RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'RNA virus attenuation by altering mutational robustness' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

RNA viruses have extreme mutation frequencies. When a RNA virus replicates, nucleotide mutations are generated resulting in a population of variants. This genetic diversity creates a cloud of mutations that are potentially beneficial to viral survival, but the majority of mutations are detrimental to the virus. By increasing the mutation rate of a RNA virus, viral fitness is reduced because it generates more errors, and attenuates the virus during in vivo infection. Another feature that affects RNA virus fitness is mutational robustness. Mutational robustness is the ability to buffer the negative effects of mutation.    The attenuation of RNA viruses for vaccine production faces problems of genetic instability and reversion to a pathogenic phenotype. The conventional method for attenuation is mostly empirical and specific to the particular RNA virus species. Hence, it cannot be universally applied to a variety of virus types. We've developed a non-empirical, rational means of attenuating RNA viruses, targeting mutational robustness as modifiable trait.     We demonstrate that mutational robustness of RNA viruses can be modified without changing a virus' physical and biological properties for vaccine production; yet the virus is attenuated as it becomes victim of its naturally high mutation rate. Specifically, the genome of RNA viruses are modified so that a larger proportion of  mutations become lethal Stop mutations. Our technology places the virus one step away from these Stop mutations (1-to-Stop). We succeeded in attenuating two RNA viruses from very different viral families, confirming the broad applicability of this approach. These viruses were attenuated in vivo, generated high levels of neutralizing antibody and protected mice from lethal challenge infection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Quantum Bits in Carbon Nanostructures' (CARBONQUBITS), addressing dissemination and exploitation.

assistant: **Impact**

Quantum computation (QC) is expected to improve the efficiency of certain computational tasks. QC schemes are formulated in terms of operations on quantum bits (qubits), whose values are superpositions of two quantum states. A natural candidate for the physical implementation of a qubit is the spin of an electron. In fact, breakthrough experiments recently demonstrated the ability to initialize, manipulate, couple and read out spin-based qubits using electrons confined in a solid state environment. New perspectives have been opened in solid-state QC by recent proposals exploiting the peculiar characteristics of carbon nanotubes (CNTs): utilizing electronic states circulating around the CNT circumference in qubit implementation is promising for various reasons. To evaluate the potential in these novel qubit realizations, we plan to develop a profound theoretical understanding of the physical mechanisms allowing initialization and readout of the qubit, causing two-qubit interactions, as well as those leading to the loss of information encoded in the qubit. We expect that our results will enable the design of carbon nanostructures optimized for QC,  provide understanding of related recent and future experiments, and highlight fundamental new quantum-physical phenomena on the nanoscale.The completion of the project requires tools of condensed matter theory (tight-binding and envelope-function models, theories of hyperfine, spin-orbit, exchange and electron-phonon interactions), and the theory of non-equilibrium quantum systems (quantum master equation).The EU contribution would enable the applicant to establish himself in Hungary after his mobility period, contribute significantly to the scientific success of his research career, improve considerably the prospects of his pe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Laser welding of newly developed Al-Li alloy' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The proposed LAWENDEL project aims to develop laser welding process for aerospace applications by combining expertise in model based process design at the University of Manchester with a systematic experimental approach by the project coordinator, Helmholtz-Zentrum Geesthacht. The objective is to study the laser weldability of a newly developed Al-Li alloy, to determine the process parameters needed to obtain consistent laser welds, and to compare the mechanical behaviour with the conventional aluminium alloys series. The study will emphasize the microstructure characteristics and the mechanical properties of the weld joint to gain an understanding of the underlying factors controlling the performance of the welds. During the demonstration phase of the project, the developed LBW technology will be applied for welding a stiffened flat panel out of the new Al-Li alloy, named demonstrator B1, in order to evaluate the industrial application. The skin and the stiffener will be provided by Topic Manager. The demonstrator B1 is a rectangular aluminium panel 384 mm x 742 mm (AA2198) with 4 stringers out of AA2196 spaced in equal distances. Three demonstrator panels will be welded by using the optimized parameters defined from the previous phase and then inspected by NDT in order to assure the structural integrity. The innovative combination of state of the art modelling and experiments will enable physics based optimization of the welding process with greatly reduced time and cost compared to traditional trial and error methods.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Efficient system to enable storage of high temperature solar heat energy' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Heating and cooling account for 49% of world energy demand, this requires significant fuel sources to satisfy demand and attention has now become focussed on renewable sources such as wind, wave and solar. Currently there are problems associated with using solar heat for industrial processes. Chief among these is that the availability of heat is not synchronised with the demand for it, with the additional complication that solar availability undergoes natural fluctuations according to weather patterns. Until now there have been no technologies capable of storing heat at a temperature level that will be useful in an industrial setting, 100-200°C. Therefore we believe it is essential that a new method of heat storage technology is developed. This proposal contains details of the approach we will take to develop an automated system capable of storing solar heat, and heat recovered from processes, for use when required. Using novel materials for the reactor and a thermochemical process involving reaction pairs to provide the heat storage, we will develop and optimise a system that will be appropriate for use in industrial applications where heat between 100 to 200°C is required. The system, comprising a Fresnel concentrator, reactor, storage vessels and process control equipment, will be constructed in as simple format as possible to ensure that it can be easily installed and maintained at the site where heat is needed. With over 310,000 companies involved in the food and drink sector in Europe, 99.1% of these being SMEs, we have selected this as our primary target market. Energy use in this sector is high due to processes requiring steam or hot water such as cooking, evaporation, sterilisation, drying, space heating and baking. However, other sectors such as abattoirs, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Marine microalgae immunostimulant complex to boost the competitiveness of the EU aquaculture sector'.

