RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Engineering Yarrowia lipolytica for photoautotrophic growth by integrating light-driven energy generation with synthetic CO2 fixation to enable sustainable bioproduction' (YarroSynLight).

assistant: **Concept**

The accelerating climate and energy crisis, driven by rising CO2 emissions and fossil fuel depletion, highlights the urgent need for renewable solutions. Disruptive biotechnologies are required to both mitigate greenhouse gases and enable sustainable chemical production. Conventional microbial production systems rely on sugar-based feedstocks, which face scalability and efficiency constraints. Phototrophic microbes such as cyanobacteria offer an alternative but remain limited by slow growth, low productivity, and genetic intractability. The objective of YarroSynLight is to establish Yarrowia lipolytica as a novel photoautotrophic platform organism by integrating light-driven energy generation with synthetic carbon fixation, thereby creating a carbon-negative microbial cell factory. This will be achieved through a structured work plan: building a robust phototrophic chassis, coupling energy and carbon assimilation pathways, optimising metabolic fluxes with systems-level tools, and directing assimilated carbon toward high-value biochemical production. These steps will be validated under scalable bioreactor conditions using simulated flue gas, ensuring robustness, techno-economic feasibility, and environmental relevance. The project aligns closely with the MSCA Work Programme by addressing pressing climate challenges while equipping the researcher with advanced skills in synthetic biology, metabolic engineering, and bioprocess development. Training, mentoring, and two-way knowledge transfer at Imperial College London will support career independence, while dissemination, outreach, and engagement with stakeholders will maximise impact. Ultimately, YarroSynLight will deliver a transformative route for solar-powered, carbon-negative biomanufacturing, contributing directly to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Generic Fuel Cell Modelling Environment' (GENFC) targeting Sixth Framework.

assistant: **Abstract**

The GenFC proposal addresses the topic 'Generic tools for FC systems modelling, testing, safety and quality assurance' under the activity code SUSTDEV-1.2.1: Fuel cells including their applications. It falls into research activities having an impact in the medium to long term. The overall goal of GenFC is to provide a generic modelling tool to fuel cell and fuel cell systems developers making fuel cell modelling expert knowledge available to all of them. The fuel cell and fuel cell systems developers can us e this tool to improve and accelerate fuel cell development and to contribute to a future success of the fuel cell technology. It is believed that from the fuel cell (hardware) developer's point of view, a fuel cell modelling environment is desirable which can be used for simulation tasks exactly catering to the demand of the application engineer. The integrated modelling tool will assist fuel cell developers to improve their design- and optimisation processes in terms of accelerating development cycles, l owering costs, improving quality and hence also safety. The user of such a modelling environment will be able to choose through a user friendly interface a model out of a set of different types of fuel cells. Each type of fuel cell will be available in dif ferent implementations and each implementation is suitable for a particular application. The consortium consists of fuel cell technology developers, specific software providers, software engineers and fuel cell model users. Existing and in the course of t he project to be developed models and hardware in the loop systems for different types of fuel cells on all levels from system integration, via stack and cell down to electrode processes, are integrated in the tool and interfaced with a common data-base fo r pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Designing eTrading Solutions for Electricity Balancing and Redispatching in Europe' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Four European TSOs of Central-Eastern Europe (Austria, Hungary, Romania, Slovenia), associated with power system experts, electricity retailers, IT providers and renewable electricity providers, propose to design a unique regional cooperation scheme: it aims at opening Balancing and Redispatching markets to new sources of flexibility and supporting such sources to act on such markets competitively. Thanks to a prototype aggregation solution and renewable generation forecasting techniques, flexibility providers – distributed generators (DG) and Commercial and Industrial (C&I) consumers providing demand response (DR) – are enabled, through retailers acting as flexibility aggregators, to provide competitive offers for Frequency Restoration Reserve (including secondary control activated with a response time between 30 seconds and 15 minutes). A comprehensive techno-economic model for the cross-border integration of such services involves a common activation function (CAF) tailored to congested borders and optimized to overcome critical intra-regional barriers. The resulting CAF is implemented into a prototype Regional Balancing and Redispatching Platform, securely integrated within the four TSOs’ IT systems: this makes research activities about cross-border integration flexible while linking with the aggregation solution. Use cases of growing complexity are pilot tested, going from the involvement of DR and DG into national balancing markets to cross-border competition between flexibility aggregators. Based on past experience with tertiary reserve, participating C&I consumers and DG are expected to provide close to 40MW of secondary reserve. Impact analyses of the pilot tests together with dissemination activities towards all the stakeholders of the electricity value chain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A novel concept of an extremely short take off and landing all-surface (ESTOLAS) hybrid aircraft: from a light passenger aircraft to a very high payload cargo/passenger version' (ESTOLAS) targeting Seventh Framework.

