RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'COgnitive RAdio for SATellite Communications' in the context of a Seventh Framework call.

assistant: **Objectives**

The CoRaSat project aims at investigating, developing, and demonstrating cognitive radio techniques in satellite communication systems for spectrum sharing. Outcomes of the study will drive the definition of strategic roadmaps to be followed by industry stakeholders, European Institutions, and Governmental actors towards regulatory and standardization groups in order to ensure that the necessary actions are undertaken to open new business perspectives for SatCom through cognitive radio communications in support of the Digital Agenda for Europe.Flexible spectrum utilization is a surging trend for the optimized exploitation of spectrum resources, and the cognitive approach has already demonstrated its potential for terrestrial systems, but not yet in the SatCom domain. However, SatCom are fundamental to achieve the challenging objectives of fast broadband access for everyone by 2020: their inherent large coverage footprint makes them the most suitable access scheme to reach those areas where deployment of wired and wireless networks is not economically viable.CoRaSat puts together these two elements by considering Cognitive Radio approaches for coexistence scenarios in spectrum allocated to any SatCom service.For the first time in SatCom research initiatives, CoRaSat will systematically and thoroughly approach the Cognitive Radio concept considering SatCom peculiarities and characteristics.  CoRaSat will identify scenarios and use cases, focusing on broadband applications and considering other services, like interactive broadcasting, narrowband applications, etc., where cognitive radio can improve spectrum exploitation. Technology enablers for the identified scenarios will be developed and demonstrated for specific use cases through analysis, simulation, and testbed imple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A Europe-wide thematic network supporting a sustainable future for EU dairy farmers' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

EuroDairy will foster development and dissemination of practice-based innovations in dairy farming on key sustainability issues for the post-quota era. Work Package 1 (Project co-ordination) oversees formation of the Thematic Network, ensures interconnectivity in generation, capture and demonstration of innovation and best practice, and reports project outputs including recommendations for further innovation-driven research. WP 2 (Network of innovating pilot farmers and Knowledge Transfer Centres) establishes a community of innovating dairy farmers which through experience and practice on their own farms, bring good ideas and implementable solutions to EuroDairy. The farms participate in regional multi-actor operational groups, and connect as a network to share knowledge across borders. WPs 3-6 focus on four key topics - Resource efficiency, Biodiversity, Animal care, and Socio-economic resilience. These WPs provide leadership, direction and technical expertise for the exchange of innovative thinking, tools, technologies and best practice across the thematic network (pilot farmers, Knowledge Transfer Centres, and regional operational groups). WP 7 (Synergies in scientific and practice-based knowledge) draws from WPs 3-6 to capture new insights from combining science with practice-based knowledge, including benefits and trade-offs in solutions identified. WP 8 (Production and communication of end-user materials) implements a mix of novel and tried-and-tested approaches to internal and external communications. A diverse range of end-user outputs will be produced, made widely accessible to farmers.  EuroDairy supports H2020 objectives to increase productivity, improve competitiveness and impact less on the environment. Involvement of dairy levy bodies, farmers’ organisatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Unraveling tuft cell receptors and effector biosynthesis through interactome analysis' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Complex organisms rely on specialized organ structures to interact with their environment, facilitating vital exchanges of molecules. The same structures create vulnerabilities to colonization by microorganisms, requiring sophisticated defense mechanisms. Central to these defenses is the innate immune system's ability to detect and rapidly respond to pathogens through diverse sensor mechanisms. While significant progress has been made in understanding the detection of viruses, bacteria, and fungi, critical gaps remain in how the innate immune system detects large, multicellular parasites like helminths, which pose substantial health challenges to humans and livestock.Tuft cells, rare chemosensory epithelial cells in mucosal epithelia, play a critical role in initiating type 2 immune responses in crosstalk with group 2 innate lymphoid cells. Tuft cells secrete effector molecules such as IL-25, cysteinyl leukotrienes, and acetylcholine, orchestrating defense mechanisms against helminths. While the tuft cell response to microbe-derived succinate is mediated by the GPCR SUCNR1, this pathway is dispensable for helminth detection. Thus, the central questions remain: how do tuft cells sense the presence of helminths, how are these inputs integrated, and how are they converted into distinct effector outputs? This proposal addresses three key objectives: 1) developing innovative tools to track tuft cell activation and effector molecule release; 2) employing orthogonal approaches to identify tuft cell agonist-receptor pairs by combining interactome studies with screens for helminth-derived molecules; and 3) dissecting protein networks controlling distinct tuft cell outputs. By applying cutting-edge methods in innovative ways to mouse and human tuft cells and integrating newly dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'GEOARCHAEOLOGY, PALEOENVIRONMENTS AND LUMINESCENCE GEOCHRONOLOGY IN THE EASTERN ALPINE REALM AND SOUTH AFRICA DURING THE LAST GLACIAL CYCLE (115-11 ka)'.

