RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Analysis of epigenetic reprogramming during germ cell development' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

Many biological processes are established by transcriptional control mechanisms, which involve reversible chromatin modifications. Mainly the interplay between methylation and acetylation of histone tails defines the epigenome of a given cell type. Stem cells must maintain pluripotency, and their differentiation potential relies on the plasticity of their epigenome.The mammalian germ line originates from a group of differentiating somatic precursors, implying that developing germ cells must reprogram their epigenetic settings to enable totipotency after conception. Primordial germ cells (PGCs) undergo both, DNA demethylation and dynamic changes of repressive histone methylation marks at histones H3 and H4.Thus, PGC differentiation represents a natural system to analyze epigenetic plasticity and the established mechanisms will provide understanding of stem cell identity. The proposed study aims to define biological functions of selected histone methyltransferases (HMTs) during germ cell development. Firstly, work in the hosting institute defined histone tail methylations that are hallmarks of differentiating germ cells.Analysis of PGC-specific gene deficient animals for the respective known HMTs Ezh2 and PR-Set7 will reveal the contribution of histone methylation to germ cell development and, in particular, to epigenetic reprogramming. The underlying molecular mechanism will be investigated by microarray-based identification of direct target genes. Secondly, expression analyses identified a small group of putative HMTs that are selectively expressed in stem cell entities.We will reveal their spatiotemporal expression patterns and their histone target specificities. RNAi mediated ablation will address their function in ex vivo germ cell differentiation. Our work will reve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Characterisation Of A Green Microenvironment And To Study Its Impact Upon Health and Well-Being in The Elderly As A Way Forward For Health Tourism.' (CHARMED) under Horizon 2020.

assistant: **Objectives**

Our society in Europe is still under prepared for the demographic changing situation of an ageing population which began several decades ago. This is visible in the age structure of the population and is reflected by the fact that the population aged 65 years and over is increasing in every European country. The growth in the elderly population may be explained by increased longevity, but at the same time, we also see an increase in debilitating conditions. However, it is also clear that the elderly are afflicted by challenging health conditions as a direct consequence of being elderly which impact their quality of life (QOL), e.g. living alone, depression, recovery from illness, immobility. This is what we would like to address. Living longer should be a privilege but there has been a collective failure to address social implications and QOL issues, where social care and the way it is funded are already in crisis. Our aim in this project is to couple the need for new societal approaches in addressing this changing demographic with improving the economy of green microenvironment sites, where health tourism and creating new jobs in this sector would in turn fund and provide benefits with respect to the well-being of the elderly. The ultimate outcome, through this pan-European academic and industrial project, will be: a) to derive cross-disciplinary and inter-sectorial knowledge of how to improve physical and mental well-being in the elderly, b) to characterise the environmental geology of Nemi and to correlate the identified features with improvements in health, well-being and recovery, c) to train a new generation of specialists in the sector of recreation and health for the tourism industry, d) the training of specialists in social and therapeutic horticulture (STH) as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Uncertainty Prediction & Bias Elimination in Aviation Technology for Safety' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Understanding and quantifying uncertainties (UQ) in aviation structures is vital to assessing risk and safety. UPBEAT will create novel UQ methods and tools to support the production of safer and more innovative aircraft structures and engines while reducing uncertainties in product and engineering lifecycles. The project focuses on metal-composite hybrid aerospace engine parts that are lighter, more durable and cheaper. Innovative design solutions for hybrid interfaces can be achieved using metal additive manufacturing (AM) bonded with carbon fiber reinforced polymers (CFRP). Advanced models of materials and processes will be developed using sophisticated in-situ and ex-situ monitoring and metrology. In aviation engines, the outlet guide vane (OGV) is an essential component that helps de-swirl the flow field from the fan. The OGV's stiffness is crucial as it influences the engine's performance and includes a major load path from its core to the wing. The OGV with two types of CFRP vanes and titanium end fittings will be used as a demonstrator. By combining AM with advanced in-situ melt pool monitoring and characterization (micro-CT & nanoindentation), digital models will be used to optimize design and manufacturing processes and increase awareness on efficiency, safety and risk. This will result in 20-40% weight reduction and 50-70% fewer defects. Streamlined product development reduces qualification time by 30-40% and costs by 25-35%. In-line quality assurance support lowers manufacturing costs by 30-50% and time by 20-30%. UPBEAT will: ✔ Increase understanding of the process, structure, property, & performance with safety focus ✔ Advance process models (AM, CFRP) for planning & optimization ✔ Develop verification and validation using multi-scale models ✔ Integrate UQ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structure/function relationships of the genes and proteins encoded within the human natural killer cell receptor complex' (1994-1998).

