RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New Targets for Antifungal Therapy - Molecular Biology of Dimorphism in the Human Pathogen Candida Albicans', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

To search systematically for morphogenic genes (gene disruption by transposon insertion, differential mRNA display) To analyse the early events in morphogenesis involved in the regulation of the cell cycle and the transcription regulation To analyse the late events, e.g. the establishment of cell polarity by the actin cytoskeleton, vesicle transport and regulation of cell wall synthesis Candida albicans is the most common fungal pathogen of humans. It is capable of a dimorphic transition between two growth forms. The hyphal form appears well adapted to penetrate epithelia, and hence this growth form probably plays an important role in the progression from superficial to deep-seated infections. However, the molecular mechanisms by which hyphal growth is controlled in C. albicans remain obscure. This is partly due to the genetic intransigence of C. albicans which is diploid and asexual. However, the recent development of new tools for the molecualr dissection of this yeast is now allowing rapid progress which will bear fruit in the near future. Yarrowia lipolytica also provides a valuable model to study the regulation of fungal dimorphism. Like C. albicans it is dimorphic, but it is an apathogenic yeast which has been under genetic and molecular investigation for several years. Involvement of Y. lipolytica will definitely increase the scientific value of the project, because like C. albicans, its hyphae are different structurally to the pseudohyphae of S. cerevisiae. Conclusions made from results obtained on S. cerevisiae are not always directly applicable to C. albicans. In this context the subprojects will study one specific aspect of morphogenesis, i.e. the regulatory hierarchy that controls the switch from a yeast cell to a hypha. The individual groups will collaborat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advanced System for Eco, Energy and Cost Efficient, Comfortable and Secure Smart Homes' (HIQ-Home) targeting Horizon 2020.

assistant: **Abstract**

Current smart homes are not as “smart” and user-friendly as promoted. They enable household monitoring and appliance control with several new HW and SW solutions and extensive manuals, but do not automatically adapt to the user’s living habits. Moreover, studies showed that smart home schedules set by the users are widely inefficient thus contributing to excessive energy usage. Initial tests show that up to 33% of energy saving can be achieved with our innovative approach.The presented product tries to breach the gap between the users and a truly smart home by introducing an on-demand cloud service that implements multi-criteria optimization and dynamic user profiling methods in order to optimize performance in any smart building and in particular connected into a smart city. Moreover, the user can only qualitatively set a couple of parameters and then select one of the control strategies proposed by the system, dealing with balance of energy preserving, comfort and security. Optimization methods achieve even higher energy savings with alternative energy sources, e.g., photovoltaic energy. The technological feasibility of the project was already verified on a small house prototype.The market potential for the presented service is extremely high, with the revenue growth estimated to reach $51.77 billion by 2020, at an estimated CAGR of 29.5%. Several key players like Google are entering the market indicating another global dominance. We are in contact with several global  market providers to speed-up the commercialization of our product. During the feasibility study we will mainly focus on market analysis, user needs, the range of provided services and functionalities, and the pricing mechanisms. Additional technology verification for a large scale application will be co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Torque Vectoring Platform for Next Generation of Electric Driven Vehicles' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The main objective of the TVP-eNext project is the development of a modular and scalable component solution for battery electric vehicles (BEV) and serial hybrid electric vehicles (HEV), which reduces both the cost and the complexity and increases the efficiency of the new generation electric drivetrains and simplifies the effective mechanical, thermal and electrical integration into the vehicle. The TVP-eNext project will deliver a unique Torque Vectoring hardware-software Platform (TVP) for torque vectoring system for vehicles with electric drivetrains with one electric motor per wheel. This type of new generation components enables software based torque distribution to individual wheels. It simplifies the implementation of the vehicle sub-systems, like Anti-lock Braking System, Traction Control System and Electronic Stability Program and enhances reliability, safety, stability and robustness of electric driven vehicles. Our TVP is compatible with any kind of BEV or serial HEV, such as with urban cars, common cars, sport cars, working vehicles, All-Terrain-Vehicles, trucks, buses, urban commercial vehicles and Heavy Duty Vehicles. We are addressing the trends and needs of the electric vehicle market. Considering the pitfalls of the existing solutions available to the commercial sector, we plan to address the market challenges of automotive component manufacturers, seeking to complement their product portfolio, as well as of the automotive manufacturers, where concrete interest in our solution already exists.  The purpose of the SME Phase 1 TVP-eNext project is to outline the full scope of further development potential of our innovative solution, involving the technical and business viability issues, also regarding the analysis of the associated risks and the exploitat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of the p38 MAPK pathway in the liver: a genetic approach' (EMBL-TL) targeting Sixth Framework.

