RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Defining the functions of Elongator in adult brain neurogenesis' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The olfactory bulb (OB) is one of the few structures in the adult forebrain in which there is a continuous supply of newborn neurons. Neuronal precursors are generated in the subventricular zone (SVZ) and follow an intricate migration path before reaching their final position in the OB.Familial dysautonomia is a neurodegenerative disorder that result from the impairment of Elongator activity. Elongator is a six unit complex assembled by its scaffold protein Elp1. The host laboratory has recently shown that the catalytic activity of this complex underlies radial migration and branching of cortical projection neurons by promoting the acetylation of α-tubulin.In the adult brain, the stem/neural progenitor express Elongator subunits and Elp1 level expression increases dramatically after treatment that promotes neurogenesis. The overall goal of the current project is to understand the functions of Elongator in adult brain neurogenesis.I propose:- To analyze the expression pattern of Elongator in adult SVZ.- To dissect the role of Elongator on neuroblasts migration within the rostral migratory stream (rostral migration) and the OB (radial migration).- To define the role of Elongator on interneuron differentiation in the OB.- To characterize new cytoplasmic targets of Elongator that promote adult neurogenesis.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Alimentary machine safe welding by yag laser technology' (1998-2002).

assistant: **Concept**

The project novelty is in the application of laser welding to the production of machines for the alimentary sector and in the characterisation of weld toxicity and weld performance by testing and analysis. The application of laser welding technology to the production of alimentary machines is not a simple case of technology transfer, because the capability of laser welding requires further specification with respect to the definition of optimal process parameters (welding speed, laser power, protective environment) for different materials and applications. In fact the deformations occurring on the welding often induce local damage and subsequent loss of material and, as a consequence, toxicity. The present proposal constitutes a good step towards the adequacy of the SMEs production to the European normative especially from an environmental point of view (Council Regulation (EEC) No 315/93 of 8 February 1993).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Personal Transport Advisor: an integrated platform of mobility patterns for Smart Cities to enable demand-adaptive transportation systems' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The aim of this proposal is to develop a service platform that connects the providers and controllers of transport in cities with the travellers in a way that information flows are optimized while respecting and supporting the individual freedom safety and security of the traveller. Cities will get an integrated platform to enable the provision of citizen-centric, demand-adaptive city-wide transportation services. Travellers will get mobile applications that facilitate them in making travel priorities and choices for route and modality. The work will result in a city-wide transportation system comprised of several sub-systems that involve transportation services and policies to be adaptive to the travel demand of the citizens. To achieve this, the platform will fuse different data from various city sources, travel operators and citizens, perform a broad class of predictive analytics, detect the real-time events based on the analytical information and real-time data, and provide information services to the transportation service providers and city stakeholders to optimize the transportation offerings according to the citizens' interests. The envisioned platform will address key research challenges by (a) enabling a coherent model of mobility patterns via the capture of their multi-dimensional, collective, analytical and dynamic aspects, (b) driving the application of this model via incorporation into various transportation services and city-level policy evaluations. The project will pay specific attention to the governance aspects on how to handle the public – private and privacy issues of connecting travellers, cities and transport providers together through such a platform. Three cities with very different use cases will implement and evaluate the platform and will hos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'THE USE OF INTERNATIONAL TAX ARRANGEMENTS TO PROMOTE GLOBAL WEALTH REDISTRIBUTION'.

assistant: **Innovation**

The proposed research seeks to determine how international tax arrangements could advance global wealth redistribution in a world of enhanced economic integration. Globalisation has placed traditional income tax systems under siege as domestic tax regimes fail to coordinate their actions to effectively tax cross border transactions. Furthermore, even though global markets operate in a world characterized by tremendous poverty and inequality, the international taxation literature rarely directly addresses issues of global distributive justice. If taxation is the price for civilization, then the burden of addressing issues of international taxation is the price for globalisation. The proposed research would stress that while international taxation may indeed be a cost of globalization, it is also a potentially powerful instrument to promote more just global market arrangements. To demonstrate this point, the proposal advances two related strands of research. The first strand would determine how international tax arrangements should be structured to take distributive considerations into account. Taxes involve big money, and therefore allocating the right-to-tax among nations has a distributional impact that should be addressed. This component of the proposal aims to establish the notion that international tax arrangements can promote global wealth redistribution more effectively than other tools such as trade regulation. The second research strand would demonstrate that a fair tax regime, which considers issues of redistribution, would also allow for stable multinational tax coordination. Including a fair redistributive component into such a tax-coordination arrangement would provide it with political legitimacy and incentivise developing countries to join it. The proposed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Life extension of alumina forming alloys in HT corrosion environment'.

