RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for '3D Imaging Across Lengthscales: From Atoms to Grains' (3DIMAGE).

assistant: **Innovation**

Understanding structure-property relationships across lengthscales is key to the design of functional and structural materials and devices. Moreover, the complexity of modern devices extends to three dimensions and as such 3D characterization is required across those lengthscales to provide a complete understanding and enable improvement in the material’s physical and chemical behaviour. 3D imaging and analysis from the atomic scale through to granular microstructure is proposed through the development of electron tomography using (S)TEM, and ‘dual beam’ SEM-FIB, techniques offering complementary approaches to 3D imaging across lengthscales stretching over 5 orders of magnitude.We propose to extend tomography to include novel methods to determine atom positions in 3D with approaches incorporating new reconstruction algorithms, image processing  and complementary nano-diffraction techniques. At the nanoscale, true 3D nano-metrology of morphology and composition is a key objective of the project, minimizing reconstruction and visualization artefacts. Mapping strain and optical properties in 3D are ambitious and exciting challenges that will yield new information at the nanoscale. Using the SEM-FIB, 3D ‘mesoscale’ structures will be revealed: morphology, crystallography and composition can be mapped simultaneously, with ~5nm resolution and over volumes too large to tackle by (S)TEM and too small for most x-ray techniques. In parallel, we will apply 3D imaging to a wide variety of key materials including heterogeneous catalysts, aerospace alloys, biomaterials, photovoltaic materials, and novel semiconductors.We will collaborate with many departments in Cambridge and institutes worldwide. The personnel on the proposal will cover all aspects of the tomography proposed using h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Past Continental Climate Change: Temperatures from marine and lacustrine archives' (PACEMAKER).

assistant: **Innovation**

Global climate change is a topic of major interest as it has a large impact on human societies. Computer models used to predict directions of future climate change are validated by means of retrospective analysis of past climate changes. Detailed reconstruction of past climates, especially temperature, is, therefore, of considerable importance. Several tools (proxies) are available to reconstruct absolute sea surface temperatures. Continental temperature reconstructions, however, are hampered by a lack of quantitative temperature proxies and, consequently, are often qualitative rather than quantitative. Recently, my group discovered a new quantitative continental temperature proxy, the MBT index, which is based on the distribution of membrane lipids of soil bacteria. Their composition is a function of annual mean air temperature (MAT). These lipids are transported by rivers to the ocean and deposited in marine sediments. Determination of the MBT index in cores from river fans can, thus, potentially be used to reconstruct continental, river basin-integrated, temperatures from a marine record in front of large river outflows. We will study the mechanisms of transport of the soil bacterial membrane lipids to the ocean in many river systems and compare the down-core changes in their composition with conventional MAT proxies. We will also investigate the potential of lake sediments as archives of continental climate change using our new MBT palaeothermometer and apply this thermometer in the assessment of continental climate change during the transition from a hothouse to an icehouse Earth in the last 100 million years. This project that combines aspects of microbiology, molecular ecology, lipid biogeochemistry and paleoclimatology will bring this novel continental palaeothe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The impact of foreign accent on social interaction and cognitive processes.' (SocialAccent) under Horizon 2020.

assistant: **Objectives**

‘Ants don’t sleep’. One would think that this sentence should be assessed as equally true (or false) independently of the speaker’s accent. It is not the case. Overall, speakers with a foreign accent (FA) are judged as less trustworthy, less educated, less intelligent and less competent than native speakers. This negative bias towards foreign-accented speakers (thereafter, FA bias) has critical consequences on many aspects of everyday life (e.g., job discrimination). Given the migration flow in Europe, it is crucial to understand the impact FA bias has on social interaction. This negative bias seems to have different origins: linguistic (FA is more difficult to understand than native accent, thus, it reduces ‘processing fluency’), and social (FA triggers a rapid categorisation of the speaker as out-group). The project will investigate 1) how FA bias affects cognitive processes, and 2) the modulation of the FA bias by social stereotypes and its consequences in the brain. The project is innovative as it examines the real-time impact of FA on cognitive processes using event-related potentials, a technique that allows recording online brain activity. The proposed experiments involve native listeners and non-native speakers with a medium FA. The findings will be of interest for many fields like linguistics, social psychology, cognitive neuroscience, and to some extent for other social disciplines (law, education, health). They will also be relevant for social institutions (Council of Europe) and services for immigrants (Linguistic Integration of Adult Migrants). The outcome of the project will be useful to generate solutions to reduce this social bias. Moreover, the project fits well with the current interest of the ERA, being in line with FP7 funded projects like ‘European
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Valorisation of Monumental Heritage through Higher Education and Professional Training. Socio-economic study and analysis of National Policies on EU-MED-DEV countries and EC Directives' (TRAINMONHER) under Sixth Framework.

