RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Lipids as promising BRidge between novel disease InsiGHts and improved Therapy' to be submitted under Horizon Europe.

assistant: **Abstract**

Recent insights revealed new, decisive roles for lipids in cardiovascular disease, chronic kidney disease, cancer and chronic inflammation. Lipid targeting may offer novel treatment opportunities for these four high-impact diseases, complementary to the currently available, insufficiently effective therapies. However, developing effective diagnostic, preventive and therapeutic solutions requires deeper insights into lipid metabolism in disease as well as improved methods of lipid detection and imaging. Furthermore, an increasing interest in lipids in clinical applications, demonstrated by our associated partners, generates job profiles requiring novel, lipid-focused, interdisciplinary training. LipiBRIGHT is the first lipid-focused ITN designed to address the unmet medical need to i) better understand lipid metabolism in disease and ii) train young scientists in the emerging lipids field, associated technologies and clinical applications, this to speed-up understanding of lipid-associated diseases and translation into novel strategies for disease diagnosis, prevention and treatment.LipiBRIGHT comprises 6 forefront-running, interdisciplinary and intersectoral research institutes and 2 SMEs with complementary expertise in lipid-associated diseases, technology and translation, supported by 4 academic and 1 international research institute, 3 SMEs, 4 international companies, 2 stakeholder-representing organisations and 1 international organisation of mixed academic/private members. With established cooperations, we will train doctoral students around three pillars: (i) Lipid biomarkers, artificial intelligence and disease modelling, (ii) Lipid-associated pathology & disease mechanisms, and (iii) Lipid application in clinics & industry. This will provide excellent scientific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Chemical (pyrolytic) and mechanical recycling of plastics and composites' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Foreseen ResultsA technical and economic evaluation of available pyrolytic processes;Development of a selective multi-stage pyrolysis process, compatible with current industrial developmentsMathematical modelling and upscaling to industrial conditionsModel calculation of the thermal decomposition processes of plastics in various pyrolyser unitsOptimization of working conditions (temperature, pressure, catalysts)Quality control of pyrolysis and mechanical recycling productsDevelopment of a pilot plantThree EU and two CCE countries start a collaboration to evaluate, test and further develop the practical knowledge on the pyrolysis of post-consumer plastic waste, including plastic and plastic/metal composite waste.In this proposal chemical (pyrolytic) and mechanical (compatibilizing) methods are tested for recycling plastics, especially mixtures and composites that cannot be reprocessed by simpler methods. The project is structured according to a number of tasks, each of which is tackled by a partner with previous experience in the field and aided by the entire team.Task 1 is basically a logistic, technical and economic evaluation of plastics recycling by pyrolytic methods.Task 2.1 is devoted to the effect on pyrolysis of providing mixed rather than individual plastic types, such as accelerated decomposition of PA 6 as a consequence of HCI-evolution from PVC. A major aim is the development and assessment of a process, in which a plastic mixture is decomposed sequentially, either as it is, or after addition of a catalytic substance.Task 2.2 systematically screens additives for their potential effect on rate and product composition, as well as on the generation of undesirable substances.Task 2.3 studies carbon formation from single and mixed plastics, its enhancement by spec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Global Engineering and Manufacturing in Enterprise Networks' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The project aims to create IT infrastructures and related tools to support globally distributed and dynamically networked operations in one-of-a-kind industries. By combining the views and requirements of various industries GLOBEMEN aims to guide and encourage the industry and IT vendors to develop and adopt improved IT infrastructures. The project aims to demonstrate functionalities that offer attractive market opportunities to IT vendors for product development to satisfy the needs of various industries world wide.The measurable and tangible objectives of GLOBEMEN project are to:(1) define industrial requirements and(2) compliant architectures for globally distributed product life cycle management, customer support, project and manufacturing management in the virtual enterprise,(3) implement proof of concept industrial prototypes,(4) demonstrate core features of the architecture, and(5) promote deployment by IT vendors, manufacturing industry, academia and standardisation.The main focus of GLOBEMEN is inter-enterprise integration and collaboration in a global setting. The project will develop generic approaches and models for global inter-enterprise networking and it will also demonstrate some of the key issues (possible bottle necks) in real industrial cases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'From discovery to scale up of cluster based electrolytes for Ultra-high energy storage flow batteries' in the context of a Horizon 2020 call.

assistant: **Objectives**

Large scale energy storage demands are set to increase dramatically during the next years due to the expansion of renewables. One of the most promising large-scale electrical storage technologies are Redox Flow Battery (RFB) systems, which can convert electrical energy to chemical energy and back again. Here the electrolyte is an electro-active species where the chemical energy is converted to electricity in a flow cell. RFBs can act as both batteries and a fuel generation device depending on the needs of the user, which is advantageous because they can be recharged without replacing the electro-active material. The vanadium RFB is a promising technology, but is critically limited by only being able to store one electron per species giving a low energy density (~20 W h kg-1) and poor stability restricting many applications. Using the artificial intelligence driven discovery system of the ERC Advanced Grant SMART-POM, we aimed at the discovery of new metal oxide molecular polyoxometalate (POM) clusters showing unexpected properties. For instance, we found a molecule that can store > 10 times more electrons reversibly than the vanadium RFB making these the molecules the most reduced molecules ever discovered. Here we want to make a major step in translating this ground-breaking outcome of SMART-POM from discovery of new clusters, to scale up so the molecule can be tested in a flow battery device set up.  The heart of any flow battery is the electron storage redox electrolyte. The more electrons the electrolyte can store reversibly the higher the energy density and we aim here to beat the state of the art by at least an order of magnitude aiming >1000 Wh L-1 (at this point applications in electric cars are possible). We will licence the technology with the University of Gl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Development of archival quality leather'.

