RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrating climate impact and spatial microsimulation modelling for improved climate change adaptation decision-making' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Minimising the welfare cost of climate change requires effective adaptation policies. Consequently, the EU strategy on climate change adaptation prioritises the creation of ‘frameworks, models and tools to support decision-making and to assess [the effectiveness of] various adaptation measures’. Accurate measurement of welfare cost is a prerequisite for effective policy prioritisation. The current state of the art quantifies welfare costs using aggregated methodologies. This has been shown to bias cost estimation and does not capture the socioeconomic distribution of welfare impacts. This bias may therefore affect the effectiveness of adaptation measures. Integrating climate impact models (with which Prof Lotze-Campen and the Potsdam Institute for Climate Impact Research [PIK] are experts) with Spatial Microsimulation (SM) modelling (with which the experienced researcher, Dr. Farrell, is an expert) provides a framework to estimate micro-level welfare impacts and thus overcome these deficiencies. Furthermore, this project integrates these estimates into decision-making models to aid policy. This project provides: (1) a timely contribution; (2) a strong multidisciplinary focus; (3) a transfer of SM knowledge to PIK, improving their ability to quantify the welfare impacts of climate change; (4) strong training in climate science and decision-making tools for Dr. Farrell; (5) strong communication/dissemination strategy drawing on resources of Dr. Farrell and PIK.The value of this project is in the collaborative opportunities provided by the research fellowship. PIK provides the best possible opportunities for mentorship and training/professional development for Dr. Farrell. This establishes Dr. Farrell as the leading expert in an emerging field of micro-based welfare estima
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Economic Development and Structural Transformation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The early development literature documented that the growth path of most advanced economies was accompanied by a process of structural transformation. As economies develop, the share of agriculture in employment falls and workers migrate to cities to find employment in the industrial and service sectors [Clark (1940), Kuznets (1957)]. In the first industrialized countries, technical improvements in agriculture favoured the development of industry and services by releasing labour, increasing demand and raising profits to finance other activities. However, several scholars noted that the positive effects of agricultural productivity on economic development are no longer operative in open economies. In addition, there is a large theoretical literature highlighting how market failures can retard structural transformation in developing countries. In particular, financial frictions might constrain the reallocation of capital and thus retard the process of labour reallocation. In this project, we propose to contribute to our understanding of structural transformation by providing direct empirical evidence on the effects of exogenous shocks to local agricultural and manufacturing productivity on the reallocation of capital and labour across sectors, firms and space in Brazil. For this purpose, we construct the first data set that permits to jointly observe labour and credit flows across sectors and space. To exploit the spatial dimension of the capital allocation problem, we design a new empirical which exploits the geographical structure of bank branch networks. Similarly, we propose to study the spatial dimension of the labour allocation problem by exploiting differences in migration costs across regions due to transportation and social networks.


**Keywords:** Economic Deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Redox homeostasis in BRCA1-associated tumorigenesis' (REBAT) targeting Seventh Framework.

assistant: **Abstract**

Mutations of BRCA1 tumor suppressor gene account for 5-10% of hereditary breast cancers. Clinically, BRCA1-mutated cancers represent a unique subtype, with distinctive risk factors and poor prognosis. High-throughput technologies have identified genomic and transcriptomic signatures that are shared by sporadic and BRCA1-mutated breast tumors. BRCA1 mutations have been implicated in other types of tumors such as gastric, pancreatic and prostate cancers. A more detailed picture of BRCA1 tumor suppression functions is needed to design better tailored therapies for these aggressive cancers.BRCA1-mutated tumors tend to accumulate mutations in PTEN and p53 tumor suppressor genes. The current model of BRCA1-related tumorigenesis posits that in BRCA1 mutation carries, the cell of origin bearing BRCA1 mutation at heterozygote status, undergoes loss of BRCA1 wild-type allele and loss or mutation of PTEN and p53 tumor suppressors. Although this intriguing model lacks in vivo evidence, it is widely accepted that PTEN and p53 gene inactivation are required for survival and transformation of BRCA1-mutated cells.BRCA1, PTEN and p53 have been implicated in the regulation of intracellular levels of reactive oxygen species (ROS). Redox homeostasis derives from an imbalance between ROS generation and elimination. Redox homeostasis is crucial in the maintenance of cellular functions and it has implications in tumor development and sensitivity to anti-cancer therapies.This study will investigate the role of PTEN and p53-regulated pathways in affecting the redox homeostasis of BRCA1 null cells. The activity of Nrf2 and FoxO transcription factors that regulate ROS and are related to BRCA1, PTEN and p53 will be considered. These signalling pathways will be analyzed in normal mouse mammary glan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Support to all stakeholders from the Photovoltaic sector and related sectors to contribute to the SET-Plan' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The ETIP PV Secretariat proposal (EUPV+) is designed to re-strengthen the European Technology and Innovation Platform for Photovoltaics (ETIP PV) by implementing a strong and pro-active Secretariat which will provide effective support to the ETIP PV Governance structures and the Working Groups. It will also further work to ensure that the ETIP PV becomes the point of reference for all stakeholders, especially PV industry, but also European and Member State officials. The project shall continue integrating national or regional PV platforms, and strengthening the relations with other organizations supporting the same goals, such as EERA, but also national PV associations and all trade bodies aiming at supporting the development of the European PV industry, not forgetting the other ETIPs.


