RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Corticostriatal and Intrastriatal Neuronal Microcircuits Involved in Motor-Control' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The basal ganglia are a group of sub-cortical brain nuclei involved in motor related tasks such as motor planning, selection, and execution, as well as in a variety of cognitive functions such as attention and memory. Malfunctions of basal ganglia are related to diseases and disorders such as Parkinson's disease, Huntington disease, Tourette's syndrome, and others.The input layer of the basal ganglia is the striatum, consisting mainly of GABAergic spiny neurons, which project to the other basal ganglia nuclei via direct and indirect pathways. These pathways are believed to be crucial for selection and execution of motor tasks. The striatum receives most of its excitatory input from various cortical areas, via the corticostriatal pathway. Despite the vast anatomical knowledge of the striatum and the corticostriatal pathway, little is known about the intrastriatal and corticostriatal microcircuit properties. In this study I will use multi-neuron patch-clamp recordings combined with retrograde fluorescent labelling, morphological 3D reconstruction and single-cell RT-PCR, to obtain a detailed description of the electrophysiological, morphological, and synaptic properties of the intrastriatal and corticostriatal microcircuitry.The aim of this study is to obtain fundamentally new insights about the functional organization of the striatum and its cortical afferents, and the way they participate in motor control and selection of behaviour. The study will therefore also have direct bearing on the understanding of basal ganglia-related disorders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Physiological impact of IF1 inhibitor on Reverse Cholesterol Transport (RCT) and atherosclerosis' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Several large prospective studies established that high-density lipoprotein cholesterol (HDL-C) is an independent negative risk factor for CHD thus representing today’s major protective factor against atherosclerosis, mostly attributable to their roles in ‘Reverse Cholesterol Transport (RCT)’. RCT allows excessive cell cholesterol to be taken up and processed in HDL particles, and later carried to the liver. To identify new cellular partners involved in hepatic HDL-C clearance in human, Martinez et al. recently reported the presence on the cell surface of human hepatocytes of a complex related to the mitochondrial ATP synthase as a high affinity receptor for HDL apolipoprotein A-1. This complex is involved in a cell surface signalization pathway for HDL endocytosis in which apoA-1 binding to the ATP synthase (ectoF1-ATPase) stimulates extracellular ATP hydrolysis into ADP. The newly synthesized ADP specially activates the nucleotide receptor P2Y13 resulting in clathrin-dependent HDL-C endocytosis. P2Y13 deficiency in mice (P2Y13 knock out/Ko) provokes a significant decay in biliary lipids secretions. Studies on P2Y13 Ko mice on atherosclerotic background (apoE Ko) showed that double Ko mice displayed an increased atherosclerosis plaque, compared to apoE-Ko. We aim to study whether regulating the ‘F1-ATPase/ P2Y13’-mediated HDL endocytosis pathway might be a therapeutic target in prevention and treatment of atherosclerosis. The F1-ATPase Inhibitor IF1 (inhibitor factor 1) is a10 KD protein that was shown to inhibit HDL uptake both on human hepatocytes and in situ on perfused rat liver. IF1 was found to be constitutively expressed at the hepatocyte surface, suggesting IF1 physiological role in inhibiting hepatic HDL endocytosis. However, very little is known on the physio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Representation in Legal Proceedings' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Litigation in person is a widespread phenomenon in common law jurisdictions. A right to litigate in person is treated as a fundamental right in both civil and criminal proceedings, regardless of whether the litigant or the defendant has the financial means to hire a lawyer or the capacity to conduct litigation effectively. The proposed research has two primary objectives. First, to establish a general principle that the right to self-representation has no significant theoretical value and, accordingly, that it is justifiable to require legal representation in cases where litigants in person are unlikely to be able to litigate their cases effectively and without imposing disproportionate costs on the administration of justice. The second objective is to explore the specific conditions under which the general principle set forth above should be applied, and the types of cases in which mandatory representation may or may not be justifiable. The theoretical part of the project will be developed on three main fronts: a comparison of the civil and criminal contexts; an assessment of the value of self-representation in terms of outcome, including a cost-benefit analysis; an examination of the possible intrinsic justifications of self-representation, with particular emphasis on personal autonomy, litigants’ subjective satisfaction and their acceptability of adverse outcomes, and the entitlement of citizens in a democracy to participate in a process that is decisive to their interest.  The theoretical findings will be utilised to conduct a detailed doctrinal analysis of the case law of English and American courts, and also that of the European Court of Human Rights, the European Commission on Human Rights, the International Criminal Tribunal for the former Yugoslavia, and the Un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Colloidal delivery systems for phytochemicals; Ayurveda' (AYURVEDA), addressing dissemination and exploitation.

