RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Deciphering the roles of HDAC6 in the innate immune system', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Macrophages are key cellular components of innate immunity. During inflammation, they respond to danger signals by inducing gene expression or altering pre-existing proteins. One such post-translational modification is carried out by histone deacetylases, enzymes that remove acetyl groups from lysine. HDAC6 is a unique member of this family due to its cytoplasmic localisation and its structure (two catalytic domains and one zinc finger ubiquitin binding domain). Several targets of HDAC6 have been identified, including, recently, the mitochondrial protein mitofusin1, which induces mitochondrial fusion upon its deacetylation. Mitochondrial dynamics control several cellular functions, including inflammatory and antimicrobial pathways. My exciting project is based on strong preliminary data; there is no doubt that HDAC6 regulates mitochondrial dynamics and contributes to antibacterial functions, however the exact mechanism and the importance of each HDAC6 domain remains unclear. Thus, I will identify the exact role of HDAC6 and its three domains on the mitochondrial dynamics and the immune response in general. This project will also contribute to the characterization of new HDAC6-dependent pathways and HDAC6 substrates involved in the inflammatory response, delivering potential targets for future research. This proposal is based on an ideal synergy between the host laboratory (expertise in HDAC6 and proteomic analysis) and me (expertise in macrophage, mitochondria and microscopy). Thus, this project is highly feasible and combines: 1) an in-depth investigation of the role of HDAC6 on mitochondrial dynamics and immune response as well as 2) an analysis of HDAC6-dependent metabolites and 3) an unbiased acetylome screen. This project is perfectly in line with the Horizon 2020
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Breakthrough zero-emissions heat generation with hydrogen-metal systems'.

assistant: **Concept**

Disruptive energy generation technologies are urgently required to stave off catastrophic climate change. Now, more than ever, is the time to also to consider unconventional options. The subtopic c. Breakthrough zero-emissions energy generation for full decarbonisation of this call aims to answer this need. All of the research areas identified by the call are highly unconventional. As electrochemists, we will contribute to this call by working on hydrogen-metal systems. We propose to study hydrogen (and deuterium) evolution in unconventional conditions, i.e. on metal-hydrides and the main motivation for this work is based on the recent Nature perspective “Revisiting the cold case of cold fusion”. When loading deuterium into the Pd lattice, there is a chance that something very interesting will happen, resulting in production of excess heat. The first report of such reaction was published 30 years ago, but quickly dismissed by the scientific community. But what if there is really something? Can we afford to not to investigate this further, considering the current climate crisis? Google has recently funded a research project in this area, getting some interesting results but failing to produce excess heat. However, the team concluded that it was very difficult to achieve the required conditions reported for starting the excess heat production, and that “there remains much interesting science to be done in this underexplored parameter space.” This is a high risk/high reward project, but with aid of all the improved techniques and tools developed in the last 30 years, we believe that it is worth revisiting the topic. We will use state-of-the-art technologies to prepare, characterize and study electrochemical Pd-D system, both at room temperature and at temperatures up to 11
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Investigating Normative and Descriptive Uses of Confirmation Theory' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Inductive reasoning concerns how evidence affects the credibility of hypotheses, thus playing a crucial role in many cognitive processes (e.g. learning, diagnosis, prediction, etc.) and in several applied settings (e.g. law, medicine, etc.). It includes two related but distinct issues: (i) the assessment of degrees of belief in hypotheses in light of available evidence, and (ii) the assessment of the net impact of a piece of evidence on a hypothesis, i.e., the degree of confirmation provided by the former to the latter. Issue (i) has been subject of thorough investigation. Standard probability calculus is seen as the appropriate normative benchmark, especially by contemporary Bayesian theorists, on the basis of Dutch-book arguments. Also, inquiries in cognitive psychology have extensively tested the empirical validity of the normative account, identified its limitations and suggested various descriptive models to account for them. Issue (ii), however, has not attained comparable attention and consensus. A plurality of non-equivalent formal models of confirmation have been put forward, whose normative adequacy is still disputed. Confirmation has been experimentally investigated by cognitive psychologists in rather limited domains, and discussions of the connection between the normative and descriptive level have been sporadic. The present research project aims at filling this gap by pursuing the following goals in an integrated fashion: - extending preliminary theoretical and experimental results on both the normative and descriptive virtues and limitations of Bayesian models of confirmation; - providing a behavioral basis for the comparison of alternative models of confirmation in terms of a new analysis of the value of information; - exploring implications of confirmat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Root hair tip growth regulation by Arabidopsis RHD2 and ROP-GTPase genes'.

