RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mechanistic modeling of the formation of bioactive compounds in high pressure processed seedlings of Brussels sprouts for effective solution to preserve healthy compounds in vegetables' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Health and quality of life of the European citizens is threatened by degenerative diseases with increased social and health care expenses. The health gains of food consumed are an important key to tackle this challenge; by developing new healthier food products or ingredients to be included in daily meals. In both cases, consumer acceptance is important and healthy bioactive compounds (BC) naturally present in food provide a solution to meet the consumer demand for natural components. Glucosinolates are such important BC found in many food commodities like cruciferous vegetables (CV) as Brussels sprouts and are linked to a reduced risk of cancer. However, they can undergo unwanted enzymatic degradation upon conventional processing, like heat treatment, and negatively affect the beneficial gain. Hence, this project will pave the way for effective solutions to meet the need for new bioactive food products. High Pressure (HP) has the potential to retain the intact glucosinolates in CV by providing a mild processing method for a controlled myrosinase inactivation (enzyme that degrades glucosinolates) not previously used in industry for CV. Sprouts of Brassica oleracea var. gemmifera will provide a well-defined homogenous matrix with a cell structure suitable for mechanistic studies at a molecular level and are selected as the model plant matrix (PM). This will provide new insight into the mechanism behind the HP impact on PM necessary for future HP application. The research objetives are: 1) To establish the HP parameters to control the activity of myrosinase on glucosinolate degrading, 2) To reveal the mechanistic effect on and control of myrosinase activity during HP, 3) To establish the mechanistic description of HP on enzymes and BC in plant cells based on 1) & 2). Expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Characterization of the gene and protein networks regulated by Staufen 2 in neurogenesis and their alterations in AD' (NEUROSTAD), addressing dissemination and exploitation.

assistant: **Impact**

Neurogenesis is a crucial process by which new neurons are formed in the brain through the conversion of Neuronal stem cells (NPCs). Altered neurogenesis has been identified in Alzheimer’s disease (AD), in both human brains and rodent models, yet the exact mechanism of the dysregulation is unknown.  Over the past few years, growing evidence indicates that RNA-binding proteins (RBPs) play a critical role to fine-tune neurogenesis and mediate cortical development in the mammalian brain. Among these, the RNA-binding protein Staufen 2 (Stau2) plays an important role during neurogenesis unbalancing NSCs maintenance and differentiation, which is critical for brain development and functions. Importantly, STAU2 protein has been shown to be downregulated in AD, suggesting a possible role of STAU2 in impaired adult neurogenesis in ADIn this project, I will use induced pluripotent stem cells in combination with single-cell transcriptomic methods to characterize the unknown gene and protein networks regulated by STAU2 in neurogenesis at the single-cell level and investigate their relationship to altered neurogenesis in AD. This work will provide a solid molecular knowledge about the role of Stau2 in neural differentiation and its impact in neurogenesis in AD. Furthermore, I will develop a pipeline for the study of RBPs in human diseases and I will acquire indispensable scientific skills to become an independent research in Europe Together, this study will provide a solid molecular knowledge of the role of RBPs in neural differentiation, enabling the development of new personalized medicine therapies, which is in compliance with the Horizon H2020 Health demographic change and wellbeing program.


**Keywords:** RNA-binding proteins, post-transcriptional regulation of the gene express
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'MultIwavelength LAser for fast DiagnOstic in biomedical and manufacturing applications' in the context of a Horizon Europe call.

assistant: **Objectives**

MILADO will provide a robust and universal technology platform for low-cost and large volume fabrication of mid infrared (MIR) lasers enabling novel sensors in medicine and production. Key innovation is the technology upscale of the epitaxy of Quantum-Cascade-Lasers (QCLs) on large area substrates and the development of concepts for direct III-V-epitaxy on silicon.Merging III-V and Si-photonics by integrating QCLs and Si-based MIR photonics using CMOS-based technology well-established but very costly III/V-technology-based manufacturing of QCL light sources for spectroscopic applications will be replaced by a cost-effective and scalable manufacturing technology on CEA’s CMOS Pilot Line bringing MIR technology out of its niche. Another building block of MILADO towards a general platform that can be extended for further integration of sensors and actuators in MEMS technology are MIR-PICs made from Ge/SiGe-structures for the definition of waveguides, combiners and any other passive devices required to handle the optical connection of QCLs. MILADO’s technology will open up new markets by enabling novel sensors for personal medical diagnostics or edge-sensors in chemical production. The versatility of the approach will be demonstrated in use cases covering process control and medical diagnostics reaching from the hospital to the patient covering waste anaesthetic gas detection, histopathology to biomarker monitoring.


