RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multi Atomistic Monte Carlo Simulation of Technologically Important Crystals' in the context of a Seventh Framework call.

assistant: **Objectives**

In order to continue with the size reduction of transistors it is necessary to use complex implantation conditions such as amorphizing implants. Models predicting the resulting dopant profile reduce the number of experiments necessary to design the best process to obtain the desired properties. In the case of development of materials for fusion applications, models are crucial since, as of today, there are no experimental facilities to reproduce the same conditions that the materials will withstand in a fusion reactor. Therefore, extrapolations must be made from different irradiation conditions (fission reactors or ion implantation). These materials are different, but the basic mechanisms are the same: production of defects, diffusion of these defects and interaction with other defects, impurities or the material microstructure. In the case of microelectronics these effects must be followed for a time scale of minutes, while in fusion it is necessary to model years of operation. Using the atomistic Object and Lattice Kinetic Monte Carlo techniques (OKMC, LKMC), tools that can achieve the scales and ranges involved, this project improves the scientific understanding, generates efficient models for technology development and provides a simulation workbench to optimize the use of SiGe, SiC (microelectronics) and Fe, FeCr (nuclear). Several atomic configurations will be included in LKMC to study the amorphous/crystalline transitions of Si-based materials and the formation of defective crystals during the transition. Binary alloys will be included in a OKMC scenario to study the evolution of defects under different conditions, to be used for SiC, SiGe and FeCr materials. Finally, parallelization techniques will improve the scope of KMC applications. The knowledge gain with t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Harmonization of European MET Schemes' in the context of a Fourth Framework call.

assistant: **Objectives**

i) To contribute to the development of harmonized syllabuses and how those could be implemented ii) To identify needs for the adaptation of MET programmes to the requirements of the maritime industryiii) To assess the impact of modern teaching technology on MET iv) To provide for better understanding of the new STCW Convention and suggest a harmonized approach to the meeting of the Convention requirementsv) To enhance the employability and facilitate the professional mobility on MET graduates within the maritime industry and within European countriesvi) To increase the competitiveness of the European maritime industry by helping to improve the qualifications of seafarers and other maritime personnelLinks with other projects, tasks, areas, programmes, policy actions:To 6.4 Human Resources and related projects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Beyond Bones: Integrating Statistics and Machine Learning Tools into Archaeological Evidence to Decode Neanderthal-Carnivore Scenarios' (BITES) under Horizon Europe.

assistant: **Objectives**

The relationship between humans and their natural environment has significantly shaped our evolutionary history. Carnivores in particular, our main competitors in many past ecosystems, likely had a profound impact on hominin behaviours. Neanderthals, potentially more carnivorous than other hominin species, present an intriguing focus. Were the relationships between Neanderthals and carnivores primarily rooted in rivalry, mutual avoidance, or subtle survival adaptations? How did they impact Neanderthal niche exploitation? Can changes in these interactions shed light on Neanderthal disappearance? Archaeological sites yield thousands of animal bone fragments with traces of Neanderthal and carnivore consumption that offer valuable insights into this coexistence. Yet, these data remain underexploited, due to the challenges derived from interpreting complex mixed taphonomic processes. The BITES project aims to reconstruct Neanderthal-carnivore interactions using targeted quantitative methodologies, which are tailored to detect patterns previously unattainable with traditional approaches. Employing both multivariate statistics and machine learning, I will initially accurately quantify hominin and carnivore relative activities across four Middle Paleolithic sites in Iberia set in different environments. Subsequently, reusing literature data, the project will build statistical and machine learning models to identify the main interaction type in previously studied sites, including scavenging, avoidance, and competition for prey. Lastly, the project will explore any environmental, spatial, or temporal shifts in these interactions and their potential correlation with settlement patterns and the eventual disappearance of Neanderthals. The findings derived from bridging cutting-edge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Improved cancer risk quantification for environmental, medical and occupational exposures to low doses of ionising radiation by mechanistic models' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

