RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Proof of concept of prognostic test for critical Septic Patients based in Early Detection of NLRP3 Inflammasome impairment activation.' (SPEDI-TEST) under Horizon 2020.

assistant: **Objectives**

Sepsis remains the leading cause of death in critical care units of Hospitals, affecting more that 18 million people worldwide and causes a systemic inflammatory response driven by the production of proinflammatory cytokines. Several studies have been conducted to find out whether data mining and machine learning could be used to identify patients at risk of sepsis. Although the currently available biomarkers can help shorten this decision process, there is still a need for additional early disease biomarkers that could anticipate the decision-making identifying immunocompromised septic patients. In this sense, ongoing efforts in the development of a point-of-care testing kit, enabling quick and reliable detection of immunocompromised patients by using blood biomarkers, will aid greatly the early prognosis of sepsis. In this scenario, the prognosis and therapy selection still remains a clinical decision by assessing the patient’s history, symptoms of infection, and development of acute organ dysfunction. Our group have determined under the ERC consolidator grant ref. 614578 (DangerATP) that during the initial 24 h of the inflammatory response in sepsis, monocytes from human septic patients present an early impairment of the activation of the NLRP3 inflammasome that is associated with higher late mortality. This group of septic patients was not identified with any of the clinical or biochemical determinations performed. We have developed an in vitro prognostic (IVD) product for the fast detection in less than 4 hours of early impairment of the NLRP3 inflammasome activation, as a biomarker for the prognosis in sepsis. This IVD will be used in intensive care units and immunology units of hospitals. The objective of the action is to demonstrate the technical and commercial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Institutional Development of Applied Nanoelectromagnetics:Belarus in ERA Widening' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The project aims at reinforcing RTD and cooperation capacities of the Institute for Nuclear Problems of Belarusian State University in the area of applied nanoelectromagnetics. This new research discipline comprising the classical electrodynamics of microwaves and present-day concepts of condensed matter physics is covered by the FP7 Theme 4 'Nanosciences, Nanotechnologies, Materials and new Production Technologies – NMP'. INP BSU is the founder and leading research center in Belarus in this area.  Within the project a set of complementary networking and training activities is foreseen with a strong involvement of already existing and new partners from EU member states and associated countries. Besides, based on research results and their applications in material sciences and medicine, and also taking in consideration the emerging socio-economic needs in Belarus and EU, a strategy of the INP BSU further development will be proposed. All together, the activities will support national RTD in applied nanoelectromagnetics, contribute to young researchers’ career development, intensify information and experience exchange between Belarus and EU teams thus contributing to creation of the European research network in applied nanoelectromagnetics, as far as increase visibility of INP BSU in the European Research Area and its participation in the FP7. Also, the strategy developed for INP BSU will be proposed and disseminated as a model for the integration of the other Belarus teams into European Research Area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'TOWARDS IMPROVED ASSESSMENT OF SAFETY PERFORMANCE FOR LONG-TERM OPERATION OF NUCLEAR CIVIL ENGINEERING STRUCTURES' in the context of a Horizon 2020 call.

assistant: **Objectives**

The purpose of ACES is to advance the assessment of safety performance of safety-critical concrete infrastructure by addressing remaining scientific and technology gaps for the safe and LTO of NPPs. This collaborative project aims to clarify, enhance and unify methods of structural integrity assessment in support of LTO.The project scope of work focuses mainly on safety critical reinforced and prestressed concrete structures. ACES is aimed at an experimental proof of concepts, and validates the developed methodologies at both a laboratory scale and a quasi-full scale level (mock-ups). The proper understanding of deterioration and ageing mechanisms requires a research strategy based on combined experimental and theoretical studies following a multidisciplinary approach, utilizing state of the art experimental and modelling techniques. Material characterization at different length scales is necessary, focusing on the physical understanding of the degradation processes (e.g. radiation effects, internal swelling reactions, liner corrosion, etc.) and their influence on macroscopic mechanical properties and structural/functional integrity of the components.  ACES aims at having a significant impact on the safety of operational Gen II and III NPPs, and impact the design of next-generation plants. ACES will improve the understanding of ageing and deterioration of concrete, and will demonstrate and quantify inherent safety margins introduced by the conservative approaches used during design and defined by codes and standards employed throughout the life of the plant. The outcomes from ACES will therefore support the LTO of NPPs. This will be achieved by using more advanced and realistic scientific methods to assess the integrity of NPP concrete infrastructure. The project will p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Co-ordination action for autonomous desalination units based on renewable energy systems'.

