RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Functional interaction between a prefrontal and a thalamic nucleus for the consolidation of spatial memories' (METHA), addressing dissemination and exploitation.

assistant: **Impact**

Memory consolidation is the process by which memories are converted into a long-lasting form allowing its recall later in time. It has been shown that memory consolidation is supported by the coordinated activation of a network of brain regions. In this regard, the hippocampus-cortical communication has been largely studied. Recent evidences point to the thalamus as a key region mediating this dialogue. In particular, the Laterodorsal Nucleus of the Thalamus (LD) activity has been shown to be essential for remote memory recall. Moreover, the LD shows high anatomical and functional connectivity with the Anterior Cingulate Cortex (ACC) which is a key structure for consolidation and remote memory recall. These data suggest   that this LD-ACC pathway may be crucial during memory consolidation. The LD is known to harbor Head Direction (HD) cells which are neurons that fire to specific orientations of the animal head. Therefore, we hypothesized that the activity of the LD-ACC circuit represents spatial information that is required for recall of contextual fear memory. The present project was designed to test this hypothesis using a multi-level approach, that is unique in the field. First, we will address the causal role of the LD-ACC pathway in the recall of fear memory, by modulating its activity using optogenetics. Then we will investigate how LD cells, and LD-ACC projecting cells, are processing acquired information during the training to consolidate and recall them at a remote time point by directly visualizing the activity of the LD during acquisition and recall of contextual conditioned fear. The expected results will have a significant impact in the memory and in the spatial navigation field, and are of key importance to better understand memory and related pathologies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'South american bites and stings programme' to be submitted under Fourth Framework.

assistant: **Abstract**

* To investigate and improve therapy of bites and stings in different areas of Brazil and Ecuador by clinical testing of antivenoms.* To investigate the extent of the problem of bites and stings in the above areas.* To investigate the efficacy of plant extracts as possible alternatives to conventional antivenoms.* To develop enzymes immunoassay as a tool for epidemiological studies, rapid immunodiagnosis and for studying the kinetics of envenoming and therapy.Expected Outcome* The optimum antivenoms and antivenom doses will be determined following preclinical tests and possibly clinical trials for use in central and Amazonian Brazil and Amazonian Ecuador.* Epidemiological studies will result in clarification of the extent of the health problems caused by bites and stings in Brazil and Ecuador.* The purification and testing of venom components will help in the possible development of novel drugs.Activities carried out are:* Preclinical experimental assessment of antivenoms before clinical studies (Liverpool).* Randomized clinical trials of antivenoms using clinical and laboratory methods (Belem, Uberlandia, Sao Paulo-Brazil, Shell Pastaza-Ecuador, Oxford-UK).* Laboratory tests on the pathological effects of venoms.* Isolation, purification and study of venom components.* Taxonomic evaluation of medically-important snake species and associated study of venoms from these (Sao Paulo-Brazil, Bangor-UK).* Epidemiological survey studies in Amazonian Ecuador and Brazil to establish the true extent of bites and stings in these areas (Sao Paulo and Belem-Brazil, Pastaza, Shell-Ecuador).* Enzyme-linked immunosorbent assay is being used as a tool for examining the kinetics of envenoming and therapy (Liverpool, Paris).* Isolates from various plants are being prepared in Hannover and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of a Forecasting Framework and Scenarios to Support the EU Sustainable Development Strategy' to be submitted under Sixth Framework.

assistant: **Abstract**

FORESCENE will develop an analytical framework for consistent environmental sustainability scenario building (forecasting, back-casting, simulation) in areas such as water, soil, biodiversity, waste and natural resources. Problem issues and priority policy fields such as agriculture, infrastructures/land use, industry/economy will be selected in close contact with the EU Commission. The project will focus on back-casting, to identify different scenarios leading to the achievement of future targets.FORESCENE will- describe the chosen environmental problems, review policy objectives and indicators, and determine the cross-cutting driving forces;- develop core elements of integrated sustainability scenarios (goal definition);- determine measures and processes to be considered for change (pre-back-casting);- address quantitative and qualitative parameters for measurement (parameterization);- develop a Business-As-Usual (BAU) scenario framework and example projections (forecasting);- develop alternative scenarios (incl. Back-casting);- check the options for modelling, and- work out conclusions.To integrate the eight steps FORESCENE will organize a series of workshops to involve DG's and stakeholders, to integrate knowledge on- cross-cutting drivers of various environmental problems and priority policy fields, and- to define essentials for integrated sustainability scenarios in terms of goals and cross-cutting policy measures.Further experts will be involved at various stages of the project. The project will result in recommendations for future policy development with regard to the EU's sustainability strategy and the framework for Impact Assessments and concrete proposals for the use and extension of existing simulation models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Electrifying Peptide Synthesis for Directed Evolution of Artificial Enzymes' in the context of a Horizon Europe call.

