RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Holistically Optimised Logistics Operations and Green Innovative Solutions for Transport Cargo Sustainably'.

assistant: **Concept**

HOLGISTICS will pilot and demonstrate innovative open standard logistics solutions and technologies which accelerate freight transport decarbonisation while increasing operational efficiency and flexibility, ensuring logistics networks are cost effective and competitive, taking account of externalities. The project will scale up collaborative solutions for multimodal logistics nodes and networks, enhancing digital and physical interoperability, supported by effective business and governance models, and facilitating increased use of zero emission vehicles and vessels. This will lead to major reductions in GHG emissions in the logistics networks, supporting the 2030 Climate Target Plan to reduce emissions by 55%. Logistics supply chain performance will be further improved via a Physical Internet approach, synchromodality and models which drive pooling, resource sharing and optimisation of capacity utilisation across modes.A wide range of processes, procedures and services in multiple logistics nodes and operations across Europe will be implemented, enhancing innovations and technologies developed in previous Horizon projects, and magnifying the benefits of ongoing CEF investments. These include: AI, IoT, synchromodal logistics algorithms, interoperability using shared standardised boxes/containers, automation and autonomous systems, new business models and solutions for increased use of zero emission transport, semantic models for collaborative data sharing, Digital Twins, advanced simulation and visualisation solutions, resource sharing and pooled logistics models and innovative inventory strategies that enable increased use of greener transport. Open access definition and seamless interaction will be prioritised, enabling all players including SMEs to participate, explo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Hybrid Molecule-Nanocrystal Assemblies for Photonic and Electronic Sensing Applications'.

assistant: **Objectives**

Functional organic molecules and metal and semiconductor nanocrystals represent attractive building blocks due to their composition-, size- and structure-dependent electronic properties, and the ability to design and manipulate these properties via low-cost and established chemical synthesis. Building from the pressing need of the European market to develop novel, scalable and cheaper technologies for sensing applications, the main objective of the HYSENS project is to exploit inexpensive organic functional molecules and inorganic nanocrystals as building blocks to synthesize novel high-knowledge materials for the development of sensors for Group I, II transition metal cations and anions (Cl-, NO3-). The hybrid material intelligence resulting from the engineered combination of individual units will allow the execution of logic functions able to reduce false sensing outputs towards the development of sensors with enhanced selectivity and sensitivity. Our goal is to elucidate the mechanisms governing the optical and electrical response of such engineered hybrid materials arising from the interaction between the organic functional molecule component and the inorganic nanocrystal core component. Establishment of component-function relationships will lead to disruptive new knowledge that will impact on optical and electrical sensors technologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantum Unique Ergodicity and Random Waves on Graphs' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The proposal aims to address two important conjectures of Quantum Chaos,  Quantum Unique Ergodicity and the Random Wave hypothesis, via the analysis of eigenfunctions of the Laplacian on discrete graphs. It will provide a better understanding of two difficult problems of mathematical physics through an original approach, while developing spectral theory on graphs. The latter has a strong potential of applications in the study of networks, whose understanding is of great importance in the modern world. The expertise of the experienced researcher on analysis on graphs will be ideally complemented by the quantum chaos and ergodic theory specialists of the University of Bristol, to ensure the success of this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Optimising Radiomics for MRI-based personalised cancer treatment' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Although cancer survival rates have substantially improved in recent years, cancer is still among the leading causes of morbidity and mortality worldwide. The future of cancer treatment lies in early and better diagnosis and individually tailored treatments (‘personalised medicine). ptTheragnostic, a company dedicated to the development of more effective, individualised therapies for cancer patients, is working on a breakthrough solution, Radiomics, that is able to revolutionise personalised cancer treatment. Radiomics is a quantitative image analysis technology that enables patient stratification through the use of routinely acquired biomarkers. Being based on the evolution of hundreds of image-derived features over the course of treatment, Radiomics allows for more sensitive and robust identification of tumour types than currently possible. As MRI is recognised as one of the most promising techniques for the detection of cancer and spread of the disease, ptTheragnostic aims to align Radiomics with MRI. Despite the availability of a multi-disciplinary team at ptTheragnostic, they lack the required expertise and skills to implement Radiomics in the MRI market. Therefore, the goal of this project, REACT, is to hire a skilled associate with expertise in MRI and deep learning to establish this implementation. During the first 12 months, the associate will be responsible for managing the designed innovation track of Radiomics. This includes both technical and business tasks, amongst aligning the Radiomics software with MRI scanners and drafting a marketing strategy for Radiomics. The associate will follow various trainings in the oncology and business field. REACT may therefore open up new career possibilities in both the business and academic (oncology) field. In addition,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NOVEL MECHANISMS INACTIVATING CHECKPOINT RESPONSE' (CHECKPOINT-INACT), addressing dissemination and exploitation.

