RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mechanisims of nuclear self-assembly' (Organelloids), addressing dissemination and exploitation.

assistant: **Impact**

Shape and function of the vertebrate nucleus depend on the choreographed interplay between lipids, proteins, and DNA to form the nuclear envelope. Even small molecular changes, such as point mutations in the proteins of the nuclear envelope (the lamina) cause detrimental human diseases including premature aging, cancer, and heart disease. To date, a clear, mechanistically compelling explanation for the dynamic coupling of lipids, proteins, and DNA to safeguard nuclear shape and function is still missing. We here propose to build minimal, synthetic nuclei (‘Organelloids’) bottom-up as a tool to study the self-assembly of a functional nucleus. We recently discovered the conserved molecular machinery that ensures the assembly of the nuclear envelope in open vertebrate mitosis. Our data point to uncharacterized fundamental mechanisms that couple the fusion of lipid-membrane sheets into a continues nuclear membrane to the formation of the lamina, and the organization of chromatin in the same chain of events.In this proposal, we will leverage our recent advances in reconstitution to build ‘Organelloids’ to recapitulate shape and function of the membrane-lamina-chromatin confluence. Using these nuclear Organelloids we will resolve the nuclear assembly process in high resolution by applying integrated structural biology and determine the unknown biophysical principles that drive the self-organization of individual molecules into one functional organelle. Our strategy will reveal the unknown hierarchical relationship between lipids, proteins, and DNA and produce detailed mechanistic models for the formation and coupling of functional subdomains that are commonly observed in the nuclear membrane, the lamina and chromatin. With cell models and top-down approaches we ultimately aim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Artificial Intelligence and Computer Vision for real-time diagnosis of public spaces' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Urban Data Eye brings to the market UDE, a paramount innovation for real time diagnosis of public spaces taking data captured from existing live urban cameras. UDE solves the main needs for three important market segments: 1) Smart Cities, where there exist a loss of profitability in many shops and real estate assets caused by saturation of public spaces, lack of use or insecurity; 2) Commerce, lacking precise urban data to help in the location of stores or measure the impact of window displays, urban ads or digital screens; 3) Security (detect urban terrorism, suspicious behaviour and insecure spots). To cope with these needs we have developed three product lines: Urban Public Eye (up to 30% effectiveness in urban decision-making and 1.5% reduction in GHG), Urban Business Eye (+50% gain in marketing campaigns) and Urban Security Eye (predict over-crowding and dangerous situations). Success cases developed at the Callao Square in Madrid and Market Square in Pittsburgh prove the current TRL6 stage. During the Feasibility Study we will perform a technical, commercial and financial feasibility assessment, so as to define the requirements to enhance the predictive models and the cloud analytics functionality, and make a platform scalability study for each market segment. Regulation, distribution channels and IPR issues will also be addressed, along with detailed economic projections and analysis of funding requirements. Regarding benefits to society, accurate urban diagnosis will be fundamental in achieving the 17 Sustainable Development Goals of the 2030 Agenda for Sustainable Development. To cope with this challenge, UDE addresses Goal 11, by making cities and human settlements inclusive, safe and sustainable.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Tuning of dye-sensitized particles in nano-structured solar cells'.

assistant: **Concept**

The project is aimed at the investigation and application of a new group of dye molecules to the dye-sensitized nano-structured solar cell (NSC) . The molecules under investigation are metal complexes with 2, 2' : 6'2 ' ' - terpyridine and 2, 2' bipyridine ligands, which are substituted with thiophene groups. The thiophene substituent was chosen for two reasons:Initial calculations have shown that these complexes have favorable electronical properties.Secondly, the thiophene substituent is a starting point for polymerization reactions. A modification of the starting compounds with oligomer or polymer chains will be performed on the surface of TiO2. The resulting material will be incorporated into the NSC. This procedure is based on a patented method o f the group of Dr. A. Hagfeldt, which does not involve a high-temperature step for the transformation of TiO2 powder into nano-structured material. Beside the application to the solar cell, a fundamental scientific investigation of the properties for the group of molecules will be conducted (electrochemistry, spectroscopy, photo-electrochemistry). This includes a mechanistic study of the electron transfer between the dye molecules and the TiO2 particles, and between the dye and the redox active material in the electrolyte. In conclusion, the project should result in an investigation of surface reactions of TiO2 bound complexes, the application of this material to the solar cell and insights about this new group of dyes .The two years at the host institution would enable me to apply my knowledge in the fields of electrochemistry, metal complex chemistry and surface sciences to the solar cell . I will be able to learn new techniques like the assembling of the NSC and its characterization (IV-, IPCE- and stability measurement
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Conservation Heritage Architecture, buildings and sites by Resilient Methods:  hydro-climate factors'.

