RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Protein Tyrosine Phosphatases: Structure, regulation and biological function', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

A major goal for cell biologists is to understand cellular signal transduction mechanisms, as this leads to comprehension of normal tissue biology and provision of more effective cures for disease. Most signalling pathways rely on reversible phosphorylation of amino acids and phosphotyrosine signalling in particular controls cell proliferation, differentiation and migration, and its dysfunction underlies many diseases. Protein phosphotyrosine is regulated through protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). In contrast to PTK research, which has generated insight into many diseases and provided many drug targets, the PTP field is younger and our understanding of PTP action remains relatively crude.Nevertheless, several PTP genes have recently been linked to diseases including cancer, diabetes, osteoporosis, hypertension, demyelinating disease and ulcers. Since PTPs now represent an exciting class of enzymes for drug targeting, it is urgent that we obtain a deeper understanding o f the molecular, cellular and tissue functions of these enzymes, under normal and pathologic conditions. The proposed network has scientific, technological and training objectives. We aim to rapidly define PTP structures, substrates and ligands, and define the signalling output of PTPs. We will then aim to relate this to the involvement of PTPs in human disease etiology and progression.This knowledge can then be exploited ultimately in the development of therapeutics targeted at PTPs enzymes. The PTP field is relatively small and geographically fragmented and a key objective is to bring together groups in Europe and Associate States, to deliver a highly interactive network that is interdisciplinary and intersectorial. This Network will be founded on the principal of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Mimicry of biology supramolecular logics towards self-assembly of artificial components for life'.

assistant: **Concept**

Whether a cell adheres to the extracellular matrix, or biological signals propagate within and between cells, highly selective interactions occur between the molecular ‘partners’ that materialize the process. Supramolecular chemistry studies the basic features of these interactions (knowledge) and their implementation for the design of non-natural systems (technology). This field bridges molecular chemistry and physics with biology, providing a interdisciplinary platform to understand biological structure (self-assembly) and function (recognition, reactivity and transport).Peptides that self-assemble in ordered nanostructures are a particular case of supramolecular chemistry. Peptides possess the biocompatibility and chemical diversity found in proteins, being particularly interesting for regenerative medicine and nanomedicine. Until now, peptide self-assembly systems have been studied individually. However, biological structures form in highly dense and heterogeneous molecular environments, such as the cytosol and extracellular matrix. The main scientific objective of this project is to recreate part of this complexity, by creating multi-component peptide self-assembly systems that form independent nano-assemblies in the same physical space. These systems will be used to provide technological solutions for the regeneration of ischemic neuronal tissues (artificial extracellular matrix) and the refined release of growth factors (capsules).These systems are also designed to be intermediate steps towards much more challenging future career objectives, namely cell-like bioreactors with the ability of protein production, self-maintenance or, even, self-replication. The beauty of this endeavor is that in the way towards such challenging scientific objectives, quite promising
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New packing and insulating materials from waste and rejected products', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The project aims to develop new rigid, semirigid and elastic packing and insulating materials suitable to substitute traditional petrol base materials by recycling, by means of physical/mechanical treatment, waste plastic and rubber end-life products coming from different industrial processes (such as the automotive industry or the shoe industry). The final result, will eventually consist in: - Substitution of actually used products with others coming from wastes of products made of petrol or of other natural resources with strong impact on pollution reduction; - Reduction of landfill disposal of wastes; - Reduction of energy consumption and environmental impact (gas, CFC etc.) - Reduction of the overall costs of transport, by using packagings with better properties (reduced volume); reduction of damages (thus, reduced number of scrap products), overall increase in efficiency. Initial experience made on some kinds of end-life products showed the efficiency of such materials with regard to the packing properties (mechanical resistance) but also to the insulating (thermal and acoustic) characteristics. Further researches and developments are envisaged to improve these promising characteristics and to extend the recycling process, by using new kind of wastes and producing new materials and products for different sectors of application
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Strongly Interacting Bose Gases' (SIBG) under Horizon 2020.

assistant: **Objectives**

This project addresses questions of emergent phenomena: How do remarkable properties of matter emerge from complex correlations between the atomic constituents? This is one of the current grand challenges in the physical sciences. Specifically, the research will focus on Strongly Interacting Bose Gases (SIBG). The Bose gas is of fundamental significance as a quintessential example of a quantum fluid. SIBG occur when interactions are maximized by a large scattering-length (of a similar magnitude to the interparticle spacing). In the unitary limit (divergent scattering length) all physical properties are expected to scale with the density. Recent experiments with ultra-cold quantum gases have observed that such a state can be created, and its properties accurately measured. Such experiments provide us with access to a remarkably clean and tunable realisation of a strongly interacting quantum many-body system. This is ideal for building up our understanding of many-body physics, which harbours some of the most difficult and relevant questions in the physical sciences. Currently, our theoretical understanding of SIBG is relatively undeveloped, and questions relating to their most basic properties lack consensus. In this project we will theoretically determine the thermodynamics and stability of SIBG. Within this proposal, we outline a set of highly innovative approaches designed to achieve these goals. Our theoretical models are based on an amalgamation of few-body and many-body approaches, for which the combination of; Experienced Researcher – Dr Sykes, and LPTMS supervisor – Dr Petrov, form a uniquely capable team. This research lies at the cutting-edge of strongly-correlated quantum many-body physics. The results will fundamentally advance our understanding of quantum fl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New states of Entangled Matter Out of equilibrium', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

