RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Reg-X310: new disruptive medicine for faster exit from aplasia afetr agressive chemotherapy of hematologic malignancies' (ExitAplasia).

assistant: **Innovation**

With more than 3.7 million new cases and 1.9 million deaths each year, cancer represents the second most important cause of death and morbidity in Europe; a significant portion is treated by chemotherapy, which triggers the destruction of red and white blood cells: aplasia. This aggressive treatment results in a severe deficient immunity and an extremely fragile health, which causes patients with leukaemia, for example, to stay 21 days at the hospital in a sterile room costing in average €25,000 per day. In this extremely difficult situation, RegStem has found the high-potential solution: the new Reg-X310 medicine which allows faster red and white blood cells regeneration, accelerating exit from aplasia and shortening hospital length of stay of at least 4 days. It is a tremendous improvement in relation to only existing medicine that speeds out aplasia for only one day. This breakthrough innovation will speed up recovery, decrease the risk of dying from a hospital-acquired infection (~7% less), and decrease healthcare cost for around €100,000/patient. Reg-X310 is a game-changing innovation which will substantially improve the treatment of aplasia and disrupt the market. Reg-X310 is being developed by RegStem, a French awarded innovative company, founded as a spin-off of the world-famous Pasteur Institute in Paris. The ExitAplasia project will allow the company to reformulate the Reg-X310 into an intravenous injection and to start the toxicological and clinical validation as well as the CE marking, necessary for the commercialisation in Europe. To accomplish this goal, RegStem will complete a feasibility study to further analyse users’ pain points and actual trends, as well as broaden European key stakeholder networks and explore new business opportunity. RegStem will le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Screening, characterisation and engineering of carbohydrate harvesting machineries of microbial ecosystems'.

assistant: **Concept**

Mammals rely entirely on their symbiotic microorganisms to digest complex glycans, issued from dietary fibers, yeasts, and the host itself. To that purpose, gut bacteria have evolved sophisticated machineries to face the structural diversity and complexity of carbohydrates, consisting of gene clusters coding for carbohydrate-hydrolysing, -binding and -transporting proteins. Since the last decade, functional metagenomics has proved to be a highly powerful technique to boost the discovery of new protein families involved in these multi-proteic systems from the vast world of uncultured bacteria, which represents the majority of gut microorganisms. By using a multidisciplinary approach, integrating genomic, metagenomic, functional and structural data, CaTSYS will decipher the structure-function relationships of novel key carbohydrate active enzymes and transporters recently discovered by functional exploration of the human and bovine gut microbiomes. Their role in carbohydrate harvesting pathways will be investigated and optimised by combinatorial engineering, thanks to the development of an original high-throughput screening approach, to render heterologous hosts capable of internalising and breaking down a large diversity of complex carbohydrates. Overall, CaTSYS will provide a promising framework to overcome future challenges in biotechnology, for the conversion of carbohydrate polymers into biosourced chemicals and/or high-added value compounds.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Investigation of noise emissions from wind parks and their impact to the design of parks' in the context of a Fourth Framework call.

assistant: **Objectives**

Objectives NOISEPARK concerns research on noise coming from wind parks. The work focuses on three major issues: 1) The prediction of noise emissions from wind parks, 2) The modelling of noise propagation including terrain effects 3) The investigation of possible design modifications for reduction of noise emissions from wind parks. The project aims at: - Improving the current state of prediction models of noise by means of new less empiric modelling approaches, - Devising a well validated prediction model for noise emission and propagation - Investigating the impact of noise radiation on the design and operation of wind parks Technical Approach The project will synthesize existing and new modular numerical tools in order to devise and evaluate a modular noise prediction tool for wind park applications. More specifically: Step 1: The wind turbines are implemented as discrete, distributed sources to be defined by the MACHINE MODEL. The intensity of the sound sources of a turbine will be based on characteristics of the inflow and of course the turbine itself. Step 2: Using a WIND PARK flow model, estimation of the inflow and its turbulence characteristics for every wind turbine can be obtained. Input to this step is the averaged velocity field that is established in the region under consideration. This is provided by the SITING MODEL. Step 3: Then the propagation model is used. The input required comprises: the estimated intensities of the sound sources as well as the characterisation of the propagation medium". For the latter the averaged wind velocity field as well as some information on the stratification will be needed. Expected Achievements and Exploitation It is expected that upon conclusion the project will have : 1) Added on the knowledge concerning the wind turbin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'PROGRAMME ON COMBUSTION TECHNOLOGIES, HUMAN RESOURCES AND LARGE SCALE FACILITIES IN EU COUNTRIES - EUROFLAM 2' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Following on from the success of the first EUROFLAM programme, ENEL-CRT will improve the access offered on its large semi-industrial and demo scale facilities, located in: * Leghorn Pilot scale plants for fundamental combustion studies are located in this area. The originality of the experiments is due to the advanced diagnostic capabilities available. * Sesta This area is devoted to research on gas turbine combustors. On the existing atmospheric rig it will be possible to carry out fundamental studies and advanced diagnostics development. The full scale test rig (up to 33 kg/sec of air at 25 bar) will be used to test new low NOx combustors and diagnostics techniques in conditions similar to those of the engine. * Santa Gilla This is an old power station equipped with two 35 MWe boilers, now completely devoted to research purposes. An existing furnace for burner testing is under modification to become a boiler simulation facility to develop new low-NOx combustion technologies. Experience will be provided in the form of a series of modules, up to 6 month duration allowing 12 investigators to be accomodated in a 12 month period. The availability and quality of access will be enhanced via the requested of funding from RTD Access Improvement Programme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of alumina forming ods ferritic superalloys as new biomaterials for surgical implant (ALUSI)' under Fifth Framework.

