RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'LOw Cost CATastrophic Event Capturing' in the context of a Fifth Framework call.

assistant: **Objectives**

Effective search & rescue operations are amongst the most promising means to reduce human casualties following collapse of buildings due to catastrophic events.Time is critical for a successful rescue and the prompt availability of reliable information is vital. LOCCATEC could enhance significantly the effectiveness of the rescue management and operations, providing a quick survey tool to detect and locate trapped people.It is based on small, low-cost capturing devices to be pre-installed in buildings.Each capturing device, triggered by the event, records what happened in a given space during an eventual collapse.This information is downloaded wirelessly to central units providing the rescuers with a rapid estimate as to the number of people present in each building space at the moment of the event, the structural state of ruins and eventual possible pathways.Objectives:1. Development of a prototype system, which would provide the rescue teams quickly and cost-effectively reliable information on:a.The presence (or not) of people in each building space during a collapse;b.The state of the ruins (possible pathways, structural integrity).The LOCCATEC prototype will be a fully functional pre-industrial prototype, including at least one central unit and a number of capturing devices, the functionality of which will be tested against the specified requirements;2. Significant enhancement of the effectiveness of the rescue management and operations by providing a tool to perform a quick survey of the disaster site to detect and locate trapped people and plan the subsequent rescue operations in the quickest and most effective way.As part of an overall emergency response system, it would allow personnel, equipment and information to be dispatched where it is most needed and assis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Strengthening international salmonella surveillance through strain typing and differentiation (SALM-GENE)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Much salmonellas prevention depends on early outbreak recognition through surveillance. The value of traditional methods such as phage-typing to discriminate strains for surveillance is established. Gene printing is used for outbreaks when enhanced sub-typing is needed. In many countries, however, certain salmonella stereotypes and phage-types predominate, and research on the routine use of new methods of subdivision is needed. The proposal will involve ten national reference laboratories in answering the key question about the extent of the improvement in surveillance system power obtained when gene printing is routinely used. Molecular sub-typing will provide information on the international distribution of antibiotic-resistant clones. The study will comprehensively explore the feasibility and cost of laboratories using common molecular subtypingmethods to conduct international surveillance in real time.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Imaging nucleic acid metabolism in cells' (INAME) targeting Horizon 2020.

assistant: **Abstract**

In this project I, Pawan Kumar, a Nucleic Acid Chemist seek to team up with a pioneer in Nucleic Acid Chemistry and Biology (Professor Tom Brown) to carry out a highly interdisciplinary study at the University of Oxford to obtain deeper insights into DNA and RNA synthesis and metabolism in living cells and its application to cancer research. I propose to detect and quantify nucleic acid synthesis in proliferating cells by fluorescence without the requirement for toxic metal ions or antibodies. Earlier known methods such as [3H]thymidine and 5-bromo-2'-deoxyuridine labelling are either slow and labour intensive or require the use of harsh conditions. Incorporation of 5-ethynyl-2'-deoxyuridine into newly synthesized DNA  and its subsequent detection with an azide derivative of a fluorescent dye under copper catalyzed alkyne azide cycloaddition (CuAAC) reaction conditions presents a better alternative. However, cytotoxicity of copper salts restricts its use for living cells. I will use the strain promoted alkyne azide cycloaddition reaction, Diels-Alder reaction, and inverse electron demand Diels-Alder reaction to study cellular DNA and RNA. None of these reactions require the use of toxic metal salts. I will develop the conditions under which both DNA and RNA will be stable, so that it will be possible to isolate intact fluorescent nucleic acids from cells for detailed analysis. I will prepare the modified nucleosides and use them to label newly synthesized DNA and RNA in cells enabling their detection by reaction with fluorophores by using metal free click ligation reactions. The study will provide a better understanding of the mechanisms regulating DNA replication and the interplay between transcription and DNA replication. In the project  I will develop techniques to p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Small molecule inhibitors of bacterial communication - a new strategy for tackling antimicrobial resistance' under Horizon 2020.

