RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Global South Migration and Comparative Integration: A Study of South American Migrants' (GLAM) targeting Horizon 2020.

assistant: **Abstract**

Are integration patterns of southern migrants and their children in the Global South the same as those of their counterparts in the Global North? What is the impact of migrating to the Global South vs. migrating to the Global North, for migrants and their children? GLAM builds on my research and expertise on migrant integration in the Global North to address these lacunae. The aim of GLAM is to study patterns of socioeconomic integration of South-South migrants and their children, and to provide a comparative perspective with respect to their South-North counterparts and to non-migrants in origin countries. To achieve this goal, I will study international migration waves originating in South America, and carry out my global fellowship (GF) in two of these migration waves’ main destinations: Argentina (Global South) and Spain (Global North). The project—which uses advanced quantitative methods—will consist, first, of a case study of migrant socioeconomic integration in Argentina. And, second, of a multisite study that compares the socioeconomic integration of selected southern migrant groups in Argentina, Spain and Italy, and identifies their socioeconomic gains (and loses) in relation to non-migrants at origin. In Argentina I will be based at IDAES, a renowned social science research centre at the National University of San Martin. I will be trained on South-South migration and comparative approaches, and my work supervised by a leading migration scholar in South America, Prof. Marcela Cerrutti. The entire GF will be supervised by Prof. Javier Polavieja, director of the D-Lab, a leading research centre on inequality and discrimination at the University Carlos III Madrid. At the D-Lab, I will improve my methodological skills and contribute with my acquired Global South m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Scientific Advice for Fisheries Management at Multiple Scales' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

SAFMAMS draws insights from existing research projects and management processes on the most useful forms of scientific advice for marine environmental management and then communicates those insights to scientists and decision makers. The SSA will involv e three basic tasks. First, we will collate information relevant to the forms that scientific advice can and should take from research projects focussed on fisheries management. Second, we will interact with seven sets of stakeholders involved in fisher ies management decision making at various scales to help us sharpen the practical lessons from what we have gathered from the research results. Third, we will carry these lessons from fisheries to the broader marine management community. The deliverables include three reviews of the implications of research results for forms of scientific advice, three best practices articles that will be the product of the interactions with the stakeholder groups, a catalogue of marine environmental management efforts that will be the basis of the network building, three policy briefs aimed at decision makers, one of which is an article on research priorities for improving scientific advice in marine environmental management, and a book on the relationship between t he geographical scale of environmental problems and the forms of scientific advice that are appropriate for addressing them
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Low-Energy Aspects of Gauge Unifications and their Experimental Implications' in the context of a Seventh Framework call.

assistant: **Objectives**

One of the most striking results of the last decade's particle physics is the proof that at least two of the three neutrinos entering the weak charged and neutral current processes are not massless, at odds with their Weyl nature within the Standard Model of particle interactions. Their unprecedented lightness and the peculiar shape of the leptonic mixing pattern reflected by the neutrino oscillation phenomena make the origin of neutrino mass a central question of the present-day high-energy physics. Moreover, the intriguing option that neutrinos can be Majorana particles reveals an entirely new aspect of reality in which some of the sacrosanct laws of nature, such as the perturbative conservation of lepton number, can be conspicuously broken.With the advent of the new generation of cutting-edge experimental instruments like, e.g., the CERN's Large Hadron Collider, high-precision neutrino facilities, super-large-volume detectors and other tools, these fundamental concepts will be subject to an unparalleled scrutiny in the coming years, with extremely high demands on the cohesion of many different scientific disciplines.The proposed project is carefully balanced at the interface of the theoretical and experimental frontiers of the modern particle physics research. It attempts to address some of its most profound issues such as the problem of the Standard Model flavour structure, the origin of parity violation and, especially, the nature of the neutrino masses in their core, from the perspective of Grand unification, one of the best motivated hypotheses about the shape of the new layer of the physical reality at very short distances. Besides a great multidisciplinary scientific potential, a thorough understanding of the interplay among physics at vastly different energy s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'High-throughput sequencing to analyse genome variation and evolution in Map strains' to be submitted under Seventh Framework.

