RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development and application of standardized methodology for the PROspective SUstaInability assessment of TEchnologies' (PROSUITE), addressing dissemination and exploitation.

assistant: **Impact**

The main goal of PROSUITE is to develop a framework methodology, operational methods and tools for the sustainability assessment of current and future technologies over their life cycle, applicable to different stages of maturity. The project will apply the methodology for four technology cases with close consultation of the stakeholders involved, which includes cases from biorefineries, nanotechnology, information technologies, and carbon storage and sequestration. PROSUITE will show (i) how to combine technology forecasting methods with life cycle approaches, and (ii) how to develop and possibly combine the economic, environmental and social sustainability dimensions in a standardized, comprehensive, and broadly accepted way. PROSUITE will create a solid research basis for technology characterization, including the identification of decisive technology features, basic engineering modules for estimations of material flows and energy use, and learning curves. For the economic assessment, methods for the assessment for economic and sectoral impacts of novel technologies will be developed and combined with background data for scenario-based life-cycle inventory modelling. For the environmental assessment, state-of-the-art environment indicators will be proposed together with targeted method development for the assessment of geographically explicit land and water use impacts, metal toxicity and outdoor nanoparticle exposure. For the social assessment, a set of quantitative and qualitative social indicators will be selected via participatory approaches, setting the standard for future assessments. The use of various multicriteria assessment methods will be explored to aggegrate across indicators. The methods developed will be part of a decision support system, which will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Super resolution imaging of nanoPMOs for cancer drug delivery' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In recent years, nanomaterial-based various drug delivery carriers have been developed for the potential targeted cancer therapy. However, still the advanced study for optimization of size, shape, surface chemistry of the nanocarrier and observation of biological interaction and evaluation of such nanocarrier are not well-developed that limit their use for the efficient clinical applications. Therefore, superior understandings of the cellular interaction of the nanocarrier with different physicochemical properties are essential and challenging for improved the cancer treatments. In this project, we will focus on the optimization of different physicochemical properties of nanocarrier such as size, shape, surface chemistry and etc via investigation of its biological interaction and evaluation by a potent imaging technique. For this purpose, we will synthesize a library of efficient biodegradable drug delivery carrier periodic mesoporous organosilica nanoparticles (nanoPMOs) withcontrolled size and shape and then functionalized with different targeting ligands with the controlled number per nanoparticle for mannose-6-phosphate receptor over-expressed prostate cancer. Then we will study the nanoPMOs-prostate cancer cell interactions, internalization pathway and intracellular degradation of nanoPMOs through the stochastic optical reconstruction microscopy (STORM). We will further evaluate the drug delivery efficacy of nanoPMOs and toxicity mechanism of drug loaded nanoPMOs to support microscopic observation. Thus the result of this biological interaction and evaluation of nanoPMOs with different physicochemical properties via super-resolution microscope STORM will help to develop a novel drug delivery carrier for prostate cancer therapy with optimal properties for clinical a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Robust Speech Encoding in Impaired Hearing' (RobSpear).

assistant: **Innovation**

The prevalence of hearing impairment amongst the elderly is a stunning 33%, while the younger generation is sensitive to noise-induced hearing loss through increasingly loud urban life and lifestyle. Yet, hearing impairment is inadequately diagnosed and treated because we fail to understand how the components that constitute a hearing loss impact robust speech encoding. A recent and ground-breaking discovery in animal physiology demonstrated the existence of a noise-induced hearing deficit -cochlear neuropathy- that coexists with the well-studied cochlear gain loss deficit known to degrade the audibility of sound. Cochlear neuropathy is thought to impact robust encoding of the audible portions of speech and occurs before standard hearing screening methods indicate problems, implying that a large group of noise-exposed people with self-reported hearing problems is currently not screened, nor treated. To design effective hearing restoration strategies, it is crucial to understand how cochlear neuropathy interacts with other hearing deficits to affect robust speech encoding in every-day listening conditions. Through an interdisciplinary approach, RobSpear targets hearing deficits along the ascending stages of the auditory pathway to revolutionize how hearing impairment is diagnosed and treated. RobSpear can yield immense reductions of health care costs through effective treatment of currently misdiagnosed patients and studies the impact of noise-induced hearing deficits on our society. To achieve this, RobSpear: (i) Builds a hearing profile that, based on a computational model of the auditory periphery, develops physiological measures that differentially diagnose hearing deficits in listeners with mixtures of deficits.(ii) Designs individually tailored speech enhancement a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Programme on the recyclability of food packaging materials with respect to food safety considerations-polyethylene terephthalate and cellulosic fibres' (RECYCLABILITY) targeting Fourth Framework.

