RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Interaction between predictable" and "unpredictable" stress with antidepressant drugs in different behavioural responses relevant in depression"'.

assistant: **Objectives**

Stressful life events are known to be among the causes of depression. Exposure to stressful stimuli can disrupt a variety of behavioural responses which can be restored by antidepressant treatments, and this phenomenon is the basis of most animal models of depression. However, exposure to stress can also induce effects similar to treatment with antidepressant drugs. A crucial element in determining the direction of stress effects (i.e. either depressive-like or antidepressant-like effects) appears to be predictability. Experimental evidence indicates that the mesolimbic dopamine system plays a role in the ability of the CNS to respond in opposite ways to stress. The aim of this project is to compare the effects of predictable and unpredictable stress, and their interaction with treatment with antidepressants, in different behavioural responses which are relevant to depression, including two responses which are mediated by the stimulation of dopamine receptors in the mesolimbic system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'TGF-beta signaling in colorectal cancers'.

assistant: **Concept**

Colorectal cancer (CRC) is a leading cause of cancer-related death in western countries. TGFb are a family of signaling molecules delivering crucial tumor-suppressive signals to different cell types. Lack of TGFb induced cytostasis is a hallmark of cancer, and mutations of key transducers of TGFb in Colorectal cancer (CRC), albeit found only in a subset of tumors, indicates a leading role for these signals in limiting tumor progression. In our lab we identified Ectodermin, a molecule that antagonizes TGFb responses by controlling Smad4 ubiquitination. Interestingly, Ectodermin is expressed in the normal and neoplastic human colon, and it plays a causative role in limiting the anti-mitogenic effects of Smad4 in tumor cells. Our preliminary data point at a fundamental role of Ectodermin in vivo as Smad4/TGF-b inhibitor, both during embryonic development and for adult tissue homeostasis. We propose here to exploit the genetic inactivation of Ectodermin in models of CRC progression to test if raising cellular responsiveness to tumor-suppressive signals (i.e. by disabling a key endogenous inhibitor) can oppose tumor formation/progression. Moreover, as part of the previous Marie Curie Fellowship to the applicant, we recently characterized the function of a novel Smad4 deubiquitinating enzyme (SADE), required for TGFb signaling, opposing Ectodermin functions in multiple cellular and development systems. We propose here to test the potential role of SADE as tumor-suppressor in CRC and to develop genetic tools to study the function of SADE in mammalian tissue homeostasis. This approach has the potential to generate novel genetic models of CRC, and to open the way for new avenues of therapeutic intervention targeting these novel enzymatic ‘druggable’ targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Optimising strategies for the detection of gene-nutrient interactions in the aetiology of colorectal neoplasia: an ecp consensus-forming workshop.' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

We are offering to organise a consensus workshop focussing on links between intakes of nutrients and foods and colorectal cancer, and its precursor lesion, the colorectal adenomatous polyp, and how these are mediated by genetic factors influencing metabolism. More precisely, evidence and approaches to investigating the relationship between genetic variability and specific biomarkers of metabolism of nutrients and foods and have DNA hyper- and hypo-methylamine and DNA stability will be considered. The working method will involve intense individual preparatory work, focused consensus-forming discussions, and rapid dissemination of the results. The latter, while contributing to the awareness about thematic priority 1.3.3 of the work programme, will support and promote the successful design and submission of European-wide integrated research projects in this important field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'OPERATION AND MAINTENANCE AND GRID FRIENDLY TOOLS AND SOLUTIONS FOR SOLAR DATA FUSION AND INSIGHT EXPLOSION FOR RELIABLE, BANKABLE, CIRCULAR PV PLANTS'.

assistant: **Objectives**

SUPERNOVA will embrace existing proven successful concepts (breaking silos and innovating in sector where R&D&I are usually not a common target) and will integrate them with further disruptive key elements:- O&M and grid friendly design of PV plants thanks to advanced solutions in software for the early design and engineering phase to go beyond yield maximisation. Severe weather events are increasing in frequency and bespoke planning and dedicated mitigation measures must be put in place; - Multilayer approach where standalone solutions can be hybridised and connected in interoperable digital platforms;- Avoid a data tsunami effect on stakeholders by leveraging on AI to manage and govern the immense quantity of data and provide solutions using Instruction Tuned Large Language Models;- Share data with a larger basis to generate value for the data provider and for the data user and study how the process could be also monetized;- Develop solutions related to the use of automated processes that can replace the operator's work in data and image collection, increase the intrinsic value of O&M contracts, free up human resources for data analysis itself and therefore the creation of added value in new services ; - Develop solutions that exploits all the previous key elements towards condition monitoring of PV components in view of circular economy (for e.g., reuse), drive optimal procurement for future projects, provide valuable insights for better services (for e.g. insurance) and ultimately increase profitability.Combining these features SUPERNOVA will innovate in: O&M and grid friendly design including mitigation measures for severe weather conditions, tools and components for multi aspect sensing, robotic solutions and their hybridisation, data fusion to generate AI based c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Role of neurosteroids in a novel mechanism modulating the nociceptive system through ATP and GABA receptors' under Sixth Framework.

