RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Regularity, uniqueness and qualitative behaviour of degenerate parabolic equations of fourth order' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

In recent years degenerate parabolic equations of fourth order became important for modelling diffusion processes in Physics and Material Sciences. For example, the spreading of viscous droplets on plain surfaces, the phase separation of binary mixtures and the formation of dislocation patterns during plastic deformation are described by equations the archetypus of which is Ut + div(|u|n (triangle, triangle) u) = 0. In one space dimension, Bertsch et al. (BBP, '94) got results concerning regularity, non-uniqueness and qualitative behaviour of solutions. In (G. '94), first results concerning existence and non-negativity in higher space dimensions could be obtained. The objectifives of the project are as follows: ? Optimal results about positivity and evolution of the solution's support in higher space dimensions ? L (infinity)- and C (alpha)- estimates in higher space dimensions ? Formulation of conditions at the free boundary which guarantee uniqueness of solutions (BBP, '94) E.Beretta, M.Bertsch, R.DalPasso: Non-negative Solutions of a Fourth Order Non-linear Degenerate Parabolic Equation, to appear in Arch. Rat. Mech. Anal. (G. '94) G.Grun: Degenerate Parabolic Equations of Fourth Order and a Plasticity Model unith Non-local Hardening to appear in Zeitschrift fuer Analysis und ihre Anwendungen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of GlycoPhage Arrays as a novel high-throughput method for glycomics' (GLYCOPHAGEAPP).

assistant: **Innovation**

Complex carbohydrates (glycans) are attached to proteins and lipids by the process of glycosylation and play important roles in many biological processes including cell-cell recognition, metabolic trafficking and host-pathogen interactions. Altered glycosylation or variations in the synthesis of glycans are known to cause diseases including cancer, retroviral infection and disorders of the heart, lung and blood. In order to establish connections between glycan structures and their functions (functional glycomics), to monitor glycosylation in disease diagnosis and prognosis, and to elucidate molecular mechanisms involved in pathogenesis, the development of precise, robust and sensitive methodologies for glycan analysis is critical. Carbohydrate-based arrays, or “glycoarrays,” have emerged in the last decade as a powerful tool, however to fully exploit the potential of arrays, it will be necessary to (i) increase the quantity and diversity of carbohydrate structures and (ii) develop reliable and reproducible chemistries for the immobilization of the carbohydrate probes onto solid support. Recently, the protein glycosylation locus (Pgl) discovered in Campylobacter jejuni was functionally transferred to E. coli, conferring ability to glycosylate proteins. Additionally, Dr. Celik has recently demonstrated glycosylation of phage particles simply by infecting the glycosylation competent E. coli with M13 phage displaying an acceptor protein. The hypothesis of this particular application is that the presentation of N-glycosylated proteins and O-antigens on phage particles can be exploited for the development of glycan arrays. The study will be significant because it will overcome the current bottlenecks in glycan array construction and provide a relatively inexpensive, specific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quantum Information Learning' in the context of a Horizon 2020 call.

assistant: **Objectives**

This project aims at developing efficient, scalable and near-term-implementable decoders for long-distance communication on free-space or optical-fiber quantum channels. It is a timely proposal for the establishment of high-data-rate space communication and secure fiber communication. Its importance is recognized in the strategic quantum communication pillar of the EU Flagship on Quantum Technologies. In this setting, the main obstacle towards implementations is a joint quantum measurement, impossible with current technology. This project will investigate how to build a complex decoder by combining simple optical gates and photodetectors, augmented by a classical neural network that controls the quantum parameters and post-processes the measurement data. Moreover, it investigates the power of machine learning for quantum technologies, a very recent interdisciplinary field that still lacks killer applications. The applicant has a PhD and several excellent publications on the subject, while the host group comprises world-leading experts in quantum information theory and pioneers in the application of statistical-inference methods to it. Hence he is in the best position to carry out the project and become an established researcher, who will be acknowledged for his inter-disciplinary expertise and his contribution to an outstanding technological problem. The scientific part of the project is complemented with a well-balanced training program: advanced training-through-research, participation to a machine-learning school, transferable-skills for career development. The researcher will engage in teaching to undergraduate students, the organization of seminars and of a machine-learning reading club. Potential exploitation of the results will take place at a quantum industry da
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Wireless, Scalable and Implantable Optogenetics for Neurological Disorders Cure'.

