RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New-generation cardiac therapeutic strategies directed to the activation of endogenous regenerative mechanisms' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Heart failure is a major epidemic world-wide, resulting in a large burden for society in deaths, morbidity and economic sustainability. The inability of the human heart to regenerate the myocardium lost due to acute myocardial infarction underlies a large part of chronic heart failure cases. To tackle this problem, REANIMA aims to deliver new therapies for heart regeneration, thereby reverting the conditions that lead to heart failure. Thus far, clinical trials based on introducing stem cells into the heart have not shown regenerative ability. In contrast, studies of spontaneous and induced heart regeneration in animal models strongly suggest a change in paradigm towards the reactivation of endogenous regenerative mechanisms. To develop this new path, REANIMA presents the first European basic-translational integrated effort in the cardiac regenerative field, with activities that span from the discovery of new targets in animal models to clinical trial design. REANIMA brings together knowledge on species that can regenerate their hearts –fish and amphibians–, animals that cannot regenerate their hearts –adult mammals– and human engineered heart tissues. Strong synergy between partners will allow REANIMA to identify new pathways in regenerative animals and design strategies for their reactivation in non-regenerative animals and human tissue. REANIMA incorporates industrial and academic partners specialised in translational and pre-clinical research, who will develop advanced therapeutic medicinal products and new translational platforms. REANIMA will thus establish a translational pipeline using cross-species gene/protein therapy products with high translational potential, thereby boosting the rapid transition from basic research to the design of clinical trials. We expec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cluster repository project - a basis for evaluating and developing concepts of final repositories for high level radioactive waste' (CROP), addressing dissemination and exploitation.

assistant: **Impact**

For technical/economical optimisation of concepts of future European repositories for rad waste it would be of great help if assessment is made of the experience from the various large-scale underground laboratories for testing techniques and which specifically aims at comparing methods and data obtained from the laboratories for evaluating present concepts and developing improved ones. Several of these underground projects, which deal with disposal in crystalline rock, salt and clay formations, have been supported by the EC. The proposal implies constitution of a forum -a cluster- for the intended evaluation and assessment, focusing on construction, instrumentation and correlation of theoretical models with field data, especially concerning EBS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Upgrade kit for improving treatment efficiency and capacity of new and existing waste water treatment systems' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

In the zeoReactor concept, natural zeolites serve as carrier material for the biology and settlement agent. The ion-exchange properties of the zeolites are the reason for their usage for decontamination of some captions in the water. Using specially modified natural zeolites one can control the ammonia content in the waters. The diffusion velocity of NO3- towards and into the zeolite is greater than the diffusion velocity of 02. It is therefore possible to create an controllable anaerobic environment required for nitrification Because of its large surface area for a settling of the micro organisms significantly higher biomass concentrations compared to traditional activated sludge processes are achieved which directly leads to a reduction of sludge generation. Through these effects, the zeoReactor concept will improve sludge settle ability to enable the plant to operate at a higher solids retention time and thereby improve effluent quality and/or increase plant capacity and enable nitrification to be established arid hence enable a reduction of nutrients discharged from the plant.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sterile neutrino search in tritium beta decay' (SENSE), addressing dissemination and exploitation.

assistant: **Impact**

What is the nature of Dark Matter? What is the origin of the neutrino mass? These are two of the most compelling mysteries, physics is facing today. Despite its tremendous success, the Standard Model of Particle Physics does not provide an answer to these questions. Since the Nobel-prize awarded discovery of the neutrino oscillations, which proofs that neutrinos have a mass, the existence of right-handed partners to the known left-handed neutrinos is a basic assumption. This minimal extension of the Standard Model provides a natural mechanism to generate neutrino masses and can lead to the existence of new types of neutrinos, so-called sterile neutrinos. With a mass in the kilo-electron-volt (keV) regime, sterile neutrinos are a prime dark matter candidate. This dark matter type is especially appealing as it can act as warm dark matter, the existence of which would mitigate problems in our understanding of large-scale structures in the cosmos. The existence of sterile neutrinos with a mass in the eV-volt (eV) regime can resolve puzzling experimental anomalies observed in short-baseline neutrino oscillation experiments. With SENSE, I aim to probe the existence of eV – keV sterile neutrino in a laboratory-based experiment with world-leading sensitivity. A unique way to perform this search is via high-precision beta spectroscopy. The novel idea of SENSE is to develop a beyond-the-state-of-the-art Silicon-Drift-Detector system, which, combined with the large-scale Karlsruhe Tritium Neutrino (Katrin) experiment, will open the window to sterile neutrino signals not accessible elsewhere.My role as analysis coordinator of the Katrin experiment and the expertise in semi-conductor detector technology of my independent Max-Planck-Research group put me in the ideal position to cond
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identification of novel inhibitors to prevent microbial production of pro-diabetic metabolites', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The gut microbiota has been associated with metabolic diseases, such as type 2 diabetes. In my ERC consolidator award we demonstrated that the gut microbiota is altered following bariatric surgery and that the altered microbiota may be directly linked to some of the metabolic improvements observed following surgery. Interestingly, improved metabolism was associated with altered metabolite production capacity from the microbiota and we observed that a metabolite, imidazole propionate, was reduced after surgery. In associated projects we have demonstrated that imidazole propionate is associated with type 2 diabetes in humans and induce insulin resistance in primary hepatocytes and when injected into mice. Imidazole propionate is synthesized by the microbial enzyme UrdA from histidine. This POC will explore the potential of identifying inhibitors of UrdA to reduce production of imidazole propionate and thereby improve insulin sensitivity. If successful we envision a new class of diabetes medication based on the concept of drug the bug.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Recognizing European potential for hosting deep land primary CRM by combining new mineral models and advanced exploration and visualization techniques' (DEXPLORE).

