RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Inferential processes in literal and figurative lexical interpretation: a comparative psycho-pragmatic study of healthy, autistic and schizophrenic subjects' (IPLI).

assistant: **Concept**

This project aims to build on current research in both experimental psycholinguistics and cognitive pragmatics with the objective of achieving a better understanding of the role of inference in lexical interpretation. Although research on lexical pragmatic s has been carried out both in the United States and Europe, the approach has been more experimentally oriented in American universities. I therefore intend to spend the first phase of the fellowship undertaking empirical research at Princeton, where I wil l be able to investigate theoretical questions that have arisen from my doctoral research. I would be particularly interested in familiarising myself with new research technologies from cognitive neuroscience, such as ERP and fMRI. In the second phase, I i ntend to return to UCL, which has been a centre for groundbreaking work on cognitive pragmatics over the last twenty years. There, I would like to apply the knowledge and skills gained in the first phase to an innovative project investigating lexical inter pretation in autistic and schizophrenic people. A comparative study between normal and cognitively dysfunctional participants should allow us to test theoretical models of lexical interpretation, as well as investigate the language comprehension deficits t hat these groups seem to have, in particular with figurative language. I believe that the opportunity of complementing my theoretical background by learning about experimental methods beyond those I used in my doctoral research would allow me to make a valuable contribution to the development of experimental pragmatics in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Oxygen sensing in cardiovascular progenitors cell fate decisions' (2007-2013).

assistant: **Concept**

Cardiogenesis is a complex process that involves different cell types that have to mature to form the final functional heart compartments. Isl1 cardiovascular progenitors label the “second heart field” and contribute to myocardial, smooth muscle and endothelial structures of the heart. These progenitors have been extensively studied but little is know about the extracellular signals mediating their cell fate decisions and biology. A more recent group of cardiovascular progenitors arising from the epicardium and labeled by the expression of Tbx18 or Wt1 have been reported to contribute to the coronary arterial tree, cardiac fibroblasts and atrial and ventricular cardiomyocytes. Embryonic hypoxia has been involved in cardiovascular system development, while the molecular mechanisms controlling the adaptation to low oxygen tensions during heart formation remain poorly understood. Thus, I aim to determine if changes in the oxygen supply could regulate early cardiovascular progenitor’s proliferation, migration or commitment towards specific differentiated cardiac lineages and evaluate the concept of hypoxia as a potential niche for cardiovascular progenitors. We aim to study cellular properties and mechanisms that might be influenced by hypoxia as cell metabolism, transcriptional regulation and modulation of morphogenic signaling pathways. Several reporter embryonic stem cell lines will be used as in vitro systems to trace and isolate discrete pools of cardiovascular progenitors after exposure to different oxygen tensions and recapitulate cardiac development in a dish. Additionally in vivo mouse models of conditional deletion of hypoxia pathway elements (HIFs, VHL, PHDs) in cardiovascular progenitors will be employed to confirm the in vitro data and to determine of the role
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Application of combined gene and cell therapy within an implantable therapeutic device for the treatment of severe hemophilia A' (HemAcure).

assistant: **Concept**

The main objective of the HemAcure project is to develop and refine the tools and technologies for a novel ex vivo prepared cell based therapy to treat the bleeding disease haemophilia A (caused by genetic deficiency in clotting factor VIII (FVIII)) that should ultimately lead to improved quality of life of the patients. The concept is a further development of our approach, established during the FP7 ReLiver project led by Medicyte. From the very beginning, we balance two important goals, maximizing the product’s efficacy and safety profile on one side and minimizing production cost on the other by enhancing the product’s manufacturability. HemAcure relates to the work program as we focus on the refinement of all steps and tools of our ex vivo gene therapy approach. These steps involve 1) isolation and culture of cells from patients’ blood, 2) manipulation of patient cells to repair its genetic defect by ex vivo introducing the correct genetic copy of FVIII (mutations in this gene lead to hemophilia A), 3) automation of cell expansion in a novel and passage-less scalable bioreactor, 4) continuously monitoring of cells during and after expansion with respect to their safety profile and functionality, 5) cell implantation into a worldwide unique medical device for targeted delivery of therapeutic Factor VIII and 6) proof-of-concept and safety studies in appropriate haemophilia A animal models. The aim of adapting the proof-of-concept to GMP requires a risk based approach, by means of a clear understanding of the whole process from design to production of the therapeutic cells and a systematic way to identify and prevent risks that are not acceptable for the patient. All steps will be designed and conducted according to European GMP-regulations to ensure that the product w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Determining the roles of the nuclear periphery in mammalian genome function' to be submitted under Seventh Framework.

