RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Biological reference materials for organic contaminants (BROC)'.

assistant: **Objectives**

It is proposed to study the feasibility of the certification of polybrominated diphenyl ethers in fish and sediment, organochlorine pesticides in fish and polyaromatic hydrocarbons in mussels. The availability of certified reference materials (CRMs) could lead to a better analytical performance and a better risk assessment of these compounds with regard to consumer protection. The project provides information on sampling and preparation of the planned CRMs, homogeneity, and stability studies of the test materials, and a mini-workshop to instruct participants on appropriate techniques. An interlaboratory study will be organized of which results should be the basis for a future successful certification of the CRMs. A final report with conclusions and recommendations will be made as well as a Technological Implementation Plan in which the strategy for production, certification and marketing of the candidate CRMs is described.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Implementation of a vessel monitoring system on artisanal fishing vessels operating within the Mediterranean sea'.

assistant: **Objectives**

ARTMEDSAT is an Accompanying Measure designed to explore the adaptation of satellite vessel monitoring systems (VMS) - currently limited to large professional and industrial vessels - to the arzisanal fleet in -the Mediterranean Sea. The project will bring together in a workshop: fishery experts on the artisanal fleet, environmentalists, experts in satellite navigation, communications and maritime electronics, of Greece, Italy, France and Spain, to determine the optimal method for adapting VMS techniques to the physical and technical limitations of artisanal fleet.In particular, a combination of artisanal fishery data, environmental parameters, satellite position monitoring and mathematical modeling will be considered. The final objective of this Accompanying Measure is to formalize an innovative approach to VMS for artisanal fleet that can serve as the basis for a Fifth Framework RTD project as well as to identify the ideal team of partners to execute that project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'International Research on Quality in Healthcare'.

assistant: **Objectives**

International Research Project on Financing Quality in Healthcare InterQuality gathers the interest for financing systems' effect on quality of healthcare of researchers from seven EU countries and US. The study, based on administrative and survey data, is designed for 36 months. It will take into account needs of four different patient groups (sectors), affected by: hospital, outpatient, pharmaceutical and integrated care. The scope of research will cover: utilization of resources and efficiency, quality of care, including: equity of access, patient satisfaction and safety of treatment. Resources allocated by each sector will be analyzed in relation to risk of their overuse, underuse or misuse. Critical appraisal of individual contracts will be based on the New Institutional Economics theory. Principal-Agent framework, the new standard approach to modelling relationships between payers and providers in healthcare, will be applied to the analysis of reimbursement schemes.  The first two work-packages will prepare theoretical background and collect statistical data in required format. Dedicated Data Warehouse will be launched and exploited by all project participants. Work-packages 3-6 will perform core analytical work by building and testing sector-specific models and delivering expected project results. The research will be conducted in Poland, Italy, Denmark, Germany, United Kingdom and United States. Each of the chosen countries has different health care financing system therefore the comparison of the results and outcomes, addressing different aspects of financial incentives' effect on quality of care, will advance the knowledge base on sustainability of the health systems. Further knowledge gained from the project will provide support for Member States to choose th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dependable Distributed Systems' (DeDiSys) under Sixth Framework.

