RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Profiling and targeting news readers – implications for the democratic role of the digital media, user rights and public information policy' (PersoNews).

assistant: **Innovation**

In the digital media environment, user attention is scarce and competition for ‘eyeballs’ is fierce. Profiling and targeting readers with customised news and advertisements that match their individual interests is widely seen as a solution. The personalization of news media content enables new financing strategies and means to capture the audience’s attention. But personalisation is also part of a more fundamental paradigm shift in the media’s role from public interest intermediary to personal information coach. This research will answer critical questions about the implications for individual users and contribute to a new normative theory of the role of personalised media in a democratic society.To do so, this project integrates legal research, communication sciences and political sciences, undertakes comparative, normative and evidence-based research, and carries out experiments, interviews and a survey. Two communication science postdocs will conduct empirical research into user concerns, the conditions that affect users’ acceptance of media personalisation (postdoc 1), and how personalisation affects journalistic practices and ethics (postdoc 2). Informed by these insights, two PhD students will scrutinise the legal framework and answer important questions about the legal protection of the public’s trust in editorial integrity (PhD 1) and autonomous, non-discriminatory information access (PhD 2). The PI will develop a normative framework of personalised media, based on the empirical research and political theories about the democratic role of the media. This responds to the criticism that existing theories are increasingly disconnected from the realities of digital media and their distinct contribution to democratic and participatory processes. The project will expl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mitotic scaling to cell size diversity during vertebrate embryonic development' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cell division is a common process to all cell types in a multicellular organism. During mitosis, equal chromosome segregation in anaphase is regulated by an Aurora B phosphorylation gradient, centered at the midplane between the two chromosome sets. The gradient gives positional information that allows nuclear envelope reformation (NER) only when chromosomes are far enough from the kinase activity. Considering the 120μm human zygote and a 15μm fibroblast, how can the gradient scale with cell size over such wide range of sizes? To unravel the scaling mechanism, I will measure the biophysical parameters of this phosphorylation gradient using a FRET sensor and optogenetics to manipulate the gradient with fast spatiotemporal kinetics. I will address three key questions: i) Does the gradient sense cell size? ii) If so, how is size information used to scale the gradient? iii) How is gradient scaling translated into NER positioning? I will focus on three zebrafish cell systems with extreme sizes and dynamics: 1) embryonic cleavage divisions, where cell size halves with every cell division; 2) EVL cells, which are stretched quickly into flatter cell sizes, implying fast scaling dynamics; 3) asymmetric division in neuronal precursor cells, where the two sides of the spindle midzone must scale differently to generate daughters of different sizes. With this approach, I will generate unprecedented information on the regulation of anaphase chromosome separation in its natural context. This entry point in anaphase will provide a conceptual frame and a tool kit to address a more general problem: how do other mitotic machineries scale with cell size? A wider question for my long-term future research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integrated Wind Turbine Design' (UPWIND) under Sixth Framework.

assistant: **Objectives**

UpWind looks towards wind power tomorrow; towards the design of turbines (8-10MW) standing in huge on- and offshore wind farms. The challenges inherent in the creation of such power stations necessitate the highest standards in design; complete understandi ng of external design conditions; the design of materials with extreme strength to mass ratios and advanced control and measuring systems all geared towards the highest degree of reliability and critically, reduced overall turbine mass. Wind turbines grea ter than 5MW and wind farms of hundreds of MW necessitate the re-evaluation the wind turbine itself, for its re-conception to cope with future challenges. UpWind will develop the accurate, verified tools and component concepts the industry needs to design and manufacture this new breed of turbine. UpWind will focus on design tools for the all turbine components and will address the aerodynamic, aero-elastic, structural and material design of rotors. Critical analysis of drive train components will be carri ed out in the search for breakthrough solutions. UpWind will help European Wind Energy companies maintaining their favourable position in the global market, realising EU renewable electricity targets for 2010, and to attain the main objective of the Lisbon Agenda. UpWind brings together the most advanced European specialists and experience. The technical and scientific components of the programme have been integrated through a visionary organisational structure, which will ensure that scientific research an swers industry needs. This has been achieved by organising the project in such a way that the (industrial) integration work packages will guide the scientific work to a great extent . The findings of the project will be disseminated through workshops and t hroug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Efficacy of hypotensive therapy with the topical carbonic anhydrase inhibitor dorzolamide for the prevention of glaucoma in ocular hypertensive patients' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

