RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Chromatin readout: Dissecting the  protein-chromatin interaction code in living cells' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Chromatin modifications are key regulators of genome function. They can be directly recognised by specialised protein reader domains, leading to coordinated recruitment of regulatory proteins to the genome in a dynamic, spatiotemporal manner. Despite many efforts to characterise chromatin-mediated protein recruitment, the underlying principles that determine specificity and how chromatin marks influence the proteome composition at genomic sites in living cells, remain unclear. Here I propose to uncover the underlying logic that mediates specificity between regulatory proteins and chromatin states by using a reductionistic approach that enables us to study these interactions in a controlled and comprehensive manner in living cells. Towards this we combine high-throughput stem cell engineering with functional genomics and computational methods to achieve the following aims: First, we aim to identify and characterise the genome-wide binding preferences of a comprehensive panel of chromatin reader domains (CRD) by using a novel strategy for comparative profiling of multiple protein-genome interactions in parallel. Second, we will systematically dissect the context-dependent determinants that mediate individual and combinatorial CRD binding to the genome. Finally, we will utilise the selectivity of CRDs to uncover the local proteome at defined chromatin states in ES and neuronal cells, revealing novel components involved in the regulation and organisation of the epigenome. The overarching goal of ChromatinLEGO is to elucidate in a systematic, quantitative and unified manner,  how protein-genome interactions are guided by specific chromatin modifications. Through identifying the chromatin-dependent recruitment principles of regulatory factors, and by dissecting the underlying
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deciphering the Negr1 interacting network in physiological conditions and in psychiatric and neurodevelopmental disorders.' to be submitted under Horizon 2020.

assistant: **Abstract**

There are no therapies for the core symptoms of most psychiatric and neurodevelopmental disorders. Compelling evidence indicates that most of these disorders feature aberrant neuronal connectivity. Importantly, the neuronal growth regulator 1 (Negr1) is associated with neuronal connectivity and diverse brain disorders. Thus, a better understanding of how Negr1 exerts its functions may reveal general principles underlying these pathological conditions. Previous results show that Negr1 does not operate as single entity. Negr1 functions by physically interacting with other proteins. In this context, PSYNegrT will investigate the hypothesis that the brain’s Negr1 interacting-protein network is remodeled in psychiatric and neurodevelopmental disorders. The fellow will investigate the role of specific Negr1 complexes in diverse brain disorders and their possible exploitation as drug targets. To this aim, he will identify and characterize the brain’s Negr1 interacting-protein networks by proteomic, biochemistry, and molecular biology studies. Computational and mutagenesis studies will reveal structural features for molecular interactions at the interface between Negr1 and selected partner proteins. This project will thus: i) produce the first exhaustive list of cerebral Negr1-interacting proteins in physiological conditions ii) identify the protein-protein interactions involved in Negr1-mediated pathological effects.With PSYNegrT, the fellow will increase his research skills and expertise in molecular biology and modeling, thus flourishing into an independent group leader. The project will be a breakthrough in our understanding of the causes of diverse brain disorders, and it will reveal certain general principles underlying their pathophysiology. This will facilitate structur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Untangling the network of RNA silencing pathways in plants' under Seventh Framework.

assistant: **Concept**

This project aims to understand RNA silencing pathways in plants using the unicellular alga Chlamydomonas reinhardtii as a model. The aim is to characterise the different modules in the RNA silencing pathways, the ways that they interact to form complex regulatory networks and the effect of these networks on growth and development. The initial approach will involve genetic and molecular characterisation of components in RNA silencing machinery. Having identified these components, I will then use different approaches to modify the different modules and assess their involvement in growth and progression of the algal life cycle. Chlamydomonas is an appropriate model because it has RNA silencing pathways that are simplified versions of those in higher plants, but in which there is still the potential for complexity given the existence of different types of pathways associated with suppression of gene expression at the RNA and chromatin level. In addition, because Chlamydomonas can be cultured synchronously, it is possible to carry out a system level analysis of regulatory networks: the extracts will represent the content of a single cell type at a defined stage of the cell cycle whereas with higher plants there are complications for this analysis associated with different cell types.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Strategy to build up and maintain an integrated sustainable European fungal genomic database required for innovative genomics research on filamentous fungi important for biotechnology and human health' (EUROFUNGBASE), addressing dissemination and exploitation.

