RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'BioActive Coatings in multi-well cell culture plates' (BIOACTIVECOATINGS), addressing dissemination and exploitation.

assistant: **Impact**

Cell culture is a method used for growing living cells artificially outside their natural environment under controlled conditions. It is used for a large range of applications such as studies of cellular functions, drug discovery, biotechnologies and regenerative medicine. Cell culture in vitro is generally performed on plastic substrates, especially multi-well plates or Petri dishes that are made of polystyrene, a very stiff and synthetic material. This stiff substrate can bias the experimental results and mask cellular responses. These culture conditions contrast drastically with the conditions of the cellular microenvironment in vivo, where the cells are surrounded by a soft extra-cellular matrix (ECM) that provides mechanical and biochemical signals. Bioengineers have recently made developments on hydrogels and surface coatings that better mimic the natural ECM and present: 1) a controlled stiffness in a more physiological range than plastic dishes and 2) active biomolecules (peptides, growth factors) that can target specific receptors and trigger cellular responses. However, to date, there are still very few commercially available alternatives to the traditional plastic plates for high throughput cell culture in more relevant conditions. Hydrogel-coated plates have begun to be developed but lack stability in time and are highly sensitive to hydration.The aim of the BioActiveCoatings project is to bring to the market surface-coated plates with a control over thickness, stiffness and presentation of bioactive molecules (peptide, growth factor). This innovative strategy based on the layer-by-layer assembly of biopolymers will be implemented on multi-well plates, which are compatible with biological assays and optical microscopy. The Lbl-coated multi-well plates will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Urban Observatory for Multi-participatory Enhancement of Health and Wellbeing' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

URBANOME aims at building a common EU Framework for evaluating comprehensively multi-sector policies in urban settings supporting the “Health in all Policies” approach of WHO. In this light the overall objective of URBANOME is to promote urban health, wellbeing and liveability, through systematically integrating health concerns in urban policies and the activities of urban citizens, on the basis of detailed and comprehensive evidence on environmental health determinants, the spatial distribution of these in the city, and the social distribution of their impact among different population groups, accounting for different life styles and behaviours. Integration of health concerns, environmental stressors and social equality in public and private activities help alleviate a wide range of contemporary urban challenges, specifically social cohesion and health inequality, and promote the transition of European cities to sustainable, climate proof, smart and inclusive urban economies.URBANOME brings together the complete set of environmental, social, and functional features of a city in an integrative analytical framework that would facilitate the identification of the main determinants of urban health and wellbeing and support co-creation and testing of policies and precision interventions designed to improve urban health and wellbeing through Urban Living Labs.The URBANOME approach will be applied through pilots built by the Urban Living Labs in Aarhus, Athens, Aberdeen, Madrid, Milan, Ljubljana, Stuttgart, Montpellier and Thessaloniki tackling various levels of environmental exposures, age-dependent susceptibility windows, inter-individual variability, gender differentiation of exposure, and socio-economic disparities. These will allow us to draw conclusions regarding the de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Stakeholder community for once-only principle: Reducing administrative burden for citizens'.

assistant: **Objectives**

Emerging challenges of demographic change and of digitisation of societies call for new innovative models of public governance. Citizens and other civil and private sector actors take a more active and responsive role in ensuring prosperity, a secure living environment and economic growth. Involving citizens in co-creation of public services while reducing administrative burden has become an important social and economic asset in innovative public governance. To significantly reduce administrative burdens, the once-only principle (OOP) demands public administrations to request key data of citizens and businesses only once, and to internally share these data, while respecting data protection and privacy regulations. However, this principle also bears a number of organisational, legal, socio-economic and technical challenges to finally harvest the full benefits and to reach the digital by default status.SCOOP4C will investigate, discuss and disseminate how the OOP can be implemented in public service provisioning in order to significantly reduce administrative burden and simplify administrative procedures for citizens while reusing data among public administration with the control and consent of citizens. In particular, SCOOP4C will (1) build up and sustain a stakeholder community; (2) identify, collect and share existing good practices of once-only implementations for citizens and establish a body of knowledge; (3) discuss challenges, needs and benefits of the OOP in co-creation and public service provisioning contexts involving citizens; (4) develop policy recommendations towards a necessary paradigm change to build trust in the once-only implementations; (5) identify relevant stakeholders and develop a strategic stakeholder engagement plan to ensure sustainable impleme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Sustainable BIObased nanoMAterials Community (BIOMAC)' in the context of a Horizon 2020 call.

