RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Nuclear mRNA Packaging and mRNP Architecture'.

assistant: **Objectives**

An important step of gene expression is the formation of a messenger ribonucleoprotein particle (mRNP). The messenger RNA (mRNA) is synthesized by RNA polymerase II transcribing a protein-coding gene. The mRNA is processed, i.e. capped, spliced and polyadenylated, and packaged into an mRNP by binding of RNA-binding proteins (RBPs). The RBPs bound to the mRNA are essential for the stability of the mRNP, control nuclear mRNA export and often determine cytoplasmic processes such as mRNA localization, translation and decay. Thus, the formation and composition of an mRNP is important for the posttranscriptional control of gene expression. Despite its essential nature, the mechanism of nuclear mRNP packaging and the architecture of an mRNP are still poorly understood due to the fact that mRNPs contain many different mRNAs. The overall goal of this proposal is to elucidate the mechanism of mRNP formation and the molecular structure of an mRNP. Specifically,in aim 1, we will determine and quantify the protein composition of a specific mRNP including  different stages during its biogenesis,in aim 2, we will illuminate the molecular mechanism of mRNP packaging andin aim 3, we will elucidate the architecture of an mRNP by cross-linking mass spectrometry and electron microscopy.These aims will be achieved by combining novel RNP purification strategies and the powerful biochemistry of the model organism S. cerevisiae to purify a specific mRNP with recent advances in high-end mass spectrometry and electron microscopy. In summary, the expected results of this project will show the architecture of an mRNP in its dynamic nature. mRNP packaging will be understood for the first time on a mechanistic as well as structural level. Thus, the results of this project will break new ground in ou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Upload. Urban Politics of London Youngsters Analyzed Digitally' (UPLOAD), addressing dissemination and exploitation.

assistant: **Impact**

The main aim of the proposed study is to investigate the lived experience of cultural difference among young Londoners (between 12-18 years) of different cultural backgrounds. Internet applications such as the video sharing platform YouTube, the social-networking site Facebook and micro-blog Twitter are taken as entry points to study the juxtaposition of differences in urban, digital representations. I will theorize and produce new empirical knowledge about how digital practices become loci of intercultural encounters. Taking a comparative approach, I focus on the networked belonging of youths from lower-class (often more multicultural) and upper-class (often more homogeneous) London boroughs on Facebook, Twitter and YouTube. As digital practices have become a significant part of their life, it is urgent to achieve greater insights in whether their use of Internet applications corroborates pan-European sentiments of failed multiculturalism and ethnic segregation or whether their experiences rather showcase conviviality, cross-cultural exchange and cultural hybridization. Thus far, the ways in which diverse ethnic/gender/religious identities digitally encounter, negotiate and appropriate one another across online/offline spaces have remained understudied. Innovatively bringing new media, gender and postcolonial studies into dialogue; the layered dynamics and user-generated cultural heterogeneity across Internet applications is scrutinized. The proposed study combines large-scale digital methods to study geographically tagged user-generated content, qualitative in-depth interviews with 90 youths and virtual ethnography with 30 young informants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mechanisms underlying accupational-induced irritant contact dermatitis' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

. To investigate in both humans and in a defined murine system the effects of mixed exposure to subclinical concentrations of contact irritants. To determine the genetic control of susceptibility to irritants. To describe the role of cytokines, especially TNF-a, in induction of irritant contact dermatitis. To characterize the role of heat shock protein (hsp) 70 and the induction of oxidative stress in the induction and prevention of irritant contact dermatitis reactions. To design an in vitro test to characterize the capacity of irritant compounds to regulate cytokines in keratinocytes, a test that partially will eliminate the need for animal testing.Irritant contact dermatitis affects approximately 2% of the population of the European Union, and in some risk occupations affects up to 15% of workers. Despite its prevalence however little is known about its pathogenesis although pro-inflammatory mediators (cytokines), particularly TNF-a, are thought to play a critical role. Furthermore predictive tests of irritant potential are unreliable and are only capable of examine irritants individually, whereas in many occupations several irritants may exist. This is a matter of considerable importance since there is evidence that irritants may have additive or synergistic effects.Initially, we want to titre in vivo dose/effect relationship of known irritants on the induction of clinical reaction and on cytokine induction, especially TNF-a, and oxidative stress to demonstrate a possible additive effect of irritants following mixed exposures. We want to use these in vivo findings to establish an in vitro screening assay based on the capacity of irritative compounds to induce TNF-a in cultured keratinocytes that partially could eliminate the need for animal testing. Furthermore, we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Prevention of disease caused by waste handling with special reference to en toxin and (1->3)-B-D-glucan' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The objectives of the project are to provide knowledge for the prevention of waste dust related disease through: * Coordination and optimization of ongoing research projects, * Identification of causative agent(s) and pathological reactions caused by these, development of a measurement strategy, * Evaluation of the no reaction threshold, based on dose response relationships, for establishment of guidelines, * Develop improved diagnostic criteria for disease caused by waste handling and, * Develop information material to disseminate knowledge for preventive programmesInitially, a review of information on waste dust exposure and disease will be made. This material, which is going to be continuously updated, will be available for outside use. The scientific data base will be analyzed and a state of the art article for publication in a scientific journal will be prepared. Investigations will be made of exposure conditions in waste processing facilities with different technical characteristics and with particular reference to airborne dust, bacterial endotoxin and (1->3)-B-D-glucan - a cell wall component of moulds. The importance of source characteristics, storage and waste collection for the worker exposure will be studied. Workers engaged in different parts of the waste handling industry will be examined with particular reference to the presence of airways inflammation and asthma. Persons will be challenged with bacterial endotoxin and extracts of waste dust to study the development of inflammation and obtain a basis for a no reaction threshold. In these experiments, new effect and endpoints in terms of inflammatory markers and cell reactivity will be evaluated. Animal experiments will be made to study the mechanisms behind the diseases present among waste workers with pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Protein and growth efficiency in salmonid selection' (PROGRESS), addressing dissemination and exploitation.

