RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mathematical aspects of evolving interfaces' (1998-2002).

assistant: **Concept**

Interfaces are geometrical objects modelling free or moving boundaries arising in a wide range of phase change problems in physical sciences, in particular, in material sciences. Recent mathematical advances in the analysis of geometric evolution problems, will be presented in a set of lectures with an interdisciplinary perspective, covering several aspects from theory and applications. This includes modelling, mathematical analysis and theoretical approximation.The topic has important recent developments and an increasing number of applications in a wide range of natural sciences, being a very active area of mathematical research, that is attracting an increasing amount of international attention. This is a very active current field of research for which it is necessary to train young scientists in Europe. The school is mainly intended for European postgraduate students, including recent PhDs, but not excluding selected participants from outside Europe nor senior scientists wishing to learn on the subject. The publication of lectures notes of the summer course is foreseen. This is jointly organised by the Portuguese CIM (Centro Internacional de Matemàtica) and the Italian CIME (Centro Internazionale Matematico Estivo).ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00221-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The moleculaR mEchAnismS Of dNa methylatIon reprogrammiNg in Arabidopsis sexual lineaGe' (REASONING) targeting Horizon Europe.

assistant: **Abstract**

In flowering plants, DNA methylation reprogramming occurs in meiocytes through RNA-directed DNA methylation pathway (RdDM) mediated by 24-nucleotide small interfering RNAs (siRNAs). My host lab discovered that these siRNAs are transcribed from transposable element (TE) in tapetal cells (tapetum) and transported to male meiocyte. In meiocytes, these siRNAs induce methylation at genes (MetGenes) with similar (but not identical) sequences, and thereby regulate MetGene expression and promote meiosis. The ability of siRNAs to target loci with reduced sequence homology is unique to meiocytes: in tapetum and somatic tissues, RdDM only targets TE with perfect sequence homology to siRNAs. The broad-targeting competence of tapetum siRNAs allows the targeting of MetGenes and fast-evolving TE in meiocytes, however, it is unclear how the broad targeting is achieved and comfined to the meiocytes. My preliminary work discovered several meiocyte-specific RdDM homologues, which I hypothesize to permit siRNA mismatch targeting. Furthermore, I found that RdDM mutants are hypersensitive to heat stress in meiocyte development, suggesting RdDM mediates heat stress response in meiocytes. Harnessing single-cell multi-omics, biochemistry and bio-imaging approaches, I aim to: 1) identity germline-specific RdDM homologues responsible for MetGenes targeting; 2) decipher how methylation of MetGenes are mediated by lncRNAs; and 3) uncover how the methylation reprogramming of MetGenes contributes to mediating male germline thermotolerance. My discoveries will elucidate essential siRNA regulatory mechanisms that mediate intergenerational heredity in plants and establish a novel epigenetic paradigm in how meiocytes perceive and respond to heat stress, essential knowledge for building crop resilience un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Intelligent augmented reality welding helmet' in the context of a Sixth Framework call.

assistant: **Objectives**

Welding is one of the most important industrial assembling methods. There are more than 45 million welders worldwide. A welding helmet shields the welders' eyes from radiation emitted by the welding arc but also restricts vision to the parts to be welded. This restricts control of the welding process. Augmented reality (AR) helmets will overcome these problems. Optrel is one of the leading manufacturers of welding helmets. An augmented reality helmet is thought to be the future for high end products.There is a significant technological risk in the development and marketing of such an AR helmet. The gap is wide between the principle knowledge about an AR helmet and a product which is acceptable to a welder esp. as Optrel has neither knowledge about augmented reality technology nor capacity in its implementation. Friedrich Wilhelm Bessel Institut (FWBI) is a research institute which bridges the gaps between basic research and application. It has experience in welding observation and AR helmets due to research projects VIOBES and TEREBES. FWBI was able to solve the basic research problems and show that technology is available for future welding helmets. Also the main drawbacks and opportunities have been identified. IntARWeld will be carried out by exchange of experienced researchers and RTD in the area of image processing, augmented reality, camera technology, user centred design, usability and productivity enhancement.With the expected research results new products will become available in the future. Within IntARWeld Optrel will send 3 experienced researchers to FWBI for research and ToK in the areas of image processing, camera optimization and AR. After their return they will be the core of a future RTD team established for research into augmented reality helmets. FWBI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mind the Gap: Learning, Teaching, Research and Policy in Inquiry-Based Science Education' under Seventh Framework.

