RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A new brain-dedicated Positron Emission Tomography (PET) system to identify β-amyloid biomarker for the early diagnosis of Alzheimer’s disease and other causes of cognitive decline' in the context of a Horizon 2020 call.

assistant: **Objectives**

ONCOVISION is a Spanish SME specialised in design, development, production and commercialisation of organ-dedicated PET systems. Our company submits the present business innovation project with the overall objectives of (1) marketing an innovative brain-dedicated PET system to early diagnosis of Alzheimer’s disease (AD) and other causes of cognitive decline based on the detection of amyloid-β biomarker in the brain using three 18F-labelled tracers recently approved by FDA and EMEA (Florbetapir, Florbetaben, and Flutemetamol) for their clinical use, and (2) validating the clinical performance of this new diagnostic medical device. This new brain-dedicated PET system, targeted to Mental Disorder Units and Nuclear Medicine Units of hospitals in Europe, USA and Japan, is unique in the market and offers several advantages compared to the whole-body PET systems, such as higher resolution, three times higher sensibility, a competitive price (up to three times lower), need of smaller hospital facilities, and lower radiotracer dose to the patient that leads to a lesser cost to the healthcare system. Due to these improved characteristics, the new brain-dedicated PET system will allow an early detection of AD and other causes of cognitive decline and to use this business opportunity to ensure profitability and growth of ONCOVISION. A Phase 1 project was previously funded and implemented (Call: H2020-SMEINST-1-2014; Cut-off date: 18th June, 2014; Topic: PHC-12-2014/2015 Clinical research for the validation of biomarkers and/or diagnostic medical devices; Proposal number: 651145). The feasibility study prepared in Phase 1 has verified the technological as well as economic viability of the product and its clinical validation. During Phase 2 the validation of clinical performance of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Development of a Multispectral, Versatile Film Scanner'.

assistant: **Concept**

Film archives contain large and diverse collections of historical films. In order to exhibit and exploit these collectionscommercially, archives need to digitize their holdings. With more than 400 Mio. € per year globally and growth rates of 8 %annually, the digitization of analog film material is an exponentially growing market.However, as a study by the research team has shown, there is no professional high-end film scanner on the market that isable to digitize the whole range of these films.The PoC VeCoScan tackles this lack of technical solutions by developing and testing a multi-spectral and versatile core filmscanner unit. This versatile design will allow the film scanner to adapt the spectral distribution and the directionalarrangement of its illumination system, based on colorimetric measurements of film stocks executed by the research team.The higher image quality of the raw scans will achieve better results in terms of both the accuracy with the original colorsand the potential to digitally reconstruct faded colors that concern an estimated 90% of chromogenic film stocks up to 1980.The most important bottleneck in digitization workflows is the optical set-up of the scanners. The second bottleneck is alack of knowledge of historical films on the part of most service providers. The PoC will address both of these currentdrawbacks: by improving the scanner, and by delivering a comprehensive package that includes information about the filmstocks’ physical properties and models for color reconstruction, in line with high scientific standards. As a result, scanningand post-processing times will be greatly reduced and workflows will become much more cost-efficient. Furthermore, anaccurate digital rendition of analog films is crucial for the long-term sustainability of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Assembling data and knowledge at the point of care to improve medical decision making and prevent errors' to be submitted under Sixth Framework.

assistant: **Abstract**

A large number of patients are harmed by Wrong decisions and by medical errors. Data and knowledge needed to reach a correct decision and prevent errors are many times stored in the electronic universe but not available for use. Means to prevent errors are easy to envision in an electronic environment, but are seldom employed. Our main objective is to bring together at the point of care all information available on patients in the electronic accessible universe, together With relevant knowledge and evidence; and make use of this data and knowledge in computerised decision support modules, to improve medical decision-making and prevent medical errors.Thus we intend to implement:(1) A system that will prepare and deliver to the point of care a fully integrated patient-object including all data available on the patient in the electronic universe.(2) A generic mechanism for intelligent decision support that will be triggered by patient profiles based mainly on causal probabilistic models and use it to construct modules that will address main problems in medical decision-making and medical error prevention.(3) A generic application for harvesting best evidence and knowledge available from high-quality peer-reviewed resources and present it to the clinician in a convenient and uniform format, at the point of care(4) Innovational computing techniques (mainly distributed computing) and advanced security solutions, in order to afford speed, flexibility and safety to the application, and remove obstacles to sharing of information.(5) An innovative interface that will allow the platform to interface seamlessly with the clinician at the point of care.(6) integration of all components and validation in 4 medical centres in 4 countries, to demonstrate its potential to reduce errors a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Materials Engineering of Integrated Hybrid Spectral Converters for Next Generation Luminescent Solar Devices' (SPECTRACON) targeting Horizon 2020.

