RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Pilot Optical Line for Imaging and Sensing'.

assistant: **Objectives**

The KET pilot line project POLIS is aimed at maintaining and furthering the innovation capability of CMOS image and optical sensors in Europe. An existing ST CMOS high volume production line, unique in Europe, will serve as the basis of the proposed project. The strategy behind POLIS lies in the development of specific technological modules and to implement them at pilot line level on the existing production line. POLIS will also enable the development of several key demonstrators representative of potential final products serving multiple applications. More specifically, in order to support imaging expansion into new markets (automotive, consumer, medical, security), the project proposes to focus on the following application fields: sensors capturing photons beyond visible wavelength range, focusing on the limits of spectral range (X-ray/Gamma and thermal IR/THz), sensors using Time of Flight (ToF) technology and light emitters based on OLED on silicon technology for micro-displays.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'EXPloiting Empirical appRoaches to Translation' in the context of a Seventh Framework call.

assistant: **Objectives**

Automatic translation is an undeniable need in a globalized world where communication using several languages becomes increasingly more relevant. Translation Memory (TM) and Machine Translation (MT) systems are the two most elaborate technologies to support human translation. Recent developments in the area of Example-based and Statistical Machine Translation (EBMT and SMT), in particular, have shown the potential of data-driven approaches for producing fast and low cost translations. A number of user studies have however established shortcomings in the state-of-the-art of these technologies, including poor quality translations for low resource languages, interfaces that do not take into account user requirements and user feedback, etc. We propose the creation of an Initial Training Network to train young researchers on ways to improve current data-driven MT technologies (TM, SMT and EBMT) by exploiting their individual strengths through their combination and by addressing some of the main limitations of each of these technologies. Leading academic and industrial partners in all data-driven translation technologies, along with both professional translators and end-users of translation technologies will support young researchers of the network during the whole research and development cycle, providing guidance, core and complementary training skills and evaluating the resulting technologies. A comprehensive set of training materials on core and complementary skills developed during this project will be made freely available to other researchers interested in the field. We expect the training of researchers in the new skills required for the development and use of technologies that can increase productivity and reduce costs in the translation sector, as well as facilitate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Sharing Cities'.

assistant: **Concept**

Sharing Cities has four key objectives.  1) To achieve scale in the European smart cities market by proving that properly designed smart city solutions, based around common needs, can be integrated in complex urban environments.  This will be done in a way that exhibits their true potential and allows for the significant scale-up and consequent increase in social, economic and environmental value. 2) Adopt a digital first approach which proves the extent to which ICT integration can improve and connect up existing infrastructure, as well as the design and running of new city infrastructure.  This will also allow for the creation of a new set of next stage digital services which will help citizens make better and beneficial choices around energy efficiency and mobility, which when scaled up will enhance the city’s ability to hit key targets for mobility, housing, energy efficiency and resilience, and economic development. 3) Accelerate the market to understand, develop and trial business, investment and governance models, essential for the true aggregation and replication (through collaboration) of smart city solutions in cities of different sizes and maturities. In doing this, we intend to accelerate the pace by which we make transformative improvements, and enhance sustainability in communities. 4) Share and collaborate for society: to respond to increasing demand for participation; to enhance mechanisms for citizens’ engagement; to improve local governments capacity for policy making and service delivery through collaboration and co-design; resulting in outcomes that are better for citizens, businesses and visitors.  These will be delivered by a range of expert partners across 8 work packages.


**Keywords:** sharing, accelerate, scale, funding, growth, digital, integ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Archimedes 2001 - 'molecular cloning and characterization of the gamma-hydroxybutyrate receptor and other neuronal orphan receptors'', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Natural products provide an important source of compounds for new medicines. Even today, approximately 25% of all prescription drugs used in the industrialized world are derived from natural products. Part of the reason for this is that natural sources provoke access at chemical diversity, which cannot be invented on purely chemical grounds. In this application, research is described which aims at development of new neuropharmacological agents based on an earlier discovery of the structure of a neuroactive toxin from the parasitic wasp Philanthus triangulum F . THE BEE WOLF AND PHTX-433 Philanthotoxin-433 (phTX-433) is a polyamine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New Frontiers in Optimal Adaptivity' (OPTIMAL).

