RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Inference for a Semi-Markov Process using Hazards Speciﬁcation' (ISMPH), addressing dissemination and exploitation.

assistant: **Impact**

Let A=(a0,a1,...,ak) denote a ﬁnite collection of ordered transient states traversed by an individual on study for a specific period of time. In medical studies, the initial state a0 often corresponds to an initial disease-free state, while states ar (r =1, 2,…,k) would represent repeated non-fatal events of the same type (see, MacKenzie (1997), “On a non-proportional hazards regression model for repeated medical random counts”, Statistics in Medicine, 16, 1831-1843).Associated with the states ar (r =1, 2, …,k) are the times Tr (random variables) at which transitions occur from states ar−1 to ar so that the underlying stochastic process may be described by (a0,T1,a1,T2,…), overall. Let the hazard for the r-th event be modeled byλr(tr|xr)= λ0(tr)h(tr,xr),where λ0(tr) is some baseline hazard function, xr is a vector of covariates measured at baseline and at each subsequent event (r≥1), and h(tr, xr) is some link function associating the covariates to the hazard function, which itself may be assumed to involve tr or not.There are two approaches one could take in order to estimate the above model: either to take the baseline hazard function in a speciﬁc parametric form (for example, to be Weibull, lognormal, etc.) or to take it in a nonparametric form (for example, as a stepwise constant form, etc.) and develop the corresponding statistical analysis based on maximum likelihood estimation. Additionally, there are many choices of the link function that one could make, such as a log-linear link function (like in a Cox’s proportional hazards model). General point estimation, interval estimations and tests of hypotheses based on the likelihood criterion will be of interest to develop and this will be the primary aim of the project. In addition, validity methods of the use of suc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The Globalisation of Ice Sheets: a Scientific and Political History'.

assistant: **Innovation**

The proposed project 'The Globalisation of Ice Sheets: a Scientific and Political History' (ICEglobe) charts and questions the historical processes of knowledge production and utilization that have transformed the Greenland and Antarctic ice sheets from geographical unknowns into objects of global significance within the context of climate change. Forecasting the future of ice sheets, their contribution to sea level rise and its global consequences has become a top priority for governments and international bodies such as the IPCC. Despite the increased resources allocated to the physical study of ice sheets, however, very little attention has been given to their scientific and political history. ICEglobe argues that if our societal and governmental response to ice sheet melt is to be fully informed and effective, there is an urgent need for more nuanced analysis of how ice sheet knowledge has been produced and utilized in the past. Drawing on the archives of the Scott Polar Research Institute in the University of Cambridge (the host), of my secondment partner organisation, and of other repositories in Europe and internationally, the project will research the intertwined processes of scientific and cultural exchange between the Greenland and Antarctic ice sheets. It will examine the collaborative, technological and geopolitical contexts that have shaped ice sheet knowledge over the same period; it will question how ice sheet modelization and melt have sparked the re-emergence of debates around catastrophism and irreversibility; and it will consider how ice sheets challenge the idea and logic of human-nature reciprocity and coexistence. ICEglobe will be supervised by a Cultural, Political and Historical Geographer specialized in the Polar Regions and will be enriched by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Macromolecular crowding in membranes' in the context of a Sixth Framework call.

assistant: **Objectives**

The aim of the project is to understand, quantify and model the influence of protein crowding in membranes on molecular mobility and interactions of membrane proteins and ultimately on cellular processes in particular signalling. In cellular membranes proteins occupy almost half of the available surface.Obviously, this high total concentration of macromolecules within the membrane will influence processes in the membrane, even while the concentration of proteins involved in a particular process itself is low. Phenomenological data from animal models showed that signalling kinetics and sensitivity in the visual process, thus likely in G-protein coupled receptor (GPCR) signalling in general is strongly depending on the membrane-protein concentration.However, t he influence of macromolecular crowding on interaction kinetics and equilibria has not been studied experimentally in membranes so far. An in vitro system will be established, in order to monitor how protein-protein interactions in membranes are effected by increasing concentrations of proteins in the membrane. As a read out, state of the art single-molecule fluorescence techniques will be used.Finally, the findings will be related to data obtained in living cells, establishing the relevance of macromolecular crowding in membranes for biological systems and GPCRs specifically.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Improving stress memory and salt tolerance in barley' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The improvement of crop salt tolerance is a pressing agricultural challenge because salt stress poses a major threat to global food supply. The problem is topical in India where salinity-induced yield losses are increasing for several crops. Compelling evidence indicates that repeated stresses provide a memory to increase tolerance, but the mechanisms are not well understood. This project studies the role of jasmonates (JAs) in priming salt stress memory in barley, one of the most important cereals worldwide for food, malt and animal feed. The main objective is to determine how JAs prime plant salt stress tolerance to overcome the limits imposed on growth and yield. The study will enable the effective use of genetics and genomics to improve salt tolerance by 1) determining the correlation between transcriptome and translatome during growth (inhibition) associated with stress adaptation; 2) characterization of the dependency of the responses from epigenetic changes and the uncharacterized barley JAs receptor COI1, and from the ribosome inactivating protein JIP60. The research will characterize, (A) JAs-primed salt stress adaptation; (B) the mechanisms balancing stress adaptation and growth.To achieve the aims, controlled JAs/salt stress will be applied to monitor organ growth. Growth and cell cycle analyses, alongside RNA-Seq, genome-wide analysis of mRNA translation during development and analysis of specific histone markers will be performed. This will demonstrate how poised gene expression and translation work together to set up stress memory. Plant response to salinity and its impact on yield and metabolism will also be analyzed. This multidisciplinary project will enhance the researcher career prospects when returning to India to establish their own lab continuing w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Rebuilding an Inclusive, Value-based Europe of Solidarity and Trust through Social Investments' (RE-InVEST).

