RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of recombinant LAB for the treatment of Food Allergy Disease by targetting intestinal Dendritic Cells' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

This proposal will allow me to advance my career as an independent researcher, to take on the leadership of a research project and to gain additional knowledge and experience of project management, identifying opportunities to innovate and engaging in trans-disciplinary research. The prevalence of allergic disease has trebled in the last 20 years and it is estimated that 1-2% of European adults [5-7% of children] suffer from food allergies. Therefore, the project is consistent with FP6 Priority Thematic Area 5-Food Quality and Safety.   The gastrointestinal tract is constantly bombarded by dietary proteins, all potential antigens. Two differing therapies against allergies have been used, a Th1 cytokine (IL-12), and a commensal bacteria inducing IL-12 at intestinal DCs level to regulate Th1-Th2 response in favour of Th1.   This innovative project will examine an additive/synergistic effect by using recombinant lactic acid bacteria (LAB) strains producing IL-12. Briefly, LAB strains will be engineered to produce IL-12. In order to check a possible regulation of Th1 response at gastrointestinal DCs level, a unique peanut allergy mouse model developed at the Institute of Food Research (IFR) will be challenged with LAB strains producing IL-12. My existing skills will be extended in molecular biology and initiated in immunology areas, in which the host is globally-networked.   IFR is internationally recognized and can offer me other scientific and complementary training courses [ISO-9001 quality regulated] including presentation and communication skills, ethics, innovation, FP7 opportunities, networking, resource, project management and hosts contacts. Which research pathway I will choose will depend, in part, on the outcome of my stay at IFR. The added knowledge gained will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Computational multiplexing to optimise next-generation sequencing' (MultiSeq), addressing dissemination and exploitation.

assistant: **Impact**

Recent advances in Next-Generation Sequencing (NGS) of nucleic acids (i.e. DNA or RNA) have transformed biology and medicine. Today NGS is one of the main pillars of research in various biological disciplines, and it has already pervaded numerous fields of applications ranging from clinics to the biotechnological industry. Given its versatility and high demand, the global market for NGS is rapidly expanding, with the number of sequenced samples doubling every two years. However, while major advances in NGS were mainly related to a rapid increase in sequencing throughput per machine, the preparation of sequencing libraries - the otherintegral step of NGS, has largely remained unchanged. Currently, this step is the major financial and operational bottleneck for sequencing projects, limiting the widespread adoption and utility of NGS. Current state-of-the-art solutions for overcoming these problems either require high upfront costs and/or are laborious. We are developing a bioinformatics solution to these problems, which minimizes the cost and time of library preparation. Our approach, called MultiSeq, allows designing a multiplexing strategy to reduce the number of libraries followed by computational demultiplexing. We plan to extend the experimental proof of concept of our method by applying it to broadly sequenced species. In addition, we will integrate our algorithms into a versatile computing framework and develop a pilot project in an industrially relevant context. In parallel, we will perform market analysis and evaluate the most suitable IP protection and commercialization strategies of our technology. If successful, MultiSeq will be a game-changing approach that will impact sequencing technology and related industries by further democratizing the field of NGS and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A Biophysical Investigation of the Duality in Fas Receptor' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Membrane receptors control fundamental physiological processes in cells, and are major targets of medical drugs. The goal of this project is to investigate the nanoscale motion of the membrane receptor Fas and its functional role in maintaining immune surveillance. Fas is ubiquitously expressed in human body and has significant roles in disease progressions. A type I single pass transmembrane protein, Fas is known for its ‘dual character’ in triggering signaling pathways leading to both cell survival and cell death. In the presence of its ligand, the receptor undergoes higher-order clustering to form a death-inducing signaling complex (DISC) in the intracellular region. Immune cells use Fas-mediated DISC formation as a mechanism to ‘kill’ virus infected or malignant cells. The Fas ligand, which is a type II transmembrane protein, can be cleaved which results in its soluble variant. Unlike the membrane anchored Fas ligand, the cleaved variant is known to induce an alternative motility inducing signaling complex (MISC) in Fas receptor that results in cell migration. Although the functions of the Fas receptor (and the notion of duality) are well established, how it selects for non-apoptotic or apoptotic pathways is an open question. It has been postulated that the membrane bound and cleaved variants of the Fas ligand induce different structural orientation and conformations in the intracellular domains of the receptors to control DISC/MISC formation. However, due to the immediate higher order aggregations upon ligand-binding and the presence of other modulating proteins during in-vivo experiments, it has been a great challenge to test this hypothesis. This project will investigate the biophysical mechanism behind the duality in full-length Fas receptors by exploiting singl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sexual Citizenship and Disability - Implications for Theory, Practice and Policy', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The sexuality of disabled people is a taboo subject in disability services, health care and in society as a whole. Additionally, physical inaccessibility, lack of social policy and failure by professionals to recognise the needs of disabled people to be supported in their sexual expression can lead to unmet needs, misconduct and reproduction of stereotypes of disabled people as asexual. In the findings from a participatory action research project that sought to identify future priorities for disability research, the issue of sexual support was suggested as such a priority by disability rights organisations. In many countries a new generation of service users are growing up with recognised human rights through strengthened disability policies and discrimination laws, as well as being backed up by European and global conventions – notwithstanding often only briefly mentioning sexual rights on an abstract level. The aim of this study is to analyse the conditions, implications and consequences of claims for sexual facilitation on a policy level in three countries: The UK, The Netherlands and the state of New South Wales in Australia. Disabled people have vastly different possibilities for sexual recognition and expression in different policy contexts. Adopting a mixed-method design, including critical policy analysis, interviews, and workshops, with a comparative case study approach allows for a qualitative insight into the policy processes as well as their consequences in practice. A central aim of the study is to develop good practices together with local disability rights organisations in order for research results to not only contribute to theoretical understandings of sexuality and disability, but also to developments in policy and practice, based on expert knowledge a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Entanglement creation and detection in quantum optical systems' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

