RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Delivering Better Starting Points for Drug Discovery: New Compound Libraries Driven By Intelligent Design' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Whilst the need to generate new therapeutics has never been more important, drug discovery is at the same time becoming much more difficult. In short, we need to be more efficient at developing drugs. One way of achieving this is to reduce the attrition rates, which currently blight the drug-discovery process, by populating compound screening libraries with more structurally diverse and higher quality, i.e. designed, molecules to provide better starting points for drug development. Pharma also needs a new type of researcher given an increasing proportion of scientists are now finding employment in smaller companies, where they need to be more flexible, entrepreneurial and business-aware. iDESIGN seeks to address these key challenges by combining the complementary expertise from both academic and industrial sectors. iDESIGN has the following Principal Objectives: 1) to use the ESRs' individual research projects to develop new, structurally diverse, 'smart' compound libraries for the sector to use in hit-identification screening campaigns; 2) to provide a training programme which will see the ESRs becoming expert synthetic and medicinal chemists, confident research scientists, consummate professionals, effective communicators and innovators with a creative and entrepreneurial spirit. iDESIGN will begin with an academic training phase, during which the ESRs will undertake project-wide training whilst acquiring the synthesis skills to generate bespoke molecular scaffolds, which they will elaborate and validate using in silico and experimental methods. The ESRs will then transfer to one of the industrial partners to take full advantage of their Industrial Supervisors' expertise and the available instrumentation to complete the library-generation aspect of their research proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Functions and mechanism of active DNA demethylation' (DNADEMETHYLASE) under Seventh Framework.

assistant: **Objectives**

Epigenetic gene regulation is of central importance for development and disease. Despite dramatic progress in epigenetics during the past decade, DNA demethylation remains one of the last big frontiers and very little is known about it. DNA demethylation is a widespread phenomenon and occurs in plants as well as in animals, during development, in the adult, and during somatic cell reprogramming of pluripotency genes. The molecular identity of the DNA demethylase in animal cells remained unresolved and has hampered progress in the field for decades. In 2007 we published that Growth Arrest and DNA Damage 45 a (Gadd45a) is a key player in active DNA demethylation, which opened new avenues in the study of this elusive process. The goal of this project is to further analyze the mechanism of DNA demethylation as well as the role played by Gadd45 in development. Given the many unresolved questions in this burgeoning field, our work promises to be ground-breaking and therefore have a profound impact in unraveling one of the least understood processes of gene regulation. Specifically we will address the following points. I) The biological role of Gadd45 mediated DNA demethylation in mouse embryos and adults is unknown. We have obtained mouse mutants for Gadd45a,b, and g and we will analyze them for developmental defects and dissect the methylation regulation of relevant genes. II) The targeting mechanism by which Gadd45 is binding to and demethylating specific sites in the genome is a central unresolved issue. We have identified a candidate DNA binding protein interacting with Gadd45 and we will analyze its role in site specific targeting of DNA demethylation in vitro and in mouse. III) We found that Gadd45 is an RNA binding protein and we will therefore analyze how non-coding R
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Epistasis analysis of angiogenes with high cellular definition' (AngioGenesHD), addressing dissemination and exploitation.

assistant: **Impact**

Blood and lymphatic vessels have been the subject of intense investigation due to their important role in cancer development and in cardiovascular diseases. The significant advance in the methods used to modify and analyse gene function have allowed us to obtain a much better understanding of the molecular mechanisms involved in the regulation of the biology of blood vessels. However, there are two key aspects that significantly diminish our capacity to understand the function of gene networks and their intersections in vivo. One is the long time that is usually required to generate a given double mutant vertebrate tissue, and the other is the lack of single-cell genetic and phenotypic resolution. We have recently performed an in vivo comparative transcriptome analysis of highly angiogenic endothelial cells experiencing different VEGF and Notch signalling levels. These are two of the most important molecular mechanisms required for the adequate differentiation, proliferation and sprouting of endothelial cells. Using the information generated from this analysis, the overall aim of the proposed project is to characterize the vascular function of some of the previously identified genes and determine how they functionally interact with these two signalling pathways. We propose to use novel inducible genetic tools that will allow us to generate a spatially and temporally regulated fluorescent cell mosaic matrix for quantitative analysis. This will enable us to analyse with unprecedented speed and resolution the function of several different genes simultaneously, during vascular development, homeostasis or associated diseases. Understanding the genetic epistatic interactions that control the differentiation and behaviour of endothelial cells, in different contexts, and with h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Environmental exposures and lymphoid neoplasms' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Lymphoid neoplasms are the fifth most frequent neoplasm in the European Union and their incidence is steadily increasing. They therefore represent a considerable and increasing health burden. The proposed study will recruit over 3500 cases of lymphoid neoplasms and a group of comparable controls in 8 centres of the European Union. This study will test specific hypotheses concerning whether changes in our physical, occupational and human environment are related to the incidence of lymphoid neoplasm's. These include sunlight exposure, pesticides, solvents and previous medical history. It will conduct a more detailed assessment of environmental exposures than previously achieved. It will also provide accurate information on subtypes of lymphoid neoplasm's allowing for an effective analysis of risk by diagnostic categories.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Towards unravelling self-assembly/disassembly mechanisms of photo-switchable supramolecular gels by super-resolution microscopy and their use for drug crystallization' (LIGHTSUPGEL).

