RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Transport related Air Pollution and Health impacts – Integrated Methodologies for Assessing Particulate Matter' (TRANSPHORM).

assistant: **Concept**

TRANSPHORM brings together leading air quality and health researchers and users to improve the knowledge of transport related airborne particulate matter (PM) and its impact on human health and to develop and implement assessment tools for scales ranging from city to Europe. Over four years, TRANSPHORM will aim to develop and implement an integrated methodology to assess the health impacts of PM air pollution covering the whole chain from emissions to disease burden. The objectives will be: (i) To improve our understanding of transport sources of size-resolved and speciated PM air pollution including non-exhaust, shipping, aviation and railways; (ii) To improved emission factors of ultrafine particle number (PN0.1) and mass fractions of PM1, PM2.5 and PM10 for key transport sources; (iii) To conduct targeted measurements in Rotterdam, Helsinki and Thessaloniki for source apportionment, exposure assessment and model evaluation; (iv) To quantify exposure to airborne PM in urban environments resulting from traffic, road, shipping, rail and aviation; (v) To improve and integrate air quality dispersion and exposure models for urban and regional scales including long-range transport; (vi) To develop new concentration-response (CRF) linking long and short-term ambient residential exposure to size-resolved and speciated PM with key health endpoints; (vii) To develop and implement integrated assessment tool to investigate and analyse the whole chain of processes for selected cities and Europe; (viii) To incorporate micro-environmental PM concentrations, time-activity patterns, and estimates of internal dose into the health impact assessment; (ix) To conduct integrated health assessment of selected European cities; (x) To design and implement mitigation and adaptation strategies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Hydration lubrication: exploring a new paradigm' (HYDRATIONLUBE), addressing dissemination and exploitation.

assistant: **Impact**

In recent years, as first established in some 6 papers in Science and Nature from the PI s group, a new paradigm has emerged. This reveals the remarkable and unsuspected - role of hydration layers in modulating frictional forces between sliding surfaces or molecular layers in aqueous media, termed hydration lubrication, in which the lubricating mode is completely different from the classic one of oils or surfactants. In this project we address the substantial challenges that have now arisen: what are the underlying mechanisms controlling this effect? what are the potential breakthroughs that it may lead to? We will answer these questions through several interrelated objectives designed to address both fundamental aspects, as well as limits of applicability. We will use surface force balance (SFB) experiments, for which we will develop new methodologies, to characterize normal and frictional forces between atomically smooth surfaces where the nature of the surfaces (hydrophilic, hydrophobic, metallic, polymeric), as well as their electric potential, may be independently varied. We will examine mono- and multivalent ions to establish the role of relaxation rates and hydration energies in controlling the hydration lubrication, will probe hydration interactions at both hydrophobic/hydrophilic surfaces and will monitor slip of hydrated ions past surfaces. We will also characterize the hydration lubrication properties of a wide range of novel surface systems, including surfactants, liposomes, polymer brushes and, importantly, liposomes, using also synchrotron X-ray reflectometry for structural information. Attainment of these objectives should lead to conceptual breakthroughs both in our understanding of this new paradigm, and for its practical implications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Membrane Potential and Stem Cell Potency in Normal and Malignant Tissues' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The studies proposed in the current application seek to answer a critical question hindering progress in the early detection and treatment of cancer: How is normal differentiation and lineage commitment disrupted in the earliest stages of cancer development?  As a first step to answer this question we have generated a multi-organ mouse cancer and lineage tracing model by recombining conditional oncogene, tumour suppressor gene and lineage tracing alleles in cells expressing Cre-recombinase from the Promin1 locus: Promin1 marks stem and progenitor cells in several organs. Focusing on the gastric mucosa we showed that this tissue is regenerated by normal Promin1 stem cells and forms gastric cancer when Kras and Tp53 mutations are introduced into these cells.  Remarkably, comparison of the transcriptomes of normal and malignant Promin1+ gastric stem cells revealed a selective silencing of ion channels and solute carriers in the malignant stem population. One of these genes, Nalcn, encodes the ion channel responsible for the resting membrane potential of cells.        Here, I will test the hypothesis that ion-channel regulated membrane potential dictates normal and gastric cancer stem cell differentiation capacity.  To do this I will employ our newly developed conditional allele of Nalcn to alter membrane potential of normal and malignant gastric stem cells in vitro and in vivo.  The effects of Nalcn modulation in gastric stem cells will be evaluated with developmental, histological, transcriptomic, ex vivo stem cell and electrophysiological studies. Specific Aim 1 focuses on the expression and impact of membrane potential in normal stem cells while specific Aim 2 probes the role of Nalcn expression on tumour formation.  The results of these studies will contribute fundamen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Stacks and Categorification' (STACKSCATS), addressing dissemination and exploitation.

