RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'NeuroClues: the clinical must-have for Neurologists: clinical validation, industrialization, and go-to-market.' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

P3Lab developed NeuroClues, a first-of-a-kind portable, fast and easy to use eye tracking medical device that brings clinically validated eye movement biomarkers for movement disorders (MDs) into the clinical routine of neurologists. NeuroClues will enable neurologists to establish their MD diagnosis faster (from months to days) earlier and more reliably, and with diagnostic grade accuracy. This will enable neurologists to start patient care earlier. This project aims at validating and demonstrating (I) the usability of NeuroClues in the clinical routine with early adopter KOL neurologists and (II) assess its clinical value in ongoing and (III) in own sponsored clinical investigation studies (EU and US). This is needed to convince the broad majority of neurologist of NeuroClues’ clinical value. The successful demonstration and accompanied development of our go-to-market strategy will enable P3Lab to become investor ready by 2024 and profitable by 2027, with €70M ARR targeted by 2030.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enforcement of T-cell quiescence by Schlafen2' under Seventh Framework.

assistant: **Concept**

The immune system maintains a vast repertoire of lymphocytes waiting to respond to microbial invasion. These cells are kept in a quiescent state, characterized by arrest in G0 and a decrease in cell size and metabolic activity, until they are activated. Not long ago, quiescence was considered equivalent to “absence of activation”, namely a default state of the cell. Recently our discovery of a chemically induced mutation, elektra, enabled us to illustrate what happens when quiescence fails. Elektra mice showed an abnormally high frequency of T-cells in a semi-activated state and suffered from immunodeficiency. We ascribed the elektra phenotype to a mutation in Slfn2, a gene of previously unknown function, and concluded that SLFN2 plays an essential role in immune defense, where it operates to maintain quiescence in T-cells and monocytes. Moreover, our results demonstrate that quiescence programming must be actively maintained.  However, lymphocyte quiescence is still poorly understood and the mechanism by which SLFN2 maintains it is also unknown. We now propose to use molecular approaches combined with unbiased forward genetic screening to elucidate mechanisms by which SLFN2 enforces T-cell quiescence. Specifically, we will: 1) identify SLFN2 binding partners and investigate the nature of the interactions; 2) elucidate key molecular processes in T-cells regulated by SLFN2 by a forward genetic screen. These findings will likely have relevance to other immune cell populations which are not T-cells and may also clarify the function of other members of the SLFN family. The identification of lymphocyte quiescence maintaining factors will integrate to understand how the immune system is able to defend the host while maintaining self tolerance and therefore have the potential
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'INCREASED VIRGIN OLIVE OIL YIELD AND QUALITY BY COMPLEMENTING EXISTING AND NEW OLIVE OIL MILLS WITH PULSED ELECTRIC FIELD (PEF) TECHNOLOGY'.

assistant: **Objectives**

Olive oil is a key product of the European agro-alimentary sector, and is increasingly recognised by consumers worldwide as part of a healthy diet due to its elevated oleic acid content, and antioxidant properties. Around 2 million tonnes of olive oil are produced each year in the EU by mainly SME olive producers, cooperatives, mills, refiners, blenders, and distributors, employing some 800,000 people. The EU is world’s major olive oil producer and consumer, but faces increased competition from non-EU Mediterranean and other countries including Argentina, Mexico, South Africa, Australia, and the USA, which have large extensions of land suited to high-density cultivation of olives. Olives contain around 17-26% by weight of oil. Virgin olive oil production involves crushing of the olives and separation of the oil from the solid matter and vegetable water, however, current processes suffer from limitations in olive oil yield and quality, and energy usage. OILPULSE will overcome such limitations by complementing existing and new mill equipment with pulsed electric field (PEF) technology - an emerging food technology, which can be used to improve process yield as a less energy and time consuming alternative to thermal or enzymatic treatment. It is being applied to a wide range of food products at pilot plant scale and also for non-thermal commercial food preservation whilst retaining fresh food characteristics. The expected benefits of OILPULSE are: •Increased virgin olive oil yield •Increased virgin olive oil phytonutrient content, to improve consumer health benefits and olive oil shelf life. •Reduction of olive paste temperature during processing, to provide energy savings, and improved oil quality whilst retaining yield. The benefits of the novel OILPULSE technology could
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Law, Authority and Learning in Imami Shi'ite Islam' to be submitted under Horizon 2020.

