RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bacterial effector secretion: Function and Architecture of the Type 3 Secretion System' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Bacterial pathogens secrete effector proteins to manipulate host cells during infection. In Gram-negative bacteria the conserved type 3 secretion system (T3SS) delivers effector proteins to the host cell in a spatiotemporal manner. Although major T3SS constituting components were identified the function of this macromolecular complex remains elusive which is why the transport mechanism is not understood yet.Here, I present my research proposal of the functional and structural analysis of the T3SS with respect to the effector transport dynamics. The proposal is divided in three sections addressing the T3SS architecture, the cytosolic mechanism preceding effector molecule release and the molecular mechanisms of secretion regulation.Research focus of the first section is on the 3-dimensional structural analysis of isolated T3SS. The proposed studies should help detecting structural features related to the effector transport. A combination of electron microscopy (EM) and mass spectrometry is proposed to analyze the structure and surface properties of the transport channel together with bound effector molecule. I am also planning localization of bound lipids as well as to detect lipid induced structural changes in the T3SS by EM. Characterization of cytosolic processes, preceding the translocation is the focus of the second section. Effector molecule targeting, insertion into the T3SS channel and the chaperone function will be studied using a combination of biochemical and biophysical techniques.Finally, I propose experiments to analyze the T3SS regulation. Here, the research focus is on host signal reception and downstream posttranslational modifications inside bacteria as well as on conformational dynamics of the T3SS needle tip complex.The overall goal of the proposed wor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Islamisation of Anatolia, c. 1100-1500' (ISLAMANATOLIA), addressing dissemination and exploitation.

assistant: **Impact**

This project studies the transformation of Anatolia from a Christian to a majority Muslim society over the period c. 1100 to 1500AD. Whereas previous research has concentrated almost exclusively on conversion, this study also emphasises the importance of acculturation to Islam, and thus seeks to understand the processes through which Islamic culture took root among the recently converted Turkish as well as Christian populations. Very little is known of the spread of Islam in the region, and the nature both of the religion and culture of Muslim Anatolia islittle understood, even though these transformations gave birth to the Ottoman Empire, which played a vital role in shaping European history, and ultimately Turkey itself which remains a dynamic if much debated force in the modern world. This project examines the formation ofAnatolian Islamic society through the extensive but largely unstudied literary evidence it has bequeathed us in the form of numerous Arabic, Persian and Turkish manuscripts. Despite work on individual texts, the contours of this literature as a whole are largely unknown, and many works remained unpublished. This project will create a publicly accessible database of the extant manuscripts produced and circulated in Anatolia during the formative period of Islamisation from the twelfth to the beginning of the sixteenth century, containing information on their contents as well as details of place and date of copying, patronage, and authorship. This will also represent a major contribution to the study of the literatures of Arabic, Persian and especially Turkish by providing a repository of reliable information about the early manuscript heritage of the region. The database's codicological information will be linked to mapping software, providing for the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Europen Nuclear Education Network Training Schemes' to be submitted under Seventh Framework.

assistant: **Abstract**

The project covers the structuring, organisation, coordination and implementation of training schemes in cooperation with local, national and international training organisations, to provide training to professionals active in nuclear organisations or their contractors and subcontractors. The training schemes provide a portfolio of courses, training sessions, seminars and workshops for continuous learning, for upgrading knowledge and developing skills. The training schemes allow the individual to acquire qualifications and skills, as required by specific positions in the nuclear sector, which will be documented in a training passport. The essence of such passport is to be recognised within the EU by the whole nuclear sector, which provides mobility to the individual looking for employment and an EU wide recruitment field for the nuclear employers. The recognition is subject to qualification and validation of the training courses according to a set of commonly agreed criteria, which can be ratified by law or established on a consensus basis within a network. The training schemes cover profiles for each of the following: - the basic training in selected nuclear topics of non nuclear engineers and personnel of nuclear facilities contractors and subcontractors;  - the technical training for the design and construction challenges of GEN III plants, and the design of GEN IV plants. The training schemes consists of three distinct phases: - Courses, seminars, learning, scientific and technical visits, case studies; - Participation to selected activities within the scope of the training in different organisations; - Autonomous conduction of activities within the scope of the training under supervision of a mentor in one or in different organisations The first phase can be provid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'EUROPEAN CHART HUB OPERATIONS', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The purpose of ECHO is to provide an automated, integrated system for the collection, storage, management and distribution to end users of electronic sea charts and updates. The system will include basic geographic data collection and distribution, together with interfaces to non-geographic sub-systems, such as accounting and product management, to make for a seamless, end-to-end user support operation. It will form an architectural basis for a full commercial service involving additional European hydrographic offices and a growing end-user community. Guidelines will be provided for future network users and suppliers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European Partnership on Innovative SMEs', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

