RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Analysis of quantum many-body systems' in the context of a Horizon 2020 call.

assistant: **Objectives**

The main focus of this project is the mathematical analysis of many-body quantum systems, in particular, interacting quantum gases at low temperature. The recent experimental advances in studying ultra-cold atomic gases have led to renewed interest in these systems. They display a rich variety of quantum phenomena, including, e.g., Bose–Einstein condensation and superfluidity, which makes them interesting both from a physical and a mathematical point of view.The goal of this project is the development of new mathematical tools for dealing with complex problems in many-body quantum systems. New mathematical methods lead to different points of view and thus increase our understanding of physical systems. From the point of view of mathematical physics, there has been significant progress in the last few years in understanding the interesting phenomena occurring in quantum gases, and the goal of this project is to investigate some of the key issues that remain unsolved. Due to the complex nature of the problems, new mathematical ideasand methods will have to be developed for this purpose. One of the main question addressed in this proposal is the validity of the Bogoliubov approximation for the excitation spectrum of many-body quantum systems. While its accuracy has beensuccessfully shown for the ground state energy of various models, its predictions concerning the excitation spectrum have so far only been verified in the Hartree limit, an extreme form of a mean-field limit where the interaction among the particles is very weak and ranges over the whole system. The central part of this project is concerned with the extension of these results to the case of short-range interactions. Apart from being mathematically much more challenging, the short-range case is theone most re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A novel approach to radiotherapy using gene transfer technology' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives:?In vitro sensitivity of BT4C glioma cells transduced with the HSV-tk gene to antiviral agents.?Selective radiosensitivity of BT4C-tk cells by antiherpes agents.?Determine the effectiveness of in vitro gene transfer of the HSV-tk gene for the treatment of BT4C glioma cells with antiviral pyrimidine and purine nucleoside analogues.?Determine the effectiveness of in vivo gene transfer of HSV-tk gene for the treatment of BT4C glioma in the rat brain with antiviral pyrimidine and purine nucleoside analogues.?Optimization of current viral vectors and development of novel vectors in order to improve gene delivery of the HSV-tk genome.?Determine the magnitude of the effect of antiherpes agents on the radiation response of BT4C glioma transduced in vivo with the HSV-tk gene.?Determine acute and late effects of critical normal tissues (brain).?Consider safety and toxicity aspects of antiherpes agents and radiation combination therapy in a sub-human clinical system - spontaneous gliomas in the dog brain.Brief description:It is estimated that in 1997, more than 40.000 new cases of central nervous system cancers will occur within the European Community accompanied by approximately 30.000 deaths.Malignant glioma of the brain is one of the most lethal cancers in humans. The median survival time after diagnosis is 50 weeks for glioblastoma multiforme. The majority of patients die of local recurrence, despite aggressive medical intervention including surgery, radiotherapy, and nitrosourea based chemotherapy.Recent attention has been focused on gene therapy of gliomas. One particularly appealing approach has been to incorporate the viral gene which codes for the enzyme thymidine kinase into the replicating cancer cell, so that the viral-derived thymidine kinase can toxify a s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DNA Replication Stress in Cancer' in the context of a Seventh Framework call.

assistant: **Objectives**

DNA replication is a crucial, but potentially dangerous process in every cellular division. A failure to maintain the integrity of replicating chromosomes leads to genome instability, an early event in tumorigenesis. Most common anti-cancer drugs also interfere with DNA synthesis, by largely undefined mechanisms. My lab specializes in the structural and molecular characterization of DNA replication stress in higher eukaryotes, combining standard cell and molecular biology with specialized single molecule analysis of replication intermediates.The first aim of our research is to gain mechanistic information about the elusive impact of oncogene activation on DNA replication. By direct structural analysis of tissue culture models of tumorigenesis, we have recently uncovered specific defects in DNA synthesis associated with DNA damage checkpoint activation. We plan to expand these studies to compare the effect of different oncogenes and to identify cellular factors modulating oncogene-induced genotoxicity.We are also elucidating the cytotoxic mechanisms of anti-cancer drugs that challenge DNA replication. Comparing the molecular consequences of chemotherapeutic treatments in control cells and cells lacking cancer-related factors, we plan to uncover how precisely different drugs interfere with replication and which cellular players mediate their cytotoxicity. We plan to complement these studies with a proteomic-based screen, to identify novel factors modulating replication of a damaged template.Finally, we plan to analyze replication features in different populations of stem cells, as the cellular response to replication stress was recently proven essential for stem cell maintenance. We aim to provide mechanistic insight into the constitutive activation of the DNA damage resp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advanced Multistage Sequential Wastewater Treatment Technology' (ANAERGY) targeting Horizon 2020.

