RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Wastewater pollution load monitor' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Objectives and content:Industrial companies producing wastewater are under increasing pressure to reduce the polluting load of their waste and to monitor the wastewater they discharge to sewer or direct to the environment. This activity is predominantly carried out using sampling and laboratory analysis, which is labour intensive, may miss damaging peak loads and is too slow to allow any preventive action to be taken. The industrial objective of the LOADMON project is, on exploitation, to provide pollution load monitoring equipment, which is economical and reliable to meet this industrial need and reduce operating costs. The equipment will also assist wastewater treatment plant operators, by providing reliable affordable equipment to monitor and control the process, particularly the treatment load within the upstream wastewater networks. Another objective is to provide reliable equipment for environmental monitoring, especially for intermittent and variable discharges, which are presently poorly served. LOADMON will also support the move towards pollution control over large regions, where obtaining good quality data is currently very expensive. The wastewater measurement environment is very hostile for instrumentation, and the concentration of pollutants at present can only be monitored continuously by using expensive sample preparation and automatic chemical analysis equipment, which both require frequent maintenance. The LOADMON project will develop equipment using non-contact techniques to measure suspended solids, organic load as Biochemical Oxygen Demand (BOD) and Chemical Oxygen Demand (COD), nitrate, phosphate, ammonia and flow. The final hardware deliverable will be an optical prototype system with sophisticated data processing, capable of safe use in a hazardou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Industry and Doctoral Training in Vote Advice Applications' under Seventh Framework.

assistant: **Concept**

Doctoral and Industry Training in Voting Advice ApplicationsIn a review of current survey research, Roger Tourangeau (2004) wrote that “Surveys reflect societal change in a way that few other research tools do” (p775). Surveys and the analyses of survey responses are the bread and butter of research into the most challenging social problems. However, the random probability sample survey is sensitive to changes in both technology and lifestyle. From increases in personal wealth, higher mobility, language diversity brought about by immigration and technological changes such as the introduction and widespread adoption of mobile phones has led to challenging methodological issues for survey research. The Doctoral and Industry Training network merges technological advances in online tools with state of the art research on political behaviour to develop new methodologies and techniques for collecting and analysing social data to address this challenge in social research.  In VOTEADVICE, we bring together an industry at the forefront of online vote advice applications and doctoral training by a leading UK university to deliver doctoral and complementary training to 3 early stage researchers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Comprehensive Analysis of RBM20-induced Dilated Cardiomyopathies using Omics Approaches and Repair Interventions' under Horizon Europe.

assistant: **Concept**

In CARDIOREPAIR, we aim to identify and repair disease-causing variants in dilated cardiomyopathy (DCM), the major contributor to heart failure. We focus on the gene RBM20 mutated in patients with a highly penetrant and aggressive form of familial DCM. We will create a comprehensive map of all possible RBM20 variants that can cause DCM and develop a therapeutic approach for mutations with the strongest effect size. Enabled by a multitude of new technologies developed in our groups, the primary goal is to characterize the complete spectrum of amino acid mutations in RBM20 by high-throughput saturation mutagenesis screens. Combined with functional readouts and multi-omics analysis of downstream processes, we will classify and score the pathogenicity of each individual mutant (objective 1). To this end, we will cover both the known DCM-causing RBM20 variants, as well as those that have not been identified in patients yet. Each mutant, represented by a typical transcriptomic, proteomic, phosphoproteomic, and microscopic fingerprint, will guide us in finding novel class-specific therapeutic strategies to revert the deviant phenotype back to the healthy state. For a subset of mutants representing each identified mutation class, we will generate mouse models and investigate changes in heart physiology and ultrastructure linked to the altered ‘ome’ profile. Our second goal is to establish a class-specific therapeutic approach for the treatment of patients harboring RBM20 mutations (objective 2). We will implement our advances in muscle-specific gene editing, focusing on prime editing and nanobody-guided approaches to specifically tackle the mutations leading to RBM20 translocation. This proposal serves as a blueprint for going from variant identification to therapy in an accele
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Secure Location-Aware Cooperative Network-Coded WSNs for better Quality of  Life' to be submitted under Seventh Framework.

