RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Biodiversity of coastal marine ecosystems. A functional approach to coastal marine biodiversity' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The proposed conference is the last of a series of two with the overall objective to inventory, summarise and generalise the scientific knowledge on the structure and function of marine biodiversity in coastal marine areas of Europe. Now that the Rio Convention has been ratified by nearly all European countries, and by the European Union, it becomes clear that the knowledge required to cover the obligations of the convention is simply not available, even in Europe where the seas have been explored for hundreds of years and taxonomic and general ecological knowledge is well advanced when compared to other areas of the world. The first meeting aimed at increasing relevant knowledge by inventorying what is known on three aspects of biodiversity (genes, species, habitat) in shallow coastal areas.The proposed 2nd meeting will build on this and attempts to address some of the questions proposed by it. The emphasis will be on understanding the causes of the observed patterns and on functional studies that try to understand the role of biodiversity in biogeochemical cycles, ecosystem productivity and food web structure. It will bring together the widely separated marine biodiversity research projects that are now underway in many countries as a consequence of the Rio Convention. Emphasis will be on large-scale and long-term problems such as the consequences of climate change. Since we cannot conduct realistic experiments on these scales, this will be achieved by the integration of a number of short-term and regional research projects that are now running, notably in the fifth framework programme of the CEC, that address functional problems (the role of marine biodiversity) and that would benefit enormously from being discussed together. A number of the most important problems i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Use of drones for Emergency management' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Firefighters fatalities are increasing worldwide because they are the first entering in damaged buildings or in fire, without knowing the location of victims and the source of danger. The Principal Investigator has invented a system for indoor tracking that is able to detect victims inside buildings after a disaster (earthquake, fire, etc.) using a radio frequency system (UWB) based on fixed nodes (anchors) in the building to detect the location of wearable nodes (tags).  The application has been patented (PCT application: n. 102016000109493).  The idea of the project IDEAL DRONE is to install the anchors on an unmanned aerial vehicles (UAVs) swarm that is flying around the building.  The UAVs will be equipped with a customized sensor network so the system will provide indoor localization for managing emergencies without the need to install a structural health monitoring system (SHM) inside the building.  Then the health condition and the location of the victims can be plotted in a map, so that rescue operations can be optimized.  The goal of the project is to develop the first prototype of the system using a developing board for rapid prototyping and perform an initial market analysis of the system to analyze the impact of this product in the market. After the first prototype the next step will be to redesign all the electrical parts to find the optimal solution between quality and price for each submodule and component of the system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Artificial Intelligence for Image Data Analysis in the Life Sciences' in the context of a Horizon Europe call.

assistant: **Objectives**

Machine learning (ML) has enabled and accelerated frontier research in the life sciences, but democratised access to such methods is, unfortunately, not a given. Access to necessary hardware and software, knowledge and training, is limited, while methods are typically insufficiently documented and hard to find. Furthermore, even though modern AI-based methods typically generalize well to unseen data, no standard exists to enable sharing and fine-tuning of pretrained models between different analysis tools. Existing user-facing platforms operate entirely independently from each other, often failing to comply with FAIR data and Open Science standards. The field of AI and ML is developing at a staggering pace, making it impossible for the non-specialist to stay up to date.To enable the life science communities to benefit from AI/ML-powered image analysis methods, AI4LIFE will build bridges, providing urgently needed services on the common European research infrastructures. We will build an open, accessible, community-driven repository of FAIR pre-trained AI models and develop services to deliver these models to life scientists, including those without substantial computational expertise. Our direct support and ample training activities will prepare life scientists for responsible use of AI methods, while contributor services and open standards will drive community contributions of new models and interoperability between analysis tools. Open calls and public challenges will provide state-of-the-art solutions to yet unsolved image analysis problems in the life sciences. Our consortium brings together AI/ML researchers, developers of popular open source image analysis tools, providers of European-scale storage and compute services and European life sciences Research Infrastru
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Smart Cardiac Magnetic Resonance Delivering One-Click and Comprehensive Assessment of Cardiovascular Diseases' (SMHEART).