assistant: **Objectives**

Global climate and energy challenges require efficient, robust and scalable catalysts for the conversion of renewable energies. Nature has evolved extremely active catalysts (enzymes) for the conversion of small molecules relevant to energy (H2, CO2, N2). The scalability of these enzymes offers distinct advantages over the rare, precious metals that are currently used in energy conversion. Unfortunately, the enzymes are unable to tolerate the extreme conditions of operating fuel cells or electrolyzers. Directed evolution is a powerful approach for improving enzymes, but is mostly restricted to natural amino acids and biological conditions, with limited compatibility for evolving enzymes toward enhanced resistance in abiotic systems. Here, I aim to establish directed evolution in fully abiotic systems, using artificial amino acids to make artificial enzymes that are stable even in extreme conditions. Towards this, I will establish new electrochemical peptide synthesis platforms to enable the generation of enzyme-length peptides using both natural and artificial amino acids. Extended libraries of artificial enzyme variants will be produced and screened directly on electrode microarrays. Top enzyme candidates for the conversion of H2 will be selected using fuel cell/electrolyzer conditions as the evolutionary criteria. By the end, I will have a new procedure for synthesizing libraries of full-length artificial proteins, enabling the creation of thousands of enzyme variants using artificial building blocks. The generation of high-quality datasets will be transformative to drive future machine learning-based evolution steps for both full size enzymes and small-molecule catalysts with applications beyond H2 evolution. We will have discovered highly active catalysts able to su
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Computerised Bibliographic Record Actions Plus Preservation and Service Developments for Electronic Publications' in the context of a Fourth Framework call.

assistant: **Objectives**

This is a concerted action, involving national libraries in Europe. Its main goals are to build on a concertation activity (CoBRA) set up in 1993 to promote initiatives and actions in the area of national bibliographic services at a European level. CoBRA+ consolidates previous work while widening its focus beyond national bibliographic services to include collection based issues particularly those concerned with electronic publications and related service developments in national libraries. Particular emphasis is placed on resource access and sharing, user needs and the use of communications networks to achieve these aims.Technical approachThe Steering Group of 8 national libraries works with the support of two main Task Groups. The first deals with metadata and bibliographic control and access, with particular reference to electronic publications. The second is concerned with examining issues and recommending actions in the area of electronic publications and digital resources. The task groups examine issues underpinning the development of future projects, and carry out small-scale, targetted technical feasibilities.There is also a steering group with the role of developing exploitation plans for the implementation and integration into the operations of libraries of both the results of projects currently being carried out under CoBRA and results from CoBRA + projects which become available.Key issuesAmong the main technical issues being explored are: bibliographic description for electronic and network publications and related access issues;subject access, authority control, language issues (particularly in a networked environment);networked information resource description and retrieval;digitisation techniques;implications of legal deposit of electronic publications;l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The role of adipose tissue in obesity: beta cell crosstalk', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Obesity is an emerging threat to European health and more effective and sustainable therapies are urgently needed to tackle it. Adipose tissue is acknowledged to be a key player in lipid metabolism and plays multiple roles in regulating whole-body physiology, through the secretion of hormones called adipokines. However adipokine secretion and its mediated crosstalk with other tissues are not well defined. This knowledge gap must be addressed to identify and exploit new therapeutic targets for reducing or reversing obesity and its complications. This is ADIBET's aim; to develop new knowledge and identify druggable targets by unraveling the molecular basis of adipose tissue regulation and crosstalk in vivo. ADIBET will take on 2 complementary tasks: explore adipokine-mediated crosstalk with beta cells and describe the effects of obesity on differential adipocyte function and secretion pattern. New knowledge in this area is a pre-requisite to developing new treatments for diabetes and can most effectively be delivered by industry-academic partnership. ADIBET combines 2 prestigious Academic partners and 2 promising European SMEs who will be working hand in hand, to forge a lasting partnership which will focus European academic research into the European market. ADIBET is a multidisciplinary scientific and training programme. The young or experienced researchers will acquire a broad range of skills from communication to functional omics, and from mathematical and computational modeling to intellectual property rights. The ADIBET partnership brings together state of the art tools, resources and know-how with a clearly structured human resource exchange programme to ensure efficient intersectorial transfer of knowledge. Thus,  ADIBET is an unprecedented opportunity to yield ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MULTI-valued and parallel molecular logic' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