assistant: **Abstract**

Food packaging regulations in Europe require that the packaging materials must n ot cause mass transfer (migration) of harmful substances to the food. Considerab le scientific progress has been made in understanding and modelling the transfer of adventitious hazardous substances from recycled plastics into foodstuffs. Mo st of this knowledge has been elaborated within the recently finished EU project AIR-CT931014. One of the main conclusions of this project was that PET as a low diffusivity plastic and is the most promising polymer for reuse as a food packa ging material. Nevertheless, the practical translation of this progress into inn ovative industrial solutions is still awaited. One of the reasons has typical 'E uropean' character and can be substantiated by the fact that the European legal requirements in this respect are not yet clearly and uniformly defined. As a con sequence, economic and generally recognized test methods are not available so fa r. With respect to PET, there is clearly an obvious reason for the industrial he sitation in launching advanced food packaging applications. In the whole chain o f knowledge on diffusion and migration into and out of PET - which allows for in stance to correlate a known initial concentration in the plastic with the result ing time-dependent concentration in a foodstuff - there remains one missing link : This is the still open but highly important question of the nature and concent ration of actual contaminants found in re-collected PET. Filling up this gap wit h analytical data relevant for the whole of Europe, and then linking this statis tical picture with the available knowledge on PET diffusion behaviour, would ena ble to draw scientifically sound and convincing conclusions about the safety of reusing PET. With respe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Electrical line for competitive and full compatible household goods, communications and utility equipment' to be submitted under Fourth Framework.

assistant: **Abstract**

To define and implement the functional and architectural specifications for the products that will be developed within the project (intelligent sockets, intelligent thermostats, energy meter gateway, interactive TV terminal, CATV gateway).To define the interoperability profiles for load management and electro-appliances.To optimise the existing telephone gateway, energy controller and remote configurator to allow full energy control and the reception of data files.To develop new products: electric store heater, water heater, intelligent thermostat and intelligent socket.To test and verify user acceptance in a real environment of the following functionalities: energy management, remote configuration, control and monitoring of the electro-appliances, user interface and external communications.Products are to be developed with integrated EHS (European Home System) interfaces using the power line as a medium for the data transfer. These products will be configured and installed in two demo sites, one in Spain and one in Italy. The focus is to optimise the energy and load management as well as the comfort. For the first one an interface between utilities and the customer is developed to allow the utility to offer new services to the customer. In the second, a homogenous interactive television set-top box enables the client to configure his own system in a very user-friendly way. Additional communication products like PSTN gateways and CATV gateways will also permit a remote configuration and monitoring of the EHS functions by any external service provider.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Participation of boundedly rational agents in financial markets - effects on speculation, trading volume and price volatility' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Empirical work has provided evidence that many economic agents who have to make decisions under pressure are not fully rational. My research deals with financial markets in which there are agents who are boundedly rational. First, I will study markets in which there are both fully rational and boundedly rational agents and focus on implications of boundedly rational agents' behavior on rational speculators' trading strategies and so on trading volume and price volatility. Secondly, I want to test if, when trading, professional speculators use alternative decision making theories and more particularly Prospect Theory. Part of this theory says that agents make decisions with respect to a reference point, are risk averse in gains and risk lovers in losses with respect to their reference point. I want to study option markets since the risks undertaken can be easily measured. Comparisons between countries and underlying assets (stock and futures) are also planned.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Carbohydrate utilization by the working muscle of rainbow trout' (2007-2013).

assistant: **Concept**

Carbohydrate-rich diets are frequently used in the commercial farming of fish. However, fish do not appear to have an elevated capacity to clear a high load of glucose from their circulation. Special attention has been directed towards the study of the physiological responses to such carbohydrate-rich feeding. Skeletal muscles play a key role in glucose homeostasis in mammals, and exercise has a noticeable effect in lowering plasma glucose. This effect is caused by an up-regulation of glucose transport mediated by GLUT4 in skeletal muscles in response to exercise. However, the exact mediating mechanism in the modulation of glucose transport in skeletal muscle has not been entirely characterized in vertebrates. Moreover, fish are an excellent model for the research of mechanisms involved in changes of the GLUT glucose transporters produced by exercise because they have anatomically separated red and white muscle masses, which allow the measurement of fibre-type-specific responses. I hypothesize that sustained exercise can be used to enhance carbohydrate expenditure in fish, increasing their natural capacity to clear and utilize plasma glucose by the contracting muscle. I will investigate this possibility, placing a special emphasis on the study of the cellular and molecular mechanisms regulating the GLUT-1 and -4 glucose transporters in white and red muscles. Changes in patterns for gene expression using a microarray platform and key biochemical parameters will also be measured in red and white muscles of rainbow trout after four weeks of sustained swimming. I expect that the results obtained from this research will help us to understand how glucose is regulated in fish. This knowledge could be transferred to European companies, leading to more efficient and environmenta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'From wild to crop: unravelling the impact of root domestication on drought tolerance'.

