RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'VISION-DMD - Phase 2 Clinical Trials of VBP15: An Innovative Steroid-like Intervention on Duchenne Muscular Dystrophy' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

VISION-DMD aims to advance clinical development of the orphan drug VBP15 as a new therapy to revolutionise care for all patients with Duchenne muscular dystrophy (DMD) by 2020, in line with IRDiRC goals. DMD is an incurable, rare muscle wasting disease; boys progressively weaken, lose ambulation and death occurs by early adulthood. Corticosteroids (CS) are widely recognised to increase muscle strength and delay disease progression but global acceptance as standard of care is very variable due to severe side effects. VBP15 is an innovative steroid-like drug designed to retain or better CS efficacy and improve membrane stabilization with reduced or no side effects. VBP15 will increase the therapeutic window to slow disease progression and improve quality of life and lifespan for all DMD patients. Building on positive preclinical and Phase 1 results funded by government grants and international patient groups and based on FDA and EMA advice, VISION-DMD proposes a Phase 2 registration directed clinical programme aimed at an affordable therapy: Phase 2a will study the safety and tolerability of ascending doses of VBP15 in ambulant DMD boys; Phase 2b will demonstrate the efficacy and safety of two doses of VBP15 in young ambulant DMD boys. Both studies will be followed by extension studies for long term safety and efficacy data collection leading to cumulative exposure of up to 2100 drug months. The project proposes the Time to Stand Test as a highly relevant and reliable primary endpoint. Innovative exploratory serum biomarkers and novel wide scale MRI techniques will be used to investigate the VBP15 pharmacodynamics and the effect on muscle cellular pathology. VBP15 will meet the unmet need for better treatment for DMD with widespread acceptance and potentially be used in c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A New EU Framework for an Ecological AI' (EcoAI), addressing dissemination and exploitation.

assistant: **Impact**

EcoAI aims at creating a new regulatory framework for an ecological AI to align AI development with sustainability, bridging gaps in scholarly efforts but also providing policy suggestions to EU institutions, facilitating evidence-based decision making, and ensuring that the proposed regulatory framework is a blueprint both for technology regulation more broadly, and for non-EU Countries (Brazil will be a case study in this respect). Other Countries’ legislation could also be influenced by signing cooperation agreement on the sustainable use of AI. It is for this reason that EcoAI aims also at drafting a proposal for an agreement between the EU and Brazil to strengthen their cooperation in addressing the global challenge of climate change using AI. To build this new framework and the proposal for an agreement on AI for the public good between the EU and Brazil, I will develop and test in intersectoral practical environments and in two different legal frameworks, i.e. EU and Brazil, the innovative concept of “Ecological AI”: the possibility of using AI in an “ecological” way for the public good, in accordance with the fundamental rights enshrined in the Charter of Fundamental Rights of the EU . To reach this objective, EcoAI has a strong interdisciplinary approach, bridging law, computer science, and political sciences, with some exposure to sociology, taking into primary account the needs of the public and private sector, and those of citizens, who are the category mainly exposed to the negative effects of climate change. To ensure the successful implementation of these project goals, to gain new skills and competences, and to identify solutions to two of the biggest challenges of our time, the University of Siena (UNISI) and the University of San Paolo (USP) are the mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'An Innovative ICT Solution for Providing Bespoke Safety and Health Training to Workers in the Construction and Transportation Sectors.' (SEEABLE) under Horizon 2020.

assistant: **Objectives**

An ICT solution for repurposing digital data available from Building Information Modelling (BIM) in order to improve Safety & Health (S&H) training and implementation. Every year, thousands are fatally injured and millions are seriously injured in accidents occurring in the workplace. The risk to workers is significantly higher in the construction and transportation sectors.BIM captures all digital data relevant to a building or piece of infrastructure over its lifetime. The use of BIM is becoming mandatory for public procurement projects in Europe and will generate a wealth of digital data. This presents a major opportunity for disruptive business ideas and we have identified the possibility to repurpose this data so that we can provide interactive and context-relevant S&H training via 3D applications.We, Severn Partnership, want to carry out a feasibility study around our concept for repurposing data from BIM. We will develop an application to deliver S&H training to railway workers. It will employ pedagogic strategies in a games environment to demonstrate enhanced learning. We will test it in a classroom environment with real learners and benchmark it against current methods of teaching (presentations, course notes, Q&A). The feasibility study will explore the market landscape across different sectors utilising BIM, especially within construction and transportation. A survey of executives from industries in these sectors will identify operational requirements. This will aid the creation of an exploitation strategy and business plan.The overall aim is to develop a new ICT service that improves the effectiveness of S&H training and ultimately saves lives by preventing accidents in the workplace.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Digital Network Management Services' in the context of a Horizon 2020 call.

assistant: **Objectives**

Project PJ09, Digital Network Management Services is focusing on improvement of the network traffic prediction for all DCB (Demand Capacity Balancing) actors, dynamic airspace configurations, integrated network management and ATC planning (INAP) and collaborative network performance management.  This project is structured along 3 solutions:  Solution 44 Dynamic Airspace Configurations (DAC) will address the user acceptability and operational feasibility of the proposed DAC solutions and it will focus on integration of the DAC with DCB. Solution 45 Enhanced Network Traffic Prediction and shared complexity representation aims to develop the multi-layer traffic prediction model improving the forecast in pre-tactical, early D day, tactical and execution time horizons. Solution 49 will validate an operational states prediction algorithm to anticipate the performance degradation in identified areas within the network. It will also validate the transition from local to regional measures in critical state.


