RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The origin of fitness: Tracing individual fitness differences to genetic variation in a wild bird population' in the context of a Seventh Framework call.

assistant: **Objectives**

Understanding how genes and the environment affect animal fitness is a central challenge in current evolutionary biology. Therefore, I propose a study to identify genes with strong effects on fitness in a wild bird population. To achieve this, I will make use of the unique opportunity offered by a study species with strong fitness differences between genetically distinct morphs and a recently developed sequencing technique which is the first to make such a study feasible.Restriction site associated DNA (RAD)-tags allow scanning previously unsequenced genomes and are expected to yield several thousand single nucleotide polymorphisms (SNPs) in the genome of the study species, the Common Buzzard Buteo buteo. This medium-sized raptor occurs in three colour morphs, which have been shown to differ in lifetime reproductive success in a 22-year study. Blood samples and phenotypic measurements have been collected from >1200 chicks over a nine-year period. Morph, reproductive success, survival, and other fitness-related traits such as body condition, fledgling date, and parasite infestation will be tested for association with individual alleles and genetic variability to identify genetic regions in disequilibrium with fitness-relevant genes. To identify candidate genes, marker regions will be searched for known genes, using the chicken genome as a reference.In addition, the genetic basis for a first phenotypic candidate trait, immunity, will be tested. MHC class II genes will be sequenced by using a new approach based on 454 sequencing with carefully controlled accuracy tests. Individual alleles and variability will be tested for correlations with parasite infestation, recruitment and other fitness-related traits.In the course of this study, I will acquire state-of-the-art, highl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multimedia Content in the Digital Age' to be submitted under Fifth Framework.

assistant: **Abstract**

The objective of the project is to set up a comprehensive R&D effort to cover the effects and possibilities of enabling multimedia technologies for the European media sector. The project will be a collaborative effort of experienced research institutes and international professional organisations, together with a range of European media. Key element is to analyse systematically the fundamental changes in the profession due to the emerging digital production and distribution technologies.Via a cluster of socio-economic studies, field surveys and trend scenario's, the consortium will establish a solid basis for innovative working methods and multimedia products. The outcomes will be widely disseminated. Various project activities will stimulate a climate of prompt action and joint ventures at the level of the European news industries: print, audiovisual and online. Initiatives to consolidate the project research effort will be taken.Objectives:The consortium will build a basis for innovation of working methods and the introduction of multimedia products in the European news industry. A cluster of related socio-economic studies will establish a first European-wide overview of ongoing developments in this field. The long-term consequences of the imminent overhaul to fully digital production conditions for content providers and information consumers will be translated into a set of future scenarios. Measures will be taken for the systematic collection of key data on multimedia products and innovative media strategies.The project will foster the viability of the European news production sector by:- bringing together the research and professional worlds- bridging traditional national divides and encouraging joint projects- strengthening the competitiveness vis-a-vis the intern
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Extracellular Vesicles Fiber Optic Surface Plasmon Resonance selection and analysis' (2021-2027).

assistant: **Concept**

The Extracellular vesicles (EV) field is growing due to increased interest in their roles in diagnostics and therapeutics. Current methods to purify and quantify EV’s take a long time, introduce a bias, are costly and imprecise, thereby hampering advancement in the EV R&D field, while the lack of methods to quantify EVs directly in crude samples restricts applications in diagnostic and bioprocessing. FOX has established a breakthrough label-free technology in a fiber-optic concept in an automated platform that allows biomolecular interaction research of biologicals. The FOx affinity isolation and simultaneous quantification with a sensor dip probe is a new, selective (no bias), automated (scalable 4x), faster (time/24) and specific (purity >95%) method that allows accurately quantifying EV directly from crude samples. Moreover, it allows for the first time to release the quantified and specifically selected EV’s for further quantitative content analysis.


