RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Future Internet testbeds/experimentation between BRazil and Europe - EU' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

In the last two decades networks, and especially the Internet, have become part of the critical infrastructure of governments, businesses, homes and schools. The current Internet architecture, designed about 30 years ago, has suffered many extensions in recent years, to include new functionalities, which were unforeseen in the original design. Many network experts now consider it is necessary to undertake the study of alternative architectures for the Future Internet as a truly effective way to resolve many of the pressing problems that currently afflict the Internet.<br/>However, one serious obstacle to effective adoption of such innovations has been the inability to validate them convincingly. The reduction in real-world impact of any given network innovation is due to the enormous installed base of equipment and protocols, and the reluctance to experiment with production traffic, which have created an exceedingly high barrier to entry for new ideas. The result is that most new ideas from the networking research community go untried and untested, leading to the commonly held belief that the Internet infrastructure has ossified".<br/>Having recognized the problem, the network research community is developing alternative solutions for experimental FI research, using programmable testbed networks such as those of GENI in the USA, AKARI in Japan and FIRE in Europe. The main goal of the FIBRE project is the design, implementation and validation of a shared Future Internet research facility between Brazil and Europe, supporting the joint Future Internet experimentation of European and Brazilian researchers. In order to achieve this goal the project will carry out four main activities:\tThe development and operation of a new experimental facility in Brazil, including the se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Study and modification of T-cell receptor structure to enhance anti-tumor activity' (2007-2013).

assistant: **Innovation**

Adoptive cell transfer of tumor-reactive lymphocytes has been shown to mediate the regression of large solid tumors in cancer patients. To overcome the need to isolate and expand tumor-reactive lymphocytes that pre-exist in the patient, it is possible to engineer cells to express a tumor-specific T-cell receptor - TCR, thus reprogramming their specificity. This pioneering therapeutic approach has been demonstrated to cause cancer regression in terminal melanoma patients that were refractory to previous treatments. However, little is known about TCR affinity requirements for mounting an optimal immune response in this context. While high affinity TCR may confer to the host lymphocyte excellent cytotoxic ability, several studies have shown that a too-high affinity may actually be detrimental to T-cell function. We therefore hypothesize that T-cell receptor affinity can influence the cytotoxic activity of lymphocytes in TCR-transfer treatment and that it is possible to define an optimal range or threshold of TCR affinity for mounting an efficient anti-tumor response. To test this, we propose to use the ovalbumine specific OT1 TCR model and to construct a CDR3-modified TCR library that will be retrovirally transduced into a reporter cell line. By combining the efficacy of a high-throughput screening method and the direct selection of mutant TCR ex-vivo, we are planning to isolate several TCRs with different affinities. These molecules will be transduced and expressed in primary lymphocytes to assess their biological function in-vitro. Using the B16-OVA melanoma model, we will adoptively transfer lymphocyte populations expressing mutant TCRs with different affinities and compare their activity in order to study the influence of TCR affinity on anti-tumor cytotoxic response.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Intelligent Multi Agent Robotic Systems' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

The iMARS vision aims to revolutionize emergency services by harnessing AI, robotics, IoT, and cross-disciplinary expertise. This research program facilitates collaboration among three first responders, an industrial SME, and four research institutions, fostering the exchange of knowledge and personnel across sectors and borders. Its core impact lies in promoting a holistic problem-solving approach and practical innovation in emergency response through:1. Multidisciplinary Collaboration: Leveraging diverse fields to create solutions surpassing the limitations of individual disciplines.2. Knowledge Exchange and Mobility: Offering secondments to blend academic and industrial insights, ensuring real-world applicability of research.3. Professional Development: Providing training to develop a skilled workforce ready to deploy advanced technologies in emergencies.4. Creativity and Entrepreneurship: Cultivating an environment where innovation flourishes, potentially sparking new ventures focused on emergency services.5. Sector Interaction: Ensuring direct involvement of end-users, from first responders to industry experts, guarantees that developments are user-centric and actionable.6. Technological Advancements: iMARS addresses the full technology spectrum, from data acquisition to advanced communication, aiming for comprehensive enhancements in emergency operations.7. Humanitarian Focus: Prioritizing the use of robotics in search and rescue to improve outcomes for society reflects the project’s commitment to humanitarian values. iMARS stands to redefine emergency service provision, making it more robust and efficient. By aligning cutting-edge technology with strategic collaboration, iMARS sets the stage for global advancements in emergency management and could become a bench
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Scalable Charge-transfer Artificial Lattices for Enhanced Reproducibility' (SCALER).

