RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'THIckness determination via COHERENt TERAhertz detection' in the context of a Horizon Europe call.

assistant: **Objectives**

What better way to measure thin films than by using a material that is just one atom thick?Society requires materials in user products and infrastructure to function properly, which requires quality control through non-destructive testing, ideally without physical contacts. One particularly important quality test is the thickness determination of thin films, such as car paint, coatings of wind turbines, and different material layers in chips. Low-energy (sub)terahertz light offers several benefits over current techniques for non-destructive thickness determination, which are based on high-energy light or sound. However, current terahertz-based strategies typically require femtosecond lasers, which comes with several technology adoption barriers.In this project, we will develop proof-of-concept demonstrators for contactless, in-situ thickness determination of thin films that do not require femtosecond lasers. Our approach builds on our very recent demonstration of a graphene-based (sub)terahertz photodetector that simultaneously acts as an integrated interferometer. This enables the coherent detection of (sub)terahertz light and the determination of the thickness of thin films placed in the path towards the detector-interferometer.  The detector exploits the exceptional properties of hot electrons in graphene, as explored during the ERC StG project “CUHL”. The two main objectives of the project are i) to develop compact, graphene-based proof-of-concept thickness determination demonstrators tailored towards concrete applications, which outcompete existing technologies; and ii) to develop business cases and commercialization strategies for this thickness determination technology. These objectives will be addressed by an experienced and multidisciplinary team consisting of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Toward quantum domain new generation of experiments with laser cooled he' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The pursuit of this program is to continue the recent work on a advanced and unique setup of VSCP trapped He* atoms*) and to extend the experiment to the study of first and higher order atomic interference. Here, pushing the actual experiment towards the highest possible density of trapped atoms is the central purpose of this proposal. Within this frame the application of new technologies for trapping (dark state traps or spin-vortex traps) as well as the investigation of loss mechanisms (Penning collisions) will cover more than one year. In the second half of the program the new set-up is expected to achieve densities large enough to provide a brilliant source for a cold-atom interferometer to study atomic coherence**) or to enable Hanbury-Brown Twiss experiments***) to search for quantum statistical effects. *) VSCP-trapped: Velocity Selective Coherent Population trapped **) first order interference **) second order interference Fig. 1: atom interferometer Fig.2 Hanbury-8rown Twiss experiment (first order interference) (second order interference)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel small molecule activators of the NLRP3 inflammasome as immunostimulants' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

We have identified a novel family of potent small molecule activators of the NLRP3 inflammasome. The goal of this project is to determine the feasibility of developing these new immunostimulators into an attractive commercial proposition. Establishment of technical feasibility will involve identification the most promising modifications of our drug candidates and testing their efficacy in disease models of cancer and immunization. In addition, we will determine commercial feasibility by conducting market research and competition analysis and by engaging potential industry partners.


**Keywords:** Immunostimulator, Cancer-immune-escape, Adjuvant, Small-molecule drug, Inflammasome, NLRP3, Interleukin-1
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DEVELOPMENT OF TWO COMPLEMENTARY SYSTEMS FOR THE STUDY OF RECOMBINATION AND PACKAGING OF HEPATITIS C VIRUS GENOMIC RNA USING FLUORESCENT PROTEINS AND LIVE IMAGING' under Seventh Framework.

assistant: **Concept**

The Hepathitis C Virus (HCV) infects more than 150 million people worldwide and is the major cause of hepatic cirrhosis and hepatocellular carcinoma. Current available treatment options have limited efficacy and result in effective viral suppression only in about 50% of treated patients. In addition, HCV exhibits an extremely high genetic variability, mainly due to lack of proofreading activity of the viral RNA polymerase and its ability to generate recombinant genomes.  Genetic diversity allows the virus to evolve variants capable to escape immune response and drug pressure and hampers the development of effective vaccines. Research of novel specific drugs is hindered by our limited understanding of several key steps of the viral life cycle.To clarify different aspects of HCV RNA biology, we propose the development of two new assays based on detection of fluorescent proteins. Our first objective is to use the reconstitution of a GFP protein to measure native recombination capability of HCV under different infection conditions. This part will clarify the relative importance of several factors in the generation on new recombinant forms. Subsequently, we will deploy a system to visualize genomic RNA and viral Core protein simultaneously in live cells. By fusing different fluorophores to RNA-binding proteins and to the Core, we will be able to measure packaging and copackaging efficiencies of HCV. Lastly, we will trace the pathway of RNA molecules and Core using live imaging. This will help identifying the sites of recombination, dimerization and packaging in the cell.Taken together, the data produced will help clarify several important aspects of the viral replication cycle, and identify possible new targets for antiviral intervention. Moreover, the systems proposed repre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'IDEOLOGICAL IMPLICATIONS OF INTERCULTURAL TRANSLATION' (IDEO-TRANS).

