RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Functional Characterization of Redox Switches in Mitochondrial Metabolism' in the context of a Horizon Europe call.

assistant: **Objectives**

Reactive oxygen species (ROS) are increasingly recognized as important regulators of cellular signaling, with hydrogen peroxide acting as a key mediator through reversible protein oxidation (redox switches). Mitochondria are the major source of ROS during oxidative phosphorylation, and disturbances in redox balance are a hallmark of mitochondrial diseases, which contribute to both rare inherited disorders and common conditions such as neurodegeneration and cancer. Despite advances in diagnosis, therapeutic progress remains limited, in part because the molecular mechanisms linking mitochondrial dysfunction, redox signaling, and disease progression are poorly understood. This project, MitoSwitch, addresses this knowledge gap by investigating how redox regulation shapes mitochondrial metabolism. I will generate redox proteomic data using two complementary approaches: (i) a model of mitochondrial disease with disrupted redox balance, and (ii) spatially resolved oxidation patterns reflecting local mitochondrial activity. Selected candidate oxidations will then be functionally assessed to identify novel redox switches controlling mitochondrial metabolism. By bridging cellular and tissue-level perspectives, MitoSwitch will advance our understanding of redox biology, reveal molecular mechanisms underlying mitochondrial disease, and deliver broadly applicable methodologies for studying redox regulation in health and pathology.


**Keywords:** Redox Biology; oxidative post-translational modification; mitochondria; mitochondrial disease; single cell deep visual proteomics (scDVP);
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dressing Robotic Assistants for Persons with Reduced Mobility' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Physical disabilities due to illness, injury, or ageing can alter the way a person moves around the house, manipulates objects and senses their home. These issues make it harder for persons to execute daily home activities on their own, and therefore specialized professionals are required to take care of them. However, the growing elderly population and the persons having basic activity difficulties or suffering from long-standing diseases are saturating the health systems due to insufficient infrastructures and over-demand for health carers. Robotics-based solutions are a promising alternative to support the human labour at health care. This project focuses on how robotic assistants can be exploited to provide independence and empower people with different kinds of mobility problems. Specifically, the main goal is to assist these persons in dressing themselves, which has been found to be an important task for independent living. In this sense, a robotic dressing assistant needs to skilfully manipulate clothes, physically interact with the human, recognize his/her intentions and actions, and easily adapt to changes in the clothing, user posture, and degree of mobility of the assisted person. These highly complex features are tackled in this proposal from a robot learning perspective, in which programming-by-demonstration, reinforcement and interactive learning will be combined to create both sophisticated manipulation skills and safe assistance behaviours. The proposal envisions three different real experimental scenarios to test the proposed approaches and show their performance with real (able-bodied) participants (with restricted motion). This project will not only advance the state of the art in assistive robotics, robot learning and human-safe control, but also wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Hardening and Softening of Borders: Challenges for Europe and the World' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

LIMES is a doctoral programme for 13 talented PhD candidates in the domain of the humanities and social sciences, centredon the theme of ‘The Hardening and Softening of Borders: Europe in a Globalising World’. The dynamics of ‘softening’ and‘hardening’ borders have become key issues in social and political transformations. Conducting research within thisframework means working on the frontline of societal and scientific innovation, and is therefore particularly attractive for anew generation of interdisciplinary researchers. Moreover, Maastricht – located in the heart of the transnational Meuse-Rhine Euroregion – offers excellent opportunities to function as springboard for the mobility of ESRs. The programmeensures that its graduates are well-equipped for the job market, within and outside academia. A rich training programme andtailor-made secondments at one of the external partners are geared towards extending the employability of LIMESgraduates far beyond traditional options.


