RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mycobacteriophages to treat tuberculosis - Passed station or future promise?' (Phage-TB), addressing dissemination and exploitation.

assistant: **Impact**

The emergence of drug-resistance to tuberculosis (TB) drugs poses an increasing challenge to TB control and new treatment options are urgently needed. Novel or repurposed antibiotics are still being introduced, but this pipeline will dry out in the near future. Bacteriophages are viruses that kill bacteria. They have been used to treat infections before the introduction of antibiotics. With the emergence of drug-resistance there is renewed interest in this ancient treatment option. Clinical use of mycobacteriophages to treat TB and non-tuberculous mycobacterial (NTM) infections is still in its infancy. This project contributes to 3 areas in the development of clinically useful mycobacteriophage treatments for TB and NTM infections:- Phage discovery: From soil samples collected in the compounds of TB clinics and hospitals in Cape Town, South Africa, we will isolate mycobacteriophages using spot tests and plaque assays. DNA of newly discovered mycobacteriophages will be sequenced and during the return phase of this project I will select promising mycobacteriophages with lytic effect against TB or NTM infections, that can be used for development of phage cocktails for clinical use. - Phage inhalation method: the efficiency of phage treatment is dependent upon the phage concentration reached at the site of disease. Phages that can attack M tuberculosis have long tails which might be vulnerable to manipulation. We will optimize an inhalation method leaving the phages intact and functional.- Preparation for a clinical trial: an existing mycobacteriophage cocktail active against TB will be used for a first clinical study in humans to assess dosing, safety and efficiency. If our mycobacteriophage hunt is successful, and the translation can be made into purified and adequately d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'International Tax Coordination'.

assistant: **Concept**

As a result of globalization and the increasing interdependence of national economies, new possibilities and risks related to cross-border taxation arise for investors and governments. To minimize the risks and to support the possibilities, alternatives to national fiscal sovereignty, i.e. various forms of tax coordination on a bilateral or supra-national level, may be required. Within the joint exchange programme we want to provide answers to specific issues raised in the scientific and political debate on international tax coordination within an area where countries are striving for economic integration. The partners of the joint exchange programme have already done research on the topic of international tax coordination but there has always been a limited regional focus. The joint exchange programme should help to extend the scope of research activities and include so-called “third country” aspects. The overall topic of international tax coordination will be explored in four work packages: (1) Assignment of Taxing Rights and Taxing Powers, (2) Corporate Tax Consolidation Regimes for Multijurisdictional Companies in a Single Market, (3) EU Tax Coordination and Third Countries, and (4) Consumption Taxes and Double (Non-)Taxation - Issues, Consequences, and Possible Solutions.The transfer of knowledge between the EU (Austria, Sweden) and third countries (Australia, Chile) will be achieved by several instruments. During, before and after the research exchange, the seconded staff will be optimally supported: there will be activities organized by the home institution (e.g. round tables, presentations...) and the researchers will also be integrated to the activities at the host institution during their research stay (e.g. discussions, preparation of joint publications...).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Role of the transcription factor ChREBP and its associated proteins in the development and progression of NAFLD.' (LIPIDOLIV).

assistant: **Concept**

Changes in lifestyle have resulted in a dramatic epidemic of type 2 diabetes and obesity. Among associated complications, Nonalcoholic Fatty Liver Disease (NAFLD) is emerging as the most common chronic liver disease and is gaining increasing recognition as a component of the epidemic of obesity. NAFLD is generally asymptomatic, although a minority of patients may present progressive liver injury with complications of Nonalcoholic steatohepatitis (NASH), cirrhosis and HCC. Excessive accumulation of fatty acids (FA) stored as triglycerides (TGs) in hepatocytes is the hallmark of NAFLD, which is strongly associated with insulin resistance (IR). However, despite the existing correlation between fatty liver and insulin resistance, it remains unclear whether insulin resistance causes the excessive accumulation of TG in the liver, or whether the increase in TG itself or other lipid intermediates such as diacylglycerols (DAG) and/or ceramides may trigger the development of hepatic or systemic insulin resistance. While some studies support the concept that intrahepatic accumulation of lipids precedes insulin resistance, others suggest that hepatic TG may in fact protect the liver from lipotoxicity by buffering the accumulation of FA. Such discrepancy might be explained since different pools of lipids exist within cells and only certain pools regulate insulin signaling. Consistent with such hypothesis, recent results by our group strongly support that specific FA species may influence hepatic TG storage, insulin signaling and/or inflammation. Therefore, the global aim of our proposal is to better understand the regulation of hepatic fatty acid synthesis and partitioning in addition to its impact on the detailed lipid profile. Using state-of-art technology and key genetically modi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Real time analysis of tablet and capsule dosage during pharmaceutical manufacturing' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The objective of the overall innovation project is to develop a novel instrument to measure and control pharmaceutical drug potency during manufacture at sub-second analysis speeds.  This will significantly reduce the cost of quality testing, reduce the dosage variability that a patient receives, reduce production waste and solvent disposal and address challenging new regulatory testing guidelines.Pharmaceutical companies, in response to regulators (such as the US FDA) setting direction and guidance, need to better understand and control their processes.  Real-time release testing (RTRT) and Quality by Design (QbD) are promoted by regulators as their vision of where quality must go; pharmacopeia guidance supports that vision.  Cobalt has developed a successful, patented, high speed quantitative analysis technology called transmission Raman spectroscopy (TRS), which measures drug potency of intact tablets and capsules.  When used during production (“on-line”) in combination with an automated physical tablet testing system, TRS will enable immediate release of drug product without “off-line” analysis in a quality control (QC) laboratory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Money, Rituality and Tombs in northern Italy during Late antiquity' under Horizon 2020.

