RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dual carousel semi automatic reticle stocker' (RETIMATIC).

assistant: **Innovation**

- To demonstrate under real manufacturing conditions the productivity and cost of ownership benefits of this fast reticle retrieval (10 secs) and dense (1000 reticles in 1.5 m{2} footprint) ASIC reticle storage machine.- To show satisfactory operation of the stocker supervising computer when linked to the fab CIM system.The performance of the dual carousel semi-automatic reticle stocker developed by Dynamic Microsystems is to be assessed and improved. Multiple reticle changes and high number of reticles in use typify the ASIC business, which seeks to improve the problem in manageable proportions with this reticle cassette stocker.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of an in-line multi-parameter oil condition monitoring system including a novel oil corrosion sensor for bio-gas operated power generator engines' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

We will+ develop an integrated sensor system for in-line oil condition monitoring covering the most important oil condition parameters including corrosion (acidity) for industrial power generator engines or turbines;+ develop a novel sensor for the online measurement of corrosion effect as a direct indicator for the acidity of the engine oil which is a critical parameter in case of bio-fuel operated combustion engines;+ be able to ensure the protection of the machine by online monitoring, while allows the optimization of the oil change interval, leading to reduced maintenance costs in the long-term, especially in case of large oil fillings.The partners have a clear and proven technological concept for the development of the novel corrosion (acidity) sensor as well as the cooperation with leading oil sensor producer enables an in-depth insight to current market needs. The research on the novel corrosion sensor has started already 8 years ago, reaching by now a technological level allowing the step towards a commertial product.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Bio-Imaging of Zoonotic and Emerging Bunyaviruses'.

assistant: **Innovation**

We aim to understand host cell entry of enveloped viruses at molecular level. A crucial step in this process is when the viral membrane fuses with the cell membrane. Similarly to cell–cell fusion, this step is mediated by fusion proteins (classes I–III). Several medically important viruses, notably dengue and many bunyaviruses, harbour a class II fusion protein. Class II fusion protein structures have been solved in pre- and post-fusion conformation and in some cases different factors promoting fusion have been determined. However, questions about the most important steps of this key process remain unanswered. I will focus on the entry mechanism of bunyaviruses by using cutting-edge, high spatial and temporal resolution bio-imaging techniques. These viruses have been chosen as a model system to maximise the significance of the project: they form an emerging viral threat to humans and animals, no approved vaccines or antivirals exist for human use and they are less studied than other class II fusion protein systems. Cryo-electron microscopy and tomography will be used to solve high-resolution structures (up to ~3 Å) of viruses, in addition to virus–receptor and virus–membrane complexes. Advanced fluorescence microscopy techniques will be used to probe the dynamics of virus entry and fusion in vivo and in vitro. Deciphering key steps in virus entry is expected to contribute to rational vaccine and drug design. During this project I aim to establish a world-class laboratory in structural and cellular biology of emerging viruses. The project greatly benefits from our unique biosafety level 3 laboratory offering advanced bio-imaging techniques. Furthermore it will also pave way for similar projects on other infectious viruses. Finally the novel computational image processing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Immune regulation of NF-kappaB in Dendritic Cell subsets by the ubiquitin editing enzyme A20' (2007-2013).

assistant: **Innovation**

Dendritic cells (DCs) are strategically positioned as sentinels that process antigens and present these to other immune cells, thereby acting as crucial messengers between innate and adaptive immunity. DCs are activated by various receptors, including Toll-like receptors (TLRs) that recognize microbial products. TLR stimulation leads to activation of the transcription factor NF-κB, which is the key regulator of pro-inflammatory genes. NF-κB activation is tightly regulated by ubiquitination, a modification process that targets proteins for proteasomal degradation. The most important negative regulator of NF-κB activation is the ubiquitin-modifying enzyme A20/Tnfaip3. We have recently established an in vivo constitutive NF-κB activation mouse model system by DC-specific A20 gene ablation (using the Cre/loxP system). Our preliminary results demonstrate that A20 in DCs critically controls inflammation in the context of allergy and autoimmunity. Consistent with defective termination of TLR/NF-κB signalling, we found that A20KO DCs manifest an activated phenotype and DC-A20KO mice exhibit increased inflammation and high levels of serum autoantibodies. Remarkably however, DC-A20KO mice are protected from allergic asthma and experimental autoimmune encephalomyelitis. The proposal will provide fundamental knowledge on the effects of NF-κB activation in different DC subsets and should offer a starting point for therapies for inflammatory diseases based on ubiquitin modification.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'BIONOTE– A CROWDSCIENCE PLATFORM FOR IDENTIFYING AND LEARNING ABOUT ALL SPECIES ON EARTH' in the context of a Horizon 2020 call.