**Keywords:** Social Sciences, Humanities, Cross-border, Interdisciplinarity, Transnational Mobility, International, Intersectoral, Employability, Secondments, Doctoral Training
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'willpower – make your own fuel from CO2' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Our vision: we want Europe to be independent of fossil fuels. To turn this ambitious dream into reality, Gensoric targets in a first step a sector which accounts for more than 73% of the fossil fuel usage and 57% of all CO2 emissions in the EU: heating!To overcome this situation, Gensoric aspires to empower private uses to change things actively by themselves. As a means for that, the company introduces ist willpower system: the worldwide first residential CO2 utilization system. It empowers its users to their produce fuel at home from the surrounding atmospheric CO2. The core technology is a patent protected and widely validated electro-biocatalytical process and process technology that runs under ambient conditions.As it uses primarily energy from renewable sources such as installed solar panels or micro wind turbine, the system can also be used as an effective way to store energy from the renewables, but it has a greater capacity than power packs and batteries.During the previous SME-1project its potential to disrupt the conventional energy supply chains was confirmed. Moreover, the market potential  of more than 7 bln Euro in alone in Western Europe and the underlying business model (‘ink cartridge’)  attracted strategic partners such as one of Germany’s leading energy and utility company, with access to 30 million customers across Europe, who will take over the market introduction once the pilot project has been completed successfully. Outcome of the here proposed SME-2 project is a market ready system with an overall efficiency of 45% and an average capacity to reduce 11kg of CO2 emission per day and user.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Production of a movie to accelerate the uptake of innovative bioenergy technologies for heating and cooling' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The EU has put considerable effort in creating a favourable legal framework for renewables (RES). However, RES heating and cooling has so far received less political attention. This market sector is heavily dominated by biomass (>98% share). New and innovative techniques for biomass heating and cooling are available that are environmentally safe and make biomass increasingly easy to handle. Uptake of these technologies is lagging, however, and a main factor of the EU's under-performance on the way to its 12% RES target. Main objective of BIOENERGY IN MOTION is to increase the uptake of new and innovative biomass heating & cooling technologies and systems in the EU, by strengthening the market confidence of specific target groups (end-users, investors, government authorities) in the EU in general and in three target countries (Bulgaria, Czech Republic and Estonia) in particular.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A novel drug discovery method based on systems biology: combination therapy and biomarkers for Multiple Sclerosis' to be submitted under Seventh Framework.

assistant: **Abstract**

The therapeutic challenge of complex diseases requires the use of combination therapies to target the distinct mechanisms and pathways involved. Such complex diseases will benefit from the design of computational models adopting a systems perspective to integrate the knowledge generated by ‘omics technologies and clinical data. Multiple Sclerosis is a prototypic debilitating complex disease in which an autoimmune attack is launched against the brain. Current therapies for MS are far from effective and target only part of the immune response. Hence, the need to develop combination therapies with good safety profiles that better control this condition, the main aim of CombMS. By understanding how current MS therapies work in biological networks and taking advantage of novel compounds, more effective combination therapies will be designed for MS. Indeed, the tools developed will be applicable to other immune and complex diseases to improve their therapeutic options in the future. The data for the modelling process will be generated from biological and clinical samples, and the predictions about combination therapies from the computational models tested using in vitro and animal models of MS. Given the limitations of animal models in translational research, we shall focus on studying the phosphoproteome in samples from individuals with MS (PBMC) using xMAP technology. The phosphoproteome has been identified as a system likely to be affected in MS and the novel therapeutic compounds that will be tested are known to act through signalling pathways involving receptor tyrosine kinases. The mechanistic modelling will be extended to the different levels of the response to therapy by analysing biological networks integrating gene and protein networks, with drugs, their effects and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Analysis of MassIve Data STreams', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The objective of AMIDST is to develop a toolbox providing a scalable framework that facilitates efficient analysis and prediction based on information captured in streaming data. The work includes developing and scaling up existing algorithms in order to make the AMIDST toolbox flexible and versatile enough as to cope with the needs and requirements of a wide variety of applications. The toolbox will be particularized to address three industrial use-cases. Each use-case solution will be used to rigorously test the framework on real and complex data.The consortium has a strong and balanced combination of research and industrial partners. The academic partners ensure a scientific approach to theoretical and methodological aspects of the project. The industrial partners illustrate the importance of the potential developments provided by AMIDST for the EU economy, as they represent four strategic EU areas: software development, automotive industry, energy, and finance. AMIDST will make significant contributions towards the expected impacts of the call objectives. It will provide a generic framework for analysis of extremely large volumes of streaming data, thereby adding, creating and increasing the value of existing and new data resources as well as providing a means for more timely and efficient decision making. Each use-case solution represents an important contribution to its application domain.The industrial and commercial involvement in AMIDST ensures a high degree of commercial exploitations of the solutions developed. Each use-case represents one domain of commercial exploitation of effective solutions whereas the general framework will be applicable to a wide range of other domains. With the objective of creating a strong positive synergy, AMIDST takes an integrate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Host Protective Engineering of Cancer Immunity by Targeting the Intracellular Immune Checkpoint NR2F6'.

