RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nanoengineered particles for enhanced cancer radiotherapy' (ENCANT), addressing dissemination and exploitation.

assistant: **Impact**

Current cancer research efforts are focused on obtaining targeted therapies, with greater precision, that lead to improved patient survival, with fewer adverse effects to ensure a better quality of life. ENCANT (nanoengineered particles for ENhanced CANcer radioTherapy) will contribute to this aim by developing new therapeutic agents based on biocompatible nanoparticles bearing high atomic number (Z) elements, which will enhance external beam radiotherapy (EBRT) effect on cancer tissue. This will allow the use of a lower radiation dose, consequently lowering adverse effects related to radiotherapy lack of specificity.The physicochemical properties of the NPs can be rationally designed according to different needs. NPs will be functionalized to increase their blood circulation time and facilitate their accumulation in the tumoural tissue. NPs will be tested in vivo to describe toxicity ranges, targeting efficiency and their therapeutic effect with external beam radiotherapy using in vivo cancer models.ENCANT will initially focus on high-Z NPs for prostate cancer (PC). Nevertheless, their adaptability should allow to use them for other tumour types, thus expanding their range of application. ENCANT aims to improve and expand oncology treatment options available to cancer patients thus providing them a more personalized treatment.


**Keywords:** nanoparticlesbiomedicineprostate cancerexternal beam radiation therapy (EBRT)radioenhancers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ultrafast Raman Technologies for Protein Identification and Sequencing' (ProID) targeting Horizon 2020.

assistant: **Abstract**

The human proteome is the whole set of protein that a human can potentially express. Most of the human proteome is known. However the proteome, being the set of proteins potentially expressed, does not give information regarding the protein really expressed in a specific person or a patient. The possibility of accessing to this fundamental information through a cost and time effective technique will revolutionize our ability to prevent, diagnose and treat most of the human diseases. This is the commitment of ProID that aims to provide a technological platform able to record single protein Raman spectra with single amino-acid resolution. Namely, by reading the sequence of selected amino-acids along the protein chain, the platform will identify the corresponding protein. To reach this goal we want to combine advanced nanofabrications of plasmonic nanopores with ultrafast time resolved photon detectors and machine learning algorithms. More in details: i) plasmonic nanopores will be exploited to achieve single amino-acid optical excitation and enhanced Raman stimulation; ii) ultrafast and ultrasensitive Raman spectrometers will be obtained by combining the emerging technologies of SPAD (Single Photon Avalanche Diode) arrays with dedicated otpica elements which improve the sensitivity and the speed of the detector, and reduce the number of elements of the array necessary to sample a Raman spectrum; iii) bioinformatics approaches will complete the technological platform by developing specific software for discriminating the Raman spectra of proteins with reduced spectral points. Also, insightful experiments on electrophoretic translocation and augmented fluid viscosity in ultra-confined systems will contribute the molecular motion into the nanopores. Finally, to state of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Unpacking the “Black Box” of Orthographic Learning: Identifying the Foundational Skills Underlying Efficient Reading for English- and Greek-speaking Children'.

assistant: **Innovation**

Reading is the single most transferable skill taught in the elementary school years; it is the foundation for academic learning, economic contribution, and societal participation. Decades of research shows that efficient reading relies on precise mental spelling representations of individual words. These orthographic representations enable children to recognize words by sight, releasing cognitive resources for understanding what they read. Orthographic Learning (OL) is widely considered the mechanism through which readers build orthographic representations and develop efficient reading. And yet its foundational skills have not been established, a gap in knowledge that severely limits our ability to teach children the skills they need to achieve efficient reading. LEXIS will identify the foundational skills of OL and, in turn, efficient reading, so that we can develop effective instruction. LEXIS is a large-scale cross-language longitudinal study, following children from preschool through grade 2. Through LEXIS, I will establish the foundational skills of OL for both typical and dyslexic readers; results for typical readers can be applied to whole classrooms and results for children with dyslexia will be the basis for effective teaching for children with the most intractable reading difficulties. I will conduct this study with two distinctive languages: English and Greek; their similarities and differences will ensure that results can be applied across the diversity of European languages. LEXIS takes an interdisciplinary approach, bringing together educational psychology, special education, and psycholinguistics. Data will be analysed with cutting-edge statistical and computational modeling approaches. Through LEXIS, I will identify which foundational skills most strongl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Advancing Trans-Regional Border Studies'.

assistant: **Concept**

The project positions Tallinn University (TLU) to become a leading institutional and intellectual platform for scholarly exchange on border studies, in partnership with the University of Eastern Finland (UEF) and the University of Amsterdam (UvA). The uniquely designed Eur-Asian Border Lab, to be established and anchored at TLU, will become a platform that catalyses trans-regional conversations and synergies between the Euro-American and Asian border scholars, and addresses the contrast between bordering as an increasingly complicated conceptual process and the more straightforward policy-oriented approaches to borders. The Eur-Asian Border Lab through its online and offline activities will investigate bordering across the increasingly volumetric and virtual spaces, cross-fertilize research findings and reach out to practitioners, policymakers and the public. TLU’s vanguard position in advancing a trans-regional and multi-layered approach to understanding key social, political and environmental issues through bordering is expected to boost its scientific excellence, enhance its institutional capacity to administer research and improve access to new research collaborations. The partners, complementing each other in their strengths and research foci, will contribute key expertise and professional networks for knowledge mobilization, while engaging actively in the joint research activities, capacity building and attracting early career researchers.


