RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'DNA Vaccination Against Chronic Inflammatory Diseases' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The general objective of the current proposal is to exploit DNA vaccination as a treatment modality for chronic inflammatory diseases including autoimmune diseases and tuberculosis. It is increasingly realized that protective immunity against infectious diseases depends on immune recognition of 'altered self'. Many of the prominent microbial antigens seen in infection are now known to be highly conserved or homologous with mammalian protein antigens. Using DNA vaccination it has been demonstrated in an animal model that at least three mycobacterial antigens can be protective against tuberculosis infection. Two of these mycobacterial antigens are highly conserved heat shock proteins known to be cross-reactive with the mammalian homolgues. One of them, hsp650, is implicated and extensively studied in the aetiology of autoimmune arthritis, diabetes and a variety of other diseases with a presumed autoimmune component. Hence this antigen presents an ideal model to test ways of manipulating DNA vaccines to selectively favor the development of either anti-autoimmune or antimicrobial responses or both. In this project we propose to develop a transdisease vaccination technology for the treatment of chronic inflammatory conditions. To meet the overall objective of this research project, we propose to execute a research plan that can roughly be divided in three tasks, each with a measurable objective.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Fast Assay for Pathogen Identification and Characterisation' (FAPIC), addressing dissemination and exploitation.

assistant: **Impact**

The emergence of highly diverse resistance mechanisms among pathogens requires their detailed analysis to guarantee an efficient medical treatment. The gold standard in clinical diagnostics is based on the cultivation of bacteria and their phenotypical characterisation. However, these methods are labour-intensive and time-consuming lasting in some cases up to a few weeks. Thus, faster diagnostic techniques are necessary to ensure an immediate and targeted treatment of the patient. DNA-based diagnostics can provide the relevant results within a few hours.The requirements for a clinical DNA-based characterisation method are high; more than 1000 clinically relevant antibiotic resistance genes, a few hundred phylogenetic marker genes and virulence factors have to be targeted (including SNP detection). The limit of detection has to be low because a few 100 bacterial cells in the blood system can lead to the death of the patient. It should be possible to analyse a wide range of clinical sample origins such as stool, blood, urine and saliva using the same test. In addition, the results have to be obtained within a single working day. In our project, we will develop two diagnostic systems that can be with direct sample material from patients. Thus, the time-consuming cultivation of pathogens will be avoided. Additionally, the test will be more sensitive, specific and faster than any other test on the market using an innovative DNA probe concept.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel Fish Pathogens of the Chlamydiae: Genomic, Proteomic and Metabolomic Investigations' (CHLAFISH) under Seventh Framework.

assistant: **Objectives**

Chlamydia trachomatis is a devastating human pathogen, causing blindness, infertility and systemic disease; related Chlamydia bacteria cause respiratory infections and pre-term abortions in other vertebrates. These bacteria all have an intricate intracellular lifecycle. Recent in depth genomic studies on Chlamydia trachomatis have provided insights into how this species uses recombination to increase its potential for diversity. Recent studies in fish, both wild and farmed, have discovered new, related pathogens within the phylum Chlamydiae. The presence of these infectious bacteria impacts on the health of fish in aquaculture, which is a growing industry of key importance for meeting global food demands.  Further studies into these emerging pathogens are required.  We propose to perform large scale genomic analyses similar to those used with other Chlamydia species, using novel bacterial isolation technologies and high throughput sequencing. We aim to characterise selected strains using state of the art proteomics and metabolomics technologies.  We also aim to develop methods for growing these currently uncultured bacteria, to allow further investigations in vitro. These aims can only be achieved through a combination of the expertise of the researcher, and the technology and background knowledge of the host institution. The researcher brings genomic experience, and a newly developed bacterial isolation technique, and will receive training in novel methodologies to complement existing skills. Both the researcher and host will provide collaborations for the project, including new intra-European and global contacts.  Through this process we aim to get a greater insight into the evolution and diversity of these fascinating intracellular bacteria, to learn more about their
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Embedded electronically steerable satcom airborne antenna' to be submitted under Horizon 2020.

