RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multi-scale mechanics of dynamic leukocyte adhesion' (MechaDynA) targeting Horizon 2020.

assistant: **Abstract**

Leukocytes, white blood cells, patrol the vascular wall of our vessels in search of sites of inflammation. In the so-called leukocyte adhesion cascade, leukocytes flowing at high velocities (up to mm/s) impact the vessel wall, roll at µm/s, and finally migrate at nm/s to the site of inflammation. They are thus subjected to mechanical forces from sub-msec to several minutes. Complete understanding of the physical processes behind leukocyte adhesion requires an approach over multiple length and time scales, from single protein molecules to the whole cell. This is far from being established due, in part, to the lack of techniques covering the wide range of length and time scales involved. We have recently implemented high-speed atomic force microscopy (HS-AFM) to perform force spectroscopy measurements on biological samples with microsec time resolution. The novel acoustic force spectroscopy (AFS) traps hundreds of particles in parallel allowing hours-long measurements on single molecules.MechaDynA proposes to develop and apply these two novel nanotools to allow force measurements on living cells with the goal of obtaining a complete, multi-scale picture of the physics behind the leukocyte adhesion cascade over the widest dynamic range (µs-min). This will require development of HS-AFM technology and coupling with advanced optical microscopy. We will probe the binding strength of single adhesion complexes, and membrane and cytoskeleton mechanics at physiologically relevant time scales not explored so far. Technologically, it will establish HS-AFM and AFS as force measurement tools for living cells covering the widest temporal range. This will open the door to unexplored physical phenomena in cell biology, biological physics and soft condensed matter. Biomedically, the expec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structure and dynamics of clusters' to be submitted under Fourth Framework.

assistant: **Abstract**

The principal aim of this approach is to develop a detailed microscopic theory of nucleation using density functional theory. We will implement a perturbational density functional approach using a direct expansion of the density and optimise a Helmholtz free energy functional. Hence we will characterize the critical nucleus from which nucleation occurs. We will construct the free energy functional from thermodynamic perturbation theory, and calculate surfaces of free energy as a function of pressure and the number of particles. A direct comparison with the experimental rates of nucleation is possible for many simple atomic and molecular materials. An alternative approach based explicitly on the potential energy surface will enable us to compare the predicted rates. Nucleation is of great importance in processes ranging from catalysis to atmospheric chemistry and so there should be a variety of applications for our results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nanoscale processes in soils: The role of mycorrhizal fungi in aggregation and phosphorus acquisition' (NanoSoil).

assistant: **Innovation**

Healthy soils containing sufficient mineral nutrition for plants are the basis for our natural ecosystems and food production. Nevertheless, a great proportion of our European soils are subjected to erosion and are infertile. For a better management, we need to better understand the mechanistic processes happening in soils at a nanoscale. Symbiotic arbuscular mycorrhizal fungi (AMF) are important for both soil aggregate built-up via their extensive hyphal network and protein production; and supply their host plants with nutrients, especially phosphorus (P). I will study the dynamics of soil aggregation with a rare earth element labelling approach, and the protein structure of AMF derived soil macroaggregates with the help of synchrotron radiation based microscopy. AMF produce a protein called glomalin which is highly correlated with soil stability, but we do not know the microscale role of this protein in soil aggregation yet. Concerning a sustainable P nutrition of plants, I will examine the role of AMF in acquisition of P from minerals and biochar. For this, I will apply Fourier-transformed infrared microscopy, with which I will measure removal of phosphate out of a thin surface layer on the Goethite and biochar. Concluding, I will evaluate possible consequences for soil management and soil ecosystem functioning.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Fuel Cell Testing and Dissemination'.

assistant: **Concept**

The FCTEDI project is exclusively concerned with the dissemination of results in fuel cell testing, quality assurance and safety of fuel cells especially efforts on harmonization, benchmarking and validation of a collection of test protocols, testing procedures and measurement methodologies to facilitate standardization in the field and to analyse meta-gaps in this area. FCTEDI is the natural successor to the FCTESTNET thematic network and the FCTESQA STREP, which has recently become an IPHE recognized project.These two previous projects have respectively first defined and then validated harmonized testing procedures for fuel cells in order to overcome barriers towards fuel cell deployment. FCTEDI will disseminate results to the established IPHE framework and to international organizations such as the IEA, ISO and IEC. Furthermore, it will perform a Meta-Gap" analysis for Regulations Codes and Standards for stationary fuel cells. The goal of this analysis is to identify the gaps in RC & S that are beyond the scope of the currently existing gap-analyses, and it will complement to these activities. This study will be performed with the participation of the IPHE community."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Some mathematical problems in the design of ultra fast optical transmission lines' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