**Keywords:** boundary, borderlands, bordering processes, mobilities, migration, trans-regional, Eurasia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Functions of the midbody ring in embryogenesis and tumorigenesis' under Seventh Framework.

assistant: **Concept**

There is ample evidence for important roles of cytokinesis in animal development besides ensuring faithful division of daughter cells. However, these additional functions and their mechanistic basis are not well understood. With the work proposed here we will elucidate roles of cytokinesis in differentiation and tumorigenesis. We will focus on the function of the midbody ring (MR), a protein-dense organelle that forms at the site of abscission during cytokinesis. This organelle forms only once during cell division and thus can only be inherited by one of the two daughter cells, creating an inherent asymmetry to cytokinesis. MRs have been implicated in sequestering stem-cell markers and as mediators of differentiation and pluripotency in vitro, the underlying molecular mechanisms and in vivo functions are not clear.We propose a multidisciplinary approach that combines microscopy, computational image analysis, and developmental genetics to analyze how asymmetric MR inheritance affects differentiation and tumorigenesis. We will transfer image analysis technology to the host institution that allows us to use Caenorhabditis elegans as a developmental model for automated cell tracking and fate mapping, to quantitatively analyze the function of MRs in development: We will investigate how asymmetric MR inheritance is regulated during C. elegans embryogenesis and tumor formation and how asymmetric MR distribution affects major differentiation decisions. C. elegans is ideally suited for these experiments since we know the entire embryonic cell lineage, all major differentiation decisions, can induce well-defined tumors, and have powerful genetic tools to manipulate development.We expect that the main results of our work will be of great general interest since they will for the fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The nature of dynamic protein - protein interactions' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content The alm of the research is to elucidate the nature of dynamic protein:protein interactions. Why are some complexes of proteins extremely static while others, in particular complexes of redox proteins, have very high turnover rates ? What are the roles in complex formation of the various non-covalent forces, such as electrostatic and hydrophobic forces and hydrogen bonds ? The project will analyze the structural and dynamic properties of a dynamic protein:protein complex in detail by a combination of kinetic measurements, site-directed mutagenesis and a new NMR approach. The latter is based on analysis of chemical shift changes caused by a) binding effects and b) intermolecular paramagnetic effects. This method is an excellent tool to obtain detailed information on the interaction sites of the two proteins and it has made it possible to determine the structure the complex of plastocyanin ( 10 kDa) and cytochrome (28 kDa), two redox proteins that have a crucial function in photosynthesis. In the project this new method will be exploited to study the effects on complex formation of the various non-covalent forces separately. Mutagenesis will be used to manipulate properties such as charge distribution and surface shape and polarity and the complexes of these mutants proteins will analyzed with NMR and by kinetic measurements. Furthermore, NMR will be used to study the dynamic properties of the proteins in the complex. Training content (objective, benefit and expected impact) Training objectives are twofold. First, to become fully competent as an experimental NMR spectroscopist, able to use multidimensional techniques for the study of proteins, and, second, to get familiar with the latest-developments in methods for site-directed mutagenesis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Content-Aware Wireless Networks: Fundamental Limits, Algorithms, and Architectures' (CARENET).

assistant: **Concept**

Wireless communication networks are the essential connectivity tissue of the modern digital age. Wireless data traffic is predicted to increase by almost three orders of magnitude in the next five years. It is unlikely that such increase can be tackled by an incremental “more-of-the-same” approach. This proposal stems from the observation that the killer application for wireless networks is on-demand access to Internet content. CARENET advocates a novel content-aware approach to wireless networks design that can provably solve the scalability problem of current systems, thus supporting the paradigmatic shift “from Gigabits per second for a few to Terabytes per month for all”.  CARENET’s vision is to serve an arbitrarily large number of users with bounded transmission resources (bandwidth, number of transmit antennas, and power). The fundamental question is: how can such a per-user throughput scalability be achieved in the presence of on-demand requests, for which users do not access simultaneously the same content? CARENET builds on a novel information theoretic formulation of content-aware networks and on several recent results in information theory, network coding, channel coding, and protocol design, stimulated by the PI’s recent work. Key elements of the proposed content-aware architectures are new caching strategies, where content is stored across the wireless network nodes. These strategies are supported by the ever-growing on-board memory of wireless devices and by the new features of the forthcoming 5G-like technology. Our thesis is that scalability is possible through the novel content-aware design, while it is information-theoretically impossible otherwise. Our overarching goal envisions the delivery of one Terabyte per month to each user at an affordable cost
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Accelerated Discovery Nanobody Platform' (ALADDIN) under Horizon Europe.

