RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Role of c-Myc in atherosclerotic macrophages' (MYCMACS) targeting Seventh Framework.

assistant: **Abstract**

Atherosclerosis and associated cardiovascular disease are the leading causes of mortality in developed countries and the World Health Organization has estimated that by 2020 these disorders will be the main sanitary and socio-economic problem world-wide due in part to the progressive aging of our societies. Atherosclerosis is a complex chronic inflammatory process triggered and perpetuated by cardiovascular risk factors which cause endothelial dysfunction and leukocyte infiltration within the subendothelial space in the artery wall. The most prominent immune cells that invade lesions are monocytes/macrophages (comprising up to 60% of atheromata mass) and T-lymphocytes. Recent evidences suggest that different atherosclerotic stages are associated with distinct macrophage subtypes, principally the classically-activated (M1) and alternatively-activated (M2) populations. The main obstacle to the anti-atherosclerotic therapy based on targeting atherosclerotic macrophage is that very little is known about the intracellular pathways and transcription factors involved in macrophage activation. I recently demonstrated that the transcription factor c-Myc is specifically induced in human macrophages during M2 alternative activation and controls the expression of around 50% of M2-specific markers. The main goal of this project is to elucidate the role thatc-Myc plays in macrophage functions that are relevant in atherosclerosis (eg., proliferation, apoptosis, migration, lipid uptake) and the effects of ablating macrophage c-Myc expression on disease initiation and progression.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'APPLICATION IN A WECS OF A DOUBLY FED GENERATOR WITH ROTOR FREQUENCY CONTROL' in the context of a Fourth Framework call.

assistant: **Objectives**

The aim is to introduce an innovative conversion system for variable speed operation in a wind class III 48 diameter horizontal axis turbine with 600 kW installed power. The present conversion system is based on a 100% inversion of the produced power, that is recognized to produce an optimised power curve and excellent power quality. These aspects and the load spectrum remain the same, but the cost of the system can be reduced with 35%. The aim is to verify these specifications by means of a measurement programme and to verify the target of 35% cost reduction on the conversion system (generator, inverter and cabling). The aim is to release, after verification, the proven design for series manufacturing and to give the WindMaster product range a better market position. It is expected to install 100 turbines a year, what, regarding present interest in the turbines, is a conservative assumption.The main effort in the project is the installation of a WM 600 VS 48 with doubly fed asynchronous generator with rotor frequency control.The objective is to demonstrate the proper functioning of the above mentioned conversion system. The specifications regarding power curve, noise level, power quality and load spectrum for the same turbine equipped with asynchronous generator coupled to a full size inverter system will have to be met. The objective is to reduce the cost of the generator - inverter system with 35%. Technical aspects :The turbine is specified in published documentation. Due to the modular design the generator can be replaced by the double fed generator with minor chargings only. DESIGN : To implement the conversion system following design work has to be done. For the conversion system the basis is a working 100 kW prototype system. This system will be engineerd toward
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Chemical genomics by activity monitoring of proteases' (CAMP).

assistant: **Innovation**

Proteases are key molecules in biological systems. They modify numerous proteins by hydrolytic cleavage, thus controlling and executing many physiological processes. Their intricate networks require a tight regulation to prevent fortuitous proteolysis. Where this regulation fails, proteases trigger pathologies such as neurodegeneration, inflammation, and cancer. Many therapeutic approaches are directed towards proteases or their natural inhibitors, already leading to drugs against life threatening diseases.The tight regulation of proteases by posttranslational modifications makes current functional genomics technologies unsuitable to fully establish biological relevance. CAMP will lay the groundwork to study and understand proteases through activity labeling and functional imaging in cells. Specifically, we will investigate the substrate specificity of proteases using large peptide libraries, derive fluorescent labeling molecules from the sequence information gathered, and use these molecules to investigate proteolytic activities in cellular environments. A set of 45 proteases covering four prototypic protease subfamilies has been selected taking into account scientific relevance, structural diversity, and potential socio-economic interest.Given the estimated number of 600 to 1100 proteases in the human genome, our selected set constitutes a significant representation and will establish the feasibility of our approach to address the protease proteome. CAMP's proteases will serve as prototypes to develop novel protease-specific technologies and probes for studying expression and folding, the activity state of proteases and their endogenous interaction partners in vitro and in vivo. The gathered information will be annotated in a public repository. We expect that the deri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A functional proteomics approach to extracellular redox signalling' to be submitted under Sixth Framework.