assistant: **Concept**

The key concept of this project is inquiry-based teaching of secondary school science. Research and development done in Europe in the area of inquiry-based science teaching (IBST) is abundant, however, the knowledge is spread and indistinct, and thereby not utilised to its full potential by teachers and educators throughout Europe. The project aims to gather, exchange, develop and disseminate ideas of good practices in IBST.   The overall aim of Mind the Gap is to stimulate a more engaging and interesting science teaching based on principles of IBST so that more young people in general, and girls in particular, wish to pursue educations and careers in science and technology. We argue that if the science teaching shall succeed in meeting young people in their interests and concerns, we will need to examine and connect  • The gap between theory and practice in inquiry based science  • The gap between teaching and learning • The gap between research, policy and practice • The gap between educational policies and in-service training • The gap between instructional designs and preferable tools • The gap between cognitive demands and available tools  • The gap between the culture of science and marginalized groups (including girls)  The Mind the Gap project and network will focus on such gaps and aim to bridge them across different European contexts (Norway, Denmark, Germany, Hungary, United Kingdom, Spain, and France). The project design involves six work packages (WPs), including one management WP, each lead from different Europeans countries with relevant expertise. One of the WPs provides an overall background for IBST, three WPs go more in-depth into three specific themes (scientific literacy, ICT, and communication and argumentation). And the last WP will try out models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Deciphering the regulatory role of reactive oxygen species in plant ageing through an integrative genetics and genomics approach' in the context of a Seventh Framework call.

assistant: **Objectives**

Plant senescence is a genetically controlled process modulated by environmental factors. A number of genes that influence ageing have been identified over the recent years; while mutations in most of them accelerate senescence, some delay senescence and thus extend lifespan. Experimental evidence strongly indicates that many more genes than functionally characterized so far contribute to the control of plant ageing. Moreover, very little is currently known about how these genes interact and to what extent developmental signals, environmental factors, phytohormones, and in particular the circadian clock modulate their activity and interactions. Recent research shows that reactive oxygen species (ROS) play a critical role in the control of senescence. The aim of this project therefore is to uncover new elements of the ROS regulatory pathway that modulate senescence in Arabidopsis thaliana and to unravel the mechanisms by which these genes interact with each other and with the internal clock. Mutants with accelerated and delayed senescence, previously isolated by our teams, will be subjected to genetic, genomic, and biochemical analyses. Identification of the mutated genes causing the altered senescence, molecular analysis by RNAseq and qRT-PCR, proteome and metabolome profiling will help to understand how these genes regulate lifespan. Staff exchange is of crucial importance to the success of the project. The Bulgarian partner is an expert in ROS signaling, the German collaborator has expertise in transcriptional regulation of ROS-related genes, and the New Zealand partner brings in knowledge about the genetics and physiology of ageing and ROS - circadian clock interactions. Thus, the European and New Zealand partners mutually complement each other in their expertise and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Targeting glucocorticoid resistance in T-ALL: a Systems Biology approach' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer that accounts for 10% to 15% of pediatric and 25% of adult ALL cases. Glucocorticoids play a central role in the treatment of T-ALL due to their capacity to induce growth arrest and apoptosis in lymphoid progenitor cells. The development of glucocortioid resistance in leukemia patients is an important clinical problem and a significant contributor to therapeutic failure. Despite numerous studies addressing the mechanisms that mediate the response of lymphoid tumor cells to glucocorticoid therapy the mechanism of glucocorticoid resistance remain incompletely understood. Activating mutations in NOTCH1 are present in over 50% of T-ALL cases and aberrant NOTCH1 signaling can transform T-cell progenitors. Importantly, proteolytic cleavage by the gamma-secretase complex is required for ligand-mediated activation of wild type NOTCH1 and for aberrant NOTCH1 signaling in T-ALLs harboring activating mutations in the NOTCH1 gene and, small molecule gamma-secretase inhibitors can effectively block the function of oncogenic NOTCH1in T-ALL. Dr. Ferrando’s laboratory has recently shown that inhibition of NOTCH1 signaling with GSIs can reverse glucocorticoid resistance in T-ALL. Reversal of glucocorticoid resistance in this model is mediated by HES1 downregulation, increased glucocorticoid receptor autoupregualtion and improved glucocorticoid-induced upregulation of BIM, a critical proapototic factor, in glucocorticoid-induced programmed cell death. The identification of NOTCH1-HES1-glucocorticoid receptor regulatory axis in glucocorticoid resistant T-ALL serves as proof of principle for the main goal of this project, which aims to identify novel genes and pathways controlling glucocorticoid resistance in T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Setting Earth's Initial Conditions: A fluid dynamics study of core-mantle differentiation' under Horizon 2020.

assistant: **Concept**

The initial conditions of the Earth and other terrestrial planets were set 4.5 Gy ago during their accretion from the solar nebula and their concomitant differentiation into an iron-rich core and a silicate mantle. Accretion in the solar system went through several different dynamical phases involving increasingly energetic and catastrophic impacts and collisions. The last phase of accretion, in which most of the Earth mass was accreted, involved extremely energetic collisions between already differentiated planetary embryos (1000 km size), which resulted in widespread melting and the formation of magma oceans in which metal and silicates segregated to form the core and mantle. Geochemical data provide critical information on the timing of accretion and the prevailing physical conditions, but it is far from a trivial task to interpret the geochemical data in terms of physical conditions and processes. I propose here a fluid dynamics oriented study of metal-silicate interactions and differentiation following planetary impacts, based in part on fluid dynamics laboratory experiments. The aim is to answer critical questions pertaining to the dynamics of metal-silicate segregation and interactions during each core-formation events, before developing parameterized models of metal-silicate mass and heat exchange, which will then be incorporated in geochemical models of the terrestrial planets formation and differentiation. The expected outcomes are a better understanding of the physics of metal-silicate segregation and core-mantle differentiation, as well as improved geochemical constraints on the timing and physical conditions of the terrestrial planets formation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High fidelity quantum gates with trapped 43Ca+ ions' (43CAQIP) under Seventh Framework.

