RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'THALAssaemia MOdular Stratification System for personalized therapy of beta-thalassemia', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

THALAMOSS is aimed at development of universal sets of markers and techniques for stratification of β-thalassaemia patients into treatment subgroups for (a) onset and frequency of blood transfusions, (b) choice of iron chelation, (c) induction of fetal hemoglobin, (d) prospective efficacy of gene-therapy. At present, no framework exists to guide therapeutic decisions and personalised treatment of β-thalassaemia.THALAMOSS Workpackages: WP1. Recruitment, patient characterization and development of erythroid precursor cells cultures; WP2. Omics analyses; WP3. Novel therapeutic approaches; WP4. Data analysis; WP5. Dissemination and exploitation; WP6. Regulatory and ethical issues; WP7. Management.The impact of THALAMOSS is the provision of novel biomarkers for distinct treatment subgroups in β-thalassaemia (500-1000 samples from four European medical centres), identified by combined genomics, proteomics, transcriptomics and tissue culture assays, and establishment of routine techniques for detection of these markers. Translation of these activities into the product portfolio and R&D methodology of participating SMEs will be a major issue. THALAMOSS tools and technologies will (a) facilitate identification of novel diagnostic tests, drugs and treatments specific to patient subgroups and (b) guide conventional and novel therapeutical approaches for β-thalassaemia, including personalised medical treatments.Key researchers of THALAMOSS are R.Gambari (Ferrara University, Italy), M. Kleanthous (The Cyprus Foundation for Muscular Dystrophy Research, Cyprus), S.Philipsen (Erasmus Universitair Medisch Centrum Rotterdam, The Netherlands), E.Katsantoni (Biomedical Research Foundation, Academy of Athens, Greece), S.Rivella (Cornell University, NY, USA - The Children's Hospital of Phila
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Advanced training and acquisition of knowledge with AMS-02' in the context of a Sixth Framework call.

assistant: **Objectives**

Florian Hauler is applying for an outgoing Marie Curie fellowship with the Massachusetts Institute of Technology (MIT) (contact person Nobel prize laureate Prof. S.C.C. Ting) and the University of Karlsruhe (contact person Prof. W. de Boer). Both institute s are interested in the search for the nature of dark matter. Dark matter is dominating the gravitational forces of the universe, but its nature is completely unknown. Investigating the nature of dark matter is the prime motive of a state-of-the-art detect or in space, the AMS-02 detector, approved by the NASA to be installed on the international space station in 2008. This detector will measure and identify all galactic charged particles and gamma-rays up to very high energies. MIT is the coordinating institute of this detector. In this OIF proposal the applicant would like to spend 24 months at MIT between 2005 and 2007 in order to get acquainted with space technology and all aspects of the detector, especially during the integration and testing phase. T he acquired knowledge will allow the home institute to become an expert on this detector, thus being able to analyze the data in detail and hopefully contribute to the discovery of the nature of Dark Matter. Furthermore the know-how obtained during this O IF could be useful for future space-born or ground-based experiments in the European Community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Unravelling the Interplay between Metabolism, Gut Microbiome and Adaptive Immunity in Amyotrophic Lateral Sclerosis'.

assistant: **Concept**

Amyotrophic lateral sclerosis (ALS) is a rare but devastating neurodegenerative disorder that in lack of effective treatments leads to death within a few years of diagnosis. ALS is increasingly being recognized as a systemic disease affecting not only the central nervous system but also other physiological aspects. We hypothesize that there is a disease-specific interplay between metabolism, gut microbiome and adaptive immunity, which substantially contributes to the etiopathogenesis of ALS. The overarching aim of this project is therefore to explore such interplay, and to assess the effectiveness of a treatment regimen that specifically targets it. Using a population-based case-control study of ALS in Stockholm, I will first characterize the complex interactions between metabolism, microbiome, and immunity in ALS, through comprehensive proteomic, metagenomic and immune-response profiling. The specificity of these interactions will be tested in contrast to healthy individuals at high risk for ALS (siblings), individuals with similar environmental and lifestyle factors (spouses), and unrelated population-controls. I will then use an established ALS mouse model (SOD1G93A) to understand the usefulness of combining a high-caloric diet with a fecal microbiota transplant from healthy human donors in disease prevention and treatment. To better understand the underlying mechanisms, I will compare microbiome and immune-response profiles before and after the intervention. The proposed research is unique as it 1) combines innovative molecular platforms with a high-quality epidemiological study design, 2) uses a novel strategy of investigating multiple aspects of human physiology, and 3) offers a possibility to directly translate findings between human observational and animal expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evolving increased vertebral counts: Developmental mechanisms underpinning phenotypic evolution in the Lake Malawi cichlid radiation.', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

