RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'a Theoretical chemistry Approach to tiME-resolved molecular Plasmonics' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Ultrafast spectroscopy is a powerful tool able to disclose the atomistic real-time motion picture of the basic chemical events behind technology and Life, such as catalytic reactions or photosynthetic light harvesting. Nowadays, by cleverly harnessing the interaction of the studied molecules with plasmons (collective electron excitations supported, e.g., by metal nanoparticles) it is becoming possible to focus these investigations on specific nanoscopic regions, such as a portion of a catalytic surface or of a photosynthetic membrane. This coupling can also produce new quantum effects such as molecule-plasmon hybrid excitations. On the other hand, it makes the real-time molecular evolution and its perturbation by light more complex, and thus calls for new theoretical treatments. The available ones are unable to tackle this complexity, because they consist of phenomenological models focused on field enhancements or on generic features of the various plasmon-molecule coupling regimes. The goal of TAME-Plasmons is to develop a theoretical chemistry approach to directly simulate the real time evolution of molecules interacting with plasmons and light. Our approach lifts the current theoretical limitations by coupling a real-time quantum chemical description of the molecules with a time-dependent electromagnetic description of plasmons, rooted in our previous work on steady-state molecular plasmonics. We will implement this approach in an open-source software, accessible also to non-specialists. We will address current open issues such as the controversial nature of plasmon-aided frequency up-conversion by noble gases and the interpretation of sub-molecularly resolved photoemission induced by scanning tunneling microscopy. We will also anticipate questions that may arise alo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'New Target and Drug Candidates for Alleviating Chronic Pain' (ChronicPain) under Horizon 2020.

assistant: **Objectives**

Chronic pain is one of the most significant unmet medical needs and health burdens in society today. This is due to limited analgesic efficacy of existing drugs, coupled with adverse side effects, and the development of tolerance over time. Moreover, patients may develop dependence on commonly prescribed opiate-based analgesics, with negative consequences and greatly increased societal costs. Hence there is a pressing need for new targets for drug development and new drug candidates to target chronic pain.During the course of our recently completed ERC grant we screened a number of mouse mutants for sensory neuron phenotypes that might arise from perturbation of neuron growth control mechanisms. We discovered an unexpected phenotype of reduced pain sensitivity in an importin knockout mouse line. Most strikingly, acute knockdown of this specific importin gene had an ameliorating effect in the chronic stage of a neuropathic pain model. Screening for drugs that might mimic this effect lead to the identification of a number of approved drugs that are candidates for repositioning as analgesics.In this PoC we will carry out the following objectives: (1) file for IP protection on the new pain drug target and the initially identified candidate analgesics; (2) validate the new drug target and drug candidates in models of neuropathic and/or chemotherapy-induced chronic pain; (3) devise an HTS-compatible assay for future screening of additional drug leads for chronic pain; and (4) carry out additional IP protection and pre-clinical validation steps to maximize the commercialization potential of this discovery.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Studies on mechanisms involved in the establishment and breakdown of t-cell tolerance using t-cell receptor transgenic mice' (1994-1998).

assistant: **Innovation**

We propose to study molecular mechanisms underlying T cell tolerance induction and its breakdown by bacterial superantigens. We are using transgenic mice (F5) expressing a T Cell Receptor (TCR) specific for the nucleoprotein (NP) of the influenza virus crossed to mice expressing ubiquitously the NP antigen. F5/NP doubly transgenic mice in the RAG1 / background develop only anergic T cells. Those can be reactivated and acquire cytotoxic effector functionin vivo by administration of the bacterial superantigen Staphylococcal Enterotoxin A (SEA). We will a) attempt to define conditions at which reactivated T cells can lead to autoimmunity in these mice; b) study the role of TNFx in T cell tolerance and activation in F5 and F5/NP mice by crossing them to TNFx / mice and challenge them with antigenic NP peptide and SEA; c) identify and characterise genes involved in T cell tolerance using an improved version of the mRNA differential display technology. Our studies will improve the understanding of detrimental immune responses and could help in the development of strategies for clinical interventions in humans. Training content (objective, benefit and expected impact) Our goal is to better understand molecular and cellular mechanisms of establishment of T-cell tolerance and its breakdown. These studies will contribute to the development of new tools and strategies for prevention and intervention in autoimmune disorders. The projects we developp and the technics we use are improving my technical and fundamental knowledge in the field of immunology. An E.C. fellowship would give me thepossibility both to finish already promissing research projects and to accomplish my PhD thesis in a E. C. foreign country.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'CRICKET INSPIRED PERCEPTION AND AUTONOMOUS DECISION AUTOMATA' (CICADA) under Fifth Framework.

