RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Next generation HPC/QC in silico drug discovery platform for de novo design' under Horizon Europe.

assistant: **Concept**

ATLAS is a powerful in silico drug discovery platform leveraging the latest advances in high-performance and quantum computing. The platform is the result of decades of research by leading experts in molecular dynamics. The technology is grounded on over 100 peer-reviewed papers and two ERC grants. Our beta code has gathered important accolades like the prestigious ATOS-Joseph Fourier prize and first place at the foremost rational drug design competitionthe SAMPL challenge. ATLAS can replace costly and laborious experiments. It can even run entire drug discovery campaigns in silico, reducing cycle times and cost by at least 50%. By 2027, we will have a 35-project portfolio, and the first ATLAS-generated compound will reach the clinic. Thereafter, our objective is to generate a new candidate every 18 months. That year, our team will surpass 50 people and well expand into the US market. We aim at securing a leadership position in the nascent in-silico drug discovery market.


**Keywords:** Drug discovery,molecular dynamics,quantum physics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sustainable domestication of indigenous fruit trees - interactions between soil and biotic resources in some drylands of Southern Africa' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The general objectives of this project are the domestication of indigenous fruit trees by means of sustainable techniques and the study of their effect on soil to avoid degradation.Measurable, specific objectives are:* to assess the ecological and physiological requirements of promising indigenous species; * to assess the nutritional value of the fruits or their derivatives;* to assess the efficiency of the root system in exploiting soil resources;* to assess the dependence on mycorrhizal symbiosis for growth and drought tolerance;* to evaluate appropriate agronomic practices;* to assess the efficacy and limits of locally available organic fertilisers, like seaweed;* to evaluate the effect of the cultivation on the physical and chemical characteristics of the soils.Expected OutcomeThe work will enhance our understanding of the conditions determining plant success at different sites in semi-arid environments. Particularly important will be any information on practises regarding seeds, seedlings and planting techniques. The assessment of the relationships between mycorrhized roots and soil properties will contribute to the development of ways of avoiding erosion and land degradation. The results of such research could confirm indigenous fruit trees as an alternative and integrated farming system that reduces dependence on arable agriculture and enhances the quality of life of rural people.* Selection of promising phenotypes of Sclerocarya birrea, Strychnos spp., Ricinodendron rautanenii, Vangueria infausta, Azanza garkeana and Grewia flava.* Pedologic assessment of naturally productive fields in Botswana and Namibia; chemical, physical and mineralogical analysis of soils; investigation of wild trees (root growth, contents of mineral elements in roots and above-ground comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Methods and tools to improve software quality for multimedia products' (BESTMM) under Fourth Framework.

