RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The new science and technology of edible robots and robotic food for humans and animals' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Ordering your pizza and having it delivered in a few minutes by a drone? That could soon be routine. But what about having the drone itself for dessert, instead of sending it back? That would be entirely new technological territory with applications far beyond take-away meals. By combining food science and robotic science in a radically new way, the ROBOFOOD project will for the first time create robots that can be eaten and foods that behave like robots. Such edible robots could deliver lifesavingnutrition to humans in emergency situation; they could supply vaccines and supplements to endangered animalspecies; robotic food with edible actuators and electronics, on the other hand, could tell us when it is well preserved and safe to eat; it could protect itself from excessive heat or humidity during storage; it could facilitate swallowing for neurologic patients, and interact with humans and animals in totally new ways, to address dietary goals or influence eating habits. These goals require an interdisciplinary investigation into the principles of robotics and food science, which have very different and contrasting properties. Traditional robots are inorganic systems that perceive the environment and perform actions. Food instead is mostly organic material that can be digested and metabolized to support life. We will use soft robotic principles and advanced food processing methods to establish a common ground, and pave the way towards a new design space for edible robots and robotic food. We will validate it with proof-of-concept technologies for animal preservation, human rescue, human nutrition. The project is profoundly interdisciplinary, merging two fields that have hardly ever interacted before and pushing them well beyond the state of the art; its ambitious scienc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Adaptive multi-tier intelligent data manager for Exascale' to be submitted under Horizon 2020.

assistant: **Abstract**

The growing need to process extremely large data sets is one of the main drivers for building exascale HPC systems today. However, the flat storage hierarchies found in classic HPC architectures no longer satisfy the performance requirements of data-processing applications. Uncoordinated file access in combination with limited bandwidth make the centralised back-end parallel file system a serious bottleneck. At the same time, emerging multi-tier storage hierarchies come with the potential to remove this barrier. But maximising performance still requires careful control to avoid congestion and balance computational with storage performance. Unfortunately, appropriate interfaces and policies for managing such an enhanced I/O stack are still lacking.The main objective of the ADMIRE project is to establish this control by creating an active I/O stack that dynamically adjusts computation and storage requirements through intelligent global coordination, malleability of computation and I/O, and the scheduling of storage resources along all levels of the storage hierarchy. To achieve this, we will develop a software-defined framework based on the principles of scalable monitoring and control, separated control and data paths, and the orchestration of key system components and applications through embedded control points. Our software-only solution will allow the throughput of HPC systems and the performance of individual applications to be substantially increased – and consequently energy consumption to be decreased – by taking advantage of fast and power-efficient node-local storage tiers using novel, European ad-hoc storage systems and in-transit/in-situ processing facilities. Furthermore, our enhanced I/O stack will offer quality-of-service (QoS) and resilience.  An integrat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Peptide-based Robust and Innovative Molecular Condensate Engineering for Antibody-Drug Conjugates' (PRIME-ADC).

assistant: **Innovation**

Antibody drug conjugates are among the most promising targeted cancer therapies, combining the specificity of monoclonal antibodies with the potency of cytotoxic drugs. Yet, more than 80% of ADC candidates fail to progress beyond early clinical stages. A key reason lies in current conjugation chemistries: lysine- and cysteine-based methods yield heterogeneous products with unstable linkages, poor pharmacokinetics, and high manufacturing inefficiencies, wasting up to 50% of material. Copper-catalyzed click chemistry (CuAAC) offers the promise of precise, site-specific conjugation, but copper toxicity has prevented its industrial use, while copper-free alternatives require costly antibody engineering and compromise reaction kinetics.PRIME-ADC introduces a breakthrough solution: peptide-based biomolecular condensates engineered as programmable microreactors for CuAAC conjugation. These condensates selectively recruit antibodies and hydrophobic drugs into their dense phase, enabling efficient, stoichiometric coupling with controlled drug-to-antibody ratios. At the same time, copper ions remain in the dilute phase and are removed via simple centrifugation, eliminating toxicity risks and simplifying downstream purification. This one-pot, aqueous, and recyclable system yields homogeneous, stable ADCs with predictable pharmacokinetics, while reducing solvent use, energy demand, and purification costs.The proof of concept will validate PRIME-ADC with cetuximab and clinically relevant payloads, benchmark performance against standard chemistries, and demonstrate regulatory-compliant copper clearance. In parallel, business feasibility will be established through market validation, competitive benchmarking, and the design of a spin-out company. If successful, PRIME-ADC will unlock t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'AP-1 (Fos/Jun) Functions in Physiology and Disease' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Our research interests lie in breaking new ground in studying mechanism-based functions of AP-1 (Fos/Jun) in vivo with the aim of obtaining a more global perspective on AP-1 in human physiology and disease/cancer. The unresolved issues regarding the AP-1 subunit composition will be tackled biochemically and genetically in various cell types including bone, liver and skin, the primary organs affected by altered AP-1 activity. I plan to utilize the knowledge gained on AP-1 functions in the mouse and transfer it to human disease. The opportunities here lie in exploiting the knowledge of AP-1 target genes and utilizing this information to interfere with pathways involved in normal physiology and disease/cancer. The past investigations revealed that the functions of AP-1 are an essential node at the crossroads between life and death in different cellular systems. I plan to further exploit our findings and concentrate on utilising better mouse models to define these connections. The emphasis will be on identifying molecular signatures and potential treatments in models for cancer, inflammatory and fibrotic diseases. Exploring genetically modified stem cell-based therapies in murine and human cells is an ongoing challenge I would like to meet in the forthcoming years at the CNIO. In addition, the mouse models will be used for mechanism-driven therapeutic strategies and these studies will be undertaken in collaboration with the Experimental Therapeutics Division and the service units such as the tumor bank.  The project proposal is divided into 6 Goals (see also Figure 1): Some are a logical continuation based on previous work with completely new aspects (Goal 1-2), some focussing on in depth molecular analyses of disease models with innovative and unconventional concepts, such
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Forming of aluminum alloys at elevated temperature' (FALET-HL-CEMUC).