assistant: **Concept**

Nociceptive stimuli are essential in maintaining the integrity of an organism. Certain diseases however generate chronic, pathological pain, which is detrimental to this integrity. P2X ATP receptors are involved in the initiation and transmission of nociceptive signals in peripheral tissues. The host laboratory showed that P2X receptors, as well as GABAA receptors, are involved in a new mechanism modulating nociceptive signals in the spinal cord and that their function can be affected by neurosteroids, a class of steroids produced in the nervous system.This project aims to(1) Determine the exact nature of the endogenous neurosteroids involved in nociception and their site of production(2) Define both the acute and chronic action of these neurosteroids on nociceptive neurotransmission(3) Determine the nociceptive neuronal subpopulations affected by these neurosteroids(4) Evaluate the role of neurosteroids in the generation of pathological pain in disease statesWe will use a multidisciplinary approach including morphological, electrophysiological and molecular methods applied to in vitro and in vivo models of inflammatory or Neutrogena pain. The results of this project will improve our comprehension of the generation of pathological pain and define the role of neurosteroids in the initiation and maintenance of pain. The neurosteroid modulation mechanism of nociceptive signalling will provide targets for new and innovative therapeutic strategies of chronic pathological pain management that avoid side effects such as addiction and tolerance. This project relies on the synergy of the competences of both the fellow and the host laboratory. It will result in a two-way knowledge transfer that will enhance both the career prospects of the fellow and the scientific excellence of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Palm hydraulics linking biodiversity and functioning of tropical forests under climate change' (PalmHydraulics), addressing dissemination and exploitation.

assistant: **Impact**

How do biodiversity and ecosystem functioning respond to climate change? Currently, fundamental knowledge gaps prevent us from answering this most pressing question. Global climate is largely dependent on tropical forest functioning due to the scale of plant-driven ecosystem services that they provide (water and carbon cycling). Thus, research on tropical plants is essential to address the question. However, critical plant groups such as palms, which are hyperdominant in tropical forests, remain almost entirely neglected. The intricate relationship between plants and the environment is mediated by functional traits, but current models do not yet account for the dynamics of species and functional composition and thus fail to predict plant/climate responses accurately. This critical knowledge gap is the primary focus of PALMHYDRAULICS. The project will use palms as a model group to explore hydraulic traits, which are pivotal in plant/climate responses, but unstudied in palms, despite their importance. PALMHYDRAULICS will focus on the structure, ecology and evolution of palm hydraulic functioning. Through a novel, integrated research programme, PALMHYDRAULICS will use cutting-edge analyses to disentangle the role of trade-offs in plant hydraulic structure relating to species diversification, intraspecific variation, structural development and individual survival that underpin feedback mechanisms between plant effect on and responses to climate change. This comprehensive, ambitious approach builds on the world leadership of the host institution in integrated studies of the palm family, plant morphology and evolution, its unrivalled collections, and the complementary expertise of the host scientists and experienced researcher. Novel and extensive datasets will be produced an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Smart and reliable solid biofuel quality control solution'.

assistant: **Concept**

The goal is to realize the global market opportunity related to a disruptive real-time solid biofuels quality control and optimization solution created, tested and proven by INRAY Ltd in cooperation with industrial anchor customers since 2009. The innovation enables biomass power plants to replace the current manual sampling method by real-time assessment and optimization of fuel handling and combustion, producing concrete value and savings both to a vast body of industrial customers and the society at large. For the entire EU’s bioenergy production, the OPTIFUEL solution could produce 1.5 Billion Euros in annual savings and decrease greenhouse gas emissions by 0,5-3,0 Million tons. OPTIFUEL also enables more effective use of local low quality biofuels, which would increase EU’s self-sufficiency in biofuels. For a mid-size biomass power plant, OPTIFUEL produces up-to 1 Million Euros in annual savings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Higher dimensional dynamical systems and entropy balance'.

assistant: **Objectives**

I have been acquainted with László Mátyás since 1997 when he came to our institute from Transyvania (Romania) as a young physicist and Ph.D. student. I became his advisor. He is well educated, has a broad and up-to-date knowledge in the fields of thermodynamics, statistical physics and dynamical system theory. He is a very careful thinker which is illustrated, among others, by his research on the concept of entropy production in maps. By now he has become an expert in modeling transport processes by simple dynamical systems. He is capable to clearly formulate problems, to concentrate on important questions only. Both in teaching and in research Laszló Matyas has always shown outstanding qualities. Due to this fact he has belonged to the best students (10%) in comparison with other students who have equivalent training. I believe that the professional Qualifications of the applicant combined with his personal properties can guarantee full success in his future scientific activities. In conclusion, Laszlo Matyas is a talented young physicist whom I recommend warmly for a Marie Curie fellowship.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quantum Sensing for Biology' (QSB).

