RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Money, Liquidity, and the Aggregate Economy'.

assistant: **Innovation**

In the last few years, Professor Nobuhiro Kiyotaki (Princeton) and I have attempted to provide the bare bones of a simple, unified theory of money and liquidity that can be integrated into the rest of macroeconomic theory, staying as close as possible to the standard competitive macroeconomic framework. But there is a lot of work ahead. The bones have little or no flesh. Here are some of the major puzzles that are outstanding. Why is it that small adjustments to nominal interest rates by a central bank appear to have such significant effects on the real economy? Why can there be financial instability, even during periods of monetary stability? What are the deep sources of a financial crisis? Has it to do with contractual incompleteness, such as lack of indexation in debt contracts? What externalities may be at work? Is there scope for intervention, to encourage new forms of financial contract, such as  dequity    which offer lenders the same control rights as debt but afford the same degree of risk sharing as equity? Through what mechanism do financial crises spread, both across markets and across countries? Does contagion occur through price effects alone (e.g. falls in the values of collateral), or is the primary channel of propagation through chains of debt and default? How and when might monetary policy ameliorate financial crises? And how does this role for a central bank connect to its role of lender of last resort? As new financial instruments emerge that substitute for fiat money, what is the future of central banking? More generally, how should monetary economics tie in with the economics of payment and settlement? Inevitably, it is difficult to prescribe where our research will take us. Not all of these questions will prove amenable to being answered. It may b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Computational intelligence methods in time-series analysis and forecasting with application to energy management systems' (COMMIT-NRG), addressing dissemination and exploitation.

assistant: **Impact**

The work programme herein proposed is composed of work packages from two research projects where the host institution is starting participation by the end of 2008. The projects consist of: (i) in a partnership with the Portuguese Power Grid Company (PPGC), obtaining electricity demand predictive models at a national scale, through the efficient use of computational intelligence methods. The resulting models will be employed in the PPGC dispatch centre to schedule the operation of electricity production plants; (ii) in a collaboration with the University of Algarve, develop model-based predictive control systems able to maximise people's thermal comfort in buildings, while simultaneously minimise the energy spent in achieving it. The goal is contributing with methods able to decrease energy consumption by climate conditioning devices in buildings, a measure which is estimated to potentially save 8% of the total energy consumption in the European Union.Regarding the first project, the role of the applicant is to supervise and actively participate in the research activities along with the team from the PPGC. In the second project he will participate in the majority of tasks with emphasis on those related to data acquisition, development of predictive models, and the development of the predictive control algorithm.A substantial part of the work in both projects will be devoted to the tasks of building long-term predictive models from acquired data (weather, indoors environment, and electricity demand data). As a consequence, this constitutes an excellent opportunity to contribute in advancing the state of the art of applying computational intelligence techniques in the determination of dynamical non-linear predictive models from acquired data in the form of time series, but
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Novelty tuning: behavioural, electrophysiological and molecular mechanisms of novelty detection'.

assistant: **Innovation**

This proposal addresses one of the most profound determinants of brain function and cognition: how is the brain affected by a stimulus that is novel and is therefore potentially significant? The proposal, centred around the auditory system, will decipher the pathways that start with the detection of a novel stimulus and lead through a cascade of inter-related signals to the induction of the synaptic plasticity. We hypothesize that a novel sensory stimulus is detected by the conjunction of the sensory activity it evokes in cortex with inputs from the neurotransmission systems.This conjunction activates electrophysiological novelty responses and the associated expression of immediate-early genes (IEGs). The IEGs can be used to identify network components within auditory and motor cortices that sub-serve sound frequency discrimination in the behavioural training cortex. They orchestrate changes in the profiles of gene expression, alternative splicing and microRNAs leading to synaptic modifications that ultimately change the animal behaviour. To test this model we will study novelty detection using three different readouts: behavioural, electrophysiological and molecular. Genetic engineering manipulations and molecular techniques will be used to assess the relationships between these readouts. Brain disorders such as schizophrenia are associated with abnormal sensory gating of novel vs non-novel stimuli. The expression of such pathologies requires interactions between environmental, electrophysiological and molecular mechanisms.The NovelTune teams aim to link these various processes and elucidate the underlying mechanisms through an interdisciplinary strategy. The network integrates strong expertises including state-of-the-art and high throughput gene expression technologie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'On the trails of new neutrino properties' in the context of a Seventh Framework call.

