RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Extending the process limits of laser polymer welding  with high-brilliance beam sources' to be submitted under Seventh Framework.

assistant: **Abstract**

PolyBright will develop high power high brilliance lasers with new wavelengths between 1500 and 1900 nm which are adapted to the absorption properties of polymers. With innovative beam manipulation systems for optimum adaption of energy, the project will provide high speed and flexible laser manufacturing technology to expand the limits of current plastic part assembly. Key innovations of the PolyBright project are high brilliance mid-IR-wavelength fibre and diode lasers with powers up to 500 W, high speed scanning and flexible beam manipulation systems, such as dynamic masks and multi kHz scanning heads. New laser polymer joining processes for optimized thermal management in combination with wavelength adapted polymers and additives will provide higher quality, high processing speed up to 1 m/s and robust manufacturing processes at lower costs. Compact lasers with very high beam quality and free form beam shaping will enable reconfigurable assembly machines, offering high productivity with sub second cycle times and unique flexibility for varying joining geometries. The project covers the whole process chain for laser based plastic part assembly and includes laser companies, optics suppliers, material and processing specialists as well as machine suppliers. The developed machine equipment and the new laser process approaches will be validated by end users from medical, consumer good, automotive and watch industry. With this initial step, PolyBright will break new paths in processing of advanced plastic products overcoming the quality and speed limitations of conventional plastic part assembly. PolyBright will thus open new markets for laser systems with a short term potential of over several 100 laser installations per year and a future much larger market share in a mu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Microfluidics-assisted synthesis of Dapagliflozin-loaded liposomes for heart fibrosis: Development of a 3D bioprinted multicellular in vitro model' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, with half of CVDs deaths being caused by coronary artery disease. Myocardial infarction is the most common cause of cardiac insufficiency, leading to fibrosis and ultimately heart failure. Since current therapies for cardiac fibrosis have limitations, there is a need for more effective strategies. Gliflozins (e.g., Dapagliflozin and Empagliflozin), hypoglycemic agents and SGLT2 inhibitors usually used for the treatment of type 2 diabetes, have been shown in recent clinical trials (i.e., DAPA-HF, DELIVER, EMPEROR-Reduced, EMPEROR-Preserved) to reduce the combined risk of cardiovascular death or hospitalization for heart failure in patients with reduced and preserved ejection fraction, regardless of diabetes status. They have also been shown to ameliorate myocardial fibrosis post-ischemia. Nevertheless, most of the underlying mechanisms of these benefits remain elusive and the potential adverse effects of the systemic administration of gliflozins must be recognised. In this regard, the use of liposomes as in situ injectable drug delivery systems offers many potential advantages for the therapy of myocardial infarction. Therefore, the SAVETHEHEART project aims to develop a new therapeutic approach for the efficient treatment of cardiac fibrosis by using liposomes, produced by microfluidics to encapsulate Dapagliflozin (DAPA). Their effect will be studied in a 3D model of cardiac fibrosis, that will be obtained by bioprinting a biomimetic type I collagen hydrogel, bioengineered with human induced pluripotent stem cells-derived cardiomyocytes, myofibroblasts and endothelial cells, and cultured under perfusion and hypoxic conditions to better mimic a fibrotic response. Understanding cell behaviour in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Three-dimensional kinematic modelling of ductile shear zones: towards an unified theory of shear sense indicators' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content continue observation in the uterus. Handicap and death may result from either course and there are no unbiased data to inform borderline decisions, so policies vary widely. Randomised controlled trials are required, and since November 1994 the UK Medical Research Council has been funding the pilot phase of one, the Growth Restriction Intervention Trial (GRIT). This is a pragmatic trial with clinician uncertainty (equipoise) as the main entry criterion. The primary outcome measures are survival and developmental quotient at two years of age, and analysis will be stratified by both the gestational age at entry and the degree of abnormality of the umbilical artery Doppler flow velocity waveform. The recruitment target in the UK was 900 subjects over 5 years, but recruitment has been slow because clinician equipoise has been less common than was anticipated. A number of European centres have expressed interest in joining GRIT and we propose to link them in a Concerted Action. This will increase recruitment. It will also increase generalisability, since thresholds for delivery vary around Europe. During the concertation we will also collect the results of automated analysis of CTG variability before randomisation. This will facilitate recruitment for clinicians presently managing patients this way and permit stratification for analysis based on this variable. The main Concertation target is the recruitment of 250 subjects to GRIT over three years.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Increased service lifetime of forging tools by combined surface treatments (FORBEST)'.

