RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Small ligands to interfere with Thymidylate synthase dimer formation as new tools for development of anticancer agents against ovarian carcinoma' to be submitted under Sixth Framework.

assistant: **Abstract**

Ovarian cancer is the fifth most common cause of death from cancer in women. The standard firstline treatment is a combination of paclitaxel and carboplatin (DDP) or carboplatin alone. Age, performance status and treatment preferences of the individual patient help in selecting single or combination therapy. In the case of progressive disease or drug resistance treatment with platinum, either alone or in combination, especially investigational compounds should be used. Themechanisms behind acquired resistance to cDDP and its derivatives are not clear yet, although it is evident that the process is multifactorial including, enhanced DNA repair. In the human ovarian carcinoma cell line A2780, a 3-fold-DDP-resistance was associated with cross-resistance to the thymidylate synthase (TS) inhibitor 5-fluorouracil and to methotrexate, a 2.5-fold increase in TS, and an increase in the intracellular pools of the TS cofactor 5, 10-methylentetrahydrofolate and of tetrahydrofolate. The ultimate goal of LIGHTS is to directly halt tumour progression and the development of drug resistance upon treatment with platinum derived drugs by inhibiting the protein regulatory function of monomeric TS through small molecule cellular perturbation. The scientific and technological objectives will be to design small-ligand libraries to bind to the TS monomer (dimer interface) and thereby disrupt TS.The strategy will include, protein system analysis, protein labelling to identify low-affinity ligands, peptide mimic design & synthesis, and filtering for ADME properties. The multidisciplinary approach will be carried out by a consortium integrating Molecular modelling, Chemistry, Chemoinformatics, Structural Biology and Pharmacology, and will apply the knowledge being created by genomics and other fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Coalonialism: Energy and Empire before the Age of Oil' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This is a multi-sited historical research into the geopolitical, social, and cultural implications of energy shifts during the long nineteenth century (1800-1911). Combining perspectives from archives in London, Istanbul, Cairo, and Jerusalem, I retrieve the so far ignored “age of coal” in the Middle East. Examining the mutually reinforcing role of British colonialism and fossil fuel extraction and proliferation, I aim to decenter Eurocentric understandings of industrialization by demonstrating the importance of colonial coal markets for financing Europe’s modernization and for providing overseas locations which prompted innovation in carbon-fueled technologies. Simultaneously, I concretize understandings of the power to colonize by following infrastructures like colonial coal-depots, steamer and rail lines.How is it possible, I ask, that English and Welsh coal facilitated the development of participatory forms of politics in England, while simultaneously solidifying authoritarian political structures when exported to a place like colonial Egypt? By following the different possibilities afforded by coal to English and Ottoman miners, coal-heavers in colonial ports, and to centralizing states reliant on newly-introduced transportation and communication technologies to control their populations, I will demonstrate how the different channels of coal propagation provided different kinds of leverage for historical actors. Finally, beyond coal’s significance in illuminating historical processes, it also reveals their ongoing implications in the present. In particular, it is impossible to understand the age of oil in the Middle East without attending to the colonial legacies of fossil fuels.As a historian specializing in the introduction of science and technology to non-Wester
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Research and development of a highly automated and safe streamlined process for increased Lithium-ion battery repurposing and recycling' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The increasing e-mobility will trigger a battery waste problem (9Mtons/year by 2040) despite that many of the used LIBs are suited for 2nd-life applications for an additional 10 years, representing an opportunity to diminish energy and raw materials dependencies in Europe.Technical hurdles are preventing the re-use and recycling of Li-ion batteries. Besides the heterogeneity of the battery stock, assessing their condition for further usage is a slow process performed with equipment not suited for industrial contexts while. Dismantling packs and modules is in addition a costly and slow manual process because its automation faces extremely complex, multi-scale, cluttered and densely packed environments. REBELION will validate two circular schemes (including Light e-vehicles) to maximise 2nd life utility and domestic applications, enabled by a disruptive fast battery testing based on Electronic Noise Analysis, and an autonomous pack and module disassembly system with re-configuring capabilities for the ongoing battery types and formats. Additionally, a novel labelling system supported with blockchain, digital battery passport and ecolabel technology will provide key information to dismantlers, recyclers, re-manufacturers and users.Processing large volumes of used batteries increases the risks of thermal runway incidents, requiring thus novel safety protocols and systems. REBELION will add thermal monitoring and the design of a smart container for storage and transportation with thermal and gas sensing layers to monitor the limiting oxygen index and lower explosive limits, and a cooling system that activates when thresholds are surpassed.REBELION consortium covers all the value chain, including advanced robotic line and car manufacturer, bringing key knowledge, proprietary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'HEPATITIS C VIRUS AND HOST LIPOPROTEIN METABOLISM' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Over 3% of the world population is chronically infected by the hepatitis C virus (HCV). Chronic infection is associated with liver disease that leads to fibrosis and cirrhosis and ultimately to hepatocellular carcinoma (HCC). There is no vaccine for HCV and the current treatment is only partially effective and toxic. Consequently, HCV infection is one of the leading causes of liver transplantation worldwide. HCV depends heavily on cellular lipid and lipoprotein metabolism to replicate and produce infectious particles. This dependence coincides with the fact that chronic HCV infection is associated with alterations of the liver lipid metabolism. These alterations are manifested by abnormal accumulation of lipids in hepatocytes (steatosis) in a significant proportion of the patients. In patients responding to interferon treatment, steatosis subsides as the viral titers decrease, suggesting that HCV replication and viral protein expression are a major determinant for these alterations. However, little is known about the molecular mechanisms underlying the interference of HCV infection with lipid metabolism. Understanding how HCV exploits the cellular lipid and lipoprotein biosynthetic machinery might contribute to understanding important aspects of the pathogenesis of chronic HCV infection. In this application, we propose to use a cell culture HCV infection model that we recently developed to study the intersection of cellular lipid and lipoprotein metabolism with basic aspects of HCV infection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'High-dimensional probability in ergodic theory and representation theory', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

