RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'In-situ spatiotemporal imaging of membrane hydration, electrostatics, tension and curvature to understand cell response to osmotic shocks and cell migration.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Lipid membranes compartmentalize and protect cells from the environment, and selectively permit transport. This functionality derives from unique membrane properties: 5 nm thick, yet fluid, deformable, resistant to stress and chemically complex. The physicochemical properties of membranes are expected to have a major impact on cell life, but the tools to measure the relevant multiscale and dynamic parameters in-vitro and, more importantly, in-vivo membranes are lacking. An essential property of membranes, their hydration and charge state, both needed for membrane integrity and playing a vital role in cell survival is not understood beyond the level of continuum theory. To enable quantitative physics, and physical chemistry for biology Roux and Roke, R^2, will join their expertise on molecular biology & biophysics and physics & interfacial chemistry & optics to create tools to measure membrane water and ion fluxes, and image 3D fields of electrostatic free energy, membrane tension and curvature. We will understand how molecular factors, such as the influence of the aqueous phase and interfacial electrostatics, are coupled to tension and curvature under dynamic conditions such as osmosis in artificial and cellular membranes. Obtaining the first temporally resolved, 3D maps of hydration, free energy, tension and curvature at the nanoscale in migrating cells and cells experiencing osmotic shocks we will quantify membrane physical parameters in two processes essential for cell survival, for which currently no data is available: Osmotic shock response and cell migration. Osmotic shock response plays an important role in infections, kidney and intestine function. Cell migration is essential to many cell processes, for example the spreading of cancer, wound repair and the immun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Biomarker and AI-supported FX06 therapy to prevent progression from mild and moderate to severe stages of COVID-19' (COVend) under Horizon Europe.

assistant: **Objectives**

More than 2.7 million hospitalisations of COVID-19-infected patients have occurred in Europe alone since the outbreak of the coronavirus in 2020. An average 14% of those patients with mild or moderate illness develop severe symptoms and are eventually admitted to the Intensive Care Unit (ICU). The most common treatment of patients in the first two stages of the illness, such as remdesivir and antibody therapies, have neither shown the desired effect nor prevented the progression of the disease to severe and critical stages of the illness. Interventions against SARS-CoV-2 are in high need to prevent admissions to ICUs, and would reduce the burden on patients and their families, clinical staff and the healthcare sector. Additionally, such interventions would help to provide ICU beds for non-Covid patients requiring immediate interventions, such as for heart or cancer surgery, both of which are often in need of planned free ICU beds.  In COVend, our multidsciplinary consortium will deliver a new effective therapy against SARS-CoV-2 for the clinical management of the COVID-19 disease during mild and moderate stages, including for the prevention of disease progression to severe illness. This will be achieved by advancing a promising therapeutic candidate, FX06, from Technology Readiness Level (TRL) 7 to TRL9 through a multi-centre phase II/III clinical trial. COVend will study the influence of COVID-19 on endothelial cells (ECs) and the potential protective effect of FX06, and will apply -omics technologies, generate new algorithms and open-source software to carry out data analytics and modelling, and will develop health economic models to assess the socio-economic benefits and cost effectiveness of the new therapy. The COVend consortium unites expertise from different disc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Control of Intracellular Calcium in Arrhythmias' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Ventricular arrhythmias are a major cause of mortality. Currently there is no effective treatment available, largely because our understanding of their molecular basis is poor. Altered intracellular Ca handling may be a final common pathway predisposing to ventricular tachycardias and sudden death in acquired or congenital heart diseases. In particular, dysfunction of the SR Ca release channel (ryanodine receptor, RyR2) has been implicated in arrhythmogenesis and sudden death in heart failure and in catecholaminergic polymorphic ventricular tachycardia (CPVT), a fatal inherited arrhythmogenic disease characterised by mutations in RyR2. Understanding the complex function of the RyR2 Ca channel and its regulatory mechanisms, therefore, holds the promise to develop new diagnostic and therapeutic strategies for effective treatment of these lethal arrhythmias. The CONTICA investigators are a multidisciplinary team composed of cardiologists, molecular biologists, biophysicists and physiologists with established and complementary interests & expertise in the study of intracellular Ca handling and arrhythmias.The goal pursued by the CONTICA group is the elucidation of the molecular mechanisms linking defective RyR2 funcion to the generation of arrhythmias. Employing a wide range of state-of-the-art techniques, the group will perform in depth studies on RyR dysfunction in animal and human arrhythmias on the molecular, cellular and whole organism level. Of particular importance, data gathered from the world's largest collective of individuals affected by mutations in RyR2 will reveal novel insights into the genetics of CPVT and enable genotype-phenotype correlations and expression studies of mutated RyR2 in cell lines & animals. The combined knowledge gained from these studies wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exchange of Excellence in Ubiquitous Computing Technologies to Address Healthcare Challenges' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Pervasive Healthcare is focused on working out how to cope with the next generation challenges in healthcare. Addressing these challenges will require expertise and knowledge exchange with countries beyond European borders as well as training of the next generation of researchers in order to gain the expertise necessary to be able to address the upcoming challenges. Moreover, research on Pervasive Healthcare has been conducted in several areas, ranging from assisting independent living at home, supporting hospital staff, promotion healthy habits, or providing care to for people with special needs. Each of the members of the consortium has worked in one or more of these areas and they will bring this expertise to the Consortium in terms of multi-disciplinary, methodological and technical approaches.The UBI-HEALTH program will create a stimulating research exchange foundation that will equip students from different continents with expertise in Pervasive Healthcare. The knowledge of requirements and available technologies for healthcare will be shared and become complementary between students, researchers and host institutions from Europe and the associated third countries including Mexico, Chile, China and USA (this last not funded by EU). This will allow students to put this knowledge in use in their own context, improving healthcare provisioning and impacting on both preventative medicine and alternative means of treatment.In summary, the main focus of the exchange program is in one hand to consolidate the Pervasive Health domain by interaction of Experienced Researchers in identification of challenges, setting of roadmaps and production of relevant didactic materials such as a course syllabus and textbook in the topic and to enable new generation of researchers to adap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'On farm assessment of stress level in fish' (FASTFISH).

