RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Horse Power: Interactions between China, Mongolia and the steppe 2000-0 BCE'.

assistant: **Concept**

Horse Power will examine the complex interactions between the eastern steppe and China from the second millennium BCE to the formation of the Xiongnu empire in Mongolia and the Qin state in China after 300 BCE. From the second millennium BCE two great worlds formed, traded and fought across Eurasia. From Mongolia to the European steppe great horse and herding cultures coalesced across thousands of kilometres of grassland. To the south, a string of states existed from Egypt to the Chinese Central Plains, some already ancient and others newly created. Interaction between these worlds was constant and profoundly formative for all parties, a fact we are only starting to fully appreciate. To examine the connections between the steppe, Mongolia and Chinas Central Plains we will combine the latest scientific techniques in genetics and metallurgical analysis with theory concerning politics and power within and between China and its northern neighbours. Three principal empirical elements underpin the project: ancient DNA from horses; the characterization of bronzes to throw light on their movement and recycling; the structure and contents of archaeological sites (mainly graves) in China, Mongolia and the steppe. We will develop theory on the nature of leadership and power, particularly in mobile societies. Science will meet social science in a mutually informative manner and we will work across linguistic boundaries (Chinese, Mongolian, Russian, English) in a spirit of the co-production of knowledge with important partners including The Emperor Qin Shihuangs Mausoleum Site Museum in China and Mongolian universities. We will reflect on our working practices, engaging a broader public in how a complex research project works. An innovative artistic programme will engage a range of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Computer-Optimised Pulmonary delivery in Humans of Inhaled Therapies' (COPHIT).

assistant: **Innovation**

An HPC simulation of the human respiratory system will be developed, capable of predicting the final deposition site of inhaled materials (particulates, aerosols and gases), and their uptake into the body. Combining elements of compartmental and Computational Fluid Dynamics code seamlessly, it will include a model of a drug delivery system. Initially intended for the pharmaceutical and medical device industry (because of the upsurge in the development of drugs for inhalation), the model is directly applicable to other major industrial sectors and regulatory authorities. The model will be validated directly against human deposition trials using dynamic MR imaging of therapeutic and diagnostic drugs administered by a new high-precision pulse system. Over 25% of European citizens are affected by medical conditions (asthma, diabetes, heart failure and others) for which inhaled therapies are being developed.Objectives:1. To integrate one-dimensional compartmental models with three-dimensional computational fluid dynamics (CFD) to produce a comprehensive simulation tool for the study of delivery and uptake of pharmaceutical and therapeutic agents by inhalation;2. To develop and to implement within a commercial CFD program appropriate Lagrangean tracking algorithms for gaseous, particulate and aerosolised agents in transient flows;3. To produce high-resolution geometrical and computational models of the bronchial and pulmonary trees using state-of-the-art medical imaging modalities;4. To test the software in the context of pharmaceutical control of pulmonary hypertension using two diverse agents, one gaseous and one aerosolised;5. To test the software on high-performance and distributed computational platforms.Work description:This proposal brings together a consortium of simu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Microstructural Design of Bulk Ultra-fine Grained and Nanostructured Materials for High Performance Applications' under Seventh Framework.

