RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Characterisation of the molecular mechanisms determining the rna nuclear export pathways' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Cells use distinct mechanisms to move different classes of RNA from their nuclear site of synthesis to the cytoplasm, including mRNA and U snRNA. Major spliceosomal U snRNAs and mRNAs share similarities in their synthesis : their precursors are transcribed in the nucleus by RNA polymerize II and acquire a m7G cap structure, bound by the nuclear cap-binding complex (CBC). Despite these similarities and the fact that in both cases there are no conserved internal RNA sequences required for nuclear export, U snRNAs and mRNAs are exported in metazoa by different factors. U snRNAs are exported in a complex containing CBC, PHAX (phosphorylated adaptor for RNA export), the export receptor CRM1/Xpo1 and the GTPase Ran. Interestingly, export of mRNAs does not require these factors but depends upon the REF and TAP/NXF1 proteins . Thus , there must be distinguishing features of U snRNAs and mRNAs that are recognized by these cellular factors. One obvious difference is that rnRNA precursors often contain introns whereas u snRNAs do not. It is particularly intriguing to investigate if the presence of an intron can commit a U snRNA to the rnRNA nuclear export pathway and determine if the mRNA specific factors imprinted onto the RNA during splicing can remodel the U1snRNA export. The aim of this project is to understand the molecular mechanisms that determine the two RNA nuclear export pathways and provide new insights as to how the export pathways are distinguished.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Design, Build and Test of novel bacteria-delivered proteins for cancer therapy' (BacStar).

assistant: **Concept**

Conventional cancer therapies have many limitations that could potentially be overcome using engineered tumour targeting bacteria as cancer therapeutics. These bacteria have been shown to selectively grow in tumours where they can produce and deliver therapeutic biomolecules (proteins) extracellularly in the tumour microenvironment. However, the delivery of these biomolecules into the cytoplasm of targeted tumour cells remains a challenge, limiting the clinical translation of these therapies. BacStar aims to address delivery challenges by designing multi-part, multifunctional proteins that transport themselves from the interior of the bacterium into the cytoplasm of cancer cells where they can exert therapeutic action. These proteins will integrate protein motifs for transport (using novel cell penetrating peptides) and anticancer activity, which will be assembled using recently developed computational protein design workflows. A modular design-build-test synthetic biology approach will facilitate measurability and experimental throughput. Novel proteins will be tested in vitro and in vivo with high-throughput methods available at host labs. This interdisciplinary approach is enabled by leveraging cutting-edge expertise and technologies in computational protein design from the Bhardwaj and Baker Lab at the Institute for Protein Design, UW (USA) and in bacterial cancer therapy available at the Tangney Lab, UCC (Ireland). An international intersectoral placement at Prokarium (UK) will support the clinical translation of outputs from this project and build my expertise in translational research, which will inform the commercialisation route of this and future projects. My long-term career aim is to develop bacteria-delivered protein therapeutics. BacStar is a significant c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Marie curie training site for bioinformatics education and research' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

PhD students from across Europe are invited to apply for a stay of up to 12 months at the University of Manchester, Bioinformatics Education and Research (UMBER)' ' site. As a Marie Curie Fellow you will learn a broad range of skills in this rapidly expanding and most sought after field. You are given the opportunity to take modules in our ground-bracing MSc course and participate in individual and group research projects. You may participate on an a la carte basis in the M.Res. Programme and may obtain a graduate degree in Bioinformatics in addition to your PhD from your home institution. The Bioinformatics MSc Course is very popular, well established, complemented by a distance learning course and the EU-wide EMBER project, which aims to develop a Multimedia Bioinformatics Educational Resource (see www.bioinf.man.ac.uk/teaching for information). The program comprises lecture courses and practical including theory and application of bioinformatics methods, communication, programming, academic and industrial modules. UMBER, a joint operation between the School of Biological Sciences and Computer Science, has 9 members of staff, and combines world class research with a truly unique selection of subjects comprising theoretical biology, databases, genomic, proteomics, sequence analysis, ontologies, pathway modelling, array analysis, molecular modeling and many others. Excellent equipment in hardware and software and a highly skilled support team are available. This call is typically for students in IT or life sciences who have had, so far, little or no bioinformatics experience and wish to learn theory and application of methods to support their PhD and future career. Manchester is very lively, dynamic and multi-cultural, with many students, a rich choice of cultural, soci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Eu proposal: financial support for the organisation of the 10 th congress of the african association of biological nitrogen fixation(aabnf), accra, ghana, october 21-25, 2002.'.