assistant: **Innovation**

The Coordination Action ADU-RES will achieve two main objectives: 1)Further development of integrated plant designs for mature and cost efficient autonomous desalination units (ADUs) which are based on renewable energy sources (RES) 2)Formulation of poli tical strategies for boosting ADU-RES implementation within the existing political and legislative frameworks in the Mediterranean 1)R&D units of autonomous desalination units with a capacity below 50 m3 per day which are based on RES are operating su ccessfully under the supervision of water and research institutes. Still, commercial applications remain rare. Now is the time to strengthen and unite research work for the design of robust and cost-effective desalination plants that operate autonomously on RES. Remaining S&T challenges are: Radical cost reduction Advanced management and control system Improved long-term reliability Environmentally sound set-ups 2)Large scale implementation of RES based ADUs require favourable legislative and institut ional framework conditions. The action will examine the relevant legislation in EU, AS and MPC, and elaborate a policy initiative for boosting RES based ADUs. Concrete suggestions for how to improve existing EU legislation, such as the EU Water Framework D irective, will be formulated. ADU-RES will make extensive use of the knowledge from previous and on-going R&D actions and bases its dissemination and exploitation plan on the existing networks and communication platforms. The ADU-RES consortium unites the main research players from EU and selected partners from seven MPC. This will mobilise the critical mass necessary to finally bridge the gap between the successful R&D work of the last decade and concrete installations for RES based desalination pl ants in arid Mediterrane
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Investigating the evolution of hydrogenosomes using molecular cell biology' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Recent discoveries suggest that all eukaryotes contain an organelle of mitochondrial ancestry (a homologue), suggesting that the organelle is essential for eukaryotic life. To understand why, requires comparative analyses of diverse mitochondrial homologue s to identify common essential functions. My project will study hydrogenosomes, mitochondrial homologues that make hydrogen, found in diverse anaerobic eukaryotes including trichomonads, fungi and ciliates. I will use a flexible and multidisciplinary approach with training in molecular cell biology and sequence analysis, to address two questions. To investigate a common function for hydrogenosomes and mitochondria, I will determine if ciliate hydrogenosomes can make FeS clusters.This is an essential fun ction of yeast mitochondria and is the leading hypothesis for an essential role of all mitochondrial homologues. I will also investigate how mitochondria are converted into hydrogenosomes. Anaerobic ciliates represent a unique but largely unrealised oppo rtunity to tackle this question, because they have converted their mitochondria to hydrogenosomes on at least four separate occasions. To understand the facility by which ciliates achieve this, I will determine the evolutionary origins of ciliate hydrogenase, the canonical enzyme for hydrogenosomes.I will also investigate whether ciliate hydrogenosomes have retained an organelle genome, providing a direct evolutionary link between the two organelles. I will do this work at Newcastle University where there are excellent facilities with Prof. Martin Embley, an expert on hydrogenosomes. My own expertise in mitochondrial genomics and anaerobic ciliates complements that of Prof Embley, and will ensure a productive and timely synergy. My project is innovative and original an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Immune signatures in sentinel lymph nodes to predict distant metastases in malignant melanoma'.

assistant: **Innovation**

Malignant melanoma is a deadly disease with a 3% lifetime incidence. Currently, no clinically approved companion diagnostics exist for immunotherapy in melanoma, and sentinel lymph node (sLN) evaluation remains the cornerstone of clinical decision-making. A sensitive, robust, and clinically applicable method for identifying patients at risk of developing metastatic disease is urgently needed.Studies in murine models have shown that lymph nodes (LNs) play a dual role in tumor immunity, both supporting immune activation essential for immunotherapy and paradoxically promoting metastatic spread by inducing systemic tolerance. We hypothesized that sLNs exhibit both pro- and anti-tumorigenic roles, varying across patients and disease stages. In a study of 69 melanoma patients, we applied spatial transcriptomics and proteomics to analyze sLNs, revealing immunological organization patterns associated with these opposing roles. A machine learning model trained on this data predicted distant metastases with 93% and 79% accuracy in involved and uninvolved LNs, respectively, demonstrating strong potential to improve clinical diagnostics.Building on these findings, we propose developing a multiplexed imaging panel to profile immune organization in both primary tumors and lymph nodes to guide patient diagnosis and stratification. This panel will be designed for compatibility with clinical workflows and tested on an independent validation cohort of 500 melanoma patients. To pave the way for commercialization, we will explore the market and value chain, identify and engage with relevant industry players and set up a commercialization plan with the aim of positioning our innovation as the new standard for diagnosing and managing melanoma patients. Our diagnostic assay will enhance treat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tailoring Metal-Organic Framework Glasses with Higher Fracture Toughness' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Metal-organic frameworks (MOFs) are a class of organic-inorganic hybrid materials with high porosity. Recently, it has been discovered that a subset of MOFs, namely zeolitic imidazolate frameworks (ZIFs), can be melted and quenched into glasses. This makes it possible to prepare bulk, transparent ZIF glasses with modifiable organic and inorganic building units. However, preliminary results have shown that one of the representative ZIF glasses, ZIF-62, exhibits lower fracture toughness than most traditional oxide glasses. This seriously limits the scope of possible ZIF glass applications within, e.g., gas separation and storage.In the proposed project, we will explore the composition-structure-mechanical property relationship of ZIF glasses. The aim is to optimize the glass composition and structure to achieve improved fracture toughness, while not significantly lowering the strength and stiffness. To this end, we will first systematically vary the ZIF glass structure by tuning the composition, thermal history, and pressure history, in addition to subjecting the glasses to irradiation by heavy ions. Then the mechanical properties of the different glasses will be measured. Finally, these experiments will be complemented by atomistic simulations and machine learning predictions to identify optimized glass structures with improved mechanical performance.The project builds on complementary expertise of the fellow applicant (atomistic simulations, machine learning) and supervisor (mechanics, MOF glasses). Together with the research and training environment provided by the host organization (Aalborg University, Denmark), this will ensure the achievement of this timely and innovative project as well as the dissemination and exploitation of the expected results. The research out
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Benchmark exercise on safety evaluation of computer-based systems' (BE-SECBS) under Fifth Framework.

