RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Extreme Soliton Driven Light Sources' (XSOL).

assistant: **Concept**

Many important breakthroughs in science have occurred when investigating the laws of nature at extremes. Strong-field effects, such as relativistic plasma dynamics, high-harmonic generation and laser-driven particle acceleration, appear at extreme intensities of electromagnetic fields. By using very short laser pulses and focusing them very tightly, these effects and their applications come within reach of table-top systems. I will explore extreme strong-field physics at the fundamental limits of spatio-temporal confinement and open the door to a completely new regime of strong-field interactions in the vacuum ultraviolet. I will achieve this by scaling soliton-driven light sources in hollow capillary fibres by two orders of magnitude in power compared to the state of the art.I will create optical attosecond pulses (sub-cycle electric field transients in the visible part of the electromagnetic spectrum) with multi-terawatt peak power and excellent pulse contrast, with homogeneous linear polarisation, circular polarisation, or as radial vector beams. The latter can be focused to sub-wavelength spot sizes and create a relativistic electric field in the longitudinal direction. In combination with the sub-cycle duration, this will be a completely unique driving pulse for plasma physics and particle acceleration. I will use these pulses for the generation of high-energy isolated extreme ultraviolet and X-ray attosecond pulses from plasma mirrors and for the creation of isolated multi-MeV attosecond electron bunches using in-vacuum strong-field electron acceleration, both in a compact table-top system.I will generate few-femtosecond pulses tuneable across the vacuum ultraviolet (100 nm to 200 nm) with 300 GW peak power, opening the door to a regime of ultraviolet-driven stron
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Conformational determinants of enzymatic per- and polyfluoroalkyl activation and selectivity'.

assistant: **Objectives**

Per- and polyfluoroalkyl substances (PFAS) are persistent and pervasive environmental contaminants. Long-chain PFAS bioaccumulate in plants, humans, and wildlife, amplifying their toxicity and health risks, leading to increasing governmental regulations. Shorter-chain PFAS are being phased in by industry to replace longer-chain PFAS, but their toxicity is less known and they are harder to detect, highlighting the need for increased monitoring. The overall situation calls for rapid, accessible, and on-site methods to detect, differentiate, and break down diverse chain-length PFAS. To address this challenge, I propose to investigate ‘fluoro-selectivity’: the capacity of enzymes to differentiate between PFAS of varying chain-lengths and fluorinated versus non-fluorinated compounds. Strikingly, fluoro-selectivity already occurs in enzymes in nature. Here, I propose to use a combination of bioluminescence and machine learning to decipher the fluoro-selectivity code of natural enzymes that undergo conformational changes in response to different PFAS. In tandem, I will establish a new method using a fluoro-selective resistance mechanism to discover environmental enzymes capable of breaking down fluorinated compounds. Finally, I will take advantage of the close structural similarity between firefly luciferases - the enzymes that enable fireflies to glow - and natural PFAS-activating enzymes known as acyl-CoA ligases. Leveraging this evolutionary relationship, I will construct fluoro-selective, bioluminescent enzymes to enable the design of real-time, in situ, and chain length-specific PFAS biosensors. Mapping the first blueprint of enzymatic fluoro-selectivity will enable precision applications in environmental PFAS monitoring and remediation. More fundamentally, this work aims
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Commercialisation of a Novel and Efficient Air Compressor to Improve the Economic Viability of Hydrogen Fuel Cells' under Horizon 2020.

assistant: **Concept**

Ongoing environmental and health concerns associated with the use of fossil fuels is driving demand for clean energy sources. For example, countries including China, the UK, Germany, India and France intend to ban new internal combustion vehicles within ~20 years. Battery powered electric vehicles have an important role to play, but they continue to be limited by range and charging time, so there is increasing interest in alternatives such as hydrogen fuel cells. It is predicted that by 2032, over 22 million fuel cells will be in operation. Fuel cells consume stored hydrogen and oxygen (from air) to produce electricity. Heat and water are the only by-products, so the technology is non-polluting at the point of use. However, fuel cells are still relatively expensive and a key way to reduce their cost is to supply air at higher pressure, using a compressor. This increases power output, allowing them to be made smaller and cheaper, but compressors can consume up to 40% of the energy produced by the fuel cell, so their efficiency is critical. Aeristech’s compressors operate much more efficiently, requiring 10-20% less power than competitive products. They are also up to 20% smaller and will operate continuously at high power for 4,000 hours without servicing.  These unique advantages are creating enormous commercial interest.Our solution, FC-eCompressor, has been developed to prototype stage (TRL6) and we now need to optimise the technology for production and gain approvals for commercial supply. To achieve this, we must produce sample units that are manufactured using high-volume production techniques, but this is expensive and time-consuming. By overcoming this barrier, we will open-up market opportunities that will create at least 110 new jobs and generate over €65 milli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Global-Warming-Optimized Aircraft Design', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The high-level objective of the proposed GLOWOPT project is the development and validation of Climate Cost Functions (CCFs) with respect to minimizing global warming and their application to the multidisciplinary design optimization of next-generation aircraft for relevant market segments. Several objectives are set in order to reach this target. The first objective is to provide an overview of the state of the art on the scientific background of the relation between aircraft design and operation and its climate impact. The second objective is to derive characteristic aircraft design requirements, primarily payload and range, based on statistical data analysis of the worldwide aircraft fleet and route structure for future entries into Service using a comprehensive air traffic forecast model. The third objective is to develop climate cost functions for the use in the aircraft design optimisation, which reliably represent the climate impact of CO2, NOx, H2O emissions, as well as contrail-cirrus effects. The fourth objective is to perform a Multidisciplinary Design Optimization with respect to the climate cost function to find a set of operational parameters, design parameters and aircraft technologies that minimize the climate impact of the aircraft design using an existing MDO environment that applies the developed CCFs as objective function. The fifth and final objective is to perform an assessment of the aircraft designs chosen in order to quantify their impact on important metrics such as landing and take-off noise, emissions and cash operating cost. For this purpose, a higher-fidelity simulation integrating existing flight performance, emission and climate impact models is adapted and applied to simulate the aircraft design solution in an operational environment.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Trapping and Killing Glioblastoma'.

