RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'OLED-based bidirectional Neuroimplant' (OdiN) under Horizon Europe.

assistant: **Objectives**

Neurodegenerative diseases (NDs) affect millions worldwide and have complex causes, including genetic predisposition, environmental factors, drug use, and aging. Currently, there is no cure for most NDs, with treatments mostly aiming to alleviate symptoms and slow disease progression. In general, for any potential therapy, the preservation of neurons and their function—known as neuroprotection—should be a priority. The effectiveness of current therapies, including deep brain stimulation in case of Parkinson’s disease (PD), is limited due to their lack of spatial precision.The OdiN project aims to develop a flexible, implantable device that enables both neurostimulation and monitoring of neuronal activity. It leverages organic electronics technology, combining near-infrared (NIR) OLEDs to induce photobiomodulation (PBM) for neuroprotection and an OLED–organic photodiode system for detecting neuronal activity. This bidirectional device will be miniaturised to a few hundred micrometres and tested in vitro in a neuronal model of PD, where it will study the effects of PBM on neuroprotection. The device will also be implanted in a PD mouse model to assess its benefits for preventing neurodegeneration in vivo. A technical extension will explore scaling to multi-site stimulation arrays to achieve spatially controlled PBM.The OdiN project is positioned in the emerging fields of NIR OLED development and PBM, introducing a unique and unprecedented method for precisely targeting neurons without the need for genetic modification. This innovation not only simplifies experimental protocols in animal models but also opens the door to clinical applications that are far more accessible and ethically less problematic than current optogenetic techniques. It holds tremendous promise for adv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Heterogeneous Asymmetric Nanocluster-catalysis Design' under Horizon Europe.

assistant: **Concept**

Chirality plays a major role in several areas due to the different behavior of each enantiomeric form of a compound, critical in the pharmaceutical industry. Obtaining pure enantiomers is one of the most difficult challenges, in which homogeneous asymmetric catalysis has achieved significant steps. Now it is time to undertake the challenge by heterogeneous enantioselective catalysis, implying great advantages in terms of sustainability, and offers further opportunities for in-depth understanding of mechanisms at the molecular level, relevant in multidisciplinary fields. However, successful design of such processes requires understanding and control of all relevant steps, which requires well-defined catalysts designed at atomic level. A new class of atomically precise nanomaterials that offers ample opportunities to explore chirality at the fundamental level, are the monolayer protected metal nanoclusters, which exhibit unexpected catalytic and intrinsically chiral properties. The HAND project aims to tackle actual challenges in heterogeneous asymmetric catalysis and achieve enantioselectivity with chiral nanoclusters on surfaces designed at atomic level. After creating chiral clusters active in homogeneous asymmetric reactions, we will control their immobilization on the support surface and their chiral properties. Such atomically precise chiral surfaces will allow us to overcome sensitivity barriers of available chiral spectroscopic techniques, improving studies of chirality at surfaces. Finally, having a well-defined chiral surface, asymmetric/enantioselective model reactions will be explored, aiming to obtain pure enantiomers. Each process step by itself represents a novel pioneering work in the field of nanoclusters and asymmetric catalysis, so far mostly unexplored
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Bacterial warfare: Investigation into the Type VI secretion system-associated toxin repertoire and mechanism of target cell puncture in Pseudomonas aeruginosa'.

