RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Quantum Materials for Quantum Devices' (QuantuMDs) under Horizon Europe.

assistant: **Objectives**

In the past decade the study of Quantum Materials for Quantum Devices (QuantuMDs) has been recognized as an important research goal in both academia and industry. QuantuMDs are predicted to be the building blocks of next-generation modern technology. The material group most suitable for use in QuantuMDs is the group of transition metal dichalcogenides (TMDs), which exhibit exotic properties, such as superconductivity, charge order, Mott physics and topological states.My main goal is to develop new and exotic QuantuMDs from a variety of pure or intercalated TMDs; these new materials will enable the establishment of a new material platform suitable for quantum technology. I will pursue the fabrication and investigation of various highly correlated systems via multiple measurement techniques including electrical current pulse manipulation. I will adopt a unique combined approach of material synthesis control, high-end device fabrication and broad measurement techniques. My ability to perform a full experimental cycle on any system studied, from crystal growth to advanced fabrication and application, will enable me to undertake the most complex problems and produce creative routes to achieve the proposal goal.The impact of this work will be two-fold; First, the manipulation of exotic phases will open vast scientific possibilities in the exploration of nontrivial physical effects, specifically of single-material low-dimensional highly correlated condensed matter systems. Second, the ultra-low power, ultra-fast dynamics and robustness towards external unwanted perturbations of our expected QuantuMDs will create unlimited opportunities for the future of technological applications. The enticing possibilities include ultra-fast slidetronics-based devices, fault-tolerant supercon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Transport and signalling in Polarized Cells' (TRANSPOL).

assistant: **Concept**

Aberrant molecular signalling and intracellular trafficking are the molecular cause of many human diseases. TRANSPOL is an interdisciplinary initial stage training network (ITN) at the intersection of cell/molecular biology and membrane physics aimed specifically at the molecular understanding of the functional relationship between intracellular trafficking and cellular signalling and their relevance to human diseases. The importance of intracellular trafficking processes serving as an integral part of signalling has only recently received broader attention and demands further in-depth analysis. This ITN is specifically designed to bridge this gap between “conventional” signalling cascades and processes of membrane fusion, fission and intracellular trafficking. To tackle this important task we have assembled a unique multidisciplinary consortium combining top European scientists from the fields of cell biology, biochemistry, and physics as well as specialists from the private sector. The scientific objectives will concentrate on a better understanding of ligand/receptor-mediated signalling mechanism across the membrane, the lipid/protein interface in endocytosis, the signalling properties of endosomes, and deregulated trafficking and signalling pathways in disease. Three private enterprises are fully integrated in this ITN underlining its intersectorial character. The multidisciplinary research and training program comprises cell biology, protein and lipid biochemistry, biophysics, computational simulations, protein design and systems biology.  TRANSPOL has designed a structured 3-year curriculum providing the following hallmarks: 1. A joined academic and industrial training program/2. A combination of local and network wide European training/3. A training in scientific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Genetic basis of herbivore-induced physiological canalization.' (HECAN).

assistant: **Innovation**

Herbivores can interact with each other indirectly via the shared host plant, for instance via the induction of plant defenses. Indirect plant-mediated interactions strongly influence herbivore behavior and performance and shape plant-associated arthropod communities. The order of herbivore arrival is often critical for the outcome of plant-mediated interactions, yet the underlying mechanisms remain largely unknown. Diabrotica virgifera virgifera, a specialist belowground herbivore of maize, refuses to feed when a plant is already attacked aboveground by the specialist leaf feeder Spodoptera frugiperda. This host-avoidance behavior is attributed to changes in root-emitted volatiles upon leaf herbivory, in particular the increased production of a nitrophenol (“NP1”), which was not previously known to be synthesized by plants. However, D. v. virgifera suppresses the leaf-herbivory-induced production of NP1 when it arrives on the plant first, and hence, keeps on feeding. HECAN will investigate the genetic and biochemical bases of NP1 biosynthesis in maize in order to understand how the production of NP1 is suppressed by D. v. virgifera.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Do plants go further in deciding their cell fate: different target genes, different Polycomb Group mechanisms?' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The epigenetic mechanisms that control chromatin organization are known to regulate cell differentiation in both animals and plants. Nevertheless, why plants, unlike animals, so readily switch their cell fate in response to external signals is unclear. Furthermore, how plants regenerate a complete organism from a single somatic cell remains a mystery. Post-translational histone modifications contribute to the maintenance of chromatin states associated with a defined gene expression program. Among histone modifiers, the evolutionary conserved Polycomb Group (PcG) machinery has a key role in repressing the genes that are not required in a specific cell fate, thus, establishing cell identity. Unfortunately, our knowledge of this important regulatory mechanism is still incomplete, especially in plants in which only some PcG proteins are known. Thus far, plant PRC2-like complexes are relatively well studied, but the existence of plant PRC1 components has just been discovered. These components are homologs to animal PRC1 Ring finger proteins and are involved in H2A monoubiquitination. Plants impaired in PRC1 Ring finger components undergo dedifferentiation of somatic cells into embryonic cells, indicating that they play a central role in maintaining cell identity. Interestingly, the PRC1 Ring finger proteins apparently regulate only a subset of PRC2 targets; moreover, there are different plant-specific proteins that participate in the regulation of specific targets, suggesting that not all PcG targets are regulated by the same mechanism. Our main goal is to unveil the different PcG regulatory mechanisms in plants and their biological functions. Using a combination of genetic and biochemical approaches, we will purify the putative PRC1 complexes, determine the direct targets o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'TOWARDS A COMPREHENSIVE ANALYSIS OF EXTRACELLULAR SCAFFOLDING AT THE SYNAPSE'.

