RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Understanding how long non-coding RNAs adapt the adipocyte for specialised lipid storage and breakdown.' (LNC-LIPID).

assistant: **Innovation**

Energy is stored in adipocytes as a large uniocular lipid droplet, which can be broken down into fatty acids (FAs) and released into the circulation when needed. This specialised lipid storage and breakdown requires dynamic organisation of metabolic enzymes and cofactors around the large lipid droplet for metabolic homeostasis. In obesity, the adipocyte dysfunctions, resulting in high spontaneous release of FAs. This chronic release and elevation of systemic FAs is a major driver of systemic insulin resistance, type 2 diabetes and other cardiometabolic diseases.I postulate that long non-coding RNAs (lncRNAs) interact with the metabolic machinery within the adipocyte to organize cell- and stimulation-specific interactomes, channelling substrate flux within the cell. Adipocytes express over 4000 lncRNAs, many of which are unique to humans and this cell type. However, whether these lncRNAs contribute to the adipocyte’s specialised lipid metabolism in health and disease is not understood. This proposed research aims to address this question.I have already developed key methodologies to study lncRNAs in human adipocytes, including a novel technique called TROOPS that identifies specific lncRNA-interacting proteins. Leveraging an extensive bank of white adipose tissue biopsies from uniquely characterized patients, I will identify disease-regulated lncRNAs and test how they function in human adipocytes. I will use gene editing techniques and lipid/metabolomics analysis to define the role of these lncRNAs in lipid storage and FA release.Furthermore, I will use protein-lncRNA complex purification combined with advanced microscopy techniques to reveal how lncRNAs can sequester protein complexes into phase-separated organelles and organize adipocyte lipid metabolism. These insight
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'TOTALLY RENEWABLE, ENVIRONMENTALLY ENHANCED PRODUCTS, LIFECYCLEWIDE ADAPTED TO SUSTAINABLE TARGETS' (TREEPLAST) under Fourth Framework.

assistant: **Objectives**

The share plastic products hold within consumer goods is continuously rising. FASAL is a new material, totally based on renewable raw materials, especially wood, corn-flour and natural resin that proved suitable for being manufactured with conventional injection moulding machines. Injection moulding technique allows to produce parts with complicated geometric shapes. It is therefore possible to use the economic advantages of plastic manufacturing Furthermore it is possible for plastic manufacturing companies to shift to renewable resources with. The material properties of the new biopolymer differ from conventional plastics in some aspects especially biodegradability, appearance and to some extent water sensitivity. Research is necessary in optimisation of material properties and in injection moulding with biodegradable and renewable raw materials. Furthermore in order to fully utilise the advantageous properties of the material new design methodologies have to be found to ensure improvements in functionality and environmental performance of the products. Not only the replacement of plastic products but also the use of the new material for appropriate purposes is an important goal of the research. The final products have to find their own way through better design and engineering and better material applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'A Novel 3Rs Microphysiological Alternative Platform for Parkinson’s Disease'.

assistant: **Concept**

Parkinson's disease (PD), a highly incapacitating neurodegenerative condition of complex and multifactorial origins, remains incurable. As PD cases have skyrocketed by circa 160% since 1990, the burden on society grows heavier. The lack of reliable systems to test new therapeutics, allied with the limitations of current animal gold standard models, have eluded the development of safe and efficacious molecules to fight PD.ReMAP-PD aims at validating a novel 3Rs Microphysiological Alternative Platform for testing new therapeutics against Parkinson’s Disease based on a New Approach Methodology (NAM): a next-generation, human-based cellular disease model - fully aligning with the 3Rs principle of replacing, reducing and refining animal testing. Building on a novel microphysiological system, this PoC will deliver a scientifically robust and ethically compliant brain-on-chip platform that emulates key pathological features of PD. By validating this new platform for major in vivo PD cellular and molecular hallmarks, ReMAP-PD presents advantages over other NAMs for PD in terms of: ethical constrains related to cell source and accessibility; reagent costs; technical skills and standardization and user friendliness. With no current robust alternative to test new compounds against PD, ReMAP-PD will not only enhance NAMs translational value but also support a paradigm-shift in disease modelling, accelerating innovation while reducing reliance on animal experimentation.To unlock ReMAP-PD's innovation potential, we plan to conduct performance metric analysis using a well-characterized panel of drug compounds. Positive outcomes will support EU regulatory submission and attract stakeholder interest, while paving the way for ReMAP-PD IPR protection.


