RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Machine learning approaches to epigenomic research' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Epigenomic research has become one the fastest evolving fields in molecular biology. Epigenetic effects control the packaging of DNA in the nucleus thereby deeply influencing gene expression. They also play crucial roles in cell differentiation and aberrant patterns are associated with cancer, mental disorders and autoimmune diseases. However, our understanding of the epigenomic code is still limited. A main obstacle to its decoding is the requirement for immensely data-intense experiments, as epigenomic configurations embrace multiple different marks which form an intricate interplay that varies between cell types. Advances in high-throughput sequencing resulted in a plethora of complex data sets and computational methods are called upon to solve pressing questions for their analysis and modeling. In this project, we will develop machine learning tools to combine epigenomic measurements with computational sequence analysis. This will provide us with a better understanding of the extent to which DNA sequence controls the establishment of epigenomic marks. It will also serve as a credible basis for data integration. We will next combine data from different cell lines and analyze them simultaneously. In particular, we will examine the effect of a certain transfactor, by comparing histone marks in wild type ES cells with mutants that lack the DNA-binding protein Cfp-1, which is known to play a role in the formation of epigenomic marks at active promoters. To shed light on the epigenomic impact on the transcriptome the framework will eventually be complemented by adding expression data. The proposed research will doubly benefit the applicant by introducing her to a new field of application, as well as a wider class of computational techniques. We believe this work to be of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovative technology for milk safety' (SAFEMILK).

assistant: **Innovation**

The proposal is focused on the development of novel complex assay for evaluation of milk safety, which is important for dairy industry to assure required safety and quality of milk and dairy products. The complex biosensing assay will be focused on development of the methods for rapid and sensitive detection of bacterial pathogens and antibiotics that could occur in milk and represent potential hazard for health. Nine experienced academic/research institutions, two SMEs and one governmental business company from 3 EU member states (Slovakia, Hungary, Greece) and from 2 third countries (USA and Canada) will be involved in the research, development and verification of assays for detection of bacterial pathogens and antibiotics in milk. The focus will be on application of surface acoustic, electrochemical and optical methods using nanofabricated surfaces with immobilized DNA aptamers for detection of pathogenic bacteria and antibiotics. The output of the project will be the development of novel analytical assays, staff exchange between academic institutions and SME, training of the students in novel analytical methods, and sensor development in world leading laboratories. The important result of the project is optimized complex assay for efficient assessment of milk safety, which could be commercialised by the project industrial participants. The organization of training schools, workshops and transfer of novel technology will be among priorities of this proposal.


**Keywords:** Biosensors; Milk; DNA aptamers; Bacteria; Antibiotics; Nanotechnology; Molecular engineering; Acoustic; Electrochemistry; Fluorescence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hierarchical Carbon Nanomaterials' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Over the past years, carbon nanomaterial such as graphene and carbon nanotubes (CNTs) have attracted the interest of scientists, because some of their properties are unlike any other engineering material. Individual graphene sheets and CNTs have shown a Youngs Modulus of 1 TPa and a tensile strength of 100 GPa, hereby exceeding steel at only a fraction of its weight. Further, they offer high currents carrying capacities of 10^9 A/cm², and thermal conductivities up to 3500 W/mK, exceeding diamond. Importantly, these off-the-chart properties are only valid for high quality individualized nanotubes or sheets. However, most engineering applications require the assembly of tens to millions of these nanoparticles into one device. Unfortunately, the mechanical and electronic figures of merit of such assembled materials typically drop by at least an order of magnitude in comparison to the constituent nanoparticles.In this ERC project, we aim at the development of new techniques to create structured assemblies of carbon nanoparticles. Herein we emphasize the importance of controlling hierarchical arrangement at different length scales in order to engineer the properties of the final device. The project will follow a methodical approach, bringing together different fields of expertise ranging from macro- and microscale manufacturing, to nanoscale material synthesis and mesoscale chemical surface modification. For instance, we will pursue combined top-down microfabrication and bottom-up self-assembly, accompanied with surface modification through hydrothermal processing.This research will impact scientific understanding of how nanotubes and nanosheets interact, and will create new hierarchical assembly techniques for nanomaterials. Further, this ERC project pursues applications wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A STATIC MIXER REACTOR FOR STARCH GRAFT POLYMERISATION' (STAMISTAP), addressing dissemination and exploitation.