assistant: **Concept**

Cardiovascular disease (CVD) causes at least 1.8 million European deaths annually, exceeding fatalities from cancer, chronic respiratory disease, and diabetes. Consequently, the fight against CVD has become the main priority of the World Health Organization.In the pursuit of understanding and treating CVD, cardiac magnetic resonance imaging (CMR) has remained the only modality capable of providing a comprehensive assessment of the hearts function and structure without harmful radiation. Unfortunately, current CMR systems remain too slow, too complex, require highly trained specialists and, as such, have presented a barrier to a wider adoption of CMR.The aim of my ERC project is to unleash the full potential of CMR to transform patient trajectories by introducing a fast, one-click, fully automated, and comprehensive imaging pipeline applicable to diagnosis, prognosis, and therapy selection in cardiology.This aim will be achieved by (i) creating a novel imaging technology that collects CMR data in a single continuous free-breathing scan, taking into account post-processing requirements at the very origin of CMR sequence design; (ii) exploiting the unique contrasts generated by this technology to automatically extract quantitative markers on cardiac anatomy, function, and tissue characteristics; and (iii) translating this transformative technology from a pre-clinical to a clinical setting.This will be the first-ever integrated cardiac imaging pipeline in which CMR images are acquired in a single click, jointly represented in a single volume, and automatically analysed. This will unlock obstacles for broader acceptance of CMR and unleash the full potential of CMR to maximize its impact on patient trajectories. The results of this project will pave the way towards robust ima
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'International Network for Training on Risks of vascular Intimal Calcification And roads to Regression of cardiovascular diseasE' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Cardiovascular disease remains one of the major challenges of contemporary society, being responsible for a staggering 47% of deaths in Europe. Vascular calcification in particular requires immediate attention as it is strongly associated with increased cardiovascular mortality and morbidity, and is recognised as an important independent risk factor for cardiovascular death. Recent reports demonstrate that especially punctuated and spotty calcifications (microcalcifications) in the plaque are life-threatening. Microcalcifications are particularly prominent in the vulnerable atherosclerotic plaque that is at high risk of rupture, a cardinal event that can cause thrombosis, infarct, cardiac arrest, stroke and death. In fact, 20% of European deaths are directly attributable to thrombotic rupture of a vulnerable plaque; a clear indication that current treatments and preventive measures are insufficient. Recent findings suggest a link between vascular smooth muscle cell phenotype mediated calcification and inflammation, which could underlie the plaque destabilising effects of microcalcification. However, a comprehensive view on what causes microcalcification and its impact on plaque stability remains elusive and there is an urgent need to translate experimental findings into adequate diagnostic, preventive and therapeutic solutions. INTRICARE is shaped to address the urgent unmet medical needs concerning calcification-induced vulnerable plaques and is guided by the academic and industrial demand for a new generation of entrepreneurial scientists that have the skills, expertise and knowhow to expedite our understanding of vascular calcification and translation thereof into concrete, effective clinical solutions. The INTRICARE ESRs harbour ongoing vitamin K-supplementation tri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Modelling pollutant transfer through arctic marine food webs', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The main objective of the project is to modify and parameterize a model based on Campfens and MacKay (1997) to describe the pollutant transfer process through Arctic marine food webs including seabirds and seals as top predators. This will be an important contribution both to the understanding of pollutant accumulation in food webs in general, and in marine northern environments particular, since the model will be expanded to be valid for marine high-latitudinal food webs with warm-blooded animals as top predators. Preliminary studies by the applicant have described organochlorine concentrations and patterns in the food web, resulting in a detailed and extensive data set that can be utilized to model quantitatively the food web pollution transfer in order to identify which parameters are important for the bioaccumulation process.The objectives are:- To modify a model describing food web organochlorine accumulation validated for a temperate lake food web to be valid for Arctic marine food webs- To expand the existing model to include seabirds and seals rather than fish as top predators in the food web- To identify the parameters in European Arctic marine food webs that are important for the organochlorine accumulation:* Is the influence of lipids important?* Is the food web structure and food chain length important?* Does a diet of ice-associated fauna as opposed to pelagic fauna influence the biomagnification in top-predators? The applicant expects to develop quantitative analytical skills during the training, which will consist in the set up of mass balance equations to describe food chain pollutant transfer and the following conversion of the mathematical relationships with programming language techniques. The applicant will also benefit from being in a new scientific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'MOLECULAR DETERMINANTS OF THE REGULATION OF LXR ALPHA TRANSCRIPTIONAL ACTIVITY BY ACETYLATION IN MACROPHAGES' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Liver X receptors (LXRs) alpha (a) and beta are nuclear receptors that act as metabolic sensors for cellular cholesterol. LXR agonists increase HDL cholesterol levels, have anti-inflammatory properties and improve insulin sensitivity. Therefore LXRs are now considered promising drug development targets for the management of human metabolic diseases. The search for LXR ligands void of their deleterious hyper-triglyceridemic actions has been traditionally based on their effects on receptor binding. We propose, as an alternative strategy, that regulation of post-translational modifications of LXR could be employed. My previous studies reveal that modulation of post-translational modifications of the receptor, such as phosphorylation, regulate LXRa actions in a gene-specific manner. Our preliminary studies indicate that, in addition to phosphorylation, LXRa is subject to acetylation and that treatment with trichostatin A (TSA), an inhibitor of histone deacetylases, affects LXRa protein concentration. Thus we hypothesize that acetylation of the receptor could also affect the activity of LXRa in macrophages in a gene-selective fashion. In this proposal our main goals will be to: 1) Investigate the influence of LXRa acetylation on LXRa transcriptional activity and determine the mechanisms involved, 2) Elucidate the impact of phosphorylation and acetylation on LXRa protein stability, 3) Determine the crosstalk between phophorylation and acetylation of LXRa and 4) Identify and functionally characterize LXRa phosphorylation– and acetylation-modulated protein complexes employing a proteomic approach. In light of the pivotal role LXRa plays in cholesterol metabolism, identifying the role of acetylation in LXRa activity and the TSA-sensitive signaling pathways that acetylate LXRa is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Crossing the Atlantic. Diocesan Agents of the Viceroyalty of Peru in Rome (XVI-XVII century)' (Procuradores).

