RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'A New Perspective on City Logistics: Concepts, Theory, and Models for Designing and Managing Logistics as a Service'.

assistant: **Objectives**

Several social, economic, and technological trends are coming together to revolutionize the way people, products, and services are brought together. Goods are gaining more mobility with drastic implications for cities. The current city logistics (CL) paradigm, which does not consider the mobility of goods a public need, limits our capacity to understand and respond to the challenges and opportunities brought by this profound change. Taking a different perspective, GoodMobility proposes to replace the techno-business-centric smart thinking with network-centric wise logistics that takes the public value as the primary goal and envisions setting up a logistics web with the required infrastructure (hardware) and operating procedures (software) to establish logistics as a service (LaaS). The first objective is to develop public value as a measurement system to assess and guide CL planning and management, which will be achieved with an iterative process, combining multi-criteria decision making, sustainability analysis, simulation, and optimization. The second objective is to develop the principles, models, and tools for LaaS infrastructure design. Novel network optimization methods will be developed for designing the hardware of LaaS to provide orders of magnitude efficiency gains and influence the stakeholder activities to maximize public value. The third objective is to develop a theoretical framework and models for the operating procedures of LaaS, introducing the logistics markets to ensure efficiency and reliability and secure public value in matching logistics demand and supply. Learning-based optimization methods will be developed to manage logistics markets. If successful, GoodMobility will lay the foundations of a new theory of CL with significant scientific and pra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Exploring the Borderline of bonding in Group IV Nitroso Compounds by Gas Phase Electron Diffraction (GED)' (GED) targeting Seventh Framework.

assistant: **Abstract**

The aim of this project is the synthesis and structural characterization of nitroso derivatives of the heavier group IV elements, R3E-NO (E = Si, Ge, Sn). The substituents R are varied in size, electronegativity and molecular hardness in order to study these effects on the bonding situation around the central atom. Besides the synthesis a major part of the project should involve the structural characterization by gas phase electron diffraction, which seems to be the method of choice for this new class of molecules. However, it is also intended to explore the further chemistry of these compounds. In particular, reactions with compounds bearing Pi-systems like alkenes, disilenes, iminosilanes etc. seem to be promising regarding the build-up of new (ring) systems. After isolation and structural characterization of the nitroso compounds, CVD related applications will be the focus of the work. Especially the synthesis of new Si-N-O and Si-O-N-C based materials seems to be an exciting topic of research. Nevertheless, even for CVD related processes the knowledge about the gas-phase structure of nitroso compounds is essential for a prediction of the properties of the synthesized materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Leading the first data revolution in European agriculture: farm accountancy data and their impact 1870-1945' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Long before Big Data invaded the countryside with datafication and High Precision Farming in the 2010s, at least another data-revolution had taken place in Europe. The spread of bookkeeping to ordinary farmers that started in the second half of the 19th century represents a revolutionary phenomenon whose importance and magnitude have been underestimated by historians. After overseas competition hit European farmers in the 1870s, the diffusion of bookkeeping techniques among ordinary European farmers was an important component of the recovery. The farm accountancy offices that mushroomed in northern and central Europe thanks to the work of economists and agricultural unions were crucial to reach medium and small farmers. Such offices acted as consulting agencies to farmers, helping them to be more efficient. But the offices also aggregated farm accountancy data from individual farms to produce benchmarks and for statistical purposes. Farmers unions could thus use micro-data to enlighten macro-economic issues and guide policy decisions at different levels in a striking example of “stakeholders’ statistics.” DATAREV investigates the diffusion of farm accountancy offices of continental Europe since the 1870s and the use of farm accountancy data by state and non-state actors in the first half of the 20th century. With its four subprojects, DATAREV thoroughly explores different aspect of the first data revolution, its actors and its consequences. It examines how economic and socially change was conceptualized and direct through accountancy data and statistics and how the peculiar structure of the agricultural business in Europe imposed constraints on bookkeeping unlike those at work in industry. It questions the agency in the datafication process and explores the conflicting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The unique dioxygenases of phytophagous spider mites: new enzyme players in plant-herbivore interactions?'.