assistant: **Impact**

The objective of StaMiStAP is to develop a novel, continuous process for the starch polymerisation reactions on the basis of static mixing elements.A continuous static-mixer reactor is attractive for commercial starch polymerisations because the static mixer reactor has excellent micromixing and plug-flow behaviour, shows good heat transfer characteristics, has a low pressure drop while processing viscous systems, and is easy to scale up. Therefore, StaMiStAP is an innovative approach to develop novel reactors for starch polymerisation reactions.StaMiStAP aims to develop a continuous, bench-scale static-mixer reactor for grafting of (poly)acrylates onto starch. Starch-g-acrylic copolymers are widely known at laboratory scale and exhibit attractive properties for use as, among others, super-absorbents, oil-drilling muds, and paper strengthening agents. Grafted starch-acrylic copolymers are at least partly biodegradable and non-toxic polymers. The product properties, such as mechanical strength and biodegradability, will depend on the process conditions and the optimum product quality will be evaluated as a function of the relevant operation parameters. Prospective products will be tested in the market and their marketability will be assessed.StaMiStAP contributes to the development of continuous processes for the starch industry in general and commercial production of starch-based polymers in particular. Continuous processes will improve the competitiveness of the European starch industry as a result of increased automatic process control and well-defined product quality. Furthermore, development of at least partly biodegradable starch-acrylic copolymers to replace current polyacrylates is stimulated by European environmental legislation and increasing green consumerism.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Enriching HDR edits for enhancing efficacy and precision of HSPC gene therapy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Hematopoietic stem and progenitor cell (HSPC) gene therapy involving viral vectors has shown remarkable promise in treating severe genetic disorders. The advent of gene editing technologies offers new possibilities for broadening the scope of HSPC gene therapy by enabling precise in situ gene correction or targeted transgene integration through homology-directed repair (HDR). However, HDR efficiency in HSPCs remains limited due to their cell cycle dynamics, suboptimal responses to the repair template, and the dominance of error-prone DNA repair pathways such as non-homologous end joining (NHEJ) and microhomology-mediated end joining (MMEJ), which negatively impact the engraftment of HDR-edited cells in vivo. This proposal aims to overcome these challenges by introducing an innovative ""purifying selection"" strategy. By using CRISPR/Cas9 to target essential genes that are haplo-insufficient in HSPCs, only cells undergoing HDR-mediated insertion of the gene of interest (GOI) will restore the function of the essential gene, while non-HDR edited cells will fail to recover, leading to their elimination. This selective enrichment of HDR-edited cells will dramatically enhance the precision and efficacy of gene editing. ENRICHING-HDR project will focus on identifying critical genes required for HSPC survival and maintenance through genome-wide CRISPR screening, selecting the most promising candidates for purifying selection, and evaluating the system's precision and platformability for clinical application. This project will establish a standardized platform for guide/nuclease reagents and template delivery, enabling reliable genomic integration and rapid adaptation of new therapeutic transgenes, streamlining the development of targeted therapies. The comprehensive training in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Nanoparticle probes for photoacoustic tracking of stem cell'.

assistant: **Innovation**

Better understanding on stem cell tracking is required before regenerative medicines therapies (RMTs) can be used. However, there is not a single molecular imaging technology capable of providing the breadth of information required. For instance, while MRI offers excellent spatial resolution, sensitivity is low, whereas for SPECT/PET, the converse is true.In this context, the combination of nanotechnology and new imaging techniques such as photoacoustic imaging (PAI) emerge as potential disruptive technology. Biocompatible nanoprobes can be rationally designed to label specific cell without interfering with biological parameters such as differentiation or metabolic processes but improving the contrast of the imaging technique. Gold nanorods and more complex structures such as hollow nanoparticle or hybrids show special optical properties that enable their use as contrast agents for PAI achieving then enough sensitivity to monitor single cells. Moreover, these optical properties are easily tunable and can be adjusted to perform a multiple real time labelling thanks to the rapid acquisition and the extremely high resolution of PAI. Thus, the combination of these two technologies together will provide a non-invasive, long term, in vivo cell tracking of stem cell in models of kidney  injury already developed and validated. Thus, the amelioration of fibrosis and the recovery of renal function amongst other will be assessed together with the safety studies that will include biodistribution, tumourigenesis, inflammation, systemic toxicity, etc. All together will contribute to establish efficacy and safety of RMTs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Stochastic Population Biology in a Fluctuating Environment' (STOCHPOP) under Seventh Framework.

assistant: **Objectives**

The aim of this project is to produce a new synthesis integrating ecological and evolutionary processes. This synthetic approach is based on the fundamental premise that the effects of environmental stochasticity are essential for the understanding of biological processes at every time scale because all natural populations are exposed to a fluctuating environment. Following my recent advances in the development of stochastic population models I will in this proposal address three questions. First, I will examine to whether the ecological effects of a fluctuating environment can be predicted from some basic set of characters distributing species along a slow-fast continuum of life history variation. Secondly, I will using my own long-term study systems partition selection on fitness-related traits into different hierarchical components, which all must be estimated for predicting the rate of evolutionary changes in quantitative characters. Thirdly, I will examine to what extent using a comparative approach how the strength of fluctuating selection caused by environmental change is predictable from basic life history characteristics. I expect that any emerging patterns arising from the evaluation of these hypotheses will represent a major break-through in evolutionary biology because it will enable identification of general principles and processes that affect the rate of change of populations both at ecological and evolutionary time scales and hence provide tools for development of quantitative predictions for the expected rate of Darwinian evolution in fluctuating environments. I further anticipate that the knowledge advanced will have significant implications for research in population biology and its future application in applied conservation biology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Zero-touch security and trust for ubiquitous computing and connectivity in 5G networks.' under Horizon 2020.

