RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Genetics to understand cellular components of Alzheimer Disease pathogenesis', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Alzheimer disease (AD) is a major health problem worldwide. New therapies require an accelerated translation of genetic information into mechanistic insights. Given limitations of rodent models, fully humanized models are needed to capture the complexity of the disease process. Human stem cells (iPS) provide great possibilities but are largely investigated in vitro with associated limitations. Many of the novel genetic risk factors for AD are expressed in microglia and astroglia, which remains an understudied population in this classically neuron-centric field. We propose here mouse-human chimeric mouse models to test the effects of AD-associated genetic risk factors on the phenotypes of transplanted microglia and astroglia derived from patients and from genomic engineered, isogenic stem cells. The cells will be followed during disease progression in brain of wild type and of mice developing Aβ- and Tau- pathology. Using single cell transcriptomics, a dynamic view of the cell states over time is generated. In a first arm of the project, we investigate how the genetic makeup of patient derived stem cells with high and low polygenic risk scores influences pathological cell states. In the second arm of the project, we generate inducible Crisper/CAS9 iPS isogenic cell lines to manipulate rapidly and specifically the expression of 4 selected AD associated genes linked to a putative cholesterol pathway but also affecting inflammation. These cell lines will be used also in the second phase of the project when validating hypotheses generated from the extensive bioinformatics analysis of the 600.000 single human cell profiles generated. We expect to identify and validate >5 novel drug targets in the astroglia-microglia axis of AD pathogenesis. Our work provides humanized models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Modern Equation of State for Electrolytes' to be submitted under Horizon Europe.

assistant: **Abstract**

The objective of this project is to develop and make available in various forms an equation of state for electrolyte solutions, eSAFT-VR Mie, developed during the ERC project ""New Paradigm in Electrolyte Thermodynamics"". The model can be applied across a wide range of temperatures, pressures, and solvents, solving the problems of currently used models in industry and research. We aim to integrate the model into a user-friendly tool featuring a Guided User Interface (GUI) and a CAPE-OPEN or user model interface for commercial simulators, allowing the non-expert user to apply the model in day-to-day work. The tool and the user model will be available under various licences and conditions (1-academic use licence, 2-non-comercial industrial licence available to industrial consortia managed by the PI, 3- commercial use licence for any entity interested in buying it). This strategy will facilitate wider distribution and testing, thereby promoting the development of a robust tool relevant (but not limited) to industry and academia.""


**Keywords:** electrolytes, eSAFT-VR Mie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Beyond the Graft: Enhancing Clinical Outcomes through Aortic Biomechanics' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

This proposal aims to investigate the biomechanical mechanisms driving adverse aortic remodeling in patients with genetically triggered thoracic aortic aneurysms (TAA) following prosthetic graft surgery. The study seeks to identify critical features of both native aortic tissue and prosthetic grafts that contribute to the increased risk of distal aortic complications, such as dissection and aneurysm.These objectives will be achieved by:1.Advanced imaging and computational modeling: We will employ state-of-the-art cardiac magnetic resonance imaging (CMR) and 4D flow MRI to gather detailed pre- and post-operative data. This data will inform fluid-structure interaction (FSI) models to simulate the complex biomechanical interactions between grafts and the native aorta, providing insights that extend beyond traditional approaches.2.Biomechanical and genetic integration: By analyzing the stiffness and wall shear stress (WSS) of the aorta before and after grafting, and correlating these changes with clinical outcomes, the study bridges the gap between genetic predispositions and biomechanical responses. This approach will also explore the role of hemodynamic forces in driving the progression of TAA, helping to identify patients at higher risk for adverse outcomes.3.Tailored graft design: The proposal’s innovative approach includes the development of grafts with compliance tailored to individual patient characteristics. These tailored grafts, designed using FSI simulations, have the potential to reduce the risk of adverse remodeling, setting this study apart from others that use standard graft materials.This proposal advances personalized medicine by integrating genetic and biomechanical insights to enhance patient-specific treatment of thoracic aortic aneurysms. It aligns with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Simultaneous Trace Gas Detection Platform' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

In response to the European Council's revision of air quality directives in October 2024, there is an urgent need to improve monitoring of global pollution gas concentrations and develop effective air quality management strategies. Current monitoring systems operate on a coarse grid with limited sensors that only target specific trace gases, leading to the omission of critical pollutants like ammonia. This results in costly, complex, and inefficient monitoring.MULTI TRACE introduces the world's first field-deployed dual comb spectrometer platform, enabling real-time tracking of three vital trace gases including nitrogen dioxide and ozone. This innovative technology is unique in Europe for its capability to monitor multiple gasses simultaneously with high temporal resolution on the second scale. Trace gases are often interconnected through solar-induced reactions, complicating accurate concentration measurement; however, MULTI TRACE operates in a spectral range where strong absorption signatures for all gases under scrutiny are present.Field investigations will showcase the platform's capacity to monitor gas concentration fluctuations in varied urban and forested settings, confirming its versatility, innovation, and reliability. Collaborating with a leading laser company and engaging with stakeholders from different environmental sectors in Austria, we aim to create a prototype that surpasses current commercial devices in detection limits and temporal resolution.MULTI TRACE has the potential to transform gas monitoring applications not only for environmental sensing but also across industries like oil and gas, chemical manufacturing, and emergency services. Portable gas detectors are essential for safety, helping to identify leaks and monitor volatile organic compounds.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'iRhom2 in neuroinflammation and pathogenesis of Alzheimer’s Disease'.

