RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular Insights into human NHE6: From Dimerization to Disease Implications' in the context of a Horizon Europe call.

assistant: **Objectives**

The human Na+/H+ exchanger 6 (HsNHE6) is crucial for regulating pH in recycling endosomes in the central nervous system. Mutations in HsNHE6 are linked to Christianson syndrome (CS), a severe neurodevelopmental disorder. However, the molecular mechanisms underlying HsNHE6 ion transport and its dysfunction due to CS mutations remain elusive. My research aims to bridge this knowledge gap by combining cellular and liposomal functional assays and single-particle cryo-electron microscopic structural investigations of HsNHE6. I will explore how dimerization in the lipid environment influences its ion transport mechanism, how the dimer functions as a whole, and how CS-associated mutations affect both dimerization and ion transport. I will conduct functional assays on heterodimeric HsNHE6, composed of wild-type (WT) and transport-deficient protomers, complemented by structural investigations to uncover the structure-function relationship during ion transport. I will identify HsNHE6-bound lipids and analyze HsNHE6 structure in its native environment utilizing detergent-free extraction. Furthermore, I will perform functional assessment in various lipid environments to unravel how the lipid environment influences dimerization and ion transport. Additionally, I aim to investigate whether and how CS-associated mutations lead to a loss-of-function phenotype and can exert a dominant-negative effect on a WT protomer by integrating functional assays with structural analyses of CS-mutant HsNHE6. The project aims to unravel the molecular mechanisms governing ion transport of HsNHE6 within the lipid bilayer and will provide insights into the molecular basis of CS.  By integrating functional and structural data, it offers the potential to guide therapeutic targeting of HsNHE6 in the context
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Mobile Web Applications for Future Internet Services'.

assistant: **Innovation**

With approaches like AJAX, Web technology and browser-based applications have become an important tool for developing Internet service front ends for the desktop. In contrast, Internet services on mobile are currently dominated by closed application stores" each requiring service development in a different native programming language instead of using unified Web technology.The MobiWebApp project supports the use of Web technology for developing mobile Internet services, bringing the advantages of Web applications from the desktop to the mobile world. Web applications are easy to deploy, they allow simple incremental updates and they can be developed quickly and at low cost due to a sizable existing developer base. Last but not least, mobile Web applications have the potential to overcome the current fragmentation in the area of mobile Internet services.Using unified Web technology for mobile applications is of particular interest for SMEs who often lack the resources to re-implement a mobile application for each of the different application stores in the market.MobiWebApp includes support for European outreach, training, the development of test suites and standardization in the area of mobile Web applications. Outreach will focus on disseminating results of W3Cs mobile Web application standards work to European developers and technology providers. The training events included in the MobiWebApp project will enable the European software developer community (and in particular SMEs) to become familiar with standards relevant for mobile Web application development. The project will also support working groups and related work supporting the development of mobile Web application standards.The project is lead by the World Wide Web Consortium (W3C), an industry consortium of cu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Study of the enhancement of the electron-ion recombination rate at very low energies' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Electron-ion collisions are fundamental processes which play an important role whenever ionized matter occurs. Several merged-beams experiments reported an enhanced recombination rate beyond theoretical expectations based on the theory of radiative recombination. Experiments are proposed to clarify this situation. Three-body recombination, one additional contribution to the recombination rate, should be measured to separate this process. For low transverse beam temperatures corresponding to 10 meV this process becomes comparable to radiative recombination. Furtheron dielectronic recombination resonance near zero energy which also contribute to the recombination rate should be measured. This work will also stimulate theoretical investigations in exact calculations of resonance energies. The ion storage ring CRYRING with its cooler, providing an electron beam with lowest beam temperatures, will be the most suitable tool for this work.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A New Labour Law for Supply Chain Capitalism' (2021-2027) under Horizon Europe.

