RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Atypical Liquid Crystal Elastomers: from Materials Innovation to Scalable processing and Transformative applications' (ALCEMIST) targeting Horizon Europe.

assistant: **Abstract**

ALCEMIST challenges the conventional engineering mindset where passive static components (beams, wires, joints) are driven by active dynamic ones (motors, dampers, sensors); our innovative materials enable the combined functionality in a single component. This bold ambition is feasible because our research will unlock the full potential of liquid crystal elastomers (LCEs), unique responsive materials that reversibly change shape, colour, adhesive or damping properties, triggered by stimuli like heat, light, humidity or strain. We propose a radically new sustainable materials platform based on polysaccharides, functionalising precursors such that anyone-using click chemistry-can make LCEs that are powerful yet biocompatible and biodegradable, at one tenth of the cost of state-of-the-art LCEs. Further, using bond-exchange chemistry, ALCEMIST LCEs will be re-processable and re-usable. We also present a ground-breaking processing approach based on flow patterning to make large-scale LCEs of complex shapes and actuation modes. The synergy of three perfectly complementary and highly productive scientists, each a recognised leader in their field, enables this transformative approach to making atypical LCEs.As all our methods are ideal for industrial upscaling, we will also demonstrate the yet untapped potential of LCEs when they are applied in atypical contexts, totally different from the current mainstream academic focus. These range from adhesives that can be reversibly debonded on demand or sun-powered adaptive building elements which save energy and improve indoor atmosphere, to microhearts and peristaltic vasculature that can remove the growth limits of lab-grown organs, or smart threads that give doctors critical feedback on suture tension when conducting robotic surgery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'The Baltic BIT-House Network for promotion and dissemination of Information Society Research'.

assistant: **Innovation**

The basis for this project is a feasibility study carried out by 12 regions in 8 countries around the Baltic Sea to establish a network for launching ICT-based applications to promote the development of SMEs. Work is based on research on best practise in operating knowledge resource networks and from research on regional innovation systems and technology transfer. The BIT-House Net enables assessment, evaluation and testing of existing ICT-applications in different contexts. Understanding context specificity is critical as a means of learning and capability building in order to provide relevant services.The objectives of the BIT-House Net are to use the BIT-House Network as a platform for the dissemination of ICT-research results to promote the development of SMEs and to increase the degree of connectivity between and within the participating regions. The guiding principle is to establish a platform that might be used for various sorts of applications. The most tangible results of the project will be linked to that objective.The project will establish core-operating procedures and work methods for managing the network effectively and will develop models, practices and competencies making it an efficient platform for the deployment of ICT-based diagnostic and problem-solving business development tools, enabling human resource development through distance education, facilitating local content production, allowing the network to be a spearhead for the introduction and adoption of emerging business models.Objectives:The objectives of the BIT-House Net are to use the BIT-House Network as a platform for the dissemination of ICT-research results to promote the development of SMEs and to increase the degree of connected ness between and within the participating regions. The gui
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mitochondrial Precursor Proteins in the Cytosol as Major Determinants of Cellular Health' under Horizon Europe.

assistant: **Concept**

Mitochondria are made of 800 to 1500 proteins which represent up to 30% of the cellular mass. Owing to their post-translational mode of import, mitochondrial precursor proteins explore the cytosol before they are imported into mitochondria. These reactions are of utmost importance for cellular functionality since cytosolic precursors pose a major threat of cellular proteostasis and are major drivers in aging and for the pathogenesis of neurodegenerative diseases. Still, the biology of cytosolic precursors is largely elusive.In vitro import assays governed the experimentation platform of the mitochondrial community which enabled exquisite breakthroughs in understanding translocation, but are unsuited to elucidate cytosolic reactions. MitoCyto aims to break out of these experimental walls to elucidate the biology of cytosolic precursors with an interdisciplinary research team that leaves the comfort zone of biochemistry to utilize genetic and cell biology approaches but also develops novel cutting-edge techniques from high throughput approaches, through microfluidics-assisted microscopy to synthetic biology. From this innovative combination, detailed mechanistic insights into three so far largely elusive aspects of cell biology will be possible for the first time: (1) What are the cytosolic interactors of mitochondrial precursor proteins? (2) What are the direct and indirect physiological consequences of cytosolic precursor accumulation? (3) How does the re-routing of mitochondrial proteins to the nucleus control growth and fitness of eukaryotic cells?We are convinced that MitoCyto will break grounds to a comprehensive understanding of how eukaryotic cells maintain a healthy proteome over a lifetime despite fluctuating metabolic conditions. While these goals are conceptua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The port as a hub in the intermodal chain' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

