RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Optimum Surface Condition for Fatigue Sensitive Components Operating at Elevated Temperature'.

assistant: **Concept**

Objectives and content This project is the result of a concerted European aero-engine industry effort; it also includes a partner representing an end user of aero-engines as well as a developer of surface treatment processes and a research organisation specialising in testing and understanding material behaviour. This 48 month programme will provide a methodology for specifying the optimum surface condition for fatigue sensitive components operating in aero-engines and thus lead to lower life cycle costs for the engine, increased reliability and improved safety. It will contribute to a better competitive position for the European aero-engine industry. Gas turbine engines require materials to be operated at the limits of stress and temperature to achieve a competitive engine performance. Rotating components, such as discs, are critical to the safety of the aircraft as failure leads to uncontained fragments with high kinetic energy and elevated temperature which can impact and hazard the airframe and controls. The vast majority of fatigue failures are surface originated, a combination of both the material and the surface condition. While new high strength clean" materials, developed for such parts, do give better basic material fatigue performance as well as increased temperature capability, in order to realise these advantages it is essential to achieve the optimum surface condition of these critical components. An optimum surface condition must be tolerant of surface damage such as scratches and dents received during handling as well as offering a sufficient advantage in the undamaged state. The main objectives of this proposal are: - A comprehensive database of specimen results showing the performance of both current and near term future surface conditions on both a ni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Evaluation of early indicators for sensitisation to nickel, cobalt and chromium. Methods for risk assessment.' under Fourth Framework.

assistant: **Concept**

The objectives of this project improve our knowledge of nickel, cobalt and chromium allergies in the general population through: a. Evaluation of one or more indicators of exposure for each metal. b. Development of a strengthened scientific basis for risk assessment. c. Development of screening methods for risk assessment.Background  Contact sensitisation to the metals nickel, cobalt and chromium (as chromate) is common in the general  population. Sensitisation is often caused by skin contact with objects containing these metals. A recent study  showed that 11% of the females of a Danish population were allergic to nickel. Smaller, but significant  fractions of the population reacted to cobalt and chromate. The frequency may be higher in other EU countries.  Sensitised individuals often get skin reactions (contact dermatitis), e.g. hand eczema, when exposed to the  metals. The consequences of eczema are often long lasting sick leave or permanent disability. Thus metal  contact dermatitis also has considerable socio-economic consequences. Methods for prediction of significant  metal exposure and effective screening methods to be used for risk assessment are highly needed.  Overview of the project work and expected achievements  The project is a multi-disciplinary collaboration aiming at elucidating molecular and cellular responses resulting  from exposure to the metals. The issues include:  *Clinical studies for establishment of threshold concentrations of the metals for reaction in metal sensitised individuals as well as concentration of the metals in blood, urine and skin.  *Development of in vitro-assay for early detection of sensitisation and for risk assessment of the general population.  *Studies of responses on cellular level to metal exposure, including uptake of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Climate control on continental erosion: a stochastic modelling approach' in the context of a Fifth Framework call.

assistant: **Objectives**

Climate variability and change are first order controls on continental erosion. In order to study the erosional and topographic response of river catchments to climate forcing, a stochastic surface process model will be driven by high-resolution input from general circulation and regional climate models. Emphasizing the role of extreme events, the impact of known and modelled magnitude-frequency distributions of meteorological events upon sediment routing systems will be constrained. The transient dynamics of climatically perturbed landscapes will be investigated with special attention for the dependency of response time upon erosion-transport processes and catchments size. Results will be used to constrain an investigation of the erosional response to climate change. Time series of weather data from global and regional climate models will be used to drive simulations-of the Late Cenozoic evolution of sediment fluxes from tectonically quiescent and active regions represented by Europe and Taiwan, respectively. Simulation output will be calibrated against known fluxes from present catchments and the stratigraphic and geomorphic records. It is expected that by using the output from climate models to drive a state-of-the-art surface process model important new insights will be gained into the role of climate change in erosional landscape evolution. This study will aid the prediction of future trends in erosion in Europe in the context of changed land use and weather patterns.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Preparation of a proposal for stock assessment of some elasmobranch fishes in european waters.' to be submitted under Fourth Framework.

assistant: **Abstract**

The main objective of this concerted action is to organise two meetings of three days each in order to formulate a new research proposal, which describes the steps required to obtain and compile the data with which to carry out stock assessments of a limited number of elasmobranch species in European waters.A recent initiative taken by the ICES Study Group Elasmobranch Fishes, to attempt stock assessments, has been hindered by lack of appropriate data. Not because there are no data, but because data collection and analysis is not well co-ordinated on a European basis. Basic biological data and data on changes in abundance of elasmobranchs, although collected by many institutes, are not readily available, often being pooled with data on several species or left unanalysed. The data are often sparse, even for those species, which are regularly landed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Spin transport and dynamics in silicon-germanium islands' to be submitted under Seventh Framework.

