RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Minimal Surfaces in 3-manifolds' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Dr. Coskunuzer will undertake research in Differential Geometry and Geometric Topology. He will investigate the problems in minimal surface theory in hyperbolic space by using topological techniques. There are five main problems in the project. PROBLEM 1: (Universal Cover Conjecture) The first one is a famous classical 3-manifold topology problem, namely The Universal Cover Conjecture. The Conjecture asserts that the universal cover of any irreducible 3-manifold with infinite fundamental group is a 3-ball. This problem is one of the most famous problems in geometric topology. PROBLEM 2: (Intersections of Least Area Planes in Hyperbolic 3-space) The second main problem is about Least Area Planes in Hyperbolic 3-space. In recent years, Dr. Coskunuzer showed very strong generic uniqueness results on the subject. Now, he is studying the intersections of different least area planes with non-transverse asymptotic boundary. He is aiming to prove that these planes are also disjoint. Such a result will have a very wide range of applications in geometric topology. PROBLEM 3: (Properly Embedded Least Area Planes in Hyperbolic 3-space) Dr. Coskunuzer is aiming to prove another ambitious conjecture about the least area planes in hyperbolic 3-space in this project. The conjecture is that any least area plane in hyperbolic 3-space whose asymptotic boundary is a simple closed curve is properly embedded. He already got very strong partial results about the conjecture. PROBLEM 4: (Hyperbolic 3-manifolds with Minimal Foliation) The next problem in the project is the existence of a hyperbolic 3-manifold with foliation by minimal surfaces. This is also a famous question in geometric topology. PROBLEM 5: (Embedded Plateau Problem) The aim is to prove the following conjecture: For any nullhom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ex vivo gene therapy for recessive dystrophic epidermlysis bullosa: pre-clinical and clinical studies' (THERAPEUSKIN).

assistant: **Concept**

We aim to develop ex vivo gene therapy of recessive dystrophic epidermolysis bullosa RDEB. It is caused by loss of function mutations in the collagen VII gene (COL7A1) encoding anchoring fibrils. Patients suffer from skin blistering since birth, and from severe local and systemic complications resulting in poor prognosis. We lack a specific treatment for RDEB, but ex vivo gene transfer to epidermal stem cells shows therapeutic potential. in vitro correction of primary RDEB keratinocytes and fibroblasts by retroviral and lentiviral COL7A1 cDNA vectors was reported. Reports of leukemia caused by retroviral insertional mutagenesis in gene therapy of X-SCID steered us toward safer SIN vectors. In Step I of this project, we will design safe SIN retroviral and lentiviral COL7A1 vectors. Different promoters and viral envelope proteins will be tested for efficient gene delivery and expression in cultured primary keratinocytes and fibroblasts. We will study the proliferative capacity of transduced cells and assess long-term expression of recombinant collagen VII. We will analyse synthesis, folding and secretion of recombinant collagen VII, and its ability to form anchoring fibres in a skin equivalent model and in skin grafts on mice. Vectors will be structed and produced form to GLP standards. In Step II, cell clones producing the highest titres of the selected SIN retroviral or lentiviral vector (mini-cell bank) will be expanded, evaluated, and a unique GMP master cell bank will be established. This MCB will be tested for safety, to be used in the production of clinical grade viral particles. Step III will be a pilot clinical trial (Phase I/II) of genetically corrected autologous skin grafts in selected patients. This project, which combines the complementary expertise of sever
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A Chemical Approach to Understanding Cell Division' (CytoChem), addressing dissemination and exploitation.

assistant: **Impact**

Many mechanisms underlying cytokinesis, the final step in cell division, remain poorly understood. The goal of my laboratory is to use chemical biology approaches to address some of the unanswered mechanistic questions by studying cytokinesis at the process, pathway and protein levels. I aim to discover small molecules that specifically target cytokinesis by different mechanisms because they are important tools to study the biology of cell division and could catalyze the discovery of therapeutics.I am proposing here to use small molecules we discovered to study how the Rho pathway regulates cytokinesis. We will synthesize focused libraries around selected compounds to optimize their properties and to identify sites for affinity tags. I am proposing to identify our small molecules’ cellular targets using a combination of approaches, including a new strategy I designed that takes advantage of the fact that they target a discrete signalling pathway.Rho signalling is involved in every step of cytokinesis, but there are many outstanding questions about how this occurs and which proteins are involved. We have completed a genome-wide RNAi screen that has revealed the identity of new proteins connected to Rho signalling. We will combine functional investigations into how these proteins participate in cytokinesis with our newly discovered small molecules. With this array of tools in hand, we expect to use imaging and other cell-based assays to gain of comprehensive understanding of the role of Rho signalling during cytokinesis and other Rho-dependent processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Novel coatings to prevent biofilm formation on urinary catheters based on nanoantibiotics and quorum quenching compounds' in the context of a Seventh Framework call.

