RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Extracellular adenosine role in energetic metabolism during immune response' (2007-2013).

assistant: **Innovation**

Immune response is energetically demanding process and although an improper regulation of energetic metabolism during immune challenges leads to various complications in human patients it is largely unknown how is the energetic metabolism regulated during the immune response. Extracellular adenosine is a strong candidate for this type of regulation; nevertheless it has never been studied for such role. Our work using Drosophila as a model strongly supports the view of adenosine being the signal connecting energy reallocation with immune response. The regulation of extracellular-adenosine levels and its signaling are now well defined in flies and the model allows various manipulations with the adenosine system in vivo. Therefore the model is now perfectly suitable for a systematic analysis of the adenosine regulation of energetic metabolism during various infections which should lead to a better understanding of the energetic costs of mounting an immune response. Results of such analysis could greatly contribute to our knowledge of host-pathogen interactions and some highly important biomedical problems. Goal of this project is for the applicant to learn the complex methodology of Drosophila infections and use these obtained skills for the systematic analysis of the adenosine role during immune response.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advancing beyond the adaptive radiation paradigm: uncovering the contributions of adaptive and non-adaptive processes to a rapid plant radiation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Understanding why some lineages rapidly generate exceptionally high species diversity (undergo rapid radiation) lies at the heart of our understanding of biodiversity and is a key question in biology. Adaptation to different ecological niches together with rise of phenotypic diversity is considered to trigger rapid radiations. However, existing studies fail to test the alternative (or null) hypothesis, namely that a rapid radiation is driven by non-adaptive processes mediated by geographic isolation of lineages with similar ecological niches. In order to uncover the contributions of adaptive and non-adaptive processes to a rapid radiation, I will focus on the radiation of Dianthus in Eurasia, the most rapid plant radiation known. RadiPhyte aims at developing a novel, integrative perspective on evolutionary radiations, beyond the narrow focus on adaptive radiations, to unravel the driving forces in this plant radiation. RadiPhyte will focus on three key aspects: phylogenomics, ecological niche modelling, and phenotypic trait evolution, and will encompass species from the biodiversity hotspots across the Mediterranean mountains and from the semi-arid/arid mountains of Irano-Anatolia, Caucasus and Central Asia which are not only highly biodiverse but severely understudied and threatened by climate change. RadiPhyte combines the strengths of the host in ecological genomics of adaptive processes in Dianthus, with those of the applicant in phylogenetics, ecological niche modelling, and geometric morphometrics. RadiPhyte will thus promote a two-way transfer of knowledge between the host and the applicant and create important synergies. RadiPhyte comprises a comprehensive dissemination strategy, and is in line with the “climate change action in developing countries with fragile
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Danube Wetlands and flood plains Restoration through systemic, community engaged and sustainable innovative actions' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

DAnube WETlands REStoration (DaWetRest) Lighthouse is designed to develop and demonstrate (pilot) concrete solutions applied on the Danube basin to address the challenges faced by its inland and coastal wetlands ecosystems’, namely on (i) biodiversity, (ii) water quality and availability, (iii) climate resilience and/or neutrality and (iv) socio-economic benefits for the local communities. These transformative and innovative solutions will be validated by local communities and main Regional and European-wide stakeholders.DaWetRest has the role to prepare and plan the replication, deployment and scaling up of the validated innovative solutions for the next mission’s phase. For this important scope, DaWetRest project proposes several strong ideas, such as (i) building and selecting interventions based on extensive and prior know-how (sibling sites and non-EU experiences), (ii) local, regional and basin scale integrated interdependent analysis of results from the planned interventions, (iii) merge DaWetRest own data, models and digital tools with existing and future ones, towards a centralized knowledge centre in the future and (iv) involve the managing authorities and a number of local actors in the entire process, from the very beginning. Thus, DaWetRest results will accelerate and generalize the deployment of innovative solutions in the second phase of the Mission.The demonstration of innovative and result-oriented solutions is organized in 3 DEMOs - DEMO Middle Danube (MD), DEMO Lower Danube (LD) and DEMO Danube Delta (DD). Each DEMO offers main intervention sites, pilots, sibling locations, replications, platforms/services, local stakeholders engagement and methodologies to strengthen the innovation, knowledge and cooperation in and beyond DaWetRest in Danube basin an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Computational Perspective to Dynamical Protein-Lipid Complexes under Crowded Conditions' (CROWDED-PRO-LIPIDS), addressing dissemination and exploitation.

