RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Study of the interaction of the bioactive compounds by SPR imaging system' in the context of a Sixth Framework call.

assistant: **Objectives**

The main aim of the project is the further development of the applicant's skills and expertise in the application of the surface plasmon resonance imaging technique (SPR) for the investigation of interactions of proteins and other bioactive compounds.The project consists of two particular targets:i) the introduction of the SPR imaging technique to the host laboratory (University in Bialystok, Poland) in order to enhance host research potential in the area of interactions between cholesterol, phospholipids and cellular membrane proteins,ii) development of a sensor for different cathepsins. Cholesterol is the major component of cell membranes. It also plays a crucial role in arteriosclerosis development.The construction of a sensor with cholesterol immobilized on the sensor surface has potential for the investigation of cholesterol- protein interactions. Cholesterol mono-succilic acid will be immobilized to the thiol first layer on the gold chip. The immobilization will be performed with EDC and NHS application. Cathepsins are enzymes - lysosomal cysteine proteases, which play an important role in protein degradation, antigen presentation, bone resorption and hormone processing. These enzymes have also been implicated in tumour invasion and methastasis. Developing a sensor for cathepsins is considered ideal for the application of the SPR imaging system.In order to develop a sensor for different cathepsins, the strong interaction of cathepsins with cystatin will be used. Cystatin C seems to be the most suitable for this purpose. In order to immobilize cystaine C, different thiols will be investigated as the first layer on gold. The active group of immobilized thiol is the carboxy group or the amine group. These groups react with protein and create covalent bonds. The linea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of verified safe and sustainable PFAS-free coatings for food packaging and upholstery textile applications' (ZeroF).

assistant: **Concept**

ZeroF develops safe-and-sustainable-by-design (SSbD) coating alternatives to replace PFAS compounds in food packaging and upholstery textiles value chains. The developed coatings will have limited water absorption, high oil/grease resistance for packaging and high water and oil repellency for textiles. We propose the development of coatings from reasonably-priced precursors with estimated costs of ca. 0.2-0.4 €/m2 in the final product, which meets the remains under the targeted 20% increase compared to current alternatives. To reach the environmental impact target of >25% improvement, we  use renewable feedstock, non-toxic compounds and improve higher process efficiencies. PFASes are replaced by two chemistries, cellulose fatty acid esters for packaging and silane-based organic-inorganic hybrids for textiles. The project includes three work streams: food packaging, upholstery textiles and SSbD analysis. Both food packaging and textile workflows follow a similar path (chemical development, formulation, coating, and validation). The SSbD analysis actively analyses the data regarding  environmental impacts (Life Cycle Assessment, Life Cycle Cost, and Environmental Footprint) and toxicology (e.g., hazard and law, Green Toxicology principles). Computational methods are employed to model the toxicology and performance of developed chemistries in-silico, to reduce in-vitro testing and to generate tools for certification and standardization process. Certification and regulatory roadmap are developed to identify future regulatory needs and knowledge gaps. SSbD models are developed within the EC-suggested framework  to be easily adapted to other sectors beyond the project scope. A mix of research and industrial partners able to cover both packaging and textile coating value chain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CONCERTED INNOVATIVE APPROACHES, STRATEGIES,  SOLUTIONS AND SERVICES IMPROVING MOBILITY AND EUROPEAN TOURISM' (CONCERTOUR).