assistant: **Concept**

The ultimate goal of any numerical method is to achieve maximal accuracy with minimal computational cost. This is also the driving motivation behind adaptive mesh refinement algorithms to approximate partial differential equations (PDEs).PDEs are the foundation of almost every simulation in computational physics (from classical mechanics to geophysics, astrophysics, hydrodynamics, and micromagnetism) and even in computational finance and machine learning.Without adaptive mesh refinement such simulations fail to reach significant accuracy even on the strongest computers before running out of memory or time.The goal of adaptivity is to achieve a mathematically guaranteed optimal accuracy vs. work ratio for such problems.However, adaptive mesh refinement for time-dependent PDEs is mathematically not understood and no optimal adaptive algorithms for such problems are known. The reason is that several key ideas from elliptic PDEs do not work in the non-stationary setting and the established theory breaks down.This ERC project aims to overcome these longstanding open problems by developing and analyzing provably optimal adaptive mesh refinement algorithms for time-dependent problems with relevant applications in computational physics.  This will be achieved by exploiting a new mathematical insight that, for the first time in the history of mesh refinement, opens a viable path to understand adaptive algorithms for time-dependent problems.  The approaches bridge several mathematical disciplines such as finite element analysis, matrix theory, non-linear PDEs, and error estimation, thus breaking new ground in the mathematics and application of computational PDEs.


**Keywords:** adaptivity, mesh refinement, optimal convergence, a posteriori error estimator
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Realizing Web Service Discovery at Web Scale' (Service-Finder) targeting Seventh Framework.

assistant: **Abstract**

The Web is moving from a collection of static documents to a collection of services. For realizing service interchange in a business to business setting, the service-oriented architecture together with the Web Services technology are widely seen as the most promising fundament. As a result, considerable attention has been given, both in research and in industry to Web Services and related technologies. <br/>In addition a paradigm shift in the usage of the Web in general has happened. The role of a Web user is shifting from a passive, only consuming function to one where he actively participates: the so called Web 2.0" phenomena. Both Web Service's technologies and Web 2.0's technologies have been used in order to develop applications. However, up to now these two areas have been kept separate: the applications that use Web Services do not use the Web 2.0 approach, and vice versa. Instead, Service-Finder aims at developing a platform for service discovery in which Web Services are embedded in a Web 2.0 environment."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Digital twins bringing agility and innovation to manufacturing SMEs, by empowering a network of DIHs with an integrated digital platform that enables Manufacturing as a Service (MaaS)' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The DIGITbrain project is deeply rooted in the innovation ecosystem of the I4MS project CloudiFacturing and the industrial platforms FIWARE and IDS, and it will build on these results, by means of extending the CloudiFacturing solution with an augmented digital-twin concept called “Digital Product Brain” (DPB) and a smart business model called “Manufacturing as a Service” (MaaS). By having access to on-demand data, models, algorithms, and resources for industrial products (i.e. mechatronic systems supporting the production of other products), the DBP will enable their customisation and adaptation according to individual conditions. The availability of industrial-product capacity will facilitate the implementation of MaaS, which will allow manufacturing SMEs to access advanced manufacturing facilities within their regions or to distribute their orders across different ones. The DIGITbrain project will address four principles that will foster the uptake of advanced digital and manufacturing technologies. A) Technology: leverage edge-, cloud- and HPC-based modelling, simulation, optimisation, analytics, and machine learning tools and augment the concept of digital twin with a memorizing capacity that records the provenance of the industrial product over its full lifecycle. B) Feasibility: support more than 20 highly innovative cross-border experiments, bringing together technology providers and manufacturing end users, and facilitating cost-effective distributed and localised production, based on on-demand manufacturing machine capacity. C) Sustainability: coach and empower DIHs to implement the smart business model MaaS and contribute to their long-term sustainability, by increasing their portfolio with services tailored to the industrial needs of their regions. D) Networ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Concurrent engineering approach for durability optimisation of trucks applying an integrated fatigue & dynamics methodology oncurrent engineering approach for durability optimisation of trucks applying an integrated fat(igue & dy)namics met' in the context of a Fourth Framework call.