assistant: **Concept**

Nitriding of forging tools is a well known technology to extend the service life of the tools due to the higher wear resistance of the nitrided surface layer. A good approach to improve the wear resistance is to combine a laseralloying surface treatment with a subsequently nitriding or nitrocarburising. Main innovation of this surface treatment method is the investigation of new alloy-material compositions regarding the newly-created material properties. Both the influence of laser-alloyed and subsequently nitrided (or nitrocarburised) and the influence of nitrided (or nitrocarburised) and subsequently CMSII treated surfaces will be investigated regarding the surface layer properties and in particular regarding the increase of the service lifetime of the forging tools. The project is divided into three phases: research, development and validation. A strong project management will ensure a successful course of the project and will guarantee a systematic documentation. Research: The composition of the alloy-materials for the laser alloying process and the combination of the surface treatment technologies, which will be investigated in this project, have never been tested before. The basic research will be done on samples with a simple geometry, which will be analysed by metallographic research. Development: The process parameters will be adapted to test forging tools, which will be run under industrial conditions and compared to conventionally treated tools. Based on the results of the investigation of the used tools the process parameters for the surface treatment of new forging tools will be continuously optimised. Validation: In this phase the surface treatment combination will be assessed. At the end of the project a plan about the exploitation of the results will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Compact direct (m)ethanol fuel cell for portable application (MOREPOWER)' (MOREPOWER), addressing dissemination and exploitation.

assistant: **Impact**

The objective is to develop a low-cost, low temperature, portable direct methanol fuel cell device. It will also offer limited operation on ethanol fuel and will be of compact construction and modular design. The development will include novel proton exchange membranes, anode and cathode electro catalysts and fully optimised multilayer membrane electrode assemblies. New low-cost proton exchange membranes will be developed to reduce the methanol crossover rate through the electrolyte to levels significantly lower than that of currently available materials (e.g. Nafion). New electro catalyst materials will be developed to enhance the low temperature methanol (and ethanol) electro-oxidation activity of the anode. Catalyst development for the cathode will focus on enhancing the oxygen reduction activity of platinum electro catalyst and increasing its selectivity to enhance methanol tolerance.The structure of the electro catalyst and electrode layers will be optimised to promote efficient operation at low temperatures with practical flows and pressures. System optimisation, simplification and miniaturization will be carried out. The final performance objectives will be: single cells operating at 0.5V / cell at 0.2 Acm-2 at 30-60 C (in atmospheric pressure air).Prototypes of 100 and later 500 W stacks, operating at low temperatures with aimed electrical characteristics of 40 A/12.5 V, will be the targets of the project. The effective operation at this low temperature is particularly challenging. Additionally a conceptual study for up-scale will be supplied. A narrow collaboration between research centres and industry will make possible a rapid exploitation of the new components and system developments.A SME will be responsible for the integration and will deliver the prototyp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'DemonstratIng Value of agri data sharIng for boostiNg data Economy in agriculture' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Agriculture is being managed more tightly than ever before and is generating more data than ever before, but the potential of a data economy in agriculture remains unexplored. The reasons for this are varied, and include technical interoperability, business relationships between stakeholders, and social acceptability issues around data ownership and market transparency.Individual stakeholders make use of the data they generate at their own particular stage in the agri-food supply chain. However, the sharing of this data with others along the chain and its collective analysis needs more development and demonstration if more efficiencies are to be introduced and further value added to the agri-data economy. While some sharing is taking place on an ad-hoc basis, each new set of potential data sharers must start from scratch and work through the same issues common to all such arrangements. Equally, the lack of data sharing precedents in agriculture inhibits data owners from taking a more exploratory view of the world.Several dimensions must be considered in policy-making if a fully functioning data economy in the agriculture domain is to emerge. Such a multi-disciplinary approach is at the core of the DIVINE consortium, which encompasses technical (agriculture and ICT), markets, and social sciences expertise. It will build an agri-data ecosystem that incorporates existing common agri data spaces while deploying industry-led pilots built on data sharing arrangements, to demonstrate the cost-benefit and added value in sharing agri data. DIVINE will assess its ecosystem at the level of policy impacts, the uptake of digital technologies, and economic and environmental performance.DIVINE will promote its ecosystem and its assessments to technology providers, policy-makers, farm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Trace elements in polar ice cores: Archives and source-of-region apportionment of toxic metals since Holocene'.

