RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structure of Membrane Proteins by Electron Microscopy and Image Processing' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The major objective is to solve the three dimensional structure of two membrane protein complexes using electron crystallography.1. The complex between the bacterial toxin colicin N and porins. The key point is to visualize structural changes that occur when the initially soluble toxin, mediated by porins, inserts and translocates into membranes. This mechanism is currently poorly understood, but the work is facilitated by availability of two-dimensional crystals of the complex and atomic coordinates of both molecules.2. Opioid receptors, which mediate analgesic action and the addictive properties of morphine-derived compounds, modulate pain controlling pathways, mood and reward. They belong to the group of trimeric G protein-coupled receptors with seven membrane helices. The structure of these important receptors is not known even at low resolution.This project will give me an excellent training and knowledge in:1. Biochemistry and crystallization of membrane proteins2. High-resolution electron microscopy including specimen preparation, imaging and image processing.Both projects are potentially important for pharmaceutical industrial interests in toxicology and analgesic /addictive drugs. The Pattus group has also established collaboration with the Astra pharmaceutical company on the functional studies of delta opioid receptor.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Natural Food formulation for the prevention and treatment the Obesity and Metabolic syndrome obtained with herbal extracts' to be submitted under Horizon 2020.

assistant: **Abstract**

After a four-year program of research and development MONTELOEDER has identified highly active components in well-known and safe herbal extracts (Hibiscus sabdariffa and ; Lemon verbena) that preclinical results shows to modulate triglyceride accumulation, oxidative stress and inflammation in insulin-resistant adipocytes and their capacity to decrease body weight, serum cholesterol and triglycerides levels and hepatic steatosis signs in a hyperlipidemic mouse model subjected to high-fat diets.Based on this results, MONTELOEDER will put in the market a natural functional food ingredient, based on the selected combinations of the two herbal extracts that exhibit synergy in their ability to activate AMPK –enzyme, for the treatment and prevention of overweight and conditions associated with Metabolic Syndrome (MetS). The new formula is characterized because of its high polyphenolic content, high water solubility and produced under the main “Green Extraction” principles.One of the most evident health concerns worldwide is the obesity and other pathologies related with the metabolic syndrome (MetS), which is is a growing epidemic throughout the world. It has been estimated that in people over 50 years of age, metabolic syndrome affects more than 40% of the population in the United States of America and nearly 30% in Europe. And this number is expected to double over the next 15 years.There are economical and health issues in the necessity for developing food ingredients for the prevention and/or treatment the obesity and Metabolic syndrome. Despite the large number of products classified as functional foods ingredients, there are only two natural products targeted to MetS, which are not allowed in Europe and U.S.A. markets.The new product could reach a sales volume during 201
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Advanced aeroacoustics'.

