RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Peptide-based Nanoparticles as Ocular Drug Delivery Vehicles' (PANOPTES) under Seventh Framework.

assistant: **Objectives**

This project will develop methodology for the manufacture of novel peptide-based nanoparticles and nanocapsules to satisfy an unmet clinical need: sustained drug delivery to the posterior segment of the eye. The proposed consortium brings together internationally leading groups in self-assembling polypeptide nanoparticle and nanocapsule preparation by chemical (Durham) and genetic (Nijmegen) approaches, drug loading and in vitro release studies (Helsinki & Madrid), in vitro and in vivo assessment of nanoparticle biocompatibility and functionality (Helsinki, Madrid & Tübingen) and polymer synthesis, processing and industrial validation of manufacturing processes (DSM). Polyester micro- and nanoparticles that have been proposed for ocular drug delivery have several major drawbacks: acidic degradation products cause inflammation; drug release is difficult to control; and peptides and proteins are difficult to encapsulate. A platform of novel, peptide-based nanomaterials, formed through bio-inspired self-assembly processes, will be developed to overcome these problems. Peptide-based materials have a number of attractive features: biodegradation gives non-inflammatory products; self-assembly occurs under mild conditions; they possess a rich chemical diversity; they are defined at the sequence level. Polypeptides and peptide hybrid materials will be processed into nanoparticles, polymeric vesicles (polymersomes) and nanocapsules. These biodegradable and biocompatible materials will be used as containers for the loading, controlled release and cellular delivery of therapeutic molecules. The consortium therefore will enable the industrial manufacture of as-yet unobtainable, high value nanotechnology-based products utilising intrinisically low-energy demand nanobiotechnological
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Island satellite observation for local exploitation.'.

assistant: **Concept**

The ISOLE Project is aimed at supporting the local administrations of small/medium size Mediterranean islands in the decision making associated with their daily coastal management tasks. In particular the Project is focused on the quantitative assessment of the mutual impacts between human pressure led by seasonal tourism and the status and evolution of marine and coastal land resources. ISOLE information shall be generated by a set of applications, based on satellite remote sensed data and integrating locally collected information, harmonised within a pre-operational environment that will enable quality and benefits evaluation by target end-users within two pilot cases, the island of Elba (IT) and Mykonos (GR). The local administrations of the two islands actively participate within the Project as Partners. The ISOLE Project has a scheduled duration of 2 years, including an operational period of 3 months. The Project includes the specification, design, implementation and transit to operations of the following main elements: 1 ) A set of satellite based applications in the following areas:  - Marine Pollution Monitoring;  - Macroscopic Events Detection;  - Coastal Land Resources Monitoring; 2) Local Circulation Models, based on in-situ measurements complemented with satellite data for the: - Short Term Propagation of macroscopic pollutant events distribution; - Long Term Propagation of human induced marine pollution monitoringparameters distribution. 3) A Tourism Analysis and Modelling Application, based on local data and statistics, for the organization and analysis of tourism data and information. 4) A set of Adaptive Tourism Impact Assessment Correlation Models, based on ISOLE application outcomes and tourism data, for the establishment of functional relationships be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Natural antidiabetic & anti-hypertensive drugs'.

