RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The electrosolvation force: a new physical paradigm in chemistry and biology' (ELECTROSOL) targeting Horizon Europe.

assistant: **Abstract**

Over the last several decades, dating back to the work of Langmuir, and Rosalind Franklin, the literature has consistently reported on a long-ranged attraction between particles in solution carrying electrical charge of the same sign. This attraction is not explained by standing theories and has remained an open conundrum. My laboratory has recently made important progress in elucidating the underpinnings of this phenomenon, introducing an “electrosolvation” force that drives spontaneous attraction and cluster formation in like-charged particles in solution. The force is long-ranged and is governed by the orientation of solvent molecules at the particle-electrolyte interface. The sign of the force exhibits an asymmetric response to the sign of charge of the particle: e.g., in water, negatively charged particles counterintuitively attract, whilst positives repel as expected, and vice versa in other solvents. This fundamental and unexpected mechanistic insight now opens for the first time the possibility to systematically investigate the origins of a host of poorly understood natural processes that are likely governed by this interaction, touching virtually all areas of the life sciences and beyond. Noteworthy examples include interactions driving biomolecular condensation, pathological protein aggregation, crystallization, gelation and DNA packing.  We will carry out an in-depth experimental exploration of the interaction across length scales - from molecules to microspheres and macroscopic surfaces - using cutting edge experimental methods pioneered in my laboratory. We will further advance a fundamental understanding of the interaction through theoretical modelling and simulation. This comprehensive investigation will likely lead to the establishment of a broad and gen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Contested urban territories: Ethnographic concept building for a more global urban theory' in the context of a Horizon 2020 call.

assistant: **Objectives**

Indigenous movements in Latin America exemplify alternatives ways of relating to urban nature. These different practices and ecological imaginaries at play in urban contexts could signal different routes for a more sustainable development. Yet, they remain under-investigated, this proposal argues, due to a lack of an adequate conceptual repertoire and methodological tools to analyse these practices. This is despite new starting points for a more global urban theory: while post- and decolonial scholars have argued to further diversify socio-spatial theory, scholars engaging with an ontological turn are rethinking dualisms separating nature and culture or urban and rural to open up new grounds to study urban political ecology.This project addresses this gap by building on Latin America-based scholarship to reframe these types of socio-environmental struggles as urban contestations, emphasising intersectional dimension of indigeneity, race and gender, to understand these multiply scaled processes. The main questions are: What practices do indigenous urban movements mobilize to defend their right to territory? How do the urban worlds enacted through these practices challenge and inform concepts and methods in urban studies more widely? Empirically, the research builds on a systematic comparative study of Mexico City (Mexico) and La Paz-El Alto (Bolivia) – cities marked with indigenous urban movements and rapid urbanization.This research will demonstrate novel strategies to compare different ecological and urban understandings. By advancing an interdisciplinary approach to analyse environmental conflicts in cities, the project will contribute to knowledge on urban development and provide a sound base to put forward suitable policy instruments to work towards sustainable citi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Industrial Production of Stable Fibroblast Growth Factors for Regenerative Medicine and Related Research Areas'.

assistant: **Concept**

The FGFSTAB project closes the gap between Enantis knowledge and expertise on protein engineering and the commercial applications of stable fibroblast growth factors (FGFs). FGFs are essential to the embryonic development, maintain tissue homeostasis, may slow down ageing of the organisms, and primarily promote angiogenesis and wound healing. FGFs see the greatest application in the care and treatment of chronic skin ulcers, but find use also in surgical and trauma wound healing. The global wound care market is rapidly growing due to the rising aging population and growing incidences of obesity and diabetes. Advanced wound dressings, such as those involving growth factors, play an important role in current regenerative medicine and companies around the world have started investing heavily in research and development of growth factor-based products. However, despite clinical value, applications of FGFs are limited by the fact that natural proteins have poor thermal stability and a short half-life in the circulation; they are often cleared from the body within hours, if not minutes, thus necessitating frequent administrations during the course of treatment, which goes hand in hand with a higher risk of adverse effects and lower cost-effectiveness of the protein therapy. The key objective of the FGFSTAB project is to use an innovative technological platform, based on the application of Enantis proprietary protein optimization concept FireProt, to increase FGF stability under various stress conditions. Additional challenges including high cost of production, current Good Manufacturing Practise, development of delivery systems for safe and effective wound healing, and pre-clinical testing to support future clinical trials and marketing authorization, will be targeted as well
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'INcreasing Safety in NPPs by Covering gaps in Environmental Fatigue Assessment'.

