RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Homogeneous Supported Catalyst Technologies: the sustainable approach to highly-selective, fine chemicals production' (NANO-HOST), addressing dissemination and exploitation.

assistant: **Impact**

This proposal is aimed at generating new fundamental knowledge and fostering new prospects and frontiers, training and transfer of knowledge in the field of highly efficient, highly selective, supported, recyclable catalysts. Target of the research programme are strongly innovative methodologies for the preparation, recovery and reuse of single-site, multipurpose, nanostructured catalytic materials, and the engineering of reactors based on these catalysts, as this represents an essential part towards the elaboration of sustainable production processes of high-added value fine chemicals. The approach pursued will be the immobilization of homogeneous catalysts, and particularly transition metal complexes, onto preformed (in)soluble supports (heterogenised catalysts). Materials defined at the nanometric level obtained by surface organometallic chemistry will be also included. The focus will be thereupon on their applications on specific, selected reactions. In this project, we plan to use advanced catalyst design to develop catalysts in which the support allows improvements in terms of activity, selectivity, catalyst lifetime and versatility, compared to their homogeneous counterparts. This will be an interdisciplinary, jointly executed research project encompassing complementary, synthetic (inorganic supports, ligands, organometallic compounds, functionalized polymers, dendrimers, nanoparticles), reactivity (homo- and heterogeneous catalyst screening and recycle, product analysis), characterization (advanced techniques for materials and in situ investigations), engineering (continuous-flow / supercritical flow reactors) and modelling activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanistic insight into the role of glycosylation in focal cortical epilepsy through modelling in brain organoids.', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

An increasing number of neurodevelopmental pathologies are associated with disorders of glycosylation.  One such disorder is MOGHE (Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy), which is primarily caused by brain somatic mutations in the gene SLC35A2. This gene encodes the sole known ER/Golgi UDP-galactose transporter, and mutations in SLC35A2 result in loss of galactose from glycans. The only therapeutic approach to control MOGHE-related seizures is surgical resection of the affected brain region. The host lab has used this tissue to gain insight into the genomic, histological and transcriptomic characteristics of MOGHE. To better understand the pathophysiology of this condition and promote future therapeutic approaches (e.g. galactose supplementation), I will model MOGHE by generating mosaic SLC35A2 knockout myelinating organoids. Through imaging and electrophysiological approaches, I will use these organoids to understand the development of the phenotypic characteristics of MOGHE: oligodendroglial hyperplasia, hypo-myelination, defective neuronal migration, and altered neuronal electrical activity. To better understand the mechanisms underpinning these phenotypes, I will use high-throughput approaches, including single-cell RNA sequencing and glycoproteomics to identify candidate conveyors. Findings from these experiments can then be validated on patient tissues available in the host laboratory. Beyond therapeutic perspectives, the mosaic nature of this model provides an unprecedented opportunity to gain insight into the cell autonomous and non-cell autonomous roles of glycans in cortical development and function. This project incorporates the state of the art in techniques used to study brain development and glycobiology a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Seismic SAFety and Energy efficiency: Integrated technologies and multi-criteria performance-based design for building FACadEs' in the context of a Horizon 2020 call.

assistant: **Objectives**

Building facades are currently designed targeting high levels of energy efficiency, due to the urgent need for more resilient and sustainable communities, often driving the socio-political and economic priorities. However, environmentally sustainable facades are insufficient to create resilient societies. In seismic hazard zones, façade performance and serviceability can be severely impacted by earthquakes. Façade damage can occur even at low seismic intensities, leading to potential life-safety threat and substantial socio-economic losses. Safer façade systems are thus urgently needed, and SAFE-FACE addresses this need. Damage-control details and sustainable techniques are integrated to develop earthquake-proof sustainable facades for mid-rise new/built residential/office buildings. Moreover, the common façade design is advanced by integrating the seismic study. Multi-criteria performance-based tools/frameworks, including seismic safety as a decisive criterion, are developed (or enhanced) to support the design of façade systems: a novel practice-oriented tool; an advanced optimization-based tool; an innovative probabilistic-based approach. The project is built on the integration of the strength of the Participating Organizations in façade design and the Fellow’s expertise in seismic design. Involving parallel disciplines (Façade Engineering, Earthquake Engineering) and industrial/academic collaboration, the research is topical and represents both a scientific problem and a socio-political priority; it aims at the resilient and sustainable development of the European Community, and timely responds to the safety and socio-economic needs of our modern society. The action will be beneficial for the Fellow’s career, by expanding the applicant’s skills and opening up excitin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Insights into molecular recognition through analysis of x-ray crystallographic databases' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

