RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Idealist2027: Transnational NCP Project for Digital Innovation and Support' to be submitted under Horizon Europe.

assistant: **Abstract**

The Idealist2027 vision is to supply the National Contact Points (NCPs) responsible for digital destinations in Horizon Europe with the tools, knowledge and expertise they need to better serve the digital research community applying for funding from Horizon Europe.Through transnational collaboration, synergies with other digital programs and other cluster 4 NCPs networks, and special network activities Idealist2027 will enhance NCP capacities to facilitate stronger, more impactful European projects.The project focuses on four key objectives:1.Bringing NCPs to a common understanding of the EU digital landscape, future digital trends, policies, and funding opportunities.2.Lowering barriers for newcomers, particularly SMEs and widening countries, ensuring broader engagement in digital initiatives and creating better impact on the digital landscape.3.Connecting digital communities to foster collaboration and knowledge-sharing among stakeholders.4.Integrating the components of Cluster 4 to benefit NCPs, applicants, and stakeholders through synergies across Digital, Industry, and Space.Idealist2027 introduces new services, such as the Horizon Intelligence task, which will analyze Evaluation Summary Reports (ESRs) to provide data-driven insights to NCPs, enabling them to better guide proposers, and will continue to offer very successful services such as Idea check and proposal check. By building on the experience of previous Ideal-ist projects and fostering cooperation within Cluster 4, Idealist2027 will create a more cohesive and supportive environment for NCPs and their stakeholders.The project will ensure compliance with the FAIR principles for data management and will collaborate closely with other Cluster 4 NCP projects. Idealist2027 aims to strengthen the European digita
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Methodological foundations of the Europeanisation process in private law - positive, negative and instrumental legal integration' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content In response to the frequent critiques of opaque and far-reaching European law intrusions into national legal systems, this thesis tries to methodologically recontruct the different forms of interplay between the two legal orders, with a view to alleviating frictions and enhancing legal certainty. Furthermore, by drawing on a common core of methodological and substantive elements of all European private laws, it will promote a renaissance of a European ius commune and of a common European legal science. To the above ends, in Part I, three basic categories, partly adopted from integration theories, will be elaborated: positive, negative and instrumental legal integration. Part II on positive integration deals with the gradual genesis of EC private law and is aimed at promoting system-building within it (by synthesising common features, e.g. the concepts of consumer and good faith, within the already existing directives and by making recourse to a common core of European private law as formulated in the Lando principles in gap filling). Part III on negative integration tries to conceptualise the direct impact of EC law on domestic private law by reconstructing, in the light of conflict of laws techniques, the ECJ's famous doctrines on direct effect, supremacy, preemtion, direct effect of directives, 'directive-conforming' interpretation of national law, and state liability. Part IV on instrumental integration will instead provide an exhaustive picture of all the positive regulatory tasks that EC law imposes on domestic private law: the legislative implementation of directives, the supplementation of EC law (including sanctions of violations) and the recognition of foreign law, as developed in the famous Cassis jurisprudence and adopted in th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Diagnostic and Antibiotic Stewardship for Urinary Tract Infections Using Fit-for-Purpose Diagnostic Tools' (UTI-Diag).

assistant: **Innovation**

Urinary Tract Infections (UTIs) and antimicrobial resistance (AMR) pose significant global health threats, characterised by high incidence and mortality. However, in Sub-Saharan Africa (SSA), there is often a lack of accessible diagnostics to guide proper treatment and therapy monitoring. Our objectives are as follows: (1) Develop and validate a two-tier diagnostic toolbox: (a) Implement a Lateral Flow Test (LFT) for detecting urinary biomarkers at primary care for triage; (b) Deploy a compact, portable Point-of-Care (POC) instrument for secondary care (hospitals, clinics), integrating pathogen detection via isothermal nucleic acid amplification and host-response biomarker quantification for evidence-based therapy and antibiotic prescription; (c) Introduce novel (self)-sampling cards for transport without the need for a cold chain; (d) Establish a digital health platform for clinical decision support. (2) Evaluate the toolbox's field deployability, acceptance, usability, and integration into clinical practice. (3) Maximise the adoption, implementation, and accessibility of the proposed diagnostic toolbox. (4) Prepare for post-project regulatory approval and market launch. (5) Enhance capacity building and surveillance structures through local manufacturing transfer and improvement of the supply chain and logistics. We will recruit diverse patient groups, including under-represented segments of society, from various African settings to ensure the broad applicability, sustainability, and customisability of our solutions. This project is expected to have a significant impact, improving the quality of UTI/AMR diagnostics, reducing unnecessary antibiotic use, preventing resistance, strengthening health systems and their response to epidemics, and increasing accessibility and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Beyond Light Imaging: High-Rate Single-Photon Detection in Four Dimensions' in the context of a Horizon 2020 call.

