RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Advanced diesel cycle development for mid size engines with high pressure piezo common rail (D-CYCLE)'.

assistant: **Innovation**

Diesel engines equipped with common rail are getting more and more important in todays passenger cars. These engines are marking now the top of modern engine development. The future of Diesel engines is depending very strongly on the capability to reach the future emission levels. One of the best chances to reach such targets is to modify the combustion system. Scientist all in the world is now investigating the basics of the homogenous combustion. Well-known problems are the limited range in the engine map for the use of the homogenous combustion. The target of this project is to develop a combustion system for the use in a passenger car. In a wide range of the engine map the homogenous combustion should be the first choice, but for the driveability of a car it is also necessary to realize a combustion system to achieve rated power. These hard facts leads to the development of a new fuel metering strategy combined with a new combustion system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Building and Promoting a Linux-based Operating System to Support Virtual Organizations for Next Generation Grids' (XtreemOS) targeting Sixth Framework.

assistant: **Abstract**

The overall objective of the XtreemOS project is the design, implementation, evaluation and distribution of an open source Grid operating system (named XtreemOS) with a native support for virtual organizations (VO)and capable of running on awiderange ofunderlying platforms,from clusters to mobiles. The approach we propose in this project is to investigate the construction of a new Grid OS, XtreemOS, based on the existing general purpose OS Linux. A set of system services, extended those found in the traditional Linux, will provide users with all the Grid capabilities associated with current Grid middleware, but fully integrated into the OS. The underlying Linux will be extended as needed to support VOs spanning across many machines and to provide appropriate interfaces to the Grid OS services. Installed on each participating machine, the XtreemOS system will provide for the Grid what an operating system offers for a single computer: abstraction from the hardware and secure resource sharing between different users. It would thus considerably ease the work of users belonging to VOs by giving them (as far as possible) the illusion of using a traditional computer, and releasing them from dealing with the complex resource management issues of a Grid environment. By integrating Grid capabilities into the kernel, XtreemOS will also provide a more robust, secure and easier to manage infrastructure for system administrators.<br/>The XtreemOS consortium composition is balanced between academic and industrial partners interested in designing and implementing the XtreemOS components (Linux extensions to support VOs and Grid OS services), packaging and distributing the XtreemOS system, and experimenting with Grid applications using the XtreemOS system. Different end-users are involv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Predictive Understanding of the effects of Global Change on Ecological Communities and Ecosystem Functions' (BEFPREDICT) targeting Horizon Europe.

assistant: **Abstract**

The observed degradation in essential ecosystem services has catalysed a demand for biodiversity promoting policies. To implement them we need quantitative information on how ecosystem functions are changing due to the direct effects of global change vs. effects mediated by changes in biodiversity. With BEFPREDICT, I will tackle this challenge by providing a novel framework for linking global change, through its effects on biodiversity, to ecosystem functions. My approach builds on three recent developments, each transformative in itself but so far essentially unlinked to each other. First, community ecology has significantly progressed our ability to predict how abiotic drivers shape biodiversity. Second, trait-based ecology offers a tool for learning mechanisms behind ecosystem functions. Third, methods developed by climate scientists and statisticians provide tools for predictive model comparison and assessment in ecology, which have so far largely been lacking. Building on these advances, I will: (Objective 1) develop novel predictive models of the joint distribution of species and ecosystem functions that build on community and trait-based ecology (JEF models); (Objective 2) develop a novel toolbox of model comparison and assessment methods for comparing and testing for the predictive limits of ecological models; (Objective 3) apply the JEF models to unique long-term observational datasets. Through this joint approach, I will tease apart the relative roles of direct effect of the abiotic environment on ecosystem functions and the effects mediated by changes in biodiversity. This proposal balances high risk and high gain by aiming at the truly ambitious goal of establish the scope and limits for quantitative predictions of ecosystem functioning. These conceptual and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of a potent dual GCS/GBA2 inhibitor as a best in class Gaucher therapeutic', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Gaucher disease (GD) is an autosomal recessive disorder caused by deficient activity of acid glucosylceramidase (GBA1). Most patients feature a non-neuronopathic (type 1) course of disease and are treated by either enzyme replacement therapy (ERT – administration of recombinant GBA1) or substrate reduction therapy (SRT – treatment with the iminosugar, Zavesca or the ceramide mimic, Eliglustat – inhibitors of glucosylceramide synthase (GCS)). These therapeutic agents do not prevent neurological symptoms in patients suffering from neuronopathic Gaucher forms (types 2/3) and there is thus an unmet medical need for these patients. Potent GCS inhibitors reduce glucosylceramide (GlcCer), the substrate of GBA and the storage material in Gaucher, and also higher glycosphingolipids including gangliosides and globosides, the causative storage materials in Tay-Sachs disease, GM1 gangliosidosis and Fabry disease. We have found a highly attractive lead, BiPheDNM 7 (Figure C below), which we plan to further develop towards a phase I/II clinical candidate. This proof of concept project will result in a packet comprising this lead molecule, accompanied by all the relevant data and tools to start phase I/II clinical development together with a pharmaceutical partner.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Macrophage Proteoglycans in Atherosclerosis' (ATHEROGAG).

