RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The aged myocardium - response to hypertrophic and fibrotic stimuli' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Aged patients suffer more frequently from systemic hypertension and heart failure after myocardial infarction as reflected by increased morbidity and mortality. A diminished arterial compliance, a compromised capacity of myocardial adaptation due to altered electrophysiological and mechanical properties of the myocardium and changes in the molecular response during stress-induced signalling, all concur to worsen cardiac pathophysiology in ageing. Chronic haemodynamic stress initiates a complex programme at the cardiovascular level. This 'ventricular remodelling' features a progressive increase of surviving cardiomyocyte dimension (cellular hypertrophy), an enlargement of chamber volume (dilatation), an augmented deposition of extracellular matrix proteins in replacement of necrotic cardiac cells (reactive fibrosis), around vessels (perivascular fibrosis) and in the interstitium (interstitial fibrosis). The specific responses of the senescent heart to hypertrophic and fibrotic stimuli remain still poorly defined in terms of hormonal homeostasis, regulation of transcription for the proteins involved in ventricular remodelling and functional evolution after insult. Therefore, in the present project, the relative importance of haemodynamic factors versus circulating hormones in promoting myocyte hypertrophy or fibrosis in cardiac pathologies will be evaluated. This will be investigated by submitting animals to hypertrophic stimuli of prevalently hormonal origin (continuous Beta-adrenergic stimulation) or experimental models combining hypertension and hormonal stimuli (coarctation of abdominal aorta).The response will be analysed in terms of level and velocity of transcription of some selected genes activated during ventricular remodelling, collagen deposition in the ventric
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New forms of sustainable urban transport and mobility', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Mobility for each citizen as well as the transport of goods must be ensured in combination with a free choice of transport modes. However, actions of mobility management should be strengthened to raise people’s awareness towards sustainable mobility.Due to changing conditions (e. g demographic development, rising energy costs, new ecological standards) new quality standards for an attractive pedestrian, bicycle, and public transport infrastructure are on the urban agenda in many cities.The four cities Stuttgart, Brno, Malaga and Tel Aviv-Yafo decided to create more sustainable, clean and energy-efficient urban transport systems in their cities to establish new forms of mobility in a common approach for the benefit of all citizens, society and climate policy, respecting the environment and natural resources.The development and implementation of similar projects and initiatives in the four cities will allow evaluating and comparing the results and impacts in the different contexts in the leading and learning cities. In addition, the measures in the four cities have been selected in a way that allows transfer and applicability to small- and medium-sized towns.Specific emphasis has been given to the measures of e-mobility, freight and ITS-based traffic management. Also the continuous reflection of the proposed projects with the SUMPs as well as with urban development plans is stressed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Amorphous topological matter: Predicting new phases with enhanced properties in a vast pool of amorphous materials' (TOPOMORPH) targeting Horizon Europe.

assistant: **Abstract**

Discovering new phases of matter in materials with superior properties is a central goal of condensed matter physics.  Topological phases are a remarkable example: their robust and universal properties are key to groundbreaking technologies, notably robust quantum computation based on topological superconductors. However, our methodology to discover and classify topological materials relies heavily on crystal symmetry, thereby overlooking the largest, most affordable and scalable pool of materials - amorphous materials. Amorphous matter can outperform crystals, and is ubiquitous in technology: e.g. amorphous bismuth superconducts below 6K, a temperature 10,000 times larger than crystal bismuth, and amorphous silicon makes large-area solar cells affordable. This raises the fundamental question of whether we have overlooked new topological phases intrinsic to amorphous matter in materials with properties unparalleled by crystals. It is also unknown if any amorphous superconductor is topological. The core objective of this project is to harvest the superior properties of the vast pool of amorphous solids to find fundamentally distinct topological phases with high technological potential, via three specific goals: 1. Establish a predictive methodology to unlock the vast pool of amorphous matter to discover new topological materials. 2. Use this methodology to define unaccounted for amorphous topological phases with superior capabilities and no crystal analogues. 3. Use the above to predict the first amorphous topological superconductors. These goals will establish amorphous topological matter as a radically new direction to solve the challenge of finding novel platforms for topological superconductivity, where robust quantum computers can be based. This project will establi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Forever Open infrastructure across (X) all transport modes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

