RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dietary Influences on Metastasis: How, When, and Why' (LIPOMET) under Horizon 2020.

assistant: **Objectives**

We have recently identified metastasis-initiating cells (MICs) in several types of tumors (Nature, 2017)1.Intriguingly, MICs: (i) are exclusive in their ability to generate metastases when transplanted; (ii) express thefatty acid channel CD36 and have a unique lipid metabolic signature; (iii) are exquisitely sensitive to thelevels of fat in circulation, thus providing a link between the predisposition of metastasis and dietary fat; (iv)are highly sensitive to CD36 inhibition, which almost completely abolishes their metastatic potential.We still do not know how MICs promote metastasis or how MICs are influenced by dietary fat. Inparticular: (A) where are MICs located within the tumor, and does this location influence their behavior?How and where do they attach and expand at metastatic sites? (B) Why are MICs so sensitive to specificdietary lipids, and how do these lipids promote metastasis at the molecular and cellular levels? (C) Is theprolonged consumption of a high-fat diet a risk factor for developing metastatic tumors? If so, what are theunderlying genetic and epigenetic causes for this effect? Can we revert these causes?To answer these questions, we will combine state-of-the-art in vivo functional models of metastasis, withquantitative metabolomics and proteomics, epigenetic and geographical position (3D) single-celltranscriptomic studies, as well as integrative computational analyses, using preclinical models and patientderivedcarcinomas of melanoma, oral cancer and breast cancer.We expect our project to provide fundamental insights into the mechanisms of metastasis, and how they areinfluenced by diet. This is highly relevant as 1) large quantities of fatty acids are typically consumed inWestern diets; and 2) metastasis is the leading cause of cancer-related death
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'APL a model for oncogene-targeted leukemia cure' under Seventh Framework.

assistant: **Concept**

Acute promyelocytic leukaemia, APL, is probably one of the best-understood malignancies and the only one where highly efficient oncogene-targeted therapies (retinoic acid and arsenic) actually cure the disease. Our recent studies have addressed the molecular basis for transformation and demonstrated the essential role of sumoylation of the PML moiety of PML/RARA, relaxed DNA-binding specificity, binding to RXRA, for both transcriptional repression and transformation in primary cells, uncovering an unexpected level of complexity for in vivo transformation. We have also explored PML nuclear bodies (NB) formation, enigmatic structures that are disrupted by PML/RARA expression, restored by either RA or arsenic and may thus contribute to transformation/response. Exploring the actual basis for therapy response, we have provide some evidence that PML/RARA degradation and loss of leukaemia-initiating cells, rather than differentiation, is key to APL clearance.We propose to address the following issues: i) genetically uncouple differentiation from APL eradication ii) model transformation and therapy response iii) analyse the regulation and role of PML NBs iv) explore other models where degradation of the driving oncogene may eradicate the disease through loss of LIC activity.These studies should not only provide a complete model for APL pathogenesis and treatment response, but also open new avenues in the field of PML nuclear body biogenesis and function, as well as transcriptional activation/degradation coupling. The proposed research could provide generally applicable strategies for a variety of malignancies that are similarly driven by fusion proteins. As previously, in the APL and Adult T cell leukaemia models, our studies could also yield new directly clinically applicable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Where is the water under the Greenland ice sheet?' (WATERUNDERTHEICE) under Seventh Framework.

assistant: **Objectives**

Recent analysis of radar-depth sounder data has shown that many areas of the Greenland ice sheet have melt water under the base. The extent of the wet base and distribution of melt water are poorly known. Also lakes under the ice have not been discovered in contrast with those in Antarctica. The effect of the water beneath the ice, however, is well documented: it lubricates the bed and removes the friction between the basal ice and underlying bedrock. The ice with a wet bed flows faster, reacts rapidly to changes in climate and the basal-melt water contributes to the fresh-water supply to the ocean from the Greenland ice sheet. The primary objectives of the project are to map melt water extent of the Greenland ice sheet and its impact by tracing internal layers and analyzing bedrock returns from airborne radio-echo sounding data, and use mapping results in conjunction with ice-sheet and hydrostatic models for the movement of the basal water to predict the ice-sheet s response to climate change. The information derived from deep ice-cores that reach the bed will be used to constrain models. We will also study the basal material (dust, DNA and microbiological material) and bedrock properties from the deep-ice core sites. This will add a further dimension to the study and provide opportunities to look for life under the ice and constrain the age of the Greenland ice sheet. The proposed research is a high risk project because of the difficulty in accessing basal conditions under 3-km of ice with a potential for high payoff science. The team will consist of scientists and engineers with expertise in the palaeoclimate, radar sounding and signal processing, and ice-sheet models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Global change and subsistence management in Southern African resource variability, access and use in relation to rural livelihoods and welfare' (1994-1998).