assistant: **Concept**

This Focused Fundamental Research Programme is aimed at improving the chemical failure resistance of alumina scales which are essential for the corrosion protection of current and future MeCrAIRE alloys (where Me = Fe, Ni, Co and RE = reactive element) for high temperature industrial applications, such as automotive catalytic converter supports, furnace components, power generation, plant structural components, etc. The crucial importance of chemical failure in ultimately goveming the lifetime of such components under service conditions has been identified, and emanated from a recently completed Brite/Euram Project BRE-CT94-0605 whose principal goals were the mechanistic understanding/modelling of the mechanical failure of these scales. The present programme is a logical extension of this work. Its industrial and technical objectives are to: I) understand the mechanisms of the chemical failure of alumina forming alloys leading to breakaway corrosion; particularly the role of minor alloying additions impurities within commercial alloys and the role of more complex industrially relevant (e.g. combustion) environments, as well as oxidising conditions. 2) develop mathematical models capable of predicting the onset of chemical failure and thus the durability of high temperature alumina forming alloys for a range of industrial service environments and conditions. 3) recommend modifications toy compositions, pretreatments and plant operating procedures for extended life. These objectives will be achieved by a two phase technical programme. Phase I will address chemical failure under oxidising conditions and involve five tasks (critical analysis of available information; materials selection; definition of test methodologies; data generation/mechanistic understanding; life time
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The NeoKidney: Next Generation Hemodialysis Device Making Hemodialysis Finally Portable' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

NextKidney BV, founded in 2014 and based in Netherlands, is revolutionizing kidney care with NeoKidney, a compact, truly portable home hemodialysis (HHD) device. With over 5 million end-stage renal disease (ESRD) patients worldwide, most rely on costly, in-clinic dialysis, which limits mobility, increases fatigue, and has sub-optimal health outcomes. HHD offers benefits over in-clinic dialysis, but adoption remains below 2% due to current devices being bulky and challenging to set up. NeoKidney addresses these barriers by offering a 10 kg portable device that uses patented sorbent technology to recycle dialysate, reducing fluid needs from 45 to 5 liters per session. Its innovative cardiac floating technology also eliminates the need for electrical grounding, enabling use in various settings, including remote and disaster zones. Together, these features make NeoKidney more easily accessible to patients.NeoKidney’s benefits include 40% reduction in mortality, greater patient independence, and healthcare cost savings of up to 43% per patient annually (from €92K to €53K). Integrated remote monitoring allows healthcare providers to track patient data in real time, reducing need for hospital visits.  With global dialysis market valued at €82 billion in 2022, and HHD segment expected to grow to €7 billion by 2035, NeoKidney aims to capture significant market share, with projected sales of €650M annually by 2035. NextKidney's commercialization strategy includes selling both the NeoKidney device and high-margin consumables, with initial market entry in Europe and the U.S.  NextKidney seeks €41.5M in funding, including €2.5M in EIC grants and €39M in equity (€15M from EICA and €24M from current and additional investors), to accelerate clinical trials, regulatory approval, and mar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Heritage conservation and management in egypt and syria' (HERCOMANES) under Fifth Framework.

assistant: **Objectives**

The fundamental goal of this research project is the upgrading of management systems able to restore and conserve historic sites, monuments and objects. It will seek to supply the inputs of knowledge required to optimise intervention and assist in decision-making. The research focuses on the late nineteenth and early twentieth century city centres of Cairo and Aleppo. It breaks new ground in the nature of subject mater and goes hand in hand with a conservation process that has recently embarked in both cities. It will contribute to the definition of an appropriate inventory method of valuable objects, in addition to an analysis approach homing in on three levels: the area the street and the edifice; with analysis fine-tuned to building materials and techniques, and assess the economic feasibility.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'AI and Robotics for Prostate Biopsy', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The ROBIOPSY project aims at evolving the robotic device for prostate cancer (PC) biopsy demonstrated during the ERC-PoC PROST into a product prototype that will be ready for clinical trials. The focus of the project will be two-fold: the engineerization of the PROST prototype, and the accurate analysis of the business case of prostate cancer diagnosis and its potential extension to focal therapy. We will correct the shortcomings of the pre-clinical tests, meet the strict medical certification regulations, and address the Health Economics implications of our solution. ROBIOPSY will achieve better performance than current competitors because it solves the two main causes of PC diagnostic error: uncertain target identification, and inaccurate needle positioning, as demonstrated in the pre-clinical tests. A novel image fusion method will permit to significantly reduce the target uncertainty, while the robotic device will zero the positioning error.The ROBIOPSY prototype will consist of a single cart holding the robotic needle positioner, and housing all the electronic components. The electronics will be divided into two subsystems: interface and data processing, and safety critical controls. This will reduce the operational risks and will simplify the medical certification. A multi-centric study is ongoing to collect biopsy images to train the Machine Learning algorithms for prostate segmentation and lesion identification. In parallel to the technical development, we will analyze in depth the business case of prostate biopsy in selected European Countries, we will analyze the time/cost reduction due to the new device and will establish the economic foundation of focal therapy, to be ready for the expected evolution of PC treatments.


