RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Information Flow in Opportunistic Wireless Networks' (INFLOW), addressing dissemination and exploitation.

assistant: **Impact**

The objective of INFLOW is to develop the methodology and algorithms for the modeling and analysis of optimal information flow in future wireless networks, thus leading to the design of new network protocols and algorithms. Building on recent breakthroughs in network information theory and in distributed systems, the aim is to leverage the potential of networks consisting essentially of wireless and mobile nodes.Advances in this area will have a significant impact on the possibilities of the future Internet. Portable devices with ubiquitous wireless connectivity have the potential to revolutionize the personal computing landscape, creating opportunities for unprecedented applications and services. But, standing in the way of this vision are challenges spanning the entire system architecture, due to the distinct characteristics of the wireless medium. To overcome such challenges, further research investigations focused on the understanding of the fundamental properties of complex wireless systems are needed.The first goal consists in pushing the theoretical performance limits of mobile and wireless networks, taking into account the state of the art results in network information theory, and thus focusing on two emerging key principles: opportunistic networking and network coding. Thus, we propose to study dynamically changing networks, i.e., networks where the structure, topology, and demands may vary in a short time scale as compared to the information transfer. The proposed interdisciplinary approach draws on advanced mathematical models, founded on information theory, stochastic analysis, the techniques developed for the analysis of algorithms, and statistical physics inspired methods to study the emerging behavior of large-scale networks. But, the goal is to deliver
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Biogas market expansion to 2020' (BIOGASMAX).

assistant: **Innovation**

The overall goal of the project is to reduce dependency on oil, reduce greenhouse gases and direct emissions through increased and more efficient production, distribution and use of biogas in the transport sector generated from a wide variety of feedstock available in urban areas and regions in Europe. The project adopts the well-to-wheel approach to identify the potential for efficiency gains and cost optimisation to ensure market expansion. BIOGASMAX anticipates making a strong response to the EC policy objective to replace 20% of petroleum-based fuels in the transport sector with 5 - 8% biofuels, 10% natural gas, and 2% hydrogen.During the 4-year life of the project, BIOGASMAX aims to:-prove the technical reliability, cost-effectiveness, environmental and societal benefits of biogas fuels;-perform large-scale demonstrations to optimise industrial processes, experiment and benchmark new and near-to market techniques and expand biogas fleets;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Exon trapping insert consortium' to be submitted under Fifth Framework.

assistant: **Abstract**

A network of laboratories will be formed to create a large population of gene-trap insertions in the genome of Arabidopsis thaliana to detect the spatial and temporal expression patterns of approximately 5.000 genes, and to identify and characterise the regulatory elements of these genes. Data obtained on the genes, in which transposons are inserted, will be obtained by sequencing the insertion site and this will be related to genome sequence and expression patterns in a functional genomics database. Gene expression patterns in a wide range of tissues and conditions will be defined and put in the database. The products of research will be a powerful resource to analyse the function of 20% of the genes in Arabidopsis, and these will be exploited by industrial partners.The EXOTIC project has generated 25,367 gene trap lines. This collection stands beside the CSHL collection of 18,764 gene trap and 14,204 enhancer trap lines (http://genetrap.cshl.org/servlet/CurrentStats). These collections, when available via stock centres and comprehensively described, will be a key asset for understanding gene function and gene expression in Arabidopsis. Table 2 describes the current status of gene disruption in Arabidopsis. The AtIDB database shows that 80% of the 29,000 predicted genes harbour disruptions. This represents outstanding progress towards the community goal of generating disruptions of all genes by 2005. It also shows that EU activities (GABI-KAT, Flag, Garnet and EXOTIC) have contributed nearly half of the lines available for gene disruption. It is likely that the random insertion strategies used with such success so far will not be cost effective in reaching the remaining 20% of genes, so new approaches will be needed. Here transposon insertions, which can be re-mobilise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Computational Aspects of Statistical Confidentiality', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The growing need for more and more detailed statistical information has an increased impact on the confidentiality issues. The increased computing power of the end-users has led to greater threats of disclosure of confidential information. This project aims at the enhancement of tools and the development of new methods for disclosure limitation. New software tools for both the protection of microdata and tabular data will be developed. The research is aimed primarily at new methods for releasing business microdata while new optimisation methods will be developed for the protection of hierarchical tables.Objectives:The research and development of new techniques for Statistical Disclosure Control is the main objective of this project. The need for more statistical information has a consequence that we should pay more attention to the confidentiality aspects. The impact on the Statistical Offices is very big if we fail to solve this problem adequately. The project will aim at the development of practical tools as well as new research to support the development of these tools. Attention will be paid to both tabular data as well as microdata. The development of these standard tools serves the harmonisation of the statistical production in Europe and will enforce the leading role of Europe in this topic.Work description:The work in this project can be divided in two main streams, which is reflected in the composition of the project team.The team includes both NSI's and universities:1. The disclosure protection of microdata. In the field of microdata several new techniques will be investigated and also implemented in m-ARGUS. The traditional techniques (global recoding and local suppression) serve quite well for microdata on individuals, but are inadequate for business microda
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Optimization of process, quality and cost as well as clinical tests of the wearable miniaturized fall detection system for the elderly'.

