RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Engaging Urban Youth: Community, Citizenship, and Democracy'.

assistant: **Concept**

Disadvantaged youth in urban environments often experience marginalization and disenfranchisement that can lead to disastrous consequences for them, their families, and wider society. We know that successfully engaging these young men and women in the institutions, communities, and contexts in which they live and building their capacity as social actors can be a critical factor in their positive development as individuals and future role as citizens. Yet, there is still relatively little known empirically about the specific contexts, strategies, and mechanisms through which disadvantaged urban youth can be most effectively engaged. This research is designed to develop the expertise of the experienced researcher to enable him to contribute much needed in-depth knowledge of how best to engage young people as citizens both civic and political actors with autonomy and responsibility for contributing to the common good. This work will be done through a comparative case study in three Irish cities. The methodology will involve a consultative process with designated stakeholders in each city including local politicians, policy leaders, service providers, service users, youth representatives and youth workers.  It will involve field observations and interviews with young men and women in three selected case study cities, each having a distinct urban identity: Large multi-cultural (Dublin); Post-Conflict ( Belfast) and Smaller Regional City (Galway).  Dissemination and Public Engagement are central to this proposal.  The research will impact on the participating stakeholders by providing tangible and accessible research findings. It will impact on the field of urban youth studies by offering a comparative framework applicable to other urban contexts in Europe and globally. The i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New impetus to materials research - democratizing a frontier research tool' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Our society is driven by constant technological progress, which crucially depends on advances in material science. The bottleneck of such advances is to see deeper into and understand better the molecular structures, which is limited by tools that are either i) accessible to many, but limited (and already fully exploited) in performance, or ii) are of high performance but restricted to only a few with large-scale infrastructures, and greatly limited by availability and cost.One of the most effective and prolific of materials analysis tools is high-energy-resolved X-rays capable of revealing high-definition molecular structure of new materials in working conditions. This is however only available at large, €1BN X-ray sources, with little and difficult-to-obtain machine time for R&D performers. This discourages most potential users and makes life hell for the few who try. Consequently most of the industrial R&D sector, which could benefit most from these tools, is not even aware of these opportunities.LynXes proposes to pack this technology into a self-sufficient tabletop solution, offering to disrupt the entire materials analysis sector and open up a whole new market worth around half a billion to a billion euros a year. We are convinced that this novel family of materials analysis methods could be a game changer in the research and development in many fields. The possible use cases range from developing novel materials for batteries or fuel cell systems, understanding and improving nuclear waste management, boost the performance of waste water treatment, etc.Our mission is to open new horizons for industrial and academic R&D by democratizing the access to high-energy-resolution X-ray spectroscopies (HERXS) technology. We believe that our technology will create a better
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The LIM-homeodomain transcription factor islet-1 is a genetic marker for isolation and generation of cardiovascular progenitor cells' to be submitted under Sixth Framework.

assistant: **Abstract**

The purification, renewal and differentiation of native cardiac progenitors would form a mechanistic underpinning for unravelling steps for both cardiac lineage formation and regeneration, and their links to forms of congenital and adult cardiac diseases. Taking advantage of a developmental lineage marker for undifferentiated cardiogenic precursors as a requirement for a heart-specific origin, we have identified in the post-natal heart a novel cardiac cell type. The LIM-homeodomain transcription factor isle t-1 (isl1) marks a cell population that makes a substantial contribution to the embryonic heart. Tamoxifen-inducible Cre/lox technology enables selective marking of this progenitor cell population including its progeny, at a defined time, and purification to relative homogeneity. Co-culture studies with neonatal myocytes indicate that isl1+ cells display a highly efficient conversion to a mature cardiac phenotype. Our hypothesis is that isl1 is a unique marker to isolate a population of cardiac precursors f rom the intact heart that can differentiate in vitro into functioning myocytes and to generate cardiogenic precursors from mouse embryonic stem cell systems during cardiogenesis. Our specific aims are: 1) To determine therapeutic efficacy of isl1+ cardiobl asts by transplantation into normal and diseased myocardium utilizing mouse models. 2) To establish optimal conditions for generation and differentiation of isl1+ progenitors in the mouse embryonic stem cell system. 3) To identify specific molecular pathwa ys that drive the differentiation of isl1+ cardioblasts into specific cardiomyocyte cell lineages. (Laugwitz K-L, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin L, Cai C-L, Lu M, Reth M, Platoshyn O, Yuan J, Evans S & Chien KR. Postnatal isl1+ card ioblast
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Disconnected research and development: The (temporary) spatial patterns of innovation' (DISCO).

