RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mechanisms of memory loss and Neuro-degeneration caused by loss of Presenilin Function in Alzheimer's disease' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

In recent years, and as a result of extended life expectancy, the number of people affected by Alzheimer’s disease (AD), a neurodegenerative disorder that slowly and progressively impairs memory and intellectual abilities, has dramatically increased . AD affects usually people of advanced ages and its origin in most cases is unknown.However, the majority of pre-senile AD cases (< 65 years of age), are caused by inherited familial mutations in the Presenilin genes. Presenilins are the catalytic components of g-secretase, a multiprotein complex that generates the b-amyloid (Ab) peptides, which aggregates and accumulate into amyloid plaques in the AD brain. The accumulation and deposition of Ab is thought to be a key event in the pathogenesis of AD.The toxic effects of Ab on cultured neurons and transgenic mice have been extensively studied. However, the molecular mechanisms by which mutant presenilins cause memory loss and neurodegeneration are largely unknown. To study the biological function of presenilins in the adult brain we generated recently neuronal-specific presenilin conditional knockout mice.We found that presenilin inactivation in the adult mouse brain causes synaptic dysfunction and neurodegeneration by altering CREB/CBP-mediated gene expression. This raises the possibility that loss of presenilin function may cause memory deficits and neurodegeneration in AD. In this project, we will investigate the molecular mechanisms, by which presenilins regulate CREB-dependent signalling, which is essential for neuronal function and survival.Based on the analysis of the mouse genome, we will examine how normal and mutant presenilins regulate CREB/CBP signalling. These studies will integrate genomic approaches into our knowledge of human diseases and will facilitate the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'In control of exciton and charge dynamics in molecular crystals' under Horizon 2020.

assistant: **Concept**

The aim of the work proposed here is to achieve control over charge and excited state dynamics in organic crystalline materials and in this way to come to solid state materials with explicit built-in functionality. The charge and excited state dynamics do not only depend on the properties of individual molecules but are to a large extent determined by the interactions between multiple molecules. By careful engineering of the properties of individual molecules and of the way they aggregate in the solid crystalline state it is in principle possible to design materials that exhibit a specific functionality. Examples of this are materials that are optimized to give high charge carrier mobilities and high exciton diffusion coefficients. It is also possible to design more complex functionality. An example of this is singlet exciton fission, a process by which one singlet excited state transforms into a combination of two triplet states. This spin-allowed process can in principle increase the efficiency of organic solar cells by a factor 1.5. A second example is upconversion of low energy photons into higher energy photons. This is possible by combining two low-energy triplet excited states into a single singlet excited state by triplet-triplet annihilation. Finally, it is possible gain control over charge separation on the interface of two different materials to increase the charge separation efficiency in photovoltaic cells.In this work, we will explore ways to achieve control of charge and exciton dynamics in a combined effort including organic synthesis, computational chemistry and time-resolved spectroscopy and conductivity experiments. This research represents a major step forward in the understanding of the relation between molecular and solid state structure and the el
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Designing Allosteric Protein Switches by In Vivo Directed Evolution and Computational Inference' (DaVinci-Switches) under Horizon Europe.

assistant: **Objectives**

Proteins are molecular machines that drive all major functions in cells. Controlling the activity of proteins in real time via light or chemicals is a central goal in synthetic biology. The design of switchable proteins, in particular single-chain, allosteric variants, however, is a challenging engineering problem thus-far mostly addressed by trial-and-error. DaVinci-Switches takes a radically new, data-driven perspective to fundamentally advance our understanding of protein allostery and accelerate and eventually rationalize the engineering of switchable proteins by interfacing synthetic biology with machine learning. We will establish a 'design by directed evolution' approach to create switchable proteins through receptor and effector fusion followed by phage-assisted in vivo directed evolution using synthetic gene circuits for selection. We will apply this novel pipeline to a diverse set of effector proteins and monitor the evolutionary process by next-generation sequencing (Objective 1). In parallel, we will perform an in-depth computational analysis of domain insertions within the natural protein repertoire. The combined, rich datasets will be used to train machine learning models to infer sequence patterns predictive of domain insertion tolerance and allosteric coupling between receptor-effector pairs (Objective 2). Finally, we will employ this unique model to design light- and drug-inducible variants of the Yamanaka cell reprogramming factors. These will provide the foundation of an Adeno-associated virus-based platform for cyclic, partial in vivo reprogramming of somatic cells with enormous potential for regenerative medicine, which will be evaluated in a murine model of drug-induced liver injury (Objective 3). DaVinci-Switches harnesses our key competences in p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'FI-GLOBAL: Building and supporting a global open community of FIWARE innovators and users' in the context of a Horizon 2020 call.

