RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Speech Acts in Grammar and Discourse'.

assistant: **Innovation**

The SPAGAD project will investigate speech acts, the basic linguistic units with communicative function. It is made possible by recent breakthroughs in our understanding of speech acts as devices to change the world by establishing new commitments and constrain the future development of a conversation.  The project will propose a formal model for speech acts. In the light of this model it will investigate the role of speech acts in three areas. It will elucidate their role in grammar in typologically diverse languages: how they are expressed by morphological, syntactic and prosodic means, how expressions like adverbials and clause-embedding verbs can operate on them, and how they can be integrated in a formal model of the syntax/semantics interface. It will investigate speech acts in discourse: how they are used to enrich the common ground, how they can be employed to negotiate conflicts in the development of conversation, how questions, contrastive topics and discourse particles are devices that restrict the development a discourse can take, and how the choice of one speech act out of set of alternatives creates pragmatic effects like bias in questions or politeness in commands. And it will explore speech acts in communication: What are the societal norms of different speech acts, like the prohibition against asserting falsehoods, which strategies can increase or decrease the commitments of speakers, how does the context influence the type of commitments, how do social groups within one language community differ, what are the difference across language communities, how are the societal norms that come with speech acts acquired?  The SPAGAD project will have a major impact on linguistic semantics and pragmatics; it will reconceive them by a model theory based on commitm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A night in the lab' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The main aim of the present proposal is to bring researchers involved in biomedical research closer to the large public, without any distinction of age, gender, level of scientific training or social category. The proposed action intends to oppose the stereotypes about researchers and their profession, giving the opportunity to perceive them as “ordinary people”. On the other hand, in the last years, people have asked to biomedical researchers for more information about their work and the effect on  public health. Therefore, showing a  researcher “from inside”, stressing his/her “ordinary” features could help in attracting people to scientific careers and rise the perception of the  role of researchers in our society . The proposal foresees the organization of a high impact event in the beautiful and ancient cloister of the University of Milan, giving  an opportunity to young and adult people to meet researchers involved in biomedicine and nano-medicine, to see them at work and to work with them, taking  part in real laboratory activities. Buffet, music and a drama show entitled  “The day of a researcher” will create an informal and pleasant atmosphere. Local institution such as “Comune di Milano, Assessorato alla Salute” will support the event.  Sophisticated instruments will also be shown and used during the laboratory activities. An “official” award ceremony  will take place, during which the winners of the photo competition will receive a prize at “Aula Magna” of the University of Milan. A representative of the Municipality of Milan together with a representative of the University of Milan will announce the winners and will describe the award foreseen by the Commission for the winner. The Commission is composed by photographic reviewers known at national and interna
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project '375 Million Years of the Diversification of Life on Land: Shifting the Paradigm?' (TERRA) targeting Horizon 2020.

assistant: **Abstract**

Life on land today is spectacularly diverse, representing 75–95% of all species on Earth. However, it remains unclear how this extraordinary diversity has been acquired across deep geological time. This research project will address this major knowledge gap by reassessing the dominant paradigm of terrestrial diversification, an exponential increase in diversity over the last 375 million years, using the rich and well-studied fossil record of tetrapods (four-limbed vertebrates) as an exemplar group. Previous analyses of tetrapod diversification have been based on an outdated and problematic dataset that is likely to artificially inflate apparent diversity towards the present day. A major new dataset will be assembled, detailing the spatial and temporal distribution of terrestrial tetrapods across their entire fossil record in unprecedented detail. These data will be analysed using the latest approaches to sampling-standardisation in order to generate completely novel, rigorous curves of diversification through time. These will be compared within a cutting-edge statistical framework to alternate diversification models, as well as to changes in rock record sampling, global environments (e.g. sea level and atmospheric composition) and marine diversity. These comparisons will allow us to address the following key questions: (i) Does terrestrial diversification follow an exponential pattern over the last 375 million years? (ii) Is the terrestrial fossil record as complete as the marine fossil record? (iii) Are long-term patterns of terrestrial diversification driven by physical changes in the Earth system such as climate change? (iv) Did marine and terrestrial biodiversity follow similar trajectories across geological time? (v) How severely did mass extinction events impact u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integrated Environmental Monitoring, Forecasting and Warning systems in Metropolitan Areas' (EMMA), addressing dissemination and exploitation.

