RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Insular cortical circuits controlling fear and anxiety' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

How do emotions guide our behaviour? For an appropriate behavioural response, an individual has to constantly integrate bodily feelings, emotional states, and cues from the environment to evaluate the risks and benefits of a future action. A growing body of evidence indicates that the insular cortex, as part of a distributed neuronal network, plays a key role in influencing emotional behaviour. However, how neuronal circuits within the insular cortex function mechanistically is not known.In this proposal, I will focus on the largely overlooked role of the insular cortex in mediating fear- and anxiety-related behaviours. I will address how the insular cortex processes sensory information of different emotional valence, whether it predicts risk, and how it influences emotional behaviour and decision-making. I will present a research program relying on modern tools to dissect neuronal circuit architecture and function in the mouse, such as viral tracing techniques, optogenetics, behavioural analysis and in vivo two-photon imaging in awake behaving mice.Taking advantage of the technical expertise of my lab, we will reveal the architecture of connectivity-defined insular cortical microcircuits using monosynaptic viral tracing tools. We will address the necessity and sufficiency of connectivity- and cell-type defined microcircuits to express anxiety and learned safety using optogenetic manipulations. In vivo two-photon calcium imaging in awake behaving animals will allow us to examine how representations of sensory cues predicting danger or safety are processed in the insular cortex, which information amygdala afferents carry to the insular cortex, and whether and how neuronal processing in the insular cortex signals risky or safe outcomes. The ultimate goal of this proposal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integral Security  Trust Element for the Internet of Things' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Intrinsic-ID is a Dutch SME, spin-off from Philips Research, and a world leader in security solutions for chips, with 25+ patents. Intrinsic-ID has created a technology to uniquely identify and authenticate chips based on the inherent characteristics of their memory component (SRAM). This technology, a digital equivalent of a fingerprint, is called Physical Unclonable Function (PUF).Intrinsic-ID is working on INSTET – a fully-fledged security solution on top of PUF that will protect low-end chips that are omnipresent in IoT devices everywhere by making them physically and cryptographically secure and extremely resilient to advanced attacks. INSTET will work as a Root of Trust, i.e. a set of core software components that are always trusted by the chip, and provide a trust foundation for the IoT device and distributed IoT systems.INSTET addresses the core problem of semiconductor vendors and OEMs: lack of security. INSTET can be deployed on almost any chip, including the ones that are already in the field, without costly redesigns or additional hardware, generating savings of up to 35% per chip.In this 6-month feasibility study, Intrinsic-ID will investigate the product/market fit and business model fit in three most promising vertical segments of the semiconductor industry (wearables, medical electronics and automotive), develop a go-to-market strategy and calculate costs of scaling up.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ProGeo' (ProGeo) under Horizon 2020.

assistant: **Objectives**

PLC System is an Italian medium company acting as a EPC and/or supplier for electrical plants/substations engineering and construction and as a IPP (independent power producer). The high technical and managerial capacity allowed to PLC to reach a consolidated position in the European energy sector, with a 2015 turnover of 35 M€ and a 85 figures staff, mainly composed by engineers and high level technicians. PLC is very active in the energy R&D, with the clear scope to fabricate and install its own products to be offered in the very competitive energy market. Within this framework, PLC developed ProGeo, a 500 kW Power-to-Gas modular unit able to store electricity by converting carbon dioxide (CO2) into synthetic methane (CH4) with high flexibility thanks to fast start-ups and shut-downs. The patented product will be offered to owners and managers of small Thermoelectric Generation (s-TEG, < 50 MWth) plants, who will have the possibility to store energy and avoid the sale of low-price electricity during low peak requirements (electricity market price < 20-30 €/MWh) and to reduce the CO2 emissions and the consequent carbon tax amount (5 ÷ 20 €/ton of CO2), producing an additional revenue source from the synthetic-CH4 generation. ProGeo will provide customers with the following benefits:• increasing of average electricity sale price = +25%• reduction of CO2 emission and tax = -10%• increasing of TEG plant EBITDA = up to 1 M€/y for a 20 MWel natural gas fuelled power plant• ProGeo pay-back time = 3 ÷ 4.5 years• reduced start-ups / shut-downs of the TEGPLC has developed a pilot prototype of 30 kWel, by which the technology potentialities have been demonstrated, has identified a strategic partner (LAMEP, a company operating in the field of precision engineering) and has define
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'DIGItal MAterials CharacterisatioN  proof-of-process auto assembly'.

