RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'THE IMPACT OF THE ENVIRONMENT AND ONCOGENESIS ON CANCER CELL DIVISIONS' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Mammalian cells must round up to divide by remodeling their adhesions and their cytoskeleton to form a stiff actin cortex. Mitotic rounding provides the space necessary to develop a mitotic spindle to undergo symmetric chromosomal segregation. If mitotic rounding is impeded by physical confinement or preventing adhesion remodeling, defects in spindle assembly and chromosomal missegregation can lead to mitotic cell death. In cancer, the cells must divide in a challenging environment which can alter the way cells divide. Preliminary data show Ras- activated epithelial cells are able to round better compared to normal cells. This adaptation could protect the dividing cell from the physical environment and allow epithelial cancer cells to divide in the confines of the tumor and distant metastatic sites. Here, we aim to identify mechanisms that allow epithelial cancer cells to divide differently from that of normal epithelial cells. Potentially, this mechanism could be a powerful target if we are able to prevent cancer cell division without interfering with normal cell division. Preliminary data suggest Ras-ERK signalling could play a role in mitotic rounding of cancer cells. In this proposal, I will 1) investigate ERK signalling dynamics during mitotic progression, how it regulates mitotic rounding and effects on the following cell cycle 2) investigate how Ras-ERK signalling and the mechanism of cell division are affected by environment using microfabricated tools and 3) initiate oncogenic activation by over-expressing receptor tyrosine kinases commonly found over-expressed in cancer or constitutive activation of Ras/Raf and measure changes in Ras-ERK signalling and cell mechanics. By establishing a link between Ras-ERK signalling and mitotic progression, I will determine h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Business scale up of an AI tool for the optimal design of power converters'.

assistant: **Innovation**

Industrial manufacturers of electronic devices face the problem of redesigning the power electronics for each new product that is going to be launched to the market. In this process, the bottleneck is the design of the magnetic components that are present in the power converters. The design of the magnetics takes around 6 months on average and the resulting designs are almost never satisfactory. Surprisingly, the same design methods have been used for the last decades. These methods generate delays and excessive costs during the manufacturing process and hold back the advancements in power electronics. SP Control is a company specialized in providing solutions for industrial companies to improve their processes. Our software FRENETIC, based on our proprietary AI technology, has attained great interest in the power converters market due to its capacity to achieve optimal designs for magnetics in just a few hours versus the current 6 months, meaning a design time reduction of nearly 100%. As a result, it allows to reduce the manufacturing costs and size by half. A minimum viable version of FRENETIC is being commercialised in a software design service model entering the power electronics market and bringing great benefits to our clients. Our objective is to disrupt the power electronics market with the first solution that will allow the industrial companies to obtain optimal designs for their magnetics in a matter of hours, reducing their manufacturing costs and their time-to-market. In order to take the fully evolved version of FRENETIC to the market, we need to scaleup our business model and demonstrate its value in a fully operative environment. In a market which value in 2023 has been estimated in €46 billion, the successful market uptake of our innovation represents a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ViSionRF: Vital Signal Monitoring using Radio-Frequency Technologies – Standard IF-RI' (ViSionRF), addressing dissemination and exploitation.