assistant: **Impact**

The overall goal is to establish a sufficient knowledge base to facilitate new selection programmes aimed at improving protein growth.Three major objectives are identified:1. To provide reliable heritabiity estimates for protein growth, protein efficiency and meat quality.2. To develop predictive tools to recognise the high quality genotypes of these important traits with the help of genetic correlations and growth curve models for protein growth and lipid deposition.3. To understand the biological correlatives causing variation in these traits, genetic correlations and growth curves. Six work packages form a three step work plan.The first consists of rearing rainbow trout according to a carefully planned family-based breeding scheme to provide the necessary genetic setup. The number and measurements of fish to be sampled to obtain reliable genetic information is large but has been optimised for this project by a simulation study to make it more manageable.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Secure Management Platform for Shared Process Resources' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

To pave the way forward for IS as a solution for more efficient processing and energy systems for theprocess industry, we will develop a secure ICT platform (SHAREBOX) for the flexible management of shared process resources that will provide plant operations and production managers with the robust and reliable information that they need in real-time in order to effectively and confidently share resources (plant, energy, water, residues, and recycled materials) with other companies in a symbiotic eco-system. A suite of new analysis and optimisation tools for flexible energy use and material flow integration will be developed for optimising symbiosis among companies. These tools will be based on input-output (IO) modelling for resource (waste and energy) supply-demand matching and process efficiency analysis (to understand physical and technological conditions), game theoretical (GT) approach for integrating company behaviour in cost-, benefit-, and resource-sharing (to understand economic conditions), and agent-based modelling (ABM) for designing the (economic, environmental, and social) optimal symbiotic network (to have the holistic optimum). The outputs from the SHAREBOX controller will provide plant and operations managers with commands for actions to be taken and/or recommendations for decision support. It will be ensured that all commands and recommendations a) fulfil plant operations requirements, b) are within the constraints of any contractual obligations, c) are in compliance with all regulatory thresholds, and d) deliver optimal impacts in terms of cost/savings and ecological footprints. The historical data that is generated by the SHAREBOX platform will be processed by data mining tools that will provide the production/process BIG DATA for symbiotic shared re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Improving decision-making competence and associated quality of life across the lifespan'.

assistant: **Objectives**

Across the life span, people face decisions about their health, finances and well-being. People of all ages therefore need good decision-making competence, referring to the ability to avoid decision biases and to obtain desired life outcomes. Reviews suggest that relatively little is known about how decision-making competence changes with age. However, well-documented aging-related declines in fluid cognitive abilities such as working memory start around age 20, threatening the quality of older adults’ decisions and associated quality of life. Because population age is increasing in the EU and the US, the European Commission sees maintaining older adults’ quality of life as a main policy challenge, and aims for Europe to be a leader in innovative strategies for improving quality of life across the lifespan. To address these pressing concerns, the 3 objectives of the planned research are: (1) Understanding the relationship between aging and decision-making competence across decision tasks, using validated measures of individual differences with EU samples; (2) Applying interdisciplinary insights from lifespan developmental theories to identify non-cognitive skills that facilitate better decision-making competence across the lifespan; (3) Designing and evaluating programs to build those skills that promote decision-making competence across the lifespan. The proposed work will build on new interdisciplinary insights from lifespan developmental theories and behavioral decision research, benefiting from the research program of Professor Bruine de Bruin (the applicant) who recently moved from the University of Leeds (UK) after 10 years at Carnegie Mellon University (US). Requested funds will help to move her research program to the EU, train affiliated junior EU colleagues, r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'AUTOMATED CLINICAL PLATFORM FOR PERSONALIZED ANTIBIOTHERAPY IN CRITICAL UNITS BASED ON SURFACE ENHANCEMENT RAMAN SPECTROSCOPY' (ACU-SERS).

