RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ChemCatSusDe: Chemical Catalysis towards a Sustainable Development: Transformation of Bio-Resources and Atom-Efficient Reactions Catalyzed by Bio-Metals' (ChemCatSusDe).

assistant: **Innovation**

ChemCatSusDe addresses some of the industrial and economical issues of our society: fossil fuel depletion, use of renewable resources derived from the biomass, environmentally friendly chemistry for a sustainable future. At its core lies the versatility of complexes of zinc, magnesium, calcium, strontium and barium (the so-called bio-metals): green catalysts able to perform both the polymerisation of cyclic esters and highly atom-efficient hydroelementation reactions will be designed.The objectives defined by the researcher and the host institution in Rennes are:- Synthesis of well-defined complexes of the large alkaline-earth (Ca, Sr, Ba). The coordination chemistry of these metals in the presence of chelating, mono-anionic ligands will be studied. Owing to the extreme oxophilic nature of these elements, these catalytic precursors are expected to display excellent activities. The same synthetic strategies will also be extended to the preparation of complexes of the smaller zinc and magnesium, which display an excellent compromise between stability and catalytic activity- Use of these complexes for the catalytic immortal ring-opening polymerisation of cyclic monomers derived from renewable bioresources for the production of biocompatible and/or biodegradable polymers. All catalysts will be used for the polymerisation of lactide and monomers such as morpholinediones and b- or g-valerolactones- Hydroelementation of terminal alkenes catalyzed by heteroleptic amido-alkaline-earth complexes. Catalysts for the 100% atom-efficient hydrosilylation, -phophination and -amination of unsaturated substrates will be prepared- Study of the stability and reactivity of the targeted heteroleptic complexes by theoretical calculations: the design of catalytic systems will be elaborated and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'OvaRenew as a first-line therapy in impaired egg quality treatment' in the context of a Horizon 2020 call.

assistant: **Objectives**

Potenza Medica Ltd. is specialised in the development and commercialisation of innovative fertility products. Our solution is tackling one of the deepest human needs-reproduction. With OvaRenew as a first-line therapy in ovarian infertility, we intend to grab business opportunity to be the first in the world with disruptive fertility solution for women with impaired egg quality. Global fertility services market was in 2015 estimated to be between 27-36 billion € with growth rates of 8-9% in EU and 4% in US. The novelty is in innovative combining of new findings in fertility and nutritive science, which will revolutionize current industry practice. OvaRenew is based on disruptive findings of stem cells in ovaries that are able to transform into oocytes under defined conditions. Those will be initiated through the substances, administered orally. So far, there is no effective and practical strategy available for impaired egg quality. They all are highly invasive with significant health complications, expensive, not focusing in helping woman to produce genetically own child. OvaRenew will enable women with impaired egg quality to produce their own child while drastically decreasing cost and invasiveness of the procedures on one and country health and other expenditures on the other hand. In 2 years (Phase2), OvaRenew can be prepared for global commercialisation. With 1 mio € investment, final product is planned to be introduced on global markets, with focus on developed world. In Phase 1, a feasibility study will be performed with focus on risk assesment and IP protection. While we are operating in one of the most regulated industries, in close dialogue with regulators, we will assure alignement for safety and regulatory requirements such as those pertaining to cell procur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Principles of Learning in a Recurrent Neural Network' in the context of a Horizon 2020 call.

assistant: **Objectives**

Forming memories, generating predictions based on memories, and updating memories when predictions no longer match actual experience are fundamental brain functions. Dopaminergic neurons provide a so-called “teaching signal” that drives the formation and updates of associative memories across the animal kingdom. Many theoretical models propose how neural circuits could compute the teaching signals, but the actual implementation of this computation in real nervous systems is unknown. This project will discover the basic principles by which neural circuits compute the teaching signals that drive memory formation and updates using a tractable insect model system, the Drosophila larva. We will generate, for the first time in any animal, the following essential datasets for a distributed, multilayered, recurrent learning circuit, the mushroom body-related circuitry in the larval brain. First,  building on our preliminary work that provides the synaptic-resolution connectome of the circuit, including all feedforward and feedback pathways upstream of all dopaminergic neurons, we will generate a map of functional monosynaptic connections. Second, we will obtain cellular-resolution whole-nervous system activity maps in intact living animals, as they form, extinguish, or consolidate memories to discover the features represented in each layer of the circuit (e.g. predictions, actual reinforcement, and prediction errors), the learning algorithms, and the candidate circuit motifs that implement them. Finally, we will develop a model of the circuit constrained by these datasets and test the predictions about the necessity and sufficiency of uniquely identified circuit elements for implementing learning algorithms by selectively manipulating their activity.Understanding the basic func
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Exciton complexes bound to interface defects in shallow quantum wells' (1994-1998) under Fourth Framework.

