RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Saracatinib Trial tO Prevent FOP' under Horizon 2020.

assistant: **Concept**

Fibrodysplasia ossificans progressiva (FOP) is a rare, disabling and life-shortening congenital syndrome for which no effective therapies exist. Repurposing of AZD0530 (saracatinib, AstraZeneca) would be an ideal solution for de-risking early clinical studies. Using existing assets and investments, this may allow more affordable pricing once an indication is approved. Ectopic bone is formed in soft tissues due to activating mutations in the bone morphogenetic protein receptor kinase ALK2/ACVR1, leading to progressive contractures and early death. Preclinical studies showed AZD0530, previously unexplored in FOP, to be a potent (5nM) inhibitor of ALK2 kinase and ALK2-R206H-mediated neofunction after activin stimulation. In mice, AZD0530 blocked ectopic bone formation preserving limb movement.Hypothesis: AZD0530 will reduce ectopic bone formation and progressive disability in people with FOP.AIM: to provide proof of concept that AZD0530 is an effective drug in the treatment of patients with FOP.Methods: Based on the rarity of the disease and expected drug efficacy (50% reduction in new bone), a phase 2A proof of concept study including a 6 month randomized placebo controlled study and 12 month open label extension study using historical data, is proposed including 16 adults with active FOP disease. The study will be performed in three European FOP expert Centers (Amsterdam The Netherlands – Lead, London UK, and Garmen Partenkirchen Germany). The study will be performed in collaboration with the expert preclinical teams at the Universities of Oxford and Harvard. FOP expert and patient engagement as well as safety will be ensured by establishing advisory, DSM and stakeholder boards. Early involvement of the regulatory agencies are planned.Expectations: we will develop a road
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Efficient Environmental-Friendly Electro-Ceramics Coating Technology and Synthesis' in the context of a Seventh Framework call.

assistant: **Objectives**

Ceramic functional layered coatings are strongly required for innovations in communication, electronic and energy technology and in catalysis. The potential of these ceramic coating materials is based on their manifold special material properties.  This project proposes an alternative synthesis of the layers based on the chemical solution deposition (CSD) process at ambient pressure. Main advantages are the lower investment, the faster deposition with higher yield and the processing under ambient pressure enabling a complete continuous processing.   The general scopes of this project will be: - to introduce flexible and cost effective production systems - to implement innovative synthesis pathways and soft chemistry to avoid excessive energy input and to produce the materials in semi-custom device manufacturing - to shorten the number of reaction steps by using ‘clever pathways’ during technological processing - To enable an environmentally friendly process by promoting water as the preferred medium and avoid the release of toxic gases  These goals will be implemented in the process steps : - chemical formulation: avoid hazardous precursors by promoting water as the preferred precursor - CSD coating deposition: qualification of innovative deposition techniques based on modified ink-jet printing (electro-magnetic assisted and solution plasma spray assisted  - Processing: using ‘in situ’ modifications as electromagnetic or thermal activation to realise a more efficient process - Transfer: Optimised scaling up in view of specific industrial applications based on the protocols optimised in previous sections. - ‘in-situ and ex-situ’ characterisation.  To reach these challenging goals the consortium consists of research institutes with complementary expertise in synthesis and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The innovation journey of tourism entrepreneurs: evidence from the UK and Spain and policy implications' (INNOVATE).

assistant: **Concept**

This study seeks to bridge the conceptualization of innovation and entrepreneurship, analyse the entrepreneurial practices leading to tourism innovation in two different countries, and contribute to the design of more effective policies to enhance innovation practices across the EU. Specifically the study will address three main objectives which will be achieved using a mixed method research, involving both qualitative and quantitative approaches. First, to understand the innovation journey initiated by entrepreneurs in tourism, analysing the process and how these differ in the contrasting economic, tourism and institutional environments of Spain and the UK. This involves mainly a qualitative approach and the narratives of innovative entrepreneurs will be gathered through in-depth semi-structure interviews. Secondary data analysis and a first period of secondments with policy partners dealing with tourism and innovation will contribute to set the specific contexts influencing the innovation process in each country. Second, to analyse the development and performance patterns of a sample of young innovative entrepreneurs in tourism through a longitudinal study in Spain, specifically focussing on the determinants of innovation success or failure. Building on an initial previous contact, this will be accomplished through follow up interviews. And third, to inform policy guidelines and business practices through co-production of applied knowledge and guidelines with entrepreneurs and policy partner organizations in the UK and Spain. Key policy aspects identified during the previous stage will be transformed in collaboration with the policy partner organisations in an online survey targeting entrepreneurs to create validated policy guidelines. In summary, this contribution wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'TESTING THE EFFECTIVENESS OF AID ALLOCATION USING EXPERIMENTAL ECONOMICS' (TAAWE).

