RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The detection of UV B damage and characterisation of its biological consequences in the cellular components of human skin.' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The objective of this study is to obtain an understanding of the fundamental cellular mechanisms underlying the biological effects of human exposure of UV-B and sunlight.The project is a continuation of an existing highly successful collaboration (EV5V-CT91-0034) whose aim was to obtain a proper understanding of the fundamental mechanisms underlying the biological effects of human exposure to UV-B and sunlight. We will provide information on the activity of UV-B in the initiation step (via lethality, clastogenicity and mutability) and the promotional step (via immunomodulation and altered gene expression) of carcinogenesis. We will concentrate our studies on the in vitro response of cells derived from human skin to calibrated UV-B sources and natural sunlight. Subsequent studies will attempt to corroborate laboratory results with investigations on intact skin samples and ultimately on human volunteers. The experimental approach is based upon procedures which have proved successful in the present collaboration: (1) We will characterise the response of different cell types from human skin. (2) We will exploit our extensive resource of cells obtained from DNA repair defective donors. (3) We will utilise new and existing monoclonal antibodies to DNA damage to resolve the significance of specific lesions in studies of the lethality, mutagenicity and clastogenicity of UV-B. (4) We will resolve the contribution of UV-B to immunomodulation by a study of adhesion molecules and extend our study to altered gene expression. (5) We will provide methods to assess individual exposure. The programme of research is thus designed to provide a balance sheet of UV-B damage, its repair, and its effects on gene expression in human skin. From this balance sheet it may be possible to resolve t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The socio-economic role of domestic service as a factor of european identity' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

It was long expected that domestic service would disappear, that technological progress would eliminate it. Today, recourse to domestic help is still frequent. Their number is perhaps even increasing, due a wide range of reasons: current changes in labour organisation, including women's increasing presence in the labour market, increasing number of people living alone requiring domestic help, especially the elderly, growing immigration to EC from less favoured areas. Interest already exists in the European servant population of the past. This population represented about a fourth of the young generation, and about 10% of total population. Servants were the most mobile element and were major actors in changing mentalities. Creating development models for such a social group would not only shed new light on European social change in past centuries, but would also offer long term interpretation schemes to better understand the present.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Euro mod epr' (1998-2002).

assistant: **Concept**

This application is for a Euro summer school on modern Electron-Paramagnetic Resonance (EPR) spectroscopy. EPR is the most effective tool for structural and dynamical characterization of paramagnetic substances. It is used in a broad range of research fields such as stable and transient free radicals, metalloproteins and metalloenzyms, radiation damage in DNA, heterogeneous catalysis, new materials, nanostructures, semi-conductors, and excited states. EPR spectroscopy is also very active in the areas of complex fluids, self-assembled systems, membranes and proteins, are investigated through the introduction of spin-labels. With the recent exciting advances in the Human Genome Project it is expected that EPR spectroscopy will play a significant role in the characterization of the structure and function of metal sites in new proteins and in enzymatic reactions involving radicals. EPR spectroscopy has witnessed during the last 15 years tremendous methodological and instrumental developments primarily in the directions of high field EPR and pulsed EPR.These include multi-frequency, multi-resonance and multi-dimensional experiments, in the spirit of the developments that revolutionized the field ofNMR spectroscopy. These advances increase considerably the information content of EPR measurements and have therefore impacted various areas of chemistry, materials, physics and biology. The objectives of the school are to disseminate modern EPR methodology to the scientific community through its young researchers. It will effectively expose young scientists to the newest methodological and instrumental developments in EPR spectroscopy along with novel research applications, and it will give them the theoretical tools that are essential for the comprehension of the various techniqu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The role of danger signal and cellular competition in the elimination of B cells lacking the B cell receptor.'.

assistant: **Objectives**

B cells represent a specialized population of lymphocytes responsible for adaptive immune responses and life-long immune memory. All mature B cells carry B cell receptors (BCRs) on the surface and it is through the BCR that B cells recognize foreign antigens and subsequently provide antibody responses. Acute ablation of the BCR in resting mature naïve B cells in mice leads to a fast disappearance of Immunoglobulin negative (Ig-) B cells from peripheral lymphoid system. This phenomenon has been mainly explained by a “tonic” signal provided by the BCR, essential for B cell survival. However, there are at least two other possible, not mutually exclusive, mechanisms. In this proposal I hypothesize that i) loss of the BCR structure provides a “danger” signal leading to apoptosis of Ig- B cells; ii) Ig- B cells are eliminated as a result of cellular competition with the Ig+ B cells. I will test these 2 hypothesis by i) addressing the unfolded protein response (UPR) in Ig- B cells as a possible “danger signal” followed by in vivo genetic rescue experiments testing for its causality in Ig- B cell depletion; ii) I will produce pure Ig- B cell cultures, exploiting the novel system of genome editing of primary B cells, and address - in vitro and in vivo - the fitness, proliferation and differentiation capacity of Ig- B cells in presence and absence of cellular competition with Ig+ B cells. By addressing these points my work might provide a first-time evidence for the existence of “a danger signal” initiated in a B cell upon BCR ablation and prove its causality in Ig- B cell disappearance. On the other hand, elimination of Ig- B cells as a result of cellular competition with Ig+ B cells is a novel concept with important implications for lymphoma biology and potential clinical appli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Researchers' Night 2008 Estonia' to be submitted under Seventh Framework.

