RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Co-creative living labs for CWE' to be submitted under Sixth Framework.

assistant: **Abstract**

The overall objective of the CoreLabs CA is to achieve a coordination of activities towards the establishment of co-creative Living Labs as the foundation of a Common European Innovation Infrastructure concept on several levels.The activities to be coordinated towards that goal are:- The harmonisation of existing and emerging Living Labs- Initiatives within current and future CWE research initiatives (primarily Integrated Projects)- Regional, national and IST RTD programmes- All stakeholder organisations (public, academic, civic, industry, SMEs, etc.)This includes the co-ordinated synergic development, harmonisation and networking of regional Living Labs initiatives, research projects, the establishment of a Living Labs Certificate and the creation of a common European Roadmap on relevant research topics.The concept of Living Labs" is relevant to the necessities of evaluating the mass deployment potential of ICT enabled Collaborative Working Environments solutions that stem from the results of re-search projects. Living Labs represent regional innovation environments focussing on user communities embedded within "real life". Additionally to the technological aspects Living Labs allow insight on to the human dimension of technology, which is of paramount importance for a successful societal deployment of new technologies. As a consequence of this potential, the Living Lab approach is considered as the natural candidate for the implementation of large scale evaluation, demonstration and validation activities related to ICT RTD."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DIGITal ENcyclopedia of European Sociability' to be submitted under Horizon 2020.

assistant: **Abstract**

The Digital Encyclopaedia of European Sociability (DIGITENS) project will produce the first open-access digital encyclopaedia and anthology of sociability in Europe throughout the long-eighteenth century. The purpose of the DIGITENS project is to build an original framework for understanding the interactions, tensions, limits and paradoxes underlying European models of sociability and to reflect on the following question: Can the emergence and formation of European models of sociability be traced throughout the long eighteenth century (1650-1850)? Drawing upon the expertise of international members from different disciplines and national traditions, the project will create a toplevel interdisciplinary network and facilitate intersectoral communication between its academic and non-academic partners.The nine international universities will work together with the Bibliothèque Nationale de France, Musée Cognacq-Jay in France, and The National Archives in Great Britain, allowing members to explore how understandings of sociability might be enhanced through dialogue, international collaboration, and digital technology, developing a broader contextualisation of the research into European sociability. As the first digital encyclopaedia of its kind, the expected impact of the resource will not only benefit researchers, but anyone interested in the history of European models of sociability. The project is not, however, of purely historical or academic interest. Through the implementation of outreach events, workshops and the production of the accessible digital platforms, the DIGITENS team will promote a wide investigation of the value of eighteenth century principles in twenty-first-century private and public lives throughout Europe. The interdisciplinary and international aspec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Human pluripotent stem cell differentiation, safety and preparation for therapeutic transplantation in Huntington’s disease' (REPAIR-HD) under Seventh Framework.

assistant: **Objectives**

This project will tackle the huge complexity of taking stem cell therapies to clinical application for neurodegenerative disease by focusing on selective differentiation of a single neuronal phenotype (medium spiny striatal neuron: MSN) for a single well-defined disease (Huntington’s: HD). Our consortium contains expertise in all elements required to drive this technology to the point of clinical delivery, including expertise in stem cell differentiation and control of proliferation; in vitro genetic, molecular, cellular and functional characterisation; preclinical assessment in both rodents and primates models of HD; GMP knowledge, development and production; and clinical translation. Our clinical team includes world leaders in HD clinical trials, including fetal neural transplants and is well placed to design the translation process. We focus on human embryonic stem (hES) cells as our primary target for first-in-man proof-of-concept studies, as they are closest to clinical readiness. HD is the target disease as it provides both an excellent model relevant to a wide range of neurodegenerative conditions, and is a stringent test of the capacity of selectively differentiated stem cells to repair neural circuits. The starting point for the work is the existence within the consortium of three of the most advanced protocols to date for MSN differentiation, and a feature of our consortium is that the specificity of stem cell differentiation will be tested against primary fetal MSNs (current gold standard) at all stages of both in vitro and in vivo assessment. In order to maintain flexibility in an emerging ethical environment, we will develop induced pluripotent (hiPS) cells to the point of GMP validation as a second generation target to hESCs. This will build European infra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integration of biodiversity monitoring data into the Digital Twin Ocean' (DTO-BioFlow) under Horizon Europe.