assistant: **Innovation**

Official Development Assistance (ODA) represents the major flow of resources from rich to poor countries. In 2005, $107 billion of ODA were disbursed by the Development Assistance Committee (DAC) to less developed countries. Of these, $56 billion were provided by EU members. According to the literature, despite substantial amounts of aid that low income countries have received in the past decades, the expectation that aid boosts investment and growth in recipients has not been met. The limited effectiveness of aid to reach the intended objectives has encouraged greater attention on whether current practices in aid implementation and allocation processes are appropriate, given imperfections that characterize markets in poor countries. More recent academic theory, primarily developed in European academia, has shown that donors are not able to design appropriate aid contracts: recipients do not perceive sufficient incentives to make aid effective. The aim of this research is twofold: first, theoretically, to design “incentive compatible” contracts between donors and recipients and explore in detail whether the screening process undertaken by donors can be improved. Second, given the poor quality of data for developing countries, the objective will be to test the assumptions and evaluate the policy implications of the theoretical model, by means of appropriate economic experiments. The Marie Curie fellowship will offer a unique opportunity to reach the above objectives, by allowing Dr. Isopi, whose research activity has focused primarily on contract theory applications to foreign aid, to spend time at the Nottingham School of Economics and benefit from the research expertise in two of the most highly regarded Development and Experimental Economics research centres in Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Leap in Advancing of crItical Quantum key distribution-spAce components'.

assistant: **Objectives**

LaiQa comes as a technology intensive research and innovation action aiming to develop and advance critical components and technologies necessary to build a global spaced-based quantum network. LaiQa envisions to realize unconditionally secure quantum communications over long distances bringing functional QKD components together with advanced system integration techniques towards deployable space-QKD systems. The project's objectives will include the development of space-deployable, high-brightness 1550 nm entangled photon pair source (EPPS), a space-suitable Decoy State - BB84 Prepare and Measure (P&M) source, a photonic integrated EPPS for next-generation on-board sender stations, a quantum memory for long-distance entanglement distribution, an advanced fiber-coupling/adaptive optics system for converged space/terrestrial QKD segments, and software components towards the optimization of LaiQa architecture. The project will demonstrate P&M- and entanglement based QKD systems both in lab/terrestrial FSO testbeds and in field demonstrations in Helmos optical ground station (OGS). LaiQa will also mobilize its consortium to prioritize standardization activities that focus on space components for P&M- and entanglement-QKD, consider interfaces and parameters for them to propose specification standards and potentially trigger new standardization activities within EU.


**Keywords:** prepare and measure QKD, entanglement based QKD, quantum memory, PIC, fiber coupling, optical ground station, space qualified quantum sources, secure key rate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Resistance genes to salmonella carrier-state in fowls' to be submitted under Fourth Framework.

assistant: **Abstract**

Salmonellosis is one of the major cause of human disease related to food consumption. Poultry products are the main source of human toxi-infections, mostly because of asymptomatic carrier-state (i.e persistence of Salmonella in apparently healthy fowls several weeks after contamination or experimental inoculation). Most often the serotype responsible for human food poisoning is Salmonella enteritidis. Caecal and ovarian Salmonella carrierstate will be considered. The former results in horizontal transmission of the bacteria and leads to human disease through contamination of the egg shell at the oviposition and of the carcass during evisceration. The latter results in vertical transmission of Salmonella and in yolk contamination. It has been shown that resistance to Salmonella infection and carrier-state was partly genetically controlled. Major genes of resistance to infection have been identified whereas genes controlling resistance to carrier-state are still unknown. Our objectives are therefore: 1. To discover which genes control caecal carrier-state after inoculation with Salmonella enteritidis, 2. To find out to what extent these genes also control resistance to ovarian carrier state after inoculation with Salmonella enteritidis, 3. To study the mode of action of these genes to help in their identification and their use for selection. In the longer term (beyond the limits of this project) these results will be transferred (by comparative genetics) to other animal species also susceptible to Salmonella but which lend themselves less favourably to genetics studies. We shall first measure in a commercial poultry line the effects of the resistance genes already identified in mouse (TASK 1) or mapped in fowls when studying resistance to mortality (TASK 2). As genes cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Targeting the biological imaging market with multifunctional fluorescent nanoparticles'.

