RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'HPCN tools for enhanced hydrodynamic design of fast ships on parallel computing platforms' (FLASH).

assistant: **Innovation**

The overall goals of the project are: to provide the fast ship construction community with a new HPCN system for efficient exploitation in the hydrodynamic design and optimisation of hull shapes and structures using heterogeneous parallel computing platforms composed of clusters of workstations and PC's. to demonstrate and assess the developed HPCN system in selected large-scale multi-physics computations typical in ship hull design involving coupling between hydrodynamics and structural mechanics problems. to promote the HPCN system and disseminate the results of the demonstration actions among naval architecture industries by means of product marketing and organisation of workshops. to raise interest for HPCN technology in the European ship construction industry by providing a user friendly parallel application software for both design and optimisation of fast and conventional ferries for passenger and cargo transportation which meets industrial needs.More specifically, the project will focus on development and integration in a parallel computing environment of existing finite elements based simulation software for CFD (Computational Fluid Dynamics) and CSM (Computational Structural Mechanics) to be used as efficient tools for solving relevant problems of the naval architecture industry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Genetics of long-distance migration' to be submitted under Horizon Europe.

assistant: **Abstract**

It is firmly established that the migratory behaviour of animals is largely genetically hard-wired. However, we do not know the genes involved, where these are expressed and how the genetic code guides individuals to fly in a specific direction for more than a month, across deserts, mountain ranges or oceans, to finally reach a wintering area on the other side of the globe. To approach these gaps of knowledge, I propose a coherent research program that builds on my long-term research of migratory genetics. I will use different species of migratory songbirds to investigate three key questions in migratory genetics: (1) how does the inherited migratory program instruct the juvenile on its first journey?, (2) which are the genes that control migratory behaviour and when and where are they expressed? and (3) how have migratory genes evolved across species with different migratory behaviours? The three parts of this program are designed to maximize gain of new knowledge by combining large scale field studies with cutting-edge molecular techniques. I will carry out a translocation experiment and combine it with state-of-the-art tracking methodology to determine how direction of navigation is inherited. By profiling the expression patterns of genes in the brain before and during the first phase of migration using both spatial and single-cell transcriptomics, I will uncover the mainly unknown migration genes and regulatory networks as well as where in the brain these are expressed. Through comparative genomics on the species-rich genus Phylloscopus (in which migration has been lost, gained and increased in distance multiple times during its diversification), I will explore how migration genes have evolved in concert with the migratory behaviours. In summary, this project has th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'From the laboratory to the production Line' (LAB2LINE).

assistant: **Innovation**

The project aims at taking solar cell processes and materials successfully developed within previous RTD projects to manufacturing level. In particular the project will address low cost options for the well known laser grooved solar cell which include screen printing and laser local rear contacts, and will also address manufacturing issues related to the use of n-type multi-crystalline silicon, which has demonstrated excellent quality at lab level.The two project lines are kept separate for faster achievement of scale up, which is an overall goal of the project, but in principle optimised cell processing can be applied to any kind of substrate, and thus to n-type, for instance. The project will verify such option as well. The objectives of the project are to fully test and specify process sequences which can be scaled to volumes compatible with the present growth rate of the PV market already at the end of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Modulation of the release of neurotransmitters from rat and guinea-pig cerebrocortical synaptosomes by metabotropic glutamate receptor agonists' to be submitted under Fourth Framework.

assistant: **Abstract**

There are three pharmacologically characterised groups of metabotropic glutamate receptor (mGluR). Two of these are reported to inhibit and one to enhance glutamate release presynaptically. The host group has a well established project on presynaptic neurotransmitter release evoked by ionotropic glutamate receptor (iGluR) agonists. The project aims to characterise mGluR modulated neurotransmitter release in the cerebral cortex, in vitro and in vivo. An emphasis will be the modulation of iGluR mediated release. The work programme will staxt by using the synaptosomal model and then proceed to test the effects found using microdialysis. Pilot studies have shown that both parts are possible. There are few studies which have detailed the pharmacology of mGluR modulateded release and none which address mGluR modulation of iGluR-mediated release. The study will be aided by the provision of some novel materials from industry. If sucessfull this project will provide the basis for further transnational European collaborations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hybrid Imaging of PET and PrOmpt gamma for preCision RAnge- and biological- guidance in proton ThErapy' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Proton therapy is rapidly being established in the EU as a promising external beam tumour therapy modality offering an increased tumour-dose conformity with better sparing of critical organs and healthy tissue compared to conventional photon therapy. However, full exploitation of its clinical potential is still hampered by non-negligible uncertainties during the treatment planning and delivery, posing the urgent demand of novel real-time techniques for in vivo verification of the proton beam range. To this aim, the objective of this project proposal HIPPOCRATE (Hybrid Imaging of PET and PrOmpt gamma for preCision RAnge- and biological- guidance in proton ThErapy) is to explore the optimal design and clinical potential of an innovative hybrid medical imaging approach that goes well beyond the state of the art, by combining real-time range verification from energetic prompt gammas with Positron-Emission-Tomography (PET) imaging of irradiation-induced or externally injected tracers, to  promote biological- and dose- guidance for personalized, high-precision proton therapy. By improving the quality of the rapidly emerging proton therapy modality, this project will promote longer and healthier lives for cancer patients, with a high societal impact on the EU. Moreover, HIPPOCRATE can potentially go beyond the boundaries of medical imaging in proton therapy, by enabling high quality imaging of a whole new range of promising unconventional radionuclides for diagnostic nuclear medicine imaging, as well as opening the perspective of biological image guidance at the radiotherapy treatment site, independent of the primary radiation quality.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular linguistic networks for natural language processing' (1998-2002).