assistant: **Innovation**

In 2013, as a response to rising inequalities, poverty and distrust in the EU, the Commission launched a major endeavour to rebalance economic and social policies with the Social Investment Package (SIP). RE-InVEST aims to strengthen the philosophical, institutional and empirical underpinnings of the SIP, based on social investment in human rights and capabilities. Our consortium is embedded in the ‘Alliances to Fight Poverty’. We will actively involve European citizens severely affected by the crisis in the co-construction of a more powerful and effective social investment agenda with policy recommendations. This translates into the following specific objectives:1. Development of innovative methodological tools for participative research, involving mixed teams of researchers, NGO workers and people from vulnerable groups in the co-construction of knowledge on social policy issues;2. Diagnosis of the social damage of the crisis in terms of (erosion of) human rights, social (dis)investment, loss of (collective) capabilities;3. Analysis of the relationships between the rise of poverty and social exclusion, the decline of social cohesion and trust, and the threats to democracy and solidarity in the EU;4. Development of a theoretical model of social investment, with a focus on the promotion of human rights and capabilities;5. Application of this model to active labour market policies and social protection: evaluation of policy innovations through qualitative and quantitative analyses;6. Application of the same model to public intervention in five selected basic service markets: water provision, housing, early childhood education, health care and financial services, through qualitative and quantitative analyses;7. Analysis of the macro-level boundary conditions for successfu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Ostreid herpesvirus 1: Genetic selection of Resistant strains and environmental interaction in the Atlantic coast of Spain (Galicia)'.

assistant: **Objectives**

One of the main concerns in the aquaculture sector is the significant mortality of the Pacific oyster, Crassostrea gigas, the principal shellfish cultivated worldwide. Among other factors, the presence of a virus has been directly associated with these mortality events which can largely exceed normal losses. The economic impact of the disease in oyster production has reached worrying levels since it has been spread to important producer countries in both hemispheres. Bivalve disease control can be a challenge due to the lack of an acquired immune response and therefore the impossibility to treat them. Long term solutions such as selection of resistant strains have been referred to as a priority by the scientific community. Novel sequencing methodologies have increased the genetic information on this specie and the development of selective breeding programs is nowadays more achievable than ever before. In this study, resistant strains will be genetically characterized and investigated in the field in order to identify the molecular markers required for assisted selection in future breeding programs. The relationship between environmental parameters, virus transmission and virus prevalence will be further studied with the aim of describing an early detection method of oyster mortality.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CO2 reduction through automotive biocomponent enabling and sustainable step changes in fuels and lubricants performance' (2002-2006).

assistant: **Concept**

EU environmental policies on local air quality, climate change and sustainability are continually bringing changes to fuel and lubricant products via Fuel Directives. This proposed industry-academia interchange addresses key step changes necessary to reali se EU targets by enabling the use of bio-components and by improving combustion and lubrication efficiency. The optimization of fuel composition (including effective biofuel introduction) is critical for automotive engine and catalyst technologies for the period 2010-2020. Understanding lubricant oxidation behaviour is key to improving engine and machine efficiency. The modeling of oxidation kinetics, the thread that underpins this proposal, is the common scientific fundamental for fuel and lubricant scien ce. Long-term collaborative relationships will be established between Shell Global Solutions, the coordinating host organisation (at their two research sites in Chester and Hamburg) and eight partner universities (Dublin, Eindhoven, Heidelberg, Istanbul, L ulea, Napoli, Stockholm and Thessaloniki). This will link their collective combustion and lubrication scientific knowledge directly with Shell GS' longstanding R and D capability in fuel and lubricant formulation. In the first two years, experienced univer sity researchers will participate in multi-disciplinary R and D projectscarried out at Shell GS. An annual one-week workshop will bring together all the participants (researchers, industrial and university supervisors, and an advisory board), enabling new technical synergies to be established. Industry approaches to the commercialization of knowledge will be conveyed to each university via an annual two-week visit by a senior Shell researcher. To demonstrate commitment to a durable collaboration, Shell GS w ill
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Clean Sky Support Action' to be submitted under Seventh Framework.