assistant: **Objectives**

Neutrino masses and mixing are the most tangible evidence for the shortcomings of the Standard Model and finding a more complete theory remains the most challenging task for elementary particle physics. Neutrinos can lead us on the trail to new physics, together with experiments at the LHC, flavor physics and cosmology. The best time for carrying out this project is now. Neutrino physics is more vibrant than ever as a renewed flow of key data has just begun. First evidence that the hitherto unknown value of the third neutrino mixing angle theta(13) is sizeable raises concrete hopes of observing CP-violation in the lepton sector, triggering new ideas for model building. Moreover, the entire neutrino community is intrigued by several experimental anomalies that hint at unexpected neutrino properties. This animated scenery provides an ideal stage for the ""NuTrails"" project, having neutrinos as its main actors. Following the trails of these elusive particles to the smallest scales will serve as a formidable guide to new discoveries.More specifically, this project will focus on two different classes of standard-model extensions. First, signs for new physics originating from heavy mediators at the TeV scale will be studied. Second, manifestations of a new low-energy scale will be sought, hunting for light ""sterile"" neutrinos with mass in the eV range.  Theoretical questions related to neutrino flavor conversion in the presence of such new properties will be addressed.  Furthermore, observable consequences for present and future experiments will be quantified. These results will have far-reaching implications, extending from particle phenomenology to astrophysics and cosmology. Most importantly, the quantitative simulations will decisively influence the next round of exper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of an Easy-to-use Metagenomics Platform for Agricultural Science' (MetaPlat).

assistant: **Concept**

The aim of this project is to bring together experts from the academic and non-academic sectors and to create an easy-to-use integrated hardware and software platform. This will enable the rapid analysis of large metagenomic datasets. It will provide actionable insights into probiotic supplement usage, methane production and feed conversion efficiency in cattle. In the recent years, the number of projects or studies producing very large quantities of sequencing data – analysing microbial communities make-up and their interactions with the environment – has increased. Yet, the depth of analysis done is very superficial and represents an inefficient use of available information and financial resources.  This project aims to address these deficiencies and  will study the change within microbial communities, under various conditions in  cattle guts and impacting probiotic supplement usage, methane production and feed conversion efficiency in cattle. To succeed, we propose to develop faster and more accurate analytic platforms in order to fully utilise the datasets generated. By focusing on better hardware and software platforms, better expertise and training, this project will pave the way for a more optimal usage of metagenomic datasets, thus reducing the number of animals necessary.  This will ensure better and more economic animal welfare.The Meta-Plat project objective is a mixture of innovative research, focused application and commercial awareness. The core objectives being pursued are:•Sample gut collection, from cattle, for sequencing;•Collection of publically available databases – to create a new classification of previously unclassified sequences, using machine learning algorithms;•Development of accurate classification algorithms;•Real-time or time-efficient comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'iSocial: Decentralized Online Social Networks' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The rapid proliferation of Online Social Networking (OSN) sites, like Facebook and MySpace, is expected to reshape the Internet’s structure, design, and utility. Industry experts believe that OSNs create a potentially transformational change in consumer behavior and will bring a far-reaching impact on traditional industries of content, media, and communications. Nevertheless, at a European level, there is a recognized shortage of highly skilled researchers, scientists and engineers trained in building IT platforms and service infrastructures capable of hosting innovative OSN services and applications. The iSocial consortium, which consists of 7 full partners and 6 associate partners, envisions the emergence of distributed and scalable overlay networking and distributed storage infrastructures that will provide support for open social networks and for innovative social network applications, preserving end-user privacy and information ownership. The main objective of iSocial is to provide world class training for a next generation of researchers, computer scientists, and Web engineers, emphasizing on a strong combination of advanced understanding in both theoretical and experimental approaches, methodologies and tools that are required to develop Decentralized Online Social Networking platforms. iSocial training network will fund 11 Ph.D. students; 5 post-doctoral fellows for 18 month stays, 2 intensive post-graduate schools, 3 workshops and a final Conference. To meet this goal, iSocial is divided into four interconnected research topics: i)Overlay Infrastructure for Decentralized Online Social Networking Services; ii)Data storage & distribution; iii)Security, privacy & trust,iv) Modelling and Simulation. These topics include important and timely research challenges with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Support to Sixth European Conference on Turbomachinery - Fluid Dynamics and Thermodynamics, Lille, March 2005'.