assistant: **Objectives**

The ocean and its biodiversity are essential to life on this planet. Comprehensive data on biodiversity, and related human and environmental pressures are crucial to understand its current state and how this may change. Protecting and restoring biodiversity is one of three objectives of the Horizon Europe Mission to restore our oceans and waters by 2030, enabling the EU to reach its Green Deal and Biodiversity 2030 targets. Identified as one of the Mission ""enablers"", the EU will build on “a digital knowledge system” to include a Digital Twin of the Ocean (DTO) allowing simulation of ‘what if’ scenarios, advancing ocean knowledge, informing evidence-based policy and offering a range of societal applications. To effectively replicate the ocean’s ecology, the DTO requires sustained flows of data on biodiversity and associated pressures. Despite myriad actors collecting biodiversity data, and the development of novel cost-effective monitoring technologies, much of these data are inaccessible or unusable for a variety of reasons, hampering the development of the DTO biological component and limiting its efficacy. DTO-BioFlow will activate access to (""sleeping"") marine biodiversity data and enable the sustainable integration of existing and new Artificial Intelligence processed and automated data flows from various sources to EMODnet and into the EDITO infrastructure serving the EU DTO. Combining sustained data flows, models and new algorithms, DTO-BioFlow will develop and integrate the biological component of the DTO, including new digital tools and services. Policy-relevant use cases, will demonstrate the benefit for marine ecosystems of continuous data streams flowing through EMODnet and usable by the EU DTO infrastructures and ultimate end-users. Mobilising the marin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Standardization of hip fracture audit in Europe'.

assistant: **Concept**

. To devise and agree a standard data set for documentation of case mix, surgical management, rehabilitation management and outcome of hip fracture throughout Europe.. To pilot the use of such a data set in range of settings throughout Europe.. To facilitate Europe-wide comparisons of demographic features, surgical technique and rehabilitation arrangements.. To demonstrate the feasibility of standardised collaborative and Europe-wide audit of hip fracture.. To evaluate across Europe the effectiveness of hip fracture care in terms of mobility achieved, proportion of cases returned home and minimisation of dependency.. To compare across Europe the efficiency of hip fracture care in a variety of settings by documenting use of acute care beds and post-acute rehabilitation facilities.. To facilitate the dissemination of best-practice hip fracture surgery and rehabilitation throughout Europe.Hip fractures constitute one of the most resource-consuming conditions needing healthcare in the western world. In Sweden these patients occupy 25% of allorthopedic bed days. The number of hip fracture patients will continue to increase due to both an increasing elderly population and an increasing incidence of fractures. Due to the age of the patients and other concomitant diseases they often need a chain of different treatment levels as well as social support. A large scale audit of hip fracture treatment will give answers of daily practise and its results and comparison internally over time and externally with other centres will lead to optimised treatment of benefit for the independent life of the patient, the efficiency of the health care system and the economy of the society.Objectives:1. To devise and agree a standard data set for documentation of case mix, surgical management, reh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector' (STADVINN) under Seventh Framework.

assistant: **Objectives**

CD8+ T cells play a key role in the control of infections by intracellular pathogens. Recently, several top-notch studies provided ample evidence that NK cells are important in the regulation of CD8+ T cell response. NKG2D is an activating NK cell receptor which plays a role in the adaptive immune response by co-stimulating CD8+ T cells. Due to unique pattern of immune response, live attenuated CMVs are attractive candidates as vaccine vectors for a number of clinically relevant infections. The main idea behind this project stems from our preliminary data which suggest that a recombinant CMV vector expressing NKG2D ligand has a tremendous potential for subverting viral immunoevasion and boosting the efficiency of CD8 T cell response.During the project we plan to systematically investigate the impact of all major innate immunity players on the CD8+ T cell response. A special focus will be given in obtaining new knowledge on the maintenance of memory CD8+ T cells during latent infection. This study will also provide novel insights on the role of NKG2D in both NK and T cell immunity. In order to test our hypothesis in vivo, we will employ state-of-the-art technology used in herpesvirus genetics coupled with high-end immune monitoring. Ultimately, we will translate our results to a human CMV vector, in order to gauge the impact of NKG2D signaling on immune response in a humanized mouse model.We believe that the significance of the proposed study is enormous since stimulating CD8+ T cells has been widely recognized as a method of choice for vaccine development. There are relatively large number of pathogens for which the immunity acquired post-infection does not fully shelter against re-infection and disease. Therefore, we are in a desperate need for vaccines which offer sup
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Studying Cancer Individuality by Personal and Predictive Drug Screening and Differential OMICs' (SCIPER), addressing dissemination and exploitation.

