RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MOLECULAR MECHANISMS OF AUTOPHAGY REGULATION IN TUBERCULOSIS' to be submitted under Seventh Framework.

assistant: **Abstract**

Mycobacterium tuberculosis (M.tb), etiologic agent of tuberculosis (TB), is still the leading cause of mortality by single bacterial infection worldwide. Annually, these air-borne bacilli kill almost 2 million people around the globe. M.tb is an extremely successful pathogen that have developed several strategies to neutralize the host immune defenses. One of significance is the block of phagosome maturation which results in survival and replication of M.tb inside macrophages. Autophagy is a cellular lysosomal degradative process which plays a fundamental role in immune responses to M.tb infection. Indeed, multiple reports show that extracellular inducers of autophagy promote phagosome maturation and killing of M.tb by macrophages. Furthermore, autophagy enhances BCG vaccine efficiency and antigen presentation. Although, M.tb succumbs to induced-autophagy, a recent study indicates that virulent M.tb can also modulate basal autophagy to survive intracellularly. Despite important progresses made in the research field of autophagy and mycobacterial infection, how M.tb regulates autophagy and its role in virulence remains largely unknown. To gain further insights into M.tb-autophagy interplay, we propose to decipherer the molecular mechanisms involved in autophagy regulation by M.tb using original, interdisciplinary and complementary approaches. We will (1) examine the correlation between virulence, pathogenicity of mycobacteria and autophagy modulation in human macrophages; (2) determine autophagy signaling pathways regulated by M.tb; (3) identify new M.tb factors that modulate autophagy. This project proposal will expand our understanding of the intricate relationship between M.tb and autophagy and its role in virulence which should help in the future design of innovative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Using an organoid model to understand epithelial immunity in IBD' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

As the first line of defense against intestinal pathogens, gut epithelial cells are an essential part of the immune system. They may play an important role in immune-mediated diseases such as Inflammatory Bowel Disease (IBD). IBD is a group of disorders characterized by chronic inflammation of the gastrointestinal tract. IBD prevalence is high in Western countries (0.3% in 2018) and it is rising in newly industrialized countries.A prevailing model is that the interplay of two factors may cause IBD. First, a genetic predisposition weakens the gut immune system and causes high susceptibility to bacterial infection. Second, pathogenic bacteria infect the gut and trigger chronic inflammation.It is still unclear how the gut immune system may fail to repress bacterial infection in IBD. Historically, most studies have been focusing on immune cells of the hematopoietic lineage, such as macrophages and lymphocytes. However, the role of gut epithelial cells in controlling gut microbes is now gaining increasing attention. In this project, I propose to use organoids composed of differentiated intestinal cells to study how the intestinal epithelium responds to bacterial infection in the context of IBD.I will establish an in vitro model of IBD based on human small intestine organoids. I will infect the organoids with the bacterium Adherent-Invasive Escherichia coli (AIEC) and study how the differentiated intestinal cells respond to AIEC invasion. I will both test the relevance of a well-known IBD genetic predisposition (the mutation 1007fs in Nucleotide-binding oligomerization domain 2 (Nod2)) and explore novel mechanisms underlying the immune response of gut epithelial cells using RNAseq and CRISPR base editing. My project will dissect the molecular mechanisms of IBD. In addition, i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Perception for recognition and action' (PRA) targeting Fifth Framework.

