RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Investigations of structural changes in the f1-subunit of adenosyltriphosphate synthase in the presence of different nucleotides and nucleotide analogs'.

assistant: **Concept**

Research objectives and content ATP is the universal energy currency of life. All living cells need ATP to maintain themselves, to move and to reproduce. Understanding the molecular mechanism by which ATP is synthesised is a major goal of modern biochemistry. ATP is synthesised by ATP-synthase which is a large, lollipop-shaped molecule found in all cells. Although it is known that the soluble part, F1 ATPase, is powered by electrochernical gradients in the cell, the precise way in which this molecular machine is able to synthesise ATP is not known. The recently solved crystal structure of the native enzyme suggests that it may act like a turbine, with the rotation (and attendant ATP-synthesis) being driven by changes in the structure of the molecule itself. My goal is to extend the existing structure to higher resolution and determine the high resolution crystal structures of conformational states of the F1-ATPase that are relevant to catalysis. This will be archived by co-crystallising the nucleotide free enzyme with nucleotides, nucleotide analogs and inhibitors which arrest the enzyme in a particular conformation. To obtain highest resolution possible, the data will be collected at liquid nitrogen temperature at high energy synchrotron sources. Training content (objective, benefit and expected impact) The objective of this project is to become more familiar with the methods involved in determination and refinement of macromolecular crystal structures. The benefit would be to be able to conduct independent research after finishing this training period. Structural biology is a modern and greatly expanding field that has a great demand for qualified scientist familiar with the latest technology. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Early Literacy Teaching and Learning: innovative practice in four different national contexts, a thematic network' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The aims of this network are: 1) To contribute to the establishment in the EU to a 'shared knowledge base' on educational innovations in the area of early literacy teaching and learning. 2) To enlarge the perspectives of all players involved (researchers, teachers, teacher's educators, administrators) in terms of the potential of the early literacy. 3) To enhance the quality of early primary education in literacy, particularly for children from marginalised groups.Deliverables: 1) Observational and interpretative reports from a European perspective of four projects on early literacy teaching and learning in four Member States. 2) Video material on these projects. 3) A publication on issues arising from the four projects and from the thematic network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Environmental sensitivity of the Iberian peninsula to climate change' (2007-2013).

assistant: **Concept**

The continuing buildup of industrial greenhouse gases in the atmosphere and concomitant increase in global temperatures has made much of the world’s society aware that decades to centuries of environmental change lie ahead, and that these will have profound economic, political and societal impacts. In certain parts of the world the negative impacts of these changes will outweigh any possible positive effects. This is particularly the case for the Mediterranean countries, and large parts of the Iberian Peninsula. The effect that Global Warming will have on Continental Climates in Iberia and its correlation with Atlantic Merid¬ional Overturning Circulation (Atlantic MOC) is particularly critical because a reorganization of the Atlantic MOC will have profound effects on climates in the wider North Atlantic region and is the only known viable mechanism to cause substantial Abrupt Climate Changes that can occur on time scales < 30 years. The Iberian Peninsula lies in the boundary between tropical and subtropical climates and seems to amplify the climatic signals form the northern hemisphere through both atmospheric and water circulation feedbacks, making it an ideal site to monitor Northern hemisphere climate changes. This extreme sensitivity to climatic changes also makes the Iberian Peninsula extremely sensitive to future climate changes. This is why understanding sensitivity to climate change and the consequences it will have on both climate and the hydrological cycle is key to implement preventive measures. The aim of the project is to come up with a high resolution quantitative reconstruction of climate variability (temperature, production and precipitation) in the Iberian Peninsula from lake sediments to establish the relation between those changes and those observed i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Soft Matter Composites - An approach to nanoscale functional materials' to be submitted under Sixth Framework.

