RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Establishment of embryonic stem cells and gene targeting technology in rats for investigation of the genetic basis of cardiovascular disease', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The objective of this programme is to facilitate the use of homologous recombination in the rat. The long-term aim is achieve a better understanding of the role of specific genes in normal and abnormal blood pressure regulation.The rat is the species of choice for many areas of biomedical research, including hypertension and neurobiology, however existing techniques of germline modification in this species are limited. Although it is technically possible to produce transgenic rats by DNA microinjection, the ability to introduce precise genetic alterations is severely limited by the lack of suitable embryonic stem cells. To date all attempts to isolate such cell lines have not resulted in successful germline transmission. Further efforts and new approaches are therefore required to obtain suitable cell lines. Our aim is to develop a generic method of ES cell derivation through a selection-based approach in order to extend stem cell technology into this species. If the selection methodology is successful this would eventually permit germline manipulation of existing phenotypically selected models of hypertension such as the Spontaneously Hypertensive Rat (SHR), and would enable the future developments to other rat strains of interest to biomedical researchers studying of human disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrable Structures in theory of multi-phase flows' (INTERFACE) targeting Sixth Framework.

assistant: **Abstract**

In recent years, integral structures have been found in a class of hydrodynamics problem leading to pattern formation in a regime far from equilibrium. Growth problems of this type, Laplacian Growth or Hele-Shaw problems, refer to dynamics of a moving front between two distinct phases driven by a harmonic scalar field. These problems have been primarily approached using asymptotic and complex variable methods to address both their stable and the notoriously unstable versions. The relation between the Hel e-Shaw problems and theory of integral systems is an exciting emerging research area. We also mention that it has recently been shown that there is a connection between the two free- boundary problems above and that of the support of Eigen values of an ensemble of large random normal matrices. We intend to explore this aspect of the problem in conjunction with the integral system approach. The aim of the project is two-fold: to address basic questions in the theory of unstable interfaces and multiphase flows, combining recent achievements in the theory of integrable systems with asymptotic and complex-analytic approaches. Connecting and generalizing three subjects of Hele- Shaw problems, theories of integral hierarchies and matrix models, we expect to advance under- standing of interface dynamics and account for its basic physical features. Vice versa, using the theory of interfaces, we illustrate and develop physically important integral models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SOCIETY, METALLURGY AND INNOVATION: THE IBERIAN HYPOTHESIS' in the context of a Seventh Framework call.

assistant: **Objectives**

The SMITH project seeks to develop our understanding of the origins of metallurgy in Western Europe and its social impact as a starting point to facilitate comparisons on a Eurasian scaleIt capitalises on unprecedented access to key archaeological materials, availability of synergic projects and infrastructures at UCL, and a wholly interdisciplinary approach that amalgamates cutting edge archaeological science with sophisticated theorisation on the role of technology in societyThe main questions addressed are:-Whether metallurgy was independently developed in Western Europe-Its actual impact in social stratification processesA wide range of archaeological materials from key sites in Western Europe will be analysed by a myriad of techniques–XRF, SEM, ICP, Metallography, etc–involving interdisciplinary collaboration.The data will be interpreted in the light of the evidence known from Eurasia and especially of the current UCL-lead project on the origins of metallurgy in the BalkansSMITH brings an original perspective as it will refocus the debate on the origins of metallurgy, and because of its comprehensive dual concern:on the one hand it includes all the steps of the metallurgical process (mining, smelting and shaping but also consumption);on the other hand, it approaches metallurgy as part of a myriad of dynamic human activities and relationships in specific and changing social contextsThe study of the whole diversity of the archaeometallurgical and archaeological record is anchored in a concern with how societies assimilated metallurgy and developed different metallurgical traditions, and to what extent those processes were influenced by social contactsAs a whole, SMITH aims to be on the cutting-edge of existing efforts to produce reliable data and original interpretat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mechanical Biomarkers for Prediction of Cancer Immunotherapy' under Horizon 2020.

