RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Molecular pathogenesis of persistent hyperinsulinaemic hypoglycaemia: a rational basis for the development of new therapeutic strategies'.

assistant: **Objectives**

Brief Description:PHHI is a consequence of a loss of normal regulated insulin secretion by the pancreatic , (-cell. In some children this is a result of a mutation in one of two genes encoding one of the protein components (SUR1 or KIR6.2) of a (-cell potassium channel (K+ATP ), yet in others, hyperinsulinism is not linked to this genetic locus (1lpl5.1). (-cells from these infants exhibit abnormalities of other ionic channels or ion channel independent abnormalities to account for the unregulated insulin secretion. These differences in cellular pathology in PHHI may account for differences in responsiveness to pharmacological therapies. This programme will isolate genomic DNA from infants with PHHI from a variety of ethnic backgrounds (and their families) to perform detailed studies of genetic linkage to sites within and without 1lpl5.1. Acutely isolated pancreatic tissue will be used to search for somatic mutations which will not be detected in genomic DNA derived from whole blood and to construct a cDNA library. Acutely isolated (-cells will be studied using patch clamp, capacitance and microfluorimetric methods to define ion channel dependent and independent causes for the loss of regulated insulin secretion and the pharmacological manipulation of these processes studied in vitro. Detailed descriptions of genotype / clinical phenotype / cell biological phenotype (in vitro) will be constructed and on the basis of this detailed clinical management guidelines published.Keywords:Hyperinsulinism, PHHI, 1lpl5.1, Linkage analysis, K+ATP channel, SUR1, KIR6.2, (-Cell, LOH, Insulin secretion, Patch clamp, Capacitance, Genotype-Phenotype relationship, Clinical management guidelines.Persistent hyperinsulinaemic hypoglycaemia of infancy (PPHI) is a rare disease in which severe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'KONFIDO - Secure and Trusted Paradigm for Interoperable eHealth Services' in the context of a Horizon 2020 call.

assistant: **Objectives**

KONFIDO advances the state of the art of eHealth technology with respect to four key dimensions of digital security, namely: data preservation, data access and modification, data exchange, and interoperability and compliance. To address the challenges of secure storage and exchange of eHealth data, protection and control over personal data, and security of health related data gathered by mobile devices,  KONFIDO takes a holistic approach – i.e. one targeting all the architectural layers of an IT infrastructure, and specifically: storage, dissemination, processing, and presentation. KONFIDO  builds on and extends the results of a best of breed selection of successful projects, notably: epSOS, STORK, DECIPHER, EXPAND, and ANTILOPE. The approach will be implemented in a technological framework that relies on six technology pillars: 1) security extensions provided by main CPU vendors; 2) security solutions based on photonic technologies; 3) homomorphic encryption mechanisms; 4) customised STORK-compliant eID support;  5) customized extensions of selected SIEM solutions; and 6) disruptive logging and auditing mechanisms. The usability of the proposed solutions will be tested in a realistic setup, deployed on top of a federated cloud infrastructure, where data will be exchanged and services interoperate cross-border.  Experimental evidence will be collected, proving that KONFIDO solutions provide effective protection even against attacks by privileged software (e.g. the Operating System or the Hypervisor) or privileged users (e.g. the System Administrator or the Cloud Provider). Since i) it builds on results that were already widely accepted, and ii) it relies on a handful of complementary technologies (some of which are already at a high level of maturity), KONFIDO has a dra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Fluid-structure interaction and the ground effect in animal locomotion' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The ground effect in aerodynamics is associated with the enhanced lift that results from being in the neighborhood of a rigid boundary. While this effect has been well studied on the large-scale for fast moving objects such as planes, it is also of relevance in animal locomotion in such instances as hovering and skimming in insects, fishes and other flying and swimming animals In a general confined flow, the center of pressure of the moving body does not coincide with the center of mass so that there is a torque imbalance on the body. If the body is elastic, it will deform in response to this torque, a fact that is beautifully demonstrated by the dynamics of a sliding transparency on an overhead projector that floats for a while even as it settles down. The main goal of the project will be to construct a theoretical model for the interaction of fluids with elastic structures in the vicinity of a wall, motivated by considerations of animal locomotion. The content of the proposed project gives the opportunity for applying the techniques of the non-linear dynamics field to the fascinating problem of insect locomotion, and also for learning the Physics and Biology which are necessary to understand that problem. Through this project, I will broaden my understanding of Biophysics, Biomechanics and Elasticity, or more generally Continuum Mechanics. This knowledge will be very useful in the future for studying and solving problems at the interface between Physics and Biology. Because there are experimentalists at DAMTP, it will be possible to have some interaction with them and I will have the possibility to set up an experiment related with my project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Registry of sequenced plant genes', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

