RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Developing Experience-Centric Accessible Immersive Virtual Reality Technology' under Horizon Europe.

assistant: **Concept**

AccessVR will fill the gap in the scientific knowledge on how people with physical disability – particularly people with limited upper- and lower body mobility – access and experience Virtual Reality (VR) technology. Many of the several million physically disabled people in the EU cannot tap into the huge potential of the technology for leisure, education, and work: VR systems are commonly designed for non-disabled human bodies, but as a result of the complexity of VR technology, fundamental accessibility barriers for physically disabled users remain unaddressed.AccessVR addresses this issue through development of an experience-centric framework for accessible VR technology. The framework will build on technology case studies and a modular VR application that address physical and digital access barriers to VR, and will be constructed against disability studies as theoretical backdrop. The first phase of the research will examine preferences and needs of disabled people regarding user interfaces and representation of disability in VR through co-creation of individually tailored VR prototypes. In a second phase, the project will synthesize outcomes into a middleware layer, and develop an adaptive VR platform featuring entertainment and workplace scenarios. In the third phase, the VR platform will be leveraged to evaluate the experience of physically disabled people in VR to refine the framework based on empirical data.The goal of AccessVR is to further our understanding of how to create engaging VR experiences for people with physical disability that combine the removal of physical, digital, and experiential access barriers. Results are expected to have significant impact on the design of body-centric technology and the inclusion of physically disabled people. Ultimately,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Analysis of the nod factor signal transduction cascade. Effects of inositolphospholipids on change of the cytoskeleton'.

assistant: **Innovation**

The Rhizobium-legume symbiosis is set in motion by a signal exchange between plant and bacterium. The bacterial production of the so-call Nod factors play an essential role by triggering several plant responses like root hairs deformation, the formation of nodule primordia and the induction of several transcriptional-regulated plant genes. However, the signal transduction pathway leading to plant response is unknown. As it was mentioned, Nod factors induces root hairs deformation and this event is visible within 1 h of the induction. Although calcium ion and phosphoinositides have been suggested to play a rolet further studies are necessary to establish the transducer and second messenger involved in the transduction pathway. Firstly, by using a confocal microscope linked to a microinje(tion equipment we will be able to follow the Nod factors responses by measuring the effect of microinjected drugs in root hairs deformation. We will be focused on the inositolphospholipid signaling following preliminary studies on the metabolism of the precursor phospholipids. Secondly, by using a cell biology approach, we will study the involvement of phosphinositides in the actin cytoskeleton changing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantum Optical Networks based on Exciton-polaritons' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

One of the main needs in Quantum Optics and Quantum Information is the ability to generate, manipulate and characterize arbitrary quantum states both in discrete and continuous variable domains. Q-ONE aims at exploring a novel approach for sensing and generating quantum states of light based on quantum neural networks (QNN) in integrated photonic devices. This proposal has the ambition to solve one of the most interesting problems of quantum mechanics: the recognition of quantum states of photons, like Fock states or entangled pairs, without the need of correlation measurements. Moreover, our platform has the ability to be reversible: by injecting a quantum state into the QNN, the output gives access to the full characterization of the input quantum state; conversely, with a classical state of light as input (a coherent state, emitted by a laser), an arbitrary quantum state can be generated on demand at the output of the QNN. This is all realised in a single device.The project idea places itself at the frontier between quantum physics and applied artificial intelligence, building on top of state-of-the-art semiconductor material growth and processing. The consortium targets the realization of a novel device based on strongly interacting photons (exciton-polaritons) that, using principles of neuromorphic computing, is able to recognize, characterize, and generate a variety of quantum states. Importantly, we propose to exploit the properties of a quantum neural network which is able to identify and generate quantum states without the need to reach extreme single-particle interaction strengths: this innovative idea relies on the physical realization – rather than the simulations – of a massively parallel computing task.If successful, the Q-ONE approach will enable the real
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Novel strategies for the cell therapy of muscular dystrophies' (2007-2013).

assistant: **Concept**

This project aims to develop an effective cell therapy for Duchenne Muscular Dystrophy (DMD). To reach this goal we plan to transfer a human artificial  chromosome containing the whole dystrophin locus into dystrophic mesoangioblasts. As the transfer is inefficient and requires selection, it is impossible to use primary cells that would undergo senescence during selection. Therefore we need to reversibly immortalize DMD patient mesoangioblasts by the combined use of lentiviral vectors expressing either floxed human telomerase (h-Tert) or floxed Bmi1 (and also the Herpes Simplex Thymidine Kinase, HSTK). Immortal clones, selected for proper expression of h-Tert and Bmi1 and maintenance of a mesoangioblast phenotype, will be transfected with a human artificial chromosome expressing human dystrophin. Expressing clones will be selected and characterized. Before transplantation, selected clones will be infected with an adenoviral vector expressing the Cre recombinase and then treated with Gancyclovir. Transduced and selected cells will be transplanted into mdx/SCID (dystrophic and immune deficient) mice and the extent of dystrophin reconstitution and consequent functional benefit will be evaluated. In addition, the possible immune reaction to the transgenes or novel antigens generated by the experimental strategy will be monitored by an in vitro assay utilizing donor s dendritic cells and T lymphocytes.  Finally this strategy will be repeated in Golden Retriever dystrophic dogs, the closest animal model to DMD. Dog mesoangioblasts will be reversibly immortalized, transduced with the dystrophin HAC and, after viral excision and GC selection, transplanted in the same dogs from which they had been directly isolated.  Dystrophin expression, functional amelioration and possible to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Preclinical Human In Vitro Drug Immune Response Analysis Platform'.

