RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Logics and Algorithms for a Unified Theory of Hyperproperties' (HYPER).

assistant: **Innovation**

The central role of information technology in all aspects of our private and professional lives has led to a fundamental change in the type of program properties we care about.  Up to now, the focus has been on functional correctness; in the future, requirements that reflect our societal values, like privacy, fairness, The central role of information technology in all aspects of our private and professional lives has led to a fundamental change in the type of program properties we care about.  Up to now, the focus has been on functional correctness; in the future, requirements that reflect our societal values, like privacy, fairness, and explainability will be far more important. These properties belong to the class of hyperproperties, which represent sets of sets of execution traces and can therefore specify the relationship between different computations of a reactive system.  Previous work has focussed on individual hyperproperties like noninterference or restricted classes such as k-hypersafety; this project sets out to develop a unified theory for general hyperproperties. We will develop a formal specification language and effective algorithms for logical reasoning, verification, and program synthesis. The central idea is to use the type and alternation structure of the logical quantifiers, ranging from classic first-order and second-order quantification to quantifiers over rich data domains and quantitative operators for statistical analysis, as the fundamental structure that partitions the broad concept of hyperproperties into specific property classes; each particular class is then supported by algorithms that provide a uniform solution for all the properties within the class.  The project will bring the analysis of hyperproperties to the level of traditional no
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A unique radar sensor system to monitor movement and vital signs for elderly people in care homes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Currently, Europe has the greatest percentage of population aged 65 or over (20%). As life expectancy is increasing there isan increasing prevalence of chronic diseases which represents a major challenge for health systems. In fact, total ageingcosts in the EU are projected to reach 28.3% of GDP in 2060. Therefore, there is a huge need of developing innovative andminimally invasive devices for monitoring elderly vital signs parameters and movements in care homes. The golden standardmethods are represented by smart sensors and camera systems. However, they lack in real-time alerting services, theyneed constant physical interaction and have limited measurements capabilities. Raytelligence introduces the RayVS1, asingle radar sensor that can detect position, movement (fall detection), heart and respiration rate of persons in care homeswithout the need of physically interact with the user. The sensor provides real-time and customized alerts to caregivers,medical professionals and family members whenever the signals overcome predefined thresholds, through a dedicatedcloud application. This will ensure wide coverage (multiple people monitored with one sensor) and injury prevention thussaving related healthcare costs. Moreover, it guarantees privacy to the users since personal data are securely stored into thecloud and it ensures high precision and accurate motion measurements (20μm). RayVS1 has already obtained the CE markfor in-home use. During the feasibility assessment, a go-to-market strategy and a supply chain will be established, as well asfurther development plan will be drafted. During the second phase of innovation project, Raytelligence will optimize thesignal processing activity to monitor multiple individuals with one RayVS1 and extract another vital parameter, su
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Investigating the Nature of Bacterial Spores' in the context of a Seventh Framework call.

assistant: **Objectives**

When triggered by nutrient limitation, the Gram-positive bacterium Bacillus subtilis and its relatives enter a pathway of cellular differentiation culminating in the formation of a dormant cell type called a spore, the most resilient cell type known. Bacterial spores can survive for long periods of time and are able to endure extremes of heat, radiation and chemical assault. Remarkably, dormant spores can rapidly convert back to actively growing cells by a process called germination. Consequently, spore forming bacteria, including dangerous pathogens, (such as C. botulinum and B. anthracis) are highly resistant to antibacterial treatments and difficult to eradicate. Despite significant advances in our understanding of the process of spore formation, little is known about the nature of the mature spore. It is unrevealed how dormancy is maintained within the spore and how it is ceased, as the organization and the dynamics of the spore macromolecules remain obscure. The unusual biochemical and biophysical characteristics of the dormant spore make it a challenging biological system to investigate using conventional methods, and thus set the need to develop innovative approaches to study spore biology. We propose to explore the nature of spores by using B. subtilis as a primary experimental system. We intend to: (1) define the architecture of the spore chromosome, (2) track the complexity and fate of mRNA and protein molecules during sporulation, dormancy and germination, (3) revisit the basic notion of the spore dormancy (is it metabolically inert?), (4) compare the characteristics of bacilli spores from diverse ecophysiological groups, (5) investigate the features of spores belonging to distant bacterial genera, (6) generate an integrative database that categorizes the mol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'An analyzer for preterm EEG' to be submitted under Horizon 2020.

