RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Regional Variation in Social Norms and Climate Change Action' (ClimaSoNo).

assistant: **Concept**

A growing body of research in the behavioral and social sciences highlight the potentially productive role of social norms in changing behavior towards more climate change action. To date, we have been neglected significant aspects: the large regional variation in behavior and beliefs, creating a gap in our understanding of i) how people perceive others’ behavior and attitudes in their region, ii) what kind of individual and regional factors explain the variation in social norms, and iii) how regional social norms causally effect climate-friendly behavior across economically, socially, and culturally diverse regions.To comprehensive study theses aspects represents the major thrust of ClimaSoNo beyond the current state-of-the art, providing new insights about the extent and nature of the regional heterogeneity in social norms. ClimaSoNo promises to collect and analyze a rich set of new scientific data from a comparative survey across 130 regions in 12 countries. The cross-regional survey includes a novel technique to accurately measure perceived social norms at the regional level (Task 1). The empirical analysis of ClimaSoNo will systematically explore the potential determinants of regional variation in social norms related to support for climate policies and climate-friendly behavior (Task 2). Cross-regional experiments will be carried out to test whether this novel technique of measuring social norms can predict climate change action across regions. In this way, ClimaSoNo will produce an experimentally validated ‘survey module’, measuring support for policies, climate-friendly behavior and perceived social norms (Task 3). Finally, ClimaSoNo capitalizes on cross-regional experiments to estimate the causal effect of different types of regional social norms on climate-fri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sequence sPecific ELImination of shiga-Toxin E. Coli' (SPELITEC), addressing dissemination and exploitation.

assistant: **Impact**

SPELITEC is the first treatment for Shiga toxin-producing E. coli (STEC) infections, which affects primary young children and can be fatal in 1-5% of the cases. Currently there is no validated safe treatment: hospitalized patients receive only symptomatic treatments consisting of rehydration coupled with transfusions and dialysis for haemolytic uremic complications. The SPELITEC program is designed to finalise preclinical and initiate clinical studies for elimination of STEC bacteria (Shiga-toxin producing E. coli) in paediatric populations with a dedicated product: EB003. EB003 selectively eliminates STEC bacteria early in the disease progression; it is not expected to exert any toxicity in humans or animals; it is a multivalent mix of different capsid variants allows to target the whole spectrum of clinically relevant strains and pre-empts the acquisition of resistance through mutation of bacterial receptors; it is administered orally by a liquid/gel which is patient-friendly and adapted to young children and it represents a cost-effective alternative to antibodies against Shiga toxins. Our technology is the only one allowing the specific elimination of STECs without toxin release and without disrupting microbiota and inducing antibiotic resistance. Eligo will complete early drug development, which should ensure market authorization given the orphan and unmet medical need nature of the indication, and plans to out-license the compound to an established pharma company that will launch the product on the market.The management team of Eligo has solid business and technical management experience in multinational companies and a very strong drug development background. During the Phase 2 project we will validate this new individualised therapeutic approach and mechanism of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Size Matters in Numerical Cognition' under Seventh Framework.

