RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Visualisation of translation initiation reaction on single mRNA molecules in vivo' (2014-2020).

assistant: **Concept**

Translation initiation is a key step in the regulation of protein synthesis and is regulated by at least 12 different initiation factors in eukaryotes (eIFs). However, the underlying dynamics of this process remain unclear. I propose to develop a single-molecule live-cell imaging method that can be broadly applied to study the dynamics of translation initiation on individual mRNAs in human cells. The aim of the project is to visualise the binding and release of eIFs and ribosomal subunits on single mRNA molecules in real-time during translation initiation. This method, combined with imaging the synthesis of a nascent polypeptide on a single mRNA, will address the role of dynamic eIFs assembly in heterogeneous mRNA translation events, such as translational bursting and start site selection. The project will uncover the real-time dynamics of translation initiation, reveal the key mechanism of translation regulation, and provide a powerful and generally applicable method to study translation initiation and other RNA-binding protein interactions with mRNAs. The project will be developed with a leading research group for translation imaging. I introduce single-molecule imaging techniques that would facilitate new research in the group and enable transfer of ideas. The project will expand my research experience, skills, and professional networks, thereby enhancing my career development as an independent researcher.


**Keywords:** mRNA translation, single-molecule
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Safe and accurate fetal monitoring' (2014-2020).

assistant: **Innovation**

Nemo Healthcare BV is a high-tech startup company – established after years of research - that focuses on the development of innovative technology for fetal monitoring. Fetal monitoring is essential to safeguard the health of mother and child during gestation and birth. The goal is to timely detect problems, such as preterm birth, oxygen deficiency (fetal hypoxia) or growth restriction, so proper action can be taken to mitigate the effects of these problems on both mother and child. Fetal monitoring consists of simultaneously monitoring uterine contractions and the fetal heart rate. Current methods are unsafe or not accurate (especially among overweight or obese patients (BMI>25; about 30% of the pregnant population).There is a clear market need for fetal monitoring technology that is accurate, safe (non-invasive), easy to use and applicable independent of the BMI level of pregnant women. Since overweight and obese women face higher risks of complications and their number is steadily increasing, the need for improved monitoring technology is becoming more urgent every day. Nemo is responding to this market need through the development of an innovative electrode patch and hardware/software module that can simultaneously record uterine activity and fetal heart rate – independent of BMI levels. The solution of Nemo is characterized by unique and smart algorithms that can accurately and real-time filter contractions and the fetal heart rate from unprocessed abdominal electrophysiological signals, successfully eliminating noise or interference. The solution will be able to transfer the recorded data wirelessly. The solution will create a breakthrough in the field of fetal monitoring: it will result in better diagnoses, improved quality of care, a reduced number of birth-rela
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Support for European Aeronautical SMEs' to be submitted under Seventh Framework.

assistant: **Abstract**

The AeroPortal project is created by the merger of the two support actions AeroSME and SCRATCH. It is the prime objective of AeroPortal to support aeronautical SMEs in advancing their technology base and their competitiveness through participation in European RTD projects. This is done by creating a single point of reference for information and project opportunities and by providing a wide ranging direct support encompassing:  - The support to help SMEs integrate both Level 1 and 2 proposals put forward by large companies; - The support to SMEs to set up their own project proposals.  AeroPortal will set up, and maintain, an internet portal, which will be an exchange place where project ideas, offers and requests of technical capabilities, partner searches, etc. can be posted and supported by an interactive database containing profiles of European SMEs and offering effective search features.  In addition to the “virtual” networking provided by the internet portal, AeroPortal will establish a permanent cooperation with all interested groups involved in support activities to aeronautical SMEs, such as SME clusters, National and Regional Associations, and also other funded Aeronautics Support Actions. These groups will be invited to become members of the AeroPortal Multiplier Group.  AeroPortal will cover all 30+ countries associated to FP7. Particular effort will be paid in continuing to stimulate the participation of Member States with aeronautical R&D potential.  The following measures will be implemented in AeroPortal:  - Establishment of the Multiplier Group open to all Aeronautics SME associations and groups; - Set up and maintenance of an internet portal for SMEs including an interactive and dynamic SME database; - Organisation of and participation in 20 national/reg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unlocking the antibiotic production potential in soil bacteria Streptomyces coelicolor' under Horizon 2020.