assistant: **Objectives**

NanoQuench project is about the development of alternative methods to coat indewelling medical devices to control microbial biofilms with relevance to clinical drug resistance. Biofilms are bacterial communities embedded in a self-produced polymeric matrix that commonly grow on indwelling medical devices, such as catheters. This mode of growing is believed to be regulated by a quorum-sensing (QS) system, a unique mechanism of communication that bacterial cells use through the secretion and uptake of small hormone-like molecules, called autoinducers. Due to their innate resistance to the immune system and low susceptibility to antibiotics, the microbial biofilms are difficult to treat and are a major factor in the morbidity and mortality of most infectious diseases. Methods by which the initial stages of bacterial attachment and biofilm formation can be restricted or prevented are therefore needed. Technologies that avoid catheter biofilm formation are based mainly on the application of conventional antimicrobial agents. However, the high resistance of bacteria within the biofilm makes any single therapeutic intervention unlikely to have sufficient effect.This project focuses on the development of an integrated technological platform comprising quorum quenching enzymes and novel antibacterial agents (nanoantibiotics), able to counteract biofilm formation and at the same time avoid development of bacterial resistance to the therapy. These functional compounds will be coated onto catheters via layer-by-layer technique or a novel ultrasonic process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Scaling limits of particle systems and microstructural disorder' (PASTIS) targeting Horizon Europe.

assistant: **Abstract**

The present proposal focuses on the role of microstructural disorder in the dynamics of many-particle systems. Due to the complexity of such systems, any practical description relies on simplified effective theories. In the tradition of Hilbert’s sixth problem, I aim at the rigorous large-scale derivation of effective theories from fundamental microscopic descriptions. In those derivations, the role of microstructural disorder has often been overlooked for simplicity. However, disorder is key to many systems and can lead to new behaviors. Understanding its effects in scaling limits of particle systems is, therefore, of fundamental interest.I have selected five model problems illustrating important aspects of the topic. The simplest regime is that of homogenization, where the effect of the disordered background averages out on large scales. For systems like particle suspensions in fluids, microstructural disorder is itself induced by particle positions; as these evolve over time, adapting to external forces, it can lead to nonlinear effects. Another aspect is the emergence of irreversibility: the transport of mechanical particles in a disordered background typically becomes diffusive on large scales, which gives for instance a microscopic explanation for electrical resistance in metals. I also consider the more intricate problem of self-diffusion, where irreversibility rather results from interactions with the ensemble of other particles themselves. A last important aspect concerns the emergence of glassiness, which results from the competition between interactions and disordered background.Mathematically, this proposal is at the crossroads between the analysis of partial differential equations and probability theory and it builds on tremendous recent progress in two of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Light induced spatially EXact and genetically encoded labeling of immune cells for monitoring of lOng Distance and Ultra-compartment Shuttling during autoimmunity and chronic inflammation' in the context of a Horizon 2020 call.

assistant: **Objectives**

The incidence of autoimmune diseases including multiple sclerosis is dramatically increasing. While there is a genetically defined “bedrock” susceptibility to develop T cell mediated autoimmunity, environmental cues likely determine the threshold for disease development. Yet, little is known on how environmental cues sensed at body/environment interfaces are translated into immunopathology in distant organs like the central nervous system (CNS).Here, we raise the hypothesis that immune cells must be activated at epithelial surfaces and then physically migrate to distant organs in order to induce autoimmunity. Furthermore, we propose that the “state of activation” of (either lymphoid or myeloid) immune cells can be interrogated by IL-6 production since IL-6 deficiency confers resistance to virtually any organ specific autoimmune disease and we have contributed fundamentally in defining the role of IL-6 for the generation of Th17 cells that are highly associated with autoimmune tissue inflammation.In EXODUS, we will develop ground-breaking next generation reporter tools in order to test these hypotheses. A split Cre recombinase protein, which dimerizes and is activated by blue light, will be used to genetically label cells (and their progeny) in a topologically defined manner (“compartment reporter”). Furthermore, we have developed a novel type of Cre-inducible in vivo IL-6 reporter (“activation reporter”). The combination of these tools will enable us to trace the anatomical compartment of activation of immune cells without limitations in lag time.Thus, site specific photogenetic co-induction of a fluorescence and IL-6 reporter will be used to probe peripheral sites for their potency to licence immune cells to travel to the CNS (Forward). Vice versa, labeling of cells in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Angular studies of photoelectrons in innovative research environments'.

assistant: **Concept**

In the ASPIRE project, whose academic and industrial beneficiaries are world leading in their complementary fields of expertise, the overarching research goal is the measurement of photoelectron angular distributions (PADs) in the “molecular frame” (MF) of systems of biological relevance. These MF-PADs can be interpreted as electron diffraction patterns, achieved by “illuminating the molecule from within”, and enable the shapes and motions of individual molecules to be interrogated. Such knowledge is needed for the development of new medicines (the shapes of drug molecules dictate their function) and new materials (efficient solar cells can be constructed if energy dissipation processes in molecules are understood). Progress in this area is highly technologically driven, requiring high repetition rate, short wavelength light sources and fast detectors. The input of private sector beneficiaries is therefore critical to the scientific objectives, as well as to the enhanced training environment. Work packages on advanced light source and detector developments will feed into the overall goal through secondments, regular virtual meetings and face-to-face network meetings. The symbiosis of the developments that will take place in ASPIRE will create a research and training environment that is world-leading and optimally tailored to capitalise, for example, on the investment that has been made in the European XFEL facility. The ESRs will be trained in world-leading laboratories and will benefit from the exchange of best practice among beneficiaries and partners, and from unique training events. ASPIRE will therefore ensure that European research remains competitive in the global market, and that the trained researchers will be uniquely well-placed to contribute to the developme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Smart City Innovations and Experiments using New Climate and Energy Simulations' (SCIENCES), addressing dissemination and exploitation.

