RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Eradication of tumors by targeting dsRNA selectively to cancer cells and recruitment of the innate immune system' in the context of a Seventh Framework call.

assistant: **Objectives**

We have recently shown that EGFR over-expressing tumors can be eradicated by an EGFR homing chemical vector, carrying dsRNA. The vector is PolyInosine/Cytosine (PolyIC) bound to Polyethleneimine-Polyethyleneglycol-EGF (PEI-PEG-EGF, PPE). We have shown that even tumors in which up to 50% of cells do not express EGFR are eradicated, due to the strong tumor-localized bystander effects, which involve the innate immune system. Using this EGFR homing vector we have been able to eradicate EGFR overexpressing tumors by either local or systemic application. Since the success of this strategy seems to be due to the strong bystander effects induced by the internalized PolyIC it is likely that heterogeneous tumors, in which only a portion of the cells harbor the targeted receptor, will be eradicated too, as shown in our preliminary studies (PloS Med, 2006). This strategy actually targets the innate immune system to the tumor. We propose to establish tumors in which decreasing portions of cells over-express EGFR and determine the lowest number of EGFR over-expressing cells that can yield tumor eradication by the lowest dose of PolyIC/PPE. The principle behind the success of the Trojan horse approach is that the targeting moiety, EGF, is tethered to the other components of the vector in such a way that it retains its native EGFR binding properties and its ability to internalize with the receptor. The composition of the vector is such that the ligand EGF can be replaced by any other ligand, if the appropriate coupling conditions are used, retaining the ability of the ligand to bind to the target protein and internalize with it. We propose to replace EGF by a number of other ligands, such PSMA binding ligand (targeting prostate cancer) and Her-2 affibodies. Although only a fraction of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'INTEGRATED STRATEGIES FOR THE MANAGEMENT OF STEM CANKER OF OILSEED RAPE IN EUROPE', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Environment-friendly integrated control of a plant disease necessitates (i) a good knowledge of the pathogen, including its interactions with the host plant(s) and population structure; (ii) an understanding of the epidemiology and of the weather factors leading to damaging epidemics, in order to establish risk forecasting assays and Ciii) a diverse range of sources of resistance, an assessment of their efficiency under the most diverse situations allowing to predict their behaviour when submitted to different climates and populations of the pathogen.The objectives of the proposed 4-year project is to address these points to propose integrated strategies to control the most damaging disease of oilseed rape and vegetable Brassicas in Europe: the stem canker (also termed Phoma and blackleg disease of crucifers), caused by the fungal pathogen Leptosphaeria maculans (anamorph: Phoma lingam). This work will assess the efficiency of resistance currently available in oilseed rape under various situations, identify novel sources of resistance, and propose disease resistance strategies fitting each specific European situation, i.e. France, Germany, the UK, Poland and Portugal. A large number of L. maculans isolates will be collected frm diverse locations and crops in Europe. The collection will be analysed according to biological, biochemical and molecular criteria and compared to world-wide reference isolates. Simultaneously, a four-year epidemiological survey will be performed in parallel in the UK, France and Poland, both n field and controlled conditions. me main races and/or species identified in the European survey will be used for epidemiological studies and - o screen for resistance in a collection of more than 700 accessions of B. oleracea, B. rape and B. napus, includi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The effects of aging in the control of eye movements and its relation to perceptual and motor decisions' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Aging involves a series of changes affecting both our cognitive abilities and our motor performance. As any other action, the control we exert over our eye movements changes due to aging. For example, the older we are, the less accurately we pursue moving targets. Even though vision -assisted by eye movements- is the main sensory source of information we use to make most of our decisions (and especially those related to actions), the effect that changes in the oculomotor behavior have on our perceptual and motor decisions remains unknown. The aim of DECEYEDE is to define how oculomotor control evolves with age, and how these changes accompany changes in perceptual and motor decisions. To do so, we will first assess how adults of different ages look at targets in dynamic scenarios about which they have to make a decision. Several parameters such as saccade latencies, number of saccades or pursuit gain will be evaluated, and a relation between such parameters and the performance in perceptual and motor decisions tasks will be established. Second, we will apply parameter based-feedback to explore if we can train eye movements in order to improve performance. We will do so by providing feedback to participants about specific parameters of their oculomotor performance. Such feedback will try to steer eye movements towards parameters similar to those that lead to better perceptual and motor performance. DECEYEDE will advance knowledge on the effects of aging on how we sample visual information from the world around us, and will allow further understanding of the mechanisms behind the decline in perceptual and motor tasks with aging. Furthermore, a successful method to train eye movements based on parameter feedback would represent a breakthrough that would set foundational pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Iron in hemochromatosis : deleterious effects of an essential nutrient' to be submitted under Fifth Framework.