assistant: **Concept**

Tourism sector is a key driver of economic growth and employment and has a fundamental role in matching the Lisbon Strategy objectives: making the EU more competitive and dynamic economy.The recent communication ""A renewed European Union Tourism Policy:Towards a stronger partnership for European Tourism"" introduces the strategy to be pursued for better exploit growth and employment potentials of the tourism sector in a sustainable way.It also refers how the stakeholders can be involved in the EC actions.CONCERTOUR is an Horizontal Activity(Support Action)aiming at creating synergies between transport research and tourism services in Europe,improving competitiveness,encouraging co-modality,focusing on the subject regardless of the involved DG Programme.The overall objective is to propose new concepts guiding tourists through ""the stages of whole travel itinerary"" and to support EU policies in improving tourism competitiveness,considering emerging needs and tourism demand by acting on main aspects affecting tourism market (e.g.intermodality,information,ticketing).In CONCERTOUR tourism market and transport supply are considered as integrated environment,starting from the assumption that the local community is key to successful tourism destination as they are guardians of the local resources and provide the service for paying guests. The project will identify policy driven solutions to remove barriers,creating the conditions for value added transport services provision(e.g.institutions/instruments facilitating co-ordination between governmental departments in the planning phase,tourism travel plans,pricing policies and technical standardisation).The project focuses on transport as lever/opportunity and not as barrier to sustainable development and competitiveness,taking
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'International Network for Terrestrial Research and Monitoring in the Arctic' (INTERACT).

assistant: **Concept**

INTERACT aims for a geographically comprehensive and excellent  state-of-the-art terrestrial research infrastructure throughout the Arctic and adjoining forest and alpine regions to identify environmental change, to facilitate understanding and prediction of future change and to inform decision makers about societally-relevant impacts. INTERACT is the fundamental building block and one-stop-shop for EU and international projects, programmes and organisations requiring access to northern lands, data and services, and includes a rapid response capability to potential hazards. INTERACT is pan-Arctic, multidisciplinary and crosses EU call domains by linking to forest, coastal, marine and atmospheric communities. INTERACT uniquely unites 77 research stations in a Station Managers’ Forum ensuring inter-comparability of information and excellent science support. A Data Forum improves availability of data by bringing data providers together with data users. Physical (7780 days)  pan-Arctic Trans-national Access is offered by 43 stations and  virtual access is offered by 29. An innovative TA User Community will stimulate new collaborations and improved information flow while new state-of-the-art educational resources will encourage young scientists. Joint research activities will ensure close cooperation between the Arctic Council’s biodiversity monitoring programme and station activities; develop new technology in a WP led by Industry to enlarge the research stations’ environmental observing footprints; and produce guidance for local communities to adapt to change.INTERACT’s incalculable legacy and societal impact includes aiding people to adapt to local and global environmental changes, recruiting the next generation of environmental scientists, offering access and opportuniti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Regulation of gene expression of the imprinted H19-Igf2 cluster by higher order chromosomal organisation' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Higher order chromosomal organisation is an important determinant of gene regulation. Cis-regulatory elements, such as enhancers, Locus Control Regions and insulators that are spread over the DNA can be brought into close proximity. Three new applications have recently been developed to study this organisation: Chromatin Conformation Capture (3C), RNA-TRAP and the UAS-Gal4 method. Imprinted genes are expressed solely from either the maternally or paternally inherited alleles and many are clustered in the ge nome. These genes are marked epigenetically by DNA methylation and histon modifications. The imprinted H19-Igf2 cluster has been studied extensively. The paternally expressed gene insulin-like growth-factor 2 (Igf2) is separated by approximately 100 kb fro m the maternally expressed non-coding gene H19 on mouse distal chromosome 7. Recently it was shown that distally located regions in this cluster have paternal-specific interactions. Here, I propose to study the higher order organisation of the imprinted H19 -Igf2 locus, using a combination of the three new techniques.In the first place I am interested in regulatory elements that are in brought in proximity of the H19 DMR, and particularly of interest are differences in secondary structure between the paterna l and maternal inherited alleles. The contribution of single elements can be studies with various mice mutants established in the lab of W. Reik. Secondly I will study interactions of various enhancers downstream of Igf2 and the paternal copy of the gene in various tissues. This study will also reveal the placental specific enhancer sequences. In addition to determining DNA sequences involved in the higher order chromatin organisation of the H19-Igf2 locus, I would like to study proteins that are involved. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Quantum photonic integrated circuits at 1550 nm' (QPIC1550) targeting Horizon Europe.