assistant: **Objectives**

In the last year charged excitons and biexcitons came in the center of interest. I will investigate theoretically the charged excitons and bi-excitons bound to interface defects in shallow quantum wells. They seem to play an important role in the evolution of the optical response of quantum wells for increasing excitation or carrier concentration. The charged exciton for example appears to play a decisive role in doped quantum wells: He holds for varying carrier concentration an intermediate position between the regular exciton and the Coulomb correlated electron-hole-pair. A further unanswered question is whether the charged excitons and bi-excitons are bound or free. Based on the theoretical results for strongly confined quantum dots I will analyse their binding energies. I plan to study the stability of the charged excitons and bi-excitons in shallow quantum wells by means of variational calculations. My objective is to see if the binding energy is compatible with available experimental findings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ChemCatSusDe: Chemical Catalysis towards a Sustainable Development: Transformation of Bio-Resources and Atom-Efficient Reactions Catalyzed by Bio-Metals', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

ChemCatSusDe addresses some of the industrial and economical issues of our society: fossil fuel depletion, use of renewable resources derived from the biomass, environmentally friendly chemistry for a sustainable future. At its core lies the versatility of complexes of zinc, magnesium, calcium, strontium and barium (the so-called bio-metals): green catalysts able to perform both the polymerisation of cyclic esters and highly atom-efficient hydroelementation reactions will be designed.The objectives defined by the researcher and the host institution in Rennes are:- Synthesis of well-defined complexes of the large alkaline-earth (Ca, Sr, Ba). The coordination chemistry of these metals in the presence of chelating, mono-anionic ligands will be studied. Owing to the extreme oxophilic nature of these elements, these catalytic precursors are expected to display excellent activities. The same synthetic strategies will also be extended to the preparation of complexes of the smaller zinc and magnesium, which display an excellent compromise between stability and catalytic activity- Use of these complexes for the catalytic immortal ring-opening polymerisation of cyclic monomers derived from renewable bioresources for the production of biocompatible and/or biodegradable polymers. All catalysts will be used for the polymerisation of lactide and monomers such as morpholinediones and b- or g-valerolactones- Hydroelementation of terminal alkenes catalyzed by heteroleptic amido-alkaline-earth complexes. Catalysts for the 100% atom-efficient hydrosilylation, -phophination and -amination of unsaturated substrates will be prepared- Study of the stability and reactivity of the targeted heteroleptic complexes by theoretical calculations: the design of catalytic systems will be elaborated and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Metallic cultural heritage: improvement of means of measurement on archaeological copper-allys for characterization and conservation' (1994-1998).

assistant: **Innovation**

Due to the increasing number of locations and methods of analyses, due to the lack of Reference Materials specially concerning the elemental composition of archaeological copper alloys, due to the non-traceability and non-comparability of the published results, any reliable historical reconstruction on statistical ground is hopeless.The aim of this project is to make available reliable tools for achaeometers and for researchers in the field of conservation. These tools are:- Certified Reference Materials for calibration of bulk elemental analysis of ternary and quaternary copper alloys.- A good analytical-practice guide for the use of EDXRF for the study of the bulk elemental composition of archaeological metallic artefacts.- A good analytical-practice guide for the study of the surface of artefacts in cases where the investigation should be non-destructive.- Assessment of the limits of the correlation between outer (corroded layers) and inner (uncorroded layers) composition- Improvement and optimization of the electrolytical methods available to monitor corrosion behaviour.Five Certified Reference Materials representing the main families of metals found in Antiquity from the very beginning of metallurgy until the Roman Period, will be fabricated: copper being the base metal: impure copper, arsenical copper, tin-bronze, leaded bronze, and tin. The impurities contained in the ancient metals will be reproduced taking into consideration the problem of homogeneity.At this stage the IFAO, EDF and SEK have been working on the determination of the first two compositions. IFAO prepared a bibliography including 203 objects and analyzed 200 other objects from Egypt and the Eastern Mediterranean which gave a suggestion for the first composition for a Reference Material: this compo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Increasing access for european researchers to systematics resources and analytical facilities' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The Natural History Museum (NHM) is one of the world's leading centres for taxonomic research. SYS-RESOURCE Project NHM offers access to: · A collection of over 70 million natural history specimens, including 800,000 types and a world class natural history library of over 1 million volumes· Internationally-renowned taxonomic and systematic skill base of more than 320 researchers, curators and technicians· The opportunity to utilize rare collection material for molecular, chemical and image analysis. User will have access to the top class laboratory facilities on- site · Complementary collections and facilities at the Linnean Society, London and Royal Botanic Gardens, Kew.SYS-RESOURCE offers a multi-disciplinary approach to the applied use of the collections and taxonomic knowledge. Users who are allocated access awards will be mentored by NHM's permanent staff and will work alongside other visiting scientists and be given an opportunity to present their work at NHM. There will be two calls for proposals per year. Candidates may apply using the on-line application form available on the web site: http://www.nhm.ac.uk/science/rco/sysresource/index.html or by requesting a Word version or hard copy format from the Project Manager (Vanessa Pike, email v.pike@nhm.ac.uk).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Scalable Manipulation Learning through AR-enhanced Teleoperation enabling Intuitive Interactive Instructions' (SMARTI3).