assistant: **Innovation**

The chief objective of this project is to develop a tannery process for the production of consistent quality book binding leathers that not only meet the requirements of existing relevant National Standards for resistance to acidic atmospheric pollution but have the properties required by the binder For the attainment of this goal the following RTD tasks will be undertaken within the framework of this project: Current commercial book binding leathers will be evaluated, in order to establish how these leathers fail to meet the requirements of the binder Quality control testing procedures will be developed to define end-user requirements in an objective manner, understood be both the Tanner and the binder, applicable to binding leathers in general systematic investigation of Tannery processes for the production of currently commercial semi-alum archival quality leather will be undertaken. aiming their optimisation for the production of leathers of consistent archival quality Transfer of the innovative processes to Industrial scale production working with Tanneries, specifically selected for this purpose. Alternative organic tanning processes will be investigated at pilot plant scale and evaluated for the production of metal-free archival quality leather. aiming the minimisation of the environmental impact of leather processing in long term It will be a co-operative type of RTD project whereas the role of the SME proposers will be to carry out pilot and semi-industrial scale trials. undertake the development of a quality control/testing workscheme for the definition of end-user requirements and the evaluation of the leathers produced the optimisation. development and evaluation of the innovative tannery processes and materials products of this project, as applicable End-us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EEN-InnovationJouney PT' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The proposal presented by this consortium is a proposal based on the continuity of the work that has been provided within the framework of the EEN-Innovate Plus PT proposal, in 2019, and whose objectives remain and are intended to continue. It should be noted that during 2020/2021, we will  initiate new approaches to cope with the challenges posed by the EIC - European Innovation Council – “From Idea to Investment” - which the EEN- InnovationJourney PT now incorporate into this proposal, under the “Consultation of Enterprise Europe Network on the Work Programmes for 2020-2021 COSME and H2020 activities”.Considering the challenges of the EIC, in addition to the SME Instrument there will be new competition schedules to consider, from FTI - Fast Track Innovation and FET - Future and Emerging Technologies, which will require more expertise and tools to accompany companies benefiting from these programs, insofar as each addresses the needs of a particular community in the innovation ecosystem.The challenges posed will require new approaches to the team, and therefore the reinforcement of stakeholders and partners (e.g. Clusters, Financial Institutions, etc.) - creating greater synergies and converting the Network into a ""hub and spoke"". The envisaged outcome of this project in Portugal is to provide services to 179 SMEs in 2 years, giving priority to all the beneficiaries under the European Innovation Council - Horizon 2020 and its successors. The project will deliver “7-day service packages” to SMEs located in Portugal. The beneficiaries of EIC programs, SME Instrument, FET and FTI projects and its successors, will be supported by the partners, according to the geographical proximity of the companies. The KAM services will also cover the Portuguese Islands, Azores and Mad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Transparently Reconfigurable UbiquitouS Terminal'.

assistant: **Innovation**

Re-configurable Radio Systems and Networks will offer the next major leap forward in mobile and wireless communications, particularly in light of the many existing world-wide air interface standards and the expected wide range of future broadband mobile and personal communication systems. Clearly, re-configurable terminals will offer greatly enhanced flexibility to the end user, supporting all types of radio systems (e.g. paging to cellular, numerous wireless LAN deployments, terrestrial to satellite, peronal communications to broadcasting) as well as enabling the integration of many systems within the same platform. The TRUST project specifically addresses the development of re-configurable terminal platforms from both the 'user friendly prospective' as ell as the underlying enabling technologies.Objectives:The Primary Objective of the TRUST Project is to Realise the User Potential of Re-configurable Radio Systems".This gives rise to a number of secondary objectives which are:Understand the Users' Requirements from their perspective of the System:"The Terminal".Translate these Users' Requirements into Technology Requirements.Advance the Terminal and Network Technologies through Research and Innovation.Validate, Promote and Disseminate these Advancements and Technologies.Work description:The TRUST Project comprises two phases and five closely inter-related work packages, four of which are technical. The phases of the project are characterised by the definition of requirements, specification and its validation of derived concepts. The technical work packages cross the boundaries between the phases and ensure overall continuity.The main working fields of the project are:Evaluation of user need of the re-configurable platform as well as defining the requirements for the sy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of a therapeutic HPV vaccine via target epitope identification by mass spectrometry' (THERAVAC) under Seventh Framework.

