RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Exploring functional inter-individual variations in the intestinal microbiome for personalized nutrition' (InterBiome).

assistant: **Innovation**

The intestinal tract is inhabited by a large and diverse community of microorganisms, collectively referred to as the microbiota. When stably maintained, the microbiota provides important benefits to its host. However, disturbance of the microbiota-host relationship can perturb homeostasis and drive chronic intestinal inflammation, a cardinal feature of an array of diseases including Inflammatory Bowel Disease.     While many factors regulate microbiota composition and function, numerous studies have revealed a central role for diet in modulating this complex community and, consequently, its impacts on host health. My research group has investigated how microbiota is impacted by components of processed foods, particularly emulsifiers and purified fibres. We have reported that these substances have marked modulatory potential on the microbiota in a way that broadly impacts host physiology. However, the extent of such modulations is not uniform but rather subject to high levels of inter-individual and microbiota-dependent variations. These observations have led to the central hypothesis driving the InterBiome proposal, namely that the intestinal microbiota is a central nexus in driving inter-individual variations in the extent to which various dietary factors impact health.     We will investigate this hypothesis via a combination of integrated experimental approaches, including patient-based prospective studies, in vitro microbiota modelling and gnotobiotic approaches. Results of these studies will define mechanisms by which the intestinal microbiota drives inter-individual variation in responses to select food additives in a way that promotes or degrades intestinal health. The InterBiome project will open novel avenues of microbiota research, paving the way for microbio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel Scaffolds by Mild Photochemical Rearrangement of Reactive Enolate and Organolithium Anions' (PHOTOLITH) targeting Horizon 2020.

assistant: **Abstract**

We propose to develop new photochemical reactions of conjugated anions with lithium counterions (organolithiums and enolates) to construct functionalized, fused heterocyclic frameworks of use in medicinal chemistry development. N-Allyl/N-benzyllithiums tethered to aromatic and heteroaromatic carboxamides will be employed in dearomatizing cyclizations for the construction of partially saturated fused ring systems, generating extended lithium enolates. Irradiation with visible light at low temperature will induce a series of photochemical rearrangements, delivering – in an operationally simple way - structurally demanding unusual products containing various heterocycles and hetero-fused skeletons based on norcaradienes, cycloheptatrienes, and cyclic ketones. Trapping the reactive cyclopropane units of the products with dipolarophiles such alkynes and olefins will extend the method to dearomatized polycycles via a [3+2] cycloaddition strategy. The method will then be extended from enolates to coloured, conjugated organolithiums more generally, promoting an electron from the HOMO (the C–Li bond of metalated carboxamides) to a new higher energy SOMO. This excited state takes the form of an anion-diradical which may be expected to undergo further interesting inter- or intramolecular reactions to furnish biologically relevant structures.


**Keywords:** Modern LED, [3+2] Cycloaddition, Anion Diradicals, Norcaradiene, Organolithium, Rearrangement, Dearomatizing Cyclization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Probing local ROS distributions in Calcium signaling microdomains after myocardial infarction' (MICROS).

assistant: **Innovation**

An increasing number of people suffer cardiovascular diseases and experience myocardial infarction (MI). The subsequent heart remodeling is characterized by weaker contractility, hypertrophy and lethal arrhythmias. The poorly-understood underlying mechanism is related to calcium (Ca2+) mishandling in cardiomyocytes and oxidative stress. To date, most of the studies described global cellular processes and were unable to propose efficient therapies. This work will decipher the structural and functional local organization of reactive oxygen species (ROS) at Ca2+ signaling microdomains: at the vicinity of ryanodine receptors (RyR). Our knowledge is drastically hampered by the lack of local, quantitative and time-resolved ROS probes. We will thus combine the host laboratory competence in cardiac signaling and physiology, and the applicant expertise in ROS luminescent probes in order to quantify the RyR signaling domains remodeling through: (1) the measurement of local ROS production dynamics by NOX2 complexes, and (2) the imaging of the structural remodeling of the microdomains. This research will propose specific molecular targets to better diagnose and potentially reverse heart remodeling after infarction, contributing thus to solve a major public health issue in Europe. The experienced researcher (ER) will gain new technical and conceptual skills in physiology which will reinforce her multi-disciplinary profile and qualify her to lead, in a close future, her independent research activity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Debris flow management and risk assessment in the Alpine region.'.

