RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Overcoming chromatin restricted DNA access' (DNAccess) under Horizon 2020.

assistant: **Objectives**

Differential gene expression programs account for the diversity of cell types in our body. They are controlled by intricate networks of sequence-specific transcription factors (TFs) that operate in the context of chromatin. Chromatin is itself an essential component of this process, and is part of the system that selectively restricts DNA access for TFs. As a consequence, most TFs only bind to a small subset of their motif occurrences, in a way we currently do not fully understand. Our inability to predict binding of a TF based on its cognate motif and location in the genome is a serious obstacle towards predictive models of gene regulation.DNAccess has the ambitious goal to define in vivo the sensitivities of TFs to nucleosomes and their reliance on chromatin remodeling enzymes for binding. Using novel genomics and genome editing tools we will: (a) systematically vary TF motifs, presence of nucleosomes and their modifications at a defined chromosomal locus and quantify resulting TF binding; (b) explore genome-wide the ability of ectopic TFs to engage with a chromatinized genome in the absence of host cofactor engagement; (c) dissect chromatin remodeler dependent TF binding in order to define temporal order and subcomplex function and (d) deconstruct remodeler recruitment by mutating TF interaction domains. DNAccess will build a highly integrated setup to comprehensively characterize how nucleosomes, their modifications and mobility restricts genome access. We will characterize existing chromatin barriers and identify how TFs overcome them. This represents a crucial step towards a comprehensive understanding of the role of chromatin in gene regulation, and will advance our understanding of how specificity is generated in large eukaryotic genomes.


**Keywords:** Chromat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Craft Understanding, Education, Training, and Preservation for Posterity and Prosperity'.

assistant: **Innovation**

CRAEFT will deepen our understanding of making activities that include care, judgement, and dexterity standing on Anthropology, Knowledge Representation, Cognitive Science, Art History, Advanced Digitisation, Audiovisual & Haptic Immersivity, and Computational Intelligence to cover the multifaceted expression of crafts as living and developing heritage, as a sustainable source of income, and as the expression of the mind through imagery, technology, and sedimented knowledge. A generative approach will prove sufficiency for digital conservation, reenactable preservation, and scaling of approach for the full range of materials and techniques. CRAEFT will catalyse craft education and training with intuitive digital aids, telecommunications, craft-specific simulators, advanced immersivity, and high-end digitisation, to widen access, economise learning, increase exercisability, and relax remoteness constraints in craft learning. The integration of haptics intelligence haptics in digital design connects tacit knowledge in computer-aided craft-specific design tools. Workflow simulation will support experimental archaeology for the recovery of lost techniques. The analytic workflow analysis leads to digital fabrication opportunities for menial tasks, material savings and reuse, and reduction of energy consumption. Digital dimensions attached to individual works of craft will enable certification and attachment of digital content, but also enable reputation and community building, supported by a Community Portal for professionals and the public that connects to the New Media, hosts heterogeneous craft portforlios, and registers practitioner credentials.The efficacy of the approach will be piloted in eight representative craft instances with the cross-cutting objectives of Craft
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Modeling lymphoma pathogenesis in mice - from basic mechanisms to pre-clinical models'.

assistant: **Objectives**

Human B cell lymphomas including multiple myeloma and Hodgkin¿s disease are frequent malignancies and a major clinical problem. Their high incidence is due to special features of normal B cell development that promote chromosomal translocations and other genetic alterations. Another contributing factor is Epstein-Barr-Virus (EBV), a B cell-transforming virus endemic in humans. EBV-infected cells are usually eliminated by the immune system, but in immunosuppressed (post-transplant or AIDS) patients, EBV infection spreads and drives lymphomagenesis.We have generated a novel genetic tool that allows us to introduce combinations of loss- and gain-of-function mutations specifically into B cells in the mouse, to analyze the cooperation of oncogenic factors thought to contribute to B lymphomagenesis in humans. The unique feature of this method is that only a small fraction of cells is mutated (mimicking the sporadic nature of somatic cancerogenesis) and that cells having acquired either single or combined mutations can be observed side-by-side.Using a large set of mutant alleles, we will test whether the interplay of certain combinations of survival, proliferation and differentiation signals determines the development of different classes of human B cell malignancies. A special focus is on Hodgkin¿s disease, where EBV infection and genetic reprogramming play a critical role. We will also investigate the mechanism of immune surveillance of EBV-infected B cells and EBV-driven B cell lymphomas.Ultimately we hope to elucidate key pathways of lymphoma pathogenesis, identify novel contributing mutations, and generate preclinical mouse models to assess therapeutic strategies and mechanisms of tumor immune surveillance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Technology Transfer in Computing Systems'.

