RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dissecting the role of microtubule motors in the correction of erroneous chromosome-microtubule attachments' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Accurate chromosome distribution during mitosis requires that each pair of sister chromatids attaches to microtubules from opposite spindle poles via centromere-based kinetochores. However, incorrect kinetochore-microtubule attachments can be formed. These errors must be corrected to prevent chromosome missegregation and the resulting aneuploidy, an abnormal chromosome count characteristic of most human cancers. Error correction relies on the centromere/kinetochore-localised kinase Aurora B, which promotes the depolymerisation of kinetochore-binding microtubules in response to lack of tension within erroneous attachments. Tension locally modulates the accessibility of Aurora B to its substrates, which include the microtubule-depolymerising motor MCAK. Paradoxically, Aurora B suppresses MCAK activity and should, therefore, stabilise erroneous tensionless attachments. This contradiction nurtures the ambiguity of the long-sought error correction mechanism. Findings from the host laboratory provide new insights into this process. Microtubule poleward flux, driven by motor-mediated sliding of interpolar microtubules, suppresses MCAK depolymerising activity, potentially by generating tension within attachments. My goal is to provide a precise and integrative mechanism on how motor proteins modulate the error correction mechanism. I will focus on three key objectives: (1) identifying the flux-generating motors that create tension within attachments, (2) determining the role of tension in MCAK-mediated error correction, and (3) dissecting the tension-related interplay between Aurora B and MCAK during error correction. To achieve this, I will integrate super-resolution live cell imaging with acute protein depletion using the auxin-degron system, delivered at endogenous loci thro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Strategic initiatives to develop an interdisciplinary organization that contributes research and provides education on ethical aspects of biotechnology' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

This strategic initiative is launched to correct the insufficient disciplinarian and theoretical characterization of the branch of Ethics concerned with Biotechnology, and the virtual lack of Biota-Ethics teaching, particularly at the level of the doctorate student. Thirteen of the foremost authorities in the field, from eleven different European countries, will meet twice a year to delineate and approach those aspects of the interphone biology-industry where ethical discrimination is required, consult with Witnesses" (ranging from Industry to Research Institutes and to NGOs), organize cooperative studies in ice-breaking areas, and discuss means and methods to translate research into education. Two pilot courses and one conference are planned during the three-year initiative, whose eventual goal is the establishment of a European School of Biota- Ethics."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Exchange bias in two-dimensional van der Waals heterostructures'.

assistant: **Objectives**

Exchange bias has been vital in magnetic storage devices to pin the magnetisation of the ferromagnetic reference layer in a fixed direction. It was extensively studied in thin-film heterostructures, however the origin of exchange bias is not well understood due to the subtle nature of the interfaces. Recent discovery of two-dimensional van der Waals magnetic materials opens up new avenues to scout for origin of exchange bias. Unlike thin-films, atomically sharp interface registry of two-dimensional materials is crucial for this purpose. The primary objective of this project is to do investigations on exchange bias in two-dimensional heterostructures to address the most fundamental at the same time enigmatic question -  'what is the underlying physics that controls exchange bias?!'. For this, the interface domain structure of the ferromagnetic/antiferromagnetic bilayer heterostructure will be investigated employing advanced synchrotron based x-ray photoemission electron microscopy facilities with polarisation control, which is one of the major expertise of the host. Embedded into two work packages, I intend to tackle this problem in two different interface spin configurations by judicious choice of antiferromagnetic layer; (i) parallel coupling of spins with the spins in the antiferromagnetic layer pointing out of the plane and, (ii) perpendicular coupling with the atomic spins of the antiferromagnetic layer lie in the two-dimensional plane.  Electric field control of magnetism has been central to the sustainable advancement of spintronic devices. Two-dimensional materials are extremely sensitive to external electrical stimuli and demonstration of a field effect device based on two-dimensional magnetic materials could be remarkable. Taking advantage of the semiconducting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European network for surveillance and control of tse in small ruminants' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The aims of this Concerted Action are to build a long-term sustainable network for the creation and dissemination of knowledge which will lead to(i) a better understanding and control of SR-TSE; and(ii) an integration of research efforts at the European level.Twenty-nine institutes from nineteen countries, including newly Associated States will participate. There will meetings on specific themes twice yearly at which experts will gather. This is complemented by continuous work packages on specific themes, which will run throughout the Concerted Action, and exchange trips to pursue collaborative work. The information created will strengthen the small-ruminant TSE research infrastructure and facilitate co-ordination of research throughout Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Open Innovation Test Bed for nano-enabled Membranes' (INNOMEM).