assistant: **Concept**

Scholars recently observe an increasing spatial disconnect between research and development (R&D) activities within global firms, in particular from emerging markets. These firms off-shore their research activities to centers of state-of-the-art knowledge while they might keep product development closer to their original locations. This is of major concern to our society because this spatial split channels global knowledge flows and affects the ability of regions to produce innovative output such as climate-friendly engines or vaccines against new viruses, and has further implications for the economic and social welfare of regions. This project aims at understanding the dynamics of spatial (re-)organization of R&D in relation to firm development as well as economic shocks and social crises, such as the Wall Street Crash of 1929 or the current COVID-19 pandemic. Because we still know too little about how stable this spatial disconnect is, based on initial evidence that it might only temporary exists, DISCO uses information from patents to build an indicator and a firm-typology revealing the global patterns of which type of R&D activity is performed at which locations. The project provides a quantitative measure for the type of R&D activity that goes beyond the qualitative measures often used to study this phenomenon. Applying these indicators to almost 200 years of historical patent data yields insights into the effect of economic shocks on the spatial organization of R&D. Further, it reveals similarities and differences between the development of currently emerging firms and early activities of today’s global players. This can yield new evidence on innovation capability building and successful development trajectories in R&D internationalization. The findings provide a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Accurate Diagnosis of prostate cancer using Optoacoustic detection of biologically functionalized gold Nanoparticles  - a new Integrated biosensor System' (ADONIS) targeting Sixth Framework.

assistant: **Abstract**

Prostate Cancer is the most common cancer disease for men. The choice of treatment and its efficiency relies strongly on the stage in which the cancer is when diagnosed. Screening procedures like digital rectal examination (DRE) and free prostate specific antigene (PSA) level testing are well established but lack accuracy, yielding only 80% of prostate cancers diagnosed in an early state.The objective of ADONIS is the proof of concept of using optoacoustic imaging in combination with biologically functionalized nanoparticles as an integrated biosensor based system for accurate diagnosis of prostate cancer.The idea behind ADONIS is to combine the superb biosensor selectivity of immunogold labelling with the peculiar optical properties of gold nanoparticles. It was recently shown that gold nanoparticles have very strong surface plasmon absorption of light that is sensitive to their shape and dimensions. The absorption of light from these localized absorption centers generates pressure waves, which propagate through the tissue to be detected and analyzed with techniques similar to conventional ultrasonic imaging. Exploiting this effect in combination with the possibilities of biological targetting of nanoparticles using a tumour marker like prostate specific membrane antigen (PSMA), the expected result is a new concept for biosensor based diagnosis of prostate cancer which will allow the development of overall accessible, cost-efficient medical instruments for accurate diagnosis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Study of the environmental compatibility of industrial by-products' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The investigation will be related to the leaching behaviour of several industrial by-products. The characterization of the long term leaching of these materials is one of the most important points in this research area to carry out in the future. The development of new leaching tests to evaluate this long term release of contaminants is essential to have a good knowledge of the environmental compatibility of these by-products. The evolution in time of the release is decisive for their further utilization. The release of elements to the soil has to be well known and controlled to avoid the presence of contamination problems. The Forschungsgemeinschaft Eisenh|ttenschlacken is completely equiped to carry out this research. The previous investigations developed in the institute allow to expect a success result in this investigation. The results obtained would be very interesting not only for Germany, even for the rest of the European countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Exploring the Formation and Adaptation of the Brain Connectome'.

assistant: **Innovation**

Endeavors to explicate the architecture and functional capacities of the human brain confront its vast complexity most pronouncedly when describing the interactions and interconnections of its neuronal processing units. Efforts in this direction gave rise to the notion of connectomics, research investigating large-scale interactions mediated by axonal fibers (structural connections) or characterized by causality or co-activation of distributed domains (functional connections). The processes that shape the connectome into its mature form or the mechanisms that underlie the dynamics of re-organization during disease are yet poorly understood. They are important for both basic research and in a clinical context. The aim of the proposed project is to construct and utilize an image processing framework for studying the dynamically shaping structural and functional brain networks. The project will focus two phenomena that offer insights into related mechanisms from different perspectives: the developing brain during in utero maturation and the re-organizing brain during adaptive processes. The project FABRIC will build on recent advances in fetal functional magnetic resonance imaging techniques including the breakthrough in observing resting state networks in fetuses. Diffusion tractography will be utilized to explore the emergence of large-scale anatomical pathways that presumably render information exchange channels for the forming of functional activity. These observations will be integrated into a temporal atlas of fetal connectome development.  In the clinical setting, we will investigate the influence of fetal neurodevelopmental diseases and adult brain tumors on the structural and functional network topology. Ultimately the project will result in insights into the rela
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Epch' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The project aims at training specialists and decision makers at cultural institutions in the field of management of on-line cultural heritage information through an Euro Summer School. The target audience includes representatives of libraries, museums, archives, as well as University lecturers/professors in the related fields in Central and Eastern Europe (CEE). The school will address specific multidisciplinary issues related to the electronic presentation of cultural heritage information on European grounds.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The impacts of ocean fine-scale whirls on climate and ecosystems' (WHIRLS) under Horizon Europe.

