RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of next generation pathways leading to just energy transition and industrial deep decarbonization' (PARADISE) targeting Horizon Europe.

assistant: **Abstract**

Foundation industries (cement, steel, glass, ammonia etc) are classified as hard-to-abate sectors due to the inherent high-temperature processes. Decarbonization of industry is technically possible through a combination of technical solutions, the optimum mix of which will vary widely between sectors and regions. Deep decarbonization technologies such as application of alternative carbon neutral fuels and carbon capture are essential to achieve the target of net zero by 2050 in the EU.The project aims to evaluate, develop and demonstrate the advanced and emerging technologies for sustainable energy transition and industrial deep decarbonization. Firstly, the project attempts to remove the barrier associated with high operational and infrastructure costs incurred by the traditional carbon capture and storage (CCS) technology applying aqueous scrubbing. The project also evaluates and justifies the potential of a negative CO2 emission solution by combining CCUS with biomass derived carbon neutral fuels (BECCS). In addition, the project aims to conduct a comprehensive feasibility study on the application of ammonia in selected industrial processes as an alternative carbon neutral fuel to replace fossil fuels. The project attempts to apply a wide range of research methods at different scales from microscopic material design to laboratory scale testing and pilot scale trials, and finally to industrial scale deployments supported by the industrial partners. Multi-scale modellings such as reaction kinetics modelling, CFD modelling and process modelling will be performed for system optimization. Techno-Economic Analysis and Life Cycle Assessment on carbon footprint of the full supply chain will be conducted for all three above-mentioned decarbonization pathways. Additionally, Ar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Biological Water Alarm System (BiWAS) for protection of urban drinking water infrastructure against CBRN threats' (BiWAS).

assistant: **Innovation**

Safe drinking water is essentially a global concern, thus resulting in a considerably large market for water quality monitoring. Besides, potential terrorists might threaten water infrastructure in European cities, since poisoning the tap water is a low-cost attack that easily generates social panic and economic loss to the society. Due to lack of the ideal early warning tools on water safety, large amount of routine sampling and testing have to be done frequently to fight against possible CBRN threats on urban water supply. This project addresses feasibility study for the technical and economic viability of Biological Water Alarm System (BiWAS): An innovative low-cost early warning device for monitoring of drinking water safety over a broad spectrum of harmful substances, including (1) acute toxicant chemicals, (2) chronic carcinogenic chemicals, and (3) waterborne pathogens. The innovative content of BiWAS lies in the miniaturisation and integration with multidisciplinary knowledge, which makes BiWAS a continuous, automatic and portable device working for long period with only annually or biannually maintenance. The potential customers include public water suppliers, household users, hospitals, hotels, culinary and food industries, etc. An early warning system against CBRN threats in drinking water can be realized without more investment. A feasibility assessment on BiWAS product under Phase 1 includes market investigation, business plan development, risk assessment, intellectual property management and innovation strategy development. In the potential Phase 2, a commercializable prototype of BiWAS will be expected, which can be probably the first low-cost and broad-spectrum early warning device for water safety. With the outcome of Phase 1, it will guide the European
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Role of facilitators proteins in the long range regulation of the human beta globin locus.' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Previously the focus of my research has been on the identification of regulatory elements in a relatively simple gene locus by DNaseI sensitivity and transgene assays. It is a natural progression from the identification of cis regulatory elements to the characterisation of factors that bind to them and to determine how such factors can bring about the remodelling of chromatin and activation of genes. The host laboratory is one of the leading research groups in the field and the expertise present will be invaluable in my training.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Sub-chromosomal regulation of mitotic transcription inhibition'.

assistant: **Concept**

Chromosome condensation during mitosis has long been assumed to render mitotic chromatin incompatible with transcription. However, recent evidence shows that some chromosomal regions (e.g. centromeres, some genes) are transcribed in mitosis. These findings imply that mitotic transcription inhibition (MTI) is not a global event along the entire chromosome. Instead, I propose that mitotic transcriptional silencing is spatially regulated, allowing specific loci to evade MTI and maintain their transcription.Testing this novel hypothesis is challenging due to our poor understanding of the mechanisms driving MTI. Additionally, commonly used techniques to study transcription (e.g. genome-wide approaches) provide snapshots of the process but lack temporal resolution to dissect fast changes in transcription. With SUB-SCRIPT, I will implement an advanced imaging tool in live cells to uncover the dynamics of ongoing transcription throughout mitosis, for selected loci. I will apply this approach to selected genes to test how transcription regulation in mitosis varies depending on gene architecture/identity. In parallel, I will make use of a putative MTI factor (my preliminary observations) to manipulate the transcriptional state of selected genes during mitosis. Both strategies will capitalize on my vast expertise in dCas9 use for chromosome targeting, which I will further exploit to imaging RNAs (dCas13). Ongoing work in the host lab on chromosome assembly and novel mechanisms that drive MTI provides an excellent environment for project implementation.The completion of this project will uncover how different genes display unique kinetics of transcriptional regulation during mitosis and how MTI is regulated at the sub-chromosomal level, challenging current views on how mitotic tran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Baltic Popular Science TV Show Futureshock""' under Sixth Framework.

