RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Reconstruction, processing and analysis of multimodal medical images: applications to pet/spect, mri, ct, ultrasound', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Universidad Politecnica de Madrid (UPM) is the largest technical University in Spain. It has over 2000 professors and around 48000 students. It is organized in technical schools. Research work for this project will be carried out at the Telecommunication Eng. School, which covers mainly the fields of electronics, telematics and communications, having about 260 professors and 3500 students. In the framework of this project, the fellows will get insight on some of the most rapidly growing and interesting areas of medical imaging. They will have the chance to work at a multidisciplinary environment that will provide them with both state of the art informatics laboratory facilities and full access to hospital and health care centres. The fellows will participate to research in the fields of: 3D Image reconstruction: Design, development and optimization of iterative 3D reconstruction algorithms; implementation and application on real PET data for clinical evaluation. 3D Image registration: Development of an intra-subject inter-modality registration for functional (PET) and anatomical (CT, MRI, possibly ultrasound) images, able to register images globally and locally. Parametric imaging, quantification algorithms for dynamic PET studies: Development, analysis and evaluation of methods for the estimation of regional metabolic and transport rates and classification of structures in dynamic PET studies. These will include improvements to existing techniques as well as entirely new contributions in the area. All work will be integrated into a prototype software platform, which will include iterative image reconstruction modules for PET, analysis and further processing of the produced images, modules for registration and fusion with other imaging modalities, as well as visualizati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Impacts of land use policy on environment, wildlife, demographic and socioeconomic indicators in East African savannas - the Serengeti ecological unit' to be submitted under Fourth Framework.

assistant: **Abstract**

The main objectives are as follows:* To analyse the long term outcomes of different land use policies on environment, wildlife, demography and socio-economic indicators in the Serengeti Ecological Unit, which provides a natural experiment with an ecologically and ethnically continuous ecosystem divided into zones of comparable and contrasting policy lying either side of a national border representing major economic and political contrasts.* To use methods from broad-scale to micro-level to interrelate land use policy and economic contexts in the SEU and environs with:- Long term vegetation and habitat change in different blocks,- Changes in human, livestock and wildlife populations with different policies,- Agro/pastoralist responses to land use policy and their implications.* To use statistical and quantitative analyses to help identify proximate causes and driving forces shaping these interrelations, and to develop explanatory models.* To carry out active dissemination by international seminars and publications, and through the national management roles of both DC partners.Expected OutcomeThis research will deliver useful empirical information and a basic structure for analysing, predicting and evaluating land use policy outcomes, as a tool of development and government. It will set up a coherent framework for analysis of economic and ecological implications of policy change, and identify hard outcome measures as reliable indicators of impacts of different policies in terms of economic and ecological change. It will derive explanatory models distinguishing driving forces and proximal causes in the interrelations between policy changes and economic / environmental trends, and provide a test of competing hypotheses over current debates on intensification and degradation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cost Efficient Advanced Leading Edge Structure 2' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The objective is to develop new integrated technology and design concepts for fixed leading edge structure to achieve greater than 30% reduction in recurring manufacturing and assembly cost compared to to-day’s highly fabricated structure. The Project will explore material and processing technology options for both metallic and composite structural solutions that will result in preferred concepts that best meet the critical structural requirements which are defined in the project. A key requirement will be the cost and simplicity of manufacture; however structural performance, in service maintenance, systems access and environmental impact requirements will also feature in a concept and technology selection process. The Project aligns to the FP7 objectives defined in AAT.2008.4.1.2. Aerostructures ‘Development of highly integrated structures with optimum combination of metallic and composite materials …’ and AAT.2008.4.1.5. Production ‘... advanced manufacturing methods to reduce both recurring and non-recurring costs across the whole production cycle ...’. The project is subdivided into 5 operational working packages and one management work package, with organisation of WP’s running from WP1, definition of requirements, through technology development (WP2), concept design and development in WP3 & 4 and conclusions in WP5. The Project consortium is a well-balanced team of European Aerospace OEM’s, all very capable of appropriately assessing and ex-ploiting the competing technologies and design solutions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Autonomous Shipping Initiative for European Waters' (AUTOSHIP).