assistant: **Objectives**

Durability optimisation is an essential, but costly and time consuming part of the design and refinement process of trucks. Competitiveness requirements imposing shorter design cycles put forward the need for a more effective and reliable approach to the durability optimisation that makes optimal use of previous experience and similar designs. This is particularly critical for the truck industry because many variants are required to satisfy widely varying market demands. The main objective of the project is to develop integrated design tools for durability assessment and optimisation of trucks, which combine numerical prediction methods with tests on physical prototypes on laboratory test rigs and on test tracks in a closely co ordinated manner. First, a fatigue strength information system will be developed that allows to take maximum advantage of a company's internal durability experience on previous similar designs. Second. structural modelling techniques will be developed that allow in the design phase of a truck to efficiently optimise a component for durability, without the need for complete recalculation of the structural model of the truck. Third, tools will be developed to generate improved, customer oriented but time reduced loading environments for use in both numerical predictions and accelerated fatigue testing on test tracks and test rigs. Finally, tools to improve quality and effficiency of test rig fatigue testing will be implemented. Overall, these elements will be tightly linked and integrated in order to obtain an efficient concurrent, CAE/CAT driven design process for durability optimisation. As structural dynamics (vibrational behaviour) has an important impact on the fatigue performance of trucks, a combined fat(igue & d)ynamics methodology will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Prolonged inhibition of semaphorine3a pathway via a bio-degradable implant towards a better therapy for visual sensory impairments' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The visual pathway is a component of the central nervous system (CNS) and therefore is not regenerative. Acute optic nerve injury, ischemic optic neuropathy and glaucoma are conditions that initially lead to partial blindness and eventually could lead to total blindness. Extensive neuron and retinal ganglion cells (RGC) death is evidenced in these pathologies. Semaphorin 3A (Sema3A) is a cell secreted protein that participates in the axonal guidance pathways. Partner TAU was the first to show that Sema-3A is also capable of inducing neuronal cell death. Elevated levels of Sema3A were than found in glaucoma. TAU further showed the viscous role of Sema3a that is mediating the vast RCG apoptosis following optic nerve injury. Importantly, marked inhibition of RGC loss was achieved when axotomized eyes were co-treated by intravitreous injection of antibodies against the Sema3A providing the proof of concept for the therapeutic approach to inhibit the Sema3A pathway following optic nerve injury. This concept was recently validated by partner SIC who developed a small molecule weight inhibitor of Sema3A and showed that this inhibitor promotes neural regeneration of damaged axons. Acute or chronic assault to neural cells create an immediate death of part of the population and a signal for further death of the remaining cells close to the damaged area. The project goal is to develop a therapeutic approach to stop further death of neural cells by providing prolonged inhibition of the apopototic pathway of Sema-3A using antibody targeted to this protein or a low MW inhibitor of sema3A. The Sema3A inhibitors would be constantly released from a novel intraocular biodegradable implant.  The clinical efficacy of this approach will be evaluated in two common devastating pathologies: op
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Role of genetic and non-genetic mechanisms in furan risk' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The proposal will address modes of action for tumour induction in liver by the food contaminant furan, which is formed by processing of food resulting in widespread human exposure. There is uncertainty regarding the relevance of tumours induced in rodents to human risk assessment because the mechanisms are unclear. The research will address the role of DNA and protein binding of furan, oxidative DNA damage, non-genotoxic alteration of proliferation and apoptosis, cytogenetics and cytotoxicity in furan-mediated liver toxicity and carcinogenicity. A combination of in vivo and in vitro systems, analytical chemistry, cell biology and omics" technologies will be applied. In rodents in vivo, extent and dose-dependence of covalent binding to DNA, cytogenetic changes and geno- and cytotoxicity in target cells in the liver will be addressed after oral administration of furan. In addition, the induction of oxidative DNA-modifications and mechanisms of mutations will be investigated in genetically modified rodent models. These in vivo studies will characterize the mode of action of furan and also address irreversible metaplasia, changes in cell signaling and inflammation. The interaction of these effects with possible genetic changes in liver cells including aspects of forced cell proliferation will be included. The in vivo work will be complemented by studying mode of mutation of furan and its metabolite cis-2-butene-1,4-dial in cell culture models resembling the target cells. The content of furan in food will be determined and human exposures will be assessed using probabilistic modeling. Mechanisms of formation of furan in food may open ways to reduce exposures. The results will provide data on the mode-of-action of furan induced liver carcinogenesis as a basis for a conclusive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Metastable Epiallele: Role of Epigenetic Variability for the Development of Metabolic and Endocrine Diseases'.

assistant: **Innovation**

The development of obesity in industrial and low-and middle-income countries is leading to a severe burden for patients and health care systems based on associated comorbidities as cardiovascular diseases and type 2 diabetes mellitus. Apart from the genetic background, epigenetic modifications like DNA methylation are supposed to play an important role for body weight regulation. So far, epigenome-wide association studies were not able to elucidate this relationship, as most methylation differences were related to a genetic variant. Therefore, the identification of the POMC (pro-opiomelanocortin) gene, a key factor for hypothalamic body weight regulation, as a metastable epiallele in humans, was of importance to understand how methylation variability affect the individual phenotype. Metastable epialleles are methylome-regions, which are non-genetically determined, stochastically regulated and set in early embryonic development. Furthermore, they are non-tissue specific, stable over time and modified by Carbon-1 metabolites in-utero. However, their role for human diseases remained unclear. Within this application, I want to elucidate and characterize how epigenetic modifications as metastable epialleles modulate human susceptibility and predisposition to metabolic and endocrine diseases and analyse the impact of environmental factors. To achieve this goal, I propose a unique approach using advanced technologies to analyse human postmortem samples and human embryonic stem cells to identify new metastable epialleles in humans and elucidate new mechanisms and relationships between phenotypic variation and methylation variability. The combination of the algorithm to identify methylation variability and the use of stem cell models to functionally characterize epigenetic varia