RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Creation of a distributed European Magnetic Field Laboratory' in the context of a Seventh Framework call.

assistant: **Objectives**

The Radboud University Nijmegen, operating the High Field Magnet laboratory (HFML, for continuous magnetic fields), the Forschungszentrum Dresden-Rossendorf, operating the Hochfeld-Magnetlabor Dresden (HLD, for pulsed magnetic fields), and the Conseil National de la Recherche Scientifique, operating the Laboratoire National de Champs Magnétiques Intenses in Grenoble and Toulouse (LNCMI-G for continuous and LNCMI-T for pulsed magnetic fields), undertake a study how to organize and operate, under one umbrella, the European Magnetic Field Laboratory (EMFL).This study will investigate all legal, financial, organisatorial and employment related issues, and formulate a document for the founding agreement of the EMFL of the 3 partners, or any other stakeholders that may be identified.Different work packages will provide studies of the feasibility and cost of all the proposed investments in the new EMFL, and develop the in-house knowledge base for the investments, and harmonize experimental capabilities at the infrastructures. A web page and material will be developed  for communication with the user community and the public. The coupling of high magnetic fields with advanced light sources will be investigated and how joint operation of different infrastructures can be organised, and a future roadmap for EMFL established.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Therapeutic molecules for modulation of ligand-receptor mediated apoptosis' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Apoptosis is a fundamental process in the development and homeostasis of multicultural organisms. Deregulation of apoptosis, however, can result in disease pathogenesis. Examples are cancer; autoimmune disease, neurodegenerative disease and organ transplant dysfunction. The concept of apoptosis modulation allows for novel therapeutics. Our proposal exploits molecular evolution and computational techniques to design novel therapeutic protein/ peptides molecules that modulate apoptosis signalling pathways at the TNF receptor-receptor family interface. Agonists or antagonists that interact at this interface will be mutants of native proteins, such as TRAIL. Alternatively, minimised de novo binding proteins will contain receptor or receptor binding domains fused to, or incorporated onto a stable turmeric scaffold. We expect to develop a general strategy for rapid design and construction of algometric proteins/peptides therapeutics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'POROus media: Life and dEath of their wAves and Flames'.

assistant: **Objectives**

Turbulent combustion of fossil fuel remains an important source of energy creation and propulsion worldwide, generating pollutant emissions endangering both human health and climate. A major factor inhibiting the mitigation of emissions pertains to combustion instabilities, i.e.: large pressure oscillations resulting from a coupling between unsteady combustion and pressure waves. Carrying out the combustion within porous inert media holds great promise for lean combustion, owing notably to a strong heat recirculation effect occurring inside them. Despite the recognition that porous materials are natural wave absorbers, very little has been studied so far regarding the potential synergy between combustion instabilities and porous media. POROLEAF aims to pioneer the field of research residing at the intersection between the disciplines of waves, turbulent combustion, and porous media. A new set of scientific challenges will be introduced, related to the complex flow physics involved in porous media combustion, as well as the difficulty of accessing the physical fields within the pore matrix. To tackle these challenges, I will build on the skills developed during my thesis in the characterization of porous media microstructure, as well as recent advances in 3D printing technology for heat resistant materials, to create porous samples allowing optical access. This will pioneer the way for a new set of state-of-the-art experiments. I aim to leverage decades of previous work in combustion instabilities and focus on the new behaviors introduced by porous media. In particular, the effects of turbulence, entropy, vaporization, and flame dynamics will need to be re-evaluated in light of porous media interactions. The improved knowledge of these principles will enable unprecedente
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deep multiplexed epigenetic profiling of plasma cell-free nucleosomes for early cancer diagnostics' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Over recent years, cancer diagnostics based on cell-free DNA (cfDNA) in liquid biopsies demonstrated great promise in guiding treatment and screening for recurrent diseases. Current diagnostic strategies are mainly based on the analyses of DNA mutations, fragment length or DNA methylation status. However, these strategies do not provide a universal approach for cancer identification, are costly and labour intensive, and generally fall short in detecting cancer at early tumorigenic stages or minimal residual disease. An underexplored field, is the development of diagnostic applications based on histone post-translational modifications (PTMs). The strategy to harness these epigenetic signatures to identify cell-of-origin is potentially superior over state-of-the art methods because it offers targeted and multiplexed amplifications of exclusively informative genomic regions (i.e. promoters and enhancers). Such strategies are cost-effective and display much increased sensitivity over existing methods in their accuracy in e.g. early cancer diagnoses, relapse detection or screenings. Unfortunately, the development of this field is hampered by a lack of methods that are sensitive enough to detect multilayered histone PTM-signatures in samples with limited material such as blood plasma. This proposal describes our plan to implement two new strategies, for ultra-sensitive detection of multi-layered histone PTMs signatures in blood plasma. Our proposal outlines 1) a research plan for the implementation and optimization of these strategies to profile histone PTM profiles in plasma of healthy and patient material to determine the diagnostic potential of the method and 2) develop a market strategy and navigate product development opportunities for commercialization of the method. Su
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A new model for study relationship between pluripotency and tumorogenesis: molecular insights from basal chordates' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The potential formation of teratoma/teratocarcinoma from pluripotent stem cells represents one the main obstacles to safe use stem cell-based regenerative therapy. The gene network that regulates the stem cell tumoreginicity is still largely unknown. In this study we use as model the chordate Botryllus schlosseri (Ascidiacea), wherein through a process known as vascular budding, an adult is regenerated from pluripotent cells in a sequence of morphologically abnormal developmental stages which pass through a teratoma structure. The teratoma maintains a population of cells that preserve their pluripotency and eventually re-gain positional identity and differentiate “correctly” into a functional body. In this proposed project we take advantage of this in vivo phenomenon to explore the molecular bases regulating the equilibrium between pluripotency and tumorigenicity. We propose two complementary approaches: (1) To undertake unbiased high-throughout gene screening in order to define the trascriptome implicated in the vascular budding (2) to target candidate genes involved in endomesoderm specification and characterize their spatio-temporal patterns of expression and test their functions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel strategies for the prevention and control of persistent infections' (NOPERSIST).