assistant: **Concept**

The objective of the project consists in continuing individual research in the field of translatology (including ideological, cultural and linguistic aspects) as well as in enhancing didactic, linguistic and methodological competence.The project is to be implemented in two academic units: University of Veracruz in Xalapa (Mexico) and Adam Mickiewicz University in Poznan (Poland).Objectives, actions and results:1.Development of intercultural translation research and propagation of relevant authored theses:•preparation of the didactic theme of “Intercultural translation” course•analysis of a corpus that is difficult to access in Poland;•Mexican editorial market research and research corpus expansion;•research on reception of translation among UV students;•organisation of discussion panels for Phd Studies in Linguistics at UV – Phd research themes;•individual publications;•participation in thematic congresses.2.Development and improvement of my own competence as a lecturer and a specialist teaching Audiovisual Translation, Translation Cultural Conditioning, Translation&Communication and the 20th Century Translation Theory classes as a part of Phd studies in Linguistics at UV:•expansion of the corpus with audio/video publications and books available in Mexico;•participation in academic consultations for Phd students;3. Enhancing the knowledge of Latin American Literature research methodology.4. Intensive Nahuatl language course.5. Development of bilateral UAM-UV cooperation:•series of thematic lectures at UAM;•translation and literature projects for UAM students.6. Web design and web administration course, website preparation.7. Promotion of international and interacademic cooperation, propagation of translatology and polyglossia among specialists and a wide range of recipi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Deciphering the domestication and speciation of horses through next-generation paleogenomics using Pleistocene specimens, modern breeds and the domesticated donkey""'.

assistant: **Objectives**

Horses have played a critical role in human societies, warfare and facilitating the exploration of novel territories. Moreover, the rich fossil record of the horse family is one of the most widely known examples of macroevolutionary change. Hence, horses offer a unique paradigm to understand the processes of domestication, lineage divergence and speciation. However, horses have become almost extinct in the wild precluding direct comparison of domestic and wild horse genomes. Here, we aim at using state-of-the-art ancient DNA methods in combination with 2nd and 3rd generation sequencing technologies to characterize the complete genomes of two Pleistocene horses conserved in permafrost soils, dating back to 13 KYBP and 700 KYBP respectively, together with the genomes of 4 modern domesticated breeds, the Przewalski horse and the domesticated donkey. The 13 KY-old genome will deliver the sequence of all horse genes before humans started breed selection and comparative genomics against modern breeds will reveal the genetic changes that occurred in the course of the domestication process. The 700 KY-old genome will illustrate genetic changes that occurred at deeper periods of horse evolutionary history. In addition, this multidisciplinary project will provide insights into the mysterious evolutionary history of the highly endangered Przewalski horse. Significantly, characterizing the complete genome of a 700KY-old individual will crack the time line for ancient DNA preservation by at least one order of magnitude. This will be achieved thanks to major methodological breakthrough as explored in this proposal, including ancient DNA repair and true Single Molecule Sequencing. As such, the EquusPaleoGenomics project will pave the way for the next-generation of paleogenomes by open
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'SpatioTemporal Reconstruction of Interacting People for pErceiving Systems'.

assistant: **Concept**

People constantly interact with objects to perform tasks. To help people accomplish these, computers need to perceive Human-Object Interactions (HOI), and for this, they need to reconstruct HOI from whole-body color images of people interacting with objects or scenes. This is challenging, due to the occlusions between bodies and objects, motion blur, depth ambiguities, and the low image resolution of hands and graspable object parts. There has been significant prior work on estimating 3D humans without considering objects, and estimating 3D objects without considering humans. Little prior work estimates these jointly, but, for tractability, focuses either on interacting hands, ignoring the body, or on interacting bodies, ignoring hands. Only recent work addresses dexterous interaction of whole bodies, but instruments bodies with intrusive markers or sensors, and uses non-standard cameras to capture video of interactions. Moreover, reconstruction lacks hand detail that is crucial for grasping, and videos are captured in constrained settings, consequently, methods trained on these struggle generalizing. My goal is to infer HOI from natural whole-body images/videos. To this end, I present an ambitious 5-year research agenda with novelties in four directions: (1) developing strong generative 3D shape models for objects and humans for a novel HOI representation; (2) developing methods that estimate 3D HOI from a color image with rich contact and proximal awareness; (3) instilling spatiotemporal reasoning into the heart of these for estimating 4D HOI from color video; and (4) extending these methods to also infer their own confidence that will be correlated with the reconstruction quality. The outcome will be novel and robust methods for HOI reconstruction from natural images
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Next generation short-sea ship dual-fuel engine and propulsion retrofit technologies'.

