RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Pathogen Phylodynamics: Unifying Evolution, Infection and Immunity'.

assistant: **Innovation**

Genetic sequences represent a rich source of information about evolutionary and ecological processes in natural populations. However the development of methods to recover this information is being outpaced by the explosion in sequence data, especially since the introduction of ‘next-generation’ sequencing. This problem is particularly acute for the inter-disciplinary field of pathogen phylodynamics. The rapid evolution of many pathogens means their ecological and evolutionary dynamics occur on the same timescale and therefore new analytical methods are required to study this joint behaviour. Further, the small genome sizes and medical importance of many viruses mean that hundreds of thousands of homologous sequences are already available, and sample sizes will continue to grow. The main goal of this proposal is to develop and apply multiple new frameworks of evolutionary analysis, to unlock the full potential of current data and to exploit new types of sequence data for which no rigorous analytical methods currently exist. Across four related themes I will use these novel methods to answer major unsolved questions about the evolutionary dynamics of viruses and their hosts: (i) How can we measure adaptation in data sets comprising many thousands of genomes? (ii) Can we reveal the adaptation of viral lineages to the genetic variation in immunity present in host populations? (iii) How can we combine mathematical ecological models with viral genomics to better predict the outcome of chronic HIV and hepatitis C virus infection, or the success of anti-viral drug therapy? (iv) Can we apply methods from ecology and evolution to analyse new data on immune receptor diversity, and use them to better understand the dynamics of leukaemia and viral infection? The suite of analytical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Benchmarking Integrated Care for better Management of Chronic and Age-related Conditions in Europe' (2007-2013) under Seventh Framework.

assistant: **Objectives**

INTEGRATE aims at gaining valuable insights into integrated care, starting from the premise that it offers benefits for patients and for Europe’s health and social security systems, which are facing the challenges of an ageing population and increased chronic conditions. For these benefits to be realised, there is still much to be learnt in terms of process design, service delivery, skills mix, patients’ involvement, funding flows, regulatory conditions, and enabling information technologies to create connectivity, alignment and collaboration within and between the cure and care sectors.INTEGRATE will look into best practices of integrated care that have a proven impact in terms of positive patient care experiences; care outcomes and cost-effectiveness. The key aim is to define what constitutes good quality integrated care provision. By studying real case studies considered to be examples of interesting integrated approaches to medical care and a defined set of horizontal issues across different European health systems, we will identify generic success factors of care integration, taking into account context dependency. The results will be contrasted with international evidence and feed into operational and policy recommendations.INTEGRATE brings together a multi-disciplinary team with extensive knowledge of the challenges involved in promoting integrated care, drawing on financial, regulatory, human resources, technological, and managerial perspectives, covering very different European settings, including a new Member State, building on existing collaborative relationships. To ensure scientific coherence and maximise the chances of achieving effective policy change, INTEGRATE builds on the strong, existing network of IFIC (International Foundation of Integrated Care).I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New all-optical systems and methods for precise magnetic and electromagnetic field measurements (NEW MAGNETOMETER)' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

A number of different methods for DC and AC magnetic field (MF) measurements are used. The most sensitive magnetometers are based on super conducting quantum interference devices (SQUIDs). A major drawback of these instruments is their extremely low operating temperature. Optical methods are also used, and recently the possibility of applying Coherent Population Trapping (CPT) effect for weak MF measurement was emphasized. The aim of this project is to carry out theoretical and experimental research to explore the potential of the CPT effect for precise MF and electromagnetic field (EMF) measurements. CPT based magnetometers would operate at room temperature and it is estimated that they would have sensitivity comparable to the SQUIDs' (and better spatial resolution). Prototypes of small portable CPT devices for general MF measurements and for applications in medicine and industry should demonstrate the possibilities of this new technique.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Investigating the transcriptional regulation of auxin biosynthesis in Arabidopsis embryo'.

assistant: **Concept**

Survival of flowering plants is determined by the proper production of seed, whose shape and size are defined by the development of an embryo. Such mature embryo mimics the body pattern of the new plant that will develop after germination. Auxin is a key regulator of various aspects of plant development, including embryo morphogenesis. Cellular auxin gradients, maintained by auxin production along with signalling and transport, are essential for proper embryo development. The embryonic local auxin biosynthesis appears spatiotemporally controlled, necessitating the presence of regulatory networks. Also, it became evident that auxin plays a critical role as an integrator of environmental cues, notably high temperatures, known to impair seed production. Thus, I aim at deciphering the molecular and genetic mechanisms behind the spatiotemporal regulation of auxin biosynthetic genes during embryo development, and how this regulatory network is impacted by heat stress. In the proposed work, I will functionally dissect the contribution of AGL transcription factors, identified in a yeast one-hybrid screen as binding to auxin biosynthetic promoters, to the direct regulation of auxin biosynthetic pathways using multidisciplinary approaches such as genetics, metabolomics, and molecular biology. Further, I will investigate whether high temperatures impact this regulation, notably at epigenetic levels. Overall, the proposed work would serve as an excellent foundation to dissect the mechanisms responsible for local auxin biosynthesis during embryo development, which would pave the way to devise strategies for mitigating the effects of climate warming on seed and plant morphogenesis.