assistant: **Concept**

Hypertension and its complications appear to be increasingly common in Egypt. The overall estimated prevalence of hypertension in Egypt was 26.3%. Hypertension prevalence increased progressively with age. Overall, 37.5% of hypertensive individuals were aware that they had high blood pressure, 23.9% were being treated with antihypertensive medications, and only 8.0% were under control. These results indicate that the rates of hypertension awareness, treatment, and control are relatively low.  Diabetes mellitus (DM) is a complex metabolic disorder that increases tremendously all over the world. Diabetes and its complications impose significant economic consequences on individuals, families, health systems and countries. Many medicinal plants have been used to treat (DM) and hypertension since the ancient times as reported in the Ebers papyrus in Egypt. Phytotherapy is not yet included in the evidence-based medicine, especially with respect to DM  and hypertension therapies. Studies of potential anti-diabetic and antihypertensive plants will definitely confer scientific and systematic approach for the use of these plants as hypoglycaemic and hypotensives agents. Solanum fruits and Egyptian dates have been used since ancient times as antihypertensive and antidiabetic in African folk medicine.  Although, little is known so far about the active constituents and mechanism of action of Solanum fruits, its long use in African folk medicine and the fact that it belongs to everyday food in several countries, encouraged us to subject this obviously safe plant to detailed scientific research, in order to produce a safe and effective anti-hypertensive preparation. The project aims to define the most active fraction of the 2 plants extracts and determine their mechanism of action as a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Transferability of pension entitlements (TRAPEN)' (TRAPEN) targeting Fifth Framework.

assistant: **Abstract**

This project will focus on an aspect of public policy that is not in the spotlight of the PAYG versus fully-funded (state) pension debate but concerns an equally important question: the scope for improving job mobility and locative efficiency by eliminating obstacles to the transferability of pension rights. An exploratory workshop will be organised with the specific purpose of arranging a confrontation between researchers and representatives of pension funds, PAYG pension schemes, economists, lawyers, pension benefit experts and other experts working in close connection with pension institutions. This workshop will take stock of the research already accomplished on the influence of pension schemes on labour mobility and on the state of follow up to the 1998 Directive on pensions portability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ATHENA' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The ATHENA project brings together major user communities with world leading experts in crisis management and  experts and technology developers of mobile and social media use and development. The goal of the ATHENA project is to deliver two major outputs that will enable and encourage users of new media to contribute to the security of citizens in crisis situations and for search and rescue actions:• First, a set of best practice guidelines for LEAs, police, first responders and citizens for the use of new media, supporting tools and technologies in crisis situations• Second, a suite of prototype software tools to enhance the ability of LEAs, police, first responders and citizens in their use of mobile and smart devices in crisis situationsThis project will explore how the huge popularity of new communication media, particularly web-based social media such as Twitter and Facebook, and the prolific use of high-tech mobile devices, can be harnessed to provide efficient and effective communication and enhanced situational awareness during a crisis.The ATHENA system is a crisis communication and management system that encourages and enables the public to participate, in an ethical way, in the process of emergency communication to contribute to the security of the citizen in crisis situations and for search and rescue actions. ATHENA makes use of new social media and high tech mobile devices to efficiently and effectively acquire, analyse and disseminate crisis information and intelligence that is appropriate and useful to LEAs/police/first responders and the public.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Timing of bird migration under climate change: phenotypic plasticity, microevolutionary response or both?' (BIRDCLIMCHANGE), addressing dissemination and exploitation.

assistant: **Impact**

Climate is changing at a global scale, exposing organisms to novel environmental conditions and potentially having a profound impact on life-history traits of individuals, and, hence, on the ecology, distribution and persistence of species. Among the most apparent effects of climate change are alterations in the phenology of many species as a result of changes in the timing of seasons. One of the most striking examples concerns the life-cycle of migratory birds: during recent decades a growing number of studies have reported a direct relationship between climate change and bird migration phenology, essentially showing that birds arrive earlier to their breeding grounds in the Northern Hemisphere, in accordance with a trend towards higher global temperature. However, the ultimate mechanisms by which these phenotypical adaptations occur are poorly understood. Two contrasting, non-exclusive, mechanisms may account for the observed responses: a microevolutionary response to selection and/or phenotypic plasticity. To explore which of these mechanisms operates and when, here we propose the combined use of long-term datasets of individually-marked migratory birds, their phenotypic and life-history traits and their fitness parameters, along with climatic data and pedigree information. We propose to identify which phenotypic traits have changed over time because of the influence of climate change, by using a range of statistical analyses and mathematical modelling (capture-mark-recapture methods, linear mixed modelling). Then, we propose to study the inheritance patterns of the most-influenced phenotypic traits using pedigree information and quantitative genetics methods (“animal models”). This combined use of ecology and evolution methodologies through heredity studies of pedig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Systems Neuroscience of Metabolism' (SYNEME) targeting Horizon 2020.