A deeper appreciation of the nature of molecular interactions between a protein and a ligand would potentially improve the ability of chemists to design drugs. Information about molecular interactions can be obtained from X-ray structures, the number of which has increased rapidly over the past few years. It is therefore proposed to carry out a detailed analysis of the X-ray structures contained within various databases and in particular the Cambridge Structural Database. It is anticipated that this will result in the identification of a number of novel interactions as well as providing a more comprehensive description of well established interactions. Once identified, information about these interactions will be incorporated into a user friendly, relational database with the aim of facilitating the consideration of such information by medicinal chemists in designing novel ligands for proteinaceous enzymes and receptors, for potential use in therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Smart Energy Management and Strategic Decision Making Platform'.

assistant: **Innovation**

The way industries manage and consume energy is currently unsustainable. Today the industrial sector accounts for onethirdof world energy use and industrial energy consumption is set to rise by 50% in just 20 years. On average, an industryspends one-third of its operating budget on energy. This drastically increases electricity bills while reducing productivity. Upto 35% of total industrial energy, or 110€ billion could be saved every year, just through the application of energy-saving andlow carbon practices. Heating, Ventilation and Air Conditioning (HVAC) is responsible for around 40% of the energyconsumption in industrial plants. Frequently, this is the largest energy consuming type of equipment on a site and cantherefore provide significant scope for saving energy and money.W-THINK is an Industrial Energy Management System (IEMS) Software as a Service (SaaS) that optimizes and reducesenergy consumption of HVAC and superheated water using state of the art Industrial Internet of Things (IoT), Big Data andmachine learning algorithms. W-THINK collects the basic data from around the variety of sensors around the plant, analysesthis data and compares it to external data, such as future weather patterns, takes control of the plant’s systems for HVACand superheated water, and optimizes their performance to ensure optimal use of energy. This is all done automatically andin real time.Furthermore, as this software is hardware neutral and easily customisable to meet users’ needs, it is a cost effective solutionfor any scale and type of industrial plant.The aim of our project is to make W-THINK available to be used by all types of industries in Europe and worldwide. TheIEMS market is set to from 12.3€ billion in 2015 to 32€ billion in 2024, and achieving our projections will pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'FORGED MEMORIES: the Church of Late Antique Iran and the West. The Textual Construction of a Relation with the Western Church and State Through Hagiographies, Epistles, Documents (4th-5th century)', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

According to a number of sources of diverse typology and different historical reliability - hagiography, historiography, epistles, ecclesiastical documents -, the Church of the Late Antique Iran, also known as ""Church of the East"", turned to the West searching for political support and ecclesiastical legitimation. In these sources, ""West"" is to be understood as a composite reality, including both the Roman political power, often represented through symbolic, even salvific, figures (Constantine, Helena), and the entire Church located west of the Iranian state. This search for diplomatic pressure from the Roman State and hierarchical legitimization from the ""western"" Church particularly took place during the 4th-5th century, a period in which the Church of Iran bloomed as an autonomous entity, but nevertheless a religious minority, persecuted from time to time by the Sasanian authorities.  Through the edition of unpublished documents and the investigation about the reliability of known ones, the project aims at analyzing the circumstances and reasons of this longed-for intervention of the Western Church and Roman political power in both the dramatic circumstances of the persecution of Christians in the Sasanian Empire and the internal problems of the Church of East itself: to what extent and in what way does the ideological and literary re-elaboration affect the representation of this relation? What are the narrative devices adopted, and what is the role of some forged documents in that? In particular, the internal hierarchical controversies on the Patriarchal authority should receive new light through the online edition, translation, and analysis of a probably fake epistolary attributed to the 4th century Seleucian patriarch Papa Bar Aggai, that is, eight letters e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Genomics data mining for the genetic analysis of populations of the Dutch elm disease (DED) fungi (Ophiostoma ulmi and O. novo-ulmi)' under Seventh Framework.

assistant: **Concept**

RAPD analyses have shown that two inter-fertile fungal species causing the Dutch elm disease (DED) (Ophiostoma ulmi and O. novo-ulmi) coexist in elm stands in Europe, together with their interspecies hybrids. This constitutes an opportunity for a rapid emergence of new pathogenic races via interspecific gene flow. However, due to the drawbacks of the RAPD technique, new molecular markers should be designed to investigate the evolution of the pathogen populations. This project will enable the fellow to acquire the needed knowledge on the genomics of DED fungi to develop new molecular markers, in order to analyse the evolution of the populations of these pathogens in European elm stands. In the partner organization (Laval University, Canada), the fellow will develop the new markers by a mining of Ophiostoma genomics data obtained at this Canadian University. At Laval University the research program will include: (i) screening Ophiostoma ESTs libraries for microsatellites and PCR-RFLP; (ii) designing PCR-markers for several polymorphic fitness/pathogenic genes; and (iii) developing PCR-markers to detect genome changes generate by transposition of transposable elements (TEs). In the return institution (Polytechnic University of Madrid, Spain) the fellow will study the populations of the pathogens, and the evolutionary mechanisms that might lead the pathogens to overcome the elm resistance of breeding programs. The study of the populations will comprise: (iv) the levels of sexual reproduction, hybridisation and introgression; (v) the genetic structure and gene flow among populations; and (vi) the analysis of the polymorphism generated by TEs in order to investigate whether their activation increases the genetic diversity of the pathogen populations. Two potential evolutionar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Robotic, Automated and DIgital solutions for improving building renovAtion and New Construction Efficiency (RADIANCE)' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

