RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SALMONELLA IN PORK PRE-HARVEST AND HARVEST CONTROL OPTIONS BASED ON EPIDEMIOLOGIC, DIAGNOSTIC AND ECONOMIC RESEARCH' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Background :Animal-borne zoonoses constitute a serious public health problem. Of all meatborne infections, human cases of salmonellosis are considered the most important. Poultry and eggs seem to be the prime source of food-borne salmonellosis, and little information is known about the role of pork. Studies in some countries have shown that about 16% of human salmonellosis may be attributed to pork. The objective is :The overall objective is to establish the epidemiological basis, to develop the diagnostic tools and to evaluate options for the control of salmonella in pork at the pre-harvest and harvest levels Short description of the project : The following tasks will be carried out: 1) to determine and compare the prevalence and types of salmonella infections in pig herds in different EU regions, and to determine the risk factors for the spread of salmonella infections between and within herds; 2) to determine and compare the prevalence and serotypes of salmonella infections in pork samples from slaughterhouses in different EU regions and to identify critical control points for salmonella contamination; 3) to develop and evaluate improved biotechnological diagnostic tools for quantitative detection; and 4) to evaluate the epidemiologic, diagnostic and economic options for control of salmonella in pork, and to propose methodologies for surveillance and control programmes in the EU, based either on the detection of salmonella organisms or antibodies to salmonella. At the same time, the most promising diagnostic tools will be evaluated in samples from different EU regions and from controlled infection studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Public FLOOD Emergency and Awareness SERVice' (FLOOD-serv) under Horizon 2020.

assistant: **Objectives**

Floods are an increasingly acute problem. Floods endanger lives and cause human tragedy as well as heavy economic losses. In addition to economic and social damage, floods can have severe environmental consequences, for example when installations holding large quantities of toxic chemicals are inundated or wetland areas destroyed. Intense precipitation has become more frequent and more intense, growing manmade pressure has increased the magnitude of floods that result from any level of precipitation, and flawed decisions about the location of human infrastructure have increased the flood loss potential. Flooding cannot be wholly prevented. Flood risk increases with ongoing climate change. Risk reduction in large international basins can only be achieved through transnational, interdisciplinary and stakeholder oriented approaches within the framework of a joint transnational research project. The overall objective of FLOOD-serv is to develop and to provide a pro-active and personalised citizen-centric public service application that will enhance the involvement of the citizen and will harness the collaborative power of ICT networks (networks of people, of knowledge, of sensors) to raise awareness on flood risks and to enable collective risk mitigation solutions and response actions.  Other general objectives are:1. Empowering local communities to directly participate in the design of emergency services dealing with floods mitigation actions.2. Harness the power of new technologies, such as social media, and mobile technologies to increase the efficiency of public administrations in raising public awareness and education regarding floods risks, effects and impact.3. Encourage the development and implementation of long-term, cost-effective and environmentally sound mitigat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Targeting cancer vulnerabilities in acute leukemia'.

assistant: **Innovation**

Background and rationale: Adult acute leukemias pose a great challenge to cancer therapy, with only few advances made in 50 years. As these malignancies are commonly associated with multiple epigenetic aberrations, epigenetic factors represent attractive leukemia drug targets. Nevertheless, most epigenetic-targeting drugs have displayed limited clinical benefit and key leukemia drivers like MYC, ERG and MYB remained mostly undruggable. We have developed a new class of small molecule kinase inhibitors, termed “oncodestroyers” (ODs), single molecules combining supreme p53 activation with selective disruption of multiple leukemia-specific super-enhancers (SEs) that drive oncogenes and dependency/vulnerability factors. These inhibitors demonstrate an unprecedented therapeutic potency in mouse models of human leukemia and are entering now leukemia clinical trials. With this project we wish to study the principles of “oncodestruction”, mechanisms of drug action, immune system interface, and preempt drug resistance. Relevant knowledge may be applied to other cancer diseases, sharing vulnerabilities with leukemia. Major Goal: To expand the therapeutic potential of ODs in leukemia and pre-leukemia by studying their vulnerability basis, mechanisms of drug action and indicators of therapeutic response in individual patients. Research plan: 1) Expand the collection of small molecule kinase inhibitor ODs and develop OD-based PROTACs to gain an optimal spectrum of kinase targets with good therapeutic window in AML; 2) Elucidate the mechanisms of action and what distinguishes an OD, with emphasis on SE disruption, p53 activation and OD-immune-cooperation; 3) Explore the translational aspects of OD treatment by: identifying OD resistance and relapse mechanisms; study clonal evolution i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Accelerating Research Through Individualized Funding Intelligence' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Researchers are under ever increasing pressure to compete for research funding. More and more time is spent on writing lengthy proposals with dwindling success rates. IDfuse is a Dutch SME that wants to help researchers identify specialised, less well known funding opportunities. In 2016, IDfuse has launched impacter.eu, a successful online tool that runs automated analyses on drafted grant applications, allowing academic researchers to strengthen their grant proposals. IDfuse envisions to go a step further in its service by providing researchers with alternative funding opportunities based on the reviewed proposal and the scientific profile of the researcher, thereby accelerating research through individualized funding intelligence (ARTIFI). The envisioned product should essentially consist of a machine learning engine that is able to actively learn from interacting with the individual researcher. Moreover, in order to be able to present researchers with opportunities that go beyond what they would typically think of, IDfuse envisions that the engine should be able to expand the researcher profile with insights that can be extracted from open source research materials, including abstracts and open access scientific publications. In order to fully explore the development of such learning algorithm, expertise in the field of artificial intelligence and active machine learning is required. IDfuse currently does not have this expertise in its R&D team and it has not been able to recruit an individual with such expertise. This is mostly due to the low availability of suitable candidates and the high salary packages that larger companies are able to offer them. EC funding for an Innovation Associate will enable IDfuse to offer prospective candidates a competitive employment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Micro-Hydration of Atmospheric Molecular Clusters'.

