RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evaluation of the synergy between tamoxifen chemotherapy and hypericin photodynamic action, following mitochondrial complex III photo-inhibition: Towards a combinatorial anticancer treatment modality' (HYPERTAM).

assistant: **Concept**

In the present Marie Curie Intra European Fellowship application, HYPERTAM, we propose to combine our recent complementary findings in two separate anticancer therapeutic modalities, namely, photodynamic therapy of cancer (PDT) with hypericin or other phototoxins and tamoxifen chemotherapy, fusing them in one combinatorial treatment predicted to demonstrate enhanced antitumoural potency through synergy of tamoxifen action with hypericin photo-inactivation (inhibition) of mitochondrial complex III quinoloxidizing centre. The main points to be addressed by HYPERTAM are summarized as follows: (i) Revisit and expound the tamoxifen - complex III inhibitor cytotoxic interplay findings. (ii) Explore the predicted hypericin PDT-tamoxifen synergistic action in selected cell models. (iii) Evaluate other photosensitizers with high clinical relevance. (iv) Investigate the cell death pathways implicated in the most striking in-vitro results (v) translate the most important in-vitro combinatorial treatment results to corresponding animal models for a pilot preclinical assessment.The fellowship is expected give the applicant a unique opportunity to acquire key skills and knowledge like: (i) competences in molecular biology including evaluation of cell death mechanisms and pathways (ii) competencies in the use of novel lab techniques and instrumentation (iii) certified competencies in animal tumour models. (iv) competencies in management, administration and entrepreneurial activities. The possibility to run HYPERTAM represents a unique opportunity for the applicant to perfect his professional profile, and at a very critical juncture, steer his career towards independent research. The expected result of the proposed project, a cross-disciplinary bimodal anticancer treatment modality wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Monolithic Widely Tunable Interband Cascade Lasers \nfor Safety and Security'.

assistant: **Objectives**

The WideLase proposal focuses on compact, rugged and cost effective laser sources with wide tuning range for safety and security applications in the 3.3 to 7.0 µm wavelength range.Three particular challenging applications with significant market potential are investigated within the project. There are no suitable application grade semiconductor lasers for these sensor applications yet available on the market. The aim of the WideLase proposal is to overcome these limitations and to achieve the following goals:Novel Interband Cascade based laser structures with wide gain bandwidth will be realized enabling room temperature continuous wave operation. The developed structures will exceed existing Quantum Cascade Laser performance figures in the targeted mid infrared range.Novel monolithic concepts for electrical tuning based on multi-section DFB as well as acousto-opto-electronic lasers will be developed for the first time in the wavelength range of interest. This will result in monolithic devices with an unprecedented tuning range of up to 200nm formerly in reach only by external cavity lasers, which are not suitable for the targeted applications mainly because of their high cost and their lack of ruggedness.These novel high performance photonic sources will allow the development of the following highly sensitive detection systems:<br/>- Laser based sensor for remote detection of alcohol against drunk driving- Laser based sensor for formaldehyde monitoring- Laser based sensor for hydrocarbon leak detection.<br/>In order to reach these goals, significant challenges have to be overcome in various fields, ranging from epitaxial semiconductor growth via laser design and processing to mid infrared sensor development. The consortium comprises renowned research groups, academic a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Investigation of the role of a phytopathogenesis-related pka from sclerotinia sclerotiorum' (1998-2002).

assistant: **Innovation**

A mutant strain of S.sclerotiorum, deleted of the gene coding for protein kinas A, will be constructed and analysed as to its ability to produce lyric enzymes and to infect host plants. Novel information will be gained concerning the signalling that controls the regulation of enzymes genes in phytopathogenic fungi.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Development, modelling & application of time temperature integrator system to monitor chilled fish quality'.