WHO: The proposal involves 40 National Funding Authorities and/or Agencies under the Umbrella of Eureka and is coordinated by the Eureka Secretariat in Brussels. Founded in 1985, Eureka is a global network, with 48 Member States plus the European Commission. It includes nearly all countries of the European continent as well as international members like Israel, Turkey, Korea, Canada, Singapore, South Africa, Argentina and Chile. The Consortium also benefits from the fact that is has successfully run the Eurostars 1 and 2 programs.WHAT: The proposed European Partnership on Innovative SMEs will comprise two main instruments (Eurostars 3 and Innowwide) as well as measures to connect to existing EU programs, initiatives and other European partnerships. EUROSTARS 3 (E*3) is an instrument that supports the international cooperation of SMEs in the field of non-military collaborative innovation projects. An E*3 project consortium must be composed of at least 2 independent entities from at least two participating countries and must be led by an innovative SME. The E*3 instrument benefits from accompanying measures that strengthen SMEs’ ability to access foreign markets like the INNOWWIDE instrument, which has already been piloted with the support of some Eureka network members in recent years. WHY: The biggest challenges for innovative SMEs are the access to international cooperation and to enter international markets as well the ability to receive funding. E*3 through its coordination of national innovation programs will in addition support the further development of a European Research Area.HOW: The Eureka Secretariat will organize two joint transnational calls per year for E*3 and one call per year for Innowwide. National Innovation Agencies actively support the implementatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ancient Iran: a Social Archaeology' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The objective is to conduct cutting-edge research into the archaeology of Iran, culminating in the publication of a state-of-the-art analytical study in the form of a book entitled 'Ancient Iran: a Social Archaeology'. The project will bring together Iran's leading archaeologist, Dr Hassan Fazeli, with a prominent UK researcher, Professor Roger Matthews, who will jointly carry out the research using the first-class facilities at UCL for the first 24 months of the project. The final 12 months of the project will be spent in translation and publication preparation of a Farsi edition of the book.The archaeology of Iran has been understudied in recent decades and a major objective here is to situate the rich Iranian evidence in the context of contemporary archaeological theory. Major research issues will include the articulation of a model for a social archaeology of Iran, the development of Iranian archaeology as a discipline, the early prehistoric occupation of Iran, the development of settled, farming communities from 10,000 BCE, Iran's role in the rise of the world's first urban, literate societies, and Iran in the first world empires of the Iron Age.The research will be highly innovative in that no similar study has ever been conducted on the archaeology of Iran, and also very timely in that it will develop wider academic and public understanding and appreciation of Iran at a time when they are much needed.  The researcher will benefit immensely from an extended period in the European Research Area, and will succeed in bringing his broad and detailed knowledge of the archaeology of Iran fully into the European arena, thus at the same time enhancing his own skills and expertise while raising the global attainment of Europe within the field of Iranian studies.The researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Adolescent Precursors to Psychiatric Disorders – Learing from Analysis of User-Service Engagement' (APPLAUSE).

assistant: **Concept**

APPLAUSE’s aim is to produce a body of evidence that illustrates how young people with mental health problems currently interact with both formal mental health services and informal social and familial support structures. Careful analysis of data gathered in the UK and Brazil will allow formulation of globally relevant insights into mental health care delivery for young people, which will be presented internationally as a resource for future health care service design.APPLAUSE will allow the collection of an important data set that does not currently exist in this field, and will look to other disciplines for innovative approaches to data analysis. Whist standard analysis may allow for snapshots of health service use, using innovative life course methods will allow us to to characterise patterns of complete service use of each individual participant’s experience of accessing mental health care and social support.Adolescence is a critical period in mental health development, which has been largely neglected by public health efforts. Psychiatric disorders rank as the primary cause of disability among individuals aged 10-24 years, worldwide. Moreover, many health risk behaviours emerge during adolescence and 70% of adult psychiatric disorders are preceded by mental health problems during adolescent years. However, delays to receiving care for psychiatric disorders, following disorder onset, avreage more than ten years and little is known about factors which impede access to and continuity of care among young people with mental health problems. APPLAUSE will analyse current access models, reports of individual experiences of positive and negative interactions with health care services and the culturally embedded social factors that impact on such access. Addressing this com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Attend-to-learn and learn-to-attend with neuromorphic, analogue VLSI' (ALAVLSI).

