RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Euro-India ICT Co-operation' to be submitted under Seventh Framework.

assistant: **Abstract**

The mission of the Euro-India ICT Co-operation Initiative, builds on the achievements and momentum created by EuroIndia2004 and MONSOON project, whose goals profiled and engaged the widespread Indian ICT research community by analysing its research capacities and priorities. EuroIndia seeks to:<br/>- Identify, exploit and sustain EU and Indian RTD potential through an exhaustive mapping of the Indian ICT knowledge, research and innovation landscape; <br/>- Provide critical inputs to strengthen policy dialogue between the EU's i2010 strategy and the Indian Information Society policy;<br/>- Reinforce the promotion of the EU ICT programme and increase Indian buy-in and participation;<br/>- Network a wide range of stakeholders through an institutional mechanism and a well-defined agenda in order to evolve and support a vibrant EuroIndia ICT research community;<br/>- Synchronise ICT research priorities and objectives.<br/>EuroIndia, owing to its highly qualified and strongly committed consortium of partners, will be in an optimal position to address these strategic needs in objectives comprising: technological mapping activities, survey reporting, communication and outreach to take place in India in the form of Information days, technology brainstorming events and joint EU-Indian ICT workshops, where the project identifies mutual areas of co-operation and collaboration. <br/>These actions will maximise EU and Indian RTD potential, increasing the visibility of EC Programmes in India and preparing groundwork for lasting strategic partnerships. Operationally, the project locates complementary Indian constituencies, understands their potential to formulate objectives of collaboration and initiate partnerships. The ultimate project's objective is to continue to evolve and support
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reviving, Boosting, Optimising and Transforming European Film Competitiveness - REBOOT' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

This project aims to connect the existing strengths, identify and overcome weaknesses and plan for future competitiveness in the fields of policy, practice and experience. More concretely, the project’s objectives are, on the one hand, to explore the long-standing strengths and pervasive gaps in European competitiveness and policies for competitiveness This includes ways of ‘measuring’ ‘analysing’ and ‘evaluating’ the impact of policies and strategic pathways. On the other hand, the project aspires to place attention to the active preparation for the future in the area of audiences by exploring audience preferences and their generation, as well as modes of film content production. The latter are elements which today’s youth will carry and engage with in the coming decades as makers and consumers, as well as industry and policy leaders. Therefore, the consortium interrogates not only the ‘what is’ but also the ‘what has been’ and ‘what will be’ with fresh lenses. REBOOT’s ambition is to provide a full set of knowledge of the European film industry, which maximises its existing strengths, combined with strategic and tactical dimensions of action for the optimisation of the potential held in European youth publics, understood both as emerging audiences and as citizens  Specifically, the ambition of the project combines several dimensions, which reinforce each other but are listed separately for analytical purposes (and in no particular order): a) increasing support for young people’s engagement with European film; b) strengthening the place of the EU in the global audiovisual economy, particularly in light of the rise of video on demand (VOD); c) supporting cultural diversity in the EU film industry; d) addressing the need for a different understanding of competitiveness a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Early detection and screening of hematological malignancies' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Project SANGUINE addresses the objectives raised by the Cancer Mission Call, which emerged from the growing societal challenge faced by European citizens. According to the European Cancer Information System (ECIS), each year, 2.7 million people in the EU are diagnosed with cancer. The SANGUINE project focuses on hematological malignancies, which account for 10% of those cases, and aims to target the four objectives of the Cancer Mission: (1) understanding, (2) prevention, including screening and early detection, (3) diagnosis, and (4) quality of life improvement of the patients and their relatives. The project introduces a novel minimally-invasive blood test that detects and classifies a set of hematological malignancies. The test is based on detecting a combination of epigenetic biomarkers in DNA from peripheral blood cells and in cell-free DNA. The SANGUINE test will provide superior sensitivity at low-cost which is ideal for screening purposes. This is enabled by direct fluorescent labeling of epigenetic marks in patient DNA and its analysis on a custom designed microarray – the HemaChip. SANGUINE team consists of a comprehensive and strong team of expert that will address medical, technological and social aspects of the developed diagnostic test. Expertise from the medical field includes clinical research, technology development and access to patients. This will enable optimization of the test for hematological malignancies following a user-centric approach and experiencing its implementation in “real-life” clinical settings. The social part of the team includes researchers and patient organization that will promote accessibility of the test to patients and individuals at-risk for screening, early detection and disease management, in combination with a study aiming
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Charting Female Property and Patrimonial Rights in Law and Practice Across Western Europe (12th-16th Centuries)'.

