RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Synthesis of c-linked glycosylated amino acids' (1994-1998).

assistant: **Innovation**

Research objectives and content Glycopeptides play an important role in biology. For example, oxygen linked glycopeptides are believed to have a role in the resistance of the proteins to hydrolysis, and there has been some interest in the effects of glycosylation on the activity, stability and metabolism of glycosylated peptide drugs. The main synthetic (and operational) problem is that the glycosidic linkage is susceptible to both chemical and enzymatic cleavage, which limits the methods for the synthesis and the applicability of such compounds as drugs. To tackle the above mentioned problems a method for the synthesis of C-linked analogues of glycosylated amino acids (specifically of serine and threonine) will be developed and generalised. A number of selected key target compounds will be synthesised and characterised. The attention is drawn especially on the synthesis of difluoromethylene analogues, due to the well known superiority of the difluoromethylene group as an oxygen mimic. In addition, some new amino acid derived zinc reagents will be developed, characterised and applied for synthesis. Training content (objective, benefit and expected impact) The main benefit of this training is the collection of practical experience on a variety of different types of organic reactions. Furthermore, the project trains in asymmetric synthesis as well as in carbohydrate and peptide chemistry. Links with industry / industrial relevance (22) The project has industrial relevance, since it is concerned with the development of a general approach to the synthesis of analogues of glycopeptides which are of significant biological interest. The host research group has an on-going collaboration with Roche in this general area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Additive Manufacturing of Molecular-Level-Engineered SiCN Ceramic Modified with Carbon Nanofibers/Transition Metal Carbides towards Next-Generation Structural Electromagnetic Metamaterials' (EMAMs) under Horizon Europe.

assistant: **Objectives**

Ceramic-based high-temperature structural electromagnetic absorption materials (EMAMs) is playing an increasingly important role in combating the EM pollution. However, ceramic-based EMAMs always suffer from poor mechanical strength due to the intrinsic high brittleness, and unsatisfactory EM performance limited by the material characteristic as well as the monotonous loss mechanism of absorbents. In this project, advanced SiCN matrix modified with one dimensional (1D) carbon nanofibers/2D transition metal carbides (e.g., TiC, VC and Mo2C) (CNFs/TMCs-SiCN) ceramic-based structural EM metamaterials will be innovatively developed by combining molecular-level-engineered polymer derived ceramic (PDC) and Additive Manufacturing (AM) techniques. Novel 2D TiC, VC and Mo2C nano-absorbents/reinforcements will be developed via a precursor-derived method. Outstanding EM performance is expected to be realized by the establishment of multi-loss mechanisms (i.e., interface, defect-induced and dipole polarization loss, and conductive loss) via nano/microstructure engineering of CNFs/TMC absorbents, and realization of novel meta-structures using AM. Improved mechanical strength will be achieved by strengthening of the SiCN matrix by CNFs/TMCs. The main idea of the present proposal is to merge material type and nano/microstructure innovation of absorbents/reinforcements as well as meta-structure innovation of materials to innovatively develop the CNFs/TMCs-SiCN structural EM metamaterials as the next generation high-temperature structural EMAMs. The general relationship between (nano- and micro-)structure, macro-structure (by design) and loss mechanisms, EM and mechanical properties will be revealed. This project will pave new avenue for the development of next generation EMAMs.


**Key
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'VAriable ResolutIon Algorithms for macroMOLecular Simulation' (VARIAMOLS) under Horizon 2020.

assistant: **Objectives**

Within the broad spectrum of biological soft matter systems, large proteins and protein assemblies occupy a central role. These molecules are extremely versatile: they can catalyze chemical reactions, transport atoms and molecules across the cellular membrane, bind to foreign bodies to be destroyed, or combine into large molecular machines that perform a variety of different tasks. One of the most prominent problems in the computational study of these macromolecules is that the cost of using accurate atomistic models dramatically increases with system size. Simplified, coarse-grained representations offer an elegant and effective alternative to high-resolution models, and enable the simulation of large systems over extended time scales; the other side of the coin, however, is that the missing chemical detail often represents an insurmountable limitation to the realistic reproduction of the properties of interest. The main goal of the VARIAMOLS project is to develop and apply novel computer-aided methods for the study of large molecular assemblies and their dynamics, thus bridging the existing gap between computational cost and chemical accuracy. Specifically, the research will unfold along two intertwined lines: 1) the development of non-uniform resolution models of the system, which optimize the balance between detail and efficiency; and 2) the study of dynamics-mediated properties of protein assemblies. The working philosophy of VARIAMOLS has two complementary and strictly interconnected aspects: on the one hand, the theoretical and algorithmic advancement of the methods currently employed to represent and simulate biomolecules; on the other hand, the systematic application of the developed methods to real-life case studies of great relevance for medical science and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Harnessing Carboxylic Acids via ABC – Asymmetric Boronic acid-based Catalysis' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Developing new methods to functionalize molecules controlling their stereochemistry is of outmost important in almost any area of chemistry. However, factors such as costs, efficiency, sustainability and waste production are a major concern. As the pharmaceutical industry is increasingly aware of the importance of and greater clinical success in creating biomolecules with 3-D architectures there is a strong impetus to try to develop new efficient and sustainable asymmetric methods. The impact of organocatalysis (the use of small organic molecules to promote asymmetric transformations) has been immense across many aspect of society spanning from the synthesis of pharmaceutical compounds to agrochemicals and materials. However, whilst useful for the activation of compounds such as aldehydes and ketone, this concept cannot be used for the functionalization of carboxylic acids. This limits the development of new and efficient methods because carboxylic acids frequently represent the starting material as well as the final product of many synthetic sequences. This proposal seeks to explore fundamentally new ideas based around rationally designed boron transformations aimed at the development of novel approaches towards asymmetric, transition metal-free functionalization of carboxylic acids. The proposed approach relies on the activation of carboxylic acids by the addition of chiral boronic acids catalysts to generate chiral mono-acyl boronate intermediates. Subsequent addition of a nucleophile (or a diene) would results in highly valued and polyfunctional non-racemic carboxylic acids, amides and thioesters with water as the stoichiometric waste. Preliminary DFT calculations suggest that the asymmetric induction is viable. This proposal is aimed at the career development of ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Modulating motor output in the mammalian spinal cord'.