To determine the efficacy of Dorzolamide, a topmical carbonic anhydrase inhibitor (CAI), in preventing patients affected by ocular hypertension from developing glaucoma. To validate a surrogate, end-point (for visual function) such as intra-ocular pressure (IOP) reduction to be used in clinical trials about glaucoma. Ocular hypertension has been recognized as the most important risk factor for the development of primary open-angle glaucoma (POAG). A number of drugshave been proved to be effective in lowering the intra-ocular pressure (IOP). Among those, traditional categories include beta-blockers, parasympathetic agonists, systemic CAI and sympathetic agonists. New categories effective in reducing IOP, and probably devoid of undesirable side effects, include topic CAI such as Dorzolamide. Although these new drugs are capable of reducing the IOP, as of today, a study demonstrating their efficacy in reducing the incidence of glaucoma does not exist. A randomized controlled clinical trial would allow to assess the efficacy in preventing patients affected by ocular hypertension from developing glaucoma. Our project needs the collaboration of more centres in order to enrol the adequate number of patients according to statistical requirements. The project is based on the analysis of visual function impairment in patients affected by ocular hypertension followed up to three years. Half of the sample will be treated with topic Dorzolamide and half with placebo. The occurrence of visual field defects and optic disc changes during the three years of the study will be the primary endpoints. Several inclusion and exclusion criteria will identify only patients with a primary increase of ocular pressure, normal visual function and without ocular or systemic major diseases.The patien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Genetic and epigenetic basis of adaptation to climate change' under Seventh Framework.

assistant: **Concept**

In the face of worldwide environmental damage, we need to determine the sources of phenotypic variation in natural populations to better estimate the ecological and evolutionary response of organisms to environmental threats. Here I propose to explore the molecular architecture underlying a fitness-related trait that is sensitive to environmental conditions in a wild frog. Amphibians are particularly responsive to environmental fluctuations and are undergoing worldwide decline as a result of climate change. Traits related to fitness, such as locomotor performance and the underlying muscle architecture, physiology and gene expression, are influenced by temperature in this taxa. I will identify the molecular mechanisms underlying muscle plasticity and adaptation to temperature in Xenopus tropicalis, an aquatic frog which serves as a model system in developmental biology and genetics. Specifically, I will selectively breed frogs over several generations under different thermal regimes. Some individuals will also be exposed to an additional stress (hypoxia) to evaluate the effects of tradeoffs and traits correlations on responses to selection. I will monitor the genetic changes in coding and cis-regulatory sequences of candidate loci, as well as epigenetic processes (DNA methylation and miRNA production) affecting the expression patterns of those genes. Additionally, I will perform whole-genome analyses (oligoarrays and sequencing-by-synthesis approaches) combined with quantitative genetic approaches (QTL analyses) to identify novel genes, gene pathways and epigenetic processes underlying the response to selection. Finally, in conjunction with collaborators, we will examine the biochemical, physiological and morphological (musculoskeletal) alterations associated with the re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Nlr flight simulation infrastructure'.

assistant: **Innovation**

Description:The Flight Simulation Infrastructure of the National Aerospace Laboratory NLR is offered in the Access to Infrastructures" programme of the "Human Potential programme" of the 5th Framework. The Flight Simulation Infrastructure consists of a range of Flight Simulators from simple desktop simulators to full-mission simulators with motion systems and high performance visual systems. The Flight Simulation Infrastructure has been used in major Aeronautical Research programmes, that concentrated on Flight Deck design and Human Factors (EU 4th FWP: AWARD, VINTHEC), Air Traffic Control experiments for the FAA and for NASA and Aircraft Design, with SAAB and IAI as important customers.Application:An independent selection panel (the User Selection Panel) will evaluate the proposals. This User Selection Panel will exist of experts in the field of Flight Simulation and experts on the areas covered by the proposal. The User Selection Panel will prepare a shortlist with potential research projects and present it to the European Commission for approval. Selection will be on the basis of scientific merit taking into account the interests of the Community. Priority will be given to research teams who have not previously used the infrastructure. Once approval has been given, the proposers will be contacted and the most suitable time period for the projects will be negotiated. Calls for proposals and contents of the proposals are listed on the dedicated website: http://www.nlr.nl/public/hosted-sites/ansim/index.htmlProject Manager:Alex D.J. Rutten, Afdeling Vluchtsimulatie (VS), Flight Simulation Department, Anthony Fokkerweg 2, Amsterdam 1059 CM, P.O. BOX 90502, The NetherlandsTel: +31-20-5113714Fax: +31-20-5113210E-Mail: rutten@nlr.nl"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Next generation atom chips. Planar microwave traps for experiments with cold atoms and ions/electrons' (NGAMIT).

assistant: **Concept**

The scope of this project is the experimental implementation of the next generation atom chip. Atom chips consist of planar microstructures (several µm down to 100 nm), which generate the magnetic/electric fields for confining and cooling of neutral atoms. Bose-Einstein condensation (BEC) can be regularly achieved on atom chips. The key feature of the new chips will be trapping of neutral atoms by means of microwaves. These interact with the atomic hyperfine structure and will be locally generated on the chip’s surface using planar transmission-lines, like microstrips, slotlines and coplanar waveguides. Remarkably, the novel microwave traps will enable the simultaneous trapping of neutral atoms and charged particles with a single common technology for all trapped species. The resulting atom-ion chip will become a powerful tool for studying several topics in atomic physics: collisions of ultracold atoms with ions/electrons, charge-transfer reactions, sympathetic cooling of charged particles by cold atoms, hybrid quantum computation schemes with atoms and ions, etc. The project will also focus on the improvement of the precision of some fundamental constants, like atomic masses and electronic g-factors, through the implementation of matter-wave-interferometry tools for charged particles, similar to those demonstrated for neutral atoms on chips.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Forest belowground carbon transport: From rhizosphere fluxes to physiological drivers' (RHIZOCARBON).

