RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'BARIUM CYCLING IN ANTARCTIC WATERS: UNDERSTANDING PRESENT AND PAST OCEAN PROCESSES' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Ice core records show that atmospheric carbon dioxide (pCO2), an important greenhouse gas that drives and amplifies climate change, varies naturally over a range of timescales.  Biological productivity in the oceans is a major contributor to carbon drawdown, and an important factor controlling atmospheric pCO2.  The Southern Ocean is linked with these climatic events, in part due to upwelling and subduction of deep waters during which carbon and heat are exchanged with the atmosphere, and partly because it exerts a primary control on the distribution of nutrients to a large portion of the modern ocean, which in turn regulates algal population structure and carbon uptake.The aim here is to further the understanding of oceanic carbon storage over a range of timescales in the region of the West Antarctica Peninsula, the region experiencing the most rapid atmospheric and oceanic warming in recent decades.  Here, I propose to utilize components of the biogeochemical cycle of barium (Ba) to understand and investigate different aspects of organic and inorganic carbon storage.  Ba cycling has been a focus of chemical oceanography and palaeoclimate studies for over twenty years, and can provide uniquely an insight into both organic and inorganic carbon storage.  The analyses carried out during the reintegration period will provide data suitable for testing hypotheses linking Southern Ocean circulation to global climate over a range of timescales, and linking the response in biogeochemical cycles to future climatic change.The work will be interdisciplinary, linking in other aspects of the long term monitoring programs along the WAP, such as physical oceanography, meteorology and ecology, and investigating modern and past climatic processes.  If successful, the Marie Curie grant w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Information retrieval in an integrated system for police'.

assistant: **Innovation**

The objective of IRISPOL is to develop an application for information retrieval in the Police sector.Information will consist of multimedia data stored in a central database located in the Police headquarters and retrieved from the Police stations and from Police cars. The technical objectives of the project are to improve functionality and performance of technologies involved in the project and to develop an application using such improved technologies. The business objectives are the introduction of experimental technologies resulting from R&D projects in real application, the redeployment of IRISPOL application in other areas and the quality improvement of services provided by the Police.A number of leading edge technologies resulting from previous projects, mostly developed in European Programmes, will be used; such as:- Facial Recognition. This technology will be used to code face features based on face photographs. Face features are included in the Police records and are employed to identify criminals matching a photo fit picture. Currently, the Basque Police have available a set of software libraries for facial recognition, but it is not possible to code every feature. This software is based on results from the VIDIMUS Project (Esprit P2592).- Data transmission. Morphological source coding techniques for visual data resulting from the MORPHECO Project (Race R2053) will be used in data transmission and storage. MORPHECO finished in December 1994 and its results are currently in an experimental stage.- Information retrieval focused on multimedia data. Results from the INTUITIVE project (Esprit P6593), completed recently, will be used in the application for searching and displaying multimedia data.Basic elements in the applications will be a workstation in a Police
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Integrated Theory and Observations of the Pleistocene' to be submitted under Seventh Framework.

assistant: **Abstract**

There are essentially two approaches to climate modelling. Over the past decades, efforts to understand climate dynamics have been dominated by computationally-intensive modelling aiming to include all possible processes, essentially by integrating the equations for the relevant physics. This is the bottom-up approach. However, even the largest models include many approximations and the cumulative effect of these approximations make it impossible to predict the evolution of climate over several tens of thousands of years. For this reason a more phenomenological approach is also useful. It consists in identifying coherent spatio-temporal structures in the climate time-series in order to understand how they interact. Theoretically, the two approaches focus on different levels of information and they should be complementary. In practice, they are generally perceived to be in philosophical opposition and there is no unifying methodological framework. Our ambition is to provide this methodological framework with a focus on climate dynamics at the scale of the Pleistocene (last 2 million years). We pursue a triple objective (1) the framework must be rigorous but flexible enough to test competing theories of ice ages (2) it must avoid circular reasonings associated with ``tuning'' (3) it must provide a credible basis to unify our knowledge of climate dynamics and provide a state-of-the-art ``prediction horizon''. To this end we propose a methodology spanning different but complementary disciplines: physical climatology, empirical palaeoclimatology, dynamical system analysis and applied Bayesian statistics. It is intended to have a wide applicability in climate science where there is an interest in using reduced-order representations of the climate system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a Sustainable Route to the Important Platform Chemical 3-Hydroxypropanoic Acid Using Synthetic Biology and a Geobacillus Chassis' (GEO-HPA), addressing dissemination and exploitation.

