RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Accelerating Climate Action: Navigating towards a Low-Emissions, Climate-Resilient Future' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The overall objective of ACCLIMATE is to achieve enhanced integrated national and international strategies for climate-resilient, low-emission development. ACCLIMATE will contribute to improving the transparency, consistency, and clarity of GHG emission reduction commitments and create appropriate tools by developing an assessment framework for mitigation commitments. Working in a bottom-up manner with national experts within an international consortium comprising high-emitting countries from the Americas, Asia and Europe, as well as low-emitting countries from West Africa, ACCLIMATE will identify needs for improvements of NDCs and long-term strategies. A focus will be set on adequacy, fairness and feasibility, as well as on needs for improving current policies and measures to actually achieve NDCs and long-term objectives. On this basis, the development of enhanced national strategies and pathways will similarly build on existing scientific national expertise and models, with the development of enhanced pathways for all focus countries being undertaken by the respective partners of the consortium based in these countries, with support from European partners. These pathways will include an increased understanding of the role of ecosystems, non-CO2 gases, and climate impacts and risks, and socioeconomic tradeoffs. The development of enhanced pathways and policy recommendations will build on sectoral deep dives in order to fully capture sector-specific mitigation enablers and barriers. ACCLIMATE will in particular focus on the sectors industry, buildings, AFOLU, transport, and energy supply. ACCLIMATE will enhance the capacity in partner countries to develop and model mitigation strategies and pathways and to analyse and develop respective policy strategies and packages.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'In-Silico Prediction of gene function', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The GENEFUN project aims at addressing two important issues. Improving existing sequence-similarity based function annotation tools, and developing and integrating methods that consider information on 3D structure as well as on physical and functional interactions between genes and proteins and the processes in which they are involved. 1- It will develop criteria for evaluating the reliability of the annotations currently available in databases. These criteria will be used to assign reliability scores to these annotations and will be incorporated into standard annotation pipelines, for future use. 2- Higher-level features will be incorporated into functional annotations by combining sequence and structure information in order to identify non-linear functional features (interaction sites) and by integrating different methods for inferring function from context-based information (domain architecture, protein-protein interaction, gene order etc.). To achieve these goals several European groups with a strong track record in various aspects of bioinformatics have teamed up with an experimental group from Canada, which is well known for its strength in structural and functional proteomics. The expected output of the project is: improved procedures for inferring function on the basis of sequence similarity, a set of procedures for predicting non-linear functional features from sequence and 3D structure, and benchmarked procedures for predicting context-based functional features. Major efforts will be devoted to protocols that optimally combine the results from several methods. These protocols will be made available to the scientific community via the Web, and the community will be introduced to them through open workshops and training sessions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Addressing the impact of surface ectoderm and somitic mesoderm development on neural tube morphogenesis.'.

assistant: **Innovation**

Neural tube closure (NTC) is a fundamental process during vertebrate embryogenesis, which leads to the formation of the central nervous system. Defective NTC leads to neural tube defects (NTDs), which are one of the most common human birth defects. During NTC Convergent Extension (CE) leads to the narrowing and elongation of the neural plate (NP) and Apical Constriction (AC) drives the bending of the tissue. While the role of the aforementioned morphogenetic events for NTC has been studied extensively how the development of tissues mechanically coupled with the NP affects NTC remains poorly understood. Here, we aim to elucidate the influence of surface ectoderm (SE) and somitic mesoderm (SM) morphogenesis on NTC. To achieve our goals, we will employ an interdisciplinary research plan using Xenopus laevis and mouse embryos as model systems.  First, to understand the contribution of SE and SM morphogenesis on NTC (AC and CE) we will specifically inhibit these processes using morpholino mediated protein knock-down in Xenopus embryos and tissue-specific knock-out and knock-in models in mice embryos.  Subsequently, we will directly assess the impact of SE and SM tissue tension on NTC by modulating tissue tension in Xenopus embryos through optogenetic tools and mutant constructs in conjunction with live imaging. We will go on to examine how SE and SM influence the mechanical landscape of the NP using force inference techniques in Xenopus and mouse embryos in conjunction with loss of function approaches described above. Finally, we will examine how mechanical coupling between the NP with both the SE and SM affects the mechanosensitive elements responsible for CE and AC. Overall the data produced by the proposed work will uncover the role of SE and SM morphogenesis on NTC expan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Value chain generator to accelerate the European transition to circular economy' (VCG) under Horizon Europe.

