RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Chromosomal addresses and mechanism of chromatin binding by the Scc2/Scc4 cohesin and condensin loading complex' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

In eukaryotic cells, cohesion between sister chromatids allows chromosomes to biorient on the metaphase plate and holds them together until they separate into daughter cells at anaphase onset. Accurate control of the mechanisms implicated in sister chromatids cohesion after DNA replication and chromosome condensation during mitosis are essential for faithful chromosome segregation during cell division. The aim of this project is to characterise the chromosomal features underlying Scc2/Scc4 binding to chromosomes and to understand the mechanism by which cohesin and condensin are loaded onto chromatin by the Scc2/Scc4 complex using as model organism Saccharomyces cerevisiae. The understanding of the mechanism of action of this complex is of particular interest since mutations in human Scc2 also result in sister chromatid cohesion defects, and are the cause of a severe developmental disorder, called Cornelia de Lange syndrome. The latter has been linked to Scc2 and cohesin’s role in transcriptional regulation, which the complexes also participate in. It is also worth to mention that chromosome segregation defects are commonly observed in cancer cells. Gaining insight into how the Scc2/Scc4 complex contributes to sister chromatid cohesion, chromosome condensation and even transcriptional regulation will advance our knowledge of fundamental aspects of chromosome biology and help in the understanding of human disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Optimizing Selectivity in C-H Functionalization Through Computational Design' (CHOPTOCOMP) targeting Seventh Framework.

assistant: **Abstract**

The activation of inert C-H bonds lies at the heart of organic chemistry. In particular C-H activation using transition metal catalysis has made a profound impact on complex molecule synthesis, but the area remains important for future discovery. At present the utility of synthetic methods based on C-H activation is hampered by the inherent difficulty of being able to selectively functionalize a single C-H bond in the presence of many others. Thus the ability to perform predictably site-selective C-H functionalizations on a given C-H bond in a complex substrate would be transformative for chemical synthesis.In this proposal we propose to perform computational studies on Pd-catalyzed C-H functionalization reactions, to uncover the inherent electronic bias of substrate structures on the site-selectivity. Calculations will be performed using density functional theory to characterize the mechanisms and catalytic cycle for Pd-catalyzed arylation of aromatic and heteroaromatic substrates. We will also develop quantitative models of reactivity and selectivity to deliver a greater understanding of the process, which will be used to generate predictions. The result will be a reliable predictive method with which to rationally design substrates and catalysts to deliver improved selectivities in C-H functionalizations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Protection by zinc and metallothionein against pathogenic mechanisms in atherogenesis' (1998-2002).

assistant: **Innovation**

The role of zinc and metallothionein in preventing vascular endothelial cell apoptosis induced by pro-atherogenic dietary factors will be studied at whole animal, cell culture and molecular levels. Studies will focus on the modulation of signalling mechanisms in human and transgenic mouse cells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Efficient Industrial Waste-To-Energy Utilisation through Fuel Preparation and Advanced Bfb Combustion'.

assistant: **Innovation**

To find a cost-effective method to recover energy from industrial refuse that is of less heterogeneous nature than MSW and that can be classified in such a way that its quality can be assured. In this manner the requirements for energy recovery will be less stringent than for MSW and for other unclassified waste streams. Still it is necessary to refine the technology for the combustion of these fractions such that consistent combustion quality can be upheld and that potential difficulties such as sintering, fouling and feeding problems etc, will not cause uncontrollable operational costs and production losses. The suitability of different industrial waste streams will be qualified as well as the volume of these streams in EU and a collection, handling and treatment strategy will be developed. A year round production of a storageable fuel will be developed and demonstrated in an integrated system with a district heat production plant which will have its major production in the cold win.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Performance Optimisation and Productivity 2' to be submitted under Horizon 2020.

assistant: **Abstract**

The growing complexity of parallel computers is leading to a situation where code owners and users are not aware of the detailed issues affecting the performance of their applications. The result is often an inefficient use of the infrastructures. Even in the cases where the need to get further performance and efficiency is perceived, the code developers may not have insight enough on its detailed causes so as to properly address the problem. This may lead to blind attempts to restructure codes in a way that might not be the most productive ones.POP2 extends and expands the activities successfully carried out by the POP Centre of Excellence since October 2015. The effort in the POP project resulted in more than 120 assessment services provided to customers in academia, research and industry helping them to better understand the behaviour and improve the performance of their applications. The external view, advice, and help provided by POP have been extremely useful for many of these customers to significantly improve the performance of their codes by factors of 20% in some cases but up to 2x or even 10x in others. The POP experience was also extremely valuable to identify issues in methodologies and tools that if improved will reduce the assessment cycle time.The objective of POP2 is to continue and improve the POP project operating a Centre of Excellence in Computing Applications in the area of Performance Optimisation and Productivity with a special focus on very large scale towards exascale.POP2 will continue the service oriented activity, giving code developers, users and infrastructure operators an impartial external view that will help them improve their codes. We will still target the same categories of users and focus on identifying performance issues and propos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Endometrial and embryonic genomics, searching for biomarkers in assisted reproduction (short title: Search for Assisted Reproduction Markers)' to be submitted under Seventh Framework.