assistant: **Abstract**

Compromised early brain development leads to lifelong disabilities, which have a heavy impact on the child, families, as well as society as a whole. Advances in clinical care have led to an increasing number of babies surviving extreme prematurity. The global challenge is to avoid early brain injuries by optimizing neurological care during the early days of neonatal intensive care. This aim necessitates the use of constant, cot-side brain monitoring using the electroencephalograph (EEG), which faces formidable logistic challenges due to the need for large scale data analysis by EEG experts. The only imaginable solution for dealing with the vast amount of EEG information is to automate EEG analysis. This action proposes the development of an original, automated, cot-side Analyser for Preterm EEG (APE). This algorithm will be based on the combination of state of the art biomedical signal processing techniques and recent advances in basic developmental neuroscience. An accurate cot side EEG analyser has strong clinical potential for improving early brain care, leading to lifelong improvements in affected individuals as well as unprecedented opportunities to benchmark new brain interventions. The project will significantly develop the applicant’s career by adding new domains of human neurophysiology and basic neuroscience, bio-signal analysis, as well as conduct of international research projects to his skillset. His secondment to a well-established Finnish SME in the field, MegaEMG, will provide insight into the development of medical devices, commercialization, and regularity environment. The technology developed in this project is translatable into medical devices, providing an opportunity to enhance Europe’s status as a market leader in brain monitoring devices, as well
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'dUTPase Signalling: from Phage to Eukaryotes' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

dUTPases (DUTs) are enzymes that regulate cellular dUTP levels to prevent the misincorporation of uracil into DNA. Recently however, DUTs have been involved in the control of relevant cellular processes. How these regulatory functions are controlled remains unsolved. The recent elucidation of the mechanistic role of DUTs in the transfer of staphylococcal pathogenicity islands (SaPIs) by our group has revealed an entirely novel and surprising strategy involving DUTs in signalling. Namely, we have demonstrated that in addition to the 5 classical domains present in all the trimeric DUTs, staphylococcal phage-encoded DUT proteins possess an extra region (Motif VI) involved in SaPI de-repression by binding to the SaPI-encoded repressor (Stl). Although this domain is necessary, it does not suffice to induce the SaPI cycle. Unexpectedly, the strongly conserved DUT motif V is also inherently involved in mediating de-repression. Crystallographic and mutagenic analyses have demonstrated that binding to dUTP orders the C-terminal motif V of phage-encoded DUTs, potentially rendering these proteins in the conformation required for SaPI de-repression. In contrast, conversion into the apo state conformation by the hydrolysis of the bound dUTP disorders motif V and generates a protein that is unable to induce the SaPI cycle. Analogously, previous work demonstrated that the trimeric rat DUT interacts with the transcriptional factor PPARα, an interaction that depends on an “extra” N-terminal motif VI present in the DUT protein and requires the C-terminal domain contribution, strongly supporting in general the mechanism involving DUTs in signalling. In summary, our results suggest that DUTs define a widespread family of signalling molecules that acts analogously to eukaryotic G-proteins.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MSCA 2020 - Achieving more together' (2014-2020).

assistant: **Innovation**

The second half of 2020 is a crucial time for Research and Innovation in Europe. The new framework programme ""Horizon Europe"" will start in 2021 (though the start depends on an agreement of the multi annual financial framework, nevertheless, this agreement should be reached during the German presidency), and with it a new seven year span of the MSCA. Moreover, new initiatives in the European research and education landscape have just started with the ""European Universities Initiative"" probably as their most prominent one. The MSCA German Council Presidency Conference “MSCA 2020 – Achieving more together” will address different MSCA topics embedded into greater political contexts. The focus will be on: 1. MSCA and European Universities: As for the ERA, council conclusions on the European Universities Initiative are planned for November 2020 during the German Presidency. The German MSCA conference seems to be the right place to draw the first conclusions of this initiative and to determine wishful synergies. 2. Supervision in MSCA: We would like to put the focus on the highly important, but so far neglected group of supervisors in MSCA, and shed light on their challenges. Written guidelines for good supervision shall be a result of the conference, which will be done in a working group to be initiated in 2020.""


**Keywords:** MSCA, European Research Area, Horizon Europe, Supervision, Science Communication, European Universities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Promoting SINgle cell GEnomics to explore the ecology and evolution of hidden microeuKaryotes' (SINGEK), addressing dissemination and exploitation.