assistant: **Innovation**

Glioblastoma Multiforme(GB) is an aggressive brain cancer associated with a 2% 5-year survival rate and 250,000 new diagnoses globally.Gold standard treatment includes surgical resection and radiotherapy coupled with Temozolomide(TMZ) chemotherapy that promote cancer cell death.Resistance to TMZ and radiotherapy develops rapidly due to DNA repair mechanisms, indicating that targeted disruption of them can potentiate these therapies. TrapKill combines cancer mechanobiology, microfabrication and biomaterials engineering to develop a pioneering therapeutic trifunctionalised hydrogel,physically modified to present 3D microchannels,and chemically functionalised with GB chemoattractant CXCL-12 and TMZ.These promote durotaxis/chemotaxis-mediated GB cell infiltration,constraining cells into elongated morphologies,stressing the nucleus,disrupting DNA repair mechanisms,and rendering cells susceptible to therapies. I have shown that 3D patterned hydrogels promote GB GL261 cell infiltration,forcing cells to adopt a filamentous conformation and subjecting the cell nuclei to significant shear/tension/compressive forces.Following microchannel sequestering,preliminary data indicate that cells upregulate stress-related signalling processes and lose the protective effects of cell agglomeration.It is envisaged that TrapKill glioblastoma therapy will significantly enhance the efficacy of gold standard chemo-radio-therapy approaches. TrapKill objectives include:A chemoattractant-TMZ functionalised and micropatterned hydrogel to create TrapKill therapy Analysis of microchannel dimensions on GB cell morphology,nuclear stress and cell sensitivity to TMZ/gamma radiation in vitroAssess transcriptome changes in mechanically stressed GB cells and in DNA repair gene transcriptionPre-clinical resect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'A Simulation-based Framework for Measuring and Modeling the Impact of Attacks on 6G-enabled Massive IoT Networks'.

assistant: **Innovation**

As the deployment of 5G networks is in progress, the researchers and engineers are now shifting their attention towards developing the next generation of mobile networks (6G), which is expected to provide Tbps wireless connectivity with ultra-high reliability and extremely low latency (less than 1ms). The new generation of mobile networks, which is expected to be commercialized by 2030, are envisioned to offer much wider range of applications comparing to 5G by interconnecting billions of IoT devices such as extended reality devices, wearable displays, drones, and autonomous vehicles. Definitely, the unprecedented growth of 6G-enabled IoT devices along with the massive emergence of connections in the future 6G communication platform will increase the security vulnerabilities for the 6G-enabled massive IoT networks, leading to a wide spectrum of known and unknown security threats. Therefore, there is an urgent need for developing novel security solutions for massive IoT networks, taking always into consideration their resource-constrained limitations, before they gain the trust of all involved stakeholders and reach their full potential in the 6G era. Toward this direction, REACT aims to develop a simulation-based framework for measuring and modeling the impact of attacks on 6G-enabled massive IoT networks. The proposed simulation-based framework is envisaged to be the first comprehensive IoT security solution which will (a) become publicly available to the IoT security research and industry community for reproducible experimentation and reusability purposes, and (b) also have a high scientific impact by contributing significantly to the efforts against the urgent need for novel security solutions to protect the upcoming 6G-enabled massive IoT networks.


