RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Analysis of the role for coronin 1-dependent cell density signalling in T-cell homeostasis' (COR1-TCELL), addressing dissemination and exploitation.

assistant: **Impact**

Harnessing T-cell homeostasis is important for cancer immunotherapy as well as anti-microbial immunity and the prevention of autoimmune disorders. T-cell homeostasis in peripheral lymphoid organs is known to be regulated through interleukin-7-mediated cytokine signalling and via T-cell receptors recognising self-peptides loaded on major histocompatibility complex. However, recent results suggest a requirement of a third pathway at low T-cell density such as in newborns that depends on the WD repeat protein family member coronin 1, the mechanism of which is unknown. The objective of this proposal is to elucidate the molecular mechanism of coronin 1-dependent sensing of low cell density that contributes to peripheral T-cell homeostasis.In preliminary work, I established a co-culture assay of T cells and antigen presenting cells that recapitulates coronin 1-dependent T-cell survival at low cell density. In addition, I found that adoptive transfer experiments reconstituted the coronin 1-dependent peripheral T-cell expansion in a lymphopenic environment in vivo. To delineate the molecular mechanisms underlying this cell density-dependent signalling mediated by coronin 1, I will combine the originally established in vitro and in vivo assay systems with state-of-the-art single-cell RNA sequencing, in addition to biochemical analysis utilising mass spectrometry. This will identify the signalling pathways and the molecules involved in this density-sensing mechanism. Finally, ad-hoc ablation of coronin 1 using a newly established inducible knockout mouse will reveal the role for coronin 1 in the maintenance of peripheral T cells after successful expansion at post-neonatal stage.The results from this project will define a hitherto uncharacterized density-sensing pathway required f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Free Radical Pharmacology: Generators, Targets and Therapeutic Implications' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Personalised Medicine is the next revolution in medicine. It is anticipated that we will see a dramatic shift towards predictive diagnostics and mechanism-based, individualised therapies. Cardiovascular diseases (CVD) are the leading causes of death and disability and in Europe cause over 4.3 million deaths (48%) per annum. Since the mechanisms of CVD are not understood, the majority of current therapeutic approaches are symptom-orientated and imprecise. Therefore, we need innovative strategies to develop mechanism-based drugs, i.e. drugs, which target the cause of disease. A prerequisite for this is a detailed knowledge on the causes of CVD. One such highly promising mechanism of CVD is oxidative stress, i.e. the increased occurrence of oxygen radicals, an area of utmost medical significance but where so far all clinical trials using antioxidant treatment have failed. Here three major aims are proposed: to identify targetable sources of radical signals that are relevant for CVD, to establish strategies for reversing the molecular damage caused by oxidative stress, and to develop new markers for diagnosis of CVD in humans and mechanism-based treatments. Thereby, a conceptual shift in treating oxidative stress will be achieved. In the long-term, this research will provide measurable outcomes in improved health, new products, and economic benefits by lowering the public health burden and facilitate the growth of biotechnology and pharmaceutical industries in Europe. This will result in a net decrease of health burden and will ensure sustainability of the healthcare system. This fellowship will also help to further attract leading international researchers to Europe to support the internationalisation of the European health and medical research, and to enhance EU’s reputat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Brain injury and trauma monitoring using advanced photonics'.

assistant: **Concept**

Our vision is to develop a suite of standardised non-invasive devices that will provide essential information about brain health in neurocritical care and neuromonitoring, with a particular emphasis on 1. traumatic brain injury: the “silent epidemic of the third millennium” and 2. hypoxia in newborn children. Survivors present permanent neurological conditions that have a profound impact on the quality of life of individuals and their families, and hence a large socio-economic impact. The key factors influencing these conditions and their treatment are the avoidance of brain hypoxia and metabolic disturbances and this is driving the transfer of new neuromonitoring systems to the bedside where they are being shown to have a transformative effect on patient care.BitMap will develop non-invasive photonics-based monitoring techniques and data analysis methods to provide biomarkers that could guide patient management. A cohort of multi-disciplinary Early Stage Researchers (ESRs), embedded in leading laboratories across Europe, will work together on an programme designed to address the key technological and clinical challenges in neurocritical care. The ESRs will benefit from the diverse range of expertise in advanced photonics and clinical application which will substantially enhance their research competitiveness and employability, and will together form a critical mass of skilled people working together towards new technologies for improved neuroclinical care.The challenges involved are fundamentally multi-disciplinary and therefore ESRs trained in a multi-disciplinary environment are essential if progress and clinical impact is to be made. There is currently no graduate programme producing researchers with these attributes, but there is a significant market for such PhDs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pathogenesis and transmission of influenza virus in pigs' (FLUPIG) under Seventh Framework.

