RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'EUROpean CITIzenship practice: political participation of transnational European senior migrants' in the context of a Seventh Framework call.

assistant: **Objectives**

In the context of European integration and the emergence of a leisure-oriented culture, traditional lifestyles have been replaced by new patterns of behaviour. In this regard, a remarkable phenomenon is the increasing migration of mainly retired Europeans to the coastal regions of the Mediterranean. In the last decade, major changes concerning the social and political participation of such amenity-seeking migrants have been taking place, chiefly triggered by granting EU-foreigners active and passive voting rights in local elections. Given the fact that many of the retired residents belong to the economic elite and were successful professionals, they count on powerful tools, know-how and resources to integrate and take leadership in local politics. Migrants from northern Europe founded their own parties e.g. in many Spanish municipalities and are currently active in the local councils. EURO_CITI is an innovative and interdisciplinary research project dealing with the different forms of political participation of retired European residents and principally aimed at discussing the practice of European Citizenship both in a conceptual and empirical framework.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'uPROPHET: Urinary PROteomics in Predicting HEart Transplantation outcomes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The proof of concept underlying uPROPHET rests on the EPLORE findings that capillary electrophoresis coupled with high-resolution mass-spectroscopy reproducibly identified unique urinary proteomic (UP) signatures associated with subclinical left ventricular dysfunction, renal impairment and adverse cardiovascular outcomes. Consensus criteria currently applied for the selection of patients for heart transplantation (HTx) leave an inconvenient margin of uncertainty, because of the unpredictable course of the disease and the shortage of donor hearts. Furthermore, monitoring graft function and adjusting immunosuppression remain major challenges after HTx. Endomyocardial biopsies, up to 20 in the first year after HTx, are the standard approach to detect graft rejection, but require an invasive risk-carrying procedure. uPROPHET aims to develop UP profiling: (1) as a prognostic tool helpful in selecting terminally ill heart failure patients for HTx with the greatest probability of survival while adding a maximum of high-quality years to life; and (2) as an instrument to monitor graft performance and immune system activity and to manage immunosuppression. The new UP classifiers will be initially validated by demonstrating analogy between the proteomic profiles in urine and tissue samples of explanted hearts. uPROPHET will show case the translation of state-of-the-art technology into “innovative services”, broaden the indications for UP, and therefore have a major impact on the plans of the business partner measuring the UP profiles. The evident benefit for the customer (patient) is the early and non-invasive stratification of risk in heart failure patients before and after HTx, hence allowing an early, personalised, and targeted approach. Clinical implementation of uPROPHET fin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Changes in the geomagnetic dipole (Earth Dipole Field Intensity from Cosmogenic Elements)' (EDIFICE).

assistant: **Innovation**

Ancient records of the geomagnetic field intensity provide the unique source of information on the evolution of the geodynamo. The paleomagnetic data contain a broad spectrum of dipole moment fluctuations with polarity reversals and excursions that typically occur during periods of very low field intensity, but the amplitude and the timing of the variations as well as critical features remain debated. The variability of the dipole with rapid fluctuations combined with long-term changes must be clarified to understand what controls the dipole strength, why it fluctuates and what is the cause of polarity reversals. Much has been learned for the past 30 years from records of paleointensity relying on natural remanent magnetization of sediments and lava flows, but large uncertainties persist and major features of the field remain poorly documented, pointing out the limits of the approach. As an alternative to magnetization, changes in geomagnetic intensity can be reconstructed from the production of cosmogenic 10Be. The 10Be production can be measured with confidence from sedimentary sequences. Our main objective is to build up a worldwide database of the dipole field changes for the past 5 Ma by acquiring high resolution records of 10Be production from a worldwide set of selected sediment cores. The Accelerator mass spectrometry national facility « ASTER» at CEREGE dedicated to 10Be measurements offers this unique opportunity.  Accurate time control will be obtained by astronomical calibration of paleoenvironmental records. In parallel, we will focus on the short-term field changes occurring during geomagnetic reversals. This will be addressed by combining detailed paleomagnetic records of reversals from volcanic sequences with high resolution 10Be measurements from marine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Molecular characterization of gabaa and glutamate receptors in rat hippo- campus during aging. Subunits quantification by competitive pc and rna editing analysis' to be submitted under Fourth Framework.

assistant: **Abstract**

The objective of the present project is to determine the possible changes in the subunit composition of the two major neurotransmitter systems in rat hippocam- pus during aging. The interest of this study is based on hypothesis that modifica- tions observed in some pharmacological properties of GABAA and Glutamate receptors during aging, could be explained by aged-related modifications in the molecular composition of these receptors. In turn, this potential alterations could explain, in part, the aged-related modifications in the learning capacity, memory and sensitivity to benzodiazepines. The different subunits corresponding to the GABAA and Glutamate receptors will be quantified by competitive polymerase chain reaction (c-PCR) with the inclusion of internal standars. Aged-related increase in the ex- pression of the alpha-1 subunit, in combination with a switch in the expression of the gamma subunits of the GABAA receptor in rat hippocampus are expected. As a se- cond goal, the potential aged-related modification of RNA editing in the GluR2, GluR5 and GluR6 glutamate receptor subunits will be analyzed. The RNA editing has been proposed to control the calcium permeability and the rectification properties of the channels.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ethological and neurobiological apects of associative olfactory learning in moths' in the context of a Fourth Framework call.