assistant: **Innovation**

This WiseCure Fellowship aims to bring novel wireless, scalable, MRI-compatible, and bio-integrated neural implants for optogenetics to treat epilepsy. Neurological diseases such as epilepsy is a life-threatening progressive disorder causing uncontrolled activity of the brain (seizure). The ability to decipher brain functions and understand the neuronal communication networking properties to develop innovative solutions to treat neurological diseases remains one of the biggest challenges to date. A recent approach to study the brain is optogenetics. Optogenetics is a neural modulation technique which utilizes light to stimulate genetically engineered neurons, providing a better option for controlling the cells compared to conventional electrical stimulation.  Scientists pursuing optogenetic therapies still face some technical challenges (e.g. size and multifunctional capability, biointegration, wireless capability, Magnetic Resonance Imaging (MRI) compatibility) that keeping optogenetics from clinical trials for brain diseases. I will combine the innovative wireless power transfer (WPT) approaches with ultrathin, soft and flexible biocompatible polymeric platforms to fabricate and characterize neural implants that are small enough to promote scalability, chronic reliability, and MRI compatibility. By associating the ability to wirelessly monitor (e.g. neural activities) and control (stimulation or inhibition) through these neural implants using a smartphone establishes a novel approach for versatile optogenetics to treat epilepsy.  This Fellowship will act as a platform to realize my futuristic vision by integrating the wireless optogenetics system into smart healthcare using mobile and electronic technology for better diagnosis of the brain diseases, improved treatment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'NorFA conference women in academia - a nordic perspective' under Fifth Framework.

assistant: **Concept**

The proposed conference is a high-level multidisciplinary scientific event focused on positive action measures for increasing equality in all scientific fields of study in Academia. It aims at providing a critical and balanced appraisal of gender in higher scientific positions. The lack of female participation is still severely impended by a number of social factors, which perpeptuate inequality in terms of women's access to higher positions and leading roles at the universities. A main target of this NorFA conference is therefore to deepen - through studies in equality - the understanding of the factors that hinder women's full participation in science and to explore possible strategies to facilitate women's access to socio-economic decision-making processes and consequently to citizenship in this area. The conference first looks at current knowledge on the topic and then progresses to future scenarios and solution oriented approaches and small wins""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Geometry of exceptional Lie algebras à la Tits' under Seventh Framework.

assistant: **Concept**

The proposal concerns algebraic groups and their associated geometries, in particular those of exceptional type. The main goal of the proposal is to give a uniform axiomatic description of the embeddings in projective space of the varieties occurring in the Freudenthal-Tits magic square.For instance, the second row comprises Severi-Brauer varieties, which have applications in Galois cohomology. Of special interest are the geometries of exceptional Lie type over arbitrary fields, where we would obtain a purely geometric characterization of F4, E6, E7 and E8. In particular this involves a direct construction of the 248-dimensional E8-module.In the spirit of the work of Tits (Abel prize 2008) and Aschbacher (Wolf Prize 2012), there is a nice interaction between geometry and groups. The embeddings (geometry) will provide fruitful information about the subgroup structure of finite simple groups and groups of Lie type over arbitrary fields, and conversely, the expert knowledge of Prof. Liebeck on algebraic groups will help describe the embeddings.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Reconfiguration of Catholic women’s league militancy in France and in Italy (1919-1939)' (1919-1939), addressing dissemination and exploitation.

assistant: **Impact**

This comparative project about catholic women in Italy and in France during the Interwar period (1920-1939) will benefit from the EUI international perspective and structure. Having just completed a comparative study of two important mass organizations of conservative Catholic women in early 20th century France and Italy, namely the Ligue patriotique des Françaises and the Unione fra le donne cattoliche d’Italia, I would like to turn my attention to the vital question of the reconfiguration of French and Italian catholic women’s militancy during the twenties and the thirties. This new project is inspired by a recent discovery made in the archives of Pontifical archives and the Pope Pius XI funds (recently open to scholars) while completing the research for my doctoral thesis. By examining individual political trajectories in the context of collective political stances, this research allowed me to reflect more deeply on processes of politicization at a moment of broader democratization in French and Italian politics (1902-19 in Italy, 1902-33 in France). This post-doctoral project that will continue to follow the political trajectories of different kinds of militants over time, but broadening the scope so as to take into account center and center-left feminists as well as right-wing women in a comparative consideration of the vast re-shuffling of the political deck in the face of fascist and extreme right-wing challenges to democratic politics in the interwar period. Not only would the Marie Curie fellowship afford the time needed for such an ambitious study, it would also allow me to access specific publications held in the Biblioteca Nazionale di Firenze, and to encounter international specialists of European history based in the department of History and Civilization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Nanoscale Effects within Biological Membranes caused by Radiation'.

assistant: **Innovation**

The NanoMembR project will elucidate key elements of membrane stability under the influence of UV radiation. The stability of biological membranes is of great importance for the structure, homeostasis and functioning of all living systems. Membrane molecules have also attracted, due to their robustness and longevity, strong interest from planetary and space scientists as potential biomarkers for life detection missions to other planets. Membrane damage, perturbation, instability and fragmentation upon UV exposure will be investigated on the nanoscale using cutting-edge infrared nanoscopy. Scattering-type scanning near-field microscopy (s-SNOM) combined with Fourier transform infrared (FTIR) spectroscopy allows to combine spatial information of nanometre resolution with chemical mapping. This novel technique will enable us to study subtle changes in the structural integrity of model membranes and monitor changes in the micro- and nano-domains. In addition, we will be able to correlate membrane stability and membrane composition by intercalating structural and functional modifiers such as sterols, hopanoids and pigments. Upon radiation in oxic environments, the lipid structure of a membrane is known to be altered by peroxidation chain reactions. Under anoxic conditions radiation induced changes in lipid alteration could vary significantly, with intriguing implications for the stability of membrane molecules under different environmental conditions than found on Earth. Understanding fragmentation patterns of membranes and identifying final break-down products will provide scientific support and a database for key biomarkers detectable in remote environments. Results from this work will feed directly into planned experiments on the International Space Station (ISS), which a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Economics of Health Care Markets and Innovation'.

