RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Agent-based Distributed Decision Support System for brain tumour diagnosis and prognosis'.

assistant: **Innovation**

The diagnosis and treatment of brain tumours is typically based on clinical symptoms, radiological appearance and often a histopathological diagnosis of a biopsy. However, treatment response of histologically or radiologically similar tumours can vary widely, particularly in children. Magnetic Resonance Spectroscopy (MRS) is a non-invasive technique for determining the tissue biochemical composition (metabolomic profile) of a tumour. Additionally, the genomic profile, determined using DNA micro-arrays, facilitates the classification of tumour grades and types not trivially distinguished by morphologic appearance. We argue that this new information for classifying tumours along with clinical data should be securely and easy accessible in order to improve the diagnosis and prognosis of tumours. All data will be stored anonymously, and securely through a network of Data Marts based on all this information acquired and stored at centres throughout Europe.This network will grant bona-fide access to an organisation in return for its contribution of clinical data to a distributed Data Warehouse (d-DWH)/Decision Support System (d-DSS). An ad hoc agent-based architecture will negotiate a distributed diagnostic tool for brain tumours, implement data mining techniques, transfer clinical data and extract information. The distributed nature of our approach will help the users to observe local centre policies for sharing information whilst allowing them to benefit from the use of the d-DWH.Moreover, it will permit the design of local centres targeting a specific patient population. We will form a consortium encompassing a wide range of talent from Universities, SME and Hospitals. The d-DWH/d-DSS, the MRS installed base and the expertise of the consortium will provide the foundations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A revolutionary digital therapeutics platform for personalized and effective neurocognitive rehabilitation'.

assistant: **Concept**

Cognitive impairment causes decline in cognitive abilities, including memory and thinking skills. It is fast growing, and affects around 450 million people globally. The major causes of cognitive impairment are Traumatic Brain Injury (TBI), stroke, ageing, depression, anxiety and Attention-deficit/hyperactivity disorder (ADHD). Cognitive rehabilitation is a program to help brain-injured or otherwise cognitively impaired individuals to restore normal functioning, or to compensate for cognitive deficits. Nevertheless, the overall rehabilitation efficacy is surprisingly low (about 5%), even for patients with mild conditions. Multiple studies indicate that this stems from insufficient recruitment of patients’ brain engagement to the therapy. BE Therapy is a revolutionary digital therapeutics platform for personalised and effective neurocognitive rehabilitation. It consists of a wearable EEG device and a patient management system. During cognitive therapy, BE Therapy proprietary algorithms capture real-time brain engagement from EEG data. The patient management platform then autonomously adjusts the therapy to be most effective to the patient, maximizing brain engagement and dramatically improving cognitive therapy efficacy. This personalisation can be tweaked or supervised by an onsite or remote physician. Digitisation of the platform enables to optimise session frequencies and increase availability to serve more patients, thus maximising public health care system resources. Being a home-point-of-care solution, it reduces the costs and time associated with the rehabilitation.During the phase 1 feasibility study, Brainmarc will establish a sound go-to-market strategy and supply chain, and will outline further development plans. In the second phase of the innovation project,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'PILOT PROJECT FOR A SMALL SCALE SOLID FUEL CHP PLANT [PART 1]'.

assistant: **Objectives**

AIM IS TO DEMONSTATE SOLID FUEL CHP WITH DISTRICT HEATING BY REPLACING HOT WATER BOILER WITH SMALL MULTI-FUEL HP STEAM BOILER AND EMPLOY A BACK PRESSURE TURBINE. THE PROJECT IS BASED ON GASIFYING BIOMASS FUELS IN AN EXISTING DESIGN OF GASIFIER [DEVELOPED IN EU STEP-CT 91-0129] CLAIMED TO BE CAPABLE OF UTILISING WOOD CHIPS, PEAT AND COAL AND BURNING GASES IN A REDESIGNED BOILER. AN EXISTING DH SCHEME IS TO BE USED AND ITS BOILER PLANT UPRATED FIVEFOLD TO PRODUCE 1MWe+5MWth. NEW GAS TRANSFER PIPE CLEANING SYSTEM WILL BE INCORPORATED ALSO BOILER SURFACES WILL NEED TO BE KEPT CLEAN.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Action for low weight automotive technologies' (FLOAT).

