RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Research Facility 2.0: Towards a more energy-efficient and sustainable path' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Research in many cases requires large infrastructures, which often use significant amounts of energy. In particular, research at some of the large-scale facilities, such as particle accelerators, which are either hosted or used at European Level are very energy intensive. Power usage may reach 100 MW or more, with energy consumptions comparable to small towns. To make progress in science, these large-scale infrastructures are essential despite their energy consumption requirements. At the same time, our society is faced with the enormous challenge to transition into a carbon-neutral economy, and to minimize our footprint in terms of energy usage from non-renewable sources, and our output of substances which burden the environment. For this reason, research infrastructures need to develop and use energy efficient technologies. The way we operate our infrastructures needs to be re-evaluated. Intelligent solutions which reduce energy consumption need to be developed. Through intelligent algorithms the energy usage of our infrastructures needs to be adjusted to the available resources, such as renewable energy, and should help in providing an overall stable energy supply to society.The RF2.0 consortium vision is to design and operate accelerators in the way that they can run safe and stable anytime on 100% renewable energy supply, i.e., almost independently from the public power grid.To achieve this vision, comprehThis project’s originality lies in the comprehensive analysis of large research infrastructures’ energy management problem, from component to system level, both at experimental physics and energy engineering level, and in developing and testing in realistic environments of possible corrective actions.The RF2.0 project will involve 6 world renowned research infrast
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Proliferation , differentiation, apoptosis: what's the difference?' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Several aspects of decision-making in a cell are to be addressed in the proposed program, starting from the expression and action of receptors for selected growth factors implicated in neuronal development, via signal-transducing proteins, to specific transcription factors. The growth factors of primary focus are nerve growth factor (NGF) and Insulin-like growth factor -1 (IGF-1). These studies should permit the clarification of the cell cycle specificity of NGF action, opening the way for more precise analysis of this growth factors' effects on proliferation, differentiation and survival of neuronal cell types. In the area of apoptosis, the identification of the IGF-1 and NGF survival pathways and the elucidation of the role of known viral and non-viral proteins in prevention of apoptosis will also be of significant import and impact.Scientific context:  During development, cells are confronted with various extracellular signals that determine their fate. The precise sculpturing of an organism requires careful orchestration of proliferation, differentiation and apoptosis. Furthermore, in the adult animal, extracellular signals are essential for survival and the maintenance of the differentiated state Several aspects of decision-making in a cell are to be addressed in the proposed program, starting from the expression and action of receptors for selected growth factors implicated in neuronal development, via signal-transducing proteins, to specific transcription factors. The end result of the signal transduction being proliferation, differentiation or maintenance of the differentiated state in models for neuronal differentiation, these studies should, in the very least, clarify the role of some key regulatory proteins in the anti-mitogenic, differentiation and survival
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The CD44-RANK-AKT Crosstalk in Breast Cancer and Stemness' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Relapse and metastasis in cancer are driven by cancer stem cells (CSC) which self-renew, give rise to tumor cell heterogeneity and are more resistant to chemotherapy. The RANK signalling pathway is implicated in a number of cancers and notably in breast carcinogenesis and metastasis. Inhibition of this pathway reduces CSCs decreasing both recurrenceRelapse and metastasis in cancer are driven by cancer stem cells (CSC) which self-renew, give rise to tumor cell heterogeneity and are more resistant to chemotherapy. The RANK signalling pathway is implicated in a number of cancers and notably in breast carcinogenesis and metastasis. Inhibition of this pathway reduces CSCs decreasing both recurrence and metastasis. RANKL inhibitors are used in breast cancer clinical trials and studies focused on RANK signalling in carcinogenesis are needed to identify patients who would benefit from treatment. RANK mediates many of its effects on cell survival, migration and chemoresistance via the PI3K/AKT pathway, activation of which confers enhanced proliferation, survival, metastatic potential and resistance to therapy in cancer. AKT is a central node in PI3K signalling and AKT isoforms play important and differential roles in carcinogenesis. RANK is also regulated by CD44, a marker of stemness and a key player in cell migration, proliferation, differentiation, survival, stem cell maintenance and chemoresistance. CD44 alternative splicing plays a pivotal role in cancer development in breast and other tissues. However, the role of CD44 and AKT isoforms in cancer is not clearly defined. In this MSCA project, I will investigate the role of the CD44-RANK-AKT crosstalk in tumorigenesis and identify CD44 and AKT isoforms regulating cancer stemness, metastasis and resistance to therapy. I hypoth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Enantioselective Metal Enolate Alkylation Reactions Under Cooperative Lewis Base and Hydrogen-bond Donor'.

