RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A coordinated analysis on the development of European standards for the assessment of disablements in mental and neurogical disorders' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Objectives:- The application and testing of the concepts and criteria of mental and neurological disablement of the revised ICIDH classification in clinical populations.- The production of culturally applicable, reliable and valid assessment instruments for mental and neurological disorders in six European languages.- The promotion of this classification and instruments in Europe for use in clinical work, research, social security systems and legislation.Brief description:Diagnosis is not the sole useful indicator, both in medical research and in socio-economic research in health (burden of disease, health service utilization, evaluation of services, cost-effectiveness and cost-benefit analyses of interventions, etc). It needs to be complemented with an assessment of the consequences of mental and neurological disorders to provide a better understanding of health care needs, to estimate the costs of disease and to evaluate the effectiveness and efficiency of health care services and interventions. The lack of common definitions of the concept of disablement, makes the situation more difficult, due to the lack of comparability of research using different assessment procedures and concepts of definition. The aim of the present project is to establish a European group which is going to apply and test concepts and criteria of disablement in the area of mental and neurological disorders and test the applicability, reliability and validity of the revised ICIDH and associated instruments in clinical populations. The final aim is to produce a scheme and assessment procedures for disablements in the area of mental and neurological disorders, for use in various areas of research in Europe, policy formulation and planning in health, as well as in clinical practice, social security
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Demonstration of soil remediation technique for in situ cleaning of soils contaminated with heavy hydrocarbon mixtures' in the context of a Seventh Framework call.

assistant: **Objectives**

There is an increasing understanding that the natural resources should be kept unspoiled, which makes polluted soil and groundwater unacceptable. Therefore, soil contamination is an increasing worldwide problem, which poses severe threats to ecosystem and human health. Through the EU, thousands of sites have been contaminated by previous industrial use, former military sites and other sources of pollution. Despite of different cleaning measures applied, area of contaminated land is constantly increasing as a result of almost all sort of human activities as well as inadequate practices and accidents. The European Commission has acknowledged that soil pollution in the EU is a major issue and currently soil remediation is one of the top priorities of EU environment policy.The successfully implemented SORBENT project (Soil remediation technique for in situ cleaning of soils contaminated with heavy hydrocarbon mixtures, GA No 232533 financed from FP7-SME-2008-1 call) had led to the development of SORBENT integrated technique consisting of 3 individual components (SORBENT system, SORBENT bacterial preparation and phyto-remediation) each based on different remediation solution which has already proved it’s applicability to all types of oil in different soil profiles and convenient use. It is significantly faster, more efficient and up to 25% reduces the overall soil remediation costs.Despite the many advantages the wide market application is hampered by two main market barriers: insufficient demonstration and verification of the application of novel technique in real life projects and limitations of current polices: the demonstration is needed to ensure documentations and to gin regulatory acceptance of the novel technique. Thus the SORBENT-DEMO project is proposed with the ov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Figuring the Invisible: Conventions and Tactics in Animation for Science Outreach' to be submitted under Horizon Europe.

assistant: **Abstract**

The research will identify and raise awareness about the audiovisual conventions and communication tactics of animation in multimedia science outreach, in respect to the representation of invisible objects (too big, too small, too far away in space and time).The research is in the field of animated documentary, a major point in the Animation Studies agenda (Honess Roe, 2013). It is also based on the epistemology of scientific communication; as Daston and Galison argued (2007), «truth-to-nature» objectivity is being superseded by visuals balancing art and science. Merleau-Ponty (1964) had previously called for an equilibrium between objectivity and subjectivity in science outreach, due to the new “invisible” frontiers of knowledge. The action will start with 12 months at the Lucerne University of Applied Sciences and Arts, whose excellence in visual research and its interdisciplinary environment will support the Researcher in: 1) building a list of animations in multimedia science outreach from 1980; 2) critically engaging the conventions and tactics from the point of view of animation theory, 3) of animators and 4) of scientists (in dialogue with the resident experts on data visualization).The next 12 months will be hosted by the Department of Cultural Heritage of the University of Padova, Italy. With the collaboration of the Department of Information Engineering and the CICAP (the Italian committee for scientific skepticism), the results from the outgoing phase will be used to: a) create an open access database of multimedia science outreach about the “invisible”; b) set up educational actions; c) create a permanent committee to promote good practices in animation for science.The Researcher will take advantage of his expertise in animation history and theory, his conta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Discrete bIOimaging perCeption for Longitudinal Organ modElling and computEr-aided diagnosiS' in the context of a Seventh Framework call.

