RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'CHP gas turbine fuelled directly by a biomass gasifier'.

assistant: **Objectives**

The project is focused on the development of technically and commercially viable small (5 to 250 kWe) combined heat and power (CHP) plants involving a gas turbine fired directly by a pressurised biomass-fuelled gasifier followed by a cyclone combustor.  Direct-fired systems avoid the complexity and cost of sophisticated heat exchangers and offer a strong opportunity for commercial exploitation.  The project takes state-of-the-art combustor technology and advances it with the aid of computational fluid dynamics (CFD) modelling so that the gas stream entering the turbine contains less than 1 ppm alkali and 10 ppm particulates of a maximum size of 5 microns.  Turbine inlet and exhaust temperatures will be 850 and 600 C respectively; gasifier/combustor pressure 3 bar(a) with gas leakage <2%.  NOX is targeted at <90 vpm (15% oxygen).The gas turbine and its control and instrumentation systems have been commissioned and are ready to be integrated into a facility at Risø when the gasifier/combustor has achieved atmospheric operation.  The facility is planned to operate for 200 hours, providing data on performance, deposition, erosion and corrosion, together with validation of flow and control models.  The overall project is aimed at providing the essential data required to design a pre-production prototype of 250 kWe, within a capital cost for production units of 1000 ECU/kWe and a generated electricity cost of 0.06 ECU/kWh. This will be with a cycle efficiency of 23%(e) and 75% fuel utilisation in a CHP system.  The prototype design will form the basis for a follow-on project, which will incorporate fuel feed, high performance pressurised gasification and combustion, with a low cost gas turbine based on turbocharger technology.The project has a major potential to create new op
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DNA Damage Response (DDR) signaling in tumor formation and therapeutic resistance of gliomas' (DDR).

assistant: **Innovation**

The gliomas are a large group of brain tumors and Glioblastoma Multiforme (GBM) is the most common and lethal primary central nervous system (CNS) tumor in adults. Despite the recent advances in treatment modalities, GBM patients generally respond poorly to all therapeutic approaches and prognosis remain dismal. Standard therapy for GBMs includes resection of the tumor mass, followed by concurrent radiotherapy and chemotherapy, using the alkylating agent temozolomide (TMZ). Nonetheless, GBM patients remain refractory to treatment. Understanding the genetic events that lead to glioma formation and the mechanisms of resistance to therapy will be instrumental for the development of new treatment modalities for gliomas.Maintenance of genomic integrity is essential for embryonic development and adult tissue homeostasis. Defects in the DNA Damage Response (DDR) machinery, a network of protein complexes capable of detecting DNA lesions and signaling to downstream effector pathways (cell cycle checkpoints, DNA repair, apoptosis, etc.), are linked to numerous pathological states including brain cancers. The focus of this proposal is the identification of DDR genes involved in tumor formation and therapy resistance of gliomas. We will also investigate how the tumor microenvironment contributes to resistance to standard treatment modalities. We reason that these studies will help to define new therapeutic targets for treatment of brain tumors.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dual Co/Photoredox Catalysis for the Synthesis of Fluorine-Containing Skipped Dienes Featuring a Quaternary Carbon Stereocenter' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Fluorine-containing functional groups have become of crucial importance for medicinal and agrochemical applications. The incorporation of these moieties into molecular structures allows for significant opportunities to take advantage of bioisosterism as well as to fine-tune the chemical or pharmacological properties of a desired molecule. The objective of the FUSE project is to pioneer a novel approach for the preparation of fluorinated and chiral skipped dienes bearing a quaternary carbon stereocenter. Developing methodologies for these elusive compounds allows for a wide range of synthetic post-transformations and they thus serve as valuable building blocks in synthetic chemistry and pharmaceutical development programs. The project will expand the chemical space of hydrofluoroolefins (HFOs) and utilize these fourth-generation refrigerants as readily available and inexpensive starting materials. To achieve the challenging targets, a mild, visible-light photoredox based dual catalytic approach is utilized using earth-abundant (cobalt) first-row transitional metal catalysis. As such, the replacement of the typically hazardous metal reagents utilized in the state of the art and minimizing chemical waste is forecasted. The proposed programme will be carried out in close cooperation with an industrial partner in order to provide a new flow strategy for constructing these skipped fluorodiene scaffolds. This ambitious and innovative project will contribute to propagate the sustainability and reinforce the application potential of HFOs for academic and industrial applications. The project merges multidisciplinary aspects with intersectorial knowledge transfer, enabling the transition to more sustainable development in the fine chemical and pharmaceutical sector.


