RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Quantum electronics using scanning tunnelling microscopy based lithography' (QUEST).

assistant: **Innovation**

The objective of the QUEST project is to push the fabrication of silicon based devices below the 20 nm limit using SPM-based (scanning probe microscopy) lithography in order to:- take advantage of the Coulomb blockade effect in an innovative architecture of single electron memory operating at room temperature- to study transport in low dimensionality structures that exhibit physical effects such as ballistic transport, quantum interference and single electron phenomena,- demonstrate the efficiency of a fabrication process that uses local probes (e.g. STM-Scanning Tunnelling Microscopy, AFM-Atomic Force Microscopy) for fine and reproducible patterning.Nanometer scale structures in which dimensional confinement (e.g. resonant tunnelling, Coulombic effects...) become first order effects will result in new opportunities and concepts to take full advantage of low power quantum electronics. However, the path to the optimal use of these effects in solving problems of mainstream technology is still not clear. On the other hand, scanning probe microscopy (SPM) techniques that have demonstrated potential for atomic-level manipulation of matter have not yet been fully developed to solve fine patterning constraints at the nanometer scale.The QUEST project has the objective to develop device concepts and fabrication techniques relevant for future industrial applications:- the integration of memory circuits using the Coulomb blockade is probably the most obvious application that meets the scaling and low-power requirements necessary for the giga to tera bit capacity.- processing (deposition, etching, oxidation), experimental, and theoretical developments necessary to this project will contribute to further developments of microelectronics. In particular, the fabrication sequence prop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'microRNAs and Neurogenesis Control' (NEUROMIR).

assistant: **Concept**

Vertebrate brain development and function require the life-long regulation of neural stem cell maintenance and neuronal production. Recent evidence, in part obtained in the host laboratory, suggest that the microRNA miR-9 might be an important regulator of neurogenesis, by driving neural progenitors towards differentiation. Notably, injection of a miR-9 morpholino antisense oligonucleotide into zebrafish embryos decreases neuronal differentiation in the embryonic hindbrain. The spatio-temporal expression pattern of miR-9 is suggestive of a neuronal subtype-specific action. The researcher will thus characterize more precisely the neuronal deficit of miR-9 morphant embryos, using markers of different neuronal populations. To understand the mechanisms underlying miR-9 function, the interaction between miR-9 and selected in silico predicted targets will be tested, and an innovative microarray-based biochemical approach for identifying targets in vivo will be developped. The NEuromiR project also includes epistasis experiments to connect miR-9 action with that of other neurogenesis regulators (Rest, Her) expressed in progenitors. Finally, in a longer term and to extend the findings to later developmental stages and adulthood, zebrafish transgenic lines that enable to conditionally enhance or deplete miR-9 function will be engineered. Together, this project will shed light onto the fine-tuning of neurogenesis control by microRNAs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Defining Clinical and Molecular Phenotypes of Multi-Drug Resistance in difficult to treat Rheumatoid Arthritis' (MDR-RA), addressing dissemination and exploitation.

assistant: **Impact**

Rheumatoid Arthritis (RA) is the most common, chronic, inflammatory joint disease with a prevalence of about 1% of the adult population (22M patients worldwide and 7M in EU) and estimated to be responsible for 10,000 disability adjusted life years (DALY's) costing EU society €55B annually. Despite aggressive therapy, about a third of patients have to give up work within 5 years of disease onset mainly due to lack of response to multiple disease modifying anti-rheumatic drugs (DMARDs), multi-drug resistance (MDR). Thus, the main objective of this proposal is to define the clinical and molecular phenotypes leading to MDR in RA patients to prevent when possible or, when not possible, optimise the management of these patients. MDR-RA is highly relevant to the program, as these patients are often disabled, unable to work and paying a high personal and societal burden. Moreover, MDR-RA is under-researched and the underlying pathobiological mechanisms for resistance remain unknown, while as we have no predictors of therapeutic response to any of currently available drugs, inevitably treatment is based on trial-and-error. MDR-RA has the ambition of transforming care for these patients and deliver significant advances beyond the state-of-the-art methodologies, as for the first time, molecular pathology will be integrated into clinical, psychosocial, pain perception and imaging profiling in existing clinical cohorts to develop truly holistic predictive models for future clinical use (iCare-RA). The transformative potential of iCare-RA will be tested in a prospective randomised trial in comparison with routine standard of care, while its future implementation potential will be assessed through an early economic modelling. Finally, a strong management and dissemination strategy wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The speed of molecular evolution: rate shifts, gene function and natural selection in primate history' (2007-2013).

