RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Early risk detection and prevention in ageing people by self-administered ICT-supported assessment and a behavioural change intervention delivered by use of smartphones and smartwatches'.

assistant: **Concept**

Lifestyle, disease and biology put older people at risk of functional decline, leading to falls, cognitive impairment, frailty, and negative consequences for quality of life. PreventIT will develop and test an ICT based mHealth System (iPAS) for the consumer market that 1) enables early identification of risk of age-related functional decline, and 2) engenders behavioural change in younger older adults in order to adopt a healthy, active lifestyle. We will use an integrated system of a smartphone/watch as frontend technology and a protected cloud-based solution for handling of personal data as backend technology. We will develop online instruments for risk-screening, complexity metrics, motivation for behavioural change, and a method for personalise exercise by phenotype, based on currently available big data sets. The ICT based intervention we develop is unique, delivered on a smartphone/watch with exercise integrated in daily life and a behaviour change programme. We will evaluate the role of technology and behavioural change theories in risk prevention by performing a multinational feasibility RCT to compare with the same intervention without use of technology and with practice as usual. Usability and feasibility will be in focus, and ageing people will be included in all phases of the project. At the end of the project all assessment and intervention components will be integrated into a personalised self-administered activity system, designed to empower ageing people to control their own health and function. A microsimulation health economics model will be developed to predict effects of our risk prevention intervention on carers and the health care system. PreventIT will be performed by a strong interdisciplinary team with previous impact in the field of ageing and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Women, Disability, and Inclusion – Scientific Excellence in Bulgaria' to be submitted under Horizon 2020.

assistant: **Abstract**

The objective of MILIEU (“woMen dIsabiLity and Inclusion – Scientific Excellence in BUlgaria”) is to create a networking collaboration between the Institute for the Study of the Societies and Knowledge of the Bulgarian Academy of Sciences (ISSK-BAS) and two high renowned Universities: Universidad Complutense de Madrid (Spain) and Università degli Studi di Genova(Italy), with the final aim of increasing ISSK-BAS scientific excellence and visibility, research innovation capacity and of enabling frontier research at the crossroad of studies on women, disability and inclusion. Such research topics are almost totally unaddressed in Bulgaria, therefore MILIEU will also bring significant research and societal impacts in the long term, as well as introducing a new line of research at ISSK-BAS and in Bulgaria, related to disability studies, feminist disability studies, and gender. For the achievement of its objectives, the project will rely on a variegated set of methods, such as: 1) interdisciplinarity and knowledge sharing, 2) capacity building, 3) participatory approach, 4) inclusivity and sustainability and 5) far-reaching methods for communication and engagement. The Twinning exercise will build on an appropriate set of key actions – with a strong focus on ESR engagement –from joint training and research paths, to bilateral meetings, from short visits to dedicated conferences and summer schools, leading to new research opportunities and joint research projects in the field. The organization of networking and outreaching activities, inter alia conferences and dissemination events as well as liaison activities with similar projects, will contribute to the visibility of ISSK-BAS and of the other EU partners in the field. Finally, to ensure transferability and uptake of results
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Real-Time Embedded Adaptive Learning for Wireless Communications' (REALCOM), addressing dissemination and exploitation.

assistant: **Impact**

Wireless communications play a critical role in today’s digital society, with growing demands for speed, reliability, adaptability, and energy efficiency. Yet, modern wireless transceivers still rely on fixed model-based designs developed decades ago, limiting their ability to cope with the increasingly complex and dynamic environments in which they are expected to operate in future generations. Artificial intelligence (AI) offers a promising alternative, enabling communication devices to learn and adapt autonomously. However, current AI methods are typically resource-intensive, static, and ill-suited for real-time operation on low-cost embedded hardware.REALCOM proposes a breakthrough: the development and prototyping of a new class of lightweight, continuously adaptive AI-powered wireless transceivers. These systems will operate in real time on software-defined radios (SDRs), demonstrating autonomous adaptation to varying environments without relying on hand-crafted models. Building on the scientific foundation of the ERC Starting Grant “FLAIR,” this project will extend our methodology beyond simulation to a working prototype operating in the widely used WiFi band. The project will culminate in a fully functional end-to-end system, where transmitter and receiver jointly learn to communicate more efficiently over time as practical realization of semantic communication.REALCOM will deliver a tangible proof-of-concept for a disruptive AI-driven communication paradigm, laying the groundwork for industrial adoption. It will explore commercial potential through early business development, IP protection, and stakeholder engagement, aiming to position REALCOM as a key enabler for next-generation wireless technologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Characterization of the tbp-tfiia-containing comlex, tac' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