assistant: **Abstract**

DNA sequence and epigenetic chromatin maps are important in understanding how genomes are regulated. However, these maps are linear and do not account for the three-dimensional context within which the genome functions in the cell. The spatial organisation of the genome in the nucleus is not random and is conserved in evolution, implying that it is under functional selection. This proposal aims to determine the functional significance of positioning specific genome regions at the edge of the nucleus in mammalian cells. The nuclear periphery has conventionally been considered as a zone of inactive chromatin and transcriptional repression. Several regulatory gene loci move away from the nuclear periphery as they are activated during differentiation. Novel approaches, developed by ourselves and others, that allow genomic regions to be relocated from the centre of the nucleus to the periphery, have directly shown that proximity to the nuclear edge can down-regulate human gene expression. We propose to dissect the pathways that mediate this spatially-defined transcriptional regulation, to determine what features make certain genes susceptible to it, to establish the functional consequences of preventing gene repositioning during differentiation, and to examine defects of the periphery found in premature ageing. A neglected hypothesis is that positioning of inactive chromatin against the nuclear periphery is a mechanism to minimize DNA damage on sequences in the nuclear centre. We will determine whether mutation rate is altered when loci are repositioned towards the nuclear periphery. By experimentally remodelling the spatial organisation of the genome, this proposal goes beyond the current descriptive phase of 3D nuclear organisation, into an understanding of its functional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Smart Gates for the ""Green"" Transistor""' (SMARTGATE) targeting Seventh Framework.

assistant: **Abstract**

Ultra-low voltage/power operation is expected to be an important requirement for future nanoelectronics allowing more dense and fast circuits on one hand and enabling the operation of energy efficient intelligent autonomous systems on the other. In present day devices quite a lot of power is consumed during switching since it requires a minimum bias of 60 mV on the gate to overcome a potential barrier and increase the transistor current by a decade, a process which is fundamentally limited by thermal Boltzmann statistics. We propose the development of novel negative capacitance “smart” gates with a positive feedback and internal amplification to overcome the “Boltzmann tyranny” and obtain steeper slope “green” transistors capable of operating at very low voltage. Metallic systems with a low density of states could provide the required dominant negative contributions to the capacitance due to strong carrier correlation effects. Such metallic systems made of 2D Dirac fermions with linear dispersion bands are supported in graphene and on the surface of the newly discovered topological insulators having the very interesting property that they offer a nearly zero density of states at the band crossing near the charge neutral point. We propose here the graphene and Bi2Se3-based topological insulators as the key components of the targeted “smart” gates. We aim at developing complex gate structures facing the challenges of growth of high purity and high crystalline quality graphene and Bi2Se3 thin films in combination with conventional dielectrics and metals on Si semiconductor in an effort to obtain the required properties and ensure their robust functionality at room temperature. Possible negative capacitance effects will be investigated in terms of generic capacitor electric
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Excited-State Dynamics of Molecular Solar Thermal Fuels' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Sustainable energy generation, conversion and storage are among the most challenging goals of this century. DynaMOST is concerned with MOlecular Solar Thermal (MOST) energy storage and release systems that can convert solar energy into chemical energy. Currently, very few MOST organic and organometallic systems are reported in the literature. Few simple yet elegant approaches are applied to improve their storage capacity and applicability. They rely on mostly trial-and-error variations of metals, alkyl chains, and photoactive units. Advance is hampered by the lack of mechanistic studies, particularly molecular-level information after light excitation. The ambitious goal of DynaMOST is to unravel the fundamental working principles of several MOST pushing ab initio dynamics simulations and quantum chemical methods beyond the state-of-the-art. Systems to study include dimeric transition metal complexes and large organic cyclophanes, which have demanding electronic structures and routine methodological techniques cannot be readily applied. Ultimately, DynaMOST is expected to deliver a rationale for designing new and efficient MOST systems. The experienced researcher will transfer knowledge in the transition metal chemistry, reaction mechanisms, and theoretical spectroscopy to the host group, and gain expertise in emerging quantum chemical methods and time-resolved chemical phenomena. A cross-sectoral workshop will increase the researcher's and host's networks. DynaMOST will provide the applicant with the basis to pursue an independent career, a unique and highly competitive research profile, excellent training, an increased scientific network and a comprehensive box of soft but essential skills, such as communication, management, dissemination and public engagement skills.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Xii international symposium on calcium binding proteins and calcium function in health and disease (CBPS 2001)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Support is seeked for a Syrnposium on Calciurn Binding Proteins and Calcium Functioning Health and Disease, scheduled to take place in Italy from 01/29 through 02/03 2002. It will be the XIIth in a series of symposia which have been organized indifferent countries every two years. The program has been put together by a Committee of which R. Rizzuto, T. Pozzan, and the applicant are members, and by an International Board. It will schedule 14 sessions (some in parallel),featuring 44 speakers (about half will be European). All areas of Ca2+ signalling research will be covered, from structural biology to pathology, stressing protein-linked aspects of the function of calcium. Two Round Tables, and two plenary lectures (the Ebashi^TMs lecture and an EMBO lecture) are also foreseen. About 250participants are expected, and 100-120 posters will be displayed. The majority of the participants (particularly junior people) will come from Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Microbial Interactions: Nitrifiers and their Partners in Complex Wastewater Microbiome' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Microbial interactions shape the structure, function, and resilience of microbiomes in wastewater treatment plants (WWTPs), directly impacting performance. Nitrifiers, as chemolithoautotrophs and primary producers, are particularly suitable for studying these interactions by assessing carbon flow through metabolite tracing with stable isotopes. This project aims to uncover the principles governing microbial interactions between nitrifiers and their partners through three work packages: identifying interaction partners, inferring their interactions by genome analysis, and verifying these interactions in situ. Potential partners will be identified combining co-occurrence network analyses, fluorescence-activated cell sorting of activated sludge microflocs containing nitrifiers, and amplicon sequencing to identify co-sorted microbes. Fluorescence in situ hybridization (FISH) will be used to confirm their spatial co-localization with nitrifiers. Next, deep long-read metagenomics will generate metagenome-assembled genomes (MAGs) of nitrifiers and their potential partners for genome analysis and metabolic modeling, identifying possible types of interactions. The hypothesized interactions will be verified using FISH and stable isotope probing (SIP) combined with chemical imaging such as mid-infrared photothermal (MIP) imaging and matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) to identify exchanged metabolites in situ. This project is among the first to integrate SIP, FISH, and chemical imaging (MIP and MALDI-MSI) to study microbe-microbe interactions directly in complex microbiomes at the single-cell or cell cluster level. The findings will provide new insights into interaction mechanisms within complex microbiome and help design strategies to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development of a unique means of detecting and proving illegal administration of recombinant somatotropin in dairy cows'.