**Keywords:** Quantum-cascade lasers, Heterointegration III, V on Silicon, CMOS processing, Mid infrared PICs, wearable medical devices, EdgeSensing, Large area QCL epitaxy, QCL growth on Silicon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European Hub for Contemporary China' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

China is a key global actor and a leading economic and technological power. Chinas increasing relevance in the geopolitical system, its various specificities, complexities and goals as well as its rapid evolution and new policy directions pose challenge to the EUs capacity to better understand contemporary China. Furthermore, the European Union needs to get to know and understand China on its own terms: not through the lens of other external sources but from its own European perspective.However, the European level expertise on contemporary China is often fragmented and difficult to access. To overcome this challenge, it is essential to connect established and emerging knowledge nodes as well as gathering, categorising, and mainstreaming their work on a publicly accessible platform. This approach will break down siloes and provide policy-makers, researchers, businesses, and civil society with the necessary knowledge to develop a comprehensive understanding of the various aspects that define contemporary China. Such an approach will also enhance the dissemination of information and facilitate the generation of new knowledge. In this regard, EuroHub4Sino project is built upon four interconnected and interdependent pillars that foresees (a) to develop a state-of-the-art digital platform which was absent in previous projects/initiatives as they had to rely on their own resources in their research/cooperation efforts. This platform will also better serve the wider civil society in mainstreaming independent European knowledge. An inclusive and diverse (b) network will make the most of the digital platform in its (c) collaborative research and communication activities. EuroHub4Sino has (d) developed an innovative and sustainable business model with an aim that this inclusive ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Molecular analysis of c-jun/nfat interaction', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The transcription factor AP-1 consist of a variety of dimmers composed of members of the Fos, Jun and ATF families of proteins. The activity of individual AP-1 components is regulated at multiple levels and participate in the regulation of a variety of cellular process including cell proliferation, apoptosis, differentiation and oncogenesis. Mice lacking c-Jun die at midgestation due to liver and heart defects. In addition to AP-1 proteins, c-Jun is capable of interacting with a number of proteins and form a heterotrimer, most notably with the Nuclear Factor of Activated T cells family (NFAT1-4). The binding of AP-1 and NFAT produce a strong coooerative complex cooperation between these unrelated families of transcriptions factors has been implicated in many biological processes in immune cells, but the role in extra-immune tissues remains to be understood. The objectives of this proposal is to clarify the importance of the AP-1/NFAT cooperation in lymphoid cells and to uncover novel biological processes dependent on c-Jun/NFAT interaction in extra-immune tissues, as well as, the requirement of the transactivation activity of c-Jun in these processes. I will generate two transgenic mices with the c-Jun allel mutated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Consortium Of Neuroimagers for the Noninvasive Exploration of Brain Connectivity and Tractography' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Nothing defines the function of a neuron better than it's connections"  (Mesulam)In the last two decades impressive advances in understanding brain function with new neuroimaging methods have been made, however to understand brain function, it is also very important to characterise its structure and connections.  The recent development of diffusion MR methods that map white matter tissue structure have lead to a renaissance in assessing brain connectivity. In comparison with the pioneering work of the XIX century neuroanatomists the new MR methods enable detection of white matter tracts in vivo.<br/>The aim of this proposal is to create atlases of the brains connectivity in different decades of life, to serve as a long-lasting reference for the neuroscience and medical community. Thus, we will be filling a critical need to complete the jigsaw by mapping comprehensively the connections and microstructure of the human brain.<br/>Diffusion MRI is the perfect technique to achieve this goal offering uniquely, as it does, myriad quantitative parameters through its very nature as a non-invasive virtual biopsy tool.  To reach this goal, synergistic integration of multidisciplinary teams is essential in order to develop, reform and refine, new methods for characterising microstructural and macrostructural connectivity assessments."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Good Jobs Economics: Incentives and Policies' in the context of a Horizon Europe call.

assistant: **Objectives**

Many advanced economies report low unemployment and tight labour markets yet continue to grapple with economic inequality and a scarcity of good jobs. A sizable share of workers remains stuck in low-paying positions with limited chances for career advancement. This research program examines multiple dimensions of good job creation, from the implications of part-time work to the influence of labour market institutions such as the minimum wage. It analyses whether workers fully account for the long-term consequences of part-time employment and discusses when governments should encourage or discourage these arrangements—especially given their potential to alleviate gender disparities in access to higher-paying positions. The program also explores the role of the European Union’s free movement of labour in expanding good job opportunities for Eastern European immigrants. Specifically, it investigates how Hungarian workers fare after migrating to Austria, focusing on wage progression and skill development—both for those who assimilate and those who eventually return to Hungary. Another central component explores the role of a prominent labour market policy, the minimum wages, in fostering good job creation. While higher minimum wages can boost pay, they may also restrict career growth and flatten wage trajectories for low-wage workers. By weighing these benefits and drawbacks, the research will gauge the overall contribution of the policy to good job creation. To achieve these objectives, the program draws on newly gathered survey data and previously untapped administrative sources, leveraging significant policy variations and cutting-edge empirical approaches. Ultimately, it aims to untangle the forces behind good job creation—those that offer meaningful career progression
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Organic Reactivities in BioRenewable Solvents' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Reactivity studies for organic reactions have so far mainly been done in classical organic solvents (dichloromethane, acetonitrile, DMSO) which need oil or gas as feedstock, are hazardous and cause problems with the waste treatment.  Given that almost all organic synthesis protocols need to be revised in a post-oil/gas era, non-toxic sustainable-by-design solvents which are based on renewable, plant-based raw materials will rapidly gain importance. Without reactivity data, however, an informed re-design of organic synthesis is impossible. ResolveByBio will deliver the data for defining the scope of electrophile-nucleophile reactions in biobased solvents, which will be used in the future. EU-located chemical suppliers have recently started to commercialize some of these biobased solvents. Though they have been considered expensive, the steep increase of prices for oil&gas-based chemicals makes them more and more attractive. Once established, scaling effects will make bio-based solvents strong price competitors of conventional solvents. However, these bio-based solvents are still awaiting broader acceptance in academia and commercial chemical applications. Integrating them in the currently most comprehensive reactivity scales (Mayr's Database of Reactivity Parameters) will foster their applications and significantly contribute to reducing the negative impacts of chemistry research and businesses on the environment. Thus, the data generated by the proposed project will deliver important building blocks for the conversion of the EU chemistry towards reaching the goals of the EU Green Deal by empowering chemists with the some of the most fundamental data that are required to change chemical processes.


