RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Responsible Intelligent Systems' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

I propose to develop a formal framework for automating responsibility, liability and risk checking for intelligent systems. The computational checking mechanisms have models of an intelligent system, an environment and a normative system (e.g., a system of law) as inputs; the outputs are answers to decision problems concerning responsibilities, liabilities and risks. The goal is to answer three central questions, corresponding to three sub-projects of the proposal: (1) What are suitable formal logical representation formalisms for knowledge of agentive responsibility in action, interaction and joint action? (2) How can we formally reason about the evaluation of grades of responsibility and risks relative to normative systems? (3) How can we perform computational checks of responsibilities in complex intelligent systems interacting with human agents? To answer the first two questions, we will design logical specification languages for collective responsibilities and for probability-based graded responsibilities, relative to normative systems. To answer the third question, we will design suitable translations to related logical formalisms, for which optimized model checkers and theorem provers exist. Success of the project will hinge on combining insights from three disciplines: philosophy, legal theory and computer science.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'PHotonic REServoir COmputing' under Horizon 2020.

assistant: **Concept**

New computing paradigms are required to feed the next revolution in Information Technology. Machines need to be invented that can learn, but also handle vast amount of data. In order to achieve this goal and still reduce the energy footprint of Information and Communication Technology, fundamental hardware innovations must be done. A physical implementation natively supporting new computing methods is required. Most of the time, CMOS is used to emulate e.g. neuronal behavior, and is intrinsically limited in power efficiency and speed.Reservoir computing (RC) is one of the concepts that has proven its efficiency to perform tasks where traditional approaches fail. It is also one of the rare concepts of an efficient hardware realization of cognitive computing into a specific, silicon-based technology. Small RC systems have been demonstrated using optical fibers and bulk components. In 2014, optical RC networks based integrated photonic circuits were demonstrated. The PHRESCO project aims to bring photonic reservoir computing to the next level of maturity. A new RC chip will be co-designed, including innovative electronic and photonic component that will enable major breakthrough in the field. We will i) Scale optical RC systems up to 60 nodes ii) build an all-optical chip based on the unique electro-optical properties of new materials iii) Implement new learning algorithms to exploit the capabilities of the RC chip.The hardware integration of beyond state-of-the-art components with novel system and algorithm design will pave the way towards a new era of optical, cognitive systems capable of handling huge amount of data at ultra-low power consumption.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Weaving Technology based Automated Production Processes in the Composite Industry (We TAP IN)' (2014-2020).

assistant: **Concept**

The Weaving Technology based Automated Production Processes in the Composite Industry (We TAP IN) project aims at a commercial validation of high quality unidirectional glassfiber / polymer composite tape mass production technology and commercialization.  Industry developmentThe composite industry is a fast growing and widely expanding industry. The majority of all commercial composite product are based on thermosets. Thermosets can not be separated in the original fiber and matrix materials. Hence reuse or recycling is hardly possible. Within a few years the lack of recyclability imposes an undesired situation. ProblemMass production is required to server high volume commodity products and markets. Mass production require advanced automated production processes which requires thermoplastic tapes as semi-finished product. Current thermoplastic tapes are of limited quality, hampering the shift towards increased recyclability.Intended InnovationYears of involvement in the industry and the development of thermoplastic unidirectional tapes production processes resulted in an improved production method. The production method is based on an industry knowledge cross-over. The realization of a full scale mass production facility will be realized with an incumbent textile manufacturer, by means of a joint venture. BenefitOnce commercial available, the innovation contributes to a increased recyclability of new composite products. The use of high quality thermoplastic tapes will reduce weight in several products of high volume markets. The realized weight reduction of the products will result in a decrease of CO2 emission during the transportation and during the lifetime of products. EffectThe innovation bridges the gab between, low cost medium quality raw materials and advanced a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identifying strategies to reduce osteoporosis-driven bone loss through the development of microphysiological bone remodeling-on-chip tools' (ReModel-OP) under Horizon Europe.

assistant: **Objectives**

Osteoporosis is a common skeletal disorder characterized by imbalanced bone remodeling, where osteoclast activity is exacerbated leading to increased bone degradation and fracture risk. The socio-economic burden of this disease is elevated in the EU and is expected to further increase in coming years, highlighting the need of improved disease models and drug screening platforms in pre-clinical research. Organ-on-chip (OoC) technology has been demonstrating high potential to replace anima testing in drug screening and pathophysiological modeling, but current output measurements in OoC applications are still mostly limited to end-point assays or require large volume of sample. In addition, bone OoC models competent for exacerbated bone resorption, the main consequence of osteoporosis, are still lacking, indicating a need for improved and more representative models.To address this issue, in this project I aim to identify and validate potential strategies to reduce osteoporosis-driven bone loss, through the establishment of a bone-on-chip model with integrated sensors for online detection of bone degradation biomarkers. I will combine knowledge from disciplines ranging from microfabrication, tissue engineering, molecular biology, imaging and electrochemistry to fabricate osteoclast resorption biomarker sensors and integrate them in OoC models that faithfully replicate the bone microenvironment. My experience in osteoclast biology will be integrated with the extensive expertise of the Brigham and Women´s Hospital - Harvard Medical School in tissue engineering, microfabrication and materials science for the successful implementation of this proposal. These experiences will provide the optimal training environment not only to become a leader in organ-on-chip disease modelling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Investigating epigenetic silencing mechanisms within cancer' (BET-HUIDOBRO) under Seventh Framework.

