RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Reversal of anti-cancer drug resistance' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Worldwide in 2018, cancer has been responsible for around 9.6 million deaths, and with a prediction of a further increase in incidence over the next years – which calls for urgent better treatment modalities to combat such deadly disease. Resistance to anticancer therapy is considered the main obstacle to successful clinical management of cancer patients. Scandion Oncology A/S (SCANDION) is a clinical-stage biotechnology company aimed to solve the anti-cancer drug resistance problem. We are developing a new drug, the SCO-101, which effectively targets some of the most common molecular resistance mechanisms in cancer. SCO-101 represent a paradigm shift in treatment of drug-resistant cancer, with multi mechanisms of actions in interfering with drug resistance. SCO-101 has previously passed four clinical phase I studies in healthy volunteers and proved to be a safe oral drug with very limited toxicity. The SCANRESIST project aims at performing clinical validation studies in taxane resistant breast cancer patients with open-labelled Phase II prospective clinical trial to establish SCO-101 Proof of Concept as a safe and efficient treatment modality.Our business model is based on out-licensing SCO-101 to pharma players active in anti-cancer drugs – who will be responsible for the remaining clinical development and market launch. The Phase II clinical validation has been pointed as a critical step achieve a deal with big pharma partners/licensees, which we know are interested in novel drugs with novel MoA, and with well-designed and well-performed phase II studies with positive results. Thus, the project will not only open a large market for SCANDION as it will also allow us to position the company as a unique provider of a new generation of anti-cancer resistance drugs – cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Identification and analysis of novel mitochondrial proteins encoded by small open reading frames' to be submitted under Horizon 2020.

assistant: **Abstract**

Mitochondria are essential organelles with crucial roles in cellular energy metabolism, Fe-S cluster biogenesis, signaling and apoptosis. Mitochondrial dysfunction causes encephalomyopathy and neurodegenerative diseases. Mitochondria possess a remarkably high content of small proteins compared to other cellular compartments. About one third of the cellular proteins ≤15 kDa characterized to date are located in mitochondria. Functional examples of such small proteins cover the whole mitochondrial biology like cristae morphology, Fe-S cluster formation, metabolite transport, protein biogenesis and respiration. However, the intracellular localization and function of most small proteins is unknown. These small proteins constitute one third of the uncharacterized open reading frames and even three quarters of the dubious open reading frames in the model organism budding yeast. Taken together we predict that more than 10% of the mitochondrial proteome deserves to be discovered. In an initial study we demonstrated the mitochondrial localization of several uncharacterized small open reading frame (smORF) proteins. MITOsmORFs aims to identify over 100 novel small mitochondrial proteins. MITOsmORFs will determine the submitochondrial localization and the functional role of the novel mitochondrial proteins by genetic, proteomic, metabolomic and lipidomic analysis, including interaction mapping and characterization of mitochondrial activities in vivo and in organello to explore the unknown biology of smORF proteins localized to mitochondria.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quantum dynamics of floppy systems beyond Coulomb interactions: magnetic and parity-violating effects' under Horizon Europe.

assistant: **Concept**

Chemistry is developed with the improvement of experimental and theoretical spectroscopy. A well-known approach for molecular vibration is based on harmonic oscillators, but it cannot be used for floppy systems. To analyze spectra of floppy systems, the exact quantum dynamics (QD) methodology based on a numerically ‘exact’ solution of the (ro)vibrational Schrödinger equation has been developed. It may appear that ro-vibrational spectroscopy is well established, based on the electronic Schrödinger equation with Coulomb interactions, but two additional effects that split molecular spectra remain: a) magnetic interactions due to nuclear spins, and b) parity-violation interactions, which is due to the electroweak force, causing tiny energy differences between enantiomers. The magnitude of a) is on the order of several tens of GHz (109 Hz), which is observable in the high-resolution spectrum. The magnitude of b) of a current target molecule is predicted about a few mHz (10-3 Hz), which is smaller than the current precision of the best experiments. The suggestion of new target molecules with large PV effects is required. These effects have been investigated for rigid systems, but never for floppy systems, where new coupling of ro-vibration and magnetic interactions, and strong enhancement of PV effects may be present. In this project, I investigate a) and b) of floppy systems by developing new QD methodology and by obtaining molecular properties (spin-rotational constant and PV energy), based on electron correlation theory. The objectives of this project are as follows: i) formulation, implementation, and application of QD with magnetic interaction for floppy systems, ii) theory development of QD for methanol-like molecules, and iii) QD application for chiral methanol-like mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Human pre-t cell receptors - cellular and genetic analysis'.

