RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cellular and molecular mechanisms of pancreatic beta-cell adaptation to pregnancy in large mammals.' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Pregnancy is characterized by the development of maternal insulin resistance and increased hepatic glucose production to provide sufficient glucose to be used as nutrient by the developing fetus. The maternal insulin-producing beta-cells expand to counterbalance the increased glucose levels and failure of this process can lead to development of gestational diabetes, which has great health implications for both the mother and the developing fetus. Yet, our knowledge on the mechanisms behind the pregnancy-induced beta-cell expansion in humans is limited. To address this knowledge gap, in the betaPPreg project, I will use the pig model as an ideal surrogate large mammal to study the mechanisms and identify physiological drivers of pregnancy-induced beta-cell expansion. First, I will identify the extent and the different cellular mechanisms of beta-cell adaptation in the porcine pancreas over the three trimesters of gestational time (~114 days) by histological analysis. To reveal the physiological candidates of beta-cell adaptation, I will perform untargeted metabolomics coupled with proteomics analysis of serum and pancreas at sequential temporal windows during gestation. This analysis will point to the significantly changed metabolites and growth factors that can be potentially involved in beta-cell expansion. I will perform a small-scale metabolite/growth factor screen in isolated neonatal porcine islets with the most regulated factors, to causatively link the metabolites/growth factors stimulating beta-cell expansion. The most promising candidates will be then tested in isolated human islets and human-derived ductal organoids to assess their translational potential as beta-cell proliferation/differentiation inducers and human therapeutics. Overall, the proposed project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Riding on Moore's Law' in the context of a Seventh Framework call.

assistant: **Objectives**

The most common interpretation of Moore's Law is that the number of components on a chip and accordingly the computer performance doubles every two years. At the end of the 20th century, when clock frequencies stagnated at ~3 GHz, and instruction level parallelism reached the phase of diminishing returns, industry turned towards multiprocessors, and thread level parallelism. However, too much of the technological complexity of multicore architectures is exposed to the programmers, leading to a software development nightmare.We propose a radically new concept of parallel computer architectures, using a higher level of abstraction, Instead of expressing algorithms as a sequence of instruction, we will group instructions into higher-level tasks that will be automatically managed by the architecture, much in the same way superscalar processors managed instruction level parallelism.We envision a holistic approach where the parallel architecture is partially implemented as a software runtime, and the reminder in hardware. The hardware gains the freedom to deliver performance at the expense of additional complexity, as long as it provides the required support primitives for the runtime software to hide complexity from the programmer. Moreover, it offers a single solution that could solve most of the problems we encounter in the current approaches: handling parallelism, the memory wall, the power wall, and the reliability wall in a wide range of application domains from mobile up to supercomputers .We will focus our research on a most efficient form of multicore architecture coupled with vector accelerators for exploiting both thread and data level parallelism.All together, this novel approach toward future parallel architectures is the way to ensure continued performance impro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European plant genome database network (PLANET)' (PLANET).

assistant: **Innovation**

Due to a number of national and European efforts a wealth of highly valuable plant genome related information would be generated during the coming years. To integrate this information and to bridge the information flow between the national communities, the objective is to establish a network of data resources, bioinformatics tools and experts from nodes representing national plant genome efforts to create a comprehensive, distributed European plant genome database as an indispensable resource. The project will strongly benefit from the existing databases and bio informatics groups and build on the already establishedArabidopsis genome database.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Live biotherapeutics to potentiate cancer immunotherapy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Immunotherapy, including immune checkpoint inhibitors (ICIs), has revolutionized the treatment of multiple cancers. Anti-tumor responses are often durable but overall only a subset of patients receiving ICIs has exhibited sustained tumor shrinkage, whereas a substantial fraction receiving these therapies develops immune-related adverse events. The absence of dramatic responses is attributed to several factors, including abnormalities in the tumor microenvironment (TME). Specifically, many tumors such as subsets of colorectal, breast and pancreatic cancer, become stiff as they grow. Tumor stiffening causes compression of intratumor blood vessels, impairing blood flow/perfusion and oxygen supply. Hypoperfusion reduces ICIs delivery to the tumor and hypoxia induces immunosuppression, compromising immunotherapy. To restore these abnormalities, a novel therapeutic strategy to normalize tumor stiffness prior to ICIs has been tested in preclinical studies and in the clinic. This strategy repurposes clinically approved drugs to target the factors contributing to tumor stiffening, leading to a new class of therapeutics, known as mechanotherapeutics. However, drug-repurposing poses certain limitations as adding a new drug to the treatment regimen of patients with cancer is not feasible in many cases. As an alternative to these approaches, we propose here to test the ability of engineered live biotherapeutics in the form of programmable bacteria that offer unique advantages for delivering enzymes to normalize the TME. Even a small fraction of bacterial dose reaching the tumor is sufficient to colonize it and allow therapeutic concentrations of tumor-remodeling enzymes to be maintained for a long period of time. We propose to evaluate the ability of a novel live biotherapeutic prod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Integrated Micro-Nano-Opto Fluidic systems for  high-content diagnosis  and studies of rare cancer cells' in the context of a Seventh Framework call.

