RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Amplification of human myogenic stem cells in clinical conditions' (MYOAMP).

assistant: **Innovation**

The aim of this network is to synergize expertises from European basic researchers, leaders in their field, and European SMEs specialized in stem cell amplification and in safety of these procedures, to set up conditions for autologous transfer of human stem cells in GMP conditions for the treatment of DMD by exon-skipping. Cell therapy trials in DMD has never fulfilled the promises raised by the early results obtained in mouse models. Several groups have recently demonstrated the possibility of generating a truncated, but functional dystrophin using exon-skipping, by masking splicing sequences with oligonucleotides introduced by either direct or viral transfer.The direct approach can be used as many times as needed, but is extremely expensive, while the AAV approach allows a large dissemination of the masking sequences, but triggers an immune response to the vector, and therefore can be used only once. Cell therapy can thus be used to target sites which have not been cured by the AAV approach, using autologous cells as vectors which, by fusing with the regenerating fibres of the patient, will bring a functional dystrophin to these fibres.Myoblasts become progressively exhausted in DMD patients as the disease progresses, while stem cells, such as mesoangioblasts or AC133+, remain intact and functional. However, little is known either about the possibility to transduce these cells with oligonucleotides or vectors for exon-skipping, or the methods that can be used to expand these cells in GMP conditions. The technical and ethical guidelines resulting from this network will enable SMEs to expand stem cells with myogenic potential in GMP conditions for clinical trials in patients with DMD or other neuromuscular diseases. This network is a natural link between MYORES, an exi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Impact of mitochondrial respiration efficiency on plant cell metabolism'.

assistant: **Concept**

Respiration plays a key role in the survival of aerobic organisms since it is providing ATP, the energy for the whole cell. The reactions leading to the synthesis of ATP are well known but the mechanisms by which mitochondrial respiration controls cellular functions is unknown, mainly because most mutants in respiratory enzymes are lethal. Two hypotheses have been formulated to explain how respiration activity affects the metabolism. As the product of respiration is ATP, the respiration rate has an impact on the ATP/ADP ratio and on the activity of enzymes using ATP. This control of enzyme activity by the ATP/ADP ratio is known as the adenylate control. Besides, the mitochondrial electron transfer chain (ETC) is producing reactive oxygen species (ROS) when electrons are lost during their transfer through the ETC. As ROS accumulation causes a modification of the redox status and triggers the reorganisation of cellular activity, therefore the influence of ETC activity on cellular metabolism via ROS signalling is another possibility. In plants, most of the mutants with impaired respiration are affected in complex I, the first enzyme of the ETC. These mutants have reduced ATP synthesis and enhanced stress tolerance, indicating that both the adenylate control and the ROS signalling are affected. This project aims to understand how respiration contributes to the control of plant metabolism. Several complex I mutants which possess different levels of remaining complex I activity are available in Arabidopsis. The production of ATP and ROS by the ETC will be investigated to characterise the respiratory defect caused by the reduction in complex I function. System biology approaches including transcriptomic and metabolomic will be use to highlight the mitochondrial signals causing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'BIO-Based pESTicides production for sustainable agriculture management plan' to be submitted under Horizon 2020.

assistant: **Abstract**

The BIOBESTicide project will validate and demonstrate the production of an effective and cost-efficient biopesticide. The demonstration will be based on an innovative bio-based value chain starting from the valorisation of sustainable biomasses, i.e. beet pulp and sugar molasses  and will exploit the properties of the oomycete Pythium oligandrum strain I-5180 to increase natural plant defenses, to produce an highly effective and eco-friendly biopesticide solution for vine plants protection. GREENCELL, the project coordinator, has developed, at laboratory level (TRL4), an effective method to biocontrol one of the major causes of worldwide vineyards destruction, the Grapevine Trunk Diseases (GTDs). The protection system is based on the oomycete Pythium oligandrum strain I-5180 that, at applied at optimal time and concentration, colonises the root of vines and stimulates the natural plant defences against GTDs, providing a protection that ranges between 40% and 60%. BIOBESTicide project will respond to the increasing demands for innovative solutions for crop protection agents, transferring the technology to a DEMO Plant able to produce more than 10 T of a high-quality oomycete-based biopesticide product per year (TRL7). The BIOBESTicide project will validate the efficiency of the formulated product on vineyards of different geographical areas.To assure the safety of products under both health and environmental points of view, a full and complete approval dossier for Pythium oligandrum strain I-5180 will be submitted in all the European countries. A Life Cycle Sustainability Assessment (LCSA) will be conducted to assess the environmental, economic and social impacts of the developed products.The adoption of the effective and cost-efficient biopesticide will have significan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Developing the entrepreneurial skills of farmers', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

