RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Toxicity' (TOXICITY).

assistant: **Innovation**

While the objective of modern toxicology is still protection of life against external harmful factors, the focus of research in this field has gradually evolved toward a mechanic oriented science. Also it has become apparent during recent years that food contaminants are a relevant health risk for the consumer. Another novel aspect is the reviewed interest that industry has in the identification of new targets based on mechanistic studies to assess reliably adverse of drugs and to develop new therapeutic principles.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Design of orthogonal molecular probes targeting engineered von-Hippel Lindau (VHL) E3 ubiquitin ligase for the control of intracellular protein levels' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The development of potent, selective and cell-permeable small molecule chemical probes as tools to interrogate and modulate cellular functions of the human proteome is a rapidly growing field. The direct manipulation of protein intracellular level and activity using small molecules has enormous potential to elucidate and validate new drug targets and  therapeutics tools. In the last decade, researchers have discovered an alternative method to directly control the level of protein components inside the cell without altering its DNA or RNA. This approach uses chemicals known as PROteolysis TArgeting Chimeric moleculeS (PROTACS) which exploit the ubiquitin/proteasome pathway to direct the intracellular degradation of any Proteins Of Interest (POI) by linking a section that mimics the recognition? motif of the natural substrate to one that binds the POI. PROTACS enable recruitment of any POI to an E3 Ubiquitin ligase. To date, the strategy has displayed some success, however much improvement is still required to known compounds to make this approach widely useful, and althernative new strategies need to be developed to add to the current arsenal of chemical tools.In preliminary work leading to this proposal the Ciulli Lab. (University of Cambridge) has discovered and characterised the first drug-like small molecules that target the Von Hippel Lindau (VHL) E3 Ubiquitin Ligase and disrupt its interaction with substrate Hypoxia Inducible Factor (HIF) with low micromolar affinities. Harnessing this knowledge, and using these inhibitors as starting points, the proposed research will develop a multidisciplinary approach combining medicinal chemistry, protein engineering with biophysical studies and concerning designed, mutated/engineered VHL-ligand pairs that could ultimately be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Real-time dynamics from quasiclassical quantum simulations of complex systems', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The main goal is to develop, test and apply novel abinitio simulation methods that allow to generate and analyze (in terms of real time based properties) approximate quantum dynamics for complex molecular many-body systems in the rage to 10-100 atoms. Finite systems such as floppy molecules, quantum clusters and condensed matter systems such as water will be covered. The tools chosen are the Car Parrinello method combined with abinitio path integrals. Quantum corrections to the classically autocorrelation function of the dipole operator will be analyzed theoretically first and the assessed numerically based on exact solutions for simple models. In a third step an abinitio path integral molecular dynamics technique will be used to simulate time dependent properties of quantum systems. The system applications will cover floppy molecules as CH5+, C2H3+, HSO2+, H302-. Very interesting is the case of CH5+, where it remains to be seen if the IR spectrum of the C-H stretching band can be computed. Important is the case of quantum corrections to the scattering function, that although some of the approximations are widely used, yet remains unclear the validity and exactness of the approximations. Once the tools and techniques necessary to calculate them are ready, the approximations will be theoretically and numerically applied to real systems such as liquids at low temperatures. The special case of D20 and H2O will be studied.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Planetology Network' to be submitted under Sixth Framework.

assistant: **Abstract**

EuroPlaNet co-ordinates activities in Planetary Sciences in order to achieve a long-term integration of this discipline in Europe. The objectives are to:1) increase the productivity of planetary projects with European investment, with emphasis on major planetary exploration missions;2) initiate a long-term integration of the European planetary science community;3) improve European scientific competitiveness, develop and spread expertise in this research area;4) improve public understanding of planetary environments.These objectives will be achieved by:1) maximizing synergies between different fields contributing to planetary sciences: space observations, earth-based observations, laboratory studies, numerical simulations, data base development;2) co-ordinating the design and development of an Integrated and Distributed Information Service (IDIS) providing access to the full set of data sources produced by these complementary fields. EuroPlaNet integrates most of the European planetary exploration work, with initial focus on the Cassini/Huygens mission to Saturn and Titan, operative between 2004 and 2008. The considerable involvement of the European science community in this mission, the broad diversity of its research objectives and the urgent need to achieve a balanced share of data analysis and its results with American colleagues make Cassini/Huygens an ideal test-bed for the development of activities and tools which will contribute to the optimal exploitation of subsequent planetary missions. In addition to overall co-ordination, 6 further activities will be carried out over a 4-year period: a) discipline working groups b) co-ordinate Earth-based observations to support and complement space missions c) develop an outreach strategy d) exchange of personnel e) EuroPla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Non-Destructive Fully Automated Subsurface Metrology and Inspection for the Semiconductor Industry', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Nearfield Instruments (NFI) is the only European organization offering advanced metrology and inspection (M&I) solutions for the semiconductor industry. In a nutshell, NFI develops machines used by chip manufacturers to check the quality of their products. Without M&I machines, the whole microelectronics industry would not exist, and society would be very different from as we know it today.During the EIC project, we will mature the most advanced M&I machine worldwide, called AUDIRA. AUDIRA will be the first and only technology that can perform non-destructive subsurface metrology and inspection, which means that is able to measure through and below multiple layers of the wafer without damaging it. The need for revolutionary M&I systems, like AUDIRA, is a direct consequence of the evolution of semiconductor devices to smaller geometries and more complex multi-level circuitry. The construction of an advanced wafer fabrication facility to manufacture these devices can cost over €5 billion, which is substantially more than previous- generation facilities. Therefore, chipmakers need to increase the yield to maximize the returns from their manufacturing equipment.Hence, the need for advanced M&I machines, like AUDIRA. AUDIRA is at TRL 5 and will be taken to TRL 8 during the EIC project. NFI is a reputed organization in this industry, with over 160+ FTEs and an experienced management board. The Chairman of the NFI Supervisory Board is Eric Meurice, former CEO of ASML. NFI has a large IP portfolio (71 patents, 29 owned and 42 licensed by TNO, the research institute from which NFI spun off), three locations worldwide, and existing commercial relationships with the most prestigious semiconductor companies, including Samsung, Intel, and TSMC. Our company will break even in 2026, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Breaking Inversion Symmetry in Magnets: Understand via THeory' (BISMUTH).