assistant: **Concept**

Objective of the project The Baltic scientific TV broadcast Futureshock" is to help ordinary people to get a better sense of the achievements of science in their countries, Baltic region, Europe and to promote the role of science in the Baltic region, its opportunities in Europe and the world, and to promote integration of Baltic countries in the club of European science.The specific aim of this project is to produce and broadcast a cycle of programs, which focus on 18 important scientific events in the Baltic and the rest of Europe. Experienced partners of Science TV production companies from three Baltic countries will work together on the show. The program will be aired in prime-time (with re-broadcast) on the Latvian television (in Latvian and Russian), on the Lithuanian television (in Lithuanian) and on the Estonian television (in Estonian and Russian).Each programme: 26 minutes, weekly. Each producer will come up with own national version that will be supplemented with views from the other two countries with respect to the issue that is being discussed. On a basis of this cooperation 10 most interesting subjects HansaMedia would produce "International version" that would be available for adaptation by any Science TV program in the World. This aspect is especially essential as a first step ever, to promote Baltic perspective in global debate of International Science for wider public. Futureshock will be available not only in television, but also on the Internet.To define all 18 most important themes, to be covered by "Futureshock" the very beginning of the project will be to hold a conference of scientists appointed by Academies of Science of 3 Baltic countries, participants from the Baltic branches of the Association of Young Scientists and the Marie Curie Fellows
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sustainable Energy Transition in Shipping through Agreements, Industrial Leadership and Subsidies' (SET-SAILS).

assistant: **Concept**

The Sustainable Energy Transition in Shipping through Agreements, Industrial Leadership and Subsidies (SET-SAILS) project explores how competition and industrial policy can contribute to the market uptake of a future-proof alternative maritime fuel (AMF).To meet global and EU climate targets, the EU shipping industry is called upon to phase out conventional fossil fuels in favour of AMF, which encompass technologies with a different degree of market-readiness (liq.natural gas, biofuels, methanol, ammonia, etc.). So far, AMF account for a small fraction of total fuel demand and the high level of uncertainty on which AMF will become the next market standard undermines investments. Absent a comprehensive strategy for the AMF market uptake, the EU only prescribes a gradual reduction in carbon intensity of ships, while leaving the task of identifying the ‘winning’ AMF up to market forces. Hence, shipping companies and ports have an incentive in choosing less costly, short-term options, which diverts resources from AMFs that are more economically efficient and sustainable in the long term.By combining legal and economic research methodologies in the field of competition policy and transport policy, SET-SAILS provides the first extensive theoretical and qualitative analysis of AMF market dynamics and regulators’ practice within the EU. International workshops and a stakeholder survey will provide further evidence that will be translated into recommendations to policy-makers. A detailed map of the market ecosystem and regulatory framework will be drawn for each AMF type, while possible sustainability agreements between port and shipping operators will be assessed, as well as public-private funding to de-risk investments in AMF. SET-SAILS will be developed under the supervision
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'COMputational Models FOR patienT stratification in urologic cancers – Creating robust and trustworthy multimodal AI for health care', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

In the EU, treating patients with prostate (PCa) and kidney cancer (KC) costs more than €6.6 billion annually. Yet, PCa and KC are often managed inadequately, which is associated with high costs and negative consequences such as hospitalisation, psychosocial stress and poorer chances of survival. Diagnostic and therapeutic effectiveness depends on multimodal information, including cancer type, stage, and location as well as the patient’s age and health. Current clinical methods do not effectively use the large amount of mostly unstructured data. The main challenge in developing multimodal models is the lack of access to data sources and missing joint validation of data through collaboration between clinicians and computer scientists. A strength of our consortium is access to multiple sources of medical data, including the largest expert-annotated database for PCa and KC to date. Our overall goal is to develop and deploy marketable data-driven multimodal decision support systems to improve clinical prognosis, patient stratification and individual therapy for patients suffering from PCa or KC, defining a new state-of-the-art for the development of multimodal medical AI applications. We will develop AI models for PCa and KC that incorporate multimodal data, e.g., image data, unstructured medical text notes, laboratory information and biomarkers, and perform a prospective validation of the models in a large prospective multicentric international study. At the same time, we will assess the trust of healthcare professionals and patients in such AI tools and explore how this trust can be increased.By providing improved, personalised diagnosis and prognosis assessment, the multimodal models will ultimately contribute to better patient outcomes and quality of life. The models de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Exploiting an unusual polyketide chain release mechanism for production of novel enacyloxin antibiotic analogues'.

