RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sex differences in intestinal plasticity' (IntraGutSex) under Horizon 2020.

assistant: **Objectives**

Sex differences in intestinal plasticityMales and females often differ in their physiology and disease susceptibility. Sex hormones play key roles in sculpting and maintaining such sex differences, but increasing evidence points to a contribution of cell-intrinsic mechanisms. We are only beginning to understand the molecular mediators of these intrinsic mechanisms, and little is known about the organs where they function and their effects at the whole-organism level. Our work in flies recently revealed the existence of intrinsic sex differences in intestinal stem cell proliferation. This work raised the possibility that other, more metabolically significant intestinal cell types have their own sexual identity, with potential consequences at the organ and whole-organism levels. This proposal will explore the nature and significance of this sexual identity in two such cell types: enterocytes and neurons.We will first take advantage of our ability to genetically manipulate and sexually transform these cells in Drosophila in order to understand how their sexual identity is specified and whether it needs to be actively maintained. We will then explore the contribution of such sexual identity to organ features and whole-body physiology. Finally, we will investigate the evolutionary conservation of our findings by establishing organoids as a model to investigate enterocyte physiology, and then use them to explore whether intrinsic mechanisms are also active in the mouse intestinal epithelium. Collectively, our multidisciplinary approach will shed light on the contribution of the intestine - an organ not previously known to have an intrinsic sexual identity - to sex differences in physiology. It will also pioneer the study of enterocyte physiology in organoids: an emerging and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Developments of perinatal technology and ethical decision-making during pregnancy and birth: the obstetricians' perspective' (1994-1998).

assistant: **Concept**

OBJECTIVESTo explore obstetricians' views, attitudes and self-reported practices regarding ethical decision-making in perinatal care, with special reference to:- situations of conflict of rights between mother and fetus- therapeutical decisions at birth for extremely premature or malformed newborns; - communication with the parents-to-be and the neonatologists in comparison with the views and practices reported by the neonatologists within the framework of a previous European concerted action (EURONIC).While ethical issues in perinatal care have been widely discussed in the literature from a theorethical point of view, the empirical evidence about physicians' actual opinions and behaviours is scarce and fragmented. By collecting comparable information across different European countries and cultures, this study will provide a clearer understanding of the decision-making patterns, and sounder knowledge upon which both individual choices and policy setting might be based.The overall objective of this project is to explore the obstetricians' views, attitudes and self-reported practices regarding ethical decision-making in perinatal care, with special reference to:1. situations of conflict of rights between mother and fetus;2. selective non treatment decisions at birth for extremely premature or malformed newborns;3. communication with the parents-to-be and the neonatologists in relation to the legal and ethical background of the participating countries and in comparison with the views and practices reported by the neonatologists within the framework of a previous European C.A. project (EURONIC).To meet this objective, it will be necessary to describe:a. The obstetrics departments where the ethical decision-making process takes place: structure, organization, workload and p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Real cost reduction of door-to-door inter-modal transport' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

RECORDIT will:1) design a comprehensive methodology for the calculation of real (internal +external) costs of intermodal freight transport and for the understanding of cost formation mechanisms,2) validate this methodology through its application to three meaningful European corridors (including CEEC),3) analyse current charging and taxation systems to understand price formation mechanisms,4) carry out a systematic cost comparison for intermodal and all-road alternatives5) assess current imbalances and inefficiencies,6) develop a decision support module to foster generalisation,7) identify and analyse technical and organisational cost reduction options,8) formulate recommendations on public policies and business actions to reduce real costs and to internalise external costs,9) promote consensus building among operators and users,10) disseminate project findings (2 workshops, a website).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Understanding the Energy Transition with a Machine Learning Toolbox' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The goal of this proposal is to build tools to better understand the economic impacts of the rapid transformation of electricity markets, and to help better design electricity markets going forward. I propose to develop and implement novel statistical tools and structural models that contribute to our understanding of this rapid transformation. The proposed research focuses both on firm strategic responses and investment (supply-side), as well as consumer behavior and welfare and distributional impacts (demand-side). The proposal presents several projects and methodologies that examine these issues in detail with unique high-frequency micro-data on firms and households.  The tools and models developed in this proposal can help understand the impacts of the energy transition, both on the supply and the demand side. Among the expected methodological contributions, I plan to combine machine learning tools with more standard structural modeling. On the supply side, the proposal emphasizes the need to understand how strategic behavior interacts with market design in the presence of intermittent resources. On the demand side, the proposal highlights the importance of understanding the distributional implications of such changes with special attention to the residential sector and the most vulnerable socio-economic households.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'MEMBRANE PROTEINS OF ELECTROACTIVE BACTERIA PROBED AT LIPID LAYERS ONTO MODIFIED ELECTRODES'.

