RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integration of Biomass and Waste for Energy into Local Authority Energy Systems' (INTEGRATE) under Fifth Framework.

assistant: **Objectives**

1. To examine EU experience on the public acceptability of schemes for energy from waste and biomass residues, including comparisons of successful and unsuccessful schemes;2. To transfer this experience to regions where there are extensive problems with acceptance of incineration of energy from waste and biomass residues, through a workshop for appropriate local authority personnel;3. To organise a study tour of successful systems;4. To make recommendations on public consultation to improve acceptability of energy from waste and biomass residues;5. To identify local authorities interested in such schemes and willing to be monitored through public consultation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel high speed and high resolution microscopy setup for cytoarchitectonic studies of mesoscale sized human brain tissues, healthy and affected by Focal Cortical Dysplasia' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The human brain is a massively complex information processing system with a hierarchy of different yet tightly integrated levels of organization. From such intricate interplay emerge our personality, emotions, memory and decision making capabilities, but unwrapping the mysteries of the brain functioning represents a huge challenge.Recent progress in microscopy, neurobiology and neuroinformatics has stimulated the launch of large research programs such as Human Brain Project and BRAIN. An open problem is how to investigate with both high resolution and high speed the brain structure over mesoscale (millimiters to centimeters) sized regions, which would provide unique insight on the neuroanatonomy across different functional areas. This research project will develop a novel dual-view inverted dual-slit confocal light sheet microscope, capable of resolving sub-cellular morphology over centimeter-sized tissues at beyond state of the art acquisition speed. This instrument will be used to perform a comparative cytoarchitectonic investigation of mesoscale human brain tissues, both healthy and affected by Focal Cortical Dysplasia, leveraging an advanced machine learning image analysis algorithm. Such study will greatly advance the medical and neurobiological understanding of the effects of neuro-degenerative pathologies and the obtained data will be contributed to existing human brain atlases as a foundation for brain models.The applicant’s well-rounded skill set, acquired in cold atom physics and ranging from optics to hardware control, is a perfect match for building the proposed setup and for a fruitful two-way transfer of knowledge with the host, expert in advanced neuro microscopy.This research project will strengthen the competitiveness of European science and shine new l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Improvement of techniques for multiscale modelling of irradiated materials' (ITEM) targeting Fifth Framework.

assistant: **Abstract**

The objective of the proposed Thematic Network is to ensure that the developments required to simulate quantitatively irradiation effects in materials are performed rapidly and in a co-ordinated way in Europe. For the European nuclear industry this is a great opportunity to lead such an international effort in the direction of its interest. The Participants in the Network will be EU Organisations involved in the development of codes and models for computational multiscale modelling and/or in experimental studies concerning radiation effects in materials. Institutes from Eastern countries are also invited and the Network will have close relations with equivalent structures in the United States and Japan. Each Participant will keep financing its own scientific activities, but these will be co-ordinated within the structure of the Network by the leading Network organisation.The use of test reactors and hot cell facilities becomes more and more problematic. One way of partially solving this problem is to develop tools for computer simulation of the effects of irradiation in materials.The development of such tools (called Virtual Test Reactors: VTRs) began recently (1998) on specific issues with current simulation techniques. However, it is paramount to prepare anew generation of techniques, which will allow to enlarge the application field of VTRs within a few years. The objective of the proposed Thematic Network is to ensure that these developments are performed rapidly and in a co-ordinated way in Europe. For the European nuclear industry, this is a great opportunity to lead such an international effort in the direction of its interest. Multi-scale modelling approach is also being aggressively pursued in the US and in Japan. The Network will allow Europe to exchange infor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'FaInt Supernovae and Hypernovae: Mechanism and Nucleosynthesis'.