assistant: **Abstract**

The project proposed for the IEF concerns Mycobacterium avium subsp paratuberculosis (Map) which causes Johne’s disease (JD), a chronic gastroenteritis affecting principally ruminants and responsible for significant global economic losses to the livestock and associated industries. Controversially, Map has been associated with Crohn’s disease in humans. The epidemiology of paratuberculosis is poorly understood and there is little information on the virulence of strain types, interspecies transmission or wildlife reservoirs. The project will analyse genome sequences from 100 Map isolates to study genetic diversity and evolution. An understanding of the evolutionary dynamics of Map populations has important implications for the control of JD and genome information can provide insights into virulence, pathogenicity and host preference. The objectives are to assemble and annotate the genome sequence of a Type I Map strain, to identify single nucleotide polymorphisms that can discriminate the different strain types, human and pigmented isolates and to perform phylogenetic analysis. Few whole genome intraspecies comparisons of pathogenic bacteria have been done on this scale and this will be the first of such studies in mycobacteria. The project employs state-of-the-art technologies for genome sequencing and analyses and has a European dimension. The fellow will acquire crucial new bioinformatics skills and transferable skills that complement her current knowledge and experience to progress her chosen career in the field of evolutionary biology and diversification of pathogens. This will give her a competitive advantage for a senior research position and will promote networking of scientists across Europe, thereby contributing to the European Research Area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Identification of genes implied in the excysment process of the hipotrich ciliate oxytricha' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content Under adverse conditions, the ciliate hypotrich Oxytricha forms kinetosome-resorbing cysts, in which the nuclear activity is low. When favorable conditions comes the nuclear activity starts and cell begin, the excystment process. In Oxytricha this process have been well established at the structural level but not at the molecular one. The purpose of this research project will be to acquire molecular information' at the onset and during the course of the excystment process. To do this the genes activated in the' excystment stages will be isolated and sequenced. I will focused in those excystment-activated gene codifying for proteins that either regulate transcription or participate in the acquisition of cell morphology. Training content (objective, benefit and expected impact) The objectives are: (i) to construct a catalogue of Oxytricha genes that are transcriptionally active during the excystment process; (ii) to determine the precise cascade of genes being trancribed from the start tothe end of excystment. This objectives will be achieved using common molecular biology techniques, a library construction and screening, cloning or PCR. The use of those sophisticated techniques will benefit my training, as well as the scientific and discussion atmosphere of a multidisciplinary laboratory such as the host institution. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Objective evaluation of cognitive brain function and dysfunction'.

assistant: **Objectives**

The COBRAIN research project will develop standardized noninvasive tests of human cognitive brain functions in health and in different common neuromental diseases and pathological conditions.   The tests will enable objective neurophysiological evaluation of central auditory processing, sensory memory, and attention, which deteriorate in various forms of neuromental disorder. The COBRAIN project will utilize modern functional brain imaging methods and recent major findings of cognitive electrophysiology and magnetoencephalography (MEG) in order to develop standardized tests of cognitive brain function and dysfunction. These tests will permit objective neurophysiological evaluation of central auditory processing, sensory memory, and attention, which deteriorate in various forms of neuromental disorder. The large-scale clinical application of these tests is made possible by recent advances in cognitive electrophysiology and brain imaging technologies that have recently opened a completely new window to brain functions. In particular, COBRAIN will make use of the mismatch negativity (MMN) and its MEG equivalent MMNm which are manifestations of the brain's automatic response to any suprathreshold change in a repetitive sound. These new non-invasive tests will be adjusted for clinical evaluation and monitoring of patients with different types of major neuromental disorders. They will also be fine-tuned for measuring cognitive brain dysfunction in patients with cerebral lesions and in chronic alcoholics, both major concerns for the European healthcare systems. In addition, COBRAIN will try to develop MMN-based non-invasive methods for determining the malfunctioning hemisphere in temporal-lobe epilepsy. A breakthrough has already been made in using MMN for predicting the recov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dreaming of no more renal dialysis: how self-derived tissue and cells can replace renal function' in the context of a Seventh Framework call.

assistant: **Objectives**

For chronic kidney diseases there is little chance that the vast majority of the world¿s population will have access to renal replacement therapy with dialysis. There is yet no adequate alternative with curative intent than allo-transplantation. This approach is seriously impaired by eventually limited graft survival and by the scarce availability of donors. We propose an innovative strategy that would help to simultaneously overwhelm the reduced access to dialysis, the need for organs for transplantation, the avoidance of patient exposure to immunosuppressants. The overall focus is based on the idea of generating new kidneys by tissue engineering technologies starting from a whole-kidney scaffold with intact three-dimensional geometry and vasculature created by de-cellularization of a kidney harvested from the patient with progressive chronic kidney disease (CKD). Repopulation of the kidney scaffold could be achieved with patient-specific induced pluripotent stem (iPS) cells generated by reprogramming to a pluripotent status of somatic cells. After regeneration, the kidney will be transplanted in the same patient. Thereafter, the same procedures will be repeated with the contralateral native injured kidney, after in vivo assessment of the proper functional performance of the newly generated transplanted organ.This goal will be pursued through the three steps introductory to the development of the best strategy for translating the proposed frontier research to patients with CKD:1.Create an intact whole-kidney scaffold by de-cellularization of a rodent kidney and validate theprocedure with a human kidney.2. Attempt to reconstruct the organ by reseeding the rodent and human whole-kidney scaffoldswith iPS cells generated by reprogramming adult dermal fibroblasts to a pluri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Increase of car occupancy through innovative measures and technical instruments' (ICARO).

