RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Single-Molecule Acousto-Photonic Nanofluidics' to be submitted under Horizon Europe.

assistant: **Abstract**

Reading biomolecular signatures and understanding their role in health and disease is one of the greatest scientific challenges in genome and proteome biology. Yet, complete protein analysis at the single-molecule level remains an unmet milestone. This pursuit is fundamentally hindered by the huge dynamic range of protein expression in cells and the insufficient spatio-temporal resolution of current analysis methods. Next-generation single-molecule techniques that can precisely manipulate and sequence proteins in space and time are urgently needed to reach this goal. Among these, nanopore platforms are at the forefront, leading in terms of read length, throughput and sensitivity. However, the major challenges associated with translocation speed control and the precise-readout in solid-state nanopore devices, remain prohibitive. In SIMPHONICS, I will resolve these issues by developing the first integrated platform that combines nanopore transport measurements, spatially modulated acoustic wavefields and single-molecule fluorescence time traces to confine, scan and optically fingerprint proteins in a non-invasive and massively parallel manner. The feasibility of this method will be established by attaining three main objectives: 1) Confining and controllably manipulating individual molecules using acoustic nanotweezers; 2) On-demand engineering of 2D material optical emitters as ultrabright fluorescent probes for energy transfer based detection, and 3) Identifying proteins/peptides from their optical signatures in multi-color Frster resonance energy transfer (FRET) during acoustophoresis. With this powerful and unique platform, I will harness the vast potential of acousto-photonic interactions in monolithic nanopore devices. Successful achievement of the project objective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Gene network-based maturation of embryonic stem cell-derived hepatocytes in a microfabricated array' (MICROLIVERMATURATION).

assistant: **Concept**

Embryonic stem cells (ESC) have a limitless capacity for self-renewal a remarkable ability to differentiate, promising a limitless source of cells for cell therapies and tissue engineering. Organ scarcity and lack of proliferative ability makes ESC-derived hepatocytes one of the few potential sources of cells for clinical applications and pharmaceutical drug discovery. However, current techniques for hepatocyte differentiation result in mixed cell populations, minimal metabolic function, and long-term de-differentiation. These differences between mature and differentiated hepatocytes are due to insufficient development of the hepatic transcriptional network during differentiation. Preliminary evidence suggests that modifying the nutritional state of ESC-derived hepatocytes by lowering glucose and increasing fatty acids, mimicking suckling, results in a more mature hepatic phenotype, possibly through the induction of the fatty acid-responsive nuclear receptors, PPARa and HNF4a. This result is interesting as the role of nutrients in differentiation has yet to be elucidated in spite of well known nutritional changes during the pre- and post-natal periods. The hepatic nuclear receptor network is especially important in this context as these ligand-activated transcription factors respond to glucose, sterols, fatty and bile acids offering an epigenetic point of regulation in the development of liver metabolism. The technology which allows us to elucidate and control transcriptional events during differentiation is a microdevice termed the Living Cell Array (LCA). The LCA is a microfabricated device containing multiple GFP reporter cells under microfluidic control allowing high-throughput screening of changes in transcriptional activity during ESC differentiation. The ability
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advanced low cost aircraft structures' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The objective is to reduce the operating costs of relevant European aerospace products by 15%, through the cost effective application of carbon fibre composites to aircraft primary structure, taking into account systems integration. The project will seek to reduce aircraft operating costs by realizing the weight saving potential of composite materials, by reducing the manufacturing costs of composite components, and by reducing maintenance costs. This project will include new design concepts and methods that exploit the full potential of these materials, as well as novel manufacturing and assembly processes. The project will integrate and validate mature and new composite technologies through the design, manufacture and test of appropriate wing and fuselage assemblies that represent both airliner and business jet products.The project will be organized into four technical platforms: The Airliner Wing platform covers inner wing and centre box of a large civil airliner, focusing on the centre box to lateral wing root joint, the landing gear and pylon integration and the highly loaded, complex curvature lower cover. The Airliner Fuselage platform addresses key fuselage challenges and complex design features, including large cut-outs and large damages in curved panels, keel beam and landing gear load introduction, tyre impact damage, post-buckling and elementary crash analysis. The Business Jet Wing platform focuses on reducing cost by combining parts into an integrated wing structure, includes architecture studies to identify the best wing joint configuration. The Business Jet Fuselage platform studies double curved rear fuselage with sandwich shell concept and VTP/HTP and engine integration. A Project Management and Training platform will integrate the technical activities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Robust Silicon-Carbide Technology for Aerospace DC-DC Conversion'.

