RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'An effective and safe targeted therapy for treatment of Myasthenia gravis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Myasthenia gravis (MG) is a rare disease affecting 2/10.000 people. Although being a rare disease, MG is the most common chronic autoimmune neuromuscular disease that causes weakness in the skeletal muscles, which are responsible for breathing and moving parts of the body, including the arms and legs. MG restricts patients from having a full participation in everyday activities, frequently leading to unemployment and reducing their quality of life. Many patients may eventually experience a myasthenic crisis, the treatment of which is very expensive. Such crises can lead to the death of the patient. There is currently no cure for MG and neither is there any cure in sight. Even though there are over 30 MG-related clinical trials currently in progress, most of them are only symptomatic treatments.Considering this urgent medical need, we are developing TOL2, an innovative therapy with potential to cure MG (not only symptomatic treatment). This will be the first therapy for MG that induces long-term remission. TOL2 is based on a tolerance-technology with potential to be developed for treatment of other autoimmune diseases. TOL2 has been granted Orphan Drug Designation by the US FDA.Toleranzia is a Swedish pharmaceutical research and development company. Our therapies utilize the immune system’s own intrinsic power to treat autoimmune diseases. Our mission is to develop innovative therapies that will cure autoimmune diseases.Our business strategy for TOL2 is to complete clinical phase IIa, and then to look for an agreement with a global pharma partner, who can or co-develop the therapy. Under this business model, revenue streams are obtained through upfront payments, milestone payments and royalties on product sales.Considering total project cost of €5,6 m during years 2019-2
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Next-gen fluorescence imaging for research and theranostics' in the context of a Horizon Europe call.

assistant: **Objectives**

Fluorescence microscopy is key technique in the life sciences, though the method struggles to deliver the fast and sensitive imaging of multicellular systems. Such samples are now becoming commonplace not only in research but also in clinical use, including spatially-resolved 'omics' and theranostics based on patient material that allow the development of personalized treatments. However, their general uptake is limited by the absence of suitable instrumentation.As part of our ERC-funded research, we have invented the TriScanner, a novel fluorescence microscope that offers transformative imaging performance (much faster imaging, higher resolution, higher sensitivity), and is also simple, robust, and affordable. Our TriScanner readily addresses an urgent need in current research and healthcare research, and is well-positioned to scale out from research into 'workhorse' usage in industrial R&D and diagnostics.We propose to develop this idea from a concept and lab prototype into a robust demonstrator that is showcased on a variety of highly-relevant applications, and that we will leverage to raise user awareness and interact with key leaders in academia and leading commercial partners. This project will furthermore allow us to explore the business case and market potential, in view of developing and selecting the optimal valorization track. We expect to deliver societal impact by providing unprecedented new imaging capabilities in a fast-moving and highly influential research field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ion-gated Interfaces for Quantum Phase Devices' (Ig-QPD), addressing dissemination and exploitation.

assistant: **Impact**

The aim of this ERC proposal is to develop a highly efficient tunable interface with ion-movement-mediated gating as a rich platform for novel electronic devices by using field effect controlling of quantum phase transitions. Working beyond conventional FETs, the new transistors will be build by combining novel layered semiconductor films grown by the CVD method: newly synthesized ionic material; and a well-defined interface optimized by surface analysis techniques; which jointly are able to boost the field effect control of carrier doping to the range required for switching quantum phases such as superconductivity in electrical transport, ferromagnetism in magnetization, and chiral or coherent light sources in optical applications.The sub-topics are designed to cover sufficiently broad disciplines of material sciences, new device technologies based on electrochemical principles, and condensed-matter physics. Such a design will make the project high adaptable for success at different levels with clear defined objectives to: 1) develop new materials and material combinations for ion gated interfaces to establish a rich platform of quantum phases; 2) utilize these quantum phases for device functionalities enjoying the characteristic abrupt response in phase transitions and to establish control of magnetism by field effect; and 3) create light emitting devices for effectively correlating light emission with quantum phases.The project represents an exciting new research field that is attracting the attention of many research groups around the world. The applicant is a well-established pioneer in developing this rapid growing and highly competitive field, where he achieved major milestones in design, fabrication and operation of quantum phase devices. Embedded in the strong
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Next generation of life Saving appliances and systems for saFE and swift evacuation operations on high capacity PASSenger ships in extreme scenarios and conditions'.

