RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mechanism of cellular IRESes translation' in the context of a Seventh Framework call.

assistant: **Objectives**

The central importance of translation control in cancer is just beginning to be fully appreciated. Translation normally initiates with the recruitment of the initiation factors to the 5’ cap of the mRNA for ribosome binding. Curiously, some normally capped cellular messages, which are involved in cell-cycle control, growth and apoptosis, rely alternatively on an internal ribosome entry site (IRES) at their 5’ end and the 3’ poly(A) tail to support translation. The advantage conferred by the IRES is obvious during shutdown of cap-dependent translation: these mRNAs remain bound to the polysomes and maintain steady expression. The deregulation of such mRNAs is directly implicated in tumorigenesis and clearly links translation to cancer. The precise mechanism of translation via cellular IRES and its regulation, the structural/sequence consensus, and its use remain largely unexplored. Here, using the pro-oncogenic c-myc IRES as model, we propose to investigate the role of the 3’poly(A) tail and the possible involvement of distinct set of regulatory factors for the IRES activity, which does not require the canonical poly(A) tail partner, PABP. We will use innovative functional proteomic approaches, which include capturing the RNP complex formed during ribosomal recruitment, and the establishment of high throughput siRNA-based in vivo and in vitro screening assays. Upon completion of the project, we will have a functional understanding of how the poly(A) tail enhances ribosome recruitment in a non-canonical fashion. These results will enable us to gain insight on mechanistic details of translation control. This research will contribute in EU excellence and competitiveness by covering a key area of basic biological process with a strong interest for Europe for its clear relevan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CIRCULAR ECONOMY INNOVATIONS FOR RESILIENT,  COMPETITIVE AND SUSTAINABLE BATTERY TECHNOLOGIES' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The CIRCUBATT project aims to redefine the European battery sector by setting new benchmarks through the integration of artificial intelligence, data analytics, and sustainable practices. By tackling critical bottlenecks and employing cutting-edge technologies, CIRCUBATT seeks to boost the competitiveness of the European industry while aligning with the EU’s environmental and economic objectives. Its holistic approach promises a more efficient, reliable, and sustainable battery value chain, prepared to address Europe's future energy demands and the global challenge of climate change.The project combines advanced material sciences, innovative business models, and leading digital technologies to deploy a range of solutions tested across various real-world scenarios. These solutions will span the entire battery lifecycle—from design and manufacturing to end-of-life recycling—showcasing adaptability, efficiency, and sustainability in practical applications. This initiative aims to reduce Europe’s reliance on critical raw materials, diminish environmental impacts, and strengthen the continent’s position in the global battery market.CIRCUBATT will explore innovative business models, such as Battery-as-a-Service (BaaS) and develop cross-industry tools like battery sustainability analysis and artificial intelligence-driven data analytics. Additionally, it will advance the design of battery cells and packs that support effective aging analysis and facilitate dismantling for second-life use or recycling. Pilot studies within the project will validate the feasibility of these innovations.Ultimately, the project will deliver new products, business models, and tools poised to make significant contributions to the circularity, resilience, and sustainability of the European battery va
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'FibRestoration - Novel specialized probiotics for restoring a healthy  fiber-degrading microbiome' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Dietary fiber is well-recognized as beneficial to gut microbiome and has repercussions on human health. Consequently, in recent years, alternative dietary lifestyles favoring the consumption of high amounts of dietary fibers have been proposed. In order to avoiddigestive discomfort associated with the increased intake of dietary fiber, we propose to develop probiotics that will target cellulose, the main component of dietary fiber. Indeed, cellulose-degrading bacteria are absent both in gut microbiomes of most human populations and in existing probiotics. During our proposed project, we will isolate unique fiber-degrading bacterium and restore it in the human microbiome via administration of probiotics. Thus, our products will comprise this bacterium either alone or in combination with other fiber-degrading strains and will augment the fiber-degrading potential of the human gut microbiome with concomitant implications in human health. Such probiotics will address the majority of global human populations and will constitute a niche in the global probiotics market, which is projected to further increase in the next decade.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High volume production facility for high accuracy nanocapsules' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The overall objective of NANOHIGH is the deployment in the market of an innovative technology for the production of high accuracy fibered/spherical-shaped nanocapsules based on principles of ElectroHydroDynamics (EHD). This technology, known as Coaxial EHD, enables the cost-effective manufacture of high accuracy capsules with special configurations and functionalities, which can be used for the controlled delivery of active compounds in multiple applications. The performance of this patent protected technology has been demonstrated in a lab scale pilot; however, its derivative products have not fully entered the market due to the lack of industrial scale equipment, required for the market deployment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development and testing of innovative Cr Free solution for REmoval of Anodic Layers' (2014-2020).

