RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Kinematic modeling of a human-arm like robot manipulator', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The project is as well motivated by the increasing demand for high performance robots as by an improvement of the man-machine interface in telerobotic tasks. In the project the human shoulder, arm and wrist are analyzed to derive two models: - A 'close-to-nature' model, that represents the real characteristics of the human arm. - A 'technical' robot model, that serves as prototyping study of a human-arm-like robot manipulator. Technical feasibility is investigated. The design, evaluation and comparison of the models will be accompanied by a detailed workspace analysis. Here the kinematic characteristics (criteria of manipulability) are analysed as a function of workspace position. Finally, the results are interpreted to improve man-machine interaction in telerobotic systems: - Ergonomic guidelines for force reflecting master devices are developed. - Zones of high kinematic performance are investigated to improve the mapping between master device and slave. Training content (objective, benefit and expected impact) - General view in methods and applications of robotics are provided by doctoral lectures and industrial seminars. - The project provides for: - Theoretical know-how: Robot mechanics, control and simulation - Practical know-how: Robot design, programming and ergonomics - Direct cooperation with industrial R&D The training will qualify Mr. Schafer not only to develop robotic systems for new industrial applications but also to advance robotic research in key issues on an academical level.  Links with industry / industrial relevance (22) - Direct links: Iberdrola, LISSMAC, MENASA, AUXINI, Berghof, Schenking, Mayer, Cobra - Industry relevance: Flexible manufacturing systems, construction, medicine, mining, agriculture, entertainment e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Networked Organisations - Research into Standards' (NO-REST) targeting Sixth Framework.

assistant: **Abstract**

The NO-REST project aims to investigate the applicability and dynamics of standards in the e-business and e-government sectors, and to develop toolkits for the assessment of their performance, and of the impact they have on networked organisations. To this end, NO-REST will evaluate the various standards development platforms, examine how implementations affect standards and interoperability, and do a re-active performance analysis of standards as well as a pro-active integrated impact assessment.NO-REST will look at the application of standards, and will analyse how standards, and their implementations, are subject to change incurred by the environment within which they are implemented. The project will then devise an analytical framework for a causal model of such changes. This, in turn, will help understand the nature of these changes and will allow for the formulation of adequate counter-measures or - even better - for the derivation of conclusions for developing standards in the future, and possible mechanisms to feed back these changes continuously into dynamic standards building. The project will also analyse the various standards setting organisations, with a focus on how they react to - and influence - the dynamics of the environment within which they work. This will also include an analysis of the relation between the 'credibility' of a standards setting organisation, i.e., to which extent does the origin of a standard influence its viability in the market place.The project will then establish if, and how, a standard's origin affects its performance, and will set up guidelines helping those who wish to create a standard decide which standards setting organisation to select. Finally, based on the above, NO-REST will develop, and apply, a methodology to help ass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'GI.service: Asset performance optimiser' (GIservice) under Horizon 2020.

assistant: **Objectives**

The global energy market is changing from a central supply concept to a decentralized system, resulting in changes in investments at various levels. For example, in 2015, for the first time ever, investments in renewable energies were higher than in conventional energies (fossil, nuclear). Since 2011, approximately €281 billion have been invested annually in renewable sources. Many established energy supply companies are also changing their strategy and want to focus on renewable energy generation, service and sales. GI.service will suppose a step ahead in the state of the art of Energy Management Systems (EnMS). The main asset is its superior degree of accuracy in measurements, which is reached by the combination of our proprietary HW measuring devices and our in-house SW modules for data acquisition, storage, analysis and exploitation. Based on this capacity, we have been able to create a unique set of features that are not offered by the alternatives in the market for the optimisation of: power generation plants (up to 10% more production and risk reduction), second life of high-capacity used batteries (up to 8% better capacity utilization), energy distribution grids (up to 10% more efficient and optimized), energy-related assets (up to 15% longer lifespan of assets) and other advanced features for decision making on energy efficiency and assets. The targeted field is promising: the global EnMS market is expected to grow from €20.76 billion in 2015 to €52.76 billion by 2020, at a CAGR of 20.5%, with the industrial applications supposing 60% to 70% of this market. In addition, the global market of energy generation supposes a convenient scenario for the commercialisation of GI.service, with a total size of €1,900 billion. Especially relevant is the renewable energies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unraveling the conceptional novel ADAM17 regulation by PP2A in metastasis formation.' (UNNAMEd-2).

