RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of non coding RNA in human health and disease' (2007-2013).

assistant: **Concept**

RNA molecules have been already proven to be a key target for disease therapy as well as a tool for the development of new drugs. Since the discovery of small non coding RNA (ncRNA) and all the associated phenomena like RNA interference, the possibility of using RNA-based drugs has become a subject of great interest in the pharmaceutical and clinical fields. ncRNA is at the core of many cellular processes and might become an outstanding landmark in the way how we will fight disease in the future.The objective of this exchange programme is to establish collaborative training and joint research initiatives addressing the role of non-coding RNAs in health and disease.The specific scientific aims are:-To unravel the role of non-coding RNA and RNA-binding proteins in thyroid development, physiology and pathology.-To determine whether thyroid hormones affect non-coding RNAs in osteoblasts derived from adipose stem cells.-To determine whether circulating micro RNAs can be used as biomarkers for heart disease.The programme that we propose to implement will significantly expand biomedical research and training across the Brazilian academic community, while providing the European partner institutions expanded opportunities for collaborations in research and post-graduate education.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Continuous measurements of plankton and environmental variables: towards assessment of phytoplankton community response to environmental change' (CONPLANK).

assistant: **Concept**

Phytoplankton dynamics are highly variable in coastal ecosystems because physical, chemical and biological influences are forced in complex ways. Many important processes that influence coastal phytoplankton dynamics are episodic (e.g. hurricanes, storms and seiches). However, phytoplankton variability at short-term scales is poorly understood. Despite that alteration of the magnitude and frequency of episodic events (storms, rains, droughts) is considered one of the consequences of future global climate change, the potential effects of such changes in coastal ecosystems have not been fully studied. This is due to the difficulty of studying episodic events characterized by unpredictable timing, and the inability of traditional sampling strategies to resolve the scales involved, particularly biological data. The capacity to obtain biological measurements at sufficient temporal and spatial resolution is now possible with new emerging technologies that allow autonomous data of phytoplankton at the species and group levels. The Imaging Flow-Cytobot is a submersible particle analyzer and imager that combines aspects of microscopy and flow cytometry capable of unattended long-term deployments. It produces high-quality images that allow phytoplankton cells to be identified thereby providing taxonomically resolved estimates of phytoplankton abundance with fine temporal resolution. This project will explore phytoplankton biodiversity, variability and their relation to environmental factors at relevant ecosystem timescales. Continuous planktonic and oceanographic high-frequency time series obtained with high technology sensors will be combined with a detailed statistical analysis of the measured time series and molecular analysis of phytoplankton biodiversity. Further research as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Global Industrial Research & Innovation Analyses 2020-21' in the context of a Horizon 2020 call.

assistant: **Objectives**

The main expected impact of this proposal is the better understanding of corporate Research & Development (R&D) efforts in relation to the green deal and sustainability objectives, starting from the top R&D investors in their global competitiveness perspective. For this, the EU Industrial R&D Investment Scoreboards will be developed towards a more meaningful tool regarding the directionality of corporate Research & Innovation (R&I), and systematically include additional indicators, triggering change of its use and change in industry, becoming complementary to the sustainable finance taxonomy. A key aspect here is that, under leadership of JRC.B3, the project will exploit JRC-internal synergies (within Directorates B and C) for covering the global R&I competitiveness picture and adding relevant and more specific information regarding energy and transport as key sectors for the new priorities. Policy impact will also benefit from enhanced co-creation between the project partners.


**Keywords:** Green Deal, industry, competitiveness, innovation, business intelligence, research, innovation, R&I, R&D, R&D&I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Optimal Particle identification Of Single Site events with Underground MKIDs detectors'.

assistant: **Innovation**

The observation of neutrinoless double-beta decay (0) would revolutionise our understanding of neutrinos by affirming their Majorana nature and shedding light on their absolute mass scale and hierarchy. Detecting its monochromatic peak at MeV levels, with half-lives over 1026 years, is a significant challenge. Scientists are striving to push the scale of experimental exposures to tons of material per years. It is only in a background-free experiment that sensitivity scales linearly with exposure, maximising the benefits of increased detector mass. The forefront of this search lies with ton-scale arrays of bolometers at mK temperatures, such as CUORE, which investigates 0 in 130Te using TeO2 crystals, known for their exceptional energy resolution but plagued by background event identification challenges. With its 34% isotopic abundance 130Te emerges as the leading 0 candidate, bypassing the need for the now-challenged enrichment process. OPOSSUM will revolutionise event detection by outfitting 12 CUORE-crystals with six quantum limited  sensors (Microwave Kinetic Inductance Detectors) and a thermistor. This innovative approach will enable discrimination of events by classifying them as Single Site or Multi Site Events. Through pulse-shape analysis, OPOSSUM is set to tag 0 signals with 3 distinction from any background. This method has the potential to lower CUORE's background from 10-2 to below 10-4 counts/keV/kg/year. The success of OPOSSUM will  facilitate rapid deployment within the existing setup without extensive R&D or major financial outlay. OPOSSUM-1ton is poised to become the first bolometric ton-scale, background-free experiment that can aim at surpassing the inverted hierarchy scenario, i.e. <10 meV Majorana mass.My vast experimental knowledge in low-temperatu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Enzymatic engineering of modified Glycostructures'.