1. OBJECTIVES: In 1991 the International Society_of Plant Molecular Biology (ISPMB), recognising that the sequencing of Arabidopsis, rice, wheat and maize genomes and cDNAs would lead to an explosion in the number of known genes, established the Commission of Plant Gene Nomenclature (CPGN), with the object of developing a common nomenclature for sequenced plant genes. This proposal requests funding to establish a European office of the CPGN at the John Innes Centre (JIC, Norwich) under the direction of Dr. Lonsdale (Vice-Chair, CPGN). The office will operate, support and develop the 'Plant Gene Nomenclature' database (MENDEL) at the JIC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'OPTIMIZATION OF ORGANIC THIN-FILM TRANSISTORS FOR PLASTIC ELECTRONICS: TOWARDS TRANSPARENT COMPONENTS IN NEW DEVICES'.

assistant: **Innovation**

Transparent electronics is an emerging new technology which utilizes “invisible” electronic and optoelectronics circuits. To obtain these circuits, the transistor building blocks materials: semiconductor, gate dielectric and conductor must be optically transparent, raising a true grand challenge. The great problem is that conventional organic semiconductors strongly absorb in the visible and few exhibit acceptable TFT performance when processed from solution. This makes clear that there are great opportunities to develop high-performance materials for the fabrication of optically transparent, mechanically flexible optoelectronics. The main goals of this project are: - Develop high-performance, solution-processable, optically transparent organic semiconductor and dielectric materials. - Establish/implement solution deposition/printing processes to achieve multilayers materials deposition with high resolution. - Enable fully transparent, flexible, solution-processed organic TFTs and circuits. - Enable transparent displays. - Analyze the key parameters determining the TFT response. To achieve these tasks, we will carry out these technical goals: - Synthesize and/or optimise new high band-gap molecular and polymeric semiconductors based on rylene, oligothiophene and dicyanomethylene-containing cores. - Functionalize high-purity single-wall carbon nanotubes (SWCNTs) with semiconducting surfactants. - Optimize formulations for solution deposition, focusing on spin-coating and ink-jet printing. - Optimization of layer-by-layer self-assembled nanodielectrics (SANDs) to enhance transparency. - Print crosslinked polymeric dielectric materials on optically transparent substrates. - Evaluate materials performance in various TFT structures on glass substrates. - Characterize spectro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'International case control studies of cancer in relation to mobile telephone use' to be submitted under Fifth Framework.

assistant: **Abstract**

The objective of the proposed studies is to determine whether mobile telephone use increases the risk of cancer and, specifically, whether the radio frequency (RF) radiations emitted by mobile telephones are carcinogenic.Scientific approachMulticentric population based case-control studies will be conducted, focusing on the tumours which, if RF are carcinogenic, are most likely to be related to mobile telephone use: tumours of the acoustic nerve, the parotid gland and parts of the brain (gliomas and meningiomas). The project will be conducted using a common core protocol in 13 countries including 7 from the EU (Denmark, Finland, France, Germany, Italy, Sweden, UK) and 2 associated (Israel and Norway). The inclusion of centres in 13 counties is to maximise statistical power to detect any health effect. Although mobile phone use is now very prevalent, it was much rarer five to ten years ago.In most countries, the study population will be all persons aged 30-59 in the major urban areas in where mobile telephone networks were first set-up. Cases and controls will be recruited over a period of 2 to 3 years. Cases will be confirmed by histology or imaging and the exact location of the tumours determined. Controls will be matched on age, sex and study region. Information on the history of mobile telephone use and on other risk factors will be obtained primarily from a detailed questionnaire administered during an in-person, computer assisted, interview. Indexes of RF exposure to the target organs (and associated uncertainties) will be derived from information on phone use, network characteristics and on re-analyses of existing dosimetric experiments. The accuracy of the proposed indexes will be investigated through validation studies. Joint analyses of the data will be carried
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'INITIATIVE FOR SOFTWARE PROCESS IMPROVEMENT- REGIONS EXTERIEURES' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The objectives of INSPIRE are:to increase the level of awareness regarding the benefits of ISO 9000 and software process assessment and improvement,to facilitate the improvement process via appropriate training,to promote the use of software process assessment and improvement techniques via focused improvement projects,to encourage cooperation between software organisations throughout Central and Eastern Europe to share knowledge and experience and form links leading to mutual benefits.These objectives will be achieved by conducting a major training needs analysis, or user survey, in each targeted country and using the results of this survey to plan a coherent programme of awareness and training events. In addition, a number of organisations in each country will be selected as the targets for focused software process improvement activities and mentoring support. The companies will be selected in a manner that will ensure the broadest possible spread of company size and industrial sector. The experience gained by these companies will be disseminated widely both inside and outside Central and Eastern Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Health Information Network in Europe' under Fifth Framework.