This project will contribute to the solution of the important open problem of quantification of stomatic radiation risks to humans at low doses (below, say, 10 mSv) and low dose rates of ionising radiation of various qualities at least for the organs lung, thyroid and bone. Since this problem cannot be solved by basic biological investigations nor by epidemiological studies alone, the scientific knowledge from both areas will be combined to develop and test quantitative mechanistic models for the dose-time-effect surfaces of radiation carcinogenesis in these organs. Existing data and theories are evaluated and used for the modelling of radiation transport and interaction, for the modelling of subsequent damage and repair of DNA, genes, cells and organs taking normal oxidative damage into account, and for the multi-step modelling of carcinogenesis. Conclusions will be drawn for the general radiation of the worker and the public.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Controlling frequency-comb fast-gain devices through photonic lattice engineering' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Optical Frequency Combs (OFCs), states of light with equally spaced and phase-locked frequencies, revolutionized metrology across a wide range of metrological applications. Current OFC sources are highly accurate but also bulky. Miniaturizing OFC sources to on-chip scale, small enough to be placed in your hand, will enable a second revolution with applications such as distributed pollution tracking, medical detection equipment, compact LIDARs and dense communication channels (DWDM). OFC devices supporting these applications require:(a) in-situ control over the spectrum with power management of ~90% for every spectral line(b) bandwidth of 10-15THz (c) power per line of ~3mW while maintaining wall plug efficiency of >20%In LIQUIDLAT I will develop on-chip OFC devices with (a)-(c), by taking a new approach and leveraging on the recently demonstrated, by me and coauthors, quantum walk comb: generate monolithic lasers with fast gain recovery and apply photonic lattice schemes, both in real and frequency spaces through inter-device coupling and modulation, for controllable, broadband and powerful OFCs. This method is general and can be implemented in other wavelengths.Unlike current on-chip OFC approaches, typically producing pulses, I will use the following elements:(1) fast gain recovery that forces quasi constant intensity and grants the light liquid properties, stabilizing on broadband and stable states(2) direct control over OFC expansion via modulation by radio-frequency sources(3) use topological photonic lattice schemes, both in real and frequency domains, to lock coherently many OFCs to a single powerful output.The study of liquid light dynamics in photonic lattices challenges our understanding of nonlinear dynamics and interaction in semiconductors. The outcome is t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Modern and past grass-dominated biomes distribution recorded by phytoliths and stable carbon isotopes; calibration and modelling' (GRADING) under Sixth Framework.

assistant: **Objectives**

Nowadays grasslands are the most widespread continental floral associations. They were more abundant than today during the different past glaciations. Although proxy indicators of past environments can be derived from fossil records, the reconstruction of grass-dominated biomes is difficult as pollen cannot distinguish between grass subfamilies. The main objective of this project is focused on the Quaternary dynamics of grass-dominated biomes in South America and Colombia in particular, in order to better u nderstand the relationships between climate change and vegetation dynamics (e.g. C3/C4 grass distribution) in tropical areas. For this purpose, quantitative data and vegetation models will be coupled. Calibration of statistical relationships between modern phytolith assemblages, stable carbon isotopic signatures of modern soil derived organic carbon, botanical statements for several grassland biomes and climate data will be performed. Regression equations between climate parameters, the quantitative phytoli th and d13C proxy of C3/C4 grasslands will be estimated. In a second stage, we will apply the calibrated relationships to several soil profiles from several elevation transects where the change in C3/C4 grass dominance over the last 10,000 years has been r ecorded. Finally, the reconstructed vegetation and climate parameters will be compared with several scenarios derived from two vegetation models (BIOME 3 and LPJ-GUESS). This process of data-model comparison will include investigating changes in precipitat ion, temperature and atmospheric CO2 concentrations. The comparison between simulation and data enables in turn, by inversion of the model, to reconstruct the parameters best as coherent as possible with the data. The application and development of the phy tol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Structural and Metabolic connection in oceanic plastid symbioses' in the context of a Horizon Europe call.

assistant: **Objectives**

Single-celled marine plankton, that sustain oceanic food webs and strongly impact the global carbon cycle, can establish various kinds of symbioses to gain energy. Plastid symbiosis, whereby host cells temporarily integrate microalgal cells (photosymbiosis) or just their photosynthetic plastids (kleptoplastidy) as intracellular solar-powered carbon factories, is a key interaction in worldwide surface oceans. Plastid symbiosis was at the origin of a major evolutionary innovation that spread photosynthesis across eukaryotes, transforming the biosphere. Despite this ecological and evolutionary importance, very little is known about how a photosynthetic machinery is structurally and metabolically integrated into a host cell and what mechanisms allow cells to transport sugars, the main photosynthetic product and energetic currency. The central concept of SymbiOcean is that plastid symbiosis forms a metabolic unit where the source (engulfed microalgae/plastid) is metabolically engineered by the sink (host) to produce and transfer carbon energy. Working with original non-model symbiotic systems, I will develop novel imaging and genetic tools to mechanistically dissect this key metabolic interaction at different scales. Combining multimodal subcellular imaging and photophysiology, I will first unveil how the photosynthetic machinery is morphologically and metabolically remodeled in symbiosis to provide benefits to the host. I will then investigate the identity, localization and role of sugar transporters underlying the source-sink carbon flux in plastid symbiosis, providing the basis to evaluate the evolutionary and environmental forces that shape the metabolic connection. Crossing boundaries between structural biology, eco-physiology and evolution, this ambitious project will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Conflict Resolution, Mediation and Restorative Justice and the Policing of Ethnic Minorities in Germany, Austria, and Hungary""', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The proposed research will use a comparative design (Germany, Austria, Hungary) to establish whether better police - minority relations can be achieved through means of a Restorative Justice (RJ) approach. The extent and cultural particularities of RJ programs and their affiliation to the criminal justice system will be ascertained. Then specific minority populations (Turks in Germany, Roma in Hungary, Africans in Austria) will be examined in regard to the country’s security context. The involvement of police in RJ programs for minority populations will be explored. Finally, the proposed research will exemplify the scope of RJ approaches for the improvement of police - minority communication and interaction.Based on the legality principle and on an inquisitorial civil law tradition of policing and criminal justice, the partner countries’ legal and policing systems differ substantially from the Anglo-American-Australian hemisphere of restorative justice. The findings will have a wider impact on the Middle and Eastern EU situation. The research will include open questions of gender, age and cultural compatibility of RJ. With positions at police universities the researchers are well grounded in police science and have carried out previous work on minorities. This grants them access to the field and to practical areas of police work and management. Their principal involvement in B.A./ M.A. programs for police officers and in CEPOL/EUSEC research secures dissemination into police and the scientific community.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Synthetic Biology of mRNA' (NEWmRNA).

