RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Terragenesis: Using landscape ontogeny to predict the persistence of species' (TERRAGEN), addressing dissemination and exploitation.

assistant: **Impact**

Biodiversity scenarios have the potential to exert a strong influence on public perception of the current biodiversity crisis, and on national and international policies to mitigate that crisis. Here, I propose to generate a novel conceptual and analytical model of biodiversity loss, and combine that with deforestation models to generate biodiversity scenarios for the world’s most species rich ecosystem, the rainforests of the humid tropics. Studies of the ecological consequences of habitat fragmentation almost entirely ignore the historical patterns of landscape change that have led to habitat patches being distributed in the way they are.  I have developed a simple random sampling model that shows how explicit consideration of landscape ontogeny generates a remarkably diverse set of testable predictions about biodiversity patterns in fragmented landscapes.  The model, termed terragenesis, combines the random sampling hypothesis with a landscape terrageny, the latter representing the historical relationships between patches much as a phylogeny represents evolutionary relationships among species.  I propose to extend the simple model based on the random sampling hypothesis to incorporate real-world complexity such as variation in rates and timing of historical habitat loss, spatial variation in habitat quality within patches, species dispersal among patches and the way in which matrix habitat influences those dispersal patterns, and variation among species in their susceptibility to habitat loss and fragmentation. I will combine the analytical biodiversity predictions with modelled scenarios of deforestation and logging damage across the humid tropics that my research group is already developing to generate biodiversity scenarios for the world’s most biodiverse biome.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Using blood vessel organoids to investigate acquisition of hemogenic potential during human development.' in the context of a Horizon Europe call.

assistant: **Objectives**

Hematopoietic stem cells (HSCs), responsible for generating all blood cells, are produced during embryonic development in the aorta of the aorta-gonad-mesonephros (AGM) region. This process involves specialized endothelial cells (ECs), called hemogenic endothelial cells (HECs), undergoing an endothelial-to-hematopoietic transition (EHT), which leads to the formation of HSC precursors (pre-HSCs) that mature into functional HSCs. However, the regulation of HEC specification and EHT remains poorly understood. The suportive microenvironment in the AGM includes various factors like growth factors, cell interactions, and biomechanical forces, such as  shear stress induced by blood flow, all of which are crucial for HSC generation. In vitro production of HSCs from pluripotent stem cells has been challenging, posing a barrier to addressing the shortage of HSCs for clinical treatment of blood-related diseases. Blood vessel organoids (BVOs), derived from induced pluripotent stem cells (iPSCs), offer a promising model for studying HEC specification and EHT, as they consist of a network of arterial ECs. The first objective of this proposal is to develop a modified protocol for BVO culture to induce the formation of HECs, EHT, and the generation of (pre-)HSCs from human iPSCs. Immunostaining, flow cytometry, single-cell RNA-sequencing, and functional hematopoietic assays will be used to evaluate the potential of human (h)BVOs. Data on hBVOs will be compared with published data from human AGM populations. The second objective is to study the impact of shear stress on EHT by using a new RUNX1-GFP reporter iPSC line and time-lapse confocal microscopy. These hBVOs will be cultured in a microfluidic system to simulate pulsatile blood flow, mimicking in vivo conditions in the AGM. This ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Inter-european terahertz action' under Fourth Framework.

