RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Unveiling the Molecular Basis of RNA Interference with Single Molecule Fluorescence'.

assistant: **Innovation**

Recent groundbreaking discoveries have changed our view on RNA from that of a passive information carrier to an important regulatory element. MicroRNA is a small regulatory RNA that controls nearly all mRNAs in eukaryotic cells. Since this regulation process (termed RNA interference/RNAi) occurs in a sequence-specific manner, we can manipulate gene expression using custom-designed small RNAs. This remarkable discovery introduced the possibility of RNA-based gene therapy and triggered intensive research on the RNA-induced silencing complex (RISC), the core machinery of RNAi. The molecular mechanism of RISC is, however, poorly understood due to the limited spatial and temporal resolution of traditional tools, which has deterred development of an RNAi assay applicable to medical sciences.I will use single-molecule fluorescence to investigate the entire process of RISC action with high spatio-temporal resolution. From ‘RISC assembly’ through ‘target mRNA search’ to ‘target mRNA degradation,’ it requires the cooperative action of multiple RISC components. As the protein-protein and protein-RNA interactions are dynamic processes, it is challenging to study them in bulk where the interactions are diffusion-limited and subsequent processes are masked from observation. With single-molecule microscopy, I will observe all the processes in real time and quantitatively examine the kinetics. In addition, I will dissect the complex processes of RISC action by observing multiple RISC components simultaneously, using multicolor FRET that I have developed. Furthermore, to elucidate the complex nature of RNAi, I will reconstitute protein complexes with a single-molecule immunoprecipitation technique that I have recently innovated.This first single-molecule study on RISC will enable us to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Continuous structural condition tank integrity monitoring of Above Ground Storage Tanks, aka “SafeAST, no entry: no empty.”' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The purpose of this action is to assist the €2.8bn European and global liquid storage and distribution industry in reducing the costs involved in ensuring that leaks do not occur from 500,000 above ground storage tanks (ASTs), thus avoiding avoid damage to the environment and the loss of revenue from the unscheduled outages of leaking tanks, currently estimated at €132m.   At its core is the exploitation of Plant Integrity’s proven non-invasive storage tank floor monitoring technology capable of detecting defects as small as 25mm.Plant Integrity’s SafeAST system provides continuous structural condition monitoring of ASTs, detecting any corrosion hotspots in the internal tank floor without the need to empty the tank and manually inspect the welds.  Plant Integrity provides this continuous monitoring by integrating its long range ultrasonic testing (LRUT) with sophisticated sensors and systems in order to detect defects in the annular ring and bottom plates.The principal aim of this action is to provide final pre-launch confirmation of performance data to demonstrate the capability of SafeAST in detecting time-dependent degradation of the AST tank floor.  The secondary aim is to provide a package of comprehensive launch material (including validated Technical Reports, supportive marketing material, final hardware specification and software sign-off) to aid a successful launch.  The five-strong SafeAST consortium comprises the Tüpras oil and gas company which operates tank farms, research and academic organisations, plus client-facing industrial product development consultancies.  Its Vision is to create a highly profitable, sustainable company (cash positive in 2 years, turnover €24m in four years) capable of delivering both hardware and services worth €80k pa to the AST
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Personalized Tissue-Engineered Veins as the first Cure for Patients with Chronic Venous Insufficiency' (P-TEV) targeting Horizon 2020.

assistant: **Abstract**

This project will commercialize P-TEV - a unique personalized tissue engineered vein for the treatment of patients with severe Chronic Venous Insufficiency (CVI).CVI is a progressive medical condition in which the valves of the deep veins of the leg are not functioning properly. The most severe stage is CVI with leg ulceration. No effective treatment is available, and a large number of patients would directly benefit from venous vascular surgery. These patients cannot be cured today because no suitable grafts for replacement of the dysfunctional venous valves have yet been developed. There are no synthetic products which could replace the function of the bicuspid valves found in the leg veins and the risks associated with allotransplantation are too high.VERIGRAFT’s technology is the first one positioned to break this paradigm and fill the existing market gap. The technology allows the personalization of blood vessels by de- and recellularization. In short, a donated tissue is decellularized, removing all immunogenic donor cells and DNA. This results in a clean extracellular matrix scaffold with intact 3D structural properties. Subsequently, this scaffold is seeded with the patient´s own cells, derived from a small sample of peripheral blood.This unique technology turns an allogeneic (“foreign”) tissue into an autologous (“personalized”) one and thus avoids transplant rejection without the need for immunosuppression.The clinical proof-of-concept for P-TEV is established. The project will include the clinical study and GMP process development that will grant VERIGRAFT market access by 2019 and serve as a steppingstone to marketing approval by the European Medicines Agency.The EU-added value of the project is unparalleled, as it constitutes a breakthrough in one of future
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Creativity in learning through Social Computing and Game Mechanics in the Enterprise' (COLLAGE) targeting Seventh Framework.

