RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Virtual control methods for coupling heterogeneous problems' under Seventh Framework.

assistant: **Concept**

In this project we aim at addressing mathematical and numerical methods based on virtual controls for the coupling of heterogeneous problems described by partial differential equations.These problems arise in many practical applications. For example, whenever different phenomena have to be taken into account in two or more subregions of the computational domain, or when, for the description and simulation of complex physical phenomena, combinations of hierarchical mathematical models are set up with the aim of reducing the computational complexity.In both cases, we have to study a multiphysics problem, i.e. a system of heterogeneous problems, where different kind of differential problems are defined in different subregions (either disjoint or overlapping) of the original computational domain.Virtual control is a powerful technique based on the optimal control theory that has been introduced in domain decomposition method with overlapping subdomains to treat homogeneous problems, either elliptic and parabolic.The basic idea of this approach consists in introducing suitable functions called ``virtual'' controls  which play the role of unknown boundary data on the interfaces of the decomposition and in minimizing in a suitable norm the difference between the solutions of the subproblems on the overlap.In this project we aim at extending the virtual control method for a class of heterogeneous problems considering both analytical and computational aspects. In particular, we will characterize suitable functionals to be minimized on the overlapping regions in order to ensure both the well-posedness of the problem and a correct description of the physical phenomena of interest. Moreover, we will focus on the development of effective numerical methods and preconditioning techniq
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Metabolic consequences of mitochondrial dysfunction' under Seventh Framework.

assistant: **Concept**

This proposal aims to clarify mitochondrial contribution to obesity and thinness, using carefully characterized mitochondrial disease and obese patient materials, and genetically modified disease models. Manifestations of mitochondrial respiratory chain (RC) defects range from infantile multisystem disorders to adult-onset myopathies or neurodegeneration, and even aging-related wasting. Why defects in oxidative ATP production can lead to such variety of manifestations and tissue specificity is unknown. We have previously identified a number of gene defects that lead to RC disorders. In addition to neurological symptoms, these patients often show various metabolic manifestations:  specific gene defects associate with short stature and thinness, whereas others with metabolic syndrome or obesity. This implies that specific mitochondrial defects can have opposing effects for fat storage or utilization. The involved pathways may contribute to mitochondrial disease progression, but are unknown.We propose to a) undertake a major clinical study on genetically defined, obese or thin, mitochondrial patients, and examine their metabolic phenotype in finest detail. These data will be compared to those from normal obesity, to search for common mechanisms between mitochondrial and general obesity. b) generate a set of disease models for mitochondrial disorders associated with obesity, and knock-out models for specific signallers for crossing with the disease models. c) identify in detail the involved regulatory pathways, and utilize these for searching chemical compounds that could modulate the response, and have therapeutic potential. The project has potential for major breakthroughs in the fields of mitochondrial disease pathogenesis and treatment, neurodegeneration and obesity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Designer Quantum Materials Out of Equilibrium' (AlterMateria), addressing dissemination and exploitation.

assistant: **Impact**

Recently, ‘designer’ quantum materials, synthesised layer by layer, have been realised, sparking ground-breaking new scientific insights. These artificial materials, such as oxide heterostructures, are interesting building blocks for a new generation of technologies, provided that one is able to access, study and ultimately control their quantum phases in practical conditions such as at room temperature and high speeds.On the other hand, an independent research area is emerging that uses ultra-short bursts of light to stimulate changes in the macroscopic electronic properties of solids at unprecedented speeds. Here I propose to bridge the gap between material design and ultrafast control of solids. This new synergy will allow us to explore fundamental research questions on the non-equilibrium dynamics of quantum materials with competing ground states. Specifically, I will utilize intense THz and mid-infrared electromagnetic fields to manipulate the electronic properties of artificial quantum materials on pico- to femto-second time scales. Beyond the development of novel techniques to generate THz electric fields of unprecedented intensity, I will investigate metal-insulator and magnetic transitions in oxide heterostructures as they unfold in time. This research programme takes oxide electronics in a new direction and establishes a new methodology for the control of quantum phases at high temperature and high speed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Identification and characterisation of novel WWP2 substrates and their role in chondrogenesis and osteoarthritis' (ChondUb), addressing dissemination and exploitation.

