RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fostering Synthetic Biology standardisation through international collaboration' to be submitted under Horizon 2020.

assistant: **Abstract**

Synthetic Biology is an engineering research field aiming at (re)designing biological circuits for applied purposes. As any other engineering field, it strongly relies on the use of well-defined, universal and robust standard components. The outstanding success of synthetic biology in the last years should not hide the difficulties in defining biological standards. There are both historical and technical difficulties to reach that ambitious goal. On the former: the crossroad nature of synthetic biology involving mainly biologists/biotechnologists and engineers, whose views on thestandardisation of living beings tend to differ; among the latter: the intrinsic features of live (mutation, emergent properties, fitness biasses, variability and, of course, evolution). In BIOROBOOST we propose to finally overcome cultural issues and to dramatically advance in solving technical difficulties by i) gathering the most relevant stakeholders of all the aspects of standardisation in biology in Europe in a co-creation scenario; ii) by empirically testing cultural (lab-centric) standardisation practices and by promoting a consensus conceptual and technical redefinitionof biological standards; and, finally, iii) by fostering a realistic and flexible toolbox of standard biological parts, including a reduced set of specialised chassis for specific applications as well as a renewed conceptual framework to inform policy makers, scientific and other societal actors.


**Keywords:** standards, international coordination
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Construction of microcompartments in thermophilic Geobacillus thermoglucosidasius as nano-bioreactors for advanced biofuels production at high temperature' (THERMCP) under Horizon 2020.

assistant: **Objectives**

Geobacillus spp are thermophilic Gram positive bacteria which are specialists in the degradation of hemicellulose derived from renewable biological feedstocks and the supervisor’s group has recently engineered strains able to degrade cellulose. Some of the strains are facultative anaerobes which can grow anaerobically and produce fermentation products such as lactate and ethanol. Hence they are an ideal platform for producing fermentation products from renewable carbohydrate resources, such as lignocellulose. Recent genome sequencing has shown that some strains have the ability to produce proteinaceous micro-compartments, known from other organisms to host reactions which produce unstable/highly reactive intermediates, and these have been observed by EM analysis in the lab of the supervisor. In this project the MC fellow will exploit some novel technology under development in the lab of the supervisor to develop thermostable alpha-keto acid decarboxylases, which are not typically present in thermophiles. These produce reactive aldehydes which cause toxicity to producing cells, even in the presence of a cognate alcohol dehydrogenase, but this can potentially be reduced by targeting the decarboxylase and alcohol dehydrogenase to a protein micro-compartment. Therefore, the aim of this project is to establish the rules for targeting enzymes to protein micro-compartments in Geobacillus spp and exploit these using thermophilic decarboxylase – dehydrogenase combinations to produce 1) ethanol, 2) isobutanol. The final constructs will be evaluated against real lignocellulosic feedstocks in the lab of the industrial collaborator ReBio Ltd. The project will provide an in depth training in metabolic and cellular engineering, employing synthetic biology strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'High power battery technology for electric power supply applications' to be submitted under Fourth Framework.

assistant: **Abstract**

The objective of the project is the development of a new Na/S battery technology for high power stationary applications. In contrast to the Japanese technical orientation towards energy storage plants for low-power load-levelling, which have now reached their technical maturity and are currently being commercialised, this project aims at modular high-power batteries for spinning reserve and standby applications such as for air conditioners, domestic and bureau appliances and other electric utilities. Related fields of application for this new type of high power battery are uninterrupted power supply systems and load-levelling in connection with decentralised, selfsufficient energy generation with renewable energies, e.g. solar energy. The conventional energy storage technology works with Pb-Acid- or Ni/Cd-batteries. Comparing the Na/S- and the advanced Pb-Acid- and Ni/Cd-battry technology, the paramount disadvantages of the latter are a much smaller energy density and power density, the requirement of constant supervision, control and maintenance by specially trained personnel, and the polluting partial recycling and removal respectively. In contrast the proposed modular stationary Na/S battery works maintenance free, is safe by design and friendly to the environment. The shortcoming in the technologies of the European manufacturers of Na/S-batteries for electric vehicle applications was mainly due to the single electrolyte-single cell concept. Under heavy duty operations this concept proved inadequate. The overall cell resistance due to the single cylindrical design of the ceramic electrolyte proved to be too high because of the restricted surface area of the ceramic electrolyte. High power demands, e.g. during vehicle acceleration, led to high current densities in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Federated Active Linguistic data CuratiON', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This project will deliver a modular software platform that will enable SMEs in the localisation industry to leverage open language resources published by public bodies. This platform will bootstrap a commercially sustainable localisation process that allows SME Language Service Providers (LSPs) to continuously reuse the output of web content translation projects. By integrating these outputs with language resources from public bodies, SME LSPs can easily and cheaply optimise and tailor open source machine translation and automated terminology extraction components to the needs of their customers. Today, the curation of parallel text involves the publication of the undifferentiated results of translation projects in differing formats or via centralised repositories. This restricts SMEs in leveraging these resources to train machine translation engines to match incoming translation projects. FALCON will enable the controlled sharing and reuse of language resources, combining open corpora from public bodies with richly annotated output from commercial translation projects. Federated access control will enable sharing and reuse of commercial resources while respecting business partnerships, client relationships, competitive and licensing concerns.  Fine grained traceability language resource reuse will enable return on investment calculations on resource curation in public bodies and SME LSPs alike. The consortium combines academic expertise in localisation interoperability, linked data management, statistical machine translation and statistical parsing with SMEs offering services and solutions for translation and terminology management. This project will enable the language service industry to realise its potential as a major sources of shared linked data by measurably imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Extracellular matrix derived products from human placenta to engineer bone microtissues for in vitro disease models.'.