assistant: **Objectives**

The EU aquaculture sector is of high importance for the EU economy. However, EU aquaculture producers lag behind theglobal competitors that offer cheap products of much lower production costs and quality standards. In order to support EUproducers in this highly competitive market, it is crucial to address their production inefficiencies: 20% mortality rates andlong growth periods. The current solutions, namely use of antibiotics for mortality reduction and aquafeed with incorporatedfishmeal and fish oil for improved growth, are inefficient, costly and extremely unsustainable. Consequently, there is a highneed in the EU aquaculture sector for alternatives that can improve production efficiency in a sustainable, environmentallyfriendlyand antibiotic-free manner.In this context, and basing on the excellent properties of marine microalgae, we have developed ALGABOOSTER -advanced aquafeed enriched with marine microalgae immunostimulant complex to boost fish immune system and growth aswell as buffer the effects of stress, all in a natural way.The Unique Selling Points of ALGABOOSTER are:(i) whole-cell microalgae complex of high purity biomass of three marine microalgae species,(ii) perfectly-preserved microalgae ingredient ensuring thanks to a novel microencausulation process ensuring premium quality product,(iii) safe in use as the functional ingredient is incorporated into aquafeed (no risk of overdose),(iv) 100% non-animal and sustainably sourced (no fishmeal, no fish oil),(v) adjusted to support normal feed in two growth stages Our product has been scientifically tested and guarantees significant reduction in mortality rates and growth cycle durationas well as a substantial increase in quality of the final product. Via ALGABOOSTER´s administration, the productionefficienc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Functional Optoacoustic Neuro-Tomography'.

assistant: **Concept**

The currently available neuroimaging tools, such as functional magnetic resonance imaging (fMRI) and optical microscopy, are not adequate for deep tissue volumetric visualization of brain activity in real time. The need for such solutions underlies the large scale multi-year European Human Brain Project as well as the BRAIN initiative promoted by the US government. Under the currently funded ERC-StG project, we have pioneered the so-called five-dimensional optoacoustic imaging method that can simultaneously render spectrally and temporally resolved volumetric images deep from highly scattering tissues. Taking this achievement one step further, in this PoC grant we propose to prototype and validate a functional optoacoustic neuro-tomography (FONT) scanner specifically tailored for fully noninvasive volumetric observations of activity in whole brains of rodents. In combination with optoacoustics' well-established capacity for resolving vascular anatomy and multiple hemodynamic parameters deep in scattering tissues, this solution will open new vistas in the study of brain activity and development of novel therapies targeting neurological and neuropsychiatric disorders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'European catchments, catchments changes and their impact on the coast (EUROCAT)'.

assistant: **Concept**

In this project we will develop a quantifiable framework of analysis for improved planning and management of catchments by analysing the response of the coastal sea to changes in fluxes of nutrients and contaminants from the catchments. These changes in fluxes are caused by the implementation of regulations, management schemes and by socio-econornic changes. In addition the rate of change is modified by the biogeochemical and physical properties of the catchments. To elucidate these various factors, six regional catchments studies will be carried out using a common framework of analysis (DPSIR). To link the socio-economic drivers in the catchments to the coastal response, the concept of critical loads will be extended to the coast-coast continuum.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A USER DEFINED VALIDATION OF THE IMOS TECHNOLOGY' (ULTIMOS) under Fourth Framework.

assistant: **Objectives**

The present project aims at the industrial validation of the IMOS technology. Specifically, the project has as its goal the development of a demonstration instrument for laser applications. The new instrument will be the first generic example of a new classification of active intelligent" optical devices and addresses the need for versatile opto-electronic micro-systems."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LOng Range ENtanglement between charged levitated particles' (LOREN).