assistant: **Objectives**

By combining transdisciplinary knowledge ranging from sensory ecology to microtechnology, we will transfer knowledge from the sensing-perception-action mechanisms in insects escaping danger to the development of highly integrated artificial life-like miniature systems based on MEMS and Bio-Electronic technologies. Due to their unmatched sensitivity at the receptor level and the high speed of reaction, we will concentrate on the air currents perception and escape action arising from mechanoreceptor hairs of crickets, which respond to attacking predators. The degree of information redundancy from many hairs and the minimal configuration in crickets will be used to design large arrays of MEMS sensors. As an acid test, we will build a miniature demonstrator. By combining transdisciplinary knowledge ranging from sensory ecology to microtechnology, we will transfer knowledge from the sensing-perception-action mechanisms in insects escaping danger to the development of highly integrated artificial life-like miniature systems based on MEMS and Bio-Electronic technologies. Due to their unmatched sensitivity at the receptor level and the high speed of reaction, we will concentrate on the air currents perception and escape action arising from mechanoreceptor hairs of crickets, which respond to attacking predators. The degree of information redundancy from many hairs and the minimal configuration in crickets will be used to design large arrays of MEMS sensors. As an acid test, we will build a miniature demonstrator.OBJECTIVESIncrease significantly the advancements of biomimetic life-like perception systems by providing novel data and concepts on a 'sensing-perception-action' chain. The specific objectives are the integration of knowledge from the biological paradigm (the flow of in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'CELL THERAPY EMPLOYING ENDOTHELIAL PROGENITORS FOR EXPERIMENTALLY INDUCED CARDIAC ISCHEMIA'.

assistant: **Concept**

Introduction: Transdifferentiation of umbilical cord (UC) blood, bone marrow (BM) and vessel derived stem cells into endothelial progenitors has been reported both in vitro and in vivo. Encouraging but limited success with these studies suggested the need for identification of more versatile populations of endothelial progenitors or signaling pathways to improve their homing to ischemic sites seeking angiogenesis and neovascularization. Objective: We propose to isolate and characterize in vitro endothelial progenitors derived from BM, placental vessels, and UC blood/matrix and to investigate whether successful in vivo endothelial regeneration, differentiation and maintenance can be achieved by systemic delivery when a defined demand is placed on the endothelium. Next, we propose to investigate whether endothelial progenitors homing to ischemic sites can be enhanced by delivery of chemoatractant molecules into the ischemic bed. Materials and methods: BM, placental vessel, and UC blood/matrix derived stem cell subpopulations will be assessed in clonal growth assays under conditions that promote endothelial commitment, and molecularly characterized for the expression of molecules and genes associated with endothelial lineage. The capacity of these cells to participate in vascular regeneration will be examined following systemic delivery into immunodeficient NOD/SCID mice with experimentally induced cardiac ischemia. Various chemokines will be investigated for their ability to augment endothelial progenitors homing to ischemic sites and to promote endothelial regeneration. Endothelial progenitors contribution to vascular reconstitution will be assessed by histology, immunohistochemistry, electron microscopy and clonal analyses of ischemic tissue samples. Relevance: The prop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The impact of flight experiences on the psychological wellbeing of unaccompanied refugee minors' (CHILDMOVE), addressing dissemination and exploitation.

assistant: **Impact**

Since early 2015, the media continuously confront us with images of refugee children drowning in the Mediterranean, surviving in appalling conditions in camps or walking across Europe. Within this group of fleeing children, a considerable number is travelling without parents, the unaccompanied refugee minors. While the media images testify to these flight experiences and their possible huge impact on unaccompanied minors’ wellbeing, there has been no systematic research to fully capture these experiences, nor their mental health impact. Equally, no evidence exists on whether the emotional impact of these flight experiences should be differentiated from the impact of the traumatic events these minors endured in their home country or from the daily stressors in the country of settlement. This project aims to fundamentally increase our knowledge of the impact of experiences during the flight in relation to past trauma and current stressors. To achieve this aim, it is essential to set up a longitudinal follow-up of a large group of unaccompanied refugee minors, whereby our study starts from different transit countries, crosses several European countries, and uses innovative methodological and mixed-methods approaches. I will hereby not only document the psychological impact these flight experiences may have, but also the way in which care and reception structures for unaccompanied minors in both transit and settlement countries can contribute to reducing this mental health impact. This proposal will fundamentally change the field of migration studies, by introducing a whole new area of study and novel methodological approaches to study these themes. Moreover, other fields, such as trauma studies, will be directly informed by the project, as also clinical, educational and so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'StartInnShop - Startup Innovation goes to market'.