assistant: **Innovation**

Drug-induced tissue damage and the associated risk for developing auto-immune secondary disease is fully ignored in preclinical toxicity testing. As a consequence, there are currently 300 drugs on the market that cause drug-induced auto-immune-mediated interstitial lung disease. In their regulatory documents, EMA and FDA strongly advocate for inclusion of tests to address this type of adverse effects in preclinical research. Immundz (www.immundnz.com) addresses this market opportunity by developing a unique and innovative platform, PHIVIDIAS, for comprehensive preclinical analysis of drug-induced tissue damage and the immune response against molecules released from the damaged cells, together with a computational model for risk assessment for developing auto-immune secondary disease. The testing platform will be animal free. Key persons from the client networks and a variety of other small and large companies have already been approached to assess their interest in the PHIVIDIAS platform. Their feedback identified a significant need for the PHIVIDIAS test platform and a variety of companies expressed their commitment to use the services. With PHIVIDIAS, Immundnz will be first in the market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sustainable production of plant-derived indigo' (SPINDIGO), addressing dissemination and exploitation.

assistant: **Impact**

The project aims to introduce indigo-producing crops into European agriculture, tithe long-term benefit of the rural sector and the environment. The current European market for indigo, supplied entirely by the synthetic product, amounts to8, 000 tonnes p.a. By 2005, the project aim is that at least 5% of the European market is met by natural indigo with a purity of >90%, grown on 20,000 hectares providing the rural sector with an income of at least 32 m euros p.a. The project will provide: seeds and an agronomic blueprint for farmers; identify among three different crops which are best for the different European regions; on-farm technologies for indigo extraction and purification; DIN dyeing standards of the product, and an environmental impact assessment. The multidisciplinary team is vertically integrated, drawing on the leading academic and commercial (SME) players from the whole production chain.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PV STAND-ALONE AND HYBRID SYSTEMS IN NATURAL PARKS OF SPAIN AND FRANCE' in the context of a Fourth Framework call.

assistant: **Objectives**

The technology objectives : to provide standard quality electrical supply and hot water with non-polluting solution; improved cost effectiveness of components by integration of all power conditioning, monitoring and regulation into one single modular unit; reduction of downtime and maintenance costs through standardized layout.Strategic aims : to guarantee maintenance and repairs of PV rural electrification equipment through a service contract backed by telemanagement; To complement PV with solar DWH within the same service contract of supply; to develop a new management model appropriate for this technology involving natural park authorities; local governments and users association; the adoption of these technologies in Natural Parks not only meets nature protection objectives; the creation of jobs by imploying local SME into the installation and maintenance; to set the basis for a communications network among users to share information on high efficiency appliances.This project achieves the functional integration of the following systems :- stand-alone PV electrification installation to supply the necessary amount of electric power, ( on some sites with back up generators)- standard quality of supply (230 V AC, sinusoidal wave), high reliability (cascading inverter power steps), improved efficiency (MPPT)- Solar Water Heating : the system provides DHW or substitutes the electrical resistances of washing machines and dish washers. The system consist of solar collectors and hot water tank with heat exchanger.- centralized energy management and measurement : there is only one integrated control system that manages energy sources as well as load priorities. Loads can be managed according to energy availability (i.e. washing machine is activated if there is hot water and P
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Malopolska Researchers' Night 2010' (MAGIC2NIGHT) targeting Seventh Framework.

assistant: **Abstract**

If you wish to accompany researchers on an exploration of the mysteries of the world, come to Malopolska on 24 September 2010! On this unique night Malopolska will once again go science mad. Adventures with researchers will take place in three cities of the region: Krakow, Tarnow and Nowy Sacz. Researchers’ Night will provide a chance to meet and interact with researchers not only in their natural habitat but also in unexpected situations and venues. On this once-in-a-year occasion researchers will take on different personas: those of excellent actors, brilliant directors, guides through the mysterious nooks and crannies of scientific laboratories, sports competitors and geniuses who know the answers to almost any question. The event will provide an excellent opportunity to challenge the stereotypes and promote the image of researchers as a colourful, attractive and creative community. By gaining an insight into the work of researchers, young people will be encouraged to consider a career in research as an alternative to the much-advertised professions in business, entertainment, politics or the media.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Exploring Asgard archaea to illuminate the prokaryote-to-eukaryote transition' in the context of a Horizon 2020 call.

