RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The role of the virome in shaping the gut ecosystem during the first year of life' in the context of a Horizon 2020 call.

assistant: **Objectives**

The role of intestinal bacteria in human health and disease has been intensively studied; however the viral composition of the microbiome, the virome, remains largely unknown. As many of the viruses are bacteriophages, they are expected to be a major factor shaping the human microbiome. The dynamics of the virome during early life, its interaction with host and environmental factors, is likely to have profound effects on human physiology. Therefore it is extremely timely to study the virome in depth and on a wide scale. This ERC project aims at understanding how the gut virome develops during the first year of life and how that relates to the composition of the bacterial microbiome. In particular, we will determine which intrinsic and environmental factors, including genetics and the mother’s microbiome and diet, interact with the virome in shaping the early gut microbiome ecosystem. In a longitudinal study of 1,000 newborns followed at 7 time points from birth till age 12 months, I will investigate: (1) the composition and evolution of the virome and bacterial microbiome in the first year of life; (2) the role of factors coming from the mother and from the host genome on virome and bacterial microbiome development and their co-evolution; and (3) the role of environmental factors, like infectious diseases, vaccinations and diet habits, on establishing the virome and overall microbiome composition during the first year of life. This project will provide crucial knowledge about composition and maturation of the virome during the first year of life, and its symbiotic relation with the bacterial microbiome. This longitudinal dataset will be instrumental for identification of microbiome markers of diseases and for the follow up analysis of the long-term effect of microbiota
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'High performance low cost motorcycle helmets' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of the project is to carry out a research and development programme aimed at developing an innovative motorcycle helmet, that may be regarded as the prototype for the next generation of helmets. The principle behind the research is to increase the safety of helmets as part of a wider concept that can be summarised as follows: The two areas of research described above are closely interconnected because it is necessary to proceed with a complete redesign of helmets in order to integrate the properties listed. An organic R&D action is extremely important for European producers because the average technological level of output is inferior to that of competitors and the development of innovative and low cost technologies and production processes requires a major effort that the industries are unable to make individually at present. One of the most innovative aspects of the helmets to be developed will be the capacity to reduce internal noise levels. This aspect is not taken into consideration at present in existing motorcycle technology although recent research has shown that even at moderate speed the level of noise inside the helmet, which is mainly due to aerodynamic rustle, may reach extremely high values (95dB at 90 Km/h). This reduces the comfort of the rider and prevents him/her from hearing surrounding sounds that might warn of danger. The answer to this problem may lie, first of all, in the most advanced passive acoustic technologies, which allow selective absorption of sound and only keep back undesirable noise. In addition, aerodynamic studies and research on materials may help to alter the frequencies produced inside the helmet so that they differ from those to which the human ear is most sensitive (1250. 1500 Hz).  This will require careful analysis of s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Integrating environmental and population variation: a model for biodiversity studies' in the context of a Fourth Framework call.

assistant: **Objectives**

Biodiversity expresses the variety of organisms and the variety of habitats. We currently have no good general explanations for the dynamics and distribution of biodiversity. Objectives: - Understanding ecosytem-organism interactions generating biodiversity; - Devising measures to quantify the expression of biodiversity. Achieving objectives: - Quantifying organismal variation in relation to levels of gene flow; - Mapping this variation onto environmental variation; - Quantifying relative roles of phenotypic, genotypic and environmental variation in the generation of biodiversityi - Determining the nature of reproductive barriers between populations in different species. The environment - The rocky intertidal, presenting a linear, patchy environment with a pronounced gradient, providing a continuum of changing habitats. The organisms - Periwinkle snails (Mollusca: Gastropoda)- ecologically  important grazers; - Provide the range of population genetic structures needed for this study, building on an existing body of foundation work. Techniques - Phenotype - analysis using multivariate methods on shell  shape, and thermal tolerance to determine the adaptive extent of physiolo gical variation; - Genotype - electrophoretic determination of enzyme polymorphisms, two-dimensional electrophoresis of general proteins, analysis of myoglobins for non-enzymatic protein variation, molecular techniques to determine DNA polymorphisms so as to compare these measures with enzyme based approachesi - Some techniques are novel, needing to be developed in this study. Towards an operational concept of biodiversity: - We shall elucidate mechanisms in the transition from polymorphic, interbreeding populations to those of species status, and investigate the distinction from phenotypic plasticit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'NLF Wing High Speed Performance Test' in the context of a Seventh Framework call.