assistant: **Abstract**

WSN4QoL aims at bringing together experts, from industry and academia, with the long-term goal of designing and developing a more efficient pervasive healthcare system in the interest of the society. WSN4QoL wishes to achieve this objective by enhancing and promoting the industry-academia cooperation, as well as by creating a long-term cooperation program among industrial and academic partners in the area of advanced Wireless Sensor Network (WSN) technologies for pervasive healthcare applications. WSN4QoL aims at providing new cooperative protocols, Network Coding (NC) for multi-hop/cooperative diversity, and distributed localization algorithms are developed to meet the specific requirements of WSNs-enabled healthcare applications, and to overcome the limitations of existing services and products. The proposed solutions are developed by taking into account the specific requirements of pervasive healthcare e.g. energy-efficiency, low-latency, data reliability, context-awareness, and security. Furthermore, WSN4QoL aims at providing a proof-of-concept of the proposed solutions through the realization of experiments with real healthcare devices. WSN4QoL achieves these objectives via the fruitful collaboration of three partners, one from academia, i.e., UPC, one SME, i.e., VIDAVO, and a Spin-Off of the University of L’Aquila(Italy), i.e., WEST. As a whole, the partners have consolidated and complementary expertise in the analysis, design, and experimentation of WSNs and their application to pervasive healthcare. Finally, we mention that this is the re-submission of a project submitted in 2009. This new proposal has been significantly re-shaped and updated by taking into account the suggestions of the evaluators. We have significantly improved its organization, with main emph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cell signaling pathways and epigenetic mechanisms controlling the differentiation of medullary thymic epithelial cells, key mediators in the induction of central self-tolerance' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Immunological tolerance is essential in preventing autoimmunity. The establishment of T-cell tolerance is induced in the thymus mainly by the deletion of hazardous autoreactive T cells. Medullary thymic epithelial cells (mTECs) are critical in this process because they express a diverse repertoire of peripheral tissue-restricted self-antigens (TRAs). Hazardous developing T-cells recognizing these TRAs with a high affinity are deleted. TRA expression is regulated by a transcription factor: the autoimmune regulator, Aire. I have demonstrated that antigen (Ag)-specific interactions with autoreactive CD4+ thymocytes play a privileged role in governing the differentiation of Aire+ mTECs. Although these cell interactions are of pivotal importance for T-cell tolerance induction, the underlying molecular mechanisms remain to be characterized. This proposal will define the affinity threshold required for driving CD4+ thymocytes mediated Aire+ mTEC differentiation. We will particularly determine whether mTEC differentiation is coupled to deletion of autoreactive CD4+ thymocytes or whether it corresponds to a dissociable event. We will investigate the epigenetic regulation and the gene expression program that drive the differentiation of Aire+ mTECs induced by CD4+ thymocyte interactions. For this, we will take advantage of genetically modified mice in which Ag presentation to CD4+ T cells is selectively abrogated in mTECs. A particular emphasis will be given to the molecular and epigenetic regulation of the Aire gene locus. This work will entail the use of cutting edge techniques in molecular biology (e.g. ChIP-seq or RNA-seq) and in cellular biology (e.g. fetal thymic organoculture) and will involve the use of unique transgenic mouse models. Overall, the combination of these too
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Phylogenetic taxonomy and classification of fungi' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The kingdom Fungi comprises >150,000 currently recognised species distributed across 80 classes in 20 phyla. Total species numbers are estimated at 2-3 million and our preliminary eDNA analyses suggest at least double numbers of higher-ranking taxa. However, current nomenclatural regulations fall short in DNA-based taxonomic descriptions. PhylFun aims to develop the concept and methodology for DNA-based phylogenetic classification of organisms, using fungi as examples, for an improved taxon communication and classification framework. My team will use cutting-edge methods of single-cell analysis, genomics and taxonomy for analysing our global collection of samples for DNA/sequence-based classification and providing a detailed higher-level fungal classification. We will generate large amounts of high-quality long-read DNA sequence data and create a bioinformatics platform for data management (WP1) that will be combined with the developed DNA-based classification framework (WP2) to produce an updated phylogenetic classification for fungi and potentially other microeukaryotes (WP3). PhylFun is expected to greatly benefit researchers and the public by communicating the taxa of fungi and other eukaryotic microorganisms, allowing us to consider them in conservation assessments and quarantine. The project is of a high-risk high-gain (HRHG) nature because of multiple novel methodological aspects and addressing one of the greatest gaps in taxonomy and classification related to rapid technological advances, whereas the proposed amendments for using DNA/sequence characters as types or in descriptions/diagnoses may be voted down by morphotaxonomists. Nonetheless, the potential benefits for the entire taxonomic and research community can be enormous by finally anchoring the “dark mat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'CLimate science for Evaluation of changing Socioeconomic ImpactS', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Climate change (CC) poses numerous risks to society. Amongst these, recent work has quantified the impacts which adverse climate conditions can exert on economic growth and inflation by applying empirical models (EMs) to historical data. Evaluation of the extent to which historical and future CC is changing such impacts is crucial for translating these empirical insights into actionable knowledge. Two key examples are quantifying the historical anthropogenic contribution to intensified impacts, and accurately projecting their near-term changes. These tasks face challenges because climate model ensembles often under-estimate forced changes in impact-relevant conditions such as extremes, and near-term changes are affected by both greenhouse forcing and internal variability, with the latter amplifying or masking impacts over decadal timescales. KLESIS proposes to extend recent methodological developments in climate science to overcome these obstacles to an accurate evaluation of how climate impacts are changing. First, we will develop and apply statistical methods to attribute historical changes in impact-relevant climate conditions directly from observations. These methods will be tested in climate models, applied to observations and combined with EMs to evaluate the anthropogenic contribution to historical changes in climate impacts on the economy, crucial for informing loss and damage debates. Second, we will extend state-of-the-art decadal climate prediction systems to include impact-relevant conditions. Combining these with EMs will provide near-term estimates of climate impacts which accurately reflect the important and otherwise neglected role of internal climate variability. Finally, near-term projections of impacts on economic growth and inflation will be dissemin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Large Scale Monitoring of Broadband Internet Infrastructure' (LOBSTER) under Sixth Framework.