assistant: **Objectives**

BIONOTE– A CROWDSCIENCE PLATFORM FOR IDENTIFYING AND LEARNING ABOUT ALL SPECIES ON EARTHMAJOR GOAL: To inspire and empower people to identify, document, explore and protect the world’s biodiversity. BioNote will advance Europe’s commitment to monitor and protect biodiversity, by greatly facilitating access to species identifications worldwide. It will simultaneously increase information on where species occur for research, education, citizens, government and industry. We share this planet with 7 million other species, many of which provide key services and goods for humans. But, the world's biodiversity is threatened today by urbanization and climate change. To protect the world's valuable biodiversity, citizen scientists need a way to easily identify species with their smartphones, and researchers need large datasets of species occurrences to build models. BioNote provides a platform the give both groups the tools they need. We will create the go-to software and data platform for species identification, collaboration and big data analysis, with our smartphone app and data portal. BioNote will provide an increase in knowledge about biodiversity; a massive input of new species observation records; facilitate access to biodiversity data needed for decisions on land use; provide ~20 jobs to university-educated individuals in the EU, and ~100 in tropical regions in the next 4 years; and drastically lower the cost of biodiversity research.BioNote has so far received initial funding from three different organizations who support and believe in BioNote's future, and formed an outstanding core team of scientists and experienced business people.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cerebellar circuit mechanisms of coordinated locomotion in mice' under Horizon 2020.

assistant: **Concept**

A remarkable aspect of motor control is our seemingly effortless ability to generate coordinated movements. How is activity within neural circuits orchestrated to allow us to engage in complex activities like gymnastics, riding a bike, or walking down the street while drinking a cup of coffee? The cerebellum is critical for coordinated movement, and the well-described, stereotyped circuitry of the cerebellum has made it an attractive system for neural circuits research. Much is known about how activity and plasticity in its identified cell types contribute to simple forms of motor learning. In contrast, while gait ataxia, or uncoordinated walking, is a hallmark of cerebellar damage, the circuit mechanisms underlying cerebellar contributions to coordinated locomotion are not well understood. One limitation has been the difficulty in extracting quantitative measures of coordination from the complex, whole body action of locomotion. We have developed a custom-built system (LocoMouse) to analyze mouse locomotor coordination. It tracks continuous paw, snout, and tail trajectories in 3D with unprecedented spatiotemporal resolution and it has allowed us to identify specific, quantitative locomotor elements that depend on intact cerebellar function. Here we will combine this quantitative behavioral approach with electrophysiology and optogenetics to investigate circuit mechanisms of locomotor coordination. We will 1) Optogenetically silence the output of cerebellar subregions to understand their distinct contributions to locomotion. 2) Record from identified neurons and correlate their activity with specific locomotor parameters. 3) Optogenetically stimulate defined cell types to investigate circuit mechanisms of coordinated locomotion. These experiments will establish causal r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DYNAMIC BRAIN FUNCTION: Towards the Understanding and Treatment of Brain Disorders', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

DYNABrain aims to develop, extend and fully unlock the research potential of the Center for Neuroscience and Cell Biology (CNC), through the implementation of a new interdisciplinary research line in the field of Systems Neuroscience that will synergise and uplift CNC’s flagship research domain, Neuroscience, to the EU/ERA level. It will capitalize on CNC’s installed capacity and research excellence in cellular and molecular Neuroscience and Brain Diseases, and establish an ERA Chair in Systems Neuroscience to incorporate the systems-level of understanding brain function and pathology in CNC core research activity. The field has gained center-stage due to recent advances in technology for recording and manipulating neural circuits at single-cell resolution and in vivo, creating new opportunities to investigate how neuronal networks give rise to behavior, and how alterations in their activity relate with neuropsychiatric diseases and with early stages of neurodegenerative disorders. It will greatly contribute to the development of pioneer strategies to treat brain diseases, or to delay/reduce their socio-economic burden.DYNABrain will thus recruit a research team in Systems Neuroscience headed by an outstanding scientist in the field with proven leadership and management competence, to transversally impact on CNC core research activities and synergise its complementary research areas. The CNC Neuroscience ecosystem, immersed in the large R&I network of the University of Coimbra, provides the right setting for the successful integration of the ERA Chair. An innovative International PhD Programme in Integrative Neuroscience will be created powered by the ERA Chair expertise that will boost the competitiveness of CNC graduate school and train the next generation of Neurosci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'NEURONAL SELF-RENEWAL BY ANTIGEN-SPECIFIC TOLERIZATION IN MULTIPLE SCLEROSIS REINSTALLING THE BALANCE BETWEEN INFLAMMATION AND REGENERATION'.