This project will examine the economic social and cultural factors hindering or stimulating the development of entrepreneurial skills of farmers. The primary concern of the project is to recommend ways how conditions of the social, economic, political and cultural framework can be changed in order to facilitate the adoption of entrepreneurial skills for farmers and how farmers themselves can improve their entrepreneurial skills.The guiding idea comprises the persuasion that the kind of necessary entrepreneurial skills is strongly dependent on the strategic orientation of the farm. Besides recommendations a diagnostic tool will be elaborated with which farmers can be positioned according to their entrepreneurial strategy and their entrepreneurial skills. This tool can be used by decision makers to evaluate and advise farmers to become more entrepreneurial, and farmers can assess themselves, learning their strengths and weaknesses concerning entrepreneurship.Recommendations and the elaborated tool will be based on:a) an analytical definition and description of relevance of the concept of entrepreneurship and entrepreneurial skills for agriculture reflecting the strategic orientations of farms: a segmentation model is developed, which provides the theoretical basis for the overall project and forms the basis for the diagnostic tool.b) the specification of entrepreneurial skills in relation to the strategic orientation: This analysis will be conducted in case studies following a participatory approach with farmers and representatives of the socio-technical network of farmers.c) the identification and analysis of the economic, social and cultural factors hindering and stimulating the development of entrepreneurial skills. Again, this analysis will be conducted in case studie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'An Assessment of Economic and Social Well-Being of Older People: Evidence from the European Community Household Panel (ECHP)' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and contentThe welfare state programmes in EU countries have aimed at reducing the risk of social exclusion among older people. However, in view of fiscal concerns policymakers in some countries are advocating cuts in basic public pensions and state's social spending. Such policy prescriptions are largely a result of policymaker's view out the level of well-being of older people. This project aims to provide a reliable assessment of the well-being of older people in all EU countries. The project will use the European Community Household Panel, which is the first Europe-wide panel survey base on a harmonised questionnaire. First, literature survey will be provided Next, we assess and compare the economic well-being of older people. We will also use an indicator of economic well-being which is more comprehensive then the money income. In the second empirical exercise we assess the social well-being of older people. Research will be done to see how different definitions of social exclusion can be operationalised. At the end we study socio-economic determinants of the well-being of older persons. It will be examined whether the well-being of older people is determined by their work history, marital status and diversity in sources of economic means.Training content (objective, benefit and expected impact)My doctorate studies in Oxford University will allow me to work exclusively on the proposed research. The expertise, in Oxford University of research on European issues will be highly beneficial. In particular, I will benefit greatly by, working closely with Professor A B. Atkinson who has substantial research experience on issues such as reforms in the, European welfare states and measurement of poverty and inequality in European countries.Links with ind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Statistically Efficient Structured Prediction for Computer Vision and Medical Imaging' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Inference in medical imaging is an important step for disease diagnosis, tissue segmentation, alignment with an anatomical atlas, and a wide range of other applications.  However, imperfections in imaging sensors, physical limitations of imaging technologies, and variation in the human population mean that statistical methods are essential for high performance.  Statistical learning makes use of human provided ground truth to enable computers to automatically make predictions on future examples without human intervention.  At the heart of statistical learning methods is risk minimization - the minimization of the expected loss on a previously unseen image.  Textbook methods in statistical learning are not generally designed to minimize the expected loss for loss functions appropriate to medical imaging, which may be asymmetric and non-modular.  Furthermore, these methods often do not have the capacity to model interdependencies in the prediction space, such as those arising from spatial priors, and constraints arising from the volumetric layout of human anatomy.  We aim to develop new statistical learning methods that have these capabilities, to develop efficient learning algorithms, to apply them to a key task in medical imaging (tumor segmentation), and to prove their convergence to optimal predictors.  To achieve this, we will leverage the structured prediction framework, which has shown impressive empirical results on a wide range of learning tasks.  While theoretical results giving learning rates are available for some algorithms, necessary and sufficient conditions for consistency are not known for structured prediction.  We will consequently address this issue, which is of key importance for algorithms that will be applied to life critical applications, e.g. segm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'INTERNATIONAL MOUSE GENOME CONFERENCE 2001', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The International Mouse Genome Conference (IMGC) meets annually to discuss and report on progress in mouse genetics, and genomics. The recently reported draft sequence of the human genome means that the focus in genomics moves from identifying gene content to gene function. The mouse is the principal model mammalian organism: it has essentially the same gene content as human, but these genes can be experimentally manipulated to determine their function. Determination of mouse genomic sequence is presently a high priority, which will aid gene identification and will provide the framework for mouse mutagenic studies.IMGC2001 will consist of approximately 12 invited lectures who will discuss; the mouse genome sequence and comparative sequence analysis, the use of other model organisms to determine gene function, the bioinformatics tools currently in use and in development and the current state of the art in mouse cloning. All participants will be able to present their data either as selected platform presentation or as posters. In addition, there will be meetings of committees through which mouse genetics business is coordinated; the International Nomenclature Committee and the International Mouse Mutagenesis Consortium will meet at IMGC2001. Other ad hoc groups will be assembled at the conference whose role is to appraise progress and state of the art in several areas of mouse genomics and to produce published reports.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2001-00002-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Molecular-Layer-Engineered Artificial Synapses for Ultralow-Energy Computing' under Horizon Europe.