An efficient and high-quality transport infrastructure is a fundamental requirement for the connectivity of people and goods in Europe and basis for economic growth, competitiveness and territorial cohesion. In general, the transport network in Europe is of a high standard but is still fragmented regarding the geographical distribution and the transport modes.In recent years, first networking activities and exchange of strategic programmes among the stakeholders of the four transport modes – road, rail, water and air – can be noticed but still a mono-modal, mono-disciplinary culture exists. In the light of the future challenges, e.g. increasing transport demand, ageing infrastructure, scarcity of natural resources, changing climatic conditions, it is inevitable to strengthen the collaboration of the single transport modes in order to create an improved future integrated and functioning transport system for Europe, despite of limited financial resources of the owners of the transport network.The FOX project aims to develop a highly efficient and effective cross-modal R&D environment and culture which meets the demanding requirements of the transport and connectivity. Based on already existing programmes and agendas related to the aspects of co-modal transport research, the FOX project will identify common needs and innovative techniques in the areas of construction, maintenance, inspection, and recycling & reuse of transport infrastructure. This will be reached by the involvement of all stakeholders (owners, researchers, and industry) of the four transport modes in a phased approach: Starting with the determination of the state-of-the-art in research and practice, in the next step the most promising practices and ideas will be identified. By mapping the common needs, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Knowledge Based Bio-Economy towards 2020 – conference: turning challenges into opportunities' under Seventh Framework.

assistant: **Concept**

The Knowledge Based Bio-Economy  (KBBE) focuses on sustainable management, production and use of renewable biological resources, through life sciences and biotechnology and convergence with other technologies, to address the great societal challenges, to enhance the EU overall competitiveness and to meet high consumer demands.The twofold aim of the KBBE towards 2020-conference is completely in line with the WP 2010’s main objective:1. Taking stock of the progress made since 2005 (launch of KBBE by the European Commission (EC))2. Contributing to the new vision and action plan of the European Commission for a Sustainable Bio-Economy. Although the knowledge base in Europe is outstanding, we have to ensure that Europe keeps this comparative advantage and grows even more competitive and innovative. Therefore the Commission and the Member States need to find a holistic strategy for the bio-economy. This new KBBE-strategy is an integral part of the new EU 2020 Strategy .During the conference, there will be room for interactive discussions with all the involved stakeholders (industry, policy makers, researchers, consumers and civil society organisations) in three parallel sessions each addressing an important aspect of the bio-economy: availability of feedstocks for the bio-economy, innovative biobased products in greening the industry and innovative food production and eco-innovation in the food industry.While organising this conference, we have taken into account the need to focus on socio-economic research, the participation by women and gender aspects, the need for promotion of effective communication and dissemination, as will be shown in part B of this document.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'STRENGTHENING OF RESEARCH CAPACITY FOR POPLAR AND WILLOW MULTIPURPOSE PLANTATION GROWING IN SERBIA' (STREPOW), addressing dissemination and exploitation.

assistant: **Impact**

The objective of the project is to strenghten the capacities of researchers to successfully participate in research activities at EU level,  reinforcement research infrastructure of the Institute of Lowland Forestry and Environment, so that it could become the Center of Excellence in the region of Western Balkan Countries for growing of multi purpose poplar and willow plantations in Serbia, aiming at the production of biomass for energy and the phytoremediation of the contaminated sites by: Sustainable partnership and networking partners from EU countries; sending scientists for short stay in Networking partner institutions to carry out a specific research experiment related to poplar and willow plantations and the production of biomass, and application of these plantations for the phytoremediation of the damaged land and water, and also the preparation of the cooperative activities or joint RTD proposals; hosting the scientist from Networkin partners to organise the training for the researchers of the Institute of Lowland Forestry and Environment; by the improvement of human potential - employment of two young researchers who will direct their activities to the growing of multi-purpose poplar and willow plantations in Serbia; by the acquisition of the laboratory equipment.  The exchange and the dissemination of multiannual research results between the institutions, and especially the transfer by EU Networking partners enables and supports the research capacity reinforcement of the Institute of Lowland Forestry and Environment what will have significant effect on the increase of area and the more efficacious establishment of Short rotation plantation in Western Balkan Countries on the less productive agricultural and contaminated soils.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Aquachallenge: aquaculture challenge-asia: international workshop to discuss strategies to achieve the goals of sustainable aquac-ulture, high-quality environmentally acceptable products, with current technological, scientific and environme' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The 3-day workshop, targeted towards the Asian sector, with 50 invited participants, will address issues of special relevance for aquaculture in the developing countries: the need to the need to make progress towards the goal of sustainable aquaculture, not only to protect the environment and promote ethical issues, but also to ensure the production of quality products of high market value; the need for transfer of know-how in the optimisation of feed management strategies; brood stock management, not only for good egg and larval quality , but also to preserve genetic diversity; the need to highlight contrasts and similarities between different geographic areas; the need to develop marketing and distribution infrastructure. Discussions and knowledge sharing of such matters will lead to the formulation of practicable strategies as a potential basis for agreements concerning sustainable aquaculture in the context of environmental protection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Identification of transcriptional memory maintenance factors through a cell selection strategy'.

