RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel natural products for healthy ageing from Mediterranean diet and food plants of other global sources' (MediHealth).

assistant: **Innovation**

The main goal of the MediHealth project is to introduce a novel approach for the discovery of active agents of food plants from Mediterranean diet and other global sources to promote healthy ageing. This will be achieved through an extended and well-balanced scheme of researcher’s secondments between 5 universities and 4 enterprises from EU & Associated countries as well as 4 universities from Third countries. A mutual scientific project developed on the needs and interests of both sectors exploiting the existing complementary expertise will be the base of this proposal. Plants from the Mediterranean diet and food plants from TC will be rationally selected and will be subjected to an integrated, interactive and comprehensive platform including in silico, in vitro (advanced cell-based assays), in vivo (flies and mice models) & metabolism assessment. Advanced analytical techniques will embrace the pharmacological evaluation process for the efficient isolation and identification of bioactive plant constituents. Pharmacological profiling of bioactive natural products as well as identification and synthesis of their metabolites will be carried out. Finally, to carry to the stage of development innovative products in the area of nutraceuticals/dietary supplements process-optimization studies will be performed. Within this project, core scientific multidisciplinary knowledge from different research areas will be integrated creating valuable synergies. Expertise will be transferred by means of the seconded researchers training in environments with different research orientation where complimentary skills are required. Special attention will be given to dissemination activities aiming to public awareness of benefits of healthy diet(s). MediHealth aspires to comprise a successful
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Warwick Interdisciplinary Research Leadership Programme' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The Warwick Interdisciplinary Research Leadership Programme (WIRL) is a major new initiative by the University of Warwick to train future generations of Research Leaders in Europe. Warwick is known for its experience in interdisciplinary postdoctoral training through its leading Institute of Advanced Study (IAS), its innovative cross-sectoral research carried out through its ten Global Research Priorities (GRPs) and its international environment and reputation created through distinctive global partnerships and research collaborations. WIRL will build on this background to train 30 international researchers over five years to form a group of New Research Leaders who will contribute to the European Union’s plans to build a dynamic, knowledge-based economy and to improve economic growth. Warwick’s experience shows that Research Leadership is greatly enabled through close mentoring, international collaborations and the opportunity to build an independent research profile within the first five years of post-PhD research. Since 2007 the IAS has hosted a well-established research development programme, delivering complementary skills training to early career and experienced researchers.  WIRL will be a major step forward in Warwick’s Postdoctoral training programme. It will expand the current UK-centred programme into one with a pan-European focus and global reach. WIRL will create an environment for Fellows to develop the skills and gain the experience required to become Research Leaders in their fields within and beyond academia. This research environment is underpinned by the University’s 10 interdisciplinary GRPs that sit across academic disciplines, representing Warwick’s key areas of research excellence and engagement. GRPs bring together research strengths from across
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Engineering Extracellular Matrices for Controlling Structure and Dynamics of Lipid Bilayer Membranes' (EXTREME).

assistant: **Concept**

Cell membrane is the most critical element that is common to all biological systems. This five-nanometer-thick highly flexible lipid bilayer is known to govern numerous vital cellular processes including endocytosis, exocytosis, enzyme activity, ion transport, cell-cell communication and cell division. Understanding and controlling multiscale structure and dynamics of the cell membrane is, hence, the key to regulate these crucial activities. So far, proposed approaches to tuning membrane dynamics, leading to its fluidity and stiffness, are based exclusively on modification of the bilayer composition that is highly cell specific. In this project, the researcher will use his previous research experience in harmony with expertise of the supervisor to uncover a novel and mechanistic way for regulating the dynamics of the lipid bilayers via engineering complex extracellular microenvironment. Beside its highly interdisciplinary and fundamental nature, this research has a significant potential to open up a new practical pathway to cure membrane-associated diseases, including but not limited to type-2 diabetes, cancer and Alzheimer. This research action will be a great opportunity for the researcher to acquire new scientific expertise, grow his worldwide collaboration network, practice key project management skills and effectively disseminate research outcomes - all of which are essential for being a successful independent academic.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Performances as Highly Enriched aNd Interactive Concert eXperiences' in the context of a Seventh Framework call.

assistant: **Objectives**

Modern digital multimedia and internet technology have radically changed the ways people find entertainment and discover new interests online, seemingly without any physical or social barriers. Such new access paradigms are in sharp contrast with the traditional means of entertainment. An illustrative example of this is live music concert performances that are largely being attended by dedicated audiences only. The PHENICX project aims at bridging the gap between the online and offline entertainment worlds. It will make use of the state-of-the-art digital multimedia and internet technology to make the traditional concert experiences rich and universally accessible: concerts will become multimodal, multi-perspective and multilayer digital artefacts that can be easily explored, customized, personalized, (re)enjoyed and shared among the users. The main goal is twofold: (a) to make live concerts appealing to potential new audience and (b) to maximize the quality of concert experience for everyone.<br/>Scientific objectives of PHENICX are (i) to generate a reliable and effective set of techniques for multimodal enrichment of live music concert recordings suitable for implementation and deployment in real-world situations, and (ii) finding ways to offer the resulting multi-faceted digital artefacts as engaging digital experiences to a wide range of users. The project will establish a methodological framework to map these scientific objectives onto a solid implementation platform that will be developed incrementally and tested in real-life use settings.<br/>PHENICX will mainly focus on classical music - a European heritage asset that suffers heavily from an image of inaccessibility to outsider audiences. However, findings from PHENICX will be relevant to live concert situation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The first Galaxies' (EGGS), addressing dissemination and exploitation.

