RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Electronic the Secure Municipal Administration for European Citizens', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Municipalities are the eGovernment organizations with which citizens interact most frequently in order to request/process certificates, pay city taxes and receive city information. Citizens need to trust their local municipalities and the municipalities are obliged to provide confidence to their citizens that they fulfil their mission in an effective way.Public documents and services impose all security requirements i.e. confidentiality, authentication of data and user, integrity, non repudiation. The replacement of the traditional signature with the digital signature imposes problems when applied cross-border or by a group of citizens with limited IT training and security exposure. The adoption of e/m-services by medium and small size public organisations is difficult, as it requires expertise in technical, organizational as well as legal, political and financial support. Municipalities therefore, have difficulties in making the next step in offering services to the European citizens throughout the European continent.With this proposal we aim to contribute towards the provision of secure and interoperable eGovernment services, by developing an affordable, ease-of use- electronic platform (eMayor platform) hosting secure municipal Web Services. In order for the eMayor platform to be successfully deployed across Europe, on one hand, it will be a simple open solution based on widely accepted standards with good market support. On the other hand, the platform will be Internet based and will enable communication with legacy as well as newly developed systems residing on heterogeneous platforms. Web Services and XML address both sets of requirements and therefore these technologies will form the core for the R&D effort and implementation. eMayor will highly consider the barr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Development of Fluorescent Polypeptide Biosensors for Detection of Protein Kinase Cancer Biomarkers and Drug Discovery Programs'.

assistant: **Objectives**

This proposal is intended to develop biosensors, named CDKACT and CDKCONF, as smart tools to detect and study key cancer biomarkers, such as CDK4 and CDK5 kinases, which may be of potential value for cancer diagnostic and theragnostic purposes, as well as to propose new selective compounds for cancer therapeutics by screening for non-ATP-competitive inhibitors of these targets.This is a multidisciplinary project at the interface between chemistry, biochemistry, biology, and cell and animal imaging technologies. A wide variety of state-of-the-art technologies will be applied, including: (i) innovative chemical approaches for the design, synthesis and engineering of peptide and protein biosensors, (ii) biochemical, biophysical, and fluorescence-based approaches for characterization of the sensitivity, specificity and physicochemical features of the biosensors, (iii) cell biology and fluorescence imaging approaches for characterization and validation of these biosensors in cellulo and in vivo, (iv) application of fluorescent biosensors for development of diagnostic assays, and (v) application of fluorescent biosensors for development of high throughput screening assays and identification of selective non-ATP competitive inhibitors for cancer therapeutics.This program will have a large scientific, technological and economic impact, by providing new diagnostic tools and molecules with selective inhibition profiles with application to life sciences and biomedicine. Expected results will contribute to improve early detection of alterations associated with cancer cell proliferation, and will provide novel kinase inhibitors for cancer therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Fediversity' (Fediversity) under Horizon Europe.

assistant: **Objectives**

Open internet discourse is part of the future of open collaboration and open discussion, forming a federated safe space for what used to be called social networking. The Fediverse, funded by the NGI program as an implementation of such a federated space, is already taking shape and approaching ten million users. It has special safeguards for marginalized and oppressed groups in our global society. This NGI technology is mature enough to be joined by older institutions and organizations, many tech-savvy media outlets and public institutions have already joined [^adoption]. But for wider adoption the Fediverse needs to be supported by dedicated and knowledgeable support organisations, for which this project will lay the groundwork in the form of reproducible deployment configurations, how-to documents, cookbooks, playbooks and descriptions of success stories. Not only will we create a complete script for support organisations that want to _host_ Fediverse services and other open discussion tools on how to deploy them on their infrastructure, we will also onboard several public organisations that want to _use_ these services to show-case, and to gain and document experience on do's and don'ts. After all, public communication infrastructure, even though very practical, isn't easy to do and this project is accordingly about creating a simple to use, very practical and safe environment to communicate, assembling various powerful components that NGI and others have built into unified end-to-end services. This is where we can make a difference, especially in contrast to existing centralized solutions owned by Big Tech.


**Keywords:** Fediverse Federation Social Networking
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Aerodynamic loads estimation at extremes of the flight envelope' under Seventh Framework.

assistant: **Concept**

ALEF's objective is to enable the European aeronautical industry to create complete aerodynamic models of their aircraft based on numerical simulation approaches within the respective development processes. I.e. ALEF will kick-off a paradigm shift from greater confidence in experimentally measured loads data to greater confidence in computational results. Beyond the scope of ALEF this paradigm shift will essentially influence the overall aerodynamic development process. The objective has three aspects:  1. Comprehensiveness refers to the ability to predict aerodynamic forces, moments and their derivatives in time for any point of the flight regime. It is addressed by two complementary approaches: A high fidelity CFD based approach serves short-term impact. Long-term improvements are delivered by incorporation of simulation tools of different fidelity. 2. Quality refers to the accuracy and physical correctness of each flow simulation result used for aero data prediction as well as to a high coherence of aero data integrated over the complete flight envelope from tools of varying fidelity. It is improved by considering the impact of physical modelling as well as novel quality control means to achieve a highly coherent data space representation. 3. Efficiency refers to the necessity to compute the entire aero data space within time frames dictated by industrial design processes at given costs. It is tackled by means of surrogate models for both steady and unsteady flows. Also planning techniques for efficient simulation campaigns are addressed. The ultimate scope of using simulation tools in aero data generation is to cover all flight conditions and configurations by means of a numerical toolbox. This would ensure an up-to-date and fast estimation of most recent statuses o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Living with landslide risk in Europe: Assessment, effects of global change, and risk management strategies' (SAFELAND).