assistant: **Objectives**

Goal of the 4DPHOTON project is the development and construction of a photon imaging detector with unprecedented performance. The proposed device will be capable of detecting fluxes of single-photons up to one billion photons per second, over areas of several square centimetres, and will measure - for each photon - position and time simultaneously with resolutions better than ten microns and few tens of picoseconds, respectively. These figures of merit will open many important applications allowing significant advances in particle physics, life sciences or other emerging fields where excellent timing and position resolutions are simultaneously required.Our goal will be achieved thanks to the use of an application-specific integrated circuit in 65 nm complementary metal-oxide-semiconductor (CMOS) technology, that will deliver a timing resolution of few tens of picoseconds at the pixel level, over few hundred thousand individually-active pixel channels, allowing very high rates of photons to be detected, and the corresponding information digitized and transferred to a processing unit.As a result of the 4DPHOTON project we will remove the constraints that many light imaging applications have due to the lack of precise single-photon information on four dimensions (4D): the three spatial coordinates and time simultaneously. In particular, we will prove the performance of this detector in the field of particle physics, performing the reconstruction of Cherenkov photon rings with a timing resolution of ten picoseconds. With its excellent granularity, timing resolution, rate capability and compactness, this detector will represent a new paradigm for the realisation of future Ring Imaging Cherenkov detectors, capable of achieving high efficiency particle identification in enviro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Optimised 2 Mw wind turbines in high wind speed area with smooth grid integration' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Demonstrate the durability, reliability of large scale (2MW) variable speed wind turbines with improved performance (5% increase in electricity output) in a high wind speed area (9.8m/s at hub height), resulting in production costs of 0.041/kWh. Demonstrate innovative conversion of wind generated electricity to ensure reduced negative impacts on the electricity network.The innovation relates to optimised reactive power control, rapid reaction to wind turbulence and active oscillations and harmonics management. Demonstrate additional increase in electricity production by adjusting re-start wind speed threshold (currently set at 20m/s) following turbine cut-out (at 25m/s) using a fuzzy logic approach incorporating historic wind velocities, gusting data and wind energy forecasting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Communities Under Siege:  Everyday Challenges in the Divided City of Jerusalem'.

assistant: **Concept**

Social (in)justice is a key issue in today’s cities, which are characterized by growing  socio-economic inequalities. Divided cities—such as Jerusalem and Nicosia—experience further tensions in light of their unstable geopolitical condition. While divided cities have been studied from a number of angles, little is known of the daily challenges that divided communities experience at the neighbourhood scale. This research proposes to study divided communities in East Jerusalem to examine the pressures that they experience and to elucidate the strategies they employ to better off their lives. Situated in the realm of urban planning, the study focuses on four key issues: a) governance, b) local leadership), c) housing, and d) municipal services, infrastructure and public space. The project utilizes diverse methods including interviews, focus groups, on-site visits, and mental maps to study the dynamics of integration and exclusion in three Palestinian and Israeli-Palestinian East Jerusalem neighbourhoods.This project involves an Advisory Board composed of experts in the fields of urban studies and political science, providing scholarly expertise and access to the research area. The project will be disseminated through scholarly publications and conference presentations. Moreover, a public outreach programme has also been designed to communicate the findings  to local communities, NGOs, and policy makers. In addition, local Palestinian students will be  participate in research activities. The project will advance the training of the Fellow, enabling her to reach a position of  independence through learning new methods, mentoring students, and leading the planning and execution of the project. Findings from the research would extend beyond the particular status of divided cit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Universal 3D printer bioink for Type 1 diabetes cell therapy' (UNIINK) targeting Horizon Europe.

assistant: **Abstract**

Type 1 Diabetes (T1DM) results from autoimmune destruction of pancreatic insulin-producing -cells. Nowadays, insulin injections remain the leading therapeutic option. However, injection treatment fails to emulate the highly dynamic insulin release that -cells provide. During the last years, 3D cell-laden microspheres have been proposed as a major platform for bioengineering insulin-secreting constructs for tissue graft implantation and a model for in vitro drug screening platforms. Current microsphere fabrication technologies have several drawbacks: the need for an oil phase containing surfactants, diameter inconsistency of the microspheres, and high time-consuming processes, among others. These technologies have widely used alginate for its rapid gelation, high processability, and low cost. However, its low biocompatible properties do not provide effective cell attachment. To overcome these limitations, Uniink proposes a high-throughput 3D bioprinting methodology that employs an ECM-like microenvironment for effective cell-laden microsphere production. Crosslinking the resulting microspheres with tannic acid (TA) prevents collagenase degradation and enhances spherical structural consistency while allowing the diffusion of nutrients and oxygen. In addition, the approach allows customization of microsphere diameter with extremely low variability. In conclusion, we will develop in Uniink a novel bio-printing procedure to fabricate large amounts of reproducible microspheres capable of secreting insulin in response to extracellular glucose stimuli. We expect that Uniink will represent a valid alternative to islet transplantation in T1DM patients, thus bringing cell therapy closer to the application in humans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Variational Methods for Dynamic Inverse Problems in the Life Sciences'.

