RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Fetal adrenal and gonadal sex hormone synthesis in health and disease', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The differentiation of the male and female genital phenotype is established at 7-12 weeks post conception. During this period, maintaining the appropriate intrauterine hormone environment is essential. However, it is surprising how little is known about the intrauterine hormonal milieu and the consequences of hormonal alterations. During her Marie Curie Intra-European Fellowship Dr Reisch’s work provided conclusive evidence for the existence of a novel androgen pathway in the fetal adrenal and its significance for the pathophysiology of oxidoreductase deficiency (ORD), a recently described form of congenital adrenal hyperplasia (CAH). The virilisation observed in CAH due to 21-hydroxylase deficiency (21-OHD), the most common form of CAH affecting 1:10,000 newborns, intricately ties the function of the fetal adrenal cortex to sexual differentiation of the external genitalia. To date, this has been explained by excessive production of adrenal androgens via the classic pathway to androgen synthesis during fetal and postnatal life. However, during fetal life, it is highly likely that the novel alternative pathway also plays a significant role in the pathogenesis of 21-OHD. The research of this grant application will investigate the impact of the newly discovered alternative pathway to fetal androgen biosynthesis on virilisation in 21-OHD via the analysis of the steroid metabolome in urines of pregnant mothers carrying babies affected with 21-OHD and affected newborns. Secondly, the project will elucidate the impact of the fetal adrenal-gonadal hormonal cross-talk on the development of testicular and ovarian adrenal rest tumors in 21-OHD in a model of 21-OHD deficient mice. These tumors are the most common cause of infertility in 21-OHD and current data suggest that they are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The ‘right’ in human rights: Aristotelianism and Neo-Confucianism at the basis of the EU-China Dialogue', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

“The ‘right’ in human rights: Aristotelianism and Neo-Confucianism at the basis of the EU-China Dialogue” (RIGHT) is an interdisciplinary research project proposed for a Marie Curie Global Fellowship by Dr. Anna Irene Baka (PhD, The University of Hong Kong), Senior Human Rights Officer at the Greek National Commission for Human Rights and Adjunct Lecturer in Jurisprudence, EU law and Human Rights at the University of London International LL.B. Programme in Greece. This research aims to provide a ground-breaking definitional human rights framework on the basis of Aristotelianism and Neo-Confucianism, thus filling a major gap in human rights theory and practice and offering a basis for the sustainable continuation of the EU-China Human Rights Dialogue. The outgoing phase will be conducted at the East Asian Languages and Civilisations Department of Harvard under the supervision of Prof. Michael Puett. The return phase will take place at the Department of Philosophy and Cultural Heritage at Ca' Foscari under the supervision of Prof. Marco Sgarbi. The project will be assisted by an advisory board of philosophers and human rights experts, and will also involve a focus group consisting of European and Chinese academics and policymakers. Results will be presented mainly through a website, a monograph, two journal articles, a module, a policy brief and a closing conference. RIGHT becomes particularly timely due to the revival of Confucianism by the Chinese Communist Party. The project provides the opportunity to give the proponent tailored training-through-research and transferable-skills-training for the advancement of her academic career, to establish collaborations between institutions working on similar themes in the US, Europe and China, and to deploy two philosophical trad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel Composite Oxides by Combinatorial Material Synthesis for Next Generation All-Oxide-Photovoltaics' (ALLOXIDEPV) under Seventh Framework.

assistant: **Objectives**

The global market for photovoltaic (PV) cells that are converting sunlight into electricity almost doubled in 2010 to reach a massive 18.2 GW, nearly three times size of the market back in 2008. Crystalline silicon is the most common PV material today with a market share of more than 80%. New developments such as electrolyte based dye-sensitized solar cells as well as organic polymer cells have experienced remarkable progress in the laboratory but penetration into the market is still far away due to stability and sealing problems. Thus, this project will develop all-oxide photovoltaic cells based on nano-composite materials using combinatorial synthesis methods in conjunction with large throughput characterization and computational data analysis. Oxides are chemically stable, many of them are not hazardous, abundant and can furthermore be produced by low-cost methods. To challenge the inherent limitations of pure oxide semiconductors novel composite materials consisting of two or more pure metal oxides using various mixing ratios will be developed. Moreover, new fabrication techniques, powerful characterization tools and computational analysis methods will be employed that have not been available yet for material science. Combinatorial synthesis methods used in biology, chemistry and pharmaceutical research will be adopted to screen efficiently through a large amount of oxide compositions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'In-vitro self-assembly of bacterial pilus toward understanding biological long-range electron transport and the formation of conductive polymers for tissue regeneration' (CONPILUS) targeting Seventh Framework.