assistant: **Concept**

Numerical cognition is essential to many aspects of life and arithmetic abilities predict academic achievements better than reading. Acquiring a solid sense of numbers and being able to mentally manipulate numbers are at the heart of this ability. In recent years research has been marked by looking for the underlying mental operations, an effort to unravel the neural tissue that supports these operations, and identifying low-level deficits that underlie deficiencies in numerical cognition such as developmental dyscalculia. This accumulated body of results led to a widely accepted view of an innate, domain-specific, core numerical knowledge based on the ability to perceive and manipulate discrete quantities.However, several findings suggest that this wide agreement needs to be examined carefully; 1) similar to their sensitivity to discrete quantities (e.g., enumeration of objects), infants show sensitivity to non-countable continuous dimensions like perception of area (Brannon, 2006) and size (Lourenco, 2010). Mix et al. (2002) surveyed the literature on quantification in infancy and early childhood and suggested that the literature provides no clear-cut evidence that infants use numbers to perform quantitative tasks and that there is evidence that infants respond to amount of substance, rather than discrete numbers, in what had seemed to be numerical tasks. 2) Developmental trajectories similar to those with numbers have been shown to rely on domain-general rather than domain-specific abilities (Holloway, 2008). During development, language may provide a medium that bridges between core domain-specific systems (Munkholm, 2001; Platt, 2009; Spelke, 2003). Lastly, 3) numbers are intimately associated with non-countable dimensions (e.g., area, brightness). Accordingly, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cyber security 4.0: protecting the Industrial Internet Of Things' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Recent trends in industrial technology and the adaptation of Industrial Internet of Things (ΙIοΤ), has emerged by the convergence of Operations Technology (i.e., traditional hardware and software systems) and Information Technology (i.e., advanced computing, data aggregation/analysis, and ubiquitous communication systems). IIoT has great potential to enable significant advances in optimizing operations among large number of increasingly autonomous control systems and devices, and can have a profound impact on many industry domains, where smart factories and logistics are among most notable cases. However, a major barrier towards IIoT adoption lies in cybersecurity issues that makes it extremely difficult to harness its full potential: IIoT systems dramatically increase the attack surface (introducing new security threats due to newly connected devices and protocols, making them more vulnerable to interference), the disruption of process controls, the theft of intellectual property, the loss of corporate data, and the industrial espionage. C4IIoT will build and demonstrate a novel and unified IIoT cybersecurity framework for malicious and anomalous behavior anticipation, detection, mitigation, and end-user informing. The framework provides a holistic and disruptive security-enabling solution for minimizing attack surfaces in IIoT systems, by exploiting i) emerging security software and hardware protection mechanisms; ii) state of the art machine and deep learning and privacy-aware analytics; iii) novel encrypted network flow analysis; iv) secure-by-design IIoT device fabrication; and v) blockchain technologies, to provide a viable scheme for enabling security and accountability, preserving privacy, enabling reliability and assuring trustworthiness within IIoT application
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dendritic cells as natural adjuvants for novel vaccine technologies', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The immune system evolved to respond to pathogens, whilst limiting self-tissue damage. Unique antigens presenting cells, called dendritic cells (DC) initiate immune responses upon encounter with foreign microorganisms or inflammatory stimuli trigger innate immune responses that represent the first line of defence against invading pathogens. Subsequently, activated DC prime antigen-specific immune responses that clear the infections and give rise to immunological memory. This proposal is to develop in sito DC targeting for use as vaccines in infectious diseases and cancer. We will define improved reagents and protocols for antigen delivery and targeting, to improve antigen processing and presentation by DC for use in vaccine technology. A comparison will be made on peptides, proteins, RNA, DNA and antigen modifications that allow presentation via MHC molecules. Recombinant bacteria and viral vectors are most suitable for the transduction of etherologous model antigens into DC.Different approaches will be undertaken to develop microbial vectors delivering antigens to DC with the highest efficiency for presentation via MHC class I and II molecules. Preliminary results show that DC loaded with recombinant bacteria and injected in vivo are capable of protecting mice for tumour challenge. Recombinant viruses, some encoding poliepitopes, will also be used as vectors to target DC. CTL primed by virus infected DC have cytolytic activity and can protect mice from tumour challenge. Viral vectors will also be generated to exploit the promoter regions of DC specific C-type lectins such as DC-SIGN to target and deliver model and tumour antigens to DC, and these will be cloned in mouse and humans and used to drive the expression of model and tumour antigens. Such approaches will be te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Control of cell division in Sulfolobus acidocaldarius' (CCDSA) under Horizon 2020.

assistant: **Objectives**

Archaea and eukaryotes share conserved regulators such as ESCRTIII proteins that are involved in fundamental aspects of eukaryotic cell division, a finding that assumes particular importance in the context of widely accepted models for the evolution of eukaryotes from an ancestral archaeal host. Yet the mechanisms by which archaea regulate cell division- in the absence of nuclei, organelles and a rigid cell wall- are poorly understood. The research programme proposed here aims to fill this gap in our understanding by investigating the control and coordination of cell division in the model crenarchaeote Sulfolobus acidocaldarius. We will use super-resolution imaging in combination with cell sorting and electron cryotomography to characterize cell cycle progression in Sulfolobus at unprecedented resolution. We will leverage a novel in-house high-temperature live imaging platform and proteins labeled with thermostable GFP to dissect the molecular coupling between the key processes of chromosome segregation, membrane invagination, and abscission. Further, we will use forward genetics, whole-genome sequencing and comparative genomics to identify novel cell division regulators that are conserved in eukaryotes. We expect this detailed characterization of cell division in cells without organelles or a nucleus to have broad implications for our understanding of the origins of the more elaborate mechanisms found in extant eukaryotes. Moreover, in the future we expect the knowledge gained and interdisciplinary approaches developed here to be applicable for the study of Loki, the recently identified closest archaeal relative of eukaryotes, and for furthering the industrial utility of hyperthermophilic archaea.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Enhancement of research capabilities on multi-functional Nanocomposites for advanced fuel cell Technology through EU-Turkish-China Cooperation'.