We propose to study many-body entanglement quantification, detection and the creation of large-scale entanglement in connection with the recent experiments on cold gases, atoms in optical lattices, etc. This research would bridge the gap between quantum in formation and the physics of cold gases, would help interpreting experimental results from point of view of quantum information, and would also help designing new experiments.Ways of entanglement quantification in many-body systems will be studied in the above-mentioned physical systems. It will be determined, what degrees of freedom are relevant in a certain scenario from the point of view of entanglement. I will identify necessary conditions for separability in these relevant degrees of freedom. Based on these conditions many-body entanglement quantification is possible.The measures constructed should reflect how the many-body quantum state can be used as a resource in several tasks in quantum information or should correspond to the effect of some fundamental physical process in the system. Using the measures found, methods for the experimental detection of many-body entanglement will be developed. These must be based on quantities easily accessible in experiments. Based on the measures constructed, entanglement creation properties of physical processes will be studied.The main questions are- how much entanglement can be created with a particular physical process starting out from a non-entangled state?- How can one optimize the process for maximum entanglement creation?- How decoherence affects the dynamics?- How can the dynamics protected against decoherence, i.e., how can the dynamics be purified?The physical processes ('general physical actions') will be studied using completely positive maps exploiting the esta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tephra constraints on rapid climatic events' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Little has challenged our understanding of climate change more so than the abruptness with which large-scale shifts intemperatureoccurred during the last glacial period. Atmospheric temperature jumps of 8-16°C, occurring within decades over Greenland,were closelymatched by rapid changes in North Atlantic sea surface temperatures. Though these climatic instabilities arewell-documented in variousproxy records, the causal mechanisms of such short-lived oscillations remain poorly understood. Two hypotheses have beenproposed:one relating to the behaviour of the ocean circulation and the other to the dynamics of the atmosphere. Testing thesehypotheses,however, is severely hampered by dating uncertainties that prevent the integration of proxy records on common timescales.As a resultunravelling the lead/lag responses (hence cause and effect) between the Earth’s climate components is currently beyond ourreach.TRACE will exploit a powerful new approach whereby microscopic traces of volcanic events are employed to preciselycorrelate proxyrecords from the North Atlantic region to assess the phasing relationships between the atmosphere and the ocean duringthese rapidclimatic events. Volcanic layers have the unique advantage of representing fixed time-lines between different proxy records.Thiscorrelation tool has experienced a considerable step-change in recent years, with invisible layers of volcanic ash traced overmuch widergeographical regions than previously thought. What is more, recent work has identified new, previously unknown eruptions -several ofwhich coincide with the rapid climatic jumps imprinted in the proxy records. Thus tephra isochrones represent (perhaps theonly)independent constraints for resolving past events on decadal timescales.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Novel structural monitoring solution for safe and sustainable post-tensioned infrastructure'.

assistant: **Objectives**

Collapsing buildings, bridges and other infrastructure are unfortunately still a common occurrence. Since 2000 more than 100 bridges have collapsed killing over 700 people and costing billions of euros in lawsuits, repairs and replacements. The recent Genoa bridge collapse is a tragic example. Many of the concrete infrastructure in Europe does not have structural health monitoring solutions (SHM) in place as a result of the high complexity and costs of available solutions. PT-SMS innovation project aims to commercialize a novel Structural Health Monitoring (SHM) solution for post-tensioned concrete. Post-tensioning is a popular method to strengthen concrete buildings, bridges, dams and other infrastructure. 3S'TECH has developed a unique strain-gauge based sensor system optimized for post-tensioned (PT) monostrand monitoring that is easy-to-install, low-cost, 95% accurate and durable (20+ years), thereby providing superior performance over current market solutions. Backed by a Big Data Platform and Artificial Intelligence, PT-SMS will allow infrastructure owners to ensure the safety of their structures while reducing OPEX by 25% through predictive maintenance. Construction companies on the other hand benefit from much higher control over the tensioning process drastically reducing delays and delivering high quality work. Its design simplicity allowing self-nstallation by PT construction workers will provide a fast path to market entry through partnerships with leading European PT companies such as VSL and Freyssinet. The SHM market for concrete is growing fast with bridges alone reaching 464 M€ and CAGR of 15.6%. Ptototype tests have already been successfully carried out at a VSL construction site. Upon full commercialization of our technology in 2021, 3S'TECH will esta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Dissecting transcription termination and RNA sorting in MYCN-driven tumors'.