assistant: **Innovation**

Among natural archives, ice cores have a special advantage to evaluate historical variations and distinguish natural-anthropogenic sources because ice core has a relatively simple matrix and can supply higher temporal resolution. Many laboratories have devoted a large amount of resources to ice core research and achieved excellent results. However, construction of historic records with source apportionment of metal pollutants for the whole Holocene period from a single ice core has not been done yet due to limitation of technical difficulties and high cost in the previous years. In this project, it is aimed to reconstruct archives and reveal the probable source-of-region(s) and historical variations of Pb and/or Cd from Canadian Arctic ice cores. For this purpose, a series of experiments have been devised with the goal of accurately quantifying the relative contributions of lithogenic and anthropogenic source(s) of Pb and Cd deposited during modern, historical and pre-historical time periods. On accomplishing this project, the following objectives are expected: 1.Archive construction of Pb and Cd for the Holocene period from Devon Ice Cap in the Canadian High Arctic; 2. Retrieval of a possible source-of-region Pb profile for the same time period and from the s ame ice cores with varieties of resolutions; 3. To retrieve a profile(s) of Sc and/or REEs, which could be used for better distinguishing natural source from anthropogenic sources and possibly constructing climate change trend based on climate severity since Holocene; and 4. To develop methodologies and procedures for routinely and precisely but economically analysing Pb isotopes (not including Pb-204), and conservative elements such as Sc and REEs at ultra-low level (pg/g to fg/g level) in snow/ice core samples.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Automatic Design of Robot Swarms', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The scope of this project is the automatic design of robot swarms. Swarm robotics is an appealing approach to the  coordination of large groups of robots. Up to now, robot swarms have been designed via some labor-intensive process.My goal is to advance the state of the art in swarm robotics by developing the DEMIURGE: an intelligent system that is able to design and realize robot swarms in a totally integrated and automatic wayThe DEMIURGE is a novel concept. Starting from requirements expressed in a specification language that I will define, the DEMIURGE will design all aspects of a robot swarm - hardware and control software.The DEMIURGE will cast a design problem into an optimization problem and will tackle it in a computation-intensive way. In this project, I will study different control software structures, optimization algorithms, ways to specify requirements, validation protocols, on-line adaptation mechanisms and techniques for re-design at run time.


**Keywords:** Swarm robotics, automatic design
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Realising two-dimensional heavy fermions in rare-earth intercalated transition metal dichalcogenides' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Quantum materials exhibit unique emergent phases driven by many-body interactions, and a major goal of material science is to harness their properties. Importantly, such materials are sensitive to external stimuli by often being close to quantum criticality, where fluctuations near critical points give rise to phenomena like high-temperature superconductivity and exotic magnetic phases. This opens routes for manipulating and controlling key quantum states. Heavy fermions (HF), characterized by competing magnetic and Kondo interactions, are central to quantum criticality. Dimensionality reduction is an exciting route to control the ground states of HF, as lower dimensions enhance fluctuations and electron correlations. However, the intermetallic nature and thus three-dimensionality of conventional HF make accessing two-dimensional (2D) HF challenging. The project aims to establish intercalated transition metal dichalcogenides (I-TMDCs) as a versatile platform for realizing HF phases in 2D monolayer films.I-TMDCs are ideal for engineering Kondo physics. Their layered structure enables creation of new electronic phases via intercalation. The flexibility in choosing intercalant, host material, and intercalation ratio adds tunability over magnetic and electronic properties, while also providing a route to dimensionality reduction in 2D films. This project will leverage the precision of molecular-beam epitaxy (MBE) in combination with the advanced spectroscopic techniques angle-resolved photoemission spectroscopy (ARPES) and low temperature scanning tunnelling microscopy (STM). Together with theoretical modelling, the methods will offer a comprehensive approach to determining the low energy electronic structure and ground state of I-TMDCs. By building upon conventional I-TMDC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biophysical mechanisms of long-range transcriptional regulation' to be submitted under Horizon 2020.

assistant: **Abstract**

In mammals, transcriptional control of many genes relies on cis-regulatory elements such as enhancers, which are often located tens to hundreds of kilobases away from their cognate promoters. Functional interactions between distal regulatory elements and target promoters require mutual physical proximity, which is linked to the three-dimensional structure of the chromatin fiber. Chromosome conformation capture studies revealed that chromosomes are partitioned into Topologically Associating Domains (TADs), sub-megabase domains of preferential physical interactions of the chromatin fiber. Genetic evidence showed that TAD boundaries restrict the genomic range of enhancer-promoter communication, and that interactions between regulatory sequences within TADs are further fine-tuned by smaller-scale structures. However, the mechanistic details of how physical interactions translate into transcriptional outputs are totally unknown. Here we propose to explore the biophysical mechanisms that link chromosome conformation and long-range transcriptional regulation using molecular biology, genetic engineering, single-cell experiments and physical modeling. We will measure chromosomal interactions in single cells and in time using a novel method that relies on an enzymatic process in vivo. Genetic engineering will be used to establish a cell system that allows quantitative measurement of how enhancer-promoter interactions relate to transcription at the population and single-cell levels, and to test the effects of perturbations without confounding effects. Finally, we will develop physical models of promoter operation in the presence of distal enhancers, which will be used to interpret the experimental data and formulate new testable predictions. With this integrated approach we aim at