assistant: **Abstract**

Infertility is a serious medical concern preventing the parenthood in 10% of couples. Infertility treatment using assisted reproduction techniques (ART) is popular in Europe with up to 5% of children born thanks to medical help. Despite many technological improvements the overall pregnancy rate after infertility treatment using the most commonly practiced in vitro fertilization (IVF) remains only 30% per single cycle. The specific features of human reproduction include the high prevalence of diverse chromosomal pathologies in oocytes and early embryos, and significant dysregulation in gene expression in embryo and endometrial tissue, both being the risk factors for implantation failure and decreased pregnancy rate after IVF. Hence, the intrinsic motivation for the current SARM project stems from the perceived need to contribute to future IVF improvements and benefit from the recent breakthroughs in technological innovations. Our primary research objective is to unravel the molecular nature of human preimplantation embryo development and endometrial maturation. This ambitious goal will be achieved by exploiting highly sophisticated single-cell genomics tools, such as fine-resolution mapping of DNA copy-number changes by using SNP-arrays and sequencing platforms, and characterizing single-cell transcriptional landscape by RNA-sequencing. These studies are likely to propose novel embryonal and endometrial biomarkers useful for selecting the most competent embryos for transfer or identifying the causes of female infertility of endometrial origin. The SARM consortium consists of 2 industrial (IVIOMICS, Paterna/Spain and Competence Centre on Reproductive Medicine, Tartu/Estonia) and 3 academic (Karolinska Institute, Stockholm/Sweden; Katholieke Universiteit Leuven, Belgium an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Medalus III: Project 1 core project' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The general objective is to undertake and consolidate fundamental research that can contribute to a deeper understanding of desertification processes. It is to apply the knowledge obtained to develop modelling tools as instruments for projecting the impact of different scenarios in specific target areas of the MEDALUS Project. Specifically the objectives are: a) to undertake a core programme of field measurements and process investigations at the field stations in Almeria (Spain), Spata (Greece) and Sardinia (Italy), in order to establish long term trends in desertification, investigate key processes of desertification and soil erosion and contribute towards establishing a European and international data and information base that can be applied to the management of semi-arid regions threatened by desertification. b) To develop, expand and consolidate the modelling activities associated with the MEDRUSH land degradation model and its application in the target areas. c) To complete the development of the MEDRUSH Model begun in MEDALUS II and to apply and develop this as a management tool in the Guadalentin, the Pescara and the Agri basins. The project consists of three modules: The first (The Core Field Studies Programme) will develop three field sites according to international standards, where basic data will be collected to develop indicators and monitor long term trends. Research will be done into processes of land degradation and recovery and at international sites. The basic field programme covers the collection of data needed to develop indicators for the long term monitoring of trends. This will be archived with the other project data and models and distributed on a CD-ROM. The research on land degradation and recovery includes studies of the role of soil fauna, s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on '5th ULLA Summer School for Postgraduate Training and Research'.

assistant: **Innovation**

The Fifth ULLA Summer School for Postgraduate Training and Research aims to implement a united research network amongst young academics of pharmacy throughout Europe. By bringing young researchers and proven experts together for training and development courses ULLA recognises that European research strengths and pharmaceutical industries alike will be furnished with capable and accomplished experts. The Summer School will adhere to the auspices of the European University Consortium for Pharmaceutical Research (ULLA). Comprised of the pharmaceutical departments of six European universities (in the case of London, the event host, the School of Pharmacy is an independent specialist institution of the federal University of London) ULLA provides considerable expertise in assessing the needs of the pharmaceutical sciences. In general, a united European Summer School specialising in the pharmaceutical sciences provides the opportunity to disseminate rapid advancements taking place in research techniques. It will also strengthen relations between academia and industry within the Community.Altogether, 120 young researchers will attend the Summer School: 90 participants will be active research/PhD students from the participating ULLA institutions, while 30 places will be reserved for both research/PhD students from other European universities and young researchers from industry. (NB. Young researchers from non-ULLA institutions and from industry will be self-funded.) Due to maximum participation levels of the scheduled course programme, the Summer School can accept no more than 120 participants. Up to 77 experts from both academia and industry will participate as instructors. Advanced publicity, in the form of a booklet detailing the aims of the ULLA Summer School and containing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The role of domestic markets and public policy for sustainable food systems: the case of Brazil' (DOMESTIC).