assistant: **Concept**

FLOAT PROJECT OVERVIEW The purpose of the network is to integrate efforts towards producing low weight automobiles. Previous efforts have primarily concentrated on investigating alternatives for reducing the weight of the automotive body structure. This network will link those past efforts with the current project activities looking at reducing the weight of bolt-on components, interior components and underbody components. There are a number of questions that need to be answered before light alloy component (raw materials and manufacturing), dynamic performance at reduced weight and thickness, consistency and durability. This network includes projects covering these aspects for aluminum and magnesium including manufacturing processes and corrosion performance. The main strategic objectives for the network projects are: * Significant weight savings * Improved performance including durability * Cost effective new materials and processes * Reduced energy processing * Environmental improvements * Design parameters for low weight components The primary role of the network is to establish suitable materials and their conditions, relevant manufacturing techniques for different applications, a techno-economic analysis of the possible combinations to establish a matrix of possibilities and a validated virtual concept for a low weight vehicle. The most cost effective and potentially most acceptable solutions for the automotive industry and it's customers will be established. The ultimate aim of the matrix would be to develop a low weight scenario with precise targets in terms of reduced weight automotive components and then to link that to the beneficial effect that has on the environment. EUROPEAN DIMENSION AND PARTNERSHIP This network has participants from seven EU countries in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Scientific basis for tungsten and tungsten alloys tailored for electron beam additive manufacturing' (ElectronsMatter), addressing dissemination and exploitation.

assistant: **Impact**

The ElectronsMatter MSCA Doctoral Network addresses critical challenges in the additive manufacturing (AM) of tungsten and tungsten alloys, a field crucial for advancing applications in energy, aerospace, and green technologies. Tungsten, with its exceptional properties such as the highest melting point of any metal and excellent resistance to wear and corrosion, is ideal for extreme environments. However, its high melting temperature and brittleness make it difficult to process using conventional methods, limiting its industrial use.This project leverages electron beam powder bed fusion (PBF-EB), an AM technology with unique capabilities for processing refractory materials like tungsten. By combining computational modeling, advanced characterization, process design, novel in-process monitoring methods, and mechanical behavior analysis, ElectronsMatter aims to develop optimized strategies for manufacturing dense, crack-free tungsten components with complex geometries. The network will tackle key challenges such as defect formation, microstructure evolution, and process monitoring, driving innovations in AM and materials design. Furthermore, material reusability will be studied, enhancing the sustainability of the process. ElectronsMatter integrates the expertise of leading academic and industrial partners to train a new generation of materials scientists. Doctoral Candidates will benefit from interdisciplinary research, industrial secondments, and cutting-edge training in sustainability, innovation, and advanced manufacturing. This aligns with the MSCA Work Programme by fostering skills for the green and digital transitions and strengthening Europe’s competitiveness in sustainable manufacturing technologies.By addressing the technical, environmental, and societal challe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Mechanistic studies and properties of galactose oxidase'.

assistant: **Concept**

Research objectives and content Galactose Oxidase is a single copper enzyme from the Canadian woodrot fungus Fusarium dendroides. It oxidises/degrades primary alcohol, sugar/polysaccharide substrates to aldehydes, and is re-oxidised by oxygen with release of hydrogen peroxide. The structure has recently been determined and mechanistic studies are timely. To better understand substrate binding to copper, reactions with azide, thiocyanate and phenols will be studied. The copper will be replaced by other metals enabling the second redox component (a tyrosyl radical) and other features to be studied in what is a unique active site. Interesting thermochromic changes for Galactose Oxidase, an auto-redox interconversion taking 3h, the determination of reduction potentials by direct electrochemistry, and reduction of Galactose Oxidase with phenylhydrazine will also be investigated. Training content (objective. benefit and expected impact) Previous research has been in generating and studying phenol ate radicals in metal complexes as models for enzymes. There have been no opportunities to work on enzymes. Professor Sykes' group has extensive experience with metalloproteins, Galactose Oxidase being a recent additional interest. This is an excellent opportunity to gain experience isolating and handling a free-radical containing enzyme in an important developing research area. Links with industry / industrial relevance (22) Professor Sykes' group has Ph.D. student support/collaborations with Unilever Research for work on Galactose Oxidase.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Anti-inflammatory cytokines in neurological disease: Mechanisms and therapeutic potential' under Fourth Framework.

