RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Parametric fiber-based Mid-IR Swept-Source' to be submitted under Seventh Framework.

assistant: **Abstract**

The middle infrared (mid-IR) wavelength region between 2-5um is of great interest due to a wide variety of applications such as spectroscopy, or free-space communications and demand for high quality mid-IR lasers has significantly increased over the last decades. In conjunction, the ability to rapidly sweep wavelength has fueled many major developments such as real-time fiber sensor examination and chemical sensing.While significant research efforts are being funneled in the design of mid-IR sources, the need for compact and robust mid-IR wavelength swept source is ever present. The present proposal is aimed at fulfilling this need by designing a novel fiber based mid-IR wavelength swept source. A typical swept source is divided into two distinct components (gain medium and tunable filter) which hinders the tunablity and speed of the device. We thus propose to combine the two in a single element, eliminating these limitations. Combining gain and filtering is a concept supported by narrowband fiber optic parametric amplifier which has the definitive advantage that its gain spectrum is only limited by the transparency of the waveguide used. We therefore propose the use of heavy metal fluoride glass ZBLAN, with transparency up to 5um, inside a parametric oscillator pumped by a near-IR source. This constitutes a novel and promising approach which will combine mature near-IR devices with mid-IR materials in order to transfer near-IR performances to the region of interest. Mid-IR wavelength sweep will be directly controlled by the wavelength-swept near-IR pump for ease of use. A speed up inherent to four wave mixing will enable high sweeping speeds while maintaining high quality light generation. The proposal will thus explore phase matching in ZBLAN based narrow band paramet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Drug CandIdates ScreenINg', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Pluriomics is an international Dutch/Belgian biotech company specialised in developing stem cell-based assays for cardiac safety pharmacology and drug discovery and development. Pluriomics developed a unique proprietary protocol to differentiate heart muscle cells derived from human induced pluripotent stem cells (hiPSCs). The company provides its customers with reliable cell technology systems to test potential drugs in the preclinical phase with high predictive value. Safety issues remains a key problem in drug development. This is amongst others emphasised by the case of AstraZeneca where 82% of pre-clinical and 62% of phase I project closures where related to safety issues. Out of the safety related failures the cardiovascular system is involved in 17% of the preclinical failures and 24% of the clinical failures. Examples of cardiovascular effects, include arrhythmias, hypertrophy, hypertension and reduced ventricular function, which may lead to increased cardiac risk and possibly death. Additional reasons for the decline in success rates are related to the lack of predictive models for early drug efficacy screening. Pluriomics has developed Pluricyte® Cardiomyocytes and integrated proprietary assay systems to overcome the abovementioned challenges. Enabling market uptake and distribution of cell technology based innovations can be challenging, with large scale production and development of regulatory compliant predictive models as main challenges. DeCISIoN will tackle these challenges and thus accelerate market uptake of their cardiac safety assays. DeCISIoN will take the next steps and deliver 1) an up-scaled and more cost-effective manufacturing process; 2) novel, validated, predictive high-throughput cardiac assays for further improved cardiac toxicity and drug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tunneling spectroscopy on single molecular and semiconducting nanostructures' to be submitted under Fifth Framework.

assistant: **Abstract**

The development of nanosciences and nanotechnologies is based on the use of new tools to fabricate and manipulate materials at the nanometer scale, to achieve miniaturization through atomic and molecular manufacturing techniques. One major challenge is to be able to identify, to characterize, to manipulate and to get detailed information on nanoscale objects and devices. In this context, the electron transport through single molecules or semiconductor nanostructures receives an increasing interest from the researchers. Indeed, semiconductor nanostructures are often considered as artificial atoms or molecules, having in common with the molecules a discretization of their energy levels. The development of the Tunneling Spectroscopy on single nanostructures allows now to determine the electron levels with a high accuracy and, very recently, to image the corresponding waves functions. This field of science is emerging, with the main developments obtained within the last two or three years. There is a need to share knowledge, tools and techniques in order to improve the spectroscopy and to explore a broad range of new properties. Thus, the aim of the network is to build collaborative projects in the field of Tunneling spectroscopy on single molecular and semi conducting nanostructures". The nano-objects which will be studied in the project are semiconductor nanocrystals and quantum dots, and single molecules adsorbed on surfaces. Major breakthroughs are anticipated in several directions: knowledge of the electronic structure, inelastic tunneling, imaging of electron and hole wave functions using Scanning Tunneling Spectroscopy or Magneto- Tunneling Spectroscopy, probing spin polarization using Spin Polarized Tunneling Spectroscopy in magnetic field, and fabrication of nanode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Exploring the Dawn of the universe using Ab-Initio Simulations' (EDAIS).