assistant: **Concept**

Sepsis is a leading cause of death in hospitals resulting in ~700k deaths in Europe each year. Patients urgently require critical care and are admitted to an intensive care unit (ICU), where they are treated with antibiotics. However, antibiotic dosing is inappropriate in ~50% of sepsis patients, causing poor clinical outcomes due to increased adverse events, (neuro)toxicity and contributing to antibiotic resistance. Antibiotic dosing can be significantly improved through therapeutic drug monitoring (TDM), but current workflows for drug quantification in clinics and ICU are slow, expensive, and inflexible, which have greatly limited TDM implementation. We develop ACU-SERS: a first-in-class, highly flexible, fast, and cost-effective system that fully automates the biological sample pre-treatment, analyte separation and analysis and provides a quantitative antibiotic drug level concentration in ~15 minutes. ACU-SERS' breakthrough technology combines centrifugal microfluidics with an integrated surface-enhanced Raman spectroscopy (SERS) chip to perform label-free, rapid detection and quantification in an easy-to-use benchtop device. Based on the H2020 SERSing project, this project builds on developing the Raman-based analyser device and the optimal cartridge, as well as validating the scalability of the product and the system with clinical samples. From the commercial side, we will validate the commercial potential of our solution, found a spin-off company to commercialize the technology, and make it investment-ready. We envision that the spin-off will generate early revenues from direct sales in our initial target markets within the EU. After demonstrating market traction, we will seek to close a global distribution deal with a large diagnostics company for the TDM antibi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Structural Studies and Regulation of Intraflagellar Transport Complexes', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The cilium is an organelle that protrudes from the cell body and is responsible for the motility of unicellular organisms and of vertebrate cell types such as sperm cells. In addition, most vertebrate cells have primary non-motile cilia important for sensory reception and signalling. The assembly and function of cilia rely on intraflagellar transport (IFT), the bi-directional movement of macromolecules between the cell body and the cilium. As cilia do not contain ribosomes, IFT is required to move the approximately 600 different ciliary proteins from their site of synthesis in the cell body to their site of function in the cilium. IFT is powered by kinesin and dynein motors, which move cargoes along the microtubule-based axoneme of the cilium. The interaction between motors and cargoes is mediated by the IFT complex, a 1.6 MDa complex formed by 20 different proteins. Despite the importance of the IFT complex, very little is known about its architecture and how it is regulated. In this proposal, we want to address both aspects using a combination of structural and functional studies. The structural analysis of the IFT complex is daunting given its size and complexity. We are proceeding with the biochemical reconstitution of the core subcomplexes, which we plan to analyze using X-ray crystallography and electron microscopy. To date, we have solved the X-ray structure of a dimeric complex between an IFT GTPase and its binding factor, and have reconstituted one of the two core complexes (the 8-subunit IFT-B complex) in amounts and purity suitable for structural studies. While these studies are progressing, we plan to use similar approaches to tackle the other core complex (IFT-A) and the plethora of ciliary GTPases, with the ambitious goal of understanding the architecture
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a Self Sufficient Modular Mechatronic Device and Its Proof of Concept with a Workpiece Positioning Study' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Applications of microsystems have been increasing over the recent years in many fields. Microsystems are usually designed and manufactured in highly specialized establishments. The potential application of modular design and development techniques at the micro scale has many benefits. As a result of this effort, a mighty and dependable micro module can be mass produced at a very affordable price and can be used in many applications. Using common micro mechatronic modules (i.e. MechaCells) will increase the number of skilled developers, which will eventually result in increased quality in end products. Groups of these MechaCells (i.e a MechaCell Pack) can perform tasks under different conditions sharing mechanical, electrical and computing resources.The proposed project is a more focused and strengthened version of an earlier submission based on valuable feedback from the technical experts. The project proposed here in its latest form aims to take the first step towards realization of micro-mechatronic cells with measurable goals and performance requirements. Specifically, the primary objectives are to develop design requirements for a workpiece positioning application, develop mathematical and empirical simulation models and control algorithms for the MechaCell Prototype and a pack of MechaCells collaborating, and develop a macro scale workpiece positioning testbed. The proposed research  differs from the previous work in that it will focus on building self sufficient mechatronic modules (with on-board energy generation and storage and on-board distributed intelligence) rather than solely for actuation purposes. The proposed project will help the applicant establish the specific research background and testbed facilities required to take the design and development of th