assistant: **Abstract**

The academic study of Islamic law has, so far, almost exclusively focused on Sunni legal thought. The legal thought and practice of Shi’ite (and other) traditions has been neglected, and this has created a rather skewed account of the history of Islamic law. This project aims to rectify this inadequacy by producing a body of research in which the Imami Shi’ite contribution to Islamic legal history is described, analysed and evaluated. Imami Shi’ites, sometimes termed Twelvers, are the largest branch of Shi’ism today. Imamis form a majority in Iran and Iraq where the major Shi’i centres of legal learning are located.In the project, we aim to examine the theories and methods used by scholars in the study of Islamic law, derived mainly from Sunni sources, and test them against the Shi’ite legal literature. The project aims to demonstrate that a non-Sunni tradition of Islamic legal thought, in this case Imami Shi’i law, can illuminate and enrich the general history of Islamic law. At times, Shi'ite law shares features with other legal schools; at other times it provides an alternative account, challenging long held assumptions concerning Islam’s legal development. The project will do this through 5 independent, but linked, Research Themes, in which research fellows and visiting professors will carry out detailed programmes of research. These will cover  Imami law and doctrine, the dynamics of legal authority, the relationship between legal theory and doctrine and the influence of law on political theory.  The project will facilitate opportunities to test the researchers' research findings with both international experts in the field, and scholars from within the Imami legal tradition.The Principal Investigator, Robert Gleave, has made a major contribution to this area in hi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Physically unclonable functions found in standard PC components'.

assistant: **Innovation**

Physically Unclonable Functions (PUFs) are used to uniquely identify electronic components and to protect valuable objects against counterfeiting. They allow creating a root of trust in a hardware system through generating device-unique fingerprints" and deriving secret keys from the underlying physical properties of the silicon. Today they are typically found in specially designed hardware components and result from the silicon properties of individual transistors. They exist in many forms, among which are the so-called SRAM PUFs.<br/>This project intends to study and show the existence of SRAM PUFs and other types of PUFs in standard PCs, laptops, mobile phones and consumer electronics. This has not been attempted so far. The mere existence of physical properties that depend on a component and are reproducible is only the first step to guarantee appropriate robustness, reliability and randomness properties for use as secret keys or trust anchors in mass-market applications. By uncovering the security properties of PUFs in standard components such as graphical processing units, central processing units and PCI connectors, this project will provide the first intrinsic and long-wanted basis for security in everyone's most common computing platforms: standard PCs and similar hardware. This new root of trust in turn adds security for mass-market applications, replacing or complementing the role of a trusted platform module and enabling security for applications such as broadcast applications, content protection for the gaming industry and secure day-to-day transactions for everyone. The results of the project will allow for the first time an a priori open platform, the most difficult element to secure in an information-technology system today, to inherit security propertie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanisms and biological functions of H3K27me3 reprogramming in plant microspores', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