assistant: **Concept**

The project aims to produce a few example evaluations of Debris Flow Risk in selected areas, forecasting the occurrence and behaviour of such flows, identifying areas prone to debris flow risk in some experimental basins, and defining an exemplified methodology for the evaluation of debris flos risk in prone areas that can be used by the concerned agencies.In order to reach the objectives some basic laboratory experiments are performed aiming to gain better  information on the mechnaical behaviour of mixtures of different grain sizes including segregation effects, and  to refine the rheological description of the transition between quasi static conditions, typical of geotechnical  analysis, and collision dominated conditions, typical of development flow behaviour, both in granular and muddy  debris flows.  Refined channel experiments are performed on free surface granular, muddy and intermediate debris-flows,  specially aimed for testing mathematical models, as well as simple experiments on possible triggering  mechanisms of debris flow.  Mathematical models representing the behaviour of debris flow are developed and implemented. 1-D and 2-D  models will be used. 2-D models may be both vertically integrated (2DH) and plane vertical flow (2DV). The  variety of models represent the effects of erosion and deposition, as well as the vertical segregation and  longitudinal differential convection mechanisms, responsible of the concentration of great boulders in the front  of the debris flood event. Models are verified and calibrated against laboratory tests and prototype data.  Field investigations are performed in order to identify debris source areas and to estimate the debris production  and accumulation rates. Debris flow events in the investigation areas are monitored an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Graphene Nano-Photonics' (GRANOP) targeting Seventh Framework.

assistant: **Abstract**

Graphene, a single-atom layer of carbon, has attracted enormous attention in diverse areas of applied and fundamental physics. Due to its unique crystal structure, the charge carriers have zero effective mass and can therefore travel for micrometers without scattering, even at room temperature. While graphene-based devices have an enormous potential for high-speed electronic devices, it has recently also been recognized as a photonic material for novel optoelectronic applications. Surprisingly, little attention has been devoted to graphene-based nanophotonic applications where optical fields are confined far below the diffraction limit. Due to its ultrasmall thickness and extremely high purity, it supports extremely strong wave localization at the nanoscale (also identified as surface plasmons) with relatively low losses. Moreover, graphene can be tuned from a semiconductor to a metal simply by applying a gate voltage, holding promise for in-situ tuneability of strong light-matter interactions at a length scale far below the wavelength. This makes graphene the ideal material to synergize nano-optics and electronics at the nanoscale.This research will demonstrate the application of graphene as a novel nano-photonic material that outperforms greatly existing photonic materials (cavities and metals). We will engineer ultra-strong and coherent light-matter interactions between single emitters and graphene, and implement several quantum electrodynamics (QED) applications.This research will address fundamentally new phenomena associated to the peculiar properties of graphene, while the development of this novel type of integrated nano-optoelectronic device will enable potential applications ranging from nanoscale (quantum) optical switches and quantum information processing,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Symbolic Analysis of Temporal and Functional Behavior of Networked Systems' (SYMBIOSYS).

assistant: **Concept**

The goal of SYMBIOSYS is to assure the reliability and interoperability of networked (software) systems, a crucial requirement in today’s networked information society. To this end, we devise a software and systems analysis methodology that – for the first time – considers the vital influence factors that determine the behavior of networked systems, especially including input and temporal uncertainty of network interactions. With SYMBIOSYS, we will be able to automaticallyand effciently explore and analyze the vast amount of distributed execution paths in networked systems in a highly structured manner inspired by Symbolic Execution (SE).The combination of the benefits of model checking (rigorous exploration) and of dynamic software testing (analyzing real systems’ code) represents a quantum leap in the field of network analysis. Orthogonal to and complementing formal model-based approaches, which target the design of reliable systems on an abstract (model-) level, we also address system- andimplementation-level aspects of (typically heterogeneous) implementations that interact via unpredictable networks. To achieve this, we introduce the fundamentally new approaches Symbolic Distributed Execution (SDE), Symbolic Temporal Execution (STE) and their symbiosis (SDTE). This is a breakthrough in the symbolic analysis of real systems and significantly widens the scope of SE to new analysis domains.Our novel approach raises the issue of complexity and path explosion. Yet, our experience from early work on SDE strongly suggests that the use of domain-specific knowledge and further general optimization strategies allow to significantly reduce this complexity and enable an efficient analysis. SYMBIOSYS also enables and fosters the design of new methods and tools to ensure reliabi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'CRISPR genome-editing of corals to understand the genetic response of corals to ocean warming' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The CORALCARE project studies the genetic response of corals to ocean warming. The world’s coral reefs are being severely impacted on a global scale by rising temperature that has led to increased coral bleaching and mortality. It is uncertain that these unique ecosystems will be able to adapt to this unprecedented pace of warming. Coral reefs are often referred as the ‘rainforest of the ocean’ and their potential loss puts an astounding EUR 9 trillion of biodiversity and ecosystem services at risk annually. The major goal for the management of coral reefs is to both predict the ability of natural coral populations to adapt to future climate change and to assist this evolution, in order to minimise their loss. However, assisted evolution requires a deep understanding of coral genetics, which is still in its infancy. This is why the overarching project aim is to understand genes and pathways that lead to thermal tolerance in corals. For the first time in the world, the cutting-edge genome-editing CRISPR/Cas9 and CRISPR/dCas9 techniques will be developed in corals, and allow us to disrupt gene function as well as turn genes on or off, to identify thermotolerance-related functions. The project aim will be tackled by: (1) scaling-up the CRISPR/Cas9 method for high-throughput gene editing during the short annual coral spawning, and establishing the CRISPR/dCas9 method for gene regulation in corals; (2) editing corals using the two CRISPR methods to test the function of candidate genes. The research is topical and highly innovative in using CRISPR genetic engineering for functional genomics, which will strengthen Europe’s quality and attractiveness in R&I. To undertake this research, the early-career researcher who has expertise in evolutionary biology will receive training i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Innovative Dermatology Healthcare based on Label-Free Spectral Optoacoustic Mesoscopy', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Multispectral Optoacoustic Tomography (MSOT) brings a revolution to bio-optical imaging. Being insensitive to photon scattering, MSOT dramatically improves upon conventional bio-optic barriers by enabling (1) three-dimensional high-resolution optical imaging deep inside tissues (several millimetres to centimetres), by (2) high-scalability, ranging from optical-resolution microscopy to acoustic-resolution optical mesoscopy and macroscopy and by (3) novel label-free anatomical, physiological and molecular contrast at the tissue and single-cell-level, based on spectrally-resolved optical absorption. MSOT, originally supported by an ERC Advanced Award (2008) (TUM: Prof. Ntziachristos), is already commercialized by iThera Medical for macroscopy with systems sold around the world for small animal imaging. In parallel, ERC MSOT funding developed a mesoscopic implementation, termed raster-scan optoacoustic mesoscopy (RSOM), which has demonstrated innovative imaging capacity at 1-5mm depths. Driven by leading dermatologists (TUM: Prof. Biedermann; SUR: Prof. Costanzo) and market leader SMEs in optoacoustic and ultrasound technology (iThera, Rayfos, Sonaxis), INNODERM will design and prototype a handheld, portable, scalable, label-free RSOM device for point-of care dermatology applications, based on recommendations developed under an ERC proof of concept grant (2013) on MSOT. INNODERM brings together key photonic & ultrasound technologies and will validate the technical and economic viability of RSOM in dermatology suites for fast diagnosis and skin disease monitoring. RSOM can go beyond the abilities of current optical or optoacoustic devices and offer a paradigm shift in dermatology imaging, substantiating successful business cases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Rural Riches. The bottom-up development of Post-Roman Northwestern Europe (450-640)' (450-640).