assistant: **Innovation**

Plant cells have two kinds of cell elongation systems; diffuse growth and tip growth. Tip growth is highly polarized and the growth only occurs at the tip of the cell. Root hairs are tip growing projections that arise from specialised root epidermal cells. The localization of growth to the hair tip is controlled by the local production of reactive oxygen species (ROS) produced by the RHD2 NADPH oxidase. Therefore identifying and characterising proteins that spatially regulate RHD2 activity is central to understand the mechanism of tip growth. However, how and where RHD2 protein is activated and regulates the accumulation of ROS at the root hair tip is still unknown. Thus, the aims of this research are to determine the subcellular localization of RHD2 proteins and determine if RHD2 is directly regulated by small Rho GTPases called ROPs, which I predict regulate this NADPH oxidase.   Firstly I will determine subcellular localization of RHD2 protein in root hair cells. I will use plants expressing an RHD2-YFP fusion protein in combination with confocal microscopy and spinning disc microscopy to investigate the protein localization during hair development.   Secondly, I will identify and characterize the ROPs that are expressed during root hair development. After identification of root hair specific ROP by whole mount in situ hybridization, I will determine the subcellular localization of ROP using plants expressing ROP and CFP fusion protein.   Thirdly, I will test if RHD2 physically interacts with ROP proteins. Because RHD2 is predicted to be a membrane protein, I will use split-ubiquitin yeast two-hybrid system to determine if RHD2 and ROP interact in vitro. For in vivo analysis, I will perform bimolecular fluorescence complementation (BiFC) and FRET approaches, both of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The livEs of Real woRld dAta (TERRA)' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Real-world data (RWD) refer to routinely collected data relating to patients health status and the delivery of health care originating from a range of sources other than traditional clinical trials. Electronic health records, patient registries or personal information collected from wearable devices are all examples of RWD. The Covid-19 pandemic saw the expansive use of RWD. Governments used these data to monitor populations health, while industry and drug regulators relied on RWD to assess the effectiveness of Covid-19 vaccines. Many of these RWD came from Israel and its data repositories. However, constructing the real-world through data is not a simple task. Producing data takes work from database curators, researchers or policy-makers, while it entails making decisions about what and who to include in the data to represent the real-world. In other words, producing RWD means representing, and enacting, versions of the real-world, while creating populations. Taking Israel as an empirical case study, TERRA aims to crack open the concept of RWD. Combining a literature review and an ethnographic study, TERRA has four objectives: 1) To map the emergence of the concept of RWD; 2) To develop an empirical analysis of the production, curation, uses and governance of RWD;3) To build a conceptual framework to understand and theorize the making of population and value through RWD; 4) To deliver a series of innovative dissemination events aimed at engaging the public and key stake-holders with RWD and its implications for practice. As lives are being datafied through RWD, we must critically investigate how such data are produced from individuals bodies. Specifically, when data are understood to capture the real-world, we must interrogate what and who is represented through these
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nano Optics for Molecules on Chips', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This project aims at the demonstration of detailed control of molecules realized by means of<br/>integrated electric, magnetic, radio frequency, micro wave and optical fields. The possibility of<br/>integrating all these components on a microchip and scaling down to the micro-meter scale and<br/>beyond will be combined with the ability of preparing and storing molecules in the electronic<br/>ground state in close proximity of the microchip surface or adsorbed on dielectric waveguides.<br/>Such a combination will offer unrivalled possibilities for the transfer of information between<br/>molecular (and/or atomic) states and optical or microwave fields or charged currents. The devices<br/>we will realise in this project will be a paradigm for future integrated machines able to control the<br/>external and internal degrees of freedom of individual molecules.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'LUMI AI Factory - Service Center', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

As AI technologies and methodologies continue to advance swiftly, Europe has been actively developing and strengthening the ecosystem of frameworks, environments, tools and services required to boost innovation. This comprehensive approach aims to harmonise AI strategies across the continent, addressing the technology’s challenges and opportunities, while assessing its impact on public and private sectors, and society at large. Leveraging the ongoing momentum and LUMI’s successful history, the Finland led consortium responds to the HORIZON-JU-EUROHPC-2025-AI-01-IBA call by introducing the LUMI AI Factory Service Center project, part of the broader LUMI AI Factory ecosystem leveraging the current LUMI supercomputer but gearing up for the upcoming LUMI-AI system and the related AI-optimised quantum experimental platform LUMI-IQ.


**Keywords:** Artificial intelligence, AI technologies, AI ecosystem, AI Factory, LUMI AI Factory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fair and inclusive twin transitions for a stronger social Europe' to be submitted under Horizon Europe.

assistant: **Abstract**

FITTER-EU (FITTER) aims to contribute to existing research on the origins, dynamics and determinants of inequalities and enable anticipatory governance to support a fair and inclusive twin transition in Europe. The project innovates by the formulation and development of an ecosystem (FITTER ecosystem) that pivotally includes a highly interactive and gamified Digital Platform powered by an Intelligent Predictive Decision Support System. Through a co-creation methodological approach, this ecosystem will enable policymakers to predict which social groups may be at risk of being adversely affected by twin transition policies under different scenarios, with the option to simulate the implementation of these policies to assess inequalities and social exclusion risks. The Digital Platform within the ecosystem will provide proposed mitigation measures and better practice guides that can be used to curve potential negative effects of policies on identified at-risk groups. The FITTER ecosystem also incorporates wider platform connectivity capability and better practice guides which, through a foresight engagement process, will help to meet the needs of the engaging FITTER Cluster Community Group of Stakeholders (CCGS). The CCGS includes key pan-European members such as policymakers, civil society organisations including trade unions, as well as business angels among other targets.