assistant: **Abstract**

Enhancing of wastewater treatment technologies is a key goal of the EU to achieve sustainable and circular economy. Due to the required high investment and operational costs of current technologies, many industries find more economical to pay fines for direct discharges of polluted effluents than to treat them. Particularly, the heterogeneity and seasonality of the agro-food sector produce a broad variety of wastewater streams which claim for more efficient and customizable solutions to meet with increasingly stringent wastewater regulations.Within this context, Ingeobras and Proycon have developed ANAERGY, a modulable wastewater treatment system that integrates for the first time: anaerobic, aerobic and advanced oxidation stages. The exclusive design of the anaerobic digester, including patented PUREMUST® technology, enable to reach high pollutants elimination rates (95-99%) and production of biogas (16 m3/m3). Also, its small size and flexibility allow reducing installation and operational costs, together with a tailored response to end-user´s requirements. Following their collaboration for 12 years, Ingeobras will manage technical upgrades, assembly, commercialization and installation, while Proycon will be in charge of manufacturing the digesters. The adoption of ANAERGY by industries lead to major economic savings by eliminating wastewater discharge fees and reducing energy costs (biogas ≈80% energy needs). The benefits that ANAERGY will bring to the market will make the proposed project profitable with a ROI of 6.6 over 4 years and a payback period by the 1st quarter of the second year. Likewise, by improving current technology, ANAERGY will decrease water pollution, increase water reusability and strengthen renewable energy share. Together, these actions generate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identification of novel HIV-1 epitopes as vaccine candidates' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The aim of this project is to select peptide epitopes that mimic neutralization sensitive domains of HIV-1 envelope and may function as candidate HIV-1 vaccines. To date, efforts to develop a truly prophylactic HIV-1 vaccine have been hindered by difficult y in identifying immunogens that elicit broadly neutralizing antibodies. This lack of significant cross-protection raises further concerns on the capacity of classical Env-based vaccines to afford substantial protection against field isolates. Indeed, curr ent unmodified gp120 or gp140 envelope-based vaccines in human subjects have shown little or no protection from heterologous HIV-1 isolates such as would be encountered in the field. This indicates that vaccine trials with currently available immunogens wi ll afford low percentages of protection with a large number of vaccine breakthroughs and will raise ethical and financial issues concerning the treatment of any volunteers who become infected. It is of the highest priority that a focused effort is undertak en to develop novel Env antigens capable of inducing broad and potent neutralising antibodies to a wide variety of strains. Consistently, this consortium is developing a new generation of Env antigens based on complex but conserved epitopes to induce broad neutralising antibodies. This objective will be achieved by two complementary strategies: a. Screening of Random Peptide Libraries with novel MAbs that neutralise primary HIV-1 isolates assigned to distinct clades; b. designing of 30-40 amino acid peptide s that mimic discontinuous regions of gp120 and gp41 that are sensitive to neutralization by antibodies and are conserved among HIV strains of distinct clades. These include the CD4-binding domain, the bridging sheet and the pre-fusogenic harpin loop of gp 41
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Reuse of excavated soil in 3D printing of sustainable earth-based mixtures for low energy buildings' (RePrintCLAY) targeting Horizon Europe.

assistant: **Abstract**

Modern construction materials are energy-intensive, and therefore, the construction industry can reduce emissions by developing alternate building materials and adopting innovative construction technologies. There is an upsurge of interest in earth building technologies, but there are associated limitations such as labour cost and construction time. On the other hand, the construction and demolition of infrastructure produce a surplus of excavated soils that ends up at landfills. In this scenario, processing these soil wastes locally and integrating them in buildings as earth-based construction materials using 3D printing technology is an ideal solution. Therefore, the project assesses the technical feasibility of reusing the excavated soil, for producing earth-based composites, with sustainable additive combinations for enabling 3D printing.  An industrial by-product such as Ground Granulated Blast-furnace Slag (GGBS) is proposed as an additive with other inorganic admixtures in trace quantities for treating the soil. The rheological parameters, the time-dependent green strength development characteristics and the long-term compressive strength characteristics of the soil treated with additives will be studied. The microstructure of the hardened earth mixes will be used for explaining their mechanical performance. The project will deliver promising earth mix combinations that are environmentally friendly, printable and made from by-products resources and excavation soil wastes. The outcomes of the project will be instrumental in delivering the decarbonization goals of the construction industry. This project is supported by the excellent research environment provided by the host, Dr Perrot at UBS and Prof. Habert at ETH Zrich, with state-of-the-art facilities for resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Image supramolecular binding processes on the molecular level by STM for fundamental understanding sensor' (2007-2013).

