RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New T cell signaling pathways.' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

In the immune system, T cells develop their antigen-specificity in the thymus by acquiring a functional T cell receptor (TCR) which triggers intracellular signalling regulating selection, activation and proliferation. The adaptor molecule LAT is functioning as a scaffold protein in a key signalling node of the T cell receptor signalling pathway. Accordingly, mice deficient for LAT or expressing loss-of-function LAT mutants show a dramatic impairment in T cell development. Surprisingly, when a constitutively active form of the tyrosine kinase Lck is expressed in those LAT mutants, the block in T cell development is reverted and some mature T cells are produced, bypassing the need for LAT. Therefore, the first objective of this proposal is to elucidate new LAT-independent pathways used during T cell development by a differential proteomic approach. Various loss-of-function LAT mutations have also been shown to differentially affect alpha-beta versus gamma-delta T cell development.To better understand the parallel development of those two T cell populations, the second objective of this proposal is to follow the early steps of alpha-beta T cells development by tagging the nucleus of beta-chain-expressing cells with a red-fluorescent protein. This will allow in vivo monitoring of alpha-beta T cells in the thymus and in peripheral tissues simultaneously to gamma-delta T cells which are tagged in green in a mouse model engineered in Bernard Malissenas laboratory. Being a Canadian woman with an excellent background in biochemistry, enzymology, apoptotic processes and brain development, joining the laboratory of Bernard Malissen, a world leading group in in vivo studies of the immune system, will favour knowledge and technical transfer in both directions as well as the developm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The first real-time monitoring device able to determine the impact area of space vehicles’ fragments during re-entry into the Earth’s atmosphere and minimize risks for people and property' (DeCAS), addressing dissemination and exploitation.

assistant: **Impact**

In the last decade the space debris issue is being in the spotlight, with more than 13,000 artificial objects currently orbiting around the Earth, including almost 1,700 operating satellites, most of which are destined to re-enter the atmosphere and hopefully burn out. Unfortunately, on average 10-40% of satellite mass survives re-entry and impacts the Earth’s surface, posing serious hazard to both people and their property. The increasing risk led space agencies to impose progressively stricter regulations, but currently it is impossible to precisely predict the impact area of surviving fragments. In case of high perceived risks, authorities are forced to close large airspace supposedly concerned, with costs in the range of several millions. Aviosonic has developed and patented DeCAS, a small “black-box” device that is mounted on satellites and allows to track and model in real time the trajectory of the fragments and their impact area. DeCAS will enable safety agencies to be promptly notified about potential danger for people or property, with a highly precise overlay map of the dangerous area. The DeCAS system is directed to satellite operators/manufacturers, so as to significantly reduce risks associated to the re-entry phase, support them in being compliant with space agencies’ regulations, and reduce the high insurance premiums similarly to black boxes in the automotive sector. The DeCAS system has been tested during the D-SAT space mission in 2017, thus validating the software functionalities and performances. During Phase 1, we will define the most suitable hardware components to assess the compliance with market requirements. We will also consolidate the business model and perform a cost-benefit analysis so as to quantify the economic savings for the customers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Uncovering the creative process: from inception to reception of translated content using machine translation' under Horizon Europe.

assistant: **Concept**

The new machine translation paradigm, neural machine translation, has drastically changed society’s perception of technology and the act of translation. It has also motivated a series of claims by research labs and the media implying that machines will soon decode the transfer of one language to another, thus driving professional translators out of their jobs. Creative content producers, such as streaming platforms or publishing houses, are now exploring, testing or using neural machine translation. Yet little is known of the constraints this technology poses to translators’ creative process and how such constraints impact the users. The need to understand this has become essential to sustain translation richness, translators’ job satisfaction, authors’ and directors’ reputations, and the user experience.INCREC aims to uncover the creative stages of professional translators to understand how technology can be best applied to the translation of literary and audiovisual texts, and to analyse the impact of these processes on readers and viewers. The research project is articulated in four work packages that cover two broad areas: inception and reception of literary and audiovisual translation. To better understand this complex process, INCREC triangulates data from eye-tracking, retrospective think-aloud interviews, translated material, and questionnaires from professional translators and users.Thus, INCREC develops a new theoretical framework that encompasses a) creative stages in translation, b) classification and mapping of translation problems which require a higher level of creativity and cognition, as well as a classification of the solutions to these problems c) understanding how machine translation is most effectively used during this creative process, and d) under
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Highly functional and chemically defined hybrid supramolecular hydrogels for organoid culture and multi-technology bioprinting (HYBRIGEL)' to be submitted under Horizon Europe.