assistant: **Abstract**

The extraordinary electron transport (ET) via the bacterial pilus has attracted much attention in recent years as they exhibit highly efficient electrical conductivity across mm’s (or even cm’s) length scales. However, there is no consensus about the specific ET mechanism via the pilus, and it seems that both the pilus structure, which is composed of a small protein, and the cytochromes array along the pilus have a role in the efficient ET. All of the measurements up to now have been conducted by using the bacterial biofilm or by trying to ‘catch’ a single pilus. This begs for a new ‘cleaner’ type of experiment in order to systematically study the ET properties along the pilus. Thus, the first goal of this proposal is to express the genes for the pilus protein along with the gene for the bacterial cytochrome, and try to self-assemble the pilus in-vitro. The lateral and perpendicular ET of individual pilus will be measured using several techniques in order to understand the predominant ET mechanism via the bacterial pilus. The next step of the proposal will include the use of the bacterial pilus to form a polymer with superior properties, such as high conductivity, redox stability, biocompatibility, flexibility and three-dimensional geometry. These set of characteristics are ideal toward cardiac and neural cell scaffolding. Thus, the final goal of the proposal will be to use the pilus-based polymers for cell scaffolding and tissue regeneration applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Bringing the benefits of interactive digital health to the care of elderly persons with diabetes' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Diabetes is a growing problem globally, with a total number of diabetes affected people of 60 million (2015) in Europe, expected to grow up to 71 million in 2040. This problem particularly affects elderly people, as the prevalence of diabetes increases to up to 20% at age 70+. Addressing these challenges is of utmost importance considering that diabetes will be the seventh leading cause of death in 2030 and theproportion of elderly people is rising steadily. Most importantly, elderly diabetes patients have special needs, as for example diabetes-related tasks (e.g. blood glucose tests and injecting insulin) have to be handled by visiting home care nurses who also have the task of entering the results to medical records.The current smartphone solutions are not suited for elderly patients since they require fluency with smartphones and Bluetooth device connections. Glucostratus has developed a remote blood glucose monitoring system (Smart + Balance) to measure glucose levels of elderly patients, while allowing their remote follow up, guidance and better patient↔healthcare professional communication. The Smart glucometer has a built-in 3G mobile data connection which automatically sends the readings to the cloud platform (Balance) through an encrypted connection. Balance is thus a secure data storage, with embedded functionalities for data sharing (patient↔healthcare professional) and for data analysis & decision support. The concept aims to improve: i) support that diabetes patients are getting through remote monitoring and automated guidance based on their real-time blood glucose data and individual settings; ii) availability of comprehensive blood glucose history as well as analysis for decision support to healthcare professionals; iii) ability of healthcare professional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hypertension and alpha2-adrenergic receptor subtype expression' (1994-1998).

assistant: **Innovation**

ObjectivesThe overall objective of this proposal is to investigate the role of alterations in expression and function of central and renal a2-AR subtypes in the development and/or maintenance of hypertension. This objective is informed by the established hypothesis that dysfunction of central catecholaminergic pathways and changes in renal a2-AR expression are involved in the development and/or sustaining of hypertension in humans, as well as in various animal models of genetic and acquired hypertension. This aim will be accomplished by studying the expression and functionality of the three a2 -AR subtypes in brain and kidney tissues and cells from appropriate animal models with or without treatment and comparing the findings to normotensive animals and by investigating the possible existence of variant alleles of the genes encodind a2-AR subtypes in a clinically hypertensive population and their correlation with different clinical characteristics of the patientsThe overall objective of this proposal is to investigate the role of alterations in expression and function of central and renal a2-AR subtypes in the development and/or maintenance of hypertension. This objective is informed by the established hypothesis that dysfunction of central catecholaminergic pathways and changes in renal a2-AR expression are involved in the development and/or sustaining of hypertension in humans, as well as in various animal models of genetic and acquired hypertension and particularly in salt sensitive hypertension. This aim will be accomplished by studying the expression of the three a2-AR subtypes in brain and kidney tissues from appropriate animal models with or without treatment and comparing the findings to normotensive animals.Specifically we will:- Study the expression of differe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Neuroinformatics'.

assistant: **Innovation**

Neuroinformatics (NI) is a new research field devoted to the development of neuroscience data and knowledge base together with computational models and analytical tools for the sharing, integration, and analysis of experimental data and the advancements of theories of neural function. To develop this area a new 'International Neuroinformatics Coordinating Facility' (INCF) has been instigated through Global Science Forum within OECD. It was formed on Aug 1st, 2005 currently with 7 EU countries, Japan, Switzerland and the US as member states, but more countries are likely to join. INCF will have a secretariat consisting of an executive director, two associate directors and a staff of seven including programmers. The secretariat salaries and operation costs will be covered by contributions of each member state as specified in the understanding signed by each state. Within this SSA, the purpose is to grant support for an initiative to coordinate NI in a global perspective, which is the explicit goal of INCF. The objective of this proposal is to promote the INCF objectives by (1) organizing small workshops (5-15 experts) in different NI areas to be implemented. This can be databases concerned with a particular disease or neural function. The workshops will be held at the INCF secretariat. (2) Make an inventory of all NI resources available in Europe (scientific environments, training activities at PhD and postdoctoral level, different national or international funding schemes). (3) Analyse the most effective strategy to implement INCF objectives and promote an effective interaction with the national nodes. Each member state has agreed to make a national node to further the objectives of INCF. (4) Analyse the most efficient way to develop NI training programs both for student
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Copernicus Artificial Intelligence Services and data fusion with other distributed data sources and processing at the edge to support DIAS and HPC infrastructures' in the context of a Horizon 2020 call.