assistant: **Objectives**

Detoxification of poisonous xenobiotics in animals is typically performed by multi-gene enzyme families. Within arthropods, only insect genomes have been studied in detail where these families are well characterized. I recently uncovered a new enzyme family in the genome of a non-insect arthropod, the extremely polyphagous plant-feeding mite Tetranychus urticae and showed that this proliferated family was acquired via horizontal gene transfer from a fungal donor. The family codes for intradiol ring cleaving dioxygenases which cleave a particular set of aromatic structures, commonly found in pesticides and plant metabolites. Here, I propose to functionally characterize this exciting new gene family and to elucidate its role in xenobiotic detoxification, with a focus on plant secondary metabolites. First, to create a general picture, I will map the in situ expression of dioxygenases and time their responses to plant-derived secondary defense metabolites. Second, guided by preliminary results, I plan to study how these new herbivore enzymes counteract polyphenol oxidases, well-known plant defense enzymes that act against herbivores and target the same class of substrates. State-of-the-art plant transformation experiments will be performed in order to meticulously dissect their counterplay. Finally, by means of an unbiased multi-layered strategy, I will functionally characterize these new dioxygenases. Dioxygenases will be introduced into biological systems by functional expression in E. coli or insect cells, and by genetically transforming Drosophila. Cutting-edge differential metabolomics will identify the substrates and reaction products. By means of this project, I expect to unravel the selective advantage of this new family for phytophagous mites and open up avenues to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Expectational Visual Artificial Intelligence' (EVA), addressing dissemination and exploitation.

assistant: **Impact**

Visual artificial intelligence automatically interprets what happens in visual data like videos. Today’s research strives with queries like: “Is this person playing basketball?”; “Find the location of the brain stroke”; or “Track the glacier fractures in satellite footage”. All these queries are about visual observations already taken place. Today’s algorithms focus on explaining past visual observations. Naturally, not all queries are about the past: “Will this person draw something in or out of their pocket?”; “Where will the tumour be in 5 seconds given breathing patterns and moving organs?”; or “How will the glacier fracture given the current motion and melting patterns?”. For these queries and all others, the next generation of visual algorithms must expect what happens next given past visual observations. Visual artificial intelligence must also be able to prevent before the fact, rather than explain only after it. I propose an ambitious 5-year project to design algorithms that learn to expect the possible futures from visual sequences.The main challenge for expecting possible futures is having visual algorithms that learn temporality in visual sequences. Today’s algorithms cannot do this convincingly. First, they are time-deterministic and ignore uncertainty, part of any expected future. I propose time-stochastic visual algorithms. Second, today’s algorithms are time-extrinsic and treat time as an external input or output variable. I propose time-intrinsic visual algorithms that integrate time within their latent representations. Third, visual algorithms must account for all innumerable spatiotemporal dynamics, despite their finite nature. I propose time-geometric visual algorithms that constrain temporal latent spaces to known geometries. EVA addresses fundament
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'ELECTRONIC PUBLIC PROCUREMENT SYSTEM FOR EUROPE'.

assistant: **Innovation**

ELPRO will demonstrate how regional telematics-based networks can enhance business procurement activity. The project will support small and medium-sized enterprises (SMEs) and other suppliers. In addition it will add and public and private sector authorities (including the European Commission) which initiate procurement. Developed in close conjuction with TAPPE (project AD 1015), ELPRO will enable these parties to benefit from a single integrated service based on currently existing networks. It will also explore the technologies to be used by SMEs following consultation with information brokers and other service providers.ELPRO addresses the needs of three overlapping user groups- Administrations (including both the European Commission and Member states)- Procuring entities (in the public, utilities, and private sectors)- suppliers and potential suppliers (in particular small and medium sized enterprises [SME] and publishers)ELPRO as a European electronic public procurement system will build and demonstrate on a number of sites (including a virtual procurement region") regional procurement information partnership and business information networks targeted at SMEs using the complete range of free and paid-for Telematics services, from fax-on-demand services, electronic data interchange (EDI/EDIFACT), and Internet services to illustrate the means of establishing SME support networks on any Telematics environment in Europe. ELPRO will provide a unique integrated service which will enable procuring entities to generate optimal Telematics support services for local SMEs at the same time as capturing the efficiency benefits of electronic procurement for themselves.ELPRO will make full use of the current technology as a basis for further development and validation, basing the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development and validation of the first digital, clinical grade flow cytometry platform for enhanced diagnosis accuracy and sustainability in immunology and hemato oncology' in the context of a Horizon Europe call.

assistant: **Objectives**

After successful development of METAglut1, an IVD Medical Device for diagnosis of the Glut1 Deficiency Syndrome ( available for clinical use), we are currently focused on developing a new breakthrough solution: METAflow. Flow cytometry (FC) is a powerful tool widely use in research. However, the high cost and complexity of interpretation of FC data hampers its full clinical exploitation. Main pain-points of clinical FC data analysis, include need for manual analysis, which is accompanied by complexity with increasing number of dimensions, lack of robustness and limited scale-up. The lack of automated analytical process stems from dearth of robust algorithms, limited regulatory compliance and need for considerable coding skills. With METAflow we bring to the market the first digital, clinical grade FC platform, which offers comprehensive data analysis, robustness, and usability, addressing the lost in translational research issue of flow cytometry in the clinics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Multilingual Transmission in Indigenous Languages in the Diaspora'.