assistant: **Abstract**

To understand the brain processes that lead to behavior will be one of the greatest scientific challenges of the new millennium. The aim of the present research proposal is to examine the basic mechanisms of visual perception for the purposes of scene recognition and action planning. We propose to address this aim along three complementary themes of research. First, we shall study the perceptual attributes for recognition by looking at luminance and chromatic cues for scenes, the attention to diagnostic information, and the binding problem of the different visual attributes. Second, we shall focus on the perceptual attributes for action by studying the visual segmentation problem, which three- dimensional cues are being used for action, and the underlying cerebral pathways for these visuo-motor tasks. Finally, we shall study the interaction between recognition and action by focusing on the imitation of human movement, the eye movements used during scene exploration, and the high-level representations for the planning of actions. These three research themes will involve three more specific research projects and each research project will correspond to two or three experiments. Each research project will be investigated with a variety of experimental paradigms borrowed from psychology, motor control and brain imaging. For instance, the perception of motion transparency will be addressed both from a psychophysical point of view to determine the efficiency of human observers in this task, but also with the help of fMRI studies to reveal the brain structures involved in this task. Our ultimate goal is to increase our understanding of the perception for recognition and action through active collaboration and shared expertise of eight leading laboratories in Europe in these fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Conserving Forests through Indigenous Heritage: The UNESCO World Heritage Cultural Landscape, Alternative Sovereignty and Semai Life Projects in Peninsular Malaysia’s Last Surviving Rainforests'.

assistant: **Concept**

Seraaq, the project acronym, means ‘forest’ in the Indigenous Semai language, connoting the sentience and sacredness of forests, and the moral calling to forest stewardship. The project highlights the importance of Semai (agri)cultural heritage in forest conservation, and the need for a blueprint to achieve, at minimum, alternative sovereignty: could the UNESCO World Heritage Cultural Landscape serve as a tool of empowerment for the minority Semai people of Peninsular Malaysia? SERAAQ’s originality lies in linking cultural heritage protection to securing Indigenous rights to forests and resources, and by identifying ways to support Indigenous forest livelihoods as a purposeful community development option within and in spite of prohibitory state structures. SERAAQ also demonstrates that Indigenous heritage resources are real, functioning parts of Indigenous social-ecological systems rather than free-standing, unidimensional cultural heritage elements. I will assess the potentialities of the WHCL mechanism, and gather documentation of contemporary Semai forest reliance and ‘living’ heritage, by using political economy analyses and field-based survey, PhotoVoice and scenarios planning approaches. This will produce quantifiable, evidence-based data, to persuade and effect change at the decision-making/governance levels. This evidence will take into account Semai articulations of their own self-determined ‘life projects’ or forest-based futures, ideas of forest protection and community empowerment outcomes, e.g, inclusion in forest governance processes; public recognition of the Semai homeland; and legal rights to their customary forestland. An MSCA fellowship will help me innovate my oral tradition research background, to work expertly on political/socioeconomic topics in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Minor ROot and Tuber crops fostering AgrobiodiversiTy and Ecosystem Services' in the context of a Horizon Europe call.

assistant: **Objectives**

ROTATES aims to sustainably enhance agrobiodiversity and ecosystem services by introducing and promoting minor starchy root and tuber crops (MRT) sweet potato, yams, cassava and taro, considered minor crops and currently underutilized in Europe, in both conventional and organic farming systems. These crops have substantial growth potential in temperate regions to meet the increasing demand in Europe, which has tripled over the last decade. The inclusion of MRT crops will complement the cohort of minor crops introduced into European agrosystems by the previously funded projects. Employing a multidisciplinary and multi-actor approach, ROTATES will (i) identify levers for MRT crop adoption along the value chain, through a comprehensive diagnosis of constraints and opportunities for MRT crop adoption, agronomic practices to inform farm typology analysis, genetic material assessment, and disease pressure evaluation, (ii) deploy MRT crops by developing agroecological management practices, including crop rotation and intercropping, to leverage the benefits on provisioning and regulating ecosystem services, establishing breeding hubs to deliver varieties adapted to the agroecological systems, and creating a clean seed system relying on a policy framework for phytosanitary certification to support sustainable production and material exchange, (iii) unlock the value of MRT crops by establishing sustainable and innovative healthy and traditional food and feed transformation processes, integrating livestock to recycle unused plant by-products and provide crop amendments - gluten-low-to-free pasta, bread, and plant-based ice cream and feed for ruminants and monogastrics- (iv) promote adoption along the value chain, targeting primarily farmers and growers, through marketing avenues a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Peri-urban mangroves forests as filters and potential phytoremediators of domestic sewage in East Africa' (PUMPSEA), addressing dissemination and exploitation.

