RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Decoding animal genomes into cell types' (Genome2Cells) targeting Horizon Europe.

assistant: **Abstract**

The genome of an animal encodes a large set of regulatory programs that give rise to the thousands of cell types that make up its tissues and organs. Despite recent progress in single-cell omics, our knowledge about the regulatory programs that control the establishment and maintenance of cell type identity remains limited, and methods are lacking to infer regulatory programs directly from the genome sequence. In this project, which lies at the interface between the genome and single-cell atlases, we ask how the genome sequence translates into cell types. We start with Drosophila as model organism. Its compactness allows sampling of all its cell types and developmental trajectories from egg to adult, using whole-organism single-cell multi-omics, thus capturing the spectrum of activation states that emerge from the regulatory genome. Deep learning models will be trained on regulatory sequences to predict and explain gene regulatory networks (GRN) and GRN transitions between cell states, encoded by enhancers, promoters, transcription factors (TF), effector genes, and feedback loops. Based on a better mechanistic understanding, we will translate this framework to other animals, including octopus, birds, and mammals, and ask how regulatory programs evolve, with a focus on neuronal diversity in the brain. Using new algorithms for cross-species deep learning and combinatorial optimization, we will study how combinations of expressed TFs co-evolve with genomic enhancer logic. We are unique in our approach because we will develop and use new technological assays, deep learning, and massively parallel reporter assays, and combine these with perturbation experiments and synthetic biology to test our hypotheses. After iteratively improving our regulatory models, we ultimately aim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CalSAF: Calorimetry for Sustainable Aviation Fuels – High-resolution techniques to advance hydrothermal liquefaction and hydrotreating, turning waste into biofuels' (CalSAF).

assistant: **Concept**

Wet waste and long-distance travel are unavoidable consequences of wealthier societies; unfortunately, they both contribute to climate change. Hydrothermal liquefaction (HTL) and biocrude hydrotreating (HT) can convert wet wastes into sustainable aviation fuels (SAF), but for this to become a reality, some pressing challenges need to be addressed. CalSAF is Dr. Matteo Pecchi’s career development program, designed to develop differential scanning calorimetry (DSC) methods that can provide high-resolution information on the HTL and HT process development in-situ, at a fraction of the cost of traditional methods using batch reactors and chemical analyses.Dr. Pecchi’s training is supported by an international collaboration of world-leading universities and experts in the hydrothermal field, leveraging their cutting-edge experience and equipment. This collaboration aims to facilitate his transition into an independent researcher and expert in thermochemical processes for waste valorisation, which is central to his long-term career goals.If successful, CalSAF will uncover new insights into the mechanisms and kinetics of HTL and HT, addressing key challenges that currently hinder industrial SAF production from wet waste. These challenges include the high costs and time associated with HTL screening campaigns and the lack of data for effective control to prevent clogging in HT reactors. The impact on both waste management and fuel production sectors will generate significant environmental, social, and economic benefits, including reducing emissions, decreasing pollution and health risks, and opening a potentially multi-million-euro market.


**Keywords:** Hydrothermal liquefaction, hydrotreating, sewage sludge, waste recovery, kinetics, chemical mechanism, differential scanning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Color and texture matching for wood panel in furniture industry' (SCANMATCH), addressing dissemination and exploitation.

assistant: **Impact**

The purpose of SCANMATCH project is to develop a scanner for qualitative analysis of wood panels in order to match them before assembling pieces of furniture. Up to now, systems for wood analysis are dedicated to solid wood in order to detect defects before sawing or grading. Nowadays these systems don't take into account aesthetic parameters adapted to furniture industry requirements. Usually structural defects (Knots, cracks, wanes, ...) are eliminated before panelling, so the remaining problem to solve is to globally appreciate the look of wood pieces. For furniture manufacturers, a perfect matching is very important because it concerns directly the aspect of the final product. Aesthetic aspect of a piece of furniture is one of the main criteria for customers. To be able to solve the problem, it is important to take into account two characteristics which are not usually analysed by scanners: Colour and TextureNowadays colour cameras can get images from which colour and texture can be analyse, on the contrary image processing software are not yet able to give an appreciation of these characteristics. Main difficulties come from wood heterogeneity: colour and texture are rarely regular, so that even for a man it is difficult to make always an reliable decision. In addition, the current sorting software are not able to carry out complex matching as human operators can do. So it is necessary to develop a specialised matching software with which the user can parameterise its requirements for texture and colour. The advantage of this type of scanner will be to classify wood panels in order to obtain pieces of furniture with a regular and good looking aspect. This is very important because up to now, we mean with a manual matching, it was only after assembling that problems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Defining how environmental factors influence downstream effects of immune-mediated disease risk-SNPs'.