One of the fundamental and most longstanding questions in biology is how phenotypes evolve to generate the incredible diversity of forms that surround us in the natural world. Vertebrate body shape is a good example of this, with species’ forms ranging from the rounded ocean sunfish to elongated snakes, and everything in between. The evolution of vertebrate body shapes has been accompanied by significant variation to the axial skeleton and the vertebrae that compose it, which can vary in size and morphology, but crucially also in number, ranging from less than 10 to several hundred. In COUNTS I propose an inter-disciplinary approach to uncover the developmental drivers of phenotypic diversity in vertebrates by using Lake Malawi cichlid fishes as a model system to investigate the evolution of increased vertebral counts.The diverse morphology, conserved genomes, close-relatedness, and ability to hybridise of these fishes makes them the ideal system in which to study how the evolutionary modification of developmental mechanisms has led to phenotypic diversity, in this case by evolving increased vertebral counts. The COUNTS project will combine state-of-the-art experimental embryology, single cell technologies, microscopy, and mathematical modelling to ask how developmental processes differ in three Lake Malawi cichlid species that have convergently evolved increased vertebral counts, and two that retain ancestral numbers. Specifically, we will characterise differences in two developmental processes known to play important roles determining total vertebral counts - gastrulation and somitogenesis - and use data-driven mathematical modelling to ask how these differences might have evolved. COUNTS will increase our fundamental understanding of how phenotypic diversity is gener
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Self healing innovative elastomers for dynamic seals, damping and noise reduction' in the context of a Seventh Framework call.

assistant: **Objectives**

Overall objective of the SHINE project is to develop a novel generation of elastomers that undergo spontaneous self-healing, leading to enhanced durability and reliability of the products made thereof (dynamic seals, shock absorbers, anti-vibration devices for vehicles, roads, railroads and bridges). The elastomers can heal without human intervention and can undergo multiple healing stages. They can prevent damage propagation by healing the microcracks or repair themselves in the case of accidental break. The objectives include also developing and standardizing test methods to quantify the efficiency and effectiveness of the self-healing process.The scientific and technical concept is based on the use of dynamic crosslinks both covalent and supramolecular (H-bonds and ionic interactions) that can be broken and reversibly reestablished to provide self-healing. Supported by the SHINE Exploitation Plan the new elastomers will be used to formulate, compound, manufacture and evaluate the final products as listed above. The results will be disseminated to initiate further research in this field.The products made by the self-healing elastomers will have prolonged lifetime, will increase reliability and enhance safety when used in vehicles, machinery and transportation infrastructure. The societal benefits are in reduction of roads incidents, injuries and fatalities, reduction in environmental pollution, and reduction of urban noise. The economic benefits include less road maintenance work, less traffic jams and waste of time associated with this, savings in energy and natural resources consumption, reduced machinery idle time due to frequent reparations, and reduced transportation costs, which will eventually improve the competitiveness of the European industry.A total of 574
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'AUTOMORPHISMS AND PERIODIC POINTS FOR MULTIDIMENSIONAL SHIFTS OF FINITE TYPE' under Seventh Framework.

assistant: **Concept**

Within the framework of Symbolic Dynamics, we propose to study the automorphisms of Multidimensional Shifts of Finite Type.We propose to explore certain algebraic invariants,  analogous to  the Dimension-Representation and the Gyration Numbers for automorphisms of one-dimensional Shifts of Finite Type.Our aim is to utilize the above invariants and confront certain natural problems related to these automorphisms: Extending an automorphism of a finite subsystem and generating an automorphism by  finite-order ``eventual automorphisms''.Our project has direct implications in the context of Multidimensional  Cellular Automata. Namely,  the existence of block representation for multidimensional invertible  cellular automata and the admissibility of a given set periodic orbits in a multidimensional invertible cellular automata.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Real algebraic and analytic geometry' in the context of a Fifth Framework call.

assistant: **Objectives**

The training programme of the network RAAG is designed to help its young members develop their technical skills as mathematicians, their managerial capabilities, and their social skills as members of a large community of individuals working towards a common goal. To achieve these goals, on the one hand the network will promote general European cooperation in the field of RAAG, taking care that young researchers participate in every activity; on the other hand it will make offers specially designed for the young researchers: Schools that present introductory courses, covering basic methods and techniques; meetings that bring young researchers together; publication of a lecture note series at graduate level, state-of-the-art introductions to the current literature; opportunities for visits and employment at other nodes of the network. The network will involve its young researchers in the organization and management of all its activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Deriving optimal promotion for increasing the share of res-e in a dynamic european electricity market (GREEN-X)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Currently no reliable dynamic promotion strategies exist, neither for a significant increase of RES-E, nor for an integration of RES-E into strategies for GHG-emissions reduction. The core objective is to achieve a continuous and significant increase in the share of RES-E with minimal costs to European citizen under various scenarios of liberalised electricity markets. This objective will be reached by creating the internet-based toolbox GREEN-X. It allows the extraction of minimum cost strategies (e.g. Tics, Feed-in tariffs, Green Pricing, emissions trading, CO2-taxes). The dynamics of costs and potentials for RES-E, CHP, conv. el. gen. and demand-side activities are considered. The main results will be:(i) a dynamic action plan for the EU as a whole and their Member States to meet this core objective,(ii) to help various stakeholders in deriving efficient strategies. Comprehensive dissemination activities will accomplish the work in this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Climatization of EU Policies: The Case of Maritime Transport'.

