RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Heat transfer and friction between two closely spaced objects due to phonon transfer across a vacuum gap' (PhononGap), addressing dissemination and exploitation.

assistant: **Impact**

Phonons (collective atomic vibrations in solids) are more effective in transporting heat than photons. This is the reason why the conduction mode of heat transport in solids (via phonons) is dominant compared to the radiation mode of heat transport (via photons). However, since phonons are unable to traverse a vacuum gap (unlike photons) it is commonly believed that two bodies separated by a gap cannot exchange heat via phonons. Recently it has been recognized that a mechanism could exist where phonons can transport heat across a vacuum gap - through Van der Waals interaction between two closely separated bodies. Important recent experimental measurements have indeed confirmed that photon-mediated heat transport cannot be the only source of heat transport between two objects with small spacing, thus leaving open a fundamental question over what other sources of heat transport can exist. The first aim of this project is to theoretically estimate the heat transport mediated by phonons transmitting across a vacuum gap via the Van der Waals force.Closely spaced bodies can not only exchange energy resulting in heat transfer but also momentum which results in frictional forces. There is no one single theory that explains the origin of friction; indeed there can be many sources. Considering the importance of friction, especially to the micro-electromechanical industry, it is important that each of the sources is identified and quantified, and the situations when each mechanism can dominate is understood. One known form of friction is Van der Waals friction where photon exchange between surfaces result in friction due to the Doppler effect. Likewise it is possible for Doppler-shifted phonons to contribute to friction when they transmit across a vacuum gap via the Van der Waals
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Electrochemically induced Asymmetry: from materials to molecules and back' in the context of a Horizon 2020 call.

assistant: **Objectives**

Asymmetry is a very common feature of many systems, objects and molecules, that we use in our daily life. Actually, it is in a majority of cases the absolutely crucial ingredient for conferring a useful property to a system, a prominent example being the chiral nature of pharmaceutically active compounds. Chemists have developed various approaches to generate asymmetry, from the molecular to the macroscopic scale, but are still facing major challenges when exploring efficient alternative physico-chemical concepts for symmetry breaking. The global aim of ELECTRA is to propose so far unexplored and versatile strategies, based on the unconventional use of electrochemical phenomena, to generate asymmetry in chemical systems at different length scales.Investigating simultaneously wired and wireless electrochemistry will open up unique possibilities for advancing the topic of asymmetry generation in an original and cross-disciplinary way. We will determine the utility of these strategies in the frame of two major challenges that are: -unconventional detection, separation and synthesis of enantiomers, based on chiral encoded metal phases, very recently pioneered by us; -design and characterization of Janus systems with complex structures and reactivity Carefully designed experiments at the forefront of electrochemical science will first enable us to gain a better understanding of the different mechanisms involved in symmetry breaking. An optimization by exploring new concepts with respect to their efficiency, yield and selectivity is the next step. This will prepare for the choice of the most innovative approaches of symmetry breaking, in view of the numerous highly relevant applications, ranging from analysis to catalysis and energy conversion. Furthermore, due to the interdi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Effects of global warming and alien species invasions on high diverse communities of NW Mediterranean Sea' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Climate change and alien species invasions are leading to significant diversity loss and affect ecosystem functioning worldwide. In the NW Mediterranean the occurrence of unprecedented mass mortality events have been related to strong positive temperature anomalies possibly linked to climate change. On the other hand, in the Mediterranean there is an increasing number of invasive species. Up to now, most studies focus only on the effects of single disturbance source, although the potential combined effects of different disturbances are raising concern. This project will examine the direct and potential combined effects of climate change and the invasion of an algal species in the Mediterranean coralligenous. Coralligenous community is the richest one in terms of both species and organization among the Mediterranean benthic communities. It harbours great number of endangered species, long-lived organisms, very sensitive to strong disturbances. Among them, calcareous sciaphilic algae provide the structure of the community and gorgonians provide erect substrata like trees in the terrestrial forests. Gorgonians were severely affected by recent mass mortality events, but although the paramount role of calcareous algae on the structure and organization of coralligenous community we lack of quantitative information on mortality and noxious effects of positive temperature anomalies for these species. Conversely, the actual spreading of an invasive algae species may be causing strong impacts in the community and could be a major threat for the recovery process for species that have already suffered of mass mortalities due to global warming. This project will focus on 1) the factors that may favor invasion of alien species in coralligenous communities, 2) the response of calcareo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A novel, fast oscillating rotaxane fixed on a gold surface' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Molecular machines and motors are meanwhile a field of steadily growing interest. The development of molecular structures, which may perform real functions, would mean a breakthrough in miniaturisation, because the molecules are by far smaller than the components used in devices today. In my project, a very promising path is followed, consequently joining several well-founded ideas. Most former systems of rotating/oscillating molecules lacked a sufficient speed of rotation, due to their molecular structure. The target rotaxane consists of a pirouetting ring connected to an axle by a coordinated copper ion. The axle bears a central phenantroline with a modified constitution allowing much faster movement and the motion can easily be triggered electrochemically, which has been already proved by preliminary experiments. The final speed of rotation will be determined in Strasbourg. Moreover the target molecule will have two sulfide-anchors to fix the axle firmly on to a gold surface. Due to that, the deposited molecule as a whole will have no degrees of freedom, allowing strict control over the movement of the threaded ring. The preparation of a different ring carrying a long rigid group on one side, may allow visualization of the rotation by AFM (atomic force microscopy). To my knowledge, this combination of a fast oscillating, surface-fixed rotaxane, has never been used before and paves the way to other examples of molecular machines, which may finally be used in nanotechnology. The applicant joins a group with a world-class reputation. He will work closely with its permanent researchers, whose practical and theoretical experience will be valuable for his education and training. Access to the excellent facilities available at the host institution allows the applicant to in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dynamics and heterogeneity of early viral infection', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Viruses are simple replicative units built from two components: a nucleic acid and a small number of associated proteins. Upon entering a cell, viruses co-opt the hosts machineries to copy their genetic material, while shutting down the hosts antiviral immune response. The success of viral infection differs dramatically from cell to cell through poorly understood mechanisms, resulting in heterogenous propagation through tissues, and ultimately, heterogeneous disease progression.Although viruses have been studied for decades, the earliest steps of cellular infection have remained hidden, because only a few viral molecules are present at this stage, which presents formidable challenges for molecular analyses. Yet these initial events are critical for achieving a successful infection; transcription, translation and replication must be perfectly balanced to rapidly scale virus production before antiviral signalling pathways are activated. To overcome this barrier, we recently developed a first-in-kind imaging technology for simple positive-sense single stranded RNA (+ssRNA) viruses that transforms our ability to visualize early viral infection processes. In this proposal, we will expand our single–molecule toolbox to gain molecular insights into early viral infection of the more complex group of negative-sense RNA (-ssRNA) viruses. We will focus on the respiratory syncytial virus (RSV), a -ssRNA virus which can be deadly in infants and vulnerable adults, and lacks effective treatments. Specifically, we will determine i) how viral transcription and replication are coordinated on single viral genomic RNA molecules to optimize early viral propagation, ii) what causes the early viral infection heterogeneity, and iii) how heterogeneity in early viral infection impacts infection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Establishment of a European bacterial conjugate Vaccine Network'.