assistant: **Abstract**

Proopiomelanocortin (POMC)- and Agouti-Related Peptide (AgRP)-expressing, i.e. melanocortin neurons in the hypothalamus, are key regulators of feeding behaviour, glucose metabolism, autonomic responses and higher cognitive functions. They represent targets for fuel-sensing hormones like leptin and insulin that thereby control key processes in systemic energy and glucose homeostasis. Importantly, resistance to these fuel-sensing signals is known to contribute to the current obesity and diabetes epidemic. Consequently, altered POMC- and AgRP-neuron regulation in obesity contributes to the development of numerous metabolic alterations. Although the melanocortin neurons as central regulators of metabolism have been classified according to the expression of their characteristic neuropeptides, it has only recently become clear that even within these populations they represent distinct heterogeneous neurons with respect to their physiological regulation and the biological responses governed by their specific downstream neurocircuits. However, the molecular nature of heterogeneous POMC and AgRP neuron populations, their specific neurocircuitry architecture and their specific functions still remain largely unexplored. Therefore, we will employ a wide array of state-of-the-art molecular systems neuroscience and modern mouse genetics approaches to define (1) the anatomical distribution, (2) molecular signature, (3) neurocircuitry architecture, (4) regulatory principles, (5) specific biological functions, and finally (6) novel druggable regulators of these specific POMC and AgRP microcircuits. We anticipate that the new knowledge generated will not only provide novel insights into the fundamental principles of CNS-dependent control of metabolism but could also lead to targeting the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Membranous nephropathy : a model for solving organ-specific auto-immunity (OSAI)' (OSAI).

