RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Beating Heart'.

assistant: **Innovation**

Intravital microscopy (IVM) methods are enjoying an ever broader acceptance as they can be used to gain insight into cell biology in vivo. Unfortunately, most set-ups use window chambers (e.g. cancer) or isolated organs, all highly artificial model systems which are often not compatible with survival imaging. Because of these caveats, imaging in orthotopic locations is always preferable and can theoretically be achieved via motion compensation and tissue stabilization techniques. Recently, different approaches have been proposed including the use of suctioning devices for lung imaging. Unfortunately these approaches are not very effective in achieving stabilization. Moreover many of them induce severe damage to the myocardium. In this proposal we intend to develop a in-vivo real-time intravital microscopy imaging system for imaging moving organs (specifically the beating heart) at the sub-cellular resolution level, capable of compensating all motion artifacts inevitably present in in-vivo models. Our approach will use a combination of rigid motion stabilization through the design of novel stabilizers and sophisticated algorithms for acquisition during advanced cardiopulmonary gating. This system will allow for the first time to study in vivo the biology and physiology in the beating heart. This is at present a totally unexplored field due to the current lack of availability of any imaging technique. Results will be potentially exciting and innovative and will open a new paradigm in the understanding of the physiological properties of the heart and immune system responses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Hippocampus unites Memory Systems by preserving Sequential Order' (MemUnited), addressing dissemination and exploitation.

assistant: **Impact**

It is generally assumed that there are two distinct memory systems in the human brain:  declarative memory supports memories for facts and events, while the procedural memory supports motor skills. However, recent evidence suggests that these multiple memory systems are less independent than originally thought and that the hippocampus, historically associated with declarative memory, is also involved in procedural motor memory. Accordingly, the project MemUnited (Hippocampus unites Memory Systems by preserving Sequential Order) proposes and tests an integrative framework that specifies the shared neural processes that support learning and memory across multiple memory systems. Specifically, given that declarative episodic and procedural motor memories consist of temporally organized sequences of events (e.g. order in which guests arrived at your dinner party) and movements (e.g. playing the piano), and the hippocampus is critical to preserve sequential order of experiences, I will investigate whether the neural mechanisms of sequential order processing supported by the hippocampus are jointly used in declarative episodic and procedural motor memory. To do so I will use state-of-the-art multivariate pattern analyses of functional Magnetic Resonance Imaging data acquired during the different phases of memory formation (i.e., encoding, consolidation and retrieval). Findings in the proposed research will fill a gap in the field by providing a detailed characterization of the role of the hippocampus in multiple memory systems. The findings will offer the opportunity to reconsider the historical models of memory classification and develop more integrative views of memory organization in general and hippocampal functioning in particular. Moreover, it will open new avenues for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Role of the Keap1/Nrf2 antioxidant response system in thyroid gland homeostasis and thyroid cancer' (THYROIDANTIOXIDANT) targeting Seventh Framework.

assistant: **Abstract**

Recently, it has been discovered that the thyroid gland has increased ability to withstand oxidative stress compared to other organs. This important feature allows the gland to maintain its homeostasis in the face of increased burden of free radicals produced during iodine metabolism for thyroid hormone synthesis. Iodine deficiency and goiter are associated with increased oxidative stress in the thyroid. While some antioxidant enzymes are known to be upregulated in the thyroid under such conditions, the broader regulatory mechanisms of oxidative stress resistance remain unknown. The proposed research aims to investigate the role of the major antioxidant response system orchestrated by the transcription factor Nrf2 in thyroid gland homeostasis and thyroid cancer. Specifically, it will examine whether Nrf2 regulates the thyroid’s antioxidant defenses; whether Nrf2 activity in the thyroid is altered during iodine deficiency and goitrogenesis; and whether constitutive Nrf2 activation by somatic mutations is associated with thyroid cancer. These investigations will utilize mouse knockouts of Nrf2 and wild-type animals, primary thyroid cell cultures derived from these mice, and archived thyroid cancer samples from human subjects. This work has implications for the management of iodine deficiency and the prevention of thyroid carcinogenesis. This interdisciplinary research project will be executed by Dr. Gerasimos Sykiotis, a translational investigator who has prior research experience in thyroid gland pathophysiology and has acquired state-of-the-art expertise with the Nrf2 antioxidant response system in the country of origin (USA). The University of Patras Medical Center is a highly qualified host organization as it has in place both the nrf2-/- animals and the human thyroid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Micro-scale optofludics control based on thermoplasmonic effect of nanoparticle arrays'.

