RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Eco-friendly and customer-driven Sail plan optimisation service' (EcoSail) under Horizon 2020.

assistant: **Objectives**

The overall vision is to bring our patented EcoSail technology to full market maturation, to pilot the system and to arrive at its commercialisation as a new energy efficiency and cost-effective solution for the global maritime transport market. Our innovative route planning service will be a disruptive new market entry, reducing fuel consumption by at least 7%.  EcoSail is rooted in the clear market-pull caused by the industry need to increase its cost efficiency and decrease environmental impacts. It is the result of several EU-funded R&D projects (SpaceNav, Navtronic & Sectronic) leading to a verified and demonstrated prototype (at TRL7) and confirming the commercial and economic viability. In these projects, the SMEs (OSM, GMS, ONL) developed a roadmap for technical improvements and a strategic business plan on entering the global maritime transport market. The EcoSail project approach is to execute these plans; technically advance EcoSail to TRL8 (WP1) and qualify the service in real-life operations to reach TRL9 (WP3). To support commercial viability, we will conduct a range of market maturation activities in WP4-5 and secure a dedicated EcoSail 'Training Academy' for future maritime masters, users and commercial staff (WP2).  We bring together a strong consortium, the three lead SMEs with deep industry knowledge have teamed up with the world-class RTO, CHA, specialising in EO data and maritime training simulations, and a large offshore industrial target user (LAM), to successfully market launch and scale the ground-breaking EcoSail service platform.  EcoSail will create a measurable consortium impact - as accumulated revenues of €87.1m for the 5-year post-project (2020-24), with accumulated gross profit of €44m and employment growth of 95 FTEs, and 80 FTEs in our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sensitive nanoparticle assay for the detection of HIV' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

We will develop a new platform and assay for the detection of HIV p24 antigen in serum or blood. The advantages of a p24 test are that it can detect HIV in an early stage of the infection, before antibodies develop, and that it is quantitative. The DETECTHIV project aims at developing an extremely simple viral load test with only one reactant (grafted colloids). In a first phase, a magnetic nanoparticles assay will be developed for use in a microtiter plate with as goal a detection limit of 1 ng/ml. In a second phase, the use of nanoparticles on a microfluidic chip will permit to detect p24 to levels as low as 0.1 picog/ml, one to two orders of magnitude more sensitive than classical Enzyme Linked Immuno-Sorbent Assay (ELISA) p24 tests. Validation of our platform will be both done with recombinant p24 samples and patient samples.The principle of our test consists in optically detecting the formation of a colloidal gel of magnetic nanoparticles ('agglutination test'). The gel forms in a magnetic field under the presence of antigens that are capable of linking irreversibly two colloidal particles. Therefore the latter are grafted with antibodies that are specific to the p24 antigen. An agglutination test requires only one step with only one reactant and the detection is achieved through simple optical absorbance measurements, owing to the strong optical scattering modification when passing from nanometric colloids to the gelled state.In the microfluidic chip test, a sample solution of serum or blood is transported through a suspension of magnetic nanoparticles that are magnetically suspended within a microfluidic channel. When brought into a magnetic field, the particles will be able to approach each other, form chains and will be irreversibly linked if the p24 antigen is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nano-assisted digitalizing of cancer phenotyping for immunotherapy', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Every day cancer takes about 30000 lives worldwide, despite multiple treatments developed in the last 50 years. True revolution in the therapy is demonstrated by the immunooncology relying on multiple routes to activate the immune system, using e.g. Chimeric Antigen Receptors, checkpoints inhibitors. Although demonstrating success in the treatment of e.g. lymphoma, the percentage of patients responding to the immunotherapy is less than 30%. Even more, the activation of immune system does not happen at no cost, leading to severe auto-immune reactions, sometimes with lethal consequences. Therefore, the main question of clinicians is: how to efficiently predict the response/no-response of the patient to the immunotherapy? At present, there is no predictive technological platform combining both, highly sensitive analysis of the cancer immunity and the planning of the strategy for potential therapy. I consider cancer as a smart self-adapting machine that plays its own set of rules: it generates and quenches the biochemical signals; initiates the iterative loops and builds up feedback controls to create an immune suppressive environment. My idea is to digitalize these mechanisms. ‘ImmunoChip’ will develop a device combining microfluidics with the specific nanosensory network to study elements of the cancer-immunity cycle to bring a new dimension in the field of preclinical immunotherapeutic cancer phenotyping. The information about the immunosuppressive activity of the cancer microenvironment, immune checkpoints, T cells, efficiency of the immunotherapy, will be collected into respective data patterns. The developed ‘ImmunoChip’ platform will help to answer the questions: can the patient be treated with the immunotherapy? How does the tumor protect itself? Which immunotherapy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Control Over Noisy Communication Media'.