assistant: **Concept**

Medical progress over the last century has undoubtedly improved our well-being. However, the equal access to health care and its economic sustainability are challenged by the scientific revolutions of genetics, the nature and extent of new risks and the growing externalities across countries that put at risk the production of health care public goods. The development of new cell and gene technologies holds the potential for creating therapies for conditions like cancers and genetic diseases. However, the associated costs may be prohibitively high. It is crucial to find ways to provide an environment where such innovations are produced in the most efficient and accessible way. Furthermore, the incentives provided by intellectual property protection, which drive innovation, and measures to reduce research and development costs, are vulnerable to international free riding and can be in contradiction with competition policy.The objective of this research program is to conduct policy-relevant analyses that address these challengesand contribute to a better understanding of optimal public policies and regulatory interventions. Several research directions will be pursued focusing on national price regulation. These regulations must consider potential cross-country externalities arising from explicit reference pricing used by regulators, international trade considerations, and the need to collectively finance socially valuable innovations. The exploration of alternative pricing mechanisms, such as indication-based pricing, quantity-based pricing, and exclusivity extension rules, will be undertaken as potential tools to improve efficiency. Moreover, the promotion of pharmaceuticals, both by the private sector and public entities, will be examined. Additionally, the research prog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'What is the mechanism of the true chronic effect of dietary polyphenols?' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Although there have been many epidemiological and intervention studies on polyphenol-rich foods showing promising effects in reducing the risk of heart disease and diabetes, the true mechanisms of action remain elusive. In vitro systems to study nutritional mechanisms are limited by several factors and most have been derived from acute studies relevant to pharmaceutical research. In order to determine the chronic and true mechanisms of effects of dietary polyphenols that occur in the body as a result of diet, a paradigm shift in thinking is needed in the design of in vitro experiments. Based on human bioavailability data, I propose to develop suitable systems for the chronic study of polyphenols, and test these with the metabolites actually formed according to data from in vivo studies. The disparity between in vitro and in vivo studies will be bridged by the development of multi-cell type and engineered cells, overcoming some of the limitations of cell culture experiments. Based on these cells, chronic exposure to the main classes of polyphenols and metabolites, as found in blood, will be conducted using appropriate time scales and measuring relevant biomarkers. The groundbreaking nature will be to discover how polyphenols are actually working in the long term, more equivalent to lifetime exposure to foods. The experimental approach is designed to test the hypothesis that the exposure of cells to chronic low levels of metabolites, relevant to real nutrition, will have significant and different effects to those observed at acute high concentrations. This will finally provide the elusive explanation for the protective effects of polyphenol rich foods in epidemiological studies. The project involves a unique mixture of in vivo and in vitro experiments, the result of which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'CBASS: Life, Death and cyclic nucleotides' (CBASS) targeting Horizon 2020.

assistant: **Abstract**

All living things are subject to attack by viruses. Cells have evolved many different immune systems to protect themselves, including the adaptive and innate immune systems of vertebrates and the CRISPR and restriction:modification systems of bacteria. Viruses have developed potent countermeasures to subvert these systems, and this perpetual arms race has been a strong driving force in evolution throughout the history of life on Earth. CBASS (cyclic-oligonucleotide-based antiphage signalling systems) is a newly discovered bacterial immune system with evolutionary links to the eukaryotic cGAS-STING innate immune pathway. CBASS generates an astonishing array of cyclic di- and tri-nucleotide signalling molecules that in turn activate a diverse range of effector proteins to combat phage infection. These cyclic nucleotide second messengers thus lead to life or death decisions for infected cells.  CBASS are abundant in pathogens and the microbes that dominate the human digestive system: this microbiome and the viruses that infect it are now implicated in diverse aspects of human health. This is a powerful and complex defence system, but fundamental aspects are not understood. How is viral infection detected by bacteria, triggering cyclic nucleotide production? What are the consequences for the cell: does activation inevitably lead to cell death, or is there a mechanism to switch it off? What role does protein modification play? Furthermore, how do viruses overcome CBASS defence? These questions will be addressed using a cutting-edge combination of structural and molecular biology, bioinformatics, biochemistry and microbiology. We propose a ground-breaking study of CBASS defence, with a focus on discovery of new enzymes, pathways and mechanisms. This work will open up new para