assistant: **Objectives**

WHIRLS is about small processes having large-scale impacts. Heat and carbon are the currencies of regional and global climate, constantly exchanged between the ocean and the atmosphere. This exchange is strongly influenced by fine-scales ocean eddies—whirls—that flux heat and carbon towards, or away from, the air-sea interface. When the ocean gives up heat and carbon to the atmosphere, climate is warmer and wetter, and vice versa. Carbon that is fluxed towards the air-sea interface, where sunlight is available, can be taken up by phytoplankton that form the base of the oceanic food web. Eddies and fronts alter vertical nutrient fluxes and ocean stratification which help shape biodiversity and ecosystems. The proliferation of fine-scale processes, and their interdisciplinary and large-scale impacts are poorly understood. In WHIRLS we will use a synergistic and interdisciplinary approach to study fine-scale processes across a continuum of scales (1–100 km) and assess their impacts on air-sea exchange and marine biogeochemistry and biodiversity. We focus on the Agulhas Current System around South Africa because it is a global hotspot of eddy activity, ocean-atmosphere heat exchange, and marine productivity and diversity It is also a region that plays a key role for the global ocean circulation and global climate and climate change. We will use multiple coordinated observing strategies, including research vessels and a large ensemble of autonomous platforms, to collect physical, chemical, and biological datasets across scales. These data will be supplemented by high-resolution models of the ocean and the atmosphere, developed with a focus on the Agulhas Current System, as well as the latest data science methodologies. WHIRLS will improve the understanding of fine-scale proc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Rapid and Inexpensive Diagnosis of Heparin Induced Thrombocytopenia Using Glycan Arrays Containing Synthetic Glycosaminoglycans' (HITCHIPDIAG) under Horizon 2020.

assistant: **Objectives**

Rapid and Inexpensive Diagnosis of Heparin Induced Thrombocytopenia Using Glycan Arrays Containing Synthetic GlycosaminoglycansHeparin, a complex glycosaminoglycan (GAG) carbohydrate, is the most commonly used anticoagulant. Twelve million patients in the EU are treated annually for conditions including acute coronary syndrome, deep-vein thrombosis and cardiopulmonary bypass surgery. Heparin-induced thrombocytopenia (HIT) is a dangerous adverse side effect of heparin administration. HIT-II develops after major surgery or dialysis and results in infarction, multi-organ failure and 20% mortality. In Europe 100,000 patients develop HIT-II annually.Currently, two HIT-II diagnostics are available. The HIPA and MAIPA tests detect antibodies against a complex of heparin and platelet factor 4 but suffer from low diagnostic specificity and accuracy. Faster, more reliable and cheaper methods to diagnose complications after administration of heparin are needed to improve patient wellbeing and reduce costs.The ERC Advanced grant AUTOHEPARIN yielded an instrument for the automated assembly of defined oligosaccharides. GAG glycan microarrays were produced by printing GAG oligosaccharides onto surfaces and used to screen patient blood. Specific glycan markers of high diagnostic value were discovered to detected HIT-II within minutes and reliabilities well above existing tests. The overall goal of the project is to establish the business model for a company that will focus on the production of GAG glycan arrays as HIT diagnostic. Specific activities include: 1) Development of standard protocols to detect HIT-II using GAG glycan microarray; 2) Plan and cost structure for GAG arrays production; 3) Analysis of the IP space and development of an IP strategy; 4) Evaluate potential markets a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Grinding of scrap tyres into rubber powder, its applications and marketing'.

assistant: **Concept**

This project concerns recycling of scrap automobile tires by grinding them to a rubber powder with very small particle size. The project offers a considerable improvement of the grinding technology: the small size of the rubber powder particles is obtained at considerably lower cost as compared to all other known rubber grinding technologies. This rubber powder can then be used as a secondary raw material in a number of applications. The aim of this project is to bring the improvement of the rubber grinding technology from the laboratory prototype model to an industrial scale, investigate already existing as well as potentially new application areas for the rubber powder and thus establish the new product on the European and World market. The overall result of this project would be a technological advancement of the whole Europe by introducing an economically viable and environmentally sound waste handling option for scrap automobile tires.