assistant: **Innovation**

Existing literature on agricultural markets, telecoupling, and supply chain governance focuses on global value chains, largely overlooking domestic markets  though these are responsible for the majority of food (74-88%), agricultural land use (78%), deforestation (61-71%), and global land use emissions (73%). A key barrier to the study of domestic markets is the lack of data. While country-level data are commonly used to track international trade, the data necessary to map subnational trade flows within domestic markets are seldom collated. In the proposed project we will bridge this knowledge gap by integrating novel datasets sourced from citizen science, wholesale markets, freight platforms, and government procurement contracts. Our focus will be on mapping the flow of food products within Brazil  the worlds ninth largest economy, a rapidly urbanizing, emerging market with a booming agricultural sector and large domestic market. We will employ life cycle assessment methods to these food flow data to compute the land use, deforestation, and carbon footprints of millions of individual supply chains and products. This will provide an unprecedented analysis of how the environmental impact of consumption varies across different populations and cities and how it relates to urban context. A key advance on previous product footprints will be our combination of supply chain data alongside information on land tenure, agricultural suitability, commodity prices, and forest fires to differentiate how much deforestation is driven by agriculture, rather than other contributing factors. Finally, the project will analyse public policies affecting food production and consumption, including a large-scale assessment of the Brazilian school meal program (PNAE) to understand its nutritiona
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dynamic Algorithms Against Strong Adversaries' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

From a procedural viewpoint, an algorithm is a list of instructions that transforms a given input into the desired output. While this paradigm has been successfully applied in theory and practice, it completely neglects the fact that in many scenarios the input is not given to the algorithm in its entirety at the beginning and might undergo changes that the algorithm needs to react to. Formally, such a situation can be modeled as a game between an adversary creating the sequence of updates to the input and an algorithm that tries to process each of these updates as fast as possible. Researchers have studied such dynamic problems with increasing interest in the past years.However, many state-of-the-art solutions suffer from at least one of the following drawbacks: (1) Many dynamic algorithms are randomized and assume that the sequence of updates is independent of the random choices made by the algorithm. This is not justified in situations where the next update to the input naturally depends on the previous outputs of the algorithm. (2) Many dynamic algorithms achieve amortized running time guarantees where the stated guarantee on processing each update only holds on average and occasionally significantly more time might be needed. This is insufficient for real-time systems requiring hard worst-case guarantees. The goal of this project is to design dynamic algorithms free from these two shortcomings. Formally, this amounts to giving the adversary the following additional powers: (1) adapting its update sequence to the outputs of the algorithm and (2) discarding the algorithm if some update is not processed in time. While isolated results in this direction exist, with some of them obtained by the PI, the unique feature of this project is the systematic study of these stro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sensor-Enabled Real-World Awareness for Management Information Systems' under Seventh Framework.

assistant: **Concept**

The objective of the SERAMIS project is to push the boundaries of current RFID implementations, thus turning them into powerful tools for intelligent information management. For this purpose, SERAMIS develops models, procedures, and tools for the handling of massive RFID data sets. The project aims at covering the entire causal chain from the initial investment in an RFID data collection infrastructure to the impact of data processing on firm performance and customer satisfaction. Not least, SERAMIS puts special emphasis on the analysis of privacy issues arising from RFID data. The project results are put into practice by two leading European fashion retailers and innovators in RFID usage. Our ultimate aim is to create benefits for individual business processes, strategic and industry-level impacts as well as guidelines for handling the trade-off between the interests of technology users and the privacy rights of their customers. The project outcomes are developed for the largest reuse possible and address the needs of players in the retail industry and beyond.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Elucidation of autophagy using novel chemical probes', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The interest on autophagy, an evolutionarily conserved process in eukaryotes, has enormously increased in the last years, since autophagy is involved in many diseases such as cancer and neurodegenerative disorders. Autophagosome formation is the key process in autophagy. Despite extensive work, the model of autophagosome formation is not yet well established. Some important questions on autophagosome biogenesis remain to be elusive, such as where the bona fide marker protein of autophagosome, LC3, is lipidated, how lipidated LC3 functions in autophagosome formation, and how the proteins for LC3 lipidation and delipidation are involved in autophagosome formation. Although genetic approaches have been useful to identify genes involved in autophagy, they are chronic and thereby the dynamics of phenotypic change cannot be followed, making them not suited for study highly dynamic process such as autophagosome formation. Herein, I propose to develop and use novel chemical probes to address these issues. First, I plan to prepare semi-synthetic caged LC3 proteins and apply them to monitor dynamics of autophagosome formation in the cell in order to address those questions on autophagosome formation. The semi-synthetic LC3 proteins are expected to confer a temporal control and to realize manipulation of protein structure, which renders such studies possible. Second, I intend to develop a versatile approach targeting specific endogenous proteins using a reversible chemically induced dimerization (CID) system, termed as “knock on and off” strategy. I plan to use this approach to elucidate the function of two distinct PI3K complexes in autophagosome formation. On one hand, the establishment of novel approaches will open up a new avenue for studying biological processes. On the other