RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ab initio pathway to deformed nuclei' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Nuclear physics is one of the main drivers for extending our current understanding of Nature, its fundamental forces and the organization of compound systems on subatomic scales. The description of atomic nuclei and nuclear matter connects microscopic systems to astrophysics and the origin of elements, bridging orders of magnitudes in energy scales. A precise understanding of the rich nuclear phenomenology and their emergence from the interaction between neutrons and protons impacts various facets of contemporary physics. Despite tremendous progress over the past decades a fully controlled description of nuclei throughout the entire nuclear chart is still lacking. In particular many experimentally relevant nuclei reveal exotic shapes and strong deformation where nuclear physicists still rely on the use of phenomenological approaches based on uncontrolled approximations with limited predictive power beyond the regions where they have been adjusted.In my project I will develop new technologies to target deformed nuclei using nuclear interactions derived from chiral effective field theory and study the impact of interaction models on the predicted nuclear shapes. Combined with a uncertainty quantification of many-body observables this allows for unprecedented predictions of nuclei far away from shell closures  significantly extending the scope of first principles nuclear structure calculations. The novelty and challenge of the proposed research lies in (i) the design of many-body frameworks applicable to deformed nuclei, (ii) statistical analyses for uncertainty quantification and (iii) the establishment of tensor network approaches in ab initio simulations. This array of developments, puts me in the unique position to tackle the following big research questions: How does
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Single Cell EPigenomic, Transcriptomic, and structural Rearrangement profiling to investigate Evolution in prostate cancer' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Prostate cancer (PrCa) is the most frequently diagnosed cancer in men in the European Union (EU), and is a molecularly and clinically heterogeneous disease. Although the genomic and transcriptomic landscapes of PrCa have been characterized deeply, the genome-wide epigenetic landscape and its contribution to tumor heterogeneity has received less attention. The lack of single-cell methylation (with parallel single-cell transcriptomic) datasets in solid tumors (and none in PrCA) has stunted inference on clonal evolution. Consequently, the understanding of the coordinated relationship between methylation and transcriptome remains tenuous at best. Structural variants have also not been able to be accurately resolved in cancer due to the reliance on short-read sequencing, and their interplay with DNA methylation is still poorly understood. I present the project, SCEPTRE which is tightly connected to and builds upon ample expertise in the laboratories of Prof. Christoph Plass, Division Chair of Cancer Epigenomics, DKFZ, and Dr. Oliver Stegle, Division Chair of Computational Genomics, DKFZ. Within this project, I will drive the generation of novel ‘single-cell’ and ‘single-molecule long-read’ PrCa datasets, and exploit existing data resources to comprehensively assess the epigenetic and joint transcriptomic and genomic dimensions of human PrCa with the aim to examine cancer evolution. To realize this aim, I will also derive a comprehensive computational toolbox for the analysis of single-cell (and single-molecule) DNA methylation and joint multi-omic profiles. This project will deliver novel innovative ways to identify epigenetic drivers; as well as link DNA methylation for lineage tracing as a biomarker for disease progression. Moreover, the project will uncover putative relat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Investigating the meanings and mechanisms of psychotic experiences in young people: a novel, mixed-methods approach' (2014-2020).

assistant: **Innovation**

Up to one fifth of young people have had the experience of psychotic symptoms, such as hearing voices when there is no-one around, or seeing visions. We now know that young people who experience these symptoms are at increased risk of developing psychotic disorders in adulthood. We also know that these young people are at higher risk of a range of co-morbid disorders such as depression and anxiety, and particularly suicidal behaviours. On the other hand, many of these young people will remain well and, for them, the psychotic experiences were merely a transitory phenomenon.  Childhood trauma is known to be associated with increased risk for psychotic symptoms and is a promising target for intervention. However we do not yet know enough about what types or timing of stressors are involved in the pathogenesis of psychotic symptoms, nor the mechanism by which early life stress may lead to changes in brain structure and function  resulting in symptoms such as hallucinations.  We also need to be able to identify those young people who will benefit most from intervention. This ground-breaking, multi-disciplinary programme of work sets out to address these issues by drawing together epidemiology, social science, anthropology and neuroscience to devise a comprehensive  programme of work examining the relationship between early life stress and psychotic symptoms among young people. Designed as three inter-related work packages, this iHEAR programme will exploit a large population-based cohort and will capitalise on my existing unique cohort of young people, who were known to have experienced psychotic symptoms in childhood, as they enter young adulthood. This iHEAR programme will result in new information which will allow the development of innovative interventions to prevent or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nanoreactivity at drastically Extended Timescales' (NET), addressing dissemination and exploitation.

