RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'eCO-friendly urban Multi-modal route PlAnning Services for Mobile uSers' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The demand for mobility of people and goods in urban environments steadily increases raising long-term sustainability, quality of life and environmental concerns. While ICTs have established the ground for developing intelligent transport services and applications, their effective use for supporting cleaner urban mobility still represents a major research challenge.eCOMPASS introduces new mobility concepts and establishes a methodological framework for route planning optimization following a holistic approach in addressing the environmental impact of urban mobility. eCOMPASS aims at delivering a comprehensive set of tools and services for end users to enable eco-awareness in urban multi-modal transportations. eCOMPASS involves a generic architecture that will consider all types and scenarios of human and goods mobility in urban environments minimizing their corresponding environmental impact. Firstly, the project will focus on the design and development of intelligent on-board and centralized vehicles' fleet management systems; the fundamental objective of eco-awareness will be addressed through employing intelligent traffic prediction and traffic balancing methods, while also taking into account driving behaviour and considering the option of car drivers transferred to means of public transportation at suitable locations. Secondly, eCOMPASS will develop web and mobile services providing multi-modal public transportation route planning, taking into account contextual information (such as location and time) as well as various restrictions and/or user constraints. Recommended routes will be optimized mainly in terms of the transports' environmental footprint, although additional objectives will also be considered. An important objective of eCOMPASS is to develop novel alg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Advanced laser sensor systems for leading edge manufacturing'.

assistant: **Innovation**

The proposal targets the development of novel sensors to achieve next generation product quality and process control levels. Optical sensors based on tuneable diode lasers in near infrared have clear advantages in many applications where for instance non-invasive, in-situ technique is required. It can also be the only industrial choice where reactive or corrosive gases are involved. Recent rapid developments in technologies critical to NIR-Diode Laser spectroscopy, mainly in the telecoms industry, and the emergence of potential new application areas have catalysed this proposal and hold out the potential for a step change in spectroscopic monitoring. Five promising applications have been first selected. The partnership is well balanced between equipment and technology developers and end users many having a large share in the market they operate in. 4 countries (incl. less favoured) and 5 innovative expanding SMEs are included.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'THE ROLE OF MUGINEIC ACID IN UPTAKE OF TRACE METALS IN PLANTS' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Zinc (Zn) deficiency in agricultural soils is leading worldwide to the production of stunted rice and to human malnutrition.Some rice varieties take up Zn even if it is present in soil in low bioavailable amount, but the underlying process is unknown.One mechanism proposed includes the secretion of organic ligands (i.e. deoxymugineic acid-DMA), its complexation with Zn in soil and the uptake of the complex into the plant. Indirect evidence comes from isotopes studies but the direct proof (i.e. measure DMA secretion in soil and DMA complexation with Zn in competition with other cations) is missing. To this end, we will determine the fluxes of DMA secreted by roots. The challenges are to develop an experimental system that reproduces Zn deficiency in laboratory and to develop analytical methods that enable the identification and determination of the mass fluxes of DMA. We propose to use pot and hydroponic experiments with different Zn supply. The Zn deficiency in the soil/solution, will allow us to predict the stimulation of DMA production. The latest generation of LC-MS/MS with hugely improved sensitivity will be used to quantify the concentrations of DMA and Zn-DMA complexes. Moreover, we will establish an accurate stability series for Zn and other cations complexing with DMA and we will determine the reaction mechanisms and structure of Zn with DMA. The stability series will address the question of whether competition by other cations prevents the formation of the Zn-DMA complex in soil. Understanding the reaction mechanisms of Zn with DMA and establishing its structure will give invaluable insights into the stability of the complexes. We will achieve this conducting carefully designed laboratory and theoretical chemistry experiments. A prompt application of this resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Multicomponent supramolecular wires as a platform for the control of protein functions'.

assistant: **Concept**

Supramolecular chemistry offers a platform on which it is possible to engineer modular systems to gain further understanding of complex biological phenomena. The goal of this proposal is to bring supramolecular systems to a more advanced level of complexity by merging synthetic supramolecular structures with engineered proteins and oligonucleotides to generate hybrid supramolecular systems. A program based in five stages is described, where all the systems make use of the inherent dynamic nature of hybrid supramolecular wires to dictate control over protein functions. These architectures are based on disc-shaped molecules that self-assemble to form supramolecular wires, while maintaining the ability to exchange monomers after initial assembly. A covalent approach will be established in stage one, engineered proteins will be covalently attached to the discotic building blocks of the supramolecular wire. Their assembly along the supramolecular wire will induce protein activity, e.g. protease activation. In stage two, short oligonucleotides covalently attached to the discotic building blocks and to the proteins, will provide additional control over the final assembly. The topic of stage three is the recruitment of signalling proteins in a reversible manner by displaying short peptide binding motifs for specific protein binding domains. For stage four, supramolecular wires will exhibit small oligonucleotides that will bind reversibly to protein fusion-oligonucleotide hybrid constructs resulting in protein activation and signal transduction. A higher level of complexity will be explored in stage five, by decorating the supramolecular wires with a larger array of responsive peptide and DNA motifs. This work will contribute new concepts, tools, and materials for elucidation an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Metabolomics of fungal diseases: a systems biology approach for biomarkers discovery and therapy' (FUNMETA), addressing dissemination and exploitation.