assistant: **Innovation**

This proposal of Intra-European fellowships deals with the joint proposal between Dr H. LAURENT of “Laboratoire de Génie Mécanique et Matériaux” of “Université de Bretagne-Sud” (UBS-LG2M) in France and Professor L.P Menezes of the “Centro de Engenharia Mecanica"" of ""Faculdade de Ciências e tecnologia da Universidade de Coimbrada” (FCTUC-CEMUC) in Portugal. The aim of this project is to reinforce research between our two laboratories in the domain of sheet metal forming and to give opportunities to Dr. H. LAURENT to develop his research training project. The objective is to put in common the potentialities of laboratories in the knowledge of the formability of aluminium alloys at elevated temperatures.  The Unit research CEMUC has been part of a Mundial project of “Digital Die Design – 3DS – IMS” and has achieved an European dimension notoriety beside research laboratories and manufacturers. The project of researcher Dr LAURENT, during the years 2008-2009 in the University of Coimbra, is to improve his knowledge in the experimental and numerical studies in metal forming. This advanced training will provide the means to significantly advances in his career and give him the possibility to obtain the title of Professor in France. This collaboration leads to publish common works in several journals and international conferences.  The aim of this study is to investigate the springback of aluminium alloy sheet during warm deep-drawing process. We shall compare several phenomenological models of elastoplasticity and model of elasto-visco-hysteresis for the prediction of springback for the deep drawing of aluminium alloy. Experimental springback ring tests (Demeri’s test) will be performed to measure material deformation and displacement during cup forming, ring trimming and s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Robust and Self-organizing Networks'.

assistant: **Concept**

Networks in transport, logistics, and telecommunication are pivotal for European and similar modern societies. The networks are complex and of very large scale. They must be operated both efficiently and reliable. At the intersection of mathematics, computer science, economics and engineering a huge body of linear and discrete network optimization methods has been developed. Methods for robust optimization form a younger field, topically attracting a lot of attention both mathematically and from practice. Recently, the concept of Recoverable Robustness, which we developed in an FET project, has significantly enlarged the possibilities to combine robustness and network optimization. The concept is well understood and proved useful in practice when the recovery is a linear program. The case when the recovery is an integer linear program has far broader modeling power. This case is almost untreated. In many applications the networks are not controlled by a central optimizing authority. They are operated by selfish players. A market mechanism must guarantee that the players in pursuit of their own benefit achieve global efficiency and reliability. Mechanism design is a thriving field with high international and interdisciplinary visibility. While many mechanisms for optimization problems are known, mechanisms that instill robust solutions are untreated. Given a market mechanism to instill robustness in a network controlled by selfish players at minimum loss in efficiency, a different application stands to reason: the networks created by credit obligations. To design regulations yielding robust credit networks it seems reasonable to complement classical, stochastic techniques with robust network optimization and algorithmic game theory. Such a new approach will have huge imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Systems Analysis Environment for the Integration of Renewable Energy with De-central Water and Power Production in Mediterranean Partner Countries' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

