RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'OncoTrack - Methods for systematic next generation oncology biomarker development' (ONCOTRACK) targeting Seventh Framework.

assistant: **Abstract**

We propose here an exhaustive analysis of the genome, exome, methylome and transcriptome of primary tumours and metastases from patients with colon carcinoma, based on a combination of deep sequencing and chip based techniques. Dependent on their availability, we shall also perform analyses of tumor stem cells, circulating tumor cells, free tumor DNA in serum and xenografts derived from the same patients. This will be complemented by the development and application of highly sensitive techniques to identify individual mutations, transcripts and proteins/protein complexes both in-situ in pathology slides as well as in patients’ blood or serum. The integration of these results will allow us to address the heterogeneity of the tumor samples, to deduce the genome/epigenome/transcriptome of the different cell types making up or originating from the tumor (e.g. circulating tumor cells, tumour stem cells or xenografts), to establish models able to predict suitable candidates for further biomarker development, and also to predict the effects and side effects of drugs in the treatment of genetically defined groups of patients. Available biomarkers, as well as biomarkers predicted from the work within the project will be validated in patient derived xenograft models and stem cell cultures, and ultimately transferred into a point of care (POC) diagnostic format. In parallel we will explore the use of the global genome and methylome information, e.g. derived from the analysis of free tumor DNA in the serum of the patient, as the ‘ultimate’ biomarker, to model the biology of the tumor (possibly even before any tumor has been localised), and as an independent route to predict clinically relevant parameters. Though sequencing/methylation analysis of the genome of the tumor through fre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Archiving and Preservation for Research Environments' (ARCHIVER), addressing dissemination and exploitation.

assistant: **Impact**

Data has both a value and a cost and modern research data management makes many promises in terms of capacity, scalability, ease-of-use and security. The stewardship ofresearch data involves not only all data-related tasks during the active lifetime of a project itself but also preparing the data and associated information for later re-use.The period during which research data remains valuable can stretch into decades.Currently, many research projects cannot manage their data, as the archiving and preservation services are inadequate and fall below expectations while data stewardship costs are frequently underestimated during the planning phase.Using the PCP instrument and building on results of recent projects, ARCHIVER’s goal is to fulfil these data management promises in a multi-disciplinary environment, allowing each research group to retain ownership of their data whilst leveraging best practices, standards and economies of scale.ARCHIVER will combine multiple ICT technologies, including extreme data-scaling, network connectivity, service inter-operability and business models, in a hybrid cloud environment to deliver end-to-end archival and preservation services that cover the full research lifecycle.The use-cases driving the consortium’s need for research and development of innovative data preservation services will extend the preservation ecosystems of the procurers to create more dynamic solutions using a hybrid model combining on-premise capacity with external services operated by commercial suppliers that will be enhanced to comply with the OAIS (ISO 14721) series of standards.One of the main benefits of such a hybrid approach is that it can be implemented in a way that is transparent to data producers and (re-)users. This transparency will address issues that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structural and functional analysis of two clock proteins in diptera' to be submitted under Fourth Framework.

assistant: **Abstract**

Circadian 24 hrs patterns of behaviour and physiology are ubiquitous in animals and plants, from bacteria to humans. Recent analyses of the molecules involved in biological rhythmicity in the fly Drosophila melanogaster and in the bread mould Neurospora crassa reveal that the key timing molecules seem to act in similar ways, suggesting that solving the problem of biological timing for one organism will serve to unravel a common molecular mechanism for all organisms. In Drosophila melanogaster, where the greatest advances have been made, two proteins PERIOD (PER) and TIMELESS (TIM), interact to generate circadian rhythmicity. They are both negative regulators of the* own transcription and they dimerise in the cytoplasm before entering the nucleus. The binding domain of PER involves a 280 amino acid region termed PAS, whereas the corresponding domain for TIM includes about 400 amino acids. Mutations which disrupt this association produce dramatic changes in periodicity. However, other than a general appreciation of the relevant dimerization domains of the two proteins, almost nothing is known about how timing information is transmitted from the cytoplasm to the nucleus. The per gene evolves relatively quickly, and evidence from two of our laboratories suggests that the PER-TIM interaction may co-evolve, so that PER from one Dipteran species does not dimerise well to TIM from another. A comparative structure/ function approach will be used where we will initially examine the relevant sequences from the per and tim genes in a variety of Dipteran species and study their homo and heterospecific binding abilities using a yeast assay which tests for protein-protein interactions. We will simultaneously determine the molecular 'shapes' of the PER and TIM interacting surfaces in D
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Gender Dynamics and Quotas: Unlocking the Potential of Political and Economic Empowerment' (GAPP), addressing dissemination and exploitation.

assistant: **Impact**

Achieving gender equality in politics, the labour market, and public life is essential for fostering a fair and inclusive society. This project explores the effectiveness of key policy tools aimed at closing gender gaps across Europe. The first part of the study examines the impact of gender quotas - both hard quotas like parity laws and soft quotas like voluntary party commitments - on women’s representation in the European Parliament, drawing on data from the 2024 EU elections. Additionally, it analyses growing gender-based disparities in trust and perceptions of public institutions. The second part of the project evaluates the role of female politicians in shaping gender equality policies, with a specific focus on Denmark’s recently introduced earmarked parental leave reform. Through innovative quasi-experimental research methods and text analysis, the project will assess both political discourse and policy outcomes, providing valuable insights into how gender equality initiatives impact public life and governance across Europe. Ultimately, this research will contribute to a deeper understanding of the demand for and effectiveness of gender equality policies, as well as their broader social and political implications.