assistant: **Concept**

The doctoral network CHARM (Conservation of Heritage Architecture, buildings and sites by Resilient Methods:  hydro-climate factors) aims to train 13 doctoral candidates in response to unfulfilled recruitment needs in research and innovation sectors on cultural heritage conservation and restoration. The Research partnership is constituted of 12 beneficiaries and 11 associated partners. CHARM puts together researchers from universities and research organisms (12 academic beneficiaries), 1 national and 2 local organizations in charge of Cultural Heritage conservation, 2 Small and Midsize Enterprise, 2 industrial producer of building materials, and 2 Non-Governmental Organization, from 9 European and 1 South American countries.CHARM develops new sustainable conservation and restoration solutions, adapted to the current and future climate conditions, designed in a circular economy philosophy, having a low environmental footprint and high handprint. CHARM also responds to socio-economical requirements of wellbeing and proposes conservation/restoration solutions economically acceptable and respecting the cultural value of buildings.CHARM proposes a holistic approach including: i) site observation and data collection, ii) data preparation to be used by AI, models, etc, iii) methods for understanding and modelling past and future degradation of architectural heritage, iv) sustainable conservation solutions to several observed problems, v) assessment of the impact of architectural conservation on the environment and of the environment (past, present and future) on architectural heritage, vi) bidirectional  interactions with society proposing risk management plans but also taking into account the society wills and needs.CHARM develops a durable training program consisting of acad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'The development of a food quality and management system for the control of Mycotoxins in cereal production and processing chains in Latin America south cone countries'.

assistant: **Objectives**

Food Safety and quality is a major research topic due to the increasing concern of consumers with public health related issues, along with the stronger sanitary standards set by the EU for agriproduct importation. Mycotoxin contamination of food and feedstuffs is among the top priority issues regarding human and animal safety, along with the economic losses they are responsible for. Although several mycotoxin surveys have been performed on cereals in the Latin America South Cone countries, the surveillance data are incomplete and widely dispersed. The control of mycotoxins is currently pursued mainly through quality control and regulatory procedures. However, the analytical methods (mainly chromatographic) currently used for mycotoxin determination need sophisticated equipment and trained analysts, which makes them unsuitable for routine on-field assessment. There is an urgent need for other accurate, simple and cost-effective techniques. There is also an urgent need for a systematic/proactive, cost-effective approach towards the control of mycotoxins throughout the agrifood chains. The proposed project will address the methodological and analytical issues associated with the establishment of a Food Quality Management System (FQMS), for controlling mycotoxins in cereal chains, in Latin America South Cone countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Topoisomerase Function in genome and epigenome regulation during Neuronal Differentiation' under Seventh Framework.

assistant: **Concept**

Transcriptional regulation defines the identity of pluripotent and differentiated cells. DNA Topoisomerases are enzymes that catalyze the unlinking of the DNA strands by making transient DNA strand breaks and allowing the DNA to rotate around these breaks, a process essential for DNA replication, transcription, chromosome condensation and segregation (Champoux, 2001). A mammalian-specific distinct type of topoisomerase, topoisomerase II beta (TopIIβ), is only abundantly expressed in terminally differentiated cells and is required for neurogenesis (Yang et al, 2000). TopIIβ is proposed to act at the ‘potentiation’ level of transcription to make gene promoters amenable for transcription as a prerequisite for their subsequent development-specific activation. This function could be achieved by regulating higher order chromatin organization of target genomic regions and/or direct interaction with known partners such as condesin and PcG proteins (Lupo R. et al., 2001) and other epigenetic modifiers such as chromatin remodeling complexes. We propose to define the contribution of TopIIβ activity towards epigenetic regulation of neuronal differentiation. We will combine a sophisticated in vitro mouse differentiation system with genome-wide identification of TopIIβ target genes. These will be directly related to existing datasets on development-specific targets of DNA methylation and Polycomb marking (Mohn et al., 2008).To delineate how these local characteristics translate into spatial organization of chromosomal regions we will study genomewide networks of chromosomal interactions for selected target genes using the 4C methodology. This will be functionally complemented by analysis of mouse stem cells lacking topoisomerase II beta protein. We ultimately aim to generate a model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The First Soft Robotic Glove for Hand Injury Prevention and Rehabilitation' to be submitted under Horizon 2020.