assistant: **Abstract**

The Reseachers' Night project is dealing with the changes of public attitudes to the science and researchers work. The common public opinion describes scientists as the lonely people working far away from the everyday life in an ""ivory tower"". RNEst08 shows the attractiveness, creativeness and very broad possibilities of this profession - the profession of a scientist and/or researcher.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Chip-level optical interconnects using a glass waveguiding ceiling""'.

assistant: **Concept**

A novel configuration is proposed for chip-level optical interconnects on processors in order to overcome the communications bottleneck" associated with reducing chip feature sizes. An opto-electronic overlay Consisting of opto-electronic Chips bonded to a glass waveguiding "ceiling", links the data launch pads. The lasers and receivers with integrated drive circuitry ensure that chip area on the processor is not compromised. The objective of this project is to fabricate a commercially-viable glass optical "ceiling". Modelling and fabrication trials will investigate the performance of diffractive components defined on glass for coupling of VCSEL lasers to multimode guides and from guides to pin detectors aiming to achieve 25% coupling efficiency for data rates of up to lGb/s. A complete optical ceiling will be designed and fabricated including diffractive couplers, waveguide interconnects, power splitters and interfaces to external fibres, aiming for an interconnection density of 100/cm2."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Protein fragments in molecular recognition and folding pathway' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

One of the strategies used to overcome the cooperativity of protein folding is to study fragments and peptides.We suggest to study the folding of a family of fragments of barstar, an inhibitor of the ribonuclease barnase, corresponding to its progressive elongaiion from the N-terminus. The objective is to study the development of slructure in a small protein, by diseccting it into N-terminal fragments of increasing length. These fragments will be created by cleavage of full length mutant protein for larger peptides and by chemical synthesis for small peptides. The introduction of Met residues by protein engineering will be used as cleavage sites for cyanogen bromide.We will analyze the ability of complementary fragments to associate and form a native-like structure, an association/folding study that could show the docking of preforrned segments, that constituted folding initiation sites. The project would include the construction of small fragments that could mimic the interaction between barnase and barstar.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Formal methods for multi-agents systems' under Sixth Framework.

assistant: **Concept**

The multi-agent paradigm is emerging as a promising new programming approach with the goal of providing computing and communication services to the user on the basis of autonomous component-based processes. One of the major challenges in the multi-agent systems (MAS) area concerns the understanding of coalition and negotiation mechanisms between agents. While MAS has for long been a prominent area of artificial intelligence (AI) which is finding its way to applications, enhancing the quality and reliability of MAS using formal methods is a recent, still under-explored topic. To date, formal methods for MAS suffer from expressiveness limitations, which prevent them to consider anything but very simple properties. This is an interdisciplinary project, at the frontier between theoretical computer science and AI. Its outcome is a new generation of logic-based formal methods for MAS, which will bridge the gap with current AI research.The applicant is an experienced researcher with skills in formal methods; her recent contributions to the field of controller synthesis are the stepping-stone of the proposed project. The highly expressive formalism developed in the control framework will be integrated in the family of logics for MAS, associated with effective methods and tested in realistic contexts like those considered in AI. The host institution is the Computer Sciences Lab of the prestigious Australian National University, which provides a world-class training and research environment in Logic & Computation and Knowledge Representation & Reasoning. Her integration into both groups will enhance the applicant's expertise in pure and applied logic, as well as in AI and MAS applications. Concerning the return phase, the applicant plans to build from her new experience to apply
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'T cell regulation by fed state bacterial metabolites' to be submitted under Horizon Europe.

assistant: **Abstract**

Intestinal microbial communities expand the functional capabilities of the host via their metabolic attributes. From energy harvest to the production of vitamins, the gut microbiota shapes mammalian physiology and is often considered a postnatally developed organ. Yet, the microbiome poses a formidable challenge to the immune system: How can we host trillions of bacteria without mounting an inflammatory response? Gut immune homeostasis relies on the balanced action of suppressive and inflammatory T cell subsets. I discovered that bacterial metabolism of bile acids and dietary fibers promotes the differentiation of suppressive T cells. Given the complexity of the microbiome, finding other immunoregulatory cues deployed by gut bacteria and their mechanisms of action remains a major challenge, and the logic behind these tolerance mechanisms is not understood. I will use a novel conceptual framework to bridge this gap: based on my previous findings, I postulate that immunoregulatory bacterial molecules are produced in response to food intake. Within this emerging paradigm, I selected two new groups of bacterial molecules for immediate investigation and developed a strategy to identify novel putative immunoregulatory candidates based on a careful examination of microbial metabolism after food intake. I will find the molecular targets of active molecules using chemical screening and chemoproteomic methods and test metabolites in vivo by colonizing germ-free mice with genetically manipulated bacterial strains. The proposed work is grounded on my strong expertise in host-microbe interactions and takes advantage of the state-of-the-art biochemistry facilities at my hosting institution and of the complementary skillsets of my collaboration network. This synergistic combination wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Subcutaneous delivery of theranostic cell-based therapies' to be submitted under Horizon Europe.

