RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'FIRST EUROPEAN MEETING ON MOLECULAR AND CELLULAR COGNITION' (EUROMEMO) targeting Sixth Framework.

assistant: **Abstract**

Molecular and Cellular Cognition is a rapidly moving field which is at the crossroads between basic neurobiology and clinical neuroscience. At the end of 2002 a new scientific organisation, the Molecular and Cellular Cognition Society (MCCS, www.molcellcog.org), was established with the aim of facilitating exchanges between laboratories in this research field and to promote neuroscience at the general public level. Here, we propose to organise the first European Meeting, as a satellite of the Federation of European Neuroscience Societies (FENS) meeting, to be held in Lisbon on July 8-9, 2004. This meeting will be organised by three prominent European scientists in this field, Seth Grant (University of Edinburgh, UK), Isabelle Mansuy (University of Zurich, Switzerland) and Riccardo Brambilla (San Raffaele Research Institute, Italy) in collaboration with the President of MCCS, Alcino Silva (UCLA, USA). Three additional members of the MCCS council will also be consulted for the organisation of the meeting: Paul Chapman (Merck, UK), Yadin Dudai (Weizmann Institute, Israel) and Cristina Alberini (Mount Sinai, USA). The meeting, which will be extensively advertised on both MCCS and FENS web sites and on the most important neuroscience journals, will be held in two days. On day 1, the first oral presentation session will be followed in the afternoon by a single poster session. On day 2, two oral presentation sessions will be scheduled, for a total of approximately 30 speakers, 100 posters and 300 participants. In addition to invited speakers coming from Europe, Japan and USA, approximately one third of the oral presentation will be selected from posters. Particular attention is made to women and to scientists coming from Eastern Europe. The meeting will also be an ideal forum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'PRoduction of an innOvative Millifluidic dEvice for TEsting of new prObiotics' (PROMETEO) targeting Horizon Europe.

assistant: **Abstract**

Over the last decades, the gut intestinal microflora and other microbial communities present in our body raised a strong interest in the health research domain as it was discovered their possible relation to the pathophysiology of major organs and systems. Gut epithelial cells, together with our resident microbiota, are involved in the modulation of the host immune system and represent the first line of adsorption of drugs and nutraceuticals. In parallel to microbiota studies, a great effort has been devoted to assess the role of the “probiotics”, live microorganisms that, administered in adequate amounts, are able to confer a benefit to the host health. Probiotics are currently widely used in the prevention/treatment of many diseases. One critical point that is still an issue in the characterisation of new potential probiotics is the difficulty in mimicking with high reliability the gut microenvironment condition using animal models or the current in vitro tools, poorly representative of the real in vivo situation. This gap motivates the need for the development of alternative research tools, such as the fluidic devices, to study the mechanisms at play in human gut microenvironment and contribute to the success rate of expensive, risky and time-consuming pre-clinical and clinical trials. In this frame, our PROMETEO project aims to perform the technical and commercial feasibility of an integrated probiotic/gut epithelium/immune system millifluidic platform, based on a patented organ-on-a-chip technological device, providing the basis for a new generation of innovative solutions for probiotics/drug development. PROMETEO will be run by a consortium between Politecnico di Milano and AAT-Advanced Analytical Technologies, a forefront SME specialized in promoting innovation i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Upgrade of the Centre of Excellence LignoSilva' in the context of a Horizon Europe call.