assistant: **Impact**

The project aims at meeting users' needs in the field of air quality monitoring, forecasting and warning by the introduction of innovative telematics and integrated multimedia systems.The work will be carried out in the following cities: Genoa, Leicester, Madrid and Stockholm.The final objective is to develop new approaches to the use of air quality and meteorological data for the improvement of life in metropolitan areas. This will involve the integration of existing technologies to enable responses to be made at the most appropriate time and at the most appropriate level. Particular emphasis is placed on forecasting over 24 and 48 hours and providing information to general public.The EMMA project is characterised by:- Integration of existing networks covering a range of air quality and meteorological parameters. This range of air quality and meteorological networks is representative of many European urban areas.- Improved data collection, assessment and forecasting, using common system architectures for monitoring, forecasting and warning networks and models, quality control procedures, expert software systems for the front-end data validation from networks. Introduction of software and system improvements will minimise the time-lag between network measurements and dissemination to the public and media.- Strong orientation to administrations in local environment, transport and health: regions, provinces, municipalities, public hospitals and, most importantly, citizens of metropolitan areas. A User Reference Group will be established with responsibility for establishing objectives and monitoring progress towards their implementation.- Research into economic benefit for administrations and therefore to citizens: integrated architectures and models, and other characteris
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Supporting the identification of policy priorities and recommendations for designing a sustainable track towards circular bio-based systems'.

assistant: **Objectives**

The transition from linear fossil-based systems to circular and bio-based systems represents an opportunity and a suitable pathway for achieving several SDGs. Indeed, circular bio-based systems depict a great opportunity to reconcile sustainable long-term growth with environmental protection through the prudent use of renewable resources for industrial purposes. This needed transition is a complex process, which does not simply require innovative technologies from the supply-side, but also societal transformations based on a multi-actor process. The circular bioeconomy meta-sector may be a good candidate to put forward a new economic model, which requires transformative policies, purposeful innovation, access to finance, risk-taking capacity as well as new and sustainable business models and markets. However, a critical assessment of the environmental, social and economic impacts of the current linear fossil-based economy, as well as of the improvement potential associated with circular bio-based systems, is needed to underpin the identification of policy priorities. Bearing this in mind, SUSTRACK is a three-year project aimed at supporting policymakers in their efforts to develop sustainable pathways to replace fossil and carbon-intensive systems with sustainable circular and bio-based systems (at the EU and regional scale), contributing to achieving the European Green Deal’s objectives. This will be done by: identifying environmental, economic and social limits of a linear carbon-intensive and fossil-based economy; improving existing assessment methodologies; assessing the environmental, social and economic impacts of the EU’s current linear fossil-based economy; comparing multiple transition scenarios focusing on the most carbon-intensive sectors; identifying priorit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Role of intestinal fungal communities in arthritic pathology' (FungArth) under Horizon 2020.

assistant: **Objectives**

The human body is in constant interaction with a complex group of micro-organisms like bacteria, viruses and fungi which populate various body surfaces like our skin, lungs and gut. These organisms generally don’t pose a threat to the host but in contrary have many beneficial functions like stimulating the correct development of our immune system. Until now, research has mainly focused on bacteria, while fungi have largely been overlooked. Enteric fungi represent a significant part of the intestinal microbiota, but their role in human health and disease is poorly characterized. Spondyloarthritis (SpA) is a common immune pathology which causes severe spine and joint inflammation and the lab of Prof. Dirk Elewaut was the first to show a mechanistic link between spondyloarthritis and  intestinal inflammation. Interestingly, anti-fungal immune reponses require Th17 (specific T lymphocytes) activation, an immune arm commonly hyperactivated in arthritic disease. We therefore hypothesize that abberrant antifungal immune responses may be contributing to arthritic pathology. Alternatively, homeostatic fungal-host interactions may be important for both mucosal and systemic immune homeostasis. With this research project, I propose to study in detail the contribution of naturally occurring intestinal fungi to health and SpA development in a multi- disciplinary manner, using elegant genetic mouse models of disease, state-of-the-art tools and technologies  and clinical samples from SpA patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Social and gender inequalities in care: childcare-related policies and parenting practices in the post-Yugoslav countries and the role of policy ideas' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Studies indicate that the middle class disproportionally benefits from social investments in childcare which target both earlychildhood education and care and labour market participation of parents. Still, there is lack of comparative studies whichwould deepen theoretical and policy understanding of social investment approaches applied in various countries and theireffect on childcare-related policies and via that outcomes. This project explores these issues by undertaking the first comparative study of childcare policies in the post-Yugoslav countries (Bosnia-Herzegovina, Croatia, Montenegro, Serbia, Slovenia). It explores the framing and development of entitlements to childcare-related leaves and services, the drivers of the reforms and their outcomes. It is particularly interested in (1) reform potential of the European social investment agenda to affect a redistributive dynamic in childcare and (2) parenting practices of those parents who appear to be redistributive losers of the European social investment agenda (e.g. parents with short-time contracts, unemployed). The data analysed will include national legislation and policy documents and information obtained through expert interviews and interviews withparents. The project tackles the innovative and important topic of social inequalities in childcare, seeking to enhance theunderstanding of the concept of care policy, and adds a new body of empirical evidence to the field of comparative familypolicy, and gender and social inequalities studies. By developing this study at the Department of Social Policy andIntervention at Oxford, the project will benefit from the Department`s multidisciplinary and international perspective andexpertise. For the Department the project will add new knowledge and deepen its regional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Electrical Discharge Machining for enhanced osseointegration and antibacterial capabilities of β-phase Titanium Implant' (EDiMplant).

