RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Limits of Demobilization, 1917-1923: Paramilitary Violence in Europe and the Wider World' under Seventh Framework.

assistant: **Concept**

The purpose of the proposed project is to think afresh about the violent aftermath of the Great War and its legacies. This will be achieved by forging a team of researchers who focus on the violent conflicts that erupted in many of the former combatant states after 1917/18 from a comparative or transnational global perspective and the ways in which these conflicts were avoided in other areas. The project will differ from previous attempts to analyse the violent transition from war to peace in this period in several ways: The first is its comparative and transational complexion. Despite recent attempts to write transnational histories of the Great War, the global history of its immediate aftermath is yet to be written. War and the politics of conflicts (and its aftermaths) are still largely studied according to divisions of national identity or ethnic difference. And yet clearly the First World War was a phenomenon that crossed frontiers and left legacies that posessed common themes. Indeed one of its consequences, especially in East-Central Europe but also in the shatter-zones of the Ottoman Empire and colonial contexts, was the destruction of frontiers, creating spaces without order or unquestioned government authority. The project will thus approach its subject matter by zones of victory, of defeat, and of mutilated or ambivalent victories rather than nation-states as a novel way of overcoming nation-centric frameworks of analysis. In terms of chronological scope, the investigation moves away from the traditional emphasis on the years 1914-18 as the crucible years of twentieth-century history. Furthermore, the project is at once European and global, investigating the emergence of violent conflicts in both the shatter-zones of European land empires and colonial conflic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'TowArd sustainable foresigHt capabilitiEs for increAseD Civil Security'.

assistant: **Innovation**

With the rise of potentially disruptive technologies such as artificial intelligence and virtual reality, a particular challenge has emerged for LEAs and other civil security practitioners. Tasked with fostering  safe societies and protecting European citizens from new forms of criminality, they need to pre-empt technological evolutions, turning potential threats into opportunities, and anticipate the operational future of policing.Technology foresight is one possible anticipatory process. However, pure technology watch-based approaches are not helpful for decision-making if not embedded in a qualitative assessment of threats and capabilities. Hence the need to move towards a comprehensive foresight framework which is the rationale behind AHEAD.Standing for TowArd TecHnological ForEsight for IncreAseD Security, AHEAD is a LEA-led project which will adopt a 360-degree approach accounting for megatrends but also contextual elements (i.e. legal, ethical, societal and economic) to design and operationalise a sustainable capability-based civil security foresight framework. Tested through iterative Foresight Exercises addressing the five Destinations of the Horizon Europe Cluster 3 (Fighting crime and terrorism, Border management, Resilient infrastructure, Increased cybersecurity and Disaster-resilient society), this framework will be tailored to the needs of civil security practitioners to generate “evidence-based” capability roadmaps.Such roadmaps will translate the foresight process’ outcomes into concrete courses of actions to support decision- and policy-makers at EU and national levels when deciding on strategies and policy actions in the field of civil security, including the programming of security research and innovation investments. By enhancing a forward-looking cu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New microbial carbonate precipitation technology for the production of high strength, economical and Ecological Cement' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

About 5% of global carbon emissions originate from the manufacturing of cement.According to IEA,cement production generates an average world carbon emission of 0.81 kg CO2 per kg cement produced.Cement related emissions are expected to increase by 260% throughout the 1990‑2050period.As consequence,the global production of cement in 2030 is projected to grow to a level roughly 5 times higher than its level in 1990,with close to 5 billion tones worldwide.Emissions of the global cement sector alone are very likely to surpass the total amount of CO2 emissions of the EU before 2030.As well, Industrial waste is now global concern,causing environmental and economic harm.Industries are rapidly trying to find a solution,searching for optimal ways to manage waste and to change the most common practices as landfill or incineration.Industrial waste is very heavy burden for the environment,where a significant proportion of this industrial waste is attributable to construction and demolition waste.To mitigate these threats ECO-CEMENT will allow recovering valuable resources from industry,capturing CO2 and transforming both products into ecological cement that can be used in construction or novel environmental applications.Based on the nature’s way of creating natural formations through bacterial contribution to carbonate precipitation,the main objective of ECO-CEMENT is to develop a novel bio-mimetic technology for enzyme-based microbial carbonate precipitation through the revalorization of industrial waste as raw materials,in order to produce eco-efficient environmental cement.The Bio-mimetic Technology will convert industrial waste,mainly cement waste and others by-products,into high strength,ecological cement using microbial carbonate precipitation via urea hydrolysis.Internal stu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Institutional and economic instruments for sustainable water management in the Mediterranean region' (INECO) targeting Sixth Framework.