assistant: **Innovation**

Because of its biological complexity, cancer is still poorly understood. Chronic inflammation has been shown, both experimentally and epidemiologically, to be a predisposition to, and also an inseparable aspect of clinically prevalent cancer entities. Therefore, a detailed understanding of both tumour and immune cell functions in cancer progression is a prerequisite for more successful therapeutic startegies. My team was the first to reveal the lymphocyte-intrinsic PKC/NR2F6 axis as an essential signalling node at the crossroads between inflammation and cancer. It is the mission of this project to identify molecular signatures that influence the risk of developing tumours employing established research tools and state-of-the-art genetic, biochemical, proteomic and transcriptomic as well as large scale CRISPR/Cas9 perturbation screening-based functional genomic technologies. Defining this as yet poorly elucidated effector pathway with its profoundly relevant role would enable development of preventive and immune-therapeutic strategies against NSCLC lung cancer and potentially also against other entities. Our three-pronged approach to achieve this goal is to: (i) delineate biological and clinical properties of the immunological PKC/NR2F6 network, (ii) validate NR2F6 as an immune-oncology combination target needed to overcome limitations to ""first generation anti-PD-1 checkpoint inhibitors"" rendering T cells capable of rejecting tumours and their metastases at distal organs and (iii) exploit human combinatorial T cell therapy concepts for prevention of immune-related adverse events as well as of tumour recurrence by reducing opportunities for the tumour to develop resistance in the clinic. Insight into the functions of NR2F6 pathway and involved mechanisms is a prerequis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Imaging fear of painful touch: unraveling relationships between neural correlates of pain-related fear, somatosensory neuroplasticity, and sensory impairments in the context of chronic pain.'.

assistant: **Innovation**

Chronic pain affects > 20% of people worldwide leading to enormous personal suffering and economic burden. A key factor contributing to chronic pain disability that thus far has been neglected is fear of painful touch - a core symptom in people with complex regional pain syndrome (CRPS). FABrIC (FeAr of painful touch in the BraIn in Chronic pain) is a functional Magnetic Resonance Imaging (fMRI) study using a novel tactile fear conditioning paradigm. I will examine the neural correlates of acquisition, generalization and extinction of fear of painful touch and interrelationships with somatosensory neuroplasticity, and sensory impairments in individuals with CRPS compared to healthy controls. Also, I will investigate how individual differences in vulnerability and resilience factors can modulate fear learning and how they affect pain-related outcomes. This MSCA project is groundbreaking and can yield novel insights in hypothesized intertwined underlying neural mechanisms of pain-related fear and relations with symptoms. I will uniquely and necessarily bridge the gap between different disciplines and pain researchers from physiotherapy, neuroscience, and psychology fields studying the same complex chronic pain disorder. Persons with CRPS endorsed the relevance of this project, which provides opportunities to alleviate the CRPS stigma and improve treatments based on newly gained insights. Maastricht University and the interdisciplinary outstanding research groups are ideal to perform this fellowship. The host developed and pioneered the tactile fear conditioning paradigm. This fellowship will provide the exceptional chance to synergistically combine my expertise of chronic pain and quantitative sensory testing with neuroscientific, neuroimaging, and threat-safety-learning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ultrasensitive chiral detection by signal-reversing cavity polarimetry: applications to in-situ proteomics, single-molecule chirality, HPLC analysis, medical diagnostics, and atmospheric studies' (ULTRACHIRAL).

