RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Testing and maintenance activities supported by automated tools' (ATM).

assistant: **Concept**

The interest of SVIMSERVICE is to improve the quality of application software delivered and make the maintenance process more effective with respect to users expectation. This PIE will permit to introduce and formalise a new testing strategy aiming to reduce the overall development costs and increase user satisfaction. Moreover, the experiment results will contribute to improve the Quality System currently adopted by the company.The specific, measurable objectives for the experiment are following: to create skills and culture of software validation, to experiment techniques and methods for software testing, to introduce testing procedures, standards and automated testing tools.THE EXPERIMENTThe experiment will be conducted within an improvement scheme taking into account current status of people's technical skills, practices currently used to develop and manage software products, business goals and company commitment on implementing quality and productivity improvement programme. This improvement process will be tailored to the specific baseline project; in particular, the experiment will concentrate on the formalisation and automation of the aspects that mostly affect the testing phase following code implementation and during the evolutionary maintenance phase (regression test).The experiment will be conducted on a baseline project which foresees the implementation, the release and the maintenance of a software product for the Public Administration.SVIMSERVICE employs 168 peoples, 8 of them are involved in the baseline project.EXPECTED IMPACT AND EXPERIENCEThis experiment aims at significantly reducing this gap by transforming testing activities into a defined and repeatable standard process. At the end of the experimental phase we expect a general improvement in the t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular and Immune Mechanisms Underlying Bovine Lameness' (MIMUBLKO), addressing dissemination and exploitation.

assistant: **Impact**

Lameness is one of the most serious health and welfare disorders in the dairy industry. Research into the detection of, causes of, and treatments for lameness have focused on gait scoring and environmental effects on hoof disorders. However these methods have limited usefulness when it comes to early lameness detection. Gait scoring methodologies are subjective and have low repeatability, and hoof injuries only become visible 2 to 3 months after the initial insult to the hoof. Early and accurate lameness detection means overall prognosis and the welfare of cows is improved. Previous studies that have used a molecular approach to identifying biomarkers of lameness were confounded because the researchers did not differentiate between different types of hoof disorder, which have various aetiologies. Moreover, the studies did not attempt to determine whether any potential biomarkers would be useful for early identification of cows at risk of lameness. The degree to which lameness affects animal health may be influenced to a large part by leukocytes of the immune system. Neutrophils are phagocytic granulocytes of the innate immune system, are plentiful in bovine blood, and provide a crucial first-line defense against invading pathogens. Gene expression profiles in these cells are affected by stress (e.g. transportation stress). Cows display a physiological stress and sickness response to lameness, and thus investigation into the usefulness of changes in neutrophil gene expression as objective measures of lameness onset is warranted. Initially we will investigate changes in the physiological stress response and gene expression profiles in neutrophils of cows that have lameness caused by claw horn disorders. We will then investigate levels of expression of identified biomarker
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Enantioselective Organocatalytic Reaction Cascades of Substituted Pyrroles and their Application in Complex Alkaloid Natural Product Synthesis'.

assistant: **Objectives**

Tracking the footsteps of nature, organocatalytic systems allow the formation of highly enantioenriched products starting from simple achiral substrates. Within this context, enantioselective organocatalytic cascade reactions have emerged as a powerful tool for the design of complex molecular architectures in single-step conversions. During this Fellowship we intend, in a very early stage, to address new, straightforward and synthetically powerful enantioselective cascade reactions towards the complex perhydroindole ring structure; a saturated and functionalized 6,5-fused bicycle system which is present in several targets with significant biological activities.Specifically, our methodology will be supported by the development of new asymmetric, organo-catalysed Michael, Michael cyclization cascades of activated pyrrole substrates with α,β-unsaturated ketones. In this sense our proposal takes advantage of the chemical reactivity of activated pyrrole substrates, based on their high acidity, and therefore tendency to enolisation giving the tautomeric nucleophilic form. This species can react with electron deficient alkenes by means of an organo-catalysed Michael addition. At this point, favoring the optimal catalytic conditions, we have envisioned that the intermediate Michael adduct can undergo an intramolecular Michael addition cascade to afford the desired bicycle target.Highlighting the scope of our approach towards the perhydroindole ring core, we are aiming to accomplish the first total synthesis of Daphhniyunnine D, a complex and important alkaloid recently isolated from a shrub endemic of the Peoples Republic of China, and with a prominent cytotoxic activity against several tumor cell lines. The Fellowship will touch therefore contemporary areas of modern chemical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Measuring all cells of Drosophila development to reconstruct differentiation trajectories and understand the language of the genome' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

