RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Making The Invisible Visible for Off-Highway Machinery by Conveying Extended Reality Technologies'.

assistant: **Concept**

THEIA-XR (Making the invisible visible for off-highway machinery by conveying extended reality technologies) aims at improving human-machine interaction in mobile machinery by enhancing user technology fit and extending reality technologies and functionalities. The results will make the invisible visible respectively the non-perceivable perceivable to the human operator, extending the perceivable range of the operator without negatively influencing the performance of the human while controlling the machinery. The project will ensure positive impact of eXtended Reality technologies on the safety, security trustworthiness and societal aspects of the interaction between the machine, the human operator and public/non-users, and furthermore create an XR workplace that enables positive user experiences of self-efficacy and meaningfulness of work.THEIA-XR will leverage a human-centred transdisciplinary and scenario-based co-design methodology with users, stakeholders and multidisciplinary researchers as a fully integrated project team. This methodology serves to collect human requirements and to design, develop and deploy the extended reality technologies for information presentation and interaction in the off-highway domain. The targeted extended reality technologies will enhance conventional human-machine interfaces through multi-modal information and interaction technologies, deploying innovative data visualization methods, force feedback technology and acoustic information.The THEIA-XR approach for improving the human operator tasks by deploying extended reality technologies will be initially validated and tested in three uses cases in the off-highway domain, targeting snow grooming, logistics and construction scenarios, integrating real end-users, public/non-users and rea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Euro-African Open Biomedical Engineering e-Platform for Innovation through Education' under Horizon 2020.

assistant: **Concept**

The project aims at creating an EU-Africa e-Infrastructure, UBORA, for open source co-design of new solutions to face the current and future healthcare challenges of both continents, by exploiting networking, knowledge on rapid prototyping of new ideas and sharing of safety criteria and performance data. The e-infrastructure will foster advances in education and the development of innovative solutions in Biomedical Engineering (BME), both of which are flywheels for European and African economies. It is conceived as a virtual platform for generating, exchanging, improving and implementing creative ideas in BME underpinned by a solid safety assessment framework. Besides the provision of resources with designs, blueprints and support on safety assessment and harmonisation, specific sections for needs identification, project management, repositories and fund raising are also foreseen. UBORA (“excellence” in Swahili) brings together European and African Universities and their associated technological hubs (supporting biomedical prototyping laboratories and incubators), national and international policymakers and committed and credible stakeholders propelled by a series of Summer Schools and Competitions. In a nutshell, UBORA couples the open design philosophy with Europe’s leadership in quality control and safety assurance, guaranteeing better health and new opportunities for growth and innovation.


**Keywords:** Biomedical devices, safety, open design, knowledge sharing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Plasma cell heterogeneity and dynamics in patient tumors' under Horizon 2020.

assistant: **Concept**

During the last decade, the ability to treat cancer by targeting the immune system has revolutionized cancer care, but many patients still fail to respond to current immunotherapies, which mainly target T cells. Besides T cells, the tumor microenvironment is home to many other immune cells; however, we are still unable to accurately predict and target the functions of most tumor-infiltrating immune cells, particularly in human cancer. These cells and their tumor-associated functions represent an untapped reservoir of therapeutic targets. Plasma cells (PC), which are antibody-producing cells derived from B cells, frequently infiltrate solid tumors and their presence associates with positive prognosis across cancer types; yet, our knowledge of tumor-infiltrating PC remains limited. The goal of this project is two-fold: first, I aim to use single cell RNA-seq coupled with spatial transcriptomics (developed by the host lab) to define the heterogeneity and spatial distribution of PC (and their subsets) relative to other cells/histological features in patient breast tumors. PC receptor expression and survival factors will be mapped to generate a PC-tumor stroma 'interactome', which should facilitate defining potential vantage points for therapy. Second, I aim to define the cellular age of tumor-infiltrating PC, since knowing how cells are replaced in a tissue could be highly relevant to both uncover fundamental cell turnover mechanisms and to define new therapeutic avenues. The combination of skillsets between the applicant (tumor immunology) and the host lab (spatial transcriptomics and carbon dating, the latter which uniquely can be used to determine cellular lifespan in humans) presents a unique opportunity for the feasibility and knowledge exchange involved in performing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Driving next generation autophagy researchers towards translation'.

assistant: **Concept**

The manipulation of autophagy has an enormous therapeutic potential to revolutionize the way we currently treat cancers, neurodegenerative disorders, inflammatory and infectious diseases. Despite the great promises made by pioneering medical studies, the still limited applied research on autophagy has hampered the translation of fundamental knowledge into clinical-grade products and improved healthcare. Applied autophagy research is essential to understand the roles of autophagy in the different physiological and pathological situations, to generate (disease) models and develop biomarkers and assays to assess its progress.The goal of the ETN Driving next generation autophagy researchers towards translation (DRIVE) is to train young scientists to fill this gap. DRIVE will equip its ESRs with an unique combination of knowledge and experimental expertise that are brought together in this consortium by the different partners. The realization of their projects in applied autophagy research will benefit of an exceptional interdisciplinary platform integrating cell biology, biochemistry, molecular biology, genetics, chemistry and “omics” approaches. In addition, DRIVE ESRs will acquire competencies to exploit the results for the development of products and techniques of commercial value. These ESRs will also be trained in disseminating results and knowledge through modern channels of communication.