**Keywords:** Parkinson’s disease (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Tableau d'Observation Sociale des Centres d'Appel (Social Observation Table of Call Centres)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The objective is to draw up a social observation table of call centres, bringing out what characterises work in them, on the basis of a functional typology of such centres. It will be based on the problem area, which includes call centres, not only as players, but as exemplary" cases of on-going changes in the field of work and, consequently, industrial and social relations, which the latter establishes. Therefore, it is also appropriate to question the pertinence of analytical tools used and, through this original study, contribute to their renewal. It is a matter of facilitating player's understanding - and with their indispensable co-operation - of the issues and social consequences of the current tremendous increase in importance of information and communications technology in the productive process, of which call centres already seem to be one of the most outstanding achievements.Research on call centres will essentially focus on a quantitative approach. On the basis of an inventory of call centres in partnership countries, a representative sample will be established, which will define the scope of field work.The work will establish a typology of jobs in these centres on the basis of a detailed study of functions carried out, a study of work situations of a significant sample of operators, and an analysis of industrial and social relations in call centres."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Health On Line Monitoring for Electro-mechanical actuator Safety'.

assistant: **Objectives**

In the scope of the development of a more electrical aircraft, the project aims to develop a reliable tool for the health monitoring of electro-mechanical actuators (EMAs). The replacement of hydraulic systems with the implementation of EMAs on flight control actuation systems of both A/C and H/C can lead to many advantages but, since the mechanical jam of such a system has to be considered as a possible and high critical event, research activities have to pay attention to the compliance with the operational reliability and safety requirements. One of the most attractive and promising way to meet these requirements is the implementation of advanced health monitoring systems. Use of sensors for the detection of failures has been successfully proved by the research community, including Umbra, but the challenge of the HOLMES project is to rely on components that are basic on an EMA like electric motors, position sensors, motor commutation devices without additional sensing on the internal mechanical components (vibration, temperature, etc...). A promising parameter is the phase electric motor currents but other (e.g. voltage, speed of the motor and position of the actuator) will be evaluated. When this is the case, the reliability and safety of the EMA will be improved without any penalty in terms of weight and envelope. So, the strategy of the HOLMES project is to simplify the hardware measurement layout, moving complexity in the software and algorithm design. In this view, a mixed approach for FDI will be proposed. When a degradation (in a stochastic sense) of “on flight” measured variables will be evident with respect to the nominal values, a model-free FDI generates an alarm. This information will be integrated by the results of a spectral analysis of the measured sign
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Biological signal processing via multisite phosphorylation networks' under Horizon 2020.

assistant: **Concept**

Multisite phosphorylation of proteins is a powerful signal processing mechanism playing crucial roles in cell division and differentiation as well as in disease. Our goal in this application is to elucidate the molecular basis of this important mechanism. We recently demonstrated a novel phenomenon of multisite phosphorylation in cell cycle regulation. We showed that cyclin-dependent kinase (CDK)-dependent multisite phosphorylation of a crucial substrate is performed semiprocessively in the N-to-C terminal direction along the disordered protein. The process is controlled by key parameters including the distance between phosphorylation sites, the distribution of serines and threonines in sites, and the position of docking motifs. According to our model, linear patterns of phosphorylation networks along the disordered protein segments determine the net phosphorylation rate of the protein. This concept provides a new interpretation of CDK signal processing, and it can explain how the temporal order of cell cycle events is achieved. The goals of this study are: 1) We will seek proof of the model by rewiring the patterns of budding yeast Cdk1 multisite networks according to the rules we have identified, so to change the order of cell cycle events. Next, we will restore the order by alternative wiring of the same switches; 2) To apply the proposed model in the context of different kinases and complex substrate arrangements, we will study the Cdk1-dependent multisite phosphorylation of kinetochore components, to understand the phospho-regulation of kinetochore formation, microtubule attachment and error correction; 3) We will apply multisite phosphorylation to design circuits for synthetic biology. A toolbox of synthetic parts based on multisite phosphorylation would revolutio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The Common Core of European Administrative Law'.

assistant: **Objectives**

The European dimension of administrative law is the focus of a flurry of initiatives aiming to investigate similarities and differences, and to shape common legal scenarios. A codification of the administrative procedures of the EU has been envisaged by the European Parliament in its resolution of February 2013. A broader proposal of codification, including rule-making and contractual procedures, has been elaborated by ReNEUAL and has been discussed in a series of workshops in 2015.The issues that arise are both practical and theoretical:- it is important to understand whether the method traditionally followed by the European Court of Justice in order to identify the principles that are general and common to national legal systems, only applies when all those systems recognize such principles;- whether national systems of public law share the same idea of what an administrative procedure is is another question;whether the specific principles governing administrative procedures, such as the right to be heard and the duty to give reasons, are the same is still another question;- finally, if any commonality exists, the question that arises is whether it is limited to the level of general principles of law or it includes the which govern procedures.The research project is innovative on grounds of method, because: - it aims at ascertaining whether, and the extent to that, the well-established methodology developed under the ‘Common Core of European Private Law’ project can be applied to EU administrative law;- it permits to distinguish between ‘operative rules’, ‘descriptive formants’, and ‘meta-legal formants’;- it also allows to understand whether the specific nature of the interests recognized and protected by the rules of public law require legal methodologies that are d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Adopting Hospital Based Health Technology Assessment in EU'.