assistant: **Abstract**

Solar energy conversion will play a key role in our transition to a carbon-neutral society. However, single junction photovoltaic (PV) cells fail to achieve their theoretical efficiency due to an inability to harness all wavelengths of the solar spectrum. Spectral losses may be overcome through the addition of a spectral converter coating to the surface of a finished PV cell, which, through a photoluminescence process, converts solar photons into wavelengths suitable for use. Nonetheless, spectral converters currently fail to deliver their promise to significantly boost PV cell performance due to the difficulties of translating luminescent molecules (lumophores) from solution into efficient solid-state materials.By considering the lumophore-host material as an integrated unit, rather than discrete components, in SPECTRACON, I take a radically new approach to the design of spectral converters. Organic-inorganic hybrid polymer hosts incorporating covalently-grafted lumophores will be rationally engineered to deliver spectral converters with the tailored optical, structural, viscoelastic and mechanical properties needed for high performance solid-state conversion, which has so far been unattainable. Using cheap materials and a solution-based process suitable for scalable manufacturing, these spectral converters will be integrated with PV cells to realise next generation luminescent solar devices which display record levels of efficiency and reduced costs.A scientific breakthrough that demonstrates efficient solar spectral conversion in the solid-state would enable immediate deployment of luminescent solar devices to the commercial market, thus accelerating progress to an all-renewables society and delivering unprecedented impact on the quality of life of future generations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Exploring the Eastern and the Western Debate: the Case of Mathematics Teachers’ Professional Knowledge and Students’ Achievement - A Comparative Study between Germany and China' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

International comparative studies (e.g., TIMSS or PISA) found that East Asian students outperformed their Western counterparts, which raised the interest in comparative studies between ‘‘Eastern’’ and ‘‘Western’’ cultures significantly. Educational policies in many countries have been revised referring to the results. However, the question how to explain students’ achievement differences referring to the professional competence of the teachers and the teaching-and-learning processes provided by them has not been in the focus of studies. In view of this, the proposed project aims to investigate differences and similarities of mathematics teachers’ professional competence and the relation to students’ learning outcomes in Eastern and Western cultures with Germany being the Western protagonist and China serving as protagonist for Eastern cultures. Approximately 300 mathematics teachers and their students (about 8,500) in China and in Germany will participate in the study. Mathematics teachers’ professional competence will be evaluated using adapted instruments in a previous international comparative project on teachers’ knowledge (TEDS-M) and a follow-up study (TEDS-FU) through the means of web-based and video-based testing. Students’ mathematics achievements and their achievement progress over one year will be evaluated using regular achievement tests at national level in China and at Federal level in Germany. Similarities and differences of Chinese and German mathematics teachers’ professional competence and its connections to students’ mathematics achievements will be analyzed. Social and cultural influences will be further explored for a mutual understanding of the differences and similarities. Based on these results recommendations for the change of German and Chinese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Feeling Polarity: Integrating intracellular mechanics and forces for a biophysical understanding of epithelial polarity' in the context of a Horizon 2020 call.

assistant: **Objectives**

Epithelial polarity is one of the most fundamental types of cellular organization, and correct cellular polarization is vital for all epithelial tissue. Failure to establish polarity leads to severe phenotypes, from catastrophic developmental deficiencies to life-threatening diseases such as cancer. Despite knowing much about the signalling and trafficking machinery vital for polarity, we lack quantitative knowledge about the intracellular mechanical processes which organize and stabilize epithelial polarity. This presents a critical knowledge gap, as any elaborated understanding of intracellular organization needs to include the forces and viscoelastic mechanical properties that position organelles and proteins. As such, the main aim of POLARIZEME is to determine the intracellular mechanical processes relevant for epithelial polarization, thus providing a mechanical understanding of polarity. We will combine advanced optical tweezers technology with cutting-edge molecular biology tools to rigorously test new intracellular transport concepts such as the active, diffusion-like forces that can position organelles or the recently introduced cortical actin flows that can drag polarity-defining proteins around the cell. Thus we propose (i) to quantify active forces and intracellular mechanics and their relation to organelle positioning, (ii) to quantify polarized cortical and cytoplasmic flows, and (iii) to measure the forces and mechanical obstacles relevant for direct vesicle trafficking. These quantitative biophysics experiments will be supported by mathematical modelling and the development of two new instruments which (a) allow for automated intracellular mechanics measurements over extended time periods and (b) combine multi-view light-sheet microscopy with optical twe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Advanced design rules for optimMAl Dynamic properties of Additive Manufacturing products' in the context of a Horizon 2020 call.

assistant: **Objectives**

Additive manufacturing (AM) belongs to key enabling technologies where Europe has the leading research role. The AM technologies put considerably fewer limits on shape of the manufactured objects than conventional technologies, and offer unparalleled freedom to industrial and mechanical designers. Since the AM technologies are insensitive to production scale, they put in focus knowledge and creativity of designers instead of low prices of mass production, paving the way to development of new business models. The AM technologies, therefore, represent a technology platform that may best serve Europe in its intent to develop knowledge-based economy, driven by innovation.However, the industrial deployment of AM technologies is hindered by a gap that exists between the excellent research and its exploitation in industry. The research knowledge about the AM technologies is published in scientific journals and in conference proceedings, in form suitable for researchers. On the other hand, industrial and mechanical designers use sets of design rules, which represent condensed and comprehensive form of the research findings that are easy to follow. The lack of sets of design rules for AM technologies is one of important reasons why engineers often prefer conventional technologies to AM.The proposed project intends to use the research capacities and partnerships developed in previous EU funded projects to carry out systematic studies of dynamic mechanical properties (fatigue, fracture mechanics and impact resistance) of products manufactured by AM with the goal to establish the proper rule sets for design of products. Since the aim of the project is to “translate” the research findings into engineering rules, the consortium consists of two universities and three SMEs that use AM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Stock effects on recruitment relationships (An operational model of the effects of stock structure and spatio-temporal factors on recruitment).' (STEREO) targeting Fourth Framework.

