RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Transferability of urban logistic concepts and practices from a world wide perspective' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

TURBLOG_WW is designed from a complementary perspective for the work that is being promoted at the EU level by addressing urban logistics from a wider (geographical) perspective, focusing upon a worldwide level (in general) and on Brazil and Peru (in particular). Our main goal is to extend, expand and transfer the existent knowledge to other countries and thus effectively contribute for the overall objective of extending the research and knowledge dissemination between EU and Latin America.For that, the project will act as a coordination platform, gathering the experience to identify, generate and assess best practice solutions on urban freight initiatives, through the conduction of a set of case studies (which will be undertaken to identify best practices and to assess the lasting effects and impacts of previously projects and tools and to compare experiences between Europe, Latin America, Asia and Africa) and the promotion of workshops and site visits, based on which it is aimed to facilitate the exchange of information, raise awareness, disseminate and assess the potential to transfer and promote research results at the national, European and intercontinental levels.To ensure the accomplishment of that objective, TURBLOG_WW is organised along the following main lines: Network Coordination, Selected case studies, Business concepts and business models, Transferability , Urban logistic guidelines, Thematic workshops and Overall dissemination activities.Overall the core mission of TURBLOG_WW and its role in EU research can be synthesised as to put together past urban logistics experiences, analyse them carefully, extract and disseminate valuable information, supporting ongoing and future related initiatives and contribute to its transferability to Brazilian and Peruvian
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'GREENHOUSES HEATED BY GEOTHERMICAL ENERGY' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Exploitation of autochthonous geothermical resources as an energy source to control the inside temperature of five hectares of hydroponic cultivation. The innovative aspects of the projects are :- exploitation of autochthonous geothermical resources for heating greenhouses- Heating system aimed to directly irradiate heat to the plant.The expected energy saving is 1080 TOE/y equivalent to 84,7 Million of pesetas, and the payback time for the investment is 6,99 year.Project started in November 95. The results of the well initially considered was positive as to location of an artesian aquifer, but negative as to its anomalous temperature, which led to change the location of the project from the Tertiary Basin of Granada depression to the neighbouring and geologically similar, Tertiary depression of Guadix-Baza, located 90 km to the north-east of the capital of Granada, where there are two unoperated geothermal wells drilled in 1991, with a geothermal conditions as required, and owned by the Local Government of Zujar.Contact was established with the representatives of the Municipality who showed great interest and a positive institutional willingness to collaborate with Pydhesa in setting up greenhouses.Finally, after a long process of bureaucratic formalities with the different authorities - Municipal, Local Government, state and the Hydrographic Confederation of the Guadalquivir, Pydhesa signed the contract awarding the land and geothermal resources with the Local Government of Zujar on 25th June.The land where these greenhouses will be installed are at 1700 meters from the above-mentioned resource. Thus, technical reasons and geo-physical tests led us to the consideration of making an exploratory well in greenhouses site, in order to avoid a thermal drop on the way. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cartilage Healing Approach Merging Polymer InnOvation with Nature' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Cartilage injury afflicts over one million patients annually in Europe. Focal knee cartilage defects are as painful and limiting as osteoarthritis and can lead further degradation requiring total knee replacement surgery. Focal knee cartilage injuries are typically treated by bone marrow stimulation (Microfracture) which has limited benefit due to a high failure rate, poor longterm outcome and frequent required re-interventions. Alternative therapeutic products in the form of cellular/biologicals treatments have failed due to complexity and multiple surgery risks. With the promise of cell-based procedures not realized, the pursuit of an optimal treatment for symptomatic articular cartilage defects in the knee joint remains elusive. GelrinC is a simple, off-the-shelf treatment for focal injuries in the knee cartilage. It is a ready-to-use liquid cured in-situ by ultraviolet light to form a resorbable implant conforming to the shape and depth of the defect. Unlike other acellular implants, GelrinC wasdesigned to support the formation of hyaline cartilage through a unique Mode-of-Action: Formation of a cell barrier thus preventing migration of undesired cells into the defect. At the same time, GelrinC harnesses the established prochondrogenic potential of polyethylene glycol, its major component, to provide the right microenvironment for the body’s own stem cells to differentiate into chondrocytes. Due to the presence of the denatured human fibrinogen in GelrinC, the implant resorbs from the outside inwards and thus is gradually replaced with new hyaline-like cartilage in a synchronized process.GelrinC gained a CE mark in 2017 and it is regulatory ready for commercialization in Europe. The next steps allowing quick, successful market entrance are optimizing the production
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Mechanisms of skeletal muscle adaptation to exercise and their implications in health and disease.'.