assistant: **Innovation**

The use of HTA as a part of the decision-making process at national, regional, and international levels has evolved considerably over the past 35 years. However, still an important number of good-value innovative HTs never reach clinical practice while, in many instances, others with no significant added value actually do. This situation can be effectively overcome by approaching HTA at hospital level, notably because hospitals are the main entry level for innovative HTs.To address these challenges, the AdHopHTA project aims at strengthening the use and impact of quality HTA results in hospital settings, making available pragmatic knowledge and tools to boost adoption of hospital based HTA initiatives. The project also aims at creating an adequate ecosystem where formal coordination among existing hospital based HTA initiatives and liaison with national and regional agencies will flourish. AdHopHTA focuses on hospital based HTA, an area not previously addressed by EUnetHTA, and in need of greater attention due to the considerable volume of resources that hospitals mobilise around investments in HTs.Through the 7 work packages, AdHopHTA will achieve the following 4 strategic objectives: 1) To perform a critical analysis of current formally established hospital based HTA initiatives; 2) To provide with a set of principles for best practice in hospital based HTA; 3) To advance a framework for setting a collaboration among current hospital based HTA initiatives and deployment to other interested EU hospitals; and, 4) To promote the collaboration and coordination of hospital HTA initiatives with HTA National/Regional organisations. The final results of AdhoptHTA will be: a) development of guiding principles on best practices for hospital based HTA; b) an accompanying toolkit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Engineered materials scale-up at industrial level for highest energy density ultracapacitors'.

assistant: **Concept**

The current proposal aims to analyze the feasibility of the Xerolutions S.L. business project, which is focus on mobile energy sources, in particular on the electrochemical energy storage systems, also known as super-capacitor (SC) or ultra-capacitor (UC). Electrochemical energy storage systems will constitute an essential element in the development of sustainable energy technologies, considering that the SCs can deliver energy quickly, can be recharged in seconds, and can withstand cold temperatures, shocks or vibrations. They also contain earth-abundant and nontoxic materials, so they are much environmentally friendly than today's batteries are. However, to take advantage of all opportunities that market offers, it is necessary that some technical capabilities of the SCs improve. While the currently available energy density is acceptable for applications such as emergency doors, memory backup and so on, limited energy density is widely perceived as the main impediment to growth of its sustainable energy applications. Therefore, much research and development has focussed on increasing SCs energy density at assumable price.Xerolutions designs and manufactures engineered carbon porous materials for SCs. Our Technology Platform controls the porosity structure adapting the size of pores for electrolytes ions dimensions to ensure high capacitance values and good charge propagations, especially at high loads. In this way Xerolutions materials achieve to increase the energy density of SCs while maintaining their high power capability, therefore the total device cost per unit of energy stored is reduced. Xerolutions has developed XER-HSA products range that is formed by open porosity carbons materials especially suitable to SCs which use different types of electrolytes. At pre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Heat and oxidization resistant titanium alloys applications' (HORTIA), addressing dissemination and exploitation.

assistant: **Impact**

According to aircraft market statistics, there is an increasing demand for new helicopters and NC, because European and American citizens are more and more sensitive towards environmental problems. Due to further hardening of environmental standards, A/C and Helicopter manufacturers will have to reduce the noise, CO_2 and Nox levels. Concerning the noise reduction, engine manufacturers have demonstrated high exhaust noise reduction by developing mixers and/or noise exhaust nozzles. But these studies reveal that the weight of these components will be a real challenge, related to the use of conventional technical approaches:(1) loss of one paying passenger over six for a twin engine helicopter;(2) cost increase of the noise damping exhausts due to additional devices compared to simple untreated exhaust nozzles;(3) thrust to weight ratio degradation inducing increased CO_2 emissions. Therefore, Research Centers and Industrials gathered in HORTIA programmed, creating a complementary consortium, to scan all the aspects of the final applications, from the identification of the available materials and associated properties to the performance validation including not only technical criteria but also costs, productibility and maintainability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Intersectional Politics of Antagonism in Peacebuilding' (IPAP) under Horizon 2020.

assistant: **Objectives**

The Colombian peace process signed in 2016 has shown that even when peace agreements include comprehensive measures to tackle structural inequalities seen as the root causes of the conflict, they may still be rejected by the very societal groups meant to benefit from such transformative provisions. IPAP addresses this dilemma by exploring how peacebuilding institutions can implement a peace agreement that is contested and work to include groups who have engaged in antagonistic actions against the peace accord. The research counters a tendency in the literature to treat resistance against peacebuilding as deviance or abnormality or as a mere manifestation of political and economic elites’ fear of losing power, by including the intersectional politics which explains these groups’ undermining or rejection of the peace process. The objectives of IPAP are: 1) to identify the fabric of antagonistic forces to peace and map their relations with political actors; 2) to examine the intersectional systems of power differentials through which antagonistic subject positions emerge and analyse how they transform into agonistic, i.e. constructively conflictive, relations with the work of peacebuilding institutions; 3) to explore possibilities for peacebuilding institutions to gain sustained legitimacy among the local population; 4) to identify ways in which peace institutions might engage with difference and create spaces where adversaries can engage in agonistic dialogue. To achieve these objectives, IPAP uses a feminist intersectional lens to peacebuilding, and an ethnographic fieldwork approach, to empirically study Colombia as a rich case of antagonism to peacebuilding. The innovative approach of IPAP consists in advancing the notion of antagonistic subject positions to peace to i