assistant: **Abstract**

The objective of INECO is to establish a Mediterranean network of research institutes, public authorities and stakeholders for coordinating research and analysing decision making practices on the application of institutional changes in the water sector. IN ECO encompasses a series of coordination activities aiming to: a) Promote the exchange of good practices, information and research between participating institutes regarding the role of institutional and economic instruments in sustainable and efficient w ater use; b) Enhance synergies between the partners of the consortium and other stakeholders through the performance of studies and the organisation of participatory workshops for assessing the efficiency of currently applied water management practices and validating alternative governance structures, economic tools and policies, and c) Formulate guidelines for alternative institutional arrangements, able to promote IWRM through the application of appropriate and socially acceptable economic instrument s. The adaptive guidelines will be integrated in a web toolbox, able to support the network beyond the lifetime of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Role of nuclear architecture in cancer development' (ACTINNUCLSHAPECANCER) under Seventh Framework.

assistant: **Objectives**

Nuclear shape is one of the gold standards for detection and characterization of cancers. Nonetheless the control of nuclear morphology and its relationship to malignant behaviors are still poorly understood. We propose to study the mechanisms that lead to nuclear dysmorphia and their consequence on nuclear functions such as genome integrity and migration. The first part of the research will start from a list of actin regulators that, in preliminary experiments, showed role in controlling nuclear shape and/or DNA repair. An integrated combination of cutting edge biophysical and imaging techniques will be exploited to analyze in detail the biophysical features of nuclei and to address the potential role of the different pools of actin on nuclear shape and deformability. A relevant part of the project will be dedicated to characterize the molecular mechanisms downstream of the candidate genes and to test their role in the context of 3D migration and genome integrity.Nuclear size and stiffness represent a significant obstacle to cell migration. However, cancer cells successfully shape their nuclei to efficiently migrate through gaps with otherwise limiting dimensions. In final part of our proposal we plan to perform a RNA interference screening to isolate genes that allows migration through limiting-size pores. The candidate hits will then be studied for their role in nuclear architecture and functions.Our proposal supports the idea that the nuclear structure might be a bridge between different hallmarks of cancer and might uncover a new layer of the control of these aggressive traits in cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'E2F3 - a potential clinical marker for prostate cancer' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Prostate cancer is now the leading cause of cancer related deaths in most European countries. However, knowledge of the underlying mechanisms is still scarce. The overall aim of this project is to identify new oncogenes involved in prostate cancer and assess their potential as clinical markers. The focus will be the E2F3 transcription factor that has an established role in cell cycle progression and has recently been proposed as a candidate oncogene for bladder cancer. Initial studies indicate that 70% of prostate cancers over-express E2F3.We will combine tissue microarray (TMA) staining data from 1200 prostate cancer patients with clinical data, and statistically analyse the correlation. We will also test the hypothesis that down regulation of pBR is needed for upregulation of E2F3 to have an impact, by studies of the pBR levels in parallel with the E2F3 analysis on the TMAs. We will determine whether the upregulation is associated with increased copy number of the gene by flourescence in situ hybridisation ( FISH) onto TMAs and, finally, the biological role of E2F3 in the development of prostate cancer will be investigated by siRNA technology in prostate cancer cell lines that over-express E2F3.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dihydrofolate reductase-thymidylate synthase from plasmodium vivax and p. falciparum as targets for antimalarial chemotherapy.' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Both dihydrofolate reductase-thymidylate synthase (DHR-TS) and DHFR from P. vivax will be cloned and expressed from E.coli. The kinetic properties of the expressed enzyme and the profiles of inhibition by various antifolates will be studied, in order to find out whether it is inherently resistant to inhibition. Mutants of P.vivax DHFR, both found in the field and artificially designed, as well as mutants of P.falciparum, will be made and studied. The results will be used to model the three-dimensional structure of the enzymes, especially around the active site. Both DHFR and DHFR-TS from the two sources will be prepared in sufficient amounts for crystallization and structure determination by X-ray diffraction. Newly designed antifolates and those synthesized previously will be tested for their inhibitory activities. The mode of binding of such agents to the enzyme will be studied both from modelling and X-ray studies. Such agents will be important as leads to new antifolate drugs against both types of malaria. Agents with activity against both P. vivax and P.falciparum DHFR will be of special interest, in view of the common occurrence of mixed infections.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Eco-evolutionary dynamics in plant-soil interactions during land use transition: consequences for soil functioning and resilience to drought' (PlantSoilAdapt).

assistant: **Concept**

European grasslands have been shaped by millennia of low-intensity management and are unique cultural and biodiversity hotspots providing critical ecosystem services. However, the area of traditionally-managed grassland has declined dramatically during the last century, with land-use intensification on productive soil and abandonment of unfertile land both causing species loss and deterioration of ecosystem services. Recent evidence suggests that land-use change also leads to genetic and phenotypic changes in plant populations. How population-level processes mediate the impact of land use on ecosystem functions and affect adaptive potential to future perturbations is entirely unknown. Filling this knowledge gap is urgent as grasslands face additional pressure from climate change, particularly an increasing frequency of droughts. I hypothesise that land use intensification and abandonment lead to evolutionary shifts in plant function away from resource conservation towards fast resource acquisition and low stress tolerance. Combined with the disruption of co-evolved mutualistic plant-microbial interactions, this has cascading effects on essential ecosystem services provided by soils and their resilience to drought-induced perturbation. The hypothesis will be tested using laboratory tests of the mechanisms underlying eco-evolutionary dynamics in plant-soil interactions during land-use change and community-level experiments to uncover the consequences of adaptation for soil functioning and resilience to drought. I will use the world's longest-running fertilization experiment and grassland networks in three European regions, representing different histories and contrasting management regimes. The project will provide a step-change in our understanding of the selective press
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular determination of Rif1-Associated Genomic Elements and their function in regulating genome activity and integrity' (RAGES).