assistant: **Concept**

Immunotherapy has revolutionized the treatment of multiple cancers and has already become a standard of care for some tumor types. However, a majority of patients do not benefit from current immunotherapeutics and many develop severe toxicities. Therefore, the identification of biomarkers to classify patients as likely responders or nonresponders to immunotherapy is a timely and of tremendous impact task. My hypothesis is that biomechanical aspects of the tumor microenvironment mediate resistance to immunotherapy. Specifically, many tumors stiffen as they grow and also, tumor growth within the host tissue generates mechanical forces, termed solid stress. Tumor stiffening and solid stress are distinct mechanical abnormalities that compress intratumoral blood vessels, causing hypo-perfusion and hypoxia. Systemic administration of immunotherapeutics requires a well-perfused vasculature, whereas hypo-perfusion and hypoxia promote immunosuppression, helping cancer cells to evade immune responses. The objective of the proposed research is the identification of novel Mechanical Biomarkers related to tumor stiffness, solid stress, perfusion and hypoxia for prediction of immunotherapy. Tumor-bearing mice will be developed and treated with immunotherapeutic drugs and clinically used methods will be combined with computational biomechanical modeling for measuring the Mechanical Biomarkers, making the research transferable to the clinic. The biomarkers will be benchmarked against tumor normalization strategies aiming to restore/normalize mechanical abnormalities and optimize immunotherapy. Finally, the clinical utility of the selected biomarkers will be evaluated in human tumors. Only few tumor-specific biomarkers are used in the clinic - based mainly on genomic analysis. This proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'crIpeC nAnomedicines’ micRodistribution in tUmour tiSsue' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cristal Therapeutics (CT) is an innovative SME based in the Netherlands dedicated to the creation of the next generation of targeted nanomedicines (NM). CT has developed CriPec, a nanoparticle technology that can entrap a wide range of drugs, transforming them into custom-made NM. CriPec-based products have demonstrated excellent pharmacokinetics and tumour accumulation as well as highly improved safety, both in laboratory and patient settings. However, the full therapeutic potential of CriPec has not been obtained due to a lack of understanding of its tumour microenvironment (TME) microdistribution and behaviour, hindered by the lack of highly specific (bio)analytical expertise within Cristal Therapeutics. ICARUS will enable CT to solidify its position as an innovative SME and provide them a competitive edge through hiring an Innovation Associate (IA). The envisioned IA will develop and implement state-of-art (bio)analytical methodologies (including advanced MALDI-techniques) that have not been exploited in the field of NM until now, and that will provide CT with essential insights that will guide the composition optimisation of all CriPec-based products. Furthermore, the ICARUS project is heavily focused around the training of the IA, thereby greatly improving his/her career development. A training programme tailored to his/her specific needs and personal career development plan will be developed, allowing the IA to: • Gain novel skills and experience on every aspect of the development of nanoparticles, encompassing the required multidisciplinary expertise from several fields;• Gain innovation and business related skills in a multidisciplinary setting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Design of a semi-hot process chain (DESPROCH)'.

assistant: **Innovation**

Hot Forging is a manufacturing process by which metal is plastically deformed under great pressure and high workpiece temperature into high durable parts known as forgings. The forged parts are used in areas where there is a demand for high quality and e xcellent mechanical properties combined with large batch sizes. Customer's demands are rising with regard to higher accuracy of manufacturing, surface quality and use of material. It is on the forges to respond to these pressures. Therefore it is necessa ry to support the European forging industry that mainly consists of SMEs, in the development an optimization of production technologies. Semi-hot or warm forging is an economical alternative to the conventional forging technology. It offers several adv antages that contribute to economic, environmental and social issues. These are reduced energy input, no scale, better surface quality and closer tolerances. It has been successfully used in the production of rotationally symmetric components so far. Com ponents in which one axis is several times longer than the others cannot be manufactured with this process by now. Main goal of this project is to establish a basis for the set-up of complete, reliable and flexible process chains for the semi-hot forgin g of long parts. It begins with the feeding of raw material and ends with the output of finished, cooled and measured parts. This is to be realized in the supporting SMEs in a one-piece-flow process with low production costs and high process quality and will guarantee an optimal use of the project results. The result expected from the proposed project is the spreading of the semi-hot forging technology first within the project participants but further on in the European forging industry as a whole and hence strengthening t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New concepts for turnouts in urban rail transit infrastructure (TURNOUTS)' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The project focuses on design & manufacture of new construction concepts of special track work for rail infrastructure that are: low maintenance, high quality, safer, risk mitigating & low noise. Complete turnouts will be considered in the research project (frog and switch area) with exclusion of control systems. At the start of the project, two different modelling procedures for impact force calculation during vehicle running in turnouts will be compared for their performance and validated. A first comparison will be made comparing measurement and modelling results on a reference turnout. Further refinement will be made by updating modelling results by means of measurement results on six different turnout systems which are representative forth conventional turnouts used today in urban rail transport networks (WP 1).Also at the start of the project large number of potential design measures for reducing impact forces will be defined. A conceptual design study of these design measures will be made (WP2).In the second phase of the project, 7 test sites will be selected (end-users) and for each test site the most optimal new turnout design will be developed (iterative procedure interims of refining selected turnout or in terms of selection a new turnout design) (WP3).The developed new turnout systems will be manufactured (WP4),tested in the lab and installed on site. This will include the use of new materials, new manufacturing techniques and new installation techniques. Their performance will be measured and compared against the calculated results (WP5).At the end of the project, conclusions will be drawn in work package 6.The consortium includes the main European turnout manufacturers, research and engineering partners, contractor and three end-users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'IDENTIfication and tracking of cancer-prone cells in KIdney Tubules' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Understanding what makes our cells prone to develop cancer is key for identifying effective strategies of tumor prevention. By analyzing the genome of normal human cells, I obtained compelling evidence that the pattern of somatic mutations can be used to identify the cell-of-origin of kidney cancer. Although every cell accumulates somatic mutations during a lifetime, some are exposed to a specific mutational process that leave a detectable mark in their genome. Kidney cancers and their cell-of-origin show the same genetic mark, consisting of excess somatic point mutations with unique characteristics and unknown origin. We plan to use this mutational signature to track cancer-prone cells in human kidneys and a) follow their population dynamics; b) study their genome and transcriptome at a single cell level; c) understand the underlying causes of excessive mutation. Having already established a non-invasive assay to detect cancer-prone cells in urine samples, we can now analyse numerous donors, longitudinally and without biopsies. Our preliminary analyses point to adaptation to low-oxygen conditions (hypoxia) as the likely cause of excessive mutation in kidney cells and suggest defects in specific DNA repair pathways as a mechanism. We will test whether overactivation of hypoxia signalling, caused by either a genetic syndrome or exposure to renal ischemia, induces the kidney-specific mutational signature in humans. We will then dissect the molecular mechanism by functional experiments in vitro and in mouse models. Finally, we will test whether and how the diet contributes to the expansion of the mutation-prone cell subset in mouse kidneys. Overall, this study will provide unprecedented resolution of early events leading to kidney cancer initiation and will determine wheth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Water – Electricity – Telecommunication Package' (WETPaC), addressing dissemination and exploitation.

