RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Role of PTP1B in breast cancer' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

In 2006 alone, an estimated 410,000 women will die from breast cancer worldwide. Improved understanding of how breast cancer arises and the factors that determine breast tumour biology are urgently needed to improve treatment options. Tyrosine phosphorylation is a reversible process, mediated by protein-tyrosine kinases and protein-tyrosine phosphatases (PTPs) that regulate critical cell signalling pathways. Abnormal tyrosine phosphorylation underlies various diseases of deregulated growth and differentiation, including cancer.This proposal focuses on the phosphatase PTP1B, an established negative regulator of insulin and leptin signalling that is a leading target of therapy for diabetes and obesity. PTP1B has also been implicated in breast cancer, including as a negative regulator of the receptor tyrosine kinase HER2 signalling. Conversely, PTP1B over-expression is found in 40-70% of human breast cancer and correlates with HER2 positive tumours. Thus, these studies offer contradictory conclusions on whether PTP1B potentiates or antagonizes HER2-mediated transformation in vivo, a question that remains unanswered. My preliminary data reveal that PTP1B ablation protects mice from HER2-evoked mammary cancer. Therefore, PTP1B appears to be a required positive component of HER2-evoked transformation, in contrast with its negative role in other receptor systems.My specific aims include:1. to determine the biochemical and cellular mechanisms underlying the cancer promoting effects of PTP1B on HER2-evoked breast cancer;2. to address whether PTP1B is a suitable target of breast cancer therapy;3. to define the precise pathogenic effect of PTP1B over-expression. Based on my preliminary data, I hypothesize that PTP1B targets key downstream signalling molecules to potentiate HER2-me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The nature of magnetic interactions in strongly correlated elecron systems studied by neutron diffraction' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

In highly correlated electron systems the magnetic interactions lead to the formation of large quasiparticle masses at low temperatures. The aim of this project is to reach a better understanding of the strong electron correlations in heavy-fermion systems (HF) and liquid 3He by studying the magnetic interactions with inelastic neutron scattering. In recent years HF systems have shown a large variety of groundstates with superconductivity, quasi-insulating behaviour and the presence of magnetic instabilities. This large variety of groundstates can not be understood from the existing models. In this project we propose to perform inelastic neutron scattering measurements down to ultralow temperatures and under high pressure in order to study the magnetic interactions of a number of characteristic HF compounds with different groundstates and liquid 3He. The measurements will be performed at the cooperative research group of the Institute Laue Langevin (ILL) and the nuclear centre (CENG) in Grenoble.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development and Application of the 14CO methodology for validating OH distribution, incorporating a stable study of Europe's CO budget', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

To obtain a better insight in regional OH radical and CO sources distribution and seasonality in Europe.Knowledge about distribution and seasonality of the pivotal atmospheric oxidant hydroxyl (OH) is essential to understand tropospheric chemistry, the distribution of reactive trace gases and their rates of removal from the atmosphere. A new and promising methodology for determining OH distribution is emerging. This new method is based on the detection of 14CO in the atmosphere. 14CO is a direct consequence of the interaction of cosmic radiation with the earth's atmosphere. Most neutrons produced eventually lead to 14CO via the nuclear reaction 14N(n,p)14C. The freshly formed 14C is very rapidly oxidized to 14CO. It is the subsequent step of 14CO + OH => 14CO2 + H which allows the assessment of OH, because 14CO production is known and resulting 14CO levels can be measured. Thanks to the recent advances in accelerator mass spectrometry (AMS) the extremely rare 14CO can be detected accurately. It is intended to determine 14CO bimonthly at 5 continental locations for 2 1/2 years starting at the upcoming solar minimum of solar cycle number 22. One additional very important site will be the GAW station at Iza$a, Canary Islands (Spain), being more representative for the remote atmosphere, and lower latitudes. Two experiments are to be integral part of this project. One utilises an elegant very recent development for direct measurement of the actual in situ production of 14CO by cosmic radiation. In this way the source and its modulation are better defined. The other experiment is the development of a time integrating alternative measurement technique. The project will give considerable details about CO in Europe, because next to concentration measurements, the 13C and 18O sta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Network for the development of sustainable approaches for large-scale implementation of sanitation in Africa' to be submitted under Sixth Framework.

assistant: **Abstract**

Without a sharp acceleration in the rate of progress, the world will miss the MDG sanitation target by half a billion people. For instance, in sub-Saharan Africa almost two-thirds of the population (64%) are lacking adequate access to excreta disposal facilities. In African countries the sanitation coverage varies from 84% in urban areas to 45% in rural areas. To achieve the year 2015 goal for urban water supply coverage an additional 210 million (194 in rural areas) people over the next 15 years will have to be provided with service. The proposed Coordination Action, aims to congregate the most relevant stakeholders in the field of sustainable sanitation in the Sub-Saharan African and European frame. NETSSAF will promote international cooperation between re search organisations, associations, universities and social and governmental stakeholders in a European and Sub-Saharan African context, focussed in particular in the West African countries. A sustainable sanitation expert and research co-ordination platform and an expertise network will be established, in order to co-ordinate, assess and guide suitable research and strategic activities with the aim of identifying best practices, gaps in knowledge and barriers to further execution and to propose directions for futures research. The aim of the proposed network will be to develop a variety of innovative, adaptable and replicable approaches to sustainable sanitation, integrating appropriate low cost technologies in the context of community based management and their relevant governance, institutional frameworks and socio-economic constraints. The main outcome will be the development of a Participative Multi-stakeholder Sanitation Management Support Tool aimed for the end-users to be able to apply large scale sanitation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Enhancing the EU's Transboundary Crisis Management Capacities: Strategies for Multi-Level Leadership'.