When an extended quantum system is suddenly brought out of thermodynamic equilibrium all excitations collectively participate in the ensuing quench dynamics, causing a plethora of unconventional and exotic effects, in particular in low spatial dimensions where the effects of interactions and integrability are enhanced. The theoretical study of the non-equilibrium dynamics is hampered by the fact that the time dependent many-body wave function is highly entangled on spatial scales which rapidly grow in time. Consequently, a satisfactory description of the quench dynamics is a timely challenge whose solution cannot prescind from a precise characterisation of the entanglement content of the systems of interest.The ambitious goal of this proposal is to find and characterise new non-equilibrium states of matter guided by their entanglement content. Two parallel lines of research will help achieving this goal. One line concerns the study of some entanglement indicators like entanglement Hamiltonian, spectrum, negativity and relative entropies which, contrary to the entanglement entropy, are not yet widely used as tools for investigating many-body systems. The other line focuses on the study of some frontiers of non-equilibrium one-dimensional physics which include quantum quenches in spinful fermionic systems, the determination of the exact time dependence of correlation functions after a quench, and the use of integrable hydrodynamics for investigating transport in one-dimensional systems. Particular attention will be devoted to the experimental realisation of the proposed non-equilibrium protocols. The main tools to achieve these goals will be conformal field theories and integrability complemented by numerical simulations when the former two are not applicable.


**Keyword
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Milis, a novel sweet protein for use as flavouring in the food and beverage industry' (Milis), addressing dissemination and exploitation.

assistant: **Impact**

Excess sugar consumption is a major contributor to the alarming rates of obesity, diabetes, and dental disease that exist inmany developed countries. According to the Credit Suisse Research Institute, close to 400M people worldwide are affectedby Type II Diabetes. 4.8M people die of chronic disease every year, a number that is quickly rising. Costs to the globalhealthcare system are estimated at a staggering $470B per year, representing 10% of all the healthcare costs. Artificialsweeteners offer a non-caloric alternative to sugar but have health concerns of their own, and are not always effective inmaintenance of a healthy diet. However their use is not totally safe. Saccharine, for example, previously used on a largescale, was abandoned as soon as it was linked with development of bladder cancer. Artificial sweetener consumptionmodulates the gut microbiota and raises the risk of glucose intolerance. Sweet proteins that occur naturally in some tropicalplants can have a sweetness a thousand times that of sucrose. This indicates that proteins potentially represent novel lowcalorie,nutritious sweeteners – superior to either sugar or artificial sweeteners. However, producing naturally occurringsweet proteins on a large scale is challenging and limitations of their physicochemical properties will constrain theirapplication in the food industry.Milis Bio developed “Milis”, a novel protein which will be 200 - 500 times sweeter than sugar per gram. Milis presents lowcaloric content, no aftertaste, and no unhealthy chemical components. Milis allows the consumer to think only about howgreat their food tastes, rather than worrying about what’s in it. Using a protein as a flavouring guarantees that the ingredientwill be low-calorie, easily digestible, and suitable for diabetics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Enlarging fuel cells and hydrogen research co-operation' to be submitted under Sixth Framework.

assistant: **Abstract**

The work will last 24 months and will be structured in 5 operative Workpackages. During WP1. the Polish, Czech and Slovak Partners will work in their respective countries on the expertise localisation and mapping, establishing contacts with Universities, C entres of Excellence, research organisations, etc., At the same time, the Italian and Belgium partners, will involve key experts in the targeted sector from the member states. The objective of WP2. will be to analyse the state of the art, the existing barr iers and needs for research successful performance in the field of fuel cells and hydrogen energy in the targeted candidate countries; Then, from the beginning of the third month of the project duration, the Enfugen virtual platform and database, containin g the list of research organisations and individual experts, will be implemented. The most interesting profiles collected during WP1, will be invited to enter the scientific forum. which activities will be developed in the reserved area of the Enfugen virt ual platform. WP3 will consist in stimulating the researchers' interaction through virtual multi-session roundtables to work on possible ideas for IP/NoE, as well as, trough traditional workshops within RE events in Poland, Czech and Slovak Republic, so as to create awareness among, and synergies with, the researchers operating in the field of RES. The WP4 will provide assistance to research performers by training activities based on transferring the European best practices, successful models stimulating en trepreneurial skills, as well as by brokerage activity* to assist the researchers in building industrial partnership for the targeted NoE/IP. The WPS will consist in dissemination of Enfugen results and planning successful exploitation of the Enfugen model so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Role of LINE-1 retrotransposons in the human disease DiGeorge Syndrome' (L1-DIGEORGESYNDROME) under Seventh Framework.