assistant: **Objectives**

INCEFA-PLUS delivers new experimental data and new guidelines for assessment of environmental fatigue damage to ensure safe operation of European nuclear power plants.Austenitic stainless steels will be tested for the effects of mean strain, hold time and material roughness on fatigue endurance. Testing will be in nuclear Light Water Reactor environments. The three experimental parameters were selected in the framework of an in-kind project during which the current state of the art for this technical area was developed. The data obtained will be collected and standardised in an online fatigue database with the objective of organising a CEN workshop on this aspect.The gaps in available fatigue data lead to uncertainty in current assessments. The gaps, will be targeted so that fatigue assessment procedures can address behaviour under conditions closer to normal plant operation than is currently possible. Increased safety can thus be assured.INCEFA-PLUS also develops and disseminates a modified procedure for estimating environmental fatigue degradation. This will take better account of the effects of mean strain, hold time and surface finish. This will enable better management of nuclear components, making possible the long term operation (LTO) of NPPs under safer conditions. INCEFA-PLUS is relevant to the NFRP1-2014 programme because:• Present guidance originates from NRC.  In Europe various national programmes aim to develop counter proposals allowing greater operational efficiency with at least comparable safety assurance.  INCEFA-PLUS brings these programmes together through which a strong EU response to the NRC methodology will be obtained with improved safety assurance through increased lifetime assessment reliability.• INCEFA-PLUS improves comparability of data from
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Automotive Intelligence for/at Connected Shared Mobility' (AI4CSM) targeting Horizon 2020.

assistant: **Abstract**

The European Green Deal defines 4 key elements for a sustainable mobility and automotive industry, namely: climate neutrality, zero pollution Europe, sustainable transport, and the transition to a circular economy. Digital technologies are a significant enabler for attaining the sustainability goals in mobility and transportation. The EC is taking initiatives to ensure that digital technologies such as AI, 5G, IoT and cloud/edge computing can accelerate the transition of the automotive industry  to electrical, autonomous, connected, and shared vehicles. The current COVID-19 situation accelerates this trend.The AI4CSM project will develop advanced electronic components and systems (ECS) and architectures for future mass-market ECAS vehicles. This fuels the digital transformation in the automotive sector to support the mobility trends and accelerate the transition towards a sustainable green and digital economy. Having assembled some of Europe’s best partners from industry, research and academia, AI4CSM will deliver key innovations in technical areas including: sensor fusion and perception platforms; efficient propulsion and energy modules; advanced connectivity for cooperative mobility applications; vehicle/edge/cloud computing integration concepts; new digital platforms for efficient and federated computing; and intelligent components based on trustworthy AI techniques and methods. ECAS vehicles enabled by embedded intelligence and functional integration for future mobility, becomes the pivotal factor for the automotive sector to address the Green Deal principles. AI4CSM consists of  8 collaborative R&D clusters, gathering 41 partners from 10 countries. AI4CSM will reinforce user acceptance and affordability by convenience and services for the major transition to a dive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications,antimicrobial drug resistance,and unresponsiveness to therapeutic HIV-1 vaccination' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The HIV/AIDS pandemic continues to be one of the major health challenges ever faced by mankind. Far from being resolved, HIV is soaring in Eastern Europe (60% increase in new infections and 27% increase in deaths since 2010) and other regions of the world despite increasing access to antiretroviral treatment. There is emerging evidence that the human microbiome impacts some of the most important clinical aspects of HIV-1 infection, including immune disorders, chronic inflammation and accelerated aging. Work in other viral diseases and cancer immunotherapy suggest a critical role of the human microbiome also in the outcome of immune therapeutic interventions in HIV-1 infection. The MISTRAL project brings together a team of world-class HIV and microbiome researchers and SMEs with ideal complementary knowledge and expertise. This team will work to discover and validate novel gut microbiome biomarkers to inform rationally-designed, mechanistically-driven interventions on the gut microbiome to mitigate HIV-1 acquisition, systemic inflammation, chronic clinical complications, antimicrobial drug resistance, and boost the efficacy of HIV cure immunotherapies. Integrated and curated large microbiome and host datasets generated during the execution of the project will be made public through a freely accessible, specifically-dedicated web-based repository. Biomarker discoveries will be incorporated into a cloud-based software tool that will automate microbiome analyses and interpretations, thus streamlining patient stratification for clinical and research purposes. If successful, MISTRAL will benefit millions of human beings living with, or at risk of acquiring HIV-1 infection, and will produce novel concepts and technical innovations applicable to other human diseases. By doing t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MULTI-MODAL INFORMATION AND TRAFFIC MANAGEMENT SYSTEMS ON TRANS-EUROPEAN-NETWORKS' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The dual purpose of INFOTEN is validation and demonstration of a multi-modal communication backbone for private and public traffic and transport information service in regions of the southern and eastern area of Europe and a public network of interoperable traffic information centres in the central and northern area of Europe to enhance the results of previous research. The communication backbone focuses on on-line telematics applications for intermodal transregional information for value added services on trans-European air, sea, rail and road networks in a public and private partnership. The public network between information centres will exchange relevant information between authorities so as to coordinate traffic management and to provide end-user information via collective dissemination media.In the context of the European Commissions' global concept for a common strategy for sustainable mobility it is the first objective of InfoTen to develop a multimodal communication network within and between regions of Austria, France, Germany, Italy and Switzerland as backbone for private and public traffic and transport information services and to interconnect Regional Traffic Information Centres operated by pubic authorities in the Central and Nothern Area of the EU to enhance existing interconnection prototypes which have been developed in the framework of DRIVE-I and the ATT-Programme, namely STRADA, EURO-TRIANGLE and INTERCHANGE, with respect to an overall interoperability (subproject Intermatrix). This backbone network is mainly used to demonstrate and validate in public and private partnership on-line telematics applications for intermodal transregional information for value added services on Trans-European (Air, Maritime, Rail and Road) Networks. In Intermatrix the ba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Variations In Motivation Across the Day - Understanding the How and Why of Daily Fluctuations' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Life on earth has evolved in synchrony with the day-night cycle. Most species, from single-cell plants to humans, have a circadian system that operates as a pacemaker, modulating a multitude of biological processes across the 24h period. Given the ubiquitous involvement of the circadian system in our physiology, it is not surprising that motivation and related neural systems such as dopamine also vary across the day, but with large variation between individuals. Time-of-day is increasingly being utilised to strengthen treatment effects and facilitate behavioural change. However, we still lack fundamental mechanistic knowledge for establishing more effective and widespread therapeutic applications in mental health care as well as in daily life. Hence, there is a need to more fully understand the circadian clock of motivation and drive. The objective is, first, to predict “when” (i.e., at which time of day) drive and motivation are heightened and blunted, and second, to scrutinise the underlying cognitive and neural mechanisms. Specifically, in phase 1, I plan to conduct a large-scale field study using a mobile application to quantify fluctuations in motivation to engage in daily-life behaviours and cognitive mechanisms including incentive motivation, reinforcement-learning, and cognitive flexibility. Then, in phase 2, I will use this knowledge to probe the role of dopamine in time-of-day effects of motivation by pharmacologically modulating dopamine at different times of day in a subset of the participants from phase 1. The combination of field research and basic experimental research will provide unique and clarifying knowledge of how and why motivation fluctuates both within and between individuals. Given the significant role of motivation in the healthy and sick brain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Challenging the hidden HIV: understanding the block on transcriptional reactivation to eradicate infection', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Highly active antiretroviral therapy (HAART) has profoundly decreased morbidity and mortality in human immunodeficiency virus type 1 (HIV-1)-infected individuals. Nonetheless, HIV-1 has not been eradicated by HAART. Factors affecting HIV-1 latency presen t formidable obstacles for therapeutic intervention and the need for novel therapeutic strategies specifically targeting HIV-1 latency has become evident. However, therapeutic targeting of HIV-1 latency requires an understanding of the basic mechanisms r egulating viral quiescence and activation. Exploring the scientific possibilities of new therapies targeting HIV-1 latency may hold new promise of eventual HIV-1 eradication. The proposal aims at identifying the key cellular and viral factors that control HIV latency and reactivation. Cellular factors that affect HIV-1 latency could be proteins controlling chromatin silencing and transcriptional reactivation through interaction with viral proteins, as well as small interfering RNAs produced naturally in t he infected cells that control silencing. Furthermore, we intend to explore the possibility that HIV-1 itself could modulate the cellular siRNA machinery to control its own expression. In order to approach these topics a wide array of techniques will be implemented. A Proteomic approach will be used to identify cellular factors involved in the control of viral latency and reactivation. The recruitment of these factors to the integrated viral promoter will be monitored by chromatin immunoprecipitation a nd by highly innovative fluorescent optical tools. Finally, the information gained from these basic studies will be exploited to design specific siRNA targeted to viral latency.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Exposure and risk assessment for fine and ultrafine particles in ambient air' (1994-1998).

