RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Dynamic mechanical properties of cartilage: influence of loading conditions on properties and structure'.

assistant: **Objectives**

The key goals of this study are to better understand the properties that prevent articular cartilage from sustaining mechanical damage, and to determine which mechanical factors encourage cultured chondrocytes to produce structural macromolecules that enable cartilage to withstand mechanical loading.These key goals will be achieved by:(i) determining the storage and loss moduli for cartilage from lower limb joints, using cyclic loading test conditions;(ii) determining their relationship to structure (i.e. collagen orientation), using microscopy (light and electron) and x-ray diffraction techniques;(iii) culturing chondrocyte cells on modified alginate gel scaffolds, under intermittent loading. The boundary conditions applied to these cultures will be varied (i.e. loading rate, peak load) in order to determine how variations in loading alter the production of structural macromolecules that enable cartilage to withstand mechanical loading.Results from (i) and (ii) above enable predictions of trends as to how alterations in loading alter properties, and the relationship of these properties to the tissue structure. These loading conditions can then be isolated using cell cultures (iii) enabling predicted trends to be confirmed/refuted.Essentially, this study aims to determine which physical loading parameters aid the maintenance healthy cartilage. This is important because alterations to loading are thought to be involved in cartilage degeneration as occurs during osteoarthritis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cognitive mechanisms that lead to age related memory deficits' (ChArM).

assistant: **Concept**

It is well established that aging results in deficits in memory functioning in a variety of memory tasks. However, there is a debate over the specificity of the mechanisms that lead to the pattern of age-related deficits.  The aim of the proposed project is to contrast two major classes of theories in an important but somewhat understudied empirical domain: retrieval dynamics, which can allow a direct test for the distinct predictions of the theories. Proposed studies use the speed-accuracy tradeoff (SAT) procedure to evaluate differences between young and old adult groups in terms of asymptotic accuracy and speed of retrieval. This procedure allows the separate assessment of the contributions of automatic and controlled processes to memory performance discrepancy between the two groups. In doing so, this project have promise to better inform computational models of the effects of aging on memory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Optimality and Resetting: Investigation On Nonequilibrium' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

ORION project (Optimality & Resetting: Investigation On Nonequilibrium) poses three different problems, relevant at both the fundamental and applied level. Apart from their independent relevance, the solution of all three problems will serve to a greater purpose: providing a solid basis for the innovative use of optimal control theory to push the boundaries of knowledge within the general field of Nonequilibrium Statistical Mechanics. This action will involve the integration of the researcher in the very active group of Interdisciplinary and Nonequilibrium Physics (FINE) at University of Seville, with a strong background on the theory of mesoscopic systems—e.g. colloidal particles, for which fluctuations are important and the dynamics is thus stochastic. More specifically, the research objectives of ORION splits into: (i) the generalization of optimal control theory to connecting nonequilibrium steady states; (ii) the optimization of stochastic heat engines; and (iii) the minimization of first passage time in resetting systems with stochastic return. The achievement of these objectives will provide not only specific answers to pertinent questions for the above hot topics in the field, but also shed light on the future of investigation on nonequilibrium systems. Remarkably, the impact of our research transcends the purely theoretical interest, focusing on problems with future technological potential like the optimization of nanodevices—maximizing their power and/or efficiency.


**Keywords:** nonequilibrium statististical mechanics,  stochastic processes,  optimal control,  shortcuts to adiabaticity,  stochastic thermodynamics,  Fokker-Planck eq.,  stochastic heat engines,  stochastic resetting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Applying novel single-cell multiomics to elucidate leukaemia cell plasticity in resistance to targeted therapy'.