assistant: **Impact**

The goal of this project is to discover the first galaxies that formed after the Big Bang. The astrophysics of galaxy formation is deeply fascinating. From tiny density fluctuations of quantum mechanical nature believed to have formed during an inflationary period a tiny fraction of a second after the Big Bang during structure slowly formed through gravitational collapse. This process is strongly dependent on the nature of the dominant, but unknown form of matter - the dark matter. In the project proposed here I will study the epoch of first galaxy formation and the subsequent few billion years of cosmic evolution using gamma-ray bursts and Lyman-α (Lyα) emitting galaxies as probes. I am the principal investigator on two observational projects utilizing these probes. In the first project, I will over three years starting October 2009 be using the new X-shooter spectrograph on the European Southern Observatory Very Large Telescope to build a sample of ~100 gamma-ray bursts with UV/optical/near-IR spectroscopic follow-up. The objective of this project is to measure primarily metallicities, molecular content, and dust content of the gamma-ray burst host galaxies. I am primarily interested in the redshift range from 9 to 2 corresponding to about 500 million years to 3 billions years after the Big Bang. In the 2nd project we will use the new European Southern Observatory survey telescope VISTA. I am co-PI of the Ultra-VISTA project that over the next 5 years starting December 2009 will create an ultradeep image (about 2000 hr of total integration time) of a piece of sky known as the COSMOS field. I am responsible for the part of the project that will use a narrow-band filter to search for Lyα emitting galaxies at a redshift of 8.8 (corresponding to about 500 million years af
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'SkyLight: Innovations in titanium investment casting of lightweight structural components for aero engines' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Project SkyLight is proposed by AMRC Castings (which evolved out of Castings Technology International).  AMRC Castings, a department of the University of Sheffield (USFD), is part of the UK’s High Value Manufacturing Catapult.  AMRC Castings’ mission is to develop and disseminate casting technology to the benefit of the cast metal and manufacturing sectors.  Based on the Topic Description, and on AMRC Castings’ long experience of similar projects, we believe that project SkyLight would enable the investment casting process to deliver greater geometrical complexity, reduce defects by 50%, optimise stiffness, and deliver weight saving of 15% to 30% and cost saving of 30% compared to conventionally fabricated multi-piece assemblies, along with significant environmental benefits for both the manufacturing and the use phase of the component.  AMRC Castings helped Sulzer to achieve an improvement in pump absorbed efficiency - saving 10% on the power demand.  AMRC Castings’ Patternless® process helped Rolls-Royce reduce the time from CAD model to prototypes from 6 months to 6 weeks, and developed more accurate naval propellers for the VT Group that are seen as setting a new standard for others to follow.  AMRC Castings’ MEGAshell® process enables ceramic moulds with dimensions of up to 2m3 to be manufactured so that heavy section valve castings weighing several tonnes can be manufactured 34% lighter than the sand cast equivalent and reducing machining costs by over 50%.  This year, AMRC Castings is installing what is believed to be the largest furnace for casting titanium aerospace components in Western Europe - a 1000kg titanium melter - to complement its existing state-of-the-art casting facilities.AMRC Castings has participated in 21 EU-funded collaborative research project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New, stable, ruthenium based asymmetric epoxidation catalysts' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content Enantiopure epoxides are important intermediates for the pharmaceutical industry. Present production methods rely on kinetic resolution. This causes destruction of the unwanted isomer which leads to unnecessary waste. Better production methods rely on asymmetric synthesis where only one enantiomer is produced in the epoxidation step. Current state of the art is a manganese based catalyst developed by E. Jacobsen (Harvard university). Trials with this catalyst for the industrial production of epoxides led to the conclusion that instability of the catalyst under the epoxidation conditions gave rise to low turnover frequency and hence poor economics of the process. There is therefore a clear need for new stable asymmetric epoxidation catalysts. I propose to prepare catalysts based upon ruthenium complexes made with robust ligands with proven oxidation stability. Two classes of ligands will be explored. The first class is based upon extremely stable triazole dicarboxylic acid, in combination with enantiopure 1,2 diaminocyclohexane. The other ligand class will be based upon enantiopure varieties of 2,2'-bipyridine 3,3'-dicarboxylic acid. With these new catalysts I will explore epoxidation of a range of olefins with industrial relevance, such as substituted styrenes, cinnamic acid derivatives, indenes and chromenes. Training content (objective, benefit and expected impact) Training aspects will be abundantly present in the form of exposure to the industrial context, working in a team that routinely works on similar problems from exploratory research via route scouting and process development till large scale production in the plant. I expect to gain a much better insight in the way in which industrial research works. This will aid me in obtaini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Constantius in Context: Reshaping the Roman Empire' (CONSTANTIUS2) targeting Seventh Framework.