**Keywords:** Autophagy, biomarkers, assays, in vivo models, applied research, physiology, pathology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The European Union in the Arctic' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The European Union in the Arctic (EURARCTIKA) research project’s objective is to investigate which legal and geopolitical instruments the EU could use in order to contribute to the protection of the Arctic environment. The timeliness of this issue is due to the fact that the Arctic is warming at a rate of almost twice the global average, which is making energy resources and transportation routes much more accessible while jeopardizing the environment at the same time.The EU is an important actor in the Arctic where it has geopolitical and economic interests. Additionally, the EU has a distinct negative impact on the Arctic environment with its greenhouse gases and black carbon emissions. For this reason, the EU should take responsibility for its impact on the Arctic and play a role in the protection of its environment. EURARCTIKA combines two branches of international studies (law and international relations). These latter analyse the same phenomenon from different perspectives that are however complementary offering a complete analysis of the object of study. EURARCTIKA will first analyse the main features of the Arctic legal regime for environmental protection and will identify its main strengths and weaknesses in order to evaluate its effectiveness. It will subsequently focus on the geopolitical and economic interests of the EU and of states in the region and the implications at the international level. Finally, the project will investigate the measures, the instruments, and the strategies that the EU can use to contribute to develop an effective environmental regime in the region in order to protect the Arctic environment.Through an extensive dissimination of the research results (open-access publications, a high-level conference, workshops participation and present
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Swimming for reproduction (REPRO-SWIM): Identification of swimming induced metabolic and hormonal switches that trigger reproduction'.

assistant: **Innovation**

A long standing question in the reproductive physiology of fish is how the metabolic status determines the onset of sexual reproduction, which often coincides with the start of reproductive migration. We hypothesize that swimming in that case triggers metabolic and hormonal changes critical for the induction of maturation. Studies on migrant fish like eel and salmon support the hypothesis that swimming triggers sexual reproduction, mobilises energy reserves for fuel and positively influences gamete quality. The mechanism behind this is however non-elucidated. Exercise, such as performed by migratory species, can be used as an experimental factor in studying the interaction between the metabolic processes and the onset of sexual maturation. This knowledge is important in optimising aquaculture of commercially interesting species, taking rainbow trout as a model. This study will identify the key metabolic and hormonal factors and their expression profiles in the onset of sexual reproduction as induced by swimming. Using microarray technology, the transcriptional response to exercise of all important tissues involved - gonad, muscle, liver, fat, brain and pituitary - will be analysed in a holistic approach. The main genes involved in both reproductive and metabolic functions will be identified. The role of insulin-like growth factors, the most important candidates, will be established. The expression profile of the main identified genes will be confirmed by real time PCR. The function of the main regulated genes will be investigated in vivo by implanting zebrafish cells that express each of the selected genes. The career objective of the applicant is to acquire additional skills and expertise in becoming a multidisciplinary fish reproduction expert. In addition he would ha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Retinal imaging prevention and early detection of chronic diseases'.

assistant: **Concept**

The overall objective of the RETINAL initiative of ULMA Embedded Solutions is to develop non-invasive and cost-effective tools with capacity for prevention and/or early detection of various diseases related to NCD complications, by analyzing the changes in the microvasculature of the retina.The basic framework of RETINAL is a comprehensive solution for ophthalmic imaging analysis and treatment composed of a simple, reliable and cost-effective color fundus digital image capture device and several specific software modules associated to the device for a number of specific clinical applications.The goal of this action is to demonstrate in the market, by independent peers, that RETINAL is the best available and cost-effective technology for the detection of diabetic retinopathy in DR Screening Programmes, and particularly valuable for its implementation at primary health centres, which makes screening more accessible to patients and therefore more effectiveThe overall objective of the RETINAL initiative of ULMA Embedded Solutions is to develop non-invasive and cost-effective tools with capacity for prevention and/or early detection of various diseases related to NCD complications, by analyzing the changes in the microvasculature of the retina.The basic framework of RETINAL is a comprehensive solution for ophthalmic imaging analysis and treatment composed of a simple, reliable and cost-effective color fundus digital image capture device and several specific software modules associated to the device for a number of specific clinical applications.The goal of this action is to demonstrate in the market, by independent peers, that RETINAL is the best available and cost-effective technology for the detection of diabetic retinopathy in DR Screening Programmes, and particularly val
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development of a Novel Autonomous Non-Invasive Absolute Intracranial Pressure Measurement Device Based on Ultrasound Doppler Technology'.