assistant: **Concept**

Aero acoustics remains one of the most challenging domains and its evolution is fast. Noise effects on fatigue are recognised as affecting both the security and efficiency of those who suffer it professionally or in their daily life. An accurate knowledge of the mechanisms of aerodynamic noise is required to fulfil present day norms. The course updates of the state of the art in noise prediction. The contents combines modelling, numerical approach at different levels of approximation and discussion of experimental test cases allowing the evaluation of the performances and applicability of the methods presented. Lectures will be delivered in a fast accessible form. The lecturers are high-level scientists presenting their recent results and able to explain how to apply the most recent methods to industry. At the end of the course, the participants should be able to carry out the methods presented and to optimise their use in their own domain.The target people are both young researchers and industrial engineers:- European companies, belonging to sectors like transport (airplane and road vehicles) or safety (noise in working environment, vibration-induced mechanical fatigue) capable to use correctly the techniques should significantly improve their competitiveness;- Once trained efficiently in this field, young postgraduates and PhD students should find an employment more easily.Though the sessions realised by the organisers are all in the field of Fluid Dynamics and Energetics, the topics selected and the lists of related experts strongly vary each year. Therefore, a global project regrouping the sessions does not seem adequate. Such a highly specialised course should neither be renewed at less than a two years distance.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-0024
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Role of estrogen signaling to astrocytes in the hypothalamus in the development of obesity.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Obesity is a complex condition that causes around 1.6 million deaths each year.  The metabolic alterations to an obesigenic environment are highly dependent on the sex of the individual. In the brain, the hypothalamus controls energy homeostasis by fine tuning feeding and energy expenditure to nutrient availability. Disruption of this regulation results in obesity. While hypothalamic neurons are crucial for the control of energy balance, their activity is tightly dependent on adequate delivery of energy substrates provided by astrocytes, the major type of glial cells in the brain. Whether nutritional challenges evoke sex-specific astrocyte adaptations and its contribution to the sex-dimorphism in the pathogenesis of obesity remains unknown. Interestingly, estrogen signaling is an essential target that mediates sexual differentiation in the brain. This project’s main aim is to determine the role of estrogen signaling in astrocytes in: 1) hypothalamic astrocytic adaptations to obesity, 2) energy metabolism in lean and obese conditions and 3) in the beneficial effects of incretin-based therapies against obesity. The present proposal intends to combine interdisciplinary expertise in astrocyte biology and neural control of metabolism to expand the understanding on the involvement of hypothalamic astrocytes in the development of obesity in a sex-dependent manner. The cutting-edge approach of ex vivo and in vivo astrocyte-selective targeting of estrogen signaling in specific hypothalamic areas, extends beyond the neuro-centrist approach by demonstrating that functional remodeling of hypothalamic astrocytes in response to nutrient overload represents a key step for the development of novel cell-selective therapeutic approaches for treating obesity and associated pathologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Performance Optimisation of Metasurface-Assisted Secure Integrated Sensing and Communication Systems', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Reconfigurable Intelligent Surface (RIS)-assisted integrated sensing and communication (ISAC) is emerging as a key technology for future wireless systems, particularly in monitoring and managing network-connected unmanned aerial vehicles (UAVs) with line-of-sight (LOS) links. ISAC transmitters can use echo signals to detect the angle of arrival of unauthorized UAVs and leverage channel information to enhance secrecy rates.Motivated by these unique capabilities, we aim to optimize the performance of RIS-assisted secure ISAC systems. Our objectives are: 1) to develop a RIS-based collaborative sensing mechanism to mitigate asynchronous reception effects and improve sensing performance; 2) to design methods for unauthorized target detection and sensing and communication (SAC) channel parameter prediction based on perceived information; 3) to create algorithms for joint optimization of resource allocation, RIS phase shifts, artificial noise (AN), and UAV trajectories to maximize the secure transmission rate of ISAC systems.Achieving these objectives will provide immense benefits to the wireless industry and sectors advancing 5G/6G technologies. The Fellow anticipates that the project outcomes will reduce network deployment costs for mobile network operators by 30%, while enabling high-quality mobile data services for citizens, boosting the digital economy, and creating new jobs.


**Keywords:** Integrated Sensing and Communication, Reconfigurable Intelligent Surface, UAV Communication, Secure Transmission, Collaborative Sensing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Doped diamond devices and sensors'.

assistant: **Concept**

Young researchers will be trained in all techniques that will equip them to take part in the commercial exploitation of diamond as an electronic material. They will learn techniques used to grow device-grade diamond, to introduce the impurities that control its properties, and to exclude those that degrade its operation. They will learn how to characterize the defects by the scientific techniques that are productive for diamond. They will be trained in the design, fabrication, testing and optimization of diamond electronic devices. They will spend time at several laboratories in the network, in order to be trained in the complementary skills offered at those laboratories, and also to gain experience in several European countries. The range of skills that they will learn will not only put them at the forefront of the commercial exploitation of diamond electronics, but will also train them in generic skills which will be valuable in the semiconductor and IT industries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Sewage sludge gasification for chp applications (CHP SEWAGE GASFN)'.

assistant: **Concept**

A strong consortium, comprising industry, industrial R&D organisations and Universities will examine all major steps involved in the gasification of sludge. Technical, environmental and economic issues will be addressed, including the identification, quantification and characterisation of different sludges, and examination of issues associated with their handling, preparation, transport and feeding. Sludge gasification performance will be assessed using alternative gasification technologies and the fuel gases produced characterised. Associated environmental issues of the release, production and abatement of fuel gas contaminants will be studied. The data generated will be assessed (techno-economically) examining the effectiveness of the various gasification technologies and their application to CHP systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Higgs bundles: Supersymmetric Gauge Theories and Geometry'.