assistant: **Impact**

SCM is a scientific software company with a track record of over two decades of translating scientific advances into commercial success. The company’s strength has traditionally lied in electronic structure methods, its flagship product being the well-known ADF package. In recent years SCM has been broadening its scope to add approximate, faster methods. One of such methods is ReaxFF, arguably the most transferable reactive empirical force field method and the computational method of choice for atomistic-scale dynamical simulations of chemical reactions.The addition of ReaxFF to our portfolio is a response to market demand, as materials modellers increasingly require accurate simulations of systems involving up to millions of atoms. ReaxFF is a key component of SCM’s medium and long-term strategy, being its module with the fastest-growing demand (and providing over 160% growth in revenues in the last two years.).However, meeting that demand will require important developments, extending ReaxFF to drastically longer time scales in order to achieve large time and length scales with high-accuracy atomistic resolution, currently a major bottleneck for industrial modellers. Such an extension will reduce the need for supercomputing resources and will require the implementation of acceleration techniques, coupling molecular dynamics and statistical mechanics models. This is highly specialized work that falls outside SCM’s strengths in electronic structure methods, and the company needs to recruit skills combining expertise in a range of molecular modelling schemes as well as modern software development techniques.Such an extended ReaxFF would lower the barrier for manufacturing companies to use modelling as a means to becoming more competitive, extending the market for SCM’s R
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Parasitoid life history evolution and climate change', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The chair holder is the Prof. van Alphen (Univ- Leiden, The Netherlands) who wants to come for three years at the UMR ECOBIO for 3 years. He has more than 150 international publications and 3000 citations. For 2007, the UMR ECOBIO, in accord with the regional policy (decrease of water pollution), aims to regroup researchers on the thematic of biological control by insect parasitoids.The research project concerns the fact that modern global change at regional scales is predicted to alter species distribution s, life histories, community composition, and ecosystem function. Concerning the effect of the climate, in ecosystems, tritrophic interactions (plants-herbivorous insects- natural enemies) result from long co-evolved processes under well-defined climatic conditions. Climate change will influence the biology of the interacting species and the stability of these systems.Within this framework, the present project, based on two food-web model (wheat, related pests (aphids) and their parasitoids and larval paras itoids of Drosophila and their Drosophila hosts) aims to do:(1) A comparison of closely related parasitoid species and their host originating from different climatic zones(2) A comparison of life-history traits in populations of a particular parasitoid sp ecies and its host collected along a climatic gradient in Europe(3) Selection experiments on life history traits in the laboratory(4) Measurements of the energy cost of diapause in several host and parasitoids species as well as winter mortality under different temperatures.The training programme implies 6 complementary aspects, and will take 70% of the time of the chair holder:1. Courses at the Master degree (5%),2. Involvement in PhDs by direct co-supervision and by participation to PhDs committees (3 0%),3. To
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The challenging quest for low-mass dark structures'.

assistant: **Concept**

Using strong gravitational lensing, I will constrain with my unique modelling technique and acquired knowledge the properties of dark matter and potentially revise the current standard paradigm for the formation of all structures which is at the core of modern cosmology and galaxy formation theories. Numerical simulations of cosmic structure formation have shown that the amount of mass in low-mass objects depends strongly on the assumed nature of dark matter. My goal is to constrain the nature of dark matter by measuring the dark matter mass function down to ~10^6 M_sol, where the predictions from different currently viable dark matter models differ by large factors.To this end, I will use the gravitational imaging technique, an advanced modelling tool that I have developed and pioneered, and state-of-the-art strong gravitational lensing data for 12 systems observed with cm- and mm-interferometers. At present, this is the only observational probe of low-mass structure in the dark matter distribution beyond the Local Universe. This will represent an important milestone in our understanding of the dark Universe and will provide a key observational test of the Cold Dark Matter model in a regime that has not been probed before. This ERC project will challenge our standard model for small-scale structure formation and will distinguish between “warm” and “cold” hypothesis for the nature of dark matter. This ERC project will have significant implications for the fields of cosmology and galaxy formation.I am in a unique position to achieve the scientific goal here proposed. I have extended experience in studying gravitational lenses and low mass dark structures. I have an unmatched gravitational lens modelling code and high quality data. With this ERC I will build upon my previ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Minimality conditions in model theory' (MINCONDINMT) targeting Sixth Framework.