assistant: **Innovation**

This project will develop novel techniques for solving inverse problems in life sciences, in particular related to dynamic imaging. Major challenges in this area are efficient four- dimensional image reconstruction under low SNR conditions and further the quantification of image series as obtained from molecular imaging or life microscopy techniques. We will tackle both of them in a rather unified framework as inverse problems for time-dependent (systems of) partial differential equations.In the solution of these inverse problems we will investigate novel approaches for the following aspects specific to the above-mentioned problems in the life sciences:1. Solution of inverse problems for PDEs in complex time-varying geometries2. Development of appropriate variational regularization models for dynamic images, including noise and motion models3. Improved forward and inverse modelling of cellular and intracellular dynamics leading to novel inverse problems for nonlinear partial differential equations4. Construction and implementation of efficient iterative solution methods for the arising 4D inverse problems and their variational formulationAll tasks will be driven by concrete applications in biology and medicine and their success will be evaluated in applications to real problems and data. This is based on interdisciplinary work related to electrocardiology and developmental biology. The overall development of methods will however be carried out in a flexible and modular way, so that they become accessible for larger problem classes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Role of Cdc42 in cancer cell adhesion to endothelial cells and platelets' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Metastasis accounts for 90% of cancer deaths, and it is therefore important and timely to identify new therapeutic targets aimed specifically at metastasis. Cdc42 has recently been implicated in a key step of the metastatic cascade: the extravasation of circulating tumour cells, also termed transendothelial migration (TEM) . This project aims to study how Cdc42 contributes to breast cancer cell TEM in vitro and in vivo. Cdc42 regulates β1‐integrin expression via the transcription factor serum response factor (SRF) and thereby stimulates cancer cell adhesion to endothelial cells (ECs) and TEM. To analyse the molecular basis for this regulation, downstream targets of Cdc42 will be depleted by RNAi in a panel of breast cancer cells to determine which target/s are responsible for altering β1‐integrin expression, adhesion to ECs or TEM.Cancer cells interact with platelets as soon as they enter the bloodstream, and this enhances cancer cell TEM in vivo. It is therefore possible that Cdc42 regulates attachment to platelets as well as ECs. The role of Cdc42 in the interaction between platelets and cancer cells will be tested by adding purified platelets to control or Cdc42‐depleted breast cancer cells in vitro and analysing platelet aggregation around cancer cells by confocal microscopy. The role of Cdc42 in platelet attachment to cancer cells during early lung colonization in vivo will be studied by intravenous injection of fluorescently tagged breast cancer cells in mice.This project will increase our understanding of metastasis. The identification of molecular targets involved in cancer cell extravasation will provide a starting point for the development of new drugs, thus contributing to reduce the mortality of patients with metastasis.


**Keywords:** Rho GTPases, integrin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Charge transfer at Nanofunctionalised Interfaces' (CTNFI) under Sixth Framework.

assistant: **Objectives**

The objective is to investigate charge transfer processes in three important nanoscale systems, using a range of novel measurement techniques, and to understand how charge transfer can be controlled and regulated by design at the nanoscale. Interfacial cha rge transfer is an essential aspect of nanoscale (molecular) electronics, and related fields, and there is currently much interest in organic, polymer and supramolecular systems as integral components in devices.Three important nanoscale systems will be i nvestigated:1) nanoparticle and conducting polymer/nanoparticle composite films;2)supramolecular nanowires comprising redox-active metallo-cyclodextrin hosts and metalloguests with terpyridyl ligating units;3) single-walled carbon nanotube (SWNT) devices.Highlights of the programme include: examining the effect of organisation on the conductivity of nanostructured thin films using a novel combination of scanning electrochemical microscopy (SECM) in a Langmuir trough; functionalising surfaces with molecular wires and measuring the relationship between the force of chemical interaction in the wire and conductivity, using conducting-atomic force microscopy (C-AFM); making electrochemical sensors from individual SWNTs and probing their local reactivity with combined SECM-AFM. The proposed investigations will provide a unique opportunity to examine the relative merits of different types of nanoscale system and to carry out several types of new measurements and experiments, which could have a major impact worldwide.The fellowship will provide an opportunity to collaborate and meet with some of the world and apos;s leading experts in interfacial nanoscale science, and to learn advanced skills in SECM, C-AFM and SWNTs, as well as extending and broadening my experience of met
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Development of a readout circuit for a resonant accelerometer'.

assistant: **Concept**

The purpose of the present project is to develop an ASIC implementing a readout interface for a resonant accelerometer. It is developed in response to the requirements described in the Clean Sky call for proposals referenced under CS-2012-01-SFWA-01-046 and the specifications the topic manager will provide at the beginning of the project. Resonant accelerometers offer the advantage over capacitive ones to be less sensitive to radiations, which makes them ideal candidates for harsh environments applications. Whereas capacitive accelerometers exploit the change of capacitance of an element such a MEMS when it is subject to acceleration, resonant accelerometers detect the shift of the resonant frequency of a device when it is subject to acceleration.The consortium is composed of two partners, CSEM and HMT, which both have a long track record in the design of integrated circuits apart from having complementary expertise, covering all the aspects of the project. CSEM has a recognized experience in low power and low voltage design of analogue and digital circuits, as well as wide competencies in the design of complex System-on-Chip (Soc).. HMT is specialized in ""mixed signal"" ASICs and modules, particularly for sensors and actuators in highly demanding fields.""