assistant: **Concept**

Optofluidic control is emerging as a promising tool in wide applications like pharmaceutics, chemistry, energy, and biology, due to the development of micro-fluidic chip. The control unit usually requires complex optical set-ups or special materials for working fluid or micro-channel. The aim of the present project is to develop a light controlled microvalve technique that can be utilized to manipulate fluid flow in micro-channels and potentially promote the development of new generation of light driven micropump or micromotor.  Numerical model and experimental setup will be established to investigate nanoscale photothermal conversion and temperature manipulation involved in the plasmon-assisted optofluidics. Duo to wide applications of microfluidic devices, this unique project will not only be helpful for European biomedicine industry, including R&D of new drugs, but will also promote fundamental research level in related areas, such as microfluidic control and thermoplasmonics.The project is carefully designed to match the fellow's expertise in thermoplasmonics and the expertise of the host institute in micro-flow and heat & mass transfer. The overall aim of the project is to develop a light controlled microvalve technique that can be utilized to manipulate fluid flow in micro-channels. Meanwhile, the research fellow will contribute his expertise on thermoplasmonics and photothermal conversion, and will provide important training to EU researchers, industrial contacts and undergraduates by: hosting a series of seminars, giving a special lecture on thermoplasmonics for undergraduate students, and participating in outreach activities of the university. The researcher has 5 years’ experience on experimental and numerical studies for nanoscale thermoplasmonics. Combining
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Developmental expression and function of survival factors and their receptors in the schwann cell lineage'.

assistant: **Concept**

My pilot studies suggest that (I) Schwann cells undergo programmed cell death in vitro when cultured at low cell density; (II) that this has not been noticed previously because Schwann cells secrete autocrine survival factor(s) that prevent their death in routine medium / high density cultures, and (III) that neuregulins and neurotrophins might support Schwann cell survival. In this project I plan to confirm, analyse and extend these observations. Firstly, the mechanisms of cell death will be further studied using in situ hybridization and ultrastructural studies, and the death will be quantified with respect to cell density, time in vitro and type of culture substrate. Secondly, growth factors will be screened for their ability to block Schwann cell death, with particular emphasis on neuregulins and neurotrophins. Thirdly, I will aim to identify the autocrine survival promoting activity present in Schwann cell conditioned medium using blocking antibodies and ligand trap methods. Fourthly, the developmental expression of relevant receptors and their regulation will be investigated. Lastly, if time allows I will seek to interfere with the expression of functional receptors by overexpression of dominant negative mutations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Robotics Technology for Inspection of Ships' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The ROBINS project aims at filling the technology and regulatory gaps that today still represent a barrier to the adoption of Robotics and Autonomous Systems (RAS) in activities related to inspection of ships, understanding end user’s actual needs and expectations and analyzing how existing or near-future technology can meet them.ROBINS aims to improve the ability of RAS in sensing and probing, in navigation and positioning in confined spaces, as well as the capability to access and move safely within hazardous spaces.ROBINS also aims to provide new software tools for image and data processing, e.g. for production of 3D models and virtual/augmented reality environments, to provide the surveyor with the same level of information as obtained by direct human observation.A framework for the assessment of equivalence between the outcomes of RAS-assisted inspections and traditional procedures will also be provided by defining test procedures, criteria and metrics for the evaluation of RAS performance. Test campaigns will be performed both on-board and in a specific testing facility, where repeatable tests and measurements can be carried out.The development of robust technical solutions and a regulatory framework for RAS-assisted ship inspection is expected to streamline wide scale adoption of RAS technology in marine industry. The impact on safety, as far as hazardous environments are involved, can be easily understood and has already been witnessed in similar industrial domains (energy, oil and gas). The economic impact is expected to be beneficial for robotics industry (new supply chains and new potential markets), ICT industry (new services and products for data processing specific to marine industry), ship asset owners and operators (reduction of costs due to simplified p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Hyper-Kamiokande Outer Detector' (Hyper-KOD) under Horizon 2020.

assistant: **Objectives**

This project aims to increase the mass ordering sensitivity of the future world’s largest water-Cerenkov neutrino detector Hyper-Kamiokande (Hyper-K), which is still unknown and one of the major questions in physics. I would be working on the on-going Super-Kamiokande (Super-K) atmospheric neutrino analysis, and transfer this newly acquired experience to improve the design of Hyper-K. I will focus on the Outer-Detector (OD) system, consisting of photosensors (PMTs) mounted behind the Inner Detector (ID) PMTs and facing outwards to view the outer shell of the cylindrical tank, to boost the event classification power based on their topology and improve the overall energy scale calibration to the mass ordering analysis.The project is divided into two parts which would take place in parallel: Firstly, I would work at the University of Tokyo (IPMU) with the Super-K collaboration on their atmospheric neutrino data, to improve the sample selection using the OD hits information. I would perform the first joint fit between beam and accelerator neutrinos to update and increase the significance of our knowledge of the mass ordering. At the same time I would use their neutrino laboratory to set the Quality Assurance of the OD PMTs during the incoming construction phase of Hyper-K. Working at the same time on the Super-K analysis would provide direct information for the Hyper-K OD design, to enhance the mass ordering sensitivity. In the second phase of this action I would work at King's College of London (KCL) where I will perform these sensitivity studies and train the UK groups members during the OD assembly.  As I am already the OD working group convener, my strong hardware, software, and analysis skills would put me in the best position to lead this project. This new collaborati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ASESSMENT AND INITIAL STEPS FOR THE EXPLOITATION OF A SIMULATION SOFTWARE FOR THE STUDY AND MITIGATION OF THE EFFECT OF FLOODS ON CONSTRUCTIONS AND LANDSCAPE' (FLOODSAFE).