assistant: **Innovation**

Membranous nephropathy (MN) is a paradigm of organ-specific autoimmune disease which affects the kidney glomerulus, resulting in the formation of immune deposits, complement-mediated proteinuria, and renal failure. My group has recently identified 2 causative antigens (neutral endopeptidase and bovine serum albumin) in children, and 2 predisposing genes HLA-DQA1 and PLA2R1 coding for another antigen in adult MN. However, MN is most likely more complex, involving several antigen-antibody systems and immune response genes. To get a comprehensive view of self and food/environmental antigenic targets and of HLA and non-HLA trigger genes, and to design new rapidly acting therapies, I will develop novel technological approaches such as immunopeptidomics, and explore new pathophysiological and therapeutic concepts with 3 major objectives:1. Identify the immune response targets (epitopes) using unbiased approaches such as HLA-class II peptidomics, random peptide libraries, and sequencing of candidate genes starting with PLA2R12. Investigate trigger genes by next generation sequencing (NGS) of the HLA-D locus and of other genes involved in autoimmunity and disease progression, in 150 pairs of donors and recipients with or without recurrence of MN, a situation offering a unique opportunity to analyze effects of genetic background3. Revisit complement-related innate immunity by NGS sequencing of 18 complement regulatory protein genes in search of variants which may account for disease heterogeneity, by blocking C5b-9 formation with recombinant factor H in 2 murine models of MN, and by searching for C5b-9 antagonists by high-throughput screening of chemical libraries in podocyte cell-based assays.Our project will provide new biomarkers that will be used to set up reliable tests for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'HUMAN UTERUS CELL ATLAS', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The Human Uterus Cell Atlas (HUTER) project aims to create the single-cell and spatial reference map of the human uterus. HUTER project will provide unprecedented insight at transcriptomic, genomic and spatial changes of this important female organ not only throughout the menstrual cycle but also across lifespan. The human uterus is a flagship reproductive organ with profound implications not only in reproduction but also in women´s health. HUTER can advance the Human Cell Atlas initiative for the exploitation potential in Obstetrics and Gynaecology  and biomedicine research areas such as Regenerative Medicine or Reproductive Medicine. The uterus is itself a model for regenerative medicine since (i) endometrial tissue regenerates monthly and its transformation is executed through dynamic changes in states and interactions of multiple cell types, and (ii) myometrial tissue has remarkable regenerative capacity and extensive remodelling throughout pregnancy. Hence, the primary motivation HUTER proposal stems from the need to better understand the human uterus in order to more effectively address uterine diseases that impact women´s health such as myomas or endometriosis and/or might contribute to infertility, infant and maternal mortality and morbidity. HUTER technological and biological platform will be a crucial resource for the scientific and clinical communities to define the cellular basis of health and disease, allowing the rapid development of new diagnosis and prognosis tools and therapeutic advancements in the field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Haploinsufficiency and Intractable Epilepsy Rescue Increasing Endogenous Gene Promoter Efficiency' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This proposal will develop a new tool to rescue haploinsufficiency, which underlies many genetic disorders of neuronal excitability, and provide a new approach to treatment of intractable epilepsy. This new tool is based on the CRISPR-On technology which can regulate the expression of endogenous genes by directly targeting their promoters, which allows expression of the full panoply of splice variants and untranslated regulatory sequences. Importantly, the method does not require integrating exogenous genes into the genome, which has potential risks of insertional mutagenesis. Haploinsufficency of SCN1A, which encodes the sodium channel Nav1.1, leads to Dravet Syndrome, a severe epilepsy. My first aim is to increase SCN1A gene expression in interneurons derived by reprogramming fibroblasts obtained from Dravet Syndrome patients. I will then determine whether this strategy can be effective in non-genetic epilepsies by applying CRISPR-On technology to increase KNCA1(Kv1.1) expression in excitatory neurons in a mouse model of focal epilepsy. This project will combine my previous experience with functional analysis of neurons in different epileptic models; an unparalleled resource of genetically-characterized patients, a well characterized model of intractable epilepsy, and gene therapy techniques at the UCL Institute of Neurology; and expertise on the CRISPR-On method and fibroblast reprogramming of international collaborators. Epilepsy is one of the most important health burdens within the clinical neurosciences, and finding tools that open new mechanistic and therapeutic insights is a high priority. My proposal exploits an opportunity to establish a new tool to treat epileptic disorders and to create an international multidisciplinary network including neurophysiology, c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Work Toghether to Stop Truancy Among Youth'.

assistant: **Innovation**

Truancy is a serious public health problem that affects adolescents from all countries around the world. In the United States, it has been reported that up to 35% of high school students skipped one or more days of school during a school year. However, little is known on the short- and long-term outcomes of underlying psychological and mental ill-health for those adolescents who truant. Research has indicated that truancy has severe and far reaching consequences, such as maladjustment, substance abuse, delinquency and crime. Most studies, performed in the USA, proposed mechanistic and law-enforcement interventions to prevent truancy. However this approach doesn’t take in consideration the psychological distress that is associated with this phenomenon and may even have negative consequences on adolescents’ well-being and mental health. The main objectives of the WE-STAY (Working in Europe to Stop Truancy among Youth) project are to gather epidemiological information on truancy on European adolescents; to perform intervention school-based programmes for adolescents, aimed at reducing truancy rates and improve mental health of students; to evaluate outcomes of the interventions, in comparison with a control group, from a multidisciplinary perspective including social, psychological and economical aspects; to recommend effective, culturally adjusted models for preventing truancy and promoting mental health of adolescents in different European countries. The WE-STAY project proposes to implement and evaluate outcomes of three different kinds of intervention against truancy: a) a universal intervention based on an awareness program for students, teachers and parents; b) a screening intervention aimed at identifying students at risk and refer them to mental health services; c)