assistant: **Concept**

The project’s proposition and charter is to advance (MRL4 > MRL6) the critical steps of the PEM fuel cell assembly processes and associated in-line QC & end-of-line test / handover strategies and to demonstrate a route to automated volume process production capability within an automotive best practice context e.g.  cycle time optimization and line-balancing, cost reduction and embedded / digitized quality control. The project will include characterization and digital codification of physical attributes of key materials (e.g. GDLs) to establish yield impacting digital cause and effects relationships within the value chain, from raw material supply / conversion / assembly through to in-service data analytics, aligning with evolving Industry 4.0 standards for data gathering / security, and line up-time, productivity monitoring. The expected outcome will be a blueprint for beyond current state automotive PEM fuel cell manufacturing capability in Europe.    The project will exploit existing EU fuel cell and manufacturing competences and skill sets to enhance EU employment opportunities and competitiveness while supporting CO2 reduction and emissions reduction targets across the transport low emission vehicle sector with increased security of fuel supply (by utilizing locally produced Hydrogen).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Role of Dendritic Cell Subsets in the Maintenance of Effector and Regulatory T-cells in the Skin' in the context of a Seventh Framework call.

assistant: **Objectives**

Tissue immune homeostasis is dependent upon a dynamic balance between effector T-cells (Teff) and regulatory T-cells (Treg). Biological variables that perturb their ratios are critical determinants in the development of autoimmunity. How this balance is established and maintained in peripheral tissues is largely unknown and is therefore essential for understanding the pathogenesis of autoimmunity and chronic tissue inflammation. Current therapies focus on reducing pathogenic Teff responses while augmenting suppressive Treg pathways. Tissue-resident dendritic cell (DC) populations are intimately associated with tissue-resident T-cells. It is well documented that inflammatory conditions alter the function of DCs, which in turn influence T-cell differentiation towards Teff and Treg cells. We hypothesize that skin DC subsets will have specific and distinct roles in establishing and maintaining peripheral Teff and Treg cells, and in doing so, play a major role in maintaining self-tolerance in the skin. Utlising a novel and unique experimental model whereby self-antigen is inducibly expressed in the skin, this proposal will dissect the role of tissue DCs in: 1) generating Teff and Treg populations in the skin in response to cutaneous self antigen expression; 2) deleting Teff cells upon persistent self antigen expression; and 3) maintaining Teff and Treg memory populations in the skin. It is becoming increasingly apparent that the dominant mechanisms of immune regulation occur within peripheral tissues at the sites of antigen expression and not in secondary lymphoid organs. To elucidate whether skin DC subsets mediate their effects in the skin or skin draining lymph nodes we will employ highly advanced two-photon laser scanning microscopy to compare DC-Teff and DC-Treg interac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Exploiting new solutes from hyperthermophiles for the preservation of biomaterials: cell factories for production of hypersolutes' (HYPERSOLUTES) under Fifth Framework.

assistant: **Objectives**

Hyper solutes, compatible solutes from hyperthermophiles, are superior to their mesospheric counterparts in the preservation of the performance of a wide variety of biomaterials, ranging from proteins to whole cells, skin and artificial tissues. A major bottleneck for industrial applications of hyper solutes is the large-scale production at a competitive cost. The major goal of this project is the development of cell systems eternised for the production of mannosylglycerate; the most widely distributed hyper solute. Two strategies will be pursued:i) engineering of expression and secretion systems in suitable hosts;ii) optimisation of fermentation of natural producers. Trials will be conducted that will widen the range of application of mannosylglycerate. The involvement of industrial partners ensures that the results will reach end-users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Auto-Producing TV Broadcasting System for Sport Events' under Horizon 2020.