assistant: **Concept**

Project SCALER (Scalable Charge-transfer Artificial Lattices for Enhanced Reproducibility) aims to advance and democratize quantum materials engineering. In an era where quantum technologies promise revolutionary advancements, the need for reliable, scalable methods to study and manipulate quantum materials is critical.Our research objective is to develop a reproducible platform for creating artificial superlattices in two-dimensional materials, making advanced quantum research more accessible to the broader scientific community. Current approaches like moiré superlattices and cold atom systems, while valuable, face limitations in scalability and real-world applicability.SCALER combines two main techniques to address these challenges:1. Refining high-resolution electron-beam lithography methods.2. Utilizing thermal probe lithography to create ""charge-transfer superlattices.""This two-year project, hosted at the Technical University of Denmark (DTU), will involve close collaboration with experts in nanofabrication, materials science, and quantum physics. We aim to achieve sub-20 nm resolution in patterning, demonstrate charge-transfer superlattices, and explore new quantum states in engineered 2D materials.The expected scientific impact includes advancing fundamental quantum research. By focusing on scalability and reproducibility, SCALER aims to provide tools that researchers across various institutions can reliably use and build upon, potentially accelerating progress in the field of quantum materials.For me as a researcher, this fellowship represents a crucial step towards becoming an independent research leader. It will enhance my expertise in advanced lithography techniques, project management, and interdisciplinary collaboration. The training provided by DTU, incl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Bio-inspired electrONIC NOSE interfacing olfactory electrical biosensors and carbon NANOtubes'.

assistant: **Innovation**

The goal of this project is to develop an innovative biosensor for the non-invasive, painless and real-time detection of volatile biomarkers in the exhaled breath of patients. Volatile biomarkers have been identified for several diseases including cancers, diabetes, cystic fibrosis and neurodegeneration. A miniaturized system for fast and simple breath-analysis would not only improve the early detection of these pathologies but also enable point-of-care monitoring of patients either in medical institutions or at home.Different electronic noses are in development (or even in use for diagnosing asthma), however their generalisation in reliable medical diagnosis devices is mainly hindered by their poor versatility. The main challenge is to quantitatively and simultaneously detect several volatile biomarkers with high specificity and selectivity. The ideal technology would be one which mimicked the natural olfactory systems that recognize odours by combinatorial analysis of receptor responses.Inspired by this biological example, this project aims at integrating natural olfactory receptors into two state-of-the-art technologies: Ion Channel-Coupled Receptors (ICCRs) and single-walled Carbon NanoTube-Field Effect Transistors (swCNT-FETs). ICCRs are original biosensors created by fusion of G Protein Coupled Receptors (GPCRs) with an ion channel. The recognition of a chemical compound by the GPCR is transduced into an electrical signal by the ion channel. Mammalian olfactory receptors are GPCRs, and the objective of this 5-year project is to engineer an original library of olfactory ICCRs for multiplex detection of volatile biomarkers. To detect the electrical signal with very high sensitivity and at the nanometric scale, ICCRs will be interfaced with swCNT-FET transistors by c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel selective mTORC1 inhibitors' (2014-2020).

assistant: **Innovation**

Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and the fourth leading cause of cancer-related deaths worldwide. The multikinase inhibitor sorafenib is the only approved drug to treat HCC and on average enhances survival by three months. Thus, the efficacy of current HCC treatment options is very limited. Studies in the context of our ERC-Synergy grant revealed that sorafenib resistance correlates with upregulation of mammalian target of rapamycin complex 1 (mTORC1) signaling. The central role of mTORC1 in conferring therapy resistance suggests that effective therapy against HCC may require combination of a primary inhibitor (e.g., sorafenib) and an mTORC1 inhibitor. The mTORC1 inhibitor rapamycin and its derivatives (rapalogs) are approved for a few advanced cancers, but not for HCC. Their clinical applicability is limited by their effectiveness and safety. Rapalogs fail to completely inhibit mTORC1 as they have little effect on inhibiting phosphorylation of 4E-BP, one of the two main targets of mTORC1. Moreover, rapamycin and rapalogs also inhibit mTORC2 when chronically administered, leading to undesirable effects such as hyperglycemia, hyperlipidemia, and insulin resistance. We have established a biophysical assay to identify selective mTORC1 inhibitors with a novel, rapalog-unrelated, mechanism of action. We predict these inhibitors to be more selective, more effective, and potentially safer than mTORC1 inhibitors currently used in the clinic. In this Proof of Concept project, we aim to study the pharmacological potential of selective and efficient mTORC1 inhibition alone or in combination therapy with sorafenib to treat HCC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Evolution and identification of the fungal genus Chaetosphaeria and related moulds' (EVOCHA) under Sixth Framework.

