RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Revolutionary rib-welding system for the worldwide first fully automated production of large, high quality, on-site welded tanks, bringing considerable cost savings to drinking water applications' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

LIPP GmbH, based in Tannhausen in the south of Germany, is one of the leading tank manufacturers in Europe, having been in existence since the 1950’s. In the past decades, Lipp has patented over 170 different manufacturing, material and tank design technologies and is an innovative highly awarded (Rudolf-Diesel-Medaille) SME. Altogether, over 50,000 tanks and containers have been constructed globally with the internationally marketed and licenced LIPP Double-Seam Technology. Recent R&D has applied the experiences of the Double-Seam to develop a revolutionary, automated Rib-Welding System for the on-site erection of novel, flexible and large scale welded stainless steel tanks at superior quality and lower costs. An investment of € 2 million has led to the completion of 2 prototypes. Significant material and manufacturing cost reductions (up to – 45%) are possible due to the efficient, fast and automated on-site welding units. Cost reductions will lead to a unique selling position for applications in water and food industries, especially in drinking water storage. The water and food industries mainly use such types of tanks because of the strict hygienic regulations in this sector. Conservative estimations of the drinking water market allow yearly revenue of € 13 million in a billion Euro market segment after successful introduction of the technology in the next five years. The new technology is a central element for the future growth of the LIPP company. Additionally, the LIPP Rib-Welding System can be applied to conventional welded steel tanks and opens the market for large oil and pharmaceutical/chemical tank applications. This will strongly enhance profitability and growth performance of LIPP by transferring a substantially improved technology and existing knowledge i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Understanding how different condensin activities regulate mitotic chromosome folding in human cells' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In human cells, the SMC complex condensin plays a significant and essential role in chromosome condensation, but there is conflicting data. Studies from other groups have suggested that the loop extruding activity of condensin is important for chromosome folding, but a study from my host lab suggested that loop extrusion (LE) alone is not able to package chromosomes. Using molecular biology experiments and polymer simulations they hypothesized that condensin has an additional bridging induced phase separation (BIPS) activity that is required for correct chromosome folding. In its absence, chromosomes are not fully compacted leading to chromosome instability.I will collaborate closely with polymer physicists in Edinburgh to interpret experimental data and to understand how different condensin activities are necessary for chromosome folding. Together, we expect to provide a new model of condensin molecular functions based on experiments in vivo analyzed together with simulations of mitotic chromosomes. Deviations between simulations and experiments will be used to identify gaps in our knowledge leading to new hypothesis generation.My aim is to investigate how different condensin activities (BIPS vs LE) regulate mitotic chromosome folding. To achieve this I have the following objectives:(i) Use an in silico model of condensin-mediated chromatin folding with diverse levels of LE and BIPS to develop models of chromosome folding and generate testable hypotheses and predictions.(ii) In human cells replace endogenous condensin components with already identified separation of function mutants to alter the balance between BIPS and LE activities and assess their role in chromosome folding.(iii) Explore how different mutations affect condensin binding and clustering on mitotic chro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SYSTEMIC TRANSFORMATION TOWARDS LOCAL AND REGIONAL CLIMATE RESILIENCE' (SMARTER).

assistant: **Concept**

Different climate risks are considered in climate adaptation strategies at the local, regional, and national level, as well as in the EU Adaptation to Climate Change Mission. The interdependencies between risks are also increasingly considered. However, achievement of full climate resilience requires going much further: considering interdependencies across sectors, spatial scales, governance levels and knowledge domains. The systemic challenges behind the risks are to be addressed, creating synergies which increase public support and make adaptation more affordable. Recognising these systemic challenges also requires standardisation to optimise upscaling and replication. The ambition of SMARTER is to support a transformative change needed for systemic climate adaption by addressing these cross-sectoral interdependencies. To achieve this, we set up 10 Climate Adaptation Labs, spread over Europe, in which we develop and demonstrate a systemic approach, including supporting tools at the local and regional scale. The Labs host 5 demonstration pilots and 7 replication pilots, which have already identified different cross-sectoral domains that relate to their contextual climate adaptation challenges. Each of them contributes to a portfolio of solutions and guidelines for systemic climate adaptation. Solutions are built through participatory co-design and demonstration, combined with systemic foresighting. Key outcomes include an integrated toolbox for systemic climate adaption, a harmonised portfolio of demonstrated solutions and evaluation framework, replication strategies and road maps for climate adaptation with consideration for the financial and administrative aspects. SMARTER will directly impact regions and communities through the transformative solutions demonstrated,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Matching soil biodiversity with global biogeochemical cycles' (SOBIGLOBIC).

