RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Decoding and Targeting Treatment-Resistant Metastatic Neuroblastoma' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

The childhood cancer neuroblastoma (NB) is a major challenge in pediatric oncology, and children with relapse have a very poor prognosis due to treatment-resistance at metastatic sites. There is an urgent need to better understand NB treatment resistance to inform the design of novel therapeutic strategies. However, current models do not mimic relapsed human NB in its most common metastatic niches in the bone and bone marrow. We recently developed advanced patient-derived and humanized NB in vivo models and 3D tumor organoid models which are excellent tools for preclinical drug testing. Here, we aim to further develop and exploit these models, investigate mechanisms of NB metastatic treatment resistance/relapse, and target relapsed NB with combination therapies. First, we will develop patient-derived in vivo and ex vivo models of relapsed NB in the human metastatic bone marrow niche exposed to standard-of-care chemotherapy treatment. These models will be exploited to investigate mechanisms of metastasis and treatment escape upon therapy and at relapse. We will integrate NB and stromal cell lineages, cell states and molecular details with phenotype and drug response, and elucidate NB tumor cell plasticity and clonal evolution. The mechanistic data and our new models will help us to identify novel therapeutic targets and compounds targeting relapsing and resistant NB, which we will validate experimentally. The project will lead to a deeper understanding of NB metastatic treatment resistance and identification of novel cell state-directed treatments to target resistant and metastatic disease.My combined background in clinical medicine/pathology, in vivo/ex vivo modeling, NB chemoresistance, and preclinical drug testing coupled with development and application of state-of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on '2 STAGES NEW TECHNOLOGY DRYER FOR PLASTERBOARDS'.

assistant: **Concept**

The aim of the project is to convert an existing plasterboard dryer to two-stage drying". It consists in a drying energy reduction while the electrical consumption is constant. The target of energy saving is of about 20% of natural gas with a better quality for plasterboards. Reliability level and safety level of the new equipment must be at least equivalent to those of the existing equipment. It is also to demonstrate the practicability and operational safety of the two-stage drying process for plasterboards, and to prove the economic efficiency in practical application, testing of components, gaining practical experience. The innovation is that in the new two-stage dryer, the heat of condensation is used for pre-drying and post-drying due to a "new type" of heat exchanger in the last zone of the drying system and this zone is heated with fresh air flowing in opposite direction to the product.L%The energy consumption during a recent steady run has been between 560 and 570 kcal/kg waterLafarge Gessi runs an industrial installation which is making gypsum wallboards in accordance with DIN 18 180. The plasterboard line has been delivered by Babcock BSH and the start up was made in September 1993 with Lafarge and Lafarge Gessi.The technical datas are :- Nominal capacity of 12.5 mm boards : 2900 m?/h- Yearly production volume : 20 Mm?- Yearly production time : 6900 hEvaporated water in the dryer :- For a plasterboard : 4.35 kg/m?- Hourly evaporated water : 12600 kg/h- Specific energy consumption : 2930 kJ:kg of evaporated water- The annual cost for natural gas is :  (12600 x 2930 x 0.026 x 6900) / 3600 = DM 1840000The dryer has a longitudinal ventilation and is divided in 3 zones.This equipment is going to be modified in accordance with the process shown in the patent DE 432
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Constructing AcTive CitizensHip with European Youth:  Policies, Practices, Challenges and Solutions' (CATCH-EyoU).

assistant: **Innovation**

The proposal will  investigate young people’s views of the EU and of their role in building the EU through their participatory practices at EU, national, regional and local levels. These issues will be examined from an interdisciplinary perspective (Political Sciences, Sociology, History, Media and Communications, Education, Psychology) as building blocks for a new and groundbreaking conceptualization and theoretical model of youth active citizenship in the EU, including “psychological” citizenship and practices of social and political engagement.To achieve this aim, the proposal will adopt an innovative approach combining traditional theoretical hypothesis testing with empirical-phenomenological analysis and allowing to integrate the perspectives of young people, as co-producers of knowledge, with those of researchers and other stakeholders. A wide range of research methods will be used including documentary and media analysis, interviews and focus groups, a cross-national longitudinal study, ethnographic case studies of participatory practices and a socially innovative intervention. These quantitative and qualitative methods will allow to develop a new, robust and cutting-edge conceptualization of youth active citizenship in the EU and  new evidence-based multilevel integrated theoretical model. This approach will offer a multifaceted understanding of the different factors influencing the perspectives of “native EU citizens” and the ways in which they engage in society, leading to groundbreaking changes in the ways in which youth engagement, participation and active citizenship are understood. Moreover, the project will provide policy makers with a set of evidence-based ideas, recommendations and instruments to integrate young people’s perspectives into various areas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Program-Specific Agents' (PROSA), addressing dissemination and exploitation.