assistant: **Concept**

Bulk ultra-fine grained (UFG) and nanostructured (NS) materials have attracted immense interest in recent years due to the paramount goal of achieving simultaneous increase in strength and ductility. A unique method for obtaining these materials is the utilization of severe plastic deformation for structural refinement. Despite their technological importance in industries ranging from automotive and aerospace to energy and biomedical; efforts on difficult-to-work hexagonal close packed (hcp) materials have been comparably limited in quantity and scope.Robust utilization of UFG-NS materials in engineering applications will not be possible without exploring the mechanical behavior within given operation envelopes, typically not limited to ambient or monotonic conditions. This project aims to investigate the monotonic-cyclic response of severely deformed hcp materials by exhibiting the interplay of unique deformation mechanisms at the micro-nano scale, and strengthen the understanding of their effects on the observed mechanical behavior. With the aid of novel characterization techniques, trends in the processing-structure-property relations among the model materials will be demonstrated. These will be incorporated in physically sound constitutive models for improving the predictive capabilities. Ultimately, these efforts will fill in the crucial missing gap between engineered microstructures and envisaged applications for European competitiveness and welfare.Over the last decade, the PI has experienced with multiple projects in quest for fabricating, characterizing and modeling high performance advanced materials. The current proposal facilitates bringing this expertise on the processing intricacies, characterization techniques, plasticity modeling and applications of seve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Circadian structural transitions of chromatin' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Transcription factors (TFs) distinctly mark regions of the genome for expression and are the pillars of cell identity. Yet, even at the basic level of DNA recognition by TFs, we know very little about how this is achieved. In eukaryotes, all DNA-templated processes occur in chromatin; however, most studies elucidating the molecular mechanisms of transcription have been performed on histone-free DNA. In the proposed project, we will use TFs as centerpieces to understand how, in the circadian system, the interplay between transcriptional regulatory complexes and chromatin shapes the eukaryotic genome to control gene expression. Specifically, we will use biochemical approaches paired with functional genomics and cryo-EM (single particle and tomography) to investigate how histone identity affects TF-DNA engagement and how TFs and histone modifications influence chromatin organization across biological scales, from nucleotide sequence to chromatin structure in situ. We will exploit circadian time in mammalian cells and the unicellular green algae, Chlamydomonas to elucidate the dynamic gene regulation of a biological system under natural conditions. Using diverse model organisms will enable us to reveal common, conserved properties and processes. Ultimately, these studies will provide unique insight into the fundamental mechanisms of gene regulation while dissecting the molecular mechanisms of biological timekeeping.


**Keywords:** chromatin, transcription factors, cryo-EM, circadian
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Causal Argumentative Learning Assistant' (CArLA) under Horizon Europe.

assistant: **Objectives**

Causal AI is widely perceived as crucial in the current AI landscape as it allows capturing causal effects amongst features in data, rather than simple correlations. Causal discovery is an important aspect of machine learning as it paves the way towards achieving Causal AI. It amounts to extracting causal graphs from data, encoding the structure of causal relations amongst features in data. There is a gap in the state-of-the-art in AI as concerns causal discovery, in that most approaches are black-boxes, hard to understand and explain, and unable to engage domain experts to integrate and possibly contest the learnt graphs when they are misaligned with human knowledge and values.  CArLA aims at developing a platform for transparent, explainable, interactive  and contestable causal discovery, based upon an existing principled methodology and prototype, as well as XAI techniques,  developed within the ERC Advanced ADIX project. CArLA’s platform will support understanding the causal discovery process from data and experts while being able to influence it. Any developer or user of applications in high-stakes domains will benefit from using this uniquely trustworthy platform.  CArLA aims to develop two demonstrators of the beneficial use of the platform in the high-stakes domains of healthcare and finance, to pave the way to commercialisation with a spinout.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Encoding, Absorption and Abandonment of Cultural Material during Migration: : The Case of Judeo-Spanish Songbooks' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Since the 18th century throughout the Mediterranean basin Judeo-Spanish men and women have notated songs they want to remember in personal songbooks. Both Oriental (Ottoman Empire) and Occidental (North Africa & Gibraltar) Judeo-Spanish communities still have an enormous sung repertoire which plays a core function as identity marker. It is also centrally positioned for symbolic roles and gender negotiations. Historically, this repertoire was notated in songbooks which were created both for personal use or for transmission to their descendants. The porousness of repertoire found within these private books which function as objects of orality demonstrate the continued absorption and interpenetration of languages and cultural references during various centuries. Songbooks served as cultural reminders of the layered identities that Judeo-Spanish speakers sought to preserve. While keeping traditional repertoire, the writers of these songbooks simultaneously absorbed important musical elements from their surroundings, demonstrating a multiplicity of cultural codes that coexist dynamically. This continual construction of their seemingly opposing roles as preservers and innovators of repertoire breaks all attempts at strict regionalism, while ensuring that certain traditional specificities remain untouched and unchanged. The scholarship on these songbooks and their content has only been done on an individual basis, focusing on philology or ethnomusicological issues regarding contrafacta. This ground-breaking proposed study will analyze the individual songbooks as parts of a larger pan-Mediterranean corpus of Judeo-Spanish songbooks which negotiate identity transmission in an inclusive manner absorbing elements of the surrounding cultures while protecting the boundaries of the g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Bioinformatics network for agents researchers' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