assistant: **Objectives**

Two of the fundamental theories within the discipline of electrical engineering are those of control and communication (along with its mathematical foundation, information theory [IT]). These theories have been studied extensively by mathematicians and engineers throughout the 20th century, and have gone separate ways.The primary objective of control theory is to stabilize and control the behaviour of a given dynamical system in a desired fashion by changing the system input according to its measured output (feedback). In this theory, adapting according to the feedback with minimal possible delay is of grave importance.The theories of communication and information deal with conveying reliably data over noisy media. IT seeks to determine the maximal reliable-communication rates possible, disregarding and often undermining delay and computational complexity. Communication theory attempts to approach the rates promised by IT using practical tools.In the past, control theory was mainly used in well-crafted closed engineering systems (e.g., car and aerospace industries). In the current technological era of ubiquitous wireless connectivity, the demand for control over noisy media is ever growing, enabling numerous new possibilities. Nonetheless, current theory and technology offer one of the following solutions: utilizing a communication scheme that improves reliability at the price of introducing a large delay and then trying to control the resulting system, or adapting solutions from classical control theory to control over unreliable media, known now as cyber-physical control.Indeed, due to the historic disjunction of these theories, no unified theory exists that determines the fundamental trade-off between communication reliability and rate, and delay and controllability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Gene Regulation at the Nuclear Periphery' to be submitted under Seventh Framework.

assistant: **Abstract**

The spatial organisation of the genome in the nucleus has a role in the regulation of gene expression. In vertebrates, chromosomal regions with low gene-density, and that are less transcribed, are located close to the nuclear periphery. Correlations have also been made between the transcriptional state of some genes and their location near the nuclear periphery. For example, the proneural Mash1 gene relocates away from the nuclear periphery when it is activated during neural differentiation of mouse embryonic stem (ES) cells. Recently, the host laboratory demonstrated that the nuclear periphery plays a direct role in gene repression by experimentally relocating genomic loci to the nuclear envelope. A crucial issue is whether this nuclear reorganisation is important for correct differentiation and development. To do this I will impair the relocation of Mash1 in ES cells by tethering it to the nuclear envelope with the lacO/lacI-lap2b system set up in the host laboratory. The consequences of this anchoring on Mash1 transcription and neural cell differentiation will be assessed. I also propose to investigate the mechanism of Mash1 relocation. First I will determine whether the nuclear position of Mash1 influences its chromatin state, by establishing the histone modifications of the locus, when tethered or not. Then I will address whether nuclear reorganisation is an active or passive process. In live cells, I will track the position of the lacO tagged Mash1 visualized with lacI fused to GFP, during neural differentiation. Finally, I will determine the endogenous pathways that retain specific loci at the nuclear periphery. I will perform two high-throughput screens on a human cell line established in the lab where a peripheral locus is visualized by laco/lacI-GFP. An siRNA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Strengthening of the environmental chemistry research'.

assistant: **Innovation**

This project is a novel and innovative effort to combine several methods and scientific disciplines such as electrochemistry, analytics and environmental technology, in order to develop an integrated, environmentally friendly and cost and time efficient remediation technique for selected contaminants in soil and water matrices. When implemented successfully, the proposed project has potential to overcome several limitations of the non-integrated techniques and methods currently in use, and the developed new technique can be a crucial key on the way of solving a global contamination problem. The Laboratory of Applied Environmental Chemistry (LAEC) at the University of Kuopio (UKu) will act as a host in the proposed project. LAEC is focused on the chemical treatment and analysis of soils and waters, and it has a global leading research position in the field of complexation chemistry in aquatic solutions. In order to be able to reach the scientific goal of creating a novel and innovative solution to a global problem, the weaker aspects of the knowledge base of LAEC need to be strengthened. This will be implemented by recruiting experienced researchers having wide knowledge of disciplines like: microbially enhanced electrokinetic phenomenon, microbial activities under the applied electric field and pH environment, technique enhancement methods, such as ultrasound and application of the most suitable electron donors and mediators, complexation chemistry and electrically assisted ion exchange. The project aims at strengthening the core competence of the LAEC. Moreover, it aims at networking and establishment of long-term research collaboration with high quality European and other international research partners. Networking and cooperation between the key players in the define
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Estimation of the term premium in Euro Area government bonds' in the context of a Horizon 2020 call.

assistant: **Objectives**

The European monetary authorities, as well as most central banks, are currently pursuing the objective of reducing the Quantitative Easing and normalize interest rates. A clear understanding of the forces underlying the movements in interest rates has thus become a timely and very relevant issue. In particular, a challenging task for policymakers is the estimation in real time of the unobservable term premium, which provides a measure of the investors’ perceived risk of holding government bonds. The purpose of the EUTERPE (EUropean TERm Premium Estimation) project is to implement an innovative system producing timely and reliable estimates of the term premium and its components for government bonds of the Euro Area (EA). The project aims to fill an important gap in the existing literature by proposing an integrated procedure which relies on a novel multi-country term structure model with interrelation between yield curves, macro variables, volatility, and global factors. EUTERPE intends to equip the European policymakers with a new analytical tool for their monetary policy decisions and has potentially various applications in the financial industry, thereby representing a way to use knowledge in Europe effectively for business and policy purposes. The specific training activity in research and transferable skills, the outstanding profile of the Supervisor, the excellent research environment offered by the host institution, and the interaction with a first-class network of European policymakers and research institutions are all factors which will contribute to increase my professional maturity and will allow me to restart a career in research at an advanced level. In particular, the publication of the results in highly reputable scientific journals and the other dissemin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'COMAL:COhesin Mutations in Acute Leukemia: from modeling and mechanisms to novel therapeutics' (COMAL) targeting Horizon 2020.

