RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'In-vivo Gene Editing by NanotransducErs' (I-GENE), addressing dissemination and exploitation.

assistant: **Impact**

CRISPR/Cas9 and enzyme-based editors hold promise for genome surgery by erasing harmful mutations and re-writing in helpful ones, but face critical barriers related to safety. Here, we propose a new concept of genome engineering based on nanotransducers (NT), which aims to make safe previously impracticable applications of genome editing and transcriptional regulation by Cas9. The methodology is based on laser-activation of a NT, which triggers a thermo-switchable double strand DNA break or cleavage. The proposed technology implements a concept of multi-input AND gates, where the output (gene editing) is true if multiple inputs are true (e.g. NT activation and recognition of 2 different loci). Indeed, the dream of unique recognition of the desired genomic target from any potential off-targets in the 3 billion base pairs of human genome would be possible. The superiority of I-GENE technology over current methodologies lies also in the multi-function integration, i.e. integration of the time function (editing only when the laser is on), the spatial function (editing only where the laser is focused) and the fidelity function (editing only if on-target) (when-where-if functions integration). Overall, this enables temporal control of single cell editing and provides an absolute safety level for developing effective genome editing for biotechnology and therapeutic applications. In the present project, proof on concept studies for technology optimization will be performed on non-mammalian zebrafish embryos. Subsequently, the therapeutic potential will be validated in a murine model of melanoma. I-GENE technology would push the boundaries of efficient and reliable ways to make precise, targeted changes to the genome of living cells that is the long-standing and main goal of gen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Impact of α-spectrin mutations on the cytoskeleton and organelle organization in neurodegeneration' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Spectrins are an integral part of the submembranous cytoskeleton providing both mechanical scaffolding and organization hub for other proteins in metazoan cells. The importance of spectrins to neuronal health is demonstrated by their association with a wide range of human neurological disorders (spectrinopathies). Currently, more than forty mutations in the gene encoding non-erythroid -spectrin (SPTAN1) are associated with developmental and epileptic encephalopathies, hereditary motor neuropathy (HMN), spastic paraplegia (HSP), and ataxia. The underlying pathomechanisms remain largely unknown. In Drosophila, the highly conserved -spec homolog similarly plays an important role in the nervous system development, as well as in synapse formation, its function and maintenance. Interestingly, synaptic defects associated with loss of -spec can be suppressed via neuronal mitochondria repositioning. Conversely, increased levels of -spec rescue a range of neuronal phenotypes linked to actin-dependent mitochondrial dysfunction in an -synuclein neurodegeneration Drosophila model. These findings suggest that modulating the levels of -spec in neurons might have an important and understudied impact on tuning mitochondrial dynamics and preserving neuronal health. Thus, the goal of my MSCA proposal is to deepen our knowledge on how neuronal actin and spectrin cytoskeleton regulate mitochondria and assess mitochondrial dysfunction at the basis of -spectrinopathies, with a combined use of Drosophila as a model organism, and human iPSC-derived neurons as a platform to translate the findings to human neuronal health and disease. My project will provide insights on whether spectrin-associated mitochondrial dysfunction is a shared or specific feature for HMN, HSP and ataxia-associated spectri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Beyond Rationality in Algebraic CFT: mathematical structures and models' (2014-2020).

assistant: **Concept**

Conformal Field Theory (CFT) in low dimensions is one of the most active branches of modern physics, it is amenable to rigorous ""axiomatic"" formulations, hence it is naturally connected to various areas of mathematical research. For example, to CFTs one can associate braided tensor categories (describing superselection sectors, defects, topological field theories) and subfactors, i.e., inclusions of von Neumann algebras with trivial center (describing extensions, duality properties and exotic charge localizations). All these areas are independently pairwise correlated, e.g., subfactors with CFTs, subfactors with tensor categories, and they have their own history and an extremely profound literature. The aim of my research project is to analyze models of CFT, together with the associated mathematical objects, which are not necessarily ""rational"", i.e., which may admit infinitely many superselection sectors (""particle"" excitations of the vacuum). Examples of non-rational CFTs (which are the majority among all CFTs) come from Virasoro minimal models with central charge bigger than one (there are continuously many), and global gauge theories with respect to a compact non-finite group of internal symmetries.Non-rationality of a CFT also implies that the ""size"" of the associated categories and subfactors have to be infinite, namely one is led to consider categories with infinite spectrum and subfactors with infinite Jones index. These mathematical objects are natural generalizations of their ""finite"" counterparts (modular and fusion categories, finite index subfactors), they are physically motivated, but they attracted the attention of researchers only in recent times.This research project aims to study structural properties of non-rational CFTs using modern machine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Atlantic network of interdisciplinary moorings and timeseries for europe' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