assistant: **Impact**

Clean water, electricity and communication are crucial for human well-being and sustainable socioeconomic development.  Their provision is in deficiency in most rural areas of the world and in specific Mediterranean areas of Europe.  Yet, solutions for the above needs are developing very slowly due to lack of funds and the risks associated with payments for the supplied services.The proposing SME aims to develop and demonstrate an optimised packaged system (WETPaC) to provide these services in a low carbon, energy efficient and sustainable way.  Key to overcome the relevant barriers is the development of a remote maintenance and operation system as well as the introduction of smart payment methods for electricity and water.The innovative aspects of WETPaC will facilitate its financing.  This will lead to the involvement of local entrepreneurs who will develop a sustainable business in selling electricity, water and services (e.g. electricity, air conditioned shelters, etc.) to telecom companies.The main objective of the proposed project is to perform a feasibility assessment and a detailed business plan for the successful implementation of WETPaC.Based on the results of “Phase1”, the proposing SME plans to develop and demonstrate a prototype with the help of investors and/or “SME – instrument – Phase 2”.WETPaC will address a global challenge based on European design, components and equipment.  Successful commercialisation will provide valuable services that will improve quality of life and will consequently help develop new jobs in Europe as well as in developing countries.The feasibility study will have as priority the Greek islands where it is suitable for touristic businesses and Philippines where it can supply villages.  Other countries will be also examined.During
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CAse studies on the Development and Application of in-Silico Techniques for Environmental hazard and Risk assessment' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Implementation of REACH requires demonstration of the safe manufacture and use of chemicals. REACH aims to achieve a proper balance between societal, economic and environmental objectives, and attempts to efficiently use the scarce and scattered information available on the majority of substances. Thereupon REACH aims to reduce animal testing by optimized use of in silico and in vitro information on related compounds. The REACH proposals advocate the use of non-animal testing methods, but guidance is needed on how these methods should be used. The procedures include alternative methods such as chemical and biological read-across, in vitro results, in vivo information on analogues, (Q)SARs, and exposure-based waiving. The concept of Intelligent Testing Strategies for regulatory endpoints has been outlined to facilitate the assessments. Intensive efforts are needed to translate the concept into a workable, consensually acceptable, and scientifically sound strategy. CADASTER aims at providing the practical guidance to integrated risk assessment by carrying out a full hazard and risk assessment for chemicals belonging to four compound classes. A DSS will be developed that will be updated on a regular basis in order to accommodate and integrate the alternative methods mentioned above. Operational procedures will be developed, tested, and disseminated that guide a transparent evaluation of four classes of emerging chemicals, explicitly taking account of variability and uncertainty in data and in models. The main goal is to exemplify the integration of information, models and strategies for carrying out safety-, hazard- and risk assessments for large numbers of substances. Real risk estimates will be delivered according to the basic philosophy of REACH of minimizing animal tes