RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Breaking down the wall between human health and environmental testing of endocrine disrupters: EndocRine Guideline Optimisation' (ERGO), addressing dissemination and exploitation.

assistant: **Impact**

ERGO presents a new approach that will support a paradigm shift in the regulatory use of standardized test guidelines (TGs) by breaking the existing wall between mammalian and non-mammalian vertebrate testing and assessment of endocrine disrupting chemicals (EDCs). The highly conserved thyroid system will be used as the “proof of concept”, but also other conserved endocrine axes/systems such as the Retinoid X Receptor (RXR) and the Hypothalamus Pituitary Gonadal (HPG) axis can be adapted to the cross-vertebrate class approach. ERGO will investigate a battery of draft in vitro assays and evaluate thyroid-responsive biomarkers and endpoints (B/E) suitable for extrapolation of effects from fish and amphibian tests to humans and other mammals (and vice versa) and finally validate successful B/E for inclusion in existing in vivo or new in vitro OECD TGs. A cross-class adverse outcome pathway (AOP) network will provide the scientifically plausible and evidence-based foundation for the selection of B/E in lower vertebrate assays predictive of human health outcomes. In silico modeling and biotransformation data will support cross-vertebrate class effect extrapolation. Major outcomes of ERGO will be: 1) New thyroid-related B/E for inclusion in OECD TGs for improved identification of TDC. 2) An Integrated Approach to Testing and Assessment (IATA) of chemicals for TD based on a multi-class vertebrate AOP network connecting endocrine mechanisms in one vertebrate class to adverse outcomes in another class for safer regulation of EDCs. 3) A tool for TG end users, such as regulators and industry, to extrapolate thyroid effects between vertebrate classes. Implementation of the ERGO IATA strategy in regulations of EDC will make hazard and risk assessment faster, cheaper, simpler and saf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Comparative signature of Marburg virus cell activation as a blueprint for the identification of antiviral targets against newly emerging viruses' to be submitted under Horizon Europe.

assistant: **Abstract**

Identifying cellular attachment factors and functional receptors plays a critical part in developing an understanding of a newly emerging virus. However, the identification and therapeutic targeting of plasma membrane proteins critical for virus infection is often difficult due to the transient nature of virus-cell binding and the overall kinetics of the infection process. Our goal is to interrogate virus-host cell interaction and cellular uptake of Marburg virus (MARV), a highly pathogenic and clinically relevant member of the filovirus family. To specifically target virus-plasma membrane interaction we will use a unifying inverted infection platform that allows us to halt and synchronize virus infection at the cell binding stage. Our approach is compatible with BSL-4 environment and multi-Omics technologies. It will allow us to identify the signature of virus-host cell activation, i.e., proteins involved in virus-cell entry in a tissue-specific manner. This screen will be complemented by an innovative combination of proteomics, virus-host cell interaction analysis and imaging approaches to pinpoint and characterize the involved cellular and viral proteins, their post-translational modifications and how they mechanistically concert in viral uptake. Our unique combination of different technologies will lead to the identification of viral and cellular interaction partners which will in parallel be specifically targeted by high-throughput compound screening to identify small molecules that inhibit virus-receptor interaction. Moreover, we will use our gained knowledge of tissue-specific post-translational modifications to develop improved vaccine candidates as additional prophylactic countermeasures against MARV. Our project will further deliver a blueprint experimental pi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Deciphering the function(s) of the C-type lectin DCIR/CLEC4A in tuberculosis'.