assistant: **Innovation**

Novel targeted therapies are increasingly applied against a wide range of cancers. Although such agents can induce cures, most patients suffer from relapsed disease. Acute myeloid leukaemia (AML) is a prime example of a deadly disease, but we have a chance to dramatically improve outcomes if we can better understand resistance mechanisms against targeted agents that are transforming AML treatment, such as the BCL2 inhibitor venetoclax. AML is characterised by profound alterations in the epigenome that are correlated with poor survival. I therefore hypothesise that targeted drug pressure induces epigenetic plasticity that allows cancer cells to sample alternate chromatin or transcriptional states, a subset of which confer drug resistance. A major challenge is to define how mutations of epigenetic regulators in AML affect therapy responses due to clonal heterogeneity. To address this challenge, I will use and further develop my recently published single-cell Rapid Capture Hybridization sequencing (scRaCH-seq) method to link the genotype of expressed genes to transcription and methylation profiles of thousands of single cells. In this research proposal, I aim to (1) develop a new method linking epigenetic landscape, genotype and transcriptome at a single-cell level and define the impact of treatment on these interactions. (2) Analyse the genome-wide impact of epigenetic therapies. (3) Define the association between drug sensitivity and epigenetic modifications regulating pro-survival genes. To achieve my goals, I will apply my novel single-cell multiomics to samples from AML patients treated with venetoclax alone or in combination with epigenetic therapies and apply state-of-the-art technologies to established laboratory models. Our new approaches to fully understand the r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A prosthetic heart valve for adults and children, made from the patient’s own tissue, a replacement heart valve that lasts a lifetime' under Horizon Europe.

assistant: **Concept**

Each year 400,000 people are born with heart valve defects worldwide. Moreover, in the western world, 1 in 8 healthy adults will develop a heart valve problem during their lifetime. Current artificial heart valves made from animal or human donor tissue carry a high risk of tissue rejection, degradation and calcification that limit their lifespan to about 10 years, forcing patients to undergo risky cardiac re-surgery. For children, no dedicated valve product exists, thus, paediatric patients can endure 4-5 surgeries between 0-18 years of age as their bodies outgrow each replacement heart valve. At GrOwnValve we have developed a paradigm shift in heart valve technology: the first autologous valve, grown from the patient’s own tissue, crafted using medical imaging and a 3D printing technique. Our valve lasts a lifetime, eliminating tissue rejection and surgical risks associated with repeated surgery (bleeding, infection and death).


**Keywords:** heart valve,autologous valve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sustainable Transitions through Democratic Design' (CoDesign4Transitions).

assistant: **Concept**

CoDesign4Transitions will develop 10 transdisciplinary Early-Stage Researchers (ESRs) at the intersection of co-design, design for sustainability, service and systems design, democratic innovation and climate transitions equipped to develop new approaches and validated prototypes for action. This is urgent to enable governments, businesses and civil society to deliver multi-level solutions required to achieve net zero targets committed to in the Paris Agreement. Design is central to achieving this because of its capacities for enabling experimentation through prototyping to reduce the risk of failure; synthesising ideas and evidence into material and visual forms for engaging stakeholders in co-creation; and facilitating innovative change. In contested sustainability transitions, design provides a connective tissue essential to engaging publics in democratic innovation towards net zero. CoDesign4Transition offers ESRs the possibility to develop crucial new approaches to democratic design for climate transitions in a cross-disciplinary, intersectoral environment. This will provide a unique training experience for each ESR, who will benefit from access to expert supervisors and mentors from academic and non-academic sectors. The network comprises 6 leading higher education beneficiaries and 13 Associate Partners from 9 countries, who will provide advanced training including transferable skills. 10 non-academic organisations will host secondments where ESRs will develop and test design approaches to transitions and critically assess how to build design capabilities. The 4-year research and training programme comprises research work-packages investigating prototyping, materialisation and visualisation, and facilitating practice-systems change in democratic climate transitio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Develop of a new and highly effective modeling and monitoring Energy Management System technique in order to improve Energy Efficiency and move to a low CO2 emission in the energy intensive non-metal' (EE-QUARRY) under Seventh Framework.