How the genome regulates the differentiation trajectories that instruct a single fertilised egg to develop into an adult organism is a longstanding question in biology. Here, high-throughput spatial transcriptomics will be leveraged to virtually measure all cellular states of the Drosophila melanogaster. The entire ten-day development of the fruit fly will be sampled with a four-hour interval, where the spatial gene expression of 1,600 genes will be measured in a serially sectioned fly at single cell resolution. The sections will subsequently be reconstructed into 3D models. This approach enables whole-body-biology where a complex measurement is taken of all cells of an entire individual and is here used to densely sample development.In order to reconstruct differentiation trajectories, the 3D fly models will be anatomically aligned between timepoints so that cellular states can be linked and transitions in transcriptional profiles can be studied. The spatial information will substantially simplify this challenge because progenitors and putative progeny will be in the same anatomical compartment. This will generate a 4D developmental model of the fruit fly that links cells, cell types, anatomy and differentiation in space and time.The 4D developmental fly and the cell type trajectories will serve as the manifold onto which single cell transcriptomics (RNA-seq) and chromatin accessibility (ATAC-seq) data will be integrated. Then, Gene Regulatory Network inference tools can be used to identify transcription factors and enhancer sequences that drive lineage decisions. Investigating the enhancer sequences will reveal how cell type specificity is encoded and how the arising complexity is regulated during development. This project will give a unique insight into development,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Biofuels Research Infrastructure for Sharing Knowledge II' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The vision of BRISK II is to establish a centre of excellence in the field of 2nd and 3rd generation biofuels via the uniting of leading European research infrastructures. Building upon the success of its FP7 predecessor, BRISK II Networking Activities will consolidate knowledge in the field, reaching out to a wide set of stakeholders and potential users. Databases generated within the project will serve as a valuable resource for academia and industry. The business plan will boost momentum beyond H2020 so that the research infrastructures can be utilised between framework programmes or even independently. Joint Research Activities will yield a manifold improvement in the characterisation of feedstocks for thermochemical and biochemical conversion processes, tying micro-scale and macro-scale phenomena in novel ways. Enhanced measurement techniques will lead to significant gains in process flexibility and reliability. New biorefining approaches are intended to explore novel process combinations, ones that cannot be tested without a concerted effort between project partners. Assimilated data and knowledge will be input to simulation tools for use in a broad spectrum of analyses. Transnational Access supports the biofuels research community through the availability of high-quality installations within a well-structured framework.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Research into high intensity accelerators and radioactive Ion production' to be submitted under Sixth Framework.

assistant: **Abstract**

We will provide training for young researchers in the domains of high-intensity proton and radioactive ion beams. Of high priority for future accelerators, these research areas offer excellent training possibilities in a variety of disciplines, such as bea m dynamics computer simulations and programming, radio frequency cavities, and ion sources including materials research and chemistry. High intensity accelerators are more and more of interest for different applications. At CERN the possible future upgrades for the Large Hadron Collider (LHC) will require more powerful injectors. Neutron spallation sources are becoming important for many domains like material science, and even for biology. Nuclear waste transformation and the production of radioactive isotop es with applications in basic science, even including cosmology, but also for biological and medical purposes are also future applications. Early stage researchers will be closely supervised by experts using state-of-the-art, and sometimes unique, equipment . Particular emphasis will be placed on direct, laboratory-based training. They will follow formal training courses in their specialized and related fields, and will be encouraged to attend a wide variety of other courses, colloquia and seminars. Work and training objectives will be clearly defined at the outset and regularly reviewed. The early stage trainees will be integrated in a multidisciplinary, international environment and will acquire transferable skills, which are highly valued also outside acade mia. The trainees will work in an international environment with close contacts to other laboratories. The opportunities provided by the EST scheme will allow more young researchers to be hosted, will extend CERN's training programmes to non-EU nationals, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Law, Governance and Space: Questioning the Foundations of the Republican Tradition' (SpaceLaw) under Horizon 2020.

assistant: **Objectives**

Administrative professionalization is the hallmark of a modern state, but its origins contain a dilemma. Why there were no offices in ancient Rome? How is it possible that it nevertheless formed the model for the Western administrative state? The purpose of this project is to challenge earlier research and to propose a new model of the Roman Republican governance that integrates domestic and private space and to reinterpret its links with the Republican tradition.The significance of these issues extends much beyond this: the development of administrative space in the European context amounts to nothing less than the emergence of the concept of public. Ever since Weber, the conceptual separation of the office and its holder has defined the European way of governance. The origin of this separation of public and private has often been seen in the Roman Republican state with its strict responsibilities, term limits and defined powers of its magistracies, who operated in open public spaces.Using unconventional methodological tools to challenge the conventional view, the project explores the social and cultural dimensions of legal and administrative space, transcending modern assumptions of public and private. Two main research questions explore the confrontation of ideas and their contexts from the Roman Republic to modern Republicanism:1) How the conflict between Republican ideals, political power and administrative practices transformed the spaces of administration?2) How this conflict changed the social topography of Rome, the public and private spheres of governance?While much of the earlier research on Republican administration has been constitutional, focused on sovereignty or the individual magistrates, this project advances a radical new interpretation through spatia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Organization of an international colloquium : integration and disease control" from 26 to 28 november 2002"' (INDICO) under Fifth Framework.