assistant: **Innovation**

The main aim of this project is to develop a silicon-carbide power module for application within a +/-270Vdc DC/DC conversion network on-board aircraft. This project will investigate the exact requirements and fix the specifications; it will generate the knowledge and understanding required to design and manufacture efficient and reliable power modules; it will deliver fully qualified modules compliant with the aircraft operational environment. Moreover, the project will assess the potential and the risks associated with silicon-carbide technology for the specific case of avionic applications and will provide a thorough and in-depth analysis of future development needs in order to ensure that the stringent requirements of high reliability applications can be met in a cost effective and competitive way. An important aspect of this project will be the investigation of the capability offered by silicon-carbide for the modularisation of power conversion equipment, a key aspect of exploitation for increased industrial competitiveness.The work involved covers design, manufacturing and qualification. To ensure compliance with the applicable reliability requirements, the design will base on a built-in reliability approach during all stages of the workflow. The outcomes of this project will benefit European competitiveness in the field of power conversion system development for avionic applications and will have significant spin offs to other application domains.It is a 24 month project involving two partners, 3 investigators, 4 researchers and 2 technicians. The total value is €479,309 and the requested total contribution is €303,426.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The implementation of EU environmental policies: efficiency issues.' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Implementation issues are currently high on the political agenda in the European Union given the amount of Directives adopted in the early 90's. This research project deals with the description and the economic evaluation of the implementation processes of EU environmental Directives in the Member States. It attempts to answer questions such as: How are the environmental objectives of an environmental Directive modified during the implementation stage ? What are the key differences between implementation processes of EU Directives in France and the UK ? How does implementation affect the economic efficiency and the environmental effectiveness of a particular environmental policy ? The core of the project is twofold. Firstly, it is based on three case studies of the implementation processes of European environmental regulation: the Directive 89/429 regulating emissions of existing domestic waste incinerators, the Directive 88/609 about emissions of SO2 and NOx by Large Combustion Plants and the Council Regulation 1836/93 on EMAS, the European eco-auditing scheme. For each case, the caracterisation and evaluation of their implementation processes will be carried out in 4 EU countries (F, G, NL, UK). Secondly, two aspects of the efficiency are investigated: the environmental effectiveness and the cost efficiency (administrative costs and pollution abatement costs). This proposal involves the following teams: CERNA, the coordinator (F), CSTM, University of Twente (NL), the Free University of Berlin (G), SPRU (UK). Each team will be responsible for the analysis of the implementation processes of the three case studies in its own country. Next to results related to implementation performances, the expected policy oriented findings are the identification of possible implementa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The development of a low cost, easy to use primary healthcare consulation recording, transcription and summarisation multi-modal patient data capture device (MEDISUMM)' (MEDISUMM) under Sixth Framework.

assistant: **Objectives**

The principle objective of this project is to develop a new integrated device for use in the primary healthcare sector in recording, transcribing and intelligently summarising consultations between the healthcare practitioner and the service user, to addre ss the fact that each year, 168,000 EU citizens suffer injury or death as a consequence of incorrect or incomplete medical records. Our proposed programme of work encompasses the following major components: WPl: The creation of new Knowledge in the field s of: spectral analysis of human voice, Microphone design and placement for n-person dialogue capture, communication and vocabulary paradigms within primary health care. WP2: Development of the Speaker Differentiation Module, capable of digitally recordin g the consultation and differentiating between the speakers WP3: Development of the Transcription Module, capable of processing the previously recorded digital audio stream and persistently storing the transcript. WP4: Development of the Summarisation En gine, capable of generating a user-configurable contextual summary of the transcript WP5: Integration and testing of the developed technological innovations into a prototype MEDISUMM device WP6: Carry out innovation related activities such as protection of IPR, absorption of results by participants, dissemination activities, socio-economic studies and promotion of exploitation WP7: Manage the consortium by the active management of innovation related activities, technical activities, legal aspects and oth er issues
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Social capital and enforcement of informal contracts in developing economies'.

assistant: **Concept**

In the absence of formal contracts and sanctioning agencies, many economic exchanges are based on informal arrangements that cannot be enforced through courts or monitored by external parties. In this project, we study the role of social capital in generating social sanctions that agents can use to enforce informal arrangements. Typically, in the literature, social sanctions are posited parametrically, and are supposed to be used unilaterally whenever there is a breach in the  contract . They are thus conceived essentially as an instrument to sustain existing agreements. This argument however relies on unduly restrictive assumptions on the nature and the use of social sanctions: they are costless and they can be used only against  defecting members.  We intend to go beyond the literature by properly modelling what constitutes a social sanction, so as to provide stronger micro-foundations to this concept. We therefore intend to first investigate the mechanisms through which social capital, in the sense of  dense  interdependence between agents,  generates  social sanctions. In a second step, we will explore the impact of social sanctions in sustaining existing agreements, allowing sanctions to be used to force agents to renege on their obligations if such defection is beneficial to their particular group. To give an example, in the context of micro-credit, group members can use social sanctions to enforce repayment of the loan to the bank but, with appropriate norms and beliefs, they can also use the same sanctions to enforce collective default against the lending agency.   At the theoretical level, we will explore the role of social sanctions in micro-credit groups, in collective action problems and in informal insurance arrangements. We shall also carry out two empiric
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The role of adaptive evolution in the success of transposable elements' to be submitted under Seventh Framework.

