RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Pilot using Independent Local & Open Technologies' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Accelerators provide the majority of performance in modern High Performance Computing (HPC) systems and are the fundamental building blocks for Exascale systems. The European PILOT (Pilot using Independent Local & Open Technology) will be the first demonstration of two ALL European HPC and High Performance Data Analytics (HPDA) (AI, ML, DL) accelerators, designed, implemented, manufactured, and owned by Europe. The European PILOT combines open source software (SW) and open and proprietary hardware (HW) to deliver the first completely European full stack software, accelerator, and integrated ecosystem based on RISC-V accelerators coupled to any general purpose processor (CPU) via PCIe Gen 5.0 or CXL 2.0. This pilot will  demonstrate key HPC and HPDA workloads and software stacks. The European PILOT is also the first to demonstrate an ALL European HPC ecosystem. The accelerators will be manufactured in the new European GlobalFoundries 12 nm advanced silicon technology and TMSC 7nm.The European PILOT combines cutting edge research utilizing SW/HW co-design to demonstrate HPC and HPDA accelerators running key applications and libraries in a full software stack including middleware, runtimes, compilers, and tools for the emerging RISC-V ecosystem. The European PILOT is able to produce a full stack (SW and HW) research prototype by leveraging and extending the work done in multiple European projects like: EPI, MEEP, POP2 CoE, EuroEXA, and ExaNeSt. This pre-production system can only be realized with a combination of existing IP, HW emulation using FPGAs, and real ASIC prototypes that demonstrate the full stack feasibility of the hardware and software. Finally, while the applications we use span AI to HPC, the aggressive ASIC implementation (chip size and small geometry) will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Continuous Digitalized Processes for Producing Biopharmaceuticals'.

assistant: **Innovation**

Biopharmaceuticals are essential for the medical treatment of diseases like immune deficiencies, cancer, and diabetes, and provide an indispensable component to the health care system worldwide, as showcased by mRNA vaccines in the recent pandemic. Despite this success, manufacturing is still based on traditional, outdated batch production technologies, and on process development procedures based on historical experience and empiricism leading to many inefficiencies, like very long values of time-to-market. There is an urgent need to introduce modern integrated, continuous, and fully digitalized production processes, to also cope with the upcoming cell and gene therapies and the emerging personalized medicine. I develop here revolutionary process development and operation methodologies to enable this.These are based on a Digital Twin, which includes the first continuous, integrated and fully digitalized plant for producing mRNA. The “engine” are innovative hybrid models for each unit of the plant, which are updated on real time through continuous learning techniques. These provide the predictive capabilities needed for monitoring and control, knowledge transfer, scenario analysis and experimental planning.I will develop a new generation of hybrid models and innovative machine learning algorithms and provide the experimental evaluation and validation of my methodologies. Other high precision continuous processes, like flow-chemistry for sustainable catalytic processes or microfluidics for the controlled synthesis of nanomaterials, will benefit from these results.I am a recognised pioneer in the scientific foundations of continuous operation in biopharma. This inspired me in developing this disruptive Digital-Twin-based methodology and cope with the associated high risk.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Optimising wetland restoration strategies to minimise methane emissions and maximise carbon uptake' (WETRES).

assistant: **Concept**

The aim of the WETRES project is to determine the greenhouse gas fluxes from restored wetlands to see how fluxes change if drained and degraded wetlands are restored. Restoring degraded peat soils is an attractive, but largely untested climate change mitigation approach. Drained peat soils used for agriculture or for peat extraction are often large carbon dioxide sources and will contribute to global warming. Therefore, restoring subsided peat soils to managed, impounded wetlands can turn these sources into carbon sinks. However, at present, the amount of scientific information available to guide such restoration decisions and assess the impact of these actions is still sparse and restoration outcomes can be low carbon uptake and high methane emissions. Therefore, the overarching goal of this project is to provide an experimental and theoretical understanding of how to restore wetlands with minimised methane emissions and maximised carbon uptake. To understand processes that regulate carbon sequestration efficiency and methane fluxes, there is a need to cover fields from the molecular level to the ecosystem level. To achieve that, multiple drivers, such as site-specific hydrology, legacy effects, soil chemistry, soil microbiology, vegetation development will be analysed in conjunction with greenhouse gas emissions.   This effort directly addresses the European H2020 priorities of sustainable rural development and lower greenhouse gas emissions, which will help to slow down climate change.


