RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Damage mechanism of High Frequency Mechanical Impact (HFMI) Treated Welded Structures under Service Loading to Increase the Fatigue Life for Lightweight Design' (HFMI) under Horizon 2020.

assistant: **Objectives**

The use of high-strength steel (HSS) grades leads to significant weight reduction and increased service life, especially in complex-welded structures. However, their implementation is limited in practice due to the fatigue issues at welds, welds which have the same fatigue life as those in lower strength steels. High-frequency mechanical impact (HFMI) treatment allows for important fatigue life improvement based on the induced compressive residual stress (RS), improved weld shape and cold-worked surface region. In current drafted guidelines, these factors were derived according to the weld toe failures obtained under constant amplitude loading (CAL) and also verified by a limited dataset under variable amplitude loading (VAL), the latter being more realistic of service loadings. Current knowledge on HFMI-improved welds has also shown that fatigue failures may also initiate at other regions, rather than weld toe. In spite of the fact that relaxation of induced RS state has been claimed to be the main reason of different damage mechanisms resulting in the failure location change, scientific questions such as: why, how and under what conditions this effect occurs or what damage mechanisms play a dominant role, remain unanswered. Based on the above context, the objective of this proposed project aims to solve the damage mechanisms of HFMI-treated welds under service loading by considering fatigue tests, investigating the microstructures and developing analytical approaches. The proposed scientific approach includes investigations on the development of grain structure size/orientation through the depth of HFMI groove by neutron scattering, and on the relation of grain-orientation-dependent RS state under service loading. This training will also allow transferring of the obta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Bridging length and timescales of Electronic processes in organic SemiconducTor devices', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The development of the next generation of efficient opto-electronic devices based on organic semiconductors relies on the capability of theoretical modelling to shed light onto microscopic mechanisms underneath and provide a rational approach to materials and devices design. To answer this need, we propose the realization of a general multiscale modelling platform, capable to cover and bridge key aspects at core of device functioning, from supramolecular organization to energetics and time evolution of charge and energy carriers.This novel modelling platform will be applied to obtain crucial insights on exciton dissociation and charge separation in bulk heterojunctions, charge transport in doped materials and multiple exciton generation through fission of singlet excitons. A general and efficient computational protocol for the collection of essential information with state-of-the-art and original theoretical tools at the different levels of resolution, and its injection into effective model Hamiltonians, will endow us with an unprecedented comprehensive and realistic picture of electronic structure and dynamics in heterogeneous and disordered mesoscopic systems. Fully accounting for charge and energy carrier delocalization, intermolecular hybridization and quantum superposition of Frenkel and charge-transfer excitations, this approach has the potential to disclose molecular and supramolecular requirements for an efficient ultra-fast multiplication of excitations and their subsequent splitting through hot charge-transfer states, or for the tuning of semiconductor properties by chemical doping.This research will be undertaken in collaboration with leading experimental and theoretical groups, levering the BEST ambitious profile, and strengthening the European excellence in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'MANUfacturing ecoSystem of QUAlified Resources Exchange' (MANU-SQUARE) targeting Horizon 2020.

assistant: **Abstract**

The MANU-SQUARE project creates a European platform-enabled responsible ecosystem acting as a virtual marketplace, bringing available manufacturing capacity closer to production demand to achieve their optimal matching thus fostering, on the one hand, fast and efficient creation of local and distributed value networks for innovative providers of product-services and, on the other hand, reintroduction and optimization in the loop of unused capacity that would be wasted otherwise.In a wider perspective the MANU-SQUARE project pursues a paradigm shift that disrupts the traditional static supply chain model and establishes dynamic value networks that can be arranged on-demand to couple the needs of buyers and the availability of sellers of manufacturing capacity. In so doing, this latter becomes an easily and efficiently tradable commodity towards lowered production costs for European companies and improved manufacturing ecosystem actual productivity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Classification and longitudinal follow-up of common melanocytic nevi with in vivo reflectance confocal microscopy' under Seventh Framework.

assistant: **Concept**

Nevi are the strongest risk markers of melanoma. Common nevi are still regarded clinically as a single entity, despite data suggesting that nevi consist of distinct subsets, and a new classification reflecting the diversity of nevi is needed. However, classifications by clinical examination or even by low-resolution imaging techniques have been limited by difficulty to correlate with histopathology, the gold standard for diagnosis, and by lack of specific pattern in a substantial percentage of nevi.We propose to harness Reflectance Confocal Microscopy (RCM), a cutting-edge, high resolution imaging technology to more precisely classify nevi and follow their evolution over time. In addition, we will correlate RCM pattern of nevus subsets to their respective histopathologic patterns and characterize their genetic profiles. We will image with RCM common nevi from the back and legs of patients and characterize nevus subsets that show distinctive RCM patterns. We will then test the reproducible assignment of RCM images of nevi to these subsets. After one year, we will repeat RCM imaging of the same nevi and examine whether distinct RCM patterns of nevus subsets are retained over time. In addition, we will identify patients with common, banal-appearing nevi that have been scheduled for excision by physicians outside the scope of the study; we will image these nevi prior to excision and then test whether distinct RCM patterns of nevi correlate reproducibly with unique histopathologic patterns. Finally, we will draw a preliminary link between RCM nevus patterns and their genetic profiles by testing excised nevus tissue for BRAF mutation.The resulting state-of-the-art classification of nevi could impact patient care since different nevus subsets may vary in associated melanoma ri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Tracing the Lost. Understanding and Addressing Disappearances in Contemporary Mexico'.