assistant: **Concept**

The reaction between a metal enolate ion and an alkyl halide (or equivalent) electrophile is one of the most useful process for the formation of carbon-carbon bond in organic synthesis. We wish to develop enantioselective metal enolate alkylation reactions under cooperative Lewis base and Hydrogen-bond donor catalysis. The combination of Lewis basic H-bond donor and metal enolate ion to interact cooperatively to both activate and organise the enolate towards the electrophilic component, be it alkyl halide, Michael acceptor or anything else. During this Fellowship we wish to investigate this concept fully with the intention of discovering a new way of generating asymmetry in enolate alkylation reactions through the action of a chiral controller. Not only will these reactions constitute important developments in the field but the product structures are often biologically relevant, thus lending the chemistry to important synthetic applications. Accordingly the design and implementation of a new and broadly applicable methodology to solve the enantioselectivecatalytic alkylation reaction would have a significant impact on organic synthesis and is the focus of this proposal.'""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unlocking the Potential for Agricultural research on an EU Outmost region: boosting ISOPlexis centre' (2021-2027).

assistant: **Concept**

Agricultural RTD is important for global food security and environmental sustainability.The isUP-AgrO proposal aims to enhance the capability of the Research Centre ISOPlexis, located in Madeira, an outermost region of Portugal, to be a leading research center at the EU level in Sustainable Agriculture and Food Technology.ISOPlexis participates with high success in national research projects and programs participates in the Network of Genetic Banks FAO, AEGIS, and ECPGR programs, and plays a leading role in the implementation of the Regional Smart Specialization strategy priority domain for Agriculture, Food, and Bioeconomy, and its goals. However, it has not been able to reach a visible position at the European level. It is now the right moment to increase the centre´s internationalization, allowing it to participate in joint international consortiums and research projects.The isUP-AgrO proposal joins two research centres from Spain (INRA - CSIC), Italy (UNIPR), and a Portuguese innovation company (Saturntech) with the common goal of improving the research and coordination activities of the ISOPlexis - Centre of Sustainable Agriculture and Food Technology. The isUP-AgrO will offer training for young/senior scientists, develop administrative/research management skills, and foster networking through joint research, expert visits, training schools, staff exchanges, workshops, and conference attendance.  The isUP-AgrO overall methodology is based on new approaches and strategies to study and improve the sustainability of the Food Production System, in this case, in the traditional vineyards of Madeira. The isUP-AgrO strives for research excellence and extensive networking to elevate the ISOPlexis Centre (University of Madeira) to be an EU reference in this field. Success w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Spatial earth observation monitoring for planning and water allocation in the international Incomati Basin'.

assistant: **Innovation**

This project proposal focuses on water resources allocation and the identification of historical and current water use and high resolution monitoring of several water resource indicators on a weekly basis. For this purpose an operational earth observation system will be developed which includes a website with weekly updates of water resource data on water use. This system can be linked to GEOSS (Global Earth Observation System of Systems) in order to make data accessible for multiple users. The main data generated on a weekly basis as a result of this project are:-Water use and evaporation-Rainfall-Land use-Soil moisture-Biomass productionThese five parameters are the basic inputs for water accounting, which is a relatively new concept that can contribute to better water allocation, verification of water use and sustainable water utilization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enhanced oxygen delignification of wood pulp by advanced sonic technology' in the context of a Fifth Framework call.

assistant: **Objectives**

In this project, an innovative and novel sonic technology is proposed which will fulfil this need by dramatically improving the utilisation and effectiveness of oxygen for wood pulp and paper bleaching. The sonic agitation process causes strong cavitation and acoustic streaming which is a highly efficient and effective driving force for mass transport and improvements in mixing and process kinetics through the generation of smaller gas bubble sizes and through the acoustic-mechanically supported detaching of lignin from cellulose fibres. Furthermore, a method of evaluating mixing quality in pulp mixers will be developed for an optimised process control. The European pulp and paper industry was and still is faced with economic challenges from a competitive world market ruled by the USA in the manufacture of pulp and paper products. Therefore considerable market demand can be projected for a technology, which provides a cheaper, more efficient and environmentally benign means of delignifying pulp. With more than 1.200 wood pulp bleaching operations in the EU, a market niche is waiting for a process, which can accomplish this. In addition to the benefits for wood pulp and paper bleaching, the sonic process may be applicable to chemical pulping, processing of recycled paper products, cloth fibre bleaching, waste water treatment and other industrial processes where ...
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Sustainable PRImary PRInted Cells Eco-designed for intelligent packaging'.