**Keywords:** Linear free energy relationships, nucleophiles, electrophi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European investigations on daphne and other international collider experiments using effective theories of colours and flavours for high precision elementary particle physics from the phi the upsilon.' (EURIDICE).

assistant: **Concept**

The network will offer 302 person-month for training of young researchers, 48 of which for doctoral students, the remaining post-doctoral positions. The young researchers will work with scientists who have been collaborating across national borders for a number of years, and will receive training in the field covered by the scientific objectives. They will present their work at the topical workshops organized by the network and at the Collaboration meeting organized every year at different locations around the network. All the young researchers will be expected to attend the yearly LNF Spring School, organized by the Coordinator of the network, with world experts lecturing on timely and topical subjects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Conformal coating of nanoporous materials' under Seventh Framework.

assistant: **Concept**

CONTEXT - Nanoporous structures are used for application in catalysis, molecular separation, fuel cells, dye sensitized solar cells etc. Given the near molecular size of the porous network, it is extremely challenging to modify the interior surface of the pores after the nanoporous material has been synthesized.THIS PROPOSAL - Atomic Layer Deposition (ALD) is envisioned as a novel technique for creating catalytically active sites and for controlling the pore size distribution in nanoporous materials. ALD is a self-limited growth method that is characterized by alternating exposure of the growing film to precursor vapours, resulting in the sequential deposition of (sub)monolayers. It provides atomic level control of thickness and composition, and is currently used in micro-electronics to grow films into structures with aspect ratios of up to 100 / 1. We aim to make the fundamental breakthroughs necessary to enable atomic layer deposition to engineer the composition, size and shape of the interior surface of nanoporous materials with aspect ratios in excess of 10,000 / 1.POTENTIAL IMPACT Achieving these objectives will enable atomic level engineering of the interior surface of any porous material. We plan to focus on three specific applications where our results will have both medium and long term impacts:- Engineering the composition of pore walls using ALD, e.g. to create catalytic sites (e.g. Al for acid sites, Ti for redox sites, or Pt, Pd or Ni)- chemical functionalization of the pore walls with atomic level control can result in breakthrough applications in the fields of catalysis and sensors.- Atomic level control of the size of nanopores through ALD controlling the pore size distribution of molecular sieves can potentially lead to breakthrough applications in mole
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Statistical Thermodynamics and Computer Simulations of Complex Molecules in Bulk and at Surfaces' to be submitted under Seventh Framework.

assistant: **Abstract**

The aim of the project is to perform advanced theoretical and computer simulation studies of nonuniform fluids involving complex molecules. It comprises of three work packages: (i) fluids in contact with tethered layers formed on surfaces and in pores, (ii) substrate driven self-assembly of supramolecular structures formed by complex organic molecules, and (iii) substrate induced self-assembly of nanoparticles with chemical dichotomy.The first work package will involve research of thermodynamic properties and microscopic structures of fluids in contact with a single surface and in pores with walls modified by tethered brushes. We intend to study how these properties depend on the molecular parameters of the model, as well as on thermodynamic variables. We plan to perform studies at different levels of modeling of tethered brushes, from molecular to coarse-grained models, and apply different theoretical tools (density functional theory, molecular dynamics and dissipative particle dynamics simulations).The goal of the second work package will be to study the surface-induced self-assembling of Liquid crystalline dendrimers (LCDr) into bulk as well as surface phases.We will develop a range of surface potentials and study the surface driven self-assembly  into monolayer and thin films. Then, we shall investigate the surface induced assembly of liquid crystalline dendrimers into bulk phases in wide slit pores and in the cases of the surface anchoring frustration.The third work package involves studies of behavior of Janus particles in the bulk and at surfaces. In particular, we plan to determine the structure and phase behavior of self-assembled phases of simple dichotomic (Janus) molecules. Then, we shall investigate  transport phenomena in self-assembled fluid nanostructure