assistant: **Impact**

In recent years, novel AI coding assistants based on large language models (LLMs) have become extremely popular in creating code. However, at least 50% of the effort of software development goes into understanding and maintaining existing software, tasks that still pose grand challenges for LLMs. This is because most maintenance tasks are related to the dynamic behavior of programs, which is insufficiently captured by learning from static code alone. Understanding how the individual pieces of a large program work together can take human experts months to years.As part of our ERC Advanced Grant “S3—Semantics of Software Systems”, we have developed innovative techniques to systematically _test_software systems, comprehensively exploring their behavior. This allows us to capture the dynamic features of inputs, outputs, and executions and train programspecific machine learning models that relate them to each other. The resulting model can then answer maintenance questions such as “What configuration input do I need to make this button green?” or “What input triggers this error message?”Our underlying research has already shown the principal feasibility of this approach, but has been limited to small examples. The question is whether these approaches scale to the multitude of features that occur during executing a complex program. This is the aim of this proof of concept proposal: To create a demonstrator of a Program-Specific Agent that is automatically trained from a nontrivial piece of software and that can answer maintenance-related questions with high accuracy.Training such an agent on even a single piece of software will require substantial resources—hence this grant proposal. However, any such trained agent will act as an expert on the software’s behavior as long as i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Spatial-temporal patterns for action-oriented perception in roving robots' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The aim of the SPARK Project is to develop completely new sensing-perceiving-moving artefacts inspired by the basic principles of living systems and based on the concept of self-organization". Sensors will be treated as devices processing signals distributed in space and also showing non linear time dynamics. Perception will be studied as a result of a spatio-temporal pattern forming process, determined by information deriving from sensors and will directly influence the particular associated motor behaviour.The whole methodology will be implemented in a new architecture, a Spatial-temporal array computer based structure (SPARC), providing a new paradigm for active perception based on principles borrowed from psychology, synergetics, artificial intelligence and nonlinear dynamical systems theory. The technical objective will be a moving artefact that will actively interact with the environment. It will integrate the sensor stimuli, will create an iconic, abstract and concise representation of the environment under the form of a dynamically emergent pattern in a SPARC based architecture and will generate a sequence of proper motor actions to reach a pre-specified target."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'indoor small-cell Networks with 3D MIMO Array Antennas' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

It is predicted that wireless network traffic will increase 1000 times in the next decade. The exponential traffic growth is not uniform across geographical areas and mainly takes place in indoor hot spots. Hence, high capacity indoor venues represent the biggest network capacity increase challenge.The recently emerged 3D MIMO technology provides a promising dimension to provide extra capacity gain in hot spots. In particular, the 3D deployment of small cells (SCs) equipped with 3D MIMO antenna arrays will take advantage of 3D distribution of user equipment (UE) in typical high capacity venues, and represents an excellent technical combination to address the indoor high capacity challenge. The 3D deployment of SCs with 3D MIMO antenna arrays faces technical challenges ranging from 3D MIMO antenna array design, performance evaluation, the lack of understanding of 3D MIMO SC network performance limits to the optimal 3D SC network deployment.The is3DMIMO project aims to address these technical challenges by assembling a team of four partners in the UK, Sweden and China with complementary expertise. During the project, the is3DMIMO consortium aims to achieve the following objectives:•characterize and model indoor 3D MIMO channels for typical indoor environments;•develop a reliable OTA antenna characterization method for 3D MIMO SCs;•characterize OTA performance in laboratory conditions as compared to real-life 3D MIMO small cell scenarios;•obtain fundamental understanding of the network performance gains achievable by 3D SCs with 3D MIMO antenna arrays;•develop techniques for jointly optimizing the deployment locations of SC access points (APs) and their 3D MIMO configurations; and•provide 3D MIMO SC network planning and deployment guidelines for typical 3D indoor scenarios
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Regulation of homoglutahione and glutathione synthesis in medicago truncatula' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content The objectives of the project is to obtain transgenic plants to study the transcriptional regulation of the genes implicated in the synthesis of glutathione and homoglutathione and to study the regulation of the synthesis of glutathione and homoglutathione under osmotic stress in Medicago truncatula. Transgenic plants expressing a reporter gene under the control of the promoters of the genes implicated in the synthesis of glutathione and homoglutathione will be constructed and analysed. In parallel, the regulation of the synthesis of glutathione and homoglutathione under osmotic stresses will be studied. The glutathione and homoglutathione content will be analyzed by HPLC, the level of the enzymes will be studied by western blot and the level of expression of the genes will be studied by Northern blot. Training content (objective, benefit and expected impact) This stay, in a laboratory which has a high training capacity, will help me to strengthen my experience in Plant Physiology and Biochemistry and to develop my competences in Plant Molecular Biology. This training will give me a good chance to find a position in Spain. Links with industry / industrial relevance (22) This project has direct applications in the human nutrition field. The production of antioxidant molecules like hGSH either as pure compound from plant cell cultures in bioreactor or as an enhanced part of the plant raw material itself is of great interest. This will be developed in collaboration with the Nestle Research Centre (Tours, France) which is the partner of the ERS 590.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A minimally Invasive surgical platform aGainst paNcreatIc and biliary Tract cancErs using cold atmospheric PLASMA' (IgnitePLASMA), addressing dissemination and exploitation.

