RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Targeted Antigen deLivery to Langerin: molecular basis of recognition and its implication in antigen uptake, processing and presentation to T cells' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The skin is an attractive target in human vaccination harboring a dense network of immune cells. For instance, Lagerhans cells (LCs) are specialized in the identification of antigens derived from pathogens, and their subsequent internalization and presentation to induce a T cell response. The aim of the present proposal is to establish a novel mechanism for antigen delivery, targeted specifically to a particular receptor of LCs, Langerin, capable of triggering a T cell response. To this end, the vaccine scaffold will be composed of a T cell stimulating peptide covalently linked to a glycomimetic probe aiming exclusively to Langerin. This project gathers the use of several techniques derived from both chemistry and biology at the disposal of immunology. First, molecular docking of the binding groove in complex with the antigenic peptide will be crucial to rationally design the vaccine scaffold. Once chosen, the most suitable candidate will be synthetized and analyzed by a combination of different Nuclear Magnetic Resonance (NMR) techniques. Elucidation of the antigen-Langerin affinity using NMR experiments will be critical to choose the most specific antigen to be further employed in biological tests. Antigen uptake will be monitored by flow cytometry and confocal imaging. Whole skin cell suspensions will be then employed to test the specificity of the construct. Finally, antigenic peptides will be tested for T cell activation and proliferation. The translational outcome of this research will be applied in the design of transdermal patches, which represent an attractive approach to intramuscular vaccination, allowing targeted and pain-free delivery with minimal invasiveness.


**Keywords:** langerin, molecular recognition, peptide chemistry, carbohydrates
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Transition metal carbides as efficient catalysts for methane partial oxidation' (TMC4MPO).

assistant: **Concept**

Methane is a particularly problematic greenhouse gas as its impact is 25 times greater than carbon dioxide over a 100-year period. Human activity has increased the amount of methane in the atmosphere, contributing to climate change. Therefore, there is an imperative for the transformation of methane into useful chemicals. At this time, the most economically available route for the conversion of methane into more valuable chemicals is via synthesis gas, a mixture of CO and H2. The only large-scale process for natural gas conversion involves a reaction known as methane-steam reforming. However, it is an endothermic process that requires high operating temperatures. Methane partial oxidation (MPO) is a promising energy saving alternative because it does not require the use of superheated steam. A major goal is to find a catalyst that exhibits high activity, selectivity and stability at the relevant reaction conditions.This project envisions the computational prediction of novel MPO catalysts that overcome this challenges by computationally screening a large set of materials consisting of precious metals (Rh, Pd, Pt, Au) and more affordable metals (Co, Ni, Cu) supported on transition metal carbides (TMCs, TM = Ti, Zr, Hf, V, Nb, Ta, Mo, W). These type of catalysts have exhibited outstanding performance in other chemical reactions in the past 5 years. To this end, state-of-the-art Density Functional Theory and Kinetic Monte Carlo frameworks will be employed to provide direct predictions of activity, selectivity, stability and yield for the most promising catalysts at relevant reaction conditions. Moreover, the large amount of results gathered from this project will serve as a big dataset to conduct descriptor analysis, and will suggest key properties that correlate well with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Enhancement of research competitiveness in molecular imagingat the Ernst Moritz Arndt University of Greifswald'.

assistant: **Concept**

Molecular Imaging is one of the fastest growing areas in basic and applied scientific research. It allows completely novel insights into basic cellular processes and thus creates the potential to better understand crucial pathophysiological mechanisms of diseases and to delineate effective diagnostic and therapeutic methods. The Ernst Moritz Arndt University (EMAUG) set up the Baltic MR Imaging Center in 2004. It employs more than 50 biologists and physicians working on current applications of magnetic resonance imaging in biology and medicine. However it is becoming increasingly clear that in order to comprehend life processes both under normal and pathologic conditions on the basic level, dynamic molecular imaging is required. So far, the infrastructure and expertise of dynamic molecular imaging is underdeveloped in Greifswald. The EMAUG is located in a convergence region, and the paucity of advanced equipment for research, the lack of a critical mass of experienced researchers, a reduced level of experience and knowledge of researchers as well as fewer international collaborations with highly competitive groups put severe limitations on our capacity to attract research funds from EU programs. Therefore the major objective of this proposal is to redress this balance by (1) stimulating the realization of the full research potential of our Medical Faculty by acquisition of high-tech equipment including a two-photon microscope; (2) achievement of a critical mass of skilled researchers by recruitment of eight experienced researchers; (3) improving S&T experience and knowledge of researchers by exchange of know-how and experience with scientific experts from eight Strategic Partners; (4) organization of workshops on molecular imaging; (5) dissemination and promotional acti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Winning Applications of nanoTEchnology for Resolutive hydropurification' (WATER).

