RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modeling first-order Mott transitions' in the context of a Horizon 2020 call.

assistant: **Objectives**

Mott insulators are “unsuccessful metals”, where conduction is impeded by strong Coulomb repulsion. Their use in microelectronics started to be seriously considered in the 1990s, when first reports of field-effect switches appeared. These attempts were motivated by the expectation that the dielectric breakdown in Mott insulators could suddenly release all formerly localized carriers, a significant potential for nanometer scaling. Over the very last years striking experimental data on narrow-gap Mott insulators have finally materialized that expectation disclosing an unprecedented scenario where the metal phase actually stabilized was only metastable at equilibrium, which foreshadows exciting potential applications. These new data call for an urgent theoretical understanding so far missing. In fact, the conventional portrait of Mott insulators has overlooked that Mott transitions are mostly 1st order, implying an extended insulator-metal coexistence. As a result, bias or light may nucleate long-lived metastable metal droplets within the stable insulator, as indeed seen in experiments. The unexpected 1st order nature of dielectric breakdown in Mott insulators and its poorly explored but important conceptual and practical consequences are the scope of my theoretical project. I will model known Mott insulators identifying the variety of mechanisms (Coulomb, lattice distortions) that support and boost the 1st order character of the Mott transition. I will model and study insulator-metal coexistence and associated novel phenomena such as those related to nucleation and wetting at the interface, including possible unexplored role of quantum fluctuations. I will then simulate in model calculations the spatially inhomogeneous dynamics and non-equilibrium pathways across the 1st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Efficient filtering of metallic impurities in food processing' (Magnesys).

assistant: **Innovation**

In food processing like in the case of flour mills but also other powder type materials, the contamination by metallic impurities is a problem. Today`s magnetic filters do not satisfying in term of efficiency and cleaning costs. Bullet magnets that are state-of-art of the filter technology are expensive to operate because of the high electric consumption. MagneSys developed and tested HGF , a novel patent pending magnetic filter for food processing that allows the continuous filtering-out of iron magnetic particles from various solid foods in dry powder form such as flour for example.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Prediction of the erosion of cliffed terrains (PROTECT)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The erosion of coastal cliffs is inevitable. The cliff collapses are a hazard, a problem for coastal land use planners and limit the use of the coastline as an amenity. PROTECT will research techniques that will identify cliffs that are approaching a state of imminent collapse and allow accurate predictions to be made of the timing of the collapse. One technique will attempt to remotely measure changes in tension within the fracture network near a cliff face, whilst others will monitor acoustic crack emissions generated during fracturing. If successful, the results will provide both long term and short-term alerts of cliff instability. The techniques will be developed at cliff research sites where control data on the physical properties of the cliffs are available. Outputs will be the monitoring techniques, recommendations for their implementation by coastal managers and increased understanding of cliff collapse parameters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of a Functionalised Biomaterial Scaffold to Treat Multiple Sclerosis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Multiple sclerosis (MS) is a chronic inflammatory immune-mediated demyelinating disease of the central nervous system (CNS), which affects 700,000 people in Europe, with total annual healthcare costs of over €27.3 billion. Current available treatments for progressive MS have modest effects on relapse symptoms but do not modify disease progression. Critically there are currently no licensed disease-modifying treatments for progressive MS. My strategy will represent a disease modifying treatment for progressive MS. I will fabricate and optimize the loading and release profile of the an anti-TNFR1 antibody from ROS-responsive collagen spheres, I will assess the biocompatibility, bioactivity, and neuroprotective effect of the anti-TNFR1 antibody functionalized ROS-responsive collagen hollow spheres in organotypic cerebral slice cultures. I will evaluate the efficacy of the anti-TNFR1 multifunctional spheres against chronic neurodegenerative pathology in a preclinical model of progressive MS that mimics the pathology seen in progressive MS patients. Progress to completion will be reviewed by a Research and Professional Development Plan which will provide both discipline-specific and complementary technical training and generic and complementary transferable skills training (intellectual property, leadership skills, motivation skills, communication skills, regulatory affairs, clinical trial design, reimbursement strategies, medical device evaluation and regulatory affairs). I will benefit from Prof Pandit’s and Dr John O’Dea’s (Crospon Limited) (inter-sectorial secondment) international collaborative network in the field of neurodegenerative diseases. This training will facilitate me to achieve my future career goals of achieving a position of professional maturity, diversity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nonequilibrium Quantum Transport, Probes and Simulations' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Nonequilibrium Quantum Transport, Probes and Simulations is an ambitious research proposal aimed at designing both theoretical methods and practical schemes to describe and control nonequilibrium many-body quantum systems. With a combination open-quantum-systems, tensor networks and non-equilibrium Green’s functions NQTPS will develop methods to model nonequilibrium quantum systems with applications to quantum transport, weakly disturbing probes and Simulations. Specifically we aim to (1) Control transport between many-body systems designing small quantum rectifiers that operate at their interface. The rectifier is an asymmetrical and non-linear structure that breaks reciprocity. This novel development will be done beyond the main-stream phenomenological approach to dissipative systems which fails to give correct results specially in the presence of structured baths.(2) Extend scalable Matrix-Product-State techniques to model 1-D many-body open systems beyond the local Lindblad approach. Once a method capable of describing open-many-body-systems is stablished we will use it to characterize emergent transport (ballistic, diffusive, anomalous, insulating).(3) Design weak-coupling schemes to small probes for measuring fine features of complex quantum systems. We will propose probing of spacial and time correlations while leaving the many-body system almost unperturbed.(4) Model the dynamics of two-dimensional driven dissipative systems, focussing on adiabatic evolution subject to external noise. These models describe the fundamental structure on which companies are investing on for prototype quantum simulators and computers. We aim to address driven dissipative phase transitions and analyze their impact for adiabatic quantum simulation and quantum annealers. We will develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovative digital twin concept of complex microstructure evolution in multi-component materials' under Horizon Europe.