assistant: **Objectives**

Distributed software systems are a dominant factor for sustainable economic growth of the European Union, serving as a basis for innovative applications. Especially SMEs will identify successful business cases by focusing on specialised know-how in the global market of software components, services and infrastructures. The key element for achieving scalable and maintainable distributed software systems is dependability, because otherwise the complexity of distribution would leave the system uncontrollable.Our proposal aims at a concept for optimizing dependability in distributed component-based software systems and comprises an architecture, rules for technology integration, open platform services, well-defined metrics and evaluation methods, and necessary prototype implementations. By promoting the idea of open systems, we do not aim at a new  middleware, but rather at the integration with existing component infrastructures and commercial off the shelf products. Furthermore, DeDiSys is not a method for testing and verification, but rather a highly innovative method to deal with failures of nodes and links.Technically, dependability is an aspect of every part of the system. Similar to other approaches we use replication as means to provide transparent fault-tolerance and persistence, but we are especially focused on the trade-off between availability and consistency by using a mixture of asynchronous and synchronous replication techniques.  This trade-off can be measured and configured to allow an application-specific optimum of availability. As there is currently only little research in this area, the results of DeDiSys would clearly go beyond the state of the art.Future exploitation of DeDiSys will include safety critical applications for air traffic control and publi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ANCA-associated vasculitis European randomised trials', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Introduction: The purpose of this proposal is to improve the treatment of a group of rare, multisystem diseases in order to save lives and improve the quality of life for survivors. This can only be achieved by performing randomised clinical trials (RCTs) on a multinational basis. Background: Anti-neutrophll cytoplasm autoantibody (ANCA)-associated systemic vasculitis (AASV) is a group of severe, multisystem, autoimmune diseases (e. g. Wegener's granulomatosis and microscopic polyangiitis), which cause marked incapacity and chronic morbidity due to irreversible organ damage, such as renal failure. The incidence of AASV is increasing, especially in the elderly, and exceeds 25/million/year. Care outside specialist centres is often fragmented and treatment suboptimal. The toxicity of current treatments contributes to incapacity through high cumulative exposure to steroid and cytotoxic drugs. This proposal will improve the efflcacy of treatment, reduce disease-induced damage and minimise drug toxicity. Methods: Four RCTs will test new therapeutic approaches, already piloted in single centres, and are targeted at patient subgroups, covering the entire spectrum of the diseases. They will aim at: ù improving disease control with intravenous immunoglobulin or sulfamethoxazole/ trimethoprim in addition to standard treatment ù lowering cyclophosphamide toxicity by replacing continuous oral treatment with pulsed intravenous administration ù reducing relapse rate by elimination of nasal carriage of Staphylococcus aureus ù reducing relapse rate by long-term, low dose azathioprine treatment in place of treatment withdrawal The RCTs will utilise innovative statistical techniques and trial methodology. Prognostic markers and surrogate end-points will be defined to optimise clinical dec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Automated electronic gravure printing process' under Fourth Framework.

assistant: **Concept**

The AUTOGRAVURE Project intends to standardize the process of electronic engraving of cylinders for the gravure printing process and the integration of digital technology in order to automate it. The RTD goals being: (a) to achieve work standards which will allow to reach a repetitive quality level given certain process prerequisites, and (b) To integrate digital technology in the electronic engraving process which will allow the automation of the process. In order to achieve these standards it is necessary to develop a methodology by building sets of correlation curves driving to the standarization of the electronic cylinder engraving process taking into account, all process variables such as base cylinder material (Electroplating operation process variables), engraving mode (reticle inclination and concentration, diamond type) ink characteristics, printing material (metallic, plastic, etc.), colours combination, etc. A relevant area will be the development of photography trapping SW in order to standardize the photography and graphics data handling. Also the avoidance of pre-production proofing processes Due to this approach the collaboration and integration of the different disciplines, technologies and/ or know how holders involved is a fundamental issue. A quantitative objective would be to be able to speed up the response time to a new customer requirement of 48 hours. Also the avoidance of existing proofing processes which are lengthy and costly.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Non-Stationary Non-Homogeneous Turbulence' (NoStaHo) targeting Horizon Europe.

assistant: **Abstract**

A wide range of radical technological breakthroughs are needed across all industries and engineering because of the dramatic current climatic, environmental and population growth constraints on energy, energy efficiency, polution and emissions. Turbulent flows are a key limiting factor in a vast range of these industries including the aeronautical, automotive, chemical, pharmaceutical and environmental engineering industries to name but a few. Step-change technological innovations in these industries therefore require rapid and reliable turbulent flow prediction methods which are currently unavailable. The stalemate in turbulence prediction methods reflects an 80-year stalemate in our fundamental understanding of turbulent flows. The past 5 years, however, have seen a number of advances which overturn cornerstone turbulence textbook material and create an unprecedented opportunity for a potentially decisive breakthrough in our fundamental and general understanding of turbulent flows which are typically non-stationary and/or non-homogeneous. These recent advances concern non-stationarity and non-homogeneity in fundamental ways and open new research opportunities with many new questions and hypotheses. This project will seize these new research opportunities with a combination of laboratory, computational and theoretical methods and approaches applied to a variety of turbulent flows. The expected outcome is a transformative, entirely new and extensive, fundamental understanding and theory of non-stationary and/or non-homogeneous turbulence, and a consequent road map for future disruptive turbulent flow prediction methods.


**Keywords:** turbulent flows, turbulence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Discovery of mevalonate and UBIAD1 inhibitors as novel drugs targeting melanoma skin cancer'.