assistant: **Objectives**

Tuberculosis (TB), caused by the infectious agent Mycobacterium tuberculosis (Mtb), is a devastating disease and one of the leading causes of death in the developing world. Dendritic cells (DCs) play a key role in anti-mycobacterial immunity and express a range of pattern-recognition receptors which are involved in the recognition of Mtb antigens. Dr Olivier Neyrolles’ lab has characterised a number of these receptors, with the most recent being, and the focus of this project, the Dendritic Cell Immunoreceptor (DCIR). They have demonstrated that compared to wild-type mice, mice with a knockout in the DCIR homolog (mDCIR1) display increased antimycobacterial immunity as a result of an impaired response to type I interferon and an increased production of IL-12 in DCs. Consequently, mDCIR1-KO mice control Mtb better than their wild-type counterparts, but also develop increased lung inflammation. Based on these findings, it is hypothesised that DCIR is a key regulator of the balance between type I and type II interferon responses. The aim of this project is to implement a multidisciplinary strategy to investigate i) expression and function, ii) signalling, and iii) trafficking of DCIR in the context of Mtb infection. These studies will be focused on the aforementioned mDcir1 in addition to a second murine DCIR homolog mDCIR2, to evaluate the extent to which they play redundant or complementary roles in Mtb immunity. This will be accomplished using i) mDcir1- and mDcir2- KO mice to assess bacterial burden and the subsequent inflammatory response, ii) large-scale phosphoproteomics and transcriptomics to assess signalling events associated with DCIR-ligand binding, and iii) immunoelectron and immunofluorescence microscopy to examine the trafficking of the DCIR-ligand complex.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Long Lasting Reinforced Concrete for Energy Infrastructure under Severe Operating Conditions' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The main goal of the LORCENIS project is to develop long reinforced concrete for energy infrastructures with lifetime extended up to a 100% under extreme operating conditions.  The concept is based on an optimal combination of novel technologies involving customized methodologies for cost-efficient operation. 4 scenarios of severe operating conditions are considered:1. Concrete infrastructure in deep sea, arctic and subarctic zones: Offshore windmills, gravity based structures, bridge piles and harbours2. Concrete and mortar under mechanical fatigue in offshore windmills and sea structures3. Concrete structures in concentrated solar power plants exposed to high temperature thermal fatigue4. Concrete cooling towers subjected to acid attackThe goal will be realized through the development of multifunctional strategies integrated in concrete formulations and advanced stable bulk concretes from optimized binder technologies.  A multi-scale show case will be realized towards service-life prediction of reinforced concretes in extreme environments to link several model approaches and launch innovation for new software tools.The durability of sustainable advanced reinforced concrete structures developed will be proven and validated within LORCENIS under severe operating conditions based on the TRL scale, starting from a proof of concept (TRL 3) to technology validation (TRL 5).LORCENIS is a well-balanced consortium of multidisciplinary experts from 9 universities and research institutes and 7 industries whose 2 are SMEs from 8 countries who will contribute to training by exchange of personnel and joint actions with other European projects and increase the competitiveness and sustainability of European industry by bringing innovative materials and new methods closer to the marke
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The advanced eco-technology manufacturing of materials as a way of competitiveness for Europe's industrial business' (FELTWOOD) targeting Horizon 2020.

assistant: **Abstract**

EU furniture industry is facing enormous competition from countries having low production costs. China is now the largest furniture exporter to the EU, accounting already for over half of total furniture imports to the EU  and growing rapidly.To avoid this, and keep added value, turnover, earnings and employment in Europe, production costs must be more competitive to continue producing high-quality furniture at competitive prices. Access to sourced raw materials, the cost and complications of harvesting wood in the EU affect all segments of the value chain of the furniture sector. Fluctuations in raw material prices and problems relating to availability of products respecting environmental, sustainability and technical standards and regulations are factors upstream the value chain that negatively impact furniture production.An innovative ecological materials and industrial company, Feltwood Ecomateriales, S.L., has developed the world´s first production technology able to get 100% vegetal fibre industrial raw material from agricultural organic waste and use it to produce panels for furniture industry. This novel material is a real alternative for wood-based panels used by furniture manufacturers nowadays. It is cheaper than wood, not subject to EU wood related directives and does not use any adhesive like wood-based panels.Feltwood´s initial commercialisation plan is based on four pillars: product, price, promotion and target countries (Spain, Portugal, France, Germany and Italy). The amount of European furniture companies belonging to our target markets are 67,000 Italian, 14,000 Spanish, 52,000 German, 38,000 French and 2,072 Portuguese. This planning will be executed in collaboration with our key-stakeholders, knowing that Feltwood has protected it through an industr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Machine Learning of Speech Recognition Models for Controller Assistance' in the context of a Horizon 2020 call.

assistant: **Objectives**

One of the main causes hampering the introduction of higher levels of automation in the Air Traffic Management (ATM) world is the intensive use of spoken language as the natural way of communication. Data link will be another media of communication with its known advantages compared to voice communication but for the future it is still assumed that data link communication will increase but never fully replace voice communication. Particularly for the time being controllers and pilots exchange information by spoken language, whereas automated systems understand the situation based only on sensor information. This difference in the end creates misunderstandings between operators and systems which lead to failures and further on to a lack of acceptance for automation. One promising solution is the introduction of automatic speech recognition as an integral part of automation.Recently, the venture capital funded project AcListant® has achieved command error rates below 2% based on Assistant Based Speech Recognition (ABSR), developed by Saarland University (USAAR) and DLR. ABSR combines speech recognition with an assistant system, which generates context information to reduce the search space of the speech recognizer.One main issue to transfer ABSR from the laboratory to the ops-rooms is its costs of deployment. Each ABSR model must manual adapted to the local environment due to e.g. different accents and deviations from standard phraseology. This project proposes a general, cheap and effective solution to automate this re-learning, adaptation and customisation process to new environments, taking advantage of the large amount of speech data available in the ATM world. Machine learning algorithms using these data sources will automatically adapt the ABSR models to the respect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Insights into folding and function of RET by structure determination' in the context of a Sixth Framework call.