assistant: **Concept**

Mexico faces one of the most urgent human rights and humanitarian crises in the world, with over 110,000 persons having disappeared, 98% of them between 2006 and 2024, indicating a severe escalation in recent years. Most of these contemporary disappearances are rooted in gender, racial, sexual diversity, class, and migratory status disparities. However, a fundamental problem is the lack of reliable intersectional analyses that could shed light on the specific intertwining of structural attributes that heighten the risk of being disappeared. Without this knowledge, effective strategies and public policies for searching and preventing cannot be developed.In this dire context, the TRACETHEM project will establish a systematic framework to understand and address the massive disappearance of women/girls, Indigenous and Afro-descendant people, migrants, LGBTQ+ individuals, and those who are living in poverty. Firstly, revealing contemporary disappearance patterns. Secondly, fostering long-term collaboration among key actors in developing novel search models: families in their relentless pursuit to find their loved ones, State institutions, and NGOs. This groundbreaking initiative will unite these stakeholders in a sustained critical process, evaluating and comprehending who seeks whom and how to craft tailored search models that may effectively combat and prevent contemporary disappearances. Through cross-sectoral collaboration, where affected families will function as experts rather than just victims, TRACETHEM will design more effective search models, laying a foundation for cooperative and enduring measures and fostering a safer and more inclusive Mexico.The impact of TRACETHEM overflows Mexican borders, as the violence in this country is quickly spreading to Central and S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Global scale-up of GoSleep Pods more than a seat' to be submitted under Horizon 2020.

assistant: **Abstract**

Patented breakthrough innovation is a combination of product and service; GoSleep Pods are fully automatic reclining seats with privacy shade already in use at 25 airports and other locations globally. Wide market understanding helps the optimizing of the products and during this project finalized V2 Pod will be launched. The potential for scaling the service to the new market segment is significant, the next focuses are offices, hospitals, roadside service stations are other terminals.GoSleep Pods are pioneering products on the market and have clearly more suitable features for the airport use than any of a few other competitors. GoSleep brand is already globally known and the brand value is high. Commercialization of GoSleep Pods creates new service market of 505 M€ and up to 3000 workplaces. Benefits include sleeping safety, health, satisfaction and working efficiency for the users. GoSleep Pods provide a solution for a clear user need: privacy during transit is asked by 1.4 billion air passengers globally.GoSleep Ltd. (founded 2011) has a team with enthusiasm and relevant know-how. GoSleep Ltd. has an excellent network of partners in both subcontracting and distribution. GoSleep Ltd. has a realistic target, 30 M€ turnover in 2011. The business strategy is well planned and the products are patented and trademark protected.The Horizon 2020 Instrument Phase 2 project is planned to speed up the global scale-up. The H2020 project will result to; market launch of the new V2 Pod and 60M€ turnover in the next four years, optimized and scaled-up production, optimized business models based on MRR+ thinking, thorough market understanding, scale-up activities and active communication with stakeholders and users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Formulating new Goals for global health, and proposing new Governance for global health that will allow the achievement of these goals' in the context of a Seventh Framework call.

assistant: **Objectives**

The MDGs succeeded in generating consensus on and mobilising resources towards agreed goals. They were less successful at clarifying responsibilities for achieving them. The MDG target on sharing global health innovation is particularly ambiguous about the allocation of responsibilities.The members of the consortium behind this proposal assume that the new goals for global health will need to be based on a broad global consensus on the goals, on accepted national and international responsibilities to achieve those goals, and on the kind of governance that is needed to ensure accountability for accepted responsibilities. They believe that the internationally agreed right to health provides a useful point of departure for the formulation of such a global consensus, that the goals should incorporate universal coverage, and that community input is critical to designing the goals.Consortium members will:* Assess the achievements and shortcomings of the MDG approach;* Consult communities whose health is most compromised on their essential needs and their perception of their entitlements under the right to health;* Assess the capacity of low and middle income countries to meet those needs and entitlements, including to identify where international assistance (financial and technical) or cooperation (on sharing innovation or avoiding the brain drain of health workers) is needed;* Analyse the international political economy of global health and global governance for health, to formulate international responsibility for global health;* Analyse, clarify, and re-affirm national responsibility for health, in the light of international responsibility for global health;* Propose new goals for global health, clarifying national and international responsibilities;* Provide suggestions f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Making national museums: comparing institutional arrangements, narrative scope and cultural integration' (NAMU).