assistant: **Objectives**

The project is concerned with a benchmark exercise devoted to the evaluation and comparison of techniques for the assessment of a safety-related computer-based system embedded in a nuclear installation, with particular attention to the software part. In this project, the industrial partner will supply a reference case study and all the documentation needed to carry out the benchmark exercise, whilst the other partners will mainly contribute in reviewing known assessment techniques and in applying a subset of them to the case study commonly agreed by all the partners in the course of the project. Comparison criteria will be properly chosen and designed in order to carry out the evaluation and comparison of the involved techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Theileria macroschizont infected cells in vaccination and disease' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

* Study the effect of cell line vaccination on the epidemiology of tropical theileriosis.* Investigate the mechanisms underlying clinical reactions to macroschizont-infected cell lines.* Improve vaccine production and diagnostic tests based on macroschizont antigens; develop a test for protective immunity.* Characterise and isolate the antigens on macroschizont infected cells involved in the generation of immunity and pathogenesis.* Evaluate diagnostic reagents developed by CT95009 in epidemiological studies in Tunisia and Turkey.Expected Outcome* Defining whether cell line vaccination has any effect on the epidemiology of theileriosis.* Development of methods for producing cell line vaccines without attenuation which are safe and effective.* Understanding of the mechanisms by which macroschizont-infected cells and macroschizont antigens induce immunity and pathology and cell line vaccines induce protection.* Identification of potential macroschizont antigens for inclusion in subunit vaccines and antigens involved in pathological immune responses which should be excluded.* Validate new diagnostic techniques for theileriosis for both sensitivity and specificity.* Monitor the efficacy of cell line vaccination in Turkey & Tunisia.* Select and validate diagnostic tests and assess their specificity. In particular study cross reactions between T.annulata and T.hirci/lestoquardi.* Study the cytokine production of potential vaccine cell lines and their correlation with pathology.* Study the role of cytokines and antigen EU 106 in the production of attenuated cell line vaccines without prolonged culture.* Isolate and sequence parasite derived peptides expressed by infected cells and identify which are recognised by cytotoxic T cells from immune animals.* Identify the role of MHC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Living Impact on Fetal Evolution: Shelter-Analyze-Validate-Empower Regulations' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In Europe about 75% of all neonatal deaths and 60% of all infant deaths occur in infants born preterm, and worldwide 450 neonatal deaths occur every hour. The number of preterm births is growing despite advances in medicine as more pregnancies are in the later age but also due to increasing environmental treats and lack of suitable treatments. In the LIFESAVER vision, every pregnant woman must have a proper living environment with the minimal risks to the fetus, safeguarded with scientifically justified regulations in use and control of potentially risky chemical and medicinal products, leading to healthier quality lives of the babies, overarching for generations. The LIFESAVER addresses the presently unmet societal and healthcare needs in creating and developing of a validated scientific knowledge base for the development and implementation of regulatory approaches relevant to maternal and fetal health. The objective is in creation of new, digitally cloned in vitro system for emulation of the pre-natal conditions in the vicinity of uterine/placental interface, capable of future high biofidelity prediction of safety and risk of substances towards unborn babies. LIFESAVER concept is based on an original idea of hybridization of several innovative technologies, integrating digital in silico/in vitro (biodigital twin) systems, enabling effective screening of chemicals and pharmaceuticals which might affect pregnant women health, reducing animal, preclinical and clinical testing, which is not presently possible with any other existing approaches to the same level of confidence.The outcomes are in design, manufacturing and deployment of a platform having key components of in vitro placental tissue for sufficient emulation of typical prenatal conditions. This aims to provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Energy Efficient Ship - application of life cycle analysis' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The industrial objective of this proposal is to participate in the systems identification, systems modelling, systems optimisation and validation activities for the energy-environment systems in transport, but in particular the ships for inland waterways and shortsea traffic, as this under-utilised transport system is prioritised by the European Commission for absorbing some of the growth in transport. The state of the art considers only energy consumption and thus the potential for energy savings in the ship's operational lifetime. Little attention has been focused on a suitable model framework to aid in the construction of the vessels as this is the most important stage in the development of a vessel, where the designer/naval architect fixes the vessels energy life cycle. Utilising Life Cycle Analysis methodology the energy content in (a) materials and components (b) assembly in the shipyard (c) operational life of the vessel and (d) scrapping will be analysed. Life Cycle Analysis has been applied mainly in large corporations and most often for large projects. LCA has also been applied in JOULE projects for wind power. LCA will give the participating SMEs additional expert tools by which the energy efficiency can be improved. Demonstration in model will be done in large scale traffic model. As planned vessels will be used for the analysis, good opportunity exists for validation.