assistant: **Concept**

The quantum entanglement (QE) of macroscopic mechanical oscillators is a unique resource to examine fundamental principles of quantum mechanics at the interface with classical physics.The emerging field of quantum optomechanics is meant to be a benchmark to study quantum phenomena on a macroscale. This Project is aimed to generate and study QE between center-of-mass motion of 2 macroscopic mechanical oscillators –optically levitated particles – a cutting-edge experimental platform offering outstanding control over particles motion, potential landscape and reservoirs. Importantly both particles will be charged to generate long range QE via Coulomb interaction.This study of electromagnetically induced QE is essential to examine consistency of macroscopic systems to basic principles of quantum mechanics. Going in complete parallel to a linear theory of quantum gravity it facilitates our understanding of quantization and vacuum fluctuations of a gravitational field and paves the way for quantum gravitational table-top experiments. The physical system under investigation is a general testbed for experiments at the interface of thermodynamics, information theory & quantum physics, with applications in quantum information technologies, sensing & metrology. This study is timely and highly relevant to the current EU research trends, it goes in line with prioritised research directions of H2020-EU123 programme following 2 out of 5 selected areas: Quantum metrology & sensing and Fundamental quantum science.This Project will be implemented in the group of Prof Aspelmeyer who are leading experts in quantum optomechanics. My background in light-matter interaction and open quantum systems perfectly fits the host group expertise in quantum control and their state-of-the-art facilities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Food identities: biomolecular archaeology reveals multiple and dynamic social identities' (FoodID) under Horizon Europe.

assistant: **Objectives**

The major challenge of archaeological identity studies stems from the dynamic, multidimensional, performative and contextual nature of identities, which are hard to grasp through the material remains alone. To tackle the complexities of different identity manifestations, one possible solution is to investigate the social phenomena that bridge both daily and special events, apply to all members of a community, cover different social categories, and are not limited to material culture. One of these is FOOD!Building on the concept of social foodways, FoodID sets out to reveal how ancient dietary practices reflect individual and group identities through combining cutting-edge biomolecular dietary analysis with an in-depth socio-archaeological contextualisation. This methodological conceptualisation will be applied to eastern Baltic protohistory (1000-1400AD; EBP), serving as a socio-cultural melting pot of multidimensional identity dynamics, due to its diverse foreign contacts, intensified social stratification, different religions and political power-plays. By the systematic integration of well-developed and novel biomolecular methods, applied to human skeletal remains and pottery food residues, the project will reveal a) unique high-resolution individual dietary portraits, and b) intersectional social dietary profiles reflecting multiple and dynamic identity manifestations in different EBP contexts. Furthermore, the diachronic and synchronic inter- and intrasite comparisons will help to reveal the contextual and situational nature identity negotiations. FoodID will validate dietary practices as socially embedded and actively embodied performative phenomena that invigorate multidimensional and dynamic, individual and group identities in past societies. The project will adv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovative Nucleic Acids Technologies for Analysis, Detection and Treatment' under Horizon Europe.

assistant: **Concept**

In recent years, nucleic acids (NAs) have contributed significantly to advancing the diagnosis and treatment of diseases such as cancer, infectious and rare diseases. Breakthrough technologies like genome editing tool CRISPR/Cas9, direct RNA sequencing, multi-omics analysis procedure for NAs analysis, bioinformatics and machine learning for data analysis, and targeted delivery systems based on lipid nanoparticles (LNPs) prove the increasing interest in NAs applicability. However, the full potential of NAs is yet to be unlocked, and the translation of NAs into clinical practice is still facing many methodological and technological limitations such as low detection sensitivity, limited sequencing capacity, lack of analytical methods for NAs therapeutics, and inadequate in vivo delivery. INT2ACT brings together 6 academic research units and 5 industrial partners to address these limitations by establishing new methods for detecting and analysing NAs in patient liquid biopsies, boosting available procedures for direct RNA sequencing, developing new methods for the synthesis and analysis of antisense oligonucleotides (ASO) libraries, identifying new RNA targets, and optimise NA therapeutics delivery systems. The concept of harnessing NAs in the realm of medicine opens doors to an array of possibilities, including the development of therapeutic vaccines for cancer and innovative ASO-based therapies for addressing a multitude of genetic disorders. While advancing NAs’ research and technologies, INT2ACT will also contribute to forming the next generation of highly skilled experts through an interdisciplinary and intersectoral training programme delivered to 15 Doctoral Candidates. The network-wide training programme is designed to ensure that all INT2ACT fellows will have the s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The contraction principle and martingales' under Fourth Framework.

assistant: **Concept**

Research objectives and content The contraction principle is one of the fundamental principles in the probability theory in Banach spaces. It consists in replacing a 'complicated' Banach space valued random variable by an 'easier' one where the corresponding absolute moments are comparable in at least one direction. This principle turned out to be powerful in several applications. Up to now the research has been concentrated on the situation that an unconditional sum of certain random variables represents the 'complicated' random variable whereas the 'easier' variable is a sum of independent Rademacher variables. My objective of the project consists in replacing the unconditional sums by sums of martingale differences and in replacing the Rademacher functions by other relevant families of random variables, such as stable and exponential ones. For a special case, the Gaussian variables, I have already proved a contraction principle with the help of Talagrand's majorizing measure theorem for Gaussian processes. Training content (objective, benefit and expected impact) The University Paris VI is a leading center in the interaction between probability theory and functional analysis and provides strong support in both parts of the project, the stochastic process part (for example M. Talagrand) and the part concerning Banach space valued martingales (G. Godefroy, G. Pisier, Q. Xu).