RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'REspiratory Science Promoted by International Research Exchanges 4' (RESPIRE4) targeting Horizon 2020.

assistant: **Abstract**

The European Respiratory Society (ERS) is the largest society of lung clinicians and scientists in Europe, with a growing international membership (more than 30,000 currently) in more than 160 countries. Its mission is to promote lung health and to drive globally standards for respiratory medicine. Since 1997, ERS has operated a wide portfolio of fellowships, promoting transnational mobility and career development of researchers within respiratory science. This included three Marie-Sklodowska Curie COFUND programmes (two under FP7 and one under Horizon2020). ERS is now proposing to build on the success and best practice developed during previous RESPIRE programmes and on an already established network of more than 100 host centres, through a new, next-generation RESPIRE4 scheme. The latter introduces further added value and innovative elements compared to the past, building on fellows' feedback and the external evaluation of the previous RESPIRE programmes. First of all, RESPIRE4 places major attention to flexibility for fellows via tailored secondment and extension schemes, notably in the non-academic sector. Second of all, the outreach and patient involvement components have been further strenghtened to enhance the impact of the programme.  Third, a country coefficient criteria has been introduced to continue to attract the most promising researchers. Lastly, the programme integrates returnees from a career break as well as less represented countries (COFUND 2018 list) in its planning. RESPIRE Marie Sklodowska-Curie fellows will also benefit from extensive opportunities in terms of training and networking, notably via the ERS flagship events (Lung Science Conference & International Congress) and wider ERS network. Therefore, the proposed RESPIRE4 programme will contri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Origin and Protection of Unstable Repetitive DNA Elements During Sexual Reproduction', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The objective of this proposal is to define the molecular basis behind the origin and protection of unstable repetitive DNA sequences during sexual reproduction. Eukaryotic genomes contain large amounts of repetitive elements that serve vital roles in cellular physiology. However, repetitive elements are intrinsically unstable, which is caused by a high likelihood for incorrect repair when DNA breaks form within repetitive elements. During sexual reproduction, numerous DNA breaks are actively introduced into the genome, and repetitive sequences particularly threaten genome stability during this specialized developmental program. We will use the repetitive budding yeast ribosomal (r)DNA array as a model locus to study repetitive DNA instability. Our previous work showed that the outermost elements of this large repetitive array (i.e. rDNA array boundaries) are DNA break ‘fragile sites’, which attract DNA breaks during sexual reproduction. Importantly, we isolated the first known enzymatic ‘anti-DNA break’ system, which minimizes DNA break formation at rDNA array boundaries and as such is crucially required to maintain genome stability.In the experiments outlined here, we will use a combination of genomics, molecular biology and biochemistry to: 1) Interrogate the origins of the vulnerability of the repetitive rDNA boundaries for DNA breaks, and2) Define how a first-in-class ‘anti-DNA break’ system locally protects against DNA break formation. These studies will serve as a paradigm for repetitive DNA instability, yielding major insights into the general principles that govern protection of vulnerable genomic elements during sexual reproduction. It is well established that incorrect repair of DNA breaks involving repetitive sequences during sexual reproduction causes a myr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Design and Application of a Travel Survey for European Long-distance Trips Based on an International Network of Expertise' in the context of a Fifth Framework call.

assistant: **Objectives**

This proposal is addressed to develop and implement an European Survey of long-distance mobility. Based on the existing knowledge a total survey design will be developed. This design will treat the respondents as customers and this one-to-one approach has been proved to be successful in motivating the citizens to participate. Combined with approved methods for data validation a high-quality database can be provided. A network with national institutions (ministries, statistical offices), which are responsible for travels surveys will be built up. They will be provided with the survey methodology and be trained to implement it. So a unique compatible survey method can be applied by national partners all over Europe and be repeated by a responsible institution (e. g. EUROSTAT).The results of this survey will be presented as mobility indicators describing long-distance mobility, as O-D matrices and as a database for researchers for further analysing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Gigascale Oriented Solid State flAsh Memory for EuRope' in the context of a Seventh Framework call.

assistant: **Objectives**

The project aims at the development of the technology for very high density Non Volatile Memories for mass storage applications down to the 2X nm technology node. The field is receiving increasing attention, due to the explosion of portable multimedia applications, and is forecasted to exceed 40 Billion US$ total available market by 2010. The dominant technology for this application is the floating gate NAND memory. However severe technological roadblocks (reduction in storage charge and electrostatic interference among neighboring cells) are limiting further scaling beyond the 32 nm node. Charge trapping in dielectric layers seems to be a viable alternative to floating gate. The main challenge is the integration of the different new materials, like tunnel dielectric, trapping layer, top dielectric, metal gate at the target technology node and the achievement of an acceptable trade-off between functionality and reliability (e.g. charge retention and endurance). The project will cover material development, cell architecture, modeling of material properties, trapping and conduction behavior in the dielectrics, metal gate materials. Initial studies could be performed on available technology 65-45nm (more relaxed for Universities and research centers) to arrive to full process integration and realization of full arrays in a technology in the 28-36 nm range (the best achievable with available lithography) by two major European semiconductor manufacturers. It will include memory characterization and reliability testing, with the additional aim of defining standards and procedures for reliability assessment. Technology options for higher integration densities, for a given lithography node, will be investigated with the help of public research partners. The final demonstrator w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'EXPANDing the value of Extracellular Vesicles as carriers of biomarker and therapy in precision healhcare'.