assistant: **Innovation**

SafeLand will develop generic quantitative risk assessment and management tools and strategies for landslides at local, regional, European and societal scales and establish the baseline for the risk associated with landslides in Europe, to improve our ability to forecast landslide hazard and detect hazard and risk zones. The scientific work packages in SafeLand are organised in five Areas:  Area 1 focuses on improving the knowledge on triggering mechanisms, processes and thresholds, including climate-related and anthropogenic triggers, and on run-out models in landslide hazard assessment; Area 2 does an harmonisation of quantitative risk assessment methodologies for different spatial scales, looking into uncertainties, vulnerability, landslide susceptibility, landslide frequency, and identifying hotspots in Europe with higher landslide hazard and risk; Area 3 focuses on future climate change scenarios and changes in demography and infrastructure, resulting in the evolution of hazard and risk in Europe at selected hotspots; Area 4 addresses the technical and practical issues related to monitoring and early warning for landslides, and identifies the best technologies available both in the context of hazard assessment and in the context of design of early warning systems; Area 5 provides a toolbox of risk mitigation strategies and guidelines for choosing the most appropriate risk management strategy. Maintaining the database of case studies, dissemination of the project results, and project management and coordination are defined in work packages 6, 7 and 8.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Wnt/calcium signaling in cardiovascular development' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

While much is known about genetically encoded developmental pathways, the mechanisms by which the electrochemical cues interact with traditional morphogenetic pathways during embryogenesis are poorly understood. The central idea of the proposed research is to understand the interplay between major signaling pathway and electrochemical cues during embryogenesis as well as in disease. We have developed technologies to explore the role of electrochemical and other physiologic stimuli during development in the zebrafish. We have demonstrated that Wnt11 non-canonical signaling, a major developmental pathway regulating tissue morphogenesis and organ formation, patterns intercellular electrical coupling in the myocardial epithelium through effects on transmembrane Ca2+ conductance mediated via the L-type Ca2+ channel. The specific aims of the proposed research focus on determining the fundamental molecular mechanisms that lead to the attenuation of L-type Ca2+ channel function by non-canonical Wnt signals, on characterizing how non-canonical Wnt signals compartmentalize and affect different Ca2+ domains in excitable as well as non-excitable tissues and on determining how electrochemical signals modulated by Wnt11 regulate cardiac morphogenesis and cardiac function. The finding that Wnt non-canonical signaling modulates the transmebrane conductance of the L-type Ca2+ channel represents a novel limb of Wnt/Ca2+ signaling. Furthermore, it establishes a role for a major developmental pathway in the integration of intracellular and extracellular ion fluxes, and thus provides a new paradigm for studying the interplay between development and physiology, and for understanding how function and form interact not only during embryogenesis, but also during disease state.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dynamical systems modeling of neural activity in the somatosensory system' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The project targets the development of a model of the internal representation of neural activity in the somatosensory system. The model must explain the signal processing and the rhythmic interactions performed by different cell groups. The project comprises the analysis of experimental data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Total Syntheses of Catharanthine and Keramaphidin B by an Iridium-Catalyzed Reductive Cyclization Cascade' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

During the course of this Fellowship a reductive cyclization cascade for dihydropyridinones, which consists of an iridium-catalyzed reduction to the corresponding electron-rich dienes and subsequent [4+2] cycloaddition (Diels-Alder reaction) will be developed. A first promising proof of concept study establishing the feasibility of this powerful transformation has already been carried out in the Dixon group; however further optimization by varying the solvent, the reaction time, the temperature or by using suitable Lewis acids is required to perfect the methodology. The additional use of chiral Lewis acid or chiral amine catalysts is also intended to develop an enantioselective variant of this method. The methodology development should then be completed by determining the substrate scope. The resulting azabicyclo[2.2.2]octene motif is an important structural component of various alkaloids. Therefore, this reaction cascade should then be used as a late stage key step in the total syntheses of the natural products catharanthine and keramaphidin B.Catharanthine is an important member of the large class of iboga alkaloids, which usually carry as common structural feature an indole or an indoline moiety. Catharanthine can be considered as a direct precursor of the dimeric Catharanthus alkaloids vinblastine and vincristine, both of which are clinically valuable agents in the treatment of cancer due to their ability to inhibit mitosis the formation of microtubules.The marine alkaloid keramaphidin B belongs to the manzamine family and shows cytotoxicity against P388 leukaemia cells in mice (IC50 0.28 μg/mL) and against epidermal KB cancer cells in humans (IC50 0.30 μg/mL). Structurally, keramaphidin B is a pentacyclic compound comprising two piperidine rings (one bridged and on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Intelligent Advanced Photonics Tools for Remote and/or on-site Monitoring of Cultural Heritage Monuments and Artefacts' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

