RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Brain dynamics of conscious perception : does conscious perception arise in a gradual or discontinuous fashion ? Combined MEG and fMRI studies' to be submitted under Seventh Framework.

assistant: **Abstract**

Does our conscious perception of an external object arise gradually or in a discontinuous fashion? Answering this question is crucial to understand the neural mechanisms of conscious perception and its relationship with unconscious perception. This has important implications on therapeutic practice towards patients with altered consciousness. However, experimental evidence so far has been rare and contradictory. My project uses a novel approach: comparing directly the two types of dynamics, gradual or discontinuous, within the same experiment. In this experiment the quantity of perceptual information available from an image is titrated by the duration of presentation, while the possibility to become conscious of this perceptual information is affected by attentional competition with another image presented a few hundred milliseconds before (“attentional blink”). In behavioural tests I have already shown that, in this new paradigm, our subjective perception follows a combination of gradual and discontinuous dynamics. Using functional imaging I will test this original prediction: an increase in the quantity of perceptual information should be associated with a gradual increase in cerebral activity, while conscious access itself should be associated with a discontinuous jump. I will combine the advantages of magnetoencephalography (MEG) and functional MRI in order to characterize when and where in the brain these dynamic events occur to give rise to conscious perception. This project will take place in a world-class Imaging Centre in Paris (MEG, EEG, fMRI), with international experts in MEG studies of consciousness and attention. I will bring a particular fMRI expertise acquired during my Marie Curie fellowship in London in one of the most renowned Imaging Centres (FIL). T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Breaking the Nyquist Barrier: A New Paradigm in Data Conversion and Transmission' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Digital signal processing (DSP) is a revolutionary paradigm shift enabling processing of physical data in the digital domain where design and implementation are considerably simplified. However, state-of-the-art analog-to-digital convertors (ADCs) preclude high-rate wideband sampling and processing with low cost and energy consumption, presenting a major bottleneck. This is mostly due to a traditional assumption that sampling must be performed at the Nyquist rate, that is, twice the signal bandwidth. Modern applications including communications, medical imaging, radar and more use signals with high bandwidth, resulting in prohibitively large Nyquist rates.Our ambitious goal is to introduce a paradigm shift in ADC design that will enable systems capable of low-rate, wideband sensing and low-rate DSP.While DSP has a rich history in exploiting structure to reduce dimensionality and perform efficient parameter extraction, current ADCs do not exploit such knowledge.We challenge current practice that separates the sampling stage from the processing stage and exploit structure in analog signals already in the ADC, to drastically reduce the sampling and processing rates.Our preliminary data shows that this allows substantial savings in sampling and processing rates --- we show rate reduction of 1/28 in ultrasound imaging, and 1/30 in radar detection.To achieve our overreaching goal we focus on three interconnected objectives -- developing the 1) theory 2) hardware and 3) applications of sub-Nyquist sampling.Our methodology ties together two areas on the frontier of signal processing: compressed sensing (CS), focused on finite length vectors, and analog sampling. Our research plan also inherently relies on advances in several other important areas within signal processing and co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Human genetic determinants of invasive group A streptococcal host-pathogen interactions' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Group A streptococcus (GAS) is a major, human specific, bacterial pathogen. Most people suffer from mild infections, while only a few develop invasive GAS (iGAS) infections. These cases of iGAS infections are unexplained as they strike otherwise healthy people. The human specificity of GAS and the interindividual variability upon infection with GAS are poorly understood. My proposal aims to close both knowledge gaps: I hypothesize that single-gene defects of antistreptococcal immunity increase susceptibility to human-specific GAS virulence factors in some people, thereby underlying their iGAS infections. I propose an innovative framework to unravel iGAS pathophysiology in humans, by applying a strategy to integrate the studies of human genetics and host-pathogen interactions at the molecular level. This project focuses on patients suffering from iGAS infections. Most patients have been enrolled, sampled, and whole exome sequencing (WES) performed. Additional patients will be recruited. The human gene(s) underlying iGAS infections will be identified using complementary WES-based approaches. The discovered inborn error(s) of immunity to GAS and the host-pathogen interactions will be dissected at the molecular, cellular, tissue, and whole-organismal levels, including with patients’ cells and clinical GAS strains.The immediate availability of patients’ genetic data provides a secure starting point for an efficient implementation of this proposal. Preliminary analyses have yielded two promising candidate genes. Access to patients’ specimens and clinical GAS isolates offers an exceptional opportunity to characterize patient-specific host-pathogen interactions. Thus, we are in a unique position to discover the first human genetic determinant(s) of iGAS host-pathogen interactio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Evaluation of a therapeutic vaccination strategy for hiv infection (THERAVAC)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Highly active antiretroviral therapy (HAART) dramatically decreases in HIV-related morbidity but does not eradicate HIV and is associated with severe toxicities. To improve clinical management of HIV infection the Theresa Demonstration Project will evaluate a new strategy of immunotherapy using highly attenuated poxvirus-based anti-HIV vaccines (NYVAC/MVA) in phase I/II clinical trials in HIV-infected patients. The objectives of the Project are to demonstrate1) the safety of these vaccines in HIV-infected patients under HMRT,2) their capacity to increase numbers and breadth of HIV-specific T cells in order to restore a strong immune control of HIV, compared to the Canary pox vaccine,3) to allow prolonged interruptions of treatments. A principal deliverable of Theresa is to show that the collaboration of new vaccines produced in Europe and antiretroviral can limit time on therapy and associated drug toxicity and costs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advanced CataLysts for H2-free hydrodeoxygenation - a rEVolutionary approach Enabling pRactical biomass upgrading to bioFUEL' (CLEVER-FUEL) targeting Horizon Europe.