assistant: **Objectives**

This proposal describes a structural biology research project aimed at determination of the three-dimensional structure of the extracellular domain of RET. RET is a unique member of the family of receptor tyrosine kinases. Its biological function is to med iate signalling by members of the GDNF family of neurotrophic factor across the plasma membrane. GDNF signalling through RET is crucial for survival of dopaminergic neurons in the substantia nigra. These neurons are progressively lost in Parkinson¿s diseas e. RET and GDNF are therefore important proteins in the search for treatments of Parkinson's disease. Signalling through RET is impaired in the congenital human disease Hirschsprung¿s disease, where point mutations in RET induce misfolding and prevents RET from reaching the membrane. Contrarily, mutations found in various parts of the ret gene lead to oncogenic transformation. Mutations found in the extracellular domain of RET cause a cancer known as multiple endocrine neoplasia 2A (MEN2A). To allow mechani stic analysis of the modus operandi of RET in both loss- and gain-of-function variants, we will determine the structure of extracellular domain of RET using x-ray crystallography. In addition to understanding the RET protein architecture, we will produce R ET mutant variants, which are misfolded in patients with Hirschsprung¿s disease, but which can be produced recombinantly in a functional state. A direct comparison of wild-type RET with a folding-rescued RET mutant involved in HSCR will the address the que stion whether major structural changes are induced in the RET structure by the mutations found in Hirschsprung¿s disease. Taken together, this proposal constitutes a natural extension of the research interest of the applicant and will provide cutting-edge inf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Islam, citizenship and the dynamics of european integration'.

assistant: **Concept**

The project focuses on the role played by religious identities in the dynamics of European integration. It analyzes how Islam acts both as an obstacle to European integration, and as a resource for the political and cultural integration of migrants into European societies. The project will bring together 10 scholars from 7 countries. These scholars do research on Muslim communities in their respective countries, and have multidisciplinary backgrounds. Together they will create a theoretical and methodological framework for analyzing Islam in Europe, which, in turn, will enable the juxtaposition of national empirical data on immigration, ethnicity, and religion. They will exchange views during 2 collective meeting and a comparative symposium on religion and European governance. Their analyses will be diffused -via publishing and the creating of a web site- to academic circles, as well as to policymakers and Muslim communities in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Fundaments and Principles for Measurement and Characterization of 21st Century Science and Engineering Surfaces', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This proposed project explores fundaments and principles for surface measurement and characterization for ultra/nano-precision non-Euclidean geometry and deterministic surfaces, which are vital for making possible key areas of 21st century science - pure and applied, engineering and bio-engineering.  The research will explore an original integrated measurement and characterization system with two major aspects: (1) Characterization: to develop radical new thinking as to what are the fundamental building blocks of a texture-characterization system and apply that thinking to non-Euclidean and deterministic surfaces. It will explore necessary and sufficient mathematical operations and principles, surface decomposition models, distortion-free representation of texture etc. (2) Measurement: to investigate principles and enabling optical methods to on-line/in-line measurement for ultra/nano-precision non-Euclidean geometry and deterministic surfaces.  The fruits of this research project will significantly facilitate surface-manufacturing control and functional performance of surfaces applied in 21st Century Science and Engineering over a wide set of sectors. Examples are surfaces used in optics and target shells in high-power laser-energy systems, optics in new earth/space-based large telescopes (e.g. the 42 m E-ELT telescope), interfaces in fluid-dynamics (energy-efficient jet engines, aircraft fuselages and wings), long-life human-joint implants, microelectronics and MEMS/NEMS devices in nanotechnology applications.  The capability to perform surface quantitative measurements and characterization on the above key components does not exist today. This confronts the state-of-the-art in surface-measurement science with regard to new surface characteristics (structured or patte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Investigations on the nature of junctional complexes in the vertebrate ovarion follicle'.

assistant: **Objectives**

Cell-cell interaction, and particularly cell-cell adhesion and gap junctional communication, appear to play an important role during embryo development and tissue formation. In addition, at least in the case of desmosomal- and caherin-based cell adhesion, these processes may have a decisive role in the formation of carcinomas, tumors and metastases. Both in mammals and lower vertebrates, desmosomal structures and gap junctions have been described in close proximity in the ovarian follicle, although their molecular composition and specific physiological role during follicle development remains to be elucidated. Recent experiments using specific molecular approaches have sugested that cell adhesion may require signaling trough gap junctional pathways, and thus both cell contact structures appear to be interdependent. The aim of the present project is to develop new information on the molecular composition and specific cellular localization of the desmosomal proteins in the vertebrate ovarian follicle. In addition, as a novel approach, the specific interactions between desmosomal and gap junctions, and their possible significance during follicle development, will be investigated using specific antisera and transfection of cDNAs encoding stable dominant-negative inhibitors.