RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Sexual selection under changing conditions and environments' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Sexual selection has been largely assumed to be static and to always favour the most exaggerated trait. However, changes in the ecological or social environment can modify the strength and direction of sexual selection (e.g. favouring flexibility in female preferences). Unfortunately, how sexual selection and environmental variability interact is still poorly understood as evidence is scarce and incomplete. The first objective of the present project is to assess the direction, strength and outcome of sexual selection under different environmental conditions in terms of parasite prevalence, population density and weather by analysing long-term databases (including breeding success and male sexual traits and condition of thousands of individuals from nine British populations over more than 15 years) in the Red Grouse Lagopus lagopus scoticus. Secondly, I will experimentally prove for the first time in a wild species at a population level that changes in the ecological environment can modify sexual selection. In two different grouse populations, three sub-areas will be selected and increased nematode load, nematode removal or control treatments will be applied to all individuals occurring in those areas. If sexual selection increases under restrictive conditions, I predict stronger selection for male traits in populations with larger parasite loads (at correlative and manipulative levels), in populations living at high densities and in populations subjected to harsher weather conditions (low winter-spring temperatures and high rainfall). Thirdly, grouse females will be challenged with increased loads of nematodes in order to experimentally study the effect of health status on mate choice. Theory predicts that females in good condition should have more attractive mates comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Indigeneities in the 21st century: From ‘vanishing people’ to global players in one generation' (IndiGen).

assistant: **Concept**

10 years after the adoption of the United Nations Declaration on the Rights of Indigenous Peoples in 2007, indigenous stakeholders act as global players in arenas such as the UN Convention on Climate Change, the Dakota Access pipeline in the USA, and the Humboldt-Forum in Berlin. Yet, until the 1960s, anthropological inquiries considered the same people as ‘vanishing’ and doomed to disappear. The so-called Indigenous Renaissance presents a remarkable phenomenon of late (post)modernity. How can this surprising process be understood and explained? The objective of this project is to study how indigenous actors evolved from ‘vanishing people’ to global players. The project is located at the disciplinary intersections between anthropology, art, history, philosophy, and politics; and aims at making a future-oriented contribution to (re)emerging indigeneities and the (re)negotiation of their (post)colonial legacies in and with Europe. While the label ‘indigeneity’ circulates globally, it is also defined as a place-based marker of identity. This project breaks new ground by incorporating both dimensions – global circulation and local experience – in a common framework. It does so by studying entangled indigeneities as transregional and transcultural formations along the transpacific intersections between North and South America, Australia and the South Pacific. By untangling these intersections through museums as research sites and laboratories, the project’s sub-objectives are: 1. to historically identify the moments and processes through which indigenous people became re-ascribed through anthropological discourses and their involvement therein, 2. to ethnographically study the ways and forms in which indigenous people appropriate these external ascriptions for self-insertion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Development of superhard B-C-N coatings with the diamond structure for wear applications'.

assistant: **Concept**

Foreseen ResultsThe experience in developing special hardmetal substrates and underlayers as well as seeding them with nano-grained diamond and studying the superhard coatings has been gained at Moscow State University and Laboratory of Advanced Materials, Russia. The knowledge in the PCVD of thin coatings by use of boron-organic precursors and investigations of their composition and structure has been gained at the Max Planck Institute for Metals Research, Germany. Various techniques for testing physical, mechanical and protective properties of the coatings are widely employed at the University of Hull, Great Britain. The joint research activity of the scientists, having a vast experience on various aspects of developing superhard coatings, will ensure the objectives of the project are fulfilled.At present, plasma chemical vapor deposition (PCVD) is employed for fabrication of coatings composed of superhard compounds (diamond and cubic boron nitride) for wear applications. Diamond has extremely high hardness, however it cannot be used as a tool material for machining of ferrous metals because of its poor chemical resistance with regard to Fe, Co and Ni at elevated temperatures. Cubic boron nitride (c-BN) can be employed for machining of ferrous metals, however, its hardness is considerably lower than that of diamond. Therefore, the synthesis of compounds, which would possess the properties of both diamond and c-BN, i.e. superhard ternary phases in the B-C-N system with the diamond crystal lattice, appears to be very promising. This could make entirely new types of superhard materials possible providing the unique combination of high hardness, chemical inertness and other properties complementing those of diamond and c-BN. These materials are expected to have outstandin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Targeting the HIV-1 Nucleocapsid Protein to fight Antiretroviral Drug Resistance' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

