RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Nacht der Wissenschaft in der Kiel Region 2018/2019' in the context of a Horizon 2020 call.

assistant: **Objectives**

Following the resounding success of the first NIGHTs in 2016/17, SCIENCE4FUTURE will once again in 2018 and 2019 bring together all of Kiel Region’s 14 research organisations comprising all academic disciplines to showcase their scientists and work to the public. With 5 participating cities (Kiel, Rendsburg, Eckernförde, Plön and Preetz) and over 30 supporting institutions from the public, private and non-governmental sector, it will be the largest public event dedicated to science in Northern Germany. A multifaceted awareness campaign with live broadcasts during the NIGHTs will reach 80% of the households. More than 100 activities per NIGHT will give the public a chance to personally talk, work and play with scientists thus breaking down stereotypes. SCIENCE4FUTURE will focus on the general themes of identity (to celebrate Europe’s Cultural Heritage), mobility, diversity and Europe, which are ideally suited to showcase the whole spectrum of social, environmental and economic benefits that our researchers achieve every day. Free shuttles will allow visitors (minimum 12,000 expected visitors per NIGHT) to see the broad range of local, national and European research projects in our region. With a careful choice of venues (eg malls, cinemas, night clubs), the involvement of schools, a targeted publicity campaign and a fun-filled programme, the two NIGHTs will attract particularly children and young People, including those usually less interested in academia. Researchers will demonstrate simple “take-home” experiments to teachers, nursery staff and parents to ensure that the interest for research sparked during the event is kept alive beyond the NIGHT. Moreover academic support services (international, student admissions and diversity offices) will offer advice on career op
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploring Duality for Future Data-driven Modelling' under Horizon 2020.

assistant: **Concept**

Future data-driven modelling is increasingly challenging for many systems due to higher complexity levels, such as in energy systems, environmental and climate modelling, traffic and transport, industrial processes, health, safety, and others. This requires powerful concepts and frameworks that enable the design of high quality predictive models. In this proposal E-DUALITY we will explore and engineer the potential of duality principles for future data-driven modelling. An existing example illustrating the important role of duality in this context is support vector machines, which possess primal and dual model representations, in terms of feature maps and kernels, respectively. Within this project, besides using existing notions of duality that are relevant for data-driven modelling (e.g. Lagrange duality, Legendre-Fenchel duality, Monge-Kantorovich duality), we will also explore new ones. Duality principles will be employed for obtaining a generically applicable framework with unifying insights, handling different system complexity levels, optimal model representations and designing efficient algorithms. This will require taking an integrative approach across different research fields. The new framework should be able to include e.g. multi-view and multiple function learning, multiplex and multilayer networks, tensor models, multi-scale and deep architectures as particular instances and to combine several of such characteristics, in addition to simple basic schemes. It will include both parametric and kernel-based approaches for tasks as regression, classification, clustering, dimensionality reduction, outlier detection and dynamical systems modelling. Higher risk elements are the search for new standard forms in modelling systems with different complexity levels, matc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A European Cancer Image Platform Linked to Biological and Health Data for Next-Generation Artificial Intelligence and Precision Medicine in Oncology', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The goal of EuCanImage is to build a highly secure, federated and large-scale European cancer imaging platform, with capabilities that will greatly enhance the potential of artificial intelligence (AI) in oncology. Firstly, the EuCanImage platform will be populated with a completely new data resource totaling over 25,000 single subjects, which will allow to investigate unmet clinical needs like never before, such as for the detection of small liver lesions and metastases of colorectal cancer, or for estimating molecular subtypes of breast tumours and pathological complete response. Secondly, the cancer imaging platform, built by leveraging the well-established Euro-Bioimaging infrastructure, will be cross-linked to biological and health repositories through the European Genome-phenome Archive, allowing to develop multi-scale AI solutions that integrate organ-level, molecular and other clinical predictors into dense patient-specific cancer fingerprints. To deliver this platform, the consortium will build upon several key European initiatives in data sharing for personalised medicine research, including EUCANCAn (cancer genomics and health data sharing), euCanSHare (cardiac imaging and omics data sharing) and EUCAN-Connect (federated data analytics). Furthermore, to foster international cooperation and leverage existing success stories, the consortium comprises the coordinators of The Cancer Imaging Archive (TCIA), the US cancer imaging repository funded by the National Cancer Institute. This will allow EuCanImage to leverage a unique 10-year long experience in cancer imaging storage, anonymisation, curation and management. Finally, a close collaboration between world renown clinical, radiomics, AI and legal experts within the consortium and beyond will establish well-nee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Integrated needle-free injection and sensing using opto-microfluidics' in the context of a Horizon Europe call.

