RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'VINYL AND HETEROARYL BORONIC ACIDS AS NON-STABILIZED NUCLEOPHILES IN RHODIUM-CATALYZED DYNAMIC KINETIC TRANSFORMATIONS' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The formation of carbon-carbon bonds in an asymmetric fashion is a very useful process in synthetic chemistry, since it generates single enantiomers of chiral molecules at the same time as the molecular framework is being assembled. In this context, two strategies for the generation of single enantiomer compounds using enantioselective catalysis have been widely emabraced: on the one hand, the use of prochiral substrates, and on the other hand, the use of racemic substrates in enantiomer resolution processes, which limits the yields up to 50%. An efficient variation of this second strategy is to couple enantiomer differentiation with interconversion of enantiomers. However, these  dynamic kinetic asymmetric transformations (DYKAT) have been limited to the use of stabilized nucleophiles. Very recently, the group of Fletcher reported that alkylzirconium reagents can be employed as non-stabilized nucleophiles in combination with a copper-based catalytic system for this class of processes. Subsequently, the same group demonstrated that arylboronic acids are also suitable substrates in rhodium-catalyzed DYKATs. The project presented in this application aims to expand the scope of this powerful transformation by using vinyl- and heteroarylboronic acids as non-stabilized nucleophiles in the rhodium-catalyzed DYKAT. Moreover, a thorough study of the reaction mechanism will be conducted, as well as the investigation on alternative procedures for this process (catalytic systems, nature of the substrates, etc) that might result in useful applications for organic synthesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Detailed binding scheme and structural determination of the 14-3-3ζ in complex with a double phosphorylated  human tyrosine hydroxylase 1' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

14-3-3 proteins, found in all eukaryotic cells, are known to be important in cell-cycle regulation, apoptosis, and regulation of gene expression. They are also associated with oncogenic and neurodegenerative amyloid diseases. 14-3-3 proteins are active as homo- or heterodimers and bind more than 850 diverse target phosphoproteins, thereby forcing conformational changes or/and stabilizing active conformations in their target proteins. To date, no crystal structure is known for a 14-3-3 dimer in complex with a doubly phosphorylated target protein; this prevents a full understanding of the 14-3-3 molecular mechanism.Spatial structure of human tyrosine hydroxylase 1 (hTH1) regulatory domain in apo form and in the complex with 14-3-3 ζ will be determined. The structured region of the hTH1 regulatory domain (~10kDa) in apo form will be solved by conventional NMR approach. Much more challenging  structure in the complex with 14-3-3ζ (~75kDa) will be solved by applying of the methyl-transverse relaxation optimized NMR spectroscopy on a deuterated 14-3-3ζ protein with protonated methyl groups of Val, Leu and Ile. Exposed side-chains of 26 Val, Leu and Ile residues will serve as reference points for the intramolecular NOEs between a double-phosphorylated hTH1 (dp_hTH1) and 14-3-3ζ dimer. This approach will be combined with the restrained molecular dynamics simulation for phosphorylated residues and a novel Hamiltonian replica exchange, using soft-core interactions developed by myself and Dr. Oostenbrink. The obtained structural ensemble will be refined based on the measured NMR data. Moreover, a detailed scheme of binding between dp_hTH1 and 14-3-3ζ will be determined.The proposed approach will have general applicability to most doubly phosphorylated 14-3-3 protein ligands. The r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Defining the Role of Flap Endonuclease 1 Conformational Dynamics in Catalysis'.

