RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A Framework for electrical power sysTems vulnerability identification,dEfense and Restoration' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

AFTER project addresses the challenges posed by the need for vulnerability evaluation and contin-gency planning of the energy grids and energy plants considering also the relevant ICT systems used in protection and control.Project emphasis is on cascading events that can cause catastrophic outages of the electric power systems.The main addressed problems are related to high impact wide spread multiple contingencies, the most significant wide area criticality. This kind of contingencies and the following cascading effects can be caused by deliberate acts of terrorism, sabotage, criminal activity, malicious behaviour etc or they can simply be caused by a combination of accidents, natural disasters, negli-gence.Both risk analysis and risk mitigation will be pursued.In particular, two major objectives are addressed.The first is to develop a methodology and tool for the integrated, global vulnerability analysis and risk assessment of the interconnected Electrical Power Systems considering their interdependencies.This objective meets the TSO (Transmission System Operator) need to overcome current approaches based on separate evaluations of either power system or ICT system. Further, the adoption of risk concepts allows a more in-depth, quantitative evaluation of the security of the electrical power system.The second objective is to develop algorithms and tools supporting contingency planning in a two-fold approach:• preventing or limiting system disruption, by means of physical security techniques and defence plans; and• re-establishing the system after a major disruption, by means of restoration plans.To this aim, AFTER propose the use of the global risk assessment methodologies as a support to defence plan design.  A language to model defence plans functionalities and ICT a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Molecular Dynamics Simulation Tools'.

assistant: **Objectives**

Trinity College Dublin has world-class research scientists working the in fields of experimental and theoretical nano-sciences (nano-phyiscs) and experimental life sciences (including bio molecular modelling, protein folding, compound screening and drug discovery/delivery systems). The University is recognised for its strong research capabilities in the areas of high performance computing and algorithm design in the physical and biological sciences. Terascale computating with storage facilities, and immersive visualisation facilities will be an integral part of the consolidation of the computational scientists in the new Information Technology and Advanced Computing programme in Trinity.Trinity has identified a gap in the multidisciplinary competencies of the University between these two exciting areas of research. The objective of this proposal is to strengthen the bridge between these two competencies and to provide new validated molecular dynamics simulation tools to enhance the research capabilities of the bioscience and nanoscience groups. This objective will be achieved by transferring the experience of experts to assist in identifying the needs of these scientists and working with local researchers to customise existing molecular dynamics packages t o meet their requirements.The work will lead to faster, more efficient MD calculations in the Nano/Life sciences. The close interaction in Trinity between the bio/nanoscientist and computational science groups is somewhat unique in Europe. This program me will offer the external researchers access to real data in order to validate software tools. Visiting researchers will be invited to participate in the postgraduate teaching programme and to get involved in the variety of outreach activities organised by the Universi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Discovering and Analyzing Visual Structures'.

assistant: **Objectives**

The goal of this project is to shift the dominant paradigm of learning-based computer vision: instead of systems attempting to replace human interpretation by providing predictions, we will develop approaches to assist experts in identifying and analyzing patterns. Indeed, while the success of deep learning on visual data is undeniable, applications are often limited to the supervised learning scenario where the algorithm tries to infer a label for a new image based on the annotations made by experts in a reference dataset. In contrast, we will take as input images without any annotation, automatically identify consistent patterns and model their variation and evolution, so that an expert can more easily analyze them.I will introduce and develop the concept of visual structures. Their key features will be their interpretability, in terms of correspondences, deformations, or properties of the observed images, and their ability to incorporate prior knowledge about the data and expert feedback. I propose two complementary approaches to formally define and identify visual structures: one based on analyzing correspondences, the other on learning interpretable image models.We will develop visual structures in two domains in which breakthrough progress will open up new scientific discoveries: historical documents and Earth imagery. For example, from temporal series of multispectral Earth images, we will identify types of moving objects, areas with different types of vegetation or constructions, and model the evolution of their characteristics, which may correspond to changes in their activity or life cycle. Ultimately, experts will still be needed to select relevant visual structures and perform analysis, but DISCOVER will revolutionize their work, trivializing tedious annotat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'SMART community-led transition for Europe's Rural Areas' under Horizon Europe.

assistant: **Concept**

Depopulation, mostly characterized by emigration of young people, is occurring in rural areas all over Europe. This has brought to an ageing phenomenon, as well as the emergence of several structural problems such as fewer job opportunities, degradation of infrastructures and a decreasing offer of services of general interest. However, the revolution in digitalisation with an increase of remote and location-free work opportunities is offering the chance to redirect some rural migration flows back. Interventions are thus needed to take up this opportunity and build on trends such as multi-local living to promote new greener, smaller, sustainable and innovative growth models. It is there where SMART ERA intervenes. The project will foster resilience in rural areas, by upgrading and co-designing, co-developing and co-validating with local communities a set of smart solutions, integrated within Smart Innovation Packages (SIPs) able to tackle pressing socio-economic and environmental challenges and promote a community-led transition pathway that will empower rural people to act for change. SMART ERA’s main ambitions are: a) building the first large-scale European-wide solution for systematic rural data screening and smartness analysis; b) using co-design methods and techniques to involve residents and stakeholders in the design and validation of SIPs, as well as in the collection of old and creation of new data sources; c) proposing a unified Smartness/Digital Maturity assessment method; d) providing unique and timely evidence-based and performance-focused recommendations to upgrade the new local, national and European policy instruments and enhance their efficiency and efficacy in supporting smart villages across the EU; e) fostering cooperation among pilot regions, as well
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'GlucoCEST Imaging of Neoplastic Tumours' (GLINT) targeting Horizon 2020.