assistant: **Innovation**

Inflation, the accelerated expansion of the early universe, is a leading mechanism for explaining the origins of perturbations in the primordial universe. During this epoch, tiny quantum fluctuations are imprinted in the primordial density field, serving as the initial conditions for the formation of all structures in the cosmos.To date, predictions from inflation have been limited to analytical techniques based on perturbation theory. The EDAIS proposal aims to revolutionise our understanding of primordial fluctuations and their role in structure formation by developing the first ab initio cosmological simulation. This simulation will begin deep within the inflationary era and extend to the present-day distribution of matter in the universe. This groundbreaking technology will surpass standard approximations, offering new insights into the properties of the large-scale structure predicted by inflation.Recent advances in lattice simulations of inflation have enabled predictions of non-Gaussian primordial fields, emerging from interactions during inflation. The initial phase of the EDAIS project will focus on significantly enhancing these simulations. Once the necessary resolution and accuracy are achieved, the resulting primordial density field will serve as the initial condition for state-of-the-art N-body simulations. This comprehensive approach will allow for the creation of physical maps of the present-day universe, which will be benchmarked against standard approximations to assess the strength of this novel methodology.The anticipated outcomes include an open-source ab initio code and ab initio maps of the universe for selected cosmological models, all publicly available for the research community. This technology is expected to establish a new standard in cosmolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Hypothalamic cell changes during menopause: the neuroendocrine origin of its metabolic alterations' under Horizon Europe.

assistant: **Concept**

Women health is heavily impacted by menopause, and specifically, metabolic alterations increase their prevalence compared to the pre-menopause stage. Among them, body weight increase associated with abdominal adiposity, augmented risk of metabolic syndrome accompanied with dyslipidemia, worsening of insulin resistance coupled to type 2 diabetes and reduced bone density which favors osteoporosis are commonly associated with this women’s period of life.The hypothalamus is a key brain area controlling several homeostatic systems such as energy balance, glucose homeostasis and bone metabolism. Ovarian hormones act on the hypothalamus to regulate female physiology but after menopause their production stops and both estradiol and progesterone are reduced to castrate levels. Previous data pointed that this lack of hormones affects hypothalamic function. However, whether menopause causes an alteration in the hypothalamic mechanisms controlling systemic metabolism and whether this potential impairment plays a role in the metabolic alterations associated with it, is currently unexplored.The global aim of HypoPause is to study the molecular and cell-specific changes occurring in the hypothalamus during menopause and understand their role in the pathophysiological mechanisms driving the metabolic alterations.To address this, a research plan will be implemented based on (i) multi-omics profiling and circuit plasticity assessment of the hypothalamus in preclinical models of menopause, ii) in vivo metabolic phenotyping and cell-specific manipulation of hypothalamic circuits in conditions mimicking menopause in rodents and iii) functional genome editing of molecular mechanisms in vivo and target-validation using human samples.HypoPause will provide the first molecular and cellular pict
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Design and implementation of data-parallel functional languages'.

assistant: **Objectives**

The framework of this project lies in the programming of high-performance computers. These computers are parallel or even massively-parallel machines, where tens, hundreds or thousands of processors work on the same computation simultaneously (in parallel). Unfortunately, current production languages for parallel machines are machine-dependent and difficult to use. Both these problems can be solved by moving to more abstract programming paradigms, like functional programming. The objectives of our project is to investigate compiler techniques for a class of abstract high-level, data-parallel functional languages.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A Preparatory phase proposal for the Square Kilometre Array' (PREPSKA) under Seventh Framework.

assistant: **Objectives**

The Square Kilometre Array (SKA) will be one of the largest scientific projects ever undertaken. It is a machine designed to answer some of the big questions of our time: what is Dark Energy? Was Einstein right about gravity? What is the nature of dark matter? Can we detect gravitational waves? When and how did the first stars and galaxies form? What was the origin of cosmic magnetism? How do Earth-like planets form? Is there life, intelligent or otherwise, elsewhere in the Universe?   There are several issues that need to be addressed before construction of the SKA can begin: 1. What is the design for the SKA?  2. Where will the SKA be located? 3. What is the legal framework and governance structure under which SKA will operate? 4. What is the most cost-effective mechanism for the procurement of the various components of the SKA?  5. How will the SKA be funded?  The purpose of this proposal is to address all of these points. We seek funding to integrate the R&D work from around the globe in order to develop the fully-costed design for Phase 1 of the SKA, and a deployment plan for the full instrument. With active collaboration between funding agencies and scientists, we will investigate all of the options for the policy-related questions. The principal deliverable will be an implementation plan that will form the basis of a funding proposal to governments to start the construction of the SKA.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Assembly of large synthetic genomes using nanofluidics'.