assistant: **Concept**

Flap endonuclease 1 (FEN1) catalyzes the removal of 5’-flap structures generated by strand-displacement synthesis during lagging-strand DNA synthesis and long-patch base excision repair. Homozygous knockout of FEN1 in mice is embryonically lethal, whereas haploinsufficiency or catalytic deficiency due to mutation leads to rapid tumor progression, thereby illustrating the importance of FEN1 to genome stability. Despite its critical role in DNA replication and repair, a detailed mechanistic understanding of how FEN1 enzymes achieve substrate specificity and scissile phosphate selectivity without sequence information is still poorly understood. Detailed kinetic studies from the laboratory of Dr. Jane Grasby suggest that a concerted enzyme-substrate conformational change is essential to create a cleavage-competent FEN1-substrate complex. Testing such a hypothesis requires an arsenal of molecular, chemical, kinetic, biophysical, and structural techniques. Although such studies are already underway in the Grasby laboratory, one powerful tool missing from the ‘Grasby arsenal’ that would greatly compliment her current work is NMR relaxation dispersion (RD) experiments, which can identify at the atomic level sites in and quantify the time scale of motion. Combining NMR-RD data with biophysical data routinely obtained in her lab would allow for direct correlations between observed rates of reaction and conformation exchange processes occurring in the protein and substrate as has been done for RNase A. Although the University of Sheffield has the instrumentation and protein NMR expertise of Dr. Jeremy Waltho, the presence of a researcher experienced in both NMR and enzymology would increase the chances for success of and greatly expedite the completion of the project. As a graduat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'A novel approach to non-toxic treatment of textile'.

assistant: **Innovation**

The project addresses a totally new concept in textile treatment: non-toxic treatment at substantially reduced cost with virtually no hazardous waste. Risk of the Project is quite high but will be well estimated during the exploratory phase as it is justified by a significantly reduced cost of the treatment and unimproved quality of the products. The indirect benefits are: improved quality of the treated textiles, improved working conditions for the European workers who are in contact with treated fabrics. A return on investment is 1.5 years following the implementation of commercial exploitation. The major idea behind the method into builds a novel plasma system for textile treatment (no similar system currently exists). Technology validation to a wider groups of Sees along with process development will need after 1.5 years after completion of the research project and a further period of 1.5-2 years prior to manufacturing and commercial exploitation of the new technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Global cycles of Ca and Mg using Ca and Mg isotope ratios during continental weathering' (2002-2006).

assistant: **Concept**

This proposal is for a Marie Curie EIF to work in the Isotope Geochemistry laboratory of the Department of Earth Sciences at the Swiss Federal Institute of Technology, ETH Zurich for 24 months.  This project proposes the combined analysis of Ca, Mg, Si and Li isotope ratios in rivers and soils to better constrain the global biogeochemical cycles of these elements. Ca, Mg and Si are some of the most abundant elements on Earth and some of the most geologically important because of their role in biogeochemical cycles. The project has two aims:  1. To better constrain the processes affecting Ca, Mg and Si in the weathering environment,  2. To improve modelling of the global budgets of Ca and Mg.  It is anticipated that the analyses and subsequent modelling will also be of interest to a variety of research areas from paleoclimatology, paleoceanography, to soil and agriculture sciences.  The project will:  1. provide advanced training in multi-disciplinary research areas such as oceanic cycles, chemical alteration of the continents and geochemical modelling, diversifying present experience, and gain expertise in mass spectrometry in a world-class isotope geochemistry facility.  2. strengthen cooperation between research groups in the EU and Switzerland through transnational mobility.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Transgenic models of mammalian meiotic exit' (2007-2013).