assistant: **Innovation**

The BrainSafe II project builds upon a successful Research for the Benefit of SMEs project and will deliver an innovative technology for the autonomous, calibration free, non-invasive, rapid, accurate and precise absolute intracranial pressure (aICP) determination. The resultant device will exhibit absolute intracranial pressure measurement to within SD = ± 2,5 mmHg. The target time for the whole procedure is 9 minutes (compared with a current average 23 minutes). The device resulting from this research will be a very significant breakthrough in healthcare delivery. The timely application of the device in the diagnosis of TBI patients will save approximately 9,400 lives, reduce the number of permanently disabled citizens by 30,000 and increase the survival rates and lifespan for an additional 136,000 patients with TBI within the EU annually. The BrainSafe II concept is initiated by the SME Vittamed who has background knowledge and holds all background IPR of the proposed technological concept. The R&D will be completed by a consortium of experts within ultrasonic techniques, signal processing, microdrivers and ergonomic hardware design to ensure full safety and comfort to patients and ease of use and time saving for medical personnel. The RTOs are Kaunas University of Technology in Kaunas, Lithuania, Singer Instruments and Control Ltd. in Israel and Estonia Innovation Institute. The SME partners joining Vittamed form a coherent supply chain with the skills to manufacture and distribute the final product. The SMEs  are Microplast, for high precision plastics moulding, Medelkom for its expertise with ultrasound transducers, Artec Design for electronic subsystems and Vittamed  for signal processing software.  Following, clinical trials, widespread adoption of the technolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Educational Common Spaces. Passing through enclosures and reversing inequalities'.

assistant: **Objectives**

SMOOTH intends to introduce the emergent paradigm of the ‘commons’ as an alternative value and action system in the field of education for children and young people. The project critically draws out the implications of the commons for refiguring education and for social change in general, on a footing of equality, sharing, participation, togetherness, caring and freedom. The project will address social inclusion according to the ‘educational commons’, which we want to study, if they can operate as a catalyst for reversing inequalities, through a variety of methods such as pedagogical documentation, pedagogy of active listening, ethnography, discourse analysis.In particular, it proposes an innovative action research program with and by children to: a. reverse inequalities faced by children from vulnerable social groups; b. strengthen inter-cultural and inter-generational dialogue and social integration;c. develop vital social and personal skills for the children and adults; d. create smooth spaces of democratic citizenship and experimentation with new ways of thinking and doing on the basis of equality, collaboration, collective creativity, sharing and caring; e. build and foster community through differences.Universities, research labs, municipalities, NGOs, museums, and youth organizations, in different countries, will work interdisciplinary and interculturally together to achieve the above aims from the point of view of educational commons. Specifically, various case studies will be conducted in educational premises to reverse the existing inequalities and achieve an active social exclusion for vulnerable children and youth. In short, a cross-cutting, cross-disciplinary analysis about the role of educational commons must be seen as crucial to provide policymakers new,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovation Relay Centre For Scotland' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The objective for the period 2004-08 is for IRC Scotland to involve more Scottish players in the process of transnational technology transfer and transnational technology co-operation . Streamlined project management, strong client focus, a pan-Scottish remit and close collaboration with our IRC colleagues in Europe lend strength to the proposal: Strengths which all support the Specific Programme's action ( Structuring the ERA " Research and Innovation) which calls for the IRC The objective is heavily underpinned by Scottish Executive's Policy document outlining a Vision for a "Smart Successful Scotland": IRC Scotland is hence also highly pertinent to regional research and innovation needs. The 2 Scottish Regional Development Agencies (known as the Enterprise Networks) are key in delivering this Vision. The 2004-08 Workplan focuses on how IRC Scotland will align its services with the Enterprise Networks' innovation, growth and globalisation strategies and integrate into their regional and local business support systems: IRC Scotland will provide its services in synergy with national and regional support structures. The Workplan will be delivered through 3 integrated Workpackages. The first addresses the delivery of services which stimulate, encourage and support the trans European commercialisation of technologies, research and innovation. It looks at the intermeshing of these services with complementary EU networks and with regional/national service providers. The second focuses on effective collaborative working within the IRC network, contributing to overall quality, and underpinning its trans European-remit and unique strength. The third concentrates on efficient streamlined management, the quality and client focus of IRC Scotland services, and its strategic marketi