**Keywords:** carbon sequestration, methane, eddy covariance, wetland restoration, natural climate mitigation methods
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Impact of Intrapartum Antimicrobial Prophylaxis as an early determinant in Microbiome Development', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

During the last decades, changes in diet and lifestyle have increased the risk of non-communicable diseases in the western countries. It is known that once they are established in the childhood, they continue into adult life with the associated negative impact on health, quality of life and health care costs. The correct establishment of the intestinal microbiota (IM) at the beginning of life plays a key role in health, reducing risk of chronic disease. Some factors affecting this process have been studied; however, other like the intrapartum antimicrobial prophylaxis (IAP), in spite of been present on over 30% of total deliveries, have been much less studied. It is already known that at least 11 types of broad-spectrum antibiotics cross the placenta and reach the foetus. Given the increasingly evident relationship between early microbiota, later disease risk and the rising worries regarding antimicrobial resistances, there is an urgent need to assess the potential adverse consequences of IAP in the establishment of the IM and resistome. This project will be the first to study mechanisms orchestrating the impact of IAP on the neonatal IM establishment. The objectives are: identify the alterations induced by IAP in the neonatal IM development; identify the antibiotic resistance genes that the IM carried as consequence of IAP; study the potential role of infant feeding in the modulation of the microbiota after IAP administration and design of specific dietary strategies for minimising the impact of IAP on the IM establishment. Moreover, if the breast-milk exerts a protective role, it would help to strengthen the maternal breast-feeding recommendations. Following this study, doctors will be better able to address the consequences to make knowledge-based decisions about IAP
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel insights into DNA damage and stress responses in the nucleolus: Mechanisms and relevance for genomic (in)stability and cancer' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Incidence of grave pathologies including neurodegeneration and cancer increases in today’s aging European populations and new approaches to battle these diseases are required. Shared by these pathologies and premature aging syndromes is the enhanced DNA damage and genomic instability, likely causal phenomena that can be better understood by functional elucidation of the cellular DNA damage response (DDR) machinery and its defects. The central hypothesis of this project is that ‘nucleolar genome’ that contains many copies of rDNA genes, the repetitive and most highly transcribed genomic sequences essential for ribosome biogenesis and protein synthesis, may represent an exceptionally vulnerable ‘Achilles heel’ of our genome whose instability fuels aging and tumorigenesis. This project proposes to approach this problem by a combination of innovative cellular models and techniques including gene editing, proteomics and live cell imaging, to assess rDNA damage and the ensuing genomic instability in human cells exposed to exogenous (radiation, chemotherapy drugs) and endogenous (replication and transcription stress, ribosome biogenesis stress, activated oncogenes) insults and identify and functionally characterize signalling and ‘repair’ factors that guard nucleolar integrity and function. This proposal is timely due to the emerging concept of nucleolus as a sensor of diverse stresses and the fact that technological advances now allow analysis of the difficult-to-assess rDNA genes. The applicant is experienced in the DDR field and modern technologies, the receiving institute is among the world leading centers in DNA damage, cancer and cell stress research fields. These aspects, together with the large body of preliminary unpublished data makes this ambitious project feasible.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Application and Control of Widely Tunable Lasers in HD-WDM Networks'.

assistant: **Concept**

Main ObjectiveThe objectives are to demonstrate the potential of widely tuneable lasers for High Density -Wavelength Division Multiplexed (HD-WDM) networks, to explore a new network architecture taking advantage of the flexibility of such lasers and to develop advanced control, management and switching methods for widely tuneable laser modules.Technical ApproachThe main focus is on the development of control methods for widely tuneable lasers and their implementation in subsystems containing the lasers fully packaged with drive electronics and microprocessor control. The aim of the control is to obtain accurate wavelength settings and sufficiently pure and stable laser spectra. Two distinct routes for achieving this control will be investigated and compared. The look-up table control is based on laser characteristics (power, wavelength, etc. versus currents) stored on an EEPROM. The characteristics can be both under the form of extensive series of measurement data or based on simple physical models and a limited number of device parameters. Emphasis will be on control algorithms that require little characterisation and very fast programming and on automation of characterisation and parameter extraction.The feedback control is based on direct monitoring of wavelength, power, etc. during operation and using it as feedback in the control of the tuneable lasers. Particular attention will be paid to wavelength monitoring using stable optical filters. Hybrid control schemes with both look-up table and feedback based control will also be considered.Widely tuneable subsystems, including the above mentioned control methods will be developed and tested for use in the network demonstrator. The power, single mode stability, frequency stability and tuning accuracy will be investigat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Big Data 4 Better Hearts - Sofia ref.: 116074', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Despite remarkable progress in the management of cardiovascular disease (CVD), major unmet needs remain with regard to mortality, hospitalisations, quality of life (QoL), healthcare expenditures and productivity. Acute coronary syndrome (ACS), atrial fibrillation (AF) and heart failure (HF) are major and growing components of the global CVD burden. Optimal management of these conditions is complicated by their complex aetiology and heterogeneous prognoses. Poor definition at the molecular level and co/multi-morbidities form major challenges for the development and delivery of targeted treatments. This renders response to therapy unpredictable, with large inter-individual variation and, importantly, small or undetectable treatment effects in large trials of unselected patients.Today’s treatment guidelines still reflect the scientific constraints of an earlier era where clinical markers to guide therapy are limited to conventional risk factors and end-organ damage, and where the main endpoint in clinical trials is patient death. Hence, drug development pipelines from early target validation through to late post-marketing work have proven to be slow, expensive and high-risk: the chance of eventual approval for a CVD drug candidate in Phase I trials is 7%, the lowest of any disease category (shared with oncology) 2. Moreover, tolerability of medication and adherence to treatment show wide variations. There is thus a need for better definition of these diseases, their markers and endpoints (including better segmentation of current heterogeneous patient groups acknowledging underlying mechanisms and comorbidities) and of their outcomes/prognoses (including functional capacity and quality of life [QoL]).BigData@Heart’s ultimate goal is to develop a Big Data--driven translation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Resilient Investment for Sustainable Environments'.

