RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Learning by Experimentation' (XPERO).

assistant: **Concept**

The overall objective of the proposed project is to develop an embodied cognitive agent, which is able to conduct experiments in the real world with the purpose of gaining new insights about the world and the objects therein and to develop and improve its own cognitive skills and overall performance. It is obvious that for the ability to conduct experiments in the real world, embodiment is a fundamental prerequisite.Expected results of the project are basic models, techniques, and system solutions, enabling an embodied agent to autonomously design and conduct experiments in a given context - stimulating the agent's desire to gather new knowledge - and to extract new insights from the results of the experiment.XPERO proposes to approach this problem by developing a methodology for learning by experimentation. Enabling an embodied agent, in the sequel called robot, to design and conduct experiments in a natural real world setting and to extract new insights is more than just adding another feature to a technical system. The ability to conduct experiments in the real world and extract new knowledge and insights pushes open the door to a new quality of embodied systems namely to potentially unlimited autonomous learning. This ability enables the robot to grow in an unlimited fashion its cognitive capacity and its performance to accomplish meaningful tasks in the real world. Limitations are only set by the surrounding world and its own physical capabilities, and not by availability of a programmer, teacher or learning material. We plan to achieve this objective by performing research and development in the following areas Stimulation of Experiment, Design and Execution of Experiments, Observation and Evaluation of Experiments, Representing Knowledge and Gaining Insights,  an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ontology driven Open Translation Environment' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

OntoTrans provides an ontology-based Open Translation Environment. Its Artificial Intelligence approach enables end users to represent in a standard ontological form their manufacturing process challenges and to connect them with relevant information sources and materials modelling solutions, capable to support optimal materials and process design. OntoTrans provides smart targeted guidance through the whole translation process, namely from the initial user case specification to actual materials modelling workflows with related validation, verification and uncertainty quantifications to deliver a full complete experience to companies. This is achieved via analysis of available data (data fusion), modelling workflow options, simulation and contextual results interpretation. OntoTrans is fully integrated into existing and emerging developments in materials and manufacturing, including integration with digital materials modelling marketplaces and open simulation platforms. Its footing on the European Materials Modelling Ontology ensuring wide interoperability and standardisation. OntoTrans is developed and tested alongside four industrial challenges covering different types of materials and industries, targeting increased competitiveness by means of a semantic data-driven and agile approach.


**Keywords:** Open Translation Environment, Materials Ontology, Artificial Intelligence, Materials Modelling Solutions, Modelling Workflows, Open Simulation Platform, Materials and Process Design, Semantic Systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Sexual selection - How is variation maintained?'.

assistant: **Objectives**

Across the animal kingdom, striking displays and ornaments are produced by sexual selection. Current thinking is that females choose the most elaborate males because they display genetic benefits to offspring. However, this should lead to a rapid decline in genetic variation within species. Variation between individuals is the raw material upon which selection acts, so how is this variation maintained? Solving this ‘paradox of the lek’ continues to be one of the most contentious issues in evolutionary ecology.This proposal suggests that three important factors have been overlooked in the study of sexual selection. First, individual differences in mate preference function for direct verses indirect benefits are expected to vary with the choosers own phenotype, and thus serve to maintain variation within populations. Second, mutual mate choice has been neglected, and sex specific optima are expected to play a key role. Third, non-genetic parental effects are closely linked with mate preference and have huge implications for selection, but such effects are rarely considered in this context.I propose to test how these factors influence variation using an established population of wild great tits, which are amenable to carefully controlled lab and field experiments. I will complement phenotypic studies with state-of-the-art SNP genotyping and modeling techniques to determine how the heritability of shared traits and preference functions, and selection for heterozygosity affect genetic variation. This uniquely integrative approach will answer a fundamental question in evolutionary biology: How is genetic variation maintained by sexual selection? The answer to this question is key to our understanding of evolutionary processes, the likelihood of extinction and speciation, as w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of lipid nanoparticles based on solid matrix for Benznidazole oral delivery targeting to the lymphatic system to treat Chagas disease' (LYMPHVECs).