assistant: **Concept**

The objective of the research project titled Climatization of EU Policies: The Case of Maritime Transport (EU-CLIMT) is to explore in what ways climatization influences EU governance and impacts the power of the institutional actors. To do so, the case study of maritime transport will be employed, as it is one of the main policy areas indicated in the Fit for 55 package as crucial for the decarbonization of the European continent. In more detail, the project will analyze, first, the role of the supranational actors in promoting climate policies within the EU, with a focus on maritime transport; second, the implementation of the new green maritime transport policies by key stakeholders within the EU Member States; and, third, the impact of the said new policies on the EUs diplomatic positions at the international level and how these are perceived by third actors. The deliverables of the project will cover a broad array of outputs, such as scholarly articles, policy briefs, podcasts, seminars and public lectures, in order to ensure the maximum possible dissemination of the results. The project will be hosted at Leiden University.


**Keywords:** EU governance,  EU policymaking,  Climate policies,  Climatization,  Climate Diplomacy,  Maritime Transport Policies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Market Disruptive Pin Technology for Improving Heavy Machinery Operations and Safety'.

assistant: **Innovation**

BT produces patented customised pivot pins for uniting the joints of articulated heavy industrial machinery. BTPin expands to fill the joint bore and leaves no tolerance space for play or vibration.Zero tolerance space in the joint means BTPin suffers from no pin breaks, no mechanical jams, no ‘ovalling’ damage and no wear to the joint surface. It can function for at least a decade in heavy machinery and needs only occasional checks for tightness. Standard pivot pins last three years on average before breaking. BTPin can be scaled to fit a joint with diameters from 10mm to 500mm.End users benefit from mechanical reliability, zero pivot pin replacement costs, zero repair costs to ovalled joints, zero machine downtime caused by joint breaks, and lower risk of injury to personnel.In cash terms, BTPin costs €888 to purchase, install and maintain over a 12-year period. A comparable pivot pin in the same machinery over the same period costs €16,062.BTPin is compatible with all types of articulated heavy machinery, either in its manufacture or in retrofit upgrades. We have been commercialising our pivot pins to the offshore sector since the early 1990s. This Phase II allows us adapt, test and validate BTPin for onshore applications in mining quarrying, port cranes and construction. Our Phase I project (GA #774553) verified the market potential of BT for onshore applications, and a complete lack of competitors. Machine manufacturers could save €504,000 in OPEX costs, depending on the scale of their business. Port crane operators could save €31,500 per crane per day, mines €162,300 per day, and constructors €16,000 per site per day by using BTPin and avoiding downtime losses. BTPin belongs to the industrial fasteners market worth €68.1bn in 2017 and growing by 5% CAGR. BTPin wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Real-time Spectrographic analysis of melt pool composition for the generation of accurate functionally graded materials' (RETISPAN) under Sixth Framework.

assistant: **Objectives**

Direct Laser Deposition (DLD) allows smart components to be built directly under CAD control. It has great potential for next generation manufacturing. This includes Functionally Graded Materials (FGMs) in which composition across an interface is gradually altered, as in a biological system.The aim of this project is to investigate the possibility of real-time spectrographic analysis of the melt pool composition for the generation of accurate functionally graded materials. The proposed project will develop a process monitoring system for DLD applications.This project is divided into 6 major objectives:- Familiarization with laser equipment and different sensor systems during DLD process- Identifying different materials via spectral analysis- Incorporating analysis system into the laser deposition process- Testing for multiple component materials (alloys)- Experimental investigation for functional graded materials- Optimization of the DLD system.During processing the size/shape of the molten pool will vary, resulting in different levels of radiation. Any significant changes in the radiation intensity level may indicate potential failures of the process parameters. Thus, incorporating a high-resolution spectrometer into the DLD process would give significant information about the composition and accuracy.The deposition of FGM is a dynamic process and therefore requires a real-time, accurate method of material composition analysis. Current methods concentrate on stages either before or after the deposition process. The proposed method is intended to allow dynamic alterations of process parameters to ensure the desired material compositions are maintained.It is to be hoped that the process, when perfected, would also allow the real-time sensing of compositional irregulariti