assistant: **Objectives**

Massive stars of 8-140M⊙ undergo core-collapse at the end of their evolution, leading to a central neutron star or possibly a black hole. Stars in the mass range of 140-260M⊙ have been expected to experience thermonuclear explosions, known in the literature as pair instability supernovae (PISNe). More massive objects will form black holes during their final collapse. If these events lead to ejecta, they will have experienced explosive burning, possibly under the strong influence of interactions with neutrinos. The impact of the most massive objects will enter at the earliest stages of the evolution of galaxies, influencing the abundance pattern visible in the spectra of extremely low metallicity stars, both topics of extremely active research. Apparently one does not observe the abundance yields expected from PISNe, indicating that probably all very massive stars underwent strong mass loss during their evolution and undergo final core collapse. It is still an open issue, whether and how this collapse leads to neutron star formation or black holes (possibly also occurring subsequently), forming as a function of progenitor mass supernova events (SNe), faint supernovae with fallback from the innermost ejected zones (faint SNe), or hypernovae/collapsars/gamma-ray bursts (GRBs) in conjunction with rotation, magnetic fields and highly energetic explosions. The focus of the present proposal is this transition region in stellar progenitor mass and its nucleosynthesis contributions to galactic evolution, linking diverse research fields like nuclear physics far from stability, the equation of state of dense objects, 3D magnetohydrodynamics with neutrino transport, and computational methods. The outcome is of extreme importance in understanding the nucleosynthesis impact of the fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SEA Applied to the Prediction of High Frequency Vibrations in Aircraft Engines' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Designed to achieve reduction in fuel consumption, the Ultra-High Bypass and High Propulsive Efficiency Geared Turbofan engine incorporates evolutions likely to produce high frequency (HF) vibration excitations which propagate through the structure. Numerical simulation is an efficient tool to control vibrations hence supporting the mechanical design. Where Finite Element (FE) based approaches show limitations due to computational hardware performances and HF dispersion management, Statistical Energy Analysis (SEA) stand as proven and effective method for this frequency range to predict the vibrational energy transfers across partitions – subsystems – of a structure. Challenges of SEA modelling consist of the structure partitioning which usually requires expertise and the accuracy loss at lower frequencies where the high stiffness of parts or complexity of junctions counter the method initial assumptions. Those statements depend strongly on the studied structure, therefore the objective of the proposed project is to develop and demonstrate a SEA modelling process to predict the vibration propagated in a typical complex engine frame. In this scope, best modelling practices from detailed numerical analysis are engaged to both support an extensive test campaign preparation including test vehicle design and manufacture, and produce models covering the target frequency range: from 400Hz to 10kHz. A crucial phase consists in the validation and update of these models from tests post-processing techniques and known methods such as Experimental SEA, Decay Rate damping estimation or input conductance as well as innovative inverse approaches relying on optimization loops. From the comprehensive comparison of these different methods with tests results, a best methods and associated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Suicidality: Treatment Occurring in Paediatrics' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The emergence of suicidality in patients receiving drug treatment is of concern because of the overall burden and the possible link with completed suicide. The lack of uniform requirements for defining, detecting and recording suicidality and the presence of disease related confounders create major problems. It is possible that Medication-Related Suicidality (MRS) differs from Psychopathology-Related Suicidality (PRS) in terms of phenomenology, clinical expression and time course, and may vary between children and adults. Unlike PRS, the time-course of MRS may be associated with possible differences in drug pharmacokinetics; abrupt onset; absence of suicidality prior to start of medication; and emergence of suicidality related co-morbidities after treatment.This proposal will focus on developing a web-based comprehensive methodology for the assessment and monitoring of suicidality and its mediators in children and adolescents using the HealthTrackerTM (a paediatric web-based health outcome monitoring system), with the aim of developing a Suicidality Assessment and Monitoring Module, a Bio-psycho-social Mediators of Suicidality Assessment Module, and a Suicidality-Related Psychiatric and Physical Illness Module. The information obtained will be used to computer-generate classification of suicidality using the Classification of Suicide-Related Thoughts and Behaviour (Silverman et al, 2007) and the Columbia Classification Algorithm of Suicidal Assessment (C-CASA) (Posner et al, 2007). The existing Medication Characteristics Module will be expanded to allow documentation of pharmacological characteristics of medication, to explore whether they mediate MRS. The methodology will then be tested in 3 paediatric observational trials (risperidone in conduct disorder; fluoxetine i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'MATHS@IHP CNRS UMS839' in the context of a Sixth Framework call.

assistant: **Objectives**

The Institut Henri-Poincare is a Research Center devoted to mathematics and theoretical physics. Since 1994 it has hosted international thematic research programs which are organized at the Emile Borel Centre. The training of young scientists is one of t he essential missions of the Center. The fact that the programmes are run on a quaterly basis makes it ideally suited for that purpose. During their three months stay the students attend a series of doctoral courses organized in a progressive and coherent way that are given by some of the world leading experts intheir research area.The list of the coming programs in mathematics clearly demonstrates our will to promote interdisciplinary research of top level. A - April 2006-July 2006 : Phenomena in large dim ensions. B - January 2007-April 2007 : Groupoïds and Stacks in physics and geometry. C - April 2008 - July 2008 : Ricci curvature, ricci flows and applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'METAdiag: Diagnose to Cure' (METAdiag).

assistant: **Concept**

As all living organisms, our cells need to feed on a balanced diet to stay healthy and correctly function. To do that, cells adapt their nutrient consumption according to their energetic needs. If the uptake mechanism is impaired, it impacts cell metabolism. Both starving cells & overfeeding cells are a hallmark for the onset and progress of serious diseases like diabetes, cancer or inborn errors of metabolism, which can all be seen as metabolic diseases. These are debilitating conditions that need lifelong treatments, entail poorer life quality and incur a major economic burden. Subjects appear initially healthy and symptoms are often overlooked, but by the time of diagnosis, damage can no longer be reverted. Conversely, early detection could prevent most of the damages by starting specific therapies. However, despite the fact that all metabolic diseases have abnormal cell energetics, there are no tests for cell metabolism in clinical practice. In response, we at METAFORA aim to bring to market METAdiag, the first diagnostic platform able to assess and monitor the metabolic status of our cells. This unique and non-invasive diagnostic system is able to detect abnormal cell energetics by quantifying the levels of nutrient transporters at the cell surface. After proving the reliability and accuracy of our platform at a small scale, we now aim to take a step further towards the market. Thus, in Phase 1 we aim to conduct a Feasibility Study that will help us to assess and achieve the significant milestones influencing the project from the technical, commercial and financial perspectives. Based on proprietary technology and on a strong collaboration network, METAdiag will be uniquely positioned to detect metabolic impairments, allowing clinicians to achieve an earlier diagno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Environmentally-induced Developmental Origins of Health and Disease' (E-DOHAD) under Seventh Framework.