assistant: **Innovation**

The ability to increase milk production in cow by bovine somatotropin (BST) was first demonstrated in 1930’s. The use of recombinant bovine somatotropin (rBST) in dairy cows has become a common practice in the Untied States (US) and many other countries as the commercial product became available in 1994. However the use and sale of rBST in the EU has never been approved and was banned in 1999 due to concerns on animal health and welfare, food safety and quality, and human health implication associated with the administration of rBST in dairy cows. Nevertheless, there are no direct methods available to date that are capable to detect rBST. The present proposal will, by the use of new technologies and a wide range of expertise, deliver a means of screening and confirming the presence of this unwanted growth promoter in milk. The collaboration within the project will bring together a university, a public institution and two private commercial diagnostic companies to produce novel solutions for monitoring the quality and safety of foods. The proposed research project will give an opportunity of Industry-Academia collaboration that will allow the transfer of high level scientific research into much needed commercial outputs. As a consequence, both academic and industrial partners as well as communities will all benefit, not only during the project but well beyond. The major research outcome will be the delivery of a rapid and simple screening test (dipstick and/or ELISA), a highly accurate and quantitative immuno-biosensor test, and a sensitive and specific chemical confirmatory test for rapid detection and unequivocal identification of the presence of rBST in milk. The formation of partnerships will strengthen the joint efforts to advance research in food safety and quality
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The achievement of an area of freedom, security and justice through the EU external relations', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This project concerns the way the European Union (EU) can build an area of freedom, security and justice by making use of its powers to enter into international agreements with third countries. The EU has recently acquired the competence to legislate in this area. Very recently, the European Council has put forward the idea that the EU internal action is not enough to build such an area. Challenges to the EU external borders such as illegal immigration and threatens to the EU internal security such as terrorist attacks and organised crime (money laundering, trafficking of human beings, drugs) require the EU to act as an international actor. This is why the EU has started to make use of a wide range of international agreements, affecting cross pillar policies, whose adoption involves various actors such as the Commission, the Council, Europol. The objective of this project is to identify possible legal problems that the European Institutions may face in concluding these agreements. More precisely, the following legal issues will be explored: a) to what extent international agreements are necessary as well as effective to build an area of freedom, security and justice; b) whether the EU is competent to enter into these agreements affecting an ever increasing number of cross pillar policies and to what extent Member States remain competent to conclude international agreements in areas affecting the EU internal security and the EU external borders; c) whether these agreements are coherent; d) whether these agreements create accountability problems, in particular as far as the Europol’s agreements are concerned.  This project is in line with the objectives of the Work Programme for experienced researcher since it is intended to expand the applicant’s competences in a new are