assistant: **Concept**

Despite the progress of last years, 5G today is not yet at a stage of complete achievement of the promised performances and functions: different application profiles (eMBB, URLLC, mMTC) do not easily coexist in network slices; slicing is casted in various different forms; network analytics are not at end-to-end scope; services do not span multiple operator domains yet. 5GZORRO consortium envisions the evolution of 5G to achieve truly production-level support of diverse Vertical applications, which coexist on a highly pervasive shared network infrastructure, through automated end-to-end network slicing, across multiple operators and infrastructure/resource providers, who can share heterogeneous types of resources (spectrum, virtualized radio access, virtualized edge/core). 5GZORRO uses distributed Artificial Intelligence (AI) to implement cognitive network orchestration and management with minimal manual intervention (Zero-Touch Automation). Distributed Ledger Technologies (DLT) are adopted to implement flexible and efficient distributed security and trust across the various parties involved in a 5G end-to-end service chain. With these, we can implement an evolved 5G Service Layer for Smart Contracts among multiple non-trusted parties, to allow SLA monitoring, spectrum sharing, intelligent and automated data-driven resource discovery and management. Our cross domain security & trust orchestration coupled with service lifecycle automation can enforce security policies in multi-tenant and multi-stakeholder environments. Three use cases validate our research in 5GBarcelona and 5TONIC/Madrid test facilities: Smart Contracts for Ubiquitous Computing/Connectivity, Dynamic Spectrum Allocation, Pervasive virtual CDNs over 3rd-party edge resources. 5GZORRO target stakeholders are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Data Driven Computational Mechanics at EXascale' (DComEX), addressing dissemination and exploitation.

assistant: **Impact**

DCoMEX aims to provide unprecedented advances to the field of  Computational Mechanics by developing novel numerical methods enhanced by Artificial Intelligence, along with a scalable software framework that enables exascale computing. A key innovation of our project is the development of AI-Solve, a novel scalable library of AI-enhanced algorithms for the solution of large scale sparse linear system that are the core of computational mechanics. Our methods fuse physics-constrained machine learning with efficient block-iterative methods and incorporate experimental data at multiple levels of fidelity to quantify model uncertainties. Efficient deployment of these methods in exascale supercomputers will provide scientists and engineers with unprecedented capabilities for predictive simulations of mechanical systems in applications ranging from bioengineering to manufacturing. DCoMEX exploits the computational power of modern exascale architectures, to provide a robust and user friendly framework that can be adopted in many applications.  This framework is comprised of AI-Solve library integrated in two complementary computational mechanics HPC libraries. The first is a general-purpose multiphysics engine and the second a Bayesian uncertainty quantification and optimisation platform. We will demonstrate DCoMEX potential by detailed simulations in two case studies: (i) patient-specific optimization of cancer immunotherapy treatment, and (ii) design of advanced composite materials and structures at multiple scales. We envision that software and methods developed in this project can be further customized and also facilitate developments in critical European industrial sectors like medicine, infrastructure, materials, automotive and aeronautics design.


**Keywords:** Data Dri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Reviewing education and training for governance and active citizenship in europe-a central and eastern european perspective' (RE-ETGACE) targeting Fifth Framework.

assistant: **Abstract**

The current project, builds on the ETGACE philosophy (a Fifth Framework founded Research Project on Governance and Active Citizenship). It will by lead by inactive partner from ETGACE consortium (The Netherlands) and will have as members two other active partners from ETGACE, Belgium and Slovenia. It will have scientific Advisory Board from all six partners of the ETGACE research. It has major implications for two EU associated states: Hungary and Romania. There are three fundamental tasks of the RE-ETGACE:- Developing insights about the learning of governance and active citizenship in Hungary and Romania, with the help of a replication of the ETGACE research; -Studying and developing methodology for the comparative researches in the context of social sciences in general, adult education in special;-Preparation of the new consortium in the context of the Sixth Framework Programme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'fifth international conference on advanced semiconductor devices and microsystems - asdam 04' under Sixth Framework.

assistant: **Concept**

The ASDAM Conference is being organized every second year since 1996 in Smolenice, Slovakia. During this period the Conference developed to one of the most famous and important semiconductor meetings at minimum in the Central European region. The Conference is organized alternately by the Institute of Electrical Engineering of Slovak Academy of Sciences and Faculty of Electrical Engineering and Information Technology of Slovak University of Technology in Bratislava. The Conference is devoted to the latest results of the research and development in the field of semiconductor nanodevices and microsystems. Its goal is to bring together leading experts from European Union Member States and from Associated Candidate Countries. In the Conference also the scientists from the New Independent States of the former Soviet Union take part. The proceedings of the ASDAM 96 Conference was published in re-known journal Solid-State Electronics. Proceedings of the following meeting were published by the Institute of Electrical and Electronics Engineers, Inc. - IEEE. Also the Conference ASDAM 04 will concentrate on the following topics: *Materials and nanotechnologies *Nanostructures and nanodevices *Modelling and characterization *Micro(nano)electromechanical systems. The Conference will be held from October 17th to October 21st 2004 in Smolenice Castle, Slovakia. Each Conference topic will be introduced by a leading European expert in the field. Besides invited talks there will be ten plenary and two poster sessions to illustrate the state-of-the-art and indicate future trends for every discussed topic.