RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Directly reprogrammed renal cells for targeted medicine' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The global incidence of kidney disease is on the rise, but little progress has been made to develop novel therapies or preventative measures.New methods to generated renal tissue in vitro hold great promise for regenerative medicine and the prospect of organ replacement. Most of the strategies employed differentiate induced pluripotent stem cells (iPSCs) into kidney organoids, which can be derived from patient tissue. Direct reprogramming is an alternative approach to convert one cell type into another using cell fate specifying transcription factors. We were the first to develop a method to directly reprogram mouse and human fibroblasts to kidney cells (induced renal tubular epithelial cells - iRECs) without the need for pluripotent cells. Morphological, transcriptomic and functional analyses found that directly reprogrammed iRECs are remarkably similar to native renal tubular cells. Direct reprogramming is fast, technically simple and scalable.This proposal aims to establish direct reprogramming in nephrology and develop novel in vitro models for kidney diseases that primarily affect the renal tubules. We will unravel the mechanics of how only four transcription factors can change the morphology and function of fibroblasts towards a renal tubule cell identity. These insights will be used to identify alternative routes to directly reprogram tubule cells with increased efficiency and accuracy. We will identify cell type specifying factors for reprogramming of tubular segment specific cell types. Finally, we will use of reprogrammed kidney cells to establish new in vitro models for autosomal dominant polycystic kidney disease and nephronophthisis.Direct reprogramming holds enormous potential to deliver patient specific disease models for diagnostic and therapeutic applic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Broadband cloaking and shielding of elastic waves in solids.' (METACLOAK).

assistant: **Concept**

In this project we aim to develop the theory to underpin the optimal design of metamaterial devices.  We will test the theory by building a metamaterial cloak which surpasses current models in its combination of elastic wave protection and cloaking capacities at frequency band much larger (~1 kHz).The design of the cloak is based on a novel metamaterial that I have co-developed, consisting of a cluster of closely spaced sub-wavelength resonators fixed to a thin plate where flexural waves propagate.  The effective properties of this cloak are generated by local resonance effects and they include, besides large band gaps, negative diffraction (refraction) index, sub-wavelength energy focusing and broad scalability in the sound and infrasound frequency range. Contrary to other studies, it does not require an unrealistic composite material to be realised, or a periodic arrangement of resonant elements and hence it should have real practical impact. Two innovative applications concerning control of mechanical vibrations, and seismology are proposed.  To refine the modelling, detailed numerical simulations and development of optimisation schemes are required: this will benefit enormously from interaction with several groupings at Imperial College (in Physics, Mathematics and Mechanical Engineering), highly active in elastic waves and metamaterials, that have very relevant expertise. 3D numerical simulations giving quantitative analysis of the cloak properties and performance will guide the construction of laboratory models for experimental validation. The distribution and the structure of the resonators (vertical beams with nominal section much smaller than the wavelength) are the main parameters governing the performances of the cloak. The optimisation strategies that will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Risk reduction for Building Energy Efficiency investments'.

assistant: **Concept**

EEnvest aims at supporting investors´ decision making process by translating building’s energy efficiency technical requirements into economic indicators. These indicators are in turn used to evaluate financial risks associated with deep renovation investment and to include non-energy benefits in asset evaluation models. EEnvest will allow the financial sector to match the EE investments demand and offer for commercial office buildings located in Italy and Spain. EEnvest will increase financers’, investors’, owners’ and users’ mutual trust, by identifying, quantifying and mitigating technical risks associated to those investments as well as by reducing the cost of credit for lenders through targeted risk reduction actions.  EEnvest will develop effective evaluation methods for the technical/financial risk correlation by categorising a number of major technical risks and quantifying their impact on investors´ confidence. Those risks will be i) evaluated exploiting existing databases on building energy efficiency (e.g. DEEP database of Energy Efficincy Financial Institutions Group), ii) organized into investor friendly bechmark track record and iii) transferred on a web-based platform through secured blockchain networks The investment demand and offer will be supported by the EEnvest - search&match investment evaluation web-based platform, integrating building stock evaluation data, both from the technical and the financial side. EEnvest approach will be replicable in more countries and business cases thanks to the standardization of technical/financial due diligence framework for energy efficiency renovation of buildings and to the search&match web-based platform allowing deep renovation investments to be more appealing on the financial market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Lund laser centre' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Description:The Lund Laser Centre (LLC) is the largest unit in the Nordic countries within the field of lasers, optics and spectroscopy. Research is performed in basic atomic, molecular and chemical physics and includes applications to the energy, environmental, medical and information technology fields. The LLC is characterized by its interdisciplinary nature, fostering a strong exchange of ideas, techniques and resources. The Centre has extraordinary resources in terms of scientific expertise, advanced laser systems (=30 major systems, including a 10 Hz terawatt laser), detection and auxiliary equipment. Experimental techniques range from CW high-resolution spectroscopy to ultra-fast (fs) spectroscopy. The accessible spectral region ranges from the IR to the X-ray region. Research includes ultra-high intensity laser/matter interaction, atomic and molecular laser spectroscopy, chemical dynamics, combustion diagnostics, laser spectroscopy of the atmosphere, hydrosphere and vegetation, and spectroscopic diagnostics in biology and medicine. LLC is a partner of a cluster of collaborating laser centres including, in addition to LLC, LENS (Florence, Italy), LIF-ENSTA-X (Palaiseau, France), ULF-FORTH (Heraklion, Greece), MBI (Berlin, Germany) and LCVU (Amsterdam, The Netherlands).Application:Interested researchers are advised to contact the project manager of any of the cluster installations to get information and assistance on the application procedure. Instructions and forms to submit a research porposal may be obtained from the WWW-Server of the LIMANS-III-Cluster at http://tmr.mbi-berlin.de or http://limans3.mbiberlin.de. A link to this URL is contained in each of the participating installations' Web-sites. Proposals will be selected by a panel consisting of at least 20 i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'DOMESTIC INTERACTIVE TELEMATIC EDUCATION AND LEARNING' (DOMITEL).