assistant: **Innovation**

* To determine how rangeland state influences the components of rangeland productivity (including agropastoral production).* To determine how the components of rangeland productivity contribute to the welfare of rural communities.* To assess the impacts of current policies and practices (at scales ranging from the household to the international) on resource access and use by different groups within the rural community and their welfare.* To assess, as far as possible, the impacts of the variability in biophysical process and socio-economic influences on rangeland state, rangeland productivity and human welfare.* To collate and evaluate the data, derived models and relevant hypotheses, and develop policy and intervention options designed to optimise human welfare and sustainable rangeland use.* To make preliminary estimates of the dynamics of the impacts of human-induced global changes on rangeland productivity and rural welfare.Expected OutcomeOverall the project will lead to the modelling of the dynamic interaction outlined above, to policy recommendations and options, potential physical interventions and possibly, financial priorities designed to improve the sustainability (ecological, economic & social) of the subsistence rangeland in southern Africa. It will enable regional assessment and longer-term planning in the region to prepare for & anticipate potential impacts of global change. It will identify the major elements in the relationships between rangeland state and rangeland productivity. Specific opportunities to improve the management of the rangeland to increase their biophysical sustainability will be identified as will the contribution of socio-economic development of the specific communities.The key activities have been divided into workpackages and includ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The formation, preservation and lithification of low viscosity magma pyroclasts' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The fragmentation mechanisms of low viscosity magmas such as kimberlite and carbonatite remain enigmatic despite comprehensive research on their more silicious counterparts. In order to understand how and why they erupt we must look at their pyroclastic deposits. The little that is known about the fragmentation of these low-viscosity magmas suggests that they behave differently to the higher viscosity magmas such as basalts and rhyolites, implying there may be something unique about the physical properties of kimberlites and carbonatites such as their low silica and high volatile contents. Some basaltic pyroclasts show affinities with kimberlite pyroclasts suggesting there may be a continuum of fragmentation styles related to changes in viscosity of the magma. This research proposal seeks to fill that gap in our current knowledge by establishing the spectrum of pyroclast types and unique parameters of the explosive eruption of ultra-low viscosity magma. In order to fill this gap in our knowledge I propose to investigate the pyroclast morphologies of kimberlite using a world class collection housed at the University of British Columbia. I then intend to gather a range of moderate to low viscosity pyroclasts from Hawaiian basalts and Italian carbonatites and compare and contrast the range of pyroclasts found. On establishing that there is a range of pyroclast shapes and internal morphologies developed by the different magma types I propose a series of analogue experiments, undertaken at Bristol University, to attempt to recreate the range of pyroclast morphologies observed in nature and assess the physical properties of the magma that influence the formation of the different styles of pyroclasts. The proposed research will not only fill a significant gap in knowledge but
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Legacy assessment workbench' (LAW).

assistant: **Innovation**

The LAW project will perform a study to prove the feasibility of a workbench combining existing tools and new developments to enable efficient and economic analysis and assessment of legacy systems.The objectives are to assess users requirements and to prove concepts by developing prototypes and demonstrating usability on selected case studies (also in terms of performance and scalability for industrial use).The future LAW workbench will support maintenance and evolution of existing applications as well as certification and reuse of software.This workbench will offer tools for source code analysis with various goals:- Syntax and structure analysis to extract information and allow efficient search and navigation.- Metrics measurement and programming standards checking to evaluate the quality of the software and contribute to its certification.- Semantic analysis to help the understanding, validation or evolution of the application.- Temporal analysis to highlight temporal characteristics of the software and deduce temporal constraints to support maintenance and migration.In addition to the classical techniques providing information on the architecture of the application and the structure of the programming units, the user will be able to apply advanced techniques such as property synthesis, proof obligation generation, symbolic execution, weakest precondition computation, theorem proving and constraint satisfaction.The most important feature of the LAW workbench will be the mixing of the above techniques in an integrated and user-friendly workbench.The workbench will be used for all kinds of legacy systems. However it will be particularly useful for safety-critical applications for which compliance with standards and certification are essential.The feasibility study will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Bose-Einstein Condensate of Heteronuclear molecules - creation and spectroscopy of Li-Sr BEC' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

