RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Efficient and clean production of electricity from biomass via pyrolyses oil and hydrogen utilizing fuel cells - target action g (BIO-ELECTRICITY)' (BIO-ELECTRICITY), addressing dissemination and exploitation.

assistant: **Impact**

Objectives and problems to be solved:The objectives of the project are to develop and demonstrate the efficient production of hydrogen and electricity, from pyrolysis oil with the integration in stationary electric power and heat production plants in remote, out-of grid-situations (500 kWe) using Molten Carbonate Fuel Cells (MCFC). The development of the integrated fuel processor (consisting of a reforming catalyst, a reforming reactor, a syngas cleaning unit and a fuel cell) is the core issue of the project.Description of the work:The production of H2 and electricity from biomass is accomplished by reformation of bio-oil produced in fast pyrolysis processes, which are mature and of nearly commercial status. Processes for the reformation of pyrolysis oil to H2, and suitable for the production of electricity and heat (cogeneration) in small-to-medium size stationary applications, are optimised with respect to appropriate reactor configurations and efficient catalytic materials. A hydrogen rich process gas will be produced, also containing CO and CO2. The water-gas shift reaction transforms residual carbon monoxide into H2 and CO2. Optimal catalytic materials for these reactions will be developed, exhibiting high activity and selectivity towards H2 production and enhanced stability with time on stream, and they will be incorporated into proper reactor configurations. Each component of the process (fast pyrolysis of biomass, steam reforming of bio-oil, water-gas shift reaction, hydrogen-rich gas upgrading, fuel cell testing), will be considered separately, and integrated to a complete fuel processing system suitable for a prototype power production unit of 5kWe. An economic evaluation of the process is carried out for a 500 kWe commercial scale unit.Expected Results and Ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Relationships between recent changes of growth and nutrition in Norway spruce, Scots pine and european beech forests in Europe' under Fourth Framework.

assistant: **Concept**

Recent changes of forest growth and of site conditions reported for many European forests emphasize the necessity for investigation of the interrelationships between forest growth, stand nutrition and site fertility. The main objective of the proposed research project is to identify and quantify the relationships between recent changes in forest growth, stand nutrition and environmental changes including those of site fertility on the European level. This activity is directly relevant to the research tasks of the FAIR Work Programme item 4.5.2 'The functioning of the forestry ecosystem'. The specific objectives of the project are: and to investigate their interactions with focus on the relative importance of nutrients (primarily nitrogen and CO2), climate (primarily temperature and precipitation), and land-use changes; availability of historical data allow the testing of specific hypotheses about causes of changes in site productivity; sustainability and to assess the implications of future management strategies. Two primary approaches have been chosen in order to analyze the problem: a multivariate, correlative approach, and a mechanistic, modeling approach. With the first approach, local and regional relations between tree growth, climate, stand nutrition and site fertility will be looked for. The mechanistic modeling approach will allow the verification of relationships found with the correlative approach, as well as to analyze the relative importance of the major factors affecting tree growth. An important task will be to quantify the changes in productivity in relation to the strength of the determining factors. Scenario analyses of possible future changes in site productivity and forest stability under changed climatic and deposition conditions are another importa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Protecting against obesity-induced chronic kidney disease using pro-resolving lipids'.

assistant: **Concept**

This project will explore the therapeutic potential of pro-resolving lipids in obesity-induced chronic kidney disease (CKD). The experienced researcher is Dr. Emma Börgeson and the mentors are Prof. Kumar Sharma (outgoing, University of California San Diego, USA) and Prof. Catherine Godson (return, University College Dublin, Ireland).‘The epidemic of obesity poses one of the most serious public health challenges in the WHO European Region’ (WHO, 2006). Obesity is associated with chronic systemic low-grade inflammation. Failure to resolve this inflammation leads to development of associated complications such as CKD. The resolution of inflammation is actively regulated by endogenous pro-resolving lipid mediators, e.g. lipoxins (LXs) and resolvins (Rvs).We hypothesise that 1) Pro-resolving lipids prevent obesity-induced adipose inflammation and thereby subvert kidney disease, 2) Humans developing obesity-related pathologies have impaired endogenous production of pro-resolving lipids. To investigate this we will assess the protective effects of pro-resolving lipids in animal models of obesity-induced kidney disease and elucidate the cellular signalling pathways involved (outgoing phase). We will correlate our findings to human obesity and investigate if development of obesity-related pathologies reflects an impairment of endogenous production of LXs and Rvs (return phase).The synergy between Prof Sharma (expertise; obesity, CKD) and Prof Godson (expertise; inflammation, CKD) will provide a unique research opportunity to combine state of the art facilities and innovative research methodology. Dr. Börgeson will acquire significant technical skills, an international network as well as management, teaching and outreach experience. The fellowship will enhance her ability to sec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DATA ANALYSIS SOFTWARE FOR THE ATLAS EXPERIMENT' to be submitted under Sixth Framework.