It is planned to consider various regimes of parameters entering into different perturbations of the scalar and the vector nonlinear Schroedinger (NLS) equation. These perturbations correspond to different configurations in the operation of optical transmission systems. Analysis of the equations will proceed via (hamiltonian) averaging and by a perturbative inverse-scattering approach with the aim of contributing to the optimal design of optical systems.  It is planned to study dispersion-compensated transmission and wavelength-division-multiplexing (WDM). It is planned to investigate some of the consequences of allowing some of the system parameters to become random variables so as to model the random distribution of repeater stations in the present european network. It is also planned to seek to make use of a technique known as self-consistent reflectionless potentials in order to find physically interesting new solutions to the vector NLS, with a view to their application in WDM systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Food Globalisation in Prehistory' (FOGLIP) targeting Seventh Framework.

assistant: **Abstract**

Each of today s major food species is distributed worldwide. While much of that food globalisation has resulted from modern trade networks, it has its roots in prehistory. By the end of the second millennium BC, the south west Asian crops, wheat and barley, were in several parts of China, and Chinese millets and buckwheat were in Europe. There was a parallel exchange of crops between South Asia and Africa. A series of later episodes of globalisation involve exotic fruits, vegetables and flavourings. This earlier phase would appear to involve instead staple starchy crops. Moreover, the movement of these starchy crops seems to precede other forms of evidence for cross-continental contact, such as is reflected in artefacts. What prompted this early globalisation of starch crops? How did it relate to the way in which humans societies were changing, and to the development and evolution of the crops themselves? These are questions I shall address through an archaeogenetic approach, which will modern methods of bio-archaeology and crop genetics. The focus of my bio-archaeological research will be selected sites in West China and Kazakhstan, chosen to complement ongoing research elsewhere (by a number of different groups) and to fill a critical geographical gap in the growing bio-archaeological record of Eurasia. For my genetic analyses I shall target upon two crops, one whose movement in prehistory was from west to east, the other form east to west. Of the various crops that moved in this way, I have chosen barley and foxtail millet chosen on the basis of i) their archaeological record of domestication and spread; ii) their genetic suitability for study, and iii) the timeliness of studying them in relation to contemporary research around the world today.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MATERNAL AND INFANT SAFETY AND IMMUNOGENICITY IN A PHASE 3, OPEN-LABEL, RANDOMISED, VACCINE TRIAL OF A TWO-DOSE MPOX VACCINE', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Mpox can cause severe complications in vulnerable groups such as pregnant women and children, necessitating targeted public health interventions and vaccine trials in these populations. Limited data suggest the MVA-BN vaccine is safe for pregnant women and likely poses no risk to breastfed infants, but comprehensive human data are lacking. Trials in endemic areas are crucial for evaluating the vaccine's safety and efficacy in real-world settings.Vaccine hesitancy, exacerbated by misinformation and distrust in healthcare systems, poses a significant challenge, especially in the Democratic Republic of the Congo. Pregnant women are particularly affected by concerns about vaccine safety, which influences their willingness to vaccinate. Addressing these concerns through targeted communication and community engagement is vital.A proposed phase 3, randomized trial will assess the safety and immunogenicity of the MVA-BN vaccine in healthy pregnant and postpartum women and in infants/children (6-24 months old). Additionally, a qualitative study on vaccine hesitancy will inform the trial design and implementation, aiming to enhance vaccination uptake in these high-risk groups.


**Keywords:** Pregnancy, Infants, children, vaccination, pre-exposure, post-exposure, Phase 2, Mpox
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel tumor-selective lethal miRNAs for the treatment of head and neck cancer' (MIRACLE) targeting Seventh Framework.

assistant: **Abstract**

MiRacle focuses on the development of a therapeutic formulation for the treatment of head and neck cancer. Head and neck cancer contributes to approximately 5% of all cancers in the Western world. Unfortunately the majority of H&N cancer patients present with advanced stages of disease. These patients frequently develop locoregional recurrences, distant metastasis and/or second primary tumors resulting in 5-years survival rates of less than 60% The development of novel anti-cancer agents to improve outcome is therefore urgently awaited. The goal of MiRacle is the advancement of a therapeutic tumor-killing miRNA formulation towards the clinic by combining two innovative technologies, i.e. therapeutic miRNA and head and neck tumor specific targeted drug delivery. Such a project requires (1) expertise in the therapeutic application of miRNA (InteRNA) and knowledge on the synthesis of biochemical active miRNA (Biospring), (2) knowledge of drug formulations to deliver the therapeutic miRNA into humans (IC) and understanding the synthesis of complex drug formulations (Polymun), plus (3) in-depth knowledge of the therapeutic indication, e.g. H&N cancer (VUmc) and skilfulness in toxicity tests that are required for RNA based drug registration (LPT). We believe that this project encompasses all parties that are required to successfully bring a tumor killing miRNA towards registration for first in human testing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Multi point aerodynamic shape optimisation'.