assistant: **Objectives**

Memory of gene expression states is essential for development and maintenance of tissues. Chromatin, a protein DNA complex, is implicated in the process. Local, chromatin feedback loops are involved in maintenance of gene silencing, but analogous mechanisms for preservation of active states are unknown. In order to reveal feedback loops for active gene expression states it is crucial to uncouple them from ongoing transcription, as it occurs in the case of maintenance of silent states. Such partition takes place during trained immunity – memory of the innate immune system. A key paradigm is interferon gamma (IFNγ) stimulation. While IFNγ induces many genes, a subset of those is maintained in a poised, inactive state that allows for rapid re-activation at a later time – an event called transcriptional memory.In my ongoing research I have discovered novel genes that show strong transcriptional memory of prior IFNγ activation and have obtained initial mechanistic insights into the role of chromatin in the process. Importantly, I discovered that memory results in a larger proportion of cells expressing the target gene. This forms the basis of a cell sorting, high throughput assay that I have developed. I am now in a unique position to capitalize on those discoveries and tools. I aim to identify novel transcriptional memory maintenance factors in human cells using an unbiased approach based on an efficient cell selection strategy combined with genome wide, CRISPR-Cas9 mutagenesis protocols. Secondly I wish to establish the function of the identified components in the stability of dendritic cells identity after differentiation form monocytes.The multidisciplinary and unique perspective of this project: combining gene expression analysis and selection strategies with immunologi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cancer Cellular Metabolism across Space and Time' to be submitted under Horizon 2020.

assistant: **Abstract**

The metabolism of cancer cells is altered to meet cellular requirements for growth, providing novel means to selectively target tumorigenesis. While extensively studied, our current view of cancer cellular metabolism is fundamentally limited by lack of information on variability in metabolic activity between distinct subcellular compartments and cells.We propose to develop a spatio-temporal fluxomics approach for quantifying metabolic fluxes in the cytoplasm vs. mitochondria as well as their cell-cycle dynamics, combining mass-spectrometry based isotope tracing with cell synchronization, rapid cellular fractionation, and computational metabolic network modelling.Spatio-temporal fluxomics will be used to revisit and challenge our current understanding of central metabolism and its induced adaptation to oncogenic events – an important endeavour considering that mitochondrial bioenergetics and biosynthesis are required for tumorigenesis and accumulating evidences for metabolic alterations throughout the cell-cycle. Our preliminary results show intriguing oscillations between oxidative and reductive TCA cycle flux throughout the cell-cycle. We will explore the extent to which cells adapt their metabolism to fulfil the changing energetic and anabolic demands throughout the cell-cycle, how metabolic oscillations are regulated, and their benefit to cells in terms of thermodynamic efficiency. Spatial flux analysis will be instrumental for investigating glutaminolysis - a ‘hallmark’ metabolic adaptation in cancer involving shuttling of metabolic intermediates and cofactors between mitochondria and cytoplasm. On a clinical front, our spatio-temporal fluxomics analysis will enable to disentangle oncogene-induced flux alterations, having an important tumorigenic role, from artefact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Distortions of Normativity: The NS-System and Morality'.

assistant: **Concept**

The Nazi system was not amoralism in the classical textbook sense but a specific, though contorted normative order. The basic argument was that political emergency conditions made it necessary to replace the unstable liberal-democratic framework of the Weimar Republic by a 'new source of law : the authority and political will of the Führer. The claim to correctly interpret the Führer s will and intentions became the new foundation of legitimate political action . Consequently emergency decrees, political initiatives, and party agitation replaced the rule of law. The Nazis worked, however, with a highly moralized conception of social reality, based on perverted notions of duty, honor, loyalty, fidelity, and sincerity. The Nazi regime provided people with justifications of policies and measures that for many followers amounted to a 'meaningful story . They managed to set a normative framework within which even fulfilling killing orders 'made sense . A perverted model of practical reasoning was propagated by the highest authorities according to which immediate reactions of resistance and revulsion counted as 'natural temptations' which had to be overcome. The aim of the project is to: - provide a detailed account of the normative order of the Nazi system and the transformations of the key political and legal institutions that it brought about; - analyze in detail the distorted notions of duty, obedience, and decency and the corresponding self-conceptions the Nazi regime encouraged; - explore the implications of our findings for the following broader questions: * How should we assess conceptions of normativity under non-ideal conditions? * What is the relationship between legality and legitimacy under non-ideal conditions? * What exactly are the standards for acting morally