assistant: **Objectives**

The last glacial cycle included some of the coldest and most unstable moments of the last 2 million years of Earth history. Climate-driven environmental changes impacted on the landscape and also influenced human evolution, dispersal and culture; they may also have played a role in the extinction of the Neanderthals. Human/environment relations thus merit detailed research. Accurate chronologies for human activities and contemporaneous paleoenvironmental records are key requirements to sustain further progress in geoarchaeology and to improve our knowledge of the history of humankind.  Optically stimulated luminescence (OSL) dating is currently one of the most dynamic fields in geochronology. The single-grain approach, in particular, opens up new opportunities for dating materials that have hitherto been ignored. Pioneering work has shown that archaeological sequences in cave-mouth deposits can be reliably dated using single sand-sized grains of quartz.   The overseas host institution (U. Wollongong, Australia) is a world-renowned geochronology laboratory with recognised expertise in single-grain OSL dating. The applicant will join this group in an international and interdisciplinary project to examine the origin of modern human behaviour and the role of paleoenvironmental changes in landscape and human evolution in South Africa.   A carefully designed research agenda will enable single-grain OSL dating to be applied to selected archaeological sites and related paleoenvironmental records in the eastern alpine realm as part of the follow-up phase. We will develop high-precision OSL chronologies for archaeological and loess sequences, and match these to the paleoclimatic record of U-Th dated alpine speleothems. The improved chronological control will greatly assist archae
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'CAR-T cell therapy targeting carbohydrates in cancer' (SweetCAR), addressing dissemination and exploitation.

assistant: **Impact**

Major limitations in current immunotherapy success are low antigenicity of targeting antigen and tumor heterogeneity. Hence there is an unmet need for novel antigen targets that could potentially be expressed on many tumor types. Cancer express aberrant cell surface glycosylation patterns compared to normal cells. These tumor-associated carbohydrate-neoantigens can be targeted for tumor cell killing by antibodies and cytotoxic immune cells. Sialic acids cover cell surface glycans and frequently have altered expression on many types of carcinoma cells and correlate with cancer progression and/or metastasis. We aim to focus on targeting sialic acid containing carbohydrate-neoantigens using the chimeric antigen receptor T cell (CAR-T) immunotherapy approach. Current clinical CAR-T cells target mostly soluble tumors using CD19, BCMA and other non-cancer specific antigens that often suffer toxicity and side effects. Our universal anti-carbohydrate CAR-T approach could target many types of carcinomas with high specificity and safety, and could potentially reach patients rapidly.