assistant: **Concept**

From the mid-12th century, all over Europe, laws started to be enacted that hindered women from acquiring and managing wealth, triggering a long process that on the threshold of early modernity led to a dramatic reduction in their economic opportunities. The importance of the issue is undeniable, not only because female agency has been a central theme in gender studies, but also because the effects of these developments are still felt today, yet the underpinnings of these developments are far from clear. The period which is being taken into consideration coincides with a foundational phase of contemporary Europe which saw profound economic, social and political transformations, changes in family structures, and complex legal developments. So why certain laws began to be enacted at this precise moment? How is the cutback in female economic rights connected to the late medieval developments? To what extent and how did female economic rights vary from one context to another? The aim PatriFem is to provide answers to these crucial questions through an innovative and extensive research covering three regions with extremely diverse characteristics in terms of legal traditions, and socio-economic and political frameworks: Italy, France, and the German-speaking area. Research will involve the collection and management of large data sets. It will be carried out in different archives across Europe using two main bodies of sources: statutes (to chart the developments in property and patrimonial rights) and private sources (eg. notarial records, to observe how laws were interpreted or even preempted in practice). The methodology, which can be adopted for different areas across time, will be instrumental to future research. The data will enable to develop an interactive digital atla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Support of standardisation and harmonisation of water pollution monitoring', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Specific Objectives:1. To explore the feasibility of producing a set of liquid CRMs for the analysis of PAHs in water according to the requirements of the Water Framework Directive and to re-certify three CRMs (pure substances) for PAH calibration;2. To produce a candidate CRM for biomonitoring purposes (Adamussium Colbecki);3. To provide training to EA laboratories participating in IMEP-12 and IMEP- 15 rounds (trace elements in water);4. To provide training in Metrology in Chemistry" (TrainMiC) in support to the Water Framework Directive Anticipated milestones and schedule - Adamussium Colbecki test material produced 28/02/03 - Review on available "organic pollutants-in-water" CRMs published 31/03/03 - PAH CRMs: substances synthesised and purified 31/03/03 - PAH CRMs: identity and purity of substances verified 30/06/03 - Water-based PAH test batch produced and stability tested 30/06/03 - PAH CRMs: homogeneity and stability data established 30/09/03 - PPF for water based PAH CRMs drafted 31/10/03 - PAH CRMs: bottling campaign concluded 30/11/03 - PAH CRMs: certification campaign started 31/12/03 Planned Deliverables Review on the state-of-art on globally available water-based CRMs. Test batch and stability data Candidate CRMs Homogeneity and short-term stability data Bottled candidate CRM Training courses in form of case studies Training course for practitioners in this sector including laboratories from the Candidate Countries.Summary of the Action:The action concerns the provision of tools such as certified reference materials (CRM), test samples, reference values and intercomparison exercises to support the implementation of the Water Framework Directive in the Member States. These tools are needed to achieve comparable water monitoring data, which are at the basis o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Modelling and simulation of impact waves in brain matter' (TBI-WAVES) under Horizon 2020.

assistant: **Objectives**

During the past decade, the brain has been the subject of numerous studies aimed at understanding its function and its behaviour. An important challenge lies in the prediction and the treatment of Traumatic Brain Injury (TBI), which is a major source of death and disability worldwide. In the mechanics community, important efforts have been dedicated to the mathematical description of the response of brain matter to forces, and to the simulation of traumatic events. Nevertheless, further progress is of utmost importance for applications in biomedical engineering and medicine. In facts, despite clear evidence that dynamic solicitations such as impacts play a crucial role in head traumas, several time-dependent effects are often neglected in the modelling (inertia, fluid content, viscous effects, swelling).The main goal of the TBI-WAVES project is to improve the mechanical and computational modelling of head traumas. A first aim is to improve the mechanical modelling of brain matter by accounting for the above commonly neglected effects. A second aim is to develop dedicated head impact simulation tools. The problem will be approached from theoretical and numerical perspectives, based both on the applicant’s and the host laboratory’s expertise. The training programme is exhaustive and will allow the applicant to grow as an independent researcher. The proposed research will foster further developments in this direction, a step which is fundamental in healthcare and for the benefit of society.The applicant is a Franco-German dual citizen, trained in France in applied mathematics, theoretical mechanics, and computational mechanics. He publishes articles in international scientific journals, with topics in applied mathematics and other disciplines. He is requesting funds for tw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A novel approach for modelling the human nose-brain axis in vitro' (Micro-SENSE) under Horizon Europe.

assistant: **Objectives**

Olfactory neurons allow circumventing the blood-brain barrier making this route particularly interesting for the non-invasive intranasal treatment of brain diseases (Alzheimer’s Disease). Moreover, commensal nasal microbes present in the respiratory region, the major surface of the nasal cavity, are assumed to induce health-promoting effects via metabolites as the gut or skin microbiome does. These complex nasal host-microbiome interactions are emphasized when considering that olfactory neurons sense bacterial metabolites like odorants and that a loss of smell is associated with an early stage of brain diseases. Demonstrating the importance of the human nose nose-brain axis its mechanisms are incompletely understood due to the use of currently available over-simplified 2D in vitro as well as animal in vivo models. Animal models provide highly valuable insights into cause-effect relationships, but translation to humans is challenging. Thus, within the Micro-SENSE project, we are proposing to build an advanced bioelectronic 3D model of the human nose-brain axis urgently needed for a better understanding of healthy nose physiology. This 3D bioelectronic platform will connect the recently developed (1) e-Transmembrane device hosting a respiratory nasal organoid and nasal microbes, (2) Microelectrode Arrays with affixed intact olfactory tissue and (3) patch-clamp set-ups for specific olfactory neuron studies. Integrated biocompatible PEDOT:PSS electrodes enable non-invasive monitoring and recording of nasal host-microbiome interactions by measuring epithelial barrier integrity and olfactory neuron firing in real time. PEDOT:PSS scaffolds compartmentalize the e-Transmembrane device for connecting with MEAs and patch-clamp set-ups enabling to study drug and metabolite uptake a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Mechanical regulation of cell migration by Piezo1 and its implications in epithelial cell turnover'.

