RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Analysing the role of history, chance and selection on the evolution of plasmid-mediated antibiotic resistance' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Antimicrobial resistance (AMR) in bacteria is one of the main challenges faced by modern medicine and understanding its evolution is urgently required. As any other evolved trait, three fundamental evolutionary forces guide the evolution of AMR: history, chance and selection. The specific role of each force determines whether, by what mechanism, and to what degree AMR evolves in a given population.  Horizontal gene transfer is the main route for acquisition of AMR in bacterial pathogens and plasmids play a key role in the spread of resistant determinants. Of critical clinical importance is plasmid-mediated  carbapenem-resistance in the Enterobacteriaceae family. The recurrent isolation of certain successful plasmid/bacterium associations in hospitals distributed worldwide is an example of how history and chance constrain the emergence of AMR. For example, pOXA-48 plasmid, encoding the OXA-48 carbapenemase, is frequently associated with the ST11 serotype of Klebsiella in hospitals around the world. Why is pOXA-48 restricted to a handful of clones if it can be mobilized to all K. pneumoniae serotypes? To answer this question, I am proposing a novel project that will analyze the impact of the three evolutionary forces in the evolution of plasmid-mediated AMR in clinical strains of K. pneumoniae. First, using experimental evolution and whole genome sequencing, I will quantitatively analyze the impact of each evolutionary force in AMR evolution. Also, I will study the adaptive mutational pathways leading to the compensation of plasmid-mediated costs. Then, I will use the novel high-throughput genetic screen CRISPRi, which allows silencing the expression of all chromosomal and plasmid genes one by one, to analyze the molecular basis determining the successful plasmid/bacteriu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'PMTrainingCourses' under Sixth Framework.

assistant: **Concept**

Powder Metallurgy (PM) is a fast growing key enabling technology with applications in many sectors eg automotive aerospace & construction . For historic reasons, PM is widely spread throughout the EU with production in at least 12 EU states and contain s a significant proportion of SMEs. This makes it very difficult on a national basis to achieve a critical mass of participants at high-level training. Therefore although European expertise in PM is currently of world standard, our advantage is being erod ed, mainly by Japan and the US who benefit from a good supply of high quality graduates and post-graduates into their industry sectors. It is against this background that the proposal for a coherent series of PMTrainingCourses is submitted. The European Powder Metallurgy Association (EPMA) is a pan-European industry organisation with members representing over 80% of the PM industry, that has successfully organised EU funded projects in the past. Based on direct industry feedback as evidenced by the ?Visio n 2020 - The European PM industry Roadmap? - the training of researchers at an early stage in their careers is seen as essential to the long-term competitive success of the European PM industry. The PMTrainingCourses programme will provide a coordinated and evolving platform, enabling up to 400 participants from across Europe, to benefit from a unique opportunity to receive teaching provided by some of the leading industrial and academic researchers in the PM world. The intensive & inclusive nature of the courses will foster links between students and tutors from a range of backgrounds and nationalities; and therefore will also significantly contribute to mobility of researchers and the integration of research capability on a European scale. In conclu sion the programme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dna biosensor for analytical investigation and labelling in food' (DNA-BAILIF) targeting Fifth Framework.

assistant: **Abstract**

The overall aim of this project is to develop methodologies and sensor arrays for the accurate sensitive and rapid identification of DNA associated with genetically modified (GM) plant material. Bearing in mind the importance of consumer confidence and the necessity to adequately test and label foods, it is necessary to develop a system, comprising methodologies and state of the art technologies, for high throughput screening of plant materials. It is envisaged that such an approach will ultimately make possible effective monitoring and policing of the distribution and labelling of GM and non-GM foods in the World markets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New biodegradable anal plug to manage Faecal Incontinence' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

