RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Higher education reform network: a collaborative partnership to explore, disseminate and advise on the university of tomorrow - in relation to societal change and lifelong learning needs and in the context of european enlargement' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The proposal aims to provide policy developers with a better understanding of the relationship between tomorrow's university and societal changes across Europe in the lead up to EU enlargement. It argues that HE needs to be responsive to, as well as stimulate, new perspectives for learning in this context. It analyses past and presents social trends, structural changes influencing HE in each country, values underlying evolving strategies and the extent to which HEIs perceive their social responsibilities towards Europe. The network explores these questions through an innovative matrix of domains. (Society, governance, teaching and learning and change); strategies: (for inclusion, a regional role and employability) and concepts: (of citizenship, EU integration, lifelong learning and technology as a means to learn). The network's core activities will be a term seminar series, interactive website and database resulting in policy briefing papers and new research collaborations. Membership of the network consists of international consultants, researchers, policy leaders and practitioners with involvement in extensive dissemination infrastructures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Performance of reference methods and validation on commonly used methods in E.U. for the enumeration of E. coli and enterococci in bathing waters'.

assistant: **Innovation**

The project intends to make available standard protocols for: - Reference methods for the enumeration of E. coli and enterococci that can be used for the determination of the microbiological quality of bathing waters (fresh and sea). - The determination of the performance characteristics of these reference methods, using artificially and naturally contaminated bathing waters. - The validation of some commonly used official methods in comparison with reference methods, in diverse situations as encountered in the E.U. To reach these general objectives we propose the following steps: - Development of reference methods, reference materials and standard protocols for the evaluation and the validation of microbiological analytical methods. - Training ca 20 participants with the reference methods and the reference materials, and validation of the standard protocols ' through sessions in a central laboratory. - Implementation of the standard protocols in a number of laboratories of the E.U. in order to determine the reproducibility of the reference methods and to test some commonly used official methods in the field conditions in comparison with the reference methods in various bathing waters representing, as far as possible, all different bathing water typologies in E.U. This objective will be reached through interlaboratory studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Waveguide-type semiconductor integrated circuits (ICs) in gaps between conducting surfaces with texture – architecture, electromagnetic modeling and micromachining' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

In order to explore and exploit the frequency range from 30 GHz up to THz, new types of transmission lines and semiconductor architectures are needed. Conventional microwave technologies that are commonly used below 30 GHz become either too lossy or are too expensive to manufacture, and technologies used in the optical regime are not usable either. The intermediate frequency band is therefore often referred to as the THz gap, indicating the lack of commercialize-able technologies there.Professor Kildal has invented a fundamentally new regime of transmission line, referred to as gap waveguides. The basis is newly discovered local waves appearing in the gap between two conducting surfaces, controlled by a texture in one or both of the surfaces. The gap waveguide has been verified below 20 GHz, but it will be more advantageous in the THz gap. The texture will for THz applications be of submillimeter or micrometer scale, realizable by micromachining or etching. Also, there is no need for a dielectric substrate, and there is no need for conductive contact between the two surfaces. Therefore, such gap waveguides and circuits for the THz gap can be manufactured with low cost.The vision is that the topology of this new regime of gap waveguides will facilitate integration of semiconductor devices, and may lay the foundation for new architectures of transistors and other integrated circuits, being located inside the gap encapsulated by the conductive surfaces themselves. In order to reach this vision new and efficient numerical electromagnetic methods and modeling tools need to be developed, taking advantage of the particular gap waveguide geometry, and being able to connect to or replace the charge transport models for the transistors in the doped semiconductors themselves.The g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'From photons to storms: Revealing the 3D structure of giant exoplanet atmospheres'.