**Keywords:** Twin transition, intersectionality, risk assessment, co-creation, mitigation policies, gamification, digital platform
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Microscopy of Tunable Many-Body Quantum Systems' (MicroQuant) under Seventh Framework.

assistant: **Objectives**

We propose to take the experimental investigation of strongly-correlated quantum matter in the context of ultracold gases to the next scientific level by applying “quantum gas microscopy” to quantum many-body systems with tunable interactions. Tunability, as provided near Feshbach resonances, has recently proven to be a key ingredient for a broad variety of strongly-correlated quantum gas phases with strong repulsive or attractive interactions and for investigating quantum phase transitions beyond the Mott-Hubbard type. Quantum gas microscopy, as recently demonstrated in two pioneering experiments, will be combined with tunability as given by bosonic Cs atoms to give direct access to spatial correlation functions in the strongly interacting regimes of e.g. the Tonks gases, to open up the atom-by-atom investigation of transport properties, and to allow the detection of entanglement. It will provide local control at the quantum level in a many-body system for entropy engineering and defect manipulation. It will allow the generation of random potentials that add to a periodic lattice potential for the study of glass phases and localization phenomena. In a second step, we will add bosonic and fermionic potassium (39-K and 40-K) to the apparatus to greatly enhance the capabilities of the tunable quantum gas microscope, opening up microscopy to fermionic and, in a third step, to fermionic dipolar systems of KCs polar ground-state molecules. In the case of atomic 40-K fermions with tunable contact interactions, the central goal will be to investigate magnetic systems, in particular to create anti-ferromagnetic many-body states. The Cs sample, for which we routinely achieve ultralow temperatures and extremely pure Bose-Einstein condensates, would serve as a perfect coolant and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'In vivo analysis of the molecular mechanisms underlying glial cell differentiation' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content Despite the importance of gliogenesis in nervous system morphogenesis, the molecular mechanisms of glial differentiation have been poorly investigated. glide/gcm is a D. melanogaster gene expressed and required in glial cells. The project is aimed to determine the role of glide/gcm in gliogenesis and the genes regulating glide/gcm activity. To this purpose the effect of ubiquitous and cell type specific ectopic expression of glide/gcm will be tested. The definition In vivo of the minimal sequences necessary for glide/gcm activity will be obtained by rescue of the mutant phenotype via germ-line transformation. Finally I will perform a mutagenesis screen aimed to identify genes interacting genetically with glide/gcm by scoring for mutations that enhance or suppress the glide/gcm phenotype. Training content (objective, benefit and expected impact) The research project I propose will enable us to determine how glide/gcm induces gliogenesis and how its activity is regulated. To better understand the molecular bases of glial cell differentiation. The proposed project implies the use of different approaches in molecular biology and genetics. The possibility of carrying on the project in an institute of outstanding quality such as the IGBMC constitutes a unique opportunity to broaden my knowledge and skills in developmental biology and neurobiology and I consider that such training is fundamental for my research career.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Biological role of the atf2 transcription factor. Molecular mechanisms involved in atf2 regulated transcriptional activation' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content  Our research project will focus on two major points concerning the activity of the ATF2 transcription factor; 1) How does ATF2 activate transcription?, and 2) Biological role of ATF2. I) Previous work in Nic Jones' laboratory failed to detect any direct interaction between the activation domain of ATF2 and components of the basic transcription machinery. One of our major goals is to identify proteins that interact with the N-terminus of ATF2, preferably in a phosphorylation dependent manner. We will also assay if ATF2 can activate transcription by itself in an in vitro transcription system using chromatin templates. 2) To study the role of ATF2, three different dominant negative versions of the protein have been produced in Nic Jones' laboratory. Preliminary results from this lab suggest that these negative versions block T cell development. We will test why T cell development is blocked, by using retroviruses mediated gene transfer on fetal thymus organ culture. The same approach could be used to examine the involvement of ATF2 in the induction of apoptosis. Training content (objective, benefit and expected impact)  The use of dominant negative versions of ATF2 will prevent the expected redundancy between ATF2 and ATFa, and will avoid potential problems to study genes controlling particular biological programs in knockout mice (long-term procedures and possibility of embryonic lethality). Links with industry / industrial relevance (22)