RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Chemical Tools for Transcriptome-wide Analysis and Modulation of RNA'.

assistant: **Objectives**

RNA is an essential biomolecular polymer that exhibits many cellular functions ranging from catalytic to informational that are crucial for life. Long considered as DNA's unexciting counterpart, RNA has in recent years transcended its dull image, driven by pivotal discoveries of its involvement in cellular signalling pathways. Despite the clear importance of RNA in biology and medicine, many of its properties and functions remain elusive.In the RiboChem program we will develop ground-breaking chemical tools for uncovering the identity, function, structure and druggability of RNA on an unparalleled transcriptome-wide level, with a special focus on riboswitches. Riboswitches are structured RNA molecules that have gathered particular interest due to their involvement in bacterial gene regulation that render them attractive targets for antibiotic development. The proposed tools will combine refined chemical design and synthesis, tailored towards RNA's chemical properties, with advanced sequencing technologies. This unique combination enables the discovery of riboswitches throughout the entire transcriptome using a photoaffinity labelling strategy. Customized chemical probes will be used to measure riboswitch conformational dynamics in response to environmental inputs and reveal how bacteria exploit these phenomena to fine-tune their gene expression. Finally, a paradigm-shifting strategy for modulation of riboswitch activity will be developed by applying small molecule covalent modulators of RNA structural elements, which has the potential of transforming the field of RNA targeting. Taken together, the research within RiboChem will find broad applicability in the emerging field of RNA chemistry and biology and help uncover many biological functions and properties of RNA and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Guiding glioblastoma treatments by decrypting tumor biomechanics via Magnetic Resonance Elastography.' (GLIOBID).

assistant: **Concept**

Glioblastoma multiforme (GBM) is the most common and deadly type of primary brain tumour, carrying a dire prognosis with a median survival of 14.6 months for patients undergoing standard treatments. The causes of poor clinical prognosis are late diagnosis, diffuse infiltration, pseudo necrosis, high neovascularization and resistance to therapy.  In principle, drugs can reach the tumors via the vascular system, but the tumor microenvironment plays the role of an antagonist to any efficient drug delivery whereby reducing treatment efficacy. Recent treatments combine chemotherapy with drugs which aim at re-normalising the tumor microenvironment by releasing the mechanical pressure and/or by reducing the angiogenesis. However, there are yet no imaging biomarkers clinically available which can disentangle the different effects of the therapy on the components of the TME. This hinders patient management in particular dosage.  GLIOBID project aim at disentangling the therapy impact on tissue integrity and pressure from the modulation of tumour vasculature by quantifying tissue rheology with magnetic resonance Elastography (MRE). This imaging breakthrough will allow to assess the effect of treatments on the main target – the tumor - and the pathways to reach it – the vessels and the tumour microenvironment - providing a unique guidance to tailor combined therapies based on component-specific biomarkers. GLIOBID will involve the main experts in the field of imaging and cancer biology, creating a highly multidisciplinary and eminently clinical environment. This together with the complementary expertise of researcher and hosting institutions will provide the best conditions for decrypting the complexity of the problem and find approaches translatable to the clinical routine. GLIOB
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A comprehensive CAD system based on radiologic- and pathologic-image biomarkers for diagnosis and prognosis of breast cancer relapse' to be submitted under Horizon Europe.