assistant: **Abstract**

The concept of the project is to develop and validate the conceptual design of a hybrid aircraft – a flying device combining the best qualities of an airship, a plane, a helicopter and a hovercraft. Such hybrid aircraft constitutes a completely novel type of an aircraft – extremely short take off and landing on any surface (ESTOLAS). ESTOLAS aircraft will have the following major advantages compared to the existing air vehicles. This aircraft is a mixed type ""flying wing"", the basic part of which is the diskshaped centerplane. In general it serves as a receptacle of elevating gas (helium). In the channel of its center there are a jacking system and a cargo cabin and on the edges there are a pilot-passenger cabin, cantilevered wings and a tail. The combined takeoff and landing device is placed underneath: wheel and ski bearers and air cushioned landing gear. Three principles of creating the lifting force: aerostatic, aerodynamic and jet, used on this aircraft, possibility of landing on an all-terrain flat surface, airflow over the systems of control and stabilization generated by the powerplant's propellers, rather low specific loading on bearing surfaces with simultaneous use of modern aviation control systems and navigation allow to achieve high reliability and safety of operation.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Twinning towards excellence in alternative methods for toxicity assessment' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The objections to animal experiments which have accumulated on both ethical and scientific grounds drive the development of new alternative approaches which do not use animals. Despite the plethora of available alternative methods in different fields of safety assessment, there are still either no validated animal-free replacement methods for some toxicity endpoints or they need a thorough improvement/development. NIOM, as an institute from the Widening Country, aims to increase its capacity (portfolio) towards available in vitro methods for toxicity testing. TWINALT project aims to: i) significantly strengthen the research position of NIOM in the field of alternative methods to toxicity assessment by linking it with 3 prominent scientific partners in this field from Belgium (VUB), Norway (NILU), and Italy (UMIL); ii) enhance the S&T capacity of the 4 linked institutions with a principal focus on the NIOM; iii) commercialize and integrate the TWINALT research with the needs of society at the local, regional, national, European and global level.Five research areas have been identified to be focused on in TWINALT: i) modern methods for cytotoxicity assessment (High Throughput/Content Screening); ii) new cell models in alternative methods (co-cultures, 3D models); iii) standard/modern alternative methods for genotoxicity and carcinogenicity assessment; iv) characterization of cell-nanomaterial interactions under in vitro conditions; v) in silico methods in safety assessment.The work will be organized into 4 packages: i) elaboration of a common RTD and innovation strategy on alternative methods; ii) exchange of know-how with partners through training mobilities; iii) communication, exploitation and dissemination activities (web-site, regional and international events, joint
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Self-organized TiO2 nanotubes-intrinsically conductive polymer composite material for applications in solar cells, biomedicine systems, and electro-chromic devices' (NANOICP).