assistant: **Innovation**

Fertilisation occurs when two highly specialised cells (sperm and egg) unite, causing an 'awakening' of the egg, known as meiotic exit. During meiotic exit, a one-cell embryo (zygote) is formed that is totipotent - it can give rise to an entire individual. Given the fundamental nature of this event, it is remarkable that almost nothing is known about the regulation of meiotic exit in mammals. Ignorance about meiotic exit can and must be addressed; the mechanisms that underlie the period of meiotic exit impact all changes in cellular potency, including those predisposing to cancer and rationales for deriving induced pluripotent stem (iPS) cells and the emergent field of regenerative medicine in general. The present proposal addresses this gap in our understanding in mice that carry specified gene additions; transgenic mice. We propose to build new transgenic mouse models to study meiotic exit. They will uniquely allow us to visualise and manipulate the underlying processes that immediately follow fertilisation, including key meiotic events that include cytoskeletal rearrangement, cell cycle progression and chromatin remodeling. IRG support will accelerate acclimatisation and thereby foster reintegration of the applicant's laboratory following transition from RIKEN, Japan, to the Centre for Regenerative Medicine, Bath University, UK, after a 13 year absence from the EU initially supported by an EMBO Long Term Travel Fellowship to the US in 1996. Reintegration will strengthen the EU in powerful technologies, including piezo-actuated microinjection, and facilitate improved and novel approaches to the prescriptive genesis of stem cells such as iPS cells and research into cancer mechanisms. It will consolidate and extend collaborations within the EU, with Asia and beyond and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'SUPRA-NATIONAL INTRODUCTION OF COMPUTER-AIDED ENVIRONMENTAL MANAGEMENT AND INFORMATION SYSTEMS TO NEW INDUSTRIAL SECTORS AND USERS' under Fourth Framework.

assistant: **Concept**

The EU-programme 'Towards Sustainability' underlines the role and responsibilities of industry, both to reinforce the economy and to protect the environment. The EU-Eco-Audit-Regulation (1993) specified these tasks in detail and assigned clear responsibilities to industry to manage the environmental impact of its activities and to adopt a proactive approach in this field. LMS Environment had been working for 4 years to develop CAEMIS - a computer-based support system for environmental management in industry. Based on close co-operation with industrial companies and partially funded by the Austrian Government, LMSE continually improved the system to meet the user demands and has completed several pilot installations. With the introduction of the EU-Eco-Audit-Regulation (EMAS), demand for systemised methods and support tools has significantly increasing throughout Europe.This project was aimed at the transfer and dissemination of the CAEMIS system, by offering the chance to prove the flexibility and robustness of the system in further industrial applications at European level. The pilot sites for testing of the innovation were in three different sectors of industry in Denmark, Spain and Ireland. The technology assimilation took place in the respective countries via intermediary partners from consultancy and applied research organisations. Using their localised expertise, the system was adapted to the individual types of organisation, national legislation as well as local language. All systems will support compliance with EU regulations.The system consisted of 8 integrated modules covering environmentally related tasks on the technical operating level (e.g. waste and hazardous materials management, pollution control, management of provisions and permits) as well as on the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Joining up Users for Maximising the Profile, the Innovation and the Necessary Globalisation of JIVE' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

“Joining up Users for Maximising the Profile, the Innovation and the Necessary Globalisation of JIVE” (JUMPING JIVE) aims to prepare and position European Very Long Baseline Interferometry (VLBI) for the SKA era, and to secure the role of JIV-ERIC in the European and global landscape of Research Infrastructures. On a European scale, the proposed activities will raise the profile of JIVE among scientists and operators of radio-astronomical facilities, by widely advocating its science capabilities and its role as research infrastructure provider within the international radio astronomy community. These activities will focus on outreach and on reinforcing science cases for the next decade. New partnerships will be pursued, and in addition JIVE will expand its potential user base by offering geodetic and enhanced astrometric processing. Finally, the possibility of the International LOFAR Telescope using the same ERIC governance structure in the future will be investigated. With respect to global VLBI, the aim is to place JIV-ERIC in a leading role in the definition of scientific and technical standards in the SKA era. JIVE will take charge of a number of operational interfaces that will be essential for truly global VLBI, and establish close connections with the African VLBI Network and the SKA as the main strategic partners for the next decade.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Therapeutic research in assisted conception' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

