RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Expression, enzymology and structural determination of the new phosphatase ship2' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The SH2-containig inositol 5-phosphase (SHIP2) is a new PtdInsP3 5-phophatase directly involved in insulin sensitivity . The two main objectives of this project are: a ) obtain recombinant SHIP2 in large amounts to develop a rapid assay of activity b ) determine structural infonnation after cristallography . For the first six months, we would like to produce SHIP2 or the catalytic domain of SHIP2 either in baculo-infected cells or in bacteria. Then, for the next six months, we would like to set up a large scale production of the protein. This recombinant protein will be used on the one hand to develop a rapid activity assay , and on the other hand to permit the cristallisation of SHIP2. So, the second year, we would like to obtain cristals of SHIP2, to do the diffraction of the x- rays. The structural detennination of SHIP2, and more particularly of SHIP2 catalytic site will provide tools for structure-based design of selective inhibitors of SHIP2 phosphatase. And these inhibitors will have potential application for the treatment of type II diabete.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Structural characterization of a mammalian mitochondrial ribosome and its complexes by the X-ray crystallography' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The ribosome is a large ribonucleoprotein particle which translates mRNA to proteins through a sophisticated process that combines high speed and accuracy. It thus plays a central role in protein biosynthesis, translation, which is a fundamental and essential process in all cells. Mitochondria contain a translational system that is distinct from that of the cell cytoplasm. Mitochondrial ribosomes have remarkable divergence from those of bacteria and the eukaryotic cytoplasm. Most of the mitochondrial ribosomal proteins are unique, having no closely related homologues in bacterial or eukaryotic-cytoplasmic ribosomes. Furthermore, mitoribosomes have acquired an intrinsic GTP binding protein. In the proposed project we aim to address several central questions pertaining to the mechanism of mitochondrial ribosome by exploring its three dimensional structure. We take the challenge for the first time to crystallize and determine the X-ray structure of the mitochondrial ribosome from bovine heart mitochondria. A high-resolution structure of the mitoribosome is likely to be a challenging goal. However, we believe the collaboration proposed here that combines the strengths of two groups, V. Ramakrishnan and J. Walker, supplemented by the previous experience of the applicant in determining the structure of large macromolecular complexes containing high non-protein content, provides a unique opportunity to mount an attack on this problem. Studying the mitochondrial ribosome will have an important medical impact due to the fact that many of the adverse side effects of therapeutically important antibacterial antibiotics are ascribed to inhibitory effects on mitochondrial ribosomes, as well as many genetic diseases. The structure determination of mitoribosome is expected to require n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Hybrid ElectriC regional Aircraft distribution TEchnologies', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Aviation needs to meet the ambitious targets of the European Green Deal. This means a step change is needed towards hybrid electric regional aircraft to significantly reduce the fuel burn. This can only be accomplished with power distribution networks that can safely handle the high power and high voltage levels, ultimately up to several Megawatt. The HECATE project will address the associated challenges of system weight and power density, high voltage challenges with lightning, arcing and electromagnetic interference as well as optimized thermal management, in addition to digitizing the design process with digital twins. This will lead to transformative technology bricks, which are holistically optimized at system integration architecture level. The HECATE project will demonstrate a >500 kW architecture in a copper bird at TRL5. This will provide a clearer understanding of high voltage challenges and how to mitigate them, with a scalability roadmap towards CAJU Phase 2 flight demonstration and exploitation in a 2035 new built Hybrid Electric Regional aircraft. Also, environmental impact and LCA will be assessed. For optimal alignment and ensuring certifiability, HECATE will establish relationships with other Clean Aviation projects (e.g. HER-01 for MW propulsion, HER-02 for thermal, TRA-01 for architecture, TRA-02 for certification) and authorities and standards groups (e.g. EASA, EUROCAE).  As a set of key enabling technologies that are well integrated, HECATE will contribute to the Clean Aviation SRIA and its expected impacts, and fully fulfill the call's expected outcomes. The 37-member consortium mobilizes key EU based industries throughout the entire existing supply chain: from aircraft OEMs to system integrators, to system and subsystems suppliers, 5 of which are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Aquaporin blockers for novel skin care products and diuretics' under Fifth Framework.

assistant: **Concept**

Disturbances of body water balance severely affect the quality of life and can lead to life-threatening conditions. Aqua Orin (AQP) water channels play central roles in human water balance and are novel targets for pharmacological intervention. To screen for blockers (aqua plugs) of Asps, mammalian and yeast cell systems will be established. Inhibitors of aqua Orin function will be identified in compound libraries and rationally designed. The activity, specificity and toxicity profile of these aqua plugs will be determined in optimised cell- and integrated, systems. The atomic structures of Asps and AQP-aqua plug complexes will be elucidated and used to design optimised aqua Orin inhibitors. Studies will be performed to further determine the role of Asps in organ water balance in health and disease to identify additional conditions where Asps are targets for pharmaceutical application of aqua plugs. Identified aqua plugs with promising profiles will serve as lead structures for the development and exploitation of specific aqua Orin inhibitors in novel skin care products and diuretics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Folate-based nanobiodevices for integrated diagnosis/therapy targeting chronic inflammatory diseases' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

