RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Laser Ignition - A Twinning Collaboration for Frontier Research in Eco-Friendly Fuel-Saving Combustion'.

assistant: **Concept**

The objective of LASIG-Twin is to create a networking collaboration between the Romanian National Institute for Laser, Plasma and Radiation Physics (INFLPR) and its Laboratory of Solid-State Quantum Electronics (ECS) and four other high renowned institutes from Germany, the UK and France, providing a unique opportunity for INFLPR and its partners to significantly increase their science excellence and visibility, technology innovation capacity and industrial exploitation capability in the fields of laser spark plug for fossil fuel efficient combustion fundamentals and applications. The project will focus on the key target actions of composing Teams of Excellence, an ambitious Training and Lecturing Program and the Roadmap for a future collaboration, organizing short term Staff Exchanges (Training) and Expert Visits (Lectures) that will help raise INFLPR’s research profile as well the one of the partnering institutes, organize two public Summers School type activities, internal and external expert driven Technology Workshops and Business-to-Business (B2B) meetings in conjunction with industry and academia clusters, and finally bringing the world-renowned Laser Ignition Conference (LIC) in 2017 to the INFLPR in Romania to increase INFLPR’s, the Romanian and the European visibility in the fields of Laser Ignition. The technological topic addresses the major challenge of mankind to lower the carbon footprint by efficient energy usage, thus LASIG-Twin will also have a significant societal impact. Dissemination will take care of this aspect by bringing the networking ideas to a broad public, from experts, the science community and industry stakeholder organization, to the interested, non-professional crowd, making society more aware of the importance of fuel efficiency and of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Control and measurement of single macromolecules in space and time' (COSMOS) under Horizon 2020.

assistant: **Objectives**

The desire to “freely suspend the constituents of matter” in order to study their behaviour can be traced back over 200 years to Lichtenberg’s diaries. From radio-frequency ion traps to optical tweezing of colloidal particles, existing methods to trap matter in free space or solution rely on the use of external fields that often strongly perturb the integrity of a macromolecule in solution. Recently, I invented the ‘electrostatic fluidic trap’, a “field-free” principle that supports stable, non-destructive confinement of single macromolecules in room temperature fluids, representing a paradigm shift in a nearly century-old field. The spatio-temporal dynamics of a single electrostatically trapped molecule reveals fundamental information on its properties, e.g., size and electrical charge. The charge of a macromolecule is in turn a strong function of its 3D conformation - the molecular basis of biological function. I now aim to develop a new platform to study 3D macromolecular structure and temporal conformation by measuring the electrical charge of a single trapped molecule in real time, using both optical microscopy and electrical detection. Beyond the conformational dynamics of a single molecule, we will also examine interactions between two or more molecules, and the detection of minute structural differences between closely related molecular isoforms. We will further develop a novel approach to electrical transport measurements on single molecules aimed at generating for the first time a catalog of ‘electrical signatures’ for biomolecules in solution. The ability to experimentally link electrical charge and molecular structure will not only open up a new physical dimension in our understanding of macromolecules, but also advance the development of ultrasensitive, hig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of mass-spectrometry based methods for protein micro-analysis.' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The Biomedical Sciences Research Centre Alexander Fleming", situated in Vari,just south of Athens, is offering one post-doctoral position as a Marie Curie Development Host. The Centre is an independent institution housed in an excellent, well-equipped building. An international atmosphere is strongly encouraged and the Centre makes its facilities available for training of both Greek and international graduate students and post-doctoral scientists. We seek to employ a fellow with a strong background in protein biochemistry, with particular emphasis on the development of mass-spectroscopy techniques for the identification and characterization of very small amounts of protein. The fellow will be expected to develop techniques for the separation of proteins with two-dimensional gel electrophoresis, analysis of post-translational modifications, such as phosphorylation, use of nanospray infusion for the analysis of protein digests by mass spectrometry and identification of proteins by aminoacidsequencing and database searching. The projects in which these techniques will be applied include the study of intracellular pathways initiated by growth factor receptors, signal-transduction by receptors of the Epstein-Barr virus and the study of the components of the enhance some that directs transcription of inducible genes. The fellows will benefit from training in other modern biochemical techniques, such as the analysis of macromolecular interactions using biosensors. Our Centre is an equal opportunities employer and women in particular are encouraged to apply. Applications including a CV and the names of two referees should be addressed to: B.S.R.C. "A. Fleming", 14-16 Fleming St., Vari 166 72,Greece. For informal enquiries contact Dr. G. Panayotou, tel: (30-1) 9656311, fax:(30-1
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Composites under Fatigue: Temperature and Humidity Related Environmental Ageing Damage' (CF-THREAD) under Seventh Framework.

