RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Easy and friendly access to geographic information for mobile users' to be submitted under Fifth Framework.

assistant: **Abstract**

HYPERGEO aims at providing technical tools to enable value-added information services related to Geographic information. HYPERGEO name shows that the project handles both information (HYPER or Hypertext) and geography (GEO). The technical objectives are to develop and integrate, in single system, innovative software components enabling the users to formulate advance requests, to access information in both pull and push modes, and to display the information in efficient multi-layered" form.The business objective is to prepare the way for innovative services offerings for primarily for mobile needing to access geographic information for their activity. Mobile users are the main, but not exclusive, target. It will also be applied to fixed users, being interested in geographic information. Detailed objectives are:Study and develop advanced information technology components to improve information systems efficiency and user friendliness.Study new methods to make efficient use of remote geographic information, in particular for mobile users.Demonstrate the performances through a Tourism Information system because its requirements are very representative.Show possible extension to other information systems applications and define possible models for operation.Work description:HYPERGEO workplan includes the following activities:Research and development activities:Research and development activities for human centred information technology in following areas:- Distributed information access and management (data mining)- Advanced request tool, including natural language processing.- User profile and preferences, including geographic location.- Improved Information presentation (with geographic attributes) and access (security/privacy).Four components, covering the above issues, w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'PYROlysis based process to convert small WWTP sewage sludge into useful bioCHAR'.

assistant: **Objectives**

The PYROCHAR project brings together five SMEs and three research institutions to address the increasingly pressing issue of sewage sludge disposal in Europe. PYROCHAR will provide small municipalities and their waste water treatment plants (WWTPs) with an economically and environmentally sound solution for the treatment and disposal of their sewage sludge.The implementation of European Directives for waste water treatment, while improving general quality and management of wastewater in the Union, has led to a situation in which, today, 10 million tonnes of sewage sludge are produced annually across the 26 member states.More than 60% of the WWTPs in Europe service small municipalities. For these plants, the established sludge treatment and disposal options, developed specifically for large treatment plants, are too complex and expensive to provide on-site practical solutions.Because of this, small WWTPs face a number of challenges presented by sewage sludge:•  They must comply with EU directives for wastewater treatment and sludge management.•  The costs of sludge treatment, storage and transport to composting/incineration facilities, farming or to larger WWTPs for further treatment are high.•  New technological solutions and those in development are focused on medium to large scale WWTPs. The adaptation of these to small scale plants requires investment and investigation that are simply not prioritised.•  There is a high level of public mistrust of sewage sludge and its reuse, which widespread fears about adverse effects on the environment and human health.The PYROCHAR technology will thermochemically treat sewage sludge, converting it to biochar (biomass-derived charcoal) and synthesis gas (syngas) in a system with low operation and maintenance costs and compliant wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Prime editing to Repair Inherited Metabolic Errors:  in vivo gene correction for human genetic disease'.

assistant: **Innovation**

Treatment options are insufficient for the majority of genetic metabolic diseases. Methylmalonic acidemia (MMA) is one such severe metabolic disease. With current therapeutic strategies, patients still develop metabolic decompensations, brain damage, kidney failure, and have a lifelong risk to acutely become blind. Repair of the genetic cause of disease would revolutionize outcomes for these patients, especially with increasing detection in neonatal screening programs. This makes it possible to correct the cause of disease prior to the onset of irreversible damage. However, efficiency, safety, versatility and delivery of precise gene editing is not yet sufficient for in vivo gene-correction therapies.The aim of this proposal is to develop an in vivo gene-editing therapy program for patients with metabolic diseases targeting the liver, where most metabolic genes are highly expressed. As a proof-of-principle, I will repair genetic causes of MMA, validate this in personalized cells and mouse models, and lay the groundwork for human trials.To this end, I will:(1) Generate a clinically applicable gene-editing technique. I recently demonstrated that the novel gene-editing technique prime editing could accurately correct different mutations in patient-derived organoids. Using an innovative reporter and patient-derived organoids, I will develop prime editing into an efficient and safe strategy that can correct >90% of patient mutations.(2) Create a system for in vivo delivery of the prime-editing machinery with lipid nanoparticles to target the liver, using patient-derived liver organoids and an existing MMA mouse model. (3) Develop a roadmap to tailor gene-correction therapies to individual patients, using the reporter with the patient mutation and mutational context, patient-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Notch and epithelial proliferation' (PRONO) targeting Seventh Framework.