assistant: **Objectives**

Insects are often imagined as totally dependent on innate behaviours. However learning capabiiity has been demonstrated in a number of insects. In the present application, I suggest to study learning processes in moths. Moths offers a very attractive model system for the study of associative learning, as several, behavioural relevant odours are known and the neural elements involved are very accesible for neurological studies. Both I and the group of my host research supervisor have shown in preliminary experiments that moths are indeed capable of learning to associate a flower odour with a food reward. Now I want to extend the behavioural studies and parallely I want to perform neurobiological investigations of neural elements involved in the formation of odour induced associative learning.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Exploring the evolution of protein-protein interactions and their networks using biophysical models' (EEPPIBM) targeting Seventh Framework.

assistant: **Abstract**

The evolution of protein interactions has produced interaction networks and much biological complexity. Although molecular phylogenetics reveals the end points of evolutionary searches, little is known about the trajectories of interacting proteins through sequence space over evolutionary time. A major bottleneck is the inability to extensively map how binding affinity changes with sequence. A previously developed affinity prediction model will be modified to predict affinity changes upon mutation. Preliminary results show that this method has unprecedented speed and accuracy. In the proposed research, the preliminary models will be improved and thoroughly validated. Subsequently, they shall be used to assess millions of combinations of interface mutations in structurally annotated interaction networks. The mutational robustness of interactions will be determined, compared with theoretical models, and its relationships with observed evolutionary rates investigated at the amino acid, interface, protein and network levels. Then, paths connecting orthologs to each other and to ancestral protein reconstructions will be determined and characterised. The positions on the phylogenetic trees where the affinity imbuing contacts are gained will be determined, as well as the positions where interactions are lost, revealing network rewiring. This will illuminate the changes in interactions over time, and show how interface biophysics constrains the functionally viable paths available for interaction evolution. The relationships between extent of constraint, evolutionary rates and network properties will be investigated. We hypothesise that the inherent ability to form interactions and modulate specificity can explain a number of observations garnered from network evolution studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'From Black Holes to Ultra-High Energy Cosmic Rays: Exploring the Extremes of the Universe with Low-Frequency Radio Interferometry' under Seventh Framework.

assistant: **Concept**

Black holes (BHs) and ultra-high energy cosmic rays (UHECRs) are two extremes of the universe that link particle physics and astrophysics. BHs are the most efficient power generators in the universe while UHECRs are the most energetic particles ever detected. As we showed previously, a major fraction of the power of BHs is channeled into radio-emitting plasma jets, which are also efficient particle accelerators. Are BHs also responsible for UHECRs? This long-standing question could be answered soon, through the dawn of cosmic ray astronomy. The giant Auger observatory has now shown for the first time that the arrival directions of UHECRs are non-isotropic, potentially pointing back to their sources of origin. BHs turned out to be major suspects, but other sources could still also be responsible. To address this conclusively and to establish cosmic ray astronomy as a productive new field in the coming years, we need to increase statistics, expand current observatories, and have complementary all-sky radio surveys available to identify sources, since radio emission traces particle acceleration sites. Here, techniques pioneered by the Low-Frequency Array (LOFAR) promise major advances. First of all, working on LOFAR we uncovered a new technique to detect UHECRs with radio antennas and verified it experimentally. The technique promises to increase the number of high-quality events by almost an order of magnitude and provides much improved energy and direction resolution. We now want to implement this technique in Auger, combining LOFAR and AUGER know-how. Secondly, LOFAR and soon other SKA pathfinders will significantly improve all-sky radio surveys with high sensitivity, resolution, and image quality. Hence, we will use LOFAR to understand the astrophysics of UHECR source
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'X-ray-induced fluidization: a non-equilibrium pathway to reach glasses at the extremes of their stability range.' (GLAXES) targeting Horizon Europe.

assistant: **Abstract**

I will address the fundamental question of what exactly are and how to prepare glasses at the extremes of their stability range: ultra-stable, ideal glasses on the one side and ultra-unstable, defect-saturated glasses on the opposite side. The ideal glass, predicted by some theories of the glass-transition but not yet observed, is a novel equilibrium state of matter characterized by a fairly unique, dense atomic structure with almost no defects. The defect-saturated glass is instead ductile, at odds with conventional glasses: any additional defect self-heals. I will reach these extraordinary states employing a non-thermal fluidization route activated by X-ray irradiation. Its non-equilibrium nature is key here: conventional thermal treatments, that induce structural changes stabilized by quenching, modify the properties of glasses only over a limited range. My project aims then at:1. producing ideal and defect-saturated glasses;2. developing a general scheme to control the stability of glasses;3. establishing experimentally the connection between their thermodynamic properties and their density of defects;4. clarifying the microscopic mechanism of X-ray induced fluidization;5. describing the glass-specificity of this effect in terms of amorphous plasticity.The importance of these extreme glasses is however not only fundamental: the reduced (zero?) density of defects makes the ideal glass mechanically and optically loss-free; a defect-saturated glass, instead, deforms under load and crystallizes very rapidly. Their properties are therefore enabling for new technological applications ranging from noise-free mechanical resonators, superconducting qubits with sufficient coherence for quantum computers and phase-change materials for applications as memories.The long-term vis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Automated Glycosaminoglycan Synthesis to Access Defined Oligosaccharides for Diagnostic and Therapeutic Applications'.