assistant: **Abstract**

The goal of this project is to create a universal QPIC platform at 1550nm by integrating InP, Quantum Dots and InGaAs detectors on SiN PICs together for the first time. This new platform has the potential to revolutionise quantum photonics by enabling the creation of on-demand single photons and entangled photon pairs, with efficient single photon detection. Critical to this platform is its compatibility with existing optical fibre networks which makes this a cost-effective solution for quantum communication, computing, and quantum metrology applications. We demonstrate the flexibility of our QPIC platform in three different use cases: Quantum Key Distribution, Remote Quantum Computing and Quantum Clock Synchronisation experiments


**Keywords:** InGaAs, InP, Quantum Dots, SiN, QKD, Telecom wavelength, clock synchronisation, remote quantum computing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tandem reactions in a zirconocene template' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research Objectives To use carbenoid insertion into carbon-zirconium bonds to develop new organic synthetic methods. Content Zirconacyclo-pentanes and -pentenes are useful intermediates formed by carbometallation of unactivated alkenes or alkynes. Whitby has recently reported that they insert lithium chloroallylide followed by electrophiles providing reaction sequences in which 3 - 5 C-C bonds are formed. I intend to extend the range of carbenoids to give a variety of novel zirconacyclohexanes. Further elaboration of the zirconacyclohexanes using methods already reported for zircoancyclopentanes will provide efficient routes to a wide range of novel organic products. Training Content. In Dr. Whitby's group I will complement my experience of catalytic late transition metal chemistry with stoichiometric chemistry of early transition metals, including the isolation and characterisation of air sensitive organometallics. This will complete my formation in organometallic chemistry in order to join a French university in the following years. I will also extend my knowledge of the english language. Links with Industry Most of Dr. Whitby's group working on related projects are funded by U.K. industry (Glaxo, Pfizer, Zeneca, Lilly).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Reactive Synthesis in Action'.

assistant: **Objectives**

Bugs in software systems pose a huge and growing cost on society, not only in economic terms but also in direct risk to human lives. Reactive synthesis is a new technology to automatically generate correct-by-construction software. Unlike testing and formal verification, which require advance investment in an implementation, reactive synthesis generates a correct implementation directly from its formal specification.Despite its potential to reduce software development costs and at the same time increase the confidence one may have in the correctness of software, to date, no application of reactive synthesis has been examined outside academic labs. The SYNTACT PoC will put reactive synthesis technologies to test in industrial beta-sites and will thus generate and disseminate knowhow on the use of reactive synthesis in practice, identify and address product and process obstacles, build a community of parties that are interested in the promotion and transfer of reactive synthesis technologies from academia to industry, and lay a foundation to guide future research, standardization, collaboration, and industry investment in reactive synthesis technologies.We expect the SYNTACT PoC to advance the state-of-the-practice in reactive synthesis and thus start paving the way for its adoption in industry. Its expected outcomes include several industrial systems that were developed using synthesis, case-study reports describing the beta-sites projects, training materials, new set of real benchmark specifications, estimations of the potential return on investment in deploying reactive synthesis, and draft standardization documents. As more and more aspects of modern life depend on the correctness of software, the SYNTACT PoC will directly introduce the reactive synthesis correct-by-c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The MarginGuide: a medical device to improve the results of cancer surgery' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