**Keywords:** Robotics for healthcare,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Unified Enterprise Modelling Language' (UEML), addressing dissemination and exploitation.

assistant: **Impact**

The objectives of UEML Working group is to define, to validate and to disseminate a set of core language constructs to support a Unified Language for Enterprise Modelling, named UEML, to serve as a basis for interoperability within a smart organisation or a network of enterprises. After a state of the art, the working group will detect the user requirements in terms of Enterprise Modelling application domains, methodology and software tools. The foundations of the UEML will be defined and the future development topics established. A demonstrator portal will be developed to inform potential interested users on the language development and to gather their recommendations. The UEML working group results will be also disseminate through papers, demonstrations, workshops. The project aims at the end, to prepare a complete project to develop the complete UEML.OBJECTIVESThe objective of the UEML project is to create an UEML Working group which aims: - at creating a European Consensus on a common Enterprise Modelling Language and to facilitate interoperability in the frame of on-going standardisation efforts in this domain. The common language representing this consensus will be defined in terms of a core set of modelling constructs - at building an UEML demonstrator to promote, test, and collect comments on the proposed Modelling Language Constructs- at preparing the launching of project to define, implement, extend, the complete UEML. The UEML working group will be composed of a core membership of 8 partners and of an UEML network of persons interested by the development of such a language.DESCRIPTION OF WORKThe structure of the project is organised in six work-packages:WP1: "State of the art" will define a framework for characterizing current EM approaches, use this framewor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Regional aspects of the sustainable management of wetland resources' under Fifth Framework.

assistant: **Concept**

The accompanying measure is directed at increasing the regional dissemination and application of the tools developed in a precedent INCO project (IC18 CT98 0262). The measure is specifically designed to involve the decision makers and scientists who will use the instruments focusing on the management of wetland resources in a wider regional approach. The participation of all levels of actors, research institutions and government bodies will guarantee a high profile of the measure results and a good dissemination of the activities. By creating a regional dialogue, wetland management will be improved over a larger area, increasing the value of the results from the original INCO project. The measure also involves a feasibility study to determine where further research should be dedicated as well as the actual application of instruments from the original INCO project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'CONSORTIUM FOR DEVELOPING REGULATORY CAPACITY FOR CLINICAL TRIALS USING GENE THERAPY PRODUCTS AND STRENGTHENING PHARMACOVIGILANCE IN THE CONDUCT OF CLINICAL TRIALS IN EAST AFRICA' (2021-2027) under Horizon Europe.

assistant: **Objectives**

Gene therapy advancements have shown promise in treating chronic conditions like HIV and Sickle cell Anaemia and have the potential to greatly reduce the burden of disease in Sub-Saharan Africa which is plagued with a double burden of communicable and non-communicable diseases.  These treatments have the potential to reduce the burden of disease for the populations for which they are targeted and the cost of treatments for governments. In Sub-Saharan Africa, there are largely no or unclear regulatory frameworks for clinical trials using Gene Therapy products. As pioneers setting up frameworks for regulatory oversight of clinical trials using Gene and cell-based therapy products, Uganda and Tanzania will be able to share this knowledge through regional platforms to support other countries in the region to put in place similar regulatory frameworks. Additionally researcher workshops and course developed on Gene Therapy Products will build capacity among researcher, regulators and the public.Pharmacovigilance in clinical trials for safety of trial participants and to accurately characterize the safety profile of the drug for the targeted patient population. Safety monitoring in clinical trials in the region, currently faces challenges associated with health system challenges, investigator awareness, poverty and limited access to diagnostic tools. Additionally, there is limited investigator awareness of  of their responsibility to the patients with regard to monitoring and treating and accurate reporting of serious adverse events during clinical trials.  The results of this project will also provide a basis to sensitize investigators/sponsors and engage policymakers on the requisite health systems reforms to create a safe environment for the conduct of clinical trials with