assistant: **Abstract**

Biological redox reactions have been identified as control mechanisms for all aspects of cellular life. Extracellular redox signals contribute to cellular communication, including host-tumour and host-pathogen interactions.Recent evidence suggests that disulfide bonds in extracellular domains of cell surface receptors have the potential to act as redox-operated switches for protein function. However, target proteins of extracellular redox activity are mostly unknown and the impact of specific cell surface redox changes on cellular interactions and signal transduction remains to be studied.We propose to identify and functionally analyze redox-regulated surface proteins involved in cellular communication. We will focus on redox signals involved in the activation of primary T cells and in the growth of transformed T cells. Both processes are stimulated by the thiol-disulfide oxidoreductase thioredoxin-1, which is either secreted by dendritic cells in response to antigen-specific recognition of T cells or by T cells themselves as a result of transformation.The extracellular activities of thioredoxin are known to depend on its redox activity. It is not yet understood how redox changes on the cell surface effect increased sensitivity to particular growth factors and cytokines. In order to identify thioredoxin-regulated proteins on T cells we will apply novel strategies of functional proteomics, including mechanism-based trapping with mutant thioredoxin-1.Thioredoxin-based signals and their disruption will be analyzed in a DC-T cell coculture system. We are also pioneering techniques to track redox changes by flow cytometry and thereby aim at correlating in vivo events with specific redox signals. We expect to obtain fundamental insight into the emerging field of extracellular
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Smart monitoring in train systems' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This proposal aims at new needs for diagnostics on trains and electrical infrastructure due to the deregulation and interoperability of the EU track. The contact between overhead contact line OCL and current collector/pantograph is an interface between new established track & train operators. Permanently monitoring the thermal & mechanical stress load caused by a train running under the OCL allows to predict the resulting wear. This allows enhanced cost transparency for the operators, makes predictive maintenance possible and allows more efficient, faster and safer use of existing stock. The interoperability in a very heterogeneous EU electrical infra structural net will be increased. For high-speed trains, load monitoring is becoming essential, as non-optimised contact forces produce excessive wear and cause environmental noise. The EU is addressing these goals with a planned upgrade of existing rail network, Trans-European Net.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Video Imaging Demonstrator for Earth Observation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The project aims to develop a highly-disruptive Technology for an instrument offering Video Observation of Earth: an novel architecture will be demonstrated, based on state of the art technologies for mirrors (freeform), structures (additive manufacturing) & detection (new generation detector & processing chain). It will allow to answer  new types of problematics and missions, anticipating the emergence of on-board smart algorithms. The VIDEO project will be a new type of instrument designed to be used with the next generation of on board processing capacity. Due to its specific & innovative technologies and architecture, the VIDEO instrument will be the pathfinder of the next instrument generation for Earth Observation.The VIDEO project proposes a set of breakthrough technologies for Earth Observation instruments, including freeform mirrors, structure in AlSix (low deformation) Additive Manufacturing (with increased demise capacity), as well as a new detection channel with video acquisition. Indeed, the VIDEO project is the future of the small & compact instrument with extra wide field of view. Based on TAS’ exclusive patent combining in a smart optical compact design, the VIDEO instrument will have the capability to perform High Resolution video monitoring on an extremely wide scene. The VIDEO project includes a downscaled instrument that will demonstrate on the ground the functional viability of all these technologies mixed together with an end to end demonstration.All the partners, which are from the European space industry value chain, will be involved in both  the development and the demonstrator manufacturing of the VIDEO solution: TASF is the coordinator, designed of the global solution and end-user; Poly-Shape is the additive manufacturing partner; AMOS is the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Combinatorial methods in noncommutative ring theory.'.

assistant: **Concept**

As noted by T Y Lam in his book, A first course in noncommutative rings, noncommutative ring theory is a fertile meeting ground for group theory (group rings), representation theory (modules), functional analysis (operator algebras), Lie theory (enveloping algebras), algebraic geometry (finitely generated algebras, differential operators), noncommutative algebraic geometry (graded domains), arithmetic (orders, Brauer groups), universal algebra (co-homology of rings, projective modules) and quantum physics (quantum matrices). As such, noncommutative ring theory is an area which has the potential to produce developments in many areas and in an efficient manner. The main aim of the project is to develop methods which could be applicable not only in ring theory but also in other areas, and then apply them to solve several important open questions in mathematics. The Principal Investigator, along with two PhD students and two post doctorates, propose to: study basic open questions on infinite dimensional associative noncommutative algebras; pool their expertise so as to tackle problems from a number of related areas of mathematics using noncommutative ring theory, and develop new approaches to existing problems that will benefit future researchers. A part of our methodology would be to first improve (in some cases) Bergman's Diamond Lemma, and then apply it to several open problems. The Diamond Lemma gives bases for the algebras defined by given sets of relations. In general, it is very difficult to determine if the algebra given by a concrete set of relations is non-trivial or infinite dimensional.  Our approach is to introduce smaller rings, which we will call platinum rings. The next step would then be to apply the Diamond Lemma to the platinum ring instead of the origina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'EVEARA: Testing a New Business Model for Digital Music Distribution' in the context of a Horizon 2020 call.