EC cells are pluripotent cells that are widely used to study the regulation of gene expression during early developmental stages. EC cells can be induced to differentiate into a variety of cell types by retinoic acid (RA), by aggregate formation and by expression of the adenoviral 12S E1A oncoprotein. The coactivator p300 has been implicated in RA- and E1A-induced differentiation but the factors or activities that are downstream of p300 remained unclear. The Stunnenberg's lab have recently identified a novel basal factor, TAC, and provided firm evidence that TAC is a downstream target and effector of p300 activity. TAC is a stable transcriptional complex between TBP and TFIIA, it lacks classical TAFs, and is present and active in EC but not in differentiated cells. The acetyltransferase activity of p300 is crucial for the formation of TAC. Importantly, expression of p300 in differentiated cells instigated the formation of TAC from endogenous proteins. In this project, I will set out to unravel two aspects of the p300-TAC connection, using a combination of biochemical, cell system and in vivo approaches:(1) The role of p300 in TAC formation.(2) The role of p300 in TAC-mediated transcription. Collectively, these experiments are likely to shed light on the putative role of p300 (CBP) and its downstream effector TAC in differentiation of embryonal cells and to provide clues a to the target genes of TAC as well as to the general mechanism of gene trancription.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Differentiation and morphology of retinal precursor cells in the vertebrate retina' to be submitted under Sixth Framework.

assistant: **Abstract**

The aim of this proposal is to investigate the path of differentiation of retinal precursor cells in the vertebrate eye, using both medaka and zebrafish as model organisms. The neurons andglia of the retina all develop from a population of dividing precursor cells which have the potential to differentiate into any one of the cell types making up the mature retina.As precursor cells undergo terminal differentiation, they must coordinate cell fate choice with morphological changes so that the appropriate cells are formed in the correct position within the retina. Little is understood about how this is achieved in vivo. I propose to mark precursor cells with fluorescent proteins and use time-lapse confocal microscopy to follow precursor cells in the living embryo as they differentiate, in order to better understand the morphological and other changes that cells must undergo as they mature.This should give us a detailed picture of how retinal cells differentiate into functional neurons: a picture, which is currently lacking in the field. I also intend to approach the problem of how the retina is formed from a genetic perspective, using medaka mutants generated in the host laboratory. A number of mutants with retinal defects have been identified, whose molecular nature is unknown. I will map and clone one or more of these mutants, thus identifying new genes required for retinal development. This proposal will provide me with a wide range of new skills, which will be invaluable to me in my scientific career.In making the switch from Drosophila to fish, I will broaden my knowledge of developmental biology, and learn a set of new techniques for the study of vertebrate development and genetics. In addition, the scientific community of EMBL will provide a stimulating atmosphere i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Genetic control of proximo-distal leg development of drosophila' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content The main goal of the present project is the elucidation of the molecular mechanisms involved in the establishment of the proximo-distal (PD) axis in the appendages of Drosophila. As a first step, we will study the expression pattern and genetic interactions of genes known to have a role in this process, and a preliminary hypothesis on the relationships of such genes will be suggested. As mutants for these genes do not affect all parts of the leg, some other genes must be necessarily involved. Thus, a second objective is the identification of new genes required for PD patterning among enhancer trap lines, according to their expression pattern from embryo to pupa, and the integration of their function in the framework proposed for the previously known genes. Alleles of these new genes will be isolated from the enhancer trap lines or by mutagenesis, in order to find mutant phenotypes of PD pattern. A molecular analysis will be performed for the most interesting gene found. Cloning will proceed from plasmid rescue of DNA adyacent to the enhancer trap insertion. The coding sequence will be identified in the candidate cytogenetical region by coincidence of the expression pattern of transcripts with the one of the enhancer traps. Then, the gene product will be sequenced to identify its nature. Training content (objective, benefit and expected impact) The work described in the project implies learning several new techniques that are necessary in the analysis of gene function and expression. The results and skills obtained will also be useful in further research projects in other organisms and genetic processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mucosal vaccines against human and simian immunodeficiency viruses based on dendritic cells (MUVADEN)' (MUVADEN) targeting Fifth Framework.

assistant: **Abstract**

There is urgent need for HIV vaccines with high protective efficacy, low cost and simple immunisation schedule. Aim of this project is to assess in the macaque model the efficacy of(I) new vaccine candidates (lipid-DNA; single cycle lent viral vector; recombinant S.gordonii) made by our consortium;(ii) prime-boost vaccination strategies with/without adjuvant (GM-CSF, TNF-alpha, Cog motifs) and(iii) route of vaccine application (via the tonsils vs. potential) for inducing immunity and protect ion to mussel challenge. We also address to vaccine biology at dendrite cell level. With the oral route we target dendrite cells that are numerous at this site and mature them with adjuvant. Thus, we expect to see an enhanced immunity, a low viral set point (undetectable virus by infectious unit and RNA assays) or at least a reduction of viral load (100 RNA copies/ml of plasma), clinical well-being and normal CD4 counts and function.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Helping cancer survivors restoring their natural breast with resorbable implants inducing self‐tissue regeneration' (REGENERA).

