RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Cellular and molecular regulators of the pleiotropic activities of gamma delta T cells in the tumor microenvironment'.

assistant: **Objectives**

Immune cells constitute a major component of the tumor microenvironment (TME) that influence several aspects of cancer progression and outcome. The host laboratory has identified two distinct γδ T-cell subsets with opposing roles in tumor progression: whereas interferon-γ (IFN-γ)-producing γδ T-cells stimulate anti-tumor responses, IL-17A-secreting γδ T-cells promote angiogenesis and tumor growth. However, the cellular and molecular factors controlling the critical balance between these antagonistic subsets remain unknown. The present proposal builds on subsequent relevant findings of the host laboratory, namely that neutrophils suppress IL-17A+ γδ T-cell proliferation, revealing an unanticipated neutrophil/γδ T-cell crosstalk in TME, and that on another side the metabolic resources may also play a critical role in γδ T-cell subsets.Based on these foundations, within the present proposal we will:a) identify TME cellular partners that determine the balance between IFN-γ+ and IL-17A+ γδ T-cells in several experimental models of cancer. b) study the metabolic pathways employed by γδ T-cell subsets and the impact of manipulating those pathways on their balance within the TMEc) analyze the impact of immune crosstalk and metabolic resources on γδ T-cell subsets both at transcriptomic and epigenetic levels. Overall, this project will provide conceptual advances that will foster innovative strategies to promote anti-tumor γδ cell functions at the expense of their pro-tumoral activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Quantum Information Theory with Liouvillians' to be submitted under Seventh Framework.

assistant: **Abstract**

The project's main goal is composed of a scientific and an academic training component, and it is to be implemented in the Department of Mathematics at the Technical University of Munich in the research group of Prof. Michael Wolf.The first scientific aim is to extend the mathematical framework underlying the ''dissipative paradigm'' of quantum computing, placing special emphasis on continuous-time evolutions that may be controllable to a certain extent and may include non-Markovian elements. Providing such a rigorous toolbox and extending vital theorems from the Hamiltonian case to the dissipative paradigm forms the first two scientific objectives. Two further objectives use these tools to achieve the project's aim to incorporate controllable dissipative evolution into central parts of Quantum Information Theory. Namely, we aim to establish a Quantum-Shannon-Theory for the controllable time-continuous case - relevant for quantum memories - and explore its basic features. Further, we aim to investigate the computational complexity of dissipative state preparation in quantum many-body systems, contrasting it to Hamiltonian Complexity. These objectives will be achieved mainly through analytic work, also employing computer simulations.Beyond research, the academic training component aims to prepare the fellow for a future career as an independent researcher. As specific objectives to achieve this, the fellow will mentor students and (co-)supervise research projects jointly with Prof. Wolf during the fellowship. Further, the fellow will (co-)teach a specialized lecture course and a seminar. Through active involvment in the research group and grants, the fellow aims to acquire essential leadership and management skills.The project objectives are of high relevance to the Work
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sustainable Combined Heat Absorption Refrigeration And Power' (SCHARP).

assistant: **Innovation**

This project will research and demonstrate an innovative concept for an Energy Services Company providing local energy networks, comprising combined heat and power (CHP), absorption cooling, heat and chilled water networks and private wire to a superstore. It will provide not only CHP services for electricity, heating and air conditioning but also for refrigeration to reduce both energy consumption and greenhouse gas emissions as well as the use of refrigerants. The project will also demonstrate how such a system can act as the catalyst for a local community energy system providing energy services to both nearby businesses and local housing to achieve a complementary balance of different types of consumer loads in a move towards sustainability in energy in a fully deregulated energy market. This will establish an important economic and environmental model for the emerging deregulated energy market in the European Union.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fundamentals of Holographic Dualities via Non-relativistic Systems and Quasinormal Modes' in the context of a Horizon 2020 call.

assistant: **Objectives**

Since their advent, holographic dualities have been a major focus of theoretical physics research. These dualities are maps between field theories in d dimensions, and gravities in d+1 dimensions.  In these maps, any physical quantity in the field theory has a dual in the gravitational theory, and vice versa.  ""Dual"" means that a calculation in the field theory will always give the same answer as a calculation in the gravitational theory (and vice versa). These dualities thus provide powerful access to new physical descriptions. They have been applied far beyond their original high-energy theoretical physics regimes, to subjects ranging from superconductors to heavy-ion collisions.  This project will study the underpinnings of holographic dualities for applications to non-relativistic systems like superconductors. In order to put these conjectured applications on stronger footing, this project will also examine the role played by ""quasinormal modes"" in dualities.  During her graduate work at UC Berkeley, and her postdoctoral positions at Harvard and University of Michigan, the proposed fellow has acquired ample research experience in the areas covered in this proposal, and will be able to expand on collaborations with some of the world experts in the field.  The proposed host institution, the Niels Bohr Institute (NBI), provides an ideal fertile environment for developing research at the forefront of physical understanding, and particularly so for this project due to local expertise among its faculty, postdocs, students, and thriving international visitor program.  During this project, the fellow will acquire further skill in the cross-disciplinary areas of the proposal, including condensed matter physics as well as mathematics. The host, fellow, and the EU as a who
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Thresholds of Environmental Sustainability' in the context of a Sixth Framework call.