assistant: **Concept**

The group enjoys SME participation and strong industrial support across The Network aims to develop new technologies in the area of terahertz frequency (100 Ghz - 10 Thz) electronics. For this purpose the programme the EC. The Network Programme will provide excellent training draws together Electronic Engineers, Materials Scientists, Semiconductor opportunities across a range of areas, since the work proposed is inter-disciplinary in nature. Fellows will gain experience in: Physicists, Quasi-Optics Specialists and Microwave Engineers from semiconductor and superconductor device design and processing, Industry, Universities and Research Organisations across the EC toe develop new technologies. The group will exploit these advances in electromagnetics, waveguide circuit design, micromachining. quasi-optical commercial areas of communications, surveillance and remote sensing, in measurements, plus the underpinning physics of this work. Secondment addition to the traditional specialised scientific application areas of periods in industry are also proposed. astronomy and spectroscopy. The development of genuinely low-cost, mass-producible systems is an important objective of the Network's mission. We have identified five crucial areas at the interface of Physics and Electronic engineering in the development of Thz technology. * Development of standardised methods for characterising and testing materials components and systems for Thz applications. * Tune able cw and pulsed solid state Thz sources, of which the most advanced are the quasioptical hot hole lasers * Passive devices: Modelling and development of micromachining for low-cost fabrication. * Active solid state components to provide sources, detectors, mixers and amplifiers that are integratable into practical circuit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Capacity-building and transnational cooperation for National Contact Points (NCPs) for the EIC under Horizon Europe' (NCPs).

assistant: **Concept**

ACCESS2EIC is a 7 year coordination and support action which builds upon the foundations laid by previous EIC support networks and in line with the new Horizon Europe Framework Programme. Access2EIC aims to empower National Contact Points that have been nominated under the new Horizon Europe - European Innovation Council and European Innovation Ecosystems, and facilitate cooperation amongst NCPs to provide enhanced service across Europe. Specifically, the proposed network aims to:(1)Improve professionalisation and skills of NCPs across Europe which in turn will help to simplify access to Horizon Europe calls, lowering the entry barriers for newcomers, and raise the average quality of proposals submitted particularly for women entrepreneurs and in widening countries;(2)Identify and share good practices, promote trans-national cooperation and raise the general standard of support to programme applicants, taking into consideration the novelties under Horizon Europe, the third pillar and the various stakeholders within the EIC-EIE;


**Keywords:** European Innovation Council; Pathfinder; Accelerator; Transition; SME; Capacity building; National Contact Point; European Innovation Ecosystem; Synergies; Key Success Factors; Horizon Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Screening for liver fibrosis - population-based study across European countries', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Liver cirrhosis is a very common and severe chronic disease, responsible for high morbidity, impaired quality of life, major healthcare costs, and poor survival, causing an estimated 170,000 deaths per year in Europe. Liver cirrhosis is preceded by a long period of slowly developing, asymptomatic, liver fibrosis; most commonly caused by non-alcoholic fatty liver disease (NAFLD, related to obesity and type 2 diabetes), alcohol, and hepatitis B or C virus infection. There is no treatment available to reverse advanced liver cirrhosis.  However, if fibrosis could be detected early, all of the major causes are still amenable to prevention and treatment. Early diagnosis of liver fibrosis in the general population is therefore crucial for the estimated 10 million Europeans with undetected liver fibrosis.The LiverScreen project aims to develop a targeted screening methodology to identify persons with asymptomatic liver fibrosis and cirrhosis among the general population. This methodology involves: 1) identification of groups from the general population at high risk of having chronic liver disease, 2) screening their liver stiffness with the innovative transient elastography (TE) technology (until now only validated in patients with known liver disease) for diagnosis, and 3) determining the right follow-up screening regime. Within the LiverScreen project 8 European countries will collaborate and perform research in over 34,000 subjects to develop the screening methodology and demonstrate its accuracy, clinical value, cost-effectiveness, acceptability, and potential to be implemented by healthcare systems throughout Europe.Using the LiverScreen program, diagnosis at an early stage can stop liver disease progression and have a subsequent long-term impact on liver disease morbidity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The bionic ear, a new approch to trigger repair mechanisms in the inner ear' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