assistant: **Objectives**

According to the definition of a Conservation Scientist given in the Bologna Document 2000 A Conservation Scientist today can be defined as a scientist with a degree in one of the natural, physical and/or applied scientific disciplines and with further knowledge in conservation (ethics, history, cultural values, historical technologies, past and present conservation technologies and practice, specific scientific aspects, etc.), which enables him/her to contribute to the study and conservation of cultural heritage within an interdisciplinary team". Taking into account this definition and broadening it, including valorisation of monumental heritage and materials in cultural heritage, we can conclude that monumental heritage needs not only sciences and technology, but also humanities. Besides, social and economical aspects play an important role in the valorisation of monumental heritage process. It is a complex overall to implement it at university and professional/continuing education level. However, it is a necessity regarding conservation from an historical point of view, but also as potential resources and social development such as either cultural tourism or other industrial activities and services.Our SSA's aim is to design capacity building through educational and training programmes with interdisciplinary and transversal issues, which include a large part of knowledge declared in Bologna Document. The programme design will be set up through an interdisciplinary group composed of 8 partners. EU (Spain, Portugal and France), West Balkans (Croatia) and MED - DEV countries (Morocco, Argentina and Mexico). Regarding the last countries (MED and DEV) a pilot programme will be implemented with a selective process. Additionally our SSA will be completed in two ways: with a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'First automated risk management platform to enable safety, fairness, explainability, and continuous monitoring of generative AI systems' (QuantPi) under Horizon Europe.

assistant: **Objectives**

We target the global AI market, which has current value of 187.1B (TAM) and a CAGR of 37.3% until 2029. In this TAM, the generative AI market with 12.5B and 27% CAGR constitutes a sub-market addressed by us. AI risk management and governance sector (SAM) has a current market value of 220M and a CAGR of 42.1% until 2029. Industry leaders, e.g., Musk and Wozniak, request a stepping back from training models with an ever-increasing complexity. QuantPis platform is the first all-in-one, model-agnostic, plug & play solution for risk management of generative AI. For the first time, we enable companies developing or operating generative AI systems to automatically assess and mitigate major risks across dimensions such as performance, fairness, robustness, explainability, and more. Our solution assesses conformance with +100 standards and regulations, including the EU AI Act, ISO/IEC 23894, and NIST AI RMF and assists companies in their pursuit of responsible and trustworthy AI systems.


**Keywords:** Generative AI, Explainable AI, Responsible AI, Trustworthy AI, Safe AI, Fair AI, AI Bias, AI Ethics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Crystallographic studies of bacterial membrane transport systems' to be submitted under Sixth Framework.

assistant: **Abstract**

This project will study substrate translocation mechanisms of multi-component drug-efflux pumps that transport molecules across membranes in Gram-negative bacteria. These pumps serve both protective and virulence associated functions, by forming channels associated with the export of invasive proteins and the efflux of toxic compounds. At the same time, the outer membrane component of the pump, TolC, is a point of weakness for the bacterium since it is a receptor for bacteriophages and is a point of entry f or certain bactericidal proteins, known as colicins.The initial stages of the project will involve model building and refining of the crystal structure of a complex composed of TolC and a truncated form of the colicin E1. In parallel, crystallisation of t he complex between TolC and full-length colicin E1 protein will be pursued. These structures are expected to provide information on the protein translocation mechanisms.In a second aspect of the project, mutants will be engineered that trap and stabilize active transport assemblies from pathogenic species. We will use the available structural information to design covalent assemblies involving TolC-related proteins with other components of the transport machinery, including the AcrA family of membrane fusion proteins. One tool that we will develop in this study is a novel lipopeptide compound that will be implemented for solubilization of membrane protein complexes. These compounds will be tested for suitability for crystallisation of individual pump components as well as for mass-spectrometric analyses of the complete drug efflux pumps. These studies will give clues to the still enigmatic role of the fusion proteins in the formation of the drug efflux channels. Apart from fundamental knowledge, the results from thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Comedy of Political Philosophy.  Democratic Citizenship, Political Judgment, and Ideals in Political Practice.' under Horizon 2020.

assistant: **Concept**

Despite the rich history and contemporary relevance of the intersection of comedy, political practices, and political thought, comedy has thus far not received sustained attention in the field of political philosophy. This research programme will address this lacuna by developing parallels between (i) the specific outlook on human action offered by comedies and (ii) the perspective of a tradition of political thought known as political realism.The overall objective of this research programme is to demonstrate that comedy reflects the theoretical and methodological commitments of political realism, and to establish comedy’s contribution to realism by drawing out realism’s transformative potential. Three specific research objectives will be combined to support the overall objective. (a) The first objective will develop an account of democratic citizenship informed by comedy by exploring Aristophanes’ comedies. (b) The second objective will develop an account of political judgment informed by comedy, by analysing Machiavelli’s comedies and political writings in relation to each other. (c) The third objective will develop an account of the relation between ideals and practice in politics informed by comedy by drawing on theoretical reflections on comedy by Hegel, Vischer, and Marx. Each of the specific research objectives corresponds to a central feature of political realism. By developing these objectives through comedy, the researcher will explicate structural parallels between comedy and political realism. In each of the specific objectives, the transformative potential inherent in comedy will be elucidated. In doing so, the researcher will use insights derived from this parallel to develop a more nuanced understanding of political realism’s potential to conceptualize so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ex vivo assessment of therapy for brain tumors' in the context of a Sixth Framework call.

