RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Bugs4Urate - Precision Nutrition Strategies for Investigating Probiotic, Diet, Glycan, and Microbiome Factors in Hyperuricemia and Gout Prevention'.

assistant: **Concept**

Gout is a prevalent lifestyle related NCD on the rise in Europe causing low quality of life, yet with inefficient means for treatment. An effective approach to manage hyperuricemia, the precursor to gout, would significantly enhance health outcomes and have a profound impact.Using a novel probiotic food-ingredient with urate-lowering properties we target the gut microbiome to eradicate urate in a precision nutrition framework where contextualizing factors of the habitual diet, host gut microbiome, and host genetics is used to establish a responder / non-responder instrument. We will employ a diverse array of methods, encompassing machine learning applied to existing clinical and omics observational data, ex-vivo dietary fiber and probiotic refinement, and two human intervention studies. In healthy adults (n = 8) we will conduct a mode-of-action study utilizing a crossover design including small intestine biopsy sampling to assess local activity. In hyperuricemic participants (n = 99) we will conduct a three-armed, placebo-controlled proof-of-concept study to access the efficacy of probiotic treatment (with and without fibre), combined with a responder / non-responder instrument.  Using comprehensive longitudinal analyses in metabolomics, microbiome, transcriptomics, and glycomics, we aim to uncover the molecular dynamics between dietary patterns, established bacterial enzymatic processes, urate breakdown, and the resultant shifts in inflammation within the gut and throughout the circulatory system. By innovating the glycomics technology to accommodate alternative bio-specimens, we hope to enable straightforward home sampling and initiate early diagnostic procedures for broad population oversight. Through the application of multi-omics, we aim to develop an effective res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Chiral Plasmons in Protein-Nanoparticle Hybrid Materials for Application as Biosensors' in the context of a Horizon 2020 call.

assistant: **Objectives**

The real challenge in the field of nanomaterials is to fabricate hybrid systems that can function as smart materials in a wide variety of applications. Hybrid systems possessing protein templates can be potential candidates in this direction due to the wide variety of applications possible in biological systems. The project outlined below aims at the synthesis of novel hybrid conjugates based on protein templates and gold/silver nanoparticles (NPs)/nanorods (NRs) as plasmonic materials to generate chiral plasmons. Different proteins will be utilized for the fabrication of two different chiral templates: (i) helical one dimensional aggregates and (ii) chiral crystals. The plasmonic metal NPs/NRs can be introduced on these templates utilizing electrostatic and covalent interactions resulting in chiral plasmons. The mechanism of chirality transfer from the template to NPs/NRs can be studied by the detailed crystallographic investigations of the template, nanoparticle and their heterojunctions. The extent of chirality transfer would depend largely on the nature of the template and hence the project aims at fabricating hybrid systems wherein the transfer of chirality from the template to the plasmonic material is efficient. The hybrid systems can be used for enhancing the spectroscopic signals of molecules in Surface Enhanced Raman Scattering (SERS). Our ultimate goal is to utilize the hybrid chiral systems as biosensors (i) for the detection of assembly and disassembly of proteins as well as (ii) for understanding crystallographic changes in medication. The importance of the first part is emphasized by the fact that the assembly of proteins is the cause for various neurodegenerative diseases and its disassembly can be an effective mode of therapy. On the other hand, the ins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Non-equilibrium features of small systems within critical liquids.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

NEQLIQ aims to contribute to the European Research Area (ERA) by developing new fundamental knowledge about the features of small systems. Particularly, NEQLIQ will focus on the dynamics and energetics of small systems within critical baths. Critical interactions have been proposed to play a key role in the performance of living systems, and they have great perspectives to be applied to artificial devices. NEQLIQ is based in: i) micelle-solvent mixtures to enhance the intrinsic critical features of a binary-fluid, ii) a combination of microrheology and dynamic light scattering for determining the impact of confinement or inclusion of tracers in the viscoelastic features of the fluid, and iii) the study of the statistics of the energy transfer by non-equilibrium thermodynamic protocols. The objectives of NEQLIQ have a direct impact on some of the ‘Societal Challenges’ listed in H2020 i.e. ‘Secure, Clean and Efficient Energy’ and ‘Climate Action, Environment, Resource Efficiency, and Raw Materials’. NEQLIQ will merge the expertise of the host group in surfactants, micelles, and microfluidics, together with the background of the applicant using optical micromanipulation technique to unravel the fundamental features of the energetics of small systems, to reach the scientific objectives and technological challenges, to reach the desired deliverables and milestones. An ambitious training program including several new scientific and soft skills to be transferred to the applicant is also envisaged. Moreover, the applicant will transfer his knowledge to the host group and will be the link between them to forge future collaborations. Altogether, NEQLIQ will give the candidate a challenge to gain new expertise in different areas of research and new soft skills and leadership capac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advancing Smart Optical Imaging and Sensing for Health' under Horizon 2020.

