RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Synaptic stability and modifiability:protein synthesis and degradation in neurons' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Control of neuronal protein homeostasis (proteostasis) is critical under both normal and abnormal synaptic function. Neuronal synapses possess 100-500 protein species that range in their copy number at individual synapses from 10-100+ copies. In order to maintain synaptic function it is clear that there must be tight regulation of protein synthesis, degradation and trafficking.  In neuronal dendrites, the machinery for both protein synthesis and degradation is present in or close to the synaptic cleft, endowing them with the capacity for local alterations in the proteome. Indeed, it is well-established that some forms of synaptic plasticity require local protein synthesis or protein degradation. The main objective of this project is to clarify the cross-talks between protein synthesis and degradation in neurons, since these two cellular processes have to be coordinated for keeping proteostasis since they have mostly been studied independently. The experimental approach will include manipulating protein synthesis and degradation globally and locally (dendrites) in dissociated neurons and brain slices. I will also study the changes in protein synthesis and degradation in response to different synaptic plasticity paradigms, centered in the hippocampus. These studies will certainly contribute to a better understanding of the molecular mechanism responsible of proteostasis in neurons and its role in normal neuronal function, neuronal plasticity and will have clear implications to understand disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Enhancing and Strengthening the Excellence in Interdisciplinary Biomedical Research at TRANSCEND' to be submitted under Horizon 2020.

assistant: **Abstract**

TRANSCEND, designed as a translational research centre at the Regional Institute of Oncology (IRO), an university hospital, due to the EU Structural Funds, is in a emergent stage of its development. The centre, planned to generate a translational repertoire of biomarkers capable to develop the diagnostic tumor taxonomy and to keep going the personalized therapy, was founded on the interdisciplinary interplay between several cell and molecular high-throughput technologies. It therefore offers a stimulating and dynamic scientific and clinical environment to reach its maximum potential by extending the current scientific aims to a more pronounced inter-, multi- and transdisciplinary approach of the biomedical research. Such a goal will be fulfilled by exploring the huge opportunities brought by nanomedicine in development of less expensive and more powerful devices and functionalized nanocarriers used for the diagnosis and treatment of human diseases. Hence, the ambitious goal of the ESEI-BioMed project is to enhance and strengthen the excellence of the interdisciplinary biomedical research at the TRANSCEND research centre. To meet this objective, a highly successful and experienced leadership (ERA Chair holder) whose experience and professional value, including a range of skills from excellent research manager to excellent researcher in the field of nanomedicine-oriented research, will be hired aiming at implementing positive changes in the actual organization of the centre. The interdisciplinary scientific plan and the management skills of the ERA-Chair holder will certainly be the catalysts of the creation of an interdisciplinary team made of highly-skilled and dedicated researchers capable to properly address the scientific challenges and finally to increase the intern
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A solution for plastic waste pollution', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Since the 1970s, the mismanagement of plastic waste has been increasingly threatening our health and environment. Rather than been reduced, plastic production is growing exponentially. By 2050, the estimation of plastic waste in landfills or in the natural environment verges on 12 billion metric tons, if current production and waste management trends continue. Societies are raising awareness about this concern, although our dependency makes nearly impossible to imagine a world without plastics. This urges for a solution making plastic production and degradation sustainable. To date, important efforts have been made to isolate and identify unique microorganisms capable of utilizing plastics as a carbon source. Although there is empirical evidence of it, the rates of biodegradation are still very low. In SOLFORPLAS project, we will apply cutting-edge biology tools, including fermentation and analytical processes, together with state-of-the-art methods in industrial microbiology research, to investigate plastic biodegradation using a highly-optimized strategy that combines an extruder and a bioreactor. The innovative combined strategy will integrate physical, chemical and biological treatment, which will mimic the whole biodegradation process taking place in worms. Multiple polymer characteristics will be monitored to determine/quantify its biodegradation. Overall, SOLFORPLAS project aim at stablishing a combined strategy to carry out plastic biodegradation as a solution for plastic pollution, one of the biggest environmental that humans are facing in this century.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Chemical biology of autophagy'.

assistant: **Concept**

Autophagy is a cellular pathway that regulates the degradation and recycling of proteins and organelles. This mechanism is initiated with the formation of a phagophore, a cup-shaped double membrane that engulfs the cytoplasmic material to be degraded. The phagophore is then elongated and sealed to generate an autophagosome that will be fused with a lysosome, thereby delivering the cargo for degradation. Several ubiquitin-like proteins have been shown to have a crucial role in regulating autophagosome generation and its fusion with the lysosome. One of these proteins is LC3-I, is a soluble cytosolic protein that associates with the autophagosome after C-terminal conjugation to a phosphatidylethanolamine unit (LC3-II).  This membrane association is reversibly modulated by the cysteine protease atg4, which deconjugates PE from LC3-II, thus recycling the soluble LC3-I. Detailed studies of the molecular mechanism regulating autophagosome formation and the role of LC3-I and LC3-II are unknown, mainly due to the lack of tools enabling a profound characterization of these processes. Herein, we propose the generation of semisynthetic lipidated LC3 proteins using a chemical biology approach. The fully modified proteins should be unvaluable tools that will contribute to the characterization of the factors regulating autophagy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Innovative precast panels for Integrated SEismic and Energy upgrading of existing buildings envelopes' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

