RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The first smartphone-connected medical device for a secure remote diagnosis of ears, nose, eyes and skin conditions' under Horizon 2020.

assistant: **Concept**

The Euro Health Consumer Index (EHCI) 2016 study on healthcare systems in 35 European countries has shown that gatekeeping to access specialists means increased waiting time and therefore high resource consumption, such as administrative personnel and infrastructure costs. Waiting times for specialist care are found predominately in systems requiring referral from primary care or general practice. Services such as otolaryngology, ophthalmology, dermatology may routinely be done from a patient’s location or from primary care sites to specialists to avoid waiting times and final diagnosis. Although telemedicine is an extremely attractive solution to bring healthcare closer to the patient, most of the current telemedicine technologies focus only on providing video or text communication tools. This misses a significant part of the consultation: the clinical examination and the taking of the patient history. We at Cupris Ltd have found a unique solution to enable the remote diagnosis for hearing, ophtalmology and dermatology diseases, the management of patient conditions and the taking of patient history. CUPRIS consists of a secure communication system (app and web-platform) for healthcare consultations that enables remote clinical assessment (including examination) of patients from any location with the help of smartphone-connected medical devices. Cupris smartphone-connected devices provide enhanced functionality and security over those currently used for a much lower cost (from 60% - 550% more price competitive). Among its advantages, it will help health systems to reduce waiting lists (up to 27% of the consultations) and associated costs; and it will help the patient to receive diagnosis in a shorter timeframe (even near to real time), without being physically present w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Energy networks in sustainable cities' (POLYCITY).

assistant: **Concept**

The POLYCITY proposal focuses on large-scale urban developments where living and working areas are integrated to result in sustainable city quarters with short distances and low transport energy consumption. The project treats different aspects of urban conversion: new constructions on sites with little development at the city edges of Barcelona, conversion of an old city quarter in Torino and a mixture of rehabilitation and new construction on a large military ground near Stuttgart.Only large urban conversion sites were chosen to obtain the maximum impact: the rehabilitation project in Torino covers 87500 m2 in an old quarter, where a high social impact is expected through the implementation of efficient district heating. The urban conversion project in Stuttgart covers 178000 m2 of newly constructed surface area for 10000 people and provides very high building standards combined with biomass co-generation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European integrated info-box system for improved food safety and logistics' to be submitted under Fifth Framework.

assistant: **Abstract**

Because of several meat scandals, consumer trust in meat products is severely damaged. Food safety and chain reliability will have to be increased. That is why the objective of the Info-Box System (IBoS) is to improve logistics and to increase transparency of information in the logistic chain of perishable goods such as meat products. This is achieved by using a new transport box, state-of-the-art RF transponder technology and a new integrated, Internet accessible Supply Chain Management System. As this innovation requires the support of all nodes and high standardization, extensive field trials are needed with 15000 boxes to prove and optimise the benefits of the system. In the IBoS Trial the necessary equipment, soft- and hardware will be assessed, installed at several nodes, trialed, optimised, trialed again and evaluated. The experiences will be disseminated and lead to introduction of the Info-Box System in the market, as well as spin-off products.DESCRIPTION OF WORKThe work consists of all needed activities to set up, perform, monitor and assess 2 test trials. Each trial will involve 15.000 IBoS boxes, covering a period of 3 months each. The work has been divided in 6 workpackages and a supportive 7th workpackage for project management: WP 1: Assessment and selection of transponder equipment, software and hardware components. WF 2: Installation of equipment and providing access to open SCMS at each involved node in the logistic chain. Setting up the Supply Chain Management System. WP 3: First trial, involving meat producers and 15.000 IBoS boxes during a 3-month trial period. Assessing first trial, results and conclusions. WP 4: Optimisation equipment, hardware and software and SCMS according to results of first trial. WP 5: Second trial with complete logistics ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of CD63 in lysosomal degradation of insulin granules in pancreatic beta cells in T2D diabetes' (INSULYSOSOME).

