RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Simulation of droplets in complex microchannels' under Seventh Framework.

assistant: **Concept**

In droplet-based microfluidics, the elementary units transporting reagents from one functional site to another (mixer, sensor or analyzer) are droplets, which are carried by an inert wetting fluid. This research project aims at the development of numerical models of flowing droplets in thin spatially extended microchannels, designed at avoiding the exponential complexity of parallelized 1-D networks. We aim at simulating the trajectory of droplets transported by a pressure-driven carrier fluid, as they evolve in a surface energy gradient, generated by channel depth variations or surface tension inhomogeneities.To this end, we exploit the remarkable aspect ratio of these microfluidic devices to propose a depth-averaged description of the pancake shaped droplets. The resulting equations, called Brinkman's equations, combine the 2D Stokes equations with 2D Darcy potential-flow-like equations. Their diphasic simulation relies on the adaptation of existing algorithms to this particular free interface problem. Pressure corrections due to the thickness variations of the lubricating thin films will also be included.Surfactant and heat dynamics will then be added to model thermo- and soluto-capillary forcing. The depth-averaged model will be finally generalized to account for arbitrary depth variations, so as to add dynamics to the quasi-static description of droplets moving along successive minimal surface energy locations.A specific part of the project is also devoted to the development of an experimental expertise: it is indeed essential to the success of the project to conduct fundamental microfluidic experiments in order to validate our new models. While SIMCOMICS aims at shrinking the gap between present computations of droplets flowing in microchannels and the increasing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Economical exploitation of polymer coated steel sheet in large-scale production of new can types by the European can industry' in the context of a Sixth Framework call.

assistant: **Objectives**

The requirement to innovate in terms of new composite materials responds to increasing consumer demands for attractive and differentiated packaging in the food and beverage sectors. To this end, the project seeks to develop polymer coated steel sheet systems and design new container configurations, together with appropriate industrially applicable forming processes, to allow steel based containers to compete more effectively with alternative systems. The commercial advantages offered by the use of coated sheet material include the elimination of washing and lacquering operations with both cost and environmental advantages, highly adaptive formability and shaping properties, resistance to a wide range of fillings and external corrosion, as well as excellent shelf presence. It is widely recognised that there are strong environmental arguments in favour of steel for packaging. Firstly, all steel packaging (including coated products) is fully recyclable and in terms of consumer health issues, the advantages of steel cans for tamper-proof and safe long-term storage of foods and beverages are well proven and universal in European societies. The objectives of the work programme are to utilise and further develop existing experimental and computational instruments and expertise available to the partners in order to provide the knowledge necessary forth can making industry to develop large-scale production processes for attractive and novel can designs manufactured from both existing and new types of polymer coated sheet stock. The main project output will take the form of a body of research knowledge based on validated computational decision support instruments and experimental test data, complemented by the results of validation of the industrial prototype forming of polymer c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Demonstration of the Next Generation Wave Energy Device – POWERMODULE' under Horizon 2020.

assistant: **Concept**

Wello has developed and patented a concept which is able to convert the movement of waves into electric energy withoutany hydraulic joints and gears. The idea of Wello’s Power Module innovation is to combine vessel stabilization, damping andpower production into one electro-mechanical device. This is achieved by installing Power Modules to the ship and otherfloating vessels. Power Modules are optimized either for providing energy to the process or for stabilizing the vesselmovement. The difference between working principle is done by configuring user software and in some cases bydimensions. In Wello’s Power Module, the power take-off unit (PTO), consists of an eccentric spinning mass that rotatesaround the vertical generator axis. The innovation has been developed in small and full scale in EMEC (European MarineEnergy Centre) at Orkney Islands during last several years.The clients of this innovation are cruise liner and other ship owners and operators, offshore oil&gas field operators as well asemerging small scale offshore power users like fish farms, desalination process stations, algae cultivation and remote islandsystems. The market size is several billion Euros. Stabilization for vessels is needed for health and safety reasons.Renewable energy replacing CO2 emissions and other pollution at vessels.Objective of this project is to demonstrate the concept in full scale and in operational environment, and to create fullproduction capability. Outcome of this project is 300kW ocean energy generator. It can be installed into different vessel typesand it produces stable electricity always when there are waves.Wello will make ocean energy feasible by offering a cost effective solution that is able to provide renewable energy atcompetitive cost. It offers stabilization and d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular Imaging of Microglia' (MIM) under Horizon 2020.