assistant: **Innovation**

The research project that is presented here has its central theme in the development of molecular linguistics: an approach to the study of natural language which takes as a model molecular biology, in particular the behavior of DNA molecules when recombination takes place. Within this framework we present three main objectives:1. Establishment of syntactic and semantic foundations of molecular linguistics. Formalization of language structure and elaboration of rules.2. Description and construction of what we call molecular linguistic networks: a complex semantic syntactic mechanism which intends to help the analysis and generation of linguistic productions from a molecular point of view.3. Implementation of the theoretical results obtained with a double objective:a. To make a viable application for computing, computational linguistics and artificial intelligence.b. To try a falsation/verification of the hypothesis shown.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Magnetic swArms for liver chemoeMBOlization' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Magnetically actuated untethered microrobots have been proposed in the state of the art since more than a decade towards the dream of accessing remote hard to reach areas of the human body. Nevertheless, some challenges still have to be faced before any microrobot-based therapeutic paradigm can reach the clinical practice. MAMBO (Magnetic swArms for liver chemoeMBOlization) aims at facing some of these challenges by targeting a specific clinical application, namely liver chemoembolization.The proposal stems from the idea to improve cancer chemotherapy and existing chemoembolization procedures by using magnetic forces to collect chemotherapeutics in the target region (through swarm control methods) and to controllably and stably embolize tumor blood vessels. Drug loaded soft magnetic microrobots featured by responsiveness to ultrasound will be developed to this aim. The responsivity to US will enable microrobot swelling and controlled vessel occlusion and at the same time their ultrasound-based imaging to guarantee their tracking in vivo. Magnetic swarm control techniques will be employed to enable microrobots locomotion in biologically-relevant fluids. MAMBO will last 36 months and is articulated in a 24 months outgoing phase carried out at the Chinese University of Hong Kong (CUHK – partner organization) and in a 12 months return phase in Scuola Superiore Sant’Anna (SSSA – beneficiary organization). In the framework of the project I will try to deepen my skills in magnetic swarm control by benefiting from the major expertise of Prof. Li Zhang’s group. At the same time, I will share with them my background in medical robotics and drug delivery systems towards the development and testing of a novel therapeutic paradigm for cancer treatment. During the return phase at SSS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'NMR in Molecular Biology' (1998-2002).

assistant: **Innovation**

The description of the molecular basis of the activity of biological molecules is deeply linked to the knowledge of their three dimensional structure at the atomic level. This is why a lot of effort has been dedicated to the development of techniques, which allow the determination of the structure of biomacromolecules. In the last few decades, NMR spectroscopy has emerged as one of the most powerful tool for the study of the structure and the dynamics of biological macromolecules. It determines about 25% of all new three-dimensional structures and is the only technique capable of providing high resolution structural information on these molecules in aqueous solution.The two proposed meetings of this series NMR in Molecular Biology" will be focussed on Structural Genomics and NMR. Structural Genomics aimed at using high-throughput structure determination and computational analysis to provide three-dimensional models of every tractable proteins. Several pilot projects in Structural genomics are developing over the world and of course in Europe and it is important to emphasise now the specific role of NMR and its complementarity with X-ray studies to increase efficiency and rapidity in structure determination but also to establish stronger links with function. The expected technical improvement from Structural Genomics will and is already transforming Structural Biology, as solving protein structures will become easier. Thus Structural Biology will have to turn to more demanding projects, for example solving the structure of bigger objects or membrane proteins and to be more deeply involved into Biology.IIn the first meeting it is proposed to present the main projects in Structural Genomics under development, the number of structures solved as well as a survey on how expre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'New frontiers in chronic pain management: A personalised support package targeting the mechanistic links between social disadvantage and pain sensitisation'.

