RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Chemical biology of natural products in plant-bacteria interactions' (CHEMBIOLPBINT) under Seventh Framework.

assistant: **Objectives**

This project deals with the elucidation of the biological role of natural products in plant-bacteria interactions. Plant-associated bacteria synthesize a vast number of biologically active natural products that modulate the physiology and functioning of their host plants. For example, plant pathogens often cause devastating crop losses by secreting low molecular weightphytotoxins, while some symbiotic bacteria biosynthesize plant-protecting compounds that assist in lowering biotic and abiotic plant stresses. It is therefore surprising that although natural products seem to play key roles in the complex interaction network between bacteria and plants, most of their biological functions and molecular targets are still unknown.To date, almost all studies on plant-bacteria interactions have been performed with  biological  approaches. Here, we propose to investigate the biological role of plant-associated natural products with the aid of a chemistry-driven approach, relying on the power of chemical synthesis to i) generate these natural products and/or suitable natural product derivatives, ii) to elucidate their targets in plants, and iii) to apply them in plant-bacteria studies. Although natural products have long been in the focus of chemical research, such a systematic chemistry-driven approach has, to our knowledge, never been performed before in plant-bacteria interactions. Our project will therefore not only serve to i) decipher basic research questions and ii) identify potential lead structures for agricultural and medicinal applications, but will also contribute to iii) the refinement of chemical syntheses strategies, iv) the advancement of target finding approaches and v) the establishment of chemical biology approaches in plant biology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Optimised packing in cement based products using by-product fines', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The European concrete industry is large and in constant need for innovation and development. Practical concrete manufacturing recommends the use of dust free aggregate, but recent particle packing models provide theoretical justification for using very fine grained material. Particle packing models have not been utilised in standard concrete technology, thus incorporation of by product fine material (BPF) has been sporadic and has lead to inconsistent results. BPF is currently considered a waste material and causes additional disposal costs. The research goals are to develop an empirically verified mix design method based on particle packing models for BPF incorporation, which will increase BPF use in cementitious products. The effects of BPF on the basic properties of building application products will be determined, as well as improving economical and ecological impacts. The research methodology will be a combination of desk studies, laboratory analysis, field/insitu investigations and pilot testing. The research is divided into the following sequential parts: Baseline report > By product fines (BPF) identification and evaluation > Production of cementitious materials containing BPF > BPF product application properties The project benefits are associated with the promotion of BPF use: lowering the cement consumed by 10 %, reducing CO2 released by 1 million tons per year, and lowering the overall cementitious product prices. At the same time the product quality will be improved. An additional advantage is the technology for using the accumulated BPF within the European stone/concrete industry. The project is within the scope and objectives of the programme Industrial & Materials Technologies" in Area 1:"Production technologies" under 1.2 ' Development of clean producti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Bioflavonoïds and polyphenols in health and disease' in the context of a Fifth Framework call.