assistant: **Concept**

We live in an era where once miracle drugs – antibiotics, cease to be efficient. The rise of antibiotic resistance is an immediate major global issue. There are several layers causing the problem – misuse, overuse, lack of proper guidelines etc. The only long-term efficient solutions are – pushing more antibiotics and vaccines into the discovery pipeline. More than 70% of the naturally produced antibiotics used today come from non-pathogenic bacteria from the Streptomyces genus. These bountiful bacteria still have a lot to give, as only one-third of their secondary metabolite pathways are characterized. The rest of their potential stays locked away, i.e., inaccessible with the currently available approaches/tools. In STREPUNLOCKED project, we suggest a study of an up-and-coming pathway involved in the regulation of antibiotic production/resistance – adenosine diphosphate (ADP)-ribosylation. In order to achieve these aims, we will use a multidisciplinary approach that combines several latest mass spectrometry techniques and analyses, genetic approaches, molecular modelling and bioinformatics’ tools to characterize the novel ADP-ribosylation pathways, their signalling context, and their role in antibiotic production. Using the deep dive strategy in order to understand this pathway in Streptomyces would have multiple benefits: opening the doors to the new tool for manipulating the Streptomyces metabolism, lead the way to new lines of basic research, discovery and practical applications – such as new antibiotic compounds.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cell biology and lasers : towards new technologies' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Milestones:lasers and optical parametric generators;imaging technique for bio-objects;tunable time-resolved spectrophotometers;laser spectroscopy for environment monitoring, pollution detection and biomedicine;sampling; bioassays;minimal bio systems;cell response to treatment;principles of cell functioning.Expected results:technology for isolation of recombinant proteins, methods and instrumentation for bio-imaging and tumour visualization, forest and water monitoring, cellular optimisation of PDT, increase of knowledge and human potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'C9orf72-mediated neurodegeneration: mechanisms and therapeutics'.

assistant: **Innovation**

An expanded GGGGCC repeat in a non-coding region of the C9orf72 gene is the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The repeat RNA is transcribed and accumulates in neuronal RNA aggregates, implicating RNA toxicity as a key pathogenic mechanism. However, the pathways that lead to neurodegeneration are unknown. My lab has made pioneering contributions to the understanding of C9orf72 FTD/ALS, and reported the first structure of the repeat RNA, and the first description of both sense and antisense RNA aggregates in patient brain. We have now developed new disease models that allow, for the first time, the dissection of RNA toxicity both in vivo and in sophisticated neuronal culture models. We have also used our knowledge of the repeat structure to identify novel small molecules that show very strong binding to the repeats. We will utilise our innovative disease models in a multidisciplinary approach to fully dissect the cellular pathways underlying C9orf72 repeat RNA toxicity in vivo, on a genome-wide scale. Altered RNA metabolism has been implicated in a wide range of neurodegenerative diseases, indicating that our findings will provide profound new insight into fundamental mechanisms of neuronal maintenance and survival. This research programme will also deliver a step change in our understanding of C9orf72 FTD/ALS pathogenesis and provide essential insight for the identification of small molecules with genuine therapeutic potential. RNA-mediated mechanisms are now known to be a common theme in neurodegeneration, suggesting these findings will have broad significance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A pEdiatRic dosimetRy personalized platfORm based on computational anthropomorphic phantoms' (ERROR) under Horizon 2020.

assistant: **Objectives**

The main objective of ERROR is to develop a new software tool, which will offer to the clinician the possibility to assess alternative imaging and therapeutic protocols, in real time, in silico, in order to minimize patient dose, while maintaining image quality of therapeutic effect. This tool will be designed, implemented and evaluated with specific focus on pediatric patients, since this is a rather sensitive target group, where dose considerations are high and no standard protocols and solutions exist. The project will exploit the new generation of computational anthropomorphic phantoms, in combination with well validated Monte Carlo simulations and Machine Learning Tools. In this way, it is envisaged that advanced, yet mature technologies will be integrated, to provide a novel tool, which can lead to a final product.The ERROR project brings together a multidisciplinary consortium of specialists in different areas of medical physics, biomedical engineering, physicians and computer engineers, who will join forces in order to design, implement and clinically assess a novel software tools, which initial focus in the optimization of diagnostic and therapeutic protocols for pediatric exams. Two new SMEs will provide their expertise, as well as investigate the ways to exploit project outcome.A well planned exchange program among academic and industrial partners will facilitate knowledge sharing, maximize collaborative work and finally achievement of project objectives. The consortium, being aware of the scientific and social importance of pediatric clinical applications, has planned a series of dissemination and training activities, aiming at making project knowledge and outcomes available to the scientific community and society.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'DEMONSTRATION INSTALLATION OF A LEGIONELLA PREVENTIVE BACTERICIDE WATER FILTRATION FOR LARGE PUBLIC AND INDUSTRIAL FACILITIES' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The LEGIOTEX-DEMO project will primarily impact on the market for water-based equipment for indoors climate control and water distribution systems within large public and industrial facilities. Legiotex Demo is based on the results of the Legiotex proposal. The general objective of the project was the development of a water filter (LegioTex®WATER) capable to inhibit the growth and proliferation of the bacteria belonging to the Legionella Pneumophila family in water-based climate control equipment and sanitary water distribution systems in risk of becoming a source for legionnaire's disease outbreaks in large public and industrial facilities. For developing the aimed filter, environmental-friendly bactericides were appropriately fixed onto nonwoven textiles, assuring a long lasting biocide effect and optimum mechanical properties. The filter was mounted onto a disposal cartridge for its quick replacement, and this within a metal housing to be easily installed in different equipments, to have an optimum fluid-dynamic behaviour and successful commercialization. The aim of LEGIOTEX-DEMO is to install the product prototype for the prevention of Legionella contamination in a demonstration installation of a representative facility in risk of becoming a source of legionnaire´s disease (a potentially fatal pneumonia-like infection) to corroborate the efficacy of the developed prototype.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Hydrogen For Innovative Vehicles' under Seventh Framework.