assistant: **Impact**

Humans have evolved intimate symbiotic relationships with a consortium of gut microbes (including fungi) and individual variations in the microbiome influence host health and disease. The fact that fungi are capable of colonizing almost every niche within the human body suggests that they must possess particular immune adaptation mechanisms, the breakdown of which may result in fatal fungal infections and severe fungal diseases. Traditional reductionist approaches of the past have not been sufficient to address these new challenges in the pathogenesis of fungal diseases. Here, I propose an integrated, systems biology approach to understand the role of L-tryptophan (trp) metabolic pathways in multilevel host−fungus interactions. Present in mammals as well as in fungi, pathways of trp metabolic pathways are exploited by the host and the fungal biota for survival and immune adaptation. A variety of indole derivatives, generated through conversion from dietary trp by symbiotic bacteria, activate the aryl hydrocarbon receptor/IL-22 pathway that provides antifungal resistance and tissue repair. Harmful inflammatory responses to fungi are instead tamed by kynurenines generated via the enzyme indoleamine 2,3–dioxygenase (IDO) of the trp pathway. Through high-throughput wet-lab ‘omics’ techniques combined with computational techniques, the project aims at defining the molecular basis of mammalian and fungal IDO activity and a metabolic network linking the metabolic phenotype (metabotype) to immune adaptations and its possible breakdown in experimental and human fungal infections. The project will provide ideal post-graduate training focussed on the development of metabolomics for diagnosis of fungal diseases and optimization of current antifungal therapy and diet that are of rel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European Biotechnologies Common Tools' under Seventh Framework.

assistant: **Concept**

This project deals with the necessity in the EU to build a system that enables entrepreneurs or academia Technology Transfer Offices to achieve, in the best conditions of rapidity and cost effectiveness, the Industrial Proof of Concept (I-PoC) that enables a real economic valorization of Research achievements (Scientific Proof of concept-Sci-PoC). This early stage development is considered world wide as the weak ring in the chain of innovation.The objective is to design a Joint Action Plan between Consortium members and other EU Bio-Regions, that will enable any actor responsible for an early stage development to beneficiate from a variety of shared resources that will accelerate the process, make it safer and cost effective.The central tool (WP4) for this is twofold: (1) A network of maturation systems that can take in charge the pre-development stage without creating a company. The existing examples are Go-Bio in Berlin, Bioline in Israel, and several systems in the US. (2) A network of Incubation systems that can, collectively, select, mentor, finance and nurture start-up companies, wherever they are located.The second common tool (WP5) to be built is a network of high grade facilities, where a large part of the technical experimentation of the maturation process could be done. The third tool (WP3) is probably the most valuable: Bio CT aim at building common tools for enabling maturation projects to find the personnel they need, through internal EU mobility or thanks to an attractive Reverse Brain Drain set of measures.The three tools will be linked in a Joint Action Plan designed in the form of a Business Plan in which the financing and Governance parameters will be particularly addressed. Such thinking cannot be done over all domains of Biotechnology. In this proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'A decision within a decision: Exploring the psychological, electrophysiological and computational mechanisms underlying changes of mind and metacognitive judgements.'.

assistant: **Innovation**

MetaChange is an original and innovative project combining large scale online psychophysics experiments, invasive electrophysiological recordings in epileptic patients and computational modeling in order to brush a comprehensive picture of the effect of post-decisional information on the cognitive and metacognitive components of decision making.The project will use a causal approach based on stimulus manipulation or direct brain stimulation to explore the effects of post-decisional information on these components of decision making, and assess how these effects unfold in time. We also aim at determining the neuronal mechanisms supporting decisional and post-decisional integration, as well as their link with metacognitive processes such as confidence ratings and changes of mind. Finally, we intend to develop a computational model of decision making rooted in evidence accumulation, accounting not only for response times and response accuracy but also for changes of mind and confidence ratings. Overall, MetaChange aims to address in an interdisciplinary and synthetic manner some of the current challenges in the field of decision making and metacognition.


