RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Organisation and regulation of the vitellogenin receptor gene in rainbow trout'.

assistant: **Objectives**

Research objectives end consent; Vitellogenin is a complex glycophospholipoprotein synthetized in the liver under estrogenic induction. It is transported by the blood to the ovary, where it is incorporated inthe growing oocytes by specific receptors to form the major component of the yolk. The host institution just cloned a vitellogenin receptor cDNA in rainbow trout, which opens new research avenues to approach at the molecular level the mechanisms underlying vitellogenin incorporation ration. Indeed, as any other gene, the vitellogenin receptor gene is controlled by a complex interplay of transcription factors acting on cis- elements of its promoter.The first year of the project will consist in cloning the vitellogenin-receptor gene by screening, suing the cDNA probe, a rainbow trout genomic library available in the host institution. Sequncing the resultingclones should then allow to study during the second year the cis-elements and trans-factors 'implicated in'the regulation of the vitellogenin-receptor 'gene promoter and to gain crucial ,and orginal information on the molecular basis of oocyte receruitement and development, a key step in (female gamatogenesis. It isexpected that the value of this research will not be limited to-the model species but will bealibi of general interest for other oviparous species: and the regulation of other (VIDL) very low density lipoprotein receptors  Training content (objective, benefit and expected impact)  The applicant will be able to improve her technical skills in a laboratory having expertise in most major current molecular 'biology techniques.'In addition, the applicant will benefit from exposure to many other aspects of fish physiology being studied in 'the host institution and other nearby laboratories (INSEAM and NRA units
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reconstitution of a Minimal Signaling-Active Plant Receptor Kinase Complex - Towards the Structural Determination of Ligand-Induced Activation Mechanisms' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Plasma membrane-localized receptor kinases (RKs) perceive diverse extracellular ligands, allowing plants to react to various stimuli. They function in signaling processes during all aspects of plants’ life, including development, biotic and abiotic stress responses as well as reproduction. In the last decade, a major paradigm has emerged that individual RKs have different biochemical functions. There are e.g. ligand-binding RKs, which require the formation of stable complexes with RK co-receptors in order to initiate signaling. In addition to this common mode of activation, it has been revealed that additional RKs can have regulatory functions within RK complexes, and that in planta several other proteins are part of these complexes to regulate – either positively or negatively – complex formation and initiation of downstream signaling. The proposed project aims to understand what the minimal components linking ligand binding to receptor activation and to the initiation of cellular outputs are. Furthermore, it has the goal to elucidate the structural mechanisms of receptor complex activation. To achieve this, two interconnected approaches will be pursued. The first will utilize protein expression in cell-culture to reconstitute the signaling pathway from ligand perception to activation of downstream targets. The second approach will use a cell-free in vitro expression system to reconstitute the complete RK complex in synthetic, membrane-mimicking nanodiscs. This will ultimately allow the analysis of ligand induced structural changes by cryo-electron microscopy within full length, membrane embedded RK complexes.The well-characterized RK FLAGELLIN SENSING 2 (FLS2) and its co-receptor RK BRI1-ASSOCIATED KINASE 1 (BAK1), which are core elements of the receptor complex media
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Next Generation of 2D-Nanomaterials: Enabling Supercapacitor Development' (2DNANOCAPS).

assistant: **Concept**

Climate change and the decreasing availability of fossil fuels require society to move towards sustainable and renewable resources. 2DNanoCaps will focus on electrochemical energy storage, specifically supercapacitors. In terms of performance supercapacitors fill up the gap between batteries and the classical capacitors. Whereas batteries possess a high energy density but low power density, supercapacitors possess high power density but low energy density. Efforts are currently dedicated to move supercapacitors towards high energy density and high power density performance. Improvements have been achieved in the last few years due to the use of new electrode nanomaterials and the design of new hybrid faradic/capacitive systems. We recognize, however, that we are reaching a newer limit beyond which we will only see small incremental improvements. The main reason for this being the intrinsic difficulty in handling and processing materials at the nano-scale and the lack of communication across different scientific disciplines. I plan to use a multidisciplinary approach, where novel nanomaterials, existing knowledge on nano-scale processing and established expertise in device fabrication and testing will be brought together to focus on creating more efficient supercapacitor technologies. 2DNanoCaps will exploit liquid phase exfoliated two-dimensional nanomaterials such as transition metal oxides, layered metal chalcogenides and graphene as electrode materials. Electrodes will be ultra-thin (capacitance and thickness of the electrodes are inversely proportional), conductive, with high dielectric constants. Intercalation of ions between the assembled 2D flakes will be also achievable, providing pseudo-capacitance. The research here proposed will be initially based on fundamen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Peer-To-Peer-Implementation-and-TheOry' under Fifth Framework.