assistant: **Innovation**

The objectives of the proposed study include: 1- To isolate a set of yeast artificial chromosome (YAC) clones encompassing a region of human chromosome 12 containing several families of known and potentially novel NK cell receptor genes 2- To isolate representative members of each family, map their chromosomal location and analyze their expression in subsets of NK cells at the gene and protein level 3- To study the role of selected members of the individual families in NK cytotoxicity assays and to analyze the intracellular signalling pathways triggered by the receptors 4- To determine the structures on target cells to which these receptors are binding, especially to which extent specific carbohydrates, glycoproteins and/or MHCI haplotypes are the ligands Brief description: A significant fraction of blood leucocytes are large granular lymphocytes. Because of their ability to spontaneously kill certain tumour cells and virally infected cells without prior sensitization, these cells are known as natural killer (NK) cells. They appear to be important for the resistance to growth and metastatic spread of tumours and for natural immunity against viral infections. In addition they have been implicated in bone marrow graft rejection Whereas the antigen-recognising receptors and the corresponding genes of B and T Lymphocytes have been well characterised within the last decade, the precise nature and function of the NK cell receptors mediating the recognition of aberrant cells remains to be elucidated. Several laboratories, including our have recently described and analysed candidate proteins in humans and the rodent system. Most of these potential NK cell receptors can be grouped in several sma families and share common structural features, including a type ll transmembran orie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Disaggregated Recursive Datacentre-in-a-Box' (2014-2020) under Horizon 2020.

assistant: **Objectives**

For all the superior features that low-power computing systems exhibit compared to conventional high-end server designs, there is a common design axiom that both technological trends are based on: the main-board and its hardware components form the baseline, monolithic building block that the rest of the hw/sw stack design builds upon. This proportionality of compute/memory/network/storage resources is fixed during design time and remains static throughout machine lifetime, with known ramifications in terms of low system resource utilization, costly upgrade cycles and degraded energy proportionality.dReDBox takes on the challenge of revolutionizing the low-power computing market by breaking once and for all server boundaries through materialization of the concept of disaggregation. Through a highly modular software-defined architecture for the next generation datacentre, dRedBox will specify/design/prototype modular blocks for SoC-based microservers, memory and accelerators, interconnected via a high-speed, low-latency opto-electronic system fabric, and that can be allocated in arbitrary sets, as driven by fit-for-purpose resource/power management software. These blocks will employ state-of-the-art low-power components and be amenable to be deployed in various integration form factors and target scenarios.dRedBox aims to deliver a full-fledged, vertically integrated datacentre-in-a-box prototype to showcase the superiority of disaggregation in terms of scalability, efficiency, reliability,performance and energy reduction. The prototype will be used as vehicle to demonstrate the value of dReDBox in 3 pilot use-cases stemming from three market segments: Security, Network Analytics and Telecom. With an industry-lead consortium comprising top academic experts too, dReDBox i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Support to the Vice-Presidents of the ERC Scientific Council 2020' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The European Research Council (ERC) provides a competitive platform for investigator-driven frontier research at the European level. It is led by a Scientific Council (ScC) consisting of 21 eminent scientists and their President, and it is this council that independently establishes and oversees theERC's scientific management and the implementation of its Work Programme. This project aims to support the ERCVice-Presidents, who act on an honorary basis, in the efficient and timely achievement of the ScC's goals in 2020.This project will provide local administrative and advisory support to the three ERC Vice-Presidents.The staff supported by this project will provide analysis of the output of the ERCand the ScC to the Vice-Presidents, preparatory work for the meetings of the ScC, support with scientific outreach and representation, as well as maintaining a clear and efficient channel of communication between the Vice-Presidents and the ERC's Executive Agency. A key duty of the Vice-Presidents is maintaining the integrity of the ERC's evaluation panels, and the staff supported by this grant will facilitate this by providing detail information and analysis of potential panel members to the Vice-Presidentsto allow them to take informed decisions on recruitment.The staff will also coordinate the invitation of new panel members and communicate with them during the recruitment process.The impact of the project will be to ensure the efficient and well-managed operation of the ScC. This support is required, as the duties of the Vice-Presidents demand a considerable portion of their time. By allowing the Vice- Presidents to effectively and efficiently perform their duties, this project will contribute significantly to the continued implementation of the ERC under Horizon 2020.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Single-spin electron resonance'.

assistant: **Innovation**

The goal of this project is the manipulation of spin properties of quantum dots by microwave signals. We will use a high-Q microwave cavity, developed in ETHZ, in order to maximize the magnetic field strength at the location of the quantum dot and keeping the total power of the microwave below the cooling power of the dilution refrigerator. The focus will first be on electron spin resonance, then we will study the possibility to manipulate spin states by GHz pulses in order to prepare well-defined spin states.We will develop the crucial components and set up the microwave experiment. Then, the goal is to detect single-spin resonance following recent theoretical proposals. This project will allow growth in scientific prospective both: of the researcher and of the host institution, which in its turn should enhance EU scientific excellence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A european farm animal biodiversity information system' (EFABIS), addressing dissemination and exploitation.