assistant: **Concept**

The overarching scientific goal of the LIGHTSUPGEL study is to design and synthetize novel reversible photo-switchable azobenzene and bis(urea)-based supramolecular gels, and to develop a super-resolution microscopy-based methodology to visualize the self-assembly and disassembly process in real-time with the aim of unravelling their underlying mechanisms. The cutting-edge combination of super-resolution STED and FLIM microscopies, together with environment-sensitive fluorescent probes, will be employed to spatially controlled photo-switch the gelation and de-gelation, and for first time, simultaneously monitor the process with nanoscopic resolution. Furthermore, the application of this new knowledge and novel photo-switchable gels in gel-mediated drug crystallization, will be explored. The possibility of light-triggered drug crystal harvesting photo-switchable gels offers, will be the first ever described non-invasive and reversible method to harvest crystals from gels. This new technology will mean a huge advance in the field of gel-phase drug crystallization, bringing it closer to its industrialization. By completing this ambitious multidisciplinary work, the applicant will be in an excellent position to create cross-disciplinary collaborations with research groups and industry across Europe and to becoming an independent researcher himself.


**Keywords:** supramolecular gels,  super-resolution microscopy,  photo-switchable gels,  STED,  FLIM,  drug crystallization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Informational Citizenship: Toward a Global Ethnography of Practices and Infrastructures of Datafication in the Global South' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Data has been extolled as the new frontier of development. Whereas western elite actors have contested big data for its flattening of social life and information extraction, grassroots initiatives have been championing big data to promote citizen rights, improve state accountability, and reduce inequality.InfoCitizen will:(1)study the citizenship practices and technologies coalescing around model initiatives to produce and circulate data in the Global South. We contend that for favela residents in Brazil, ethnic minorities in Portugal and Germany, and poor citizens in Tanzania and Kenya, far from splintering and prying, data has the potential to promote cultural change, political identity, and economic wellbeing via better, faster, and more reliable public and private statistics.(2)blend insights from the social studies of quantification, the anthropology of data, and citizenship studies to grasp data produced by experts and citizens across top-down and bottom-up data ecosystems. Via the concept of informational citizenship, we will illuminate the politics (infrastructures, epistemologies, visibilities) and poetics (experiences, socialities, and affects) of datafication, their impacts on law- and policymaking, and their effects on individuals, communities, and institutions in Brazil, Portugal, Germany, Tanzania, and Kenya.(3)combine archival, digital, audiovisual, and quanti-qualitative methods to unpack the toolscensuses, smartphones, policy reportsand actorsNGOs, data labs, legal commissionscrystallizing in the wake of grassroots numbers. We propose a global and comparative ethnography of datafied subjectivities and their interplay with transnational networks of expertisesuch as think tanks, governments, and businesses.(4)generate applied and analytical research and a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Probing new physics with four top quarks' (4TopAndMore).

assistant: **Innovation**

At the Large Hadron Collider (LHC), protons are collided at the highest possible energy to generate subatomic elementary particles. We use the results of these collisions to understand our universe at the most fundamental level. Many theorists believe that new physics exists at a very high energy. The top quark is the heaviest elementary particle known to date with unique properties. It is therefore naturally suspected to have hidden connections with new physics.The simultaneous production of four top-quarks (tttt) is the most energetic process accessible with the LHC, making it a unique place to search for heavy new physics, which are less likely to appear elsewhere. The first evidence of these extremely rare events was only revealed last year, and we know very little about them. With the world-record energy at LHC Run3 (13.6 TeV), we expect 20% higher tttt events production rate. This offers a timely opportunity to further study this process.With an aim to find new physics, we will study tttt events in unprecedented detail with the ATLAS experiment at the LHC. We will measure the inclusive production rate and the kinematic properties of these events. We will use the measured results to probe new physics, with unique approaches that do not rely on new physics predictions made upon specific assumptions (which could be wrong). The results have the potential to reveal new physics that are too energetic and beyond the reach of the LHC. This will be the first time this is done for tttt events. The measured tttt event kinematics will be corrected to remove effects from the detector resolution and acceptance. This allows theorists to directly test their new physics predictions against the experimental results, continuously generating impact in the relevant scientific communit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Minority civil society, inter-ethnic peace and sustainable democracy' (MINSOC), addressing dissemination and exploitation.

