RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'SBMA as a model of polyglutamine diseases: generation of a suitable cell system to study the post-transcriptional modifications of mutant androgen receptor and to discover potential therapeutic drugs' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Accumulation of toxic aggregation-prone protein into inclusions and aggregates is the hallmark of most neurodegenerative diseases, a broad class of disorders including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and polyglutamine diseases. In this proposal, using SBMA as a model of neurodegenerative polyglutamine-related disorder, we intend to move a step forward expanding knowledge of the neurodegeneration. In particular, we will provide a suitable model system such as differentiated iPSCs from SBMA patients to study molecular mechanism and to find out potential therapeutic drugs for neurodegenerative diseases. To define the disease-phenotype of differentiated iPS cells we will take advantage of specific features of SBMA disorders: the ligand-dependent toxicity of expanded AR. The ligand binding induces many modifications of AR protein such as phosphorylation. Since phosphorylation of mutant AR is an important determinant of SBMA pathogenesis, we will also characterize the impact of cyclic adenosine monophosphatate (cAMP)-dependent protein kinase A (PKA) signaling on the mutant AR toxicity. Then, we will use this information to identify agents that promote such modifications to find out potential therapy. Therefore, in order to develop treatment for SBMA, we will test the effect of neuropeptides that stimulates the generation of cAMP and activation of PKA, to target SBMA spinal cord.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project '3D-printing of PARTiculate FORMulations utilizing polymer microparticle-based voxels' (3DPartForm) targeting Horizon 2020.

assistant: **Abstract**

New polymer materials are necessary to match the demand for highly integrated, multifunctional, responsive systems for sensing, information processing, soft robotics or multi-parametric implants. Both establishedmaterial design concepts based on lithography, and emerging engineering efforts based on additive manufacturing (AM) are currently not able to fully address the need for topologically complex, multifunctionaland stimuli-responsive polymer materials. This proposal aims at establishing a radically new approach for polymer material design, rethinking AM on both material and process level. Here, functionality will be alreadyembedded at the building block level to emerge into larger scales. The exact methodology relies on polymer microparticles as a novel material basis with arbitrary geometry, function, mechanics and responsiveness.These microparticulate formulations will serve as predefined, voxel-like building blocks in AM yielding hierarchical assemblies with spatially defined voxel position and programmable, adaptive properties, which clearly go beyond existing functional material classes. With that, 3DPartForm will address the current lack of additive manufacturing providing multifunctional, stimuli-responsive materials, in which not only strongly different, but most importantly functional building blocks with intrinsic time axis will be processed into true 4D-polymer multimaterials. Products emerging from this approach will reach a previously unknown level of system integration, where optical transparency, electric and thermal conductivity as well as diffusivity and mechanical rigidity will become spatiotemporally tunable at single-voxel level. Coupled sensing and actuation operations will be realized by processing, transforming and manipulating single or comb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sundim-photovoltaic street lighting system' under Fourth Framework.

assistant: **Concept**

The project aims at developing an autonomous external lighting system for sites distant from a distribution network of electricity. This system will compri se: - a photovoltaic generator, - a gas-discharge lamp with high flow, - a l ow cost and highly reliable electronic system allowing rational management of t he electric power in order to minimize the energy consumption according to the need for illumination. The innovative aspect mainly lies in the design of th e component allowing the power variation, and in its command/control unit. I n Europe, such a system will be profitable on sites distant of more than one ki lometer of a network and profiting from a sufficient sunning, which is the case of several hundreds of listed sites. In the developing countries, in particula r in the Maghreb, the market is considerable. Six companies of four countrie s joined to conclude this project: two manufacturers of luminaries, two compani es of the sector of electronics, a photovoltaic engineering company, and a cell ular telecommunication company. The research centers have competences in power electronics, in solar energy systems, in lighting and in measurements. The p roject aims to test in two years eight realistic technological solutions, in Fr ance and Greece, and to evaluate their performances before introducing the most interesting products on the market, in four years.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Extending the European archaeology web over Bulgaria, Romania and Poland' under Fourth Framework.

assistant: **Concept**

The networking and internationalisation of existing academic resources,historical and cultural achievements, as well as the research efforts of the academic community in the field of Archaeology using computer, information and communication technologies is a recent trend with a rapidly growing impact on archaeological research, management and education. In recent years, Internet services have completely changed the way scientists work: e-mail, usenet, FTP and finally WWW architecture now allow scientists to collaborate on distributed resources, e.g. databases and exhibitions over the WWW. Although the countries of Eastern Europe have an important place in the historical and cultural development of Europe, they do not currently have substantial participation in this process of intensifying information exchange, due to their past closedness and current economic problems. There is thus the spectre of an ever widening 'information gap' between the affluent countries of north-western Europe and those countries struggling at the margins.ArchTerra aims to help redress the current imbalances in access to European networking facilities for professional archaeologists from Bulgaria, Romania and Poland, and to provide the impetus for an active expansion of archaeological Internet communication and information services both within CEC and between EU and CEC. The project is implemented as a research network bringing together computer scientists and archaeologists from five EU countries (the Netherlands, United Kingdom, Italy, France and Germany) and three CEC (Bulgaria, Romania and Poland), and encompasses tasks and objectives in four areas:· technical installation (computer hardware and software, networking infrastructure)· transfer of expertise (technical workshops, extended visit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Migration pathways into deep-sea chemosynthetic environments'.