**Keywords:** Policy evaluation; Gender quotas; Trust in institutions; Survey design
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'virtuOus futuRes: Alternative aCcounts for desirabLe dEmocratic Societies'.

assistant: **Innovation**

The challenge of ORACLES is to understand how the combination of accounting practices and artistic approaches can assist in the creation of virtuous futures for democratic societies. Rising challenges such as social inequalities, and conflicts are increasingly forcing public organisations to imagine different, desirable, inclusive futures. At the same time, though, democratic institutions are facing constituencies’ growing disinterest in general democratic life, leading to declining trust, and growing dissatisfaction with public accountability processes. ORACLES seeks to investigate alternative approaches to reform such processes, embedding creativity and morality into accounting, and transforming it from an oracle providing deceivingly safe answers, to a tool for civically engaged, democratic futures. The project will provide an analysis of how alternative, art-based accounts can be constructed and inspire social transformation, focusing on artistic productions such as Science Fiction (SF) as complementary to traditional accounting storytelling and practices. It will then move into specific dynamics of accountability in organisational processes, investigating how an alternative future is constructed within an arts-centred project in Palermo, Italy. Finally, it will develop a new framework to use accounting and reporting as a tool for the common good, harnessing insights from artistic approaches and moral theory. Results will be translated into actionable insights for EU communities and policymakers involved in the construction of better futures through the production of a dedicated policy brief, harnessing insights from the project scientific articles, and ensuring the knowledge transfer to both policymakers, and constituencies. Thus, ORACLES will generate contribution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'INNOVATIVE DRYING IN TISSUE PAPER MILL USING DIRECT EXHAUST GASES FROM A TURBINE' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Fully integrated electrical and thermal energy production plant in a tissue paper mill. Natural gas fired gas turbine 13 MWe with an exhaust gas boiler will furnish all of the electricity, steam and drying air for the process. Purchase of electricity and use of heavy fuel oil for steam and propane for drying air will be replaced. For the first time in EU all these energy needs will be fully integrated. True cogeneration. Appreciable reduction of CO2, CO, NOx, SO2 and particles. Annual production 47 000 tons of tissue paper on two machines. Steam to Yankee cylinder and heat to the hood, drying the paper, innovative.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Exploring the roles and plasticity of T-cell responses in anti-BACterial immunity' (T-BAC) under Seventh Framework.

assistant: **Objectives**

Antibodies against bacterial polysaccharides and proteins play a role in anti-bacterial immunity. To date, S. aureus vaccine candidates were selected to induce functional antibody responses. However, a potential role for T-cell mediated immunity is emerging, supported by the fact that impaired Th17 responses in patients with hyper IgE syndrome are linked to abnormal susceptibility to S. aureus infections. Thus, the capacity to induce specific T cell responses may be an important criterion to select vaccine antigens. Understanding the nature of anti-bacterial T cells and their behavior in steady state or under inflammatory conditions (eg, immunization) is thus important for the design of novel vaccine strategies against bacterial pathogens. Among CD4 T cells, Th17 cells play a pivotal role in mucosal host protection. These cells are mainly characterized by the production of the cytokine IL 17A but display considerable phenotypic plasticity. For S. aureus-specific Th17 cells, published data suggest a link between Th17 plasticity and the innate cytokine IL-1b, highlighting the need to better understand the functional role of the different Th17 subsets. Using S. aureus as a model, and hypothesizing that the functional profiles of CD4 T cells (Th1, Th17) may be linked to selected bacterial proteins, we first aim to identify specific S. aureus antigens with defined Th profiles in humans. Second, using in vitro stimulation methods, we aim to phenotypically characterize S. aureus-specific CD4 T cell responses induced by these proteins. Phenotypic plasticity and behavior will be studied under inflammatory (IL-1b, IL-6 or IL-23) cell culture conditions. Third, we aim to evaluate the impact of vaccination on the frequency, phenotype and plasticity of specific memory CD4 T cells, u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Let the music move you: involvement of motor networks of the brain in music processing' (MusicMoves) under Seventh Framework.