**Keywords:** ATM Network Management NM DCB DAC INAP
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Partial Ionisation: Two-Fluid Approach'.

assistant: **Objectives**

PI2FA proposal’s overarching aim is to make a major breakthrough in our understanding of the magnetised solar chromosphere under a novel frame of a multi-fluid plasma theory. Future large-aperture solar telescopes, EST and DKIST, will have among their primary focus observations of chromospheric magnetic fields. The correct interpretation of solar data requires sophisticated theories. The solar atmosphere is made of strongly stratified, weakly ionised and not completely collisionally coupled plasma. In the previous PI’s ERC SPIA project we opened a new research line and performed systematic investigations of non-ideal effects due to neutrals in the solar plasma. To build the complexity step by step, we advanced a single-fluid formalism, best valid for a strongly collisionally coupled case. Nevertheless, a multi-fluid treatment is essential for the weakly coupled chromosphere because the processes of the energy transport and conversion happen at nearly collisional scales. Now it is the right moment to take advantage and consolidate the experience gained in the SPIA project and to bring our research to a new level of challenge. The ambition of the PI2FA proposal is to create and apply tools for multi-dimensional modelling of the solar chromosphere under a precise two-fluid multi-species approach. In the recent few years it has been repeatedly demonstrated that processes related to non-ideal plasma behaviour due to neutrals may be the key to solve the problem of chromospheric heating and dynamics. PI2FA project will make progress in the following questions: determination of chromospheric heating mechanisms; understanding destabilization mechanisms of prominences related to neutrals, and creation of multi-dimensional two-fluid models of the solar chromosphere. These models w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Unveiling the mitochondrial role of DNA2, a human helicase-nuclease causing mtDNA deletion associated syndrome.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Multiple deletions in mtDNA give rise to a variety of neuromuscular symptoms, often associated with genetic inherited disorders and aging and they have been reported in patients with neurodegenerative diseases, such as Parkinson’s and Alzheimer’s diseases. In spite of its medical importance, not much is yet known about the mechanisms by which mtDNA deletions are formed. Progressive external ophtalmoplegia (PEO) is one of the conditions characterized by the accumulation of mtDNA deletions. This disease is caused by mutations in components of the mtDNA replication machinery, like the DNA polymerase γ (POLγ) and the replicative helicase TWINKLE. Recently, also the helicase-nuclease DNA2 has been found mutated in patients affected by this disorder. The precise function of human DNA2 (hDNA2) has remained elusive. hDNA2 localizes to mitochondria and has the biochemical properties to process four-stranded DNA structure (G-quadruplexes). Interestingly, G-quadruplex DNA associates with mtDNA deletions formation in human diseases. To dissect the mitochondrial role of hDNA2, I will focus on the mechanism of hDNA2 recruitment to mtDNA. Then I will address the role of DNA2 in mitochondria metabolism and in G-quadruplexes mtDNA metabolism and I will characterize the consequences of disease-associated mutations in DNA2 gene. I will employ a range of in vitro (based on recombinant protein) and in vivo (inducible cell systems and yeast model).The clarification of the hDNA2 mitochondrial biological function will help to elucidate the mechanism by which mtDNA deletions are formed in mitochondrial disorders. Moreover, MITOQUAD project will lead to a deeper understanding of how mtDNA integrity is maintained, a relevant question for understanding the early development and progress of a large
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Foundation of Statistical Inference: Applications in the Medical and Social Sciences in Industry and the Interface with Computer Science' (1998-2002).

assistant: **Innovation**

Statistical Sciences has seen a tremendous growth and development in theory and methodology. Advent of computers has facilitated the use of modern statistics in all branches of science, making statistics truly interdisciplinary, strongly rooted in the medical, Social, Engineering and Natural Sciences. At the Same time the abundance of software and methods available to users brought to light the critical issues a model, or which methodology is appropriate, given the data and problem. Indeed, Mathematical Statisticians have been moving ahead, studying the appropriateness of models and methodologies to various types of data and to the decision- theoretic framework of the annalyses. The main goal of the conference is to help bridge the gap between theory and application. It seems that this gap is especially wide in the European (and Israeli) Statistical community and probably less so in the USA. For this purpose we invited several leading American Statisticians, whose work pertains to the interface between theory and application, to interact with EC Statisticians and especially with young researchers.Another wide gap that the proposed conference hopes to help bridge is that between Bayesian and Frequents Paradigm, both having a strong bearing on applications. Thus, the objectives are to bring together experts from industry and academia, to provide a forum for collaborative efforts and encourage interdisciplinary exchanges and to provide a meeting place for young and established statisticians. We believe that the best way to achieve the above-mentioned goals is by having tutorial sessions and lectures by leading experts. This type of communication among scientists of different convictions and among them and the young researchers will be of great value to Member and Associate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Self-assembly of synthetic nuclei: key modules for semibiotic chemosynthetic systems' (NEONUCLEI).

