RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dual targeting of senescence and tumor immunity for cancer therapy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

We have previously demonstrated that cellular senescence opposes tumorigenesis thereby opening up new potential opportunities for cancer treatment. Senescence and tumor immunity in cancer are tightly interconnected. Tumor-infiltrating immune cells promote the clearance of senescent tumor cells thereby contributing to the tumor suppressive function of senescence. Moreover, T lymphocytes can drive senescence in cancers by secreting different cytokines in the tumor microenvironment. We have also recently reported that GR1+ myeloid cells antagonize treatment-induced senescence (TIS) and that compounds that block the tumor recruitment of GR1+ cells enhance TIS. Major objective of this proposal is to characterize the immune landscape of different prostate cancer mouse models in order to develop novel treatment modalities that combine pro-senescence compounds with immunotherapy. Using proteomics and bioinformatics approaches, we will assess how the genetic background of prostate tumors, shapes the tumor microenvironment and immune response during TIS. Next, we will define the mechanisms that regulate the recruitment and activation of myeloid derived suppressive cells, macrophages and B-lymphocytes in Pten deficient prostate tumors by focusing on a novel class of secreted factors identified in these tumors. We will also assess in vivo whether the secretome of tumor cells can transmit senescence to TILs and compounds that interfere with the secretome can prevent immunosenescence. Finally, we will develop monoclonal antibodies directed towards senescent tumors cells that we will use as diagnostic and therapeutic tools. These antibodies will be used as biomarkers to detect senescent tumor cells in prostate cancers and will be tested in pre-clinical trials to assess whether they im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Implications of heterogeneous confidence in beliefs for theories of entrepreneurship, economic cycles, and time consistency of monetary policy', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Summary of the project: The project investigates applications of a recent approach to decision making under uncertainty. The main idea is that individuals' preferences do not satisfy the completeness axiom. Then, individuals use a set of probability distributions instead of a single probability to compute expected utilities. The size of this set, how many distributions each individual considers, reflects different degrees of confidence in understanding the environment. This framework is important for two reasons. One can ask whether some conclusions of existing models are robust when economic agents lack confidence in beliefs. Second, a novel and realistic description of heterogeneity across individuals is possible. There is no a priori reason to assume lack of confidence is identical across individuals; some agents may have revious experience of a particular situation while others do not. This experience is reflected by higher confidence in beliefs Other agents may not have this experience to help them evaluate uncertain situations. The objective of the research is to provide a rigorous answer to the following questions. What motivates an entrepreneur's decision to invest in a particular project? What does this decision imply for economic fluctuations? How doe the monetary authority affect the understanding the public has of the economy?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Support for networks creation in the field of Global Change and ECOsystems - from idea through proposal submission and project managing till completion and successful audit' (ECONETUS).

assistant: **Innovation**

ECOnetus project aims to provide support for networks creation in the field of Global Change and Ecosystems in Europe and to establish strong cooperation between participants from Member and Associate Candidate Countries. This project's consortium consists of partners from: Poland, Lithuania (representatives of ACCs), the United Kingdom and Austria (representatives of MCs). In this project Poland and Lithuania will act as a bridge between ACCs and MCs while promotion of this project in MCs will be assured by other partners. Good relations with Contact Points from other ACC countries will ensure efficient project results dissemination.The project will actively contribute to the implementation, stimulation, encouragement and facilitation of the participation mainly in the research activities of this priority thematic area among potential RTD projects' participants (from research and industrial units). It also aims to assist all established consortia during a whole project's life" -from idea through proposal submission and project managing till completion and successful audit. At the beginning of the project participants from MCs and ACCs will have a possibility to get to know one another during brokerage meetings and create consortia (working groups), which will allow opening research groups from MCs to cooperate with participants from ACCs. Later on, established international working groups will have a chance to participate in workshops organized by ECOnetus and then create and consult their proposals with its Scientific Advisory Group and Assistance Group. It is expected that there will be RTD projects submitted by consortia established and assisted by ECOnetus in 6th FP and also in 7th FP. Another aim of the project is to better educate the Contact Points' experts from
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Modular Intelligent Hydraulics' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