assistant: **Objectives**

The LIGNOSILVA Centre of Excellence for Forest-based industry stands for a systematic and structural change in the research landscape of the forest-based sector (FBS). The EU has made a strategic turn towards a circular bioeconomy, striving for a low-carbon society based on renewable sources, including wood biomass. It requires to transfer of knowledge and brings new innovation into FBS practice. FBS research landscape in Slovakia - as well as in countries with similar political histories - is highly fragmented and loses much of its potential due to insufficiently organised structures and strategies. Moreover, it is not linked to collaboration with Western/Northern EU countries. In the long run, this affects the entire value chain. The overall objective of the CoE is to contribute to overcoming these shortcomings by upgrading the existing LignoSilva Center of Excellence (CoE). The essence of upgrade lies in institutional reform that introduces European science management standards, increases excellence, expands research capacities, digital transformation based on the implementation of Forestry 4.0 and Pulp & Paper 4.0 into CoE research-innovation activities, support for open science and more efficient knowledge transfer to FBS.The main goal is to bring excellent research and applicable innovation into FBS in three research areas:-Intelligent technologies and systems supporting wood production and industrial wood processing.-Pulp and paper technologies for biodegradable packaging and special papers development with multifunctional properties  -Recycling technologies and use of cellulose sludge and wood ashCoE LignoSilva's objective will be reached by concentrating the research and infrastructure capacities of the National Forestry Centre and the Pulp and Paper Research I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Modular Power BUS for space vehicles'.

assistant: **Innovation**

The rapid growth of the private satellite launchers sector is leading the space race. With the privatization of the sector all of the companies are racing for a more efficient and reliant way to set satellites in orbit. In space terms, efficient usually means weight saving which is the main objective that this project addresses. Weight saving will not only mean reducing the cost per Kilogram on each launch, but it will open a whole new range of possible missions with current or future, next generation launch vehicles.Having detected the current needs for power management in the Launcher vehicle industry, the MPBUS project is proposed as a technology to revolutionize power management in current and future Launcher Vehicles.The MPBUS Project is committed to develop a new power bus architecture combining ejectable batteries with the main bus through intelligent nodes. These nodes are able to communicate between them and a battery controller using an improved, data over DC line technology, expected to reduce the total weight in 2 main areas: improving the use of the batteries and reducing the total weight due to harness.The consortium is formed by two Spain SMEs, one Israel SME, and one Belgium Research Center, all of the participants have previous experience in participation in RTD European projects.Different stakeholders are involved representing various space or high-tech related sectors: aerospace electronic control system developer (NASP), engineering (JMP Ingenieros),  hardware space qualification (ULG_CSL), multiplex communication networks (YAMAR).Taking into consideration the industrial dimension of the MPBUS project, specific taks will be developed for results exploitation taking into consideration the specific impact for each participant enlisted in exploitation s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Noise in gene expression as a determinant of virulence of the human pathogen Streptococcus pneumoniae' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Not all cells in bacterial populations exhibit exactly the same phenotype, even though they grow in the same environment and are genetically identical. One of the main driving forces of phenotypic variation is stochasticity, or noise, in gene expression. Possible molecular origins contributing to noise in protein synthesis are stochastic fluctuations in the biochemical reactions of gene expression itself, namely transcription and translation.The driving hypothesis of this application is that the human pathogen Streptococcus  pneumoniae utilizes noisy gene expression to successfully colonize and invade its host. To test this supposition, the total amount of noise in key regulatory networks for virulence factor production will be quantified. Using natural and synthetic bistable switches as highly sensitive probes for noise, in combination with state-of-the-art single-cell imaging, microfluidics and direct transcriptome sequencing, the molecular mechanisms underlying noise generation in S. pneumoniae will be determined. By constructing strains with altered levels of phenotypic variation, the importance of noisy gene expression in S. pneumoniae pathogenesis will be tested.S. pneumoniae is a leading cause of bacterial pneumoniae, meningitis, and sepsis worldwide. The molecular mechanisms that cause switching of S. pneumoniae to its virulent states are barely understood, although it becomes increasingly clear that noise-driven phenotypic variation plays an important role in pneumococcal pathogenesis. Therefore, understanding the molecular origins of phenotypic variation in S. pneumoniae might not only provide novel fundamental insights in gene expression, but also result in the identification of new anti-pneumococcal targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'CC-LEGO: robust protein blocks to build cages and layers' (CC-LEGO), addressing dissemination and exploitation.

