RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Innovation Relay Centre for Lombardy region'.

assistant: **Objectives**

The main objective of this project is to set up an IRC, to promote TTT together with stimulating the capacity of enterprise to adopt new technologies, according to needs expressed by local clients and the IRC network. The IRC aims at playing a key role in the Lombardy Region as a point of reference for SMEs in TTT matters: in a context of SMEs with a high attitude towards internationalisation but intrinsic difficulties in dealing with innovation matters, IRC services can effectively support regional policie s to improve competitiveness. The proposing Consortium is formed by Cestec, Lombardy Region Agency for Innovation for SME's, Chamber of Commerce of Milan, Politecnico Innovazione and Fast, that will share and combine their experience so as to promote syne rgies among them. Cestec, through its important experience in dealing with SMEs, will co-ordinate the IRC. Lombardy Region, the Regional Authority, strongly supports IRC initiative and will participate to IRC Steering Committee in order to give strategic advise to the IRC Partners. It will also contribute financially to 50% of the costs incurred.The Chamber of Commerce will provide a privileged access to local industrial domain, while CPI,the technology transfer Agency of Politecnico di Milano and Fast, the major Italian technical Association, will also provide the Consortium with their long experience matured as partner of the network since its very beginning.The work-plan has been designed with the aim of identifying and analysing technology needs, dr awing technology profiles, developing transnational links in the framework of a co-operation with the other nodes of the IRC network, in order to achieve 40 successful TT Agreements. The activities to be carried out in terms of: 1)provision of awareness an d informat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Developing CRISPR activation/CRISPR interference toolset for fine-tuning production of metabolites in plants' in the context of a Horizon Europe call.

assistant: **Objectives**

Plants produce a great variety of specialised metabolites. In plants they are often involved in interactions with their environment, but many of them have applications in pharmaceutical, cosmetic, and food industries, making them targets for metabolic engineering efforts aiming to increase their production. Plant metabolic engineering is usually based on metabolic pathway reconstitution in microbes, but recently direct activation of biosynthetic genes has been done in plants using CRISPR tools. METABOTUNE aims to develop a CRISPR toolset for simultaneous activation and inactivation of metabolic genes to fine-tune biosynthesis and maximise yields of specialised metabolites. First, I will develop a CRISPR interference (CRISPRi) tool for inactivating genes that channel metabolites into undesired metabolic pathways. Second, I will identify genes involved in the biosynthesis of a coumarin metabolite with medicinal properties, esculetin. Finally, CRISPRi will be applied together with the already available CRISPR activation (CRISPRa) tool in development of plant cell cultures specifically producing esculetin and the minimal amount of other coumarins. To achieve these objectives, I will combine my expertise in molecular biology, genetics, specialised metabolites, and biochemistry with the expertise in metabolic engineering and coumarins available at the host institute. Allowing precise channelling of metabolites into pathways of interest, as proposed here, will open new venues for highly specific plant metabolic engineering efforts and allow a shift from production in microbes to increasing production in plant species that already have genes required for biosynthesis of high-value specialised metabolites.


**Keywords:** Specialised metabolites, CRISPR, coumarins, metabolic eng
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Air Launch space Transportation using an Automated aircraft and an Innovative Rocket' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

ALTAIR’s strategic objective is to demonstrate the feasibility of a new cost effective and reliable space launch system for the access to Low-Earth Orbit (400-1000 km) of small satellites ranging from 50 to 150 kg. The ALTAIR launch system aims to be the expected answer to the needs of small satellites users, providing an affordable and adapted access to space service, without the constraints of current rideshare launch options. ALTAIR will boost space applications to the benefit of an increased spectrum of users, from classic satellite operators to academics and research centres.To support this ambitious goal, the ALTAIR system combines an innovative semi-reusable concept and the integration of relevant technologies in all parts of the system. ALTAIR is an innovative air-launch system using a reusable unmanned aircraft carrier optimised specifically for this mission. The expendable rocket launch vehicle, which is released at high altitude, associates green propellant hybrid propulsion, lightweight composite structure, innovative avionics and a versatile upper-stage, providing mission flexibility. Cost-effective ground operations are obtained through innovative ground systems architecture.ALTAIR will pave the way for a feasible system ready to address the market’s need through an original approach associating a cost-oriented preliminary design of the whole system (carrier vehicle, launch vehicle and ground segment) using advanced Multidisciplinary Design Optimisation techniques, and the definition of a credible development roadmap and business model, supported by market analyses. The design will be supported by flight experimentations for key technologies using the existing small scale demonstrator EOLE.The 36-month ALTAIR project benefits from a solid and proven herita
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sustainable industrial development: capacity strengthening of the institute of environmental engineering' under Fifth Framework.