assistant: **Abstract**

Normal dietary iron causes organ damage in patients with homozygous Hereditary Hemochromatosis (HH). Heterozygotes (10% of the European population) are at risk for early cardiovascular death. HH patients absorb too much iron and have toxic non-transferring-bound iron (NTBI) in plasma. This project intends to identify the mechanism of TBI toxicity, and the damage to vascular endothelium (as target for arteriosclerosis) and to the liver. An inexpensive method for NTBI measurement will be developed. Oral iron chelator will be developed to inhibit excess absorption of iron and to scavenge NTBI. Iron absorption, as a key pathogenic mechanism, will be analysed at a molecular level. The project is expected to result in less organ damage and in prevention of early death in HH patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Simulation of co2 and water vapour fluxes in a young sitka spruce (picea sitchensis (bong.) carr.) plantation' (1994-1998).

assistant: **Innovation**

Research objectives and content Models of forest atmosphere interactions are needed both to forecast the future carbon balance of the atmosphere and forest development under a changing climate or/and forestry management. 3D models of canopy structure, radiative transfer and tree physiology are tools to describe the complex interaction between weather, tree structure and physiology. With this proposal we want to intensify the scientific l exchange between two groups working on the field of forest canopy modelling with the aim to find and validate specific strategies for plant canopy modelling In a 6 month project CO2 and water vapour fluxes in a young Sitka spruce plantation should be simulated by using two different 3D canopy models. Various field measurements were undertaken to gain parameters for the simulations. Own field measurements and results supplied by other projects of the host institution will be used for validation of the modelled output. Modelled intra canopy variability of absorbed photons, carbon assimilation and water loss will be used to quantify the impacts of aboveground competition between individual trees for light. Training content (objective, benefit and expected impact) I shall be trained in the parameterisation and the use of the 3D canopy model MAESTRA of the IERM. This includes special gas exchange measurements in the field at leaf scale, configuration of the model and the use of the model as an analysis tool. Results of the investigations in a young spruce forest will be a l necessary addition to generalise conclusions drawn from my current research in an old spruce forest in central Gerrnany. Links with industry / industrial relevance (22) At the state of the proposed investigation there are minor direct links to industry. However, the produ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Behaviour of multiphase systems under super-ambient conditions' (BEMUSAC), addressing dissemination and exploitation.

assistant: **Impact**

The project integrates physical chemistry and chemical engineering research for developing new super-ambient processes based on gas-liquid-solid contacting. It represents reorientation of R&D potential of the Centre activities towards the advanced fields of multiphase systems under extreme conditions. Such systems are important for the chemical, pharmaceutical, food and steel industry, as well as for the production of new materials of desired properties. The inovation is based on further intensification of all hitherto existing contacts and links of the Centre with academia and industry in Europe. The activity will result in the initiation of genuine networking in the field and preparation of further joint project proposals in the research of multiphase reacting systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Temporalities of Andean Heritage Landscapes'.

assistant: **Innovation**

How can project/site managers consider local categories and ideas of time when conceptualizing, managing, and protecting indigenous archaeological sites in the Andes? At a time when politicians and scholars give increasing importance to local perspectives, few models exist for addressing the conflicting temporalities of Andean indigenous heritage. My project engages this problem by undertaking an ethnographic inquiry into the Quechua category of muyuy with reference to how time is understood through the material world and use of space in the community of Chinchero, in the Cuzco region of Peru. Muyuy is an Andean long-standing, key organising and dynamic principle of socio-political and ritual life that projects social relationships onto the landscape in different forms. Semantically, it is a concept charged with the temporalities of rotation, alternation, and circulation. As customary law and action, muyuy organises communal agricultural work and production by periodically rotating the plots allocated to families for their sustenance, ensuring rights to land. While muyuy has received some previous attention in the literature, my work will examine this idea in the most depth to date. My previous doctoral research on the topic has already laid the foundations for a more thorough and productive study. An emphasis on muyuy and other temporal categories is (relatively) new. By focusing on native temporalities my project intersects current anthropological debates on indigenous landscapes, as well as current indigenous efforts worldwide to regain control over their archaeological heritage.


**Keywords:** Andes, indigenous heritage landscapes, temporalities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Use Of Metal Matrix Composite Materials Heat Pipes for the Thermal Management of High Intergrated Electronic Packages'.

assistant: **Innovation**

Electronic Integration companies are facing sharp thermal management problems in the use of existing and emerging high integrated electronic components and modules. The heat removal capabilities of existing cooling techniques are overtaken in two different directions:  increase of cards global dissipations (P > 100W)  increase of local heat densities (HD > 10W/cm2) These objectives, twice higher than the current pratices, are associated with size limitations (3 mm max thickness of the system) and high reliability requirement (thermal expansion mismatch limited to 3 PPM). The proposed multidisciplinary technological development is directed at developing an active cold plate composed of integrated micro heat pipes through the following tasks: I. Development of the phase change heat exchanger:  As regards this development, several steps will be considered:  - - Design of capillary system  - - Selection of the working fluid  - - Compatibility of the components  - - Operating limits II. Development of an advanced composite materials cooling substrate  The objective of this task is to develop an MMC based phase change system by finding solutions for:  - The functional requirements  - The electronic packaging requirements  - The possible manufacturing route (combine heatpipe systems with MMC bases or integrate heatpipes directly into MMC)  - The maunfacturing parameters  - The application specific lowable costs III. Electronic components integration and interconnection processes  - For each slected multilevel media, the analysis of the assembly process will be made and incompatibilities will be mentioned.  - The driving criterions will be coefficient of thermal expension, the ability to be brazed or glued and the resulting thermal resistance and hear removal capabilities.  - T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Logic, finite automata and numeration systems'.

