RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Novel antigens for human gamma delta T cells'.

assistant: **Concept**

T lymphocytes bearing gamma delta T cell receptors (TCR) make crucial contributions to tissue-surveillance of infection and non-microbial stress. Although these cells may recognise dysregulated tissues via their activating NKG2D receptor, we remain very ignorant of stress-related molecules that may bind the gamma/delta TCR directly. Much work has focussed on peripheral blood gamma delta T cells expressing Vgamma9-Vdelta2 TCRs. Recently however, several Vgamma9-Vdelta2-negative clones were isolated which react both to cytomegalovirus-infected cells and to colonic tumours. This has led to the identification of Endothelial cell Protein C Receptor (EPCR) as a TCR target of one such clone. This is only the third gamma delta TCR ligand validated biochemically. I shall now assess the generality of EPCR reactivity among human gamma delta T cells. Using ELISpot technology, I can apply a very sensitive means to investigate cytokine production by gamma delta T cells from cells of donors of various ages and health status. Moreover, since EPCR is strongly conserved, I shall extend the project to mouse. The identification of EPCR activity in mice would substantially enhance the capacity to dissect the biology of this novel response. Finally, I shall also investigate candidate ligands for aVgamma9-Vdelta2-negative clone that does not bind EPCR.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ENRICH: EC-ChiNa Research Network on Integrated Container Supply CHains' (ENRICH).

assistant: **Concept**

The overall aim of this proposed exchange programme “ENRICH” is to bring together an international team of researchers to establish a research network, with a wide variety of skills in operations research, safety and security studies, green logistics, economic modelling, ICT, and intermodal management to develop a container supply chain (CSC) integration methodology, aimed at addressing long-lasting changes in operational, environmental, economic, technical and managerial practices in different segments of the rail, road, air and sea transport industries from an overall supply chain perspective. The network is a physical and virtual grouping of academics and researchers designed to create an interdisciplinary think-tank and knowledge exchange platform for enhancing CSC resilience and sustainability in today’s and tomorrow's operational environments, in which a high level of uncertainty exists due to economic crisis, security risks, climate change, and every changing technologies. The proposal is for a project of eight partners (5 EU members, 1 AC member and 2 Third Country members) with extensive exchange of both experienced researchers (ERs) and early stage researchers (ESRs) during four years to fully explore the complementary strengths and synergies within the consortium. This project will support and reinforce the collaborations amongst the participants and help establish a long-term research co-operation. The research will increase the European research capacity in this vital and rapidly developing container transportation field, and also maintain and enhance the EU’s leading position in the areas of supply chain resilience and sustainability. Moreover, the interdisciplinary nature of the proposed exchange programme offers a link for research and training of the in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Manufacturing process for bio-based fibre-reinforced composite parts for structural applications' (BioStruct).

assistant: **Concept**

Currently, the use of bio-composites is limited to less critical applications that do not have significant requirements in terms of mechanical performance. However, the use of synthetic composites made from carbon or glass fibre has several difficulties in terms recycling and in terms of dependence on third countries. About 98% of these synthetic composites still end up in landfills and about 80% of the raw materials are currently manufactured outside of Europe. To improve this situation, the project addresses the challenges of using bio-composites for structural parts and aims to increase the range of applications in which bio-composites can be used. This will be achieved by developing an accurate draping process to control fibre orientation, by creating material models that capture the natural variability of the material and by integrating nano-structured, bio-based sensors for load monitoring. Through the increased accuracy and additional control loops in the manufacturing process the consortium expects to achieve predictable properties and constant quality.Within the project use cases from wind energy and boat-building will be investigated, aiming at the manufacturing of a full size rotor blade and a ship hull to demonstrate the technical feasibility and achieving TRL7 for the manufacturing technologies. In addition to the end users, the consortium consists of partners from automation, machine building, measurement technology, material manufacturing and simulation software to cover all aspects of the developments. Based on the predicted growth of the bio-composites market, which is expected to increase by a factor of 2.5 by 2030, the consortium expects a market potential of about 100M€ by 2030.


**Keywords:** bio-composites, draping, material models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Processes in large-scale circulating fluidized bed combustors ('CFB COMBUSTORS')'.