MULTI replaces the familiar sequential model of computation that uses Boolean variables and combinational gates by logic operations that are executed in parallel on devices that have a built-in many state memory and whose inputs and outputs are multivalued. MULTI seeks to design, simulate and experimentally implement proof of principle devices on the atomic and molecular scale.MULTI refers to the unique novel characteristics of the proposed schemes. We use MULTI-level logic variables as opposed to two valued Boolean variables. We use MULTI-variate circuits that act in parallel so that more than one logic function is evaluated at every stage of the computation thereby aiming for parallel circuits. We use MULTI-state inbuilt memories. New functionalities and ground-breaking characteristics of information processing are provided by the radically post-Boolean MULTI approach. As a final thrust, MULTI will explore a post-Turing model of computation by using continuous variables.In MULTI a single atom, molecule or a supra(bio)molecular assembly acts as a logic element. We aim for new foundational principles and for proof of concept of computing in hardware at the level of laboratory experiments. MULTI plans to take advantage of internal degrees of freedom of atoms or molecules to implement logic operations by electrical addressing in the solid state and/or by optical addressing in solution. The dynamics offers time-resolved response and thereby enables parallelism that can be massive because of the many resolvable states. Internal states of different molecules can be made to communicate thereby providing for concatenation. The other route of MULTI is (bio)chemical recognition that offers exquisite control for implementing many state, optically readable finite state machines.Be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Wessex–Armorica: Territories, Connections and Hierarchies', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The aim of the WATCH project is to model the organisation of territories, economic and political connections, and social hierarchies promoted and sustained by maritime connections across and around the English Channel during the early Bronze Age (EBA). This study is crucial to understand how communities living in the Channel coastlands became interdependent at a time when trade in tin and copper was strenghtening the foundations for an extensive prehistoric European union. Central to the project is the study of burials within their human, social, and natural environments using Geographical Information System (GIS) analysis. The project is interdisciplinary, rooted in archaeology but borrowing concepts, methods, and data from geography and environmental sciences. This project will enable the fellow to achieve the research and transferable skills, which will allow him to become a mature independent researcher and international expert of the EBA northwestern Europe. The fellow will be able to apply the most up-to-date GIS skillset to different problems in the field of prehistoric archaeology, which will extend an exciting research career. This project offers the opportunity to the fellow to conduct innovative research and transnational mobility while providing benefits for the European Research Area, the Bournemouth University, the supervisor, the partner organisation and the fellow. This project will allow the fellow to develop a research agenda that will lead to a range of research and consultancy projects with European academic and non-academic institutions for the better understanding of EBA societies and cross-Channel relationships, thus enhancing research excellence and addressing recognized research questions in Europe, and beyond. Finally, the fellow aims to offer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Application for an AI Factory in Austria' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

AI:AT – the AI Factory Austria – is a national initiative aimed at sustainably strengthening Austria's AI ecosystem. Through state-of-the-art supercomputing infrastructure, targeted support services, and a strong partner network, we are laying the foundation for powerful, secure, and economically viable AI applications.Funded by the European High Performance Computing (EuroHPC) Joint Undertaking, AI:AT makes a central contribution to Europe's competitiveness and innovation capacity in the field of artificial intelligence.With AI:AT, a key building block for a Europe-wide visible AI ecosystem is being created. We are fostering synergies with flagship projects such as the planned AI Center at the University of Vienna and TU Vienna, the biomedical AI institute AITHYRA, and the FWF Excellence Cluster Bilateral AI.In this way, AI:AT – the AI Factory Austria – sustainably strengthens Austria's international position as a hub for technology and innovation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Reimagining Urban Growth in the Mérida Region through Long-Term Adaptive Indigenous Practices: An applied archaeology for sustainable urban development'.

assistant: **Innovation**

REMIND strives to enhance the appreciation of indigenous urban form and practices that can benefit sustainable urban development. The Urban Region of Merida (URM), Mexico, experiences unsustainable rapid urbanisation. Weak urban planning policies and globalised urban design generate problematic urban patterns that marginalise the relevance of precolonial Maya rural-urban integration, indigeneity persistent in current urban life, and vernacular urban design. In contrast, URM accommodated urban centres for >2,000 years through social-ecological pressures and societal transitions. To envision regionally appropriate sustainable urban planning and design requires understanding how urban form adapted over the long-term. Thus REMIND asks:How can indigenous Maya practices be applied in urban development processes to substantiate a reimagination of urban space that promotes the future sustainability of Mérida?To address this question, REMIND will first adapt urban resilience concepts for the analysis of material evidence on urban form over the long-term, enabling an actionable ‘applied archaeology of indigenous urban practice' serving regional development. Next, through micro-morphological mapping of urban centres through time in a historical Geographical Information System (HGIS), spatial patterns of urban form will be identified, characterised, and compared. This fundamental research will structure and be guided by two cross-sectoral co-productive capacity building workshops, which match multidisciplinary academic expertise to institutional stakeholders in URM’s sustainable development and heritage to generate leverage for alternative approaches to urban planning and design. Together, participants will ultimately co-create reimaginative ‘indigenous urban development principles
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Functional food, gut microflora and healthy ageing' (CROWNALIFE).

assistant: **Concept**

Elderly people represent an increasing fraction of the European population. Their higher susceptibility to degenerative and infectious diseases lead to rising public health and social concerns. Appropriate preventive nutrition strategies cane applied to restore and maintain a balanced intestinal micro flora exerting protective functions against the above disorders. The present program is based on the application of selected biomarkers in hypothesis driven human studies. We will identify structural and functional specificities of the alderfly's intestinalmicroflora across Europe. Using this baseline information, we will investigate functional food based preventive nutrition strategies aiming to beneficially affect the functional balance of the alderfly's intestinal micro flora. Expected outcome include nutritional recommendations as well as new concepts and prototype functional food specifically adapted for health benefits to the elderly population.