RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Photo(electro)catalytic Nitrogen Fixation' (NITROGEN-LIGHT).

assistant: **Innovation**

Despite the intensive effort on nitrogen photofixation, there is a clear gap in the design of the catalytic system at the molecular/atomic level: at the same time, the majority of literature examples for nitrogen photo(electro)reduction employed only Uv-Vis semiconductor based systems with poor control on the molecular aspects of photo(electro)catalysis.  NITROGEN-LIGHT lies in the panorama of nitrogen reduction, but offering a new point of view. This project aims to develop a photoelectrolyser to efficiently convert nitrogen to ammonia, but exploiting semiconductor surfaces decorated with controlled molecular assemblies of visible-light sensitisers and nitrogen-activating multi-redox catalysts. The advantage of the molecular design is the possibility to easily tune the redox properties of active sites and the stabilization of nitrogen-derived intermediates, with the final aim of: syncronizing photo-induced electron/proton transfer (PCET), lowering the energy barrier and optimizing the quantum efficiency. Success in this task will be instrumental for the fabrication of novel photocathodes for N2RR, to be integrated within a PEC device, in combination with photoanodes for water oxidation. The photoelectrode assembly for the final device will build on the state-of-the-art expertise and recent achievements of the CalTech and the Padova group, while frontier studies on the photophysics of selected molecular assemblies, to be performed with secondment visits at the Prague Institute, will guide the overall component choice and synthetic modification.


**Keywords:** Nitrogen reduction, Nitrogen photofixation, water oxidation, photo(electro)catalysis, artificial photosynthesis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Spatial and temporal control of self/non-self discrimination in innate immunity' in the context of a Horizon 2020 call.

assistant: **Objectives**

Recognition of nucleic acids enables detection of diverse pathogens by a limited number of innate immune receptors, but also exposes the host to potential autoimmunity. At least two members of the Toll-like receptor (TLR) family, TLR7 and TLR9, can recognize self-RNA or DNA, respectively, and contribute to the pathology of autoimmune diseases. Despite the structural and functional similarities between these two receptors, they can have opposing effects in autoimmune diseases such as systemic lupus erythematosus. My previous studies have identified a potential explanation for this enigma, whereby TLR7 and TLR9 experience a surprising degree of differential regulation, both at the level of receptor trafficking as well as receptor activation in the endosome. Although my work provides a major conceptual advance for explaining the distinct behavior of these two receptors in disease, we still poorly understand how the regulation of nucleic acid-sensing TLRs and its various interactions and pathways are embedded into the cellular architecture. Their cellular location is not trivial: knowing where in the cell these critical interactions take place and how they are coordinated in time is of utmost importance to fully understand how TLRs are regulated to avoid self-recognition. In this project, I aim to investigate these fundamental aspects of TLR biology using state-of-the art superresolution microscopy. I will use sub-diffraction imaging techniques including stochastic optical reconstruction microscopy (STORM) and Airyscanning technology to 1) define the precise subcellular localization of nucleic acid-sensing TLRs, 2) identify and characterize their endosomal signaling compartments, and 3) investigate TLR signaling dynamics under normal and autoimmune-prone conditions. This wo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Clarifying the role of Blastocystis in human intestinal disease' (BLASTOHIT2012).

