RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Flood fOREcasting with Satellite Imagery and Generative High-resolution Techniques' (FORESIGHT) under Horizon Europe.

assistant: **Objectives**

Floods are among the most devastating natural disasters, causing widespread destruction and economic losses globally. Despite advancements in flood early warning systems, they remain limited in their ability to mitigate such losses, primarily due to a lack of accurate real-time flood inundation maps (FIMs) forecasting and reliable uncertainty quantification. The overall goal of the FORESIGHT project is to develop a framework to address this critical gap by leveraging cutting-edge Generative Artificial Intelligence (GenAI) techniques to forecast real-time FIMs with high resolution (30 meter/6hr) up to 5 days ahead. The proposed approach offers multiple advantages: it enables fast generation of FIMs by employing GenAI and omitting the time-consuming physical hydraulic model component of traditional approaches. It ensures accuracy by modifying dynamic river networks and improving precipitation forecast uncertainties. Physical consistency is maintained by training GenAI with data output from physical models. Crucially, it provides reliable uncertainty quantification for the generated forecasts. This innovative approach will be applied across four diverse large river basins - the Rhine, Indus, Niger, and Severn - to ensure broad applicability. Additionally, I will test the approach in ungauged basins to assess its potential applicability in data-scarce regions. By utilizing only satellite earth observation data and open-source global coverage data, the project aims to pave the way for the development of global operational flood forecasting systems.


**Keywords:** Flood inundation, Generative AI, Hydrological model, Hydraulic model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'European Clinical Research Infrastructures Network - Integrating Activity'.

assistant: **Objectives**

ECRIN is a distributed ESFRI-roadmap pan-European infrastructure designed to support multinational clinical research, making Europe a single area for clinical studies, taking advantage of its population size to access patients. Servicing multinational trials started during its preparatory phase, and it now applies for an ERIC status by 2011. The ERIC budget will be restricted to core activities required to enable provision of services, and the ECRIN-IA project is designed to expand ECRIN partnerships and impact beyond this core activity.Networking activities will promote pan-European expansion, capacity building, and partnership with other world regions, and address the funding issue (WP2). ECRIN-IA will develop e-services, education material to train professionals and patients associations, and communication with users, patients, citizens and policymakers (WP3). It will support the structuring and connection to ECRIN of disease-, technology-, or product-oriented investigation networks and hubs focusing on specific areas: rare diseases (WP4), medical device (WP5), nutrition (WP6).Transnational access activities will support the cost of multinational extension of clinical trials on rare diseases, medical device and nutrition selected by the ECRIN scientific board (WP7).Joint research activities are designed to improve the efficiency of ECRIN services, through the development of tools for risk-adapted monitoring (WP8), and the upgrade of the VISTA data management tool (WP9).This project will build a consistent organisation for clinical research in Europe, with ECRIN developing generic tools and providing generic services to multinational studies, and supporting the construction of pan-European disease-oriented networks, that will in turn act as ECRIN users and provide the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Numerical fuel cell component performance prediction (NFCCPP)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Objectives:Fuel cell systems are highly complex power systems consisting of different sub-systems and a multiplicity of components. These components interact closely together and influence each other and the whole system. To develop and optimise a single component it is necessary to control the influence of modifications and improvements on the total system. The purpose of the Fuel Cell Component Performance Prediction Tool is to aid suppliers in the development of components for fuel cell systems by providing a numerical simulation tool capable of evaluating and optimising their products in a fuel cell system. The tool is also expected to help suppliers to demonstrate the potential of their components in a virtual fuel cell application.Description of the work:In the first year of the actual project, standard interfaces and I/O data characteristics have been identified for all relevant components of current as well as future fuel cell systems. Requirements of latter systems were taken into consideration by in-depth technology monitoring of all partners involved. Thus, expert know-how for each important component and subsystem has been concentrated, which allows a unique parallel strategy for the sub model development started already: on the one hand, all components from the fuel tank to the system controller are modelled individually - on the other hand, the partners responsible for the model generation can contribute their dedicated expertise as being one of the leading companies in the related technology field. Moreover, the concept for the simulation toolkit has been defined such that a later extension with confidential, encrypted models will be possible. This unique approach should lead to a future simulation platform where software-in-the-loop (SIL) and hardware-in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Structural and functional studies on Plasmodium formins' (FORMIN), addressing dissemination and exploitation.

