RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Synapse formation and maturity through planar cell polarity pathway'.

assistant: **Innovation**

SynPCP is a MSCA-IF-EF project in Neuroscience aimed at deciphering spatiotemporal mechanisms controlled by the planar cell polarity (PCP) protein Scribble (Scrib) in spine during specification and morpho-fonctional plasticity that depend on the dynamics of the actin cytoskeleton and trans-synaptic adhesions. Growing evidences suggest that PCP signaling is fundamental for neuronal development mechanisms, including dendrite morphogenesis and synaptogenesis. PCP signaling defects have been linked to a number of human neuropathies such as autism. Because of its subcellular compartment localization and interaction with actin, we hypothesize that Scrib nanoscale organization within the spine could control cytoskeleton and/or adhesion dynamics. To address this, I plan to study the coupling or interplay between Scrib-dependent signaling and the assembly of actin cytoskeleton macromolecular complexes and its connection to cadherin-adhesion molecules using biochemistry, biophysics and 3D super-resolution optical microscopy techniques, in normal and pathological conditions. This project will provide novel conceptual insights into the nanoscale segregation of PCP proteins in spines and how individual PCP proteins control the actin cytoskeleton to build functional synapses. This project will offer a multilevel and interdisciplinary approach to understand the consequences of mutations of PCP signaling at the nanoscale, cellular and physiological levels, on the establishment, maturation and function of the basic functional unit of neuronal integration in the complex circuit of the hippocampus: the dendritic spine. SynPCP will be setup at the Bordeaux Neurocampus which is well known for its contribution to synapse development and brain function. This project offers a scientific and tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Lexicographic Infrastructure' in the context of a Horizon 2020 call.

assistant: **Objectives**

The project proposes to integrate, extend and harmonise national and regional efforts in the field of lexicography, both modern and historical, with the goal of creating a sustainable infrastructure which will (1) enable efficient access to high quality lexical data in the digital age, and (2) bridge the gap between more advanced and lesser-resourced scholarly communities working on lexicographic resources. The need for such an infrastructure has clearly emerged out of the lexicographic community within the European Network of e-Lexicography COST Action which will end in 2017.Current lexicographic resources, both modern and historical, have different levels of structuring and are not equally suitable for application in other fields, e.g. Natural Language Processing. The project will develop strategies, tools and standards for extracting, structuring and linking lexicographic resources to unlock their full potential for Linked Open Data and the Semantic Web, as well as in the context of digital humanities.The project will help researchers create, access, share, link, analyse, and interpret heterogeneous lexicographic data across national borders, paving the way for ambitious, transnational, data-driven advancements in the field, while significantly reducing a duplication of effort across disciplinary boundaries.ELEXIS will be carried out by a balanced consortium with distributed geographical origins. It is composed of content-holding institutions and researchers with complementary backgrounds - lexicography, digital humanities, language technology and standardisation -  a crucial feature required to address the multi-disciplinary objectives of the project. In cooperation with CLARIN and DARIAH, it will focus on defining and providing common interoperability standards, wo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Further development of a two dimensional shallow layer model for dense gas dispersion in obstructed irregular terrain including two phase jets'.

assistant: **Objectives**

A TWO DIMENSIONAL SHALLOW LAER MODEL (DISPLAY-2) HAS BEEN DEVELOPED TO BE APPLIED FOR THE PREDICTION OF DENSE GAS DISPERSION IN OBSTRUCTED IRREGULAR TERRAIN. THE MODEL HAS BEEN VALIDATED SUCCESSFULLY AGAINST THE THORNEY ISLAND 8 AND 21 FELD EXPERIMENTS INVOLVING INSTANTANEOUS DENSE GAS RELEASES AT AMBIENT TEMPERATURE ON FLAT TERRAIN WITH (21) AND WITHTHOUT (8) OBSTACLE. IT IS PROPOSED TO EXTEND THE MODEL TO INCLUDE TWO PHASE FLOW JETS. MODEL VALIDATIONS WILL BE PERFORMED AGAINST THE DESERT TORTOISE AMMONIA EXPERIMENT, THE EEC FLADIS T016 AMMONIA EXPERIMENT AND THE EEC-55 PROPANE EXPERIMENT, INVOLVING TWO PHASE JETS WITH AND WITHOUT OBSTACLES. THE MODEL WILL BE VALIDATED IN NON FLAT TERRAIN AGAINST THE EEC HAMBURG WIND TUNNEL EXPERIMENTS INVOLVING CONTINUOUS AND INSTANTANEOUS RELEASES WITH OBSTACLES STREET CANYONS AND SLOPES.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Using CRISPR genome screens and dual transcriptome analyses to dissect host-pathogen interactions in tuberculosis' (Host-TB).

assistant: **Concept**

With more than 10 million cases annually, tuberculosis (TB) remains a global health problem. TB epidemic is exacerbated by the spread of multidrug-resistant TB. Host-directed therapies (HDTs) can improve immune mechanisms by augmenting the ability of host cells to kill M. tuberculosis (Mtb) or by modulating the immune response to prevent excessive inflammation, cell death and tissue damage. Progress with HDT development has been slowed down by the limited understanding of host-pathogen interactions during Mtb infection. Screens of the whole human genome can identify novel genes involved in the immune responses to Mtb infection and susceptibility to TB. Previously, we successfully used genome-wide association studies to identify human genes associated with susceptibility to TB. Here, we will for the first time use the groundbreaking CRISPR technology to screen the human genome in macrophages infected with Mtb and discover genes that are critically involved in host-pathogen interactions. Then, we will comprehensively characterise pathways that mediate impacts of these genes on both the human macrophage and the intracellular Mtb bacilli using dual transcriptome analyses and high-throughput microscopy assays. This novel approach will dissect crucial mechanisms of host-pathogen interaction during Mtb infection and will point to new targets for HDTs of TB.