assistant: **Abstract**

Cancer is one of the most devastating diseases the world is currently facing, accounting for 7.6 million deaths in 2008 (WHO). Cancer is usually detected through advanced medical imaging. Early detection is very important as it increases the chances of survival and the potential for full recovery. Further, The high level of sophistication in treating cancer has led to a new unsolved problem, the differentiation between treatment effect, regrowth or pseudo-progression of the tumour. Here, we aim to develop and bring to the clinic a potentially disruptive new technology to characterize and image glucose delivery, uptake and metabolism in cancer.Recently we managed to demonstrate the sensitivity of a technique, named glucose-based Chemical Exchange Saturation Transfer (glucoCEST), to detect native (α-D-glucose) glucose uptake in tumours. In addition, recent developments have shown glucose analogues, such as 3-oxy-methyl-D-glucose (3OMG) can be used as potential non-metabolisable tracers using the same technique.In this proposal, we aim to bring the combination of native D-glucose and 3-oxy-methyl-D-glucose as a combined examination to the clinic to assess cancer glucose uptake and metabolism, thereby providing a cheap, widely available, more comprehensive, non-invasive alternative to nuclear medicine techniques currently used for cancer assessment within Europe.


**Keywords:** cancer, biomarker, imaging, metabolism, glucose, GlucoCEST, MRI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Strengthening Environmental Surveillance to Advance Public Health Action'.

assistant: **Innovation**

The ODIN project aims at strengthening capacity for genomics and bioinformatics database management skills for generating, maintaining, and querying large genomic epidemiology data sets in sub-Saharan countries. To reach this goal, ODIN will develop a genomic surveillance system relying on environmental monitoring of major communicable disease agents and antimicrobial resistance in community wastewater and other environmental samples containing human and animal excreta. In a socially and ethically acceptable anonymous manner, environmental surveillance systems follow the trends in prevalence and may detect the outbreaks of communicable diseases in human communities and to convey this information to key stakeholders for the efficient implementation of data-driven public health policies. A strong and innovative aspect of this project is the combination of various semi-automatic bioinformatics tools for the processing and analysis of genomic epidemiology data, disseminated through a visual dashboard, providing means for timely public health interventions. The ODIN project implements the three pillars of the One Health framework: human health, animal health and the environment, which is crucial for communicable disease epidemiology in resource- and infrastructure-poor regions. Together with extensive training activities, ODIN implementation will result in a substantial strengthening in the capacity and infrastructure in sub-Saharan countries for genomic epidemiology. Networking and capacity building are an integrated part of the project activities and will comprise communication activities with stakeholders and training of MSc and PhD students. By its multi-disciplinary team, ODIN will contribute to setting up a sustainable model for how environmental surveillance systems c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Stretchable Electronic Skins'.

assistant: **Objectives**

Future electronic systems will be soft and elastic.  I propose to explore the materials, technology and integration of stretchable electronic systems, which will transform at will, evenly coat a spherical lens, or smoothly interface with a delicate biological organ.  Electronics will be anywhere as well as everywhere.  The proposed programme has the potential to emulate yet another revolution in the microelectronics industry and trigger transformations in the biomedical sector.The ESKIN programme is an ambitious and highly interdisciplinary endeavour requiring expertise at the frontier of engineering, material sciences, biotechnology and neuroscience.  Stretchability in an electronic system is its ability to negotiate mechanical deformations without letting them interfere with its electrical functionality.  This is a novel and challenging demand on electronic device technology, which has, to date, mainly pushed for smaller scale fabrication and increased performance.  Furthermore the natural compliance of biological tissues and cells calls for softer electronic biomedical interfaces.  Overcoming the  hard to soft  mechanical mismatch will, without doubt, open up new horizons in biomedical research and its related industries.The manufacture of stretchable electronic skins will then require working out the underlying science and technology for active device materials on soft, elastic substrates.  This capability will further be implemented to demonstrate various  soft and elastic electronic systems  ranging from stretchable displays to long-term neural implants.  My philosophy is to exploit as much as possible current micro/nanofabrication techniques available for  hard surfaces  but to tailor them to  soft surfaces , optimizing and improving them where needed, in order t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Assessing the effect of early social environment on epigenetic modification' in the context of a Seventh Framework call.