assistant: **Abstract**

The ""Clean Sky "" Joint Technology Initiative aims at realising a quantum leap in the technological capability of Europe to produce aircraft that satisfy environmental needs and are economically viable. The Joint Technology Initiatives will be outside of the mainstream ""calls for proposals "" means of implementation of the work programme. In order to facilitate the early start-up of the JTI and ensure a rapid transition to full operational readiness the Founding Members of the ""Clean Sky "" JTI are applying to the European Commission to benefit from a Coordination and Support Action (CSA). The purpose of this Action is to develop the overall scheme for the implementation of the project. This scheme includes technical, governance, operational, communication and management issues that must be clarified and defined in detail to lay down the basis for future operational readiness. Technical content will be examined and developed to provide an in-depth Work Breakdown Structure with detailed responsibilities and to identify any gaps and overlaps. The Governance Structure of the JU, the legal entity responsible for ""Clean Sky "" activities, will be drawn up in collaboration with the EC lawyer. A scheme with timescales and procedures will be laid down for the implementation of the Call for proposals and Call for tenders. Both internal and external communication processes will be elaborated. The external communication strategy is important for full visibility of Clean Sky activities. This will include developing a Web site, a communication pack, a newsletter, a leaflet and organising a mobilising event about Clean Sky for end 2007. Finally, management team structure will be planned including a description of individual profiles for the future staff.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ennovation-NET: preparing an innovation through e-economy" INNO-NET"' (ENNOVATION) targeting Sixth Framework.

assistant: **Abstract**

ennovation-NET will enable future coordination among the national e-business and innovation programmes of several countries, with a view to increase their national and European impact and to implement joint programmes. For this purpose we plan to carry out a set of support activities in the spirit of the European Innovation Area (EIA) and especially in view of the enlarged EU in order to lay the ground for a Coordinated Actions project to be proposed in FP7. ennovation-NET is reflecting on - and preparing to address in a future CA project - how to achieve coordination between national ebusiness and innovation policy Programmes, how to design trans-national e-business Programmes seeking to improve the innovative behavior of SMEs, how to avoid compartmental approaches in diffusing and applying e-business technologies and practices, how to develop a system of networked national innovation/e-business policies in Europe and finally how to create an e-business/innovation policy platform that brings together innovation and e-business stakeholders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'MICROBIOME-DRIVERS OF LIVER FIBROSIS' (MICFIB) targeting Horizon Europe.

assistant: **Abstract**

Liver fibrosis is increasing in prevalence in many Western populations (mainly due to alcoholic liver disease and non-alcoholic fatty liver disease) and has a major burden on care provision as to date there is no specific intervention to reverse fibrosis. One of the factors that could regulate liver fibrosis is the intestinal microbiome, as various microbial derived compounds reach the liver through the portal vein and act on the liver cells including stellate and Kupffer cells, the main drivers of liver fibrosis. My hypothesis is that the hepatic stellate cells phenotype could be driven by the microbiome and microbial derived metabolites. The key objective is to gain comprehensive understanding on how the microbiome modifies liver homoeostasis and contribute to liver fibrosis development using analysis of the network perturbation in disease, coupled with microbiome experimental techniques. To achieve this, I plan to answer three main questions: 1) which microbiome states and microbiome derived metabolite modulate fibrosis; 2) how does these microbiome states and metabolites changes the hepatic stellate cells phenotype at a cellular and spatial level; 3) which are the mechanisms by which the microbiome modulates liver fibrosis. This will allow characterizing in depth and dissecting the molecular mechanisms of fibrosis and the contribution of microbiome and microbial associated products.  Furthermore, identification of potential factors affecting the course of the disease may lead to potential assisting therapies involving the microbiome and at term leading to an improvement in the prognostic and management of patients with liver fibrosis.The Marie Skłodowska-Curie Fellowship is an important point in my career because it will allow me to ask relevant and innovative quest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Gravity, Black Holes and Strongly Coupled Quantum Matter' under Seventh Framework.

assistant: **Concept**

States of matter in which the interactions between the microscopic constituents are both strong and quantum mechanical lie at the frontier of our understanding of nature. Such states appear in a wide variety of settings including high temperature superconductors, gases of cold atoms and the quark- gluon plasma created in the high-energy collisions of nuclei. Understanding the properties of such strongly coupled quantum matter poses huge conceptual challenges because standard perturbative techniques break down at strong coupling. In a remarkable development, the mathematical framework of string theory has provided a fundamentally new way to study strongly coupled quantum field theories using a dual, weakly coupled gravitational description. Furthermore, this duality states that the phase structure of the quantum field at finite temperature is precisely described by black hole geometries. The principal thrust of the proposal is to develop our understanding of these gravitational techniques in order to make contact with real world systems, particularly in condensed matter physics.The proposal focuses on four main topics in this emerging, rapidly developing and interdisciplinary field. The first is to extend our understanding of known strongly coupled quantum critical ground states using gravitational solutions and also to search for new ones. The second is to map out the phase structure of strongly coupled quantum field theories at finite temperature by constructing a wide variety of new black hole solutions. Superconducting and spatially modulated phases will be a particular focus. Thirdly, fermion spectral functions will be calculated to extend our understanding of non-Fermi liquids, which are known to arise in many materials. The fourth topic is to explore the behaviour