assistant: **Concept**

Cardiovascular diseases (CVD) are the leading cause of death in Western societies. CVD-related deaths are primarily caused by complications of atherosclerosis, a disease initiated via focal infiltration and retention of lipoproteins in the subendothelial matrix of arteries due to a combination of aggregation and interaction with proteoglycans produced by the arteries. Little is known about the in vivo contribution of macrophage-derived and -associated proteoglycans during atherosclerosis development and progression. Considering this dearth of knowledge we will address two objectives: First, we want to determine the in vivo impact of reduced sulfation of macrophage proteoglycans on atherosclerosis using conditional mouse models lacking macrophage-specific Ndst1 functionality on an LDLR-deficient background.  Atherosclerotic lesion quantity and quality will be analyzed in conjunction with macrophage lesion infiltration and lesion apoptosis and efferocytosis. Secondly, we want to evaluate the importance of proteoglycans for macrophage foam cell conversion, another key event in atherogenesis. Using macrophage cell cultures from wild-type or mutant mice we want to determine the importance of biosynthetic genes involved and the array of proteoglycans expressed before and after conversion. In addition the cells will be used to identify a specific proteoglycan important for conversion which will be consequently evaluated for its impact on atherosclerosis in vivo. During his mobility, the applicant will receive didactic (glycobiology, management, intellectual property, grants) and hands-on (MS, macrophage cultures, qPCR, shRNA, flow assay) training as well as network opportunities which will be implemented in the European return institution. Altogether, the generated data should
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'From Babylon to Baghdad: Toward a History of the  Herbal  in the Near East' (FLORIENTAL), addressing dissemination and exploitation.

assistant: **Impact**

Recent publications such as Sylvain Gouguenheim s Aristote au Mont Saint Michel (2008) have called into question the role played by Near Eastern (and especially Arab and Muslim) scholars in the transmission of Greek philosophical, scientific and medical knowledge from antiquity to the middle ages. At the very heart of this problem is the  translation movement  sponsored by the ¿Abb sid caliphs and wealthy Muslim intellectuals of 8th-10th century Baghdad, and especially its most celebrated protagonist, $unayn ibn Is% q, whose translations from Greek into Syriac and Arabic proved to be foundational. On a superficial level, the questions raised have attracted much media attention, with some critics even evoking the notion of a  cultural clash  (between the Christian West and the Islamic East). An informed and sober evaluation of this issue is not yet possible, however, since many of the Syriac primary sources shedding light on $unayn s translational activity remain unpublished and therefore inaccessible to historians. The  Floriental  project will publish the pertinent sources for one particular text genre among $unayn s scientific writings, that of the  herbal  (defined as a list of plants accompanied by descriptions of their therapeutic properties). Still, $unayn and his school did not work in a vacuum (as he himself admits in his famous Ris la), thus the necessity of a second goal: to contextualize $unayn s herbal writings through the study and publication of other Ancient Near Eastern herbals, not only in Syriac but also in the other languages of ancient scholarship (Babylonian, Greek, Arabic, etc.), and especially those which preceded, and in many respects made possible, $unayn s remarkable translational achievements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Quantum Optomechanics with a levitating nanoparticle' to be submitted under Horizon 2020.

assistant: **Abstract**

Micro- and nano-mechanical oscillators with high quality (Q)-factors have gained much interest for their capability to sense very small forces. Recently, this interest has exponentially grown owing to their potential to push the current limits of experimental quantum physics and contribute to our further understanding of quantum effects with large objects. Despite recent advances in the design and fabrication of mechanical resonators, their Q-factor has so far been limited by coupling to the environment through physical contact to a support. This limitation is foreseen to become a bottleneck in the field which might hinder reaching the performances required for some of the envisioned applications. A very attractive alternative to conventional mechanical resonators is based on optically levitated nano-objects in vacuum. In particular, a nanoparticle trapped in the focus of a laser beam in vacuum is mechanically disconnected from its environment and hence does not suffer from clamping losses. First experiments on this configuration have confirmed the unique capability of this approach and demonstrated the largest mechanical Q-factor ever observed at room temperature. The QnanoMECA project aims at capitalizing on the unique capability of optically levitating nanoparticles to advance the field of optomechanics well beyond the current state-of-the-art. The project is first aimed at bringing us closer to ground-state cooling at room temperature. We will also explore new paradigms of optomechanics based on the latest advances of nano-optics. The unique optomechanical properties of the developed systems based on levitated nanoparticles will be used to explore new physical regimes whose experimental observation has been so far hindered by current experimental limitations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Gaussian entropic inequalities and uncertainty relations for communication and secure quantum key distribution'.