assistant: **Objectives**

Modern computational chemistry methods are helpful tools for interpreting experimental and field measurements. The proposed HYDRO-CLUSTER project uses quantum-chemical calculations to provide molecular insight into the effect of humidity on molecular cluster formation in the atmosphere. These atmospheric clusters may grow in size and form aerosols, tiny particles dispersed in the air that hugely impact climate and human health. Water vapour is known to vary the particle formation rate. However, the presence of water molecules in the initial steps of new-particle formation (NPF) is not well understood, as very few theoretical studies on this topic have been published. On one side, hydrated molecular clusters become larger in size, and thus their collision with other molecules is more probable. On the other side, the cluster stability can be either lower or higher, complicating the fragmentation/evaporation of hydrated clusters. Current theoretical models can be several orders of magnitude wrong in predicting NPF rates as they do not account for the effect of water properly. In this project, configurational sampling of micro-hydrated acid-base clusters will be performed to reveal molecular insight into their thermodynamic stability. Machine-learning models for quantum systems will enhance both configurational sampling and molecular dynamics simulations, allowing us for the first time to reveal the role of water in cluster formation. Finally, we will model the effect of humidity on the atmospheric NPF and suggest a methodology for improving global climate models.


**Keywords:** Machine learning, quantum chemistry, micro-hydration, configurational sampling, new-particle formation, atmosphere
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Understanding the evolution of Active Galactic Nuclei' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

It is well established that the population of Active Galactic Nuclei (AGN), which are powered by accretion on supermassive black holes (SBH) at the centres of galaxies, has declined dramatically in the last 7 Gyrs of cosmic time (from z=1 to z=0). Elucidating the physical mechanism responsible for this rapid evolution remains a challenge for astronomy, despite over 35 years of investigations. It is the ambitious but realistic goal of this proposal to address this long-standing problem. A recent development that promises a breakthrough in the field has been the realisation that in order to understand active SBHs we need to study them in relation to their host galaxies. At high redshift (z~1) for example, there is currently a wealth of information on the nature of AGN hosts that provide important clues on the physical conditions under which accretion on SBHs occurs. Such studies have to be performed over a wide redshift baseline however, if we hope to get a handle on the physics behind AGN evolution. Unfortunately, although a huge amount of resources has been devoted to observations of the deep Universe, there is currently no systematic effort to complement them at low redshift. This proposal will bridge this gap by compiling the largest sample of X-ray selected AGN at z~0.1 to study the properties of their hosts, including their (i) star-formation history, (ii) stellar mass and (iii) large scale environment. A unique feature of the proposed program is that the AGN selection is almost identical to high redshift surveys, thereby allowing direct comparison of the samples. The proposed survey at z~0.1 will be combined with similar programs at z~1 to perform, for the first time, redshift dependent studies of the conditions under which AGN occur, thereby placing tight constrai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'S-nitrosylation mediated signalling during the response to different stresses:A proteomic-based approach for functional characterization of leaf peroxisome S-nitrosylatied proteins'.

assistant: **Concept**

Peroxisomes are organelles that have an essentially oxidative type of metabolism. In plant peroxisomes the presence of proteases and a set of antioxidative enzymes have been demonstrated. In addition, the presence of nitric oxide synthase suggests that they are a cellular source of NO and adds new cellular functions to peroxisomes related to oxygen and nitrogen reactive species as they have the capacity to generate and release into the cytosol important signal molecules. The study of the regulation of these molecules that could mediate the inter-organellar communication is an important emerging area in plant research, which can supply more information on peroxisomal contribution throughout plant development and in plant response to different stress condition.  Recent evidences indicate that in animal tissues NO regulates diverse biologic processes by directly modifying proteins. NO and RNS can oxidize, nitrate or nitrosylate proteins. S-nitrosylation refers to the binding of a NO group to a cysteine residue and it could play a central role in NO-mediated signalling. Accumulating data suggest that many proteins are S-nitrosylated by NO indicating that S-nitrosylation may be a ubiquitous post-translational modification regulating protein function. It has been shown that S-nitrosylation plays a comparable role to phosphorylation in animal cell biology and signal transduction. However, very little is known about the dimension of the physiological function of S-nitrosylation in plants. The aim of the proposed project is to assess the occurrence of S-nitrosylation in plant peroxisomes, with the identification and functional characterization of the NO-target proteins. Additionally, we propose the study of the changes in the pattern of S-nitrosylated proteins during different s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Visual Notify - Improving Deaf People's Life' (Visualfy).

