RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'PANTOgraph and catenary interaction Total Regulatory Acceptance for the Interoperable Network', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The current interoperability approval process for new High Speed and Conventional railway vehicles in Europe is a very long and costly process. The Technical Specifications for Interoperability provide common regulations for the homologation of new rolling stock but do not directly eliminate the current burdens regarding new vehicle approval on each network. In this context, the pantograph/catenary system represents one of the major barriers to rolling stock interoperability. Indeed, each country has developed its own overhead line equipment leading to different catenary designs with variations in mechanical properties. A unified approval method is a key subject that must be addressed to provide a competitive railway system. Hence, PANTOTRAIN proposes to transfer the pantograph/catenary certification from current line testing towards laboratory testing and simulation. This will improve pantograph interoperability, increase train performances on the existing infrastructure and achieve considerable costs and time savings for the homologation of new pantographs The project is part of the TRIO-TRAIN cluster (Total Regulatory Acceptance for the Interoperable Network) which comprises 3 related projects dealing with key railway interoperability issues: Aerodynamics (AEROTRAIN), Railway Dynamics and Track Interaction (DYNOTRAIN) and Pantograph/Catenary Interaction (PANTOTRAIN) all submitted under the 2nd Call of the FP7. The objective of these projects is to propose an innovative methodology via a computer simulation/virtual homologation that will allow multi-system network and route approval in Europe to become a faster, cheaper and better process for all involved stakeholders. Therefore the success of the TRIOTRAIN cluster will lead to a time reduction for relevant parts of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Centre for New Methods in Computational Diagnostics and Personalised Therapy' (Sano) under Horizon 2020.

assistant: **Objectives**

This proposal describes the creation in Kraków, Poland, of a centre for Computational Medicine. The Centre will be a major driver for European advancement in this rapidly growing sector, developing sophisticated engineering methods for the prevention, diagnosis and treatment of disease, and meeting the overarching worldwide need for radically streamlined healthcare systems. The Centre’s area of operation will be computational medicine:(1)Clinician-led activity can be radically reduced by migrating the majority of routine clinical assessments toward computationally-driven (2) Entirely new approaches to disease diagnosis and management follow the development of novel computed biomarkers of disease, personalised to the individual patient, and typically leading to dramatically reduced costs. The Centre will combine expertise in machine-learning based decision science with fundamental biomarker identification using advanced simulation and data analysis methods. The Centre will act as a core technology provider for industry, fostering modernisation, innovation and increasing productivity, and additionally it will act as a catalyst, attracting new investment and businesses. It will provide an essential link between computational, medical sciences and the industrial sector, thus fostering knowledge and technology transfer and accelerating innovation. The Centre is to be established in Kraków because of several local advantages with regard to the education and research infrastructure, the high concentration of research hospitals and a dynamic entrepreneurial community in life sciences, so being embedded in a highly dynamic and competitive ecosystem The Centre will provide a fully sustainable mix of three advanced technical services, loosely categorised as education, project part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'EU Community' to be submitted under Seventh Framework.

assistant: **Abstract**

EU COMMUNITY MERGES ICT AND SOCIAL MEDIA NETWORKING WITH ESTABLISHED ONLINE MEDIA AND STAKEHOLDER GROUPS TO CULTIVATE TRANSPARENCY, ENHANCE EFFICIENCY AND STIMULATE FRESH IDEAS FOR EU POLICY-MAKING.<br/>THREE CHALLENGES are identified to reduce complexity and leverage under used technologies.1. Ever more complex policy processes, thousands of contributors and documents, not easily understandable by people. REQUIRE reputation ranks and relevance filters;2. eGov projects grow locally but have limited EU impact due to language, interface and trust barriers. REQUIRE co-development with stakeholders, leveraging visualisation technologies such as curated timelines;3. Social media is prevalent but not helping EU legislation-making yet (except blocking ACTA).<br/>NOVEL APPROACH: over 36 months, a consortium of leading research centres, ICT SME's and a large media network, will go from existing tools to further advanced prototype, pilot-testing and roll-out. They are supported by a number of high-calibre experts and a foundation serving as community guarantor. The results will be tested and deployed over an EU policy media network, with a track record of sustainability and multilingualism. Three pilots suiting the EU political mandates 2014-2019 have been selected (FUTURE OF EU, RENEWABLE ENERGY and INNOVATION STRATEGY) and will be undertaken by a network of European stakeholders (policy-makers, journalists, experts, NGO's and informed citizens) in several EU countries, supported by localised policy media.<br/>OBJECTIVE: EU Community goes beyond current generation of policy modelling and argumentation tools. It provides decision makers with better policy options by combining social media interactions, qualified contributors, document curation, visual analysis plus online and off
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Conjugated linoleic acid (cla) in functional food: a potential benefit for overweight middle-aged europeans' (FUNCLA) under Fifth Framework.