assistant: **Objectives**

Evacuating a large passenger ship is a safety-critical and strictly time-bound task and a complex decision-making process based on the evolving situation and the information available. Timely evacuation requires fast and accurate evaluation of ship’s condition and estimation of remaining evacuation time. The assumption that all passengers will be able to comprehend and follow instructions or even that the crew will be able to communicate verbally during a crisis is very optimistic. In response, a system that will provide clear instructions and guide passengers safely on how to react in an emergency situation without reliance on any passenger skills or experience is of paramount importance for any large passenger ship.SafePASS will radically redefine the evacuation processes, evacuation systems/equipment and international regulations for passenger ships in all environments, hazards and weather conditions, independently of the demographic factor, by developing an integrated system that will collectively monitor, process and inform during emergencies both crew and passengers of the optimal evacuation routes, coupled with advanced, intuitive and easy to use LSA, resulting to a significant reduction of the total time required for ship evacuation and increased safety. SafePASS is an integrated solution that provides passengers tailored evacuation assistance, assists the crew by enhancing their situational awareness and ability to handle de-skilled equipment, while incorporating fail-safe processes for the evacuation procedure.  SafePASS prototypes will be validated in real environment, on a cruise ship and in LSA manufacturers testbeds and towing tanks. The consortium, consisting of 15 partners, amongst which academic institutions, classification societies, innovative SMEs, s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Genomic stability -chromosome segregation and repair' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

The eukaryotic genome combines a highly dynamic nature with stable transmission of genetic information from mother to daughter cells. This is achieved by a plethora of protein networks regulating processes such as chromosome duplication, segregation and repair. The principal aim of our research is to determine the molecular interplay between chromosome segregation and repair. Accurate execution of these two events is crucial for the maintenance of genome stability, which in turn is essential for life. Additionally, erroneous segregation or repair leads to chromosomal aberrations that are linked to tumor formation and human developmental syndromes. Thus, our investigations are not only crucial in a basic research perspective, but important also for the understanding of the causes of human disease. The research is based on the budding yeast model system, and combines genome-wide analysis of protein-chromosome interactions with cell-based experimental systems. Our investigations have until now revealed that chromosome segregation and repair are directly linked through two evolutionary conserved SMC (Structural Maintenance of Chromosomes) protein complexes, Cohesin and the Smc5/6 complex. The project now further explores the molecular details of this connection, bringing light into this unexplored area of research, and deciphering the cellular defense against genomic alterations connected to cancer and developmental diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovative Catalysis and Small Molecule Activation:Toward 'Green' Chemistry' under Seventh Framework.

assistant: **Concept**

My proposed research projects will focus on sustainable Organic Chemistry, including various aspects of (Asymmetric) Catalysis as a ‘green’ key technology.  This approach is relevant to the global mission of the European Union in that it aims at advancing fundamental science in view of a sustainable and environmentally friendly society.Significant further developments in the field of (Asymmetric) Catalysis rely on:(I) the discovery of innovative (chiral) catalysts,(II) the invention of unprecedented modes for the catalytic activation of strong bonds, and(III) the careful elucidation of the involved reaction mechanisms.In this context, my proposed research programs will contribute to the following exciting areas:(1) Exploration of (chiral) compounds bearing an element in its unusually low-oxidation or low-valent state, in order to develop innovative catalysts for (asymmetric) synthesis, e.g. unprecedented direct-type bond transformations.  This approach saves resources and minimizes waste production.(2) Exploration of (chiral) potentially ambiphilic elements, displaying ‘switchable’ acid–base reactivity, for the catalytic activation of strong bonds in small molecules.  This intriguing unexplored concept may be exploited in view of:(a) catalytic (asymmetric) reactions employing e.g. ‘molecular hydrogen’ and ‘carbon dioxide’ for effective ‘green’ material transformations;(b) ‘molecular hydrogen storage’;(c) ‘carbon dioxide fixation’.(3) Exploration of Organic Chemistry, particularly (Asymmetric) Catalysis, in water or alternative ‘green’ solvents (abundant & renewable), such as hydroxylated organic solvents (glycerol, propylene glycol, lactate esters), but also in view of uncovering unprecedented reactivities and unique selectivities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Molecular cloning of the pvx resistance gene nb in solanum tuberosum'.

assistant: **Concept**

Virus resistance in plants, like that to other pathogens, is often conferred by major dominant genes and can be described in tenns of gene for gene interactions between the host and the pathogen. Several genes have been identifled in Solanum species that confer resistance to potato virus X (PVX) . These include Nb and Nx, which confer hypersensitive response (HR) against group 2 and group 3 strains of PVX, respectively, and the Rx genes, which confer extreme resistance to most strains of PVX. The aim of this project is the cloning of the ND gene in order to study the molecular mechanism of natural resistance conferred by virus-host interaction and the processes activated in the resistant plant that lead to suppression of virus accumulation. An analysis of Nb resistance will be undertaken using a PVX group 2 strain and the Nb cultivar Pentland Ivory (genotype Nb nb nb nb). Nb is a single dominant gene, which has recently been mapped to chromosome V in potato, in a region where there is also another virus resistance gene (Ex2) and a Plytophtora infestans resistance gene. In order to obtain a high resolution genetic map around Nb, more than 2000 segregating progeny of a resistant self cross will be screened with flanking markers Plants with recombination events close to NB will be identified and the relationship between genetic and physical distance will be established. These recombinants will be used to order further markers generated by amplified fragment length polymorphism (AFLP) and/or bacterial artificial chromosome (BAC)-walking strategies. Finally, a large genomic library from cv Pentland Ivory will be screened to identify clones carrying the targeted gene. The identity of tile Nb gene will be confirmed by complementation in transgenic plants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Engineering of Nanostructures with Giant Magneto-Piezoelectric and Multicaloric Functionalities' (ENGIMA).