In MPC a large deficit of well equipped and reliably operated de-central Integrated Water and Power Points (IWPP) for villages and in rural areas is seen. Water and power authorities supported by regional R&TD institutions in MPC could reduce such de ficits if they developed their own capacity for flexible, innovative, fast and cost-effective assessment of technically and socio-economically appropriate solutions. Based on the experience from earlier community R&TD and projects of the Middle Eas t Desalination Research Center (MEDRC) on the use of RE for de-central water and power, the Consortium proposes an SSA on the RE and water supply related topics in SP1-10 Objectives B 1.3 and B 1.5. The main SSA objective is the transfer and disseminati on of know how and tools for systems analysis on the appropriate integration of RE technologies with de-central water and power services under local conditions of MPC. The action scope comprises: 1: exemplary studies on the integration of (hybrid) RE con version with combined water and power supply to villages and rural areas 2: identification of opportunities and conditions for economically and socially sustainable deployment of hybrid RE technologies in MPC, 3: training and capacity building in MPC i nstitutions for IWPP assessment services under local socio-economic conditions, 4: dissemination of results through the networks of the European Desalination Society (EDS) and MEDRC covering the MENA region. The capacity building shall be oriented to pla nning and assessment services and will include training of the MPC participants in using RESYSproDESAL for exemplary case studies in their countries. The SSA concept is open for later extension to the participation of R&TD institutions and water an d power authorities from other MPC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Agent based mobile access to information services' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Main Objective AMASE will investigate techniques for enhancing an existing agent platform to support stationary and mobile agents for wireless mobile communication environment. The project will focus on:  -High degree of user mobility between various networks, devices and physical location.  -Small and mobile devices for PC, personal digital assistants and GSM with SMS transmit and receive capabilities. The main goals are:  -to design, specify and implement the AMASE agent environment.  -to verify and demonstrate, with an agent-based application, the technical and economic suitability of agent technology for commercial wireless mobile applications. AMASE Scenario Technical Approach The project distinguishes between the agent environment (Agent Facilities plus Communication Facilities) and the agent-based application. Step 1 - Specification of the Mobile Agent Facilities The differences between the agent systems prevent interpretability and proliferation of agent technology. In order to promote both interoperability and system diversity, the project will review the emerging OMG MAF specification where it is applicable in the AMASE Agent Facilities. Additionally the specification of the AMASE Communication Facilities will be based on the MASE specification of the OnTheMove project. Step 2 - Enhancement of an Existing Agent Platform for Wireless Mobile Applications AMASE will use the Siemens SWARM Platform as the starting point. The SWARM system is fully written in JAVA, known within the consortium, and the source code is available. The platform enhancement development will support secure and efficient agent operations, cost-effective adaptability to wireless network characteristics, high degree of user mobility, high degree of scalability for various device platforms, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Beyond the hydrodynamics horizon in the evolution of small and large colliding systems at colliders' (KineticTheoryQGP) targeting Horizon Europe.

assistant: **Abstract**

A hot expanding environment is produced in heavy-ion (e.g., lead-lead or gold-gold) collisions in the Large Hadron Collider (LHC) and Relativistic Heavy Ion Collider (RHIC). The produced system expands and cools down, turning from a phase with liberated quarks and gluons, called quark-gluon plasma (QGP), to hadrons, detectable in the detectors. The QGP behaves like a nearly perfect fluid that can be modeled via relativistic hydrodynamics with the smallest observed shear and bulk viscosity over entropy density. In the course of the collective expansion, the degrees-of-freedom interaction develops correlation, reflected in the correlation among final hadrons. Models based on hydrodynamics successfully describe the observed correlations in the experiments. Observing a similar correlation among final hadrons emitted from much smaller collision systems, e.g., proton-proton and proton-lead, has triggered debates about the nature of the collectivity in such scenarios. Studies show that the models based on hydrodynamics become less predictive in smaller system collisions. In these systems, one does not expect a thermalized medium, and a framework beyond hydrodynamics is required to explain the true underlying mechanism in collective expansion.  The main objective of the current project is to prepare a computational tool in the form of an event generator based on the kinetic theory with isotropization time approximation. Among an extensive list of heavy-ion collective models, this event generator will be unique in explaining small systems that behave particle-like and large systems that act fluid-like in a single framework. The model can bridge the experimental measurements and theoretical studies to quantitatively analyze the fluid-like/particle-like nature of large and small s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Analysis, control, and engineering of spatiotemporal  pattern formation'.

assistant: **Innovation**

A central problem in developmental biology is to understand how tissues are patterned in time and space - how do identical cells differentiate to form the adult body plan? Patterns often arise from prior asymmetries in developing embryos, but there is also increasing evidence for self-organizing mechanisms that can break the symmetry of an initially homogeneous cell population. These patterning processes are mediated by a small number of signaling molecules, including the TGF- superfamily members BMP and Nodal. While we have begun to analyze how biophysical properties such as signal diffusion and stability contribute to axis formation and tissue allocation during vertebrate embryogenesis, three key questions remain. First, how does signaling cross-talk control robust patterning in developing tissues? Opposing sources of Nodal and BMP are sufficient to produce secondary zebrafish axes, but it is unclear how the signals interact to orchestrate this mysterious process. Second, how do signaling systems self-organize to pattern tissues in the absence of prior asymmetries? Recent evidence indicates that axis formation in mammalian embryos is independent of maternal and extra-embryonic tissues, but the mechanism underlying this self-organized patterning is unknown. Third, what are the minimal requirements to engineer synthetic self-organizing systems? Our theoretical analyses suggest that self-organizing reaction-diffusion systems are more common and robust than previously thought, but this has so far not been experimentally demonstrated. We will address these questions in zebrafish embryos, mouse embryonic stem cells, and bacterial colonies using a combination of quantitative imaging, optogenetics, mathematical modeling, and synthetic biology. In addition to providing insight