assistant: **Innovation**

Visualfy is developing a suite of smartphone Apps, through which it enables people with hearing deficiencies to more seamlessly interact with their environment. Visualfy’s current minimum viable product (MVP) allows Smartphone events, such as incoming (Video)-Calls, E-mail, and Whatsapp, to be linked to different screen-flash and vibration patterns, to notify a deaf person. Therewith, the MVP solves one of several key problems. Validation of the MVP is currently under way, with early positive responses reflected through currently 5000 customers, with around 200 new customers joining per week.It is clear that deafness can cause all kind of problems in daily life, like not being able to note alarm sounds, or simply problems with inter human communication. It is less well known that people with pre-lingual deafness (deafness before the acquisition of language) have difficulties to develop a spoken language and even to read and write, as these capabilities are tightly intervened with the formation of language (think of the spoken word forming in your brain while reading). According to the World Health Organization, partial hearing loss affects about 360 million people worldwide, 0.1% being pre-lingual. Considering at the same time a dramatically growing Smartphone penetration, even in poorer societies, establishes a growing market environment.Initial sales of the MVP are qualitatively validating one key customer problem, and the market seems ripe for disruptive innovation, allowing the introduction of Visualfy’s Smart Space Concepts to “Improve Deaf People’s Life”.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Enabling Multifunctional Plasmonics on Hybrid Artificial Scale-Integrated Systems' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Optical isolator, or optical diode, is a device, which allows the transmission of light in only one direction. They are used in fibre optic communication to prevent back reflections and improve signal-to-noise ratio.  The development of on-chip optical communications requires downscaling of optical components, e.g replacing optical fibres with nanoscale waveguides. The miniaturization of optical isolators is therefore a key step towards integrated photonic circuits. We approach this challenge by taking advantage of surface plasmon resonances that can squeeze light down to nanoscale dimensions. We combine plasmonic waveguides with ferroelectric and -magnetic materials that, in turn, break the space-inversion and time reversal symmetries to create non-reciprocal conditions for light propagation. The ferroelectric and magnetic materials provide us with an additional interesting advantage: their optical properties can be adjusted by applying external electric and magnetic fields, enabling active control over light in nanoscale. The proposed research project brings together the candidate’s expertise in plasmonics and the hosting group’s established knowledge in oxide thin films. This creates excellent conditions for training through research and knowledge transfer. We envision two significant outcomes: (i) demonstration of a proof-of-concept plasmonic isolator based on symmetry considerations and (ii) assessing the viability of using active oxide materials as tools to control plasmon propagation with external fields. The H2020 Innovation Union initiative strives to drive economic growth in the EU by innovation. In line with this strategy, we recognize that EMPHASIS offers ample potential for technological applications and include strategies to ensure that the potential can b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Structural characterization of filamentous bacteriophage viruses by magic-angle spinning solid-state NMR spectroscopy' under Seventh Framework.

assistant: **Concept**

Filamentous bacteriophages comprise a family of viruses that share a similar virion structure and life cycle. The virion is composed of a circular ssDNA wrapped by thousands of similar copies of a major coat protein and several different minor coat proteins in both ends. Due to the mass (tens of MegaDaltons) and dimensions (~7 nm in diameter, 600 – 2000 nm in length) of filamentous phages, structural models have been obtained primarily from fiber diffraction, and from static solid state NMR of aligned concentrated solutions. Yet, these models are incomplete, and vary even within individual virions. Also, some key questions regarding DNA structure, subunit-DNA interactions, microscopic polymorphism, and more, remain unclear or are in debate. Magic-angle spinning solid state NMR (MAS SSNMR) has been shown recently to be a complementary and successful method for studying the structure and dynamics of biological macromolecules. Examples are membrane proteins, protein aggregates and fibrils, and recently, the Pf1 filamentous phage. Also, sample preparation for MAS SSNMR is more flexible, and measurements can be performed in conditions, which are either biologically relevant, or important for their biophysical characterization. The goal of the proposed project is to structurally characterize and compare the three key phages fd, Ike, and Pf3, using MAS SSNMR as a principal spectroscopic tool. These phages were chosen, since they represent different structural properties of such virions. We anticipate that our proposed studies will resolve some of the key questions regarding the structural assembly of filamentous phages, and enhance our understanding on the possible ways in which these phages assemble at their host bacteria. Our results will also provide suitable model systems