RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Regulating RNAPII levels: gaining insight into the translation, assembly and transport of RNAPII subunits.' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Cellular diversity in eukaryotic organisms is obtained through differential regulation of transcription, which is therefore a heavily studied step in gene expression. Protein-coding genes are transcribed by RNA polymerase II (RNAPII), an enzyme consisting of twelve subunits. Recently, work from my host lab, the Svejstrup lab, has suggested that depleting the number of fully assembled RNAPII molecules in the cell, through degradation of its main catalytic subunit RPB1, is crucial for achieving transcription recovery after DNA damage. This finding underscores the importance of understanding how RNAPII levels are regulated. Therefore, in this proposal I aim to gain insight into the mechanisms influencing RNAPII abundance, by studying RPB1 mRNA and protein levels, RNAPII assembly, and RNAPII transport in human cells. Specifically, I will leverage my background in RNA biology and bioinformatics analysis to identify RNA-binding proteins interacting with the 3’UTR of RPB1, and study their role in regulating RPB1 mRNA turnover and translation efficiency. Moreover, using state-of-the-art selective ribosomal profiling techniques, I will determine whether RNAPII is assembled co-translationally, as was recently proposed to be the mechanism of assembly for most multi-subunit complexes in eukaryotes. Finally, I will perform a CRISPR-Cas9 screen to identify novel factors that mediate RNAPII nuclear import. Together, this proposal will elucidate the biogenesis of RNAPII, which is crucial for a better understanding of transcription regulation. The proposed experiments will enhance my postdoctoral training by broadening my conceptual and technical skills and will provide data and tools to start my own laboratory in the future. Ultimately, these findings might also have therapeutic implic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multimodal Sensory-Motorized Material Systems' to be submitted under Horizon Europe.

assistant: **Abstract**

WHAT: MULTIMODAL will develop sensory-motorized material systems that perceive several coupled environmental stimuli and respond to a combination of these via controlled motor functions, shape-change or locomotion. The sensory-motorized materials will be “trained” to strengthen upon repetitive action, they can “heal” upon injury, and mechanically adapt to different environments. They will be utilized in the design of soft robots with autonomous and interactive functions.HOW: We will utilize shape-changing liquid crystal networks (LCNs) that undergo controlled untethered motions in response to photochemical, (photo)thermal, and humidity-triggered activation. Coupling between these stimuli will allow for gated control strategies over the shape changes. I expect that the gated control strategies, in combination with stimuli-induced diffusion from surface to bulk of the LCN, will enable advanced robotic functionalities. The diffusion process will be used for supramolecular crosslinking and formation of interpenetrated dynamic polymer networks with the LCN, to allow for trainable gaiting for versatile locomotion control. We will also make mechanically adaptable amphibious grippers for autonomous object recognition.WHY: Technological disruptions are often due to new materials and fabrication technologies. Paradigm changes on how materials are perceived have profound effects on our society, well-being, and the ways we see the world. Here, we strive for a paradigm change in robotic materials. By taking inspiration from biological sensory-motor interactions, we will develop MULTIMODAL materials with autonomous and interactive features. These features go far beyond the capabilities of conventional stimuli-responsive materials, allowing us to take inanimate, shape-changing materia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The world's first universally compatible algorithm and platform for automatic interpretation of electrocardiogram analysis data'.

assistant: **Concept**

RemoteA, experienced telemedicine services developer and provider from Finland, has created a unique SmartECG tool for primary care phychians that includes a smart algorithm based electocardiogram (ECG) analysis software which enables automatic interpretation of ECG analysis data from any monitoring device and a simple international telemedicine service platform for requesting fast consulations from cardiologists.The innovation helps to address the severe cardiovasucalr diseases (CVD) challenge - the most critical and expensive healthcare problem in EU with more than 2 million casualties and €200 billion cost each year. However – since 80% of premature heart diseases are preventable, the CVD treatment field has experienced significant innovation and improvement over the last decade, especially in terms of longer analysis by remote monitoring.But the ongoing shift towards personalised healthcare, remote monitoring and telemedicine solutions are creating huge streams of analysis data that need to be interpreted by primary and secondary care professionals. This has put the whole healthcare system under heavy pressure and impeded actual implementation of medical innovations and best treatment practices.The SmartECG simple, yet very effective solution will significantly improve the CVD treatment even with current healthcare resources and equipment. The universally compatible software makes the exising ECG devices smarter and empowering the primary care physchians to perform more ECG analysis and enables wider range of people to be analysed faster, more thoroughly and more frequently than with current solutions.As a result of the SME-project, we have finalised our SmartECG solution, ensured market clearance in all targeted regions and are ready to start full scale market intr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Sustainable restoration and long-term management of contaminated rural, urban and industrial ecosystems'.