assistant: **Objectives**

This projects aims at substantially improving the understanding of the role played by environmental factors on the long term hydric fatigue endurance of fibre reinforced composites. This will be achieved by an extensive experimental campaign and the development of physically robust finite element based modelling techniques. The will allow predicting the onset of fatigue induced damage in laminates subjected to arbitrary temperature and humidity cycles. Such a modelling capability is the key for establishing equivalence factors between the actual conditions in which composite structural elements are required to operate and the characterization environment employed in the laboratory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploiting non-Standard CSP for Leveraging Applications INtelligence' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The goal of ECSPLAIN is to develop methods, techniques and generic software for modelling and solving rich models of complex, industrial constrained optimisation tasks. More specifically, the project focuses on the resolution of difficult problems often over-constrained" involving multiple optimisation criteria and/or a wide variety of preference constraints. Results, in the form of more powerful Constraint Solver Intelligent Tools, and a methodology for mixed-initiative resolution of complex, constrained optimisation tasks, will be widely published, exploited and commercialised by the ECSPLAIN consortium.Objectives:1) To keep in Europe the world leadership in constraint technology. ECSPLAIN will develop methods, techniques and generic software for addressing over-constrained problems and complex industrial problems involving multiple optimisation criteria and/or a wide variety of preference constraints, ECSPLAIN will enable complex industrial problems to be described explicitly, allowing the modelling of high-level requirements, multiple optimisation criteria and preferences to be captured.2) To improve the efficiency and quality in several areas of industrial activity. The developed methods and software will be applicable to a wide variety of optimisation problems with preferences, including construction planning and forestry management, time-tabling, resource allocation and scheduling.3) To promote the project results and to strengthen IT businesses co-operation with Mediterranean and Middle East countries.Work description:ECSPLAIN proposes to start from analysis of two industrial situations that are representative of complex applications requiring preference manipulation, and to analyse and generalise their overall needs, their user interfacing and interaction requi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Men's Health - impact of prostate-related problems on men in work and society' to be submitted under Fifth Framework.

assistant: **Abstract**

The study seeks to establish, by means of a workshop involving institutional partners and other relevant personnel, a European information base and to develop an interactive network in health institutions that would contribute data to the information base and receive comparative material from it. The aim is to provide a source of information of the state of the art internationally in relation to the most advanced treatment of prostate-related problems; enhance the flow of information to those directly and indirectly affected by the problems; make available information concerning initiatives in education, training and communications ; facilitate in-depth and better focused research; seek to identify institutions of quality as exemplars of evidence based practice; and secure the production of patient centred evidence based information systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Migration and Temporary Agency Work in the EU welfare, tourist and agricultural sectors""' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Migrants constitute the most significant pool of workers at the disposal of the EU member states that wish to expand flexible forms of labour in order to meet the demands of their increasingly ageing and diverse population. They usually fit best the profile of the poor and vulnerable segments of society that would readily take the low status, low pay jobs, yet their freedom of movement towards (and within) the EU labour markets is restricted by inflexible migration policy regimes leaving the space open to a wide array of social networks to construct pathways of entry.Interdisciplinary research touching on the issue of the migrants’ integration in host societies has indicated so far that the ways migrants enter the host country are somehow related with the work opportunities and conditions they experience. This project aims to systematically investigate the factors determining the forms of temporary agency work in specific economic sectors.The key contribution of the proposed study from a conceptual perspective is that it tackles issues having to do with the socioeconomic context of work and its organisation as well as questions related to the socio-political framing of the (migrant) worker’s mobility. From an empirical and policy-related perspective, the significance of this research project consists in addressing the question of temporary agency work in a comparative setting across labour markets with different settings of work and across two EU countries experiencing different and managing differently migration flows.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A Novel Non-Invasive Prenatal Diagnosis for Genetic Disorders' (NIPD), addressing dissemination and exploitation.

assistant: **Impact**

Non-Invasive Prenatal Diagnosis (NIPD) has been one of the most fascinating research fields during the last decade. The identification of small amounts of fetal DNA in maternal circulation has opened new possibilities for NIPD. Up until today, two methods have achieved accurate and validated NIPD methods for trisomy 21. The first NIPD for trisomy 21 was based on next generation sequencing and the second was developed by our group and is based on a MeDIP real time qPCR. However, nothing has been achieved for the NIPD of other genomic disorders caused by pathogenic copy number changes or mutations. The primary goal of this proposal is to develop, validate and provide to clinical practice a novel NIPD method, which will enable fast, sensitive, accurate, robust and cost effective NIPD of the great majority of genetic disorders caused by either pathogenic copy number changes of genomic segments or single and small size mutations. Initially, biomarkers with differential methylation between fetal and maternal DNA located within the entire human exome will be identified using methylation DNA immunoprecipitation and whole-exome massive parallel sequencing. Then a novel MeDIP exome NGS NIPD method for the great majority (~85%) of genetic disorders will be developed and validated. The method will undergo a blind evaluation study using 300 normal and abnormal maternal peripheral blood samples of pregnant women at 10-12 week of gestation. The intellectual property which may arise will be protected by filing internationally PCT patent(s) followed by dissemination of the results of the project. The new method will not only provide a greater number of highly accurate prenatal diagnoses of genetic disorders, but will do so without any risk for the fetus. Thus, the provision of such pren
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Building complex life through self-organization: from organ to organism'.

