RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Early diagnosis, treatment and prevention of mood disorders targetting the activated inflammatory response system'.

assistant: **Concept**

Partners come from 10 European countries to achieve two main objectives:  A) The further exploration of 3 animal models (the OBX rat, GS rat and NOD mouse) characterized by an activated immune response system (IRS), an abnormal tryptophan catabolism and a depressive-like behaviour to study the pathogenesis of inflammation-related mood disorders and the efficacy/working mechanism of anti-inflammatory and tryptophan metabolism restoring drugs.  B) The in-parallel study of mood disorder patients to validate two sets of already developed biomarker tests to identify patients and individuals at risk for a mood disorder and characterized by an activated IRS to be able to treat these patients/individuals with drugs counteracting the consequences of the activated IRS/disturbed catabolism of tryptophan. Five strategic approaches (broken down in 12 workpackages) are used:  1) Study of the animal models for depressive-like behavior and aberrancies in monocytes/ macrophages, the tryptophan metabolism and the microglia-astrocyte-neuron interaction.  2/3) The validation of a high-throughput biomarker mRNA blood monocyte signature test and a biomarker test to detect an abnormal tryptophan catabolism.  4) Correlation studies between the outcomes of these biomarker tests in patients to various clinical variables, a.o. gene polymorphisms and the brain scan.  5) The therapeutic targetting of the activated IRS/abnormal tryptophan catabolism using a PDE4 inhibitor, a COX-2 inhibitor and a KMO-inhibitor in the animal models and in a phase II intervention study in depressed patients. Novel approaches are the prospective assessment of patients/individuals to identify whether changes in the IRS have any prognostic value and that the program aims at a personalized treatment of patients on the bas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Synthesis & spectroscopic characterization of model peptides, labelled with stable isotopes such as 13c, 15n and 2h' under Fourth Framework.

assistant: **Concept**

As an HCM fellow, at University of Uppsala, I trained on asymmetric synthesis of amino acids labelled with stable isotopes, such as 13C, 15N, 2H. These labelling methods consist a new and important tool in NMR structural studies of labelled peptides, to gain information about conformation and microstructure. I applied for a return home fellowship to continue this work with the synthesis of model peptides labelled with stable isotopes, primarily for NMR studies. Right after my return to Greece, I plan to set up a research lab at Department of Chemistry, University of Ioannina, and to teach the techniques of asymmetric synthesis and labelling of amino acids to graduate students, which will decide to join the project. These methods are absolutely new in Greece and we will collaborate with the research group of Prof. C. Sakarellos. Next step will be incorporation of these labelled amino acids into simple model peptides, which will be studied by NMR.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Designing catalysis: Nitrogen-carbon ylids as methylene donors' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Catalyst optimization is currently predominantly done by screening a large number of catalysts, rarely catalysts are designed by either chemical intuition or molecular modelling.In this proposal we will try to develop -by design- a new catalytic protocol using environmental benign reagents for the synthesis of cyclopropanes. The inspiration for this work stems from an interesting historical anomaly.In early work of Nobel prize laureate Georg Wittig cyclopropanation by the reaction of N-C-ylids as methylene donors with olefins was reported. Later these results were retracted. Possibly, traces of transition metals in one of the reagents were responsible for these inconsistent results. This observation prompts us to start an investigation of the interaction of N-C-ylids with transition metals.In this proposal we will combine (in)organic synthesis, mass spectrometry and molecular modelling to study the interaction of N-C-ylids with transition metals. Thorough understanding of these reactive intermediates will lead to novel synthetic (ideally catalytic) routes to cyclopropanes and the use of these intermediates in related synthetic transformations.Thus testing, validating and further developing our tools for design of catalysis and providing a environmentally benign industrial route to cyclopropanes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Spin Electron-Phonon in 2D materials', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Electronic-structure theories allow us to simulate and predict the properties of novel materials and devices. The last 15 years have seen the development and application of techniques dedicated to the study of electronic excitations and atomic degrees of freedom. We are now witnessing a next phase in predictive electronic-structure theories, whereby the interactions with the environment are taken into account. Here, we focus on the interactions between a quantum object and its crystal lattice, taking into account the spin degrees of freedom and the spin-orbit corrections, central to the behaviour of some of the most exciting materials under intense study these days, from transition-metal dichalcogenides to topological insulators to qubits for quantum technologies.In this project we will develop the computational tools, and apply them, to study transport in low-dimensional materials from first-principles, taking into account spin-dependent electron-phonon coupling. Only by doing this it will become possible to describe with predictive accuracy key properties that affect electronic and spin transport, and are fundamental in spin field-effect transistors, spin filters, spin diodes, spin qubits, spin Hall effect or spin locking. In particular, the researcher will (i) implement spin-resolved electron-phonon coupling in widely used open-source first principles software; (ii) use it to study spin-dependent and spin-independent transport properties in two dimensional (2D) materials, focusing on transition-metal dichalcogenides monolayers and; (iii) create and deploy the first open access electron-phonon database of 2D materials. This Marie Sklodowska-Curie fellowship will allow the researcher to work in a university environment and group at the forefront of first-principles mod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Novel ceramic thin Film based Scintillator for high resolution X-Ray imaging'.