assistant: **Innovation**

Persistent infections such as HIV, tuberculosis´(TB) in humans and para-tuberculosis (ParaTB)-, mycoplasma- and Haemophilus-infections in farm animals are global health problems of immense social and economic importance . HIV-1 affects about 40 million people and M. tuberculosis infection is even higher world-wide. Co-infection with M. tuberculosis is estimated in about one-third of HIV-1 infected subjects. Globally, there are more than 14 million persons dually infected with TB and HIV. Drug resistance to HIV-treatment and appearance of multiple-drug resistance (MDR) and off late of Extra-Drug Resistance (XDR) strains of M. tuberculosis , the causative agent of human TB is steadily leading to a hopeless situation as far as therapy is concerned. To make things worse, there is no effective vaccine available against the persistent infections addresses in this proposal. The four SME members of this consortium with complimentary areas of research and business activities, LIONEX (in TB), Prionics (in ParaTB) , Vichem (in HIV) and IVD (in pig infections) are dedicated to solving the problems of the persistent infections mentioned above by employing novel strategies of product development for diagnosis, prevention and control of these global diseases by outsourcing demanding but feasible work to internationally known research organisations (RTDP) with highly positive track record. The SMEs alone cannot perform the outsourced work but shall validate and exploit the results provided by the RTDPs. Our novel but realistic objectives are: 1. To develop new drug candidates for drug resistant persistent infections (HIV and TB) 2. To identify and isolate novel antigens for the diagnosis of TB, ParaTB and infections in pigs 3. To identify antigens suitable for vaccine development for t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Apolipoprotein E: Health and disease marker in Europe' (1994-1998).

assistant: **Concept**

1. To determine the factors affecting interindividual variation in apo E plasma concentration, in particular the role of apo E genetic polyrnorphism 2. To establish apo E genotype related reference ranges for plasma apo E concentration 3. To study the distribution of apo E genotype / apo E plasma concentration across different European populations4. To study, in case-control studies, the role of apo E plasma concentration together with apo E genotype as risk factors for: (i) CAD, (ii) ADThere is now much evidence implicating apolipoprotein E (apo E) in the pathogenesis of CAD and AD. The apo E gene is polymorphic with 3 common alleles (2, (3 and (4. The (4 allele appears to be associated with higher plasma cholesterol and is also associated with an increased risk of AD. The role of plasma apo E concentration as a risk factor in these conditions is unclear investigated and is the focus of this project. A prerequisite to the study of apo E as a risk factor is an understanding of the factors controlling apo E concentration in health. The first working hypothesis of this project is that apo E plasma concentration is determined by an interaction of environmental (e.g. obesity, diet) and genetic factors (in particular apo E genotype). The second working hypothesis is that apo E concentration together with apo E genotype serves as a risk marker for AD and CAD. Thus, the project will determine the factors affecting interindividual variation in apo E plasma concentration, in particular the role of apo E genetic polymorphism and to establish apo E genotype related reference ranges for plasma apo E concentration in healthy subjects. The distribution of apo E genotype / apo E plasma concentration across different European populations will be investigated. The role of apo E plasma c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SMART LEG [STEP 2] OPEN SEA TESTING' in the context of a Fourth Framework call.