assistant: **Objectives**

During the previous FP7-SME–2008–1-FallWatch Research programme, a miniaturized fall detection device, Vigi´Fall™ has been developed, achieving the following characteristics and performances:- Ergonomics: Vigi’Fall has been miniaturized to a scale 50% smaller than current devices. Additionnal biocompatible materials for the casing and the adhesive patche make it comfortable and easy to stick to the user’s skin- Reliability: to tackle the high rate of false alarms that hinder the market, the FALLWATCH Consortium has develop a enhanced data fusion algorithm that crosses check accelerometers and heartbeat frequency meter monitored by the wearable device and infra red environmental information from the user’s homeThe present project will represent the next step, i.e. the progression from research developments and lab-prototype to industrialization and commercializable products. It will aim at:- Adapting the technology to the US standards, controlling the performances  of the device, optimizing the component selection, process and overall cost- Organizing clinical trials to demonstrate and validate the high performances of Vigi”Fall- Obtaining CE marking and FDA clearance to launch Vigi’Fall to the EU and US markets- Develop the best business strategy and commercialization routesFALLWATCH Demo will offer to the market a new generation of practical, easy to use and install, reliable fall detector, which thanks to a strong supply chain of SMEs (Vigilio, BSE, PMBL & Plastod) and a large company (AEMtec) will enable an enhanced quality of life to millions of European citizens, saving more than 10.000 hospitalizations and above 3.000 premature deaths caused by falls.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Industrial Exploitation and Market Uptake of a Temporal Cognition Toolbox for Commercial Robots' (ENTIMENT) under Horizon 2020.

assistant: **Objectives**

ENTIMENT aims to assess, deploy and commercialize a novel Temporal Cognition Toolbox (TCT) that greatly facilitates the development of time-aware robots, capable to engage in prolonged, symbiotic interaction with humans. In doing so, it significantly capitalizes on the successful research and development activities on artificial time perception, pursued within the FET-funded project TimeStorm, which aims at equipping robots with a human-like sense of temporality and the ability to perceive the temporal aspects of the world. The already available and tested robotic temporal cognition modules implemented in TimeStorm by partner FORTH, will be refined and integrated into the TCT, that will further be released as an open source ROS node for robotic developers. TCT will furnish robots with the ability to perceive the inherent temporal dimension that is inevitably present in human-machine confluence. The latter will have a major impact in mainstream sectors of robotic applications, including service robots, companions, entertainment platforms, etc. ENTIMENT has already compiled a Focus Group of companies interested in the exploitation of TCT in contemporary and future commercial robotic systems under a licensed agreement. Temporal cognition is certainly not an optional extra but a necessity towards the development of truly autonomous and intelligent machines that are seamlessly and actively integrated into human societies. The implementation of highly competitive, temporal-cognition enabled robots will enhance the innovation potential of FET projects, contributing at the same time in the market and economic growth of Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Marine Pollution in the Black Sea due to Mining Activities: Risk As sessment, Development of Preventive and Remedial Action.' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Foreseen ResultsBased on the above, the appropriate integrated environmental management scheme will be proposed in order to improve water quality in the Black Sea and safeguard the survival of the endangered ecosystems.Exploitation of polymetallic sulphide, radioactive and phosphate ores has been associated with severe and widespread environmental degradation for the following reasons : mining and processing of these ores inevitable result in the creation of millions of tonnes of wastes (containing high residual concentration of toxic elements : Cu, Pb, Zn, As, Cd, Hg, nuclides) that, at least in the past, have been deposited without any precaution on the land (terrestrial deposition) or, in many cases, into the sea (marine deposition). Under physical (wind) or chemical (leaching) mechanisms, the toxic elements are mobilized and migrate to the surrounding, causing severe and widespread contamination of soils, ground, surface and marine waters.The extensive underground mining works, which remain active for tens of even hundreds of years after closure, are also a continuous source of acid mine drainage loaded with toxic elements causing severe terrestrial and sea water pollution. All sources (mining works, tailings deposits) remain active for tens or even hundred of years after minng closure.Three areas on the Black Sea will be used as case studies :(i) the Vromos Bay (BG) where 8mt of copper flotation tailings containing residual heavy metals and radioactive elements have been deposited on the sea shore and furthermore, mining and processing wastes deposited terrestrially are releasing acid waters heavily contaminated that pollute the surrounding soils and eventually reach the sea.(ii) The Mouth of the Danube River (RO) where flotation tailings of a polymetallic sulphide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Tourism and leisure policies in European rural regions, current trends and future prospects - a thematic study on sustainable development'.