**Keywords:** Auxin biosynthesis, Transcriptional regulation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The first heart failure therapy management point-of-care device with multiplex and multimodal sensor' (CardioCap) under Horizon Europe.

assistant: **Objectives**

CardioCap is the first ever multiplex and multimodal point-of-care (POC) device used for heart failure (HF) therapy management. With just a prick on the patients finger, and a drop of blood, healthcare professionals can deduce the severity of the HF patients conditions through simultaneous detection of 4 blood biomarkers, namely potassium, sodium, creatinine and NT-proBNP. With the comprehensive data generated by the 4 biomarkers, they can make prompt and informed decisions on the appropriate treatment. By optimising the drug dosage or exploring other treatment options, they can prevent patients entering acute decompensation events or adverse side effects, such as kidney failure.CardioCap is a handheld POC device that works with a drop of blood from the prick of a finger, and is as user-friendly as a glucometer. It performs at the same standard as the gold benchmarks (i.e. The Stratus CS by Siemens, COBAS CARDIAC NTproBNP+ by Roche and standard laboratory testing), but is used after patients are discharged from hospitals. With CardioCap, continuum care for HF patients is made available after hospital discharge, at the patient's home, community care centres, neighbourhood clinics and pharmacies. Re-hospitalisation rate and mortality rate is expected to be reduced by at least 30%. Furthermore, it helps to free up the hospital capacity for other emergency cases that could not be prevented. This mission is aligned with the health inequality gap in the EU, with the World Economic Forum (WEF) stating that ill health accounts for 20% of total healthcare cost. In closing the health inequality gap, the WEF urged for health initiatives such as POC that enable people to receive the health services they need.


**Keywords:** heart failure, medical device
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Identification and functional analyzis of the subnuclear protein complex of phytochrome B photoreceptor in Arabidopsis thaliana'.

assistant: **Innovation**

Light is one of the most important environmental signals regulating a wide range of physiological and developmental processes in plants, from seed germination to flowering. To perceive changes in the light, plants evolved photoreceptors specialized in absorbing light of different wavelengths. Phytochromes are the red/far-red light-absorbing photoreceptors of plants. Phytochromes (phyA-phyE) control responses throughout the plant life like seed germination, seedling de-etiolation, shade avoidance and transition of flowering. PhyA and phyB are the most prominent phytochromes to mediate photo-morphogenesis under normal conditions and phyB has major role to control light responses in mature, de-etiolated plants. To date, little is known about phyB mediated signalling cascade, however, clear evidences show that a specific set of genes are regulated by phyB-signalling. Light induces nuclear import of phy (A-E) and formation of phytochrome-containing nuclear protein complexes termed speckles or nuclear bodies (NBs). Although the precise function of NB formation is unknown, it is tempting to speculate that NBs are closely associated with phyB signalling. The project aims to unravel the link between phyB-NB formation and phyB signalling. I would like to purify and determine the components of phyB containing subnuclear complexes from Arabidopsis thaliana using tandem affinity purification (TAP) method and mass spectrometry. After determination of NB complexes, the biological function of identified protein components would be examined on multi-level from plant physiology to molecular biology. As we expect, we can uncover new factors and downstream steps of phyB mediated red-light signalling pathway after NB formation. Determination of phyB-signalling complex could also help us for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modelling sedimentation and vegetation patterns in tidal marshes' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The objective of the proposal is to develop and evaluate a multidisciplinary model that enables to predict changes in surface elevation and plant species distribution in tidal marshes. The model should be 2-dimensional, simulating spatial variations within tidal marshes, and suitable for long-term (10-100years) predictions in response to changing sea level and sediment supply. In a first phase, an existing2-dimensional hydrodynamic and sediment transport model (Delft3D) will be applied to simulate spatial sedimentation patterns during individual tidal cycles. The model will be evaluated using extensive field data sets from a specific marsh in the SW Netherlands. In a second phase, these short-term simulations will be up-scaled to a long-term simulation model, using the approach of Tem merman teal. (2003a). The long-term model will be evaluated against old topographic maps of the tidal marshes in the SW Netherlands. In a third phase, a statistical vegetation model will be developed, based on existing monitoring data from the SW Netherlands, that describes the spatial distribution of tidal marsh species as a function of salinity and elevation gradients. The vegetation model will be spatially implemented in a geographical information system and evaluated against existing vegetation maps. Finally, the sedimentation and vegetation model will be integrated to account for feedback mechanisms between changes in elevation and vegetation. After model evaluation, using historical vegetation maps, simulations will be run to assess the impact of future sea-level rise on tidal marsh dynamics. Given the world-wide and EU importance that is attached to the impacts of global change and sea-level rise, and given the opportunity to study this in collaboration with leading European institu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Life-time prediction of high-performance concrete with respect to durability' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

