RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Investigations on degradation mechanisms and Definition of protocols for PEM Fuel cells Accelerated Stress Testing' (ID-FAST).

assistant: **Innovation**

ID-FAST aims at supporting and promoting the deployment of Proton Exchange Membrane Fuel Cell (PEMFC) technologies for automotive applications through the development of Accelerated Stress Tests (AST) together with a methodology allowing durability prediction, thus accelerating the introduction of innovative materials in next generation designs.The project is founded and focused on two main points: degradation mechanisms understanding and durability prediction improvement via the development and validation of specific ASTs and associated transfer functions. Degradation investigations will be based on consolidated data (objects with known history and ageing data) from both real systems tested in cars and ID-FAST test program to ensure relevant analysis of failure modes and performance losses together with a mean to validate the developed methodology. Investigation of stressors impact on components degradation and performance losses will give access to the accelerating factor for each single mechanism AST.Thanks to the expertise of partners, understanding will be ensured by advanced ex-situ and in-situ characterisations to identify and quantify components degradation phenomena, and by modelling and multi-scale simulation tools to investigate the impact of various stressors and to relate causes to  performance losses.Combined AST protocols will be developed and validated with regard to their capability to actually reduce testing time and their relevance assessed by correlation to real world ageing. The methodology developed will allow prediction of stack lifetime and thus will be valuable for the whole automotive fuel cell community.To achieve its objectives, ID-FAST will benefit from the strong expertise of 8 partners (4 research centres, 1 university, 1 SME and 2 large c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Socio-economic change, individual reactions and the appeal of the extreme right' (SIREN).

assistant: **Concept**

The project aims to analyse subjective perceptions of, and individual reactions to socio-economic change focusing on employment and working conditions in Europe. The aim is to create original knowledge for the debate on flexibility and security in the European social model, and provide an empirical assessment of the extent to which changes in working life can be said to make people receptive to right-wing extremism/populism. The interdisciplinary and comparative investigation will cover eight countries; it will encompass literature reviews, secondary data analysis, primary qualitative and quantitative data collection, and workshops with social partners, NGOs and policy makers. On the basis of new insights in the subjective perceptions of and individual reactions to socio-economic change, policy recommendations will be developed for fine-tuning employment and social policies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Spatio-temporal control of the Src kinase activation through Optogenetics in Cell invasion' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Cell signaling is a complex system that coordinates cell actions in response to environmental inputs. Signaling pathways are often seen and investigated as on/off networks, but the reality of the intensities and spatio-temporal organization of these networks has been poorly integrated with the dynamics of cellular outputs in response to specific environmental inputs. In the OSS project we aim to approach this general problem by focusing on a specific cellular function, cell invasion (the hosts area of expertise). We propose to 1) use the formation of invadosomes, characteristic acto-adhesive structures important for cell invasion as a specific cellular function, to address these fundamental questions 2) and target the pleiotropic tyrosine kinase Src that has the ability to induce cell invasion globally by acting on cell adhesion, migration, contractility and invadosome dynamics independently of any environmental regulation, to investigate how a biological signal can be dynamically encoded into specific multifarious cellular outputs. Our hypothesis is that specific spatio-temporal patterns of Src activation could be the basis of its pleiotropicity. Thus, the first step of the OSS project will be to use Src biosensors to observe different patterns of Src activation and correlate them with the dynamics of Src-dependent cellular outputs (such as induction of invadosomes). Secondly, we will directly control spatio-temporal Src activity in live cells using optogenetics, a powerful and innovative approach that will allow us to mimic the observed patterns of Src activation and to create new patterns in order to explore dynamic equilibrium between Src signaling and its specific cellular outputs. This project is at the cross-road of signaling theory in biology, cell biology of ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Negotiating Digital Technologies in Palliative Home Care' in the context of a Horizon Europe call.

assistant: **Objectives**

Most Europeans wish to spend their final hours at home, surrounded by loved ones. Specialist palliative home care services have been established to fulfill this wish, even for patients facing severe terminal illnesses. The sociological research project NEDIPAL: Negotiating Digital Technologies in Palliative Home Care aims to better understand the intricacies and challenges of using digital technologies  such as teleconsultations, apps, wearables, and artificial intelligence  to make palliative home care more accessible to a broader range of patient groups, while also enhancing its economic and environmental sustainability.Current research typically views digital technology usage in palliative home care either from the viewpoint of patients and family caregivers or of professionals, with both seeming decoupled from one another. In contrast, NEDIPAL examines the co-production of palliative home care by professionals in collaboration with patients and family caregivers, through the lens of systems and organizational theory. The sociological project transcends disciplinary boundaries by integrating insights from health services research, palliative medicine, communication, and digital inclusion.The research will involve qualitative on-site field studies in the Belgian region of Wallonia at five interdisciplinary quipes de soutien  domicile. NEDIPAL is hosted by BRISPO, an interdisciplinary research center specializing in digitalization, health, life course, and aging.With my supervisors international experience and unique competence, along with my prior research in palliative home care and experience in France, I am confident that I will achieve NEDIPALs research and training objectives and position myself as a leader in research on the digitalization of palliative care. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Effects of systemic annonacin exposure in transgenic mice expressing normal or mutant human tau protein: role of environment-gene interactions in neurodegeneration' to be submitted under Sixth Framework.