How totipotency is established in germ cells is an essential question in reproductive biology. In the plant male germline, the haploid meiotic products  microspores  are totipotent, which permits crop breeding via microspore embryogenesis. However, the molecular basis and biological significance of microspore totipotency are unknown. More generally, our understanding of plant cell totipotency is in its infancy. My lab established the Arabidopsis male germline as a model to study germline epigenetic reprogramming. We recently discovered that H3K27me3, a histone modification essential for developmental regulation, is globally erased in microspores. We also identified a new family of histone H2A deubiquitinases (GDUs), and our results suggest that the GDUs and a histone H3 variant (H3.15) gradually remove H3K27me3 during microspore development. I hypothesize that global H3K27me3 erasure facilitates the diploid to haploid transcriptional shift, establishes cellular totipotency, and allows the two identical sperm cells within a pollen grain to initiate the development of distinct seed structures (embryo and endosperm).  We will leverage our recent discoveries, as well as state-of-the-art technologies, to study in-depth the epigenetic basis of microspore totipotency and its biological functions, via these aims: 1) determine the timing, scope and functions of H3K27me3 reprogramming in microspores; 2) understand the role of histone H3.15 and GDUs in H3K27me3 reprogramming; 3) alter microspore regeneration ability by manipulating H3K27me3 reprogramming;  4) elucidate the contribution of global H3K27me3 erasure to double fertilization. Our outputs will revolutionize our understanding of plant cellular totipotency and sexual reproduction, and elucidate novel strategies to enhance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Human-Tech Nexus - Building a Safe Haven to cope with Climate Extremes' (2021-2027).

assistant: **Concept**

The HuT will employ innovative disaster risk reduction solutions, accounting for the potential variations induced by climate change. This will involve integrating and leveraging best practices and successful multi-disciplinary experiences that have been recently developed within various territorial contexts by leading European research groups, institutions, and stakeholders, to deal with extreme climate events. The project’s main ambition beyond the state of the art is to promote the “best set” of trans-disciplinary risk management tools and approaches that could be adopted and used extensively across Europe, in as many situations as possible. The activities of the project will be developed considering the following main critical dimensions: trans-disciplinarity, systemic risk, co-production, cross-fertilization, transferability, and long-term legacy.A set of ten demonstrators will constitute a multi-hazard arena wherein possible disastrous events associated with climate extremes will be dealt with jointly by representatives of the scientific and technical communities, practitioners, policy-makers and local communities. The events associated to climate extremes that will be considered in this project are: forest fires, including wildland urban interface fires; meteorological/hydrological/agricultural droughts, including associated water shortage; heatwaves; weather-induced landslides, including debris flows; fluvial and pluvial floods; storms, including heavy rain, hail, thunderstorms, and storm surges. The HuT will mainly focus on the prevention and preparedness phases of the disaster risk management cycle, explicitly considering climate change scenarios and integrating the proposed set of solutions, for the various events considered, over short- (from days to several
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'STARs that 'R' Young : When do stars form in clustered environments?' (STARRY) under Horizon 2020.

assistant: **Objectives**

STARRY (STARs that ‘R’ Young) is a twin site EID that will provide training to 2 inexperienced researchers in the development of sophisticated research tools in order to exploit, interpret and analyse astronomical data from state-of-the-art observatories in the field of star formation. The joint training programme is provided by world experts in stellar astrophysics at the University of Leeds, UK and in developing, maintaining and exploiting space science data archives at ISDEFE in Madrid, Spain.The programme is extremely timely in exploiting the astrophysical data that are now becoming available from the European Space Agency’s (ESA) mission GAIA and other, mainly European-led, sky surveys.  These new developments allow us to answer a current and significant question in the field of the formation of stars, namely: “do massive stars form in clusters?”. The science question requires a particular, novel, functionality to interpret and analyze these new data, and the programme brings together both the academic sector and the non-academic sector to achieve this.  The tools which will be developed in the Work Packages in order to address the current scientific question have the potential to enable future studies in many branches of stellar astrophysics, and beyond. Throughout, emphasis is put on skilling a new generation of researchers to work and communicate cross-borders which is vital for the future competitive health of this sector. In short, the need for the development of new analysis tools is identified by a clear and current research question. Its implementation will have a long term benefit to ISDEFE which will ultimately lead to a competitive commercial advantage for the company across Europe. In addition, a new generation of researchers is provided with a research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'DIgitised European PERiodicals'.