assistant: **Objectives**

The MigPat project aims to trace pathways of migration of molluscs into and between deep-seach emosynthetic ecosystems, using evidence from the fossil record. Chemosynthetic ecosystems are characterized by their dependence on geochemical energy sources, largely hydrogen sulphide and methane, rather than photosynthesis, as most other marine and terrestrial ecosystems. Such ecosystems are known from hydrothermal vents, cold hydrocarbon seeps, sunken whale carcasses, and sunken driftwood. We will use molluscs as a test case because they are abundant and diverse in fossil and recent chemosynthetic ecosystems and they have been used in most molecular biological studies on migration pathways into these habitats. This will make our results comparable to those of earlier studies.To achieve our aims, we will use the extremely rich and diversified fossil record of chemosynthetic ecosystems in Washington State, USA, that spans the last 50 million years. We will compile a database of molluscan species in this area, which will comprise data on their taxonomy, stratigraphie occurrences, habitats, and ecology, as a base for all further investigations. To assess migration pathways we will determine relationships between species and compare their habitats, including recent species living at vents, seeps, whale-, and wood-falls just offshore the study area. In addition, we will analyse the ranges of species in geological time.By comparing the ranges of species from chemosynthetic habitats to those from normal marine habitats we can test th e hypothesis that deep-sea vents and seeps serve as a refuge for 'ancient' taxa, and an alternative hypothesis that rapid bursts of adaptation and extinction have occurred. We will also assess how many of the species found in fossil chemosynthetic loca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Filament branching during infection by a human opportunistic fungal pathogen' (BranchOut), addressing dissemination and exploitation.