iPhotoCult aims to design, develop, demonstrate, and validate innovative and intelligent solutions that will allow for non-invasive and safe ways to inspect, document, diagnose, and monitor Cultural Heritage (CH) so as to ensure efficient adaptation of sustainable management plans. These solutions comprise (a) a unique suite of advanced diagnostic and monitoring tools along with methodologies for their effective and optimum use, combined with (b) an intelligent data processing, visualization and prediction software services platform, for the remote and/or on-site monitoring of CH buildings, monuments and artefacts impacted by a wide variety of environmental and anthropogenic threats. iPhotoCult contributes significantly to the preservation of CH by adding verifiable dimensions to preservation strategies. The iPhotoCult Solutions will enable and empower CH community to better assess CH in a cost-effective, efficient, reliable, user-friendly and safe manner. These solutions will revolutionize the capabilities of end-users to diagnose and continually monitor the condition of materials constituting CH including those used in their restoration.  iPhotoCult interdisciplinary approach involving many different stakeholders and CH pilots across Europe will serve as use-cases for demonstration, testing and validation of the iPhotoCult Solutions delivered and applied in the form of demonstrators. The outcomes to a variety of CH pilots will provide crucial insights and enable the optimization of the tools and methodologies to help in the decision-making and serve for replication to Europe’s CH in many in real settings.Ultimately, iPhotoCult main goal is to contribute to the sustainable management of Europe's CH by leveraging advanced photonics technologies and intelligent software
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Radically innovative bacterial treatment for recalcitrant industrial wastewater' (RIBATI) targeting Horizon 2020.

assistant: **Abstract**

Manufacturing industries are responsible for large loads of contaminants discharged in water. As each wastewater has different composition, each of them requires specific treatment in order to remove the contaminants. Treatments are expensive (€40-121,4/m3) and usually their efficiency is low – as little as 20% in some sectors. Moreover, EU environmental regulations are becoming stricter. These facts are putting the industry at serious risk: factories may be forced to closure because of the high costs and the non-compliance with regulations, which involves heavy sanctions. Amapex has developed RIBATI, an integral industrial wastewater treatment service based on 3 key elements: i) Active Product, composed by a blend of a specific registered bacterial strain and a selected variety of 12 oligoelements; ii) Smart Doser Unit, an exclusive automatic device that adjusts dose, time, temperature and life cycle of the active product, and iii) an integral service including a landing study, installation, maintenance, supply of active product and recurrent analysis of treated wastewaters. Our invention has been tested with more than 30 potential clients with promising results: leading up to 59% savings and allowing for water reuse in some water-intensive industries like the textile sector. Our solution is adapted to the industry’s needs and it also adapts to the needs of every individual client. Our revenue model will be based on subscriptions, what we call RIBATI PAY PER FLOW. Our target are SMEs from the textile, tanning, metals processing, chemical and car wash sectors, which represent 30% of the EU manufacturing sector (around € 1,85 bn in Europe). Our target countries are Spain, Italy, France, Belgium, Netherlands and Germany. By year 5, we expect to treat about 500.000 m3 of w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sustainable prevention of obesity through integrated strategies' (SPOTLIGHT).

assistant: **Innovation**

BACKGROUNDThe prevalence of overweight and obesity in Europe is high and contribute to mortality and the burden of many chronic diseases, especially within groups of lower social-economic status. Obesity is largely determined by modifiable lifestyle dependent risk factors such as reduced physical activity, sedentary behaviour and an unhealthy diet. There is growing evidence that influences on individuals and their lifestyle should not only be addressed in single-level interventions that focus on a distinct individual, social or environmental aspect, but rather in community based multi-level intervention approaches (MIAs) that integrate individual, community, organisational, and societal systems.OBJECTIVESSPOTLIGHT aims to increase and combine knowledge on the wide range of determinants of obesity in a systematic way, and to identify MIAs that are strong in terms of Reach, Efficacy, Adoption, Implementation and Maintenance (RE-AIM). A further aim is to identify factors for successful implementation of MIAs into health promotion practice.APPROACHBy combining published research and collected cross-European data with expert and target-group perspectives, effective, sustainable and implementable MIAs that counteract obesogenic behaviours in adults will be defined.ACHIEVEMENTSWe will provide an evidence-based model for effective MIAs in health promotion practice applicable across Europe, and disseminate our findings by policy makers and the scientific community. We will develop a handbook with evidence- and practice-based instructions as well as practical recommendations for policies and interventions, suggestions and reference to best practice that serve as a major dissemination tool.IMPACTThrough systematic dissemination of SPOTLIGHT outcomes, the project supports the devel