assistant: **Concept**

Pseudomonas aeruginosa is a human pathogen that causes life-threatening nosocomial infections. This organism has a range of virulence mechanisms, however its secretion systems play a key role in the transport of effectors, toxins and other virulence factors which are important for colonisation of niches including the human host. One newly identified secretion system is the Type VI secretion system (T6SS) which has been identified in a number of Gram-negative bacteria. This system is a specialised transmembrane complex which secretes toxins and other effectors into eukaryotic and prokaryotic cells. The H1-T6SS of P. aeruginosa is one of the best characterised systems and has been shown to target non-immune prokaryotic cells. To date, three toxins/immunity pairs (Tse1/Tsi1, Tse2/Tsi2 and Tse3/Tsi3) have been identified in P. aeruginosa. Importantly, in a P. aeruginosa triple toxin mutant, T6SS-dependent killing still occurs, suggesting more toxins are involved. The current research will identify novel T6SS toxins and elucidate their transport. The use of transposon directed insertion sequencing (TraDIS) will uncover the full P. aeruginosa toxin repertoire.The mechanism of T6SS target cell puncture and effector secretion is currently unclear. One possibility is that effectors are linked to the cell-puncturing device, VgrG. This hypothesis will be investigated by testing the ability of VgrG-toxin chimeras to mediate T6SS-dependent cell killing. To identify any non-toxin proteins that are secreted by VgrG, a Pseudomonas two-hybrid library will be screened, using full length VgrG or the C terminus of VgrG as bait. Finally, the puncture and delivery of effectors by the H1-T6SS will be examined using in situ live fluorescent microscopy.Overall, the proposed research will provid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Microbial activities of the sulfur cycle in the subsurface of the Iberian Pyritic Belt' to be submitted under Seventh Framework.

assistant: **Abstract**

Microbial processes in subsurface ecosystems are of increasing interest due to their implications for mankind, in regards to energy, climate and health. However, these ecosystems are among the least understood. The Iberian Pyritic Belt (IPB), located in southwestern Spain is one of the largest sulfide deposits on Earth. It is of tremendous interest due to its high concentrations of metals (As, Fe, Cu, Zn, Mn, Cr, Ni ..), and constant low pH (mean 2.3) in ground and surface waters. This has been largely attributed to mining practices over the last 5,000 years. However, recent evidence points to subsurface microbial processes contributing significantly to the oxidative processes that lead anomalous metal concentrations and low pH. Next to nothing is known about microorganisms and the processes they mediate in this system. The sulfur cycle occupies a central role in the biogeochemical pathways that occur in this ecosystem. Therefore, the goal of this project is to conduct a multidisciplinary study into the role microorganisms play in the cycling of sulfur, and implications of this on the local geology and groundwater geochemistry within the IPB. This project will innovatively combine tools that span engineering, geology, geochemistry and microbiology to achieve the following: (1) Identify regions where the oxidation of sulfides, both pyritic and non pyritic and the reduction of sulfate are occurring. (2) Determine the relationship between microbial community structure and underlying geochemical changes. (3) Determine microorganisms, mechanisms, and factors controlling pyrite oxidation, sulfide oxidation and sulfate reduction. (4) Develop a geomicrobial model for the sulfur cycle and it affects on local geology and groundwater geochemistry in the IPB. This project responds
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Synthesis, characterisation and theoretical analysis of spin-stabilised unsaturated mo - iii - alkyl complexes as potential polyerisation catalysts for functionalised substrates' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content The release of spin-pairing energy has long been established as a critical factor in the reactivity of transition-metal coordination compounds. Only recently has this concept been extended to open-shell organometallic species. The proposed research will apply spin-stabilisation to the generation of 15-valence-electron molybdenum(III) alkyl complexes under mild conditions. These unsaturated, spin-quartet species will possess an open coordination site cis to the alkyl ligand, a requirement for polymerisation catalysts. The electronic and steric properties of the molybdenum(III) alkyl complexes will be optimised by appropriate modification of the ancillary ligands. Advanced computational techniques will be applied to resolve spin-state an mechanistic questions as they arise. Mo-based polymerisation catalysts are expected to display a greater tolerance of function groups than early transition-metal metallocene catalysts, presenting the possibility of new materials derived from polymerisation (or co-polymerisation) of functionalised monomers. Training content (objective, benefit and expected impact) The proposed research will provide insight into the effect of spin state in stabilising open-shell organometallic complexes. The unsaturated alkyl species formed in this manner will be assessed as potential polymerisation catalysts for functionalised monomers. This project will enable me to: (a) further develop my skills in the synthesis and characterisation of new, paramagnetic transition-metal complexes, (b) acquire direct experience with advanced computational techniques, and (c) learn the methodologies associated with transition-metal-catalysed polymerisation. Joining the research group of Prof. Poli at U. Bourgogne will allow me to pursue thes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Polymerization and polymer modification in supercritical fluids - a novel way for cleaner manufacturing of plastics' in the context of a Fourth Framework call.