assistant: **Innovation**

String theory provides a unified description of particle physics and gravity, within a consistent theory of quantum gravity. The goal of this research is to develop both the phenomenological implications as well as conceptual foundations of string theory and its non-perturbative completions, M- and F-theory. Both, seemingly independent, questions are deeply connected to a mathematical structure, the Higgs bundle, which characterizes supersymmetric vacua of dimensionally reduced gauge theories, and insights into the moduli space of Higgs bundles will result in a fruitful cross-connection between these subjects.For string theory to engage in a meaningful dialog with particle physics, it is paramount to gain a universal understanding of the low energy effective theories that can arise from it. Building on the success of studying F-theory vacua in terms of Higgs bundles, we propose to develop the Higgs bundle approach for M-theory on G2-manifolds, leading to a universal characterization of the low energy physics. Methods developed for Higgs bundles of d = 3 N = 2 theories obtained from M5-branes on three-manifolds will be used in this process. Associated to each Higgs bundle is a local G2 manifold and we propose a way (using new results in geometry) to construct compact G2 spaces associated to these, which manifestly ensure the phenomenological soundness of the compactifications.Higgs bundles have recently also played a key role in studying the compactifications of the M5-brane in M-theory. We propose and develop a new duality between a d = 4 theory on a four-manifold X4 and a d = 2, N = (2,0) supersymmetric gauge theory on a two-sphere S2, obtained by considering the M5-brane theory on X4xS2. The supersymmetric vacua have a characterization in terms of Higgs bundles, which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Growing Inequality: a Novel Integration of transformations research' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

GI-NI aims to contribute to an inclusive Europe of shared prosperity, by providing a better understanding of the changes and joint impact of three major transformations: technological progress, globalisation and migration; and offering policy and governance solutions to better equip citizens and companies, securing more equal opportunities and outcomes. We use a multidisciplinary research approach by a top-tier consortium with international stakeholder engagement throughout the project. GI-NI has five objectives: 1. Measure impacts of the three transformations on work, skills, and inequality; 2. Synthesize and analyse their interaction; 3. Foster dialogue and co-create future options with stakeholders; 4. Collect and consolidate data and produce future projections; 5. Identify policy and governance options for inclusion and equality. GI-NI generates this by: building on state-of-the-art research and other EU projects; using innovative methods; combining EU-wide and international micro- and macro-data; addressing gaps in knowledge and insights on data, joint impacts, and futures. We generate three new outcomes: 1. New scientific understanding of joint impacts of transformations; 2. Multilateral policy solutions; 3. New evidence in support of a robust EU policy strategy. GI-NI carefully disseminates and valorises results.GI-NI addresses the general priorities of the H2020 Work Programme ‘Europe in a changing world’: 1. Address concerns of EU citizens on migration and the 4th Industrial Revolution by better understanding their impact on work, skills and equality and presenting scenarios and solutions; 2.Collaborate with international partners beyond EU borders (China, India, Brazil, Singapore); 3.Contribute to sustainable prosperity by bottom-up firm-level evidence and sol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Reducing required sample size of new studies by effectively using historical data: new methods for evaluating mechanisms, conditions, and alternative explanations'.

assistant: **Innovation**

Scientists, organizations, and governments are moving in the direction of sharing their data. This will lead to an unprecedented amount of available data that researchers could use as prior information in a Bayesian analysis. While Bayesian methods are a promising method for using the growing amount of available information to increase statistical power in research studies, there is a great need for developing guidelines for calibrating existing data to create accurate informative prior distributions.  Bayesian methods that incorporate accurate prior information in the statistical analysis reduce the required sample size of the new study without decreasing the chance of detecting a true effect. However, prior data may be from a different population, measured using different instruments, and/or collected using different experimental procedures than those in the current study. Using the results from a prior study that differs from the current study in any of these respects as prior information in a Bayesian analysis can lead to biased results.Several promising calibration methods have been proposed for linear regression analysis. In this project I will extend and test these methods to models with third variables that reveal the conditions under which an effect exists (moderators), the mechanism through which one variable affects another (mediators), and variables that might explain an observed effect (confounders). I will develop guidelines and tools for social science researchers in numerous fields ranging from psychology and pedagogics to education and epidemiology for proper calibration of data from previous studies when evaluating the conditions under which an effect exists, the mechanism through which one variable affects another, and alternative explanations for an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Safety competition for students', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

An international student safety technology design competition will be organised during the next ESV (Enhanced Safety of Vehicles) conference to be held in Washington DC in June 2005.The final competitors have to be selected within each of the three world r egions: Asia/Pacific, Europe, NorthAmerica. The proposed Specific Support Action SAFECOS 05 is aimed at organising and supporting the technical models designed by European student teams to be presented and selected at the next ESV Conference in June2005.Th e competition will be organised in 3 steps: 1. preselection of the 5 more relevant projects based on their written description (including drawings) 2. construction of models of the 5 selected projects and selection of the 2 best projects according to pre sented models 3. exhibition of the 2 winner models at the ESV Conference. For phases 1 and 2, the jury will be appointed by the EEVC (European Enhanced Vehicle-safety Committee) Steering Committee and, at the same time, a similar procedure will be put in place in North America and in Asia/Pacific.