RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Beyond Modification: Defining Hidden Roles of snoRNPs in Ribosome Assembly'.

assistant: **Concept**

The assembly of new ribosomes is a conserved and tightly regulated process required for the growth of all living beings. Successful ribosome production requires the coordinated action of hundreds of cellular factors, including small nucleolar ribonucleoprotein particles (snoRNPs). Human snoRNP defects or alterations in snoRNP expression are linked to bone marrow disorders, neurodegeneration, and cancer. We recently discovered that a specialized class of snoRNPs play central yet underappreciated roles in orchestrating the earliest events of ribosome assembly, beyond their well-known function of directing rRNA modification. These specialized snoRNPs, which we termed assembly-promoting (ap-)snoRNPs, possess unique RNA and protein components that we hypothesize empower each snoRNP to guide a specific step of ribosome assembly, thereby ensuring that new ribosomes are properly made. Their constituents, 3D structures, dynamics and mechanism of action are virtually unknown. This synergistic research consortium will define the functions of this newly discovered class of snoRNPs by integrating recent advances in genetics, high-throughput RNA biochemistry, cryo-electron microscopy and single molecule biophysics. The goals of this research project are to inventory yeast and human ap-snoRNPs that act in ribosome assembly, determine their components and 3D structures, define their biological functions, and unravel the physical mechanisms by which they promote ribosome assembly. Highly complementary approaches and a broad program of discovery will mitigate the risks associated with this challenge. The results of this collaborative research are expected to change the current view of snoRNP function and provide a comprehensive platform for understanding how snoRNPs promote ribosome asse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Auxiliary factors involved in the post-transcriptional regulation of microRNA expression.' (2007-2013).

assistant: **Innovation**

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression of complementary mRNAs. They have diverse unique expression patterns and have been implicate in a number of biological processes. It has been shown that in many physiological and pathological conditions individual miRNAs are subjected to post-transcriptional regulation, both at the level of Drosha and/or Dicer processing. The host lab has recently found that hnRNP A1, a protein implicated in many aspects of RNA processing, act as an auxiliary factor for the Drosha-mediated processing of a microRNA precursor, pri-miR-18a. hnRNP A1 binds to the loop of this pri-miRNA and induces a relaxation at the stem creating a more favourable cleavage site for Drosha. Our first objective is to define the functional domains in hnRNP A1 that are required for miR-18a processing. Thus, we will determine whether RNA binding and/or the unwinding activities of hnRNP A1 are required for miR-18a processing. The host lab also found that approximately 14% of all pri-miRNAs have highly conserved loops suggesting that these conserved loops act as landing pads for trans-acting factors influencing miRNA processing. In order to address the question of how widespread is the contribution of hnRNP A1 and other auxiliary factors to pri-miRNA processing I propose to identify other microRNAs that require hnRNP A1 for their processing. Secondly, I plan to identify different auxiliary factors required for the processing of microRNAs containing a conserved terminal loop by affinity pull-down assays followed by peptide mass fingerprint analysis. In summary, experiments carried out in this proposal will reveal the level of complexity for the regulation of microRNA biogenesis and their contribution to physiological states and p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'COMbined Passive and Active Flow Control Technology Wing' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The aim of this project is to design and manufacture a large Hybrid Laminar Flow Control (HLFC) half model, representative of a civil transport aircraft wing, for installation in the ONERA S1MA tunnel.  The model will be capable of testing the effectiveness of laminar flow control devices at transonic speeds (M~0.85) and high Reynolds number (>10x10x6/m).  The model will incorporate systems for delaying transition in the leading edge region over 2 spanwise sections.  The outer section will address the HLFC requirements, using either active suction through the surface of the porous wing leading edge and or passive control.  The active suction control methods will consist of a porous skin and the wing will incorporate pipework permitting suction to be applied through the porous surface using a suction source provided by the wind tunnel.  The location of boundary layer transition at each section will be measured using the IR technique and the upper wing surface will therefore include an insulating material for the measurement of transition using IR thermography.  As with all HLFC models, the surface finish will be very high quality with no steps or gaps.  The suction system and instrumentation will be fully tested prior to delivery of the model.  The inboard part of the wing will be equipped with both passive and active (wall suction) anti-contamination devices to investigate ways to control attachment line transition.  The model will be fitted with a range of instrumentation including pressure tappings, unsteady pressure transducers, accelerometers, strain gauges and possibly hot films, all of which will be thoroughly tested during final assembly.  Finally, on completion of the model assembly, the model deformation due to representative applied static loads will be measur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cell-mediated sculptable living platforms as highly efficient hybrid units to bioengineer human microtissues' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Geometrical, mechanical, and biochemical signals are master regulators of differentiation and other cellular processes. Biomaterials have been used to create artificial 3D niches recapitulating such favourable cues, traditionally optimized through progressive and laborious design-build-test-learn cycles. In native environments, however, cells dynamically interact and modify their surroundings, engaging in feedback loops that alter their phenotype and trigger collective effects. Based on such principles, and leveraged by a unique synergy between biomaterials, synthetic biology, and computer modelling, RODIN proposes a transformative approach by engineering biomaterial units based on flexible, micro-sized films that allow stem cells to autonomously sculpt their environments. These hybrid structures (pockets), formed through crumpling or origami-like folding, will create diverse internal milieus for cells to freely explore. We hypothesise that the microenvironment in the pockets can be moulded for a targeted cell phenotype based on local material properties and biochemical differentiation factors. To test this, films will be made from bioactive human-derived proteins or nanocellulose. In the latter, engineered microbes programmed to secrete specific factors will be embedded within the films to create a living platform able to guide stem cells toward osteogenic differentiation. Cell behaviour will be correlated with local structural data from the pockets and analysed using deep learning to identify favourable geometrical and structural descriptors that could help to engineer bioactive improbable synthetic niches. Computer modelling will identify optimal conditions for producing high-quality microtissues, with applications in regenerative medicine and pre-clinical disease mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Manure-to-energy and organic fertilizers solution: smart eco-technology for efficient and sustainable farming, through valorisation of manure' (SUSTAINABLEFARM) targeting Horizon 2020.

