RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Design of Enhanced Reliable GNSS/UWB Personal Navigation Devices (EIGER)' in the context of a Seventh Framework call.

assistant: **Objectives**

The project focuses on the design of a propagation environment-independent hybrid GNSS/UWB-based standalone Personal Navigation Device (PND) that is able to meet the today’s most stringent Location Based Services (LBS) requirements in both outdoor and indoor situations. The envisaged PND exploits tightly coupled GNSS and UWB positioning techniques to efficiently act in both outdoor and indoor situations. This virtually eliminates the problem of the handover when the PND moves from one environment to another, making itself intrinsically adaptive to the propagation environments. The EIGER project proposes a global approach to resolve this issue by focusing on the exploitation of the efficient joint use of GNSS signals and UWB positioning in order to allow permanent and reliable outdoor/indoor localization.The PND software and hardware design will be jointly optimized, allowing manufacturing of small and low-power PNDs. The EIGER consortium will resolve a set of complex and multidisciplinary issues to successfully design the envisaged PND.The main application of this device is dedicated, but not limited, to situations where transitioning from indoor to outdoor, are frequent and unavoidable such as: shopping malls, warehouses, large scale metropolitan events (including museums, institutional buildings and points of interest), ports and airports.The related market segments will be immediately explored by the consortium SMEs through the establishment of efficient and feasible business models and exploitation plans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Oxygen-sensitive enzymes of the mevalonate-independent isoprenoid biosynthesis pathway as targets for new antimalarial and anti-TB drugs' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

In Plasmodium and Mycobacterium, isoprenoids are synthesised by the mevalonate-independent 1-deoxy- D-xylulose 5-phosphate (DOXP) pathway which is absent in humans. The last two steps of the DOXP pathway are mediated by enzymes which contain oxygen-sensiti ve iron-sulphur clusters and catalyse unique radical-type reactions. Using an advanced High Resolution Screening technology the project aims at the identification of lead inhibitors to be developed as novel drugs against malaria and tuberculosis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Drug use in pregnancy' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The objective is to study possible side effects related to drug use during pregnancy using classical epidemiological designs. The study will focus upon asthma drugs, antibiotics benzodiazepines, non-steroidal anti-inflammatory drugs, neuroleptic and antidepressant drugs and ovulation-induced treatment of infertility. A number of different data sources are used.Proposal summary pregnant women are usually excluded from medical trials and results from animal studies need not apply to human populations. Treating pregnant women with some drugs is thus often a problem and most clinicians have a rather restricted approach to use of drugs during pregnancy. On the other hand, there are situations where treatment cannot and should not always be avoided.Existing adverse drug reaction monitoring systems based on spontaneous reporting do not provide data which allows risk assessment and large scale follow-up studies are very difficult if not impossible to conduct in most European countries. In this respect the Scandinavian countries and Hollanc offer a unique opportunity to set up large scale studies which use the existing population registers and health monitoring systems to provide data on the short-term and long-term safety of over-the-counter and prescribed drugs in pregnancy. Still, very large-scale studies in this field have not been conducted within a proper epidemiological framework in the last 40 years, and recent small-scale studies indicate side effects related to commonly used drugs in pregnancy presently in Europe. The present application is collaboration between a number of European research teams with access to a number of existing data sets and studies in progress. The purpose of this collaboration is to exploit the joint knowledge of the research teams in order to s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Selective expression of fluorescent and luminescent reporter transgenes in an interneuron subtype to dissect the functional diversity of brain networks' (1994-1998).