assistant: **Objectives**

The societal burden of brain disorders, such as multiple sclerosis (MS), Alzheimer’s and Parkinson’s disease is enormous and is considered one of the world’s most important health challenges. They affect millions of people worldwide and the annual healthcare costs are high and are increasing with the aging population. There is an immediate need to better understand the underlying molecular mechanisms of these disorders. Particularly, the important role of the brain-specific immune cells called microglia needs to be unravelled. Microglia become activated upon inflammation in the brain and its activation covers a wide spectrum of activation states, ranging from stimulating the inflammation (pro-inflammatory status) to reducing the inflammation (anti-inflammatory status). To fill the current knowledge gaps regarding the role and regulation of the different activation states of microglia, I will use positron emission tomography (PET) imaging. My host institution has recently succeeded in developing a PET tracer for imaging pro-inflammatory microglia. However, there is no complementary tracer existing for selective imaging of the anti-inflammatory status. In the proposed project, I will develop a PET tracer targeting the P2Y12 receptor, a receptor over-expressed on anti-inflammatory microglia. To achieve this, I will use an interdisciplinary approach spanning from computational medicinal chemistry through synthetic organic chemistry and radiochemistry to in vitro and eventually in vivo evaluation studies in an animal model for MS. A successful PET tracer will find widespread application in the research regarding brain disorders and ultimately guide drug development and treatment opportunities. On a personal level, the proposed project will have a substantial impact on my car
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Analysis of structure-borne using spatial statistical distributions' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content Within the area of structural dynamics a fundamental problem is the prediction of sound levels with a structure-borne origin. Whilst there is an increased understanding of the physics involved, the development of manageable methods for its analysis is . limited. Methods of analysis are hindered due to the vast amount of data needed to describe dynamic characteristics and because the methods used to acquire such data (measurement or prediction) are difficult, time-consuming and in many instances cannot be expected to reliably obtain details at all. To overcome the problems the proposed research will consider a statistical formulation of the structure-borne sound transmission problem. In doing so, not only is the amount of data required for an analysis significantly reduced but also the I precision with which the data is procured is relieved. Training content (objective. benefit and expected impact) Beneficiaries of the work will be widespread since an original. Scientific approach to the transmission of structure-borne sound will be developed. The generality of the approach means that it is applicable to many branches of engineering, i.e. buildings, ships, aircraft and road vehicles, where, despite undoubted uses, a prediction of noise due to structure-borne sound is at present intractable. The approach has therefore clear practical application. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Re(search)' (2014-2020).

assistant: **Innovation**

Re(search) will connect the citizens of Dublin with research through two fringe-festival events held in 2016 and in 2017. For each event, Dubliners will be invited to the iconic Front Square of Trinity College Dublin where they will explore how research is addressing societal challenges (the same societal challenges laid out in H2020). The societal challenges will be explored using a range of formats including comedy, drama, dining, story-telling, and citizen-science. These have been chosen to spark conversations between researchers and citizens on issues that matter to people’s lives. Conversations will allow citizens to construct their own views on research topics and the role of research in our society (and as a career). Constructivist approaches to learning are known to lead to enhanced learning outcomes in formal learning settings. This proposal is based on the idea that a constructivist approach to learning can also be applied to informal learning environments, such as Re(search) Night.Dubliners will be made aware of the two Re(search) events through an advertising campaign on Dublin’s Metro train (based on an award winning model designed by the coordinator). Evaluation of the project will be integral to its success with best-practices applied at all stages. Re(search) 2016 and 2017 will be delivered by a management team that has considerable experience in science communication, science education, public engagement and project management. The Re(search) concept outlined in this proposal is a novel way to engage large numbers of citizens. It is based on a number of previous, successful, campaigns and has a strong grounding in published best-practice.


**Keywords:** Societal Challenges, Citizen-science, constructivist approach to communication, multi-disciplinary,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ASSESSMENT AND ENGINEERING OF EQUITABLE, UNBIASED, IMPARTIAL AND TRUSTWORTHY AI SYSTEMS' (AEQUITAS) under Horizon Europe.

assistant: **Objectives**

AI-based decision support systems are increasingly deployed in industry, in the public and private sectors, and in policy-making. As our society is facing a dramatic increase in inequalities and intersectional discrimination, we need to prevent AI systems to amplify this phenomenon but rather mitigate it. To trust these systems, domain experts and stakeholders need to trust the decisions.Fairness stands as one of the main principles of Trustworthy AI promoted at EU level. How these principles, in particular fairness, translate into technical, functional social, and lawful requirements in the AI system design is still an open question. Similarly we don’t know how to test if a system is compliant with these principles and repair it in case it is not.AEQUITAS proposes the design of a controlled experimentation environment for developers and users to create controlled experiments for- assessing the bias in AI systems, e.g., identifying potential causes of bias in data, algorithms, and interpretation of results,- providing, when possible, effective methods and engineering guidelines to repair, remove, and mitigate bias,- provide fairness-by-design guidelines, methodologies, and software engineering techniques to design new bias-free systemsThe experimentation environment generates synthetic data sets with different features influencing fairness for a test in laboratories. Real use cases in health care, human resources and social disadvantaged group challenges further test the experimentation platform showcasing the effectiveness of the solution proposed. The experimentation playground will be integrated on the AI-on-demand platform to boost its uptake, but a stand-alone release will enable on-premise privacy-preserving test of AI-systems fairness.AEQUITAS relies on a strong
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Transnational access and enhancement of integrated Biological Structure determination at synchrotron X-ray radiation facilities' (BIOSTRUCT-X).