**Keywords:** bioanalysis,Fiber optic,biosensing,advanced therapeutics,Extracellular vesicles,Cell and Gene Therapy,Bioreactor,vaccines
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Flexible polymer-based biophotovoltaic devices for green hydrogen production'.

assistant: **Objectives**

In view of the urgent need to mitigate the environmental effects caused by the large amounts of CO2 released into the atmosphere, alternative strategies for energy production using renewable sources (water, wind, biomass, sunlight) have been deployed. Green hydrogen (H2) is an alternative to fossil fuels due to its clean and high energy density combustion, but still limited the low efficiency of production and high cost. To respond to these limitations, BioH2Gen proposes an alternative strategy for green H2 production through biophotovoltaic (BPV) devices, taking advantage of photosynthetic microorganisms to generate H2 through sunlight capture. More specifically, this project proposes the development of new nanostructured photoelectrodes based on flexible polymeric scaffolds prepared by electrospinning modified with semiconducting conjugated polymers aiming at the construction of BPV devices through the interfacing with photosynthetic microbes (biophotoanode) and hydrogenase (biophotocathode). BioH2Gen addresses recent progress in the field and tackles this topic by deploying a multidisciplinary approach to develop an innovative solar powered H2 production platform. The structure, charge transfer kinetics, and band-gap design of new flexible photoelectrodes will improve biotic-abiotic interactions for charge transfer. Finally, a tandem BPV assembly and its incorporation into a photoelectrochemical cell architecture will be carried out, aiming at high solar-to-hydrogen efficiencies. The successful implementation of the research methodology will culminate in a sustainable alternative in BPV device development due to the lightweight, low-cost, and low-environmental impact of the materials employed in their construction.


**Keywords:** Bioelectrochemistry, Electrochemistr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Control of specification and migration of oligodendrocytes' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The study of cellular and molecular mechanisms underlying oligodendrocytedevelopment is a prerequisite to understand pathologies linked to myelin dysfunction. During development, the oligodendroglial specification of intraepithelial cells is a process spatially restricted which gives rise to a diversity of oligodendrocyte cells types. The aim of our project is to study, from multidisciplinary approaches (molecular and cellular) and in different animal models (Drosophilae, chick, mouse):i) the developmental mechanisms regulating the oligodendrogenesis from undifferentiated intraepithelial precursors: focusing on genetic cascade that controls the choice of oligodendroglial lineage; andii) the biological consequences of molecular and spatial differentiate characters of oligodendrocyte progenitors; focusing the migration patterns and their molecular control.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SeLf-powered self-rEshaping Autarkic skin For wireless motes - LEAF' (LEAF).

assistant: **Innovation**

We will combine 3D reshaping, energy harvesting, and energy storage within a single, thin foil. The thin foil of several micrometer thickness is going to be fabricated by inkjet and capillary printing on a temporal carrier support and consists of an adhesion sacrificial layer (own technology relying on lanthanum acrylic acid coordination polymer) and a strain inducing bilayer made of hydrogel and a stiffening layer (own innovation technology). The combination of specifically designed bilayer polymer system (polyethylene alt maleic anhydride type hydrogel and polyimide materials) is able to reshape into Swiss-roll architectures with few hundreds of micrometer diameter through a selective etching of the sacrificial layer and swelling of the hydrogel in a water-based solution. We will implement high precision capillary printing (HPCAP) to print dedicated structures with high control over length, thickness and separation with (sub-)micrometer resolution and high reproducibility of a variety of materials, which deliver different functionality. Self-powering of the autonomous device is ensured through the use of bi-functional materials deposited into interdigitated micro-electrode structures, function as light converter and storage materials at the same time. The thus created photo-storage microscale supercapacitor is embedded onto the thin foil and will serve as autonomous power source for the integrated silicon chip. The 2D area of the ultrathin foil delivers maximized surface area of the interdigitated finger structure and ensures sufficient light absorption to power the integrated RFIC (e.g. an active tag/sensory system). The optimized weight (R ~ 0.95) will be granted by the ultrathin nature of the foil (around 5um), while mechanical stability of the final device is ensu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Doping on Demand: precise and permanent control of the Fermi level in nanocrystal assemblies'.

