RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Natural Program Repair' (NATURAL), addressing dissemination and exploitation.

assistant: **Impact**

Automatic bug fixing, i.e., the idea of having programs that fix other programs, is a long-standing dream that is increasingly embraced by the software engineering community. Indeed, despite the significant effort that humans put into reviewing code and running software test campaigns, programming mistakes slip by, with severe consequences. Fixing those mistakes automatically has recently been the focus of a number of potentially promising techniques. Proposed approaches are however recurrently criticized as being shallow (i.e., they mostly address unit test failures, which are often neither hard nor important problems). Initial successes in automatic bug fixing are based on scenarios such as the following: when a bug is localized, patches are generated repetitively and automatically, through trial and error, until a valid patch is produced. The produced patch could then be later revised by developers. While the reported achievements are certainly worthwhile, they do not address what we believe is a more comprehensive challenge of software engineering: to systematically fix features of a software system based on end-user requirements. The ambition of NATURAL is to develop a methodology for yielding an intelligent agent that is capable of receiving a natural language description of a problem that a user faces with a software feature, and then synthesizing code to address this problem so that it meets the user's expectations. Such a repair bot would be a trustworthy software contributor that is 1) first, targeting real bugs in production via exploiting bug reports, which remain largely under-explored, 2) second, aligning with the conversational needs of collaborative work via generating explanations for patch suggestions, 3) third, shifting the repair paradigm towards the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Optimizing Production and Logistic Resources in the Time-critical Bio Production Industries in Europe', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The CLARUS project aims to connect the Sustainable Paradigm in the food industry and AI-based applications, with the goal of developing a platform with high communications and processing capabilities, as well as the use of standardized open protocols and data models that will allow resource consumption assessment and traceability for food industry processes.The project will be submitted under the call HE-CL4-DIGITAL-EMERGING-01-09: AI, Data and Robotics for the Green Deal and will target the non-robotic outcome. Currently, two pilots have been selected for validating the CLARUS solution. The first pilot focuses on the production of the frozen food, where energy and water consumption can be reduced using AI and data technologies. The other pilot focuses on the meat by-product production where the aim is to reduce the energy and maintain the quality of the products by optimizing the logistics of the by-products arrival. CLARUS ambitions include not only contributing to resource and logistic optimization methods through the two pilot solutions, but also making a more general contribution through the creation of a Green Deal Index (GDI).


**Keywords:** Sustainability; Environmental impact assessment; Green Deal; Food Processing; Natural Resource Consumption; Data-driven architectures
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Assisted Migration of Forests as a climate change economic mitigation strategy' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Adapting forests to climate change in a sustainable way is one of the most difficult challenges faced by scientists because of the uncertainty of climate change, and the pressures imposed to managers to act today that cannot be ignored. The main purpose of our proposal is to provide new ecological, economic and legal tools to address adaptation and mitigation of forests to climate change at the national (France) and European level.A fundamental problem is the management practices to mitigate the effects of climate change. In order to survive, trees should be adapted to current conditions and to those expected under global warming by the end of the century. However, natural populations will not always be adapted to the expected climate change, and therefore mitigation strategies must be adopted. One increasingly studied mitigation option to protect biodiversity in the face of climate change is assisted migration (AM), by which populations are intentionally relocated in northern areas or higher altitudes to compensate for observed or expected climate change to increase population survival and maintain ecosystem services. The benefits and drawbacks of AM in forests remain largely unknown in Europe. Tree species have been moved for different purposes before, but the aim of creating stable forests under a changing climate and not compromising local biodiversity and ecosystem services is a new challenge whose risks must be evaluated.The work proposed in this project involves the evaluation of multi-species and multi-AM scenarios of survival-adaptation, productivity and assessment risk scenarios.Our main goal is to produce scenarios (theoretical representations) of AM for European forests that would imply altitudinal and latitudinal assisted migration actions to mitigate clima
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'First European System for Active Debris Removal with Nets' (ADR1EN) targeting Horizon 2020.