assistant: **Innovation**

In recent decades, there has been a rapid growth in the demand for leisure use of the countryside. Nowadays, most European rural areas can supply available resources and good qualitative conditions for sustainable tourism and outdoor recreation. According to the objectives of the European Commission, this new reality could promote regional development and assist in restructuring local economies. The success of development policies will depend on a careful approach and on a well defined tourism planning. Common policies and public investments promoting the protection of the natural and cultural heritage are a field with significant potential for social and economic development in rural communities. This research project aims at improving the sustainable tourism competitiveness and the quality of life in the European rural territories, especially those included in the less-favoured regions. This is the case of Cantabria. If tourism is to improve the welfare of the local communities and the environment of rural areas, then there is a real need for research on rural tourism planning and policies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The first in-class non-opioid drug for treating moderate, severe, and persistent pain with no addiction nor tolerance' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Tafalgie Therapeutics is a biopharmaceutical research company developing a new scientific approach for next-generation treatments, based on a true breakthrough innovation derived from the mechanism of action of an endogenous protein modulating the pain signal. Our ambition: to become the reference player in the field of pain medication by designing and proposing new active pharmaceutical ingredients for non-opioid analgesics, in a context marked by the opioid crisis, through the development of first-in-class polypeptides derived from TAFA4 and its peptide derivatives. We aim to develop and bring to patients more effective, well-tolerated, non-addictive, long-term treatments for the relief of acute pain - mild, moderate, and severe -, as well as for the prevention of chronic pain.


**Keywords:** Pain treatment, Non-opioid analgesic, Endogenous protein, Bioproduction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'From protein sequence to function – computational and experimental de-orphanization of uncharacterized enzymes in fungi' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Fast advances in genome sequencing and sequence processing technology leave ~30% of predicted proteins as orphans, meaning without known function or closely related enzymes. Being able to assign a function to such orphans opens avenues to select for and design powerful biocatalysts – individual enzymes, biosynthetic pathways or entire organisms. The herein proposed research aims at developing a de-orphanizing pipeline “fORPHAN” based on computational and experimental characterization of enzymes from the fungal kingdom. Fungi are known to be prolific producers of secondary metabolites, however, the study of the underlying biosynthetic gene clusters is still a fairly young field. The use of automated search and annotation pipelines is currently limited by the small number of experimentally characterized genes and gene clusters that can be used to train the algorithms. Therefore, I propose to use deep targeted database searches to identify key biosynthetic enzymes in the publicly available genomes of fungi. First targets will be the thus-far uncharacterized family of putative chalcone isomerases and the recently discovered family of type III polyketide synthases, which both have great potential for in vivo and in vitro applications. Several gene candidates will be expressed in vitro and in recombinant microbial hosts, and tested for activity on a range of substrates. Interesting candidates will also be characterized by X-ray crystallography. This research will not only yield biotechnologically-relevant catalysts but also provide the bioinformatic foundation for more challenging genome mining projects.


**Keywords:** Flavonoid biosynthesis, biosynthetic gene clusters, biocatalysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mitochondrial Synthesis of Neurotransmitters in Synaptic Function and Memory' under Horizon Europe.

assistant: **Concept**

Released neurotransmitters must be replenished at extraordinarily fast time scales to support synaptic function, circuit physiology and behavior. However, how axonal metabolism responds to the demands of neuronal activity to preserve neurotransmitter levels remains poorly understood. While our understanding of the biochemical pathways for neurotransmitter synthesis is vastly detailed, very little is known about how these pathways are implemented in mammalian axons to preserve synaptic function and behavior. I hypothesize axonal mitochondria sense neuronal activity and boost their metabolism to provide metabolic precursors that locally replenish glutamate and GABA (γ-aminobutyric acid), the main neurotransmitters of the mammalian nervous system. This localized synthesis ensures rapid refilling of activity-emptied synaptic vesicles, thereby safeguarding synaptic strength and brain function. MitoTransmitters aims to reveal a central role for axonal mitochondria in neurotransmitter metabolism, underscoring the importance of mitochondrial physiology beyond the classical bioenergetics. To do so, we will i) combine high-throughput optophysiology measurements of synaptic function together with the development of novel optical sensors for cytosolic glutamate and GABA, defining the metabolic pathways preserving synaptic function in excitatory and inhibitory neurons. We will also ii) integrate these findings at the behavioral level by developing novel optogenetic activators of mitochondrial metabolism and examining the role of mitochondrial neurotransmitter synthesis in long-term memory in rodents. By generating for the first time a comprehensive picture of the molecular mechanisms actively preserving neurotransmitter levels, this study will provide a theoretical and experimental
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Do hosts control parasite diversity? - an experimental study on soay sheep and their parasites' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

We aim to determine the mechanism by which a host can gain parasite resistance by investigating the inter- and intraspecific diversity of parasitic nematodes of soay sheep with genetic markers. Furthermore we will develop a fast bulk screening method for parasitic nematodes.