RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Teaching Emerging Methods in Palaeoproteomics for the European Research Area' under Horizon 2020.

assistant: **Concept**

TEMPERA will provide international, intersectoral and interdisciplinary state-of-the-art doctoral training to prepare the next generation of specialists in mass spectrometry-based ancient protein residues analysis for biomolecular diagnostics and conservation of cultural heritage material.Due to their chemical and mechanical properties, proteins have always represented the category of biomolecules most extensively exploited by humans to satisfy basic needs, including: nutrition, clothing, sheltering and transportation. However presently there are very few specialists that have been trained to analyse ancient proteins, in stark contrast to the study of ancient DNA. The growing demand of information provided by mass spectrometry-based ancient protein sequencing will require highly specialised profiles with a multidisciplinary background in analytical chemistry, engineering, molecular biology, archaeology and art restoration.Within the TEMPERA network, a team of talented young scientists from both experimental sciences and cultural heritage conservation disciplines will be created and prepared to become a group of highly qualified specialists.The TEMPERA network aims at:(i) forming, through research-based training, the professional profiles behind tomorrow’s state-of-the-art analysis of ancient proteins from cultural heritage materials,(ii) consolidating existing constructive interaction across disciplines to focus different expertise and backgrounds into the common aim of safeguarding and enhancing European cultural heritage,(iii) stimulating, through the right set of specific research-related and transferable skills, the development of application-oriented mind set for direct or indirect exploitation of TEMPERA R&D activities.As a key TEMPERA feature, the unique contribu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Scalable target identification for metabolic liver disease' in the context of a Horizon Europe call.

assistant: **Objectives**

Metabolic dysfunction-associated steatohepatitis (MASH) is a prevalent liver disease that affects up to 6% of the general population and 15-40% of obese persons. MASH is characterized by intracellular triglyceride accumulation (steatosis), chronic inflammation and hepatocyte injury. Importantly, MASH is prone to progress into liver fibrosis, cirrhosis and hepatocellular carcinoma and, even if diagnosed early, the disease is associated with reductions in life expectancy of 2-4.5 years. Despite tremendous efforts, there are currently no approved pharmacological treatments for MASH. MASH is closely linked to obesity, sarcopenia, dyslipidemia and insulin resistance and it has become clear that adipose tissue, pancreas and skeletal muscle produce important signals that orchestrate hepatic metabolism, inflammation and fibrosis. However, the underlying mechanisms in humans remain poorly understood.In the 3DMASH project, we will utilize organotypic cultures isolated from patients with a clinical diagnosis of MASH and matched controls to comprehensively map tissue interactions and to identify novel targets for pharmacological interventions. By combining co-culture of metabolically relevant tissues from healthy and diseased individuals in microphysiological systems (MPS) with network biology approaches, we will identify novel extrahepatic signaling that positively or negatively influence MASH disease phenotypes.Moreover, we will use the established platform to screen chemogenomic libraries of G protein coupled receptors, ion channels and nuclear receptors to identify new pharmacologically accessible targets that activate “healthy” signals or inhibit “disease” cues. This project thus provides a conceptually novel perspective that considers MASH as a complex pathology caused by dys
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Demographic and Selective effects on the Quantitative Genetics of Ninespine Sticklebacks'.

assistant: **Innovation**

The aim of this project is to use the ninespine stickleback as a model to understand the relative importance of natural selection and random demographic events in shaping the evolution of ecologically relevant complex traits; harness the demographic history of the stickleback to detect complex genetic interactions affecting complex traits; improve the empirical understanding of the genetics of complex traits, and explore the effect of copy number variation (CNV) on complex traits. I will employ the latest genomic technologies to produce a panel of Single Nucleotide Polymorphisms (SNPs) to map Quantitative Trait Loci (QTL). I will test the effects of selection and demographic history with Qst-Fst analysis, to determine which genomic regions are subject to selection across populations and which ones have population specific effects. Identifying population specific QTL will allow improving our empirical understanding of how QTL interact with their genetic background, providing novel insight to understand context-dependent genetic effects. I will use the data generated for QTL mapping to detect the presence of CNV, and I will test the relative importance of this kind of genetic variability in the establishment of quantitative traits variability. These results are expected to significantly impact on our current understanding of the distribution of adaptive variation in the wild, and lead to significant advancements in the theoretical framework of adaptive quantitative genetics. In addition, these results will have a direct impact in informing selective and breeding practices of domesticated animals and plants, to balance the need of preserving genetic variability while allowing for an efficient genetic and phenotypic response to artificial selection. It will also provide us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'High-throughput characterization of host promiscuity for precisely designed synthetic viral capsid' (Hi-SynVir) targeting Horizon 2020.