assistant: **Innovation**

Background: Streptococcus pneumoniae remains an important cause of morbidity and mortality in both adults and children world-wide. The increasing isolation of pneumococci resistant to penicillin and other antimicrobial agents has increased the urgency with which safe and effective methods of preventing pneumococcal infection are pursued. The poor immunogenicity of carbohydrates in those most at risk of invasive pneumococcal infections has hampered the development of an effective pneumococcal vaccine. However, the recent success of the Haemophilus influenzae type b (Hib)-protein conjugate vaccines in eradicating invasive Hib infection in children under five years of age has highlighted the success of bacterial conjugate vaccine technology. Pneumococcal polysaccharide-protein conjugate vaccines, are currently being developed by a number of vaccine manufacturers and several have entered Phase II and one, phase III studies in Europe. Problems however, surround the measurement and interpretation of pneumococcal type specific antibody titres which are used as surrogate markers of protection when evaluating the immunogenicity of pneumococcal vaccines, and large inter-laboratory variations exist. Furthermore, there is little agreement on in-vitro correlates of immunological protection for the pneumococcus and no large scale comparative studies have been performed. Objectives: This concerted action seeks to bring together laboratories currently actively engaged in pneumococcal research to: 1) optimise and quality control anti-pneumococcal type specific antibody assays across Europe and 2) compare and standardise in- vitro correlates and animal models of protection. Proposal Content: Workpackage 1 will involve the distribution of a new European secondary pneumococcal standard ser
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'High Phytosterol variants towards improved feedstocks and biofortification of crops' under Horizon 2020.