assistant: **Objectives**

Bilingual speakers of a Heritage Language (HL)—a language acquired naturalistically from early childhood, but distinct from the dominant language of the larger society—often display innovation and variation. Which exact factors account for this observation is subject of both theoretical discussion and empirical work. Cross linguistic influence (CLI) from the majority language plays an important role. However, the providers of input for the HSs are bilinguals living in the same dominant language society and potentially themselves HSs, whose linguistic patterns can be qualitatively different from those of the speakers from the homeland. To address the genuine contribution of the CLI in HL development, a good and largely underused comparison within the study of HLs would be the tripartite comparison of (i) HSs, (ii) their L1 immigrant input providers and (iii) speakers in the homeland. Most of psycholinguistics, including HL, research is conducted on languages endowed with writing systems and literacy traditions, an official status in some areas of their spread and a large, multi-million speaker population. Thus, what we know about HLs is largely based on a small sample of language pairs in a handful of sociolinguistic situation types. This incompleteness of coverage underdetermines the power of generalizations from empirical observations as well as their contributions to (psycho)linguistic theories. Therefore, it is urgent to take psycholinguistic studies out of the lab and focus on lesser-studied, including indigenous HLs. Using Mano as a case study, the objective of MuTILDa (Multilingual Transmission in Indigenous Languages in the Diaspora) is to study variation in linguistic knowledge of speakers of an indigenous HL in the diaspora, measured at the level of production
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'An Ultra-sensitive Assay to Measure Oligomer Induced Toxicity in Human Cerebrospinal Fluid' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The study of protein aggregates and how they damage neuronal cells is important in order to understand the initiation and progression of several neurodegenerative diseases - including Alzheimer’s disease (AD), Parkinson’s disease (PD). The aggregation from the native monomeric proteins to beta sheet containing amyloid structures involves the formation of different species - misfolded proteins, small soluble oligomers and finally formation of fibrils. It is believed that small oligomers are the most cytotoxic species which play a major role in neuronal loss and cell death. Although, the exact mechanism and extent of amyloid oligomer’s cytotoxicity is still unknown, one of the most consistent pathologies in neurodegenerative disease is unregulated influx of Ca2+ into the cell. Individual oligomers directly disrupt cell membranes through non-specific binding at picomolar concentrations leading to the formation of ion channels, which allow Ca2+ influx and can lead to cell death. Based on this observation, we will develop a single liposome assay to quantify the oligomer induced toxicity from oligomers present in human cerebrospinal fluid (CSF) from healthy controls and patients with AD and PD. Using a Ca2+ sensitive fluorogenic sensor, we will monitor the oligomer induced Ca2+ influx inside the liposome in real time. We will measure and compare the toxicity of synthetic oligomers of amyloid beta, alpha-synuclein, tau and PrP oligomers as a function of oligomer concentration and liposome membrane composition. We will then quantify the effect of various antibodies commonly used for treatment of AD and PD on the toxicity of synthetic oligomers and those in CSF. This novel ultra-sensitive state-of-the-art single molecule technique will provide new insights into the mechanism of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Structural studies of the eukaryotic ribosome by X-ray crystallography' (2007-2013).

assistant: **Concept**

The ribosome is a large cellular organelle that plays a central role in the process of protein synthesis in all organisms. Currently, structural information at atomic resolution exists only for bacterial ribosomes and some of their functional complexes. Eukaryotic ribosomes are larger and significantly more complex than their bacterial counterparts. They consist of two unequal subunits with a combined molecular weight of approximately 4 million Daltons and contain 70-80 different protein molecules and four different RNAs. Currently the only structural information on eukaryotic ribosomes is available from cryo electron microscopic reconstructions in the nanometer resolution range, which is insufficient to derive information about the function of the eukaryotic ribosome at the atomic level. The aim of this proposal is to use X-ray crystallography to obtain structural and functional information on the eukaryotic ribosome and its functional complexes at high resolution. The key targets of the structural work will be: i) the structure of the small ribosomal subunit, ii) the structure of the large ribosomal subunit, and iii) structures of complexes involved in the initiation of protein synthesis. Besides the obvious fundamental importance of this research for understanding protein synthesis in eukaryotes the proposed studies will also be the prerequisite for understanding the structural basis of the regulation of protein synthesis in normal cells and how it is perturbed in various diseases. Finally, comparing the structures of bacterial and eukaryotic ribosomes is important for understanding the specificity of various clinically used antibiotics for the bacterial ribosome.