RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fibroblasts in the Biology of Rectal Cancer Progression' to be submitted under Horizon 2020.

assistant: **Abstract**

Although the therapeutic strategies adopted in the last years for the clinical management of patients with rectal cancer have improved patient’s quality of life, tumor relapse still constitutes to be a factor that determines patient survival. These patients, usually treated with chemo-radiotherapy (CRT), often develop a CRT-induced fibrosis, which is characterized by an overgrowth of fibroblasts at tumor-treated areas. The importance of tumor stroma for the development, progression and invasion of cancer is increasingly gaining weight, however, the biological basis of fibrosis, as well as the consequences that it has in terms of therapy resistance and tumor relapse remain unknown. The major objective of this proposal is to understand the effect of CRT on fibroblasts and its consequences on tumor relapse and formation of distant metastasis. To reach this, we propose a multidisciplinary approach that combines the analysis of unique patient-derived biological samples using innovative and advanced techniques in molecular and cell biology. More specifically, using a proteomic approach and primary cultures of fibroblasts derived from rectal tumors taken before and after CRT from the same patient, we will determine the effect of CRT on the molecular alterations in fibroblasts. Then, using 3D in vitro models we will determine if CRT-derived fibroblasts play a role in therapy resistance, proliferation and invasion of cancer cells, while ortothopic mouse models will be used to test if CRT-derived fibroblasts can trigger rectal cancer progression and metastasis. Finally, using previously collected clinical data of rectal cancer patients we will analyze if tumor relapse is related to the appearance of fibrosis and, if it has a positive or negative prognosis valueAltogether, the res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Analysis of the role of notch-delta signalling during somite formation in the paraxial mesoderm' (1994-1998).

assistant: **Concept**

Research objectives and content Differentiation of somites into specific cell lineages is regulated by inducing signals derived from the local environment. The cellular and molecular interactions that are involved in patterning newly formed somites have been well documented. However, the paraxial mesoderm does not respond to these signals prior to somite formation. It is not clear what molecular mechanisms regulate, firstly, the competence of the paraxial mesoderm to respond to extrinsic sources of inducing signals, and secondly, the process of paraxial mesoderm segmentation. The aim of this project will be to define these molecular signals using both in vivo and in vitro systems. The Notch and Delta genes have been implicated in the specification of cell fate during neurogenesis and mesoderm formation in Drosophila. Three mouse homologues of these genes, Notch-l, Delta-l (which have also been identified in the chick) and the recently identified mouse Delta-3 gene, are expressed in the presomitic mesoderm. Initially, a PCR approach will be used to isolate the avian homologue of the mouse Delta-3 gene. The role of Notch-Delta signalling in somite formation and the development of competence to respond to inducing signals, will then be investigated using avian retroviral constructs of the Delta genes coupled to in vivo and in vitro approaches. Training content (objective, benefit and expected impact) During this post-doctoral project I will be using a molecular approach to understanding the role of signalling molecules in the developing paraxial mesoderm thus expanding my repertoire of skills using a PCR approach to isolate specific signalling molecules I will address their role in paraxial mesoderm by use of retroviral constructs. Links with industry / industrial relevanc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Medium to long term thermal energy storage system with embedded heat pumping capability' in the context of a Horizon Europe call.

assistant: **Objectives**

The use of intermittent energy sources such as wind and solar incur fluctuations in energy production which lead to gaps in renewable energy availability. Using electricity at peak production to generate thermal energy becomes feasible only if thermal energy storage provides means to decouple generation from production. Many industrial processes generate large amounts of thermal energy throughout the year as waste heat which reduces energy efficiency. In some industrial setups, waste thermal energy is rerouted in industrial parks, however, temperature levels, demand schedule and processes proximity rarely play in favour of this circular approach. Sector coupling opportunities are reduced due to a mismatch between sector demand schedules. To address these challenges our main objective is to develop a medium-temperature, medium-to-long-term Thermal Energy Storage System (TESS) with built in heat-pump capabilities provided by a hybrid approach using TCM & PCM materials. Based on our preliminary analysis we aim to achieve a round trip efficiency for power-to-storage-to-heat or heat-to-storage-to-heat of 140-160% depending on temperature level with a storage density of 0.5 GJ/m³ at lab-scale level, while addressing cost-effectiveness. At material level we aim for a 20% increase in energy density, while using sustainable and affordable materials and production methods. By addressing industrial applications, the current project aims at decarbonising the third most emitting sector in the EU - manufacturing, which is responsible for ~20% of the total GHG emissions in the EU. Developing a versatile and energy dense TESS facilitates deployment within the industrial sector, further enhancing sector coupling capabilities such as cascading industry sectors or coupling industrial park
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ultracold polyatomic molecules for controlled chemistry and precision physics' in the context of a Horizon Europe call.

