RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The role of bacteriocins in shaping oral biofilms'.

assistant: **Objectives**

In the BOB project, the role of bacteriocins in shaping oral biofilms will be investigated by moving a Spanish researcher currently working in Ireland to the Norwegian University of Life Sciences. Bacteriocins are antimicrobial peptides produced by bacteria primarily known as killer peptides, and producing bacteria protect themselves expressing dedicated immunity proteins. The rise of whole-genome sequencing has revealed the presence of a large number of incomplete bacteriocin gene clusters in bacteria, and specifically, the presence of unpaired bacteriocin immunity genes. Little is known about the social role of bacteriocins and immunity genes. By using state-of-the-art bioinformatics, advanced genetic engineering techniques, biofilm assays and microscopy, BOB will interrogate how these components involve in microbe-microbe interactions during the formation of oral biofilms. First, an in silico analysis will give an overview of bacteriocin associated genes in oral streptococci. By construction of isogenic mutants and fluorescence labelling of strains, a set of biofilms will be studied to explore the role of these genes in biofilm formation. Initially, a biofilm model will be optimized using a known bacteriocin-producer and biofilm-forming Streptococcus mutans. Further the significance of unpaired immunity bacteriocin genes both in a mono and a mixed streptococcal biofilms will be examined. To gain a deeper understanding of how bacteriocin and immunity genes are regulated in oral biofilms, transcriptional reporters and RNA-seq will be performed. During the project, I will receive high-quality training through research that will significantly improve and complement my scientific knowledge and provide a strong platform for building an independent research career. The know
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Implementation of a highly integrated system for documentation, configuration and code re-use in a heterogeneous software development environment' to be submitted under Fourth Framework.

assistant: **Abstract**

The need for high product quality and traceability in the development process is a growing demand in the very competitive telecommunication market as is the need for short time-to-market development. To meet these demands the development process must be improved in project management, quality and efficiency. Because of this the objective is to implement and evaluate 1) an on-line software documentation system performing satisfactorily in a heterogene software development environment, 2) an on-line configuration management tool to keep track of versions and releases, with key words being high integration, easy usage and low administration costs.THE EXPERIMENTThe experiment will be based on what is known as the second generation Home Communications Centre(HCC), which combines several home office functions such as handsfree telephone, answering machine, telefax, modem and much more into one stand alone unit. The HCC project will be used for quality measurements of all project objectives. Time to market, software error reduction in the development phase as well as on final releases, unambiguous version and release control and documentation will be the basic yardsticks for quality measurements.Digianswer A/S employs 20 people, approx. 10 people will be involved in the experiment.EXPECTED IMPACT AND EXPERIENCEThe expected results of the project are: improved control of project management, more effective design process, easier and more systematic training of new engineers and improved motivation for quality aspects during software development. This will make Digianswer A/S a more professional business partner and a more competitive product development company.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Versatile and Environmentally Friendly New Reaction Methodologies for Synthetic Organic Chemistry with Application to Natural Product Synthesis'.

assistant: **Innovation**

Enantioselective catalysis is the most important frontier of synthetic organic chemistry today. As nature uses enzymes to catalyze highly stereoselective reactions, it was long assumed that large and complex structures are essential to attain high enantioselectivity. However, it has now been illustrated by MacMillan and others that small molecule organic catalysts can compete with the enantioselectivity and reactivity levels of enzymes, omitting the need for highly toxic organometallic catalysts or “strong” Lewis acids. The availability of enantiopure organic chemicals as well as the academic, industrial, environmental and economic benefits of organocatalysis has shown the importance of this field of research. The combination of more than one chemical transformation into a cascade sequence is also an expanding area of research due to the reduction in cost, energy and waste. The proposed outgoing phase project would further the development of a new enantioselective organocatalytic method, within the pioneering research group of Prof. David MacMillan at Princeton. The MacMillan group have consistently been at the forefront of organocatalysis research, and thus far have pioneered over 30 catalytic asymmetric transformations of immense practicality and synthetic utility. The return phase project would highlight the importance of domino reaction sequences in organic synthesis today, with the implementation of a 3-step cascade in the total synthesis of an anti-cancer molecule. The mobility, importance of the research topic and high profile collaboration between 2 world-class research institutes would increase scientific excellence and provide opportunity to widely advertise participation in Marie Curie actions. Overall, a highly motivated European scientist would benefit grea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Accelerated quantification of photolytic hydrogen using multi-fidelity Bayesian optimization and automation' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The fossil fuel sector is projected to emit 200 million tons of CO2 equivalent by 2050. Hydrogen is emerging as a crucial energy carrier, essential for achieving net-zero emissions (NZE) by 2050. The European Commission is actively funding initiatives for decarbonization and green hydrogen production. Green hydrogen can primarily be produced through photocatalytic water splitting, involving either proton reduction or overall water oxidation. While several photocatalysts, predominantly inorganic or noble materials have been reported, recent advances in environmentally friendly nano-covalent organic frameworks (Nano-COFs) catalysts offer tunability and significant synthetic diversity. However, photocatalysts alone are insufficient for substantial hydrogen production. Multiple components must be integrated, such as co-catalyst selection, catalyst-to-co-catalyst ratios, and physicochemical parameters like pH and viscosity, to optimize hydrogen yield. The complexity of optimizing these parameters is challenging for manual testing, especially as the search space expands exponentially.  Self-driving laboratories (SDLs) are poised to revolutionize this field by leveraging advancements in robotics, computational power, and artificial intelligence (AI). SDLs can achieve scientific objectives hundreds of times faster than traditional automation, integrating hardware for experiment execution and software for data analysis and subsequent experiment design. Despite these advancements, the time-intensive steps of photolysis and gas analysis remain bottlenecks. This proposal addresses the challenge of accelerating the photolysis process beyond current SDL capabilities. By employing a multi-fidelity Bayesian optimization algorithm, I aim to reduce the frequency of crucial yet time-inten
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Physical principles in host-pathogen interactions' (PPHPI) under Seventh Framework.