assistant: **Concept**

Traditional centralised system architectures are ever more inadequate. A good understanding is lacking of future decentralised peer-to-peer (P2P) models for collaboration and computing, both of how to build them robustly and of what can be built. The PEPITO project will investigate completely decentralised models of P2P computing.It will:(1) study the use-models of P2P systems, that is how they are perceived by users and what new applications are possible;(2) develop the foundations of P2P computing, including formal foundations (calculi, proof techniques, security and resource models) and new distributed algorithms (for diffusing information and coping with multi-consistent views);(3) provide a language-independent distribution subsystem tailored for P2P computing and;(4) provide programming languages and platforms using this, showing that they are useful by implementing convincing demonstrator applications. Traditional centralised system architectures are ever more inadequate. A good understanding is lacking of future decentralised peer-to-peer (P2P) models for collaboration and computing, both of how to build them robustly and of what can be built. The PEPITO project will investigate completely decentralised models of P2P computing.It will:(1) study the use-models of P2P systems, that is how they are perceived by users and what new applications are possible;(2) develop the foundations of P2P computing, including formal foundations (calculi, proof techniques, security and resource models) and new distributed algorithms (for diffusing information and coping with multi-consistent views);(3) provide a language-independent distribution subsystem tailored for P2P computing and;(4) provide programming languages and platforms using this, showing that they are useful by imple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Validation of a novel antiviral drug candidate against influenza', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

With 3 to 5 million severe cases and up to 650,000 deaths per year worldwide, influenza viruses are not only major human pathogens, they are also a heavy economic burden to our societies. In addition, influenza pandemics can occur at any time with potential devastating effects in terms of lives and costs. Solutions to prevent infection, to treat severe influenza cases and to respond to a severe pandemic are currently extremely limited and rely on vaccination and on only few approved molecules. All these solutions have their limitations with respect to efficacy and all face the problem of viral resistance. Thus, the demand for new options against influenza infections is high. The World Health Organization (WHO) and influenza virus specialists agree that innovative and effective anti-influenza compounds with a reduced risk of viral escape are urgently needed. The main goal of this ERC PoC is to provide key data on a promising innovative therapeutic solution identified in the lab. Taking advantage of a powerful screening system we have developed during the ERC StG ANTIViR, we have identified a family of molecules as potent inhibitors of influenza virus (with IC50<100nM). The mode of action of these molecules is known and they actually target a cellular function essential to all influenza viruses. Preventing viral replication by targeting a cellular function is a novel approach, predicted to strongly reduce the risk of drug resistance. Importantly, one of our hits went through several phase II and III clinical trials as an anti-cancer agent, making this molecule a perfect candidate for drug repurposing. In this context, the specific objectives of this ERC PoC are: i) to further characterise and validate our best hit, in particular in commercial 3D human airway epithelial ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Integrating European embedded systems tools' to be submitted under Sixth Framework.

assistant: **Abstract**

The competitive advantage of European industry in embedded system design is constantly challenged by emerging as well as other industrialized economies. The leading edge must be strengthened by boosting productivity, mastering growing complexity, and maintaining high quality of embedded systems.The project INTEREST aims to overcome the current lack of integration and interoperability of tools for developing Embedded Systems software. The partners in the proposed project comprise a unique group of European tool vendors that jointly address the Embedded Systems design flow.The following capabilities will be targeted:- Mapping of a logical architecture, i.e. the structure of the control algorithms, to a technical architecture. - Analysis of Timing related objectives for System and Nodes- Tool integration along the V" development cycle, spanning all the analysis, system design, module design, implementation (including certified code generation), functional testing, module testing, system testing and requirements testingIt will achieve its aims by creating techniques for improved interoperability (the INTEREST development framework) between European embedded systems design, code generation and verification COTS tools, which could not previously been achieved:- SCADE from ESTEREL TECHNOLOGIES- ASCET and INTECRIO from ETAS- DESIGNER Pro from DECOMSYS- Dependable COTS code (such as UNIS hardware abstraction layer COTS)The project will develop novel techniques for system-level and node-level analysis of non-functional properties, such as Worst Case Execution Timing, Stack and schedulability.These Analysis tools from ABSINT, EVIDENCE and SYMTAVISION will be then integrated into the INTEREST development framework. INTEREST will thus contribute securing Europe's competitiveness and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Chemically synthesised novel compounds for the stabilisation of biologics' in the context of a Horizon 2020 call.

