RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CeRTificaTion of FINREAD' (1998-2002).

assistant: **Innovation**

The project aims at providing the certification infrastructure needed to certify FINREAD applets to be downloaded in a FINREAD card reader. The certification process is carried out by GTA (Global Trust Authority). The proposal includes the actual demonstration of FINREAD card readers using applets developed by financial institutions participating in the project and signed by GTA.Objectives:The main objective of Trusted FINREAD project is to complement FINREAD and Embedded FINREAD initiatives by defining a certification architecture provided by GTA (Global Trust Authority). An additional aim is to construct a pilot of trusted FINREAD card readers based on GTA certification infrastructure. The proposed pilot aims at validating the complete FINREAD solution. A further objective of the project is to address the card reader acceptance process and the definition of an application scheme infrastructure to deal with the actual operation of forthcoming FINREAD compliant schemes (organisation of the scheme, validation of applets, applets signature, card readers type approval.Work description:The main task of the project consist of the organisation of the certification architecture needed to sign FINREAD applets.Two architectures are foreseen:- a test infrastructure to validate interoperability of applets and card readers;- a full-fledged infrastructure to manage the pilot.A pilot will be built according to the following procedure:- the development of FINREAD card readers' prototypes. These prototypes will be provided by card readers manufacturers belonging to the consortium (150 devices are provided);- the development of FINREAD applets. Financial institutions belonging to the consortium will provide these applets.A demonstrator of FINREAD card readers and applets interoperabilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Smart design of well-function algae-plant-based powder: green spray-drying, characterization and rehydration'.

assistant: **Concept**

Algae protein and plant protein are considered as novel and primary source of protein for the human being in future as it is now crucial to reduce our dependence on animal-based protein, notably to reduce greenhouse gas emissions. Also, among varied food structure, the powder matrix of the algae-plant-based formula will reduce transportation and storage costs due to lower water content, which is interesting for food industry. Moreover, the algae-plant-based powder can be a replacer to traditional dairy powder, which is namely milk-analogue powder. However, the formula of algae-plant-based solution and its powder has not been studied yet. This project therefore aims to 1/investigate the powder matrix of algae-plant based formula influenced by drying protocol, 2/demonstrate the rehydration profile of the powder matrix, and 3/improve the sustainable production of this powder. Technological and health potentiality of plant and algae protein for the production of functional food powders by spray drying will be investigated focusing on milk-analogue powder as a model. To achieve the sustainability of the process, mass and energy transfer will be modelled to identify optimal conditions for greener production. The physical characteristics of algae-plant-based initial liquid feed and final powder will be investigated. Both are linked and are of great significance on the development of powder structure during drying and on the final powder functional properties. Especially, the rehydration of algae-plant-based powder will be studied stepwise in comparison with the characteristics of feed solution and spray drying conditions, which can enlighten the smart design of powder matrix for instant breakage during rehydration. Lastly, the digestion of algae-plant-based powder and nutritio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project '(W)Initiative for womeN and GirlS affected by Female Genital Schistosomiasis' (WINGS-4-FGS) targeting Horizon Europe.

assistant: **Abstract**

WINGS-4-FGS addresses pressing needs for tackling Female Genital Schistosomiasis (FGS) in Africa, with the objective of improving case management and therapeutic access while integrating care into sexual and reproductive health strategies. FGS, a consequence of schistosomiasis caused by the parasite Schistosoma haematobium, affects millions of women and girls in sub-Saharan Africa, leading to significant morbidity and reproductive health issues. Current treatment barriers include limited knowledge, associated stigma, a lack of effective treatment, and inadequate diagnostic tools. WINGS-4-FGS proposes a multifaceted, holistic approach and aims to: i) investigate the efficacy of anti-inflammatory medications as add-ons to praziquantel; ii) implement training programs to increase awareness and medical care competency; iii) implement a community-based, two-step, self-sampling diagnostic strategy; iv) assess barriers and facilitators for integrating FGS into existing health services.  WINGS-4-FGS aims to generate evidence-based recommendations, enhance local capacity, and engage stakeholders and policymakers to integrate FGS care into African countries’ healthcare systems effectively. Success will lead to improved treatment guidelines and practices that will enable patients and healthcare workers to recognize, diagnose, and treat the disease before symptoms spread, as well as foster affordable local access to treatment and reduce associated stigma. The transdisciplinary consortium brings together 11 renowned partners with expertise in tropical disease research, coming from 3 European (Germany, Switzerland and United Kingdom) and 6 African countries: Democratic Republic of Congo, Côte d’Ivoire and Malawi, where the clinical trials will be conducted, as well as Ghana, Madagasc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Design, synthesis and biological evaluation of PROteolysis-TArgeting Chimeric (PROTAC) molecules as anticancer agents' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cancer diseases are critical medical problems - according to the International Agency for Research on Cancer and European Commission estimates, globally there were more than 18 million new cases and 9.5 million cancer-related deaths in 2018, what indicates that tumors are among the leading causes of death, worldwide. Traditional anticancer drug design based on small molecules continues to be a powerful strategy for the development of novel chemotherapeutics. However, these anticancer therapies are facing major problems such as drug resistance, especially in advanced cancers. This is mainly due to the alterations in the target, ineffective apoptosis or activation of different pathways, among others. The use of PROteolysis-TArgeting Chimerics (PROTACs) has become a promising approach to overcome resistance since they act degrading instead of inhibiting the target, with the advantage of reducing the systemic drug exposure and to counteract the protein expression that often accompanies inhibition of protein function. This approach uses bivalent molecules that possess a target protein recruiting group linked to an E3 ligase interacting moiety for protein degradation. The main goal of this project is to design, synthesize and evaluate a series of new small-molecule PROTACs, which will be able to degrade enzymes and receptors that are responsible for tumor development and progression. To address this aim, I shall carry out a fellowship at Universidad San Pablo CEU under the supervision of Prof. Beatriz de Pascual-Teresa and Irene Ortín from Faculty of Pharmacy. As part of this research, I shall carry out a secondment in the Department of Molecular Biotechnology and Health Sciences at University of Turin (Italy), and another one at the company CsFlowChem S.L. It is worth noting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'The role of adherence factors of Pseudomonas aeruginosa in the continous modification of the host/pathogen relationship'.

