RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Experimental investigation of the properties and statistics of quantum levels in nanoscale semiconductor devices' (1994-1998).

assistant: **Concept**

Research objectives and content The aim of the project is to investigate experimentally, using electrical transport measurements at low temperatures, the energy levels of small quantum systems fabricated in the solid state. The reproducible pseudorandom structure in the conductance as a function of bias, gate voltages and magnetic field will be measured in unprecedented detail in order to investigate the statistics and other properties of the energy levels for comparison with recent theoretical predictions in this extremely topical area of physics. Experiments on three types of device are proposed. The first is a small region of two-dimensional eleoctron gas (2DEG) connected by metallic leads, which will be used to investigate levels in a 2D metal and in a quantum Hall conductor. The second is a ballistic cavity, where quantum chaos theory predicts intriguing relationships between the level statistics and the presence of nonchaotic classical electron orbits. The third is a single carbon nanoutube, which has very recently been found to exhibit one-dimensional relativistic dispersion and a large level spacing, presenting the exciting prospect of studying the properties of individual levels corresponding to a very different type of quasiparticle from those found in normal metals. Training content (objective,benefit and expected impact) The applicant expects to learn and develop new techniques of device fabrication and measurement for use in futur research, and to improve his understanding of the subject by collaborating directly with eminent theorists. Further the applicant expects to pass on his particular skills, including those of measuring fluctuations in low temperature transport.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Identification and analysis of novel proteins required for Wingless secretion.' in the context of a Seventh Framework call.

assistant: **Objectives**

Wnts are secreted signaling proteins that control multiple developmental processes and have been implicated in several human cancers. All Wnt proteins, including Wingless, a Drosophila member of the Wnt family, associate with cell membranes. This membrane-association is a result of posttranslational acylation and strong affinity for heparin sulfate proteoglycans. Despite its association with cell membranes, Wingless acts over several cell diameters in a number of developmental contexts. It has been suggested that transport is achieved by liprotein particles but functional evidence is incomplete and nothing is known on how Wg is packaged into such particles. During my postdoctoral research I will study the secretion and release of Wingless by expressing cells. Specifically, I will define the pathway of Wingless secretion and its site of export from the cell. Second, I will identify novel proteins required for the secretion and release of functional Wingless protein. This will could uncover specialized secretory pathway and will provide a framework to understand how Wingless functions with tissues. Understanding the pathways that regulate short and long range signaling by Wnts is likely to have an impact both in basic sciences (e.g. about the cell biology of lipid modified secreted proteins) and in medicine (providing potential targets for drug that would modulate this important signaling pathway).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'NOVEL CIRCULAR RESIN DEVELOPMENT FOR COMPOSITE STRUCTURES IN WIND ENERGY APPLICATIONS' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

The goal of ECORES WIND is to develop novel circular resin material systems tailored for composite structures in wind energy applications. These materials are intended to enhance circularity and minimize the environmental footprint of entire wind energy systems throughout their life cycles. The project seeks to tackle the ecological impact attributed to conventional resin systems used in wind turbine blades. It aims to explore alternative choices that facilitate enhanced circularity, prolonged lifespan, and efficient decommissioning.ECORES WIND will evaluate the ecological advantages inherent in each resin system it develops. By comparing them to state-of-the art materials in various categories, the project aims to ascertain improvements in recyclability, circularity, and the potential of bio-based products to achieve a more sustainable future.The introduction of circular resins in coordination with the use of advanced disassembly strategies will make the decommissioning of wind blades and reutilisation of materials for other applications possible and cost effective.


**Keywords:** circular resin material, reversible adhesives, modelling, infusion process
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Integrated emerging approaches for joint protection and restoration of Natural Lakes in the spirit of European life heritage support (ProCleanLakes)' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

ProCleanLakes targets to combat the combined impact of various disruptive factors that generate continuous pressure on the lake's ecosystem status and facilitate the accumulation of emerging, non-regulated, chemical contaminants and nutrient enrichment. The project will design and demonstrate the feasibility of integrated nature-based emerging approaches for joint protection and restoration of European Natural Lakes (ENL) and their biodiversity, considering scenarios which imply the presence of various pressures that affect the aquatic ecosystems' status. The holistic transdisciplinary approaches that are to be used in the project, based on the synergic effect of the economic-environment-social nexus, targets to support the improvement of ENL ecological and chemical status in association with major EU instruments, sustainable development goals and policies related to freshwater ecosystems. The project engages multiple sites affected by the presence of various pressures and stressors, that will be the subjects for the demonstration of integrated protection and restoration solutions efficiency. A replication roadmap powered by the necessity of assuring upscaling and universality of the optimal integrated solutions (IS) will be developed to prove the replicability. An IS support platform which merges a business accelerator with an adaptive artificial intelligence (AI) solution for empowering citizen science related to lakes protection and restoration will assure the collaboration between the municipalities and citizens and will offer capacity-building and encourage co-development and co-design towards natural lakes protection and restoration. Tools such as mobile decision support platforms, serious games for digital readiness, e-learning and augmented-based modules for rei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project '“Gene Editing”Molecular Design Fire-retardant Electrolyte for Long-term Stability of LIBs (GENE4LIB)'.