assistant: **Concept**

According to the WHO there are 8 million persons chronically infected by Chagas disease (CD) resulting in 12.000 reported deaths annually. CD is one of the most significant health problems of Latin America. However, nowadays it has been reported worldwide. Benznidazole (BZ) has been recently approved in US (30/08/2017) as the first option treatment for CD but can only administered for 14 days or less, while it is known that at least 2-3 months of treatment are required for full efficacy. This approval for short-term CD therapy is due to the severe side effects associated with extended use, which severely impacts the applicability of BZ as a universal CD treatment.Importantly, Trypanosoma cruzi (Tc) parasite reservoirs have been localized into the Lymphatic System (LS). Poor compound distribution into the LS could be the reason why extended BZ treatment is required and why reactivation of the parasites in the chronic stage is commonly found.Chagas infected people treated with BZ develop rashes, fever, nausea, headache, allergic dermatitis, digestive intolerance (anorexia), peripheral neuropathy and insomnia. These severe side effects limit its use and foster non-compliance. BZ formulations that reduce compound exposure in system circulation while facilitating distribution into the LS could reduce the efficacious dose (at present 5-7mg/kg/day), reduce side effects, and possibly contribute treatment shortening. This project will develop BZ formulations based on solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) to achieve these three goals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Scalable manufacturing of bio-inspired & bio-based Graphene Foam components of extreme performance' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Nature uses foam or sponge-like structures in various organisms for purposes like shock absorption, noise reduction, and vibration compensation in a remarkable example of evolutionary adaptation and functional design. On the other hand, many products still rely on non-sustainable materials of fossil-based origin, for example foams and elastomeric used for vibratory motion, sound, harshness, energy, and shock-impact absorption in industries such as automotive, aerospace and marine. Example of such Noise Vibration and Harshness (NVH) materials are rubber and engineering resins. Bio.3DGREEN develops and demonstrates a novel manufacturing approach for a cost-effective bio-inspired platform of bio-based components based on graphene foam (GF) to meet the industrial needs, i.e. vibration, sound and shock-impact absorption and durability in extreme conditions. Bio.3DGREEN democratizes graphene technology and enables the unscalable fabrication of graphene-based components of complex geometries to be demonstrated at TRL 6 through a high throughput, laser-based Additive Manufacturing (AM) procedure. The procedure is bio-inspired, mimicking structures such as the human bone, and is based solely on bio-based graphene system with vegetable oil as the raw material, resulting in carbon-positive manufacturing of the new components. Bio.3DGREEN demonstrates the superior bio-based GF parts in four different industries, aiming to drive the optimization of the new manufacturing approach through an application-driven approach: Automotive suspension systems & isolation panels, aerospace applications and quiet shipping. Bio.3DGREEN achieves a multi-disciplinary approach to develop, optimize, and improve smart manufacturing application-driven, bio-based GF components, also considering the perfo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EMBL Interdisciplinary Postdoc Programme 4' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

EIPOD4 is an international postdoctoral fellowship programme embedded in the world-class research environment of EMBL. It fosters interdisciplinary and intersectorial research opportunities between academia, industry, clinics and museums via three available tracks (Academic, Industry, Clinical). The programme will host 60 experienced researchers recruited in 3 globally advertised calls following a transparent and merit-based evaluation and selection process with international peer-review. Fellows receive 3-year employment contracts to complete their self-designed interdisciplinary research projects. They develop interdisciplinary research skills and complete a mandatory training portfolio targeting transferable skills.A dedicated career development service and career secondment opportunities allow EIPOD4 fellows to further develop core competencies and enhance their networking skills. They are part of EMBL’s established Second Mentor programme and develop their own mentoring skills via the new EIPODs Inspire scheme where they support junior colleagues from less-represented countries.The programme aims to educate future scientific leaders with a strong sense of their responsibility to society. An important aspect of this is to engage in dialogue with the general public. The project partner, the Natural History Museum in London, will provide fellows with science communication training. Fellows will also have the unique opportunity to participate in one of the museum’s high profile public engagement events.EIPOD4 supports the increasing diversity of career paths in Europe’s research landscape. The programme will increase the visibility of the European Research Area as an attractive destination for experienced researchers to receive valuable and innovative training. As many
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Science in Dialogue - Conference during the Danish EU presidency' (SID), addressing dissemination and exploitation.

assistant: **Impact**

The Danish EU presidency conference ’Science in Dialogue’ will bring together policy makers, research institutions, businesses, professional science communicators and NGOs to discuss and reflect on the relationship between science and society. The conference will take place in the city of Odense, Denmark, from April 23 to April 25 2012.A strenghtened dialogue and interaction between science and society is vital if science is to deliver on the solutions needed for addressing the major societal challenges. A mutual responsiveness between researchers, innovators and society at large must be an underlying mindset and precondition Horizon 2020 as well as for other future European frameworks.The overall objectives of the presidency conference are to: Offer a platform for stakeholders from Europe and abroad to discuss and reflect on the interaction and dialogue between science and society; Provide input on aspects of a European model for Responsible Research and Innovation (RRI); Provide input to future instruments for research funding; Promote a basis for the successful solution of the grand challenges in Horizon 2020.The conference will present high-level speakers and part of the programme will be dedicated to workshops based on participatory methodology during which the participants will be urged to exchange and discuss cases and best practices to the participants. The conference will thereby also seek to inspire and to support the formation of a European network on the subject matter.The conference will be organised  by the Danish Agency for Science, Technology and Innovation under the Danish Ministry for Science, Innovation and Higher Education.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Elaboration of the type I interferonopathies' (E-T1IFNs).

