RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Two-dimensional interlocking molecular assemblies. precursors of catenane-containing membranes', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The aim of the project is the design and preparation of discrete tetrameric pseudorotaxanes and rotaxanes with novel topology. These will be subsequently used for a controlled oligomerization so as to obtain oligomeric mutually interlocking species . The procedure, reminiscent of knitting" , represents first steps towards larger 2- D interlocking assemblies, such as membranes. The proposed experimental approach is based on the self-assembly of complementary building blocks driven by coordination bonds. The self-complementary building unit consists of a macrocycle and a connected string, both containing a bidentate 1, 10-phenantroline ligand. The threading process is induced by an addition of a coordinating metal (Cu+). The essential condition for the required topology is the planar arrangement of the chelating ring and the string. As a consequence, the formation of the discrete 2-D tetrameric pseudorotaxane, in which the individual units are perpendicular to one another, may be anticipated. The terminal groups of the string then will be modified by the attachment of bulky stoppers to prepare a free tetrameric rotaxane, or by addition of polymerizable groups to prepare 2-D interlocking oligomeric assemblies."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Self- Management of Cognitive Future Internet Elements', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Self-NET aims to introduce, design and validate an innovative paradigm for cognitive self-managed elements of the Future Internet. The present Internet model is based on clear separation of concerns between protocol layers, with intelligence moved to the edges, and with the existent protocol pool targeting user and control plane operations with less emphasis on management tasks.Self-NET shall engineer the Future Internet based on cognitive behaviour with a high degree of autonomy, by proposing the operation of self-managed Future Internet elements around a novel feedback-control cycle. The Self-NET proposed Distributed Cognitive Cycle of System Management shall facilitate promotion of distributed management over a hierarchical distribution of management and (re)configuration cognitive cycles, breaking down the execution and decision making levels to (autonomic) network elements, network domain types and up to the service provider realm. Moreover, Self-NET shall study integrated solutions for knowledge management within autonomic elements, including knowledge distribution among the various autonomic elements, as well as a coordination scheme for the cooperation among different network domains. Self-NET shall propose a framework for the transition of traditional monolithic approaches for management actions and protocol stack design to more flexible and dynamic schemes, by introducing autonomic models for localised management decisions. Furthermore, Self-NET shall provide a peer-to-peer style distribution of responsibilities among self-governed elements of the Future Internet, therefore overcoming the barrier of current client-server in the operation of mobility management, broadcast/multicast, and quality of service mechanisms.The consortium shall develop a prototyping en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Rationally Designed Supramolecular Bio-inorganic Hydrogels for Tumour Therapy' (2007-2013).

assistant: **Innovation**

Almost 2 million people in Europe are diagnosed with cancer each year, over half of whom die within 5 years as a consequence. Cancer has been designed by the ESF as one of the priority targets for the development of new technologies. The side effects and poor efficacy of today’s treatments mean there is a pressing need for new innovative multifunctional drug carriers able to specifically target tumours and decrease patient morbidity.  HOT SHOT is a multidisciplinary project which proposes such a novel drug delivery approach based on highly engineered nano-materials. The drug carriers will consist of composite hydrogels made of protein-resistant polymer molecules cross linked together by rationally designed self-assembled peptide strands which can disassemble in response to stimuli such as defined temperature and pH transitions. Gold nanorods or nanoshells will be covalently bound to the termini of the peptide strands and embedded within the hydrogels. Thanks to the innovative design and attractive chemical and physical properties of the components, the drug carriers will possess notable properties: a) drug delivery specifically to tumours by means of enhanced permeability of tumoral vascular system to nano-sized hydrogel beads; b) drug release on demand or in response to exact local conditions (i.e. lower pH of the tumoral tissue with respect to blood); c) gold nanoshells and nanorods acting as contrast agents in tumour tomography imaging and d) as heat sources for tumour thermal ablation therapy when irradiated with near-infrared light. HOT SHOT will contribute to the creation of a multidisciplinary network of research groups within Europe in which the fellow will be embedded and experience excellent collaborations. It will provide the fellow with intense multidiscipli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Learning to Design Sweet Renewable Hydrogels - Development of Experimental Protocols and Deep Learning Models to Decode Complex Structure-Function Relatioships' in the context of a Horizon Europe call.