assistant: **Innovation**

Multiferroics (i.e. materials where ferroelectricity and magnetism coexist) are presently drawing enormous interests, due to their technologically-relevant multifunctional character and to the astoundingly rich playground for fundamental condensed-matter physics they constitute. Here, we put forward several concepts on how to break inversion symmetry and achieve sizable ferroelectricity in collinear magnets; our approach is corroborated via first-principles calculations as tools to quantitatively estimate relevant ferroelectric and magnetic properties as well as to reveal ab-initio the main mechanisms behind the dipolar and magnetic orders. In closer detail, we focus on the interplay between ferroelectricity and electronic degrees of freedom in magnets, i.e. on those cases where spin- or orbital- or charge-ordering can be the driving force for a spontaneous polarization to develop. Antiferromagnetism will be considered as a primary mechanism for lifting inversion symmetry; however, the effects of charge disproportionation and orbital ordering will also be studied by examining a wide class of materials, including ortho-manganites with E-type spin-arrangement, non-E-type antiferromagnets, nickelates, etc. Finally, as an example of materials-design accessible to our ab-initio approach, we use “chemistry” to break inversion symmetry by artificially constructing an oxide superlattice and propose a way to switch, via an electric field, from antiferromagnetism to ferrimagnetism. To our knowledge, the link between electronic degrees of freedom and ferroelectricity in collinear magnets is an almost totally unexplored field by ab-initio methods; indeed, its clear understanding and optimization would lead to a scientific breakthrough in the multiferroics area. Technologically, it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Superfluidity: a super-fluid, cloud-native, converged edge system' under Horizon 2020.

assistant: **Concept**

Superfluidity is “a state in which matter behaves like a fluid with zero viscosity”. Our project aims at achieving superfluidity in the network: the ability to instantiate services on-the-fly, run them anywhere in the network (core, aggregation, edge) and shift them transparently to different locations.The SUPERFLUIDITY project tackles crucial shortcomings in today’s networks: long provisioning times, with wasteful over-provisioning used to meet variable demand; reliance on rigid and cost-ineffective hardware devices; daunting complexity emerging from three forms of heterogeneity: heterogeneous traffic and sources; heterogeneous services and needs; and heterogeneous access technologies, with multi-vendor network components.The SUPERFLUIDITY solution is based on: a decomposition of network components and services into elementary and reusable primitives; a native, converged cloud-based architecture; the virtualization of radio and network processing tasks; platform-independent abstractions, permitting reuse of network functions across heterogeneous hardware platforms, while catering to the vendors’ need for closed platforms/implementations; and high performance software optimizations along with leveraging of hardware accelerators.As a result, the 5G network will benefit from: i) location-independence: network services deployable in heterogeneous networks; ii) time-independence: near instantaneous deployment and migration of services; iii) scale-independence: transparent service scalability; and iv) hardware-independence: development and deployment of services with high performance irrespective of the underlying hardware.Through these properties, SUPERFLUIDITY will provide a converged cloud-based 5G concept that will enable innovative use cases in the mobile edge, empower
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Impact and capacity Assessment Framework for U-space Societal Acceptance' (ImAFUSA), addressing dissemination and exploitation.

