RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Preventing lifetime obesity by early risk-factor identification, prognosis and intervention' in the context of a Horizon Europe call.

assistant: **Objectives**

Obesity is one of the main population health threats worldwide, with a sustained increase in prevalence over the last decades and a constellation of co-morbidities that seriously hamper individual wellbeing and life-expectancy. Despite major research efforts, obesity treatments have proven of limited efficacy. Thus, effective prevention strategies are essential to avoid the full spectrum of metabolic complications of overweight during the life-course.Adult obesity is rooted on early maturational events, including pathophysiological and psychological determinants occurring during the gestational, infantile and/or adolescent periods, which globally remain ill defined. Identification of such early pathogenic mechanisms and markers of metabolic disease is key for active prevention and personalized management of body weight disorders later in life. Of note, pathogenic mechanisms and susceptibility to obesity are seemingly gender-dependent, but this aspect remains underexplored and may compromise effectiveness of preventive measures and treatments tackling obesity and its complications. eprObes (for early Prevention of Obesity) is a multidisciplinary, patient-centered project, involving clinical studies targeting different maturational windows, coupled with cognitive, mental health, life-style and behavioral studies, as well as mechanistic analyses in suitable preclinical models, whose major aim is to define effective strategies for active prevention of obesity during the life-course, with particular focus on early developmental events, from prenatal (including peri-conceptional) to pubertal periods, and determinants of feeding behaviors. Multi-omics studies and integral analysis of eprObes data, assisted by bioinformatic technologies and artificial intelligence, will permit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Transcribed-Ultraconserved Regions as novel biomarkers and therapeutic targets in liver cancer' (LIVERNCODE), addressing dissemination and exploitation.

assistant: **Impact**

Hepatocellular carcinoma (HCC) is the sixth most common malignancy in the world. In Scotland incidence of liver cancer has increased of 60% in men from 2000 to 2010. The outcome of patients with advanced HCC remains poor. Thus, novel therapeutic approaches based on targeting oncogenic driver pathways in HCC are urgently needed, as well as informative prognostic markers that guide the use of existing and novel therapeutic strategies. Non-coding-RNAs (ncRNA) are implicated in liver carcinogenesis. Sequence conservation across species has been postulated to indicate that a given ncRNA may have a cellular function. A genome-wide survey identified 481 genomic sequences that showed 100% identity across the human, mouse and rat genomes. These ultra-conserved regions (UCR) are transcribed as ultraconserved ncRNAs (T-UCR). As they are so finely conserved we hypothesize they may have an essential role in regulating cell homeostasis and that may give rise to cancer when are aberrantly modified. In these studies we will profile the expression of T-UCR in human HCC tissues and in mouse HCC models that have genetic abnormalities similar to those found in human HCC to select the best candidate T-UCRs with a role in HCC pathogenesis and progression. In vitro analyses will be performed to characterize the transcript of T-UCR and assess the mechanism of action. We will evaluate the prognostic value of selected T-UCR by retrospectively and prospectively assessing their expression in a series of human HCC from patients who underwent radical resection or liver transplantation, in order to assess whether their expression may predict tumour recurrence. As we have in vitro data on the efficacy of anti-T-UCR, we propose to study if therapies based on the silencing of T-UCR may prevent tumour fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Landing Gear Advanced Research' in the context of a Fourth Framework call.

assistant: **Objectives**

Objectives and content As a key part of the European Aeronautics Industry, the success of European Landing Gear manufacturers is highly dependent upon the development and exploitation of advanced technologies which improve competitiveness and global market share. The growing diversity of technologies demanded to satisfy future performance and commercial requirements can best be addressed by bringing together specific technological expertise in a European research collaboration. The objective of the proposed research is to position the European Landing Gear manufacturers to capture 50% of the potential 12 BECU market for landing gear over the next 20 years. The market drivers are to reduce, by 25%, system weight, first cost and cost of ownership of landing gear systems. To meet these targets, the technical challenges to be addressed are advanced load control systems; carbon fibre composite actuators; new approach for landing gear design. Within the area of advanced load control systems, the benefits of an active shock absorber control system and of new design concepts in multi-wheel configurations of landing gear systems will be determined through practical demonstration and through evaluation of their implications for the whole aircraft assessed through theoretical analysis. An evaluation of power demand and possible optimisation will also be conducted. For carbon fibre composite actuators, the integrity of two design and manufacture processes will be demonstrated and potential further application of composite materials in the design of light weight landing gear structural elements will be investigated. In the new approach for landing gear design, the theoretical models used in ELGAR I will be enhanced to cover all operating modes of the aircraft and to better represent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Educational Robotics for STEM' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Many children lose their natural curiosity for how things function and interrelate to each other along the way into their lives as young adults. The Educational Robotics for STEM (ER4STEM) project aims to turn curious young children into young adults passionate about science and technology with a hands-on use case: robotics. The domain of robotics represents a multidisciplinary and highly innovative field encompassing physics, maths, informatics and even industrial design as well as social sciences. Moreover, due to various application domains, teamwork, creativity and entrepreneurial skills are required for the design, programming and innovative exploitation of robots and robotic services. Children are fascinated by such autonomous machines. This fascination and the variety of fields and topics covered make robotics a powerful idea to engage with. Young girls as well as boys can easily connect robots to their personal interests and share their ideas through these tangible artefacts. ER4STEM will refine, unify and enhance current European approaches to STEM education through robotics in one open operational and conceptual framework. The concept is founded on three important pillars of constructionism: 1. engaging with powerful ideas, 2. building on personal interests, and 3. learning through making (or presenting ideas with tangible artefacts). The ER4STEM framework will coherently offer students aged 7 to 18 as well as their educators different perspectives and approaches to find their interests and strengths in robotics to pursue STEM careers through robotics and semi-autonomous smart devices. At the same time students will learn about technology (e.g. circuits), about a domain (e.g. math) and acquire skills (e.g. collaborating, coding). Innovative approaches will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of genomic tools for assessing nutrition, growth and reproduction issues in farmed crustacean species' in the context of a Seventh Framework call.