assistant: **Concept**

Reflections on historical culture have not been de-nationalized by comparative approaches to the same extent, as has research on nationalism. Partly, this is due to the fact that Cultural Heritage as a field is one of the complex responses to contemporary challenges attempting at producing and remoulding collective identity with a new frenzy from the 1990s onwards. Furthermore, the competence for analysing public museum culture is multidisciplinary. Therefore, the need and benefit for transnational, transdisciplinary action to connect research and knowledge is extraordinary and of vital concern. By bringing this field together with a sharp and comparative focus on national museums the program will form a new departure for understanding and working with the European diversity in this central institution.The purpose is to develop the tools, concepts and organisational resources necessary for training researchers, investigating and comparing the major public structure of National Museums, responding to challenges of globalisation, European integration, and new media. What are the forces and values of traditional national display in dealing with challenges to national, cultural and political discourse? This will be achieved by a series of conferences providing a venue for younger scholars and eminent researchers from Europe to gather and develop the multi-disciplinary competence necessary to understand and compare the dynamics of national museums in a framework for broader historical culture and identity politics.The series of events will:a) provide a cross-national and cross disciplinary platform for research training at thematically organised conferences.b) stimulate, develop and organise knowledge on the dynamics of national museums to make a reflexive partnership with t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Up-scaling geomorphic hazards from alpine landslide dams' (UPSLIDE), addressing dissemination and exploitation.

assistant: **Impact**

Large landslides can cause significant long-range and long-term, i.e. up-scaling, impacts in alpine river systems such as formation and failure of landslide dams, channel occlusions, diversions, massive debris deposition, channel instability, or avulsion. Landslide dams pose several hazards to both downstream and upstream communities due to potential adverse effects from catastrophic outburst flooding and debris flow, valley-floor inundation, or excessive aggradation from landslide-derived sediment slugs. Convent ional landslide hazard assessments häva so far neglected these off-site impacts, which in many cases may cause more damage than the direct physical impact of the slope failure itself.The proposed project addresses these shortcomings and aims to:(a) compile a world-wide inventory on landslide dams in alpine regions spanning a wide range of environmental boundary conditions;(b) analyse key geomorphometric and morphodynamic data to quantify the total (= compound) hazard from landslide dams; and(c) formulate a predictive model of alpine catchment response and sensitivity to disturbance from large catastrophic landslides and episodes of rainfall- or earthquake-triggered land sliding alike.The key methodology will consist of geomorphometric analysis of a GIS-based landslide-dam inventory compiled from existing national or regional data sets, scientific literature, technical reports, university theses, historical accounts, air photo and satellite imagery, and digital elevation data. This will be complemented by sediment budget studies of selected sites to integrate the morphodynamic history spanning formation, failure, or obliteration of landslide dams. It will further allow quantification and ranking of geomorphic off-site impacts and its integration into assessments
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Chemical Tools to Probe the Role of Bromodomains in the Parasite Trypanosoma cruzi' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Lysine acetylation is a key protein post-translational modification (PTM) found throughout the cellular environment and across the range of species. This PTM is dynamic, with histone acetyl transferases (HATs) acetylating lysine, and histone deacetlyases (HDACs) reversing the modification. In addition, proteins modules bromodomains, have been identified that bind to acetylated lysine (KAc) and mediate protein-protein interactions. In humans, bromodomains exist as part of larger proteins, many of which are involved in transcriptional regulation. Bromodomains contain a KAc-binding pocket for which small molecule ligands have been identified. These ligands prevent the interaction of bromodomains with KAc and have been invaluable in dissecting the fundamental biology mediated by bromodomain-containing proteins (BCPs). We and others have developed potent ligands for the human bromodomain and extra C-terminal domain (BET) bromodomains. These compounds have antiproliferative effects in cancer cells lines and modulate inflammation and atherosclerosis. This work led to an explosion of interest in developing BET bromodomain inhibitors, resulting in 5 compounds in clinical trials. Despite rapid progress in understanding the role of human bromodomains, their function in other species is poorly understood. Given the fundamental role played by bromodomains in humans, we hypothesise that BCPs will play equally important roles in other organisms.To understand the role of non-human bromodomains we will develop small molecule probes to study the function of BCPs in the parasite Trypanosoma cruzi. We have selected T. cruzi for two reasons: 1. Four BCPs (TcBDF1-4) have been discovered in T. cruzi; our collaborator Prof. Serra has cloned these proteins and we have the plasmids; 2. T. cruzi