RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Instruments and networks for developing logistics towards sustainable territorial objectives'.

assistant: **Innovation**

INNESTO addresses the current dichotomy between the EU orientation towards sustainable regional development and the current approach to logistics in the European market. Conventional logistics does not consider social and environmental costs and is dominated by large companies that jeopardise the autonomy of SMEs, economic districts, social communities and local authorities. There is a lack of instruments for sustainable district logistics. INNESTO will elaborate a sustainable district logistics approach that: integrates the latest developments in material flows management, logistics and sustainable quality management; develops innovative methods and tools; builds local community capacity for innovating local development strategies; makes it possible to reduce all logistics related costs in a shorts, medium and long term perspective; assures the INNESTO continuity at European level after the conclusion of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Program for the renewable energies' (PEREMEETI).

assistant: **Innovation**

The aim of our project is to use, exploitation and dissemination of results from non-nuclear energy research, technological development and demonstration projects funded under the current 5th framework programmes. Our work programme must evaluate the needs of market actors and encourage them to use clean and efficient technologies. It must implement evaluation processes and analysis of results (performance indicators). It must promote information dissemination and provide a support for a national focal point for transnational actions. These objectives will be linked mainly with RUE and RES. It will be aimed at local authorities, housing and service sectors in France and in island regions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Tiam1-Rac signalling in lymphomagenesis' (TIAM1-JC-AG-2005), addressing dissemination and exploitation.

assistant: **Impact**

Background: Retrovirus-induced tumours acquire in time increasing numbers of proviruses in their genome, which are required for the activation of additional (onco)-genes that contribute to tumour progression.Insertional mutagenesis in oncogene-bearing transgenic mice is therefore a powerful strategy to identify genes that cooperate with the transgene in the formation and progression of tumours.In the host lab, the Tiam1 gene was identified by retroviral insertional mutagenesis in combination with selection for invasive T-lymphoma cells. The Tiam1 gene was also frequently activated (>70%) in T-lymphomas induced by retroviral infection of tumour-prone transgenic Em-Pim1 mice.Tiam1 thus seems to play a critical role in the initiation and progression of T-lymphomas. Tiam1 encodes an activator of the Rho-like GTPase Rac. Rho-GTPases regulate a wide variety of cellular processes including cytoskeletal rearrangements, cell migration, and gene transcription.Objectives: In this proposal we want to uncover the signalling pathways that act downstream or parallel of Tiam1and that are essential for lymphomagenesis in vivo. To this end, we propose to perform an insertional mutagenesis screen on tumour-prone transgenic EÂµ-Pim1 mice in a Tiam1-deficient background.Strategy: T-lymphomas will be induced in Tiam1-deficient EÂµ-Pim1 mice by Moloney Murine Leukemia virus (M-MuLV) infection. Targeted genes will be identified using improved Splinkerette PCR. The sequence data will be mapped and used to identify common insertion sites. The involvement of the gene targets in lymphomagenesis will be confirmed by in vitro and in vivo analyses.Results: The obtained results are expected to give insight into the downstream signalling pathways of Tiam that are acting in the development and progressi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Thermal Evaluation of specific drug delivery with Molecularly imprinted nanoParticles developed against Estrogen Receptor' (TEMPER) targeting Horizon 2020.

assistant: **Abstract**

Breast cancer is the most commonly occurring cancer in women with over two million new cases reported in 2018. It is a genetically diverse disease with each type requiring different treatment. In developing countries, the highest amount of female cancer deaths are attributed to breast cancer with substantially lower survival rates compared to the western world. Therefore, the aim of this proposal is to develop polymeric drug nanocarriers that can improve drug efficacy, and thereby have potential to make cancer treatment available to all layers of the population including those living in deprived areas.  We will develop high affinity nanoparticles that can selectively bind to certain receptors on the surface of cancer cells. When attached, the nanocarriers will release their cargo (drug compounds) specifically to the tumour and thereby improve drug efficacy and subsequently patient outcome. Furthermore, it will reduce adverse effects of common anti-cancer drugs including nausea, fatigue, hepatitis and high vulnerability to endometrial cancer. The drug delivery is usually monitored with optical techniques but the novelty of this project is to use thermal analysis, which is label-free and simple to use. The polymeric nanocarriers are highly versatile and by changing the composition, we can tailor this platform to other drug compounds or other cancer types. In addition, it has high potential as a diagnostic tool in high-throughput drug testing, customization of cellular therapy, and combating bacterial infections. This project could bring tremendous benefits in cancer treatment particularly in developing countries such as India due to its low-cost and simplicity.


