RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Impact of yolk-cellular blastoderm-egg shell interactions on the evolution of animal gastrulation' (GHOSTINTHESHELL).

assistant: **Concept**

Early animal development, including the process of gastrulation, exhibits tremendous diversity of morphogenetic mechanisms. How does this morphological divergence evolve under the constraints imposed on early embryos remains unclear. In this proposal, I will ask how interactions between cells of the early embryo, the yolk component of the egg and the attachment to the surrounding egg shell affects gastrulation morphogenesis. I will focus on the comparison of two insect embryos, Drosophila and Tribolium, that exhibit strikingly different flows and foldings of the fundamentally very similar cellular blastoderm epithelium during gastrulation. I will ask how contacts between the cellular blastoderm, the yolk-sac and the surrounding vitelline envelope confine and shape tissue movements. What are the molecular mechanisms mediating the contacts and what functional consequences their disruption has for the embryo’s viability. I will probe the tissue interactions by embryological and biophysical manipulations, in toto electron and live microscopy and through genetic manipulations of the integrin adhesion pathway that I recently showed to impact insect gastrulation by mediating cellular blastoderm-vitelline envelope attachment. Using the comparative approach, I will ask how changes in the regulation of tissue interactions sculpt gastrulation morphogenesis in these insect species. I will then expand the investigation beyond arthropods and probe the tissue-shell interaction in several non-model species in order to understand its evolutionary origin and significance for shaping animal phylogeny. Taken together, the research will bridge two relatively isolated disciplines – evolution of development and tissue morphogenesis. By combining their methodological and conceptual approach, I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Accreting millisecond X-ray pulsar dynamics', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

We intend to study, for the first time, the role that neutron star (NS) interior physics and gravitational wave (GW) torques have in the spin evolution of accreting millisecond X-ray pulsars (AMXPs). Accreting NSs, and AMXPs in particular, are one of the most interesting laboratories to study the physics of compact objects and a potentially interesting source of GWs. There is, however, currently a lively debate on the interpretation of apparent spin variations in these systems and without further theoretical work and a more solid understanding of the torque acting on the NS no progress can be made. NSs are a complex multi-component system, and it is well known that GW emission and the details of the interior physics will play a role in the spin evolution. However this effect has not been quantified, even though there are ongoing efforts to study the details of the magnetized accretion flow in the exterior. This is clearly a catastrophic omission. Through this project we intend to fill this scientific gap and aim to understand which GW emission mechanisms are compatible with the observed X-ray flux and pulse arrival time variability in AMXPs, and what kind of observable electromagnetic signature they would produce. We shall consider in detail the role that GW torques due to crustal asymmetries and unstable r-modes (fluid modes of oscillation governed by the Coriolis force) have on the spin evolution and study their signature in the quiescent thermal X-ray emission. Furthermore we shall study the effect that superfluidity, and the crust core coupling in particular, have on the NS’s response to a varying accretion torque in order to determine whether the proposed emission mechanisms (mountains and r-modes) are compatible with the observed fluctuations in the X-ray timing d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Microbial Desalination for Low Energy Drinking Water' (MIDES), addressing dissemination and exploitation.

assistant: **Impact**

Shortage of fresh water has become one of the major challenges for societies all over the world. Water desalination offers an opportunity to significantly increase the freshwater supply for drinking, industrial use and irrigation. All current desalination technologies require significant electrical or thermal energy, with today's Reverse Osmosis (RO) desalination units consuming electric energy of at least 3 kWh/m3 – in extensive tests about ten years ago, the Affordable Desalination Collaboration (ADC) in California measured 1.6 kWh/m3 for RO power consumption on the best commercially available membranes, and total plant energy about twice as high. To overcome thermodynamical limitations of RO, which point to 1.09 kwh/m3 for seawater at 50 % recovery, Microbial Desalination Cells (MDC) concurrently treat wastewater and generate energy to achieve desalination. MDCs can produce around 1.8 kWh of bioelectricity from the handling of 1 m3 of wastewater. Such energy can be directly used to i) totally remove the salt content in seawater without external energy input, or ii) partially reduce the salinity to lower substantially the amount of energy for a subsequent desalination treatment. MIDES aims to develop the World’s largest demonstrator of an innovative and low-energy technology for drinking water production, using MDC technology either as stand-alone or as pre-treatment step for RO.The project will focus on overcoming the current limitations of MDC technology such as low desalination rate, high manufacturing cost, biofouling and scaling problems on membranes, optimization of the microbial-electrochemical process, system scaling up and economic feasibility of the technology. This will be achieved via innovation in nanostructured electrodes, antifouling membranes (using na
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Viscoelastic and elastoplastic damage behaviour of filament winding composite shells under multiaxial static and dynamic loads' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The goal of this study is a contribution to render the Filament Windin Technology a manufacturing process for primary composite parts, by increasing the characteristics and predicting the damage behaviour of manufactures through theoretical modelling and numerical simulation. What will be considered is the elastoplastic and viscoelastic damage behaviour for different load configurations, as internal-external pressure and traction-compression loads, by developing a theoretical-numerical model. In this way, it will be possible to increase the reliability of these materials by controlling their global behaviour under realistic working conditions. Moreover, by considering damage and manufacturing defects it will be possible to control their influence upon the mechanical characteristics of the structure.  With this study it could be possible to predict the residual life of a damaged structure in order to avoid catastrophic crashes, which imply more cost, more lost, and more pain! It will also be possible the minimisation of scraps during the production cycle, which implies less production cost, and consequently lower price for the consumer.  The applications of this study are numerous: whole composite aircraft, considering that composite structures are extremely light; big tanks for liquid transportation applications, considering their high resistance to corrosion, and also tubes for drinkable water; fishing rods for their big flexibility and resistance; composite car bodies for a combination of characteristics and a very high surface finishing, e.t.c.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nonlinear Rock and Roll - Modelling and Control of Parametric Resonance in Wave Energy Converters' under Horizon 2020.