assistant: **Abstract**

There is a growing need for reproducible, human-relevant in vitro models to advance biomedical research and drug discovery. Current 3D culture systems often fail to replicate the complexity of native tissues, contributing to poor clinical translation rates and limiting the development of animal-free testing platforms. While organoid technologies and biofabrication methods offer promising solutions, their progress is constrained by the lack of standardized, scalable biomaterials. Widely used matrices such as Matrigel, derived from laminin-rich tumor extracts, suffer from batch variability, undefined composition, and poor compatibility with advanced manufacturing techniques. Building on my ERC-funded VOLUME-BIO project, we have developed HYBRIGEL, a novel, chemically-defined hydrogel designed to address these limitations. HYBRIGEL is based on abundantly available gelatin, modified with reversible supramolecular interactions in addition to covalent crosslinking. This creates a dynamic, cell-responsive environment that promotes tissue remodeling, cell migration, and mechanotransduction—without requiring additional bioactive peptides. HYBRIGEL supports diverse cell types, including organoids, mesenchymal stem cells, vascular cells, and T cells. HYBRIGEL’s enhanced mechanical stability allows for the creation of complex, biomimetic structures through biofabrication techniques such as volumetric bioprinting. Its reproducibility, scalability, and manufacturing efficiency position it as a strong candidate for widespread adoption in both research and pharmaceutical applications. This project will advance HYBRIGEL towards commercial exploitation by expanding its validation across multiple organoid types and demonstrating scalable production processes. A comprehensive market analys
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Identification of Risk Factors for the Development of Diabetic Nephropathy: The PREDICTIONS Project' (PREDICTIONS) targeting Sixth Framework.

assistant: **Abstract**

Diabetic nephropathy (DN) is one of the most severe and life-threatening complications of diabetes mellitus. About 30% of patients with type 2 diabetes will eventually develop DN. Duration of diabetes as well as glycaemicand blood pressure control do not s ufficiently explain the risk of developing DN. About 31 genes have been reported to possibly contribute to DN susceptibility. A major susceptibility gene was mapped to 18q and a sequence variant in the CNDP1 gene was identified to cause a 3-fold elevated risk of DN. On the proteomic level, protein modifications by advanced glycation end-products (AGEs) are known to be sufficient to cause DN. AGEs are closely linked to reactive oxygen species (ROS) production. Different variables promise to have the poten tial of serving as biomarkers with high predictive value for DN risk assessment. To achieve the goals of the programme calling for identification of pathophysiological relevant genes and biomarkers correlated with onset, progression and response to therapy of DN, the project focuses on prospective research and case-control studies to: - Systematically re-evaluate available genetic data - Perform functional genomics for studying effects of gene variants - Study the influence of AGEs, ROS and carnosine a nd further predictive biomarkers. The latter will be realized both on the genomic (expression profiling in kidney biopsies) and proteomic level (mass-spectometry). In 3 multivariate analyses these markers will be correlated with the success of treatment wi th ACE inhibitors, irbesartan, and benfotiamine. A risk model will be developed for use by clinicians, who will evaluate the model prospectively in the future. This proposal will have significant impact on patient care. It is expected to provide scientif ic evidence f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Targeting challenges of active ageing: innovative integrated strategies for the healing of age-related hearing loss' in the context of a Seventh Framework call.

assistant: **Objectives**

Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need.The TARGEAR project is constituted by experienced research groups in complementary fields ranging from the molecular to the clinical aspects of age-related hearing loss. The general objective is to develop a collaborative strategy between public research centres and private companies, based in transfer of knowledge, to design and implement preclinical studies for presbyacusis. A second general objective is to contribute to the formation of early-stage researchers in the experimental design, transfer and translation of knowledge in the field of hearing loss.It is essential for Europe future aged population to have well-trained people available to understand hearing loss from a general perspective. According to this, the foreseen secondments and training activities will involve a total of 15 experienced and early-stage researchers.In the end, TARGEAR project will develop a stronger biomedical research in hearing loss for a better future for the deaf people.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Water analytics and Intelligent Sensing for Demand Optimised Management' (WISDOM), addressing dissemination and exploitation.

assistant: **Impact**

Growing water demand caused by climate change, urbanization and population growth requires new business and technology platforms to manage the increased level of diversity and complexity of urban water resources management. The increasing variability of both supply and consumption will also require more sophisticated and optimized decision making.<br/>To achieve a step change in water and energy savings we propose to apply and test an intelligent ICT system for real time abstraction & discharge monitoring". This will create an open, scalable, marketable and user-friendly system to optimise water resource management and replace the current licensing system. An innovative "just-in time" ability will be applied to create substantial water savings, whilst also enhancing delivery on EU Water Framework Directive obligations.  The WISDOM approach will combine different innovative technologies (including smart ICT components and decision support system) to integrate water distribution, real time sensor monitoring and high power computing networks to (a) improve household, business and societal awareness, (b) induce changes in consumer behaviour, (c) enable the introduction of innovative resource and demand management schemes, (d) pave the way to adaptive pricing incentives, and (e) develop and demonstrate widely applicable concepts for energy recovery from water use, enhancing the water-energy nexus.<br/>The WISDOM project strategy fundamentally relies on a comprehensive R&D and demonstration approach. The proposed integrated concept will be first modelled and simulated for different typologies of buildings and water distribution network, then tested at an intermediate level in a full-scale experimental facility in France (AQUASIM) before being finally installed, monitored and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Second life of wood: BioFlex technology to dissolve waste wood to get raw materials' (Bioflex).