assistant: **Concept**

The project will support development of theoretical and applied research capacity of APINI in sustainable industrial development with the ultimate goal of improving environmental, economic and social conditions in Lithuania and facilitating the process of the country's integration to the EU through increased networking and cooperation with advanced European centres; increased networking with and scientific support for different stakeholders in implementing Water Policy Framework Directive, Integrated Pollution Prevention and Control Directive, Eco-Management and Audit Scheme, Integrated Product Policy; increased scope and quality of research, particularly application of modern systems theory to sustainable industrial development problems; increased regional coverage of the research activities in the Baltic Region.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Ultra-Low Frequency Universe' (ULU).

assistant: **Innovation**

The ULU project will explore the largest scales of our Universe mapping one of the last uncharted observational windows of the cosmic electromagnetic spectrum: the ultra-low radio frequencies (10-100 MHz). Although these frequencies are crucial to unveil the nature and evolution of galaxy clusters, the complexity of such observations prevented their exploitation until now. Techniques I developed to analyse Low Frequency Array (LOFAR) data were able to overcome this limitation. With ULU we will survey the northern sky producing ultra-low frequency images that are 100 times more sensitive than the state-of-the-art. The legacy of ULU will be long lasting with a far reaching scientific outcome: from galaxy evolution to ionospheric science, from exoplanet habitability to the detection of the first galaxies at cosmic dawn.Within the ULU project, I will combine the survey with my expertise on the study of galaxy clusters. My group will adopt an innovative approach based on unveiling the full picture of the cosmic ray (CR) life-cycle in the intracluster medium, effectively combining diverse topics historically studied independently, such as the growth of structures, AGN activity, and galaxy evolution. While conventional radio frequencies are sensitive to emission generated by highly energetic CRs, with ULU we will explore the far larger domain of low-energy CRs that can be accelerated by still unexplored microphysical mechanisms. Furthermore, their emission can be observed over Gyr time scales, revealing the long-term actions and interactions of radio sources in cluster environments. With a full picture of the CR life-cycle we will 1. unveil how cluster merger energy is deposited in the intracluster medium through shocks, turbulence and other mechanisms, 2. measure the long-ter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced imaging techniques for assessing the potential of a cell therapy to improve the health of ex vivo perfused marginal kidneys' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Kidney transplantation is the gold-standard for end-stage kidney disease (ESKD) but there is a shortage of organs. To increase organ numbers, kidneys from deceased donors aged over 60 are now often used. These so-called “marginal” kidneys are susceptible to the ischemic tissue damage that occurs during transplantation, and tend not to function as well, nor last as long, as kidneys from younger donors. Cell therapies administered into the renal artery prior to transplantation have potential to repair marginal kidneys. Adipose derived regenerative cells (ADRCs) are an attractive cell therapy because they can be isolated from the perinephric fat surrounding the donor kidneys, and can improve kidney health in rodent models. However, difficulties in evaluating ADRCs in human donor kidneys is a barrier to clinical translation. We need to monitor the biodistribution of the cells within the kidneys to ensure they do not form emboli, as well as measure the therapeutic effects of the cells on kidney function and tissue health. Recent technological advances in machine perfusion and imaging makes it possible to overcome these barriers. With machine perfusion, kidneys can be perfused outside the body (ex vivo) prior to transplantation, allowing their function to be assessed. Furthermore, a highly sensitive novel imaging technique called “magnetic particle imaging” (MPI), will enable the biodistribution of labelled cells to be determined with great accuracy. In this project, I aim to address these questions using marginal human kidneys that are not deemed suitable for transplantation. The University of Liverpool is uniquely positioned to host my project, being the only centre in Europe with expertise in both ex vivo perfusion as well as having an MPI scanner. If successful, my projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Illuminating human Fe-S cluster biology'.

assistant: **Concept**

Iron-sulfur (Fe-S) clusters were ancient partners in the origin of life- spontaneously formed in the anaerobic primordial oceans, they likely helped catalyze carbon fixation and rudimentary metabolism. Highly versatile, Fe-S clusters unlock previously inaccessible abilities for their binding proteins, aiding in electron relay, catalysis, regulation, and structural stability. Over the past 20 years, it has become clear that Fe-S clusters must be formed de-novo within the cell by essential proteinaceous machineries and relayed directly to their binding proteins. During this time, huge strides have been made to delineate the components and molecular mechanisms of this pathway. However, our grasp of the regulation, client range and dynamics of Fe-S cluster biosynthesis in the human cell remains fragmented. These critical gaps of knowledge hinder our understanding of how Fe-S cluster biosynthesis supports healthy human cells and how its breakdown can lead to multiple diseases.We aim to break through to a new level understanding of human Fe-S cluster biosynthesis– catapulting our knowledge forward to encompass its holistic cellular state. In FeSurveil, we will broadly and unbiasedly identify the human Fe-S cluster proteome (Aim 1), uncover regulators of Fe-S cluster biosynthesis (Aim 2), and dissect client priorities for the relay proteins (Aim 3). FeSurveil will leverage our expertise in Fe-S cluster biology and capitalize on our unique interdisciplinary skills, spanning tool creation, state-of-the-art genetic profiling, proteomic analysis, cell biology and biochemical approaches. Together, these independent but synergistic lines of research will illuminate the complex reciprocal relationship between Fe-S cluster biosynthesis and the dynamic cellular environment. This compre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Physical principles of recognition in the immune system.'.