**Keywords:** Decision-making, Metacognition, Evidence accumulation, Epilepsy, Invasive recordings, Electrical Stimulations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Personalised ICT-tools for the Active Engagement of Consumers Towards Sustainable Energy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Eco-Bot aims to utilize recent advances in chatbot tools and advanced signal processing (i.e. energy disaggregation) using low-resolution smart meter-type data with the goal of changing their behaviour towards energy efficiency. Eco-Bot targets to a personalized virtual energy assistant to deliver information on itemized (appliance-level) energy usage through a chat-bot tool.The ""chat-bot"" functionality will be use an attractive frontend interface, permitting seamless communication in a more natural and interactive way than a traditional mobile application. This way, Eco-Bot aims to achieve a higher level of engagement with consumers than previous efforts (i.e. serious games, gamification, competitions or other interactive ICT), by adding a more engaging form of interaction with existing platforms that has been proven in different market settings.The proposed system considers knowledge of the delivered multi-factorial models, including rebound-effects, as a result of the baseline research on both European and International activities. Then, based on advanced ICT, such as knowledge engineering, machine learning, expert systems, the project transforms the multi-factorial models for energy reduction to interactive, personalized and targeted recommendations to consumers on how to save energy.Eco-Bot uses also existing NILM, e.g. energy disaggregation methods, and data analytics to break down consumption to the appliance level, where this is possible (smart meters at reasonable granularity, adequate number of information collected) so as to make consumers aware of their most energy-consuming devices.The project will demonstrate the system in three different use cases, each one representing a different business model (B2B / B2B2C /B2C). We aim to validate our system across
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Training in electrical systems', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

There is an increasing push in Europe towards regulating safety procedures for the installation of domestic utilities. For instance, the European Committee for Electrotechnical Standardisation (CENELEC) issued a decree for the standardisation of all electrical installation work. All European countries have to conform to this standard since the end of 1996. This requires all practising electricians, technicians and inspectors to refresh and to bring up-to-date their background knowledge of inspecting existing installations and to adopt new procedures complying with the European standards. Training organisations are required to prepare new training programmes and to issue a diploma that will be a requisite for all registered electricians before they can undertake installation works, and the professional technical schools are asked to prepare the students to work as the new standardisation requires. This is a massive training initiative and one that requires a technological solution, to have any chance of being efficient and effective. The TEST project will develop and evaluate pilot applications of a Multimedia Intelligent Training System (MITS) for the training of domestic electrical installation procedures. The training application will be focused on a number of practical exercises that will assess the basic concepts and the level of expertise of the trainee. It will be a computer-based laboratory where the trainee will be asked to design schemes for solving a number of exercises following an increasing level of complexity. The system will include a graphical facility that allows the trainee to design the circuits according to data and constraints imposed by the exercise, and an on-line simulator to compute variable values and detect violations. The pilot application wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cellular and molecular analysis of the skeletal pathologies associated with mucopolysaccharidosis-VI (MPS-VI)' in the context of a Horizon 2020 call.

assistant: **Objectives**

Mucopolysaccharidosis-VI (MPS-VI) is a lysosomal storage disorder predominantly affecting skeletal remodelling and caused by pathogenic mutations in the ARSB gene, encoding the glycosaminoglycan-degrading enzyme arylsulfatase B. Preliminary analysis of Arsb-deficient mice unraveled a skeletal phenotype of similar severity and with lysosomal storage defects in different skeletal cell types. This Arsb-deficient mouse model therefore provides an excellent tool to understand the skeletal and non-skeletal pathologies related to MPS-VI and to address the clinically relevant question, if enzyme replacement therapy (ERT) can influence the existing (non-)skeletal pathologies in lysosomal storage disorders. Moreover, another major objective is to unravel the cellular consequences of Arsb-deficiency on a molecular level and to investigate mechanisms of ARSB uptake and lysosomal delivery in different primary cell types of Arsb-deficient mice. This project will therefore certainly generate knowledge with relevance for other (skeletal) disorders as well, as the cellular defects in MPS-VI are closely linked to that of two of the most prevalent disorders in the European Union, i.e. osteoporosis and osteoarthritis. Next to its scientific goals, this proposal aims to offer a broad personal training program for me as a postdoctoral researcher as well. Handling this project will not only offer an intensive scientific training (intellectual-methodological), but also improve my skills regarding project management (administrative-financial) and writing. As a two-way transfer, my previously acquired knowledge on the genetics of skeletal disorders and related experimental skills will be transferred to the host organization. A final goal of this proposal is to disseminate the acquired data towar