assistant: **Innovation**

Nowadays smart materials play a crucial role in the next-generation of intelligent devices and sensors, smart homes, autonomous devices, and robotics. Nanostructuring materials open up new horizons bringing in their multifunctionality and reduce the energy consumption. This reveals new scientific avenues and paves ways for breakthroughs in technology. Realization of structured materials with the strong coupling of electric and magnetic order and large multicaloric properties is a milestone for modern electronics and the gate for fascinating applications.  In this context, we develop the partnership within the RISE consortium ENGIMA, involving the academic partners from two EU Member States, France and Slovenia Third Countries Universities in Morocco and Russia the non-academic SME from Associated Country, Ukraine.  The network combines the complementary interdisciplinary and intersectoral expertise with established collaboration between partners and clear potential for skills transfer and exchange of knowledge, extended from fundamental to applied physics and from material chemistry to industrial nanotechnologies.  Consortium defined a research objective of exploring the nanostructures in a form of tethered magnetic 1-D/piezoelectric nanostructures and magnetic/piezoelectric superlattices to obtain new ferroic materials with giant magnetoelectric and multicaloric functionalities that have potential applications as magnetoelectric sensors and, telecommunication devices. This task will be achieved by joining the efforts through the staff exchange, sharing knowledge, innovation and by multidisciplinary training of the team of collaborating young researchers able to conduct the research and exploit its application to this new area.


**Keywords:** Nanostructures, magnetoele
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Role of adult-generated neurons in hippocampal network activity for stress integration and antidepressant effects' (NEUROGPLACECELLADS), addressing dissemination and exploitation.

assistant: **Impact**

Stress-related disorders, including major depression, represent the most leading cause of health problem worldwide and a large part of depressive patients remain insensitive to treatments. Hence, the uncovering of the relevant processes involved in these disorders is of crucial importance. Recent works suggest that hippocampal neurogenesis is involved in the pathophysiology and the treatment of these disorders. The ability of the adult mammals, including humans, to produce new neurons is a fascinating process that has generated considerable interests, but their precise function remains poorly understood. In this project, we aim to understand how the production of new neurons can influence hippocampal network activity and underlie antidepressant effects. We hypothesize that antidepressants, by increasing neurogenesis, may strengthen stress integration by improving the coupling between contextual information and emotional state. Accordingly, we will examine whether chronic stress, antidepressant and viral-mediated inhibition of neurogenesis in animal models can alter hippocampal cell activity, behavioral performance and stress system (HPA) activation in “emotionally-relevant” environments. A putative alteration of hippocampal activity in chronic stressed animals could be responsible for disrupted behavioral responses and emotional state, as occurring in depression. Inhibition of hippocampal neurogenesis will help to determine whether antidepressants require new neurons to reverse the detrimental effects of chronic stress on hippocampal activity, facilitating suited behavioral responses and recovery. In conclusion, investigating the specific contribution of hippocampal neurogenesis in these processes will be essential for the understanding of the normal brain functioning i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Integrated infrastructure initiatives for material testing reactors innovations'.

assistant: **Concept**

MTR+I3 is an Integrated Infrastructure Initiative to reinforce European experimental capabilities for testing material and fuel by : * building a durable cooperation between Material Testing Reactor (MTR) operators and relevant laboratories* maintaining the European leadership with up-dated capabilities and competences* improving and structuring services with coordinated developments and uses of existing MTRs* preparing the future European landscape by implementing Jules Horowitz Reactor (JHR) and subsequent complementary research reactors. MTR+I3 covers: - Networking Activities fostering integration of MTRs community (new Members, associated and candidate states, labs with no, small or large MTRs) involved in designing, fabricating and operating irradiation devices through information exchange, know-how cross-fertilization, exchanges of interdisciplinary personnel and professional training. The network will produce recommendations on irradiation device manufacturing and measurement practices. Transnational Accesses to the consortium MTRs will be prepared by proposing to the end-users in-pile qualifications of the developments performed in the frame of Joint Research Activities, before implementation in their programmes. The tests will be technically and financially assessed by a Transnational Access Committee. - Joint Research Activities focusing on developments and fabrication of innovative test devices improving existing MTRs experimental capabilities to address safety issues, ageing management & optimisation of current power plants, fast neutron reactors with associated fuel cycle (sustainability, actinide management), and technologies for high temperature reactors (hydrogen economy). These developments, reinforced by the networking, will give a direct impulse that