RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Synthetic kinesin analogues: A transition metal complex that can walk' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The goal of the research project proposed is to design, synthesise, operate and fully characterize a wholly synthetic molecular machine mimicking the mechanical action of the kinesin motor protein, namely unidirectional, hand-over-hand (also known as “passing leg”), mechanically processive motion to propel a molecule along a pre-defined molecular “track”. To accomplish this purpose, two sets of kinetically stable binding units must be present on the walker unit. These two units must have orthogonal binding requirements and the relative binding affinities of one of the units within the binding points along the track must be switchable by a stimulus that does not affect the other binding unit.To mimic the kinesin action in a synthetic molecular system, metal-binding events of the motor molecule along the functionalized track are exploited to control the thermodynamics and kinetics of biased Brownian motion in a functional molecular system. In concrete, the binding units of the walker contain two metallic centres, a palladium(II) complex and a platinum(II) complex, which can undergo a proton-mediated ligand exchange based on two orthogonal mechanisms, because while the exchange of the palladium(II) complexes is achieved thermally, the one of the platinum(II) centres is photochemical.This system can be considered a part of the state-of-the-art interest  to develop wholly artificial chemical systems which display the propety of sequential processivity. The novelty is that the proposed system is based on a pH-dependant ligand exchange on Pd(II) and Pt(II) complexes, which is expected to result in a highly directional movement under termodynamic control.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Global existence vs Blow-up in some nonlinear PDEs arising in fluid mechanics' (TRANSIC) under Seventh Framework.

assistant: **Objectives**

The present project aims at studying qualitative properties of some nonlinear Partial Differential Equations arising in fluid mechanics. It is divided into 3 parts.Part 1 and Part 2 address the study  of some classes of 1D hydrodynamic models, namely, the inviscd Surface Quasi-Gesotrophic equation (SQG)  and the generalized Constantin-Lax-Majda (gCLM) equation. Both models are closely related to the 3D Euler equation written in terms of the vorticity and are therefore mathematically interesting. More specifically, Part 1 is devoted to the study of particular solutions of the inviscid (SQG) equation which blow up in finite time. Those particular solutions  turn out to satisfy a 1D non local  equation which are a particular case of  (gCLM) equation. Therefore, we focus on that 1D equation and we prove finite time blow-up by using methods coming from harmonic analysis and the so-called ""nonlocal maximal principle"" or  the ""modulus of continuity method"" introduced by Kiselev, Nazarov and Volberg.In contrast to Part 1, Part 2 is devoted to the proof of a global existence theorem for another particular case of (gCLM) equation. Unlike Part 1 where the ""modulus of continuity method""  will be used only in one step of the proof, Part 2 is completly based on the use of the ""modulus of continuity method"".Finally, Part 3 deals with the Muskat problem which describes the interface between two fluids of different density but same viscosity. This part is centered around a global existence result due to Constantin, Cordoba, Gancedo, Strain and is based on the use of a new formulation of the Muskat problem  recently obtained  by Lazar.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Linked Lives: Consequences of Long Commuting for the Health of All Family Members'.

assistant: **Innovation**

Passive commuting–regularly recurring travel between home and work by a motorized vehicle or public transportation–is an integral part of our lives. Commuting may take a toll on the health of commuters and their family members. Current research offers a limited understanding of whether commuting’s health impacts are socially patterned. Information about whether long commuting affects family members is scarce. A comprehensive inquiry into this topic is needed to understand what commuting means for population health.COMFAM’s main objectives are: 1) to investigate the impact of long commutes on commuters’ physical health, 2) to investigate whether long commutes have adverse effects on non-commuting partners’ health and well-being, 3) to assess the effects of parental long commutes on children’s health and social outcomes, 4) to examine whether changes in commuting during and after the COVID-19 pandemic have brought any changes to the health and well-being of the family members, and 5) to examine whether the health effects of long commutes differ across population subgroups, and whether these effects are short- or long-term.COMFAM is ambitious and highly innovative. It will use high-quality Nordic register data, enabling us to examine comprehensive objective indicators of health, investigate the heterogeneous health effects of long commuting, and employ novel methods to address endogeneity and help establish a causal pattern. We will also leverage rich survey data from the UK, US, and Germany to investigate mechanisms that may underlie commuting-health relationships and assess health declines not yet requiring medical treatment.COMFAM is also important. In addition to impacting population health, the negative health effects of commuting may reduce employee performance, indu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Excellence in Public and Professional Decision Making: Boosting Deliberate Practice and Handling Biases through Immersive Cognitive and Emotional Reinforcement Strategies and Tools'.

