RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A first in category prescription regimen for ADHD combining stimulants with intelligent dosing and digital capabilities'.

assistant: **Innovation**

The goal of this project is to develop a therapy that allows for more effective management of attention-deficit hyperactivity disorder (ADHD). ADHD is a common, childhood onset, neurobehavioural disorder characterised by a combination of inattention, hyperactivity and impulsivity impairing multiple areas of life. Stimulants are the most widely used ADHD medications and are proven effective on ADHD symptoms, but classified as controlled substances they are associated with concerns about side effects and potential for abuse. In addition, they require careful dose titration at initiation and throughout the patients’ life.OnDosis aims to address these challenges by developing a novel “combination product”, prescribed as an ADHD treatment regime, that combines a technological platform with stimulant active compounds. This integrated solution will simplify dose titration, enable ease of swallowing, offer adherence support and self-monitoring checks. Importantly, OnDosis’ solution is a personalised device with the potential to reduce risk for medication abuse through tamper resistance and tamper evident features.The ultimate success of the project will depend on generation of clinical data which will support partnering and out-licensing. OnDosis plans to apply for SMEi Phase 2 grant to take the product through required clinical studies, and then go to market through a licensing agreement with a strong commercial partner. OnDosis has a strong network established with potential pharma partners and investors, and has already gained support from investors that offer strategic support to the company.The burden of ADHD is increasing and the unmet need is growing. This encourages OnDosis in the endeavour of a needs-driven research to address this widespread challenge. Market research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Harnessing Quantum Resources in Network Communication and Their Thermodynamic Underpinnings' (QURES) targeting Horizon Europe.

assistant: **Abstract**

We are currently at the midst of Second Quantum Revolution, a transformative era harnessing various quantum resources for the efficient execution of communication and computational tasks previously unattainable through classical means. During the recent past the point-to-point communication scenarios have seen extensive exploration and practical realization of quantum resource benefits across diverse quantum architectures. Within the realm of network scenario, typical communication systems involve multiple distant parties seeking to exchange information. In the present project, our primary objective is to delve into the advantageous applications of several quantum resources, including quantum superposition, quantum entanglement, quantum steering, and quantum nonlocal correlations, in the context of network communications. Our focus is particularly directed at two broad channel categories in the network scenario: the Multiple Access Channel (MAC), featuring multiple senders and a single receiver, and the Broadcasting Channel (BC), comprising one sender and multiple receivers. A fundamental goal lies in examining how distinct non-classical correlations, achieved from multipartite quantum systems, can enhance the effectiveness of the limited communication channels available to both senders and receivers. In this endeavor, we intend to uncover a deeper connection between quantum information theory and quantum thermodynamics. While the intricate link between these domains has been highlighted by the work of Szilard, Landauer, and Bennett, our aim is to explore this connection within the quantum realm to its broadest extent, with a specific focus on network communication scenarios. In addition to introducing a novel avenue for quantifying and detecting quantum resources throu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ElectroMagnetic imaging for a novel genERation of medicAL Devices' in the context of a Horizon 2020 call.

assistant: **Objectives**

EMERALD (ElectroMagnetic imaging for a novel genERation of medicAL Devices) is the coherent action of leading European engineering groups involved in electromagnetic (EM) technology for medical imaging to form a cohort of highly-skilled researchers capable of accelerating the translation of this technology “from research bench to patient bedside”. Nowadays, medical imaging technologies play a key role to face the ever-growing number of challenges due to aging populations, as they are the essential clinical tool to deliver accurate initial diagnosis and monitor the evolution of disease over time. For this reason, a whole range of new imaging modalities is currently being developed to supplement and support current modalities. Among these technologies, there is EM imaging, which involves the illumination of the portion of the body under investigation with low-power non-ionizing EM waves (in the microwave spectrum) and the use of the resultant backscattered signals to generate images of the internal structures of the body. The scientific objective pursued by the EMERALD action is to accelerate translation of research in EM medical imaging into clinical prototypes. To this end, EMERALD will establish a group of 13 outstanding early stage researchers who will be the European leaders in this field, through a unique scientific and training programme. The EMERALD trained researchers will drive the future developments of EM imaging technology, thanks to the targeted skills, they will attain, and their established connections with clinicians and stakeholders.The EMERALD consortium involves academic institutions, industrial partners, hospitals and university medical centers (as partner organizations). The success of EMERALD will ensure that all achieved innovative technological de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Researching Inequality through Science and Technology' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Recent research has established that S&T do not merely cause or alleviate inequality, but are more profoundly implicated in social relations of distribution and access. The most pervasive and obdurate sources of social distribution are enshrined and entrenched in S&T systems. This Project's objective is to understand processes that contribute to the increase in inequalities through the role of S&T, but also to understand processes that contribute to mitigate inequalities through S&T. The enhanced role of S&T in the global knowledge economy gives such understanding urgency. ResIST will:Analyze how global policy contexts for key S&T processes affect the distribution and redistribution of knowledge resources, and the scope for alternative framings (WP 1);Identify the features of effective policies and programmes to build S&T human capital and institutional capacity in disadvantaged populations and places (WP 2);Critically assess new initiatives to construct S&T priorities reflecting the needs of the disadvantaged, and review current constraints and future opportunities for their full realization (WP 3A);Map structures of accountability in the distribution of technological risks, and propose effective accountability channels to protect the poor from such risks (WP 3B);Model the impact of new research-based technologies on the poor through dynamics such as employment, lowering costs, and impact on public services (WP 4).In a horizontal activity, involve policymaker and practitioner stakeholders in three representative world regions in Europe, in Southern Africa and in the Caribbean and Latin America in the process of developing and implementing options identified in the Project. In particular use the insights developed in 1-5 to test with stakeholders the opportunity to deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Late-stage photocatalytic functionalization of alkenes and 1,3-dienes' to be submitted under Horizon Europe.