assistant: **Concept**

In most tropical soils nitrogen is the most important element that limits crop yield. Traditionally soil nutrient deficiency have been corrected through the application of chemical fertilizers. However, most farmers in Africa cannot afford the high cost of inorganic fertilizers leading to impoverished soils with concurrent low crop yields. Biological Nitrogen Fixation (BNF) an inexpensive and ecologically sound process is capable of supplying the nitrogen needs of many plants and if well managed can assist in the restoration of soil fertility and high crop yields. The African Association of Biological Nitrogen Fixation (AABNF) was founded in 1984. A major aim of the association is to bring scientists working on BNF closer together to exchange research ideas and to discuss strategies for enhancing the use and benefits from BNF in agriculture and the environment. Members of the Association have since been meeting every other year at a selected venue. In addition to the African scientists their counterparts from Europe and other continents who may be working on the state of the art areas in BNF are invited to present their research findings and who eventually become mentors for postgraduate students. These benefits are evidence of contributions made by the European counterparts towards capacity building and collaborative research. The AABNF has usually depended ...
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of improved pest risk analysis techniques for quarantine pests, using pinewood nematode, bursaphelenchus xylophilus, in Portugal as a model system' (PHRAME) targeting Fifth Framework.

assistant: **Abstract**

The detection of pinewood nematode (PWN), Bursaphelenchus xylophilus, in Portugal has increased the threat to the EU from this extremely dangerous pest. The Consortium will improve current Pest Risk Analysis (PRA) methodology by:(1) Gathering data on the biology and likely impacts of PWN and its vectors in Europe.(2) Developing and testing survey methodology to assess the taxonomy and distribution of PWN and its Monochamus vectors on the Iberian peninsula and elsewhere.(3) Establishing live cultures of Bursaphelenchus for pathogenicity testing on pines in Europe.(4) Using genetic similarity to carry out pathway analysis to determine the origin of the Portuguese isolate(s) of PWN.(5) Determining eco-climatic requirements of PWN and its vectors to improve knowledge on the pest-vector relationship.(6) Constructing new PRA models and testing them for PWN and other quarantine pests.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'TIMELAPSE. A VR application for speeding up time passage during chemotherapy'.

assistant: **Innovation**

Chemotherapy can involve lengthy treatment sessions, lasting up to several hours. Such a duration, spent in an overly medicalized setting, can induce in the patients a monopolizing focus on their pathology, which leads to a substantial decrease in their mental well-being.One way to alleviate the impact of long chemotherapy sessions would be accelerating subjective time passage as perceived by the patients, therefore making the treatment seemingly end more quickly.Stemming from the ERC Advanced Grant AN-ICON, the TIMELAPSE project proposes to prototype, test, and launch on the market a virtual reality (VR) application that will accelerate subjective time passage during chemotherapy. The idea, whose singular aspects were the object of previous scientific evidence, was so far not implemented comprehensively. TIMELAPSE will fill this R&D gap with unprecedented methods and targets, adopting a patient-centred approach to innovatively incorporate in the conception of the VR application the irreplaceable perspective of its end-users: the oncologic patients.TIMELAPSE will take this idea to proof of concept by means of five subsequent phases: 1. Theoretical elaboration, to shape a theoretical hypothesis concerning what types of VR content might accelerate subjective time passage during chemotherapy; 2. Participatory design, to refine this hypothesis by incorporating the users’ perspective; 3. Production, to develop the content for the VR application, to obtain a prototype ready to be tested. 4. Assessment, to demonstrate the tolerability and effectiveness of the VR application; and 5. Pre-commercialization, to prepare the launch of the VR application on the market. To ensure appropriate methodological tools for each phase, TIMELAPSE will rely on a collaboration between three acto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Descending Control of Motor Circuits in Drosophila' (DeCoDr).