assistant: **Impact**

One of the great challenges is to understand how cellular functions emerge in cell membrane systems. Unlocking this mystery is the key to the vast majority of human diseases. The current view is based on a static picture where membrane proteins in protein-poor membranes interact with a few specific lipids, while in reality the situation is much more complicated. This ambitious project aims for a breakthrough by changing the present paradigm. The objective is to focus on the dynamical interplay between lipids and proteins under crowded conditions, paving the way for understanding the dynamics of lipid-protein complexes and their resulting functions. The objectives are outstanding and contain a high risk, with exceptional gain. The main goal is better understanding of the physical principles that give rise to cellular functions, with a strong impact to clarify the relevance of dynamical lipid-protein interactions in cellular processes related to health and disease. For this purpose, the grand themes chosen for this project are lipoproteins coupled to cardiovascular disease (“good” and “bad” cholesterol) and the function of especially cholesterol and glycolipids with membrane proteins. In order to meet these goals, the applicant employs state-of-the-art simulation techniques that comprise quantum-mechanical, classical atomistic and coarse-grained simulation methods to elucidate the complex biological phenomena associated with lipid-protein systems. The simulations cover atomistic and molecular details, over time scales from femtoseconds up to milliseconds. The theory & simulation group lead by PI comprises expertise in a truly cross- and multi-disciplinary manner, and it strongly collaborates with some of the leading experimental teams in biomedical sciences, cell biology,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deformation Mechanisms are the Key to Understanding and Tayloring Tribological Behaviour' to be submitted under Horizon 2020.

assistant: **Abstract**

Tribology, the science of interacting surfaces in relative motion, is crucial for many aspects of modern life. Friction and wear decisively impact the lifetime and durability of many products-from nanoelectromechanical systems to gears and engines. In the USA alone, an estimated 1E18 joules of energy could be saved each year through improved tribological practices.During sliding of a metallic contact, a mutated surface layer forms, carries most further plastic deformation and largely determines friction and wear. The origin and evolution of this distinct subsurface layer remains elusive, since our knowledge of the elementary mechanisms promoting these changes is limited. Only this knowledge however will allow for a strategic tailoring of tribologically loaded metals.In this project, we will elucidate these elementary mechanisms for a wide range of alloys and strain rates. We will develop ground-breaking new strategies for probing the subsurface microstructure during the tribological test itself with non-destructive testing sensors like ultrasound and eddy current, resulting in subsurface in situ tribology. The data from these sensors will be analysed online, during the tribological experiment, relying on cutting edge data science methods as they have already been applied for fatigue testing. Based on these analyses, implemented on a Field Programmable Gate Array, we will interrupt the test exactly when the dominating elementary mechanisms manifest themselves. These mechanisms will then be revealed by sophisticated electron microscopy and be visualized in deformation mechanism maps for unidirectional and reciprocating sliding. Such maps have proven very successful in other fields of materials science, e.g. creep at elevated temperatures. They are used to guide material s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'MULI BUSLORRY WITH MULTIPLE USE GOODS AND PASSENGER TRANSPORT'.

assistant: **Innovation**

- Reduction of the investment costs for the service by joint use of vehicles (public transport/commerce) or by joint service of goods transport (express/parcel delivery) and public transport in greater urban areas as well as in rural areas.- Reduction of both fuel and emissions by the use of :* alternative engines powered by natural gas - CNG* small vehicles instead of large ones* avoidance of trips by joint service.- Innovation : joint use of a vehicle for passenger and goods transport, usage of smaller and fewer vehicle thus energy saving in the transport sector.- The MULI-Buslorry is in operation since January 1998 in Berlin and Feb. 1998 in Sweden.- The operation experiences in Berlin and Älvsborg show that the operation concepts run without difficulties.- Several technical problems occured with the gas driven MULI-Buslorry in Berlin. The vehicles unsatisfying availability created problems especially for the goods transport operator. This showed that a substitute vehicle is necessary and should provided in similar demonstrations.- The vehicles is well accepted by the drivers of goods and passenger transport.- The new public transport services provided by the MULI-Buslorries in Älvsborg line bus appreciate the vehicle comfort.- Considerable problems occured with the licencing of the vehicles in Sweden. Despite the MULI-Buslorries run by gas meet the common European safety standards the Swedish authorithies denied the approval of the gas driven engine of the MULI-Buslorry up til now.- An exemption from the Swedish National Road Administration was applied for in March. The exemption decision was delayed until September 1998 and then denied. - This shows that the technical requirements for gas vehicles in Europe should be harmonized.The MULI project is a demonstration p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A SiPM upgrade for VHE Astronomy and beyond', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Ground-based gamma-ray astronomy in the Very High Energy (VHE, E>100 GeV) regime has fast become one of the most interesting and productive sub-fields of astrophysics today. Utilizing the Imaging Atmospheric Cherenkov Technique (IACT) to reconstruct the energy and direction of incoming gamma-ray photons from the universe, several source-classes have been uncovered by previous and current generations of IACT telescopes (e.g. Whipple, MAGIC, HESS, VERITAS).The next generation IACT experiment, the Cherenkov Telescope Array (CTA) will provide increased sensitivity across a wider energy range and with better angular resolution. However, research into new and improved technology for potential upgrades of the CTA system are already being considered. Improving the light-collection efficiency (hence reducing the energy threshold) and field-of-view of CTA cameras is high on the agenda of future upgrades. One may also consider increasing the number of telescopes if the cost of the cameras could be significantly reduced. The primary path to these goals is to replace PhotoMultipliers (PMTs) with Silicon-PMs (SiPM). These new photodetectors will also find multi-disciplinary use in e.g. in fluorescence telescopes for detection of Ultra High Energy Cosmic Rays and PET scanners in medical physics.However SiPMs are not yet mature enough to replace PMTs for several reasons: sensitivity to unwanted longer wavelengths while lacking sensitivity at short wavelengths, small physical area, high cost and electronic noise. Here we propose a novel method to build relatively low-cost SiPM-based pixels utilizing wavelength-shifting material which overcome some of these drawbacks by collecting light over a larger area than standard SiPMs and improving sensitivity to shorter wavelengths while reducing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Desertification in the aral sea region : a study of the natural and anthropogenic impacts.'.