assistant: **Objectives**

Through the FIWARE Mundus activities, mostly performed in the FI-LINKS project, countries from all over the world have already started to mobilize innovators and users around new FIWARE ecosystems. FIWARE is currently stepping out from experimentation into commercialisation. The technology must be adopted at global level in order to allow European FIWARE stakeholders to expand their reach worldwide.The first main objective of FI-GLOBAL is to underpin a FIWARE global community, by increasing the number of FIWARE ecosystems all around the world. FI-GLOBAL will identify and engage multiple stakeholders, who will help bootstrapping innovation ecosystems around FIWARE, provide support to startups, enhance the open platform with additional FIWARE components, and deploy new FIWARE nodes. FI-GLOBAL facilitates the set-up of a worldwide recognized FIWARE Master Course to educate future students and establish international cooperation via a FIWARE Education Community.The second main objective is to incentivise the take-up of the FIWARE platform and facilitate the means for an effective cooperation among innovators and users from the global community. FI-GLOBAL will mobilize a truly global marketplace of FIWARE applications that will stimulate new solutions and business ideas, and incentivize innovators and users to discover the platform and adopt the technology. This will be done by providing tools that support the cooperation among the global ecosystems to implement new ideas/services and match particular needs that may have been already tackled by FIWARE solutions; and launching a FIWARE Global Piloting Programme to encourage the improvement and replicability of FIWARE solutions at global scale.Reaching these objectives will contribute to make FIWARE the “de facto” reference in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integration of Solar technologies into Buildings in Mediterranean Communities' (2002-2006).

assistant: **Concept**

SOLAR-BUILD will contribute significantly to uptake of solar technologies to meet cooling, electricity & heat needs in buildings in Mediterranean communities, via new links & information exchange between relevant professional fields & via transfer & adaptation of experience from EU to non Mediterranean countries. Partners are leading networks of sustainable energy professionals & architects within the region, led by CRES who has long-term in-depth experience of research, development & application of solar technologies. Partners will engage with extensive market actors & stakeholders including: architects, building engineers, solar technology manufacturers / retailers etc, local authorities / municipalities, central government departments.Specific work objectives are:- To analyse local conditions, current status, future market opportunities & threats.- To convene working groups comprising relevant professions to deliver analyses & reports on above issues.- To hold two workshops (Morocco & Egypt) to present & discuss the market analyses results & identify follow-on actions with market actors & stakeholders.- To collate conclusions & recommendations from above tasks into one e-guide for building-integrated solar technologies in Mediterranean.- To disseminate findings including targeted emailing to partner's extensive networks & to make all information & results available via project web site.This will result in increased awareness among actors, concerning the potential of applying Mediterranean-wide & locally adopted solar energy solutions in community buildings. Actors will be equipped with new knowledge & contacts to take forward with research, development & implementation actions. The project offers an important contribution to long-term socio-economic development by pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Collaborative medical image analysis on the Grid' (CMIAG).

assistant: **Innovation**

The aim of CMIAG is to establish a unique, world-class multi- and interdisciplinary research-training programme in advanced medical image analysis. CMIAG will bring together a rich mix of specialists in Computer Science, Mathematics, Magnetic Resonance, Neuroimaging/Neuroscience, Clinical Neurology, and Psychology, to provide a high quality training programme in integrative medical image analysis and high performance computation.CMIAG will target the crucial areas of healthcare, assisting medical image analysis and diagnosis of brain diseases, tumour, cancer, and the aging process, by machine interpretation of Magnetic Resonance (MR) scans and other types of medical images and data. CMIAG will benefit from high performance computing paradigms such as e-Science/Grid, which has the potential to revolutionise medical imaging research and disease diagnosis by allowing a unified approach to tackle complex tasks.The ultimate objective of CMIAG is to address the problem of EU research fragmentation in the vital area of eHealth by bringing together key researchers from various domains of expertise to create a dynamic, critical mass of medical imaging specialists, for medical data acquisition, processing, analysis, and disease diagnosis via collaborative research in the Grid environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Formation of Degradable Photoantimicrobial Materials via Light Induced 3D Printing' under Horizon Europe.

assistant: **Concept**

It has been an ongoing requirement for humankind to access useful objects or to provide the missing part of damaged products. 3D printing (3DP) has become popular by completing these deficiencies in a very short time and low cost. Its many derivatives are available, however, it is a necessity to choose suitable modules and inks that fulfill the needs of in todays world. Energy consumption of the world is increasing rapidly and this concept should be carefully considered in every step to be taken from social life to industrial life. Thus, light-induced 3D printing (L3DP) stands out with its features such as using clean energy source, high resolution and accuracy. Nonetheless, substantial effort is necessary to identify and put into action suitable photochemical interactions for this objective. Significantly, the selection of these interactions must be carried out carefully since the resulting materials should meet other contemporary demands; such as Recyclability. Dibenzazapine (DBA) and triazolinedione (TDA) are important molecules capable of giving light-induced reactions. Their reversible reactions with light and buffer solutions offer them the advantage to form degradable products and they can be promising candidates for L3DP. On the other hand, following the impact of COVID-19, the medical industry has reached a pivotal moment where the significance of antimicrobial materials has been better understood. However, the developed materials cannot keep up with the resistance rate of microbes and different combat strategies are necessity to cope with them. Antimicrobial photodynamic therapy (aPDT) is method which is utilized the interaction between photosensitizer (PS) and light, and it can be strong alternative for this purpose. In this context; zinc phthalocyanine as ph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Archimedes 2001: 'phd at the london school of economics'' (1998-2002).