assistant: **Innovation**

Objectives and problems to be solved:The purpose of this project is to assess the hitherto insufficiently known features of large scale circulating fluidised bed (CFB) combustors. The aim is to provide data for reliable operation and scale-up under the condition of high efficiency for electricity production and high reliability. The environmental consideration, low emissions of unburned matter, nitrogen and sulphur oxides, forms the background for the entire work. Another important reason for the investigation is that the CFB technique is new and almost no information is available on the detailed processes within a full scale CFB-furnace, except for data from laboratory and pilot scale plants: Thus, more data are needed. Description of work: The method of work is to explore the operational properties of a selected large scale (several hundred MW electric power) CFB and to extend measurements previously made in laboratory and pilot scale equipment (whose height is in the order of 10 m) to the scale of the large commercial boiler which has a height of the order of 40 m and a cross-section of a few hundred square meters. The quantities which are studied include: · hydrodynamic properties such as solids concentration, solids flux and boundary layers in the combustion chamber· characteristics of the combustion process; temperatures, gas concentrations and air-fuel mixing. · all boiler parameters under different steady state and dynamical conditions. To obtain these quantities field measurements on site in an existing power station are required. These measurements are carried out on a CFB boiler, which has recently been put into operation. The boiler is one of the largest in the world. In a preparatory phase holes are made in the boiler walls and measurement probes are manufa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Functional oxide structures for advanced microwave systems (FOAMS)'.

assistant: **Innovation**

Microwave systems play a key role for the global society of the next millennium with applications from terrestrial and satellite communication including software Radio, UMTS GPS and DBS TV to environmental monitoring from satellite and future systems connecting phone networks for car and aircraft navigation. Improved microwave components based on dedicated materials & new designs are required.The materials, combinations and structures to be investigated are the following :- dielectric ceramics & crystals with low loss at low temperature & R.T.- ferroelectric/superconductor heterostructures for electronic frequency tuning- photonic dielectric structures: high Q & tailored temperature coefficient.This project has successfully delivered on all the original objectives.1 High temperature superconducting filters with low insertion loss and steep filter skirts were developed and functionsl. Thin films of YBCO were successfully deposited by Pulsed laser deposition and by magnetron sputtering. Tuneable devices were made with ferroelectric SrTiO3 and (BaSr)TiO3.2 Ceramic development concentrated on the manufacture of ultra low loss alumina and a temperature stable Alumina-titania layered composite. This was extremely successful and has been patented. A demonstrator satellite filter has been constructed.3 Photonic structures are in the early stages of development.4 Phase noise measurements have been performed and intermodulation experiments have been conducted on the devices.5 A Cryogenic ultra stable microwave oscillator comprising sapphire and rutile has been successfully built and tested.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Data Process & Technological Bricks for expanding digital value creation in European Data Spaces' (DataBri-X) under Horizon Europe.

assistant: **Objectives**

The emergent European Data Economy relies on the availability of data as a basis for further innovation and exponential development of technologies, especially the development of trustworthy ‘made in Europe’ AI that reflects European values. Data Spaces, platforms and marketplaces are enablers, key to unleash the potential of such data. However, data sharing and data interoperability are still at their infancy. Through DataBri-X, European Data Spaces, platforms and marketplaces and their wide range of business, governmental and public, research and civil society stakeholders will be equipped with a holistic and flexible data governance process and a seamless integrated standards based toolbox for data- and metadata management which can be assembled along relevant requirements, provides open source as well as commercial tools (the bricks / bri-X), and mechanisms to load 3rd party resources like language resources or AI models, and can be easily deployed into Data Spaces and thereby will contribute to make Europe the most successful area in the world in terms of data sharing and data re-use, to gain the full benefit from the value of data, while respecting the legal framework relating to security and privacy. The project's objective is to provide a holistic, energy-efficient and user-friendly toolbox of practical, robust and scalable bricks/Bri-X (processes, technologies and tools) that improve the interoperability, usability, discoverability, quality, and integrity of data and metadata, with the aim of making data sets ready for expanded digital value creation in the context of European Data Spaces. The DataBri-X toolbox will be offered in compliance with accountability, fairness, privacy, and confidentiality regulations as well as FAIR principles and will build on exist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identification of specific interactions between the transcription factor e2f-6 and polycomb group proteins, and the role of distinct complex formation in transcriptional repression.', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

To identify specific E2F-6/Epc- 1L containing complexes by co-immunoprecipitation experiments in vitro and in vivo, and by purification of complexes through both affinity and gel filtration columns, and to characterise the role and biological importance of specific complexes in transcriptional repression.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multisystem imaging of whole-body emotion circuits with total-body positron emission tomography' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The goal of the TOTALBODY project is to establish the interacting biological networks supporting human emotions and their disorders across the brain and periphery using novel total-body positron emission tomography (PET) approach. The body-to-brain axis maps visceral signals onto emotions, driving complex motivated behaviours. Negative emotions are risk factors for cardiovascular diseases (CVDs) Conversely, CVDs are associated with anxiety, highlighting the link between negative emotions, bodily functions, and somatic health. Systems-level interaction between brain and peripheral organs could thus be a key pathway underlying psychiatric disorders, but it remains poorly understood. TOTALBODY tackles this question from ground-breaking viewpoint by implementing novel total-body PET approach for measuring the physiology of the emotion circuits across the brain and body, creating an innovative multisystem biology approach for studying emotions. We simultaneously map activity in the brain and peripheral organs during pharmacologically and psychologically induced emotions in a large sample (n=240) of healthy volunteers and patients with generalized anxiety disorder (GAD). Links between CVDs, GAD, and whole-body emotion circuit activation are mapped in a clinical study involving 300 patients with suspected CVD. The data are analysed using state-of-the art multi-organ modelling framework developed in the context of the project. Advanced pattern recognition techniques implemented on the whole dataset (540 subjects) are used for discerning the central-peripheral pathways associated with future onset of anxiety and CVD. Anxiety and CVDs constitute a major burden for health and well-being worldwide. This unique large-scale analysis of the central-peripheral axis of anxiety and cardi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Online Labour: The Construction of Labour Markets, Institutions and Movements on the Internet' (2014-2020) under Horizon 2020.