assistant: **Objectives**

The subject of the meeting is in relation with the quality of live and management of living resources: food, nutrition and health, this meeting deals with the role of bioflavonoïds and polyphenols contained in foods (vegetable, fruits) and beverages (Wine Tea Cider in the prevention of disease such as vascular disease neurological disorders and aging (Alzheimer's disease, parkinson's disease), cancer. Different items will be developed: natural sources and bioavailability of polyphenols, chemical and biochemical reactions cell regulation and disease epidemiological evidence of health effects. The best specialists in this research area are invited. The meeting received the agreement of SFRR European committee to be the annual meeting of the SFRR European Region. (SFRR: Society for free Radical Research). The objective of this meeting is to better understand which benefit for health people would obtain by consuming polyphenols in diet (vegetable, fruit, wine, tea).The role of these compounds is still controversial and scientific evidence are required to establish nutritional recommendation in order to prevent diseases such as cancer, cadiovascular disease and neurovegetative disorders. In relation with aging; one of the major problems for food nutrients such as polyphenols is their absorption and bioavailability. Numerous studies are carried out to determine the molecular and cellular role on polyphenols as natural antioxydants. Epidemiological studies on polyphenol consumption and health effects suggest that high amount of polyphenols in the diet may lower the mortality from coronary heart disease although many data are still controvertial. This meeting will contribute on advances in the field of quality of life in relation with nutritional aspects. This meeting will cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Network for the Study of Adrenal Tumours - Structuring clinical research on adrenal cancers in adults' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Among patients with adrenal masses Adrenocortical carcinoma (ACC) and malignant pheochromocytomas (MPH) are found with a low incidence but very unfavorable prognosis. Due to this poor clinical outcome, concomitant hormone dysregulation and limited treatment options the two cancer entities severely impact on affected patients. However, the rarity of the tumors also impedes clinical studies which are affected by fragmentation and low cohort sizes.The European Network for the Study of Adrenal Tumors (ENS@T) has recently implemented a collection of adrenal tumor related databases and defined an associated network of Biological Resource Centers devoted to research on adrenal tumors. The concurrence of recent achievements of this evolving network, the progress in the understanding of molecular mechanisms and increasing availability of specific diagnostic and therapeutic tools for adrenal cancers provides the unique opportunity to achieve unmatched progress in the implementation of both translation and clinical research dedicated to ACC and MPH. Specifically, the newly formed ENS@T-CANCER consortium will address the following topics: 1. Structuring European clinical and translational research through implementation of a virtual research environment, 2. Improving clinical outcome of patients with adrenal cancer by conducting interventional trials carried out by European centers of excellence, 3. Improvement of differential diagnosis and risk stratification of adrenal cancer, 4. Identification and validation of tools for follow-up of patients with adrenal cancer, 5. Identification of novel biomarkers for treatment response.The ultimate aim of the ENS@T-CANCER Consortium is to develop research in the field of adrenal cancers to improve diagnosis and treatment abilities. The Netwo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Investigating Virus-Host Interplay in Human Primary Models of Genetically Modified Respiratory Epithelium'.

assistant: **Innovation**

Respiratory viruses can rapidly spread worldwide with a devastating impact, as dramatically highlighted by the COVID-19 pandemic. In addition to the pandemic threat posed by influenza A viruses (IAV) or coronaviruses, respiratory viruses, including IAV, influenza B virus (IBV), seasonal coronaviruses and respiratory syncytial virus (RSV), are the cause of yearly epidemics, with a huge impact on human health. The vast majority of in vitro studies has been performed with model cancer cell lines. However, they share limited features with the primary cells found within the human respiratory epithelium. Robust and relevant, ex vivo models of human primary airway epithelia, cultured at the air-liquid interface (ALI) have been developed over the years and nicely recapitulate the structure and composition of the in vivo respiratory epithelium. Nevertheless, in depth studies on the genes and the potent innate immune, interferon (IFN)-induced, defences regulating viral replication in such pertinent models are still lacking. The InVIRium project will address this knowledge gap by combining a newly acquired expertise in the generation and gene editing of human ALI airway epithelia, with a strong expertise in CRISPR screens and virology. The objectives of InVIRium will be to explore in depth the relationships between major human respiratory viruses, SARS-CoV-2, IAV, IBV and RSV, and their relevant, primary target cells. InVIRium will characterize the IFN-stimulated-genes responsible for the potent antiviral state, explore the mechanisms of SARS-CoV-2 escape from the IFN system and define the landscape of host genes regulating respiratory virus infection in this physiologically relevant ALI model. InVIRium will bring a change of paradigm in the way we study respiratory viruses, by im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Spatiotemporal Analytical Modelling for Paleobiology' (STAMP) targeting Horizon Europe.