assistant: **Abstract**

All eukaryotic genomes contain transposable elements (TEs), sequences that duplicate themselves semi-autonomously. Although TEs can have beneficial effects, the vast majority of TE insertions are thought to be either neutral or deleterious. TEs can be harmful because they disrupt important sequences, such as regulatory elements and protein-coding sequences, attract epigenetic markers that can alter expression, and lead to duplication, deletion and rearrangement of DNA through ectopic recombination. Hosts therefore have mechanisms to repress the transposition of TEs, repression that TEs are under selection to avoid. To accomplish this, it is expected that TEs should be undergoing adaptive evolution. In this project we propose to test (i) whether TEs are undergoing adaptive evolution at the primary sequence level, (ii) whether TEs assimilate host gene fragments as a means to escape host silencing, and (iii) whether either strategy leads to an increase in TE success. We will investigate these questions in plants using examples of the two broad classes of TEs: the Sireviruses (class I LTR retrotransposon), and Mutator (class II DNA transposon). We will consider the evolution of these two families in maize and Arabidopsis thaliana, species that have very different genome sizes and numbers of TEs. To the best of our knowledge, the project represents the first attempt to elucidate the correlation between TE evolution and TE success, and only the second attempt to analyze patterns of adaptive evolution in either plant or animal TEs. Based in a highly successful research group in a worldwide recognized institute, and among a network of collaborators across Europe and USA, it will allow the applicant to obtain a strong background in population genetics theory, molecular evolution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Wired: The Role of Infrastructure in the Buddhist Revival in Contemporary China and Beoynd' in the context of a Horizon 2020 call.

assistant: **Objectives**

This project examines the critical and unforeseen role that infrastructure has played in the Buddhist revival in China and in China’s global Buddhist projects. Although both state-led developmental projects and religious revivalism in China have been widely discussed, they are usually treated as separate realms of study, as if one represents material development while the other represents immaterial perspectives. The main objective of my study is to show that these two movements are in fact interlinked and that Buddhism works as a form of infrastructure. I use an in-depth ethnographic method to explore the growing infrastructural connections between developmental and religious projects in Chinese domestic and transitional contexts by looking at Buddhist-related construction projects, schools, internet access, facilities, practices, and policies and their impact on the Buddhist revival in and outside China. My study investigates the much neglected relationship that exists between religious movements in society and infrastructural projects by the state. In doing so, it provides not only an alternative perspective from which to understand religious movements in the context of global China, but, more broadly, it offers a critical and theoretical reassessment of the relationships between materiality and immateriality, human and non-human agency, and object and subject. The University of Copenhagen is an ideal place in which to pursue my project. The Department of Cross-Cultural and Regional Studies uniquely combines interdisciplinary inquiry and study across China Studies, Anthropology, and Religious Studies, all of which are crucial to my project. In particular, my project fits well with the research foci of the Department’s Center for Contemporary Buddhist Studies, a world
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Negative capacitor based on a ferroelectric nano-dot' to be submitted under Horizon 2020.

assistant: **Abstract**

One of the most exciting proposed solutions to the approaching limit of down-scaling in microelectronics (so-called “end of Moore’s law”) consists of the use of negative capacitors, [NegCap]s.      When a NegCap is placed between the gate and the channel of a FET (field-effect transistor), the applied voltage on the gate is strongly amplified on the channel. Therefore, it is possible to reduce substantially the applied gate voltage, yet keeping the voltage on the gate sufficiently high for on/off switching of the FET.     To continue the scaling down of basic electronic components such as FET, reduction of the applied voltage is essential in order to avoid overheating due to the too high power dissipation in the ultra high-density circuits. On the other hand, due to fundamental laws of physics, a minimum voltage of 60mV/decade is necessary for operation of the FET with currently available technologies. A way to solve these conflicting needs is to reduce the gate voltage and in parallel use a NegCap that will amplify the voltage on the channel.      But how to get a negative capacitor? In 2008 Salahuddin and Datta proposed to make NegCap using a ferroelectric capacitor. However, so far, experimental attempts failed to show the stable negative capacitance necessary for the voltage amplification on the FET gate. The key problem is that the ferroelectric splits into domains, which cancels the stabilized negative capacitance effect.    In our ERC-AdG project (“MOBILE-W”), we conceived a concept, supported by theory and modelling, that allows the fabrication of negative capacitors in which splitting to domains is prohibited. Here we aim to demonstrate this experimentally providing proof of concept, and find suitable framework and partners to translate our concept into commerc