assistant: **Objectives**

Out of 100 billion tons of resources entering the economy every year - from metals, minerals, and fossil fuels to organic materials - only 7.2% are circled back. This is a decline from 9.1% in 2018, and 8.6% in 2022, despite over 100 billion EUR private and public investments into circular economy in the EU. Solving this problem can lead to 4.5 trillion EUR of business opportunities, 6 million high value-added jobs and a potential to reduce the global GHGE by 39%.Value chain generator (VCG) offers a promising way to solve those problems by exploiting deep tech and novel approaches to build circular value chains, which have emerged as a strategic EU tool to direct decarbonization investments and improve resource efficiency. It is a cloud platform that uses AI and big data to digitally and in real-time build circular value chains enabling the exchange of (industrial) residuals between millions of companies embracing circularity. For example, 42 million tons of Brewers Spent Grain, the main by-product of the beer brewing process, can be turned into raw material for bioplastics, biofuel, alternative proteins, or chemicals, which are in high demand in the automotive, pharma, food and beverages, and the energy industries, with a ROI of 172% for a mid-sized brewery and GHGE savings of 19,387 tons of CO2 or 5,291 tons of carbon annually.Exploring multidimensional synergies between materials, technologies, and climate/financial metrics, VCG enables businesses to make informed decisions and investments, fostering a circular economy that decarbonize supply chains, minimizes waste (potential to valorize over 100 million tons of residuals by 2032), reduces CO2 emissions (64 million tons savings by 2032), and maximizes ROI (up to 600%). To keep the competitive edge, adhere to the amb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Lossless Electron Beam Monochromator for Enhanced Resolution in Electron Microscopy', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Lossless Electron Beam Monochromator for Enhanced Resolution in Electron MicroscopyThe performance of advanced high-resolution electron-microscopes (EM) is severely limited by the energy spread of the electron beam, which limits both spatial and spectral resolutions by causing chromatic aberrations. To mitigate this limitation, monochromators are used. Common monochromators have mechanical slits as a narrow band-pass filter, inherently introducing high loss to the electron beam. They are very complex and thus highly expensive. Here we propose to develop a novel electron monochromator technology that is lossless, relatively simple (and thus, cost-effective), and modular, so it can potentially be installed as an upgrade in a wide range of existing EM systems. The proposed monochromator compresses the electron energy rather than filtering it, and thus the resulting electron beam suffers no losses. We use a single crystal, located inside the microscope column, close to the incoming electron beam. Infrared laser pulses are used to generate THz radiation in the crystal which interacts with the electron beam such that the energy of the electron beam is compressed without introducing electron losses. We aim to achieve this through three main goals: (1) Demonstrate the ability to get strong energy compression in pulsed electron mode with the advantage of low losses. (2) Demonstrate that our idea can also upgrade the performance of traditional low-cost CW operating EM such as low-voltage scanning EM (LV-SEM). (3) Commercialize our IP and penetrate the market. We developed new IP, aiming to commercialize the technology at the end of the project. We are in contact with microscope manufacturers expressing interest in our innovation. Our lossless electron beam monochromator is expect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Total control of flowability of polyester compounds'.

assistant: **Innovation**

With polyester moulding compounds (SMC, BMC) a major quantity of scrap both in producing compound and moulding is caused by the lack of control of the moulding properties. The scrap rate is ranging from 1 to 3 % up to ca. 15 % with an additional rate of 50 to 75 % of parts to be reworked and repaired. Especially the uncontrolled flow properties produce a varity of unwanted technical effects and must be seen as one basic reason for that situation. The task is to establish a Total Control of the Flowability of compounds along the whole sequence of processing. The control shall include assessing of the individual stages of the material. Since flowability is a physical property, a correlation with QA specification elements of the moulded part must be established, using always compatible physical expressions. Interfaces and programme modules must be defined for the control of each following step. The platform for the definition of flowability shall be given by the raw materials (level of causes) and shall be traced and controlled at the interfaces (level of effects) to finally result in a defined QA specification of the part. A cost reduction of ca. 5 % shall be achieved by reducing scrap, increasing productivity and reducing rework. Additionally an important increase of the market is expected from constant and reliable quality.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Electronic Structures Sono-Engineering of Semiconductor Nanoparticles for Efficient Solar Energy Exploitation' in the context of a Seventh Framework call.

assistant: **Objectives**

This research aims to harness ultrasonication as innovative thermal treatment tool to effectively engineer the electronic structures of colloidal particles. The main objectives of this project are: 1) to develop various interfacial strategies to establish a general and innovative low cost ultrasonication based thermal treatment protocol; 2) to gain novel and effective sono-engineering methodologies for introducing intrinsic/extrinsic defects in seminconductor nanoparticles; and 3) to acquire innovatively enhanced photovoltaic behaviors of from the sono-engineered semiconductor nanostructures.The anticipated thermal treatment will be easy, cheap, easily accessible, and feasible for massive production in comparison with conventional black-body-radiation-based thermal treatment. This will enable one to gain in-depth insight to the physics of acoustic bubbles and especially the energy release during bubble collapse and to effectively transform existing semiconductor particles to be photovoltaic and photoelectrochemical more active for efficient storage and conversion of solar energy and exploitation, thus making a significant step forwards in solar energy exploitation.The proposed project is a multidisciplinary one, and the results of the project can be of great interest for scientists and engineers from diverse areas including colloids and interface science, material science, nanotechnology, condensed matter physics, sonochemistry, electrochemisty and photovoltaics. According to the project objectives, the proposed project contributes to the “Nanosciences, Nanotechnologies, Materials and new Production Technologies (NMP)”, one of the themes of the 7th European Framework Cooperation Programme. Successfully carrying out of this project will result in significant economic, en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'T cell responsiveness and productive antigens filariasis vaccine de velopment' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