assistant: **Impact**

Osteoarthritis (OA), characterised by cartilage degradation, is the most common form of arthritis affecting >10% of the EU population over 60 years of age. The pathogenesis is only poorly understood. There is no cure available and current treatment involves pain relief and joint replacement surgery. WWP2 is an ubiquitin ligase involved in stem cell differentiation, cancer development and immune responses, and importantly plays crucial roles in chondrogenesis and craniofacial development. However, its role in cartilage biology and OA development has not been elucidated. Ubiquitination regulates most signalling pathways and cellular processes. Previously, I have shown that ubiquitination plays a role in OA development. Here I aim to identify and characterise WWP2 substrates using a combination of novel techniques. In addition, I will investigate the role of WWP2 and its substrates in cartilage biology with the goal to uncover molecular targets for OA treatment and other WWP2-related diseases. The project is aligned with the “Health, Demographic Change and Well-Being” and “Understanding disease” challenges of Horizon2020.The work will be performed under supervision of Dr Weissman, Chief of the Laboratory of Protein Dynamics and Signaling at the National Cancer Institute (US) and at “EULAR Centre of Excellence” at Newcastle University (UK) under supervision of Prof Young. Dr Weissman has an excellent track record in ubiquitin ligases biology and development of drugs targeting them and Prof Young in cartilage biology and mouse models of OA. Therefore, both groups are highly complementary for this project and envisage future collaborations arising from this fellowship.During this multidisciplinary project I will acquire new knowledge and will reinforce my research skills by l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enabling Precision Immuno-oncology in Colorectal cancer' under Horizon 2020.

assistant: **Concept**

Immunotherapy with checkpoints blockers is transforming the treatment of advanced cancers. Colorectal cancer (CRC), a cancer with 1.4 million new cases diagnosed annually worldwide, is refractory to immunotherapy (with the exception of a minority of tumors with microsatellite instability). This is somehow paradoxical as CRC is a cancer for which we have shown that it is under immunological control and that tumor infiltrating lymphocytes represent a strong independent predictor of survival. Thus, there is an urgent need to broaden the clinical benefits of immune checkpoint blockers to CRC by combining agents with synergistic mechanisms of action. An attractive approach to sensitize tumors to immunotherapy is to harness immunogenic effects induced by approved conventional or targeted agents.Here I propose a new paradigm to identify molecular determinants of resistance to immunotherapy and develop personalized in silico and in vitro models for predicting response to combination therapy in CRC. The EPIC concept is based on three pillars: 1) emphasis on antitumor T cell activity; 2) systematic interrogation of tumor-immune cell interactions using data-driven modeling and knowledge-based mechanistic modeling, and 3) generation of key quantitative data to train and validate algorithms using perturbation experiments with patient-derived tumor organoids and cutting-edge technologies for multidimensional profiling. We will investigate three immunomodulatory processes: 1) immunostimulatory effects of chemotherapeutics, 2) rewiring of signaling networks induced by targeted drugs and their interference with immunity, and 3) metabolic reprogramming of T cells to enhance antitumor immunity. The anticipated outcome of EPIC is a precision immuno-oncology platform that integrates tumor o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Trento 2001'.

assistant: **Innovation**

Trento 2001 is focussed on the applications of both concepts and methods based on light -front quantization of field theories to the description of several different phenomena ranging from nuclear to particle physics with a possible generalization to the theory of extended objects (strings, branes). The event belongs to a well-established series of international workshops and meetings, originated in Heidelberg in 1991. Those conferences usually took place in Europe or U.S. Besides fostering the traditional topics; Trento 2001 aims at opening the subjects to other scientific communities working in related area like lattice gauge theory and strings. It will gather both outstanding senior experts, who will deliver general introductory talks, and skilled young people mostly from EU, with a chance of presenting and discussing their work.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Unique technology to turn on-site paper waste from the printing industry into high-quality PHA bioplastic' to be submitted under Horizon 2020.