assistant: **Concept**

Sedentary lifestyles have led to the increase of obesity, type 2 diabetes, and sarcopenia (decreased muscle mass) of the elderly. Skeletal muscle plays a key role in these conditions, and it is clear that exercise can be as effective as medication in treating some of these ailments. The adaptation of muscle to exercise involves the coordinated regulation of gene networks, whose products adapt muscle function to new challenges (e.g. increased contractility or oxidative capacity). We have identified several novel members of the PGC-1 family of transcriptional coactivators, which is activated by exercise and has the ability to regulate important gene programs in muscle. By studying the function of these new coactivators, we hope to further elucidate the mechanisms by which muscle responds to exercise. Differences in conservation of certain functional protein domains indicate that specific PGC-1 forms might simultaneously regulate gene transcription and splicing. We propose that changes in alternative isoform expression may be part of the switch from sedentary to exercised muscle. We will characterize these processes by using RNA-sequencing since this technique provides information about transcript abundance and sequence. This analysis of muscle adaptation to exercise will allow us to understand how, in response to work, muscle can positively affect so many aspects of human health. This knowledge will help us design new therapeutic strategies to fight metabolic diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Exploiting synthetic SH2-scaffolded receptoire libraries to profile cancer cells and to interfere with cancer-related phenotypes' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

A new biotechnological process, exploiting scaffold synthetic repertoires will be developed to profile cancer cells by polemics, interfere with cancer phenotypes, rationally design drugs. The selected scaffold is the SH2 domain, an interaction surface, which binds to phosphotyrosine (pie)-containing peptides. By random autogenesis of five critical residues in the domain we have created library theoretically able to bind every containing-containing protein. This library will be used toa) identify novel specificities of synthetic SH2 domains,b) molecularly dissect the SH2: pY-peptide interaction,c) purify novel pY-proteins,d) interfere with phenotypes such as proliferation, differentiation and apoptosis,e) profile containing patterns in cancer, f) develop peptide antagonists. The involvement of the SH2: pY interaction, in TK-mediated signalling, predicts application of this bioprocess to other pathological conditions, in addition to cancer, involving aproliferative/signaling component.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Adaptive Landing Gears for Improved Impact Absorption (ADLAND)' (ADLAND).

assistant: **Innovation**

The proposed project deals with evaluating the options for adaptive shock absorbers to be applied in aircraft landing gears. Analytical design procedures will be developed to simulate different potential design options and a best practice solution determined. The different hardware components regarding adaptive shock absorbers will then be developed and tested with regard to an adaptive landing gear model. The objectives of the proposed project are: to develop a concept of adaptive shock-absorbers -to develop new numerical tools for design of adaptive vehicles and for simulation of the adaptive structural response to an impact scenario -to develop technology for actively controlled shock-absorbers applicable in landing gears (two options: MR fluid-based and piezo-valve-based will be considered) -to design, produce and perform repetitive impact tests of the adaptive landing gear model with high impact energy dissipation effect. to design, produce and test in flight the chosen full-scale model of the adaptive landing gear. Typically, shock absorbers are designed as passive devices with characteristics adjusted to the most frequently expected impact loadings. However, in many cases the variation of real working conditions is so high, that the optimally designed passive shock absorber does not perform well enough. For example, the large variations in impact loads found under different landing conditions means that the full stroke length of a passive device will not always be utilised. In contrast to the passive systems the proposed research focuses on active adaptation of energy absorbing structural elements where the system of sensors recognises the type of impact loading, and activates energy absorbing components to guarantee optimal dissipation of impact energy.The term
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Neuromodulation of Oxygen Chemosensory Circuits in Caenorhabditis elegans' (ELEGANSNEUROCIRCUITS) under Seventh Framework.

assistant: **Objectives**

An animal’s decision on how to respond to the environment is based not only on the sensory information available, but further depends on internal factors such as stress, sleep / wakefulness, hunger / satiety and experience. Neurotransmitters and neuropeptides in the brain modulate neural circuits accordingly so that appropriate behaviors are generated. Aberrant neuromodulation is implicated in diseases such as insomnia, obesity or anorexia. Given the complexity of most neural systems studied, we lack good models of how neuromodulators systemically affect the activities of neural networks.To overcome this problem, I propose to study neural circuits in the nematode C. elegans, which is a genetically tractable model organism with a simple and anatomically defined nervous system. I will focus on the neural circuits involved in oxygen chemosensory behaviors. Worms can smell oxygen and they use this information to navigate through heterogeneous environments. This enables them to find food and to engage in social interactions. Oxygen chemosensory behaviors are highly modulated by experience and nutritional status, but the underlying mechanisms are not understood.I established behavioral assays that allow studying the modulation of oxygen behaviors in a rigorously quantifiable manner. I also acquired expertise in micro-fabrication technologies and developed imaging devices to measure the activity of neurons in live animals. The first two aims of this proposal focus on the application of these technologies to study (A) how neuropeptides mediate experience dependent modulation of oxygen chemosensory circuits; and (B) how food availability and nutritional status modulate the same neural circuits. Aim (C) is an innovative engineering approach in which I will develop new microfluidi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Reversibly photocrosslinked BIO-based composites with barrier properties from industrial by-products' (ComBIOsites).

