RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Developing Smart 3D Scaffolds based on Conductive Polymers and Carbon Nanotubes for Cardiac Tissue Engineering' in the context of a Horizon 2020 call.

assistant: **Objectives**

Conductive polymers (CP) appear as promising stimulus-responsing electroactive biomaterial for profileration of cells. CP are versatile materials that can be synthesized in different shapes and morphologies, offering a wide range of application in biosensing, implants, drug delivery and tissue engineering. Carbon Nanotubes (CNTs) have become promising advanced materials and gained increasing importance for applications in nanomedicine, such as diagnosis, disease treatment, imaging, and tissue engineering. CNTs can interact with cells, cross the biological barriers, and modify their functions and biology. More recently, CNTs have become a new tool to specifically interact with the central nervous systems and support tissue repair after brain damage. Take into account of such findings, we hypothesize that CNTs exert functional effects on networks of cardiac myocytes and, in addition, the combination of those two materials will generate an outstanding scaffold for other electroactive cell growth, such as cardiac cells. In my current research, I have developed 3D scaffolds of CNT with a CP skeleton (polypyrrole or PEDOT) and aftewards, the goal of my research and thus the aim of the current proposal is to test such scaffolds for cardiac tissue regeneration. More specific aims are: 1) Adapt already developed smart “scaffold-matrix supports” for heart tissue engineering and test its viability, comprising CNT and conductive polymers.2) In vitro and in vivo studies of healthy and genetically modified cardiomyocites (CM) of neonatal and adult rat hearts to determine the interactions between cells and the smart scaffolds and demonstrate that such devices promote heart cell growth and change their electrical properties.3) Test other carbon nanomaterial scaffolds generated in the h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Smart high-frequency environmental sensor networks for quantifying nonlinear hydrological process dynamics across spatial scales' under Horizon 2020.

assistant: **Concept**

Regulators and industries are challenged by the difficulty to analyse and predict the impact of nonlinear environmental processes on short-term and long-term responses of ecosystems to environmental change. Until very recently, the development of most conventional monitoring, forecasting and prediction tools has been based on the assumption of stationary environmental systems. In the context of global change these tools are increasingly pushed towards and even beyond their design limits (the latter resulting in the first line from the prevailing limitations in spatial and temporal resolution of environmental observations).For this project, we propose a rationale stating that only novel, high-frequency/high-resolution environmental monitoring and predictive modelling will yield new process understanding of ecosystem functioning. Technological progress offers as many opportunities as it triggers challenges: what is needed now are new strategies to generate, manage and analyse BIG DATA at unprecedented spatial and temporal resolution. Innovation can only stand as a synonym for ‘significant positive changes’ if [a] we manage to clearly state the challenges (global change & non-stationarity) and problems (generating and managing high-frequency information) and [b] transform them into solutions, i.e. the quantification and prediction of environmental responses to global change as a prerequisite for designing and implementing adaptation and/or mitigation strategies wherever needed.The timely outcomes of this research project will hence be of great relevance for the scientific community, regulatory agencies, and the private sector.


**Keywords:** Distributed sensor networks, high-frequency environmental sensing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Scalable, Plug & Play and Modular DC Power Systems for low-emission Large Vessels' (ALL-DC-SHIPS).

assistant: **Concept**

The use of fossil fuels and emission of greenhouse gases (GHG) from waterborne must be minimised as fast as possible to reach a climate-neutral society by 2050. A vital prerequisite of the decarbonisation is the rapid growth of low-carbon power sources and energy storage. To achieve this, the efficient integration in the shipboard power system requires the development of high-power components and protections, and more specifically DC-DC power converters and DC switchgear. Albeit DC primary grids have been deployed for several vessels, the secondary grid has remained substantially identical to traditional solution based on AC. There is an opportunity to unlock the capabilities and functionalities of novel components for secondary grids that can improve the safety and the operations on the vessel. These components, integrated with the power converters and the protections of the primary grids, will reduce the risks of blackouts connected to faults and improve the reliability of the power supply.ALL-DC-SHIPS has devised a comprehensive strategy to address the challenges faced by shipowners, systems integrators and ship operators that includes:1)development of new modular power converters with wide bandgap devices for primary DC grids2)high-density power converters for secondary DC grids3)innovative DC protection systems for primary and secondary DC grids4)implementation of advanced algorithms for real-time ship energy management5)rigorous testing and validation methodologies for the vessel demonstrator6)providing recommendations for relevant use cases above 5,000 GT.ALL-DC-SHIPS will contribute to enable low-emission waterborne transport and technology transition for a resilient and sustainable future of the maritime sector.