assistant: **Impact**

Cancer is one of the major causes of death in Europe. Pancreatic (PC) and biliary tract (BTC) cancer are rare gastrointestinal adenocarcinomas with an increasing incidence particularly among the elderly and women in an ageing European population, and a poor prognosis poses major clinical challenges and public health burden. Cold atmospheric pressure plasma (CAP) has shown potential regressing various cancer types in the laboratory setting. Owing to their properties, CAP is a unique source of high concentrations of reactive radicals, electrons, ions, UV etc. that may induce various effects in living tissue. CAP has shown selectivity in where cancer cells are treated with minimal effect to healthy ones; this renders plasma suitable to treat carcinomas in very sensitive areas or organs where an unmet need to minimise damage/side-effects exists. CAP can be delivered through dielectric tubes of variable length, which makes it ideal for minimally invasive and precise laparoscopic and endoscopic operations. Despite the great promise and potential of this concept, there is no single laparoscopic or endoscopic medical platform in the market today based on CAP to treat carcinomas. This project proposes a novel solution using cutting-edge plasma technology, in-silico models, and a system-level approach. It will combine plasma with tumour multiscale simulations and will take input from pre-surgery diagnostics for in-silico model initialisation and CAP operational window determination. The developed technology will be demonstrated through in-vivo experiments, while the foundations for clinical trials and market introduction for CAP-based care of PC/BTCs will be laid out in this project.


**Keywords:** surgical instrument, medical device, cancer removal, cold plasma, multiscale mode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'An Automated HEV and EV Vehicle Fire Early Warning and Suppression System' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The developing hybrid electric vehicles and pure electric vehicles industry has led to the adoption of lithium ion batteries as the source of power. The durability and high energy density of Li-ion batteries makes them more favourable than other alternatives.  Li-ion batteries are inherently weak concerning to fire management systems. Short circuiting, overcharging, high temperatures and overheating cause thermal runaway and the release of a flammable electrolyte which makes fire extinguishing very difficult and this has stalled the progress of the HEV and EV industry. Current fire suppressing systems have failed to effectively deal with li-ion fires and Dafo Brand has come up with an innovative HEV/EVLi-ionFire project aimed at fire management and suppression for heavy commercial HEV and EV such as buses and trucks. Our proposed innovation would be 12% cheaper than current available technologies which use different li-ion fire suppression techniques. Phase 1 will focus on market study, partners search, optimisation of the technology used in internal combustion engines to suit HEV and EV standards as well as formulation of an IP management strategy in preparation for full project implementation in Phase 2. Technology validation and testing will be done in Phase 2.


**Keywords:** Fire suppression system for Li-Ion battery fires
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Digital method for imprOved Manufacturing of next-generation MultIfuNctIOnal airframe parts' (DOMMINIO).

assistant: **Concept**

DOMMINIO aims at developing an innovative data-driven methodology to design, manufacture, maintain and pre-certify multifunctional and intelligent airframe parts (composed of high-quality in-situ consolidated composite laminates and high-performance 3D-printed reinforcement elements) through a cost-effective, flexible and multi-stage manufacturing system based on the combination of robotized ATL and FFF technologies, supported by advanced simulation tools, on-line process & quality monitoring, SHM systems-enabled by embedded novel CNT-based fibre sensors and data analytics.Innovative multifunctional thermoplastic filaments will be employed to incorporate novel continuous CNT fibre-based piezoresistive strain sensors in the laminate, to enable reversible joining (using magnetic NPs) and increase the structural integrity (using continuous CF) of the 3D-printed reinforcements. Flexible automation of ATL and FFF manufacturing processes will be enabled by the development of new laser-scanning and smart nozzle systems, the simulation of ATL plies consolidation and interlaminar delamination in FFF and the development of novel air-coupled ultrasound quality monitoring systems. Besides, advanced modelling will support the selection of right process window parameters and the optimal production planning strategy, ensuring the quality of the final component. In addition, physics- and data-driven models (Digital Twin) will provide real-time data-driven fault detection capabilities supporting the implementation of new methodologies for SHM&M of multifunctional airframe parts.The DOMMINIO multi-stage manufacturing systems and digital pipeline will be tested and validated at lab-scale in two representative airframe parts (a multifunctional access door panel and a leading-edge wing prot