RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A coupled advanced oxidation-biological process for recycling of industrial waste waters containing persistent organic contaminants' (CADOX) under Fifth Framework.

assistant: **Objectives**

The IPPC Directive has request the development of technologies for the minimisation of pollution & for the development of water recycling. Due to the lack of available on-site technologies, a large quantity of the industrial activities included in Annex I of IPPC Direct. are not treating these wastewaters appropriately. This Proposal address to the optimisation of a hybrid technology combining solar photocatalysis, ozone and bioprocesses to the treatment of wastewaters containing Priority Hazardous Substances for permitting the reuse of this water. CADOX proposal will focus on non-biodegradable chlorinated solvents and pesticides. The expected result would be a new technology (CADOX) with market possibilities and suitable to be applied for the remediation of wastewaters with organic contaminants. This technology would be assessed by the set-up, testing and optimisation of a demonstration plant during the last step of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A.G.A.T.H.O.C.L.E.S. The ‘Archaeology of Gesture’: Apprenticeship, Tools, Hands, Organization, Collaborations, Learning Experience and Social Network Analysis' (AGATHOCLES).

assistant: **Innovation**

A.G.A.T.H.O.C.L.E.S. is an innovative approach that allow us to switch our perspective from an ‘archaeology of production’ towards an A.(rchaeology) of G.(esture): A.(pprenticeship), T.(ools), H.(ands), O.(rganization), C.(ollaborations), L.(earning) E.(xperience) and S.(ocial Network Analysis).The project aims to explore training models and collaboration networks in one of the most dynamic industries of the ancient Classical World: the pottery productive tradition. For this purpose, For this purpose, the ceramic industry is the most common reality in the ancient world to address issues of knowledge transfer, gender division and mobility.Nowadays, the study on craftsmen’s mobility needs to shift towards the analysis of hidden ancient gestures and technological procedures. Numerous technological aspects related to the ancient artisanal ‘hands’ and tools, usually invisible to the naked eye, can now become visible thanks to advances in archaeometry, computational-imaging and other innovative toolkit this project intends to adopt through an highly-interdisciplinary approach, which also include forensic and experimental archaeology).Digital humanities is also involved. In particular, Social Network Analysis can deeply innovate the methodologies used to identify workshops and provide new procedures to define groups, relationships, dependencies, and elements that can explain the organization of a complex productive network such as that of ceramic industry.Moving across from microscopic analyses to macroscopic data-processing (related to the ancient dynamics of apprenticeship), the project specifically focuses on the case-study of red-figure workshops in Southern Italy and Sicily (5th-4th century BCE). These ateliers are ideal to investigate learning experience and collaboratio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New food for special medical purposes to nutritionally manage Myotonic Dystrophy type 1' under Horizon 2020.

assistant: **Concept**

Myotonic Dystrophy type 1 (DM1) is the most common and multisystemic neuromuscular rare disease affecting 1 million people worldwide, 100,000 EU citizens, who still have no cure or treatment available. In the light of the ´Leave No-one Behind´ commitment behind Sustainable Development Goals and particularly, the dietary management approach may provide a unique option for rare disease patients through Foods for special medical purposes (FSMP), foods (not drugs) intended for the dietary management of individuals who suffer from certain diseases. The main goal of the present project is to compile in human evidences that MYODM’s food for special medical purposes is a unique approach to improve DM1 patients’ Quality of Life through a pilot clinical trial for foods and supplements sponsored by Myogem and leaded by Dr. Adolfo López de Munain, a worldwide neurologist specialized in DM1.MYOGEM is the current licensee of the patents WO2016075288 A1 and WO2016075285 A1, which disclosed the effects of some methylxanthines on DM1. Owning the Intellectual Property Rights over the present solution is one of the main competitive advantages of MYOGEM.  MYOGEM is the first and unique company worldwide who launched a food supplement for a rare disease in May 2017. However, as food supplement MYODM faces the problem that DM1 community, either neurologists and patient associations, claim for in human data in order to broadly prescribe and consume the product. To overcome this barrier, and gain market confidence, MYOGEM aims to perform a Feasibility pilot clinical trial to demonstrate MYODM’s effect on a small cohort of 10-15 DM1 patients in order to commercially upgrade our current product “food supplement” to “food for special medical purpose”, from now on referred as MYODM-FSMP, that will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nicotine actions on beta cell function in health and disease' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Tobacco abuse elevates the risk of developing type 2 diabetes (T2D). This effect is attributed to nicotine, the major addictive compound in cigarettes and chewing tobacco. Nicotine acutely activates nicotinic receptors (nAchRs) while extended exposure results in receptor desensitization. Accumulating evidence suggests that long-term exposure to nicotine impairs beta cell function. Recent results (host laboratory) demonstrate that nicotine acutely modulates insulin secretion and that reduced nAchR expression in beta cells results in an increased risk for developing T2D. This suggests that activation of nAchRs is critical for beta cell function. However, the precise mechanisms to modulate beta cell function upon long-term exposure to nicotine in healthy and metabolically compromised conditions, have not been determined yet. NACHO will investigate the effects of nicotine on insulin secretion using MafA mutant animals (model for beta cell dysfunction lacking specific nAchRs (Chrnb2/4)) and human islets. Molecular mechanisms by which nicotine affect insulin secretion will be studied by generating stable clones (CRISPR/Cas9) of human beta cells (EndoC-βH2) lacking CHRNB2/4 and evaluating cell signaling responses (calcium/sodium influx, exocytosis, plasma membrane potential) to nicotine/acetylcholine. The role of long-term nicotine exposure on beta cell adaptability will be assessed in diet-induced obese WT and MafA mutant mice treated with nicotine and evaluating beta cell function and proliferation in vivo (glucose tolerance) and ex vivo (insulin secretion and immunohistochemistry).  The clinical impact of specific nAchR gene risk alleles and nicotinic signaling on insulin secretion will be evaluated in non-diabetic humans. Understanding how nicotine influences beta cell fun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The NEO Rapid Observation, Characterization and Key Simulations'.