assistant: **Objectives**

The project aims at developing a new integrated and automated microfluidic tool for cancer cells screening. This instrument will have a reliability and power much beyond state of the art (capture yield increased by a factor from 10X to 100X and multimodal typing of the cells in 3D high resolution images), allowing earlier and more accurate diagnosis, prognosis and selection of treatments of cancers. CaMiNEMS’s new approach will involve a new generation of bio-functionalised multifunctional magnetic nano and microparticles which will be self-assembled by a Hierarchial Templated Self-Assembly mechanism into high-aspect ratio reversible arrays. For highly automated molecular typing of cancers, this key innovation will be integrated with a unique fully automated flow control system working from nanolitres to millilitres and with innovative nano-optics tools and image analysis software.  Technological developments will be validated regarding the analysis of circulating tumour cells or “micrometastases” and the molecular typing of minimally invasive microsamples from tumours. The project will also yield new tools for research and drug-discovery, allowing for the first time to study at the single molecule scale in single cancer cells from patients the fate and action of new generation anticancer drugs using innovative dynamic tracking of Quantum dots.  To combine research excellence and societal impact, the consortium involves research groups with complementary competences in microfluidics, nano-optics, biophysics, nanoparticles, biochemistry, informatics, several forefront cancer centres for clinical validation and a research-intensive SME for exploitation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The 26S Proteasome : A New Target for Drug Discovery' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The objectives of the proposed studies are to use biochemical, protein structural, enzymological and molecular biological techniques together with the power of yeast genetics to characterise fully the intracellular protease called the 26S proteasome. The information gained in the programme will form the basis for the design and development of compounds which have great therapeutic potential for a variety of acute and chronic human and animal diseases. The 26S proteasome is the major intracellular non-lysosomal protease involved in the degradation of proteins. The 26S proteasome works in part in conjunction with the cellular protein ubiquitination and ubiquitination systems. The combined proteolytic systems serve to continually degrade cellular proteins. The ubiquitin/26S proteasome system is critical for the regulated degradation of transcription factors, cell cycle regulators, and the generation of protein fragments for class 1 antigen presentation in addition to regulating the general degradation of many cellular proteins The 26S proteasomeis composed of a proteolytic 20S cylindrical core together with regulatory subunits. There are two types of regulatory complex, the 19S and 1 1 S regulators. These regulators sit on the ends of the cylindrical core and regulate the access and degradation of target proteins. The consortium will study the structure and function of the ATPases and the non-ATPases which are part of the 19S regulating complexes of the 26S proteasome. Developmental control of the regulatory subunits in model systems and in human tissues will be central to the studies. Additionally, the power of yeast genetics will be employed in order to understand the phenotypes generated by mutations in the ATPase and non-ATPase regulators. Phenotypic changes in the hig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Robotics Algorithms for Computer Animation'.

assistant: **Concept**

On one hand, the Computer Animation community focuses on the Virtual Human model and control. Generic methods for interacting with the digital actors are available, allowing an animator to drive them with a set of programmable actions. On the other hand, t he Robotics community has developed techniques and algorithms to increase the autonomy of robots. Particularly, the community is at the origin of the motion planning methods, and more specifically of those based on the Probabilistic Roadmaps Method. Recent ly, combinations of motion planning techniques and computer animation techniques appeared in the related literature, providing a solution for planning the motion of virtual actors. First results are promising but the abilities of these solutions is yet lim ited. The main objective of the RAGA project is to extend the functionalities of such solutions. Particularly, one goal of the proposal is to allow the automatic synthesis of animations in which the virtual actors is achieving simultaneously several tasks, such as reaching and grasping an object of the environment while walking. Of course, the motion of the actor must also satisfy the constraints related to the presence of obstacles of the environment possibly cluttered. I spent a PhD thesis in the Robotics community on the problem of the locomotion planning of virtual actors in cluttered environments. The RAGA project is an opportunity to leverage my Robotics know-how and foster its potential through mastering the unique Computer Animation techniques (and d evices) developed at the Virtual Reality Laboratory of the Ecole Polytechnique Federale de Lausanne (EPFL, Switzerland). The realisation of the project should open a clear perspective in this research direction, in which I intend to pursue my career as an inde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Regional Digital Agendas for Healthcare' (2007-2013).