assistant: **Impact**

The environmental damage caused by the indiscriminate use of fossil fuels for chemical manufacture threatens the very future of our planet. Attention must now focus on biological routes that convert lignocellulosic biomass (LCB) into the required platform chemicals. 3-hydroxypropanoic acid (3-HP) has been ranked as the third most important chemical that can be derived from LCB by the US Department of Energy. However no commercial biological process is presently available. Current attempts are thwarted by the high cost of feedstock, low titers and yield and 3-HP toxicity.The goal of GEO-HPA is the development of a bioprocess for  3-HP production from LCB using the bacterium Geobacillus (the process organism of the UK biofuel company TMO Renewables Ltd). Geobacillus is capable of growth at high temperatures (up to 70 C), can rapidly metabolize a wide range of substrates (including pentose sugars and insoluble substrates) typically found in LCB hydrolysates and is thus capable of the simultaneous saccharification and fermentation of this feedstock. The pathways necessary production will be introduced into the Geobacillus genome using Synthetic Biology approaches, coupled with the deliberate inactivation of genes encoding competing pathways.  Culture conditions, process variables and reactor operation mode will be optimized.  The in situ removal of 3-HP and process scale-up will lead to improved 3-HP titers, yield and productivity.The project will capitalize on the extensive expertise of Dr Kumar and the unique range of ‘state-of-the-art’ tools, resources and partners (TMO Renewables Ltd) available at the host institution. It will lead to complementary exchange of capabilities and knowledge between Europe and India, and the establishment of a long lasting collaboration. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Demonstrating a 2-stroke and 4-stroke large scale ammonia marine engine' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The overall aim of the Ammonia2-4 project is to demonstrate at full scale two types of dual fuel marine engines running on ammonia as main fuel: (i) a four-stroke and (ii) a two-stroke engine. The proposed four-stroke innovation is a newbuild 10MW engine to be demonstrated in lab conditions closely mimicking real-life operations in ambient conditions. The proposed two-stroke innovation is a medium-pressure ammonia fuel injection platform that can be retrofitted onto any two-stroke marine engine available in the market today. It will be demonstrated in the project at two stages: a lab demonstration followed by retrofitting onto a container vessel of the alpha customer MSC. Both engine innovations are expected to result in at least 80% less GHG emissions (including nitrous oxide emissions), NOx emissions below IMO Tier III regulations and a negligible ammonia slip below 10ppm. By demonstrating both engine types at full scale the project partners are aiming for commercial exploitation of the project results towards more than 90% of the maritime intercontinental transport in terms of gross tonnage, including retrofits and newbuilds to enter the fleet within the next ten years. It is expected that both Ammonia2-4 innovations will lead to an annual reduction of CO2 emitted by deep sea vessels calling at EU ports by 2.3 million tons, and reduce the emissions of harmful pollutants such as SOx by 15 tons annually. The project will go beyond purely technological developments and investigate a number of non-technical aspects crucial for a successful uptake of ammonia as marine fuel: health & safety, ammonia supply infrastructure, crew training & acceptance, but also novel standardisation pathways for regulating emissions from ammonia marine engines.


**Keywords:** marine engine,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structural studies of membrane proteases' (MEMPROT).

assistant: **Innovation**

Proteases are key players in many cellular processes and come in great variety. There are essentially five different catalytic types: serine/threonine, cysteine, aspartic and metallopeptidases. Each type of active site can be found in several different folds, which suggests that active sites have been reinvented multiple times during evolution. The soluble peptidase folds have been studied in great detail, and in nearly all cases, at least one prototype crystal structure is available. In contrast, there are almost no crystal structures of integral membrane proteases, therefore their mechanistic understanding lies far behind. It is not even clear whether a specific water channel is required to transport a catalytic water molecule to the active site or whether a low concentration of water in the lipid bilayer is sufficient for amide cleavage.  Despite these uncertainties, the combined results of sequence comparisons and biochemical studies suggest that membrane and soluble proteases will probably turn out to have (a) dissimilar folds and (b) similar active sites.  However, there is no good evidence yet for a membrane-embedded cysteine peptidase, and for several membrane protease families the assignment of the catalytic type is controversial, which may be an indication for a novel type of active site. In order to broaden the spectrum of our research we are planning to acquire new skills in membrane protein overexpression, purification and crystallization which we would then apply for structural studies of membrane proteases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Structural role of protein splicing factors in promoting an active configuration of the spliceosome's RNA catalytic core'.

assistant: **Concept**

The spliceosome is a ribonucleoprotein machine that excises introns from pre-messenger RNAs. During my phD, I identified RNA ligands for the magnesium ions that catalyze these splicing reactions and showed that the spliceosomal U6 and U2 small nuclear RNAs form a structure resembling group II self-splicing intron RNAs. Although the spliceosome's catalytic core is RNA-based, numerous spliceosomal proteins promote the proper catalytic fold of this RNA core, juxtapose the reactive pre-mRNA elements with the U6 metal sites, and regulate spliceosome dynamics during the splicing cycle. Indeed, the Prp8 protein cross-links with the critical nucleotides of the catalytic RNA core and its crystal structure, reported recently by the host laboratory, revealed a cavity that accommodates the catalytic RNA core. Moreover, several helicases, such as Brr2 and Prp16, promote an active configuration of the U2/U6 RNA core and associated proteins and regulate their dynamics. The arrangement of such proteins in the assembled spliceosome and their interactions with the RNA core is presently unknown due to the lack of high-resolution structures of any spliceosomal complexes. I will study biochemically in vitro the interactions between the U2/U6 core and key proteins necessary for an active fold of the RNA core, with the goal of reconstituting and solving the high-resolution structure of a minimal active U2/U6 RNA core in complex with the reactive pre-mRNA sites and surrounding proteins including Prp8. In parallel, I will employ recent advances in cryo-electron microscopy sample preparation, imaging, and data processing, which were pioneered at the host institute, to obtain high-resolution (at least 7 Angstroms) three-dimensional reconstructions of endogenous fully assembled spliceosomes stalle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Novel automatic and stand-alone integrated pest management tool for remote count and bioacoustic  identification of the Olive Fly (Bactrocera oleae) in the field'.