In the manufacturing of High Performance Concrete (HPC) unpredictable economic and technical risk arise. In the HPC industrial by-products and admixtures are combined with an ultra strength concrete. Such an expansion of the limits of a structural material like concrete makes life-time prediction rather impossible. With regard to the lacking of life-time data of HPC, this project has designed a research program, studying systematically the durability of different concrete design concepts, exposed to various climatic conditions in Europe. The correlation between the behavior in the laboratory as well as in the field and the analysis of deterioration mechanisms enables to develop degradation models, which lead to reliable service-life prediction. Concrete becomes also more environmental compatible, cost efficient and safer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Male Paediatric Fertility Restoration using Testis Organoids' (Restore-Fertility) targeting Horizon Europe.

assistant: **Abstract**

Chemotherapy treatments for cancer and haematological disorders can lead to male infertility. While adult males can freeze a sperm biopsy prior to chemotherapy, pre-pubertal children cannot do so, as they do not yet produce sperm. Reaching 88% survival rate for paediatric cancers nowadays, many of these kids will survive to adulthood but remain infertile. There are currently no clinical fertilityrestoration options available for these kids. Many of them are advised to undergo a testis biopsy procedure for fertility preservation prior to chemotherapy, with the hope that techniques will be developed to allow the use of these samples for future sperm production.Within the ERC StG, we aimed to develop an in vitro system that can closely model the testis. As such, we have recently published the development of testis organoids from both embryonic and prepubertal mouse testis. These organoids can be cultured in vitro for 9 weeks, while preserving all cell types normally present in the testis. These organoids highly recapitulate the in vivo state by creatingstructures, as well as presenting expression profiles, of in vivo testis. We developed defined media composition for in vitro maturation. Finally, we show indications that meiosis is initiated in vitro within the organoids.In this ERC PoC, building on our development in the mouse, we will generate human testis organoids derived from pre-pubertal testis biopsies that were obtained prior to chemotherapy treatment. We will assess the ability of these testicular cells to create human testis organoids, and analyse the structure, transcriptome, as well as ability to initiate, and potentially complete, meiosis. Within Restore-Fertility, we aim to achieve significant progress with the technology development in human samples, and pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Low-toxicity azine-based cationic lipids for gene transfection' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The project is aimed at the biochemical and biological investigation of a new class of molecules with azinic core (triazine, pyrimidine, etc.), featuring (1) detergent properties, for the transfer of oligonucleotidic genetic material (DNA, RNA, and mimics like PNA, etc.) into the cell nucleus (transfection), and (2) low cytotoxicity. The other principal structural features are: a thiol moiety for the formation of disulfide bridges in aqueous DNA and RNA, solutions; a protonable amine function not linked to the azinic core; a lipophilic chain to provide lipidic characteristics.These molecules could be used as transfection reagents for biological, biochemical and biomedicinal laboratories, and in perspective as drugs for gene therapy.The work will be carried o ut within the frame of a collaboration between the host Institution (CNR-ICRM) and Politecnico di Milano, which in turn hosts the CNR-ICRM section, in a new biology laboratory (Bio Cell) recently set up for the study of biological applications of engineeri ng and chemistry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'IMPROVED ENERGY EXTRACTION FROM FRACTURED GEOTHERMAL RESERVOIR' (1994-1998) under Fourth Framework.

assistant: **Objectives**

To demonstrate that water injected into a naturally fractured geothermal reservoir through production wells in such a way that the overall extraction of the heat energy from the reservoir will increase.To demonstrate the improvement in mining efficiency achieved by applying the reinjection method in geothermal exploitation. To show a technical and economical feasibility of using reinjection as a production method in low temperature geothermal utilization in Iceland.Reinjection is continuing at a rate of 8-20 l/s. Comprehensive monitoring is on-going. Preliminary results are positive.Laugaland is the largest of five low-temperature geothermal fields utilized for district-heating in the town of Akureyri in Central N-Iceland. It is located 13 km south of Akureyri and has been utilized since 1977. Because of the low overall permeability of the Laugaland system, the relatively modest production has lead to a great pressure drawdown and limited productivity. This drawdown continues to increase with time if constant rate production is maintained. Because of the nature of the Laugaland system, it is ideal for testing how injection can improve the productivity of low permeability geothermal systems in fractured volcanic rock. A two week injection test at relatively low injection rate, carried out in 1991, showed that the injected water diffused into a very large volume, which reflects conditions favorable for injection. A long term test with high injection rate is, however, needed to determine the feasibility of the project.Return water from the district heating system in Akureyri is the most suitable fluid for the injection, because it has the same chemical composition as the reservoir fluid. Therefore, a 13 km pipeline from the market in Akureyri to the geothermal field at Lau