assistant: **Objectives**

MELBA aims at developing an efficient and versatile electrochemical platform for probing the charge transfer properties, electronic or protonic, of membrane proteins extracted from Gram negative electroactive bacteria. This 2 years research project will be conducted at the Université de Rennes 1, UR1 France, including a six months Secondment at Universidade Nova de Lisboa, UNL Portugal. Carbon electrodes will be covalently modified with pH-responsive electrophores through surface modification techniques, WP1 Task1. Lipid layers will be deposited onto the modified electrodes to create an artificial membrane as a host for extracted membrane proteins, WP1 Task2. The experienced researcher Dr. Lebègue will learn protein expression, extraction, purification and characterization during the six months Secondment at UNL, WP2 Task3. Finally extracted proteins will be incorporated into the artificial membrane deposited onto the modified electrodes and their electronic and/or protonic charge transfer properties will be characterized, WP2 Task4.The ambition of MELBA is to understand the coupling of extracellular electron transfer with proton transport in Gram (-) electroactive bacteria. The outcome of MELBA will be useful to optimize potential microbial electrochemical technologies based on electroactive bacteria and will be applied to the characterization of the charge transfer properties of any membrane protein. Within MELBA, 3 oral communications will be given at international conferences, 5 high impact papers will be published in the field of bioelectrochemistry and 5 formal public engagement actions have been scheduled. MELBA will allow Dr. Lebègue to develop and extend her expertise in electrochemistry, materials science and surface modification to microbiology and biochemist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Antibiotic resistance surveillance & control in the mediterranean region' under Fifth Framework.

assistant: **Concept**

EU Council Resolution 1999/C 195/01 A strategy against the microbial threat" highlights antibiotic resistance as a major challenges facing public health and identifies the need for surveillance of antibiotic resistance, adherence to infection control principles and promotion of optimal antibiotic use. Numerous EU projects have been started in member states to address these issues, primarily European Antimicrobial Resistance Surveillance System. European Study on Antibiotic Consumption and the HARMONY infection control project. Although preliminary evidence indicates high resistance prevalence in the Mediterranean, such networks are still absent in the much of the region. ARMed will link with these European studies and extend them to non-participating southern and eastern Mediterranean partner countries. It will study the epidemiology of antimicrobial resistance, antibiotic consumption trends, infection control measures and disseminate results widely within the region."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Advanced maintenance and repair for offshore wind farms using fault prediction and condition monitoring techniques' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Main objective of the project is to lay the foundations for condition depending maintenance and repair (M&R) strategies for wind energy converters (WEC) in offshore wind farms. As a basis for such strategies, condition monitoring and fault prediction hardware and software has to be integrated into installation of farm technology.Within this project, comprehensive solutions for installation of the required sensor equipment in WEC will be worked out; existing condition monitoring and fault prediction techniques will be investigated relating to their applicability for use in WEC. New WEC specific techniques will be developed. Algorithms for condition depending M&R scheduling will be worked out. All software parts of the project will be designed as plug-in" components for existing products, e.g. for wind farm management tools."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'In vivo pathogen proteome profiling using selected reaction monitoring' (PATHOPROT).

assistant: **Innovation**

Bacterial infections represent a major and global health problem, which is further aggravated by the rapid and ongoing increase in antibiotic resistance. The limited success in the development of targeted therapies for particular invasive strains can be attributed to our limited knowledge how pathogens modulate their proteome homeostasis in vivo, knowledge that has so far remained elusive due to technical limitations.Here I propose the use of proteome-wide selected reaction monitoring mass spectrometry  (SRM-MS) for pathogen proteome profiling from samples obtained directly from in vivo using group A streptococci (GAS) as a model system. The proposal describes the use of SRM-MS to facilitate the construction of comprehensive and quantitative molecular anatomy knowledge models outlining spatial organization, pathway organization, absolute protein concentration estimations and interaction partners with host for complete microbial proteomes. Using the molecular anatomy as benchmark I intend compare how the proteome homeostasis is controlled in pathogens isolated directly from patients with different degree of disease severity to understand how disease severity, anatomical location and host dependencies effects the proteome homeostasis.The outlined proposal describes a generic strategy to provide comprehensive understanding of the pathogen adaption directly in vivo and represents a paradigm shift in the field of bacterial infectious disease. This proposal addresses central aspects within the medical microbiology field that has been long sought for but never studied due to technology limitations and will influence the development of the next generation targeted vaccine and therapeutic development programs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'TWINNING EXCELLENCE IN MANAGEMENT AND RESEARCH FOR GREEN ENERGY AND CHEMICALS USING SINGLE-ATOM CATALYSIS'.