assistant: **Abstract**

Experimental and epidemiological studies have identified natural substances, such as the acetogenin annonacin, that could be associated with mechanisms of neurodegeneration in some forms of tauopathies. Many mutations in the tau gene have also been associa ted with familial cases of tauopathies, such as the frontotemporal dementias with parkinsonism linked to chromosome 17 (FTDP-17). However, it is still not clear what is the relative contribution of genetic and environmental factors to the observed neurodeg enerative changes (neuronal loss and pathological tau aggregation) and how specific genetic backgrounds affect the susceptibility towards the exposure to environmental toxins. The goal of this proposal is to investigate gene-environment interactions using experimental models of Tau-associated neurodegeneration. We propose to determine whether there is a pathogenetic synergy between annonacin intoxication and mutations in the tau gene that lead to FTDP-17. Our proposal will take advantage of the transgenic mouse technology to study the effects of a natural toxin on animal models bearing specific genetic background. The results obtained may also increase our understanding of physiopathogenic mechanisms of major neurodegenerative diseases where a gene-environm ent interaction appears to play a role as is the case of Parkinson's and Alzheimer¿s diseases. The proposed research project has emerged from a consortium of three groups in Europe (Germany, France, Guadeloupe) in cooperation with an experienced researcher from a developing country (Brazil). The realization of the proposed work will strongly strengthen the infrastructure of cooperation between the European partners and will contribute to the human capacity building in the area of neurodegeneration in Brazil .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Organizing, Promoting and ENabling HEritage Re-use through Inclusion, Technology, Access, Governance and Empowerment'.

assistant: **Objectives**

OpenHeritage aims at developing and testing an inclusive governance model and a supporting toolbox for the adaptive re-use of cultural heritage assets. It builds on the role of communities and the possibility of empowering them in the redevelopment process based on the concepts of heritage community and participatory culture. The project operates with an open definition of heritage, not limited to listed assets but also involving those buildings, complexes, and spaces that have a symbolic or practical significance for local or trans-local heritage communities. Inclusiveness also means the incorporation of a coalition of stakeholders into the re-use and maintenance process, the integration of resources involving new financial and economic models, and working with the local social, environmental, administrative, and economic context of the heritage sites. Territorial integration is an essential element as well: the planning process goes beyond a building or a site to contribute to the transformation of wider areas.OpenHeritage connects diverse cases across Europe, involving sixteen Observatory Cases (OCs), which are adaptive re-use projects that are studied and compared in-depth, and six Cooperative Heritage Labs (CHLs), on-going projects overseen by consortium partners, where it co-creates and tests its inclusive model. The cases are situated in a variety of urban, peri-urban, and natural environments, and include diverse heritage assets.OpenHeritage will launch a website (Heritage Point) to provide a forum for engagement and support resource integration at the CHLs, and will create a database of macro- and micro-level research results, connecting systematically collected information on the regulatory framework all over Europe with current heritage re-use practices as an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Innovative processing plant for optimal production of Decolourised Hydrolysed Protein (DHP). A secure, cost-effective and eco-friendly blood by-product solution.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Our overall objective is to bring to the market a new solution which will not only reduce the environmental impact of blood produced in slaughterhouses, but optimize the protein production process for animal and human feed purposes too, in a reliable and cost-effective way. According to the FAOSTAT (2016) website, approximately 1452 million pigs were processed worldwide for their meat in 2013. From these, 309 million pigs were processed only in Europe (mainly in Spain, France, and Germany). If we consider that 3 litres of blood can be collected from each pig, the annual available blood supply can exceed 927k tonnes of blood in Europe and 4.35 million tonnes worldwide. With current technologies available into the market, only around 7% of the protein content in blood can be recovered. From AZUARA we have identified the business opportunity behind this market weakness, and we have developed the HYDROBLOOD processing plant to solve it. With our innovative processing plant, the whole content of protein can be recovered from animal’s blood. Moreover, HYDROBLOOD will reduce significantly the environmental impact, since it does not need refrigeration nor heating installations, it generates almost no zoo-technical blood, and it reuses the total waste water generated. It will make a revolution within the meat sector, since the slaughterhouses will not only avoid the treatment of a high polluting waste (and its associated costs) but convert it into a high added value product that will suppose an increase by around 5% in their annual turnover.HYDROBLOOD processing plant produces 200g per litre of blood of Decolourised Hydrolysed Protein (DHP), a high quality blood by-product with 95.85% of protein content and a high digestibility (99.54%), which will make a difference in the feed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Optics in astrophysics' to be submitted under Fifth Framework.

