RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transcript map of the human genome by radiation hybrid mapping of expressed sequence tags (ESTs)' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Identification of genes has until recently been pursued on a case by case basis, using either biochemical and protein identification methods or positional cloning genetic techniques. The advent of large scale cDNA sequencing projects in the past few years is likely to lead to the identification of the majority of human genes in the near future. The exploitation of this huge amount of information will, however, require a means to integrate the genes into existing maps including genetic maps and physical maps. This project is part of a collaborative project whose overall objectives are to create a high resolution, fully integrated map of the human genome. In particular this project concerns a world wide effort to map the estimated 60,000 to 70,000 genes in the human genome. The method chosen by this consortium is whole-genome radiation hybrid mapping (WG-RHM) of at least 100,000 expressed sequence tags (ESTs) of which approximately 10,000 are currently in public databases and the rest are to be generated by a separately initiated public-domain cDNA sequencing project (Merck/St Louis). The consortium members have already embarked upon the project using individually initiated means of funding a significant part of the costs associated with the work, drawing upon their experience and infrastructure for performing large scale genomic projects. The present application is to request funding for three significant aspects of the project that are best done in a co-ordinated fashion, or for which economies of scale and sharing of resources can be done: (1) Maintain databases for the EST sequences and associated information; (2) Fund the synthesis of PCR primers for approximately 30 % of the ESTs: (a) automated design of PCR primer pairs for non-redundant set of ESTs, (b) commercial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European union social information research facility' in the context of a Fifth Framework call.

assistant: **Objectives**

The EUSSIRF (Florence) facility provides access to the collections, services and research instruments of the Library of the European University Institute whose academic population of PhD researchers, professors, fellows and visitors (some 600 in all), from EU member states and elsewhere, conduct research, at the highest academic level, in law, economics, history and political and social science with particular reference to Europe. The Library supports the research information needs of this multilingual user population and is very strong in its coverage of the social sciences. Collections now total over 500,000 volumes in both paper and microform, 3,500 periodical subscriptions and a large collection of working papers. Researchers have access to other information retrieval services through locally-networked CD ROMs and remote on-line databases. It has major collections in governmental and intergovernmental publications and a first-class European Documentation Centre. EUSSIRF visitors, generally staying one month, benefit from financial assistance (1,800 Euro approx.), help with accommodation, expert assistance in exploiting the facilities resources, training in new research technologies, affiliation to the Robert Schuman Centre (for access to the academic life of the EUI).Application:Main Results: EUSSIRF Florence had contracted to deliver 1,584 days of access during the period of its funding, a figure based on 72 visitors spending an average of one month (giving 22 access days per visitor).Project Manager:Peter Kennealy, Library, Via dei Roccettini 9, San Domenico di Fiesole, Firenze 50016, ItalyTel: +39-055-4685438Fax: +39-055-4685283E-Mail: eussirf@datacomm.iue.it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Water Efficient Allocation in a Central Asian Transboundary River Basin' (WE-ACT) targeting Horizon Europe.

assistant: **Abstract**

Mountainous regions in Central Asia are vulnerable to consequences of climate change. Taking appropriate decisions for allocation of water over communities, the environment and key economic sectors such as agriculture and energy, is increasingly challenging due to economic and population growth as well as climate-induced changes in hydrological regimes in Central Asia’s main transboundary river basins.WE-ACT proposes to establish a climate sensitive Decision Support System for water allocation in two sub-catchments of a transboundary river basin in Central Asia, namely the Naryn and Kara Darya catchments of the Syr Darya river basin (covering parts of Kyrgyzstan and Uzbekistan).Based on an innovative water information system that captures a thorough understanding of water availability, demand, footprint and allocation in a glacier-fed river basin, WE-ACT will enable water managers to interact with an accessible and intuitive DSS to alleviate water stress for communities, the economy and the environment on the short- and long-term. WE-ACT will enable them to adapt the allocation of water resources to the known and expected effects of climate change, while encouraging the improvement of policies to correctly set water tariffs, reduce water footprints and increase water use efficiency in agriculture and energy sectors.The backbone of the project is a reliable data supply chain based on real-time monitoring, integrated water demand-, availability- and use modelling approach, machine-learning, and data storage in a transboundary context. This will be matched with an in-depth understanding of water policies and priorities that face increasing pressures of climate change, growing demand and water dependency.End-users of the project (hydrometeorological stations, integrated mod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Towards Realistic Modelling of Nucleosome Organization Inside Functional Chromatin Domains' (InsideChromatin).