This project begins with the interaction between (i) convergence and limits for labeled bounded-degree graphs and (ii) the This project begins with the interaction between (i) convergence and limits for labeled bounded-degree graphs and (ii) the ergodic theory of possible limit processes over infinite graphs, regarded as stationary processes for infinite groups of symmetries. It will deliberately focus on foundational issues that cannot be addressed using the most standard tools: models that are at ‘low temperature’, so mean-field and related methods do not provide good approximations; and limiting graphs that are not ‘amenable’, meaning that they do not allow approximations by decomposing into finite pieces with only ‘small’ interactions between them. The first goal of this project is to uncover new approaches that draw on notions of convergence for sparse graphs, conjectures about the behaviour of high-dimensional graphical models in statistical physics, and the ergodic theoretic study of limit processes via sofic entropy and related concepts.To shed new light beyond the reach of established techniques, the project will take inspiration from an analogous emerging theory where some of the same challenges can be addressed. This theory studies unitary matrices (rather than labeled graphs) and limiting unitary representations (rather than infinitary stochastic processes). The PI has recently been developing an analog of sofic entropy in this new setting. Several open problems about graph convergence admit analogs about tuples of unitary matrices, and the PI has already solvedsome of these using ideas from random matrix theory or operator algebras. The second goal of this proposal is to grow this new chapter in random matrix theory, where many further questions are now wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Exploiting the hypoxia response in T cells for Next-Generation Immuno-Oncology' to be submitted under Horizon 2020.

assistant: **Abstract**

NextGen_IO has a core focus on immuno-oncology, specifically on target discovery and drug development, to exploit several opportunities that the hypoxia pathway in T cells offers for the treatment of cancer. It is well recognised that the clinical response of immunotherapies depends on the ability of T-cells to mount an effective effector response, persist in treated patients and avoid exhaustion and toxicities. Several approaches to immunotherapy have shown promise in clinical trials, especially the use of immune checkpoint inhibitors and, more recently, autologous adoptive T-cell therapies. However, current state-of-the-art immunotherapies are only effective in a small fraction of patients, offering a medical need to be addressed in several cancer types. Importantly, the tumor microenvironment has specific features that impact the immune response, including decreased oxygenation, aberrant vascularization and altered nutrient availability; all these influence the success of immunotherapies.  During the last 10 years, my research has been focused on elucidating the role of the oxygen sensing machinery in T cell function, and the link of hypoxia-driven metabolism and epigenetic modifications with T cell differentiation into effector and memory T cells within the context of cancer immunotherapy. The current proposal aims to exploit these previous findings with a multi-disciplinary strategy, to deliver several early-stage drug discovery outputs.The main objectives are: 1. Development of a novel small molecule inhibitor to modulate the hypoxic response in T cells. 2. Therapeutic target discovery in T cells, focused on hypoxia-driven epigenetic modifications. 3. Development of hypoxia-inducible molecular switches for adoptive T cell therapy.Successful completion of the proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Beyond CULtural TOURism: human-centred innovations for sustainable and circular cultural tourism' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Cultural tourism entails opportunities but also risks. If not managed properly, cultural tourism can easily turn into a “value extractive” industry, generating negative environmental, social and cultural impacts on local communities and ecosystems. This project will develop specific strategies to promote an understanding of cultural tourism, which moves away from a “stop-and-go” consumer-oriented approach towards one that puts humans and circular economy models at its centre, paying attention to nature, communities and cultural diversity. “Place”, intended as the genius loci, the ancient spirit of the site and “people” as co-creators of its uniqueness, culture, art, tradition, folklore, productivity, spirituality, are the focus of Be.CULTOUR.Wide and diversified partnerships of stakeholders from 18 EU and non-EU regions of Northern-Central and Southern Europe, the Balkans, the Eastern neighbourhood and the Mediterranean, will be the driving force of the project. A community of 300 innovators (which includes regional authorities and municipalities, clusters and associations, museums and tourist boards, entrepreneurs, chambers of commerce, citizens, researchers, practitioners as well as project partners) in 6 pilot regions will co-create innovative place-based solutions for human-centred and circular cultural tourism.Collaborative “Heritage innovation networks” will be established in 6 European deprived remote, peripheral and deindustrialised areas and cultural landscapes identified as “pilot heritage sites”: committed to the project’s objectives, they have defined clear cultural tourism related challenges requiring innovation, which will serve as the basis for the collaboration with 12 additional “mirror ecosystems”.