assistant: **Objectives**

The solar system's giant planets, Jupiter and Saturn, host atmospheres with clear belts, cloudy bands, and storms like the Great Red Spot. They represent the class of cool, isolated giant planets. For a full view of giant planet atmospheres we must study the known exoplanet population over a wide range of orbits, temperatures, and spins. However, exoplanets are too far away to resolve them directly.The James Webb Space Telescope is changing this: time-resolved spectra probe the atmospheres of rotating wide-orbit planets, whose light curves reveal active weather. The Extremely Large Telescope's METIS and ANDES instruments will study giant planets from close to wide orbits at high spectral resolution, probing winds through Doppler shifts, allowing us to constrain flow and temperature structures.In spite of these amazing prospects, there is no framework to properly fit JWST or future ELT data. State-of-the-art techniques are prohibitively slow, preventing hypothesis testing. This is a fundamental challenge that needs to be resolved - otherwise we cannot use the information encoded in our data.With the VORTEX project I will develop the machinery to map the 3D, dynamical atmospheres of giant exoplanets, from strongly irradiated to the most isolated ones. The modeling challenge will be addressed through a feedback between novel machine learning inference methods and hydrodynamical models. Our project will answer the three questions: (i) what are the properties, scales and lifetimes of storms on isolated planets? (ii) how do flows transport gas on irradiated planets? (iii) how do atmospheres of planets on eccentric orbits react to changing irradiation?VORTEX will have a long-lasting impact by enabling the 3D interpretation of exoplanet spectra. Answers to the questions above w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Global regulation in Mycobacterium: Role of Lsr2', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This proposal aims at understanding the role of Lsr2 in the global regulation of the mycobacterial cell wall homeostasis, a critical attribute of their virulence. Mycobacteria are Gram-positive bacteria that are involved in a number of human (tuberculosis, leprosy, Buruli ulcer) and animal diseases (Johne’s disease in ruminanst, fish tuberculosis in aquaculture), in both developing and developed countries. The lsr2 gene in conserved in all mycobacteria sequenced thus far and recent data indicates that the Lsr2 protein might be a global regulator. Its function will be studied through various methods that involve transcriptome analysis, molecular genetic experiments (qRT-PCR, use of reporter gene, gel-shift) as well as genomics. The success of the research proposal will be achieved through several national and international collaborations. This program will be realized on the Necker campus of the University Paris-Descartes, a multi-nationality centre that has a long tradition in hosting visiting scientist. The present MYCO-REG proposal, which does not include any sensitive ethical issues, will help in consolidating the pre existing links with the Bose Institute, one of the best institutes in Life Sciences in India, where the applicant has been trained. This proposal will help the hosting team in developing an innovative project by attracting a young talented researcher and thus will serve in promoting the transfer of knowledge in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deciphering the role of microbiome-fibroblast crosstalk in intestinal immune development, homeostasis and inflammation' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The microbiome plays an essential role in intestinal immune development, homeostasis and inflammatory bowel diseases (IBD), however, our understanding of the underlying mechanisms by which it regulates these processes remains incomplete. Intestinal fibroblasts (iFB) are a heterogeneous population of tissue-resident cells increasingly recognized for their role in immune regulation. In preliminary studies, the host group and a collaborator found that human and mouse iFB express distinct arrays of microbial sensors and immune mediators and that iFB transcription is altered in germ-free mice. In my proposed project, I will combine state-of-the-art high dimensional flow cytometry, single cell (sc)RNA-seq, CITE-seq, spatial transcriptomics and bioinformatics analysis with animal models and analysis of human intestinal datasets to test the hypothesis that microbiome-iFB crosstalk plays a key role in intestinal immune system development, homeostasis and inflammation. Microbiome impact on iFB and intestinal immune system development will be assessed throughout the weaning period by treating mice with broad-spectrum antibiotics and/or antifungals. The importance of direct iFB-microbiome sensing for immune homeostasis and inflammation will be assessed as above as well as in dextran sulphate sodium (DSS)-induced colitis model in mice whose FB are deficient in either the Toll-like receptor signaling adaptor Myd88 or the C-type lectin receptor-Syk mediated antifungal response adaptor CARD9. Finally, translational aspects will be assessed through extensive bioinformatics analysis of iFB scRNA-seq datasets to map microbial sensor expression in human iFB subsets, evidence of downstream signaling through such sensors and their alterations in IBD. Collectively, this project uses a multi-s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'The learning region - innovation strategies in the Ruhr'.

assistant: **Objectives**

The project will evaluate the Ruhr's innovation strategies and draw on the concept of a 'learning region' (Lundvall, 1994), characterised by: * a clear orientation towards competing on the basis of change; * intense intra-regional input-output linkages; * a regional labour market for exchanging know-how; * regional conventions (shared norms and values) which provide stability (storper, 1994) * efficient information flows. The study aims to illuminate the extent to which policy in the Ruhr increases firms' capacity to use change productively. It focuses on the regional level because the increasing importance of knowledge in today's economy has strengthened the role of social and territorial factors in the economic process. The researcher should benefit from working with experienced researchers and drawing on the expertise of the host institution in this field. The methodology comprises interviews with key actors and a survey of companies in mechanical / plant engineering and new growth sectors. (For references, please see detailed proposal.)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Defining the molecular mechanisms of fibroblast-mediated inflammation and its role in cancer progression and metastasis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Breast cancer is one of the leading causes of cancer related mortality in women in the western world and inflammation is correlated with bad prognosis in breast cancer. Breast tumors are characterized by an extensive desmoplastic stroma, abundantly populated by fibroblasts. Cancer Associated Fibroblasts (CAFs) have been shown to promote the growth of mammary tumors by directly stimulating tumor cell proliferation and by enhancing angiogenesis, but their role in mediating inflammation in breast tumorigenesis is unknown. Despite the fact that most of cancer-related mortality is a result of tumor metastasis, and not of the primary tumor, very little is known to date about the role of the metastatic stroma in allowing disseminated tumor cells from the primary tumor to propagate and colonize the metastatic organ. Even less is known about the role of fibroblasts in this critical stage of the metastatic cascade. Using a genetically engineered mouse model of mammary carcinoma we will investigate pro-inflammatory signaling by CAFs during different stages of mammary tumorigenesis, starting at early hyperplastic lesions, elucidate its functional importance and define the molecular pathways that underlie inflammatory signaling by mammary CAFs in tumor progression and metastasis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Insights into the ecophysiological and molecular significance of xylem hydraulic capacitance in Populus under drought stress' (2007-2013).