**Keywords:** DC power networks, power control
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Maximizing the use of a first clinically viable MYC inhibitor' (MYCiMAX) under Horizon Europe.

assistant: **Objectives**

Even though the MYC oncogene is a “most-wanted” target in cancer therapy, no MYC inhibitor has yet reached clinical approval. The applicant has developed Omomyc, the first MYC-inhibiting mini-protein to have successfully completed a Phase Ia clinical trial. The goal of this proposal is to maximise the use of this compound, as both a therapeutic and study tool, opening new lines of research in different aspects of MYC biology.To start with, since Omomyc cannot efficiently cross the blood brain barrier, excluding it from use in brain malignancies or brain metastases, in Aim 1, we propose to validate its efficacy when delivered intracranially by different means, including osmotic pumps and hydrogels, as well as to test its delivery by intracarotid injection, in glioblastoma and brain metastases.Then, in Aim 2 and 3, we will explore its combination with personalized medicine, namely PARPi and KRASi, respectively. These 2 aims are derived from two pillars of MYC biology: its role in DNA damage response and the paradigm of oncogene cooperation. Aim 2 will allow us to shed light on the role of MYC in homologous recombination and resistance to PARPi, while Aim 3 will deliver on the molecular mechanisms underlying the cooperation of RAS and MYC in multiple tumour types, where their combined inhibition could represent an unprecedented therapeutic opportunity.Finally, Aim 4 will focus on the characterisation of cancers such as Small Cell Lung Cancer and Gastrointestinal Stromal Tumours that have the peculiarity of being defective for MAX – MYC’s natural partner – but that recapitulate a MYC-dependent tumour phenotype, likely driven by other members of the MYC network, whose function could also be hindered by Omomyc treatment.Notably, each of the aims explores new aspects of MYC bi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The on-board railway track & vehicle monitoring system'.

assistant: **Objectives**

Detection and rectification of the main accident precursors (broken rails and track buckles) are one of the major issues for all players in railway systems that operate 24/7, at increasing speed, and with a growing number of users. Current inspection tools used for railway monitoring such as laboratory vehicles, self-powered auscultation trains and manually pushed carts require disruption of the railway traffic and are expensive.Additionally, comfort is an essential factor besides maintenance in the competition between railway and other means of transportation. Ride comfort is a complex notion that represents an important criterion when examining the dynamics of railway vehicles and needs to be considered for their modelling and behaviour evaluation.vmRail is the first reliable and cost affordable technology able to combine sensor networks, computer simulation and signal processing to evaluate the state of railways and rolling stocks by comparing track geometry irregularities data and wear & fatigue evolution in real time. Therefore, vmRail simultaneously improves vehicle and track maintenance operations, ride safety, and passenger comfort.  With fleets and infrastructures being operated for 30 to 50 years and maintenance accounting for ~50 % of overall cost, the main goal of railway and underground operators is to cost-efficiently increase fleet availability and reliability. Railway and underground operators will benefit of using vmRail by avoiding unnecessary replacements and results in less network disruption due to unplanned/planned maintenance. Moreover, our technology is up to 90% less expensive than current laboratory trains since is based on computing vision, accelerometers and simulations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Meso and Sub-mesoscale Physico-biogeochemical Dynamics in a Coastal NW Mediterranean Sea: Quantifying and Understanding Ecosystem Structure and Transport' (SEAQUEST).

assistant: **Concept**

Shelf and coastal regions are at the interface between continents (impacted by human activities) and the open ocean (the main regulator of our planet’s climate and its biogeochemical cycles). The shelf-sea carbon pump largely relies on lateral transport to remove atmospheric CO2 from the ventilated surface waters and sequester it at depth. A good understanding of the physical transport processes in coastal regions and their impact on the ecosystem dynamics is therefore not only important for future climate predictions but also has a more immediate relevance (e.g., knowledge of local transport is necessary for the creation of marine protected areas, the management of spills, or the mitigation of harmful blooms events, etc.).SeaQUEST will study the horizontal transport and cross-shelf exchange processes including their effect on the biogeochemistry in the coastal zone around the Gulf of Lion (GoL) off the French Mediterranea coast, a highly productive area and important feeding ground for fish, birds, and mammals, both resident and migratory. The main goal of SeaQUEST is to examine the role of the Northern Current as a physical barrier to cross-shelf transport and the effect of its seasonal variability on the local biogeochemistry and plankton dynamics at meso- and sub-mesoscales. This will be achieved through a highly interdisciplinary approach employing a range of methods and data (numerical simulations, in situ and satellite observations). SeaQUEST will provide new insights into the ecosystem functioning and biological-physical interactions in a highly productive and economically important coastal area which is also one of the main tourist destinations worldwide. The results will therefore be of broad relevance to a variety of stakeholders including decision makers and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Covalent Organic Framework Membrane Reactors for Full-Volume Active Electrodes in CO2 Electrolysis' (COFActiveCO2).

assistant: **Concept**

The diffusion of particles such as electrons, photons, ions, and molecules in substances represents a basic phenomenon in the universe. By manual control of the diffusion of these particles, a directional transport can be achieved, enabling the invention of electricity, fiber-optic communication and desalination. The pursuit of more powerful control over transporting processes constitutes a foundation for technology evolution. This is exactly what this project aims to do.The co-transport of multiple species in a single substance is typically prohibited in nature. This because different species have their own preferable transport environments, which are markedly disparate from one another. Optimizing the transport environment for different species in one material is therefore a great challenge, and the efforts of doing so often leads to undesired outcomes, such as trade-offs or even annihilation effects. However, the co-transport of multiple species is a necessity in technologies like electrolysis. Thus, a fundamental innovation in material science is needed to address the problem of simultaneous diffusions.In COFActiveCO2, I will use reticular chemistry to construct macromolecular type framework materials with compartmentalized multi-channels for mixed transport. The project will realize unprecedentedly control over the simultaneous transport of electrons, ions and molecules, to achieve intercalated nano-flows at high flux. As a result, a large contact between hybrid nano-flows will greatly facilitate the chemical kinetics in electrochemical processes. The implementation of membrane reactors with such design will enable significant upgrade in the electrochemical conversion efficiency of working electrodes in CO2 electrolysis technology, thus paving the way for a sustain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Procurement Innovation for Cloud Services in Europe' in the context of a Horizon 2020 call.