assistant: **Innovation**

Which genes have shifted in evolutionary rates during the history of the Primates (monkeys, apes and humans); and what does the function of these genes tell us about adaptation in our Order? The aim of this proposal is to investigate changes in the speed of primate gene evolution, using complete genome sequences from at least six species of Primates augmented by data from other species in the Order, including Neanderthals. The specific aims of the proposal are i) to identify functional classes of genes (e.g. cognition and immune system) whose rates of evolution diverge from general trends in primate gene evolution, ii) to build a picture of the gene functions that characterise human evolution integrated over the 20,000 to 25,000 human genes, and iii) to relate these functional classes to selective processes at the level of primate ecology (e.g. parasitism, predation, mating system and social behaviour). The work will require novel bioinformatics and comparative methods that can identify genes whose evolution varies in rate and mode throughout the primate tree, and these be developed and made freely available to other scientists. By building on a wider set of species and genes than previously studied the results of the research will provide the first “whole genome functional map” perspective of the conserved and altered gene functions occurring during the evolution of the lineage leading to modern humans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Development of multi-step improved epidermis-specific vaccine candidate against HIV1/AIDS'.

assistant: **Concept**

More than 60 million people are infected with HIV1, mostly in non-developed countries, and there is an urgent need for effective affordable treatment of HIV1 infections. The main objective of the project is to develop an efficient genetic vaccine candidate for therapeutic and preventive use against HIV/AIDS. This vaccine should be capable of inducing cell-mediated and humoral immunity against virus and virally infected cells in different phases of virus life-cycle. DNA vaccines could fulfil these requirements if rendered more efficient. To this aim, we will use the combination of complementary technologies brought in by four SMEs.The novel DNA vaccination technology will combine:(i) the restricted expression of the multi-epitope/multivalent HIV antigens in specific cells of the epidermis;(ii) a micro-needle array based injection device for reproducible and efficient delivery into the epidermis;(iii) the EPI-GTU® technology that allows strong and long term expression using segregation/partitioning function of the Bovine papillomavirus type 1;(iv) the plasmo-VLP® technology that allow to express the immunogens within and onto virus-like-particles;(v) the adjuvant effect of different cytokines.The step-by-step combination of these technologies will be evaluated in the laboratories of the three academic partners by state of the art methods. The initial evaluation of vaccine efficacy will be performed in mice and pigs, and will be ultimately validated in cynomolgus monkeys. EPIVAC aims to conduct its pre-clinical development up to the GMP production and testing of vector batches that will be ready for evaluation in clinical trials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Definition of methods to protect conifers from insects compromising forest survival and regeneration in the mountain areas of South-Western China', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The main objectives are as follows:* To understand the reasons why the bark beetle Tomicus piniperda causes heavy damage in Yunnan pines (Pinus yunnanensis), while its economic impact stays at low level in Europe.* To establish an inventory of the main cone and seed insects in Yunnan and to study their relations with host trees.* To measure the incidence of seed damage by insects and assess the effect on the natural regeneration of the main conifer species in Yunnan.* To define integrated control methods against T. piniperda and the main cone pests in Southwestern China.* To define conditions to be respected in Europe, to avoid T. piniperda to become dangerous.* To train Chinese scientists and engineers to research and control techniques on forest pests, and to enlarge the European experience in that field.Expected OutcomeExplanation of the reasons for the damage by T. piniperda in SW China. Generality of the European model of conifer-bark beetle-fungi relationships. Definition of targets for control of bark beetle damage in SW China. Definition of possible attractants. Definition of possibilities to improve tree resistance. Elaboration of bark beetle risk prediction models. Inventory and incidence of cone and seed insects on conifer forests of SW China. Definition of attractive visual traps baited with volatiles for cone and seed insects. Finally, proposition of integrated control methods against bark beetles and cone and seed pests in SW China.The key activities envisaged are:* Comparison of T. piniperda ecology in China and in Europe, by focusing on the shoot feeding part of the beetle life cycle (beetle dispersal, attraction).* Identification of the phytopathogenic fungi associated with T. piniperda and definition of their role in beetle population establishment. Me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Social Telemedia Environment for Experimental Research' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Social media already influence social relationships thus changing social structure enabled by technological advances. These advances transform the environment(s) we are surrounded by, as they introduce new kinds of interactions between humans and objects. It is therefore natural for users within this emerging social cyberspace to demand the kind of experiences they are accustomed to in their daily lives with the community type of communications being at the central stage. STEER will address this community-centric digitally-based ecosystem which we refer to as Social Telemedia", a cross-breeding of social networks and networked media. Social Telemedia will further intensify current societal practices and habits and they will flourish on a new network middleware framework that will combine Social Informatics and Content Delivery. Social Informatics loosely refer to any digitized information that is generated or exchanged in the context of social networking whereas content delivery represents the communication medium through which social informatics are exchanged, only this time content could be delivered through a bundle of synchronised and heterogeneous flows to a community of users. The overall objective of STEER is to make significant advances in Social Telemedia research and practices, and engineer an operational Social Telemedia environment customized to support various innovative experiments. These experiments are oriented toward investigating the intrinsic nature of the Future Social Telemedia Lifecycle that revolves around communities, revealing new properties and patterns, creating new insights, and, exploring the synergy between Social Informatics and Networked Media delivery and its impact on user experience. To achieve this objective STEER will contribute new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Ultra low emission vehicle-transport using advanced propulsion'.

