RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Toolprep cost effective design and manufacture of tools and dies' (1994-1998).

assistant: **Concept**

It is the objective of the proposed research to enhance productivity in tool and die shops and similar production environments where modern CNC controlled machine tools are used in one-of-a-kind production of complex components. Productivity in such shops is often hampered by too long machine tool setting times and a rather chaotic planning situation, due to the nature of the production. At the same time the proposed project addresses the product design process. By developing and implementing application software programmes as an addition to the existing production system comprising CAD/CAM, production control packages and CNC machines - it is the intention to create an environment for a cost/effective integrated design/manufacture of tool parts. The target of the cooperative project. forseen in the exploratory award application, is a dramatic reduction of lead times in the entire process of design, work preparation and manufacture. Software packages to be developed comprize: I) a classification system to classify individual parts of a mould or die according to its production-related features, 2) a production planning and scheduling system for tool makers, based upon a classification of the components in a mould, 3) an integration of the above svstem in the t,vphical IT-environment of a tool shop and 4) a technological planning and information system that will provide optimum inforrnation and service to the machine tool operator. The project is proposed by 6 SMEs, all tool makers, rrom DK, DE, BE, Fl, ES and Slovenia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ecological response to environmental change during Boreal mass extinctions: past, present, and future?""', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The UN is discussing a system of governance of the world’s oceans, amid fears of marine extinction. The greatest threats are warming, oxygen depletion, acidification, and eutrophication. But what does Earth’s past reveal about its future? Parallels can be drawn with the Middle and end-Permian, and Triassic-Jurassic extinctions, in which all aforementioned stresses are implicated. Intense research has revealed much about biotic response to stress but most knowledge derives from the tropics, where the most diverse communities lived. Far less is known about Boreal latitudes. The future of such settings is uncertain, as models struggle to predict what the rate and consequence of change will be near the poles. Are Boreal communities among the most, or least threatened? Earth is usually capable of regulating its climate, but did positive feedback between climate change and biogeochemical cycles reach “tipping points” such that past extinctions were inevitable? Could this happen again? Have Boreal faunas and floras suffered more, or less than tropical counterparts in the past? Are they more, or less at risk now? This project tests the Boreal response to environmental change in three mass extinctions between 260-200 million years ago. Were these communities adapted to stressful conditions and fare better than their tropical counterparts? Or did their niche adaptation leave them susceptible? Extinction patterns and concurrent environmental conditions will be ascertained through fieldwork, fossil and geochemical studies of sections in Spitsbergen. Comparison with tropical communities will reveal similarities and differences in response to change. The necessary long-term study of diverse groups and settings is made possible by extensive low-latitude field collections of the applic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Training Network Sustainable Technologies' to be submitted under Horizon 2020.

assistant: **Abstract**

Over the last few decades major efforts have been made to develop innovative food technologies that deliver safe, nutritious foods with high organoleptic qualities that meet consumer demands. Sustainable technologies such as Pulsed Electric Field, Ultrasound, Non-Thermal Plasma and High Hydrostatic Pressure offer consumer benefits like clean label food products and solutions to anti-microbial resistance. Nevertheless, their application is currently limited in the food industry. Some key technical blockers of wider application include the narrow range of product applications realized, variability in antimicrobial effects and engineering challenges related to upscaling. Additionally, consumer acceptance is currently low. TRANSIT brings together 13 participating organisations from 8 European countries to offer the necessary interdisciplinary and intersectoral training to the next generation of scientists to optimize and drive utility of these sustainable technologies in the food industry. Participants’ expertise at the interfaces of microbiology, process technology, cost benefit analyses, risk assessment and consumer sciences will provide comprehensive training to ten ESRs. Using a functional genomics approach, TRANSIT will identify the main microbial molecular targets in five model species that represent major food associated pathogens and spoilage organisms and will design effective antimicrobial impact strategies for the non-thermal technologies accordingly. In concert with renowned industrial partners, the product range for application will be extended and upscaling of the equipment will be realised. Importantly consumer acceptance studies will be used to support broader product application of the optimized technologies in the food industry. TRANSIT will nurture succes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Personsalised Medicine Innovation through Digital Enterprise Solutions'.