assistant: **Concept**

The main goal is to develop the first database and expert system for on farm welfare and stress level assessment in farmed fish in all ontogenetic stages (FAST-TOOL). This will include validated non-invasive behavioural and chemical stress level indicator s that can be used to monitor and quantify acute and chronic stress levels.The main focus areas for potential indicators will be feeding motivation and individual and group swimming behaviour. Feeding motivation depends on the metabolic state of the fish and is well known to be sensitive to stress, and can be assessed by e.g. quantifying anticipatory behaviour before feeding or feed intake.Secondly, swimming behaviour is an indicator of behaviour control level, and should be sensitive to stress level and physiological state. Our hypothesis is that under increasing stress an individual will change from individual goal directed behaviour to group controlled behaviour, and finally loose behavioural control.The identified indicators will be cross-validated as proxy measures for stress using immunological and physiological methods. To interpret these indicators correctly and identify the stressors, essential information on present and previous rearing conditions must be available.This will be achieved by the database and expert system, which also will give early warning when rearing conditions or stress level indicators approach harmful conditions. The expert systems will also include forecasts based on artificial neural networks.FASTFISH will use European sea bass and Atlantic salmon as model species and tailor the FAST-TOOL to commercial production by testing on selected hatcheries and farms in periods with potentially high and low stress levels.Finally, FASTFISH will evaluate what market-factors and governance mechanisms
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Minimal Systems for Spatiotemporal Control of Gene Expression as Self-manufacturing Gene Therapeutics' in the context of a Horizon Europe call.

assistant: **Objectives**

The development of effective gene therapies is hindered by limitations in current delivery methods, such as the use of lipid nanoparticles (LNPs) and extracellular vesicles (EVs).  We propose a novel approach to overcome these limitations by constructing a self-organizing minimal system capable of producing therapeutic mRNA. Our system leverages the power of lipid membrane compartments to control and regulate gene expression, mimicking the sophisticated spatiotemporal control found in living cells.  Our research will focus on three main objectives: (1) investigating the activity of transcriptional and translational machinery in the proximity of lipid membranes, (2) designing and constructing a minimal system that exhibits spatiotemporal self-organization of gene expression, and (3) developing self-manufacturing platforms for the delivery and development of gene therapeutics.  By combining expertise in chemistry, biology, physics, and engineering, we aim to create a highly reproducible and efficient system for producing therapeutic mRNA. This will pave the way for the development of safer, more targeted, and more effective gene therapies, ultimately revolutionizing the treatment of various diseases.


**Keywords:** Synthetic biology, Bottom-up construction of cells, Lipid membrane, Vesicles, mRNA, Gene expression
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Dynamics of the Quark-Gluon Plasma: A Journey into new phases of the Strong Interaction'.

assistant: **Concept**

The study of the fundamental theory of the strong interaction, Quantum Chromo Dynamics (QCD), under extreme conditions of temperature and density has captured an increasing interest due to its very rich dynamical content and its relation to the Early Universe physics. Heavy-Ion Collisions (HIC) at ultra-relativistic energy (above ~10 AGeV) provide the possibility to scrutiny the QCD phase diagram reaching energy densities high enough to cause a phase transition of the hadronic matter into a quark-gluon plasma (QGP). The experiments conducted at the Brookhaven National Laboratory have shown that such a state of matter behaves like a nearly  perfect fluid  with a very small shear viscosity, a very high opacity at high transverse momentum pT (>6 GeV) and manifesting evidences for a modification of the hadronization process at intermediate pT (2-6 GeV) . Interestingly and surprisingly enough, also in the heavy quark sector there are hints that viscosity is similarly small. Furthermore some evidence of a new phase of QCD, the color glass condensate (CGC), has been found while its relevance should increase in the upcoming LHC program at CERN. These are the main physics subjects that we deal with in our project.The main objective of the project is to determine the value of the shear viscosity to entropy ratio h/s of the  perfect fluid   and the implications of a possible primordial CGC phase on the dynamical evolution of the system. The research gains strength from a comprehensive study of the rich phenomenology including both inclusive and more exclusive observables (like the two-three particles correlations triggered by hadronic jets) and from the inclusion of hadronization effects. In addition the study will be conducted considering also the heavy flavor sector where a flui
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Giving Beekeeping Guidance by cOmputatiOnal-assisted Decision making' (B-GOOD).