assistant: **Objectives**

The primary innovative approach and the major aim of the investigations being covered here is in the first instance to perform reliable and high quality procedures for laminar wing testing under and near flight conditions at high Reynolds numbers in ETW. Beside confirming a number of already mature and successfully applied measuring techniques, these investigations will allow to validate a new evaluation process by quantitatively determining areas of turbulent flow on the wing, e.g. generated by turbulent wedges inside the laminar flow region.. Calculating the difference in drag due to laminar and turbulent flow by post-processing forms a tool for correcting the overall drag as measured by the balance.A second subject of interest is the surface quality of the model to be tested. Special attention will be given to the cleanliness of the model on preparation and the eventual contamination while testing.The experiments will improve the understanding of the flow and the performance of airplanes and are an indispensable tool for airframe manufacturers. At the end the project will help to safe resources like fuel, to reduce the pollution of environment by exhaust gases and noise and finally to increase the safety of flights.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Targeting environmental pollution with engineered microbial systems á la carte', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Synthetic Biology-SB- deals with rational combination of biological properties with central elements of engineering design. By merging the genetic tool box already available with engineering disciplines & computer sciences there is a great opportunity for a new approach to environmental pollution problems through application of modelling techniques & organizing development of novel biological systems across a hierarchical architecture with defined & standardized interfaces. However this faces 3 major bottlenecks:  -The scientific & technical European contributors on SB have so far failed to recognise their latent capacity to shape a fresh discipline at their very interface -SB still lacks a comprehensive language & shared conceptual frame for the description of minimally functional biological parts -The development of SB touches on social sensitivities related to recreating life-in-the-test-tube which threatens to re-awaken the GMO controversy. Thus scaring off the necessary industrial input in the field. To tackle these challenges, we propose a 2-year program run by a large expert group to coordinate the fragmented efforts & direct this discipline into the most industrially beneficial and socially viable directions. We aim to energise and mobilise the European scientific, technical & social professionals to empower a new capacity to exploit properties present in Biological systems for environmental issues. TARPOL will recruit the required environmental competences from neighbouring disciplines and will set up a number of material and computational resources for advanced refactoring of biological systems. We will establish a frame consensus for procedure and parts standardization and pursue the awareness and eventual insertion of SB into the Environmental Biotechnology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unlocking the scientific excellence and innovation capacity of the University of Aveiro in supramolecular multicomponent biomaterials for enabling advanced biomaterials for healthcare' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

SUPRALIFE addresses current hurdles of UAVR in the supramolecular biomaterials chemistry field regarding its scientific know-how and partnerships with world-leading institutions. UAVR seeks to improve the multifunctionality of biopolymers, often with limited bioactivity, stimuli-responsiveness and mechanical properties, and increase their performance in biomedical applications. Biopolymers integration with self-assembling motifs would enable the development of innovative supramolecular architectures with bioinstructive and adaptive behaviour for enhanced cellular response, drug delivery and diagnosis. SUPRALIFE aims to surpass UAVRs limited knowledge and expertise on non-covalent synthesis by launching an international scientific and training network to accelerate the pace on developing complex and innovative supramolecular multifunctional biomaterials to interface with living systems. The consortium encompasses UAVR and two internationally-leading institutions, TU/e and UBx, that will critically enhance UAVRs scientific excellence, innovation capacity, and reputation in supramolecular chemistry and translational self-assembling biomaterials. UAVRs capability to train highly-qualified researchers and staff will significantly increase, giving rise to a next-generation of specialised professionals with scientific and translational competences. SUPRALIFE proposes the organisation of joint events, networking activities, short-term on-site trainings and staff exchanges, expert visits, and an exploratory research project for stepping up and stimulating UAVR scientific excellence and innovation capacity. Outputs include increasing the track-record and quality level of publications, IP, innovative biomedical products and regional-to-national economic development. SUPRALIFE will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Elucidating drivers of human Inflammatory Bowel Disease by next-generation organoid modeling' (EDIOM) under Horizon Europe.