EUROBORDER sets out to analyse the processes connected to the vehicles, load units and the related information, within the ports as well as between ports and their different customers (e.g. forwarders and shippers). EUROBORDER intends to meet the objectives listed in the Work Programme by :* focusing on the procedures (information flow, organisation, administration) in the port,* relating these procedures to the interaction with participants of the intermodal transport chainAnalysing the procedures in the ports also means analysing the interacting transport services ; road, rail and sea as well as the funtions of the supporting forwarders and agents. However, the level of detail changes with the distance" from the port and the sea transport leg.The main objective of EUROBORDER is :To estimate how changes and development related to the port will impact on the port's attraction as a node in the intermodal transport chain. Such measures could be changes and improvements of old procedures, but could also incorporate development of new services.The task of EUROBORDER is :* to map and model the procedures,* to define and describe the system (time/costs) to be studied and its boundaries,* to identify problems and bottlenecks of the system in relation to the user requirements* to propose a tentative list of measures for improvement (as scenarios if meaningful)* to assess the potential impact of improvements in the port and the importance of such changes in relation to the whole transport chain* to propose measures for implementation and/or testing %"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of immunogenic and safe vaccinia virus vaccines' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Vaccinia virus recombinants engineered to express foreign genes have great potential as new live vaccines against infectious diseases. Modified vaccinia virus Ankara (MVA) is a promising human vaccine candidate due to its restricted host range, avirulence in animal models, excellent safety record as a smallpox vaccine and potent immunogenicity. This proposal intends to investigate various aspects of vaccinia virus in order to improve and develop MVA as a recombinant human vaccine.  Safety of recombinant vaccines. The molecular cell biology of MVA will be investigated and vaccinia virus proteins required for virus assembly and entry into cells will be characterised. This will lead to the identification of proteins that can be deleted from the viral genome and restrict even further the replication and dissemination of MVA in vivo. The role of vaccinia proteins that modulate the host immune response, such as soluble cytokine receptors or proteins that protect infected cells from interferon effects, will be investigated in the infected host. Deletion of these vaccinia genes may increase the susceptibility of vaccinia recomhinant to the attack of the immune system and also restlict virus spread.  Immunogenicity of recombinant vaccines. Vaccinia recombinants that may be used in human medicine will probably have deficient replication, thus the immunogenicity of the expressed foreign antigens will need to be enhanced. The research project will use different approaches: i) to display foreign antigens at the surface of virions; ii) to determine the inlluence of vaccinia immunomodulatory proteins; and iii) to express host cytokines that can promote immune responses.  These studies will lead to the development of safer and more immunogenic MVA recombinants, which will be tested as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Living Rivers and the New Water Justice Movements: From Dominating Waterscapes to the Rights of Nature', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

RIVERHOOD will study, conceptualize and support evolving water justice movements that struggle for enlivening rivers. Notwithstanding rivers’ fundamental importance for social and natural well-being, around the world, mega-damming, pollution, and multiple forms of domesticating are putting riverine systems under great stress. Expert ontologies and epistemologies have become cornerstones of powerful hydraulic-bureaucratic administrations (‘hydrocracies’). Recently, worldwide, a large variety of ‘new water justice movements’ (NWJMs) have proliferated. These are rooted, transdisciplinary, multi-actor and multi-scalar coalitions. They deploy alternative river-society ontologies and practices, challenging hydrocracies’ paradigms to foster environmental justice. They translate global notions into local ones and vice versa. New, exciting strategies range from organizing river-health clinics, dam removal, socio-ecological flow projects, to mobilizing New Water Culture and Rights of Nature notions. European NWJMs co-learn with peers in Ecuador and Colombia were rivers are legal and political subjects. NWJMs hold immense potential for contributing to a radically new, equitable and nature-rooted water governance, but are undertheorized, largely unnoticed by natural and social sciences, and excluded from policy-making. Science and policies lack approaches to engage with rivers as arenas of co-production among humans and nature. RIVERHOOD will develop a new analytical framework to study NWJMs and ‘riverhoods’. Socio-natural river complexes will be approached from 3 interrelated ontologies: ‘river-as-territory’; ‘river-as-subject’; and ‘river-as-movement’. Through 4 cross-cultural PhD studies, 8 cases in Ecuador, Colombia, Spain and the Netherlands are investigated. At each site ‘Env
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Implementation of concepts and methods from non-commutative geometr y to operator algebra and its applications in mathematical analysis and quantum physics' (1994-1998).

assistant: **Concept**

Most of the proposed funding will be used to support young researchers at mathematics, interacting not only with neighbouring fields (foliations, post-doctoral level through a programmeof exchanges between the various index theory, K-theory, cyclic cohomology, affine Kac-Moody algebras, teams in the network. quantum groups and manifold in variants) but also having applications in theoretical physics (integrable theories, statistical mechanics, conformal field theory and the string theory of elementary particles). The realisation underlying this success is that a non-commutative concept of geometry and topology can be imposed on most classical spaces. The implementation of this program, which has found its most exhaustive form in A.Connes' recent monograph, will be the ultimate goal. A well-established network, comprising the leading European researchers in the field, will work on various aspects of this program, with particular emphasis on guidance and training of the next generation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Canadian European research initiative on nanostructures' in the context of a Fourth Framework call.