assistant: **Innovation**

Despite the increasing demand for fresh (chilled) fish in Europe and the decreasing total catch of fish for human consumption, large amounts of fish and fish products are wasted due to spoilage, usually due to mishandling. This situation could be significantly rectified through a modern quality assurance approach, which is based on prevention and requires monitoring, controlling and recording of critical parameters through the product's life cycle from production to final use. To establish such a system for chilled and minimally processed fish products, it is necessary to acquire a thorough knowledge of the relation between storage conditions and shelf life, expressed in quantitative terms i.e. effective and accurate predictive models. Further there is need to validate and develop practical systems to monitor and record these conditions from catch to consumption. Time Temperature Integrators (TTI) are such systems. Based on the aforementioned needs the main objectives of this project are:- To compare existing empirical temperature models with spoilage data for fish species not previously studied, packed fish and minimally processed fish products.- To develop new empirical models, if required.- To study in detail the shelf life loss modes of specific chilled fish products, in order to establish effective kinetic shelf life models that will allow accurate correlation of fish quality to variable storage, handling conditions and the initial level of spoilage.- To develop simple and easy-to-use Time Temperature Integrating software that allow existing and new predictive models to be combined with product temperature profiles from temperature loggers, for effective chill chain quality monitoring.- To assess existing and develop and model new TTI devices that have the required
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Study on the influence of nitroxyl (HNO) and nitric oxide (NO) bioactivity on potato defense against pathogens: on the lookout for improving the global food supply.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Potato (Solanum tuberosum L.) is one of the world’s most important crops for human consumption, thus it is an integral part of the world's food supply. Poland is the world's 8th largest producer (2nd in the EU), with 9 million tons annually. Potato is susceptible to a wide range of pathogenic organisms, which can cause severe quality and yield losses worldwide. Given the absence of cultivars resistant to pathogens and the immunization of pathogen isolates to successive fungicides, any attempt to understand and strengthen the knowledge of factors related to natural potato immunity is extremely important.In light of this, it is well documented that nitric oxide (•NO) is a key element involved in pathogen recognition as well as activation of local and systemic plant defense signaling activities and pathways. Moreover, the interdisciplinary group proposing this plan recently reported endogenous production of HNO (nitroxyl) in plant tissues (Arabidopsis thaliana) for the first time, and points toward a novel regulatory role. Under physiological conditions, HNO concentration in plant cells is in the nanomolar range. The ubiquitous HNO bioavailability allows it to support or compete with •NO signaling, depending on the local redox environment (shifts with stress or senescence). Finally, we showed that HNO formation is an early reductive stress-related response.Taking all this into account, this proposal will focus on the real-time detection and visualization of simultaneously endogenous HNO and NO in leaves of the important crop plant challenge inoculated with vr/avr Phytophthora infestans, a cause of late blight disease. Moreover, it will be an important issue to answer the question of whether and to what degree the HNO presence in cells modifies the plant's defense responses
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sound Engineering For Aircraft (SEFA)' (SEFA).