NANOFOL proposes to develop a new diagnostic/therapy approach using folate based nanobiodevices (FBN) able to provide a new type of cost efficient treatment for chronic inflammatory diseases such as Atherosclerosis and Rheumatoid Arthritis with low side effects that will constitute a more advantageous solution than current therapies.  NANOFOL will achieve all that by fulfilling the following objectives: •Design , development and production of nanobiodevices (FBN) targeting directly effector cells •Proof of concept in vitro and in vivo of a folate based nanodevice targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept in vitro and in vivo of a nanodevice containing a bispecific antibody (against folate receptor and another macrophage marker) targeting activated macrophages  in chronic inflammation not affecting bystander cells •Proof of concept of FBN delivery therapeutic agents (by small interfering ribonucleic acid molecules (siRNA) or lipophylic molecules) targeting inflammatory signaling pathways •In vitro and in vivo testing of cellular toxicity caused by the novel nanobiodevices in cells other than activated macrophages •Design of models that will enable to minimize animal experimentation. •Development of a strategy to assess potential risks in order to ensure nanobiodevice safe delivery. NANOFOL has adopted a specific risk strategy to attain objectives in a step by step approach allowing improving gradually the concept (specificity, stability, side effects efficacy) from the lower to the higher risky solutions ensuring reduced experimental animal testing and high human safety. The NANOFOL project will combine expertise in nanotechnologies, biology, chemistry, materials science, biotechnology, engineering, risk analy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Interfacing interacting Rydberg polaritons: From few- to many-body interactions'.

assistant: **Concept**

Rydberg quantum optics (RQO) is a very promising approach to achieve effective interactions at the level of individual photons. It maps the strong interactions between ultracold Rydberg atoms onto light fields to create strongly interacting Rydberg polaritons. RQO enables single photon generation, exotic photon bound states, and effective interactions between spatially separated photons. Based on RQO, various quantum optical devices can be implemented, e.g. a deterministic gate for optical quantum information processing. Experiments to date have mostly used 1D interaction geometries and not yet investigated interactions between more than 2 or 3 polaritons or in a quantum network of interaction nodes. InterPol will implement controlled interactions between multiple Rydberg polaritons based on two complementary approaches. One will cascade multiple devices such as single-photon transistors and subtractors to implement multi-polariton logic circuits and demonstrate a network that coherently interfaces entangled Rydberg excitations with photons for quantum state transfer. The second will use adaptive optics to realize a novel, highly flexible platform to study simultaneous interactions between multiple polaritons in arbitrary spatial geometries to study the transition regime from few- to many-body interactions. This has fundamental impact beyond quantum optics as it will allow highly controlled experimental tests of many-body interactions and non-perturbative effects in quantum field theories with quasi-particles in a tabletop setting. Collaborating with leading theorists to experimentally benchmark field-theoretical descriptions, the applicant will further deepen his theoretical understanding of RQO to complement his excellent experimental skills. In charge of a comprehens
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A High-volume Fusion and Analysis Platform \nfor Geospatial Point Clouds, Coverages and Volumetric Data Sets' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

For geospatial applications, huge amounts of heterogeneous data sets of different topology are collected nowadays with different data acquisition techniques. Especially airborne and mobile platform LIDAR data are becoming ubiquitous, but SAR and stereophotogrammetry also contribute to the rapid growth of geotopographical data sets to sizes of tens to hundreds of TBs. Due to the problems of handling such large data volumes and the difficulty of fusing point clouds of heterogeneous provenance, rasters, volumetric data and 2D vector data, many of those new data sets are not used appropriately or not at all.Therefore, IQmulus is targeting to enable optimized use of large, heterogeneous geo-spatial data sets for better decision making through a high-volume fusion and analysis information management platform. This platform will transpose approaches and IT standards from distributed computing to enable distributed, service-oriented geospatial processing. We will determine optimal execution and distribution parameters for different geospatial processing tasks and to ensure that the IQmulus system can transparently execute processing on different architectures like GPGPU clusters or clouds. Methods will be developed to connect processing and visualization into a tight loop, ensuring high interactivity in the process to enable users to better understand correlations between heterogeneous data sets.Two testbeds will be implemented in IQmulus (Maritime Spatial Planning & Land Applications for Rapid Response and Territorial Management) to show the benefits of the approach for decision makers such as European industries interested in exploiting sea-borne resources such as renewable energy from wind parks, and citizens  affected by emergency cases that require quick response. Result d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A tissue-on-a-chip platform for systems-level studies of ALS pathology and drug screening' (Als-on-a-chip), addressing dissemination and exploitation.