assistant: **Impact**

The objective of the project is to create an integrate infrastructure of databases to monitor farm animal biodiversity (FAB) in Europe. This project will meet the specific requirements of the European continent as well as the need for full compatibility with the Global Information System (DAD-IS) of FAO. The outcomes of the project will be made available to the widest range of potential users. It will be an important tool in characterisation, utilisation and conservation of those genetic resources. The project will help rationalise the monitoring of livestock and poultry genetic diversity, and favour a greater awareness of the genetic resources available to the European farmers. The new European database structure will help the countries in collecting information on the one hand and will be integrated with DAD-IS, which is designed to link all parties to the FAO Global Strategy for the Management of Farm Animal Genetic Resources.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Armenian Trading Communities between Amsterdam and Venice, 1650-1730' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Armenian merchants, translators, and brokers were critical actors in the global trade of luxury goods between Asia and Europe in the seventeenth and eighteenth centuries. They were able to move and settle in cities across Europe with relative facility, facing comparatively fewer political barriers than Jewish or Muslim traders due to their status as a Christian-majority trading group. However, the current historiographical picture of these communities in Western Europe has not adequately illustrated or understood the complexity of what trading community really meant for Armenians, and other mobile minorities; it often assumes a level of cultural cohesiveness within these groups. How should we understand the concept of community when it is shaped by circumstance, conducted over distance, formed of both transient and settled members, and interacts with the host environment? This project investigates this question by a comparative analysis of the Armenian communities of early modern Amsterdam and Venice, and the un-explored mercantile networks between them. New archival research redresses the historiographical neglect of these two communities and their connection to shed new light on the conceptual and practical formation of trading community. Integrating the theoretical paradigms of social and spatial mobility, and crossing the disciplines of history, sociology, and human geography will advance a new nuanced concept of minority community from the early modern period to the present.


**Keywords:** 17-18th centuries,  merchants,  trade,  political negotiation,  cultural identities,  trading diaspora,  minority communities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'polyValent mEsopoRous nanosystem for bone DIseases'.

assistant: **Innovation**

Finding simple solutions to complex problems has been a challenge for humankind for decades. VERDI aims at designing a multifunctional nanosystem to heal complex bone diseases. This is an engineering challenge that will be tackled through the use of building blocks designed on the basis of cutting-edge technology. These building blocks will be assembled into a versatile multifunctional nanosystem that can be adapted through slight variations for the treatment of three diseases of clinical relevance: bone infection, bone cancer and osteoporosis. The novelty of this proposal is the design of a nanosystem that may address several diseases using a unique, versatile and scalable strategy. Mesoporous silica nanoparticles are selected as the main component of the nanoplatform because of their biocompatibility, robustness, loading capacity and versatile surface modification. The nanosystem will be modified by rational selection of building blocks, with targeting and/or therapeutic abilities, to tackle either one or a combination of pathologies. These features will enable us to deliver a library of nanomedicines using a toolbox of building blocks, customizing a specific nanosystem depending on the disease to be treated. The risks associated to VERDI are numerous, such as the great complexity of producing completely asymmetrical nanoparticles (NPs), the risk that modifying a drug or therapeutic peptide will affect its therapeutic efficacy, and the difficulty of achieving effective in vivo bone targeted NPs. A contingency plan for each risk has been elaborated. The expertise and capacities of my research group guarantees successful results, which we expect to lead to a revolution in the therapy of bone cancer, bone infection and osteoporosis. Additionally, the application of a sin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Nanoparticle and Multielement Quantification in Single Cells: Exploring New Analytical Methods'.

assistant: **Innovation**

Genetically identical cells observed as a population can be significantly heterogeneous when studied individually, and this heterogeneity can change the behavior of entire cell populations. In particular, some trace elements play important roles in cell processes. Classical analytical methods to measure (trace) elemental composition in cells (naturally present or taken up by them, e.g. nanoparticles) provide information only about the average of the cell population thus disregarding important cell-to-cell variances. In this context, single-cell inductively coupled plasma-mass spectrometry has been gaining special attention to evaluate elements and nanoparticles as well as multiparameters in single cells. However, our currently available information and quantitative data on multielemental composition and uptake of toxic elemental species and metal oxide nanoparticles in single cells are still scarce. NanoMuSiC project will develop new sensitive and accurate analytical methods based on the coupling between a microdroplet generator to the state-of-the-art inductively coupled plasma-time of flight-mass spectrometry for multielement quantification and for evaluating the uptake of elemental species and metal-based nanoparticles in single cells. These methods will be applied to proof-of-concept ecotoxicological applications employing diatoms (single cells) and environmentally relevant elemental species and nanoparticles. Through these developed methodologies and results, the NanoMuSiC project will provide new insights on cellular elemental composition and elemental species-cell and nanoparticle-cell interactions. Besides, they will support further investigations of effects and potential risks of elemental species and nanoparticles to the environment and human health, two relev