assistant: **Innovation**

This project will advance chronic pain treatment by developing a personalised support package tailored to patients' uniqu. e social, biological, and psychological drivers of pain. Chronic pain affects billions and costs Europe €440 billion annually. Socially disadvantaged individuals, especially those of low socioeconomic status, are disproportionately affected, but current treatments primarily target biological and psychological factors, overlooking social elements. This gap may explain the modest and short-lived effects of current treatments, particularly in vulnerable groups. I hypothesise that adding personalised community support—an approach not yet explored for pain—will enhance outcomes and propose four work packages: WP1 Identify causal pathways through which biological, psychological, and social factors mediate the effects of social disadvantage on pain to identify support targets, using latent class mediation analysis of longitudinal cohort data. WP2 Build a personalised support package tailored to individuals' needs and targets identified in WP1, using a scoping review, qualitative study, and feasibility trial. WP3 Evaluate the support package's effects on pain, disability and quality of life through a randomised clinical trial. WP4 Investigate whether selected biological (inflammation, nervous system sensitisation, physical activity), psychological (mental health, self-efficacy), and social (support, isolation) mechanisms mediate the support package’s effect on clinical outcomes using a causal mediation analysis. Multiomics blood profiling, computerised cuff pressure algometry, activity accelerometers, and questionnaires will be employed. This project will advance understanding of how bio-psycho-social mechanisms link social disadvantage to pain and transfor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Active GUrney on Main Rotor blades' (GUM).

assistant: **Innovation**

The project pertains to the wind tunnel testing of an innovative helicopter rotor with Active Gurney Flaps on the blades. The experiments will be carried out in a facility highly specialised for helicopter model testing. The effects of the flap on rotor performances will be assessed in different operating conditions of the rotor, including both hover and forward flight conditions. A particular feature of the experimental set up will be the Particle Image Velocimetry (PIV) system. PIV will be used to carry out some flow field surveys over the blades in order to achieve a better physical insight into the flow behaviour. Moreover, an innovative technique, further developing some recent approaches purposedin the literature, will be used to reconstruct the pressure distribution over the blade section on the base of proper PIV surveys.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Anti-reflection coatings from solution-processable, high-refractive index inorganic/organic hybrid materials' in the context of a Horizon 2020 call.

assistant: **Objectives**

COAT activities aim at developing a new generation of anti-reflection (AR) coatings based on the inorganic/organic hybrid materials advanced in OASIS (Project No: 279587). COAT provides the necessary manpower for screening new formulations and produce large-area demonstrators and illustrative prototypes to persuade major partner of the validity of the proposed technology approach for future commercialisation. To ensure these demonstrators fulfil the needs of coating manufacturers and end-users, a User Committee will be established to obtain insight and specifications on identified AR coatings and enabled applications. We will seek links with, e.g. optical component manufactures, eyeglass producers and developers of large-area photonics, such as lighting and photovoltaics. We will also work closely with curators from the London’s Natural History Museum and the Science Museum –both in close proximity to Imperial College– to include their needs with respect of art display applications. COAT personnel will thoroughly bench-mark our technology, provide a performance evaluation of the coatings and establish sustainability indicators for end-users. To clarify and protect our IPR technology, a detailed market analysis and valorisation potential of enabled applications will be undertaken. Prospects are highly promising. In 2013, the worldwide market for AR coatings was worth close to $3 billion and reached volume demands of 340 ktons; furthermore, market forecasts predict that, between 2014 and 2020, the global market of AR coatings grows at a compound annual growth rate of 8.2 %. This corresponds to a net worth of close to $5 billion by 2020. Our technology, based on readily available solution-processable materials, offers a versatile form factor for a range of application pla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'REPURPOSING FUSIDIC ACID AS A SHORT-COURSE ONCHOCERCA VOLVULUS MACROFILARICIDE: A RANDOMIZED CONTROLLED OPEN-LABEL PARALLEL GROUP INTERVENTION PHASE IIA/B PILOT TRIAL' to be submitted under Horizon Europe.

assistant: **Abstract**

Onchocerciasis (river blindness) is a vector-borne, filarial nematode neglected tropical disease (NTD), affecting an estimated 21 million individuals, 99% of which reside within 31 Sub-Saharan African countries. Approximately 14.6 million onchocerciasis infected individuals suffer skin disease and 1.15 million are visually impaired.Onchocerciasis is prioritized for elimination as a public health problem by The World Health Organisation with ambitious targets set as part of the NTDs Roadmap to 2030. To enable elimination targets from 2030 onwards, WHO and major stakeholders, including funders and product development partners, recognize that a new short-course curative (macrofilaricide) treatment is required (or a short-course agent which permanently blocks parasite reproduction and transmission), as well as a safe alternative strategy to eliminate onchocerciasis where the related filaria, Loa loa is co-endemic in Central Africa.We have pre-clinical data from efficacy screens and pharmacokinetic-pharmacodynamic modelling that positions the registered antibiotic, fusidic acid (FA) at the late laboratory validation stage as a potential seven day macrofilaricide drug cure, via targeting the Onchocerca filarial symbiont, Wolbachia.We propose to advance FA into clinical testing. We will undertake dose ranging to assess FA systemic exposures and safety in a Cameroonian onchocerciasis target population aligned with acceptable delivery (once, or twice daily dosing, maximum 14 days). We will establish exploratory efficacy proof-of-concept utilising early endpoint indicators of Wolbachia depletions within female O. volvulus and impact on embryogenesis compared against a 4-week doxycycline gold-standard treatment comparator, six months post-treatment. The major output of FAME will b