assistant: **Objectives**

Biologics are medical drugs produced using biotechnology, other than direct extraction from a native biological source. Many of biopharmaceutical products are subject to very strict production, storage and distribution requirements in order to preserve effectiveness and safety. Biopharmaceuticals stability is a key issue in assuring that these medicines maintain their quality, safety and full potency.  Once potency is lost, it cannot be restored, this means the biologic is wasted. ExtremoChem synthesises a line of novel compounds consisting of synthetic small organic molecules, from 8 to 12 carbons, that are able to stabilise proteins and other biological material by preventing their degradation under stressful conditions, such as higher or lower temperatures, pH, salinity, agitation under which they would otherwise degrade.  eXtremochem is suitable for a wide range of proteins such as mAbs, vaccines, insulins, interferins and etc. But ExtremoChem currently focuses on mAbs, such as Humira (for rheumatoid arthritis) & Neupogen (for growth of white blood cells), since they present a high value market. The eXtremochem compounds improve the stability of molecules in the most critical purification stages and protects biologics, preventing aggregation and increasing production volume by 20%. Furthermore, eXtremochem enables long-term storage of thermally sensitive biologics without the need for cold chain, thus bringing significant savings to biopharmaceuticals – 6.5% of their revenues. The Phase 1 project will allow ExtremoChem to evaluate the medicines’ degradation under the presence of the small organic molecules through several stabilization tests, prepare a feasible industrial scale-up plan, plan a sound Ph 1 clinical trial, elaborate the business scale up, and size the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Labour trajectories in UK and Spain. Analysis of capabilities in transitions using a mixed-method approach' (TRANSICAP), addressing dissemination and exploitation.

assistant: **Impact**

European labour markets are undergoing profound changes. Although the mode and extent varies between Member States according to national labour market regulations, there is a general trend towards non-standard forms of employment within the EU. The emergence of non-standard forms of employment is linked to a growing polarisation of wages and income and an expanding low-wage sector in many European countries. Theses tendencies have even been further increased by the effects of economic recession. The project aims to define and characterise trajectories before and after the economic recession of 2007 in Spain and UK. Then the project will investigate transitions between employment situations (with or without unemployment spells) as ""potential turning points"" that allow identification of the effective capacity for action by the individual and how employment and company policies increase or decrease the real set of options available to the individual.By means of a mixed-method approach that combine quantitative analyisis of trajectories and narrative biographies the main objectives of this proposal are to:- Identify quantitative trajectories based in transitions in UK and Spain. The analysis before and after ""economic recession"" will allow social and employment profiles to be defined in the two periods and identify main collectives in which economic recession has been a turning point in trajectories.- Analyze in both countries narrative biographies of workers with the social and employment profiles identified in quantitative trajectories to identify the role played by institutional, company and personal resources and conversion factors to increase or not capabilities in transitions.- Identify the main inequality axis regarding the real options for personal and professio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Charging network optimized for Light Electric Vehicles (LEVs)' (LEVs).

assistant: **Innovation**

Due to growing population with growing urbanisation tendency, transportation is a major burden for modern cities. In Europe, using cars (even electric cars) is not the most optimal way of individual travelling in cities, due to busy roads, constant traffic jams, and difficult parking. The spreading of so-called Light Electric Vehicles (LEVs) represents one of the best solutions to the current challenges of urban transportation. However, the major obstacle of the spreading of LEVs in European cities is the lack of charging networks, resulting in too short range of the vehicles. Our company, Servo Movement Ltd, aims to commercialise Servo PowerShare, a community electric power sharing system designed for charging light electric vehicles (LEVs) in the streets. In the current project we aim to perform a feasibility study, which is essential for our successful market entrance. The success of this project will facilitate the commercial introduction of PowerShare and promote the growth of our company.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Next Generation Computer Assisted Reasoning', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Galileo said that mathematics is the language of science. It is used to solve arbitrary abstract problems, underpinning hard sciences, technology and engineering. Automation of complex mathematical reasoning, discovery and large-scale formal proofs is today one of the greatest challenges in the fields of Automated Reasoning (AR) and Artificial Intelligence (AI). Compared to human experts, today’s main automated reasoning and theorem proving paradigms are severely one-sided: they largely lack the capability to combine learning, reasoning and conjecturing in complex feedback loops. There is solid evidence that such combinations are the key to building the next generation of advanced reasoning systems for mathematics, computer-assisted proof and formal verification.The NextReason project will create one of the world’s strongest teams working on such combinations. We will jointly develop (i) logic-aware learning architectures and neuro-symbolic methods for a range of automated and interactive theorem proving paradigms, (ii) novel AI approaches for learning-guided automated decomposition of hard reasoning problems, (iii) methods for automated formalization of human-written mathematics by combining learning-based translation methods with semantic methods such as type-checking and theorem proving, (iv) neuro-symbolic methods for synthesis of interesting mathematical objects, conjectures and explanations, and (v) autonomous systems and positive feedback loops interleaving learning, theory exploration and efficiently guided proof search to attack hard and open problems.The expected overall outcome is a new generation of strong architectures for reasoning and theorem proving, and their transformative effect on large-scale computer-assisted proof, mathematics and formal verificati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Forum for European Structural Proteomics' in the context of a Sixth Framework call.

assistant: **Objectives**

The main goal of the project is to perform a thorough assessment of the existing Structural Genomics and Structural Proteomics projects at the national, EC and worldwide levels. This will include the assessment of the existing infrastructures in Europe relevant to SG and SP, and their comparison with those active in the rest of the world. Finally the requirements in terms of thematic areas and infrastructures, especially of new EC members, will be evaluated. This SSA will result in staged publications, a complete register of the Structural Genomics and Structural Proteomics projects worldwide and a 'position paper? on strategic plans for a European policy in the area of Structural Genomics and Proteomics.