assistant: **Concept**

Global change is expected to amplify the frequency and the severity of heatwaves and drought events especially in Western Europe. These droughts jeopardize tree health and integrity of European temperate forests and tied ecosystems. There is a need to identify the processes that may allow trees to overcome severe water scarcities. Tolerance to xylem embolism is an intrinsic and operational trait related to tree drought resistance. Moreover, ecophysiological studies have pointed to the existence of hydraulic capacitance connected to embolism as a preventive way out against moderate desiccation avoidances and buffering water potential fluctuations. This capacitance influence is expected to be ensured by living xylem elements (capacitors). However, capacitance is paradoxically a rare physiological event underlined, as the physical and genetic basis of capacitance remain totally unresolved.Here the aim of the project is to define the “hydraulic capacity” of xylem capacitor elements under quantified changes in xylem water tension state, and to identify a class of genes placed alongside physiological and biochemical measurements that will highlight the functioning of these capacitors. To achieve this task, our strategy will be first to identify the key ecophysiological features of xylem capacitance and secondly, we will undertake a molecular study to correlate the potential involvement of genes (WAK and MIP) coding for this process. Lastly, we will perform the functional validation of related proteins of interest by biochemical and bioinformatic approaches.This tree hydraulic capacitance project fits perfectly into the framework of Marie Curie Actions, spanning the “Environmental and Geo-Sciences” and “Life Sciences” themes. As the underlying nature involving drought adaptive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Earthquake engineering research centre' in the context of a Fifth Framework call.

assistant: **Objectives**

The Installation consists of a 3 x 3m, 6-axis shaking table and ancillary facilities for experimental studies in earthquake engineering and structural dynamics. The operating range is 0-100 Hz and the maximum payload is 15 tonnes. The recently upgraded control system allows high- fidelity input signals to be applied to the test-piece, its active feedback control in real-time allowing studies to be made of non-linear behaviour.Application:Access is offered under the contract to researchers from Member and Associated States who wish to familiarise themselves with advanced experimental techniques. The Bristol shaking table joins with 3 other similar European facilities in offering access to shaking tables and a reaction-wall. A cost of living allowance is paid in addition to the free access. A call for proposals appears every 6 months in the Journal for Earthquake Engineering and structural.Project Manager:Roy Severn, Civil Engineering - Earthquake Engineering Research Centre (EERC), Queen's Building, University Walk, Bristol BS8 1TR, United KingdomTel: +44-117-9287708Fax: +44-117-9287783E-Mail: R.T.Severn@bristol.ac.uk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Unraveling the molecular mechanisms involved in the regulation of iron-mobilizing coumarins biosynthesis, trafficking and secretion' to be submitted under Horizon Europe.

assistant: **Abstract**

Iron (Fe) is an essential micronutrient for the productivity of crops and the quality of their derived products. Fe is also the most deficient mineral nutrient in human diet. Decrypting the molecular mechanisms plants have evolved to acquire Fe from the soil is essential for improving their capacity to absorb and store Fe, which will help to provide adequate dietary Fe to the growing global population. The secretion in the soil of root-borne coumarins has emerged as a key factor affecting Fe uptake in non-grass species. The mechanisms by which Fe mobilizing coumarins biosynthesis, trafficking and secretion is regulated is still not well understood. Using an original bioinformatic pipeline, the candidate has identified conserved DNA-signatures in the promoter of key genes involved in this process in different plants species, including crops. The objective of this project is to identify and characterized in Arabidopsis the regulatory proteins associated with these DNA-signatures and determine their role in plant Fe nutrition. In work package 1 (WP1), the developed bioinformatic pipeline will be further used to enhance the detection accuracy of conserved potential regulatory DNA motifs present in the promoter of Fe-mobilizing coumarin genes. Candidate proteins interacting with the selected potential DNA motifs will be identified using in silico and in vivo approaches (WP2). Last, we will generate mutants in order to precisely define the role of each candidate identified. In vivo imaging of coumarin and candidate protein localization will be conducted to ascertain the role of each candidate in the spatiotemporal distribution of coumarins within the roots (WP3). The proposed project is both feasible and appropriate for a Marie Skodowska-Curie Individual Fellowship, since the