RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multi-scale, Multi-physics MOdelling and COmputation of magneto-sensitive POLYmeric materials' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

MOCOPOLY is a careful revision of an AdG2010-proposal that was evaluated above the quality threshold in steps1&2. In the meantime the applicant has made further considerable progress related to the topics of MOCOPOLY. Magneto-sensitive polymers (elastomers) are novel smart materials composed of a rubber-like matrix filled with magneto-active particles. The non-linear elastic characteristics of the matrix combined with the magnetic properties of the particles allow these compounds to deform dramatically in response to relatively low external magnetic fields. The rapid response, the high level of deformations achievable, and the possibility to control these deformations by adjusting the external magnetic field, make these materials of special interest for the novel design of actuators for a fascinating variety of technological applications. It is the overall objective of this proposal to uncover the process-microstructure-properties relations of the emerging novel multi-scale, multi-physics material class of magneto-sensitive polymers with the aim to better exploit its promising potential for future, currently unimagined technological applications. This objective will only be achieved by performing integrated multi-disciplinary research in fabrication, characterisation, modelling, simulation, testing and parameter identification. This proposal therefore sets up a work programme consisting of nine strongly interconnected work packages that are devoted to 1) fabrication of magneto-sensitive polymers, 2) microstructure characterisation by modelling and simulation, 3) microstructure characterisation by CT-scanning, 4) continuum physics modelling at the micro-scale, 5) computational multi-physics homogenisation, 6) continuum physics modelling at the macro-scale, 7) testing at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Smart polyurethane alloys for components having electrical and thermal functional gradients' under Fourth Framework.

assistant: **Concept**

Expected deliverables were:- Brand of polyurethane susceptible to be developed;- Brand/s of powders which are capable to make the above mentioned brand of polyurethane conductive (that is to say, lowering resistivity from 1012 Ohm-cm to 105-104 Ohm-cm).Experimental injection system implementing the injection process with doped powders, as well as the system for properly disposing the powders over a predefined 2D or 3D pattern (functional gradient process).Industrial workpieces injected and doped through the above mentioned process, and showing the above mentioned conductivity performances in the doped sections of the pattern, using them for practical applications.All the above mentioned expected deliverables have been achieved, and more. In particular:- The resistivity has been lowered down to 103 Ohm-cm, in industrial workpieces, and down to 100 Ohm-cm in test samples, thus opening up further industrial exploitation possibilities (EMI screening) than initially envisioned;- Alternative techniques, such as carbon-fiber doping, have been investigated.Objectives and content The utilisation of plastic materials in industrial manufacts has been experimenting a very sharp growth in the last decades. This is true, in general, for all kinds of plastic materials, which have seen their fields of application gradually increased from simple, consumeroriented objects up to large and complex workpieces, with elevate structural characteristics of mechanical and thermal resistance. One typology of manufacts, however, has so far been unable to fully profit of the large-scale of plastic materials, this typology is, in general, constituted by all the manufacts and workpieces requiring high electrical and/or thermal conductivity, in order to perform their functional role. This makes the ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Organocatalytic enantioselective dearomative photocycloadditions for the synthesis of polycyclic heterocycles' (PHOTO-STEREO), addressing dissemination and exploitation.

assistant: **Impact**

The PHOTO-STEREO action provides a general synthetic platform for the organocatalytic enantioselective dearomatization of heteroaromatic compounds by means of [2+2] photocycloadditions to obtain complex saturated polycyclic compounds in one step under mild conditions. The proposed strategy relies on the direct excitation, by means of visible light, of organocatalytic heteroaromatic intermediates to access their excited state reactivity. Furthermore, the implementation of this methodology into a flow system will enable the collaboration of the host institution with an industrial partner, offering to the fellow a valuable experience of the dynamics in industrial R&D. PHOTO-STEREO will merge the expertise of the group of Prof. Dell’Amico in photoredox catalysis with the expertise of the fellow in asymmetric organocatalysis. Overall, this project promotes the efficient use of sustainable resources, such as light and inexpensive heterocyclic feedstocks, while bringing innovation into the fields of synthetic organic chemistry and medicinal chemistry. This project will ultimately contribute to the EU’s scientific excellence, and at long term, to scientific innovation with a positive impact in the society and EU’s economy. Importantly, all the competences acquired during the realization of this fellowship, together with the creation of new connections with industry and academy, will allow the fellow to reach a position of complete professional maturity, while providing her with fruitful opportunities for gaining a permanent position as senior scientist in both academic, or industrial settings


