RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The European medical isotope programme: Production of high purity isotopes by mass separation'.

assistant: **Concept**

PRISMAP - The European medical isotope programme: Production of high purity isotopes by mass separation proposes to federate a consortium of the key European intense neutron sources, isotope mass separation facilities and high-power accelerators and cyclotrons, with leading biomedical research institutes and hospitals active in the translation of the emerging radionuclides into medical diagnosis and treatment.  PRISMAP will create a single-entry point for a fragmented user community distributed amongst universities, research centres, industry and hospitals, in a similar way as the National Isotope Development Center NIDC supported by the Department of Energy (DOE) has provided radionuclide sources for users in the USA. PRISMAP brings together a consortium of 23 beneficiaries from 13 countries, one European Research Laboratory and an International Organisation. It further receives support of leading associations and institutions in the field such as the European Association of Nuclear Medicine (EANM) and the International Atomic Energy Agency (IAEA).  Our main goal is to provide a sustainable source of high purity grade new radionuclides for medicine, involving from the onset upcoming major European infrastructures, to provide a single-entry point for all researchers active in this field including SMEs, global pharma, nuclear centres, hospitals and universities, using standardised access procedures. The new isotope enrichment and standardisation techniques triggered in PRISMAP will expand our services and provide them to yet unreachable remote European laboratories. PRISMAP thus strives to create a paradigm shift in the early phase research on radiopharmaceuticals, targeted drugs for cancer – one of the major diseases in Europe - theranostics and personalised medicine, s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Circular and Dynamic Manufacturing Supply Chain Orchestration and OptimiSation'.

assistant: **Concept**

CIRCULOOS aims to deliver circular manufacturing tools which orchestrate and continuously optimise the supply-chain end-to-end and comprehensively integrate planning and execution. Combining these with direct calculation of the product sustainability and circularity profile, both internally and with external partners, this environment will enable them to configure and execute disruptive circular manufacturing processes for sustainable production that cover the entire life cycle of products which become waste and are recycled in the same or other life cycles.  To achieve this objective the project aims at deploying:Circular end-to-end supply chain orchestration of collaborative workflows and connecting planning and execution metrics with advanced and multimodal visualisation -DT of supply chains formulated, factory processes and product design- and analytics.Supply Chain Optimisation that monitors the global (across the supply chain) and local (within the factory) processes and execution.Dynamic Sustainability Assessment functionalities that ponder the alternative supply-chain scenarios (varying in terms of materials used, processing technologies, suppliers involved and/or activated circular economy practices).Supply Chain Data Spaces for seamless, multi-level data flow across the supply chain partners. Cybersecure and trustworthy data sharing across the supply chain by employing a distributed, trusted and efficient Identity and Access management system together with the associated trust framework.Novel circular business processes will be demonstrated supporting reusing, reducing, and recycling material in production and consumption systems. Skills upskilling and reskilling will be provided in RAMP and through online courses.


**Keywords:** Supply chain orchestration, S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'HUMAN AND MOUSE MODELS OF RHINOVIRUS INDUCED ACUTE ASTHMA EXACERBATIONS' (MORIAE).

assistant: **Concept**

Asthma is the most common chronic respiratory disease and in many countries prevalence continues to rise. The major cause of asthma morbidity, mortality and health care costs are acute exacerbations, with rhinovirus infection the major cause. The aim of this application is to identify novel targets for the development of new more effective therapies for treatment and prevention of virus-induced asthma exacerbations, a disease area where there is a major unmet current clinical need.   This proposal combines two unique state of the art novel models of acute exacerbations of asthma. First, a human model will be used to identify dysregulated genes/proteins and determine relationships with disease outcomes in vivo. This study will compare lower airway responses between asthmatic and control subjects undergoing rhinovirus experimental infection. This will have the dual advantage of investigating mechanisms in the most natural model possible, as well as developing a better model for testing novel therapeutic approaches. The second utilizes a unique new mouse model of rhinovirus infection in which causal relationships with disease outcomes can be investigated in vivo. This will be performed using gene-knockout mice, blocking antibodies, siRNA, pharmacologic inhibition and/or over-expression in genes in a novel mouse model of rhinovirus exacerbation.  Any genes/proteins shown to be dysregulated and related to disease outcomes in the human model, AND causally related to disease outcomes in the mouse in vivo model will be very strong candidates for immediate translation of approaches to correct the dysregulation in proof of concept pivotal human intervention studies. The development of a new low dose challenge human model proposed will also provide a new and optimal model of natur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'In praise of community: shared creativity in arts and politics in Italy (1959-1979)'.

