RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'COre subsystem for delivery of multi-band data in CAtv networks' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

In recent years, unprecedented progress was been made in improving global interconnectivity that has accelerated the creation, exchange, and consumption of ideas and information without regard to geographical boundaries. Significant barriers still exist between the Internet backbones and the average consumer's computer. That last kilometre" access network to reach an individual's home is still constrained by technology inefficiencies and other challenges.The Hybrid Fibre-Coax access network of today's Cable Television operators is an ideal platform for substantially increasing access bit rates, but has yet to be exploited for its full 5Gbs (80-860 MHz of downstream spectrum) potential. Modern modulation techniques allow today's hybrid fibre coax network to deliver data services (including voice and video) but the current technology limits the speed to less than 40Mbps per consumer in the serving area .The CODMUCA project will create technology needed to bridge the gap from 40Mbs to Gigabit delivery on hybrid fibre coax networks. It will allow broadband true convergence of data, voice and video on one protocol and delivery mechanism based upon standard Internet Protocols (IP). CODMUCA technology will scale to support Gigabit/second speeds, without requiring any changes to the current HFC network. The newly available bandwidth will fuel creation of exciting new converged multimedia services, putting Europe at the forefront of innovation and benefiting all EU citizens.CODMUCA will accomplish its goal by researching multiple-channel bonding methods (at both the data protocol level and radio technology area) to create virtual MultiBand data "pipes" that will carry very high-speed data streams to and from the consumer. The new schema will require creation of linearly scalable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Long term carbon dioxide and water vapour Fluxes of European forests and interactions with the climate system' in the context of a Fourth Framework call.

assistant: **Objectives**

To investigate long term fluxes and energy exchanges of representative European forests in order to provide useful parameters to global and regional climate modellers and to analyze the variables that determine energy partitioning by forests in different climatic conditions, including extreme events and stress limitations. To determine the sink strength of European forests for carbon and analyze the variables that determine the gains and the losses of carbon from forests of differing vegetation composition and in different climate regions. To analyze the response of European forests water and carbon fluxes to climatic factors in order to aid regional scale modelling designed to predict impacts of global environmental change on forest ecosystem function. To provide a common data-base of objective data for the validation of forest models, related to growth, partitioning of primary production, water cycling and hydrology. To recommend management strategies for the conservation of carbon stores in forests.Long-term measurements of the fluxes of carbon dioxide, water vapour and energy exchange are carried out at 15 representative forest sites encompassing the entire range in European climate, species distribution, and site conditions. The selected sites are representative of the regional features of the European basin (Mediterranean, Boreal, Continental, Atlantic) and form a unique integrated system for the analysis of climate related ecosystem processes, their impact on hydrological and carbon cycles and test cases for validation of ecosystem models. The methodology used by the 12 participating teams for the measurement of ecosystem fluxes is eddy covariance, which has been standardized in terms of hardware and software among the groups to obtain reproducible and comparable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Modelling in vivo lineage reprogramming of human astrocytes into induced neurons in the adult mouse brain' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Studies during last decade have shown that the genetic programs underlying cell identity are plastic even in fully differentiated cells. Direct lineage reprogramming takes advantage of this plasticity to induce cell fate conversions from one cell type into another. The host laboratory is among those who have pioneered successful lineage reprogramming of glial cells into induced functional neurons in vitro and in vivo. These studies have largely focused on murine glia. While there is sparse evidence that also human glia can be reprogrammed into induced neurons, it is unclear whether such lineage conversion can occur within the constraints of the in vivo tissue context by fully integrated mature human glia. In this project I propose an experimental model to study direct lineage reprogramming of human astrocytes into induced neurons at distinct developmental stages within the context of the adult mouse brain in vivo. This model is based on previous findings that show that human astroglial progenitors can integrate into the mouse brain following grafting, maintaining hallmarks that are specific to human astroglia which differ markedly in their complexity from their murine counterparts. Here I will combine this model system with the directed glial differentiation of induced human pluripotent stem cells (hiPSC) and state-of-the-art genome-editing via CRISPR-Cas9 technology. This will enable me to derive transplantable glial progenitors that can be induced to undergo lineage conversion in a humanized in vivo context at distinct maturation stages. With this approach I will obtain important insights into the fundamental question of how the state of maturation and functional integration determines the capacity of human astroglia to undergo lineage conversion into functional neuro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Investigating RINA as an Alternative to TCP/IP' (IRATI) under Seventh Framework.

