RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hypnodelic therapy: the benefits of hypnosis know-hows for psychedelic therapy' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In recent years we have witnessed a renewed interest in psychedelic-assisted psychotherapy (PAP). The psychedelic compound ketamine, a N-methyl-D-aspartate glutamate receptor antagonist, shows potential for the treatment of depression and addiction. Key psychological mechanisms underlying these effects of PAP are the suggestions by the therapists and psychedelic-induced mystical experiences. Currently, the mechanism of suggestibility in PAP is receiving more attention as it is hypothesized that all psychedelics increase suggestibility – a topic that so far has been studied mostly in the field of hypnosis research. At a neurobiological level, the predictive processing framework suggests that ketamine induces its effects by disrupting the brain’s predictive functioning. In the context of the renaissance of psychedelic research, this project proposes to leverage the practical know-how on suggestibility from hypnosis research to investigate the intriguing interplay between suggestibility, hypnotic suggestions, and the psychedelic experience within the predictive processing framework. Our study has 4 aims: 1) assess suggestibility under ketamine; 2) assess hypnotic suggestions’ impact on the phenomenology of the psychedelic experience; 3) assess if a hypnosis- and ketamine-induced mystical experience leads to improved mental well-being, and 4) validate the predictive processing framework. We will conduct a crossover randomized double-blind placebo-controlled study with a 1-month follow-up, including 36 healthy participants and 2 conditions: Hypnodelic (ketamine + hypnotic suggestions) and Hypnocebo (placebo + hypnotic suggestions). We will measure suggestibility, mystical experience, and predictive processing through quantitative, qualitative and neurophysiological analyses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'GeoTraceability Integrated System for Common Agricultural Policy'.

assistant: **Innovation**

The aim of GTIS CAP is to define and to validate an integrated information system that will serve both the European and national administrative bodies in charge of the Common Agricultural Policy and the producers of vegetal produce for consumers and for livestock. GTIS CAP will complete the IACS/LPIS data with other data obtained from remote sensing and will define simple geo-traceability indicators aimed at the management, control and monitoring of the CAP and which can also be used in integrated agricultural management systems. GTIS CAP will facilitate online access to this geo-traceability data and will ensure greater efficiency in checking and conformity of good agricultural practices, in line with CAP recommendations.The GTIS CAP project comprises four different types of work: 1.The evaluation of new functionalities necessary for the integration of geo-traceability into existing tools and for it to become a CAP management, follow up and monitoring tool which will also be useful for producers. 2.Definition of norms and standards that will enable the interoperability of IACS/LPIS geo-referenced data and functionalities for CAP management, follow up and monitoring. 3.Definition of simple and easy-to-use geo-indicators provided by satellite images. 4.Implementation and validation of the integrated system in two test regions in order to produce after experimentation by producers groups a recommendation for European and national administrative bodies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Next-gen Liquid Chromatography - Mass Spectrometry Technology for Unravelling the Plasma Proteome' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

NEXT-UP involves the development of a cutting-edge proteomics analytical platform for untargeted mass spectrometry (MS) based proteome profiling doubling the chromatographic resolving power and delivering an unprecedented three-order magnitude increase in MS detection sensitivity. Key technological advancements include the development of a new generation of precision-engineered monolithic capillary columns, designed with a nanostructured flow-through pore system, which is compatible with ultra-low-flow (<20 nL/min) operation. In addition, an innovative microfluidic modulator chip will be designed and constructed to enable sample transfer in two-dimensional liquid chromatographic (2D-LC) separations on a nanoflow scale. Proof-of-Concept involves the comprehensive identification of plasma protein signatures in serum. Consequently, the NEXT-UP initiative aims to unravel plasma proteomics by revealing high-impact, low-abundance proteins, with the goal of advancing early disease detection,  uncover disease mechanisms, and revolutionizing personalized treatments. The project will be conducted at the VUB having unique expertise in biocolumn and chip design/prototyping and nanoLC-MS omics in close collaboration with HZI providing relevant samples and knowhow in clinical (plasma-) proteomics, bioinformatics/statistics matching the demands in translational research and systems level approaches.