HYDRONIT is a company established in 2003 whose core business focuses on research, development and production of smart modular hydraulic power packs and relevant components for the mobile industry, for which we strive for excellence. We operate in 50+ countries with daughter companies located in China, the UK and the US. Our passion for hydraulics power and our commitment with our customers let us reach €4 million turnover in 2015, 60% of which coming from exports (as of 2016Q2, we project 10% growth for 2016, which will let us achieve €4.4 million turnover).Hydronit has always pursued a full new concept of hydraulics consisting on building modular solutions that integrates all necessary pieces of knowledge (electric/electronics on top of hydraulics), removing the need to resort to multiple subcontracts to produce the final equipment. Following this philosophy, we have been developing MIDRAULICS, a programmable intelligent mini and micro power pack for the mobile industry (e.g. industrial, construction and agricultural vehicles and equipment). MIDRAULICS will provide our customers in the mobile application sector: 1. Full control  distribution of hydraulics (100% compared to conventional systems with no integrated control); 2. Total safety thanks to a better control of the solution components and power; 3. Huge energy saving, as a results of the following factors: 86% less material for wiring; 10 % electric power savings in on-off applications thanks to start stop features; 30% electric power savings in variable speed applications through use of Inverters and AC motors.4. Environmental friendliness, thanks to Metal reduction (no need for sensor housing) and Cable reduction (through use of wireless communications) Thanks to MIDRAULICS, we expect to generate about €6.87 m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Developing therapies for Nitric Oxide (NO) related neurodegeneration' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Nitric oxide (NO) is an essential signaling molecule for diverse physiological and disease processes.  The current paradigm of NO regulation focuses at the level of nitric oxide synthase (NOS). However, the respective unique or combined genetic deficiencies of the NOS isoforms exhibit relatively modest phenotypes in mice.  Moreover, approaches targeted at modulating NOS activities have not successfully translated into therapy.  All NOSs isoforms use arginine as the sole substrate for NO production and interestingly, only one enzyme in mammals- argininosuccinic acid lyase (ASL) synthesizes endogenous arginine.  In humans, ASL deficiency (ASLD) causes argininosuccinic aciduria, the second most common urea cycle disorder.  In stark contrast to other urea cycle disorders, patients with ASLD show systemic and chronic features even with good metabolic control.  We recently demonstrated a new structural requirement of ASL for maintenance of a NO synthetic complex necessary for generation of NO from both intracellular and extracellular sources of arginine.  Thus, in the absence of ASL, there is decreased NO signaling. Importantly, we were able to translate our findings in a clinical therapeutic human context by supplementing an ASA patient with NO donors and improving his cardiovascular and neurocognitive functions.  We now hypothesize that regulating ASL would allow us to characterize the cellular and molecular mechanisms underlying the NO flux at normal and pathological conditions, for therapeutic applications.Using a novel conditional knockout model of Asl, we are now uniquely positioned to dissect the cellular contribution of NO metabolism to different disease pathogenesis. As a proof of concept, we will start by dissecting NO metabolism in the central nervous system at hom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'WeSenseIT: Citizen Observatory of Water' (WESENSEIT) under Seventh Framework.

assistant: **Objectives**

WeSenseIt will develop a citizen-based observatory of water, which will allow citizens and communities to become active stakeholders in information capturing, evaluation and communication.We propose:(i) data collection: (a) a first “hard” layer consisting of low-cost, static and portable devices that sense and transfer water information when automatically monitored or when initiated by citizens from their mobile devices; (b) a second “soft” layer consisting of techniques to harness citizens’ Collective Intelligence, i.e. the information, experience and knowledge embodied within individuals and communities, both in terms of enabling direct messages to the authorities (with mobile-phone pictures, messages, etc.) and in terms of crowd-sourcing (e.g. by mining social networks like Twitter and Facebook, as well as bulletin boards, RSS feeds, etc.).(ii) the development of descriptive and predictive models and decision-making tools integrating sensor and citizen-based data; the data suppliers (physical sensors or people) are seen as nodes of an integrated heterogeneous data collection network which undergoes progressive multi-objective optimization and tuning.(iii) two-way feedback and exchange of environmental knowledge/experience between citizens and authorities for decision-making and governance within an e-collaboration framework ,enabling improved transparency, knowledge management, accountability and responsiveness, as well as facilitating participation in water management.We will test, experiment and demonstrate the citizen observatory of water in three different case studies in water management with civil protection agencies in UK, NL and Italy. The topic is the entire hydrologic cycle with a major focus on variables responsible for floods and drought occurrences.The p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Latin in Old Norse-Icelandic Manuscripts' (2007-2013).