assistant: **Objectives**

Chlorate is present in effluents from various industrial processes. If not removed, harmful chlorate ends up in surface waters and groundwater and eventually can even be found in drinking water. The aim of this research is to characterize the (facultative) anaerobic microorganisms that are able to convert chlorate completely to chloride, and to investigate their applicability in reactor systems. The main objectives are to investigate the diversity, physiology, biochemistry and the genetics of chlorate-reducing microorganisms and to investigate their chlorate-removing capacity and their stability in reactor systems. This research should generate knowledge for the anaerobic microbial treatment of chlorate-containing waste-systems, thereby preserving the quality of water. The results are expected to be used also for the detoxification of other harmful ox-anions like chlorite, per chlorate, bromated, arsenate and serenade.From the animal experiments, we may conclude that:-Adult rats fed ad libitum are less responsive than growing rats to the fat-reducing or growth-promoting effect of these CLA isomers. This suggests that longer experiment could be necessary but this is questionable inasmuch as no trend related to the effect of CLA feeding on body composition changes was observed. However, this does not mean that CLA isomer had no effect on lipid, protein or energy metabolisms in adult rats since metabolic rates can be altered without consequence on body composition and such aspects deserve further studies to elucidate the real impact of these compounds on major metabolic pathways.-Exercise training do not enhance the putative effects of CLA intake in our experimental conditions The ingestion of pure CLA isomers, but the t10,c12 CLA isomer to a greater extent, increased tiss
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'regulation of B-cell Epitope migration and Autoimmunity by T follicular helper cells' (BEAT).

assistant: **Innovation**

The detection of autoantibodies typically appear a few years prior to clinical autoimmune disease and their reactivity can drift at or after disease onset. The laboratory of M.C. Carroll (outgoing institute) has developed a murine model (ARTEMIS; Autoreactive B-cell driven T-dependent Epitope Migration towards Immunity to Self) where the presence of a single autoreactive B cell clone drives activation, expansion and differentiation of other autoreactive B-cells in spontaneous germinal centers (GC) followed by autoantibody deposition in the kidney. These autoreactive B-cells target multiple other self-antigens (also known as epitope spreading) and are independent of the initial trigger once tolerance is broken. Follicular T helper (Tfh) cells play a prominent role in the selection of B-cells in the GC and have been linked to excessive GC formation, high-level production of pathogenic autoantibodies and end-organ damage in murine and human autoimmune disease. With this project I will address the role of Tfh cells in the maturation process of the self-reactive B-cell response and epitope spreading as observed in human autoimmune disease. Preliminary results show dependence of T cells, the extent and nature of T-cell involvement is however not yet addressed. I will utilize the mixed bone-marrow chimera model (ARTEMIS) in combination with selected strains altered in important factors for Tfh function and differentiation. As the GC reaction is a highly dynamic process we will visualize this utilizing multi-photon intravital microscopy and analyze important interactions of Tfh cells in the developing autoreactive GC. The development of autoreactivity from WT B-cells in the ARTEMIS model better reflects natural autoreactive GC behavior and human autoimmune disease and could the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Self Mobility Improvement in the eLderly by counteractING falls' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Mobility means freedom, flexibility and autonomy for all citizens, including older persons. Aging is characterized by functional changes that can create gait and balance disturbances in elderly, which are the main risk factor for falling. Elderly at risk of falling can be considered to be suffering from an involuntary motor behaviour that restricts their participation in society. One method to overcome such a situation is to activate a new learning process to better approach real life tasks, which represents an innovative element. The SMILING project is planning to diminish age related impairments by interfering with mobility disability and improving carry-over into real life situations. The new approach is intended to challenge the patient to solve new motor problems in real time by inducing variable environments that need active response and problem solving from the target population. This multidisciplinary project will offer a reorganization of the rehabilitation process in ageing, through new training procedures and advanced technologies needed to deliver them. The SMILING solution, a wearable computer-controlled device, is aimed to implement a systemic solution to re-model training sessions used prevalently in fitness clubs to facilitate and ameliorate walking schemas. The end-users needs will be assessed and they will participate to the all phases of the project. Special attention will be given to the acceptance and usability of new technology. The final product will improve mobility and functional status of target populations significantly prolonging independent living, increasing active participation in society across prevailing age-related impairments, and provide mobility aspects of active ageing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Moduli Spaces associated with Singularities' (ModSingLDT), addressing dissemination and exploitation.

assistant: **Impact**

The aim of this project is to investigate enumerative invariants of the Hilbert schemes parametrizing zero-dimensional subschemes of some basic classes of surface singularities as well as of its higher rank analogues, and find connections between these enumerative invariants and the Chern-Simons theories on the links of the singularities. This question will open brand new relations between algebraic and topological invariants of these singularities. The main tool to approach the problem will be to develop representations of vertex algebras on the cohomologies or derived categories of these moduli spaces conjecturally giving rise to analogues of the Nekrasov parition function on the singularities. Then we will use recent new developements about a specific motivic measure with values in the Grothendieck ring of geometric dg categories to prove some simplification of the aimed correspondence. In the end we will raise these simplified results to the general level.This project will allow the researcher to broaden his area of expertise as well as to develop new directions in his research lines. He will complement his knowledge in low-dimensional topology at one of the most prestigious research institutes and under the guidance of one of the worldwide leaders in this field.