assistant: **Concept**

Type I interferons represent both key molecules in anti-viral defence and mediators of inflammatory disease, so that the induction, transmission and resolution of the interferon response are tightly regulated - balancing protection against infection versus the risk of immunopathology. Monogenic type I interferonopathies (T1IFNs), and related ‘complex’ phenotypes such as systemic lupus erythematosus and dermatomyositis, represent examples of a disturbance of the homeostatic control of this system, where a constitutive upregulation of type I interferon activity is considered directly relevant to pathology. Set against the absence of a routine assay in clinical medicine for the detection of upregulated type I interferon, the current application addresses major questions in the developing T1IFN field. Analogous to other screening strategies (e.g. using mouse ENU mutagenesis or yeast gene deletion series), we have established a pipeline for the systematic identification of human mutant states predisposing to upregulated type I interferon signalling. Such an approach will allow for the comprehensive definition of important themes in interferon biology, informing our understanding of anti-viral signalling and self-non-self discrimination. Furthermore, these studies will have direct translational benefit - since the identification of a phenotype as a T1IFN implies the possibility of therapy to reduce type I interferon levels and / or block interferon signalling.


**Keywords:** Type I interferon, type I interferonopathies, innate immunity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biomimicry and carbon adsorbent eco-materials for a climate-neutral economy' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The European Commission (EC) launched the New European Bauhaus initiative to improve the well-being and health of citizens and future generations. The initiative is an environmental, economic, and cultural project aiming to combine design, sustainability, accessibility, affordability, and investment with helping deliver the European Green Deal. It aims at sustainable solutions that create a dialogue between our built environment and the planet’s ecosystems. CSTO2NE aims to provide the European community with innovative solutions for recycling and valorising biowaste (biomass) and industrial waste into new eco-engineered materials through industrial symbiosis waste co-utilisation, mineral carbonation, and biomimicry approach; namely, nature-inspired solutions and technologies for improving carbon uptake and waste incorporation and design eco-engineered materials and, transference of the emergent technologies through eco-innovation business models. In this context, CSTO2NE intends to (1) promote international and inter-disciplinary collaboration through research and innovation staff exchanges, leading to extended networks and opportunities; (2) Enhanced networking and communication capacities with scientific peers, as well as with the general public that will increase the project’s impact, (3) foster a shared culture of open access research an co-creation, that welcomes and rewards creativity and entrepreneurship, inspired by the New European Bauhaus concept, fostering ideas into innovative prototypes and technologies for the eco-materials circular economy.


**Keywords:** Carbon capture and utilization, Mineral carbonation, Carbonated Materials, Business Innovation Models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Exploring the contribution of bacteriophages to the emergence and spread of antibiotic resistance in environmental settings' to be submitted under Horizon 2020.

assistant: **Abstract**

Antibiotic resistance has become a global public health concern. Although this phenomenon has been widely studied in clinical settings, its impact has not been extensively explored in environmental settings. The environment is continually exposed to a wide variety of antimicrobials and their metabolites through wastewater treatment plant discharges, agricultural runoff, and animal feeding operations which may contribute to the emergence and spread of antibiotic resistance. Moreover, the large-scale mixing of environmental bacteria with exogenous bacteria from anthropogenic sources provides the ideal selective and ecological conditions for the emergence of resistant bacteria. As a consequence, aquatic environments may provide ideal settings for the horizontal exchange of antibiotic resistance genes. Our working hypothesis is that bacteriophages (phages) play an important (and overlooked) role in the acquisition, maintenance and spread of antibiotic resistance genes (ARGs) in environmental settings, particularly under anthropogenic disturbances. The specific aims of the ENVIROSTOME project are (i) to determine the contribution of phages to the horizontal transfer of ARGs in aquatic environments, and (ii) to investigate the impact of conventional and novel disinfection approaches in wastewater treatment on the prevalence of ARG-carrying phages in aquatic environments. Dr. Balcazár’s group have demonstrated that environmental phages contain a large diversity of ARGs, which warrants further research to clarify their contribution to the emergence of antibiotic resistance among environmental bacteria, as well as to investigate their control through disinfection. The results of this research are expected to deliver critical insights for tackling the global crisis of antibiotic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'COSY - Density-dependence in cockle populations: possibilities for a sustainable fishery' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This project will contribute to our understanding of the role density-depending processes in the dynamic of an exploited bivalve species ( Cerastpderma edle ) from natural beds in the Wadden Sea and the Oosterschelde estuary.By using an innovative modelling approach the B-N diagram, some specific issues will be addressed to identify the relevant spatial scale(s) at which density dependence occur and may affect population dynamics of C. edule: possible occurrence of density-dependant mortality in cockle populations: the factors responsible for density-dependant growth and or survival in cockles i.e competition for space or trophic resources: and finally possible impacts in terms of Economy i.e. sustainability and profitability of the cockles fisheries and of ecology, i.e. protection of estuarine habitants including food reservation for wading birds.