RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel Stromal Cell Therapy for Diabetic Kidney Disease' (NEPHSTROM) targeting Horizon 2020.

assistant: **Abstract**

Type 2 diabetes will affect >500 million adults by 2040 and its secondary complications will generate enormous socioeconomic costs - in particular, diabetic kidney disease (DKD), which is already the most common cause of chronic kidney disease. DKD is associated with greatly increased mortality and frequently progresses to end stage renal failure. Pharmacotherapy, dialysis and transplantation represent the mainstay treatments for DKD but are costly and provide only limited protection against adverse outcomes. Mesenchymal Stromal Cell (MSC) therapy is a promising approach to halting the progression of DKD toward end-stage renal failure and may also have ancillarybenefits in Type 2 diabetes. In preliminary research, we have demonstrated that a single dose of MSC simultaneously improves kidney function (glomerular filtration rate and albuminuria) as well as hyperglycaemia in animals with DKD. NEPHSTROM will conduct a multi-centre, placebo-controlled clinical trial of a novel MSC therapy for stabilization of progressive DKD, leading to superior clinical outcomes and long-term socioeconomic benefit. Akey enabler for this trial is a novel MSC population (CD362+MSC, trade name ORBCEL-M) which delivers higher purity and improved characterisation compared to conventional plastic-adherent MSC. The NEPHSTROM Phase 1b/2a clinical trial will investigate the safety, tolerability and preliminary efficacy of a single intravenous infusion of allogeneic ORBCEL-M versus placebo in adults with progressive DKD. NEPHSTROM investigators will also determine the bio-distribution, mechanisms of action, immunological effects and economic impacts associated with ORBCEL-M therapy for DKD. This research will critically inform the optimal design of subsequent Phase 3 trials of ORBCEL-M. Stabilising p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The genomic adaptations to cope with unpredictable climates over the course of life' (ClimAdaptLife), addressing dissemination and exploitation.

assistant: **Impact**

Increasing climatic fluctuations mean that animals need to evolve increased heat resilience whilst simultaneously coping with cold periods throughout their lives. Large animals are particularly susceptible to temperature fluctuations as their large size when mature exposes them to heat stress, and their small size when juvenile exposes them to cold stress. I will test two hypotheses that are central to understanding how large species evolve to cope with temperature fluctuations: 1) Genomic adaptations that increase heat resilience compromise cold resilience. 2) Genes that increase thermal resilience during early life have opposing effects on thermal resilience later in life. Testing these hypotheses requires identifying the genomic basis of thermal resilience. This has remained elusive in large animals because of difficulties in 1) rearing high numbers of large animals, 2) exposing them to natural temperature fluctuations and 3) obtaining measurements of fitness related traits such as growth of juveniles and reproduction of adults. I will solve these issues by studying the largest bird on Earth, the ostrich, monitored in large numbers under natural temperature conditions. This will allow me to take an interdisciplinary approach combining body temperature measurements and cutting-edge genotyping of 2000 juveniles and adults. A close partnership with a South African research station will enable me to utilise data of growth and reproduction of 11700 juveniles and 1800 adults exposed to the natural climate over 25 years. To test the importance of identified genes for local climatic adaptation I will genotype natural populations of ostriches across climatic gradients. My work will resolve how genes conferring resilience to heat influence the ability to cope with cold, and if
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Fourth International Conference on Home and Community Care for Persons Living with HIV/AIDS' in the context of a Fifth Framework call.