assistant: **Innovation**

The mission of the TETRACOM Coordination Action is to boost European academia-to-industry technology transfer (TT) in all domains of Computing Systems. While many other European and national initiatives focus on training of entrepreneurs and support for start-up companies, the key differentiator of TETRACOM is a novel instrument called Technology Transfer Project (TTP). TTPs help to lower the barrier for researchers to make the first steps towards commercialisation of their research results. TTPs are designed to provide incentives for TT at small to medium scale via partial funding of dedicated, well-defined, and short term academia-industry collaborations that bring concrete R&D results into industrial use. This will be implemented via competitive Expressions-of-Interest (EoI) calls for TTPs, whose coordination, prioritization, evaluation, and management are the major actions of TETRACOM. It is expected to fund up to 50 TTPs. The TTP activities will be complemented by Technology Transfer Infrastructures (TTIs) that provide training, service, and dissemination actions. These are designed to encourage a larger fraction of the R&D community to engage in TTPs, possibly even for the first time. Altogether, TETRACOM is conceived as the major pilot project of its kind in the area of Computing Systems, acting as a TT catalyst for the mutual benefit of academia and industry. The project´s primary success metrics are the number and value of coordinated TTPs as well as the amount of newly introduced European TT actors. It is expected to acquire around more than 20 new contractors over the project duration. TETRACOM complements and actually precedes the use of existing financial instruments such as venture capital or business angels based funding.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Generating superior industrial yeasts through modulation of Crabtree repression' (SUPERYEAST).

assistant: **Concept**

The common baker's yeast, Saccharomyces cerevisiae, is used in various industrial applications, ranging from the production of fermented beverages like beer and wine, foods including bread and chocolate, bioethanol, enzymes and pharmaceuticals. S. cerevisiae cells can grow aerobically, using the TCA cycle and electron transport chain to produce around 16 to 18 molecules of ATP (energy) per glucose molecule. However, when glucose concentrations exceed about 1% (w/w), the cells tend to shut down this respiratory mechanism in favour of alcoholic fermentation, even if this metabolic route only yields 2 ATP molecules per glucose consumed. This so-called ""Crabtree effect"" makes it difficult to efficiently cultivate industrial yeasts in large-scale industrial fermenters because maximal biomass yield is only obtained in conditions where glucose concentrations are kept below the critical limit for activation of the Crabtree effect, but high enough to allow maximal growth. Interestingly, however, some S. cerevisiae strains seem to be less sensitive to glucose inhibition of respiration than others, suggesting that certain natural strains harbour specific alleles that make them less subjected to Crabtree repression. In our ongoing ERC CoG, we have shown that besides limiting efficient biomass formation, the Crabtree effect also decreases the efficiency with which strains can metabolize industrial media. Moreover, we identified an as yet uncharacterised gene, YLR108C, that controls the glucose level at which respiration becomes repressed. Our preliminary results show that swapping natural alleles of YLR108C changes the level of glucose at which the Crabtree repression starts. In this PoC, we propose to use our findings to generate superior industrial yeasts that combine optimal in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Deposition of wear resistant coatings by magnetron sputtering combined with plasma immersion ion implantation' under Fourth Framework.

assistant: **Concept**

The objective of the project will be to study the effect of PIII based coatings on the mechanical performances of austenitic stainless steels, which have excellent corrosion resistance but poor wear behaviour. In Plasma Immersion Ion Implantation (P. energetic ions, drawn from a plasma by high voltage pulses onto the workpiece to be modified, lead to structural compostional modifications of the surface and the surface-near region and induce changes of the surface properties and behaviour. The particular feature of this technique is its lower process temperature compared to other plasma techniques. At the University of Augsburg in Germany, PIII group created a new version of PIII-technique combining it with Magnetron Sputter Coating, up to now the only one of this kind in the world. In this project different steels will be coated with titanium based hard materials (TiN, TiCN, TiAIN) by using various types of in vacuo pretreatment (ion etching at low ion energy and plasma immersion ion implantation of nitrogen at high ion energy), coating (by magnetron sputtering optimizing the different process parameters) and post treatment (PIII of the deposited coatings modifying their composition and/or structure). The coatings will be then characterised by different analytical techniques (AES RBS, XRD, STM, AFM) and mechanical tests to measure hardness, adhesion and wear behaviour (nanohardness, pin-pull test, scratch test, pin on disc). The corrosion resistance will also be tested by exposing the coated steel to various corrosive media. The joint research project between the partners* will also address the industrial applicability of PIII/Sputtering technique for fabricating hard material coatings. In Europe research activities on this topics are carried out in England and in Germa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A digital guardian angel enhancing cancer patient’s wellbeing and health status improvement following treatment.'.