assistant: **Concept**

X-ray imaging devices are powerful tools, which provide information about the inner structure of samples during non-destructive examination. However, a range of applications such as studies of early formation stages of metallic foams or conveyor-belt inspection suffer from poor spatial resolution and limited Detective Quantum Efficiency (DQE) of scintillator materials which are used in the detectors available at the moment. The basis of our proposal is the development of new thin layer scintillators for hig h resolution imaging using X-radiation.The proposed project contains the development and optimisation of production processes of substrate and thin layer using Liquid Phase Epitaxy, transfer of these processes to an industrial partner, characterisation of the novel scintillators and tests for different applications with X-radiation from synchrotrons and X-ray tubes. The project will focus on Lu2SiO5:Eu (LSO:Eu) to improve the Detective Quantum Efficiency of the detector.The high absorption efficiency of this ceramic material promises an obvious improvement in the light yield, while the possibility of microstructuring can lead to an improvement in the spatial resolution, especially at high energies. Additionally by applying an anti-reflex coating the wave-guiding effect can be suppressed leading to a higher image quality. Combining these new scintillators with suitable electronics will result in an optimised type of compact X-ray detector. Due to the higher DQE the new scintillator will allow X-ray tomography of medical and biological samples with lower radiation exposure.The usage of such systems in automated inspection systems will improve the product safety. The advanced spatial resolution even at higher energies and reduced exposure times are interesting aspects f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Capacity-building in Arctic standardisation development', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

CAPARDUS is a CSA project under H2020 with focus on capacity-building to develop guidelines, practices and standards in selected Arctic topics.  These include data collection and management related to natural resource management, tourism, safety, community planning and decision making. The project develops a framework for development of standards as a collaborative effort between scientists, local communities and other stakeholder groups involved in the case studies in Greenland and Svalbard, with contribution from studies in Alaska and Yakutia in Russia. The project organizes a number of workshops, dialogue meetings and research schools as part of case studies in local communities, showing how the social-environmental systems are changing Arctic communities and what are the drivers for these changes. The climate change and its consequences in the Arctic leads to new requirements for planning and decision-making based on scientific and economic data, assessments and predictions. A prerequisite for good planning is access to data and information of relevance to the operators in the Arctic. CAPARDUS promotes and supports the Community-Based Monitoring and Citizen science as a contribution to data collection and knowledge building. The project will provide requirements and recommendations for an Arctic Practice System  to the benefit of both local communities and other actors in the Arctic. At the end CAPARDUS will summarize the emergence of guidelines, practices and standards, supporting a sustainable development in the Arctic.