assistant: **Concept**

This project aims to develop new generation of composite material based on TiO2 nanotubes and intrinsically conductive polymer (ICP) deposited in nanotube framework. Our objective is to combine of electrical conductivity of ICP and UV sensitivity of TiO2. Particularly, dye sensitization of TiO2 in conjunction with ICP is of our interest. It is expected that high surface area morphology offered by high aspect ratio nanotube system, which provide extremely high TiO2/ICP interface, will play the key role in specific interaction between conductive polymer and wide band-gap semiconductor. Remarkable electric and optical properties of new composite material are expected. A variety of polymer dopants, electrochemical conditions, and electropolymerization methods will be applied in order to find electrochemical route for successful, homogeneous deposition of ICP`s in TiO2 nanotube system. Two conductive polymers will be electrosynthesized in nanotube framework: poly-3,4-ethylenedioxytiophene (PEDOT) and poly-3-hexyltiophene (P3HT). The p-n junction, which is expected at the polymer-semiconductor interface, will be electrochemically controlled by switching polymer between oxidizing and reducing state. PEDOT will be tested as a p-type electrolyte in dye sensitized solar cell device Ti/TiO2/ruthenium-based-dye/PEDOT. P3HT absorbs visible light and thus may replace the dye and the electrolyte, giving the function of charge transport and light absorption. The effects of nano-architecture of the Ti/TiO2/P3HT composite material will be studied in order to meet the dimension of phase separation within the exiton diffusion length of the polymer. Above features make the new composite material very attractive for applications including solar cells and electro-chromic devices. Furthermore,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Multinationals, Institutions and Innovation in Europe' (MASSIVE).

assistant: **Innovation**

Multinational Enterprises (MNEs) are key ‘tectonic forces’, shaping the ‘mountains’ in a far-from-flat world economic geography. In 2010, MNEs generated value added for approximately US$16 trillion accounting for more than a quarter of world GDP (UNCTAD, 2012). The progessive expansion of firms from emerging economies into multinational enterprises is unprecedented. Outflows of FDIs from developing economies reached the record level of $426 billion in 2012, corresponding to 31% of global outflows, up from 16% in 2007 (UNCTAD, 2013). However, there is no consensus in the academic literature on both the factors able to shape the long-term location decisions of MNEs and, more generally, on the ultimate impact of MNEs on their host economies. This lack of consensus reflects three fundamental gaps in the existing literature. First the omission of some fundamental determinants of MNEs investment decisions in ‘traditional’ national-level analyses. Territorial/spatial factors, MNEs heterogeneity and local institutional conditions have been often overlooked in MNEs location analyses. Second the limited attention to the broader set of impacts of MNEs in their host economies and the role of institutional factors as selective ‘filters’ for these impacts. Third the intimate inter-connection between location motives and impacts has remained unexplored in the grey areas between separate streams of literature. This research project will investigate the location strategies of MNEs and their territorial impacts addressing these three fundamental gaps in the existing literature, shedding new light on the factors shaping the economic geography of MNEs and their impacts and providing policy-makers at all levels with new tools to promote innovation, employment and economic recovery after the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Phase I/II Gene Therapy Trial of Fanconi anemia patients with a new Orphan Drug consisting of a lentiviral vector carrying the FANCA gene: A Coordinated International Action' (EUROFANCOLEN).