**Keywords:** Immunotherapy, glycobiology, carbohydrate, antibodies, chimeric antigen receptor (CAR), CAR-T cell therapy, cancer, solid tumors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'CONTRACT: Conformal Calibration for Reliable AI-Based Wireless Communications'.

assistant: **Concept**

CONTRACT sets out to investigate a novel, theoretically principled, framework for the reliable  deployment of artificial intelligence (AI)-based black-box models in wireless systems. Given the highly non-deterministic patterns of traffic and connectivity conditions, AI is currently viewed as an essential technology to ensure the support of communication services with widely heterogeneous performance requirements, ranging from cloud gaming to Industry 4.0. However, AI ``apps'' are, by and large, black boxes, whose introduction within the larger wireless network raises critical concerns about reliability. These concerns are not addressed by the vast literature on AI for wireless systems, which adopts a standard ``train-and-deploy'' best-effort approach. The main goal of CONTRACT is to endow for the first time AI-based wireless deployments with formal reliability guarantees. To this end, CONTRACT will introduce novel methodologies for: (i) the offline calibration of pre-trained AI apps via hyperparameter optimization  prior to deployment; and (ii)  the online run-time monitoring of key performance indicators  and conflicts among simultaneously deployed apps. In CONTRACT, hyperparameter optimization and online monitoring will leverage contextual information describing traffic and connectivity conditions, as well as synthetic data from a digital twin, i.e., a simulator, of the wireless network. The research  will build on conformal prediction, a statistical framework for assumption-free calibration, and on prediction-powered inference as a mechanism for the reliable integration of synthetic data.  This project will lead to a reconsideration of the role of AI in the engineering of wireless networks from a potential reliability concern to a dependable part of the system.


**K
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A Humanized Monoclonal Anti-Claudin1 Antibody (anti-CLDN1 mAb) for Treatment of Hepatocellular Carcinoma (HCC)' (HCC) under Horizon 2020.

assistant: **Objectives**

Hepatocellular carcinoma is the most frequent primary liver cancer and owing to its very aggressive nature is amongst the leading cause of cancer mortality worldwide (IARC). The number of liver cancer-related deaths in Europe in 2018 amounted to 77 375, and this number is expected to keep rising, reaching an estimated number of more than 100 000 deaths in 2040 (IARC). Major causes include the hepatitis B and C viruses, alcoholism, Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis. All of these medical conditions trigger liver fibrosis by damaging the liver and are closely associated with the development of HCC. As a matter of fact, more than 80% of HCC develop in fibrotic or cirrhotic livers. Early stages of liver cancer do not usually produce symptoms, and many challenges are associated with the screening of HCC, leading to its late diagnosis. The absence of effective drug treatment for HCC makes its resection the first curative option with most of the patients experiencing HCC recurrence within 5 years. All these factors contribute to the poor prognosis of the HCC patients. Sorafenib is the only currently approved systemic therapy for advanced HCC in the EU, only prolonging survival by an average of 3 months, the treatment often leads to drug resistance. Indeed, intra-tumor heterogeneity strongly constrains the therapeutic benefit of precision medicine and triggers drug-resistant sub-population of cells. Consequently, persistent treatment of drug-resistant tumor cells may accelerate tumor progression, suggesting that inappropriate and continual use of a compound on drug-resistant cancer cells is not recommended. Thus, there is an urgent unmet medical need to identify and to validate the therapeutic efficacy of new valuable molecules – i.e. targeting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Hydrogen Solutions for euroPean Airports & Regional Kinetics' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Hydrogen's importance globally is evident across multiple sectors like industry, energy, and transport, with the EU prioritizing renewable hydrogen production. Strategies outlined in the EU Hydrogen Strategy and REPowerEU plan aim to decarbonize the EU and reduce reliance on imported fossil fuels. The shift towards hydrogen requires comprehensive strategies, encompassing investment support, market creation, and global cooperation. HySPARK in Poland accelerates this transition by overcoming technological and non-technological barriers. With a production hub in Włocławek, it aims to produce over 3,000 tons of renewable hydrogen annually, serving various local applications. Six testbed applications will be tested for at least 2 years, gathering operational data to evaluate the techno-economic, societal, and environmental metrics. The testbeds will cover both the transport and the industry sectors and will consist of: (i) the upstream hydrogen production and (ii) the Hydrogen Refuelling stations infrastructure; (iii) 4 semi-trucks for freight road, (iv) 2 buses for the public road, (v) 8 tow tractors for the ground handling transport; (vi) Green Ammonia production. Each testbed application will be fully set up in terms of infrastructure, planning of the associated logistics and the synergetic management of all distributed assets, to demonstrate the practicality and efficiency of H2, also integrated within Warsaw Chopin Airport to contribute to EU's 2050 hydrogen-ready airports objective. Nevertheless, HySPARK will develop the user-friendly and intuitive Energy Planner utilized to refine and optimize the HySPARK supply chain, ensuring its seamless integration into the broader energy ecosystem. In connection with ongoing EU-funded projects (TH2ICINO and SH2AMROCK), HySPARK le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cognitive Robot for Automation of Logistic Processes' to be submitted under Seventh Framework.