assistant: **Objectives**

Recent hardware developments from the medical device manufacturers have made possible non-invasive/in-vivo acquisition of anatomical and physiological measurements. One can cite numerous emerging modalities (e.g. PET, fMRI, DTI). The nature (3D/multi-phase/vectorial) and the volume of this data make impossible in practice their interpretation from humans. On the other hand, these modalities can be used for early screening, therapeutic strategies evaluation as well as evaluating bio-markers for drugs development. Despite enormous progress made on the field of biomedical image analysis still a huge gap exists between clinical research and clinical use.  The aim of this proposal is three-fold. First we would like to introduce a novel biomedical image perception framework for clinical use towards disease screening and drug evaluation. Such a framework is expected to be modular (can be used in various clinical settings), computationally efficient (would not require specialized hardware), and can provide a quantitative and qualitative anatomo-pathological indices.  Second, leverage progress made on the field of machine learning along with novel, efficient, compact representation of clinical bio-markers toward computer aided diagnosis. Last, using these emerging multi-dimensional signals, we would like to perform longitudinal modelling and understanding the effects of aging to a number of organs and diseases that do not present pre-disease indicators such as brain neurological diseases, muscular diseases, certain forms of cancer, etc.Such a challenging and pioneering effort lies on the interface of medicine (clinical context), biomedical imaging (choice of signals/modalities), machine learning (manifold representations of heterogeneous multivariate variables), discrete optimiz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Understanding motivations to seek and carry out female genital plastic surgeries to contribute to better informed decision-making of girls/women and to support medics in developing ethical practices' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

This project investigates why girls and women in Belgium and the Netherlands (increasingly) seek female genital plastic surgeries (FGPS) and how healthcare practitioners handle requests for these surgeries. The results will feed into the development of an informed decision-making tool for girls and women, a European standardised assessment tool to support health professionals in handling FGPS requests in a medically responsible and gender-sensitive way, and guidelines for policy-makers on how to regulate and/or reimburse FGPS. The project is important given the worldwide increase in FGPS and the current lack of insight into what drives requests for FGPS and how to handle these requests responsibly. The project creates an opportunity for Europe to establish itself as a world leader in responding to the surge in FGPS, which is happening across the (industrialised) world but which, so far, has not received an adequate response. The project is multidisciplinary and integrates theories from medical and social sciences, including medical anthropology, bioethics, and public health, transcending the disciplines’ traditional boundaries. It uses a mixed-methods approach, including semi-structured interviews, questionnaires, and desk research. The project will be hosted by Rhea, the interdisciplinary research centre on gender, intersectionality, and bioethics at Vrije Universiteit Brussels, in collaboration with the Ghent University Hospital Gender Team, an internationally renowned multidisciplinary team of plastic surgeons, sexologists, and gynaecologists who specialise in genital surgeries. With these teams’ support and my background in sociology, gender, and social anthropology and expertise in women’s health and genital surgeries, I am confident that I will successfully carry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced training courses on chemistry and biochemistry of antioxidants, their effects on health and disease, and risk evaluation of their use as functional food ingredients.', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The proposal aims at organizing two additional versions of our advanced workshops directed at the education of European junior scientists in the field of chemistry and biochemistry of antioxidants, their effects on health and disease and risk evaluation of their use as functional food ingredients. Many of the benefits of antioxidants stated in health claims on food products and food supplements still require substantial validation, as well as evaluation of the benefit-risk balance taking into account possible toxicological risks. The workshops are a combination of theoretical and practical courses and the first two editions showed that they provide an excellent way to improve the human research potential in the rapidly developing field of antioxidant functional food ingredients and supplements .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Partisan care: women’s wartime experiences in the Yugoslav Partisan Medical Corps'.

assistant: **Concept**

The onset of World War II saw an unprecedented number of Yugoslav women join the Partisan forces in the National Liberation Struggle (NOB). In order to build support amongst conservative rural populations, Partisan forces relied on the appropriation of traditional gendered structures, leading to the creation of a complex medical infrastructure heavily reliant on the participation of women. Whereas contemporary scholarship has primarily focused on the histories of women combatants or of women’s political organization, little attention has been paid to the largest demographic of Partisan women: the doctors, nurses, pharmacists and auxiliary staff tasked with caring for the sick and wounded. The MSCA project YUCARE traces the biographies of five notable women medical workers, using their wartime trajectories as a starting point for discussing the diversity of experiences encompassed within the sanitet. The project addresses two central questions: focusing on the overlooked experiences of women in the Yugoslav Partisan Medical Corps, it explores the divergences between accepted narratives and individual experiences to integrate temporal, geographic and demographic differences into a broader gendered history of World War II. Secondly, it explores how traditional gendered structures were maintained, challenged and negotiated within the Partisan army, and how these contributed to the state-building practices of the fledgling socialist state. This empirical objective is compounded by the combination of a microhistorical methodology with digital history tools, building on actor memoirs and a unique collection of archival materials to evaluate and communicate results in a web-based map format. By acquiring new skills in database management and virtual mapping, YUCARE will enable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Medical device combining viscosupplementation with pharmacological active molecule to regenerate cartilage in degenerative or traumatic osteoarthritis.' (REGHA).

