RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'New Catalytic Reactions using Sulfur Dioxide' (CATSO) under Horizon 2020.

assistant: **Objectives**

Sulfur dioxide is produced in millions of tonnes per annum, and represents an abundant and low-cost feedstock for chemistry. Despite a varied and useful range of reactivity as a reagent for organic synthesis, the use of sulfur dioxide as a feedstock for catalytic processes was extremely limited with only a handful of reactions reported before 2010. This is particularly striking when the wide occurrence of the sulfonyl motif is considered, as it features in a variety of useful organic functional groups such as sulfones and sulfonamides. Together these functional groups appear in an enormous range of intermediates and final compounds used in the pharmaceutical, agrochemical and fine chemical industries. In earlier work we have show that use of an SO2 surrogate, such as DABSO, allows a variety of catalytic reactions to be developed. The take-up of these reactions, particularly the catalytic methods for sulfinate synthesis from aryl halides or aryl boronic acids, has been significant, and these reactions are being used in industrial laboratories. This is a great start, but there are a number of limitations to the chemistry, as well as opportunities to develop exciting related chemistry that we believe will have significant impact. The vast majority of catalytic reactions developed employ Pd catalysts and pre-functionalised “activated” substrates, such as aryl halides, boronic acids, or diazonium salts. These are useful reactions, but the reliance on precious metal catalysts and activated substrates is limiting, both from a sustainability perspective, but also in terms of reactivity, as the majority of these reactions all proceed by 2-electron processes. Accordingly, the main objective of this Fellowship is to develop catalytic reactions for SO2 incorporation that employ mor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Discount Coupon Recommendation and Redemption System'.

assistant: **Objectives**

DICO(RE)2S is an SME European Consortium devoted to develop and deploy a coupon-based discount campaign platform that will exploit state-of-the-art information and communication technologies and processes for providing consumers and retailers/manufactures with a personalized and efficient environment for maximizing customer satisfaction and business profitability.The platform will incorporate a centralized social-network-type of virtual space from which retailers/manufactures and customers will offer and demand, respectively, specific discounts. A distributed network of coupon redemption points at both, on-line and physical stores, will provide the system with real-time information about the coupon redemption dynamics.The centralized virtual space can be accessed by customers via any mobile device as well as desktop computers, and coupons will be delivered in either digital or paper formats. The virtual space will provide users with and intelligent-search engine and recommender system as well as forum facilities for evaluating and commenting on previous coupon and discount experiences. An integrated opinion mining and information extraction module will provide useful information for improving the system’s searching and recommending capabilities as well as for offering retailers/manufacturers with real time reports and evaluation on specific discount campaigns. As the platform should allow customers and retailers/manufacturers to access the information in their native languages, in the first phase of the project, English and Spanish will be considered, and more languages will be incorporated as required by business growth and expansion.The distributed network of coupon redemption points will implement pattern recognition systems for reading and validating coupons as well
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sleep disorders in menauposal and postmenopausal ageing women: prevelance , biological mechanisms animal models , social aspects , treatment and prevention' under Fifth Framework.

assistant: **Concept**

Disorder of sleep lead to diminished quality of life, health deterioration and predispose to accidents. Prelevence of sleep disorders increases in the course ofageing. Especially ageing women are more often afflicted by sleep disorders thanmen, but the psychosocial and biomedical mechanisms that cause this disceprancyare unknow. The present project integrates basic, medical and social research to identify the factors leading to sleep disorders in angering women. The project surveys their prevalence and the extent of social, economic and medicalimpairment. Biological mechanisms of gender associated sleep disorders will be investigated by combining animal models and human experiments addressing sleep and circadian rhythms. We expect to define the psychosocial and biomedical factors underlying sleep disorders in ageing women. Based on these information strategies to prevent and treat sleep disorders in ageing women will be tested.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ground Based Structural & Systems Demonstrator Phase 3 - Component and sub-system manufacture' (2007-2013).

