RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Resource wars in an unequal world: international law and beyond' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The growing demand for resource commodities, coupled with the climate crisis, have increased pressures on ecosystems and individuals who are already at the margins of society. Conflicts over natural resources and the environment are considered among the greatest challenges of the 21st-century. While the link between resource scarcity or wealth and armed violence is increasingly discussed by political scientists, there is still little understanding of how international law operates in this venue of global governance, where power imbalances shape relations among different actors (transnational corporations, governments, international institutions, and peoples).By conducting two case-studies, which focus on the problem of ‘conflict resources’ and the security impacts of climate change, this project will illuminate international law’s role in framing these types of conflicts and finding ways to tackle them, and the place of different actors within legal discourses. It will demonstrate how distributive concerns may be sidelined and inequalities perpetuated through legal/institutional arrangements.This project will open intellectual spaces to rethink common ‘solutions’ to the international legal order’s most pressing concerns: the ecological crisis, rising civil wars, and their interaction. It will initiate a more inclusive and much-needed debate about alternative understandings of international peace and security, which reflect the lived-experiences of peoples in the Global South. Through the integration of other disciplines into the study and critique of international law, this project presents the opportunity to open a new field of knowledge, which will spark the interest of different constituencies (e.g. legal, political, IR scholars), and aligns with the interdisciplinar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Prisons: the Rule of Law, Accountability and Rights'.

assistant: **Innovation**

PRILA will create the first account of how mechanisms for securing rights, ensuring accountability and achieving adherence to the rule of law are experienced in European prisons. Prisons are places where considerable power differentials exist, and are unique sites for the expression of the values which underpin public and prison law. Systems to ensure that prisoners are treated fairly and that rights are upheld are essential to ensure that imprisonment is conducted in ways that are just and promote good order. These are fundamental principles of the ‘European’ way in penal policy and penal law. Existing accounts of the deployment of penal power overlook key elements of how accountability, the rule of law, and rights are experienced. PRILA will document how prisoners, prison staff, staff of accountability bodies experience structures for ensuring decisions and actions taken in prison are fair, transparent, consistent, subject to appeal and review, and in compliance with principles of human rights. In doing so, PRILA will transform and extend accounts of legitimacy in prisons, judicial review of administrative action, the pains of imprisonment, and understandings of how penal power is experienced. Drawing on the disciplines of public and prison law, human rights, comparative law, and the sociology of punishment, the project will utilise legal, qualitative and quantitative research methods to create an account of how ‘accountability work’ is experienced. It will also examine how accountability structures are manifestations of penal ideologies or types of prison regimes. The project will advance current judicial and legal conceptions of accountability, the rule of law, and fairness, by reference to how these concepts are experienced in practice, and examine whether and how
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Maintenance of platelet homeostasis by tyrosine phosphatases and vascular heparan sulfates' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Platelets are highly reactive fragments of megakaryocytes (MKs) that have been implicated in all major pathophysiological processes, but the molecular mechanisms controlling the number and reactivity of platelets in the circulation remain incompletely defined. The prevailing thinking is that mechanical forces are the primary drivers of platelet production, but the logic is flawed and the evidence contradictory. What is glaringly overlooked are intrinsic inhibitory mechanisms and extrinsic cues providing a break system and directionality to MKs. Central to this model is the concept of an MK/platelet checkpoint and gatekeeper preventing platelet production in a haphazard manner, which has never been applied to this fundamental physiological process. Based on pioneering work from my laboratory, I hypothesize that protein-tyrosine phosphatase (PTP)-linked receptors and vascular heparan sulfates (HS) are critical regulators of platelet production, and that these receptors can be harnessed through the use of synthetic heterobifunctional molecules to regulate the threshold of MK/platelet activation and function in health and disease. Critical components of this mechanism, include the co-inhibitory receptor G6B that signals via the non-transmembrane PTPs Shp1 and Shp2, is regulated by vascular HSs, and is the primary gatekeeper of the MK/platelet checkpoint; and the receptor-type PTP CD148 that is regulated by vascular HS proteoglycans and extracellular matrix proteins, and is a master regulator of Src family kinases and the threshold of MK/platelet activation. Findings from this proposal will revolutionize MK/platelet biology and pioneer a novel class of tools and therapeutics for investigating and treating MK/platelet-based pathologies.


