RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'UROthelial carcinoma Biomarker based diagnostic tEST'.

assistant: **Innovation**

Bladder cancer is among the five most common malignancies worldwide: more than 380.000 new cases are diagnosed yearly. If detected early, 5-year survival is high (94%),but >70% of diagnosed patients will relapse within this period. The current gold standard diagnostic tool is combined cytology and cystoscopy which is costly and highly invasive requiring transurethral access and presenting the risk of important complications. Due to high relapse rates, surveillance requires frequent cystoscopies, averaging 13 controls per patient after initial diagnosis. Hence, bladder cancer is one of the costliest cancers to treat and monitor. Only in the USA, Europe and Japan, more than 4.5 million cystoscopies are conducted yearly, 40% for 1st diagnosis and 60% for surveillance, at a cost near to $2 billion to healthcare providers.Urologists believe that an opportunity exists to reduce the number of SURVEILLANCE cystoscopies with a reliable, cost-effective, robust, easy-to-perfom and non-invasive assay. URO-BEST addresses this unmet need. Based on signatures of 2, 5,10 and 12 differentially-expressed genes, this test has been clinically validated in a multicenter international study on 525 urine samples demonstrating 81% sensitivity and 91% specificity in discriminating cases vs. healhty patients for first diagnosis, figures comparable to that of the gold standard and superior to other existing molecular diagnostic products (Urovysion, NMP22, BTA Stat). We estimate the current market for bladder cancer biomarker based tests at greater than > $200million. Fina Biotech has filed European and PCT patent applications protecting the invention in 2013.Fina Biotech aims to clinically validate the diagnostic performance of the genetic signatures in patients under SURVEILLANCE for its launch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Highly Automated Vehicles for Intelligent Transport' in the context of a Seventh Framework call.

assistant: **Objectives**

The path-breaking HAVEit proposal aims at the long-term vision of highly automated driving. Within this proposal important intermediate steps will be developed, validated and demonstrated. These intermediate results on the one hand offer high potential for exploitation within 3-5 years after HAVEit and on the other hand form the ideal basis to integrate further next generation ADAS (highly automated functionalities) by adding software modules.<br/>HAVEit will significantly contribute to higher traffic safety and efficiency for both passenger cars and trucks, thereby strongly promoting safe and intelligent mobility of both people and goods. The strong HAVEit safety and efficiency impact will be generated by three measures:<br/>(i) By optimizing the task repartition between driver and co-driving system (ADAS) in the joint system. As 95% of all accidents are caused by driver mistakes, it is very important to ensure the driver is in the loop when required to make sure he or she is able to react properly in a potentially critical situation. Within HAVEit a radically new approach will be developed: Instead of just switching off an ADAS system in case of an impending potentially critical situation, a step-by-step-approach will be used to transfer the driving task back from the automated system to the driver. <br/>(ii) By further developing and implementing the failure tolerant, safe vehicle architecture including advanced redundancy management (from the SPARC predecessor project) to suit the needs of highly automated vehicle applications and to arrive at higher system availability and reliability.<br/>(iii) By developing and validating next generation ADAS directed towards higher level of automation compared to the current state of the art: HAVEit integrates 7 cutting edge hig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Gut Symbiomes of Fungus-growing Ants' (GUTS) targeting Seventh Framework.

assistant: **Abstract**

Symbiosis is the close and long-term interaction between different biological species. Insects are among the best model systems for studying symbioses as their immune systems appear to be relatively tolerant to invasion and their niches are often so specialized that microbial symbionts can satisfy important metabolic needs. Laboratories across the world often specialize either in the molecular biology of host-symbiont interactions in specific insect models, or in the evolutionary biology of parasitic or mutualistic symbioses taking a broader approach. This proposal is meant to build bridges between these domains, by applying advanced molecular methods to resolve fundamental evolutionary questions of symbiosis in a social insect model system. My research will focus on an almost completely unknown component of the symbiosis between attine ants and their fungus-gardens: the bacterial communities in the guts of these ants that likely fulfill complementary roles in the symbiosis. Objectives are to identify these bacteria, to localize them when they are tissue-specific, and to compare their functional roles across several attine genera that represent different stages of advancement of the symbiosis. I will use qPCR, FISH and TEM to identify putative symbionts, metatranscriptomic techniques to characterize the cumulative bacterial genes that are expressed in the ant guts, and qRT-PCR and RNAi to clarify some of the functional roles of ant and microbial genes that are expressed in the guts. The research that I propose is highly multi-disciplinary, as it combines a wide range of state-of-the-art molecular techniques with conceptual hypotheses from social evolution theory. This combination is feasible because my training in molecular microbiology of fruit-fly and aphid symbionts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Design and test of the piafe fission source' in the context of a Fourth Framework call.