assistant: **Abstract**

Much social creativity involves human collaboration through and about artifacts that embody collective knowledge resulting from the collaboration. It can be a catalyst to enable European SMEs and large organizations to adopt and sustain new approaches to learning by fostering non-linear and non-standard thinking and allowing promising ideas to be transformed into new processes, products, services or business models. To this end COLLAGE will exploit new synergies between the social Web phenomenon, emerging Web analytics, collaboration and gaming technologies to energize and enable social creativity in learning. It will design, develop and validate an innovative cloud-enabled Social Creativity Service-Set that will support the interlinking of learning processes and systems with (i) social computational services for inspiring learners, (ii) social affinity spaces for leveraging expression and exploration, and (iii) social game mechanics for supporting social evaluation and appreciation of creative behaviour. The COLLAGE service set will be applied to enhance creativity in the learning processes of: FIAT SEPIN, which provides training to the Fiat Group and its automobile ecosystem; CEDEP, the executive education consortium; and WAAG, the creative technology society. COLLAGE will aim to generate: (a) economic impact by enabling SMEs and large organizations to capitalize on the creative capabilities of their employees through new value creation; (b) technological impact by advancing leading edge technologies (context-aware computing, web analytics and social computational systems) towards creativity support; (c) impact on TEL by providing an open-source service-set for social creativity able to mash-up with existing learning processes and solutions; and (d) scientific impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Quasi-opportunistic supercomputing for complex systems in Grid Environments' to be submitted under Sixth Framework.

assistant: **Abstract**

Many real-world systems involve large number of highly interconnected heterogeneous elements. Such structures, known as Complex Systems (CS), typically exhibit non-linear behaviour and emergence. While Europe's developing knowledge industry requires an understanding of complex systems, the traditional reductionist approach used by science is challenged to give any answers.A more holistic approach is needed to explore these behaviours. The methodologies used to understand their properties involve modelling, simulation and often require considerable computational resources such that only supercomputers can deliver. However, many knowledge-based industries lack the resources to deploy or maintain such a computing capability. Currently there is no grid technology with the capability to harness the available grid resources and provide a computationally equivalent to a supercomputer service. This project's aim is to develop core grid technology capable of providing quasi-opportunistic supercomputing grid services and technology.Whereas supercomputing resources are more or less dependable, the grid approach is characterized by an opportunistic sharing of resources as they become available. This distributed quasi-opportunistic supercomputing, while not offering the quality of service of a supercomputer, will be to some degree better than the pure opportunistic grid approach. Furthermore it will enable users to develop applications with supercomputing requirements without the need to deploy supercomputers themselves. The test bed used to evaluate this quasi-supercomputing grid technology, will be a number of diverse complex system modelling applications operating as part of complex problem-solving environments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Using ex vivo functional genomics as biomarker to predict the effectivity of Venetoclax in patients with acute leukemias' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

For decades, oncologists treating cancer patients desire biomarkers that predict drug sensitivity on a patient individual level; unfortunately, the challenge remains unsolved until today. As treating clinicians are unable to identify the patients who benefit most and despite advanced multi-omics diagnostics, the majority of cancer patients are treated according to risk groups. As a result, patients receive inactive drugs without benefit, but adverse effects and European healthcare systems lose significant resources without gain. During my ERC CoG work, we developed a completely new test principle which has the potential to bridge the gap. The group of “targeted” anticancer drugs causes tumor cells to die by inhibiting a single specific signalling molecule; we used the CRISPR/Cas9 mediated gene knockout to mimic the activity of such targeted drugs. In proof-of-principle work, we used patient-derived xenograft (PDX) leukemia models to show that the knockout of a target gene in vitro was able to predict which patient´s PDX model responded to treatment with the respective drug in vivo. Here, we plan to optimize our test system by studying knockout of BCL-2 to predict sensitivity to the BCL-2 targeting drug Venetoclax. The planned work harbours the potential of a major breakthrough to solve a long-standing challenge in anti-cancer treatment, namely to predict which individual patient´s tumor responds to which targeted.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Integrated geophysical exploration technologies for deep fractured geothermal systems'.

assistant: **Concept**

The share of renewable energy sources in the European energy balance can be increased by a meaning-ful contribution of geothermal energy. Since the mining cost (exploration and drilling) to access the re-sources represents over 60% of the total investmen t, a reduction in mining cost would increase the com-petitiveness of geothermal energy significantly. This goal can be achieved if we had a way to detect the presence of the fluids inside the natural and/or enhanced geothermal systems before any drilling opera-tion. The project I-GET is aimed at developing an innovative geothermal exploration approach based on ad-vanced geophysical methods. The objective is to improve the detection, prior to drilling, of fluid bearing zones in naturally and/or artificial ly fractured geothermal reservoirs. This new approach will be tested in three European geothermal systems with different geological and thermodynamic reservoir characte-istics: two high enthalpy (metamorphic and volcanic rocks) and two middle/low enthalpy geothermal system (sedimentary rocks). Petrophysical and geomechanical properties of the investigated rocks will be defined by laboratory measurements. Elastic and electric rock properties will be determined at the steam/liquid transition of the pore fill ings. The validity of the laboratory and simulation results will be verified by new field ex-periments. Seismic and magnetotelluric data will be acquired in the test sites, and new acquisition and processing techniques will be developed to solve problems related to the particular target such as high tempera-tures, anisotropy, phase condition, etc.. The static and dynamic three-dimensional model of geothermal reservoirs will be reconstructed by means of all the data acquired. Results will indicate to which extent the g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Collective signaling oscillations in embryonic patterning –  revealing underlying principles'.