assistant: **Innovation**

DEXPLORE seeks to revolutionize mineral exploration in Europe by developing innovative approaches to counter declining ore deposit discovery rates, focusing on deep-seated deposits critical for the economy's decarbonization. The project emphasizes engaging the general public and stakeholders, combining innovation at various levels, and utilizing cutting-edge tools and technologies. Targeting essential materials across extensive geological terrains, DEXPLORE proposes a holistic innovation package, integrating UAV-assisted in-field mineral detection, advanced Earth Observation methods, and novel deep-land geophysics techniques to reach at least 600 m depth.The initiative outlines the development of updated ore models, improving exploration technologies, and providing a visualization platform. This platform will integrate geological, remote sensing, and geophysical data to enhance access to information about EU potential in critical raw materials, while increasing public awareness. DEXPLORE also aims to strengthen cooperation with strategic partner countries, establishing a robust Advisory Board and fostering collaboration with other EU initiatives for joint activities and result sharing. In summary, DEXPLORE represents a collaborative effort to advance mineral exploration, contribute to sustainable sourcing of critical raw materials, and ensure EU's open strategic autonomy.


**Keywords:** CRM, SRM, deep-land exploration, remote sensing, gravimetry, passive seismic, data visualization, deep-seated deposits, holistic innovation package, integrating UAV-assisted in-field mineral detection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Plasma Enabled and Graphene Allowed Synthesis of Unique nano Structures' (PEGASUS).

assistant: **Concept**

PEGASUS ultimate goal is to create a highly efficient, catalyst/harmful-free novel plasma method along with a proof-of-concept PEGASUS device for a large-scale N-graphene direct synthesis, as well as N-graphene/MnO2/Fe2O3/SnO2 composites and unique vertical N-graphene arrays grown on metal substrates, via breakthrough research on plasma-enabled singular assembly pathways. By doing so, a disruptive and highly competitive alternative to conventional lengthy/multistep routes will emerge,  based on the mastering of plasma exclusive mechanisms to control the amount and localization of energy and matter at atomic scales, spurring a new European manufacturing/processing platform. The envisioned path will prompt and build on ground-breaking developments in the underlying physics, with the resulting processes embodying invaluable economic/social impact potential. PEGASUS framework is uniquely positioned to succeed and raise the Europe competitiveness in the strategic nano synthesis domain via the promotion of plasma methods as a Key Enabling Technology for highly controllable and ""green"" assembly of atom-thick hybrid nanostructures and by replacing long existing materials with new cost-effective, higher performance ones. The synergy between plasma physics and mechanical, electrochemical and hi-tech engineering expertise will be the driving force boosting the innovative approach pursued by this project, spanning from fundamental knowledge to appliance prospects. Internationally recognized scientists will contribute to this interdisciplinary project, triggering the commercialization of novel materials and delivering proof-of-concept PEGASUS and supercapacitor devices. With a science-devoted team lead by a female coordinator, PEGASUS contribution ambitions go beyond the scientifi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Phase map of dynamic, adaptive colloidal crystals far from equilibrium'.

assistant: **Innovation**

We recently reported the first observation of dynamic adaptive colloidal crystals exhibiting characteristics similar to those commonly associated with living organisms: self-replication, self-healing, adaptation, competition, motility. Here, I propose to do the first experiments to clarify precisely how dynamic adaptive behavior arises far from equilibrium and how to control it. The key to both is a fundamental question at the heart of condensed matter, statistical and nonlinear physics: When far from equilibrium, in the presence of fluctuations and faced with multiple steady states with small energy differences, how does a system evolve? Specifically, my objectives are (1) to form crystals with periodic and aperiodic patterns, e.g. 2D Bravais lattices, quasicrystals, using passive identical particles, (2) to quantify their formation energies through the effective temperature of Brownian particles, (3) to identify the conditions for emergence and control of adaptive behavior. Then, I will draw a complete phase map of these dynamic adaptive colloidal crystals using fitness landscapes to characterize each pattern. I will further ask to what extent this control is extendable down to the few-nm scale, where fluctuations are even stronger and if and how these findings change when using nonidentical, in size or shape, but still passive particles. My system comprises quasi-2D-confined pure-polystyrene 500-nm spheres suspended in water. An energy flux to drive the system far from equilibrium and sustain it there is supplied by an ultrafast laser. My method exploits only three physical tenets, nonlinearity, fluctuations and positive/negative feedback mechanisms acting on identical passive particles, yet generates extremely rich emergent dynamics. A full understanding of how such
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The role of protein-tyrosine phosphatases in breast development and cancer' in the context of a Seventh Framework call.