assistant: **Objectives**

Gels are 3D entangled polymer or particle networks that present, simultaneously, solid and liquid-like properties. Gels are widely present in daily life products such as contact lenses, food thickeners, platforms for drug delivery, or wound healing ointments, among others. Carbohydrate-based hydrogels have gathered increasing attention for a wide range of biomedical and industrial applications (e.g. tissue engineering or water decontamination) due to their biocompatible, biodegradable and non-immunogenic features. However, the development of most gel-like materials is currently limited due their high production costs and greatly pollutant manufacturing techniques. In addition, the great structural complexity of gels, where different lengths scales and isotropic and anisotropic phases coexist, limit their characterisation at the molecular and macroscopic scales, thus hindering the design and development of functional gels with tailored properties. High Resolution Magic Angle Spinning (HR-MAS) and solid-state NMR (SSNMR) spectroscopy constitute the most powerful technologies to characterise the structure and dynamics of hydrogels at the molecular level, not accessible by other techniques. The specific objectives of the Sweet2Gel project are (i) to develop novel HR-MAS and SSNMR protocols for the characterisation of carbohydrate-based gels, (ii) to develop predictive deep-learning-based models that allow to decipher hidden relationships between the molecular and macroscopic properties of the gels and (iii) to improve the molecular models of carbohydrate gel particles by a combination of molecular dynamics and deep learning approaches. Hence, the Sweet2Gel Project aims to accelerate the development of a new generation of renewable materials with rationally designed properti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unraveling molecular quantum dynamics with accelerated ab initio algorithms' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Many physical and chemical processes in nature as well as an increasing number of man-made devices exploit the quantum properties of electrons, nuclei, and the quantum signatures of the coupling between nuclear and electronic motions. To optimize the design of novel devices and to correctly interpret physical processes studied, e.g., by experiments probing the molecular dynamics induced by interactions with ultrafast laser pulses, quantitative simulations are required. Although ninety years have passed since the discovery of Schrödinger’s equation, these simulations remain extremely difficult for systems with more than a few degrees of freedom.  While some physicists are satisfied with a theoretical model that describes the system qualitatively, in chemistry the promising term ``ab initio quantum molecular dynamics'' is frequently misused for methods treating nuclear motion classically and using quantum mechanics only for electrons. The first goal of this project is, therefore, to bridge these two philosophies and combine accurate ab initio electronic structure calculations with accurate quantum or semiclassical treatment of the nuclear dynamics.  Since the exact solution of time-dependent Schrödinger’s equation scales exponentially with the number of atoms, accelerating computers even by orders of magnitude will not break the exponential barrier to simulating molecular quantum dynamics. The second goal of this project is, therefore, developing and implementing both exact and approximate computationally efficient quantum dynamics methods applicable to polyatomic molecules. The last goal of the project is developing systematic methods for interpreting spectra of complex systems in terms of the underlying nuclear and electronic dynamics. To summarize in simple terms, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Connecting mitochondrial defects to reduced autophagy in metabolic liver diseases through FATP2.'.

assistant: **Innovation**

Hepatic mitochondrial dysfunction is a common clinical feature of several metabolic disorders, including type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH). Mitofusin 2 (MFN2), a transmembrane protein necessary for mitochondria-endoplasmic reticulum tethering, is decreased in T2D and NASH. Moreover, its liver-specific ablation promotes the manifestation of NASH and increases the susceptibility to developing liver cancer in mice. Recently, the Zorzano lab has identified several interactors of MFN2 involved in lipid transport. The ""MITOTUA"" project focuses on the study of FATP2, a fatty acid transporter/acyl-CoA synthetase predicted to participate in mitochondria-associated autophagosome formation during starvation. We plan to perform a battery of in vitro and in vivo experiments to properly characterize the mechanistic implications of MFN2-FATP2 interaction to autophagy activation and mitochondrial function. The ""MITOTUA"" project will also investigate the relevance of FATP2 to the hepatic alterations connected to the metabolic syndrome by using murine models of liver steatosis (ob/ob and db/db mice) and NASH (CDAHFD diet) and analyzing liver biopsies of patients with fatty liver disease. The combination of my strong background in complex metabolic syndromes and the well-recognized expertise of the Zorzano lab in the study of autophagy and mitochondrial metabolism will undoubtedly result in a well-conducted scientific project and a successful reciprocal transfer of knowledge. Overall, this fellowship represents a unique opportunity to enroll in a prolific research group of a distinguished institution, taking advantage of an ecosystem shaped to maximize the potential of this proposal and acquire new competencies that complement my scientific preparation, re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Entrainment and Production In Children with dyslexia' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Dyslexia is often thought of as a deficit that causes someone to transpose letters within a word or to see letters backwards. However, decades of research have shown that people with dyslexia do not have issues with seeing letters, but rather with how they process the sounds associated with these letters. The purpose of the current project is to broaden our understanding of the underlying deficits in dyslexia and to identify clinical markers that can help with early identification. Most studies have focused on how individuals with dyslexia perceive speech sounds (using behavioral or neurophysiological paradigms). However, little is known about speech production ability in this population. Therefore, there is a critical need to examine production in this population which can later be used as an early diagnostic marker by speech language pathologists.The current project combines both speech production and neurophysiological paradigms to better understand the underlying sources of dyslexia, and to identify new markers associated with reading disorders which we can be implement clinically. In the first experiment, I examine the relationship between phonological processing skills and speech production in typically developing children. This will inform how we can use speech production patterns to identify children at risk of developing dyslexia. In the second experiment, I examine whether neurophysiological brain data is associated with speech production markers in children with dyslexia. This project has important clinical implications on diagnosis and earlier identification of dyslexia.