assistant: **Innovation**

In this proposal, we study collective signaling oscillations during embryonic patterning. Signaling oscillations during vertebrate embryo segmentation are governed by a molecular oscillatory machinery referred to as segmentation clock (Palmeirim et al., 1997). The segmentation clock is linked to periodic activity of the Notch, Wnt and Fgf pathway in presomitic mesoderm (PSM) cells (period~2 hours in mouse embryos). Importantly, PSM cells display complex, collective synchronization and, as a result, wave-like activity patterns (phase waves) sweep periodically along the embryonic axis. We have previously shown that phase waves are an emergent and collective phenomenon in PSM cells (Tsiairis and Aulehla, 2016).  Conceptually, this proposal builds on our previous discovery that the relative timing between Wnt/Notch oscillations is critical for proper mesoderm patterning (Sonnen et al., 2018). What are the principles underlying the emergence of collective synchronization and how do PSM cells decode relative timing of signalling oscillations?  As outlined in this proposal, we are now in a unique position to address these fundamental questions in novel ways. Importantly, we have established an entrainment strategy that enables, for the first time, precise experimental control of oscillation dynamics (Sonnen et al., 2018). Our strategy is to further expand the entrainment approach, including the future use of optogenetics, and also combine it with our expertise in quantitative, multi-scale analysis of signalling dynamics and functional, genetic perturbations.   A central aim of this ERC proposal is to build on discoveries made in versatile in vitro assays that we developed and to address their significance in vivo. To this end, we propose a novel line of research using the meda
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Empower citizeNs to join Forces with public authORities in proteCting the Environment' (ENFORCE), addressing dissemination and exploitation.

assistant: **Impact**

Assuring environmental compliance requires a strong network of stakeholders, from citizens and researchers to governments and environmental organisations. Through creative toolkits and protocols, ENFORCE aims to tackle the frequent mismatch between the environmental data gathered by citizens and what authorities require for enforcement purposes. The project will address the challenges in data reporting coming from both the citizens side and the authorities’ side, in order for the obtained data to be usable for environmental enforcement. In this line, ENFORCE introduces the concept of Data Readiness Level (DRL) to assess the maturity of data to be used as evidence in environmental compliance cases. In addition, the project will capitalize on the use of geo-spatial intelligence and AI-enhanced tools, strengthening their capacities, promoting good practices and preparing an inventory on geo-spatial intelligence and AI use. The proposed solution will ensure alignment with the Green Deal Data Space to ensure trustworthy data exchange among the relevant stakeholders. The project encompasses 8 case studies that involve all relevant actors including grassroots organizations, local and regional authorities and a diverse group of experienced researchers forming a scientifically robust interdisciplinary team. The lessons learnt and evaluation results from the case studies will feed the replication guidelines that will be promoted through the ENFORCE capacity building programme and associated policy recommendations to create a multiplier effect for the adoption of citizen science data to support environmental compliance.


**Keywords:** Environmental Compliance; Green Deal Data Space; Geospatial Intelligence;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Openings to the Inclusion of Muslim Minorities in Today’s Democracies' under Horizon 2020.

assistant: **Concept**

At the heart of contemporary politics in the old democracies in Europe and North America is a significant puzzle. How come the far right, advocating a nativist agenda particularly opposed to Muslims and Islam, is advancing at a time when public opinion research documents stability or decline in illiberal values in these populations at large? Current studies understandably focus on accounting for exclusion – opposition to Muslims, prejudice, islamophobia, and nativism. In the INCLUDE project, I propose to expand the scope of inquiry beyond drivers of exclusion to investigate the openness of non-Muslim majorities to the inclusion of Muslim minorities. I ask, under what conditions—on what terms—are they open to inclusion? This research question brings conceptual and empirical attention to different aspects of public opinion and different segments within the public than are currently at the center of attention in research on intergroup attitudes and support for the far right. A major program of new data collection is needed to test the new hypotheses and implications raised. To manage the risks involved in taking research in a new direction, I propose to collect data in sequences of survey experiments in a few countries where we already have a solid base of knowledge to build upon—Norway, Germany, France, the UK, the Netherlands, and Sweden. The potential gains are considerable: The proposed new framework narrows down the conditions under which exclusionary actors, such as the far right, are likely to gain political influence. It highlights different aspects of the strategies and policies adopted by inclusive actors than are currently in focus. It identifies polarization traps that can fuel mistrust between “people” and “elites.”  All in all, the project can bring forth vit