assistant: **Objectives**

In the last few years genome-wide association studies have revealed thousands of genetic variants associated to immune-mediated diseases, such as rheumatoid arthritis and Crohn's disease. Although it is evident that non-genetic factors can also trigger these diseases, presumably by interacting with the risk SNPs, we do not know what these factors are or how they affect risk-SNPs.I hypothesize that environmental factors that increase disease risk also mediate the downstream molecular effects of disease-associated genetic variants. Since I am able to identify the downstream molecular effects of many risk-SNPs, and can identify molecular pathways regulated by specific exogenous factors like viral, bacterial or fungal stimuli, I now propose to combine these two approaches into a new analytical framework that will allow me to identify some of the exogenous factors that interact with risk-SNPs and together predispose to immune-mediated diseases.My aim is to determine how exogenous triggers alter molecular pathways that are critical in immune-mediated diseases. For this we will generate single-cell RNA-seq data on white blood cells from 100 individuals (~1,000 cells per person) and conduct expression QTL analyses. We will then use this information to identify exogenous risk factors for immune-mediated diseases by re-analysing public RNA-seq data from >20,000 samples generated in the presence and absence of different (disease) stimuli.This project is given direction by three developments by my research group: (1) our collection and integration of large functional genomics datasets, (2) our ability to develop computational frameworks for identifying the downstream consequences of SNPs using such datasets, and (3) my methodology to identify context-specific eQTLs.This research wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Solar-assisted natural ventilation with heat pipe heat recovery' (1994-1998).

assistant: **Concept**

Objectives The project aims to develop and evaluate a novel heat pipe heat recovery system for use in naturally-ventilated buildings using passive stack ventilation. Solar/wind energy solutions to assist the ventilation flows are also included in the development work. Special attention will be paid to the total energy efficiency of the system together with indoor air quality. Technical Approach Natural ventilation is being applied to an increasing number of new buildings across Europe to minimize reliance on mechanical ventilation and so reduce emission of greenhouse gases. However, virtually all passive solar ventilation (PSV) systems are designed and constructed without incorporating heat recovery, leading to wasteful heat loss. The heat loss can effectively be decreased using heat recovery. However, the heat recovery reduces the stack effect driving the air flows in the ventilation system. To avoid too small air flows and possible indoor air quality problems, some flow assisting solutions must be added to the system. The assistance of flows will be done using solar/wind energy devices. The project is broken down into four work packages in the following way: WP1: Design and construction of the heat pipe heat recovery system, WP2: Design and construction of the ventilation flow assisting and controlling solutions, WP3: Optimisation of the whole system, WP4: Testing and evaluating of the system performance. Expected Achievements and Exploitation The project is expected to produce a pilot ventilation system having the features mentioned above and monitored results of the performance of the system when installed in a building. The system developed is of prime interest to ventilation companies, manufacturers of heat pipe recovery systems and solar/wind energy systems. It c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Mechanisms of ochratoxin a induced carcinogenicity as a basis for an improved risk assessment'.

assistant: **Innovation**

Ochratoxin A is a mycotoxin which contaminates a variety of human food. In experimental animals, ochratoxin A is nephrotoxic and induces tumors, in the kidney, but also in other organs of rodents. In humans, exposure to high levels of ochratoxin An in diet has been linked with chronic renal disease (Balkan endemic nephropathy, interstitial nephritis) and an increased incidence of urinary tract tumours. The proposal includes novel approaches to study mechanisms of ochratoxin A tumorigenicity to kidney and combines studies in vivo and in relevant in vitro models to investigate the occurrence and nature of damage to DNA and other macromolecules induced by ochratoxin A and its metabolites. These studies include sophisticated analytical chemistry and applications of molecular biology to a toxicological problem. After completion, an improved understanding of mechanisms resulting in DNA-damage by ochratoxin A will be obtained.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of rehabilitation technologies and approaches for multipressured degraded waters and the integration of their impact on river basin management' (AQUAREHAB), addressing dissemination and exploitation.

assistant: **Impact**

Within the AQUAREHAB project, different innovative rehabilitation technologies for soil, groundwater and surface water will be developed to cope with a number of hazardous (nitrates, pesticides, chlorinated and aromatic compounds, mixed pollutions,…) within heavily degraded water systems. The technologies are activated riparian zones/wetlands;  smart biomass containing carriers for treatment of water in open trenches; in-situ technologies to restore degraded surface water by inhibiting influx of pollutants from groundwater to surface water;  multifunctional permeable barriers and injectable Fe-based particles for rehabilitation of groundwater. Methods will be developed to determine the (long-term) impact of the innovative rehabilitation technologies on the reduction of the influx of these priority pollutants towards the receptor. A connection between the innovative technologies and river basin management will be worked out.  In a first stage of the project, the technologies and integration of their impact in river basin management will be developed in three different river basins (Denmark, Israel, Belgium). In a second stage, the generic approaches will be extrapolated to one or two more river basins.  One of the major outcomes of the project will be a generic river basin management tool that integrates multiple measures with ecological and economic impact assessments of the whole water system. The research in the project is focussed on innovative rehabilitation strategies to reduce priority pollutants in the water system whereas the generic management tool will include other measures related to flood protection, water scarcity and ecosystem health, The project will aid in underpinning river basin management plans being developed in EU Member States, and will demonstrat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tracking memory during sleep: understanding how re-play of complex information affects memory and mental health' to be submitted under Horizon Europe.

