RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Fully automated and integrated microfluidic platform for real-time molecular diagnosis of Methicillin-Resistant Staphylococcus Aureus (MRSA)' (MRSA) targeting Sixth Framework.

assistant: **Abstract**

Methicillin-resistant Staphylococcus aureus (MRSA), a virulent organism resistant to many drugs, is responsible for most nosocomial and community-acquired infections. It can cause life-threatening disease, and treatment options are limited. Effective and rapid diagnostics is a strategic key element in the campaign against the spread of MRSA, allowing infection surveillance and control measures as well as more efficient patient treatment, and overall decreased health cost.The MagRSA project aims at the development of a new diagnostics platform that will provide a fast, simple and accurate identification of MRSA from clinical samples. The diagnostic protocol relies on a new and clinically validated procedure that consists in a direct one-step enrichment of MRSA present in either nasal, inguinal or wound swabs, followed by DNA extraction of immunocaptured bacteria and their identification by multiplex sequences amplification using quantitative PCR.This protocol will be implemented with a simple 'hand-off' system based on:(1) advanced microfluidic magnetic nanoparticles manipulation technology allowing efficient capture and extraction of target bacteria and nucleic acids, and(2) novel strategies for the integration of full operations required for the entire nucleic acid analysis chain in a microfluidic platform.Steps as sample preparation signal amplification by multiplex PCR and detection of multiple genes simultaneously will be integrated and automated in single fluidic chip. MagRSA project will bring together high-tech SMEs and advanced hospital/academic laboratories that are mutually independent leaders in their fields with complementary competencies. The ultimate objective is to reach a pre-clinical validation of the proposed diagnostic tool that not only addresses the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Seventh International Conference on Nucleus-Nucleus' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The Seventh International Conference on Nucleus-Nucleus Collisions is part of a conference series with a 3-year cycle. The series started in 1982 at East Lansing (USA); subsequent meetings were held at Visby, Sweden (1985), Saint-Malo, France (1988), Kanzawa, Japan (1991), Taormina, Italy (1994) and Gatlinburg USA (1997). It is the most important international conference series on heavy-ion physics world wide, as it provides a complete overview over the development in the field of nuclear collisions from low up to the highest incident energies. The main topics covered at these conferences have been and will be - Nuclear structure at the limits of stability (nuclear structure, astrophysics, use of radioactive nuclear beams) - Heavy-ion collisions at low and medium energies (liquid-gas phase transition of nuclear matter, equation-of-state of nuclear matter hadron properties in hot and dense nuclear matter) - Nuclear reactions at ultra-relativistic energies (phase transition to the quark-gluon-plasma, extreme baryon densities.At the upcoming conference, world-leading experts in these subfields will be invited to give an exhaustive overview over the developments in these areas and to report on the significant advances of the field within the last three years. In all research directions, tools (accelerators, detectors) have been developed to address new degrees of freedom and new regimes of energy and density. The impact of technologic advancements on the results obtained in fundamental research will discussed. A critical evaluation of the whole field of heavy ion physics and a discussion of the development potential will be essential in view of various plans to upgrade or extend existing heavy-ion facilities world wide.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00019-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'REprogramming Pancreatic Alpha-cells for Insulin production Restoration in diabetes'.