**Keywords:** targeted drug delivery,  biomimetic sensors,  thermal analysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Biodiversity And Climate Change, A Risk Analysis'.

assistant: **Objectives**

1. The effect of climate change on forest biodiversity will be evaluated through better understanding of the ecological processes that shape species composition and are particularly sensitive to climate conditions. Forest species composition will correspond to the assemblage of tree species and both symbiotic and antagonistic species that can drive tree species composition. Climate conditions will include both average and extreme values of climatic variables (e.g. temperature, humidity and wind). 2. The relationships between forest biodiversity and functioning will be deciphered through better understanding of the respective role of tree species richness and composition and by focussing on the biotic interactions between species. As the fundamental ecological hypothesis behind the diversity – productivity relationship is the optimal use of resources, we will analyse the energy flow (i.e. resources production and consumption) across different trophic levels (trees and symbiotic organisms as producers, herbivores and pathogens as consumers). 3. In a final step we will aggregate the information from the first two steps to predict the effect of climate change on forest productivity through changes in tree species composition. The prediction will be expressed as a risk of dysfunction, in particular the risk of forest productivity loss. Traditionally, the risk for a given system is a function of hazard probability and system vulnerability to this hazard. In this case, hazards will be changes in average and extreme climatic conditions. Vulnerability will be the vulnerability to climate change of forest species that both shape forest composition and are the main drivers of forest biomass productivity. In each step, we will focus on fundamental ecological processes at work so th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'TOWARDS AN ENHANCED ACCIDENT MANAGEMENT OF THE HYDROGEN/CO COMBUSTION RISK' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Combustible gases are one of the few elements that can really challenge the containment integrity. An appropriate management of the associated risk is paramount to avoid the potential release of large amounts of radioactive material to the environment. Surprisingly, the Severe Accident Management Guidelines (SAMGs) have not been updated according to the knowledge gained in the last decade and the database extension resulting from recent and ongoing projects. The AMHYCO project intends to respond to practical questions, such as the right timing and mode for actuation of containment safety systems (i.e., FCVS, sprays, fan coolers) to reduce as much as feasible the threat posed to containment integrity. To do so, all the available tools to enhance the present status (i.e., LP, 3D and CFD codes, together with experimentation and the best use of engineering judgement) are to be applied. Three specific objectives are set:•            To improve the Severe Accident Management Guidelines (SAMGs) for both in-vessel and ex-vessel phases with respect to combustible gases risk management, using both numerical and experimental results.•       To investigate experimentally phenomena that are difficult to predict numerically: H2/CO/H2O distribution and combustion and PARs behavior under realistic accidental conditions, taking into account the safety systems interaction.•        To improve the predictability of the numerical tools - Lumped Parameter (LP), 3D containment and Computational Fluid Dynamic (CFD) codes - used for explosion hazard evaluation inside the reactor containment to gain relevance in supporting SAMGs design and development.The scope of this project is outlined by the most common reactor technology in the EU: PWRs. The whole project is structured in 7 WPs (coordinatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ACCURATE EASY-TO-USE AND NON-INVASIVE DEVICE FOR EARLY DETECTION AND MONITORING OF HEART FAILURE IN REAL TIME' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Heart Failure (HF) affects 15 million of Europeans and €6.41 billion are annually spent on its management and treatment by the healthcare system, CORALERT aims to favour the HF prevention and decrease its costs through its innovative NIRT MONITOR medical device. Gold standard procedures for diagnosing HF using catheterization are risky and complexes. As validated by clinical assay, NIRT MONITOR offers an alternative, safe and easy to use method to early diagnosis HF in real time by non-invasive measuring of LVEDP (Left Ventricular End Diastolic Pressure) providing physicians and in- and out-patient settings an early diagnosis of HF and its complications. NIRT MONITOR will improve the quality of life of patients while reducing hospitalizations by 30% and re-admissions by 80%. Cardiology, ICU, ER and Internal Medicine Units from hospitals (€5.1 billion of European market), GP offices and homecare settings will be the target users. NIRT MONITOR business model will be based on devices sales/leasing for early adopters and later from indirect sales/leasing through medical technology distributors. Revenues will be also generated by direct and indirect sales of disposables and by Cloud App payment fees. NIRT MONITOR will be an inexpensive solution (€10,000/device) in comparison with one catheter lab procedure (first two uses will save the 100% of the costs of one use of the standard method). NIRT MONITOR´s safety, easy to use, cost-efficient and accuracy will ensure its penetration into targeted European countries (Spain, France and Germany) and expansion over other European countries and US. We estimate a profit of ≈€38.5M after four years of commercialization with a ROI of 11.8 and a market share of 4.5%. We have filled US and PCT patent applications. To ensure the sucessful
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Coordination of Biological & Chemical IT Research Activities'.

