RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Towards Applications of the Si=C Bond in Organic Synthesis and Pharmaceutical Chemistry: Chemo- and Stereoselective Reactions with Silenes' to be submitted under Sixth Framework.

assistant: **Abstract**

Compounds with Si=C double bonds, so-called silenes, have traditionally not been considered interesting for organic synthesis. To change this fact, the groups of Dr. Ottosson at Uppsala University, Sweden, and Dr. Steel at Durham University, UK, have recently established a collaborative research program exploring selective reactions with Si=C bonded compounds and the further synthetic elaboration of the products formed. Simultaneously, it has been clarified that Si-containing compounds have no general inherent toxicity due to Si, and that exchange of a C atom to Si in bioactive compounds represents a novel direction in lead discovery in pharmaceutical research. Selective reactions with Si=C bonded compounds should be highly suitable for inclusion of Si in cyclic bioactive molecules. It is now proposed that Dr. Dominik Auer, an inorganic silicon chemist with a recent Ph.D. from Univ. of Wurzburg, Germany, starts on a project that bridge the areas of fundamental silene chemistry, organic synthesis, and pharmaceutical chemistry.His principal supervisor will be Doc. Ottosson at Uppsala, and co-supervisors will be Dr. Steel at Durham on synthetic applications of silenes, and Dr. Bursne, associate director of Dept. of Medicinal Chemistry at AstraZeneca R&D Mulndal, Sweden. It is proposed that Dr. Auer spends the major time in Uppsala (12 months) and shorter secondments in Durham (3+3 months) and at AstraZeneca R&D Mulndal (3+3 months). The highly interdisciplinary nature of the project meets the needs of European science for well- trained multi-skilled workers and in addition connects academic and industrial research. This is optimal for Dr. Auer who has the ambition to embark on a research career in industry. The project provides him with the essential skills to act in an ef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'StructUral ProtEins foR Biomedical materials'.

assistant: **Objectives**

The SUPERB project will train an experienced researcher (ER), Dr. Diego López Barreiro, in the modelling and manufacture of protein-based polymers for healthcare materials. The ER will combine building blocks of structural proteins like elastin or collagen into de novo fusion protein polymers. The healthcare community is becoming increasingly interested in these polymers as a source of advanced healthcare materials, due to their natural abundance, tuneable degradation, easy processability, cytocompatibility, or controllable physicochemical properties. This project will study how polymer features and processing conditions determine the nanostructure of the materials derived thereof, and hence their macroscopic properties. This will be done through an interdisciplinary approach that will (i) use molecular dynamics simulations to select protein sequences and processing conditions for material manufacture; (ii) biosynthesise selected proteins via fermentative processes; and (iii) fabricate, test and characterise hydrogels or thin film materials for model validation. The excellent knowledge and expertise of the host institution in this crucial field for the EU will ensure the success of this proposal. This project will develop a methodology to improve the rationality and decrease the time needed to develop new protein healthcare materials, reducing animal use and experimental costs. Moreover, while the proposed approach is used here on a limited suite of protein building blocks, it can be applied to any other peptide sequences or biopolymers (e.g., bioactive peptides, bioplastics, nanocellulose), becoming a valuable tool to accelerate the discovery of healthcare materials. Furthermore, the project will support the ER in deepening his expertise in protein materials and expose
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'An innovative approach to boost wheat yields'.

assistant: **Concept**

All wheat breeding programs in the world and particularly the European ones are urgently looking for significant yield increases. Many recent reports state that EU countries are confronted with stagnating wheat yield potentials. In the last 10-15 years, the major wheat breeding companies in Europe, like Limagrain, KWS, RAGT, Syngenta, Bayer etc., were under great pressure to stay on the market. In this situation, they resorted to the concept: “Cross the best with the best, select the best, and hope for the best”. This approach directly implies the narrowing of genetic diversity, without which plant breeding cannot be successfully conducted, especially for the wide range of European agroclimatic conditions. The aim of the proposed project is to produce and offer to both private and public wheat breeding programs information and/or hybrid wheat seeds obtained from selected crosses found to possess great potentials for the expression of heterosis (hybrid vigor) for grain weight and size. The project is based on an innovative approach which claims that high hybrid seed vigor for the weight and size of grain obtained on mother plant after controlled hybridization in a range of environments could be an exceptional source for selection and/or breeding in conventional breeding programes, breeding of double haploid (DH), or hybrid wheat production. Thus, the genetic potential of desirable „novel gene recombinants“, in the form of either products, services or both, offers new opportunities for further yield improvement. So far, basic scientific and production concepts have been tested and in the 2013/2014 season we found extremely promising crosses which can be used commercially. A feasibility study, which will assess the practical, technological and financial potentials of this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Efficient Electronic Services for Tourist in Action'.