assistant: **Concept**

Chirality is a fundamental property of life, making chiral sensing and analysis crucial to numerous scientific subfields of biology, chemistry, and medicine, and to the pharmaceutical, chemical, cosmetic, and food industries, constituting a market of 10s of billion €, and growing.Despite the tremendous importance of chiral sensing, its application remains very limited, as chiroptical signals are typically very weak, preventing important biological and medical applications. Recently, the project-coordinating FORTH team has introduced a new form of Chiral-Cavity-based Polarimetry (CCP) for chiral sensing, which has three groundbreaking advantages compared to commercial instruments: (a) The chiroptical signals are enhanced by the number of cavity passes (typically ~1000); (b) otherwise limiting birefringent backgrounds are suppressed;(c) rapid signal reversals give absolute polarimetry measurements, not requiring sample removal for a null-sample measurement. Together, these advantages allow improvement in chiral detection sensitivity by 3-6 orders of magnitude (depending on instrument complexity and price). ULTRACHIRAL aims to revolutionize existing applications of chiral sensing, but also to instigate important new domains which require sensitivities beyond current limits, including: (1) measuring protein structure in-situ, in solution, at surfaces, and within cells and membranes, thus realizing the “holy-grail” of proteomics; (2) coupling to high performance liquid chromatography (HPLC) for chiral identification of the components of complex mixtures, creating new standards for the pharmaceutical and chemical analysis industries; (3) chiral analysis of human bodily fluids as a diagnostic tool in medicine; (4) measurement of single-molecule chirality, by adapting CCP to mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ESTABLISHMENT OF A CENTER FOR INTELLECTUAL PROPERTY AND TECHNOLOGY TRANSFER  (CIPTT) IN THE FORMER YUGOSLAV REPUBLIC OF MACEDONIA' (CIPTT) targeting Seventh Framework.

assistant: **Abstract**

The purpose of the requested Marie Curie IRG is to assist Dr. Bratislav Stankovic in his permanent professional reintegration into his native country, the Former Yugoslav Republic of Macedonia (FYROM). Dr. Stankovic has spent 19 years in the USA as a researcher, scholar, educator, and law practitioner, acquiring professional experience in both the academic and private sectors. He recently accepted employment as a full-time faculty member at the University American College (UACS) in Skopje. The award of an IRG should assist Dr. Stankovic to share in his native country his knowledge and expertise in intellectual property (IP) rights, technology transfer (TT), science, and socio-economic development.He has already developed expertise and track record in IP law, technology and knowledge transfer, both as a scholar and as a law practitioner, working for one of the largest IP law firms in the USA. He is keenly aware of the global developments in IP law and TT. An award of an IRG would be instrumental in supporting his efforts to create an interdisciplinary Center (CIPTT) intended to promote a strategic focus on innovation in, and development of, various industries - and to enhance commercialization of research. The long-term goal of this effort relates to promotion and enablement of innovation, intellectual asset management, fostering the creation of new technologies, tools, SMEs, and paradigms in the FYROM.The CIPTT will have a strong intersectoral aspect, bringing together experts from diverse areas such as law, economics, science, business, and education, thus combining a unique set of partner skills.The establishment of the Center will be an incremental yet important step in the positioning of FYROM as a place of smart, sustainable and inclusive growth built upon an econo