**Keywords:** separation science,  serum proteomics,  two-dimensional liquid chromatography
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Singular Stochastic Dispersive Dynamics' (SingStocDispDyn).

assistant: **Concept**

This proposal is concerned with the study of singular stochastic dispersive partial differential equations (PDEs), broadly interpreted, with stochastic forcing and / or random initial data. This is a young emerging field, attracting more and more attention. In recent years, we have witnessed outstanding advances in the theory of singular stochastic parabolic PDEs. Our understanding of the dispersive counterpart is, however, much poorer. The main objective of this proposal is to develop novel mathematical ideas and tools and fundamentally advance our understanding of singular stochastic dispersive PDEs by working on concrete examples of challenging open problems.Over the last ten years, there has been significant progress at the interface of dispersive PDEs and stochastic analysis and I have been one of the leading mathematicians in this development. In particular, my recent work on the three-dimensional stochastic nonlinear wave equation (NLW) with a quadratic nonlinearity has opened up new research horizons, which we will explore in this proposal.1. We will investigate the well-posedness issue of the three-dimensional (damped) stochastic cubic NLW with an additive space-time white noise. The solution theory for the parabolic counterpart (the so-called stochastic quantisation equation) was settled by Hairer (2014). The corresponding question for the wave equation is one of the major open questions in this field. We will develop a paracontrolled approach to solve this challenging open problem. Moreover, we address other related problems of independent interest, including the two-dimensional hyperbolic sine-Gordon model, diffusive scaling limit of damped stochastic NLW and singular stochastic nonlinear Schrdinger dynamics.2. We will also build a pathwise solution theory f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Technology-driven combinatorial therapy to rewire the spinal cord after injury'.

assistant: **Innovation**

ReWIRE will combine innovative translational neurotechnologies and rehabilitation interventions for the repair and restoration of neurological functions following injury of the spinal cord (SC). The proposed research program will equip next-generation scientists with unique skills to develop disruptive therapeutic solutions for patients with paralysis. Recent technological breakthroughs have triggered a paradigm shift in the conception of therapies aimed to restore function after spinal cord injury (SCI). Novel drug delivery systems and biomaterial bridges have been engineered to reduce secondary injury and scarring, to stimulate and guide regenerating nerve fibres across the lesion site, and to promote functional reconnection with intact tissue. Additionally, neuromodulation therapies can reactivate spinal circuits below a SCI, allowing people with chronic paralysis to regain voluntary control of walking. In conjunction with rehabilitation, neurological recovery was promoted that persisted without neuromodulation, suggesting a rewiring of the SC as demonstrated in preclinical models. To bypass an injury, neuromodulation has been linked to brain signals to re-establish cortical control over spinal circuits by employing electrical nerve stimulation and robotic systems. Advances in robotics are significantly augmenting the impact of neurorehabilitation by inducing new natural “wired” connections. The aim of ReWIRE is to leverage all these technical and therapeutic breakthroughs in the framework of multiple PhD projects that will continuously interact to converge toward effective combinatorial treatments for SCI. ReWIRE will focus on three inter-woven objectives: i) establish an international, interdisciplinary, and intersectoral educational network, ii) build an SCI clini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Matched Sampling Approaches for Statistical Inference in Large-Scale Clinical Neuroimaging Studies' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Noninvasive neuroimaging techniques have shown much promise over the last decade in the investigation, diagnosis and in determining treatment of neurological disorders. However, to improve their predictive power and better understand underlying causative disease factors it will be essential to extend our investigations to empiric studies of large populations and to develop appropriate statistical models and define statistical procedure for use in such observational studies. It is the main objective of this project therefore, to develop and extend the methods of Causal Inference for use on large unstructured neuroimaging datasets. Specifically, this proposal seeks to 1) Develop and apply existing techniques from matched sampling to observational studies of imaging for Causal Inference. 2) Investigate the benefits of the same matched sampling procedures in support of classification models. 3) Industrial considerations: This is an enterprise panel proposal and will aim to integrate the developed technology into the Clinical Imaging Big-Data program at Siemens HealthCare (SHC), Erlangen. These objectives will be achieved by implementing and testing different Matched Sampling procedures using large observational neuroimaging datasets and assessing their performance through reduction in the specific forms of bias known to be present in observational data. These methods will be extended for use in classification models and the effects of matching on common prediction methods will be examined. The project is highly relevant for the work program as it will provide an opportunity to enhance training through Siemens and has the potential to facilitate a career move from academia to the non academic sector.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'OPTIMISING COLORECTAL CANCER PREVENTION TROUGH PERSONALISED TREATMENT WITH ARTIFICIAL INTELLIGENCE' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Integration of artificial intelligence (AI) technologies into clinical medicine has been hampered by challenges related to uncertain long-term clinical benefits, cost-effectiveness, and ethics/legal concerns. Application of AI in colonoscopy, a forefront research topic, has been also bothered by these issues. AI is, however, expected to reduce colorectal cancer incidence and mortality through personalised treatment. Our proposed project would change this discouraging situation and thus drastically improves colorectal cancer care. We achieve the following goals:    1. Establish the value of AI-assisted colonoscopy in colorectal cancer prevention by conducting a pan-European,        population-based, randomised trial with 222,000 participants.   2. Develop a colonoscopy AI risk-prediction tool for personalized treatment of colorectal polyps and cancer.    3. Develop cost-effectiveness models of AI-assisted colonoscopy in colorectal cancer screening.   4. Investigate ethical and legal barriers in AI development and implementation.   5. Generate the first trustworthy and rapidly updating (?living?) clinical guidelines for AI in screening colonoscopy.   6. Develop a patient-oriented AI tool by including end-users in the process of AI development and communication. Our research consortium maximises the feasibility of the project, with world-class experts in gastroenterology, machine learning, cancer screening, biostatistics, disease modelling, regulatory science, and ethics and law in medicine from nine European countries, the US and Japan. We also partner with a European medium-size AI enterprise for implementing the output of the project. The project has large potential impact on patients, society, and economy in Europe, and the World. Up to 6,000 fewer deaths due to colore
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Euro-marmoset group' (1998-2002).