SurGuide is a medical device company which aims to improve the results of oral cancer surgery. In the operating room, the surgeon has to rely on his hands and eyes to distinguish tumour from healthy tissue. This is very difficult. In only 15% of the cases, the tumour is removed with an adequate margin. When after surgery, during histopathological assessment, an inadequate margin is detected, the patient will receive adjuvant treatment (i.e. radiotherapy, additional surgery). This often causes lasting additional morbidity, with a negative effect on the quality of life. A fast and reliable methodology is needed to assess tumour removal with adequate margin, during surgery. The MarginGuide is being developed to meet this clinical need. It is a novel tool based on Raman spectroscopy; an optical technology. The MarginGuide consists of a Raman spectroscopic work station, a user-interface, and a fiber-optic probe employing disposable fiber-optic needles. It will be used to rapidly inspect the resection surfaces of the tissue that has been removed by the surgeon and will pinpoint locations where additional tissue should be removed to obtain an adequate margin. A proof-of-concept instrument is currently being tested. SurGuide expects to raise the success rate of oral cancer surgery from the current 15% to over 50%. No other device is able to measure the surgical margin in oral cancer surgery, which gives SurGuide a unique market position and the possibility to gain a dominant market share. Although, this is an ideal starting point, some market barriers still exist. In this project, SurGuide carries out a feasibility assessment covering a business feasibility study and partly a technological feasibility study. The objective of the feasibility assessment is to refine the business
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biology of Sponge Natural Products' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The research proposal concerns the biological aspects of a -so far largely - chemical field of study, i.e. natural products from sponges and their application for biomedical and industrial purposes. A cooperation of taxonomists, bioorganic chemists, ecologists and cell biologistis formed to address the biological aspects of the occurrence, cecllular origin and ecological function of selected natural products from sponge Research will be focussed on partly known and partly predicted occurrence of secondary metabolites of a monophyletic group of marine sponges. Aspects studied include: - biological activity of various extracts and structure of secondary metabolites found in purified fractions, - in situ production of these secondary metabolites under various environmental conditions (depth, temperature, latitude, predation intensity and substrate competition) - secondary metabolites and molecule types as chemotaxonomic markers - within-sponge spatial distribution of sponge cells and microsymbionts under various environmental conditions - identification of microsymbionts - isolation and culture of sponge cells. Together these aspects will allow conclusions concerning (I) the biological significance of sponge secondary metabolites for the producing organism and the environment interacting with it, (2) the causes o observed variation in occurrence and quantities of sponge secondary metabolites, and (3) the recognition of microsymbiont vs. sponge cell involvement in the production of promising secondary metabolites. These conclusions will have a direct bearing on policy decisions concerning industrial production of sponge natural products which are too difficult or costly to synthesize. A major deliverable of the proposed research will be the formulation of a standard protoco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Molecular Mechanisms of Fungal Pathogen Host Interactions'.

assistant: **Objectives**

ImResFun shall provide state-of-the-art training in infectious disease research and medical immunology targeting the most common human fungal pathogens, the opportunistic Candida species. The key objectives of ImResFun are: (i) to understand how immune cells and infected organs respond to invasion by Candida spp, (ii) to decipher host-defense mechanisms mediating pathogen elimination, and (iii) to identify genetic networks driving the dynamics of host-pathogen interplay. ImResFun will exploit cutting-edge technologies to unravel the basic mechanisms of fungal pathogenesis and host immunity, and to improve diagnosis and identify novel biomarkers of infection. Importantly, ImResFun will translate research into clinical practice and identify potential targets for antifungal drug discovery. ImResFun has seven WPs. In addition to coordination (WP7), research will cover molecular mechanisms of host-pathogen interactions using dual-system infection biology in vitro and in vivo (WP1), clinical patient setting and age-related infections (WP2), chemical biology and antifungal drug development (WP3), and bioinformatics and genome-wide data analysis (WP4). A compulsory and tailor-made practical course (WP5) and complementary skills (WP6) program will boost hypothesis-driven projects. Meaningful exposure to the private sector is ensured by extensive secondments of all ESRs/ERs. The resulting reciprocal technology transfer will be beneficial for both SMEs and ESR/ER hosts and sustain collaborations among partners. ImResFun will use personalized career development plans for each ESR/ER to train entrepreneurial scientists capable of translating frontier research into clinical practice, biotechnology and drug discovery. Taken together, ImResFun offers a best-practice example for interdi