RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Heritage Language Acquisition: The qualitative nature of input and cross-linguistic influence'.

assistant: **Concept**

This project aims to fill important gaps in our existing knowledge of Heritage Language (HL) acquisition, a subfield of bilingualism studies. While most previous research has focused on describing how HLs diverge from their monolingual baselines, the main objective of HeLA is to understand why heritage grammars develop the way they do. To this end, we focus on the severely understudied population of pre-teenage heritage speakers (HSs) of Spanish. While much attention has been paid to the role of input quantity in HL acquisition, relatively little is known about the qualitative nature of that input. This project investigates input quality by focusing on cross-generational attrition: the situation where HSs’ parents might exhibit changes in their L1 use –due to prolonged exposure to a second language and lack of activation in their first language– which get passed on to the next generation of HSs. We will approach this topic in a unique and novel way, namely by including individual analyses of children and their respective parents, and establishing a one-to-one connection between the two. Thus far, the majority of research on heritage Spanish, has been carried out in the context of the US. HeLA offers a valuable contribution to the field by comparing Spanish in two different linguistic contexts in Europe: the UK and The Netherlands. By looking at phenomena that are instantiated differently in English and Dutch –grammatical gender and subject expression– we will gain more insight into the role of cross-linguistic influence from the majority language. We furthermore combine behavioural and online measures of competence to examine whether the type of task brings anything to bear on the participants’ performances. Gaining a deep understanding of the factors that shape heritag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Pulse-plasma technology and equipment for formation of high-alloyed microcrystalline layers on metal working surfaces of tools and machine parts'.

assistant: **Innovation**

Current technologies for treatments on metal working surfaces of tools and machine parts typically involve problems at critical areas. For example, process efficiencies are low, end-product performance characteristics are far from optimal, costs for materials, machining and heat treatment are high, and not versatile for different kinds of alloys. As a result of this product prices are high, processes are inefficient, product quality levels have variations and product performance is not state-of-the-art leading to damages, losses and inefficiencies in end-use situations. This project is proposed to research and develop technologies and equipment based on pulse wise plasma layer modifying for metal working tools and machine parts. This system should fulfil the essential requirements for typical applications of these materials in a wide range of industries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Pyrophosphate Surrogates with Low polarity as part of glycosyltransferase ligands' under Horizon 2020.

assistant: **Concept**

PyroSuL (Pyrophosphate Surrogates with Low polarity as part of glycosyltransferase ligands) is a project focused on the development of synthetic building blocks acting as surrogates for the pyrophosphate moiety in glycosyltransferase inhibitors. The final aim of this project is obtaining less polar ligands and inhibitors able to permeate across cellular membranes, which is the bottleneck for these inhibitors to have in vivo biological application. Through structure-based design, new surrogates will be explored. Interaction studies will be carried out through firstly computational approaches, and spectroscopic (nuclear magnetic resonance) and spectrometric (mass spectrometry) techniques will be employed. Surrogates showing promising affinity with the pyrophosphate recognition zone will be synthetically incorporated to substrate-like compounds, bearing a nucleoside and a carbohydrate or mimic. Final derivatives are supposed to show good protein affinities and membrane permeability properties.


**Keywords:** glycosyltransferase, inhibitors, pyrophosphate, surrogates, NMR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Representations, Motives and Langlands Duality'.

assistant: **Objectives**

Numerous advances impacting society, from basic science to consumer technology, are built on fundamental research in mathematics. Examples include non-Euclidean geometry (leading to general relativity, and then GPS navigation); number theory (leading to public-key cryptography, and then to secure online commerce); and topology (with applications in image recognition and medical diagnostics).This doctoral network, ReMoLD: Representations, Motives and Langlands Duality, will advance fundamental research in three highly active fields of mathematics: representation theory, algebraic geometry and number theory. Specifically, ReMoLD is at the forefront of research in geometric representation theory and the Langlands program using recent mathematical innovations from the field of motives.ReMoLD will build a European network of doctoral candidates that excels in fundamental research in mathematics, implements innovative training formats and partners with a leading European quantum computing company, in order to form a group of scientists ready to apply to highly competitive positions in academia and industry.