assistant: **Abstract**

STAM, SKA and OptiNav are three high-tech SMEs, that have developed and validate till TRL 6 a system for active debris removal with nets, through an ESA contract (4000109361/13/NL/RA) within the Clean Space initiative. ADR1EN aims at the business opportunity generated by the need to increase safety of space infrastructures, which are menaced by the huge number of space debris lost in space. In line with our product/service roadmap and the short to medium term market needs identified by the detailed Business Plan elaborated, we have identified the SME Instrument as the most valuable tool to support the financial risks involved in addressing the remaining technical and non-technical barriers to market. The objective of the project is to validate by testing and qualify for space a scaled-up demonstrator of the First European System for Active Debris Removal with Nets (ADR1EN) and develop the necessary business and commercialisation plans to reach the market and boost the growth of our companies. The system will be pushed to TRL 7 to show its applicability to real cases and to confirm that ADR1EN is the cheapest and most reliable system for capturing free objects in space. As a result, in line with the priorities set by ESA and NASA, the system will be cost-effectively used by a community of users, namely Thales-Alenia Space, GMV and Airbus, to catch large debris in Low Earth Orbit region, representing a market worthwhile 450 MEuro, associated with the currently mapped 5,000 defunct satellites and related debris. Thales-Alenia Space, one of the largest industrial players in the space industry, has expressed its interest in the system and will act as subcontractor, to complement our capabilities and facilities. Their role is fundamental to ensure that we keep the full contro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Highly mismatched alloys to implement multiband solar cells' under Seventh Framework.

assistant: **Concept**

As it is well-known, it is a fact that one of the biggest problems that concern the current world is relative to the high energy consumption. This proposal is relative to the solar cell, in special with the third generation. This new generation of solar cells is created to obtain high efficiency and low cost conversion devices. Therefore, they are a potential component for the future. The proposal presents the know-how for the design, growth and improvement of the multiband solar cell. So far, this kind of solar cells are a specific topic of the Renewable Energies in the European Union Seventh Framework Program (FP7). However, despite a considerable effort of many research groups, there was no evidence of a working multiband photovoltaic device. Recently, the applicant, within a group at the Lawrence Berkeley National Laboratory in the USA, has designed, grown, tested and demonstrated the first multiband device, growing by dilute nitrogen, and being this concept the transfer technology relate to this proposal. Relying on the technological capabilities of the host institution, its deep knowledge on nanotechnology and its recent activities on new efficient solar cells, the new incorporated know-how will boost the activities of host institution to the topmost frontier of knowledge and development within the solar energy field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Two-photon all-optical interrogation of auditory cortex circuit supporting working memory representations' to be submitted under Horizon Europe.

assistant: **Abstract**

Working memory refers to the brain capacity for encoding sensory stimuli and maintaining information suspended for imminent processing, over a short timespan (few seconds). This ability is crucial for numerous simple and intricate tasks in humans and animals (keeping in mind a sequence, learning, speech…). Despite its importance, the mechanisms underlying this process remain largely unknown. Different theoretical models have been proposed to recapitulate working memory. Among them, attractor dynamics within recurrent networks facilitate self-sustained activity that holds information as a form of memory. Working memory, since its first descriptions, has been pinpointed to higher-order associative frontal and prefrontal regions of the brain. However, growing evidences suggest widespread representations, spanning also sensory cortices. A recent research causally demonstrated the necessity of the primary auditory cortex to perform an auditory-based working memory task. The main objective of the proposed project is to reveal the existence of working memory representations in auditory cortex and to analyze the circuit supporting them, employing the concept of attractor dynamics. This goal will be achieved by combining ultrafast acousto-optic two-photon (2P) calcium and voltage imaging, precise optogenetics and animal behavior. This approach will provide information regarding the spatial organization and identity of neurons responding during the retention phase of the task and enables the subsequent manipulation of such neurons with unprecedented spatiotemporal accuracy. Perturbation experiments will test the predictions of attractor dynamics theory in relation to working memory representation and probe synaptic connectivity within functionally identified neurons. In conclusio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The integration of mechanical and chemical signals in neuronal guidance' to be submitted under Horizon 2020.

assistant: **Abstract**

During the development of the central nervous system (CNS), neurons extend axons through a crowded environment along well-defined pathways to reach their distant targets. It isA start date of 1st June 2018 is being requested to enable the PI to complete a number of current commitments and put the necessary arrangements in place to enable an efficient start up phase of the project.  evident that attractive and repulsive guidance cues in the tissue provide important biochemical signals to guide growing axons along their paths. This can only be part of the story, however, as it is still not possible to predict axonal growth patterns in vivo. In a recent breakthrough discovery, we provided in vivo evidence that neurons also respond to mechanical cues, such as local tissue stiffness, suggesting that mechanical signals are likely an important missing part of the puzzle. However, mechanically activated signaling pathways are currently poorly understood, and how neurons integrate mechanical and chemical signals to result in proper outgrowth is unknown. By investigating how mechanical signals control neuronal growth and pathfinding, this proposal will close this comprehension gap. By combining state-of-the-art approaches in physics, engineering and biology, we will, for the first time, identify mechanosensitive molecular mechanisms that regulate neuronal growth and guidance in vitro and in vivo. In particular, we will investigate how mechanotransduction cascades (1) directly modulate axon growth by inducing local changes in cytoskeletal dynamics, and (2) indirectly lead to alterations in axon outgrowth by modulating chemical signalling pathways. Ultimately, we will develop a computational model based on our findings, which will lead to a predictive framework for understanding ax
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Global views of cell type specification and differentiation'.