assistant: **Innovation**

It is the aim of PERMIDES to strenghten the competitiveness and foster the innovation potential of Personalized Medicine as an Emerging Industry in Europe by providing key solutions for the reconfiguration of the biopharmaceutical value chain towards a Health Economy 4.0 with a special focus on oncology (i.e. cancer treatment). Current value chain challenges lie in e.g. data gathering and exchange, big data and machine learning, or new software-based marketing methods based.Via a cross-clustering approach, leading biopharma and IT clusters from three countries (Austria, Germany and Norway) will create novel cross-sectoral collaborations between SMEs to address innovation barriers in the biopharma sector via cutting-edge IT solutions. As a cross-cutting industry, the ICT and software sector is an enabler of innovation in many industries and therefore provides a broad knowledge base of processes and best practice solutions in diverse industrial contexts and business environments. PERMIDES will create an collaboration space consisting of workshops, a semantic online matchmaking portal complemented by matchmaking events that will allow biopharma enterprises to identify the most suitable ICT company from the participating clusters. In a second step, the biopharmaceutical SME and the ICT partner will jointly tackle an innovation barrier in the value chain using an innovation voucher scheme. Follow-up coaching and transfer activites by the cluster organisations will maximise the effect of around 90 collaborative projects that PERMIDES aims to achieve.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cell-type Specific Mechanisms and Functional Consequences of Altered NMDA Receptor Development and Mecp2 Deficiency on Developing Cortical Circuits' (NMDARETT) under Horizon 2020.

assistant: **Objectives**

NMDA receptor (NMDAR) dysfunction has been identified in multiple genetic causes of autism and related neurodevelopmental disorders. I recently showed that loss of Mecp2, the cause of Rett syndrome and some cases of autism, differentially affects NMDAR development at cortical synapses on specific cell-types: slowing down the development in excitatory pyramidal neurons and accelerating the maturation in parvalbumin-positive (PV) inhibitory interneurons. Genetic manipulation of NMDAR expression in Mecp2-deficient mice rescued both cortical function and the premature NMDAR maturation in PV cells. Based on these findings, I hypothesize that this cell-type specific disruption of NMDAR development leads to an imbalance in excitation and inhibition in the developing cortical circuits.  To test this idea, I will combine single cell genomic and cell-type specific recording techniques to elucidate how Mecp2 controls the development of synaptic receptors and the impact on network function. In Aim 1, I will use cutting-edge techniques for single-cell RNA sequencing and synaptic recordings of NMDAR maturation in cortical cultures to identify novel cell-type specific mechanisms underlying NMDAR development and the regulation by Mecp2. In Aim 2, I will investigate the functional effects of Mecp2 deficiency and altered NMDAR maturation on the development of cortical network activity using two-photon calcium imaging and multi-electrode array (MEA) recordings. As a neuroscientist and neurologist, this training will prepare me for an independent research career addressing the circuit-based defects underlying Rett syndrome and autism. I have the full support of the University of Cambridge and Wellcome Trust Sanger Institute for the proposed research and my career development. This study wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High throughput molecular diagnostics in individual patients for genetic diseases with heterogeneous clinical presentation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Since the sequencing of the human genome has been completed the demand for genetic analysis in the human health care system is drastically increasing, and the extension of molecular genetic diagnostics is urgently needed. However, the majority of genetic diseases is molecularly and clinically highly heterogeneous, and until recently the available techniques lacked the required capacity to analyze several genes in parallel. The recently introduced high-throughput whole genome sequencing (WGS) technology now offers the unique opportunity to extend molecular genetic analysis by introducing these techniques, and develop taylormade medical resequencing approaches for molecular genetic diagnosis of heterogeneous disorders. This project aims to deliver crucial innovations leading to these approaches, and to deliver a proof-of-principle for its implementation in selected model disorders. The model disorders have been selected with increasing genetic complexity, and represent the majority of non-multifactorial genetic disorders. The current momentum to perform these innovations by a European consortium of clinical genetic diagnostic laboratories and research laboratories and industrial stakeholders will lead to a front-running position of European laboratories and small and medium enterprises (SMEs) in this field. The consortium putting forward this proposal consists of leading scientists and established laboratories providing cutting edge knowledge with respect to quality management aspects, ethical and societal issues, and cost effectiveness issues. This is the only approach that will warrant the development of diagnostic tools designed to restrict genetic testing to relevant medical factors. For European SMEs this proposal offers the  opportunity to identify niches in the ste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Public Participation in Urban Environmental Health Services : A Concerted Action for Sub-Saharan Africa' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