**Keywords:** Guidelines, standards, best practices, local communities, digital resources
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Delineating the kinetic RNA interactome of nuclear exosome adaptor complexes' (EXOonRNA) under Horizon 2020.

assistant: **Objectives**

The human genome is ubiquitously transcribed into far more RNA than is immediately needed. Consequently, RNA turnover becomes critical for keeping our cells healthy. The nuclear RNA exosome degrades the majority of short-lived RNA species within cell nuclei and is hereby the gatekeeper of an enormous RNA synthesis output. To perform this essential task, the exosome employs so-called ‘adaptor complexes’ (ExoACs), which contribute to target specificity. While the trimeric nuclear exosome targeting (NEXT) complex is specifically required for the degradation of short RNA transcripts, the poly(A) tail exosome targeting (PAXT) connection recruits the exosome to longer polyadenylated RNAs. Interestingly, and in contrast to NEXT, PAXT exhibits a rather complex nature. Besides the integral component RNA helicase MTR4 and the large scaffolding protein ZFC3H1, the proteins PABPN1, ZC3H3, and RBM26/27 participate in the RNA-targeting of PAXT. How assembly of all these proteins is achieved to commit a polyadenylated RNA for decay and how it is balanced with other nuclear RNA metabolic processes to avoid untimely decay of mRNA is unknown.Here, I will track the interaction of the RNA-binding components of NEXT and PAXT with newly synthesized RNA in human cells using a novel and cutting-edge temporally resolved CLIP (T-CLIP) methodology, which combines nascent RNA labeling using photoactivatable ribonucleoside analogue 4-thiouridine with the time course of UV crosslinking of protein-RNA complexes. Since the T-CLIP approach allows us to link ExoAC interaction profiles to RNA synthesis and turnover data, I will define the positioning and timing of ExoAC component interactions with nuclear RNA in real-time to understand how nuclear exosome identify and eliminate nonfunctional RNA. In achi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Stem Cell Therapy Development for Corneal Epithelium Regeneration' to be submitted under Horizon Europe.

assistant: **Abstract**

Corneal disease ranks as the fourth major cause of blindness, imposing a significant medical, social, and economic burden. Effective therapeutic options for corneal disease are unfortunately limited. The development of regenerative treatment has proven more complex than anticipated. Bridging the gap between cutting-edge scientific and technological advancements and their clinical applications in ocular regenerative medicine requires equipping the next generation of (medical) researchers with comprehensive training to drive innovation and facilitate clinical translation. STEM-CORE aims to reshape European doctorate education, through ‘training through innovative research’, nurturing future leaders in ocular regenerative medicine and beyond. This training program offers doctoral candidates (DCs) a comprehensive training trajectory to develop a robust, affordable, and sustainable cell therapy for treating corneal blindness caused by stem cell deficiency. Key components include in-depth understanding of stem cell differentiation, developing (genetically corrected) cell products and biomaterials, and evaluating regenerative function of the cell products in corneas. Through innovative, interdisciplinary and intersectoral research, STEM-CORE provides training of a full set of transferable and other complementary skills to DCs that enhances their career prospects across academia and industry. To achieve this, STEM-CORE has assembled a team of leading European researchers and dedicated supervisors from academic and non-academic sectors, whose expertise spans all facets of the training program. We envision that STEM-CORE will not only establish a novel paradigm for cell therapy development but also empower aspiring researchers to tackle broad challenges in future regenerative med
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Piloting Innovative Insurance Solutions for Adaptation' (PIISA).