assistant: **Concept**

Modern physics has contributed to the development of powerful instruments and diagnostic tools for biology and medicine, with a direct impact on both our well-being and life expectancy. Today, it is timely to ask if the novel field of quantum information is ready to provide new methods for the life sciences. This proposal makes a step in this direction, introducing non-invasive quantum techniques for experimental biology, with potential applications to biomedical imaging. My goal is to show how quantum correlations (entanglement or discord) can be exploited to realize a fully non-invasive form of spectroscopy, which can be safely applied to fragile materials, such as photo-degradable biological samples (DNA/RNA) or in-vivo human tissues. These objectives are not met in today’s biology labs, where UV-light photometry heavily damages DNA/RNA samples, or in public hospitals, where X-ray scans expose patients to significant radiation doses, with non-negligible risks of cancer. The basic rationale behind the use of quantum correlations relies on their superior capacity to detect small variations in the absorption properties of the materials, even when only a few photons are employed. By exploiting this remarkable feature, I will prove the possibility of non-invasive testing of biological samples. My central task will be the design of a practical model of a quantum-enhanced photometer which is fully based on continuous-variable systems. This design will involve the extension of quantum sensing and metrology to a more advanced double-box formulation where two channels, representing seeded and blank samples, are simultaneously probed. The realization of such a quantum-enhanced instrument would allow for real-time continuous measurements of organic molecules and nucleic acids wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Active tactile exploration - How specific morphologies and mechanosensory structures lead to functionally useful sensing in both biology and artificial systems' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Navigating over complex and varying terrain is a fundamental challenge that animals tackle with ease, but even state-of-the-art robots struggle to achieve. Reverse-engineering animal sensorimotor control and active tactile sensing can provide crucial insights for designing autonomous robots and smart prosthetics. Unraveling these mechanisms is challenging because neural processing via mechanosensors and body structures (known as morphological intelligence) are tightly coupled. This project will study how animals gather information about the environment through touch, using Drosophila. In particular, it will uncover how leg mechanosensors and leg morphologies work together to enable robust tactile exploration. First, I will identify which leg mechanosensors and segments enable flies to detect and navigate obstacles. By quantifying 3D limb kinematics during obstacle encounters and using optogenetic activation of specific mechanosensory neurons, I will reveal how individual sensors and leg mechanics drive real-time obstacle detection and avoidance. Second, I will elucidate how mechanical interactions are encoded in neuronal activity. By recording population activity of mechanosensory neurons using two-photon calcium imaging during controlled mechanical stimulation, I will uncover how the spatial arrangement and co-activation of leg bristles encode tactile information. Finally, to evaluate how mechanosensor morphologies and arrangement enhance tactile sensing, I will fabricate artificial mechanosensors to systematically compare configurations and reveal how sensor geometry and alignment improve spatial and directional encoding. This project will pioneer a new understanding of how morphological intelligence contributes to environmental sensing and navigation. It will advance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Human-guided collaborative multi-objective design of explainable, fair and privacy-preserving AI for digital health' (HarmonicAI).

assistant: **Concept**

Artificial Intelligence (AI) is one of the most significant pillars for the digital transformation of modern healthcare systems which will leverage the growing volume of real-world data collected through wearables and sensors, and consider multitude of complex interactions between diseases and individual/population. While AI-enabled digital health services and products are rapidly expanding in volume and variety, most of the AI innovations remain in the form of proof-of-concept. There is a continuous debate regarding whether AI is worthy of trust. The EU AI HLEG has defined that trustworthy AI systems should be lawful, ethical and robust. To translate it into actionable practices, provision of explainability, fairness and privacy is crucial. A considerable volume of research has been conducted in the areas of explainable AI, fair AI and privacy-preserving AI. However, the current research efforts to tackle the three challenges are fragmented and have culminated in a variety of solutions with heterogeneous, non-interoperable, or even conflicting capabilities.  The ambitious vision of HarmonicAI is to build a human-machine collaborative multi-objective design framework to foster coherently explainable, fair and privacy-preserving AI for digital health. HarmonicAI draws together proven experts in AI, health care, IoT, data science, privacy, cyber security, software engineering, HCI and industrial design with an underlying common aim to develop concrete technical and operational guidelines for AI practitioners to design human-centered, domain-specific, requirement-oriented trustworthy AI solutions, accelerating the scalable deployment of AI-powered digital health services and offering assurance to the public that AI in digital health is being developed and used in an ethica