assistant: **Impact**

Environmental microbial surveys have revealed a remarkable diversity of microeukaryotic life in most ecosystems, the majority of which had previously escaped detection. From an ecological point of view this work highlighted our ignorance of critical microbial players in natural environmental processes, including primary production, biogeochemical cycling and trophic interactions such as parasitism and grazing. Consequently, our understanding of community function is partial, limiting our ability to study environmental change. While, from an evolutionary perspective, we are missing major components of the Tree of Life giving rise to a fragmented understanding of how major cellular functions have evolved.  Single cell genomics (SCG), including single cell transcriptomics, is an emerging technology that has the potential to retrieve genomic information from individual uncultured microbes recovered directly from natural environments and promises to provide new tools to investigate microeukaryotes in unparalleled detail. The aim of this ITN is therefore to train a new generation of scientists with the highest expertise, in SCG, from the initial stages of cell sorting to genome sequencing and gene annotation, to the full exploitation of the data obtained. Such progress will allow the European research community for the first time to address critical ecological and evolutionary questions. SINGEK will drive training through research by both local and network-wide activities, secondments, and workshops, and by establishing an environment that extends far beyond each partner team. This training environment will also provide the transferable skills essential for successful career development. This network of well connected and highly qualified scientists with expertise in eukaryot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'a novel drug for prevention and treatment peripheral neuropathy symptoms' to be submitted under Horizon 2020.

assistant: **Abstract**

There will be over 18m new cases of cancer worldwide in 20181, out of which about 3,7m in Europe alone. Studies estimate that up to 40% of all cancer patients develop chemotherapy-induced peripheral sensory neuropathy (CIPN), meaning over 1,6m patients in EU and 7,2m world-wide may experience CIPN each year. This group is only growing in number, due to the constant growth in new cases of diagnosed cancer. The new immuno-oncology drugs are increasingly being used in combination with chemotherapy. CIPN is a condition that affects the peripheral nervous system, leading to long-lasting, painful, and difficult-to-treat symptoms in the central nervous system, lowering the patient’s life quality and impeding patient’s normal activities. In fact, the CIPN induced pain is so strong and troublesome that many patients stop their cancer chemotherapy treatment prematurely. Regardless of the big and increasing number of people suffering from CIPN, only moderately effective therapies are available for the treatment, none specifically developed for CIPN, with substantial risks and unpleasant side effects for patients. Metys Pharmaceuticals is developing MP-101 - a novel, non-sedating, painkiller for prevention and for treatment of CIPN-associated neuropathic pain. Chemotherapeutic agents damage peripheral nerve endings, causing excessive signaling and sensitization which involves the eurotransmitter glutamate: this leads to prolonged excitation of the central nerves of the spine and brain. MP-101 acts as glutamate modulator, diminishing the strength of glutamate stimulation, or, if given early enough, preventing glutamate-dependent sensitization. During the phase 1 project, a go-to-market strategy and a supply chain will be established, as well as further development plan will be draft
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Studies on the immunoregulatory functions of il 6 and il 10 during the course of visceral leishmaniasis implications for a rational immunochemotherapy' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Visceral leishmaniasis (VL) caused by the protozoan parasites L. donovani and L. infantum (L. chagasi) is a potentially fatal disease with a major impact on health in the developing countries For many years however, a dramatic increase in the number of leishmanial infections in HIV positive patients from endemic areas has been noted along with cases refractory to curren antimonial chemotherapy. As an intact immunological system is necessary for drug therapy to b effective, studies concerning the nature of the interaction between drugs and the immune responsz are of paramount importance. The main objectives of our proposal are 1r) to assess the nature of the immune response occuring during chemotherapy for VL in a murine model, concentrating on interleukines (IL) 6 and 10 witl known macrophage de-activating effects, 2r) to study the pathogenesis of VL in IL-6 deficient mice and 3r) to evaluate the consequences of immune modulation such as cytokine neutralisation (IL-6 and/or IL- 10) for effective chemotherapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Effects of global change on the emission, fate, effects and risks of chemicals in aquatic ecosystems' (ECORISK2050).

assistant: **Concept**

By 2050, the world population will reach nine billion people and three quarters of the global population will live in cities. The development path to 2050 will be marked by shifts in land-use and weather patterns, and by changes in the way water and food resources are obtained and managed all over the world. These global changes (GCs) will affect the emissions, environmental transport pathways and fate of chemicals, and thus affect the exposure of the natural environment to chemicals. Future changes may also alter the sensitivity of ecosystems to chemical exposure. Therefore, the ECORISK2050 project brings together a world leading and interdisciplinary consortium of universities, research institutes, industry and regulatory and governmental authorities to deliver a cohort of Early Stage Researchers (ESRs). The coupled training goals and research objectives of the project are: (1) to assess how the inputs of chemicals from agriculture and urban environments and their fate and transport are affected by different environmental conditions, including those of specific EU regions, and how this will change under GC scenarios in order to assess the likely increase in chemical risks to human and ecosystem health; (2) to identify potential adaptation and mitigation strategies that can be implemented in the short and medium term, to abate unacceptable changes in risks, and use the GC scenarios to propose robust implementation pathways, and (3) to develop a set of tools for use by industry and policy makers, that allow the impacts of a range of GC-related drivers on chemicals risks to be assessed and managed. The project will deliver the next generation of scientists, consultants and industry and governmental decision-makers who have the knowledge and skill sets required to address