RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Science and Technology - Europe Africa Project' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The primary objective of the project is the strengthening of science and technology (S&T) co-operation between African scientists and between African and European scientists.This objective is endorsed by both Africa and the European Union (EU) respectively in Africa's Science and Technology Consolidated Plan of Action of NEPAD (New Partnership for Africa's Development) and in the recently adopted EU Strategy for Africa.The Science and Technology - European African Project (ST-EAP) aims to heighten awareness of European funding mechanisms and S&T co-operative instruments that support the creation of African/European consortia. In particular ST-EAP seeks to create an increased awareness of the role of the Framework Programmes. The tools intended to address these goals include workshops, conferences, dialogue with National Contact Points, the Informal Group of Liaison Officers and the S&T community of Africa.This will include focussed presentations, a website (including partnering and funding databases) and material highlighting Africa's S&T expertise. ST-EAP will seek mechanisms to facilitate greater EU Africa/NEPAD collaboration, and provide a greater input into future Framework Programmes and proposals for sustainability and growth of the African and EU S&T communities.This will also promote the internationalising of the European Research Area (ERA) by contributing to the international dimension requirements for integrating and strengthening the ERA and derive benefit for the people of the participating countries through identifying and addressing S&T priorities that provide opportunities for increased economic growth, and improved quality of life.ST-EAP is coordinated by South Africa's CSIR (Council for Scientific and Industrial Research) and the AAS (African Academy o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Transgenic models for HBV related hepatocellular carcinoma'.

assistant: **Innovation**

Objectives:Genetic dissection of the HBV pX transactivation, apoptotic and tumor promoting function. Isolation and characterization of mutated HBV pX proteins from HBV patients. Generation of transgenic animals, expressing wt or mutated HBV pX in liver or in mammary gland epithelial cells.Brief description:The HBV encoded pX protein plays a major role in the development of hepatocellular carcinoma by either modulating the susceptibility of the infected cells to apoptosis or by inducing uncontrolled cell growth. Although hepatocellular carcinoma is the most prevalent human cancer, only a minority of patients suffering from chronic viral hepatitis undergoes neoplastic transformation indicating that pX synthesis per se is not sufficient to induce tumor formation. Cell transformation may require either activation of cellular oncogenes or alteration of the expression level of cellular genes involved in the regulation of apoptotic cell death of hepatocytes. In addition the HBV undergoes a high rate of spontaneous mutations in chronically infected individuals. Thus the possibility exists that transformation may be linked to the emergence of mutant pX proteins more than to the expression of the wild type pX protein. In the concerted action, both hypothesis will be tested in transgenic animals and in tissue culture cell lines. The identification of co-oncogenic events will be pursued by pairing wild type HBV-X mice either with transgenic animals expressing known oncogenes to generate double transgenic mice or with knock-out mice lacking key modulators of apoptotic cell death. To access the role of pX variability the pX gene will be cloned from a panel of HBV patients with different clinical outcome. Naturally occurring mutants will be tested in vitro to select functionally relev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Benchmarking of Benchmarking', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The study is split up in five topics. The first topic is a basic study on the definition of benchmarking. The other topics will be developed on the basis of this conceptual definition.The criteria for good benchmarking procedures will be evaluated. An inventory will be made of the existing benchmark systems in transport in Europe. The possibilities of technical improvement for benchmarking will be examined. Based on the research study and the communication with the thematic network, a guideline for benchmarking will be set up.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Contribution de la TSP-1 dans l hémostase, l" angiogénèse et la dissémination métastatique"' (2002-2006).

assistant: **Innovation**

As a newly recruited scientist my project aims at validate the strategy consisting in the neutralization of thrombospondin-1 (TSP-1) as a pharmacological approach for the treatment of thrombosis, and for the development of an anti-cancer therapy based on t he properties of TSP-1 in metastasis and angiogenesis. In close collaboration with my postdoctoral host, we will study the contribution of TSP-1 in platelet recruitment onto vessel wall, in vivo, with the use of TSP-1 null mice in models of inflammation an d thrombosis monitored in situ by intravital videomicroscopy; bone marrow transplantation between wild type and TSP-1-/- mice; in vitro, with the identification of cell-receptors of TSP-1 important for platelet adhesion and aggregation. Platelets are favouring metastasis by participating in tumour cells adhesion and extravasations through the vessel wall. Since TSP-1 is a major platelet component, we will investigate its role in platelets/tumour cells/endothelium interactions.The work will be conduced in WT and TSP-1-/- mice; by tracking platelets/tumour cells conjugates interacting with the endothelium using intra vital microscopy. Because cancer is often associated with inflammation and thrombosis, which, in turn, favour metastasis, we will use in vivo and in vitro models to study the role of TSP-1 in these processes TSP-1 is an anti-angionegic protein. However the N-ter TSP-1 fragment is pro-angiogenic. Using both in vitro and in vivo models, we will evaluate whether the production of the fragment correlates with the extent of angiogenesis, and whether its neutralization is an efficient anti-angiogenic strategy for anti-cancer therapy. I initiated the creation in the reintegration host, of a structure operating the in vivo models that I developed during my pos t-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sustainable livelihoods in southeast asia: a grassroots-informed approach to food security' in the context of a Fifth Framework call.