assistant: **Objectives**

The aim of the work proposed here is to develop a completely new method to electronically dope assemblies of semiconductor nanocrystals (a.k.a quantum dots, QDs), and porous semiconductors in general. External dopants are added on demand in the form of electrolyte ions in the voids between QDs. These ions will be introduced via electrochemical charge injection, and will subsequently be immobilized by (1) freezing the electrolyte solvent at room temperature or (2) chemically linking the ions to ligands on the QD surface, or by a combination of both. Encapsulating doped QD films using atomic layer deposition will provide further stability. This will result in stable doped nanocrystal assemblies with a constant Fermi level that is controlled by the potential set during electrochemical charging. QDs are small semiconductor crystals with size-tunable electronic properties that are considered promising materials for a range of opto-electronic applications. Electronic doping of QDs remains a big challenge even after two decades of research into this area. At the same time it is highly desired to dope QDs in a controlled way for applications such as LEDs, FETs and solar cells. This research project will provide unprecedented control over the doping level in QD films and will provided a major step in the optimization of optoelectronic devices based on QDs. The “Doping-on-Demand” approach will be exploited to develop degenerately doped, low-threshold QD lasers that can be operated under continuous wave excitation, and QD laser diodes that use electrical injection of charge carriers. The precise control of the Fermi-level will further be used to optimize pin junction QD solar cells and to develop, for the first time, QD pn junction solar cells with precise control over the Fermi l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Assessing, preserving and restoring man-microbes symbiosis' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The microbiomics revolution has favoured the recognition of the gut as a true organ and the importance of man-microbes symbiosis in health and disease. Derived from a long co-evolution the latter has been challenged by numerous environmental triggers, modern lifestyles, changes in birth modalities, nutritional transition and therapeutic attitudes. A large fraction of the human population has tentatively entered a man-microbes dysbiotic state characterized by altered interactions between microbiome and host features with auto-aggravating crosstalk signals. The result is increased incidence of incurable immune-mediated diseases of modern societies that affect a third the human population on earth today and for which current therapeutics only address symptoms alleviation, rather than considering man as a holobiont.In this context and its resulting threat for the human species, I will carry out a project geared to open a new era of individualized preventive care and novel gut ecology-based therapeutic approaches. The project will assemble insights and contributions from theoretical to experimental ecology, quantitative and functional microbiomics, preclinical work, cohort studies and clinical trials, so as to:•Validate the concept of critical transition and alternative stable state as it applies to a shift from man-microbes symbiosis to disease-prone man-microbes dysbiosis •Assess the potential of diet alone to promote such a shift •Model the symbiosis-to-dysbiosis transitions and derive predictors of tipping points •Propose counter-measures that may allow to break vicious circles and restore a balanced, health-prone, man-microbes symbiosis by concomitantly acting upon microbiome and host features•Validate strategies to reinforce ecological robustness and restore man-microb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Management of aquatic vegetation in the Lower Senegal River Basin' (1994-1998).