assistant: **Innovation**

Glycosaminoglycans (GAGs) are biomolecules that have been used clinically for many years. Best known is heparin that has served as an anticoagulant in the clinic for more than 60 years. Defined GAG oligosaccharides are key to establish defined structure-activity relationships for specific interactions with proteins as a first step to modulate processes underlying viral entry, angiogenesis and diseases of the central nervous system.Work funded by an ongoing ERC Advanced Grant has resulted in a synthesis process that can be executed on a fully automated GAG synthesizer. Using this process, defined GAG oligosaccharides representing heparin and chondroitin sulfate, can now be prepared in days rather than months or years.The overall goal of the proof-of-concept project is to establish a differentiated business model for a company that will focus on that will oversee the creation of an automated GAG synthesizer, the building blocks needed to feed the instrument and the production processes of defined GAG oligosaccharides or a combination of these three areas. As a result, it will help to define the market potential for the use of complex glycans on microarrays and as tools for next generation diagnostic and therapeutic applications. The specific activities include: 1) Development of a specification for the automated GAG synthesizer as a commercial instrument; 2) Plan the production of monosaccharide building blocks and establish a cost structure; 3) Plan the production of defined GAG oligosaccharides and establish a cost structure; 4) Analysis of the IP space and development of an IP strategy; 5) Establish a basis for commercial discussion with potential customers; 6) Prepare a business plan for discussions with investors; 7) Incorporate a company to commercialize one or all
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Raman spectroscopy for early diagnosis of oral pre-cancer and cancer using minimally invasive samples' (RAMAN-Dx).

assistant: **Concept**

The Experienced Researcher (ER), Dr Amuthachelvi Daniel, who is at the centre of this application, will, through this MSCA Fellowship, enhance her research and innovation potential through advanced training and international and inter-sectoral mobility. RAMAN-Dx will develop methods for detecting pre-malignant oral lesions using Raman spectroscopy of minimally invasive exfoliated cell and saliva samples.  The ER’s skills in instrument and software development and patient testing will complement the expertise of the host laboratory, Radiation and Environmental Science Centre (RESC) at Dublin Institute of Technology (DIT), led by Prof. Fiona Lyng.  The ER will receive both research and professional development and leadership training and will undertake a secondment at VTT Technical Research Centre of Finland Ltd which will facilitate her career goal to become a world leading researcher in the field of biophotonics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'VISIONS-OLYMPICS. The next generation products and procedures for Vessels and Floating Structures' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

VISIONS-OLYMPICS will aim to increase the European competitive advantage by tapping into the unspoiled/unbiased creative minds of the young generation. It will:â€¢ Offer out of the box concepts and ideas for the future of European maritime transport,â€¢ Develop these ideas within an environment where purpose driven innovation is cultivated and performed in a risk free environment,â€¢ Build bridges between universities and industry,â€¢ Enhance the skills of future employees in a highly competitive environment,â€¢ Offer targeted dissemination to industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hot Spin Electronic Active Magnetic Sensors for Automotive, Data-Storage and Mechanical Engineering Applications' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The world market for automotive sensors currently stands at 3 Billion ECU and, growing at over 10% per year, is projected to be worth 8.5 Billion ECU by 2004. The key drivers behind this growth include: the need for improved internal combustion engine management to reduce automotive emissions, braking and anti skid systems and safety devices, drive by wire control systems etc. Coupled with this increase in demand for sensors is an urgent need for improved sensor performance in terms of sensitivity (higher output levels), stability (especially to changes in temperature) and reliability (including immunity to electromagnetic interference and few if any moving parts). Some types of magnetic sensors offer particular advantages over other types and this Basic Research project will further develop the new European discoveries in Hot Spin Electronics to meet these demands. Building off the discovery of Giant Magnetoresistance in 1988 by one of the partners and the more recent invention of the spin valve in 1990 and the Electronic Spin Transistor (1995), by two other partners, this project will develop a series of new transistor/sensor designs through to proof of concept. Seven leading academic laboratories and two major electronics companies will combine their state of the art techniques and know how in advanced materials development, characterisation. measurement, and microelectronics. The project will pave the way for establishing Hot Spin Electronic Active Magnetic Sensors (HotSEAMS) in the market place by delivering new advances in the necessary materials technologies, establishing the experimental basis and theoretical understanding of Hot Spin Electronics and by developing a number of different device designs. The main focus of the work will be the development of magneti