RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DEVELOPMENT OF AN OPTICAL BACKSCATTER SENSOR FOR DETERMINING THERMAL DENATURATION OF WHEY PROTEINS DURING MILK PROCESSING', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The heat denaturation of whey proteins impacts the functional properties of milk. After denaturing, β-lactoglobulin (β-LG) associates with κ-casein (κ-CN), a protein located in the surface of the casein micelle. This association significantly impairs milk coagulation by creating a steric obstacle for κ-CN hydrolysis −a critical phenomenon initiating coagulation− and by increasing the gel moisture retention. Correlations of the degree of β-LG denaturation to gelation time, gel firmness, and gel moisture content have been widely documented. The resulting high moisture and soft gels are undesirable for cheese manufacture but advisable in yogurt processing, as it aids in preventing one of its most frequent defects, wheying-off.  Early prediction of the potential gelling strength of milk will allow milk batches to be used for their most suitable purposes. The economical impact this would have on the dairy industry, in addition to the non-existence of a simple method of protein denaturation measurement, motivates this research. The goal of this project is the development of an optical sensor technology for inline determination of β-LG denaturation and subsequent association with κ-CN during milk heat treatment. Given the scattering properties of the micelles, light backscatter was chosen for optical measurement. Preliminary experiments indicate that light backscatter response is proportional to heat treatment intensity, which suggests that light scatter could be used to determine the whey protein denaturation degree. The development of the proposed sensor technology will require: a) finding the adequate wavelength/s, b) developing a robust prediction algorithm, and c) obtaining chemical data supporting the observed optical responses. Successful development of this optic senso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Decoding the Mammalian transcriptional Regulatory code in development and stimulatory responses' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Transcription factors (TF) regulate genome function by controlling gene expression. Comprehensive characterization of the in vivo binding of TF to the DNA in relevant primary models is a critical step towards a global understanding of the human genome. Recent advances in high-throughput genomic technologies provide an extraordinary opportunity to develop and apply systematic approaches to learn the underline principles and mechanisms of mammalian transcriptional networks. The premise of this proposal is that a tractable set of rules govern how cells commit to a specific cell type or respond to the environment, and that these rules are coded in regulatory elements in the genome. Currently our understanding of the mammalian regulatory code is hampered by the difficulty of directly measuring in vivo binding of large numbers of TFs to DNA across multiple primary cell types and their natural response to physiological stimuli.Here, we overcome this bottleneck by systematically exploring the genomic binding network of 1. All relevant TFs of key hematopoietic cells in both steady state and under relevant stimuli. 2. Follow the changes in TF networks as cells differentiate 3. Use these models to engineer cell states and responses. To achieve these goals, we developed a new method for automated high throughput ChIP coupled to sequencing (HT-ChIP-Seq). We used this method to measure binding of 40 TFs in 4 time points following stimulation of dendritic cells with pathogen components. We find that TFs vary substantially in their binding dynamics, genomic localization, number of binding events, and degree of interaction with other TFs. The analysis of this data suggests that the TF network is hierarchically organized, and composed of different types of TFs, cell differentiation facto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Testing Methods for Electrical Apparatus installed in a dusty Environment with a potential Risk of Explosion' (1994-1998).

assistant: **Concept**

ObjectivesThe objective of this project is to study dust clouds and layers and define practical test methods for the ignition capability of specific electrical apparatus in these environments. A series of tests will be performed and following an analysis of the results, a proposal for reproducible test methods will be drafted. Any laboratory in Europe dealing with these matters should be able to perform these tests and produce reliable and reproducible test data.State of progressThe kick-off meeting between participants has been held and test-houses have been contacted for information on test methods currently in use. Literature surveys have been started and preliminary ideas on the design of tests discussed.BackgroundEuropean standards that support the directive 94/9/EC - the ATEX directive - need to cover the potential risk of explosion or fire of clouds and layers of explosible dusts. CENELEC TC31 requires practical test methods for electrical equipment installed in environments where clouds and/or layers of combustibles are present.The application of intrinsically safe break-flash" testing to dust clouds is not established, and there is no standard test for either low voltage or high voltage circuits. Neither are tests available for situations where thick dust layers or deposits may accumulate and present an ignition risk.This project will address these important gaps in knowledge, and lead to the development of accepted test methods.WorkprogrammeCurrent test methods for ignition by hot surfaces and electrical sparks of dust clouds, layers and accumulations will be identified, with consultation with at least three major manufacturers and users of equipment.The test conditions will be compared with conditions likely to be met in practice, and the characteristics of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'How do pathogens exploit the symplast to promote disease?' in the context of a Horizon 2020 call.