assistant: **Objectives**

Diabetes affects some 500 million people worldwide (estimated 700 million by 2045), causing over one million deaths annually. The disease results from the loss / dysfunction of pancreatic islet insulin-producing β-cells, leading to chronic hyperglycemia and severe complications. Current treatments are symptomatic and fail to restore long-term glucose regulation, stressing the need for a transformative curative approach.Our proposal leverages α-cell reprogramming as a novel therapy for the restoration of insulin-production in situ, i.e. in the pancreas of diabetics. Islet α-cells remain abundant in diabetic patients and, along with δ- and γ-cells, they possess intrinsic plasticity, meaning that they can “learn” to produce insulin (Nature, 2010 & 2014; Diab Obes Metab, 2016; Nat Cell Biol, 2018; Nat Comm, 2021). Recently, we have shown that if all islet non-β-cells were converted into insulin producers, the islets containing only insulin-producing cells would be perfectly viable and functional, keeping optimal glucose homeostasis (Nat Metab, 2024). We have also reported that genetically reprogrammed human α-cells can secrete insulin and restore normal glucose levels when transplanted to diabetic mice (Nature, 2019). These findings establish islet non-β-cell reprogramming as a viable innovative strategy for diabetes cure.Here, we aim at developing a first-in-class, non-genetic therapy to induce in situ α-cell reprogramming using small molecules. From a targeted screening we identified six FDA-approved compounds that induce insulin expression above a reprogramming threshold in purified α-cells from 2 donors. We will now explore their mechanism of action re the functional conversion and conduct preclinical studies in healthy and diabetic mice to assess reprogramming efficien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Assessment of arc tracking hazards in high voltage aerospace systems', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Electrical wiring systems on aircraft have traditionally operated at low voltages (115V AC / 28V DC). The insulation system used in the wiring systems is not subject to significant levels of electrical stress but thermal and chemical degradation / mechanical damage can allow the insulation to be breached. If two wires / a wire and a ground plane are then breached by a conductive fluid (from a leaking pipe / condensation) or by making contact with a conductive surface (such as a bulkhead), current will then flow. The magnitude of the current is then limited by the electric arc that forms between the wires with the arc voltage being of a similar magnitude to the system voltage. These arcing events are therefore difficult to detect given their intermittent nature and the relatively small levels of current that flow. However, they can cause significant damage. A recent example was the loss of an F35B where an electrical fault caused by an incorrectly installed bracket then caused the failure of a hydraulic line and a fire.  As we development hybrid and all electric aircraft, the voltage level of the on-board electrical systems is expected to climb to 0.75-3kV (the lower voltages being used for VTOL air taxis and the higher voltages being used in regional jet applications such as the E Fan X demonstrator). The use of higher voltages, the change in component technology (such as using screened instead of unscreened cables), system configuration (grounded / ungrounded) and use of composite structures within the aircraft will all impact on arc tracking. This project aims to deliver a clear understanding of the arc tracking hazard in these new higher voltage systems and describe ways in which it can be quantified and mitigated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '(P,C) and (O,O) well-defined gold(III) complexes for the development of new gold(III) catalytic processes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Over the last 20 years, gold catalysis has become a very efficient method for the rapid construction of complex and highly functionalized molecules. However, gold catalysis is mainly limited to the activation of π-systems by Au(I) complexes. Comparatively, Au(III) catalysis is poorly developed due to the rarity of stable but reactive Au(III) complexes. But recent studies showed that judicious ligand design enables to stabilize Au(III) complexes and that switching from Au(I) to Au(III) leads to completely different reactivity and selectivity.The Gold3Cat project envisions to elaborate a library of well-defined Au(III) complexes and to develop a new facet of gold catalysis thanks to the unique properties of these Au(III) complexes. The first step will consist in preparing a range of stable Au(III) complexes relevant to catalysis (WP1). P-Based chelate and pincer complexes are proposed, as well as (O,O) chelated complexes featuring a catechol moiety. The electronic properties of the new Au(III) complexes will be thoroughly studied to enable rational catalytic development and optimization. Given its importance but current limitations, efforts will concentrate on hydroarylation (WP2). This includes asymmetric versions in which the square-planar geometry of Au(III) should impart enhanced chiral induction (WP3). The ability of P-based pincer ligands to stabilize Au(III) carbene complexes will also be studied, and catalytic transformations taking advantage of the high electrophilicity of these unprecedented species are targeted (WP4).The Gold3Cat project is very ambitious both synthetically and conceptually, but it is built on solid foundations. It combines ligand design, advanced organometallic studies and important catalytic applications. Given the dynamism of the host group
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New industrial furnaces of higher thermal efficiency through intensification of heat transfer from flames' in the context of a Fourth Framework call.

assistant: **Objectives**

Large energy savings and therefore reduction of CO2 emissions may be achieved in industrial high temperature furnaces by heat recovery on flue gases, mainly for combustion air preheating. However, experience shows that available heat recovery techniques are seldom used at their maximum efficiency. This results from several drawbacks. Air preheating in conventional burners leads to an enhanced production of NOX. Furthermore, high temperature peaks may be locally reached resulting in load overheating. Therefore, temperature uniformity is more then often achieved by maintaining slow heating rates. The general purpose of the proposed research programme is the improvement of high temperature equipment i (mainly furnaces) through an optimised use of new techniques of intensification of heat transfer from flames. Among these techniques: Iow-NOx burners combining high air preheat with staged or flameless oxidation combustion, high velocity jet burners or pulsating burners, oxygen enrichment. Optimisation of these techniques will be carried out in two very energy intensive sectors: glass and ceramics. The programme proposes a theoretical and experimental study of the interaction between the burner design and the heat transfer to the charge. It proceeds through three consecutive steps: 1. Fundamental research - Further developments and adaptation of advanced furnace models to cope with intensified combustion and heat transfer techniques. Improvement of NOX formation models. - Validation of the models, measurement of heat transfer coefficients by convection and radiation in intensified conditions in laboratory-scale furnaces. - Generation of model based rules for the design and operation of glass/ceramics intensive furnaces. 2. Application of intensification techniques in laborato
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'A Global Network for the Search for High Frequency Gravitational Waves'.