assistant: **Innovation**

Alzheimer’s disease (AD) is the most common form of dementia in the elderly, a syndrome characterized by loss of memory and cognitive decline. AD has a dramatic socio-economical impact that is foreseen to worsen in the near future unless a cure is found. The pathology is triggered by the accumulation of Aβ oligomers that begins a cascade culminating with the formation of neurofibrillary tangles within the neuron and cell death. Neuroinflammation is emerging to play a key role in this process and it has been associated with the progression of the disease.  The rhomboid-like protein iRhom2 has been recently identified as a genetic risk factor for AD, even though the underlying mechanism remains to be characterized. iRhom2 recently emerged as a novel pro-inflammatory protein required to traffic TACE (tumor necrosis factor-α converting enzyme) towards the plasma membrane and guide its maturation, thereby regulating the release of TNFα, a cytokine implicated in several inflammatory diseases. Consequently, iRhom2-/- mice are protected from sepsis and rheumatoid arthritis, which involve TNFα-dependent inflammation. In addition, the concept is emerging that iRhom2 may regulate trafficking of additional clients other than TACE, thus controlling other signalling events in neuroinflammation. The main objective of this proposal is to characterize the role of iRhom2 in neuroinflammation and in the progression of AD. I plan to cross an AD mouse model with iRhom2-/- mice and evaluate role of iRhom2 in the progression of the disease. In addition, I will use avant-garde proteomic approaches to identify novel iRhom2 clients in primary macrophages. Candidates relevant in neuroinflammation and AD will be further validated using an array of biochemical and functional assays. From this resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New strategies for the formation of two-dimensional covalent organic frameworks (2D-COFs) on surfaces.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Organic chemistry, including polymer synthesis, has a great impact on society, since many consumer goods would not exist without these chemistries. Most often, organic synthesis is carried out in solution and, despite the fact that it is a proven powerful approach, new synthetic strategies are needed for the formation of the next generation of complex materials. One kind of functional materials that receive great attention nowadays are the so-called two-dimensional covalent organic frameworks (2D-COFs). Basically, these are extremely thin films (one-molecule thick) that are often crystalline in two dimensions, and that contain nanopores. Potential applications of this type of materials range from superthin membranes to advanced electronics. This innovative project deals with the use of surfaces to template the formation of such sophisticated 2D-COFs. New synthetic approaches are explored, not only to generate the next generation of this type of materials with unique topologies and functionality, but also to conceive smaller versions of these 2D-COFs with a well-defined size. In this highly interdisciplinary project, we use atomically flat substrates that act as support for the formation of these new networks. These exciting novel 2D-COFs are not only of interest by themselves, but they also nanostructure and functionalize the surfaces they are adsorbed on.CustomCOF will provide an exceptional platform to acquire new knowledge through research and training, to reach scientific maturity, leadership and independent thinking, strengthening my team-working spirit, individual personal development training and my willingness to assume responsibilities and accept risks, which are always important assets to obtain high-quality results. It will offer networking opportunities and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tension of ENDOmembranes maintained by TORC1' (TENDO).

assistant: **Concept**

The target of the bacterial macrolide rapamycin, TOR, is a ser/thr protein kinase that assembles into two distinct protein complexes, conserved from yeast to human, we named TORC1 and TORC2. TORC1 is directly bound and inhibited by rapamycin and studies with rapamycin have revealed that TORC1 plays a central role in coupling nutrient cues to biomass synthesis and turnover. The lack of a specific inhibitor for TORC2 has made the study of this complex much more challenging. We overcame this challenge by solving the structure of yeast TORC2 which revealed why it is insensitive to rapamycin and enabled us to create a rapamycin-sensitive TORC2 variant. We also developed two small molecules, one that dissipates plasma membrane (PM) tension and the other that serves as a biosensor of PM tension. With this suite of chemical-biology tools we confirmed that TORC2 functions in a mechanotransduction pathway to maintain tension homeostasis of the PM. Concurrently, solving the structure of TORC1 revealed that its activity is regulated via assembly into a huge, inactive helix which we named a TOROID – TORC1 Organized in an Inactive Domain. In this grant, was ask if these major advances are transferable; i.e. can lessons learned regarding TORC2 be applied to TORC1, and vice versa? Our major aim is to determine if and how TORC1 regulates vacuolar membrane (VM) tension. To this end, we will develop novel chemical probes to monitor VM tension and we will use genetic screens, quantitative phosphoproteomics, in vitro assays, high-throughput compound screens, STORM and FRAP imaging, and state-of-the-art cryo-EM to learn how TORC1 senses and regulates VM tension. Our other aim, prompted by our TOROID discovery, is to solve the TOROID-like structure that TORC2 forms upon glucose depletion. Thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of Integrated MEasurement Systems' (DIMES) targeting Horizon 2020.

