RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Part distortion prediction, design for minimized distortion, additive manufactured polymer aerospace parts' (PADICTON).

assistant: **Concept**

PADICTON answers the scope of JTI-CS2-2018-CFP09-AIR-02-75 call on the topic “Design Against Distortion”. The high-level challenge PADICTON project will be addressing is to develop accurate and functional distortion prediction models for Additive Manufacturing of polymeric and composite parts that can be utilised in conjunction with other design tools to produce parts adjusted to account for distortion effect. The efforts will focus on Fused Filament Fabrication, with or without fibre reinforcement, and the selective laser sintering (SLS) process. The project will aim at developing a high-fidelity reference process simulation method for FFF and SLS for the materials of primary interest to the Topic Manager. In parallel, a rapid process simulation methodology will be sought. While the first method will encompass detailed consideration of coupled thermal-chemical-mechanical analysis for the determination of residual stress and distortion, the low fidelity model will be based on the “inherent strain” analysis method, backed with experimental characterisation and validation activities. State of the art AM equipment will be utilised with capability to alter the processing parameters and an innovative inline monitoring system will be realised to assess the produced part as it is being built. Once the analysis methods are in place the distortion prediction capabilities will be further utilised to enhance the part design by incorporating the risk of distortion. The traditional part optimisation tasks (shape or topology) will consider the risk of distortion as an extra parameter. These developments will be implemented in a seamless Computer Aided Engineering (CAE) environment, initially based on the existing CAE platform available to PADICTON consortium. At a next step, the capa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Homelessness as unfairness' (2014-2020).

assistant: **Innovation**

Empirically informing a European theory of justice is a complex and challenging endeavour, however the emergence of current social crisis, and the resulting inequalities and unfairness, bring about the need to revise the premises that facilitate translation of the theory into concrete guidance to effective social policies and coherent programs and practices.To respond to this challenge, a trans-disciplinary Consortium has been organized to provide a comprehensive series of empirical data, in different ecological levels, in order to understand differences in perceptions of inequality. Through a case study on an extreme expression of inequality and unfairness - LONG-TERM HOMELESSNESS – organized in a multi-method and convergent design, HOME_EU is focused on understanding: a) How much inequality do EU Citizens accept regarding Homelessness; b) How the people with a lived-experience of Homelessness (both present and past) perceive the opportunities, choices and capability gains with the services and the existing social policies; c)  What strategies consider the service providers to be more effective in reversing Homelessness; d) How social policies and policy key stakeholders contribute to effectively reverse Homelessness; and e) Develop a generalizable indicator (correlating the different ecological levels of analysis) based on the data gathered by each partner country on the key elements of policy and program efficacy.We believe that with this journey into an extreme situation, we are able to generate translational knowledge about the ecology of long-term Homelessness and contribute towards the advancement of an empirically based EU theory & practice of justice as fairness.


**Keywords:** Unfairness, Social Innovation, Long-Term Homelessness
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Restorative Plasticity At Corticostriatal Excitatory Synapses' to be submitted under Seventh Framework.

assistant: **Abstract**

Long-lasting, activity-dependent synaptic changes are thought to underlie the ability of the brain to translate experiences into memories and seem to represent the cellular model underlying learning and memory processes. Alteration of brain plasticity may lead to the motor and cognitive disturbances observed in neurodegenerative diseases. Therapeutic approaches targeting synaptic plasticity could prevent neuronal degeneration and restore altered motor and cognitive functions. Long-term synaptic plasticity, long-term potentiation and long-term depression, are widely expressed at excitatory synapses throughout the brain and have both been described at corticostriatal connections, at which they might underlie motor-skill learning, cognitive performance and reward mechanisms. Unique feature of corticostriatal plasticity is the observation that the loss of these opposite forms of synaptic plasticity has been observed in experimental models of neurodegenerative disorders such as Parkinson’s disease (PD). REPLACES will use cortical striatal plasticity and its alterations in experimental PD to explore basic mechanisms of brain plasticity and repair and to translate the new generated knowledge into novel restorative therapeutic approaches. The long-term efficacy of new treatments for PD will be conditioned by their ability to restore, structurally and functionally, the synaptic wiring of striatal neurons and physiological synaptic plasticity. REPLACES addresses the potential restorative effects of either novel pharmacological treatments or neuronal transplants on the corticostriatal microcircuitry. Since chronic treatment with DA precursor L-DOPA induces in the majority of PD patients a maladaptative plasticity causing dyskinesia, innovative strategies should prevent the develop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'PRE-SCREENINGDEVICE FOR SLEEP APNEA' (PREDESA) under Horizon 2020.