assistant: **Objectives**

In recent breakthrough publications, I developed quantitative models of accurate chemo-sensing in biological cells, as well as obtained important insights into how cells engulf and eat other cells and particles. The novelty of these works is the merging of the natural sciences of physics and biology for discovering general, overarching principles in biology. Now I propose to bring my research to a new level by tackling host-pathogen interactions, irrespective of established disciplinary boundaries.While individual signalling pathways are often well characterised in different cell types, an integrative view is largely missing. For instance, the chemical environments of pathogens are generally uncharacterised such as occurring in complex bacterial communities in an host organism. Furthermore, the strategies of how our immune cells sense and hunt their bacterial prey remain unknown. Specifically, how do they sense minute chemical signatures left by bacteria? Once an immune cell encounters a bacterium, what are the determinants of successful engulfment and destruction of the pathogen? To address these questions, I will investigate how bacteria perceive their environment with cell-surface receptors, including what chemical stimuli and gradients their sensory systems have adapted to by evolution. I will identify the strategies of cells for achieving highly accurate sensing, and study the dependence of engulfment on bacterial cell shape, stiffness, and ligand density. Answering these questions is of fundamental importance since it would identify how infections arise, spread and are cleared, with pharmaceutical applications in near sight.To conduct this research, the ERC Starting Grant would allow me, by assembling a cutting-edge and creative research team, to consolidate my re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Simulation of Transport between the Adriatic Sea and the Danube' under Horizon 2020.

