RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Computational network-based models of tau progression in Alzheimer’s disease', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The aging of the human population has catapulted Alzheimer's disease (AD) from a growing global challenge to an urgent socioeconomic concern. The hallmark of AD is the misfolding and aggregation of proteins β-amyloid (Aβ) and tau in the brain, which can be imaged in living humans using positron emission tomography (PET). Recent clinical trials targeting Aβ have shown promising but modest clinical effects, leading to a shift in focus towards tau due to its closer association with neurodegeneration and cognitive decline. However, tau accumulation is spatially and temporally complex and varies across individuals, complicating its study and therapeutic monitoring. This proposal addresses the need for agile research to enhance our biological understanding of AD while building tools that can aid clinical trials and patient management. I aim to construct TAU-TIME, a computational biology model of tau progression that integrates mechanistic knowledge and individualized data. TAU-TIME will simulate tau accumulation at the individual level and will facilitate testing of biological hypotheses in the context of human AD, where experimental manipulation is challenging. It will also serve as a predictive tool for patient-tailored monitoring, symptom prediction, and enhancing clinical trial power. The proposal encompasses three objectives: 1) optimizing TAU-TIME through integration of spatially-resolved mesoscale human molecular data, 2) leverage individual biological variation at baseline toward patient-tailored models, and 3) benchmark TAU-TIME models on longitudinal tau-PET and cognitive data in a clinical context. These objectives will be achieved through exclusive access to existing data from 2000 patients with extensive neuroimaging and cognitive data, cerebrospinal proteomics,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Prague asterix laser system training site'.

assistant: **Innovation**

The Joint Research Centre PALS provides short stays (3-10 months) training opportunities for PhD students from EC and EC-associated countries. The M.-C. fellows will be trained in basic research of high-power lasers and their applications in laser plasma physics. PALS is organized as a user type laboratory around a high power iodine laser facility (1kJ, 400ps, 1315nm) fully equipped with basic diagnostics and powerful computing infrastructure. The Centre operates also a high power chemical oxygen iodine laser COIL. The research agenda, including both the experiment, computer modeling and analytical theory, covers the following topics:- Physics of hot high density plasma, sources of intense x-ray radiation and of highly charged ions generated at the laser focal spot. Laser plasma diagnostics.- X-ray lasers, and their physical, technological and interdisciplinary applications.- Adaptive optics programme and feasibility studies of optical parametric chirped pulse amplification by the iodine laser beam aiming at generation of high power pulses in the femtosecond region.- Supersonic chemical oxygen iodine laser for technological applications. The fellows will benefit both from contacts with the experienced permanent staff and with the PALS external users. The training will take place at the academic campus, where all the experimental facilities, including the high power laser, are located. The dormitories as well as the co-operating labs of both the Charles University and the Czech Technical University are in the walking distance (10-15 min). The fellows will also take part in regular seminars, lectures and workshops, organized by the Centre and the Universities with common accreditation for PhD training. Eligible for the fellowship are the graduate students in physics, elec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Parallel Distributed Infrastructure for Minimization of Energy'.

assistant: **Innovation**

The increasing power and energy consumption of modern computing devices is perhaps the largest threat to technology minimization and associated gains in performance and productivity. On the one hand, we expect technology scaling to face the problem of dark silicon" (only segments of a chip can function concurrently due to power restrictions) in the near future and lead us to use devices with completely new characteristics. On the other hand, as core counts increase, the shared memory model based on cache coherence will severely limit scalability and increase energy consumption. Therefore, to overcome these problems, we need new computing paradigms that are radically more energy efficient.The objective of ParaDIME is to attack the power-wall problem by radical software-hardware techniques that are driven by future circuit and device characteristics on one side, and by a programming model based on message passing on the other side. In particular ParaDIME willutilize: circuit and architecture operation below safe voltage limits for drastic energy savings, the use of specialized energy-aware computing accelerators, energy-aware runtime, approximate computing and power-aware message passing. The outcome of the project will be a processor architecture for a heterogeneous distributed system that utilizes future device characteristics for dramatic energy savings.Wherever possible, ParaDIME will adopt multidisciplinary techniques, such as hardware support for message passing, runtime energy optimization utilizing new hardware energy performance counters, use of accelerators for error recovery from sub-safe voltage operation, and approximate computing through annotated code.Furthermore, we will establish and investigate the theoretical limits of energy savings at the device, circ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Multivessel versus culprit lesion only percutaneous revascularization in patients with acute myocardial infarction complicated by cardiogenic shock'.