assistant: **Objectives**

It is well established that pathogens invade plant cells to establish an infection. Part of a biotrophic pathogen’s infection strategy is to secrete effectors into host cells in order to manipulate host processes to the pathogen’s benefit. It has been observed that some effectors can move from cell-to-cell in the host and this suggests that a pathogen can invade and exploit cells surrounding the immediate infection site. To further support this hypothesis, my host lab observed that PAMP-induced plasmodesmata (PD) closure is suppressed in some virulent infections, suggesting pathogens attempt to keep intercellular connections open; some pathogens must maintain intercellular symplastic connectivity by counteracting PAMP-induced PD closure to promote disease. This proposes the question: why does a pathogen want PD open? We hypothesise that open PD allow pathogen effectors to move into non-infected cells where they targeting host processes to promote infection and allow pathogen access host resources such as sugars. In this study, I will use the Hyaloperonospora arabidopsidis– Arabidopsis interaction to identify cell-to-cell mobile effectors and their host targets. I will identify global changes of host gene regulation that are associated with cell-to-cell mobile effectors and examine the effect of cell-to-cell mobile effectors on sucrose transport around an infection site. The results will give insight into how pathogens exploit the symplast and non-infected cells to promote infection, characterising a poorly considered element of plant-pathogen interactions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ENVIRONMENTAL ANALYSIS AND RESILIENCE FOR TRANSFORMATIVE HUMAN-OPTIMIZED NATURAL ENVIRONMENTS' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The mission of EARTHONE is to address the pressing issue of preserving and enhancing Earth's natural terrestrial GHG sinks by understanding how different drivers, including socio-economic, demographic, and physical constraints affect GHG fluxes. The project adopts a unique and interdisciplinary approach, integrating state-of-the-art data-driven technology with regional context (with a special focus on the most vulnerable areas in south and Mediterranean Europe including Spain, Greece, Italy, Slovenia, Croatia and North Macedonia) through living labs to offer effective multi-target solutions and guideline to all stakeholders in LULUCF topics.


**Keywords:** land use, land use change, climate change, phenology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'From Research Optoacoustic Novelty To Imaging Established in Routine diagnostics' (FRONTIER).

assistant: **Concept**

Multispectral optoacoustic tomography (MSOT) is an innovative biomedical imaging technology that allows for molecular imaging in deep tissue. This noninvasive technology enables assessment of the concentration and distribution of a variety of clinically important molecules in the body and uniquely delivers information of e.g. oxygenation, inflammation, and fibrotic changes. MSOT has already demonstrated significant scientific and clinical value across a range of diseases and applications, making it a promising tool to diagnose diseases and monitor treatment response. Despite these early successes, the technology is not yet commercially viable on the broad clinical market and currently remains effectively confined to a research environment. FRONTIER will provide iThera Medical the means to translate an optimized MSOT system (MSOT Frontier) from a research environment to application in routine clinical imaging, thereby providing clinicians worldwide a powerful new diagnostic tool.


**Keywords:** Optoacoustic imaging,Biophotonics,Biomedical imaging,Breast cancer,Neuromuscular disease,Inflammatory bowel disease,Noninvasive imaging,Molecular imaging
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enhance innovation management capacities in Andalusian SMEs. CESEAND InnoAses 2015-16.' in the context of a Horizon 2020 call.

assistant: **Objectives**

The European Commission has placed a firm wager on an ""industrial renaissance"" in which SMEs are to play a leading role. Within this context, the role the new Community instruments have assigned to the Enterprise Europe Network, as a European-wide network of entities integrated into regional innovation systems, is that of being the lever and driving force for innovation management capacities in SMEs and, in the near future, as the organisation directly responsible for the provision of advanced services.Innovation properly combined with cooperation and internationalisation, is the only path along which SMEs can improve their competitiveness in a globalised world undergoing an industrial crisis.Therefore, our main objective is to contribute to smart growth in Andalusia, through the provision of services enhancing the innovation management capacities of Andalusian SMEs. According to this call, these are the Project's Objectives expected to be attained through this project's development and implementation:• To enhance the innovation capacities of SMEs in Andalusia in order to make them more competitive through the provision of advanced services.• To drive forward non-technological catalysts for innovation in SMEs.• To develop on behalf of the entities which comprise the Enterprise Europe Network new ways and tools to provide services to SMEs that contribute to enhancing their competitive capacities.• To provide support to beneficiaries of SME Instrument, accompanying them in their transition through Phases 1 and 2.• To identify future potential applicants to successfully take part in SME Instrument.• To develop methodologies that can be enhanced through their integration into the Andalusian Innovation Ecosystem.""