**Keywords:** Tuberculosis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Joint PhD Laboratory for New Materials and Inventive Water Treatment Technologies.  Harnessing resources effectively through innovation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Future challenges, including climate change and the resulting unpredictability of precipitation patterns and temporal or permanent water scarcity, generate a high diversity of demands on water treatment technologies obliging them to be able to cater towards a variety of source and target water qualities across multiple scales, depending on application. It is evident that this will generate a market pull towards the development of new water treatment technologies, employing new materials or improving the integration of existing technologies. However, the integration of research and innovation within the water sector needs to be supported by education of a new generation of interdisciplinary trained wastewater professionals able to face future challenges and implement wastewater-related directives in practice. The primary objective of NOWELTIES is to organize a platform (European Joint Doctorate) that will provide cutting edge training opportunities for the education of tomorrow`s water treatment experts. The core activity is the research programme (composed of 14 individual research projects) aimed at development of inventive water treatment technologies (advanced biological treatments, inovative oxidation processes, hybrid systems) that allow catering for the varied treatment demands for a plethora of interconnected streams arising from recycling loops. These technologies will be able to control contamination by organic micropollutants (OMPs) and improve recovery of water across a diversity of scales enabling a smart combination of decentralized and centralised approaches. Besides a holistic training in the field of wastewater treatment dealing with state-of-the-art technologies, experimental techniques and knowledge management methodologies, NOWELTIES  will provide a u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Collaborative and network distributed learning environment' (ESERNET).

assistant: **Concept**

ESERNET increases the competitiveness of European industry in using the rapidly developing software engineering methods. The main objective is to establish a world-leading network of excellence in experimental software engineering (ESE). The object of experimentation is in component-based software engineering. ESERNET will perform co-ordinated and repeatable experiments across a wide variety of applications and cultural environments. The results will be packaged and made available through web-based repositories, web-pages, conferences, and other dissemination actions. ESE research requires the co-operation of industry and academia. ESERNET includes an open consortium with a unique combination of 29 members and additional associated organisations from industry, academia, and research with a complementary expertise covering all the required technical competencies.OBJECTIVESTo establish a world-leading network of excellence in Experimental Software Engineering (ESE), the object of experimentation is in Component-based Software Engineering. The results are used for continuous product and process improvement as a means to improve industrial competitiveness and innovation potential.1) Establish an infrastructure for a collaboration network.2) Experimental evaluation and packaging of software engineering methods3) Use ESE methods to facilitate systematic introduction of new methods4) Create synergy from a variety of projects and organisations5) To disseminate and exploit all the results6) Accelerate community-wide learning in software engineering.7) Collaboration and knowledge exchange within and between industry and researchDESCRIPTION OF WORKESERNET reuses results from various European (ESPINODEs, VASIE) and global networks (ISERN), from past projects (PROFES, PERFECT, REBOO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Origins and spread of agriculture in the south-western Mediterranean region' (AGRIWESTMED).

assistant: **Concept**

This project focuses on one of the most fascinating events of the long history of the human species: the origins and spread of agriculture. Research over the past 40 years has provided an invaluable dataset on crop domestication and the spread of agriculture into Europe. However, despite the enormous advances in research there are important areas that remain almost unexplored, some of immense interest. This is the case of the western Mediterranean region from where our knowledge is still limited (Iberian Peninsula) or almost inexistent (northern Morocco). The last few years have witnessed a considerable increase in archaeobotany and the effort of a group of Spanish researchers working together in different aspects of agriculture has started to produce the first results. My proposal will approach the study of the arrival of agriculture to the western Mediterranean by exploring different interrelated research areas. The project involves theapplication of different techniques (analysis of charred plant remains, pollen and non-pollen microfossils, phytoliths, micro-wear analyses, isotopes, soil micromorphology, genetics, and ethnoarchaeology) which will help to define the emergence and spread of agriculture in the area, its likely place of origin, its main technological attributes as well as the range crop husbandry practices carried out. The interaction between the different approaches and the methodologies involved will allow achieving a greater understanding of the type of agriculture that characterized the first farming communities in the most south-western part of Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Alternative splicing and SR proteins in ABA-mediated plant stress responses' (AS-ABA).