assistant: **Concept**

In the FLOODSAFE PoC we will explore the industrial applicability and potential for commercialization of the computational technology developed in the SAFECON Advanced Grant project for the study and mitigation of the effect of floods on constructions and landscape. The SAFECON technology will help engineers to the enhanced design, building and maintenance of new protective constructions under extreme floods, as well as for the surveillance, risk management and monitoring of existing constructions and landscape in flooding situations. The FLOODSAFE PoC will greatly help move the SAFECON software technology towards the initial steps of an innovation process leading to a new software for study of particulate mudflows and their interaction with constructions and landscape with the ultimate aim of ensuring the safety of existing and new civil infrastructures and the environment during floods.In FLOODSAFE we will test the SAFECON software for solving practical cases of the effect of floods on constructions and landscape, define end user requirements, identify market needs, select potential users and define the roadmap for transfer and commercial exploitation of the software.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'MEMS Tuneable Metamaterials for Smart Wireless Applications' (TUMESA).

assistant: **Concept**

The proposed project focuses on development of tuneable metamaterials and metasurfaces based on microelectromechanical systems (MEMS) and their integration to smart wireless systems such as radar, secure high-capacity communication systems, radio astronomy, atmospheric remote sensing, spectroscopy, etc. MEMS allow miniaturisation of electronic components, reduce their cost in batch production and effectively compete with semiconductor and ferroelectric based technologies in terms of losses at millimetre wavelengths. Metamaterials provide a way to design devices with unique and engineered electromagnetic properties. The advantage of convergence between MEMS and metamaterials is ability to create novel miniaturized reconfigurable low-loss and cost-effective wireless devices with innovative self-adapting mechanisms.In addition to industrial and technological objectives, a number of socio-economic challenges urge research in smart wireless applications. EU authorities have launched a program to reduce fatal road accidents by 50% by 2010, with the focus on driver assistance and on-board safety systems for accident reduction, including automotive radar. For this purpose, the European Telecommunication Standard Institute ETSI has already produced a standard for automotive radar in the 79 GHz range.The main objectives of the proposed project are: to develop novel on-chip phase shifting and beam-steering devices based on MEMS tuneable high-impedance surfaces; to integrate developed phase shifting components in novel space-efficient antenna arrays on a single chip; to elaborate novel concepts of implementation the beam-steering devices and antenna arrays in cost-efficient radar sensor and future high-capacity wireless communication systems and evaluate fabricated prototypes at a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'PROBING EXOTIC QUANTUM HALL STATES WITH HEAT QUANTUM TRANSPORT'.

assistant: **Objectives**

Under high magnetic field and at low temperatures, electronic interactions in a two-dimensional electron gas give rise to exotic, strongly correlated many-body quantum Hall states. These states have been proposed for the implementation of new quantum circuits, for instance realizing topologically protected quantum computing. Although exciting, these states remain poorly understood, because the conventional experimental approach for their investigation, dc electron transport, only yields limited information. In particular, electron transport only probes the physics of the current-carrying edge channels of the quantum Hall effect propagating along the edges of the electron gas, leaving the physics of the bulk unexplored. To gain a better understanding of these exotic states and their origin, I propose a new, unconventional approach, based on heat transport measurements, which directly probes the charge-neutral, heat-carrying collective modes characterizing these interactions-induced states. I will focus on the debated ν=0 quantum Hall state of monolayer and bilayer graphene, which is thought to arise from spontaneous spin- and valley- symmetry breakings due to interactions, and on the fractional quantum Hall effect, where the competition between interaction and disorder gives rise to low-energy, heat-carrying neutral modes which have not yet been observed in graphene. Investigating the neutral modes through heat transport will address two important questions regarding these exotic new states: does ν=0 indeed arise from spontaneous symmetry breakings, and what is the origin of the low-energy neutral modes in the fractional quantum Hall effect, particularly in graphene. Furthermore, it will be possible to apply my approach to the investigation of other exotic quantum states
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'An assessment of bio-oil toxicity for safe handling and transportation - target action H' (BIOTOX), addressing dissemination and exploitation.

assistant: **Impact**

The aims of the project are:-to produce fast pyrolysis bio-oils with low impact on human health and environment by optimising the production process of bio-oils-to determine toxicological, eco-toxicological and biodegradable data on bio-oils.This will allow a complete MSDS to be defined with the proper preventive and remedial procedures to adopt during production, transport and use of bio-oils.-to determine the process parameters allowing to reduce oil toxicity and improve biodegradability-to establish a database on toxicology and environmental impacts of bio-oils for information dissemination and improved awareness of industrialists.