assistant: **Concept**

NEOROCKS improves knowledge on physical characterization of Near Earth Objects (NEOs) for planetary defense. NEOROCKS connects expertise in performing small body astronomical observations and the related modelling needed to derive their dynamical and physical properties, to the pragmatic planetary defense approach, which aims to provide operational loops and information systems to protect citizens and ground infrastructures from potential threats.The challenge for physical characterization is to keep up with the increasing NEO discovery rate. The challenge for planetary defense is to keep up with the trend of NEO discoveries dominated by small-size objects near the Earth, capable to produce damage in case of impact. Among them, are “imminent impactors” with short warning times.NEOROCKS proposes an innovative approach, focused on:a) a team of expert astronomers with access to large aperture telescopes equipped with state of the art instrumentation;b) investigating the relationship between orbit determination of newly discovered objects and quick execution of follow-up observations, to provide SW technologies to face imminent impactors threats;c) profiting from European industrial expertise on Space Situational Awareness (SSA) to plan and execute breakthrough experiments on remote tasking of highly automatized robotic telescopes for rapid response;d) extremely high standards in data dissemination, thus scaling up results to global level and exploiting results (through ASI Space Science Data Centre).NEOROCKS will optimize observational activities, enhance modelling and simulation tasks, foster international coordination and speed-up response times. It will ensure availability of results and public education. It joins top scientists with extensive NEO observation and physic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Data-driven decisions for intelligent management of public transportation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The planning and management of public transport systems is essential for urban decision makers and public and private transport operators. The key for the planning of public transport systems is the knowledge of user demand.  These data has been traditionally obtained from home surveys that are expensive, inaccurate and only show a small sample in a particular moment in time. Automatic passenger counting systems are a solution for obtaining more reliable information but the inaccuracy of the current technologies is a drawback.Counterest has developed an innovative solution that will provide decision makers in the public transportation industry with a cheap, accurate, permanent and accurate real-time travel demand information by means of 3D depth sensors and Wi-Fi signal tracking that will create a predictive model allowing for disruptive features like dynamic scheduling and allocation of resources, overcrowding detection and management, fare evasion detection, Origin-Destination matrix generation and the provision of open data on occupancy in real-time by means of an API.The target users are the public authorities and agencies managing the public transport and the public and private transport operators using bus, trams, metro and suburban rail. The need for a sustainable demand-and-service oriented and efficient public transport system indicates that there is a growing market and a significant business opportunity for our solution.We have deployed pilot installations with London Underground and 4 Barcelona Urban Bus lines that have proven our solution.The overall goal of the feasibility study is to assess the technological and economic viability of the proposed concept and elaborate a detailed business plan. The feasibility assessment will provide us with reliable marke
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CORRECTING INEQUALITY THROUGH LAW: HOW COURTS CONCEPTUALIZE EQUALITY IN THEIR CONSTITUTIONAL JURISPRUDENCE' under Horizon 2020.