assistant: **Objectives**

Lithium-ion batteries (LIBs) have been widely used in Europe across consumer electronics, electric vehicles and energy storage power stations due to high energy-density, relatively long lifespan, and low self-discharge rates. However, the fire risk of the LIBs is high, and the lifetime is seriously attenuated under abuse conditions. Therefore, the overarching aim of this ambitious yet achievable project (GENE4LIB) is to develop next generation safe and long-lasting LIBs through designing high performance ionic liquids (ILs) based flame-retardant electrolyte (ILFRE). The new ideas in GENE4LIB to achieve this goal include: i) Developing gene editing-like ILFRE which can increase the lifetime of LIBs and decrease fire hazard of LIBs; ii) Clarifying the effect of composition and structure of gene editing-like ILFRE on GENE4LIB electrolyte performances, electrochemical properties and fire safety performances of LIBs; iii) Gaining in-depth understanding of underlying mechanism of gene editing-like ILFRE in extending the lifespan and inhibiting fire of LIBs. ILs can provide flame retardancy through both gas-phase and solid-phase mechanisms. In the gas phase, ILs release free radicals generated by flame-retardant elements (such as P, N, and B), which capture active free radicals during combustion, thereby interrupting the chain reaction of combustion. In the solid phase, ILs promote the formation of a stable carbon layer on polymers, providing thermal insulation and oxygen barrier properties, thereby inhibiting combustion. Moreover, ILs functional groups will influence free solvents of first solvated sheath to form weak solvation, reducing desolvation energy. It is crucial for enhancing battery performance, particularly at low temperatures and high rates owing to improved ionic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Redefining Virtual Reality Therapy for Anxiety Disorders' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Social anxiety disorder (SAD) – the most common type of anxiety disorders – has severe emotional, financial and social consequences for patients, their families and their social network. Affecting about 7% of Europeans at some point in their life, SAD produces substantial societal cost due to long lasting treatments and extensive periods of reduced working capacity. To address this important problem, the project will establish an innovative system for treating SAD by exploiting the proven therapeutic potential of advanced Virtual Reality (VR) technology.SAD is predominantly treated with cognitive behavioural therapy, in which patients are repeatedly exposed to fear-provoking, social situations. However, patients often have to wait very long before treatment becomes available, exposure is rarely applied with the necessary intensity due to resource limitations, and objective measurement of treatment efficacy and dynamic adjustment of therapeutic scenarios is hardly possible. These problems can be overcome with VR based, controlled exposure to virtual renditions of fear provoking situations, which has been shown to surpass traditional therapies in terms of treatment efficacy, patient acceptance, and economic efficiency.Given that advanced VR technology has become very affordable, a widespread application of VR for the treatment of SAD is now within reach. The proposed project will fuse the applicant’s extensive VR expertise with established principles for VR based therapy to create an innovative system for the treatment of SAD. This system will, for the first time, combine interactive 3D environments with external physiological measures (e.g eye tracking data) and real-time data analyses techniques to provide a precise, flexible and time and cost-efficient therapeutic appr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Replication and post-replication signalling pathways Regulating R-loop-associated Telomere instability in human cells' under Horizon 2020.

assistant: **Concept**

Telomere stability is essential to prevent tumorigenesis and cellular senescence in human cells. Telomeres are transcribed into TERRAs, which has the ability to form R-loops with the DNA template. It is known that R-loops can hamper replication fork progression leading to hyperrecombination and genome instability. Indeed, R-loops are accumulated in telomeres of cancer cells that use the Alternative Lengthening of Telomere (ALT) maintenance mechanism to gain immortalisation and in ICF syndrome cells, associated with telomere shortening and senescence.The mammalian ATR-mediated replication stress signalling pathway and the RAD18-UBE2B ubiquitin-ligase complex involved in post-replication repair have been recently discovered as mains regulators of R-loop accumulation, suggested to act via different mechanisms. Interestingly, both pathways affect telomeres of ALT cells, where R-loops have been proposed as drivers of ALT recombination. Whether or not replication and post-replication signalling pathways have a differential role in telomeric R-loop control is not known, but it would be of key relevance to understand the role of R-loops in telomere dynamics both in normal and cancer cells. With this aim, we will investigate the molecular mechanisms that control pathological R-loop modulation at human telomeres by focussing into their accumulation during and after DNA replication and their regulation by replication and post-replication DNA damage responses. By developing new systems that allow a precise temporal control of R-loop levels and innovative single molecular approaches to detect R-loops at the replication fork, plus the use of and unbiased proteomics analysis of isolated chromatin from telomeres, I will identify new key factors and molecular mechanisms controlling telo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Future storage systems for the energy transition:  Polymer-based redox-flow batteries' (FutureBAT).