assistant: **Objectives**

Ultracold atoms have been successfully used in quantum simulations and precision measurements. Molecules possess a richer internal structure promising new applications. However, only relatively simple molecules have been produced and employed at ultralow temperatures. This project aims to understand and harness the increasing complexity of ultracold polyatomic molecules to probe the fundamentals of chemistry and physics.We will extend the range of ultracold polyatomic molecules and their applications in controlled chemistry and precision spectroscopy. We will propose and theoretically investigate two paths: 1) association of ultracold deeply-bound diatomic molecules into ultracold weakly-bound polyatomic molecules and 2) direct cooling deeply-bound polyatomic molecules carefully selected and manipulated with electromagnetic fields. The first approach will build on established atomic techniques, which we will extend to molecular systems. The second one will employ strong fields, short pulses, and structural modifications to engineer closed transitions suitable for laser cooling. We will combine and develop novel electronic structure and quantum scattering methods enhanced by machine learning and high-performance computing. Next, we will study new applications exploiting features emerging from single-molecule and coherent control, conical intersections, and non-trivial electronic states and geometries absent in simpler systems. Applications will range from quantum-controlled chemical reactions and molecular dynamics to precision measurements of fundamental constants and their spatio-temporal variation. The realization of the project will push cold chemistry into the quantum realm and bring unprecedented complexity to ultracold physics, thus, give new insights into the phy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The role of visual cues in speech segmentation and the acquisition of word order: a study of  monolingual and bilingual adults and infants' (VISCUESACQWO), addressing dissemination and exploitation.

assistant: **Impact**

Adults and infants make use of both auditory and visual information in speech perception. The available visual cues include oral-articulatory movements (e.g., lip movements), as well as non-verbal gestures (e.g., head-movements). The present project seeks to investigate the role of visual cues as an aid for auditory prosody in speech segmentation and in bootstrapping syntactic development, topic that remains as yet unexplored. The present project focuses on a type of prosodic information, i.e., the acoustic realization of phrasal prominence, which has been proposed to potentially allow prelexical infants bootstrap the basic word order of the target language, a major syntactic property of natural languages. Phrasal prominence correlates systematically with word order, i.e., it is realized by means of pitch changes in OV languages, and changes in duration in VO languages. The series of experiments here presented aim to: (i) identify and measure the visual cues—facial gestures—that potentially accompany the prosodic cues—changes in pitch and duration—correlated with word order differences, and (ii) examine whether visual cues modulate or determine the segmentation preferences of adult and infant monolinguals and bilinguals of an unknown language that additionally contains prosodic cues. In a series of artificial language learning experiments participants will be familiarized with artificial languages that contain either matching or mismatching auditory and visual cues—which will displayed by means of a computer-animated avatar—and will be subsequently tested on their segmentation preferences. This research will advance our understanding of the role of visual facial information in speech processing, as well as of the cognitive mechanisms involved in the acquisition of synta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Interdisciplinary Strategic Intelligence wareHouse and Think-tank for Energy' (2007-2013).

assistant: **Innovation**

As today’s energy policy decisions are not only very complex, but also fundamentally political decisions, the necessity to build them on sound, unbiased and up-to-date information/knowledge makes energy policy analysis and advice from a broad array of non-commercial actors key to effective policy formulation. Taking this into account, it is the aim of this project to establish a multidisciplinary and independent energy think tank consisting of experts from the energy sector, top researchers, engineers, leading trade, economic, environmental, and legal experts who are experienced in delivering high quality policy advice and impact assessments. The think tank will provide policy makers at the European level with objective and unbiased policy advice as well as insights on policy options, including an assessment of their potential impact. Moreover, the think tank will bring to the attention of political decision-makers new trends in technology as well as the objectives and activities of important stakeholders that shape energy policy-making in Europe. In order to assess policy options concerning the four dimensions of sustainability (environmental, economic, social, institutional), the project will use an integrated assessment framework, backed by high-quality data resources available to the project consortium. To complement this, the project will establish innovative methods of stakeholder engagement and trend identification through the establishment of an ‘Energy Observatory’. Moreover, with transparency being of significant value, INSIGHT_E will make its models, assumptions, and scenarios available through a ‘Scenario Information System’. Implementing a flexible and at the same time profound information tool will bring about significant improvements to the policy making
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Protein Adsorption onTo CHarged surfacES' (PATCHES).

assistant: **Concept**

Biocompatibility of medical implants and devices is of paramount importance for their safety, effectiveness, and utility. The release of medical devices that are not biocompatible and biodurable is still an issue (for instance, more than 100.000 European patients are implanted with Metal-on-Metal hip joints which have been found toxic under specific circumstances), which has recently resulted in a proposal of the European Commission for the amendment of the Medical Device Directive.Biocompatible materials should be assessed based on their chemical, physical and toxicological properties as well as on their interaction with body fluids. A rapid adsorption of proteins on the foreign material will favour the anchorage of the cells, leading to safer and more durable medical implants/devices. Proteins adsorption is influenced by chemical and molecular structure characteristics and by the distribution of electric charges at the interface between surface and proteins. The distribution of surface charge has been so far attributed to the chemical reactions of the surfaces with body fluids. However, other aspects such as contact conditions and relative motions of surfaces have been recently appointed as crucial factors in the distribution of charge on the surface and thus on protein adsorptions. The proposed project will focus on the analysis of tribologically induced surface charge distribution on different biocompatible materials and on its impact on protein adsorption. This research will be conducted using Density Functional Theory (DFT) calculations and classical Molecular Dynamics (MD) simulation methods and the models will be validated by experimental tests. The project’s main goal is the design of a multi-scale hybrid computation/experimental methodology that will allow to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Designing Novel Phonon Valve Device through Ferroic Domain Wall Engineering'.

