RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unravelling mammalian mechanosensor diversity by functional genomics' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Mechanotransduction is the signaling by which external mechanical stimuli are converted into biological signals within the cell. It helps to probe and map the rigidity and texture of external world and appeared with the first life forms some 3.8 billion years ago. In mammals, many fundamental physiological functions are regulated by mechanotransduction.The somatosensory system is involved in the perception of touch, pain and proprioception. Molecular mechanosensors of this sensory system are mechanically-activated ion channels. These channels are expressed at the nerve endings of sensory neurons that project long axons to the skin and to deeper body structures. The identification of these channels constitutes one of the most important challenges in the field of sensory transduction. So far only one gene family has been unambiguously associated with mammalian mechanosensory function and is specifically involved in light-touch sensation. Therefore, the identity of mechanotransduction channels involved in the detection of other mechanosensory modalities including proprioception and mechanical pain remain to be determined.We will combine patch-clamp methodology and single-cell transcriptome sequencing to generate the specific expression profile of distinct populations of mouse mechanosensitive neurons. Combination of bioinformatics, expression analysis and electrophysiological approaches will be used to identify molecular components of mechanotransduction channels. We will explore the role of identified genes in somatosensory functions.The long-term objective is to provide a compelling view of mechanosensitive process diversity in mammalian somatosensation through molecular identification of mechanotransduction channels and characterization of their physiological functions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Models of Practice in the Management of Occupational Safety and Health Risks During the Pre-Construction Phases of Construction Projects' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The construction industry (CI) across the EU has a depressing record of fatal and non-fatal accidents. Researchers have reported that reductions of 42-60% in construction accidents are achievable through better design decisions and coordination at pre-construction phase. EU Directive 1992/57/EEC is aimed at improving the management of occupational safety and health (OSH) risks in the CI. It therefore prioritises coordination during the pre-construction phase by requiring national laws to mandate the appointment of a Pre-Construction Phase Coordinator (PCPC). Statistics on UK accidents have sparked debate as to the efficacy of the transposition of the Directive into national law, particularly the provisions on the PCPC, referred to in the current legislation as the Principal Designer. This challenge has resonance across the entire EU. The proposed action is aimed at developing knowledge and understanding of roles and practices in the management of OSH risks at the pre-construction phase towards the ultimate research output in the form of an advanced pre-construction OSH risk management simulator. These outputs will deliver improvements in OSH which, even at 1%, could mean 3706 fewer accidents, equivalent to €43M annual savings. The research will adopt a mixed methodology involving document analysis, focus groups and case studies to determine practice and industry opinion on identified issues. Research informants will comprise experienced construction professionals and expert OSH practitioners. The action will provide knowledge-exchange opportunities between industry and academia, and stimulate practitioner debate on current OSH policy, leading to changes in professional practice and better training of professionals. The Fellow will be the nexus of these exchanges and wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European Children's Future University Network - www.universiYOU.net', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

ECFUN builds up the virtual platform www.universiYOU.net by bringing together local activities and experiences of European Universities and Foundations that try to attract children's and young people's interest in science. The aim is to provide didactically outstanding scientific content for children deriving from underrepresented groups and build up a future network - both in cyberspace and real life. The virtual platform www.universiYOU.net provides the opportunity for children to learn more about what the scientific world is based upon. It will encourage them to take up further studies in science and will make research visible in a manner that is attractive, innovative and exciting for them. Main goal is to share the fascination of putting things in question - in a scientific way. Furthermore, biographies of female and male European scientists will serve as role models with respect to the target group. Interactive discussion boards and forums will provide an opportunity for children to personally get in contact with scientists and also to communicate with other children with similar interests all over Europe. Main message is that science is not only for a preferred minority, rather that it concerns all people in their everyday-life. Children experience that they can deal with science. Latent barriers that arise from (gender) stereotyped assumptions concerning science and scientific careers can thus be eliminated. The main target group are those who have not had any chance to get in touch with the academic world yet. They will be given the option to learn more about the excitement of science and about future possibilities for them in science as profession. The project will outturn in 6 European languages, spoken by 10 million children aged between 9 and 12 years all o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Understanding the role of microglia in neurodevelopmental disorders' (2021-2027).