assistant: **Abstract**

The main objective of this proposal is to continue tee study general model theoretic properties and examples of important classes of structures which are minimal with respect to a certain language, namely weakly o-minimal, C-minimal and P-minimal structures and o-minimal expansions of Boolean algebras. Each of these classes is constrained by certain tight conditions on definable sets in one variable. In the case of weak o-minimalist, especially for weakly o-minimal expansions of real closed fields without definable valuations and expansions of o-minimal structures by convex predicates, I plan to investigate various geometric and topological concepts (like Eller characteristics, smoothness and fineries properties) for definable sets. I will also study definable groups, the theory of weakly o-minimal ordered fields, elimination of imaginaries and expansions of weakly o-minimal structures by convex predicates. I am going to apply techniques developed for weakly o-minimal structures to approach relevant questions concerning C- and P-minimal structures. I am also planning to generalize results (concerning o-minimal expansions of Boolean algebras) from my PhD thesis. I will be mainly working with Prof. McPherson and Prof. Truss, leading specialists in the area of variants of o-minimalist. A part of my PhD thesis is closely related to the research of Prof. Truss (concerning the small index property). Therefore I believe that the results from my PhD thesis and their planned extension will be of great interest to the Leeds model theory group. Through undertaking this project my research will develop smoothly from the area of my PhD to topics (o-minimalist and variants of this notions) intensively studied by many European model theorists. The training through research and through
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SYSTEMS GLYCOBIOLOGY OF GASTRIC CANCER' (GASTRICGLYCOEXPLORER).

assistant: **Concept**

This ITN is built around the biological question of O-glycosylation in gastric cancer for training in systems glycobiology. For meeting the needs of the research goal and for training for future systems glycobiology operations, cross disciplinary international institutes have been identified with top level state-of-the-art glycobioanalytical, glycotechnological and glycobioinformatics platforms. These platforms will be utilized and adopted to address the biology. The researchers will be exposed to academia and industry working together to develop resources of common use for addressing complex biological questions. This has been shown in the area of proteomics, to be a successful way for developing bioinformatics, databases, software, bioanalysis, reagents and biomolecule synthesis/production. These resources are now in use throughout the life science environment in academia, biotech and biopharma. However, there is no individual institute to our knowledge that can prepare new systems glycobiologists for the full impact of the environment they will operate in. This ITN is addressing this deficiency in training, in order to contribute to make Europe a competitive environment for the new generation of multidisciplinary research for complex glycobiological questions. The training to address the systems glycobiology in gastric cancer will provide the researchers with biological and technological workshops and courses in project management and business operations together with bidirectional secondments between academia-industry. Two dedicated training partners have been identified in order to provide efficient on-site training and self studies promoted by E-learning. In the research process we will identify and transfer technologies and biological outcomes for commercializati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Novel remediation strategies for preservation of marble structures endangered from environmental damages', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The objective of this project is to provide a set of rules for Good Marble Remediation Practice (GMRP) based on a multidisciplinary approach involving laboratory experiments in batch reactors and in climatic and salt spray chambers together with atmospheric exposure of various types of marble specimens both untreated and treated. The treatment of the marble specimens will be done both according to practiced approaches and with novel methods such as the adsorption of marble dissolution inhibitors and retardants of the growth of gypsum. Moreover novel remediation methods based on the deposition of calcium carbonate will be employed on the marble specimens. The approach to be followed will be based on model fundamental studies of the dissolution of calcium carbonate polymorphs and marble powders in batch reactors at various conditions of temperature, pH, undersaturation and fluid dynamics. The kinetics measured will be formulated into a law describing the marble dissolution process. This law will provide the possibility of rapid testing of water soluble protective additives. Moreover, extension of the model experiments to marble slabs designed so that their shape will be representative of the mode of atmospheric exposure of the monuments, will be exposed under carefully controlled conditions in climatic salt spray chambers and in the atmosphere, at selected sites representative of the climatic conditions encountered in Europe. The kinetics results obtained from all experiments on the basis of physical, chemical and biological parameters of the marble undergoing weathering will be combined into a predictive mathematical model describing marble weathering. The methodology to be followed is anticipated to lead to the evaluation of the effect of atmospheric parameters on marbl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Technology assessment in europe; between method and impact' (TAMI).

assistant: **Concept**

TAMI creates a structured dialogue between Technology Assessment (TA) experts and decision makers in Science and Technology (S&T) policy area on the issues of method and impact assessment in current European TA. Two teams drawn from major TA institutes throughout Europe will work together with decision makers on a reference system of European S&T foresight processes that identifies best practices relative to policy needs. This will involve a thorough comparison amongst current TA-Methods and identification of impact assessment criteria for their evaluation. The main aim is to improve the ability of TA to provide valuable policy advice and at the same time to maximise the effect of and recognition given to European S&T policy.