assistant: **Abstract**

This project is centered on spin-dependent electronic transport and spin dynamics in self-assembled SiGe islands, directed at the development of semiconductor spintronic devices. In spite of its promising properties, SiGe remains a largely unexplored system for this purpose. The proposed project is further motivated and supported by an existing experience in the host group, which has recently succeeded in the realization of the first electronic devices based on individual SiGe quantum dots (QDs). Experimental effort will be first focused on the implementation of ferromagnetic (FM) contacts to the SiGe islands. Subsequently, low-temperature tunnel magnetoresistance (TMR) measurements will be performed as a function of the gate voltage and tunnel-coupling. The TMR response will provide important information concerning spin-injection efficiency and the impact of the Coulomb blockade phenomenon. Moreover, the effect of electric fields on the TMR response will be investigated, in order to identify signatures of Rashba spin-orbit interaction. To this end, dual-gate devices will be fabricated and their operation studied down to temperatures as low as 15 mK. Finally, the spin blockade regime will be exploited in order to explore the dynamics of single hole spins in SiGe islands. In particular, we aim to obtain important information on the characteristic time scales for spin relaxation and to perform coherent spin rotations by means of ac electric fields (via Rashba spin-orbit coupling). The proposed research project is also expected to create interesting opportunities for fundamental studies of exotic spin-related effects, resulting from the competition of ferromagnetic correlations, superconductivity, and Kondo effect.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of a consistent methodology to derive land cover information on a European scale from remote sensing for environmental modelling' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

TECHNICAL SUMMARY Work is described towards partial fulfilment of the objectives for the Environment and Climate Workprogramme, under Theme 3, Area 3.1 'Methodological research and pilot projects'. The primary research objective is that described for Section 3.1.1 'Methodological research', namely to develop a generally applicable methodology to compose a consistent land cover database for continental Europe. This project will also partly fulfil the re4uirements of Section 3.1.2. 'Pilot projects'. By performing case studies the applicability of satellite derived land cover information will be illustrated. The specific aims of research activities are: - to develop a general]y applicable methodology to map land cover at the scaleof Europe; - to establish a land cover database for continental Europe with a resolutionof 1-km for environmental monitoring, climate research and agriculturalapplications; - to apply models to estimate probable impacts of land cover / land use relatedto different kinds of pollution, e.g. nitrate and phosphate threat,emissivity of volatile organic components; - to develop a method for monitoring land cover change at European scale; - to improve the support towards decision-makers concerning environmentalissues. The proposal is divided into three main phases over a period of 3 years. Phase 1: development of methods for small scale land cover mapping and monitoring Phase 2: regional classifiation experiments Phase 3: environmental, climatic and agricultural applications
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Harnessing mechanisms for plant carbon delivery to symbiotic soil fungi for sustainable food production' (2021-2027) under Horizon Europe.

assistant: **Objectives**

The arbuscular mycorrhizal (AM) symbiosis between plants and symbiotic soil fungi confers key nutritional benefits to plants: AM fungi increase plant productivity by up to 30% by improving mineral nutrient uptake from the soil. In exchange for these nutrients, plants transfer more than one gigaton of photosynthetically fixed carbon each year to the AM fungal network in the soil. This carbon transfer has a major impact not just on plant and fungal physiology, but also on the global carbon cycle. My previous work identified a molecular pathway in plant roots that is activated during fungal colonization of root cells and transfers fixed carbon to AM fungi in the form of lipids. This finding represents a breakthrough in the field of AM symbiosis as we were able to describe, for the first time, how and in which form carbon is delivered to AM fungi. My discovery unlocks an opportunity: I propose to engineer the model crop rice to maximise carbon delivery to the fungal mycelium by exploiting the mechanisms underpinning carbon allocation to AM fungi. This approach could lead to enhanced nutrient uptake by promoting the symbiotic association, thereby reducing the need for synthetic fertilizer. Moreover, it also has the potential to increase carbon sequestration and soil fertility. However, it is currently unknown how plant carbon metabolism is altered at a whole plant level to increase carbon flux to the fungal mycelium, and how plants control the amount of carbon allocated to AM fungi. To achieve this ambitious aim, I will exploit the recent technological advances in genetics, carbon tracing, and single cell transcriptomics to map the carbon allocation pathway from leaves to roots and to AM fungi at single cell resolution (aim 1) and identify the genetic and transcriptional reg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'An exploration into the role of microRNAs in innate immune signaling' in the context of a Seventh Framework call.