assistant: **Objectives**

Recent developments render the biobased sector a key player in European Economy providing a great impetus towards Circular Business Models of resource efficiency. Developments in biobased nanomaterials are coupled with biotechnologies applied to biomass converting the renewable resources into high added-value polymers. BIOMAC will establish an Open Innovation Test Bed (OITB) Ecosystem providing open access to SMEs or Industry to a single-entry point. Starting from the utilization of biomass sources followed by the production of biobased nanoparticles and different building blocks the ecosystem produces biopolymers for the strategic sectors of Food Packaging, Construction, Automotive and Printed Electronics which consist a high market share. A self-sustainable open innovation ecosystem for the upscaling of upscaled processes across the supply and value chain is intended to be created in order fill this gap. Although the last two decades a high number of publications have been only a very limited number of such cases has been finally commercialized and reached the market end users. Some of the reasons that these have not been adopted by the market are lack of investment, funding for further development, upscaling and the limited willingness of end users to adopt nanomaterials into their processes, this is the ‘valley of death’ which BIOMAC intends to overcome. The OITB will offer services that cover the assessment of regulation & safety, sustainability, circularity and market potential among with modeling, process control, standardization and characterization; accessible at fair conditions and cost. BIOMAC establishes a concrete community of open collaboration for stakeholders and customers enabling innovation and minimization of investment risks. This will be achieved by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner'.

assistant: **Innovation**

SCREENED will develop 3 different three-dimensional (3D) in vitro assays based on rodent and human thyroid cell constructs. At different level of anatomical complexity, these assays will increasingly mimic the structure and function of the native thyroid gland, ultimately achieving the replication of its vascular anatomy and morphogenetic characteristics: 1) a 3D organoid based on stem-cell derived thyroid cells, 2) a decellularized scaffold able to reproduce the biological composition of a native thyroid, repopulated by the 3D organoids, and 3) a bioprinted construct with the 3D organoids able to mimic the spatial and geometrical architecture of a native thyroid. These 3D assays will be hosted in a modular microbioreactor equipped with innovative sensing technology and enabling precise control of cell culture conditions. New superparamagnetic biocompatible and biomimetic particles will be used to produce “magnetic cells” to support precise spatiotemporal homing of the cells in the 3D decellularized and bioprinted constructs. The 3D assays will be used to screen the effect of endocrine disruptors (EDs) on the thyroid function in a unique biological sex-specific approach. Their performance will be assessed individually, in comparison with each other, and against in vivo studies. The 3D assays are expected to predict with more sensitivity and specificity the thyroid responses to different classes of EDs at low doses, compared to classical 2D in vitro assays or animal models. Supporting the “Adverse Outcome Pathway” concept, proteogenomics analysis and biological modelling of the underlying mode of action will be used to gain a mechanistic understanding of the chain of events from exposure to adverse effects on thyroid development and function.For future uptake, SCREENED w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Coordinated energy-related PPIs actions for cities (CEPPI)' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

CEPPI aims to build capacity in cities on how to achieve more sustainable energy solutions through a pro-innovation procurement approach (PPI) & to demonstrate this by selectively intervening in scheduled public tenders.   The interventions will involve 5 cities with different economic & political situations & provide the case-based evidence for replication by others.The scale of energy demand in European cities is huge & as an ever greater percentage of citizens are living in urban areas.   Some of the biggest city authorities consume over 1000GWh of energy every year to run their operations & it is estimated that the energy consumption of the whole city (the wider sphere of influence) could be at least 50 times that of the city authorities alone.   Much of the investment in energy efficiency & renewable energy production has been based on project funding & there is an underexploited opportunity to achieve more systematic and progressive improvements through embedding PPI methodologies within the ongoing processes for the procurement of energy-intensive goods & services.   CEPPI will demonstrate, through an action learning process, how forthcoming public tenders can be influenced to achieve a more sustainable energy outcome & build capacity amongst management & procurement professionals.The project will build on established relationships that have been developed between the five participating cities (Birmingham, Budapest, Castellon, Valencia, Wroclaw) through the Climate KIC.   They will be mentored (by leading PPI and sustainable energy experts) through an action learning process that will build the short term knowledge and PPI capacity to reduce annual energy consumption by at least 33GWh.  Energy & procurement foresight activities will provide the strategic directio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Probing Ultrafast Stereochemical Dynamics by Femtosecond Electronic Circular Dichroism Spectroscopy' (CHIRALSCOPY) targeting Horizon 2020.