assistant: **Innovation**

Trees are unique in that responses at the organism level, being upscaled to forest canopies, bear large effects on the cycling and distribution of water and carbon in regional and global scales. Hence, tree carbon allocation dynamics are central not only to tree eco-physiology but also to global biogeochemistry. While tree aboveground carbon fluxes have been extensively studied, belowground fluxes, such as root respiration, growth and exudation have been mostly overlooked due to poor access to the root system. This project is set to address this knowledge disparity by answering key questions concerning belowground carbon flow.In one line of research, we will study the trees' in-house management of carbon flow, inspired by our recently achieved first comprehensive tree carbon balance calculation, which indicates that carbon reserves serve as a buffer that accommodates large fluctuations in carbon supply and demand. This will be complemented by an exploration of the inter-tree carbon supply network of mycorrhizal fungi routes, an investigation prompted by our discovery that mature trees in a mixed forest transfer unprecedented amounts of carbon among each other via fungal networks. Computational models will be applied to identify the evolutionary requirements for the development of belowground carbon transfer in a mycorrhizal network.We will dive into the highly complex soil system not in an artificial medium system  but in a mixed forest site, complemented by greenhouse experiments simulating forest tree communities. To trace below-ground carbon transport, we will apply our novel methodology of continuous, in vivo, combined measurement of 13CO2 carbon allocation and flux rate.This novel rhizosphere expedition will decipher the key belowground carbon transport processes,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sensor controlled solar powered street lighting', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Today the lighting of smaller streets and passageways is a common factor in the large suburban and village housing areas of Europe. These low density trafficated areas accounts for a large part of the energy consumption used on street lighting. It is the aim of this project to develop and demonstrate a lighting system which is activated only when there is a need for light. This could be made possible by developing long range motion sensors to activate the light only when people are using the street. 75% of the energy consumption could typically be reduced hereby dependent on the-traffic frequency of the street. With such a low power consumption this could be the break through for PV driven street lighting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fostering Earth Observation market uptake thanks to natural and holistic access to added value data generated through cutting-edge Artificial Intelligence technologies' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

SnapEarth will unlock new value, derive actionable service ideas on top of EO big data collections, and anticipate futurepriorities by leveraging cutting-edge Artificial Intelligence and Cloud technologies and tools. Thanks to an innovative cloudagnostic product, SafeScale that is already operational on Copernicus RUS project led by CSSI, users and service providerson top of SnapEarth will benefit, in a transparent way, from processing platforms and data collections provided by any of thefuture C-DIAS and any cloud provider. This cloud brokering solution is providing a performant, cost effective environment,also protecting their investment, for the future third parties which are building their own services. The major breakthrough ofSnapEarth comes with a new data analytics service, EarthSignature, which aims to automatically extract semanticinformation from satellite imagery. The extracted semantic information will be indexed by QWANT search engine and thenbe easily accessible to a wide range of user communities. EO experts and third parties will be able to train deep learningprocessing chains using their database of labelled EO images. The database will be near real time enriched. Therefore,SnapEarth allows the market move from analysing EO Big Data towards realizing Fast Data. It makes possible to buy basicimagery analysis as a commodity – much like we buy foundation data today. Several user communities are ready to engagein this new approach. SnapEarth proposes already several pilots projects. The first one (EarthSearch) will boost QWANTnumber of users through access to this wealth of data through natural language. The second one (EarthPress) involvespress users who are very interested having contextual data linked to news. The following ones are linked to several EO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Activity-dependent signaling in radial glial cells and their neuronal progeny' under Seventh Framework.

assistant: **Concept**

A significant advance in the field of development has been the appreciation that radial glial cells are progenitors and give birth to neurons in the brain. In order to advance this exciting area of biology, we need approaches that combine structural and functional studies of these cells. This is reflected by the emerging realisation that dynamic interactions involving radial glia may be critical for the regulation of their proliferative behaviour. It has been observed that radial glia experience transient elevations in intracellular Ca2+ but the nature of these signals, and the information that they convey, is not known. The inability to observe these cells in vivo and over the course of their development has also meant that basic questions remain unexplored. For instance, how does the behaviour of a radial glial cell at one point in development, influence the final identity of its progeny? I propose to build a research team that will capitalise upon methods we have developed for observing individual radial glia and their progeny in an intact vertebrate nervous system. The visual system of Xenopus Laevis tadpoles offers non-invasive optical access to the brain, making time-lapse imaging of single cells feasible over minutes and weeks. The system s anatomy lends itself to techniques that measure the activity of the cells in a functional sensory network. We will use this to examine signalling mechanisms in radial glia and how a radial glial cell s experience influences its proliferative behaviour and the types of neuron it generates. We will also examine the interactions that continue between a radial glial cell and its daughter neurons. Finally, we will explore the relationships that exist within neuronal progeny derived from a single radial glial cell.