assistant: **Concept**

It is now realised that the human intestinal microbiota is central to health and wellbeing. However, the vast amount of research into the human microbiome has focused primarily on the prokaryotic (bacterial) component of this complex microbial ecosystem and we understand virtually nothing of the eukaryotic species, such as the protists, that are known to play critical roles in structuring microbial communities in other natural ecosystems. Blastocystis is the most common protist in the human intestinal tract (IT); current estimates indicate that it colonises up to 1 billion people worldwide. Crucially, Blastocystis is considered to be an emerging pathogen, but its role in human illness and disease is both controversial and unclear.The key research goal of this project is to clarify the role of Blastocystis in human intestinal health and disease. For this project there will be a specific focus on Irritable Bowel Syndrome (IBS). We will analyse the prevalence and genetic diversity of Blastocystis in IBS together with healthy individuals and study the interactions between Blastocystis and specific intestinal bacteria. We will use an integrated series of state-of-the-art experiments encompassing both quantitative and qualitative analysis. These include a novel high-throughput PCR with high genetic resolution to assess Blastocystis variation in IBS and healthy groups, next-generation sequence analysis of IT bacteria, quantitative PCR, virulence assays, in vitro microcosm experiments and phenotypic assays.The novel interdisciplinary framework outlined in this proposal that combines molecular microbial surveys of the human IT with experimental microbial ecology and evolution, will allow us to address unresolved and original research questions. Data from this study also has the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Legitimacy, Sovereignty and the Public Sphere' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The goal of the research is to redefine the interrelations between the concepts of legitimacy, sovereignty, the public sphere and democracy in order to develop a conception of a more inclusive and participatory public sphere.The problems of participation in and inclusivity of the public sphere relate to recent trends of globalisation and democratic development in general. As for the latter it has been argued that democracy is hijacked by corporate interests and party bureaucracies that make decisions in their back rooms, excluding all public discussion, and as for the former, we can observe how globalisation brings together different peoples, cultures, religions, highlighting the question of openness to and acceptance of differences. This research project proceeds from understanding that tackling these issues means to deal with the problems of inclusivity and participation in the public sphere. This project differs from various re-conceptualisations of the public sphere or sovereignty that have been offered in response to these concerns. It returns to the original condition of possibility of the concept of the public sphere: my argument is that the mentioned problems with inclusivity and participation emanate from the unfinished conceptual separation between state and society. I argue further that the idea of legitimacy has to be tackled, if this conceptual separation is to be brought to its conclusion. My theoretical approach to these issues will be a conceptual analysis informed by Derridean deconstruction.This project is innovative as it is interdisciplinary in using conceptual tools of philosophy to reinterpret terms which are in use in our everyday political practice. The process of carrying out the research plan that also foresees publishing four scholarly article
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'NanoPlasmoMechanical Systems' (PLASMECS) under Horizon 2020.

assistant: **Objectives**

With their unparalleled mass and force sensitivities, nanomechanical resonators have the potential toconsiderably improve existing sensor technology. However, one major obstacle still stands in the way oftheir practical use: The efficient transduction (actuation & detection) of the vibrational motion of such tinystructures. Localized plasmon resonances ""focus"" optical fields below the diffraction limit of light andpresent a powerful new method to optically transduce the vibrational motion of nanomechanical structures.The objective of this project is to establish for the first time a complete plasmonic transduction in novelNanoPlasmoMechanical Systems (NaPlaMS). This new method is easy to implement and enables the freespaceaddressability and efficient transduction of mesoscopic (sub-wavelength) plasmonic pillar arrays. I willexplore the ground-breaking new properties of NaPlaMS pillar arrays in three mutually supportingsubprojects (SP). SP1 studies fundamental aspects of plasmomechanics by integrating nanoplasmonicantennas of various geometry and materials on highly force sensitive string resonators. These devices allowthe unique optical and mechanical study of i) plasmonic quantum tunneling and ii) optical forces betweenplasmonic nanostructures of various shapes and materials. SP2 will make use of the strongplasmomechanical light-interaction of the high frequency NaPlaMS pillars for the development of nextgeneration reconfigurable metamaterial for optic modulation. Compared to state-of-the-art bulky and powerhungrymodulators, NaPlaMS modulators will be low-power and sub-wavelength-size as required for futureoptic telecommunication and consumer products. SP3 utilizes the exceptional mass sensitivity of NaPlaMSpillar arrays to create unique mass sensors. The goal is to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Making the Franks: European Immigration and Citizenship in the Pre-Modern Ottoman Empire.'.

assistant: **Innovation**

This project explores the creation of norms on citizenship and naturalization in the pre-nineteenth-century Ottoman Empire. It focuses on European mercantile communities in three cities-Istanbul, Aleppo, and Izmir in the seventeenth and eighteenth centuries and on jurisdictional disputes between Ottoman and European officials over the legal belonging of European immigrants. Since that, before the nineteenth-century, a territorial-based notion of citizenship and universal identification systems did not exist in Europe and the Ottoman Empire, the political affiliation of European merchants and other immigration was often a matter of local controversy and diplomatic negotiations. These episodes of crisis, MAKEFRA argues, lead to the elaboration of internationally-recognized rules and practices over legal belonging, a proto-citizenship for European and Ottoman subjects. These rules, jointly elaborated by European and non-European actors, constituted the basis for modern-day systems of citizenship and naturalization in Europe and the Middle East.


