RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced Pain Control – An innovation in pain control for those suffering from secondary bone cancer' under Horizon 2020.

assistant: **Concept**

This Phase 1 project will enable Scandinavian ChemoTech AB (ChemoTech) to develop a business plan for Dynamic-ElectroEnhanced Pain Control (D-EEPC). This will include clinical and market feasibility, with a strong business development and commercialisation strategy. Approximately 25% of all cancer patients are affected by secondary bone cancer; which is difficult to find and treat. 20-30% of these patients do not respond to current systemic therapies and pain control with narcotic analgesics, radiation therapy and surgery. This patient population continues to experience potentially debilitating back pain. To address this, ChemoTech has developed D-EEPC - a game-changing pain reduction treatment for secondary bone cancer. It operates by sending short, high voltage electric pulses in combination with a low concentration of a cytostatic drug to reduce tumour size in the spine or bones. This reduces pain caused by pressure on nerves. The different voltage settings and use of an applicator with different sizes allows treatment of hard-to-treat cancers and distinguishes D-EEPC from its competitors. Development of D-EEPC and research supporting its efficacy and safety to date is extremely promising but requires full clinical validation and an optimal business strategy. The proposed Phase 1 project will enable the company to define the pathway to implement for successful commercialisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'COVID-19 ICU-CARE – A ground-breaking ICU bed-side COVID-19 trachea flushing system that can cut healthcare costs and reduce COVID-19 spread between ICU patients and staff' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

When the severely ill COVID-19 patients are admitted to the Intensive Care Unit (ICU) for respiratory support (breathing with the support of a mechanical ventilator), it is crucial that the upper airways of these patients are being suctioned many times daily to remove secretion and mucus, in order to prevent lung infections. If not removed efficiently, there is >50% likelihood of mortality. Unfortunately, the suctioning techniques today have 2 major limitations 1) it cant remove secretions efficiently and thereby preventing lung infections and 2) it induces a very high risk of COVID-19 spread amongst ICU patients and staff, as secretion is suctioned outside the patients body.AW Technologies aims to solve these problems with TrachFlush – a patented suctioning assist system. As an add-on to standard mechanical ventilation systems used in the ICU, TrachFlush automatically flushes ALL secretion out of the airways and has already shown to cut cost and to reduce contamination in a small feasibility study on general ICU patients.The aim of this project is to take TrachFlush to market and battle the COVID-19 outbreak. In collaboration with experts from 5 leading hospitals from Denmark, Italy, Holland and Spain, this COVID-19 ICU-CARE project concerns a large-scale clinical study to reach TRL 8 and aims to demonstrate: 1) a 90% efficient secretion removal and implicit reduction in lung infections, 2) a 90% reduction in ICU nurse workload and, 3) elimination of any contamination between patients and staff – on COVID-19 patients! When we reach these goals, we can help EU battle the COVID-19 outbreak. The business opportunity is huge. Our market is €3,6Bn and will reach €4,5Bn by 2025. Via a recently signed distribution agreement with an ICU ventilator manufacturer, we aim for rapi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Proteome-guided CRISPR identification of insulin sensitivity mediators'.

assistant: **Concept**

Type 2 diabetes (T2D) is a growing global health epidemic. Insulin resistance promotes T2D, adversely affecting human health, increasing the risk of all-cause mortality, and generating an enormous socioeconomic burden. Skeletal muscle is the major tissue responsible for blood glucose lowering effects of insulin, and thus insulin resistance in this tissue is a primary driver of disease pathology. Exercise is an effective intervention for skeletal muscle insulin resistance, promoting glucose uptake and enhancing insulin sensitivity. However, patient adherence to exercise regimens is low and no T2D therapies directly improve skeletal muscle insulin action. Understanding protein and signaling events that mediate insulin and exercise induced glucose uptake in skeletal muscle is vital for identifying therapeutic targets for insulin resistance and T2D. PRISM aims to identify clinically relevant targets for insulin resistance in skeletal muscle and assess their involvement in regulating glucose uptake. To achieve these aims, I will combine omics, cell biology and physiology approaches. Large-scale protein and signaling analyses of human skeletal muscle in basal, exercise and insulin-stimulated states will be comprehensively integrated with clinical phenotyping to identify therapeutic targets. The function of identified targets in insulin stimulated glucose uptake will be assessed with state-of-the-art CRISPR screens and cell biology approaches. Finally, the physiological role of select targets will be assessed using an innovative and rapid CRISPR knockout animal model. This MSCA has the potential to make a breakthrough in clarifying underlying mechanisms of insulin and exercise signaling, providing insights into novel drug targets for treating T2D.