My-qup is developing an anal plug, qup, for the management of faecal incontinence (FI) that will reduce the environmental impact that other solutions like pads, diapers and non degradable anal plugs produce. It will be sold to autonomous patients to help them recover their Quality of Life (QoL). FI affects most parts of the patient's life, including laboral, social and sex life. qup users will be able to regain control of their defecation, providing enough safety to return to their previous lifestyle. My-qup Medical considers the whole user experience with a holistic design that tackles all the sides of conservative treatment (non-surgical treatment) and management of FI. The main achievements of the project are the innovation in the material and the design. It will significantly reduce waste and use of resources. The material has been developed to comply with the European Guides of flushability. The next challenges for the product are to prove the usability and efficacy with the users, and to find manufacturers to start a small production to conduct a clinical trial.  The estimated global market of FI is USD 2,000 MM with an estimated prevalence of a 10% of adult population with a growing incidence due to an aging population. There are 93 million potential users in the developed world that will be, in most cases, chronic patients. The potential client of My-qup Medical will be the user of qup: autonomous patients that, if it wasn’t for this condition, could have a normal life. As FI is a global problem, after reaching the developed world it will be necessary to study the entry in developing countries.SME Instrument Phase I would serve to assess: the feasibility of licensing vs. reaching the market, the usability of the product (including efficacy, comfort, satisfaction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Synthesis of conformationally restricted b-turn mimetics for incorporation into peptide hormones used as drugs' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content The project describes an innovative and general approach to the synthesis of conformationally restricted mimetics of b-turns in biologically active peptides and proteins. The approach will be applied to the peptides hormones vasopressin, oxytocin and LHRH which are used as drugs. The pharmacodynamic and pharmacokinetic properties of the resulting hormone analogues will be evaluated in collaboration with FERRING Pharmaceuticals in Malmoe Sweden. It is expected that the analogues will display increased stability on oral administration, resulting in prolonged duration, and that information on the biologically active conformation of the hormones will be obtained. Training content (objective, benefit and expected impact) The project will widen my knowledge in synthetic organic chemistry, especially in synthesis of peptides, and also give me insight into very modern techniques like combinatorial chemistry, molecular modelling and conformational studies of peptides and peptidomimetics. All these techniques are of great interest and relevance for my planned career in chemical industry. In Addition, I will learn a new language (Swedish) and will widen my knowledge in English by permanent training. Links with industry / industrial relevance (22) The pharmacological properties of the synthetic peptidomimetics to be prepared in this project will be evaluated in collabo- ration with FERRING Pharmaceuticals in Malmoe Sweden. FERRING's main products are analogues of the hormones vasopressin and oxytocin which are used in treatment of diabetis insipidus and premature labour, respectively. In addition, the group is collaborating with PHARMACIA Immunology/Oncology in Lund in combinatorial chemistry and with scientists at ASTRA DRACO in Lund concerning synt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Communities of marine microrganisms for oil degradation'.

assistant: **Innovation**

Marine ecosystems and the fossil fuel petroleum oil are major natural resources whose use necessitates sustainable practices. Oil is toxic and its mining, transport and use results in much pollution, particularly of marine ecosystems. Some marine microorganisms degrade oil and play a crucial role in reducing its pollution impact thereby constituting a major factor in the sustainability equation, but we know almost nothing about them, and are not able to rationally influence their beneficial activity. In order to fill this critical knowledge gap, and elucidate the identity and functional roles of the most important degraders, the biogeography and phylogenetic and functional diversity of oil-degrading bacteria, the structure and function of oil-based microbial communities in which they act, population dynamics and degradation rates of such communities in response to oil pollution, will be studied and the potential for rational intervention to enhance their beneficial activities assessed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A Global History of Technology, 1850-2000' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

What role did technology play in the age of colonization and globalization? The proposed project, A Global History of Technology, 1850-2000 (GLOBAL-HOT), explores this vital question. Traditional histories written about this period usually trace the wide circulation of mainstream technologies—from railways and telegraphs to container ships and mobile phones. The standard narrative claims these technologies supported colonialism and later triggered globalization—the growing uniformity and homogenization of lifestyles and practices worldwide. GLOBAL-HOT challenges this linear view of technology and globalization.Another feature of traditional histories is their focus on the Global North—Europe and North America. A Global History of Technology counterbalances this focus by expanding the research to include the long-neglected Global South: Asia, Africa, and Latin America. By analyzing these continents’ artifacts, infrastructures, and practices—whether indigenous, imported, or hybrid—we will revise standard accounts of users in the Global South as passive recipients of artifacts and consumer goods.The GLOBAL-HOT project team seeks to support three key hypotheses:1. Technologies circulated between the Global North and the Global South. Artifacts and material systems did not flow in one direction only: from North to South, e.g., from Europe to the rest of the world.2. The development and use of technologies took on a variety of forms—not a single, “globalized” form—in various parts of the world.3. The local appropriation of globally circulating artifacts and technical solutions was primarily a highly specific and often contested process.The overarching goal of the project is to increase our understanding of the relationship between the development and use of technologies—wheth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Flexible fabrication of lightweight aluminium transport structures'.

assistant: **Concept**

The Flexi-Fab project aims to develop a flexible FSW welding system capable of automatically fabricating complex structures, in a variety of joint configurations, from a range of aluminium alloy grades and thicknesses used in the transport sector.Flexi-Fab will deliver significant benefits to the metal working and fabrication industry by providing a cost-effective method of fabricating aluminium structures that will enable:• European fabricators, metal-workers and welding companies to effectively compete in the growing use of aluminium alloys for use in the light-weight transport sector.• Capitalising on the increasing pressure to replace traditional iron and steel material with aluminium alloys to reduce weight and thus fuel consumption of vehicles, trains, ships/boats and aeroplanes.• A reduction in the costs associated with the fabrication of aluminium structures, especially focussed on components used within the transport sectors.• The development of new and protectable IP in the area of automated aluminium welding systems - to protect European manufacturing industries competitiveness and enhance the move into the ‘knowledge-based’ manufacturing sector.EWF - The European Federation for Welding, Joining and Cutting (EWF), which represents the European SME metalworking community (via membership of 32 national European associations), has initiated this project to facilitate the adoption of automation within the aluminium joining industry.  The successful implementation of the Flexi-Fab project will enable their members to optimise labour efficiency of highly skilled manual welders, safeguard their health (and working length of their careers), increase productivity of European companies and reduce costs so that they can more effectively compete with global players, part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A Hungarian Night for Researchers 2011- Hungary-EU Research Careers' (HEURECA) under Seventh Framework.