assistant: **Impact**

The design of novel proteins offers unprecedented advantages for human health, such as improved vaccines, drug delivery and novel therapies (e.g. a flu inhibitor, treatment of Alzheimer’s). The state of the art of de novo self-assembling protein nanomaterials is based on the design of protein-protein interfaces. However, due to the complex interplay of numerous weak interactions at the interface the success rate of designed assemblies is currently below 10%. This proposal aims to increase the success rate of designing large protein assemblies, by using coiled-coils (CC) at the interface. CCs are some of the best understood protein motifs and can be designed with high success rates (>50%). A set of well-defined building blocks (CC-LEGOs) will be created by rigidly fusing CC bundles and natural oligomerization domains. Due to precise control of crossing angles enabled by the rigid fusion we expect that CC-LEGO structures will have the high design success rate and high solution homogeneity needed for further applications. A toolbox of CC-LEGO blocks will be designed and experimentally tested, capable of forming cages (tetrahedra, cubes, dodecahedra) as well as open 2D lattices.The experienced researcher (ER) will gain new programming and wet lab skills for protein design through performing world-class research at one of the world’s top universities in a group of a world leader in this field. The expected high impact publications and networking opportunities, coupled with the acquired soft skills in project writing, management, leadership and communication will ensure ER’s competitiveness and enable a successful start of his independent career.Another important impact of the project is the transfer the protein design know-how from the University of Washington to the Sloveni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Understanding the Hardness of Theorem Proving' in the context of a Seventh Framework call.

assistant: **Objectives**

This project aims to explore the fundamental question in computer science and mathematics regarding what computational problems can feasibly be solved on a computer. More specifically, we want to study algorithms for proving logic formulas as well as impossibility results for this problem.Proving formulas in propositional logic is a problem of immense importance both theoretically and practically. On the one hand, this computational task is believed to be intractable in general, and deciding whether this is so is one of the famous million dollar Millennium Problems (the P vs NP problem). On the other hand, today automated theorem provers, or so-called SAT solvers, are routinely used to solve large-scale real-world problem instances with even millions of variables. This contrasts to that there are also known small example formulas with just hundreds of variables that cause even state-of-the-art SAT solvers to stumble.The main objectives of our project are as follows:(1) Understand what makes formulas hard or easy in practice by building and studying better theoretical models of the proof systems underlying SAT solvers, and testing the predictions of these models against empirical data.(2) Gain theoretical insights into other crucial issues in SAT solving such as memory management and parallelization.(3) Explore the possibility of basing SAT solvers on stronger proof systems than are currently being used.(4) Clarify the theoretical limitations of such enhanced SAT solvers by studying the corresponding proof systems, which are currently poorly understood.We see great opportunities for fruitful interplay between the fields of proof complexity and SAT solving in this area, as well as between theoretical results and practical implementations. We believe that resolving the que
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Chromite Record of Mafic Crustal Growth' under Horizon Europe.

assistant: **Concept**

Understanding Earth's crustal growth is crucial to understanding the evolution of its tectonics, the birth of the first continents, and the fundamental changes that transformed Earth into a habitable planet. However, much of our understanding of Earth's crustal growth is predicated on a single mineral - zircon - that is strongly biased towards detecting felsic crustal growth. This is particularly problematic for the early Earth, where average crustal compositions were far more mafic than today, and the very first protocrust may be entirely undetectable using conventional methods. I propose to access the mafic to ultramafic crustal growth record using detrital chromite preserved in sedimentary rocks from Archaean Cratons. Like zircon, chromite chemical compositions reflect the magmas that they crystallised from, and can be used to identify the provenance of the mafic portions of a sedimentary rock. Furthermore, they can be dated using Re-Os isotopes, to identify the age of eroded mafic terranes. This project has three main objectives:1. Develop techniques to identify the age and composition of chromite sources in ancient sedimentary rocks.2. Use a range of detrital chromite samples from sedimentary sequences in the Superior Craton, to reconstruct a mafic-ultramafic crustal growth curve for the craton.3. Search for evidence of Earth's mafic protocrust in some of the oldest known chromite-bearing sedimentary rocks.These achievements will open a new avenue for studying sedimentary provenance, unlock the archive of mafic crustal growth throughout Earth history, and provide insights on the nature and survival of Earth's earliest crust. The techniques developed will be broadly applicable, paving the way for a better understanding of Earth's crustal evolution.