assistant: **Objectives**

Epigenetic silencing is essential for modulating gene expression patterns in developing organisms and has very big impact on the genome integrity. Cancer, as well as many other diseases, has been linked to the changes in transcription of regulatory genes due to the aberrant epigenetic silencing.  Despite many epigenetic regulators, enzymes including histone deacetylases, methyltransferases, and DNA methyltransferases, were discovered, it is critical to bridge the gap in our understanding of the mechanisms contributing to chromatin structure modulation. We employed a phenotypic screening assay in mouse erythroid leukemia cells that harbour a silenced green fluorescent protein (GFP) reporter transgene in order to isolate new components of heterochromatic silencing and identify compounds that have potential to de-repress tumour suppressor genes in cancer cells. Strikingly among the compounds with strong anti-silencing properties we found inhibitors of bromo and extra-terminal domain (BET) proteins, which recently became massively popular as new generation chemotherapy anti-cancer drugs. Since so far BET proteins were mainly considered to act as transcriptional co-activators, we have set out to investigate the molecular mechanism of action of the BET inhibitors with respect to their anti-silencing properties. Our preliminary data suggests that inhibition of BET proteins results in loss of the DNA methylation, and specific histone modifications from heterochromatic regions. The aims of this proposal are: 1) To determine which BET proteins are important for heterochromatin maintenance; 2) To determine the mechanism of action of the key BET protein(s) in epigenetic silencing; 3) To analyse chromatin changes resulting from inhibiting of the key BET protein(s) in the selected ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Secure and protected interoperability' (SPIN).

assistant: **Concept**

The objective of the proposed project as a whole (phase 1-3) is to plan, develop, secure and bring to the global market an interoperability platform as a service that enables secure and protected information sharing and cooperation between sovereign partners, their products, systems, services and/or apps, with, up to military grade security. inclose will address security and integrity challenges in a hyper-connected world where organisations and individuals will want and need to interact and share information with each other in a way were their integrity and privacy are protected. In comparison to other platforms available on the market no data is stored on inclose. Information is not  possible to access for inclose i.e. only  recievers, who also fulfill the requirements set by the information owner, will be able to access data. The platform will be opened up for development of modules/services and will, due to its non-proprietary, have the capacity to leverage the global software industry and serve as a secure back-end to Internet-of-Things. inclose can be used by customers across all markets and segments facing difficulties in finding solutions that meet the requirements they have on security and integrity when working or sharing information with others.  inclose is based on over 10 years of concept development, demonstrations and prototyping in domains that have very high requirements on interoperability, security and integrity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'In vivo dynamics of nitrosylation and glutathionylation in Chlamydomonas reinhardtii and Saccharomyces cerevisiae' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Living cells have evolved a complex network of signaling pathways and adaptative responses which enable them to survive and adapt to diverse environmental challenges. Our increasing understanding of the molecular mechanism of cell signaling has revealed that reactive oxygen species (ROS) and reactive nitrogen species (RNS) act as signaling molecules to transfer extracellular or intracellular information and elicit specific responses. ROS/RNS mainly act through a set of reversible post-translational modifications (PTMs) of thiol residues on proteins among which nitrosylation and glutathionylation have emerged as key elements playing a major role in numerous fundamental cell processes and are implicated in a broad spectrum of human diseases. Emerging evidence suggests the existence of an intricate network of redox signaling pathways with a complex crosstalk between the different types of redox modifications. A specific pattern of redox-based protein modifications likely constitutes a molecular language that allows to trigger specific responses in response to the input signal. The aim of this project is to investigate, using an innovative proteomic technology, the temporal and qualitative dynamics of redox-based PTMs in vivo. The method will allow qualitative and time-resolved detection of nitrosylation and glutathionylation that will be analyzed simultaneously and specifically from each sample. This technology will be combined to bioinformatics modeling to unravel the role of redox-based PTMs associated with the responses to diverse physiological conditions or with different genetic backgrounds in two model unicellular eukaryotes: the yeast S. cerevisiae and the green alga C. reinhardtii. By providing a method to understand the dynamics of redox-based PTMs, this project i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Shaping the future – From spermatids to spermatozoa' (GettingInShape) targeting Horizon Europe.