assistant: **Objectives**

The DOHaD (Developmental Origins of Health and Disease) hypothesis states that, because of developmental plasticity, in utero and early postnatal stressors can increase chronic disease risk in childhood and later. Alterations of epigenetic marks, impacting on gene expression, are one mechanism that could explain such long-term impact. These hypotheses have so far been tested mostly in animals, and little for atmospheric pollutants, for which animal evidence is scarce.We aim to characterize the impact of environmental exposures on childhood health. Our focus is on two families of pollutants with a highly prevalent and controllable exposure in humans: atmospheric pollutants and specific high-volume non-persistent chemicals (Bisphenol A, other phenols and phthalates). These pollutants are archetypal of modern life pollutants challenging environmental health research. We will set up a new type of mother-child cohort with early recruitment in pregnancy, intense follow-up (including geolocalisation of subjects with GPS combined with fine-scale air pollution modelling), personal exposure monitoring, repeated collection of biological samples. Transcriptomic analysis, non-invasive clinical examinations (Doppler and ultrasound imaging, ECG, early postnatal evaluation of lung function) will bring clues regarding target functions. This observational approach in humans will be supplemented by an animal experiment aiming at characterizing the impact of in utero exposure to traffic-related atmospheric pollutants on foetal development and health in adulthood, and characterizing target functions and organs more finely than the human study can allow.E-DOHaD spans over the whole range of environmental health disciplines, with epidemiologic and toxicologic studies being conducted in parall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Rapid microbial adapation via horizontal gene transfer: environmental management opportunities and public health concerns' under Sixth Framework.

assistant: **Concept**

Horizontal gene transfer (HGT) is a central process in microbial adaptation to xenobiotic chemicals, but also in their gain or loss of pathogenicity. The goal of the proposed research is to examine, describe, and control the incidence of extant HGT in microbial bio-film communities found in groundwater and drinking water treatment and distribution systems. The results of this project will answer questions with acute environmental and public health relevance: Can this natural process of rapid microbial adaptation (RaMAda) via HGT be harnessed to steer microbial attenuation of pesticide laden groundwaters? Does HGT need to be considered in a precautionary fashion when examining the fate of pathogenic traits in a drinking water distribution context? This project will employ advanced methods like novel molecular biomarkers to permit single-cell resolved detection of microbial growth and gene transfer dynamics; advanced microscopic tools and image analysis, innovative biomathematical approaches to model microbial a ctivity from individual cell behavior to yield emergent system properties, and environmentally relevant biological and physico-chemical materials and conditions. This study can lead to innovative approaches to detoxify pesticide-laden groundwaters, and may drastically reform fate assessment of pathogenic and bioterrorism micro-organisms by explicit consideration of the survival of their horizontally transmissible genes. The central core of the proposal responds directly to 6th FP's call for enhancement and structuring of the European Research Area via its HRM activity. It will support 2 early and 2 mid-career scientists who will join a trans-national, leading-edge, and interdisciplinary research programme with European dimension, built around a young EU researcher
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of a Point of Care microfluidic chip unit and self-sampling device for cervical cancer screening and platform technology for Nucleic Acid Detection at the Point of Care' in the context of a Seventh Framework call.

assistant: **Objectives**

In SelfPOCNAD, we propose to develop an industrial prototype for a rapid (“same day”) Cervical Cancer screening of self-taken patient samples. The industrial prototype will only include enough sample from the self-taken sample in order not to risk any clogging of the sample preparation chip. The first industrial prototype will include the detection of oncogenic E6/E7 mRNA from in total 9 HPV types with an option to detect up to 19 HPV types based on detection developed for Pre-Tect HPV-Proofer laboratory kit, Nucleic Acid Sequence Based Amplification. Introduction of SelfPOCNAD at Point of Care is expected to significantly improve compliance of women with Cervical Cancer screening programs Increased compliance of women with the ICC screening programs will drastically decrease the ICC incidence and save lives. ICC is the second most common cancer in women. Each year, there are over 470,000 new cases globally. Of these, 33,000 are in the EU. Once the disease is established, it is hard to cure, so each year 233,000 women die - 15,000 in the EU . After breast cancer, it is the second-most-common cancer amongst women. However, this is a preventable and treatable disease, if detected in the early stages. Some EU member states have well-organised screening and effective prevention programmes. But better compliance with screening, especially in New Member States could save the lives of 3-5,000 European women p.a.