assistant: **Objectives**

The overall aim of this joint exchange programme is to establish a long term bilateral network (Europe & Australia) of researchers active in functional genomics in crustacean aquaculture, strengthen research capacity through exchange of knowledge and expertise in this area, and develop integrated approaches to investigate the main metabolic processes to improve crustacean production due to its high demand and decrease of fisheries captures. The joint exchange programme will involve four partners and will be realised through a series of secondments and face-to-face meetings of staff and PhD students. Training will include Next Generation Sequencing, bioinformatics and gene knockout. The main research objective of the project is to develop transcriptomic markers that provide predictive tools for assessing species-specific nutritional requirements that optimise reproductive and growth performance. This goal includes developing a comprehensive understanding of gender-tailored nutritional requirements in each target species that maximize growth performance of monosex cohorts and that optimise broodstock performance. Comparative and integrative approaches to delineating and refining the specific nutritional requirements for specific target taxa will assist development of the crustacean aquaculture industry (this is relevant to both reproductive and growth-related traits). To reach the main research objective of the project we need to assess and characterize genes and pathways involved in nutrition, growth and reproduction differentially expressed between males and females in order to improve the production of decapod crustaceans in captivity. Then, the final objective of the project is to select the main representative genes related to nutrition, growth, and reproduction or s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Zero waste Heat vessel towards relevant ENergy savings also thanks to IT technologies' (ZHENIT), addressing dissemination and exploitation.

assistant: **Impact**

ZHENIT overall objective is to promote Waste Heat Recovery (WHR) as key and “ready-to-implement” solutions to achieve 2030 IMO/EU targets for shipping sector decarbonization. ZHENIT goal is to fully untap “on-board WH potential” developing and validating WHR solutions at different temperature levels towards the exploitation of WH for different on-board services (cooling, power, desalination)  thus able to valorise heat in different vessel processes like:  WH-to-Trigeneration via an innovative recuperated ORC integrated with an heat pumpt with ejector (T>100°C – NTUA); WH-to-Cooling and Desalination via an adsorption system (70<T<100°C – SORPTION/ITAE); WH-to-Mechanical Work (e.g. for fuel compression) via an isobaric expansion (IE) engine (T<100°C – TECNALIA/ENT).  A validation campaign (TRL5) will showcase how WH-to-X if properly integrated with Digital Solutions (energy monitoring and optimized management – SIGLA, KYMA) and wind hybrid propulsion (wingsail by BOUND4BLUE) can bring to a 25% reduction of vessel energy consumption. Validation results will drive a replication roadmap (at regulatory and economic level) towards 2027-2030 marketability of ZHENIT solutions also thanks to realization of replication feasibility studies via modelling tools and approaches already exploited for terrestrial application. The ambitious goal is to integrate all WH-to-X solutions towards a zero WH vessel. The project is driven by a consortium of 13 partners from 6 countries composed by innovative SMEs and excellent R&D Centres (expert in both WHR systems and sustainable shipping) and coordinated by an innovation oriented engineering company (RINA-C), one of the most important EU naval classification body with a deep expertise in sustainable shipping and with a track record of multi-dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'TRANSPARENT APPLICATION DEPLOYMENT IN A SECURE, ACCELERATED AND COGNITIVE CLOUD CONTINUUM' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