assistant: **Concept**

INCOMMON will be the first study to systematically analyse the field of performing arts as resulting from the practice of commonality both theorized and experienced over the 1960s and the 1970s.In particular, the project is aimed to study the history of the ‘laboratory Italy’ as the place where artistic counterculture expressed by performing arts arose in a milieu characterized by a profound relation between philosophy, politics, and revolutionary practices.The overall objectives of INCOMMON are i) to study, collect and contextualize those encounters between theatre, music, visual arts, cinema and video art that assumed the form of performances, especially those created as collaborations between artists; ii) to apply the concept of ‘will-to-the-common’ to the art field of the counterculture; iii) to underline the significance of artistic communities in the local and international scene; iv) to create a digital archive of the performances of the Italian artists of the period.The project will connect historical, philosophical and artistic debates to those in other sciences, sociology and in particular Social Network Theory,in order to reveal significant structures of meanings in the artistic community and to reveal the peculiar characteristics of shared creative processes.The methodology that will be developed is meant 1) to produce new ways of modelling the knowledge and interpretation of performing arts and 2) to create an innovative form of digital archive visualization, where rich interfaces will sustain and improve the understanding of the context and relationships analysed. INCOMMON will produce a comprehensive approach, oriented toward collection, digitization, restoration  and dissemination of direct documentation and related materials of the Italian performing ar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Custom Cryptographic Solutions with Formal Security Guarantees', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Modern web applications routinely rely on standardized cryptographic protocols and algorithms to protect sensitive user data. Furthermore, with the advent of blockchains, the imminence of quantum computers, and widespread concerns about privacy in an era of surveillance and machine learning algorithms, enterprises are increasingly turning to sophisticated non-standard cryptographic solutions customized for  specific usage scenarios. Unfortunately, cryptographic design and implementation is notoriously error-prone with a long history of design flaws, implementation bugs, and high-profile attacks. This leaves software companies with a difficult choice: every time they deploy a new crypto standard or an innovative cryptographic application that improves the security and privacy of their users, they risk exposing embarrassing flaws in their design or code. The research results of ERC Circus offer a way out of this conundrum by advocating the use of formal verification to build cryptographic software with machine-checked proofs of security and correctness.  A landmark output from this project is HACL*, a verified high-performance cryptographic library which is currently used by mainstream software like Mozilla Firefox, Linux Kernel, Tezos Blockchain, and ElectionGuard. We propose to establish a company (called Cryspen) that will transition the research software developed in ERC Circus towards a production-quality ready-to-use verified cryptographic software stack. In addition, Cryspen will offer a developer-friendly verification framework that can be used to build new custom cryptographic solutions in C, Rust, and JavaScript.  The goal of this Proof-of-Concept proposal is to fund the initial technical transfer of research software to Cryspen and the business development of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Rites of Passage and Monastic Communities in the late-antique Mediterranean' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

How did medieval monastic leaders assert control over their communities? This project proposes an innovative way to approach to this often-considered question: through the rites of passage into ascetic groups in Late Antiquity (fourth-seventh centuries CE). Late-antique sources emphasise five membership rituals as particularly significant: rigorous testing; ceremonial cleansing; the offering of stability pledges; the renunciation of possessions; and the donning of uniform attire. These rites were meant to bind novices to their new lives, efface their prior identities, and enforce obligation to their abbots and abbesses. Although the scholarship on medieval monasticism is extensive, the relationship between ascetic authority structures and the aforementioned five ceremonies has received little recent substantial attention. This project proposes to investigate this relationship from the first appearance of monastic groups in the fourth century to their widespread multiplication across the Mediterranean by the seventh century. To do so, I will focus on laws, monastic rules, church canons, hagiographies, and provincial documents, five types of source which are not often brought together but represent contemporary attempts to assert control over ascetic rites of passage. My research will use a comparative, interdisciplinary framework of diachronic, transcultural and -regional, and socio-historical analysis to achieve the project’s three core goals: 1) to explore how and why these ceremonies changed; 2) to analyse how these rites supported or challenged late-antique discourses about monastic obligations and identities; and 3) to investigate how these rituals were related to other analogous rituals and processes. Furthermore, this project will contribute to the increasing scho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Attention on inattention: Dissecting the causal mechanisms of adult ADHD features' (AT-TENSION).