assistant: **Innovation**

READi for Health aims to strengthen the research potential of four leading eHealth regions (Murcia, Skane, Oulu and Midi-Pyrénées) by supporting their triple helix clusters to become world-class players in domains related to the EU Digital Agenda for Healthcare.The major limitation of the eHealth market today is not scarcity of technology, but that innovationup-take is slow compared with other sectors not depending on Public Administration. As a consequence,European public sector expenditure has not been used to spur innovation. However, with an aging population and under current economic conditions, it is critical to facilitate its incorporation to raise the efficiency and quality of healthcare delivery.READi for Health clusters will join forces to prepare and specialize their regions for quick uptake of eHealth innovation, validation under real-world conditions, and cost-benefit assessment. Cutting-edge companies (even from other regions) will be welcomed to apply for technology testing within the mature Healthcare Information System regional landscapes of the consortium and, if considered of public interest, supported in its implementation and economic assessment.For this to become a reality, new Public Private Partnerships and purchasing mechanisms like Pre-Commercial Procurement need to be used. Also, technological development tofacilitate quick incorporation of innovation has to be fostered. In particular in the areas of:•Semantic Interoperability and Standards.•Cloud Computing.•Secure information access from any device.In order to become a truly regional engine for growth, those innovations must be exported to European and world-wide markets. Participants will support companies, especially SMEs, to internationalize their innovations by promoting a ´global network
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Microbial genome defence pathways: from molecular mechanisms to next-generation molecular tools'.

assistant: **Innovation**

The constant arms race between prokaryotic microbes and their molecular parasites such as viruses, plasmids and transposons has driven the evolution of complex genome defence mechanisms. The CRISPR-Cas defence systems provide adaptive RNA-guided immunity against invasive nucleic acid elements. CRISPR-associated effector nucleases such as Cas9, Cas12a and Cas13 have emerged as powerful tools for precision genome editing, gene expression control and nucleic acid detection. However, these technologies suffer from drawbacks that limit their efficacy and versatility, necessitating the search for additional exploitable molecular activities. Building on our recent structural and biochemical studies, the goal of this project is to investigate the molecular architectures and mechanisms of CRISPR-associated systems and other genome defence mechanisms, aiming not only to shed light on their biological roles but also inform their technological development. Specifically, the proposed studies will examine (i) the molecular basis of cyclic oligoadenylate signalling in type III CRISPR-Cas systems, (ii) the mechanism of transposon-associated type I CRISPR-Cas systems and their putative function in RNA-guided DNA transposition, and (iii) molecular activities associated with recently described non-CRISPR defence systems. Collectively, the proposed studies will advance our understanding of the molecular functions of genome defence mechanisms in shaping the evolution of prokaryotic genomes and make critical contributions to their development as novel genetic engineering tools.


**Keywords:** CRISPR-Cas, transposons, nucleases, DNA helicases, genome editing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Envisioning an integrated quadruple helix and RRI framework for food system transformation and regional innovation ecosystem enhancement' in the context of a Horizon Europe call.

assistant: **Objectives**

VISION4FOOD aims to enhance the sustainability and resilience of EU food systems through the development of innovative governance models that contribute to better informed decision-making processes while promoting social engagement and innovation in 5 European regions (Finland, Spain, Italy, Greece, Poland) with different innovation ecosystem maturity levels. Through the project, our regions will be supported to strengthen their role in the creation of Food Innovation Platforms (FIPs), fostering collaboration among Quadruple Helix stakeholders and facilitating the identification, and scaling of innovations for food system transformation. The methodology involves co-creating R&I strategies, emphasizing open science, and Responsible Research Innovation (RRI). Through VISION4FOOD multi-stakeholder approach and the integration of tools and services we will provide them all the necessary support for knowledge exchange, networking and priority setting in the form of an acceleration agenda tailored to each region’s priorities and needs while facilitating the transition to an innovative and inclusive food system. We will closely monitor and evaluate the performance of the governance models’ operation, providing evidence of its  impacts.


**Keywords:** RRI tools, new governance models, open innovation, cross regional knowledge transfer, awareness and empowerment, quadruple helix models, food innovation platforms, healthy and sustainable food systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Adaptation of renewable energies technologies for the olive oil industry'.

assistant: **Objectives**

The European olive oil sector is nowadays facing several stresses that push towards a new approach to production. Despite worldwide consumption rises; new producer countries enter the markets and increase competition, threatening European producers’ position. Besides, the high polluting character of its residues, poses serious problems to the olive mills, especially in the case of small and medium ones. All the groups involved agree on the need for a more sustainable approach to production, where environmental conditions are taken into consideration without damaging productivity.  Even though efforts have been made so far for bringing the results obtained to practice, many local producers associations still lack a clear guidance adapted to their needs in specific fields, resulting in giving up the implementation of these activities after the institutional support is over. The proposing IAGs intend to take an integrated and more proactive approach to the problem: This polluting charge of olive mill waste (OMW) can be taken as an advantage to produce energy: OMW has many uses in renewable energy: it can, for instance, be gasified to obtain hydrogen, digested in an anaerobic process to obtain methane, or directly used in combustion. RESOLIVE will also explore other processes to obtain a valuable outcome from olive mill residues: solar distillation, composting, etc. The main objectives of the proposed project are: - To define the needs for the implementation of renewable energy solutions specific to the olive oil industry and proceed to test in practice their performance.  - To create a comprehensive set of guidelines that will advice the associates of olive oil producers’ cooperatives deciding which of the available options for the implementation of renewable energy suits