assistant: **Innovation**

The Natural Laminar Flow (NLF) aerofoil is a potential key technology for the next generation of aircraft, improving aerodynamic performance, and thus reducing drag, and hence emissions. Achieving these reductions would be a significant step towards reaching the ACARE goals for 2020, including a 50% reduction in CO2 emissions and an 80% reduction in NOx emissions.The requirements of a Natural laminar flow wing differ significantly from a conventional turbulent wing, requiring changes to both the architecture of the wing, the aerofoil definition and the detailed design and manufacturing concepts. The performance of a natural laminar flow wing requires very tight surface roughness and waviness tolerances and contamination free surfaces in the areas where laminar flow is to be maintained. NLF wings also require alternative Leading Edge (LE) moveable concepts, novel LE/Wingbox joints, and slender LE sectionsIn Phase 1 of the Ground Based Structure and Systems Demonstrator (GBSSD) programme, the problem of how to achieve an aerodynamic surface of sufficient quality to support natural laminar flow has been addressed by GKN.  .Phase 2 is being undertaken by GKN and involves the detailed design of the fully integrated LE zone and forms the basis for the further development of the concepts for the GBSSD.Phase 3 will involve the manufacture of all selected features, components and sub-systems that will enable the several functions of the LE assembly and sub-systems to be demonstrated. These features will be supplied to Clean Sky to support the assembly of a 4.5m spanwise section of leading edge installation, including components and sub-systems.  The demonstrator aims to validate that the Phase 2 LE design can be manufactured in realistic high rate and repeatable conditions appro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cross-national determinants of quality of life and health services for the elderly' (CLESA) targeting Fifth Framework.

assistant: **Abstract**

Because of the aging of the population, and the expected increase in health care demands, epidemiological data to be used to establish priority areas for interventions are most needed. This project will contribute to increase the knowledge of the predictors (socio-demographic, behavioural, psychological factors and chronic conditions) of major health outcomes, such as decline in functional status, institutionalisation, and mortality. It will allow the comparison of these of health services in six different countries in relation to the abovementioned health predictors and outcomes. The results should become instruments that contribute to a better quality of life for the aged people, allowing also the countries to better allocate their resources for health care.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Validation of Progranulin as Biomarker in Diagnostics and Prognosis of Sepsis' (Vaprosep) targeting Horizon 2020.

assistant: **Abstract**

Sepsis is a complex, systemic and inflammatory host reaction on an infection and with worldwide 1.5 million cases per year a health challenge. There is a strong need for a reliable biomarker like progranulin. Preliminary data prove that progranulin allows a highly sensitive and specific detection of sepsis, a monitoring of infection without time delay, prognosis regarding disease course and a differentiation between the infectious agent inducing sepsis. Economic advantages of progranulin as biomarker are the reduction of the length of stay in the ICU (500-1000€ / day) and avoidance of unnecessary antibiotic therapy (10-500€ / day). Thus, the hospital can improve patient care and reduce therapeutic costs by a progranulin measurement for 5-10€. A mean incidence rate of 0.094% results in a 12 million euro market in the US and EU. Based on intellectual property this market is available only for Mediagnost. Successfully validated, progranulin measurement will be introduced in third level hospitals in the EU. The subsequent strategic product development includes point of care and multiplex test systems. Mediagnost already has a technically validated test system for this biomarker available, therefore the overall objectives of this study are the clinical validation of progranulin measurement in sepsis and its implementation in clinical routine. Specifically, in phase I the economic potential of this biomarker is evaluated.These objectives are addressed during phase I in a feasibility study including market and cost analysis. Key opinion leaders in the EU are interviewed by a structured questionnaire to evaluate scientific solidity and market potential. In direct contact to EU Notified Bodies the best regulatory strategy is evaluated. Further, literature research will complete
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Glia, Smell, Food & Courtship in Drosophila'.

assistant: **Concept**

Odors are key components for sensory communication involved in behaviors such as social communication or food search. Recently, molecular receptors, neuronal architecture, physiological regulation, and behavioral consequences underlying these biological processes are starting to be revealed in an increasing number of animal models. But more and more breakthroughs are highlighting some unexpected results asking for deeper studies. The Drosophila melanogaster has proven to be a particular powerful tool to understand, to test, and to manipulate the complex neurogenetical interactions between molecular and cellular partners controlling such behaviors. We have shown that a subset of glia is mastering the activity of a population of neurons involved in chemoperception in Drosophila (e.g. glutamatergic neurons). We have also recently uncovered a striking molecular and neuronal architecture regulating courtship using food odors instead of classical pheromones in fruit flies. Our emerging team at the CSGA-UMR 6265 CNRS will expand these pioneer works to understand how glia and neurons are interacting to impact fly chemosensory choice. For this aim, we will develop powerful genetic tools in Drosophila to reveal and to manipulate the communication between glial cells and neurons in peripheral sensory organs and in projection centers in the brain. We will also look for conserved mechanisms in other insect species (mosquito). The expected data are susceptible to touch a large scientific public since olfaction plays a key sensory modality in most animal species. The collected data on glial function in neuronal activity control will have also a strong impact on finding new strategies to understand neuronal disorders in humans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Magnetic flow tomography in technology geophysics and ocean flow research' (MAGFLOTOM) targeting Sixth Framework.