assistant: **Objectives**

For the first time, digital music surpassed physical music sales in the first quarter of 2016. This booming industry is growing quickest in Europe, at 14% annually. Europeans want to download and stream music, especially European music. More and more demand side services (Apple, Deezer, Spotify, etc.) are popping up as a result – now more than a billion tunes are streamed/downloaded from 500+ services. Each service has its own specific, extensive, and often complicated requirements for how music is ingested into it, however, eliminating over 90% as viable outlets for artists and rights holders (SMEs) trying to make a living from their music.EVEARA is the missing link for those SMEs to access all relevant digital distribution channels and reach markets and listeners exponentially, increasing their revenues and creating new white label businesses throughout Europe. By serving multi-channels (artists, SME producers/labels and other copyright holders, and large enterprises), EVEARA is not only simplifying digital distribution to a degree that has never been done before, but it is also creating a revolutionary business model that will take 1.6% of the market share. EVEARA empowers SMEs to distribute in one step. No other service in the world offers the ease and benefits of EVEARA, designed particularly for Europeans by European music professionals, nor approaches the problem from a top down business model. B2B partnerships with music distributors, telecoms, etc. are providing a base of immediate revenues and hundreds of thousands of artists and rights holders.  This study will help us serve those European clients better by testing a launch strategy to them in September and redesigning software and sales elements accordingly based on their feedback. The sales strategy will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quantum simulation of far-from-equilibrium gauge theories' (QuSiGauge).

assistant: **Concept**

Gauge theories (GT) are the staple of the Standard Model, and their far-from-equilibrium dynamics opens a window into the most fundamental questions of high-energy physics (HEP) and the nature of equilibration in isolated quantum many-body systems. However, this dynamics is often highly nonperturbative and difficult to probe using classical methods due to entanglement buildup. Through quantum advantage and tunability, quantum simulators (QS) emerge as a particularly suitable venue to solve this problem.QuSiGauge hinges on developing an overarching framework composed of two main interconnected pillars: a technological one focused on designing robust tunable experimentally feasible QS of GT, and a phenomenological one concerned with a rigorous formulation of far-from-equilibrium quantum criticality and equilibration in isolated many-body models. The project will focus on the quantum simulation of (non-)Abelian GT, qudit quantum computing for HEP, non-ergodic dynamics of GT, and extracting far-from-equilibrium quantum critical exponents from dynamical phase transitions in GT. The approach is organized such that it provides both basic intuition and formal understanding, while emphasizing quantitative predictions accessible to state-of-the-art and near-term QS.QuSiGauge will pave at least two solid paths to uncover new physics: (1) It will provide a toolbox for probing engineered exotic GT and gauge-noninvariant dynamics not easily accessible to particle colliders, yielding tunable platforms for investigating the equilibration of controlled isolated many-body models. (2) It will advance QS towards the holy grail of making them a reliable complementary venue for exploring collider-relevant physics. QuSiGauge will be of immediate impact to current cold-atom and ion-trap experi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'HAZARDOUS GOODS INFORMATION SYSTEM' (HAGIS) targeting Fourth Framework.

assistant: **Abstract**

HAGIS is developing an information service to improve security in the handling and transport of dangerous goods. At present, safe operations may be compromised by regulations in several languages for different forms of transport to meet differing national requirements. The project aims to demonstrate the feasibility of a user-friendly telematics-based information service on regulations governing this activity, irrespective of EU language and the means of transport adopted. The pilot application will be built on top of a commercial document retrieval system, with support for multilingual operation and automatic terminology extraction.Progress on the Project A Market and User Requirements Survey was conducted in four pilot countries: France; Germany; Greece; and Spain. This confirmed the basic assumptions of the need for simplified access to multi-lingual regulatory information about Hazardous Goods. Serious interest has been expressed by industrial companies as well as the freight forwarding, maritime and road haulage industries. The language engineering content and techniques used to produce the HAGIS information base has attracted the interest of members of international organisations involved in the restructuring and harmonisation processes of the different codes and recommendations. For them HAGIS could prove a very useful tool. The detailed requirements resulting from the survey have formed the basis for the specifications of the pilot service. Full design specifications and a preliminary demonstrator were complete at end 1996. Market and User Requirements Survey All types of potential users were contacted in the course of the survey in each of the four countries. The overall response was very positive. Some countries and some of the larger chemical firms and ports