assistant: **Abstract**

Traditional geographic ranges of insect pests are altered by globalization and climate change, resulting in emerging threats for natural ecosystems, agriculture and human health. It is urgent to improve our ability to swiftly develop targeted solutions to contain such threats, while minimizing unintended side effects on the environment.Densovirinae are very small, single-stranded DNA viruses pathogenic to a variety of arthropods, including pythophagous caterpillars and grasshoppers, as well as disease vectors such as aphids and mosquitoes. Host ranges appear to vary considerably amongst even closely related densoviruses. A better understanding of the molecular mechanisms underlying virulence and specificity is necessary to evaluate the risk and opportunities associated with potential use in controlling natural insect populations.We propose to discover these molecular determinants through the use of precisely designed libraries of viral genomes. We will leverage cost-effective and scalable DNA synthesis and sequencing technologies to generate high-throughput implementation and testing of precise molecular hypotheses. These will be informed by currently available knowledge and further deepened by bioinformatic analysis of natural sequences. We will produce ~106 controlled variants of the viral capsid as well as select viral regulatory sequence elements (enhancers, splicing and translation start sites). Resulting libraries will be subjected to multiplexed, deep-sequencing-based functional assays.The scale of this approach will permit to reconstitute the sequence-structure-activity relationships required to relate viral genomes to host specificity and propagation efficiency. These data will support the development of models to predict the behavior of a viral genome in a new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Degradative potential of rivers as a key driver of the environmental fate and sink of organic pollutants', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The great “riverine input-output paradox” is that even though the inputs of organic pollutants in rivers are enormous by point and non-point sources, the levels of pollutants in rivers are moderate and the final amount and impact of organic pollutants that reach the sea is small in comparison to other processes transporting pollutants to the marine environment Therefore, there is a need to study the degradative potential of rivers  (and other sinks such as volatilization) in order to understand and predict the role that rivers play in the biogeochemical cycling of organic pollutants at regional scale. The main aim of the research proposed here is to contribute in the rise of knowledge about the degradative potential of rivers as driver of environmental fate and transport of organic pollutants during longitudinal transport. Specifically, it will contribute to shed the light on the issue of transformation products and abiotic and biotic degradation in rivers using selected representative organic pollutants covering a wide window of physical chemical properties in microcosm experiments in the laboratory and in the field . The impact of transformation products has been more or less ignored in terms of modelling. Work is required to develop the appropriate modelling strategies to assess potential risks and role of these substances. This research will contribute to the knowledge of the impact of organic pollutants in riverine systems and provide modelling tools to predict the ultimate fate and transport of these pollutants to other media (seas and atmosphere).""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Scalable Full-cycle Marine Litter Remediation in the Mediterranean: Robotic and Participatory Solutions' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

SeaClear2.0 will develop a holistic approach to address the full cycle of marine litter, towards the Mission to restore, protect and preserve the health of our oceans, seas and waters by 2030. To this end, we aim to prevent and reduce marine litter pollution, particularly plastics and microplastics, in the Mediterranean via (i) Community activation, citizen empowerment, and participatory practices for identifying site-specific measures for marine litter prevention and reduction, supporting the implementation of the WFD and MSFD; (ii) Scaling up and demonstrating the SeaClear2.0 system, an innovative solution with teams of autonomous, intelligent robots for effective monitoring and collection of marine seafloor and surface litter; (iii) Providing solutions for valorization of the collected litter via better sorting and recycling; (iv) Adding novel dimensions in policy making by providing evidence for new legislation and the implementation of existing rules to achieve Good Environmental Status and (v) Accelerating the uptake of our solution by demonstrating its scalability and replicability to the Mediterranean basin and beyond in three full-scale demonstrations, three pilot tests, and at least five associated-region projects.SeaClear2.0 impact ranges from the reduction of upstream and beach litter via public awareness and citizen activation; through effective litter monitoring using both robotic mapping and public reporting in a gamified app; to direct collection of at least 57% of existing litter in the areas covered by the robot teams, with options for valorization. The singular selling point of SeaClear2.0 is our unique blend of technological innovation (ii, iii), community-activation (i), and policy-making (iv).We achieve all this by exploiting consortium expertise i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Paradoxes and Metaphors of Time in Early Universe(s)' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

PROTEUS studies main strategies devised by Western philosophy in representing time in cosmology. It aims at modifying current metaphysics and its relationship with cosmology in the light of recent scientific debates in quantum gravity and quantum cosmology, thereby boosting a new research field in history and philosophy of cosmology. The project is based on two hypotheses: 1) the history of philosophy reveals a guideline that can be traced back to Plato and that characterizes physical and metaphysical approaches to the question of the beginning of the universe in terms of a tension between fundamentality and non-fundamentality of time; 2) there is a conceptual problematic assumption in Western culture and it consists in shaping the problem of the origin of the world as a problem of thinking about the very same conditions of possibility of the origin of a process that is not in time. The project spells out the conceptual roots of current representations of time in quantum gravity and quantum cosmology and highlights the conceptual break that they provide with respect to philosophical concepts of time portrayed in previous systems. PROTEUS explores in detail the notions of time and the paradoxes emerging in the philosophy and cosmology of Plato and Kant and identifies the fundamental characters of emergent time in current quantum gravity theories. In identifying these fundamental features, PROTEUS produces conceptual innovation in metaphysics in such a way that philosophical investigation is complementary to the development of current theories. PROTEUS elaborates alternative argument(s) to anthropic principle, as well as new categories accounting for the notion of ‘contingent necessity’ of the world. The research team includes members from different backgrounds (philosoph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'VOlcanic climate forcing over the onset of the Little ice age through TEphra geochemistry and Stratospheric Sulfate isotope analyses in polar ice cOres' (VOLTESSO), addressing dissemination and exploitation.