assistant: **Innovation**

Synthetic genomics is a rapidly growing branch of synthetic biology where the goal is to assemble a complete genome from small synthetic DNA fragments. The main obstacle is the later stages of assembly where fragments on the kilobasepair length scale are to be assembled, where the efficiency rapidly falls off with increasing fragment size. A large contribution to this bottleneck is purely physical, where the probability of DNA ends meeting decreases with increasing DNA size. My solution to this problem is to force DNA ends to meet using nanofluidic channels. In such channels DNA is stretched out to almost the complete contour length, exposing the ends for hybridization. As part of my ongoing ERC-CoG, I have demonstrated several principles that will make it possible to use nanofluidic devices for genome assembly. Long DNA can be entropically trapped in nanochannels to force DNA ends to meet to promote hybridization of complementary overhangs. The bacterial protein Ku stably anneals 4 bp complementary overhangs, making it possible to engineer which fragments that are annealed. Bacterial Ligase D then binds to Ku to ligate the DNA. Within this PoC project I will take the next steps to bring this principle to a commercially feasible platform.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Decarbonisation of carbon-intensive industries (Iron and Steel Industries) through Power to gas and Oxy-fuel combustion' (DISIPO).

assistant: **Innovation**

The project presents a novel concept that combines Power to Gas (PtG energy storage) and oxy-fuel combustion (carbon capture) to decarbonise carbon-intensive industries (iron/steel as case study). PtG consumes renewable electricity to produce H2 (stored energy) and O2 (byproduct). This O2 is fed in the oxy-fuel furnace in the iron industry to attain a high concentrated CO2 stream, thus avoiding the energy penalization of requiring an air separation unit. Besides, the stored H2 and the captured CO2 are combined via methanation to produce synthetic natural gas to be used in the industry or distributed through the gas network. The overall objective of the project is to reach TRL 2 in the novel PtG–Oxy-fuel–Iron/Steel concept through the following research objectives: 1) To design, simulate and optimize the integrated layout of the novel concept, 2) To assess the maximum CO2 abatement under a proper operational strategy adapted to the industry and the availability of the renewable energy resource, and 3) To compare the concept with iron/steel industries operating with conventional CCS, under economic and life-cycle analyses. The training covers 1) simulation of energy intensive industries, 2) market and industrial criteria and constrains for adopting new technologies, 3) life-cycle assessment and 4) horizontal skills through a wide-ranging programme of activities. These objectives will be reached through a mobility period in Waseda University supervised by Prof. Nakagaki (over 20 years of experience in the topic and 71 patents in collaboration with industry) and a secondment to K1-MET (Austrian Competence Centre for Advanced Metallurgy, driven by the Austrian steel industry). The project is relevant for MSCA due the extensive planned training aimed to gain skills and maturi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Primary Productivity Measurements in Freshwater: Converting Photosynthetic Electron Transfer Rates to Carbon Fixation Rates' (PROMON) targeting Seventh Framework.

assistant: **Abstract**

Acquisition of rapid, high resolution photosynthesis (i.e. carbon fixation) rates is a major challenge in aquatic research. One way to measure primary productivity in situ at an unprecedented temporal and spatial resolution is by active fluorometry (mainly Fast Repetition Rate techniques). Implementation of this technique, however, requires that the electron transfer rates (ETRs) measured by FRR fluorometry can be easily converted to carbon fixation rates via the electron requirement for carbon fixation (ER). Such conversions require detailed knowledge and a mechanistic understanding of the variation of the ER, which has been shown to exhibit considerable inter- and intraspecific variability. The objective of this study is, therefore, to assess the individual and combined effects of environmental condition and phytoplankton community composition on the ER. A combination of  state-of-the-art mesocosms with cultured phytoplankton and bioassays with natural phytoplankton communities subjected to different kinds of nutrient stress will be used to tease apart the individual and combined effects of environmental conditions (nutrient availability) and phytoplankton community composition on the ER. This knowledge will be critical for successful conversion of ETRs to carbon fixation-based primary productivity rates Only if generic relationships between the ER and environmental-taxonomic conditions can be established, can active fluorometry become a universally applied tool for primary productivity measurements in freshwater. The proposed project will lay the foundation for the widespread implementation of automated, routine primary productivity estimates and ecological assessments of freshwater habitats, as required by the European Water Framework Directive in an effort to resto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Organization of an international colloquium: moving targets: parasites, resistance and access to drugs" from 4 to 6 december 2000"' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

For more than 40 years the Institute of Tropical Medicine (Antwerp) has been organizing an annual colloquium on a topic of public health importance in developing countries. Its aim is to provide an up-to-date overview of the problem and possible solutions by bringing together leading experts, health professionals and scientists from north and south. This year the colloquium is jointly organized by the Institute of Tropical Medicine and Medicines sans Frontiers (MSF) and will focus on issues related to the treatment of major tropical diseases. More specifically the colloquium will focus on the ever- increasing problem of drug resistance in malaria and other diseases, the lack of safe and efficacious drugs for forgotten diseases such as trypanosomiasis and leishmaniasis and the limited access to existing or new drugs for many people in the developing world.