RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Bible and the Law in Carolingian Europe: Scriptural Exegesis and Royal Legislation from Charlemagne to Charles the Bald (ca. AD 780-880)' (BIBLACE).

assistant: **Innovation**

In what ways did the Bible shape the formation of political communities in early medieval Europe? This project studies the impact of biblical models on royal legislation in the Carolingian period (ca. AD 780-880). It proposes a new approach to the study of the intersection between religion and politics in a formative period of European history, during which crucial institutional and conceptual resources for the development of political and religious community, statehood and law were created. Under the Carolingian rulers from Charlemagne onwards, we can observe a steady increase of biblical quotations in legal texts issued by the ruler or by assemblies of lay and clerical advisers (so-called royal ‘capitularies’ and conciliar decrees). Biblical prescriptions and prohibitions were either directly integrated into legal norms or used to justify the establishment or modification of norms. To understand this convergence between biblical law and royal legislation, the rich material of Carolingian biblical exegesis is of crucial importance, since it provides access to the concepts and interpretative traditions associated with specific biblical texts in the minds of contemporaries. Authors and readers of exegetical commentaries were often at the same time advisers to kings and important political decision makers, and also involved in the drafting of legislative texts. The project thus proposes a comparative study of legal and exegetical texts and of their dynamic relationship. It has a twofold objective: first, to analyse the concrete impact of biblical models upon Carolingian society, and the ways in which they were used to (re)define its legal and moral framework; second, to understand the ‘social life’ of Carolingian biblical commentaries, both as a spiritual and intellectual
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Ammonium Transport in Plants: Strategic Role in Nitrogen Efficiency'.

assistant: **Objectives**

Summary Most plants,especially under agricultural conditions use both ammonium and nitrate as the main nitrogen sources absorbed from the soil. The importance of soil NH4+ absorption is particularly relevant for plant growth under conditions of poor nitrification where NH4+ is the prevalent nitrogen source. Furthermore, in nitrogen fixing root nodules fixed nitrogen is transmiKed from the bacteria to the legume plant cells in the form of NH4+. Since they control whether the ion is taken up into the plant, NH4+ transport proteins play a strategic role in nitrogen efficiency. Despite this, the first genes encoding NH4+ transporters were only recently isolated, from the yeast Saccharomyces cerevisiae and the plant Arabidopsis thaliana, respectively. These transporters were found to constitute a new class of transport protein and to be highly conserved from bacteria to plants and animals. There is evidence that multiple NH4+ transporters exist in both S. cerevisiae and A. thaliana and recent data on expression of plant NH4+ transporters in root hairs is strongly indicative of their pivotal role in nitrogen nutrition. Interestingly, ammonium transporters also function as ammonium sensors at least in yeast. Nitrogen sensing is certainly of major importance for the development of root architecture. A manipulation of ammonium uptake and sensing should thus allow to increase nitrogen efficiency of crop plants at two levels: optimized uptake through more efficient transport at the plasma membrane and through improved root structure and surface. The aim of this proposal is to carry out an integrated molecular and physiological analysis of NH4+ transport proteins in a variety of organisms (i) in nitrogen-fixing bacteria involved in transfer of nitrogen to the plant Rhizobium and in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Advanced Signalling, Automation and Communication System (IP2 and IP5) – Prototyping the future by means of capacity increase, autonomy and flexible communication'.

assistant: **Objectives**

X2RAIL-3 represents the 3rd proposal of the Shift2Rail members in the IP2 “Advanced Traffic Management & Control Systems” domain and it aims to continue the research and development of key technologies within the following Technology Demonstrators (TDs):Adaptable Communications for all Railways (TD2.1 / WP3) – The objective is to demonstrate, via the integration of the different prototypes into dedicated demonstrators, that a new Communication System will be able to overcome the shortcomings in current ETCS and CBTC communications and deliver an adaptable communications system usable for train control applications in all market segments. Moving Block (TD 2.3 / WP4) – the scope is to move beyond the laboratory preparations undertaken in the framework of the X2Rail-1 project and to develop technical demonstrators for suitable railways applications. Zero On-Site Testing (TD 2.6 / WP5) – In the context of the simulation and testing framework integrating new functionalities such as moving block/satellite positioning, finalising the general architecture and will as well perform specific prototypes. Virtually Coupled Train Sets (TD 2.8 / WP6 & WP7) – The action aims to perform a comprehensive study focusing on the new concept of “Virtual coupling”, which foresees that trains will be able to run much closer to one another and to dynamically modify their own composition on the move. Cyber Security (TD 2.11 / WP8 & WP9) – In the context of Cyber Security, the main objectives are to define a “Cyber-Security” System to railway and to contribute to a secure development standard applicable to railway applications.ATO over ETCS pilot test for freight demonstrator (TD 5.6 / WP10) – In the context of freight autonomous train operation, the main objective is to perform field testing with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Index of Middle English Prose: Digital Cotton Catalogue Project', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The Index of Middle English Prose (IMEP) is the most important reference tool for Middle English non-verse texts. It seeks, for the first time, to locate and identify all surviving English prose texts composed between c. 1200 and 1500. In this project I will aim at developing and testing an innovative digital search tool that will greatly facilitate accessing all entries across the different IMEP catalogues and make it possible to search for texts regardless of the wide range of spelling variation. The prototype of the digital search tool will be based on a draft of an IMEP volume for one of the most famous medieval manuscript collections in Britain: the Cotton collection in the British Library. I will, additionally, edit an IMEP volume for print publication.   The proposed research action formulates three main objectives. These seek to improve the functionality of the IMEP website, to expand the site with the addition of the Cotton volume and to lay the foundation for expansion of the IMEP by writing guidelines for the digitisation of further volumes.    Since I am trained in manuscript studies and Middle English as well as in Digital Humanities and compilation of corpora of historical texts, I possess the necessary expertise to undertake the research action. The action includes research trips to the British Library in London as well as a secondment at the Cambridge Digital Humanities (CDH). The host is the University of Oslo where local expertise is available that is highly pertinent to the research action, including the editor-in-chief of the IMEP and an IMEP advisory board member with complementary expertise in both manuscript studies, Middle English, and natural language processing. The research action will both consolidate and expand my profile to qualify me for a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel human neurodegenerative disease specific 3D cell-models with applications in drug development and toxicity testing' (BTech) under Horizon 2020.