assistant: **Abstract**

The proposed network of excellence aims to establish a knowledge base for an intelligent design of functional andnanoscale soft matter composites. It will do so in overcoming the present 2 fold fragmentation of this extremely important field for the development of new materials at the interface of non-living and living matter where the delicate self-organizing principles of polymeric, amphiphilic and colloidal matter are ubiquitous. At present the field is fragmented along the disciplinary lines of theoretical and experimental physics, computer simulation, chemistry and applied biology. On the other hand we are witnessing another fragmentation following the material structures themselves in terms of polymers, colloids, surfactants, membranes and biopolymers. The overriding concern ofSoftComp is to overcome this 2-fold fragmentation in the creation of a virtual interdisciplinary research centre dealing jointly with the manifold of soft matter materials. This unleashes a range of exciting and intelligently designed hybrid materials and structures. The network unites the very best European research groups from the traditionally separated soft matter fields. It furthermore connects these academic groups with a sizeable fraction of Europe's most important industry dealing with such materials. All participants have already a track record in collaboration between disciplines ensuring the success of Soft Comp. By working on both materials and disciplinary axes of fragmentation, the leading researchers represented by Soft Comp will create an integrated team that is enabled to activate the European potential in soft matter composite materials and to disseminate excellence in extensive training and knowledge transfer schemes.'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Improvement of construction materials used in the food industry to lengthening processing time (MODSTEEL)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Fouling of processing equipment upon heating is one of the major problems in the dairy industry as deposit formation limits the desired heat transfer required for the microbiological safety of the product, reduces the flow and leads to pressure build up, whereas bacterial adhesion in the cooling section can lead to post-pasteurization microbial contamination. Cleaning at regular intervals is essential to overcome these problems. However, this requires interruption of processing, use of cleaning agents and large amounts of rinsing water, all attributing negatively to the cost of a process and leading to environmental problems. The aim of the project is to minimize fouling and to reduce cleaning by altering the surface properties of the heating surface, i.e. steel, to make it less attractive for the fouling components.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel mass spectrometry-based integrated analytical platforms for lipidomics studies on blood lipoproteins for cardiovascular disease research' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Cardiovascular disease (CDV) is a serious health issue and one of the main causes of death in developed countries. The connection between lipids and the disease progress has been established in the past years. Particularly, lipid composition in blood circulating lipoproteins may have a significant correlation with CVD and CVD risk. However, although in the past years lipidomics-based platforms have been developed and mainly focused on the lipid profiling in blood in diverse studies, little attention has been drawn so far to their study according to lipoprotein fractions, which is essential. In this project, the development of an integrated analytical platform will be tackled for the separation of lipoproteins from plasma samples, extraction of lipids in the protein fractions and lipid profiling. Lipoprotein separations by capillary electrophoresis will be coupled on-line to liquid-liquid extraction of lipids and further LC-MS/MS, to constitute the first integrated platform for this type of analysis. The implementation of the platform in a lab-on-a-chip system will be explored for achieving fast, automated, low sample requirement, high-throughput analyses. This will open-up a wide range of analytical possibilities and new insights in the lipid biochemistry in cardiovascular disease. The methodology will be applied for the analysis of plasma blood samples from healthy volunteers and individuals with different degrees of CVD for disease biomarker discovery. Finally, the analysis of samples from tracer-based studies in dynamic systems in mouse models will also be possible. In addition, this will allow studying the effect on drugs on lipid biochemistry, and to fine-tune exciting therapies or to develop new treatment options in CVD.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Individual and Collective Migration of the Immune Cellular System' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The immune system consists of a collection of cells with a high ability to migrate that work together to remove harmful foreign material from the body. Each immune cell can migrate between tissues, fulfilling specific functions in different microenvironments. However, this immune-surveillance response is not very effective in those tissues with a high non-physiological stiffness and a significant level of residual stresses, which are characteristics of solid tumors. Understanding the mechanisms that govern the cellular immune response to solid tumors is crucial to strengthen the development of novel immunotherapies. ICoMICS aims to develop a novel predictive modeling platform to investigate how therapeutic immune cells (TICs) sense, migrate and interact with cancerous cells and with the tumor microenvironment (TME). This platform will be built on two key pillars: in-vitro 3D tumor organoids and multicellular simulations, which will be combined and integrated by means of Bayesian optimization and machine learning techniques. On the one hand, cell culture microfluidic chips will be microfabricated, allowing continuous perfusion of chemical modulators through hydrogels (including decellularized matrices from murine stroma) inhabited by human tumor cells arranged to recreate 3D solid tumor organoids. On the other hand, an agent-based model will be developed to simulate cells as deformable objects, including cell-cell and cell-matrix interactions, combined with a continuum approach to model matrix mechanics and chemical reactions of cells, such as reactive oxygen species (ROS) and nutrients diffusion. Finally, ICoMICS will originally develop two innovative mechanistic-based immunotherapies. First, TICs will be subjected to high strains in micro-channels to induce them higher
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Developing Theatre: Building Expert Networks for Theatre in Emerging Countries after 1945'.

assistant: **Objectives**

This research project proposes a fundamental re-examination of the historiography of theatre in emerging countries after 1945 . It investigates the institutional factors that led to the emergence of professional theatre in the post-war period throughout the decolonizing world. The particular focus will be on the massive involvement of internationally coordinated ‘development’ and ‘modernization’ programs both East and West. The project will introduce the concepts of epistemic community, expert networks and techno-politics to theatre historical research as a means to historicize theatre within transnational and transcultural paradigms and examine its imbrication in globalization processes. This institutional and transnational approach will enable theatre studies to overcome its still strong national and local focus on plays and productions and connect it to current discourses on transnational history. The main objectives of this project are to:• examine how a global ‘epistemic community’ centred around theatre emerged in the post-war period; • investigate how ‘expert networks’ composed of government bodies, private foundations, transnational corporate philanthropy, local elites and individual artists sought to institutionalize particular forms and practices of professional theatre as an interconnected, transnational phenomenon; • develop a new interdisciplinary approach to theatre historiography by focusing on institutional structures, path dependencies and transnational imbrications rather than on works and authors.The principal investigator will bring to this project two decades of internationally recognized research into intercultural and global theatre. With its combination of institutional historiography and innovative research methods the project will provide a new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innovative Depalletiser for the automated feeding of signatures in the bookbinding industry.' in the context of a Horizon 2020 call.