assistant: **Innovation**

The overall objectives are: strengthening the research potential of the applicant in order to formulate a solid and long term research strategy about nanotechnology applications; increase its visibility in the ERA; determining an impact on the local economy and society through technology innovation. The focus is on the application of nanotechnology to water treatment, aiming to boost the research potential in this emerging research domain.Worldwide 1.2 billion people suffer inadequate access to clean water. Nanotechnology is expected to improve the water filtration with lower cost and energy. These are the major motivations for undertaking such an initiative – relying on the local know-how on nanotechnology – that aims to develop novel applications attracting industrial and service assets.The action includes widening of the existing research infrastructures; exchange of know-how and personnel with partners to tackle the issues of the proposed nanotech-based innovation and improve the opportunities of collaborative research; reinforcement of research staff; refinement of management capacities; innovative dissemination actions both for specialists and broader audience; development of a strategic plan for the IP. The multidisciplinary partnership includes top class scientists from UK, Spain, France, Germany and Norway, local authorities, representatives of ministerial institutions, water treatment SME and filters technology world leader company, to guarantee the effectiveness and sustainability of the Action.The nanotech filtration up-scalable to industrial production will sustain the society and the economy of the Ionic Sicily, by improving the quality of the sea water, through innovative filtration of waste water flowing into the sea, and of drinkable water in a region s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Competitive Wave Energy on Islands' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Wavepiston is developed on the shoulders of the first-generation wave energy technologies. Due to its low weight, low-tech design, simple installation and operations & maintenance, Wavepiston will be the disruptive technology that can make wave energy competitive with the other renewable energy sources.Our prototype test and Phase 1 feasibility study have confirmed this potential. The Wavepiston system is easy to assemble on site by local staff and can be deployed from a regular tug boat, just like operations and maintenance can be carried out without expensive specialists.In the Phase 2 project we will install a full-scale Wavepiston demonstration system to demonstrate the energy potential, durability and survivability ensuring a low cost per kWh.In the first step our customer focus is islands and isolated coastal communities. We already have the first 4 commercial customers in the pipeline; Isola Piana at Sardinia, Ebeye at Marshall Islands, Siargao at the Philippines and the Alidhoo J-resort at the Maldives. During Phase 2 we will prepare the first commercial projects together with professional energy project developers. This will enable us to start the commercialisation right after the finalisation of Phase 2.The Wavepiston technology is protected by several patents.The Phase 2 project plan has 6 work packages; WP1 Management, WP2 Preparation for the full scale demonstration, WP3 Manufacturing demonstration system and site installation, WP4 Demonstration and qualification, WP5 Business plan, commercial exploitation and dissemination WP6 NEC Requirements


**Keywords:** Wave Energy, Wave Power, Decarbonising Islands
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'All-solid-state quantum electrodynamics in photonic crystals'.

assistant: **Concept**

In quantum electrodynamics a range of fundamental processes are driven by omnipresent vacuum fluctuations. Photonic crystals can control vacuum fluctuations and thereby the fundamental interaction between light and matter. We will conduct experiments on quantum dots in photonic crystals and observe novel quantum electrodynamics effects including fractional decay and the modified Lamb shift. Furthermore, photonic crystals will be explored for shielding sensitive quantum-superposition states against decoherence.Defects in photonic crystals allow novel functionalities enabling nanocavities and waveguides. We will use the tight confinement of light in a nanocavity to entangle a quantum dot and a photon, and explore the scalability. Controlled ways of generating scalable and robust quantum entanglement is the essential  missing link  limiting quantum communication and quantum computing. A single quantum dot coupled to a slowly propagating mode in a photonic crystal waveguide will be used to induce large nonlinearities at the few-photon level.Finally we will explore a novel route to enhanced light-matter interaction employing controlled disorder in photonic crystals. In disordered media multiple scattering of light takes place and can lead to the formation of Anderson-localized modes. We will explore cavity quantum electrodynamics in Anderson-localized random cavities considering disorder a resource and not a nuisance, which is the traditional view.The main focus of the project will be on optical experiments, but fabrication of photonic crystals and detailed theory will be carried out as well. Several of the proposed experiments will constitute milestones in quantum optics and may pave the way for all-solid-state quantum communication with quantum dots in photonic crystals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Doppler Linear Processing for vascular Hydraulics and Imagery New S ystem'.