assistant: **Innovation**

Melanoma is the most aggressive skin tumor, extremely difficult to treat and with high mortality rate. Overcoming reduced sensitivity and acquired resistance to targeted therapy is a major goal of current melanoma research. Therefore, there is an urgent need for development of novel drugs that can cure and prolong the survival of melanoma patients. Molecular targeted therapy by using a drug that reduces the growth and spread of cancer cells via inhibition of specific protein or pathway is a milestone of precise medicine and treatment.  Recent observations demonstrate that BRAF and MEK inhibitors induce increased reactive oxygen species (ROS) in melanoma and as a consequence tumor cells activate adaptive antioxidant mechanisms to keep their cellular redox state below a deadly threshold. Thus, it has been proposed that removal of antioxidant could be exploited for therapeutic benefits. In our ERC Consolidator grant RENDOX we have characterized the mevalonate metabolic pathway and discovered that this metabolic pathway as well as its enzyme, UBIAD1, have antioxidant properties and are critical caretakers of oxidative stress and ferroptosis in pathological conditions, such as melanoma progression. The MELASTOP project is grounded on the validation and repositioning of pre-existing inhibitors, such as statins and parabens derivatives (UBIAD1i) as novel therapeutic drugs to treat melanoma resistance, which represents an extraordinary opportunity to improve the current limitation. The current ERC PoC proposal aims at lead optimization, preclinical validation, IPR positioning, marker assessment and other commercial activities including go to market strategy and dialogue with potential collaborators of these mevalonate and UBIAD1 inhibitors. We envision that this PoC represents
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cooperation To promote Economic and technological Intelligence IN SMEs' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The little use of ETI by small companies in Europe is to be counteracted by participation and active measures in order to make them aware of the importance of managing strategic information at the pace of the present development of world economy. The AM proposal is aimed to identify awareness actions and methods at work on ETI for SMEs in the proposed regions. From this information, a benchmarking process will be performed to discover good practice in SMEs. The good practices will be disseminated through publication (guide, website) and organising regional workshops for SMEs, counting on experts in Economic and Technological Intelligence. Lastly, a pilot action involving a selected group of companies already experienced in ETI will be involved in a transnational seminar of exchange of experiences and preparation of joint projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Tools for the Investigation of Transactions in Underground Markets' (TITANIUM) under Horizon 2020.

assistant: **Objectives**

TITANIUM will develop novel methods and technical solutions for investigating and mitigating illegitimate activities (relating to either crime or terrorism) involving virtual currencies and/or underground market transactions. Specifically, the project will:* Establish a research and development environment that enables close and continuous collaboration between researchers, developers, legal experts, and law enforcement stakeholders in several European countries and regions* Analyse legal and ethical requirements for tools and services, elicit technical requirements from LEA stakeholders, and establish a development ecosystem that ensures compliance with these requirements and supports the generation of court-proof evidence* Implement tools for the automated aggregation of data from diverse sources, including the dark web, the surface web, and other sources and devices obtained through legal warrants, using multi-modal adaptive crawlers, stealth facilities, and smart filters* Provide services for the simulation of criminal activities and the generation of synthetic data* Investigate customizable heuristics, which can operate across different virtual currency transaction ledgers and identify clusters of addresses that are likely to belong to the same real-world entity* Apply novel techniques based on machine-learning and deep neural networks for revealing patterns, detecting anomalies, and identifying tumblers and mixers used for money laundering* Deploy forensics tools and services to partner LEAs and conduct Field Labs to assess the effectiveness, ethical and legal compliance, and overall impact of the results and to validate those results at technology readiness level (TRL) 6 or higher* Prepare curricula and carry out training and joint exercises that will facilitate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Understanding hepatic macrophage activation by microbes and microbial components in vivo' to be submitted under Horizon 2020.

assistant: **Abstract**

Despite playing essential roles in immunity against microbes, the cellular and molecular mechanisms underpinning macrophage (mac) responses to microbial insults remain incompletely understood. In the liver, Kupffer cells (KCs) the tissue-resident macs, reside in the bloodstream of the liver sinusoids and are thus ideally positioned to recognize and phagocytize microbes and microbe-derived components critically contributing to systemic immune surveillance. In addition, KCs are thought to play central roles in maintaining tolerance for example to gut microbiota and/or their products which reach the liver through the portal vein. Upon inflammation/infection, monocytes are also often recruited to liver which, in addition to KCs, participate in immune defence and tissue repair and can differentiate into recruited macs (rMacs). Due to similar expression profiles and functions it has not been possible to unambiguously discriminate between resident KCs and rMacs in the past hampering our understanding of the processes underlying hepatic mac activation by microbes and microbial components. By combining my expertise in host-microbe interactions with the expertise of the host lab in myeloid cell biology, here, I aim to dissect the mac responses to microbial insult in the liver. To achieve this, I will use KC-specific mouse models and human liver organoids combined with novel single cell technologies, with a focus on mac fate, activation profile and tissue context. My preliminary data demonstrate that systemic microbial insult leads to significant heterogeneity within the hepatic mac pool and hence I hypothesize that individual populations may become differentially activated in order to effectively clear microbes and microbial components from the liver. Understanding the processes