assistant: **Concept**

Information and communication technologies are essential to modern society as the internet is pervading all aspects of our lives. Quantum mechanics imposes a fundamental limit to the communication rates. Determining this limit is one of the two challenges addressed by GENIUS. Given the amount of sensitive information sent through the internet, secure communications are essential to our society. To fulfill this need, the EU is investing in quantum key distribution (QKD) with the 1G€ Quantum Technology Flagship. The other challenge addressed by GENIUS is determining the maximum rate for secure communication that can be achieved by the forthcoming generation of QKD devices and proving their perfect security.To address the above challenges, I will firstly apply methods from functional analysis to prove new fundamental entropic inequalities for quantum Gaussian channels. Quantum Gaussian channels provide a mathematical model for the propagation of electromagnetic signals. Entropy is the core of information theory and quantifies the information content of a system. These inequalities will determine the maximum rates allowed by quantum mechanics for communication and QKD. Secondly, I aim to propose and prove a new fundamental entropic uncertainty relation for the heterodyne measurement. This uncertainty relation will prove the perfect security of the most promising QKD protocol. These new insights will have an enormous impact on both quantum communication and quantum cryptography and will stimulate what will be the first realization of quantum devices capable of communication and guaranteed perfectly secure QKD at the maximum possible rates. The experience of my supervisor Prof. Solovej in functional analysis and entropic inequalities combined with the experience of my co-supe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Arqueologia militar Romana en Europa' under Fifth Framework.

assistant: **Concept**

Objetivos de CursoFormación de Jóvenes ivestigadores mediante el desarollo de los objetivos y programas abajo descritos, basados en criterios de proximidad e interactividad, buscando una mejora de los conocimientos teórico-practicos y el contacto con colegas de distintas procedencias.El objetivo fundamental de la propuesta de esta Eschool es preparar a los jóvenes investigadores para una sociedad más compleja, creando medios de comunicación y vias de intercambio y colaboración que generen una dinámica de redes de cooperación con voluntad de continuidad.La Dinámica de Ponentes, muy altamente cualificados, de diferentes procedencias y que actúen en la lectura de sus charlas magistrales o en los talleres implica un alto coste económico pero creemos que puede ser altamente enriquecedor, tanto para su formación como para su enriquecimiento cultural y formativo.La comunicación de ideas y mensajes debe realizarse de una manera clara entre ponentes y alumnos, por lo que se plantea una convivencia intensa a lo largo del curso para lograr estos objetivos.Por último, de estas discusiones deben surgir unos documentos y unas pautas que puedan ser útiles, innovadoras y que tengan aplicación mediata.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New Approaches for the recognition of membrane Bilayers - Therapeutic applications' under Sixth Framework.

assistant: **Concept**

The rapid emergence of bacterial infections resistant to antibiotic drugs has motivated interest in the development of new methods of treatment. In natural systems, antibiotic peptides are part of the first line immunological defence against bacterial infection. These peptides, often having an amphipathic helical structure are believed to exert their effect by the selective disruption of bacterial cell membranes. As this mode of action is not conducive to the development of resistance, they have generated great interest as potential therapeutics. While peptides often have properties such as immunogenicity and instability in vivo that do not favour their development as drugs, it should be possible to design structural analogues with more desirable properties, while maintaining similar or higher activity than the natural peptide antibiotics.The team of Ivan Huc at the European Institute of Chemistry and Biology (IECB) has prepared aromatic oligoamides that fold to form very stable helices in solution. These molecules are versatile scaffolds that are easily prepared synthetically and are expected to be very stable to chemical and biological conditions. Therefore, the goal of this project is to design and synthesize membrane-active antibacterial analogues of these molecules and to study their interactions with membranes using a variety of chemical and biological techniques including NMR, molecular imaging, molecular modelling, phospholipid vesicle models, and bacterial cell culture.These studies will be carried out through collaborations between the Huc group and other teams at the IECB. The results of the project are expected to increase our fundamental understanding of the interaction of amphipathic helices with membranes and to aid in the development of a new class of an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Topographically-driven meteoric groundwater – An important geomorphic agent'.

assistant: **Objectives**

Topographically-driven meteoric (TDM) recharge is a key driver of offshore groundwater systems because sea level has been lower than at present for 80% of the last 2.6 million years. Groundwater has been implicated as an important agent in the geomorphic evolution of passive continental margins and the canyons that incise them. However, the geomorphic efficacy of groundwater remains dubious, and a diagnostic link between landscape form and groundwater processes remains poorly quantified, especially for bedrock and cohesive sediments. Obstacles that prevent going beyond the current state-of-knowledge include: (i) a focus on terrestrial contexts and a lack of mechanistic understanding of groundwater erosion/weathering; (ii) limited information on offshore groundwater architecture, history and dynamics. By addressing the role of TDM offshore groundwater in the geomorphic evolution of the most prevalent types of continental margins, MARCAN is expected to open new scientific horizons in continental margin research and bring about a step-change in our understanding of some of the most widespread and significant landforms on Earth. The project’s methodology is rooted in an innovative, multi-scale and multidisciplinary approach that incorporates: (i) the most detailed 3D characterisation of TDM offshore groundwater systems and their evolution during an integral glacial cycle, based on state-of-the-art marine data and hydrogeologic models, and (ii) the development of a comprehensive continental margin geomorphic evolution model, based on realistic laboratory simulations, accurate field measurements and advanced numerical solutions. By placing better constraints on past fluid migration histories, MARCAN will also have strong applied relevance, primarily by improving assessment an