RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A MULTI-SPECTROSCOPIC APPROACH TO PROBE  AMYLOID AGGREGATION AT BIOLOGICAL SURFACES' (MultiSpecAMYLOID).

assistant: **Concept**

Treatment of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s syndrome, is one of the biggest challenges of nowadays medicine. The success of the curing strongly depends on our understanding of chemical processes involved in developing these diseases. From a chemical point of view, these diseases are determined by uncontrolled neuropathological alterations such as aggregation of proteins and formation of insoluble fibrils, called amyloids. It is of paramount importance to fully understand the fibril formation on a molecular level in order to find ways how to inhibit the protein aggregation.In the proposed research we focus on the aggregation of Aβ peptide, which is associated with Alzheimer’s disease. Although substantial knowledge on the aggregation process of Aβ peptide in the bulk solution exists, the influence of the cell membrane on this process is poorly understood due to the lack of surface specific techniques. Here we propose to study the aggregation of Aβ peptide at the surface of model lipid membranes with advanced surface specific spectroscopic methods: vibrational sum-frequency generation (VSFG) and shell-isolated nanoparticles-enhanced Raman spectroscopy (SHINERS). Such combined spectroscopic approach will enable to determine the molecular structure of the aggregates at every step of the fibril formation and to reveal the role of the membrane. Altogether the proposed research will give relevant insights by which membrane and various co-solutes promote the aggregation process.The candidate, Dr. S. Strazdaitė has returned to her home country after PhD studies in the Netherlands. She is currently employed as a senior research fellow in the Centre for Physical Sciences and Technology (FTMC) at Prof. Gediminas Niaura group. The researcher will bri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Implementation of an Integrated Digital Health System for Infectious Diseases  in Maternal and Child Health In East Africa' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The adverse consequences of infectious diseases, including HIB, hepatitis B, malaria, tuberculosis, syphilis, sepsis, and other poverty-related infectious diseases on pregnant and breastfeeding women and children are well recognised. We aim to scale up  the LINDA-FAMILIA eRegistries, an innovative, interoperable, and adaptable open-source digital health information system within the DHIS2 platform (District Health Information Software), replacing paper-based systems in maternal and child health units in the following four regions in East Africa: Addis Ababa Region, Ethiopia; Eastern Province, Rwanda; Kilimanjaro, Tanzania; and Lango sub-Region, Uganda. The four regions have varying clinical and digital readiness needs and challenges. The system is designed to strengthen the health systems using 11 digital health interventions which were selected following WHO guidelines. The system will support clinical research by gathering harmonised longitudinal maternal and child  data. The system will support epidemiological clinical research such as trialling vaccines at a low cost by using the real-world routinely collected data. This will speed up the production process of effective vaccines, other preventive measures and allow patients to access treatment and interventions and inform the development/improvement of clinical guidelines and health policies. The LINDA-FAMILIA proposal is in line with national digital health strategies in the four countries and the East Africa Digital REACH Initiative. Our proposal addresses the relevant public health short- and mid-term actions of the AU-EU Innovation Agenda 2023, including enabling improved equitable access to essential healthcare and providing the opportunities to create an international research hub and enhance sustainable globa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Evasion of antitumor immunity and immunotherapy by melanoma extracellular vesicles'.

assistant: **Concept**

Melanoma is the deadliest of the skin cancers. Immune checkpoint inhibitors (ICI), which are blocking antibodies that help to restore antitumor immunity, are currently used for the treatment of metastatic melanoma. However, only approximately 20% of the patients respond to ICI. Understanding the molecular mechanisms behind the resistance to these therapies is essential to predict patients' response and increase treatment success. Extracellular vesicles(EVs), nanosized structures released by virtually all cells, are key mediators of cell-cell communication and horizontal transfer of biomolecules locally and systemically. EVs are known to play an important role in cancer biology by regulating cell apoptosis, angiogenesis, antigen presentation and immune modulation. In recent years, EVs have been shown to also act as protein-decoys, through binding and sequestering soluble proteins, thus preventing protein-target interactions. Previous work from the host group shows that EVs excreted by melanoma cell lines express interferon-γ receptor (IFNGR). Thus, we hypothesize that melanoma-derived EVs modulate the bioavailability and activity of this cytokine. Preliminary results show that EVs isolated from mouse metastatic melanoma B16-F10 cells express IFNGR, bind to IFNγ, and protect tumor cells from the cytotoxic effect of IFNγ. Because resistance to antitumor immunity and to ICI has been linked to defects in IFNγ signaling, this project aims to investigate whether IFNGR+ EVs downregulate IFNγ signaling and ICI response. This research has the potential to unveil a novel yet overlooked cancer immune evasion mechanism mediated by IFNGR+ EVs, which may provide crucial insights to optimize current cancer therapies and ultimately improve patient outcomes.