assistant: **Objectives**

Objectives and content Any polymerisation process employed for the production of plastics can generate large amounts of hazardous waste in the form of organic solvents, which may be hazardous on their own together with leftover monomer(s) and initiator(s). Even if the original solvent is plain water, the waste (contaminated water) is considered environmentally dangerous. The dissemination of chemical waste (volatile organic compounds, chlorofluorocarbons, and aqueous-waste streams) into our environment has prompted considerable world-wide concern, and environmental issues are now of paramount interest to the chemical industry. The present multi-disciplinary research programme aims at the design of new polymerisation processes for the manufacture and chemical modification of polymeric materials using supercriticalfluids (e g., CO2) as the dispersing medium. The transacted research will be directed towards the synthesis and characterization of novel polymeric stabilisers that enhance the solubilizing properties of carbon dioxide, which are crucial for its widespread application. Novel chemically- or gamma irradiationinitiated free-radical and ring-opening polymerisation processes will be developed for the production of polymeric materials (homo- and copolymers of PVDF, polycaprolactone) using supercritical CO2 as the dispersing medium. In order to improve the performance of existing polymeric materials, chemical modification of swollen particles of prefabricated polymers (e.g. polyolefins, polycondensates, styrene-maleic anhydride copolymers) in supercritical fluids will also be carried out. Specifically, the research efforts will be focused on the following scientific and industrial objectives:  Development of novel amphiphatic block, graft and starshaped copolymers. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'SN: The first blood biomarker to accurately STratify mortality Risk  In patients with Cardiac arrhyTmia' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Cardiovascular disease (CVD) is the no. 1 killer worldwide. 25% of all CVD mortality is caused by ventricular arrhythmias that lead to sudden cardiac death (SCD). The diagnosis of arrhythmias is difficult but crucial for accurate decision-making and patient survival. To assess the patient’s status, cardiologists currently ask: physical exams, some cardiac biomarkers data, an ECG (which may detect an arrythmia) and an echocardiogram to measure the blood ejection from the left ventricle (LVEF), since there is a correlation between LVEF and risk of ventricular arrhythmias. If LVEF is < 35%, the patient is eligible for implantable cardioverter-defibrillator (ICD) surgery, which costs at least 20K€. Still, around 51 % of victims of SCD have normal LVEF. In addition, 67% of all implemented ICDs are never activated because those patients were (unknowingly) at low-risk for arrhythmias, which represents a 1.3B€ overtreatment cost / year in the EU alone.CardiNor is bringing to market a new in vitro diagnostic (IVD) test to measure blood levels of Secretoneurin (SN), a globally patented biomarker and the only one shown to be specifically linked to ventricular arrhythmias. With SN data, cardiologists will be able to stratify patients according to their risk as well as to pinpoint high-risk patients not identified by the current diagnostic regime, thus reducing health burden costs and saving lives.CardiNor needs the SME Innovation Associate Programme to boost R&D activities within test maturation and effectively take it to TRL8. Currently, we do not have in-house expertise in biomedical device development or quality assurance. Therefore, we are looking to recruit an Innovation Associate. Acquiring these skills is important for CardiNor to maintain competitive advantage over coming y
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bringing innovative industrial biotechnology research to the market' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