assistant: **Concept**

The aim of this project is to develop aluminum forming alloys (Fe-Cr-Al-Y203) with improved wear resistance as new biomaterials for surgical implants (hip/knee). The proposal is based on their unique capability to develop a fine but hard, dense, and very well adherent alpha-alumina layer by thermal oxidation. The starting material is a commercial alloy designed for high temperature applications. Thus this project gives priority to optimize its processing, in order to get the correct texture (low Young's Modulus and small grain size), the composition, and the thermal oxidation conditions. Mechanical characterization of developed alloys includes tensile, compressive, fatigue, and wear tests simulating joint wearing conditions. Bio-compatibility is assessed by corrosion experiments in simulated human fluids and cell culture on solid specimens. The influence of wear debris and ions release on the cell culture will also be investigated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Maritime Rescue. International Norm Contestation and Seaborne Migration to Italy and Australia' (MARESIA) under Horizon 2020.

assistant: **Objectives**

Between 2013 and August 2019, seaborne migration caused over 15,000 casualties in the Southern Mediterranean alone. While crucial to save lives, maritime Search and Rescue (SAR) operations have been increasingly criticized as a hindrance to effective border control. Despite being signatories to all relevant international conventions and facing mixed migratory flows comprising of both economic migrants and refugees, Australia and Italy have developed different (although eventually converging) approaches to seaborne migration. Not only governments, but also  different seafaring organizations have understood the duty to rescue in different ways. What explains variations in rescue policies across countries, over time, and between maritime actors?Drawing on constructivist international relations scholarship, this project conceptualizes maritime rescue as a contested international norm, investigating the role of norm contestation processes in informing varying interpretations of the duty to rescue. To this end, I will conduct a structured-focused comparison of maritime rescue offshore Australia and Italy between 1990 and 2020. Specifically, the project consists in two interrelated tasks. First, I will systematically compare how the Italian and Australian governments and publics have understood the moral and legal obligation to conduct SAR. Second, I will examine public and private organizations’ internalization of the rescue norm by examining the discourses and behaviour of navies, border and coast guards, shipping companies, and NGOs operating in Australia and Italy’s maritime regions. In previous years, I conducted fieldwork aboard NGO ships and published extensively on SAR in the Mediterranean. By funding the first comparative, book-lengthy study of the maritime rescue nor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'DESIGN AGAINST DISTORTION WITH LAYUP AND SHAPE OPTIMIZATION OF CARBON-EPOXY AEROSPACE COMPOSITES' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In the “DADIYSO COMP” project Swerea SICOMP covers the entire topic and will be the only partner. Swerea SICOMP will develop an FE-based simulation tool for rapid predictions of cure induced part distortions including sub models for cure kinetics, glass transition, and constitutive relations among other aspects. A balance between accuracy, complexity, and simulation time will be achieved which will enable the tool to be used for optimization purposes. Carbon-epoxy distortion calibration coupons and small demonstrator parts will be manufactured and measured to validate the simulation tool for rapid cure distortion predictions. The final simulation tool for cure distortions will be included in an optimisation framework to allow for shape and layup optimisation to account for cure induced part distortions. The optimization framework will evaluate which areas within the part have the most significant contribution to global distortion, and then adjust the tool/part shape and material layup in these areas to minimize the effects of distortion. Also an efficient part data (CAD + ply-book) to CAE interfacing method will be developed to import a part design into the optimisation environment, as well as the reverse process. Emphasis will be on creating tools that are accurate and robust, while maintaining a level of complexity that would not be overwhelming for a non-expert engineer in either cure distortion or optimization. Finally the entire package will be demonstrated on one or more use cases together with the topic manager. The final result of DADIYSO COMP will help designers to predict and prevent distortion in a reliable manner as well as give ideas on how to improve the design for manufacturing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The 4th Geneva Convention’s Drafting History as the origin of the Responsibility to Protect (R2P) and Duty to Prevent (D2P).' under Horizon 2020.