assistant: **Objectives**

THRESHOLDS seeks to contribute to the development of Sustainability Science and through the implementation of a procedure for policy formulation based on the development of a target setting process that integrates scientific knowledge on thresholds of indicators of environmental sustainability, the socio-economic activities that impinge in these indicators and the components of their vulnerability, and the evaluation of the resulting externalities associated with these socioeconomic activities. THRESHOLDS carries out innovative crosscutting research to develop, improve and integrate tools and methods to provide the basis to formulate sustainable strategies through research to deliver the scientific tools to identify Thresholds and Points of No-return of Environmental Sustainability and externality valuations required to define targets for the development of the European Sustainable Development Strategy. The THRESHOLDS IP will confront complex behaviour of ecosystems, such as regime shifts between alternative stable states, and complexity in valuation of the sectors affecting environmental quality, such as non-linear cost-pressure relationships and multi-sectorial situations to develop procedures that accommodate to the complexity of the socio-economic and environmental systems. The tools developed will be applied to case studies in the European coastal zone, where policy needs are pressing, involving increasing levels of complexity, from local to pan-European. THRESHOLDS IP will draw on the extensive data sets and research results produced on the basis of national efforts as well as previous framework programmes, which have focussed on major environmental problems and have delivered models and data which can be used to define Thresholds and Points of No Return. The THRE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Business Process Re-engineering and functional toolkit for GDPR compliance' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The goal of BPR4GDPR is to provide a holistic framework able to support end-to-end GDPR-compliant intra- and inter-organisational ICT-enabled processes at various scales, while also being generic enough, fulfilling operational requirements covering diverse application domains. To this end, proposed solutions will have a strong semantic foundation and cover the full process lifecycle addressing major challenges and priorities posed by the regulation, including requirements interpretation, broad territorial scope, accountability, security means enforcement, data subject’s rights and consent, unified data view and processing actions inventory, privacy by design, etc.The starting point will be process models, either automatically discovered through organisation logs or manually specified, formally expressed through a Compliance Metamodel, a comprehensive process modelling technology able to capture advanced privacy provisions. Thereupon, a highly expressive policy framework will guide the automatic verification of these models regarding GDPR requirements, and their subsequent transformation, so that they are rendered inherently privacy-aware before being deployed for execution. Subsequently, the consistent execution of GDPR-compliant processes will be ensured by a comprehensive set of tools able to support all diverging requirements that may arise from GDPR, related to data handling, data subjects’ involvement, various PETs, etc., so that even organisations with currently no such infrastructure in place can readily have such mechanisms. Finally, process mining will be extensively used for the ex post analysis of processes, in order to ensure that specified policies are indeed enforced. However, apart from verifying compliance, such techniques will offer the added value of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Discovering Collagen I degradation process in chronic diseases with fibrotic component'.

assistant: **Objectives**

Fibrosis-related chronic diseases (CDs) are amongst the biggest societal burdens in Europe, with fibrosis being recognised as the main driver of morbidity and mortality. Extracellular matrix (ECM) is a key player in fibrosis, with an excessive accumulation of type I collagen (COL1) being a predominant component of the fibrotic tissue. While the increase in COL1 production is considered a main driver of fibrosis, respective drugs had limited efficacy. New evidence indicates that attenuation of COL1 degradation is highly relevant, contributing to onset and progression of fibrosis. Ambitious early stage researchers (ESRs) will join forces within a multi-disciplinary, comprehensive and inter-sectoral doctorate training programme, embedded in an existing network of excellent research groups across Europe, to investigate the “outside-the-box idea” on impaired COL1 degradation being a key driver of fibrosis. The main scientific goal is to improve the understanding of molecular mechanisms associated with COL1 degradation in major fibrosis-related CDs, and investigate the disruptive hypothesis of attenuated COL1 degradation being the key driver of fibrosis and a major contributor to onset and progression of CDs. This will be achieved through multi-disciplinary research and training combining state-of-the-art –omics approaches and data (peptidomics, proteomics and transcriptomics) in a bioinformatics framework, followed by in- and ex-vivo investigation, complemented with ESRs training on translational skills and competences. Such a programme will train a new generation of translational researchers able to covert ideas into products, and will have a profound impact on their employability, and competitiveness. The project will progress beyond the state of the art and provide the cu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Logic of Conceivability: Modelling Rational Imagination with Non-Normal Modal Logics', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