assistant: **Abstract**

Sperm are highly specialised cells whose structure is optimised for a defined function. Although the distinctive sperm ultrastructure has been known for many years thanks to electron microscopy, an understanding of the molecular details of sperm specialisation is severely lagging. The gap in our molecular understanding relates to the difficulties in genetically manipulating sperm. Over the past five years, my lab has pioneered the use of cryo-electron tomography to study mature mammalian sperm at the molecular level. We developed workflows based on cryo-focused ion beam milling and sub-tomogram averaging that allowed us to provide the first in-cell structures of mammalian sperm flagella, revealing unique microtubule inner proteins. We further showed that the sperm centrioles and their surrounding matrix form a dynamic basal complex that facilitates a cascade of internal sliding, coupling tail beating with asymmetric head kinking. Although these findings contribute profoundly to the field, the resolution achieved in these studies (~20) precluded protein identification in most cases. Now I plan to develop a workflow based on single particle analysis, achieving near-atomic resolution, but without purification. I will apply this workflow, together with biochemical assays and cellular cryo-electron tomography, to humans and other species to resolve how germ cells get into shape and acquire motility. Specifically, the mechanisms underlining 1) nuclear shaping 2) centriole remodelling 3) mitochondrial sheath assembly 4) motor apparatus activation.Understanding how male germ cells get into shape is of clinical relevance, as sperm morphological defects are often observed in infertility. Moreover, the success rate of assisted reproduction technologies can be improved with better
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Transforming digital in-content advertising to deliver global scale' (LONGTAIL).

assistant: **Concept**

Today, digital advertising is dominated by big, US-driven companies like Google and Facebook, who provide the majority of the ads we see online. The old dominant concept has been to sell and show static banner ads in a fixed location, separated from Publisher digital content. The problem with this approach is that ads are placed where they are usually ignored and, being mostly poorly targeted, are not adding value to end users. The next generation concept in digital advertising will be in-content advertising, where advertising is turned into a service in order to enhance the end user experience. It means that advertisements are placed dynamically inside the actual content of the Publisher digital property and served in the right context for the right audience as identified by behavioral data. In-content advertising unites programmatic advertising technology with real-time bidding and performance based advertising. Kiosked launched its innovative in-content advertising platform in 2014, generating significant interest from publishers, advertisers and investors. Kiosked has grown over a 9 month period in a highly competitive marketplace to serve over 250 million people with more than 3 billion ads on a monthly basis. Growth continues, however, the current manual sales process has been identified as a limiting factor to growth; the next innovation is to enable a data driven automated online marketing and sales service. In this project, the Kiosked platform will be developed into a fully automated, end-to-end service, thereby allowing any digital publisher to onboard the service at any time. Data drives Programmatic advertising and effective advertising performance delivering enhanced end-user experience. This project enables Kiosked to efficiently connect Publishers’ audie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'BlueRemediomics: Harnessing the marine microbiome for novel sustainable biogenics and ecosystem services' in the context of a Horizon Europe call.

assistant: **Objectives**

Marine microbial communities perform critical life sustaining functions on Earth and represent a vast unexploited treasure trove of bioresources that have the potential to strengthen the European blue economy. To unlock this hidden potential, as well as responsibly conduct biodiscovery from marine microbes requires multiple developments. We need to amalgamate and apply advanced technologies to elucidate the composition, interactions and functional repertoire of the marine microbiome, while concomitantly ensuring sustainable and equitable exploitation, maintaining ocean health, and improving ocean literacy through an improved appreciation of ocean microbes.To address these needs, BlueRemediomics will: (1) develop and provide an integrated bioinformatics platform to explore the marine microbiome potential; (2) establish innovative culturomics and high-throughput screening platforms to experimentally exploit consortia of marine microbes; (3) apply the platforms to identify and develop natural products derived from marine microbes; (4) foster aquaculture and ecosystem services that embody the “do no significant harm” principle; (5) maximise equitable access to ocean microbiome resources and increase awareness of the marine microbiome to a diverse range of stakeholders; (6) Provide training, tools and resources to a variety of stakeholders. To achieve these objectives, BlueRemediomics interlinks an advanced “Discovery Platform” with “Applications”, so designed to facilitate cyclical and iterative crosstalk. By federating multiple, currently fragmented key data resources, the Discovery Platform will accelerate new product identification and development, reduce resource dependence, raise consumer benefits and address key societal issues. New modalities in access and benefit sh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantification of aerosol nucleation in the european boundary layer' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The purpose of QUEST is to quantify aerosol nucleation in the European boundary layer atmosphere. Continuous measurements and intensive field campaigns will be carried out in three different locations: Boreal (Finland), polluted Southern European (Italy), and coastal (Ireland). Prior measurements indicate that the nucleation mechanisms are somewhat different in each location. The objectives of the measurements are to fill in gaps that exist in the understanding of chemical and physical pathways leading to formation of new particles. Aircraft measurements will be performed in order to gain information of the vertical and horizontal extent of nucleating events. Parameterised representations of the nucleation mechanisms will be implemented in an European scale model in order to determine the source strength of new aerosol particles.