assistant: **Abstract**

The research objective of the project encompasses a direct contribution to the development of the ATLAS data analysis software. The applicant would participate strongly in the preparation of the ATLAS Data Challenges and in the validation of the ATLAS Computing Model, which is based on GRID technology. Part of the project will be to participate in the development of the offline reconstruction software and of the software infrastructure needed for the physics analysis. The conclusion of her work will be the demonstration of the full ATLAS data analysis chain in a large-scale GRID production and the subsequent physics validation of the results. Thereby her work will be an important element in the effort to verify the technology and design choices, with the aim to ensure the full physics potential of ATLAS. In the ATLAS Computing Model the trigger processor farms located at the experiment will reduce the initial event rate of 1^9 Hz down to a 100 Hz using software reconstruction and selection algorithms. The subsequent analysis of the output data volume of 1 Pet byte (10^15 bytes) per year produced by the ATLAS experiment requires new methods of data reduction and analysis. State-of-the-art GRID technology will provide the means to store, access and analyse the data in a worldwide collaborative effort. Highly specialised detector reconstruction software will be used to analyse the raw data and to extract the relevant information in form of AOD, Analysis Oriented Data, which comprises both, detailed detector information like energy deposits in the calorimeter and physical objects in the event such as the number of jets, electrons or moons. Subsequently a dedicated data analysis framework will be used by the 2000 ATLAS scientists to access the AOD and to analyse the events u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'ERA-NET ROAD II'.

assistant: **Concept**

ERA-NET ROAD II’s aim is to strengthen the European Research Area in road research by coordinating national and regional road research programmes and policies. The consortium comprises owners and managers of road research programmes in fifteen countries and two regions, i.e. the eleven National Road Administrations active in the first ERA-NET ROAD plus four more National Road Administrations and two Regional Road Administrations. Jointly, they will promote, develop and facilitate collaborative trans-national programming, financing and procurement of road research. ERA-NET ROAD II intends to build on the success of the first ERA-NET ROAD, which was funded under the Sixth Framework Programme. It made considerable progress towards the networking of road research programmes across Europe and was able to develop working procedures, identify common strategic research opportunities and launch a number of joint trans-national research projects. ERA-NET ROAD II will build on that work, focusing on implementation of joint activities and funding of joint trans-national research. The partners in ERA-NET ROAD II will ensure that coordination between road research programmes owners from both within and outside the Consortium is broadened and deepened, and new partners will be invited to join the consortium. Two trans-nationally funded programme calls will pave the way towards achieving an expenditure of 10% of public road research budgets on collaborative research by 2013. The project will also liaise with other public and private stakeholders in transport research programming in Europe and encourage collaboration with non-European research programmes. At the end of the project, collaborative research will have become “business as usual” for National Road Administrations. A permanent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecule for low diffusion TPCs for rare event searches' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

One of the most promising technologies to search for neutrinoless double beta decay (0nubb) is a high pressure xenon gas (HPGXe) time projection chamber (TPC) with electroluminescent (EL) amplification. The key advantage of an EL HPGXe TPC is the capability to uniquely image the track of the two emitted electrons in a 0nubb event, together with high energy resolution. The current imaging performance is limited by the diffusion of the ionization electrons during drift. This proposaldescribes a research program to reduce diffusion by adding CH4 molecular additives to the xenon gas toimprove the imaging capability in an EL HPGXe TPC enhancing the sensitivity to the 0nubb decay, within the context of the NEXT collaboration. Dr. Lopez March and the two supervisors Prof. Gomez Cadenas and Prof. Nygren propose to develop the project in two stages: 1) characterization of the CH4 molecular additive in a small detector at the University of Texas at Arlington (UTA),  Outgoing Phase); 2) exploit the new gas mixture to perform the measurement of the topological signature with the NEXT-DEMO TPC at the Instituto de Fisica Corpuscular (SPAIN) and with the NEW TPC at the underground Laboratorio Subterr\'aneo de Canfranc (LSC) (Return Phase). The objectives of the MELODIC project have been planned to boost the career development of the fellow. The overall training received by Dr. Lopez March in the proposed research project will give her independence and professional maturity. She will become a truly, multidisciplinary researcher capable of integrating different areas of research (operation of detectors and physics data analysis) making her uniquely trained for leading her own line of research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'bLadder cAncer URine cEll aNalysis'.

assistant: **Objectives**

Bladder cancer is the 4th most common cancer in men and the 7th in women, with 330,000- 380,000 new cases annually worldwide or more than 150,000 in Europe and is one of the most expensive cancers to manage.  Bladder cancer incidence is strongly related to age, with the highest incidence rates being in older men and women. Cystoscopy/cystoscopic biopsy remains the current gold standard diagnostic and monitoring tool. This procedure is highly invasive and expensive - costing up to €1200 per test - and has been reported to miss in the region of 25% of all bladder tumours.  As an adjunct to cystoscopy, urine cytology is routinely carried out globally but its deficiencies in terms of poor cancer detection (low sensitivity) are well recognised and reported.  The overall objective of the LAUREN project is to provide a commercial non-invasive in vitro diagnostic that will significantly reduce the management cost of caring for bladder cancer patients, whilst at the same time improving patient comfort and reducing morbidity associated with current invasive procedures.  The specific diagnostic is based on the MCM2 + Immunofluorescence biomarker for bladder cancer cells found in urine.The scope of the project is to complete the final development, validation and regulatory activities required to prepare a novel the new diagnostic for the market.The objectives of the project are to:PO1  Clinically validate the biomarkers including the addition of Immuno Fluorescence PO2  Complete development of and validate a single use cell collection device,PO3  Validate the cell recognition software for regulatory acceptancePO4  Validate the software of an automated slide analysis system.PO5  Prepare a complete evidence package to support obtaining a CE Mark and FDA approval for commercialisation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Exploiting the activity of the ALDH enzyme to develop highly selective drugs for cancer stem cells' (SeleCStem), addressing dissemination and exploitation.