assistant: **Impact**

As most of the world’s population lives in urban areas, cities play a key role in the use of energy resources and public well-being. The quality of life in cities, as well as the consumption of energy, is highly compromised by the heat they release and the Green House Gases (GHGs) they emit. For this reason, Horizon Europe and other international organizations are committed to supporting research and innovation for the development of climate-neutral and smart cities.Solutions to improve outdoor thermal comfort and reduce GHGs in cities could be more comprehensively studied if physically-based models simulating interactions between buildings and the outdoor environment were integrated into Smart City Digital Twins (SCDTs). The integration of physically-based models into SCDTs is still encountering difficulties, however, and in my research, I propose to overcome these by: 1) automatically configuring a physically-based model from a 3D city model and an Internet of Things (IoT) platform; 2) using statistical models in concurrence with the physically-based model; and 3) simulating temperature, air flow, humidity, and GHGs in the outdoor air, using the physically-based model.While conducting my research at Carnegie Mellon University and Technical University of Delft, I will diversify my skills and competencies through training activities and through the transfer of knowledge from my supervisors. Together, these will enable me to become a world leader in applying urban microclimate modelling to SCDTs. I will also gain experience in team management and teaching to achieve my career goals in academia. Finally, the collaboration with host organizations and one company in Europe will allow me to extend my professional network in the United States, Europe, and industry.


**Keywor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A Centre of Excellence in Computational Biomedicine'.

assistant: **Innovation**

CompBioMed2 is a proposal for the second phase of the Computational Biomedicine Centre of Excellence (CoE), CompBioMed, an outward facing CoE comprising members from academia, industry and the healthcare sector. CompBioMed has established itself as a hub for practitioners in the field, successfully nucleating a substantial body of research, education, training, innovation and outreach within the nascent field of Computational Biomedicine. Computational Biomedicine is an emergent technology that will enable clinicians to develop and refine personalised medicine strategies ahead of their clinical delivery to the patient. Medical regulatory authorities are currently embracing the prospect of using in silico methods in the area of clinical trials and we intend to be in the vanguard of this activity, laying the groundwork for the application of HPC-based Computational Biomedicine approaches to a greater number of therapeutic areas. The HPC requirements of our users are as diverse as the communities we represent. We support both monolithic codes, potentially scaling to the exascale, and complex workflows requiring support for advanced execution patterns. Understanding the complex outputs of such simulations requires both rigorous uncertainty quantification and the embrace of the convergence of HPC and high performance data analytics (HPDA). CompBioMed2 seeks to combine these approaches with the large, heterogeneous datasets from medical records and from the experimental laboratory to underpin clinical decision support systems. CompBioMed2 will continue to support, nurture and grow our community of practitioners, delivering incubator activities to prepare our most mature applications for wider usage, providing avenues that will sustain CompBioMed2 well-beyond the proposed fund
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular Editing by Nitrogen Insertion' (NINSERT).

assistant: **Innovation**

NINSERT constitutes a program to embark on selective and mild nitrogen insertions, both within and beyond carbonyl chemistry. Reagent development, catalyst design, and synergistic effects will be evaluated to provide a platform for late-stage skeletal editing, an area that has been recently brought to the forefront of organic chemistry. With a primary emphasis on heterocyclic motifs, commonly encountered in natural products and drug candidates, NINSERT offers a powerful tool to streamline future syntheses of nitrogen containing compounds. Notably, approximately 59% of all small-molecule drugs feature nitrogen heterocycles, underscoring the profound impact this program will have on pharmaceutical research. Adjusting physicochemical properties by late-stage nitrogen insertion will enable medicinal chemists to tailor the overall compound profile on its way to candidate-nomination and ultimately clinical studies. Furthermore, asymmetric methods, as elucidated in this proposal, will give rise to molecular complexity within the 3D chemical space. Guided by the principles of strain-release and molecular recognition, we will utilize our expertise on asymmetric ring expansion and atom insertion reactions to deliver highly selective methods applicable to both academic and industrial research. Despite the pioneering work of Beckmann and Schmidt over a century ago, nitrogen insertions have remained significantly constrained over the years, largely due to their substrate limitations, harsh reaction conditions, and unselective outcomes. The progression to selective and widely applicable nitrogen insertions has been long overdue and marks a major driving force behind the development of NINSERT.


**Keywords:** asymmetric catalysis, stereochemistry, molecular editing, E, Z-isomerizatio