assistant: **Concept**

Sport event broadcast is too expensive: a single match costs €9,000-€30,000 and requires intensive equipment installation and manual operation in situ. Minority or emerging sports find tremendous difficulties to keep on stage and gain penetration (example: female sports are only 16-20%). Additionally, broadcasting infrastructure produces intrusion in the facilities and cannot be leveraged to be used for other purposes (i.e. replay analysis, coach tactics analysis, etc.) and capital expenditure of broadcasting rights in top-tier leagues and teams is increasing the breach with 2nd-tier and local teams.As a result, there is a need to reduce the cost and infrastructure to broadcast a match, considering younger population preference is moving from TV to social media and online devices, most of the huge amount of data produced during a match is missed when there is no recording mean or can be only interpreted by human analysisKeemotion is a hardware + software solution to produce live online broadcasts of basketball and other indoor matches with unmanned operation and minimum equipment, that is, affordable price for leagues, coaches and broadcasters.It consists of a single device with 3 cameras + Artificial Intelligence for automated virtual camera; a virtual camera that simulates the movement of typical TV broadcasts with human operators; smart tagging feature to provide advanced analytics about the match and players’ performance; instant replay for referee assistance and real-time streaming broadcast for all digital devices (mobile, smart TV, computers) including integration with social media.Our customers (leagues, coaches/teams and broadcasters) will benefit from:- 80% savings Vs. conventional broadcasting- A turnkey solution (zero setup effort)- No transportation and no
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced Atmospheric Carbon Capture Technology' (AACCT).

assistant: **Innovation**

Ever increasing atmospheric CO2 concentrations and global emissions of 36 Gt/year impose unprecedented threats to the world’s ecosystem and endanger industrial human activities in their entirety. This AACCT project will establish a new advanced technology that facilitates efficient CO2 capture from air and results in a commercial, stand-alone prototype that will demonstrate its economical and ecological viability, outperforming all other emerging approaches to atmospheric CO2 capture. The technology takes advantage of unique, intrinsic micro- and macro-molecular structures of porous materials that were developed within the ERC SUPRAMOL and Science Foundation Ireland funded projects. These adsorbents reveal extraordinary affinity to CO2, are non-corrosive, non-toxic and are based on stable, cheap and abundant silica materials. The system operates in moist air whereby the CO2 recovery is facilitated at mild conditions under which the adsorbent is regenerated. These intrinsic characteristics in combination with the macro-structure of sub-millimetre pellets that enhances the ad/desorption kinetics, results in exceptionally low operational CO2 capture costs. The technology is modular and the number of capture units scales linearly with the desired CO2 quantity. It is not restricted to fixed locations or CO2 point sources and thus, can conceptionally lead to negative or net zero CO2 emissions. The AACCT technology will provide pure CO2 that can be sold, used or transformed within established or emerging chemical processes (i.e. methanol synthesis). Initially, it is envisaged that the systems, using low-grade waste heat, will be employed in energy-intensive industrial sectors requiring air circulation and cooling devices. A very modest adaptation of the AACCT prototypes can fa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ribonuclease meeting' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