assistant: **Concept**

Even though transport had a bad reputation in the discourse of the Roman elites, in recent research it became evident, that it had a vital impact on the prosperity of the Roman economy and thus on the long-term existence of the Roman Empire. Therefore, it is an absolute desideratum to explore Roman inland transport transdisciplinary, combining recent technological developments with experimental data and profound historical research to gain the most realistic transport times. The objective of STRADA is the development of a dynamic computer-based simulation system for water and land borne transport between the Adriatic Sea and the Danube. Thereby, STRADA is geared to three aims: a) the study of the spatial and temporal interconnectivity between Roman Italy and the Danube frontier, for gaining a better understanding of the economic cohesion of the Roman Empire, b) the analysis of the influence of environmental factors on the ancient transport system, c) and the introduction of dynamic simulations into historical research. For the implementation, the project will focus on three closely interwoven strands: The exact reconstruction of the ancient land- and water-routes, the experimental determination of the performance of the used land- and water-borne means of transport under changing environmental conditions, and the development of a time-related simulation system including local fine granular topography and historical weather data, different means of transport (water- and land-based) with different loads, the fatigue of the actors as well as necessary rests and loading times.STRADA will follow a modular design that will ease the sustainable use and a future extension of the simulation system. The chosen research area covers a wide range of landscapes from the Mediterranean
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Establishment and Exploitation of a European-Latin American Research Consortium towards Eradication of Preventable Gallbladder Cancer', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Gallbladder cancer (GBC) is a neglected disease with huge potential for prevention. This project aims at significantly improving the accuracy of risk estimation and early detection of GBC by identifying and adequately considering geographical, environmental, lifestyle, ethnic, gender and molecular differences. We plan to generate the information needed to establish and refine current prevention programmes, including the primary, secondary and tertiary prevention of GBC. We will (1) build a unique European–Latin American GBC biorepository integrated into a tailored IT platform, (2) identify, validate and functionally characterize novel GBC biomarkers, (3) develop a multifactorial risk score that integrates established and newly identified epidemiological and molecular risk factors, (4) improve the understanding of the causal mechanisms that link lifestyle, cultural and behavioural factors to GBC development, (5) unravel novel opportunities for the targeted therapy of incidental GBC, (6) exploit existing and newly generated epidemiological and multi-omics data to improve the accuracy of GBC risk prediction and (7) contribute to the training of the next generation of Latin American researchers in precision medicine for GBC. The generated information will permit identification of individuals at high GBC risk, guiding surveillance and individual decisions on the possible benefit of preventive gallbladder removal in regions of low and high GBC incidence. Novel data on genomic alterations in incidental GBC will pave the way towards implementation of future clinical trials. The planned European–Latin American GBC biorepository and IT platform will constitute a prime resource for translational research on individualized prevention, personalized early detection and targeted thera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Concepts, theories and models for planning , operating and evaluating the dynamics of Mobility as a Service', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Online marketplaces enable in the travel context the dynamic matching of supply and demand. The shared economy can revolutionize urban mobility by blurring the traditional division between private and public transport, shifting from an ownership model to Mobility as a Service (MaaS).Existing transport models are designed with the premise that transport consists of either fully scheduled and controlled fleets or individual privately owned vehicles. Since MaaS breaks the conventional division between individual (ownership) and collective (usage) travel alternatives, existing theories and models of travel behaviour, transport network and operations cannot explain the behavioural dynamics, interactions and evolution of both supply-side and demand-side of the marketplace.This research program develops and tests theories and models of transport network in the domain of two-sided mobility market.  CriticalMaaS will produce a set of new behavioural models of traveller and supplier choices in transport marketplace settings. The supply- and demand-side dynamics and their interactions will be mathematically formalized and developed in both network flow distribution and agent-based modelling frameworks designed for the analysis of their co-evolution. Models will be used to study emerging patterns, transition phases and critical mass concepts by testing the conditions required for generating economies of scale in market adoption and evolution of MaaS. Models will be estimated and validated using a series of surveys, choice experiments, laboratory experiments, observed behavioural data from on-demand services, focus groups and interviews.The proposed research efforts will result with several theoretical and methodological breakthroughs in the field of transport modelling. In addition
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Smart MEMs Piezo based energy Harvesting with Integrated Supercapacitor and packaging' in the context of a Horizon 2020 call.

assistant: **Objectives**

Smart-MEMPHIS project addresses the increasing demand for low-cost, energy-efficient autonomous systems by focusing on the main challenge for all smart devices - self-powering. The project aims to design, manufacture and test a miniaturized autonomous energy supply based on harvesting vibrational energy with piezo-MEMS energy harvesters. The project will integrate several multi-functional technologies and nanomaterials; lead-zirconate-titanate materials in MEMS-based multi-axis energy harvester, an ultra-low-power ASIC to manage the variations of the frequency and harvested power, a miniaturized carbon-nano material based energy storing supercapacitor, all heterogeneously integrated with new innovative flat panel packaging technologies for cost effective 3D integration verified through manufacturability reviews.The performance of the system will be demonstrated in two demanding applications: leadless bio-compatible cardiac pacemaker and wireless sensor networks (WSN) for structure health monitoring (SHM). For the pacemaker, a smart energy autonomous system will accelerate the paradigm shift from costly, burdensome surgical treatments to cost-effective and patient-friendly minimally invasive operations enabled by leadless pacemakers capable of harvesting energy from the heart beats. The key challenges for the energy harvesting arise from the extremely stringent reliability requirements, the low vibrational energies and frequencies and the small size required for a device implanted inside a heart.With the 2nd demonstrator the consortium consisting of multi-functional value chain will show a wider applicability for the technologies complementing the medical application. A WSN with acoustic sensor nodes will be demonstrated in SHM applications. SHM enables real-time monitor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Monitoring and control of corrosion in water distribution systems', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

This project will develop new advanced sensor and control devices to monitor and control corrosion, leakage and water quality in water distribution systems. The product will develop intelligent analysis techniques for data fusion, analysis and interpretation of multi-sensor information to give useful information to water distribution system operators. The integrated system will also provide in-situ control of the corrosion process using the multiple-sensor data model to advance control techniques in this area.