assistant: **Objectives**

Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) represents a major European health care concern with mortality rates between 40-70%. Approximately 70-80% of these patients present with multivessel disease defined as coronary lesions in more than one vessel. The clinician is faced with the decision to either 1) intervene only on the culprit lesion acutely responsible for the initiation of cardiogenic shock, or 2) treat additional lesions considered hemodynamically significant but not acutely triggering the CS cascade as well. Current guidelines recommend percutaneous coronary intervention of all critical lesions. However, due to a lack of randomized trials, these recommendations are solely based on registry data and pathophysiological considerations. Aim of the randomized CULPRIT-SHOCK trial is therefore to compare a) immediate multivessel PCI versus b) culprit lesion only PCI in patients with AMI complicated by CS. A total of 706 CS patients will be randomized in several European countries. The primary endpoint will be 30-day all-cause mortality and/or severe renal failure requiring renal replacement therapy. CULPRIT-SHOCK will therefore determine the optimal percutaneous revascularization strategy in patients with AMI and multivessel disease complicated by CS. In addition, a comprehensive array of efficacy, safety and socio-economic parameters for the chosen population will be assessed. Multiple secondary endpoints and several substudies (microcirculation, biomarkers, angiography) will serve to further understand the presumed differential effects of the 2 treatment arms and to understand the underlying pathophysiology and prognostic markers. From these parameters a multivariable regression model and a risk score for the prediction of clinical prog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'NanoElectroMechanical Systems based on Carbon Nanotube and Graphene' (CARBONNEMS).

assistant: **Innovation**

Carbon nanotubes and graphene form a class of nanoscale objects with exceptional electrical, mechanical and structural properties. I propose to exploit these unique properties to fabricate and study various nanoelectromechanical systems (NEMS) based on graphene and nanotubes. Specifically, I will address two directions with major scientific interests:1- I propose to study electromechanical resonators based on an individual nanotube or on a single layer of graphene. My group has a leading position in this recent research field and the idea is to take advantage of our expertise for two sets of experiments, one on inertial mass sensing and one on the exploration of quantum motion. These two topics are generating at present an intense activity in the NEMS community. Experiments are usually carried out using microfabricated silicon resonators but the ultra low mass of nanotubes and graphene has here an enormous asset. It drastically improves the sensitivity of mass sensing and it dramatically enhances the amplitude of the motion in the quantum regime.2- My team will fabricate and exploit nanomotors based on nanotube and graphene. Only few man-made nanomotors have been demonstrated so far. Reasons are multiple. For instance, the fabrication of nanomotors is technically challenging. In addition, friction forces are often so strong that they hinder motion. Because of their unique properties, nanotubes and graphene represent a material of choice for the development of new nanomotors. We will construct nanomotors with different layouts and address how electrical, thermal or chemical energy can be transformed into mechanical energy in order to drive motion at the nanoscale.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'BERG – Biomedical Epigenomics Research Group' (BERG).

assistant: **Innovation**

Significance: The genetic code of the DNA provides a universal building plan for the cell’s molecular machinery. But a second code is needed to control the complexity of the human body, organizing 100 billion cells with identical genomes into 200 specialized cell types. This second code is called “epigenetic”. Defects in the epigenetic code play an important role in cancer, and they create an opportunity for new therapies. The proposed project is based on the hypothesis that dynamic and non-random changes of the epigenome contribute to cancer progression. I will quantitatively reconstruct the epigenome dynamics observed in leukemia and infer drug combinations that can reprogram the cancer epigenome to a less malignant stage.Innovation & Approach: Technological breakthroughs have created an exciting opportunity for biomedical research: It is now possible to measure the full spectrum of epigenetic regulation operating on top of the genome and to comprehensively characterize the effect of epigenetic interventions. Capitalizing on recent advances, I will pursue an ambitious research agenda on epigenomics in biomedicine that can be summarized by the following formula:  (Cancer Epigenetics + Biomedical Sequencing + Computational Modeling) • X = Biomedical Discovery.The proposed project will cohesively combine basic biology with high-throughput technology and cutting-edge bioinformatics. The multiplying factor X denotes seamless integration – rather than addition – of all three components with equal importance and dedication, giving rise to a systems-level approach to studying epigenomics in biomedicine. The following three specific aims will be pursued:Aim 1. Establish an epigenome research platform addressing biomedical questions (technology development)Aim 2. Dissect the ep
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Projectile exciter for noiseless environment'.

assistant: **Concept**

Noise is not just a nuisance; it affects our health. No accepted financial data exist for the treatment costs of noise-related health problems, but several studies prove its direct relation to stress hormone levels or cardiovascular deceases, and many public organizations promote low-noise environment to protect health and comfort. Noise reduction has become major field of manufacturers’ competition: noise level data appear on domestic machines from mixers to dishwashers, brand names with ‘whisper’ or ‘silence’ are popular, aircrafts are successful due to their low noise levels. The efficient way to reduce noise is the elimination of its source that is usually vibration of some machine elements. Vibration elimination is relevant in the development of electric and self-driving cars where control panels and MEMS devices are sensitive for high-frequency excitations in the same way as high-performance machine tools are with aims at (sub)micron cutting precision.Methods of vibration reduction are based on the so-called modal testing that identifies the machines’ dynamic properties like natural frequencies. The test requires accurate broadband excitation. Commercial exciters have several drawbacks; one of these is the limited applicability for moving targets, rotating shafts. In the ERC Advanced Grant “SIREN”, a patent application was submitted and the pre-prototype of a ball shooter was constructed to excite spindles of machining centres by ball impacts. Experiments with the pre-prototype proved that the contact time is one order of magnitude shorter than that of standard impulse tests, while the force signal is near ideal: prall-free impulses with 30 kHz bandwidth were generated. Potential industrial end-users and distributors expressed interest in case a prototype is devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Southampton oceanography centre: facilities, access and co-operation (SOCFAC)'.