assistant: **Concept**

The pancreatic β cell harbors an exemplary nutrient sensing machinery that is coupled to secretion of insulin. While mechanisms governing regulation of insulin secretion in response to nutrients were widely investigated, little is known about how nutrients impact on other basic cellular processes such as insulin granule turnover, autophagy and cellular growth, deregulation of all of which have been demonstrated to be involved in β cell failure in type 2 diabetes (T2D). T2D represents a major health burden accounting for a large part of exploding health costs world-wide. Restoring normal weight through exercise and decreased food consumption in principle is straight-forward to mitigate metabolic disturbances. However, changing the sedentary life style is very challenging for obese subjects and that at a late disease stage, β cell failure becomes irreversible. There is an emerging endeavor of the pharmaceutical industry to develop strategies targeting the β cell that go beyond improving insulin secretion. A prevailing concept in cell biology is that enhanced degradation of cellular components through autophagy can counteract energy depletion caused by shortage of environmental nutrients. My host laboratory recently discovered that β cells employ a very distinct and so far unknown mechanism to adapt to nutrient depletion. β cells induce specific degradation of newly formed insulin granules through lysosomes and suppress autophagy upon nutrient withdrawal. Insulin granule degradation allows for generation of intracellular nutrients and in the same time avoids release of these granules. Their preliminary results suggest that lysosomal insulin granule degradation is dramatically enhanced in β cells of diabetic islets from mice and humans. This increase is accompanied by a dro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'HyGuide' (HYGUIDE) targeting Seventh Framework.

assistant: **Abstract**

The overall goal of the call “SP1-JTI-FCH.2009.5.5 LIFE CYCLE ASSESSMENT (LCA)” is to develop a specific guidance document for application to hydrogen and fuel cell technologies and related training material with courses for practitioners in industry and research. This is to be based on and in line with the International Reference Life Cycle Data System (ILCD) Handbook, co-developed by the European Commission's JRC-IES.Our concept for this guidance document relates back to an international standardized procedure: the Environmental Product Declaration (EPD) System (ISO 14025), providing consistent information using common program and product category rules (PCR). HyGuide will be similar to a PCR.To further improve acceptance and applicability, a strong and active involvement of all relevant stakeholders is foreseen.To ensure compatibility with related tools in policy and industry context, the HyGuide will be prepared in line with the ILCD Handbook, in advice by the EC JRC-IES' “European Platform on LCA”.The HyGuide will equally be coordinated with the consortium of the JTI call “Technology Monitoring and Assessment”.The balanced, multidisciplinary project consortium features specifically experienced research, consultancy and industry partners and the EC: PE INT, USTUTT, KIT-G, the JRC-IE and the European Hydrogen Association (EHA). The EHA's key role is to involve industry members and support dissemination of the results to a broad audience (supporting action).The expected outcomes of HyGuide include:• A PCR-type guidance document - based on the ILCD handbook - that is scientifically sound, industry accepted and quality assured (reviewed),• LCA study reporting templates, tailor-made to hydrogen and fuel cell technologies,• Broad dissemination among LCA practitioners and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A game changing technology to revolutionise donor organ preservation and enlarge the pool of organs for transplantation' under Horizon Europe.

assistant: **Concept**

There are over 150,000 people on waiting lists for organ transplantation in Europe and the US today. Current transplantations cover less than 20% of the actual need, estimated at 1M organs by the WHO, due to the shortage of available transplantable organs. Predominantly used organ preservation methods fail at extending the pool of available organs. Perfusion at body temperature is the optimal organ preservation technology and it can expand the donor organ pool as it enables viability assessment and revitalisation before transplant. However, it is still underutilized in the clinical practice due to the requirement of blood, high costs and complexity of use, which makes it hardly scalable. Vivalyx has invented a game changing technology that unlocks the benefits of warm perfusion. This is Omnisol, a fully synthetic blood substitute solution that outperforms blood 3x in terms of organ viability and function during preservation. Vivalyx technology enables 3-4x organ pool expansion due to the organ resuscitation capabilities. Vivalyx was founded in 2022 by a group of scientists and medtech entrepreneurs with the vision of enabling all patients on transplant waiting lists to receive the organ they need. Through the EIC project Vivalyx will bring body temperature perfusion to the market, making this key technique of organ preservation scalable for the first time, creating tangible benefits for patients on transplant waiting lists.