assistant: **Concept**

Equality is one of the main political concerns of our time. Rising economic inequality is often cited as a major reason for the recent rise of political populism. But economic inequality is not the only problem. Inequalities based on gender, race or nationality are also major issues in the contemporary discussion. While most commentators discuss political solutions, the proposed research project analyzes the contributions that courts can make to correct inequalities. Norms protecting equality form part of all major national and international human rights instruments. However, the meaning of equality is fundamentally contested. There is no agreement on what equality exactly means or entails. The question, therefore, is not whether legal equality guarantees can tolerate inequality, but to what extent they can do. Because of these conceptual difficulties, the application of equality and non-discrimination clauses is not a straightforward exercise, in which courts simply apply legal norms to a given set of facts. Instead, courts need to develop doctrinal instruments to give meaning to the concept of equality. The proposed research project analyses how apex courts conceptualize equality in constitutional and international human rights law. It will be based on a comparative study of the equality jurisprudence of 16 jurisdictions and has three aims. Firstly, it intends to create a comparative map of equality jurisprudence, i.e. to describe and categorize the constitutional jurisprudence on equality: Which doctrinal choices do courts make and how do these choices inform the conception of equality? Secondly, it seeks to explain the doctrinal choices of the analyzed courts: Which factors influence courts to arrive at particular conceptions of equality? Thirdly, it has a normative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'OFET biosensors for point-of-care applications' (SENSE-OF-CARE) targeting Seventh Framework.

assistant: **Abstract**

Electronic, label-free biosensors characterized by rapidity and detection proved to be very promising being able to directly detect biological recognition events without the need of markers. In this respect, organic bioelectronics has gained a huge interest among scientists coming from different disciplines and sectors due to its high impact on medical, clinical, food and environmental fields. Presently Europe holds a leading position in this research area, being almost all the world-leading research groups and industrial companies in this field located in Europe. Realizing the promise of Organic electronic sensors requires research and training in crossing disciplines, such as chemistry, biology, physics, materials science, and electrical engineering. The objective of this project is to strengthen the research in this new and fast developing strategic research field by teaching and training the next generation of scientists on OFET biosensors developments both in the academia and the private sectors.Innovative OFET biosensors for point-of-care application capable of sensitive, selective and reliable detection of analytes of clinical relevance will be developed. The novelty of the proposal is the development of OFET devices that fully integrate biological recognition elements, such as antibodies or other receptors to confer specificity. Specific reactions (i.e. antigen/antibody binding) will be then used for analyte detection. However, not only medical diagnostics but also a wide range of sensing applications (e.g. food monitoring, detection of chemical, biological poisoning agents, etc.) will benefit from these new OFET device configurations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Vocal template computations in the songbird brain' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Song learning in oscine birds shares several characteristics with human language learning: it relies on social interaction, active participation, and error feedback, and must take place within a critical period. Songbirds learn their songs from a tutor: they memorize a template of tutor song and compare their own song to that template until a good match is achieved. The existence of a song template in the songbird brain has been clearly demonstrated in deafening, isolation, and lesion experiments, and therefore the songbird is one of the best animal models for unravelling neural principles of template-based vocal learning.Currently we know very little about neural mechanisms in the brain that support template-based learning. In songbirds, our knowledge about the template is limited to behavioural aspects that favour or hinder faithful imitation and to evidence about the brain areas in which the template is stored. Elusive about the template remains its neural representation, as well as the manner in which it is used for evaluating the plastic juvenile songs. Here we propose for the first time a set of experiments aimed at identifying neural mechanisms of template computations including template storage, template recall, and template-based evaluation of auditory feedback.We test the hypothesis that during singing, juvenile birds recall a memory of tutor song and use that memory to analyze and evaluate their own songs. In the zebra finch, our goal is to find a neural correlate of this memory trace in higher auditory association areas. We believe that our studies will provide fundamental insights into how the brain monitors its behavioral output and compares it to some desired output, for which a sensory template has been memorized.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Building a cooperative strategy between Europe and Mediterranean Countries for upgrading tuberculosis research and control' (EUMEDNETVSTB), addressing dissemination and exploitation.

assistant: **Impact**

Tuberculosis (TB) accounts amongst the most deadly infectious diseases worldwide. Despite the availability of a vaccine and effective drugs, Mycobacterium tuberculosis, the etiologic agent of TB, still defies the humanity. An alarming increase in drug resistance and emergence of outbreaks has made it urgent the need for increased surveillance and control. With its structured global geographical distribution, it becomes increasingly clear that this pathogen could have established an advantageous association with its host. Such region-specific host-pathogen equilibrium argues for a TB control at a regional level. The overall objective of the present proposal consists in establishing a network connecting leading institutions in the field from the three North African countries (Morocco, Algeria, and Tunisia) and Europe. The aim is to upgrade the research and surveillance capacity potential of these Europe’s most neighboring Mediterranean partner countries (MPC) through know-how sharing, two-way experience exchange, training, joint research activities, and equipment upgrading. By reinforcing existing human and technological resources in the targeted MPCs, the planned activities will contribute to better address the host and pathogen key factors governing TB transmission/expansion dynamics, emergence of drug resistance, and host susceptibility. This will endow MPCs with higher capacity to better unveil the molecular mechanisms leading to the prevailing epidemiological situation in the specific regional context. Since TB is a health threat common to both sides of the Mediterranean Sea, which is amplified through consistent population migration flows, the planned cooperative initiative could also positively impact on TB control in Europe. Ultimately, dissemination of the projec