RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Tools for integrated studies of the immunoregulatory properties of commensal microbiota' (IMMUNOBIOTA).

assistant: **Innovation**

The infantile microbiota of Western societies is deficient in microbes that support development of tolerance to innocuous antigens, thus predisposing to allergy development. Infantile populations from non-Westernized countries need to be examined to identify protective microbial exposures for the developing immune system. The purpose of this TOK is to build a strong method- and knowledge-based platform focussed on identifying microbes with immunoregulatory properties in the infantile gut flora and testing their mode of action ultimately aiming at rational design of probiotics with desired immunoregulatory properties. For this purpose, we will transfer methodological knowledge between the applicant and two partners in the Associated States Romania and Turkey to permit development of a common protocol for studies of infantile gut microbiota, immune development and protection from clinical allergy. In addition, the non-culture dependent technique T-RFLP will be modified and developed for assessment of infantile microbiota composition in birth-cohort studies. This involves building a data-base from known T-RFLP patterns in combination with culture and sequence data for intestinal bacteria deriving from both Westernized and non-Westernized infantile populations. Further, tools for studies of the effect of selected microbes on the immune system will be advanced and methodology for systematic testing of the immunoregulatory potential of selected microbes in humans will be established in cooperation with a probiotic SME. The project aids in defragmenting the European Research Area and increase its competitiveness by integrating researchers from EU member and Associated States, basic and clinical scientists and academic and company-driven research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'in situ microfluidics to study phytoplankton microscale interactions affecting global carbon capture and coral nutrition' (PhytoSwim).

assistant: **Concept**

Climate change is a global priority, affecting all nations with escalating consequences including temperature increase and extreme weather events. Coral reefs - occurring in EU territories such as Bonaire and New Caledonia - are among the most vulnerable ecosystems. Potential solutions for climate change mitigation may come from phytoplankton, marine microalgae providing critical ecosystem services linked to carbon sequestration and coral reef nutrition. On the one hand, due to their sheer numbers, phytoplankton have a large-scale impact on global CO2 capture, acting as a natural carbon sink. On the other hand, phytoplankton nourish corals, which in turn protect adjacent blue carbon sinks (seagrass meadows, tidal marshes and mangroves), fostering climate resilience.Carbon sequestration and coral nutrition rely on phytoplankton’s complex sensorimotor capabilities. However, despite their immense ecological roles, the dynamics of phytoplankton motility in-situ remain poorly understood. Current research methods rely on bulk and static analyses which fail to capture the dynamic and fine-scale nature of phytoplankton interactions in their natural environments.In PhytoSwim, I will overcome these limitations by developing a cutting-edge methodology to study phytoplankton motility in situ, at relevant spatiotemporal microscales. I will first learn the current state-of-the-art of in situ microfluidics, and then adapt it to detect phytoplankton interactions (OBJ1). Next, I will use this new method to study phytoplankton behavior in the open ocean and in coral reefs, never done before (OBJ2). Expected outcomes: PhytoSwim will deepen our knowledge of phytoplankton microscale behaviors and their ecological impact, while directly contributing to EU’s objectives of advancing climate sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'REsilienT water gOvernance Under climate CHange within the WEFE NEXUS'.

assistant: **Innovation**

With increased water scarcity due to anthropocentric and natural causes, the trade-offs and synergies intrinsic to efficiently allocate water resources to various competing uses have become more polarized. Realizing the importance of an integrated approach in water governance, the RETOUCH Nexus project introduces and promotes the Water-Energy-Food-Ecosystems (WEFE) Nexus as a multi-level and cross-sectoral approach that advocates the EU water economy and, in addition, relies on ecological and social considerations. The overall objective of RETOUCH Nexus is to design and foster integrated, innovative and inclusive Nexus-smart water governance schemes and institutional settings to promote a secure water future in the EU, resilient to climate change. RETOUCH Nexus follows an evidence-based approach to propose, assess and optimize a set of WEFE Nexus smart methods in six different case studies reflecting various cross-sectoral, multi-level and multi-stakeholder water governance contexts. First, the project will monitor water governance by providing a set of Nexus-smart socio-economic and environmental indicators that reflect the cross-sectoral and multi-level nature of water use. Second, RETOUCH Nexus will design integrated and climate-resilient water governance practices that ensure sustainable water systems. It will also develop economic instruments and business models that support robust water management under cross-sectoral competition. Third, RETOUCH Nexus will foster more transparent, inclusive and innovative engagement mechanisms that empower stakeholder and citizen participation in water governance. Finally, RETOUCH Nexus aims to effectively increase the socio-economic and environmental resilience of water governance in Europe by upscaling and endorsing successful a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Phenotypic screening the host antimicrobial responses towards the eradication of Mycobacterium tubercuosis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The co-evolution between hosts and their parasites is one of the most fascinating examples of evolutionary adaptation. However, there is a paucity of information on how the human immune system co-adapts to the parasites phenotypic plasticity, and how it dynamically rearranges its molecular phenotypes aiming to counteract the pathogenic threats. Hence, many therapies for the treatment of intracellular bacteria-related infection (e.g., tuberculosis) are currently obsolete, especially because of the rise in drug resistance. In this framework, the main goal of my proposal is to decipher the unexplored phenotype ‘bar-codes’ of host-pathogen interaction, in order to reversely engineer a drug delivery platform aiming to target infected cells only, and to eradicate intracellular parasites. The final aim will be that of eradicating the severe intracellular pathogens Mycobacterium tuberculosis (Mtb), as it is the major cause of mortality related to bacterial infection worldwide. According to the World Health Organisation, in fact, approximately one-third of the world’s population is asymptomatically affected by TB, with about 9 million new cases of per year (of which 11% are children under 15 years), and 1.4 million of deaths. Despite decades of control programs, TB is still second only to HIV as the greatest killer worldwide due to a single infectious agent (the average killing rate of TB is 3 people per minute). This project will thus explore the molecular bases of Mtb-host interaction. These investigations will be used to engineer 'super-selective' polymeric nanoparticles targeting infected cells only (thus avoiding side effects), and to eradicate intracellular parasite. This will be done while adopting strategies that counteract the development drug resistance. Hence, this pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'the ultimate priming solution scaling up seed storability length' to be submitted under Horizon 2020.