assistant: **Concept**

Background: Several recent studies have shown that current levels of fine particles (often measured as PM10) in ambient air are associated with increased cardiovascular and respiratory morbidity and mortality. The main open question is, what are the characteristics of the airborne particles that are responsible for these health effects. Currently, the two leading theories are that they are either due to the very large number of ultrafine particles in urban air or that the chemical composition of particles, especially the transition metal content on the surface of the particles determines their health effects. However, there is very little data on levels and exposure to fine and ultrafine particles in Europe, on the elemental composition of particles, and on their health effects. Therefore, the aims of the present proposal are: 1. to improve exposure assessment to particles in Europe by assessing the size distributions, including ultrafine particles, and elemental compositions of fine particles in ambient air in three European cities with different sources of particulate air pollution 2. to improve risk assessment of exposure to fine particles of differing sizes and of differing elemental composition with focus both on respiratory and cardiovascular outcomes. Workplan: In all three cities, 50 elderly person with chronic cardiopulmonary disease will be followed up for 6 months with biweekly intensive clinic examinations, which include measurements of cardiopulmonary function (spirometry, ECG monitoring, blood pressure) and of biomarkers for lung damage from urine. The subjects will also keep daily symptom diaries and do daily measurements of peak expiratory flow. Concurrently with the panel study, particle number and size distributions and levels of other pollutants in am