assistant: **Objectives**

Receptor proteins on the surfaces of B- and T-cells interact with pathogens, recognize them and initiate an immune response. The diversity and complexity of immune receptors poses a challenge to nonequilibrium many-body physics and our understanding of the physical principles that control the emergent functional properties of biological systems, such as recognition. The diversity of the composition of the immune repertoire emerges as a self-organized process, stimulated by interactions with the environment. The goal of the proposed research is to study the self-organization of the immune repertoire in the face of its pathogenic environment at the molecular and evolutionary level, by using a combination of data analysis and statistical mechanics modeling.Recent experiments have determined the set of B-cell receptors found in a zebrafish and T-cells in humans – data that allows for theoretical analysis and hypotheses rejection that were never possible before. I will theoretically study the problem of recognition from four unique and complementary directions:- guided by statistical signatures in the data I will propose evolutionary models of how selection and mutation in the sequences lead from the genomic precursors to a functional repertoire of receptors,- I will quantify, under simplifying assumptions, the question of the optimal repertoire for recognition in a varying but partially predictable pathogenic environment using maximum likelihood,- analyzing sequence data I will build probabilistic models to characterize the molecular scenarios that generate the repertoire,- I will use information theory and statistical methods to build data-driven models of the molecular nature of recognition based on yeast display experiments.Describing interactions between elements of rec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Industrial scale PET chemical recycling plant based on innovative glycolysis process'.

assistant: **Objectives**

Polyethylene terephthalate (PET) is a Thermoplastic Polymer increasingly used in several applications due to its excellent physical and chemical properties.With the increase in the amount of PET wastes, its disposal began to pose serious economic and environmental problems; current PET waste disposal options include incineration, landfilling and recycling. Landfilling and incineration are outdated processes, their environmental impact is high and the dependency from crude oil is critical. Recycling is the preferred option for the treatment of waste PET: plastics must be a resource and their recycling is the only way to make sustainable the plastic production chain in Europe without loss of material.The recycling of PET does not only serve as a partial solution to the solid waste problem but also contributes to the conservation of raw petrochemical products and energy.The proposed project aims at implementing an industrial plant to produce high quality PET through the chemical recycling of PET wastes (icluding opaque & multi-layer) and promotes true sustainable development of PET production enabling virtually endless PET re-use.Garbo’s chemical recycling technology represents a novel and industrial applicable technology for the transformation of PET based wastes in monomer (BHET) that can be purified and re-used in the production of PET as raw material instead of terephthalic acid (TPA) and ethylene glycol (EG), with enormous advantage for the polyester value chain in terms of competitiveness and jobs creation.The Garbo's technology serves 3 purposes:helping Europe to obtain “Zero Plastics to landfill by 2025” recommended by the most important associations in the plastic market promoting the Circular Economy Package as required by the European Plastics value chain and re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Innovative cancer therapy through Myc inhibition: taking OMO-103 to market'.

assistant: **Innovation**

Cancer is a global challenge with 9 millions (M) deaths annually and new cases projected to rise by 70% in the 20 years, and there is a clear and pressing need for more effective therapies. In the EU, lung cancer is the most common cancer in men and the third most common in women, with 2 M new cases in 2018 accounting for ~20% of all cancer deaths. Despite considerable recent advances in lung cancer treatment, current treatments are still too often ineffective or highly toxic. Peptomyc is a unique biotech SME that is revolutionizing cancer treatment with its ground-breaking innovative cancer therapies inhibiting Myc. Our patented product OMO-103 is able to penetrate the nuclei, attack Myc and kill cancer cells. In contrast, most current therapies attack redundant cell surface receptors or proteins that can be compensated by tumours, which then evolve resistance. Our company combines scientific excellence with sound business acumen: our scientific leadership in Myc inhibition builds on 20 years of world-class scientific record, and in just 3 years after the foundation, we closed 2 rounds of equity investments with Venture Capitals. Peptomyc aims at licensing its technology to pharmaceutical companies. Financing through this SME Instrument project will enable us to take to the market our first product, OMO-103 by completing clinical trials and reach a licensing agreement with a pharmaceutical company for full scale production and commercialization. Our results so far show that OMO-103 is: Safer (no toxicity), More efficient (no resistance observed), and More effective (increased survival in lung cancer models). With MYCure, we will take to market our first-in-class Myc inhibitor OMO-103 to treat non-small cell lung cancer, for which the global market is expected to reach