RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'UbiqutekGlide: An advanced electrical weed control device to be integrated with existing agricultural equipment, yielding a zero chemical, organic result at a reduced operational cost' under Horizon 2020.

assistant: **Concept**

Reduce herbicide usage. Ubiqutek, a UK-based SME built on over 45 years of research presents ‘Glide’ a cost-effective, safe to use and environmentally friendly electrical agricultural weed control solution to be integrated to existing manufacturer’s agricultural platforms.Benefiting the agricultural market, Glide successfully controls weeds, whilst reducing operational costs and the industries use of herbicides and replacing with an organic process that maintains soil moisture and nutrients and increases crop yield.Having already developed ‘Touch', a horticultural and amenity electronic weed control device that has been well received by the market, we are well placed to adapt our core technology for the agricultural market. During our Phase 1 feasibility study, we have undertaken significant research to prove commercial and technical feasibility including voice of customer and business planning, and are now embarking on our Phase 2 journey. We have an ambitious growth target to achieve revenue of €37.5m pa by 2023, cumulative net profit of €49.6m, and creating direct employment of 14 FTE. We project the ROI to the EC at 4.8 with breakeven at year 4 post-commercialisation.Weeds are controlled largely for food production due to their economic significance: the biotic stresses caused by weeds, insects and diseases cause a 31–42% loss in annual food production globally (€454bn). Herbicides account for over a third of the pesticides used in Europe; without herbicides, it is predicted food prices would increase by 40%With herbicides being legislated against due concerns over their health effects, and given increasing global food requirements, alternative weed control technology is essential in the prevention of unsustainable food inflation. This Horizon 2020 Phase 2 project w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transboundary Drought Risk Management - an application to the Guadiana River Basin' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

TransDRiM is an advanced training and research project focused on transboundary drought management at the river basin scale, in the context of the Water Framework Directive implementation.The proposed methodologies are applied to the Guadiana river basin, the fourth largest within the Iberian Peninsula, where shared watersheds between Portugal and Spain account for over 2/3 of its territory. The Guadiana is of particular interest because of its relative aridity, water scarcity, and high drought risk conditions.A political agreement (the Albufeira Convention) regulates cooperation and conflicts on water issues between the two countries, but an exception regime is applied under drought conditions – thus, when most needed, common management is reduced to a minimum. Furthermore, water planning remains strictly at the national level, and public participation continues to be insignificant, contrary to the WFD guidelines.TransDRiM seeks to minimize environmental, social and economic impacts of cross-border drought events, reduce potential conflicts on water uses and availability between both riparian countries, and provide a methodological framework for transboundary drought risk management across EU river basins.In order to reach these goals, the following specific research objectives will be pursued: Identify the potential and constraints for a transboundary policy of drought risk management; Assess the compatibility of the two national planning structures; Provide technical solutions to establish a transboundary and operational drought management framework; Assess the feasibility of transboundary drought response measures proposed, based on their economic, political and social criteria.TransDRiM will address these tasks based on a territorial and interdisciplinary approach,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Harnessing experimental evolution of rhizobia for an integrative view of endosymbiosis' (HARNESS) under Horizon 2020.

assistant: **Objectives**

Microbiota shape growth and survival of eukaryotes through countless symbiotic associations. A prominent example for agriculture is the mutualistic nitrogen-fixing symbiosis between legume plants and rhizobial bacteria. Understanding the evolution and functioning of these symbioses offers promises to optimise their beneficial use in agro-ecosystems and, potentially, to extend it to non-legume plants. An ambitious project initiated several years ago in the host team aims at recapulating the evolution of new nitrogen-fixing bacteria from a pathogenic ancestor. A symbiotic plasmid was artificially transferred into the plant pathogen Ralstonia solancearum and the resulting chimera was selected for improved in planta symbiotic performance by experimental evolution. This experiment offers a unique opportunity to witness the ‘real-time’ adaptation of chimeric bacteria to their new host plant. In this proposal, I will leverage the biological material generated during this experiment to progress towards an integrative understanding of the evolutionary events underpinning the transition to symbiosis. In particular, I will focus on the acquisition of intracellular uptake and accommodation of bacteria by plant cells, a defining and poorly understood aspect of these symbiotic associations. First, I will use whole-population sequencing to track allelic frequencies in evolving populations and identify mutations improving bacterial intracellular fitness. Functional genetics analyses will then uncover the bacterial functions that are required for endosymbiotic life. Finally, plant transcriptional responses to bacteria showing different infectious abilities will be analysed by RNA-sequencing. Altogether, this work will use a combination of approaches (experimental evolution, genetics and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'GENERATION OF NEW ANTI-RABIES ANTIBODIES FOR POST EXPOSURE PROPHYLAXIS AND PRODUCTION IN PLANTS.' (PLANTIRABIES), addressing dissemination and exploitation.

