RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Identification of novel iron metabolism genes by genetic screening in Drosophila' under Seventh Framework.

assistant: **Concept**

The Drosophila model will be used for two complementary and unbiased genetic screens, designed to identify novel genes that affect iron homeostasis in multi-cellular organisms. S. cerevisiae has been used successfully for the same purpose, however this unicellular organism does not express neither ferritin (the major iron storage protein) nor iron regulatory proteins (the major regulators of intracellular iron homeostasis in mammals). Knockout mouse models of known iron metabolism genes have been developed to study relevant human disorders, but have limited value for identification of novel genes. To study ferritin expression in Drosophila, we have previously characterized a fly strain expressing GFP-Fer1HCH, which is incorporated into endogenous ferritin complexes that sequester iron and show subcellular and tissue specific expression patterns that are identical to wild type ferritins. Green fluorescence is readily observed in the intestine, brain and in large characteristic pericardial cells of first instar larvae. If fed on iron, ferritin expression is induced in the anterior portion of the intestine. For the first screen EMS-mutagenized chromosomes will be crossed in trans with the GFP-ferritin carrying flies, looking for altered expression patterns. The second screen is based on the observation that ubiquitous overexpression of ferritin can be lethal under iron limiting conditions. Ferritin-induced lethality is rescued by iron supplementation, suggesting that the cause of lethality is related to iron sequestration by excess ferritin. We expect that, under low iron conditions, flies overexpressing ferritin will only grow if we genetically reduce the expression of factors important in ferritin assembly or iron incorporation into ferritin. Combining the two screening
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Revolving around the ubiquitin‒proteasome system: USP2-targeted degrader'.

assistant: **Innovation**

Targeting DUB enzymes has recently emerged as a promising opportunity for drug discovery that might lead to more selective, less toxic drug profiles. Target validation of these enzymes is currently a priority in the field, as we are lacking of appropriate chemical probes for most of them. A clear example is USP2, whose chemical inhibition has been barely explored, leading to a poor-quality chemical probe that has been extensively used by biologist during the last decade. Hence, this multidisciplinary project emerges to address the identified unmet need of providing the scientific community with an appropriate chemical probe for a confident interrogation and further understanding of USP2 biology and disease. This probe will be useful for a suitable validation of this promising target and can eventually feed drug discovery projects for USP2-related cancer treatments.Herein, we aim to develop a, USP2-Targeted Degrader (USP2-TD) that overcomes the lack of selectivity and potency of its parent counterpart. This small-molecule USP2-TD will enable investigations of selective USP2 downregulation with exquisite quantitative and temporal control of protein levels. To this end, the proposed research deal with the identification of solvent-exposed region at the parent, the discovery of the USP2-TD, and its validation as chemical probe for USP2.


**Keywords:** Deubiquitinases,  ubiquitin-specific protease 2,  challenging protein targets,  biophysics,  chemical biology,  chemical probe,  targeted protein degradation,  PROTACs,  drug discovery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Large Area Molecularly Assembled Nanopatterns for Devices'.

assistant: **Concept**

Scaling has driven the microelectronics industry for over 40 years and revolutionised information and communication technologies, health care, education, engineering, etc. Maintaining progress has becomes more challenging and costs of fabrication facilities are rising exponentially. Possible technical/cost solutions centre on development of ‘bottom-up’ techniques to (nano)pattern (the patterns yield device elements) surfaces rather than ‘top-down’ photolithographic (PL) methods that are the major cost of manufacturing circuitry (a single PL system is ~€65 million for next generation devices). Self-assembly is one route to nanopatterns but regularity/alignment over large areas is not consistent with circuit manufacture. Recent work on the self-assembly of block-copolymer (BCP) systems suggests that realisation of patterns of small feature size (~10 nm), at high density (i.e. spaced at ~10 nm), in precisely defined positions (to an accuracy of < 10 nm) on a large area substrate (12”) is possible. This proposal will develop BCP methodology into a set of process techniques for subsequent industrial pre-development. The methodology centres around a combination of bottom-up and top-down techniques to provide the fidelity required to make the methods reproducible and reliable. This proposal would have significant value:- - Enable continued development of devices towards their ultimate performance. - Allow development of advanced circuitry at lower costs. - Prevent monopolisation of the semiconductor industry by 1 or 2 companies that can afford capital costs by opening the market to new competition. - Afford the EU with opportunities to develop profitable companies in materials, process equipment and emerging device technologies. Without a suitable EU-level engagement in this a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A multimedia repository on European food science: production, quality and safety' in the context of a Sixth Framework call.