assistant: **Objectives**

Multimedia projects bear the complexity of software development aggravated by that of audio-visual productions. They are very difficult to manage and maintain within the bounds of quality and profitability. Furthermore, the heterogeneous human resources involved make it extremely delicate to ensure collective motivation and collaboration to a quality plan.The main issue in this experiment is the carrying through of the artistic intentions while quality, schedule and budget conditions are satisfied.THE EXPERIMENTThe aforementioned objective relies on the capacity of the production teams to manage themselves. Methods and standard practices have to be defined and the personnel has to acquire a good sense of efficiency analysis. This will be achieved through the following means :1) training to project management basics and tools,2) quality workshops for all to contribute and feel involved,3) standard practices defining the circulation of information.Hyptique will gain much from this effort since most of its profitability comes from the efficiency of its project management.The experiment is based on Cybermaman", a CD-ROM for all ages that provides fiction as well as educational material related to the Internet.Hyptique employs 14 people, 9 of them are involved in "Cybermaman".EXPECTED IMPACT AND EXPERIENCEHyptique hopes to gain much from this experiment. Most of it will come from the fact that the discussions on productivity should create an on-going dynamics around quality issues and thus tighten binds amongst employees, enhance motivation and insure that the company as a collective whole will continue to adapt to production conditions."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tunnel ionization in three-dimensional tailored light fields', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Tunneling is a non-resonant, quantum mechanical process without any classical analog. The electric field of a strong laser pulse can bend atomic and molecular potentials such that an electron can be liberated via tunneling. This allows for probing properties of atomic and molecular orbitals with subnanometer and attosecond resolution (like a tunneling microscopes tip probes properties of the investigated surface). So far, the electric field vector is restricted to a one-dimensional line (1D, e.g. linearly polarized light) or a two-dimensional plane (2D, e.g. circularly polarized light). Since tunneling acts like a filter to the same 1D or 2D subspace in position space, this limits the sensitivity to the 3D structure of the probed orbital. I propose to build an experimental setup that can synthesize 3-dimensional (3D) light fields with peak intensities of up to 1015 W/cm2. 3D light fields will significantly increase the sensitivity of strong field tunneling to the 3D properties of the bound electronic wave function. Further, non-adiabatic dynamics during tunneling and subsequent acceleration, recollision, or recapture of the electronic wave packet will be driven by the time-dependent 3D field as well. This will e.g. allow for the creation of chiral electron distributions in atoms (i.e. chiral atoms), selectively tunnel ionize one enantiomer of a racemic mixture of chiral molecules and enable a new type of pump-probe experiments. The capability to generate 3D light fields will be matched with a 3D detection system, which measures 3D electron momenta in coincidence with ionic fragments. My team and I will use this novel 3D-light-3D-detection-platform to investigate tunnel ionization from atoms, diatomic molecules, and chiral molecules. I anticipate that the proposed experi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Dark Ocean Cosmeceuticals -DOC-: The Cosmetical and Pharmaceutical Potential of Marine Dissolved Organic Matter'.

assistant: **Concept**

An ageing population as well as chronic and infectious diseases, pandemic threats and antimicrobial resistance are currently on the rise. As a consequence, increasing attention is paid to the development of novel drugs, treatments and personal care products. In this context, blue biotechnology offers an opportunity to explore the potential of the marine microbial world to produce biological active metabolites, which may support health and wellbeing. The general goal of this proposal is the extraction and identification of biologically active substances in one of the largest reservoirs of organic material on Earth: the recalcitrant marine dissolved organic matter (RDOM) pool. This pool is an unexplored potential source of bioactive substances. For this purpose, the RDOM will be extracted from (1) one of the oldest water masses of the global ocean located at intermediate depths of the North Pacific and (2) the reworked DOM of marine sediments porewater in the North Sea. A comparative screen will be performed with the more recent surface oceanic water of the North Pacific. The antioxidant, immunostimulant and antitumoral potential of these DOM samples will be explored to evaluate possible cosmetical and pharmaceutical suitability. The DOM molecular diversity and features identified by mass spectrometry and nuclear magnetic resonance will be correlated with the different modes of bioactivity. This proposal will enable Dr. Catalá to broaden her expertise on molecular characterization of the DOM pool, to learn new methodologies of bioactive substances identification as well as to meet future challenges on marine natural product research, endorsed by the H2020 Societal Challenges of 'Health, Demographic Change and Wellbeing' and 'Marine Research and the Bioeconomy'. This combi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Strain Localisation in Magma' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The tendency of geomaterials to localise deformation is a measure of “the fragility of the Earth” – a threshold to the occurrence of geological hazards. At volcanoes, the remarkable, unpredictable and alarming occurrence of eruptions, switching from low-risk effusive to high-risk explosive eruptive behaviour is a direct consequence of strain localisation in magma (SLiM).A deformation mechanism map of magma subjected to strain localisation will allow numerical models with higher accuracy, which, coupled to an understanding of the mechanics driving the monitored geophysical signals precursor to failure, will enhance eruption forecasts.We propose a truly innovative and interdisciplinary approach to a description of SLiM. This collaborative study will pioneer in the integration of efforts from field geologists, experimentalist, mineralogists, petrologists, seismologists, and numerical modellers to underline the effects of microscopic processes responsible for the large-scale impacts of strain localisation in magma during transport and eruption.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Support Utilisation of Sustainable and TAilored INnovative methods for HTA' (SUSTAIN-HTA).