assistant: **Impact**

The most recent climatic shift in the Northern Hemisphere before anthropogenic forcing became dominant was the transition from the Medieval Warm Period (MWP) to the Little Ice Age (LIA), a cooling that lasted until the late 19th century. A leading hypothesis for the LIA onset is that a series of large volcanic eruptions during the MWP-LIA transition, amplified by sea ice/ocean-related feedbacks, drove sustained cooling. Seven presumed tropical and six northern high-latitude eruptions have been identified from ice cores; however, their precise sources and the amounts of stratospheric sulfate aerosol injection remain poorly constrained, hampering robust assessments of their climatic forcing. This project addresses these gaps by applying state-of-the-art tephra geochemistry and sulfur isotope analyses to polar ice cores to determine eruption sources and quantify stratospheric sulfate aerosol loadings for major eruptions between 1150 and 1350 CE. The new volcanic forcing record will be combined with existing paleoclimate data products to determine the climate impacts of closely timed eruptions at the start of the LIA. The project will also use aerosol-chemistry-climate models to simulate the impacts of Northern Hemisphere and tropical eruption sequences, assessing which scenarios – if any – could plausibly trigger the LIA through sea ice/ocean-related feedbacks. This comprehensive approach – combining novel ice-core measurements, comparative paleoclimate records, and model evaluation– will substantially advance understanding of whether, and by what processes and feedbacks, a sequence of major tropical and northern high-latitude volcanic eruptions contributed to Northern Hemisphere cooling or acted as a trigger for the onset of the LIA. Ultimately, the findings will provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Charting the ROles of crowns in Ancient Greece', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

CoROnA (Charting the ROles of crowns in Ancient Greece) conducts a comprehensive study of ancient Greek crowns (stephanoi) from the 8th to the 1st century BCE, chiefly in Athens. By integrating thorough philological, epigraphical, and visual analyses of both textual and material evidence with contemporary theoretical frameworks such as New Materialism and New Institutionalism, CoROnA offers the first methodologically informed exploration of crowns as a pervasive symbol in Greek society, providing new insights into the diverse uses of crowns in both ‘Soft Institutions’—e.g., religious practices, symposia, and athletic competitions—and ‘Hard Institutions,’ i.e., honorific crowns. The project’s objectives are threefold: i) to map the uses of crowns by compiling a database of literary and epigraphical references, as well as a dossier of notable artefacts and images on vases/sculptures, and to record their specific functions and contexts; ii) to analyse the intersections between Soft- and Hard-Institutional uses, particularly how crowns used in Soft Institutions influenced their use as public honours, serving as tokens of the reciprocal relationship between the individual and the community; iii) to address the inherently intersectional meanings of crowns in Classical Greece, as these served to symbolise not only the civic worth of male citizens (an honour conferred not only for specific and outstanding political and financial benefactions but also to reward magistrates for undertaking their ordinary duties, e.g., as councillors) but also the worth of women and enslaved persons. Through this analysis, CoROnA reconsiders the crown’s role in expressing Greek honour and ethos, offering new perspectives on the connections between honour and democratic ideology. It also vindicates
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sensing Anywhere IIoT Ultra-Energy Efficient' (KUNAK), addressing dissemination and exploitation.

assistant: **Impact**

There are processes or situations in isolated environments, where there is no electricity or communications and autonomous energy systems are required that use batteries that last longer than 10 years. These processes are very difficult to monitor. These processes are also quite expensive to control in industrial environments that require very low power consumption.We have developed the comprehensive Kunak solution, a system to deploy IIoT solutions, whose ultra-energy efficiency characteristics provide great advantages in isolated and/or complex environments (Wireless Devices that operate in sleep mode most of the time), which makes it unique.Kunak is an end to end solution, that encompasses components from the hardware itself, embedded and encrypted software, to wireless communications and the platform on their own cloud (KunakCloud), receiving data communications management, sensors and equipment, with data display layer and API for web services. Clients can access information through it, export it, integrate it into existing systems, change remote settings, operate the equipment, apply big data and mass storage techniques, ensuring the interoperability of sensors, calibration, protocols and the model data with any existing system.The Kunak system facilitates the rapid deployment of IIoT solutions and allows clients to focus exclusively on the final application, and the exploitation and analysis of data.Kunak is a disruptive solution because we have developed a complete system, designed with the goal of achieving ultraefficient energy in the design of each of its components and in the interaction of each of these with the other components.Kunak has been sucessfully implemented with several clients. The objective of this phase 1 is to complete a feasibility study to f