assistant: **Abstract**

i-Hand is a soft robotic glove that can add extra strength to the grip and increase grip function for a) persons who perform intense manual labor/sports and want to prevent any hand issues, b) persons who want to reduce the risk of occupational injuries related to manual activities at work or home and c) persons recovering from hand problems. The first generation of the glove (SEM glove) generated €1M of sales an average price of 4100 Euros in 2016. The second generation of the glove (i-Hand) is a modular platform that can be used to develop different product variants tailored for different markets, and that has been optimized for volume production. This is a disruptive innovation for medical rehabilitation and worker health & safety as users can - for the first time - use the device at home or at work, without needing expensive/voluminous specialized equipment (rehabilitation robot or work exoskeleton). The i-Hand glove has a slim design and the same look and feel as a regular glove with a weight under 70g. Mini-actuators and high performance batteries provide enough strength to support activities at work or at home for 8-16 hours without recharge, while keeping the total weight of the system under 400g. The device production cost will be able to reach below 180 Euros at volumes > 500-1000 units. The project will conduct user trials in 3 concrete scenarios (assist, rehab and prevent) in order to gather additional evidence of its benefits and provide end-user iterative feedback. Bioservo has already closed agreements with leading partners such as OttoBock (orthopaedic devices), Hocoma (rehabilitation systems) and already has collaboration agreements with GM, NASA, GE, Airbus and Eiffage. The glove is also endorsed by key stakeholders such as Swedish Employment Service,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Lyric Poetry in Venice in the Heterodox Renaissance (1545-1657)' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

LyrPo will be the first comprehensive study of the impact of Protestant ideas on lyric poetry produced in Catholic Venice in the Tridentine and Post-Tridentine era. It will explore a significant aspect of the complex relationships between Catholics and Protestants of the time, during a period of censorship and mutual religious condemnation, by analysing an extensive corpus of lyric poems written in both Italian and Latin by a diverse array of women and men authors. The project will focus on an examination of those Venetian lyric texts that dealt with religion, morality, and politics, while variously expressing heterodox thoughts, which tended not to be overtly heretical (to avoid censorship), yet were subtly influenced by Reformation-inspired ideas.Protestantism was, indeed, present in Venice in the considered period. From the rise of the Reformation, the Republic of Venice was one of the Catholic states more open to Protestantism. It was also one which remained partially out of step with Counter-Reformation regulations up to the mid-seventeenth century, hence it remained somewhat more receptive to Protestant ideas for longer. Within this context, Reformation-inspired ideas informed and were reflected in literary works too, including lyric poems, which expressed heterodox thoughts in a wide gamut of ways.Studying what Protestant ideas were received, in which lyric texts, in what language, and by which authors is at the core of my research, which will combine and be built on the methodologies central to Literary, Gender and Reception Studies, and History of Religion and Ideas. In so doing, LyrPo will help to further our understanding of Renaissance literature, as well as the histories of lyric poetry, early-modern European culture, and the Christian Churches. Furthermore
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Restorative Justice as a Challenge for the New Milennium' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

While victim-offender mediation programs are the predominant form of restorative justice philosophy and practice, newer and more creative forms of restorative justice such as family group conference, sentencing circles and peace circles are unknown or utterly neglected in the European. The latter have the advantage that they are especially well suited to deal with minority and immigrant groups since they take their cultural background, values and traditions into account. The aim of all restorative justice programme is to restore peace in the community after an offensive/crime has been committed and traditional penal solutions of such matters seem to have failed or take not into account all the stakeholders and their interests/needs in order to restore justice in the community. In addition are new forms such as community-and problem oriented policing and new forms of social services such as communities that care more or less based on a restorative justice philosophy. The proposed conference is supposed to evaluate these new forms of restorative justice, discuss their merit and how people, communities and societies in Europe can benefit from them, how they can be implemented and evaluated in the various forms and countries.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00379-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Functional significance of nociceptive primary sensory neurons diversity' (PAINEURONS) under Seventh Framework.

assistant: **Objectives**

Unravelling the precise in vivo function of a particular neuronal subpopulation is one of the most challenging issues in neurobiology. Nociceptive primary sensory neurons represent a powerful model system to address this fundamental question. These neurons convey a large cohort of perceptual sensory modalities including thermal, mechanical and chemical stimuli from the periphery to the spinal cord. Nociceptive neurons encompass an extremely heterogeneous population with respect to their morphological, anatomical, electrophysiological and molecular properties. In spite of the efforts, the functional significance of this remarkable diversity has remained elusive. Our proposed project, show our contribution to the expansion of the repertoire of molecules specifying discrete subsets of primary nociceptive neurons and describes original and highly versatile mice models in which the loci of our favourite genes have been genetically engineered to allow conditional gene inactivation and inducible cell ablation of discrete nociceptive neuronal subtypes. Molecular, anatomical, physiological and behavioural analyses of such models will allow to (i) unravel the role of each of our favorite genes in the specification/function of the sensory neuronal subtypes and (ii) correlate discrete subsets of nociceptive neurons to clearly defined sensory modalities. Understanding how diversity in neuronal phenotypes is accomplished is only the first step to deepen into the mechanisms of pain. If we know how a precise neuronal subtype is generated, we can subsequently analyze not only basic aspects of its physiology, but also more medically oriented aspects like its functional role under pathological conditions, its chronic changes in response to inflammation and analgesic treatments