RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Silk Project Operations, Networking and GEANT Extension' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The SILK Project will provide a satellite-based extension to GEANT for eight Former Soviet Union (FSU) republics, connecting in their NRENs. This SPONGE project will enable EC persons to assist FSU academics get the best out of a NATO funded 4MEuro grant for SILK. The original grant may not be spent on the items given here, which are vitally needed to make SILK a success. SPONGE will provide Project Management for SILK. It will also provide measurement services (in conjunction with the Georgian partner) to ensure that requisite QoS is achieved. It will ensure (with the Armenian partner) that appropriate personal communications services could be made available (voice/IP and multimedia conferencing) to improve personal communications for SILK. Finally it will provide information services, disseminate information about SILK activities, and try to ensure ongoing financial support from outside NATO at the end of their funding after 2004.OBJECTIVESThe NATO Science Committee has awarded a grant (SILK) for the provision of a VSAT-based network, which will provide GEANT access for the NRENs of the newly independent states (NIS) of the Southern Caucuses and Central Asia. Additional grants provide for operating the VSAT hub, LAN equipment for connecting the NRENs and special tariffs for the satellite bandwidth. None of this may be spent on European staff. The SPONGE Project is a complementary initiative that will ensure a maximum benefit for NIS grantees; SPONGE will provide overall management for SILK, infrastructure services needed (like documentation, a web site and information services), and training help. Technical structures will provide performance information on the system, and mechanisms for optimal tuning. Under SPONGE we will explore mechanisms for providing better pers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Syntactic Flexibility in Developmental Language Disorder. A Cross-Linguistic Study.'.

assistant: **Innovation**

The project aims to advance theoretical and practical knowledge in psycholinguistics and developmental neuroscience, focusing on symptoms of Developmental Language Disorder (DLD). Specifically, I will investigate underlying cognitive factors of syntactic difficulties manifested by children with DLD. I will test the project's hypotheses regarding the inflexibility of statistical learning of syntactic structures in DLD. To this end, I will examine the production and comprehension of relative clauses (RCs) in Italian- and Polish-speaking children with DLD. The RC is a subordinate clause that exhibits different syntactic structures in Italian and Polish. Therefore, the cross-linguistic study will provide a quantitative analysis of local linguistic elements that signify thematic role assignments in RCs and distinguish between Italian (IT) and Polish (PL). Additionally, I will analyze the global RC sentence structure, including length, complexity, and the distance related to syntactic movement. This linguistic analysis will further allow testing of the hypothesis that basic cognitive components and their interactions contribute to the errors typical for children with DLD. Specifically, based on linguistic analysis, I will test neuropsychological hypotheses that the following cognitive elements contribute to DLD deficits: i) executive control, triggered by the probabilistic properties of word/morpheme flow within the sentence; ii) performance in encoding rare linguistic elements, as reflected in inflectional suffixes; iii) working memory load, related to sentence length and syntactic movement. The achievement of the project's aims will impact the international research community by providing new insights into the cognitive aspects of language skills, particularly the developme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Microbial invasion and dissemination within the host, mechanisms and effects' (INVADIS).

assistant: **Innovation**

An infection is defined by the deleterious consequences of the interactions between a pathogen and a host. Thus, studying the biology of infection reveals critical properties of hosts and pathogens, and is a way forward to address basic biological questions and improve health.We study listeriosis, a systemic infection caused by Listeria monocytogenes (Lm). Lm is a human foodborne pathogen that crosses the intestinal barrier, disseminates systemically, replicates in liver and spleen and reaches the central nervous system (CNS) and fetoplacental unit. Given the remarkable journey Lm makes in its host, studying listeriosis offers unprecedented opportunities to understand host cell biology, physiology and immune responses, guided by Lm. The mucosal, CNS and fetoplacental tropisms of Lm are shared by other microbes which pathogenesis is far less understood. Lm therefore stands as a unique model microorganism of general biological and medical significance.The major challenge of this project is to go beyond reductionist approaches and embrace the complexity of actual infections.We will use stem cell-derived organoids, live imaging, genetically engineered mouse models, the clinical and biological data from a unique cohort of 900 patients and the corresponding causative Lm strains, to investigate the molecular mechanisms of Lm tissue invasion, dissemination and host responses.Specifically, we will (i) decipher the cell biology of microbial translocation across the intestinal epithelium; (ii) study the impact of microbial portal of entry on microbial fate, dissemination and host responses; (iii) harness Lm biodiversity to identify novel virulence factors and (iv) discover new host factors predisposing to invasive infections.Building on the unique combination of advanced experimen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Constructive Mathematics: Proof and Computation' (CONSTRUMATH) targeting Seventh Framework.