assistant: **Concept**

The title of this project is ‘Nonlinear Rock and Roll – Modelling and Control of Parametric Resonance in Wave Energy Converters’.  The over-arching aim is to catalyse increased research into parametric resonance (PR) within wave energy and other offshore renewable energy fields. The concept of resonance is well known in the study of wave energy converters (WECs). In comparison, PR has received virtually no attention, and is often unexpected since it is a nonlinear phenomenon not predicted by the linear/frequency domain models traditionally favoured in WEC research and analysis. Whereas normal resonance causes the oscillations of a system to grow linearly with time, PR causes an exponential increase in oscillation amplitude, and therefore has great potential to be either detrimental or beneficial to a WEC performance. For certain classes of WECs, PR can lead WEC instability and decreased performance, by transferring energy from the primary mode of motion into other modes. Alternatively, for other types of WECs designed to extract power from the parametrically resonating modes of motion, triggering PR could result in increased energy capture and represent a game-changing approach to improving WEC performance.To achieve the over-arching goal, the project focuses on the following  specific objectives:1) Demonstrate novel control techniques to either mitigate or harness PR for different classes of WECs.  2) Provide opensource tools for modelling and analysing PR in WECs, to aide the wave energy community in overcoming the barriers surrounding the advanced nonlinear methods required to investigate PR.  3) Strong communication, dissemination and exploitation activities. Providing information to the wave energy community and connections with  researchers from other disciplines
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Implementation of the Strategy to Ensure the EMSO ERIC’s Long-term Sustainability' (EMSO-Link).

assistant: **Innovation**

EMSO-Link is a 3-year project underpinning the long-term sustainability of EMSO ERIC, the pan-European distributed Research Infrastructure (RI) composed of fixed point open ocean observatories for the study and monitoring of European seas. EMSO pursues the long-term objective to be part of the upcoming European Ocean Observing System (EOOS), which is expected to integrate multiple platforms and data systems, including other ERICs, to achieve the first sustained, standardized and permanent observatory network of the European seas. EMSO ERIC coordinates the access to the facilities and supports the management of data streams from EMSO observatories. EMSO-Link will accelerate the establishment of EMSO ERIC governance rules and procedures and will facilitate the coordination of EMSO infrastructure construction, operation, extension and maintenance. Specifically, EMSO-Link will:1.Reinforce and expand the EMSO ERIC membership to optimize the inclusion of the whole European Marine technology and research institutions.2.Progress towards coordinated operations of the infrastructure nodes, interoperability and standardization as well as capacity increase and synchronizing funding of regional nodes.3.Enhance stakeholders (e.g., marine operators, industry, academia, universities and marine experts) activeengagement through a number of awareness raising campaigns. 4.Enhance relations with sister marine initiatives and counterpart/complementary RIs through Memoranda of Understanding also in coordination with COOP+ EC Project. 5.Strengthen EMSO ERIC contribution to European economic growth and innovation through implementation of a powerful marine technologies Innovation Platform serving and cooperating with Industry and SMEs.EMSO-Link will contribute to the identification of methodol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A treatment planning model for targeted radionuclide therapy' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Targeted radionuclide therapy (TRT) has been used as a systemic treatment modality for a range of cancers for 70 years. Its use will increase in Europe as new treatments are introduced into the clinic. However, quantitative analysis of energy deposition ha s seldom been carried out, and treatment strategies vary widely between centres. Internal dosimetry is becoming increasingly necessary to fully assess and compare treatment strategies.This project will develop methodologies to formulate treatment planning for TRT, as is carried out routinely for external beam radiotherapy, and as is required by a recent European directive. Two main aspects will be considered; internal dosimetry and fractionation administration. Techniques for cellular dosimetry will be expl ored and the absorbed doses at this scale will be calculated for radionuclides used for therapy. This information is necessary to help determine the optimal radionuclides to treat patients with metastatic spread and minimal residual disease.At present the number and level of radioactive fractions administered for any given therapy varies widely across Europe. The methodology to quantitatively analyse and compare fractionation options will be developed, and the relevant parameters will be examined in isolati on and in terms of their interactions. An accurate method to compare absorbed doses with successive treatments will be developed to enable treatment to be monitored and modified as it progresses.Results from the internal dosimetry and the fractionation stu dy will be used to form a theoretical and computational model for treatment planning. This model will be applied to clinical data acquired from I-131 mIBG therapy for adult and paediatric neuroendocrine disease and Y-90 monoclonal antibody therapy of lymph oma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pulse Charging for Lithium Metal Solid-State Batteries' (PulseLiSSBs).