assistant: **Objectives**

EN Doppler linear Processing for Hydraulics Imagery New System1 OBJECTIVESCerebrovascular disease is a major source of stroke and death consecutive to the reduction of cerebral blood flow by artery stenosis or thrombosis, embolization of plaques and clots, intracranial haemorrage and hypertension. Most of these sources of stroke can be treated by medical or surgical means when detected early. For instance, it is of major importance in terms of public health and cost benefit to be able to evaluate by non invasive approach the potential risk of atheromateous plaques in the arteries supplying the brain as they are at the origin of a large number of strokes. Ultrasonic techniques (Bmode, Doppler) are more and more widely used for the early diagnosis and for the follow-up of cerebral vascular disease originating in the arteries of the neck (carotid and vertebral arteries), and detection of micro emboli in intracranial vessels by transcranial Doppler. Several very experienced tearns have shown that it was possible to refer patients to carotid surgery without X Rays angiography, only on the basis of ultrasonic examination. It becomes therefore necessary to evaluate very precisely the potential of ultrasonic techniques for the diagnosis, prognosis and follow-up of carolid disease, and to develop retrievable diagnostic procedures in order to reduce as much as possible the sonographer dependance of the ultrasonic examination. Three major objectives have been identified for the Dolphins project:1. to determine the most relevant haemodynamic and flow velocity parameters characterizing the degree of carotid stenosis, based on Doppler flow velocity measurements (continuous wave Doppler, pulsed wave Doppler, color coded Doppler including amplitude and frequency detection, Doppler enha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Suppression Of underwater Noise Induced by Cavitation' in the context of a Seventh Framework call.

assistant: **Objectives**

The aim of the SONIC project is to develop tools to investigate and mitigate the effects of underwater noise generated by shipping, both in terms of the footprint of an individual ship (a “noise footprint”) and of the spatial distribution of sound from a large number of ships contribution to the sound (a “noise map”). The project`s first objective is to enhance the understanding of noise generated by a cavitating ship propeller. The second objective is to validate predictions of noise levels for individual ships, and to classify ships based on simplified noise models. SONIC’s third objective is to map the noise generated by shipping in general and to propose mitigation measures for quietening the oceans.From studies in marine biology it is known that the behaviour of large sea mammals as well as fish can be influenced by background noise. Cavitation of ship propellers has been identified as a main source of this background noise. The EU requires Member States to demonstrate that levels of underwater noise do not harm marine life. It is believed that cavitation noise from shipping traffic is largely responsible for low frequency ambient noise,a need has arisen for an improved understanding of the correlation between cavitation and background noise in the seas.The EU has set out on improving the environment within its member states by adopting the Good Environmental Status. This has been further defined in the Marine Strategy Framework Directive, in which it describes descriptors for measuring the environmental status. One of these descriptors is the underwater noise linked to among others maritime transport. It is stated that the reduction of underwater noise will be a measure for the improvement of the environment. SONIC will deliver the technical knowledge required for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Networked Enterprise transFormation and resource management in Future internet enabled Innovation CloudS' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The objective of NEFFICS is to provide a new software platform as a basis for a new innovation driven ecology for networked enterprises, extended on top of an established cloud-based, software-as-a-service business operation platform, combined with an advanced innovation management software platform. The business context and value of the new platform will be demonstrated and validated in enterprise communities in two major European industrial sectors, through optimising their operational performance and innovation capacity. Open Business Model Innovation and process/service/product innovation will be managed and measured to demonstrate value generation at the business level.<br/>The work in NEFFICS will be driven by the needs of two user communities: Virtual Factory Network through Vlastuin, and Liquid Hospital through the Hospital of Sant Joan de Déu. Additional communities will be involved. Methodology and model support will be provided for Business Value Analysis Models from IC Focus, Networked Innovation Models from ICI of Aalborg University, and Enterprise Process and Service Models from SINTEF. Two European software companies, Cordys and Induct, provide respectively the cloud-based business operations and SaaS-based innovation community platforms. Their current offerings will be enhanced and integrated with other NEFFICS results to support, on a massive scale, enterprise transformation to innovative value networks.<br/>The project will be actively involved in establishing international standards from OMG in the areas of value analysis models, business service/process models, and knowledge process/case management models; and European standards from the new European CEN TC389 on innovation management, ensuring their suitability for networked enterprises.<br/>The con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The compilation of a second generation ‘web-based’ ornithological atlas for Kenya' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Kenya’s avifauna is one of the better studied in Africa, second probably only to South Africa. Despite this, and whilst there are many bird watchers active in Kenya and thousands of tourists visit Kenya specifically for ornithological safaris, we still know very little about changes that have occurred in species’ distribution and status over the past 25-50 years. Range extensions and contractions have been noted but only from ad hoc observations. While records of birds found in Kenya are very much up to date, a real gap exists in our understanding of avian distributions and the contribution of changing global climate on observed species distribution patterns.Over a timeline of 2 years based at the Natural History Museum of Denmark, during which the applicant will initiate the project and receive thorough training in the techniques required to achieve the project, followed by a third year return to the National Museums of Kenya, where the applicant will transfer these techniques to local parties who will be vital to the continual expansion of the project, this proposed project will provide the applicant with the required training to enable him to take community based observational data, and use it in order to deliver a demand driven, continually evolving web-based bird atlas for Kenya. In addition to mapping the current avian diversity, the atlas will contain climate-based species niche modelling and genetic data, in order to provide a comprehensive view of the avifauna and its future prospects. This will consolidate the position of the host institute as one of the most innovative Natural History Museums in the world, in particular with regards to moving away from standard ‘collecting’ to innovative new ways of bringing natural history to the public.