IB2Market aims to bring industrial biotechnology from the research lab to the market and to solve the bottle-necks in industrialisation. Specifically, the project targets the development and scale-up of new industrial biotechnology processes that have recently been developed to produce the following compounds:1.Biosurfactants, tensioactive ingredients with a wide range of applications. Specifically, the project targets bola-sophorolipids, a completely new type of biosurfactants.2.Specialty carbohydrates, mainly for pharmaceutical and cosmetic applications. Specifically, the project targets L-fucose and fucosylated oligosaccharides that are very difficult to produce through extraction or chemical synthesis.For both product lines, the fermentation process and down-stream processing will be optimised and scaled up to 15.000 litre scale. Sufficient amounts of product will be produced for application testing and exploratory marketing, in order to identify the most interesting market segments.The technical, economic and environmental sustainability of the process from biomass to product application will also be assessed, with particular emphasis on identifying and solving the bottlenecks in the innovation chain. A valorisation plan will be drafted to complete the innovation chain. The project will result in the industrialisation and commercialisation of the developed products and processes.The project consortium has all the required players to move a process from lab scale to industrialisation: an open innovation pilot plant (Bio Base Europe Pilot Plant), a biotech start-up company (Inbiose), marketing companies for surfactants (EOC-surfactants) and specialty carbohydrates (Carbosynth), the RTD organisation that developed the processes at lab-scale (Ghent University), an appl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Image Analysis Online Services for in-vitro experiments' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Image analysis has become a powerful tool in multiple biomedical applications, ranging from clinical cases to cellular experiments. The main purpose of IMAGO is to extract relevant information from image-based analysis to perform comparative studies in 3D cell cultures. Most of the cell-based experiments have been performed in 2D, but 3D conditions are biologically more relevant. IMAGO presents the development of a tool for image analysis focused on, but not limited to, the quantification of cell behavior under different conditions. Indeed, IMAGO goes further by providing, when applicable, an image-based finite element analysis (FEA). There exist different professional software solutions, but either they don’t allow post-processing data analyses or they require specialized formation and/or experience to be used efficiently. Furthermore, to the best of our knowledge, none of them permits the extraction of mechanical clues by means of a linked FEA. IMAGO brings together all these features and offers them through an online service that allows the user to customize his own analysis. During the ERC project INSILICO-CELL, we have developed our own software to quantitatively analyze specific in-vitro tests involving particle transport, cell migration, angiogenic sprouting, actin flow, dendritic protrusions and traction force microscopy among others. But, this software is flexible and can be adapted and extended to a wide variety of in-vitro experiments. Thus, it is worth exploring market opportunities to offer our knowledge and expertise to other laboratories, so they can process images from in-vitro tests and analyze their results, either by using an existing function in our software or by developing a new one on request. Therefore, the expected outcome of IMAGO is to demonst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Activities Releated to Science', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The overall concept of our proposal is “Art of science” for both years respectively taking place on Friday 26 Septemper 2014 and Friday 25 September 2015 where we intend to generate an awareness and interest towards science by bringing scientists and all sections of the public close to each together in Istanbul, Turkey. Here, with this concept, we would like to enhance public recognition of researchers and their work, encourage active participation into scientific planning, experimentation and outcomes in one approache. Our approach is to assist the participants to be acquainted with how they “live, love, fun and learn” science in their daily life. For example, we will present them opportunities to the see how science affects our life, to experience the science in daily life by hands-on and minds-on activities, and to shape their view of science as a way of knowing. The participants will also have the opportunity to be introduced to the latest scientific developments in various fields by meeting and discussing with scientists. Vice versa, the researchers will find chance to make their work publically known. Furthermore, students at all levels will make meaning of their science courses, feel themselves closer to science and scientists, and eventually become more confident about science. Additional idea of the researchers’ night is to recognize the participants to be aware of the role of European Union framework programmes, the impact and effect they have had on the well-being of the public. This idea will be introduced by several activities involving participants and facilities demonstrated to the participants in EU corner.


**Keywords:** fun, live, learn, science, research, night