assistant: **Concept**

In 2024 the use of hexavalent chromium (Cr(VI)) will be forbidden by REACH regulation. Many studies have been carried out to replace Cr(VI)-based coatings for lightweight metals such as aluminium and have resulted in the development of new protective layers (SAA, TSA, Cr(III)-conversion coating). However, the removal of protective oxide layers is still performed with Cr(VI)-based stripping processes. Cr(VI)-free stripping with NaOH leads to deterioration of the substrate if the process time exceeds the specification of the very narrow process window. The Cr Free REAL project aims to develop an innovative process for Cr free removal of anodic layers and conversion layers, which does not deteriorate the aluminium substrate within an applicable process window. Commercially available or literature mentioned Cr(VI) free stripping agents will be tested and evaluated.In the proposed approaches, it is planned to develop innovative acidic or alkaline stripping agents containing additives. Corrosion inhibitors (e.g. oxoanions, cerates, thiourea to prevent corrosive attack during the stripping process), accelerators (e.g. nitrates, glycolic acid to enhance the removal of the oxide layer), surfactants and complexants (to help obtaining a complete and uniform removal of the oxide layer and for increase of bath stability) will be employed. The best performing stripping process will be tested on six types of machined and cast aluminium alloys for removal of Cr(VI)-based and Cr(VI)-free protective layers. The experiments will be performed on lab scale and pre-industrial samples, including complex-shaped parts with a size up to 400*300*200 mm. Specimens which are re-treated with Cr(VI)-free anodic and conversion coatings shall exhibit a corrosion stability with no pits after 500 hours S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of New Nanotechnology Strategies for Surface Disinfection/Decontamination' under Horizon 2020.

assistant: **Concept**

In the next 50 years, an estimated 10 billion people will require food but microbial spoilage cause more than 50% of all fruits and vegetables to go to waste in the EU alone. Current disinfection techniques do not seem effective to curb food wastage and at this rate, feeding the future world population will impose challenges. Thus, the overall objective of NanoSurf is to develop a procedure for the decontamination and disinfection of food products and food contact materials using a combination of (1) plasma, (2) ultrasound and (3) nanoparticles with antimicrobial properties. All three individual technologies emerge as effective in disinfecting, decontaminating and preserving food from microbial spoilage. However, based to our knowledge, the integration of plasma, ultrasound and nanoparticles into one technology has never been described for decontamination/disinfection applications. A two step-procedure is envisioned with (a) an initial decontamination with plasma and/or ultrasound technology and then (b) under these conditions generate in situ a low concentration of antimicrobial metallic nanoparticles to deter microbial growth during storage conditions. The method will make use of either pure water as solvent or a gaseous phase, thus eliminating the need of environmentally toxic media, such as, alcohol and electroconductive additives. NanoSurf is expected to have numerous advantages over traditional decontamination/disinfection technologies because the synthesis of nanomaterials Nps will be produced in-situ. The advantage of the proposed technological solution is the ease of implementation, the selection of varied technological schemes for plasma-ultrasound treatment as well as the synthesis of nanoscale metal oxide forms by non-toxic doses in various proportions for d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Hydrogen Incorporation in Subducting Lithosphere after Dehydration Reactions' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Subduction zones play a fundamental role in the deep water cycle making the Earth unique among other terrestrial planets. During subduction dehydration of hydrous minerals produces a fluid phase. A part of this fluid phase will be recycled water back to the Earth’s surface through hydrothermal aqueous fluids or through hydrous arc magmas, whereas another part of the water will be transported to the deep mantle by Nominally Anhydrous Minerals (NAMs) such as olivine, pyroxene and garnet. The partitioning of water between these two processes is crucial for the understanding the deep water cycle which has profound implications for the rheology of the upper and lower mantle. However, the transition from hydrous minerals to NAMs has been very little explored and only rough estimations are available.The main thrusts of the project are (1) to undertake a series of novel experiments with hydrous mantle compositions using high-pressure experimental facilities to constrain the actual water contents that are recycled in NAMs in shallow subduction zones (1.5-5.5 GPa and <900ºC) and (2) compare the products with natural assemblages that underwent extensive dehydration during subduction (through antigorite and chlorite high-pressure breakdown reactions). Additionally this project will investigate the link between mechanisms of deformation and mechanism of hydrogen incorporation in NAMs and how they may affect the rheology of the incoming slab and uppermost mantle.This project will be arrange by assuming two years at Australian National University (outgoing host institution), during which experiments will be performed and natural rocks will be analyzed for trace elements and water contents, and one year at Géosciences Montpellier (Return host institution), where microstructural investi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Joint Advanced Severe accidents Modelling and Integration for Na-cooled fast neutron reactors' under Seventh Framework.