assistant: **Objectives**

We will focus on enhancing researchers’ public recognition. Researchers, presented as persons that everyday people can relate to, can draw attention to science; and can make science seen as a casual but interesting adventure. Better understanding science can also lead to improving researchers’ recognition. Thus, the main message of the event will emphasize the human, accessible yet important figure of the researcher working for the benefit of the society.RN is an event that attracts a growing number of visitors and cooperating bodies each year. This year we plan a brand new exciting project that retains some indispensable elements from the previous events. We will actively involve young people because we believe that future scientific and technological development lies in their hands. The main driving forces and themes of our programmes are connection and interaction. Connection and interaction between different scientific fields, Science and Arts, scientists, science and children/pupils/students, researchers and laymen, science and companies, research and everyday life, research and hobby; between partner universities, research institutes and industrial companies. Connection and interaction with media is also indispensable in order to enhance researchers’ public recognition and to raise awareness of the importance of science and research by putting in the spotlight scientific achievements and researchers. Our choice of key theme is reinforced and further coloured by the fact that 2011 is the International Year of Chemistry – so we will closely examine chemical bonds, unions and interactions as well.Again, we will involve the public in a wide range of exciting scientific activities that are interconnected and are implemented through intense cooperation between the conso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developing and implementing innovative Patient-Centred Care Pathways for cancer patients' (MyPath) targeting Horizon Europe.

assistant: **Abstract**

In the EU, 2.7M people were diagnosed with and 1.3M died of cancer in 2020. Over 12M people have survived cancer, thanks to advances in early detection and new therapies. With higher cure rates and more patients living longer with cancer, access to patient-centred care consisting of optimal supportive, palliative, survivorship and end-of-life care becomes increasingly important. However, cancer care still has silos, and to this day, there is no technical support available that is suitable for different cultures, settings and environments.Several randomised controlled trials have provided evidence that the integration of patient-centred care in standard oncology care results in better patient and caregiver outcomes. As yet, these findings have not translated into clinical routine.In this project, we will develop technology-enhanced and evidence-based patient-centred care pathways, called MyPath, to be merged with tumour-centred treatments across supportive, palliative, survivorship and end-of-life care. MyPath integrates patient-reported outcomes of the OUS Eir software, to be further advanced with contributions of renowned European oncologists, ethicists, psychologists and sociologists. It will be configurated on the eHealth platform of our SME partner DNV Imatis. Its effectiveness and sustainability will be assessed in an implementation science study in 9 clinical centres across Europe. With the support of leading cancer care professional associations ESMO and EAPC, we are committed to delivering the right care to the right person at the right time by the right persons.We hypothesise that MyPath can significantly improve the quality of and access to treatment and care, reduce variations in clinical practice, and optimise resources in family, community, and hospital car
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Funding Frictions after the Global Financial Crisis' (FuFri) under Horizon Europe.

assistant: **Objectives**

Funding frictions are tensions in financial markets that can preclude institutions from borrowing money or rolling over debt. In extreme situations, such as the 2007-2009 global financial crisis (GFC) or the market turmoil in March 2020 during the Covid-19 pandemic, funding frictions can lead to the default of otherwise healthy institutions and destabilize the entire financial system. While earlier research (pre-GFC) tends to disregard funding frictions, the enormous risk associated with these market tensions highlights that a deeper understanding of funding frictions is crucial - it can guide policy makers to determine their optimal responses to future crises and help institutions to reduce their funding risk.In this project, I will investigate how funding frictions affect financing conditions for countries, banks, pension plans, and life insurance companies. While funding frictions can, in the most extreme cases, lead to the bankruptcy of otherwise healthy entities, they usually first manifest through elevated costs for external financing, shorter debt maturities, or a lack of access to certain credit markets. Focusing on these aspects, I will investigate the following question: How did the market developments since the GFC affect funding frictions for countries, banks, pension funds, and insurance companies? More specifically, I examine four post-crisis changes in financial markets - (i) ballooning deficits in most developed economies, (ii) tighter regulation of Money Market Mutual funds, (iii) pension risk transfers with firms transferring their defined benefit (DB) pension plans to life insurance companies, and (iv) tighter bank regulation (as implemented in the Basel III capital accords) - and study their impact on funding costs and access to credit markets. The r