assistant: **Innovation**

The BioStruct-X consortium has 19 partners from 11 EU member and associated states, who lead in facility provision and research in structural biology using high brilliance X-rays, provided by state-of-the art synchrotrons and a free electron laser. BioStruct-X will provide integrated transnational access via 42 installations in four key areas: macromolecular X-ray crystallography, small angle X-ray scattering, X-ray imaging, protein production and high-throughput crystallisation. All installations provide on-line data analysis tools and remote experiment control. Transnational access will be critically enhanced by four targeted joint research activities: a) new data processing tools, to the benefit of access to applications in macromolecular X-ray crystallography; b) an integrated on-line sample characterisation system, to the benefit of the access to small angle X-ray scattering, c) correlated fluorescence light microscopy components that will enhance X-ray imaging applications offered for access; d) a toolbox for mammalian cell line expression, to the direct benefit of the access to protein production facilities. The BioStruct-X project will offer a central Batch Allocation Group proposal mechanism to promote project excellence by combining different methods and encouraging multi-site applications. The networking activity integrates all activities and combines them with those of other I3 actions under the ESFRI project INSTRUCT for future coordinated infrastructure activities in structural biology. The efficient management structure has four transparent layers: the coordinator, a six-member executive board, three work package coordinators and the general assembly comprising three user representatives and all partners. Thus, BioStruct-X will establish a state-of-the-ar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Broadband Urban Rural Based Open Networks' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Building on the work already accomplished in RACE, the BOURBON project seeks to address the issue of providing cost-effective, scaleable access to ATM-based advanced services for SMEs in the wider context of Europe and the Information Society. There are two parallel streams running through the project, one Technology focused, the other User focused. It is within the convergence of these two streams that the project will demonstrate scaleable solutions that will allow SME-based users access to services and applications in advanced communications.The overall goal is to define a network and service architecture that takes account of what is already present in terms of networks, hardware and software today, which will then support the move to higher bandwidth services whilst always maintaining a realistic view on what is required by SMEs and ultimately what they can afford.Expected ImpactSMEs represent a significant sector of the economy, providing employment, contributing to national production and, very often, representing an important source of innovation. BOURBON plans to integrate, in a scaleable way, networks and telecommunications services such that an SME may connect with a certain terminal at a certain bandwidth for a certain cost, and with that utilise a needed subset of services in an integrated manner. The contention is that well-managed and efficient use of such technologies and services will allow SMEs, disadvantaged by resources or (in the case of rural areas) location, to compete on a more equal basis with larger or more centrally located companies in the context of the Single European Market.In 1997 and beyond, the following activities of BOURBON are of prime importance:Continued active participation in the Chains and domains and dissemination activities,Co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Functional characterisation of mitochondrial metabolic adaptations to innate sensing in dendritic cell subsets' (MITOMAD).

assistant: **Concept**

Immunometabolism is an emerging research field that promises to generate novel targets for manipulation of functional responses in immune cells. Pioneering studies are beginning to unveil how innate sensing leads to metabolic reprogramming of immune cells. We became interested in the possible metabolic consequences of innate sensing by myeloid cells because of our previous work showing how mouse and human dendritic cell (DC) subsets detect danger signals from microbes and damaged tissues. Our current data show that sensing of live bacteria triggers a profound reorganisation of the mitochondrial electron transport chain (ETC) in macrophages, with a switch in the relative contribution of ETC complexes I and II to mitochondrial respiration that impacts immune response. As we pursue novel strategies to manipulate DC function, and supported by our preliminary data in DCs, we hypothesise that innate sensing induces mitochondrial adaptations in DCs and that targeting mitochondrial metabolism will affect DC function. Our goals are: 1) to characterise how innate sensing of danger signals from microbes or from tissue damage modulate mitochondrial adaptations and metabolic reprogramming in mouse and human DC subsets; 2) to dissect the molecular mechanisms that connect innate sensing and mitochondrial adaptations in DCs, using biased and unbiased cutting-edge proteomics approaches; 3) to address the impact of manipulating mitochondrial biology on mouse and human DC metabolism and function; and 4) to assess the functional in vivo effects of targeting mitochondrial biology in DCs in homeostasis and disease. The characterisation of the molecular mechanisms that link innate sensing and mitochondrial metabolism with DC function will open new avenues for basic research in mitochondrial b