assistant: **Innovation**

Dr. Jensson, a professor of comparative literature and classics at the University of Iceland, proposes to develop a comprehensive description of Latin letters in medieval Old Norse-Icelandic manuscripts at the Department of Scandinavian Research, University of Copenhagen. This entails a two-year Work Programme in Copenhagen to compile an analytical state-of-the-art XML database offering full informational coverage of Latin works, composed, copied, translated or otherwise utilized by Old Norse-Icelandic scribes. Few original texts in Latin are preserved in Old Norse-Icelandic manuscripts compared with the great number of Icelandic vernacular works. This seems to underlie a common but inaccurate assumption that medieval literacy in the area was radically exceptional in western and central Europe with respect to the use of Latin. But if one documents the number of known and lost original Latin works, references to the use of Latin in Iceland and Norway, Latin texts found in Old Norse-Icelandic manuscripts, vernacular translations of Latin works, lists of Latin books that were in the libraries of churches, monasteries and cathedral schools, and Latin sources identified in the vocabulary collection of the Dictionary of Old Norse Prose, a very different picture emerges of medieval Icelandic-Norwegian literacy and one that is much less exceptional with respect to the use of Latin. By compiling a database of XML-encoded documents related to Latinity which is compatible with and supplementary to the Dictionary of Old Norse Prose online (dataonp.hum.ku.dk) and the Online Electronic Catalog of Icelandic Manuscripts (handrit.org), two projects presently under construction at the Department in Copenhagen, the foundation of a new knowledge portal based on new insights will be laid. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Biofilm Alliance', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Infections by biofilm-forming microorganisms on indwelling medical devices such as catheters, prosthetic joints and internal fracture fixation devices pose a serious health threat. Overall, approximately 3% of all patients receiving such devices develop biofilm infections, with costs adding up to billions of Euro’s.Current strategies to combat biofilms are based on conventional antibiotics. They often fail because 1) biofilms are difficult to penetrate, 2) micro-organisms in biofilms are resistant to most  conventional antibiotics, 3) antibiotics cause release of pro-inflammatory microbial compounds, and 4) the locally available concentrations are too low.The aim of BALI is to disrupt biofilm formation  by a unique combination of Synthetic Antimicrobial Antibiofilm Peptides (SAAPs) with biofilm dispersing, microbicidal, and immune-orchestrating activity, incorporated in novel controlled release drug delivery formulations (PolyPid), for both prevention and treatment of biofilm infections.  The recently developed SAAP OP-145, already tested in humans, will be the first candidate.PolyPid, a unique polymer-lipid-based drug delivery platform will be tailored  for coatings allowing prolonged and pre-determined release rates of SAAPs, to ensure the required local concentrations over a desired period. The coatings will be optimized in vitro and subsequently in mice and rabbit studies to prevent and treat biofilm infection. Finally a phase 1 study in patients with bone fracture fixation devices will be performed.The novel SAAP-delivering PolyPid  formulations can control biofilms and allows for treatment and management of infections,  reducing infection rates of implanted medical devices. Patients relying on safe and effective medical devices thus will benefit strongly by reduct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The first blood test for the early detection and prognosis of Acute Myeloid Leukaemia' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Acute myeloid leukaemia (AML) accounts for about 25% of all leukaemia in the Western world. Its overall survival rate for 5 years is the lowest of all types of leukaemia (27%): above 60% of AML patients will succumb to the disease.  Currently, there is no method for early detection of AML. It is diagnosed based on the presence of blasts in bone marrow samples and must be treated immediately to avoid a near-future death. Due to this late detection, AML treatment is of low effectiveness. The aggressive and often fatal nature of AML makes it a priority for developing early and fast diagnostic and prognostic tools.  We have identified a new biomarker for the early detection and prognosis of AML. This biomarker is detected and quantified by our innovative In vitro Diagnostic Test (IVD), named Serostrat, via a fast, cheap and routinely clinical blood analysis. We own the exclusive exploitation rights of SeroStrat. SeroStrat specifically targets the AML biomarker in blood cells, discriminates between AML unfavourable risk patients and AML patients with intermediate risks; is low-invasive and painfulness (only requires a blood sample instead of bone marrow samples); is fast and non-expensive (it can be used routinely in clinics in blood samples analysis by Flow cytometry) and will permit risk groups (persons aged >65), AML new patients, and persons in remission to be monitored easily and accurately for signs of recurrence.  We are Leukos Biotech S.L. (Leukos), a Spanish spin-off company founded in 2015 from the prestigious Josep Carreras Leukaemia Research Institute.  Our goal is to enter fully into the biopharma sector, which will allow us to move to a business model which will create 50 new jobs and cumulative profits about € 22M by 2024.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Imoos' under Fifth Framework.

assistant: **Concept**

The main scientific objective of the meeting is to set up a forum that will enable the exchange of information between scientists studying oxidative and osmotic stress in different organisms. Indeed, few meetings bringing together people working on the molecular mechanisms underlying the stress response using different cell models are occurring at present, namely in Europe. This meeting will address the sensing of both stress challenges (osmotic and oxidative) as this issue remains an intriguing event. The signalling pathways have been disclosed, however the regulation associated with the stress response and the cross talk between the pathways still remains to be clarified.The cell adaptation to the changes in environmental conditions including change in the expression of specific genes and in enzymes activities will also be analysed. In this context the induction of similar genes and the activation of identical enzymes by the two stress agents indicates common defence mechanisms. However, the relevance of the common responses in different cell systems is still a matter of discussion and new approaches will be discussed, namely its importance in diseases and in biotechnology (eg. plant development, bioreactors).An integrative approach of the stress responses will be discussed in deep. he topics will be presented by selected 8 keynote speakers, covering:a) Oxidative stress response in bacteria, in yeast, in plants and in mammals, b) Osmotic stress in bacteria, in yeast, in plants and in mammals (see speakers name in the meeting programme). There will be two lectures, one covering an overview of common mechanisms of the stress response (D.Thiele, USA) and the role of kinases in different cell systems (S.Keyse, UK). In addition, 24 short talks (15 min) will be selected fro