assistant: **Impact**

Ayurveda medicaments composed of herbs or mixtures of herbs is one of the world oldest medical systems. The medicinal value of herbs comes from the natural bioactive molecules collectively known as phytochemicals. Phytochemicals are diverse in nature and they have multiple applications and can be used as a pharmaceutical, nutraceutical and cosmeceutical. Although thousands of phytochemicals have been identified and many of their benefits have already been proven,ayurvedic medications have lagged far behind in becoming a well-accepted medical & health care system. Also, the diverse potentials of ayurvedic actives haven’t been exploited completely by the food and personal care industries. The main reason for this is the challenge involved in formulating phytochemicals into complex product matrixes, which can enable their effective delivery and keep the product stable. Recent advances in colloidal science and technology have introduced modern techniques, which could be applied for designing of effective delivery systems. Thus, the present research will be aimed at applying the principles of colloidal science for structuring and delivery of phytochemicals in different product formats. The particle size, composition, morphology, and surface properties will be controlled through proper fabrication approaches. The behaviour (aggregation,assembly) of these particles will be studied in relation to bioavailability and product stability. Here, for the first time, we will apply an integrated approach where nutritional, formulation, stability, and organoleptic aspects will be considered on the basis of their origin–the physico-chemical and colloidal properties of the individual ingredients. The research will be undertaken to exploit untapped potentials of ayurvedic actives by introd
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Depolymerisation, Polymerisation and Applications of Biosustainable Raw Materials for Industrial Polymeric End Uses'.

assistant: **Concept**

Objectives and content The European Chemical Industry has always been a major contributor to the health and prosperity of the European Industrial base and accounted for just greater than 2% of the West European GDP. The European chemical industry accounts for 11.5% of manufacturing turnover 10% of value added and almost 8% of the manufacturing workforce (CEFIC data for 1993). At present this industry is heavily dependent on non-renewable petroleum based feed stocks which are becoming increasingly scarce and expensive. Alternative feed-stocks could be provided from renewable bio- materials such as carbohydrates from sources such as wood, straw, potatoes corn etc. which are freely available within Europe. Products derived from these raw materials offer advantages in the following areas: - Environmental - The use of renewable biodegradable raw materials, minimisation of pollution from petroleum feed-stocks - Economic - Potentially a lower cost - Technological - Potential for novel improved formulations The chemistry of carbohydrates offers great potential for novel and innovative products. - Social - The use of European sourced biosustainable raw materials would have positive effects on employment in the agricultural sector. It is the objective of the project to evaluate new applications for three important, abundant types of carbohydrates -starches, celluloses and hemicelluloses. The native" materials will be obtained, characterised and then modified either chemically, physically or enzymatically to produce a range of new bio- material "building blocks" . These will then be subject to further treatment such as polymerisation to yield materials suitable for advanced polymeric applications. The project will aim to draw generic conclusions about the potential of the resultin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Hybrid Bead Adsorbents'.