This project aims at designing a new therapeutic approach for the restoration of sensory function after damage in the inner ear auditory and balance organs. This goal will be reached through the better understanding of the regenerative and neo-synaptogenesis" potential of inner ear sensory neurons and on how this potential can be enhanced in vivo in hearing impaired animals. Stem cell lines from normal animals and form transgenic animals over expressing neurotrophic factors will be established and these cells will be further manipulated using genetic engineering. The ability of these cells to support regeneration in the inner ear will be assessed with functional in vitro and in vivo approaches. This cell therapy approach will be combined with existing biopolymer implants and with existing cochlear electrode prosthesis into a BIOELECTRODE implant."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Emergency evaluation of convalescent blood and plasma for Ebola Viral Disease (EVD) in affected West African countries.' (EVD).

assistant: **Concept**

The objective of this proposal is to urgently determine the efficacy, safety and feasibility of convalescent whole blood (CWB) and convalescent plasma (CP) therapy, as a treatment for patients with Ebola Viral Disease (EVD) to reduce the case fatality rate in the present EVD epidemic in West Africa. The trial will take place in three consecutive phases; i) initial phase to initiate harmonized standard supportive care (SC), ii) evaluation of CWB iii) evaluation of CP. Supportive care (SC) including intravenous hydration and shock management will be standardised and made available to all patients. Day 14 mortality will be used to determine primary outcome. Survival for patients treated with CWB + SC or CP + SC will be compared to SC alone using a non-randomised open-label design. Based on available figures, a 20% decrease in the case fatality rate will be considered proof of clinical efficacy. Internationally agreed stands of ethics and human rights will be applied for the duration of the trial. Written consent will be requested from patients and/or guardians of patients. Every consideration will be given to the safely of health-care workers involved in the trial, including their consent to be involved and adequate training and psycho-emotional support. Given the study context, community communication will be prioritized. We propose a unique partnership of academics, clinical trial units, non-governmental organizations, international research networks, international and local actors to conduct a clinical trial according to the highest standards attainable in the current context. If found to be effective, this intervention can be scaled-up relatively rapidly as the trial will provide the information required to mobilize local partners, with major public health implications
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'An innovative process to extend commercial bioprosthetic heart valves lifespan.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Heart valve disease is one of the main causes of morbidity and mortality worldwide. In 2017 around 400.000 patients underwent heart valve replacement. Mechanical (MHVs) and Bioprosthetic (BHVs) Heart Valves are the most used substitutes. However, the former  have  problems related to their thrombogenicity, the latter durability issues that limit their use.Recently an alarming correlation between the presence of the alpha-Gal epitope and a premature BHVs degeneracy was reported.BioCompatibility Innovation (BCI), an Italian biotechnology Startup, aims to bring on the market FACTA: an innovative treatment for inactivating the alpha-Gal xenoantigens in biological tissues that can be used to manufacture BHVs substitutes. FACTA has been patented and its reliability and efficacy have been validated by extensive in-vitro investigations that confirm a significant decrease in calcification propensity (over 85%) and a better resistance of the treated tissue, compared to the current chemical treatments of BHVs manufacturers. Currently a pilot study is ongoing, involving the implant of commercial BHVs treated with the FACTA protocol in swine with a one-month short permanence time (assessment of the acute toxicity and immunological tolerability of the FACTA treatment). BCI will evaluate a more in-depth validation of maintaining the physiological/structural efficiency of FACTA treated BHVs in an animal model implant for the expected 6-month duration.The global BHVs market is constantly growing: 11.71% CAGR between 2013 and 2022. FACTA can be perfectly integrated into the production flow of BHV manufacturers, without requiring any change in the supply chain. BCI raised about 850.000 € by founders and grants. FACTA received the ""Seal of Excellence"" by European Commission in June 2018.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Production of renewable methanol from captured emissions and renewable energy sources, for its utilisation for clean fuel production and green consumer goods' under Horizon 2020.