assistant: **Innovation**

The overarching goal of the GravNet project is to develop, test and deploy a novel experimental platform that could enable the first detection of gravitational waves (GWs) in the frequency range of MHz to GHz, thereby providing a new and unique window into astrophysical processes that have so far eluded observation. The first detection of gravitational waves by LIGO in 2015 ushered in a new era of fundamental physics. Since then, a network of ground-based GW interferometers has probed the frequency range from 10 Hz to 10 kHz, detecting nearly a hundred mergers of black-hole and neutron-star binaries. In 2023, a signal at much lower frequency, in the nHz band, was detected by timing radio signals from pulsars. The race is now on to explore other bands. Of particular interest in this context is access to the MHz-GHz range, as in this range signals may be generated copiously by events such as primordial-black-hole-merger, by the dynamics of ultra-light dark matter overdensities or violent phenomena in primordial cosmological times - all processes related to some of the most pressing open questions about our Universe.The use of cavities in strong magnetic fields has been identified as one of the most promising techniques to search for high-frequency gravitational waves. So far, efforts were focused on cavities with small volumes that are tuned to search for axion-like particles. By contrast, the GravNet scheme is based on combining different technologies and methodological approaches to measure synchronously cavity signals from multiple devices in magnetic fields operated as a network across Europe, increasing the sensitivity to high frequency GWs (HFGWs) by several orders of magnitude compared to current approaches. In this way, GravNet will open up a new, vast parameter s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European Television? a workshop to prepare a new agenda for science communication', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Prophecies of the impact of science in the 21st century are awesome. Global warming, new medicines, etc. will all impact the general public. The main audio-visual media, television and internet, have a huge responsibility and opportunity to engage the pu blic's interest.  This project will prepare a strategy prior to FP7 to harness the appeal of popular strands of TV to create a new awareness and interest in science. It will reflect the new philosophy of science in society" with a focus on science in TV programmes rather than committed science programmes which often play to the converted.  The aim is to find creative ways of introducing much more science into Drama, Wildlife programmes and Sports, which command huge audiences.  This project will bring to gether in a two day event leading European actors, notably TV executives, scientists, science communicators, TV writers and producers. The event will be held at the European Science Congress, ESOF 2006, with many actors present. AV examples to inspire discussion will be: a) The EuroPAWS Project, whose action research on TV Drama made an important start on this agenda in FP6. Examples from its Docu-Drama festival will attract TV people to sample new ways to project science for large audiences, and fuel their own imagination. b) The European Physical Society pilot project linking science to natural phenomena using a TV web package, linking method and content c) A specific science strand, Space Science, to survey all TV/web options.  The event focuses on how the aim of bringing science into popular European TV can be furthered in the context of FP7. Models will be explored for European collaboration, how best practice can be spread and how targeted money can act as a catalyst. The goal will be to produce an agenda for the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'NIPCO - New Image Processing for the characterisation of olives and other fruits' (NIPCO) under Fourth Framework.

assistant: **Objectives**

Objectives:This project intends to improve and upgrade the existing technology with the objective of solving two specific and quite extended problems in the agrofood industrial sector: The classification of fresh and semi-elaborated products of agricultural origin and the determination of their quality in a reliable and efficient way.In view of this objective several technologies, developed in other industrial sectors such as robotics, artificial vision and automated systems, will be utilised in order to solve problems of the agricultural industry sector.This will bring the benefits of these disciplines and applications to a sector which up to now doesn't have the appropriate technological knowledge and means to solve them.The specific objectives are:1.To develop an artificial vision system for the quality inspection of olives and potatoes. This includes the design of the lighting and camera configuration, the SW development for the information collection from the obtained images and the development of the classification SW for product selection.2.Implementation of the algorithms in a specific platform for real time image processing. A user graphic interface will have also to be developed.3.Development of a high speed product handling line. The product transport line may be adapted from other systems. A system including the high speed synchronization and separation modules as well as product reject mechanisms will have to be developed integrating them with the transport and camera modules.4. Pilot testing of the image processing and auxiliaries integrated system installed in the project prototypes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The VIRTUAL Centre for Integration of INNOVATIVE synthesis and Processing methods for SUSTAINABLE advanced Materials operating under Extreme Conditions' (SUPERMAT) targeting Horizon 2020.

assistant: **Abstract**

The main objective of the proposal is to create a virtual centre to boost IMNR position in Bucharest-Ilfov region and Romania by increasing the knowledge and technology degree of innovation potential for sustainable advanced materials operating under extreme condition. Development and understanding of these materials open new opportunities to enhance the competitiveness of regional and National SMEs in the priority machinery and equipment sector.  The  concept of the virtual centre SUPERMAT stands on: Significantly improving scientific capacity of IMNR in novel nano/micro structured materials under extreme conditions; Implementing innovation actions and boosting entrepreneurship; Improving the technology transfer and services offered by IMNR at Bucharest-Ilfov region, National and European levels; Extend synergies between IMNR and the 6 Research Centres from France, Spain, Italy, Sweden and Italy and ensure continuation of the virtual centre after project end.The proposed support activities will foster the progress the field by: improving existing modelling and simulation tools for ab-initio design of novel multimaterials for extreme environments, select case studied materials with high application potential in energy equipment and machinery, propose best available technologies for selected materials, propose characterisation methods to be certified for future standardisation,  organise specific workshops, seminars and conferences with industry, local and National Governmental Agencies, ONGs, organise summer schools and training for young researchers from IMNR, propose an European curricula for PhD students in the field of materials for extreme conditions, dissemination of the results on large scale. The sustainability and continuity of the virtual centre SUPERMAT will