**Keywords:** Extracellular
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Comparing the properties and the consequences of attainment versus maintenance goals' (AttMain) targeting Seventh Framework.

assistant: **Abstract**

Economic and social behavior is often goal directed. People and organizations can strive for two kinds of goals: They can strive for an improvement of the current state (e.g., increase the balance of a savings account-an attainment goal), or they can strive for holding on to the current state (e.g., maintain the balance of a savings account -a maintenance goal). Research to date has studied attainment goals in isolation, but it has rarely compared the properties and processes associated with attainment versus maintenance goals. As a consequence of the absence of such systematic comparisons, our understanding of maintenance goals remains limited, and our understanding of attainment goals incomplete. Recent academic research comparing the two goal types indicates that they hold different properties. However, many important questions remain open: Are attainment or maintenance goals more attractive, and under what circumstance? What types of plans are more appropriate for the pursuit of each goal type? Is individual performance affected differently by the two goal types? Under what circumstances? Are independent versus interdependent cultures more inclined towards one of the two goal types? Answering these questions is the objective of the proposed research program. Providing these answers will require a combination of laboratory and field studies. Hence, the results will be compatible with the experimental psychology tradition in goals’ research, and relevant for the field of behavioral economics.  Moreover, given the importance of goals in several research domains (e.g., marketing, consumer behaviour, management, psychology) and real world contexts (e.g., saving, dieting, work, investments, charities) the results of the proposed research program are expected to affect a v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sustainable urban development laboratory' in the context of a Fifth Framework call.

assistant: **Objectives**

SUDLAB will provide city managers with information about the relative performance of their area on a range of measures of sustainable urban development (SUD), and the factors influencing future SUD including policy and technological drivers. Solutions generated by KA4 projects and from wider city experience will be presented. SUDLAB will support KA4 projects by identifying the 'markets' for the products, and promoting their application. SUDLAB will provide a web based service powered by a database and team of content managers, which will be validated by Trial City users and policy experts. The capability of the database will enable users to generate reports relevant to policy choices, based on comparisons and scenario testing, at lower than current costs. SUDLAB will be developed in stages, with prospective users closely involved in testing and relate to the roll out of FP4 projects and EU level policy priorities. SUDLAB will be market tested and developed to become self-financing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'STRUCTURAL RELIABLE OFFSHORE FLOATING PV SOLUTION INTEGRATING CIRCULAR CONCRETE FLOATING BREAKWATER' (SUREWAVE).

assistant: **Concept**

SUREWAVE will develop and test an innovative concept of Floating Photo-Voltaic (FPV) system consisting of an external floating breakwater structure acting as a protection against severe wave-wind-current loads on the FPV modules, allowing increased operational availability and energy output, thus unlocking the massive deployment of Offshore FPV. It will be focused on the research for securing optimal behaviour at aero & hydrodynamic and structural integrity level of the external breakwater, the internal FPV modular structure, the connections, the mooring and anchoring and the whole FPV system, complying with mechanical, electrical (maximizing energy output) and cost-efficiency requirements, ensuring high lifetime of critical components, high reliability of the system and easy, quick and cost-efficient, construction, installation and O&M of the whole system.This will require:1) the development of novel circular concrete material solutions for the breakwater, cost-effective, easy to produce and with high mechanical, physical and durability properties and low CO2 footprint.2) the development of an advanced predictive computational modelling and simulation framework: coupled aero & hydrodynamic modelling, Structural integrity modelling, material properties modelling and Structural Health Management to reduce CAPEX and OPEX;3) the design and implementation of an optimal testing and validation methodology for offshore FPV system to achieve TRL5, including lab testing, basin-model testing and marine environment testing of critical components assuring high resilience to corrosion and biofouling.Maximum advantage of existing expertise will be taken from experts in: offshore wind floating structures, material and phenomena modelling (SINTEF, MARIN, CEIT), design and installation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Droplet-wall-interaction phenomena of relevance to direct injection gasoline engines (DWDIE)'.