assistant: **Concept**

The objective of this project is to uncover the source materials of current humanitarian norms (Responsibility to Protect and Duty to Prevent) within the first and most important tool of International Humanitarian Law – the 4th Geneva Convention for the Protection of Civilians (1949). Specifically, this project aims to generate a comprehensive historical and legal account of the drafting process and of the 4th Geneva Convention, as to date, no such comprehensive account exists. The research agenda envisages an innovative Multi factor framework approach, examining alongside the Red Cross archives in Geneva, the important National Archives of the US, France, the UK and Switzerland (the Conventions’ Custodian), who all advocated and pushed for the Convention’s endorsement after WWII. The recent opening of national archives, following the lifting of the 50 year disclosure ban provides unprecedented access to hitherto unpublished materials, which could shed much-needed light upon our comprehension of the Convention’s terms and legal interpretation, based upon the original intentions of the drafters. With the interpretation of this convention deeply contested in both judicial and policy circles, uncovering the original drafting sources of the 4th Geneva Convention’s, could shed much needed light on questions regarding the nature of military occupation, of judicial oversight over armed conflict, and of the attitudes to be attributed to irregular fighting forces and non state actors. Recent events, most notably in the Middle East and North Africa point to an alarming tendency of the erosion of any limits to armed conduct. This process goes hand in hand with the exponential surge in civilian casualties in these armed conflicts. Uncovering the original sources which motivated dra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Function of the transcription factors Olig3 and Lbx1 in brainstem respiratory nuclei' (2007-2013).

assistant: **Concept**

Congenital Central Hypoventilation Syndrome (CCHS also known as Ondine’s curse) is a lethal condition in newborn children characterized by respiratory arrest during sleep. The understanding of breathing disorders is currently limited due to our scarce knowledge of the developmental program that controls the establishment of respiratory centers in the brainstem. The solitary tract (NTS) and retrotrapezoid (RTN) nuclei are essential for the relay and sensing of O2 and CO2 levels, respectively. NTS also participates in the initiation of inspiration, whereas RTN acts as an oscillator for the generation of respiratory rhythm activity. In the present proposal, I suggest to investigate the function of Olig3 and Lbx1 in development and physiology of the NTS and RTN, respectively.Olig3 is proposed to generate NTS neurons. My preliminary observations reveal that Olig3 (Olig3-/-) mutant mice die within few hours after birth from an apparent failure to maintain respiration. Anatomical examinations showed absence of NTS in Olig3-/- mice, suggesting that they die from a failure of the central relay neurons that transmit O2 information and control inspiration. Lbx1 is of relevance for the development of the respiratory rhythm oscillator and CO2 sensor. In a genetic screen of patients with CCHS, I identified a frameshift mutation in exon 2 of their LBX1 gene. To re-create this condition in mice and study its consequences further, I have generated a targeting vector to introduce this mutation into the mouse genome. Given the relevance of this presumptive pathological mutation for humans, it is necessary to understand its implications in development of respiratory centers such as the RTN. In envisage that the knowledge gained will contribute to defining strategies for future pharmacologi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'BEST PRACTICES AND INNOVATIONS FOR A SUSTAINABLE BEEKEEPING' in the context of a Horizon Europe call.

assistant: **Objectives**

The B-THENET Thematic Network implements a multi actor (MA) approach to modernize the EU beekeeping sector, sharing knowledge that is ready to be put into practice, while fostering innovation and digitalization. Beekeepers will be advanced toward more economically viable and sustainable beekeeping through the knowledge sharing and training of useful and applicable best practices. Our MA approach engages the entire apiculture sector (beekeepers, advisors, researchers, policymakers, industry, consumers, etc.) to collect, categorize and help select best practices and applicable research findings not sufficiently known, using a bottom-up methodology that populates two accessible platforms (“Practices” and “R&I”). Only practices that meet beekeepers’ needs, are effective and ready to use, will be selected, shared and customized in our public platform (“Exchange”) and in national sub-networks (13 National Centres), so we can take into account the differences between territories, and adapt practices to specific regions, languages, equipment, bee genetics, diseases, and the operational scale of beekeeping. This approach will support the setting-up of tailored and validated best practices.A sociological study will map out the channels most consulted by beekeepers to maximise the dissemination of practices in a specific, long-term platform (“Repository”), which is set up to share best practices in appealing, easy to understand, audio-visual materials, translated into 15 EU languages. The flow of practical information will be supported by the 13 National Centres, 3 International Centres and by the targeted events (312 national and 6 international), 1 EU manual on best practices, and 1 set of guidelines for advisors in beekeeping, thus contributing to a rapid cross-fertilization pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Decoding the Combinatorial Epigenetic Information of the Mammalian Genome with Engineered DNA Duplex Readers' (COMBICODE).

assistant: **Innovation**

In mammalian genomes, epigenetic modifications of the nucleobase cytosine occur in both strands of the DNA duplex in the sequence CpG, and they are central regulators of gene expression as well as important cancer biomarkers. However, current analytical techniques cannot reveal the combination in that these modifications occur in the two strands of a DNA duplex. The resulting inability to create genomic maps of these CpG duplex modifcations represents a major roadblock for future developments in epigenetics research and cancer diagnosis. We have engineered the first affinity enrichment probes for selectively analysing novel CpG duplex modifications, and integrated them into user-friendly and cost-effective kits for genomic mapping. In this project, we will develop and commercialize two kits for mapping of the most important novel CpG duplex modification consisting of 5-methylcytosine and 5-hydroxymethylcytosine for the epigenetics research and the liquid biopsy markets. This will provide decisive new impulses for epigenetics research as well as for cancer biomarker discovery and liquid biopsy, both large and rapidly growing markets.