assistant: **Concept**

A major challenge in regenerative medicine is to create phenotypic functioning tissues by controlling cell behaviour. We particularly lack the ability to form complex tissues composed of multiple cell types and with three-dimensional architecture, which are defining features of most tissues. We know that cells are conferred with the ability to choreograph their own development through self-organization. I hypothesize that if we actively promote this intrinsic capacity with new cell culture platforms, we can orchestrate self-organization to make complex tissues, organs, and even organisms with a high degree of reproducibility and in large numbers. This proposal begins with the design and development of new cell culture platforms which will be used to test my hypothesis. Building upon our proprietary microfabrication and -fluidic technology, we will create advanced platforms that will control how cells aggregate and enable the application of biomolecules with spatial and temporal resolution to orchestrate self-organization. This technology will be transferred into three projects of increasing complexity and ambition: making in vitro models of pancreatic islets, the pituitary gland, and a mouse blastocyst. For each, we need to find the right conditions to enrich for desired phenotypes and functions, which means that we need quantitative read-outs. We will use state-of-the-art biological methods, including RNA-sequencing, to give us a holistic view of transcript expression and pathway activation, and in situ sequencing to allow us to pinpoint the expression of important phenotypic markers at a single cell level. The anticipated outcomes of this proposal are three-fold: first, we will develop a new generation of cell culture platforms with integrated microfluidics; second, w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Designed Plant Breeding by Control of Meiotic Recombination' (COMREC), addressing dissemination and exploitation.

assistant: **Impact**

Agriculture depends on breeding. Breeders try to combining desirable and eliminating unfavourable traits of crop plants. Changes in genetic linkage are based on meiotic recombination. Although techniques for the transfer of single traits have been developed, resulting in genetically modified organisms (GMOs), hardly any effort has been undertaken to control the exchange between parental genomes as such. By applying new molecular tools to control recombination the current project aims to establish a new kind of ¿designed¿ plant breeding. Thus, not only transfer or elimination of specific traits should become possible in a programmable way, but also the access to the complete gene pool of natural species and its widening by crossing in closely related species should become feasible. Suppression of recombination should result in an apomixis-like propagation of elite cultivars. Mainly two different levels of control will be addressed in the project: the induction of recombination at predefined specific sites in the genome and the regulation of the level of genome-wide exchange. For the former approach we will apply specifically tailored sequence-specific zinc-finger and meganucleases. Global changes should be achieved by modulating the expression of factors involved in the resolution of recombination intermediates. As the strategy relies on the exploitation of the natural mechanism of recombination, biotechnologically improved plants without transgenes will be obtained after outcrossing. Thus, public concerns raised by GMOs brought out in the field should be avoided. As recent technical improvements make the elucidation of genomic sequences possible at moderate cost and time requirements, the setup of ¿designed¿ breeding should become especially useful in the near future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for '“Discover Europe”- Romanian Mobility Centre initiative to strengthen ERA-MORE' (2007-2013).

assistant: **Innovation**

The strategic objective of DISCOVER Europe project is to strenghten the ERA MORE network by stimulating the cooperation between the European Mobility Centres. In order to attempt this ambitious goal two specific objectives have been consider: (a) To increase the expertise of the New Member state Mobility Centre (Romanian and Bulgarian) using the experience of other European Mobility Centres in order to reduce the disparities between the network members; (b) To set up a pilot action aimed to support the networking with other European Centres in order to increase the cooperation within the ERA-MORE network. Through this ambitious goal the Discover Europe project will support the removing obstacles to mobility and enhancing the career perspectives of researchers in Europe both coming or going to the two New Member Stats (Romania and Bulgaria). Also, the ambition of Discover Europe project is to highly increase the level of ERA-MORE services across Europe, especially in the view of 2008 when a substantial new scheme for international collaboration on human resources partnership scheme focusing on staff exchange between several European research organisations and organisations from countries covered by the European Neighbourhood Policy will be officially lanced.