RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Vascular determinants of cancer cell fate and immune regulation in brain metastasis', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Brain metastasis (BrM) is one of the deadliest cancer complications, affecting 30-40% of patients. When cancer cells migrate from the primary tumor to the brain, they face the critical challenge of adapting to an entirely new microenvironment. This includes various tissue-resident cell types, a distinct extracellular matrix composition, and more importantly, the challenge of traversing the multiple layers constituting the blood-brain barrier (BBB). The BBB – composed of the endothelial cells, mural cells, and associated microglia and neurons – not only serves as the initial gateway for cancer cells during the early stages of metastatic colonization but also for recruited immune cells, such as cytotoxic T cells, in advanced stages of the disease. The METAVASC project pioneers a novel study of the brain vasculature as a key regulator of both early and advanced stages in BrM, challenging the traditional view of the vascular system as merely structural. By following a multifaceted approach – including niche labeling systems, CRISPR and drug screenings, multiplex immunofluorescence, spatial transcriptomics, and functional studies – this project aims to overcome current limitations in understanding BrM biology from a vascular perspective, addressing two key questions: How do vascular components influence cancer cell survival during the initial stages of BrM (Aim 1)? And how does the brain vasculature regulate immune cell recruitment and activation in later stages (Aim 2)? Although immunocompetent BrM mouse models will be critical to address most of the fundamental questions in this project, the validation process in human samples represents an important milestone (Aim 3), as our ultimate goal is to translate our findings into tangible benefits for patients. In METAVASC, we ai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Inactivation of the excitatory neurotransmitter glutamate. Its role in acute and chronic neurodegeneration'.

assistant: **Innovation**

Acute brain diseases like stroke and ischemia (as seen in cardiac arrest) as well as chronic degenerative brain disorders like epilepsy, Alzheimer's disease and Huntington's disease have immense consequences both socioeconomically and individually. It has been suggested that these diseases are linked to abnormal extracellular concentrations of the excitatory neurotransmitter glutamate in the brain. It is of vital importance to establish whether this is true or not to pave the way for pharmaceutical research aimed at rescuing brain cells at risk of degeneration. Inactivation of glutamate is achieved by uptake into nerve cells or glia. The project will use molecular biological techniques (gene targeting) to develop mice without neuronal or glial uptake mechanisms to study the importance of such uptake mechanisms for the survival of nerve cells in animal models of stroke, epilepsy and chronic neurodegeneration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Remotely sensed biogeochemical cycles in the ocean' to be submitted under Seventh Framework.

assistant: **Abstract**

In the context of global change and ocean response to climatic and anthropogenic forcing, it is critical to improve our understanding of biologically mediated carbon fluxes and to reduce the uncertainties in their estimates. At the root of much of the present uncertainty in carbon budget is the scarcity of data. Based on state-of-the-art remotely-operated techniques of observation (profiling floats and satellite) and bio-optical modelling, REMOCEAN aims at addressing the causes of variability in the so-called biological oceanic pump in key oceanic areas: (1) the North Atlantic (especially Labrador Sea, Irminger Sea, Iceland basin), which despite representing only 1.4% of the ocean s area, accounts for about 20% of the global ocean carbon sink; (2) the sub-tropical gyres of the Atlantic and Pacific for which, although they represent ~ 60% of the ocean surface, the contribution to oceanic carbon cycle is still a matter of debate. The scientific objectives of REMOCEAN will be implemented along four main activities.  Development of profiling floats to measure oceanic variables essential for the characterization of phytoplankton dynamics and related carbon fluxes. " Deployment of these floats in the four sub-tropical gyres of the Pacific and Atlantic Oceans and in the North Atlantic to conduct a totally automated investigation of biogeochemical cycles in these areas over a continuum of temporal scale and over a period of 3-4 years. " Development of parameterisations linking surface biogeochemical properties to their vertical distribution in the ocean interior, and ultimately development of 3D fields of these properties by combining float and satellite data. " Estimation of carbon fluxes by combining these fields with bio-optical modelling including retrospective analyses tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Complex Oscillatory Systems: Modeling and Analysis' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Many natural and artificial systems are often composed of oscillatory elements which, besides evolving according to their own non-trivial internal dynamics, mutually interact. As a result, many temporal and spatial scales are typically present, often accompanied by the spontaneous emergence of collective properties. Altogether, such features make the task of understanding the resulting evolution a challenging interdisciplinary problem. Zero-knowledge methods do generally require too large amount of data to allow drawing meaningful conclusions. In order to overcome this limitation, it is necessary to add skilful hypotheses about the structure of the underlying model and, thereby, on the relevant variables. This task is often tackled in an ad hoc way and the approach is based rather on personal preferences than on objective elements. The goal of this project is to fill the gap, by developing a general and coherent set of tools for the system identification and control, as well as to improve our ability to make predictions. The task will be pursued by combining top-down with bottom-up approaches which will be used to identify the most appropriate variables. Such analysis will be integrated by performing suitable case studies and mutually validating the various techniques to test the correctness of the underlying assumptions (both in the context of theoretical models as well as in experimental time series, such as physiological and neural data). A user-friendly software package will be ultimately developed to make the methods accessible to a broad set of potential users, including those with minimal theoretical competences. Furthermore, we will train a new generation of scientists able to implement a broad range of interdisciplinary approaches to the multivariate time signa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Concerted utility review of WER-440 safety research needs (versafe)' (VERSAFE).