assistant: **Innovation**

Extracellular vesicles (EVs) have been identified as important signaling mediators in a myriad of physiological and pathological processes. There is an emerging effort to advance the exploitation of EVs in precision healthcare, with special emphasis on drug delivery and liquid biopsy. However, the current technology readiness level in the field and lack of standardized methodology guidelines are limiting the exploitation of EVs, so a significant leap toward the establishment of novel tools has to be made. EXPAND-EV’s main goal is to provide a unique solution for advancing the current diagnostic and therapeutic potential of EVs by developing and implementing versatile, scalable, cost-effective and reproducible purification systems, based on single-domain antibody affinity technology for high-performance scalable EVs capture, in two parallel lines of research: (I)the system will be validated in clinical laboratory settings on breast (BC), liver (HC) and lung cancer (LC) by analyzing differential expression of multi -omics (proteomic, glycomic and transcriptomic) EVs-related features, with the goal to develop a panel of biomarkers that would contribute in timely diagnostics, enable a convenient and non-invasive prognosis assessment and tailored therapy. (II)development of GMP-compliant protocol for producing edible plant EVs as carriers of therapeutic siRNA molecules. Their safety profile and therapeutic potential will be tested on BC, HC and LC cell lines and mouse models. By establishing a consortium composed of excellent research groups and SMEs across Europe, EXPAND-EV will bring forth the needed paradigm shift in EVs research by solving the major bottleneck issue in the field. Creating a simple, robust, cheap, scalable and reproducible EVs purification system will pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Emu and its impact on cohesion: policy challenges' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

EMU offers significant benefits to all participating Member States. The 'cohesion' countries and less-favored regions of the other Member States are likely to benefit particularly through improved economic development prospects but risks have been identified for less competitive economies. All Euro zone members may have regions sensitive to these effects and adjustment to the post-EMU policy environment may have consequences for economic and social cohesion. In the absence of other policy instruments it is supply side adjustment that is going to have to bear the burden of adjustment in EMU. This AM will review and synthesize research (from TSER and 5th Framework projects and other sources) on the impact of EMU on cohesion and the potential for supply side adjustment. This work will be disseminated via a briefing paper and a high-level workshop, and contribute to the research agenda of the 6th Framework Programme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Role of the SIRT7-NPM-c-Myc pathway in lung cancer'.

assistant: **Objectives**

Lung cancer is the second cause of death due to malignancy and diagnosed patients rarely survive beyond two years. Thus, unveiling the molecular mechanisms underlying lung tumorigenesis is imperative for development of novel therapeutic approaches. The nucleolar protein nucleophosmin (NPM) plays critical roles in cancer progression and is often deregulated in human malignancies. NPM employs distinct mechanisms to control cancer cells growth including regulation of the proto-oncogene c-Myc, a transcription factor often aberrantly activated in lung cancer. Recent studies highlighted the fundamental impact of post-translational modifications in controlling NPM functions. NPM is a deacetylation target of Sirtuin 7 (SIRT7), a member of a class of NAD+ dependent histone/protein deacetylases collectively known as sirtuins. Deacetylation of NPM by SIRT7 is fundamental to control NPM subcellular localization and stimulate NPM-mediated cellular stress responses. SIRT7 also acts as a potent oncogene in different malignancies although through still poorly characterized mechanisms. Thus, SIRT7-LC aims to characterize the impact of the SIRT7-NPM axis on regulation of c-Myc pro-oncogenic activities and its impact on lung cancer cells proliferation in vitro and in vivo, as well as possible aberrant activation of this pathway in human lung cancers and its correlation with prognosis. Thus, SIRT7-LC may lead to identification of novel molecular mechanisms sustaining lung cancer growth that could be targeted for therapeutic interventions. Dr. Alejandro Vaquero, a world-leading expert in the sirtuins field, will supervise this project. His competence in the field together with my expertise in characterization of mouse models of diseases will undoubtedly ensure successful realization of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Geometry of moduli spaces of bundles over curves' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The researcher C. Pauly plans to investigate several problems related to the geometry of moduli spaces of vector bundles over curves. The proposal deals with three different aspects: conformal blocks and the Hitchin/WZW connection, vector bundles in positive characteristic and the projective geometry of moduli spaces. Research will be undertaken at the Laboratoire J. A. Dieudonné of the University of Nice Sophia Antipolis in collaboration with experts in the different research areas. The research programme includes research visits of experts to the University of Nice, the organization of an international conference, of a school for young researchers, and a one-year post-doctoral position.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Centre of Excellence in exascale-oriented application co-design and delivery for multiscale simulations' (MultiXscale).