RADIANCE is a 48-month project that aims to enhance the efficiency, safety and sustainability of the construction sector by automating the construction of new buildings and the renovation and maintenance of Europe’s buildings stock, using advanced robotics, automated and digital technologies. The main results expected in RADIANCE are (i) new robotic solutions for façade renovation, including: automation of the inspection and diagnosis workflow, including energy assessment; development of and overactuated drone platform for inspection, diagnosis and repair, capable of carrying non-destructive evaluation (NDE) probes and the pick&place of insulation panels; an NDE-multiphysics probe for evaluating concrete; a cable robot for crack repairing and anchoring to the wall of the insulation panels; and a drone for cleaning, and base coat (mortar) and finishing coat (paint) spraying; (ii) Augmented reality head-mounted display (AR HMD) for worker safety, integrating visual stimuli, pollution levels and ergonomic inputs; (iii) adapted Cooperative Intelligent Transport Systems (C-ITS) for construction (iv) improved construction site planning and their logistics, based on tactic and strategic approaches (e.g. site layout automation models, agent-based simulations); (v) an autonomous quadruped robot for monitoring, layout implementation and on-demand tool assistance; (vi) a platform for digitalizing the project and ensure data interoperability; (vi) solutions validated in 3 scenarios (renovation, human-robot interaction & safety, and construction optimization) consisting in 4 relevant environments, located in Norway, Poland and Spain, covering different EU building typologies regarding material (concrete, masonry, wood, plaster) and form & usage (e.g. residential projects, research c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'PROJECT ON A MULTI-HAZARD OPEN PLATFORM FOR SATELLITE BASED DOWNSTREAM SERVICES'.

assistant: **Innovation**

PHAROS focuses on developing a sustainable, pre-operational open service platform which integrates space-based observation, communications and navigation technologies to provide innovative services for a wide variety of users and application domains. Multi-hazard applications such as the prediction/early detection of emergencies, population alerting, environmental monitoring, crisis management and risk assessment are managed through a single, user friendly interface, targeting several users (crisis managers, operators of critical infrastructures, insurance companies, scientific/academic).Through a flexible, scalable and modular architecture, the platform will integrate the following services, which are broadly based on innovative technologies available within the consortium:- Satellite EO data access and in-situ sensors and processing;- Decision support services based on data fusion and situation assessment techniques;- A simulation platform for hazard modelling and risk assessment;- An alert message gateway to alert the population through a variety of communications means.A novel energy-efficient satellite uplink optimised for long messages will be added to in-situ sensors improving their availability and deployment flexibility. Location information from remote responders will be integrated into the common operational picture and GNSS services will be applied to disseminate alert messages to the population. A free-space optical downlink will be used to download data from a real EO satellite, achieving throughput in the order of Gbps.The project will culminate with a pre-operational demonstration in a realistic forest fire exercise, organised and controlled by fire brigades, during which the entire platform will be challenged and all services will be validated by end us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Short chain fatty acids and GPR43 in human health and disease' in the context of a Seventh Framework call.

assistant: **Objectives**

These studies will determine the physiological impact of short chain fatty acids (SCFA) which activate the G-coupled protein receptor 43 (GPR43) as dietary supplementation in treating obesity and type 2 diabetes. Non-digestible carbohydrates (NDC) are carbohydrates which are indigestible in the small intestine, but are broken down in the colon by the fermentation process of bacteria. SCFA are the major products of carbohydrate fermentation and bind to a receptor called GPR43 which is expressed on adipocytes, immune cells, pancreatic beta-cells and enteroendocrine cells that release appetite-suppressing hormones glucagon like peptide-1 (GLP-1) and peptide YY (PYY). Therefore, it is suggestive that this receptor provides a cross-talk between different organs and tissues, linking metabolism with the innate immune system. These studies aim to test the hypothesis that administration of the SCFA propionate reduces appetite by inducing anorectic gut hormone release, improves glucose stimulated insulin secretion, reduces body weight, induces adipocyte proliferation and differentiation, and regulates activation of the immune system and systemic inflammation. Should these studies prove positive then this work will propose a novel treatment option for obesity and type 2 diabetes.