assistant: **Impact**

ABSTRACT: Peri-urban coastal areas of the developing world receive extensive amounts of untreated sewage, which is typically discharged into creeks lined by mangrove forests. Mangroves in all probability filter this discharged wastewater, thereby limiti ng coastal sewage pollution. This project aims to demonstrate this ecosystem service and to examine its ecological and socio-economical effects. It will develop the technology for using constructed mangrove wetlands for secondary treatment of domestic se wage water. It will examine the feasibility of strategic reforestation and conservation" in sewage hotspot areas, to encourage natural mangrove filtration of discharged wastewater. It will develop an implementation plan for the exploitation of the devel oped technology and know-how, based on analysis of governance, policy, cost and financing options. The work will take place in peri-urban mangrove areas of Maputo (Mozambique), Dar es Salaam (Tanzania) and Mombasa (Kenya). It will include: socio-economy, condition mapping, biogeochemistry, ecology, modelling, controlled experimentation and experimental optimisation of a trial wetland used for secondary treatment of sewage. Governance analysis and implementation planing will focus on Dar es Salaam, but have reference to Maputo and Mombasa. PUMPSEA addresses INCO research objectives A.2.2 (primarily) and A.2.1 (secondarily), by valuation of coastal ecosystem services, and by supporting policy and management analysis into mitigating the degradation of co astal zones in peri-urban areas. Using constructed mangrove wetlands for sewage treatment could be an innovative solution that complies with the social, economic and environmental contexts of developing countries. Strategic mangrove conservation and refo restation in sewage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CarbOn Neutral cluSters through Electricity-based iNnovations in Capture, Utilisation and Storage' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The EU has set a clear target to curb climate change: a climate neutral industry by 2050. For several crucial EU industries, this means that the CO2 they emit needs to be captured, utilised and/or stored. ConsenCUS aims to provide an industrial roadmap to a net-zero carbon future through “Carbon neutral clusters by electricity-based innovations in Capture, Utilisation and Storage”. We will demonstrate this concept by integrating a demonstration unit at major cement, magnesia and oil refining installations.The project presents technological innovations in the 3 main components of CCUS: (1) carbon capture based on alkali absorption, coupled to a novel electrodialysis cell (100 kg CO2/h), (2) conversion of CO2 to formate and formic acid for the current market, as well as emerging markets and (3) safe cyclic loading of CO2 into salt formations and aquifers for storage. The capture and conversion routes are unique in taking only electricity and water as consumables, while providing energy- and cost-efficiency beyond the current industrial standard (targets: TRL 6-7, 1.4 GJ and €34 per tonne CO2). Life cycle analysis and techno-economic evaluations will address how the innovations can be exploited, optimising environmental benefits while providing sound business cases for the three sectors participating and beyond.ConsenCUS also designs so-called CO2 clusters and networks in NW and SE Europe, around our demonstration sites. Our partners are spread across the CO2 value chain and will optimise such clusters based on an interconnected network of emitters fitted with (our) carbon capture and utilisation technology, other CO2 end users and geological storage. Joint infrastructure and operation will drive cost down and encourage collaboration. Importantly, we will create narratives
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Support Action for a Transport ICT European large scale action' in the context of a Seventh Framework call.