assistant: **Innovation**

The proposal aims at conducting a historical investigation of human mobility in local and global contexts through the case study ofreligious agents (the procuradores) that moved across the Atlantic from the ecclesiastic province of Lima to the Holy See to representtheir communities’ political and religious interests. Atop of a growing body of secondary sources and thanks to a multinational andmulti-archival investigation (Chile, Peru, Spain, Vatican, Rome), the research brings together several disciplines – history, geography,social sciences, and law studies, in dialogue with Atlantic studies and the network analysis, in order to develop three original aims.First, it will offer a new understanding of the relationship among the Spanish Crown, the Holy See and the Viceroyalty of Peru. Theresearch will investigate who the procuradores of the cathedrals were. The proposal aims at identifying both the secular and religiousprocuradores who crossed the Atlantic, traveling from the dioceses to Rome. It will identify their social, institutional, political and,eventually, religious belonging and affiliation. I will study the type of information the procuradores transmitted to the Holy See andhow it was used to build the networks of political and religious relations with the Spanish Monarchy. Once the procuradores havebeen identified, it will be possible to analyse the information that reached Rome from the Viceroy of Peru (and those that did not), itsprocessing in the Curia, its use in the government of the Church, and its use in political and diplomatic relations with the SpanishMonarchy. I will study how the procuradores interacted with the city of Rome.The project will be implemented in 3 different institutions: Pontificia Universidad Cattolica de Chile (outgoing phase), Unive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Management of object oriented distributed development systems' (MOODS).

assistant: **Concept**

OPENLAKE is a distributed software factory, with sites spread all over Italy and connected with phone lines and Internet links. Project management and quality assurance, are centralised, developers are distributed. This distributed organisation is not, today, completely successful, causing a waste of time and resources. On the other hand very limited industrial experience and practice is available about distributed software processes. This PIE aims to experiment a methodology and tools to establish efficient communication and work procedures among physically distant groups and improve this situation.THE EXPERIMENTThe project will introduce a methodology for efficient production of software products in a wide area distributed environment, repeating the following steps:definition of the distributed production processdefinition of procedures and organisation for the distributed production processsurvey, evaluation and experimentation of supporting toolsThe main issues to be addressed with the above methodology are:type and quantity of information to communicate to distributed developers for coding and unit test, allocation to developers of coding/testing unitsdefinition and allocation of stub classes for test, definition and management of a stub class repositorydistributed project trackingEXPECTED IMPACT AND EXPERIENCEThe experiment will be considered successful if it will: improve communication and co-ordination among distributed developers; discipline frequency and type of interaction between developersreduce frequency and duration of meetings (therefore reduce cost of travel and subsistence)reduce the need of relocating personnel (therefore reduce cost of relocation )improve tractability (where and at which development stage is each distributed component) improve integr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Probing the Fate of Stem Cells through the Development of a Multiplex Coherent Anti-Stokes Raman Scattering Imaging Technique' (CARSforSTEM).

assistant: **Concept**

Stem cell science and technology hold a great deal of promise within the context of tissue repair and regeneration. Whilst we know a lot about the function and response of stem cells in the laboratory, we know very little about their behaviour in tissues within individuals, delaying their applicability to the clinics. A major barrier has been the inability to accurately track cell lineages and to distinguish them from other cell types within the tissue. Fundamental questions, i.e. when one cell divides to become two cells are they the same or different? is this effect the same or different each time the cell divides?, have not been answered yet. The proposed project will address these issues by developing microscopic techniques that allow us to image these cells in a non-invasive, non-harmful way (unlike current approaches) and we will utilise technologies that will eventually enable us to track these cells deep within patient tissues. Coherent Anti-Stokes Raman Scattering (CARS) has recently emerged as a new multiphoton microscopy technique which directly addresses endogenous biomolecules with high chemical specificity without the need for exogenous labelling. This imaging technology would be ideal to follow non-invasively, living stem cells during differentiation in real time at physiological conditions without any of the artefacts/problems associated with labelling. We will use different modalities to identify endogenous markers of stem cell differentiation for tracking purposes. First, CARS and Differential CARS will be used to examine the lipid distributions within stem cells undergoing differentiation. Furthermore, to improve the chemical specificity we will develop a novel Coherent Multiplex CARS method to address a large number of vibrational frequencies simulta