**Keywords:** Insulin signa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transfer of Multimaterial Flexible Packaging to Circular Economy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

On January 16, 2018 the first-ever European Strategy for Plastics in a Circular Economy has been published. The Commission strives for solutions to get all plastic packaging recyclable by 2030. FlexPack2Circle is a timely action to address the EU directives to stop incineration and landfilling and to recover secondary raw materials. Saperatec is worldwide the first company offering a holistic approach to transfer flexible packaging waste (FlexPack) into the circular economy by a breakthrough technology to recover ALL materials of multimaterial laminates. The patented technology separates PE/aluminum/PET composites in a gentle way without material loss receiving high purity materials. For its innovative approach Saperatec has been awarded with several prizes, such as the Greentech award, Europe’s most renowned environmental and business prize. During FlexPack2Circle the pilot line proven processes will be transferred to industrial scale resulting in a 1st unique recycling plant with a capacity of 18.000 t/a.  The business and commercialisation plans are finalized. On short-term Saperatec focuses on the recycling of post-industrial waste from the packaging industry, the market of which is with 400.000 t/a large enough to start the business. More than 200% of the annual yearly plant capacity are already secured by LOIs from potential infeed and outbound customers. The Saperatec business is high risk due to the large capital investments needed. However, currently Saperatec is in the final phase of term sheet preparation with the investors. With the support of the European commission Saperatec is able to accelerate the upscaling and to keep R&D and pilot line activities on high level to further upgrade the material quality, to develop a new packaging design with compatible a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Multi-focal scanning plasmonic nanoscope for super resolution imaging of living cells'.

assistant: **Objectives**

This project aims to design the first ever prototype of a plasmonic microscope for in vivo bio imaging. The principle behind the prototype consists in deep sub-wavelength focusing and raster scanning of multiple points to achieve imaging. On the one hand, using surface plasmons excitation for microscopy instead of light offers the advantage of ultra short plasmonic wavelengths (down to 100 nm) for visible light frequencies, enabling a plasmonic diffraction limit of 50 nm which sets the resolution of the microscopy. On the other hand, in this ultra short wavelength regime surface plasmons suffer losses, limiting the propagation length of plasmon waves. Losses limit the image size (field of view) to no more than 10 by 10 resolution points, a size which is completely insufficient for biological samples. The main scientific challenge of this proposal is to surpass the plasmonic losses which constitute a limitation for microscopy and most plasmonic applications. While previous attempts were based on reducing the losses (succeeded up by a factor of two), we propose a scheme that is not sensitive to these losses. The scheme consists in a ""network"" of periodic plasmonic repeaters that regenerate the lossy signals, similarly to the standard method used for distributing cellular phones and TV/radio signals over long distances. In particular, we will use a Spatial Light Modulator (SLM) to create and scan multiple plasmonic foci in parallel. The image is acquired via raster scanning of all the plasmonic foci in parallel, yielding an image size limited only by the extension of the network, namely the number of pixels in the SLM. Moreover, this scheme also reduces the scanning time by up to two orders of magnitudes, making it suitable for in-vivo measurements.In conclusion, we prop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'New Hybrid Thermoplastic Composite Aerostructures manufactured by Out of Autoclave Continuous Automated Technologies'.

assistant: **Objectives**

NHYTE project aims at developing and demonstrating concepts and methodologies enabling the realization of innovative integrated aero-structures, made of a new hybrid thermoplastic matrix composite material with multifunctional capabilities. The high-performing material proposed, based on a commercial PEEK-Carbon Fiber Prepreg with addition of amorphous (PEI) films, answers to the needs to have reduced weight and consequently reduced fuel consumptions and emissions on an aircraft, as well as reduced manufacturing and operational costs. Demonstration aero-structures will be fabricated by an innovative working cell implementing an advanced continuous automated production process, including: automated hybrid material fabrication; manufacturing of skin panels by automated fiber placement in-situ consolidation process; fabrication of stringers by continuous forming; component assembly by induction welding. The innovative material, conceived and patented by a partner of the Consortium, is an example of multifunctional composite, since it returns both functions of toughness improvement (multilayer material) and process simplification. This concept on one side will provide an advantage from the structural point of view, in terms of better impact damage performance; while on the other side major advantages will result on processing simplification, in particular including improved cycle times and lower energy consumptions, since it does not require the use of an autoclave curing phase. As of today, its usage has been limited to fabricate panels, only at laboratory level; hence, a suitable improvement finalized to process in industrial environment is needed. Proposed process techniques and assembly will be the first step towards the industrial application of the innovative material
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Delivery of liquid Hydrogen for Various Environment at High Rate' under Horizon Europe.