assistant: **Objectives**

Crop domestication revolutionised human life. This process induced changes in plant traits that produced plants that grew faster and generated higher yields. However, remarkably little is known about how plant roots have changed throughout the domestication process. Climate change is causing increasing droughts in many parts of the world. Given that roots are the way that water enters the plant, they are key for understanding drought tolerance. Root traits from crop ancestors could offer a route to increasing drought tolerance of modern crops. To do this, we need to focus our efforts on the impact of domestication on roots and the rhizosphere (the zone around the root including microbes), rather than only aboveground traits as traditionally done. WILD-ROOTS will therefore test the overall hypothesis that crop domestication led to changes in root and rhizosphere traits which decreased the drought tolerance of crops compared to their wild relatives. WILD-ROOTS will make a holistic study of the roots and rhizospheres of a wide range of crops from diverse origins. There will be a focus on root exudation and volatile organic compound (VOC) emission, which are vital root processes that are crucial for many types of interactions with plants, animals, microbes and the soil itself. Changes in root exudates and VOCs have been observed during drought conditions, but their roles in the drought tolerance of plants remains unclear. WILD-ROOTS will (1) evaluate domestication effects on the roots and rhizosphere, then (2) elucidate the mechanisms relating belowground traits to drought tolerance, and finally (3) use this knowledge to modernise crop models and identify belowground traits to be exploited for drought-proofing current crops. The results will reshape our fundamental knowledg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular Characterisation of the INTRAcellular Plant Aquaporin Trafficking and Hetero-oligomerisation' (2007-2013).

assistant: **Innovation**

In plants, the movement of water and small neutral solutes across the plasma membrane (PM) is dependent on the number and activity of water channels, named aquaporins (AQP). Little is known about mechanisms by which AQPs reach their final destination. Recent studies have shown that PIP (Plasma membrane Intrinsic Protein) aquaporins belonging to two subgroups, PIP1 and PIP2, physically interact to regulate their trafficking and the cell membrane water permeability. Therefore, this mechanism might play a pivotal role for the regulation of PIP functions. The main objective of the project is to generate detailed knowledge about the mechanisms regulating the intracellular trafficking of PIP1 and PIP2 aquaporins and the implication of their mutual interaction. To achieve this goal, 4 work packages have been defined. 1) We will characterise protein motifs responsible for ER retention of PIP1s and PM trafficking of PIP2s. 2) The amino acid residues responsible for the physical interaction between PIP1 and PIP2 isoforms will be determined. 3) We will investigate the transport capacity and selectivity of PIP hetero-oligomers. 4) Mechanisms governing subcellular PIP redistribution and dynamics upon specific stimuli will be characterised. The project represents a fundamental scientific approach providing valuable insights into hetero-oligomer formation, sorting and spatial redistribution of PIPs and will clearly advance the “state of the art” of the plant AQP research. It will generate a highly relevant basis for the uncovering of specific AQP functions in cells, tissues and thus in the metabolism of plants. Furthermore, these data will be crucial for the use of AQPs in biotechnological or plant breeding strategies aiming at a modulated water or solute transport leading to a higher
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Functionally graded Additive Manufacturing scaffolds by hybrid manufacturing' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Additive Manufacturing (AM) market has grown with trends higher than 20% every year in the last 10 years. Their fast uptake is due to different innovative factors such as no shape limits in manufacturing process, full customisation on the single artefact, localised production and no waste material. In particular the ability to print any shape allows to design the products not following the constricting conventional manufacturing processes but just focalising on their function. This “Design for Function” feature is one of the main drivers for AM uptake on a wider scale production and the limited number of “functional” materials that can be printed or the limit in controlling gradient and surface properties are showing to be an important barrier. This is particularly true in manufacturing of tissue engineering (TE) scaffolds where the technology has a promising growth over the last decade. Scaffolds production for tissue regeneration is one of the main fields where the “Design for Function” feature of AM make the difference relative to the other production techniques if in the production process all the needed “Functions” can be introduced: mechanics, geometry (porosity and shape), biomaterial, bio-active molecules and surface chemical groups.The FAST project aims to integrate all these “Functions” in the single AM process.This integration will be obtained by the hybridisation of the 3D polymer printing with melt compounding of nanocomposites with bio-functionalised fillers directly in the printing head and atmospheric plasma technologies during the printing process itself. Final objective of the project is to realize a demonstrator of the proposed hybrid AM technology in order to achieve a small pilot production of scaffolds for bone regeneration with the novel smart fea