assistant: **Innovation**

The overall aim of ICARO is to investigate the measures and instruments that can increase car occupancy. ICARO will focus on transport policy research and will deliver valuable and accessible recommendations and guidelines on how to increase car occupancy at both local and national levels.ICARO will carry out a combination of both research and demonstrations, concentrating on the latter.The objectives of ICARO are:(1) to identify best practices concerning technical instruments and organisational measures to increase private car occupancy;(2) to identify and understand the institutional, legal and cultural framework necessary for increasing car occupancy. There may be considerable differences between countries with respect to the acceptance of measures and instruments;(3) to carry out a number of real life demonstrations on techniques and measures that can increase private car occupancy. These demonstrations will involve a mix of innovative and technical measures. The demonstrations will be carried out in 4 European countries. The demonstrations will concentrate on simple and easy to implement schemes on the one hand and on HOV-lanes as a technical measure on the other hand. In addition there will be studies that will analyse through modelling (changes in) the use of HOV-lanes (Saloniki, Salzburg, Leeds, Madrid);(4) to investigate substitute behaviour that might occur as an undesired effect of schemes for increasing the car occupancy;(5) to set up a methodology for selecting the right measures and instruments;(6) to disseminate the results to all interested parties. %Leeds (UK), Salzburg (AT), Brussels (BE), Graz (AT) %There are links with other EU-projects like MOMENTUM and MOSAIC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Coastal sediment transport assessment using synthetic aperture radar' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

In this project we combine our ability to map the bottom topography of shallow seas from SAR imagery, built up in earlier projects,with morphological models in order to study sediment transport in morphologically very dynamic areas. The projects consists of three parts: firstly,a dedicated field experiment provides detailed measurements of the behaviour of short waves,which are out of equilibrium due to interaction with varying currents. In previous research projects lack of such data was identified as the main obstruction for improving our models to interpret radar backscatter signals.In the second part of the project improved models for wave-current interaction and radar backscatter, resulting from an analysis of the experimental data,are integrated in our existing methods to map bottom topographies. These improved methods are applied to generate dense time series of depth maps of selected, morphologically dynamic sites.In the third part these depth time series are used to adjust sediment transport models.The results are evaluated to determine how this procedure can increase our knowledge of the morphological processes in these dynamic sites, and what its potential is for monitoring and predicting morphological changes local authorities managing coastal zones.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project '“In Vivo Click PET Imaging Agents”: Improving clinical companion diagnostics' (Click-It) under Horizon 2020.

assistant: **Objectives**

Companion diagnostics are crucial for drug development and disease management with regard to patient selection, therapy planning and monitoring. Nanomedicines such as antibodies have been proven to be optimal disease-targeting agents because they generally exhibit superior target uptake and retention. However, to date, nuclear imaging of nanomedicines has been limited to the use of long-lived isotopes to be compatible with the slow pharmacokinetics of these large molecules. Major drawbacks are high radiation doses, precluding routine and repeated companion imaging procedures.The Click-It consortium aims to circumvent this issue by using pretargeting approach, which centers on the administration and target binding of a tagged nanomedicine followed by administration and binding of a small, fast-clearing, short-lived radiolabeled probe to the tag of the nanomedicine. This results in lower absorbed radiation doses and in a boost in target-blood ratios, which in turn leads to a superior imaging contrast. PET scan snapshots at multiple time-points provide long-term imaging information by applying short-lived nuclides. So far, only the fastest click reaction, the tetrazine ligation, has demonstrated potential in clinically relevant conditions. Recently, we have shown in a SPECT imaging study that this click reaction can be applied for non-internalizing nanomedicines in vivo.This project aims at expanding the scope of click-pretargeted imaging to intracellular targets, because a majority of nanomedicines internalize and is thus not accessible with the current approach. Furthermore, we will expand our approach to short-lived, non-metal based, small molecule 18F-PET tracers, since PET offers a higher spatial and temporal resolution enabling quantitative decision making in disease