**Keywords:** platelet homeostasis, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanical integrity and architecture of bone relative to osteoporosis, ageing and drug treatment', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

With current life expectancy, osteoporosis related fractures are a considerable health care problem. The precise anatomical changes, which lead to diminish bone quality, are unknown. Bone loss occurs with ageing and estrogens deficient subjects and is generally measured by the amount of bone mass, which only partly explains the increased fracture risk. More accurate diagnoses can be made if bone quality is measured by geometry, architecture and matrix tissue properties also. However, these cannot be measured in vivo, yet. The proposed project will use a newly developed micro-CT scanner to follow the architectural changes in the bones of animals as a function of ageing, estrogens deficiency and drug treatment. The mechanical consequences of architectural changes or matrix tissue changes will precisely be determined using computer models and micro mechanical testing, witch will provide new information with respect to aetiology and osteoporosis treatment.Achievements from objective:The innovative in-vivo micro-CT scanner designed by Skyscan is marketed now and a number of them has been already sold. Our initiative has received considerable attention by other players in the field. Two other manufacturers have now in-vivo micro-CT scans on the market as well. Recently a discussion list on internet was started by the Erasmus group www.lsoft.com/scripts/wl.exe?SL1=3DMORPH-L&H=NIC.SURFNET.NL In the third year (2002) most of the animal experiments (plus in-vivo scans) that where pivotal in the project were made. Academic partners have received bones from this experiment I the course of 2002 and 2003 and have performed various experiments with these bones according to the protocols they have set up in the first and second year (2000 & 2001).Hence, the most important result in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The role vision plays in shaping the representation of numbers.' in the context of a Horizon 2020 call.

assistant: **Objectives**

In the literature on numerical cognition, vision was for a long time assumed to play an important role in the development of number representations. In line with this idea, I recently demonstrated that congenitally blind (CB) present a qualitatively different representation of numbers by comparison to their sighted peers. In this project, I propose to further explore with fMRI techniques whether the CB qualitative different numerical representation is supported by specific cerebral reorganisation of the brain. I also propose to examine whether the qualitative different numerical representations of CB could delay the acquisition of numerical concepts in childhood. I finally propose to explore the extent to which this knowledge of the blind’s numerical representation could be extended to the elaboration of a multisensory mathematics teaching program. I advocate the idea that this research program is crucial because poor mathematical competencies are common among adults and result in employment and day-to-day activities difficulties. Further research into multisensory access to numerical information could therefore lead to education benefits in teaching mathematics to young children but could also promote interventions that target specific mathematical deficits. I am uniquely suited for working on this project due to a number of parallels between the skills the proposed project requires, and the skills I possess. This includes: 1) my successful collaborations with Dr Collignon in the past; 2) good inter-personal skills; 3) my strong background in the research topic; 4) working with a variety of participant populations, and combining different methodologies. If funded, the present project will allow me to continue to explore a large overarching question by applying my pre-e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Supporting Active Ageing through Multimodal coaching' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

As in the rest of the world, Europe faces an on-going crisis in caring for its aging population. Citizens are living much longer than ever before, with increasingly complex medical, social, and infrastructural needs, but most EU social support services and structures are lagging very much behind the growing need.  While many efforts have focused on better access to healthcare and the expansion of assisted and social care housing, one of the main intervention points, enabling the aging population to remain in their homes longer, is just now becoming a primary developmental priority.  Caring for the aging population as they transition from active and independent lifestyles to those requiring significant external support is a large and complex field, with many approaches to the great diversity of citizen need profiles. Within the SAAM project (Supporting Active Aging through Multimodal coaching) we focus upon innovative, technology-enabled approaches to support the aging population living at home, with a novel and practical emphasis on ambient sensing and learning of user needs and preferences, and effective coaching by leveraging the user’s social support networks.  Over three years, the project’s partners will develop and test new methods allowing Europe’s aging population to remain active, independent and longer in their homes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Beyond the breadline: Charitable food provision and survival strategies of the urban poor in a comparative perspective' in the context of a Horizon Europe call.

assistant: **Objectives**

Food charities have become essential pillars in assisting the urban poor, offering a crucial buffer between food insecurity and hunger. Their significance, particularly after the Great Recession, is underscored by two pivotal shifts: one towards the sustainable utilisation of food surplus and waste reduction, and the other reflecting societal changes with diminishing welfare benefit provision. While considerable research addresses food insecurity and support, the literature lacks a robust framework to understand and compare Charitable Food Provision (CFP) across countries and cities. Despite the almost universal occurrence of such transitions, existing studies have not yet contextualised this phenomenon within the diverse arrangements of welfare and civil society regimes, and the influence of transitions in agri-food sustainability on CFP. Accordingly, this proposal aims to:1. Use event sequence analysis to chart the historical trajectory of CFP in Italy, Japan, and the Netherlands, examining the emergence and consolidation of professionalised CFP sectors in diverse institutional settings.2. Adopt mixed-methods social network analysis to examine current CFP dynamics in Palermo, Kyoto, and Rotterdam, focusing on providers interrelationships, operational modes, and their ties with both state and non-state authorities.3. Harness urban ethnography to investigate the interdependence between food insecurity and support to understand how CFP becomes part of poor people’s survival strategies.Additionally, it introduces an innovative tool, tailored for city workshops, to facilitate real-time data collection on (CFP) urban dynamics. Hence, it combines the findings obtained by crafting an overarching framework to extend CFP comparison to other countries and cities. The research wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Hybrid drug-loaded plasmonic photothermal microneedle patch against skin infections' in the context of a Horizon 2020 call.