assistant: **Objectives**

Radioactive Ion Beams (RIB) are of increasing interest and importance, not only for nuclear physics, but also for astrophysics, nuclear chemistry and solid state physics. PIAFE, the Grenoble project for radioactive ion beams, will be able to provide very intense - probably the most intense - beams of neutron-rich nuclei due to the unique combination of a high-flux reactor (ILL) and a heavy-ion accelerator (ISN), both aleady existing on adjacent sites. During my work on the PIAFE project in the last ten months, I was strongly involved in the design of the ion source. The project design and test of the PIASE fission sources aims at verifying important characteristics of the foreseen materials, as well as the expected behaviour of the complete source. Especially it must be proven that the source meets rigorous safety requirements, as it willbe located in a beam tube of the ILL reactor. It is therefore planned to simulate the operating conditions of the source as closely as possible. The necessary equipment exists already at ILL and will be ready for use after some adaptions. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'An augmented intelligence-enabled stimulating framework for deep energy renovation delivering occupant-centered innovations' to be submitted under Horizon 2020.

assistant: **Abstract**

RINNO envisions to deliver a framework solution that will help drastically accelerating the rate of deep renovation in EU building stock reaching an ambitious annual renovation rate of 3.5%. Its ultimate goal is to develop, validate and demonstrate an operational interface with augmented intelligence and an occupant-centered approach that will streamline and facilitate the whole lifecycle of building renovation (planning-design, retrofitting, monitoring). This concept has at its foundation, a set of cost-attractive, environmentally friendly, multi-functional and easily applicable building-related innovations, grouped into: a) plug-n-play, modular building envelope solutions and b) RES, hybrid and storage solutions. RINNO couples the above with innovative retrofitting processes, methods and tools, characterized by low tenants’ disruption. These comprise: efficient (off/on-site) construction strategies, on-the-job AR facilitating environment and multi-stakeholder collaboration, which are expected to shrink the time and cost required for deep renovation, while improving buildings’ performance; all with a short payback period of about 5 years. The above will be supported businesswise with novel business models aligned with the circular economy principles, enriched with investment de-risking tools and advanced crowd-equity/crowd-lending schemes. RINNO is expected to impact the EU inefficient building stock by a) reaching an ambitious annual renovation rate of 3.5%; b) primary energy savings of 165 GWh/year; c) a reduction of electricity cost by at least 30%; d) a total cost / time reduction in comparison with typical renovation by more than 30% and 40% respectively, and e) an estimated reduction of 40,400 tons CO2-eq/year. RINNO optimized renovation roadmap will be demonstra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Atlas reconstruction software and data analysis' to be submitted under Sixth Framework.

assistant: **Abstract**

ATLAS is one of the experiments of the future accelerator LHC (Large Hadron Collider) at CERN, which is expected to start working in 2007. The project will be focused on the commissioning of the ATLAS Inner Detector reconstruction software in order to be fully functional for the first proton collisions and on the preparations for the physics analysis of the first data taken by the detector.The commissioning will be done in different phases: cosmic rays at the surface with different Inner Detector setups, cosmic rays in the ATLAS cavern, single beam and first proton-proton collisions. The first phase will be essential for the consolidation of the reconstruction chain including the calibration and alignment procedures.The events recorded in the following phases will be used to provide the first alignment and calibration constants. Concerning the physics analysis, the project has two objectives: first the development of b jet tagging algorithms optimal for high transverse momentum jets. And second, the study of the characteristics of the top quarks of high transverse momentum.Thanks to the experience of the researcher in the Inner Detector reconstruction acquired as Marie Curie fellow at CERN and her expertise on b tagging and physics analysis from her DELPHI period, a group of experts on the objectives of this project can be formed in the host institute. At the same time, the possession of an individual project by the researcher will turn out to be crucial for the professional integration and long-tern jobs stability of the researcher.In order to ensure the success of this project a close collaboration with the rest of the ATLAS groups is essential. In particular it is important to be in contact with the detector and data acquisition experts during the data taken periods
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of fully synthetic bio-inspired extracellular vesicles for regenerative wound healing' (SYNERGY), addressing dissemination and exploitation.

assistant: **Impact**

Wound care constitutes a growing clinical and economic burden, with the global market predicted to exceed €28.6B annually by the end of 2024. This represents a 71% increase in wound prevalence and a 48% increase in management cost in the last decade. Despite advances in our understanding of the cellular and molecular mechanisms involved in wound healing, the rapid growth of these markets alone underlines the need for new therapeutic approaches to address the growing incidence of chronic and non-healing wounds and the ongoing development of scar tissue and fibrosis -which increase the risk of severe complications, significantly impact patient quality of life, and extend the burden on healthcare systems. Extracellular vesicles (EVs) from mesenchymal stromal cells (MSCs) and MSC-like cells, have already been proven to significantly enhance wound healing and inhibit scar formation. Despite their potential, the inherent complexity, source-based variability of these cell-based therapies, as well as a lack of conclusive information regarding their mechanisms of action, has significantly impeded their clinical translation. This proposal outlines the characterization of natural EVs from both novel and established MSC sources; the identification of key biological and biophysical factors underpinning their potential to support wound healing and reduce fibrosis; and the application of this knowledge to design, optimize, and validate bio-inspired fully synthetic extracellular vesicles (fsEVs) as a novel treatment to improve clinical wound healing outcomes.