assistant: **Concept**

The ageing population and related increase in chronic diseases put considerable pressure on both the healthcare system and the society, resulting in an unsustainable rise of healthcare costs. As a result there is an urgent need to improve efficiency of care and reduce hospitalisation time in order to control cost and increase quality of life. Addressing this need, medical applications need to become less invasive and improve disease detection, diagnosis and treatment using advanced imaging and sensing techniques. ASTONISH will deliver breakthrough imaging and sensing technologies for monitoring, diagnosis and treatment applications by developing smart optical imaging technology that extends the use of minimally invasive diagnosis and treatment and allows for unobtrusive health monitoring. The project will integrate miniaturized optical components, data processing units and SW applications into smart imaging systems that are less obtrusive, cheaper, more reliable and easier to use than state of the art systems. This results into 6 demonstrators by which the technologies will be validated and which allow for pre-clinical testing in the scope of the project.The overall concept within ASTONISH builds on the development and application of common imaging/sensing technologies. Smart algorithms, multimodal fusion techniques and biomedical signal processing will process the acquired data and advanced user interfaces will simplify the complex clinical tasks. These technology components will be integrated to build application specific solutions for physiological signs monitoring, tumour detection, minimally invasive surgery, brain function monitoring and rehabilitation. The ASTONISH partners cover the full value chain, from semiconductor manufacturing to clinical centres testing t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Organ on Chip in Development' (ORCHID).

assistant: **Concept**

Organ-on-chip technology will revolutionize the healthcare domain by offering new and ground breaking solutions to different industries and especially for regenerative medicine and medication.ORgan-on-Chip In Development (ORCHID) will create a roadmap for organ-on-chip technology and the framework to build a network of relevant stakeholders. ORCHID will achieve this through 5 objectives: (i) evaluation of the technology (state of the art and unmet needs), (ii) identification of ethical issues, establishing standards and identifying measures for regulatory implementation, (iii) analysis of economic and societal impact, training and education, (iv) developing a roadmap which will guide the required R&D efforts and (v) raising awareness and building the ecosystem for organ-on-chip technology through a digital reference platform .ORCHID will have a broad impact: it will facilitate  drug development,  contribute significantly to reducing animal experiments and help in developing personalized medicine. ORCHID will achieve these goals by providing a framework to the main stakeholders, bringing together key players and raising awareness on organ-on-chip technology throughout Europe. The digital platform will gather all information on existing and new initiatives in the field. In this way ORCHID as a whole will secure and reinforce Europe’s leadership on organ-on-chip.The consortium is composed of the main contributors to the field who are all very experienced and who will strongly collaborate with each other. Leiden University Medical Centrum (LUMC) will lead the consortium, the Institute for human Organ and Disease model (hDMT) will focus on the strategy and the roadmap, Fraunhofer IGB on impact assessment, CEA Leti on eco-system development and the digital platform, IMEC on t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Unraveling the origin of the Initial Mass Function'.

assistant: **Innovation**

Despite the tremendous progress achieved over the past decade, the study of stellar formation is far from complete. We have not yet measured the minimum mass for star formation, nor the shape of the IMF down to the least massive free-floating planets, or know how universal this shape is. Although clusters are the building blocks of galaxies, little is known about their early dynamical evolution and dispersal into the field. The main culprit for this state of affairs is the high level of contamination and incompleteness in the sub-stellar regime, even for the best photometric and astrometric surveys.COSMIC-DANCE aims at overcoming these drawbacks and revealing the shape of the IMF with a precision and completeness surpassing current and foreseeable surveys of the next 15 years. We will: 1) Measure: using a groundbreaking, proven and so far unique method I designed, we will measure proper motions with an accuracy comparable to Gaia but 5 magnitudes deeper, reaching the planetary mass domain, and, critically, piercing through the dust obscured young clusters inaccessible to Gaia’s optical sensors.2) Discover: feeding these proper motions and the multi-wavelength photometry to innovative hyper-dimensional data mining techniques, we will securely identify cluster members within the millions of sources of the COSMIC-DANCE database, complemented by Gaia at the bright end, to obtain the final census over the entire mass spectrum for 20 young nearby clusters, the end of a 60-year quest.3) Understand: by providing conclusive empirical constraints over a broad parameter space unaccessible to current state-of-the-art surveys on the much debated respective contributions of evolutionary effects (dynamics, feedback and competitive accretion) and initial conditions (core properties) to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Actions for Excellence in Smart Cyber-Physical Systems applications through exploitation of Big Data in the context of Production Control and Logistics' (EXCELL) targeting Horizon 2020.

