RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Liquid-Liquid Phase Separation and Translational Control  in the developing cortex and its implications for Neurodevelopmental Disorders.' (Neuro-Phase) targeting Horizon Europe.

assistant: **Abstract**

Neurodevelopmental disorders (NDDs), including Fragile X Syndrome (FXS), are a heterogeneous group of conditions leading to difficulties with speech, learning and other neurological functions greatly affecting patients and healthcare, societal, and educational systems. The rising prevalence of NDDs highlights the urgent need to understand their origins, often rooted in early cortical development. In humans, the cerebral cortex, responsible for cognitive functions like language and learning, is susceptible to disruptions during early brain development, a process tightly regulated by neuronal growth and protein synthesis. The coordination of biochemical events in eukaryotic cells, including protein synthesis, is facilitated by compartmentalizing key molecules either into organelles or as membraneless condensates via liquid-liquid phase separation (LLPS). LLPS is crucial for neurotransmission, memory, and synaptic plasticity. The fragile X messenger ribonucleoprotein 1 (FMRP) has been shown to undergo LLPS with the translation factor 4E-BP2 (eukaryotic initiation factor 4E binding protein 2), a key regulator in the mechanistic target of rapamycin (mTOR) signaling pathway implicated in both autism and FXS and the development of cortical outer radial glia. The Neuro-Phase project will investigate the role of LLPS and the molecular and cellular mechanisms involved in NDDs and more specifically the role of 4E-BP2-FMRP LLPS interaction in translational control and early human brain development which has yet to be explored. To test this hypothesis, the Neuro-Phase project will use innovative biological models, including human induced pluripotent stem cell-derived brain organoids and organotypic cultures of post-mortem human embryonic cortical explants. This project will provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Poplars - a multiple-use crop for European arable farmers', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

In a time of European food surpluses, problems of rural unemployment and crises in certain sectors of the agricultural industry, it is increasingly important that economically viable non-food crops are found to assist in the diversification of the agriculture. CAP reforms proposed under Agenda 2000 are likely to result in a much reduced area of 'set-aside' land, and the utilisation of much of this in the production of alternative crops will prevent a return to the huge agricultural surpluses of the 1980's.  Poplars probably offer one of the best opportunities to produce a crop that can be economically viable, whilst having generally positive effects on the environment - another important criterion. The recent EC-funded Poplar for Farmers project has confirmed this potential, but the bio-economic models developed within that project require further testing. That project also focused principally on countries that already have established poplar industries, such as Belgium, Italy and France. The new project proposed here will expand into areas with less well developed poplar growing expertise (whilst retaining specialist expertise from Belgium) and will include countries to the north and east, with large areas of farmland that might be exploited. The work on identification of suitable areas undertaken by Poplars for Farmers will be greatly developed using geographical information systems. There are, of course, some objections to the expansion of poplar production. Generally these objections are founded on concerns about the impacts on landscapes and on water resources. These aspects, and the impact of poplar on biodiversity, will be objectively researched by the PAMUCEAF project.  Markets for poplars are numerous and the flexibility of the crop means that there is a vast a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MEDiterranean Sea Acidification in a changing climate' (MEDSEA).

assistant: **Innovation**

Increases of atmospheric CO2 and associated decreases in seawater pH and carbonate ion concentration this century and beyond are likely to have wide impacts on marine ecosystems including those of the Mediterranean Sea. Consequences of this process, ocean acidification, threaten the health of the Mediterranean, adding to other anthropogenic pressures, including those from climate change. Yet in comparison to other areas of the world ocean, there has been no concerted effort to study Mediterranean acidification, which is fundamental to the social and economic conditions of more than 130 million people living along its coastlines and another 175 million who visit the region each year.The MedSeA project addresses ecologic and economic impacts from the combined influences of anthropogenic acidification and warming, while accounting for the unique characteristics of this key region. MedSeA will forecast chemical, climatic, ecological-biological, and socio-economical changes of the Mediterranean driven by increases in CO2 and other greenhouse gases, while focusing on the combined impacts of acidification and warming on marine shell and skeletal building, productivity, and food webs. We will use an interdisciplinary approach involving biologists, earth scientists, and economists, through observations, experiments, and modelling. These experts will provide science-based projections of Mediterranean acidification under the influence of climate change as well as associated economic impacts. Projections will be based on new observations of chemical conditions as well as new observational and experimental data on the responses of key organisms and ecosystems to acidification and warming, which will be fed into existing ocean models that have been improved to account for the Mediter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'p53 control of epithelial homeostasis' under Seventh Framework.