assistant: **Abstract**

PAPER-P is a novel technology to synthetize very high quality PHA bio-plastics (98% purity) from on-site paper waste. Through an extremely cost-effective process, PAPER-P is the unique technology able to use as rough material printed waste, waste solvent and ink, with a price of €0.1/Kg, and transform it into PHA, a 60 times more valuable product worth €6/Kg, thus quadruplicating printers’ ROI, from current 2-8% up to 30%.Thanks to Mr. Giacomelli, CEO of BIO-PRO with more than 27 years of experience in the sector, this Italian SMS has developed PAPER-P in collaboration with Bologna University, as a strategic approach to find new markets for the printing industry, currently experiencing a severe decline.European PHA packaging market is forecasted to reach €25 million by 2018, the highest among bioplastics, with an impressive 25% growth. By contrast, PHA production in Europe is marginal in a global market dominated by China and US (90%).BIO-PRO has developed a tested a TRL6 prototype plant processing 400 kg/year of paper waste. Full integration & automation (turn-key), and upscale to industrial rates (4,000 ton/year) are next steps of project development to TRL9.We have the support from our main key stakeholders: Coptip IndustrieGrafiche (printer), Softer Group (plastic compounder), Loacker SpA (food sector) and COOP Italy (large retailer).BIO-PRO revenue will be increased to €16.5 million with accumulative profit of €3.8 million in 2021. BIO-PRO will incorporate at least 8 new employers. At the same time, PAPER-P will increase 30% the ROI of its first end-users, printing industries, but non-recyclable paper (greasy paper or already recycled paper with short fibbers), can also be converted in PHA by PAPER-P, so the recycler’s sector is a second big potential market that B
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Meet and learn What Excellent science does FOR YOU and the society' (WeForYou) targeting Horizon 2020.

assistant: **Abstract**

Meet and learn What Excellent science does FOR YOU and the society is the major focus of the coordinated WeForYou action in performing the European Researchers’ Night 2014 and 2015 in Slovenia. Energy research & innovation, Environment & Climate Action, Health and ICT Research & Innovation are the priorities which will be tackled by a series of actions and opportunities for interchange of knowledge in the European Researchers’ Night 2014 and 2015 in Slovenia.The events in 2014 and 2015 in Slovenia will take place in: - Ljubljana, the main city square organized by Jožef Stefan Institute (JSI);- Novo mesto, organized by Faculty of Information Studies;- Piran and Piran bay, organized by National Institute of Biology;- Planica, Planetary Habitat Simulation Centre organised by JSI;- Krško, organized by Jožef Stefan Institute (JSI)The European Researchers' Night aims to bring researchers to the general public and to increase awareness of research and innovation activities, with a view to support the public recognition of researchers, creating an understanding of the impact of researchers' work on citizen's daily life, and encouraging young people to embark on scientific careers. Among the goals of WeForYou is one of special importance - presenting the researchers that have shown excellency in their results and achievement as ordinary people. Activities that are planned will enable the wide public audience to identify itself with the researchers’ life and to promote science in a firm expectation that the passed message to the young people will embark them on scientific careers. Children and adults addressed within the WeForYou activities will have the opportunity to understand science by experiencing its day-to-day practices, by frequenting the spaces and places where research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Wind turbine blade erosion with particle-laden atmospheric flow'.