assistant: **Innovation**

BioNLight has been designed to investigate the prospective of commercially exploiting our multimodal nanoparticle technology in the biological imaging market. The introduction of this technology will open up an entirely-new window of molecular imaging possibilities, thereby supporting advances in biology, drug discovery & development and diagnostics.Funded by ERC, Prof. Brunsveld and colleagues have developed modular nanoparticles that exactly address the needs of the molecular imaging field. These nanoparticles of organic nature can be produced in a reproducible one-step method by self-assembly in water. The result is a highly-robust and biocompatible nanoparticle that can be modulated to emit any desirable colour frequency with long-term emission and high photostability. Moreover, they can be functionalised with multiple ligands thanks to great control over surface functionality and can be prepared not only for fluorescent studies, but also for other imaging technologies. In practise this implies that the technology platform can be used to advance a wide range of in-vitro and in-vivo assays and to visualise yet-uncovered processes.It is the objective of BioNLight to select the most interesting applications for commercialisation and to build up a prospectus that can be used to convince future customers of the practicability and the imaging power of our technology platform. Besides, we aim to construct a sound business model and strategy for commercialisation. This will be done by external validation of the nanoparticles by industry followed by final optimisation, by means of an extensive market study, by building a strong IP position and by setting up a business plan with detailed financial feasibility projections. The ERC Proof of Concept Grant will enable us to take
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unraveling novel Familial Breast Cancer (FBC) predisposition genes.' under Horizon 2020.

assistant: **Concept**

Breast cancer is the most common cancer in women worldwide. Familial breast cancer (FBC) is expected to account for up to 15% of breast cancers. Although recent breakthroughs have resulted in the identification of distinct new groups of genetically inherent breast cancer genes, about 64% of the genetic predisposition to FBC remains unexplained. Therefore, new approaches are required to identify remaining genetic factors underlying FBC susceptibility. This is crucial because the elucidation of inherent cancer defects offers the ability to counsel and monitor patients. Importantly, it also provides firm ground for therapeutically targeting particular cancer pathways for example through Poly ADP-ribose polymerase inhibitors (PARPi) that exploit synthetic lethality with particular DNA repair deficiencies. To advance the field, my host lab has performed High-Throughput phenotypic screen, based on gene variants recognized in a FBC cohort of 135 early-onset (age <35 years) breast cancer patients through whole exome sequencing. The 270 new genes with potential disease association were enrolled in screens, focusing on genome maintenance and PARPi sensitivity. These unique preliminary data form the basis for my project. I hypothesize that by performing following specific analyses I will be able to elucidate new FBC predisposition genes:•Ranking of screen hits by performing FBC-associated variant analysis in an international and Danish FBC cohort.•Elucidating molecular function of novel FBC predisposition genes in genome maintenance.  •Unraveling the molecular network of candidate proteins by unbiased Mass-spectrometry as well as follow-up analysis of interactors.  I anticipate that my work will provide novel FBC predisposition genes, which will markedly contribute to clinical ris
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Pioneering vegan whole cuts through mycelium solid state fermentation'.

assistant: **Objectives**

Esencia Foods is the first company in Europe to exploit the unique properties of mycelium combined with the advantages of an enhanced solid-state fermentation for whole cuts of any kind, starting with fish and seafood.We stand as the pioneering company in Europe, employing solid state fermentation with mycelium to achieve natural textures with minimal processing, two ingredients and a lower price point than animal-based counterparts.Solid state fermentation utilising tray bioreactors allows novel texturizing technologies to mimic the texture of whole cuts when exploiting the natural fibrous texture of mycelial fibres and mycelium’s gelation properties. This is a key step for re-producing complex textures; it also significantly reduces the need for expensive additives and intensive post-processing for texturization. By harnessing solid-state fermentation, we can cultivate mycelium (filamentous fungi) in controlled conditions that surpass natural growth and do so quickly and on a scalable level. Additionally, this process can be carried out locally, close to where (otherwise unused) side streams arise, and it requires minimal water compared to Liquid State Fermentation (most used technology today for the production of mycelium-based alternative products)We anticipate operating within a serviceable obtainable market (SOM) of approximately €5.3 billion by 2028. We project that we can realistically capture approximately €18 million of this market share by 2029. We have received LOIs from 9 restaurants based in Barcelona, Spain, 1 Canteen and 1 business caterer in Germany, 2 Catering companies based in Barcelona, Spain, 2 Chefs based in Germany and Spain, 4 Food Producers from Germany and The Netherlands, and 3 Food retailers/Grocers from Switzerland, The Netherlands and Germ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Structural Openings to Understand and Prevent Tick Borne Encephalitis', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Tick-borne encephalitis virus (TBEV) is emerging in Europe. It causes tick-borne encephalitis (TBE), a disease with a high mortality rate and even higher rates of life-long neurological effects in individuals that contract infections. As environmental and societal changes promote viral spread and current vaccine use is limited, it is not surprising that TBE incidence is on the rise. With uncertain diagnostics and no medications on the market, the threat to European health care becomes significant, making development of control measures a high priority. Efforts to develop treatments and improve detection are largely hampered by a lack of structural knowledge about TBEV. Here we seek to fill the critical information gap, using electron cryo-microscopy, which has become a powerful technology for revealing atomic-level details about viruses. We will harness unique expertise in the fields of virology and structural biology to answer fundamental questions about virus structure, assembly, morphogenesis, and function. Explicit new knowledge regarding TBEV will push forward European excellence in virus research producing impactful results for their exploitation in drug discovery and diagnostic developments.