assistant: **Objectives**

The project aims to enhance food security for marginalised rural, urban and peri - urban groups in SE Asia by incorporating popular coping strategies, identified through in-depth grassroots research and macro-micro policy analysis. The project is congruent with recent theoretical and practical challenges to the top-down development orthodoxy, and is compatible with the UNDPTMs Sustainable Livelihoods approach. The project will explore, identify, fine-tune and integrate into future policy initiatives popular strategies for coping with food insecurity/insufficiency in Thailand, Vietnam and the Lao PDR. The Asian economic crisis, global and regional integration, and post-socialist economic reform provide a back-drop to important elements of the research. The project is designed to enhance institutional development and capacity-building in SE Asia by strengthening Europe-Asia policy dialogue, and by disseminating and informing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'BIO-mimetic structures for LOComotion in the Human body' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The objectives of the project are to understand motion and perception systems of lower animal forms, such as parasites, worms, insects and even snakes and eels, and to design and fabricate bio-inspired mini- and micro-machines able to navigate in tortuous and difficult to access cavities, in particular, in the human body. This idea originates from the medical need to develop more powerful tools for micro-endoscopy, one of the most challenging and useful frontiers of modern medicine.The most significant objectives which represent parallel and complementary results are: the increasing of knowledge in the field of biomechanics and neural control; the definition of biologically inspired design paradigms; the development of innovative hybrid manufacturing technologies.The objectives of the project are to understand motion and perception systems of lower animal forms, such as parasites, worms, insects and even snakes and eels, and to design and fabricate bio-inspired mini- and micro-machines able to navigate in tortuous and difficult to access cavities, in particular, in the human body. This idea originates from the medical need to develop more powerful tools for micro-endoscopy, one of the most challenging and useful frontiers of modern medicine.The most significant objectives which represent parallel and complementary results are: the increasing of knowledge in the field of biomechanics and neural control; the definition of biologically inspired design paradigms; the development of innovative hybrid manufacturing technologies.DESCRIPTION OF WORKThe first step in the project will be to study the locomotion mechanisms used by animals which move in a wet environment containing large amounts of solid and semi-solid material. In order to understand better how to gain purchase on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Making a yeast-based candidate vaccine against Porcine Epidemic Diarrhea Virus  (PEDV)' (PEDV).