assistant: **Abstract**

This PoC project seeks to develop a simple-to-implement self-assembled and injectable hydrogel material for the controlled co-delivery of our simili-CAR NK cells and stimulatory cytokines to improves treatment of both solid and liquid tumors. Similar to biologics delivery where monoclonal antibodies (mAbs) are commonly administered by IV infusion due to regulatory criteria favoring such route which had limited confounding factors, the IV administration remains responsible for some over costs and clinical challenges including the need for dedicated infusion facilities, aseptic preparation of required infusion batches, extended infusion times, potential difficulties and risks with IV catheter. The subcutaneous (SC) administration is deemed to overcome many of these challenges and might appear as an attractive alternative to the IV administration. In addition, the SC route used for mAb administration was received with an overwhelming preference according to patients despite limited and reversible local adverse events induced by the rHuPH20. Alternative solutions are being evaluated through clinical trials such as the direct SC injection of mAbs without recombinant human hyaluronidase or using novel enzymes but none are currently being clinically-developed for cellular therapies. Moreover, those alternative SC methods induced large pharmacokinetic heterogeneity between patients confirming the need to develop novel alternative approaches to accelerate the development of SC mAbs formulation. Hence, in parallel to the biological approach, chemistry-based approaches, such as hydrogels have been proposed. However, to date, none of them successfully managed to be translated to the clinic; this can be explained by the absence of full biodegradability after injection or/and potenti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Labelling of fusion proteins in living mice with synthetic probes' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Characterizing the movement, interactions and chemical microenvironment of a protein inside the living cell is the key towards a detailed understanding of its function. While in the past most functional studies of proteins have been performed in vitro or with cell culture experiments, it has become increasingly evident that protein function also needs to be studied on an organismal level. To achieve this objective, there is a generally acknowledged need for new and innovative approaches to study individual proteins in living animals. In this project I propose to develop a method for the covalent and specific labelling of fusion proteins in transgenic mice with synthetic probes that allows performing in vivo imaging studies of selected proteins in the living animal.The approach is based on expression of the protein of interest as fusion with mutants of O6-alkylguanine-DNA alkyltransferase and its labelling with synthetic benzylguanine derivatives, a technology that has been developed in the host laboratory for this project and has already been applied to specifically label proteins in cell cultures. Transgenic mice will be generated using the lentivirus technique. In summary, the proposed research aims at the development of new and innovative approaches to study central biological problems and should allow establishing the covalent labelling of fusion proteins in living animals as a key technology in life sciences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Promoting Resilience tO Plant diseaSe: Understanding vulnerability and adaptation to Xylella fastidiosa' (PROPS).

assistant: **Innovation**

Plant health is vital for sustainable development. Plant pathogens threaten economies, food security, and rural livelihoods. Existing plant disease research focuses on ecology, epidemiology, and economic losses. This overlooks social questions such as what makes farmers vulnerable to plant disease and what enables them to adapt. Without this knowledge, it is difficult to develop equitable solutions to manage plant disease. During my MSCA fellowship, I will work with the Laboratory for the Analysis of Social-Ecological Systems in a Globalised World (LASEG) at the Autonomous University of Barcelona. Working with experts on environmental governance and rural wellbeing, I will develop a novel approach to understanding the political ecology of plant disease. My empirical focus is Xylella fastidiosa, an invasive bacteria that is considered the most serious threat to EU plant health in generations. I will conduct fieldwork in two regions of Spain facing an outbreak of XF: the Balearic Islands and the Valencian Community. During preliminary research in these regions in 2019 and 2022, I built a team of stakeholders that includes farmers, government officials, agricultural cooperatives, scientists, and more.  I will 1) use Q-method to map stakeholder perspectives on Xylella governance; 2) interview farmers to understand Xylellas impacts in terms of differential vulnerability and ability to adapt; and 3) conduct participatory Photovoice workshops to engage rural communities in envisioning possible rural futures for living with Xylella. Through a six-month traineeship with the European Food Safety Authority (EFSA), my findings will feed into ongoing science and policy dialogues on Xylella. By foregrounding place-based knowledge, my approach will help inform more equitable plant hea