assistant: **Objectives**

In this proof of concept project, we will assess the technical and commercial feasibility of a hybrid microneedle patch for the treatment of nosocomial skin infections caused by drug resistant bacteria. Not only does this device permeate difficult-to-penetrate skin layers to deliver antibiotics locally, it also weakens bacterial defences by raising local temperature to enhance drug effectiveness. In this manner, the need for high dosage systemic drug administration is avoided – reducing occurrence of associated side-effects and perpetuation of antimicrobial resistance. It holds the potential not only to revitalise antibacterials for topical, local treatment of skin infections, but to improve dermatological drug delivery as a platform device. In this project, we will validate the device’s fabrication process for additional commercial scalability and functionality with nanocarrier-drug complexes (for enhanced effectiveness of drug delivery to target site), develop a robust IP strategy and secure initial patents, and conduct extensive market analyses and competitor landscaping. Finally, we will formulate a strong business case, and depending on the results of these activities, establish a company.


**Keywords:** Nanoparticles, process engineering, photothermal, skin treatment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Investigation of Disruptive 2D/Silicon Technology for Hybrid Multispectral Photodetection' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

My research ultimate goal is to develop novel approaches for multispectral detection in emerging 2D hybridsilicon technology and unify in one single technological platform high-performance photodetectors in allspectral bands from visible to mid-infrared. Theoretical and experimental methods will be applied to study new concepts and physical phenomena for broadband photodetection in integrated 2D/Silicon hybrids, aiming for innovative solutions, novel device architectures and disruptive technological development of multispectral photodetection systems-on-chip. A diversity of modern applications ranging from remote healthcare and environmental monitoring, gas sensing and hazard detection, food and water inspection to biosensing and automotive vision share similar urgent needs for high-performance, miniaturized and lightweight multispectral optical sensors monolithically integrated with low-cost and high-functionality silicon electronics. However, current semiconductor photodetectors technologies are mainly tailored and optimized to specific spectral bands. Their roadmaps have so far prevented the development of universal detectors that could simultaneously address multiple spectral domains. Thus, there is a pressing need for a radically new approach that could combine high-performance broadband photodetectors in all spectral bands in one single silicon-compatible technological platform. Graphene and 2D materials integration with silicon technology open an unprecedented opportunity to reach this goal, leveraging unique ultra-broadband absorption properties of graphene and diversity of 2D-family with mature silicon fabrication facilities for monolithically integrated, scalable and cost-effective multispectral imaging systems.The fundamental study, exploration, and technolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Design for environmental concerns and materials recovery' in the context of a Fourth Framework call.

assistant: **Objectives**

Manufacturers are requested to reduce hazard emissions not only during the production phase but also during the utilisation phase of the products by their customers. Further more they are facing the obligation of taking care of these products at the end of their life. Product design has been based on functional analysis and value engineering. Functions and costs related to the all life and to the impact on environment of the product has not yet been included in these methodologies of product design. After the time of design for manufacturing, design for maintainibility, the time of design for environmental concerns and material recovery is coming. New design tools are needed. They can be developed within the frame of value engineering. For that the designers must be able to enter a collective learning process with all the downstream actors. These downstream actors are not only manufacturing engineers or parts suppliers as in concurrent engineering, but also distributors, consumers, collectors, recyclers. The participants of this exploratory phase network have decided to join their efforts for an inventory of the research and experiences already developed on this topic.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Effects of Nutrition and Lifestyle on Impulsive, Compulsive, and Externalizing behaviours' (Eat2beNICE).

assistant: **Concept**

Maladaptive impulsivity and compulsivity predispose to antisocial and addictive behaviours. Factors influencing those traits are not well understood, but diet, lifestyle, socio-economic status (SES), sex, and heritability play pivotal roles. Here, we aim (1) to identify nutrition and lifestyle drivers that can be employed to prevent detrimental impulsivity/compulsivity in males and females across the lifespan, (2) to characterize the etiologic paths leading to extreme behaviour, and (3) to promote policy changes to counteract maladaptive impulsivity/compulsivity by disseminating evidence-based information about health-related behaviours to families, clinicians, policy makers, and general public. We use epidemiologic approaches in the world-wide largest existing samples to investigate association of nutrition components & lifestyle with impulsivity/ compulsivity, and how such associations are moderated by age, culture, sex, SES, and genetics. We assess beneficial effects of key nutritional interventions through RCTs in highly impulsive males/females, going beyond state-of-the-art by directly comparing personalized, high-intensity approaches with one-size-fits-all and microbiome-dependent supplementations. We study the protective potential of acute exercise and habitual physical activity. We monitor intervention-induced changes in real time through objective mHealth-based experience sampling. Uniquely, we study effects of the gut-microbiome and its metabolites, as well as brain connectivity and epigenetic patterns as mediators and predictors of behavioural change. We initiate and support societal change by media-based information and education. We innovate the field by measuring behavioural change using social media downstream of educational campaigns and by translation o