assistant: **Innovation**

PIGYVAX aims to create pig vaccine candidates against PEDV, a pathogen of swine causing significant challenges to the swine industry globally. This project will utilize yeast-based vaccine carrying nanoparticles of measles ribonucleoprotein (RNP) fused with PEDV spike protein (S1).  The multimerization of monomeric S1 antigen through RNP will increase immunogenicity due to better recognition of antigen presenting cells. As the yeast delivery system has strong auto-adjuvant properties, the vaccine does not require complementation with accessory adjuvant, which reduces the cost of vaccine production. Moreover, P. pastoris yeast, commonly present on fruits, is a certified safe microorganism for animal feeds rendering it a most practical and convenient way to deliver vaccines to large-scale farms. Therefore, we aim to use this vaccine platform to express S1 antigen of PEDV and deliver it orally to stimulate a protective immune response against PEDV in sows, which will be passively transferred to fully protect piglets from succumbing to the disease. In this project, Dr. Phanramphoei Frantz will utilize her knowledge on pathogenesis of PEDV and the yeast-RNP platform while gaining expertise on vaccine study and development from the host institute. This will initiate a successful collaboration project between Institut Pasteur and BIOTEC (Thailand) to where the experienced researcher will return after the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'An eco-friendly, Integrated Facility and Energy Management Platform for continuous reduction of infrastructure operating cost, driven by AI.' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Commercial buildings are responsible for approximately 40% of energy consumption and 36% of CO2 emissions in the EU alone. With the use of better and energy efficient Facility Management Systems there is a potential of reducing the EU’s total energy consumption up to 6% and lowering greenhouse emissions by about 5% . Currently there is a lack of an intelligent and context-aware BMS which can monitor as well as manage the buildings efficiently in real time. However the use of current Building Management System can increase the maintenance cost up to €100,000 per building, lacks the integration of advanced data analytics as well as AI to identify risk conditions for people and building equipment, have limited real-time response capabilities and are vulnerable to privacy and data breach attacks. Yodiwo FEMP is an IoT based platform which aims to optimize facility management operations and improve energy efficiency of building equipment. Yodiwo FEMP uses AI/ML algorithms and advanced data analytics to provide predictive maintenance, safety and device optimization, automation to increase energy efficiency and increase the comfort level of occupants. During the phase 1 project, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted. The innovation project will allow for the finalization of the Yodiwo FEMP platform and the scale-up the platform capability with end-users and performing in-field demonstration with initial customers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Protein Nanosheet-Stabilised Emulsions for Next Generation Biomanufacturing', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The large scale expansion of adherent cells, which underpins the production of stem cells for regenerative medicine and the manufacturing of complex biotherapeutics (e.g. exosomes and vaccines) remains challenging and a key hurdle to the accessibility of associated therapies. Indeed, the expansion of adherent stem cells and adherent cell lines for bioproduction relies on culture on solid microcarriers that remain difficult to process and significantly add to costs. Cell adhesion to solid substrates and associated mechanotransduction is thought to be essential to mediate key processes regulating the production of biotherapeutics, such as exosome secretion and protein glycosylation. However, we recently demonstrated that liquid substrates, such as emulsion microdroplets, can support cell adhesion and promote the retention of a normal adherent phenotype. We showed that this process is mediated by the self-assembly of mechanically strong protein nanosheets at corresponding liquid-liquid interfaces. This project will demonstrate the scale up of emulsion-based biomanufacturing platforms. We will scale up (L scale) bio-emulsions based on protein nanosheets that promote cell adhesion and display suitable interfacial mechanics, from affordable protein sources. We will demonstrate the compatibility of such systems with bioreactors routinely used in the field, for the scale up of adherent stem cells production, and that of adherent cell lines for biotherapeutics production (exosomes and vaccines). We will establish further IP and a commercialisation strategy with identified partners to translate our technology in the field of biomanufacturing. We propose that bio-emulsions for the culture of adherent cells will bring a step change to the field of biomanufacturing, enabling to borr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Capacity for Copernicus REDD+ and Forest Monitoring Services' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Efforts to monitor and map changes of forest areas using Earth Observation (EO) technologies to support decision making in reversing deforestation/degradation has been increasing in the past decade. This has especially gained momentum due to key developments for example in the United Nations Convention on Climate Change (UNFCCC) policy process related to countries reducing emissions from deforestation and degradation (REDD) which requires an assessment of national historical and projected deforestation/degradation rates and statistics. The advent of the European Copernicus Programme’s Sentinel data with their high spatial resolution and revisit time at global, regional and national levels provides an unprecedented volume of data for improved forest monitoring which should be exploited by the European science and EO industry communities. The current Project aims to implement a co-ordination and consolidation of the existing European Capacity for EO based Forest Monitoring with relevant stakeholders, International Agencies, Research Community and Private Sector. A key outcome of the Project would then be a proposed framework for a Copernicus REDD+ Service which can make use of the planned Copernicus Data and Information Access Services (C-DIAS) Platform for improving EO data and product accessibility and functionality to end Users. Furthermore the identification of infrastructural and research gaps for EO Forest Monitoring on different scales (global to local) will result in the definition of future R&D Programmes addressing key gaps and priorities.


**Keywords:** UNFCCC REDD+
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mesoscopic models for propagation in biology' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

According to biologists, there is a need for quantitative models that are able to cope with the complexity of problems arising in the field of life sciences. Here, complexity refers to the interplay between various scales that are not clearly separate. The great challenge of the MESOPROBIO project is to analyse complex PDE models for biological propagation phenomena at the mesoscale. By analogy with the kinetic theory of gases, this is an intermediate level of description between the microscale (individual-based models) and the macroscale (parabolic reaction-transport-diffusion equations). The specific feature common to all the models involved in the project is the local heterogeneity with respect to a structure variable (velocity, phenotypical trait, age) which requires new mathematical methods. I propose to push analysis beyond classical upscaling arguments and to track the local heterogeneity all along the analysis.The biological applications are: concentration waves of bacteria, evolutionary aspects of structured populations (with respect to dispersal ability or life-history traits), and anomalous diffusion. The mathematical challenges are: multiscale analysis of PDE having different properties in different directions of the phase space, including nonlocal terms (scattering, competition), and possibly lacking basic features of reaction-diffusion equations such as the maximum principle. The outcomes are: travelling waves, accelerating fronts, approximation of geometric optics, nonlocal Hamilton-Jacobi equations, optimal foraging strategies and evolutionary dynamics of phenotypical traits. Emphasis will be placed on quantitative results with strong feedback towards biology.The project will be conducted in Lyon, a French hub for mathematical biology and hyperbolic equa