assistant: **Objectives**

Most antigen receptors on T lymphocytes are alpha beta TCR/CD3 complexes and are acquired somatically during T-cell development. It has been a dogma that individual subunits in the TCR/CD3 complexes are not transported to the cell surface but require prior assembly into such compound receptors. In addition, the full set of TCR and CD3 subunits would be required for the surface display of the TCR/CD3 complex. Considering that the rearrangement and expression of alphaTCR is a late event in T-cell development, the model predicts that neither TCR nor CD3 subunits would be implicated in the early selection processes occurring in the pre-T cells which are the key to shape the immune repertoire. The evidence for a role of TCR negative/CD3 containing surface complexes on mouse pro- and pre-T cells from mutant mice contradicts this model. The recent cloning, by H. von Boehmer and coworkers, of a gene encoding a component of a 'surrogate' alphaTCR subunit, termed preTalpha, opens a new exciting avenue to understand better the selection processes related to the establishment of tolerance; and interestingly parallels the one for Ig *H and *L chains in the immunoglobulin/CD79 complex and beta-cell development. The candidate for this HCM Return grant aims to carry out the cloning of the human preTalpha homologue, the expression and purification of recombinant fusion proteins from it, and the subsequent characterization of monoclonal antibodies specific for human pre Talpha product on pro- and /or pre-T cells. The host laboratory has expertise in the field of human T-cell development and TCR/CD3 complex and has carried out a related project on human *L/VpreB using an approach similar to that proposed here.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Electromobility solutions for cities  and regions' (2007-2013).

assistant: **Concept**

The overall goal of the proposed project is to promote more sustainable transport through the development of electromobility solutions for cities and regions (ELMOS). The projects aims at delivering concepts for a better exchange of electromobility knowledge at regional and EU level, concepts for new business models and for cross-border field tests which should lead to an improved standardisation in electromobility technology and to new insights in applied science. The project therefore, contributes to enhance the regional capacities for a fostering of the sustainable transport-related economy.Electric vehicles are regarded as one of the cleanest solutions for urban mobility. Due to daily congested roads in and around agglomerations with highly polluting stop-and-go traffic, electromobility with zero-emissions in cities will bring large and quick gains in greenhouse gas reduction and alleviation of air and noise pollution. Moreover, innovative green vehicle concepts will lead to new and sustainable mobility forms in urban mobility. Some already see a new electric mobility age to come up.However, a fast uptake of electromobility depends on appropriate regional infrastructures, a shift in user patterns, and intelligent vehicle-use concepts embedded in the urban transport environment. The market potential is considered to be enormous.The working scheme is designed to achieve these objectives: High-level expert round tables and international networks will gather additional expertise. Two EU-mentoring regions are involved from the start. From the sectors ICT, automotive and renewable energy, four ma-ture and two less RDCs in geographically linked regions participate. Their intended set-up of joint concepts for electromobility cross-border testing has never been done so far.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pine protection against Pitch canker through genetic resistance and plant immunization' in the context of a Horizon 2020 call.

assistant: **Objectives**

Pinus is one of the most ecologically and economically significant tree genera in the world having an extreme economic importance to wood and paper industries. Pine pitch canker, caused by the fungus Fusarium circinatum, is an introduced non-native pine disease in natural and planted stands of Europe subject to quarantine measures. To date, there are no suitable approaches available to control this threat, being associated with elevated economic losses to the forestry sector. “Plant immunization” or priming, is pointed as the safest and most effective biotechnological approach to boost the endogenous plant immune system. Phosphites (Phi) have been shown to activate plant resistance acting in a dual way, both at the host and fungus level. PlimPine project has been built on the basis of ecological, industrial and socioeconomic importance of European pine forests, combined with the fact that short research is conducted on F. circinatum in Europe. We propose a substantially cross-disciplinary (from physiology to Omics) and ambitious, but feasible, project to create knowledge and tools to explore the intricate defence system against pathogens for forest trees, having Pinus-Fusarium interaction as a model. This project aims to characterize and identify markers of resistance (natural or induced) to pitch canker disease based on solid and exciting preliminary results. Deciphering the mode of action of Phi will help in the preventive application as a viable alternative for the pitch canker management, contributing to the European forest management.


**Keywords:** Pinus, Pitch Canker, Plant Immunization, System biology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Preparation for Moldova’s integration into the European Research Area and into the Community R&D Framework Programs on the basis of scientific excellence' under Seventh Framework.

assistant: **Concept**

The objective of MOLD-ERA is to assist the Institute of Electronic Engineering and Nanotechnologies (IEEN) to develop and implement a research strategy that will expand its activities and increase its level of excellence, so that it can compete and collaborate with leading research institutions in Europe. MOLD-ERA training activities will be opened up and integrate with activities in other relevant research institutions in Moldova to increase the project impact and thereby increase the generation of wealth in the region. Focus is on a new research and training program for young researchers that will result in creation of a leading European infrastructure at IEEN in nanotechnology and nanobiology. This will be implemented through:- Combining existing facilities at IEEN in the field of Nanotechnology with new equipment to be purchased to extend this research area to Nanobiology with a focus on the properties and structure of complex assemblies of biomolecules, such as biochips, molecular motors and membrane assemblies in conjunction with the distinctive surfaces, rods, dots and materials of nanoscience.- Establishment of a nanobiology training program to integrate the principles of nanoscale science and biology in research and coursework for the development of a new generation of nanobiologists. This will include (i) theoretical courses for PhD and Master students in the fields of biocompatibility of electronic and photonic materials, transformation of bio-signals in electric signals and vice-versa, extra and intracellular bioelectric signaling, biotoxicity and related disciplines; (ii) practical training of young researchers from the IEEN at leading European research centres in the areas of nano-bio, nano-medicine etc.- Training modules will be provided to assist researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DESigns for Inter-urban Road pricing schemes in Europe' under Fifth Framework.