assistant: **Objectives**

Bacterial pathogens encountering host cells employ several attachment factors, which promote direct contact and trigger distinct signalling pathways in the host. The stimulation of particular signalling pathways subverts the eucaryotic cell and enables sur vival and persistence of bacteria within the host. Identification and characterisation of communicative tools between the bacteria and the host cells should lead to a better understanding of the infectious process and the development of new anti-infectious treatment. Pseudomonas aeruginosa is a Gram-negative bacterium causing nosocomial infections, wound infections, and lethal infections in Cystic Fibrosis patients. In the context of this proposal we aim at characterising the function of proteins encoded wi thin the P. aeruginosa cupB cluster, particularly that of the putative adhesins cupB6 and cupB5. The approach will employ cupB promoter studies to identify signals stimulating adhesion to eucaryotic cells. Expression levels of host cellular components upon infection with the wild type or cupB mutant strains will be analysed by high density DNA arrays. Cell lines with the Cystic fibrosis (CF) phenotype and Non CF cell lines will be used. Such an approach could be extended to other adhesins specific for epith elial cell - binding. The results will provide a specific profiling of gene expression and signalling pathways in response to the presence of particular adhesion factors in different P. aeruginosa strains.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Changing elites: how social and institutional change has altered the processes of elite formation over time?'.

assistant: **Concept**

Elites reveal the nature of inequality, allowing us to see the underlying structure of society. But, elites can also be the engines of inequality, driving forward changes ensuring the accumulation of power. So, when the people occupying elite positions change it says something about how the production of inequalities may have changed too. Most would agree (despite the paucity of data) that elites are different today than they were; but, what is contested is whether such changes signal a radical restructuring of the processes of elite formation. Two questions remain unresolved: 1) how has the composition of elites changed over time? and 2) did the major social, political, and economic upheavals of the last 200 years reconfigure elites through altering processes of elite formation? It has been difficult to answer these questions because of limited longitudinal data on elites. CHANGINGELITES will address these questions by creating a catalogue of the elite that is without equal in its empirical and temporal scope. This data set will combine information on education (schools and universities), club membership, parental wealth, economic capital, and family structure for around 120,000 people born since 1800. Alongside this data, we will also conduct 100 interviews with elites born in different periods, illuminating the varied trajectories that underpin this huge historical database. CHANGINGELITES will both shed light on the social composition of elites over time and seek to explain the changes and continuities within elites by exploring how institutional and policy shifts constrain and enable processes of elite reproduction. This ambitious, interdisciplinary study will radically alter our understanding of elite reproduction but, more than this, it will speak to a contradict
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Review of current stunning methods for cattle and sheep that avoid the risk of dissemination of brain particles into the blood and carcass, and maintain good welfare and operator safety (SAFESTUN)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

There has been increasing concern during recent years that stunning techniques using a penetrating bolt can cause embolic dissemination of brain tissue in cattle and sheep. In ranking various stunning methods according to the risk for, and possible level of, contamination the Scientific Opinion on Stunning Methods and BSE Risks, adopted by the Scientific Steering Committee on 10/11 Jan. ' 02, listed non-penetrative and electrical stunning as being of negligible or absent risk. Unfortunately, in commercial use these alternatives can present serious problems in regard to animal welfare and operator safety. With non-penetrating captive bolts systems there is a risk that some animals can be inadequately stunned, while the effect on others can be too excessive resulting in skull fracture. Present electrical stunning systems for cattle are expensive to install and again, in some cases, can result in animals showing signs of recovery. This review will commence with a detailed study of all available literature, which will be significantly enhanced through communication and discussion with the authors and research leaders. Stunning equipment manufacturers and slaughter experts will also be consulted, so that the study encompasses all available information and opinion, including that which is currently unpublished. A Technical Seminar will next be held in Europe, e.g. Barcelona or Brussels, where the preliminary results of the study will be reviewed with representatives of all stakeholders. Presentations will be invited from selected researchers, manufacturers and slaughter experts in both plenary and specific topic discussions, to ensure that the review encompasses both current practice and imminent improvements, and concludes with a consensus of opinion 20 copies of the final r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Trap for the novel control of horse-flies on open-air fields' to be submitted under Seventh Framework.