assistant: **Concept**

The EU Member States should step up their climate change adaptation efforts alongside their intensifying mitigation efforts. Next to and in conjunction with physical and organizational measures, that directly reduce climate change risks, insurance and related risk sharing solutions have an important role to play. Innovative insurance solutions and risk sharing are crucially needed to incentivize adaptation efforts, in terms of both volume and effectiveness, while also directly contributing to building more resilient societies. The PIISA project aims to develop and deploy a range of insurance innovations that incite households and firms to adapt proactively and sufficiently for their own sake and their neighborhood’s sake. PIISA also incites public authorities to set up adaptation and create adaptation promoting conditions. PIISA co-develops climate resilient insurance portfolios and develops solutions for sharing losses and climate risk data. The PIISA project matches scientifically underpinned new insurance concepts with hands-on demonstration of their operability, effectiveness, and acceptability. Extensive user involvement, contextual sensitization, affordability and viability are key features of the new products. The choice of new product developments and sectoral applications will be based on a careful analysis of the adaptation and insurances gaps and their interactions, as well as on deepening product-market feasibility analyses. PIISA focal sectors are agriculture, forest sector, and cities and citizens’ well-being, involving a host of climate enhanced hazards such as floods, droughts, forest fires, biotic risks, and various types of storms. The consortium counts 12 partners from 5 countries. PIISA involves 3 insurance companies who will actively participate in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Coping with Varieties of Radicalization into Terrorism and Extremism' (VORTEX).

assistant: **Innovation**

VORTEX (Coping with Varieties of Radicalisation into Terrorism and Extremism) represents an innovative and integrative doctoral network of practitioners and academics for training of doctoral candidates in radicalization studies. The understanding of radicalization is currently trapped between securitisational approaches and socio-cultural contextual explanations, influencing political agencies, practitioners, and scholars alike. One approach focuses on immediate and short-term security needs of European societies. Another approach stresses long-term structural factors, such as socio-economic marginalization, as a breeding ground for extremism, radicalization, and extremist world views and cognitive mindsets. This DN aims not only to identify a theoretical a methodological gap between the two approaches, but also to develop new evidence-based innovative strategies to countering and preventing ideological and behavioural radicalization. VORTEX will provide an integrated and thus meaningful research programme not only but primarily for doctoral candidates to pursue their research in a fruitful and meaningful dialogue among relevant disciplines and in a dense web of supervision, training and interaction to jump start both successful and relevant careers. Bringing together a network of academic and non-academic participating organizations from 14 countries on three continents, dealing with both religious and secular radicalisation, this DN will explore and compare different varieties of radicalization in several empirical settings. Practice-based research with associated partners, connecting doctoral candidates to future job markets and audiences, will offer the opportunity to investigate radicalisations on several levels, ranging from local to global and from cognitive to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Second generation Methyl MethAcrylate (MMAtwo)' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

PolyMethylMethAcrylate (PMMA) is a well-established polymer for its optical properties. Although PMMA can be turned back into its monomer, the technology has limited applications. Currently what is collected and reprocessed are mostly production scraps, which is about 10 % of the annual PMMA production but a much larger amount of recyclable product is available. On a world scale basis, 10 % of post-industrial scraps and the equivalent of 10 % of post-consumer products represent a potential of a Billion € market. The MMAtwo project main objective is to construct a novel and fast growing PMMA recycling value chain through depolymerization and recovery of a monomer grade sold at 90 % of virgin MMA price. MMAtwo targets to reduce the energy needs by more than 70 % and the CO2 emissions by more than 60 %. To achieve its objective, MMAtwo integrates representative players along the value chain. During the project, PMMA will be collected from production scraps, but also from End-of-Life vehicles, Electronics goods, construction…. The lead-free depolymerization process will be validated at TRL7 enabling the possibility of a first commercial unit soon after the end of the project. A versatile purification process will be validated through repolymerization of the produced monomer. MMA grades produced will be validated in several optical and non-optical applications. The inorganic fractions from PMMA composites will also be valorized. The project will establish standards for post-consumer and post-production PMMA based products in order to facilitate the recycling. Training and education activities will be organized in order to prepare the next generation of Engineers and Researchers in the field of closed-loop polymer recycling. The new value chain will benefit to the entire PMMA