assistant: **Concept**

With ever-increasing complexity of novel health technologies, Health Technology Assessment (HTA) methodologies have been evolving rapidly. However, there is now a lack of harmonization on the methodological needs of HTA bodies against the varied methodologies and tools. There is a need for a solution that allows for continuous dialogue between HTA bodies and academia, a solid, unified base for implementation of fit-for-purpose methodologies and long-term upskilling on HTA expertise. SUSTAIN-HTA aims to upskill the pan-European HTA body workforce and harmonise HTA expertise via a robust education and training framework that ensures continuous uptake of novel, need-based HTA methodologies. Aligned to the methodological developments as part of the new EU HTA regulation, the project will set up a mechanism for dialogues and interaction between HTA bodies and academia to regularly assess HTA-bodies’ needs in parallel with a methods observatory that ensures up-to-date knowledge of latest HTA methods. Prioritized methods will be piloted within HTA bodies and, after endorsement, implementation will be supported by a harmonized training and education framework that will be established to upskill the HTA experts. A long-term dissemination and communication structure among all stakeholders will be established to guarantee a feedback loop between HTA needs, methods assessment and associated training needs. Via the collaboration of 5 universities, 7 HTA bodies, 2 SMEs and one non-profit organization, SUSTAIN-HTA brings together extensive experience in (coordinating) previous European funded HTA-related projects including HTx, EHDEN, COMED and GetReEal. With this, SUSTAIN-HTA has the background for establishing sustainable business models that ensures continuity of project outcomes a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deterioration of prehistoric rock art in karstic caves by mass tourism: integrated study (environment, geology, geochemistry and microbiology) for their conservation' to be submitted under Fourth Framework.

assistant: **Abstract**

The aim of this project is to study the deterioration processes that take place in caves with rock painting following their opening, excavation and adaptation for mass tourism, and the effects of microclimate, environment, geology, geochemistry and biology on the conservation of the paintings developing the following issues: - A comprehensive database of microclimatological and environmental pollution information relevant to the deterioration of rock art caves. - A predictive deterioration of rock art caves. - A set of recommendations for cave management and conservation of rock art.Four caves have already been selected: two in the north of Spain (Altamira and Candamo), and one in the south (Tito Bustillo), together with a fourth in southern Italy (Grotta dei Cervi). These four caves cover a sufficiently broad range of variation: in time from discovery (from 175 to 25 years); type of wrok carried out to make them accessible (from the substantial changes of building walls and chambers in Altamira, to the scarce changes in the Grotta dei Cervi - with the cases of Candamo and Tito Bustillo being intermediate); impact of tourism (from several thousand visits to none); introduction of factors altering environmental conditions (from electrification and lighting, opening of new entrances, blockings off, etc., to their conservation in a practically original state); different states of deterioration of the paintings, or their varied biological colonisation. This will provide general and particular conclusions to be reached following the work plan proposed, in which the karstic geomorphology of the caves, the geochemistry - including the seasonal variations in CO2, the analysis of water from rainfall and infiltration, geochemistry of the speleothemes, crystal growth processes, co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Knowledge flows within emerging multinationals: the case of subsidiaries of Latin multinationals in Europe' (2007-2013).