assistant: **Concept**

Lithium metal solid-state batteries (LiSSBs) are promising candidates for next-generation batteries due to their high energy density and non-flammable nature. They hold promise for accelerating the storage of clean energy sources like tidal, wind, and solar energy, as well as advancing the development of electric vehicles. Pulsed current charging is expected to extend battery lifetime and enhance safety. Although some reports have pointed this out, the lack of comprehensive mechanistic understanding and electrochemical model development makes it difficult to draw scalable conclusions or determine the optimal frequency of pulse charging.The primary goal of this proposal, Pulse Charging for Lithium Metal Solid-State Batteries (PulseLiSSBs), is to extend the lifetime of LiSSBs by optimizing the battery charging protocols. This requires first understanding the internal electrochemical mechanisms under pulse charging and studying the impact of pulsed current on the lithium metal anode interface, contact impedance, and dendrite growth through experiments and electrochemical modelling. Finally, by simulation, the optimized parameters for pulsed current frequency and duty cycle will be selected.PulseLiSSBs project will be executed by experienced researchers who will work closely with a supervisor with a strong background in battery mechanism analysis, electrochemical modelling, and charging strategies. The fellow will also benefit from the research team's experience in Denmark and Germany, where Denmark has a robust battery testing research group, and Germany has a strong team focused on battery mechanism analysis. The project aligns with the Horizon Europe mission and can contribute to the EU's 2050 Climate-neutrality Goals and the United Nations' Sustainable Development Goals
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Clinical Trials Community Africa Network' to be submitted under Horizon Europe.

assistant: **Abstract**

With over 25% of the global disease burden, only 3% of global clinical trials occur in Africa. This disproportion is driven by inadequacies in clinical research capacity, regulatory process ambiguity, deficient regional patient and disease area data, and lack of visibility of existing clinical research capabilities in Africa. To address this disproportion, this proposal seeks to establish the Clinical Trials Community Africa Network (CTCAN), a collaborative framework of key clinical research stakeholders in the African region, pharma partners, and other relevant international stakeholders, with the overarching goal of bringing more clinical trials to the region in a sustainable and coordinated manner. This collaboration will map and draw on the experience and expertise of already existing networks and initiatives. It will create a network of subnetworks that will foster coordination in clinical research, by ensuring and encouraging alignment in disease area prioritization, raising awareness and visibility of existing capacity from sites and labs across Africa, operationalising the regulatory processes across the region, and strengthen less experienced sites and labs through a clinical trial preparedness framework, while encouraging inter- and cross-continental knowledge and expertise sharing. CTCAN will use and expand the Clinical Trials Community (CTC) platform, an electronic platform consolidating data on researchers, regulations, sites, and epidemiology across the continent. The result will be an ever-present and ready-to-go pool of clinical research sites and labs with the agility to rapidly address new and emerging global health threats, epidemics, and pandemics, thereby efficiently contributing towards clinical research in pandemic preparedness. CTCAN will lay the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integration of advanced aerodynamics in comprehensive rotorcraft analysis' (ROSAA).

assistant: **Concept**

Objectives and content:The primary objective of this proposal is to develop a unique integrated rotorcraft simulation system for the improved analysis of the aerodynamic, aeroacoustic, and aeroelastic performance of rotors. There is a strong industrial need within the European rotorcraft community for a unique rotorcraft simulation system able to integrate advanced aerodynamics codes with the comprehensive aeroelastics codes available to European manufacturers in order to incorporate more accurately the aerodynamics of advanced rotors in global simulations. The advanced aerodynamics codes will also provide the high quality aerodynamics data needed by the latest generation aeroacoustics codes. In order for the European Rotorcraft community to compete against its US counterpart, advanced aerodynamic, aeroacoustic and aeroelastic codes have to be integrated in an efficient and user-friendly simulation system. This is the only solution, which will allow Europe to keep an important share of today's global rotorcraft market. At the end of this collaborative research, there will be a significant improvement in the capabilities of the European rotorcraft manufacturers to design and analyse configurations. The simulation system will allow the designer to efficiently examine effects due to changes in the geometry upon the aerodynamic, aeroelastic and aeroacoustic performance of a rotor from within an integrated and user-friendly environment. Furthermore, such a capability will allow the design of next-generation rotors having: improved pilot control loads, reduced vibratory loads, increased speed and lower noise emission. The proposed research on the joint development of an integrated rotorcraft simulation system will further improve the European collaborative technology research