assistant: **Innovation**

NEONUCLEI will develop transcription-competent synthetic analogues of cell nuclei. These particles, termed neonuclei, will be obtained through self-assembly/organisation in mixtures of DNA, macromolecules (or nanoparticles), and lipids. The composition o f the neonuclei will be chosen to produce particles with internal nano-architectures capable of sustaining gene transcription upon the addition of transcription factors. These design of the static architectures of the neonuclei and their dynamic propert ies will be guided by observations on real nuclei. The DNA of the neonuclei will contain a gene cluster (or tandem repeats of the same gene). The genes will be separated by sequences designed to induce DNA compaction in response to specific chemical or p hysical stimuli. This will be exploited to establish non-biological control over the transcription of parts, or all, of the DNA. These control sequences offer the opportunity for multiple transcription control strategies and provide the capability of im plementing temporally co-ordinated synthesis of multiple gene products. Neonuclei represent a key enabling step in the realisation of semi-biotic systems; these are systems and devices that combine synthetic non-natural functional systems with systems o f biological origin. The neonuclei will be integrated with biological systems, or with isolated components, to produce novel semi-biotic devices capable of the controlled in situ synthesis of complex bio-molecules on demand.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'ellpha.io: accelerate bias tackle and commercial footprint'.

assistant: **Concept**

Ellpha is a French company founded in June 2018 by two women founders : Stephanie Creff (CEO) and Brigitte Ricou Bellan (advisor). They were  joined at the end of 2021 by Cyrille Duverne, COO.Ellpha’s  vision is to create a fairer, more diverse world, using data and smart technology.Ellpha’s goal is to empower people detecting and acting on bias to create a better world. ellpha.io wants to drive results fast, when progress on diversity, equity and inclusion has been slowly incremented.Ellpha is a Social Science model designed into an AI. The DeepTech innovation resides in the AI bias detection engineTM. It offers unprecedented ability to uncover and surface hidden bias & stereotypes in real time and across growing data sets.The company differs from its competitors because it addresses the full talent flywheel, it is agnostic and pure player and it is designed to improve existing tools and talent management processes. Ellpha tackles root cause not symptoms ; it offers a scalable and dynamic solution and is not looking for neutrality but for diversity and contextualization.To date, ellpha.io offers a first commercial version of its solution, Talentuum, and of its “AI bias detection engineTM. It provides all managers with live coaching to avoid potential bias risks & with opportunities to self-reflect and amend their content. It also provides HR leaders with aggregated insights and analytics providing a picture of potential bias across segments and groups.Ellpha’s challenge now relies on deepening its high-tech solution and accelerating its commercial development. Being awarded by the Women Tech EU program would help the company to overcome some of its clients challenges : easing the appropriation of the solution by the development of a web based onboarding and trial packa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Fuel INjector Coking and Autoxidation Prediction'.

assistant: **Concept**

The aim of this project is to develop a robust theoretical framework to allow the modelling of the build-up of surface carbonaceous deposits in jet fuel injection systems so that fuel injectors for advanced engines such as the VHBR may be designed with an acceptable maintenance frequency and their life span predicted. Given the high heat sink requirement on aviation fuel in geared turbofan architecture, the prediction capability developed within this proposal is essential to a rapid and low cost development of VHBR, lean burn fuel injector systems.The project team consisting of the Low Carbon Combustion Centre, the Department of Chemistry and the Centre for Advanced Manufacturing in the University of Sheffield will conduct a three-year programme to develop the understanding of fuel injector coking through a combination of experimentation and simulations of various scales and complexities. The proposed programme builds on the significant expertise within the core team.The objectives of the Proposal are:1.      Construction of an updated and robust autoxidation kinetic mechanism for surrogate hydrocarbons representative of an approved aviation fuel.2.      Validation of the detailed mechanism with autoxidation results for real fuel and surrogate hydrocarbon obtained in a near isothermal plug flow reactor over a range of temperatures. Followed by the automated mechanism reduction through species lumping and reaction grouping.3.      Validation of mathematical model with respect to the experimental results obtained from low TRL level experiments and parameter optimisation4.      Experimental investigation of surface deposition in a simulated burner feed arm using “Aviation Fuel Thermal Stability Test Unit” and assess impact of surface roughness in a representative fuel inje