assistant: **Concept**

The overall objective of this project is to test the hypothesis that cell death in the central nervous system is critically dependent on the balance between pro-inflammatory cytokines such as interleukin-1, and anti-inflammatory cytokines such as the interleukin-1 receptor antagonist, interleukin-4, interleukin-10 and interleukin-13. For this purpose, the participating laboratories will :assess whether experimental insults which lead to brain damage modify the brain expression of anti-inflammatory cytokines in a regional and temporal manner; determine the contribution of these anti-inflammatory cytokines to brain insults, by experimentally modifying expression and action of these molecules in well defined model systems; investigate the way anti-inflammatory cytokines interfere with the synthesis and actions of interleukin-1 in the brain. Using standardized reagents produced by a Centralized Facility, the participants will study the expression and action of anti-inflammatory cytokines in several animal models of brain inflammation, which differ by the severity, time course and cell types responsible for the local production of these molecules (brain resident cells or invading blood cells). These animal models include a model of acute non-immune brain inflammation (systemic administration of lipopolysaccharide), a model of acute brain trauma (lateral fluid percussion on the cortex), a model of chronic non-immune-mediated neurodegeneration (cerebellar mutant mice), and a model of chronic immune-mediated brain inflammation (the delayed-type hypersensitivity response to bacillus Calmette Guerin). For each of these models, standard animals and transgenic animals with an overexpression or a decreased expression of anti-inflammatory cytokines will be used. The investigation of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Staphylococcus aureus sRNA targetomes and regulatory networks involved in fast adaptive responses: structure, mechanisms and dynamics'.

assistant: **Objectives**

Staphylococcus aureus is an opportunistic human pathogen responsible for severe nosocomial and community acquired infections. S. aureus has evolved a large number of strategies to regulate the synthesis of multiple virulence factors including the use of small regulatory RNAs (sRNAs). These sRNAs in combination with transcriptional regulators adapt cell growth in response to various stresses and environmental conditions. Hence, the identification of sRNAs regulatory networks is of crucial importance in the fight against emerging multidrug resistant strains. Using recent and innovative technologies (i.e. MS2-affinity purification coupled with RNA sequencing and ribosome profiling), we will investigate biological roles of sRNAs, elucidate their targetomes, and their mechanisms of action that was not possible to obtain with classical genetic and biochemical approaches. This project is aimed to draw comprehensive sRNA regulatory networks, which may contain many new targets regulated by unexpected mechanisms and unravel the deepest mysteries in sRNA field in this major opportunistic pathogen. Finally, sRNA-mediated regulation dynamics will be analyzed with unprecedented scrutiny in single-cell studies. The recent development of techniques to visualize RNA and to monitor gene expression in individual bacterium, offer the possibility to address specific questions related to the dynamics of sRNA regulation. Proposed single cell studies will be crucial to investigate the dynamics of sRNAs-dependent regulation, but also to monitor its impact on a monoclonal population behavior in response to a particular stress. Such analysis will open long term perspectives such as to monitor the influence of the microbiome on S. aureus physiology. It should also pave the way to the identificatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'High-Intensity Coherent Nonlinear Optics'.