assistant: **Abstract**

The livestock sector currently constitutes the world’s largest user of natural resources: with 80% of all agricultural land used for grazing or animal feed production and 8% of the global water use, primarily for irrigation of feed crops. Livestock farming contributes 18% of human produced greenhouse gas emissions worldwide including agricultural waste products accounting for 10% of greenhouse gas emissions. The EU alone produces 1.4 billion tonnes of manure per year. Yes, most of the farmers have no access to robust solutions to manage manure in a sustainable and cost effective way. Further, there is an increasing pressure on land use and environmental regulations aimed at ensuring good agricultural and environmental agricultural practices. The SustainableFarm innovative solution aims to reduce environmental impact of livestock farming through providing farmers solutions to operate sustainably by using integrated affordable, modular and scalable waste-to-energy platform, able to able to convert manure into biogas and organic fertilizers, with the right nutritional properties for their farms (unlike manure which brings a number of disadvantages). The developed solution and opportunities provided through this project will allow us to acquire an innovation associate able to address some of the existing technical challenges of our SustainableFarm innovative disruptive solution in livestock farming market worth around €27bn in EU.EcoNomad Solutions aims to reduce environmental impact of livestock farming through providing farmers with eco-technological solutions for agricultural waste reduction and sustainable resource management. SustainableFarm will contribute to our innovation capacity enhancement and resourcefulness to deliver our latest proprietary manure-to-energy and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Microbial translocation across host barriers', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Infections remain the primary cause of mortality in humans. New infections are emerging, and resistance to antimicrobial drugs is widespread and expanding. There is thus an urgent need to develop novel therapeutic strategies based on rationally-designed drugs blocking the pathogenic effects of microbes on the host. A prerequisite for this is a complete understanding of the pathophysiology of infectious diseases. Systemic infections result from the invasion of hosts by a microbial pathogens, and a critical pathogenic determinant is thus microbial translocation from the external environment into the host and dissemination to protected tissues such as the central nervous system and the fetus. Our project is focused on understanding the molecular mechanisms underlying the ability of certain microbes to cross the intestinal barrier, the blood-brain barrier and/or the placental barrier. Specifically, we will pursue the following objectives: (i) understand how invasive pathogens adhere to host barriers, (ii) understand how invasive pathogens cross cell monolayer barriers, (iii) determine microbial fate and dynamics within the host, and (iv) determine how host responses influence barrier vulnerability to invasive pathogens. Because we will address these biological questions in a tissue and whole-host context, this project will integrate in vitro, ex vivo, and in vivo approaches. It will allow us to address questions in a novel dimension, defining a transition from cellular microbiology to tissular microbiology. Completion of our objectives will provide critical information on key pathophysiological steps critical for the understanding of microbial pathogenesis, and will also improve our basic knowledge of host barriers biology during homeostasis and upon microbial aggression.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Hardware Acceleration for Computing on Encrypted Data' in the context of a Horizon 2020 call.

assistant: **Objectives**

Electronics are part of all aspects of our daily life, at home, at work, while on the road. Smart cities, medical devices, financial transactions, self-driving cars, all rely on electronics. At the same time, these activities generate huge amounts of data, which for privacy and security reasons, are stored encrypted on a possibly untrusted cloud server. Yet, many applications benefit from operations on this data. Statistics or machine learning on medical, financial, automotive or energy data could discover trends or abuse, could be used to monitor pandemics, to tune supply and demand, and much more. Ideally, the calculations on the data should be done without decrypting them first to avoid data leaks.  Computing on encrypted data is the new magic in the field of cryptography: it enables calculations on the encrypted data, while data remains encrypted in the cloud and without the need to decrypt it. The result will only be decrypted by the final recipient. Challenging in these novel mathematical concepts is a gigantic blow-up in the size of ciphertext data, in the amount of calculations on the encrypted data, and in the novel lattice based arithmetic used. The core challenge addressed in BELFORT is to make this new technology feasible from a hardware perspective and in realistic scenarios, providing the best performance/energy balance, for it to run on cloud servers and edge devices, within reasonable memory, computation and energy budgets. We propose reconfigurable hardware-based acceleration with domain-specific programmable co-processors, which combine energy efficiency with domain specific programmability and with resistance to attacks from classic and quantum computers. We will develop multiple new ideas as well as bring them together in an end-to-end demonstrator.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bridging the gap: from Individual Behaviour to the Socio-tEchnical MaN' (IBSEN) under Horizon 2020.