assistant: **Objectives**

The executive component of movement – the task of determining which muscles to activate, how intensely, and for how long – depends on neural circuits located in the spinal cord. At the core of these circuits are local interneurons (INTs) that regulate the pattern and frequency of motor neuron (MN) firing. Spinal motor activity is shaped by a combination of amino acid mediated excitation and inhibition, but the amplitude of motor bursts depends in large part on modulatory systems. I have identified the source and output of a spinal pre-motor modulatory circuit mediated by muscarinic cholinergic signaling. The transcription factor Pitx2 defines a small set of INTs that further fractionates into V0C cholinergic and V0G glutamatergic subsets. My initial findings have revealed that MNs receive prominent inputs from V0C neurons and that genetic inactivation of the output of V0C neurons impairs a locomotor task-dependent increase in the activation of specific limb muscles. These observations have provided initial information about the function of this intrinsic cholinergic modulatory system, but they leave many unresolved questions about the organization and function of the circuit.-Does V0C innervation pattern respect antagonist relationships in motor pool activity?-What are the inputs that control the function of V0C neurons?-Do V0C neurons also modulate INT output?-Does the limited impairment of motor modulation after disconnecting V0C neurons result from functional adaptation?-Do V0C and V0G neurons cooperate as dual elements in a transcriptionally defined “modulatory operon” for motor control?I will use a combination of mouse genetics, anatomy, physiology and behavior to address these questions. Inactivation or ectopic activation of V0C and V0G neurons during locomotor be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New Clean Energy Communities in a Changing European Energy System (NEWCOMERS)' (NEWCOMERS).

assistant: **Innovation**

The European energy market is rapidly changing under the influence of three megatrends that currently drive the transformation of energy sectors worldwide: decarbonization, decentralization and digitalization. These megatrends have stimulated several technical and social innovations in the energy sector, which offer alternatives to the traditional business model of large centralized energy utilities and have the potential to further the goals of the Energy Union. One such example of social innovation in the energy sector are new forms of local energy communities that generate, store and use energy in a collaborative way and hence allow consumers to get involved in the production and storage of energy (“prosumage”) at the local level. New clean energy communities in a changing European energy system (NEWCOMERS) are often democratic and participatory in nature and at the same time characterized by unconventional alliances of actors, the use of innovative and smart technologies and new forms of value creation for their members and society. The NEWCOMERS project aims to investigate which regulatory, institutional and social conditions, at the national and local level, are favorable for the emergence and operation of  new clean energy communities. Furthermore, NEWCOMERS will explore how these new clean energy communities meet their members’(i.e. citizens’ and consumers’) needs better than more traditional energy services business models and whether they have the potential to increase the affordability of energy, their members’ energy literacy and efficiency in the use of energy, as well as their members’ and society’s support for the clean energy transition. The ultimate goal of the NEWCOMERS project is to identify the types of clean energy communities that perform best alon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Complex structural and multifunctional Parts from enhanced Wood-based Composites - eWPC' (BIOSTRUCT).