assistant: **Objectives**

Obstructive sleep apnea (OSA) is a common disease, affecting 2–7% of population, but many of them are still undiagnosed. Nukute has developed a novel and cost effective technology to pre-screen and assist in treatment of OSA patients. Innovation utilizes noise (respiratory rate and profile) and acceleration of chest and diaphragm (respiratory motion) first time as biomarkers of OSA. In the pre-screening device a stereo microphone measures the ambient and respiratory sounds, and an accelerometer measures the motion of neck muscles. In addition to these components, the diagnostic device has also two more accelerators and a blood oxygen level measurement. In both cases, the data is wirelessly sent to the mobile phone application. If the device includes the treatment feature, an electrical stimulation prompts the user to adjust sleeping position for increased airflow, when apnea occurs. The first prototype of the device achieved a proof of the concept in the preclinical tests in the beginning of 2015 and the results were very good. The main benefits of this system compared to existing pre-screening and diagnostic devices are easiness to use, cheapness (70-90% cheaper than competitors), accuracy and comfort wireless design. The device has two main product lines: OSA diagnostic and treatment assistance device for professional use and OSA pre-screening and treatment assistance device for consumers. In a first stage, the target market of diagnostic device is Finnish hospitals and that of pre-screening device is consumers in the US. The device has potential to generate big societal savings in Europe and worldwide by offering cost-effective and easy way to pre-screen OSA. The main activities of this project are: creation of patent family in the US, creation of quality management
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The detection of boundary changes as a method for early diagnosis of cardiovascular disease', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Current clinically approved methods for detection of Cardiovascular Disease have a number of associated disadvantages and limitations. All methods have some reliability issues and most are based on detection of plaque. Once plaque already exists however, disease may have been getting progressively worse for decades. Methods based on detection of plaque are therefore not able to detect the disease in the early stages. Better diagnostic methods, especially for early detection, are therefore urgently needed and will provide a great improvement on existing methods. A major problem in establishing better diagnostic methods is the large scientific gap which exists between clinicians and scientists, making communication extremely difficult. This proposal will use the unique skill-set of Russian scientist with formidable clinical knowledge and the highest level of mathematical and computational skills to transfer clinical knowledge to the scientific community. This proposal will use this unique skill-set to establish the necessary scientific basis to pursue new methods to detect cardiovascular disease earlier and more reliably than presently possible. The essence of the approach is that material changes must occur at the inner boundary of the artery in the very earliest stages of disease. This novel approach will use advanced asymptotic long wave methods developed by the UK host and will determine changes at the inner boundary through changes to the expected dispersion spectrum. The results from this project will provide the urgently required framework to supply a scientific benchmark, enabling new diagnostic equipment to be developed; this will not only save and improve quality of life, it will significantly reduce the financial cost of treatment and long term care of cardiova
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'In vivo gut-brain optogenetic endomicroscopy  for digestive disorders management'.

assistant: **Objectives**

Proper functioning of the digestive system depends largely on the enteric nervous system (the gut’s brain), which on one side is linked to the gut’s microbiota and on the other side is linked to environmental factors, like stress, via gut-brain axis. Communication along this axis is not very well understood, even though it is crucial for the diagnosis and treatment of functional digestive disorders, which are the most common problems in the digestive system imposing a significant burden on public health. One of the limiting factors is the lack of tools enabling investigation of gut’s neuronal network in vivo.The goal of this proposal is to provide an insight into the functioning of microbiota-gut-brain axis in vivo. We will develop a novel optogenetic endomicroscope based on Optical Coherence Tomography (OCT) capable of mapping the morphology and the functionality of the enteric nervous system and microbiota sampling. We hypothesize that such tool, in addition to direct analysis of the gut status in various digestive conditions, can also be indirectly used to stimulate the brain response via gut-brain axis. To test our hypothesis, we will co-register performance of the proposed method with functional magnetic resonance imaging to investigate in animal models 1) the response of the brain to activation of serotonin neurons in the gut and 2) the response of the gut to optogenetically induced depression at the brain level. Any tool improving understanding of interactions between microbiota, gut and brain would be of paramount importance for improving management of many patients with digestive disorders. Moreover, such information has potential to introduce novel diagnosis and treatment paradigm in obesity, and other diseases like Parkinson disease or Alzheimer disease. With
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'When Public Health Campaigns Warn You, but Your Friends Like to Drink – Connecting Computational Social Science and Neuroscience to Understand Real-World Health Behavior' (TheRealCompetition) under Horizon 2020.

assistant: **Objectives**

Malleable unhealthy behaviors excessively burden global societies. Public health media campaigns could offer cost-effective, large-scale interventions, but affect behavior only minimally. To date, health campaigns are optimized to outperform alternative health campaigns in their effects on behavior (e.g. comparing gain to loss-framed messages). Yet, in real life campaigns face other competitors like campaign-related media and peer-produced content. These sources are amplified by popular social media and thus often presented in close proximity to health campaigns. Each source may favor healthy or unhealthy viewpoints, causing health campaign-consistent or -contradictory updates to an individual’s evaluation of a behavior. Ignoring real-world competitors of public health campaigns is a grave oversight that can reduce or even reverse campaign effects on behavior. I seek to understand and optimize public health campaigns in the context of TheRealCompetition, namely healthy and unhealthy media and peer content on social media. This is non-trivial. Self-reporting media exposure and psychological processes underlying media effects overburdens lay participants who struggle to recall and explain how they integrate multiple competing influences on their behavior. In a game-changing interdisciplinary approach, I connect computational social science and neuroimaging to objectively and unobtrusively quantify daily exposure to campaign-related social media content, and understand the neuropsychological processes that explain campaign effects in the context of other sources of influence. Results offer actionable recommendations for practitioners and ecologically validate basic decision-making models. This action brings my unique dual expertise in media effects and neuroscience to Euro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A cancer vaccine to boost body’s natural defences to fight chordoma and head and neck cancer' (MaxONCO).