assistant: **Objectives**

Wind energy is essential to achieve carbon neutrality and the sustainable society. Optimization of its operations and maintenance (O&M) is imperative for its economic viability. Current annual O&M costs in Europe are around 5.8 billion euros, with erosion due to particle collisions being a significant contributor. This research aims to develop an innovative wind turbine monitoring system that integrates a novel stress sensor with a comprehensive understanding of turbine blade stress induced by particle-laden atmospheric turbulent flow. Three objectives guide this interdisciplinary study: (1) To adapt a novel stress sensor for aerodynamic applications, (2) To elucidate the fundamental mechanisms behind particle-induced stress on turbine blades, and (3) To create turbine blade damage maps that relate to actual operational and weather conditions. The project leverages state-of-the-art facilities for turbulence studies and the ultrahigh-sensitive strain sensor. First, the ultrahigh-sensitive sensor is redesigned for aerodynamic application. Particle-ladenatmospheric flows are then created in the lab to measure the distribution of particles in the flow around turbine blades and thestresses they impose on them. The fluid dynamic mechanisms that determine particle concentration and particle-inducedstresses on turbine blades are examined and an analytical model is established. To improve field applicability, the independentvariables of the model are replaced by operational and weather condition parameters that can be easily measured in the field. Finally,the practicality of the study is confirmed by creating annual damage maps of wind turbine blades operating in Europe and comparingthem with turbine blade lifetime and maintenance cycle data. The project not only brings to light
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Collective Research ERA-NET II'.

assistant: **Innovation**

The principal objectives of CORNET II are to broaden, deepen and sustain the trans-national cooperation between programmes supporting Collective Research and thereby to build the CORNET brand. More specifically, our objectives are to: - establish a long-term sustainable structure for a continuously strengthened and extended collaboration on Collective Research across Europe (WP1); - increase the number of CORNET Calls for Proposals, their budgets, the number of funded projects etc. as well as ensure coordination with similar initiatives, e.g. the Framework Programme’s Research for SME Associations and the EraSME ERA-NET (WP2); - further expand the CORNET consortium to integrate new partners (WP3); - and to disseminate and communicate the benefits of Collective Research to all stakeholders (WP4). CORNET II will therefore consolidate the achievements of CORNET I. It will focus on the long-term strategic positioning and institutional anchoring of CORNET in the European Research Area, while strengthening joint operational activities, especially joint Calls. The core STRATEGIC GOALS of CORNET II by the end of the project are to: - achieve a sustainable state of integration among the CORNET partners in relation to the scientific, managerial and financial dimensions of joint programme management, including an appropriate form of common formal organisation, and  - position CORNET long-term in the European Research Area, notably in dialogue with and in relation to the Framework Programme’s Research for SME Associations, including the possibility of becoming in time the principal or even sole vehicle for funding transnational Collective Research projects at European level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'FUNctional GLASS'.

assistant: **Objectives**

The scientific objective of the project FUNGLASS- FUNctional GLASS integration in photonic devices and components- addresses one of the most crucial challenges in research and innovation which lies in the design and manufacturing of optical components and systems. Among the materials used in photonic devices, glasses play a central role: they are used as laser sources, lenses, smart screen, optical fibers and specialty fibers to name a few.  FUNGLASS breakthrough relies on the control of nano/micro processing and 3D printing of glass by laser writing or poling, offering extraordinary opportunities for fabrication of elementary building-blocks such as multimaterial optical fibers with unique topology, morphology and novel properties for the design of integrated multifunctional components and devices.FUNGLASS proposes interdisciplinary European scale staff exchange programme with unique positioning on laser/field 3D nano/micro patterning and functionalizing of novel photonic glass materials allowing fabrication of sophisticated components and systems on their own. The involvement of large international centers with state of the art facilities for developing photonics components will enable provision of the required skills for developing a career in the private sector, as an entrepreneur, a CEO, a chief of R&D department etc. The involvement of international experienced and recognized professors, ER, involved in the project will also ensure that ESRs are prepared for a career in research excellence. Moreover, the strong lasting links between those centers allow the popup for an unpreceded international network in photonics and material. This proposal will contribute to sustain this network by the creation of joint unit laboratory between participants.


**Keywords:** Glass