assistant: **Concept**

mRNA is a major actor in the expression of cellular information, but we can only wield it in the very narrow boundaries imposed upon us by the transcriptional machinery and our lack of knowledge of the chemical scope of mRNA translation inhuman cells. Given the diverse role of mRNA in major life science applications from vaccination via gene therapy, chemistry, and diagnostics to pest control in agriculture, we argue that we are missing a huge opportunity to improve the outcome of medical therapies, broaden chemical catalysis, advance medical diagnostics, and reduce the human footprint in agriculture. With a focus on medical applications, NEWmRNA proposes to follow a synthetic biology approach to redraw the chemical map of the translation of mRNAs in human cells and at the same time to transform biological mass production of mRNAs. In the course of the project, we will implement a novel cellular assay to rapidly assess the impact of non-canonical forms of mRNA on translation and cellular signaling, re-engineer enzymatic mRNA synthesis via T7 RNA polymerase, introduce the concept of cloaked bioproduction in bacteria – the production of protected forms of instable molecules, coupled to enzymatic recovery post production – and introduce crucial steps for industrial-scale production of mRNA.


**Keywords:** gene therapy, vaccination, orthogonal systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Testing of special transport equipment for wheelchair users'.

assistant: **Objectives**

To improve the integration of wheelchair users in society, a better integration of mobility aids, means of transport and transport devices and systems is needed. This integration can only be realised by the process of standardisation of all related products. Standardisation is required, in particular, for three groups of devices that represent the links with the various means of transport and systems and, consequently, play a crucial role in the transport chain for people using a wheelchair for their independent mobility:wheelchairs used as seats in motor vehicles,wheelchair tie-down and occupant restraint systems for motor vehicles,stair climbing devices (for taking wheelchairs up and down stairs).The objective of the project is to provide a knowledge basis for the development of a CEN/ISO standards specifying performance criteria, safety requirements, test methods and test equipment for three groups of devices mentioned above.Field studies have been carried out to evaluate the daily practice of wheelchair users and transport service personnel. In particular, it has been examined how different types of wheelchairs are restrained and how stair climbing devices are used in practice. Once the requirements have been established, experiments will be carried out to detect potential hazards, in particular with stair climbing devices.The safety and usability aspects of special transport equipment for wheelchair users will be analysed and transposed to standardisation requirements, test methods and test equipment. The requirements and test methods will be validated by testing a representative sample of the current market for each of the three types of devices. Industry will be involved by means of workshops and by using the extensive network of all the partners, built on many y
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structure/function studies on the activation of the met receptorprotein-tyrosine kinase' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content Met is a receptor tyrosine kinase that elicits multiple biological responses including cell growth, scattering and tubulogenesis The autophosphorylation of two neighbouring tyrosine residues Y1234 and Y1235 in the kinase domain upregulates catalytic' activity and results in the phosphorylation of two tyrosines located in the cytoplasmic C-terminal tail Y1349 and Y1356 the mediates high affinity interactions with the SH2 domains of a number of signal transducers. Met is overexpressed in; significant number of carcinomas and is amplified in metastases. A direct genetic connection between Met activation an/ human cancer was demonstrated recently by the identification of causal mutations in the Met kinase domain for hereditary and sporadic papillary renal carcinomas (PRC). Some of these mutations have been shown to constitutively activate the receptor and when expressed in fibroblasts, form foci of transformation. Furthermore, all of the Met papillary renal carcinoma mutation are tumourigenic in nude mice. Therefore, single mutations have been identified in MET that convert the proto-oncogene to an oncogenic counterpart. The aims of the proposed study are: (1) to analyse the signalling pathways used by the Met receptor harbouring PRC mutations; (2) to define the structural basis for the oncogenic activation of the Met kinase by the resolution ofthe crystal structures of the wild-type and mutated Met tyrosine kinase domains. Training content (objective, benefit and expected impact) The objective of the candidate is to gain experience in the research of receptor tyrosine kineses and intracellular signalling pathways and their relation to human neoplastic disease. Dr. Tracy Williams will benefit from working in a research laboratory with a disti