assistant: **Objectives**

Drug development for Parkinson’s disease, Alzheimer’s disease, and further neurodegenerative diseases is struggling due to high failure rate and high costs. BTech is a new 3D in vitro Brain-on-a-Chip technology that can offer medium-throughput screening of drugs during pre-clinical testing that more accurately reflects the effects of drugs on humans than conventional 2D cell cultures and mouse models. The technology is based on microfluidics where cells are cultured in three dimensional hydrogel environments mimicking the conditions in vivo.BTech provides solutions for pharmaceutical companies, specialised biotech companies and academic researchers to test novel drug compounds with applications in neurodegenerative disorders and for toxicity testing. The business model is based on two applications:• As a Service in it`s own the laboratory, BT cultivates human stem cell derived neurons and midbrain organoids and then evaluates the application of customers’ compounds on them.• As a Product, the company offers ready-made midbrain organoids. These organoids are 3D structures with specialized brain cells that are spatially and functionally organized to mimic the physiological state of the human brain. The organoids are sold and shipped to customers and used directly by them as a research material or a pre-clinical model.During Phase 1, the feasibility assessment will focus on following technical and business objectives during its 6 months, to develop a robust plan for Phase 2, which intend to reach the industrial stage of development and commercialize BTech on the market. It intend to scout and involve companies from the pharma industry, such as Sanofi, Evotec AG, Farcoderm or UCD to validate in Phase 2 the software, platform and processes, by performing 2 test with a total
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Reducing Non-Human Primates in Non-Clinical Safety Assessment: The European Initiative on Minipig and Micropig Models' (NHPig) under Horizon Europe.

assistant: **Objectives**

NHPig is an Innovative Health Initiative (IHI) project based on the public-private partnership of the European Union and Europe’s health industries. Its objective is to expand, share and implement biological knowledge of mini-/micropig models with the aim to reduce non-human primates (NHPs) in non-clinical safety studies. The transnational consortium includes experts in porcine medical models, veterinary pathology, computational animal science, non-clinical science, OMICs profiling, new approach methods (NAMs), as well as bioinformatics and artificial intelligence. NHPig will i) characterise humanised minipigs, micropigs and tailored disease models, including systematic biobanking, multi-OMICs profiling, and state-of-the-art imaging modalities; ii) develop, validate and implement biosensors, medical devices, and ‘intelligent’ animal housing for automated data collection and analysis in minipig safety studies; iii) fill significant knowledge gaps in the (patho)physiology of the porcine immune system; iv) validate known toxicity and efficacy biomarkers and discover novel biomarker candidates for non-clinical safety assessment; v) overcome the shortage of laboratory tools and reagents, such as validated antibodies; vi) gain experience in using mini-/micropigs for safety testing of biologicals and new therapeutic modalities; vii) Investigate in vitro to in vivo extrapolation of liver and kidney toxicity in pigs and NHP/humans to  provide a comparative link to human new approach methodologies (NAMs); and viii) provide a publicly available database and IT platform for compiling, integrating and analysing existing data in NHPs/humans with data in mini-/micropig models (existing data and data generated within the NHPig programme). The establishment of a regulatory advisory boar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Perfused Organs-on-a-Chip integrated with TEER measurement technique: A novel approach towards studying non-targeted drug induced organ toxicity' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