assistant: **Impact**

Funding is applied to carry out research on formin-mediated regulation and dynamics of actin-based motility of apicomplexan parasites, such as Plasmodium, the causative agent of malaria. Formins are large multi-domain proteins, which regulate microfilament formation by triggering actin monomer addition from actin-profilin complexes at the barbed end. Formins bear two formin homology (FH) domains. Plasmodium FH2 domains are conserved with higher eukaryotes and are responsible for actin binding, while Plasmodium formins contain only putative short FH1 domains with a small number of prolines that could be recognized by proline-rich motif binding proteins, such as profilin. The aim of this study is to find out if these short proline-rich regions in apicomplexan formins are enough for recruiting profilin–actin complexes and to perform structural and biochemical/biophysical characterization of the formins and their binding partners. In addition, crystal and solution structures of the ternary complex actin-profilin-formin will be pursued. These data are expected to provide us with a structural basis for understanding the mechanism of actin-based motility in apicomplexan parasites. The host laboratory has excellent facilities for molecular biology, protein production as well as X-ray crystallography. I myself as the applicant have spacious knowledge in these methods. The planned visit will be the first post-doctoral period for me and will serve as an important step to develop my scientific career.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Neuro-metabolic, structural and functional hallmarks of Lysosomal Storage Diseases' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Continuing development of novel brain treatments, which bypass blood-brain barrier, further emerges the need to establish prognostic magnetic resonance (MR) markers to track progressive brain alteration in lysosomal storage diseases (LSD). Excessive intracellular accumulation of lysosomal substances such as glycosaminoglycans in mucopolysaccharidosis (MPS), globotriaosylceramide in Fabry disease and glycocerebroside in Gaucher disease (GD) triggers multi-organ malfunctioning and significant damage to the central nervous system. While LSD are associated with various levels of cognitive deficits, and distinct extents of morphological brain abnormalities (e.g., atrophy, leukodystrophy or enlarged perivascular spaces) ranging from non-existing in GD type 1 to severe in MPS type 2, microstructural and metabolic processes have not been comprehensively described in brains of LSD patients in vivo yet. We will utilize cutting-edge accelerated proton MR spectroscopic imaging methodology that was developed at the Medical University of Vienna in combination with advanced diffusion MRI, high-resolution T1-/T2-weighted ratio, and pseudo-continuous arterial spin labeling technique. Our protocol will reliably quantify levels of all relevant brain metabolites, while sensitively describe microstructural and functional deficits to determine the relevance of MR measures in psychological deficits in LSD. Reproducible MR methods are needed to assess effects of novel treatments that overcome blood-brain barrier such as intrathecal enzyme administration, chaperones and gene therapies in clinical LSD trials. Increased understanding of brain LSD pathology will critically boost search of optimal therapies in age-related neurodegenerative diseases that share some common features with LSD such as A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Identification and characterization of molecular markers of pancreatic Endocrine Progenitor Cells' (2007-2013).