assistant: **Innovation**

Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous system for which no cure is currently available. It is the leading cause of non-traumatic disabling neurological disease in young adults with more than 500,000 people affected in Europe. As chronic inflammatory processes drive the neurodegeneration, we hypothesize that improved clinical outcome can be achieved by restoring the balance between inflammation and the remaining capacity of neuronal self-renewal. In this context, cell therapy that specifically targets the damaging immune reactions that cause MS, thereby reducing the autoreactive, inflammatory assaults in MS without affecting protective immunity against pathogens and cancer, can be a promising approach to allow for more repair. Recently, we set-up a collaborative network of European centers working in cell therapy (COST Action BM1305). From this, a multidisciplinary team from four different EU countries (B, ES, NL and GER) with two additional partners now aims to safely reach the next level of testing and joins efforts to bring antigen-specific cell therapy for MS to the clinic. Our objectives are to evaluate safety, clinical practicality and demonstrate first proof-of-principle of therapeutic efficacy of antigen-specific tolerance-inducing dendritic cells (tolDC) in MS patients in two single-center clinical trials. All regulatory approvals are already in place. Coordinated patient monitoring and centralized MRI monitoring, including radiological correlates of neurodegeneration, and immunomonitoring will enable us to directly compare results between trials and enable consented biobanking, data safeguarding and accessibility to support future efforts in the field of MS therapy. ReSToRe focuses on the advancement of an in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Facility for Antiproton and Ion Research'.

assistant: **Concept**

Subject of this EU project is the implementation of the FAIR GmbH for the construction of the new research infrastructure FAIR. The Facility for Antiproton and Ion Research" is an integrated system of particle accelerators which will provide high energy and high intensity beams of ions from antiprotons to uranium with unprecedented quality for basic research in different fields of physics. The total costs of the FAIR project is 1002 M€ (investment) and 185 M€ for personnel. Under the supervision of the International Steering Committee the scientific and technical preparations of the project have been evaluated and completed. The necessary legal documents for the establishment of international company FAIR GmbH have been worked out. This EU project concentrates on activities which still have to be successfully completed for the implementation of the FAIR project. The most important task is to achieve an agreement on financial / In-kind contributions to the construction of the facility between the 14 FAIR Member countries and the signing of the Convention, the intergovernmental agreement for FAIR. The Work packages of this proposal are legal issues, finances, governance, FAIR line-management and project management, coordination of research and coordination of accelerator. These activities cover also the start-up phase of the FAIR GmbH, until the FAIR project is successfully implemented. The participants of this application are 12 ministries or funding agencies and 14 research institutions. The activities, subject of this EU project, will be performed by the international project team "FAIR Joint Core Team"."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Digital Infrastructures Along the New Silk Road: A Mixed-methods Exploration of China's Digital Investments in Its Borderland Regions' under Horizon 2020.

assistant: **Concept**

As part of its Belt and Road Initiative (BRI), China has recently launched the “Digital Silk Road” program, focused on investments in digital technologies and infrastructure in countries that are part of its loosely reimagined Silk Road. This program is seen as having the potential to create a second, China-led internet, which splits from the US-centered one and is ruled by a different set of priorities and values. Are the Digital Silk Road and the global expansion of Chinese tech companies prefiguring a future with two internets: an existing one that is US-led and founded on market-driven ideology, and a new, alternative one that is China-led and characterized by state control, national boundaries, and national governance over what began as a borderless new space? What values and politics are built into the various components of the Digital Silk Road, and is - or how is - the internet they are creating fundamentally different from the current one? The project will employ qualitative and ethnographic methods, digital methods, and document analysis to understand the emergence of the Digital Silk Road from the ground-up and from the comparative perspective of business, governments, and ordinary people in four countries: China, where Digital Silk Road policies, finances, devices, online platforms and apps originate; Kazakhstan, a key player in Central Asia; Myanmar, whose economic dependence on China is the cause of considerable ambivalence; and Cambodia, that under Prime Minister Hun Sen has been one of the most enthusiastic supporters of Chinese investments.The project aims at illuminating the deployment of the Digital Silk Road to see what this second internet might consist of; seeks to understand what values and politics are embedded in it; and explores how they are re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of a virtual reality technology for sme's in the virtual prototyping" of components and assemblies"' under Fourth Framework.

assistant: **Concept**

There are more than 2,400,000 [1] licenced users of Computer Aided Design (CAD) packages in Europe, covering virtually all industrial sectors for the design and development of new components, assemblies and products. The application of this design tool within engineering and manufacturing sectors is now virtually complete, with 250,000[1]of the licenced users in Europe being manufacturing SMEs. CAD's current use amongst SMEs ranges from it's basic application as a tool to describe geometric form, creating engineering drawings, to its fuller use as a communication medium for component texture, colour and function. The Core Group of Proposers are representative of this range of applications. Since the advent of lower priced component and sub-assembly sourcing into European supply chains from Pacific Rim and former Eastern Bloc countries, domestic manufacturing SMEs, unable to compete on price alone, have started to differentiate their offering by providing increased added value to the first tier suppliers and OEMs (Original Equipment Manufacturers) they serve. This has tended to be acheived through the development of 'prefered supplier' relationships, where a supplier integrates into a customers design and development process, often taking on the detailing and prototyping of a part and in some cases even it's complete design to a performance specification and price constraint. The key to this approach, is better communication of design intent and detail, enabling suppliers to work closely with their clients, as an integrated team to develop concepts into detail designs and then on to prototyping and performance validation. A tool that is already revolutionising concept visualisation and interaction, is Virtual Reality (VR). It is being used today, to communicate concept d