assistant: **Innovation**

Cancers arise in cell types that turnover by proliferation and death at highest rates, likely because these rates become unbalanced. Our group found that mechanical forces control both processes in epithelia: stretch activates proliferation whereas crowding activates cell extrusion and death. However, it was unclear what causes crowding and stretching forces in epithelia. I will investigate if cell migration from sites of proliferation drives the conveyor belt forces that control stretch-induced cell division and crowding-induced death. If so, the rate of cell migration could drive the rate of cell turnover and, hence, the propensity for a tissue to become cancerous. While my host lab has already identified roles for the stretch- activated ion channel Piezo1 in controlling proliferation and extrusion, based on preliminary compelling findings, I will determine if it also controls cell migration from sites of division. To do so, I will use established models in cell culture and mouse gut and develop an in vivo zebrafish gut model for homeostatic epithelial cell turnover. Additionally, I will test if frequent Piezo1 mutations in colon cancer impact cell proliferation, migration, and death. If my hypothesis is correct, I will reveal a new, unexpected role for cell migration in not only normal epithelial cell turnover but also in carcinogenesis. Should Piezo1 act as a central transducer of mechano-chemical coupling, it could provide a new target for therapeutics.


**Keywords:** Calcium, mechanics, Piezo1, MDCK, zebrafish, migration, division, polarity, extrusion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Characterizing the chromatin landscape of Spinal Muscular Atrophy in response to AAV9 mediated gene therapy' (EpiAAVTherapy).

assistant: **Innovation**

Spinal muscular atrophy (SMA) is a fatal neurodegenerative disorder in children, characterized by motor neuron loss and atrophy of muscle. However, SMA affects many organ systems, since the causal gene, SMN1, is expressed in all cells. Recently, an AAV9-mediated gene therapy, Zolgensma, was approved. However, challenges remain. To be effective, the systemically delivered AAV9- SMN1 needs to mimic the native regulation of the genomic SMN1. In fact, recent findings demonstrated that delivery of AAV-SMN1 under the control of the ubiquitous viral promoter CMV found in Zolgensma eventually caused death of neurons in a mouse model of SMA. To date, there has been no systematic categorization of how treatment with  SMN1 is regulated in different tissues through development. Furthermore, little is understood about the chromatin changes that occur during SMA, how gene therapy impacts the long-term stability of patients epigenomes, or how the AAV-delivered DNA is epigenetically controlled over time. The goal of the proposed work is to understand how the epigenome reacts to gene therapy, using SMA as a model.  To do so I will: i) profile the epigenetic changes during SMA disease progression in mice, before and after gene therapy, ii) evaluate the role of various promoter-enhancer structures in the vector on the epigenetic regulation of AAV-delivered episomal DNA and iii) test if endogenous promoter-enhancer combinations can be used to achieved a better tuning of the delivered gene. The proposed project combines the expertise of Dr. Piera Smeriglio in SMA models, neuromuscular disorders and gene therapy with my expertise in epigenetic profiling, gene regulation, functional genomics, and single-cell technologies. AAV gene therapies are poised to have a huge impact on rare diseases, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Support to Reinforce the European Strategy Forum for Research Infrastructures' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

A 4 year ""Coordination and Support Action"" project led by the Science Technology Facilities Council (UK) in partnership with Universita degli Studi di Milano, (Italy), ATHENA Research and Innovation Centre, (Greece) and German Aerospace Center, DLR (Germany). The goal of STR-ESFRI is to provide support to reinforce the European Strategy Forum for Research Infrastructures (ESFRI)  under the guidance of its Chair, by providing additional resources, tools and expertise for performing its activities and supporting its structures. The main objectives of this project are to provide support to the ESFRI Chair in all ESFRI related activities, to support the process for delivery of the new ESFRI Roadmap, to disseminate and exploit ESFRI related outputs to the European and Global Research Infrastructure Area, liaise with key stakeholders including the e-Infrastructure Reflection Group (e-IRG), to identify best practices and facilitate the exchange of experiences among ESFRI projects and other European and Global Research Infrastructures and finally to monitor projects on the ESFRI roadmap.""


**Keywords:** ESFRI, European Strategy Forum for Research Infrastructures, STR-ESFRI