RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Identity Management in PUbLic SErvices'.

assistant: **Objectives**

Public services (as all others) are reaching the Digital Single Market (DSM). Secure and respectful electronic identity (eID) management is an important enabler for trust and confidence in the DSM. Emerging technologies can disrupt eID and have strong potential for empowering existing initiatives. In particular, IMPULSE focuses on 2 of the most promising and disruptive technologies nowadays: Artificial Intelligence (AI) and Blockchain, and their contributions to and impacts on eID.IMPULSE will carry out a user-centric and multidisciplinary impact analysis on the integration of Blockchain and AI on eID in public services, evaluating benefits but also risks, costs and limitations, considering socio-economic, legal, ethical and operational impacts, together with framework conditions (like GDPR and eIDAS regulations, existing eID systems, and standards).IMPULSE will use a demand-driven co-creation process as the guide, including pilot-oriented operational experimentation and involving Digital Innovation Hubs. A set of 6 representative and innovative case studies in Denmark, Spain, Bulgaria, Iceland and Italy, led by public service partner, will provide a variety of cultural, operational, legal, procedural and social contexts for research. Two major outcomes will be produced:1) Holistic AI and blockchain technology supporting GDPR-compliant eID to complement existing EU identity schemas, ensuring cross-border access and secure and adaptable requirements for actionable integration with other public service providers, and adoption by existing Trust Service Providers (TSP) to ensure marketability.2) Actionable roadmaps (detailing pathways and good practices) for the adoption, escalation and sustainability of such advanced eID technologies by public services in the EU ecosystem,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Unlocking natural behaviour studies with standard two-photon microscopes' (NeuroBRIDGE) targeting Horizon Europe.

assistant: **Abstract**

Two-photon (2P) microscopy is one of the most widely used tools in neuroscience to study neuronal activity with single-cell resolution. Yet, current 2P systems are largely restricted to head-fixed animals, limiting the scope of behavioural studies. To overcome this barrier, we have recently developed a novel fiber-based miniaturized approach that enables high-resolution 2P optical studies in freely moving animals. This proposal aims to transform this innovation into a robust, user-friendly platform that can be easily disseminated, thereby widening access to freely moving 2P experiments.Our objective is to design and assemble a compact fiber-based module and validate its functionality and potential through proof-of-principle neuroscience experiments in freely moving behavioural paradigms.In parallel, we will establish an intellectual property strategy and engage with industrial partners to accelerate commercialization. By enabling widespread access to naturalistic behavioral studies, this technology will expand experimental possibilities, allow institutions to upgrade existing equipment at reduced cost, open new product lines for industry, and ultimately advance understanding of brain function and neurological disorders.


**Keywords:** Two-photon microscopy, fiberscopes, micro-endoscopy, optical brain imaging, neuronal circuits, imaging in freely moving animals, calcium imaging, optogenetic photostimulation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Clinical Validation of a Novel Biomarker for the Prediction of Bone Metastasis in Early Stage Breast and Prostate Cancer' to be submitted under Horizon 2020.

assistant: **Abstract**

OSTEOMET is a new and proprietary test based on IHC and FISH technologies that addresses the unmet medical need of selecting patients at risk of bone metastasis in breast and prostate cancer. OSTEOMET is based on an innovative single biomarker whose expression levels in primary tumour tissue are highly associated to bone metastasis. OSTEOMET will lead to an improvement in clinical practice, improved prognosis and personalized therapy of patients with breast and prostate cancer, with a large positive impact on the economic efficiency of health care operators. The OSTEOMET project has previously been evaluated as a stage 2 project, reaching the threshold on each criterion (> 4/5). We now have decided to take one step back to address existing gaps via a phase 1 proposal. Since the clinical utility of OSTEOMET will depend on the outcome of the clinical validation studies, we envision a number of scenarios for positioning OSTEOMET in the market. This phase 1 proposal will deliver a clear roadmap for achieving the commercialization of OSTEOMET in either of the different scenarios. We will perform expert interviews and map out various aspects including the clinical validation track, the regulatory path, target user specifications, an assessment of the EU and US market and reimbursement environment and a strategic approach to drive clinician adoption and payer acceptance to optimize market penetration. Our elaborated business plan will include a strategy to establish partnerships with Diagnostic or Pharma companies as well as the value created for Inbiomotion in each scenario. We trust that the current project will fill in the gaps supporting the business feasibility of marketing OSTEOMET as a new diagnostic kit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'innovative Systems for Personalised Aircraft Cabin Environment'.