assistant: **Objectives**

Nature-based solutions (NBS) are considered essential to solving the climate crisis. They have the potential to simultaneously address climate change, biodiversity loss and human wellbeing and development, by providing different ecosystem services. However, the typically small size of NBS projects, the difficulties to measure and monetize their co-benefits as well as the long time frame for investment returns and the risk profile, undermine their attractiveness for funding. In comparison to NBS alone, the combination of NBS and ecosystem-based approaches, physical measures and technological measures is able to provide measurable outcomes quicker, reducing the risk profile and facilitating faster implementation and long-time maintenance, broadening opportunities for ecosystem innovation and increasing investment attractiveness.Aiming for bankability-by-design, RISE-IN will assess a set of climate resilient solutions (CRS), including NBS and ecosystem- based approaches and physical measures, by mapping and quantifying their co-benefits and identifying innovative financing and investment opportunities accordingly. Co-creation and participatory processes with local stakeholders, including investors and businesses, will enable the screening of the most adequate solutions for each site, in terms of functionality and funding and within a framework of just resilience. The assessment will be complemented by 3 climate risk assessment models that will reduce uncertainty regarding risks associated with extreme events, water run-off and capital loss. RISE-IN will demonstrate this concept for flood management (most costly type of disaster in Europe) in Cesena (IT), Christchurch (NZ) and Póvoa de Varzim (PT). RISE-IN demonstrations will be further tailored for replication in Ghent (BE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'GEnerating extreme NEutrons for achieving controlled r-process nucleosyntheSIS'.

assistant: **Innovation**

The project aim is to perform the first direct measurements of neutron capture and beta-decay rates related to the “r-process” of nucleosynthesis. This process, based on squeezing at once multiple neutrons in a nucleus, is presently thought to be the main mechanism that forms the heaviest elements in our Solar System and in stars. At present, there are large discrepancies between the observed element abundances in stars and those found from simulations. It is speculated that this problem stems from the uncertainties in nuclear parameters, particularly in the plasma environment. These nuclear parameters have not been experimentally verified due to the too-low flux of current neutron facilities and the lack of means to create on-site hot and dense plasmas.Lasers are not the first thing that comes to mind as a neutron source, but with the upcoming ultra high-power laser facilities (Apollon in 2018 and ELI-NP in 2019), high-density and high-energy protons can be generated. Through spallation, these can then produce neutrons with the needed flux, a flux comparable to that found in Supernovae. To further emulate the astrophysical scenario, auxiliary lasers can be used to turn the target material into a plasma.In practice, this project will aim to measure neutron capture and beta-decay rates, as well as yields and abundances of the products of nucleosynthesis obtained by exposing heavy-ion targets to laser-produced extreme neutron fluxes. These targets will be either in a plasma or a solid state. In plasmas, we will investigate the effect of excited nuclear states, created by the plasma photons and electrons, on neutron capture. In solid targets, we will take advantage of the unique possibility of generating on-site unstable nuclei, and then re-expose them to the neutron beam
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Gamma Ray Burst – Supernova Connection and Shock Breakout Physics' to be submitted under Seventh Framework.

assistant: **Abstract**

Long gamma ray bursts (long GRBs) and core-collapse supernovae (CCSNe) are two of the most spectacular explosions in the Universe. They are a focal point of research for many reasons. Nevertheless, despite considerable effort during the last several decades, there are still many fundamental open questions regarding their physics.Long GRBs and CCSNe are related. We know that they are both an outcome of a massive star collapse, where in some cases, such collapse produces simultaneously a GRB and a SN. However, we do not know how a single stellar collapse can produce these two apparently very different explosions.  The GRB-SN connection raises many questions, but it also offers new opportunities to learn on the two types of explosions.The focus of the proposed research is on the connection between CCSNe and GRBs, and on the physics of shock breakout.  As I explain in this proposal, shock breakouts play an important role in this connection and therefore, I will develop a comprehensive theory of relativistic and Newtonian shock breakout. In addition, I will study the propagation of relativistic jets inside stars, including the effects of jet propagation and GRB engine on the emerging SN. This will be done by a set of interrelated projects that carefully combine analytic calculations and numerical simulations. Together, these projects will be the first to model a GRB and a SN that are simultaneously produced in a single star. This in turn will be used to gain new insights into long GRBs and CCSNe in general.This research will also make a direct contribution to cosmic explosions research in general. Any observable cosmic explosion must go through a shock breakout and a considerable effort is invested these days in large field of view surveys in search for these breakouts. This