assistant: **Objectives**

We propose to create high fidelity quantum gates using qubits encoded in the hyperfine states of 43Ca+ trapped in a linear Paul trap. The use of magnetic field insensitive (m=0) states drastically decreases decoherence due to stray magnetic fields. We will investigate a number of entangling gates and set up simple error correction schemes. In particular, we plan to implement a number of quantum gates that rely on collective laser excitation of the ions. For this 43Ca+ offers the opportunity to use the narrow line width S-D quadrupole transition. This will make it possible to implement the collective laser excitation gate using magnetic field insensitive states, while greatly reducing decoherence due to spontaneous decay. These new types of quantum gates will be studied in this project in addition to quantum gate operations relying on Raman interactions mediated by a dipole transition. We expect the proposed research will provide an important step towards more demanding quantum computation. The fellowship will help to strengthen QIP research in the European Union while supplying ample opportunity for career development for the fellow.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'The Role of Monetary Institutions in an Economy with Heterogeneous Agents'.

assistant: **Concept**

Research objectives and contentThe objective of this research project is dual:i) firstly, to study a dynamical model of strategic games in the market place (JSM) with heterogeneous agentsii) secondly, the application of JSM market strategic games to financial markets.i) The idea is to locate the resource constraints in an economy with an overlapping generations model of static models. An economy with one god is considered here where the agents are differentiated by their endowments. Here we study the consequences on the constitution of stationary equilibrium and on the dynamics of the system. The question is to understand the relationship between the heterogeneity of agents and the properties of equilibrium.ii) Faced with this uncertainty, incomplete concurrencies market models have got a given market structure. I wish to apply this theoretical analysis to financial markets. In order to do this, it is possible to consider the Peck-Shell model (1989) and to explore it, in a static case, the reasons for inactivity in the market place. These reasons may be caused by the asymmetric distribution of information, and the narrowness of markets and also strategic interactions.Training content (objective, benefit and expected impact)Expected impact and benefits of the requested training:My main objective is to work with researchers working on monetary problems. We would work on confronting transactional and institutional monetary approach'sThis research project, which I am submitting is a further development of the work examined in my thesis. On the one hand a dynamical study of JSM and on the other hand a piece of theoretical research in a more applied sense. The possibility of spending one year at Universita degli Brescia would enable me to complete these objectives.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Single Chain Polymer Nanoparticles' in the context of a Seventh Framework call.

assistant: **Objectives**

The following proposal deals with the synthesis of single chain polymer nanoparticles from a supramolecular approach. To the date, collapse of random coil polymer is done through covalent cross-linking of the chain. In our approach, first we will synthesize block-copolymers with suitable functionalization. The methodology to obtain this block copolymer  will be thoroughly studied. Then, the different supramolecular units attached will promote, when triggered, the folding and collapse of a random coil into a well defined nanoparticle. The folding process will be studied with a large variety of techniques such as gel permeation chromatography, diffusion ordered-NMR or atomic force microscopy imaging. Moreover, we will try to control the folding process, as Nature do with biomacromolecules, in order to create well defined architectures. Finally, we will explore the potential applications of this new compartimentalized systems. Thus, catalysis might be one of the most challenging topics, due to folding promotes the existence of different environments to perform reactions. Other applications in the field of semiconducting materials or single-chain imprinting for recognition will be also envisaged.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'STRENGTHENING UKRAINE’S RESEARCH EXCELLENCE IN THE FIELD OF ANTIMICROBIAL RESISTANCE UNDER A ONE HEALTH APPROACH' (SURE-AMR) targeting Horizon Europe.

assistant: **Abstract**

SURE-AMR aims to improve the R&I capacities of IMBG to strengthen its scientific reputation, attractiveness and networking channels, while promoting scientific excellence in the field of antimicrobial resistance (AMR) under an One Health Approach (OHA). It aims to raise the level of excellence of IMBG to EU standards and to raise its profile nationally and at EU level through a sustainable framework for scientific and institutional capacity building, international collaboration and stakeholder engagement. The project will strengthen R&I and knowledge transfer through the development of targeted R&I study cases, training for IMBG researchers and IMBG staff, increased collaboration between academia, health sector and stakeholders with a general sustainable framework for research, international networking and a specific international mobility programme. Strengthening the experience of IMBG research staff, including a new generation of young scientists, will be achieved through the cooperation with EU partners with established scientific excellence in the topics and proven experience in economic impact and awareness raising and integration into national policies. At the scientific level, it is expected to enlarge the community of competitive and renowned researchers at IMBG in AMR, stronger and better connected to a core of international and relevant R&I systems, supported by skilled R&I managers with their international networks. At the social level, it is expected to improve the public health and environmental quality of Ukraine (and EU) through an OHA, while developing broader social systems appropriate to the Ukrainian context to face better prevention, analysis and mitigation of AMR. At the economic level, the project will contribute to the development of innovative pr