assistant: **Abstract**

Breast cancer (BC) incidence in women produces more than 600,000 deaths each year. The primary cause of death in BC patients is metastasis, whereby cancer cells spread from their primary site of origin and grow in adjacent or distant sites. Distant metastasis produced due to the relapse of the illness is incurable, underscoring the inadequacy of our understanding of its mechanisms. The first step for fighting against disease progression is screening programs for BC focused on image analysis of mammography, MRI and tomosynthesis. Once the tumour has been diagnosed and given the high variability of clinical progressions, another problem arises: classifying the cancer type and determining the proper treatment for specific cancer. Moreover, in BC, the immune response from the tumour microenvironment has played an essential role in tumour evolution. To evaluate the tumour and its microenvironment, one technique garnered a lot of attention in the last years: Whole Slide Imaging (WSI). This technique replaces the use of the microscope for classical diagnosis. Still, it has also been used for developing biomarkers that allow the analysis of tumours and classification of cancer subtypes and the study of the immune tumour microenvironment. The use of WSI has applications for predicting the probability of relapse for distant metastasis. Now, for the first time, BosomShield proposes to join the two disciplines (pathological and radiological imaging) in a software that will analyze these images to classify the cancer subtypes and predict (together with the complete clinical history of the patient) the probability of relapse for distant metastasis. Besides, BosomShield will provide high-level training in BC research to young researchers by offering the necessary transferable skills f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Origins of cell diversity in multicellular tissues' to be submitted under Horizon 2020.

assistant: **Abstract**

Multicellular tissues, and ultimately complex organisms, are composed of multiple distinct cell types that differ in functional attributes. Such diversity in cell composition (i.e. phenotypic diversity) arises during development and regeneration, where progenitor cells differentiate along multiple cell fate lineages to form a heterogeneous population. While the molecular signals (i.e. cell states) that specify individual cell fates are widely studied, less is known about how multiple cell types can simultaneously emerge from a seemingly homogeneous population and which molecular mechanisms coordinate this process on a tissue-wide scale. Increasing evidence suggests that stochastic events, as opposed to hard-wired deterministic processes, are critical for emergence of heterogeneity. However, the molecular mechanisms that drive stochasticity and diversity in a mammalian tissue remain unknown, mainly due to a scarcity of tools to measure stochastic events in large numbers of single cells and to perturb cell-to-cell heterogeneity on a tissue level. Here I propose to use quantitative single-cell imaging,  transcriptomic approaches, and optogenetic control of tissue heterogeneity to identify the molecular mechanisms driving phenotypic diversity. I will apply these techniques to mouse intestinal organoids, a multicellular system that recapitulates the intestinal epithelium. I hypothesize that variability in cell state (at the single-cell level) drives cell phenotypic diversity (at the tissue level). Different combinations of dynamic molecular signals within single cells may thereby pattern populations within a tissue to adopt specific fate outcomes. Gaining insight into the mechanisms of phenotypic diversity will answer fundamental questions in developmental and synthetic biol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Automated autologous cell therapy system'.