assistant: **Objectives**

The EE-QUARRY project emerges from the necessity to control a very demanding energy-intensive industry, which characterizes from its high energy demands and enormous CO2 emissions. The goal is to improve energy efficiency and to reduce CO2 on quarries, through the develop of a new and highly effective modeling and monitoring Energy Management System technique. The use of crushed stone could increase at a quicker rate than any other major material use. Given the market size, ample resources and stable growth potential of this industry, the understanding and dissemination of energy efficiency opportunities is paramount for European energy efficiency goals. Further, since there are literally several thousands facilities throughout Europe, there is a huge opportunity for replicability of identified energy efficiency measures. This project will first review the stone mining and crushing production processes. It is also important to show that energy use is focused in rock blasting, shot-rock transportation, rock crushing, conveying and screening. As such, standard building energy efficiency measures such as lighting retrofits and support system optimization have small impacts on overall plant energy use. The identification of energy opportunities thus relies heavily on systems optimization. System optimization not only encourages energy efficiency, but typically benefits production as well. Coupled with productivity improvements, the economic incentives for energy efficiency measures in this industry have the magnitude and quick payback that could facilitate industry-wide replication. Once the whole extracting industry process is over, and the quarry plant arrives to the end of its life cycle, many CO2 neutralizing activities will take place. The goal is to generate EE opport
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European Research Infrastructure for Heritage Science Implementation Phase' (2021-2027) under Horizon Europe.

assistant: **Objectives**

The European Research Infrastructure for Heritage Science (E-RIHS) was designed as a pan-European distributed infrastructure with the vision of replacing the traditional science-for-art approach to conservation through the new widely interdisciplinary sector of Heritage Science (HS) to improve the understanding and sustainable preservation of cultural heritage. E-RIHS was admitted in the 2016 ESFRI Roadmap and is now preparing its step 2 application to take the legal form of an ERIC. The E-RIHS Implementation Phase (E-RIHS IP) consortium brings together representatives of the national nodes of the countries that expressed their willingness to support the establishment of the ERIC and one permanent observer. It aims at enabling the E-RIHS implementation phase and preparing the operation of E-RIHS ERIC, also in support of its positioning as the reference RI for the HS domain at the EU and global level. The objectives and methodology underpinning the E-RIHS IP work plan target and intend to overcome the bottlenecks highlighted in the recommendations of the 2020 ESFRI monitoring report, the EC High Level Expert Group report (2020) and the ERIC step 1 assessment (2021). Coordinated actions are dedicated to: (i) implement the E-RIHS governance structure and finalise its distributed architecture; (ii) support the E-RIHS management with strategies and related implementation plans regarding HR, procurement, risk management and quality system; (iii) maintain and build upon the established E-RIHS excellence in user access and foster FAIR open access with the design of the DIGILAB platform; (iv) strengthen international cooperation, cultivate synergies and consolidate the HS community around E-RIHS, while establishing E-RIHS in the landscape of EU RIs and global initiatives; (v) se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Rational Design of Ceria-Supported Non-Noble Metal Nanoalloys as Catalysts for the Selective Direct Conversion of Methane to Methanol' (4lessCH4), addressing dissemination and exploitation.

assistant: **Impact**

Methane (CH4) is a potent greenhouse gas that can come from many sources, both natural and manmade. The low temperature direct route to converting methane to methanol (CH3OH) a key feedstock for the production of chemicals that can also fuel vehicles or be reformed to produce hydrogen has long been a holy grail. The efficient use of  CH4 emissions require catalysts that can activate the first C-H bond while suppressing complete dehydrogenation and avoiding CO/CO2 formation. The potential benefit of finding non-expensive and efficient catalysts for directly converting methane to methanol (DMTM), using only molecular oxygen, and perhaps water, is significant and new catalysts are being sought. This project aims to the rational design of such catalysts based on non-noble metal nanoalloys/reducible oxide systems. There are key challenges to be addressed, namely, to improve reactants activation, to obtain an understanding of the reaction mechanism and to improve selectivity. Real powder catalysts are too complex to enable us to disentagle the effect of the nature of the metallic phase (composition, structure, nanoparticle size), the  role of the oxidic support and of metal-support interactions, and the role of alloying and water in controlling selectivity. The strategy here consists of creating and investigating model systems, which include essential parts of the real ones, but can still be studied at the atomic level using state-of-the-art computational methodology in chemistry. Calculations will be performed in close collaboration with experimental work employing well-defined model systems as well as powders. The synergistic power of theory and experiment is crucial to design new or improved catalysts. Theory will not only be used to explain experimental data, but also for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Energy Social sciences & Humanities Innovation Forum Targeting the SET-Plan' (Energy-SHIFTS) targeting Horizon 2020.