**Keywords:** organ preservation, normothermic machine perfusion, warm perfusion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Scalable automation for flexible production systems' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The main objective of the ScalABLE 4.0 project is the development and demonstration of an open scalable production system framework (OSPS) that can be used efficiently and effectively to visualize, virtualize, construct, control, maintain and optimize production lines. The OSPS aims to provides this through a) a tight integration of the enterprise information systems with transformable  automation equipment paired up with b) the necessary open APIs for optimized solutions on all hierarchy levels. The development of this OSPS framework is an answer to the growing demand of manufacturing companies to have efficient tools enabling them to optimize the organization of their production lines ‘on the fly’ and that have approached members of the consortium over the past few years. Two of these companies (PSA and Simoldes Plasticos) are part of the consortium and are at the center of this proposal. To assure full generality of the framework, they have defined two highly challenging use-cases against which the OSPS will be verified, tested and demonstrated on site and under industrial conditions.This will be achieved by a tight integration between (a) advanced robots production devices , (b) a highly advanced model for the plant, (c)  decision support technologies (d) advanced networked interfaces and plug and produce technologies.  The expected economic impact is considerable and easily measurable in the demonstrator: by dynamically scaling the production resources to the current production volume and variant, both end-users will demonstrate substantial savings generated by the adaptable production capacity. For instance, the pilot engine production plant at PSA would be able to save approx 10 M€ just for the ramp-up of a single line.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'FREE the MIND: the neurocognitive determinants of intentional decision' (FREEMIND) targeting Horizon 2020.

assistant: **Abstract**

Acting based on intention is a fundamental ability to our lives. Apple or orange, cash or card: we constantly make intentional decisions to fulfil our desires, even when the options have no explicit difference in their rewards. Recently, I and others have offered the first evidence to support that intentional decision and externally guided decision share similar computational principles. However, how the brain implements these principles for intentional decision remains unknown. This project aims to establish a multilevel understanding of intentional decision, spanning from neurons to brain networks to behaviour, through a powerful combination of novel paradigms, cutting-edge brain imaging, and innovative methods. Central to my approach is formal computational modelling, allowing me to establish a quantitative link between data and theory at multiple levels of abstraction. Subproject 1 will ask which brain regions encode intentional information, when intentional processes occur, and how neurochemical concentration influences intentional decision. Subproject 2 will focus on theoretically predicted changes in intentional decision under behavioural and neural interventions. I will use brain imaging and brain stimulation to test the flexibility of intentional decision within individuals. Subproject 3 will launch the largest study to date on intentional decision. I will characterize individual differences in intentional decision from 2,000 representative samples. I will then investigate, with high statistical power, the contributions of neurochemistry and brain microstructure to individual differences in intentional decision. This project premises to establish the first neurobiological theory of intentional behaviour, and provide mechanistic understanding of its changes with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Native-Born Youth of African Immigrants and Cardiovascular Risk:  A Mixed Methods Study' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Cardiovascular risk factors (CR) are the leading cause of morbidity and mortality in developed countries.  By adolescence, CR of diet, exercise, blood pressure, body mass index, and smoking already are predictive of adulthood morbidity.  Although genetics play a part in CR, health behaviors are the major contributors.  Health status and service use differ between ethnic/racial groups (including immigrants) and the dominant population, but is this true of the influences on health behaviors?  Europe and Israel are common destinations for international migrants from the least developed African nations.  Capitalizing on a mixed-methods design and Community Based Participatory Research approach, this study will address ethnic/racial disparities in health care access by examining the influences of all four Bioecological Model's domains on cardiovascular risk factors in youth, comparing native-born youth of African immigrants (Ethiopians) to veteran Israelis. Qualitative interviews from 45 stakeholders and youth will be used to identify unique influences not found in existing literature.  Informed by the interviews, quantitative surveys with new and established instruments will measure the impact of the four domain influences of the Model on CR. The surveys will be administered in three areas of Israel to a sample (n=600) comprised of two groups of 15-18 year old native-born youth, one born to African immigrants and the other to veteran Israeli parents.  Using a variety of statistical techniques, the impact of each domain will be measured for all youth and each group. This study represents the first attempt to integrate the full range of domains on health behaviors affecting CR in youth, and disaggregate them for dominant society and second generation immigrant youth.  Not onl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Exploiting the wheat genome to optimise water use in Mediterranean ecosystems'.