assistant: **Innovation**

The aim of SEFA is to develop technology design criteria (Sound Engineering) based on a thorough assessment of which characteristics would make aircraft more acceptable for airport communities from a noise signature standpoint (spectral and directivity shapes, impact of separation time, ...), addressing from a complementary perspective the concerns of close communities (peak periods of activities with short separation time), distant ones (high altitude traffic with low background noise) and disturbance from night operations. As of now, such criteria do not exist and so far, aircraft noise engineering has focused on achieving ever lower noise levels for individual events and at close distance from the runway. The project objectives are consistent with the Framework 6 workprogramme on Aeronautics and Space, promoting open upstream research for reduction of noise at source as well as improved understanding of the impact of aircraft noise in the community. Thanks to its technical scope and workplan, SEFA is aimed at addressing both aspects and has the ambitious goal of improving the relationship between the technology optimisation process and how the resulting aircraft sound is perceived. Through improved optimisation of noise reduction concepts, SEFA will have a significant strategic impact in reinforcing the competitiveness of the European Industry while addressing the long term Vision 2020 environmental goals. A novel approach, based on Sound Quality engineering practices, will be used to define optimum aircraft community noise shapes. These targets for aircraft sound optimisation will be validated by psychometric testing. To support the definition of design criteria able to meet these target sounds, innovative simulation tools (virtual aircraft and virtual resident) wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The extended EEN innovation support service for innovative SMEs in Serbia — EEN Client Inno Journey' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In Serbia, as in other parts of the world, small and medium-sized enterprises show comparative advantage due to flexibility, i.e., rapid adaptation to changes in the environment, the entrepreneurship and the innovativeness. On the other hand, this group of enterprises has a problem with providing specific resources underlying the innovations, but also the problem of solvency, i.e., to fund innovative activities. Which is typical for the economies with limited capital and restrictive investment policies, such as Serbia.Taking into account all this, the Enterprise Europe Network could play a crucial role in bridging the gaps of knowledge, resources and skills that could be essential for increasing the innovation capacity of SMEs, especially in experience and knowledge sharing, training and consultation EEN could provide assistance to managers and entrepreneurs in all phases of the development of new products and services, from concept to commercialization. The overall objective of EEN Client Inno Journey is to increase Summary Innovation Index of Serbia providing services that will help to foster innovation and drive a fast growth of Serbian economy.The EEN Client Inno Journey project aims to deliver 50 (fifty) 7-day package services with the following distribution among the two groups of targeted SMEs: •8 packages dedicated for Key Account Management for the beneficiaries of the SME beneficiaries of the European Innovation Council (EIC) Pilot under H2020 in 2020 or potential successor programme to the European Innovation Council in 2021, and •42 package services delivered for enhancing the innovation management capacities of the SMEs with significant innovation activities. Partners will follow a client-centric approach, focusing on supporting the client's needs throughou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The atomic-layer 3D plotter', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Micro- and nanofabrication represents important mainstream manufacturing processes across several industrial fast-growing sectors, such as MEMS & sensors, optics & photonics, RF devices, semiconductors, printed electronics, which in turn are significant building blocks in e.g. advanced healthtech, biotech, cleantech, and electronics. Yet, to improve the market stance, the micro-/nanofabrication sector is looking for solutions able to reduce costs and time spent on the prototyping and fabrication process, as well as more flexible, efficient and sustainable solutions, able to utilize a broader range of materials permitting custom-built components. While the most promising technology to address these challenges is found in the 3D printing market, there are currently no available 3D printers or technologies with the capabilities to address these challenges. To this purpose, ATL (DK) has developed the ATLANT3D Nanofabricator, a 3D nanoprinting technology with improved resolution and flexibility, while costing less 27% than the closest 3D printing competitor, and up to 92% less than conventional competitors. It will enable rapid prototyping, shorter time to market and lower barriers for companies and researchers already working in this field, as well as those for whom micro-/nanoprototyping is currently not feasible. The overall aim of ATOPLOT project is to mature, extend capabilities and prove full functionality and benefits of the ATLANT3D Nanofabricator. ATOPLOT brings together a consortium of three SMEs (ATL, FEM, SEMPA) and two academic partners (FAU, SAS) – in unison representing a technical side specialized in nanofabrication, and a business side with experience in business development and B2B sales & marketing. The consortium expects a successful market introduction o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Modelisation of bonded joints' under Fourth Framework.