**Keywords:** citizenship, Ottoman Empire, immigration, early Modern period, international law
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ageism: demographic changes and universal ethical principles' (1998-2002).

assistant: **Concept**

Methods of rationing healthcare increasingly appeal to age or life expectancy. The morality of such methods is controversial. This research will identify and ethical framework for the provision of publicly financed healthcare goods/services and ensure coherence with respect for fundamental ethical values and rights of each age group
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'In vivo study of primary B cell responses' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

B cells produce antigen-specific antibodies as part of the adaptive immune response. This is the result of a complex process of activation and differentiation that is initiated with the specific engagement of the Ag to the BCR. While a wide range of studies have been performed in vitro to understand B cell-Ag recognition, we still understand very little about the basics of motility, compartimentalization and Ag recognition in vivo, because these events occur in densely packed lymphoid organs. Only recently the development of new microscopic techniques has allowed to analyze B cell behaviour in vivo in immune tissues. The main aim of this project will be to understand the molecular parameters that modulate Ag transport, presentation, uptake and B cell behaviour in the lymph node. We will move from an in vitro approach (studying follicular dendritic cells-B cells interactions and Ag presentation) to an in vivo analysis of B cell fate and Ag transport in the lymph node. These studies will allow us to shade light in the molecular parameters that regulate B cell behaviour. Moreover, the analysis of the role of innante immune receptors in in vivo B cell responses will lead us to integrate the effects of the complexity of the immune response in B cell behaviour. Antibodies have demonstrated their value as bio-therapeutics across a wide spectrum of diseases, such as cancer, immune disorders, and infection. Thus, understanding what signals are required to effectively activate B cells and the principles driving the selection of high affinity B cell variants are key for the successful generation of highly specific antibodies. This knowledge can be applied in the long term to the design of more specific and effective therapeutic antibodies for the treatment and diagnosis of infecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Integrated Assessment of Health Risks from Environmental Stressors in Europe'.

assistant: **Concept**

This study is designed to support implementation of the European Environment and Health Action Plan, by providing the methods and tools that are essential to enable integrated assessment of environmental health risks. Drawing upon the large range of studies carried out in Europe over recent years (many led by the study partners) and the advances made in specific areas of toxicology and epidemiology (especially air pollution), and in close collaboration with users, it will develop a methodological framework and set of tools and indicators for integrated assessment that can be applied across different environmental stressors (including pollutants and physical hazards), exposure pathways (air, water, soil, food) and policy areas.It will review, bring together and enhance the monitoring systems needed to support such analyses, including routine environmental monitoring (ground-based and Earth observation), biomonitoring and health surveillance. The framework, tools and data will be tested and demonstrated through integrated assessments of exposures and health risks in a number of specific policy areas, including transport, housing, agriculture, water, wastes, household chemicals and climate. Results from these will be used both to refine the assessment methods and to provide specific information on health implications of current, and potential future, policies.Based on the results, a toolbox for integrated environmental health risk assessment will be developed, which will be further tested and demonstrated through a series of higher-level policy analyses. Particular attention will be given throughout to issues of uncertainty, sensitive or susceptible groups, and possible interactive and cumulative effects of different stressors. Deliverables will include new, integrated met
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hybrid actuator testing system' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

All transportation systems, including aircraft, suffer from fatigue failures. To ensure that components and systems reach their target life times durability testing is carried out. The generation of very high forcing levels required, at both low and high frequencies currently requires complex and expensive equipment. The choices open to a company needing to test is between; electromagnetic shakers and servo hydraulic actuators. In both cases the costs involved are high and more importantly the performances are always compromised.The impact on the environment through the use of these systems is typically high as they invariably use large electronic amplifiers or hydraulic plant that consumes 100's of kW of power. The HATS system will use the SMART material TERFENOL-D to produce a composite actuator. The actuator will comprise a low frequency hydraulic ram and high frequency Magnetstrictive force actuator aligned in series.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enhancing the innovation management capacity of the SMEs in Central Poland-2', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The KAM2CentralPoland-2 project will be implemented by the consortium called EEN-CP in central parts of Poland. The main objective of the project is to increase the efficiency and the effectiveness of R&D and innovation investments that will contribute to smart growth in EU countries. Main objective of the project will be implemented via two specific objectives: 1.To provide higher quality innovation support services to small and medium enterprises where those are absent or offered at unaffordable market prices. This objective will be implemented by a specially designed activity called Enhancing the innovation management capacity of SMEs (EIMC), addressed to SMEs with a real potential for international growth via product, process, service or business model innovation but lack the knowledge, skills or ability to manage innovation activities; 2.To ensure that the SME Instrument beneficiaries receive the most appropriate services to enhance the probability of successful exploitation of the innovation project supported by the Instrument and to leave a footprint for the future sustainable growth of the beneficiary by identifying bottlenecks and indicated solutions with the help of a capable coach. This objective will be implemented by the tailor made service of The Key Account Management (KAM). There are measures within the structural funds dedicated to the SME sector that support elements of innovation management but the mentoring and coaching schemes still needs to be improved. Thus, both services the KAM and the EIMC offered under this proposal address the challenges described in the Article 10 of the COSME regulation as well as it meets the requirements of the specific activities in the context of innovation support described in the Terms of Reference of the Consultation