assistant: **Objectives**

The object of the 4th Conference 'Paris HIV 99' is to create a forum for dialogue to share experiences and exchange concept in order to:- originate and encourage networks and alliances within and amongst industrialised and developing countries;- facilitate the involvement of people living with HIV/AIDS in the creation and implementation of care projects and daily support - promote the participation of volunteer and family nursing staff;- improve home and community care by means of community and volunteers participation;- mobilise and promote individuals'rights;- advance the recruitment, training and support for researchers, volunteers, and professionals;- provide and opportunity for international and no-governmental organisations to explore existing and new strategies and models in response to the needs of the those infected and affected in view of new scientific and technical developments;- promote an effective role of community groups in administrative aspects when dealing with decision-making authorities at every level.The conference is built on six main themes:1. Medical aspects of home and community care;2. Psychosocial aspects and support for home and community care;3. The role of community and self-support groups in home and community care;4. Ethics and human rights in home and community care;5. Monitoring and evaluating the quality of home and community care services and programmes;6. Care, care-givers and home care.'Paris HIV 99' is unique in that conference, unlike others, whether international AIDS conventions or specific symposiums of the clinical or bio-psychological aspects of epidemic, provides and exemplary and adequate forum for the discussion and development of home and community care.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00214-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Investigation, Revival and Optimisation of Traditional Mediterranean Colouring Technology for the Conservation of the Cultural Heritage' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Colouring or painting with natural dyeing materials has been fundamental in art and intrinsic to the cultural identity of the Mediterranean area, since antiquity. However, since mid 19th century synthetic substances almost entirely expelled natural dyes fr om the market. The reconstruction and revival of traditional manufacturing processes for natural colorants, as well as of dyeing procedures or painting techniques is essential for the preservation of the Mediterranean cultural heritage. Rationally produced natural dyes can be used for artworks and folk applied art crafts, and this can also invest to the creation of new jobs, introducing a social-economic impact on the quality of human life. Furthermore, developing environmentally more acceptable products is a positive action towards the ecosystem. The proposal implies several coordinated activities, such as: (i) Analytical study of representative artworks/artefacts as far as the identification of the organic colouring materials, and the technology of their a pplication is concerned. (ii) Practical revival/approbation of reconstructed application techniques/technologies of the dyes and derived organic pigments on several substrates, e.g. textile, paper and paintings, for the creation of artefacts according to a ncient recipes. (iii) Optimisation of the application techniques through the investigation of interrelation between application physicochemical conditions and final result in terms of colour hue, strength and fastness. (iv) Synthesis and production of majo r colouring components, utilized as standards for dyestuff identification, at a molecular level. (v) Dissemination of the newly produced materials (pigments and standards). (vi) Recommendations for conservation strategies, based on the analytical results. (vii
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Short, weakly interacting RNA ligands for the development of high-concentration monoclonal antibody therapeutics' (SWIRL).

assistant: **Innovation**

Usage of therapeutic monoclonal antibodies (mAbs) has over the past 20 years become one of the most powerful pharmacological strategies in the treatment of various types of cancer, cardiovascular diseases and autoimmune disorders. Importantly, a central challenge in developing the required high protein concentration formulations of mAb therapeutics is the issue of protein solubility. The current approaches for addressing this challenge typically involve using different osmolyte excipients such as salts, carbohydrates, amino acids or surfactants, but they suffer from various problems including insufficient activity, low specificity, allergenic reactivity and others. Clearly, there exists an unmet need for novel strategies to increase the solubility of mAbs in pharmaceutical formulations in an efficient, cost-effective, target-specific manner. We propose to address this challenge by exploiting one of the central biological interaction partners of proteins, the RNA molecules. Specifically, we will: 1) bring to a product stage a computational software suite for designing short, weakly interacting RNA ligands (SWIRLs) that improve the solubility of aggregation-prone mAb therapeutics in a sequence- specific manner, and 2) commercialize the software for usage in a biopharmaceutical context. The designed SWIRLs increase the solubility of target proteins and shield them from unwanted aggregation through weak, specific interactions and a simultaneous alteration of solvent structure. Moreover, a major advantage of using short, standard unmodified RNAs is that they are non-immunogenic and are degradable in the blood, which makes them a unique material for formulation development. Importantly, the sequence-specific design of SWIRLs for a particular target protein will be based on fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Beam Shaping in Complex Systems' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The objective of this proposal is to devise new ways of shaping light and other electromagnetic waves in complex and novel structures. The research will delve into fundamental aspects of electrodynamics, from classical optics to the quantum mechanical dynamics of photons.Over the past twenty years, several new kinds of artificial media for electromagnetic waves were demonstrated, among them photonic crystals, metamaterials, plasmonic materials, and more recently graphene-like photonic lattices. These new kinds of ""electromagnetic media"" call for new methods for beam shaping to facilitate control over the electromagnetic fields propagating within them. Moreover, many novel photonic systems and devices rely on strong coupling between light and matter. Naturally, such systems combine quantum mechanics effects with classical electrodynamics. For example, modern experimental research would greatly benefit from efficient coupling of light to quantum dots, nano-photonic structures embedded in silicon chips, or particular molecules – to manipulate and probe the molecular dynamics. All of these necessitate novel methods for shaping light in new kinds of structures, which cannot be addressed by traditional techniques.In this research plan, I aspire to make fundamental theoretical contributions that, apart from their basic research component, will also contribute to a large variety of present and future applications. I believe this ambitious research will have high impact, advancing the knowledge on waves' propagation in structured media, which is at the forefront of current research.The outgoing phase (first two years) will take place at Stanford, under the supervision of Prof. Shanhui Fan. The return phase (third year) will take place at the Technion, under the supervision of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Synthesis and characterization of hyperbranched and dendrimeric aromatic polyamides'.