assistant: **Abstract**

Energy-SHIFTS “Energy Social sciences & Humanities Innovation Forum Targeting the SET-Plan” will contribute to a European Energy Union that places societal needs centrally, by further developing Europe’s leadership in using and applying energy-related Social Sciences and Humanities (energy-SSH). Our consortium brings together 4 leading interdisciplinary research institutes with 3 highly respected policy, industry and communications organisations from across the energy-SSH field, to create an innovative and inclusive Forum. Our partners have significant energy-SSH H2020 project experience, direct working links with the EU’s Strategic Energy Technology Plan (SET-Plan) communities, extensive networks in the energy domain, and represent excellent coverage across SSH disciplines and across Europe. These will enable us to maximise the impact of our Forum delivery within an intensive 2-year project. Energy-SHIFTS activities will target over 10,000 stakeholders and begin with scoping activities including: accessible guides to SSH in EU policy; workshops on SSH priority themes; online policyworker and researcher databases. We will build on this scoping work to implement: 4 Working Groups across SET-Plan themes; a Policy Fellowship scheme; an Early-Stage Researcher programme; masterclasses for policy, NGO, STEM, and media audiences; 4 online citizen debates; and a pan-European conference.  Our consortium will bring their considerable expertise in research-policy dialogue to these activities. Our core activities will both provide immediate insights for the short-term directions of EU energy policy as well as foundations for longer-term mechanisms that will enable evidence-based energy-SSH insights to reach the ‘policy front line’.  As a central body bringing SSH communities togeth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Hormone-Induced Resistance to GLP-1 Receptor Agonists in Diabetes: Unraveling the Molecular Complexities' (GLP1RES) under Horizon Europe.

assistant: **Objectives**

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have revolutionized the treatment of type 2 diabetes mellitus (T2DM). However, a subset of patients does not respond to these agents or develop treatment resistance, which poses a significant clinical challenge. Emerging evidence from our work in humans and mice shows that endogenous amidated hormones synergize with GLP-1RAs to reduce glycated hemoglobin, and their absence promotes GLP-1RA resistance. This proposal explores the intricate mechanisms by which endogenous amidated hormones affect endogenous GLP-1 secretion, modulate its function, and influence the effectiveness of GLP-1RAs. Furthermore, it will investigate which characteristics predict the GLP-1RA effectiveness in patients, and test potential therapeutic approaches to prevent detrimental GLP-1 resistance mechanisms with the goal of ameliorating T2DM treatment and outcomes.A plethora of approaches will be used to elucidate amidated hormone-induced GLP-1 resistance. We will study L-cell functions and GLP-1 endogenous secretion in vitro and in vivo in the absence of amidated hormones. With tissue-specific genetically engineered mice, we will selectively deplete key amidated hormones that counteract the effects of GLP-1RAs and dissect their contribution in physiological readouts of GLP-1RA resistance. Lastly, we will leverage machine learning approaches to clinical data analysis on large deeply phenotyped biomedical cohorts to select for patient characteristics that determine the likelihood of developing GLP-1RA resistance, and to assess the combinatorial contribution of amidated hormones on T2DM susceptibility.By combining experimental and computational approaches, this project aims to gain a deeper understanding of the complex interplay between endogenous h