assistant: **Concept**

The focus of this proposal is to improve passengers’ comfort and well-being while fulfilling specific human needs in the treated case ""living environment in an airplane"". To address the individual passenger and her/his needs this will be done in the frame of an individual and innovative seat environment. Thus passengers’ choice with regard to comfort will be increased directly. Therefore, iSPACE will provide concepts and step-change technologies in order to reach a revolution in personalised passenger climate control. The overall aim of iSPACE is to provide aircraft manufacturers and suppliers with know how and innovations to address the individualisation of the cabin environment. This will ultimately provide a step-change in passenger comfort during flight. Furthermore, validated tools for the simulation of individualised cabin environment will be developed. The scientific and technological objectives of iSPACE are to: Develop concepts for individualisation of passenger cabin environment and prove its general feasibility. Develop and prove emerging step-change technologies for individualisation of passenger cabin environment.  Provide simulation tools for individualised cabin environment and give recommendations for existing and future commercial aircraft. iSPACE is in line with former projects funded by the EC which investigated the cabin environment with a philosophy on human centred design. So far most of these projects did investigate the current status (HEACE) and/or studied the impact of environmental parameters on the human perception of cabin comfort (FACE, ICE). Recommendations for future technological developments are on the way to be set (ICE). Thus only fields of development have been explored and problems have been identified. One way of addressing these
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The role of Microbes in Aquaculture: understanding the functional role of oyster microbiomes in response to changing climates and diseases' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Bivalves are ecologically and economically important in Europe. Oysters in particular provide ecological benefits through habitat provision, economic benefits through aquaculture production, and societal benefits through cultural associations. Although of high importance, oyster production is threatened by changing climates and disease proliferation which cause mass mortality events. Recent advancements show that microbiomes, the microbial community within a host organism, play a significant role in the functioning of the host and their resistance to adverse conditions. This project will incorporate knowledge from the fields of global change ecology, shellfish health and diseases, and microbiology to increase the understanding of the role of the oyster microbiome in resistance to threats posed by climate change and disease proliferation, as well as the overall performance of oysters in the environment. By combining field and laboratory investigations of how the physical environment affects microbial functioning within oysters produced by both wild and hatchery based stocks, and subsequently their susceptibility to pathogens, this project will provide a holistic, in-depth understanding of the contribution of such microscopic organisms to these valuable bivalve species. Results will be beneficial to the scientific community, aquaculture stakeholders, policy makers, and coastal societies alike. Project outcomes will move forward the integration of microbiology into the success of aquaculture to increase production, sustainability, and blue growth.


**Keywords:** Functional metagenomics, microbiomes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Development and control of PrPSc-based tests in humans and animals using cerebrospinal and brain tissue'.

assistant: **Concept**

This proposal aims at improving and controlling techniques in the diagnosis of BSE in humans and animals. For that purpose two techniques have recently been developed, one of which, the paraffin-embedded tissue blot (PET blot) technique for prpSC has proven most sensitive in post mortem brain material and will be used to validate conventional immunohistochemical methods. The other technique uses fluorescence correlation spectroscopy (FCS) to detect seeded multimerization of prion protein molecules in the cerebrospinal fluid (CSF).1. Currently, transmissible spongiform encephalopathies are most reliably diagnosed using histopathology, immunohistochemistry and Western blotting to detect the pro/ease-resistant prpSC in post-mortem brains. The histoblot technique, which requires fresh unfixed tissue, is superior in sensitivity to immunohistochemistry of formalin-fixed and paraffin-embedded CNS material. This is unfortunate since in the majority of cases, be it in veterinary or human pathology, formalin fixed tissue may be the only tissue available for immunohistochemistry. We have therefore developed a technique which combines the advantage of high sensitivity of tissue blotting (Western or histoblot) and the advantages of paraffin-embedded material, i.e. the high anatomic resolution and ample availability of tissue samples. This technique, which we have termed the paraffin-embedded tissue blot (PET blot), surprisingly is at least as or even more sensitive than the histoblot technique. The technique has been successfully employed for the investigation of human and some animal variants of prion disease. Since it takes at least one week to perform, it will not be used to test meat for human consumption; however, it will be most useful in validating other techniques and in ret
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Palliative care in Europe: ethics and communication' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

OBJECTIVES* Examine the importance of effective communication and the moral significance of truth telling in the palliative care setting within a European context.* Seek an explanation of Europe wide differences by examining skill levels as well as looking at social. professional and cultural determinants.* Produce a set of culturally sensitive teaching materials which would facilitate the development of communication skills across Europe whilst taking account of justifiable differences with respect to the core issue of truth-telling and disclosure.This project addresses the ethical issues relating to communication within the context of European palliative care services. The project will analyse the moral arguments which ground a commitment to effective communication and truthfulness within health care more generally, and then consider why there might be particular reasons supporting a special commitment to each as they relate to the delivery of palliative care. Ethical analysis will be informed by a thorough survey of the empirical evidence relating to the effect of good or bad communication on patient and family well-being and staff performance. If it is thought appropriate the skills of the participants will be harnessed to complement existing research data. A small-scale qualitative study has been planned, and will be executed if the meta-analysis of existing studies suggests that it is required. Having investigated the basic issue of truthfulness, the analysis will them focus on the specific issue of disclosure of information? This analysis will be conducted against the backdrop of widely differing attitudes and practices within Europe, which exist despite the fundamental philosophy of care formulated by the founders of the palliative care movement. This philosophy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Engineering next-generation fusion proteins to dress the cell membrane with functionally enhanced receptors' (DRESSCODE) under Horizon Europe.