assistant: **Impact**

Dementia is a syndrome in which there is cognitive function deterioration and memory loss. Alzheimer's disease consists or contributes to 60–70% of dementia cases. At present, worldwide around 50 million people have dementia, but nearly 10 million new cases are added every year. The total number of people suffering from dementia is projected to reach 82 million in 2030 and 152 million by 2050 – a 3-fold increase. This puts tremendous pressure on the healthcare system and society as a whole. Equally important, dementia is overwhelming for patients' families and their carers, as they require full-time care and watch. For all these reasons it timely and imperative to develop a low-cost and efficient full-time health monitoring solution.The goal of this research is to develop an unobtrusive system Suite (ViSionRF) that will be able to capture the vital physiological signals of users (breathing, heart rate, heart beat shape, body position), remotely by using low-power radar, Wi-Fi and RFID signal technologies.  Envision a home with a single remote and unobtrusive device that acts as a stethoscope, heart monitor, irregular breath detector, and posture sensor. Such a home would have the ability to monitor your breathing, your heart (rate and pulse shape), and your position and alert your doctor when an emergency occurs. Such a home would help tremendously impaired citizens (e.g. dementia patients) and their carers.Unlike traditional patient monitoring systems that require users to ‘wear’ devices and sensors, the proposed system does not require wearing any wearable electronic or on-body sensor. This maximizes mobility and makes the system completely transparent to the user. This is important as dementia sufferers repeatedly forget or decline to ‘wear’ their sensors. The goal w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mems based Appliance for GYro Compassing in general aviation and unmanned aircraft applications' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In the future the demand for air traffic services will increase and will shift towards more unscheduled operations for air taxi, charter, fractional ownership, and on-demand small low-cost aircraft (A/C). Many players of the aviation community are planning to make significant investments in the specific Communication, Navigation and Surveillance (CNS) systems improvements over the next years, in order to enhance efficiency, safety, capacity and security.Inertial Systems, core component of CNS systems, are used to measure the attitude of an A/C with respect to local reference frame (heading, pitch, roll angles) and are composed by a set of inertial sensors called gyros and accelerometers. The existing commercial solutions perform aiding through non-inertial sensors, usually magnetometers, which can suffer from external interference that produce non-nominal performance in terms of accuracy. For pitch and roll angles self-initialization can be effectively realized by exploiting accelerometer measurement. Regarding the heading term, it can be estimated by sensing the local horizontal component of Earth Rate using gyros. This self-initialization technique is called “gyrocompassing” or “northfinding”, since the function of the compass is performed by gyros. Earth Rate is in the order of 15°/hour. As a consequence, very accurate gyros must be adopted. Recently, the development of miniaturized vibratory gyros, such as Micro Electro Mechanical Sensors (MEMS), allowed to attain a bias instability levels better than 1°/hour. However, this limit does not ensure that initial heading is determined with accuracy in the range 1°-0.1° (1σ). MAGYCO project aims at the development of an innovative aerospace grade Inertial Unit based on miniaturized vibratory gyros with autonomous northfin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Deciphering the building blocks of rocky planets using JWST spectra of planet forming disks' in the context of a Horizon Europe call.

assistant: **Objectives**

The James Webb Space Telescope (JWST) now peers for the first time into the rocky planet birth environments around Solar-type (T Tauri - TT) and Very Low Mass stars (VLMS) with ages of 1-4 Myr. The data shows that disk gas around TT stars is oxygen-rich, while it is carbon-rich around VLMS; yet they formed inside the same molecular cloud. VLMS are the most abundant stars in the galaxy, hosting most rocky exoplanets known to date, making them key targets to search for life. Yet today, it is paramount that we understand what causes this apparent difference, and the implications for the composition of forming planets and their evolution. JWST mid-infrared spectra contain a forest of molecular emissions which carries the complete information (gas and solids) about the planet forming environment in a complex way. The overarching aim of DISKS-ROCK is to thus characterize the current planet birth environments across stellar mass and to constrain disk evolution during the early build-up phase of rocky planets. I will draw from my expertise in thermo-chemical disk modeling, chemistry and mid-infrared spectroscopy to develop a novel, consistent and comprehensive 2D modeling framework to decipher the evolution that led to the apparent differences in gas composition between TT and VLMS. The key to fully exploit JWST data lies in quantifying how disk substructure formation, transport processes from the outer disk, and gas and dust chemical interaction shape the molecular emission spectra of the inner disks. DISKS-ROCK will characterize the current birth environment of planets and constrain disk evolution during the early build-up phase of rocky planets for a statistically relevant sample of ~50 disks. This will establish whether planets around VLMS and TT stars assemble from the sam
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Discover molecular pathways for marine glyco-Carbon sequestration' to be submitted under Horizon Europe.