assistant: **Objectives**

The xDELIA project is designed to investigate a number of contexts where technology enhanced learning is expected to improve the quality of financial decision making.  xDelia pursues two major and closely linked objectives.  The first is to provide a number of discrete learning interventions, which can be delivered either through a web-based trading platform or in a day-trading facility, to enhance the quality of financial decision-making by private investors trading on their own account.  Within that overall objective, the principal goal is to address issues of emotional regulation in financial decision making.  In common with many other areas where technology has been used to assist learning, financial training has largely focused on imparting propositional knowledge and increasing people's intellectual understanding. However, our work to date has shown that despite investors having considerable appropriate knowledge, their actions can still be ruled by their attitudes, habits, or emotional states. Emotions not only mediate rapid expert situation recognition and the application of expert intuition, but they also give rise to important persistent biases in decision-making through framing effects and the disposition effect in particular.  Game based technologies are becoming proven as a method of learning, particularly as they can place people in virtual situations.  In the context of financial decision making, xDelia will use serious games to analyse and train behavioural patterns and to support the non-formal and informal learning process.  The project will produce learning interventions which employ physiological sensors alongside serious games.  Wearable sensor equipment will help build a picture of a person's emotional state.  Data collected via sensors in both gam
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Immune function of NK cells' to be submitted under Seventh Framework.

assistant: **Abstract**

In this project, we propose to explore a new area in biological research aiming at dissecting emerging of properties of the innate immune responses. Our system model is the Natural Killer (NK) cell. Specifically, we will investigate the mechanisms by which these players of innate immunity achieve tolerance to self and participate to immune responses. Multidisciplinary approaches will be combined to achieve groundbreaking results at nanoscopic and macroscopic scales on the following issues:- How NK cells are educated to self-tolerance?- How NK cells distinguish their targets from normal cells?- How NK cells participate to immunological memory?THINK (THe Immune function of Natural Killer cells) is a challenging project supported by an array of preliminary data obtained by our team of investigators in various fields of expertise:- innate immunity and NK cells in human and mouse models- random insertional mutagenesis in the mouse- genome-wide epigenetic, transcriptomic and RNAi analysis and- state-of-the-art optical imaging techniques from intravital biphoton microscopy to the quantification of proteins in nano-sized areas of the cell.THINK is thus a multidisciplinary project that bridges disciplines: immunology, biophysics, genetics and epigenetics. In a scientific perspective, we think that this project will open new technological and scholar horizons, in reassessing the actual concepts on the links between innate immunity, tissue homeostasis and stress response. In a clinical and translational perspective, we also think that this project will help to design innovative NK cell-based therapies and immunomonitoring protocols.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Function of DUX4 in skeletal muscle and non-muscle tissues'.

assistant: **Objectives**

Somatic expression of the retrogene DUX4 in skeletal muscle is associated with the development of the common myopathy facioscapulohumeral muscular dystrophy (FSHD). As FSHD patients mainly present with muscular symptoms, research in the FSHD field has focused on unraveling the functional consequences of DUX4 expression in skeletal muscle. Research on DUX4 expression in non-muscle tissues is limited, but increasing evidence suggests a biological function for DUX4 in somatic tissues. I aim to characterize DUX4 expression in non-muscle tissues, to determine the genome-wide transcriptional consequences of DUX4 expression, to identify DUX4 target genes in these tissues, and to establish whether treatment with DUX4 antisense oligonucleotides negatively impacts somatic tissues in which DUX4 has a biological function. First, I will use a combination of quantitative reverse transcriptase PCR, immunofluorescence staining, and flow cytometry to establish which tissues and what cell types express DUX4 in human and mouse. Next, I will use the innovative technique of single-cell RNA sequencing to determine the autonomous and non-autonomous functional consequences of DUX4 expression in DUX4-positive tissues. In parallel, to establish which genes and pathways are direct targets of DUX4 and whether tissue-specific differences exist, I will employ DUX4-chromatin immunoprecipitation sequencing. Finally, I will determine the effect of DUX4 suppression in vitro and in vivo. The proposed work will provide in depth analysis into the biological function of DUX4 in somatic tissues, contribute to the long-standing enigma in the field why FSHD presents as a muscle-specific disease, and provide guidance to DUX4-targeted therapies that are currently being developed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Reading difficulties and second language learning: The effects of orthographic (non) transparency' to be submitted under Sixth Framework.