assistant: **Abstract**

EXCELL foresees the collaboration of academics from 4 EU countries (HU, DE, UK, BE) in the multidisciplinary topic of Big Data Applications for Cyber-Physical Systems in Production and Logistics Networks. The main scientific and innovation focus of EXCELL was devised both from world-wide tendencies and local requirements (expressed by the regional S3), departing from the present competences of the cooperating partners (SZTAKI, Fraunhofer-FIT, Aston, and KU Leuven).Main project actions focus on:• Knowledge acceleration through transnational secondments and training sessions in 8 selected Priority Research Fields (PRFs) and 6 Complementary Skills, • Supporting exploitation of research results and user-driven innovation,• Augmenting scientific impact actions through key publications and active participation in the scientific discourse,• Dissemination and sustainable innovation.The 8 PRFs are: 1.Cyber-Physical Systems and Human System Interaction (responsible Fraunhofer), 2.Business-based Internet of Things and Services (resp. Fraunhofer), 3.Next-generation Authentication and Authorization Solutions (resp. KU Leuven), 4.Enhanced Context-aware Services (resp. KU Leuven), 5.Cognitive modelling and social networking approaches (resp. ASTON), 6.Data mining (resp. ASTON), 7.Data interoperability (resp. SZTAKI), 8.Tracking and tracing (resp. SZTAKI).The Complementary Skills include: Technology transfer and results deployment to industry, Emotional intelligence, Motivating others, Personal impact, Stress management for managers, and Hands-on experience by using and contributing to software tools. EXCELL activities are aligned towards 4 major types of impact: 1. Scientific impact, 2. Industry-driven innovation and technology transfer, 3. Sustainability and exploitation, 4. General
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Homeoproteins as novel therapies for neurodegenerative diseases' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

With the ageing of the population, neurodegenerative diseases will be a huge societal, health and economic problem. There are no effective solutions that can stop the progression of these devastating diseases. At BrainEver we are developing a groundbreaking platform to treat neurodegenerative diseases based on a family of transcription factors called Homeoproteins (HPs). Homeoproteins are endogenous proteins expressed in diverse neuronal types, where they regulate age-dependent mechanisms related to neurodegeneration. When homeoproteins are injected into the central nervous system of animals with disease, neuronal survival and function is restored, halting degeneration. This suggests a huge potential as therapies for neurodegenerative diseases. In this project, we aim to develop and clinically validate a revolutionary therapy using the homeoprotein Engrailed-1, to treat patients with Amyotrophic Lateral Sclerosis (ALS)  and Parkinson’s Disease (PD).


**Keywords:** Amyotrophic Lateral Sclerosis,Parkinson’s,homeodomain proteins,epigenetics,motor neuron disease,gene therapy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Intelligent surveillance and management functions for airfield applications based on low cost magnetic field detectors' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The objective of this project is to determine whether recent advances in magnetic sensors could provide a better means of surface movement surveillance at airports. Therefore the physical principles are used as a starting point to provide the best magneto resistant material for this task. This will be integrated into an advanced sensor head that provides the analogue signal to be interpreted by the digital processing unit. The combination of these two parts will form the innovative detector, providing reliable information at low cost.Particular attention will be paid to usability and accessibility of the detection technology and related services. System tests will be performed in a realistic application environment thus enabling real-life-feedback and validation as well as immediate optimisation inputs. The respective test infrastructure will be a medium-sized Greek airport and a large-sized German airport featuring conditions representative for most European airports. This overall approach shall help to pull the technology development with applications and services.The complete development of the system will be prepared by a solid elaboration of the relevant user requirements on a technical, an economic and legal level. For the evaluation, ISMAEL performs a comprehensive assessment of the new system under the aspects of technical performance and impacts on other systems. It evaluates the socio-economic aspects of the system to give first indications on the impacts of the proposed technical solution and thus enabled or improved applications on potential users as well as on society.The process of exploitation will deliver the basis for improvements of the detector systems and their further development towards marketable products. Thus a strategy will be established towar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'EU ERA Chair in Digital Cultural Heritage: Mnemosyne' (MNEMOSYNE) under Horizon 2020.

assistant: **Objectives**

Cultural Heritage is a strategic resource for Europe with high cultural, social, environmental and economic value. The era of Digital Cultural Heritage (DCH) is now well underway and the European research resource for DCH  has grown significantly in recent years. But the visible contribution of the Widening countries to this effort remains relatively weak. The Digital Heritage Research Laboratory (DHRLab) at Cyprus University of Technology (CUT) has been an exception in this respect, becoming a beacon in the Eastern Mediterranean and for Europe in general, in particular through its leadership of key initiatives in DCH research training and in policy co-ordination and support. While the Cypriot economy gradually recovers, in order to maintain and expand its leading role in DCH research, DHRLab needs further investment. The call for ERA Chairs is an ideal opportunity to ensure this by means of a well-designed and iterative process of strengthening its research capacity and restructuring of its role. Mnemosyne will proceed from the appointment of an outstanding researcher and research manager as ERA Chair holder in 2018 who will attract, direct and maintain high quality human resources and negotiate and implement the necessary structural changes to achieve excellence on a sustainable basis. The project will be carried out over a period of 5 years. Following recruitment of the ERA Chair Research Team, a three-phase research programme centred on holistic documentation of the DCH life cycle in support of existing and potential user needs will be carried out and extensively evaluated, with strong attention paid to exploitation. Communication activities, will be strategically planned and refined from the outset of the work and will last throughout the project duration.


**Keyw