assistant: **Abstract**

Radical changes in the Earth’s biome as a consequence of climate change will fundamentally affect human society and its relation to the natural world.  How can we best model species dynamics, to make predictions for the future? What are the main drivers underlying these dynamics, and how are these changing as we enter the Anthropocene? A great compass for biotic changes we will see in coming decades is the study of changes the Earth has experienced before – from alterations in the distribution of terrestrial and marine mammals, to the dynamic changes in the range and connectivity of forests. There is now a wealth of historic and prehistoric records documenting these processes, including pollen and fossil records, ancient genomes and sedimentary DNA. Here, I propose a research programme called Spatiotemporal Analytical Modelling for Paleobiology (STAMP) to link these disparate types of paleobiological records with the methodological tools of spatiotemporal process analysis. I will focus on three empirical research areas: 1) reconstruction of megafauna species ranges across the late Pleistocene and Holocene; 2) reconstruction of boreal paleo-forest dynamics; 3) study of the historical resilience and mobility of arctic marine mammals. These empirical projects will be supported by two computational approaches to inference: one based on descriptive spatiotemporal modelling, and another based on dynamic simulation-based inference. STAMP will produce a new conceptual paradigm for thinking about paleobiological data and create a statistical methodology that will be widely applicable to palaeontologists, geneticists, paleo-botanists and ecologists worldwide. Ultimately, it will empower the next generation of paleo-scientists with powerful tools to use the living past as a spatia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'LEARNING TECHNOLOGY ACCELERATOR' under Horizon 2020.

assistant: **Concept**

Based upon the finding from IMAILE PCP of Innovative STEM/PLE (www.imaile.eu), the project LEARNTECH ACCELERATOR ( LEA)  will take a quantum leap from being one standalone project to  critical mass of European procurers  who will:1. Unify LEA procurers network and ""Observer Cities ""2. Implement  IMAILE PCP lessons learned as LEA baseline 3. Recommend a LEARNTECH Demand policy - 2030 to reduce fragmentation of  the  public sector 4. Enable increased dialogue between demand/ supply side 5. Provide transfer of knowledge for the LEARNTECH community ( other procurers, industry, start-ups , end - users and policy level) in order to remove barriers of innovative procurement 6. Prepare one PPI ( based upon IMAILE) and one additional future PCP 7. Speed up awareness rising  of innovative procurement including cross sectorial value chains LEA WP- METHODOLOGY  is developed in order to achieve the above mentioned objectives and with focus to  ""ACCELERATE"": - LEA network collaboration ( WP 2) - Demand  policy recommendations ( WP 3)  - Dialogue tools/ venues between demand & supply side  ( WP 4) - Knowledge transfer within the community ( WP5) - Awareness rising on EU level ( WP 6)  This unified and knowledge based  action will result in the  LEA ROADMAP  2030 including: -Critical mass of European procurers of LEARNTECH in collaboration acting first customers -User cases for evidence of cost& time saving/ standardization/ interoperability as results of innovative procurement -2030 LEARNTECH market foresight and demand policy -Training material/methods/tools for increased competence and dynamic dialogue among LEARNTECH community  -One prepared PPI absed upon IMAILE with lessons learned - One addtional prepared PCP identified in LEA Implementation of the LEA project  shall contrib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of a low cost, low power consumption system for manufacturing ozonised fluid ice for fishing, via an absorption system' in the context of a Sixth Framework call.