assistant: **Innovation**

The understanding of the functional consequences of neuronal diversity requires a precise identification of neuronal types to study the modalities of their synaptic communications and of their specific contributions to the function of the brain. To investigate these issues, we propose to express specifically fluorescent and luminescent reporter transgenes in a restricted neuronal subtype in order to identify and monitor these cells selectively among the network. Interneurons, which regulate locally the function of neuronal networks by synchronising the activities of individual neurons, are characterised by an extreme diversity at the biochemical, functional and morphological levels. The current investigations of neocortical interneurons by Rossier using single cell RT-PCR after patch-clamp in acute slices, show that the expression of the neuropeptide somatostatin (SS) defines a population of interneurons which have common molecular and functional properties but cannot be recognized by their morphology in-vivo. The fact that this population constitutes a major inhibitory level acting on neocortical efferent pyramidal neurons (layer V) is also of great interest in this project. The aim of the proposal is to divert the strong SS promoter to drive the specific expression of transgene reporters in these interneurons. The reporters are Green Fluorescent Protein (GFP, fluorescent), and Aequorin (luminescent upon increase of intracellular calcium)/ which both have been used extensively by Pozzan. A transgenic rodent line expressing GFP has recently been reported. The SS containing interneurons expressing GFP will be identified in acute slices by their fluorescence. This will greatly facilitate their study in the context of the local network by electrophysiology and molecular te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mathematical modelling of nanoscale heat flow and phase change' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The nanoparticle (NP) lies at the very heart of nanotechnology. The wide range of current and potential uses of NPs, which include medicine, manufacturing, environment, and energy, has stimulated an international research effort focusing on NP synthesis and design. Despite extensive research into NPs, many breakthroughs and advances are the result of trialand error, since the mathematical framework which could provide a theoretical understanding often does not exist.This is partly because classical theories of heat transfer and phase change, which are relevant to the design anduse of NPs, breakdown on the nanoscale.The focus of the proposed research is, therefore, to develop and analyse novel mathematical models describingnanoscale heat transfer and phase change.  Exact, approximate, and numerical solutions will be obtained in orderto gain practical insights into NP evolution.  To ensure the models and results are realistic and of use tonanoscience researchers, the work will be carried out in collaboration with members of the Inorganic NanoparticlesGroup of the Catalan Institute for Nanoscience and Nanotechnology, and the Statistical Physics Group at the AutonomousUniversity of Barcelona.  The project, which is truly multi-disciplinary, will bridge the gap between mathematicsand nanotechnology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Continuous sub-mK refrigeration by demagnetization of atomic nuclei', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The proposed ERC PoC project is to construct the first continuous nuclear demagnetization refrigerator (CNDR). Reaching temperatures near 10 mK has become relatively easy in the last decade. This cryogenic advance has driven an explosion in industrial efforts to build quantum computers based on superconducting qubits as well as rapid progress in fundamental physics experiments around 10 mK. However, cooling condensed matter below 1 mK remains challenging. Furthermore, there is no continuous cooling technology at this temperature. The CNDR will solve this problem by maintaining the sample temperature below 1 mK indefinitely while providing a large experimental space and eliminating the need for a liquid helium supply. We expect the CNDR to allow rapid investigation of qubits whose coherence is enhanced at temperatures << 10 mK and to propel work in fields ranging from nanomechanics to topological superconductivity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The first wall-integrated, ecologic sound absorbing panel', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

SOUNDCOMB+ is the first wall-integrated sound absorbing panel, designed to reduce interior noise to the lowest levels possible in all frequency ranges. By integration into walls, an entirely new palette of potential applications opens up in addition to wall panels, such as wall insulation and office cubicles, while providing full designer flexibility. The panels can be integrated into any room or building and comprise 100% ecologically sustainable materials and offer users of these buildings comfortable acoustics, higher hygiene standards and custom-made designs.  SOUNDCOMB+ was developed by Christian Fuchs, an Austrian designer/specialist in materials processing. Based on a client’s request he and his co-workers developed a box-shaped acoustic panel that has full flexibility in surface design, i.e. any colour or 2D/3D-print can be achieved, creating all kinds of novel effects while absorbing sound to over 95%. SOUNDCOMB+ offers our clients (mainly architects and interior designers) the first acoustic panel that functions as integrated building element rather than as individual mono-functional element.  We have developed first prototypes of SOUNDCOMB+, prepared fixation, assessed the sound absorbance performance with all components assembled, and had the absorbing panel itself certified as a building material, bringing it to its current TRL6 stage. This EU project intends to further optimise these features and prepare for the production of the elements and commercialisation throughout the EU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel method for the extraction of lycopene fom tomatoes, tomato-related products and tomato-waste' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Limonene is a carotene with proven health benefits, such as a decreased risk of cardiovascular diseases and it is therefore expected that limonene will soon be in great demand as a new food additive (nutraceutical) to improve the quality of life. The main source of limonene is tomatoes or rather the waste from the tomato processing industry, which is abundantly available. However the currently available extraction technology is based on the use of hazardous, highly flammable solvents requiring very restrictive safety measures so that it has become almost impossible to set up any new, large scale extraction facility in the EU. Consequently the tomato processing industry is very keen to be able to exploit the anticipated large demand for limonene, by using another safer and more environmentally friendly processing technology. It is believed that the proposed new technology will be not only be absolutely safe, non hazardous and environmentally friendly, but also much more effective.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Product End-of-Use Management Networks' (EOUNETWORKS) targeting Seventh Framework.