assistant: **Innovation**

The aim of ‘AMNIOGEL’ is the development of human extracellular matrix (ECM) based materials, as radically innovative,highly versatile human-derived platforms for 3D cell culture, microtissue development and disease models establishment. Inparticular, we will develop 3D disease models that could be used as an enabling tool for personalized drug discovery,increasing our understanding of the mechanisms behind bone cancer.The proposed cutting-edge technology enables the culture of human cells in a physiologically relevant microenvironment forapplications in cell culture research, drug screening and development, cancer research, tissue engineering, replacement ofanimal testing and therapeutic applications. The potential of this technology to reduce or completely replace use of animalsfor biological screenings is expected to have a significant impact in the 3D cell culture market and pharmaceutical industryby accelerating drug screening and development reducing associated costs. The innovation potential of our products isbased on the fact that contain human biochemical cues (vital for cell function), is a complete xeno-free solution (avoidscontamination) for human cell culture and easy to manipulate. It is worth mentioning that offers the possibility to bepersonalised (using the patient’s own ECM) according to the customer needs. Moreover, our culture substrates are easilyprocessed in multiple geometries and in microarrays amenable to ‘organ-on- a-chip’ systems designed for high-throughputscreening (HTS) applications.


**Keywords:** 3D cell culture, hydrogels, personalized medicine, disease model, osteosarcoma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cosmology with future large-scale surveys' (COSMOFLAGS) under Horizon 2020.

assistant: **Objectives**

New challenges for large galaxy surveys:Forthcoming galaxy surveys will probe volumes much larger than current ones, and measuring galaxy clustering at these scales will represent a new challenge that has not been properly analyzed so far.This project aims at developing a theoretical understanding and a pipeline to maximize the scientific output of forthcoming galaxy surveys, by modeling and making available to the scientific community a way to fully use the cosmological volumes probed, without introducing any bias due to an incorrect treatment of large-scale galaxy clustering.This project plans to develop and apply an improved formalism to data from current and future galaxy surveys to perform precise cosmological tests using galaxy clustering analyses.We will also perform an accurate forecasting of performances of instruments in different configurations and for different observing strategies; this will help defining and optimizing the survey strategy and final implementation of next generation experiments like Euclid and the SKA.The interaction between the researcher and the host institution will allow the development of a formalism for describing and measuring the large-scale galaxy bispectrum, a fundamental ingredient of next generation measurements from cosmological surveys.Finally, we will investigate the optimal way to combine two future experiments of great interest for the European scientific community: Euclid and the SKA.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Crystallographic analysis of protein kinase c' (1994-1998).

assistant: **Concept**

Protein kinase C (PKC) is a multi-domain serine/threonine kinase that is activated by diacylglycerol (DAG), a short-lived derivative of phosphatidylinositol, 4,5-biphosphate (PIP2) and phorbol esters. The kinase activity of PKC is regulated by its N-terminal region that contains the binding sites for DAG and phorbol esters (C1 domain) and Ca2+ and phospholipids (C2 domain). The PKC family includes several isozymes which define two distinct groups; the Ca2+-dependent (cPKCs) and the Ca2+-independent (nPKCs). The inability of nPKCs to be regulated by Ca2+ has been attributed to the absence of a classical C2 domain. We have recently expressed large quantities of a C2-like domain of a novel PKC (nPKC) in E. coli . We have successfully obtained crystals of this domain suitable for X-ray analysis. We therefore intend to determine the structure of this domain. Moreover, there is recent evidence that this domain influences the interaction between PKC and one of its substrates (Dekker & Parker, data unpublished). Once the crystal structure of this domain has been determined, we will pursue co-crystallization trials of PKC bound to interacting peptides derived from the substrate. Individual domain structures provide an insight into the binding sites for activating ligands of PKC. However, they do not address the overall architecture of the full length molecule or the specific domain:domain interactions. Such interactions may ultimately define the mechanism of regulation of full length PKC. In parallel to our efforts with the C2-like domain, we intend to prepare constructs of the entire catalytic and regulatory domains and to produce such constructs in E. coli . Our current success with the C2-like domain, has encouraged these efforts. Moreover, full length novel PKC isozymes have
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Mathematical Structures in Scattering Amplitudes'.