assistant: **Concept**

A system for memory-guided perception on the basis of neuromorphic VLSI technology will be built. It will combine multiple VLSI chips with a unique communication infrastructure (address-event-representation, AER) that provides a technical realisation of biological many-to-many connectivity. The aim of the system is to perform classification and match-to-sample tasks in real time on selected types of natural images and sounds. The system will emulate the mutually beneficial interaction between attention and learning found in humans: attention accelerates learning ('attend-to-learn') and learning guides attention ('learn-to-attend'). To verify these and other emergent behaviours, synthetic stimuli and benchmark tests adapted from visual and auditory psychophysics will be used. Thus it will be possible to directly compare at every stage system and human performance. A system for memory-guided perception on the basis of neuromorphic VLSI technology will be built. It will combine multiple VLSI chips with a unique communication infrastructure (address-event-representation, AER) that provides a technical realisation of biological many-to-many connectivity. The aim of the system is to perform classification and match-to-sample tasks in real time on selected types of natural images and sounds. The system will emulate the mutually beneficial interaction between attention and learning found in humans: attention accelerates learning ('attend-to-learn') and learning guides attention ('learn-to-attend'). To verify these and other emergent behaviours, synthetic stimuli and benchmark tests adapted from visual and auditory psychophysics will be used. Thus it will be possible to directly compare at every stage system and human performance.OBJECTIVES- Design visual and auditory feature sp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Scenario simulations of the changing Black Sea ecosystem' (SIMSEA).

assistant: **Innovation**

Marine modeling at JRC provides a tool to examine the present and future state of the marine ecosystem and can inform and support a variety of EU policies including the Marine Strategy Framework Directive. The Black Sea has suffered from severe ecological changes since the 1970s due to concurent effects of intense eutrophication, overfishing, outburst of  gelatinous carnivores and natural climatic variations. The main purpose of the project is therefore to implement an advanced ecosystem model for the complex Black Sea ecosystem based on the validated JRC hydrodynamic model to generate future scenario simulations considering different policy options and climate change scenarios. The data generated from these scenario simulations will be thoroughly analysed using state of the art statistical methods like singular spectrum analysis and breakpoint detection methods. The results of this work will be broadly disseminated not only to the scientific community but it will be ensured that various groups, public bodies and agencies (e.g. the Commission on the Protection of the Black Sea Against Pollution, etc.), outside of academia can and will utilise the knowledge produced.


**Keywords:** Ecosystem modelling, future scenarios, anthropogenic drivers, policy options
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'DeepNOE: Leveraging deep learning for protein structure solving at ultra-high resolution on the basis of NMR measurements with exact nuclear Overhauser enhancement' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Nuclear Magnetic Resonance (NMR) spectroscopy is one of the leading techniques for protein structure analysis. In contrast to other methods, NMR spectroscopy allows the measurement of the dynamics and structure of a protein under nearly physiological conditions, without the need for crystallization or freezing of a sample. Recent studies on exact Nuclear Overhauser enhancements (eNOEs), carried out in the laboratory of the host professor, have enabled distance measurements in proteins by NMR with accuracy of 0.1 Å. This allows to determine structures in solution and in living cells with unprecedented resolution.This biophysical achievement creates an outstanding opportunity for a computer scientist (the fellow candidate) to develop the first-of-its-kind model/algorithm that automatically transforms raw NMR measurements into high-resolution protein structures that reveal multiple simultaneously populated conformational states in atomic detail. This problem will be tackled with the use of deep learning (DL), a novel field in machine learning that has emerged after 2010 and has revolutionized data science and artificial intelligence.The project is divided into 3 parts. First, it is planned to investigate recent advances in DL to derive a model that extracts visual information from 2D and 3D NMR spectra. Afterwards, the proposed model will be integrated into CYANA to formulate a hierarchical DL/optimization routine, which automates all steps of protein structure solving. Finally, it is planned to explore the possibility of calculating protein structures directly from NOESY spectra, which constitutes a new protocol for protein structure solving by NMR spectroscopy. Summing up, the proposed DL approach has the potential to reduce the time required to solve proteins with NMR f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Systems Analysis of The Physiological Determinants of Phage Infection Dynamics', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Bacteriophages (phages) are viruses that infect and kill bacteria, playing a crucial role in shaping microbial communities. They are also emerging as precision tools for combating antibiotic-resistant bacteria, targeted biocontrol, and microbiome modulation.As obligate parasites, phages rely on the physiological state of their bacterial hosts to progress through infection stages. However, the mechanisms by which host physiology affects the success of phage infection within cells and how host variability impacts phage effectiveness in eradicating bacterial populations remain poorly understood. This knowledge gap limits our ability to predict phage performance across environments and engineer them for reliable use.Progress has been hindered by the lack of tools to link host cell physiology to phage infection dynamics and to connect single-cell variability to population-level outcomes. To address this, we have developed innovative methodologies, including a high-throughput imaging system for real-time tracking of phage infection progression within individual infected cells and the microCOSM platform, which integrates single-cell responses with population-level dynamics. Using these systems, combined with data-driven models and model-guided experiments, we will address three key questions:How do host physiological factors, such as metabolism and stress responses, govern phage infection success and progression at the single-cell level?How does variability in host cell physiology shape phage efficacy at the population level, and when do phage-tolerant subpopulations emerge?How do changes in the physical and biochemical nature of the host’s environment affect phage efficacy and how can we leverage physiological perturbations to steer infection outcome?This study will uncover t