assistant: **Objectives**

Better and safer food production hold promise to improve the quality of life in our society. However, because of the complexity of the issues and the considerable background knowledge required, the balance between benefits and risks are not easily explained or evident. The lack of support for agricultural and food applications of biotechnology in Europe, according to the EC, is seriously slowing down biotech R&D in the EU, particularly in the private sector, and may put at risk Europe's competitiveness in a promising sector of new technologies. Broad public support is essential to attract human, financial and industrial resources to develop the technologies to meet societal needs and increase European competitiveness. Constructive dialogue with the key stakeholders is needed to minimise unfounded concerns and maximise public empowerment on these complex issues, while at the same time, allowing a positive feedback to assure that science is moving forward in cohort with social needs and expectations. The Multimedia Repository on European Food Science (MREFS) aims to narrow the gap between science and scientists on the one hand and key stakeholders: the general public, educators and media on the other. It will address European biotechnology research in the area of Food Quality and Safety. The chosen stakeholders will be reached by using effective communication platforms: television, video, multimedia, internet and a publisher. The main deliverables of the project are sixteen high quality short films from sixteen different EC sponsored projects. There will be three levels of disseminating the film contents and raw footage: i) through broadcasting media; ii) using an on-line internet based multimedia library and iii) by direct distribution of VHS, CD-ROM and DVD to target gr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'FINN-IMT' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

This project will be carried out by Technology Development Centre of Finland (TEKES) to act as a promoter for Innovation Management Techniques. The project covers the whole area of Finland. The intention in this project is to utilise and disseminate existing, national or European, IMTs that have proved to perform well.At first stage the following IMTs have been selected:- Business strategy and technology analysis- Strategy module (for hi-tech companies)- Deep technology analysis- Systematic product development.The main objectives of this project can be divided into the following six tasks: a) Identifying and promoting good methodological approaches on selected IMTs for the benefit of SMEs.b) Disseminating the good practices of IMTs to consultancy companies and SMEs.c) Identifying good foreign IMTs and transferring of them into Finland.d) Encouraging SMEs to use newest technology in a strategic way.e) Encouraging SMEs to use external help. f) Testing of the applicability of selected IMTs for Finnish SMEs in 40 real cases.The project pays a special attention to small or starting high-tech companies.The foreseen number of consultancy assignments in SMEs for this project is 40. The assignments will consist of maximum 10 man-days of external consultancy using two 5 day modules. TEKES will arrange the selection and training of experts needed for this project. It will also build up the necessary quality control mechanisms.The good practices of Finland and other European countries will be disseminated through seminars to reach a large number of SMEs, consultants and development organisations. The suitability of any new practices will be tested before their dissemination. The experience gained from Finland can be transferred to other countries through the appropriate Accompanyin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Catalytic Synthesis of Sulfonamides' under Seventh Framework.

assistant: **Concept**

Sulfonamides are functional groups that feature in a significant number of pharmaceuticals, with applications in a variety of indications.  Conventional syntheses of sulfonamides usually involve two or three synthetic operations, and often feature low-yielding steps.  The chemistry involved also limits the substrates that can be converted to sulfonamides.  This proposal seeks to develop an alternative synthesis of sulfonamides; the proposed synthesis will be achieved in a single operation, employ readily available reagents and substrates, and be conducted under mild conditions.  The key to the proposed synthesis is to employ a three-component synthesis involving the catalytic combination of an aryl halide, an amine and sulfur dioxide.  Achieving the synthesis in a single operation will have significant advantages in terms of waste production, energy required, as well as the time needed to prepare the desired sulfonamides. These are important considerations for both small scale discovery synthesis, as well as the large scale synthesis of these materials. The developed methodology should also be applicable to the preparation of related sulfonate esters and sulfones.  The latter stages of the project will explore the application of the developed method to the synthesis or selected target structures that are difficult to access using conventional methods, and to the synthesis of heterocycles.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mechanisms of formation of ionising radiation-induced chromosomal aberrations: Impact of repair pathways and nuclear architecture' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Chromosomal aberrations are efficiently induced by ionising radiation and contribute to a great extent to the development of cancer. Increased resolution of molecular cytogenetics along with the availability of cell lines and knockout mouse models sensitive to radiation, provide the basis for further unravelling of the mechanisms of formation of chromosomal aberrations. The proposal aims at studying the initial DNA damage, its repair and the biological factor influencing the ultimate yield of chromosomal aberrations. To reach this goal different strategies will be undertaken including exploitation of novel technologies, site-specific induction of DNA strand breaks and the use of cells with defined defects in repair. The outcome of this study will contribute to understanding of the mechanisms of chromosomal aberration formation and will ultimately help to extrapolate to the effects low doses and low dose-rates.In this project we have made main achievements with regard to the understanding of the formation of ionizing radiation induced CA particularly emphasising the role of nuclear architecture in the formation of CA. The most important findings are summarized:-The repair of DSB displays a fast and slow component. The fraction of radiation induced DSB that is very fast repaired, might represent repair of damage possible related to free radicals induced DNA lesions in open chromatin. The nature of the slow repairing DSB fraction is unclear but unlikely to be related to complex damage (clustered damage) induced by free radicals.-Immunostaining of histone H2aX-P provides a very sensitive tool to measure DSB at single cell level in a variety of tissues.-Gene density/transcriptional activity in mammalian chromosomes has no major influence on the formation of CA.-The genome wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Functional Metal Organic Frameworks as Heterogeneous Catalysts'.