assistant: **Abstract**

The field studying the processing of memory during sleep has been gaining attention lately, leading to some significant progress in our understanding. However, the challenge now is to translate these in-sights into practical psychotherapeutic options for mental disorders that are traditionally hard to treat. Our research aims to address this gap by using innovative behavioral paradigms and advanced neuro-scientific methods to tap into the therapeutic potential of sleep.Rather than treating clinical utility as an afterthought, we have integrated it into the core of our proposal (work package D). During sleep, memories undergo a replay process that strengthens and trans-forms them. We want to provide direct evidence of this phenomenon in humans, building on studies in rodents and humans. Our approach involves creating a reliable procedure to track memory reprocessing using a cutting-edge MEG scanner with machine learning to identify replay events during sleep. We'll also explore how complex memories unfold over several weeks and use a novel behavior-al paradigm to generalize how complex memories are consolidated. This will allow us to examine how depression can disrupt this process, offering new possibilities for therapy.While developing these methods presents challenges and the outcomes are uncertain, we believe the potential benefits make it worthwhile. Success in our project could pave the way for future efforts to manipulate memory replay during sleep—an exciting possibility. The project provides a vital step to later establishing a closed-loop approach that both measures and responds to replay, e.g., by acoustic or electrical stimulation techniques. We hope in the end to pioneer techniques that can support therapy for prevalent mental health challenges like depressio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'LEFT HANDED MATERIALS BASED ON MAGNETIC NANOSTRUCTURES'.

assistant: **Concept**

The project aims at development of novel magnetic nanostructures showing the effect of a negative index of refraction (e<0 and µ<0), named as left handed materials, using low cost and environmentally friendly processes such as sputtering and chemical-self assembly. The main objective of this proposal is through a trial and error process, but also based on existing theoretical models, to explore the possibility to demonstrate the reverse Snell's law behaviour of these nanostructures. In addition to structural and magnetic properties studies the frequency dependence of e and in the GHz regime will be studied using a Network analyser (S-parameter measurements). The positive results of such a coordinated effort by two specialized teams, will be the basis for a more extended effort in EC with positive impact in a number of industries, especially in telecommunications.OBJECTIVESThe aim of the project is to develop new nanomagnetic materials suitable for demonstration of left handed properties namely, negative dielectric constant and negative magnetic permeability in the frequency range of 1-40 GHz. This goal sets the following specific objectives: a) form magnetic nanorod structures which look similar to the metallic structures already studied b) prepare metallic-magnetic particles embedded in a dielectric matrix with e<0 in a narrow frequency range c) form magnetic needle-shaped nanoparticles and disperse them in a dielectric matrix (e<0), and d) characterize them with respect to microstructural, magnetic and more important the frequency dependence of their effective dielectric constant and magnetic permeability , with the projection that at some frequency close to plasma frequency- range the values will be negative.DESCRIPTION OF WORKThe work is separated into two main part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Consortium for Communicating Stem Cell Research' in the context of a Horizon 2020 call.

assistant: **Objectives**

The European Consortium for Communicating Stem Cell Research (EuroStemCell) unites 33 partner institutions, that collectively represent >400 stem cell research groupings across Europe. Our common goal is to provide trusted high quality information on stem cells accessible to citizens and stakeholders across Europe, through support and further development of the multi-lingual European Stem Cell Information Portal www.eurostemcell.org. To achieve our aims, EuroStemCell will adopt the highly structured system for coordinated information management established by the FP7 Coordination and Support Action (CSA) also called EuroStemCell. From this, we will implement an ambitious programme of online and direct stakeholder engagement with stem cell research and regenerative medicine, aimed at European citizens at all educational levels. This will include provision of resources tailored specifically for decision-making on stem cell-related questions and an extensive programme of dissemination and capacity building in science communications and public engagement. The proposed work centres on an information hub team, which will link to all project partners and to stakeholders in the stem cell and regenerative medicine arenas and wider society, working with these groupings to implement the project. All outputs will be delivered in 6 European languages, to ensure broad accessibility, and will be rigorously evaluated against measurable objectives throughout the project duration. The proposed consortium comprises leading stem cell labs across Europe, including new member states, together with experts in ethical and societal concerns and evaluating clinical outcomes. It thus provides unparalleled European expertise across the fields of stem cell biology and regenerative medicine and is u