assistant: **Concept**

The European Union (EU) is facing the daunting prospect of transboundary crises: threats that escalate across national borders and policy domains. EU member states must collaborate to address these crises. EU governance can play a pivotal role in facilitating a joint response. But does the EU have the institutional leadership capacities to deal with transboundary crises? The response to the financial crisis – a textbook example of a transboundary crisis – revealed deep problems with crisis leadership, including conflicting diagnoses, regulatory gaps, unclear political jurisdictions and responsibilities, a lack of problem solving capacity, and blame-shifting. Growing euroscepticism has been directly related to the EU’s role during this transboundary crisis. This project outlines the institutional requirements for effective and legitimate crisis leadership in the face of transboundary crisis. We define crisis leadership as a set of strategic management functions, including the detection of impending threats, the collection and sharing of information, the coordination of partners, and the communication to the public about the crisis and the response. The project analyses the capacities of political leaders in EU institutions and member states to fulfill these leadership functions. It will pinpoint the existing and required capacities to support these functions. It investigates the crisis management capacities of individual political leaders, and EU institutions. It explores the effects of political leadership on the member state level and studies how crisis management capacity is exercised in various policy sectors. The project will result in recommendations for effective and legitimate crisis leadership. It establishes a ‘crisis management capital index’ that allows for a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Join the Researchers' Spirit'.

assistant: **Innovation**

Main objective of our proposal is contributing to the reinforcement of public recognition of researcher as profession. The proposed events are organized on Friday 28.9.2012 in renewed program that consists of experiments, workshops, presentations from various science disciplines, researchers’ rock bands, which red line is promoting importance of researchers as profession for society ...all with festive and fun character. The target audience of proposed events, foreseen in an informal and attractive way, in which whole families can take part in, is the public at large, from youngest one to elder citizens. Intensive awareness campaign, which embraces also each year’s research of change in public perception after 28.9.2012, is important tool for strengthening of public recognition of researchers and to measure the impact of RN activities. All activities proposed aim at offering the public at large an opportunity to directly meet researchers in a relaxed atmosphere, with »European corner« in the heart of every event's location, information on EC care for researchers and EU material and information how young people can become researchers, will be provided by European Commission's Europe Direct Maribor, Slovenian Research Agency and Ministry for Science and Technology. Visitors will participate in interesting experiments, workshops in cooperation with researchers. Also the secondary school pupils that will get highest scores at the regional competition of the research initiative “Youth for Advancement of Maribor” will cooperate as well. They will perform RN12 program, side by side with professional scientists with great opportunity to explore their possibilities of developing the real scientific, researchers’ career with support of European Commission and national funders. Re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Edible Metal-Organic Frameworks for Food Fortification' (EMOFFF), addressing dissemination and exploitation.

assistant: **Impact**

Insufficient intake of iron is one of the most common micronutrient deficiencies, with almost one-third of reproductive-aged women suffering from anaemia. Iron fortification of food products is an important route towards addressing this issue, but it is a notoriously difficult problem as product quality is often strongly compromised. While current strategies succeed in addressing some aspects of this challenge, they are often inadequate from a holistic perspective. Resolving these issues will help address societal challenges related to iron deficiencies, provide personalised nutrition, and support the growing adoption of plant-based diets. The objective of this research program is to explore the novel approach based on functional materials from metal-organic frameworks (MOFs) derived from iron (Fe) and edible plant-derived organic molecules, which can function as safe and bioaccessible by-design colloidal delivery systems. The approach will be based on selecting suitable organic ligands from the family of edible, plant-based polyphenols and acids, and use them in safe concentrations as Fe-based MOFs with pH triggered solubility (i.e. reversal back to the mineral and organic ligand) in the gastrointestinal tract. To achieve this goal, the following specific objectives will be met by developing new edible MOFs, both homogeneous and core-shell morphology, from Fe and plant-derived polyphenols and acids and evaluating their reactivity (e.g. oxidation, discoloration) and bioaccessibility in food products. If successful, this approach will enable the design of high-quality, mineral-enriched, plant-based food products. The proposed research program will lead to an increase in high-impact Research & Innovation output in the field of nutritious and functional food, specifically
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Surface Traffic Alerts Improve Runway Safety' to be submitted under Horizon 2020.