assistant: **Concept**

Background: Our recent studies implicate p53 in gut tissue homeostasis - suppressing epithelial invasion. This function is tightly linked to suppression of a gene cluster (PSIS- p53-Suppressed Invasiveness Signature), which requires Wnt activation and other cues, yet is only expressed upon loss of p53. The invasive signature explains a broad spectrum of the invasiveness property, from the loss of enterocyte polarity to matrix degradation, pointing to a concerted action. We documented a tight association between invasiveness and coexpression of several PSIS genes in different mouse models and showed that PSIS expression is essential in mediating epithelial cell invasiveness following p53 depletion.Goal: Elucidate functions of p53 activation which are of particular importance for epithelial tissues. Understand how WT p53 contributes to preserving epithelial boundaries, prohibiting invasion and abnormal cell mixture and controlling stem cell dynamics under tissue stress.Methodology: We will investigate the epithelial role of p53 and the invasive signature genes in several mouse models of inflammatory bowel diseases and intestinal cancer. These models will incorporate p53-modulating switchable genetic elements and cell-tracking genetic markers for monitoring tissue dynamics. Analyses of relevant human pathology samples will complement the mouse studies.Significance: Invasion is a defining hallmark of malignancy and understanding early invasion of tumor cells is of fundamental importance in designing future therapies for cancer - targeting PSIS is an example. PSIS database may also be used to develop biomarkers for distinguishing malignant tumors from benign ones, a critical determinant of therapeutic options in several types of cancers, currently solely based on morphologic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Understanding the Biology of Human Enteroendocrine Cells' to be submitted under Horizon 2020.

assistant: **Abstract**

Intestinal epithelium consists of self-renewing crypt-villus units and contains 6 mature cell types: Enterocytes, goblet cells, Paneth cells, Tuft cells, M cells and Enteroendocrine cells (EECs). The rare EECs are subclassified by the (>20) hormones they produce. Generally, EECs sense intestinal content and regulate gastrointestinal activity, systemic metabolism and food intake. While one EEC hormone, GLP1, has been developed into a highly successful diabetes drug, a paucity of laboratory models has complicated human EEC studies. Previously, we identified adult crypt stem cells by the novel marker Lgr5, and established conditions to grow ‘gut organoids’ from these. By single cell RNA sequencing, we have resolved the complex EEC subtype hierarchy into 5 lineages. Our studies underscore significant differences between mouse and man, not unexpected given the divergent diets and metabolism. Gut organoids can be manipulated to contain all EEC lineages. We have created a set of human organoids in which the individual hormones are fluorescently tagged by CRISPR. The current proposal exploits the technologies described above, as well as our ‘Human EEC Atlas’ to generate a detailed picture of the biology of EECs, their triggers, their interconnectivity and their products. To this end, I propose to:1.Complete the Human EEC Atlas and hormone-tagged organoid set for stomach and colon. 2.Resolve how individual EEC subtype fates are set. 3.Resolve which luminal receptors and ligands allow sensing of nutrient components and microbial products4.Resolve cross-regulation of EEC subtypes.5.Investigate systemic effects of novel EEC products in mouse knockout models.Successful completion of this proposal will generate a comprehensive characterisation of EECs. This will inspire new therapeut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Blending Realities for Interaction across Distributed Group Environments' (BRIDGE).