assistant: **Innovation**

In a future book on international economic history, the nineties will probably be called the decade of cuaency crises." The series of cases of the European Monetary System in 1992-1993, the Mexican crisis in 1995, the Asian crises and the Czech koruna turbulence in 1997, the Russian and Brazilian crises in 1998 all prove that countries do not have the appropriate monetary system for the extremely fast capital movements in the World. The crisis of the Exchange Rate Mechanism in Europe destroyed the illusion that only the countries with serious macroeconomic imbalances have to face the ask of speculative attacks. It became clear that macroeconomic theory did not know enough about the mechanisms which may trigger a currency crisis. Since then, a lot of work has been done in this field. A group of new theories found that mechanisms based on the expectations of the speculators could lead to self- fulfilling currency crises. Other models showed that simple changes in the assumptions about the informational structure of the speculators could radically change the outcome. In this paper, I argue that an important element of speculative attacks missing from the currency crisis literature. This element is the rational herding behavior of the speculators. I build a model that shows that herding effects may cause currency crises even in economies with sound macroeconomic indicators. I argue that the fixed exchange rate constrains the information revealing capability of the exchange rate and it may cause a speculative attack. It may happen that all the speculators join the attacking herd, believing that others have private intormation showing that the attack will be profitable, although the majority of them have private intonation showing the contrary. I prove that this model can exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Analysis of TOR complex 2 in Drosophila' (2002-2006).

assistant: **Innovation**

The insulin signalling pathway is highly conserved throughout animal evolution and it regulates multiple biological processes including metabolism, tissue growth and longevity.Due to the high conservation of this pathway, genetic model organisms, such as the fruit fly Drosophila melanogaster, have been powerful in characterizing new regulators of insulin signalling and elucidating their biological functions.This study is aimed to study the in vivo role of a potential modulator of the insulin-signalling pathway, TOR (target of rapamycin) complex 2, in Drosophila. The TOR kinase is present in two highly conserved complexes.While the role of TOR complex 1 in the coordination of tissue growth and nutrient sensing is well established, the function of TOR complex 2 is poorly understood. In cell culture studies, TOR complex 2 has been shown to regulate actin cytoskeleton as well as to phosphorylate AKT/PKB, an effector kinase in insulin signalling pathway.However, the in vivo role of TOR complex 2 in multicellular organisms has not been addressed. To this end, I have generated flies mutant for rictor, a gene essential for the function of TOR complex 2. Analysis of the rictor mutant flies should provide novel and significant insights into the physiological role of TOR complex 2.As the function of the insulin signalling pathway is disturbed in diseases such as diabetes and cancer, the results of this study are likely to have ramifications to human health.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'PI3K in immunity and inflammation'.

assistant: **Concept**

Acronym: BOOSTINAbstract:This research proposal focuses on the interplay between two key groups of signalling molecules in immune signalling.The first are the phosphoinositide 3 kinases, (PI3Ks) which produce intracellular lipids second messengers. Deregulated PI3K signalling has been implicated in cancer, inflammation and autoimmunity, and PI3Ks are new targets for therapeutic intervention in human disease. Mammals have multiple isoforms of PI3K, the individual roles of which are largely unknown.The second group are the Toll receptor (TLR) family of proteins, which are amongst the most ancient and evolutionarily conserved pathogen recognition receptor families that serve as the earliest surveillance system for infections.Several mechanisms negatively control TLR signalling pathways, thereby preventing over-activation of inflammatory responses. PI3K signalling is one of these systems. However, the interaction between the TLR and PI3K signalling systems has not been investigated in any detail, and the impact of PI3K isoform-selective signalling in TLR-controlled innate and adaptive immunity has not been delineated.This proposal aims to investigate the isoform-specific roles of a subset of PI3Ks in TLR signalling in the context of antimicrobial and anti-tumour immunity, using dendritic cells (DC) as the key model. DCs are the chief cell populations, which recognize pathogen-derived molecular signatures through TLRs and orchestrate the ensuing adaptive immune responses. For these studies, I will have unique access to newly developed and truly unique mouse models and pharmacological tools for isoform-specific PI3K inactivation.Other than widening my scientific horizon and allowing me to establish international contacts, this work will prepare me to secure a prospective inde