assistant: **Innovation**

Understanding how neural circuits control arm and leg movements is a major challenge in neuroscience with implications for treating movement disorders, designing neural prostheses, and robotics. Limb movements are coordinated by low-level motor circuits in the spinal cord (in vertebrates) or ventral nerve cord (in invertebrates), which receive movement instructions from the brain via a small number of descending neurons (DNs). DNs constitute the critical link between the brain and the body. However, despite their importance, little is known about how specific DNs are recruited depending on the behavioral context, and how low-level motor circuits in the spinal cord or ventral nerve cord translate DN activity into limb movement. I propose leveraging cutting-edge tools to tackle these fundamental questions in the compact nervous system of the fruit fly, Drosophila melanogaster. The fly’s neural circuits for controlling limbs are more tractable and experimentally accessible than those of vertebrates, but still similar in their organization and function. Focussing on DNs that have been implicated in the control of walking speed, I will characterize the activity of DNs during behavior, identify the target neurons of DNs in motor circuits in the ventral nerve cord, and quantify the influence of DNs on these target neurons. By combining intracellular patch-clamp recordings, calcium imaging, and movement tracking in behaving animals with computational modeling and connectomics, the proposed research project will provide unique mechanistic insight into the interactions between the brain and low-level motor circuits that have remained elusive in other animals.


**Keywords:** Motor control, descending neuron, insect, ventral nerve cord, walking, electrophysiology, calcium imaging,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mimicking Adaptation and Plasticity in WORMS' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Traditionally, a robot is a machine controlled by a central unit and used to perform specific tasks automatically, often in a structured environment. MAPWORMS aims at challenging this traditional concept by proposing robots inspired by simplified forms of Marine Annelida, able to performtasks in response to environmental stimuli and to adapt to the environment with a shape-morphing strategy.Smart shape-memory hydrogels, able to respond to different stimuli (ion species, chemicals, light, pH, etc.), represent the building blocks in this new generation of morphing robots. By combining smart reactive hydrogels with nonreactive elements, actuation units able to transduce stiffness variation into geometrical changes will be developed. In the proposed endeavour, biology is the inspiration for simplifying principles to deal with a complex world, material science is the foundation for giving the body its proper role in shaping behaviour, mathematical modelling is the way to describe biological mechanisms to provide hints and laws for the artificial counterpart. Robotics and engineering aim at providing tools to quantitatively and functionally study biology, to bring innovative materials from chemistry labs to working systems, and to provide general purpose actuators and adapting machines.With a team of 6 partners (including 2 SMEs) in 4 years, MAPWORMS intends to: 1) study adaptation and plasticity of the body plan in Marine Annelida and shed light on the specialization process that allowed forms appeared early in the evolution of the Phylum to adapt to different environments; 2) develop a mathematical model of Annelida plasticity and adaptation to the environment through burrowing, protrusion of parts of their bodies, and morphological changes; 3) develop smart soft materials
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The origins of the Acheulean in East Africa'.