assistant: **Concept**

In order for Information and Communication Technologies (ICT) to help the health delivery systems to become more effective, it is necessary to have comprehensive and reliable information on the market. All the players recognise this need as crucial. But this information is not currently available. HIN-EUROPE aims at providing a generic data and information on-line repository services to help all players develop new models of Healthcare employing ICT. This project represents the first element of a process to generate informed investment to deliver ICT-based services, which will provide citizens public access and information sharing amongst all the actors. The project has also for objective to become permanent, self-sustainable and to develop further to meet the changing demands (e.g. countries, market segments, information, services)Objectives:Collecting and sharing data on the current level of usage of ICT as well as anticipating which health delivery systems will be in place in the future and how ICT could help this is critically need by any player who plans to be active in the health sector, public authorities, health professionals, patient organisations, pharmaceuticals, ICT suppliers and services providers, etc. Europe has for the moment a lead in e-health movement but this cannot be sustained without the sort of generally available information that this project will provide. Europe has to consolidate this lead so that it can be cost-effective in terms of health delivery systems and competitive in terms of e-health products and services on a global basis.Our project has therefore two main objectives:- to build an innovative European Health ICT information knowledge based network;- to produce a business plan which will make possible the development of on-go in access
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Developing self-assembling cyclodextrins to tackle the cytopathic activity of respiratory pathogens' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The covid-19 pandemic has arisen awareness about the importance of developing tools to fight viral infection. However, there is still a lack of products to be used by the public as preventive systems against respiratory pathogens. Different systems have been developed to target SARS-CoV-2 using its affinity for different ligands. However, a multivalent presentation of these ligands is necessary to overcome their low affinity, which often implies complex structures difficult to synthesise and characterise. CD-ResVir aims to overcome those challenges. Our group has a wide experience in the exploitation of cyclodextrin (CD) conjugates to create self-assembling systems. These can be functionalised with a ligand to target a pathogen, leading to a multivalent supramolecular scaffold. The great advantage of supramolecular assemblies over covalent strategies is their structural adaptability to the target, i.e. the assembly will adopt the most stable state, the one with maximal interactions. It is also very simple to mix self-assembling components to optimise the effect.  In preliminary experiments, we have obtained robust data proving that a sialic acid-functionalised CD scaffold could offer protection to cells exposed to SARS-CoV-2, which has never been proved before with a supramolecular assembly. Here, we propose to optimise the system and go beyond, expanding the scope of respiratory infections that could be addressed, targeting different respiratory viruses and bacteria. The Chemical Biology processes behind this application will be studied, from the atomic level (interactions between CD and SARS-CoV-2 receptors) to the microscopic level, (templating effect of a virus for the self-assembly of our CD system). Pursuing a groundbreaking preventive nasal spray against respirat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Politics of Marine Biodiversity Data: Global and National Policies and Practices of Monitoring the Oceans' (MARIPOLDATA), addressing dissemination and exploitation.

assistant: **Impact**

In order to protect marine biodiversity and ensure that benefits are equally shared, the UN General Assembly has decided to develop a new legally binding treaty under the United Nations Convention on the Law of the Sea. Marine biodiversity data will play a central role: Firstly, in supporting intergovernmental efforts to identify, protect and monitor marine biodiversity. Secondly, in informing governments interested in particular aspects of marine biodiversity, including its economic use and its contribution to biosecurity. In examining how this data are represented and used, this project will create a novel understanding of the materiality of science-policy interrelations and identify new forms of power in global environmental politics as well as develop the methodologies to do so. This is crucial, because the capacities to develop and use data infrastructures are unequally distributed among countries and global initiatives for data sharing are significantly challenged by conflicting perceptions of who benefits from marine biodiversity research. Despite broad recognition of these challenges within natural science communities the political aspects of marine biodiversity data remain understudied. Academic debates tend to neglect the role of international politics in legitimising and authorising scientific concepts, data sources and criteria and how this influences national monitoring priorities. The central objective of MARIPOLDATA is to overcome these shortcomings by developing and applying a new multiscale methodology for grounding the analysis of science-policy interrelations in empirical research. An interdisciplinary team, led by the PI, will collect and analyse data across different policy-levels and spatial scales by combining 1) ethnographic studies at intergover
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'GNSS/INS Low-cost Attitude Determination and navigation system - Phase 2'.

assistant: **Objectives**

GLAD-2 is aimed at the industrialisation of an innovative product (GNSS low cost and highly accurate attitude determination system, reinforced magnetic immunity) and its commercialisation plan. The innovative and technologically advanced prototype (TRL6), outcome of an FP7 project, (with proven feasibility through SME-INST-1 project) will be transformed into a TRL9 profitable product. It avails an identified business opportunity derived from the UAS/RPAS expansion and lack of high precision and low cost positioning solutions. This will be done in parallel to the regulation harmonisation in Europe, thus fostering this niche market, mainly in the civilian professional sector, for precision accuracy and/or magnetic interference sensitive applications. ACORDE expects to reach the 5% European market share, offering this product to autopilot/sensor developers, UAS integrators and UAS manufacturers, what will imply a cumulative turnover of 8.5M€ and cumulative profit of 1.6M€ in the 2016-2022 period, generating 5 FTE positions in the company. Since the company strategy is based on high technology engineering connected to radiofrequency and satellites, creating robust, reliable and high performance products, it is clear that the goal pursued in GLAD-2 is absolutely aligned with the corporate strategy, complementing the high-tech offering, consolidating the UAS supplier capabilities, and exploiting an experienced R&D line within the company. Therefore, this opportunity represents a key milestone in the strategic implementation plan: not only will promote the GNSS/Galileo products market activity, but also will open new niche markets for the company, thus increasing the probabilities of synergies, cross sales and incremental selling, creating a virtuous circle with the rest of th