assistant: **Abstract**

The reign of the Roman emperor Constantius II (337–361) was instrumental in shaping early models of a united Europe. Constantius presided over religious controversies regarding the definition of Christian orthodoxy and the role of the state in ecclesiastical affairs, and a substantial reorganization of the political, administrative and military aspects of the empire. His reign shaped the state which was to become the Carolingian empire in the west and the Byzantine empire in the east.In the absence of Constantius’ own writings, the literary source tradition for his reign, represented by secular and ecclesiastical writers, is the most complex and hostile towards a single emperor in Roman history. It is characterised by a range of traditional yet developing literary genres which articulate the religious and political anxieties of their age and have obscured Constantius’ role in this formative period of European history. Using theoretical approaches developed within the field of classical literary studies, this project will investigate:(1) how the presentation and reception of Constantius developed in the source tradition between his accession and the mid fifth century;(2) what the shifting critical framework within which these authors judge Constantius tells us about the changing nature and understanding of the imperial office in Late Antiquity;(3) to what extent the literary presentation of Constantius may be reconciled with information derived from laws, inscriptions and numismatic evidence, which illuminate his overhaul of the administrative and legalistic role of the emperor.The outcomes will contribute to several objectives of the ERA and Horizon 2020. Together with creating intra-European collaborations, the scientific outcomes will provide an enhanced interpretatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Context-Active Resilience in Cyber Physical Systems'.

assistant: **Concept**

This European Fellowship project will benefit the researcher by giving and enhancing the knowledge and skills for a future generation of CPSs which enjoy the unique feature of context-active resilience. With such new capability and training, the researcher is expected to realise his potential and gain his leading role at international level in CPS research community. Context-active resilience is a novel concept of CPS resilience proposed in this action, which emphasises active and even proactive response to the dynamic state of CPS and its users in real-time. CAR Patterns will be identified via the empirical analysis of practical CPS systems, and specified with the developed Meta-Intelligence and populated into a semantic repository. Due to the wide and critical roles of CPS in industry and society and the novelty of context-active resilience, the proposal is both timely and significant. Acting as a bridge, the project will simultaneously advance the theoretic approach and art of practice of this emerging topic, improve the competency and career of the fellow, enhance and complement the host’s research profile and infrastructure, and benefit the society, living, economy and related research communities significantly.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Broaden Research Infrastructures – Deepen the Geography of Europe', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The project BRIDGE (Broaden Research Infrastructures – Deepen the Geography of Europe ) is aiming at organizing the celebrating of the the 20 years of ESFRI through a 20 Years Anniversary ESFRI Cconference. The Cconference  will take place in France, under the aupices of the French Presidency of the Council of the European Union, on March 25th, 2022. The heardquarters of the French Academy of Science, at Institut de France, 23 quai de Conti, 75006 Paris, will be the main venue for this event. The objectives of the project are the following:•Valorisation of the impact of ESFRI on European R&I system over the 20 years•Reinforcement of the role of ESFRI and the European RIs in the renewed ERA•Increased awareness of the research and innovation actors of the opportunities provided by European RIs


**Keywords:** research infrtastructures, ESFRI, services, access, valorisation, innovation, science policy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Regulation of stage conversion in the malaria parasite: molecular insights for novel vaccine strategies' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Infection of the liver by Plasmodium parasites, the causative agents of malaria, is an essential and clinically silent phase that constitutes an ideal target for anti-malarial prophylactic approaches such as vaccines. After inoculation in the skin by a mosquito, Plasmodium sporozoites migrate to the liver and invade hepatocytes, where they differentiate into liver stages and thousands of pathogenic merozoites. Liver stage-infected hepatocytes are potential targets for protective CD8 T cells elicited after immunization with live attenuated sporozoites, but the target antigens remain to be identified. We have previously identified a master regulator of Plasmodium liver stage development, named SLARP, which regulates gene expression during parasite stage conversion. SLARP-deficient parasites show a complete developmental arrest in the liver and, interestingly, confer poor protective immunity in rodent malaria models. We have recently generated a list of genes that are regulated by SLARP and may be involved in liver stage development and protective immunity. The objectives of this proposal are 1) to use a medium throughput reverse genetics approach to analyze the role of these genes during stage conversion, and 2) to investigate the molecular basis of SLARP-dependent gene regulation. One major roadblock for the development of pre-erythrocytic immune intervention strategies is the remodeling of the parasite antigenic make-up during stage conversion upon host switch. Generation of parasite lines with defined defects in stage conversion, ranging from early transformation to onset of DNA replication and parasite growth, will aid in prioritizing candidate protective antigens, which together can elicit lasting protection against reinfection. Furthermore, a better understanding at