assistant: **Innovation**

Abscisic acid (ABA), the major plant stress hormone, plays a crucial role in the response to the most pervasive causes of loss of crop productivity worldwide, including drought and high salinity. Serine/arginine-rich (SR) proteins are RNA-binding proteins that play crucial roles in the regulation of alternative splicing (AS), a key posttranscriptional mechanism for expanding proteome diversity and a flexible means of regulating gene expression in higher eukaryotes. While its functional relevance in plants remains largely unknown, mounting evidence suggests a central role for AS in the response to abiotic stress, in particular by targeting the ABA hormonal pathway. Using gene expression analyses, subcellular localization studies and reverse genetics approaches, this project will investigate the functional significance of six ABA-regulated Arabidopsis SR genes in stress responses mediated by the ABA phytohormone. To gain mechanistic insight into the mode of action of the SR proteins implicated in the ABA pathway, the physiological transcripts targeted by these splicing factors to achieve plant stress tolerance will be identified using a combination of genome-wide and biochemical approaches. In brief, next-generation sequencing technologies will be applied to whole transcriptome analysis (RNA-seq) of plants with altered levels of an SR protein and to RNA immunoprecipitation (RIP-seq) in plants expressing a tagged version of the SR protein. In discovering new plant genes that determine the ability to cope with unfavorable environmental conditions and by revealing the molecular mechanisms underlying their mode of action, this work will pave the way for the development of new efficient strategies to improve crop productivity in specific world regions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Green Computing Node for European micro-servers'.

assistant: **Innovation**

Data-centres form the central brains and store for the Information Society  and are a key resource for innovation and leadership. The key challenge has recently moved from just delivering the required performance, to include consuming reduced energy and lowering cost of ownership. Together, these create an inflection point that provides a big opportunity for Europe, which holds a leading position in energy efficient computing  and market prominent positions in embedded systems.EUROSERVER is an ambitious and holistic project aimed  to arm Europe with leading  technology for conquering the new markets of cloud computing:1. Capitalise on the European strength in embedded and low power computing  to provide an innovative combined architecture-and-technology integration platform that enables the reuse of highly-integrated,high-performance, energy-efficient component subsystems in a micro-server solution suitable across both cloud data-centres and embedded application workload.2. Perform  a combined architecture-technology exploration that creates the hardware and the software for micro-server based computing  in support of cloud-based and embedded applications.3. Evidence this architecture in a data-centre grade low-power physical  micro-server prototype solution utilizing advanced ARM IP, industry leading  FD-SOI fabrication  technology, and state of the art 2.5D device  integration technologies and prove the advantages of these European technologies as the enabler of next generation,low-cost, power-efficient, high-density compute.The EUROSERVER consortium brings together world-class leaders in their own fields and creates the critical-mass required to deliver More than Moore" solutions. A unique differentiator of EUROSERVER is its broad  access to the required industrial t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'New microfluidic tools for characterization of protein-lipid interactions' (MicroProtLip) targeting Horizon 2020.

assistant: **Abstract**

Cellular function and malfunction depends crucially on the interactions of proteins and other cellular components, specifically with lipid membranes. Such interactions are a key to the compartmentalization of a wide range of cellular mechanisms into discrete organelles, allowing to maintain homeostasis. In spite of implications to life sciences and drug discovery our current understanding of protein–lipid interactions is limited. This is primarily due to the challenges imposed by existing methods for determining the fundamental interactions of a wide range of proteins and lipid bilayers due to the high level of heterogeneity of the formed complexes. Recent advances in the development of microfluidic techniques for characterisation of biomolecular complexes together with sensitive optical detection methods open new possibilities for fundamental studies of protein–lipid interactions. The main objective of the proposed project is the development of a transformative microfluidic platforms dedicated for the study of interactions of lipid membranes with protein molecules. Experienced Researcher aims at the implementation of microfluidic technologies: micro free flow electrophoresis and nano deterministic lateral displacement, for the parallel development of two types of platforms. The development of the platform will be highlighted by addressing exemplary fundamental questions in molecular biology of interest that concern a wide range of aspects of mechanism of protein–lipid interaction. The realization of the objectives will be based on close collaboration between academic and non-academic sectors, in pursue to bridge the gap between fundamental and applied research. This action will set up a tight collaboration between the University of Cambridge (UCAM) and Fluidic Analytic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Tribology of Elastomers on Lubricated Surfaces' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The TELLUR project is based on a strong and balanced public-private European partnership including one large multi-national company (Goodyear, Luxembourg) and one university (Aalto, Finland). The project aims at developing new knowledge and technologies in the field of friction between elastomers and lubricated surfaces. This will be done through the understanding of the contact conditions between the tire and the road, and the characterization of the structure and evolution of both contact surfaces. TELLUR aims to:- Understand the links between vehicle wet braking performance and the self-affine roughness properties of lubricated road surfaces,- Establish a strong knowledge base concerning the influence of the rubber compound properties on the rubber– Ice/snow friction mechanism and its evolution,- Implement a method for producing surface samples that resemble worn asphalt to perform tests on rubber-asphalt friction,- Develop intuitive and powerful software to analyze high-speed infrared images acquired during friction tests.Goodyear, as the coordinator of the project, will work in close collaboration with Aalto to ensure that TELLUR produces innovative technological solutions for the automotive industry, that can be further transfer to other areas as well.