assistant: **Innovation**

Following the successful first five conferences on Turbomachinery in Erlangen (Germany), 1995, in Antwerp (Belgium), 1997, in London (Great Britain), 1999, in Firenze (Italy), 2001 and in Prague (Czech Republic), 2003, the ETC Committee has unanimously de cided to hold the next conference in 2005 in Lille (France) following therewith the invitation of the Association Française de Mécanique and co-operating bodies in France. The Conference will be of primary interest to researchers, design engineers and use rs of Turbomachinery components. The Conference is intended to be a primary event for technology transfer across Europe in this field through the presentation of latest developments and best practice. The conference is also seen as an integrating element between the Western and Eastern European countries and as an additional mean to foster collaboration in turbomachinery research at a European level. Finally this conference is seen as an ideal forum to relate the results of research projects funded by the European Commission and benefits therefore also from the support by the Commission.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Piezoelectronic Transduction Memory Device' (PETMEM) under Horizon 2020.

assistant: **Objectives**

Computer clock speeds have not increased since 2003, creating a challenge to invent a successor to CMOS technology able to resume performance improvement. The key requirements for a viable alternative are scalability to nanoscale dimensions – following Moore’s Law – and simultaneous reduction of line voltage in order to limit switching power. Achieving these two aims for both transistors and memory allows clock speed to again increase with dimensional scaling, a result that would have great impact across the IT industry.We propose to demonstrate an entirely new low-voltage, memory element that makes use of internal transduction in which a voltage state external to the device is converted to an internal acoustic signal that drives an insulator-metal transition. Modelling based on the properties of known materials at device dimensions on the 15 nm scale predicts that this mechanism enables device operation at voltages an order of magnitude lower than CMOS technology while achieving 10GHz operating speed; power is thus reduced two orders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of methods for genome-wide association studies', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Genome-wide association studies have been very successful - and yet much of the genetic contribution to complex diseases remains unexplained. In-depth mining of GWA data sets may provide evidence of further novel variants: this could be through looking at epistasis, gene-environment interaction, disease sub-phenotypes, rare variants. These analyses can be applied to a range of data sets available to us including type 2 diabetes, Crohn's disease and anthropological traits including BMI, height and adiposity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Revealing the Epigenetic Regulatory Network with Single-Molecule Precision' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Genes and genomic elements are packaged by chromatin structures that regulate their activity. The fundamental unit of chromatin is the nucleosome, composed of an octamer of histones. The large numbers of histone modifications, chromatin remodelers and transcription factors (TFs) that interact with our genome has fuelled speculation that multiple elements act combinatorially to direct specific outcomes. However, the field lacks technologies for detection and analysis of such combinations, thus impeding our ability to test this hypothesis and shed light on human genome regulation. Our recent proof-of-principle for a single-molecule system for mapping combinatorial chromatin modifications holds the technological solution. This powerful method can identify directly unique combinations of epigenetic marks and reveal regulatory modules that can only be ascertained by single-molecule studies.The proposed project will scale-up and advance our technology to establish robust high-throughput systems for investigating combinatorial chromatin and TF interactions and identify their genomic locations, thus bridging the gap between single-molecule proteomics and genomics. We will apply it to address basic questions in epigenetic regulation during early development, and define the network of interactions between histone marks, DNA methylation and the core TFs in stem cells and differentiated cells. We will also harness our technology to reveal the tissue-of-origin of cell-free DNA circulating in our blood in the form of nucleosomes, and apply it to devise novel strategies for early detection of cancer and other diseases.Successful implementation and dissemination of these novel systems will yield a transformative new technology for functional genomics that will unravel the chromatin lan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Switching the structure-function relationship of proteins by mechanical forces: physiological and technological implications'.

assistant: **Innovation**

After a decade of new insights into single molecule mechanics, my key interests are now directed towards asking how (a) mechanical forces can alter the structure-function relationship of proteins and (b) whether such force-regulated structural alterations are of physiological significance. Since forces are applied by cells via the transmembrane integrin junctions to the extracellular matrix, my goal is to decipher how the extracellular matrix protein fibronectin, integrins, and cytoplasmic scaffolding proteins that link integrins to the cytoskeleton are functionally regulated by force.  Using high performance computational approaches, we will derive with Angstrom precision how their structures are changed when stretched using Molecular (MD) and Steered Molecular Dynamics (SMD). Knowledge how tensile forces alter the structure of proteins is central to develop experimentally testable mechanisms how force might regulate various functions.  Experimentally, we will first address how the many different functions of fibronectin are regulated by force.  This will involve quantitative studies how the interaction of fibronectin fibers with various serum proteins and growth factors is altered when mechanically strained. Preliminary studies show already that the strain-dependent binding can vary greatly among different serum proteins. We will then investigate whether the stretching and unfolding of extracellular matrix proteins co-regulates cell phenotypes.  Finally, understanding the principles of mechanotransduction is not only crucial to gain far deeper insight into how cells work, but new technologies might be derived from these novel insights.  Our longer-range goals are thus to develop new technologies that exploit proteins as mechanically regulated switches, from the design