assistant: **Concept**

DOMITEL is aimed at a telematics environment for learners at home, using interactive cable television. Two-way cable TV will be demonstrated as the basic infrastructure, together with others offering a range of interactivity, from one-way video with interactive teletext to full two-way video allowing for multimedia applications and videophony. Initial project applications will include courses for immigrants to The Netherlands, English as a second language and professional development for unemployed graduate engineers. The project is expected to also result in a home learning specifications manual for planning and implementing interactive cable television..DOMITEL, DOMestic Interactive Telematic Education and Learning aims to develop and to demonstrate a supporting telematic learning environment for home learners, using interactive cable television.The demonstrator that will be developed will use two-way cable television (CATV) as the basic infrastructure in conjunction with other technologies and infrastructures offering a range of interactivity from one-way video with interactive teletext through fully two-way video allowing for multimedia applications and videphony.During the first two years of the project several applications will be demonstrated.In Amsterdam (NL) a 'inburgerings'course for new immigrants will use video-on-demand and interactive teletext. In Dunblin/Knocklyn (IE) a 'Return to Learning Course' will combine video delivery with interactivity via a LAN overlay on the cable and an educational interface tool on the Internet called WEST.In Birmingham (UK) an 'English as a Second Language Course' for women of Asian extraction will include live two-way video feedback made available at homes and via community access points.In Lahti (FI) unemployed graduate eng
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Establishing design rules for creating collagen-like materials with specific mechanical stability and response (COLMEC)'.

assistant: **Concept**

Every day, our bodies endure myriad mechanical forces that influence proteins, especially collagen, at the molecular level. COLMEC aims to use collagen as a model to uncover the nuances of protein mechanochemistry. A central aspect of this research is deciphering how collagen's evolutionary adaptations influence its response to forces, especially in contexts of aging and disease. This pursuit is split into three distinct objectives: (1) investigating the coevolution of collagen's amino acid residues to decode its response to tensile forces; (2) delving into the role of metal ions in collagen crosslinking, drawing parallels with natural phenomena such as the resilience of mussel byssus; and (3) probing the mechanisms of force propagation within collagen's varied structures. Merging bioinformatics, computational biophysics, and materials science, COLMEC's interdisciplinary approach illuminates how evolution shapes protein defenses against mechanical strains. This knowledge is pivotal in establishing design rules for crafting synthetic collagen-like materials with tailored mechanical stability and response, bridging evolutionary insights with innovative material design.


**Keywords:** mechanically active proteins, mechanochemistry, collagen, mechanoradicals, protein coevolution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Reconsidering Niels Bohr's Interpretation of Quantum Physics'.

assistant: **Objectives**

This project aims at a deeper understanding of Niels Bohr’s philosophical thought on quantum mechanics.  Bohr was one of the creators of what is known as the old quantum theory, developed in the years 1913–1925, and one of the most influential interpreters of the new quantum theory, which was developed in 1925–1927 and is the version accepted by physicists today.Though influential, Bohr’s thoughts on quantum mechanics are notoriously difficult to understand. The current project will shed light on Bohr’s thought by viewing it within a framework informed by the philosophy of symbolic forms of the neo-Kantian philosopher Ernst Cassirer, and the revision of Kantianism due to Michael Friedman, which is also inspired by Cassirer, although alternative views also shall be considered. The chief difference between this revised Kantianism and the philosophy of Kant is that, whereas for Kant the conditions for the possibility of experience, through which we make sense of talk of objects of experience are fixed and immutable, in the revised version they develop along with the development of science.The core of the project will involve an examination of the status of the correspondence principle, a crucial ingredient in the transformation of the old quantum theory to the new quantum theory. The correspondence principle requires agreement, in some respect, between classical mechanics and quantum mechanics in the limit of large quantum numbers. The result of the project will not only be a deeper understanding of Bohr’s thought and the development of quantum mechanics; there will be broader implications for understanding the development of science.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'CAMAP: Computer Aided Modeling for Astrophysical Plasmas' to be submitted under Seventh Framework.