The Agents Group of the University of Edinburgh conducts research on agents and multiagent systems, in particular multiagent learning, agent interaction and communication and agent-oriented software engineering. Its research focuses on three key aspects of intelligent agents and multiagent systems: Dealing with agent autonomy, learning to communicate and engineering open systems. MicroArt is a partner of eTumour project and has the responsibility of applying Agents into the distributed system for brain tumour diagnosis.Mariola Mier and Xavier Rafael, who work in MicroArt, are the persons who would stay for a year in the Agent Group of the University of Edinburgh, in order to boost their knowledge of Agents technology. Moreover, MicroArt leads a project proposal (HealthAgents) already sent to the European Commission for extend the Agent functionalities of eTumour project. Although the University of Edinburgh had no relation to eTumour, in this new proposal, was invited and is a partner of the team. An objective of this project is also to start the collaboration between MicroArt and the University of Edinburgh.Mariola Mier and Xavier Rafael from MicroArt would follow a MSc research supervised by Michael Rovatsos , whom research topic focuses on multiagent systems and distributed Artificial Intelligence. Since September 2004 he is a lecturer at the Centre For Intelligent Systems and their Applications of the School of Informatics at The University of Edinburgh, Scotland, UK.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'paINTed mEtal aRteFActs ConsErvation' in the context of a Horizon 2020 call.

assistant: **Objectives**

The use of science for the conservation of cultural heritage is nowadays widespread. Many studies have been conducted on artworks made of single materials (e.g. paintings, stones, metals). However, a novel research field is rising among European conservation scientists: the characterisation and conservation of composite artefacts. This project will be focused on composite artworks made of painted metal. Indeed, the particular use of metals as “canvas” has never been investigated even though many masterpieces were created using this technique. Known are the degradation mechanisms occurring to metal artefacts as well as to paints as single materials. However, rare studies about painted metals and paint-metal interactions have been undertaken so far. Indeed, there is an extended lack of knowledge about the degradation processes that occur on such artefacts and about the conservation methodology to adopt. The project INTERFACE (paINTed mEtal aRteFActs ConsErvation) aims to fill this lack of scientific information, having two main objectives:1. The characterisation of the degradation mechanisms, with particular attention to the processes occurring at the paint-metal interface;2. The development of a conservation methodology to preserve both paint film and metal substrate.In particular, the decay mechanisms and the conservation approaches of copper and iron/low carbon steel as substrates decorated with linseed oil paints and lacquers will be investigated. The first phase of the project will focus its attention on the permeation of the paint film, on the metal corrosion processes (e.g. differential aeration, cathodic delamination) and on the interaction between the binder fatty acids and the metal substrate at their interface. For the first time the interface area between the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Precision climate resilience for agriculture and forestry sectors in the European boreal regions' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Climate change affects Boreal regions and their communities severely as these areas are warming three times faster than the global average. Primary producers, such as farmers and forest owners (actors), face a significant challenge when it comes to adapting to these changing conditions. They need tested, proven solutions to help them adapt and so become a resilient primary production sector. We need to bridge the gap between science, which has the knowledge and solutions, and targeted practical implementation with local actors who will use them. Precilience therefore applies an inclusive and collaborative approach to test and demonstrate various solutions for increasing climate resilience in the EU Boreal region. The most effective measures are tailored to their location. We will collaborate regionally, including with authorities, to find the most relevant risks and suitable nature-based solutions. Together, we will co-create the most impactful adaptation portfolios for changing conditions in the agriculture and forestry sectors of 11 focal regions in Denmark, Estonia, Finland, Norway and Sweden. 4 replicating regions will also benefit from the lessons learned and demonstrated solutions (DK,FI,NO,SE). We demonstrate hands-on solutions with local actors under 8 themed demonstrations: a) Co-create adaptation strategies; b) Diversify agricultural production; c) Sustainable water management and recycling; d) Soil function enhancement by closer-to-nature management and improvers; f) Assess vulnerable forest types; g) Innovative forest regeneration in drought-prone sites; h) Closer-to-nature forest management; i) Use climate-considerate tree material to replant forests.  We work with local stakeholders to further develop certain demonstrations. This involves targeted collabor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Vaccination In Atherosclerosis' under Seventh Framework.