assistant: **Concept**

Bacteria which are resistant to antibiotics currently result in 33,000 deaths per annum in Europe alone. Antimicrobial Resistance (AMR) will potentially cost the EU an estimated €1.5 billion annually in healthcare expenses and productivity losses. By 2050, 10 million people are expected to die each year as a result of AMR-related infections. New strategies are urgently required to deal with this growing crisis. One such strategy involves the disruption of native bacterial communication systems, also known as quorum sensing. Bacteria typically communicate with one another using a ‘language’ based on small messenger molecules. In this way, a colony of bacteria can co-ordinate their responses to environmental stresses, such as the administration of an antibiotic. These responses come under a variety of forms, but one of the most common is the production of biofilm, which shields the bacteria from the effects of the antibiotic. The aim of this COUNTERMAND project is analyse the messenger molecules utilised by bacteria which controls their resistance mechanisms. We will create new molecules which serve to confuse the bacteria, and prevent them from launching their resistance countermeasures. By blocking the formation of biofilms, the bacteria will again be vulnerable to the effects of antibiotics. We will adopt a multidisciplinary and collaborative approach combining the talents of chemists in Ireland and microbiologists across the EU to find the most effective inhibitor molecules. Importantly, this approach means that a new lease of life can be given to current antibiotics, without the expense and risk involved in the discovery of new antibiotics. This COUNTERMAND project represents a novel and promising solution to tackling AMR, offering significantly improved quality of l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Chromosome elimination in plant wide hybrids – explaining the phenomenon and applying lessons from a model system in Hordeum to problems of speciation, gene introgression and breeding new crop plants' in the context of a Seventh Framework call.

assistant: **Objectives**

Complete uniparental chromosome elimination occurs in some plant interspecific and intergeneric hybrid combinations. This phenomenon precludes viable hybrids from developing and results in haploid embryo formation of only one of the parents. It is, therefore, a major barrier for introgressing desirable traits from wild species into crop plants and breeding new crop species. We will investigate selective elimination of parental chromosomes during the development of hybrid embryos by using crosses in the genus Hordeum as a model since the degree of chromosome retention is influenced by parental genotype and environmental conditions after fertilisation. Once the crosses are made our aims are first, to establish whether a genome dosage exists to promote or retard elimination; second, to characterise the tissue-specific nature of elimination; and third, to identify which barley chromosomes are involved in elimination. We will use combined immunostaining methods and cytogenetic analyses to determine the activity and location of the highly conserved histone H3-like centromeric protein A (CENH3), which acts as a regulator of the mitosis-dependent elimination process. The knowledge gained should result in immense benefits accruing to agriculture by allowing the prediction of suitable crosses for either haploid or hybrid plants, both of which can be used in practical plant breeding programmes. Furthemore, we will make a huge step forward in our understanding of the interaction of parental genomes in newly-formed hybrids to provide valuable new insights into species evolution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Group Actions: Interactions between Dynamical Systems and Arithmetic' (GADA).

assistant: **Innovation**

Our main goal is to apply the powerful analytical tools that are now emerging from areas of more ""applicable"" parts of mathematics such as ergodic theory, random walks, harmonic analysis and additive combinatorics to some longstanding open problems in more theoretical parts of mathematics such as group theory and number theory. The recent work of Green and Tao about arithmetic progressions of prime numbers, or Margulis' celebrated solution of the Oppenheim Conjecture about integer values of quadratic forms are examples of the growing interpenetration of such seemingly unrelated fields. We have in mind an explicit set of problems: a uniform Tits alternative, the equidistribution of dense subgroups, the Andre-Oort conjecture, the spectral gap conjecture, the Lehmer problem. All these questions involve group theory in various forms (discrete subgroups of Lie groups, representation theory and spectral theory, locally symmetric spaces and Shimura varieties, dynamics on homogeneous spaces of arithmetic origin, Cayley graphs of large finite groups, etc) and have also a number theoretic flavor. Their striking common feature is that each of them enjoys some intimate relationship, whether by the foreseen methods to tackle it or by its consequences, with ergodic theory on the one hand and harmonic analysis and combinatorics on the other. We believe that the new methods being currently developed in those fields will bring crucial insights to the problems at hand. This proposed research builds on previous results obtained by the author and addresses some of the most challenging open problems in the field.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'ANXIETY IN INTERNATIONAL POLITICS: MEDIATING EFFECTS OF NORMS'.

assistant: **Concept**

This interdisciplinary research project examines how anxiety impacts individual –level political attitudes toward international issues, and in turn how prevalence of anxiety interacts with nativist and cosmopolitan norms in shaping international political attitudes. Bridging the fields of International Relations (IR), Psychology, and Philosophy, the research project will contribute to the distinct but related literatures on ontological security, emotions, and norms in IR with a systematic analysis of anxiety. In its outgoing phase at the University of British Columbia, the research will focus on the development of a novel conceptual/ analytical framework linking anxiety, norms, narratives and international political attitudes drawing primarily on existentialist philosophy and terror management theory in psychology. In the second phase at University of Columbia and the third phase at Koc University, the research will derive comparative cross-cultural findings from experimental analyses conducted with university students at UBC in the outgoing phase and at Koc University (KU) in the reintegration phase.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nanocatalytic drugs towards Alzheimer's disease', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Here is proposed nano-scale synthesis and combinatorial screening of medium sized peptide-transition metal catalyst libraries with the aim of producing libraries for screening highly selective catalysts for development of nano-medicines. The implementation of catalytic molecules as medicines is a new paradigm in treatment that can overcome a number of the difficulties with present drugs. As with real enzymes the enzyme capacity of these catalysts comes from productive and selective binding of the TS of reaction. The aim is to develop enzyme like molecules: Organozymes, characterized by high turnover as well as both high chemo- and high regio-selectivity. Novel ligands for transition metals containing functional groups will be synthesized and incorporated into encoded solid phase combinatorial libraries on bio-compatible resins. Encoding ensures extremely fast and simple structure/activity assessment. The screening of split-mix combinatorial libraries of organozymes will have the distinct purpose of developing of artificial proteases as drugs. This involves e. g. Fe, Zn and Cu peptide complexes and combinatorial FRET-substrate screening for proteolytic activity to identify artificial organozyme proteases that act as nano-medicine towards marker proteins in Alzheimers disease. Nano-container delivery of catalytic drugs to target tissue will be developed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'VALIDATION OF GENES POTENTIALLY RESPONSIBLE FOR THE TOLERANCE AND HEAVY METAL HYPERACCUMULATION ABILITY IN HIGHER PLANTS USING QTL MAPPING AND THE TOOLS OF MOLECULAR EVOLUTION'.