assistant: **Objectives**

The research work proposed in the project will aim at developing a low cost ice generating system, which will require low energy consumption for its running and which will be more reduced in size, thus more suited to the needs of small and medium sized f ishing vessels: The energy required for the system will be obtained by taking advantage of the heat off the engine via an absorption process. By using such a system it is possible to recover and reuse the thermal energy which is emitted into the atmosph ere to produce ice, thus avoiding the consumption of fuel. In order to generate ice, seawater which has been previously ozonised, will be used thus favouring the conservation of the fish. The ozone is generated on board via an electrochemical process.  The system will generate liquid ice. Compared with other ice production systems, the machinery in this system will be of a reduced size and will have a lower product ion and installation cost. The ice will have a greater thermal transfer, will not har m or damage the skin of the fish, will be transportable via pipes, can be and stored in tanks. A prototype system will be built and validated in a real environment and tested out at sea in order to monitor and improve it performance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovative high-sensitivity avalanche field-effect transistors designed for cancer diagnosis' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The focus of the HSAFE project, which aligns with the specific objectives of the Marie Curie SE-2024 call, is to develop an ultrasensitive diagnostic tool necessary for the identification and detection of lung and lymphoma cancer cells at an earlier stage of development. Early detection significantly increases the chances of a complete cure for the patient. The project proposes to produce a new biosensor based on an avalanche FET array and innovative 2D materials to overcome some disadvantages of traditional cancer detection methods, such as being time-consuming, expensive, and lacking in sensitivity and specificity. The successful implementation of the project will be ensured by sharing the experience and knowledge gained in the fields of physics, technology, and engineering in a coordinated manner. Strengthening modern knowledge in the field of sensors and applying modern technological approaches and methods will be achieved through the international cooperation of highly qualified scientists and engineers from Azerbaijan, the Czech Republic, Hungary, Portugal, Poland, Turkey, and Ukraine. This consortium will address both technological (e.g., micro-sized sensor design, biosensor reader production) and fundamental (e.g., innovative material synthesis, internal avalanche amplification mechanisms of ultra-weak signals, biomarker immobilization process) issues.


**Keywords:** Field-effect transistor-based biosensors, Cancer diagnostic, diagnostic tools, and public health
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'RESPILIQ - enteral CO2 absorption for the therapy of hypercapnic lung failure' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Premature babies and patients with acute lung failure in the intensive care unit or COPD patients at home: they all suffer from the same potentially fatal condition: hypercapnia = an increased level of CO2 in the blood. In Europe alone there are around 1.8M people. Hypercapnia is one of the major challenges in the therapy of acute lung failure and long-term weaning in ICU and in the outpatient treatment of COPD, which has not yet been adequately solved. Our goal is to revolutionize therapy and significantly improve survival and, above all, the quality of life of these large patient groups suffering from hypercapnia. Instead of tackling the problem via the lungs, RESPILIQ uses the human gut as a respiratory organ. The intestine forms a highly effective exchange membrane for carbon dioxide (CO2). In the gut, RESPILIQ can bind CO2 from the intestinal fluid and excrete it via naturalis. Administered orally or rectally, RESPILIQ initiates a life-saving reduction of pCO2 in the blood


**Keywords:** Hypercapnia, acute lung failure, COPD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Demographic consequences of humanitarian crises in Latin America'.

assistant: **Concept**

Latin American countries are vulnerable to a range of natural hazards; to political and economic crises; and to armed conflicts. Since 1994, the European Commission has provided over €1 billion in assistance to Latin American countries facing humanitarian crisis. However, little is known about the demographic impacts of those crises and the humanitarian aid outreach. The reason could be attributable to the lack of good quality in regional official data. Inadequate estimates have implications on the attention that a humanitarian crisis receives, as policy makers need to be aware of the sensitivity of changes in accurate figures and rates. The main objective of this project is to produce accurate demographic estimates that enlighten our understanding of the complex dimensions of a humanitarian crisis in Latin America, using Venezuela as an example. Venezuela is currently undergoing a profound social and economic crisis with far-reaching consequences for its demographic trends. As migration became the only survival strategy possible for most Venezuelans, the crisis has been spilling over the continent, leaving no country in Latin America unaffected. Studies on the demographic consequences of a catastrophe usually refer to events in the distance past, in this regard; the main innovations of this project is to produce accurate updated estimates for keeping track of the demographic consequence of an ongoing crisis. To achieve this, I will (1) apply advanced statistical techniques and demographic (in)direct methods to ensure high-quality and updated demographic estimates of an ongoing crisis; (2) forecast demographic responses to the crisis in order to shed light on public policy design and on humanitarian aid preparedness plans; and (3) use a cross-country comparison and regi