**Keywords:*
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'FUTUre RAil freight transport: cost-effective, safe, quiet and green!' (FUTURA), addressing dissemination and exploitation.

assistant: **Impact**

The FUTURA action will improve the quality and safety of life of over 55 millions of EU citizens, who live or work near train tracks. The main objective of the action is to provide last development steps for market launch of Divided Rail Freight Brake Disc (DRFB disc). DRFB disc is a revolutionary solution, influencing 3 key elements in the rail freight transport: 1) safety and security, 2) health and environment and 3) cost-effectiveness with strong horizontal and vertical ""spill-over"" effects and crucial social, economic and technical impacts.Today there are two competitive solutions: K-block and non-divided brake disc (the current state-of-the-art). Although non-divided brake disc is a superior solution (as it ensures higher safety, lower noise levels and less vibrations), it is used in practice in less than 10%, because it is too expensive. That is the problem that FUTURA action is solving. Our ambitious solution, DRFB disc, was developed by 4 high impact companies in the field of development, production and testing components for freight rail vehicles.The specific objectives of FUTURA action are: 10-15 dB lower noise, 11% shorter braking distance, 14% less vibrations, 21% lower mass, 7% less accidents, 12% less damage of freight, 50% longer life cycle of  wheels, 13% lower LCC of the disc. For an operator with 1,000 6-axle wagons, the savings within a life-cycle would amount to 5,838,000 € in comparison with K-block and 9,840,000 € in comparison with non-divided brake disc. DRFB disc will contribute considerably toward increasing the transported freight volumes via rail, which is environmentally friendlier than alternative modes (by road and air).Total available market size for our innovation is around 12 billion € per year. Our key target markets are EU, USA, Ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Auscultation non-destructive des sous-faces de dalles en beton arme'.

assistant: **Innovation**

Pathology of slabs is sometimes induced by cavity situated under the concrete part. The object of these research consists in creating a prototype of a non-destructive auscultation system that could be able to detect quickly and easily such voids . The impulsion technique so-called impedance mecanique", will be used. The research is divided in 4 distinctives parts: 1) description of the parameters that occur during the data acquisition (for example: accessibility on civil works) and definition of the characteristics of the prototype. Writing of the signal treatment algorithms. 2) creation of the system according to the parameters described in part 1. Writing of a dab acquisition program 3) experimentation in laboratory and on site. Re-writing of the programs to get them easier to use 4) Diffusion of the technique in Europe and writing of recommendation procedures "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Water and Drug Mobility at Silica Surfaces probed with DOSY NMR' (MOSUDO).

assistant: **Concept**

Europe’s pharmaceutical industry is faced with the multitude of lead compounds that are discarded during their development phase. One of the hurdles of most promising drugs is that they have difficulties reaching their site of action in the human body. This insufficient bioavailability results from the complex, poorly understood interplay between drug molecules, water and the surfaces of drug delivery materials and cell membranes. To tackle this challenge, a paradigm shift that recognizes water as headline act is proposed. The physical properties of water drastically change when approaching solid surfaces or cell membranes. Nobel Prize winner Albert Szent-Györgyi even described life itself as “water dancing on the tune of solids”. This research proposal aims to gain understanding of water and drug molecule mobility near silica surfaces. Silica materials in recent years popped up as most promising materials for drug delivery. Unravelling the complex interplay between drug, water and silica surfaces will equip pharmaceutical scientists with a generic toolbox to enhance the bioavailability of newly developed drug candidates. MOSUDO research focuses on probing the mobility of water, amino acids with varying hydrophilicity and a peptide drug in contact with silica. Diffusion-Ordered Nuclear Magnetic Resonance spectroscopy (DOSY NMR) is living spectacular developments and revolutionary sensitivity improvement. This project will take advantage of this development of DOSY NMR to investigate the complex molecule-water-surface interplay with new eyes. Fellowship applicant Dr. Randy Mellaerts can rely on a strong interdisciplinary background in surface chemistry and pharmacy. Acquiring in-depth technical expertise in DOSY NMR and its direct application in pharmaceutical industry w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Synthesis of Fluorinated Pyrrolidines' (FLUPYR) targeting Seventh Framework.

assistant: **Abstract**

Fluorinated nitrogen-containing heterocycles are key targets for the pharma- and agrochemical industry. Considering the poor accessibility of these compounds, we propose to explore new synthetic methodologies to access fluoropyrrolidines.  In the light of the abundant literature on electrophile-induced cyclisations, a very attractive route to access fluoro nitrogen-containing heterocycles is the electrophilic fluorocyclisation of alkenes bearing a pending nucleophilic amino group. However, this route is currently not possible because unactivated alkenes do not react with existing [easy to handle] electrophilic fluorinating N-F reagents. In this proposal, we propose two solutions to this problem based on the use of a silyl group to temporarily activate the alkene toward electrophilic fluorination. The first approach features a key electrophilic fluorocyclisation of various allylsilanes bearing a pending nucleophilic tosylated amino group.  This reaction generates silylated fluoropyrrolidines which upon oxidative cleavage release the desired fluorinated pyrrolidines. This route presents the advantage to allow for modulation of the stereochemistry of the targets as a function of the E/Z geometry of the allylsilanes.  The second solution features a syn selective iodoamination of  allylic fluorides also bearing pending nucleophilic N-tosyl groups.  The chemistry we propose to develop will be challenged with the synthesis of fluorinated biologically relevant targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Bentonite mechanical evolution' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The overall objective of the project is to develop and test the tools necessary for the assessment of the hydro-mechanical evolution of an installed bentonite barrier and its resulting performance. This will be achieved by cooperation between design and engineering, science and performance assessment. The evolution from an installed engineered system to a fully functioning barrier will be assessed. One of the challenges is to take into account initial heterogeneities introduced in the system by conception with a combination of block and pellets or due to the size of the bentonite component (several 100 m3). It will require a more detailed understanding of material properties, of the fundamental processes that lead to homogenisation, of the role of scale effects and improved capabilities for numerical modelling. The goal is to verify the performance of current designs for buffers, backfills, seals and plugs. The overall driver for the project is the assessment cases that will be defined at the onset of the project (WP1). The quantitative models currently available are not fully able to represent all the complexities of the evolution of an installed bentonite. A substantial effort is needed to improve both the conceptual approaches and the numerical solutions in the current models (WP3). The updated/newly developed models need to be tested and verified using available data (WP5).  There are some areas where fundamental data and the understanding of materials are incomplete. An efficient experimental programme will support model development and testing (WP4). There is already a large database from experiments performed within EC projects and national programmes, both laboratory and Underground Research Laboratory (URL) experiments. Many of the tests have been performed wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'SENSORS FOR INTELLIGENT GAS MONITORING APPLICATIONS'.