assistant: **Objectives**

The global burden of cancer, calculated as the cost of years lost from ill-health, disability or early death, currently outweighs all other health concerns including cardiovascular diseases . Among all cancers, metastatic melanoma (MM) represents one of the major health problems. Unlike other solid tumors, which mainly affect older adults, MM is notorious for affecting young and middle-aged people, results in 66000 related deaths yearly worldwide (World Health Organization) and therefore has a large impact on years of healthy life lost.Recently, promising results of autologous cell therapy (ACT) with tumour infiltrating lymphocytes (TILs) have shown that up to 20% of patients can be cured with one single course of this immunotherapy   . This treatment has been conducted at a handful of institutions with over 1.000 patients treated worldwide. The resulting survival rates of patients treated confirm this approach as being among the most efficient therapies available. Importantly, this novel treatment has the potential to be expanded to the treatment of other cancer types. However, there is a need for dedicated bioreactors for the expansion of TILs for the individual patients. Bioreactors that can provide high cell densities and high absolute cell numbers. Further, TIL production for ACT is labour intensive and must be performed in a sterile cleanroom. This limits the use of this new and efficient cancer treatment to a few highly specialised hospitals. The aim of this application is to develop a dedicated bioreactor that will enable the treatment to be used on an extended number of hospitals. The commercial potential for ACT is estimated to be more than 4 Billion $ per year. .This project is therefore seen as relevant for the topic: Supporting innovative SMEs in the health
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multidimensional Image Coding. Applications to Remote Sensing and Telemedicine' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The research proposal focuses on the coding and transmission of massive images, i.e. those images acquired by sensors able to capture data with more than 3 dimensions. Such multi-dimensional images are currently available in the medical environment, including functional Magnetic Resonance Imaging (fMRI) in 4D (3D spatial + 1D temporal), and also in Remote Sensing scenarios, e.g. through Atmospheric Infrared Sounder Sensor (AIRS), which continuously captures ultra-spectral images of the Earth’s surface producing ultra-spectral video (2D spatial + 1D spectral + 1D temporal). With the ever increasing number of sensors acquiring massive images in airplanes, satellites, and medical centres, there is an urgent need in institutions and centres to properly deal with such data. There are few studies tackling the coding and proper manipulation of such massive data sets. Nevertheless, Prof. Michael W. Marcellin (Dept. of Electrical and Computer Engineering, University of Arizona, USA) and the Group on Interactive Coding of Images (GICI, Dept. of Information and Communications Engineering, Universitat Autònoma Barcelona, Spain) have established themselves as pioneers in this nascent field. The core of the proposed project will be built upon the ISO standard JPEG2000; Prof. Marcellin was one of its key developers, and many applications thereof. We hereby propose to host Prof. Marcellin with GICI during 18 months to create the ideal team for research on the coding and transmission of massive images. The study will be undertaken on digital medical images granted by Parc Tauli Health Corporation (Sabadell, Spain), and on remote sensing images granted by Center for Ecological Research and Forestry Applications (Bellaterra, Spain), ensuring the relevance and applicability of the proposal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Making the Earth Global: Early Modern Nautical Rutters and the Construction of a Global Concept of the Earth' (RUTTER) under Horizon 2020.

assistant: **Objectives**

Early modern nautical rutters (sailing directions) are the earliest Western documents that testify to the stable and regular lived experience of traversing the earth’s oceans on a global, planetary scale. Nautical rutters (and ship’s loogbooks) are technical documents that collect and analyse critical information for the successful accomplishment of oceanic navigation. This includes elements of strict nautical nature (courses, distances, and latitudes), as well as information on oceanography (currents and tides), meteorology (winds and storms), geography, geophysics (magnetic declination) and the natural world. Their unique value lies not only in the fact that they are exceptional historical repositories of information about the world on a planetary scale but, more importantly, that they document the emergence of global concepts about the earth. In fact, no earlier documents contain information about the earth on a comparable worldwide scale. Thus, their historical value is peerless. Using these exceptional, yet poorly known sources, the main objective of this project is to write a narrative of the scaling up of a scientific description of the earth in the sixteenth and seventeenth centuries, from the lived experience of travelling and observing the earth in long-distance sea voyages. As a preliminary task, a systematic search, identification and classification of the information contained in early modern Iberian rutters and ship’s logbooks will be performed. This will be followed by an extensive multidisciplinary study of their content aiming at radically improving our present knowledge of the historical process that led to the formation of global concepts about the earth.


**Keywords:** Global environment, History of navigation, Climate History, History of Oceanograp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Strengthening Nanoscience and Nanotechnology Research at CEITEC' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The Czech Republic (CR) is one of the most industrial members of EU with the share of the industrial sector on GDP reaching 35 % and offering over 2 million jobs. However, to sustain and improve competitiveness in the future decades, this sector needs to absorb new trends and challenges in technologically demanding areas, especially in the Key Enabling Technologies representing a group of six technologies that are among the priority action lines of European industrial policy. Already now the KET-related production constitutes more than 20 % of the total industrial production of the CR, but its potentials is significantly higher. Within the project SINNCE, we aim at the strengthening of the KET-related nanoscience and nanotechnology research at CEITEC, a prominent research institution in the Czech Republic, which is a prerequisite for the future development of KET-related industry. The successful implementation of the SINNCE project and meeting its objectives will be verified by an increase in the key performance measurable indicators such as number of high quality publications, joint publications, invited talks, new scientific grant proposals, etc.The project SINNCE will link CEITEC with three research-intensive institutions around a Twinning Action. Those institutions, ETH Zurich, TU Vienna, and Weizmann Institute, are based in countries with a good performance in the KET-related industry and have experience with KET-related research. The successful implementation of the project is enabled by recent investments of EU FP7 programmes into CEITEC that brought its instrumental basis to a state-of-the-art level and directed the research performance of CEITEC to a growing trajectory. CEITEC is also identified within the Smart Specialization Strategy of CR as one of 5 Centres
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'IST-Africa Initiative (2010 - 2011) Regional Impact of Information Society Technologies in Africa' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