**Keywords:** Asymmetric synthesis, Organocatalysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'An integrative strategy of testing systems for identification of EDs related to metabolic disorders', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Exposure to chemical substances that can produce endocrine disrupting effects represents one of the most critical public health threats nowadays. In line with the regulatory framework implemented within the European Union to reduce the levels of endocrine disruptors (EDs) for consumers, new and effective methods for ED testing are needed. The OBERON project will build an integrated testing strategy (ITS) to detect EDs-related metabolic disorders by developing, improving and validating a battery of test systems. It will be based on the concept of an integrated approach for testing and assessment (IATA). OBERON will combine 1) experimental methods (in vitro e.g. on 2D and 3D human-derived cells and tissues, and in vivo i.e. in zebrafish at different stages), 2) high throughput omics technologies, 3) epidemiology and human biomonitoring studies and 4) advanced computational models (in silico and systems biology) on functional endpoints related to metabolism. Such interdisciplinary framework will help at deciphering EDs based on mechanistic understanding of toxicity by providing and making available more effective alternative test methods relevant for human health that are in line with regulatory needs. Data generated in OBERON will also allow the development of novel Adverse Outcome Pathways (AOPs). The assays will be pre-validated in order to select the test systems that will show acceptable performance in terms of relevance for the second step of the validation process, i.e. the inter-laboratory validation as ring tests. Therefore, the aim of the OBERON project is to support the OECD conceptual framework for testing and assessment of EDs by developing specific assays not covered by the current tests, and to propose an IATA approach for ED-related metabolic disorders dete
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'URBAN REDEVELOPMENT and SOCIAL POLARISATION IN THE CITY' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The thesis of this research is that large scale urban redevelopment projects promote social exclusion and polarisation. It is examined whether this thesis holds or if, on the contrary, large scale urban redevelopment fosters social integration of citizens into the urban society. As polarisation and exclusion processes are acute in urban environments where 70% of the European population lives, the analysis of the relationship between urban restructuring and social exclusion/integration is an urgent task. Indeed, in the last decade, attempts to strengthen the competitive position in an intensifying globally competitive environment, have transformed the economy and society of cities. The units of analysis are large scale urban (re)development projects (UDPs), which are implemented at the cross-roads of global processes such as global investment flows, dependence on immigrant labour, transnational information flows, value-added networks and super-national decision-making processes. These projects embody trend-breaking epochal changes such as transformations of cultural values and preferences, changes in citizenship regulation and entitlement, informalisation of labour markets and relations, as well as of competitive environments. But at the same time UDPs are decidedly local, capturing the global trends, and incorporating them in a particular local setting. The research project aims at reconstructing the global and local aspects of the UDPs and how they affect the integration/exclusion of citizens in the local economy and society. Four objectives are identified: 1) The analysis of thirteen UDPs in twelve Member States and the factors of social polarisation, exclusion and integration which these projects embody. For this purpose, the dynamics which relate each project to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A NORTH AFRICAN PERSPECTIVE ON MODERN HUMAN ORIGINS' (ATERIAN) under Seventh Framework.

assistant: **Objectives**

The archaeological record of North Africa is becoming increasingly important for several reasons, including the human fossil record and the early evidence of behavioral modernity. The purpose of this proposal is to examine the Aterian lithic industry in the context of modern human origins. In particular, this proposal seeks to point out the assessment and definition of Aterian technocomplex, the role of tanged pieces in this system and the appraisal of paleoenvironmental context. Those data will make possible a technological and cultural comparison with adjacent areas, including Egypt and Levant. So, this proposal aims to re-define Aterian trough a deep and modern oriented lithic analysis and through the application of a technological analytic approach. This kind of analysis proposes to integrate traditional typological definitions with technological, morphometrical, statistical one, related to use wear approaches. The typological characteristics of Aterian lithic assemblages have been better explored than their technological aspects until now. In fact, the analysis of Aterian has tended to focus almost exclusively on the presence or absence of tanged pieces, the only tools being recognized as uniquely Aterian. This project seeks to put this lithic industry in the larger context of the technological system devoted to blank production. The analysis of the Aterian lithic industries from Jebel Gharbi, issued from the Italian-Libyan Archaeological Project, will be the starting point to reach objectives. Lithic collections are partially conserved in Italy (in the Museo delle Origini of La Sapienza University) and partially in Libya (Department of Antiquities, Tripoli). Moreover, new Aterian evidence will be collected during planned field season 2009 and 2010 in Jebel Gharbi.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Organisation of International Science Week and Festival Science is Fun '2005" and Dissemination Actions'"' to be submitted under Sixth Framework.