assistant: **Concept**

Tensive was founded in 2012 to address the challenge of developing better biomaterials for regenerative medicine.  We developed a bio absorbable scaffold based on highly biocompatible polyurethaneester. Our patented scaffolds provide a synthetic micro-vascular network that enables adipocytes colonization in vivo. This unique design leads to vascularization, fat integration and volume maintaining after implantation.   Based on these unique properties, we will bring to the market REGENERA, an innovative mammary prosthesis that is degraded over time and replaced by the patient´s fat. Silicone implants, the most currently used breast tissue modifications, have important risks and need replacement every 10-15 years. Fat grafting, the best alternative nowadays, has been linked to carcinogenic risks and does not promote vascularization (leading to necrosis) with multiple interventions needed for large reconstructions.  REGENERA, which only requires one surgical intervention, will meet the need to develop biomaterials able to promote new blood vessels formation that perpetuate the reconstructed tissue.   REGENERA will have a significant impact on various levels: (i) Healthcare system: it will save the cost of additional surgeries (more than €241M yearly in the EU), helping to the sustainability of the Healthcare system. (ii) breast cancer patients: it will offer a solution to lumpectomy patients, for whom there are no good solutions yet; a better alternative for mastectomy and breast augmentation patients; a permanent solution by a single surgery for all patients, improving their quality of life. (iii) company: it will increase Tensive’s revenues (cumulative profit of €257M with a ROI of 19.37 by 2025) (iv) society: it will highly benefit 230,000 women needing reconstructive su
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ArchitecturE for Service-Oriented Process - Monitoring and Control' (IMC-AESOP) under Seventh Framework.

assistant: **Objectives**

IMC-AESOP will investigate a Service-oriented Architecture approach for monitoring and control of Process Control applications (batch and continuous process). Large process industry systems are a complex set of multi-disciplinary, connected, heterogeneous systems that function as a complex system of which the components are themselves systems. They link many components from individual groups of sensors to e.g. whole control, monitoring, supervisory control systems, performing SCADA and DCS functions.The future Perfect Plant" will enable monitoring and control information flow in a cross-layer way. Components can be dynamically added or removed and dynamic discovery enables the on-demand information combination and collaboration. All systems will collaborate in an enterprise-wide system of systems, dynamically evolving based on business needs.IMC-AESOP deals with several key challenges that arise such as real-time web services, interoperability, plug and play, self-adaptation, reliability, cost-effectiveness, energy-awareness, high-level cross-layer integration and cooperation, event propagation, aggregation and management.  Using SOA we will go to complex infrastructures linked in a cross-layer way from devices to enterprise systems. Transition from legacy systems will be studied for existing ones. The SOA-based approach proposed by IMC-AESOP will simplify the integration of monitoring and control systems on application layer.IMC-AESOP will demonstrate the application feasibility in pilots. The use cases provided from several end-users will be demonstrated in pilot applications. Engineering tools, application modelling and methodologies will be investigated and highlights on the future of the domain will be provided by research and academic partners. The IMC-AESOP partn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development and field test of an efficient YBCO Coated Conductor based Fault Current Limiter for Operation in Electricity Networks' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The project aims at developing a unique device for electricity networks: A superconducting fault current limiter (SFCL) based on coated conductor YBCO tape (cc-tape) or 2nd Generation HTS tape. The general trend in Europe to a higher meshing of distribution networks and the rapid growing integration of renewable energy sources leads to an increase of the fault current level by every new installation. As substations ratings are coming to their limits network operators have to either decline additional installations to their grids or to upgrade if not rebuild complete substations. The SFCL provides a solution to deal with the increasing incidence and level of fault currents and will contribute to improving the performance, stability and efficiency of electricity grids. It can be applied as a new tool for grid operation and will enhance the flexibility for further grid planning. SFCL are considered to be the most attractive superconducting devices as they offer unparalleled features compared to conventional techniques such as automatic ultrafast and effective current limitation, no external trigger (fail safe), rapid self recovery and negligible impedance during operation. In contrast to conventional solutions resistive type SFCL are also suitable for higher voltage levels. So far developed SFCL prototypes based on BSCCO material are exhibiting significant AC-losses at higher currents which oppose their commercial introduction. Today, the availability of cc-tape in longer lengths at reasonable cost makes a commercial breakthrough of FCL possible with unique features such as compactness, short recovery-time, low AC-losses. Leading industrial and academic institutions from Europe have teamed up to design, build, and test the first full 3-phase cc-tape FCL worldwide. The devi