assistant: **Concept**

Recently, the demand for orthopaedic implants and devices has undertaken rapid growth due to the aging population and its global market is anticipated to reach $66.2B in 2023. To ensure the long-term survival of orthopaedic implants, it is urgent to tailor a multifunctional surface which would simultaneously have enhanced osteogenic and antibacterial properties. Therefore, the aim is to develop a competent surface modification technique which will promote improved osseointegration whilst retaining antimicrobial activity, thus ensuring the life-long performance of implants. A novel surface modification approach will be demonstrated using the specially designed tool electrodes in powder mixed electric discharge machining process for fabrication of modified surface layers exhibiting anti-bacterial and osteogenic characteristics. Exploiting world class facilities at University of Sheffield and a unique multidisciplinary framework; EDiMplant will reach the aim and strengthen the pillars of Horizon 2020. Supervisor(s) with world-leading experience, Dr Gwendolen Reilly, Dr Frederik Claeyssens, Dr Russell Goodall, and Dr Joanna Shepherd, will provide expert training and support to the Fellow in the essential skills inmaterial science, tissue engineering and infection biology, while, Dr Deepak Unune, leading Indian researcher, will bring expertise and novel application of electric discharge machining in surface modifications of implants to the host(s). The high-quality two-way transfer of knowledge required for this project will ensure the research goals of the highest quality are achieved, whilst also presenting a great opportunity to accelerate the academic career of the Fellow. Success would also lead to significant economic and societal impacts for the EU and worldwide, by a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'An innovative toolbox based on Pd-catalysis for protease inhibitor synthesis, applied to the discovery of pan-anti-flaviviral compounds' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Protease inhibitors can potently block the viral replication cycle. In the context of flaviviruses, NS2B-NS3 protease is a promising viral drug target because of its well conserved backbone among flaviviral species, opening the perspective of developing pan-anti-flaviviral NS2B-NS3 inhibitors. All reported NS2B-NS3 inhibitors, however, suffer from low potency and/or poor biopharmaceutical properties. Structural optimization has proven to be slow and challenging, in part because synthetic methodology for fast, chemically versatile and diversity-oriented modification is lacking. To address these challenges, we propose a methodology to assemble protease inhibitors with varying warheads and side chains in just 2 steps from common starting materials, and apply it to the discovery of pan-anti-flaviviral compounds. First, selected amide/carbamate and aldehyde building blocks will be condensed in a reported three-component reaction with phenylsulfinic acid and benzotriazole, delivering individual masked N-acylimines. These will be further submitted to innovative cross-coupling steps, in which warheads will be introduced. Once the methodology is optimized and the scope is determined, at least 10 additional analogues of a known NS2B-NS3 inhibitor will be prepared with variations in the warhead, P1 side chain and P2-P3 moieties will be synthesized. They will be subjected to enzymatic affinity determination, binding kinetics analysis and cellular assays. Experimental data will be used to validate a Molecular Dynamics study of NS2B-NS3 inhibitors. The project is envisaged to deliver significant societal, scientific R&I, and economic impacts by managing flavivirus infections and creating business cases for industrial R&I in Europe.


**Keywords:** Flaviviruses,  Protease inhibitors,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mimicking Bacterial Middle Ear Infection in the Lab' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Bacterial infections in the human body mostly involve biofilms - locally dense populations of bacteria that are extremely difficult to treat with antibiotics. Understanding antibiotic-biofilm interactions is crucial if we are to design better antibiotic treatment regimes to avoid the emergence of antibiotic resistance. In biofilms, bacteria are surrounded by a biopolymer matrix which can inhibit the motion of antibiotic molecules, leading to complex diffusive behaviour. Yet it is not known how these biophysical matrix-antibiotic interactions influence bacterial killing in a spatially complex infection model. Answering this question is the objective of my proposal. I will set up a lab model that mimics Acute Otitis Media -bacterial infection of the middle ear- and I will use advanced microscopy methods to track antibiotic molecules as they interact with bacterial biofilms. I will answer the following questions: A) what is the spatio-temporal distribution of antibiotic molecules in the biofilm? and B) What is  the  effect of biofilm  structure on  the  antibiotic  response,  at the single-cell level? After establishing materials and protocols (objective 1), I will use fluorescence-correlation-spectroscopy (FCS) to characterize the spatial distribution of antibiotic molecules (objective 2). Next, I will use state-of-art 2D STED-FCS method (combination of FCS with stimulated-emission depletion microscopy) to track in unprecedented detail how antibiotics kill individual bacteria within a biofilm (objective 3). Finally, by tracking bacterial growth over long times, I will determine how antibiotic resistance emerges in these spatially complex biofilms (objective 4).


**Keywords:** Bacterial Middle Ear Infection,  Mimicking Antibiotical Therapy in Middle Ear