assistant: **Innovation**

Firms from emerging countries are increasingly expanding their global presence by directly investing abroad and becoming multinationals on their own right. Those so-called emerging multinationals (E-MNCs) are gaining space in the global business arena, largely dominated by multinationals from the triadic countries. Studies so far have focused on the factors driving E-MNCs to engage in foreign direct investment. A central issue is whether the E-MNCs possess competitive advantages that can be exploited abroad, or if they are in fact seeking for acquiring and developing such advantages overseas. This research proposal intends to bridge a gap in the research on E-MNCs by focusing on the European subsidiaries of Latin American MNCs (LA-MNCs). It addresses the question of how multinationalisation of developing countries’ firms affects innovation and knowledge flows within them, and between them and their host economies. Our objective is to identify the patterns of knowledge flows to and from the European subsidiaries of LA-MNCs by analyzing the exchange of knowledge between them and: 1) their headquarters, and 2) host economies. The main expected outcome of this study is the understanding of to what extent the European subsidiaries of LA-MNCs: 1) send knowledge to and receive knowledge from their parent headquarters in Latin America; and 2) source in and contribute with positive spillovers to the knowledge base of their European hosts. This research proposal deals with highly complex phenomena, innovation and multinational corporations; it is interdisciplinary and multidisciplinary in essence, and integrates concepts and methods from several fields of economics and international business. The methodological approach combines different methods and sources of information. We wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Micro-economic instruments for impact assessment of multifunctional agriculture to implement the Model of European Agriculture' to be submitted under Sixth Framework.

assistant: **Abstract**

Common Agricultural Policy (CAP) reform aims at higher international trade compatibility and better targeting of social, environmental and consumer concerns to ensure the sustainable development of EU agriculture. To optimise the effectiveness and efficiency of CAP reform options towards multifunctionality implementations, tools are required to assess agricultural impacts on the multiple functions of European landscapes. The EU's Model of European Agriculture (MEA) has a multifunctional perspective but policy makers lack multifunctionality impact assessment tools. The proposed project develops such a tool, MEA-Scope, that will close the gap between pure ecological or social process models and sectoral macro-econometric or equilibrium models. To ensure compatibility with the MEA, an MEA-specific interpretation of multifunctionality will be devised. MEA-Scope will be spatially explicit and will perform impact assessments of agricultural land use at two scales: farm and landscape. This will be achieved by link three existing micro-economic models that simulate different aspects of farm structure, economics and environmental impact, so enabling joint- production to be predicted. Appropriate scope and detail will be ensured by simultaneous analyses of the regional demands for multiple landscape functions and of end user information needs. MEA-Scope will describe, analyse and evaluate the multifunctionality of agricultural production under a multitude of environmental, social and economic conditions. MEA-Scope will here be applied to one exemplary farming system (beef production) for 8 European landscapes including both, agriculturally benign and marginal land in accession countries and EU member states. Beef production is chosen because it is among the most adaptable systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The arrival of Homo sapiens in northwestern Europe: a multi-proxy investigation of regional diversity in the Lincombian-Ranisian-Jerzmanowician (LRJ)' in the context of a Horizon Europe call.

assistant: **Objectives**

In 1826, the first LRJ blade point in Britain was found at Kent’s Cavern. ARRIVAL will return to the cave 200 years later to answer the fundamental questions we still ask about these tools - who made them and when? Ground-breaking advances in archaeological science methods over the past decade enable us to study the dynamics of the Neanderthal-Homo sapiens transition in unprecedented resolution but few sites have been explored with the full suite of methods. New findings from Ranis, Germany, have recently proven that Homo sapiens were present in northern Europe between 47,500 - 43,000 years ago, much earlier than previously suspected. These people made stone tools known as the Lincombian-Ranisian-Jerzmanowician (or LRJ), which are found at more than 40 sites across northern Europe and were previously thought to have been made by Neanderthals. Only one high-resolution dataset (Ranis) exists for the LRJ. The lack of additional datasets prevents us from investigating variations between LRJ occupations. ARRIVAL will bring together an international, interdisciplinary team to investigate key LRJ sites using a multi-proxy approach, combining new excavations, chronometric dating, non-destructive collagen screening, palaeoproteomics, isotopic and aDNA analysis with traditional lithic and palaeoecological analysis. ARRIVAL will focus on newly excavated material to produce robust new datasets whilst providing better contextualisation for legacy collections. New methods will be developed to improve the accuracy and reliability of 14C dating in this crucial time-period, enabling us to produce the first robust chronological framework for the LRJ. ARRIVAL will determine if the LRJ can now be considered a reliable proxy for Homo sapiens across its entire range and provide the first hig