assistant: **Innovation**

Reading the genome is one thing – finding out how it functions, is something else altogether. The next big challenge to understand gene behaviour is deciphering (a) how the genome is organized in space and (b) how this organization influences its function. Inside Eukaryotic cells, genomic DNA is packed together with proteins into a remarkable structure known as chromatin. Nucleosomes, the building blocks of chromatin, interact with each other to enable high-density packaging. Our understanding of chromatin structure is limited by the lack of ‘close up views’ and molecular-level mechanistic information of how nucleosome interactions are regulated in vivo by many highly coupled factors.InsideChromatin aims to develop a groundbreaking multiscale approach that will push the current limits of realistic computational modelling of in vivo chromatin structure. The vision is to achieve the first multiscale simulation study that describes nucleosome organization inside functionally different kilobase-scale domains, while explicitly accounting for the combination of epigenetic marks, the binding of architectural proteins, and nucleosome remodelling activity that distinguishes each domain. InsideChromatin will integrate atomistic simulations with two levels of coarse-graining and experimental data for validation to understand how nucleosome organization at kilobase scales leads to physical properties at megabase scales. The output from InsideChromatin will bring us closer to the ‘holy grail’ of deciphering the connection between genome characteristics, structure, and function.


**Keywords:** multiscale modelling and simulation,  chromatin structure,  coarse-grained modelling,  genome structure,  biomolecular modelling and simulation,  molecular dynamics,  Monte Carlo simulations,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Robust Sensor Array Processing' (ROSE).

assistant: **Innovation**

Sensor array signal processing has emerged a key technology for future radar, wireless communication, sonar, and microphone array systems. Sensor array processing methods are commonly used in multi-sensor systems to estimate signal parameters (such as source directions-of-arrival and waveforms), to extract signals-of-interest received on the background of multiple interferers and sensor noise, and to transmit signals to multiple locations in a spatially selective way.  Current sensor array processing techniques are known to degrade severely if some of the exploited assumptions on the environment, sources, or antenna array become wrong or imprecise. In particular, the existing signal parameter estimation and beamforming methods are known to be very sensitive to any type of array manifold or multi-antenna channel mismodeling which may be caused by environmental non-stationarities, signal fading and scattering effects, array shape distortions, imperfect array calibration, unknown ambient colored noise, etc. As a result, advanced sensor array processing techniques can suffer a severe performance degradation in situations with even rather slight mismatches between the actual and presumed array responses. Therefore, robust sensor array processing techniques are currently of great demand. The main objective of the proposed research will be to develop new robust and computationally efficient sensor array signal processing methods for signal parameter estimation and receive and transmit adaptive beamforming in complicated environments with imperfectly known array and propagation channel parameters. The robust adaptive array processing and signal parameter estimation techniques developed during this project will be based on an explicit modeling of uncertainties in the array respo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'CEMENTS FOR DURABLE ZONAL ISOLATION OF A CASED WELLBORE' to be submitted under Fourth Framework.

assistant: **Abstract**

The aim of the project is to demonstrate to the oil and gas industry that an approach developed in R&D to maintain the mechanical integrity of the cement sheath improves significantly the durability of zonal isolation. Durable zonal isolation is necessary to prevent the migration of hydrocarbon through the annulus which can cause severe damage to the environment. This improved durability will reduce the emission of hydrocarbons in the atmosphere, will avoid any fluid cross communication between various layers, will allow a better control of the oil production and ensure a better well mechanical integrity. Zonal isolation must be maintained not only during the life of the well, but also once the well has been abandoned. The proposed approach includes a procedure to establish requirements on cement mechanical and physical properties, the use of new cements with improved mechanical properties, and recently developed measurement/interpretation techniques to fully evaluate the cement sheath integrity. This demonstration will be first carried out on a laboratory mock-up of a well then on onshore wells.The first step is the determination of the well environment. This includes a measurement of the mechanical properties of the formations and the expected loading the well will be submitted to during its entirely life. The well loading includes well pressure variation, well temperature variation, formation pressure variation and far-field stress variation. The geometry of the well has also to be taken into account such as the open hole diameter and the casing size. This step being achieved, the requirement in term of cement mechanical properties is determined using an internally developed software product, which uses as input the parameters measured above. This determines a set of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Chemistry in the Confinement of Protein Cages', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Protein cages appear to be common structures in biology, found in viruses but also in organelle-like containers discovered in bacteria. In this proposed program I aim to study chemical processes in nano-sized protein cages as mimics of bacterial organelles and to increase the general understanding of chemistry in confinement.Towards this goal we will investigate the controlled in vivo loading of bacterial protein cages, i.e. encapsulins, with proteins and enzymes. This will allow us to study in detail the chemical conversions that take place inside such capsules and it will increase understanding about the reasons why certain processes inside these simple organisms are encased in the protein organelles.Completely artificial protein organelles will be constructed by in vitro processes using the well-studied Cowpea Chlorotic Mottle virus cage. By employing DNA technology, cages will be loaded with a single enzyme, a sequence of enzymes or molecular probes. By obtaining this high level of control, we can not only study chemical conversions on the inside, but it will also allow us to monitor the physiochemical properties, such as internal pH, polarity and porosity of the protein mantle by encasing the relevant probes or host/guest systems.In the ultimate stage of the proposed project the formed artificial organelles will be brought into cells in order to interact with the cell metabolism. CCMV has to be introduced by surface modification, while encapsulins can be formed inside these cells; albeit with different cargo. Such experiments have, to my knowledge, not been carried out and introducing new reactions inside these organisms can lead to new potentially interesting products or interfere with cell vitality. The latter can be of importance for the controlled disruption of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovative SOFC Architecture based on Triode Operation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The development of Solid Oxide Fuel Cells (SOFCs) operating on hydrocarbon fuels (natural gas, biofuel,LPG) is the key to their short to medium term broad commercialization. The development of direct HC SOFCs still meets lot of challenges and problems arising from the fact that the anode materials operate under severe conditions leading to low activity towards reforming and oxidation reactions, fast deactivation due to carbon formation and instability due to the presence of sulphur compounds. Although research on these issues is intensive, no major technological breakthroughs have been so far with respect to robust operation, sufficient lifetime and competitive cost.T-CELL proposes a novel electrochemical approach aiming at tackling these problems by a comprehensive effort to define, explore, characterize, develop and realize a radically new triode approach to SOFC technology together with a novel, advanced architecture for cell and stack design. This advance will be accomplished by means of an integrated approach based both on materials development and on the deployment of an innovative cell design that permits the effective control of electrocatalytic activity under steam or dry reforming conditions. The novelty of the proposed work lies in the pioneering effort to apply Ni-modified materials electrodes of proven advanced tolerance, as anodic electrodes in SOFCs and in the exploitation of our novel triode SOFC concept which introduces a new controllable variable into fuel cell operation.In order to provide a proof of concept of the stackability of triode cells, a triode SOFC stack consisting of at least 4 repeating units will be developed and its performance will be evaluated under methane and steam co-feed, in presence of a small concentration of sulphur compound.Suc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Creative Industries Cultural Economy Production Network' to be submitted under Horizon 2020.

