RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Atomic surface structure of ternary iii v compounds grown by movpe' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content In this project is planned to cap MOVPE grown samples with the appropriate group V elements with UV radiation from an excimer laser. The surface before capping and the capping procedure will be monitored by RAS. The samples will be tranferred then to an UHV chamber where the deccaping process is initiated under the control of LEED, AES, RAS, Raman scattering and other UHV techniques like Thermal Desorption Spectroscopy. the final surface will be controlled by Auger in order to check its contamination. The innovative aspect of this project lies in the fact that for the first time capped MOVPE grown samples will become available for surface analysis with standard UHV techniques as well as novel optical probes. Training content (objective, benefit and expected impact) Training in specific techniques available only in Berlin Links with industry / industrial relevance(22) A close cooperation existing with AXTRON (Aachen) who are one of the largest producers of MOVPE equipments
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development and application of chiral cation exchangers for lc, ce and cec' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Synthesis of cationic selectors based on chiral synthons derived from natural and non- natural amino acids. Immobilization of the most promising molecular recognition ligand to develop chiral columns. Application of the separation techniques for method development for real world samples and biopharmaceutical studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Centre of microsystems design and technology' (COMBAT).

assistant: **Concept**

The program will support the Centre of Microsystems Design and Technology which will be established at Warsaw university of Technology (WUT) to increase its capabilities at the service of scientific, economic and social needs of Poland in conformity with the interest of European Union. The obtained financial support will be spend on improving links between WUT research groups involved in the Centre and other centres in the European Union and NAS countries. In the future, after lunching FP6, we plan to extend our links to NAB and NIS (Russia, Ukraine) countries. In this project the set of activities like centres networking and twinning, personnel, students exchange and training, centre capacity building and promotion has been prepared. The whole project is divided on 9 work packages. Sixteen deliverables and four milestone meetings are expected.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Brain connectivity metrology for personalised neuroimaging in health and disease' (Neuro-Metrology) targeting Horizon 2020.

assistant: **Abstract**

A key step towards untangling the complexity of the human brain is to understand how functionally specialised subunits are interconnected in the brain’s network to influence each other and produce experiences and behaviour. Magnetic resonance imaging uniquely allows to explore this systems-level view of neural connections and to probe brain organisation.Despite great promise, conventional approaches have experienced difficulties in delivering robust and tangible applications, particularly for the individual, either for neuroscience or clinical practice. The connectome, the comprehensive map of brain connections, is unique in every person; yet there are fundamental limitations in its personalised mapping. Lack of standardised, accurate measures of brain connections and absence of objective references introduce errors and reduce interpretability and reproducibility.I will develop a novel algorithmic platform for brain connectivity mapping, which will establish measurement principles to allow, for the first time, quantitative and objective characterisation of the brain connectome and its individual variability. Through a mixture of highly-interdisciplinary computational and experimental research, I propose to tackle unmet challenges and shift the paradigm from ad-hoc image processing pipelines to a comprehensive framework governed by principles of metrology. I will develop platforms that a) integrate cross-modal information for accurate standardised measurements of brain connections and b) link these measurements to reference standards, reflecting the population, as well as the individual.I will subsequently tackle important representative questions that rely on the ability to capture personalised signatures of the brain architecture: in basic neuroscience, the ability to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Self calibration of active stereo camera platforms' under Fourth Framework.

assistant: **Concept**

Research objectives and content One of the principal aims of computer vision is to develop automated techniques for understanding 3D properties of the environment given video imagery obtained from one or more cameras. Of considerable recent interest has been to what extent information can be inferred about the world when the camera parameters, camera orientations and camera motions are unknown. In this situation, we need to embark upon a preprocess that attempts to recover these factors involved in the picture taking process, prior to computing 3D descriptions of the scene. The process of automated determination of some of the intrinsic and extrinsic camera parameters is termed self-calibration; it forms the basis of the proposed project. In this project, the issue of self-calibration in the special context of a stereo head, perhaps the most commonly adopted binocular camera configuration in robotics, will be revisited. In previous work, closed form solutions were obtained for the calibration parameters and for the ego-motion parameters of the stereo platform, when it undergoes ground plane motion. Key factors of the methodology used for this project will be the consideration of explicit, analytical forms of the fundamental matrix, and the use of the stereo-head state feedback information, provided by the electro-mechanical active stereo platform. Specifically, the objectives of this research project will be the following. To utilise the proposed methodology, based on the study of the analytical form of the fundamental matrix, to extend the self-calibration of the stereo platform to more genera forms of motion. The self-calibration problem when the intrinsic parameters are not fixed between views but free to vary will also be studied. This will permit the cameras to cha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Biocatalytic C-C bond formation by repurposing transaminases' (CCBioCat).