assistant: **Innovation**

About 80% of the global terrestrial C pool is located in soils, and over 50% of the CO2 evolved from soils is due to respiration of heterotrophic biota involved in net secondary production. Consequently, the flux of C from belowground to the atmosphere through respiration is >10 times larger than anthropogenic emissions, and changes in soil respiration could significantly increase or mitigate current increases of CO2. Predictions derived from global scale CO2 models differ significantly, with the anticipated amount of CO2 in the atmosphere varying by up to 200 ppm at the end of this century. Global scale CO2 predictive models concatenate sets of models that describe biophysical processes and climate. Global circulation models are coupled with soil organic matter (SOM) decomposition models by interpolating dynamic global vegetation models, and a great deal of the variability in final predictions is due to uncertainties in the terrestrial C cycle. Improving SOM mineralization models is essential to progress towards more precise global predictions and, to achieve this, soil biota must be explicitly represented in SOM models. Soil microbes carry out most of the SOM transformation, but larger soil animals are crucial as regulators of the process and must be considered. The general objective of this project is to model effects of soil food webs on C and N mineralization and on gas emissions from soil, including effects of soil fauna (from a soil food web perspective), and to couple this model with the SOM submodel of the DYANET model. The project will be held at the Colorado State University under Dr. D.H. Wall for soil biodiversity and Drs. JH Moore and W. Parton for soil food web and SOM modeling. The EU has recognized a severe knowledge gap on soil biodiversity functions,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cardiac Death and Regeneration' to be submitted under Seventh Framework.

assistant: **Abstract**

Cardiac muscle death, unmatched by muscle cell creation, is the hallmark of acute myocardial infarction and chronic cardiomyopathies. The notion of heart failure as a muscle-cell deficiency disease has driven interest worldwide in ways to increase heart muscle cell number, by over-riding cell cycle constraints, suppressing cell death, or, most directly, cell grafting. Using stem cell antigen-1, we previously identified telomerase-expressing cells in adult mouse myocardium, which have salutary properties for bona fide cardiac regeneration. Here, we seek to address systematically the mechanisms for long-term self-renewal in Sca-1+ adult cardiac progenitor cells and in the smaller  side population  fraction, which is clonogenic and expresses telomerase at even higher levels. Specifically, we propose to study the roles of telomerase and of the telomere-capping protein, TRF2. Aim 1, Determine the properties of adult cardiac progenitor cells in mice that lack the RNA component of telomerase (TERC). Aim 2, Determine the properties of adult cardiac progenitor cells in mice that lack the catalytic component (TERT). To distinguish between effects of these two gene products themselves versus those that depend on cumulative telomere dysfunction, G2- and G5-null mice will be compared.  Aim 3, Determine the properties of adult cardiac muscle and adult cardiac progenitor cells that lack the telomere-capping protein TRF2. Aim 4, Test the prediction that forced expression of TERT and TRF2 can augment cardiac muscle engraftment in vivo and enhance the clonal derivation of adult cardiac progenitor cells in vitro, without adversely affecting the cells  differentiation potential. Work proposed in Aims 1-3 would provide indispensable fundamental information about the function of endogenous t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High temperature reactor, nuclear, physics, waste and fuel cycle studies' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The nuclear physics codes for Low-Enriched (LEU) HTR fuel can be verified and adjusted with measurements at the test HTR reactors in Japan (HTTR) and in China (HTR-10).Additional information will be available from the critical facility PROTEUS in Switzerland. The core analyses with different codes will allow determining temperature coefficients and control rod worth for block and pebble bed type HTR with LEU fuel for safety evaluation and design. Plutonium extracted fro m spent LWR MOX is considered as an attractive HTR- fuel cycle to reduce the growing stockpiles of civil Plutonium.HTR core analysis will be made for this symbiosis of LWR and HTR. Special treatments for purification of contaminated carbonaceous material from the core structures are intended to improve the disposal or re-use. Data for long-term geochemical modelling of directly disposed spent HTR fuel will be generated by leaching tests on the matrix, coating and kernels of fuel elements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ground-BrEAking Electroporation-based inTervention for Atrial Fibrillation treatment (BEAT AF)' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Atrial fibrillation (AF), the most common arrhythmia, accounts for 1/3rd of Cardiovascular expenses, with over 10 millions affected in Europe. In addition to significant impact on quality of life, AF exposes patients to stroke, heart failure, dementia and death. AF is the most commonly ablated arrhythmia. The Pulmonary Vein Isolation (PVI) is the cornerstone of AF ablation, preventing recurrences, especially in patients with paroxysmal AF. Catheter ablation of AF uses either radio-frequency (RF) or cryothermal (cryo) energy. Common to these thermal energy sources is their reliance on time-dependent conductive heating/cooling and the fact that these modalities ablate all tissue types indiscriminately. The ablation procedure remains long, requires skills and expertise, and has a limited success rate, mostly because of non-durable lesions after PVI implying frequent redo procedures. And these energies are associated with rare but severe complications due to their thermal nature. The goal of BEAT AF is to disrupt AF ablation by achieving durable PVI with permanent, coalescent and transmural ablation lesions using Pulsed Electric Field (PEF) energy.  PEF is non-thermal and creates nanoscale pores in cell membranes. Cardiac cells are highly sensitive to PEF unlike phrenic and oesophageal cells. BEAT AF aims to demonstrate that PEF ablation is faster, more effective and safer (tissue selectivity) than RF or cryo ablation. For this purpose, two distinct randomized clinical trials will be conducted: 1) to provide first comparative evidence of the superiority of PEF over RF on the rate of 1-year recurrence for paroxysmal AF, and 2) to provide first evidence of potential efficacy of PEF on the rate of 1-year clinical recurrence for persistent AF.  The BEAT AF consortium gathers 9
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Nonlinear Optical and Electrical Phenomena in Topological Semimetals' (NonlinearTopo) under Horizon 2020.