assistant: **Innovation**

The ESTIA project aims to provide the means for mass adoption of Business-to-Consumer (B2C) E-Commerce in the tourism sector. The project is introducing value-added services over the next generation access medium of E-Business: Mobile Networks, in order to efficiently support individuals and vendors in the tourism economy.More specifically, this project will provide the following tools and services:Easy and cost efficient access to travel information (and all associated info) during the actual holiday trip.Brokering tools and platforms for locating, reserving and purchasing domestic products & services better matching their needs.Personalised services including recommendation and bundling services that best complements their tourist plan and schedule and matches their tourist identity and travel profile.On line virtual communities of groups of people that belong to their target segment, travelling along them that build virtual trails in order to be easy located from other un-informed travellers and people at home.Objectives:As On-line Commerce evolves, services will become increasingly supportive, cost efficient and consumer-oriented in order to add value to current business practices. Also in the Tourism industry, suppliers are offering innovative useful services, by making use of the Internet. However the focal point of the Tourism business, i.e. the tourists demands during their travel, remains insufficiently addressed. It is clear that the mobility of travellers urges the development of new mediation platforms that will focus on supporting them at their destination place and building-up exploitable relationships, which will be maintained after the actual trip.The ESTIA project aims to contribute to the economic development of the Community by providing the means for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Promoting inquiry in mathematics and science education across Europe' (PRIMAS) under Seventh Framework.

assistant: **Objectives**

This project aims to effect a change across Europe in the teaching and learning of mathematics and science with teachers supported to develop inquiry-based learning (IBL) pedagogies so that students gain experience of IBL approaches. Ultimately, our objective is a greater number of students with more positive dispositions towards further study of these subjects and the desire to be employed in related fields. The proposal brings together 13 teams of experts in IBL in mathematics and science education from 12 nations and will be led and managed by a researcher who has recent successful experience of European work of this type. The nine working packages will be led by appropriate experts from the wider team, who will ensure the successful completion of each stage of the project. Overall, our design of the project throughout has been focused so as to provide a multi-level dissemination plan addressed to teachers and important stakeholders to ensure maximum impact. This plan includes the provision of high quality support for, and training of, teachers and teacher trainers; selection of high quality materials and methods with which to work with teachers, supporting actions addressed to teachers to advertise IBL, methods of working with out-of-school parties such as local authorities and parents and summaries of analyses that will inform a wide range of policy makers about how they can support the required changes. Throughout the project’s timeline national consultancy panels and two international panels will provide on-going advice and orientation at key stages. To maximise the project’s “reach” to teachers either established networks for professional development of teachers will be expanded, or new networks will be built using models which have proven efficacy. Rigorous eva
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Analysing of utrophin minigenes for functional replacement of dystrophin deficiency using transgenic techniques'.

assistant: **Objectives**

There is currently no effective therapy for Duchenne muscular dystrophy (DMD) the most common and severe of the muscular dystrophies affecting approximately 1 in 3000 males. Recent publications on that subject show that one possible therapy to compensate for the lack of dystrophin in patients who suffer from DMD might be the upregulation of the highly homologous autosomal utrophin. This assumption is based on the fact that utrophin is found at the sarcolemma in early human fetal life becomes restricted to the neuromuscular junction once dystrophin is expressed. In the mdx mouse, the animal model of DME utrophin expression is high in muscle at birth but declines during the first weeks of life, during which time the animal begin to develop myonecrotic lesions. It will be challenging to examine whether utrophin can replace dystrophin in vivo using transgenic techniques. Therefore, the outlined proposal will focus on the production and detailed analysis of mdx mice which . transgenic for the utrophin gene under the control of a strong muscle promoter. Training content (objective, benefit and expected impact) Prof. Davies group at the Department of Biochemistry at the Oxford University is one of the leading laboratories in the research field of muscular genetic disorders with a very high international reputation. The proposal has been formulated in collaboration with Prof. Davies. The Oxford group can provide excellent expertise and experience in all technologies necessary to carry out this project successfully. Therefore I can aquire a lot of modern methods widely applicable in the research fields of molecular genetics, biochemistry and cell biology. In summary, I regard the facilities and resources (libraries, courses and seminars) available at the University of Oxford mos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Using museum specimens to understand mushroom population genomics.' in the context of a Horizon Europe call.

assistant: **Objectives**

Museum collections and other repositories contain a vast amount of specimens associated with metadata detailing the location,habitat and ecological observations of the specimen at the moment of collection. Since these specimens are biological tissues, DNAsequencing techniques can be used to study them. However, their application to fungi is still very limited. One of such applications ispopulation genomics, a field where fungal study is also severely lagging behind that of plants and animals. The combination ofsequences from museum specimens and fresh material will allow us to study populations of two mushroom-forming fungi,Trichaptum abietinum and Phelopillus nigrolimitatus. T. abietinum is an abundant species that is emerging as a model for population studies, with abundant information in Scandinavia. Museum samples will allow us to detect potential changes in selective forces that have affected Norwegian populations, mainly associated with landscape changes over the XXth century. P. nigrolimitatus is a Scandinavian Nearly Threatened species whose populations have been dwindling in association to land usechanges. Museum samples will allow us to compare past and current genetic diversity of Norwegian populations, which will helpinform conservation efforts. The project will generate SNP chips, which will help future population and conservation studies by providing a reliable and cost-efficient analytical tool. MUSHEUM will combine population genomic data with specimen metadata and ecological information to study selective pressures in the two species. Finally, MUSHEUM will make use of the combined genome skimming data generated for the design of SNP probes to generate de novo genome assemblies of the two species. This advances will allow to repurpose data from populatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Knowledge assessment on sustainable water resources Management for irrigation'.