assistant: **Concept**

Carbon-carbon (C-C) bond formation is one of the most challenging synthetic reactions in chemistry. Current approaches require expensive and toxic transition metals with complex ligands that have limited selectivity. Developing biocatalytic sustainable methods for the controlled formation of C-C bonds with stereospecificity in high yields has the potential to advance organic chemistry and provide access to new molecules. Although several enzymes are capable of catalyzing C-C bonds, few biocatalytic approaches have been used in organic synthesis, with aldolases being the most used enzyme group. PLP-dependent transaminases (TA) are the largest and most versatile group, and used at industrial scale, but have never shown C-C bond formation activity. In this project, I will be developing biocatalytic approaches for C-C bond formation by exploring this new functionality of these versatile enzymes.  Thus, I will explore the catalytic versatility of TAs through protein engineering to allow C-C bond formation. Protein immobilization of engineered TAs will support their biocatalytic application in preparative C-C bond formation reactions. This will expand the biocatalytic toolbox available for synthesis, and improve sustainability.This project will be carried in the Biocatalysis section at TU Delft, where I will receive training in protein engineering, while using my experience in immobilization, and co-supervise students. This project will give me the opportunity to further develop the research and supervision skills to become a future group leader.


**Keywords:** Biocatalysis, Transaminases, Carbon-Carbon bond formation, Enzyme Immobilization, Protein Engineering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Structural variants impacting peripheral neurodegeneration'.

assistant: **Concept**

Many Mendelian diseases have benefited from next-generation sequencing (NGS) technologies for gene discovery and the establishment of molecular diagnosis. However, the technical limitations of NGS pose a challenge for identifying mutational mechanisms in genomic regions impenetrable by these technologies. I hypothesize that complex genomic rearrangements called structural variants in these loci can explain a significant proportion of missing heritability in many monogenic diseases. To this end, I propose to investigate the involvement of structural variants in the pathogenesis of Charcot-Marie-Tooth disease (CMT), the most common genetic affliction of the peripheral nervous system. I will utilize long-read Nanopore sequencing in a unique patient cohort to look for potentially disease-causing structural variants. I will then adopt genetic and functional in vitro and in vivo approaches to characterize the identified genomic variants and ascertain the associated functional genes that most likely underlie molecular pathology. The findings of my pioneering study will highlight the contribution of structural variants in peripheral neurodegeneration, discover non-conventional mutational mechanisms long overlooked by state-of-the-art technologies, and deliver in vivo models that might provide clues for therapeutic approaches for peripheral nerve disorders with common etiology.


**Keywords:** long-read sequencing, structural variation, peripheral neuropathy, Charcot-Marie-Tooth disease
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Aerodynamic and thermal load interactions with lightweight advanced materials for high-speed flight' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The objective is to identify and assess lightweight advanced materials which can withstand ultra high temperatures and heat fluxes enabling high-speed flight above Mach 3. At these high speeds, classical materials used for airframes and propulsion units are not longer feasible and need to be replaced by high-temperature, lightweight materials, with active cooling of some parts. First, the overall design for high-speed transports will be revisited to increase the lift/drag ratio and volumetric efficiency through the compression lift" and "waverider" principles, taking into account sonic boom reduction. Second, materials and cooling techniques and their interaction with the aero-thermal loads will be addressed for both the airframe and propulsion components. The former will focus on sharp leading edges, intakes and skin materials coping with different aerothermal loads, the latter on combustion chamber liners. After material characterisation and shape definition at specific aero-thermal loadings, dedicated on-ground experiments are conducted. Both Ceramic Matrix Composites (CMC) and heat resistant metals will be tested to evaluate their thermal and oxidiser resistance. In parallel novel cooling techniques based on transpiration and electro-aerodynamic s principles will be investigated. Combined aero-thermal experiments will test various materials specimens with a realistic shape at extreme aero-thermal conditions for elevated flight Mach numbers. Dedicated combustion experiments on CMC combustion chambers will allow the reduction of combustion liner cooling resulting into NOx-reduction and overall thermal efficiency increase. Finally, particular aero-thermal-material interaction will strongly influence the aerothermal loadings. Conjugate heat transfer , transpiration cool
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Visual object recognition: cognitive,neuropsychological, psychopharmacological, and neuroimaging (PET and FMRI) studies' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