assistant: **Abstract**

The proposed programme focusses on constructive analysis, algebra and topology, the extraction and implementation of programs from formal proofs, and constructive reverse mathematics. Through a network of three European and two third-country institutes, all of them among the leading groups in the relevant research, we aim at facilitating the interplay between the above branches of constructive mathematics, which range from the foundations of mathematics to real-world applications in computer science.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'URBAN PROSUMERS – towards a knowledge transfer hub for empowering citizens as producers and consumers of sustainable solutions to climate-neutrality' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

The URBAN PROSUMERS project supports the implementation of EU’s Climate Neutral and Smart Cities Mission at the local level in Tampere Region, Finland. This initiative strengthens and enhances the role of local Higher Education Institutions (HEIs) as focal actors of transdisciplinary research and action in sustainability issues. By leveraging citizen science and participatory research methods, the project actively involves Tampere residents and local stakeholders in developing solutions focused on sustainable mobility, food systems and energy. Through co-creation, the project builds a knowledge transfer hub around the topic of sustainable urban prosumerism.The title “URBAN PROSUMERS” highlights the project’s goal to engage residents as both producers and consumers of sustainable solutions, services and knowledge. Through novel participatory infrastructures and a co-creation process guided by HEIs, the project brings together the city, residents, and various actors to identify local needs related to the Mission themes. It funds community experiments that seek social or technological innovations within the three key thematic areas of the project (mobility, food and energy), addressing the needs identified by residents and local entities such as NGOs, associations and city administration.Tampere HEIs play a crucial role by developing and managing a new knowledge transfer hub for sustainable urban prosumerism, integrating this process also into their strategic work. The project aims to create a novel theoretical understanding of the urban prosumerism model through co-creation and experimental community projects. This model can serve as an example for participatory climate action in cities, with potential for scaling and replication in other Mission cities across Finland and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A Mechanistic Variant Effect Predictor for disentangling the biophysical mechanisms driving disease' to be submitted under Horizon Europe.