assistant: **Objectives**

The CERION Working Group will co-ordinate the research of 17 European and 8 Canadian nodes, actively participating in research on nano-electronics, nano-optics and the technology of advanced nano-structures.The research activities will be oriented towards the following results:- development of nano-optic and micro-structured photonic devices, e.g. quantum dot lasers, modulators, amplifiers, non-linear semiconductor waveguides for wavelength shifting;- development of nano-electronic transport devices, e.g. quantum dot resonant tunnelling diodes and metrological applications based on single electron effects;- general theoretical and experimental characterisation of electrical and optical transport properties of nano-structures and mesoscopic systems and the identification of their operational limits;- investigations of novel systems, e.g. hybrid semiconductor and magnetic systems.Results will be published in recognised scientific journals on a regular basis and the scientific parts of the annual progress report will be directly communicated to the European and Canadian microelectronics industry.CERION will provide financial support for the following activities:- scientific visits made by European researchers to their Canadian colleagues- attendance at the CERION workshops by the European partners - organisation of the CERION workshops:- local organisation (only if performed by a European partner)- coverage of travel and living expenses incurred by invited speakers attending a CERION workshopA wider target group consists of European and Canadian universities, research institutes, microelectronics companies and European programmes related to nano-technology (incl. The Phantoms Network of Excellence, MEL-ARI consortia etc.)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Cluster decorated recognition elements on DNA origami for enhanced raman spectroscopic detection methods'.

assistant: **Innovation**

The project ""DeDNAed"" is intended to develop a novel, innovative biosensing platform whose advantages and benefits are in terms of sensitivity, versatility and being ultrafast by an optical approach. Our platform will be based on the assembly and integration of sensing elements (transducer and bioreceptor) by DNA origami. The DNA origami will serve as a “nano bread board” in order to precisely control the position of these elements and thus the sensor architecture at the nanometer scale. Metallic atomic clusters (ACs) are integrated into a biological marker molecule (DNA or antibody) and thus represent the biological sensor element. This is specifically integrated into a nanoarray made of additional metallic nanoparticles precisely controlled by a DNA origami template and will lead to a significant increase in signal. DNA origami serves as an individually inter- and intramolecularly programmable nano bread board. A DNA origami consists of a single strand of DNA, folded by a thermal treatment and certain staple strands into any shapes (2D as well as 3D, dimensions between 10 and several 100 nanometers). So-called ""sticky ends"" on the surface of the DNA origami offer the possibility of an individual implementation of the sensing elements and NPs, by means of correspondingly complementary oligonucleotides with a resolutions of 2 nm. When the analyte is connected to the sensor element, a change in the Raman signal can thus be detected without major delay using surface-enhanced Raman spectroscopy (SERS). This sensor method is not bound to a specific biomarker molecule for the sensor element, but can be transferred to different marker molecules. This means a high degree of flexibility in the area of application, from medical technology to food monitoring. In addition, a t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Neuromuscular-Junction-on-a-Chip to study medication for Parkinson' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

While Europe is still missing publishing researchers working on brain-a-chip devices, scientists and pharmaceutical companies growing interests in investing in organ-on-a-chip devices urges because these lab-on-a-chip devices offer highly accessible systems for proof-reading and testing hypothesis-driven research. Chips allow ultra low-cost test benches for medication and offer flexibility to healthcare. This biotechnology set the first milestone for bio-prosthesis and in situ implants.In the scope of this H2020 MSCA Fellowship, I propose to elaborate a neuromuscular-junction-on-a-chip, induce Parkinson with the well known α-synuclein and proactively test medication proposed by Novartis and Glaxosmithkline on the chip. The proposed schematic is designed to bring closer academia and industry, research and innovation, from design to market. Elvesys, microfluidic center innovation in Paris is the beneficiary of this H2020 MSCA Fellowship. Elvesys team is creating a microfluidic valley in France, with the vision focus on Regenerative Medicine. During this project, I am aiming at improving Europe's stance as a leading organisation in bioengineering and an attractive destination for research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integrated Precision Medicine Technologies Research Centre of Excellence' (IPMT) under Horizon 2020.

assistant: **Objectives**

Most medical interventions are effective in only a small percentage of the patients. The multifactorial nature of disease and patient differences in presentation, genetics and exposures have been implicated as the causes. Precision medicine aims to maximize the effectiveness of medicine by tailoring the diagnosis and treatment to match individual patients. This proposal will establish an Integrated Precision Medicine Technologies Research Centre of Excellence, a multidisciplinary centre which will be a leader in the development of new technologies to further enable and accelerate the progress and application of precision medicine. The Centre will include all the essential fields: (i) modelling & simulations, (ii) intelligent systems & bioinformatics, (iii) imaging & biosignal analysis, (iv) digital & eHealth, (v) embedded systems & electronics, and (vi) sensing technologies (including nano), with support from (vii) biosciences and (viii) clinical validation. Initially, the clinical emphasis will be on tools and methods for relevant multifactorial diseases: cancer, neurodegenerative disorders and traumatic brain injury. The proposal is a collaboration between leading Cypriot and European institutions. The host, the University of Cyprus, is the country’s leading academic institution, with local partners including major medical centres as well as support from the Ministry of Health and other private organizations. The advanced partners are the Fraunhofer Institute for Biomedical Technology (BMT), Germany, and the Centre for Biomedical Research - Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN), Spain. The experience of the partners, combined with the synergies created by this project, provide a great opportunity to establish a sustainable Centre which will (i) condu