assistant: **Impact**

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease, which affects approximately 2 per 100000 people. Currently, there is no ALS treatment. The main tool for preclinical ALS studies is the hSOD1G93A mouse. However, despite promising results in this model, all candidate drugs failed in clinical trials. These failures have been partly attributed to differences in the physiology of human and mice nerve cells, and the inability of the established drug design approach to block ALS pathology. There is urgent need for new tools that will complement this mouse model, improve understanding of ALS pathology, and suggest better leads for clinical trials.The objective of the proposed study is to develop a tissue-on-a-chip platform for systems-level studies of ALS pathology and drug screening. The system is built around a novel thin porous scaffold, where systems of normal or ALS-type mouse and human motor neurons will be cultured inside an appropriate 3D ECM analog, and their response (intracellular signaling, cell processes, cell-cell communication) to stimuli panels in the presence of drugs will be quantified via high-throughput proteomics and fluorescent imaging. Acquired data will be interpreted by modifications of state-of-the-art system biology tools.The outcomes of the proposed research can lead to new ALS treatments by identifying new drug targets (via mechanistic description of ALS pathology), and by developing better ways to evaluate candidate drugs before clinical trials (via comparing drug response in human and mouse cells). Results can be translated to other neurodegenerative diseases. Finally, the proposal offers an opportunity to a promising researcher to relocate from MIT to Greece, collaborate with a leading neurobiology lab in a world-class en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enzymatic modification of wool (BIOWOOL)' in the context of a Fifth Framework call.

assistant: **Objectives**

The objective of this project is to develop enzyme-based finishing processes for wool with special emphasis on shrink-resist treatments, which provide the flexibility and low pollution characteristics demanded by the global textile market. This project will develop novel non-proteolytic enzyme systems to be used for surface specific modification of wool fibres. The novel enzyme activities will be screened from a variety of micro-organisms, the efficiency of the enzyme activities on wool fibres will be monitored with advanced surface analytical methods as well as technical performance measurements. The most practical enzyme processes will be developed in laboratory scale machinery and the technical effects with respect to shrink-resistance, handle, softness and dye ability will be evaluated. Potential enzymes will be produced in large scale using modern molecular genetics and subsequently the wool processes will be assessed in pilot and industrial scale. The project outcome will be novel enzyme systems for wool modification eco-efficient processes for wool finishing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Aerial Robotics Cooperative Assembly System', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The ARCAS project proposes the development and experimental validation of the first cooperative free-flying robot system for assembly and structure construction. The project will pave the way for a large number of applications including the building of platforms for evacuation of people or landing aircrafts, the inspection and maintenance of facilities and the construction of structures in inaccessible sites and in the space.The detailed scientific and technological objectives are:1)New methods for motion control of a free-flying robot with mounted manipulator in contact with a grasped object as well as for coordinated control of multiple cooperating flying robots with manipulators in contact with the same object (e.g. for precise placement or joint manipulation)2)New flying robot perception methods to model, identify and recognize the scenario and to be used for the guidance in the assembly operation, including fast generation of 3D models, aerial 3D SLAM, 3D tracking and cooperative perception3)New methods for the cooperative assembly planning and structure construction by means of multiple flying robots with application to inspection and maintenance activities4)Strategies for operator assistance, including visual and force feedback, in manipulation tasks involving multiple cooperating flying robotsThe above methods and technologies will be integrated in the ARCAS cooperative flying robot system that  will be validated in the following scenarios: a) Indoor testbed with quadrotors, b) Outdoor scenario with helicopters, c) free-flying simulation using multiple robot arms.The project will be implemented by a high-quality consortium whose partners have already demonstrated the cooperative transportation by aerial robots as well as high performance cooperative ground manip
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Annual Polish conferences are setting up a new platform for dissemination of knowledge in the field of catalysis'.

assistant: **Concept**

The objective of the proposal is to organise a set of three conferences in Cracow (Poland), focused on catalysis and catalytic technologies. Institute of Catalysis and Surface Chemistry (ICSC) is the only entity in Poland and one of a few in the world focu sed entirely on multidisciplinary catalytic research. The rôle of the institute will be: - to establish an efficient tool for dissemination of knowledge within the country; - to form and maintain creative links with the leading scientists and institutions in Europe; - to exchange information and identify by discussion new problems in catalysis, focused both on fundamental research and industry-driven applied research. Institute will strengthen existing and form new links between universities and industrial enterprises in Poland. The proposal will help to establish and strengthen links between the ICSC and similar entities in Europe, thus integrating it into the European Research Area.