assistant: **Objectives**

Synthetic polymer structures consisting of highly branched macromolecules (dendri- mers and hyperbranched polymers) have recently sparked considerable attention for their unusual behaviour and properties. Among them, rigid structures originated from aromatic monomers show peculiar globular shapes, which have a major effect on their basic physical and chemical properties. The present project centred on the direct synthesis of hyperbranched aromatic po- lyamides using the modified Yamazaki's method. Final objective of the project is to synthesize and characterize Kevlar-type dendrimeric polymers built with a fra- ctal-like architecture, thus resulting in a highly symmetrical structure leading to dense packing of the surface. Potential applications of these structures in va- rious fields will also be explored. In order to reach the above goal it is necessary: 1) to define the synthetic route to the multifunctional monomers, 2) to optimize the polymerisation conditions, and 3) to characterize the molecular structure and the most relevant properties of the resultant dendrimeric macromolecule.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Emergence In the Loop: simulating the two way dynamics of norm innovation' (EMIL), addressing dissemination and exploitation.

assistant: **Impact**

The main objective of this project is to understand and develop design strategies able to cope with the complex 2-way dynamics of sociality, consisting of emergent and immergent processes: from interaction among individual agents to aggregate level, and immergence of entities (norms) at the aggregate level into agents' minds.In particular, we plan to focus on norm innovation. As research priorities, besides dealing with incompleteness and uncertainty, we intend to contribute to the understanding and description of hierarchic systems by describing agents acting on multiple, i.e. individual, communitarian and institutional levels.As to understanding of distributed processes in IT, the project is aimed at modelling the interactive, bidirectional processes of emergence:A summary of main theoretical goals is:- understand and manage complexity in social systems with autonomous agents;- understand how new conventions and norms emerge and spread in these systems;- study of norm innovation by means of agent-based simulation.The main technological aim of the project is to construct a simulator for exploring and experimenting upon norm-innovation. Concerning the applicative side, we intend to contribute to the regulation of e-communities by handing out a simulator for the emergence of new norms in complex social systems, where situated experiments can be run. While the simulator will be designed as a general-purpose tool, a specific study case will be selected as so to provide the necessary grounding parameters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Genetics of male traits and female preferences and their role in sympatric speciation'.

assistant: **Innovation**

Research objectives and content Traditionally speciation is understood as a by-product of divergent evolution in geographical isolation. Recent empirical observations and population genetical models, however, suggest that symaptric speciation by sexual selection may be a process that significantly shapes evolution of animal diversity. The objectives of this project are: (1) to determine the genetics of mate preferences and preferred traits in a model system (African cichlid fish) by cross- breeding and selection experiments (2) to determine effects of environmental conditions (light) on sexual selection by mate choice experiments and subsequent paternity analysis. (3) The genetical parameter values will be incorporated in an existing stochastic simulation model. Output of the model,and results of paternity analysis will be analysed against a background of existing data on colour and species diversityalong gradients of light conditions. The results will contribute to understanding how genes, behaviour and environment interact in sexual selection, and sympatric speciation. Training content (objective, benefit and expected impact) Objective: development of skills (1) in population genetical modeling and (2) in application of molecular techniques to population genetical problems. Obtaining research experience in these fields will add to my skills in a very much complementary way and will greatly increase my competitiveness as an evolutionary biologist. Having obtained these skills I feel I will be well equipped to set up a research programmein evolutionary biology wherever I may find employment after my postdoc. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Aeronautics ERA-Net as one of the key enablers of the prosperous development of Aeronautics in Europe' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The air transport industry is large, important and complex. It makes a massive contribution to the prosperity of Europe, both in terms of a globally competitive manufacturing sector providing goods and services, and also in terms of promoting the effective transfer of people and goods within Europe and globally. Achieving the objectives in Aeronautics is critically dependent upon major aeronautical research and technological advances in the medium to long-term. The prosperous development of Aeronautics In Europe also depends upon key enablers such as improving the coherence and co-ordination of aeronautical research and innovation activities conducted at national and European levels. GARTEUR (a government-to-government agreement between France, Germany, Italy, the Netherlands, Spain, Sweden and the United Kingdom to strengthen co-operation in aeronautics) and the proposed ERA-Net in Aeronautics, the Air Transport Net (AirTN), are examples of those key enablers. The objectives of the proposed AirTN (Aeronautics ERA-Net) are twofold: (1) to step up the co?? operation and co-ordination of research activities in aeronautics carried out at national level through the networking of research activities at EU level; (2) to expand the European dimension with an aeronautical network in order to improve the coherence and co-ordination of aeronautics and in order to strengthen the underpinning of the European Aeronautics programme. These two objectives will be achieved by bringing together key actors (public bodies and other national bodies that finance aeronautical research activities) from a large number of European nations (sixteen Member States plus Romania and Switzerland) with a common strategic interest in Aeronautics. These key actors will form AirTN and will carry out the p