assistant: **Innovation**

ENTOMATIC addresses a major problem faced by  EU Associations of Olive growing SMEs: the Olive fruit fly (Bactrocera oleae). This insect pest causes yearly economical losses estimated to be almost  €600/ha. ENTOMATIC aims to develop a novel stand-alone field monitoring system comprising: a fully autonomous trap with integrated insect bioacoustic recognition, embedded in a wireless  sensor network and supported by a spatial decision support system.The ability to quantify and make a precise control of Olive fly populations in a cost-effective way, has been a long desired goal in the Olive sector. The potential offered by ENTOMATIC has SME-AGs and their associated SMEs keen on its development. The expected benefits are the reduction of damage to olive fruit and oil production and to promote the sustainable use of pesticides .Via ENTOMATIC, olive producers will be able to track  pest population and geographical status and receive advice on precision pesticide application.The consortium is composed of  SME-AGs of Olive Producers from the EU and Turkey, and lead-user SMEs expert in Pest Management solutions. These will lead the specification, validation, protection, and use of  the results generated by the selected RTD providers expert in Entomology, Decision Support Systems, Bioacoustics, Electronics, Signal Processing, IT solutions, Wireless Communications and PrototypingENTOMATIC, is a business opportunity identified and championed by the consortium SME-AGs. This will license the IP generated in the project to the lead-user SMEs who will be in charge of production and distribution. Both parties will use their own associate and customer networks as initial commercial routes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The detection and hazard evaluation of aneugenic chemicals' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Chemicals which induce numerical chromosome changes i.e. aneugens, may represent significant environmental hazards, as such changes in somatic cells contribute to tumour progression and in germ cells to birth defects. In the case of the induction of point mutations and chromosome structural rearrangements by chemicals, such as pesticides, the major target of chemical interactions has been clearly characterised as being the DNA of the chromosomes. In contrast, chemicals which induce numerical chromosome changes, such as polyploidy and aneuploidy, may potentially interact with a diverse range of cellular targets including all the components of the mitotic and meiotic cell cycles and their associated checkpoints. Studies (including some with EU support) have demonstrated that aneuploidy is induced by a wide range of environmental chemicals. Currently, there are no defined and validated test systems and strategies for the detection and evaluation of chemicals which induce aneuploidy and this deficiency has been highlighted by the International Conference on the Harmonisation of Pharmaceutical Safety Evaluation (ICH 1995) and a variety of international and national regulatory and advisory bodies to the chemical industries. The aims of the project are to complete the development of a package of methods for the detection of chemical aneugens and to determine significance of exposure to chemical aneugens of germ cells of both rodents and humans. In the proposed project the collaboratories will: 1) Determine the significance of chemical damage to components of the cell cycle. 2) Develop and validate an in vitro methodology for the detection and evaluation of aneugenic chemicals. 3) Develop and evaluate a methodology for identifying aneugenic activity in the GI tract and compare
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SynchroniCity: Delivering an IoT enabled Digital Single Market for Europe and Beyond' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

SynchroniCity represents the first attempt to deliver a Single Digital City Market for Europe by piloting its foundations at scale in 11 reference zones - 8 European cities & 3 more worldwide cities - connecting 34 partners from 11 countries over 4 continents. Building upon a mature European knowledge base derived from initiatives such as OASC, FIWARE, FIRE, EIP-SCC, and including partners with leading roles in standardization bodies, e.g. ITU, ETSI, IEEE, OMA, IETF, SynchroniCity will deliver a harmonized ecosystem for IoT-enabled smart city solutions where IoT device manufacturers, system integrators and solution providers can innovate and openly compete. With an already emerging foundation, SynchroniCity will establish a reference architecture for the envisioned IoT-enabled city market place with identified interoperability points and interfaces and data models for different verticals. This will include tools for co-creation & integration of legacy platforms & IoT devices for urban services and enablers for data discovery, access and licensing lowering the barriers for participation on the market. SynchroniCity will pilot these foundations in the reference zones together with a set of citizen-centred services in three high-impact areas, showing the value to cities, businesses and citizens involved, linked directly to the global market. With a running start, SynchroniCity will serve as lighthouse initiative to inspire others to join the established ecosystem and contribute to the emerging market place. SynchroniCity takes an inclusive approach to grow the ecosystem by inviting businesses and cities to join through an open call, allowing them to participate on the pioneering market place enabling a second wave of successful pilots. They will strengthen the ecosystem by