assistant: **Innovation**

Optical laser-based technologies are a key technology of the 21st century. Extension of the range of scientific and commercial laser applications requires a constant expansion of the accessible regimes of laser operation. Concepts from nonlinear optics, driven with ultra-fast lasers provide all means to achieve this goal. However, nonlinear optics typically suffer from low efficiencies, e.g. if high-order processes are involved or if the driving laser pulse intensities must be limited below damage thresholds (e.g. in nonlinear microscopy of living cells, or nonlinear spectroscopy of com-bustion processes). Hence, we require methods to enhance nonlinear optical processes. The field of “coherent control” provides techniques to manipulate laser-matter interactions. The idea is to use appropriately designed light-matter interactions to steer quantum systems towards a desired out-come, e.g. to support nonlinear optical processes.The goal of HICONO is to combine the concepts of coherent control with high-intensity nonlinear-optical interactions. The particular aim is to enhance the efficiency of nonlinear optical processes and extend the range of high-intensity laser applications. HICONO will develop new coherent con-trol strategies matched to high-intensity nonlinear optics. This will push high-order frequency con-version towards larger output yield, enable novel applications in high-resolution spectroscopy and microscopy, and drive novel technologies for ultra-short pulse generation and characterization. The close cooperation of HICONO with industry partners will lead to commercially relevant devices.In terms of training, HICONO aims at the development of young researchers with appropriate skills to exploit the concepts of high-intensity laser technologies, laser-based cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multi-partner European test beds for research Networking' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The main goal of IST Project MUPPET is to integrate and validate, in the context of user-driven large-scale test beds, ASON/GMPLS (Automatically Switched Optical Network/Generalised Multi Protocol Label Switching) technology and network solutions as enablers for future upgrades to European research infrastructures. This goal will be pursued by creating a large experimental environment to assess the proposed network solutions, and that will be offered as an open test platform to other European research projects and users.The test bed will represent a multi-layer network based on IP/MPLS and ASON/GMPLS technologies, equipped with a unified control plane and designed to support the highly demanding applications of the European research community. Some of the key project objectives are as follows: to identify service and network requirements of high-end applications for European research environments and the matching ASON/GMPLS network features; to identify solutions for an effective integration of the ASON/GMPLS network layer with the IP/MPLS one, on which the European research networks are and will be based; to solve issues of interoperability between different network domains and of end-to-end provisioning across heterogeneous network environments, in order to enable true pan-European broadband services; to experimentally assess the proposed solutions through lab and field trials in real user environments and with a large user community, including European NRENs.Taking advantage of the strong asset of existing test beds, the MUPPET Project brings together leading European players from NRENs, operators, industry, research institutes and universities to ensure that all the aspects of advanced networking and emerging applications are covered. Different local test beds will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Quantitative risked prediction of carbonate scale in hp/ht/hostile hydrocarbon reservoirs for best practice production management' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Objectives The objective of the project is a quantitative methodology for forecasting changes in water chemistry, particularly precipitation of carbonate scale, in a form usable by industry. This will be achieved in three stages within this project and will aim for a pilot field demonstration in a future THERMIE project via an oil company or SME. Technical approach - To develop a reliable (robust, rapid and accurate), experimentally-verified geochemical computer simulator able to predict thermodynamically and kinetically near-wellbore changes (mineral precipitation and dissolution) occurring in a reservoir at production start and during production. - To determine the relative significance of the controls - pressure, pressure-changes, temperature, rates of change and brine composition - for the geochemical forecasting of carbonate scale during field life production timescales. - To describe the heterogeneity of oilfield formation water compositions sufficiently to be able to predict natural variations as a function of time/production history. - To produce data on the controls of carbonate scale precipitation from laboratory experiments, simulating both well-bore and reservoir, suitable for calibrating/verifying the computer simulations. - To develop a predictive tool (for industrial use) for quantitative assessment of carbonate scale, including the effects of iron, H2S and organic acids. - To produce guidelines for water sampling and disposal, where certain ion concentrates exceed regulatory and/or environmentally acceptable levels. Expected achievements and exploitation The objectives will be achieved in three stages, Stage A: data quality assurance, combining field data (BP), laboratory data (IC, BRGM, RU) and theoretical modelling BRGM, IC) to develop a reliable (robu