assistant: **Innovation**

Water is a major determinant of yield for farming wheat in the Mediterranean basin. Wheat is mainly grown under rainfed conditions often characterized by relatively low and uncertain rainfall. The projected change in global climate towards even drier con ditions in the Mediterranean basin will further compound this problem. Durum wheat farming faces continuous fluctuations in production and bread wheat is imported, to a relatively large extent, in many countries. Therefore, there is an urgent economic n eed to improve the water use and water use efficiency in wheat production. This proposal aims to idenitfy crop traits and genetic ideotypes, in wheat, that impart stable yield under Mediterranean drought conditions. This shall be realised by using an int egrated approach combining genomics, quantitative genetics and crop physiology. We shall evaluate a range of different genotypes of durum and bread wheat for WUE, integrative morpho-physiological traits, yield and qualtiy under Mediterranean field condit ions ranging in water availability. We shall select best durum and bread wheat lines evaluated under field conditions for integration into breeding programmes. We shall detect QTLs from a durum mapping population grown under Mediterranean field condition s and new molecular markers. We will design and build a new custom wheat chip for the study of gene expression in select genotypes evaluated under field conditions in the Mediterranean. We shall develop the experience and knowledge of young scientists fro m WANA countries in the latest molecular and physiological techniques. We shall conduct a socio-economic study on wheat farming and new technology in Mediterranean countries. The project fully complies with the main and strategic objectives of this call: Development of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Metabolic and Genetic Regulation of Ageing'.

assistant: **Concept**

Ageing is a complex physiological process that affects almost all species, including humans. Despite its importance for all of us, the biology of ageing is insufficiently understood. To uncover the molecular underpinnings of ageing, I propose an interdisciplinary research program that will identify and investigate metabolic and genetic regulators of ageing.Progressive loss of cellular homeostasis causes ageing and an age-associated decline in protein quality control has been implicated in numerous diseases, including neurodegeneration. Seeking for ways to improve protein quality, I have identified a novel longevity pathway in Caenorhabditis elegans. In a forward genetic screen, I found a link between metabolites in the hexosamine pathway and cellular protein quality control. Hexosamine pathway activation extends C. elegans lifespan, suggesting modulation of ageing by endogenous molecules.In a first step, I will explore the mechanism by which hexosamine metabolites improve protein quality control in mammals, using cultured mammalian cells and a mouse model for neurodegeneration. Preliminary data show that hexosamine pathway metabolites enhance proteolytic capacity in cells and reduce protein aggregation, suggesting conservation. Second, I will investigate molecular mechanisms that activate the hexosamine pathway to promote protein homeostasis and counter ageing. Third, I will perform a direct forward genetic screen for modulators of ageing in C. elegans. For the first time, mutagenesis and next generation sequencing can be paired in forward genetic screens to interrogate the whole genome for lifespan-extending mutations in a truly unbiased manner. This innovative approach has the potential to reveal novel modulators of the ageing process.Taken together, this work aims to