assistant: **Concept**

Placing coins as grave offerings was one of the most common, and is among the most widely studied, funerary pagan practices in the Roman world. Charon’s obol was the toll that souls had to pay to be ferried to the netherworld. The deposition of coins in tombs did not cease with the Christianisation of the Roman world, and the extension, prevalence (in terms of geographical areas, types of burial, etc.) and meaning of this practice during the Middle Ages are unclear. The main aim of MORTI is to interpret the use and meaning of coinage in post-classical funerary practices through its full archaeological contextualisation and the study of its relationship with the personal traits of the individuals they were buried with (sex, age, social and religious affiliation, etc.). Northern Italy is an ideal region where to carry out this project; it is no only a key region to understand the transformations undergone by the Mediterranean world after the fall of the Roman Empire (militarisation of society and settlements, Gothic and Lombard kingdoms, the struggle between Arrians and Catholics, commercial exchange, etc.); it has also been subject to specific studies about post-classical funerary practices (CAMIS, CARE) leading to over 15,000 data entries that are of interest for the project. MORTI will use this record and statistical multivariate correspondence methods to analyse circa 800 coins from over 120 necropolis dated to between the 3rd and 11th centuries. This analysis will specifically examine the phenomenon of Charon’s obol, and more broadly the characteristics of funerary ritual and the evolution of post-classical mentalities over time. MORTI will create new links between numismatics and funerary archaeology, as well as opening a wide array of research and professional aven
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Datamining file server' (DAFS) under Fourth Framework.

assistant: **Objectives**

Data mining is a technique for examining very large databases to help discern subtle relationships suggesting new business activities that need increased or decreased investment. The project aims to enhance the performance and functionality of data-mining systems by building a special purpose parallel data-mining server and an associated front-end client. This will be achieved by: - Building a parallel data-mining client server product with scalable high performance;- Adding value by improved functionality and cost performance;- Satisfying the data-mining needs of the data-dependent industries.The main technical innovation is the implementation of current and emergent data-mining technology and associated database techniques on a CPU intensive server running on the PARSYS parallel platform. Large volumes of data, too great for analysis, have been a major problem for end users. The results of this project will make it possible to search and analyse these very large databases in order to find information important to the competitiveness of many organisations. http://www.parsys.comhttp://www.trans.net/dafs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Emigration of High-Skilled Individuals due to Short-Term Contracts' (EXODUS) under Seventh Framework.

assistant: **Objectives**

This proposal presents a study of the EXODUS of exceptionally gifted individuals due to the increased utilization of short-term contracts. The primary objective is to study the impact of Italian labour market reforms, specifically those related to the regulation and utilization of short-term employment contracts, on the departure of skilled workers towards other countries, which typically offer more and better opportunities (brain drain).Theoretically, the utilization of short-term contracts could help increase labor force participation, employment, efficiency and labour market opportunities. However, if not regulated in integration with the specific institutional framework, short-term contracts might generate undesired effects. By promoting adverse selection, driving the better workers away from the mother country as the less productive workers take up short-term contracts, short-term contracts might actually increase the brain drain. The purpose of EXODUS is to investigate the validity of these concerns and to analyze the way short-term contracts affect the brain drain phenomenon. In particular, EXODUS will focus on investigating the employment condition and behavioral choices of a specific category of workers: young individuals with a high level of education.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Human Capital Accumulation in Developing Countries: Mechanisms, Constraints and Policies' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

We propose to study the process of human capital accumulation during the early years of life in developing countries. The research is motivated by the importance of early years to human development, both because of the long run consequences of events during that period and because of high malleability across key developmental domains during that period, making it particularly salient for policy interventions. The research is organized into three parts. First, we need to understand the process of formation of human capital, what economists refer to as the production function of human capital. Human capital is understood as a multidimensional object whose components (cognition and intelligence, socio-emotional skills, health) evolve in a complex way interacting with a variety of inputs and environmental factors. Disentangling the role played by different factors and inputs (including initial conditions, environmental shocks, parental inputs, centre based care) is important for our understanding of the process and for policy analysis. Second, we need to understand parental behaviour, as parents choose many of the investments in human capital development. Many questions are open: what are the constraints (resources, information, beliefs and attitudes) that parents face in making investment choices? Do parents make optimal choices? Do parents reinforce or compensate shocks? How are resources allocated across children of different gender and/or ability? Who makes decisions within the family? Third, measurement and the design of measurement tools is central to our research. We need to examine the performance of existing measurement tools and propose, design and validate new ones. The research, led by an economist, is interdisciplinary, using inputs from psychologists, child de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Safeguards R&D' under Sixth Framework.