assistant: **Concept**

Cardiovascular disease (CVD) is still a leading cause of death in the European Union (EU) accounting for nearly half of all deaths in Europe (48%). In addition, CVD complications lead to a vast number of hospitalizations and thus to a great burden of health care costs in the EU. Atherosclerosis and its final complication, plaque rupture and subsequent infarct in heart or brain, is the main underlying pathology of CVD and atherosclerosis is responsible for 70% of all cases of CVD. Extensive studies into the pathology of atherosclerosis show that its etiology is found in a combination of dyslipidemia and a related inflammatory response with an established autoimmune component, while the major cause of acute CVD events, plaque rupture, due to an inflammatory destabilization of the atherosclerotic lesion. CVD is therefore an autoimmune-like disease in the context of a metabolic disease. Thus far, therapeutic approaches in CVD have been focused at normalizing dyslipidemia in order to lower plasma cholesterol. Statins and additional surgical approaches such as angioplasty have achieved a 30% risk reduction for CVD during the last 10-15 years. However, additional approaches to improve the treatment of dyslipidemia by for instance improving the level of the anti-atherogenic lipoprotein HDL have failed in a number of clinical trials. This implicates that new therapeutic approaches are urgently needed to narrow down the remaining 70% risk for CVD. We aim to develop a new immunomodulatory treatment, a therapeutic vaccine that permanently restores the immune balance within the arterial wall by inhibiting the inflammatory responses during atherosclerosis. The VIA consortium aims to develop a vaccine, dissect the immune pathways underlying the beneficial effect of the vaccine, optimi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dynamic axial chirality of tertiary aromatic amides, applications in asymmetric synthesis' (DYNAMAX).

assistant: **Concept**

A few years ago, the host laboratory has started a new project based on Memory of Chirality and dynamic axial chirality of tertiary aromatic amides and developed a new asymmetric synthesis of quaternary alpha-amino acids by using only the chirality of starting tertiary alpha-amino acid. The host laboratory is also currently working on the development of a new synthesis of enantioenriched non proteinogenic tertiary alpha-amino acid starting from achiral compounds (glycine and aromatic acid) and based on frozen chirality. The good results obtained encouraged them to pursue in this field. The current project consists in further extensions of these methodologies. This project is a great challenge because  it is very original in terms of asymmetric synthesis, and in case of success, it would lead to the achievement of absolute asymmetric synthesis of tertiary alpha-amino acids.First, the projects plans to modify the substrates (to improve if possible the results) and then to extend these methodologies to other electrophiles in order to obtain functionalized quaternary or tertiary alpha-amino acids by aldolisation and conjugate addition. Another extension would be the application to the asymmetric synthesis of biologically active compounds, sphingophungines .  Finally, the project plans to use the host laboratory expertise in the synthesis of oxazolidinone with external axial chirality to produce new chiral ligands and use them in asymmetric catalysis.