6th International Meeting on Ribonucleases Pancreatic ribonuclease, the focus of highly productive scientific research for more than a half a century is the only enzyme to be the basis for four Nobel prizes. There is now resurgence in interest in this superfamily since members have functions ranging from tumour growth and inhibition to self -recognition and neurotoxicity . The proposed 6th International meeting on ribonucleases aims at gathering scientists from various parts of the World with an aim to stimulate interest, provide an overview, and discuss the future prospects into research on ribonucleases. In this context, we are grateful to the organisers of previous five international meetings on this topic (held every three years in different parts of the World) who share our convictions on ribonucleases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Multicomponent Supramolecular Structures as Artificial Enzyme Mimics' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Supramolecular polymers (SPs) are at the forefront of current research to functional bio-mimetic materials and systems. Among the plethora of SPs appeared in the literature in the last decades, those based on 1,3,5-benzenetricarboxyamide (BTA), which have shown to form double helical fibres both in organic and aqueous solution, have been employed as a robust platform for the design of bio-inspired materials with tailored and tuneable properties. Indeed, non-covalent synthesis allows to easily obtain a wide range of functional SPs by simply mixing chemically distinct monomers in solution, which will spontaneously self-assemble into dynamic structures. Such approach has been exploited to develop BTA-based SPs able to bind nucleic acids in a superselective fashion through multivalent interactions between positively charged co-assembled BTA monomers and the phosphate present in the oligonucleotide backbone. Building on these previous findings, MuST ArtEM aims to develop functional SPs to be exploited as artificial nucleases, able to recognize and cleave RNA. The recognition and the hydrolytic activity are provided by cationic components bearing the 1,4,7-triazacyclononane-zinc complexes (TACN-Zn2+), which is well known to catalyse the hydrolysis of phosphodiester bonds. The positively charged components undergo clustered upon binding with the oligonucleotide, thus enhancing the hydrolytic ability of the zinc complex through cooperative catalysis. Once degraded, the RNA is no more able to induce clustering of the functional monomers, which will come back to the initial random distribution, switching off the catalytic ability of the fibres. Such functional SPs will be then tested in more complex systems, to trigger downstream self-assembly of DNA structures. Finally, liquid-l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Novel pressure relieving and sensing mattress and an intelligent control system that predicts and prevents pressure ulcers in bedridden patients'.

assistant: **Objectives**

ReQbo is developing a disruptive system for preventing pressure ulcers (PU) in bedridden patients by intelligently andcontinuously assessing a personalized risk score for each patient. This system is the first market solution offering activepreventive care, instead of the reactive care that is enabled by competing technologies. Accordingly, the system will becapable of contributing to a steep reduction in PU incidence in long-term care units, both in hospitals and nursing homes.Treating pressure ulcers is very costly, accounting for more than €20 billion per year supported by EU public healthcaresystems. Prevention and early detection are the main priorities to reduce this current healthcare burden. Despiteimprovements in healthcare systems and technologies, patients are still at risk of developing pressure ulcers, because ofineffective and incomplete routine care to assign preventive measures. With current technologies and clinical practices,patients in need of prevention cannot be accurately and reliably detected, which lead to PU development. While thetreatments options are well established once a patient has been diagnosed with high PU-risk, the method for assessing thatrisk has not evolved significantly in 20 years.In order to tackle this challenge, ReQbo has developed and patented its Qone system: a pressure relieving mattress, withintegrated temperature and pressure mapping sensors, that synchronizes data with a highly accurate screening algorithm.This algorithm assesses a PU risk score based on individual patient parameters and a long-term record of how pressure andtemperature have been distributed in the patient’s body, allowing a reduction of approximately 75% on the overall number ofnew pressure ulcers in bedridden patients. The result of each risk score asse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Asymmetric catalysts using three-fold symmetry' under Fifth Framework.

assistant: **Concept**

Young researchers, specialists in their disciplines, will interact in a multidisciplinary project environment. They will learn to work in a multinational team and work in a foreign European country, thus strengthening of professionalism and personality of the young researchers. Technology transfer will be an important issue.- High-throughput experimentation: access to automated equipment for high throughput synthesis and testing; on-line monitoring and analysis; use of high-pressure apparatus.- Modern analytical methods: access to a large number of modern , top-quality analytical apparatus.- Project and time management, communication: planning, coordination and execution of a research project; communication with partners in the project; setting up a web-page as a forum; active participation in international conferences.- Languages and social experiences: official network language English; other European languages; living in a foreign country.