assistant: **Innovation**

The disappearance of the earliest human culture, the Oldowan, and its substitution by a new technology 1.6 million years ago, the Acheulean, is one of the main topics in modern Paleoanthropology. However, little is known about the biological and cultural evolutionary mechanisms underlying this process. Traditionally, it has been assumed that this major cultural change was ignited by the emergence of a new human species, Homo ergaster/ erectus, and that there was a steady technological evolution during the Oldowan that eventually led to the emergence of the Acheulean handaxes. However, these assumptions are not grounded in the current available evidence, but rooted in paradigms that should now be superseded.Olduvai Gorge (Tanzania) is the site where the earliest Acheulean was first discovered, and where the traditional view of the Oldowan-Acheulean transition was established. Despite the pivotal role of Olduvai as a sequence of reference for East Africa and elsewhere, the original datasets are now outdated and are unsuitable for current discussions. This proposal aims to solve this problem by conducting a comprehensive research program at Olduvai, based on the retrieval of fresh data derived from new laboratory and fieldwork research. The multidisciplinary character of this study will provide an integrative perspective to the analysis of the paleoecology, archaeology, geology and geochronology of the early Acheulean at Olduvai. Using an innovative theoretical perspective that combines interests in cultural change, ecological adaptations, and biological evolution, and state-of-the-art methods in archaeology, geology, and taphonomy, this project aims to make Olduvai the world’s best reference for understanding of the evolutionary processes that led to the emergence of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biomedical implications of epithelial transporters and channels' to be submitted under Sixth Framework.

assistant: **Abstract**

Membrane transporters and channels are an important class of proteins responsible for moving essential nutrients and minerals into and out of cells. After I pioneered the development of expression cloning for the identification of membrane transport proteins, my laboratory at Harvard Medical School subsequently identified and characterized a variety of nutritionally important epithelial transporters. These include transporters of iron, vitamin C, citrate, glutamate, amino acids and peptides, as well as epithelial calcium channels.With my return to Switzerland last summer, the efforts of my new lab at the University of Berne are being devoted to three major areas of research:1. epithelial calcium channels and pathophysiological implications;2. molecular physiology of iron transport;3. therapeutic applications of membrane transporters and channels.This Marie Curie Reintegration Grant will specifically allow me to elucidate the medical and pathological implications of the epithelial calcium channels TRPV5 and TRPV6. I propose to perform an in-depth genetic examination of the role of the TRPV5 and TRPV6 calcium channels in patients with idiopathic hypercalciuria (collaboration with Prof. Frey). Identification of disease-related variations of these genes may lead to the design of useful diagnostic tools for the examination of patients with Ca2+-related disorders. Furthermore, as a first step towards the development of therapeutic applications, I propose to develop specific inhibitors for the TRPV calcium channels.Our functional assays for the TRPV channels will be ideally suited for designing assays for high throughput screening to identify lead drugs for pharmaceutical developments of novel calcimimetics. The results from these studies may help develop treatment strategies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multi-functionalization of hydroxyapatite for restoration and preventive conservation of marble artworks' under Horizon 2020.

assistant: **Concept**

The HAP4MARBLE Project is aimed at developing a new multi-functional treatment for conservation of marble artworks in Cultural Heritage (CH) and validating it in the field. Marble has been widely used in architecture and sculpture since antiquity, but it is subject to several weathering processes, predicted to be worsened by future climate change. Because not fully satisfying treatment currently exists against these weathering processes, the project will be aimed at multi-functionalizing a recently proposed biomimetic treatment based on hydroxyapatite (HAP), to make it able to tackle all the main marble degradation processes (sugaring, soiling, dissolution and bowing). This target requires a multi-disciplinary reserach activity, combining materials science, biomaterials, micro-mechanics, petrophysics and CH conservation. Such an approach will be possible by merging competences and laboratory facilities of the 3 involved Organizations: Princeton University (outgoing phase, supervisor Prof. G.W. Scherer and co-supervisor Prof. W.O. Soboyejo, world-renowned experts in materials science and micro-mechanics, respectively), the University of Göttingen (secondment, supervisor Prof. S. Siegesmund, international expert in marble deterioration) and the University of Bologna (return phase, supervisor Dr. E. Franzoni and co-supervisor Prof. N. Roveri, international experts in materials for CH conservation and HAP for bio-medical applications, respectively). Under the guidance of these experts, the Experienced Researcher (ER) will receive high-level training-through-research and will considerably deepen and diversify his knowledge, by also attending academic and training courses, thus developing a multi-disciplinary expertise. This new expertise and the publication of research resul