assistant: **Innovation**

Embryonic stem (ES) cells are derived from the inner cell mass (ICM) of blastocyst-embryo stage. The potential of ES cells to differentiate in all kind of tissues, opens the possibility for future promising approaches, as genetic therapy and/or cell replacement, to treat many diseases, including type1 diabetes. Although several scientific groups have reported the successful differentiation of mouse ES cells to insulin producing cells, the therapeutic benefits have yet to be achieved. Recently, in convincing experiments, it has been suggested for the first time that the adult pancreas contains “Endocrine Progenitor Cells (EPC)”  that differentiate in beta cells. The lack of “signature genes” is a main limitations to isolate and to culture pure populations of EPCs. Our study aims to find new molecular markers specific of beta cells progenitor cells. To systematically identify gene candidates as markers expressed in EPC, we will screen the enormous source of expression data from cDNA library and microarray public databases (like MIAMI, NCBI) of mouse ES cells differentiation toward insulin producing cells and definitive endoderm derivatives. The evaluation of such genes will prominently performed in vivo using various techniques (like in situ hybridization, immunostaining). To study the specification of EPCs and characterize  in vitro plasticity, we aim to generate stable modified (knocked-in)  mES cell lines reporting expression of new identified EPCs specific marker through GFP (green fluorescent protein).  We aim to isolate EPCs homogeneous population both in vivo and in vitro by Fluorescence-Activated Cell Sorting (FACS) and Laser Capture microdissection (LCM). RNA obtained from such cells will be amplified and hybridized to Affymetrix mouse gene chip MOE430_2 to condu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Thermal Characterization of Advanced Material in Ultra-scaled Microelectronic Devices' (TCAMMD).

assistant: **Concept**

The constant improvement of microelectronic devices is based on their miniaturization from the micrometer to the nanometre scale. This continuous scaling down calls for new materials and new device concepts. At the nano-scale, the thermo-physical properties of the materials have a fundamental impact on the electronic behaviour of the device. Despite this, a non- destructive experimental technique capable of determining the thermophysical properties of the key materials in a real microelectronic device is still lacking. The goal of this project is to develop a technique, based on the infrared radiation measurement, capable of addressing the device nano-scale. To achieve this objective the experimental technique must be combined with the heat transfer modelling in the device under investigation.The project will focus on specific microelectronic devices such as ultra-scaled metal-oxide-semiconductor field-effect transistors (MOSFETs) as well as novel non-volatile memories (NVM) based on phase-change materials (PC M). In the latter case the determination of the thermal properties of the active material (calchogenides) and of the heater (TiN) is very important for the device functional characterization. An additional objective of the project is also to use the developed technique to address the thermo-physical properties of thin films, such as oxides with high and low dielectric constant, which today are considered as substitutes of silicon oxide both in the front as well as in the back end of near future CMOS technology.This study will be carried out in collaboration with an important European industrial partner, STMicroelectronics. This work will therefore contribute to a relevant technological evolution in the field of microelectronics with consequent economical repercuss
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European youth in education and in transition to the labour market' (EDU-LAB) under Horizon Europe.

assistant: **Objectives**

The EDU-LAB is a comparative European study that systematically examines factors and determinants influencing choices, pathways, and transitions in education and training (E&T) and from E&T to the labour market of young people aged 15-30 years. The focus is on equity and inclusion, and on young people’s participation, progression, and completion of upper secondary and tertiary general education (GE) and professional/vocational education (PVET, at ISCED levels 3-8), as well as on their transitions to and from the labour market. First, EDU-LAB will develop comprehensive models of pathways and transitions per country in the European Education Area (EEA) including their intersectional and largely generic determinants. Second, an efficiency assessment of policies and investments in GE and PVET will be carried out. Third, novel quantitative and qualitative evidence will be provided on how determinants, including policies and investments, contribute to young people’s pathways and transitions, specifically to inclusion and equity, and their participation and completion of GE and PVET. EDU-LAB relies on a mixed-methods approach, with emphasis being placed on secondary quantitative analyses of openly available empirical data and newly collected qualitative empirical data. Specifically, EDU-LAB considers all stakeholders and conducts a systematic literature review, qualitative conceptual analysis, quantitative trend and regression analysis, difference-in-differences analysis, expert interviews and surveys, and qualitative case studies focusing on young people’s voices and based on Research-Practice Partnerships. The following EEA targets are scrutinized: (a) increasing the rate of youth with tertiary education attainment; (b) reducing the share of early leavers from E&T; (c) incre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Enzymatic synthesis of organic molecules in alternative solvents'.