assistant: **Objectives**

Labour law gradually protects fewer of the worlds workers. Changes in work and capital structure, new technologies and evolving modes of supply and production (together: supply chain capitalism), lead to an incongruence between the distribution of market power and the premises and tools of labour law, creating barriers to workers organization and agency. This incongruence stems from the fact that labour law developed in industrial economies to respond to the power disparities between capital and labour, and is therefore tied to a dyadic employer-employee paradigm in which labour law seeks to empower workers vis--vis employers, the presumed owners of capital. Yet this is no longer the case in the era of supply chain capitalism, where the direct employer is often a supplier in a Global Value Chain (GVC), whose economic calculus is dependent on corporations in higher tiers of the chain. Given the crises of both labour law and GVC governance, this project offers a path to restructure labour law to fit new patterns of supply chain capitalism. The project includes three main components: 1) Theoretical: The project intervenes in existing literature and theory on GVC governance and on labour law to propose a new analytical framework for reconceptualizing the role of workers and of labour law in GVC governance. 2) Empirical: Current initiatives to improve workers rights in GVCs worldwide are based mostly on voluntary schemes, often perceived as private or rooted in soft-law. The project will closely study existing initiatives and holistically analyse the studies development and examine whether and how labour law can be restructured to support existing successful initiatives and produce new sustainable paths to strengthen worker power in GVCs. 3) Normative: Based on the two prece
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unravelling the Dark Universe from the Canary Islands Observatories' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Astrophysical and cosmological observations imply that only 5% of the energy of the Universe is made of conventional matter. Therest is composed by a new type of matter, the so-called dark matter, which has no (or extremely weak) interactions with the knownparticles, and a yet more puzzling repulsive form of energy accelerating the universe's expansion (dark energy). Advancing ourknowledge on the nature of this dark universe is the focus of a global multidisciplinary effort in astroparticle physics. Indeed, solving these puzzles have been identified as a priority for the future of particle physics and cosmology by several scientific agencies worldwide.  In this context, UNDARK’s main objective is to transform the Instituto de Astrofísica de Canarias (IAC) into a world-class institution in astroparticle physics. This will be accomplished by leveraging IAC's expertise in astronomy and astrophysics with the excellence and theoretical expertise provided by the world’s leading particle physics laboratory (CERN), and three renowned EU institutions in astroparticle physics. UNDARK's work plan includes an ambitious program of networking, scientific events, staff exchanges and scientific collaborations that will significantly enhance the IAC's research capacity and creativity, and will increase its reputation within the EU and global R&I systems. This will be complemented by an extensive outreach program developed in parallel which aims to boost the recognition of the IAC within the general public and public funding bodies. Finally, UNDARK also incorporates training activities focused on research management to increase the management capacity of the IAC and its involvement in HE funding programs.    In summary, UNDARK has been designed with the goal of achieving excellence at th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A molecular laboratory on a chip' (MOLCHIP) under Seventh Framework.

assistant: **Objectives**

The manipulation of atoms above a chip using magnetic fields produced by current carrying wires is a mature field of research. This field was inspired by the notion that miniaturization of magnetic field structures enables the creation of large field gradients, i.e., large forces and tight potentials for atoms. It also has been crucial that present-day microelectronics technology makes it possible to integrate multiple tools and devices onto a compact surface area. Such atom chips have been used to demonstrate rapid Bose-Einstein condensation and have found applications in matter-wave interferometry and in inertial and gravitational field sensing. Likewise, the engineering of miniaturized electric field structures holds great promise for the manipulation of polar molecules above a chip. The ability of a molecule to rotate and to vibrate allows for the coupling to photons over a wide range of frequencies. This might enable, for instance, to implement proposed schemes of quantum computation that use polar molecules as qubits. The use of miniaturized traps also brings quantum-degeneracy for samples of polar molecules closer. However, experimentally proven concepts to load and detect molecules on a chip are still in their infancy. In this project, we will develop and exploit experimental methods to load and detect polar molecules on a chip. Molecules are directly loaded from a supersonic beam into miniaturized electric field traps above the chip. For this, these traps originally move along with the molecular beam at a velocity of several hundred meters per second and are then brought to a complete standstill over a distance of only a few centimeters. After a certain holding time, e.g., after the experiments on the chip are over, the molecules are accelerated off the chip ag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New Directions in Sustainable Catalysis by Metal Complexes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The discovery of novel sustainable catalytic reactions is a major current goal. Based on recent discoveries in our group, we plan to develop unprecedented sustainable catalytic reactions with special emphasis on reactions catalyzed by complexes of earth-abundant metals. We have recently discovered an intriguing reaction, namely the oxidation of organic compounds using water, with no added oxidant, evolving H2. This simple, selective reaction, offers now a novel, conceptually new, environmentally benign approach in the field of oxidation of organic compounds, which we will explore. We recently discovered a new mode of activation of multiple bonds by metal-ligand cooperation, including activation of CO2 and nitrile triple bonds, in which reversible C-C bond formation with the ligand is involved. Based on that, activation of nitriles has resulted in unprecedented C-C bond formation involving addition of simple aliphatic nitriles to various α,β-unsaturated carbonyl compounds. This mode of multiple bond activation may open a new approach to catalysis, “template catalysis”, which we plan to explore. In addition, the highly desirable, catalytic activation of the kinetically very stable, potent greenhouse gas N2O for the (so far elusive), efficient oxygen transfer to organic compounds, will be pursued. The use of CO2 in organic synthesis is an important timely topic. Based on its activation by metal ligand cooperation, new catalytic reactions of CO2 will be pursued, including unprecedented  carbonylation of non-activated C-H bonds. Most reactions catalysed by metal complexes involve noble metals. Development of sustainable catalysis based on complexes of earth-abundant metals is of great interest. In all topics described above, catalysis by complexes of such metals will be emph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Environmental and fisheries influences on fish stock recruitment in the Baltic Sea (STORE).'.

