RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Remote control for improved reservoir management - demonstration project' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Current equipment for use down-hole in multilateral wells to optimise the efficient, flexible control and fluid flow is proving to have a poor reliability when operating in the harsh environmental conditions experienced down-hole. With the trend towards deepwater wells with their higher temperatures and pressures and harsher environments, there is a need for a new generation of technology to meet these requirements.The EC-funded JOULE III research project entitled Remote Control for Improved Reservoir Management" has researched and experimentally evaluated enabling technology for use down-hole in multilateral/multi-zone. A demonstration project is now proposed to take this work a major step forward.The main objective is to prove and demonstrate, to potential user/operators, a system configuration for a new generation of highly reliably remote control systems for improved reservoir management using the latest technology and techniques resulting from the RECONFIRM project."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Chromosome-based mechanisms of transcriptional inactivation during mitosis'.

assistant: **Innovation**

Coordination between major cellular functions, such as transcription and proliferation, is critical to ensure cell survival. It has long been recognised that while in mitosis, cells switch-off most of their transcriptional activity. While Mitotic Transcriptional Inactivation (MTI) is entrenched as a dogma in cell biology, its functional consequences have been difficult to pin down, as manipulating MTI in the context of a developing organism has been difficult until now. My lab has pioneered the use of acute perturbation approaches to dissect cellular process with unprecedented temporal resolution, which hold the prospect of surpassing current limitations on the identification and manipulation of multiple MTI layers. Using these novel approaches, ChromoSilence aims to test the hypothesis that MTI is a vital process for proper genome partitioning and transcriptional control. We will focus our analysis on chromosome-based events, that we propose as key contributors for MTI regulation, and test how classic chromosome assembly factors impact on mitotic transcriptional shutdown. In parallel, and supported by strong preliminary observations for a putative candidate, we will identify and reveal the function of novel players involved in chromosome-based mechanisms to drive MTI. New knowledge on the MTI mechanisms will be used to develop tools to uncover the role of this transcriptional shutdown in the fidelity of nuclear division and thereby identify novel routes to maintenance of genome stability. We will additionally uncover how the transcriptional silencing during mitosis may impact on maintenance of transcriptional programs in various developmental contexts. Collectively, ChromoSilence will reveal that MTI is not a by-product of passage through mitosis but instead an essenti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Clustering Individual TRuck Owners' (CITRO) targeting Fifth Framework.

assistant: **Abstract**

In Europe there is a large number of individual truck owners without a sound organisation and poorly supplied with suitable support tools. A large percentage of small truck owners still work alone. This situation reduces consistently the investment and innovation capacity, inducing these figures to remain in subordinate and unsteady positions, sometimes on the margin of the regular market. Even though they are already organised in associations or co-operatives, a number of difficulties remain to overcome (for example the need to ensure to every member a balanced treatment in comparison with the other members). The project is addressed to this category, aiming to tackle and solve problems that are common to the groups of truck owners participating in the project. The suggested approach is to support the clustering of these truck owners and provide them with advanced organisational models and ICT tools to compete with larger companies.Objectives:The main objective is to support the clustering of individual truck owners and small transport companies into modern structures able to guarantee a good level of internal organisation and collaboration, by means of the use and the diffusion of ICT tools. The intention is to define and experiment a Best Practice instrument as a way to study the existing organisational models and the previous experience of the consortium's partners, aiming to improve and modernise them.The organisational models deal with three main aspects:a) a balanced distribution of the work among the truck owners;b) a sound and regulated communication between the truck owners and the structure;c) a good co-ordination of the logistics.Particular attention is paid to a better and wider use of ICT tools, since it is necessary, for the small owners organisations, to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Synthetic Oxygen-related molecular Systems in plants' (SynOxyS) targeting Horizon 2020.