**Keywords:** Representation theory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'EUROPEAN MISCANTHUS IMPROVEMENT: BROADENING THE GENETIC BASE, TESTING GENOTYPES AND DEVELOPMENT OF BREEDING METHODS' (EMI).

assistant: **Innovation**

Miscanthus is a perennial high yielding grass from East Asia. It is an environmentally benign plant with a lot of using alternatives. One of the most promising are the use fibre plant or for combustion. Several experiments with Miscanthus 'Giganteus', a sterile hybrid, showed a good potential of this plant in Europe but also showed a lot of problems like unsufficient winter survivaland a low adaption to most ecological regions of Europe. All these experiments have been done with one single clone and there is nogenetical variability available in Europe that could be used to overcome these problems. But there is a vast genetic variability in the East Asian region, the origin of Miscanthus. A lot of Miscanthus germplasm has been collected by some of the project partner in China and Japane.Objective of this project is to provide germplasm to broaden the genetic base of Miscanthus in Europe and to provide breeding techniques for Miscanthus. So all European regions can be supplied with varieties that can: - satisfy the demands of different ecological regions in Europe, - fulfill the quality standards set for specific industrial uses, and - reduce the risk of widespread occurrence of pests and diseases.These objectives will be attained by: 1. testing different genotypes in field tests in different climatical regions and analysing their fibre and combustion quality:- to determine the clonal adaptability to ecological conditions,- to determine the influence of climate an yield and quality (combustion and fibre quality) of the biomass,- to determine the influence of the genotype on yield, quality and winter survival,- to determine the environment-genotype interactions, and- to be able to predict what genotype is suitable for any given ecological zone in Europe.2. developing breed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'International collaborative study of cancer risk among radiation workers in the nuclear industry' (LOWDOSERISK).

assistant: **Innovation**

Radiation protection standards are mainly based on the follow-up of atomic bomb survivors and medically irradiated persons. The use of these data to predict cancer risk from protracted low doses involves uncertain extrapolations. Occupational cohort studies, such as the International Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry, have the potential to provide a direct assessment of these effects. This study covers over 500,000 individually monitored workers from 14 countries (10 from Europe, 7 from the EU). Data collection is virtually complete in most countries. Funds are requested for the international analyses, including comparisons with high dose studies and application of methods to improve the estimates of risk. These consist of models to take into account heterogeneity of risk across cohorts and errors in dose estimates, as well as biologically based models for the estimation of cancer risk.The main objective of the International Study is to obtain precise, direct estimates of radiation-induced cancer risk following protracted low doses of ionising radiation. The specific purpose of the study is to provide data for comparison with the risk estimates derived from studies of persons having received high dose/high dose-rate exposures. This will provide a direct test of the adequacy of the extrapolation models used currently for radiation risk assessment and for the setting of radiation protection standards, and may assist in the construction of improved risk assessment models.The main objectives of the current proposal are: to carry out the international combined analyses of data from the national studies; to carry out formal comparisons improve the estimates of radiation-induced cancer risk.Current protection standards for envir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ALBATROSS: The most energy efficient flying bird' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Mobility and transportation are at the heart of our society which facilitate access to jobs, goods and services. And because air travel is one of the fastest and most progressive branches of the transportation sector it is also exposed to large visibility and strong European and worldwide pressure on sustainability. ALBATROSS is a wide scale initiative of major European aviation stakeholder groups to demonstrate how the technical and operational R&D achievements of the past years can transform the current fuel intensive aviation to an environment-friendly industry sector.To reach this goal ALBATROSS follows a holistic approach by covering all flight phases, directly involving all relevant stakeholder groups (such as Airlines, ANSPs, Network Manager, Airports and Industries) and addressing both operational and technological aspects of aviation and Air Traffic Management (ATM). The project will demonstrate the complementary of some solutions, from alternative aircraft fuel to enhanced ATM and Airspace Users operations on the ground, TMA and en-route. To foster increased flexibility and scalability the demonstrated approaches will also leverage cutting-edge technologies, such modern as air-ground connectivity means, and novel highly collaborative ATM procedures.The possibilities of implementing a “Flight with Zero waste of Fuel and CO2 emissions” will be explored and extensively demonstrated in real conditions, through a series of live trials in various European operating environments. The demonstrations will span through a period of several months and will utilize over 1000 demonstration flights, which will be supported by Air France, Novair, Lufthansa, Wizz Air and Swiss on Airbus and Boeing aircraft, 2 Airports and major ANSPs. During this effort a strong pressure will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Amine oxidases in the deracemisation of racemic chiral amines' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

i. Characterisation of known amine oxidases: in order to improve the activity of the A. niger amine oxidase, the gene has been subcloned resulting in approximately 3 fold greater levels of expression. The enzyme has been partially purified and Turner and coworkers are trying to characterize this amine oxidize with respect to substate specificity and stereo selectivity using different substrates. We shall begin by completing this characterization in order to asses the properties of the enzyme and provide a basis for the in vitro evolution/ selection methods detailed below.ii. Directed evolution of amino acid/ amine oxidizes coupled with high-throughput screening: a major part of the project will be directed towards the generation of libraries of mutant amino acid and amine oxidizes followed by high throughput screening to identify enantioselective amine oxidizes for use in the deracemisation reactions. The similarity in apparent mechanism of action between amino acid oxidizes and type II amine oxidizes suggest that it should be possible to evolve one activity from the other.iii. Use of amine oxidizes to the deracemisation of racemic chiral amines: moreover the screening/ directed evolution work it will be necessary to determine substate specificity and stereo selectivity of the new amine oxidizes that could be discovered. New enzymes will be characterized against a defined set of substrates in order to generate a range of amine oxidizes with complementary specificities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Near real-time flood forecasting, warning and management system based on satellite radar images, hydrological and hydraulic models and in-situ data', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