assistant: **Abstract**

Globalization causes an increasing transport of goods. Nowadays, most goods are shipped in containers and are transferred onto trucks for further transport. The containers are unloaded manually since they are nearly always packed chaotically, the variety of transported goods is high, and time requirements are strict. Unloading of containers is a strenuous task as goods have a weight up to 70 kg that poses health risks, which include the effects of pesticides and poisonous gases as well as injuries through unexpectedly falling objects.  Human labor is hence a high cost factor combined with unhealthy working conditions, making automated solutions highly desirable. Existing systems for automated unloading are restricted to specific scenarios and still have drawbacks in their flexibility, adaptability and robustness. A robotic system suited for any unloading task of containers requires a high amount of cognitive capabilities. RobLog aims at developing appropriate methods and technologies meeting the requirements to automate logistics processes.The RobLog system has to be capable of 3D perception in a challenging scenario (high variability of objects, dynamic scene, deformable objects). The perceived environment has to be integrated into a 3D model in real-time. Grasping hypotheses, decisions and path-plans have to be generated and executed in an adaptive manner including obstacle avoidance and re-planning, if necessary. The actions must be grounded in a physical set-up capable of handling a large variety of potentially deformable items. Finally, there is the need to provide an interface suited for a human operator to provide high-level instructions to a multitude of systems operating at several unloading docks in parallel. All these advances are demonstrated within the proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mechanism of protein kinases in biomolecular condensates' in the context of a Horizon Europe call.

assistant: **Objectives**

Protein phosphorylation, mediated by kinases, plays a pivotal role in cellular regulation, with kinase dysregulation strongly associated with diseases like cancer, inflammation, and neurodegenerative disorders. Alzheimer's disease (AD) represents a significant global health challenge as the population ages at an accelerating pace. A key pathological feature of AD is the accumulation of hyperphosphorylated Tau, which disrupts normal neuronal function. Emerging evidence suggests that Tau undergoes liquid-liquid phase separation (LLPS), potentially linking AD and biomolecular condensation. Moreover, recent findings propose that LLPS intricately manages kinase signalling, creating condensed-phase structures (biomolecular condensates) that serve as recognizable sites for kinases. However, molecular mechanisms governing kinase behaviour within condensates are poorly understood. The central hypothesis of KinCond project is that the conformational landscape of protein kinases undergoes significant remodelling within biomolecular condensates, controlling substrate selectivity and specificity. This project focuses on the microtubule affinity-regulating kinase MARK2, a central player in the abnormal phosphorylation of Tau. KinCond is meticulously structured into three work packages: (1) investigating the specificity and reaction kinetics of MARK2 within Tau condensates, (2) deciphering the conformational landscape of MARK2 through advanced nuclear magnetic resonance methods and molecular dynamics simulations and (3) analyse the effect of biomolecular condensation on the conformational landscape of MARK2. The outcomes of KinCond are expected to provide crucial insights into the behaviour of protein kinases within biomolecular condensates, shedding much-needed light on the mechanism