assistant: **Concept**

The efficient storage of electric energy represents a major challenge for a successful energy transition, enabling the utilization of fluctuating renewable resources also as base load. Redox-flow-batteries (RFBs) are the only type of battery where intrinsically power and capacity can be varied independently from each other, making this type of battery perfectly suited for scalable stationary applications. RFBs based on aqueous electrolytes with organic / polymer active materials have the potential to be suitable alternatives for commercial metal-based RFBs, with low CO2 footprint perfectly fitting to the goals of the EU Green Deal. In particular, polymer-based RFB systems enable the use of cost-efficient dialysis membranes together with pH neutral table salt solutions as electrolytes. Nevertheless, systems still reveal restrictions in terms of capacity, lifetime and temperature-stability.FutureBAT targets a breakthrough in the development of novel organic active materials for RFBs, by combining the search for new active entities with the improvement of current polymeric materials on the molecular level, by this providing new functions / properties. The key question will be how far polymeric electrolytes can be tuned by adjusting the molecular structure. Advanced polymer structures (incl. (hyper-) branched structures) and colloidal systems (with varied morphologies) as well as novel hybrid organic systems will provide access to hitherto unknown properties, e.g., new photo-rechargeable RFBs or RFBs having all charged species within one single tank. Furthermore, new sensor systems (SOC and SOH) will be applied, which also will form the basis for novel 3D-printed lab cells for (high-throughput) screening.As the outcome, pioneering breakthroughs in the field of polymer-based
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Epithelial cells in inflammation' (EPINFLAM) under Seventh Framework.

assistant: **Objectives**

The cross talk between the host and the microbiota is believed to be the major determinant of health and disease in the gastrointestinal tract. Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the intestine with unclear aetiology. Deregulation of the cross talk between the intestinal microbiota and the host immune system is considered a main factor contributing to IBD. Genomic studies revealed associations of NOD2 and of genes regulating autophagy and ER stress with an increased risk for IBD. Mutations in these pathways compromise Paneth cell dependent epithelial antibacterial defences causing alterations in the intestinal microbiota, termed dysbiosis. However, mutations in NOD2 or autophagy genes are not sufficient to cause intestinal inflammation in humans or in mice, suggesting that dysbiosis by itself cannot cause inflammation but additional, as yet unidentified, factors are required to precipitate the pathogenesis of IBD in genetically susceptible individuals. Mouse model studies revealed that epithelial specific mutations sensitizing intestinal epithelial cells to apoptosis or necroptosis triggered spontaneous intestinal pathologies with many features of human IBD, including loss of Paneth cells, impaired epithelial antimicrobial defences and chronic intestinal inflammation. We hypothesize that pathways controlling programmed cell death critically contribute to the pathogenesis of IBD by acting on Paneth cells to regulate epithelial antibacterial defences and simultaneously regulating intestinal epithelial cell survival and the integrity of the epithelial barrier. The aims of this research proposal are: a) to dissect the pathways regulating Paneth cell death and the development of dysbiosis in the gut, and b) to elucidate the additional gen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced Magnetic nanoparticles deliver smart Processes and Products for Life' (2007-2013).

assistant: **Concept**

Biotechnologically derived substances for large scale feed, food and pharma applications represent one of the most important sources of new products due to their precisely controlled structural and functional properties, potential for economic and responsible production and overall broad benefits to society through biocompatibility and sustainability. The costs of producing biomaterials are in many cases dominated by separation processes, which can constitute 80% of the total cost of production. Using smart magnetic adsorbent particles to selectively separate the target product out of a complex product mixture like the fermentation broth or bio-feed stock can drastically reduce costs. By using magnetic separation and extraction technologies to separate the magnetic carrier particles, novel processing ways emerge. The main objective of the MagPro²Life project is to scale-up innovative nanotechnology based processes defined in the previous NanoBioMag Project, funded by the EU under the FP6 programme (NMP3-CT-2005-013469), to pilot-line-scale and demonstrate those for bio, food and pharma applications. Link to market needs is represented by a preliminary product selection of natural soy based nutraceuticals or pharmaceuticals like Bowman-Birk Inhibitor (BBI), a proteases inhibitor for MS-treatment, and Lunasin which is in discussion to have anti-carcinogenic properties as well as recombinant proteins and nucleic acids (Fragment-Antibody-Binding and Phytase). The Consortium is driven by the potential the magnetic separation technology has for improving the value-chain in industrial production for emerging biotech, food and pharma markets.