AIDS is one of the most serious pandemic diseases of the modern era. Although current therapies based on targeting key processes of the HIV replication cycle are potent and selective, several clinical failures are recorded due to the emergence of drug resistance. Hence, there is an urgent need for novel drugs and alternative therapeutic strategies.The objective of the THINPAD proposal is to discover and develop novel anti-HIV agents targeting the HIV nucleocapsid protein(NC), which is one of the most conserved sequence within HIV strains and is highly required for HIV replication, being therefore a primary target to overcome antiretroviral drug-resistance. The proposal originates from the successful FP6 TRIoH project and presents a multidisciplinary approach to develop anti-HIV drugs, ready for early clinical trials, that could be resistant to viral mutation since targeting a highly conserved sequence.The consortium consists of experts in the anti-HIV field which have an extensive expertise in targeting NC. Partner 1 has studied the NC dynamics and discovered small molecule NC modulators by in silico approaches. Partner 2 has developed biophysical methods to monitor the NC functions and the interaction with small molecules. Partner 3 developed a complete approach of biochemistry-, retrovirology- and microscopy-based techniques to monitor NC during HIV assembly, maturation and reverse transcription. Partner 4 is a SME founded by scientists who participated in the development of Raltegravir, which will have a leading role in the project together with Partner 5 (SME) by driving the discovery phase and pre-clinical investigation, favouring the translation of results into innovative applications for health.It is worth noting that the consortium already possesses small molecu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Wedding bells or bedding wells? Lexical and semantic influences on phoneme binding' (SEMBIND).

assistant: **Concept**

This multidisciplinary project examines the mechanisms in the mind and brain that underpin phoneme binding. We explore how knowledge of the sounds and meanings of words prevents their phonemes from recombining (so that errors such as ‘bedding wells’ for ‘wedding bells’ are avoided). Phoneme binding plays a fundamental role in understanding and producing running speech, but the underlying processes are not widely studied. We take advantage of recent methodological and theoretical advances, many of which arise from our own studies, in a programme of research designed to uncover the interactive semantic and phonological processes that underpin this process. We use three complementary techniques – neuropsychology, experimental studies of healthy participants and transcranial magnetic stimulation (TMS) – which yield complementary information. (i) Patients with semantic dementia reveal the way in which selective impairment of conceptual knowledge affects the ability to maintain sequences of speech sounds that make up words. For the first time, we compare patients on several different tasks, tapping verbal short-term memory, rapid reading and verbal memory in the absence of overt speech, to establish whether the same underlying processes are at work. (ii) We undertake a similar comparison of different tasks in healthy participants, using mixed lists containing both words and nonwords, as these stimuli have been found to elicit more phoneme recombinations for words in our past research. (iii) We adopt the highly novel approach of teaching people either the meanings or just the sounds of new words in order to examine the separate effects on phoneme binding. (iv) TMS studies of healthy volunteers allow us to examine the impact of temporarily disrupting processing within brain are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Novel water splitting catalysts for efficient alkaline electrolyzers' under Horizon 2020.

assistant: **Concept**

Renewable energies such as solar and wind are intermittent and require efficient storage methods. One of the most promising methods for renewable energy storage is water splitting, which converts these energies into hydrogen fuel. Solar or wind-driven water splitting can be done using electrolyzers, and alkaline electrolyzers are potentially scalable because they do not use precious metal catalysts. However, current alkaline electrolyzers employ catalysts that have low efficiencies and are prone to corrosion. This project aims to apply several novel classes of water splitting catalysts developed in our ERC Starting Grant project in alkaline electrolyzers. The catalysts are inexpensive and have higher energy efficiencies than those employed in commercial alkaline electrolyzers. They are potentially more stable as well. The goal of the project is to provide technology demonstrators for the use of these catalysts in alkaline electrolyzers, which is expected to result in higher efficiencies and stability at a similar cost.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Biocatalytic cascades to access valuable building blocks', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The aim of this project is to provide training in the multidisciplinary fields of organic chemistry, biocatalysis, molecular biology, biochemistry and microbiology to design and develop artificial cascades by combining various types of enzymes such as L-amino acid oxidades, alcohol dehydrogenases and lyases. This is a truly competitive, innovative and timely field in which to work, and for sure the results derived from this cutting-edge project will be published in top ranked journals contributing to European Excellence.The project is expected to make a major contribution to replace traditional chemical manufacturing which relies in highly toxic, expensive and stoichiometric reagents, many steps and toxic solvents with so-called “white biotechnology” which employs powerful natural biocatalysts such as enzymes or whole cell microorganisms that allow the combination of several steps in one-pot without isolation of intermediates (cascade reactions) establishing environmentally benign and sustainable chemical processes for the preparation of optically active valuable compounds and minimizing the wastes. The research project will be divided in three main research objectives: (i) Enzymatic cascades leading to aminoacids to hydroxyacids: Novel enantioselective routes for the preparation of enantiopure hydroxyacids, (ii) Biocatalytic cascades leading to trans-coumaric acid derivatives, (iii) Redox-neutral cascade coupling of lactate to phenol via C-C bond formation. Applications to natural product synthesis.The optimal development of the project is guaranteed by the high quality of the host institution (University of Graz) and the supervisor (Prof. Wolfgang Kroutil). The host institution owns all the facilities and infrastructures that are required for the performance of this i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Strain-stiffening vascular graft with outstanding compliance'.