assistant: **Abstract**

Creative Industries Cultural Economy pROduction NEtwork (CICERONE) provides policymakers with a unique and innovative perspective from which to understand the cultural and creative industries (CCIs). Previous analyses have mapped the location and distribution of the CCIs; CICERONE innovates by exploring the flows of products and ideas that generate the economic and cultural values in and of places, and which also account for the disparities between them. Moreover, CICERONE explores the evolving relationships between cultural and the economy. Place is central to this project; place as co-produced by networks:  jobs, ideas, cultures and economies all come together in unique combinations in places, this is what makes them ‘unique’. The variations in local capacities to respond to global forces determine the past, present and future of all territories. By using the global production network (GPN) approach we develop a comprehensive understanding of CCIs (in the form of industries, clusters and networks). Furthermore, CICERONE will translate this new research into a stakeholder network, and an observatory, whose designs are reflective of the network approach. These will themselves be part of European capacity building which will serve to strengthen CCIs’ collective representation, empower sustainable co-creation, and spur local cultural resilience, jobs and economic activity. At its core, CICERONE provides an academic analysis harnessed to economic, cultural and social impacts in terms of local capacity building in, and across, places; as well as deepening our understanding of the inequalities and lack of diversity of social characteristic and economic employment opportunities that characterises the CCIs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Smart Transport Applications Designed for large events with Impacts on Urban Mobility'.

assistant: **Innovation**

STADIUM addresses the task 3.1.7 - Large event mobility management (especially in big cities) of the call FP7 – SST – 2008The ultimate goal of the project is to improve the performance of transport systems made available to a wide and differentiated range of users in the framework of large events hosted by big cities, through the development of a set of guidelines and tools to implement management support systems (mainly ICT technologies), based upon past experiences of large sport events, demonstrations in South Africa, Delhi and London and best practices of ITS applications in Europe.Main impacts: Improved performance of transport systems in host cities. Evidence of capabilities to manage high concentrated transport demand through long lasting technological solutions. Promotion of EU know how.Main outputs: (1) Design of ICT applications compliant with the EU ITS Frame Architecture procedures; (2) Demonstration of viability of European ITS technologies in emerging countries; (3) a Handbook providing guidelines and solutions for selecting, designing and implementing applications for the benefit of potential large events hosting cities.10 WPs: WP1 Management, WP2 Identification of requirements, WP 3 Handbook, WP4: Demonstrators design, WP 5a: Demonstrators implementation-South Africa; WP 5b: Demonstrators implementation-India, WP 5c: Demonstrators implementation-London, WP 6: Benchmarking and evaluation. WP 7: Dissemination and exploitation; WP 7b: Feasibility studies with Brazilian cities.Multi-disciplinary team (transport companies, ICT experts, transport policy experts), wide geographical scope (South Africa and India). Includes academic institutions, research and consultancy firms, ITS manufacturers, SMEs and Companies from South Africa and India.Proven track record