assistant: **Objectives**

MicroRNAs (miRNAs) are important regulators of both innate and adaptive immunity. This is very much a frontier area since little is known about miRNA function in vivo, and there is still much discovery to be done. Their emerging functions indicate that they are as potent as cytokines in immunoregulation.We have found that Toll-like receptor (TLR) signaling is potently modulated by 2 particular miRNAs, miR-21 and miR-107. The programme will have 4 aspects which will build on this initial observation.1.Extension of our observations on miR-21 and TLR signaling. We found that the translational repressor PDCD4 is a key target.  We will study miR-21-deficient mice, construct a mouse model where the miR-21 seed sequence in the 3'UTR of PDCD4 is altered, and target miR-21 in vivo using antagomirs. We will also determine the mRNAs regulated by PDCD4 and examine the role of mTOR in PDCD4 control since PDCD4 is a possible substrate.2.Examination of the role of miR-107 in TLR signaling. TLRs dramatically decrease it¿s expression. We have found that miR-107 has an inhibitory role in TNF secretion via the targeting of CDK6. Activation of PPAR-alpha increases expression of miR107, which could be part of the anti-inflammatory effect of PPAR-alpha ligands.  We will explore miR-107-deficient mice and in vitro models of miR-107 function.3.Exploring the targeting of miR-155 by IL10, which we have recently found. The miR-155 target SHIP1 may be important in this system.  We will analyze this process in detail and determine other targets for miR-155 in IL10 action.4.Perform a screen for novel regulators of the aforementioned miRNAs and screen for miRNAs as regulators of other innate immune pathways, including Nalp3 and RIG-I, about which little is known. These experiments will yield new insi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Evolution of flower morphology: the selfing syndrome in Capsella'.

assistant: **Objectives**

The change from reproduction by outbreeding to selfing is one of the most frequent evolutionary transitions in plants. This transition is generally accompanied by changes in flower morphology and function, termed the selfing syndrome, including a reduction in flower size and a more closed flower structure. While the loss of self-incompatibility is relatively well understood, little is known about the molecular basis of the associated morphological changes and their evolutionary history. We will address these problems using the species pair Capsella grandiflora (the ancestral outbreeder) and C. rubella (the derived selfing species) as a genetically tractable model. We have established recombinant inbred lines from a cross of C. grandiflora x C. rubella and mapped quantitative trait loci affecting flower size and flower opening. Using this resource, the proposal will address four objectives. (1) We will isolate causal genes underlying the variation in flower size and opening, by combining genetic mapping with next-generation sequencing. (2) We will characterize the developmental and molecular functions of the isolated genes in Capsella and Arabidopsis. (3) We will dissect the molecular basis of the different allelic effects of the causal genes to determine which kinds of mutations have led to the morphological changes. (4) Based on population-genetic analyses of the isolated genes, the evolutionary history of the morphological changes will be retraced. Together, these strands of investigation will provide a detailed understanding of general processes underlying morphological evolution in plants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Industrial dynamics and employment in Europe'.

assistant: **Innovation**

The research project aims at explaining the relationship between the restructuring of the European economies and the employment issue, by considering its variable forms, its timing and evolution. The disequilibria affecting European countries in the decades starting with the seventies have been interpreted as the result of the inability of markets to cope with and to adapt to major changes in the general, economic environment (changes in technology as well as in the conditions and forms of industrial competition) that themselves were correlated with information imperfections and with the absence of appropriate counter-balancing institutions and incentive rules. In particular, the occurrence of mass unemployment in Europe has been imputed to structural maladjustments associated with an over-regulation of labour markets. By contrast, the perspective pursued in this research relies upon an altogether different line of interpretation of past economic histories and events as well as of the current dynamic paths of the crucial monitoring variables. In a nutshell, the explanation of the diverging performances of the Western countries (notably, in terms of the dynamic behaviours of unemployment) will not be sought uniquely in differences in the mechanisms controlling their labour market. It will also be located in their different investment behaviours. The disequilibria observed and their persistence, in fact, appear to be the shortcoming of inherited distortions in the structure of the countries' productive capacity, which itself descend from the conditions under which the process of capital accumulation has taken place. The distortions to be taken into due consideration and to form the focus of our analysis are not those affecting the relations between production sectors, as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'anti-Bacterial Innovative Vaccine Training Network.'.

assistant: **Objectives**

BactiVax (anti-Bacterial Innovative Vaccine Training Network) is a European training network (ETN) that will provide high-level training in vaccinology to a new generation of 15 high-achieving, early-stage researchers (ESRs). This innovative ETN uniquely blends cutting-edge research training, non-academic placements and transferable skills. It will develop strong entrepreneurial and creative mindsets. BactiVax will train ESRs in a broad range of transferable skills enabling them to thrive in careers in vaccine research within academia and/or industry through discovery, development, and delivery of innovative therapeutic and prophylactic vaccines. The World Health Organisation has identified antimicrobial resistance (AMR) as one of the three greatest threats to mankind. There is a urgent need to train innovative ESRs in the development of new vaccines against AMR infections. BactiVax will tackle the societal challenge caused by the emergence of AMR pathogens and have significant impact on pathogens causing chronic, life-threatening respiratory and/or systemic infections. BactiVax training will cover critical areas of vaccinology from early antigen discovery to optimisation of host response and delivery of vaccine antigens. It will also encompass the increasing problem of vaccine hesitancy in its public engagement. The specific research objectives are to: 1) Identify novel, protective vaccine antigens against target pathogens; 2) Optimise the host response to vaccines; 3) Optimise vaccine delivery; 4) Lead on vaccine advocacy. BactiVax includes 2 SME beneficiaries, a multinational vaccine company and 4 SMEs as partners all of whom are involved in training, entrepreneurship, commercial vaccine development and vaccine antigen processing. All ESRs will have secondments in no