assistant: **Concept**

Methanol, needed in industry as a chemical building block (plastics, solvents, additives) and as transportation fuel, has been traditionally produced from coal or natural gas, dependent on fossil fuels (limited supply), contaminating land (mining, drilling) and emitting CO2 to the atmosphere (global warming effect). Nowadays, crop-based biofuels are also used with the same purposes, but consume huge water and land resources for their production.Carbon Recycling International (CRI), founded in 2006 in Iceland, produces renewable methanol (currently 4 kt/year in the George Olah plant) from industrial CO2 emissions and Renewable Energy Sources (RES), through a novel process of clean fuel production (Vulcanol®). This proprietary technology is called Emissions–to-Liquids (ETL) and is certified ISCC Plus by the International Sustainability and Carbon Certification system. While conventional production of methanol emits up to 4 t CO2/t methanol, our ETL plant fights global warming by consuming 1.4 t CO2/t of Vulcanol® produced and requires approximately 1500 times less land and up to 15,000 less water than crop based biofuel, eradicating ethical concerns about competition between biofuels and human food production. Vulcanol® is an efficient energy carrier that can be used to easily store and transport off-peak renewable energy, stabilizing the power grid and supporting expansion of RES. ETL helps to fulfil stricter EU regulations regarding the use of advanced renewable fuels and RES; improves air quality in industrial areas, thus, health of their population and employees and supports employment creation (25 skilled jobs per ETL plant). During this phase 2, CRI aims to a) scale up the technology and adapt ETL plants to economically operate with RES, b) to attract investment to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Drug repurposing and discovery multidisciplinary training network', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Drug repurposing (or repositioning) is the application of previously identified drugs or compounds to treat new indications.The International Rare Diseases Research Consortium (IRDiRC) set as main goal for 2027 that 1000 new therapies for rarediseases will be approved. One of the levers to achieve this goal includes the repurposing of already existing and marketeddrugs. In this context, DRUGtrain offers a timely paradigm for multidisciplinary research ideal for improving drug repurposingand development strategies of compounds, with Autosomal Dominant Polycystic Kidney Disease (ADPKD) as example.Identifying compounds for repurposing requires a broad variety of approaches. Therefore, the aim of DRUGtrain is to offer amultidisciplinary research training program to young researchers preparing them to become leading scientists able tointegrate molecular and pharmacological data, and translate fundamental research questions to the (pre)clinic and viceversa.The research objectives of DRUGtrain are: 1) To identify potential drug targets and drug candidates for repurposing usinginnovative bio-informatics and cheminformatics approaches; 2) To perform drug testing/drug screenings in advanced in vitroand in vivo models, ultimately leading to testing of new treatment strategies; 3) To clarify drug mechanisms, and identify andreduce adverse events using state-of-the-art technologies from in silico and wet lab methodologies. Complementary trainingthrough courses will cover additional topics in drug repurposing and drug discovery as well as scientific skills, personaldevelopment, commerce and entrepreneurship.In DRUGtrain, 6 academic and 4 private sector beneficiaries/partner organisations and 1 NGO are collaborating in joiningforces to intensify network activities between academia, in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Elucidating the Mechanism of Lubrication for Sliding Droplets: Hydrodynamics, Surface Forces, and the Role of Surfactants and Polymers' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Emulsions are the base for variety of products in industry, food production, cosmetics, pharmacy, and new materials. Many of the important applications of emulsions are controlled by interactions between oil droplets and solid surfaces. The aim of this project is to carry out novel investigations into the interaction between droplets and solid surfaces undergoing sliding contact. Importantly, and for the first time, this project will combine force measurements and spectroscopic characterisation of the system, enabling us to ‘see’ and ‘feel’ the interaction between droplet and solid surface under sliding conditions. In addition, the project will take advantage of the most advanced form of atomic force microscopy for studying the contact between two surface: interferometric-AFM. A further aim for the project is to go one step beyond considering the droplets as representative of the dispersed oil phase in an emulsion. The interaction of a surfactant-coated oil droplet with a solid surface will be a useful model system for considering cell-surface interactions. The control of attachment of cells to surfaces within microfluidic channels is a key goal for studies of cell immune response for disease detection.