assistant: **Objectives**

Regional passenger transport is a rapidly growing market in Europe, as a result of the need to minimise pollution in cities by reducing the demand for personal transport. Persistent requirements for mass transport include: reduction in investment cost, minimisation of emissions, reduction of maintenance costs, and improvements in energy efficiency. As the cost of electrification is often unacceptably high, diesel powered vehicles are still the only remaining alternative. However, the maintenance costs associated with the diesel engine are very high, while frequent stop/start cycling on suburban routes results in high levels of noxious ernissions and reduced energy efficiency. The objective of this project is to develop a hybrid powertrain, comprising a gas turbine engine which is directly coupled to a high speed generator, a flywheel and power electronics for traction and regenerative braking. The complete system, under the authority of a supervisory control unit for safe and efficient operation, will be installed in a suitable vehide. The prototype vehicle will then be tested for its safety, environmental acceptability, performance, functionality, operability, maintainability, and reliability. This will establish proof of concept. The project will aim to show clear performance targets that would make this drivetrain an attractive and practical solution for a wide range of mobile applications in addition to urban transit vehides. The project will also perform a detailed comparison of competing technologies, including diesel power, diesel electric hybrid and pure electric. This will be done on the basis of performance (acceleration, emissions and efficiency), cost of required investment and maintenance costs. The overall project achievements are reduction in investment c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Determinants of mammalian transcription start site selection and core promoter usage'.

assistant: **Objectives**

Understanding the mechanisms underlying the initiation and regulation of transcription remains one of the most fundamental questions in biology. Much of what we know about the transcription process was inferred from experiments on a handful of genes. As these experiments are not realistically scalable, corresponding computational methods building on these findings have emerged; however, these are not accurate enough for annotation of genomes. The limitations reflect that we have no accurate universal model describing transcription initiation; to a large extent, our understanding is based on case stories. Recently, high-throughput methods have been developed to chart the TSS landscape with nucleotide resolution. Using these data, I have dissected promoters at nucleotide level and found patterns that explain the transcription initiation rate for individual nucleotides. The objective for this work is to extend this to the first universal model for how cells select core promoters and associated TSSs. This will have two counterparts: i)prediction of TSSs from DNA sequence given a region of accessible DNA, and ii)prediction of DNA accessibility based on DNA sequences and dynamic epigenetic factors. Such a model will be a corner stone of future experimental and computational transcriptome and gene regulation studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innovative Biodegradable PLA Plastic for an Increased Range of Packaging Applications' in the context of a Horizon 2020 call.

assistant: **Objectives**

Bioplastics are an essential part of our efforts to reduce pollution and increase sustainability. Of these, the most ecoefficient bioplastic is PLA as it is biodegradable, requires 50% less energy and produces 10 times less emissions in comparison to standard thermoplastics like PET and PP. Furthermore, as it does not need to be recycled, it not only saves the energy and cost involved, but also the fact that only a fraction of the plastic produced reaches the recycling plant, the rest ending up in landfill or the sea.However, biodegradable plastics only make up approximately 0.2% of plastics produced in 2014. This is because conventional PLA has certain technical limitations which reduce the number of marketable applications where it can be used. For example, it cannot compete with standard thermoplastic grades used in packaging applications (such as PET and PE), in terms of oxygen and water vapour barrier and thermal properties, which are the most demanded properties for packaging requirements.Advanced & Functional Technologies for Biocomposites S.L (ADBIOCOMPOSITES) has developed an innovative, biodegradable PLA grade named BlockPLA which has enhanced technical properties: oxygen and water vapour barrier, thermal stability, transparency and flexibility. BlockPLA solves the drawbacks that PLA currently shows for packaging applications. In addition, BlockPLA has food contact approval and requires less energy to be produced. Production costs are slightly lower than conventional PLA.Therefore, BlockPLA is a real biodegradable alternative to PET, PP and PLA for packaging applications in the food and beverage industry, pharmaceutical and biomedical industry, home care packaging, cosmetics industry and others.ADBIOCOMPOSITES aims to use the SME instrument to scale up the pro