RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Institutional Compatibility Analysis for Resource Use Sustainability'.

assistant: **Objectives**

The Institutional Compatibility Analysis for Resource Use Sustainability (ICARUS) project aims at filling the lack of attention which has been given in agricultural economic literature to institutional causes of unsustainable land use (Oskam, Feng, 2008). This can be done by introducing, both at a conceptual and an empirical level, a formalised methodology to determine how incompatibility between policy instruments (such as rural development measures) and pre-existing institutional settings could influence the sustainability of natural resource use in different European rural contexts. More specifically in this project we would like to focus our attention on the influence of institutional dynamics (such as the effect of introduction of new rural development measures in the working institutional settings of a local context) on land use decision of family-farms, which are, at the moment, the most relevant organisational forms of land management in the European rural areas. Under the common definition of family farms, in fact, it is possible to find all over the European Union Member States a range of different organisational modes or governance structures, which goes from single owner to private limited company in which the family holds all the shares (Slangen et al., 2008). Each organisational form is characterised by a specific decision-making setting but, as a common background, the decisions about resource use are mainly influenced by factors related on the family needs and context relationships. Multiple and sustainable land use provided by a range of multiple farm types is a key-element which characterises the European rurality, and a relevant part of it is constituted by “family farming” land use settings. This is the basic idea around which this project has been p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SMALL-SCALE ANAEROBIC DIGESTION FOR AFFORDABLE, EFFICIENT AND SUSTAINABLE MANAGEMENT OF FARMS WASTE' (GASFARM).

assistant: **Innovation**

Sereco Biotest S.N.C. is an Italian company leader in the field of advanced environmental services. They are specialised providers of fore-front R&D solutions in the environmental technology and industrial ecology fields. This eagerness to find innovative and efficient industry solutions whilst protecting the environment has resulted in the development of GASFARM, a small-size anaerobic digester based on Anaerobic Baffled Reactor technology. GASFARM will be used by small and medium farms (SMFs) from livestock and agricultural industry, currently unable to manage their residues affordably.This novel anaerobic digester is techno efficient, as it is optimized and adapted to small companies’ performance and cost requirements. It allows on-site waste treatment avoiding transportation costs and civil engineering, while recovering valuable resources like biogas or nutrients (N, P).The small-scale anaerobic digester has several technical advantages which overcome the technique barriers that have prevented anaerobic digestion to be successful among small agricultural enterprises. This solution requires far less reaction volumes compared to ordinary Continuous Stirred-Tank Reactors (CSTR), decreases in 50-70% the use of chemical fertilizers, has higher efficiency performance rates and it is easy to install, transport and handle reducing costs. Therefore, the adoption of this small scale anaerobic baffled reactor will become biogas plants a matter of industrial production rather than customized engineering, making the whole process much more profitable.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Generating growth hormone-releasing hormone neurons from human embryonic stem cells' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Hypothalamic growth hormone-releasing hormone (GHRH) neurons stimulate pulsatile pituitary growth hormone (GH) secretion and thereby determine glucose homeostasis and growth in children and eventually adult height. Conversely, growth hormone deficiency is potentially lethal in neonates, and can lead to short stature and significant morbidity later in life. However, the mechanisms of growth hormone deficiency are incompletely understood, since pituitary cells and hypothalamic GHRH neurons are virtually impossible to obtain for disease modelling. The aim of my proposal is to differentiate GHRH neurons from human embryonic stem cells (hESCs), which can self-renew indefinitely in culture while maintaining the ability to become almost any cell type in the human body. My proposal is comprised of three distinct work packages (WP1-3). In WP1, I will develop a conventional growth factor-based protocol for GHRH neuron differentiation by taking advantage of the existing knowledge on signals regulating hypothalamic development. In WP2, I will use RNA sequencing data from WP1 to directly differentiate hESCs to GHRH neurons by CRISPR-dCas9-based gene activation system (CRISPRa), which can temporally control the transcription of desired endogenous loci. In WP3, I will characterize the endocrine and electrophysiological properties of GHRH cells from WP1 and WP2. My project will provide a platform to model genetic causes of GH deficiency, and is expected to be applicable for human growth-modulating drug discovery. The three WPs will be carried out in an excellent training environment at the Stem Cells and Metabolism Research Program at the Research Program Unit (research flagship program of the University of Helsinki, Finland).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dynamic Media Service Creation, Adaptation and Publishing on Every Device' in the context of a Seventh Framework call.