**Keywords:** S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'International Working Group on Natural Hazards in the Tien Shan' to be submitted under Sixth Framework.

assistant: **Abstract**

We propose to establish an international and multidisciplinary Working Group on Natural Hazards in the Tien Shan Mountains of Central Asia. This initiative follows the recognised need for efficiently linking natural hazards research, integral risk management, and environmental protection via cooperative support activities between European, Russia, and NIS experts. In a First Stage", we focus on hazards from slope instability. We thereby aim to contribute to sustainable development during the current transition phase in the NIS. Our key objective is to jointly identify, rank, and illustrate high-priority research needs on slope instability, and ensuing risks to the region's population, infrastructure, and environment.A comprehensive review and critical evaluation of existing information will be collated in a regional-scale "Hot Spots & Crucial Gaps" map and catalogue. This activity will actively contribute to disseminating previously unavailable research results between European and Russian/NIS researchers. We further intend to develop from these data project sketches, recommendations, and feasibility assessments for use in future collaborative research activities and joint RTD proposals. Together with the identified "Hot Spots & Crucial Gaps", the se project sketches will also be valuable tools for strategically coordinating RTD activities, optimally targeting and allocating of funds and resources, monitoring scientific progress, and augmenting geospatial data on natural hazards in the region. Regional "supply and demand" will be summarised in a project portfolio on former, present, and planned hazard- and risk-related projects in the Tien Shan.Finally, we will host coordinated and cost-efficient activities to strengthen awareness, skills, and capacity building and know
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Antidiuresis using short-acting vasopressin-v2-receptor agonists as a new treatment strategy of urinary incontinence and voiding disorders' (ACTION).

assistant: **Concept**

More than forty million middle-aged and elderly EU-citizens suffer from urinary voiding disorders, including incontinence and frequent nightly urination, due to multifactor diseases. The overall goal is to establish temporary antidiuresis as an efficient new therapeutic strategy to improve health and quality of life. This will be based on extensive basic, clinical and industrial research of vasopressin-V_2-receptors (VP-V_2R) and kidney function. As necessary new drugs, short-acting VP-V_2R agonists will be developed. Lead compounds exist and test systems will be established to characterise the compounds at the molecular structural level and at the cellular and integrated level. After safety testing lead compounds will be used in initial clinical trials. Such a treatment will provide symptom relief for these very common life-disrupting disorders with improved health and life quail for this very large group of patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Single Cell Electroporation and DNA dynamics: from bulk to micro/nanofluidics' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Electroporation or electropermeabilization is the electrical disruption of a cell’s membrane to introduce foreign DNA, RNAs, drugs, proteins, or other therapies into the living cells. This technique is one of the most popular non-viral gene transfer methods for both in vitro and in vivo application. However, this method is suffering from several limitations such as: i) low transfection efficiency, ii) poor cell viability, and iii) random uptake. Multiple applications of electroporation in biotechnology and medicine rely on trial and error optimization of treatment conditions rather than knowledge of pores, dynamics and electrotransfer of DNA, due to the limited spatial and temporal resolution of traditional tools. More interesting, the phenomena behind electro-mediated membrane permeabilization to plasmid DNA (~4.5 kbp) have been shown to be significantly more complex than those for small molecules. Therefore, successful DNA electrotransfer into cells depends not only on cell permeabilization (or poration) but also on the way plasmid DNA interacts with the membrane and, once into the cell, migrates toward the nuclei.The main aim of this proposal to understand and control the transport of DNA in electroporation treatment such that stable, safe and efficient gene transfection can be achieved. Here I will use single molecule techniques (such as AFM, FRET, confocal and optical tweerers) with high spatio-temporal resolution to investigate the process of electroporation at different length (from bulk to micro/nano) and time scale (ranging from micro-seconds to hours). In addition, these unique tools will be integrated with novel micro/nanofluidics to investigate the electroporation and electrokinetic flow of DNA at micro/nano-scale.  I will observe all the processes in real t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Combined structural and electronic characterization of semiconductor nanowire devices on the atomic scale using scanning tunneling microscopy and spectroscopy' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Free-standing III-V semiconductor nanowires, with diameters of about 20 to 80 nm at a length of several µm, offer tremendous possibilities for application in photovoltaics, optoelectronics, information technology as well as life-science. Semiconductor nanowire devices are not only smaller than conventional structures and significantly power-saving, but can even exhibit qualitatively novel behavior. Due to the small size and the very large surface to bulk ratio, the nanowire surface has a crucial influence on the performance of the entire device.Up to now, the conductivity and other electric properties of single nanowire devices on one hand and the nanowire crystal and surface structure on the other hand could only be measured separately. Here, we will combine both approaches in a novel experimental setup, enabling us to achieve information on the atomic surface structure and local electronic properties of an individual nanowire as well as the global electric behavior of a device built by the same nanowire simultaneously. For this purpose, we will study single, individually contacted semiconductor nanowires using scanning tunneling microscopy and spectroscopy (STM), obtaining data on e.g. the chemical composition and atomic reconstruction of the nanowire surface as well as the local density of states and local variations of the band alignment. During these STM measurements, external source, drain and gate voltages can be applied to the nanowire device, revealing the complex interaction of the nanowire surface, local charge distribution, and global device performance like conductivity and other transport properties.