assistant: **Innovation**

Objectives: Direct Injection Spark Ignited (DISI) engines are superior to other SI engines in terms of fuel efficiency and CO2 emissions. The topic of DISI engine hydrocarbon requires a new consideration of the problem of droplet wall interaction. Wall films and pools of un-burnt fuel formed by spray or droplet wall impingement is a major source of hydrocarbon emissions. To allow the effective design of DISI engines with respect to mixture formation, CFD tools are indispensable. These CFD codes commonly make use of Eulerian-Lagrangian methods for spray simulation and require appropriate droplet wall interaction models. It is the goal of this project to derive a general droplet wall interaction model applicable to the entire range of conditions present during operation of DISI engines. Description of the Work: Eulerian-Lagrangian methods track individual droplets along their trajectory until the droplets either evaporate, leave the simulation domain or impinge on a wall boundary. In the latter case correlations are required that link the pre and post-impingement conditions of a droplet and secondary droplets respectively. The special conditions in a DISI engine cylinder, i.e. small droplets, high temperatures and a wide range of pressures, do not allow for simple extrapolation of the results of numerous earlier investigations. Since a complete set of information is required for CFD simulations simultaneous measurements of droplet number, size, velocity vector and temperature in the hemisphere above the impact location, plus the resulting wall heat flux, are necessary. The project covers single droplet impacts, droplet chains, monosized sprays and finally polydisperse sprays and considers in particular the relevance of wall temperature and gas phase pressure. This measure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Constrained Low-Rank Matrix Approximations: Theoretical and Algorithmic Developments for Practitioners', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Low-rank matrix approximation (LRA) techniques such as principal component analysis (PCA) are powerful tools for the representation and analysis of high dimensional data, and are used in a wide variety of areas such as machine learning, signal and image processing, data mining, and optimization. Without any constraints and using the least squares error, LRA can be solved via the singular value decomposition. However, in practice, this model is often not suitable mainly because (i) the data might be contaminated with outliers, missing data and non-Gaussian noise, and (ii) the low-rank factors of the decomposition might have to satisfy some specific constraints. Hence, in recent years, many variants of LRA have been introduced, using different constraints on the factors and using different objective functions to assess the quality of the approximation; e.g., sparse PCA, PCA with missing data, independent component analysis and nonnegative matrix factorization. Although these new constrained LRA models have become very popular and standard in some fields, there is still a significant gap between theory and practice. In this project, our goal is to reduce this gap by attacking the problem in an integrated way making connections between LRA variants, and by using four very different but complementary perspectives: (1) computational complexity issues, (2) provably correct algorithms, (3) heuristics for difficult instances, and (4) application-oriented aspects. This unified and multi-disciplinary approach will enable us to understand these problems better, to develop and analyze new and existing algorithms and to then use them for applications. Our ultimate goal is to provide practitioners with new tools and to allow them to decide which method to use in which situation and to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'SMART POwder and Products'.

assistant: **Innovation**

Plant biomass represents a quasi-unlimited reservoir of functional elements, which are buried within large macrostructure assemblies. Extreme comminution of plant materials is a way to reveal emergent functionalities that can be exploited in highly technical applications such as smart materials designed by additive manufacturing. This dramatic size reduction induces physical and chemical changes whose interconnections have not yet been investigated. The concept of the SMART POP project is to exploit them to prepare powders with enhanced functionalities and flowabilities. By stirring these powders into a polymeric matrix, the final aim is to design, using 4D-printing, environmentally friendly materials that can react to environmental stimuli. By using direct and reverse engineering approaches, the SMART POP project will explore two functionalities that the biomass powder could provide to the materials from grafted-molecules : a fluorescent response to an environmental stimulus and the control of the degradation of the matrix thanks to delayed acid hydrolysis reactions. These functionalities will be studied in close interaction with the different processing steps and related to flowability of the powder. The originality of the SMART POP project relies on a strong interdisciplinary (chemistry, physics, engineering, etc.). Its achievement will be possible thanks to the broad scientific background of Dr Claire Mayer-Laigle and the facilities & skills developed by the host team in SCION Institute (NZ) since more than 10 years. During the outgoing phase, the host team will train Dr Claire Mayer-Laigle to numerous additive manufacturing technologies and conjoint innovative developments are expected. The return phase in the beneficiary institute (INRA) will be devoted to the tra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Lead free automotive SLI power' (LEFAPO) targeting Horizon 2020.

assistant: **Abstract**

This project contributes to the call’s overall objective, which is to stimulate the competitiveness of eco-innovative SMEsseeking to launch their products on world markets. This project introduces an eco-innovative product, a car-starting battery,which contains no hazardous materials, extends battery life at least six times longer (in start-stop life) compared to lead-acidbatteries, and produces significant CO2 savings.Olife has developed a new car battery that is a milestone in the evolution of the automotive industry. It is the first fullsubstitute for lead-acid batteries and offers many advantages, such as: superb performance, light weight, high range ofoperating temperatures, ideally suited to start-stop systems, superior reliability and durability, resistance to extremevibration, starting ability up to 90% DOD (depth of discharge), lead and acid free, non-hazardous and eco-friendly.The business innovation project aims to complete the development and to demonstrate industrial readiness and maturity forprimary market introduction (the new vehicle market), to build brand awareness, develop communication and disseminationactivities for both the primary market and the aftermarket. This objective will be accomplished via three key steps:1) Testing, modification and finalisation of product development for OEM market2) Communication and dissemination activities3) Protection of intellectual propertyThe current battery market, due to LAB (lead-acid battery) technology limitations, offers a wide variety of batteries of differentcapacities. Olife's offering (L2 and L5) successfully meets major market requirements.• The L2 Olife battery is equivalent to a 55Ah LAB battery.• The L5 Olife battery is equivalent to a 110Ah LAB battery.Patent applications have been already submitted
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Effects of silvicultural regimes on dynamics of genetic and ecological diversity of european beech forests', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Traditional forest management of European beech forests consists of large-scale felling with a few remaining trees to produce the next generation. This may have significantly disturbed the genetic and ecophysiological diversity. In general, high diversity is assumed to be very important for the adjustment to environmental changes. DynaBeech aims to assess the impacts of silvi-cultural regimes on genetic and ecological diversity. It will result in guidelines for both the optimisation of the adaptive potential and in situ conservation of beech forests through appropriate silvi-cultural regimes. These will be obtained through the integration of genetic and ecophysiological results by modelling and the development of alternative management scenarios. End-users involved in the project will evaluate the guidelines for economic and practical implications in their field of forest management.