assistant: **Concept**

DNA double-strand breaks (DSBs) are highly toxic and must usually be accurately repaired to prevent oncogenic mutations. However, DSBs also represent necessary intermediates of recombination events required to create genetic diversity in immune repertoires and the germline. These distinct cellular contexts require that DSBs are differentially metabolised to achieve the required genetic outcome. Thus a complex system has evolved to regulate DSB repair. Rif1 was recently identified as a critical regulator of DSB repair, recruited to chromatin at DSBs by the 53BP1 chromatin reader. However, little is known about how these proteins cooperate to alter the chromatin landscape at DNA damage sites, and how this influences DNA repair decisions. Understanding the molecular basis of these proteins function is paramount, as misregulation at the level of Rif1/53BP1 is known to drive disease: loss of either protein results in primary immunodeficiency, while an inability to counteract Rif1/53BP1-dependent activities during DNA repair is associated with genomic instability that drives carcinogenesis. Interestingly, recent evidence suggests that Rif1 may also mediate gene-repression in certain chromatin contexts. This raises the possibility that the manner by which Rif1 regulates transcriptional control may be similar to its role in DNA repair. In this proposal, I seek to test my hypothesis that Rif1 mediates repressive chromatin states to regulate both transcription and DNA repair outcomes. My preliminary work and an array of unique cell lines and molecular reagents developed by my host laboratory, provide me with a unique and timely opportunity to examine this fascinating protein, and develop a better understanding of potentially common regulatory mechanisms that govern transcription
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Providing cutting edge cancer research services across Europe'.

assistant: **Concept**

canSERVs mission is to make cutting-edge and customised research services available to the cancer research community EU wide, enable innovative R&D projects and foster precision medicine for patients benefit across Europe. By connecting, coordinating, and aligning existing oncology and complimentary research infrastructures (RIs) and providing services in a synergistic way transnationally, canSERV will capitalise on the critical mass of experts and cutting-edge services offered by canSERVs RIs and their extended network. canSERV brings together world-class European life science RIs (BBMRI, EURO-BIOIMAGING, ELIXIR, EU-IBISBA, EuroPDX, EU-OPENSCREEN, INSTRUCT, EATRIS, INFRAFRONTIER, EMBRC, ECRIN, EATRIS, MIRRI, ARIE, CCE, EORTC and IARC) that collectively not only covers all aspects along the development pipeline for oncology, but is also capable of interconnecting these technologies providing users a guidance for navigating them through the entire translational value chain.  A patient organisation or resp. governance board members will bring the patients perspective, while the PNO Innovation and PNO Life Sciences & Health will provide valuable input regarding stakeholder engagement, and project management activities.A common access management system (CAMS) will be developed based on mature solutions from INSTRUCT and BBMRI. The CAMS will provide a method for selection of services, construction and submission of research proposals, multi-step review of research proposals, and tracking of the access process from approval through delivery to conclusion.  Through a united user-intuitive transnational access where a united catalogue of oncology services will be offered, our users will have access to a comprehensive service portfolio. As our ambition is to scale up canSERV to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'BRinging Alternative INdicators into POLicy' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

In the last four years, Beyond GDP indicators have rapidly risen up the political agenda and enjoyed greater public awareness. High profile initiatives have included nef’s Happy Planet Index, launched in 2006, the EU’s Beyond GDP initiative – starting with the Beyond GDP conference in 2007, the OECD’s Measuring the Progress of Societies project, and in 2009, the publication of the recommendations of the Commission on the Measurement of Economic Performance and Social Progress, led by economists Stiglitz, Sen and Fitoussi.Despite a growing number of critiques of GDP, and the emergence of an impressive array of alternative indicators, GDP maintains a central place amongst policy makers, planning offices, media and other target groups. Some data on what may be considered Beyond GDP indicators are being collected by official statistics offices, but they appear not to be considered in policy making or are given a peripheral role.The central assumption of the project is that indicators, if effectively embedded in the policy making process, are an effective transmission mechanism to connect research and policy. The aim of the project is therefore to enhance and speed up both the development and the effective use of indicators that can balance the use of GDP so as to support the sustainable development policy process in the EU.Ideally, indicator users need to be aware of the knowledge that exists, and vice versa indicator producers need to be aware of the context(s) in which the indicators will be used. Indicators should be developed as part of an interactive process with multiple feedbacks that ensure that user demands are taken up in the production of alternative indicators. Besides this knowledge gap, it needs also to be understood as part of a change process, in which one h