assistant: **Objectives**

DIEPER will offer the test-bed for studying the impact of providing electronic access on the use of back issues of research periodicals and may pave the way for electronic modes of publication.After the end of EU support of the project the infrastructure set up by DIEPER shall remain intact. A model for its financial viabilitiy will be drafted within the project phase to enable starting with a permanent service without delay.Technical approachDIEPER addresses the need in Europe for a central access point where all digitised periodicals shall be recorded. This shall be devised as a register built on the model of the European Register of Microform Masters and shall take into account JSTOR, which provides similar service to American users. Records of the register will be linked to reliable and comprehensive archives of periodical literature working at different sites thoughout Europe. Those archives will of course be equally accessible from other points (e.g. WWW pages and bibliographic databases) but the register will be the only place, where it is attempted to file all the relevant records. In addition a search engine accessible from the register will allow to do a fulltext search of the articles in digitised periodicals or at least a fulltext search of the tables of contents.The project participants will contribute to building a virtual library of periodicals by scanning a few journals according to de facto standards and to demonstrate the technical feasability of optimum online access and retrievability. At the same time they will make accessible any already existing digitised periodical by including its record in the register and by linking the search engine to it. In establishing this infrastructure it is hoped to develop a uniform strategy for retrodigitising throug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Evaluation of risks and monitoring of nitrogen and pesticides fluxes at the crop level under Romanian and Bulgarian Danubian plain situation' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Foreseen ResultsFurthermore, an objective of this projects is also to maintain in Romania and Bulgaria the R&D potential in relation with the considered topic Supply and operation of the tool 'modelling of farming impacts on the environment'". Indeed, the experience of the INRA and of the Agronomic Sciences Faculty of Gembloux in this field should ensure simultaneously the training or the perfecting of the Eastern and Central Europe countries' researchers and the development of recommendations and environmental-friendly agricultural practices, directly applicable by the farmer.The European Community countries' ecological experience has emphasized the necessity of anticipating all environmental problems, notably regarding non-point source pollutions from agriculture in large-scale farming industry. The nitrates and pesticides fluxes linked to agricultural productions, and their impact on drinking water quality and on water ecosystem justify that actions be launched in such zones as the Bulgarian and Rumanian plains, which constitute the Danube's watershed, with the Black Sea as outlet.Firstly, the study of "typical" situations, that is to say the most common crops and soils, will allow an estimation of the risk level in order to define the means to reduce nitrate and pesticides percolation downwards deep ground water and/or rivers.The modelling of the Soil-Plant System will be used in this analysis. In that view, a first series of experiments will be performed to calibrate the model parameters. The in situ model validation will have two parts : i) a specific series of experiments and ii) a secondary validation will be performed with already available data.From these models, both a risk evaluation and an identification of sensitive zones will be done in relation with the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The circadian and developmental regulation of melatonin synthesis in the pineal gland of the zebra fish' (1994-1998).

assistant: **Innovation**

Research objectives and content  The cellular events which regulate melatonin synthesis in the pineal gland are not well understood. N-acetyltransferase (NAT) is the enzyme responsible for the synthesis of melatonin, and is under the control of a circadian pacemaker in the pineal gland of many vertebrates. The pineal gland of the Zebra fish contains an endogenous circadian pacemaker. I propose to study the circadian transcriptional regulation of NAT activation; which transcription factors and kinases are responsible for the nocturnal increase in NAT transcription. Also the development of the circadian system in the Zebra fish embryo will be examined, as well as the embryonic target tissues of this hormone. Training content (objective, benefit and expected impact)  As part of this project I wil receive training in a range of molecular techniques available in the laboratory of Dr Sassone Corsi. In addition developmental techniques and the use of the Zebra fish as a model system will be learned. This basic research will have considerable impact on our understanding of melatonin synthesis and function: important information considering the current siqnificance and use of this hormone.