assistant: **Concept**

The European Marmoset Research Group (EMRG), a nonprofit organisation, was established in 1994 to facilitate inter-disciplinary communication between institutions - academic and industrial - conducting biological and/or biomedical research with primates. A major goal of the EMRG is to optimise the use of marmosets and tamarins as subjects in a wide range of life science disciplines. The EMRG has published a Handbook of Marmosets and Tamarins in Biological and Biomedical Research (1997), produces a biannual newsletter, and organises annual workshops.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New MCMC-Enabled Bayesian Statistical Methods for Complex Data and Computer Models in Astronomy' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This proposal aims to develop a new model-based strategy for statistical problems in astronomy involving complex computer models. It embeds computer models into multilevel models in order to explicitly account for complexities in both astronomical sources and in new high-tech telescopes with the aim illuminating the underlying physical processes. Specific methods will be developed to account for calibration uncertainty in X-ray detectors. This involves emulating a computer model for the calibration product and embedding it into a larger model for the detector and the astronomical source. The result will be a dramatic improvement in the assessed uncertainty in fitted parameters, a reduction in false positives and false negatives, and improved robustness of meta-analyses of populations of sources. Methods will also be developed for fitting stellar evolution models. This involves linking multiple computer models via parametric bridges and embedding them into a statistical likelihood. The increased precision of fitted stellar parameters will enable astronomers to identify stellar subpopulations, to study now hidden aspects of Galactic evolution, and to test and refine the physics underlying the stellar evolution models.  A final set of new models will better link supernova light curve data with cosmological parameters, thus helping to unlock the secrets of the formation and evolution of the Universe. Since model misspecification can have a serious adverse affect on scientific findings, especially with such complex models, a suite of new model checking and selection techniques will be studied. With his substantial experience developing state-of-the-art scientific computation, advanced methods for statistical inference, and careful model checking procedures, especially in ast
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Probing the role of human beta-glucosidases in the metabolism of dietary phytochemicals.' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

To determine the effects of beta-glycosidase on the bio availability of dietary photochemical as a likely rate limiting step in metabolism/uptake. This will combine the use of human cell lines and heterogonous expression system for structure-activity relationships with detailed metabolites analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Photonic-plasmonic hybrid for optical switching and biosensing application' (PHOTON-PLASMONHYB) under Seventh Framework.

assistant: **Objectives**

The main objective of this proposal is on exploring the synergy of the two cores of nanophotonics technologies, i.e., silicon photonics and plasmonics, which have been identified as one of the key competitiveness of European research and economic sectors. [The Leverage Effect of Photonics Technologies: the European Perspective. By European Commission]The project addresses hybrid structure composing of a silicon microring (MR) or microdonut (MD) resonator coupled with a plasmonic nanoantenna. The presence of the nanoantenna, with its controllable and enhanced local electromagnetic fields, will allow controlling the optical properties of MR or MD via near-field coupling, but which is achievable through far-field excitation. Many degrees of control over the optical property of the MR or MD are achievable via the polarisation state of the far-field source, and size, shape, orientation and placement of the nanoantenna with respect to the MR or MD. The underlying physics behind the photon-plasmon coupling will be investigated with an aim of achieving design rules for photonic-plasmonic hybrid structure. Furthermore, the proposed hybrid structure will be demonstrated for use as an optical switch and a biosensor.The generated research outcomes will be relevant to the EU in two main respects: first, they will help advance the fundamental knowledge concerning the physics behind the coupling between silicon photonic structure and plasmonic nanoantenna, which will strengthen the position of EU as the world’s leader in the field, towards making it the hub of scientific research and, second, the design has potential for intellectual property protection, thus, enhance EU’s industrial competitiveness  by giving its an edge in the marketplace.