RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Macro- and Microeconomic Analyses of Heterogeneous Labor Market Outcomes', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This proposal analyzes labor markets from both a macro- and a microeconomic perspective. It consists of four subprojects with the common objective to significantly advance our understanding of heterogeneities in labor market behavior and outcomes. The subprojects lead to novel insights regarding the intended and unintended consequences of different public policies, ranging from educational policies over the welfare state to maternal leave policies. The starting point of the first subproject are recently documented patterns of hours worked by productivity on the aggregate and individual level. Based on a macroeconomic model, it analyzes the role of subsistence consumption and the welfare state as driving forces of hours worked differences by level of development. The remaining three subprojects focus on gender. The second subproject investigates whether maternity leave policies have negative consequences for the labor market success of women of child-bearing age by lowering the expected length of a match for employers. It exploits variation in maternal leave policies across German states in an empirical analysis, whose estimates inform a frictional labor market model that allows conducting counterfactual policy experiments. The third subproject asks whether the possibility of experimentation reduces the inclination of women to shy away from competitive settings. Exploiting both within- and cross-country variation, it tests whether the reversibility of choices in secondary school has an effect on the willingness of girls vs. boys to specialize in math-intensive subjects, and thereby ultimately on educational and labor market outcomes. The fourth subproject analyzes whether an increase in the share of women in an occupation leads to lower wages in this occupation due to th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Environmentally best practices and optmisation in hydraulic fracturing for shale gas/oil development' in the context of a Horizon 2020 call.

assistant: **Objectives**

This research brings together the complementary expertise of our consortium members to gain a better understanding of the physics in hydraulic fracturing (HF) with the final goal to optimize HF practices and to assess the environmental risks related to HF.  This requires the development and implementation of reliable models for HF, scaled laboratory tests and available on-site data to validate these models. The key expertise in our consortium is on modelling and simulation of HF and all partners involved pursue different computational approaches. However, we have also some partners in our consortium which focus on scaled laboratory tests and one company which can provide on-site data. The choice of the best model for HF still remains an open question and this research promises to quantify uncertainties in each model and finally provide a guideline how to choose the best model with respect to a specific output parameter. The final objective is to employ these models in order to answer some pressing questions related to environmental risks of HF practices, including 1. How does HF interact with the natural fractures that intersect the shale seam?’ 2. How does the fracture network from a previous stage of HF treatment affect the fracture network evolution in succeeding, adjacent stages? 3.  What are the requirements to constrain fractures from propagating to the adjacent layers of confining rock?The exchange and training objectives are to:4. Enhance the intersectoral and interdisciplinary training of ERs and ESRs in Computational Science, Mining Geotechnics, Geomechanics, Modeling and Simulation 5. Strengthen, quantitatively and qualitatively, the human potential in research and technology in Europe6. Advance the scientific contribution of women researchers in this area do
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Generation of information and tools to support the management of the avian influenza crisis in poultry' (FLUAID).

assistant: **Concept**

Avian influenza (AI) outbreaks have recently caused severe losses to the poultry industry, its stakeholders and, ultimately, to the EU taxpayer. In addition, the ongoing Asian H5N1 outbreak is a serious concern for food security and human health. It is estimated that since 2000, 200 million birds have died or have been culled following infection with influenza viruses subtypes H5 or H7. Approximately 50 million of these birds were from Europe. Importantly, human infections have also been reported in several of these outbreaks. In Asia, due to both social conditions and the particular characteristics of the H5N1 virus, the crossing of the species barrier represents a serious potential risk of a new human pandemic virus emerging. The primary goal of this proposal will be the joint development and application of novel technologies to combat AI infections. This goal will be achieved through the interaction of leading European institutes along with the active collaboration of Asian laboratories. The first deliverables of the project will be diagnostic tools and vaccines to be used in outbreak management and in the application of control measures based on vaccination. A pilot study will also be conducted with the aim of developing a future EU vaccine bank. This study will allow the identification of prototype strains for vaccine production and the development and validation of companion diagnostic tests which can be used in combination with the DIVA (Differentiating Infected from Vaccinated Animals) strategy. In addition it will generate data on the presence of virus in the meat of vaccinated versus unvaccinated birds. To complement this work, studies on pathogenesis in reservoir species and on the genetic and antigenic variability of endemic strains will also be performed. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'INTERACTIONS OF ROOT PHENOTYPES AND ROOT MICROBIOME IN MAIZE UNDER NITROGEN LIMITING CONDITIONS' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Plant-associated microorganisms influence plant growth by means of the transformation of nutrients in the root-soil interphase. Nitrogen fertilization is a primary economic and environmental component of intensive maize production. Root phenotypes show a remarkable yet scarcely explored diversity at the architectural and anatomical levels of organization. Such natural variation in root phenotypes has been hypothesized to be related to adaptation under edaphic nutrient stress. The rhizosphere and rhizoplane microenvironments are microbial hotspots that may be influenced by the root phenotype. Contrasting phenotypes may have differences in root exudate localization and oxygen availability, two factors that have important effects on the composition and function of rhizosphere bacteria. In the context of the plant microbiome, previous studies have found effects of planting site, soil properties, compartmentalization (bulk soil, rhizosphere, rhizoplane, endosphere), agricultural management, and fertilization regimes on root-associated microbial communities of agriculturally relevant plants. However, the root phenotype has yet not been evaluated as possible source of variation for the plant-associated microbiome and to link this information with nutrient uptake efficiency. This proposal aims at filling this gap by combining state-of-art root phenotyping, deep molecular genetic assessment of the microbiome, and 15N stable isotope tracing to assess the influence of maize root phenotypes on the root-associated microbiome and its combined effect on fertilizer nitrogen uptake efficiency under low nitrogen availability. Such information will be useful to inform future plant breeding programs targeting root phenes and microbiomes and reduce the reliance on agrochemicals in the conte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'International Network in Theoretical Immunology'.