assistant: **Concept**

SMARTI3 addresses three pivotal visions in robotics: enabling robots to handle diverse objects in complex scenes, manipulate objects with varying geometries and physical properties, and interpret and follow intricate instruction manuals. While AI is predestined to realize these visions, its  promises to fulfill these visions have not been fully realized yet. Despite significant breakthroughs of AI in many domains, robotics has not seen a parallel surge, primarily due to challenges in task-specific data collection, the high demand for training data, and the extensive expertise required for applying AI in robotics.Our innovative approach integrates intuitive data generation, fine-tuning of foundational knowledge, leveraging human feedback for continual self-improvement, and incorporating offline instructions with semantic and geometric information into skill, perception, and prediction models. Our objectives are to streamline the generation of human and synthetic data for robot learning, develop few-shot adaptable foundational representations, scale-up robot skill-learning capabilities, and enhance learning from interactive human feedback and offline instructions.The project showcases its advancements through three use cases that mirror future industrial applications: sorting and disassembling a variety of Lego pieces, origami folding from visual instructions, and assembling complex Lego structures from unsorted pieces using instruction manuals. These cases highlight our approach's adaptability and potential for industrial application.SMARTI3 aims to revolutionize robotic skill, perception, and prediction models, significantly broadening the scope of robotic technology in various industries. This groundbreaking project lays the foundation for a new era of intelligent, ada
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Dissecting the molecular pathogenesis of Legionella spp. in human lung models'.

assistant: **Concept**

Aging populations and the increasing use of immune modulatory medical treatments have given rise to a growing incidence of opportunistic infections. Legionella species are Gram-negative environmental bacteria, which after accidental inhalation can cause respiratory infections with symptoms reaching from a mild flu to a severe pneumonia, called Legionnaires’ disease. Disease progression, i.e. clearance or exacerbation of infection, is determined by the immune status of the host and acute pneumonia usually associated with immune suppression and/or underlying pulmonary conditions, but the molecular mechanisms enhancing susceptibility are poorly understood. The infection biology of Legionella has been studied mostly in cellular infection models and mice, which do not develop human-like disease. As patients typically present only at late stages of infection, it is unclear to which extent findings from these models reflect the early processes which occur in the human lung during infection and how these drive the clinical outcomes. Similarly, these models fail to explain, why L. pneumophila serogroup 1 strains are the predominant cause of more than 90% of Legionnaires’ disease cases.In this project I, the applicant Dr. Flavia Viana, will tackle these knowledge gaps by establishing and using human precision cut lung tissue slices (hPCLS) and excorporeal perfused whole human lungs (Ex vivo lung perfusion (EVLP)) as infection models for Legionella. I will determine if and how virulence of different Legionella isolates in these models correlates with their relevance in the clinical practice, analyse the transcriptional responses of all cell types in the infected human tissue using single cell transcriptomics and employ histology, state-of-the-art confocal and light sheet live micr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Breaking the Mould: A cross-cultural analysis of the character of bronze smiths and craft diversity in late Bronze Age Europe (1300-800 BC)' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

During the late Bronze Age in Europe (c. 1300-800BC) there was a transition in metal consumption from a restricted-access prestige material to a common medium for making practical objects. The objective of this project is to characterise culturally particular developments in bronze workshop practices using case-study areas in Europe, and through this to rethink relationships linking resource control, craft organisation and identity formation. This is achieved by measuring variability in the technological choices, skillsets and knowhow underlying smithing traditions and defining the social practices of craft production. I will employ a cross-cultural approach using three case studies: the Balkans, Central Europe and Northwest Europe. Multidisciplinary diagnostics will be used to assess technological markers that reveal intentional differences in production techniques. Methods will include 1) collating and analysing metallurgical datasets 2) recording and 3D modelling of craft traces on artefacts, 3) experimental bronze casting and material analysis. I will use these to build the first pan-European metallurgical digital resource, making specialist data more accessible and better enabling international collaborative actions. By moving to UCD, I will work closely with Aidan O’Sullivan, director of the Centre for Experimental Archaeology and Ancient Technology. Resources there and in the School of Archaeology provide a unique constellation for training in bronze object casting, forging and mechanical testing, along with digital 3D rendering of artefacts and data management. My career goal is to be a research leader in experimental archaeology, which this project will enable by developing a novel integrated kinaesthetic and scientific method for the study and visualisation of