assistant: **Concept**

Tailoring the microstructural features in metal additive manufacturing (AM) products is still a great challenge, limiting the design flexibility and full exploitation of the technique. The aim of muTWIN is to implement and validate an innovative digital twin concept of microstructure evolution in technical alloys. The new concept allows for fast and accurate computation of local microstructures in AM parts as a function of local composition and temperature history. When integrated in thermal and mechanical Finite Element (FE) approaches it will enable realistic predictions of properties, performance and reliability of the printed parts. Moreover,  it allows for fast and high-dimensional computational ‘search’ through the huge design space accessible with AM, to find the compositions and processing parameters resulting in the most superior properties. With muTWIN, AM companies can drastically reduce the time-to-market and experimentation cost for new products. This brings new opportunities to design structurally and functionally graded materials and discover new alloy compositions and processing routes and will drive innovation in many other areas as well, such as medical applications, aerospace, construction and energy. The patentability of this idea and interest from industrial partners will be examined and a strategic plan for valorisation and possibly commercialisation of the product will be developed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Response of Ecosystem Assembly and Function to Climate Change:  A multidisciplinary approach to understand community response to climate change in coastal rocky ecosystems'.

assistant: **Objectives**

Ocean ecosystems are among those most at risk from global climate change.  Coastal water chemistry, and carbon chemistry in particular, is changing at a greater rate than ever before, and will drive coastal pH lower than has been experienced by any modern organism.  Concurrently, on-going increases in seawater temperature will affect physiological processes at the organismal scale and cause shifts in species ranges at the macroecological scale.  It is therefore important to assess the potential for biological response to such changes, on both the species and community levels.  The proposed work will target algal-grazer interactions in rocky coastal marine ecosystems.  Algal-grazer interactions are known to be of particular importance in the structuring of these communities and maintenance of local biodiversity.  Emphasis will be placed on the role of chemical defence compounds produced by algae as mediators of these interactions, and the role that environmental change will play through chemical and physical changes to seawater as possible drivers to change community assembly and function via algal-grazer processes.  Research aims include 1) natural observation and measurements at a variety of natural field sites, 2) field experiments, 3) laboratory experiments, and 4) synthesis of these data through ecosystem-scale models used to predict community function and biodiversity.  This proposal integrates techniques from ecology, phycology, physiology, and both inorganic and organic biogeochemistry to address ecological consequences of climate change from the individual to community scales.  These results will be important for socio-economic valuation of coastal ecosystems across Europe and globally.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mimimally invasive retrograde targeting of aCAR lentiviral vector to non-human primate motor neurons' (RTLVNHP).