assistant: **Objectives**

Much of the major technological breakthroughs occurring in the last few decades rely on our enhanced capability to control and manipulate two particles: electrons (both charge and spin) and photons. Achieving a similar degree of control over phonons would be extraordinarily valuable as we will be able to channel thermal energy at will –thus propelling new possibilities for energy management– as well as the development of a completely novel technology for logic, data storage devices and computing mechanisms based on phonons.The goal of this proposal is to design a conceptually new device: a phonon valve, a nanostructured system to control phonon transport at will by an external field. To carry out this idea we propose to use ferroelectric oxide materials as valves, in particular engineering suitable configurations of ferroelectric-ferroelastic domain walls in multilayer nanostructures. If successful, the realization of this project would represent a major qualitative leap forward in an emerging new technology: “Phononics”. Moreover, it will contribute to progress in the field of physics and properties of ferroic domain walls.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of 3-d ice accretion modelling - heat transfer and droplet dynamics studies' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content The aim of the project is to develop techniques to simulate icing on aircraft surfaces. Current mathematical models have limitations due to the assumptions made in the heat transfer and droplet rebounds thus resulting in an incorrect prediction of ice shapes. The research studies shall consist of the following: 1. Experimental measurements of heat transfer on realistic ice shapes. This will be undertaken using hot film probes and naphthalene sublimation technique will be used to measure the convective heat transfer in a subsonic wind tunnel. A theoretical model will then be formulated into the appropriate form, to be incorporated into an existing ice prediction code. 2. Experimental measurements of water droplet rebounds.. A droplet generator will be designed to produce a continuous stream of water monodispersed droplets, which will collide, with specified targets in a subsonic wind tunnel. The rebound velocity and sizes will be recorded with a Phase Doppler Particle Anemometer. Theoretical models will be formulated to be incorporated into the ice prediction code. 3. Simulation of ice build-up on a NACA0012 aerofoil and comparison with experiments undertaken in an icing tunnel Advanced computational fluid dynamics techniques will be used together with the results of the experimental work to design an accurate 3-D ice accretion model Note: The intended programme complements a U.K. programme but looks at academic improvement to existing technologies which is over and above the contracted objectives already agreed. Training content (objective, benefit and expected impact) Short courses on Laser Anemometry (at UMIST-GB) and on CFD techniques (at VKI-BE) are planned as well as hands-on training on Phase Doppler Particle Anemometry at Rolls-Roy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Conservation and evolutionary genetics of avian malaria with reference to South Pacific Islands' under Sixth Framework.

assistant: **Concept**

Our ultimate goal in proposed study is to model the degree to which malaria and other diseases have invaded the southern Pacific Islands and an assessment of future risk to the remote Melanesian avifauna based on host colonization histories and current genetic diversity. Lack of epidemiological surveys makes it difficult to understand the wider distribution of the parasites and how it has been transmitted among islands. Members of the silvereye complex (Zosterops lateralis) provide a unique opportunity to study these questions.The Zosteropidae family contains more successful island colonizers than any other passerine group and in the southwestern Pacific members of the silvereye species complex have repeatedly invaded islands from the Australian mainland. The sequence and dates of colonization of islands have been historically documented and information in general dynamics of the population is also available.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Reinforcing the scientific excellence and innovation capacity in logistics technologies of the University of Miskolc'.

assistant: **Concept**

The overall aim of the UMi-TWINN project is to reinforce the scientific excellence and innovation capacity in logistic systems of the University of Miskolc (UMi) and its high-quality Twinning partners for the benefit of different industries and logistics market. To achieve this aim, the 3 year project will build upon the existing strong research and innovation base of UMi and its twinning partners Fraunhofer-Gesellschaft e.V. IFF (Fraunhofer), Technische Universitaet Graz (TUGraz) and Intelligentsia Consultants (Intelligentsia). The UMi-TWINN project aims to boost UMi and twinning partners' scientific excellence and innovation capacity in logistics technologies, as well as implementing a research and innovation strategy focused on three sub-topics:1.Design of logistic systems and networks; 2.Intelligent transport systems; 3.Dynamical analysis of materials handling machines.The research and innovation strategy takes into account the recent SWOT analysis of UMi as well as the national Hungarian research priorities and regional Smart Specialisation Strategy . The specific objectives of the UMi-TWINN project are presented below:Objective 1: Strengthen UMi’s research excellence in LogisticsObjective 2: Enhance the research and innovation capacity of UMi and Twinning partnersObjective 3: Raise the research profile of UMi and the Twinning PartnersObjective 4: Contribute to the research and innovation priorities of HungaryObjective 5: Support research and innovation on a European levelIn order to achieve these objectives, the consortium partners defined a comprehensive set of measures and activities implemented via the project’s work packages:* Short term staff exchanges* Training workshops, summer schools and conference* Dissemination and outreach activities


**Keywords:** lo