assistant: **Impact**

The cellular and molecular systems that determine drug responses in cancer are complex, highly individual, and incompletely understood. As a result, many cancer patients receive ineffective or even harmful therapies, which endangers lives, burdens healthcare systems, and prevents new therapies from reaching clinical approval.To address this problem, we are developing a platform that measures hundreds of ex vivo drug responses from small patient biopsies by immunofluorescence, automated confocal microscopy, single-cell image analysis, and machine learning. We preserve cellular memory and maximize physiological relevance by not culturing or sorting cells prior to drug exposure. Sub-cellular, single-cell, and cell population-wide image analysis reveals on-target drug responses and disentangles multicellular ones. In a first interventional clinical trial, this phenotypic information alone led to strongly improved treatment of patients with aggressive hematologic malignancies.Enabled by this high-throughput, predictive, and phenotypic information, I here propose to identify the molecular and cellular systems that govern treatment response individuality in cancer. (Aim 1) We will combine drug response profiling with RNA sequencing and proteomic measurements of malignant and healthy cells from the same biopsies. Critically, the patient-internal comparisons in both screening and OMICs allow neutralizing complex confounding factors. (Aim 2) New multiplexed immunofluorescence and convolutional neural network-based analyses will identify multiclass cell-types and -states, and quantify non-cell-autonomous responses. (Aim 3) Computational integration and causal inference will identify the molecular determinants and governing principles of drug response individuality in cancer, amena
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Corporate finance in transition economies' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The objectives of my research activities will be two-fold; firstly, to understand the patterns of corporate finance in transit economies, with focus on Russia; and secondly to draw policy conclusions for EU authorities concerning foreign investment and the set-up of a well-functioning financial system. The following steps are proposed: 1. To examine the extent to which internal and external finance is used by firms within transition economies. Contrasting with industrialised EU-countries and development in transition economies over time 2. To examine the usage of different forms of external finance Developing an integrative model for the choice of external finance ('control-oriented' versus 'arms-length' and for t categories 'debt' versus 'equity') and testing it empirically 3. To examine the institutional choices involved Examining (empirically and theoretically) mainly the role of investment funds and foreign investors from EU-countries corporate governance 4. To derive policy measures to influence the patterns of corporate finance of transition economies for authorities in the (regulation and support of foreign investment) and in transition economies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'THE COLOUR OF LABOUR: THE RACIALIZED LIVES OF MIGRANTS' (COLOUR).

assistant: **Concept**

This project is about the racialization of migrant labourers across political boundaries, with a main focus on impoverished Europeans who served in huge numbers as indentured labourers in nineteenth-century Guianese, Caribbean and Hawaiian sugar plantations and in the workforce of late nineteenth and early twentieth century New England cotton mills. With this project I aim to provide major, innovative contributions on three fronts: (i) theory-making, by working the concepts of race, racism, racialization, embodiment and memory in association with migrant work across political boundaries and imperial classifications; (ii) social relevance of basic research, by linking an issue of pressing urgency in contemporary Europe to substantive, broad-scope, and multi-sited anthropological/historical research on the wider structures of domination, rather than to targeted problem-solving research of immediate applicability; (iii) disciplinary scope, by proposing to unsettle historical anthropology and ethnographic history from within the boundaries of a single empire, and to overcome the limitations of existing comparative studies, by inquiring into the flows and interactions between competing empires. I will also: (iv) strengthen the methodology for multi-sited, multi-period research in anthropology; (v) contribute to an anthropology of global connections and trans-local approaches; (vi) promote the multidisciplinary and combined-methods approach to complex subjects; (vii) narrate a poorly known set of historical situations of labour racializations involving Europeans and document the ways they reverberate through generations;  and (viii) make the analysis available to both academic audiences and the different communities involved in the research.


**Keywords:** RACE,  RACIALIZATI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A new platform technology for the on-demand access to large acenes' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The aim of PLAT_ACE is to study the technical and commercial viability of this novel synthetic methodology and its industrial implementation for the generation of nonacene and other larger acenes supported onto surfaces for use in semi-conducting devices with unprecendeted electronic properties and low bandgap. Our technology will be benchmarked against current industrial methodologies to identify the unique selling points and niche applications.We will demonstrate the application of the new acenes as organic based transistors and for other electronic applications by their controlled deposition ofdifferent surfaces.


**Keywords:** Acenes · Organic synthesis · Catalysis · Metal surfaces · Molecular electronics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'End-to-End Remote Site Monitoring and Clinical Trial Management Solution' under Horizon 2020.

assistant: **Concept**

Clinical trial costs have been constantly on the rise in the last years the total cost of a single big trial can reach €600 million. The increasing costs have significant implications for public health, as it affects pharmaceutical and biotech companies’ willingness to undertake clinical trials, which in turn limits patient access to novel treatments. To monitor clinical trials, it is a common practice to conduct site visits frequently and to verify source data during these visits. On-Site monitoring accounts for up to 14% of overall clinical study costs.These costs can be reduced by making wider use of mobile technologies, centrally available data to evaluate site performance, electronic data capture, and other efficiency-improving options.Existing systems on the market do not offer solutions to the problem. There are systems for clinical trial financial management; systems for electronic data capture; systems that provide access to electronic health records (EHR) and lab results (e-source) or access to mobile health devices. All these separate systems do not necessarily talk to each other, staff at clinical research sites report usage of three different systems to enter patient/study data.Citrus - Clinical Trial Management & Remote Monitoring is the first revolutionary solution to offer remote monitoring capabilities. It is an end-to-end solution which includes CTMS, direct access to lab results and EHR, access to mHealth devices and it ensures data privacy compliance when data is accessed remotely.Founded in 2008, CRU Hungary leads the clinical research services in Center-East Europe. Their 4 clinical research sites are preferred companies such as Pfizer, AstraZeneca and GSK. Our IT department have been developing solutions that answer to real pains in the clinical t