assistant: **Objectives**

At least 20% of human malignancies are caused by consequences of persistent infections. High-risk human papillomavirus (HPV) types cause over 500.000 cancer cases per year, rendering HPV the #2 human carcinogen after tobacco. Infection-related tumors are attractive targets for cancer vaccination, as they provide the opportunity to target antigens that are immunological non-self. Vaccination can be prophylactic, inducing immune responses preventing infection in the first place, or therapeutic, stimulating the immune system into eradicating established disease. Prophylactic immunization against HPV has become the paradigm for cancer immunoprevention. Unfortunately, current HPV vaccines have no therapeutic effect on existing infections.Studies on spontaneously regressing HPV-induced lesions show that cell-mediated immune responses are crucial in clearing established HPV infection. Cytotoxic T cells (CTL) kill infected cells after recognizing viral epitopes presented on HLA molecules on the cell surface. There are hundreds of different HLA types, and a given epitope is only applicable for the fraction of patients with the relevant HLA molecule.This project will define a set of T cell epitopes that elicit CTL-mediated HPV protection in the entire population, by including epitopes for all HLA supertypes. The applicant has established a methodology of determining which viral epitopes are presented on target cells during her past mobility period in the US. HPV-transformed cells of various HLA backgrounds are analyzed by nanospray mass spectrometry. Identified peptides are tested for immunogenicity and the ability to induce CTL. From these tests, a minimal set of functional epitopes providing >95% population protection coverage is selected for vaccine formulation.The technology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Epixfab services specifically targeting (SME) industrial take-up of advanced silicon photonics' (SME).

assistant: **Concept**

ESSenTIAL will bring silicon photonics within reach of European small and medium sized enterprises, thereby building on the track record of the Silicon Photonics Platform ePIXfab (www.epixfab.eu) and its integration into Europractice. To this end, ESSenTIAL offers affordable access to standardized active and passive silicon photonic IC and packaging technology, a path from design to manufacturing and hands-on training.Based on a consortium of major research institutes with silicon photonics expertise, ESSenTIAL will reach out to European industry and will support them to evaluate silicon photonics in the context of concrete applications and markets. To ensure low-cost early access and scalability to manufacturing, the maturity of silicon photonic IC technology will be enhanced by setting up a library of generic devices, a level of process and device benchmarking and a well maintained design flow. For the first time, devices in a standard package will be offered to allow easy testing. Training on the IC and packaging services will be offered, including hands-on design training. Maturity, standardization and sustainability will be driven by a steadily growing user base, from Europe and elsewhere.ESSenTIAL will ensure that ePIXfab will keep Europe's lead in fabless silicon photonics and will turn it into and industry-relevant platform.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ethics in Mongolian and South-East Asian Science and Technology', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The main aim of the proposal is to introduce the concepts and issues surrounding ethics in science and technology in Mongolia and as a by-product, in the wider region of South-East Asia. Mongolia, along with other neighbouring countries, is at a crossroad of economic transition while its well-educated scientific human base is faced with a host of new ethical issues in modern technologies and their applications that they are little prepared to deal with.The proposed workshop will provide a unique chance to analyse and debate these issues while learning from the experience gathered in Europe and elsewhere in developing economies. A group of experts representing a wide disciplinary and geographical experience related to the subject will provide input in the process of kick-starting a national debate on ethics in science and technology in Mongolia.A main output of this debate will be concrete policy recommendations for an ethics in science action plan that could be included in the forthcoming Mongolian national science and technology strategy. The active participation in this debate of other South-East Asian countries will also form a starting point for similar debates in the wider region as well as similar national initiatives.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Pharmacology of Metabotropic Glutamate Receptors : Their Role in Physiology and Pathology' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

To examine the role of each metabotropic glutamate receptor (mGluR) subtype in physiology To examine the role of each mGluR subtype in selected neuropathological models . To develop selective agonists and antagonists of mGluRs.Functional properties of neuronal populations expressing diverse mGluR subtypes will be studied by utilising electrophysiological, biochemical and anatomical techniques. The presynaptic mechanisms whereby mGluR subtypes control neurotransmitter release or the activity of ligand-gated or voltage-operated channels will be evaluated. Molecular biology studies with mGluR chimeras or transfected cells expressing mGluRs will identify critical domains responsible for their specific properties. Finally, attempts to correlate electrophysiological observations with behavioural tasks will also be performed.Gene expression, pharmacology and electrophysiology of mGluRs will be studied in models of cerebral ischemia in vitro and in vivo and in epilepsy. Behavioural (motor and learning), electrophysiological and biochemical abnormalities will be evaluated in transgenic mice lacking specific mGluRs and in animals treated with antisense oligonucleotides directed against mGluR mRNAs or with selective mGluR subtype antagonists, when developed. We expect to clarify the role played by mGluRs in these pathologies, and whether their activation or blockade might become potentially useful in clinical practice.Preliminary experiments indicate that aminoindane dicarboxylates (conformationally restricted analogues of phenylglycines) may selectively interact with mGluR subtypes with IC50S in the micromolar range. These compounds were synthesised and patented by three groups participating in this Project and they will be made available to other groups and tested. Since a highe