RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Directed Evolution of Artificial Metalloenzymes for In Vivo Applications' (DrEAM).

assistant: **Concept**

In the past decade, artificial metalloenzymes (AMs) have emerged as an attractive alternative to the more traditional enzymes and homogeneous catalysts. Such hybrid catalysts result from the incorporation of an abiotic metal cofactor within a macromolecule (protein or oligonucleotide). Artificial metalloenzymes combine attractive features of both homogeneous catalysts and enzymes, including the possibility to genetically optimize the catalytic performance of new-to-nature organometallic reactions. Can artificial metalloenzymes become as catalytically efficient as naturally-evolved metalloenzymes, even in complex biological mixtures? Herein, we outline our efforts to address this challenge by localizing and evolving AMs within the periplasm of Escherichia coli. To achieve this objective, we will exploit AMs based on the biotin-streptavidin technology. Four subprojects have been tailored to address the challenges: i) knock-out deleterious components present in the periplasm; ii) improve the cofactor uptake through the outer-membrane; iii) engineer streptavidin to boost the AM’s performance; and iv) rely both on screening and selection strategies to evolve AMs in vivo. Relying on auxotrophs, we will demonstrate the potential of AMs to complement metabolic pathways. Only E. coli auxotrophs containing an evolved AM capable of producing the vital aminoacid-precursor will survive the stringent selection pressure. We have identified several selectable aminoacid precursors which can be produced by metathesis (indole, precursor of tryptophan), enone reduction (keto valine, precursor of valine) and allylic substitution (prephenate, precursor of tyrosine and phenylalanine). In a Darwinian evolution spirit, we anticipate that applying selection pressure will allow to evolve AMs to u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dermography. Ethics and Aesthetics of Skin Writing' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

We are only just now beginning to understand the importance of human skin for our individual and collective well-being. According to biophysicist Georges Limbert (2019), “skin tells a story about our health status, age, past traumas, emotions, ethnicity and our social and physical environment”. As the oldest and most sensitive of our organs, it provides us with powerful collective mental images of both intimacy and integrity. Just as in the Freudian ‘Wunderblock’ (mystic writing pad), it remembers and records our personal biographies and traumas. Skin, in other words, is closely related to writing. Within literature skin has always been a special canvas that allows the study of cultural and societal phenomena. Accordingly, literature plays a crucial role whenever we try to analyze and understand the cultural and societal role of skin. Rooted in comparative literary studies, “Dermography. Ethics and Aesthetics of Skin Writing” [DEAS] integrates cultural, medical and intellectual history with archives of actual skin samples, ethics and psychoanalysis and relates its findings to contemporary biophysics and the life sciences, including the health and beauty industries. As a literary project, DEAS will put various skin narratives and skin writing (dermography) into context while at the same time taking into account skin’s materiality in a concrete sense: Working with actual skin samples and artificial skin research has never been done before in a literary context. Exploring the unique collection of the Medical Museion in Copenhagen, one of the largest of its kind, and integrating it in research that goes far beyond its archival significance, is a pioneering approach that challenges both traditional literary scholarship and curatorial methods. By focusing on the affinity of s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Social Capital, Quality of Life and Information Society Technologies: Evidence-based dynamic modelling support for the IST Priority' under Sixth Framework.

assistant: **Concept**

This action will support IST policy and RTD optimising the positive effect of IST development on social capital and quality of life. For this purpose a decision support software tool will be developed that shows the effect of IST on the development of social capital and quality of life. This tool will be based on a validated system dynamic model that is a condensation of the state-of-the-art knowledge about the issue. The current knowledge about relationships between IST, social capital and quality of life will be supplied by a meta-analysis in the beginning of the project, in which all relevant literature and datasets will be reviewed. Based on these results the system dynamic model will be constructed and internally validated by analyses on the available datasets. An external validation will be carried out by working out the implications of the model for some topics selected by a special interest group in which interested experts with different backgrounds in policy, RTD, especially other FP6projects, or IST industry are represented. In three seminars the results of the meta-analysis, the tool and the analyses on the selected topics will' be presented to this special interest group. Also the implications of the results will be discussed in the seminars. The interactive set-up of the seminars will provide feedback enabling the project to deliver a usable and useful decision support software tool (MS-Excel application) that could immediately bring into action in the working practice of specialists in policy, RTD or IST industry. In the last seminar a policy and RTD agenda will be discussed with recommended actions to optimise the positive effect of IST development on the actualisation of social capital and quality of life and to evolve the special interests group into a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Semantic Data Management' under Seventh Framework.

assistant: **Concept**

Semantic data management refers to a range of techniques for the manipulation and usage of data basedon its meaning. Semantically enabled linked and open data have been published at an increasing pace inrecent years, and this technology has been adopted by major industrial players, including Google, Yahoo,Oracle, Talis and IBM. But to reach their full potential of becoming a transformative technology enablinga data-driven economy, there are important research challenges related to semantic data, particularlyregarding maturity, dynamicity and the ability to process efficiently huge amounts of interconnectedsemantic data. SemData brings together some of the internationally leading research centres in the area ofmanaging semantic data to address these challenges.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'DEVELOPMENT OF DIAMOND INTRACELLULAR NANOPROBES FOR ONCOGEN TRANSFORMATION DYNAMICS MONITORING IN LIVING CELLS'.