assistant: **Innovation**

Neurodevelopmental disorders like autism (ASD) and Fragile X syndrome (FXS) are associated with changes in microglia function and synaptic pruning. No approved or effective therapies exist for FXS/ASD. Novel therapies are needed that target microglia, distinct from conventional drugs targeting neurons. Research on synaptic pruning mediated by microglia is scarce, and the role of microglia in FXS/ASD has been overlooked. Previous studies, including my own work and studies from the host laboratory, however, advanced approaches for analysis of microglia-synapse interactions and demonstrated that the abnormal pruning may be associated with the Integrated Stress Response (ISR) pathway since the elevated phosphorylation of eIF2α is linked to neuroinflammatory disorders characterized by excessive synapse loss. Thus, impaired microglial eIF2α phosphorylation may decrease synaptic pruning, highlighting eIF2α as an attractive target for restoring synaptic pruning in FXS/ASD. My project aims to uncover microglia's contribution to FXS/ASD pathophysiology. First, I will address how the FXS/ASD state affects synaptic pruning by microglia, microglial morphology, and function. Second, I will explore the role of microglia and FAM69, a novel kinase mediating eIF2α phosphorylation, in impaired synaptic pruning at the molecular and cellular levels. Genetically engineered mice and human brain organoids will facilitate visualization and targeting of microglia-synapse interaction. To assess changes in synaptic pruning, I will use viral vector-assisted silencing and overexpression of microglial FAM69, validating their impact on synaptic pruning by vital two-photon microscopy. Finally, I will evaluate whether these interventions can alleviate autism-like behavior. With this integrative approach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Automatic SaaS Governing of Hybrid Networks for Growing Infrastructure Demands', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The cost of network failure in SMEs is over $20,000 per hour; 70% of SMEs could not survive for more than 24 hours without their critical IT infrastructure and many struggle to recruit skilled IT staff. Many network outages can be prevented with a full-scale IPAM (IP Address Management) solution; IPAM solutions manage the corporate network more efficiently leading to less network downtime, less manual troubleshooting, and faster provisioning of new network locations and services. Most large corporates already have an IPAM solution to manage their networks. As more and more SMEs are moving part of their networks to public clouds and as Internet of Things is expected to massively increase the number of connections to enterprise networks, SMEs networks will become hybrid, complex to manage and with enormous number of connected devices. IPAM solutions will become a must-have for SMEs, as such complexity is impossible to manage manually. Current IPAM solutions are expensive, reside on the local network and require effort in deployment and expertise that is often beyond the reach of SMEs IT staff. ASGARD is a revolutionary SaaS (Software-as-a-Service) IPAM solution that will provide unprecedented ease-of-use in deployment and extremely user-friendly network management capabilities to SMEs and large corporations with a special focus on the complexity of hybrid networks (both local and cloud based) and IoT. ASGARD takes seconds to deploy and no network administration expertise is required. It is affordable and scales-up with the organization. Founded in 1990, Men  Mice have been developing IPAM solutions for a long time. We understand the necessities and the opportunities in the IPAM market better than anyone. Among Men  Mice customers are well known global enterprises, institu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Super-HEART: a fault-tolerant and highly efficient energy hub with embedded short-term energy storage for high availability electric power delivery' (Super-HEART), addressing dissemination and exploitation.

assistant: **Impact**

Power electronics (PE) is spreading through society, including in mission critical applications. However, PE devices are prone to failure, and high availability is usually ensured using redundancy - which is expensive and bulky. In the meantime, PE allows hybrid (AC & DC) electric distribution, which is key to integration of solar power and use of hydrogen as energy carrier. But loads can be affected by the limited dynamics of power sources like fuel cells and by disturbances carried by the network.With Super-HEART, we want to build an energy hub connecting power sources and load, and able to deliver uninterrupted power. To this end, we will develop a multi-port modular converter with fault ride-through capability. This will be ensured using fault-tolerance strategies already proved in the ERC PoC Project ""U-HEART"", improved by the integration of supercapacitors (SC) to allow using reliable and low-cost mechanical switches to isolate the faulty parts instead of semiconductor switches, leading to a significantly higher TRL. Super-HEART will use SC also for compensating disturbances and the low dynamics of hydrogen-based storage. But commercial SC have power and energy densities too low to be practically considered here. Therefore, previously developed high-performance and environment friendly SC will be further optimised in this project and embedded in the converter by optimal co-design.In parallel to the technological development, we will prepare the monetisation of the IP, comprising a market analysis, the development of solid business model and tech-to-market transition plan, and the search for clients and partners.Ultimately, a power converter with embedded SC with availability, power density, cost, and losses, 20% better than state-of-the-art will have been develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Revolutionary solution to unlock concrete-to-concrete circularity' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

C2CA, a spin-out of TU Delft, is transforming the construction industry by upcycling waste concrete into a low-carbon cement substitute, addressing the urgent challenge of reducing CO2 emissions from cement production. Cement accounts for 8% of global emissions, yet its low-cost, availability, performance and versatility make it essential and much desired. Reducing these emissions has been challenging—until now.C2CA’s breakthrough process converts low-value waste concrete into high-quality, low-carbon materials, particularly a highly reactive cementitious binder. Unlike competitors who downcycle concrete into low-grade aggregates, C2CA produces premium materials to replace cement, delivering both environmental benefits and commercial viability. Our low-carbon cement competes on cost and quality with traditional alternatives like fly ash and slag, which are being phased out. While new options like calcined clay and mine tailings are costly or energy-intensive to produce and transport.By 2024, C2CA has developed its core machines on an industrial scale, processing over 1,000 tons of waste concrete. Our materials have been validated in multiple pilot projects, proving technical and commercial viability. The next milestone is building our full-scale upcycling plant.EIC funding is essential for advancing our project, which requires significant capital and has long lead times. Proving our plant’s reliability is crucial for commercial rollout, but we encounter technical, regulatory, and market risks that complicate investment, including energy price volatility and a preference for traditional materials. With the EIC support we can overcome the barriers, complete our flagship plant, demonstrate our technologies at an industrial scale, and build a comprehensive testing facility.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Visible-light-driven Photocatalytic CO2 Reduction to Solar fuels by multinary N-Graphene based Heterostructure Composites'.