assistant: **Objectives**

Research objectives and content institutions for some time. Improving the quality of care is one of he most comprehensive tasks that can be undertaken engaging both aministrative and medical staff. Implementation of this intention should be based on systematic monitoring with feedback and evaluation. The information gathered for this purpose must however be professionally meaningful, of good quality itself and not too costly to obtain. Current litterature shows that many different strategies exist for the use of prophylactic antibiotics to prevent postoperative wound infections in surgical patients and pneumonia in intensive care patients. The incidence of prophylaxis used in apparently comparable surgical interventions ranges from well above two thirds to one third, and the variety of antibiotics is also wide. In intensive care the use of SDD in Europe was recently found to vary between countries ranging from 80% of the units in some countries to 0 in others. Within the field of infection control the use of clinical monitoring systems has advanced to a point where unqualified applications should be avoided, and the time has come where the focus should be on developing relevant indicators. The project applies the essence of this experience to examine antibiotic prophylaxis in a sample of surgical and intensive care patients, and includes validation techniques to ensure comparability of data. A guideline on good antibiotic prophylaxis (GAP) as well as indicators fo verification of GAP are supposed to emerge from the study, which may act as a precursor to a forthcomin European standard in hospital infection control. The intent of the study is to uncover strategies for prophylactic antibiotic treatment in surgery and intensive care in European hospitals, to establish guide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Lidar tropospheric study at Alomar' in the context of a Sixth Framework call.

assistant: **Objectives**

ALOTROPOLID offers the applicant. Max Frioud as researcher the unique training opportunity during a stay at the ALOMAR Observatory, in Northern Norway. The applicant has experience from his recent Ph.D. work in the lidar technique and especially in the use of processing algorithms describing the vertical aerosol distribution and its effects under different weather situations in Switzertand. At ALOMAR, the Arctic Lidar Observatory for Middle Atmosphere Research, it will be possible to extend this knowledge with deeper experimental skills and a thorough extend of the used theoretical approaches describing aerosols in general and especially the climatological effect of cirrus clouds.The applicant will work with the new troposphere lidar at ALOMAR in close collaboration with the group of J.E. Kristjansson from Oslo University, who is modelling the effects of Arctic cirrus particles on earth and apos;s climate, and with a group of scientists at NILU (Norwegian Institute for Air Research), who are both experimentally and theoretically investigating different kinds of aerosols and their impact on the ecosystem. In focus for these investigations are both anthropogenic and natural aerosols, which are detected both by remote sensing (e.g. LIDAR) and chemical methods. In this context NILU stands for an interdisciplinary approach to the research field. Additionally the close contact to European and non-European groups with international reputation in aerosol research in the stratosphere and the mesosphere opens for the opportunity to combine theoretical and experimental methods, which were established in rather different height regimes in the Arctic atmosphere.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The architecture of Smc complexes and their functional roles in chromosome maintenance' to be submitted under Sixth Framework.

assistant: **Abstract**

The ubiquitous Structural Maintenance of Chromosome (Smc) proteins play essential roles in chromosome condensation, segregation, DNA recombination and repair, and gene regulation. The mechanisms by which they carry out such processes are unknown. Errors in Smc function can have catastrophic consequences, and can cause the molecular defects behind human genetic diseases such as trisomies and malignant tumour development. Segregation defects during meiosis are also the cause of approximately one third of spontaneous foetal abortions and are thus a major cause of infertility in humans.This project aims to resolve the molecular architecture of Smc complexes, and determine their mechanism of function. Using the high-resolution method of X-ray crystallography we will resolve how an essential proteins called kleisin interact with Smc proteins to produce a functional complex that associates with the DNA. Using a novel second approach, direct visualisation of the Smc/kleisin complex interacting with DNA by cryo-electron microscopy will reveal the mechanism by which the conserved family of Smc and kleisin proteins exert their topological functions on chromosomes.This research will significantly impact on the understanding of fundamental processes of chromosome maintenance and will have critical implications in the identification of factors contributing to the development of cancer and human infertility. The results from this research will eventually assist in the development of new therapies for treating major genetic defects. This research will foster scientific collaboration between the EU and Australia. In a mutually beneficial research co-operation, the Host (MRC-LMB, Cambridge, UK) is able to provide unique training opportunities (particularly in the field of structural biol