assistant: **Innovation**

Each year, millions of people, most of them children, die from diseases associated with inadequate water supply, sanitation and hygiene. In particular, exposure to heavy metals in drinking water, even at trace levels, poses a considerable health risk. As included in one of the seventeen sustainable development goals of the United Nations, “safe water and adequate sanitation are indispensable for healthy ecosystems, reducing poverty, and achieving inclusive growth, social well-being and sustainable livelihoods”. In this PoC project, named Hybrid Bead Adsorbents (Hybead), we aim to evaluate the feasibility of advancing Hybrid Inorganic Nanoparticle/Metal-Organic Frameworks Bead-type adsorbents into the pre-commercial stage, with the aim of accelerating their access to the market as an efficient technology for removing heavy metal ions from water. The first part of Hybead encompasses scaling-up of our current spray-drying synthesis of these beads from the gram-scale to economically viable kilogram-scale production. We will also shape the composite beads for proving its use into existing water purification technologies. This will entail shaping Hybead into granules and integrating them as fillers into polymer matrices to produce membranes by common industrial-scale methods (e.g. compaction and solvent casting). The second part of Hybead will be dedicated to intellectual property (IP) and market aspects needed for the pre-commercialization of this new technology for water purification. This study will include a patentability study, a freedom-to-operate (FTO) analysis and a market study to identify the filter producers that could ultimately serve as manufacturing partners.In this project we will endeavor to assess the commercial viability of with Hybead adsorbents, accelerate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Matching Transoceanic Biotech Opportunities' (TRANSBIO), addressing dissemination and exploitation.

assistant: **Impact**

Biotechnology in Europe suffers from the European paradox: there are many hot spots of excellent research, but this new knowledge is not yet consistently being harnessed to create innovative products and services to enable European companies to take the le ad in what will become a key to future competitiveness, nor to allow European citizens to benefit from the quality of life advances that biotech will bring with it. The objective of TRANSBIO is to demonstrate to policy makers how EU companies and research institutions who perceive insurmountable barriers to participating in the global market can be successfully supported and encouraged to take their knowledge to the USA and Canada, attract development partners into their consortium and develop their ideas and innovations further in the world's most advanced and competitive markets for biotech products and services. To attract partners into joint development agreements in USA and Canada we recognise that we will have to provide an outstanding portfolio of offers. Therefore, we have designed the TRANSBIO project in such a way that only the very best and most promising joint European technology offers are included. We are also putting a high priority on working with teams trying to exploit knowledge created i n the EC's Framework Programmes to extract more value from the years of investment that have been made in this sector. Only by selecting, refining and actively promoting ideas that are taken up by North American stakeholders will we learn how to overcome t he legal, ethical and cultural differences which prevent successful transnational technology Transfer (TTT). Only from a group of success cases will EU policy makers and TT professionals learn how to do TTT in this complex and competitive environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Light-reconfigurable substrate for cell cultures', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

L-Cell is a method for robust, reconfigurable control of surface topography, based on creating reversible light-induced surface structures onto azobenzene-containing bilayers. These light-reconfigurable substrates allow free-form topographical patterns to be created and subsequently erased over many cycles on a biocompatible cell culture substrate, even when the cells are already growing on the substrate. L-Cell aims at mimicking more closely the dynamic conditions in human body, which regulate many physiological and pathological processes, such as tissue morphogenesis, healing, and tumour growth. Our non-invasive solution is important for definition of chrono-programmes e.g. cell differentiation, stem cell phenotype harvesting, tissue regeneration and triggering cell directional migration. The bilayer structure allows for easy chemical modification of the surface, ensuring biocompatibility and further functionalization, and fully supporting existing protein deposition techniques. L-Cell reconfigurable light-responsive petri dishes can be used as drop-in solution, enabling new, unique biological investigations on cell dynamics to be conducted. Besides, the growing need to reduce animal testing in drug screening, toxicology, and research has increased the demand for innovative cell culture solutions that recapitulate the complexity of cell dynamics in a controllable, cost-effective way, without sacrificing their clinical relevance. For all these reasons, L-Cell offers new opportunities as an innovative tool for a wealth of potential targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Soundscapes of Trauma: Music, Sound and the Ethics of Witnessing' (MUTE) targeting Horizon 2020.

