RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'APPLICATIONS of Fluorescent Microspheres with Long Emissive Lifetimes as Labels for Ultrasensitive Analytical Measurements' under Fourth Framework.

assistant: **Concept**

Fluoresczently labelled molecules are widely used in analytical measurements on account of the very high sensitivity which can be achieved in favourable circumstances. In particular, fluorescent labels are becoming important as replacements for radioisotopes in a variety of applications. The ultimate sensivity of such measurements depends on the ability to eliminate interferences from background fluorescence andscattered light. One very effective means to achieve this sensitivity is to use fluorescent lables with long emissive lifetimes, which can readily be distinguished from short-lived background emission. Recently developed technology has simplified lifetime-resolved fluorescence measurements to a level where these can be used routinely in analytical measurements. Unfortunately, many labels with long fluorescence lifetimes are particularly susceptible to fluorescence quenching by environmental influences. To avoid this we propose to develop a novel time-resolved fluorescence detection system designed for use with specially developed surface-engineered fluorescent labels of near-colloidal size. Such nanoparticles provide a protective matrix within which fluorescent species of long lifetime emit with very high efficiency. The proposed technology would expand the analytical applications of lifetime-resolved fluorescence detection. In addition, the nature of the measurement allows very low cost solid-state excitation and detection systems to be used in a compact format while maintaining very high sensitivity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Paraneoplastic Neurological Syndromes (PNS) clinical and laboratory aspects' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Paraneoplastic Neurological Syndromes (PNS) are rare diseases that can arise as remote effects of cancers. Since these syndromes are often the first sign of malignancy, correct diagnosis through the detection of specific autoantibodies could lead to early tumor discovery, when treatment could be successful. The infrequent PNS occurrence make it difficult to carry out extensive studies, a limitation, which can only be solved through international collaborative studies. The aim of this project is to develop a European partnership to produce a database, organize a sample bank for use by the participants in which sufficient, comparable data can be collected and finalized for clinico-laboratory studies. This would permit exploitation of data for scientific research, marking an important advance in neurological diagnosis and early cancer detection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Effects of extreme flow changes on periphyton biofilm and carbon cycling in Alpine streams' to be submitted under Horizon Europe.

assistant: **Abstract**

The year 2022 was a year of catastrophic extreme climatic events at an unprecedented scale. Rivers around the globe drying up, China's extreme heat wave, extreme floods in Pakistan and in the United States, are clear examples of a climate change scenario that is expected to be more and more pervasive in the next years.  Despite evidence of the increase in frequency and intensity of extreme events, the effects of the extreme oscillations between droughts and floods on streams carbon cycling are still uncertain. Alpine streams are important contributors of inland water carbon and changes that occur in alpine streams can profoundly alter downstream reaches affecting the global carbon budget and in turn exacerbate climate impact in the future. PeriCarb, EFA aims at understanding how periphyton biofilms community composition changes due to extreme flow change events and the reduction in the recovery time for the microbial community between events. It will link biofilm changes in community composition to changes in carbon cycling and in greenhouse emissions. By linking microbial ecology and carbon biogeochemistry changes in alpine streams PeriCarb will inform on the impact of climate change on global carbon budgets. PeriCarb will constitute a multidisciplinary project joining the applicant's previous experience with the excellence of the host institution and a group of established collaborators. It will provide advances for the field of carbon biogeochemistry and allow the applicant to return to Europe to establish as a researcher.


**Keywords:** Carbon cycling, GHG emissions, streams' metabolism, organic matter, limnology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'A critical evaluation of the dissolution mechanisms of high level nuclear waste glasses in conditions of relevance for geological disposal'.

assistant: **Concept**

Different theories have been proposed worldwide in the past years to interpret the considerable decrease with time of the dissolution rate of high-level waste glass upon contact with geological disposal media. These interpretations refer to saturation effects in the solution, to protecting effects of the reaction layer on top of the glass, or to ion exchange processes. The diverging interpretations hamper the efficiency of the R&D in this field and were recognized during an international workshop held in 2000. The objective of the proposal is mainly to achieve a common understanding on this interpretation. This will be achieved by applying a selection of existing analytical models on a limited amount of existing experimental data, both models and data referring to the differing interpretations, and by evaluating the output.Different theories have been proposed worldwide in the past years to interpret the considerable decrease with time of the dissolution rate of high-level waste glass upon contact with geological disposal media. These interpretations refer to saturation effects in the solution, to protecting effects of the reaction layer on top of the glass, or to ion exchange processes. The objectives of the proposal are to achieve a common understanding on this interpretation, and to quantify the uncertainty of the calculations done in models that are nowadays applied to the glass dissolution. This will be achieved by applying a selection of analytical models on a limited amount of experimental data, both models and data referring to the differing interpretations, and evaluating the output. The partners in this proposal involve laboratories that are dealing with these studies.The project will be split into the following actions (work-packages):(WP1) Formal overview of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The Effects of Precarious Work on Family Life in Europe'.