assistant: **Concept**

Around 90% of all cancer-related deaths are due to metastasis. Understanding the process of cancer metastasis is therefore of urgent need to develop new treatments. Aberrant expression of the epidermal growth factor receptor (EGFR), or increased availability of its ligands promote tumour survival and metastasis in multiple cancers. As a result, several anti-EGFR therapeutics are in clinical use, but almost all patients will develop resistance against the treatment. Another strategy to treat EGFR driven cancers is to reduce the pool of available EGFR ligands. The crucial enzyme in EGFR ligand release is A Disintegrin And Metalloproteinase (ADAM) 17. I have unpublished data showing that depletion of ADAM17 significantly inhibits colon cancer growth and metastasis in vivo. However, anti-ADAM17 therapies have failed clinically and thus, we urgently need to understand the regulation of ADAM17. Recent discoveries by Dr. Kveiborg’s group, and collaborators showed that the protein phosphatase PP2A binds to ADAM17, and negatively regulates EGFR ligand release, thereby representing the first known negative regulator for ADAM17. Based on these novel findings, I hypothesize that the PP2A-ADAM17-EGFR axis has the ability to control cancer metastasis. To test this hypothesis, I aim to characterize the functional impact of the PP2A-ADAM17 interaction in cancer spread by creating ADAM17 mutants with different PP2A binding properties in colon cancer cells using CRISPR/Cas9 and functionally evaluate these cells in vitro and in zebrafish and mouse models. Moreover, I aim to unravel the molecular mechanisms of the interplay; applying SILAC coupled mass spectrometry and mutagenesis screening, to evaluate the mechanism by which PP2A affects ADAM17, and the signals involved in PP2A binding. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Multi messenger Imaging of Cancer'.

assistant: **Concept**

Cancer remains the second leading cause of death worldwide (World Health Organization), involving various pathological processes across multiple biological scales . Ultrasound is increasingly used in clinical oncological practice for patient diagnosis, therapy guidance, and monitoring, however do not allow for imaging of  the metabolic and vascular onset of cancer at the microscale . Here, I aim to develop multi-messenger ultrasound imaging for the early metabolic and vascular detection of cancer in a pre-clinical model and a pilot human head and neck oncology study. This interdisciplinary proposal will build on three recent breakthroughs in ultrasound and synthetic biology: (1) 4D ultrasound imaging at the millisecond timescale, (2) ultrasound super-resolution imaging at the microvascular scale and (3) biomolecular ultrasound imaging at the cellular scale.I will develop non-linear sound sheet imaging (NSSI) for the 3D imaging of ultrasound contrast agents regardless of their motion. Combined with localization algorithms, this method will enable 3D ultrasound microscopy (SSLM) of capillary networks perfused with clinically approved contrast agents. Using this vascular message we will characterize rat brain tumors in preclinical research. We will also evaluate the potential of the ultrasound microscopy technique to detect metastatic sentinel lymph nodes in a pilot human study. Furthermore, NSSI will be capable of imaging GVs that are small enough to extravasate the leaky vasculature of tumors.  In this specific aim, I will rely on genetically engineered pH-sensing GVs developed in my host laboratory (NWO Start-up Grant STU.019.021 of the Dutch Research Council). Using this metabolic message we will detect hypoxia induced acidosis, an important biomarker of cancer. The no
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'EU taxation and third countries' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The increasing interdependence of national economies and the globalization lead to new possibilities and risks related to cross-border taxation for investors and governments. To minimize the risks and to support the possibilities for European and third countries, alternatives to national fiscal sovereignty, i.e. various forms of treaties on a bilateral or supra-national level, may be required. Within the joint exchange programme we want to provide answers to specific issues raised in the scientific and political debate on EU taxation and third countries within an area where countries are striving for economic integration and also in the light of recent changes in the well established Model Conventions and their Commentaries. The overall topic of “EU taxation and third countries” will be explored in four work packages: (1) Income tax treaties - the importance and effect of treaty commentaries, (2) Corporate Tax Consolidation Regimes for multijurisdictional companies in relation to non-resident companies, (3) Recent developments in tax treaties in the light of recent changes in OECD and UN Model Conventions and Commentaries, and (4) Improving VAT and GST systems. The transfer of knowledge between the EU (Austria, The Netherlands) and third countries (South Africa, Brazil) will be achieved by several instruments. Before, during and after the research exchange, the seconded staff will be optimally supported: there will be activities organized by the home institution (e.g. round tables, presentations...) and the researchers will also be integrated to the activities at the host institution during their research stay (e.g. discussions, preparation of joint publications...). The project will therefore intensively contribute to coordination and cooperation of high quality resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Eucor Upper Rhine Immunology doctoral programme' under Horizon 2020.