assistant: **Innovation**

The state of the Aral Sea and the surrounding lands constitutes one to the worst environmental disasters that the world has ever seen. As the lake has shrunk, as a re-salt of increasing diversion of Amu-Darya and Syr-Darya rivers for irrigation, various types of salts have precipitated on its former bed. Because most of these salts are sub-jest to wind erosion, the exposed bed of the Aral has become the major source of salt and dust storms in the region. Salt in the atmosphere being condensation nuclei have an impact on world climate and thus the problem becomes of Worland European concern. The objective of the project is to investigate the causes of disastrous desertification in the Aral Sea Region aiming to elaborate recommendations for the most effective remedial actions to be taken to combat desertification. The project methodology includes a) monitoring of the land, river and sea parameters being considered as key indicators of desertification and to contribute towards establishing a data information system b) modelling development to obtain an mathematical tool to understand Aral desertification process and to set upon environmental management of this basin.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Towards recycling friendly adhesive products for the paper chain (EURO-STICKIES)', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

In co-operation with the participating institutes (PTS, CTP and PIRA) a classification system has been elaborated to assess the recycle-friendliness of the adhesives. Based on the testing of selected adhesives (commercial products - typical representatives of their grade classes) for their sticky potential both in laboratory and pilot tests, basic requirements on the behaviour of adhesives in paper recycling operations were formulated.For adhesives to be recycling-friendly they should meet the following criteria:- high shear resistance of the adhesive film in the pulping process to ensure minimal fragmentation;- completely separable by screening (cleaning and flotation);- non-redispersible (no generation of microstickies and secondary stickies).Based on these results the participating adhesive producers developed new adhesives or modified some of their products with a view to enhancing the separability of adhesives in recovered paper treatment plants. The types of adhesives produced and studied were weighted to reflect the composi-tion of the Consortium. Compared to packaging and bookbinding adhesives, priority was given to pressure sensitive adhesives.The newly designed adhesives coming within the product categories of pressure sensitive adhesives and packaging adhesives (based on polyvinyl acetate dispersions) were compared with commonly used commercial products in terms of their recyclability. This comparison indicates that targeted product development in the adhesives area has in fact substantially reduced the disturbing potential of the adhesives during recovered paper treatment and in paper production processes. This may be concluded from both lab-scale tests and in near-practical pilot tests. Additionally, both adhesive sup-pliers and paper converters have evalua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Design-based Data-Driven Decision-support Tools: Producing Improved Cancer Outcomes Through User-Centred Research' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Patients with cancer often have to make complex decisions about treatment, with the options varying in risk profiles and effects on survival and quality of life. Data-driven decision-support tools (DSTs) have the potential to empower patients, support personalized care, improve health outcomes, and promote health equity (optimal decisions also for underserved groups). However, DSTs currently seldom consider quality of life or individual preferences, and their use in clinical practice remains limited.To address these challenges, the 4D PICTURE consortium will further develop a promising methodology, MetroMapping, to redesign care paths that include novel DSTs. We will better predict treatment outcomes by developing innovative algorithms and incorporating patient experiences, values and preferences, using AI-based models. In co-creation with patients and other stakeholders, we will develop data-driven DSTs for patients with breast cancer, prostate cancer and melanoma. We will evaluate these DSTs as part of MetroMapping as well as stand-alone, to ensure their sustainability as well as addressing social and ethical issues. We will explore the generalizability of MetroMapping and the DSTs to other types of cancer and across other EU member states.Improved care paths integrating comprehensive DSTs will empower patients, their significant others and health care providers in decision making, and strengthen care at the system level by improving resilience and efficiency. Whereas the 4D PICTURE consortium includes leaders in modelling, AI, decision making, citizen science, service design, ethics, risk communication, and policy making, this project will impact clinical practice and science across Europe and beyond.


**Keywords:** Shared decision making; Service design; Citizen sc