assistant: **Objectives**

The colloquium f irst of all aims to clarify and possibly redefine concepts and terminology regarding integrated disease control. Second, strategies and methods for integrated disease control will be reviewed and discussed focusing on the mutual interaction between health services and control programmes: i.e. both the impact on the disease and on the system will be taken into consideration. Third, it will review practical results of integrated strategies for the control of major diseases (such as Malaria, AIDS, Tuberculosis, Leprosy, Schistosomiasis and other helminths) in developing countries, and investigate ways of improving the documentation and dissemination of such experiences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fluctuations-driven Light and Acoustic Scattering mitigation for High-resolution imaging in dynamic environments' in the context of a Horizon Europe call.

assistant: **Objectives**

Optical imaging systems are central to modern life, from smartphones and autonomous vehicles to laser-based microscopes in biomedical investigations and clinical diagnostics. Yet, even the most advanced imaging systems are severely limited by random scattering of light in dynamic environments, from live tissues to rapidly varying fog. Recent breakthroughs in computational scattering compensation, including my own works, have allowed an unprecedented leap in capabilities: it is now possible to reconstruct crystal-clear megapixel-scale images through visually opaque turbid samples by computationally processing a set of scattered light frames captured under controlled illumination. However, current techniques are fundamentally limited by their assumption of static scenes: both the scattering medium and the target must remain fixed during acquisition, severely limiting their impact on practical applications.Here, I propose a new paradigm: to exploit scene dynamics as the source of information rather than trying to eliminate or outpace them. This is made possible by two unpublished insights: (1) that target dynamics can serve the same purpose as controlled time-varying illuminations; (2) that scattering dynamics can as well be mathematically equivalent to illumination or target variations. We translate these findings to two new formalisms: a “dynamic matrix” for dynamic targets, and a “dual matrix” for dynamic scattering. Merging these formalisms with the recent model-based computational correction techniques, it is possible to transform dynamic scattering from an obstacle to a source of information.Project FLASH combines experimental, numerical, and theoretical efforts to develop and apply these techniques across different modalities: from holographic and fluorescence imagi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Towards the design of new potent antiviral drugs: structure-function analysis of paramyxoviridae rna polymerase (VIRRNAPOLDRUGTARGET)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The ultimate goal is the design of new antiviral drugs that specifically interfere with the replication of virus members of the Mononegavirales order, which are responsible for human and animal life-threatening diseases with large socio-economic impact. The RNA-dependent RNA-polymerise (Drip) of these viruses, the replicas, has no counterpart in mammalian cells, what makes it an attractive target for antiviral therapy. Seven partners will perform a structure-function analysis of the replicas, its viral, and possibly cellular, cofactors, and of its unique template, the nucleocapsid, in the presence or absence of antiviral drugs. To increase the chance of success, three complementary virus models will be studied, the Measles, Respiratory Syncytial & Sendai viruses. The outcome will be a poly-erase toolbox' which will enable a panel of 5 European SME to model the replicas and its template from any related viruses and design new antiviral drugs & vaccine."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Predictive mechanisms in sensory-motor control - PredAction' in the context of a Sixth Framework call.

assistant: **Objectives**

This proposal addresses an exciting feature of the brain - its remarkable ability to interact with the environment by a highly adaptive sensorimotor system. We propose to identify major principles of that system that allow it to operate and adapt much more efficiently than the most sophisticated modern robots. We hypothesize that predictive mechanisms are a key feature of natural sensori-motor control schemes and propose to investigate these in a joint experimental and computational approach. We will examine natural human movements in virtual reality environments, in which the experimenter can control and alter visual and haptic inputs during motor performance. The psychophysical experiments will be complemented by collaborative efforts with theoreticians exploring predictive mechanisms in computational models of motor control, and with physiologists who will investigate predictive signals within neuronal activity. The project will contribute to clinical applications in two ways. First, by testing Parkinsonian patients in our psychophysical experiments, we will investigate how the proposed control scheme is altered in movement disorders. Second, our work is designed to contribute to an ongoing research collaboration aimed at developing neural motor prostheses a new research field that opens promising solutions to a wide range of motor disabled patients.The applicant will be hosted by members of the interdisciplinary centre for neural computation (ICNC) of the Hebrew University in Jerusalem, where she will collaborate with leading experts in the field of motor control. Through interaction with leading theoreticians, the applicant will deepen her proficiency in computational neuroscience. We expect this project to make a highly important scientific contribution to the fie