RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Targeting the elastic tissues ageing to improve the quality of ageing' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Ageing is accompanied by several age-associated' diseases, most of them involving tissue disorganization associated with a loss of tissue elasticity, with multiple physiological, mechanical and social consequences. The goal of this proposal is to target the ageing of elastic tissue to cope with ageing, or at least some manifestations of ageing. As the mechanisms that govern correct elastogenesis during development, which are lost in adulthood and ageing, are still unknown, and as it is also unknown how to reactivate these processes, the project introduces a coordinated action to find "positive modulators" (protection against degradation and post-translational modification, re-induction of optimal elastogenesis) of elastic tissue ageing.The originality of the proposal lies in the Coordination of strategies that will define:- Rodent and tissue-equivalent models to study the impact of therapeutic approaches on elastic tissue ageing- The development of diverse elastic fibre-derived peptides - proteoglycan conjugates based on the elastic fibre components structure and its alterations with age, in order to protect or delay elastic fibre degradation or post-translational modification- The development of strategies to assess neosynthesis of elastic tissues and to define biomarkers at the cross-roads between ageing and elastic tissue ageing. Assays on cells from humans displaying genetically-based "exaggerated" ageing will be used as indicators of the effectiveness of the selected "modulators". The expected impacts should be a breakthrough on skin and vessel ageing treatments with a special interest with the improvement of chronic vein insufficiency and, longer term, other disorders of joints, arteries and macula and the improvement of healing. The project brings together 12 par
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Hammam, aspects and multidisciplinary methods of analysis for the Mediterranean region' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Scenarios for the adaptive reuse of the Hammarn as a public service center for Mediterranean cities is the topic of the study HAMMAM. The Islamic bath house Hammam is a central place for social life and cultural heritage of the Medit. civilization with com plex urban and societal relations and various functions: besides its value as a cultural heritage, the Hammam is also an integrative part of the public life in the Islamic society and an example of architectural and cultural Mediterranean life, a place for semipublic activities, a space with specific architectural typologies, a support for health care and hygiene, a provider of drinking water, one of the rare public meeting places for women in the Islamic context, a place for relaxation and a place for reli gious, artistic and ceremonial activities. The HAMMAM project develops strategies and designs new concepts of adapting the old Hammam features to a contemporary Islamic life, at the same time assessing possibilities for a joint usage of the Hammam by the l ocal dwellers and tourists interested not only in architecture, but also in getting to know other life styles. The Hammam study uses a case study approach, which starts the investigation from the local situation (cultural, economical and technical) of 6 sp ecific Hammams in 5 different Medit. countries and one European country (Turkey) and develops sustainable user concepts for the different sites. A principal goal of this study is to understand and evaluate the function, the concept, the technology and the rules for the running of a hammam. Besides this study will assess risk factors arising during the revival process of traditional Hammams and carry out an users' risk assessment for a cultural heritage building that has a day-to-day usage. With the disappea ran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Role of the tubulin posttranslational modifications and microtubule severing protein, katanin in the cilia central pair assembly', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Cilia are microtubule (MT)-based external cell extensions that perform sensory and locomotory functions. Disruption of ciliary beating leads to human disorders such as infertility, airways diseases and hydrocephalus. The central pair of MTs (CP) apparatus is required for proper cilia motility yet the molecular mechanism that regulates its assembly is unknown. Loss of function mutations of MTs severing protein katanin or changes in the levels of MTs posttranslational modifications (PTMs) result in assembly of short immotile cilia that lack CP. Tubulin PTMs affect activity of katanin toward cytoplasmic MTs but the role of katanin and tubulin PTMs in ciliogenesis is unknown. Thus our main goal is to determine the role of katanin and tubulin PTMs and their reciprocal relationships during ciliogenesis, and their effect on the assembly and/or stability of CP MTs. We intend to identify katanin ciliary localization domain and ciliary interacting proteins. We will use a well established model to analyze motile cilia, a ciliate Tetrahymena thermophila. We will take advantage of high resolution microscopy for localization studies. We will perform mutagenesis analysis of katanin and b-tubulin in order to identified the key amino acid(s) involved in ciliary localization and interactions between these two proteins in cilia. To determine if defects in cilia caused by b-tubulin or katanin mutations can be rescued by parallel mutations in katanin and b-tubulin, respectively and restore disrupted protein interactions we will mutate katanin (or b-tubulin) and express under inducible promoter in wild-type and loss of function mutation background of partner protein. The outcome of the project will have likely medical implications. The project links different aspects of my postdoctoral resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Physiology of recombinant glucose-derepressed saccharomyces cerevisae strain'.