assistant: **Innovation**

The high-level objective is to create a network of the safety managers and experts of the plant licensees that are foreseen to operate the VVER-440 reactors within the European Union during the first decades of the next century. For this purpose, the specific features of the VVER'S in the Central European countries will be taken into account.First, an overview on the approaches to two safety management areas with the perspectives in the near future: (1) Severe Accident Management (SAM) and (2) Plant Life Management (PLIM). The harmonization of the utility views is sought in order to obtain maximal benefits of the unified approaches. The primary objective is to define what are the needs for the additional information from the safety research, when developing a generic approach and the plant- specific approaches to the SAM and PLIM issues.The proposed Concerted Action aims at contributing to the preconditions to operate the WER-440 reactors in the future European Union member countries. For this purpose, the specific features of the WER-440 plants in the Central European countries in respect to the already obtained high safety level will be taken into account.The project starts with an overview on the comprehensive approaches to two safety management areas that are of concern for the near future, i.e. (1) Severe Accident Management (SAM) and (2) Plant Life Management (PLIM). The selection of the final approach for the individual plants has to be consistent with the plant-specific features and the national and utility requirements. The proposed project will define the utility views, what are the needs for the additional information from the safety research, when developing a generic approach and the plant-specific approaches to the SAM and PLIM issues.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Review and improvement of testing Standards for Refractory products' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Refractories are materials essential for all highly industrialised processes which are performed at elevated temperatures e. g. iron- and steelmaking, cement production, glass, ceramics, nonferrous metals, power production and waste incineration Refractories have high economical importance and serve a key function for the industry in Europe. In Europe, most of refractory manufactur are SMEs.The technical suitability of refractory products is warranted through physical, chemical and technological materials properties, laid down in data sheets. For the purpose of obtaining those technical specifications, testing methods are described in national and international standardisation systems, like DIN, CEN or ISO.Progressively, the established standard testing methods no longer fulfil the increasing requirements of the refractory market. This project is a response to the need for a systematic investigation of the accuracy, precision and reproducibility of the current EN testing standards for refractories with the aim to enhance their relevance, especially to the specific needs of SMEs.The central objective of this project is to increase the competitiveness of the European SME refractory producers. This will be archived by generating up-to-date EN testing standards as a save guidance for the producers. An extensive investigation of the current EN testing methods, designs of experiments and interlaboratory tests, more specifically collaborative tests, involving the major European refractory testing laboratories will be the key approach to attain this objective. For a successful review of the EN testing standards and an effective dissemination of the results, a strong and broad-based cooperation between transnational partners is planned. For this purpose, the European SME-AG for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'HEMOSNOW: A revolution in haemostatic technology to stop bleeding in delicate surgery and enhance patient recovery' (HEMOSNOW).

assistant: **Innovation**

Excessive blood loss during surgery is a major concern - 42% of all patients who experience excessive blood loss during surgery die. Excessive bleeding contributes to longer hospital stays and delayed post-operative recovery. This incurs costs for both hospitals and patients with increased operating room time estimated to cost €1,542 - €2,554/hour while increased hospital stay is estimated at €1,038/day. Conventional techniques used to control excessive bleeding such as electrocautery are not always feasible and are often restricted to accessible vessels of a minimum size. This limits their applicability and contributes to postoperative drainage and pain. Haemostatic agents are formulations designed to arrest bleeding by supplementing the normal haemostatic mechanism of the body. Most haemostats currently used by surgeons to control bleeding have lengthy preparation times, are difficult to apply and stick to surgical instruments which limits their suitable application. In response, Biom’up has developed HEMOSNOW, a unique haemostatic powder formulation capable of stopping level 1 & 2 bleeding on the SPOTGRADE scale (developed and patented by Biom’up to quantitatively determine bleeding from surgical wounds). This collagen-based powder is ready to use and stops bleeding within 6minutes. It will equip surgeons with an effective tool for rapid and effective haemostasis, reduce operational procedure time and reduce the risk of surgical errors which occur when the surgeon’s vision is obscured by excessive blood. Patients benefit through lower healthcare costs, faster recovery and lower risks associated with blood transfusion. Biom’up is a French biotech company founded in 2005 which specialises in collagen-based resorbable medical devices for biosurgery. This project is expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Topology driven methods for complex systems' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Many complex systems are characterized by multi-level properties that make the study of their dynamics and of their emerging phenomena a daunting task. The huge amount of data available in modern sciences can be expected to support great progress in these studies, even though the nature of the data varies. Given that, it is crucial to extract as much as possible features from data, including qualitative (topological) ones. The goal of this project is to provide methods driven by the topology of data for describing the dynamics of multi-level complex systems. To this end the project will develop new mathematical and computational formalisms accounting for topological effects. To pursue these objectives the project brings together scientists from many diverse fields including as topology and geometry, statistical physics and information theory, computer science and biology. The proposed methods, obtained through concerted efforts, will cover different aspects of the science of complexity ranging from foundations, to simulations through modelling and analysis, and are expected to constitute the building blocks for a new generalized theory of complexity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Advanced System for Foreign Object Debris and Bird-Aircraft Strike Avoidance'.