assistant: **Impact**

Wide spread genomic research leads to enormous amounts of data which will be stored in many small databases all over Europe. For integrated European genomic research it is important that such data become easily accessible for all researchers. Therefore, a strategy is developed to build up and maintain an integrated, sustainable European genomic-data base required for innovative genomics research of filamentous fungal model organisms of interest. This database will become a crystallisation point for related systems and then could be integrated and conserved in a central European genomic database.Filamentous fungi are of immense importance both in biotechnology and in human health. The human pathogen Aspergillus fumigatus is causing thousands of deaths annually in Europe. Other fungi are important cell factories for the production of many types of compounds including antibiotics, cholesterol-lowering agents, immuno-suppressors, and enzymes. To identify novel drug targets and diagnostics, and to develop new biotechnological processes, it is important to understand the filamentous fungal cell. The recent release of complete genomic sequences for several filamentous fungal species, offers a unique opportunity to rapidly capitalize on the wealth of knowledge in Europe on filamentous fungi. EUROFUNGBASE will ensure that Europe grasps this opportunity by developing the platform for the development of a European fungal genomic-database, appropriate information systems, and standardization procedures. Furthermore EUROFUNGBASE researchers in the European biotechnological fungal research community will be trained in state-of-the-art techniques for using the database for their own genomics research. The CA program will provide the appropriate conditions by organizing a series of exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Towards size effects in nanosized ferroelectrics - fabrication of nanocrystals by self-assembling methods'.

assistant: **Concept**

Nanotechnology is expected to have a big impact on most of our life. Nanostructred materials become more and more important in various fields such as nanoelectronics, information storage technology etc. At the nanometre scale, i.e. 1-100 nm, material properties are clearly size-dependent and new properties are expected. Among functional materials nanoscale ferroelectrics can have a major role because they can be applied in different fields such as sensors, actuators, memory devices and optics. However they cannot be applied to nanometre scale devices before the influence of the lateral size on physical properties will be clarified.In order to find answer for the problems there is a need to have good quality nanoscale structures. It is a challenge to fabricate such structures in this range using both lithography ('top-down' approach) and self-assembling and self-patterning methods ('bottom-up' approach). Whereas conventional lithographic systems work usually with a resolution of about 100 nm the bottom-up approaches allow the inexpensive fabrication of structures with size of 10-20 nm. The main goal of the work is preparation of nanosized ferroelectric crystals by self-assembling methods. Successful strategies and routes have been developed to synthesize nanoscale materials of numerous simple systems such as semiconductors or metals.Complex systems such as ferroelectric oxides are not yet systematically addressed, despite of the possibility of discovering new materials with unique properties. Physical route based on the concept of microstructural instability of ultra-thin films and chemical routes will be applied to obtain different perovskite crystals. A good quality of nanostructures that lateral dimension can be tuned in nanometre range is expected to fabricate and in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Promational-educational network for 6 framework programme common europe""' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Milestones:1. establishing the Organizing and Scientific Committee, 2. organizing the Information Day and Computer Workshops; 3. printing the conference materials and establishing web page.Expected results:- familiarize academic circles with the 6 FP,- providing equality of opportunities for scientists from various regions of Europe to take part in framework programmes of the European Union- establishing contacts, integration of contact points.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Evaluation of brain diseases by quantitative magnetic resonance metabolic, perfusion and diffusion imaging' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

To develop MR pulse sequences whereby perfusion, water diffusion, and metabolite concentrations can be quantified in human brain. Technical aims are to establish standard quality-assurance and clinical protocols and to evaluate the latter in multi-centre trials in normal controls and selected diseases. Clinical objectives are to apply these new techniques to normal developing and ageing human brain, Alzheimer's and multi-infarct dementias, and hypoxic and ischaemic disorders resulting in pathophysiological indices of importance for diagnosis and treatment monitoring.A better understanding of physiology and metabolism in normal, ageing and diseased brain may improve diagnosis and evaluation of new therapies in brain diseases which impose a large economic burden on health care systems and on society as a whole. The overall purpose of this project is to apply, in a collaborative multi-national programme, recent technical developments in magnetic resonance (MR) imaging of perfusion, diffusion and metabolism in the human brain to characterise: normal development and ageing processes, degenerative disorders and ischaemic and hypoxic disorders of the brain, in order to identify pathophysiological factors of importance for diagnosis and monitoring of treatment efficacy.The research programme involving ten competent European MR-centres, focuses on the development of a standard MR examination protocol for quantitative imaging of perfusion, diffusion and metabolism in the same investigation within a reasonable total examination time. Secondly, by means of this standard protocol in which the different MR-techniques are integrated, international multi-centre studies are launched in order to collect physiological, biochemical and clinical data characterising normal development, agein
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Gut immunity and homeostasis in Drosophila' (GUTDROSO).