“The human imagination remains one of the last uncharted territories of the mind”  - Ruth Byrne, The Rational ImaginationOur mind represents non-actual scenarios to extract information from them. We cannot experience beforehand which situations are or will be actual. So we explore them in our imagination, leaving our perceptions offline: ‘What would happen if...?’. The cognitive importance of this activity is hardly overestimated.But what is its *logic*? The orthodox logical treatment of representational mental states comes from modal logic’s possible worlds semantics: the modal analysis of knowledge, belief, information, was taken up by philosophy, linguistics, and Artificial Intelligence. However, the approach faces major problems. By systematically addressing them, the Logic of Conceivability (LoC) project will yield a paradigm shift in our understanding of the logic of human imagination.One major purely logical problem is that mainstream epistemic logics model cognitive agents as logically omniscient, thus as disconnected from the reality of human, fallible minds. One major philosophical problem concerns the entailment from conceivability to so-called absolute possibility in ‘thought experiments’ of theoretical philosophy: how does conceiving a scenario give evidence of its possibility? LoC will address such issues via the techniques of non-classical logics with non-normal worlds semantics. It will make logically precise the distinction, taken from cognitive science, between Fast Thinking (associative, context-sensitive) and Slow Thinking (rule-based, analytic). It will show how omniscience is avoided, and evidence of absolute possibility is achieved, in different manners in the Fast and Slow Way.Based at the Institute for Logic, Language and Computation, and advise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Clinical performance validation of a novel biomarker for quantitative imaging of coronary artery disease.' (MPIPETrace), addressing dissemination and exploitation.

assistant: **Impact**

Coronary Artery Disease (CAD) is the most common form of heart disease and is the leading cause of death in Europe andthe Western World. Positron Emission Tomography (PET) Myocardial Perfusion Imaging (MPI) offers the unique possibilityof measuring and quantifying myocardial blood flow and coronary flow reserve in absolute terms, which serve as aprognostic marker for adverse cardiac events: It can predict the risk of heart attack. PET also offers advantages such as:superior image quality and diagnostic ability, reduction of unnecessary invasive downstream procedures and reduction ofpatients’ risks due to reduced radiation doses and shorter period of radiation retention. Currently, there is a shortage ofavailable, simple and efficient PET myocardial perfusion imaging agents. Motivated by the growing business opportunity inPET cardiac imaging and the success of completed synthesis and evaluation discovery process, as well as pre-clinical trialsand toxicity tests, the objective of this project is Phase 1 and 2 clinical trials of the novel biomarker [11C]-DMDPA forMyocardial Perfusion Imaging using Positron Emission Tomography, and to commercialize it globally. The adoption ofPositron Emission Tomography for Myocardial Perfusion Imaging will occur as a result of numerous advantages and thegrowing abundance and availability of PET scanners in recent and future years. There is compelling evidence that our novelbiomarker is addressing a high growth trend in a high volume market of the cardiovascular disease nuclear imaging, andspecifically the growing need of non-invasive PET cardiac probes. According to publications, the projected growth ratesindicate that PET will outnumber SPECT cardiac procedures by 2020. The willingness to pay has been confirmed during oureconomic feasibi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Improving Pregnancy Outcomes Gloablly'.

assistant: **Objectives**

Preeclampsia is responsible for the deaths of more than 70,000 mothers and half a million babies each year. Identifying those mothers at risk of preeclampsia is difficult. The current gold standard in prenatal care does not detect the disease early enough to change the course of the disease. MDx has developed PrePsia™, a simple blood test which identifies an expectant mother’s risk of preterm preeclampsia, up to 5 months before most women will display clinical symptoms. Clinicians can now use this simple tool, to personalise pregnancy care, including the initiation of treatments in early pregnancy that can dramatically reduce the incidence of preterm preeclampsia by 62%3. In the EU, with about 5.1 million births per annum (2015 data) , treating the women identified at high risk for preterm preeclampsia by PrePsia™ has the potential to prevent over  37,000 cases of preterm preeclampsia and its associated severe outcomes, every year. The only other test in the market that screens for preterm preeclampsia, is complex and requires for specialist ultrasound scans to be taken, which are expensive, subjective and require for dedicated ultrasound equipment and operators. MDx has a portfolio of IP assets, as developed by the company over the last 5 years, that will protect PrePsia™ and also have significant commercial potential beyond just the realm of preeclampsia.MDx has team of successful serial entrepreneurs coupled with globally renewed technical expertise to deliver PrePsia™ to the market and build a long term self-sustaining European company. By year 4 MDx will have annualised revenues of €69 million and employment for 50 people while fulfilling its ambition to become a world leader in innovative pregnancy diagnostics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A New Zn-Air Battery Prototype to Overcome Cathode Degradation Through Catalyst Confinement' in the context of a Horizon 2020 call.

assistant: **Objectives**

Zinc-air rechargeable batteries are a promising alternative for sustainable energy storage, thanks to their high energy density and the use of abundant materials with low environmental impact, as well as their safe operation. However, they still have some technological limitations that prevent their current capacity from being completely satisfactory, especially because of the degradation that occurs at the cathode and corrosion of the anode, which ultimately limit both the reversibility and a long battery life. The proposed methodology allows to protect the (electro)catalytic centers. In this way, it is intended to extend its useful life, improving both its behavior in real conditions, and solving the existing problems in the electrodes. Thus, based on this technology, new electrodes will be manufactured that will later be tested in pre-industrial battery prototypes


**Keywords:** Bifunctional air catalyst, Secondary zinc-air battery, Bifunctional air electrode, Aqueous alkaline electrolyte, Optimized preindustrial cell prototype