assistant: **Objectives**

In the past decade, the band-structure topology and related topological materials have been intensively studied mostly by revealing their unique surface states. The current proposal sets a new paradigm by focusing on nonlinear optical phenomena in topological semimetals (TSMs). I aim to investigate the photocurrent and second-harmonic generation, as well as to discover novel nonlinear effects. The strength of TSMs lies in the fact that the giant Berry curvature in their band-crossing regions (e.g., Weyl points) can strongly boost these nonlinear effects, such as inducing a colossal photocurrent. Current understanding of the photocurrent is based on a model that considers the two-band transition within a Weyl cone. In the field of nonlinear optics, however, it is known that the photocurrent largely comes from three-band virtual transitions. Unfortunately, the nonlinear optics theory cannot be simply applied to TSMs due to the unphysical divergence of the photocurrent at band-crossing points. Therefore, I propose to bring the concept of three-band transitions to TSMs by reformulating the photocurrent theory framework. The new methodology represents the challenging and ground-breaking nature of the current proposal. Beyond the optical excitation, I further propose to explore exotic nonlinear electric and thermoelectric phenomena at the zero-frequency limit. I aim to build up a diagnostic tool that explores the nonlinear phenomena in a vast number of real TSM materials and directly probe the bulk topology by investigating their nonlinear properties. For example, my recent results have exposed a new group of Weyl points in a well-known Weyl semimetal by analysing the photocurrent distribution in its band structure. External perturbations can sensitively modify the TSM band s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Biochemical and genetic characterisation of the p38 MAPK cascade that mediates arsenite signalling in human osteosarcoma cells' under Sixth Framework.

assistant: **Concept**

Arsenic contamination from both natural and industrial sources is a significant public health problem. Arsenite, the trivalent form of arsenic, is a strong tumour promoter associated with multiple types of cancer. Paradoxically, arsenite is also effective in treating acute promyelocytic leukemia.The exact mechanism of arsenite activity is still unclear; however, it strongly induces three major intracellular signalling pathways, the ERK, SAPK and p38 MARK cascades, that control gene expression via the transcriptional regulator AP-1.Within the ERK and SAPK cascades, specificity is conferred by organisation into distinguishable signalling modules assembled into large molecular complexes. Our recent data indicate that, in human osteosarcoma cells, the p38 pathway also contains different signalling modules activated selectively by arsenite and the antibiotic anisomycin.This project will- characterise the molecular organisation of the p38 cascade activated by arsenite in cancer-derived cell lines and- use the novel genetic technique of RNA interference to selectively inactivate arsenite-indeed intracellular signalling.We will use biochemistry and molecular biology techniques to analyse the molecular assemblies that mediate this selectivity within the p38 cascade. To address the role of the p38 cascade in the cellular response to arsenite, components of this cascade will be down-regulated using RNA interference.These siRNAs will target different isoforms óf p38 and its activating kinases MKKs 3, 3b and 6. We will assess the effect of their elimination on the induction of genes encoding components of AP-1, such as c-fos, c-jun, andjunB.Taken together, these two approaches will further our understanding of the mechanism by which arsenite can exert both carcinogenic and therapeut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Start Learning in 3D-Worlds with Powerful Memo-Techniques' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

There is a high percentage of early leavers (11% among EU-28) and drop-outs among university students (31% among OECD countries). Students fail mainly due to demotivation and poor instructional materials being more eager to search for a job below their qualifications. One of the goals of the Europe 2020 strategy is to reach at least 40% of European adults (30-34 – year old) completing tertiary education (above school age) because today only 26% of the European workforce has this level despite the fact 35% of all EU job positions require this or higher level of education. Students are challenged with long-term memory and despite their efforts to retain information 80% of it is gradually washed away shortly after the exams increasing learning demotivation. Current digital tools are not properly supporting students in this challenge, and given that >75% of the curricular content of many disciplines are based on memorization, this is a priority challenge. Memorix app is our VR and AI powered mobile and web application that integrates emotional triggers and gamification elements helping students to well-stablish their long-term memory. To effectively engage students, Memorix app uses a co-creation approach where the student itself creates unique memory journeys in virtual 3D worlds, making the learning process intrinsically motivating. None of the current solution in the market offer a similar approach: co-creation in the front end and intelligence in the back end. Memorix app is a novel product into the Educational Technology market which exceeded €15.16 B globally by 2017 and is rapidly growing (18.3%/year). Applying a B2C business model, with Memorix app we estimate to reach 94,000 university students as subscribers by 2026 for a total cumulative profit of €24.9 million (