RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Chiral catalytic membrane reactor for high efficient preparation of enantiopure compounds'.

assistant: **Innovation**

Chirality is a universal phenomenon in nature. Many pharmaceuticals, nutraceuticals, and agricultural chemicals have their own stereoisomers, with each enantiomer showing a unique biological activity. The production of pure enantiomer is therefore essential especially for medication safety and efficacy. In this project, a novel membrane reactor technique is proposed for efficient production of important chiral intermediates in the pharmaceutical industry and agrochemistry. New homochiral metal-organic framework (MOF) materials and membranes will be integrated with the latest development in ceramic hollow fibres, in an objective of generating a catalytic membrane reactor (CMR) coupling asymmetric synthesis and enantioselective separation into a single micro-tube. Such CMR to be developed is composed of a homochiral MOF membrane layer supported on a ceramic hollow fibre substrate with a unique dual-structure, i.e. a porous functional layer for preparing the MOF membrane and a finger-like layer where MOF-based asymmetric catalysts can be deposited. Reactants fed to the tube side of the hollow fibre substrate will be converted into desired enantiomer and by-products. Meanwhile, the desired enantiomer recognized by the MOF membrane materials coated on the exterior functional layer will adsorb on the membrane surface, followed by diffusing through the membrane for enantioselective separation, with the by-products rejected by the membrane and collected at the outlet. Such an original interdisciplinary approach of producing chiral intermediates involves the latest multidisciplinary knowledge and techniques in material, chemistry, membrane, chemical engineering and catalysis, and has not yet been attempted to date. Moreover, the successful delivery of this project allows possibl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Streamlining Environmental Impact Assessment complex networks to integrate new EU environmental policies' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

In response to climate change, the landmark Paris Agreement established a set of goals to achieve climate neutrality and limit global warming. To help investors and companies contribute to these goals, the EU adopted a taxonomy for sustainable activities, and in line with it, investments must not cause significant harm, as indicated by the Recovery and Resilience Facility Regulation. Since its inception, the Environmental Impact Assessment (EIA) procedure has aimed to minimize the impacts of projects that could significantly damage the environment. Certainly, there are recognized weaknesses in the EIA, but its fitness to address complex environmental challenges such as climate change is unmatched. Considering the EIA importance in ensuring the scaling up of sustainable energy-related investments, NetDEAL focuses on providing innovative and easy-to-use methods to improve EIA worldwide and combines policy analysis and EIA assessment data into complex networks. First, I will analyze models of impact assessment (IA) legislation that can make recommendations about how IA can change to fit the global effort to tackle the energy and resource crises. Second, I will expose best practice models and investigate, through network-related statistical analyses, the collaboration links established in each EIA stage, which are behind successful projects from the perspective of productivity, circular economy, adaptation to climate change and reaching the goal of zero net emissions. Third, using Exponential Random Graph Models, I will explore the dynamic interaction between EIA stakeholders to diagnose the organizational structures and factors that strongly influence these projects. Lastly, I will create an integrated multilayer framework to improve the EIA's effectiveness. The findings w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enhanced In Situ Bioremediation for Contaminated Land Remediation' under Horizon 2020.

assistant: **Concept**

EiCLaR, as a EU/China consortium, will develop scientific and technical innovations for in situ bioremediation technologies that will be directly developed into industrial processes for the rapid efficient cost-effective treatment of a range of environmental pollutants such as chlorinated solvents, heavy metals, pesticides, etc. These technologies (Electro-nanobioremediation, innovative Bioaugmentation, Bioelectrochemical remediation, Enhanced phytoremediation) will enable bioremediation approaches to expand their range of applications to industrial sites and waters that contain complex, high concentration pollutant mixtures. This project will move our proof-of-concept level advances to industrial commercial processes through laboratories studies to refine the processes and to explore the scientific base and scale-up techniques and field demonstrations.  Our recent advances in nanobioremediation will be enhanced by studies of the critical microbial component and the use of electrochemical processes to increase the degradation rate and biocatalyst lifetime. The innovative bioaugmentation is based on a recently discovered bacteria capable of degrading some chlorinated solvents efficiently under aerobic conditions.  The Bioelectrochemical system will speed up the anaerobic degradation of pollutants when aeration is not feasible.  The enhanced phytoremediation will benefit from the synergistic effect of fungi and electrokinetic nutrient dispersion. These environmental sustainable and low impact depollution methods will provide service companies with the tools to manage contaminated soil and water and improve environmental quality at over a million sites throughout Europe and China. These companies will be able to grow by increased personnel and revenue while improving biodi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'An in-vivo Screen for the Identification of Leukemia-Promoting Factors'.