assistant: **Concept**

Research objectives and content THE AIM OF THE PROPOSED PROJECT IS TO STUDY THE BONDED JOINTS, WHERE TWO ADHERING PARTS ARE LINKED BY AND ADHESIVE WHICH HAS A VERY SMALL THICKNESS. WE PLAN TO DESCRIBE IT AS A 'STRUCTURED' SURFACE: THE ADHERENTS ARE CONNECTED ALONG THE COMMON BOUNDARY BY A NON CLASSICAL TRANSMISSION CONDITION. BY APPLYING A WELL CODIFIED TECHNIQUE, WE WILL STUDY THE CASE OF LINEAR ELASTIC, NON LINEAR ELASTIC, VISCO-ELASTIC, ELASTO-PLASTIC ADHESIVE, TAKING INTO ACCOUNT THE CONSTRAINT OF IMPENETRABILITY BETWEEN THE ADHERENTS. THE ADHERENTS WILL BE CHARACTERISED AS GENERIC 3D BODIES OR AS 2D BODIES (PLATES, SHELLS, ETC.). FURTHERMORE, WE WILL ANALYSE THE DYNAMICS OF THE JOINTS. THE MAIN RESULTS OF THE PROJECT CONSIST 1) IN FURNISHING DIFFERENT MODELISATIONS OF THE BEHAVIOUR OF THE BONDED JOINT, EACH APPLYING IN DIFFERENT CASES; 2) IN CHECKING (THEORETICALLY, NUMERICALLY AND EXPERIMENTALLY) THESE MODELS; 3) IN DEVELOPING A UNIFYING VISION OF THE NEW AND OF THE OLD MODELS DEVELOPED INDEPENDENTLY AND 4) IN CONSTRUCTING THE ACTUAL (NUMERICAL OR ANALYTICAL) SOLUTION OF THE MAIN PROBLEMS ARISING IN THE APPLICATIONS. Training content (objective, benefit and expected impact) A PERIOD OF STUDY IN ONE OF THE EUROPEAN MOST FAMOUS UNIVERSITY POLE (JUSSIEU) WILL FURNISH A GREAT ADVANCE IN THE SCIENTIFIC AND CULTURAL GROWTH OF THE APPLICANT. IT WILL BE POSSIBLE TO RELATED WITH A WIDE NUMBER OF FAMOUS SCIENTIST, TO INSERT IN A INTELLECTUALLY VIVACIOUS ENVIRONMENT AND TO WORK ON THE MOST ADVANCED TOPICS OF RESEARCH. THE TRAINING WILL ALSO BE USEFUL FOR THE HOST INSTITUTION, BECAUSE IT WILL HAVE A FREE, FULL-TIME QUALIFIED PERSON WORKING ON ONE OF THE RESEARCHES THEME OF THE LABORATORY. Links with industry / industrial relevance (22) THE RESULTS WILL HAVE A DOUBLE INTEREST
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Forensic Hydrogeology' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Contaminant events disrupt stability and resilience of increasingly vulnerable soil and groundwater. Identifying where, when and how much contaminant spill is released into aquifers is critical for strengthening the competitiveness of EU in risk-reduction management, and Forensic Hydrogeology, a growing discipline that applies scientific knowledge in legal resolutions. Existing model solutions estimate the origin and affected area, but numerical challenges impose too restrictive assumptions to properly account for multiple sources or suitable aquifer characterization. The scientific goal of FORENSHYD is to develop a novel, flexible and reliable ensemble Kalman filter data assimilation method (EnKF) for the optimal identification of contaminant sources and occurrence of reactive pollutants in near-actual conditions. Latest assessed developments of Dr. Gómez-Hernández set EnKF as an excellent optimization tool for the simultaneous identification of the spatial variability of conductivities, the location, and the release function of polluting sources. A step toward coupling the algorithm with machine learning techniques may overcome ill-posed solutions, stemmed from nonlinearities between parameters and variables in the state equation, to solve kinetic-controlled reactive transport problems and to optimize data collection in groundwater observation network systems, a topic of renewal interest in administration and industrial sector. We test spurious effects of aquifer heterogeneity, reactive parameters, and initial/boundary conditions in synthetic scenarios, sandbox experiments and two demonstration sites. Transfer of this novel technology in well-reported, practical and universal open source packages will reinforce the leadership and employability in the global market of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Future Directions in Brain/Neuronal Computer Interaction (BNCI) Research', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Brain Computer Interface (BCI) systems allow communication through direct measures of brain activity. Users can spell, move cursors, browse the internet, and control robotic devices such as prosthetics or wheelchairs with thought alone. BNCI systems are similar, but can also rely on indirect measures of brain activity. Rapid progress in BCI and BNCI research is creating a number of new opportunities across a much wider range of potential users than previously recognized. Unfortunately, the many new developments and new research groups lead to two problems. First, key terms and definitions are confusing, outdated, nonexistent, and/or only sporadically accepted by people and groups from different backgrounds. There is no clear agreement on fundamental terms like BCI and BNCI. This confusion impedes development of standards and roadmaps for both academic and commercial efforts. It is also difficult to organize conferences, workshops, special journal editions, expositions, or electronic collaboration resources for a field that is unknown and poorly defined. Second, there are widely differing views on how to capitalize on recent progress and which avenues for future development merit the most attention. These problems will only get worse without an effective coordination effort. It seems unlikely that any project can align constituencies and prepare future joint researches and roadmaps when the relevant disciplines and stakeholders are not even clearly identified. Future directions in BNCI systems (Future BNCI) will identify which opportunities are (and aren't) promising across all four components of a BCI system: sensors and signals; signal processing; applications and devices; and interfaces and operating environments. These four components will be addressed through three