assistant: **Impact**

Infection by rabies virus causes about 40,000-70,000 deaths per year worldwide. More than 99% of all human deaths occur in Africa, Asia and South America, most commonly involving children aged under 15 years. The recommended therapeuthic procedure for peop le suspected to be infected with this virus includes the immediate administration of both vaccine and rabies specific immunoglobulins (RIG). Prophylaxis in the form of immunoglobulins includes equine anti-rabies immunoglobulins (ERIG) or human anti-rabies Ig (HRIG), however these reagents are expensive, and in short supply especially in developing countries. One solution that is being explored is to generate a cocktail of rabies neutralising monoclonal antibodies to replace ERIG. If it were possible to gene rate enough recombinant antibodies cheaply, then this would be of enormous benefit in rabies affected countries, particularly in SE Asia and Africa In this proposal we aim to select new and cross- neutralising antibodies against lyssavirus strains using re combinant antibody phage-display technology. Two single chain Fv antibody phage display libraries will be used, a human naïve library and a synthetic murine scFv library derived from a stable protein scaffold. The selected scFvs will be tested for in vitro virus neutralization assays and up to two antibodies will be chosen for engineering back into the heavy and light chains of a human Ig, generating chimeric anti rabies Mabs. The engineered antibodies will initially be introduced into tobacco plants to as sess plant expression in plants. Ultimately, the aim is to use transgenic maize expression, but this is beyond the scope of the current application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sensor fused intelligent monitoring system for machining' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The trend of modern flexible manufacturing systems towards a structure consisting of conglomerates of small, intelligent and flexible units supporting fast monitoring and control loops requires new solutions to guarantee reliable processes performed by these systems. It especially increases the demand for achieving and monitoring quality and performance by solutions integrated into intelligent systems like machine tools. Since disturbances in such flexible manufacturing systems cannot be eliminated completely, it is attempted to detect them and to deal with them with the help of monitoring systems. Sufficient increase in productivity and quality is only possible if the deficits of current monitoring systems, e.g. insufficient reliability, high degree of necessary operator efforts and lack of integration into the control of machine tools, can be overcome. The objective of SIMON is to develop a flexible and reliable process monitoring and control system for a wide range of applications in manufacturing, which:- integrates all available sources of information, e.g. external sensors, data inherent to the NC and process models;- is applicable to different machining processes and largely independent of the type of NC, and- is suited for the use as an integrated part of a flexible manufacturing system and can be integrated into its control and quality management systemThat way, the system- reliably detects process disturbances, e.g. collision, tool breakage and tool wear,- allows for automatically initiated appropriate response to process disturbances, and- will ensure reliable manufacturing of high quality products in flexible manufacturing systems starting with the first workplaceFor the SIMON project the milling process has been chosen for application, being an example of d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Unconventional Principles of ThermoElectric Generation' (UPTEG), addressing dissemination and exploitation.

assistant: **Impact**

The performance of thermoelectric generation has long since been limited by the fact that it depends on hardly tunable intrinsic materials properties. At the heart of this problem lies a trade-off between sufficient Seebeck coefficient, good electrical properties and suitably low thermal conductivity. The two last being closely related by the ambivalent role of electrons in the conduction of both electrical and thermal currents. Current research focuses on materials composition and structural properties in order to improve this trade-off also known as the figure of merit (zT). Recently, evidences aroused that nanoscale structuration (nanowires, quantum dots, thin-films) can improve zT by means of electron and/or phonon confinement. The aim of this project is to tackle the intrinsic reasons for this low efficiency and bring TE conversion to efficiencies above 10% by exploring two unconventional and complementary approaches:Phononic Engineering Conversion consists of modulating thermal properties by means of a periodic, precisely designed, arrangement of inclusions on a length scale that compares to phonon means free path. This process is unlocked by state of the art lithography techniques. In its principles, phononic engineering offers an opportunity to tailor the phonon density of states as well as to artificially introduce thermal anisotropy in a semiconductor membrane. Suitable converter architecture is proposed that takes advantage of conductivity reduction and anisotropy to guide and converter heat flow. This approach is fully compatible with standard silicon technologies and is potentially applicable to conformable converters.The Micro Thermionic Conversion relies on low work function materials and micron scale vacuum gaps to collect a thermally activated current a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multifunctional Personalized Self-Assembled Biomaterials for Bone Regeneration' to be submitted under Horizon 2020.

assistant: **Abstract**

Bone regeneration is a critical challenge in the treatment of fractures, bone loss due to tumor resection, and alveolar bone deficiencies. Currently, approximately 2.2 million bone graft procedures are performed annually worldwide. Despite significant progress in bone tissue engineering, there is an unmet need for patient-specific long-lasting bone restoration to reproduce the unique physical, chemical, and biological properties of hierarchically structured bone in a personalized manner. While bones can often naturally self-heal, critical-size bone defects lead to a failed repair process. Expanding on the current understanding of bone regeneration, I will integrate the biomechanical and immunological triggers of the healing process into an artificial bio-mimicking scaffold to specifically target critical defects. Thus, I aim to develop a conceptually new approach of personalized layered 3D-printed supramolecular scaffolds.I intend to use a bottom-up multi-component co-assembly to produce tailored, layer-by-layer printed, extracellular-matrix-mimicking scaffolds that not only fit the defect shape, but also mimic the bone composition around the defect. For this purpose, I will significantly expand the repertoire of our proprietary peptide-based hydrogel technology by chemical modifications that allow interaction with bone minerals, slow release of growth factors, and activation of the immune system to trigger healing. I will combine computerized tomography scans and computer-assisted manufacturing to design personalized scaffolds that can be studied in an alveolar bone model, and be customized to accommodate bone type, structure, gender, age, and systemic diseases. PersonalBone aims to develop customized supramolecular scaffolds that will promote personalized therapy for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Contact Mechanics of Soft and Complex Biological Tissues'.