assistant: **Abstract**

Aerobic organisms developed systems to measure cellular oxygen levels and activAerobic organisms developed systems to measure cellular oxygen levels and activate adaptive responses in case hypoxia occurs. This condition can be caused by sudden environmental changes or associated with developmental programmes. Recent reports have revealed that complex eukaryotes, such as plants and animals, converged towards the recruitment of dioxygenase enzymes to regulate gene targets at the transcriptional level. However, while the sensing strategy is the same, the molecular identity of the components involved is different. The similarities and differences between animal and plant hypoxia machineries can be exploited to acquire better understanding of the dynamics of oxygen sensing in the two kingdoms and more precise manipulation of these mechanisms for farming proposes. Here, I plan to apply a novel approach that merges the synthetic biology framework, molecular physiology and developmental biology to transfer features of the metazoan oxygen sensing and delivery systems to plants. This strategy will be instrumental to investigate for the first time whole oxygen machineries and characterize their performance in the context of plant cells. More specifically, the proposed project expands in three distinct although interlinked directions that explore (1) the exploitation of 2-OG dioxygenase to drive selective proteolysis in higher plants, (2) the investigation of endogenous or heterologous control of chromatin accessibility by 2-OG dioxygenases and (3) the engineering of a synthetic delivery delivery system to alter oxygen provision or perception specifically to shoot apical meristems. The process of design and optimization of these synthetic oxygen machineries, and the comparison with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Well-Aging and the Tanycytic Control of Health' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The survival of an organism depends on energy homeostasis, involving the control of neuroendocrine functions that integrate metabolic feedback and adapt the response of the organism to physiological demands. Tanycytes, specialized glial cells lining the floor of the third ventricle in the median eminence of the hypothalamus, act as linchpins of these processes, dynamically controlling the secretion of neuropeptides by hypothalamic neurons into the pituitary portal circulation and regulating blood-brain and blood-cerebrospinal fluid exchanges, both processes that depend on their morphological plasticity in response to the physiological state. In addition to their barrier properties, they actively shuttle circulating metabolic signals to hypothalamic neurons that control food intake. The overarching goal of WATCH is to synergistically employ state-of-the-art technologies in systems neuroscience, mouse genetics and bench-to-bedside research, to explore the role of these unique and versatile cells, providing new directions in biomarker research and new therapeutic approaches for a variety of disorders that impair well-aging. Our specific aims are:1. Genetic dissection of the in vivo regulation, pathophysiological function and molecular markers of tanycytes classified according to their anatomical location.2. Identification of novel heterogeneous, molecularly distinct tanycytes and associated endothelial cells and determining how these characteristics evolve under distinct physiological and pathological conditions.3. Functional validation of newly classified subgroups of tanycytes and the specific modulation of the activity of these subgroups at the experimental level.4. Exploration of the functional consequences of pharmacologically activating pathways required for the tany
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'New diagnostic system for specific and fast detection of multiple nucleic acid mutations by PNA hybridization on an array sensor'.

assistant: **Objectives**

(1) Technology-related: Finding, designing and synthesis of a sensitive and PNA:NAspecific dye; fixation of PNA on useful solid supports; specific hybridisation of DNA with solid support-bound PNA; detection of PNA:NA hybrids by specific dye interaction; development of bread boards for detection.(2) Application related: Development of a working model with the new dye using model DNA sequences related to selected p53 mutations; application of the working model to representative sS3 mutations from clinical samples.At present, nucleic acid (NA) diagnostic systems are based on hybridisation between NA analytes and NA probes labelled with a reporter group. This type of hybridisation is limited regarding sensitivity, specificity, complexity, hybridisation conditions, and the need of prior probe labelling. To overcome these limitations new diagnostic principles for specific and fast detection of NA will be investigated which are obtained by specific hybridisation of PCR products of diagnostic relevant analyte sequences with solid support-bound PNA. In case of PNA the entire backbone has been replaced by a backbone composed of N-(2-aminoethyl)glycine units leaving the nucleobases intact. Although this alternative backbone chemically does not even remotely resemble the deoxyribose phosphodiester backbone of DNA, it is structurally homomorpheous to the DNA backbone. The PNA duplexes of mixed purine/pyrimidine sequences with Watson-Crick-like helix structures are more stable than the corresponding NA:NA duplexes, but the kinetic parameters are similar for the formation of PNA:NA and PNA:PNA duplexes. Since PNA is a pseudo-peptide, chemical modification and conjugation is fairly straight forward. Recently it has been shown that known NA:NA hybrid-interacting dyes interact in a diff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'A synthesis method for hybrid separations'.

assistant: **Innovation**

1.Interactive flow-sheet generation methodology based on separation efficiencies. The advantage and unique feature of this methodology is that it guarantees feasibility of separation, pollution prevention and near optimal (if not optimal) energy consumption, without requiring rigorous simulation and optimization studies. The methodology is simple and visual;2.Computer aided tools to validate and verify hybrid separation schemes;3.The project enables consulting service and corresponding software to identify candidates for application of hybrid separation schemes and candidate separation techniques (including selection of external agents such as solvents and membranes);4.The project will also open the road to consulting service to generate alternative separation schemes with lower energy consumption and improved environmental impact;5.Advanced numerical tools and methods for the solution of this type of optimisation problems;6.development of innovative flow-sheets for the processes that have been selected for the industrial cases.The aim of the project is to investigate and establish a new methodology that is able to synthesize and design multi-functional separation processes with a view to enhanced efficiencies in terms of energy/separation and improved control of environmental impact, employing hybridization and process intensification principles. In particular, - Investigate alternative and/or novel separation processes for energy intensive separations, that may involve hybrid separation technologies, e.g. membrane distillation, reactive distillation etc. - Investigate suitable modelling/analysis and synthesis techniques that enable the identification of hybridization possibilities and the potential benefits compared to conventional processes, on a systematic basis. -
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Calabi-Yau manifolds and higher potential functions'.