assistant: **Impact**

This proposal will support the applicant as a research fellow at the Mathematical Institute, Oxford University, for two years. The proposal has two objectives.Objective 1 is a joint project with the proposed host scientist, Professor Dominic Joyce. It studies the moduli stacks of coherent sheaves on a Calabi-Yau (C-Y) 3-fold. C-Y 3-folds are a major focus of research in Geometry and String Theory in Mathematical Physics. Donaldson-Thomas (D-T) invariants ""count"" coherent sheaves on C-Y 3-folds, and are interpreted in physics as numbers of ""B-branes"" or ""BPS states"". The host scientist Professor Joyce is well-known for his work on  D-T theory.  Objective 1 studies foundational properties of moduli stacks of coherent sheaves on C-Y 3-folds, which must be understood to extend D-T theory in several directions: ""categorified"" D-T invariants, extensions to fields other than the complex numbers, and D-T theory for the derived category. We will explore when moduli schemes (and atlases for moduli stacks) can be written as critical loci of holomorphic functions, find an algebraic substitute for this which works over other fields, and apply to Behrend functions and properties of D-T invariants.Objective 2 is a joint project with Oxford faculty member Dr Kobi Kremnizer. It aims to categorify the Verlinde algebra in a novel way using categories of twisted equivariant coherent sheaves on algebraic groups, and to use these to construct a new family of 0-1-2-3 Topological Quantum Field Theories.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Facilitating Implementation of Research Evidence' (FIRE).

assistant: **Concept**

Facilitating Implementation of Research Evidence (FIRE) is a proposed four year programme of research to identify and validate key factors determining the successful implementation of research evidence in practice. The study is underpinned by a conceptual framework, the Promoting Action on Research Implementation in Health Services (PARiHS) framework, which proposes that the successful implementation of research evidence is dependent on the complex interplay of the evidence, the context of implementation and the way the process is facilitated. The planned research will focus on evaluating the feasibility and effectiveness of facilitation as an implementation strategy. A randomised, controlled trial with three intervention arms (standard dissemination and two different models of facilitation) and six units in each of five countries (four in Europe, plus Canada; n=30) is planned. The units will be asked to implement research based guidance on continence promotion and receive differing levels of facilitation support to do so. Detailed contextual, process and outcome data will be collected to fully explore the complex processes at work during implementation. With the combination of an international consortium and experienced research team, a theory-driven, multi-method evaluation study and detailed attention to stakeholder involvement and dissemination throughout the research, the study has the potential to make a significant contribution to the knowledge and practice of translating research evidence at a clinical, organisational and policy level, within Europe and internationally.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshes' (MarshFlux) under Horizon 2020.

assistant: **Objectives**

Coastal wetlands are globally important ecosystems providing valuable ecosystem services, such as carbon sequestration over long timescales, affecting global carbon cycling and climate modulation. The amount of carbon sequestered, and therefore the net long-term global cooling potential of coastal marshes, however, is affected by complex biogeochemical reactions in marsh soils, which may produce and/or consume all three of the major greenhouse gases (GHGs) (carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O)). The magnitude and direction of these fluxes, and whether marsh soils act as a source or sink of GHGs, is affected by a variety of environmental factors which are predicted to vary with projected global change. MarshFlux, therefore, aims to address fundamental gaps in understanding of how the global cooling potential of coastal marshes will be affected by responses of biogeochemical reaction rates and GHG fluxes to global change. The effect of multiple drivers of global change on the response of GHG fluxes and key microbial processes for the consumption and production of N2O and CH4, will be investigated using a novel combination of laboratory incubations and mesocosm experiments. Laboratory incubation experiments mimicking modelled global change scenarios will be conducted to constrain the effects of drivers on marsh soil biogeochemical reaction rates and subsequent GHG dynamics, focusing on temperature, nutrient-loading and salinity. The results of these experiments, while critical themselves, will then inform mesocosm experiments to allow for the assessment of the whole ecosystem (soil, water and vegetation) response to global change under current and predicted future conditions. This research is critical for effective management of coastal wetlands to m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Improving Prognosis by using innovative methods to diAgnose Causes of Encephalitis' (I-PACE) under Horizon 2020.