assistant: **Concept**

Liquid hydrogen is a key solution to enable strong carbon reduction for energy, chemical and mobility industries. If technologies are mature for light vehicles fast refuelling, it is still a challenge for heavy duty applications, hampering massive environmental gains for aviation, maritime, railroad.DelHyVEHR offers to fill the gap of liquid hydrogen distribution technologies by driving the maturation to the demonstration at TRL 6 of the large-scale refuelling station and each main systems with a specific focus on pumping, metering, loading and boil-off gas management systems.DelHyVEHR main objectives are to: •Develop a high flowrate (>5 t/h and up to 6 t/h) transfer cryogenic pump for LH2 refuelling stations with high efficiency (>60%) and high reliability (Mean Time Between Maintenance > 3000h)•Develop and adapt loading and dispensing systems for the high-flowrate refuelling station•Develop and optimize a boil-off gas management system enable to recover >80% of the hydrogen•Design, build and operate the LH2 refuelling station to refill a cryogenic storage of 4-6 m3 and with integrated technologies demonstrated over long-time operation (>10 h)•Assess economic, environmental impacts and policy suitability of the technologies and demonstrator with expected cost reduction of investments and operation of LH2 bunkering stations at 1.5 €/kg and deliver H2 carbon footprint aligned with RED II legislation below 3.38 kgCO2/kgH2•Ensure safety of the LH2 bunkering station and its operationDelHyVEHR demonstration before 2027 will enable commercialisation before 2029 to target 15 refuelling stations in 2030 and up to 81 stationsin 2040 for shipping, aviation and railroad markets.To succeed, DelHyVEHR gathers 13 EU leading partners covering the whole value chain from component devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Integrated genomics, clinical research and care in hypertension' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The InGenious HyperCare Network of Excellence's goal is that of integrating complementary but still fragmented experience in the mechanisms of blood pressure control and hypertension development, in phenotyping initiation and progression of organ damage and exploring genetics, genomics and proteomics of proneness to hypertension and hypertension-related cardiovascular disease. A better prevention of hypertension and its cardiovascular consequences is an essential public health goal in Europe, where cardiovascular diseases are the major cause of mortality and morbility. The Network plans to integrate the research efforts of 31 research teams (including a SME) and 1 SME experienced in EC project management. A powerful instrument of integration will be the Programme of Joint Research Activities. A first group of research packages will be addressed to Mechanomics of Hypertension, i.e. identifying genetic, genomic and proteomic markers of disturbances in the major mechanisms (autonomic control, inflammation and oxidative stress, sodium handling) controlling blood pressure, as indicators of the risk of becoming hypertensive.The second group of research packages will be addressed to Mechanomics of Hypertension-Related Diseases, i.e. identifying the genetic, genomic and proteomic markers of the risk of developing a hypertension-related event (stroke, renal dysfunction, heart failure). Through these activities the Network will build up large integrated platforms of common phenotypes, genotypes and proteomic data in hypertensives, and assemble unique sets of comprehensive databases. Spreading of excellence beyond the Network will be done with the support of the European Society of Hypertension.The activity of the Network will continue after end of the EC funding, with the objecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Statistical multi-Omics UNDerstanding of Patient Samples'.

assistant: **Innovation**

Bioinformatic analysis is the biggest bottleneck in many genomic medicine projects. Our objective is to enable researchers to dramatically increase statistically informed use of personal multi-omic data in medicine. Soon, multiple types of omic technologies will be applied to 100,000s of patient-derived samples, with the three-stage goal of better understanding disease biology, discovery of new interventions, and personalizing the choice of treatment options. Our interdisciplinary team of biostatisticians, bioinformaticians, software developers and physician-scientists will address the analysis bottleneck with statistically and computationally sound methods. The SOUND consortium will (i) develop widely used and excellent bioinformatic and statistical methods and open source software for common but challenging tasks, including data pre-processing, data integration, statistical inference, visual presentation, and publication-quality reporting; (ii) introduce novel approaches to ground breaking multi-omics applications in oncology and medical genetics; (iii) develop interoperable data structures and software interfaces that enable seamless combination of tools; (iv) support a collaborative international academic and industry developer community; (v) enable rapid development and execution of high-quality software; (vi) lower the barrier to entry into this transdisciplinary field by providing simple, robust, easy-to-use solutions; and (vii) develop a training programme with regular courses and comprehensive online tutorials. Our aim is to create the de facto standard toolkit used in every clinical research lab for statistically informed analysis of personal multi-omic data. SOUND will increase research and innovation opportunities by reducing barriers of entry to genomic med
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Animals, Livelihoods and Well-being in Africa'.

assistant: **Concept**

Animals are central to the livelihood strategies of millions of people in sub-Saharan Africa. Across the continent, animals provide sources of food and income, despite the growth of more diverse modes of subsistence. However, entanglements between humans and animals often have deeply problematic consequences for health, well-being and the environment. For example, unsustainable hunting practices reduce biodiversity and risk zoonotic disease transmission, and the uncontrolled use of antibiotics in intensified farming threatens to exacerbate anti-microbial resistance. Meanwhile, against a backdrop of climate-change induced pressures, development projects try to change human-animal relations in order to enhance productivity and economic resilience. Within this emerging dynamic it is important to reappraise the role of animals for contemporary livelihoods; the implications of human-animal relations for the wellbeing of multi-species communities; and the mechanisms of governance that seek to manage human-animal relations. This will be achieved through detailed ethnographic case studies in Kenya and Sierra Leone. This approach will shed light on contemporary livelihood strategies in sub-Saharan Africa. It will enable a major innovation in the social sciences by pushing forward new, post-human, visions for the fields of development and global health. Moreover, these local studies will be situated in a global context through a study of global assemblages of animal-focused development and One Health approaches. A deeper understanding of human-animal relationships has important implications for sustainability across species and will help to shift thinking around health and livelihoods in Africa from an anthropocentric perspective towards a post-humanist vision that enables multi-