assistant: **Innovation**

Glucose repression in yeast represents a major problem for both the cultivation on industrial substrates and for the breadmaking (leavening) because glucose has to be depleted before the remaining sugars can be utilized. In glucose-derepressed Saccharomyces cerevisiae strains, simultanous, and concomitantly more time-efficient, utilisation of the sugars would be possible resulting in an improved process economy and a lower environmental burden beside better leavening characteristics. Several genes playing key roles in catabolite repression have been deleted in an industrial strain. The physiology of the recombinants will be compared with the wild type in well controlled high performance bioreactors in order to elucidate the respective gene functions in the regulatory cascade of catabolite repression. Measurements of extracellular sugars and metabolites, assays for sugar-cleavaging enzymes and uptake systems, Northern blotting and radioactive techniques will be the analytical tools providing the basis for a metabolic flux analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The origin of water in ocean island volcanism: correlating volatile and radiogenic isotope signatures in Atlantic OIB' (OIBH2O).

assistant: **Concept**

Volatile abundances and their spatial distributions provide important constraints on models of mantle melting, mantle convection and crustal recycling. The role of water is crucial especially for intra-plate oceanic magmas originated beneath a thick lithosphere, where small degrees of melting represented by many OIB, may only be possible due to its presence. However, the rarity of naturally quenched glasses at these locations has greatly limited OIB studies, and only scarce data are available. The present project will fill this gap, quantifying the amount of water in typical ocean islands, its control on melting and its implications for the origin of their sources. In this frame, the recent improvement of the analytical techniques for melt inclusions analyse s, has made them a powerful tool for investigation, since they preserve their original, un-degassed, volatile contents. H2O and CO2 contents, trace elements and Pb isotopes will be determined in olivine hosted primary melt inclusions from typical OIB from Canary (La Palma) and Cape Verde (Santo Antao, Fogo) islands. The selected localities display an isotopic composition with clear HIMU signature, which has been related to the presence of dehydrated oceanic crust. Thus, assessing the volatiles concentration s and their relationship to key radiogenic isotopic signatures in intra-plate OIB, will provide both major insight into the role of recycling in the mantle and its importance in controlling mantle melting away from the mid-oceanic ridges. Pb-Li isotope com position on whole rocks will also be measured, in order to investigate with novel isotopic tracers the relationship between volatile contents and the different isotopic signature of the mantle sources, and to put constraints on mantle convection and crustal rec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Human Brain Project Specific Grant Agreement 1' to be submitted under Horizon 2020.

assistant: **Abstract**

Understanding the human brain is one of the greatest scientific challenges of our time. Such an understanding can provide profound insights into our humanity, leading to fundamentally new computing technologies, and transforming the diagnosis and treatment of brain disorders. Modern ICT brings this prospect within reach. The HBP Flagship Initiative (HBP) thus proposes a unique strategy that uses ICT to integrate neuroscience data from around the world, to develop a unified multi-level understanding of the brain and diseases, and ultimately to emulate its computational capabilities. The goal is to catalyze a global collaborative effort. During the HBP’s first Specific Grant Agreement (SGA1), the HBP Core Project will outline the basis for building and operating a tightly integrated Research Infrastructure, providing HBP researchers and the scientific Community with unique resources and capabilities. Partnering Projects will enable independent research groups to expand the capabilities of the HBP Platforms, in order to use them to address otherwise intractable problems in neuroscience, computing and medicine in the future. In addition, collaborations with other national, European and international initiatives will create synergies, maximizing returns on research investment. SGA1 covers the detailed steps that will be taken to move the HBP closer to achieving its ambitious Flagship Objectives.


**Keywords:** mouse brain, human brain, transcriptome, simulation, reconstruction, neuroinformatics, biological, signatures of disease, high performance computing, neuromorphic computing, neurorobotics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Deal Engine, with finance, investment and technical expertise for the Circular Cities and Regions Initiative', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Effective investment and financing opportunities for circular economy projects in Europe are still few and far in between. Investors need to gain trust in circular economy projects. Projects need to become less risky and bankable, based on new and re-designed finance solutions and business models.  Transaction costs need to be decreased and the private finance community needs to be engaged to address legal, administrative and market challenges. The DEFINITE-CCRI project establishes a deal engine, providing technical, financial and circular economy expertise through local project development assistance in an unprecedented and streamlined process to cities, regions and project developers. The deal engine will be built with investors and finance partners and the goal to launch investments in four circular economy projects of up to EUR 20 million investment volume per project, amounting to a total portfolio volume of up to EUR 80 million. The DEFINITE-CCRI will demonstrate the bankability of high-impact circularity projects and increases maturity and investor trust in circular economy innovation. It closes the gap between project developers in cities and regions on one side, and investors and finance partners on the other. The DEFINITE-CCRI project co-creates and proves an end-to-end PDA process, aggregating risk-mitigation, EU Taxonomy compliance, circularity criteria and technical and financial engineering in a single project development service for the CCRI’s service portfolio. Partners commit to operate the deal-engine sustainably beyond the project lifetime. This will inject the financial, technical and managerial know-how into urban circular transitions and ultimately contribute to lower virgin non-renewable material use, lower GHG emissions and more just and inclusiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Coherent, Acceptable, Low Emission Cultural Heritage Efficient Renovation' (CALECHE), addressing dissemination and exploitation.