assistant: **Innovation**

Description:Southampton Oceanography Centre: Facilities, Access and Cooperation (SOCFAC) gives access to a spectrum of analytical instruments, located within the Southampton Oceanography Centre (SOC); a purpose-built facility housing the School of Ocean and Earth Science (University of Southampton), four government research divisions (NERC) and the UK, Research Vessel Service. Over 400 academic and research staff plus over 100 doctorate and MSc students work in the building. The facility offers access to a range of mass spectrometry and other equipment.The mass spectrometers include:i) noble gas for tritium, helium;ii) thermal ionisation (TIMS) for Sr, Pb, U & Nd;iii) magnet-sector-based multicollector ICPMS;iv) quad-based ICPMS; (both of the ICP mass spectrometers are coupled to a UV ablation source;v) gas-sourced spectrometer for oxygen and carbon.In addition, SOCFAC offers a suite of radionuclide instrumentation for low-level environmental applications; a Vibrational Spectra Laboratory (laser Raman and FT-IR); an Organic Maturity Laboratory (reflectance and infra-red) and finally an ICP-AES. Sixteen academic and technical staff operate the equipment. The facility will support about 29 visitors per year totalling 230 experimental days.Application:Submit an application through the Facility's website or contact the project manager. Applications are dealt with on a rolling basis with a decision being made within four weeks of the application.Project Manager:Robert W. Nesbitt, School of Ocean and Earth Science, Southampton Oceanography Centre, Empress Dock, European Way, Southampton SO14 3ZH, United KingdomTel: +44-2380-592037Fax: +44-2380-593059E-Mail: rwn2@soc.soton.ac.uk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cyber security cOmpeteNCe fOr Research anD InnovAtion' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Europe needs to step up its efforts and strengthen its very own security capacities to secure its digital society, economy, and democracy. It is time to reconquer Europe’s digital sovereignty. The vision for Europe can only be to join forces across Europe’s research, industry and public sector and to include all talents not just those that have representation in the EU mainstream or are within big organizations. Diversity and inclusion are keys for success. Europe has incredible coverage and talent in the area of IT and cybersecurity. The area of cybersecurity is geographically fragmented across Europe for competences, and often also technically fragmented with problem-specific development of security solutions. There is no doubt that excellent research exists in Europe. Nevertheless, it is a fact that this research does not result in IT products and solutions that contribute to the European Single Digital Market. On contrary, a lot of research, also financed by EU ERC grants, is tested on real data in large US companies that cooperate with them. Europe has to and is already rethinking  this strategy.  CONCORDIA addresses the current fragmentation of security competence by networking diverse competences into a leadership role via a synergistic agglomeration of a pan-European Cybersecurity Center. The vision of CONCORDIA is to build a community a strong cooperation between all stakeholders, understanding that all stakeholders have their KPIs, bridging among them, and fostering the development of IT products and solutions along the whole supply chain. Technologically, it projects a broad and evolvable data-driven and cognitive E2E Security approach for the ever-complex ever-interconnected compositions of emergent data-driven cloud, IoT and edge-assisted ICT ecosystems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'REduction of COgnitive BIAses in Intelligence Analysis' (RECOBIA), addressing dissemination and exploitation.

assistant: **Impact**

The aim of the RECOBIA project is to improve the quality of intelligence analysis by reducing the negative impact of cognitive biases upon intelligence analysis.To this end, we will make an assessment of cognitive biases and assess how these biases affect the practice of intelligence.Building on this initial assessment, best practices to reduce the negative impact of cognitive biases will be defined. Solutions are likely to be found in the following domains:- Software tools- Training of analysts- organization.In order to focus research and development on the needs and requirements of professional analysts, their involvement will be facilitated through the organisation of a series of workshops. During those workshops the end-users will be able to express their needs and requirements. On the other hand, the researchers and developers of the consortium will be able to receive input and guidence in order to identify or develop appropriate solutions. The EUROSINT FORUM,a pan-European not- for-profit association, which is a network with over 400 intelligence professionals working in agencies and administrations across the Member States and EU institutions, will be in charge of this task. End-users include, inter alia, staff from Poland, France, UK, Romania, Lithuania, Hungary, Belgium, Netherlands, and EU institutions such as FRONTEX, EDA, SITCEN, SATCEN, etc. The network has been notified of the RECOBIA project and many end-user organizations have expressed strong interest to participate if the project will receive funding.