assistant: **Impact**

ImAFUSA focuses on quantifying a variety of understudied factors influencing societal acceptance of UAM in urban, peri-urban and inter-urban areas, especially when these are deployed using U3 and U4 services. We aim to deliver an “Impact and capacity Assessment Framework for U-space Societal Acceptance” (ImAFUSA) to assist Local Authorities and other U-space stakeholders and users with the delivery of socially acceptable and beneficial UAM deployment in cities. The framework and its tools will provide insights in 3 major areas influencing societal acceptance: environmental impact (including noise, visual pollution and air quality), safety and socioeconomic impact (including affordability, accessibility, economic development, public space use and connectivity). In each area, innovative performance indicators will be described while mathematical formulas and algorithms will be developed to quantify them. Data on citizen noise perceptions, perceptions on visual pollution, safety perceptions and overall UAM acceptance will be collected during 3 immersive citizen experiences of UAM applications in the city of Athens, Greece. The usability of the developed indicators will be tested in a simulation environment simulating real future use cases with a varying volume and configuration of movements in U-space. Through the collaboration of the Partners and the Advisory Board, ImAFUSA facilitates the flow and co-creation of knowledge and 10 innovative tools between higher education (HEI), innovative SMEs, Local Authorities and National Aviation Authorities. ImAFUSA´s developments benefit a variety of stakeholders including Local Authorities, policy-makers, U-space service providers, ATM/UTM planners and operators, drone manufacturers, environmental agencies and citizens above all.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bottom-up hybrid control and planning synthesis with application to multi-robot multi-human coordination' (BUCOPHSYS).

assistant: **Concept**

Current control applications necessitate the treatment of systems with multiple interconnected components, rather than the traditional single component paradigm that has been studied extensively. The individual subsystems may need to fulfil different and possibly conflicting specifications in a real-time manner.  At the same time, they may need to fulfill coupled constraints that are defined as relations between their states.  Towards this end, the need for methods for decentralized control at the continuous level and planning at the task level becomes apparent.  We aim here towards unification of these two complementary approaches. Existing solutions rely on a top down centralized approach. We instead consider here a decentralized, bottom-up solution to the problem. The approach relies on three layers of interaction. In the first layer, agents aim at coordinating in order to fulfil their coupled constraints with limited communication exchange of their state information and design of appropriate feedback controllers; in the second layer, agents coordinate in order to mutually satisfy their discrete tasks through exchange of the corresponding plans in the form of automata; in the third and most challenging layer, the communication exchange for coordination now includes both continuous state and discrete plan/abstraction information. The results will be demonstrated in a scenario involving multiple (possibly human) users and multiple robots.The unification will yield a completely  decentralized system, in which the bottom up approach to define tasks, the consideration of coupled constraints and their combination towards distributed hybrid control and planning in a coordinated  fashion require for new ways of thinking and approaches to analysis and constitute the proposal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Advanced burner design methodology for efficient and clean gas fired commercial and industrial boilers'.

assistant: **Concept**

Industrial and commercial boilers in use in the EU consume a vast amount of gas, but despite this equipment manufacturers have yet to be provided with adequate engineering design tools for them to develop and operate these boilers free of problems. A major and commonly found problem is the mismatching of burners to boilers, giving rise to interference of the flame with the fire tube enclosure, resulting in losses in operating efficiency, increased of emission levels and occasional damage to the boiler itself. This research aims to produce two burner design tools to improve the burner/boiler design and operation: First, a set of burner design guidelines for practical design work and second, a set of numerical models for detailed precision design. It is expected that these design tools will help to overcome this major industrial problem and transform the burner/boiler industry to become a high technology based industry.These deliverables will be derived from intensive applied research into burner scaling methods and the simulation of industrial turbulent diffusion flames. The work will combine the theoretical development of turbulence and combustion models with detailed in-flame measurements in research burners and in industrial boilers. Parametric studies by mathematical modelling coupled with burner sensitivity tests on the research burners will be used to characterise the highly confined burner flames and their interaction with the enclosures (the fire tubes).This research is in support of the BriteEuram Workprogramme area 2.2 (New technology for production design and manufacture) by developing an easy to use design tool and modelling method as an alternative to the current industry practice which uses expensive and time consuming physical prototyping and a laboratory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Understanding Halophytes for an Agriculture Worth its Salt' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

One of the greatest challenges of the 21st century is to meet the world’s future food security and sustainability needs despite the rapid and large declines in suitable resources needed for the agricultural expansion required in the foreseeable future. As a result, interest in saline resources has escalated over the years but, notwithstanding great efforts from the scientific and breeding community, success in the development of salt tolerant crops remains elusive. For major breakthrough in crop breeding for salt tolerance, there is an urgent need to look at new options to find previously unexplored traits and mechanisms. With a multi-disciplinary approach and state-of-the-art biophysical and molecular techniques used in plant molecular biology, ion transport biology, halophyte ecophysiology and electrophysiology, the project will reveal the fine print of one of the most interesting mechanisms evolved by plants to deal with excess salts and thrive in these otherwise hostile environments. Given that dicotyledonous halophytes use sodium as a cheap osmoticum, the main objective of the project is to unravel the complementary morphological, physiological and anatomical characteristics that enable them to deal with  cytotoxic sodium. The project will focus on four distinct halophytic species (facultative vs. obligate and with vs. without salt bladders): Atriplex nummularia, Chenopodium quinoa, Salicornia dolichostachya and Beta vulgaris ssp. marittima. By understanding how these different halophytes orchestrate efficient vacuolar Na sequestration with greater cytosolic K retention and bladder cell-based desalination, this project is expected to led the way to uncharted pathways to pinpoint key biological mechanisms that could improve tolerance in traditional salt sensitive cr