assistant: **Abstract**

CLEVER-FUEL proposes a revolutionary approach for low-carbon fuels production paving the way for a direct “waste to biofuels” conversion strategy. The project will develop a completely novel route to produce deoxygenated hydrocarbons – highly important chemical compounds in the biofuel and biochemical industries - via designing of advanced catalysts for the H2-free hydrodeoxygenation (HDO) process. This ground-breaking route take the edge over current biomass upgrading approaches which rely on high-pressure hydrogen – an expensive resource whose manipulation, transport and storage imposes serious limitations and represent a bottleneck to the commercial deployment of this technology. CLEVER-FUEL will create new chemistry and reaction engineering concepts to circumvent this handicap by using the cheapest and safest possible hydrogen source: water. The overriding goal is to create a new conversion pathway by using water as hydrogen donor and advanced multifunctional catalysts able to catalyse water reduction and hydrodeoxygenation simultaneously yielding oxygen-free biofuels. Such multifunctionality resolves the problem of oxygen-rich bio-compounds upgrading in a single reactor under mild conditions and avoiding the external supply of high-pressure hydrogen thus opening a completely new research avenue for biomass conversion technologies. CLEVER-FUEL will combine unique multifunctional catalysts with advanced operando characterisation techniques to provide a rational strategy for catalysts design. In addition, novel reactor concepts based on microchannel catalytic systems will be implemented to facilitate process intensification.CLEVER-FUEL represents a forward-thinking concept in catalysis and reaction engineering and it is conceived to open new horizons in bioenergy rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Addressing key challenges for forecasting climate change effects on biodiversity: an assessment of dispersal limitation, priority effects and intra-species trait variation in range dynamics' (KeyDynamics) under Horizon 2020.

assistant: **Objectives**

Active adaptation to current climate change related threats and the utilization of possible opportunities is hindered by three key limits in our understanding of the reaction of species and associated ecosystem services to climate dynamics. There is limited knowledge i) to which extend current species’ distributions are in equilibrium with their climatic niches, ii) how necessary range shifts are modulated by complex biotic interactions, which may depend on arrival order in a community i.e. “priority effects”, and iii) if ‘species’ is the adequate unit for impact assessments and predictive modelling given large within-species variability in adaptive capacity. This project will address all three key limits at once by applying novel methodology tracking species range shift dynamics through time since the Last Glacial Maximum. The project improves established migration models and utilizes newly available high-resolution vegetation community information to quantify biotic interactions comparing functional similarity between arriving species and the established community. Pollen and macrofossil records will be used for independent model evaluation and to identify responsible drivers for time lags between climate suitability and actual arrival of species at sites across Europe. Extending the approach accounting for differently adapted ecotypes within species will identify effects of intra-species variation on range dynamics.The proposed research has the potential to greatly enhance our understanding of climate-biosphere interactions, and results will have immediate practical applicability. Strong contributions to fundamental ecological theory are to be expected. The candidate’s experience in geospatial modelling and theoretical ecology, together with the host’s expertise in e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Banking and Climate Change'.