assistant: **Objectives**

No drug can be effective without an appropriate delivery system; this is why the development of formulations for effective and safe drug delivery currently raises major interests, in all clinical applications. While the use of therapeutic proteins has substantially increased in the last four decades, there is an entire class of proteins that has not yet been explored as drugs: the transmembrane receptors. In fact, the delivery of receptors for clinical applications remains very challenging and has only been achieved via genetic engineering of cells, referred as gene therapy. To date, most gene therapies remain extremely expensive and therefore, poorly accessible to patients.DRESSCODE proposes to innovate cutting-edge protein engineering technologies to deliver and enhance receptors at the cell membrane, using recombinant proteins only. By doing so, we aim to create a paradigm shift from genetic engineering to protein engineering of the cell membrane, with the ambition of developing cost-effective protein-based therapies.In DRESSCODE, we will first engineer independently the extracellular, intracellular, and transmembrane parts of a receptor, before combining our technologies to reconstruct functional receptors with enhanced bioactivity. Particularly, we will generate fusion proteins that 1) target the cell surface with super-avidity, to enhance receptor sensing; 2) penetrate the cell membrane and target its inner side, to enhance receptor signaling; and 3) insert across the cell membrane to reconstitute the receptor transmembrane domain using pH-low inserting peptides.DRESSCODE will demonstrate Proof-of-Technologies in two high-impact clinical applications, focusing on the engineering of VEGFR-2 for therapeutic angiogenesis and of the CAR for T cell-based cancer immunot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Physics of fruit and vegetable tissue in postharvest handling.', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Two research groups, intensively collaborating in the Department of Agro-Engineering and -Economics of the Catholic University Leuven (Belgium) jointly offer a training site for doctoral fellows in the area of post harvest technologies : the Laboratory for Agro-Machinery and -Processing and the Laboratory of Post harvest Technology. These research groups carry out applied and basic research in the area of post harvest physiology, technology and quality of fruits and vegetables:- basic research on techniques for non-destructive testing of fruit quality (e.g. acoustic impulse response, NIR)- analysis and modelling of transport phenomena (e.g. heat and mass transfer, gas diffusion, moisture transport)- basic research on microscopic and macroscopic physical properties of fruit Both groups are experienced in mathematical modelling and use numerical techniques such as the finite element method to model fruit quality changes. The Agro-Machinery research group has a complementary experience in vibration analysis and simulation with respect to vibration damage. The Marie Curie fellows will have the opportunity to be trained in each of those research areas, and will have access to an advanced research infrastructure with several state of the art experimental devices for measuring optical and macro- and microscopic physical properties of fruits. They will participate in advanced finite element analysis and modelling of vegetative tissue behaviour under mechanical loading, based on the results of experiments on a macro- and microscopic level. They will have the opportunity to attend one or more lecture modules of the complementary and advanced studies in post harvest and food preservation engineering, which is at doctoral level. Fellows should hold a master diploma of mechanical, e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'KINDOW – Intelligent Sun-tracking for Vertical Blinds' (KINDOW) targeting Horizon 2020.

assistant: **Abstract**

Kindow BV is a spin-off of Delft University of Technology (TUDelft) by bright minds with a passion for sustainable innovation through pragmatic thinking. Sunlight offers the perfect alternative for powering and improving buildings, allowing them to become more energy-efficient and more comfortable to live and work in. The Kindow project enables building managers to save energy and increase comfort by offering intelligent automation for motorized blind systems. It optimizes solar influx with automated positioning of the blinds to save on heating, cooling and lighting. Kindow offers automated integrated solutions that facilitate the transition towards a brighter future with the help of the sun. Kindow seeks to optimize the use of sunlight, in order to create healthy and productive workspaces and improve the energy efficiency of buildings. Kindow optimizes solar influx with automated positioning of the slats of the blinds to save on heating, cooling and artificial lighting resulting in a reduction in energy consumption (up to 25%). Moreover, Kindow provides increased comfort inside the buildings, which leads to increased wellbeing (visual comfort, thermal comfort and access to natural daylight), and a higher productivity (>5% annually). The global smart shade devices market is expected to grow with a CAGR of approximately 90.4% during 2016-2023, reaching €16.7 billion by 2022. Accordingly, we foresee a cumulated profit of 6.1 M€ by 2024 with a ROI of 2.88.