assistant: **Concept**

We have developed the BioFlex solvent process that uses contaminated and/or unwanted waste wood as a very cheap raw-material to produce clean and high-quality inputs for the production of renewable chemicals, fuels and materials. A simple chemical process separates the main components of wood: cellulose and lignin. These can then be turned into final products such as bio-plastics, common chemicals and novel materials. There are a variety of new value chains that are potentially created through our technology. For example, using the waste wood from a local council, cellulose can be isolated, which is hydrolysed, fermented to succinic acid and then used in paint. The lignin isolated alongside the cellulose can be turned into a drop-in biodiesel sold at the local petrol station. Similarly, sawdust from a timber mill can be fractionated, the cellulose used to produce methylcellulose as a thickener in food, the lignin turned into a bio-derived plastic.We are diverting wood waste from going to landfill or incineration and sawdust going into pellets. The European pellets market is saturated, also with pellets imported from the Americas. The lignin and cellulose produced from these currently underused wood resources can enter new, emerging, or existing value chains. Our competition on the waste wood disposal side is incineration, offering energy recovery in some cases but resulting in the formation of toxic ash and contributing to air pollution. For some heavily treated waste wood there are no competitors except for costly and highly undesirable landfilling which are largely viewed as problematic by both waste producers and waste managers.The market is estimated to be EUR 40.9 billion for BioFlex made cellulose and EUR 13.4 billion of waste wood recycling. We have established a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Bayesian Learning in the Infant Brain' to be submitted under Horizon 2020.

assistant: **Abstract**

Infants come into the world equipped with amazingly powerful learning competences. The past decades have witnessed an ever-growing series of discoveries about young infants’ early cognitive achievements, illustrating these fast and unique adaptive abilities. However, the brain bases of learning mechanisms in the developing brain remain poorly understood. Meanwhile, in the past decade, the Bayesian brain has been put forward as a promising computational model accounting learning processes in the mature adult brain. In the present project, I propose to bring the two communities together and inspect the validity of the influential Bayesian brain hypothesis when learning processes are most crucially shaping the brain. Two assumptions derived from the Bayesian theory will challenged with studies conducted in young infants, using non-invasive behavioral and brain imaging techniques. In a first study, I will inspect whether the infant brain actively propagates predictions about upcoming events, as hypothesized in the Bayesian framework.  In a second study, I propose an integrated application of computational modeling, neural recordings and behavioral measurements to test a second assumption of the Bayesian brain which postulates that the brain continuously tracks and adjusts to the progressive discovery of regular patterns in the input. I will establish an international research network and rely on two hosts with distinct expertise to provide me with new skills. By bridging multiple levels of description, this research program will open up translational perspectives for the understanding of developmental processes and ultimately for the diagnosis of atypical development.


**Keywords:** brain imaging, brain development, learning, prediction, attention
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Advanced Asic cores for OFDM communications' (ADOC) under Fifth Framework.

assistant: **Objectives**

ADOC puts together reusable innovative ASIC ?ores that go beyond the state of the art for OFDM-based Communications. The cores will be used in a family of integrated circuits that are based on the state-of-the art OFDM technology, including chipsets for high-speed Powerline Acces modems, high-speed Powerline LAN cards, VDSL and Wireless Local Loop. The library of cores will be integrated in the design flow so that the productivity of the design teams is highly increased. Once the prototypes have been finished and validated in laboratory test, they will be evaluated at different 'real-life' scenarios in order to determine the fulfilment of the specified requirements. In order to develop a channel model suitable for the IP Cores development, the Channel characterization of the Medium Voltage lines will take place. High- speed transmission through the MV network will enable a very cost effective deployment of technology.OBJECTIVES The technological objectives of the proposal are the development, test, validation and documentation of following reusable ASIC Cores that go beyond the state of the art, as justified in Part B of this proposal: - 2048-carriers OFDM- Point to Multipoint Core- Power Line Bridge - 802.1d MAC Bridge - USB Full Speed Physical Transceiver- 80 Msps 10 bits DA Converter- 80 Msps 10 bits AD Converter- High Frequency Lineal Bandpass analogue filters- Low Noise Amplifier - Ultra-low distortion Programmable Gain Amplifier- High-current/low-distortion Line Driver.DESCRIPTION OF WORKThe project starts with a requirements definition, going from the market requirements, through the system specification, to the specific core requirements. At this stage, the medium voltage (MV) network has to be studied and characterized in-depth in order to be able to develop a