assistant: **Impact**

Minority civil society, inter-ethnic peace and sustainable democracyEthnic minorities make up a significant part of societies around the world, and contemporary migration patterns indicate that ethnic diversity is increasing globally. Meanwhile, state-driven majoritarian nationalism has strengthened in many regions of the world, including new and long-established democracies. In recent years, an increasing number of governments have used majoritarian nationalism to regain or construct legitimacy, following a familiar script: blaming internal and external ""others"" for economic and social issues. Comparative evidence reveals that members of ethnic, racial, or religious minorities are more likely than majority members to become alienated from democratic institutions.  There is an urgent need for the scholarly community to find useful answers to the question of how democracy and inter-ethnic peace can be maintained under such conditions.There is a rich body of scholarship about governmental strategies and policies aimed at achieving minority integration. There is, however, a dearth of comparative research on the role of social institutions, and particularly on the role of minority social institutions, in shaping state-minority relations, despite broad consensus on the significance of social institutions (such as churches, schools, cultural associations, etc.) in ethno-cultural boundary-making. This research begins to fill that gap by creating a comparative index of minority civil society institutions that minority populations use for ethnic boundary-making, based on the patterns observable among ten minority populations in post-communist Europe.  The research will also identify those combinations of minority civil society institutions that are most likely to provide resou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Labour Market Integration: Consequences of Cross-Border Commuting' (BRIDGE), addressing dissemination and exploitation.

assistant: **Impact**

Free movement of people and a common labour market is one of the four main pillars underlining the single market of the EU. The central aim of the Europe 2020 strategy, is to promote “smart, sustainable an inclusive growth”. One of the flagship initiatives of the EU2020 strategy centers on the labour market with of focus on the labour market matching, e.g. through labour mobility. In 2016 around 92% of the EU-28 workforce resided and worked in the same region (NUTS 2), 7% commuted between regions while just under 1% of the workers were cross-border commuters. These low mobility figures are striking considering that over a third of the EU population lives in a border region. Hence, the potential for increased integration across borders is large but there is a gap in the knowledge on mobility through cross-border commuting.In the past, data constraints have hindered research on cross-border commuters, but in the proposed project, BRIDGE, I am able to overcome those challenges. BRIDGE is at the forefront of this research by being the first study to merge and link employee-employer micro-data across borders. In addition thereto, we have the unique opportunity to look simultaneously at the impact of a large policy shock (Öresund Bridge) on labour market and firm outcomes in both Denmark and Sweden before and after the introduction of a physical connection  between the two countries.This combination of a large policy shock and cross-country linked micro-data allows for a large array of potential research questions related to labour market and firm outcomes, integration, and regional development. The focus of BRIDGE will be on how lower cross-border thresholds to labour mobility impacts economic outcomes of the commuter and the employers/firms hiring them. In particular: Does
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Direct simulation studies of flame stabilization processes - ii' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The project is part of a large scale research program initiated to stud combustion problems using direct numerical simulation (DNS).  The present project will focus on the flame stabilization problem. This question IS of fundamental interest and it is also of technical importance in the design of gaseous. Liquid fuel (turbo-jet engines) or solid fuel (pulverized coal) combustion.  We propose to study a simplified flow pattern (triple layer: 3 coflowin streams of fuel. oxidizer and hot combustion products) representative of the typical flow structure prevailing in the stabilisation regions of many combustion devices used in industrial applications (continuous burners for boilers and furnaces).  Our objective is to identify the parameters governing the flame ignitio and stabilization. DNS offers very detailed description of the flame zone and is therefore a perfectly-well suited tool to investigate flame characteristics. It is planned to derive a simplified model based on DNS analysis and basic physical considerations. At last, we are interested in transferring our results to our industrial partners (implementation of the model into an engineering combustion code).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Dark Higgs Hunting at the Large Hadron Collider'.

assistant: **Innovation**

This project proposes a search for a novel signature of dark matter (DM) production at the Large Hadron Collider (LHC) resulting from the emission of an additional Higgs boson in the dark sector. The presence of such a dark Higgs boson is motivated both by the need to generate the masses of the particles in the dark sector and the possibility to relax constraints from the dark matter relic abundance. If the dark Higgs boson is the lightest state in the dark sector and has a small mixing with the Standard Model (SM) Higgs boson, it predominantly decays into b-quarks for a dark Higgs boson mass below 160 GeV. This gives a distinct mono-dark-Higgs signature to search for consisting of a two collimated b-jets in association with missing transverse momentum from a pair of undetected dark matter particles. The new search channel probes large parts of phase space which are inaccessible to conventional mono-jet and di-jet searches and is complementary to the existing dark matter search programme at the LHC. The potential discovery of a dark Higgs boson would provide a unique window to the dark sector with excellent opportunities for further exploration, e.g. by probing the couplings of the dark Higgs boson to other SM particles. The implications would even go beyond the question of DM as it would suggest that the Higgs mechanisms is more fundamental that what is currently believed. The project described here proposes to use the data collected with ATLAS at the LHC by the end of Run-2 to search for a dark Higgs boson decaying to b-quarks. In addition, the project has a hardware part on the upgrade of the ATLAS inner tracker (ITk) for High-Luminosity LHC. This is an important element for the preparations for future searches for the dark Higgs boson, either as a means to further e