SERRANO’s overall ambition is to introduce a novel ecosystem of cloud-based technologies, spanning from specialized hardware resources up to software toolsets. This will enable application-specific service instantiation and optimal customizations based on the workloads to be processed, in a holistic manner, thus supporting highly demanding, dynamic and security-critical applications. SERRANO is not only tuned and fully aligned with current trends in the cloud computing sector towards the expansion of cloud infrastructures so as to efficiently integrate edge resources, but it also integrates transparently HPC resources ir to provide an infrastructure that goes beyond the scope of the “normal” cloud and realizes a true computing continuum. SERRANO introduces an abstraction layer that transforms the distributed edge, cloud and HPC resources into a single borderless infrastructure, while it also facilitates their automated and cognitive orchestration. It proposes the introduction and evolution of novel key concepts and approaches that aim to close existing technology gaps, towards the realization of advanced infrastructures, able to meet the stringent requirements of future applications and services. It will develop technologies and mechanisms related to security and privacy in distributed computing and storage infrastructures, hardware and software acceleration on cloud and edge, cognitive resource orchestration, dynamic data movement and task offloading between edge/cloud/HPC, transparent application deployment, energy-efficiency and real-time and zero-touch adaptability. Finally, to highlight the proposed ecosystem’s scientific and technological significance, SERRANO will demonstrate three high impact use cases related to (i) secure cloud and edge storage over a diversit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Process improvement by change of paradigm in an agriculture company' (FLOWERPOWER).

assistant: **Innovation**

The main business of Irsslinger is to produce, buy and sell pot-plants. Customers are flower shops home depots and supermarkets in Germany and several European countries. Due to rapid international organisational changes and to increasing external influences (VAT problems with EC customers, increased orientation towards graphical user interfaces of third party software, growing customer and supplier requirements, ascertaining the market position) new developments updates and upgrades of our warehouse system grow with such magnitudes that we are facing ever-increasing problems. The disadvantages of our current software development process confront us with tasks that are nearly impossible to handle.The overall objective of the experiment is to introduce, test and evaluate strict development guidelines, standardisation rules and object oriented methods (Object modelling technique", J. Rumbaugh) and tools, to restructure and improve our software engineering process. An automatic increase of the stability and reliability of the developed software is expected, as well as a general improvement of the development efficiency and speeding up of development times.THE EXPERIMENTTo realise the objectives above, a portion of the Irsslinger warehouse system, the purchasing module is considered for experiment.3 out of 6 software developers (Irsslinger employs 110 people) are involved in the experiment. Following a well defined workplan, they will first be trained on the basics of object oriented technology. Further on, there will be a practical part to increase the quality of the developers. After this, the purchasing module will be re-engineered and redesigned. The redesigned model will be fed into a data dictionary. Based on this data model, the application model will be designed and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mediterranean Science, Policy, Research & Innovation Gateway' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The main aim of the Project is to contribute to the quality of the Euro-Mediterranean research area, with a particular focus on the bi-regional Euro-Mediterranean S&T cooperation, research & innovation, policy dialogue and cooperation monitoring. The proposal aims at tackling the key issues and policy objectives outlined in the Work Programme by creating a dialogue and coordination platform of governmental institutions, research organizations, associations and NGOs helping integrate society in the institutional dialogue. To this end, the Project foresees a comprehensive analysis of selected societal challenges and will address capacity building to increase research capacity, shared knowledge and cooperation. It will also support synergies and networking to strengthen joint activities and EU- MS-MPCs cooperation in EU programmes, as well as a monitoring of regional RTD cooperation and policies. In particular, the proposal is structured to address three societal challenges: energy, high quality affordable food, scarcity of resources. These challenges have been selected on the basis of the result of the long-standing and ongoing EU-MPCs policy dialogue and represent the most significant areas of common interest in current Euro-Mediterranean cooperation. The specific objectives of the Project are thus: enhancing EU-MPCs co-ownership in research cooperation; creating synergies in order to reduce fragmentation of research actions; involving the civil society in the institutional dialogue on research and innovation; developing cooperation instruments to tackle societal challenges with a view to sustainability; supporting research and innovation capacity building through comprehensive training and contributing build an Euro-Mediterranean shared knowledge space in order to devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Reliable Electromechanical actuator for PRImary SurfacE with health monitoring' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The REPRISE project responds to the call JTI-CS2-2015-CFP02-SYS-03-01. The objective of the project is the design and development of an innovative electromechanical actuation system with health monitoring for primary-control-surface of a small aircraft. It is well-known that the electromechanical actuation will lead to weight saving and life-cycle cost reduction but some critical issues of this technology need to be addressed. The REPRISE project will thus be focused on overcoming these issues and improving technology performance, reliability and safety using new technologies and health-management algorithms.Project activities will start testing an available EMA (electromechanical actuator) and ECU (electronic control unit), which meets in general the requirements reported in the CfP, on an available test rig until mechanical failures occur. These tests will allow the development of a Health Monitoring System (HMS) able to detect degradations of the mechanical components before they will evolve into failures. New sensors will be added, to those already embedded into the available EMA, to verify their capability to detect part degradation. The EMA will be then redesigned in order to improve reliability and reduce weight and envelope through the introduction of new technologies into EMA/ECU, new sensors and the HMS. Finally, the improved EMA and ECU will be tested to demonstrate both performances and effectiveness of HMS.Pointing at the success of the project, the REPRISE consortium strength lies in the association of different expertise, from different type of active members (SME, academia and industry). This association will benefit to all involved partners by sharing resources, skills and competencies on a high technological field with a major growth potential. From a