assistant: **Impact**

Eukaryotic cells need to preserve the integrity of their genomes. Conditions resulting in increased genome instability, defined as the generation and amplification of mutations and chromosomal aberrations, are associated with cancer predisposition and human pathologies. The DNA damage checkpoint acts as a surveillance mechanism that safeguards genome integrity in response to genotoxic insults. While the processes leading to DNA damage checkpoint activation have been extensively studied, little is known about mechanisms mediating its inactivation, which is essential to restore normal cell physiology and overcome genotoxic insults.A genome-wide genetic screen performed by the research group identified novel Checkpoint Inactivating Factors (CIFs). These have been implicated in inactivation via proteolysis and subcellular sorting of several substrates but were previously not been implicated in the checkpoint response. Noteworthy, human orthologs of these factors have been involved in malignant transformation and cancer development.In this project genetic, genomic, molecular biology and proteomic approaches will be used to characterize the role of these novel CIFs in the cellular response to genotoxic insults. The project also aims at identifying and characterizing CFI’s targets within the checkpoint pathway. The research proposed will contribute to elucidate how eukaryotic cells revert checkpoint activation to maintain genome integrity, thus providing a framework for the development of new therapeutic agents.CIG funding will be invested in human resource in order to boost the project’s efficacy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Industry host fellowship in modelling for water applications' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Development of Global Computer Aided Process tools and Local Computational Fluid Dynamics models for wastewater treatment processes. Coupling of hydraulics and process characteristics, to improve diagnostic tools, design and operational layout and understanding of short and long term performance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Optimum design of multibody systems' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The aim of the project is to develop a complete set of advanced software tools for the optimal kinematic and dynamic design of multi-body systems (MBS) using high-performance, parallel computers. These tools are intended for use in design and industrial production environments relevant to mechanical engineering.The main objectives of the project are: - To develop software modules for kinematic synthesis and optimum dynamic design of MBS using HPCN, linked to a parametric and variational interactive CAD modeller.- An interactive interface for the definition of design variables, geometry and objective functions.- To implement and run the most time-consuming tasks in an HPCN environment making use of multi-CPU computers and clusters of workstations. The starting point for this project will be the CAD and MBS-simulation packages currently available within the consortium. These will be enhanced with additional capabilities that will allow the new modules developed in this project to run in the same environment. The use of standards such as UNIX, C++, X-Windows, Motif and STEP and a modular structure, based on Object Oriented Programming techniques, will guarantee the openness, portability and scalability of the system. The consortium will exploit the software developed both internally and externally. http://www.ceit.es
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Transcatheter Ventricular Repair Device for treatment of Heart Failure Patients' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Heart failure (HF) represents a major public health concern, affecting around 13M people worldwide. A major risk factor for HF is a myocardial infarction, which causes ventricular remodelling, during which the ventricle enlarges, making the heart even less effective at pumping blood, and        results in displacement of the papillary muscle. Progressive papillary muscle displacement leads to severe Functional Mitral Regurgitation in about 20% of the patients, the only ones currently receiving treatment because of the severity of the condition. The remaining 80% of patients don’t        experience severe FMR and are not considered for surgery: they will continue to suffer, and likely die since there is no therapeutic option available. Cardiac Success develops the V-sling system, a transcatheter ventricular repair device to improve cardiac function in HF patients. The        objectives of the project are to finalize product optimization, complete V&V and pre-clinical testing, and perform the FIH study.


**Keywords:** Heart, Heart failure, Transcatheter procedure, Hospitals, Implant, Papillary muscle sling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mechanisms and functional significance of diffusion barriers  for asymmetric segregation of age in neural stem cells' to be submitted under Horizon 2020.