assistant: **Abstract**

Haematophagous females of tabanid flies inflict painful bites on horses, livestock and even people. Apart from the nuisance Tabanid fly presence lead to serious economic consequences. The blood loss of farm animals can reach up to 200-300 cm3 per day, which results in weakening and occasional death in livestock. Through interfering with animal’s natural grazing behaviour it also causes reduced productivity inasmuch as the milk yield and meat production decrease. Tabanid flies transmit over 35 diseases to livestock and even people, including flafellate trypanosoma that promotes health threatening conditions such as equine infectious anaemia (EIA), as well as other trypanosomes affecting cattle and sheep.  Protecting outside fed livestock, particularly in eco-farms that comply with bio standards is proved to be difficult, as at present there are no effective protective systems or biological methods available for controlling tabanids. Providing protection against blood-feeding horse-flies also pose a problem around outdoor swimming facilities or recreational resorts and camp sites located in close proximity of water resources.  The TabaNOid system will develop a passive fly trap using highly and horizontally polarized light that can be adjusted to meet the needs of territories of various sizes. The proposed system will meet all requirements of eco-farms and organic farmers as no polluting toxins or insecticides will be used. Investigation of tabanid behaviour and flying routes will help to develop passive traps that attract only a negligible number of other beneficial flying insects, eliminating almost exclusively tabanids, without having any serious effect on the area’s ecosystem, since there are very few natural enemies of tabanids. The TabaNOid trap system will also com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Chromatin Dynamics In Genome Integrity'.

assistant: **Innovation**

I have developed a research program that focuses on the role of chromatin in epigenetic inheritance and genome integrity. I am pursuing three lines of research both in the model organism S.cerevisiae and in human cells: First, I am exploring the role of chromatin regulatory factors in eukaryotic DNA replication. S phase is a precarious phase in the cell cycle and chromosome stability and subsequent cell proliferation depend heavily on the accurate execution of the DNA replication process. Therefore it is of major importance to understand the chromatin-mediated mechanisms that are essential for the maintenance of genome integrity during S phase. Second, I am investigating the mechanisms that control the propagation of the epigenetic information on chromatin. The epigenetic information as defined by chromatin structures influences the state and fate of the cell. My goal is to shed light on the mechanisms that control the proliferation of specialized chromatin structures during S phase. Third, I am investigating the effect of chromatin remodeling factors in aneuploidy in yeast and human cells. Aneuploidy is a hallmark for cancer and promotes tumorigenesis. My goal is to understand the role of chromatin remodeling factors in coordinating chromatin dynamics with cell separation, thus preventing aneuploidy and genetic instability. Focusing my studies on two model factors, the histone variant H2A.Z and the multifaceted ATP-dependent chromatin remodeling complex INO80, and combining high-throughput technology with the power of yeast genetics and the imaging capabilities of human cells, I plan to uncover novel pathways that are essential for genome stability and propagation of epigenetic information.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Music as an invitation: liveness in digital piano performances through participating audiences'.

assistant: **Objectives**

This research investigates participation in digital musical performances as a way to enhance a sense of liveness - i.e., the feeling of being connected to other people. For the last 18 months, digital concerts have become the norm due to the restrictions on social interaction during the pandemic. Yet such digital events often challenge the relationship between performer and audience by compromising the experience of liveness. Using Participatory Action Research methods, I will work with women and girls to collaboratively create online piano performances where I am the main performer.  Audience feedback and my own reflections as the performer, supported by literature review, will inform knowledge about the intensification of the relational and affective aspects of the music experience and its impact on the sense of liveness. My dual expertise as a musician (pianist) and qualitative researcher are essential here, as they allow me to undertake research both on and through the topic. By focusing research on audiences of women and girls I aim to address the specific lack of opportunities for these groups and challenge the traditional obstacles to participation in classical music. In this way the project will contribute to positive change towards more inclusive music practices for the post-pandemic and digitalised world. Research outputs will be a series of digital concerts which will be streamed via YouTube and music festivals, reflective short essays, two articles to be published in peer-reviewed journals, a technical handbook, and a book of personal reflections integrating researcher and audience perspectives. This research aims to innovate through applying ideas and methods from areas such as music performance, digital technologies, participatory arts, and gender studies.