assistant: **Innovation**

Following large-scale releases of radioactivity, different urban, industrial and rural environments may be contamined for many years. Consequently, areas of industrial and agricultural production, residence and recreation may all need to be managed to mitigate the impact of contamination. Although emergency planning is conducted throughout Europe, it is focused upon short - term response with limited consideration of long-term management. To sustain acceptable living and working conditions, the ability to implement robust, effective holistic restoration strategies is paramount. This project will develop decision framework software to optimise long-term restoration strategies accounting for countermeasure practicability, cost-effectiveness and will include ethical, social and non-market economic considerations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Binding-activated fluorescent DNA/peptide chimeric probes for cancer imaging' (CHIMERA).

assistant: **Concept**

The overriding goal of this project is to mimic Nature in the design of novel nucleic acid/peptide chimera based nanodevices that can enable cancer imaging. We will design, engineer and optimize highly specific biomolecular nanodevices that undergo binding-induced conformational changes upon target binding and, in doing so, signal the presence of the cancer marker.  This scientific goal of great relevance for the clinical implications will be achieved bringing together an international and interdisciplinary group of research teams and building a collaborative environment for research, innovation and technology transfer. This program will allow the exchange of knowledge and expertise through visiting training periods for participating early-stage and experienced researchers.  The training will involve each single aspect of probe development and cancer imaging.  The research teams involved in this project encompass the requisite expertise and each of them has a particular focus on a single step of optical probe development and testing on cancer cells.  This program will help the integration and collaboration among the research teams and the establishment of a long-term collaboration between Europe and key Third Countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Advanced Driver Assistance Systems in Europe' in the context of a Fifth Framework call.

assistant: **Objectives**

Advanced Driver Assistance Systems improve road transport safety, efficiency and comfort. ADASE II provides the communication and dissemination platform between experts in the field, authorities and the public. It requires involvement of all major players. Transport authorities, road providers, E&S and automotive industry will organize expert workshop on the key areas of importance in the development of Advanced Driver Assistance systems. It relates new vehicle technology with telematic links to traffic management centres, other vehicles and service providers. Within the cluster management, information and exchange between relevant running and upcoming projects is managed and channelled. Public awareness of functions, performance and efficiency of ADASE II is of mandatory importance. All media such as web, newsletter etc. are going to be used for information and dissemination.Objectives:ADASE II is a thematic network that integrates international, national and regional activities in the field of Active Safety and Advances Driver Assistant Systems. ADASE II investigates new paths for European transport systems. Advanced Driver Assistance Systems (ADAS) are concepts to improve transport safety, efficiency and comfort without additional loads on resources (energy and land use), on environment and on quality of life. ADASE II combines new vehicle technologies (including innovative vehicle control) with telematic links to traffic management centres, other vehicles and service providers. The vehicle gains information about the (near and far) driving environment and informs the driver, warns him in hazardous situations or even reacts by releasing the driver from some driving tasks. Besides safety related aspects ADASE II will offer the basis for improved interfaces to other tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'From correct to high-quality reactive systems', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Formal verification is the study of algorithms and tools for the development of correct hardware and software designs. Two fundamental problems in formal verification are temporal logic model checking -- given a mathematical model of the system and a temporal-logic formula that specifies the desired behavior of the system, decide whether the model satisfies the formula, and synthesis -- given a temporal-logic formula that specifies the desired behavior, generate a system that satisfies the specification with respect to all environments. Formal verification improves earlier verification methods, which are based on simulation and are thus neither exhaustive nor fully automatic.Formal verification is Boolean: the system may either satisfy its specification or not satisfy it. The objective of this research is to add a quality measure to the satisfiability of specifications of reactive systems, and to use it in order to formally define and reason about quality of systems and in order to significantly improve the quality of automatically synthesized reactive systems. We plan to do so by developing a theory of multi-valued specification formalisms -- temporal logic and automata, studying the algorithmic aspects of the new formalisms, and suggesting novel applications of multi-valued automata in verification, design, and synthesis of reactive systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'COld chemistry COntrol via Field-Induced Reactivity Enhancement'.