assistant: **Objectives**

Developing models of real-world societal scenarios and systems is a key topic in the research agenda of social sciences, but is hindered by the lack of controlled experimentation with large groups of people. IBSEN will provide a breakthrough by building a repertoire of human behaviour in large (1000+ persons) structured groups using controlled experiments. To that end, we will develop a novel setup for large groups of people that will provide an experimental protocol, the necessary software and analytical tools to allow us to deal with thousands of people at the same time. We will apply our setup to specific research questions, focusing on novel phenomenology that may arise in large systems as compared to typical smaller ones, to find the rules that govern human behaviour in those cases, including the influence of social context and individual identity on them. We will assess our approach by building a model of human interaction in groups based on the behavioural rules we have found. The project requires a high-degree of interdisciplinarity; accordingly, the team consists of physicists, economists, social psychologists, and computer scientists. On the other hand, this is a high-risk project, as the experimental design may prove unfeasible for really large systems and extracting meaningful data from the participants’ actions may not be possible. Notwithstanding, encouraging results in some pilot studies run by partners underpin the scientific feasibility of the concept and approach. If successful, researchers will be able to build on our findings to develop a human behaviour simulator, a technology providing a basis for socio-economic simulations that would radically change many fields, from robotics to economics, with technological and societal impacts, including policy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deep Forestry Drones - revolutionising forestry mapping and analysis with artificial intelligence' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Forestry mapping is key for the economy, yet most of the mapping work is manual today, allowing assessments of only 5-10% of trees. The results of improper forestry mapping range from the inability to react to crisis events such as wildfires or diseases, lower productivity and inaccurate valuations. To solve this problem, many companies have launched mobile phone-based platforms and above canopy LiDAR or photogrammetry, but these products often come with several drawbacks, e.g. they do not provide an accurate understanding of the most desirable forestry characteristics such as wood value (quality) class, species type, volume estimation and bad wood estimates. They are also unable to provide a detailed map of the terrain (boggy areas, small streams, boulders, dead-wood, fallen trees, etc.). These drawbacks cause the existing solutions to become difficult to use and time-consuming, while providing very little added advantage over traditional methods. In turn, this forces companies to create less value and leads to smaller ROI.Deep Forestry AB built the first agile, light-weight, autonomous drone to fly below the canopy of commercial forests, that is, in-between the trees. Flying below the canopy provides our customers with analytical tools which were previously unavailable: precision analytics, robust classification algorithms, and optimized harvesting routes. They will help companies to cut their costs and increase revenue while mitigating risks and eliminating human error. Our new (Drone + AI) technology will provide more data to the front-end of the forestry value chain than has ever been thought possible.The key objective of our project is to transform an initial business plan into a robust strategy for international commercialization. With this goal in mind, our Phas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Commercialization of distributed & cloud solutions for biomolecular simulation and free energy calculation' (BINARYBIO), addressing dissemination and exploitation.

assistant: **Impact**

Computational chemistry is playing an increasingly important role for research in the pharmaceutical industry, oils & plastic, and materials development. Simulation and high-throughput screening can be orders of magnitude cheaper than experiments in the early stages of drug design. The ERC project preceding this application has developed several new techniques that make it orders-of-magnitude more efficient to calculate free energies from simulations rather than approximate docking screening. We have already had great academic success, but the requirement of large computer clusters or access to the Folding@Home network makes it difficult to implement in industry.To address this, we have developed a new framework for peer-to-peer distributed computing combined with Markov state models (called “Copernicus”) to be presented at Supercomputing’11. Copernicus completely removes the need to deal with single simulations, and allows users to specify workflows - directly on their laptop - in terms of free energy calculations or sampling of complex processes such as protein folding. Workflows are transparently uploaded to a server and split into distributed calculation workunits (e.g. in a company), computer clusters, but also cloud computing to deal with peaks in usage. The results are again transparently moved to the user’s machine.This provides a clear competitive advantage in terms of efficiency, and it removes all investment and support costs related to high-performance computing. This is of course not limited to molecular simulation, and in addition to the pharmaceutical track we want to investigate usage in the financial industry. We have just submitted a patent application for the dynamic data flow network that makes the peer-to-peer usage possible, but we would need a pro