assistant: **Abstract**

Among the forthcoming most challenging topics in astrophysics are the search for exoplanets and exobiology, the understanding of star and planet formation and the identification of the formation of galaxies in the early Universe. All are highly demanding on the observational tools. To address them, tools and methods of observations must take a major leap.Studies for extremely large telescopes (50 and 100m in diameter) have begun to be carried on in Europe, as well as ground based or space large optical telescope arrays. New technologies must be developed to set up and phase such large optical surfaces. Also, optical components or the way to handle photons will need breakthroughs from ongoing and coming researches and developments in optical fields: e.g. adaptive optics with ~ 1000 times more actuators than for current 8m telescopes are required for diffraction limited imaging at a future 100m telescope.New kinds of instruments are emerging, as chronographs to evidence very faint companions close to bright sources, with stringent requirements to avoid scattered light. Giant spectrographs will be built: how and with which dispersive optics? Detectors are concerned as well; at least 100 times more pixels than required for the European VLT will be necessary. Of course data processing algorithms, in particular image restoration and de-convolution will have to evolve accordingly.The School aims at teaching young researchers of both astrophysical and optical communities who are to play an important role within these long-term fascinating projects. The guideline of the main themes is first to rely on the underlying physics involved in methods or techniques used at or for telescopes. Then the current state of the art in the industry and the major trends of the R&D in the laborat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The international congresses and the transnational shaping of philosophy (1900-1948): Spaces – Struggles – Identity – Knowledge' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

INTERPHIL analyses the construction of philosophy’s disciplinary identity by studying the first ten International Congresses in Philosophy (1900-1948), relating them to the emergence in Europe of a new academic space that aimed at unity across different schools of thought. Today, the still persistent cleavage between the “analytic” and “continental” ways of practicing philosophy, hyper-specialization and hyper-production suggest that the project of a philosophical unity was not achieved. The majority of philosophers currently acknowledge the uncontrollable pluralism of the discipline and have abandoned the dream of a transnational community aiming at collectively defining the discipline and at discussing its main advancements. Still, this dream had important consequences, as it fostered the emergence of institutional spaces of intellectual exchange. At the beginning of the 20th century, for the first time in history, the International Congress in Philosophy, organised, then supervised by a French group over almost fifty years, aimed at achieving this philosophical exchange and unity. The group of philosophers involved got progressively larger, and had to arbitrate disputes between different participants and include or co-opt subalterns or self-excluded European and non-European groups, such as those from Russia. How did these actors deal with the contradiction between ambitions of universalism and rising nationalisms?  INTERPHIL adopts an inter-disciplinary and multi-scalar approach in order to explain the constitution of a transnational philosophical space, the formation of philosophical ideas of Europe and the participation of philosophers in international institutions such as the League of Nations. The approach is socio-historical: bibliometric, lexicographic, sociol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Understanding the physiological and pathological relevance of liquid-liquid phase separation by synuclein family of proteins' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Proteins are among the most essential molecules of life. In recent times, it has been discovered that proteins can undergo liquid-liquid phase separation (LLPS) to form highly efficient droplet reservoirs for its functionality. However, these concentrated protein droplets can also lead to pathological protein aggregation and toxic amyloid fibril formation. One such example is α-synuclein (α-Syn), which can undergo LLPS-mediated amyloid aggregation associated with Parkinson’s disease (PD) pathogenesis. The physiological and pathological relevance of α-Syn LLPS remains elusive in the context of many biological factors such as familial mutations, presence of other synucleins, protein modifications and lipid membrane interaction. All of these factors significantly modulate the aggregation of monomeric α-Syn in solution. In this proposal, I aim to elucidate and quantify the effects of these mentioned in vivo relevant factors on the phase separation of α-Syn in a high throughput (HTP) and quantitative manner. While my work was the first to show that α-Syn can undergo LLPS; the host laboratory has developed a microfluidics based HTP method perfectly suited for protein LLPS related research. During the course of this project I will get trained on this particular technique along with several other sophisticated instruments. The outcome of this project will significantly help to elucidate the molecular origins of PD and provide important insights with respect to the onset time and progression of PD pathology, which is currently poorly understood. The knowledge obtained from this study will have crucial impact on the European society and the results might also be of interest to the pharmaceutical industries to effectively design new drugs against the progression of PD pathology in