assistant: **Concept**

COBRA is a coordination action to help organize the international CHEM-IT community towards the next major science and technology revolution, involving the integration of information processing with production during deployment. The industrial revolution mechanized production with factories, and the information revolution mechanized information processing with computers. The next large-scale technological revolution most likely involves their integration and its decentralization, as found so far only in living systems and it is now clear that significant scientific and technical progress towards this integration is imminent. The EC-sponsored CHEM-IT projects are spearheading the development and exploration of the first simple systems integrating production and information processing. This is done at the nano-bio-info interface, involving cellular engineering, protocells, artificial neurons and programmable information chemistry. At the centre of this work is a desire to create ICT-based systems with living and intelligent desirable properties that current technologies lack (such as robustness, autonomy, self-repair, adaptation, learning and local intelligence, as well as self-replication and evolution). The potential long-term impact of this emerging enabling technology will be considerable, as even minor progress on making technology more life-like and intelligent can improve processes in all sectors of society. CHEM-IT addresses issues of sustainability in production and deployment,  and the information explosion of ubiquitous nanoscale systems. The proposed project on the coordination of biological and chemical IT research activities (COBRA) seeks to engage the European research community to construct the first roadmap for how best to develop ICT-based integrated inf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Summer school recent advances in metrology and fundamental constants" (JULY 2000)"' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

In the frame of the International School of Physics Enrico Fermi", a course on "Recent advances in metrology and fundamental constants" is scheduled in Varenna, Italy, in July 2000. The aim of the school is to provide a broad basic formation to young researchers and to widen the knowledge and the culture of people having experience both in the field of metrology and of physical measurements. The presence of leading scientists of the different fields coming from all over the world will ensure a high scientific level of lectures, while the time scheduling of the school allows informal discussions to enhance the mutual interactions and to promote possible future international cooperation. The possibility of ensuring a large attendance of Young Scientists coming from EU and, in particular, from eastern countries is sought to give a valuable help to the metrological infrastructures currently under development."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Advanced material for cost-efficient and enhanced heat exchange performance for geothermal application' in the context of a Horizon 2020 call.

assistant: **Objectives**

Heat exchangers (HXs) are the most critical components of a geothermal power plant specially for organic Rankine cycle (ORC) based plant and the capital cost of heat exchanger accounts for a large proportion of ORC, and even reaches about 86% when air cooled condenser is used. Direct heat exchangers (e.g. geothermal brine to district heating) and ORC HXs such as superheater, preheater, evaporator are in direct contact with the geothermal brine, causing scaling and corrosion at different extent based on the thermophysical condition and chemical composition of the geofluid. To handle corrosion, expensive materials are recommended, but due to lower thermal conductivity and degraded performance over time compel to increases the size of the HXs. Hence, improvements in the antiscaling and anticorrosion properties as well as heat transfer performance of the HX material will lead to smaller, more efficient and less costly systems.GeoHex will rely on the use low cost carbon steel as base material for HX. Through modifying the surface with nano porous coating and controlling the surface chemistry (along with the surface structure), GeoHex will significantly improve the heat transfer performance of single phase and phase change heat transfer process respectively. To attribute the antiscaling and anticorrosion properties, the brine side of the surface will be Ni-P/Ni-P-PTFE duplex coated by electroless method.GeoHex will significantly reduce the cost of ORC plant while lowering the environmental impact. The technology concept can be exploited to build cost efficient HXs for solar thermal energy, heat pumps, absorption chiller, geothermal energy-based district heating cooling system. GeoHex enabled ORC plant, heat pumps and absorption chiller can be used for waste heat recovery appl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Engineering cancer dormancy as a collective emergent phenomenon: from matrix-enabled dormancy to collective dormancy-on-a-chip' (DORMATRIX).

assistant: **Innovation**

Cancer dormancy and the trigger to transition to active metastatic growth is a big open question. Current in vivo models focus on niche-specific cell and molecular mechanisms, ignoring biophysical aspects. Dormancy evolves with complex spatio-temporal dynamics; yet, there is a knowledge gap in the understanding of the heterogeneity of the units, and the dynamics of their interaction and evolution. Emergence occurs when a critical mass of units synergistically communicates giving rise to a new macro-level organization, with properties greater than the sum of the units. Engineering emergent phenomena in biological systems is a big research challenge as they originate from multiscale communication. In DORMATRIX, I propose a radically new view. I hypothesize that the balance between cancer dormancy and “awakening” is a collective emergent phenomenon, whereby a critical mass of micro-units communicates with each other and the environment in order to transition to metastatic growth. The main objective of DORMATRIX is to engineer breast cancer (BC) dormancy as a collective emergent phenomenon using biomaterials-based dormancy-on-a-chip devices. My previous data shows that we can (i) apply biophysical cues to control BC proliferation and (ii) visualize in vivo early BC bone metastasis. I will now address this outstanding challenge with a multidisciplinary approach and 1) apply biophysical principles with novel biomaterials to model in vitro cancer micro-units, 2) develop advanced 3D imaging to visualize collective cancer dormancy and bone microdamage, 3) develop in silico models based on evolutionary game theory to predict the dynamics, and 4) prove my hypothesis with dormancy-on-a-chip devices. Understanding the critical mass and multiscale communication required for emergent