assistant: **Abstract**

As a result of increasingly busy airports, safe runway operation is one of the highest challenges for aviation safety. All main aviation bodies (e.g. IATA, ICAO, CANSO, ACI, EASA, FAA & EUROCONTROL) identify runway incursion as a major safety threat. Safety has been improved thanks to airport surface management systems: A-SMGCS is available on many major airports and ground safety nets (e.g. RWSL) start to be deployed. However, these systems are not expected to fully resolve the runway incursion risk and are not envisaged to be deployed at smaller airports.  Incursion rate remains steady (3/100.000 operations) and events continue to occur (28 near-miss collisions last 5 years).Although TCAS has been in use since 1981, there is currently no aircraft system to prevent runway collisions. Within S2020-W1 PJ03B05, ADS-B technology is leveraged to validate on-board SURFace Alerts with possible Indications (SURF-A & SURF-IA). SURF-A/IA is the ultimate safety net against collision when all previous barriers have failed. Solution is reaching V3 in 2019 thanks to fast-time/real-time simulations and flight test validation.During S2020-W2 VLD2, SURF-A/IA airborne platforms will be developed, certified, fitted on airline aircraft and exposed on revenue flights. The objective is to check the performance of the function in real environment, in particular the absence of nuisance alert. Participating ANSPs (DSNA, DFS, ANS-CR(B4), PANSA (B4)) and EUROCONTROL, who are convinced of the need for complementary aircraft safety net for airport operations, will conduct specific studies to ensure the interoperability with ATC procedures & ground safety nets. In addition, this trial will be the largest ground ADS-B IN trial worldwide, paving the way towards large deployment of SURF-A/IA or future
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Power Density improvement demonstrated on a certified engine'.

assistant: **Objectives**

SMA currently manufacture a 4 cylinder air cooled diesel engine. It will render this product more competitive in the market place if it has a higher power output (+20%) and is lighter (10%). This proposal by Ilmor Engineering Ltd presents a program of work to achieve these objectives.It is proposed to use start of the art analysis techniques and invent solutions for:-a. Cooling the cylinder head.b. Improved strength coupled with simplified assembly and manufacturing of the crankcase.c. Improved layout of the engine with regard to the turbocharger position.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Future Toxicology: Better predicting Toxicant-induced cell fate.'.

assistant: **Concept**

TOXIFATE will help change the paradigm of chemical safety assessment and give the next generation of toxicologists the fundamental knowledge and experimental skills that are required to bring about this change. The safe use of chemicals is essential for global prosperity and human health and this is entirely dependent upon robust toxicology. For practical, scientific and ethical reasons, modern toxicology is moving to computational approaches in which large datasets describing chemical structures and toxicological outcomes are used to predict toxicity. The promise of this approach was recently demonstrated when computational approaches for the first-time outperformed animal testing in predicting human toxicity. Nonetheless, our ability to predict toxicity is poor because our understanding of how chemicals affect cells is still rudimentary.  TOXIFATE will provide intersectoral training to 2 researchers who will build new assays to detect toxicant-induced changes in cells. Multi-disciplinary training will generate unique high-content and transcriptomic data describing cell stress and cell death responses. This multidimensional dataset will be used to develop novel computational approaches to improve toxicity prediction.  TOXIFATE will focus on chemical-induced myotoxicity, a severe and sometimes life-threatening toxicity that is characterized by skeletal muscle breakdown. Although at least 200 drugs and chemicals cause myotoxicity, it is relatively under-investigated and what is learnt here to improve prediction of myotoxicity will also be used to improve prediction of other types of toxicity. TOXIFATE researchers will bridge the gap between state-of-the-art science and chemical hazard and risk assessment and be equipped for career paths in the emerging computational toxi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Surface-enhanced Raman spectroscopy for the reliable analysis of solid-state surfaces'.

assistant: **Objectives**

In many industrial fields, the purity of materials is a key feature and the identification of impurities is crucial. For instance, a quicker detection and allocation of dangerous germs and a closer monitoring of smallest traces of environmental pollutants like nano-plastics lead to a higher safety. Likewise, in the production process of high purity devices like ultraprecise lenses or semiconducting devices contaminations can lead to a change in functionality and understanding its origin is decisive. Our technology offers a new reliability to a powerful method – so-called surface-enhanced Raman spectroscopy or “SERS”. Moreover, with our so-called “SERS-plasters” we enable the application of SERS on solid state surfaces which was up to now not possible, thus opening completely new industrial markets. Our technology is based on ultra-precise nanostructures that enhance the signals of the substances in question up to a billionfold. Our nanostructures consist of a novel material, and are fabricated by a scalable nanostructuring method, that was invented by us and tailored specifically to the material. The combination allows reproducible nanostructures and enables a new reliability in ultrasensitive detection. In the proposed project we will develop an extensive marketing strategy for our SERS-plasters and successfully bring our product to market. In addition, the coaching and mentoring program will sharpen the leadership skills of our CEO and female-founder, Dr. Henriette Maaß, and raise our awareness for gender inequalities in a deep-tech surrounding.


**Keywords:** nanotechnology, surface-enhanced Raman spectroscopy