assistant: **Abstract**

In quite distinct areas such as metallurgy, crystal growth, geophysics and ocean flow analysis there is a growing interest in contactless methods of flow velocity determination based on the inversion of induced magnetic field measurements. This applies to the industrial continuous steel casting, to modern silicon crystal growth under the influence of magnetic fields, to the determination of the liquid metal flow in the Earth's outer core and in dynamo experiments as well as to the magnetic sensing of ocean currents by satellites. Independent from each other, some of these topics have recently achieved a breakthrough, and all are based on sophisticated magnetic field measurements and velocity reconstruction techniques. The intention of the project is to bring together these disparate activities and to push them forward by using synergies between the different approaches.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Atomic Clusters and Nanoparticles' (1998-2002).

assistant: **Innovation**

Clusters are aggregates of atoms or molecules with a well-defined size varying from a few constituents to several tens of thousands. They are the link between single atoms or molecules on one side and bulk matter on the other side. They provide the keys that explain how conventional matter builds up step by step and eventually finds its crystalline structure, physical and chemical properties. By studying clusters we wish to answer such fundamental questions as to which size has a given bulk property being reached.Atomic and molecular clusters are actually another form of matter. The finite nature of the number of constituents leads to novel structural and thermodynamic properties having no equivalent in the bulk. In metallic clusters, the electronic states at low temperature consist of discrete, separated levels. This structure should modify considerably the optical, magnetic, and super-conducting properties compared to those of the bulk metal. Experimental measurements carried out in recent years confirm these special properties. The study of phase changes in clusters has revealed the full richness (and complexity) of finite systems: one observes rapid variations of thermodynamic properties but no discontinuity, and bands of phase coexistence rather than simple curves.Theoretical methods for describing all sorts of clusters have undergone rapid developments in recent years, whether these techniques are analytical or numerical. Nowadays it is possible to consider problems, both fundamental and applied, that were previously inaccessible. By combining techniques from statistical physics, and numerical simulation, we can thus understand why for instance certain substances become glasses while others evolve toward perfectly regular structures.There is today a need for bring
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ExploriNg Lightning Initiation and Gamma-ray High-energy emission in Thunderstorm ENvironments', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Lightning strikes earth 45 times each second, but we still don’t understand exactly what initiates it. The large electric fields in thunderclouds are also responsible for charged particle acceleration, ultimately leading to gamma-ray production. Energetic radiation is an essential component of thundercloud dynamics. Energetic radiation and lightning discharge appear tightly linked, but the nature of this link is yet to be understood. ENLIGHTEN posits a causal relationship between energetic radiation and lightning initiation.  Combining novel time-resolved gamma-ray imaging of thunderclouds with simultaneous lightning discharge imaging in the radio band, we aim to establish the causal mechanisms which initiate lightning and, in doing so, address one of the longest standing unsolved questions in atmospheric electricity. Overarching hypothesis: lightning initiation is triggered by electron avalanches conducive to gamma-ray production. To test this hypothesis, we identify three research objectives:1. Mapping the spatio-temporal evolution of intense large-scale electric fields in tropical thunderclouds. 2. Imaging in gamma-rays of the newly discovered sub-second gamma-ray transients - flickering gamma-flashes and glow bursts. 3. Quantify the runaway electron avalanche discharge co-located with lightning initiation. ENLIGHTEN will achieve its objectives with a methodology which combines: a) time-resolved gamma-ray imaging of thunderclouds, b) time-resolved lightning imaging in the radio band, c) use of a high-altitude research aircraft, d) data analysis and modelling. Thunderclouds are the birthplace of a large variety of particle and gamma-ray phenomena, not to be considered just exotic and rare, but intrinsic and fundamental for thunderclouds. With 3 million lightning per d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Reactions with cobalamins and their mimics : mechanisms, synthetic applications and relevance to human health' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Young researchers will be trained at the interface of chemistry and biology. Their principal training will be in one of the 8 expert groups of the Network, but every young researcher will spend at least 10% of their time in another group, primarily to learn new experimental techniques. He/she will also attend every 6 monthly Network review meeting and present on his/her research. Every young researcher will attend at least one specialized course per annum. The topics that will be covered in courses of 1 -3 days duration are presentational skills and report writing, intellectual property and patents, combinatorial and solid phase synthesis, nuclear magnetic and electron paramagnetic resonance, mass spectrometric techniques, protein crystallography, molecular toxicology, enzymology, molecular biology. An annual one-week Winter School will be held on the subject of chemical biology, when the young co-workers will meet experts from academic and industrial organizations outside the Network.