assistant: **Innovation**

StartInnShop intends to reshape, through the Twinning Advanced methodology, a set of services to support early stage innovative startups in developing the right products to enter and (most important) remain in the market. When accessing a support service dedicated to explore market opportunities, beneficiaries most often receive a complete theoretical support, but the majority of programs that are available now lack of practical experiences to allow entrepreneurs to really test their idea. By matching the Lean methodological approach with a concrete market gateway - the “NeoShop”, an innovation boutique providing soft commercial launch for innovative products - StartInnShop aims to design a modular kit of tools and services for accompanying innovative, knowledge-based and creative startups in testing, improving and selling their products. The consortium is composed by three Innovation Agencies: Aster (Italy)- the project coordinator, Laval Mayenne Technopole (France) and The Rubicon Centre (Ireland), which have already worked fruitfully together. This twinning action has a multiple goal: allow partners to carry on a peer review and assessment on their respective services; reshape and combine those linked to market development and set up permanent relations within the partnership, who already exchanged information on their best practices, with the aim of improving each partners’ services and internationalization perspectives. The final aim of the project is the drafting of a complete Design Option Paper, dedicated to analyse and describe all different scenarios in terms of background, soft and hard infrastructures, sector and stage of development in which the service could be implemented  in order to facilitate its transfer and mainstreaming in the different EU contexts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Use of a hill cap cloud to study cloud aerosol interactions in ACE-2' under Fourth Framework.

assistant: **Concept**

To determine the radiative forcing of anthropogenic aerosols advected over the sub-tropical North Atlantic through the study of the transformation of the aerosol size distribution, chemical composition and hygroscopicThe project is part of the European contribution to the second Aerosol Characterisation Experiment (ACE-2)  of the International Global Atmospheric Chemistry Project (IGAC). ACE-2 and the connection with the other  projects has been discussed at several open planning meetings, and is described in the science and  implementation plan.  The specific tasks are:  1. To investigate the relationship between the cloud droplet size distribution and the chemical composition, size distribution and hygroscopic properties of the aerosol entering the cloud.  2. To investigate the nucleation scavenging of aerosol as it enters the cloud, as a function of particle size and chemistry.  3. The effect of aqueous phase cloud chemistry, including the oxidation of S(IV), the production of nitrate ions, the solution of soluble trace gases on the size distribution, chemical composition and hygroscopic properties of the aerosol.  4. To investigate possible processes producing new ultra fine particles by gas to particle conversion near cloud.  5. To investigate the interaction of DMS and its oxidation products with cloud.  6. To study the effects of the entrainment of free tropospheric air through cloud top on each of the above.  Using a ground based system of this kind it will be possible to make detailed continuous measurements of the  atmospheric trace gases entering and leaving the cloud.  Flights will be made using the UK Meteorological Office C-130 aircraft to make profiles of the thermodynamic  and trace gas constituents of the atmosphere over the sea upwind of the island and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Culture, Heritage and Identities: Impacts of Climate Change in North West Europe' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

CHICC aims to understand the impact of climate-change driven heritage loss on local communities. The widespread impacts of climate change are acknowledged in the UN’s Sustainable Development Goal 13: Climate Action; however, the full scale of the impacts on heritage and associated communities is currently unknown but knowable. Three damaged or lost heritage sites will be explored through CHICC: Mårup, Denmark; Dunbeag, Ireland; Brora, Scotland. Each has been altered by climate change, creating an impact on the lives and livelihoods of local communities, their sense of place and belonging, their perception of climate change; overall, impacting their cultural identities. As North-West Europe is expected to experience greater and more widespread heritage loss due to climate change, CHICC will use these sites to understand the complexity of loss, and the impact on communities and their cultural identities.Through adopting a Citizen Science approach, CHICC will include the often-omitted voice of local communities to understand how climate change impacts them, which may include an upsurge in engagement with climate change mitigation, greater energy for preservation or forgetting. Communities will be active participants within the research, contributing their views, ideas and resources. Through co-creation, CHICC will launch an online, deepmap for three damaged or lost heritage sites. The deepmap will collate and democratise multidisciplinary, primary and secondary data to interrogate the relationship between climate change, heritage and culture. This open-access resource will be created in-line with a Digital Preservation Strategy to ensure reuse of data for future researchers and varied stakeholder groups. The methodology developed includes co-creation and Citizen Science, u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Risk, Stem Cells and Tissue Kinetics – Ionising Radiation' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The magnitude of cancer risk in humans exposed to low radiation doses (<100mSv) is uncertain and depends upon extrapolation of human population based estimates obtained at higher doses.  The linear non-threshold extrapolation model currently used has some support from mechanistic/biophysical considerations but it is not based on understanding of the biological responses of the cells of origin for radiation cancer.  Stem cells are widely recognised as the cells of origin for many cancers.  Understanding the responses of stem cells to low radiation doses will be important therefore in providing mechanistic support for low dose cancer risk extrapolation.  In this project, techniques emerging  from stem cell biological and tissue kinetics research will be used to address several major areas of uncertainty in low dose (<100 mGy) cancer risk estimates:1.The identification and enumeration of stem/progenitor cells at risk2.Understanding low dose radio-sensitivity of stem cells and tissues.3.Improving understanding of mechanisms of age-dependant cancer risk4.Improving understanding of tissue specific differences in cancer risk.5.Identification of key events and individual susceptibility factors associated with cancer development.The primary output of the RISK-IR project will be peer reviewed scientific papers.  Considerable efforts will be made to consolidate scientific evidence of relevance for radiation protection through reviews and dissemination of project results and implications to radiation protection specialists will be facilitated through a stakeholder meeting in the final year of the project.