assistant: **Abstract**

Nelson Garden’s ecological VITASEED method is the first and only priming method that allows for long-term storage of primed seeds. Seeds that have been treated by seed vitalisation will have all the traditional benefits of priming such as faster and more uniform germination, higher rate of germination and stronger seedlings, which altogether helps to increase the yield. In addition, the method not only improves the vigour and germination capacity of the seed in the short term, but it also permits the seed to keep the enhanced properties over time. This is a sharp contrast to current methods of seed priming where the seeds mostly have to be used within the same season. The extended shelf-life, paired with the methods’ remarkable cost, resource, and time-effectiveness, will make it possible to apply seed priming techniques to a much wider range of species and varieties than what is possible today. Nelson Garden’s vitalisation method can therefore significantly move the borders of what can be achieved with seed priming and for how long. The market introduction of this unique and patented seed priming technique can increase from one side the profitability of both growers and the seed industry across Europe, while from the other is meeting the exigencies of an overcrowded urbanized world, constantly looking for weather- resistant solutions allowing to grow more on smaller areas. In fact, the  most critical challenge of the European agricultural sector today  is to keep up production and productivity to ensure food security, while at the same time shifting agriculture onto a more sustainable and resource-efficient growth trajectory. VITASEED will help European agriculture respond to these challenges by providing:  a) a commercially affordable solution b) reducing chemicals  a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Innocent Children or Security Threats? European Children Born of War' (EuroWARCHILD).

assistant: **Concept**

How can we ensure that children born of war do not pay for the sins of their parents? Political debates about how to address the plight of children born of foreign fighters to ISIS/Daesh make this an acute concern in Europe today. The European debates are polarized; some argue that socialization of these children will transform them into the next generation of terrorists, while others argue that they must be assumed innocent with rights to citizenship in European countries and state protection. How might we understand, respond, and address the needs and rights of these children raises the fundamental question of how we understand children of the enemy, as innocent individuals or security threats? Further, it is important not to repeat previous historical mistakes. By learning from the past, we can ensure that we will not need to issue apologies for wrongdoings in the future. After World War II, children conceived by enemy soldiers experienced shaming, harassment and isolation. We know that some of the children conceived through conflict related sexual violence during the Bosnian war of 1992-1995, were rejected and adopted, whereas some remained with their mothers under difficult circumstances. These war children were long silenced, but with time, they have formed vocal groups who argue for the right to be seen, heard, and recognized. Their core message is that the sins of their parents are not theirs to bear; they are not the enemy. EuroWARCHILD develops methodological innovation and combines theory development, life history interviews and text analyses to investigate how a child born of war can become a security concern, and what it entails for the child who does. This project is the first to comprehensively examine different groups of war children in the European cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'HyperSpectral Terahertz neAR-field nanoscope exploiting miniaturized frequency-combs' in the context of a Horizon Europe call.