assistant: **Objectives**

The main aim of this proposal is to set up an International Research Network inn Theoretical Immunology that involves both experimental and theoretical immunologists. This Network will create new collaborations and reinforce existing ones in order to develop a lasting and fruitful research cooperation between all the partners.  Other objectives of this proposal are  (1) Establish a lasting and fruitful research cooperation between the experimental and theoretical immunologists of the network with the aim to provide immunology with a more quantitative basis.  (2) Establish a lasting and fruitful research cooperation between the different groups that work in theoretical immunology, with the aim to discuss, compare, test and validate different modelling approaches.  (3) Train the new generation of theoretical immunologists, with the aim to exchange postgraduate students and research fellows, so that they benefit from the broader knowledge, skills and tools provided by the Network.  (4) A final objective of the Network is to develop, by means of the Staff Exchange Scheme, four long-term directions for modelling in immunology. In particular,  (i) To develop stochastic models for the motion of pathogens and of cells of the immune system, validated by comparing with experiments.  (ii) To build a model of the immune system as a whole using stochastic dynamics of interacting populations.  We aim to understand how the system maintains its diversity of millions of lymphocyte populations and how populations of naive and memory cells are maintained.  (iii) To develop stochastic models of T cell and B cell maturation.  (iv)To develop models of autoimmunity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Hit to lead optimisation of novel anti-TB scaffolds through an academic-industrial partnership', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

We propose a PhD programme for 4 Early-Stage Researchers (ESR) in tuberculosis (TB) drug discovery. Often associated with poverty, TB is rampant in many parts of Africa and Asia but has now also returned to developed nations. Growing resistance against currently used antibiotics is one of the most pressing problems of the global TB epidemic. Treating TB infections requires a drug cocktail given for at least 6 months, extending to 2 years for infections with multi-drug resistant strains of Mycobacterium tuberculosis, the agent causing TB. A largely successful campaign by the WHO to stem the global rise of TB has not diminished the urgent need for new and better drugs and cellular targets to alleviate the devastating impact of this disease.In this project, we will train 2 biochemists/biologists and 2 chemists in TB drug discovery, initially, for 18 months at the University of Birmingham, UK, followed by 18 months at the Tres Cantos campus of GSK DDW (Diseases of the Developing World) in Madrid, Spain. Upon successful completion of the programme, the ESRs will be awarded PhD degree titles by the University of Birmingham. In their individual, yet interconnected, research projects, the 4 ESRs will work on the hit-to-lead optimisation of inhibitors of 2 novel drug targets, M. tuberculosis DprE1 and QcrB, building on preliminary work done at Birmingham in collaboration with GSK DDW.The guiding principle of this joint academic-industrial PhD programme is to provide ESRs with a comprehensive perspective on the drug discovery process. By the time they graduate, they will not only have acquired in-depth knowledge of drug discovery and optimisation, but will also have made significant research contributions to a globally relevant disease area. Finally, through their exposure to bot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Disease defence in groups: the role of relatedness, risk and pathogen type'.