assistant: **Innovation**

The gut is the major interface between microbes and their animal hosts and constitutes the main entry route for pathogens. As a consequence gut cells must be armed with efficient immune defenses to combat invasion and colonisation by pathogens.  However, the gut also harbors a flora of commensal bacteria, with potentially beneficial effects for the host, which must be tolerated without a chronic, and harmful, immune response.  In recent years Drosophila has emerged as a powerful model to dissect host-pathogen interactions, leading to the paradigm of antimicrobial peptide regulation by the Toll and Imd signaling pathways.  The strength of this model derives from the availability of powerful and cost effective genetic and genomic tools as well as the high degree of similarities to vertebrate innate immunity.  However, in spite of growing interest in gut mucosal immunity generally, very little is known about the immune response of the Drosophila gut.  Using powerful new tools and those developed in the study of the systemic response, we propose to raise our understanding of Drosophila gut immunity to the same level as that of systemic immunity within the next five years. This project will involve integrated approaches to dissect not only the gut immune response but also gut homeostasis in the presence of commensal microbiota, as well as strategies used by entomopathogens to circumvent these defenses. We believe that the fundamental knowledge generated on Drosophila gut immunity will serve as a paradigm of epithelial immune reactivity and have a wider impact on our comprehension of animal defense mechanisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'THE TAPHONOMY OF COLOUR IN FOSSIL INSECTS AND FEATHERS'.

assistant: **Concept**

Coloration is a multifunctional attribute of modern animals but its evolutionary history is poorly resolved, in part due to our limited ability to recognize and interpret fossil evidence of colour. Indeed, original coloration was considered one of the most enigmatic aspects of the biology of ancient organisms, but recent studies on fossil feathers and the cuticles of fossil insects have led to advances in the field. Research to date, however, has focussed on very specific aspects of colour, i.e. fossil melanosomes in feathers and structural colours in fossil insects. As a result, key aspects of the fossil record of colour in insects and feathers are unknown, and the evolutionary histories of the diverse colours and colour patterns deployed by modern insects and birds are poorly resolved. The innovative and multidisciplinary research proposed herein will resolve these issues by employing a powerful three-fold approach combining decay experiments, maturation experiments and fossil analysis to the study of the taphonomy of key pigments (melanins, carotenoids and pterins) and colour-producing structures in insects and feathers. Experiments will simulate the processes of autolytic decay and deep burial, and will elucidate, for the first time, the chemical steps involved in the alteration of key pigments in insects and feathers during decay and diagenesis, and the extent to which this process, and alteration of structural colours, is impacted by sedimentological and taxonomic factors. The experimental results will ground truth data obtained from comprehensive analysis of diverse fossil insects and feathers from the Cenozoic and Mesozoic, facilitating the first systematic attempt to map preservation of colour in fossil insects and feathers through deep time. In doing so the re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Population genetic studies of loci in the incompatibility - s-locus - gene family in self-compatible and self-incompatible plant populations' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content We plan to do genetic studies in natural populations of Antirrhinum. After collecting a large sample of plants from two different geographical populations, we plan to establish genetic distances between populations, using allozyme genetic markers. These results will also be helpful to verify the breeding systems of these populations which can be estimated using genotype frequencies at several allozyme loci. This results will be confirmed with controled plant crosses. Sequence data on the self-incompatibility S-locus, will be used to estimate diversity levels at this locus, and will provide us with tools to test theoretical models on the relationship between levels of genetic diversity and levels of inbreeding. It will also be used to identify regions of the S-locus that are functionally important. Diversity in inbreeding and outcrossing populations at S-related loci will also be estimate, using the same technical approach. Training content (objective, benefit and expected impact) The molecular biology work I did previously at the Daniel Hartl laboratory (Harvard University) gave me not only the necessary technical training for this project, but also some theoretical training in population genetics and evolution. The proposed work will improve my skills in molecular biology, but also, and most importantly to explore a more theoretical evolutionary aspect, complementing my previous formation. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Evaluating financing of forestry in europe' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Many countries have been reforming their forest policies in order to respond to the requirements of economical, ecological and social sustainability. Consequently, policy targets have become more complex compared with the past situation. In addition, the Community Measures have increased their relevance in forestry. With this project proposal, we are aiming to enforce the emphasis on evaluation research of forestry funding in EU and EFTA countries, and in selected Countries in Transition (CIT). The public intervention costs in a common and normalised basis will be estimated to allow for regional comparisons. The effectiveness, efficiency and equity of alternative public financing programs will be also assessed. The results will increase understanding and transparency of government actions in forestry, provide information for designing public policies in forestry and decrease the social costs by establishing policy reorientations in order to avoid intervention failures. Further, the CIT will have access to research based tools for reforming their forestry sectors.