assistant: **Impact**

Historic buildings represents a considerable share of the European building stock (around 25%). They contribute to the identity and uniqueness of many cities and will only survive if they are maintained as a living space. To preserve a living built heritage, it is necessary to find energy renovation approaches and solutions compatible with conservation rules. This means that the historical and aesthetic value of these properties must be preserved while increasing the comfort of these living spaces, and minimizing their energy consumption and their environmental impact.The project aims to establish new knowledge for the development of sustainable and efficient solutions for historic buildings in order to bring cultural heritage to life and make it open, accessible, inclusive, resilient and low-emission. It is part of the pursuit of various projects involving members of the CALECHE network concerning, for example, bio-sourced renovation or ""custom"" PV integration. The studied solutions will cover all stages of operation (prevention, monitoring, maintenance) and renovation (setting up the operation, design, works).""


**Keywords:** Cultural Heritage Renovation, Multi-Benefit Renovation, Sustainable Use of Heritage Buildings and Districts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Building EnergY WATCHer' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Targeting environmental sustainability, energy efficiency and new power distribution business models, BeyWatch aims to design, develop and evaluate an innovative, energy-aware, flexible and user-centric solution, able to provide interactive energy monitoring, intelligent control and power demand balancing at home, block and neighbour level.The system will interconnect legacy/consumer electronic devices with a new generation of energy-aware white-goods in a common network, where multilevel hierarchic metering, control, and scheduling will be applied, based on power demand, network conditions and personal preferences. By scheduling and controlling the electronic devices operation, BeyWatch aims to minimize power distribution peaks, balancing energy load in power distribution networks and ultimately achieving predictable large-scale energy-consumption profiles. Moreover, BeyWatch will integrate an innovative combined photovoltaic/solar (CPS) system, which will provide hot water for white goods in order to reduce/remove the energy-hungry heating operational cycles and generate electrical energy, which can be utilised at home, or during peak periods even fed to the electricity network in a reverse power generation/ distribution business model.BeyWatch proposed solution combines innovation in six areas:a) Technologies for very low-cost white goods' power consumption. Incorporate ultra-low power motor control and FET technologies (refrigerator) and removal/ reduction of the heating phases by using hot-water available from solar energy and smart cycles (washing machine, dishwasher).b) Mechanisms and standards for in-home ultra low-cost communications. Select the most appropriate technology and protocol for seamless, reliable and ultra low-cost in-home communication and control
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Medium scale surface temperature mission' in the context of a Fourth Framework call.

assistant: **Objectives**

The objective of this proposal is to promote a medium resolution thermal infra-red imager mission, named Medium Scale Surface Temperature (MSST). The main applications of measurements from space in thermal infrared range are related to soil and plant energy budget related questions. It has been shown that thermal emission from an agricultural surface can be used to retrieve parameters directly related to the hydric state of the soil/vegetation system. These parameters are most important to be known if one wants to get information on water availability or vegetation state, potential stress due to drought, illness or other pests. In addition several other applications have been developed, using the surface temperature as a direct information, such as mapping of frosted agricultural areas or of heat islands on urban surfaces. Presently, the most widely known space sensor providing thermal IR data on a routine basis is the AVHRR instrument on board NOM satellites. It is used by a large community and has strongly contributed to develop research works on thermal data. It has 2 thermal channels and ensures a global coverage with a 1.1. km spatial sampling. This low resolution necessarily limits the extent of applications as they remain mostly global., More recently, applications based on previous work completed with AVHRR data have been developed at a higher resolution using 1 20-m resolution Landsat TM thermal infrared data (in particular for irrigation and forest fire risk monitoring), and have shown a real need and interest for medium-high products. However the Landsat TM swath width is 185 km, and due to a single thermal channel, it needs complementary in-situ measurement in order to determine the surface emissivity of the acquired zones. These are the reasons why it is pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The contribution of urban greenspace to quality of life (GREENSPACE)' (GREENSPACE) under Fifth Framework.

assistant: **Objectives**

Many European cities possess attractive parks or recreational areas. This research will draw on the complementary skills of European researchers and planners to develop applied methodologies to establish what variety of greenspace" best satisfy people's needs. It will demonstrate, using case studies, how public participation can be brought to a strategic approach to greenspace on a continuing basis. Green space makes an essential contribution to the quality of life and as attracts both people and commercial investment. Yet green space is often not given the same priority as other calls on public funds. The portfolio of green space is often a legacy of earlier decades and in few urban areas has the planning development of parks , greenways , recreation areas and nature reserves been approached in a comprehensive manner such as that proposed."