IST-Africa (2010 – 2011) is a collaborative Initiative between 1 European and 13 African partners, 11 Ministries & 2 National Councils responsible for ICT adoption, Science, Technology; Innovation policy and research in North (Egypt), Southern (South Africa, Namibia, Lesotho, Mozambique, Botswana, Mauritius), East (Tanzania, Uganda, Kenya, Burundi), West (Senegal) & Central Africa (Cameroon).Main objectives:· Strengthen research dimension of Information Society policy dialogues between the EC, African countries and regional organisations· Organise events in Europe and Africa synchronised with policy dialogue meetings, provide input on common policy & R&D priorities, opportunities & challenges and supporting the Information Society Track of the 8th Africa-EU Strategic Partnership· Identify and analyse African ICT policy & research priorities aligned with EU priorities, recommendations for future co-operation.IST-Africa (2010 – 2011) will achieve these goals through the following actions: a)  Organise 2 Ministerial level international research conferences & meetings with regional stakeholders in Africa; b)Undertake a survey of existing and emerging Living Labs in Africa and associated White Paper to provide a context for Living Labs and Living Lab Networks as a key priority of the 2nd Action Plan of the 8th Africa-EU Strategic Partnership; c) Organise 2 Workshops at European conferences; d) Document and analyse African ICT policies, engage Stakeholders to identify research priorities, recommendations for future co-operation; e) Organise Workshops to validate research priorities for future cooperation, create awareness of upcoming Calls; f) Strengthen international cooperation by promoting EU-African research cooperation under FP7-ICT, Capacities & People Programmes and g)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Application of recombinant dna technolgy to vaccination, diagnosis and epidemiology in tropical theileriosis' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The main objectives can be summarized as follows :* To develop ELISA based diagnostic assays using recombinant antigens which are specific to the sporozoite, macroschizont and merozoite / piroplasm stages of the parasite.* To undertake vaccine trials using available candidate recombinant antigens with the aim of developing a sub-unit vaccine. These studies include the objective of determining the optimum delivery system.* To investigate the ability of recombinant candidate vaccine antigens to potentiate the protection provided by attenuated cell line vaccines.* To fully analyze the diversity of the candidate antigens within an endemic region.* To extend and develop the study of the population genetic structure of Theileria annulata in Tunisia and Morocco.* To investigate the potential of attenuated vaccines to revert to virulence after tick transmission.* To assess the effect of attenuated cell line vaccination on transmission rates of the parasite by the tick vector and evaluate the effect on genotypic variation.Expected OutcomeThe work carried out in this project will lead to a full evaluation of the potential for developing a sub-unit vaccine based on existing recombinant antigens and determine whether a search for further antigens is required. A second outcome will be the development of sensitive diagnostic ELISA tests which potentially distinguish between vaccinated and challenged animals and can be used for routine diagnosis, epidemiological studies and post vaccination analysis. The ability of current cell lines to revert to virulence will be determined and, if they are shown to retain low virulence, this will provide assurance on the safety of large scale vaccination which, coupled with the analysis of post-vaccination tick transmission rates, will allow a bette