assistant: **Concept**

While the shipbuilding market has been advantaging Asian lower-cost manufacturing in the last decades, AUTOSHIP will build around two EU industrial market and leading technology providers, such as Rolls Royce and Kongsberg, to create a stronger European cluster able to thrust a market worth Billions of Euros in the next decade, bringing new high-skilled jobs and a safer and greener transport in Europe.AUTOSHIP will build and operate 2 R&A vessels and their needed shore control and operation infrastructure, reaching and going over TRL7. Testing will take place during two pilot demonstration campaigns addressing goods mobility from the Baltic Corridor to a major EU seaport and hinterland, which are most relevant areas with growing waterborne transport market demand in EU. Doing so, it will speed-up the Next Generation of Autonomous Ships, by demonstrating in real environment Short Sea Shipping and Inland Water Ways autonomous vessels. The technology package will include full-autonomous navigation, self-diagnostic, prognostics and operation scheduling, as well as communication technology enabling a prominent level of cyber security and integrating the vessels into upgraded e-infrastructure. In parallel, digital tools and methodologies for design, simulation and cost analysis will be developed for the whole community of autonomous ships.AUTOSHIP will help ship operators/owners to improve the economy of scale of their investments, to effectively gain competitiveness and renew their fleets, making them more competitive to replace road transport.The project’s ambitions will leverage on advanced KETs, solid industrial, investment and business worldwide, participation in all major stakeholders’ organisations. The high ambition is to deliver the technology on the market in 5 year
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Membrane-active peptides across disciplines and continents: An integrated approach to find new strategies to fight bacteria, dengue virus and neurodegeneration'.

assistant: **Innovation**

Peptide-lipid interactions are critical in several biomedical matters that seem uncorrelated at a first glance. MEMPEPACROSS deals with some of these: 1) Lipid membrane-interactions are the key for the understanding of dengue virus assembly and can constitute a target for its inhibition. Viral hemorrhagic fever caused by dengue virus is a serious threat to Europe, as its vector is already present in several European Countries and the virus can easily be introduced. 2) Gene-encoded antimicrobial peptides (AMPs) are innate defenses to prevent colonization and infection by microbial pathogens. Most these peptides strongly interact with lipid membranes. Their antimicrobial efficacy and the difficulty of the target organism to develop resistance make AMPs promising candidates for new generations of drugs to fight highly threatening antibiotic-resistant strains of pathogens. 3) Peptide-membrane interactions are also relevant for neurodegenerative diseases, such as Alzheimer disease. The identification of the conditions necessary for the triggering of the disease-inducing protein aggregation and the search for strategies to inhibit these processes are the key-aspects to be addressed. The societal impacts of the scientific matters to be addressed are golden opportunities to improve public awareness of Science. The project includes a strong component of Science communication and management. The expertises of two European institutions – Institute of Molecular Medicine (Lisbon, Portugal) and Pompeu Fabra University (Barcelona, Spain) – and of three Brazilian institutions – the Federal Universities of Rio de Janeiro and Ceará, and the Oswaldo Cruz Foundation – will come together with common goals and a concern for the: 1) improvement of the scientific state-of-the-art, 2) effective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Multidimensional analysis of signaling during normal hematopoietic differentiation and stress-induced regeneration'.

assistant: **Concept**

Hematopoieic stem cells (HSCs) are characterized by their ability to self-renew and differentiate into cells of all hematopoietic lineages. During steady-state, HSCs are mostly quiescent and responsible for normal hematopoietic differentiation. In cases of stress such as infection or injury, HSCs need to be activated and repair the hematopoeitic system in a regenerative response that involves synchronous and hierarchical replacement of the hematopoietic lineages. Multiple signaling pathways constantly specify a complex network of stimuli that HSCs need to decode and act on. Rapid recovery after injury is crucial for patients receiving myeloablative treatments, or suffering from a hematologic malignancy. It is therefore important to understand how signaling pathways control HSC responses during normal hematopoietic differentiation and stress induced regeneration. Our goal is to use zebrafish genetics and genome-wide techniques to understand how signaling pathways synergize and integrate with the internal hematopoietic program and control normal hematopoietic differentiation and stress-induced regeneration. Ultimately our approach may reveal new players of hematopoietic regeneration that can be exploited therapeutically.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Involvement of invariant chain in antigen processing and presentation in dendritic cells' to be submitted under Sixth Framework.

assistant: **Abstract**

The processing and presentation of antigenic peptides on MHC class II molecules are an important prerequisite of the immune system to be able to defend against invading pathogens, monitor self-reactivity, and fight tumour cells. These delicate antigen presentation pathways regulating the generation of MHC class II peptides require a multitude of different compartments and proteases within the cell, which need to be clarified. In the proposed project, confocal live cell imaging will be used to investigate the involvement of MHC class II associated invariant chain (Ii) in antigen processing and presentation in different dendritic cell (DC) populations.DC is recognized as the most potent antigen presenting cells with the unique ability to initiate and maintain primary immune responses. Using Ii knockout mice with MHC II/GFP knock-in (MHC II/GFP Ii-/-) as well as imaging techniques like fluorescence recovery after photobleaching (FRAP), the concise trafficking of distinct molecules will be visualized in live cells in dependence of various Ii mutants. Moreover, functional consequences of these Ii mutants on the T cell stimulatory capacity will be determined. By gene profiling, differences between mature DC populations using distinct pathogenic stimuli will be analysed, with special emphasis on the effects on their T cell stimulatory ability.Furthermore, the function of the Ii splice variant p41 will be determined. Only by precisely knowing the possible targets of pathogenic and tumorigenic interference will it be possible to improve existing and develop new clinical approaches using DC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Congress to develop consensus among network partners on the concept : global cancer management : towards a european model.""'.