assistant: **Objectives**

The taxonomy of microscopic fungi is fundamental to the biological sciences, and a critical component of global management of biodiversity, agriculture, forestry, pharmaceutical discovery, food production, medicine, and molecular genetics. Robust species and genus concepts, combined with effective diagnostic protocols, are essential for understanding biological systems and vital for reproducible science. International projects such as Assembling the Fungal Tree of Life" and "BarCode of Life" demonstrate a need for training fungal taxonomists to document all organisms on Earth. An effective means of classifying asexually sporulating fungi, most of which belong to the largest fungal phylum, Ascomycota, is a great problem in fungal systematics. To develop a robust taxonomy reflecting evolutionary history, this project is designed as a polyphasic study, with emphasis on phylogenomic molecular data for a group of pigmented moulds.The research focuses on moulds with a particular mode of spore development, many of which are part of the life cycles of the sexually reproducing ascomycete genus Chaetosphaeria. These moulds are classified in 16 artificial 'form' genera that include about 250 known and perhaps many undiscovered species, cosmopolitan in distribution with a centre of evolution in the tropics. Chaetosphaeria has a long history of taxonomic problems, resulting from the simple, uniform morphological characters of its species. This fungal group is an example where evolutionary change is more evident in asexual rather than sexual morphology, which makes it of theoretical as well of as practical interest. Our main goal is a world monograph of Chaetosphaeria. To achieve this, we will employ a spectrum of standard and novel methods: microscopy, in vitro experiments, field an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Third international workshop virus-like particles as vaccines" (VLP-WORKSHOP)"' (VLP-WORKSHOP).

assistant: **Innovation**

In 1995 and 1998 the 1^st and 2^nd International workshops on Virus-like particles as vaccines were held at the Charity Medical School in Berlin. Encouraged by the success of these two previous workshops the organization of a third work- shop was decided and a scientific committee was founded. Whereas the first two workshops were mainly focussed on the presentation of the different virus-like particle carriers useful for vaccine development, the forthcoming workshop is died- cited to specific vaccine development against highly important viral pathogens as hepatitis B virus, human papilla virus, human immunodeficiency virus, hantaviruses, rotaviruses and others. A main task of the workshop is to convene leading experts working in basic research (studying molecular biology, pathogen city, epidemiology and immunology of virus infections) and experts developing vaccines (researchers, pharmaceutical companies, admittance authorities). In addition, the workshop should strengthen already existing collaborations in the EC (meetings of the participants of con- tracts QLK2-1999-01119 and QLRT-1999-31476) and allow establishing new collaborations not only between research groups but also with pharmaceutical companies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Savings Loyalty System Based on Micro-Contributions from Retailers' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

PENSUMO was founded as a result of the combination of our board's previous experience of 20 years in the field of retail loyalty plans and its social commitment to the sustainability of pension savings. On one hand, public and private retirement funds are under an increasing pressure due to factors such as the difficult economic situation or the ageing demographics. On the other hand, the retail industry is in need of more attractive, efficient and affordable consumer loyalty solutions to attract customers. PENSUMO aims to provide a solution to both problems, by offering a significantly improved and socially conscious consumer loyalty mechanism that will be beneficial for all retailers, the general consumer and society as a whole. PENSUMO provides any retailer with the possibility to adhere to our model and offer an intuitive savings scheme as an enhanced customer loyalty feature. By purchasing products in any of these stores, the consumer will automatically receive a fraction of the purchase amount back on a savings account, through one of our insurance partners. Each purchase will automatically add successive micro-contributions to his account. In terms of social responsibility, PENSUMO users will also be able to increase their funds by participating in civic campaigns, covering activities such as recycling, sports or road safety initiatives. PENSUMO provides stores with a unique selling point in a very competitive market. As a complimentary retirement fund for the general consumer, it covers the growing demand for additional financial stability, with an average extra contribution of €20.000 to the user's pension. For society, on top of an outstanding tool for the promotion of civic behaviour, it provides a complementary financial source of pensions. Consumer benefit,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A Correct-by-Construction Workbench for Design and Verification of Embedded Systems' (COCONUT) under Seventh Framework.

assistant: **Objectives**

Design and verification of modern embedded platforms are two highly related problems which are still mainly addressed by using unrelated methodologies. This effectively reduces development productivity and complicates achieving predictable system properties.<br/>The COCONUT project thus focuses on the definition of a formal framework based on a tight integration of design and verification through all refinement steps of an embedded platform design flow, from specifications to logic synthesis and software compilation. In particular, it is intended to propose a modelling and verification flow to enhance and speed-up embedded platform design and configuration with particular regard to application fields related to mixed continuous/discrete models, like for example networked multimedia and sensor network managing.<br/>In this context, the main activities of COCONUT will be related to the definition of innovative methodologies and tools to:<br/>- define and validate properties that represent the design specification; <br/>- automatically synthesize properties into code; <br/>- map models between hybrid and discrete domains; <br/>- provide correct-by-construction abstraction/refinement processes; <br/>- perform post-refinement verification. <br/>Such activities will be implemented in a set of tools working on more that one abstraction level whose correctness will be formally proved.