assistant: **Objectives**

Artificial Intelligence (AI) is already part of our lives and is extensively entering the space sector to offer value-added Earth Observation (EO) products and services. Copernicus data and other georeferenced data sources are often highly heterogeneous, distributed and semantically fragmented. Large volumes of satellite data (images and associated metadata) are frequently coming to the Earth from Sentinel constellation, offering a basis for creating value-added products that go beyond the space sector. The analysis and data fusion of all streams of data need to take advantage of the existing DIAS and HPC infrastructures, as well as the Galileo-enabled mobile devices when required by the involved end users to deliver fully automated processes in decision support systems. CALLISTO project integrates Copernicus data, already indexed in DIAS platforms such as ONDA-DIAS, utilising High Performance Computing infrastructures for enhanced scalability when needed. Complementary distributed data sources involve Galileo positioning data, visual content from UAVs, Web and social media data linking them with open geospatial data, in-situ sensor data. On top of these data sources, AI methods are applied to extract meaningful knowledge such as concepts, changes, activities, events, 3D-models, videos and animations of the user community. AI methods are also executed at the edge, offering enhanced scalability and timely services. The analysis of the extracted knowledge is performed in a semantic way and the associated analytics are delivered to the end users in non-traditional interfaces, including Augmented Reality, Virtual Reality and Mixer Reality in general. Data fusion among several types of data sources is provided on-demand, based on the end user requirements. The AI methods are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'nExt generation eMergencY commuNicatiOnS' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Current emergency systems and 112 services are based on legacy telecommunication technologies, which cannot cope with IP-based services that European citizens use every day. Some of the related limitations are the partial media support (so far, only voice calls and SMS are accepted), the lack of integration of social media, and the use of an analog modem for providing eCall services with limited data amount. As most operators have started migrating towards broadband IP-based infrastructures, current emergency systems need also to be upgraded/adapted in order to fulfill regulatory requirements in terms of Next Generation emergency services. Τhe main objective of EMYNOS project is the design and implementation of a Next Generation platform capable of accommodating rich-media emergency calls that combine voice, text, and video, thus constituting a powerful tool for coordinating communication among citizens, call centers and first responders. Additionally, issues such as call routing/redirection to the closest-available call center, retrieval of the caller location, hoax calls prevention, support for people with disabilities, and integration of social media will be addressed. EMYNOS will enable users to make emergency calls across heterogeneous devices (e.g. PCs, TV sets, mobile, AAC and haptic devices) using various mature technologies, including those making use of the Session Initiation Protocol (SIP), the IP Multimedia Subsystem (IMS), and WebRTC framework. EMYNOS will also demonstrate how the eCall concept can benefit from the IP technologies by allowing audio-video calls towards the emergency call centers and complementing location information, with photos and videos. EMYNOS involves partners with complementary expertise (telecom/satellite operator, VoIP provider, eCa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Defining the role of the tumor microenvironment in treatment resistance of OVArian cancer through patient-Derived EXplants (OVADEX)' in the context of a Horizon Europe call.

assistant: **Objectives**

Treatment resistance in ovarian cancer (OC) is common. Recent efforts have identified new treatment approaches with potential to improve its management, but their therapeutic effects are limited due to treatment resistances.Tumor microenvironment (TME) is emerging as a key contributor to treatment resistance, being the metabolic cross-talk between TME and OC one of the recently proposed mechanisms. The hosting lab has evidence that platinum-resistant OC cells have defects in serine biosynthesis which leads to an enhance uptake of serine. Importantly, exogenous serine is also required for some TME components, suggesting a possible competition for it and affecting their anti-cancer function. Thus, my working hypothesis is that metabolic cross-talk between TME and OC could involve serine metabolism, which could mediate treatment resistance.   Unfortunately, there is a lack of preclinical models of OC that recapitulate TME to study its role. In this regard, the secondment lab developed a new ex vivo platform based on patient-derived explants (PDEs) that allows the study of TME interactions with cancer cells. In OVADEX, I will use PDEs to dissect the role of TME components in treatment response in OC, and particularly, in the metabolic reprogramming of cancer cells. My objectives are to generate OC PDEs and expose them to standard and emerging therapies, to define metabolic changes in OC cells and cellular and phenotypic changes in TME before and after treatment and to associate changes in TME and OC cells to serine metabolism and treatment resistance. To this end, I will integrate innovative techniques and the access of the hosting team to a unique registry of OC patients.Through this work, I aim to broaden my scientific expertise and my international network for pursuing a