assistant: **Innovation**

The proposed research aims to identify and characterize factors conferring leukemic properties to hematopoietic cells. This screen will be based upon a murine leukemia model I have developed in my time at the Salk Institute (La Jolla, CA) these mice express a fusion of RARalpha with three FKBP12 Rapamycin-regulated dimerization domains” FKBP12 F36M (F3-RARa). These F3-RARa TG mice, though healthy, exhibit a “preleukemic” state that is more accessible to transformation by cellular factors, such as activated cytokine receptors. (Sternsdorf et al, 2006). At low frequency, these mice spontaneously develop myeloid leukemia with APL features. From these leukemias I want to identify leukemogenic factors. Freshly expanded Leukemia cells will be used to generate a retroviral cDNA library. Initially, I will use this library to transduce non-transplantable murine cell lines and test, which factors convey transplantability. In the following, I will transduce /transplant pre-leukemic bone marrow from younger F3-RARa mice. This should lead to leukemias, which will be tested, isolated by cell sorting, according to presence of viral integrate (GFP). Leukemias will be FACS-isolated by phenotype (GFP, Surface markers). The integrated retroviral vectors will be isolated by PCR. The goal of this analysis is to identify and characterize novel cellular factors, involved in the process of leukemia development. This will enable me to identify novel potential targets for therapy. I am an experienced scientist in the earlier part of my career: after spending nine years in the US, I am returning to the European Union. A Heisenberg Fellowship (Germany) made this possible. This fellowship, though prestigious, covers only a small amount of funding besides my salary. Therefore I consider the IRG a cr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Unlocking the Antitubercular Mode of Action of Asperterpenoid through Total Synthesis' (Asperterpenoid) under Horizon Europe.

assistant: **Objectives**

The rise of multi-drug resistant strains of Mycobacterium tuberculosis, the pathogen responsible for the infectious disease tuberculosis, calls for research into novel antitubercular scaffolds and targets. Asperterpenoid is a rare sesterterpenoid with a unique and highly complex 5/7(3)/6/5 ring-fused carbon skeleton that strongly inhibits tyrosine phosphatase B, a virulence factor protein secreted by M. tuberculosis that aids human host infection. To date, total synthesis of asperterpenoid has not been accomplished. We propose a modular synthesis of asperterpenoid from biorenewable sitolactone using a key intermolecular reductive titanium mediated Giese addition reaction. The scope of this privileged reaction will be expanded by investigating selected epoxide substrates and Michael acceptors. We anticipate that the synthetic strategy to asperterpenoid can be extrapolated to prepare variecolin, a structurally related sesterterpenoid that has been subject of several studies but never reached by chemical synthesis. Based on its structural similarity to asperterpenoid, we expect that variecolin will also exhibit antitubercular activity. We plan to study the known antitubercular activity of asperterpenoid by structural diversification and its mechanism of action by a chemical biology tools such as molecular imaging. We also plan to test variecolin for antitubercular activity. The action is expected to contribute to new synthetic tools and strategies to prepare rare sesterterpenoid natural products, a better  understanding of the promising antitubercular properties of asperterpenoid, and to demonstrate that variecolin exhibits similar bioactive behaviour.


**Keywords:** Sesterterpenoid, Variecolin, Radical Chemistry, Photo-Redox Chemistry, Asymmetric Synthesis, Chemical Biol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Joint European and Latin American Research Network on Diabetic Microangiopathy' under Seventh Framework.

assistant: **Concept**

The WHO estimates that the metabolic disease diabetes will become the leading cause of morbidity and premature mortality by the year 2020, severely affecting both developed and developing countries. Diabetic microvascular complications affect eyes, kidneys, and nerves.  Hyperglycaemia is the most important risk factor for diabetic microangiopathy. However, the mechanisms by which poor glucose control mediates functional and structural changes are poorly understood. New insight into the key pathogenic pathways is crucial for novel therapeutic strategies to prevent and cure these diabetes-associated microvascular complications.EULAMDIMA builds on a novel and unique international focus on microvascular mechanisms as outlined in the FP-7 programme DIAMAP. It has a multidisciplinary and translational approach combining state-of-the-art platforms of (pre-)clinical expertise with expertise in vascular or neuronal biology, novel model systems, and endothelial targeted therapeutic strategies. It fosters the exchange of knowledge by making use of international complementary expertise and provides access to fundamental genetic and environmental data.The present scheme contributes to the construction of new and the enhancement of existing networks. It builds on the UMCG-UHEI cooperation established within the International Research Training Group  GRK880 “Vascular Medicine” as well as the cooperation between UMCG and the Latin American partners UNAM and UNAB within the Abel Tasman Talent Programme.EULAMDIMA ultimately aims to define novel targets for the treatment of microvascular complications related to diabetes to help alleviate the immense burden that is posed on both individuals and societies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Deciphering the tumor-immune-microenvironment profile and organization within the tumors of melanoma patients undergoing immunotherapy' (MelImmuneOrg).