assistant: **Objectives**

Each year 1.1 million new cases of breast cancer will occur among women worldwide and 400,000 women will die from this disease. Although progress has been made in understanding breast tumor biology, most of the relevant molecules and pathways remain undefined. Their delineation is critical to a rational approach to breast cancer therapy. This proposal focuses on the role of the under-explored family of protein-tyrosine phosphatases (PTPs) in the normal and neoplastic breast. Virtually all cell signaling pathways are modulated by reversible protein tyrosine phosphorylation, which is regulated by two classes of enzymes: protein-tyrosine kinases (PTKs) and PTPs. Not surprisingly, tyrosine phosphorylation has an important role in breast development and cancer. Whereas the role of specific PTKs, like the HER2 receptor, in breast cancer is well studied, almost nothing is known about the function of specific PTPs in this disease. Our preliminary data suggest that PTP1B has an important role in breast differentiation and that both PTP1B and SHP2 play positive roles in breast cancer. The two predominant goals of this proposal are: First, to delineate the role of PTP1B and other PTPs in normal breast development and differentiation; second, to address the roles of PTP1B and other PTPs in the maintenance of breast cancer and metastasis and to assess their merits as drug targets. These studies not only use state-of-the-art ex vivo and in vivo models for studying breast pathophysiology, but also cross the boundaries between the developmental and cancer research fields and between basic science and clinical applications. Our research should ultimately lead to the rational design of targeted therapies that will improve the clinical management of patients with breast cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Transcriptional regulation of IL-9-producing CD4 T cells: use in cancer immunotherapy' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Differentiation of naïve CD4 T cells in presence of TGF-beta and IL-4 has led to the identification of a novel IL-9-secreting-population of CD4 T cells, Th9 cells, which are characterized by their potent IL-9 release and their ability to induce proinflammatory responses in vivo. Co-transfer of in vitro differentiated Th9 cells from naïve T cells along with effector cells increase the severity of colitis in mice. Proinflammatory functions of Th9 cells have also been documented in the mouse model of human multiple sclerosis, Experimental Autoimmune Encephalomyelitis (EAE), in asthma and the existence of Th9 cells has been confirmed in humans. Nevertheless, while the transcription factors PU.1 and irf4 have been involved in Th9 cell development in mouse and humans, the mechanisms leading to the generation of these cells remain incompletely understood. In addition, the function of Th9 cells in cancer has never been explored. Our preliminary work suggests that the addition of a proinflammatory factor IL-1 beta during Th9 cell differentiation triggers the high expression of a transcription factor, which might cooperate with irf4 and PU.1 to dramatically enhance Th9 cell effector functions. Generation of Th9 cells in the presence of IL-1 beta also enhances the antitumor properties of Th9 cells in vivo. In this project, we aim to decipher the molecular mechanisms responsible for the effect of IL-1 beta on Th9 cells and identify the factors responsible for the anticancer efficacy of Th9 cells in vivo. Unraveling the mechanisms responsible for the enhanced anticancer efficacy of Th9 cells would not only provide a better characterization of Th9 cell development but would also urge scientists to contemplate their use in cancer immunotherapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Physics of intersubband semiconductor emitters'.

assistant: **Objectives**

Recent years have seen spectacular advances in the performance and functionality of quantum cascade lasers (QCLs) based on intersubband transitions in III-V semiconductor quantum wells. There remain, however, a large number of relatively unexplored areas i n QCL research which offer the potential to raise performance to still higher levels, as well as shedding light on new areas of semiconductor device physics. For example, rapid non-radiative intersubband scattering by LO-phonon emission places fundamental limits on optical gain in current QCL designs, which could potentially be overcome by reducing dimensionality by application of high magnetic fields or by novel structures exploiting semiconductor quantum dots. Similarly, there is considerable need for a f ull understanding of the processes that lead to optical gain in THz QCLs, where the intersubband separation is below the LO phonon energy. The potential for short wavelength operation would be greatly enhanced by improved knowledge of the electronic parame ters of Sb-based heterostructure systems which could lead to the development of intersubband sources and modulators at telecoms wavelengths. Another exciting prospect arises from exploiting the non-linear optical properties of QCL structures to produce a w ide range of operating wavelengths by second harmonic and sum/difference frequency generation. Related studies of structures incorporating photonic crystal waveguides and/or exploiting surface plasmon effects also promise to lead to key advances in QCL fu nctionality. The proposed research training network brings together 9 European leaders in the fields of quantum cascade lasers and non-linear optics to form a coherent body of expertise which is strongly placed to investigate these fundamental areas which prom