assistant: **Concept**

The question as to how Europe emerged from the collapse of the Roman state in the West has been the subject of academic debate for over a century. Most modern authors agree on the idea that the post-Roman economic development was the result of the initiatives and the demand of the elite. This paradigm of elite control of production and (long-distance) trade seems to be at odds with the vast amounts of objects, often precious and of exotic origin, that are found in the thousands of richly furnished cemeteries of even the smallest rural communities. This project will analyse the importance of the rural population as consumers with access to global trade networks to the post-Roman economic development in northwestern Europe. It is of great importance to analyse the early economic development of this region because it became ever more important in the economic development of Europe as a whole in the Middle Ages and the Modern Period. With this ambitious archaeological project we aim to contribute substantially to the age-old debate on the origins of the European economy and to a general debate on the role of the mass of the population in economic processes in the past. The project consists of five subprojects aimed at studying the ‘lay of the land’, the development of burial rite, the circulation of objects and the exchange mechanisms in place, the development of production and how it was embedded in social contexts and related to cosmology, and the presence and character of the elite. The main body of data will be the cemeteries and the vast amount of objects they contained. Sophisticated analyses of the objects’ deposition contexts and distribution patterns, using GIS and data from the ‘lay of the land’ project will be carried out to better understand these ‘Rural Riches’
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Geometric Phenomena in High-Dimensional ProbabilityDistributions' under Seventh Framework.

assistant: **Concept**

The proposed project lies at the cross-roads of Convex Geometry,Probability Theory and the local theory of Banach spaces. We willstudy large classes probability distributions of geometric origin onspaces of a very high dimension, tending to infinity. A particular,important case is the uniform measure on an arbitraryhigh-dimensional convex body. Even though the latter class ofprobability distributions is quite diverse, we observe that somenon-trivial principles persist. For instance, any uniform measure ona high-dimensional convex set necessarily has some approximatelygaussian marginals. The recent years have seen progress in theanalysis of such high-dimensional measures. The proposed projectintends to deepen and extend these first signs of understanding, tocontribute towards a comprehensive theory of convexity-relatedmeasures, and to develop new methods for the study ofhigh-dimensional distributions in general.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'IMPact SHIELD Design B'.

assistant: **Objectives**

This proposal is to design and manufacture an innovative shield to protect critical components of an aircraft against high velocity shrapnel from an engine burst.  The concept proposed here exploits the weight advantages of high performance fibres, in a design that uses a net like fibre membrane for energy absorption.   Considerations for their integration in an aircraft are made.The proposal has come from a close collaboration between the Imperial College Consultants and Swerea SICOMP.  It is therefore the result of the combined skills in manufacturing structural composites for the defence and aeronautical industry as well as specific ballistic design skills.  Both institutes have the necessary skills, experience and equipment to design and manufacture a successful shield.  As both these institutes are non profit research establishments actively working to advance composite technology, the materials and techniques have been chosen based on the type of treat and the aircraft integration constraints and there is no constrain to use any one particular material supplier.  Publishing and dissemination of the results is also not a problem if so desired.""