assistant: **Objectives**

Needle-based injections have revolutionised healthcare by providing an efficient delivery method for medications, such as vaccines. However, there are significant drawbacks associated with using needles on a societal, environmental, and technological level. Needle phobia and infection risks can significantly impact patient compliance and safety with medical treatments, while millions of used needles contaminate the environment every day. Lastly, the effectiveness of certain drugs increases when injected intradermally, but targeting the dermis is challenging.With iSENS, we want to revolutionise the experience of people who receive and perform frequent injections. To this end, we are developing and commercialising a portable and needle-free injector called BoldJet. Our technological breakthrough is threefold:Needle-Free Injection Breakthrough: We introduce an innovative needle-free injection technology, globally pioneering the use of thermocavitation microjets. Our system excels in the precise and consistent delivery of liquids into the skin's superficial layers, surpassing current state-of-the-art methods. Smart Sensing Capability: The BoldJet device will incorporate cutting-edge sensing technology, enabling it to assess the unique properties of the patient's skin before each injection. This breakthrough allows for semi-automatic calibration, tailoring the injection parameters to the specific skin type and treatment area. Real-Time Monitoring and Precision: BoldJet goes beyond conventional methods by offering real-time monitoring of injection depth and volume. This feature guarantees that each dose is administered accurately and consistently.With our triple technology platform, we will offer a safer, more effective, and minimally invasive injections that do not contamina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Unravellling the biological determinants of space use patterns in animals' (SpaceUseDrivers), addressing dissemination and exploitation.

assistant: **Impact**

Patterns of space use by animals appear to be immensely diverse. However, recent work has suggested that they can all emerge from the interplay between only four drivers: cognitive abilities, movement constraints, social behaviour, and environmental conditions. Despite the considerable implications of space use patterns for ecological processes (e.g. nutrient fluxes, disease dynamics, invasions, extinctions), we still lack a unified theory of the causal links between the observed breadth of space use patterns and their drivers. This is mainly because there is little integration between field studies of the different types of movement (e.g. territoriality, nomadism, migration), and an uncomfortable divide between mechanistic movement models and data.In this project, I will combine for the first time individual-based modelling and recent advances in statistical analysis applied on a unique portfolio of tracking data comprising three ungulate, two seabird, and one fish species. This approach will enable me to 1) develop a universal individual-based model of animal movement that can generate all existing types of space use patterns, 2) infer what biological  mechanisms and parameters are implied by the patterns observed in nature, and 3) introduce a new methodology to the movement ecology research field. I will use this new integrative framework to specifically investigate four hypotheses on the drivers of site fidelity (residency), spatial segregation, migration and aggregation.This project will not only greatly advance our understanding of the determinants of space use patterns, but will also be a crucial precursor to predicting how complex natural and anthropogenic environmental changes may impact animal populations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Hierarchical and Adaptive smaRt COmponents for precision production systems application' (HARCO) targeting Seventh Framework.

assistant: **Abstract**

The primary goal of HARCO project is to achieve cost-effective structural solutions consisting of a new class of Smart Components (belonging to machine tools applications) based on plug-and-produce “Modular Adaptronic devices” which integrate smart and multifunctional actuators/sensors capable of performing a wide array of multiple functions, ranging from high and adaptable damping and stiffness characteristics to more demanding new requirements, such as active structural measurement and control function to achieve extremely high dynamic/thermal stability required in fast and precision machining. The approach followed by HARCO is the hierarchical combination of lower level units (named here “Functional Bricks” to generate higher level modules (named here “Adaptronic Modules”) which in turn are used and integrated into machine parts to generate the master component (named “Adaptive Smart Components”). Then the basic idea is to design and develop a sort of “fractal” and “hierarchical” elements (not only mechanical hardware but also controllers and software) that can be easily put together (plugged-in) to form/produce higher level modules/components (modules that build modules!) for active vibration control, thermal compensation and adaptive fixturing in precision machine tools applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Crystallisation towards efficient and sustainable biomanufacturing' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Downstream processing (DSP) of biopharmaceuticals is dominated by chromatographic steps which suffer from low throughput, poor scalability and elevated energy consumption, as well as high equipment and materials costs. To this is added the low stability and high degradability of liquid formulations. The training program ""Crystallisation towards efficient and sustainable biomanufacturing"" (PROCRYSTAL) vision is that of crystallisation as a simple, sustainable, cost-efficient and scalable alternative to current DSP techniques and liquid formulations, once it allows to separate, purify and stabilise in a single step. Nevertheless, integrated training to exploit biocrystallisation full potential is currently not available, only fragmented research activities. Within this training program, 13 Doctoral candidates (DCs) are expected to go beyond current practise to respond to the near future biopharma manufacturing needs. And only possible leveraged by the expertise conveyed in this consortium on biomolecules crystallisation, biochemistry, chemical and process engineering as well as advanced modelling. The PROCRYSTAL training program for the DCs has been framed with special attention to fundamental understanding of the underlying phenomena, from the molecular scale to process scale, and advanced experimental and modelling techniques specific to crystallisation technology. The DCs will acquire a wide range of subject specific and general transferable skills, in an interdisciplinary and inter-sectoral environment and by multinational collaboration which enhances the early-career DCs long term employability and competitiveness.""