**Keywords:** Reading, Speech production, Speech perception, Auditory entrainment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Characterization and optimisation of bioactive glass coatings onto titanium alloys surfaces for dental implants' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The development or modification of man-made materials to interface with living host tissue i.e. implants made of biomaterials is of great interest in the realm of medical implants. Pure titanium or titanium alloys such as Ti-6Al-4V are bioinert, which mean s that, apart from being non-toxic, once implanted in the host organism they become encapsulated by a fibrous tissue. One of the approaches to enhance the bioactivity of the surface of the titanium in order to improve the mechanical fixation and reduce the healing time is to coat the surface of the implant with a bioactive glass.The central goal is the microstructural and mechanical characterization of an engineered bioactive glass coating onto titanium implant surfaces, which shows a graded structure in terms of titanium/ glass composition, in terms of glass properties (thermal expansion coefficient and bioactivity) and with respect to porosity at the external surface of the implant. This bioactive glass coating will be produced by novel techniques of elect rophoretic deposition. The project will contribute to a better integration of the metal substrate and bioactive ceramic coating for implant applications.At present, the interface is the weakest link in the implant, especially because of the difference in chemical bonding and thermal expansion mismatch between metals and ceramics. The concept of a functionally graded interface opens up the possibility to gradually tailor the microstructure of the interface.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Role of obesity in the development of hepatocellular carcinoma' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Obesity is associated with increased risk for epithelial tumors such as hepatocellular carcinoma (HCC). It is not known, however, whether obesity increases the risk for HCC simply because it promotes cirrhosis, a general risk factor for HCC, or through other mechanisms that operate independently of cirrhosis. Among these, obesity is associated with a chronic inflammatory state, with the release of cytokines such as IL-6 and TNFalpha, well-known HCC mediators. Obesity is normally linked to diabetes and in consequence, to hyperinsulinemia. This increase in circulating insulin levels is suggested to be a factor that contributes to cancer. Moreover, the increase in free fatty acids (FFA) in blood among obese patients promotes a compensatory response from liver that activates the transcription of genes required for beta-oxidation, leading to a reduction in non-physiological stores of lipids in the liver. This increase in beta-oxidation could result in oxidative stress, inflammation and the production of lipid peroxidation bioproducts, which are known mutagens. The precise mechanisms whereby FFA and cytosolic triglycerides exert their effects, resulting in the diabetic phenotype, remain poorly understood. Emerging evidence nonetheless links microRNA (miRNA) with lipid metabolism, suggesting that these small RNAs mediate this increase in beta-oxidation.Our goal is to study how the components of the obesity state (inflammation, steatosis hyperinsulinemia and microRNA control of gene regulation) affect HCC development. We will use several mouse models in which one or more of these factors are reduced following induction of metabolic disease. We will also determine whether specific miRNAs that are down- or upregulated in the liver of mice on a high fat diet are implicated in HCC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Caveolin-1 integrates stromal mechanical forces  chemo-resitance to foster tumor progression' (CAVCER) targeting Seventh Framework.

assistant: **Abstract**

Breast cancer affects 1 in 8 women and is the chief cause of female cancerdeaths in the EU. Early detection continues to improve survival, but prognosisworsens significantly after metastasis. Metastasis and chemoresistance are linkedphenomena, but the molecular basis is unknown. The evidence suggests a role forCaveolin1 (Cav1): i) Cav1 mediates biomechanical remodelling of the extracellularmatrix by cancer-associated fibroblasts (CAFs), promoting invasion (host labpublications); ii) Cav1 is involved in drug/radiation resistance, and the Cav1β isoformmight regulate resistance of breast tumour cells (TCs) to paclitaxel (literature); iii)The Cav1 content of breast-TC exosomes correlates with metastatic potential (ourpreliminary data).We propose that acquisition of invasiveness by TCs is related to their releaseof Cav1-containing exosomes. Cav1-activated CAFs then increase matrix stiffness,providing the appropriate milieu for TC metastasis. The N-terminally curtailed Cav1βprecludes chemotherapy-induced tyr14 phosphorylation, preventing Bcl2 binding andconferring resistance. Cav1 α and β might thus balance the interplay between TCsand CAFs during tumour progression.To integrate these data and verify our hypothesis, we propose state-of-the-art approaches andmultidisciplinary strategies, ranging from cell biology to animalmodels and clinical screening studies. As side products, tools of interest will beproduced such as a new antibody to Cav1β, useful for stratifying patients accordingto their likely benefit from paclitaxel therapy, and a new Cav-/- mouse generated byZFN targeting in the NSG strain, which promises a method for conducting humantransplants in genetically modified animal models.The complementary expertise of fellow and host lab, coupled with theexcellent scientifi