assistant: **Concept**

The world is witnessing a sharp rise in adult attention deficit hyperactivity disorder (ADHD) diagnoses, especially after the COVID-19 pandemic. While historically considered a childhood neurodevelopmental disorder, an increasing number of adults are now seeking help for impairing ADHD-like features like inattention, disorganization, restlessness, impulsivity, forgetfulness and emotional dysregulation. Strikingly little is known about the mechanisms causing specific adult ADHD features, raising a key question: Are adult ADHD features truly the same as childhood ADHD, or do they rather reflect other mental conditions with overlapping symptoms? Substantial phenotypic overlap of mental health conditions and lack of precise screening tools make accurate detection of adult ADHD extremely challenging and error prone. Modern mental health care critically needs advanced, biology-informed methods to differentiate mental conditions with greater accuracy.AT-TENSION combines psychology, genomics and data science to dissect the causal mechanisms underlying adult ADHD features and to propose an innovative framework for genomics-informed screening tool development. We will (i) determine diverse genetic mechanisms and causal links with other mental conditions by conducting a pioneering genome-wide investigation of specific adult ADHD features across five large biobanks; (ii) quantify the impact of diverse environmental factors like stress, lifestyle and COVID-19 pandemic on adult ADHD features across life stages and genders; (iii) develop and test a novel genomics-informed screening tool for more accurate ADHD detection in adults by using machine learning and genomics. The goals are achieved by innovatively combining three large-scale data layers: self-reported, electronic health recor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Global biological productivity during abrupt climate change' in the context of a Horizon 2020 call.

assistant: **Objectives**

Atmospheric oxygen (O2) is an essential component for life. The global biological O2 productivity has changed with Earth's climate change and, at the same time, has affected to global biosphere. Therefore, understanding how global biological O2 productivity responds to abrupt climate change is important to project future climate and environment change. However, former studies have been focused on global O2 productivity change over the glacial-interglacial transitions, mainly due to insufficient temporal resolution of existing data. This project aims to reconstruct the global primary productivity change over the Heinrich Stadial (HS). HS events are naturally occuring abrupt climate changes in the last glacial triggered by abrupt input of glacial meltwater into the North Atlantic Ocean. In this project, a new high-resolution record of triple oxygen isotopes of air O2 and COS concentrations will be produced throughout the HS events 1 to 5 using polar ice cores. Then the major controls and mechanisms will be explored by a series of sensitivity experiments using climate models with different complexities. This project will be carried out at the section of Physics of Ice, Climate and Earth at Niels Bohr Institute (PICE, University of Copenhagen). PICE equips the state of art analytical instruments and has developed the novel methods to study trace gas and isotopes in ice cores. The supervisor is a world expert of the triple oxygen isotopes of air O2 in ice cores. This project plans a secondment to Laboratory for Sciences of Climate and Environment (LSCE, University of Paris Saclay) for sensitivity experiments using climate models. LSCE is a leading institution of paleoclimate modelling, which allows a better understanding of major control mechanisms of the past productivity c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Safe System for radical improvement of road safety in low- and middle-income African countries' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The primary objective of the AfroSAFE project is to make a significant progress in propagation of the Safe System modus operandi within the road safety work context in African countries. This is reached by exposing the local practitioners and decision makers to the state-of-the-art knowledge and practices within road safety management based on Safe System principles, as well as supporting them by sharing necessary knowledge, tools and methods for road safety improvement—adjusted to the African conditions and in tight cooperation with the local actors. More specifically, this is reached through mapping of the existing regulations, procedures, methods and tools within all five pillars of road safety (management, safe infrastructure, safe vehicles, safe road users and post-crash care), development of the recommendations for improvements and running a series of pilots and demonstrations to illustrate these recommendations in action. In these activities, the problems and needs of the vulnerable road users will receive particular attention. Another focus area for the AfroSAFE project is capacity building through education of the local educators in all areas relevant for road safety. Together with them, the current curriculums are revised, new educational programmes created, and an educational platform—a virtual centre of excellence—will be created.


**Keywords:** Africa, Traffic safety, safety management, Safe System, Vision Zero
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Discovering a new family of hypermodified antimicrobial peptides from marine tunicates and exploring their potential applications', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The spread of antimicrobial resistance among human pathogenic bacteria and fungi is a major global and European concern, urgently necessitating the development of novel antibiotics. Another unsolved global healthcare problem is the burden of infections acquired through invasive medical devices. Antimicrobial peptides (AMPs) could be the solution to both problems, but they are currently limited by high cost, insufficient efficacy and stability as well as restricted chemical options for biotechnological production. However, in a group of marine animals: tunicates, there is a major, poorly characterized superfamily of AMPs with many advantageous natural chemical modifications. These unusual post-translational modifications (tryptophan bromination, arginine/lysine mono- and dihydroxylation, tyrosine hydroxylation, C-terminal amidation/oxidation) are predicted to improve potency and stability of the mature AMPs and might enable their efficient immobilization onto various surfaces. The latter property could also prove useful for surface coatings. In the current project, we aim to explore these promising bioproducts, from predictions by bioinformatics, through isolation of animal tissues, extraction and enrichment of the actual peptides, to their chemical analysis by mass spectrometry and testing of antimicrobial potency and safety. Project TuniPeps gives a major opportunity to both the applicant and host, to combine their complementary knowledge and skills in order to identify useful natural products from marine animals, acting as blueprints for future antimicrobials. These diverse molecules and their biosynthetic apparatus might also unlock cheap biotechnological production of novel molecules in the near future.


**Keywords:** Natural product discovery, Antimicrobials, Post