assistant: **Objectives**

The origin of the eukaryotic cell, with its complex structural features, marks one of the prime hallmarks in the evolution of life on Earth. Still, the events that led to the emergence of cellular complexity in eukaryotic cells are a matter of hot debate. Current data supports scenarios in which an archaeal host cell and an alphaproteobacterial (mitochondrial) endosymbiont merged, triggering the emergence of the first eukaryotic cell. The host cell was recently shown to share a common ancestry with the Asgard archaea, an archaeal superphylum uniquely displaying a number of eukaryotic features. However, important details about the nature of the archaeal host and the presumed syntrophic interaction between this host and the alleged mitochondrial endosymbiont remain elusive, limiting our current understanding about the early stages of eukaryogenesis. In the current proposal, I aim to gain new insights in the emergence of eukaryotic cellular complexity by focusing on the newly discovered Asgard archaea. First, I will acquire and screen numerous environmental samples and employ state-of-the-art genome-resolved metagenomics approaches to lay out the diversity of the Asgard superphylum at the genomic level. By performing in-depth phylogenomic analyses of the newly generated genomic data, I will pinpoint the position of eukaryotes in the Tree of Life, and reconstruct the evolutionary history of eukaryotic genome content using advanced ancestral genome reconstruction algorithms. Next, I will develop in situ culturing and innovative cell extraction techniques that allow me to determine metabolic and syntrophic properties of Asgard archaeal cells, and to study their cells in ultra-high resolution. Altogether, the proposed research will provide novel insights into the genomic and c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'An innovative thermochemical cycle based on solid sulphur for integrated long-term storage of solar thermal energy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

SULPHURREAL aims at demonstrating and validating a breakthrough approach for next generation, carbon-free, direct conversion of solar energy into chemicals storable for a virtually unlimited time, based on elemental sulphur produced and consumed on-demand via a solar-aided thermochemical cycle. The project is targeted on the one hand to develop disruptive catalytic technologies for the two catalytic steps of this solid sulphur thermochemical cycle, namely the high- (800-850 C) and medium- (600-650 C) temperature catalytic SO3 splitting to SO2 and oxygen and the subsequent disproportionation of SO2 to solid sulphur and sulphuric acid. The research line involves identifying, developing and testing novel catalysts and reactor designs under operating conditions so that these two, less developed steps of the cycle cf. sulphur combustion, can be integrated and performed in sequence with maximum compatibility in a first-of-its kind integrated approach. Innovations to be introduced concern not only novel catalyst compositions but also novel reactor designs and methods of applying and distributing the catalysts within the reactors, to achieve maximum utilisation of the active catalytic materials and optimal combination of improved performance, conversion efficiency and process cost reduction. On the other hand, SULPHURREAL will further develop and upscale a first-of-its-kind sulphur burner operating at power density > 5 MW/ m³ at ambient pressure and having demonstrated potential for prolonged operation at power densities of > 75 MW/cbm for typical operating pressure of 15 bar by simulations. The proposed combination integrates renewable energy sources (solar energy) with valorisation of non-CRM substances currently produced as industrial by-products from oil and gas (solid sulp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Testing the Relative importance of factors in speciation: the Martinique Anoles'.

assistant: **Concept**

Biodiversity, in the term of genetic diversity, can be generated within a species, although an increase in biodiversity is usually thought of as involving an increase in the number of species by speciation. Speciation is thus of key interest to both ecologists and evolutionists.The traditional view of speciation is that it generally involves divergence of populations over time while they are geographically apart (vicariance). This view has recently been increasingly challenged and more emphasis has been placed on ecological speciation.The central issue of this project is to test the relative importance of the various factors potentially influencing speciation, i.e., vicariance, natural selection and sexual selection. The Martinique anole is an outstanding model for such a study. Indeed, in this model all the factors (history, habitat, sexual selection, gene flow) are tractable or known.Moreover, it offers several natural replicates that can improve the generalisation of results. Reduction of gene flow (as measured using micro-satellites) will be estimated on several transects between deep phylogenetic lineages (test of vicariance), between different colour morphs (test of sexual selection) and between different habitats (test of natural selection).This project will allow the applicant to develop new skills especially in data analysis and is highly complementary with his previous research experience. This project will allow knowledge transfer from host to the fellow through research training, and from fellow to host, which is situated in a less favoured region. The training will provide the fellow with a unique set of skills that will allow him to become an independent researcher in the areas of interest.The combination of skills of Host and fellow covering the who le ra