assistant: **Abstract**

Cytokine activated inflammatory signalling pathways have been implicated as important mediators of liver injury and are thought to be involved in the development of hepatocellular carcinoma. The p38 mitogen-activated protein kinase (MAPK) pathway is a key mediator of cytokine-induced signalling, but its role in liver injury remains elusive. In this project I propose to investigate in vivo the role of p38alpha (p38a) in experimental models of liver disease, by taking advantage of genetically modified mice with a liver-cell specific deletion of the p38a gene generated by using the Cre/loxP technology. I will analyse the function of p38a in three different models of liver disease: chemically induced hepatocellular carcinoma, liver regeneration after hepatectomy and ischemia-reperfusion injury.For these experiments I will use well-established experimental protocols and microsurgical techniques that I have already learned during my previous work. In the second part of my project, I propose to generate a new knock -in mouse line that will facilitate the conditional in vivo replacement of p38a with a mutated kinase-dead version of this protein. By generating this mouse line it will be possible to conditionally ablate the activity of p38a rather than deleting the whole protein, thus avoiding unwanted compensation from the other members of the p38a family. Using this approach it will be possible to resemble the effect of a pharmacological inhibition of p38a, much closer than a knockout of the gene can do.By combining advanced technology in mouse genetics with clinically relevant experimental models of liver injury, these experiments will clarify the function of p38 signalling in liver disease and will contribute to the better understanding of the molecular mechanisms involved in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ocean Limiting Nutrients – Examination from Space' (OceanLiNES) targeting Horizon 2020.

assistant: **Abstract**

Marine phytoplankton are the conduit for the flow of energy and carbon into the ocean; consequently they are responsible for the distribution of global fish stocks and regulate climate. Fundamental insights into the productivity of marine phytoplankton can be gained from determining which nutrients are limiting phytoplankton and how these are being altered due to climate change. The approach to investigate nutrient limitation of phytoplankton thus far has been to conduct observations and experiments at sea; however, these activities require substantial investment of resources (ship-time and personnel) and only reveal a snapshot in space and time. A method for making synoptic, low-cost observations using remote sensing would be invaluable. Phytoplankton abundance can be monitored from space using satellite images of ocean colour and a major breakthrough would be to extract a diagnostic signal of phytoplankton stress to monitor patterns of nutrient limitation. Phytoplankton fluorescence signals detected by sensors on satellites carry significant potential for doing this, yet fundamental uncertainties underlying what exactly regulates the signal firstly need to be resolved. Here we propose to perform experiments in targeted regions of the global ocean to address these uncertainties and develop an algorithm to reveal global nutrient limitation patterns of marine phytoplankton using satellite-detected fluorescence. The overarching objectives of the project are to (i) conclusively assess the influence of nutrient limitation other environmental variables on phytoplankton fluorescence characteristics; (ii) implement a correction of the phytoplankton fluorescence signal detected by satellites to reveal global nutrient limitation patterns; and (iii) apply this new understanding o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A highly integrated and sensitive PORous SIlicon based lab on a chip for multiple quantitaTIVE monitoring of Food allergies at point of care' (Positive) targeting Seventh Framework.

assistant: **Abstract**

By integrating and interfacing multiple core technologies and related materials from fluidics and photonics technology to porous silicon (porSi) and polymers, Positive will target the implementation of a microsystem tailored to a specific application with a key societal and economic need. The very high surface to volume ratio of porSi permits very high surface densities of bound antibody-antigen complexes in a reduced volume that through a novel optical interaction leads to scores of sensing areas on a 1cm2 chip with detection-limits down to ~0.1 pg/mm2, significantly beyond state of the art for highly integrated label free sensors at point of care. This offers the further advantageous possibility of assaying several parameters simultaneously (multi-assay) leading to further increases in the reliability and reductions in the measurement uncertainty of a diagnostic over single-parameter assays. The novel Lab-on-Chip technology has the potential to be fast and easy to use, making routine screening or monitoring with immunoassays more cost-effective.The ultimate goal of Positive will be to demonstrate a safe and rapid low cost diagnostic test for food allergies at point of care such as in a GP's office or hospital. A quantitative determination of allergy sensitization is expected within ~15' of adding no more than 100µl of blood. A final prototype consisting of a packaged biochip and reader will be used on clinical samples in order to determine sensitization to allergens such as that for hen's eggs, cow's milk, peanuts, wheat, treenuts, fish, sesame, and shrimp ingestion.The two industrial partners with their international market strategies and a clinical specialist for food allergies in children as an end-user will enable us to target the whole value chain from research t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Evolution on an island continent: feeding ecology of Pleistocene sloths' (FEPS) targeting Horizon 2020.