assistant: **Concept**

Specific Objectives 8.2.1.1. Improvement of Measurement Techniques and Methods Comparative evaluation of calorimetry and NCC for small Pu samples Improvement in U and Pu assay using ID-MGA Improvement of spectrum analysis for HKED-XRF Study the use of room temperature detectors in COMPUCEA Experimental validation of minor actinide analysis by NCC, GS, XRF Modified HKED with extended XRF measurement capabilites (elements down to Z=35) Development of analytical methods for specific types of samples (e.g. advanced fuels) Development of mass spectrometric technique for Np/Pu ratio measurement Development of replacement code for MGA 8.2.1.2. Microparticles and IC-ICP-MS for Safeguards integration of software and hardware for SIMS automation production of PuO2 particles GDMS for wide area monitoring Np, Pu/Am fission tracks/TIMS round robin (RR) IAEA SIMS sample preparation IC-ICP-MS for hote cell swipes/Np and actinides support IAEA 8.2.1.3. Analytical Services and Analytical Support In Determination of U and Pu concentration and the isotopic abudances in unirradiated samples using NDA and DA analytical techniques Miscellaneous physical and chemical measurements Trace analysis by ICP-MS for concentrations of impurities Uranium isotopic abundances in swipe samples using SIMS Determination of C-O-N-H, O/M, Cl, F in unirradiated samples Implementation and quality assurance of accredited methods (ISO 17025) Training of operators in the analytical techniques implemented Support to LIS Test, validation and maintenance of the Compucea device, measurements and software Infield measurements of samples. Training of analysts (ITU, ESO and IAEA) 8.2.1.4.Nuclear Forensics Science Development of the microstructural fingerprint Research on the seized materials available Dating of seized il
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Assembly Lines for Biocombinatorial Chemistry' under Horizon 2020.

assistant: **Concept**

Polyketide Synthases (PKS) are biological factories for the production of potent natural products, including antibiotics, anti‐cancer drugs, statins and further drugs. The exceptional chemical diversity generated by PKS is encoded in their modular architecture. The domains required for one step of precursor elongation and modification are combined into a functional polypeptide module. PKS modules can either act iteratively (iPKS) or in a linearly organized assembly line of multiple modules (modPKS). The collinearity between synthesis and protein sequence in modPKS promised the opportunity for rational re‐engineering of PKS at the genetic level in order to produce novel compounds. However, information on functional protein-protein interactions and substrate transfer in PKS beyond the level of isolated domains is sparse and divergent architectural models of module organization have been proposed. In the AL2BIOCH project, we aim to reveal the fundamental intermodular assembly line organization underlying the unique biosynthetic generation of chemical diversity by modPKS. For this purpose, we employ cryo-electron microscopy to comprehensively study the organization of modPKS bimodules as minimal representations of assembly lines organization. In combination with functional analysis, biophysical studies and chemoenzymatic trapping we address the architectures underlying directed substrate transfer. The research builds on modern and rapidly evolving techniques, including cryo electron microscopy, advanced optical imaging and biophysics, as well as chemical probes, which are most relevant for front-line molecular biology research. Success in this project will allow the host lab and organization to establish new collaborations for translating insights on modPKS architecture for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Search, Challenge, Fight, Care, Rescue for Lives.' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The 5-LIVES project has its foundlings and justifications on the benefits that rotorcraft industry can obtain by the exploitation of European Satellite Navigation services within operations performed by helicopters, and in particular under distress or danger situation where life is in risk. The 5-LIVES projects aims to work out into the following areas:• Helicopter Visual RNAV with EGNSS: The 5-LIVES project proposes to extend the Visual RNAV concept (under development at ICAO level mainly for fixed-wing) to the rotorcraft operations, so this segment can also take real benefit of new GNSS technologies.• Helicopter IFR procedures: The 5-LIVES project aims at working into the enablers related to installation and certification of the equipment and also the procedure design and validation.• Advanced curved trajectories for constraining environments: The 5-LIVES project aims to demonstrate the technical feasibility of such concept. Today, there is no procedure with such characteristics available for helicopters worldwide, which represents a clear challenge• Galileo guidance for Unmanned Air Vehicles: The 5-LIVES project aims at performing the first Search and Rescue demonstration based on a UAV guided by Galileo and EGNOS.• Accurate positioning for ground emergency management: the 5-LIVES project will extend the use of EGNSS by upgrading the current firefighting monitoring system that today uses GPS only.Previous European initiatives were mainly focused on the use of GPS and EGNOS for Helicopter instrument flight procedures. Although 5-LIVES also covers this user segment, the project is also including activities that will help to promote the use of EGNSS also for non-certified IFR helicopters,  which represent the great majority of the helicopter fleet. The overall project o