assistant: **Objectives**

The project aims to enhance research capacities on nanotechnology, multi-functional materials and advanced applications. Material innovations and advances are created on the multi-functional nano-composites concerning superionic conduction; hybrid H+/O2-conduction; nano-composite ionics; and next generation fuel cell technology.The project objectives are:- To extend the existing Turkish cooperation and Sino-Swedish IT/LTSOFC (intermediate and low temperature solid oxide fuel cell) network with prominent research institutions in EU; to network research cooperation and joint activities; to develop centres? infrastructure and research or innovation strategies.- exchanging and sharing personnel, information, resources and research methodologies.- training researchers and organizing the seminars, organize research plan and explore new research subjects on the related areas; senior researchers' visits to strength and develop research links with EU institutions, improve research methodologies and skills.- Various joint PhD and Postdoctoral programs build highly qualified, well-trained research team and bring new skills together; to expose centre fellows/scientists and students from different cultural and scientific background; through various means of supports to increase women students/scientists in the centre.- enhancing its research infrastructures, thus, raising the capabilities and standards of the centre to EU level, mobilize the existing human and material resources in the centre, promoting the trans-tech. and research achievements to industry and to establish new ways of production research in cooperation with China and Turkey.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'TURBULENCE, PEBBLES AND PLANETESIMALS : THE ORIGIN OF MINOR BODIES IN THE SOLAR SYSTEM', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The Minor Bodies of the Solar System, Asteroids, Trojans, Comets and Kuiper Belt Objects are left over planetary building bricks called planetesimals once abundant in the solar nebula. Via collisions and accretion of large grains, aka Pebbles, they grew into planets. The efficiency of Planetesimals formation via a gravitational collapse of Pebble clouds and the characteristics of the forming planetesimals are determined by the size distribution and local concentration of the largest grains, both being regulated by gas turbulence. But turbulence itself is dependent on the abundance of small grains, by regulating the ionisation level and the radiative cooling process.In this project we will develop radically new types of numerical experiments of three stages of planetesimal formation, with the goal of a self-consistent turbulence and pebble size distribution:1. Development of tools to measure the transport, diffusion, and collisions of dust grains for arbitrary MHD or Radiation Hydro disk simulations to derive via an Coagulation Code and Machine Learning Technique a consistent particle size distribution for consistent opacities and ionisation rates to feed back into the turbulence simulation. 2. Implementation of a tree-solver for the gravitational attraction among pebbles in self-consistent turbulence simulations to identify the properties of pebble clouds that can undergo gravitational collapse. 3. Integration of an implicit solver for our Lagrangian Particle scheme to model the collapse of pebble clouds, while not only deriving a mass function and multiplicity, but with a model for elasticity and porosity analyse the spin, shape, and compression for the forming planetesimals, comets and asteroids.In close collaboration with our scientific community we will calibrate ou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The African Neolithic: A genetic perspective'.

assistant: **Innovation**

The spread of farming practices in various parts of the world had a marked influence on how humans live today and how we are distributed around the globe. Around 10,000 years ago, warmer conditions lead to population increases, coinciding with the invention of farming in several places around the world. Archaeological evidence attest to the spread of these practices to neighboring regions. In many cases this lead to whole continents being converted from hunter-gatherer to farming societies. It is however difficult to see from archaeological records if only the farming culture spread to other places or whether the farming people themselves migrated. Investigating patterns of genetic variation for farming populations and for remaining hunter-gatherer groups can help to resolve questions on population movements co-occurring with the spread of farming practices. It can further shed light on the routes of migration and dates when migrants arrived.The spread of farming to Europe has been thoroughly investigated in the fields of archaeology, linguistics and genetics, while on other continents these events have been less investigated. In Africa, mainly linguistic and archaeological studies have attempted to elucidate the spread of farming and herding practices. I propose to investigate the movement of farmer and pastoral groups in Africa, by typing densely spaced genome-wide variant positions in a large number of African populations. The data will be used to infer how farming and pastoralism was introduced to various regions, where the incoming people originated from and when these (potential) population movements occurred. Through this study, the Holocene history of Africa will be revealed and placed into a global context of migration, mobility and cultural transitions. Additi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'X-ray Multiple Ionization of Impulsively Aligned Molecules' (X-MIAM).

assistant: **Concept**

High-energy and ultrafast soft/hard X-ray photon beams open new fields in Science with major applications to Biology, Chemistry and Physics. Indeed, a couple of X-ray free-electron lasers (XFEL) are under construction worldwide with the highly exciting objective to perform atomic resolution, 3D movies, by taking a sequence of femtosecond snapshots, of biological molecules such as viruses, proteins etc. Because of the need to capture an image on a single, femtosecond shot, the number of photons per shot should exceed 1013 and thus the intensity (≥ 1018 Wcm-2) on sample will far surpass any intensity ever achieved at short wavelength. Thus, the crucial question “will the structure of molecules be modified during the snapshot?” arises and has not been solved so far by lack of appropriate experiments. Non-linear effects may dominate and we are aware that we should control/understand theses processes. In 2009, the LCLS x-ray Free-electron laser at Stanford (USA) will be the first hard X-ray Free Electron Laser (FEL) in operation. The next one will be the XFEL in Hambourg in 2012. Our objective is to use the unique access to the Stanford XFEL through to study the interaction of ultra-intense X-ray FEL pulse with an aligned molecular ensemble. Complementary expertises in pump probe soft-X-ray and infrared light scheme in molecular science and theoretical support is provided through an international collaboration. This proposal requires the ultra-short duration to probe transiently aligned molecules and it needs the very high X-ray brightness to drive multiple ionization. We will distinguish between the linear (simple photo-absorption) and non linear response (two photon absorption) of the molecular system. We propose to use (double) core hole decay as a means of molecular orbi