assistant: **Concept**

DESIRE will assess distance based inter-urban road pricing in Europe, focusing on heavy vehicles and considering future extensions towards other type of vehicles. It will provide guidelines not only for the design of those schemes but also ways to overcome its implementation difficulties. The main output of DESIRE is the production of guidelines and recommendations that will help policy makers in defining and setting up policies for a more efficient use of existing road networks, with the consequent improvements of efficiency and effectiveness in the dynamics of economic and social relations. DESIRE will provide a systematic approach to pricing schemes on heavy vehicles to allow the identification of every possible scheme over any preconceptions that may exist on the subject. DESIRE is organised along 6 phases with a continuous feedback form the real world"."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Support for the Intergovernmental Panel on Climate Change (IPCC) to facilitate the preparation of its next Assessment Report'.

assistant: **Objectives**

The Intergovernmental Panel on Climate Change (IPCC) is the key global climate science-policy interface, underpinning European and international climate change policy-making and is the leading global body responsible for the scientific assessment of climate change. In preparation of the next Assessment Report, support will be provided to increase the participation of experts from developing countries and EU countries, should their governments be unable to provide appropriate funding, consistent with IPCC practices, to the IPCC process and enhance visibility of the IPCC goals in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Co-creating resIlient and susTaInable food systEms towardS FOOD2030'.

assistant: **Objectives**

Urban food systems and ecosystems (UFSE) demand immediate action. CITIES2030 innovative approach have a great opportunity to attract the best researchers, entrepreneurs, civil society leaders, cities and all agents of the UFSE as well. The main goal of CITIES2030 is to create a future proof and effective UFSE via a connected structure centered in the citizen,  built on trust, with partners encompassing the entire UFSE. CITIES2030 commit to work towards the transformation and restructuring of the way systems produce, transport and supply, recycle and reuse food in the 21st century. CITIES2030 vision is to connect short food supply chains, gathering cities and regions, consumers, strategic and complement industry partners, the civil society, promising start-ups and enterprises, innovators and visionary thinkers, leading universities and research across the vast diversity of disciplines addressing UFSE, including food science, social science and big data. CITIES2030 actively encourage the participation of citizens by delivering a trusted UFSE, moving consumers from being passive recipients to active engagement and motivated change agents. This objective is achieved via multiple tools delivered by CITIES2030 such as the CRFS Alliance, a community of practice supported by a digital platform, reaching all over Europe and beyond. This approach will enable policy developments, innovation actions within result-driven Labs, and enhancements on a pan-European scope with a global reach. Cities and regions will improve resilience and sustainability, and their leadership will create short food supply chain and ecosystems enabling local investments, trans-borders and transnational deployment. A blockchain-based data-driven UFSE management platform will secure intelligence and coordina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Graphene as effective anti-fading agent for the protection of artworks' to be submitted under Horizon 2020.

assistant: **Abstract**

All art materials are prone to degradation; in particular, the introduction of new creative manufacturing techniques in the 20th century art has yielded artworks with short lifetime expectancy. Fading, yellowing and discolouration are the most common degradation effects that result from the exposition to UV and visible light and oxidizing agents. The result of the degradation is the irreversible alteration of the appearance of contemporary artworks, which is a patrimony of mankind. This PoC project aims to develop innovative, multi-functional graphene-based products (graphene ‘veils’ and inclusions) that provide UV shielding, de-acidification, oxygen and humidity barriers for the protection of old and modern paintings and artworks. Recent advances in the understanding of the mechanical integrity of large graphene membranes as well as of innovative graphene-transfer processes through the current ERC Tailor Graphene has made possible the emergence of this application of strong societal value. The transparent protective graphene veil can be easily removed so it does not constitute an irreversible intervention on the art object. Moreover, for such an application the price of graphene does not hamper its business potential since the quantities are minimal. Two different classes of products are envisaged; CVD graphene membranes directly deposited to artworks for which transparency is required and graphene flakes that will be dispersed to colour paints and varnishes so as to bestow enhanced UV, oxidation and humidity resistance. The latter paves the way to extend this application to the huge market of architectural paints. A multi-disciplinary approach will be pursued for the implementation of this PoC and involves experimentation with CVD graphene sheets of various morphologi