assistant: **Concept**

A key to healthy beekeeping is the Health Status Index (HIS) inspired by EFSA’s Healthy-B toolbox which we will make fully operational, with the active collaboration of beekeepers, by facilitating the coordinated and harmonised flow of data from various sources and by testing and validating each component thoroughly. We envisage a step-by-step expansion of participating apiaries, and will eventually cover all EU biogeographic regions. The key to a sustainable beekeeping is a better understanding of its socio-economics, particularly within local value chains, its relationship with bee health and the human-ecosystem equilibrium of the beekeeping sector and to implement these insights into the data processing and decision making. We will fully integrate socio-economic analyses, identify viable business models tailored to different contexts for European beekeeping and determine the carrying capacity of the landscape. In close cooperation with the EU Bee Partnership, an EU-wide bee health and management data platform and affiliated project website will be created to enable sharing of knowledge and learning between scientists and stakeholders within and outside the consortium. We will utilise and further expand the classification of the open source IT-application for digital beekeeping, BEEP, to streamline the flow of data related to beekeeping management, the beehive and its environment (landscape, agricultural practices, weather and climate) from various sources. The dynamic bee health and management data platform will allow us to identify correlative relationships among factors impacting the HSI, assess the risk of emerging pests and predators, and enable beekeepers to develop adaptive management strategies that account for local and EU-wide issues. Reinforcing and establi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'NEUro cerebellar recurrent network for motor SEQuence learning in neuroroBOTics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The new generation of compliant robots, designed to safely interact with humans in unstructured environments, require control systems able to naturally deal with their “biological features”. These robots can be efficiently controlled using biologically inspired control systems based on brain regions such as the cerebellum. This nucleus plays a key role in fluent body movements, being essential for adaptive motor control and coordination of body movements. The cerebellum was traditionally modelled as a feedforward network with two inputs and one output. Nevertheless, recent experimental studies have demonstrated the existence of multiple recurrent connections in the cerebellum: 1) nucleo-cortical connections (NCCs), and 2) nucleo-olivary connections (NOCs). These recurrent connections back-propagate the cerebellar output activity to the cerebellar inputs, thus shifting the feedforward toward a recurrent approach. NEUSEQBOT project will focus on the NCCs, studying how they contribute to the motor sequence learning capabilities in the cerebellum. This multidisciplinary study will combine neuroscientific experiments in animals, cerebellar modelling and neurorobotic applications. Firstly, we will experimentally study the NCC effect in the cerebellar dynamics during reflexive eyelid movements in optogenetically modified mice. The experimental results will be used to model a recurrent cerebellum. Finally, this cerebellar model will be tested in a neurorobotic object manipulation task using a compliant robotic arm. Within the objectives of H2020, NEUSEQBOT project aims to advance our understanding of how the cerebellum (as a recurrent network) processes the sensorimotor information to generate the required motor command sequences, applying this knowledge to develop biologically
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'InterCONnected NEXt-Generation Immersive IoT Platform of Crime and Terrorism DetectiON, PredictiON, InvestigatiON, and PreventiON Services' (CONNEXIONs) targeting Horizon 2020.

assistant: **Abstract**

CONNEXIONs aims to develop and demonstrate next-generation detection, prediction, prevention, and investigation services. These services will be based on multidimensional integration and correlation of heterogeneous multimodal data, and delivery of pertinent information to various stakeholders in an interactive manner tailored to their needs, through augmented and virtual reality environments. The CONNEXIONs solution encompasses the entire lifecycle of law enforcement operations including: a) pre-occurrence crime prediction and preventionb) during-occurrence LEA operationsc) post-occurrence investigation, and crime-scene simulation and 3D reconstruction. CONNEXIONs will meaningfully enhance operational and (near) real-time situational awareness, through automated identification, interpretation, fusion and correlation of multiple heterogeneous big data sources, as well as their delivery via immersive solutions. Such multimodal data include Surface/Deep/Dark Web and social media content in 7 languages (EN, FR, DE, PT, RO, ES, AR), data acquired by Internet of Things (IoT) devices, and digital evidence. CONNEXIONs will also provide chain-of-custody and path-to-court for digital evidence. The Project will adopt ethics and privacy by-design principles and will be customisable to the legislation of each member state. CONNEXIONs will be validated in field tests and demonstrations in 3 operational use cases: a) counter-terrorism security in large scale public eventsb) human trafficking investigations and mitigationc) crime investigation and training through 3D scene reconstruction. Extensive training of LEAs' personnel, hands-on experience, joint exercises, and training material will boost the uptake of CONNEXIONs tools and technologies. With a Consortium of 8 LEAs from 7 Europ