assistant: **Concept**

INNOMEM gathers some of the most recognised Membrane departments (>20) in Europe and acknowledged facilitators of technology transfer, corporate finance, funding and coaching, making available (i) the most promising and breakthrough manufacturing pilots and (ii) advanced characterization techniques and modelling together with (iii) non-technical services through this Test Bed: while relevant improvement metrics can be defined, the potential network of reachable stakeholders counts thousands of businesses on an international scale. Key facts are reported below. Within the scope of INNOMEM, main different types of membrane materials (polymeric, ceramic, metallic and nanocomposite), surface modification, membrane morphology and geometry and applications will be covered, providing for the first time a single entry point for industrial partners, mainly SMEs, aspiring to answer their concerns but with minimum investment costs and reduction of risks associated with technology transfer, while opening-up opportunities for demonstration of innovative nanomembranes in real life industrial problems (TRL7) and thus faster opening the market for these new products. The main KPIs for INNOMEM: Technical: 20% Membrane productivity improvement, 30% faster verification, >40% CO2 emissions and energy consumption reduction. Non-Technical: 10 Showcases, >15 Democases, >100 reachable SMEs and > 300 reachable investors.INNOMEM stems from the consideration that the development of products based on advanced membranes and nanomaterials require access to finance and an optimised business planning, relying on a sound prior analysis of the market, of the economic impacts and capacity of a company. The project aims at developing and organizing a sustainable Open Innovation Test Bed (OITB) for nano-en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Novel Gene Therapy Based on the Activation of Endogenous Genes for the Treatment of Ischemia - Concepts of endogenetherapy, release of promoter pausing, promoter-targeted ncRNAs and nuclear RNAi'.

assistant: **Objectives**

Background: Therapeutic angiogenesis with vascular endothelial growth factors (VEGFs) has great potential to become a novel, minimally invasive new treatment for a large number of patients with severe myocardial ischemia. However, this requires development of new technology. Advancing state-of-the-art: We propose a paradigm shift in gene therapy for chronic ischemia by activating endogenous VEGF-A,-B and -C genes and angiogenic transcription programs from the native promoters instead of gene transfer of exogenous cDNA to target tissues. We will develop a new platform technology (endogenetherapy) based on our novel concept of the release of promoter pausing and new promoter-targeted upregulating short hairpinRNAs, tissue-specific superenhancerRNAs activating specific transcription centers involving gene clusters in different chromosomal regions, small circularRNAs formed from self-splicing exons-introns that can be regulated with oligonucleotides and small molecules such as metabolites, nuclear RNAi vectors and specific CRISPR/gRNAmutatedCas9-VP16 technology with an ability to target integration into genomic safe harbor sites. After preclinical studies in mice and in a newly developed chronic cardiac ischemia model in pigs with special emphasis on the analysis of clinically relevant blood flow, metabolic and functional outcomes based on MRI, ultrasound, photoacoustic and PET imaging, the best construct will be taken to a phase I clinical study in patients with severe myocardial ischemia. Since endogenetherapy also involves epigenetic changes, which are reversible and long-lasting, we expect to efficiently activate natural angiogenic programs. Significance: If successful, this approach will begin a new era in gene therapy. Since there is a clear lack of technology capable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Modelling the Influence of Cannabinoids on the Embodied Mind' (CANNABODIES), addressing dissemination and exploitation.

assistant: **Impact**

The world is in the midst of a cannabis craze. After decades of criminalization, cannabinoids such as tetrahydrocannabinol (THC) and cannabidiol (CBD) are suddenly everywhere – in new medicines, in the media, and even in food and cosmetics. But how do cannabinoids influence our brain and body? Much of what we currently know about these compounds comes from neurobiological studies of the endocannabinoid system in animals. Additionally, clinical research suggests that cannabinoids offer promising new treatments for mood and affective disorders, addiction, chronic pain and fatigue, and inflammatory illnesses. However, little is known about how these compounds influence the neural or embodied processes which underlie conscious feelings of emotion, pain, or motivation. This not only limits our ability to design effective cannabinoid-based treatments, but also to negotiate the rising influence of cannabis in our society. To address this gap, in this project I will develop a novel interoceptive self-inference framework which explains how cannabinoids alter the neural mechanisms underlying our embodied and affective selves. To do so, I will use a combination of computational modelling, neuroimaging, subjective measures, and physiological recordings to map the influence of cannabinoids on brain-body interaction in four key psychological domains: interoception, emotion, motivation, and pain. This will enable me to reveal the computational mechanisms by which cannabinoids influence each of these domains. Further, by pooling data across all projects, I will deliver the largest single neuroimaging study of cannabinoid mechanisms to date. This project will answer questions such as: what is the computational basis of cannabinoid effects on brain and behavior? Do THC and CBD exert oppo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Impact Monitor 2' in the context of a Horizon Europe call.

assistant: **Objectives**

Impact Monitor 2 is a project to deliver a coherent and holistic Toolbox and Framework, including their application to preliminary impact assessments of R&I from Horizon Europe projects, Clean Aviation and SESAR 3, that will be the reference choice for the definition and assessment of environmental, climate and competitiveness policy options of European aviation R&I and regulatory measures. Bolstered by its profound knowledge and multidisciplinary expertise, a consortium consisting of 10 research establishments and academic institutes deliver this Toolbox and Framework with preliminary impact assessments, by building on the experience and outcomes of the project from HORIZON-CL5-2022-D5-01-14 of the same consortium and by exploiting the consortium’s close working relationships with EC (e.g. DGs CLIMA, MOVE, ENV and RTD), Clean Aviation, SESAR 3, and EASA. This Toolbox and Framework advance the already established reference Toolbox and Framework developed in that project through enhancing the systematic approach to perform coherent and holistic impact assessments of European aviation R&I and the support to key stakeholders in science-based informed policy decision-making for European aviation R&I with improved analysis capabilities and newly integrated impact models. Assessments are carried out for both SMR and LR vehicles for climate, environment and competitiveness.