assistant: **Abstract**

Neural stem/progenitor cells (NSPCs) continue to generate new neurons throughout life in distinct regions of the mammalian brain. Adult neurogenesis has been implicated in brain function and altered neurogenesis has been associated with a number of neuropsychiatric diseases such as depression and cognitive ageing. A key feature of somatic stem cell division is the ability to divide asymmetrically and symmetrically for neurogenic and self-renewing cell division, respectively. However, it remains unknown how age is segregated in the context of somatic stem cell division, i.e., if the cellular history and the replicative age of the mother stem cell is passed onto its progeny. Thus, we hypothesized that – similar to the previously described barrier that exists in budding yeast – somatic stem cells, and more specifically NSPCs, form a diffusion barrier during cell division to retain aging or senescence factors within the stem cell, generating a mechanism for how age is asymmetrically distributed. Indeed, we found the existence of a diffusion barrier that is established during NSPC division, identifying a new mechanism of cellular segregation and asymmetry. With the program proposed here I aim i) to study the effects of the barrier on asymmetric segregation of aging factors and to develop novel tools to visualize the mammalian diffusion barrier, ii) to characterize the presence of a diffusion barrier in endogenous NSPCs in relation to cell division history, iii) to analyse the mechanisms underlying age-associated weakening of the NSPC diffusion barrier, and iv) to evaluate if genetic and pharmacological rescue of the barrier is sufficient to ameliorate the age-dependent decline of neurogenesis. The insights gained from the studies proposed here have the potential to substanti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Production of renewable methanol from captured emissions and renewable energy sources, for its utilisation for clean fuel production and green consumer goods' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Headquartered in Reykjavik, Iceland, Carbon Recycling International (CRI) is the world leader in power to methanol technology. The company has accumulated a decade of experience in solving the problems of economical CO2 capture and valorisation as well as reliable and cost effective large-scale production of hydrogen by electrolysis. CRI invented a new integrated process for sustainable low-carbon intensity fuel production. CRI’s Emissions-to-Liquids (ETL) technology has been scaled up from a laboratory scale pilot to an operating industrial scale plant with a capacity of 4,000 tons/year methanol production. Low carbon intensity methanol production with CRI technology reduces carbon emissions by more than 90% compared to fossil fuels. ETL is a sustainable process of renewable fuel production which has no impact on our food chain or land use. Methanol produced by CRI can also be directly used in the chemical industry for the manufacturing of sustainable goods such as paints and plastics.CRI aims to up-scale its current plant scale and offer a standard, modular ETL plant design with nominal 50.000 t/yr methanol production capacity. The improved ETL technology achieved with the current innovation project, will enable CRI to efficiently operate using variable power sources or stranded energy assets. One of the defining characteristics of renewable power sources such as wind and solar is their interment and variable production levels. High capacity factor production sites are often untapped or under-utilized due to the lack of adequate transmission line access or capacity. CRI will provide a means to valorise under utilized renewable energy sources.Our mission is that by 2022 in total 1million tn/yr methanol capacity is commissioned. This corresponds to 1.45 million tonnes o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Topological structures for periodic orbits of graph maps via suspension' (1994-1998).

assistant: **Innovation**

Research objectives and content The proposed research programmeis to understand some structures for the set of periodic orbits for continuous maps of a graph into itself. The goal is to give a general framework where all the previously known cases would be included. Some particular cases have been intensively studied '` la Sharkovskii', such as the interval circle and tree maps. The case of surface homeomorphisms has been treated via special graph maps and should also be a particular case. The new ingredient in this programmeis to consider graph maps via the 'suspension operation' for which I gave a combinatorial construction in my PhD thesis. This operation gives at the same time a 2-dimensional complex and a semi-flow. A periodic orbit of a graph map gives rise to both an element of the fundamental group of this complex and a periodic orbit of the semi-flow. The initial dynamical problem can then be studied by standard Algebraic technics and, for instance, a generalization of the notion of 'braid type' is expected. Training content (objective, benel it and expected impact) Barcelona is a perfect place for such a programmeto be developped since the dynamical system group is very active, as well as the Algebraic topology group.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'KNOwledge from Science to SOcitieS' (KNOSSOS).

assistant: **Concept**

KNOSSOS seeks to address the gap between science and society in the field of environmental research with a focus on policy makers and civil society, who are the main recipients of the project. We propose to take stock of available research results that are useful for policy-making. KNOSSOS will then add a knowledge management system, with innovative tools to guarantee fast and easy access to relevant information. This initial phase will also yield collaborative workshops on evidence-based policy making and training for policy makers in the field of environmental research. KNOSSOS puts an emphasis on disseminating research findings beyond Europe: through a number of ‘Knowledge Fairs’ as side events of international conferences, but also by including DG Research findings in one of the world’s largest collections of Environmental Science Research, the Online Access to Research in the Environment (OARE). In order to ensure swift uptake of European environmental research into policy making, KNOSSOS, with its partner IEEP, the Institute for European Environmental Policy, will issue monthly policy briefs for European, national and international policy makers. Aiming for enhanced visibility of European mission to raise public awareness about emerging environmental issues. KNOSSOS’ strength lies in the composition of its consortium: UNEP, the world’s leading environmental authority, joins forces with the Institute for European Environmental Policy, a renowned independent not-for-profit institute with a strong reputation in giving policy advice; and with GLOBE EU/Europe, an excellent partner in training policy-makers and disseminating deliverables. KNOSSOS will have an impact on both policy makers and civil society in and beyond Europe. Our goal is to make European environmental