assistant: **Concept**

This project will support the ESNII (European Sustainable Nuclear Industrial Initiative) roadmap and the Strategic Research Agenda and the Deployment Strategy of SNETP (Sustainable Nuclear Energy Technology Platform) on the enhancement of Sodium-cooled Fast neutron Reactors (SFR) safety, especially towards a higher resistance to severe accidents.In the initiation phase of SFR core disruptive accidents, it is essential to investigate the impact of new core designs that may disperse core debris and minimize risks of core compaction. The available codes today have been developed in the 80’s. The objective is to develop a new European simulation code, ASTEC-Na, with improved physical models, accounting for results of recent LWR research, with modern software architecture and high flexibility to account for innovative reactor designs. It will be based on the ASTEC European code system, developed by IRSN and GRS for severe accidents in water-cooled reactors. This will allow to capitalize the state-of-the-art knowledge on SFR severe accidents.The code will evaluate the consequences of fuel pin failure conditions on materials relocation and primary system loads, and the source term produced by the migration inside the reactor of activated fission products and aerosols that may be released to the environment.The project will gather partners with strong experience on SFR safety and/or on ASTEC code. Specific SFR physical models will be developed, on the basis of outputs of the CP-ESFR FP7 project. After the elaboration of general specifications and of a validation matrix, the models will be developed, implemented into the code, validated vs. experiments (like past CABRI ones) and benchmarked with other codes. The further extension of ASTEC-Na to cover other parts of the SFR sever
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'At the roots of corruption: a behavioral ethics approach' in the context of a Horizon 2020 call.

assistant: **Objectives**

For many years, human cooperation has been praised as beneficial in organizational and personal settings. Indeed, cooperation allows people to develop trust, build meaningful relationships, achieve mutually beneficial outcomes, and strengthen bonding with one's group members. However, while the benefits of cooperation are clear, very little is known about its possible negative aspects. Such negative aspects include the potential emergence of unethical conduct among cooperating partners, or as termed here – corrupt collaboration. Such joint unethical efforts, benefiting (directly or indirectly) one or more of the involved parties, occur in business, sports, and even academia. Corrupt collaboration emerges when one party bends ethical rules (here: lie) to set the stage for another party to further bend ethical rules and get the job done, that is, secure personal profit based on joint unethical acts. We propose that corrupt collaborations most commonly occur when all involved parties gain from the corrupt behavior. The current proposal is aimed at unfolding the roots and nature of corrupt collaborations; their existence, the psychological and biological processes underlying them, and the settings most likely to make corrupt collaboration emerge and spread. Accordingly, the information gathered in the current proposal has the potential to change the commonly held conceptions regarding the unidimensional – positive – nature of cooperation. It will help create a comprehensive understanding of cooperation and, specifically, when it should be encouraged or, alternatively, monitored.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Non-canonical nucleoside incorporation into synthetic RNA-oligonucleotides: investigations towards the discovery of selective RNA-binding proteins' (OLIGOBINPRO), addressing dissemination and exploitation.

assistant: **Impact**

The increase of life expectancy around the world comes at the unavoidable cost of a rise in the occurrence of neurological diseases such as Parkinson’s as well as debilitating ones like cancer. These conditions prevent the possibility of a sustained quality of life and cost society vast amounts of money for the treatment and care of patients. It is the responsibility of scientists to find innovative methods of treating and eliminating these diseases, allowing for a healthier quality of life. Recently, RNA-binding proteins have been linked to biological processes leading to these diseases as well as the expression of genes relating to obesity. A plethora of natural chemical modifications in RNA fine-tune its structure, allowing for this specific interaction which regulates processes such as gene expression and the tuning of translation. Although these have been known for years, their binding proteins have not been systematically studied. The difficulty of the chemical synthesis of modified oligoribonucleotides represents the major bottleneck in this field. The overall aim of this project is to discover RNA-binding proteins which bind to the non-canonical modifications Am, Cm, Gm, i6A and ms2i6A which were identified in the mRNA of human cancer cell lines. These will first be synthesised and then incorporated into oligoribonucleotide strands mimicking natural mRNA. By incubating with cellular extracts, we subsequently aim to identify their binding proteins by tagging them with novel technologies and analysing them using mass spectrometric techniques. This project will inspire and offer unique training to Dr. Michaelides by exposing him to this multidisciplinary field where chemistry and biology meet, enabling him to embark on his own academic career. Furthermore, it will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deciphering the dialogue between intestinal macrophages and their tissular niches' to be submitted under Horizon 2020.

assistant: **Abstract**

Besides their role as immune sentinels, macrophages fulfil specific functions that are strictly related to their tissue of residence. As an example, the loss of gut macrophages is correlated with impaired crypt cells differentiation which might favour the establishment of chronic intestinal inflammation. Macrophage functions are known to be regulated by tissular niches that imprint the macrophage tissue-specific identity. However, little is known about the “feedback” role of the macrophage for the maintenance and function of its niche. I hypothesise that the loss of a given macrophage subset might imperil its microenvironment through the alteration of its niche cells function or maintenance. Unravelling this feedback mechanism is technically challenging. Current mouse models target macrophages themselves, inducing their rapid replacement by circulating monocytes and thus preventing their long term depletion. Here, I will take advantage of their dependence to a continuous provision of trophic factors by their niche to manipulate and study gut macrophages in a novel manner. First, I will unravel the composition of each gut macrophage niches in a global and unbiased approach by combining single cells and spatial transcriptomics. Next, I will determine the potential cellular sources of trophic factors in each gut niches. Once identified, I will use specific mouse models to delete the trophic factor in the candidate cells to induce a long term depletion of a given macrophage subset. Finally, I will unravel the function of macrophages to their niche by analysing in silico the niche cells transcriptome after macrophage loss to highlight potential molecular interactions between the macrophage and the niche that would induce the survival or differentiation of niche cells. They w