assistant: **Objectives**

Network monitoring and measurement is increasingly regarded as an essential function for developing and supporting high-quality networkservices, building and improving innovative networking technologies, analyzing infrastructure trends and user behavior, and improving the security of our cyber-infrastructure. Accurate network monitoring systems give rise to a wide variety of new applications including provision of early warning for the detection of Internet  worms as soon as they start to spread,detection of Distributed-Denial-of-Service attacks even before they are launched, accurate traffic characterization even for applications that use dynamically generated ports such as peer-to-peer systems, and accurate traffic weather service for GRID-enabled applications. Although accurate network monitoring  is getting increasingly important for the reliable and efficient operation of our cyber-infrastructure, current traffic monitoring systems in Europe do not provide the information needed to support the above-mentioned applications.  Indeed, current systems focus either on collecting lossy flow-level statistics, or in actively measuring latency, bandwidth, error rate and similar properties of network links. In LOBSTER we propose to design and deploy a advanced European Infrastructure for accurate Internet traffic monitoring. Although such an infrastructure poses challenging research questions, we believe that we have successfully met these challenges within the currently running SCAMPI IST FP5 project, that designed and developed a passive network traffic monitoring system for speeds up to 10Gbps. Based on passive monitoring, and capitalizing on ourexperience gained in the SCAMPI IST project, the LOBSTER infrastructure will be unique in Europe and among the only two similar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Contribution of the Third Sector to Europe’s Socio-economic Development' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The main objective of the proposed research project is to create knowledge that will further advance the contributions that the third sector and volunteering can make to the socio-economic development of Europe. These unique ‘renewable resources’ for social and economic problem-solving and civic engagement in Europe are needed more than ever at this time of social and economic distress and enormous pressures on governmental budgets—not as an alternative to government but as a full-fledged partner in the effort to promote European progress. To take full advantage of this resource we need a clearer understanding of the third sector’s scope and scale, its existing and potential impacts, and the barriers to its full contributions to the continent’s common welfare. Building on our previous work, this project seeks to:1) Clarify the concept of the third sector in its European manifestations;2) Identify the major contours of the sector so defined—its size, structure, composition, sources of support, and recent trends;3) Identify the impacts of this sector, its contributions to European economic development, innovation, citizen well-being, civic engagement, and human development, and to create capabilities to measure these contributions into the future;4) Identify barriers both internal to organizations and external to them and suggest ways these barriers might be overcome; and5) Forge a partnership between the research community and European Third Sector practitioners so that the understanding of the Third Sector generated by this work remains grounded in reality and enjoy sufficient support among key stakeholders to ensure respectful attention from policy makers and sector leaders long after the project is completed.By drawing on the combined strengths of the academic communi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'European study of carbon in the ocean, biosphere and the atmosphere.'.

assistant: **Innovation**

The long-term goal of ESCOBA is to investigate, quantify, model and eventually predict the behavior of the global carbon cycle in response to the perturbation by man and with respect to its interaction with the physical climate system on timescales of up to several hundred years. The objectives of ESCOBA-Biosphere are to forecast interactions (impacts and feedbacks) between terrestrial biosphere, soils, and climate on global scale. Existing vegetation and soil models developed during the first phase of the project will be validated and run for several years. The improved description and modeling of the main processes that govern the role of vegetation and soils in the carbon cycle will be the main task of the project.The ESCOBA-Biosphere project will investigate vegetation and soil processes on time-scales from days to a few years. Terrestrial Biogeochemical Models (TBM) have been built that account for processes such as photosynthesis, autotrophic and heterotrophic respiration, carbon allocation, canopy development, and litter formation. Models will be run with short time steps, typically from hours to day, and further integrated to predict daily to monthly average of carbon and water exchanges, and monthly to annual Net Primary Productivity (NPP) and Net Ecosystem Productivity (NEP). As far as possible, basic vegetation and soil processes will be described in a mechanistic way in order to increase the reliability of the models when they will be run under different environmental conditions such as increased atmospheric CO2 concentration, changing temperature and precipitation. The main tools for testing this reliability will be the spatial and interannual variability of climate during the past 10 years and its impact on the carbon cycle as monitored by satellite data,