assistant: **Concept**

MaxiVAX a private Swiss clinical-stage biotech company with a novel cancer immunotherapy product in development (MaxONCO) will perform Phase 2 clinical trial in Head & Neck indication and prepare the commercialization of MaxONCO, its first immuno-therapy product. The objective of the Phase II clinical trial is to demonstrate efficacy and safety of MaxONCO in the patients treated and compare the results to the current standard of care.MaxONCO is a biological product acting as a cancer vaccine and composed of (i) an immune boost agent released insitu by a genetically modified cell line and (ii) cancer autologous cells, which are the source of antigens. A Phase 1trial in 25 patients with a range of cancer types at an advanced stage showed encouraging efficacy data and a benignsafety profile of the treatment.Head and Neck cancer is a group of cancers that develops in the areas of the head and neck which include the mouth,throat and salivary glands; accounting for 650,000 new cases in 2018 diagnosed globally. With the approval ofSwissmedic, MaxiVAX has initiated the Phase 2 clinical trial to evaluate MaxONCO in 40-45 patients with Head& Neck cancer. The study will be conducted across 4-6 different sites in Switzerland. Encouraging clinical resultsshow that among 4 initial Head & Neck patients treated with MaxONCO all survived beyond the 6-month time point(primary efficacy end point).Currently accounting for 8 employees, the company plans to grow up to 25 employees by the end of the SME phase2 project, creating up to 30 indirect jobs.


**Keywords:** Orphan disease, cancer vaccine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A Searchable Internet Database of Seabed Samples from the Ocean Basins held at European Institutions' (1994-1998).

assistant: **Innovation**

This proposal addresses a fundamental problem relating to marine sample data management within Europe and, if implemented, will enable, and streamline, exploitation of an important, but currently underexploited, existing raw data resource.  We propose: 1. To establish a searchable central-access database of seabed sample data held at European Institutions accessible through the World Wide Web (WWW).  2. To establish a European Core Curators Group to update the database, both in content and design, standardise core description protocols throughout Europe, solicit end-user needs in accessing seabed data, and represent European marine curatorial facilities at an international level.  Within the countries of the European Union many thousands of marine cores and seafloor samples have been collected by research institutes, universities, and exploration and survey companies. These sediment cores and samples have a wide range of applications and are the fundamental data source for information on seabed character and recent sedimentation. Such information is vital to a large number of end-users in industry, governments and academia. Research into global climate change, slope stability, oil exploration, pollution assessment and control, surveying for laying telecommunication cables and offshore pipelines, coastal development and the siting of seafloor structures by government and commercial concerns all rely on data obtained from marine sediment samples. The collection and storage of these samples represents a considerable financial outlay and even a conservative estimate would put the total cost of collecting and storing these samples at several hundred million ecu. It is currently very difficult for end-users of seabed data to find out what seafloor samples have been collected
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PaN-data Europe Strategic Working Group' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The PaN-data Europe Strategic Working Group (PaN-data Europe) will support the development of a sustainable data infrastructure for European Neutron and Photon laboratories. The existing PaN-data collaboration aims to develop a common data infrastructure for European Neutron and Photon large facilities. The PaN-data Europe Support Action will support the integration of this work with the creation of a fully integrated pan-European e-infrastructure supporting all scientific communities.PaN-data Europe brings together eleven large multidisciplinary Research Infrastructures. The consortium operates hundreds of instruments used by over 30,000 scientists each year. They support fields as varied as physics, chemistry, biology, material sciences, energy technology, environmental science, medical technology and cultural heritage. Applications are numerous, e.g. crystallography reveals the structures of viruses and proteins important for the development of new drugs; neutron scattering identifies stresses within engineering components such as turbine blades, and tomography can image microscopic details of the 3D-structure of the brain. Industrial applications include pharmaceuticals, petrochemicals and microelectronics.This Support Action focuses on 5 standardisation activities:1. development of a common data policy framework2. agreement on protocols for shared user information exchange3. definition of standards for common scientific data formats4. strategy for the interoperation of data analysis software enabling the most appropriate software to be used independently of where the data is collected, and5. integration and cross-linking of research outputs completing the lifecycle of research, linking all information underpinning publications, and supporting the long-term preserva