assistant: **Concept**

A rare class of plants named hyperaccumulators can tolerate heavy metals and also accumulate such metals to extremely high concentrations in their shoots. Classical techniques of screening have given clues to isolated genes involved in metal tolerance and homeostasis. However, their direct relationship with metal adaptation has not yet been established and the major genes of tolerance remain to be identified. Within the Arabidopsis genus, A. halleri has been shown to tolerate and hyperaccumulate Zn constitu tively while other species do not tolerate Zn (A. thaliana, A. lyrata). Interspecific crosses between A. halleri and A. lyrata, led to the mapping of three QTL regions for Zn tolerance. Within A. halleri species, a wide range of quantitative variation for tolerance has been measured among populations covering the natural area of distribution of the species. Genotypes that showed high and low tolerance were isolated from metallicolous and non-metallicolous populations respectively. We propose to use this exc eptional biological material to map candidate genes, to identify which of them are localised in QTL regions of tolerance, and to test, through the analysis of sequence variation among alleles, which genes are involved in the metal-tolerance adaptation at t he inter- and intra-specific level. This multidisciplinary approach integrates results obtained at the molecular, functional and ecological levels and will offer new perspectives on the study of the molecular and evolutionary processes responsible for meta l tolerance. This project will contribute to a better understanding of metal tolerance, hyperaccummulation and homeostasis. We believe that this action will help to increase the level of excellence of European scientists and also aid in the development of an E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Reduction of manual finishing by automated manufacturing of dies and moulds (AMADEUS)'.

assistant: **Innovation**

In die and mould industry the finishing process of the work pieces is carried out manually. The manual work is hard labour, very time consuming (33%) and responsible for about 30% of total costs. This manual process will be reduced by AMADEUS to less than 50%. As a result the production time and the total costs can be reduced. For automation of the manual process two grinding processes - belt grinding and grinding with small grinding wheels - will be integrated into a milling centre, for machining of dies and moulds in a single fixture. This will lead to less preparation time, higher geometrically accuracy and less floor space needed for storage of the workpieces. As an effect the flexibility and competitiveness of the European die and mould industry will rise. The working conditions will be improved, current jobs will be protected and higher skilled jobs will be created.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Identification of engrailed target genes' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content: Engrailed-1/2 is a homeoprotein that plays an important role in mid-hindbrain development. My goal is to identify genes under Engrailed-1/2 transcriptional control, to study their expression and analyze their function. To this end W. Wurst and A. Prochiantz have designed a gene trap strategy in which the LacZ gene integrated in the genome of ES cells is used as a reporter. The screen is based on the capability of the Engrailed-2-homeodomain (En-2HD) internalized by ES cells to antagonize the activity of endogenous Engrailed-1/2 and modify the transcription of Engrailed-1/2-controlled genes. This approach has already allowed to characterize Dystonin as a true Engrailed-1/2 target. I will characterize three Engrailed-1/2 responding ES cell clones by identifying the corresponding genes, to study their expression and functional role. In a complementary approach, based on the internalization of En-2HD by midbrain-hindbrain neurons, I will use differential RNA display (DRD) to identify putative targets of Engrailed-1/2 involved at later stages of neurogenesis. In practice, I have already performed the DRD which have led to the cloning of several differential displayed PCR fragments that need to be fully characterized to initiate functional studies. Training content (objective, benefit and expected impact): During my postdoctoral stay I will benefit from the expertise of my host laboratory to complete my theoretical and practical training in developmental neurobiology. The collaboration with W. Wurst's laboratory in Munich (GSF) will allow me to generate homozygous mouse mutants in the best conditions and will give me access to the already existing En-l-- and En-2-- mice. The contact with the latter outstanding laboratory in my home-country wil