assistant: **Concept**

Understanding the stock-recruitment relationship of fish stocks is crucial for generating biologically sound advice for the balanced, sustainable exploitation of fisheries resources. At present the ICES Advisory Committee on Fishery Management uses the concept of safe biological limits (SBL) as a criterion to define exploitation and stock levels. This concept is based mainly on the assumption that below a certain spawning stock size, recruitment is negatively affected as a result of low egg production. When a stock is considered to be inside SBL, recruitment variability is expected not to depend on parental stock size, but rather be related to environmental and ecological factors influencing the survival of the early life history stages. So far, however, stock-recruitment relationships and critical stock levels identifying recruitment-limiting stock sizes are poorly defined for cod and sprat in the Baltic. The sensitivity of SBL's and reference points to environmental conditions, species interactions and parental stock structures for these stocks are uncertain and need clarification. The objectives of the research project are to:1. Determine stock-recruitment relationships for Baltic cod and sprat in relation to key environmental factors influencing the production of viable spawn and the survival of early life history stages.2. Improve short-term predictions of stock development by integrating recruitment estimates based on the present status of the stock and its biotic and abiotic environment.3. Develop predictive recruitment models for medium- to long-term forecasts of stock development under different environmental and fishery scenarios.4. Estimate biological management reference points, critical stock limits and target spawning stock sizes based on stock-recruitment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Smart Control of Energy Distribution Grids over Heterogeneous Communication Networks' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Stability and cost-efficient operation of Power distribution grids are the main targets of novel information-rich demand, voltage, and generation control, while at the same time aiming to reduce costs for the grid infrastructure. However, adding intelligence to the power grid requires communication and computation infrastructure, with consequent requirements for additional investments. To be cost efficient, it is therefore essential to enable intelligent power grid operation leveraging existing communication infrastructures.Goal of SmartC2Net is to develop, implement, and validate robust solutions that enable smart grid operation on top of heterogeneous off-the-shelf communication infrastructures with varying properties. The resulting innovative middleware functions are: (1) adaptive network and grid monitoring, (2) strategies to control communication network configurations and QoS settings, and (3) extended information models and adaptive information management procedures. These middleware functions create awareness of the communication network properties and their impact on information quality, which is subsequently exploited by innovative flexible power control algorithms of SmartC2Net.The effectiveness of project results will be validated in representative use-cases of the active operation of Distributed Energy Resources connected to medium and low voltage distribution networks. These use-cases are investigated in three complementary lab prototypes.The SmartC2Net results will clearly show that intelligent distribution grid operation can be realized in a robust manner over existing communication infrastructures even despite the presence of accidental faults and malicious attacks.A consortium of seven partners (two large companies, one SME, two research centres and tw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advanced Lubrication Modelling' (ALM) targeting Seventh Framework.

assistant: **Abstract**

This project focuses on the development and implementation of sophisticated mathematical models and methods that may be used to facilitate the fundamental understanding about mechanisms connected to the lubrication process of various applications such as, bearings, gears, cam-mechanisms etc. The long term goal is to deliver computational tools enabling prediction that in turn lead to improving the energy efficiency, reduced friction and wear and that mitigate the environmental impact caused by applications such as those previously mentioned. The contribution from surface topography and lubricant formulation on tribological performance are of special interest. An important task is to preserve as much generality of the models and the methods as possible, to cover a broad spectrum of applications. In this way the versatility will increase and the possibilities of applying the models and methods in other fields of research become more likely. This is realized by the application of rigorous mathematical techniques - to the equations that governs the lubrication process - that enable efficient treatment of the surface topography, the rheology of the involved fluid, the material characteristics, etc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dose sparing and increased immunogenicity of a pandemic influenza vaccine by CoVaccine HT' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The risk of a new influenza pandemic is emphasized by a WHO report documenting several hundreds of recent cases of human infection with a new virus strain and approximately 50% mortality. Control or prevention of a pandemic by emergency vaccination depends on availability of products with high efficacy and broad protection. The combination of an effective adjuvant and cell culture technology for antigen production meets the requirements of a pandemic influenza vaccine.The consortium of this FluVac project, among them proven and renowned experts in human vaccine development and influenza research, plans to deliver a prototype vaccine with proof-of-concept within 48 months. Optimal doses of inactivated, cell culture-derived whole influenza virus (H5N1) and CoVaccine HT as adjuvant will be tested in pre-clinical and clinical studies. In comparison to the widely used production system in eggs, production in cell culture offers the advantages of immediate and reliable availability of antigen of constant quality and with reduced risk of contamination. The use of whole virus in a vaccine instead of subunits, is considered to induce broader protective immunity.The novel adjuvant CoVaccine HT has been shown to elicit high humoral and cellular responses against different types of antigens, including inactivated influenza virus, and in different animal species (mice, rats, rabbits, pigs, horses, primates, etc.). It is considered to be a promising candidate for a pandemic influenza vaccine. A phase 1 trial, human challenge study and extensive immunological evaluation of the vaccine prototype will provide the information required for further development and registration.