assistant: **Innovation**

Lentiviral vectors pseudotyped with the rabies-G envelope have been used for the delivery of therapeutic transgenes via the peripheral intamuscular route, increasing lifespan and reducing neuromuscular deficits in mouse models of both amyotrophic lateral sclerosis and spinal muscular atrophy.  Despite these successes clinical translation of gene therapy for ALS with these and other vectors with retrograde transport such as AAV2 has been hampered as a result of limitations experienced with gene transfer in non-human primates (NHPs).  In order to overcome these limitations, and to design a safe, efficient and a minimally invasive therapeutic strategy, we have developed as part of the ERC Advanced investigator’s grant: IRLVGTMND, a novel new generation of surface engineered lentiviral vectors with tropism to  motor neurons (MNs) via the neuromuscular junction (NMJ). These vectors are targeted with antibodies against NMJ presynaptic terminal receptors, such as the CAR (coxsackievirus and adenovirus receptor). We found that these vectors can recognise, bind and enter target cells with high specificity determined by the antibody incorporated on their surface. They have specificity for MNs and have retrograde transport as demonstrated in vitro in compartmentalised primary motor cultures and in vivo upon intramuscular (i.m.) delivery  in leg muscles leading to transduction of lumbar spinal cord MNs. All data to date indicate that the targeted lentiviral vectors we have constructed have superior transduction and specificity for MNs than previously used lentiviral vectors, making them thus good candidates for minimally invasive neuroprotective gene therapy of ALS. We therefore with this PoC grant want to investigate the transduction of NHP MNs  via i.m. injections. We aim to have
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Assessing the aerosol radiative impact employing advanced methods to reduce uncertainties in the aerosol optical properties' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Understanding how anthropogenic aerosols impact the Earth’s climate system is a daunting challenge. Aerosol radiative effects are strongly dependent on the optical and microphysical properties of the particles. Uncertainties in the absorption coefficient and the single scattering albedo (SSA) contribute significantly to the overall uncertainties in the optical properties of aerosol and their radiative effect. Not only does hydration cause an increase in size, but it also alters the complex refractive index (RI) of the particle; the real part of the RI governs the scattering of light by the aerosol and the imaginary part the degree of absorption. Thus, quantifying the relationships of chemical composition, relative humidity (RH) and particle phase with complex RI is critical for predicting the aerosol radiative forcing. Since these optical properties determine the magnitude and even the sign of the effect of aerosol on the Earth’s energy balance, it is vital that we understand their range. Although techniques have been developed to measure the scattering and absorption cross-sections of ambient and laboratory particles, interpreting measurements can be challenging. Using a new technique to accurately determine the extinction cross-sections of single particles developed in the Bristol laboratory, we will provide a rigorous assessment of treatments used to characterise the optical properties of aerosol. Of particular emphasis, we will examine the optical properties of mixed-component aerosol and the influence of chemical aging of organic aerosol on light absorption. Crucially, the parameterisations for optical properties that result will then be used to refine (and assess sensitivities of direct forcing to) the treatment of aerosol properties in radiative transfer and glob
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'EUROPEAN UNIVERSITIES OF TECHNOLOGY ALLIANCE RESEARCH AND INNOVATION ACTION' (ENHANCERIA).

assistant: **Innovation**

ENHANCERIA will contribute to the aim of the European Universities: bringing together creative citizens to cooperate across languages, borders and disciplines to address societal challenges, and contribute towards the modernization of universities and the revised European Research Area (ERA). ENHANCERIA will support and strengthen the research and innovation dimensions of ENHANCE, the European Universities of Technology Alliance, through developing a transformation agenda for the alliance focusing on the role of universities as drivers and enablers of sustainable development. Focus will be on four areas: sustainable development through transdisciplinary research, sustainable entrepreneurship and innovation ecosystems, human resource development, and research infrastructures. ENHANCERIA will enable ENHANCE to include all core activities of modern universities - education, research and innovation (including service to society) - in the activities of the alliance. In developing an institutional transformation agenda the partners will explore, exchange and develop measures towards achieving the long-term vision of ENHANCE: driving responsible societal transformation through a strong alliance of European Universities of Technology.Sub-objectives of ENHANCERIA are:-Exploring practices, ways of working and structures across the alliance-Establishing and widening international networks of employees within research and innovation -Developing models for collaboration and recommendations for implementation-Disseminating and exchanging models and practices-Increasing the internationalization of research and innovation activities-Identifying challenges and barriers at institutional, national and European level-Developing new initiatives to be funded through internal, national and in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Molecular mechanisms of mRNA decay' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

All organisms require a reliable mechanism to turn genes on and off. This regulation of gene expression underlies cellular processes ranging from the response to environmental signals to the development of multi-cellular organisms and cell-cell communication. Understandably, the cell tightly controls gene expression at every step from DNA to protein. Recent work has given new insights into these control mechanisms and revealed dedicated pathways (including non sense mediated decay) that target mRNA for degradation, thereby efficiently turning genes off.  Here, we propose to study the molecular mechanism that underlies the degradation of mRNA. Although many of the proteins involved have been identified, little is know about how the activity of the degradation machinery is regulated on an atomic level. We will study one of the core components, the DCP1:DCP2 decapping complex, that removes the protecting 5' cap structure from the mRNA. Specific question we will address range from the structure of the complex in solution, the catalytically important molecular motions and the way protein-protein or protein-RNA interactions can either activate or inhibit the activity of the decapping complex. We will use of nuclear magnetic resonance spectroscopy, to study these structure, motions and interactions. As these complexes involved can be of high molecular weight, we will exploit recently developed NMR methodology in concert with novel sample preparation techniques. In addition, we will extend our structural studies with in-vivo studies, where we can study the effect of mutations in residues that were found to be important for function. The interdisciplinary nature of this project and the use of a state-of-the-art structural approach promises to provide unique insights into the way