assistant: **Objectives**

‘STAR’ aims to increase the technology readiness level of the state-of-the-art graphene-integrated, miniaturized frequency comb (FC) quantum cascade laser (QCL), operating at terahertz (THz) frequencies, devised under the ERC consolidator grant ‘SPRINT’, and develop a detector-less sensing/imaging demonstrator apt to the translation of this technology to industrial end-users. The focus is on providing a compact, low-cost, hyperspectral, nanoscale imaging system, which creates amplitude- and phase-resolved images, employing the not-invasive broadband THz-frequency light of a metrological frequency-comb source, without making use of an external detector. This nanoscope ensures 40-100 nm spatial resolution, >100 times smaller than the THz free-space wavelength, coherent detection and mapping of the THz optical response of materials over the continuous 2-5 THz bandwidth provided by a fully stabilized THz QCL FC, with noise-equivalent-power <10pW/√Hz and fast (<ms/pixel) acquisition rates, far exceeding the performances of commercial time-domain spectroscopy near-field systems.Specific objectives are to manufacture a compact, portable and user-friendly THz hyperspectral nanoscope, validate its core technology with commercial end-users and at trade-shows and evaluate opportunities for THz FC self-detection nanoscopy, identifying novel end-user applications, with a detailed market, IPR and regulatory compliance study. By the end of this programme, I plan to identify a solid exploitation route by directly interacting with THz instrument producers and with targeted commercial end-users.Pushing forward a solid commercial exploitation route, STAR prospects new directions and long-term impacts on many interdisciplinary fields crossing engineering, biology, medicine, cultural herita
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Non-amyloid-related hippocampal network dysfunction as an early biomarker of Alzheimer’s disease' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Alzheimer's disease (AD) is the most common form of dementia. Generally, it is diagnosed in people over 65 years of age, although the less prevalent early-onset Alzheimer's can occur much earlier. As of September 2010, this number is reported to be 35.6 million worldwide. AD develops for an indeterminate period of time before becoming fully apparent, and it can progress undiagnosed for years. Currently used treatments offer a small symptomatic benefit; no treatments to delay or halt the progression of the disease are as yet available. Therefore, an early marker of AD might be a useful new tool to improve life quality of patients.It is well documented that AD patients and animals models of AD exhibit massive reorganization of hippocampal and cortical networks, initiated by an early imbalance between excitation and inhibition. This alteration of hippocampal networks might lead to early perturbations of hippocampal oscillatory activity. Brain oscillations in the theta (3-12Hz) and gamma frequency bands (30-250Hz) are crucial for supporting normal cognitive and executive functioning. Accordingly, increasing evidence suggests that oscillatory activity in theta and gamma range is altered in AD. Despite the genetic and cell biological evidence that supports the amyloid hypothesis, it is becoming clear that AD etiology is complex and that Aβ alone is unable to account for all aspects of AD, i.e. amyloid deposits might be present in cognitively normal individuals, whereas some AD patients show no amyloid plaques. These results strongly suggest that non-amyloid factors may also be responsible for hippocampal networks dysfunction. The present proposal opens an original and innovative avenue of research for understanding the cellular mechanisms responsible for early cognitive abnor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of a Slat with Integrated Electrical Deicers for Icing Wind Tunnel Tests' under Seventh Framework.

assistant: **Concept**

There are presently two principle alternatives to engine bleed air Ice Protection on mid to large size aircraft; these are known as ‘electro-expulsive’ low power and ‘electro-thermal’ systems.Whilst electro-thermal systems can perform very successfully when provided with adequate electrical power, an electro-expulsive system can be highly energy efficient and therefore extremely attractive on platforms where generator sizing is critical or less power is available for the ice protection system.Neither system in isolation necessarily offers an ideal IPS solution for all future wing types. The purpose of this integration study is therefore not only to investigate the integration of the IPS technologies to a Wing Slat but moreover to conceive the most appropriate combination of the technologies for Wing Slat ice protection.  These ‘Hybrid’ systems have been used successfully on horizontal stabilizers on smaller aircraft types, but further work is required in the application to larger platforms and wings.In addition to the CfP scope, GKN would like to offer to integrate its own proven electro-thermal technology alongside the Associates’ electro-thermal and expulsive technologies to enhance the value of the integration activity and form a technology alliance to increase the probability of finding a successful solution.In addition to functionality of the overall IPS the ‘actuation’ system aspects must be seamlessly integrated into the aircraft structure and electrical architecture.  The current A320 slat is designed specifically to incorporate an engine bleed air IPS; therefore any change to this paradigm requires a carefully controlled design and integration approach and thorough understanding of wing performance requirements together with structural design ability in metalli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Photonic devices using high-temperature superconductive thin films' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

This is a project involving 4 research groups: 2 in our University, one in our same area, and one industrial partner, Pirelli Cables, in Italy, who together with Red Electrica de Espana will financially support the project. The objective of the project is to develop applications of high-temperature superconductors (HTS) to photonic devices. The project has four parts: 1. To develop the technology of depositing HTS thin-films on electrooptic substrates. This part will be carried out in the Institut de Ciencia de Materials de Barcelona (ICMAB). 2. To fabricate optical waveguides on electrooptic substrate. This part of the project is technology already commercialised by Pirelli Cables. 3. To design photonic devices that take advantage of the low-loss of the HTS materials. 4. To fabricate a resonant Mach-Zehnder modulator to demonstrate the advantages of using HTS materials instead of normal conductors in photonic devices. Edouard Rozan will participate in parts 3 and 4 of the project.