assistant: **Abstract**

The overall objective of the project is to improve the methodology for determining limit reference points for the biomass of exploited fish stocks.Limit reference points set boundaries which are intended to constrain harvesting within safe biological limits, and are integral components of the decision making process in fisheries management. In most cases limits are currently estimated from historical time series data on spawing biomass and recruitment. However, the underlying stock-recruitment relationship is often purely defined by such data and hence there is considerable uncertainty around many reference limits. This project will produce an operational scheme for refining these data by integrating biological, spatial and temporal information on the stock, with the aim of reducing the uncertainty associated with biological limits. The methodology will be developed for cod and haddock stocks around Iceland, Norway and in the North Sea as case studies.The project targets one of the major topics currently being discussed in management procedures related to the precautionary approach. The project follows a very promising new approach, focusing in the incorporation of maternal, spatial and temporal effects on the effective reproductive output of the spawning stock, as well as the survival and growth of larvae.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Defining mechanisms of cellular stress responses driven by heterotypic ubiquitin chains' under Horizon 2020.

assistant: **Concept**

Posttranslational modification of proteins with monoubiquitin or different polyubiquitin chains alter protein function to signal distinct responses in cells and thereby regulate every aspect of eukaryotic biology. Recently, ubiquitin has also been reported to form branched heterotypic chains. The central premise of this proposal is that branched ubiquitin chains adopt unique conformations and convey distinct intracellular signals essential for maintaining cellular homeostasis. We posit that branching of homotypic ubiquitin chains or de novo formation of branched structures occurs in response to specific cues and they serve as priority signals to mediate prompt cellular responses. The complex nature of branched heterotypic ubiquitin, the lack of tools to specifically and efficiently probe different branched ubiquitin structures and the relatively low abundance of these chains in a cell make it challenging to study them. In this proposal, I will describe an ambitious approach to define how branched ubiquitin serve as unique signals to elicit cellular stress responses. To attain these goals, we will pioneer the development of novel designer tools and methods, which we will combine with quantitative proteomics, single cell analyses, biochemistry and structural biology. We will elucidate the molecular players involved in the assembly, decoding and regulation of branched ubiquitin. We will develop approaches to monitor branched ubiquitin formation in cells to identify stress conditions that trigger formation of branched ubiquitin chains. We will functionally characterize how distinct branched heterotypic ubiquitin signals are formed in response to stress and serve as priority signals to trigger stress-response pathways. Our work will shed light on fundamental principles of in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Worm control in organic production systems for small ruminants in europe: towards the implementation of non-chemical, sustainable approaches.'.

assistant: **Concept**

Nematode parasitic infections constitute a serious health and welfare problem of sheep and goats in organic farming systems. Research will focus on the following non-chemical strategies for the control of these infections:- Use of bioactive plants, particularly forages with a high content of condensed tannins.- Biological control with the nematode-destroying fungus Duddingtonia flagrant.- Grazing management procedures, particularly evasive grazing based on new knowledge of the survival of nematode stages on pasture. Recommendations for the use of these strategies alone or in combination in sheep and goats will be developed and disseminated. Although primarily aimed for organic farming, guidelines will be equally applicable in conventional farms as a new, sustainable approach to parasite control.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of Biomaterial-based Delivery Systems for Parkinson’s disease - an Integrated Pan-European Approach' to be submitted under Horizon 2020.

assistant: **Abstract**

BrainMatTrain focuses on a comprehensive understanding of Parkinson’s disease (PD), from basics to translation, fully supported by 8 full partners partner organisation (4 research institutions, 2 hospitals, 2 SMEs) and one partner organisation (SME specialist in device design). This ETN will educate and train 15 Earlty Stage Researchers (ESRs) in functioanlised biomaterials, materials science, functionlisation strategies, molecular biology,  stem cell biology, in vitro model systems, in vivo neuroimaging, animal models and prototype design. Recruited ESRs will receive compulsory discipline-specific, generic and complementary transferable skills training. BrainMatTrain will develop multi-modal collagen reservoir scaffolds incorporating moieties targetitng the neuroinflammatoiry and neuroprotective phases of the underlying pathology of Parkinson’s disease. The researchers will undertake cross-disciplinary and intersectorial research projects, which when married together will deliver a novel, biomaterial-based, therapeutic device for the treatment of Parkinson’s disease. The research training programme is designed to ensure high-calibre graduates, best placed to secure employment in the private or public sector. Fellows will experience both private and public sector research and development environments through a considered secondment plan.