assistant: **Concept**

Fanconi anemia (FA) is a rare inherited syndrome characterized by the early development of bone marrow failure and increasing predisposition to cancer with age. Allogeneic hematopoietic cell transplantation (alloHCT) is the only curative therapy for hematopoietic manifestations of FA, although associated with complications arising from myeloablation, graft versus host disease and increased incidence of squamous cell carcinoma. The genetic correction of autologous hematopoietic stem cells (HSC) with lentiviral vectors constitutes a recent and safe alternative for the treatment of different genetic diseases affecting mature cells from different tissues and/or committed progenitors of the hematopoietic system. One of the key features of FA that make it a unique disease for gene therapy approaches rely on the characteristic proliferation defect that is already evident in the very primitive HSCs. Thus, a marked survival advantage would be expected from corrected HSCs, potentially allowing normalization of hematopoiesis in the absence or after mild conditioning. Difficulties in the collection of sufficient numbers of HSC from FA patients and the use of sub-optimal transduction protocols with gammaretroviral vectors limited the success of FA gene therapy trials conducted 10 years ago in the USA. Our innovative approach to develop for the first time an efficient and safe gene therapy of FA is based on two recent innovations: 1) Discovery of potent HSC mobilizers, such as plerixafor, and 2) Development of a new lentiviral vector by members of this Consortium, designed as Orphan Drug by the EC in December 2010. The principal objective of this Project is, therefore, the development of a multicentric Phase I/II gene therapy trial for FA-A patients, based on the genetic correction o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Blue Acid/Base Battery: Storage and recovery of renewable electrical energy by reversible salt water dissociation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The “Blue Acid/Base Battery” (BAoBaB), stores electrical energy using pH and salinity differences in water. The principle of BAoBaB is altering the acid-base balance by means of an excess of available electricity to obtain an acid and base from its corresponding salt solution. When electricity is needed, acid and base are recombined into their corresponding salt solution again while obtaining electrical work from the entropy and enthalpy gain. Our goal is to develop this totally new, environment-friendly, cost-competitive, scalable, water-based electrical energy storage system from TRL3 to TRL5.Our objectives are:1. to establish and extend the potential of BAoBaB to become a reliable and environmentally friendly way of storing (renewable) electricity at kWh-MWh scale for application at user premises or at substation level.2. to understand and enhance mass transfer in round-trip conversion techniques and hence to improve the energy conversion efficiencies of the BAoBaB system, aiming an efficiency >80% and >10 times higher energy density than in Pumped Hydropower Storage. 3. to validate under accepted utility use conditions an automatically operated BAoBaB system (with corresponding battery management) at a scale of 1 kW power and 7 kWh energy storage.4. To pave the road for cost competitive energy storage with attention to life-cycle cost and performance, aiming at <0.05 €/kWh/cycle.BAoBaB operates at a timescale of hours to days, and hence will enable a larger penetration degree of distributed and intermittent renewable energy sources. Not only the storage capacities are huge (kWh to MWh), resources are plentiful (salt and water) and environmental risks are minimal. Together with the location independence and non-toxic nature, penetration rate can be high within the EU
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The First In Vitro Diagnostic Device for the Early Detection of Cardiac Ischemia' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Cardiovascular diseases (CVD) are the leading cause of death/morbidity across the globe, accounting for 31% of all deaths in 2015. Early detection of ischemia (restriction in blood supply to tissues, causing oxygen shortage) is essential to prevent the progression of heart damage, but right now, we don’t have any biomarkers for the early detection of cardiac ischemia. In fact, almost 90% of the available in vitro diagnostic (IVD) methods are based on the quantification of markers of necrosis, an advanced stage of organ damage. Obviously, these methods are useless for the early detection of ischemic damage. AGLYC is an IVD device based on the rapid quantification circulating plasma Apo J-Glyc levels as a novel biomarker for the diagnosis, prognosis and risk stratification of ischemia and ischemic tissue damage. AGLYC demonstrates a 97% sensitivity in detecting the presence of cardiac ischemia; market state of the art is 39%. It also detects ischemic damage at an early and reversible phase (30 min after ischemia onset); state of the art can only detect ischemia 6 hrs after its onset when tissue damage is irreversible. We are currently at TRL6 having the competitive advantages of high sensitivity, early detection and cost effectiveness. The Global IVD market accounted for $61,103M in 2016 and is estimated to reach $84,647M by 2023, growing at a CAGR of 4.6% from 2017-2023. We have estimated a lab-based target market of >70M patients (USA+5EU) and a Point of Care (POC) target market of >36M patients (USA+5EU). Our main business model will be a sublicense model: a lab-based test will be developed and sublicensed to either a medical device company (like MedTech) or to a pharmaceutical company for the co-development and commercialization of the POC device. GlyCardial Diagnosti