assistant: **Impact**

Fungal infections result in millions of deaths and billions of superficial infections each year. Morphological transitions are critical for fungal virulence. Filamentous hyphal branching is affected by nutrients and suggested to be altered during infection. The aim of this interdisciplinary project is to determine the importance of branching in the human opportunistic fungal pathogen Candida albicans. Specifically, how is branching controlled and regulated in time/space during infection? Towards this goal, I will investigate branching at the molecular/cellular levels, and use genetic/molecular perturbation to delineate functions and requirements of branching. Live-cell imaging will be used to determine the frequency and position of hyphal branching, as a function of infection-relevant conditions, including growth on/in different stiffness substrates, physical confinement, nutrients and gaseous environment. This will help us to characterize the biophysics of branching and to understand the spatial regulation of the process. To address how branching isaffected by host cells, this process will be followed in co-culture with reconstituted human epithelia To determine at molecular/cellular levels the critical processes and components that localize to incipient branch sites, I will use different fluorescent reporters. Targeted and unbiased, genetic/molecular approaches will be used to probe the functions and requirements of branching and selected mutants will be examined in mice. Using optogenetics, I will investigate perturbation of branching by induction of de novo branching. In summary, this interdisciplinary project, that takes advantage of cutting-edge imaging, molecular approaches and biophysics tools, will shed light on the importance and regulation of branching during
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Study of the functional role of Alveolar Macrophages in vivo' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The lung is a fascinating tissue at the level of immune regulation. As barrier to the outside world it is in constant contact with innocuous environmental antigens, but is also the entrance site for many pathogens. Importantly, loss of immune tolerance against environmental antigens, including pollen and house-dust-mite antigens, can cause severe allergic asthma. Dendritic cells (DCs) and Macrophages (MFs) play an essential role in regulation of immune responses. Thus lung DCs and lung MFs appear to mediate two seemingly incompatible functions: maintaining tolerance against harmless environmental antigens while retaining the capacity to response powerfully to invading pathogens. This CIG project is based on the hypothesis that the different functional tasks performed by DCs and MFs in the lungs are in fact mediated by distinct subsets of DCs and MFs. Unfortunately current available research tools cannot properly address the contribution of the individual DC or MF subsets in the regulation of pulmonary immune responses. Therefore, this project proposes to combine state-of-the-art cellular and molecular techniques to generate innovative research tools which will allow to unambiguously study the specific role of the major lung MF subset, i.e. the Alveolar Macrophage (AMFs). We will first identify AMF-specific genes and then generate two knock-in mouse models to unravel the role of AMFs in vivo. This study should lead to a better understanding of the functional role of AMFs in the regulation of pulmonary immune responses, including allergic asthma, airway tolerance and defense against pathogens, which ultimately could lead to the design of more efficient immune intervention strategies to fight lung diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PORTABLE KIT FOR DETECTING TRAPPED AND BURIED PEOPLE IN RUINS AND AVALANCHES' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Although avalanches, earthquakes and collapsed buildings are claiming an increasing death toll due to urbanisation, climate change and tourism, Search and Rescue (SAR) operations are limited and expensive. Even research efforts for Search and Rescue services are relatively unimportant due to the specific and therefore limited market for existing products. The main limitations of existing SAR methods are their inefficiency, time involvement and costly as they are very directional and limited in range and accuracy. In addition, their usage is complex and requires intense training and sophisticated methodology or even resorting to a specialised team. Therefore, there is an urgent need for developing a unique, easy-to-use, cost-efficient, safe and reliable tool in order to locate victims who are buried under debris or snow, providing accuracy of their position in a swift way.As experiences from disaster situations show than most of the victims carried mobile phones with them, the aim of the RescueCell project is to develop a novel accurate location system based on mobile signal measurements in order to create a cost-effective and portable kit for emergency search services, easy to be to be installed and used. The SMEs participating in this project will greatly benefit from exploiting the RescueCell application for the location of cell phones worldwide. The RescueCell system is expected to lead to significantly faster searches in SAR missions resulting in finding more survivors, and also in reducing the related SAR cost proportionally. Apart from money savings due to the lower SAR operation cost, and reduction in hospitalization costs, there is also the value of a life or health that cannot be quantified. If this technology saves lives, this research will undoubtedly be wort
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Functional Biomarkers as in vitro diagnostic tools for managing patients with chronic disease' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The aim of this proposal is to establish a business plan for the development of a new class of Functional Biomarkers as in vitro diagnostic tools for managing patients with chronic disease. The proof of concept will be established by focusing on substrates of the X-prolyl dipeptidylpeptidases (DPP), a family of pleotropic enzymes that cleave the N-terminal two amino acids of proteins. There are >30 known substrates for DPPIV, the best characterized member of this family. Importantly the catalytic activity of DPPIV results in the conversion of agonist ligands into antagonist or non-functional proteins.In the context of our funded ERC project, we have provided the first in vivo evidence of DPPIV-mediated cleavage of the chemokine interferon-induced protein 10 (IP-10 or CXCL10) [Casrouge, JCI 2011]. These initial observations have recently been validated, conclusively demonstrating the ability to predict treatment failure in chronic HCV patients (p-value <0.001 for antagonist CXCL10 and negative predictive value = 93.5%).Based on the important role of DDPIV in disease pathogenesis and following from our findings, there are two ideas that we wish to develop further as proof of concept for ‘Functional Biomarkers’ in the management of patients. First, we wish to evaluate the market needs for developing a privately run SME, aimed at providing theragnostic testing useful for stratification of chronic HCV patients. We will also examine the potential value of applying these in vitro diagnostic (IVD) tools in other disease settings in which DPPIV and/or CXCL10 have been identified as a predictive biomarker. Second, we aim to extend our repertoire of assays to include other disease relevant DPPIV substrates.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Measure of the Ecological influence in Epigenetic-mediated Learning and memory formation in the Honeybee' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Understanding the mechanisms of species adaptation within ecosystems in perpetual change is one of the greatest contemporary scientific challenges. Pollinating insects such as honeybees are particularly sensitive to the changes brought by the intensive mono-agricultural practices and insecticide exposure. Anticipating the widespread decline of bees requires a better understanding of the molecular pathways that affect their cognition such as memory, within their natural habitats. The unique field based behavioural experiments used in this proposal will provide memory and adaptation indexes from honeybees of various ecological and geographical places in Greece. It will help monitoring bee heath, improve beekeeper practices and consequently, participate in a better pollinator European management strategy. The recent discovery of epigenetic mechanisms that can explain phenotypic plasticity of honeybee holds great promise in understanding epigenetic-mediated adaptation. This proposal will also use state-of-the-art ‘-omic’ and super-resolution microscopy techniques to determine the brain cells type associated with the epigenetic dynamic occurring during memory formation in bees. These results will greatly participate to the understanding mechanisms of brain plasticity. The multidisciplinary approach of this proposal is feasible thanks to the unique combination of the researcher expertise on epigenetic study in social insects together with the extensive competence for the characterisation of the molecular pathways involved in memory formation of the host lab. Moreover the two partner organizations and their network will bring additional expertise and infrastructure for honeybee management used in this proposal. Together, the results of this proposal will generate new health in