**Keywords:** Synthetic Biology, Bio-inspired, mesenchymal stem, stromal cells, MSCs, Extracellular Vesicles, Wound Healing, Tissue regeneration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dynamically defined fractals with overlapping constructions' (2002-2006).

assistant: **Concept**

Since the seventies there has been a growing interest in different branches of the sciences (including physics, chemistry, biology, finance, etc.) about a new phenomenon called fractals''. As a result of this, since the mid-eighties mathematicians have been investigating the structure of fractal sets. The simplest fractals are the so called self similar ones. These are fractals which are unions of their own similar copies (I.e., scaled down versions of the original). These similar copies (so called cylinders) may be pair wise disjoint. This is the easy case, which has been well understood since mid eighties. However, there may be significant overlapping between the cylinders. This latter case is much more problematic to analyse. The first result in hand ling this more difficult case was due to Falconer 1988. Inspired by that work, M. Pollicott and K. Simon (the host and the researcher of this project, respectively) worked out a method which is nowadays called applying the "transversality conditions. In f act, this is the only known method to give a good understanding of a typical member of a one parameter family of fractals of overlapping construction.. The aim of our project is to develop new and more effective tools to handle fractals arising from such overlapping constructions. Such fractals naturally occur in many important physical models. To achieve this aim we investigate four major cases: The Hausdorff dimension of the fat Sierpinski triangle, The Fourier transform of self-similar measures for an overlapping construction, IFS which are contracting on average, Fractals of overlapping construction used in fractal image recognition. These problems are explained in detail in the "Project objectives''. To solve any of these specific problems will require the inventio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Shine a Light on Villa Adriana. Analysing and reconstructing the original lighting asset and the illumination design process of the architectural complex of Villa Adriana, Tivoli.'.

assistant: **Concept**

The fellowship will be carried out in the Archaeology Area of the Department of Geography, History and Philosophy of the Pablo de Olavide University of Seville, with the supervision of Prof. Hidalgo Prieto. The project aims at analyzing and reconstructing the original lighting asset and the illumination design process of the outstanding architectural complex of Villa Adriana in Tivoli, Italy. Built under Hadrian’s reign, it counts more than 30 major building complexes. Given its importance and its good state of preservation the site has been studied in all aspects but the theme of light has remained neglected. Thanks to my background skills, new technologies for surveying, georeferencing, 3D reconstruction, virtual light reproduction, and thanks to the synergy among archaeologists, architects, IT experts, historians of science, lighting engineers, I will be able to approach this topic in a systematic way, addressing the technical and stylistic aspects of the lighting design praxis in its whole. The project will focus on three case-studies selected for their different features, functions and requirements: the triclinia halls, the Baths buildings, and the Praetorium complex. Their archeological remains will be surveyed with cutting edge technologies to gather accurate data, examined in relation to their context and imagined in their elevations through digital reconstructive models to investigate and reconstruct their original luminous ambiences. Though a secondment at the School of Specialization in Archaeological Heritage of Sapienza University of Rome and at Biblioteca Hertziana Visualizing Science in Media Revolution Research I will address the aspects related to lighting engineering and history of science. To verify, perfect and communicate the results achieved I will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Automatic 3d scanning for design and inspection using non-contact sensors' in the context of a Fifth Framework call.

assistant: **Objectives**

In this project we propose that rapid physical non-contact inspection which produces dense point clouds , point cloud surfacing tools , and point cloud to CAD inspection tools are necessary techniques within the modern mechanical design process. We intend to adapt existing well proven non=contact technology so that it can be utilized by the large base of existing positioning systems, this will be achieved through the development of common interfaces using common open standards. To further improve productivity intelligent scanning algorithms will be developed to fully automate the scanning procedure.The automation of the scanning process will allow manufacturing industry to decrease:(l) the human operator intervention in the measurement process by 90%;( 2) the product development times by 50%,(3) the design costs, by 50%, and the time taken to inspect manufactured parts by 60%:' Moreover' it allows largely increasing the design quality and the build quality and the build quality of manufactured parts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tightening knowledge sharing in distributed software communities by applying semantic technologies' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The TEAM project addresses the need for a knowledge sharing environment with advanced capabilities suitable for the distributed engineering and management of software systems.The TEAM project aims to develop an open-source software system, seamlessly integrated in a software development environment for enabling decentralised, personalised and context-aware knowledge sharing through:-Knowledge Desktop, a component embedded in the software development environment that provides a graphical interface for knowledge manipulation, as well as an integration platform for other knowledge sharing component-Context Observer, a component that enables capturing a software developer's behaviour in his desktop environment (i.e. context elicitation), its analysis (i.e. context processing), as well as triggering the knowledge manipulation mechanism (i.e. knowledge acquisition and delivery)-History Analyser, a component that enables elicitation of a software developer's profile from his previous behaviour-Semantic Search, a component that supports context-aware ontology-based proximity search for relevant knowledge items-Semantic Recommendation, a component that enables proactive knowledge delivery depending on the actual working and personal context of the user-Metadata repository that enables efficient structuring and persistent storage of the acquired knowledge, as well as reasoning about its completeness and consistency,-P2P Infrastructure for decentralised communication between local Knowledge Desktops of software developers.