assistant: **Objectives**

Background: Encephalitis is a severe inflammation of the brain that can be caused by viruses, bacteria and other microorganisms, or autoimmune disease. The impact is high: the case fatality rate is 10-20% and half of patients have neurological deficits. Identifying the cause of encephalitis is essential for early initiation of therapy and thereby improves outcome.The clinical challenge: Current diagnostics for encephalitis are insufficient. My prospective pilot study showed that the cause of encephalitis could be identified in only half of patients. Aim: The aim of I-PACE is to improve the cause-specific diagnosis of encephalitis using innovative diagnostic methods.Methods: I will use my encephalitis network of Dutch hospitals to study innovative diagnostic methods in 3000 patients with suspected encephalitis and validate the results in 2000 patients from Denmark, the UK and Zambia. I will collect clinical data, cerebrospinal fluid (CSF) and blood to enable state-of-the-art diagnostic studies and identify novel causes of encephalitis. First, I will perform virus discovery and DNA metagenomics sequencing to identify new infectious causes of encephalitis, combined with phage-display antibody sequencing. Second, I will perform CSF single cell gene expression studies to identify transcription patterns specific for the cause of encephalitis. Third, single cell immune profiling and anti-neuronal antibody detection assays will be used to identify new causes of autoimmune encephalitis. Finally, I will perform extensive metabolite and lipid analysis in the CSF to identify new biomarkers enabling a syndromic diagnosis to quickly differentiate between causes.Impact: With I-PACE I aim to increase the proportion of patients with a cause-specific diagnosis of encephalitis from 50% to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Minimizing Defects in Micro-Manufacturing Applications' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Micro-manufacturing requires 'Zero-Defect' oriented approaches, both in large scale and in short-run production. Current quality control approaches, coming from macro-manufactring, are mainly based on post-process geometric control, which produces a large time lag between the defect generation and its detection, usually leading to large amount of defect parts (large scale) or wasted high value processing (short run). Moreover, this approach does not immediately point the error source to help with error correction, and other criteria such as material integrity, physical properties, surface topography and piece or component functionality are not taken into account typically.There is clear need for extending the final product validation to a process monitoring approach in micro-manufacturing, where all the manufacturing process is monitored, from the raw material to the fabrication processes and the manipulation of the final parts, and where all this information is processed in real time with suitable models for error prediction, automatic detection and process optimization by system correction.The project will give a global solution for the 'zero defect' approach in micro-manufacturing, with a focus on the aspects that are specific to micro-manufacturing. The develop technologies concepts are expected to have in impact in the competitiveness of the micro-manufacturers in the following ways:- reducing process variability detecting defects as soon as they are generated or in the case that it is possible, are going to be generated by predicting models.- allowing the use of less expensive machines, that can reduce their variability through monitoring.- requiring less skilled working force, thanks to acquired process setting knowledge and the development of smart decision-maki
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Automorphic Forms and Moduli Spaces of Galois Representations', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

I propose to establish a research group to develop completely new tools in order to solve three important problems on the relationships between automorphic forms and Galois representations, which lie at the heart of the Langlands program. The first is to prove Serre’s conjecture for real quadratic fields. I will use automorphic induction to transfer the problem to U(4) over the rational numbers, where I will use automorphy lifting theorems and results on the weight part of Serre's conjecture that I established in my earlier work to reduce the problem to proving results in small weight and level. I will prove these base cases via integral p-adic Hodge theory and discriminant bounds.The second is to develop a geometric theory of moduli spaces of mod p and p-adic Galois representations, and to use it to establish the Breuil–Mézard conjecture in arbitrary dimension, by reinterpreting the conjecture in geometric terms. This will transform the subject by building the first connections between the p-adic Langlands program and the geometric Langlands program, providing an entirely new world of techniques for number theorists. As a consequence of the Breuil-Mézard conjecture, I will be able to deduce far stronger automorphy lifting theorems (in arbitrary dimension) than those currently available.The third is to completely determine the reduction mod p of certain two-dimensional crystalline representations, and as an application prove a strengthened version of the Gouvêa–Mazur conjecture. I will do this by means of explicit computations with the p-adic local Langlands correspondence for GL_2(Q_p), as well as by improving existing arguments which prove multiplicity one theorems via automorphy lifting theorems. This work will show that the existence of counterexamples to the Gouvêa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Light weight feal intermetallic alloy for high efficiency components in transportation and power generation industries (FIAC)' under Fifth Framework.

assistant: **Concept**

This project aims at developing the use of light FeAL intermetallic alloys in substitution to steels and nickel alloys in transportation and power generation industries. Recent works (mainly in Europe) have allowed to solve the traditional problems that have limited the use of these materials until now. Today a European reference alloy is produced at laboratory scale. In this project, industrial manufacturing routes (powder metallurgy, forging...) will be developed. Components will be manufactured then tested in actual conditions. This fabrication will also be evaluated in economical terms. The use of FeAl in substitution to steels and nickel alloys will allow to enhance the efficiency of engines and power generation systems, to reduce weight and thus limit fuel consumption and to improve direct operating costs. Environmental friendliness will be improved through the reduction of pollutant emissions, the reduction of vibrations and external perceived noise, the saving of resources in strategic materials such as nickel and chromium and the limitation of their use as they are now recognized as dangerous for health.