assistant: **Objectives**

The inherent stresses arising from oncogenic transcription can be counteracted by premature termination which removes RNA polymerase II (RNAPII) from DNA and enables the degradation of aberrant nascent RNA by the nuclear exosome. When overexpressed, the MYCN oncoprotein fuels the growth of aggressive tumors by globally binding active promoters and invariably enhancing RNAPII transcription. However, I have made two key discoveries showing that the function of MYCN is not restricted to gene activation: Firstly, MYCN interacts with the exosome and prevents conflicts of RNAPII with replication forks to avert lethal DNA damage. Secondly, MYCN globally leaves promoters and directly binds nascent RNAs which are then steered to the exosome for decay. RNA bound MYCN also forms large protein complexes comprising the ARS2 transcript sorting protein, RNAPII and termination factors. These findings fundamentally expand MYCN function as they reveal that the oncoprotein exists in competing DNA- and RNA-bound states with the latter fulfilling a heretofore unknown RNA degrading role.In TerSor, we will investigate whether RNA-bound MYCN controls termination and RNA sorting processes to counteract aberrant transcription and thereby suppress DNA damage and immune recognition in neuroblastoma cells. Firstly, we will map MYCN RNA-binding domains and test the effects of RNA-binding loss in cells and neuroblastoma mouse models. Secondly, we will explore MYCN-driven regulation of termination and RNA sorting machineries. Thirdly, we will investigate how the exosome and MYCN mitigate DNA damage and the accumulation of immunogenic transcripts. Finally, we will study the structure of MYCNs interface with exosome targeting complexes.Collectively, we will use cutting-edge approaches to profoundly furt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Arabic Poetry in the Cairo Genizah' (APCG), addressing dissemination and exploitation.

assistant: **Impact**

Poetry enjoys a special place in Arabic culture and literature. For centuries, Arabs of all faiths have considered poetry a key source for knowledge, intellectuality and wisdom. In the pre-Islamic era, poetry was considered as ‘the Arab knowledge’ and ‘the Arab cultural archive’, in which the social and cultural history, language, arts, music, religious and Arab’s human experience were stored and preserved. Being a part of Arabic culture, Jews of Arab lands equally enjoyed writing and reading poetry. APCG will investigate for the first time a hitherto neglected collection of Arabic poetry fragments written in Hebrew script (in Judaeo-Arabic), which has been preserved in arguably the most important Jewish treasure trove: the Cairo Genizah. The fragments, numbered in the hundreds, constitute a unique source for understanding medieval and Early Modern Egypt from three main perspectives: Arabic studies, Jewish social and cultural studies, and anthropological studies.      The core aims of the project are:    • to make the entirety of Arabic and Judaeo-Arabic poetry in the Cairo Genizah accessible to both academic scholars and to the public in a comprehensive database and in critical editions;    • to reveal, through the study of poetry, hitherto hidden aspects of social and cultural history of the Jews in the Middle East with regard to literacy, education and intercommunal relations;    • to explore hierarchies, interpersonal relationships and the social function of poetry in medieval and early modern Egypt through the study of Genizah poetry.      To achieve the planned main objectives, APCG carries out a thorough interdisciplinary study of Genizah’s Arabic poetry. This approach involves research from philological, linguistic, literary, historical and anthropological persp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'One Business Place' (OBP) targeting Horizon 2020.

assistant: **Abstract**

OBP (One Business Place) aims to provide a solution to the massive online visibility problem that millions of micro SMEs in Europe are facing. Despite they are regarded as the backbone of the European economy, important source for jobs, SMEs are losing online visibility with massive explosion of big data in the Internet era. This phenomenon is caused by two main factors:  1) more than 40% do not have a website yet and 2) they are not transparently shown in web searches, as the order of results is influenced by optimized, sponsored and paid business results. Therefore, small local businesses are suffering clear erosion in their individual sales, taxable sales for government revenue, which is based on local consumers (B2C) and services to other business (B2B). This problem is of vital relevance for the EU.OBP is a dedicated search ecosystem for European micro SMEs, will provide transparent, relevant and global online visibility, facilitating the matching of business to consumers (B2C) and business to businesses (B2B), eliminating any disintermediation’s. OBP is crowd sourcing, ads free search model coupled with semantic database technologies built on the combination of both open and our private data sources. This product also has potential to extract commercial value from open data and increase private data profitability.The goal of our project is to make OBP a global success, able to revolutionize the on-line visibility and search for SMEs, while allows us penetrate into the European on-line directories market, which is growing fast at 17,5% CAGR. OBP is for the people by the people and to the people to make European SME local knowledge globally available.We plan to undertake in this Phase 2 an ambitious innovation project deploying OBP as a pilot in Spain, Portugal and