assistant: **Abstract**

During development the different organs and tissues of an organism have to grow harmoniously to reach their specific shapes and sizes. In the adult, organs have usually reached an equilibrium, where loss of cells must be compensated by tightly regulated proliferation. During cancer, groups of cells evade these controls and start to proliferate abnormally.The Notch intercellular signalling pathway is very conserved throughout evolution and directs a wide variety of cell fate decisions and behaviours. The specificity of outcome relies on the implementation of different transcriptional programmes. For instance, in certain epithelia from very diverse animals, Notch controls epithelial cell proliferation and tissue growth. In order to identify the genes mediating this effect of Notch, using genomic approaches, I have identified the direct Notch targets during wing discs hyperplasia in Drosophila. Functional analysis revealed complex cross regulation between targets and feed forward logic loops. What are the important functional nodes of the network of genes activated by Notch, and how does it operate?The current proposal seeks to reach an unprecedented detailed description of the Notch network mediating epithelial proliferation in Drosophila both during hyperplastic and neoplastic growth. More specifically, and using a combination of genome-wide approaches and elegant functional validation through Drosophila genetics, my aims are:- describe the global microRNAs response to Notch in hyperplastic Drosophila wing discs and understand how it shapes the Notch network during hyperplasia;- understand how this network is reshaped during the transition from hyperplastic to neoplastic growth, and identify a neoplastic specific programme;Critical aspects of the Notch network governing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Improved healthcare for patients with primary antibody deficiencies through new strategies elucidating their pathophysiology (IMPAD)'.

assistant: **Concept**

Primary antibody deficiencies like common variable immunodeficiency, IgA-deficiency and the non-X-linked hyper-IgM syndrome are rare, chronic diseases that are severely complicated by recurrent bacterial infections, poorly recognized in daily medical practice and expensive to treat. To understand their unknown etiologies, our multidisciplinary approach combines 10 European groups to identify the genetic origins of the deficiencies, the genetic risk factors in different European populations, the defects and changes in inter- and intracellular signalling pathways and their pathophysiological relations to immunological phenotypes and function.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Fostering  Internet-based  Values of the  Environment'.

assistant: **Objectives**

Nature-experiences are on the decline, but does that mean environmental values are as well? — Where the decrease of experiences of nature is often cited as a cause for dwindling appreciation of nature and consequently less commitment to environmental stewardship, I argue that the internet is an overlooked factor in multiplying nature experiences, creating nature values, and fostering environmental stewardship, thus counteracting the ‘extinction of experiences’ of nature. With more than half of the global population already using social media, the BIG-5 project utilizes five of the world’s largest social media platforms to better understand the fostering of physical-virtual nature interactions that support sustainable global transitions in a rapidly changing world. The BIG-5 project introduces Digital Relational Values (DRVs) as fundamental and eudemonic values that are developed within virtual communities, triggered by indirect experiences of nature. It will trace these values across five landscape types, five large social media networks, and in five European languages through qualitative and quantitative (big data) approaches in an inductive-deductive manner. Furthermore, the BIG-5 project will develop and apply innovative empirical approaches that allow to (a) identify DRVs across different social media platforms, (b) understand how they spread across virtual communities, and (c) examine the relationship between virtually produced DRVs and physical environmental stewardship. BIG-5 will thereby challenge the assumption of an “extinction of experiences” and the consecutive decline of nature values and care for the environmental. It will further strengthen the importance of relational values as a foundation for environmental stewardship and contribute to a novel understa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Probabilistic Argumentation on the Web' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The (World Wide) Web hosts a wide range of argumentative text from resources of multiple disciplines and online debates. Also, tools (such as Debadepedia and Twitter) encourage the communication of arguments in social and scientific settings. With the exponential growth of the Web and its users, a vast amount of argumentative text on the Web remains hidden. In order to query the Web for structured arguments included in web pages, it is necessary to address both of the following issues: (1) the deployment of technologies that enable an automatic extraction of the components of natural language arguments and the representation of their meaning and (2) the deployment of a pragmatic argumentation formalism that takes into account the uncertain and inconsistent nature of data on the Web to reason with structured arguments. State-of-the-art research in natural language processing (NLP) recently engaged in the deployment of technologies for learning the semantic similarity between statements and for the extraction of probabilistic beliefs and logic expressions from natural language text. This is a promising direction forward, toward the automatic extraction of the components of argumentative text online. Additionally, research on probabilistic formalisms supporting argumentation reasoning is at the heart of state-of-the-art research in knowledge representation and reasoning (KRR). The goal of the “ARGUE_WEB” project is to develop a scalable probabilistic argumentation system for the retrieval, for the  principled management of points of view derived from argumentative text on web pages, and  for query answering from such points of view. One of the central aspects of this scalable approach is the representation of structured arguments using an ontology language and the developm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Robust self-testing with applications to device-independent cryptography'.