assistant: **Abstract**

E2S2A2 includes the design, prototyping, manufacturing and testing ""on ground"" and ""in-flight"" of an airborne antenna highly integrated into the wing – fuselage airframe fairing.  Allowing high data rate in-flight connectivity (IFC) for different purposes. The connectivity will be through satellite communication operating at the Ka frequency band. The antenna is electronically steered utilizing Phased Array technology. This allows the high integration into the airframe structure, concretely the wing-to-fuselage fairing (WFF) panels of the FTB2 prototype aircraft (A/C). The panels will be replaced by new composite structures with embedded antenna elements.  The antenna builds on concepts and prototypes developed by Gilat and its Bulgarian subsidiary Raysat and will benefit from the vast experience in SATCOM technology and airborne applications. The antenna consists of innovative Monolithic Microwave Integrated Circuit (MMIC) resulting from RTD partially funded by national RTD programs. The activities and 69 months' work plan are in accordance with the work plan of the Regional Aircraft FTB2 demonstrator. Close synchronization, coordination and cooperation with the Leader is vital. The work is divided into 6 technological WPs starting with the Definition of Structure and System Conceptual Design (WP1). WP2,3 include the activities from design to qualification of the Embedded Steering Antenna Aperture and KRFU unit (WP2) and the Ka Data Network Unit (WP3). The SATCOM MODEM selection and modifications will be carried through WP4. The SATCOM Ka band Antenna System Integration Activities at Laboratory level included in WP5. Integration into the A/C and ground and in-flight testing in WP6. WP0 is project management including close synchronization with the Leader and report
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'HIgh power and VOltage operation of electric MOTors in aeronautics', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The present proposal tries to answer in the best way the call JTI-CS2-2020-CfP11-THT-12. After the analysis of the call, our understanding of the objectives requested by the call is the following:The main objective of the project is to investigate solutions for the scientific and technical challenges regarding the use of high voltage high power electric drives at high altitude conditions. Both short and long term timeframes are contemplated, so research into the implications of high voltage and altitude in the reliability and safety of actual systems and its technical solution, but also investigation into new HTS based electric drives for these conditions are proposed.For this purpose, this main objective splits into the following technical objectives:•Investigation on modelling of high voltage electrical systems at high altitude for fundamental understanding of the technical issues related to inverter-fed HV insulation and arcing effects in electrical machines.•Research into insulation approaches and assessment of their reliability and safety at high altitude conditions.•Electromagnetic, electrical, thermal and mechanical design of actual topologies of electrical machines in order to evaluate the limits of each technology for high power and high voltage operation in aircraft applications.•Comparison of available and foreseen HTS materials for their use in electric machines for high volumetric and mass power density.•Investigation on thermal management systems for cryo-cooled HTS windings for electric machines in aircraft environment.•Preliminary design and comparison of different HTS based electric machine topologies for aircraft applications at high voltage and high altitude in terms of power density, reliability and safety.•Full design of a HTS electric motor concept
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Molecular characterization of the interaction of β -2 microglobulin with collagen'.

assistant: **Objectives**

β -2 microglobulin (β-2-m) is a 99 residue protein with an immunoglobulin fold. β-2-m is usually found as a part of the major histocompatibility 1 complex. This protein aggregates to form amyloid fibrils in osteoarticular tissues, leading to pathological bone destruction and the condition known as dialysis-related amyloidosis (DRA). The accumulation of β-2-m deposits has been shown to cause arthralgias, destructive osteoarthropaties and carpal tunnel syndrome.  The host laboratory has characterized β-2-m amyloid assembly and developed a molecular description of the folding and aggregation mechanisms of β-2-m under relevant conditions, but the factor or factors responsible of the initiation of the aggregation process are still unknown.β-2-m amyloid accumulates in connective tissue, causing the pathological consequences of the disease. Collagen is one of the main components of this tissue and has been proposed to be a possible contributing factor in the initiation of aggregation.  Consistent with this, studies with ex vivo amyloid material show that there is a strict association between β-2-m and collagen within joints, while biochemical experiments have revealed tight binding between β-2-m and collagen.This project will focus on the study of the interactions between collagen and β-2-m and its consequences for the formation of amyloid fibrils from a molecular viewpoint. We will study the specificity of interaction of β-2-m with different collagen sequence patterns and the influence of collagen on β-2-m stability, dynamics, and aggregation rate. For this project a complementary set of biophysical techniques, including mass spectroscometry, NMR, fluorescence, infrared spectroscopy and electron microscopy, will be used. The results will facilitate the design of small molecul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Understanding the virtual: integrated evaluation of ICT applications in museums'.

assistant: **Concept**

An investigation of the contribution of ICT and particularly Virtual Reality (VR) applications in museums related to cultural heritage through the evaluation of several examples, taking into account all the elements involved (the interface, the social dimension and the message). The analysis is aimed at building a body of empirical knowledge and at developing a standard evaluation methodology in order to provide guidelines for the use of VR as a communication tool in museums and archaeological presentations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cerebral organoids: human mini brains in a dish open up new possibilities for drug development in neurodegenerative and developmental diseases' under Horizon 2020.

assistant: **Concept**

Transferring results from animal models to humans is a major bottleneck in pharmaceutical research. This is particularly true for brain disorders, including neurodegenerative and developmental diseases. Both animal models and conventional cell culture methods fail to recapitulate the complexity of the human brain and there are fundamental differences in developmental and physiological aspects between humans and the commonly used animal models. The high attrition rate of drugs for brain disorders has led major pharmaceutical companies to severely downsize their respective departments. To overcome the inherent limitations of current in vitro and in vivo models for brain disorders, we have generated a proprietary human pluripotent stem cell-derived 3D organoid culture system, termed cerebral organoids. These cerebral organoids are ‘mini brains’ that grow in a petri dish , display discrete but interconnected brain regions and recapitulate features of human brain development. ‘Mini Brains’ can be derived from patient-specific stem cells and represent a unique opportunity for creating specific human disease models in a 3D culture. The aim of the ‘Mini Brain’ project is to investigate the commercial feasibility of cerebral organoids as a new and highly cost-effective tool in the discovery and development of therapies for neurodegenerative and developmental diseases. The use of patient-specific cerebral organoids for drug screening and validation offers an alternative to animal experiments, reducing costs and animal use and improving reliability of results, and has the potential to decrease the cost of drug development, reduce the brain disease burden and increase the rate of approved drugs for brain disorders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A cybersecurity situational awareness and information sharing solution for local public administrations based on advanced big data analysis' to be submitted under Horizon 2020.