It is the aim of the current project to combine the research skills, interests and resources of research groups in cognitive and clinical neuropsychology with those of research groups in psychopharmacology and neuroimaging for a concerted effort at illuminating some basic problems in visual object recognition. The studies are based on a cognitive model of visual object recognition, and designed to provide answers to unclear issues particularly relating to intermediate stages of visual perception. Specifically, it is planned to study the cerebral organization of processes in form perception, focusing on the integration of form elements into whole perceptions. This will be done by conducting clinical neuropsychological studies of patients with infarcts in the territory of the posterior cerebral artery (in two centers to recruit a sufficient number of patients), and to relate selective deficits of form perception to the localization of lesions on Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). In selected patients the nature of deficits will be studied with cognitive experimental measures in a multiple case study approach. The same processes of form perception will be studied in normal subjects in psychopharmacological studies and in a series of experiments using neuroimaging techniques (Positron Emission Tomography (PET) and functional MRI (fMRI)). In neuroimaging, the plans include comparisons of PET and fMRI in the cognitive activation studies. The cognitive data will also be used in further developments of the imaging data analyses with the specific goals of increasing spatial resolution and modeling non-linear relationships, and making these generally available in a MATLAB toolbox.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dissemination and Technology Transfer of Emerging IST Results to European Union Associated Countries' under Fifth Framework.

assistant: **Concept**

EMERGE is an IST Accompanying Measure Project. Its primary aim is to act as a catalyst for the information flow between the innovative technologies, applications and know-how developed by IST projects covering essential technologies and infrastructures (IST Programme, Key Action IV projects - referred to hereafter as EMERGE-relevant projects) and the Telecommunications & Services Sector in the EU Newly Associated States from Central and Eastern Europe (CEEC-NAS countries). EMERGE will assist in the creation of a level playing field in both CEEC-NAS countries and the EU. It will maximise the ability of both EU and CEEC-NAS countries to compete effectively in the Open Service Market and will contribute to a pervasive Information Society characterised by advanced European technologies and social values. It will actively facilitate partnership networks between EU and CEEC-NAS countries companies with a view to encourage CEEC-NAS countries participation in IST projects.Objectives:The overall objective is to facilitate RTD dissemination and co-operation with actors in the CEEC-NAS countries, thus confirming the international role of European Research. The focus will be on the following themes: Internet centred Networks and Services, Internet Service Creation and Provision, Active and Programmable network and service technologies, Multi-Domain Service Management, Quality of Service Guaranties, services based on optical and mobile networks, Application Service Provision.To this purpose the project will:· develop and implement cost effective mechanisms for on line and off line interactive dissemination of IST results: Virtual Forum, Partnership Networks and Dedicated Sessions at carefully selected conferences· actively promote partnership networks with a view to encourage CEEC-N
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Increasing grain quality through advanced oxidation treatment during storage' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Our company, La Sanfermese, with more than 200 year experience, is specialized in the clearing, drying, storage and commercialization of cereals, in particular maize and wheat. Our main products are white maize, yellow maize, flint maize, durum wheat, peeled durum wheat and calibrated durum wheat coming from non-genetically modified crops (non-GMO) in the Po Valley (Italy). Our main customers are mills and producers of grain-based derivatives. La Sanfermese has an annual storage capacity of 80.000 tons of maize and 40.000 tons of wheat.Since the application in September 2008 of the EC Regulation Nº 396/2005 on maximum residue levels of pesticides in or on food and feed of plant and animal origin, the cleaning of the grain is only performed by mechanical methods, as the most effective synthetic chemical insecticides available for the protection of stored product, such as phosphine, are now banned. On the other hand, EC regulation regarding maximum levels for contaminant in foodstuffs as regards Fusarium toxins (mycotoxin) are every time more stringent, as the new limits set by the EC Regulation Nº 1881/2006 for maize and maize products. This means that, in case the crop has been contaminated during the harvest with insects or fungi (mycotoxins) we have no possibility to eliminate this infection. Furthermore, this situation can get worse during the storage, as once the grain has been infected, the microorganism can grow influence by parameters such as moisture and temperature. In this case, the maize will not be longer suitable for human use and we will have to sell it for zootechnical or industrial purposes (depending on the mycotoxin content), with the corresponding differential price (€45 ton).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Analysis of the interaction of calmodulin and fkb12 with the mh defective ryanodine receptor channel 5' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The RYR1 protein is the main Ca2+ release channel in skeletal muscle SR. Mutations in the gene for this channel are known to cause the inherited syndrome malignant hyperthermia (MH) and make the channel more sensitive to activation by a number of agonists including Ca2+, caffeine, ATP and halothane. In vivo, the RYR1 channel interacts with a number of protein modulators including the irnmunophilin FKBP-12 and calmodulin proteins. In this project I will investigate the effects of RYR1 mutations on interaction of the channel with protein modulators. Specifically, I will use Ca2+ efflux, ligand binding, protein purification, imrnunological detection methods and electrophysiological approaches to perform detailed analysis of calmodulin activation / modulation of, and FKBP 12 interaction with, and modulation of, the normal and mutant RYR1 channels. The results obtained will for the first time provide significant information on the effect of MH mutations on channel modulation by these two associated proteins.