assistant: **Innovation**

Creative problem-solving in face-to-face collaboration relies on spatiality, which is lacking in current distributed collaboration tools. What if distributed groups could blend their physical spaces to collaborate as if they were face-to-face? Mixed Reality (MR) offers this potential by arranging collaborators’ avatars around shared physical surfaces like desks and whiteboards. Proxemics theory highlights that this spatial arrangement makes collaboration effective. But when distributed space arrangements are dissimilar, it causes spatial incongruencies in collaboration cues, such as pointing gestures.To address this challenge, BRIDGE will develop a novel approach to distributed MR collaboration – Blended Proxemics – that blends people’s real physical surface interactions into a dynamic environment for group collaboration. By supporting MR users in adapting the mapping between surfaces, solutions will be able to scale beyond two users across similar spaces, to groups across dissimilar spaces. Additionally, BRIDGE will address a timely paradox: despite the hype on MR collaboration, we still have no lived experience with how it might change distributed collaboration practices. BRIDGE will establish a novel MR Living Lab to validate the effectiveness of solutions against real work environments with stakeholders. Achieving the goals of BRIDGE requires taking the risk to change both the conceptual, technical, and methodological foundations of the field. Therefore, BRIDGE will (1) develop Blended Proxemics as a new theory for spatial congruency in blended collaboration, providing a taxonomy for researchers to explore solutions, (2) invent new adaptive space mapping techniques and validate their effectiveness for group creativity, and (3) identify real-world barriers to collabo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Knowledge Based Framework for Extended Textile Circulation​' (2021-2027).

assistant: **Concept**

The tExtended project will achieve its overall objective of reduction of textile waste by 80% by within industrial-urbal symbiosis developing and demonstrating effective textile recovery, waste valorisation and recycling processes combined with digital tools, sensing systems and data-driven solutions to support sustainable circularity of textiles. We will develop a knowledge-based Blueprint, i.e. a master plan for a sustainable textile ecosystem. The basis of the Blueprint is a Conceptual Framework which determines the optimized utilization of textile flows, aiming for retention of value of materials in a safe and sustainable way. Based on the Blueprint, we will implement a real scale demonstrator, verifying its replicability and potential to reduce textile waste. tExtended brings together a multidisciplinary group of experts with complementary skills needed for twin transition in sustainable textile sector. Different types of organizations, research, industry, and non-profit organizations such as NGOs and municipal waste management are included.  The consortium consists of actors with different roles in the textile recycling ecosystem: waste management, recycling, textile materials and textile products manufacturing. Participation of forerunner companies and actors involved in textile recycling enables us also to spread best practises for textile recovery and recycling around Europe and across the sector.


**Keywords:** industrial-urban symbiosis, real scale demonstrator, textile recycling, waste valorisation, textile waste recovery, digital tools, sensing systems, data-driven solution, social innovation spin-off
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Robotic subsea exploration technologies', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

There is a need to develop an autonomous, reliable, cost effective technology to map vast terrains, in terms of mineral and raw material contents which will aid in reducing the cost of mineral exploration, currently performed by ROVs and dedicated SSVs and crew. Furthermore there is a need to identify, in an efficient and non-intrusive manner (minimum impact to the environment), the most rich mineral sites. This technology will aid the seabed mining industry, reduce the cost of exploration and especially the detailed identification of the raw materials contained in a mining sites and enable targeted mining only of the richest resources existing. The ROBUST proposal aims to tackle the aforementioned issue by developing sea bed in situ material identification through the fusion of two technologies, namely laser-based in-situ element-analyzing capability merged with underwater AUV (Autonomous Underwater Vehicle) technologies for sea bed 3D mapping. This will enable resource identification done by robotic control enabled by the synergy between AUV hovering and manipulator capabilities. The underwater robotic laser process is the Laser Induced Breakdown Spectroscopy (LIBS), used for identification of materials on the sea bed. The AUV Robotic vehicle will dive, identify the resources that are targeted for LIBS scanning through 3D real time mapping of the terrain (hydro-acoustically, laser scanners, photogrammetry) and position the LIBS in the required locations of mineral deposits on the ocean floor to autonomously perform qualitative and quantitative analyses.