assistant: **Abstract**

The late-stage functionalization (LSF) of bioactive compounds is currently a hot topic in the chemistry community, as it allows for the rapid and divergent construction of molecule complexity and avoids the need for time-consuming de novo synthesis. This is especially relevant in the fields of drug discovery and medicinal chemistry where the fast identification of structure-activity relationships is crucial. Especially intriguing in this context are alkenes and 1,3-dienes, as they are frequently occurring motifs in natural products and drug molecules including important antibiotics and antivirals. However, methods for the introduction of a broad variety of functional groups via the LSF of these moieties remain underdeveloped. LateFun aims to create new chemical space by developing a first-in-class methodology for the incorporation of a highly versatile functional handle via the LSF of alkenes and 1,3-dienes, whose well-established subsequent transformations will allow for the rapid assembly of diverse structures. Applying this innovative protocol to the LSF of complex natural products and drug molecules will be of great importance and impact, going beyond the current state of art. The real-life applications of this cutting-edge research proposal will be explored during a secondment phase in Novartis (Basel), providing for valuable industry insights and interdisciplinary aspects. The host’s expertise in late-stage functionalization of bioactive molecules using catalytically generated carbyne equivalents perfectly complements the applicant’s strong background in photocatalysis and therefore guarantees two-way-transfer of knowledge between the host group and the ER (Experienced Researcher). The successful implementation of this action in the highly international and interd
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Persianate Jews: Mobility, Community, Memory' to be submitted under Horizon Europe.

assistant: **Abstract**

Who are Persian Jews and what can we learn from their history? Looking back on a history of almost 3000 years, the majority of Jews left the Persianate world from the mid-20th century onwards. As Jews who lived in Muslim cultures, their trajectories do not fit into mutually exclusive concepts of “Jews” and “Muslims”. However, we hardly know how interactions between Muslims and Jews worked on a daily basis because the contemporary narratives about Jewish-Muslim relations tend to be highly polarized, and access to sources in Persianate societies is hampered. Based on different forms of interconnectedness, this research provides the first comprehensive study about Persianate Jews from the 19th century until today. It analyses Jewish contacts within and outside of their communities in everyday life, to shed light on the various forms of connecting with and separation from the surrounding Muslim societies. It highlights religious identity as applied in context, rather than as fixed notion. This can only be achieved by an innovative method of combining a variety of sources that have not been brought into dialogue until now, including the different languages Persianate Jews used. Focusing on non-elites and everyday life also includes a completely new pool of data that until now was considered too mundane for analysis. Yet, exactly these documents from ordinary people and daily encounters provide significant new insights into Jewish life in the region, the role of transregional networks and their connection to global markets. In this way, the project aims to overcome the geographic, disciplinary and linguistic separation that has shaped modern Persianate Jewish history to date. Expanding this method systematically to a number of different archives will generate significant new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Custom architecturally defined 3D stem cell derived functional human neural networks for transformative progress in neuroscience and medicine' to be submitted under Horizon 2020.

assistant: **Abstract**

The development of methods to isolate and generate human stem cells along with technology to selectively differentiate them into specific cell and tissue types has excited many with the promise of the ability to study human cell function and utilise them for regeneration in disease and trauma. However, to date, attempts to develop regenerative brain and central nervous system therapies have been disappointing, with the introduced stem cell derived neurons not integrating nor signalling physiologically with endogenous cells.  A major confounding issue has been that derived neurons are grown in two dimensions, which does not mimic the in vivo three dimensional interactions nor the myriad developmental cues they would receive in vivo. We will develop functional three dimensional human stem cell derived neural networks of defined and reproducible architecture, based on that of a brain cortical module that will display in vivo connectivity and activity. The networks will be seeded on nano-scale designed femtosecond laser printed scaffolds using novel polymerisation methods that will allow electrical stimulation, simultaneous recording and light sheet imaging during development and at maturation to interrogate network function. Cells will be seeded at and will develop at specific, defined points on the network scaffold, enabling the growth of realistic and reproducible functional neuronal networks. The proposal seeks to provide fabricated reproducible scaffolds that can be produced on a large scale. These concepts are far outside what is currently pursued in the field. The development of such a technological platform will be foundational for a new era of biological and medical research based on human neural networks. Cellular neuroscience research and pharmaceutical drug disc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CHEOPS Very High-Power Building Blocks' (CHEOPS-VHP-BB).