assistant: **Objectives**

Climate change is one of the key societal challenges of our generation, affecting every country, every firm, and every person on this planet for decades to come. More than half of carbon emissions arise from bank-dependent sectors of the economy; and a large part of renewable energy production is financed by banks. The banking sector plays a crucial role for lending to firms and households, for the issuance of securities, for project financing, and for mergers and acquisitions. Yet, the role of banks in addressing climate change is not yet well understood. The goal of this project is to provide a fundamental understanding of the role of the banking sector in addressing climate change. The project will take a holistic view and analyze several channels through which the banking sector plays a central role in addressing climate change: the role of laws and regulations, the role of governance mechanisms in the banking sector, the role of state-owned banks, as well as the interaction between public markets and banks.  I pursue this research agenda in two parts. The first part focuses on the role of the banking industry for firms, while the second part focuses on the role of the banking industry for households. Both parts will analyze key agency and financial constraints that can impede the provision of financing for long-term investments that are at the heart of climate finance.  This project will shape our understanding of the role of the banking sector in addressing climate change. It will empirically analyze key channels, advance the methodological toolkit that can serve as the basis for future research in this area, and create unparalleled new data sets tailored to analyzing the role of the banking sector in addressing climate change. The results of this project can help
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Glucose Metabolism and Breast Density: a Pathway for Breast Cancer Etiology' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Breast cancer is the most common cancer in women, and a leading cause of cancer death in Europe. We propose to improve understanding of breast cancer etiology by investigating the metabolic effect of glucose and genetic variants implicated in glucose metabolism and breast mammographic density, one of the strongest known risk factors for breast cancer. There is increasing evidence that obesity and diabetes mellitus are associated with increased risk of breast carcinomas. Biological and epidemiological data provide support for a role of glucose and other factors related to glucose metabolism, such as insulin and insulin-like growth factors (IGFs), in breast cancer development. However, it is still not clear how impaired glucose metabolism exerts its influence on breast cancer risk.Mammographic density (MD) refers to variations in the breast among women that reflect differences in tissue composition. Women who have >75% of their breast area as dense tissue have a risk of breast cancer 3-6 times great er than women of the same age with zero area representing one of the most powerful predictors of breast cancer. The proposed study aims to investigate whether glucose metabolism influences risk of breast cancer through direct effects on proliferative activity and quantity of stromal and epithelial tissue in the breast, that is reflected in mammograpic density. Thus, we postulate that genetic and metabolic factors related to glucose metabolism influence breast tissue composition through effects on the level s of exposure to growth factors such as IGF-1 that are mitogens in the breast resulting in greater quantities of stromal and epithelial tissue in the breast, increase susceptibility to carcinogens, and risk of breast cancer. The long term goal of the propos ed investigation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Investigating the role of the long noncoding transcriptome in chromatin replication'.

assistant: **Innovation**

A major shift in our conception of genome regulation has emerged in recent years. It is now obvious that the majority of cellular transcripts do not code for proteins, and a significant subset of them are long RNAs (lncRNAs). My lab and others have shown that lncRNAs regulate genome function and gene expression, and that alterations in lncRNAs are inherent to disease, including cancer. However, our understanding of the roles of lncRNAs and their underlying molecular mechanisms are still extremely poor.Among all the mechanisms reported, the evident connection between lncRNAs and the chromatin places them at the center of cell biology. During their cycle, cells must undergo faithful DNA replication to ensure that an exact copy of their genetic content is passed on to their daughters. Throughout this tightly regulated process chromatin must be disrupted and reconstituted, and it determines where and when replication takes place. If replication is deregulated, cells can proliferate uncontrollably and suffer loss of genome integrity. Our recent findings implicate lncRNA in the process of DNA replication, representing a novel aspect of genome regulation that places lncRNAs at the focal point of cancer biology. To delve deeper into these findings I aim to:1. Identify the role of lncRNAs in the replication of the chromatin2. Dissect the molecular mechanism by which lncRNAs function in this process and3. Explore the role of these lncRNAs as cancer drivers and their potential as therapeutic targets.I will apply tools that we have generated in recent years, as well as new ones, including approaches to identify lncRNAs associated with replicating chromatin, novel lncRNA-tailored CRISPR applications, and the latest methodology for functional study and targeting of long noncoding tra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Support to SET Plan Implementation Working Group and European Technology and Innovation Platform for Ocean Energy'.

assistant: **Innovation**

SEETIP Ocean’s mission is to enhance cooperation and collaboration amongst stakeholders both inside and outside of the European ocean energy sector. This mission is broken down into 6 objectives:1.Maximise European scientific excellence in ocean energy2.Make sustainability and the Just Transition an integral part of ocean energy’s development3.Build a deeper understanding of how ocean energy can optimally fit into the wider energy, industrial & infrastructure systems and planning systems, and help realise this integration4.Empower the SET Plan Ocean Energy Implementation Working Group and other public authorities by monitoring, analysing and reporting annual commentary on the sector’s progress5.Reinforce and expand the ocean energy network through strong outreach actions6.Continue the work of ETIP Ocean and SET Plan Ocean Energy IWG after the project endsOcean energy can power European society and economic life with electricity that is renewable, dependable and in harmony with local communities and environments. To reach this potential, sectoral stakeholders must collaborate, share knowledge and avoid duplication of efforts. SEETIP Ocean will do this by supporting the activities of both the European Technology & Innovation Platform for ocean energy (ETIP Ocean) and the SET Plan Ocean Energy Implementation Working Group.The project’s objectives will be achieved through coordination actions bringing individuals and organisations together to exchange knowledge, create new knowledge and build more and deeper connections. Widespread knowledge-sharing will be facilitated via webinars and workshops. Based on these exchanges, SEETIP Ocean will publish accessible studies and reports that will be widely disseminated across and beyond the ocean energy sector.The SET Plan Ocean Ene