assistant: **Concept**

Each cell in our body has a specific biography that is defined by its pedigree relationship with other cells (lineage) and by its history of gene expression (trajectory). A fundamental question in cellular and developmental biology has been how the lineage and trajectory of a cell lead to its specification and differentiation. Remarkable progress in genome editing and single-cell sequencing has generated the opportunity to understand this process at global scales and single-cell resolution. We have recently developed methods to reconstruct the cellular ancestry and transcriptional trajectories of cells during embryogenesis. The resulting lineage and trajectory trees can be analyzed to gain comprehensive views of how cellular diversity arises and how differentiation leads to physiologically specialized cell types. To generate such global views of cellular development, we will:  1. Define the cellular diversity and gene expression trajectories during zebrafish embryogenesis and organogenesis. Trajectory trees will be generated from scRNA-seq data and analyzed to reconstruct the gene expression pathways underlying fate specification.  2. Reveal the relationships between lineage and transcriptional trajectories during fate specification. Lineage trees will be generated by marking cells via genome editing and combined with trajectory trees to reveal the cellular paths towards fate specification.  3. Discover the gene expression cascades that remodel cells into physiologically functional types. Cell biological modules will be identified by comparing gene enrichment in differentiation trajectories and reveal the specialized and shared mechanisms of differentiation.  These studies will help provide the first comprehensive and global view of the trajectories and lineages underly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Framework to respond to regulatory needs of future nanomaterials and markets' (FUTURENANONEEDS) targeting Seventh Framework.

assistant: **Abstract**

Rapidly developing markets such as green construction, energy harvesting and storage, advanced materials for aerospace, electronics, medical implants and environmental remediation are potential key application targets for nanomaterials. There, nanotechnology has the potential to make qualitative improvements or indeed even to enable the technology. Impacts range from increased efficiency of energy harvesting or storage batteries, to radical improvements in mechanical properties for construction materials. In addition, concerns of these markets such as scarcity of materials, cost, security of supply, and negative environmental impact of older products could also be addressed by new nano-enabled materials (e.g. lighter aircraft use less fuel).FutureNanoNeeds will develop a novel framework to enable naming, classification, hazard and environmental impact assessment of the next generation nanomaterials prior to their widespread industrial use. It will uniquely achieve this by integrating concepts and approaches from several well established contiguous domains, such as phylontology and crystallography to develop a robust, versatile and adaptable naming approach, coupled with a full assessment of all known biological protective responses as the basis for a decision tree for screening potential impacts of nanomaterials at all stages of their lifecycle.  Together, these tools will form the basis of a “value chain” regulatory process which allows a each nanomaterial to be assessed for different applications on the basis of available data and the specific exposure and life cycle concerns for that application.  Exemplar materials from emerging nano-industry sectors, such as energy, construction and agriculture will be evaluated via this process as demonstrators. The FutureNanoNeed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Regulation of Chromatin by Combinatorial DNA and Histone Modifications' (ROCCOMO).

assistant: **Innovation**

The normal expression of genes is tightly regulated. Modifications on histones or on DNA play a central role in the control of gene expression and errors in their regulation often result in diseases such as cancer. These modifications can recruit proteins that regulate chromatin function. Since chromatin is a large macromolecular assembly, modifications most likely act in a concerted manner. However, it is still unclear how the information encoded in combinatorial modification patterns on the DNA and histones is translated into biological signals.My aim is to understand how combinations of DNA and histone modifications regulate the activity of chromatin. I will employ the tools of chemical biology, biochemistry and proteomics in conjunction with tissue culture models in order to identify proteins that can recognise DNA and histone modification patterns in the context of chromatin.I propose to use native chemical ligations to generate a library of histone proteins that carry combinations of modifications that are known to mark specific genomic loci. These histones will be assembled into chromatin together with methylated DNA in order to mimic functional genetic elements such as heterochromatin, promoters or enhancers. I will use the recombinantly defined chromatin in chromatin modification, chromatin remodelling and SILAC affinity purification assays in order to identify novel factors that recognise combinatorial modifications. The SILAC affinity purifications will be linked to a primary cell cancer model in order to identify factors that regulate central tumour suppressor genes. The identified factors will be further characterised in vivo, in vitro and in structural studies in order to understand their molecular function. These experiments will identify factors that can