**Keywords:** Hilbert scheme of points, normal surface singularities, vertex algebras, Nekrasov partition function, Chern-Simons theory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Studies of the dna/cationic lipids complexes formed by langmuir-blodgett method - structural investigation by neutrons and x-rays diffractions' under Fourth Framework.

assistant: **Concept**

Research objectives and content Cationic liposomes complexed with DNA are among the most promising non viral carrier vectors for gene therapy. Recent investigations by Radler reveal a novel multilamellar structure of cationic lipid/DNA complexes with alternating lipid bilayers and DNA monolayers. The aim of this project is to design similar arrangements by the Langmuir-Blodgett (LB) method and to investigate their nanostructure by complementary techniques: neutrons scattering, synchroton X-ray diffraction, electron and optical microscopy. Systematic studies of physicochemical parameters would give insights into the driving forces of the formation of the gene vectors and would contribute to improve gene therapy efficiency. In this project, our proposal consists in: i) continuing the recent investigations of lipid/DNA and lipid/DNA/polypeptide gene transfer complexes in collaboration with the medical group of Moradpour and Blum (Freiburg, Germany). The transfection efficiency will be related to their molecular structure. ii) investigation of interaction forces and basic molecular self-assembly principles in lipid/DNA complexes using oriented liquid crystalline probes in LB films. Training content (objective, benefit and expected impact) - Various and complementary techniques will be used for this study - In the laboratory: specialised optical microsocopy, DSC, electron microsocopy, ... - In different places in Europe: synchrotron X-rays and neutrons scattering experiments - New samples will be prepared by the Langmuir-Blodgett techniques. - A structural approach of the DNA/Cationic lipids complexes will get insight into the driving forces of complexes formations, and their stability during gene transfection therapy. Links with industry / industrial relevance (22) This wor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Modular 100% Carbon Fibre Footbridge' (MODBRIDGE).

assistant: **Innovation**

Our MODBRIDGE project aims to develop and automate an industrial manufacturing process covering the whole supply chain for the production of modular 100 % CFC footbridges, which will enable to reduce production costs of CFC while obtaining a product with outstanding performance: our footbridges consist on 3 m long modules which can be assembled to reach lengths of up to 18 m, which have a load capacity close to that of concrete with a structure that is 20 times lighter. Moreover they are highly resistant to weathering and corrosion from environmental conditions, requiring zero maintenance for the first five years. In addition, its modular nature (with stackable modules to facilitate storage and transportation) and its light weight enable a simple and rapid assembly/disassembly (1 day for an 18 m long MODBRIDGE) and thus the reutilization of the product as many times as wanted, representing a much more cost-effective solution than traditional footbridges based on steel or concrete.Based on these characteristics, MODBRIDGE represents an excellent solution to be used in cities for the enhanced mobility of vulnerable road users, i.e. cyclists and pedestrians, over traffic or architectural obstacles with a minimal installation impact or for temporary events like trade shows, concerts or exhibitions. Moreover, the automation of our production will allow us to even its price to those of traditional solutions (€ 6,000 /unit vs. € 5,840 /unit for steel or € 5,675 /unit for concrete), increasing its cost-effectiveness: our installation and maintenance costs are much lower and our product requires a single investment instead of facing recurring costs.Considering that MODBRIDGE is aimed at the civil construction sector (mainly municipalities, local administrations, etc.) and the te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Early stage training in infectious diseases involving intracellular pathogens' to be submitted under Sixth Framework.

assistant: **Abstract**

Infectious diseases are responsible for major health, societal and economical problems in Europe and developing countries.The aim of this project is to give early stage European scientists a wide multidisciplinary training concerning intracellular pathogens. With 40 % of its research activity devoted to infectious diseases, the Pasteur Institute is an ideal place to train early researchers in this field.This programme will provide a unique PhD training promoted through:- courses in multidisciplinary basic science and key methodologies;- complementary skills training;- laboratory research.They will use cellular, molecular, genetic and genomic approaches to dissect critical interactions between intracellular bacteria and viruses, and their host during infection. The group leaders involved are internationally highly recognised experts in their field. The intracellular pathogens studied in this programme are major societal issues, both causing important human health problems, and also being environment and industry-related issues.The intracellular bacteria are:- Shigella, causing bacillary dysentery;- Legionella, an environmental bacterium that colonizes water circuits;- Listeria, which causes human diseases and food industry problems;- Chlamydiae, that causes lung and eye infections, and sexually transmitted diseases, with severe consequences in women.The viruses are: the Dengue virus, an emerging disease, endemic in most urban centres of the tropics; hepatitis C, a major health problem in Europe; HTLV-1, that may lead to leukemia, or inflammatory syndromes; and HIV-1 that may lead to AIDS.This program will:- move our understanding of intracellular pathogens to a new level;- provide a new generation of well-trained scientists to advance European research and who can partic