assistant: **Objectives**

We are currently witnessing a strong trend towards powerful web-based applications – a trend which is also driving the progress of HTML5 where a wider range of devices are becoming capable of running such applications.However, most applications are running on these devices separated from each other or, at best are only loosely coupled. The growing interest in 2nd-screen solutions within the Connected TV sector clearly shows that users expect a more consistent experience across different devices and their applications. However, to do this, broadcasters and application developers currently need to implement, distribute and maintain a set of rather complex technical solutions tailored to each of the specific target platforms.A more versatile solution would allow the implementation of applications independent from the target devices and the application itself would be able to run across multiple user devices. The user could then smoothly move parts of the functionality from one device to another in an intuitive manner and the application would adapt itself to the device.Essentially, the challenge is to take connected service development to a new level. MediaScape will lay the foundations for advanced connected multi-user services via a standardised approach integrated into the HTML5 paradigm.The project also seeks to facilitate the marriage of the TV, PC and Mobile worlds through a standard solution that includes real-time delivery and synchronisation of media contents and applications/services across a variety of devices.Working with the W3C and liaising with HbbTV and YouView, MediaScape will enable future services that define multi-user and multi-devices media-viewing experiences for millions of European users, fostering the materialisation of new service concepts and bu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Improving the safety of live attenuated viral vaccines by exploiting RNA silencing pathways' (VIVARNAsilencing2), addressing dissemination and exploitation.

assistant: **Impact**

Live-attenuated viral vaccines are among the most successful vaccine approaches and have been used for decades. However, live-attenuated vaccines come with a risk of reversion or recombination of the vaccine to a virulent form. An important consideration for live-attenuated vaccines for arthropod-borne (arbo-) viruses is that they should not replicate in their mosquito vectors to prevent unwanted spread of the vaccine and vaccine-derived virulent strains. In this ERC Proof-of-Concept project (VIVARNAsilencing2), we will develop an innovative approach to enhance the safety of live-attenuated vaccines for mosquito-transmitted viruses, by preventing their replication in mosquitoes. To this end, we will exploit a small RNA-based gene regulatory network of the mosquito vector to target viral RNA for degradation in the mosquito. The mechanism and natural function of this gene regulatory network had been characterized in an ERC Consolidator Grant, which we will now develop into a commercial and societal valuable product. We will focus on important epidemic human arboviruses with a large disease burden such as dengue virus, Zika virus, and chikungunya virus, but the approach is readily applicable for all arboviruses that are transmitted by mosquitoes of the Culex and Aedes genera, including pathogens of livestock. VIVARNAsilencing2 meets an urgent need in the face of the enormous disease burden and strong global push to develop vaccines for the important class of mosquito-transmitted pathogens.


**Keywords:** viral vaccine, live-attenuated vaccine, RNA silencing, piwi-interacting RNA, arbovirus, mosquito, Aedes, aegypti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Peer ethnography for the promotion of patient and public involvement: young people and sexual health service development.' in the context of a Horizon 2020 call.

assistant: **Objectives**

This project will make an innovative contribution to patient and public involvement (PPI) in health through the application of an innovative peer ethnographic method, which offers the potential for new knowledge unobtainable through other qualitative research methods. A group of young people will be trained to conduct ethnographic research amongest their peers on gender relations, sexual initiation and behaviour, perceptions of sexual health services, and priorities for support. The team of peer researchers will be trained and supported in communicating the findings of their research with key stakeholders working in YP’s sexual health service provision in one region of the UK. The project will have several lasting impacts: it will provide important insight into the value of peer ethnography as a methodology to be used within PPI, contribute to new knowledge for evidence-based policy-making and service provision in the field of YP’s sexual health, and will equip a group of young people (YP) with important research, communication and advocacy skills. The project will enable the beneficiary to develop critical new skills and experience in the implementation and analysis of PPI in health, while at the same time broadening her interdisciplinary experience and expertise in applied anthropological research methods. She will also gain new skills in training and conducting research with YP. Dr White’s employability will be significantly enhanced through the tailored mentoring provided by her supervisor and other experts at the University of West of England (UWE) and the practical skills she acquires working on the proposed project. By the end of the Fellowship she will be equipped with the expertise and experience necessary to pursue an independent research position, enabling he
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Brain Research Area' (EBRA), addressing dissemination and exploitation.