assistant: **Objectives**

Our reliance on depleting fossil fuel reserves for energy, carbon feedstock, and chemicals poses significant threats to both our energy security and the environment. In response, there is a growing interest in seeking alternative, eco-friendly, and sustainable resources. Thus, international agreements and sustainable development goals set by the European Union and United Nations underscore the urgent need for a transition to a fossil fuel-independent and diversified carbon and energy economy. The MERGE project is dedicated to the valorisation of renewable carbon feedstocks ¬that do not compete with food and land resources–such as waste lignocellulose biomass derivatives. This valorisation is achieved through electro- or photo-catalytic reforming processes, resulting in the production of industrially essential chemicals and fuels. To address this challenge, MERGE project is focused on the development of environmentally friendly, recyclable, low-cost, and efficient cooperative and tailored single-atom catalysts. This endeavour leverages knowledge transfer between the research unit in Czechia and the top-class partners of the consortium. The ultimate goal of MERGE project is to cultivate a culture of excellence in research, strategy, management, and technology transfer to the widening-country partner. At the same time, MERGE will position the widening-country partner and all Twinning Partners as prominent contributors in the European landscape in the field of advanced and sustainable catalysts for green and technologically important chemicals, via a committed and deep alliance towards excellence, permeating all facets of research.


**Keywords:** Biomass valorisation; single atom catalysis; green chemicals; sustainable fuels; bio-fuels; research culture excellence; capacit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Strategies to strengthen scientific excellence and innoVation capacIty for early diagnoSIs of gastrOintestinal caNcers' (VISION) targeting Horizon 2020.

assistant: **Abstract**

Slovakia belongs to countries with the highest incidence of colorectal and pancreatic cancer in Europe. Therefore, the main goal of the VISION proposal is to strengthen the scientific excellence and innovative capacity of Biomedicinske centrum Slovenskej akademie vied (BMC SAV), in early detection of gastrointestinal cancer (GI). Creation of a strategic partnership between the coordinator from widening county, BMC SAV and four internationally-recognized institutions, Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung e.V. (FhG), Ramón y Cajal University Hospital Health Research Institute represented by Servicio Madrileno de Salud, (SERMAS), Ethniko Kai Kapodistriako Panepistimio Athinon (NKUA), and Norsk Institutt for Luftforskning Stiftelse (NILU) will enhance the credibility and recognition of BMC SAV in European research area. Transfer of knowledge and research ideas, sharing of know-how, expertise and best practices, together with the implementation of cutting edge-technologies, will contribute to the enhancement of high-quality translational cancer research at BMC SAV, particularly GI cancer. Collaboration and networking between VISION partners will accelerate the personal and professional development of early stage researchers and medical doctors, impact the rate of success in internationally competitive research funding and high-quality peer-reviewed publications. Involvement of VISION partners in mentoring and co-supervision of PhD will increase the quality of education at universities, mainly medical and natural science faculties. Moreover, regional and outreach activities supported by VISION will lead to enhanced public awareness of cancer and the importance of prevention.


**Keywords:** gastrointestinal cancer, early diagnosis, innovation, circ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of prototype equipment for humane slaughter of farmed fish in industry' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The overall objective of the project is to develop prototype equipment for humane slaughter of the selected farmed fish species, namely eel (Anguilla anguilla), tilapia (Oreochromis niloticus), sea bass (Dicentrarchus labrax) and turbot (Psetta maxima). Humane slaughter consists of stunning (rendering unconscious without avoidable stress prior to killing). Feasibility criteria rule out individual handling of the concerned species. The aim is therefore to develop prototype equipment for electrical stunning, as this can be applied to batches of fish in water.The proposed project will:- model electrical stunning so that the required parameters for effective stunning with high quality standards can be predicted for the selected fish species and other species- establish requirements for stunning of the species with respect to product quality and welfare- design, build four prototypes (one for each species) for electrical stunning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Single-molecule visualization of temperature adaptation in sub-cellular dynamics and organization across bacteria' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Most microorganisms lack homeothermic regulation which subjects them to unpredictable fluctuations in environmental temperature. Nevertheless, many bacteria and archaea can grow across a large range of up to 40C. Most biochemical reactions in bacteria occur in the highly crowded cytoplasm constituting a complex and dynamic interaction network of a cell. Temperature affects the rate of both intra- and intermolecular reactions, and large-scale perturbations by temperature could be disastrous to cellular function, homeostasis, and sub-cellular organization. It is still largely unknown, how temperature affects the properties of the cytoplasm and what the consequences to cellular processes are. The driving hypothesis of this project is that bacteria can actively modulate their cytoplasmic state to avoid the detrimental effects of temperature fluctuations.To test this, I have established cutting-edge super-resolution single-molecule tracking tools to directly observe molecule dynamics in live bacteria in real time. First, we will quantify the diffusion and activity of macromolecules and other probes as a function of temperature to uncover the changes in the cytoplasmic state. Second, we will probe different bacteria growing at temperatures from 0C up to 100C to characterize evolutionary differences in the cytoplasmic dynamics and temperature scaling of reaction rates. Finally, we will uncover mechanisms by which bacteria obtain different cytoplasmic properties. Overall, these approaches will reveal how the cytoplasmic state in bacteria changes with temperature and how this contributes to the cellular processes, which has significant implications on how microorganisms adapt to temperatures and what are the limits of cellular life.


**Keywords:** single-molecule tracking, extr