assistant: **Objectives**

Previous work has shown an intricate connection between music processing and movement in the brain. This overlap is also present for imagined music, and may as such be applied to existing imagery-based movement rehabilitation paradigms. In the following proposal we outline two main questions. The first concerns the extent of the involvement of motor areas during music processing in various modes, namely perception, auditory imagination, auditory-motor imagination and observation. Common and separate brain activation patterns will be assessed using fMRI. The second question addresses the effects of imagery training paradigms on plastic changes in the brain, and the effect of cuing during this training. Pre- and post training fMRI will be measured as well as the behavioral output of the training. These questions will address unanswered issues that are relevant to existing movement rehabilitation paradigms. Additional to furthering our knowledge of imagery mechanisms in the brain, the results will be directly applicable to the clinical arena, as well as training in high-level skill acquisition.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Uncovering the pathway of DNA-induced autophagy and its biological functions in viral central nervous system infection' (PathAutoBIO), addressing dissemination and exploitation.

assistant: **Impact**

Pathogens establish a range of strategies to efficiently infect and persist in their hosts. These mechanisms are as varied as pathogens themselves, which poses many difficulties for fighting infections. A deep understanding of host defense mechanisms is thus crucial for developing innovative therapies. Sensing of pathogen-derived nucleic acids is pivotal for induction of host defense. The adaptor molecule STING plays a central role in this defense and coordinate activation of immune responses. Recent studies showed that cytosolic DNA sensing and subsequent STING activation also leads to induction of autophagy, a degradative pathway involved in metabolic recycling and regulation of infections and immunity. Both STING and autophagy are involved in a range of diseases e.g. infectious and autoimmune diseases, neurodegeneration and cancers. However, the links between STING and autophagy and their regulation of the balance between protective responses and harmful inflammation is elusive. Likewise, the roles of STING-mediated autophagy during viral infections is unknown. Using cutting-edge tools e.g. ImageStream X flow cytometry and genome-editing of human stem cells-derived brain cells using CRISPR/Cas9, PathAutoBIO will decipher the pathway of this novel STING function. We will then combine in vitro and in vivo models of central nervous system viral infection to explore STING-mediated autophagy functions at this unique site, where autophagy and STING are important for viral clearance. We will build upon the expertise of the host lab in DNA sensing, take advantage of unique tools developed for the project, and integrate leading international collaborators. Combined with my strong background in infection cell biology, our work will provide insights on the cross-regulations bet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Parliaments and Civil Society in Technology Assessment' (PACITA), addressing dissemination and exploitation.

assistant: **Impact**

The PACITA Mobilisation and Mutual Learning Action Plan will distribute capacity and enhance the institutional foundation for knowledge-based policy-making on issues involving science, technology and innovation, mainly based upon the practices in Parliamentary Technology Assessment (PTA). PTA supports the processes of democratic policy-making on issues involving science, technology and innovation, by providing comprehensive insight into knowledge on opportunities and consequences, by facilitating democratic processes of debate and clarification, and by formulating policy options.PACITA will a) document these practices, b) describe schemes for using them nationally and at European level, c) establish a set of training schemes for users and practitioners, d) establish a Web Portal to European TA expertise e) create a debate on such practices in countries, which do not have them formally established, f) involve experts, societal actors and politicians in European debates on these practices, g) provide three large example-projects on expert-based praxis, stakeholder involvement and citizen consultation, h) support this with a strong dissemination strategy towards the policy-makers, the scientific community, media and countries, which can favor from the mobilization and mutual learning created by the Action Plan, and i) have an independent evaluator monitor the progress and results.The consortium has 15 partners from: National/regional parliamentary offices for science and technology; Science academies; Research institutions; Universities; Civil Society Organisations. The Coordinator is a PTA institution, highly experienced in project managing, which has taken part in more than 10 EU projects including an ERA-Net, and has coordinated two FP projects and a global citizen cons
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Graphene-based Nanoelectronic Devices' (GRAND) under Seventh Framework.

assistant: **Objectives**

The semiconductor industry is a cornerstone of today's high-tech economy, supporting over 100,000 direct and even more indirect jobs in Europe. This position has been achieved through continued miniaturization in complementary metal-oxide-semiconductor (CMOS) technology, which will only last for a maximum 10-15 more years. In line with its Lisbon Strategy, the EC has identified an urgent need to assess possible technology solutions for the Beyond CMOS" era to meet the challenges of global competition.<br/><br/>The major ICT challenge is to find alternatives for information processing and storage beyond the limits of existing CMOS. Graphene, ultrathin layers of carbon, is particularly promising due its novel electronic properties. Initial data indicates that graphene is a prime candidate for "Beyond CMOS" switches and interconnects, and is, despite its revolutionary nature, complementary to conventional CMOS.<br/><br/>The key objective of the GRAND proposal is to verify and assess whether graphene can bring conventional semiconductor technology to the "Beyond CMOS" era. GRAND is thus positioned to act as a pathfinder for key ICT challenges.<br/><br/>The GRAND consortium will develop industry-compatible strategies for fabrication of 2D graphene nanostructures (widths down to the 5 nm scale) for switches and interconnects. Edge states, critical for transport at this scale, will be manipulated by functionalization methods. Device transport properties will be experimentally evaluated, complemented by a range of modelling techniques including simplified Monte Carlo models to describe scattering and hot phonon effects, as well as atomistic and ab-initio methods for band structure calculations. <br/><br/>The consortium includes internationally renowned experimental and theoreti