assistant: **Concept**

The MultiXscale Centre of Excellence will increase performance, productivity and portability (“the Three P's”) across the entire spectrum of scientists active in the domain of multiscale simulation. It couples the scientific expertise of the CECAM network, represented by leading experts in multiscale simulations from different European institutions, with the technical expertise of the EESSI collaboration, and targets the computational laboratories of EuroHPC and beyond. It will shoulder much of the technical burden of developing and distributing domain-relevant applications for (pre-)exascale through application co-design for exascale technologies, and the provisioning of exascale-oriented  libraries and services that nudge the community to adopt battle-tested, future-oriented, scalable workflows and portable technologies. Together, these will allow application developers to pursue domain-relevant scientific innovation without being over-burdened by technical detail, and empower industrial and academic application users to painlessly adopt bleeding-edge technologies from the domain on whatever computational resource they may have access to. To drive the development of the libraries and services, and to showcase the scientific and industrial potential of truly multiscale approaches, MultiXscale will pursue three pilot use cases of societal and industrial significance:·helicopter design and certification for civil transport,·battery applications to support the sustainable energy transition,·ultrasound for non-invasive diagnostics and biomedical applications.MultiXscale will extend the applications, user-base and domains actively engaged in the current CoE and EuroHPC ecosystem by addressing specific and critical needs, and advancing the transition towards use of exascale
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'e-IRG Support Programme 4 (e-IRGSP4)', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The e-Infrastructure Reflection Group Support Programme 4 (e-IRGSP4) intends to provide support for the e-Infrastructure Reflection Group (e-IRG) and hereby supports the collaboration of national and pan-European e-Infrastructure initiatives and stakeholders.  The e-IRG reflects on results and developments in the area of e-infrastructures. It consists of government appointed national representatives and was created in 2003. The e-IRG has reached a high ranking position as an independent advisory body in Europe in its field. It cooperates increasingly closer with the European Strategy Forum on Research Infrastructures (ESFRI), whose work it largely complements through its lateral domain. The e-IRG produces White and Blue Papers, Roadmaps and other policy-related documents, covering the whole domain of e-infrastructures: networks, high-performance and high-throughput computing installations and data infrastructures. The e-IRG formulates its conclusions and advice in various ways. The e-IRG Recommendations endorsed by the e-IRG delegates are well received by the communities concerned as well as by policy makers and funding agencies and can thus have very serious impact.The e-IRGSP4 project builds on the experiences of previous e-IRG support programmes. It is lightweight designed focusing on the core requirements of the e-IRG and the demands of the European Commission. It provides the secretariat of the e-IRG community, supports the e-IRG Chair and Executive Board, organises workshops, which facilitate the coordination and communication between e-Infrastructure initiatives and stakeholders.The policy creating process of the e-IRG is supported by monitoring and analysing the state-of-the-art developments in the fields of interest of the e-IRG (at policy, technology, research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New fields of research in earthquake engineering experimentation' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Description:Objectives: To pursue research in the following 6 areas of earthquake engineering:1. Controlled testing in the non-linear range of material behaviour;2. The complementarity of shaking tables and reaction walls;3. Reliability of qualification tests performed on shaking tables;4. Sub-structuring methods on shaking tables;5. Multiple support input to large structures;6. Continuous pseudodynamic testing with substructuring.Results:The research programme starts on 1 December 2001Project Manager:Prof. R T Severn, Earthquake Engineering Research Centre, University of Bristol, BS8 1TR, UKPhone: +44-117-9287708Fax: +44-117-9287783E-mail: Janet.Davies@bristol.ac.uk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'LARGE-SCALE SOLAR DOMESTIC HOT WATER SYSTEMS IN NORTHWEST EUROPE', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

- Cost reduction of SDHW systems by realisation of large-scale projects for various countries.- Integration of SDHW systems in project development, architectural design, the building process, the conventional installation of large scale housing developments. Special attention for the implementation of quality control schemes already developed and architectural integration.- International knowledge transfer and exchange regarding the above aspects.- Realisation of over 3000 SDHW systems in 6 EU-countries by realisation of large-scale SDHW projects (100 to 1000 systems each in Denmark, Sweden, Germany, and The Netherlands and realisation of medium-scale SDHW projects 'approx. 100 systems each) in Belgium an the United Kingdom.- Promotion of intra-community trade via public Call for tenders.INNOVATION :- The procedure of realisation of large-scale SDHW projects.- The promotion of intra-community trade via a public Call for tenders.CONTEXT :Solar Domestic Hot Water (SDHW) is becoming a mature technology. In the past 20 years, R&D has led to significant improvements in cost-effectiveness of standard systems for family households. For a large-scale market introduction, a further cost-reduction is necessary, accompanied by rigorous quality control.Two tracks should be followed at the same time:- continuing R&D leading to lower manufacturing cost.- large-scale project development, reducing selling and installation cost. This can reduce system cost by as much as 40%.Favourable experience with the latter approach has been gained in an ongoing Thermie-project in The Netherlands (SE/479/92/NL), also known as the Apeldoorn Solar Project. In this project, now halfway, 1000 SDHW systems are being installed in a new housing development.ECONOMIC ASPECTS :The average payback time of the