assistant: **Objectives**

Genetic and environmental factors shape resiliency and vulnerability to psychiatric disorders, as in other complex inheritance diseases. Recent studies show that environmental factors can exert their effects through epigenetic modifications, such as DNA methylation, affecting expression level of crucial genes. Pre- and postnatal environment (e.g. maternal diet, stress, early care) in critical periods of development can lead to long-lasting effects in the offspring, possibly to prepare the individual for the anticipated environment. Assessing epigenetic changes leading to psychiatric disorders has been limited to date, because epigenetic modifications are tissue-specific, and only postmortem studies could use brain tissues. However, with genome-wide analyses it became possible to discover similarities of epigenetic changes in different tissues. DNA methylation pattern of certain gene regions could be concordant in the brain and accessible cells (e.g. leukocytes or buccal cells). I have been studying genetic factors in the development of psychiatric disorders, and I plan to include epigenetic markers in my future projects. I could acquire first-hand knowledge of epigenetics by carrying out a research project assessing the impact of prenatal maternal depression and care-giving quality on epigenetic modification. Specific aims of the outgoing phase are to (1) confirm microarray-derived DNA methylation patterns of selected genes in the brain and T lymphocytes, (2) develop a high-throughput method for a panel of informative epigenetic markers in T cells, and (3) assess the usability of saliva and buccal samples. The successful application of non-invasive sample collection would greatly promote epigenetic analyses in large-scale, population-based studies. In the return phase t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Use of indigenous n2-fixing cyanobacteria for sustainable improvment of soil biogeochemical performance and physical fertility in semiarid tropics' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Two major aspects of the interactions between indigenous cyanobacteria inoculantsand degraded soils in Semiarid Tropics will be analysed: l) the influence of N2 fixing activity on soil biogeochemical performance (nutrients status, OM content and turnover etc.) and 2) the role of secreted exopolysaccharides, for improving soil chemical-chemical properties and reducing adverse physical processes such crusting, clay dispersion, erosion etc. The most suitable protocols will be established for enabling small rural communities to grow a selected strains of indigenous active cyanobacteria. In each Daces a selected team of local farmers will be trained and instructed on how to manage and maintain these simple culture systems and on how to spread the cyanobacteria in the field. Models will be developed to predict the short and long-term effects of such practices on overall soil fertility and productivity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Resetting mechanisms of the plant circadian clock' under Sixth Framework.

assistant: **Concept**

Circadian clocks regulate many cellular/physiological processes allowing the organisms to adapt to the predictable daily changes in the environment. At the core of the clock, components of the central oscillator mutually regulate their expression/activity via multiple feedback loops that results in an autonomous, self-sustained ~24h oscillation.As the period of the core oscillation deviates from 24h, the clock must be synchronised to the environmental cycles in order to provide precise temporal information. In nature, this resetting occurs daily in response to periodic environmental cues (e.g. temperature, light). Light is absorbed by specialised photoreceptors and signals are forwarded to the oscillator where they cause an acute change in the level/activity of certain clock components that eventually results in a phase shift of the oscillation. By using luciferase reporters in different fusion constructs, the transcription/translation rates and protein abundance of the clock components will be measured in wild type transgenic plants before and after light pulses given at different times of the day.The results will indicate the clock components that are first affected by the light pulse and therefore could be the primary targets for resetting signals, and the sequence of the molecular events resulting in a phase shift. A novel transient UV-B-specific inducible expression system will be used to replicate the effect of light induction of the clock components and corroborate the previous results. Next, a series of truncated phytochrome B (PHYB) photoreceptor proteins will be used to complement the phyb null mutant to identify the minimal fragment of PHYB that is sufficient to mediate red light specific resetting. This shortest fragment will also be tested for its potential
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Learning and practicing pharmacovigilance in the Mediterranean countries of the EU' under Sixth Framework.

assistant: **Concept**

Pharmacovigilance consists in collecting and analyzing the adverse reactions to medicines following their market authorization it is an essential practice to ensure public health. The recognition and notification of Adverse Drug Reactions is a complex task requiring knowledge and expertise from both health practitioners and patients.The Med ePHV project intends to study and develop a new approach to pharmacovigilance practice in order to improve ADRs recognition and notification. The project does not interfere with the pharmacovigilance activity of the European Agency and the National Authorities as the issue addressed by Med ePHV takes place in the periphery of the health systems at the interface between health practitioners and patients.The research is proposed by a group of SMEs of France Italy and Spain that notice significant market opportunities in the development of on line products and services in support to pharmacovigilance. The new pharmaceutical legislation approved by the European Commission in 2003 aims to an improved pharmacovigilance within the EU and recommends a more efficient ADRs recognition and notification.The Med ePHV project will focus on the medical culture and practice of three Mediterranean countries France Italy and Spain During the last phase of the project the Consortium will search the most suitable network based application grids models to define the most cost effective platform useful to support a heavy multi user e-learning programme.As the main project goal is allowing end users to learn and train on pharmacovigilance innovative e learning and to practice in a user friendly knowledge based environment ADRs recognition and notification a key task of the project will be the testing and validation of the on line modules by target end user