assistant: **Concept**

The assessment and enhancement of aerodynamic optimisation methods based on the solution of the Euler and Navier-Stokes equations will be carried out. This also includes the demonstration of the capability of the method to solve real life multi-point constrained aerodynamic design problems. The project is aiming at reduced design time and costs, and reduced time-to-market strategies. Work contains the set-up of the web site and the database, baseline evaluation of the present day standard methods, improvement of the tools with respect to ad joint methods, stochastic methods, automatic differentiation, evaluation of the enhanced tools and exploitation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Invariant manifolds in dynamical systems and PDE' (INVARIANT), addressing dissemination and exploitation.

assistant: **Impact**

The goal of this project is to develop new techniques combining tools from dynamical systems, analysis and differential geometry to study the existence and properties of invariant manifolds arising from solutions to differential equations. These structures are relevant in the study of the qualitative properties of ODE and PDE and appear very naturally in important questions of mathematical physics. This proposal can be divided in three blocks: the study of periodic orbits and related dynamical structures of vector fields which are solutions to the Euler, Navier-Stokes or Magnetohydrodynamics equations (in the spirit of what is called topological fluid mechanics); the analysis of critical points and level sets of functions which are solutions to some elliptic or parabolic problems (e.g.eigenfunctions of the Laplacian or Green's functions); a very novel approach based on the nodal sets of a PDE to study the limit cycles of planar vector fields. With the introduction by the Principal Investigator, in collaboration with A. Enciso, of totally new techniques to prove the existence of solutions with prescribed invariant sets for a wide range of PDE, it is now possible to approach these apparently unrelated problems using the same strategy: the construction of local solutions with robust invariant sets and the subsequent uniform approximation by global solutions. Our recent proof of a well known conjecture in topological fluid mechanics, which was popularized by the works of Arnold and Moffatt in the 1960's, illustrates the power of this method. In this project, I intend to delve into and extend the pioneering techniques that we have developed to go significantly beyond the state of the art in some long-standing open problems on invariant manifolds posed by Ulam, Arnold and Yau
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biomolecule Sensing with Graphene-Integrated Nanogaps' to be submitted under Horizon 2020.

assistant: **Abstract**

Monitoring the DNA and protein composition of cells is key to understanding most biological processes, including the molecular origins of specific diseases. To this end, the emerging field of molecular electronics offers unique opportunities for label-free single-biomolecule sensing. In particular, tunnelling current modulations caused by trapping an individual molecule in a nanoscopic gap between two electrodes can be used to discriminate species based on their electronic structure. The junction conductance is highly sensitive not only to the structure of the molecule, but also to the gap size, the voltage applied, the bonding arrangement inside the gap and the immediate molecular environment. Mechanically controlled break junctions (MCBJs) that allow the formation of closely-spaced electrodes with picometer resolution, can exert a degree of control over each of these parameters and therefore represent an ideal platform for in-situ studies at single-molecule level. In BioGraphING, I will develop the first graphene MCBJ, a unique device that will be both a model system for studying charge transport in molecular junctions at room temperature, and a sensing platform for biomolacular fingerprinting. Graphene’s atomic thinness, chemical inertness and strong in-plane bonds will lead to a device architecture with superior mechanical stability and measurement resolution. Given that a robust and reliable contact to single molecules is crucial for high junction conductance, various anchoring modes of the molecules to the graphene electrodes will be investigated (e.g. covalent bonding, π-π stacking). I will monitor the molecular conductance as a function of electrode distance and bias voltage in air, vacuum and in liquid. Combined with quantum transport simulations and statistica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Thinking pandemic societies through metaphor: Language, crisis and coronationalism in the post-Yugoslav area' in the context of a Horizon 2020 call.

assistant: **Objectives**

Months into the Covid-19 pandemic, it is clear that global society is faced with an emergency of not only health, but of social mobilisationand communication, unfolding in paths we are only beginning to discern. Emerging research suggests that the pandemic is bringing a major reframing of notions of collectivity and national belonging, where a figurative, metaphorical political rhetoric is paving ways to sweeping  ‘coronationalisms’, across Europe. Certainly timely and appropriate, the academic and citizen interest in language of thecrisis points to public discourse metaphoricity as a new challenge for crisis research globally. By locating the analysis in the post-Yugoslav, post-socialist area, where persisting nationalist tensions mix with pandemic discourses in complex ways, this project lays the foundations for interdisciplinary, language-driven study of crisis discourse grounded in the role of metaphor for rooting perceptions of the past, present and future. The project thus addresses objectives on two levels: (1) exploring the (re)framings of collectivity, national belonging and nationalism in the post-Yugoslav political, media and citizen discourses, and (2) introducing a multi-dimensional metaphorical methodological approach to public discourse analysis, bringing together cognitive-linguistic metaphor study and social science study of politics, history and cultural memory, as an adaptable interdisciplinary model suited to approaching discourses of crisis and social transformation. The analyses, methodology and dedication to public debate together are expected to pave the way to rethinking effective crisis communication in this and other looming crises,  by drawing on our pioneering insights on the conceptual role of language in mapping the real and symbolic borde