assistant: **Innovation**

Calabi-Yau manifolds arise naturally in algebraic geometry as objects with certain special structures. In theoretical physics these geometric objects define super symmetric models of the universe via string theory. String theory in turn constructs a hierarchy of functions on the parameter space of Calabi-Yau manifolds, the so-called higher potential functions. In the context of algebraic geometry, the mathematical understanding of potential functions is far from complete. The aim of this project is to develop the understanding of higher potential functions by analogy with the well-understood case of tree-level (level 0) functions. In more detail, the objectives of the project are the following:-Interpret mathematically the computations of closed string higher-level potential functions on Calabi-Yaumoduli spaces found in the physics literature; establish the connection of potential functions and categories defined by the geometric objects; apply the obtained mathematical constructions to the study of parameter spaces of geometric objects, and-analyse the correspondence between spaces of matrices and open strings on families of Calabi-Yaumanifolds, recently discovered by physicists; in particular, compare symmetries of the two sides. The project involves an interdisciplinary component, aiming to bridge a gap between mathematics and theoretical physics. It also involves a training component, developing expertise of the Researcher in areas where the host institution has particular strengths: matrix models, Hodge theory and representation theory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Study of membrane lipid composition and alpha-synuclein spreading' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Neurodegenerative pathologies (NDs), including Parkinson’s disease, represent a huge burden worldwide from a health, economical and societal point of view. However, the physiopathology of these diseases is not well understood, making the discovery of a cure extremely hard. A common feature of NDs is the accumulation of misfolded proteins such as alpha-synuclein (asyn) in different types of proteinaceous aggregates, the formation of which follows a prion-like spreading mechanism. In this context, the host lab has extensively studied the capability of neuronal and non-neuronal cells to transfer asyn through Tunneling Nano Tubes (TNTs). However, the causes and mechanisms of a asyn misfolding and accumulation are still poorly understood. Asyn is a lipid-binding protein, that associates with the head of phospholipids, and it is involved in the regulation of vesicles trafficking. Given the ability of asyn to directly bind membranes, studying the lipid composition of asyn-interacting membranes appears to be pivotal to understand its function and the consequences of its misfolding on the cell homeostasis and metabolism. In this regard, a peculiar class of glycerophospholipids, called N-acylethanolamines (NAPEs), which are enriched in the neuronal membranes after injurious stimuli, have been shown to regulate the binding and stabilization of proteins that interact with the inner leaflet. The present proposal aims to investigate the role of NAPEs in asyn anchorage to membrane, and how the perturbation of membrane lipid composition is affecting asyn spreading in vitro and in vivo. The combination of pharmacological, biochemical and molecular biology techniques applied in various neurodegenerative models and my strong knowledge in NAPE biology and metabolism, together with the expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A european research arena on intangibles' to be submitted under Fifth Framework.

assistant: **Abstract**

We are moving fast o a knowledge-based economy. But our analytical tools are no longer useful for decision-making. This leads to an inefficient allocation of resources, increases the uncertainty, thus preventing the efficient functioning of S&T policy. In this general context, the main objective of the Network is to create a European Research & Communication Arena on Intangibles, bringing together excellence centres on intangibles from different European Countries and countries from the rest of the world, to analyse knowledge production, acquisition and diffusion by companies and its implications for Science, Technology and Innovation Policy. This objective will be reached through four activities: Activity 1. Mapping Centres of Excellence, Activity 2. Intellectual capital statement in firms, Activity 3. Policy implications. New Research Agenda and Activity 4. Policy implications. Future training needs. As a result of the project a virtual network of all the excellence centres in knowledge management world- wide will emerge, a refined theory of intangibles will be produced, which will serve as an starting point for the discussion of a new European research and training agenda, that will have the consensus of a wide range of agents.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Renewable Energy Sources Power FOrecasting and SyNchronisation for Smart GriD NEtworks MaNagemenT' (RESPONDENT) targeting Horizon Europe.

assistant: **Abstract**

Renewable Energy Sources Power FOrecasting and SyNchronisation for Smart GriD NEtworks MaNagemenT.Renewable energy sources (RES) play a major role to the EU’s aspiration to transform to a climate-neutral economy. Their integration into the power grid is pivotal to the green transition and to the decarbonisation of the energy sector. However, as the most commonly used RES (solar, wind and hydropower) are also weather-dependent, their power generation capacity varies according to the local microclimatic conditions. This power production variability makes RES difficult to integrate into the power grid and to provide seamless, stable and secure amounts of power. On the other hand, power demand also affects the power grid operation, since there must always be a supply/demand balance in the power grid. Grid power imbalances can cause frequency fluctuations and other unwanted transient phenomena, which can compromise grid stability and operation. For that matter, advanced grid monitoring techniques have been developed, employing phasor measurement units (PMUs) to measure the electrical signals in a precise and synchronised way, based on a reliable timing reference. Yet, currently, no Galileo-based applications on PMU timing exist.  In the above framework, RESPONDENT comes to address the challenges of RES power generation forecasting, demand forecasting and smart power grid monitoring and supply/demand balancing. An AI/ML RES power generation forecasting algorithm is proposed, exploiting both Copernicus EO and site-specific weather data, along with renewable energy power conversion models. Furthermore, an AI/ML – multiphysics model for power demand of certain communities is also developed. Lastly, RESPONDENT will build a Galileo-enabled PMU and develop a monitoring module, in o