assistant: **Innovation**

Synaptic scaffolding molecules control the localization and the abundance of neurotransmitter receptors at the synapse, a key parameter to shape synaptic transfer function. Most characterized synaptic scaffolds are intracellular, yet a growing number of secreted proteins appear to organize the synapse from the outside of the cell. We recently demonstrated in C. elegans that an evolutionarily conserved protein secreted by motoneurons specifies the excitatory versus inhibitory identity of the postsynaptic domains at neuromuscular synapses. We propose to use this system as a genetically tractable paradigm to perform a comprehensive characterization of this unforeseen synaptic organization.Specifically, this project will pursue 4 complementary aims:1) Identify and characterize a comprehensive set of genes that organize and control the formation and maintenance of these scaffolds through a series of genetic screens based on the direct visualization of fluorescent acetylcholine and GABA receptors in living animals.2) Solve the spatial synaptic organization of these scaffolds at a nanoscale resolution using super-resolutive and correlative light and electron microscopy, and analyze their dynamic behavior in vivo by implementing Single Particle Tracking imaging in living worms.3) Decipher the role of the synaptomatrix in the organization of synaptic extracellular scaffolds and evaluate its functional contribution at the physiological and molecular levels using a candidate gene strategy and innovative imaging.4) Analyze the formation and decline of these scaffolds at the lifetime scale and evaluate the role of synaptic activity and aging in these processes by taking advantage of the possibility to follow identified synapses over the entire life of C. elegans.Using powerful genet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'From non-ideal magnetohydrodynamics to the structure and evolution of protoplanetary discs' to be submitted under Horizon 2020.

assistant: **Abstract**

Circumstellar discs are the birthplaces of planets. They form around young protostars and dissipate in a few million years. Modern submillimeter and optical telescopes such as ALMA and VLT/SPHERE are now ableto resolve thin structures in the bulk of these objects, such as rings, crescents, spirals and winds, probing the very origin of planetary systems similar to our own. Our current understanding of these discs relies on a very crude modelling of a hypothetic magneto-hydrodynamic (MHD) turbulence thought to play an essential role in the evolution and structure of these systems. However, there is now compelling theoretical and observational evidence that these discs are weakly turbulent, if not laminar, because of their low ionisation fraction and thus poor coupling to the magnetic field. This suggests that subtle MHD processes are driving the dynamics of these objects. Moreover, my recent theoretical breakthroughs demonstrate that these gaseous discs are subject to self-organisation and magneto-thermal winds. These processes play a key role for the disc as they can control its radial structure and evolution. I propose that computing global non-ideal MHD models from massively parallel numerical simulations will shed a new light on these processes, connecting the long-term evolution of these discs to the formation of large scale structures seen by ALMA and SPHERE. We expect MHDiscs to provide reliable global evolution models by coupling gas dynamics to dust and irradiation. These models will be used to predict discriminant observables of the processes I propose, setting the stage for a deeper understanding of the formation of planetary systems.


**Keywords:** Numerical technics for astrophysics, Magnetohydrodynamics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Understanding the drivers and impacts of homicides in 4 major Latin American cities.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This project will seek to better understand the drivers and effects of homicides in 4 major Latin American cities (Bogotá, Medellín, Cali and Mexico City) with of focus on the differential impacts on vulnerable groups especially women, while allowing an experienced French researcher—Emmanuel Letouzé—having acquired solid credentials in leading US universities and global forums to contribute to Europe’s standing in data-driven social science and policymaking. Building on the researcher’s rich interdisciplinary background, past and ongoing related work on conflict and crime, and deep international network and experience, the project will draw on the resources and expertise of UPF’s Faculty of Political and Social Sciences, Jorge Rodriquez, John Palmer, and Sebastian Sarasa, to yield 4 scientific papers and a synthesis monograph along with supporting tools and activities on homicide dynamics in these cities, with broader applicability to other regions. In particular, the researcher will leverage ‘Big Data’ sources such as cell-phone data from a major Spanish telecom operator—Telefónica— and Spanish Bank (BBBVA), in combination with official statistics on economic conditions and homicides and structural open urban data to shed light on 2 main research questions: (1) what are the key factors that seem to be driving homicides in these cities?  (2) How do homicides affect the daily behaviors of affected communities and groups especially women? In the medium term, this project will seek to pave for the way for a network of European regional urban laboratories dedicated to making cities safer and fairer around the world.