assistant: **Concept**

Dynamic information about biomolecular processes in living cells is important for fundamental understanding of cellular functions, which is one of the primary targets of molecular cell-biology with important applications to pharmacology. However fur further progress in this field, and this specifically for monitoring genomic processes, there is immense need for developing sensing and detection techniques that can operate with sufficient submicroscopic resolution inside the living cells and bringing real-time information about local biomolecular interactions. The present proposal makes a further, large step towards integration of forefront nanotechnology, chemistry and molecular biology expertise with a common goal of studying intracellular processes during the evolution steps of several types of frequently occurring cancers. This will create a novel tool studying the molecular processes in cells on nanoscale, which is the objective of this call. The aim of the DINAMO project is to develop the nanodiamond particle (NDP) non-invasive label-free nanotechnology platform for real-time monitoring (1) of living cells modified by oncogenic impact, (2) of the kinetics of gene-assisted processes in the cells. Based on the development work of DINAMO, we propose to apply to apply luminescent and single spin detection techniques for real-time dynamic monitoring of biomolecular processes in cells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Persistent Awareness system facilitating Customs ChecKs' (PACK).

assistant: **Concept**

By combining IoT solutions with edge-based AI, our project PACK significantly decreases the number of trucks to be stopped for checking, enables fully automated customs checks, improves energy efficiency by optimising the equipment to operate autonomously with minimal environmental impact. It aims to deliver a highly secure, cyber-resilient access control system specifically designed for the cargo compartments of freight trucks. This innovative system enhances and integrates advanced detection, tracking, and risk-based selective control systems, featuring trustworthy algorithms that reduce false positives and biases. PACK brings more efficient customs control processes by a smart IoT-enabled customs seal to deter tampering and an intelligent IoT sensor array equipped with edge-based AI for continuous monitoring. With this setup, the system can independently evaluate the need to issue alerts to supervising authorities, thereby streamlining roadside inspections. Additionally, it allows customs and law enforcement agencies to access and unlock the customs seal at any point during transit, including locations outside traditional customs yards and checkpoints. Our goal is to demonstrate that implementing PACK across the European Union can significantly reduce freight truck waiting times at external EU borders, by just a 10% market penetration saving the logistics and transportation industry ~ €241 million and 2.35 million hours of time annually. This improvement would also result in the conservation of ~70.5 million litres of fuel annually, reducing CO2 emissions by approximately 190.000 metric tons each year. The complete solution will be validated with end-users in realistic operational scenarios, running parallel to actual customs inspections to benchmark its performance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Production and characterisation of synthetic inhibitors of parasite ofproteases as drug candidates for the predominant protozoal diseases SouthAmerica and other developing regions' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

To develop specific inhibitors of parasitic cysteine proteases as drug candidates for the treatment of the predominant protozoal diseases (in particular Leishmaniasis and Chagas disease) of South America and other developing countries. This goal will be attained through the implementation of molecular biology, enzymology and state of the art combinatorial chemical library techniques.Expected OutcomeSince the chemotherapeutic treatment of parasitic diseases is not satisfactory because of drug toxicity and the development of drug resistant parasites, the development of alternative drugs is of grave import. By the end of this project, we will have developed a new class of antiparasitic drugs. Simultaneously, we will have deepened the understanding of the mechanism and specificity of CPs and the mode of action of various parasites. Moreover, we will have established a multidisciplinary, international research network to foster innovations in the drug discovery approach.Solid phase chemical synthetic methodology will be developed simultaneously with molecular and recombinant technology which will generate large quantities of cysteine proteases for screening. An iterative process of screening and optimization will lead to the target drug candidates. The measurable objectives are outlined as follows in quasi-chronological order.* The development of resins suitable for both synthesis of non-peptide inhibitor libraries as well as solid fluorescent-quenched enzymatic assays.* The isolation of recombinant and native Leishmania cysteine proteases (CPs) in large amounts.* The determination of substrate specificity of recombinant cruzipain and important Leishmania CPs using substrate libraries and MS detection.* The development of several methods (nanoprobe MAS-NMR of single beads, M
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advanced Tools and Research Strategies for Parasite Control in European farmed fish' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