It is proposed to improve European scattered and uncoordinated ocean observing infrastructure for repeat/time series measurements, in order to provide an initial network of sustained moored stations for ocean CO_2 and carbon cycle measurements in the eastern North Atlantic. Existing infrastructure is upgraded/replaced with autonomous, state-of-the-art moored equipment for relevant CO_2, physical and biological measurements, at three carefully chosen sites. Part of the data will be telemetered in real-time. The three stations are tightly coordinated with the approved European ocean CO_2 system along 4 commercial ship lines, and are an essential component of a North Atlantic carbon observing system. OceanCO_2/carbon observations are imperative for understanding, monitoring, and predicting the oceanic uptake of anthropogenicCO_2. The improved infrastructure will thus provide access to strategic data for climate research and mitigation to European researchers and policy makers. At the same time, the moored platforms will be open to outside enhancements with additional sensors. Future extension of the network with more stations is encouraged.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Test an innovative support scheme for manufacturing SMEs and accelerate the use of RCTs in innovation agencies' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

This proposal outlines a programme of innovation agency experimentation supported by randomised control trials (RCTs). It focuses on the example of an innovation support initiative the partners have developed & piloted called “4Manufacturing®”. This initiative aims to support the very current topic of “industrie 4.0”: in particular it tackles the “diffusion” & adoption of industrial digitisation technologies (IDTs) by manufacturing SMEs. 4Manufacturing® appears to be highly promising based on 230 SME engagements and great appetite from regional stakeholders. It is innovative in the way that it provides a means of supporting the deployment of innovation in a manner that is structured (eg. utilising quantitative measures of adoption (attainment levels) around 22 themes). Thereby 4Manufacturing® appears to offer the potential for scale-up and enhanced return on the investment of public monies in this topic. Through this programme, and RCTs in particular, the agencies involved intend to build much more rigorous evidence for the value of this approach, and refine our understanding regarding how to refine & scale the initiative up.The findings will also facilitate the deployment of the same approach in other thematic areas, and/or particular sectors, and other geographies (eg. across the EU).More broadly still, the partners hope, through the programme, to learn how they can be more effective in experimenting the way they deliver innovation support, demonstrating the value of RCTs as a powerful tool for future policy implementation and evaluation. A key part of the programme is the dissemination (utilising the partners’ strong connections and experience disseminating across Europe) of the learnings across the EU to enable other innovation agencies likewise to experiment, using
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Global Organization from Local Signals in Neural and Artificial Networks'.

assistant: **Concept**

We propose to study how information about objects and events in the environment can be reconstructed from collections of signals each arising from a small portion of space and/or time.  The brain is continually faced with this task: eg, each retinal photoreceptor responds to light from a small bit of space compared with the size of real-world objects. In the time domain, early sensory neurons (visual, auditory and tactile) signal only instantaneous external stimuli, leaving the brain with the task of reconstructing events that extend over time (eg, speech).  Neural computation of global constructs from local signals is therefore fundamental and ubiquitous, yet our understanding of it is still rudimentary. We will use neural modeling to study the topic. We have two specific goals, addressing two tasks which we have previously characterized experimentally, behaviorally and with brain imaging.  (i) Recover the global motion of objects from local motion signals. For example, a spinning wheel's global motion corresponds to a single quantity, its angular velocity; but each point on it generates a local motion signal of a different direction and speed. The task is further complicated since other nearby local motion signals may arise from independently moving objects. The modeling will implement and test our theory that global motion computation is achieved by continual neural computation between two modules, one specializing in integration and the other in segmentation. (ii) Build models of neural networks with a hierarchical organization of Temporal Receptive Windows (TRWs). Defining a neuron's TRW as the length of time prior to a response during which sensory information can affect that response, we have recently shown that the brain is organized with a hierarchy of TRWs, ra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ecosystem-based Adaptation and Changemaking to Shape, Protect and Maintain the Resilience of Tomorrow’s Forests' (2021-2027).

assistant: **Concept**

In eco2adapt we will develop the Ecosystem-based Adaptation (EbA) framework, derived from Nature-Based Solutions (NBS), that harnesses biodiversity and ecosystem services to reduce vulnerability and build social-ecological resilience to climate change. We will work in Living Labs in Europe and China, located in climate hotspots, and adopt a cutting-edge Decision Theatre approach to investigate how forest managers integrate disturbance and vulnerability into decision-making. Scenarios of how disturbance affects forest dynamics and ecosystem services at a landscape scale will be derived through modelling, and in Living Labs, stakeholders will learn how their choices affect ecosystem services in neighbouring forests. We will combine interdisciplinary knowledge from scientists and stakeholders in Europe and China to understand perception and provide incentivization for adopting EbA solutions, through local capacity-building and national policy plans. Through the same Decision Theatre methodology, we will use a capacity-building approach to create and promote innovative technical, economic and governance mechanisms at a regional level. Semantic technology will be applied to create a knowledge base for hosting FAIR data and creating a SmartPhone Application (named the OneForest ToolBox) that allows users to access and add data concerning climate-resilient species, provenances, mixtures, management techniques and ecosystem services, whilst taking into account future uncertainties about climate and societal changes. We also provide a suite of cutting-edge tools to monitor vulnerability and resilience (including invasive species and above-and below- ground biodiversity), at all levels of society – from the citizen to the policy-maker. By including tailored communication to all l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'OFF-network Wireless communications for Emergencies and General Operations' (OFF-WEGO).