**Keywords:** Cultural tourism, Europeanisation, Cul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ecofridge' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The ecofridge addresses a new concept in the movement of heat sensitive products -- a unique package unit that stores flat, is reusable, recyclable and offers superior thermal qualities than polystyrene boxes (eps). The ecofridge concept is an innovative design that allows both simple storage, easy-assembly and has none of the negative environmental and cost problems associated with current polystyrene boxes. Utilising eco-sound materials, innovative design and experience and skills of the consortium; the ecofridge project aims to address this issue and skills a pilot assembly plant to test the ecofridge and convert the current polystyrene users over to the environmentally sound cost-effective ecofridge alternative.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Assessing the Impact of Rural Development Policies' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The RuDI study will provide a thorough analysis of the design, delivery and impact of EU Rural Development Policy (incl. LEADER). The study combines quantitative and qualitative approaches starting with a critical review of the state-of-the-art in RD theory and the conceptual frameworks and approaches used in RD policy evaluation. In the study the Common Monitoring and Evaluation Framework (CMEF) and the underlying intervention and impact logics will be critically examined. The positive and negative effects of rural development policies on institutional, social, economic and environmental level will be identified and described in a set of carefully selected and framed case studies. The impact assessment will also include those impacts that have not been anticipated. The case studies will be representative of the structural differences that can be found in the characteristics of rural areas across the EU. Focus will be on different types and characteristics of territory, interrelations with RD programme priorities and measures, and an assessment of their &apos;hard&apos; and &apos;soft&apos; impacts. The comparative cross-national analysis of the case studies will provide a better understanding of driving forces in policy design, the strengths and weaknesses of different delivery and governance models, the positive and negative impacts of RD policies and, most importantly, a more convincing conceptual and methodological framework for evaluating RD policy. Consultations with RD policy actors and evaluators will ensure that the analyses are closely coordinated with the demands and possibilities of practitioners. The RuDI study will be concluded with recommendations for a more appropriate RD policy design, delivery, impact monitoring and assessment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mechanical Amplification in Carbon-based NanoElectroMechanical Systems' under Seventh Framework.

assistant: **Concept**

Nanoelectromechanical systems (NEMS) are very promising for sensing purposes, information technology, or exploration of quantum mechanics in extended bodies. A decisive parameter for any oscillator is the quality factor, Q, determining how much energy the system dissipates during one oscillation period. A high Q signifies large oscillator amplitudes and a sharp resonance. Although NEMS resonators display quality factors up to 10^6, their amplitudes are typically in the pm range or below, which makes the conversion into a readable electrical signal extremely challenging.Traditionally, the mechanical motion is immediately translated into an electrical signal, which is then amplified with high gain. Such electrical amplification creates an additional noise floor that limits the signal resolution even at cryogenic temperatures. To overcome this limit, we propose two stategies in order to enhance a mechanical signal before its conversion into an electrical current: parametric amplification (PA) and self-sustained oscillations (SSO).PA describes the augmentation of the amplitude of an oscillator by a periodic modulation of the spring constant. In other fields of physics and engineering, PA has already been studied and implemented, but suspended carbon nanotubes (CNT) and graphene strips appear especially promising since the spring constant of these oscillators can be tuned over a broad range by a backgate voltage.SSO describes in our context the creation of a high amplitude mechanical oscillation using a d.c. biased electron current as power source. These oscillations are expected to produce very sharp resonances with a high effective Q. Suspended CNT resonators are excellent candidates for SSO due to the strong coupling between the mechanical and charge degrees of freedom.On