assistant: **Impact**

Brain  research  in  Europe  is  a  rapidly  evolving  field,  and  increasingly  at  the   forefront  of   science. The complexity of understanding physiological brain functions and brain diseases brings responsibilities to develop novel tools and approaches to advance our understanding of unknown basic brain functions, as well as opportunitiesto generate novel therapeutic approaches, thus confronting with a major societal challenge in Europe and worldwide. Considering the costs of brain diseases for the European society, and that these costs will increase considerably in the coming years due to the ageing of the European population, the EU and its Member States have made considerable investments in brain research leading to a significant increase of initiatives in this area. Although these initiatives have generated considerable amounts of knowledge and innovative approaches, the translation into new health interventions is hindered by the complexity of the challenge and by excessive fragmentation of the efforts. Effective and efficient collaboration and cooperation among the various initiatives are often identified as a key success factor to achieve brain research full impact. In particular, there is a constant need for strengthening the information flow and accelerating the exchange of experience on the on-going and future projects as well as maintaining continuous dialogue between all the stakeholder groups and initiatives to allow that objectives are aligned and needs are met. EBRA will fully respond to these needs by bringing together the various stakeholders and major brain research initiatives, at European level and beyond, and creating the conditions for real and effective cross fertilisation, dialogue, building consensus and exploiting research potential to d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Support to EIC Accelerator by the Enterprise Europe Network'.

assistant: **Objectives**

The objective of EEN2EIC is to empower EEN network offices support potential EIC applicants, specifically women entrepreneurs and widening countries, and Seal of Excellence (SoE) holders. The project aims to develop a strong cooperation mechanism between the European Innovation Council and EEN in order to support innovation and scale up companies. EEN2EIC will involve the most relevant actors in the EIC and EEN landscape: the Enterprise Europe Network ( EEN), the EIC NCPs Network (ACCESS2EIC). EEN2EIC aims to focus on specific outreach and support activities, increasing the number of quality proposals to EIC calls with a specific focus in widening countries as well as women innovators, assisting Seal of Excellence holders access alternative sources of funding and guarantee a strong and profitable  exchange of best practice within EEN. EEN2EIC overall objective is to make EU innovation support more efficient by improving the capacity of SMEs to apply to the EIC and by helping SoE holders finance their projects and to avoid overlapping with NCPs activities


**Keywords:** Enterprise Europe Network,  Horizon Europe,  European Innovation Council
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Therapeutic and Biomarker Potential of long non-coding RNAs in Vascular Disease' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The contribution of cardiovascular disease to human morbidity and mortality continues to steadily increase in our aging European society. In response, extraordinary efforts have been launched to determine the molecular and pathophysiological characteristics of its etiology. The collective work of multiple research groups has uncovered a complex transcriptional and post-transcriptional regulatory milieu, which is believed to be essential for maintaining cardiovascular homeostasis. Recently, non-coding RNAs, especially the ones with antisense capabilities such as microRNAs or ‘natural antisense transcripts’ (NATs) have received much attention. They have been identified as important transcriptional and post-transcriptional inhibitors of gene expression. This current proposal describes the development of novel diagnostic and therapeutic strategies to limit the burden of cardiovascular disease in general, and abdominal aortic aneurysms as well as carotid stenosis and subsequent stroke in particular. Using transcriptomic profiling techniques on human diseased tissue samples, we have identified two NATs (SLFNL-AS1 and NUDT6) as novel crucial regulators of smooth muscle cell survival via targeting CTPS1 and the fibroblast growth factor 2 (FGF2) in the vascular system. We are using disease-relevant experimental in vivo models (rodents and LDLR-/- mini-pigs) to functionally assess how inhibition of these two NATs influences aneurysm progression and atherosclerotic plaque vulnerability. One focus of our studies is to utilize local delivery mechanisms for non-coding RNA modulators, such as drug eluting balloons and stents, to enhance the translational feasibility of our findings. Furthermore, we have access to unique human plasma material from patients with early and advanced forms
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'An early stage training network in enabling technologies for GREEN radio' under Seventh Framework.

assistant: **Concept**

Current 4G vision envisages higher data rates and multi standard radio interfaces to provide all users with a continuous seamless connection. The large number of foreseen devices coupled with the surge in power requirements for future emerging handsets raises significant challenges in terms of: i) reducing the energy consumption; and ii) reducing the amount of electromagnetic radiations.GREENET targets the following main objectives:1.Recruitment of  ESRs with the clear and long-term objective to conduct top-notch research and to pursue  research excellence at the national, European, and international levels.2.Develop training and career plans that are personalized as possible to meet the needs and desires of each ESR.3.To allow the ESRs to understand and address key research challenges on energy efficient GREENET communications, that form pivotal societal and economic concerns for Europe within the mid-to-long term.4.Offer to each ESR top-level training and research programs with the twofold objective to reinforce and corroborate their own background, as well as to complement this with active participation in a multi-disciplinary network of research scientists.5.Complement the typical competences of “applied research” with aspects related to project management, intellectual property rights, writing of patents, presentation and communication skills, writing of technical papers, exploitation of technical results and creation of start-up companies, etc.6.Guide and help the ESRs to build the bridge from academia to a remarkable and untactful professional career in either the private or public sectors.