**Keywords:** Aviation, R&I, Impact Assessment, Support for Decision-Making
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ECIU University Research Institute for Smart European Regions' (SMART-ER) targeting Horizon 2020.

assistant: **Abstract**

The ECIU University Research Institute for Smart European Regions (SMART-ER) is a research, innovation and education alliance, enabling all member universities to jointly address complex societal challenges under the UN SDG11 (Make cities and human settlements inclusive, safe, resilient and sustainable).SMART-ER, organized as a virtual research institute, designs and implements research, value-captures and delivers solutions to SDG11 challenges, identified by the ECIU University Erasmus+ project. SMART-ER, together with stakeholder groups at a local and international level, showcases and works according to a shared R&I Agenda, focused on social needs, and its implementation plan. SMART-ER will align and bring together research capacities, both scientific and management capacities, bring together researchers and share a common vision, creating a virtual research institute as an example of how to overcome the limits of each single institution.It means, in fact, to implement a new model of doing research and innovation without walls, because:•is a way to leave behind the ivory tower, promoting dialogue with society•it will  overcome the limitations of disciplines, sectors and countries•it will be mainly based on setting a virtual collaborative environmentAll partners will join efforts to develop and test transformative approaches focused on R&I that are so needed:•Mapping relevant information regarding ECIU University resources and infrastructures, practices and actors needed to move to the second phase•Developing the internal plans, procedures, training contents and platforms that will allow the creation and the operability of the SMART-ER•A capacity building programme (Seed Programme and SMART-ER Academy) and citizen science initiatives that will be used as a testbed to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Social cohesion and subjective well-being: An exploration of their dynamic interplay amongst migrants in Vienna and Budapest' (WELLCOH) under Horizon Europe.

assistant: **Objectives**

WELLCOH seeks to explore the relationship between social cohesion (SC) and subjective well-being (SWB) in the case of immigrants in Vienna and Budapest. Its innovative approach is not simply the strong linkage of the two concepts, but rather the attempt to understand their two-way causal relationship within one research framework.The aim of the project is to answer the following questions. How do immigrant communities perceive social cohesion (social exclusion, perceived tensions, intergroup trust etc.) and subjective well-being (life satisfaction, happiness, eudaimonia) in comparison with the native-born population and the European statistics? Has immigrants' well-being improved linearly with their material gains, or has it failed to reach the expected level due to the immaterial factors? What role do social relationships play in this process and how does SWB influence their migration intentions (stay permanently, return to the country of origin, or leave for another country)? How do the group-specific SWB differences influence the strength of social cohesion in Vienna and Budapest, and what are the main differences between the two cities regarding the social cohesion-subjective well-being nexus?The project applies a mixed methods approach, including secondary analyses (literature review, statistical data, international and national surveys: EQLS, EU-SILC, VQLS and the Hungarian microcensus) and the combination of qualitative and quantitative methods: focus groups, interviews and two additional surveys in Vienna and Budapest. The empirical findings will contribute to improving the existing theoretical literature, and they are expected to facilitate more effective, evidence-based policies in both countries. The Challenge of Urban Futures Research Platform at the Univers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Microwave Quantum Photonics for Quantum Technology and Fundamental Physics' (QPHOTON), addressing dissemination and exploitation.

assistant: **Impact**

With the proposed research programme we plan to pioneer a platform that provides experimental access to the statistics of the microwave photons, thus opening up single-photon experiments in solid-state quantum devices.Microwave photons play a major role throughout all solid-state quantum technology architectures, including superconducting qubits as well as charge and spin qubits in semiconductors, where they are used for control, coupling and readout. However, the particle nature of the photons and in particular their statistical properties remain unexplored. The main roadblock here is the lack of suitable microwave photodetectors for performing continuous photon counting at high quantum conversion efficiency.We will create sensors probing the timing between two photons with time resolution better than the time–uncertainty Heisenberg limit of the individual photons. Thereby we will create novel measurement tools applicable throughout the quantum technology field. In particular, the photon counting developed in this research programme will open up the avenue to implement quantum computing based on so-called boson sampling with superconducting circuits, combining two key requirements for practical quantum computing: the programmability of the superconducting circuits and the stronger quantum advantage of quantum processors based on boson sampling.Beyond enabling these new measurement capabilities, on the fundamental side we generate unique experimental insights. The interplay between correlated bosonic and fermionic states — e.g., on how the bosonic particle statistics of the photons map onto the fermionic ones of the electrons — is likely to spur new experimental activities around many-body physics. Furthermore, the detection timing resolution beyond the Heisenberg limit