assistant: **Abstract**

Cybersecurity is one of today's most challenging security problems for commercial companies, NGOs, governmental institutions as well as individuals. Reaching beyond the technology focused boundaries of classical information technology (IT) security, cybersecurity includes organizational and behavioural aspects of IT systems and also needs to comply to the currently actively developing legal and regulatory framework for cybersecurity. For example, the European Union recently passed the Network and Information Security (NIS) directive that obliges member states to get in line with the EU strategy. While large corporations might have the resources to follow those developments and bring their IT infrastructure and services in line with the requirements, the burden for smaller organizations like local public administration will be substantial and the required resources might not be available.New and innovative solutions that will help local public administration to ease the burden of being in line with cybersecurity requirements are needed. For example, cooperation and coordination is one of the major aspects of the NIS and EU cybersecurity strategy. An enabling technology for cooperation and coordination is cyber situational awareness and information sharing of cyber incidents. In this project we propose a cybersecurity situational awareness solution for local public administrations that, based on an analysis of the context provides automatic incident detection and visualization, and enables information exchange with relevant national and EU level NIS authorities like CERTs. Advanced features like system self-healing based on the situational awareness technologies, and multi-lingual semantics support to account for language barriers in the EU context, are part of the soluti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Merging Lie perturbation theory and Taylor Differential algebra to address space debris challenges' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

In an increasingly saturated space about the Earth, aerospace engineers confront the mathematical problem of accurately predicting the position of Earth’s artificial satellites. This is required not only for the correct operation of satellites, but also for preserving the integrity of space assets and the services they provide to citizens. Operational satellites are threatened by the possibility of a collision with a defunct satellite, but most probably by the impact with other uncontrolled man-made space objects—all of them commonly called space debris.The present international concern in space situational awareness (SSA) has produced a renewed interest in analytical and semi-analytical theories for the fast and efficient propagation of catalogs of data.  Within this framework, it is widely accepted by experts that perturbation theory based on Lie transforms is the most accurate and efficient method to derive semi-analytical propagators.  In a semi-analytical approach, the highest frequencies of the motion are filtered analytically via averaging procedures, allowing the numerical integration of the averaged system to proceed with very long step sizes. Then, the short-period terms can be recovered analytically.Another fundamental need in SSA is the efficient management of uncertainties that characterize the motion of orbiting objects. To this aim Taylor differential algebraic (DA) and Taylor model (TM) techniques have been transferred in the last decade from beam physics field to astrodynamics. These techniques, by allowing high order expansions of the flow of the dynamics and rigorous estimate of the associated approximation errors, have shown to be a powerful tool for managing uncertainties both in initial conditions and model parameters.The focus of this project is t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Health, safety and ErGOnomics for the future human-centric factory' (HEGO) under Horizon Europe.

assistant: **Objectives**

MSDs are inflammatory and/or degenerative ailments affecting all sectors and all categories of workers, and are by far the most common work-related health problem in the European industry. The biggest Europe-wide occupational health survey found 46% of European workers reporting back pain, while 43% had painful shoulder, neck and upper limb muscles. The social and economic consequences of this “pandemic” are now becoming clear: •MSDs accounted for 53% of work-related diseases in the EU-15, affecting 100 million people and causing half the absences from work and 60% of permanent work incapacity.•Total cost of lost productivity attributable to MSDs is 2% of gross domestic product in the EU (€240 billion).HEGO is an innovative solution based on a proprietary set of Motion Capture algorithms able to recognize the workers’ gender, age, posture and movements in real-time and monitor ergonomics to adapt both workspace and workload according to worker’s personal profile, to inform about potential MSDs risks, and to provide insights for improving the work environments. Without the use of wearable devices and thanks to an automatic analysis of ergonomic risk factors, HEGO can detect any incorrect posture of the worker or risky situations, suggesting to operators the corrective actions. The performance of the system is outstanding and has been validated in industrial facilities: accuracy in recognition of skeleton points and movements > 85%; true positives and true negative in the recognition of an incorrect posture > 90%; data synchronization times < 0.5 sec. HEGO contributes to promote health and safety in industrial workplaces (Human-centered manufacturing concept) by providing a low cost and reliable solution.


**Keywords:** Motion Capture models,  health and safety in indust