assistant: **Abstract**

Genome sequencing has grown exponentially, but determining the phenotypic consequences of mutations remains a key challenge in human genetics. Recently, unsupervised methods, which model the distribution of sequence variation across organisms, have emerged as promising tools for quantifying the clinical pathogenicity of variants, rivaling the accuracy of experimental approaches. However, these machine learning predictors fall short in discerning the effects induced by pathogenic mutations that impact on organismal fitness and drive disease. I propose to address this knowledge gap by combining the evolutionary-based variant tolerance predictors with protein folding models derived from energy landscape theory. In order to fold in biological timescales, an amino acid chain must minimize energy conflicts within it. In natural proteins, remaining conflicts can be measured with a transferable energy function, pointing out regions that did not evolve maintaining foldability, as active or binding sites. Incorporating this approach, I will focus on disentangling the biophysical ambiguity between the alteration of specific functions and local stability changes along proteins, firstly for single variants from which thermodynamic data is available for testing. Furthermore, I will integrate the folding and evolutionary models into a single algorithm to characterize and predict disease-driving mechanisms along the human proteome, a Mechanistic Variant Effect Predictor (mechVEP). Finally, I will apply this pipeline for investigating the epistatic and dominance effects of multiple mutations, paving the way for fine-tuning disease predictors for different ancestries. In summary, findings from this study will provide completely new insight into deciphering the underlying molecular mechan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Investigating the Therapeutic Potential of Persulfides: Implications of their Roles in Cardiovascular Disease' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cardiovascular disease (CVD) is the number one most fatal disease worldwide and despite many efforts, there is still no current treatment. Thus, the discovery of novel therapeutics to treat CVD is critical. Persulfides are biologically-relevant sulfur species that display much therapeutic potential in a variety of human disease, including CVD. Importantly, persulfides are potent scavengers of many disease-associated oxidants and electrophiles, making persulfides potentially relevant in the etiology of such diseases. Unfortunately, the reactive nature of persulfides makes their study difficult and reliant on the use of donor compounds. As a result, various persulfide donors have been developed, though these too often lack stability and are mostly biologically-irrelevant. Therefore, to address these issues, I discovered a novel persulfide donor, cysteine trisulfide (Cys-SSS-Cys).         Cys-SSS-Cys is a stable biologically relevant molecule that upon reduction, releases cysteine persulfide (Cys-SSH), which is also a biologically relevant species. Thus, I hypothesize Cys-SSS-Cys is an ideal persulfide donor to study the therapeutic properties of persulfides, and that Cys-SSS-Cys will prove to be a novel therapeutic for the prevention and/or treatment of CVD. To assess this, I will examine effects of Cys-SSS-Cys on cellular, tissue and whole animal models displaying symptoms of CVD. First, I will identify mechanisms for cellular uptake and intracellular reduction of Cys-SSS-Cys to afford Cys-SSH. Next, I will measure the ability for Cys-SSS-Cys to prevent/treat markers associated with CVD in cells and tissue. Lastly, I will evaluate whether Cys-SSS-Cys serves as a therapeutic for CVD in whole animal models. Altogether, this research aims to identify Cys-SSS-Cys as a novel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'An environment for improving the industrial experiment feedback process' (NOEMIE), addressing dissemination and exploitation.

assistant: **Impact**

Today, corporate knowledge of large industrial European Companies is scattered amongst many databases at different geographical locations. For example : engineering and manufacturing databases that contain data about the design and the production of a product, field databases that contain information about the product usage at the end-user's site and problems encountered etc., financial data base, safety data bases, marketing data bases...Existing legacy databases were usually constructed for the purpose of storing and managing administrative information, and are targeted for specific uses and for specific needs. In today's rapidly changing world, and in order to enter the information society, it becomes increasingly important to improve the decision process by making better use of this scattered information.Although it is technically possible to physically access data at remote locations, it is difficult to correlate the information in these different legacy databases. In an ideal environment , one would like to have a single database that serves the purpose of everyone (i.e. engineering, manufacturing, marketing, field operations etc...). In practice, due to the great variety of specific uses, it is impossible to create a single database that corresponds to everyone's needs.The present project, NOEMIE, aims at facilitating experience feedback between different organizations in order to improve the decision making process. Leading edge information technologies, such as Case-Based Reasoning and Data Mining, coupled with some business process re-engineering, will allow to make a global reuse of corporate knowledge distributed amongst legacy databases.The goal of NOEMIE is to develop a methodology and tools for automated reuse of industrial experience from large collectio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Amsterdam Rheumatology Center for AutoImmune Diseases' in the context of a Horizon 2020 call.

assistant: **Objectives**

Autoimmune rheumatological diseases such as rheumatoid arthritis, spondyloarthritis, vasculitis and systemic lupus erythematosus continue to exert significant tolls on the quality of life of millions of afflicted patients and on European societies in the form of loss of (work-)productivity and costs. Major advances in our understanding of the immunological processes underlying these diseases have been made, but it has not always been possible to translate these to improved diagnostics or therapeutic health care interventions. At the AMC and collaborating institutions and partners, we have developed the translational platforms for true bench-to-bedside development of the next generation of diagnostics and therapeutics for these diseases.  To contribute to this effort, the next generation of scientists that work on translational immunological rheumatology need to be educated. Therefore, a multidisciplinary research team of scientists based at several faculties at Amsterdam UMC, The Netherlands are applying for a Marie Skłodowska-Curie COFUND grant. In this programme, 20 PhD students will work in the field of translational immunological rheumatology. The ARCAID applicants at the Amsterdam UMC consist of leading and renowned research groups on this subject and we are confident that these groups can achieve the ambitious goals of the program.