assistant: **Innovation**

The main objectives are as follows:* To assess the ecological changes in the Lower Senegal River Basin and related aquatic weed problems as a result of the construction of the Diama dam near the outflow of the river, with emphasis on the Lac de Guiers.* To study and assess the effect of the weevil Neohydronomus affinis on Pistia stratiotes (water lettuce) in the Lac de Guiers and the Djoudj National Park.* To study and assess the effect of mechanical control of aquatic weeds (mainly Typha australis) in the Lac de Guiers and the Djoudj National Park.* To come to an effective integrated control programme of aquatic weeds in the Lower Senegal River Basin by using biological means of control (N. affinis against P. stratiotes) as well as mechanical means of control (mowing boat for removing emergent weeds).Expected OutcomeAn ecologically sound, effective integrated control method for aquatic weeds in the Lower Senegal River Basin in Senegal and Mauritania, as well as detailed knowledge of the development of aquatic vegetation in the Lac de Guiers.The key activities envisaged are:* Estimation of areas in the Lac de Guiers covered by aquatic vegetation (including species composition) during three years via satellite images, modern GIS methods including colour photo CD's combined to a MapInfo programme and estimations in the field using GPS.* To study physical/chemical characteristics of the water, such as pH, redox-status, conductivity, secchi depth and bottom quality.* Rearing and subsequent release of the weevil N. affinis in the Djoudj National Park and the Lac de Guiers, as well as monitoring the impact of the weevil on the development of Pistia.* Assessing the effect of a mowing boat on emergent aquatic weeds, in particular T. australis. This will imply mowing at differen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Network of National Contact Points for the five EU Missions' (NCP4Missions).

assistant: **Concept**

NCP4Missions is a networking project of National Contact Points (NCPs) for the five EU Missions, representing 19 Member States or Associated Countries (MS/AC). The project provides continuous capacity building measures for NCPs (e.g. E-learnings, Deep Dives, Meet&Share, Mission Updates) to support less experienced NCPs and to provide more consistent Mission NCP services to applicants. Adding to this, brokerages, workshops and digital tools are offered to potential Mission applicants. The project will establish important collaborations with all relevant Mission stakeholders (e.g. Mission Hubs, Mission Implementation Platforms, NCP networks) to detect synergies and to foster potential joint activities.The projects’ activities pursue the following objectives:•Improving and professionalizing NCP support services for the EU Mission Calls •Lowering entry barriers for applicants and raising the quality of proposals •Enhancing the visibility of the Mission NCPs and the cooperation with other relevant stakeholders and networksLong-term impacts can be expected in the fields of policy, science and society. As NCP4Missions will function as interface between the European Commission (EC), MS/AC and the NCPs, a better exchange of information on the EU Missions will be triggered. This will affect political decisions on EC and national level in support of the implementation of the Missions. The consistency of NCP support services in Europe and beyond will lead to more equal opportunities of applicants of different countries. Through an enhanced knowledge base on Missions in R&I organisations, higher participation rates and a better quality of Mission-tailored proposals can be expected, resulting in innovative projects. Awareness raising and civil engagement activities will impact the en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identification and in vivo functional analysis of novel cell surface receptor-ligand pairs' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Intercellular communication and adhesion are involved in many developmental processes of multicellular organisms. An increase in anatomical and physiological complexity of organisms is accompanied by an expansion of gene families encoding proteins that are involved in cell-cell recognition and signalling. Prominent examples are the members of the IgSF family, which encountered a fivefold numerical increase in vertebrates compared to invertebrates, despite the total number of genes only doubling. The identif ication of novel receptor:ligand pairs of this gene family and their in vivo functional analysis would further our knowledge of vertebrate specific developmental processes. To achieve this goal, we propose to take a genome wide approach by using the zebraf ish as a model organism. This approach will be carried out in the host laboratory of Gavin Wright at the Sanger Institute and comprises the identification of genes encoding cell surface proteins of the IgSF family (by using information from the Sanger Inst itute zebrafish genome project), the detection of novel receptor:ligand pairs among them, and the assessment of their in vivo function by means of a reverse genetic approach in zebrafish. The host institution provides an ideal scientific environment to ach ieve the mentioned objectives. The applicant will provide his expertise concerning the use of the zebrafish as a genetic model organism, whilst the host institute will provide the necessary infrastructure, equipment and expertise within in the fields of bi ochemistry and proteomics. The proposed project will therefore contribute to the exchange of knowledge between two European countries coupled to the fact that the whole genome approach to be taken is particularly suitable to establish further long-term col la