assistant: **Concept**

HyFIVE is an ambitious European project including 15 partners who will deploy 185 fuel cell electric vehicles (FCEVs) from the five global automotive companies who are leading in their commercialisation (BMW, Daimler, Honda, Hyundai and Toyota).Refuelling stations configured in viable networks will be developed in three distinct clusters by deploying 6 new stations linked with 12 existing stations supplied by Air Products, Copenhagen Hydrogen Network, Linde, Danish Hydrogen Fuel, ITM Power and OMV.The project’s scale and pan-European breadth allow it to tackle all of the final technical and social issues which could prevent the commercial roll-out of hydrogen vehicle and refuelling infrastructure across Europe. Research tasks will ensure these issues are analysed and that the learning is available for the hydrogen community across Europe. Issues include:•Demonstrating that the vehicles meet and exceed the technical and environmental expectations for FCEVs•Establishing best practice on supporting FCEVs in the field, including new procedures for equipping maintenance facilities, training dealers, establishing a spare parts regime etc.•Using the stations in the project to understand progress on solutions to the outstanding technical issues facing HRS•Investigating the challenges of using electrolysers to generate renewable hydrogen•Understanding the impact of operating a network for filling stations operated by different suppliers, with different hydrogen supply modes•Understanding the buying characteristics of the earliest adopters, who will procure vehicles despite high costs and limited infrastructure•Providing evidence on the likely trajectory of the commercialisation of FCEVs in EuropeThe project will disseminate the results of this demonstration to opinion formers an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'STESS: Socio-Technical and multilevel perspectives on Energy Services Security'.

assistant: **Innovation**

Public and Government’s concerns about energy security have been increasing in recent years due to rising demand for energy, resources depletion as well as different types of  political, social, technological and environmental constraints on energy systems. The traditional approach for energy security is narrow and focuses on the security of supply. It concentrates on economics, international relations and technical aspects of the system.The proposed research, STESS, applies for the first time socio-technical and multi-level perspectives for studying energy security. It focuses on energy services and introduces an innovative research approach that aims to broaden the scope of energy security studies and to develop new criteria for the examination, analysis and evaluation of energy services security (ESS), and strategic responses to energy services threats. This done in the context of the transition to a low carbon economy and vis-a-vis traditional approaches to energy security.STESS will contribute to:(1) The theoretical development of the energy security literature which is currently dominated by energy supply and top-down approaches.(2) The development of ESS measurements and evaluation criteria, which are currently supply biased.(3) The development of resilience indicators and new strategic responses to ESS threats, which are currently supply oriented and involve a small set of actors.STESS is a comparative (Israel - UK) research and is composed of five stages:Stage 1 examines users practices, perspectives and perceptions of ESS;Stage 2 examines the institutional structure of energy service and ESS;Stage 3 examines roles that middle agents play in providing ESS;Stage 4 draws the governance structure of ESS, and develops multi-level criteria for the measurement and ev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The encoding of social networks in the brain' to be submitted under Horizon Europe.

assistant: **Abstract**

In social species, peers represent a major part of the external environment and adaptation to the environment requires adaptation to peers. One striking example is that not only other species can be deadly predators, but members from our own society can pose a deadly threat to us. On the other hand, not only family members can be our allies but also friends we choose from non-kin related group members. This matter of fact exemplifies the importance of tracking others and their relations, and possessing a structured knowledge about our societies. Primates, including humans and monkeys, spend most of their time watching others. While several neural circuits for social perception have been unraveled in their brains, we dont know how neural circuits further transform social percepts into a meaningful set of social concepts used spontaneously to represent social networks. This question calls for an investigation at multiple levels. An exploratory approach at the whole brain level, using functional magnetic resonance imaging (fMRI) in monkeys and humans, will enable us to chart the brain territories involved in processing social concepts of increasing levels of abstraction, whereby concepts about individuals are less abstract than concepts about relationships, which are in turn less abstract than concepts about social networks topology. Next, a nailed down approach to the level of neurons, using fMRI-guided neurophysiology, will enable us to understand the neuronal network mechanisms by which the transformation from multi-sensory social percepts to social concepts is implemented. Finally, exploiting real-world social knowledge of semi-free ranging monkeys, will enable us to track the encoding of social network topology by neuronal networks. Understanding how neural circuits a