assistant: **Concept**

The SeaTech consortium is proposing to develop two symbiotic ship engine and propulsion innovations, that when combined, lead to an increase of 30% in fuel efficiency and radical emission reductions of 99% for NOx, 99% for SOx, 46% for CO2 and 94% for particulate matter. The innovations will be characterized by high retrofitability, maintainability and offer ship owners a return-on-investment of 400% due to fuel and operational cost savings. The proposed renewable-energy-based propulsion innovation is the bio-mimetic dynamic wing mounted at the ship bow to augment ship propulsion in moderate and higher sea states, capturing wave energy, producing extra thrust and damping ship motions.The proposed power generation innovation is based on the idea of achieving ultra-high energy conversion efficiency by precisely controlling the auto-ignition of the fuel mixture at every operating point of the engine for achieving radically reduced emissions. The ultimate objective of the project is to upscale both technologies, demonstrate them in relevant environment and finally model the expected complementarities and synergy effects of deploying both innovations on a short-sea vessel scenario by extrapolating demonstration data with the help of a bespoke Advanced Data Analytics Framework.The project partners envisage to commercialize both symbiotic innovations in the European and Asian short-sea market by 2025, followed by the adjacent deep-sea market. Assuming only 10% of EU short-sea vessels would be retrofitted with SeaTech, this would result in CO2 savings of 32.5 million tons annually, which equals the emissions of 200.000 passenger cars/year. Further impact includes savings of EUR 85.2 billion in health and climate change damages due to lower emissions, the creation of +100 jobs a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Fostering the adoption of GALILEO for Mobility as a Service' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

GALILEO 4 Mobility aims at supporting the introduction of GALILEO technology within the Mobility as a Service context, by analysing the needs in terms of geolocation of the different stakeholders involved and demonstrating the benefits of GALILEO through pilot demonstrators of shared mobility services.Urban mobility is becoming an issue of great importance in today’s society due to the increasing population movements towards big cities and the exponential growth of cities in developing countries. Today, urban mobility schemes are evolving faster than ever mainly due to social, economic and technological changes. The democratization of smart mobile devices is allowing new business models based on sharing goods and services: the sharing economy. Its fast growth during recent years reflects a shift from owning goods toward accessing them when you need them. In that context, shared mobility services have grown exponentially during last years, with the potential to become an integrated system of multi-modal mobility services: the so-called “Mobility as a Service” (MaaS).Geolocation of users and vehicles by means of satellite navigation technologies has been widely used and it´s a key enabler for most of the services. While traditional GPS-based solutions have proven not to be a reliable solution, GALILEO will further improve signal availability, thus enhancing continuity of service for shared mobility services in urban or challenging environments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Connectivity, plasticity and function of an olfactory memory circuit' (MCircuits).

assistant: **Innovation**

The brain accumulates knowledge by experience-driven modifications of neuronal connectivity and creates models of the world that enable intelligent behavior. It is thought that these processes are based on autoassociative mechanisms of circuit plasticity. However, direct tests of these fundamental concepts are difficult because they require dense reconstructions of neuronal wiring diagrams. We will dissect structural and functional mechanisms of autoassociative memory in telencephalic area Dp of adult zebrafish, the homologue of olfactory cortex. The small size of the zebrafish brain provides essential advantages for exhaustive measurements of neuronal activity and connectivity patterns. Key predictions of theoretical models will be examined by analyzing effects of odor discrimination learning on the dynamics and stability of odor representations in Dp. The underlying structural circuit modifications will be examined in the same brains by circuit reconstruction using serial block face scanning electron microscopy (SBEM). The dense reconstruction of neuronal ensembles responding to learned and novel odors will allow for advanced analyses of structure-function relationships that have not been possible so far. Odor stimulation in a virtual environment will be combined with optogenetic activation or silencing of neuromodulatory inputs to write and disrupt specific olfactory memories and to analyze the effects on behavior and connectivity. The underlying cellular mechanisms of synaptic plasticity and metaplasticity will be examined by electrophysiology, imaging and optogenetic approaches. Mutants will be used to assess effects of disease-related mutations on circuit structure, function and plasticity. These mechanistic analyses are guided by theoretical models, expected to g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Drug loading of implant surfaces with local controlled release system' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

This proposal deals with the development of a technology for drug loading and a controlled release system on the surface of a metal implant. Five promising coating technologies will be examined in order to develop this loading and releasing technology. The research will be done on a generic surface and finally result in the development of a prototype implant. In Drugloresys a complex implant surface was chosen for this purpose, namely a stent to be placed in the vessel of a patient whose vessels are narrowed due to plaque. Vascular diseases are in 40% the cause of death in the EU, as the narrowing of vessels (restenosis) lead to heart attacks as well as strokes. A promising method to reduce the amount of restenosis would be a drug-coated stent, releasing drugs locally. The impact of a solution for local drug delivery in vascular diseases is high, but also the future application areas are most promising, such as oncology and diabetes as well as orthopedic surgery.