assistant: **Abstract**

The region of Lodz is among the biggest agglomerations in Poland with the population of approximately 1 million inhabitants. The project (duration: 5 months) will consist of 3 stages: promotion actions, an International Science Week and Festival Science is Fun '2005" (5 days) as well as promotion and dissemination actions which will be held in Lodz. Organization of these events has three major objectives: to promote science and scientific career among students and young people, to improve the understa nding of the contribution that science makes to the society, to promote the European Union as an ideal place for scientific careers. Science Week and Festival will include different actions engaging students, inhabitants and public authorities of Lodz, y oung people with their parents and entrepreneurs. There will be numerous forums debates devoted to the opportunities to pursuit scientific career in Europe, the impact of science on daily life of citizens, job creation and region development with a view to integrate scientists and business people. The festival events will include theatre and music performances, exhibitions and excursions. Promotion and dissemination actions will include presentations for young people in schools and for students in unive rsities, TV documentaries and radio broadcasts in media, advertisement of science and R&D sector in newspapers, creation of the website for the Project as well as printing materials. There will also be anecdotes on science, short biographies of worl d-famous scientists and short presentations on the contribution of science to daily life of citizens of Europe to attract attention. The activities of Project will be monitored using questionnaires. The Lodz Region is lregion faced to economic difficulti es with a numerous popul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Scalable Software Services for Life Science' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Life Science is developing into one of the largest e- Infrastructure users in Europe, in part due to the ever-growing amount of biological data. Modern drug design typically includes both sequence bioinformatics, in silico virtual screening, and free energy calculations, e.g. of drug binding. This development will accelerate tremendously, and puts high demands on simulation software and support services. e-Infrastructure projects such as PRACE/DEISA have made important advances on hardware and scalability, but have largely been focused on theoretical scalability for large systems, while typical life science applications rather concern small-to-medium size molecules. Here, we propose to address this with by implementing new techniques for efficient small-system parallelization combined with throughput and ensemble computing to enable the life science community to exploit the largest next-generation e-Infrastructures. We will also build a new cross-disciplinary Competence Network for all of life science, to position Europe as the world-leading community for development and maintenance of this software e-Infrastructure.Specifically, we will (1) develop new hierarchical parallelization approaches explicitly based on ensemble and high-throughput computing for new multi-core and streaming/GPU architectures, and establish open software standards for data storage and exchange,(2) implement, document, and maintain such techniques in pilot European open-source codes such as the widely used GROMACS & DALTON, a new application for ensemble simulation (DISCRETE), and large-scale bioinformatics protein annotation,(3) create a Competence Centre for scalable life science software to strengthen Europe as a major software provider and to enable the community to exploit e-Infrastructures
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New opportunities for altimetry in hydrology' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The objective of N.O.A.H. is to demonstrate that the use of Earth Observation (EO) data provides a significant improvement in the field of hydrology and hydraulics, and particularly for flood prevention. Earth observation techniques enable us to measure terrain relief from space. These techniques include interferometry, which is based on ERS SAR data, and-optical stereoscopy, which uses SPOT imagery. Data obtained through such processing techniques give access to precise and comprehensive information on the terrain characteristics, on a regional level (5 to 10 meters precision): relief, catchment basins, and slopes. Earth observation also provides adequate information on land use. EO data and derived high-level product information will be integrated into hydrological and hydraulic models over a pilot area (The Moselle Basin) to better understand the issues involved in the management of land use with respect to the risk of flooding, and to better serve user needs in this domain. The first year of the project will be devoted to the collection and the analysis of user requirements, the generation of suitable high-level products derived from EO data, and the development of tools to integrate this data into hydrological and hydraulic models. The second year will involve the implementation of the models with the full integration of the EO data gathered, the generation of the flood-related outputs (e.g. risk maps), and a final assessment of the results from a commercial, technical and scientific viewpoint. Finally, N.O.A.H. will include communication activities in interaction with the CEO services, to develop awareness of the contribution of EO data in the domain of flood prevention. The N.O.A.H. project responds to an urgent need in Europe concerning the prevention of flood e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ECM and TFEB interplay: from building multidisciplinary devices to unravelling the missing link in cancer', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Over the last 30 years, researchers have shown that tumor cells not only need to accumulate oncogenic genetic alterations, but also rely on permissive cues from a surrounding extracellular matrix (ECM) for malignant progression. However, reconstructing the tumor niche in vitro has not been easy due to the complexity of its intertwined physico- biochemical properties and the limitation of the available biomimetic scaffolds. Furthermore, preclinical studies have mainly focused on druggable targets at the intracellular signaling level and overlooked the implication of the ECM. To overcome these hurdles, we will unravel the ECM mechano-chemical contribution in tumorigenesis and its continuum interaction with tumor cells in 3 steps. First, we will deconstruct bladder cancer ECM through in-depth analysis of its physical and biochemical features. This will provide us a blueprint to follow, in order to build a tailored microenvironment for bladder tumoroids. Then, we will reassemble ECM properties in a new generation of tunable materials, functionalized with ECM proteins secreted by bladder cancer cells in vitro. Using our developed tumoroid model, we will finally chart the reciprocal crosstalk between extracellular cues and transcription factor EB (TFEB), an emerging oncogene and regulator of tumor microenvironment. By bridging the gap between ECM and TFEB regulation, we anticipate to catalyse the success of cancer prevention and therapy leveraging new druggable targets at the level of the reciprocal feedback between the evolving ECM and tumor cells.


**Keywords:** ECM, Tumoroids, TFEB, microfluidics, Precision medicine