* Improve the effectiveness of research methods and techniques to collect and analyse indicators that correlate i) people's state of physical health, ii) the conditions in their living environment that are risks to their health and iii) the operational status of existing environmental health services in the community.* Enable resource centres working in sub-Saharan Africa to advise Local Authorities in the planning and monitoring of environmental health services in consultation with local residents.Expected Outcome* A better assessment of urban environmental health risks across social strata and African cities through health risk assessments conducted in six different cities.* The transfer of knowledge between partners (on monitoring environmental health risks and facilitating community involvement to plan environmental health services) by defining a set of methodological recommendations such as:- the relevant indicators, to be validated or refined in each location;- sampling procedures;- the structure of a questionnaire survey;- the us of a simple structured observations (such as spot checks);- the use of participatory communication techniques;- relevant physical tests;- what grassroots environmental concerns are to be discussed in focus groups.* One set of procedural guidelines to operationalise community based information centre focusing on urban environmental health and implement site-specific information and communication strategies.* Conduct three workshops, all of them hosted in Africa, two of which will convene researchers from European and African centres, and the third involves researchers from African centres.* Partner institutions will host visiting-researcher(s) from research centres in Africa for a two week internships.* Compile a compendium paper comprise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of Kasuria's code tech product- analytical engine' (2021-2027).

assistant: **Concept**

Kasuria applies data science to blockchain data with a purpose to provide its users (financial institutions/bank/ financial regulators) with clarity on how a specific Decentralized Finance applications generate profit and how risky they are. This data enables the customers to optimally align their own investments in cryptocurrencies and tokens as well as other ""DeFi"" (Decentralized Finance) services. The actual data are quantitative investment metrics using performance and risk indicators that can be calculated retrospectively, i.e. from historical transactions on blockchains, using data analytics. Kasuria's customers need this data for their research and reporting purposes (e.g. for benchmarking or the securities prospectus according to local financial regulatory requirements- such as requested by BaFin in case of Germany) and in particular to be able to quantitatively under- or substantiate the asset selection as part of their own fund and investment strategy.""


**Keywords:** Data Science, Blockchain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Molecular gated Eco-MOFs for anti-cancer drug delivery'.

assistant: **Objectives**

Cancer is a major societal challenge, as reflected by Horizon's Europe mission on cancer and Europe's Beating Cancer Plan. In particular, despite great advances in cancer treatment in recent decades, its treatment still remains a challenge without an effective cure. In 2020 the EU reported around 3 million new cancer cases and more than 1.2 million deaths, and its incidence is expected to increase in Europe due to its aging population. The standard treatment relies on the systemic administration of chemotherapeutics, which has limited efficacy and causes side effects. To overcome current limitations, GateMOF will develop low-toxicity Molecular Organic Frameworks (MOFs) as advanced nanosystems to tackle cancer. Such Eco-MOFs will be equipped with molecular gates and loaded with anticancer drugs resulting in advanced biocompatible nanosystems with the ability to respond to stimuli present in the tumor intracellular/microenvironment for a selective anticancer drug delivery. The project combines the unique expertise of the host laboratory (Supramolecular Chemistry and Biotechnology) and the candidate (MOF design and synthesis) to ensure the fulfillment of objectives. The fellow will be trained in advanced nanomaterial preparation with molecular gates to obtain stimuli-responsive MOFs for anti-cancer drug delivery, including training for biological studies for their evaluation in vitro in cells and in vivo in animal models. Notably, the project will also allow the fellow to gain experience in patenting and tech transfer. Altogether, GateMOF will develop a new therapeutic technology and provide the fellow with complementary scientific and transferable skills with a significant impact toward an independent research career.


**Keywords:** Nanosystems, Nanomedicine, Anti-tumour
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multifunctional Ligands for Enhanced Catalysis' (MLCat) under Horizon Europe.

assistant: **Objectives**

Transition metal-catalyzed C-H functionalization replaces an inert carbon-hydrogen bond with a functional group, expediently altering the properties of the parent molecule to access new classes of compounds. Although the C-H functionalization represents a green chemistry approach as it precludes the need for pre-functionalized starting materials, there are still two main sustainability shortcomings with most current methodologies. The first challenge is achieving functionalization of specific C-H bonds without affecting other C-H sites in the molecule. A widely employed strategy to control the selectivity of metal-catalyzed C-H bond functionalization reactions has relied upon the covalent attachment of directing groups (i.e., pyridine, oxime, diazo) to the parent molecule. The requisite installation and removal of directing groups make the overall transformation less appealing from an atom- and step-economy perspective. The second challenge is to substitute commonly used precious transition metals with more benign earth-abundant alternatives. The proposed research program will address these shortcomings by developing an innovative and more efficient way for selective metal-catalyzed functionalization of aromatic and aliphatic C-H bonds without pre-attaching a directing group. The proposed strategies will rely on the design of multifunctional ligands capable of simultaneous binding to the substrate and the transition metal catalyst. The proposed approach will take advantage of the ability of Cr(0) to form an pi-arene complex and activate the aromatic and benzylic C-H bonds. Addressing these challenges associated with C-H activation technology would have the power to unlock many industrial applications, such as valorizing fine chemicals and modifying complex natural produ