assistant: **Abstract**

Since the structure of a (bio)-molecule is crucially linked to its biochemical functions, following its evolution in the course of a chemical reaction or biological process would allow one to gain fundamental insights into the reaction mechanisms and pathways. This calls for optical spectroscopy techniques capable of recording structural dynamics with high time resolution, down to the femtosecond regime. Circular dichroism (CD), i.e. the difference in absorption of left- and right-handed circularly polarised light, is a sensitive probe of the structure of chiral molecules. CHIRALSCOPY aims to develop an innovative time-resolved CD spectrometer which combines the structural sensitivity of steady-state CD spectroscopy with the high time resolution of ultrafast nonlinear optical spectroscopy. CHIRALSCOPY will adopt an innovative approach which directly measures in the time domain the chiral light field from a molecule by combining interferometric detection with optical heterodyne amplification. The state-of-the-art time-resolved CD instrument will be used to elucidate structural dynamics during a prototypical biochemical reaction. CHIRALSCOPY will equip the Experienced Researcher with new knowledge and skills in advanced optical technologies and biophysics, thus broadening his scientific background and enhancing his prospects as an independent researcher. At the same time, the Action and the Host Institution will benefit from the advanced knowledge in ultrafast spectroscopy acquired by Researcher during his PhD thesis. CHIRALSCOPY promises to open new vistas in the field of ultrafast optical spectroscopy enabling one to interrogate molecular dynamics with femtosecond temporal resolution and exquisite structural sensitivity−thus realising the chemist’s dream of a capturing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The basis of morphogenetic competence in tomato development: a role for Trifoliate' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The diversity of plant architecture is mainly determined by the shoot branching patterns and leaf forms. Factors involved in either of the two processes have been identified in Solanum lycopersicum (tomato). However, it has been recently demonstrated that some of the genetic modules regulating formation of axillary meristems, from which branches develop, affect also leaf dissection. Yet it is not clear how these modules interact and contribute to both developmental mechanisms.The aim of this project is to obtain a fundamental genetic and molecular understanding of a common mechanism regulating shoot branching and leaf dissection in tomato. This will be done by an in-depth analysis of these two developmental processes that are regulated by the Trifoliate gene.Using high-throughput next-generation DNA sequencing coupled with traditional molecular approaches, I will identify genes acting in both processes, which are potentially direct targets of Trifoliate. Subsequently, I will monitor the expression patterns and expression levels of selected candidate genes at different stages of axillary meristem and leaf development. Finally, the functionality of these genes will be tested in the corresponding mutants and overexpression lines as well as by use of transcriptional reporters. This proposed work will help to elucidate general concepts underlying cell competency in the development of tomato.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Prostate Research Organizations-Network of Early Stage Training'.

assistant: **Concept**

New and recent developments have revolutionized the prostate cancer research and clinical arenas, requiring the next generation scientists to have comprehensive knowledge and expertise in basic, clinical and applied research. PRO-NEST offers young researchers a European integrated, multi-disciplinary training programme to become an independent and all-round scientist and team leader in (prostate) cancer research. This network is driven by recognised and experienced scientists from 17 academic and industrial partners. The joint PRO-NEST research programme focuses on the understanding of the molecular events responsible for the initiation and progression of prostate cancer as well as on the development of novel biomarkers and therapeutic targets, with the ultimate goal to improve the diagnosis, prognosis, treatment and prevention of this major European health problem. The fellows will strongly contribute to this programme by their individual research projects that will be carried out in a high standard and collaborative scientific infrastructure under the supervision of experts in the field. In this way, they will become technical specialists in a dedicated area of cancer research. The scientific and complementary skills of the fellows will be expanded and deepened by secondments and by theoretical and practical network-wide training courses on basic and clinical aspects of prostate cancer, biomarkers, technology, valorisation, scientific writing and presentation, project management, communication skills and job application skills. In an international conference entitled ‘The European prostate cancer research floor on stage’ organised at the end of PRO-NEST, the fellows are given the opportunity to present themselves to potential coming academic and industrial employers.T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Early changes in gene expression following virus infection in plants' under Fourth Framework.

assistant: **Concept**

The proposed work is based on the observation of transient induction of high levels of expression of heat shock protein 70 kD (HSP70) mRNA following pea seed borne mosaic virus (PSbMV) invasion of pea tissues (M. Aranda, unpublished results). This is a completely new observation in plant virology and provides the unique opportunity to obtain training in new areas of molecular biology that will be invaluable in establishing a research career in Spain. The goals of the proposed project are: 1) to explore the potential of Saccharomizes cerevisiae as a model synchronous system for the dissection of the molecular basis for the HSP70 response to viral infection, and 2) to study the induction of HSP70 by viral infection with regard to the nature of the viral inducer and the complexity of signalling pathway between inducer and induction. The work will use an innovative approach and technology which is very new but already in use at the host institution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Hypoxia/ischemia and dynamic changes in neuronal morphology and function' (1998-2002).

assistant: **Concept**

Metabolic stress is associated with a number of neurological disorders. The proposal will investigate novel aspects of cell signalling that underlie changes in neuronal function associated with periods of hypoxia/ischemia, such as the relationship between calcium homeostasis, morphological changes and glutamate receptor subunit expression.