ABSTRACT Objectives:The Bioethics Convention of the Council of Europe will, for signatories who as yet have no legislation in the area, prohibit most fundamental research on the human embryo, but will permit research on embryos in relation to their development or in relation to the diagnosis of the most serious diseases. This is likely to have a most profound effect on embryo research in Europe and may encourage experimentation as therapeutic research, that is, research undertaken for the benefit of the individual in question. Because it may largely be undertaken in the context of routine clinical treatment, therapeutic research may not be subject to the same rigorous scientific and ethical scrutiny as non-therapeutic research. Moreover, in the area of assisted conception, experimental procedures which are undertaken ostensibly for the benefit of the embryo but, in reality, to provide the infertile couple seeking treatment with a healthy child, may have unexpected and unwanted long term effects.By means of two focused workshops this concerted action aims to review the current situation within member states with regard to legislation in the area of assisted conception and the extent of both therapeutic and non-therapeutic research being undertaken. The likely impact of the Bioethics Convention will be assessed and a report and recommendations made to the European Commission on whether there is a need for the harmonisation of ethical, legal or other regulation of therapeutic embryo research such as the standardisation of databases and procedures for collecting records so that future analysis of long term effects would be possible.keywordsHuman embryo, assisted conception, therapeutic research, ethics, legislation, regulation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Characterization of mecp2 function in rett syndrome'.

assistant: **Concept**

Ret Syndrome, an important cause of mental retardation in women, is associated with mutations in the gene encoding methyl- Cog binding protein. The aim of this project is to identify target genes whose expression is altered as a result of Mapco mutations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Safe Perception And Navigation for Autonomous Robots' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Mobile robotic automation is one of the fastest growing international markets. Applications are spread across a range of verticals including logistics, industrial, agricultural and maintenance industries, driven by the need to reduce costs for European providers to compete with alternatives in lower labour-cost areas.Furthermore, with the digital transformation of the European economy while the effective workforce is aging and shrinking , there is a significant drive to increase productivity and quality of highly repetitive low-skilled jobs by robotics. The major challenge that impedes growth of the mobile robotics market is the ability to navigate around unmapped territory . Additional factors are high initial cost and public acceptance.Safe Perception And Navigation for Autonomous Robots proposes a single module for safe and accurate navigation disrupting the mobile robotics market. SPANAR increases the mobile robots utilization potential at a lower cost than existing solution, whilst allowing for increased safety. Its unique combination of sensors and software opens up new markets, allowing for mobile robots in highly dynamic environments, in all-weather conditions, and with combined in- and outdoor functionality. To penetrate global markets, the module is sold to OEMs and tier 1 suppliers of mobile robotics through online sales and distribution. Manufacturing is done inhouse and through trustworthy partners capable of mass-production.Avular will investigate four sub-markets in this feasibility study: warehousing automation, last-mile delivery, inspection & maintenance, and agricultural robotics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Polariton condensates: from fundamental physics to quantum based devices'.

assistant: **Objectives**

Polaritons are quantum superpositions of light and matter which combine appealing properties of both: the high coherence of photons and the strong interaction (non-linearities) of electrons. With the report of their Bose-Einstein condensation in 2006, they stand as one of the most exciting semiconductor-optical system of today. Given their peculiar character, they encompass different interdisciplinary areas of research which spans from the physics of phase transitions, critical phenomena and strongly-correlated systems (superfuidity, superconductivity, etc.) to various branches of quantum physics (quantum optics, quantum information, etc.), till the possibility of building polariton-based optical logics for implementation of optical circuits; all exciting realms yet to be explored.The majority of the outstanding findings reported have been realised in structureless samples with no, or random, potential barriers for polariton states. This proposal aims at developing the polariton physics in the presence of designed and controllable potential landscapes which will allow the observation and study of a new series of phenomena related to the system's reduced dimensionality and out-of-equilibrium character.Strong of several and complementary techniques to realize such potentials in microcavities, both in my institute and in partnership with leading growers worldwide, I will explore three phases of prospective physics in the framework where the polariton flow can be controlled, driven, localised and guided. First, I will study transport and interferometry. Then, these straightforward upgrades on the polariton state-of-the-art will be used to design elementary devices, such as polariton transistors (classical logic) or entangling devices (quantum logic). In a final phase, polar