assistant: **Objectives**

FLUPIG aims at a better understanding of the role of pigs in influenza pandemics. Pandemic influenza viruses come from wild birds, but they must adapt to efficient replication and transmission in humans to cause a pandemic. Pigs are considered important intermediate hosts in which avian viruses adapt to mammals before they transmit to humans. However, the exact role of pigs is unclear, as is the nature of the genetic changes that are required for (a) efficient replication of an avian virus in pigs, (b) efficient transmission of avian viruses between pigs and (c) virus transmission from pigs to humans and between humans. The FLUPIG consortium will examine both the role of adaptive mutations and genetic reassortment. In addition, we will study the role of host and environmental factors in adaptation of avian influenza viruses to pigs. The occurrence and severity of a pandemic also depends on the immune status of the human population. The FLUPIG consortium will study the extent of cross-protection between antigenically different influenza viruses of the H1N1 subtype (heterovariant cross-protection), and between influenza viruses belonging to different haemagglutinin subtypes (heterosubtypic cross-protection). We will also study the immune mechanisms required for a broad cross-protection. In addition, we will evaluate the capacity of novel generation vaccines to broaden cross-protection. Most studies will be performed in pigs or other relevant animals, or in explants of the porcine and human respiratory tract, which show maximal similarity to the in vivo situation. Our studies will enable us to advice public health authorities about the role and risk of the pig in the emergence of novel influenza viruses in the human population. Combined with improved surveillance for influ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'NAnopatterning for Thermal Engineering in Layered Materials'.

assistant: **Objectives**

As modern devices shrink, thermal management become increasingly critical. The need for better understanding and control of thermal transport at the nanoscale thus arise and has been in the spotlight for several years for semiconductors such as silicon in particular. Recently, layered and 2D materials have been the focus of much research for their promising optical and electronic properties, and will be the core of many future devices in the field of Information and Communication Technologies. Their thermal properties need to be understood and controllable. Due to experimental challenges, they have remained largely unexplored. We propose the first experimental realization of thermal and phononic devices in 2D and layered materials that are expected to function at temperatures exceeding 300K. Our approach is based on engineering defects, pores or inclusions, in suspended 2D materials by focused ion beam and electron-beam lithography. These method would allow fabrication of desired (periodic, asymmetric, gradient) patterns with close to atomic precision and characteristic length scale of ~10 nm. That is smaller than the mean free path and coherence length of phonons in materials such aWe propose the first experimental realization of phononic devices in 2D materials that are ex-pected to function at temperatures exceeding 300K. Our approach is based on engineering de-fects in suspended 2D materials by focused ion beam. This method would allow fabrication of desired (periodic, asymmetric) patterns with close to atomic precision and characteristic length scale of ~10 nm. That is smaller than the mean free path and coherence length of phonons in materials such as graphene. This would provide fundamentally new opportunities to study ballis-tic and coherent thermal transport ph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Active biomimetic systems' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

The STREP proposed here deals with biomimetics at the supramolecular or subcellular level which covers the nano- and microregime. In this regime, biological systems exhibit many active processes which are driven by a variety of biomolecular nanomaschines o r motors. The biomimetic systems studied in this STREP contain two types of linear motors, growing filaments and stepping motor proteins. Growing filaments generate pushing forces, stepping motor proteins exert pulling forces. The project has several scien tific objectives: to understand the molecular processes which are responsible for the generation of these forces; to elucidate the cooperative behavior of small and large groups of motor molecules which lead to active surface layers and active filament ass emblies or scaffolds; and to control and optimize the properties of these biomimetic systems. The research performed in this STREP is at the cutting edge of science and has a high potential for long-term innovation. Indeed, there are many possible applicat ions in bioengineering, pharmocology, and medicine such as sorting devices for biomolecules and biocolloids, active drug delivery systems, and force generating components for the development of nanoscale manufacturing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Data in context: standardization of Metadata and theoretical perspectives in biodiversity research' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

As huge budgets and attention are being deployed to construct a global standard for biodiversity metadata, it should not be simply assumed that its data is robust enough to sustain inevitable metadata changes through time, and that at each point in time a single metadata standard is the best way to advance biodiversity research.This research attempts to examine these assumptions by closely tracking the correspondence between data, metadata and theoretical perspectives in important cases conducted by leading scientific figures, in different time and places, and in that sense its finding are likely to be relevant, and perhaps revealing, for other cases as well.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ethical, legal and social aspects of fisheries management in Europe' in the context of a Fourth Framework call.