**Keywords:** Photovoltaics, Solar PV, SET-Plan, local manufacturing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Observational learning in cognitive agents' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The MATHESIS project aims to explore fundamental aspects of social communication and adaptive behaviour, especially the process of assigning meaning to the actions of other subjects. This will be demonstrated by developing and validating artificial cognitive agents, able to acquire a repertory of motor actions by observational learning. Observational learning is understood here as the capacity to acquire an action strategy only through observation of other agents, without the experimentation needed in other learning procedures.Our neurophysiological investigations will attempt to establish that the neural representations of action-execution, action-observation and action-recall overlap extensively within the cortex, as suggested by our preliminary results. A major implication of this, both for biological and for artificial agents, is that it should be possible to train their motor system by simple action-observation and action-recall. The representations, shared by both overt actions and by mentally simulated actions, may account for the traditional use of observational learning and mental training (e.g., the use of videotapes to train athletes).These preliminary results motivate our study of neural network models and robotic cognitive agents, as they learn to control effectors via observation. In contrast to previous such models (based on the mirror neuron concept), which include action recognizing processes on a side path, we intend to use embodied agents to explore the emergence of action recognition in the controllers themselves. Moreover, we intend to examine if observation of action is an efficient means to parametrically adapt a small number of controllers guiding the behaviour of artificial agents.Within MATHESIS we will assess the generality, scalability, accur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Commercial feasibility of a quantitative ultrasound medical device: a patient-specific decision support system for the estimation of dental implant stability' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Dental implants are widely used to replace missing teeth, with more than 4 000 000 implant surgery per year in Europe. Failures still occur because of a bad timing in the implant loading with the prosthesis, inducing pain and increased costs for dental surgeons. Although implant primary and secondary stability is the main determinant of the implant success, it remains difficult to be assessed in clinical practice. OsseoWave is based on the results obtained in the ERC CoG project Boneimplant and aims at developing and validating a medical device consisting in a decision support-system allowing the surgeon to assess dental implant stability. Such medical device is needed by the clinicians in order to adapt their surgical strategy. The objective of OsseoWave is i) to achieve a minimum viable product (MVP) that will be validated in vitro and in vivo, and ii) to investigate its commercial potential and design a subsequent commercial exploitation strategy via spin-off creation or licensing of the technology. The originality of the approach is to use quantitative ultrasound, a non-invasive, non-radiating, portable and cheap technique, which constitute a technological rupture.Regulatory issues will be at the heart of the development and we will work in order to clear the regulatory pathway of the future medical device. Post-OsseoWave, the MVP will be ready to go through CE marking application. The team is constituted by members with complementary skills (including engineers, a business developer and maxillofacial and veterinary surgeons experts in implantology).  OsseoWave will allow the promotion of innovative solution and services in dental implantology. The long-term vision is for the technology to become a reference in dental implant surgery. Strong impacts are associated t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A Personalised Living Cell Synthetic Computing Circuit for Sensing and Treating Neurodegenerative Disorders'.

assistant: **Innovation**

There remain urgent and unmet needs for the treatment of neurological diseases. Epilepsy is a serious, chronic brain disease characterized by recurrent seizures. Closed-loop, implanted devices offer ways to reduce seizures in drug-resistant patients but their efficacy is poor and they interrupt seizures only after they begin. PRIME capitalizes on a breakthrough discovery that transfer RNA (tRNA) fragments, a novel class of noncoding RNA, increase in patients in advance of when a seizure occurs. We propose to engineer human cells to respond to tRNA fragment elevations as the trigger for pre-emptive release of glial-derived neurotrophic factor (GDNF), a seizure-suppressing and disease-modifying treatment. Artificial Intelligence (AI) algorithms will be used to integrate OR or AND logic gate functions in the switching process, depending on the quantity and type of tRNA fragments and timing of their release in a given epileptic network and a second, fail-safe calcium-dependent pathway will allow GDNF release in the event of a breakthrough seizure. This enables a precise level of personalization in the design of the bio-computing cells, which will be encapsulated into a membrane device within the microenvironment scaffold, enabling the engineered cells to co-exist with natural brain tissue. Validation of the bio-computing cells will be tested in both in vitro microfluidic organ-on-a-chip as well as in vivo tests for effects on spontaneous seizures in rodents with epilepsy. PRIME’s results will provide a transformational diagnostic-therapeutic treatment for epilepsy and other neurological diseases that feature disrupted neuronal network function.