assistant: **Impact**

Despite huge advances in cancer treatment, resistance to chemotherapy is still common. It is now well established that a small population of cells named cancer stem cells (CSCs) have high tumorigenicity and are able to initiate and maintain a tumour. CSCs usually remain in a quiescent state that is not affected by standard chemotherapy; thus, they are often responsible for treatment resistance and relapse. There is a clear need to find effective treatments against CSCs to fully eradicate the tumour. However, the close similarities of CSCs to healthy stem cells hinders the identification of selective drugs.In the last years, new drug modalities are emerging to provide therapeutic options for challenging targets and diseases, expanding the drug discovery landscape. In line with these trends, SeleCStem aims to develop innovative chemical biology strategies to target CSCs in a safe and effective manner. It will exploit the activity of the enzyme ALDH, which is overexpressed in CSCs of many cancer types, to obtain selective drugs using three orthogonal strategies: we will use the oxidoreductase activity of ALDH to trigger the selective (1) accumulation or (2) release of drugs inside CSCs and (3) use external light to inhibit ALDH only in the tumour area. Successful strategies will be combined at the end of the project to overcome potential limitations of the individual approaches, hence massively increasing the drugs’ selectivity and efficacy. We will design these molecules with the aid of docking studies, synthesise them, and assess their ALDH- or light-triggered activation in purified enzyme assays and in CSC spheres.Overall, we will develop the proof of concept of unprecedented approaches to eliminate CSCs with outstanding precision, thus overcoming some of the limitation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Exploitation of microbial biodiversity for the discovery and development of novel cosmeceutical agents'.

assistant: **Innovation**

MICROSMETICS aims to discover and carry to the stage of development innovative products in the area of cosmeceuticals originating from global biodiversity using emerging and state of the art technologies in the field of biotechnology, natural products chemistry and applied microbiology. These objectives will be implemented through an extended and balanced scheme of researcher’s exchanges and recruitments, in both directions and via a mutual scientific project developed on the needs and interests of both Industrial and Academic sectors, exploiting the existing complimentary expertise. More specifically, MICROSMETICS scientific concept involves the discovery of novel natural products originating from global microbial biodiversity. Already existing culture collections will be exploited incorporating modern high throughput platforms (in silico & in vitro) for the rational and targeted selection of the most promising strains. Advanced analytical approaches and techniques will be applied for the efficient, accelerated and advantageous isolation and identification of natural constituents as well as the quality assessment of the lead products.  A broad spectrum of bioassays and novel analytical approaches will be incorporated for the evaluation of anti-ageing, more specifically anti-oxidant, skin-protecting, and skin-whitening activity of all derived products. Attention will be given to the selection and optimisation of fermentation technologies used for the production of final lead products to ensure sustainability. Within this frame, core scientific knowledge and lead compounds for further development are expected to be produced creating valuable synergies. Expertise will be transferred by means of the seconded researchers training in environments with different dynamics and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Conditional inactivation of Notch signalling during myogenesis by development and application of Pax7 specific transgenic mouse models' in the context of a Sixth Framework call.

assistant: **Objectives**

Determination of the complex cause and effect signalling pathways that lead from pluripotent precursor cells to differentiated tissue is a critical topic that impacts on the development of effective stem cell therapies. Notch signalling is important for many cell fate decisions, however for myogenic progenitors clear genetic proof is still required.Because Notch mutants are embryonic lethal, we aim to develop a conditional inactivation system utilising Cre/lox murine transgenesis. We will introduce Cre recombinase expression under control of native Pax7 control elements as this gene defines the embryonic myogenic lineage and adult muscle satellite cells.We will also use the Tet-On system to allow temporal control of Cre-mediated recombination. By crossing these Cre-expressing lines with mice carrying floxed alleles of Notch1 and its downstream effector RBPJk, we will be able to inactivate these genes in embryonic myogenic precursors and adult muscle satellite cells.Whilst this transgenic approach is underway we will also conduct a collaborative in vitro side project whereby protein extract from cultured in vitro myoblasts are affinity captured to identify interactors for a previously identified critical E-box transcriptional binding site located in the Myf5 promoter.Overall, our transgenic approach will provide the means to determine the role of Notch signalling in myogenic precursor cell development in the embryo and adult.The Pax7 specific Cre expressing transgenics will also provide a tool that we will be able to apply to other gene targets in myogenesis, which will help resolve the pathways essential to myogenic cell fate determination. Additionally, we will be investigating potential new regulators of Myf5 in vitro.