assistant: **Objectives**

Aeronautic sector is increasingly facing various safety threats to passengers, crews and aircraft caused by foreign object debris (FOD) as well as birds and the growing number of drones on runways and surrounding airport areas. Given the high impact of potential accidents and incidents – damage to aircraft and potential loss of lives – there is a continuous adoption of best practices and technologies to mitigate the risks. Today, most airports rely on periodic vehicle patrols for runway inspections, but such procedures have several limitations. Then, alternative technological approaches are expensive and only detect FOD. Thus, today’s approaches have not been effective, and aviation sector experiences costs that are estimated in +$13 billion/year due to FOD and bird-aircraft strikes.MS3E aims to seize a major market opportunity, offering an innovative solution – the FODBASA. FODBASA has been specifically developed to overcome limitations of existing technologies and to meet the high demand for safety solutions for the aeronautic industry. FODBASA is an autonomous radar-sensor-based system designed for simultaneous detection of FOD, birds and drones. There are no similar solutions in the market. Its unique capabilities come from our innovative and proprietary high-frequency radar sensor that has been successfully developed for military applications and was validated by Danish Defence. Thus, our system allows to provide accurate real-time FOD detection and real-time threat alert for both birds and drones on runways and within a 10-km radius of the airport. Finally, FODBASA is a cost-efficient solution, triggering an attractive business case for any airport serving more than 2.5 million passengers/year.FODBASA will represent the best technology available and a technologica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Knowledge exchange between Europe and America on forest growth models and optimisation for adaptive forestry' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The supply of forest services and products is largely determined by forest management. Decision makers thus need models and tools that may help assess the short and long term impacts of management options on the forest resource base. The biological processes and the temporal and spatial scales involved complicate this assessment. Socioeconomic and climate change as well as the possibility of catastrophic events further complicate it as they lead to a decision-making context characterized by risk and uncertainty. Designing adequate forest decision support models and tools is a thus a very complex task.The European and the American experiences with the development and application of models and tools to support forest management provides a solid foundation for continuous improvement of its efficiency and effectiveness in a context of global change that calls for adaptive approaches. It further suggests networking and research needs to pursue that improvement. This provided the rationale for a project that might strengthen research collaboration through active networking and staff exchange activities between four European organisations from Portugal, Finland, Spain and Sweden, and five American organisations from Chile, Brazil and USA that are leaders in this field. These organisations represent different disciplines (e.g. environmental science, forest inventory and modelling, operations research and software engineering). The project will contribute to a consistent worldwide quality reference for the development of tools that may be used by public administrators, forest owners, industry and non-governmental organisations for enhanced integration of adaptive strategies in forest management planning. Expertise of the partners involved in this proposal is key to achieve the o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Quality and Production Control with Integrated Machine Vision' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Our company, Falcon-Vision was established in 1996 with the aim of developing machine vision tools for the inspection of casted parts. During this time we have produced a number of custom inspection tools that can achieve 100% inspection without contact in real time. We have developed a successful track record and have become established as a supplier of high speed quality control and in-line metrology systems to leading multinationals (Nemak, Daimler, Sanofi, Epcos, Visteon) who produce parts for leading automotive companies (GE, AUDI, Renault, BMW, VW).Our custom-made inspection machines have been a huge success and our sales have increased from 1.2 million Euros in 2009 to 2.2 million Euros in 2013 and will be almost doubled in this year. This increase is not surprising based on our high quality products and the list of satisfied customers; however we are striving to increase the sales and satisfy the rising demands due to our machines being custom made. Recently, our customers’ demands have been also widening. They are requiring faster, simpler and more flexible measuring machines. After discussions with our customers we have come to the conclusion that the best way to increase our productivity and satisfy more customers would be to make our system modular which would help the customer pick and choose the different inspection modules in a flexible and efficient way. This would mean we can mass produce the modules which would speed up the service and reduce the price. In addition, development of new innovative modules is also foreseen to further improve the accuracy and to give the opportunity to inspect such geometries which were not possible in the past.The new modular approach will help halve the production lead time of the inspection machine and also reduce the c