assistant: **Abstract**

The aim of the present research is to advance knowledge on the subject of first (L1) and second (L2) language reading in normal and poor readers, considering the unique orthographic features of L1 and L2. The interaction between the following variables is analysed: Readers (poor, normal), Language Orthographic Complexity (transparent, non-transparent), Language Familiarity (L1, L2), Gender (males, females). The research objectives are to examine: 1. the (developmental) trends associated with accuracy and s peed of reading letters, isolated words and text in L1 and L2; 2. the differences between normal and poor readers on accuracy and speed of processing letters, words and text in L1 and L2; 3. whether linguistic features such as orthographic depth and morpho -syntactic complexity may differentially interact with readers¿ individual characteristics in determining the course of L1 and L2 reading development; 4. gender differences in relation to the above. Two studies are designed to address the above objectives. First, a longitudinal study will use American children who have English L1 and Greek L2. A second study with one experiment will examine Greek children with Greek L1 and English L2. Data from both studies will be used to directly investigate the effects o f orthographic complexity on L1 and L2 literacy development in normal and poor readers. Innovative aspects of the project include the implementation of powerful techniques such as Item Response Theory and Growth Curve Analysis in combination with the study of literacy development across languages. The project builds on the applicant¿s existing contribution in cross-linguistic research. It addresses issues related to the literacy skills of children with learning problems and has implications for language lea rning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Characterization of the epigenetic nature of a gametophytic lethal mutation in Arabidopsis rhaliana' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Recent findings point to a relevant role of epigenetic phenomena in developmental issues in animals and plants. Epigenetics has been described to affect cancer, fate programming and developmental transitions. In the vegetal kingdom it has been related to e mbryo development, floral transition, vernalization and transgene silencing. The analysis of two independent insertional mutants in a SWI3-like gene, in the model plant Arabidopsis thaliana, suggests that the Swi/Snf complexes are involved in regulation of transcriptional silencing of genes affecting gamete formation and embryo development. The morphological characterization of such a defect and the link to silencing will reveal a new element in the epigenetic mechanisms, and will establish new tools for ga mete and embryo development studies. It is hypothesized that the disruption of the SWI3-like gene originates the epigenetic modification of a second gene, causing alterations in the gamete formation. Positional mapping of this gene would prove the current hypothesis and would reveal a key element in gamete development. The proposed research activity is also taking into account the mutational analysis of other components of the putative Swi/Snf complex in Arabidopsis. Different T-DNA collections will be sear ched for mutants in such a genes, and the effect of these mutations will be described. Finally, plants expressing Swi3-like and Bsh (Snf5-like) proteins fused to an epitope will allow the tracking of these proteins, and the purification and co-immunoprecip itation of Arabidopsis Swi/Snf complexes. The final aim of this proposal is the combination of exciting research topics as chromatin remodeling and epigenetics with a rising model organism with a recently sequenced genome as Arabidopsis thaliana.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Forum for European - Australian science and technology co-operation, phase II' under Sixth Framework.

assistant: **Concept**

The strategic objectives of the Forum for European - Australian Science and Technology Co-operation are to: - highlight existing S&T co-operation between Europe and Australia; and - improve this co-operation by identifying priorities and enhancing the quality, quantity, and visibility of future action. Specific objectives are: - to increase the links between European and Australian scientists; - to better identify and demonstrate co-operation; - to improve the process of providing information on program mes promoting co-operation between Australia Europe; - to exchange best practices; - to provide opportunities for presenting state of the art S&T, and improve the prospects for co-operation in these fields. A series of work packages will ensure effecti ve delivery of these objectives. They will create: 1. A website portal to European - Australian S&T collaboration, the FEAST network, databases, and activities; 2. An online database of researchers and research projects involved in collaborative EU - A ustralian research; 3. Helpdesk services to Australian and EU researchers seeking enhanced research collaboration opportunities; 4. Networks of researchers involved in and interested in collaboration, and forums to share information and experiences; 5. Doc umentation and promotion of existing collaboration, and opportunities for new collaboration; 6. Bilateral research networks to promote collaboration; 7. An Industry - Science network; 8. Thematic networks and expert groups in areas of mutual priority; 9. O rganisation of a bienniel high profile Policy Dialogue Conference; A further work package will manage and coordinate the tasks. FEAST will be managed by a small secretariat assisted by an Executive Board and a Joint Advisory Group representing key stakehol ders. The FEAS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sustainable Hybrid Dual Burner' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

bioburner is the answer to the market to use biomass on industries with uninterrupted heating needs and strict production times.We have developed a hybrid dual burner that combines the best of two technologies on a single burner, avoiding the problems associated with them, with a payback < 1 year.On the one hand biomass:- pros:,low cost of operation and neutral CO2 emissions;- cons: high inertia, which means stop/start times very high;On the other, fossil:- pros: instantaneous response time and already present in most installations;- cons: high OPEX and CO2 emissions;bioburner is compact, safe, plug and play, scalable, cost-effective, efficient, reducing thermal energy cost by 50%, reliable, being able to operate automatically with two fuels and sustainable, reducing CO2 emissions by 95%.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Flexible Speech Recognition System' under Seventh Framework.

assistant: **Concept**

The present idea is to convert a research tool of the ERC-funded project (269670) into a working single-word Automatic Speech Recognition (ASR) demonstration system to attract speech technology companies to use this method in commercial ASR systems. The difference to existing ASR systems is that no training is needed; a wide range of speakers and dialects are covered; it can handle non-standard, non-ideal speech; it is less susceptible to interference from noise; and the system can be easily adapted to new languages. Our planned ASR system [the Flexible Speech Recognition system (FlexSR)] has evolved from a linguistic model of phonological representation, which is the focus of the present ERC grant.