assistant: **Innovation**

Despite a lot of research activities carried out in the field of Wood Plastic Compounds there is still a certain lack of interest in the commercial market for this new class of materials. BioStruct will help to overcome these barriers in the market success by the development of the next material generation, so-called enhanced Wood Plastic Composites eWPC, avoiding the most important drawbacks in conventional Wood Plastic Composite technology, like: low impact strength and brittleness, inconsistent material properties due to different fibre qualities, low temperature resistance, strong smell and high emission levels and instability in humid conditions. Nowadays polymers reinforced with natural fibres (mainly wood fibres) are predominantly based on petrochemical polymers, so called WPC (wood plastic compounds). They are mostly used in low-cost applications and the wood fibres are used as low-cost fillers. Recent R&D (see IP-SMEs Biocomp) introduced a new family of materials, so- called bio-composites, that replace petro-based polymers based on bio-polymers as matrix materials. These materials show mechanical and thermal properties that meet industrial requirements for some standard polymer applications, where mechanical strength is not a key issue, but they fulfil the environmental and sustainability concerns. Nevertheless the price of these bio-composites is in many cases too high for these standard applications, like housing or packaging trays. BioStruct will develop eWPC, the next generation of advanced wood-based composites that can be used in demanding, high-value technical applications. In its intelligent combination of innovative development approaches BioStruct will develop cost-efficient materials and processes for eWPC that will clear the way for these resource
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Catalytic oxidation of industrially important organic substrates using molecular oxygen and transition-metal oxo complexes' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content Over recent years the use of transition-metal oxo complexes to effect catalytic regioselective homogeneous oxidations has become increasingly important. Recently in the group of Osborn the catalytic oxidation of primary alcohols, under one atmosphere of dioxygen, to aldehydes has been achieved selectively and quantitatively by a transition-metal oxo complex with a second metal complex capable of activating dioxygen. This approach can be expanded to other oxidation processes such as epoxidation and dihydroxylation of alkenes. This project seeks to establish in detail the potential of this approach by evaluating: (i) the range and limitations of their use (e.g. tolerance or oxidation of other functional groups) (ii) the development of the most efficient catalyst combinations (iii) effect of ancillary ligands (iv) effect of dioxygen activating complex (v) the nature of the intermediates involved and the mechanism of these reactions Training content (objective, benefit and expected impact) This study seeks to increase the knowledge of the applicant, by the use of new synthetic and spectroscopic techniques and to apply pure academic research to an industrial problem using state-of-the-art catalytic methods. Current homogeneous oxidations used in industry are extremely inefficient and wasteful. Early indications are that the potential applications and possible economic advantages of this proposal are enormous. Links with industry / industrial relevance (22) This research will be of importance to academic chemists and the process and speciality chemical industries. The regioselective and qualitative yields anticipated with this system may revolutionise industrial homogeneous oxidations of organic substrates. Since the project is interesting from
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mitochondrial Dynamics and Local Protein Synthesis in Dendrites' (NEUROMITO).

assistant: **Concept**

Neurons are specialized cells with polarized morphology. Efficient function dictates that the molecular events crucial for synaptic communication are not centralized at the cell body but distributed to individual subcellular compartments - dendrites, dendritic spines, axons, presynaptic terminals. Local protein synthesis in dendrites is one such mechanism that plays a significant role in synaptic plasticity and memory. However, little is known on how the high-energy demands of local protein synthesis are met at dendrites and spines.Mitochondria, the 'energy houses' of cells, are found in great abundance in neurons. Mitochondria are associated with: nuclear-encoded messenger RNAs for local translation of great majority of mitochondrial proteins; non-coding RNAs for translational regulation of its protein abundance. To meet the local energy demands of protein synthesis, it is likely that mitochondria compartmentalize at dendritic regions and undergo dynamic changes in their proteome and transcriptome. My research project aims at elucidating the dynamics of mitochondria during high-energy demands of local protein synthesis. I will be performing experiments to examine mitochondrial compartmentalization in dendrites. Since simple fluorescence time-lapse imaging is not sensitive enough to visualize mitochondrial dynamics, I will use state-of-the-art imaging tools available in Dr. Erin Schuman’s lab for my experiments. I will also exploit the special neuron culture platforms, Microfluidic chambers, co-invented in the Schuman lab, for this purpose. In addition, I will be performing proteomic and transcriptomic analysis of mitochondria isolated from somata and neurites. To this end, I will use the shared protein mass spectometry facility of the Max Planck Institute for Brain Res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a non-invassive breath test for early diagnosis of tropical diseases' (TROPSENSE).

assistant: **Concept**

This project aims at demonstrating the feasibility of a non-invasive, safe and patient-friendly methodology for on-site rapid diagnosis of tropical diseases. The proposed approach is based on breath samples analyses, which are easy to obtain and present no discomfort or risk for patients health. In this study will be enrolled patients with three different types of neglected tropical diseases (Hydatidosis, Leishmaniasis and Dengue) from different geographical locations (Europe, South America and Maghreb). Breath sampling will follow a standardised procedure. Analytical chemistry methods will be employed for the identification of the breath volatile biomarkers of these diseases. A pool of potential nanomaterials with high affinity towards the identified VOCs will be selected (e.g., gold nanoparticles, carbon nanotubes and semiconducting nanowires, either pristine or functionalised with selected hydrophobic organic molecules and/or bio-molecules). For maximising the possibility of success of our methodology, we will investigate the synergic effect of different advanced and complementary chemical sensing techniques: Mid-Infrared Quantum Cascade Laser spectroscopy and different types of Chemical Gas Sensors devices. These techniques are particularly attractive, since they can be miniaturised and are suitable for building on-site portable systems. Advanced pattern recognition algorithms will be employed for building discriminative models for the identification of the fingerprints of the different tropical diseases studied, and multisensors data fusion will be then applied for obtaining enhanced resulyts. A point of care prototype will be proposed on the basis of the results obtained and validated on-site.