assistant: **Innovation**

In today’s world, we fully rely on the existing commercial communication systems for our daily activities, from quotidian tasks to the most critical governmental duties. Our assumption is that such infrastructures are always available, but there are many situations where fail. In order to guarantee the communication services (especially when referred to mission-critical forces but also for the optimised performance of companies), the EC has addressed some main challenges: 1) The protection against fails, attacks or natural disasters; 2) The deployment of fast and autonomous networks; and 3) The interoperability of heterogeneous networks without manual involvement. However, current communication systems cannot guarantee such premises, as sadly shown by the dozens of millions of user connections interrupted each year in the EU and, even worse, 29% of them affecting 112 emergency calls. These failures bring not only a severe threat for the European economy, but they can also result in injury or death to first responders and other people during an emergency situation. OFF-WEGO will overcome these problems by providing a new solution for mobile voice and data communications that will enable, for the first time: 1) Total resilience against deliberate or accidental failures (immune to common failures and protection of communications by encryption); 2) Fast and autonomous deployment (no need for cumbersome infrastructures or complex procedures); and 3) Broad Interoperability (acting as gateway to different and heterogeneous networks). At company level, this project will represent the culmination of several years of R&D and an inflexion point in the evolution of our sales, turnover, profit and job generation. But more important, OFF-WEGO will bring unique opportunities for guara
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Textile Excellence in EU-MED Partners' (TEMP) under Seventh Framework.

assistant: **Objectives**

The project main goal is to enhance the S&T cooperation in the Textile & Clothing field between Portugal, Italy and Tunisia by reinforcing strategic partnerships in this 3 research entities and 3 Innovation Promotion Associations. This will be achieved by combined actions and activities, such as: - Exchange and mobilization of human and material resources between partnering organizations; - Knowledge transfer in the field of water management; environment performance; scientific laboratorial analysis; IPR; and other S&T expertise areas; - Disseminating scientific information and knowledge as so as the results of S&T research; - Implementation of RTD past project results and best practices in the textile and clothing industry of the MED country and convergence region; -Provide technical assistance and training aspects to enhance the knowledge transfer; - Definition of specific S&T priorities in partners regions, creating a research agenda for the period of 2010-2013, with the objective of launching research projects in the 7FP. - Create a Contact Platform with other scientific fields of mutual interest and benefit like the shoes sector, trying to improve contacts in all the fashion industry of the partnering countries. The expected impact of these activities will be a better integration of EU and MED countries; improve S&T capacities in the MPC (Mediterranean Partner Country) country and convergence region helping the reinforcement of the regional economic and social development; create fruitful links between partners organization and further RTD organizations in the partnering countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Analysis of mice and cells lacking jund' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content The JunD protein clearly functions differently from related Jun proteins, but it's precise role in physiological and cellular response to stimuli is unknown. The surprising observation that inactivation of the junD gene results in mice that are viable presents a unique and powerful tool for analysis of JunD function. Furthermore, our results are unlike those obtained by inactivating other AP- 1 genes or genes known to inhibit cell growth. These mice will provide exciting insights into the specific function of JunD by allowing a detailed analysis at the molecular, cellular and physiological levels. The proposed study of fibroblast and Iymphocyte function in vitro should highlight JunD-specific function in controlling cell growth and particular induced gene expression programmes. We expect to uncover specific JunD-regulated events associated with cell growth, cell death, transformation and cell cycle. Furthermore, we will gain an appreciation of overlapping and non-redundant roles for different Jun members. This understanding will serve as the basis for investigation in vivo analysis of JunD function in physiology and pathology. Training content (objective, benefit and expected impact) This study will allow me to expand my knowledge and expertise in cellular and molecular biology. I will be able to contribute significantly my background in leukocyte gene expression, cellular interactions with the extracellular environment, and growth and movement of transformed cells. It will give me training in several important new areas including transcription factor biochemistry, mouse genetics and physiology, isolation of primary cell cultures etc. This breadth will strengthen my ability to function as a competent and creative scientist within the Euro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Thematic network for understand mobiliby prediction' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The objective of the THINK-UP network is to draw together results on transport demand forecasting and scenario, building, and to discuss and compare the methodologies used, the underlying hypotheses, and the results obtained. THINK-UP will be open to policy makers (at European and national level), operators and users and will work in close relation with a research team. Four main themes will be discussed through a number of small workshops and larger seminars, organised in three phases: initiation of the Thematic Network, concertation of the actors and validation of results. This themes are transport services and user needs for freight, institutions and policies, prediction tools and related research. Results will classified policy objectives, validate segmentation of transport markets and present and discuss models used at European, national and sectoral level.