assistant: **Objectives**

Driven by the requirements of the emerging applications and networks, the Internet has become an architectural patchwork of growing complexity which strains to cope with the changes. Moore's law prevented us from recognising that the problem does not hide in the high demands of today's applications but lies in the flaws of the Internet's original design. The Internet needs to move beyond TCP/IP to prosper in the long term, TCP/IP has outlived its usefulness.The Recursive InterNetwork Architecture (RINA) is a new Internetwork architecture whose fundamental principle is that networking is only inter-process communication (IPC). RINA reconstructs the overall structure of the Internet, forming a model that comprises a single repeating layer, the DIF (Distributed IPC Facility), which is the minimal set of components required to allow distributed IPC between application processes. RINA supports inherently and without the need of extra mechanisms mobility, multi-homing and Quality of Service, provides a secure and configurable environment, motivates for a more competitive marketplace and allows for a seamless adoption.RINA is the best choice for the next generation networks due to its sound theory, simplicity and the features it enables. IRATI's goal is to achieve further exploration of this new architecture. IRATI will advance the state of the art of RINA towards an architecture reference model and specifications that are closer to enable implementations deployable in production scenarios. The design and implemention of a RINA prototype on top of Ethernet will permit the experimentation and evaluation of RINA in comparison to TCP/IP. IRATI will use the OFELIA testbed to carry on its experimental activities. Both projects will benefit from the collaboration. IRATI will gain ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Functional Pharmacogenomics of G Protein-Coupled Receptors' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The objective of the programme is to study the novel G protein-coupled receptors (GPCRs) derived from the recent knowledge of the human genome, and useselected members of them as drug targets. The partnership involves leading academic laboratories and biotechnology companies dedicated to GPCRs, which cover all aspects of target validation and early drug development. A large collection of orphan GPCRs will be studied in parallel. The distribution of these receptors will be studied in normal and diseased tissues, using a range of techniques. Cell lines expressing orphan receptors will be used for functional screening of a large collection of peptide and protein fractions from natural sources, in order to identify the natural agonists of these receptors. The active compounds will be purified, and their structure determined by mass spectrometry. Random peptide libraries will also be screened with the aim of identifying surrogate ligands.The pharmacology and function of the newly characterised receptors will be determined in vitro, in vivo and in transgenic models. Finally, chemical libraries will be screened on receptors selected as drug targets, and leads will be optimised with the help of receptor modelling and structural studies. The molecules developed in this frame will be tested in animal models, with the aim of partnering subsequent steps of drug development with pharmaceutical industries. We expect to identify natural or surrogate ligands for about 6 orphan receptors over the three years of the programme.A number of recently characterized receptors, for which patent applications have been filed, will allow initiation of the target validation and lead development steps of the programme immediately. A patent portfolio will constitute the basis of further developments
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Penetrating microjets in soft substrates: towards controlled needle-free injections'.

assistant: **Objectives**

The needle-free delivery of liquid jets into soft and heterogeneous substrates, e.g. human tissue, has been hindered by (1) the need to reach specific penetration depths with energy efficient means, (2) the break-up of jets that impedes control over the dose delivery, and (3) liquid splash-back after impacting the substrate that cause cross-contamination between injections. BuBble Gun is aimed at overcoming these challenges. My team and I have recently uncovered new operational regimes of cavitation with continuous-wave lasers. My next goal is to study the energy partition between the creation of bubbles, the formation of liquid jets, and the penetration of these jets into soft substrates. Fundamental insights on energy partitioning will then be applied to achieve major breakthroughs in jet injection, by (1) controlling cavitation within microfluidic confinement, (2) tuning the rheology of jets emerging from confined cavitation, and (3) deriving the relationships between fluid dynamics and material properties governing jet injection into soft substrates. I expect to advance the knowledge at the intersection of microfluidics, physics, and bioengineering, to enable unprecedented control over cavitation, jetting, and injection phenomena. We will develop a portable energy- efficient injection platform by using ultra-high-speed imaging, and quantifying injections with experimental resolutions below the microsecond and micrometer scales. The rheological properties of the jets will be tuned with biocompatible additives to ensure cohesion, before injecting them into in-vitro targets and ex-vivo skin. Numerical models will assist untangling the influence of microfluidic configuration and material properties on the injection outcomes. The ultimate result will be the predictable,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Scouting High Performance Steels for Gears and Bearings'.

assistant: **Objectives**

The HIPSGEAR (scouting HIgh Performance Steels for GEARs and bearings) project supports the aims to demonstrate technologies for an Integral Drive System (IDS) engine concept. The gearbox system requirements, transferring power from the fan to the low pressure turbine, lead to the need of new innovative high strength materials for critical components in particular bearings and their integration with the surrounding components (e.g. gears).The tasks and technical objectives are in particular:• definition of new technologies to meet bearings and gears life and reliability requirements under the expected operation conditions and technology development steps;• demonstration of the improvement of the new technologies through experimental tests for the bearings and gears life and wear resistance evaluation;• demonstration through experimental tests for the applicability of the new technologies to gear materials to optimum bearing integration.The activity will be managed with a Phase & Gate approach and will include detailed technical / program documentation, including planning, drawings, design report, risk analysis, test plan and test requirements, test results and test analysis reports.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrating novel data, artificial intelligence and molecular behaviour to expand functional characterization of intrinsically disordered proteins' (IDPfun2).