There is an urgent socio-economic and environmental need in Europe for sustainable and effective solutions for integrated seismic and energy upgrading of existing buildings as recently adopted by the Green Deal-Renovation policy. Although the field of integrated seismic and energy upgrading has received great attention in the academic community in the last five years, further research is required towards faster, and eco-friendly integrated retrofitting solutions. This project, i-SeePanel, goes several steps beyond the state-of-the-art which still lacks of the real applications of integrated retrofitting solutions, via the development of Innovative externally bonded precast panels, in accordance with Life Cycle Thinking (LCT) principles, for integrated seismic and energy upgrading of existing buildings envelopes.  The proposed precast panels combine the promising seismic strengthening solution TRM (composite material consisting of fibre-textiles reinforcement embedded into an inorganic matrix) with insulation materials providing several advantages compared to cast-in-place solutions by guarantying the effectiveness of the solution (quality-controlled) with high aesthetic and geometry adaptability potentials, and by reducing the time of the intervention, the inconveniences for the inhabitants and the labor effort due to simplifier installation procedure. The research activities of this project include the experimental work for the production and characterization of the matrix material and of the precast panel, pilot laboratory applications on full-scale masonry-infilled RC frames, and the developing design guidelines for proposed applications. The outcomes obtained from this project will encourage the renovation of existing buildings and will aid the authorities in fundin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Asset Prices and Macro Policy when Agents Learn' (APMPAL).

assistant: **Innovation**

A conventional assumption in dynamic models is that agents form their expectations in a very sophisticated manner. In particular, that they have Rational Expectations (RE). We develop some tools to relax this assumption while retaining fully optimal behaviour by agents. We study implications for asset pricing and macro policy.We assume that agents have a consistent set of beliefs that is close, but not equal, to RE. Agents are ""Internally Rational"", that is, they behave rationally given their system of beliefs. Thus, it is conceptually a small deviation from RE. It provides microfoundations for models of adaptive learning, since the learning algorithm is determined by agents’ optimal behaviour. In previous work we have shown that this framework can match stock price and housing price fluctuations, and that policy implications are quite different.In this project we intend to: i) develop further the foundations of internally rational (IR) learning, ii) apply this to explain observed asset price price behavior, such as stock prices, bond prices, inflation, commodity derivatives, and exchange rates, iii) extend the IR framework to the case when agents entertain various models, iv) optimal policy under IR learning and under private information when some hidden shocks are not revealed ex-post. Along the way we will address policy issues such as: effects of creating derivative markets, sovereign spread as a signal of sovereign default risk, tests of fiscal sustainability, fiscal policy when agents learn, monetary policy (more specifically, QE measures and interest rate policy), and the role of credibility in macro policy.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Component and object oriented maturing development process through reuse organization' (COMPRO).

assistant: **Concept**

The evolution from character based user interfaces using MS-DOS to graphical user interface using MS Windows 95/NTand 32 bits architecture causes the complexity of the application to increase significant.- By adopting new processes, methods and technology which gives the opportunity of component based reuse, we target quality improvement, increased productivity and decreased time to market.- The goal is to reach level 2 and parts of level 3 of the Reuse Maturity Model (RMM).The experiment will introduce organised reuse by using a component based object-oriented development process.THE EXPERIMENTNew roles, methods and techniques will be used to create a new software development process which will result in reusable components.The experiment will include the following activities:- New roles will be introduced to dedicate knowledge vertically. Roles will be defined that each covers a special interest responsibility; Client/Server architecture, Repository administration, User interface, OLE business logic and design- Object oriented development will be done using OO-ram.- A component repository will be constructed.- The experiment will be processed in steps of 3 months length, with evaluation after each step.- Metrics based upon GQM will be used to evaluate the process.The experiment foundation are two baseline projects:1. Baseline 1, which is maintenance of a invoice system developed in COBOL with no reuse.2. Baseline 2, which is a new development of the invoice system developed in Borland Delphi with reuse as a main goal.Baseline 1 will be used as scale for the metrics on baseline 2.DI Systemer AS has a total of 20 employees, 7 of these will be involved in baseline 2.EXPECTED IMPACT AND EXPERIENCEDI Systemer AS has the goal to improve their development process by introduc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Bio-based Hydrogels by Click Chemistry for Cartilage Tissue Engineering' under Horizon Europe.