assistant: **Abstract**

The aim of the project is to develop advanced integrated testing methods that have the capability to detect a crack or delamination in a metallic or composite structure and have the potential to be deployed as part of an on-board structural health monitoring system for passenger aircraft. The proposal incorporates a new philosophy for monitoring damage in which the disturbance to the strain field in the structure caused by the damage is used to identify significant damage and to track its propagation. Recently, this approach has been demonstrated to be at least as effective in composite structures as traditional non-destructive evaluation techniques and, in CS2 project INSTRUCTIVE using infrared technology, it has been shown to be capable of identifying smaller cracks in metallic structures than any other available technique. In this project, it is proposed to amalgamate these innovations with more established techniques, such as strain gauges and acoustic emission, and to demonstrate an integrated testing method. The objectives are designed to mature technologies from TRL 4 to 6 that are likely to have a disruptive impact on the structural health monitoring of next generation large passenger aircraft The objectives are: i) to develop a robust and innovative concept for integrating a diverse set of sensors and data acquisition systems for detecting and monitoring damage in an aircraft assembly; ii) to produce an integrated system of sensors and data acquisition systems deployed on a test bench representing an aircraft assembly, and; iii) to conduct prototype demonstration and evaluation tests of the integrated system and test bench using independent systems. The primary outcome will be the demonstration, on a test bench consisting of an aircraft assembly, of an integrat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Multifunctional Hierarchically-Structured Systems for Energy Storage Devices' (MATISSE).

assistant: **Concept**

The widespread use of portable devices, as well as the electrification of transport, require a new generation of energy storage devices that deliver higher specific performance than Li-ion batteries. By designing multifunctional materials that combine structural and electrochemical energy storage, an improvement in gravimetric and volumetric efficiency can be achieved. The research aim of this project is to develop Energy Storage Devices based on multifunctional hierarchically-structured systems. The success of the project will be driven by the combination of two strong and complementary areas of expertise: At Imperial and IMDEA, the fellow will work for 24 months in groups with an extensive experience of carbon and inorganic nanomaterials synthesis, modification, characterisation, and application, particularly on hierarchical systems. On the other hand, she will bring her own experience in developing and characterising electrodes and electrolytes for a wide range of batteries as well as supercapacitors. The interdisciplinary intersection of new materials chemistry, with electrochemical device engineering, and structural composite mechanisms, will provide a unique opportunity for rapid progress in both science and technology. The structural energy storage devices will be developed from technology readiness level 1 and to 4, in order to accelerate direct impact on industrial applications, for example in the automotive and electronics sectors. During the two-year project, the fellow and supervisor will disseminate their results to Industry, Academia and General Public through patents and articles in podcasts, newspapers and scientific journals. From the start, an individual career development plan for the fellow will be developed with the supervisor and will be reviewed r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Lifshitz holography: hydrodynamics and the large-D limit' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Holography is the powerful statement that two seemingly distinct theories, a theory of gravity and a field theory, describe the same physics. In this proposal I focus on Lifshitz holography, a not very well understood version of the duality, that relates non-relativistic strongly-coupled field theories and gravity realized on Lifshitz spacetimes. The aim of the project is to further develop Lifshitz holography by taking advantage of recent progress in non-relativistic hydrodynamics and the development of the large-D tool. The research objectives(ROs), each forming a separate work package, are: - Flesh out the connections between gravity and fluid dynamics for non-relativistic theories, by developing the membrane paradigm for Lifshitz black holes. This will not only be a milestone in our understanding of Lifshitz holography itself and prepare the ground for a fully-fledged non-relativistic fluid/gravity correspondence, but it will also elucidate the infrared properties of these theories, identify universal behaviours in transport coefficients and other observables and explore the generality of recently-proposed connections between hydrodynamics, non-hydrodynamic modes and chaos. - Extend the large-D tool to Lifshitz spacetimes and then use it to study holographically thermal transport in Lifshitz theories. The large-D is a technical development in general relativity realised on Anti-deSitter and flat spacetimes that leads to major simplifications of gravitational dynamics and thus eases the complexity of calculations. This objective will impact both holographic studies and gravity considerations in Lifshitz spacetimes. To achieve these ROs, I will mainly study various aspects of quasinormal modes. These modes not only contain information about black hole dynamics in the