assistant: **Objectives**

Long INterspersed Element 1 (LINE-1s or L1s) is a highly abundant retrotransposon comprising 17% of the human genome. Most L1s are retrotransposition defective, but there are approximately 100 full-length active L1s (RC-L1s) in an average human genome. The activity of RC-L1s impacts the human genome in a myriad of ways, and several human diseases have been caused by the activity of L1s.The Drosha-DGCR8 complex (microprocessor) has a well-characterized role in microRNA (miRNA) biogenesis. DGCR8 contains two double-stranded RNA binding motifs that recognize the RNA substrate, whereas Drosha functions as the endonuclease. The microprocessor complex process pri-miRNAs that are further processed by Dicer in the cytoplasm to generate the mature miRNAs, which participate in several biological processes.In work I conducted as a post-doctoral fellow, we demonstrated that the microprocessor complex regulate LINE-1. Briefly, we demonstrated that the microprocessor complex could process primary transcripts resembling the 5’UTR of RC-L1s. Using a cell based L1 retrotransposition assay, we also observed that the microprocessor complex negatively regulates L1 mobilization. Thus, these results suggest that the microprocessor complex may act to regulate L1 retrotransposition, as a defender of human genome integrity.Notably, the human disease DiGeorge Syndrome (DGS) is characterized by the loss of the human gene DGRC8. Briefly, DGS affects between 1/2000 and 1/4000 live births, and most importantly it is one of the most common causes of mental retardation. The disease affects many parts of the human body (birth defects, learning disabilities, and recurrent infections).The Garcia-Perez lab has established that L1s are expressed and mobilized during early stages of human embryonic developm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Repair of DNA lesions induced by platinum drugs' under Horizon 2020.

assistant: **Concept**

DNA damage-inducing platinum drugs, such as oxaliplatin and cisplatin, are used to treat about half of all patients receiving chemotherapy. Although potentially very efficient, many patients develop resistance for yet unrecognized reasons. Better understanding of the DNA damage response (DDR) to platinum-DNA lesions is therefore much needed for improving treatment outcomes.  By performing DDR-dedicated CRISPR/Cas9 knockout screens, the applicant has shown that some cancer cells deficient in the major repair of bulky DNA lesions, global-genome nucleotide excision repair (GG-NER), are insensitive to oxaliplatin but sensitive to cisplatin. This striking difference remains as of yet unreported, but might explain differential responses of tumors to drugs. The aim of this proposal is to understand why GG-NER is unable to repair oxaliplatin lesions in particular genetic backgrounds. To do so, unbiased identification of genes differently mutated or expressed in oxaliplatin-sensitive versus insensitive cells will be followed by validation and in-depth functional characterization of identified targets. The ambition is to extrapolate experimental observations to translational knowledge. Validated targets will be studied in patient-derived tumor tissues as compared to nonmalignant tissues and related to patients’ treatment responses. Identification of genetic factors that regulate platinum lesions recognition by GG-NER will contribute to the understanding of molecular principles of platinum drugs cytotoxicity and might thus have considerable benefit on current cancer treatment schemes.The novelty of the pilot data, the unique multidisciplinary design of the project, the use of state-of-the-art molecular techniques and a collaboration with multiple European experts will ensure high
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'smart childhood Obesity CARing solution using IoT potential' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Child obesity is the major pediatric public health concern, affecting around 224 million school-age children in the world. Its prevalence has tripled in many European countries since 1980, increasing in an alarming rate. Childhood obesity already affects more than one in three school-aged children in Brazil, Greece and Spain. The main goal of OCARIoT is to promote the improvement of eating and physical disorders and also the prevention of the obesity onset for children (between 9 and 12 years old). For doing so, OCARIoT will develop an IoT-based personalised coaching solution guiding children to adopt healthy eating and physical activity behaviour. The IoT network will allow observing child activity patterns of daily living, health evolution, physiological & behavioural parameters and environmental data. All this information combined with medical patterns will allows OCARIoT to provide a customised obesity coaching plan while enabling children to remain active and engaged in their well-being and healthy habits management. The proposed solution will be able to empower children (and also educational staff and families) in taking control of their health by collecting real-time information about nutrition and physical activity, and interconnecting doctors and children (including parents and tutors) in order to adapt the individual obesity coaching plan. OCARIoT will demonstrate and validate its results on three specific pilot sites in Spain, Greece and Brazil. The OCARIoT consortium will ensure children’s rights and data privacy, security and confidentiality through an Ethics Board composed by healthcare professionals and children representatives from different EU and Brazil organisations.