assistant: **Concept**

EURIdoc is a Eucor - The European Campus joint doctoral programme in the field of immunology. Doctoral students are selected through a transparent, merit-based and international recruitment process and hired by the Eucor members University of Basel (Switzerland), University of Freiburg (Germany), Karlsruhe Institute of Technology (Germany), University of Strasbourg (France) and the Freiburg University Clinic (Germany). The programme is strongly connected to the regional, tri-national ecosystem of the Upper Rhine Region and contributes to knowledge transfer across disciplines, sectors and borders. EURIdoc unites 50 researchers recognised for their excellence in immunology research, their engagement in health and in translating discoveries to concrete applications. EURIdoc benefits from the expertise of Eucor’s doctoral and graduate schools for recruitment and training. It innovates in the supervision of early stage researchers by associating supervisors with cosupervisors and educational mentors form different research institutions and/or sectors. It has access to state-of-the-art technical platforms. It can rely on a well-functioning and dynamic community of immunology researchers, lectures and clinicians. Training sessions for doctoral candidates are organised to provide disciplinary, interdisciplinary, intercultural and intersectorial training. The industrial sector is represented by small medium enterprises and big pharma companies that have committed to provide mentorships, seminars and secondments. Dissemination and outreach strategies include publications in high impact scientific journals, multi-media public communication, participation in citizen science and in patient associations. EURIdoc provides a framework for excellence in research and doctoral training wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Deciphering Glycosphingolipids as Drivers of a Novel Cell-Autonomous Immune Response' under Horizon Europe.

assistant: **Concept**

Pathogens exploit glycosphingolipids (GSLs) on the surface of gut epithelial cells to initiate infection. A recent breakthrough has uncovered a novel, cell-autonomous immune response in which multivalent clustering of GSLs by bacterial toxins or viruses triggers the degradation of the cell polarity protein PARD6B, leading to reduced pathogen uptake. This novel GSL-PARD6B pathway highlights the critical role of GSLs in mucosal immunity. However, the precise molecular mechanisms by which GSL binding initiates this intracellular signaling cascade and the subsequent changes to the host membrane composition are not fully understood. By integrating novel biochemical techniques with my existing skills in GSL-pathogen research, I will: 1)Define the triggering mechanism of the GSL-PARD6B pathway and, 2)Determine the effects of the microbiota and the GSL-PARD6B pathway on plasma membrane composition.This work will reveal how extracellular signals are translated across the plasma membrane to modulate intracellular responses and uncover mechanisms that protect against infection.Overall, the GlycoGuard project intends to provide a comprehensive understanding of the GSL-PARD6B pathway, advancing our knowledge of host-pathogen interactions and paving the way for novel therapeutic strategies against infections. Additionally, this grant will enhance my skills as a researcher and provide the foundation to establish myself as an independent scientist.


**Keywords:** Glycosphingolipids, Host-Pathogen Interactions, Mucosal Immunity, Cellular Signaling Pathways, Nanodomains, Microbiota, Bacterial Toxins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Towards matchbox-size GHz femtosecond lasers for frequency combs generation: ‘a femtosecond laser fabricating a femtosecond laser’', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Femtosecond laser GHz cavity lasers has enabled a new type of optical frequency comb that have defined a new standard and a universal method for precisely measuring optical frequencies measuring. This quantum leap in metrology unravelled numerous technological innovations, from more precise atomic clocks to unprecedented data-transmission flowrate in telecoms. So far, optical frequency-comb systems remain table-top size and expensive, an impediment for further adoptions of this major technological break-through. Here, we propose a novel concept of monolithic, miniaturized – matchbox size - femtosecond laser GHz cavity, in which all the optical functions are integrated in a same substrate, including active functions requiring active tuning or electro-optics effects. This concept relies on femtosecond laser machining combined with post-processing methods to fabricate this optical cavity and to perform the fine alignment required for proper laser operation. It defines a new paradigm where ‘a femtosecond laser is used to fabricate and tune another femtosecond laser’. Specifically, GigaFemto aim at 1/ demonstrating the first all-in-glass femtosecond GHz cavity, of matchbox size, fabricated and tuned by another femtosecond lasers and 2/ laying the seeds for a commercial exploitation by a spin-off company of our laboratory. The later will include a market analysis and a thorough precompetitive study.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'STRUCTURE AND PROPERTIES OF NEW M-Si-Al-O-N OXYNITRIDE GLASS CERAMICS (M=Y,Ln)' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Oxynitride Glass Ceramics are a growing group of new materials which show improved retractoriness and mechanical pertormance compared with the tasks allocated to that laboratory and will he highly trained in the relevant techniques. Also during the three-year project, the fellows will well-estahlished and commercially important oxide glass ceramics. The present project aims to determine crystal structures and measure relevant spend one month in each of the other laboratories, acquiring state-ot-properties for currently uncharacterised new glass-ceramic phases in the-art know-how in the methods used. By the end of the programme, they will have acquired a well-rounded portfolio of expertise in the techniques yttrium and rare earth sialon systems The partners in the consortium are from well-founded research laboratories all with previous experience in the used for the preparation, analysis/characterisation and testing of ceramics. field of nitrogen ceramics Each partner will contribute expertise in one or two techniques towards the overall objective of structure/property determination These materials have interest as refractory grain-boundary phases in Si3N4-hased ceramics, and also as retractory surface coatings (glazes) and as interface materials in nitride-oxide and nitride-metal joints