PORTable STaNDOuTs aims to develop a multiple Organs-on-a-Chip (MOOC) microfluidic device integrated with electrodes for carrying out Transepithelial electrical resistance (TEER) measurements. The key motivation for adopting such an approach is to develop a rapid, versatile and cost-effective prototype with ability for real-time monitoring to replace the conventional long and cost-ineffective preclinical procedures involved in the drug development process. On administration of an oral pharmaceutical drug, major organs that are involved in the absorption and metabolism of drug are intestine and liver. The drug is then distributed to different target organs such as brain, heart, lung, etc. Finally, the drug metabolites are eliminated from the human system with the help of kidney.  Additionally, it has also been found that certain drug metabolites produced by the liver cause non-target drug induced organ toxicity. TEER measurement is a rapid and non-invasive technique for the real-time detection of pathophysiology. TEER indicates the integrity of the cell membrane barrier of different organs that is necessary for maintaining homeostasis within the human body. In view of this, we intend to fabricate a physiologically-mimicking perfused intestine-liver-kidney microfluidic chip with provision for carrying out in-chip TEER measurements. The device will be designed to consist of three compartments for organs namely, intestine, liver and kidney, independently equipped with electrodes for measuring TEER values to detect the integrity of cell membrane barriers in each organ compartment. The developed device will be then subsequently validated for its ability to study drug-induced nephrotoxity. Furthermore, the device will also be made versatile to incorporate other organs of inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Nano Art Research Tool' (NANOART) targeting Seventh Framework.

assistant: **Abstract**

“Our ordinary language has no means for describing a particular shade of colour” (Ludwig Wittgenstein in Philosophical Remarks, Chicago: The University of Chicago Press, 1984). This interdisciplinary project, combining Conservation Science, Nanotechnology, Restoration and Art History, aims to confront this problem regarding the binders applied in paintings, sculptures and illuminated manuscripts, which have a particularly diverse colour palette, rich in material terms as well as in symbolic and aesthetic values.Currently, the characterization of artwork binders (egg yolk, glair, gums and oils) requires microsampling combined with powerful but expensive techniques performed by specialized personnel. Despite all the advantages that nanotechnology has brought to molecular diagnostics and the healthcare industry in the recent years, the field of artwork preservation and conservation has not yet greatly benefited from nanobiosensing tools. The NANOART project will develop a nanobiosensor for the successful detection and identification of the biomolecules present in the paints of ancient artworks. This will lead to the development of a new and inexpensive “nanokit” based on gold nanoparticles which will allow to identify at point-of-care the nature of binders used in different artworks with an enhanced sensitivity. The gold nanoparticles will be used as a reporting agent enabling a colorimetric identification of different biomarkers that may be present in nanosamples taken from artworks, providing a unique opportunity to immediately explore the origin of the binders at the naked eye.The NANOART kit will hopefully be made available to conservation scientists from around the world, facilitating the knowledge over historical productions and help worldwide museums, conservation a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanics with Molecules' (MEMO) under Horizon 2020.

assistant: **Objectives**

In this project, single molecule-machines will be constructed and tested on a surface and one at a time, controlling the rotation and the work delivered by a single molecule-motor directly at the atomic scale. The molecule motors and gears, designed and tested by MEMO, will be further adapted to applications requiring collective and synchronous motion. The MEMO partners will design molecular motors and gears able to perform collective and synchronous motion. They will test the rotation of such molecule-gears step-by-step according to their chemical composition, the structure of their teeth, their rotational axle, and the supporting surface. MEMO will design molecule-motors adapted to transmit single molecule motion from the atomic scale to the mesoscale (and beyond). In MEMO, low-temperature UHV experimental methods including scanning tunneling microscope and four independent scanning probe microscopes on the same surface will be used, as well as atomic force microscope in solution. MEMO will explore how a molecule-gear with ~1 nm diameter can mechanically match a nanofabricated solid-state nano-gear with ~30 nm diameter, produced using e-beam nanolithography and He beam microscope. MEMO will create the first miniaturization roadmap for mechanical machinery down to the atomic scale. This roadmap will be explored node by node along the MEMO project, fabricating, micro-fabricating, and nano-fabricating a planar mechanical calculator down to the atomic scale. The last node of the roadmap, using all the molecular machinery results obtained by the MEMO partners during the project, will lead to the design of a molecular Pascaline. To disseminate the single molecule-mechanics results to industry, MEMO will organize regular Academy-Industry days with high-tech SMEs. General pub
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Newtinst ew3' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The Isaac Newton Institute for Mathematical Sciences is an international research institute that covers the broad spectrum of mathematical sciences. During 2002 the Institute will hold a number of interdisciplinary programmes and it is intended that one EuroWorkshop will take place during each of the programmes New Contexts for Stable Homotopy Theory and Computation, Combinatorics and Probability. The objective is to ensure that the work of the Institute is disseminated more widely in the European Community, and that younger people from that community are given the opportunity to participate in these areas of mathematically related sciences. The EuroWorkshops will explore an important topic at the cutting edge of the mathematical sciences and a number of young people will be involved, meeting a range of distinguished scientists.