We propose to achieve the creation of a two-species molecular Bose Einstein condensate, consisting of fermionic Li and Sr. The project will be conducted in the Ultracold group at the university of Innsbruck, under the supervision of Prof. Rudi Grimm.The molecular system is a promising candidate for the study of new physics with ultracold heteronuclear molecules. Especially interesting is their Bose condensation, since the high mass ratio, as well as their dipolar properties, allows manipulation of the interaction strengths. On the other hand, laser-cooled alkaline-earth atoms are stimulating a growing interest in the field of atom physics.Quantum degeneracy of alkaline-earth atoms has not been achieved so far and appears as a motivating goal for experiment s with Sr. The project is a logical next step in the current state of the art research in ultracold molecular physics, and opens a great deal of new directions. The creation of heteronuclear molecular Bose condensates gives the premises for an unprecedented opportunity to investigate chemical physics and high-resolution spectroscopy of coherent molecular systems.For the applicant, the project will lead to a collection of experience in the fields of cooling and trapping of atoms and molecules, as well as expertise in the state of the art methods for molecular BEC formation. The long-term goal is to investigate coherent control of molecular reactions in ultracold systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Agent based brokerage service in electronic commerce' (ABROSE).

assistant: **Innovation**

Main ObjectiveABROSE aims to create an agent based brokerage service. The main objectives of the project are to:  -design, implement and integrate the ABROSE system, relying on an existing agent platform, and incorporating the main features: 1.dynamic knowledge capture, 2.multi agent system for knowledge representation, 3.user agent support for requests and navigation, 4.provider agent support for offer registration and propagation and 5.improving the performance and the quality of mediation through usage of collaborative adaptive agents.  -verify, demonstrate and evaluate, the technical and economic suitability of multi-agent technology for commercial applications,  -demonstrate how agent technology helps to create customisable and adaptive applications in the information brokerage domain,  -evaluate the projects results, provide recommendations of refinements and enhancements for Multi Agent Facilities, to the relevant standard fora such as OMG MAF and especially FIPA. Technical ApproachABROSE takes into account the results from the AC206(ABS) and AC230 (COBRA) projects, relying on existing models for the Brokerage Service. ABROSE will include:  -the final design and implementation of the agent based architecture .  -international demonstrators and  -an accompanying evaluation. Summary of TrialABROSE will demonstrate its system at two different European sites. One of these is the FT/BATRU Lannion site, the other is the Onyx site, which is TCP/IP based and publicly available. ABROSE will apply the system in two different domains: Tourism: Degriftour, an electronic travel agency, will apply the system to offer customers a remote service and to allow providers to promote special offers to their customers. The demonstration plans to allow test users to access a travel age
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dose reconstruction for workers of Mayak and for Techa riverside residents' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Foreseen ResultsThe existing dosimetry systems will be improved : the film dosimetry system of Mayak by studying the energy dependence of the film sensitivity and by taking into account the spectral properties of the radiation fields at the working places, the dosimetry system of URCRM with the help of radionuclide transport in the Techa river and the radiation transport with the help of luminescence analysis of bricks, ceramics and sediments. Results of the different methods will be compared to achieve the objectives.The Production Association Mayak in Osjorsk (former Cheljabinsk 65) started the operations of the first Soviet industrial nuclear reactor in June 1948. In the same year, a radiochemical reprocessing plant for irradiated fuel was opened. Due to the absence of the necessary professional experience and due to the haste because of the military competition with the US, workers in both facilities received high radiation doses during the first years of operation. Annual individual doses reached up to 4 Sv with maximal total individual doses of up to 10 Sv. These radiation exposures resulted in health effects. Beginning from the middle of the 1950's, the personnel was medically surveyed by Branch 1 of the Biophysical Institute of the Health Department.Techa riverside residents were mainly exposed due to the radioactive liquid discharges of Mayak with a total activity of 2.7-106 Ci during the period 1949 to 1956. Internal exposures occurred due to ingestion of radionuclides with drinking water and due to the use of the Techa river water for irrigation. Inhabitants of the upper techa riverside settlements received high external exposures from the contaminated river sediments. Among the population cases of chronic radiation sickness and a significant increase of leuk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Quantum optics with microwave photons building a tool-box based on superconducting technology'.

assistant: **Concept**

The research proposed in this application has grown out of the research on solid-state qubits, where a superconducting circuit including Josephson junctions can be made into a quantum-coherent, two-level system, an artificial atom. It has recently been shown that these artificial atoms can be integrated with microwave cavities in such a way that the states of the atom" can communicate in a quantum coherent way with individual photons in the cavity. This opens up an opportunity to engineer quantum system utilizing both the atom and the photon degree of freedom. There are three essential features in this proposal, circuit-QED, tunable Josephson elements and the possibility to integrate many qubits and many cavities on the same chip. The overall objective of this proposal is to build a toolbox based on circuit-QED and tunable superconducting elements, to enable on-chip integrated quantum optics. Our vision is to move quantum optics experiments from large optical tables and integrate them on chip, with a substantially increased level of integration. Working in the microwave domain, we have the following specific objectives: " An on-demand single photon source " A number resolving single photon click detector " A single photon router " A single photon sluice " A linear quantum limited parametric amplifier " Demonstration of the dynamical Casimir effect"