assistant: **Objectives**

The SATIE support action will prepare the way for the successful launch of a programme of European large scale actions (elsas") to accelerate the deployment of ICT for sustainable mobility and transport. It will provide assistance to programme managers and potential participants before the programme begins, and will explore the key elements of an elsa before issuing guidelines for the design, construction and operation of an elsa in the form of an "Elsa Handbook". SATIE will:1.\telaborate the concept, procedures and added value of a large scale action2.\tdisseminate and raise the awareness with regard to the possibilities of a Transport-ICT elsa with all stakeholders throughout Europe3.\tmap existing initiatives and possible future initiatives which would fit into an elsa approach.The essential commitment of the stakeholders and service champions is achieved by an iterative process of consultation aiming towards the efficient intergration of European, national, regional and local policies, innovative procurement practices, European funding instruments, European and national innovation platforms, exploitation of R&D and the objectives of the public and private stakeholders within the value networks of ICT for mobility and transport. The iterative process aims to specify the optimum elsa with regard to the added value to European innovation and economy as well as the European transport system in view of its sustainability in terms of environment, safety, and efficiency. Building on this the Support Action will be able to provide the Commission with input for evaluating the concept of a large scale action and launching a European programme."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Application of multi-analyse sensor technology in biotechnological, industrial and environmental process monitoring'.

assistant: **Concept**

A whole new generation of optical sensors which allows the precise measurement of key compounds in liquids are still limited in their use to very small niches in the medical field (blood gas e.g.).The new generation of optical sensors are based on luminescence decay time of phosphorescent materials, which have the advantage of being non-invasive and far more reliable than conventional optical sensors due to their interdependence of light intensity, thickness of sensing layer and the optical properties of the analyte.The main objective is transfer and adaptation of optical based sensor technology from point of care medico-technical applications to industrial and environmental monitoring and biotechnology applications. This raises severe demands on price and performance.The objective is to be achieved through development of a miniaturised industrial multi-analytic sensor capable of measuring several parameters simultaneously (e.g. oxygen, carbon dioxide, salinity, pH and temperature).The goal is to develop a small sensor unit with a diameter of less than 20mm which is ten-times cheaper compared to the combined price of the sensors capable of measuring the same parameters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Efficient Systems and Propulsion for Small Aircraft' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The ESPOSA project will develop and integrate novel design and manufacture technologies for a range of small gas turbine engines up to approx. 1000 kW to provide aircraft manufacturers with better choice of modern propulsion units. It will also deal with engine related systems which contribute to the overall propulsion unit efficiency, safety and pilot workload reduction. Through the newly developed design tools and methodologies for the engine/aircraft integration the project will also contribute to the improved readiness for new turbine engines installation into aircraft. New technologies and knowledge gained through the ESPOSA project will provide European general aviation industry with substantially improved ability to develop and use affordable and environmentally acceptable propulsion units and reliable aircraft systems minimizing operating costs, while increasing the level of safety.  The new engine systems and engine technologies gained from ESPOSA should deliver 10-14% reduction in direct operating costs (DOC) and reduce significantly the pilot workload. The ESPOSA project is oriented on turbine engine technologies tailored for a small aircraft up to 19 seats (under CS-23/FAR23) operated on the scheduled and non-scheduled flights. The research work comprises performance improvements of key engine components, their improved manufacture in terms of costs and quality.  New engine component technologies will be backed by novel modern electronic engine control based on COTS, pioneering the engine health monitoring for small engines and providing new more electric solutions for fuel and propeller control systems. Project activities will include extensive validation on the test rigs. The most appropriate technologies according to value/cost benefit will be selected an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Flexible Behaviors for Humanoid Robots and Digital Humans'.

assistant: **Innovation**

The main application considered in this research and training project is walking humanoid robots, a second application being digital humans. The core scientific and technological results should however have a strong impact on other fields such as industrial manipulator robots.  Indeed, the main objective of this research and training project is to enhance the algorithms and control laws of existing humanoid robots in order to obtain a walking behavior versatile and safe enough to be integrated into higher level tasks such as manipulation, vision, tele-operation, interaction with humans, which all require a strong capacity to face unforeseen events in an efficient way. But the objective is to solve this problem with a solution general enough to be applied also to the case of manipulator robots.