assistant: **Objectives**

Controlling chemical reactions at the quantum level is one of the most ambitious goals in modern chemistry and physics, with transformative potential for sustainable synthesis and quantum technologies. Recent theoretical and experimental breakthroughs in the field-control of ultracold molecules have shown that microwave fields can suppress reactive loss channels in biatomic molecule scattering. These results demonstrate, for the first time, that external fields can non-invasively steer reactivity at the quantum level, opening the door to a universal strategy for reaction optimization.The CoCo FIRE (COld chemistry COntrol via Field-Induced Reactivity Enhancement) project is a theoretical effort that will build on this progress, pursuing three main objectives: (i) extending microwave control to polyatomic, chemically relevant species; (ii) investigating bi-molecular mixtures, closer to realistic chemistry; and (iii) exploring cavity-mediated reactivity control through strong coupling to vacuum photons. Central to this effort is a scattering-based framework that exploits the rotational levels of molecules to characterize and control long-range interactions. These advances will establish theoretical benchmarks for versatile quantum simulators and pave the way for cleaner, more efficient reactions.The fellowship will be hosted at the European Centre for Quantum Science (Strasbourg), under the supervision of Prof. Guido Pupillo, in a highly interdisciplinary environment at the interface of chemistry, physics, and quantum optics. Training in scattering theory, high-performance computation, and transferable skills such as project management and entrepreneurship will strengthen my career trajectory to leadership.By combining sustainable chemistry with quantum innovation, CoCo FI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Health Innovation Procurement Support Services' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Innovation procurement in health includes several complex processes including, but not limited to, needs identification and assessment, market maturity assessment, supply value chain rearrangement, digital transformation and reorganisation, demand business case definition and suppliers business models alignment, new roles for value chain actors as suppliers, users, consumers, co-creation of solutions regulated by contracts complying with the EU Treaty principles (transparency, open competition, non-discrimination and equal treatment, proportionality and mutual recognition), value generation along the innovation pathway, investors support and risks distribution between the demand and the suppliers. Such issues should be understood and addressed by all participants in the ecosystem to effectively execute innovation while also mitigating inherent risks throughout the innovation pathway.The project addresses the critical needs of public procurers (hospitals, health system and insurers) and the innovation providers (Small and Medium-sized Enterprises (SMEs) and industry) within the healthcare sector through the creation and activation of a sustainable and scalable platform of specialist advisory services on public procurement of innovation.The solution takes as a starting point the individual expertise and know how built up by each of the consortium partners in their work within the healthcare sector, dating back to 2012, which covers distinct perspectives including providing SME support, incubation and acceleration; providing consulting services on the sides of public procurers and innovation SMEs; providing legal expertise on public procurement exercises; providing access to market, access to finance, and fast tracking innovation support services. Based on the diverse set
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Strengthening cooperation in European research on sustainable exploitation of marine resources in the seafood chains- ERANET' (COFASP).

assistant: **Concept**

Research and innovation are central elements in the Europe 2020 Strategy and it is recognised that bioeconomy is an important element of the Strategy. DG RTD has issued a European Strategy “Innovating for sustainable growth: a bioeconomy for Europe” paving the way to a more innovative, resource efficient and competitive society that reconciles food security with the sustainable use of renewable resources, while ensuring environmental protection. COFASP will directly address actions envisaged within fisheries, aquaculture and seafood: 1) to enhance scientific knowledge and innovation reinforcing advice on fisheries management supporting decision making and strengthening an ecosystem-based fisheries management as central principle of the revised Common Fisheries Policy; 2) to implement the EU Strategy for the Sustainable Development of Aquaculture through development of strategic guidelines and implementation of national strategic aquaculture plans; and 3) to promote consumption of safe, nutritious and healthy European seafood and ensure traceability of seafood from net and cage to plate.Based on the earlier ERA-NET MariFish and the running ERA-NET SEAS-ERA, focusing on capture fisheries, aquaculture and seafood processing including distribution to consumers the objectives of COFASP are:1.To lay the basis for exploitation according to the precautionary principles and to enhance innovation in and competitiveness of the primary sectors fisheries and aquaculture as well as subsequent seafood processing and distribution to the consumer2.To define the science, information and data necessary to underpin the revision of the CFP and to ensure its successful implementation by designing complementary national research programmes and outlining monitoring and information/data sharing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Monitoring Genetically Modified Organisms in Food and Feed by Innovative Biosensor Approaches', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Most of transgenic plants are derived from crops of worldwide critical importance to food and feed producers: soybean, maize, rapeseed and cotton. Although the advantages presented by the genetically modified organisms (GMO), such as herbicide tolerance or resistance to insects, their cultivation has raised numerous concerns in the European Union (EU) and other parts of the world about food safety, environmental and economic impact. In spite of it, their production is steadily increasing mainly in the American countries, reaching a global area of 160 million hectares in 2011. To protect consumers, food and feed labelling legislation is in force in EU and other countries such as Brazil. The verification of its compliance demands reliable and accurate GMO detection methods, but also high throughput tools able to rapidly assess the actual prevalence of transgenic material in food and feed, which is unknown.The GMOsensor proposal intends to establish an innovative and well-organised scientific network aiming at advancing on nanobiosensor devices to assess the presence of GMO in food and feed products. The achievement of high throughput sensitive analysis requires novel approaches that combine different research areas. State-of-the-art methodologies and advanced techniques will be incorporated in this research for validation of the new tools and towards the efficient monitoring of transgenic soybean and maize derived products from diverse regions. The application of biosensors in food analysis is well suited due to their easy miniaturisation, simple instrumentation and cost-effective. The use of biosensors is promising since they answer to the demands of high sensitivity, specificity, and fast analysis. In this project, novel qualitative and quantitative bioanalytical method