assistant: **Abstract**

MUTE’s main objective is to investigate for the first time empirically and theoretically the use of music and sound in situations of confinement and displacement from the Cold War to contemporary times. It explores their weaponization in light of transnational developments in technologies of terror. At the same time, it carefully attends to how music/sound can become a tool of survival, even in the same setting in which they are weaponized. Also explored are ethical challenges of such research, and of music programmes for prisoners and refugees, highlighting their shortcomings and providing alternative models. MUTE innovates through a theoretical framework that investigates the interlocking of politics, ethics, and aesthetics, focusing on the ethics of sound and ethics of witnessing. Its comparative approach extends to (post)colonial Cyprus, Greece, Serbia, Germany, Soviet Union and contemporary Russia, Iraq, Argentina, Chile, Uruguay and Paraguay. MUTE will critically analyse this complex phenomenon across the disciplines of (ethno)musicology, social anthropology, history, critical theory, human rights law and sound art, since it cannot be fully grasped through the methods of any one alone. The PI’s extensive immersion into all disciplinary components over the last decade, evident in her novel approach, ensures the successful implementation of research objectives. MUTE’s findings and results will transform scientific discourse, changing current perceptions about music’s social function. This historical recovery is important in revisiting and assessing detention-related policies and current definitions of torture. Given recent mass asylum seeking in Europe and the growing number of music research projects with refugees, it will offer the needed ethical, methodological a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Reprogramming of Tumor Stroma to Enhance Cancer Immunotherapy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Cancer immunotherapies have shown impressive success in cancer treatment. However, these therapies are limited to certain type of cancers, and success rate is still low. In particular, certain types of solid tumors containing an abundant stroma, which represent a majority of epithelial derived cancer, respond very poorly to immunotherapies. In these tumors, a major challenge for the development of novel cancer immunotherapies is represented by the tumor microenvironment (TME), a highly hypoxic and immunosuppressive environment which prevents proper tumor infiltration and functioning of effector immune cells. Recent discoveries identified tumor-activated mesenchymal stromal cells (MSCs) developing within the TME, and showed that they represent a major brake for efficient antitumor immunity in solid tumors. In this project, we will investigate the potential of a novel approach and therapeutic avenue to target specific populations of MSCs within the TME, and determine the synergistic effect with immunotherapies to improve treatment efficacy in solid tumors. In the long term, this project aims at overcoming a major barrier in utilizing cancer immunotherapies in solid tumors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Berlin neutron scattering center (BENSC)' in the context of a Fifth Framework call.

assistant: **Objectives**

Description:The Berlin Neutron Scattering Center (BENSC) is a major European neutron scattering facility with several outstanding features, including cold neutrons and advanced sample environment for investigations under extreme sample conditions: high static magnetic fields up to 17T, high, low and ultra low temperatures, and high pressure. The advanced BENSC neutron scattering facilities provide high-class condensed matter research in many fields, e.g. solid state physics, magnetism, crystallography and structural chemistry, soft and complex matter research, structure and dynamics of proteins and membranes, and fundamental and applied material science and engineering For researchers from throughout the Member States of the Community and the Associated States, BENSC offers scientific and technical assistance and free access to 14 instruments: Two- and Three-Axis Diffractometer, SANS, Spin-Echo- and Time-of-Flight Spectrometer, Reflectometer, and Neutron- and X-ray scattering Residual Stress Analysis.Application:Applications for access to the BENSC facilities should be made electronically by using the On-line Proposal Submission (OPS) system at <http://www.hmi.de/pubbin/badge_prop_upload.pl>.The selection of proposals by the Scientific Panel on the basis of scientific merits is foreseen semi-annually. Deadlines for submission are 15 March and 15 September.Project Manager:Rainer Michaelsen, Berlin Neutron Scattering Center (BENSC), Glienicker Strasse 100, Berlin 14109, GermanyTel: +49-3080-623043Fax: +49-3080-622523E-Mail: rainer.michaelsen@hmi.de