assistant: **Objectives**

KASWARMI's main aim is to deliver fundamentals for future research activities by improving the sustainability of irrigated agriculture in LA. In many developing countries the socio-economical pressure to increase agricultural production is in conflict with the preservation of the environment and with other users of the natural resources.The intensification of the agricultural production in arid and semiarid regions includes activities such as irrigation and fertilisation, often associated with inadequate management and lack of knowledge, which produce serious contamination problems. European experiences (EU: Germany, Spain, Hungary: [3 partners]) with approaches to sustainable agriculture and the Water Framework Directive can support the specific regional experiences in Latin America (LA: Chile, Argentina, Bolivia, Brazil: [6 p.]). KASWARMI fosters such EU-LA cooperation regarding the interdisciplinary approach and the specific regional socio-economic, ecological, and technical (s-e,e,t) conditions.The specific objectives of KASWARMI are:- To develop a comprehensive knowledge base in sustainable water resources management for irrigation and an interdisciplinary scientific network;- To carry out an integral multi-stakeholder analysis of different (s-e,e,t ) situations in selected irrigation areas in LA;- To build up and intensify direct contact to stakeholders (farmers, other water users, policy makers), schools and civil society organisations; and- To detect the stakeholders? needs for research.- In this context research strategies and a concept for future joint research based on requirements of the stakeholders will be developed.The dissemination will be achieved through strategies for future RTD activities, publications, brief informative bulletins (L A, local), the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PROBING THE ROLE OF SODIUM CHANNELS IN PAINFUL NEUROPATHIES' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Neuropathic pain is a frequent feature of peripheral neuropathy adversely impacting patients’ quality of life and increasing health care costs. Not all individuals with neuropathy develop pain and it is not possible to predict who is more or less susceptible among those with similar risk exposure. Inability to identify high-risk individuals and drug-responder patients and lack of drugs acting on target sites for which there is strong evidence of pathogenicity explain the disappointing effect of current treatments. The PROPANE STUDY aims to address these issues through a solid clinical and genetic approach employing an innovative technological platform. The main objectives are to resolve the genetic architecture of painful neuropathy achieving a stratification of high-risk neuropathic pain patients by novel biomarkers, to deepen understanding of underlying mechanisms and druggable targets and to identify new molecules tailored to potentially drug-responder patients and determine their effects in pre-clinical settings. Results will advance the field beyond the current  state-of-the-art opening a window upon a validated individualized pain medicine and having an innovative impact both on patients’ care and market applications. These aims will be achieved by a complementary approach based on targeted sequencing of the 5 sodium channel genes expressed in the nociceptive pathway and identification of new targets by unbiased whole exome sequencing and transcriptome assay. Melding of these two approaches offers a close-to-optimal balance between highly-focused, challenging but clearly achievable goals (sodium channels in pain) and a broader unbiased approach that will capture and deliver other targets and approaches from our unique patient population. Our strong preliminary fin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mediterranean Neurosciences Network' under Seventh Framework.

assistant: **Concept**

Europe and MPC possess a good potential of well trained researchers in the field of brain function and dysfunction in disease. However, neuroscience remains poorly represented in collaborative projects amongst the Mediterranean and European countries. Yet, as the MPC access to the status of developed economies, they face severe health burden of brain dysfunction in relation with developmental issues, education, aging, neurodegenerative diseases, mental and addictive disorders. It is thus crucial for the MPC to invest in this theme of research. In this context, N€UROMED aims at supporting MPC research institutions infrastructure and potential development in brain research. The project, built on existing collaborations and local networks, gathers a strong human potential from 23 Universities and research centres and complementary expertise in basic and clinical neuroscience. More precisely, the objectives are to promote and improve: (1) twinning between centres of excellence in the EU and the MPC; (2) recruitment, training and secondments in MPC centres; (3) transfer of knowledge and know-how to the MPC research centres; (4) physical research infrastructure in MPC centres. Focusing on 4 major relevant societal issues (neurodegenerative and mental diseases, neuroplasticity, adaptation to environmental stress and brain imaging), where cooperation with EU research entities can help increase the human potential and physical infrastructure in MPC, N€UROMED will pave the way to the creation of solid links amongst institutions in MPC and Turkey, and to step up Euro-Mediterranean Cooperation in the field of Neurosciences. In parallel to the implementation of specific activities, N€UROMED will also improve the participation of the MPC to the FP7. Finally, the project is expected t