**Keywords:** epilepsy, bio-computing logic circuit, molecular communication, biomarker, synthetic biology, autonomous implantabl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Retina-Seal: Gene therapy mediated regulation of the blood retina barrier' (Retina-Seal) targeting Horizon Europe.

assistant: **Abstract**

Age-related macular degeneration (AMD) is the leading cause of irreversible central blindness in the world. The number of people with AMD is predicted to be 288 million by 2040, with an estimated 1 in 10 people over the age of 55 already showing early signs of the condition.    At the inner blood retina barrier (iBRB), claudin-5 is the most enriched component of the tight junctions of endothelial cells, regulating the paracellular diffusion of molecules into and out of the retina. As part of the on-going ERC Consolidator grant Retina-Rhythm, we now have a very large body of data suggesting “leaky” or “CLDN-5 depleted” retinal vasculature drives the accumulation of waste material known as drusen, the hallmark diagnostic feature of AMD. Therefore, methods aimed at enhancing CLDN-5 expression can potentially stabilize vascular integrity and prevent the onset of AMD (both dry and wet AMD). Here, we will develop novel adeno-associated viruses (AAV) that will directly regulate the expression of 2 novel target genes and effectively ""seal"" the blood retina barrier and stabilise disease progression.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'investigating Human Shared PErception with Robots'.

assistant: **Concept**

Perception is a complex process, where prior knowledge is incorporated into the current percept to help the brain cope with sensory uncertainty. A crucial question is how this mechanism changes during interaction, when the brain is faced with two conflicting goals: either optimizing individual perception by using internal priors, or maximizing perceptual alignment with the partner, by limiting the reliance on individual priors. wHiSPER proposes to study for the first time how visual perception of space and time is modified during interaction, by moving the investigation to an interactive shared context, where two agents dynamically influence each other. To allow for scrupulous and systematic control during interaction, wHiSPER will use a humanoid robot as a controllable interactive agent. The research will be articulated along five main objectives: i) determine how being involved in an interactive context influences perceptual inference; ii) assess how perceptual priors generalize to the observation of other’s actions; iii) understand whether and how individual perception aligns to others’ priors; iv) assess how is it possible to enable shared perception with a robot and v) determine whether perceptual inference during interaction is modified with aging, when lowered sensory acuity could increase priors relevance. To these aims wHiSPER will exploit rigorous psychophysical methods, Bayesian modeling and human-robot interaction, by adapting well-established paradigms in the study of visual perception to a novel interactive context. In several experiments the humanoid robot and the participants will be shown simple temporal or spatial perceptual stimuli that they will have to perceive either to reproduce them or to perform a coordinated joint action (as passing an object).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Preparing market introduction of DN-X-PRO - a breakthrough solution for real-time studies of DNA-protein interactions at single-molecule resolution' (PREMADIX) under Seventh Framework.

assistant: **Objectives**

Through ERC-funded research, Prof. Wuite developed the DN-X-PRO as a method and instrument that enables direct visualization of DNA-protein interactions in real-time, at the single-molecule level, at super-resolution, under conditions similar to the cellular environment. Using the DN-X-PRO, researchers can manipulate and measure mechanical and structural properties of DNA-protein complexes, while simultaneously localizing individual proteins on the DNA, with nanometer accuracy and super-resolution. To date, such studies can only be performed by separate application of two or three different instruments, in conditions that do not resemble the cellular environment, with lower resolution. This results in a strong proposition to biomolecular researcher labs worldwide, allowing conduct of a range of experiments that are very complicated or not possible to date.The PREMADIX project will result in a clear valorization strategy — based on elemental business insights that permit estimation of commercial and financial feasibility and business modeling and planning. Besides, a sound intellectual property (IP) strategy will be defined. In parallel, the DN-X-PRO will be physically prepared for marketing, translating the current prototype into a robust and user-friendly design accompanied by product sheets, control and analysis software, and user manuals. Finally, the PREMADIX team will assemble a business team, and start discussions with potential strategic partners and financers. By doing so, at the end of PREMADIX, the team will have strong assets for market introduction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Employees' resources and social rights in europe', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The research analyses changes in employment configuration since the nineties considering employees' resources and related rights in nine countries, articulating national trends and the impact of European integration process. It involves quantitative assessment of resources flows, analysis of institutional settings of entitlements to and management of social benefits, survey of reforms in pensions regimes and active labor market policies, and patterning of population. Moreover, a mapping of the European research area in the field of resources and rights linked to employment and social protection and the set up of a progressive association process with others researchers teams will provide the basis for a European network of excellence.