**Keywords:** Homicides, Big Data, impacts, drivers, Latin America
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Study of the sulphate exchanger Tat1 (SLC26A8) in spermatogenesis : analysis of its physiological role in mouse male germ cells and genetic investigation in the aetiology of human infertility'.

assistant: **Innovation**

Tat1 (SLC26A8) encodes for an anionic exchanger exclusively expressed at the plasma membrane of human adult germ cells undergoing spermatogenesis. Although so far the physiological role of this molecule is unknown, it has been shown to transport sulphate i n a chloride dependant manner and it is likely to fulfil critical functions during spermatogenesis. Indeed, Tat1 belongs to a family of transporters, which physiological importance has been clearly demonstrated by association with several human disorders ( Pendred syndrome, Dyastrophic dysplasia, Congenital chloride diarrhoea). Furthermore, Tat1 regulate the transport of sulphate that we know is essential for many biological processes (i.e growth, development). For instance, hyposulphation of the proteoglycans located in the extra-cellular matrix of the cartilage, leads to dramatic bone development defects in patients diagnosed for Dyastrophic dysplasia. In order to define the physiological function of Tat1 we propose to use an RNAi based methodology to specifically down-regulate Tat1 expression in the adult mouse testis. We will take advantage of a new expression vector designed to produce siRNA-like transcripts that can specifically initiate degradation of the endogenous mRNA to which they are homologous. We propose to generate transgenic mice with constructs producing Tat1 siRNA molecules, and therefore down-regulate Tat1 expression in the appropriated tissues (so far Tat1 has been shown to be solely expressed in the adult testis). In parallel, we will elect roporate the expression vector into adult mouse testis in order to locally inhibit Tat1 expression. Combination of these two approaches should allow characterisation of the potential spermatogenesis defects associated with the lack of Tat1 activity. Subsequent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Direct Township Elections in China: Political dynamics and governance outcomes' to be submitted under Seventh Framework.

assistant: **Abstract**

China's direct local elections have received a great deal of international attention, and have been a particular concern of the European Union. But there has been much more focus on understanding village elections than elections at the township level of government. Direct township elections are significant, however, because – unlike village elections – they involve the lowest tier of the Chinese governmental system. And they were suspended in 2006 after only eight years of experimentation. In this project we aim to understand first why township elections were permitted and then suspended, and second, their governance outcomes. The project will contribute to understanding the obstacles to bottom-up democratization in China, as well as the impacts of elections on local governance.We will conduct intensive interviews with 30 officials in central party-state institutions as well as Chinese and foreign officials responsible for establishing and implementing cooperative programmes or projects on direct local elections. We will also adopt an empirical case study approach to understanding the governance effects of direct elections, comparing five townships that have introduced elections with five townships that have not. This method will deliver new cross sectional data for analysis.The researcher, Professor Dong Lisheng (Chinese Academy of Social Sciences), has been closely involved in monitoring local elections in China and has unparalleled access to decision makers and local governments there. Together with a team of political scientists at the University of Glasgow with expertise in Chinese politics and in elections and electoral politics, he will be able to produce the definitive analysis of China's township level reform experience, assess the way forward for Chinese local
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Real-time Spiking Networks for Robot Control' to be submitted under Fifth Framework.

assistant: **Abstract**

Robots are of increasing importance and will become an integral part of European society. Despite continuing advances, current robots cannot approach the abilities of even the simplest mammals. Achieving continuous and real-time learning without interference between learnt tasks remains a difficult problem. To attain the learning ability and finesse of movement that animals display, information from a large number of sensorimotor and cognitive signals must be integrated. However, few principles of integration have been proposed. Our inter-disciplinary consortium of physicists, neuroscientists and engineers will investigate the principles of integration and representation in the brain. Real-time spiking neural networks, based in part on the cerebellum, a major site of sensorimotor integration and motor learning in the brain, will be developed. Both hardware and software approaches will be employed. The control abilities of these spiking networks will be evaluated with robots in real environments and compared with state-of-the-art robotic control. Robots are of increasing importance and will become an integral part of European society. Despite continuing advances, current robots cannot approach the abilities of even the simplest mammals. Achieving continuous and real-time learning without interference between learnt tasks remains a difficult problem. To attain the learning ability and finesse of movement that animals display, information from a large number of sensorimotor and cognitive signals must be integrated. However, few principles of integration have been proposed. Our inter-disciplinary consortium of physicists, neuroscientists and engineers will investigate the principles of integration and representation in the brain. Real-time spiking neural networks, based in