assistant: **Innovation**

The growing awareness of the pressing need for greener, more sustainable technologies has focused attention on the use of atom efficient catalytic methodologies for the manufacture of fine chemicals and pharmaceuticals. The use of alternative reaction solvents such as supercritical fluids or fluorous biphasic systems that are readily recycled has therefore become the focus of significant research that could circumvent the problems associated with many of the traditional volatile organic solvents. Thus novel and effective methods for reactor design, enzyme recovery and recycling are receiving increasing attention. New approaches to tackling these issues form the main objectives of this Proposal. The use of immobilized enzymes in the form of Cross-Linked Enzyme Aggregates (CLEAs) in supercritical carbon dioxide (scCO2) or fluorous reaction media including the use of ‘combi-CLEAs’, two enzymes that catalyse complementary reactions for one-pot two-step conversions in both batch and continuous reactions forms one major task. The use of hydrophobic-ion pairing of enzymes with perfluorinated surfactants to solubilise them in scCO2 and fluorous solvents and thus allow homogeneous catalysis to occur is the focus of the second task. The oxidases catalyzing the mild and clean formation of H2O2 from dioxygen will be investigated. This H2O2 will then be used in epoxidation and Baeyer-Villiger chemistry, either on the product of the oxidase reaction or a second substrate. Enzyme catalyzed polymerization reactions in scCO2 and fluorous solvents will also be investigated including the formation of perfluorinated polymers that may have unique physical and chemical properties. This fellowship will bring together strong research background of Dr. I. Lapenaite with excellent training oppor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Controlled Closed Loop Recycling for Life-Cycle Optimised Industrial Production' (CONCLORE).

assistant: **Concept**

Currently, existing polymer closed loops in the automotive sector achieve targeted ratios but in next future it will become more complicated due to reducing the overall vehicle weight by increased use of polymer. ELV components with an economic value are r ecovered and reused on an ad-hoc basis without central direction or regulation. The majority of ferrous and other metals remaining within the ELV are shredded and recycled in different industries. The residual material, up to 30% of the weight of the vehic le, is termed Auto Shredder Residue (ASR). ASR consists of plastics, rubbers, foams, glass, etc. ASR is usually incinerated or disposed on landfills, since the multi-material nature of ASR makes it economically impossible to segregate, recycle and reuse it . CONCLORE will develop a sustainable, low emission system to manufacture a 100%-recyclable single-component car interior product; the material will be recovered at the end of the useful life of the vehicle and will recycled back into another product eith er for consumption within the automotive industry or for another end use outside of this market. The development will be carried out exemplary for a representative engine compartment part. To enhance the currently achieved recycling ratio it is mandatory n ot only to change single stages within the production system of automotive part. It is rather necessary to develop a new concept which enables the reintegration of recycled polymer material with a continuous quality. The concept of Controlled Closed LOop R Ecycling (CONCLORE) connecting primary forward supply chain management with reverse supply chain management. The controlled closed loop recycling will provide the increase of using recycled materials in sophisticated applications by an economical viable so lu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on '300 mm Silicon Service Centre'.

assistant: **Innovation**

The European semiconductor equipment industry - mostly SMEs - is facing the transition to 300 mm processing, which has been delayed worldwide and is only now really starting. The objective of the project is to offer a structure to the equipment suppliers that provides low cost 300 mm silicon wafer services for Proof of Concept Tests under SEA mainly at supplier sites (similar to wafer, analytical and metrology support offered in SEA 300 under Esprit). As there is no single site existing to provide such support, 300SiSC will co-ordinate such services from wherever they can be received at the required quality and at competitive costs. Taking advantage of their experience in 300 mm processing, 300SiSC will co-ordinate its work with dissemination activities for assessment take-up measures under IST in FP5 (project IST-11025, SEAD).