assistant: **Concept**

Oligosaccharides are a diverse class of carbohydrates widely distributed in Nature. Their biological significances range from roles as structural elements and energy sources to being ubiquitous constituents on mammalian, bacterial and viral cell surfaces, where they are involved in cell recognition events.Both the selective modification of cell surface glycan structures and the production of competitive glycan ligands are important research areas with potential for developing novel therapeutics. The chemic al synthesis of oligosaccharides is a multi-step endeavour and is particularly difficult in analog synthesis, where additional steps are required to introduce modifications.Increasingly chemists are employing enzymes to take advantage of their rate acceleration, stereoselectivity, regiospecificity and environmentally friendly green chemistry conditions. Our biocatalytic GlycoEngineering approach uses glycosyltransferases that catalyse the transfer of a monosaccharide from a nucleotide donor to an acceptor.We have identified the blood group A and B synthesizing enzymes (GTA and GTB) as models for studying retaining glycosyltransferases. GTA and GTB will be employed for the synthesis of modified blood group glycostructures, using both enzyme engineering and substrate engineering.Based on X-ray and NMR studies of ligand binding to GTA and GTB, different UDP-N-acetylgalactosamine and UDP-galactose donor analogs will be designed with docking and molecular modelling. To overcome potential limitations of native G TA and GTB in analog preparation, their substrate specificities will be broadened by mutagenesis based on sequence, structure and modelling studies.Donor substrate analogs will be chemi-enzymatically prepared and used with native and mutated GTA and GTB t o synthesi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Vitamin D And LIfestyle Intervention for Gestational Diabetes Mellitus (GDM) Prevention' (GDM).

assistant: **Innovation**

Europe is facing a rapidly growing threat from Type 2 diabetes mellitus (T2D), which is undoubtedly associated with an unhealthy diet and a more sedentary lifestyle. Evidence is accumulating that gestational diabetes mellitus (GDM) may be playing a role in this process. Thus it provides a significant opportunity for preventing future T2D. Not only is GDM prevalence on the rise, but intrauterine exposure to hyperglycaemia predisposes the offspring to diabetes and obesity. Another putative contributing factor is a low vitamin D status, which is also increasing in prevalence and may have causal links with both obesity and decreased glucose tolerance. The main aims of this project are: 1) to establish the current status of the prevalence of GDM in Europe and facilitate the adoption of a single diagnostic approach and 2) to deliver the best strategy that prevents GDM. The latter was deemed as not fully feasible within the scope of this call and our decision was to test the most relevant approaches (diet, exercise, vitamin D, alone or in combination) against surrogate variables of GDM (fasting blood glucose, insulin sensitivity, pregnancy weight gain) to come up with the best intervention for entry into a definitive GDM prevention trial. Deliverables include the sample size and modus operandi for such a trial. Value will be added to the project by 1) Assessing variables modifying the uptake of preventive interventions, 2) Exploring health costs of GDM and potential savings of preventive approaches, 3) Improving pathophysiological understanding by assessing intervention effect on several parameters in mother and foetus and 4) Facilitating future research through a well defined cohort of mother-offspring pairs and comprehensive biobanking.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'An ultra-wideband-based location system that allows highly accurate positioning in indoor environments.' in the context of a Horizon 2020 call.

assistant: **Objectives**

Nowadays more than 80-90% of people’s time is spent indoors. Most of this time is spent at the work place, where, the position of a user or a device in a given space is one of the most important elements of contextual information. Location detection, such as the GPS technology, has made a tremendous impact on our everyday lives. Nevertheless, in indoor environments, the usability of the GPS is limited. Radio Frequency Signals (RF) like Wi-Fi, RFID and Bluetooth, light-based technologies like infrared light, sound technologies, and magnetic fields- are all systems commonly used for indoor positioning. However, with an accuracy ranging from 1 to 5m, these technologies are simply not accurate enough for tomorrow’s Industrial Internet of Things. Pozyx Real Time Locating System (RTLS) is GPS for indoors environments. Thanks to our proprietary algorithm that leverages in Ultra-Wideband technology for unparalleled accurate positioning, it is the first IPS to reach up to 10cm accuracy. We is starting a new era of accurate positioning: Pozyx RTLS is as accurate as the most reliable systems in the market like Camera systems and LIDAR with prices that can easily compete with the most affordable systems like Wi-Fi or Bluetooth. So far €747K have been invested into the development of the Pozyx RTLS to ensure and continuously improve its robustness and efficiency. We still need a further investment of €1.8M which will also allow us to finalise engineering and set up a solid EU value chain able to meet the large demand expected during the first years of commercialisation. This will eventually ease our access to new markets, like the entertainment industry. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A Networked and IT-enabled Firm's Perspective on Crisis Management' under Seventh Framework.