European aquaculture production provides direct employment to 80,000 people and a 3-billion € annual turnover. Parasites cause severe disease outbreaks and high economic losses in finfish aquaculture. The overarching goal of ParaFishControl is to increase the sustainability and competitiveness of European Aquaculture by improving understanding of fish-parasite interactions and by developing innovative solutions and tools for the prevention, control and mitigation of the major parasites affecting Atlantic salmon, rainbow trout, common carp, European sea bass, gilthead sea bream and turbot. To achieve these objectives, ParaFishControl brings together a multidisciplinary consortium comprising 28 partners possessing world-leading, complementary, cross-cutting expertise and drawn from public and private research organisations, and the aquaculture industry. The consortium has access to excellent research facilities, diverse biological resources including host-parasite models, and state-of-the-art vaccinology, genomic, proteomic and transcriptomic technologies. The project will: 1) generate new scientific knowledge on key fish parasites, including genomics, life-cycle, invasion strategy and host-parasite interaction data, with special emphasis on host immunity, pathogen virulence and immunomodulation, providing a scientific basis for improved prophylaxis; 2) determine the transfer of parasites between farmed and wild host populations; 3) develop a wide range of novel prophylactic measures, including vaccines and functional feeds; 4) provide a range of advanced or alternative treatments for parasitic diseases; 5) develop cost-effective, specific and sensitive diagnostic tools for key parasitic diseases; 6) assess the risk factors involved in the emergence, transmission and path
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovative Sensor for the fast Analysis of Nanoparticles in Selected Target Products' (INSTANT).

assistant: **Innovation**

INSTANT will face the challenge of the detection, identification and quantification of engineered nanoparticles (ENPs) in complex matrices such as cosmetic products and engineered food and drinks. Therefore, new detection methods and technologies are mandatory. This is completely in line with the Call FP7-NMP.2011.1.3-1 which deals especially with innovative, practically implementable and cost effective measurement approaches for ENPs in complex matrices. Recently emerging ENPs include Ag, SiO2, TiO2, ZnO, and organic NPs. The “Opinion of the Scientific Committee on the Potential Risks Arising from Nanoscience and Nanotechnologies on Food and Feed Safety” released by the European Food Safety Authority (EFSA) (2009) also highlights the urgent need for such a tool. Accordingly, the interdisciplinary project INSTANT will develop an innovative and integrated technology for monitoring the exposure of consumers to ENPs using a label free opto-electrochemical sensor array in combination with novel recognition elements.The SME driven INSTANT will develop an innovative, cost effective, and easy to use analytical tool to extract, detect and identify ENPs typically used in cosmetic products (e.g. sunscreen, toothpaste, deodorant, ...) and engineered food (e.g. instant soups, ketchup, ice cream, ...) and drinks (e.g. fruit juice, energy drinks, bottled water, ...). A crucial point of measuring in these complex matrices is the sample preparation and extraction. Therefore INSTANT will develop and integrate tailored extraction methods. Especially the size distribution of ENPs in the sample and the influence of the matrix on chemical and physical properties of the ENPs have to be taken into account. The INSTANT device will be designed to be used as a cost effective monitoring tool whic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Analytical and computational centre for ore deposit research' (1998-2002).

assistant: **Concept**

Applications are invited from PhD students from eligible states, for research training at the ACCORD Training Site. The Site is located in South Kensington, London linking 'The Natural History Museum (NHM) and the Geology Department of Imperial College (IC) and is funded by the EC IHP Programme. Training will be provided in state-of-the-art analytical techniques and computational modeling methods for ore-deposit research in four specific areas: Mineral characterization, Fluid inclusion study, Geochemistry and Complex system numerical modeling. Students undertaking work in these areas will be supervised and trained by leaders of groups in these fields. Fellows will be able to enroll in specialist IC courses related to their research and in personal development courses, and will be encouraged to interact with professionals from international mining companies and academe. Participants will be expected to achieve the goal of submitting a manuscript to a major international journal and to present their research at industry-academic seminars held in South Kensington. Visitors will have full access to the facilities at IC and NHM. 4 Fellows per year will benefit from the scheme. Visits can last between 3 and 12 months. Provision will be made for travel and subsistence. In the first instance, applicants are advised to discuss their project requirements with the ACCORD staff prior to submitting applications. Further information on forms can be found at: http://www.nhm.ac.uk/mineralogy/research/NHM's policy is to provide equal opportunity for employment, career development and promotion to all who are eligible, on the basis of ability, qualifications and fitness for work. Applications are welcome from all qualified individuals irrespective of disability, age, race, gender or mari
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrated Quantum Optics with Waveguides' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The present proposal will fund an experimental project which aims to implement optical quantum information devices on a solid state substrate. Optical waveguides will be used for the fabrication of different circuits that will be designed for the generation of nonclassical light sources, and reconfigurable linear circuits. Lithium niobate and lithium tantalate will be used as substrates for the fabrication of the guiding structure since they provide high second-order nonlinearity and a transparency range that goes from infrared to blue light. The two crystals are also compatible with the reverse proton exchange technique that will be used for the fabrication of high quality optical waveguides. Nonclassical light sources will be realized by spontaneous parametric down conversion in periodically poled waveguides. Different sources, such as squeezed vacuum and photon pairs, will be produced with innovative optical guiding configurations that are extremely compact and stable. Reconfigurable linear circuits will be fabricated using variable beamsplitters that can be externally controlled via the electrooptic effect. This basic structure will be the building block of a reconfigurable circuit that will be able to perform deterministic unitary transformation and probabilistic nonlinear operations. The final step of the proposal is the implementation of a completely integrated quantum circuit, from source to gate, all on the same chip.