assistant: **Objectives**

CAPSANT Neurotechnologies is an emerging SME that spun out from the University of Southampton (UK). The scientific and technological basis of the company, that makes its originality and strength on the market, is its unique ability to screen drugs in a fully relevant ex vivo set up.In this set up, experimental models of-up to now- stroke or epilepsy can be analysed in brain slices maintained in organotypic cultures, and outcome measures of neuronal alteration and death provide quantified clues about the protective effects of pharmacological compounds.This platform is currently used for high throughput screening by several industrial partners of CAPSANT Neurotechnologies. Independently, the academic team led by Dr Marc Peschanski at INSERM in Creteil, France, has developed in recent years an experimental model based upon an adaptation of the same methodology, that allows analysing potential therapeutics for an additional brain disease, namely glioblastoma.In addition to allowing proliferation and intra-parenchymal migration of tumour cells to be quantified, this technique (called ISIS for intra-slice implantation system) has revealed instrumental to study tumour-induced angiogenesis. Several molecules endowed with anti-tumoral or anti-angiogenic potentials have already been successfully screened in this set up.The program proposed for this Marie-Curie fellowship directly stems from the obvious complementarity of the two R and D programs. Collaboration, in particular through extended periods of work by Marc Peschanski and members of his team at CAPSANT, will allow the transfer of technology to the company, extending its offer to industrial partners to screening for therapies applicable to brain tumours.Conversely, CAPSANT scientists will provide high level training to Mar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Parameterized Approximation' (PARAPPROX).

assistant: **Innovation**

The main goal of this project is to lay the foundations of  a ``non-polynomial time theory of approximation"" -- the  Parameterized Approximation  for  NP-hard optimization problems.   A combination that will use the salient features  of  Approximation Algorithms andParameterized Complexity. In the former, one relaxes the requirement of finding an optimum solution. In the latter, one relaxes the requirement of  finishing in polynomial time by restricting thecombinatorial explosion in the running time to a parameter that for reasonable inputs is much smaller than the input size. This project will explore the following fundamental question:Approximation Algorithms + Parameterized Complexity=?New techniques  will be developed that will simultaneously utilize the notions of relaxed time complexity and accuracy and thereby make problems for which both these approaches have failed  independently, tractable. It is however conceivable  that for some problems even this combined approach may not succeed. But in those situations we will glean valuable insight into the reasons  for failure.  In parallel to algorithmic studies,  an intractability theory  will bedeveloped which will provide the theoretical framework to specify the extent to which this approach might work.  Thus,  on one hand the project will give rise to  algorithms that will have impact beyond the boundaries of computer science and on the other  hand it will lead to a complexity theory that will go beyond the established  notions of intractability.  Both these aspects of my project  are groundbreaking -- the new theory will transcend our current ideas ofefficient approximation and thereby raise the state of the art  to a new level.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced 3D in vitro models based on magnetically-driven docking of modular microscaffolds' under Horizon Europe.

assistant: **Concept**

This project is focused on the design, the production, the characterization, and the proposal for future commercialization of 3D modular co-culture systems, specifically designed to recapitulate the physio-pathological microenvironment of brain tumor. The key technology at the base of the proposed project is the design of magnetic microscaffolds and their fabrication through two-photon polymerization (2pp), a disruptive mesoscale manufacturing technique that enables low-cost obtainment of microstructures with nanometric resolution, characterized by unprecedented levels of accuracy and reproducibility. A microtubular structure scaffolding endothelial cells and connected to a fluidic system will be exploited to mimic the blood-brain barrier: this biohybrid device will be the base for the assembly of ferromagnetic “microcages” hosting glioblastoma cells, and will be provided with docking systems for superparamagnetic “microcages” carrying undifferentiated and differentiated neuronal progenitor cells. This approach represents a disruptive innovation with respect to other 3D models available in the literature, as it will allow a faithful recapitulation of the complex glioblastoma microenvironment through a platform that can be very easily handled in any laboratory. High-throughput screenings of brain drugs and in vitro testing of the efficacy of different anticancer therapies are envisaged upon successful accomplishment of the project, leading to a pioneering generation of flexible multi-cellular platforms easily adaptable to the mimicry of different pathological conditions.