assistant: **Concept**

The burden of cancer is rising globally and is estimated to have reached 18.1 million new cases and 9.6 million cancer deaths  in 2018. Despite the rising cancer incidence, improvements in early detection and therapeutic treatment have improved cancer survival. As a consequence, the number of cancer survivors is increasing globally, creating the need to improve not only treatment but also wellness and follow‐up care. Cancer treatment often involves combined modalities  such as surgery, chemotherapy, and radiotherapy. In the past decades, more effective and targeted therapeutic modalities and less destructive cancer treatments have been developed  such as immunotherapy and drug‐targeted therapy.  Even so, cancer and its treatment have important physical and psychosocial sequelae. ONCORELIEF is a 36-month action that will leverage the above 6 drivers in order to skillfully and methodologically overcome technical challenges, by introducing new approaches that will allow the utilization of big datasets in order to develop a user-centered AI System to facilitate the integration of QoL assessment instruments through the use of PROMs and PREMs in order to improve post-treatment health status, increase the wellbeing, and follow‐up care of cancer patients. This will be achieved through an intuitive smart digital assistant (Guardian Angel), able to provide personalized support in post-treatment activities and tasks, suggest actions regarding the patients' overall health-status, improved wellbeing  and active health-care and ultimately maintain him/her engaged on a wellness journey that will safeguard his/her health over the foreseeable prolonged post-cancer treatment period. To achieve this, ONCORELIEF builds on the combined knowhow of its interdisciplinary industry-driven consor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Renewable electricity and liberalised markets'.

assistant: **Concept**

The objective of the project is to determine the role of renewable energy in the strategies of electricity utilities across Europe in the context of the liberalisation of the European electricity sector. The specific objectives of the study are to: - examine the influence of liberalisation on the way electricity utilities will incorporate renewable energy into their business plans in liberalised markets; - determine whether the impact of market liberalisation will have a positive or negative effect on the uptake of renewables by utilities, and whether the lessons learned can be replicated to other utilities elsewhere in Europe; - determine where liberalisation might appear to impede or disadvantage the uptake of renewables by utilities, define the measures that would need to be taken to counter any negative effects, and thereby further EU policy towards renewable energy; - assess the role of renewables as a component in the energy supply strategies of the utilities; - define how the commercial marketing strategies of the utilities are, and will be affected, by adopting renewables as part of their energy mix; and, - additionally, provide insights into how these utilities are adapting their market strategies in light of EC directives and within the context of the changing electricity markets. The project will provide specific and important information for electricity utilities across the EU, manufacturers and suppliers of renewable energy equipment, current and potential co-partners in utility backed renewable electricity generation projects (e.g. Iand owners, water companies, investors etc.), energy consultants who provide services to the utilities, and policy makers in the EC and Member State governments. Each of these groups should derive tangible benefits from the pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'BREAKTHROUGH METHANATION TECHNOLOGY FOR ANY SOURCE OF CO2/CO' to be submitted under Horizon 2020.

assistant: **Abstract**

Renewable energy sources attract a mass interest to reduce carbon emissions and create a sustainable energy system for the future but storing the intermittent energy is one of their challenges. Methanation processes (converting CO2 into methane) are key enabling technologies because the output of the operation can be stored and transported through the natural gas transport infrastructure already in place and further reduce the “greenhouse” effect responsible for climate change through a circular economy approach. CoMeth, offers the disruptive technology that scales up the process of methanation for any CO2/CO source through a cutting-edge fluidized bed reactor containing nickel as catalyst, providing current providers of CH4 to the grid (Waste Water Treatment Plants and fermentation plants) considerable growth of production yield up to 60% from the same amount of biomass substrate, while avoiding the CO2 removal cost. In addition, these companies will increase their eco-profile as tool to raise both political support and societal acceptance. For the previous, TKE aims to revolutionize the renewable energy market by introducing CoMeth, the first commercial methanation technology for any source of CO2 gas which allows the conversion of surplus power into a grid compatible gas without complex gas conditioning, the automation of the process in larger scale and fitting all applications
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A step up in SOILL support for Soil Living Labs' under Horizon Europe.

assistant: **Concept**

As the second implementation project under the SOILL Framework, SOILL-Stepup aims to strengthen and expand the SOILL one-stop-shop structure by enhancing and consolidating services for Mission Soil Living Labs (LLs) and Lighthouses (LHs), while extending support to new applicants and aligned or emerging Europe-wide Soil LL/LH initiatives. Building on the foundations laid during SOILL-Startup (2024-2025), this follow-up project delivers targeted actions during SOILL’s 2026–27 period, directly supporting the Soil Mission’s Expansion and Innovation phase. This involves: 1) Enhancing the support structure through upgraded coordination, quality assurance, and alignment of support actions. The SOILL Hub will be further developed into a fully integrated collaborative platform offering information, training, monitoring and matchmaking. 2) Supporting LL/LHs across all stages of development—from setup to consolidation—via modular capacity building, personalised mentoring, and thematic guidance. Support will also extend to aligned and emerging initiatives with potential to grow in Soil LL/LHs. 3) Assisting new applicants through promotion of upcoming Mission Soil topics, mentoring, training, and matchmaking. A multilingual helpdesk, guidance tools, and tailored webinars will ensure inclusive support across all the eligible countries. 4) Mapping, evaluating and validating initiatives through harmonised monitoring and labelling system of Mission-funded, aligned and emerging LL/LHs. Annual assessments of network expansion will inform support actions and feed into policy recommendations. 5) Fostering collaboration and visibility through working groups, mutual learning events, international exchanges, and structured policy dialogues, strengthening community ties, knowledge sharing and