assistant: **Objectives**

The central objective is to discuss the difficulties associated to the present state of fisheries management centrally based on biological, economic and political considerations in a top-down decision-making process. It is true particularly with the EU common fisheries policy which is today much criticised The criticisms and debate for future reform focus on the following needs:a more open view of the possible property right structure and regulatory means to reach fisheries management objectives;the rethinking of decision-making processes for a more participatory approach to policy-making;the balancing of bio-economic considerations with the social aspects linked to fisheries management impact;the introduction of environmental concerns both in terms of long term objec- tives based on environmental ethic consideration (conservationism or even ecosystem restoration) and for shorter term objectives of balancing the interests of interacting user groups (integrated coastal management policy).The analyse will focus at the identification of actors of fisheries management systems" and their links in the process of decision-making. The perception of the above mentioned aspects by the main acting groups (fishermen, administration, research and politicians) of the limits of present legal frames and of the needs for the future will be the core of the research.ELSA - pêche is a policy analysis multidisciplinary research project."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated cascades of PROcesses for the extraction and valorisation of proteins and bioactive molecules from Legumes, Fungi and Coffee agro-industrial side streams' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Agro-industrial residual biomass, side streams and food production by-products like legumes, fungi and coffee are potential sources of valuable ingredients even though the routes for their exploitation are still at an early stage.Pursuing the ambition of achieving prolific valorization of untapped biomass streams, the project R%D&I activities and partners of Prolific have been positioned around a central innovation cycle that is mainly driven by industrial end-users who exactly know the needs of their customers and the technical constraints and industrial environment in their respective sector.The PROLIFIC project will apply a range of processing technologies to recover significant amounts of proteins/peptides and other value added compounds (e.g. carotenoids, phenols, caffeine and fibers) from industrial processing residues of legumes (seeds of peas, beans and chickpea), fungi (cuttings and mycelia of different species) and coffee (silver skin residue and not compliant roasted seeds). The economically and environmentally sustainable extraction, enzymatic modification, and conditioning techniques will be upscaled in industrially relevant environment. This will enable the production of consequent amounts of compounds and fractions necessary for the production of 16 product prototypes for the food, feed, packaging and cosmetic sectors.The Prolific project will assess the environmental, societal, ethical, safety, and regulatory issues at each step of the targeted value chains. SME and large companies strive at achieving competitive biomass exploitation and attracting when needed additional investors. The industrial partners business strategies for the future market penetration starts with the clear identification of the customer needs and goes up to the preparation of give
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Using smart contracts and policies to reduce energy-related risk and inequality among households'.

assistant: **Objectives**

To reduce carbon emissions, the green energy transition emphasizes incorporating variable renewable energy (VRE) sources and electrifying household energy consumption. This transition shifts households from being mere consumers to becoming producers and flexibility providers, playing a crucial in balancing VRE. The rise in energy prices due to the conflict in Ukraine has underscored a significant issue with this: while variable prices are vital for aligning demand with VRE supply, they also expose households to significant risks. These fluctuations contribute to inequality, as households' ability to absorb price shocks varies, which can undermine support for the transition. In 2023, 10.6% of European households struggled to keep homes warm, up from 6.9% in 2021, despite government measures like price caps. These interventions often lacked a solid data-driven foundation. To address these gaps, ENERPOL has developed an interdisciplinary research agenda focused on how households economically interact with energy systems during the green transition. This agenda will inform policies to mitigate inequality while preserving energy system efficiency.ENERPOL unites academic institutions from nine European countries with 16 non-academic organizations, including private energy companies, regulatory bodies, and think tanks. These collaborations enable unique data access, linking income and wealth data with energy consumption patterns. This consortium tests smart contracts and new policies, merging academic disciplines like operations research, economics, and energy studies. ENERPOL aims to provide insights for legislation, such as the EU electricity market reform, enhancing energy justice and aligning with European policy goals. This holistic view promotes energy justice, advocatin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Population level interventions to improve diet and reduce social inequality' (PIDS) under Horizon 2020.

assistant: **Objectives**

Addressing social inequality in diet and health is a major public health challenge; the socially disadvantaged have the poorest diets and die the youngest. A further cause for concern is that commonly adopted public health interventions may be inadvertently worsening social inequalities in diet. We therefore need to identify interventions that benefit all, but are particularly effective in improving the diet of the disadvantaged, as this approach will reduce inequality and be the most effective way of improving overall population health. By testing a novel psychological theory, across two work packages (WPs) I will establish the type of population level interventions that worsen social inequalities in diet and identify interventions that not only improve the diet of the overall population, but also reduce inequality. WP1 will test the new hypothesis that the social patterning of executive function results in information-based nutrition interventions benefitting the socially advantaged but failing the disadvantaged, whilst structural interventions benefit all and also reduce social inequalities in diet. In WP1 I will use newly developed immersive digital reality methods to study dietary choice and laboratory feeding paradigms to examine dietary consumption in the socially advantaged vs. disadvantaged, before conducting the first ever large scale randomized control trial to identify how the real-world implementation of information vs. structural interventions affect social inequalities in diet. WP2 will exploit the knowledge generated in WP1 in order to develop a state of the art epidemiological model to simulate how the implementation of different information vs. structural nutrition policy interventions would affect population level health and health inequalities in Eur