assistant: **Objectives**

World Bank, EC Joint Research Centre, and other bodies have recently highlighted the potential of online labour markets to boost employment and economic growth. While national job markets have stagnated, online labour markets that connect firms with knowledge and service workers around the world have grown up to 60% a year.An overlooked aspect of these markets is that they extricate workers and employers from national institutional frameworks, such as employment law and collective bargaining, and instead impose their own, technologically enforced institutions. For example, a leading marketplace recently instated a global minimum wage of 4.00 USD/h. With over 540,000 employers and 4,000,000 registered workers in 180 countries, this Californian company is making critical labour policy decisions that influence businesses and individuals from Berlin to Manila.The objective of this project is to lay bare the politics and institutions of these next-generation labour markets promoted with discourses of technological progress. Whose interests find expression in their institutions? Some online workers have begun to organize transnationally with the help of digital media. How do online labour movements emerge and assert power on these markets? And finally, to what extent are these relations still reducible to struggles between capital and labour, rather than more ambiguous networked models of production?We will tackle these questions through a combination of conventional social research methods and innovative Internet research methods, on both virtual research sites (online labour markets and workers' online communities) and physical research sites (market operators' premises and worker gatherings). We survey, interview, and observe designers and workers to reconstruct processes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The use of DNA and magnetic tracers to ensure quality and eliminate hazardous tampering and counterfeiting in the alcoholic drinks industry' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Background The counterfeiting of branded wine and spirit bottles and filling with inferior product, or the refilling of genuine bottles with inferior product, can have serious health implications for consumers. This fraudulent activity will have serious economic implications for the mainstream wine and spirit industry and affect income for national governments due to decreased tax revenues accruing from lower bona-fide sales.  Objectives The prime objective of this project is to develop devices which will provide additional quality assurance relating to the production and sale of alcoholic beverages by protecting them against adulteration and counterfeit products. These aims can be met by developing and applying DNA coded microspheres to labels and bottles. Once applied these items can be detected by inspection and identification and logistical information stored on the DNA coded microspheres can be decoded and used to enhance product security. In addition, a key element of the project, will be the development of a device and sensor which will indicate whether genuine bottles have been refilled and resealed.  Work programme The workprogramme has been divided into 4 workpackages. The first workpackage is concerned with evaluating the feasibility of adding and recovering DNA security tags from printing inks. The recovered tags will then be sequenced for decoding. The second workprogramme examines the application to and recovery and decoding of DNA security tags from etched and non-etched glass containers. The third workpackage is concerned with the development of a magnetic strip for incorporation into glass or non-glass container closures, the integrity of which determines whether the containers have been previously opened. The final workpackage will evaluate whether foo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Intelligent Live Cell Analysis [iLCA] to transform disease management through faster, and more regulatory robust, discovery, manufacture and monitoring of biologic drugs & cell therapies'.

assistant: **Objectives**

The detailed analysis of live cells, as shed elements of a human disease process, cell therapies themselves or as factories for the production of biologic drugs, is attracting intense focus globally from diverse companies in automation, imaging, diagnostics and manufacturing. This proposal is made on behalf of a consortium of 3 European SME’s to support the validation and preparation for commercial take-up of the market entry application, Cell Line Development [CLD], of a new transformative technology at the forefront of these areas and is ideally suited for cell line development, antibody discovery, gene editing, cell therapy, antibody engineering and ex-vivo diagnostic workflows. Each workflow provides a dramatic increase in insight, control, speed and cost, ultimately resulting in faster, cheaper and more regulatory robust medicines for European patients.   Biologic drugs are large in size and are manufactured from a single cell selected following an expensive, relatively crude and time consuming process - Cell Line Development. Our technology can select the 'Top' cell using a detailed analysis of the critical quality attributes along with providing complete image recording and documentation of the growth from a single cell [regulatory requirement]. This cell selection and control is essential as all resulting master and working cell banks are used over the entire life‐cycle of the marketed product that can last multiple decades.   This FTI funding will enable market entry and validation & support external fundraising for the wider penetration of the global drug discovery, Cell therapy & ex-vivo diagnostic markets. This is a potentially transformative technology platform in a very large market with 1 current aggressively funded US competitor and our success will ensu