assistant: **Innovation**

Energy shortage and environment pollution are two critical threats faced by the present society. Carbon dioxide (CO2), the well known greenhouse gas is a major cause of global warming but at same time it is also an abundant resource for hydrocarbon energy fuels. Photocatalytic  CO2 reduction (PCO2R) into sustainable solar fuels is a highly enticing challenge for simultaneous settling of energy and environmental issues. So far, manifold photocatalysts including inorganic semiconductors, noble metal complexes, metal organic frameworks, 2D nanomaterials etc. have been demonstrated potential candidates for CO2 photo reduction. But the overall catalytic performance of the state of art materials is still far from practical application due to one or combined problems of low conversion efficiency, poor light harvesting, low stability, high electron-hole recombination rates, high cost and lack of product selectivity. Thus there is a steady demand for high performance photocatalysts preferably multinary heterostructure designs that can compensate for the shortcomings of the single components. The PCO2R project aims to develop novel multinary N-doped graphene based heterostructure composites decorated with titanium dioxide semiconductor, gold-copper bimetallic nanoalloys and/or transition metal dichalcogenides-copper nanoparticles as robust high efficiency photocatalysts for visible light reduction of CO2. The heterostructure composite is custom designed to overcome the major existing challenges and is anticipated to have great potential as a practically useful photocatalyst that can reduce CO2 under irradiation of visible light along with high product selectivity. The PCO2R project will confer significant scientific advances in the field of materials design, synthesis and catalys
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'INTEGRATED REGIONAL DEVELOPMENT SUPPORT SYSTEM' (IRDSS) under Fourth Framework.

assistant: **Objectives**

The aim of IRDSS is an integrated set of telematics applications for isolated under-privileged communities to develop their full potential through network links to more central regional economies. Inter-regional economic cooperation will be based on downward decentralisation of work and services to these marginalised localities. The core technology will act as a base for thematic modules accessed via public user-friendly multimedia kiosks, or from home on the Internet. The project is expected to boost effective economic planning, interregional business activity and improved regional government for urban and local communities.The aim of the project is to provide an integrated set of telematic applications that will enable geographically, economically and socially marginalised communities and groups to develop the full potential of their areas, and to help connect their economies to those of more central regions and to the emerging Information Society.The specific objectives of the proposal are to:- Begin to build the telematic tools to empower local communities to construct a physical, economic, environmental and social model of their localities.- Construct a framework for the decentralisation of work and distribution of services from regional to local level.- Lay the telematic foundations for the economic and developmental interaction of geographically distant localities and regions in the future.The users targeted by this project fall into two groups, ie,- Local community/development groups, businesses and citizens- Regional AdministratorsBoth of these groups have separate but complimentary needs. The core technology used in the proposed application is Geographic Information Systems (GIS). This will act as a base upon which a number of key thematic modules will be over
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Electron Spin Resonance Nano-Imaging for the Analysis of Semiconductor Devices'.

assistant: **Innovation**

The semiconductor industry is a multibillion-dollar endeavor situated at the heart of the modern world. During the development and production of semiconductor devices things can go wrong, and the source of the problems must be analyzed. This is the impetus for another large industry aimed at providing methods for failure analysis (FA) of semiconductor devices.   FA systems make use of a variety of sophisticated techniques that provide a wealth of information at very high spatial resolutions. However, current techniques have limitations, especially regarding the non-destructive measurement of the internal structure and material composition of the devices.Electron spin resonance (ESR) is a well-established technique for the characterization and imaging of paramagnetic materials. In semiconductors, ESR has been used extensively to study paramagnetic properties such as crystal impurities, defects, and dopants that greatly affect the devices’ performance. However, conventional ESR has very limited sensitivity and image resolution, making it unattractive for the study of the sub-micron-scale devices that are in use today. Our current ERC project has recently resulted in a method that improves ESR sensitivity by about 3 orders of magnitude compared to commercial systems. We also enhanced the spatial resolution of ESR-based images to the 100-nm length scale. Such capabilities heighten ESR’s attractiveness as a potential semiconductor-inspection tool. The purpose of the proposed project is to develop a demonstration prototype of a one-sided ESR imaging probe based upon this new methodology. This probe will examine semiconductor wafers and analyze their properties, composition, and structure in a non-destructive manner. We will also provide market research on the field of FA and