**Keywords:** Multihull AUV, 3D seabed mapping, volume measurement, sea bed target identification, LIBS, Laser Induced breakdown Spectroscopy, sea bed mining exploration technologies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Skin microbial metabolites and antimicrobial peptides at the interface of skin-gut inflammation'.

assistant: **Concept**

Skin diseases affect 900 million people worldwide. Despite major efforts gaining insights in the disease mechanisms underlying Atopic Dermatitis (AD), the most common inflammatory skin disease (ISD), an effective treatment is currently lacking. AD is accompanied by skin and gut microbiota dysbiosis, suggesting an uncharacterized interplay between skin and gut. Furthermore, antimicrobial peptides (AMPs) that limit growth of bacteria in the host, were found deregulated in ISDs and Inflammatory Bowel Disease. Most of the host-microbe interactions are mediated by microbial metabolites that can spread and affect distant organs. INTERACT will investigate how skin microbial metabolites influence skin and gut inflammation through innovative research at two world leading research Universities, the Medical University of Vienna, Austria and University of California San Diego, USA under the supervision of Profs. Erwin Wagner and Richard Gallo, respectively.Recent results from the applicant demonstrated gut alterations with neutrophilic infiltration and increased fecal AMPs in a genetically engineered mouse model (GEMM) of AD generated in E. Wagner’s laboratory. Hence, this study will test the hypothesis that skin-derived microbial metabolites promote skin-gut inflammation inducing AMP expression and neutrophil recruitment. Using state of the art technologies, such as metabolomics and novel GEMMs, as well as patient-derived material, this project will determine the therapeutic and biomarker potential of microbial metabolites, which will have profound implications for ISD.The experimental approach combines the applicant’s expertise in host-microbe interactions with E. Wagner´s competence in mouse genetics and inflammatory diseases, as well as R. Gallo´s knowledge of AMPs and skin mic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Rewiring photorespiration using natural and synthetic pathways to sustainably increase crop yield'.

assistant: **Objectives**

Photorespiration – recycling Rubisco’s oxygenation production, 2-phosphoglycolate (2PG), back to the Calvin Cycle – is an ineluctable process in today’s plants, which dissipates energy and releases CO2. Photorespiration reduces CO2 assimilation efficiency, and thus biomass yield, by ~30% and represents a prime target for improving agricultural productivity, as was demonstrated in several recent studies. Yet, the engineering of alternative photorespiration routes to date is restricted to pathways that release CO2, leaving space of considerable further improvement. Another opportunity to reduce the inefficiencies of photorespiration is to minimize it by engineering C4 metabolism, which serves as a carbon-pump that increases the CO2 concentrations near Rubisco. GAIN4CROPS aims to boost plant productivity using novel strategies to minimize the inefficiencies of photorespiration. GAIN4CROPS will follow a stepwise approach, starting by engineering naturally occurring carbon pumps and culminating with the introduction of highly efficient synthetic metabolic pathways that can dramatically boost carbon fixation. First, we will engineer a C3 crop to operate the naturally-occurring C3-C4 carbon-pump, boosting carbon fixation while requiring less complex anatomical modifications than C4 metabolism and using solely genome editing and wide crosses. This step serves as a conceptually novel, ‘natural’ approach towards engineering C4 metabolism. Second, GAIN4CROPS will develop more efficient synthetic C3-C4 carbon pump variants that are based on the effective intercellular transport of aspartate or malate while conserving cellular resources. Finally, based on C3-C4 metabolism, GAIN4CROPS will explore two innovative photorespiration bypass routes which, rather than releasing CO2, fix ino