assistant: **Concept**

Enacyloxin IIa is a polyketide antibiotic with activity against Gram-positive and Gram-negative bacteria that targets ribosomal elongation factor Tu. It has recently been identified as metabolite of Burkholderia ambifaria AMMD and shown to have clinically-relevant activity against Acinetobacter baumannii, a problematic pan-resistant Gram-negative pathogen. Despite its promising biological activity, enacyloxin IIa has not been used in the clinic, presumably due to stability issues. Preliminary experiments have provided evidence for an unusual mechanism of modular polyketide synthase chain release in enacyloxin biosynthesis, involving intermolecular condensation of an acyl carrier protein (ACP)-bound thioester with the C-3 hydroxyl group of (1R, 3R, 4S)-3,4-dihydroxycyclohexane carboxylic acid (DHCCA). The resulting intermediate undergoes epimerisation at C-1 of the DHCCA moiety. This project aims to explore the ability of the chain release enzyme to catalyse the acetylation of a variety of DHCCA analogues with an acetyl-ACP analogue of the polyketide thioester intermediate. It also aims to identify the enzyme responsible for epimerising C-1 of the DHCCA moiety. DHCCA biosynthetic genes will be deleted in B. ambifaria and enacyloxin analogues, with a stable amide group in place of the labile ester group and other modifications to the DHCCA-derived moiety, will be produced via a mutasynthesis strategy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Medical Electricity, Embodied Experiences, and Knowledge Construction in Europe and the Atlantic World, c.1740-1840' in the context of a Horizon Europe call.

assistant: **Objectives**

Scientific knowledge has long been understood to be subjective and situated. ELBOW examines this situatedness from a previously unexplored historical viewpoint by investigating the role of lay embodied experiences in eighteenth-century scientific knowledge construction. The project starts from the premise that knowledge is necessarily filtered through individuals’ embodied cognition and therefore tactile, sensory, and experiential. Using eighteenth-century medical electricity as an empirical case study, the project analyses how patients’ embodied and experiential knowledge influenced the medical knowledge emerging from electrotherapies, as well as whose experiences and ways of knowing ended up contributing to scientific knowledge.  As a novel experimental therapy, medical electricity provides an exceptional window into practices of knowledge construction, authorisation, and marginalisation. Since electrical treatments and the bodily sensations they created were meticulously recorded by doctors and patients alike, these descriptions can be analysed as repositories of experiences and understandings of embodiment as well as epistemological beliefs regarding body, life, and matter. Medical electricity offers the perfect vantage point for examining popular epistemological understandings, their interaction with scientific epistemologies, and the way they manifested themselves in electrotherapeutic practices.  ELBOW devises an innovative methodological approach to tease out patients’ embodied experiences and epistemological beliefs from a variety of sources, including scientific treatises, doctors’ casebooks, advertisements, fiction, and ego-documents. Combining phenomenology and cognitive science with history of medicine methods, the project proposes a new, theoretically soph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dynamic Decisions in Maintenance' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The monitoring of machines and processes for predictive maintenance and control is crucial for sustainable and competitive industry in Europe. Distributed, autonomous monitoring is fundamental to the penetration of e-maintenance to the cutting edge of high capital and highly productive plant. DYNAMITE will create an infrastructure for mobile monitoring technology and create new devices, which will make major advances in capability for decision systems incorporating sensors and algorithms. The key features include wireless telemetry, intelligent local history in smart tags, and on-line instrumentation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Grey and green in Europe: elderly living in urban areas' under Horizon 2020.

assistant: **Concept**

The EU has to face many challenges in achieving a more balanced regional development and sustainable economic recovery. Many of those challenges have to do with the ageing population trend, urbanization and environment under distress. More liveable and efficient communities is a target to be reached in Europe, where the “silver hair” trends can become a challenging opportunity, from a social, economic and cultural perspective. Despite those challenges are strongly interlinked, solutions provided in urban contexts not often pay due attention to the social process underlying urban trends and to the needs and behaviour of elderly citizens. GRAGE intends to contribute to fill this gap, developing winning ideas to promote an active, harmonious and inclusive citizenship for elderly people living in urban contexts. The consortium gathers ground-breaking expertise from different scientific background (legal, economic, humanities, engineering), from academic and non academic institutions, belonging to several countries (from EU and Ukraine). Using a mix of methodologies, the research and innovation programme of the project will evolve around the idea of citizenship as a collector of interest, healthy environment and suitable urban solutions for an aging society. Main themes will be: green buildings, food and urban agriculture, information and language technology. Researcher will analyze their role in transforming cities in environments that support green and healthy lifestyles for elderly people. GRAGE intents to boost dialogue through Europe, both strengthening the academic and non-academic collaboration and a practical understanding of elderly living across Europe. Such a cooperation can have a series of returns for Europe, ranging from a more effective solution to strategic c