necessary to enhance the resistance of plants to pests and pathogens. Whilst some success has been achieved towards this aim using conventional plant breeding techniques, the new technology of plant genetic engineering offers the opportunity of introducing resistance genes from foreign species into crop plants, thus increasing the available gene pool. Several of these transgenic crops have already been brought from the US to European markets in 1996 and 1997. It is the aim of this proposal to develop within Europe similar products for the European farmers to increase their competitiveness by decreasing their needs to spray insecticides.  At present, the main strategy to develop insect resistant plants via genetic engineering is based on the use of Bacillus thuringiensis (Bt) toxin ge This has resulted in transgenic crops with high resistance against specific insects. To increase the spectrum of insects which can be controlled (Bt toxins have a narrow activity spectrum), it is necessary to also use other insecticidal genes, like protease inhibitor (Pl) genes. Transgenic crops, including rice, expressing foreign pis show reduced predation by their natural pests. It is now necessary to further develop protease inhibitors that are broadly active against all proteases that insects in nature use to overcome prote