assistant: **Abstract**

Increasing rates of consumption and disposal result in products that arrive to their end-of-use stage while retaining economic value and suitable for reuse and recycling. Although theoretically promising, relatively few circular supply loops are self-sustaining in practice. This evidence raises the question of why voluntary economically viable product end-of-use management network of agents that are involved in such activities (i.e., recycler, remanufacturer, consumer, collector, etc.) are not operating on a large scale yet. In response, I argue that such networks are complex systems and not well understood as yet. Therefore, in this research I propose to advance the knowledge and understanding of how such networks of product end-of-use (EoU) agents emerge and evolve in response to market conditions, regulation, and changes in each other’s corporate strategy. I propose to combine industrial ecology and operations management concepts using agent-based models with data from the U.S. and Israel as a tool to examine environmental and economic performance patterns of each agent and the overall network (i.e., the market). The socio-economic rationale for this research is the need for better understanding how to design product EoU collection and processing networks in order to increase dramatically the economic and environmental efficiency of such systems. This research is valuable to policy makers formulating and revising product EoU regulations and to the different EoU agents looking to gain competitive advantage while complying with regulations. It combines methods from the industrial ecology and management disciplines and such interdisciplinary approach to a very timely manner problem aligns well with the work program goals. The researcher had partnered with multiple resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Development of an electromagnetic valve actuation system for high efficiency engines'.

assistant: **Objectives**

Engine Electromagnetic Valve Actuation is a new technology based on electromagnetic actuators and control electronics instead of pure mechanical valve driving. The general objective of the ELVAS project is to develop an improved Electromagnetic Valve Actuation System with lightweight valves and materials to reduce valve actuation power losses and be in a position to maximise fuel economy. The consortium involves 2 industries (a supplier of valve actuation systems and a supplier of engine intake and exhaust valves) , 2 research institutes The expected results are: new electromagnetic actuation systems with light weight valves, new testing guidelines for such components, and selection of manufacturing routes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'An integrated approach to restore tolerance in autoimmune disease'.

assistant: **Concept**

The TOLERATE training network aims at training DC’s to acquire the skills to develop different innovative strategies to treat autoimmune diseases, to identify the most promising strategies or a combination of strategies, to setup clinical trials and to develop a roadmap to bring a novel therapeutic agent to the market. This all will be done in a highly interdisciplinary and intersectoral environment. Interdisciplinarity allows to introduce innovative tolerogenic therapies developed for cancer, Chimer Antigen Receptor (CAR)-T cell therapies, into the world of autoimmune disease and to apply nanotechnology and protein-engineered tolerogenic vaccines to re-establish immune tolerance in autoimmune disease. Both the presence of academia and industry provides a platform for in-depth preclinical studies and a realistic possibility for future commercialization of the novel therapies. Clinicians in the consortium with expertise in setting-up and running clinical trials for novel drugs assure that developed novel therapies in TOLERATE will find their way to the clinic in the future. Developing novel therapies for autoimmune diseases goes close together with a thorough knowledge on the long-term consequences of living with an autoimmune disease. Since many autoimmune diseases are rare diseases, setting up international uniform databases and biobanks is crucial to understand the long-term pathophysiology of the disease and to guarantee optimal use of (novel) therapies. TOLERATE will train 8 DCs who will hence has the expertise and skills to work in and setup interdisciplinary and intersectoral projects. The ground-breaking training programme will provide the DC’s with a unique clinical training. Additional training in ethical, regulatory and legal aspects together with a training i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Post-transcriptional Control of the Aire-Driven expression of self-antigens in the Thymus' under Seventh Framework.

assistant: **Concept**

Immune tolerance is key to the maintenance of the integrity of organisms against foreign invaders with respect to self-constituents. Deregulation of this mechanism promotes the occurrence of life-threatening autoimmune diseases that affect 5-10% of the general population. Previously, the transcriptional activator (Aire) was shown to play a key role in immune tolerance. Indeed, Aire induces medullary epithelial cells in the thymus (MECs) to synthesize and present a large repertoire of peripheral self-antigens (a “self-shadow”), leading to the clonal deletion of self-reactive maturing T cells and thereby protecting against autoimmune manifestations. In addition to activating transcription, preliminary results indicate that Aire induces 3’UTR shortening of its sensitive transcripts in MECs, and that these cells show an accumulation of miRNAs. The goal of our project is to describe a post-transcriptional control of the Aire-driven expression in the thymus that leads to higher levels of Aire-dependent self-antigens, and to identify key molecular players involved in this mechanism. We first propose to confirm that Aire-induced transcripts have shorter 3’UTR ends by mRNA high-throughput sequencing in primary MECs, and that these transcripts escape a miRNA-mediated post-transcriptional repression in a MEC cell line. We will also seek factors involved in Aire-triggered 3’UTR shortening by performing a lentivirus-based RNAi screen of a set of RNA-binding proteins in an in vitro model that we will set up. Finally we will validate some of the best candidates in vivo by generating knock-down mice using a high-speed lentigenic approach based on oocytes infection with lentiviruses delivering targeting short-hairpin RNAs. Altogether the expected results should uncover an important laye