assistant: **Abstract**

The scientific frontier project C-Quest will study algal sugar polymers - glycans - in the ocean to resolve their contribution to global carbon cycling and sequestration. C-Quest will explore the hypothesis that marine diatoms, which fix similar amounts of carbon as tropical forests on a global scale, secrete glycan types that are stable, meaning harder to degrade for bacteria than other substrates. This stability results in glyco-carbon sequestration removing the greenhouse gas carbon dioxide from the atmosphere. C-Quest will identify and quantify glycan structural types in seawater, where salt, low glycan concentration and their high molecular diversity challenge classic analytical techniques. With two articles in PNAS (2020) and Nature Communications (2021), implementing bioanalytical strategies to measure glycans in the ocean, we broke through the glyco-carbon challenge setting the stage for testing the glyco-carbon sequestration hypothesis. In the test tube, my team will reveal marine bacterial enzymatic degradation pathways that degrade diatom glycans. Our characterized enzymes will become analytical tools to identify and quantify these glycans across the ocean. In different oceanic regions, we will quantify glycan production during algal blooms, glycan export in sinking particles and glycan burial in sediments to pinpoint the types that have a high potential to sequester carbon. The outcome will be knowledge of glycan contribution to carbon sequestration shedding light into what remains a black box of the global carbon cycle to this day. C-Quest will discover enzymes new to science, explore the potential of glycans for carbon sequestration and reveal molecular principles that govern carbon sequestration in and beyond the ocean.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Exploiting pseudo-gauge fields for novel light-matter interfaces'.

assistant: **Innovation**

A central goal within quantum optics is to realize novel light-matter interfaces that enable efficient, controlled, and complex interactions between photons and atoms (or atom-like emitters) which is imperative for many emerging quantum applications. Current state-of-the-art paradigms include waveguide QED systems, where emitters are interfaced with structured photonic environments. Here one has exquisite control over the dimensionality, spatial structure and dispersion of the photonic guided modes, enabling new regimes of light-matter interactions with no analog in free space. However, in a quest for ultimate control, it is unfortunate that one cannot manipulate photons directly with electromagnetic gauge fields due to their lack of charge. This fundamental limitation has inspired various ways of engineering synthetic gauge fields for photons. Among these, one tantalizingly straightforward approach has emerged from graphene physics, where it has been shown that strain deformations of the membrane translate into pseudo-gauge fields in the effective Dirac Hamiltonian. ATOMAG is an interdisciplinary project that seeks to unveil pseudo-magnetic and pseudo-electric fields as fundamentally new elements in the quantum optics toolbox, enabling new regimes of light-matter interactions beyond conventional (periodic) waveguide QED systems. Combining this with the intrinsic nonlinearity of atoms, we will propose novel light-matter interfaces which could have important implications for the processing of quantum information, quantum communication and quantum simulation of many-body physics. Since pseudo-gauge fields can be generated by a simple, static variation of the system parameters, these novel light-matter interfaces should be imminently realizable.


**Keywords:** Photons, at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Complement-mediated phagocytosis in neutrophils' in the context of a Horizon 2020 call.

assistant: **Objectives**

Complement-mediated phagocytosis plays a crucial role in bacterial killing. Activation of complement yields a variety of opsonin molecules that can rapidly coat bacterial surfaces, which interact with complement receptors on neutrophils to facilitate phagocytosis. However the molecular details and functional outcomes of these interactions are not well understood. In the proposed work, we aim to elucidate the molecular details of complement opsonin-receptor interactions. We have developed a novel model for examining molecular complement interactions, by site-specifically attaching complement opsonins to bacteria-sized beads in their correct orientation. We will, for the first time, be able to adequately characterize complement opsonin-receptor interactions at a molecular level. This methodology will also be extended to two model gram-positive bacteria, Staphylococcus aureus (S. aureus) and Group B Streptococcus (GBS), in which complement opsonins will be site-specifically attached to their cell walls. Using wild-type and complement receptor (CR) knockdown neutrophils, we aim to determine the roles of opsonin-receptor pairs in neutrophil activation and bacterial killing. Finally, we will use our model systems to examine the synergy between antibodies and complement in neutrophil phagocytosis. The proposed work will provide a  comprehensive picture of the role of complement in neutrophil phagocytosis. As the role of complement in human disease is becoming increasingly apparent, the need for new therapeutics is imminent. The work proposed herein paves the way for several therapeutic applications, including targeted complement-dependent cytotoxicity (CDC) immunotherapeutics in cancer and complement inhibitors for a wide array of age-related, autoimmune, and rare/neglected di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Extractive membrane bioreactors for detoxification of chemical industry wastes' to be submitted under Fourth Framework.