assistant: **Innovation**

The ongoing COVID-19 pandemic demonstrates the drawbacks of living socially; increased contact and high host density encourage the spread of disease in social groups, compared to those living solitary. Social interactions promote disease spread, but how do animal groups deal with the increased risk of epidemics? The goal of this proposal is to identify key factors governing disease management in groups, so as to enhance our understanding of how behavioural host defences and immunity evolve. In turn, this will help shed light on how group disease defences influence social evolution. This work is crucial as the importance of pathogens as a driver of social complexity and novel adaptations is still unclear. To achieve this goal, I will use a powerful genetically and genomically established insect model organism, the flour beetle (Tribolium castaneum), to manipulate group relatedness, size and structure, as well as epidemiological risk (pathogen species and infection stage). I will then explore how these factors influence group cohesion or dissolution. By using a combination of chemical analyses to identify disease cues and recognition profiles of healthy group members during a secondment, and bioinformatic approaches at my host institution, this project will also provide a detailed picture of the underlying olfactory circuits and genetic pathways behind disease management in groups. By combining behavioural, chemical and bioinformatic assays, this project will be able to address key gaps in our knowledge of group disease defence and will have a large impact on the fields of social evolution and behaviour. The transfer of knowledge at both institutions will significantly expand my technical skillset and allow me to development of my own, independent research niche. The data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Styles of Objectivity: Agency, Alignment, and Automation in Image-Guided Surgery' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Advanced imaging technologies are currently transforming operating rooms into sophisticated augmented reality studios that explore recent developments in computer visualization, navigation applications, and robotic systems. The new imaging methods promise to increase precision and improve health outcomes. However, as medical diagnosis and therapy grow more dependent on images, the status and roles of these images become increasingly controversial. Image-guided applications reshape clinical practices, impact medical decisions, and transform the relationship between physician and patient. The objective of the project is to develop a new framework that accounts for the active role of images in surgical contexts, providing a systematic basis for handling the impact of these images and assessing their controversial aspects. The project pursues its goal through a collaborative and interdisciplinary effort that involves medical practitioners. It articulates the visual knowledge of medical practitioners by undertaking in-depth operational analyses of three image-guided technologies in current use: the 3D Slicer software application, the da Vinci surgical system, and the CyberKnife robotic radiosurgery system. The analyses introduce the notion of styles of objectivity, which accounts for the key features of these applications, including agency, alignment, and automation, while acknowledging that images have a certain agency and that there is an inner connection between aesthetic and epistemic factors. A second objective of the project is to contribute to conceptual and methodological innovation through a two-way transfer of visual literacies across medicine and humanities/social science domains, by operationalising the visual knowledge of surgical practitioners so that it can be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cascaded Optical Pulse Compressor' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Ultra-short ultra-intense laser pulses are crucial for exploring state-of-the-art research and applications in new territories of extreme nonlinear optics in physics, chemistry, biology, medicine and for industrial purposes. Most of the research is currently only carried out in specialized laser laboratories and it is a challenge to generate energetic few-cycle pulses (less than 20 fs) through a compact and reliable approach, not just in the infrared, where most pulsed lasers operate, but certainly also in the visible. In this project we focus on improving the accessibility of such short and intense femtosecond pulses in a simple, reliable way and on moving them out of the research lab and into the real-life available setups. The goal is to generate ultra-short visible and near-infrared pulses through cascaded quadratic soliton compression of longer near-infrared pulses from fiber laser amplifiers. The soliton compressor is based on cascaded second-order nonlinear processes and will employ engineered quasi-phase-matching techniques. This will reduce the detrimental pedestal of the compressed pulses, opening up for more sensitive applications such as pump-probe spectroscopy. Temporal few-cycle solitons in visible and near-infrared regions will be demonstrated both in bulk and in waveguide devices. Using this novel and simple generation of ultra-short pulses as pump for THz applications will also be explored for the first time. The motivation of the proposed project is also to make ultra-short pulses available to real-life applications. This is ensured by applying the compression technique on the promising fiber laser technology that provides a compact, efficient, stable and cheap source of laser pulses. The research results will consolidate Europe as a leader in ultra-fa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Molecular mechanisms of melanoma invasion' under Seventh Framework.

assistant: **Concept**

Malignant melanoma is highly invasive and metastatic resulting in a major clinical problem in management of the disease. The aim of this project is to gain a better understanding of mechanisms of cell migration to identify novel therapeutic targets to block invasion. Disruption of cell signalling pathways that dynamically regulate the cytoskeleton underlie the altered migratory potential of tumour cells. Rho family GTPases are major regulators of the cytoskeleton dynamics during cell migration. They are regulated by activators: guanine nucleotide exchange factors (GEFs) that stimulate GTP binding and in-activators the GTPase activating proteins (GAPs). There are approximately 85 GEFs and 75 GAPs of which very little is known regarding their role in the regulation of migration machinery. Mutations of BRAF and PTEN, two key regulators of signalling are commonly found in melanoma. Mouse models of human melanoma based on the oncogenic BRAF V600E mutation alone do not get metastases, but in combination with deletion of PTEN there is a high level of metastasis. This suggests an interaction between these two pathways leads to metastasis. Preliminary work shows cell lines derived from tumours on these different genetic backgrounds have different modes of invasion in culture. Using these cell lines, I shall carry out RNAi based screens targeting major regulators of the cytoskeleton; Rho family GTPases; Rho family GEFs and GAPs. A particular emphasis will be to screen for genes regulating protrusion formation and actomyosin contractility as these are key components of cell migration. The use of mouse lines will mean that we can carry out functional analysis of hits from screens in orthotopic invasion and metastasis assays in a mouse host background to investigate targets in vivo.