assistant: **Concept**

Cartilage injury afflicts over a million patients annually in Europe and it is a serious problem due to Europe's ageing population. Hydrogels are promising materials for cartilage tissue regeneration in case they are designed accordingly. The use of synthetic materials suffer from biocompatibility and toxicity problems while natural materials can have drawbacks such as low mechanical strength, limited types, insufficient integration with host tissues and easy contamination with bacteria due to high biocompatibility. ClickBioGel aims to fill this gap through fabrication of bio-based hydrogels for cartilage tissue regeneration using a ternary material system composed of collagen, hyaluronic acid and K-carrageenan to advantage from their synergetic effects, and the “Click” chemistry concept, particularly thiol-ene and Diels-Alder reactions, for the selective and high yield chemical crosslinking of the hydrogels under mild reaction conditions. Chitin nanofibrils will be dispersed in the hydrogel precursor for enhancing the mechanical properties as well as antibacterial and bioadhesive characteristics while RGD peptide will be attached on the hydrogels for cell-adhesiveness. The production of the hydrogels will mainly be in three categories as photocrosslinked hydrogels, 3-D printed hydrogels  and light-free injectable hydrogels, which will allow the tunability according to the needs. In vitro cell viability, cytotoxicity and chondrogenesis performance of the hydrogels will be evaluated. With the support of my supervisor (Prof Sangermano), his infrastructure at Department of Applied Science and Technology, as well as the interdepartmental biomedical research centre and the multidisciplinary additive manufacturing research centre at Politecnico di Torino, the fellowship will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Microbially Induced Mineralisation of Wood for Improved Fire Resistance'.

assistant: **Innovation**

Wood is the only renewable construction material and holds great promise for sustainable built environments of the future. However, its combustibility is a major limitation. The drawback of using traditional fire and flame retardants is the toxicity and volatility of some of their components and the loss of chemicals by leaching, leading to poorer performance. Mineralisation of wood offers a green alternative, but current strategies often require a costly technical setup for supercritical gases or the use of harmful chemicals to achieve the deposition of minerals deep inside the wood structure. Biologically induced mineralisation is a widespread phenomenon occurring in all kingdoms of life. In recent years, microbially induced calcium carbonate (CaCO3) precipitation has been proposed as a potential solution to address many environmental and engineering issues related to the enhancement of inorganic materials (protection of concrete, soil consolidation). However, the potential for using fungi has received relatively little attention compared to bacteria. The MICRO-INSERT project will investigate the feasibility of using fungi as CaCO3 carriers to develop a novel bioinspired mineralisation process for biobased building materials. Wood as a highly porous, three-dimensional organic scaffold will be mineralised to create hierarchically structured organic-inorganic hybrid materials with novel properties, including improved fire resistance. The proposed bioinspired treatment incorporates ideas for sustainable materials design, circularity, reduction of toxicity, and lowering the negative impact on the environment. The MICRO-INSERT project will stimulate innovation and knowledge transfer between the host and ER by building a solid research network, organising events, mentoring
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unraveling metabolic settings and targeting metabolic enzymes with selective lethality in BRAF and NRAS mutant melanoma tumors' (METABOSET).

assistant: **Innovation**

Melanoma is the most lethal form of skin cancer. Therapeutic alternatives to metastatic melanoma are very limited. Activation of RAS pathway appears to be the central motor driving melanoma development and maintenance, where BRAFV600E and NRASQ61L are found in ~ 50% and 20% of human melanomas, respectively. Although, these mutually exclusive mutations affect the same pathway emerging preclinical and clinical evidence suggests that NRASQ61L mutant melanomas have patterns of signal transduction and biological behavior that is distinct from BRAFV600E mutant melanomas. These patterns include a differential response to metabolic stress. We believe that successful exploitation of mutations in melanoma will be dependent on understanding not only mutations and their frequency but their genetic and biochemical/metabolic context as well. The overall objective of the present project is to find novel therapeutic alternatives to treat NRASQ61L and/or BRAFV600E mutant melanoma tumours by targeting specific metabolic enzymes, such as Aldehyde Deshydrogenases, with potential synthetic lethality.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Triangulum: The Three Point Project / Demonstrate. Disseminate. Replicate.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The Triangulum project will demonstrate how a systems innovation approach based around the European Commission’s SCC Strategic Implementation Plan can drive dynamic smart city development. We will test the SIP across three lighthouse cities: Manchester, Eindhoven and Stavanger, which represent the main typologies of European cities. They will be complemented by our follower cities Prague, Leipzig and Sabadell. This powerful combination reflects an urban population of between 100k and 1,2m inhabitants across six different countries, allowing us to demonstrate successful replication across a wide range of typical urban areas in Europe. Each city has already made significant progress towards the transition of becoming a smart city; developing their own individual approach reflecting specific local circumstances. These inherent strengths will now serve to accelerate the smart city development across proposed demonstration sites within Triangulum. The suite of projects developed will be based around zero/low energy districts, integrated infrastructures and sustainable urban mobility designed to deliver a range of cross-cutting outcomes across different sectors and stakeholders. This will provide the basis to ‘road test’ the SIP and provide recommendations to the Commission on how it could be improved to facilitate wider replication. The Triangulum goals target a series of direct impacts around; reduced energy consumption of buildings, increased use of renewable energies, increased utilisation of electric vehicles, deployment of intelligent energy management technologies and the deployment of an adaptive and dynamic ICT data hub. The design and implementation of innovative Business Models and the activation of citizens as co-creators are core cross-cutting elements to base th