assistant: **Objectives**

Smart-Leg is float over method for deck installation and deck removal by using conventional cargo barge and specific equipment instead of heavy derrick barge. Thus the Smart-Leg Method should lead to drastic reduction in deck installation costs and should contribute to safer offshore operations for staff and equipment.The Smart-Leg Concept has been validated with a 1/40 physical scale model within the THERMIE project OG./287/94 (Step. 1). In the continuity of the Step 1, the aim of the proposed project is to demonstrate the technical and economical advantages of the Smart-Leg Method through the installation of a 4500 ton 6 legs deck at Ekpe Field.The shockless floatover occured on June, 3rd 1997. It has been a highly successful operation.Smart-Leg STEP 2 Open Sea Testing is the second step of the SMART-LEG Project which first phase has been achieved by December 1995.1) INNOVATIVE TECHNOLOGYThe Smart-Leg concept involves new technology for existing applications and new applications. New technologyThe Smart-Leg Method is shockless: deck installation in open sea is performed while the impact of shocks caused by waves are eliminated by the method itself. Moreover, the Jacking Method is passive by using energy of waves to lift deck.Applications:The Smart-Leg method extends the limit for deck installation: heavier weight, shallower waterdepth, more severe environmental conditions. Moreover, the Smart-Leg Method will contribute to a substantial reduction for offshore oil and gas exploitation costs: by cutting down the installation costs and by saving time in production start-up.2) THE CONEXT IN WHICH THE TECHNOLOGY IS OPERATINGThis new technology will operate in the offshore platforms installation market. Potential users are the oil and gas Companies-operating offshore. The co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Contentious Politics in an Age of Austerity: A comparative study of anti-austerity protests in Spain and Ireland' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The proposed two year mobility involves undertaking research and training in the Department of Sociology at the National University of Ireland, Maynooth (NUIM), from the fellow’s current location at the University of Aberdeen, Scotland. Under the mentorship of Professor Seán Ó Riain, an expert in global political economy, the social aspects of the current financial crisis, and global ethnography, she will undertake a comparative study on anti-austerity mobilizations in Ireland and Spain to explain their widely divergent trajectories, thereby contributing important empirical knowledge while advancing major theoretical issues in contemporary research on contentious politics. The study will draw on the fellow’s expertise in European social movements to develop ongoing theoretical work on processes of transnational diffusion, movement latency, collective identity formation and use of ICTs in explaining the emergence and dynamics of social movement mobilization.The host department provides expertise in Irish politics, history, and comparative political research. The Department of Sociology at NUIM is Ireland’s leading centre for the study of social movements. The applicant will benefit from training and skills development in the areas of cross-national comparative methodology, and social movement practitioner focused pedagogy, both specializations of the host department.Public outreach activities include a series of public engagements with policy makers, civil society groups, students and the general public in the area of European contentious politics; a project website; and media engagement. The project will further the applicant’s career by enabling her to consolidate her leadership in the area of European social movements, and acquire methodological training, mentoring an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fluid Flows and Irregular Transport' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Several important partial differential equations (PDEs) arising in the mathematical description of physical phenomena exhibit transport features: physical quantities are advected by velocity fields that drive the dynamics of the system. This is the case for instance for the Euler equation of fluid dynamics, for conservation laws, and for kinetic equations.An ubiquitous feature of these phenomena is their intrinsic lack of regularity. From the mathematical point of view this stems from the nonlinearity and/or nonlocality of the PDEs. Moreover, the lack of regularity also encodes actual properties of the underlying physical systems: conservation laws develop shocks (discontinuities that propagate in time), solutions to the Euler equation exhibit rough and ""disordered"" behaviors. This irregularity is the major difficulty in the mathematical analysis of such problems, since it prevents the use of many standard methods, foremost the classical (and powerful) theory of characteristics.For these reasons, the study in a non smooth setting of transport and continuity equations, and of flows of ordinary differential equations, is a fundamental tool to approach challenging important questions concerning these PDEs.This project aims at establishing:(1) deep insight into the structure of solutions of nonlinear PDEs, in particular the Euler equation and multidimensional systems of conservation laws,(2) rigorous bounds for mixing phenomena in fluid flows, phenomena for which giving a precise mathematical formulation is extremely challenging.The unifying factor of this proposal is that the analysis will rely on major advances in the theory of flows of ordinary differential equations in a non smooth setting, thus providing a robust formulation via characteristics for the PDEs under con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'KRAB/KAP1-mediated gene regulation in mammalian physiology and human diseases' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This project aims at exploring the roles or KRAB/KAP1-mediated gene regulation in mammalian physiology and the possible impact of its dysfunctions on human health. The proper control of gene expression is paramount to all biological events, and is orchestrated through a sophisticated balance of activating and repressing influences. The mouse and human genomes contain around four hundred genes encoding KRAB-containing zinc finger proteins (KRAB-ZFPs), a family of tetrapod-restricted sequence-specific DNA-binding transcriptional repressors. Even though these KRAB-ZFPs represent the single largest group of transcriptional regulators encoded by higher vertebrates, their functions remain largely unknown. Nevertheless, it has been established that they share an essential cofactor, the histone methyltransferase- and histone deacetylase-recruiting KAP1, and act by triggering the formation of heterochromatin. KAP1 is ubiquitous, and KRAB-ZFPs are present in most if not all cells, albeit along distinctly cell type-, stage- and state-specific patterns, suggesting that KRAB/KAP1 gene regulation influences a very large number of physiological events. A few years ago, we launched a program aimed at addressing this hypothesis through a combination of genetic, functional and molecular studies focused on two paradigmatic organs, the lympho-hematopoietic system and the liver. Our preliminary results confirm that KRAB/KAP1-mediated transcriptional control is a master regulator of mammalian homeostasis. Accordingly, we now propose to dissect the regulatory networks orchestrated by KAP1 and KRAB-ZFPs in these two systems, to identify their gene targets and the mechanisms of their control, and to probe their possible implication in human pathologies targeting these organs.