assistant: **Abstract**

This project will be aimed at obtaining a deeper insight into the physical processes taking place in astrophysical magnetized plasmas. To study these scenarios I will employ different numerical codes as virtual tools that enable me to experiment on computers (virtual labs) with distinct initial and boundary conditions. Among the kind of sources I am interested to consider, I outline the following: Gamma-Ray Bursts (GRBs), extragalactic jets from Active Galactic Nuclei (AGN), magnetars and collapsing stellar cores. A number of important questions are still open regarding the fundamental properties of these astrophysical sources (e.g., collimation, acceleration mechanism, composition, high-energy emission, gravitational wave signature). Additionally, there are analytical issues on the formalism in relativistic dynamics not resolved yet, e.g., the covariant extension of resistive magnetohydrodynamics (MHD). All these problems are so complex that only a computational approach is feasible. I plan to study them by means of relativistic and Newtonian MHD numerical simulations. A principal focus of the project will be to assess the relevance of magnetic fields in the generation, collimation and ulterior propagation of relativistic jets from the GRB progenitors and from AGNs. More generally, I will pursue the goal of understanding the process of amplification of seed magnetic fields until they become dynamically relevant, e.g., using semi-global and local simulations of representative boxes of collapsed stellar cores. A big emphasis will be put on including all the relevant microphysics (e.g. neutrino physics), non-ideal effects (particularly, reconnection physics) and energy transport due to neutrinos and photons to account for the relevant processes in the former systems. A mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Low cost technologies and traditional ingredients for the production of affordable, nutritionally correct foods improving health in population groups at risk of poverty' to be submitted under Seventh Framework.

assistant: **Abstract**

According to 2007 Eurostat statistics, there is a robust need to better understanding the nutritional existing barriers to healthy nutrition of 79 million EU-27 citizens at-risk-of-poverty. These European subclusters and ethnic populations have in common low purchasing power, limited education and the highest risk of diet-related diseases due to sub-optimal nutrition. CHANCE project will i) define an innovative strategy based on a socio-economic study of the composition of the most significant EU populations at-risk-of-poverty and ii) verify the relative existing nutritional deficiency via a holistic approach ensured by metabonomics investigations correlating the non-healthy diet to real metabolism alterations. CHANCE intends to adopt a new multidisciplinary approach, leading to nutritional strategies for the prevention of malnutrition in population groups at risk of poverty. CHANCE aims at considering a new health value-added diet as a whole by developing food products which could act in concert. The synergic collaboration of nutritionists, food chemists, economists and technologists allow a robust strategy to by pass all barriers to healthy nutrition by the lab-scale development of affordable but nutritionally-rich food products, new packaging and portioning. The R&D activities planned in the enlarged European Union will facilitate a proactive collaboration among food research centers and food processing and packaging SMEs that will be further transferred with the generated foreground. During the processing of food products, nutrient content and stability will be assessed, then the whole technology process will get the influential support of a CEN Workshop Agreement, drafted within CEN (the European Committee for Standardization) in order to help ensuring consumers wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Novel dental implant maintenance instrument; Production scaling up and European market expansion'.

assistant: **Innovation**

Peri-implant disease (Mucositis and peri-implantitis) is a major and growing clinical problem in odontology, affecting 20-40mill. patients in Europe, and the double worldwide. Labrida has developed, clinically documented and CE marked a novel,patented (pending) maintenance device for non-surgical management of peri-implant disease. It is a revision brush(“BioClean”), with bioresorbable bristles made of mono-filament chitosan fibres (Patented by Medovent, DE). It offers safer,more effective, less painful and faster treatment of peri-implant disease, where currently the clinical community is in searchfor adequate solutions. The instrument addresses a market in the range of Euro 1-2 billion annual turnover.The device is in small scale production and sold commercially in Scandinavia (TRL 7), with most promising market response.To meet the market opportunity, we will develop up-scaled production processes of advanced chitosan fibres, which iscritical to increase overall production requirements. In addition, we have started development with clinical pilot testing of thenext generation product, comprising chitosan bristles combined with antibiotics, with interesting clinical results. This mayopen a broader application field for deployment of these combinations of materials technologies, both within odontology andwider in medicine.The overall planned project (Phase 2) comprises both industrial development of scaled up production technologies for thechitosan fibres of the currently marketed product , as well as development of the next generation product, combiningadvanced chitosan technologies with bioactive material, e.g. in nanospheres. In phase 1, we intend to refine thedevelopment plan of these product(s) for phase 2, including assessing more in detail the business case, and