**Keywords:** Immunology, Rheumatic diseases, Translational research, Diagnostics, Prognostics, Therapy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Colonic Disease Investigation by Robotic Hydro-colonoscopy' in the context of a Seventh Framework call.

assistant: **Objectives**

CODIR proposes a new configuration of fundamental and applied biomedical and engineering multidisciplinary research to explore and characterise colon behavior necessary for the project and wider objectives. Scope and focus is on novel robotic hydro-colonoscopy (RHC), which stems from two considerations: (i) replacement of the flexible colonosocope with a patient-friendly system for inspection of the mucosal surface colon and (ii) the very recent concept of  hydro-colonoscopy whereby water is used instead of traditional air insufflation.  RHC can enable a breakthrough in patient-compliant complete endoscopic examination and biopsy of the colon for the further study of life threatening disorders of the colon commonly categorized as inflmmatory bowel disease, all of unknown aetilogy despite intensive research. CODIR will provide new insights for biomedical investigation and research applicable to many biomedical fields: biologic [absorption of water and electrolyte from the colon, characterisation of surface topograpgy of the colon,  mechanical properties of colonic wall], imaging, mechatronics robot functionality and a novel colonic irrigation and filling system. The ambition is to develop a one-stop holistic system which cleans the colon of faecal debris and then introduces a tethered swimming/ submerging robot for inspection of  the mucosal aspect of colon under the control of a clinician operating the endoluminal mini-robot from  a control console. A secondary, very important outcome of CODIR is to increase patient compliance (currently 50%) for screening colonoscopy in early diagnosis of colorectal cancer, the worlds second commonest cancer. RHC can overcome major disadvantages of existing colonoscopy examination: discomfort, sedation, thus increasing compliance and e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Tree water use under changing snow/rain seasonality: The forgotten tree-induced upward preferential flow in boreal soils' (BoTWU) under Horizon Europe.

assistant: **Objectives**

The project ‘Tree water use under changing snow/rain seasonality: The forgotten tree-induced upward fast flow in boreal soils’ aims to go beyond the state-of-the-art in boreal tree water use (TWU) research by (1) challenging the fundamental TWU assumption of no water isotope fractionation along the boreal TWU pathway, (2) unravelling the hydrological importance of the forgotten ‘upwards preferential flow’ in boreal forest soil, and (3) being the first to systematically consider biophysical impacts of changing snow and rain on TWU from the root level to individual level. Under the supervision of Prof. Hannu Marttila (University of Oulu), these aims will be supported by an innovative experiment set-up (high-resolution water isotopes and bi-directional fluxes on roots to stems) and up-to-date methodology and instruments (in-situ non-destructive Water Isotope Probes, Picarro L2140-I isotope analyzer, heat-plus-method sap flow sensors), where the research will be conducted in a boreal forest near the Arctic Circle on three typical boreal species with manipulated snowpack depth. During the project, my expertise in (eco)hydrology will expand from temperate forests and sap flow techniques to boreal forests and stable water isotope techniques, which will be a stepping stone in my long-term academic career plan for becoming a leading and independent ecohydrologist. Meanwhile, my know-how in tree transpiration and tree ecophysiology complements the expertise in northern hydrology at UOULU. The proposed dissemination, exploitation, and communication measures and activities will significantly impact the ecohydrology community and will subsequently contribute to improving sustainable-use, climate-smart forest and water resource management benefitting forest and water resource related