**Keywords:** Crystallisation; biomolecules; biopharmaceuticals; downstream processing; sustainability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A hyBRID (physical-diGital) multi-user Extended reality platform as a stimulus for industry uptake of interactive technologieS' (BRIDGES).

assistant: **Innovation**

BRIDGES aims to support and boost the pan-European interactive technologies industry and contribute to “bridging” the gap between interactive technologies and industry, through the development of a holistic solution for (remote and co-located) group interactions in room-scale immersive mixed reality (or eXtended Reality - XR) environments that blend the physical and virtual space. The BRIDGES solution is based on an existing Immersive DeckⓇ platform, which will be further enhanced and developed into a turn-key product with widespread applicability that may act as a stimulus for the uptake of interactive technologies by industry.BRIDGES will focus on the areas of training and informal learning, culture, and entertainment, as it is widely recognized that immersive XR is an extremely promising tool for the enhancement of the user’s experience in these areas, and an optimal medium for achieving enhanced performance, engagement, a high level of effectiveness, and the transfer of skills and knowledge into the real world. To ensure widespread uptake, we will carry out extensive and comprehensive studies to validate the proposed solution in the real world settings of two major international airports in Germany and Greece for training firefighters and first responders, and in a highly visited informal educational and cultural center/museum in Greece, for enhancing the learning and recreational experience of visitors. The extensive validation effort undertaken by BRIDGES is expected to lead to the short-term commercial deployment of the BRIDGES end-results in the specific domains addressed by the project pilots, but also to provide replicability recommendations and scale-up guidelines for deploying the resulting XR platform in other industrial and entertainment domains, in the lo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Collaborative development of renewable/thermally driven and storage-integrated cooling technologies' (CO-COOL), addressing dissemination and exploitation.

assistant: **Impact**

Cooling is the fastest-growing use of energy in buildings but is also one of the most critical blind spots in today’s energy debate. Rising demand for space cooling is putting enormous strain on electricity systems in many countries, as well as driving up emissions. Comparing to heat, power, and transport, cooling had long been under-represented in the EU energy policy until 2016 when the European Commission took the first step with the launch of its Heating and Cooling Strategy. The strategy identifies actions of ‘increasing the share of renewables’ and ‘reuse of energy waste from industry’ as two key areas for decarbonizing cooling to meet the EU’s climate goals by 2050. Accordingly, the targets are only achievable with fast development and deployment of new efficient and effective cooling technologies driven by either ‘renewable electricity/heat’ or waste heat. This CO-COOL RISE project assembles an international, interdisciplinary consortium from 12 research institutions and 5 industrial companies to collectively accelerate the cooling technology development and deployment, with complementary expertise/skills including composite solids, phase change materials (PCMs), complex fluids, process intensification (heat and mass transfer), cold thermal storage, refrigeration systems, as well as techno-economic analysis (TEA) and life cycle assessment (LCA), marketing analysis, and entrepreneurship skills. Based on the innovation of composite solids (sorbents/PCMs) and fluids (PCMs and hydrate slurries) as well as related components and systems, the project aims to develop renewable/recoverable energy driven, storage-integrated cooling technologies which could offer energy resource-efficient and cost-effective solutions to meet end-users’ low carbon cooling demand.


**Keywo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Aberrant gene expression and muscular dystrophy: role of non-coding RNAs and alternative splicing in the pathogenesis and potential therapies' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Our goal is to characterize the molecular pathogenesis of facioscapulohumeral muscular dystrophy (FSHD) in order to develop possible therapeutic approaches. FSHD is the third most important myopathy. Currently, no therapeutic treatment is available for FSHD. Unlike the majority of genetic diseases, FSHD is not caused by mutation in a protein-coding gene. Instead, FSHD is the result of a complex epigenetic cascade activated by deletion of a 3.3 kb subtelomeric non-coding repeat (D4Z4) located on chromosome 4q35. D4Z4 appears to be required for maintaining proper chromatin structure at 4q35 and its deletion causes de-repression of several 4q35 genes. Recently, we found that FSHD is caused by over-expression of the 4q35 gene FRG1 and we generated the first animal model of the disease. Our specific aims are: 1. To elucidate the mechanism underlying control of gene expression at 4q35. Our preliminary results suggest that non-coding RNAs and micro-RNAs generated by D4Z4 regulate chromatin structure and 4q35 genes expression. Our analysis will generate novel insights into the biological role of repetitive DNA sequences in higher eukaryotes. 2. To identify the pathways affected by FRG1 over-expression. We have recently found that FRG1 over-expression causes aberrant alternative splicing of selective genes. Using splicing-sensitive microarrays we will identify FRG1-dependent alternatively spliced transcripts and validate them using the FSHD mouse model. Our studies will elucidate the role of alternative splicing in the pathogenesis and will identify targets for therapeutic purposes. 3. To search for a possible therapy for FSHD. Based on our finding, we propose independent strategies aimed at controlling FRG1 activity to interfere with the progression of muscular dystrophy. In su