FloodMan will develop methods for near real-time monitoring of flood extent using space borne SAR and optical data combined with in-site measurements, hydrological and hydraulic model data. The result will be an expert decision system for monitoring, management and forecast of floods in selected areas in Europe. The monitoring will also be used to update the hydrological/hydraulic models and thereby improving the quality of flood forecasts. The system will be based on the concept of Distributed Geographic Information network, which handles large heterogeneous interconnected spatial databases for seamless and multiscale representation of spatial data in real-time. The prototype will be validated in Rhine, Germany, Alessandria, Italy and Kemijokki Finland.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Tracking the Dynamics of Human Metabolism using Spectroscopy-Integrated Liver-on-Chip Microdevices' (OCLD), addressing dissemination and exploitation.

assistant: **Impact**

The liver is the main organ responsible for the systemic regulation of human metabolism, responding to hormonal stimulation, nutritional challenges, and circadian rhythms using fast enzymatic processes and slow transcriptional mechanisms. This regulatory complexity limits our ability to create efficient pharmaceutical interventions for metabolic diseases such as fatty liver disease and diabetes. In addition, circadian changes in drug metabolism can impact pharmacokinetics and pharmacodynamics affecting our ability to optimize drug dosage or properly assess chronic liver toxicity.The challenge in rationally designing efficient drug interventions stems from current reliance on end-point assays and animal models that provide intermittent information with limited human relevance. Therefore, there is a need to develop systems capable of tracking transcriptional and metabolic dynamics of human tissue with high-resolution preferably in real time. Over the past 5 years, we established state-of-the-art models of human hepatocytes; oxygen nanosensors; and cutting-edge liver-on-chip devices, making us uniquely suited to address this challenge.We aim to develop a platform capable of tracking the metabolism of tissue engineered livers in real time, enabling an accurate assessment of chronic liver toxicity (e.g. repeated dose response) and the deconstruction of complex metabolic regulation during nutritional events. Our approach is to integrate liver-on-chip devices, with real time measurements of oxygen uptake, infrared microspectroscopy, and continuous MS/MS analysis. This innovative endeavour capitalizes on advances in nanotechnology and chemical characterization offering the ability to non-invasively monitor the metabolic state of the cells (e.g. steatosis) while tracking minute
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Simulation tools for pollutants prediction' in the context of a Fifth Framework call.

assistant: **Objectives**

Young researchers will have the opportunity of being involved in research groups of a recognized expertise in the field of numerical simulation, reacting flows, combustion and atmospheric physics. Not only will they receive a valuable training in the fields of competence of their group, but also they will have the opportunity to interact with the rest of partners, acquiring thus a wider spectrum of competences. Moreover, they will have the opportunity of doing top-level research while keeping in mind the industrial needs and the problems encountered in applications, so they will be highly qualified both for a research commitment and for industrial work.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Chromatin-localized central metabolism regulating gene expression and cell identity' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Epigenetics research has revealed that in the cell’s nucleus all kinds of biomolecules–DNA, RNAs, proteins, protein posttranslational modifications–are highly compartmentalized to occupy distinct chromatin territories and genomic loci, thereby contributing to gene regulation and cell identity. In contrast, small molecules and cellular metabolites are generally considered to passively enter the nucleus from the cytoplasm and to lack distinct subnuclear localization. The CHROMABOLISM proposal challenges this assumption based on preliminary data generated in my laboratory. I hypothesize that chromatin-bound enzymes of central metabolism and subnuclear metabolite gradients contribute to gene regulation and cellular identity.To address this hypothesis, we will first systematically profile chromatin-bound metabolic enzymes, chart nuclear metabolomes across representative leukemia cell lines, and develop tools to measure local metabolite concentrations at distinct genomic loci. In a second step, we will then develop and apply technology to perturb these nuclear metabolite patterns by forcing the export of metabolic enzymes for the nucleus, aberrantly recruiting these enzymes to selected genomic loci, and perturbing metabolite patterns by addition and depletion of metabolites. In all these conditions we will measure the impact of nuclear metabolism on chromatin structure and gene expression. Based on the data obtained, we will model for the effects of cellular metabolites on cancer cell identity and proliferation. In line with the recent discovery of oncometabolites and the clinical use of antimetabolites, we expect to predict chromatin-bound metabolic enzymes that can be exploited as druggable targets in oncology. In a final aim we will validate these targets in leukemia and d