assistant: **Concept**

To develop and commercialize a medical device (MD) that can effectively respond to unmet therapeutic needs in the treatment of osteoarthritis (OA), namely degeneration of cartilage. OA is a huge medical, social and economic burden worldwide. This therapeutic approach by local injection in the join will be a breakthrough innovation for OA therapy. The expected product is a combination of HA viscosupplementation with our pharmacological active patented molecule stimulating chondrocytes proliferation, the only cells producing and maintaining the cartilage matrix. Cartilage does not contain blood vessels, therefore this requires the product be administered locally. Our innovative project will provide a MD allowing an easily, affordable and cheaper solution than surgery for the therapeutic treatment of OA and should have a positive impact on the economic and social cost of OA. The commercial potential is one of the highest in the field of health because there are currently no specific therapeutic molecules on the market for this frequent degenerative disease.  Users are to be found in the aging population and people with joint injuries in need for a regenerative therapy. The feasibility assessment undertaken in Phase I will be the completion of the technical feasibility studies for combining our molecule with HA in an injectable solution, for formulation and production of the combined products including validation of its biological activities and the selection of manufacturing partners for the MD final production (processes for production of the final GLP batch and packaging will be assessed) allowing the subsequent planning & implementation of manufacturing for clinical phases. The commercialization plan will be refined using detail analysis of potential users, ROI for the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Easy way to accelerate the scale-up of innovative soft devices for Drug Discovery pipeline', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Cell&Soft is a Deeptech company based in France (AURA region) which aims to develop, produce and sale innovative solutions for in vitro cell culture, in the field of oncology and stem cell research.Pain point: Drug development process is very expensive, complex and suffers from many failures. In oncology, the average success rate is less than 4%. More than 80% of drug candidates fail in early clinical phases and this after 5 to 7 years of research. Thus, the efforts mobilized consume considerable human and financial resources, without result. Opportunities: One of the most important challenges is the lack of reliable, reproducible, and easy-to-use in vitro models, allowing better predictability and/or reliable diagnosis. Ambition: At Cell&Soft, our ambition is to re-invent in vitro cell culture, by developing innovative devices that act as steppingstones for tomorrow's drug candidates. The objective of Cell&Soft is to accelerate the discovery of new drugs with an average success rate of more than 20%, while limiting the use of animal models.Easy SOFT project: The Women TechEU program is a great opportunity to achieve our ambition by accelerating the growth of Cell&Soft. The Easy SOFT project must allow us to (1) consolidate our added value by strengthening our POCs and IP financing, (2) prepare strategic and operational commercial deployments, and (3) allow a scale up to a pre-industrial stage to meet the Pharma companies at the international level.Women empowerment: As a women scientist and CEO, I want to promote the integration of women in science and in leadership roles. I think I can challenge the status quo to create an environment where women can achieve their potential. Through the Women Leadership Program I want to deploy myself as a female mentor and gain acces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Impact of replicative stress on DNA replication timing control' (RepliStressTiming), addressing dissemination and exploitation.

assistant: **Impact**

Replication stress has emerged as a prominent driver of genomic instability. The ATR kinase is a master regulator of the cellular response to replication stress and defects in ATR activation or loss of its signaling components leads to DNA damage, genomic instability and tumorigenesis. Yet the direct mechanisms by which ATR signaling prevents these repercussions remain poorly understood. The primary aim of this study is to investigate a novel role for ATR in regulating the cellular replication timing program and corresponding gene expression. I hypothesize that replication stress caused by disruption of ATR signaling perturbs the carefully regulated timing by which genes are replicated. This directly alters gene expression patterns, potentially leading to oncogene activation and/or silencing of tumor suppressors. This idea is substantiated by my preliminary results indicating striking shifts in replication timing of select genomic loci under defective ATR signaling. Furthermore, a recent finding that ATR maintains the transcriptional status of genes in the vicinity of stalled forks alludes to a similar connection. This timely study will be the first to identify genes with altered transcriptional activity as a result of perturbations in replication timing under ATR-mediated replication stress. Functional characterization of these gene products will provide new insight into how ATR determines replication timing and direct mechanistic basis for how ATR signaling safeguards against tumorigenesis. The outcomes can better inform exploitation of replication stress in cancer therapeutics in the form of ATR inhibitors and underlying pathologies in ATR-deficient Seckel syndrome and associated hereditary diseases. By bridging the fields of replication stress and timing, I will gai