assistant: **Objectives**

Inflammatory Bowel Disease (IBD) is a collective term for bowel diseases caused by undesired immune reactions and can currently not be cured. To develop adequate treatments for IBD, we need to understand the nature and cause(s) of the pathogenic immune responses observed.To identify mechanisms driving IBD in humans, we need apart from diagnostic correlative studies, adequate in vitro cell models that realistically recapitulate the in vivo situation and allow for intervention studies. Thus far, in vitro models that incorporate next to intestinal epithelium also supportive stroma and immune cells are lacking. In my PhD studies, I generated a map of the IBD-associated immune cell network by single-cell analyses of healthy and IBD patient samples. In my postdoctoral work, I have developed an Air Liquid Interphase (ALI) intestinal organoid platform derived from human samples that supports tissue-resident immune cells.In this project, I aim to identify cellular and molecular networks driving IBD by diagnostic and intervention studies in intestinal ALI organoids.  For this purpose, I will: 1) Validate ALI intestinal organoids as accurate ex vivo model by analyzing their immune cell composition and functionality in spatial context; and 2) aligning this with the in vivo situation by data mining of public single-cell RNA-seq of inflamed intestines. 3) Integrate datasets generated in 1-2) to reveal cellular and molecular immune cell interactions associated with IBD; and 4) Implicate interactions identified under 3) in driving IBD by molecularly targeted interventions in ALI organoids. The proposed work will take place at host institute Leiden Univ. Medical Center, with a 4-month secondment phase at Technical Univ. Delft.This project is expected to deliver insight into immunologica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Production of an innovative Lightweight Ceramic Brick, with increase noise absorption capabilities and heat insulation' in the context of a Seventh Framework call.

assistant: **Objectives**

The overall technological aim is to develop a mould-brick acoustic solution based on noise absorption and insulation due material density and porosity that will at least increase levels in 6 dB in performance but at a 20% lower weight and will avoid or minimize noise flanking. The acoustic insulation and absorption of the brick will be achieved by developing the concept of layers oand forms in the brick. The layer concept consists in developing different layers with different density and porosity across the brick section, for achieving a better noise insulation and absorption, but also thermal. The porous size and placement will increase the noise absorption while the increase density in section will allow us to keep or increase the noiise insulation. The internal forms will benefit for increase the reflection and absorption and the ecternal form, will avoid or minimize the flanking by creating a male-female join. The performance of the acoustiv brick will exceed current solutions The specififv technological objectives are to produce a mould-brick manufacturing solution that: 1.Will create a brick consisting in different sections where density and porosity are different for increasing insulation levels 2.The insulation level will be 6dB higher than current solution but with a 20% less weight 3.Will avoid or minimize noise flanking due to its external form 4.Will consume less energy and resources due to the manufacturing enhances achieved in the project 5.Design testing software to predict solution behaviour, once its form and characteristics have been decided, in order to decrease costs during mould and a brick making
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'New Challenges in Set-Valued Numerical Analysis'.

assistant: **Objectives**

This research project aims at the development of a radically new systematic approach to the field of set-valued numerical analysis. It is based on recent breakthrough results on the representation of sets as functions in a Banach space, and will allow the design of high performance numerical schemes for problems in dynamical systems and control theory, which cannot be solved efficiently within the traditional framework.The last two decades have witnessed the successful development of grid-cell discretisations for the computation of characteristic sets of dynamical and control systems (attractors, reachable sets of control systems, etc.). The most popular software package based on this discretization is the computer program GAIO, which is used throughout the academic community and by institutions such as NASA.Though grid-cell methods have reached a high degree of maturity, their computational complexity is very high, and they suffer massively from the curse of dimensionality. Since grid-cell discretisation possesses little structure, these schemes can at best be first-order convergent.Therefore, this proposal aims at developing an alternative technique for the representation, analysis and numerical treatment of subsets of the Euclidean space. Instead of interpreting sets as collections of points without any further structure, sets will be grouped into set spaces that can be embedded into appropriate Banach spaces by means of a generalised support function. In this setting, sets can be handled by higher-order numerical methods such as Newton's scheme instead of first-order grid-cell methods.The exploration of further properties of these set spaces, the development of efficient tools for the approximation of sets and the application to problems in dynamical systems and con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of a global network for the real-time detection of failures and extreme events in natural disasters' (MELINA) targeting Seventh Framework.

assistant: **Abstract**

The proposed MELINA project aims at bringing together experts in geodetic satellite positioning for precise earth-surface deformation monitoring related to natural disasters, like earthquakes, landslides, rockfalls, etc. The main objective is to develop statistical tools for early detection of failures or progressive secular changes of very small magnitude in geodetic monitoring signals, in a timely, precise, uniform and reliable manner to support early warnings. To accomplish this task this international consortium will collaborate to a) integrate existing and future global satellite navigation systems (e.g., GPS, Glonass, BeiDou, Galileo) established at different world locations and monitoring earth surface deformation, b) advance mathematical and physical modelling for developing these statistical tools, and c) validate the performance of newly developed algorithms for abrupt change detection in geodetic monitoring signals.This exchange program will enhance each partner’s skills on a common and internationally-adopted basis to issue warnings when monitoring deformation of earth surface using global positioning satellite systems. This networking activity will be achieved by sharing knowledge, enhancing research training, and finally acquiring new techniques through algorithm development for quality control and deformation monitoring of signals produced by satellite positioning.""