assistant: **Objectives**

This project investigates the effects of precarious work on family life in Europe. So far research on precarious work has mainly focused on effects on the labour market itself. However, with an increasing fragmentation of work histories, we have to expand our focus beyond the labour market and analyse the effects of non-traditional work forms on the lives of individuals and their families. Traditional assumptions about the separation of work life and private life are no longer feasible since working time and non-working time become increasingly interconnected in both a short-term and a long-term perspective. Being exposed to high labour market risks over the life course is likely to lead to changes in social behaviour and consequently to new social outcomes, which in turn require adjusted labour market policies. Exposure to risk may be especially consequential in critical life course periods which coincide with the need to make long-term commitments (such as in partnership and parenthood). This research project pins down the social effects of precarious work along two crucial dimensions of family life: (1) fertility and family formation and (2) family organisation and within-family time-use. It focuses on Germany, Italy, Poland, Sweden and the UK, representing five different welfare state regimes. From a methodological perspective, this research programme integrates economic and sociological research, also combining quantitative (i.e. microeconometric) and qualitative (i.e. case study) research. While micro-datasets and various national time-use data allow an analysis of fertility and within-family time-use, additional qualitative case studies in the above mentioned countries provide an in-depth analysis of the impact of precarious work on the life of families.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'MethylRIDE: Charting DNA methylation reprogramming of Ice Age horses in the face of global climate change and extinction' in the context of a Horizon 2020 call.

assistant: **Objectives**

MethylRIDE: Charting DNA methylation reprogramming of Ice Age horses in the face of global climate change and extinctionAdaptation is one of the most essential processes in biology, by which species become fit to their environment. Following Charles Darwin, adaptation appears as the result of natural selection acting upon heritable variation. However, recent epigenetic discoveries have established the capacity of non-genetic changes in the regulatory layers of gene expression to shape our traits, including our medical phenotype. As such, our realized phenotype can no longer be considered as the sole product of our genome, but more as the combinatory by-product of our genome and epigenomes. The outcome of natural selection, which favors phenotypes associated to a higher reproductive success in a given environment, might, thus, be at least partly influenced by epigenetic changes. Yet, the possible participation of epigenetic changes in the process of biological adaptation is generally overlooked. MethylRIDE will take advantage of the preservation of ancient DNA molecules in paleontological material to track the changes in DNA methylation profiles of Ice Age horses, as they faced changing climatic conditions and selection pressures and, ultimately, became extinct. The unique combination of novel experimental and computational techniques developed will help assess, for the first time, the role of epigenetics in long-term adaptive strategies of large vertebrates in response to rapid climate change, and more generally the role of epigenetic change as a significant evolutionary force.


**Keywords:** Ancient DNA,  adaptation,  horse evolution,  extinction,  climate change,  epigenetics,  environment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Translational control of mouse c-mos mrna'.

assistant: **Concept**

The c-mos proto-oncogene product is a key element in the cascade of events leading to meiotic maturation of vertebrate oocytes. The expression of c-mos mRNA during oocyte maturation is regulated at the translational level by cytoplasmic polyadenylation. Two U-rich cytoplasmic polyadenylation elements (CPEs) in the 3' untranslated region of mouse c-mos mRNA are required for this process. The goal of this project is to isolate the factor(s) that bind to the CPEs of mouse c-mos mRNA and to determine the mechanism by which they activate polyadenylation and translation. The CPE-binding factor (CPEB) will be isolated using several innovative approaches. Next, the binding of CPEB to c-mos mRNA and its role in polyadenylation will be analyzed. The RNA-binding domain and the effector domain of CPEB will be mapped. To investigate the mechanism of CPEB action, proteins interacting with its effector domain will be isolated using the yeast two-hybrid system. These proteins are expected to be involved in any of three processes: polyadenylation, translation or the regulation of meiosis, and are likely to establish links between these events.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Numerical and Experimental Investigation of Reinforced Concrete Structures Subjected to Impact Loads' (RCIMPACT) under Seventh Framework.

assistant: **Objectives**

The analysis and design of reinforced concrete structures against extreme loads, such as earthquakes, blasts, and impacts, has been an objective of many researchers and designers. As a result of recently elevated terror threat levels in the world, demand for the impact resistant design of buildings has increased. Numerous studies have been conducted to-date for understanding and developing methodologies predicting the behaviour of RC structures under impact loads. The proposed project aims to develop a nonlinear finite element analysis program for the analysis of reinforced concrete structures subjected to impact loads. The program to be developed will employ high-level state-of-the-art reinforced concrete modeling techniques. A well-instrumented experimental study will be conducted for corroboration, involving reinforced concrete slabs subjected to impact loads at the centre. Results of the experimental program will also be used for the critical evaluation of the current impact resistant design practices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Molecular spintronics using single-molecule magnets', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