**Keywords:** Action:  Establishing services enhancing t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'High performance inorganic membranes for pervaporation and vapour permeation technology (inmemperv', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The idea of the proposal is to solve problems related to use of inefficient energy and chemical consuming separation technologies in chemical industry. The technological objective is to develop inorganic microporous membranes and modules for pervaporation and vapour permeation, which will result in a broad application range of these significantly more efficient separation technologies. This objective will be achieved by developing stable microporous inorganic membranes on different types of membrane support, which can be assembled in membrane modules capable of operating with performance specified by chemical industry. Targeted goals for the developed membranes and modules are: Membrane water flux: 7 kg/(m2/bar/ h), selectivity = 1000 (azeotropic ethanol/water mixtures at 100c, ph stzability range 2-12, temperature stability up to 300°C, pressure 30 bar, membrane price: <1500 EUR/m2, and module size: 10-50 m2. An exploitation plan will be made.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'International Doctoral Programme in Molecular Mechanisms of Disease' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

The International Doctoral Programme in Molecular Mechanisms of Disease (iMED) will recruit 24 international doctoral fellows to Biotech Research and Innovation Centre, University of Copenhagen. iMEDs VISION is that the next generation of researchers should possess the abilities to perform and connect excellent science to exploitation and value for the surrounding society. Our MISSION is to foster a cohort of excellent fellows through a personalized research and training programme, ensuring that they exploit the full potential of their talents. iMEDs procedures and activities will provide a structural and intellectual framework for the fellows to develop strong research and transferable skills and empower diligence, ambition and creativity, as well as competences to build their individual research career. We will implement interdisciplinary research projects, transnational mobility and intersectoral exposure, ensuring improved employability of fellows across fields, borders and sectors. The EU Principles of Innovative Doctoral Training and the Code of Conduct for the Recruitment of Researchers serve as a platform for iMED and form the ground for the programme aims: ensure transparent merit-based selection of candidates, 2) nurture development of excellent interdisciplinary research competences, 3) ensure inter-sectoral exposure, 4) ensure international networking, 5) provide transferable skills training and a personalised career development programme and 6) provide timely expert supervision and mentoring. Three private Partner Organisations will supply transferable skills training and career activities. An alliance of 13 top life science research institutes will provide secondments, co-supervision and PhD courses. Four international experts will participate in the selec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Switchable adhesives for the robotics and handling market' (SWITCH2MARKET).

assistant: **Innovation**

Despite intense fundamental research, only few biological inspirations have so far made it to real technical solutions. The reason is that the path from an understanding of nature to a successful product has many potential ´show stoppers´. The ERC Advanced Grant SWITCH2STICK addresses the scientific challenges and does not aim at product development and targeted technical optimization towards industrial requirements. Some preliminary industrial contacts, established through bilateral communication, have resulted in extremely promising perspectives for a commercialization of our results.From a technical perspective, our bioinspired concept could revolutionize robotic pick-and-place (handling) operation. The timing appears to be excellent: as new concepts for computerized, virtual fabrication are currently being developed on a worldwide scale, the readiness for implementing new concepts is at an all-time high. When combined with its clear environmental advantages (energy-conserving, noise-free), our invention has overwhelming market potential in the handling of production elements, e.g. electronics, optical components, or in the automotive sector. Preliminary screening suggests that our invention is well IP-protected for future commercialization. The proposed PoC project will tackle the essential issues that remain to be clarified before launching an extensive commercialization activity, including i) competitive analysis, ii) identifying the most promising markets, iii) testing the performance with regard to special requirements lists from industry, iv) developing a well-founded IPR strategy, v) generating a detailed business plan. The results will enable us to enter into targeted bilateral collaborations with leading industrial companies under full protection of our own
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Self-assessment Oracles for Anticipatory Testing'.

assistant: **Objectives**

One of the long-lasting dreams in science fiction is the ability to arrest criminals before they even commit crimes. Software testing researchers have a similar dream: when the context for a bug manifestation occurs in the field, the goal is to discover and fix the bug before it causes any in-field failure. In fact, current practice of pre-release testing is severely limited when dealing with autonomous AI (Artificial Intelligence) systems (such as self-driving cars, robots, automated traders, virtual doctors and customer service chatbots), running in complex, rapidly changing environments, which cause their run-time adaptation, learning and knowledge acquisition, because pre-release testing cannot exhaustively explore all different contexts and states in which the software will be running.The PRECRIME project introduces a new, disruptive view on testing, called anticipatory testing and aimed at fixing bugs before they even manifest themselves in the field. Anticipatory testing is activated at run-time by a new type of oracles, called self-assessment oracles, which observe and report unexpected execution contexts. A self-assessment oracle is an estimator of the system’s confidence in being able to handle a new execution context correctly. The goal of anticipatory testing is to anticipate any failure that might occur in the field due to unexpected execution contexts. Whenever an execution context monitored at runtime by self-assessment oracles is estimated as a low confidence context for the system, anticipatory testing exercises the software automatically and extensively in similar contexts. Timely activation of anticipatory testing by runtime observations results in early, anticipatory fault detection. Combined with automated patch synthesis, anticipatory testing leads