assistant: **Innovation**

For the future of space exploration and space logistics, and to reduce costs for orbit transportation of future payloads, very high-power Hall Effect thrusters of 20 kW or above are at the forefront of several initiatives today. Be it as single or clustered units, the combined thrust of these electric propulsion systems (EPS) paves the way to allowing larger spacecraft and more ambitious missions to be envisaged. However, given that these missions would require significant burn time of the EPS, several important issues must be addressed that go beyond the simple ability of manufacturing larger EPS components. Specifically, qualifying such electric thrusters for lifetime is currently a showstopper.In the race to the Moon and Mars, as well as other lucrative commercial missions within earth’s orbit beyond 2030, the European Space industry must catch up with the US. Studies within Europe have already been initiated for the incremental development of 20-kW class Hall thrusters such as the FP7 HiPER project which produced the PPS®20k ML thruster up to TRL4, FP7 CHEOPS project which permitted SITAEL to develop their 20kW HET, ESA projects allowing UNIPI to develop their nested multi-channel TANDEM thruster or the ongoing H2020 ASPIRE project led by SITAEL. Nevertheless, given the challenges and the opportunities that VHP present, research such as proposed in CHEOPS-VHP-BB must be anticipated now ahead of its effective deployment in 2030-40. Project activities will complement ongoing thruster-focused development activities with research and development on key building blocks essential for the future use of VHP Hall thruster systems: overall system architecture against various mission use cases, robust and cost-effective approach to qualification using Probabilistic Failure Ana
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'HERA Joint Research Programme Uses of the Past'.

assistant: **Objectives**

AbstractThe HERA Joint Research Programme Uses of the Past (HERA JRP UP) consortium will establish a 3rd joint transnational programme for multi-disciplinary research into a topic at the heart of the reflective society: ”Uses of the Past”. The innovative projects funded will fundamentally link past(s), present and future(s) creating valuable new knowledge that gives insights into the forces shaping the social, cultural and political transformation in Europe today. The HERA JRP UP will also pursue additional activities aiming at international capacity-building in humanities research, promoting embedding of humanities researchers in Horizon 2020, and will explore and prepare new joint actions.Twenty-four organisations from 23 countries have pooled a substantial amount of their humanities research funding (21 M EUR) for this HERA JRP, thus increasing the efficiency and impact of public funding. The HERA JRP UP involves the launch of a joint Call for Proposals and a commonly-agreed two-stage evaluation process involving an independent, international Review Panel. The consortium expects to fund 21 transnational humanities centred projects of ~1.2 M EUR each. EC support is awarded to the level of 33% of the joint call budget. The HERA JRP UP consortium will actively support knowledge exchange activities and stimulate wider dissemination about the valuable contributions of new humanities research. With this large transnational JRP and its associated activities the HERA JRP UP will mobilise the intellectual energies and collaborative potential of a wide range of humanities disciplines, and further develop the knowledge base of the European Research Area by sharing and debating interpretations of the human past and its relation to the present and future. While this proposal is f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A Molecular Framework for Plant Cell Totipotency' (POTENTIATE).

assistant: **Concept**

This proposal aims to unravel to signalling pathways that underlie induced plant cell totipotency, by combining cell and molecular techniques to chart the changes that take place as differentiated pollen cells are induced to switch developmental pathways and form embryos in culture.Immature male gametophytes can be induced to change their developmental fate from pollen to haploid embryo development when exposed to stress treatments in vitro. This process (microspore embryogenesis) is widely exploited in plant breeding to generate homozygous (doubled-haploid) lines in a single generation, and also provides a unique system to understand plant totipotency and early cell fate decisions. In this proposal, I aim to understand the molecular basis for this switch in developmental pathways in Brassica napus. I will combine cell tracking, cell sorting of fluorescently tagged cells and high-throughput transcriptome sequencing to chart the changes that take place as immature pollen are converted into haploid embryos, and will also determine the function of a selection of genes in the model plant, arabidopsis. The project will advance my career by broadening my existing cell biology expertise, by providing training in a new field, molecular biology, and by allowing me to work with the plant model, arabidopsis. In addition, my network will be expanded to include a large group of internationally active scientists and seed companies. This novel combination of classical and state-of the-art skills, combined with the experience of working with top international groups and a plant breeding company, will place me in a solid position for a career in academia or industry.