assistant: **Innovation**

Metal Organic Frameworks (MOFs) are novel organic-inorganic crystalline materials, promising to become a powerful and flexible family for different industrial uses within catalysis, adsorption and sensor technology, overcoming many of the limitations of Zeolites. MOFs may display extreme porosity, and their functionalities can be tailored by using functional precursors in their preparation or by post-functionalization using standard techniques of organic- and organo-metallic chemistry. These features will be studied in the present project for the development of new heterogeneous catalysts and gas adsorbents.The project aims at:1) developing reproducible and scalable synthesis procedures for known and new MOFs, also exploiting combinatorial techniques;2) understand at the molecular level the interactions governing their stability, self-assembling and adsorption properties, by means of combined experimental and theoretical modelling efforts;3) develop functionalisation routes to create MOF-based single-site catalysts for two emerging industrial processes;4) exploit the functionalised MOFs as catalysts in two emerging industrial processes;5) exploit Pt-functionalised MOFs as catalysts for C-H activation at moderate conditions;6) exploit MOF catalysts in selective oxidation and SCR reactions; and7) exploit selected MOFs as adsorbent or storage media for non-condensable gases (hydrogen and methane).The work packages of the project comprise the synthesis, characterization, modelling, and testing of the materials, as well as a technology implementation plan for their production and use.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Setting concepts into motion. r&d policies and scientific tools in support of sustainable development decision making'.

assistant: **Concept**

The aim of the proposal is to set up a two days workshop so as to build awareness within the world of the R&D policy makers on what sustainability research is and how it can be implemented into research programmes. To set the concepts into motion, to move forward with sustainability research, there is a need for discussion with the science community on the particular novelty of approach, its key questions, appropriate methodologies and institutional needs. There is a need to include sustainability science in the research programmes and how to evaluate the sustainability of projects and programmes. The project aims to address the EU sustainable development policy context and its consequences for R&D, to discuss methodologies and criteria for evaluating research project and programmes, to analyse some research projects or scientific approaches undergone in the field of SD.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Mucosal Vaccines for Poverty Related Diseases'.

assistant: **Concept**

The project is focused on the development of mucosal vaccines against AIDS and tuberculosis (TB) and is based on the use of antigens validated as safe and effective in animal models. Mucosal vaccines present advantages of practical and social relevance when compared to parenteral. To ensure vaccine compliance, accessibility, and coverage, vaccines should be designed which can be administered by convenient mucosal routes of delivery. Mucosal vaccines, inducing both local and systematic immune responses, are considered moreeffective in controlling mucosally-acquired infections, such as HIV and TB.The project consists of two major parallel interlinked tracks: i) phase I trials of mucosal immunization using antigens and adjuvants validated in previous preclinical and clinical studies ii) development of new candidate vaccines for mucosal immunization and their comparative selection in animal models. Antigens such as GAg, V2-deleted gp 120, Tat (HIV-1), and Ag85B/ESAT-6 hybrid molecule (TB), and adjuvants such as LTK63 and HSP70, will be used in combination for phase I trials to be performed first in Europe and than in Africa Development of new vaccine candidates will not include antigen discovery but would rather be based on the novel use of adjuvants and delivery systems in combination with promising antigens. Animal models of increasing relevance for human vaccines will be used to compare new candidates and to select those which should proceed to phase I trials.The final expected result of this Project is to provide candidate mucosal vaccines, with proved safety and immunogenicity in humans, that could subsequently enter the path towards licensure through phase II and III clinical trials. The European Developing Countries Clinical Trials Partnership which is expected to be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The therapist in your pocket - AI assisted ecosystem for enabling a patient-centric approach to mental health' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The societal and economic influence of mental problems (affecting almost 200 million European citizens) is huge. Mental issues directly impact in the number of deaths, healthcare costs and, indirectly, in workforce productivity. However, over 40% of Europeans with mental issues are untreated and, furthermore, 50% of those treated are misdiagnosed. Neither traditional nor current digital approaches overcome this situation, further aggravated given the siloed ""solutions"" they provide. HYGGii autonomously provides 1st-assistance, personalised support and orientation to individuals suffering from mental problems. Its Artificial Intelligent (AI) algorithms are specifically designed to acquire knowledge from multi-language (text/audio) inputs and from smartphone-embedded and wearable sensors, to then provide assistance via text/audio answers, therapeutic-games, VR- interfaces, etc. HYGGii is integrated into v-IfMH, an ecosystem of real practitioners able to assist patients beyond HYGGii's possibilities.Being suitable to support 75% of mental issues, 24/7, and with a cost to patients 90% lower than traditional approaches, HYGGii completely aligns with the European challenge for ""addressing mental health conditions and promoting good mental health in the most effective way"". In this way, HYGGii reduces the gap between the need for mental health treatment and its provision, boosting the cooperation of already existing stakeholders (like mental-Health Service Providers –mHSP– and other providers of health services and devices).Driven by the initial success commercializing our digital therapies (VR therapy, neurofeedback, etc.) from our premises in Zürich, HYGGii's disruptive approach will (1) guarantee the scalability of our therapeutically methodology, also (2) enabling v-I