assistant: **Innovation**

In the last decade, a number of medical and bio-engineering challenges, requiring a deep understanding of the phenomena occurring at biological interfaces, have intensified scientific interest in the field of biological contact mechanics. BIOCONTACT will develop an innovative methodology to tackle bio-lubricated contacts involving soft tissues in the presence of complex fluids, enhancing the understanding of these interactions, by pursuing new models and numerical methodologies, specifically suited for this class of problem. This approach is key to provide long-term societal benefits by solving long-standing issues including the prevention of hospital bedsores, the mechanical compatibility of prosthetic implants or contact lens, and the optimization of surgical procedures and tools. In particular, my vision is to first build a mechanical model for biological soft tissues that specifically uses constitutive laws for multi-layered linear viscoelastic materials. This model will be then implemented in a newly developed contact mechanics solver, based on improved Boundary Element Method schemes that I have recently proposed, and that will be able to capture specific chemo-mechanical local responses adopting mean potentials that rely on atomistic and molecular descriptions of the interface. In the framework of inverse analysis, the material properties of individual layers will be tuned to best replicate the experimental behavior captured using an innovative procedure. This relies on a new scale separation methodology and is able to probe different zones and layers within the tissue. Finally, in order to provide a complete and widely applicable tool, solid-liquid interaction will be addressed by coupling the contact model with a lubrication model, based on non-Newtonian Reynol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Probing r-process nucleosynthesis through its electromagnetic signatures' (KILONOVA).

assistant: **Innovation**

The lightest chemical elements –Hydrogen and Helium– were created about a minute after the Big Bang. Elements up to Iron are forged by fusion reactions in stars. Heavy elements between Iron and Uranium are produced by a sequence of neutron captures and beta-decays known as rapid neutron capture or r process. The freshly synthesized r-process elements undergo radioactive decay through various channels depositing energy in the ejecta that powers an optical/infrared transient called “kilonova” whose basic properties like luminosity and its dependence on ejecta mass, velocity, radioactive energy input, and atomic opacities I contributed to determine for the first time. Our predictions have been dramatically confirmed by the observation of a kilonova electromagnetic transient associated with the gravitational wave signal GW170817 providing the first direct indication that r-process elements are produced in neutron-star mergers. Additional events are expected to be detected in the following years, representing a complete change of paradigm in r-process research as for the first time we will be confronted with direct observational data. To fully exploit such opportunity it is fundamental to combine an improved description of exotic neutron-rich nuclei involved in the r-process with sophisticated astrophysical simulations to provide accurate prediction of r-process nucleosynthesis yields and their electromagnetic signals to be confronted with observational data. Based on my broad knowledge and expertise in all the relevant areas, and the unique experimental capabilities of the GSI/FAIR facility, I am in prime position to advance our understanding of r-process nucleosynthesis and determine the contribution of mergers to the chemical enrichment of the galaxy in heavy elements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A toxin-free, food-safe, autonomous mobile misting disinfection system that eradicates pathogens within 5 minutes and gives residual protection for 24 hours reducing the need for water and antibiotics', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Residual Barrier Technology Ltd. is an SME set up with the aim of developing disruptive, green sanitation products whiledelivering higher performance than state of the art solutions and thus achieve impact globally.Disinfectants are relied on as the last line of defense against ever-evolving bacteria and viruses – but due to currentchemistry they come with inherent disadvantages including, toxic/mutagenic ingredient use and offers no residual protection.Methods application such as spraying, fogging and fumigation are time and labour intensive and provide inconsistent andincomplete coverage.We have developed VIRIDIS a patent pending non-toxic, non-mutagenic platform disinfectant that is a breakthrough in thefight to effectively eradicate bacterial pathogens, spoilage organisms, and viruses. However, VIRIDIS MIST does not stopthere – once deposited on a surface the advanced micelles holding the active ingredients crystallise to create a protectiveresidual barrier that has been independently proven to continue to kill bacteria for days even when dry - preventing themfrom rebuilding or mutating to form a resistance.We currently work with clients in the food processing and agriculture market to design and fit bespoke large scale residualmisting systems for their facilities operating on a service charge model. However, there is a considerable expense and timeinvolved in installing the network of fixed pipes and nozzles at their sites – making it cost prohibitive in small to medium sitesand impossible to implement in haulage and shipping contexts. VIRIDIS MIST will service this much larger market micromediumscale market through the use of autonomous mobile apparatus. We are requesting funding for the development andproduction of 24 demonstrator application (8 x 3 different siz