assistant: **Concept**

Phytosterols (PS) are valuable biomolecules used as nutrients and as feedstock material for the pharmaceutical and cosmetic industries. The challenge biologists and breeders are faced with is to develop bioengineering programs and valuable crops dedicated to the large-scale production of PS, which are currently extracted from agricultural waste materials. The goal of the proposal is to identify master regulators of PS biosynthesis and accumulation in plants. In fact, PS have essential cellular functions in plant growth and development, acting as key membrane components and membrane reinforcers, as signals in development and as precursors of brassinosteroids, a class of growth regulators. As such, the concentration of PS is highly regulated in order to comply with cellular homeostasis. To reach the goal, we will carry out a functional molecular characterization of a tobacco variant carrying a yet unknown semi-dominant mutation responsible for PS overproduction and  Arabidopsis thaliana mutants exhibiting a suppressor phenotype of a defect in the production of precursors of isoprenoid lipids, such as PS. The work plan is to apply advanced genomics for next-generation mapping, leading to the elucidation of mutations in genes of interest (GOI) that regulate PS accumulation. The validation of candidate GOI will be done by genome editing and the role of novel alleles in PS metabolism will be performed by various functional and metabolomic studies. Finally, the combined expression of selected GOI with steroidogenic enzymes will be assessed by implementing in folia expression assays in Nicotiana benthamiana.


**Keywords:** Phytosterols, metabolism, biosynthesis, regulation, sterol esters, genetics, genomics, crops, phytosterol market
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Role of the Gadd45 family and p38 MAPK in tumor suppression and autoimmunity' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Gadd45 family proteins play a critical role in genomic stability, cell cycle regulation proliferation and apoptosis. Gadd45a is activated by the tumor suppressor gene p53, which is mutated in >50% of human tumors. The lack of GADD45a in mice leads to spontaneous development of an autoimmune disease similar to systemic lupus erythematosus. The molecular mechanisms that cause autoimmunity are poorly understood. Recent evidence suggests that p38 activation is involved in autoimmune development and tumor suppression. We found that Gadd45a negatively regulates p38 activity in T cells by preventing phosphorylation on Tyr323. Inhibition of Tyr323p38 phosphorylation is a potential therapeutic target in several types of leukemia and autoimmune diseases, including lupus and rheumatoid arthritis. The main goals of this project are a) to study the in vivo function of the Gadd45 family and p38 in tumor suppression and autoimmunity, and b) to analyze their molecular mechanisms to identify targets for disease treatment. We will dissect the signaling pathways involved in development of autoimmunity and cancer using a multidisciplinary approach that combines mouse genetic, human epigenetic, biochemical, molecular biological and immunological techniques. Our project involves the characterization of murine models deficient in each member of the Gadd45 family (Gadd45a, Gadd45b, Gadd45g), as well as double- and triple-knockout mice, development of a knock-in model for p38a, in vivo and in vitro analysis of T cell activation, proliferation, apoptosis and differentiation, epigenetic studies of potential targets, and finally, validation of these results in autoimmune disease and cancer patients. The results of this project will help identify new therapeutic targets for autoimmune diseases and/
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Violence work: Creating and Contesting Colonial Authority on the Ground in Africa through Everyday Violence' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

VIOLENCE WORK is a groundbreaking study of everyday violence in Belgian Central Africa—Burundi, Congo, and Rwanda (19th-20th C). Though colonial violence has been studied widely, few have explored how everyday violence enabled colonialism and allowed it to persist. This project combines hitherto neglected source materials and a novel conceptual entry point—violence work(ers)—to foreground the everyday violent practices crucial to creating and maintaining the colonial state. The project’s core claim, and main innovation, is that violence work was not performed exclusively by formal violence workers—the men in uniform—but rather by a range of actors (colonizer and colonized) in- and outside the state. Everyday violence work includes not only direct acts of physical violence (e.g., whipping) but also other forms of punishment, such as incarceration and coercion through the threat of violence, as well as subtler forms of aggression forcing compliance (e.g., harassment) and the ways these different levels of violence reinforced each other. This inclusive definition enables an unprecedented, comprehensive view of the enforcement practices that colonial rule depended on. VIOLENCE WORK opens up new questions about the centrality of violence in theorizing, creating, and maintaining colonialism and the colonial state. This first in-depth, multi-sited, transnational/regional comparative study of everyday colonial violence will undergird further research on how colonial legacies persist and interact with local and new repertoires of violence work, contributing to dismantling persistent colonial myths about these regions and their inhabitants as inherently violent. The online database will be a crucial tool for future researchers and open up many new avenues of research. Its major i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Estimation of continuous time dynamic macroeconomic models under rational expectations' (1994-1998) under Fourth Framework.

assistant: **Objectives**

I will consider the maximum likelihood estimation of macroeconometric models described as systems of stochastic differential equations having the saddle path property. Deterministic versions of saddlepath stable macromodels abound in macroeconomic dynamics under rational expectations. The research project will be divided in two stages. In the first stage I will build a dynamic macromodel of complete economy, under rational expectations,based on a system of stochastic differential equations. I shall simulate the system and study its long run behaviour. In a second stage the likelihood function will be constructed based on the relevant exact discrete time model. Monetary and policy simulations will be performed. The estimation will be performed for the Greek as well as other European economies and will be implemented in the matrix programming language Gauss". "