**Keywords:** c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Definition of the protein components of the FCA/FY complex in Arabidopsis thaliana' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The autonomous promotion pathway plays a major role in controlling the floral transition in Arabidopsis. Its main function is to down-regulate RNA levels of the floral repressor, FLC. The Dean lab has cloned two components of this pathway, FCA and FY, which encode an RNA-binding protein and a homologue of a yeast protein required for mRNA 3'-end-processing and polyadenylation respectively. They have recently shown that FCA/FY proteins interact physically and regulate the alternative processing of the FCA tr anscript. Since FCA has no homology to any known component of the core polyadenylation machinery, it might be a regulator of 3'-end formation, whereas FY seems to be a conserved component of the 3'-end processing machinery.The characterization of Arabidop sis FCA/FY complex will help to elucidate general questions about the composition of complexes regulating RNA 3'-end formation in eukaryotes. We expect to define the components of the FCA/FY complex by means of multidisciplinary proteomic approaches. The FY yeast homologue (Pfs2p) interacts with Yshlp, Fiplp, and RNA14p. We shall first clone Arabidopsis orthologues of Yshlp, Fiplp, and RNA14p, and we will test if the FY protein interacts with them by GST pull-down assay. Secondly, we will also identify other components of the FCA/FY complex by yeast two-hybrid experiments using FY as a bait.Positive clones will be cloned into His-tagged vectors for efficient in vitro transcription/translation and co-immunoprecipitation experiments will be carried out with GS T-tagged FY protein. Finally,we will express FCA and FY-tagged proteins with TAP and HA epitopes in cultured Arabidopsis cells (both under the control of 35S and native promoters) and in Arabidopsis transgenic plants (under the control of native promoters) for t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Rapid identification and antibiotic / antifungal-agent susceptibility testing by fourier-transform infared - ft-ir - and raman spectroscopy' (MIDAS).

assistant: **Concept**

Development of Fourier-Transform Infrared (FT-IR) and Raman spectroscopic techniques for rapid identification and antibiotic/antifungal-agent susceptibility testing of clinically relevant micro-organisms, enabling full clinical microbiological analysis of patient material within 12-24 hours.FT-IR and Raman methods will be developed that will enable the recording of spectra of micro-organism microcolonies of the order ~ 103 cells. Methods of spectral analysis will be developed by which classification of micro-organisms on the basis of these spectra will be possible. This will considerably speed up routine clinical microbiological analysis of patient material when compared to present day practice. Rapid analysis is of utmost importance in life threatening conditions such as sepsis, and for the containment of contaminations with drug resistant micro-organisms, such as multidrug resistant staphylococcus aureus. Characterisation of fastidious micro organisms will also greatly benefit from techniques that require only a small number of cells.The research activities are grouped in 4 tasks:1. Standardisation of techniques and development of dedicated instrumentation2. Basic research addressing the effect of culturing condition, colony heterogeneity, and the presence of drug-resistance mechanisms on FT-IR and Raman spectra of micro-organisms3. Methodology development: development of vibrational spectroscopic techniques for micro-organism identification and antibiotic/antifungal-agent susceptibility testing (MIDAS). This includes the establishment of databases of Raman and FT-IR spectra of clinically relevant micro-organisms, development of dedicated software for spectral analysis, development of drug-susceptibility tests, minimisation of the number of cells needed for characteri