assistant: **Objectives**

Since the approval of the first monoclonal antibody (mAb) 30 years ago, therapeutic mAbs and Ab-derived molecules have come to dominate the biologics market. Currently, +100 Abs are in clinical use for different diseases, out of which +30 mAb target cancer. Despite the huge market potential, multiple and complex steps make the therapeutic Ab discovery process long, expensive, laborious, and inefficient.  These steps include target identification, animal immunization, Ab selection and engineering,  humanization and preclinical validation. All these are not integrated, costly, require large equipments and facilities, and are highly dependent on experimental animals (mostly mammals, including genetically modified mice), both for immunization and for preclinical validation of the therapeutic Ab candidates.ALADDIN project emerges to bring to the market a novel AcceLerAteD DIscovery Nanobody platform that will increase the efficiency of  therapeutic Ab discovery and preclinical validation for human cancer by: 1) integrating selection and in vivo affinity maturation of Abs in bacterial cells holding an universal library of single domain Abs (nanobodies, Nbs) that fully eliminates animal inmunization; 2) using in silico Artificial Intelligent (AI) tools for structure-based epitope mapping, AI-guided affinity maturation, and Nb humanization; 3) developing cost-effective miniaturized microfluidic-based devices for in vitro Ab selection from bacterial cultures; 4) accelerating Ab validation with a fast non-mammalian in vivo model for preclinical testing based on patient-derived tumor xenografts in zebrafish larvae; 5) impacting target and Ab validation with dynamic mathematical models to extract clinical and efficacy data of the Ab candidates.  These ambitious goals will be possib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Towards a model of human object recognition and attention'.

assistant: **Concept**

Research objectives and content This research proposal aims at understanding human object recognition within an inter-disciplinary framework, involving an interplay between connectionist models and experimental work. Current models of object recognition mostly lack the following properties: top-down influence on object recognition, explanation to a broad range of data, processing of real world images and consideration of attentional effects On object recognition. In previous work a Selective Attention Identification Model (SAIM) was developed which fulfils some of these critics. This research project intends to extend SAIM to SAIM2.0 to meet all of these requirements. The principle idea of SAIM2.0 is a minimisation of an energy function and a graph representation of objects which proved to be capable of processing real world images. The accompanying experiments and resulting explanations of SAIM2.0 will include attentional effects and the influence of knowledge on object recognition and grouping. Training content (obJective, benefit and expected impact) The proposed project will increase the already existing experience and skills in Computer Vision by the application of new methods, e.g. graph representation of objects. In addition it will lead to new experience and skills in Cognitive Psychology within an international collaboration with excellent scientists, such as Professor Humphreys and his colleagues of the Cognitive Science Research Centre at the University of Birmingham. Concluding, the training will lead to a very good foundation of an academic career in the field of Cognitive Science. Links with industry / industrial rele\ ulce (22) On the long term the results of this project can be applied in industrial area as well, e.g. vision based automated production.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Software architectures and embedded Systems' (SWARCES), addressing dissemination and exploitation.

assistant: **Impact**

The research proposed by this project will be carried out in the area of software architectures for telecommunication products and embedded systems based on components off-the-shelf (COTS).The main goals will be to develop:- New concepts of interworking and new architectural platforms that can be used efficiently in new generation products, decreasing development time and time-to-market, and increasing the overall quality of the product;- A database of new software components that will serve as the basis f or new component based architectures;- Develop and/or assess new integrated development tools that can be merged into the Siemens development process;- Assess and define improvements to the Siemens development process according to the new component based development concepts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Adsorbate Motors: Tricking Microscopic Reversibility on Surfaces' under Horizon Europe.

assistant: **Concept**

AMOS represents a ground-breaking approach to achieve uni-directional motion on well-defined surfaces, realize cooperative motor activity, control flow processes and transport cargo at the atomic scale. It is based on molecule-surface motors that overcome microscopic reversibility via controlled potential energy surface modulation with high potential impact in various fields. Light will be used to excite molecular motion, offering great versatility. Hence, the stimulus is given remotely to many molecules, while characterization is done at the single-molecule level, allowing for statistical analysis of trajectories in two dimensions.Different motor concepts will be used to controllably modulate the potential energy surfaces and address the key challenges in the field of molecular machines at surfaces. A variety of highly defined surfaces will be employed and novel adsorbate motors, molecules that achieve motor functionality only when joint together with a surface, will be studied. Advanced control of motion will be achieved by multiple motors. Complementary methods in microscopy, spectroscopy and interferometry with extremely high resolution in space, energy and time will be used – a key aspect of this project.AMOS addresses both fundamental research and technological aspects: it will yield elementary understanding of molecular motors with extremely high spatial (pm) and temporal (fs) resolution and investigate model systems for future applications with insight at the single-molecule level. It will explore collectivity to amplify motor activity by cooperative effects in precisely defined assemblies and will study these systems also under environmental conditions in view of steered flow processes at the solid-liquid interface. Specific chemical interaction will realize tr