assistant: **Concept**

By the middle of the year, experts announced 2011 to be the most expensive year in counts of global disaster damages ever. The EU has articulated its ambition to become an effective player in crisis management as part of the European Security Strategy (Stockholm Programme 2010-2014, Lisbon Treaty). The Hyogo Framework stipulates that a substantial reduction of disaster losses is only possible through advanced governance and management.NITIMesr has been designed as a practice-inspired research initiative that addresses• research and conceptualization of new modes and competencies for coordination and collaboration in heterogeneous actor networks including involvement of individuals,• advanced practices of vertically integrating governance of crisis management, strategic and operative management, with a special focus on• involvement and engagement of self-motivated individuals - actors, agents, volunteer, citizens or, as we call them - entrepreneurs.NITIMesr brings together an interdisciplinary group of researchers and industry partners including the two leading European security clusters around the international court of justice in Den Haag and the Bavarian Security Cluster around the International Campus Aerospace and Security, BICAS, at the German EADS headquarters in Munich. The aim is to explore new frontiers of safety and security with the institutional, governance, organizational and managerial challenges of crisis networks, to develop and test innovative approaches for coordination in real world settings and to build Europe-wide connected clusters for crisis management and implement integrated solutions. Both clusters expect universities to provide the key success factor “talent” through leadership for joint research, education, development and career development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'What is the role of the axonal connections between the hemispheres in sensory processing?', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Why does our brain have two hemispheres and what is the role of connections between them? While it is well known that in humans, each hemisphere has functional specializations, we have little mechanistic understanding of how circuits communicate across the corpus callosum that connects the hemispheres. Moreover, the role of these callosal axons, and the information they convey is highly debated. There are two main hypotheses: One suggests that callosal axons have mainly an inhibitory action in the other hemisphere, while the other suggests that the effect is excitatory. Importantly, this century-old debate among cognitive psychologists and neuroscientists remains to be tested. Here I hypothesize that these views are most likely too simplified. Instead, I propose that the actions of these axons are rather complex, causing sequences of excitation and inhibition. Moreover, I propose that it may be more relevant to study what information is conveyed by the callosal axons. To test this, I will use two-photon microscopy and calcium indicators to study the effects of callosal input on the somatosensory cortex of mice that are trained to perform a tactile discrimination task. The combination of state-of-the-art microscopy, novel viral methods and mouse behavior makes this project very timely. I will monitor the activity of thousands of neurons in a specialized part of the rodent somatosensory cortex, called the barrel cortex, while head-fixed mice perform a whisker-dependent object localization task under the microscope. This high spatial resolution technique also allows monitoring directly the activity of callosal axons. Finally, I will use optogenetics to inhibit callosal input specifically and measure how this influences cortical circuits and behavior. My findings will provi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Using Artificial Intelligence to Support Regulators & Policymakers'.

assistant: **Concept**

AI-innovation in Europe lags behind the US and China. To catch up and ensure pro-European outcomes, AI-regulation constitutes the EU’s main channel to shape the future of AI-development globally. This project will support European regulators and policy makers with knowledge and tools to adequately address challenges and opportunities of trustworthy and ethical AI and to develop and enforce effective regulation of AI based on human rights, European values, and citizens' needs.AI4POL will explore how regulators can use data science and AI-driven tools to improve monitoring and enforcement of regulations such as the Data Act, the Digital Markets Act, the AI Act and in consumer law. To this end, we will focus on a key innovation area, financial services, and how to increase AI-enhanced understanding and citizen feedback for the informed regulation of digital services by developing a large language model for legal jargon translation and a browser-plugin for user feedback about their understanding of laws. We will also analyze how to create and regulate trustworthy AI for financial services, for example with robo-advisors or credit scoring. Taking a long-term, geopolitical perspective, we will develop an early-warning system regarding high-risk AI in autocratic states, including the development of an AI Threat Index and dashboard and piloted with the cases of China and Russia.AI4POL pursues these objectives with a multidisciplinary, diverse research team, combining substantive expertise in AI/data science, ethics, law, economics, and political science with project management resilience, quality assurance and timeline monitoring, and risk-based intervention plans. The consortium has extensive experience in advising policy makers and has reliable contacts to various stakeholder