assistant: **Objectives**

The PICSE Procurers’ Platform will give access to a unique repository of information supporting the move from outright purchase to ‘pay-per-usage’ made possible by the arrival of cloud computing. It builds on the Helix Nebula collaboration between supply and demand of which the three PICSE partners are key members, including the H-N coordinator, CERN. It addresses the fragmented landscape of inconsistent technical approaches and disjointed managerial structures that prevent delivery of a production-quality cloud computing e-infrastructure.PICSE will engage with cloud service providers, their customers and procurement professionals over a crucial period as Europe’s Cloud Strategy comes to fruition and several large multinational procurements (including PPIs and PCPs) take place. The project will provide a focal point avoiding duplication of efforts to identify, analyse, publicise and harmonise opportunities for shared procurement, including a direct response to the ECP Trusted Cloud Europe science use case, addressing cross-border procurement. PICSE will resolve key financial and legal constraints impacting business development and procurement and provide a range of best practices that address those barriers from both private and public sectors, including the research domain, in and beyond Europe. It will set out a realistic roadmap of future procurement based on the levels of ambition for adoption of cloud services over the next five years. This reflects the European Cloud Computing Strategy which calls for a framework of standards to give procurers confidence that they have met their compliance obligations and that they are getting an appropriate solution to meet their needs.


**Keywords:** Cloud Services, Public Research Sector, Best Practice, Roadmap, International
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'EOSC Track: Implementing the European Open Science monitoring mechanism' to be submitted under Horizon Europe.

assistant: **Abstract**

EOSC Track will develop and operate the European Open Science Observatory, a policy intelligence tool that will monitor policies, investments, digital research outputs, skills and infrastructure capacities related to the Open Science and the European Open Science Cloud (EOSC). Its mission is to simplify and streamline monitoring in the European Open Science ecosystem, to bring a common understanding on how to collect and interpret data appropriate for monitoring, as well as to assist policymakers and research executives across Europe in understanding, shaping, and aligning Open Science and related policies and their implementation.Starting from the current EOSC Observatory developed during the EOSC Future project (TRL7), EOSC Track will transform the service into TRL9, making it an open, secure and trusted platform to serve as the go-to place for Open Science monitoring Europe. It will enhance it with features to improve usability, engagement and collaboration: automate data ingestion from trusted sources such as the OpenAIRE Graph, incorporate collaborative editing and validation of data, add interactive navigation and search, visualisations. It will complement with the EOS Resources Registry which will serve as a learning tool by including narratives from experts to demonstrate the internal processes towards the OS implementation in a country, and stories for impact or best practice.EOSC Track will explore the sustainability of the EOS Observatory by fostering a co-design process with the EOSC tripartite partnership and other interested stakeholders. The objective is to align various monitoring initiatives, offer practical assistance in data collection, and generate 360o reports to establish a de-facto hub for all information around monitoring Open Science and EOSC in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Deciphering the newly discovered branchial cavity immune surveillance system to protect fish against infectious diseases in aquaculture.' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The sustainability of aquaculture, an important food source for human, is severely challenged by infectious diseases. Unfortunately, the development of new therapies and vaccines is hindered by our incomplete understanding of the fish immune system. The lack of knowledge of the mechanisms governing immune responses in the branchial cavity is particularly alarming considering that it represents a main port of entry for pathogens and is involved in many pathologies affecting farmed fish. Recent findings of new lymphoid tissues, bound together by a previously unknown tonsil-like organ inside an even larger lymphoid network revealed the branchial cavity as an unsuspected important region of the fish immune system. The main objective of this project is to characterize this newly discovered branchial cavity immune surveillance system to harness its potential against infectious diseases in aquaculture. Toward this goal, the project will take advantage of the zebrafish model to achieve the following objectives: 1) Characterize the newly discovered lymphoid tissues and tonsil-like organ. 2) Decipher the rules of antigen sampling and transport in the branchial cavity. 3) Characterize the development of the branchial cavity lymphoid architecture. 4) Decipher the roles of the branchial cavity immune surveillance system in immune responses to infection and vaccines. In a comparative effort, the project will then study the branchial cavity immune system in Atlantic salmon and other fish species relevant for aquaculture. The methodology will combine sophisticated immunohistology, nanotechnologies, state-of-the-art transcriptomic analysis, antibody-assays, and advanced 3D microscopy. The project will progress far beyond the current knowledge in fish immunology, which could drastically