assistant: **Abstract**

South America (SA) contains Earth’s highest mammalian species richness, but this richness was exponentially higher just 10k years ago, prior to the last ice age extinction that eliminated more than 80% of mammals in the continent. With only two living genera restricted to tree-dwelling in rainforests, sloths once were a dominant group within SA mammalian ecosystems. Fossil sloths are generally considered plant eaters, like their modern relatives, but their extremely high diversity (in terms of body mass [4-4000 kg], geographical distribution [Patagonia to Alaska], habitats [coast, mountains, rainforest] and inferred locomotion [terrestrial, fossorial, arboreal, semiaquatic]) suggests that these were ecologically more versatile than traditionally thought. The primary goal of this project is to determine the dietary composition of fossil sloths assessing evidence for carnivory and the consumption of proteins of animal origin by means of amino acid compound specific isotope analyses, as suggested by our preliminary results. Since xenarthrans (the mammal group including sloths, armadillos, and anteaters) represented 1/3 of overall species diversity in South American mammal communities until as recently as 10,000 years ago, a discovery that fossil sloths possessed ecologies differing from those traditionally attributed to them could radically alter understanding of the entire community structure of terrestrial fossil mammals on the continent through time. Stable isotope analyses represent powerful, morphology-independent tools to directly reconstruct animal ecologies, and to test this controversial hypothesis of carnivory. To confidently apply this technique, however, several underlying assumptions first need to be tested on modern sloths and other mammals. Thus, the study w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Exploring the Socioeconomic Impact of Equids in the Iron Age Near East' (CENTAURIA) under Horizon Europe.

assistant: **Objectives**

Since the late 2nd millennium BC, the area between the Caucasus and Zagros mountain ranges has served as a crucial hub for horse breeding. A significant challenge in studying this region has been the methodological bias favoring historical sources, which emphasize Eurasian nomadic rider groups as the exclusive drivers of horse breeding and trade in the Near East during the Iron Age.  By thinking through the concept of horse economy, an interconnected system of activities spanning animal husbandry, trade, military uses, metallurgy, animal training, and artistic practices, CENTAURIA seek to emphasize the multiplicity of horse breeding centres and how the development and expansion of this mobility technology relates to changes in socioeconomic relations within and beyond the mountainous regions neighbouring the advanced civilizations of Mesopotamia.Using a combination of archaeological and archaeogenetic data, the research seeks to uncover the complex social structures in which equids played a critical socio-economic role. CENTAURIA relies heavily on archaeological evidence, particularly horse burials  in the South Caucasus and northwestern Iran, to examine how the evolution of the significance of horses and other equids impacted social dynamics during the Iron Age.While drawing insights from historical records of empires like the Neo-Assyrian and Urartian kingdoms, as well as from the Eurasian nomadic groups, CENTAURIA's primary focus is on material culture. By integrating archaeogenetic data with archaeological evidence, the project contextualizes genetic information within specific cultural, historical, and geographic frameworks. In doing so, CENTAURIA challenges the dominant view of Eurasian nomadic rider groups as the sole drivers of horse breeding and trade in the Ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dynamic Near Field Imaging' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Dynamic Light Scattering is a widespread technique for measuring fluid properties in soft matter. It is used to investigate complex fluids, colloids, proteins, nano-particles, but also samples of bio-physical and medical interest. The advent of pixilated sensors like CCD cameras and fast computers allowed the design of different imaging techniques aimed at providing the same quantitative information. Dynamic Near Field Imaging (DyNeFI) is a family of novel optical techniques of this kind. Different variants of this new approach have been successfully designed and used for very refined measurements, nevertheless the soft matter community is not aware of this intriguing possibility. The proposed project aims at: increasing the measuring capabilities of DyNeFI by the integration of new measuring concepts, applying it to samples coming from different research areas thus providing new science and starting developing instruments which can be commercialized in a next future. Essentially the project can be divided into three modules: A) Investigation of the dynamics of the transition between capillary waves and non equilibrium fluctuations in a critical binary mixture undergoing phase transition in order to get deeper insight of the dissolution of an interface between two fluid phases and also provide a tool to measure the effective surface tension B) Application of the technique to micro-rheological measurements, in order to compare the Dy-NeFI technique with other tools for measuring the viscoelastic properties of complex fluids C) Extension of the technique to fast dynamics, through Micro Mirror Device concept, in order to overcome the major disadvantage of the technique, which is the limited ability to investigate fast dynamics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cognitive AutonomouS CAtheter operating in Dynamic Environments' in the context of a Seventh Framework call.

assistant: **Objectives**

Recent efforts in robotics and automation research have fostered the development of a wide variety of bio-inspired snake-like continuum robots. These robots require radically different controllers and control schemes compared to conventional rigid robots, but continuum control has not received significant attention in the scientific community. Robotic catheters are a particularly challenging specialization of continuum robots because the vascular tree surrounding the catheter is complex, delicate, deformable and highly dynamic. This challenge is further complicated by the limited visibility during the procedure. CASCADE will develop a unified control framework for continuum robots that can operate in complex and deformable environments and specifically in the cardiovascular system. The project will construct general mathematical descriptions of the continuum robot and its surroundings while model parameters will be identified during clinical operation. In cases where fusing pre-operative data with intra-operative sensors does not provide sufficient information to allow reliable decision-making, active sensing techniques will be adopted. An interface to the supervising surgeon will enable cognitive links between the operator and the continuum robot, facilitating complementary assistance during autonomous execution of surgical tasks. The interface will also be used for learning and robotic training and further for validation of techniques using identified clinical benchmarks. The resulting development will allow the control of local (interaction force / stiffness) and global (shape) robot states at an unprecedented level of detail. The developed skill analysis tools will be used to verify the achievable control performance of continuum robots in catheter procedures. In pa