assistant: **Innovation**

The goal of the project is to image supramolecular binding processes on the molecular level with the purpose to gain fundamental understanding of how a sensor operates. This understanding will subsequently be applied as a basis for new sensor design.Scanning Tunneling Microscopy (STM) will be used to visualize single molecule binding events of analyte molecules to receptor molecules adsorbed at a surface. In addition to topography changes,  STM will also give valuable information about changes in electronic properties of the receptor upon the binding. This information will be used in the design of new, extremely sensitive sensors based on carbon nanotubes and graphene. The highly interdisciplinary research will be carried out by a promising young European researcher at MIT (USA) under the supervision of Prof. T. M. Swager, and at the Eindhoven University of Technology (the Netherlands) in the group of Prof. R. A. J. Janssen.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New Drying Techniques for Moulded Fibres', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

ProblemDisposable plastic bottles are an increasing threat to our environment. 50 billion water bottles alone are consumed every year and 80 % of all plastic bottles end up in landfills. EcoXpac owns the technology to produce a 100% biodegradable bottle – the Green Fibre Bottle.SolutionThe fibre material is not new in itself, but so far it has not been possible for packaging manufacturers to produce a bottle at a competitive prize - primarily due to the extremely energy consuming and complicated drying process and long production cycle. EcoXpac owns the rights to an energy saving impulse-drying technique that will disrupt the market for moulded fibres. The technique will make it possible to replace all kinds of plastic products with biodegradable fibre products.The projectProof of concept has so far been achieved in a test facility. The purpose of the current project is to prepare the construction of an impulse drying process facility at a larger and more advanced scale that can serve as a demonstration plant. The innovation in this project has the potential to revolutionize the packaging industry in the same way as Tetra Pak did. The customerThe end customers will be large manufacturers of Fast Moving Consumer Goods. The business model of EcoXpac is to sell the rights to use the fibre bottle within a specific end-user segment, e.g. dairy products, to global manufacturer and then work closely with the packaging manufacturer to customize the production line to their needs.The teamThe team behind EcoXpac possesses high-expertise in moulded fibre process technology and a proven commercial track record. EcoXpac works in close collaboration with the biggest dairy producer in Scandinavia, Arla Foods, about the development of a fibre bottle for Arla Foods products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Firm Networks Trade and Growth'.

assistant: **Innovation**

The general theme of this research is to introduce the notion of large-scale economic networks into the mainstream of economics, in particular in macroeconomics and international trade. Economic agents often do not have access to all the relevant information they may need: whom they know, whom they interact with represents a small fraction of all possible interactions. I model this limited set of interactions as a network: agents are nodes, and they only interact with other agents they have formed a link with. What is the shape of this network of linkages between agents, and how does it evolve? More importantly, what are the aggregate implications of the shape of this network? These are the broad questions I will address in this research. I will consider six specific applications of this unifying idea in various fields: international trade, IO, macroeconomics and growth. In international trade, we have only a very crude understanding of the frictions that prevent most firms from exporting. I propose to model trade frictions as a dynamic network: at a point in time, a given exporter only has information about a limited set of potential customers in a few foreign countries; over time, this exporter discovers new export opportunities, and its network of customers evolves dynamically. I offer theoretical and empirical tools to understand and analyze the properties of this network, and show how it shapes aggregate trade patterns. In IO and macroeconomics, most plants only have few suppliers. I will model the input-output linkages between plants as a dynamic network; I offer theoretical and empirical tools to analyze this network, and show how it shapes the propagation of plant level shocks to generate aggregate fluctuations. Human capital accumulation is key to economic grow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Roberta goes EU' (ROBERTA-EU) under Sixth Framework.

assistant: **Objectives**

Roberta-EU addresses the lack of female engineers by raising girls' interest for technical professions. Roberta-EU uses robotics as a holistic approach to gain knowledge in IT, electrical engineering, and mechanics. Courses are tailored towards gender related issues using robot construction kits offer hands-on experience.This setting is well suited to create interest and even enthusiasm for technical subjects. Roberta-EU provides training courses and comprehensive teaching materials for primary and secondary school children. The objective of Roberta-EU is to promote the best practice experience made in the German Project Roberta to the European level.The main objectives are- Set-up a dissemination network of regional centres to promote the ideas behind Roberta to several European countries.- Teach the teachers to use of robot construction kits in schools as a means to teach interdisciplinary technical contents especially - but not only - for girls- Assess, document and evaluate the experiences made in courses performed in these regional pilot centres.- Promote the inclusion of these didactic course elements into national curricula.The Roberta-EU network will connect already established activities. Activities should focus under the brand Roberta in order to propagate technical education in the public and towards curricula. Roberta-EU includes an advisory board. The members of the advisory board are well-recognized people in the field and will give publicity and prestige to the project.They will propagate Roberta-EU in their countries by finding appropriate regional centres, by giving advice in order to consider local peculiarities (school system, culture), and by supporting the introduction of Roberta methods to national curricula.