assistant: **Objectives**

D-PAL is an innovative depalletiser based on grip technology used for the stacks of signatures handling and feeding the hardcover bookbinding machine in the printing, bookbinding and graphics atrs industry. D-PAL will increase the competiveness of the printing industry by improving the workflows and by saving approx. 3.6% of the printing cost directly related to labour cost for depalletising. D-PAL reduces problems related to the Health and Safety of the workers, is easy to operate and avoids the quality defects due to human error factor due to repetitive tasks. D-PAL is able to depalletise at a speed of 3600-7000 books per hour with high precision, flexibility and versatility. D-PAL is adapted to current methods of automated palletising with paper separators between the layers and is 20% less expensive than competitive solutions. D-PAL has been developed by LARGOIKO S.L.L, a Spanish Mechatronics Engineering enterprise that designs and carries out the automatization of industrial processes, special machines or under demand since 1999.European Union will be also impacted by D-PAL. D-PAL will be 100% manufactured in Europe (Spain) and it will attract foreign capital from USA.D-PAL will have impact in our company, LARGOIKO. We have invested more than €0.4M and we will invest €1.55M more in this project to put into the market D-PAL by January 2019. According to our forecast, we will have revenues of €9,100,000 by year 2023 from sales of our D-PAL depalletiser. The ROI of the project will be 2.60. During Phase 1 execution, we will develop a feasibility study including a business plan to assess the technological feasibility and economic viability. The general aim of D-PAL project is put into the market 8 units of our D-PAL by 2019.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Hardware & Software Development of Wireless Sensor Network Nodes for Measurement of Strain in Airborne Environment'.

assistant: **Innovation**

Today, wired sensors are used for monitoring aircraft engines, structures, gearboxes, etc. Wireless Sensor Network (WSN), i.e., smart sensors with radio interfaces, promise unprecedented operational benefits; such as, reduced airplane sensor wiring costs and weight as cabling is limited to specific scenarios and the flexibility to be deployed on-board aircraft without requiring a redesign of the data wiring layout.To this end, the StrainWISE project will develop an advanced wireless sensor platform to which a strain gauge can be connected, being able to operate in the wings of the aircraft for a long time, thanks to the use of embedded energy harvesters. The technical strategy is to build an integrated autonomous platform from existing, already proofed hardware and software, except for the energy harvesting part, which are specifically tailored to meet the objectives of the call.The resulting platform will clearly advance the state of the art in a number of aspects:• The WSN operations will always be tuned to their maximum efficiency resulting in lower energy needs, thus smaller form factor;• Efficient energy scavenging will permit further reductions in size and weight;•  Communication reliability will be improved by using all nodes as potential relays;• Management will be reduced to a minimum by automatic configuration and the use of standard protocols (SNMP)A number of specific tests will be performed in order to meet the requirements, limitations and constraints imposed by operation in airborne environments.The consortium is made of three highly qualified complementary entities. CSEM brings its expertise in WSN and ultra low power electronics. SERMA, an experienced actor in the aeronautics technology, will bring expertise in the aeronautics environment and constraint
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cryosphere-Carbon on Top of the Earth (CC-Top): Decreasing Uncertainties of Thawing Permafrost and Collapsing Methane Hydrates in the Arctic' in the context of a Horizon 2020 call.

assistant: **Objectives**

The enormous quantities of frozen carbon in the Arctic, held in shallow soils and sediments, act as “capacitors” of the global carbon system. Thawing permafrost (PF) and collapsing methane hydrates are top candidates to cause a net transfer of carbon from land/ocean to the atmosphere this century, yet uncertainties abound. Our program targets the East Siberian Arctic Ocean (ESAO), the World’s largest shelf sea, as it holds 80% of coastal PF, 80% of subsea PF and 75% of shallow hydrates. Our initial findings (e.g., Science, 2010; Nature, 2012; PNAS; 2013; Nature Geoscience, 2013, 2014) are challenging earlier notions by showing complexities in terrestrial PF-Carbon remobilization and extensive venting of methane from subsea PF/hydrates. The objective of the CC-Top Program is to transform descriptive and data-lean pictures into quantitative understanding of the CC system, to pin down the present and predict future releases from these “Sleeping Giants” of the global carbon system.The CC-Top program combines unique Arctic field capacities with powerful molecular-isotopic characterization of PF-carbon/methane to break through on:The “awakening” of terrestrial PF-C pools: CC-Top will employ great pan-arctic rivers as natural integrators and by probing the δ13C/Δ14C and molecular fingerprints, apportion release fluxes of different PF-C pools.The ESAO subsea cryosphere/methane: CC-Top will use recent spatially-extensive observations, deep sediment cores and gap-filling expeditions to (i) estimate distribution of subsea PF and hydrates; (ii) establish thermal state (thawing rate) of subsea PF-C; (iii) apportion sources of releasing methane btw subsea-PF, shallow hydrates vs seepage from the deep petroleum megapool using source-diagnostic triple-isotope fingerprinting.Arctic Ocea