* To identify protective antigens in lymphatic Filariasis suitable for vaccine use.* To measure human antibody and T cell responses to these antigens. * To clone and express major T cell immunogens as recombinants.* To express selected recombinant filarial antigens for vaccine tests in animals.* To enhance expertise and research resources of endemic count scientists.Expected Outcome* Identification of a panel of immune individuals whose serological and lymphocyte reactivities will define key in immunity.* Identification of the major T cell antigens in lymphatic Filariasis, and their cloning and expression in a variety of vectors.* Evaluation of potential vaccine antigens against lymphatic Filariasis in rodent model systems.* Identification of subjects exposed to Filariasis transmission but show evident immunity.* Measurement of antibody responses to a range of recombinant antigens.* Identification and cloning of filarial antigens which most strongly stimulate T cells.* Analysis of different geographic strains of Brugia malayi.* Expression of filarial T cell for vaccine testing in rodent models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unravelling the Nascent Code: Signals sensed and transmitted by the nascent chain to acquire its functional state or reprogram gene expression' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Emerging biochemical and biophysical data strongly suggest that the transformation of the potential set of proteins, encrypted in the genome, into its actual vital functional set, is a manifestation not just of the genetic code, but of an additional layer of information encoded within the newly synthesized polypeptide nascent chain. To date, we know that immediately upon the first steps of protein synthesis, a variety of signals are formed within the evolving nascent chain (NC). These signals, by acting directly on the ribosome or by recruiting additional cellular machines, have the ability to direct new steps in the transformation of the NC and guide it towards the acquisition of its final functional state and cellular location. Due to its distinct nature, I will refer this ensemble of signals as THE NASCENT CODE. Despite our knowledge of its existence, we know very little about its mechanism of action. The goal of this research is to unravel the molecular determinants of the nascent code and to decipher how the signals, embedded in the primary sequence of the NC, orchestrate the concerted action of the ribosome and its ancillary factors (i,e, SecA, TF). The approach entails the reconstructing of the process describing the birth of a protein and following its progress over time. The techniques used in the analysis of this process, namely fluorescence spectroscopy, Cryo electron microscopy, solid state NMR-DNP, solution state NMR and X-ray crystallography, will illuminate macroscopic to atomic level details of the dynamics, structure and interactions of the key players involved. The realization of this research project will allow us to understand an essential process in the cell, for which very little structural information is currently available, and provide the struct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ENRICHMENT OF AQUACULTURE IMPLANTS BY INTRODUCTION OF NEW MARINE SPECIES FROM THE WILD TO BREEDING', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

We propose a two years work, aiming at optimising sea urchin Paracentrotus lividus rearing, in order to enrich pre-existing aquaculture farms (based on sea bass, bream, and/or different bivalves) . Sea urchin breeding will be performed starting from adult specimens obtained from capture. Sea urchin roe (gonads) are first class food and are worldwide commercialised. This project arises from the increasing demand of sea urchin roes and is addressed to the feasibility of sea urchin aquaculture, broodstock and gonad improvement. In the last fifteen years, the aquaculture of sea urchin has been carried out by non-European factories, mainly in Japan, USA and Canada. Unsexed whole sea urchins or their processed gonads are shipped primarily to Japanese markets and to markets in France, Belgium, Greece, Italy and Turkey. The demand in these European Countries is at present partially fulfilled by a high fishing pressure on wild sea urchins, that in some areas (France, Greece) are at risk and protected species. A number of European and ICPC SMEs, dealing with aquaculture, are strongly interested to carry on a research focused at 2 main objectives: 1-to insert sea urchin aquaculture in their activities, in order to enrich and diversify their production, that is already going on with different marine species. 2- to obtain an environmentally friendly expansion of their activity, in order to increase sustainability and prevent environmental impact. The involved SMEs aim at obtaining know how and possibly patents to be invested in their activity, and need RTD activities and training of operators for overcoming problems and enhance competitivity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Testing of safety and performance indicators' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Existing performance assessment studies for final repositories use only dose rates as indicators for the long-term safety. Additional information, however, could be gained from other indicators such as concentrations or release rates in specific parts of the disposal system. Those indicators are often called safety indicators, if they refer to the safety of the total disposal system and performance indicators, if they refer to the performance of subsystems. The proposed project intends to identify a number of different safety and performance indicators and to test their suitability for evaluating the long term performance of disposal systems. The mentioned work will be done by re-calculating different existing studies with different tools, which have to be slightly modified in order to calculate the indicators. The suitability of indicators will be tested by intercomparing the results as well as by comparing with reference values.Modified performance assessment codes have been generated. All other usable outcome of the project is covered by the deliverables, mainly the Final Scientific Report. This is foremost the knowledge about the usefulness of specific indicators for safety and performance assessment purposes.