assistant: **Abstract**

Transcriptional dyregulation is a common driver in cancer and acute myeloid leukemia (AML) is an exemplar of this process. AML has a dismal survival rate of <30% with novel targeted therapies urgently required. My research focuses on improving our understanding of the biology of AML and using this knowledge to develop targeted therapies to improve outcomes. Recently loss-of-function mutations in members of the cohesin complex have been described in up to 15% of patients with AML. The cohesin complex mediates sister chromatid cohesion, an important process for DNA repair and proper chromosomal segregation. It has also recently been demonstrated to be important for transcriptional regulation, due to its coordination of communication between promoters and enhancer and insulator elements. Evidence suggests that transcriptional alterations underlie the mechanisms of transformation by cohesin mutations in AML. However, other evidence and my preliminary data also suggest cohesin mutant cells to have specific vulnerabilities related to their roles in proper chromosome segregation and DNA repair that can be specifically targeted.Objectives:1) Generation of mouse models of cohesin-mutated AML. To model AML in vivo and as a resources for Obj 2-42) Characterisation of transcriptional defects in cohesin-mutated AML using state-of-the-art genomic techniques (RNA-Seq, ChIP-Seq and Capture Hi-C)3) Define mechanisms of cohesin-mediated transcriptional regulation in normal hematopoiesis and its alteration in leukaemia using SILAC based proteomics and ChIP-Seq co-binding4) Therapeutic targeting of the cohesin complex in cohesin-mutant AML using compounds identified in a large screen and suggested by Obj 1-3 and tested in cell lines, patient samples and in vivo models.This proposal will in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Intermediate Compressor Case Duct Aerodynamics' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

To reduce fuel-burn and CO2 emissions from aero gas turbines innovative, very-high bypass ratio and smaller ultra-high pressure ratio core engine technologies are required as this will increase their propulsive and thermal efficiency. However, this makes the design of the intermediate compressor ducts connecting the various compressor spools much more challenging as the change in radius becomes much greater. The ability to design shorter, more aggressive ducts is advantageous from a performance and weight saving perspective but flow separation must be avoided if efficiency is not to be compromised or the downstream compressor performance not adversely affected. This programme of work will establish and validate improved and more integrated duct technologies that will contribute to the development of the very-high bypass ratio turbo fan demonstrator (UltraFan™). A fully annular, low-speed test facility incorporating a representative compressor stage will be used to validate, at low TRL, an initial compressor inter duct design. A representative bleed port will also be added upstream of the compressor to allow compressor/bleed/duct interactions to be studied. This bleed port is required in the engine to extract ice and water but currently little is known about how it affects the compressor or duct aerodynamics. The results will be used to develop and experimentally validate future potential duct technologies for the UltraFan™ engine and other very high bypass ratio applications. This will include a second design solution optimised for a more effective bleed extraction and/or lower impact on system performance and stall margin. In parallel to the experimental work this project will also establish best practice for advanced, yet efficient, CFD methods (e.g. hybrid RANS/LES).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Optimisation advanced optical coatings technologies competitive manufacturing'.

assistant: **Innovation**

* Plasma state diagnostics.* Optical diagnostic for transmission (or reflectance) monitoring of workpiece in plasma CVD deposition reactor.* In-situ closed-loop process control on two industrial plasma CVD deposition reactors.* Enhanced product quality (performance and reliability)and production yield demonstrated from one existing industrial coating plasma CVD deposition process for hard coatings, and expected on two more reactors.* The closed loop control was demonstrated using existing plasma CVD deposition processes on industrial reactors.* Significant empirical data on the behaviour of the industrial plasma CVD deposition reactors.* Design and characterisation algorithms for optical coatings.Thin film optical coatings are currently exploited in a vast range of industrial products from plate glass used in motor vehicles, and architectural scale window glass to high technology imaging systems with applications in medicine, firefighting, communications and avionics. The current world widemarket for optical coatings is in excess of 800 MECU. The industrial trend is towards tailored application specific optical coatings. For example imaging systems impose stringent requirements in terms of minimised reflection and maximised optical transmission bands, which have been addressed using conventional discrete layer coatings. Similarly, architectural glass manufacturers wish to develop optical coatings with custom spectral responses to reduce building environmental management costs. While the demand for specific coating optical properties varies with application, the requirements of the coating mechanical properties are becoming more stringent. This increasing market demand for advanced performance coatings has shifted the industry emphasis from low cost manufacturing to high