assistant: **Innovation**

Cardiovascular diseases are one of the major causes of death in the EU and appropriate treatment remains challenging and expensive. Often, the only treatment option is the replacement of a native blood vessel, for example if a coronary artery bypass is needed. Although patient-derived vascular grafts remain the gold standard as a replacement of the original vessel, alternatives have to be found, as donor material is limited. Currently available synthetic grafts have several drawbacks in comparison to native blood vessels. The major drawback is the mismatch between the mechanical properties of the native vessel and the synthetic graft, thus causing major complications like intima hyperplasia. While the stress-strain-curve in synthetic grafts is linear and the grafts are relatively stiff, native blood vessels are soft and have a non-linear, strain-stiffening mechanical behavior. In our ERC Starting Grant CELLINSPIRED we have developed a material structure that allows us to mimic the strain-stiffening of blood vessels. We will employ our strain-stiffening materials in synthetic vascular grafts with broad applicability in the field of vascular surgery. Within the proposed project VASCUGRAFT we will fabricate demonstrators of such biomimetic vascular grafts and strive to find a company that licenses our invention and brings it on the national and international market.


**Keywords:** Vascular graft, implant, soft material, mechanical compliance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Resolving the Neuropharmacology and Genetics of Zebrafish Sleep' (ZFISHSLEEP) under Seventh Framework.

assistant: **Objectives**

Sleep is a fundamental process, yet the genetic and neural mechanisms that regulate sleep are largely unknown. We have developed the zebrafish as a model system to study the regulation of sleep because it combines the genetics of invertebrates with the basic brain structures that regulate sleep in humans. We previously designed high throughput behavioural assays to measure sleep behaviours in the fish and used genetic tools to demonstrate that the wake-regulating hypocretin/orexin (Hcrt) system is functionally conserved in the zebrafish. We have also used our assays to perform a small molecule screen and identified both conserved and novel candidate regulators of sleep in zebrafish.In Aim 1, we will observe the behaviour of wild type and Hcrt receptor mutants to a panel of small molecules known to alter zebrafish sleep. This aim tests the hypothesis that these compounds exert their effects on sleep and wake through the Hcrt system. In Aim 2, we will follow-up on the compounds that had differential effects in the mutants. We will monitor the activity of Hcrt neurons in response to drugs using a new neuroluminescent technique to observe the activity of neurons in freely behaving zebrafish larvae. This Aim will extend the behavioural data to the level of neural circuits. In Aim 3, we will use new methods to globally observe neuronal activity in the zebrafish brain to extend our analysis to neurons thought to interact with the Hcrt system. By observing activity across the sleep/wake cycle, we may also uncover novel sleep regulating neurons.Overall, this project takes a multidisciplinary approach to the study of sleep and the Hcrt system, leveraging new methods from chemical biology, molecular genetics, and behavioural neuroscience in the zebrafish. As little is known about
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Understanding Deep Face Recognition', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Face recognition is a fascinating domain: no other domain seems to present as much value when analysing casual photos; it is one of the few domains in machine learning in which millions of classes are routinely learned; and the trade-off between subtle inter-identity variations and pronounced intra-identity variations forms a unique challenge. The advent of deep learning has brought machines to what is considered a human level of performance. However, there are many research questions that are left open. At the top most level, we ask two questions: what is unique about faces in comparison to other recognition tasks that also employ deep networks and how can we make the next leap in performance of automatic face recognition? We consider three domains of research. The first is the study of methods that promote effective transfer learning. This is crucial since all state of the art face recognition methods rely on transfer learning. The second domain is the study of the tradeoffs that govern the optimal utilization of the training data and how the properties of the training data affect the optimal network design. The third domain is the post transfer utilization of the learned deep networks, where given the representations of a pair of face images, we seek to compare them in the most accurate way.Throughout this proposal, we put an emphasis on theoretical reasoning. I aim to support the developed methods by a theoretical framework that would both justify their usage as well as provide concrete guidelines for using them. My goal of achieving a leap forward in performance through a level of theoretical analysis that is unparalleled in object recognition, makes our research agenda truly high-risk/ high-gains. I have been in the forefront of face recognition for the last 8 yea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Potable water distribution management' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The aim is to establish the feasibility and efficacy of introducing real-time, optimal-control for water-distribution networks with a view to reducing operating costs and leakage. To that end, a generic methodology will be developed based on the use of a trained artificial neural network for predicting the consequences of control settings and a genetic algorithm to determine the optimal combination. Demand fluctuations, operating constraints and tariff structure will be taken into account. The prototype system will be applied to two networks of different complexities and the results compared with manual control. As a consequence of improved pressure management, it is confidently expected that optimal control will save some 20 percent of operating costs, particularly if leakage reduction is taken into account. Additionally, there will be improvements to system performance by ensuring that operational requirements are consistently met.