assistant: **Concept**

Although the rise of artificial intelligence technology greatly benefits our life by improving work productivity, the increasingly high energy consumption required to operate these software programs to cope with huge computational tasks becomes a serious issue. This is mainly due to inefficient data transport between separated memory and computing units (von Neumann bottleneck) in traditional computers. To minimize energy cost while maintaining computing power, this MSCA-PF research project - MoleSynap - aims to design brain-inspired electronic devices. Specifically, MoleSynap will fabricate artificial synapses by emulating biological synapses. These artificial synaptic devices will be designed in three-terminal transistor configuration (synaptic transistors), given their excellent regulation of charge carrier flow during device operation. Current organic polymer-based synaptic transistors suffer from the decreasing long-term device accuracy and high device-to-device variations, mainly due to nonperfect active-layers thin-films prepared by traditional solution-based wet methods. In this regard, MoleSynap will go beyond the current state-of-the-art on two different levels: (1)  employ emerging two-dimensional coordination polymers and ionogel electrolytes as active-layer materials for improving synaptic characteristics, and (2) develop all-dry solvent-free thin-film deposition technology to fabricate active-layer thin-films with high precision and consistency. Overall, MoleSynap aims to significantly advance the field in developing organic synaptic devices for low-energy-cost computing. Moreover, MoleSynap will lay the strong foundation for building my own research group, and fulfill my long term scientific goal of bridging basic science (fundamental polymer physics) and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Aligning and Mutualizing Nonprofit Open Access Publishing Services Internationally (ALMASI)' (ALMASI), addressing dissemination and exploitation.

assistant: **Impact**

The objective of ALMASI is to provide the research community with an aligned, nonprofit, high-quality, and sustainable scholarly communication ecosystem across three world regions: Africa, Europe, and Latin America. This will enable scholarly communities to take full responsibility for innovative, valid, reliable and accessible publishing services and solutions that do not charge fees to readers or authors, commonly known as Diamond Open Access. This aligned nonprofit publishing ecosystem will take into account specific needs across the diversity of disciplines, global regions, and languages. The project will achieve this goal by concentrating on measures that will harmonise and strengthen existing nonprofit publishing services and solutions. ALMASI will establish a framework for knowledge transfer, coordination, and alignment of non-technological publishing skills, services, and solutions. The project will focus on (1) mapping nonprofit publishing services and solutions across the 3 regions; (2) aligned quality support instruments for publishing services; (3) shared training materials and curricula for publishing services, journal editors, and publishing staff; and (4) long-term financial sustainability and OS policies for scholarly publishing. The project will be carried out in the context of the nascent Global Diamond Federation, which is supported by UNESCO.


**Keywords:** scholarly publishing, Diamond open access, scholar-driven, publishing services
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nanotherapeutic platform for lysosomal targeted technology' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Cancer remains a tough challenge, largely because 80% of cancer-driving proteins are considered “undruggable” meaning impossible to target with conventional therapies. Nano-LYTAC project brings together experts in nanomedicine, pharmaceutical technology, and nanotoxicology to answer the burning question: Does complete cancer eradication still remain as an elusive dream? By combining 2 cutting-edge technologies: “Smart Nanotechnology” and “Targeted Protein Degraders (TPDs)”, this project fulfills the goals of Europe’s Beating Cancer Plan by tackling these undruggable proteins. TPDs were created using Nobel Prize-winning bioorthogonal chemistry. Among these, LYTACs (Lysosomal Targeting Chimeras), with their ability to transport intracellular/extracellular cancer-driving protein for selective degradation in the lysosomes, abrogate the cancer pathology. However, despite their promise, LYTACs haven’t made it to clinical use yet, owing to challenges like limited molecule diversity, poor tumor penetration, low bioavailability, and metabolic instability. To transform LYTACs into clinically viable cancer therapies, and to overcome the aforementioned drawbacks, this project will use novel nanotechnological approach to enable enhanced tumor penetration, selectivity, protection, and controlled released of the LYTACs in tumor microenvironment.  Moreover, for the first time, I will design new LYTAC molecules specifically targeting folate receptors that are overexpressed on many types of cancers (e.g.: breast cancers, lung cancer, ovarian cancers). At CATRIN, under the guidance of Prof. Kateřina Poláková, an expert in nanomedicine and their subcellular trafficking, and nanotoxicology, I will develop ""Smart Nano-LYTACs"" with the preclinical proof of their potential. This multidiscipl