assistant: **Concept**

Consensus was reached in a closed European workshop on Cancer Control Planning Instruments and Network Partners QLG4 2000.300.45. This congress is the second step to disseminate the concept to the care providers as political organisations, professional organisations and institutions. The model is a research product of assets of a cancer control plan, evaluation of measures and resources to quality controlled activity in the available health systems. Ranking structures and performance against expected outcome should lead to a network of partners in several levels of development. Outcome based research will evaluate the response of initiation of this plan on ethics, equal rights, evidence based medicine in a multidisciplinary cost effective model involving stewardship of government and patient rights .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'An emerging eastern problem for the European Union - compliance with EU rules in the new member states of East Central Europe' under Sixth Framework.

assistant: **Concept**

The project analyses the compliance with European Union (EU) rules in the new member states of East Central Europe (CEECs) after their accession. Recent research on compliance in the EU has started to challenge the widespread notion that the EU faces a general compliance problem and a particular 'southern problem'. This project contributes to the research programme on compliance by analysing a set of countries that should present a 'hard case' for the EU's compliance system, but have not been subjected to a systematic, theoretically informed analysis.High adjustment costs and capacity limitations create unfavourable conditions for compliance in the new members. The project's empirical objective is to establish to what extent compliance problems after accession materialise and how they can be solved. The conceptual goal is the development of a theoretical framework to specify the conditions under which the CEECs comply with EU rules.The analytical framework focuses on three sets of factors that affect compliance. First, the project analyses the impact of the mode of rule transfer to the CEECs during the pre-accession period. It examines whether incentive-driven rule adoption is more likely to result in post-accession compliance problems than rule adoption that occurred through a process of social learning. Second, the project analyses the impact of societal mobilisation in the CEECs, which affects the effectiveness of the EU's decentralised supervision mechanism at the national level. The project will thus focus primarily on policy areas in which EU rules promote diffuse 'civic' interests in the CEECs, for which mobilisation problems should be particularly salient.Finally, the project examines the impact of different compliance strategies used by the EU. It assesses the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'INQUIRE- inquiry-based teacher training for a sustainable future' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The science education community agrees that pedagogical practices based on IBSE methods are more effective. But the reality on the ground is different. For various reasons, this type of teaching is not practiced in most European classrooms. INSPIRE counteract this by developing and offering a one-year practically based IBSE teacher training course that will reach out to hundreds of teachers, and in turn thousands of children, in 11 European countries. The course is run through 14 Botanic Gardens and Natural History Museums - some of Europe’s most inspirational cultural and learning institutions. These places act as catalysts, training and supporting teachers and educators to develop their proficiency in IBSE and become reflective practitioners. Most of the partner institutions have experience in delivering IBSE. To ensure excellence, theoretical rigour and project progression, two highly regarded science education research institutions participate: King´s College UK (informal learning; practitioner’s research) and University of Bremen BRD (research into teacher education). The training locations, the practical nature of the course, the support offered and the subject content encourages teachers and educators to enrol in INSPIRE courses and try out IBSE in their everyday teaching. Biodiversity loss and climate change are the major global issues of the 21st century and many teachers are looking for innovative ways to tackle these subjects. INSPIRE training supports teachers to do just that and introduce them to institutions where children can carry out ‘real’ investigations and see science in action. INSPIRE training courses are promoted through national systems that support professional development for teachers as well as informal education training networks. The website
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Interactions between predictive coding and predictive timing in audition: characterizing the role of rhythm in repetition suppression through entrained brain oscillations'.

assistant: **Concept**

The present project seeks to bridge between two important lines of research in current systems neuroscience in order to enlarge our understanding of the brain’s representation of the acoustic environment. The first line investigates the neuronal mechanisms underlying auditory sensory memory trace formation. This constituted the backbone of the applicant’s PhD thesis and as well, is a major emphasis of the research group lead by Dr. Carles Escera at the return host organization of this proposal. The second line investigates the role of low-frequency neuronal oscillations tuned to environmental rhythms in dynamically shaping the excitability of neuronal ensembles, and constitutes a major topic of the research group lead by Dr. Charles Schroeder at the outgoing host organization of this proposal. In this project, both lines of research will be bridged by a series of experiments conducted in both human and nonhuman primates, aiming to unravel the neuronal mechanisms underlying the formation of internal models of the acoustic environment. In short, we seek to characterize the role of brain oscillations entrained to stimulation rhythm (Predictive Timing) in modulating neuronal adaptation to stimulus statistics (Predictive Coding) at cortical and subcortical stages of the auditory pathway, integrating information obtained at a neuronal macro-scale, observed with human electroencephalography, with that obtained at a micro-scale, observed with laminar profiles of post-synaptic potentials and neuronal spiking activity in macaques. The outcomes of this project will provide both a significant step towards understanding the predictive nature of the brain’s representation of sensory events, and new empirical bases for developing theoretical models of perception. These models will in