assistant: **Concept**

Cancer progression is a complex process that depends on the interplay between tumor cells, tumor microenvironment, and the immune system. Inhibiting immunosuppression is beneficial for cancer patients. Although these therapies are promising they are successful only in part of the patients. Tumors are composed of distinct cell types with different phenotypes, that influence the efficacy of immunotherapies. Therefore, in order to better understand tumor biology and response to treatment, it is necessary to profile protein expression while preserving spatial information. Multiplexed Ion Beam Imaging by Time of Flight (MIBI-TOF) is a method in which antibodies conjugated to metals are used to simultaneously visualize dozens of proteins in intact tissue specimens by secondary ion mass spectrometry. Here we suggest to uncover the immune profile and organization within the tumors of melanoma patients undergoing immunotherapy using MIBI-TOF. My first objective is to characterize the tumor-immune microenvironments to understand how these are structured across patients and discover predictive features of response to immunotherapies. My second objective is to analyze the intratumor heterogeneity (ITH) of melanoma patients by exome sequencing. I will examine whether there are genetic correlates between ITH, immune microenvironment and response to therapy. Finally, my third objective will be the manipulation of individual hits to test their functional significance in tumor-immune architecture in murine models. By joining Dr. Keren’s lab that masters the MIBI-TOF technology, I will acquire this state-of-the art technique, as well as develop lab management and organization skills, and I will meet leader scientists from the immune-oncology field. This proposal will promote my competiti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Improvement in quality control of rubber-covered rollers' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The aims of the proposed research are to satisfy the need for economical measurement of the surface finish of rubber-covered rollers, evaluation of bond integrity and study of roller friction to improve understanding of the effects of surface treatments and rubber compound upon overall roller performance. At present instruments for surface finish are expensive, bond evaluation is uncertain and there is a lack of information on friction. The main tasks are: (i) development of new test methodology for surface finish; (ii) evaluation of new bond integrity tests; (iii) study of roller friction to improve understanding and product performance. A successful outcome should improve test protocols, produce new prototype instrumentation, assist adoption of water-based bonding agents so leading to a healthier factory environment, and help reassess rubber scrap disposal. Direct benefits to roller manufacturers would be fewer rejects, fewer delays and the ability to offer better guarantees of performance. Cost savings of 20% may be possible in a European sales market of 500MECU per annum, with further benefits accruing to related sectors concerned with recycling and the environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Algorithmic Verification of String Manipulating Programs'.

assistant: **Concept**

String is among the most fundamental and commonly used data types in virtually all modern programming languages, especially with the rapidly growing popularity of scripting languages (e.g. JavaScript and Python). Programs written in such languages tend to perform heavy string manipulations, which are complex to reason about and could easily lead to programming mistakes. In some cases, such mistakes could have serious consequences, e.g., in the case of client-side web applications, cross-site scripting (XSS) attacks that could lead to a security breach by a malicious user.The central objective of the proposed project is to develop novel verification algorithms for analysing the correctness (esp. with respect to safety and termination properties) of programs with string variables, and transform them into robust verification tools. To meet this key objective, we will make fundamental breakthroughs on both theoretical and tool implementation challenges. On the theoretical side, we address two important problems: (1) design expressive constraint languages over strings (in combination with other data types like integers) that permit decidability with good complexity, and (2) design generic semi-algorithms for verifying string programs that have strong theoretical performance guarantee. On the implementation side, we will address the challenging problem of designing novel implementation methods that can substantially speed up the basic string analysis procedures in practice. Finally, as a proof of concept, we will apply our technologies to two key application domains: (1) automatic detection of XSS vulnerabilities in web applications, and (2) automatic grading systems for a programming course.The project will not only make fundamental theoretical contributions — potentially so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Process of GaN-on-diamond with Si-based nanolayer SAB technology' in the context of a Horizon Europe call.

assistant: **Objectives**

GaN substrate materials have been increasing the demands of applications such as wireless communications, super-high computing, and power-management IC. The growing demands create substantial challenges for both the development of new semiconductor materials and their thermal power management in very large-scale integrated circuits. The highly localized Joule self-heating at the drain edge of the gate degrades the electrical performance and reliability of integrated circuits by introducing the device's channel thermally activated degradation mechanisms. To improve the radiation effect, the localized device's drain and channel regions heat generated in the active region of Si-substrate GaN high electron mobility transistors (HEMTs) device must be efficiently restrained. Third-generation semiconductor SiC and diamond, their appearance has improved high power reliability and performance, however, this direct growth requires an AlN or a SiN nucleation layer and suffers from the cost-effective large wafer. Besides, to date, GaN devices are mainly fabricated on sapphire, Si/SiC substrates having thermal conductivities of about 0.5, 1.5, and 4.0 W/cm·K, but the heat generated in GaN-on-diamond structure devices can be easily dissipated due to the excellent thermal conductivity characteristics of a diamond (thermal conductivity: ~22 W/cm·K). In order to conquer the growth of AlN or SiN GaN heterostructures on high poly- or micro-crystalline diamond and realize high-performance heat dissipation, a novel diamond growth on Si process using liquid gallium and titanium at low atmospheric pressure and a SAB Si-based nanolayer integration GaN-on-Si technology have been proposed. In this proposal, commercial GaN-on-Si and fabricated Diamond-on-Si were bonded with an extraordinarily low