assistant: **Concept**

Nearly two decades ago, the unveiling of intrinsically disordered proteins/regions (IDPs/IDRs) disrupted the longstanding structure-function paradigm, challenging the notion that well-defined native protein structures are indispensable for function. IDPs possess the unique ability to sample ensembles of different three dimensional conformations, leading to transition pathways that have a crucial role in various unique molecular functions. However, despite their importance, our understanding of IDPs is limited due to the challenges of studying such dynamic and large molecular systems experimentally, relegating their characterization to computational methods.Although the recent breakthrough in artificial intelligence (AI)-based protein structure prediction methods has raised the awareness of the scientific community about the IDR prevalence in proteomes (up to 50% of residues in higher organisms), their ability to predict reliable IDP ensembles and explain their function remains completely unexplored.Building upon the IDPfun Consortium and in collaboration with the ELIXIR IDP Community and the ML4NGP COST Action, the proposed IDPfun2 Consortium brings together 7 European and 5 Argentinian leading institutions with complementary expertise in data management, machine learning and structural biology. IDPfun2 will combine state-of-the-art AI-based computational technology and novel data to advance the characterization of IDPs and their molecular behaviour also taking into account alternative molecular and evolutionary contexts. The Consortium will establish new standards and formats to better grasp the complexity of IDPs and provide training ground for a new generation of scientists. The ultimate goal of IDPfun2 is to translate the acquired knowledge into major international
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Charting Cell Type-Specific Nucleic Acid Immunity'.

assistant: **Concept**

Metabolic and immune pathways form an intricate network that maintains homeostasis. We recently unveiled that the Stimulator of Interferon Genes (STING), central to triggering cytosolic dsDNA-dependent type I Interferon (IFN) responses, inhibits the desaturation of essential dietary polyunsaturated fatty acids (PUFAs). STING thereby controls the generation of long-chain PUFAs (LC-PUFAs) that in turn inhibit STING activation. This double negative regulatory feedback loop operates as a key rheostat of homeostasis.Interestingly, we found that metabolic tissues, such adipose tissues, express low levels of STING, and that in vitro adipocyte differentiation leads to STING downregulation, although they retain their ability to produce type I IFNs in respond to nucleic acid challenge. This suggests that alleviating the STING-dependent inhibition of PUFA metabolism may result from, or be required for, adipocyte differentiation or functionality. Further, this also suggests that adipocytes may possess specific STING-independent cytosolic nucleic acid detection pathways. Thus, nucleic acid detection pathways and PUFA metabolism should be interrogated concertedly, at the cellular levels, within metabolic tissues, to uncover how they define tissue-specific immune responses and regulate tissue homeostasis, in particular in pathologies presenting with chronic STING activation.Within SENTINEL, we will combine state-of-the art biochemistry and molecular biology approaches, and cutting-edge omics tools, in vitro and in vivo to identify nucleic acid detection machineries and question the role of STING downregulation in metabolic cells. Finally, we will explore the impact of STING-dependent metabolic alterations in pathologies presenting with chronic STING activation. SENTINEL will thus char
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development of an unified energy wear approach to quantify the wear rate from nano to macro contact size range: Application to the Fretting Wear Problem'.

assistant: **Innovation**

Wear induced by debris formation and ejection is becoming a critical problem in many industrial applications. Fretting wear associated to small oscillating sliding displacement is considered as a plague in many contacted systems submitted to vibrations loadings (aeronautics, energy, biotechnology, nanotechnologies etc …). Hence, there is a critical interest to formalize wear degradations and wear rates to predict the contact endurances. Unfortunately, the current formalisms (Archard's law etc …) are still empirical and can take into account the contact size effect. Developing a micro-macro description of fretting wear phenomena, the applicant has recently introduced an extended energy wear formulation which permits to take into account the contact size effect. However, there is now a critical interest to optimize this approach for micro-nano contact scales. Hence, the objective of this IOF project is to extend this research through a 14 months mobility at the Department of Materials Science & Engineering (Nanolab / Suresh group) of MIT (USA). By coupling experimental and modeling developments our common objective is to develop an unified wear approach to quantify the wear rate from nano to macro contact size ranges. In addition to this scientific objective, this IOF project will permit the acquisition of competencies on nano tribology and research management that will be transferred after the return phase to the LTDS-DFI group (France) headed by the applicant.