A revolution in electronics is in view, with the contemporary evolution of two novel disciplines, spintronics and molecular electronics. A fundamental link between these two fields can be established using molecular magnetic materials and, in particular, single-molecule magnets, which combine the classic macroscale properties of a magnet with the quantum properties of a nanoscale entity. The resulting field, molecular spintronics aims at manipulating spins and charges in electronic devices containing one or more molecules. The main advantage is that the weak spin-orbit and hyperfine interactions in organic molecules suggest that spin-coherence may be preserved over time and distance much longer than in conventional metals or semiconductors. In addition, specific functions (e.g. switchability with light, electric field etc.) could be directly integrated into the molecule.  In this context, the project proposes to fabricate, characterize and study molecular devices (molecular spin-transistor, molecular spin-valve and spin filter, molecular double-dot devices, carbon nanotube nano-SQUIDs, etc.) in order to read and manipulate the spin states of the molecule and to perform basic quantum operations. MolNanoSpin is designed to play a role of pathfinder in this  still largely unexplored - field. The main target for the coming 5 years concerns fundamental science, but applications in quantum electronics are expected in the long run.  The visionary concept of MolNanoSpin is underpinned by worldwide research on molecular magnetism and supramolecular chemistry, the 10-year long experience in molecular magnetism of the PI, his membership in FP6  MAGMANet  NoE, and collaboration with outstanding scientists in the close environment of the team. During the last year, the recently foun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'DEVOPS-BASED SOFTWARE ENGINEERING FOR THE CLOUD' (DOSSIER-Cloud) under Horizon 2020.

assistant: **Objectives**

DOSSIER-Cloud implements a series of coordination and support actions for transferring knowledge and exchanging best practices in the research area of Software Engineering for Distributed Systems development. It brings together two internationally recognized scientific groups from Netherlands and Italy that collaborate with Cyprus University of Technology (CUT) so as to increase CUT’s research capacity and prowess, by investigating a number of significant topics in the field of interest. It is envisaged that a number of high-quality research outcomes will be defined during and produced after the duration of the project; this will enable CUT to significantly increase its international standing in the research community, by both achieving related publications in top-tier scientific journals and conferences, as well as by producing new tools that will benefit practitioners in the software industry. Knowledge acquisition and transfer is achieved through personnel exchanges, site visits, organization of workshops and summer/winter schools with lectures and seminars, participation in international scientific conferences/workshops and establishment of strong links with the software industry.The research topics include novel DevOps oriented software life-cycle methodologies for distributed systems, as well as automation of certain phases or activities. Emphasis is placed on industrial involvement and practitioners’ engagement. The anticipated overall impact of this project is: (i) Improvement of CUT’s research capacity, significance of research outcomes,productivity and visibility, (ii) Increase in developer productivity, reduction of development effort and improved quality of software services. The results are expected to:(i) dramatically impact the way distributed software se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dynamics of dense nanosuspensions: a pathway to novel functional materials' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Nanoparticles serve as additives for controlling the liquid properties. They areextensively applied in food industry and home care products, they are the essential part of ink and paint formulations and ofcoatings, they are used for manufacturing of functional materials and are very promising drug carriers. The presence of nanoparticlesin air or in water can influence the Earth ecology and human health. Although dilute suspensions of nanoparticles which are close toequilibrium have been extensively studied, in many important applications, such as food industry and printing, the suspensions aredense, or strongly interacting, they experience significant external stress and are far from equilibrium. A fundamental understandingof interaction between nanoparticles in liquid bulk and at interfaces, allowing to effectively use particulate systems in theseapplications, has not yet been achieved. The aim of the NanoPaInt network is understanding, predictive modelling and applicationof the strongly interacting nanoparticle-laden systems out of equilibrium. The specific objectives are: understanding stronginteractions between the nanoparticles and their effect on the rheological properties of suspensions; understanding the behavior ofnanoparticles in complex interfacial flows under strong external forces and with wetting and dewetting; design and applications ofsmart capillary nanosuspensions; drying of nanosuspensions towards assembly and fabrication of functional superparticulatesystems. The training aim of NanoPaInt network is to support the career development of young researchers both in academic andnon-academic sectors and to train a new generation of creative, mobile, entrepreneurial and innovative early-stage researchers(ESRs) through the experience of independent and inter