assistant: **Abstract**

The project will:  -develop new and improved microorganisms for toxic organic degradation -develop improved pure elastomer and composite membranes for organic extraction from aqueous streams  -investigate the performance of membrane attached biofilms -test the EMB technology on site using real industrial waste streams.  The above activities will lead to an assessment of the technical and economic feasibility of the process being  made.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Single cell analysis of the lung tumour-immune ecosystem: Developing new tools for effective immunotherapy'.

assistant: **Innovation**

Tumours evolve to evade immune surveillance through a series of immune suppression mechanisms. In line with this, cancer immunotherapies, in which the immune system is turned on against tumours, are currently revolutionizing cancer treatment. Unfortunately, still many cancer patients do not respond to immunotherapies. Therefore, there is an urgent need to develop new tools for effective immunotherapy in order to increase treatment response rate. However, current methods that investigate bulk populations of cells lack the resolution to identify and analyse the diverse subpopulations of cells and the unique pathways and checkpoints they activate within the tumour ecosystem. I therefore aim to use advanced single cell genomic techniques for unbiased and high-resolution characterization of the different malignant, stromal and immune cell populations within the microenvironment of lung tumour, which is the biggest cancer killer in Europe. In combination with modelling approaches and advanced functional assays, I will identify subpopulations of cells specific to tumours, known and novel pathways mutated in tumour cells and cell-cell interactions that all together play crucial roles in the tumours pathogenicity. A comprehensive understanding of these processes provides the basis for understanding why existing cancer immunotherapies do not always succeed and provides new potential targets for the development of precise medicine tailored to individual patient.  Complementary to my skills in molecular and cellular biology, I will acquire scientific skills in single cell genomics and bioinformatics, and soft skills in project management, mentoring, communicating, etc in this project. Those skills will enable me to establish my own research group in the near future to investigate t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multi-modal platforms to drive vapour deposition of modular hybrid perovskite devices' (VAPOURISE) targeting Horizon Europe.

assistant: **Abstract**

Disruptive new technologies for generation, storage and use will be essential to drive the green energy transition and progress society. Such technologies must be developed with sustainable, high-throughput manufacturing, and maintain high-performance over long-term use. VAPOURISE will provide solutions by developing ground-breaking technologies for electricity generation (high-performance photovoltaics), storage (photoelectrochemical production of high-value chemicals) and use (quantum computing) based on scalable and modular perovskite semiconductors. These applications will be enabled by development of scalable vapour-based deposition methods to deposit epitaxial layers of 3D, 2D and 3D/2D halide perovskites, and low-temperature chalcogenide perovskites. Halide perovskite configurations will include multi-quantum-well stacks and functional spacer molecules imparting passivation of defects, optical activity and/or chirality. The development of these materials will be uniquely driven by fundamental understanding of properties through cutting-edge multi-modal operando toolkits and automated machine-learning driven analyses. These approaches will unveil unprecedented connections between the photophysical, chemical, structural and device performance/stability properties on different length (nanometre to centimetre) and time (femtosecond to months) scales, in turn guiding fabrication. This unique combination of controlled processing and fundamental understanding will allow VAPOURISE to generate highly stable, scalable, and efficient triple-junction photovoltaics (efficiency >35%), triple-junction photo-electrodes driving CO2 reduction to ethylene (>10%), and reliable electrically pumped single-photon emitter arrays. The ambitious, interdisciplinary programme will revolutio