assistant: **Objectives**

The aim of the project is to develop smart hybrid sensors for environmental applications, e.g., as a combination of thick or thin film sensors and ASICs in a single package. Such smart sensors have the advantage that a lot of interfering noise (for example, temperature and humidity fluctuations) is eliminated. Smart sensors convert the sensor resistance into an industrial standard current signal (4-20 mA), which makes them easily usable in industrial environments. However, little work has been done in the field of smart environmental gas sensors until now.In the SIGMA project, it is intended to design and develop the technologies for the main components of a smart gas sensor and then to assemble these components, thus producing functional demonstrators of single gas sensors and sensor array units. The main components of the smart sensor units are: - the sensor resistor;- the ASICs;- the package.Finally the testing and characterisation tasks will be shared among the consortium members, whereas IMEC will guarantee proper management of the project, based on the experience gained in other EU funded projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Unearthing ancient social structures with sediment DNA'.

assistant: **Objectives**

Humans and other living beings are constantly shedding DNA, and this DNA is preserved in archaeological sediments. In 2021, I developed the first methods for reliably capturing and analyzing human nuclear ancient DNA (aDNA) from sediments, leveraging this abundant genetic resource as a reliable tracer of biological identity. For ancient societies, such aDNA has the potential to function as forensic “breadcrumbs” that trace the spaces inhabited by ancient individuals. At the well-documented, multi-phase Early Bronze Age settlement of Vráble, I will undertake a cutting-edge research program to obtain human aDNA from over 100 individual house floors, spanning the entire occupational area and 500-year history of the settlement. The UNEARTH project will reveal inheritance patterns and social organization, and map individuals from the cemetery back onto the spaces where they left their genetic traces. By integrating genetic, bioarchaeological, and isotope analyses, UNEARTH seeks to uncover socioeconomic stratifications and their role in prehistoric neighborhood organization. The methods developed in UNEARTH for extracting and analyzing human aDNA from sediments will have wide-ranging impact on archaeogenetics, enabling new analyses on archaeological sites, cultures and time periods that lack associated human remains. Crucially, UNEARTH will develop a robust framework for using human aDNA from sediments in cases where bones cannot be ethically sampled. By establishing new methodology and best practices for sampling and analyzing sediment aDNA, this project will unlock rich genetic records that are ubiquitous at nearly every archaeological site in order to elucidate the lived experiences of prehistoric Europeans at unprecedented resolution.


**Keywords:** Bronze Age, Populatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Traditional Food Network to improve the transfer of knowledge for innovation'.

assistant: **Concept**

In the European Union, Small and Medium Enterprises (SMEs) of the food sector are increasingly under pressure due to developing open markets, increasing demand of standardized and price competitive food products by the consumers, rising importance of large retailers and challenges in obeying governmental regulations. This raises the risk of losing many traditional foods as well as traditional processing techniques which are applied by SMEs using regional raw materials and often have a role in the cultural identity of regions.In urban centers in Europe, groups of consumers are increasingly demanding traditional, local and/or organic food productions as food poisoning cases and the dispute on GMO undermined public confidence on industrial food producing systems. To reach these markets, SMEs of traditional foods must extend their skills in modern as well as competitive marketing and production techniques to comply with existing European regulations and to promote the aspects of their products related to nutrition and health.To support these traditional SMEs, a knowledge transfer network shall be established with the focus on different food product sectors: Grains, fishes, fruits, vegetables and mushrooms. These food sectors are traditional, healthy foodstuffs which are essential for a balanced nutrition. To support traditional SMEs in these food sectors, a European network will interlink researchers, knowledge transfer organizations and associations of SMEs on European, national and region levels. The network will act as a mediator of information about innovations in production and marketing of traditional food, will foster entrepreneurship in the sector of traditional food producers and researchers as well as will develop strategic research and innovation agendas for the