assistant: **Innovation**

ComBIOsites aims at developing recyclable composite materials for packaging, using (i) raw materials issued from bio-based industrial by-products, according to the principles of circular economy, (ii) environmentally friendly processes, such as photopolymerization. This project is fully aligned with the European primary goals for the promotion of a “green” society, with a sustainable and resource efficient economy, by key actions such as the development of new and improved materials with reduced environmental impact, from sourcing and processing to end of life. Cellulose is an abundant, renewable and sustainable biopolymer, plus it is biodegradable. Microfibrillated cellulose (MFC), obtained with top-down approaches from cellulose sources, forms excellent gas barrier films ; however, their high hydrophilicity prevents their use in highly humid environments. It is therefore convenient to combine MFC with polymers in the form of composites. Crosslinked matrices guarantee high mechanical performances and water and solvent resistance. The uncured prepolymers can have very low viscosity, which allows for solvent-free mixing at room temperature. However curing often hinders recyclability. Reversible photocrosslinking of bio-based prepolymers, combined with MFC to obtain recyclable composites is innovative. To fulfil the final goal of the project, I will use MFC obtained from hemp hurd, a low cost by-product of industrial hemp decortication process, and a bio-based prepolymer, functionalized with a reversibly photocrosslinkable group, able to ensure the curing of the polymeric matrix upon irradiation at a given wavelength, and to allow its dismantling upon irradiation at a different wavelength. Thus, through appropriate matrix-filler combination and processing, I plan to obtai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Specificity, polymorphism and regulation of the toll-like receptor (tlr)-based innate host defense signal transduction system'.

assistant: **Concept**

Toll-like receptors (TLR) sense the microbial presence. Tars promote expression of genes encoding ant microbial compounds via activation of the NF-cob signalling cascade. The aim is to resolve the specificity, polymorphism and regulation of the TLR4 and TLR2 signalling transudation system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'QUANTUM-TOX - Revolutionizing Computational Toxicology with Electronic Structure Descriptors and Artificial Intelligence' in the context of a Horizon Europe call.

assistant: **Objectives**

Toxicology is at a crossroads. With ever more drugs going to market and more chemicals having an environmental impact, the need for fast, cheap and accurate technologies to assess toxic effects is pressing. Computational toxicology provides an array of tools and methods for toxicity prediction only using computer approaches. Conceptually, computational toxicology has significant advantages since testing is fast and cheaper than in vitro. However, currently computational toxicology has severe limitations. Predictions typically use Quantitative Structure-Activity Relationship (QSAR) models that rely on large sets of molecular descriptors. This causes severe problems since the methodologies cannot assess chemicals different than the ones used to develop the QSAR models, and when that is possible, the very large number of descriptors limits understandability. Therefore, new methodologies are needed to address those shortcomings. This project will develop a new type of descriptor, totally based on quantum mechanics that can cover the whole chemical space and relies on a small number of parameters that are easily interpretable. Starting with meaningful chemical perturbations, that extract the behaviour of the chemicals in assumed mechanisms of toxic action, the approach will develop specific Electronic SIGNatures (ESigns). ESigns are mathematical invariants that map the results of the quantum chemical calculations. Using Artificial Intelligence, the ESigns will relate to toxicity. The new approach introduces a momentous change in computational toxicology. It can cover the whole chemical space, since we are abandoning predictions based on molecular structures, uses fewer parameters, and can be related to the new trends in toxicology regarding use of pathways information. In fa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Disarming bacterial weapons in the nucleus: functional study of Chlamydia nuclear effectors' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The high prevalence of Chlamydia infections and the heavy burden they inflict on public health justify the search for novel therapeutic approaches directed against this pathogen. Research on this obligate intracellular bacterium is very difficult, due to substantial technical impediments. One current challenge is to identify bacterial proteins that are required for Chlamydia to survive and proliferate in the host and that could serve as targets in novel therapeutic strategies. In particular, the identification of bacterial proteins implicated in the microbe’s ability to persist in host cells is highly desirable, since current treatments fail to erradicate the resulting chronic infections.Our project is focused on the bacterial proteins that are secreted into the host cell during infection and translocate into the nucleus. Our preliminary work has already identified some of these “nuclear effectors” of Chlamydia. Targetting the “central system” of the host, these proteins are likely essential for infection. We will (i) identify all Chlamydia trachomatis nuclear effectors and define their frame of action (in time and space) during infection, (ii) identify the targets of the nuclear effectors and their roles in infection and (iii) test the hypothesis that nuclear effectors are necessary for the entry into and/or maintenance of the persistent state of infection.Addressing for the first time the full repertoire of “nuclear weapons” of an intracellular bacterium, we will uncover new interactions between the pathogen and the host. This work will lead to the development of rationally-designed drugs that inhibit the activity of the nuclear effectors, thereby disrupting the microbe’s ability to survive in the host. Beyond this medical aim, our study, which lies at the interface b