assistant: **Innovation**

As we transition towards digital societies and industry 4.0 technology, the exponential rise of power hungry Internet-of-Things (IoT) sensing, actuating and communicating modules, will drastically increase the demand of primary consumer batteries in the near future. This raises an environmental alarm regarding their resource intensive production and the generation of hazardous electrical and electronics equipment waste (WEEE) after the end of its operation lifetime (EoL). SPRICE proposes a paradigm shift in the way primary batteries are conceived by implementing a circular economy strategy and by eco-designing for sustainability based on the device entire life cycle of such as  material evaluation, manufacturing, utility and EoL. This work presents a sustainable primary battery for intelligent packaging application on cardboard box. The sustainable aspects entailed are selecting benign and abundant materials that are compliant with low-energy printed battery manufacturing and with the cardboard box established recycling infrastructure (paper waste stream). The proposal is undertaken at Fuelium, a Spanish company specialised in the development and commercialization of sustainable paper-based batteries. The project involves supervision by (Dr. Juan Pablo Esquivel, an expert in the field of paper-based fuel cell and sustainable battery development and Fuelium cofounder and scientific advisor. An additional secondment is planned at the institute of microelectronics in Barcelona, at Dr. Neus Sabate´s group, who is another expert in autonomous systems research. At the end, SPRICE will present a full demonstrator integrated on cardboard and meeting all sustainability and performance requirements. The revolutionary approach of this proposal will provide the departing point for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Efficient Smart sysTems with enhAnced eneRgy Storage' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

E-STARS project aims at developing enhanced sensing and communication capability on an autonomous smart micro system powered by a new 3D high capacity integrated micro battery. According to the experts, the market of wireless smart sensors should generate revenues more than 5 billion euro in 2011 (source: http://www.rfidjournal.com). Faced with such future strong technical and economical impact, it is of strategic importance to maintain the Europe¿s leadership in these domains.  Considered as an RandD topic of high relevance in such domain (EpoSS Strategic Research Agenda), the energy-management, scavenging and storing techniques aspects will be particularly investigated by the E-STARS project.<br/>The objective is to reach higher energy-management and autonomy performance packed in a smaller volume. The innovative 3D architectures micro batteries will increase by 5 to 10 the battery capacity (from 100 µAh/cm² to 1 000 µAh/cm²) and power (from 5 mW/cm² to 50 mW/cm²) compared to traditional solutions. To do so, the consortium will investigate completely new deposition processes for micro battery layers such as Chemical Vapor Deposition (CVD), electrospraying and electrodeposition in order to obtain 3D higher aspect ratio aspects. <br/>The consortium involves well known complementary research partners (CEA, TUDELFT and UNIVERSITY of PARIS XI), industrial partners (MOTOROLA, STMICROELECTRONICS), as well ad SME¿s (BIOAGE and CORA TINE TEORANTA) from 5 EU countries. <br/>As a STREP project, E-STARS addresses clearly the objective 6 of challenge 3 of the ICT call 2 : Micro/nanosystems. The targeted applications within the project are : wearable intelligent micro sensors, wireless networked sensors associated to an intelligent data to internet platform and innovative nanogravi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ULTRASOUND TECHNOLOGY FOR BETTER QUALITY AND SHELF LIFE OF FISHERY PRODUCTS' (ULTRAFISH).

assistant: **Concept**

The project aims at improving the quality and quantity of fish products by implementing ultrasound into the current processing lines of fresh fish. This technology is well-known to have significant effect on the rate of preservation, reducing the microbiological activity (99.9%) at low temperatures (0-3C), decreasing the processing times and costs, eliminating post-treatment of water waste and consuming less energy. Ultrasound is a green and non-toxic technology that will contribute to increase the commercial shelf life of fish products and will help fish processing companies in Europe to increase their production capacity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Personalized Information Platform for Life and Health Services' in the context of a Sixth Framework call.

assistant: **Objectives**

The PIPS project will make a significant step forward in the processes for healthcare (HC) delivery to the European Public by means of creating a new Health and Life Knowledge and Services Support Environment. This will improve current HC delivery models while creating possibilities for HC professionals to get access to relevant-updated medical knowledge and the European citizens to choose healthier lifestyles. The objective is to encompass the entire set of business processes, professional practices, and products applied to the analysisand preservation of the citizen's well-being using the latest innovations in ICT. The project joins HC suppliers, citizens, public organizations, food/drug industry and services, researchers, and health related policy makers, that are affected by the health status of individuals and the population, to create a dynamic knowledge environment that nourishes the system, and gives added value feedback for personalisedand contextuallzed knowledge and services to improve the European public's welfare. In the PIPS scenario each actor is a supplier and receiver of personalised knowledge. This includes both explicit and implicit knowledge management based on traditional and new approaches to knowledge discovery out from current medical practice, evidence based medicine, and disparate knowledge sources from health/nutrition domains.PIPS results will enable:- HC Professionals to deliver just-in-time personalised and prevention-focused HC services compliant with the Citizen's personal health state, preferences and ambient conditions- Citizens to make informed decisions about therapies and nutrition at any time/place according to the real-time evaluation of their health state- HC Authorities to improve risk management of HC systems- Actors in the HC d