assistant: **Concept**

Among the most important mathematical quantities of interest in high-energy particle physics are the so-called scattering amplitudes, which allow us to make predictions for physical observables. Despite their importance, performing explicit computations of scattering amplitudes is still one of the bottlenecks of high-energy physics, mostly due to the complexity of the integrals involved and a lack of understanding of the underlying mathematics. Over the last couple of years, a deep connection between scattering amplitudes and certain branches of modern mathematics has slowly started to emerge. The goal of MathAm is investigate in detail the relationship between scattering amplitudes, number theory and algebraic geometry, with the final aim of developing novel computational techniques for scattering amplitudes that are beyond reach of conventional state-of-the-art technology.The ultimate goal of MathAm is threefold: By revealing unexpected connections between seemingly disconnected areas of mathematics and physics, MathAm will 1. shed new light on the mathematical underpinnings of the fundamental laws of Nature in general.2. play a decisive role in testing recent conjectures about the all-loop structure of certain special classes of gauge 3. theories by confronting them to the explicit results for scattering amplitudes,3. set a new standard for making predictions for collider experiments like the LHC by performing computations that are beyond reach of current technology. To sum up, MathAm has a unique multi-disciplinary character and, by applying novel technology from modern mathematics, its results will have impact in various seemingly disconnected disciplines, ranging from the frontiers of research in pure mathematics over formal aspects of Quantum Field Theory all the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integration Europe's Mobile ICT Community - Networking Innovation Activities, Entrepreneurs, Clusters and Leading Stakeholders in the Mobile Information and Communication Technology Sector' (MCLUSTERS).

assistant: **Innovation**

The mClusters project gets its distinctive qualities from its main objective: To benefit more from local innovation clusters, which are globally connected, while shaping better mobile Information and Communications Technology (ICT). The project brings together groups of advanced users of such information society technology with relevant experts from academia, industry and supporting institutions to foster the exchange of best practices for creating new applications and diffusing related knowledge.The project should create synergies among regional as well as pan-European projects by strategic matchmaking and collaboration between investors, high-tech firms, and technology specialists at universities and other R&D centres. The mClusters project puts emphasis on the effectiveness in clustering of competencies regarding mobile ICT, especially technology that cuts across sectors through a variety of new, comprehensive, and user-oriented applications. The project builds on experiences gained through PAXIS projects, Gate2Growth activities and the Hubs & Regions consortium of 35 R&D centres across Europe, involving nearly 69 researchers in research and development work. In its ambition to link geographically anchored clusters across sectorial borders, the mClusters project should attain useful insights of success factors and weaknesses in the clustering of companies applying ICT in various sectors.Eight European regions with significant clusters of special competencies are targeted for immediate action, including joint projects/programs among the clusters. For each of them, cross-cluster collaboration is perceived as a priority. Yet, in the project, the comparison and diffusion of success factors and best practices will go beyond these to include other existing and new clusters
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Gaia European Network for Improved data User Services'.

assistant: **Objectives**

GENIUS is designed to boost the impact of the next European breakthrough in astrophysics, the Gaia astrometric mission. Gaia is an ESA Cornerstone mission scheduled for launch in October 2013 and aims at producing the most accurate andcomplete 3D map of the Milky Way to date. A pan-European consortium named DPAC is working on the implementation of the Gaia data processing, of which the final result will be a catalogue and data archive containing more than one billion objects. The archive system containing the data products will be located at the European Space Astronomy Centre (ESAC) and will serve as the basis for the scientific exploitation of the Gaia data. The design, implementation, and operation of this archive are a task that ESA has opened up to participation from the European scientific community. GENIUS is aimed at significantly contributing to this development based on the following principles: an archive design driven by the needs of the user community; provision of exploitation tools to maximize the scientific return; ensuring the quality of the archive contents and the interoperability with existing and future astronomical archives (ESAC, ESO, ...); cooperation with the only other two astrometric missions in the world, nanoJASMINE and JASMINE (Japan); and last but not least, the archive will facilitate outreach and academic activities to foster the public interest in science in general and astronomy in particular.  GENIUS fits seamlessly into existing Gaia activities, exploiting the synergies with ongoing developments. Its members actively participate in these ongoing tasks and provide an in-depth knowledge of the mission as well as expertise in key development areas.Furthermore, GENIUS has the support of DPAC, several Gaia national communities in the EU m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DISCOVERER – DISruptive teChnOlogies for VERy low Earth oRbit platforms', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

We envision a radical redesign of Earth observation platforms for sustained operation at significantly lower altitudes than the current state of the art, using a combination of new aerodynamic materials, aerodynamic control and air-breathing electric propulsion for drag-compensation, for a variety of observation methods with the aim of creating a new platform paradigm.This vision requires foundational research in spacecraft aerodynamic characterization, in material aerodynamics and atomic oxygen resistance, in electric propulsion, and control methods. These activities are by their nature multidisciplinary covering atmospheric science, surface chemistry and material characterization, control engineering, spacecraft design, payload engineering, etc.


**Keywords:** spacecraft platform, very low earth orbit, spacecraft orbital aerodynamics, air-breathing electric, propulsion