assistant: **Concept**

The quantum revolution is happening now. Every day experimentalists around the world produce more complex, reliable and powerful quantum devices which take us one step closer to quantum computation, communication and cryptography. Testing is a crucial part of the development process necessary to ensure suitability of the device for the application in mind. Methods used for small devices quickly become impractical, as the devices become more complex and we need to develop efficient and robust testing procedures in order to make further progress. Fortunately, quantum physics is well-suited for this task, as it allows to precisely characterise devices under surprisingly weak assumptions. This feature, known as self-testing, is intrinsically related to the fundamental concept of Bell inequalities. The goal of this proposal is to develop efficient and robust testing procedures for complex quantum devices based on Bell's theorem. In the short-term these will allow experimentalists to efficiently characterise their devices, while in the long-term they will enable a customer to certify that a newly bought quantum device adheres to the specification, which opens the door to device-independent information processing. The timeliness of this proposal is demonstrated by the fact that the first loophole-free Bell experiments were reported within the last year. On top of practical applications, self-testing is important from the foundational point of view. By exploring the intimate connection between the quantum (microscopic) world of Hilbert spaces and the classical (macroscopic) world of resulting probability distributions, it provides the unique link between what we see and what is happening at the quantum level. This fellowship will allow Jędrzej Kaniewski to work under the superv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Developing crossflow membrane emulsification for the food industry (FOOD XME)' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Many processed foods are emulsion based, containing micron-sized droplets to impart texture, flavour, stability, and quality to a range of products. However, current emulsification methods are not well controlled or energy efficient. Crossflow Membrane Em ulsification (XME) makes improved quality emulsions, is both cost and energy efficient. initiallaboratory results require development to scale up, optimise and exploit the technology. This research will also define generic requirements which will be valuab le to the pharmaceutical, cosmetic and agrochemical sectors. XME performance relies on the interfacial properties of the emulsifiers. Therefore the project will define the interfacial properties and hence the emulsifiers best suited to XME technology. The project comprises two main stages: Stage 1: Laboratory scale XME will test a range of ingredients, model foods and process engineering parameters. Emulsions will be characterised and the added value over conventional emulsions evaluated. The interfacial properties of the ingredients and products will be characterised and correlated with XME performance. Stage 2: Ingredients and products will be modified or developed for pilot scale testing. Pilot scale apparatus design will be based on the stage 1 trials. This will enable scaling up of both the process, and the correlation between interfacial properties and XME performance. The added benefits of emulsions produced using XME (i.e. improved rheology, stability and sensory properties) over conventional food p roducts will be quantified. The results from the interfacial studies will be used to develop a predictive test to screen emulsifiers for use with XME. The creation of novel multiple emulsions, which can be used to encapsulating active ingredients or redu cing the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Rehabilitation of a discrete sensory motor learning function by a prosthetic chip'.

assistant: **Objectives**

The objective of this project is to develop a full biohybrid rehabilitation and substitution methodology; replacing the aged cerebellar brain circuit with a biomimetic chip bidirectionally interfaced to the inputs and outputs of the system. Information processing will interface with the cerebellum to actuate a normal, real-time functional behavioural recovery, providing a proof-of-concept test for the functional rehabilitation of more complex neuronal systems.<br/><br/>The model neuronal system we have chosen is the cerebellar microcircuit involved in conditioning of the motor eyeblink response. Localized experimental or clinical damage to this microcircuit disrupts irreversibly the eyeblink conditioning while aging invariably compromises the acquisition and retention of the eyeblink response. <br/><br/>Using the aged rat as an experimental model we plan to integrate a biomimetic chip to rehabilitate a discrete sensory-motor learning function lost in the senescent cerebellar microcircuit, through the development of multiple enabling technologies.   <br/><br/>We will develop novel electrodes to both detect the stimulus and trigger the eyeblink response. The stimulus signals will be extracted from background neuronal activity and undergo conditioning, processing and interpretation in a silicon chip which mimics the function of the deficient cerebellar circuit. The output from this biomimetic chip will then trigger the eyeblink response by way of implanted stimulation electrodes.<br/><br/>Complete success would be achieved through real-time demonstration of functional recovery of the lost motor learning response in aged rats. Advances in any or all of the component technologies, their integration and clinical implementation, and improved understanding of the neuronal circu