RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project '0ptimisation of monitoring for internal exposure' (OMINEX).

assistant: **Concept**

A nuclear industry worker may receive radiation doses either from external exposure, or from internal exposure (e.g. from inhaled radionuclides). The costs of monitoring of internal exposures in the workplace are usually significantly greater than the equivalent costs for external exposures, and there is therefore a need to ensure that resources are employed with maximum effectiveness. This project will develop methods that could be used to optimise the design and implementation of internal exposure monitoring programmes. Current monitoring programmes will be critically reviewed, the major sources of uncertainty in assessed internal dose investigated, and guidance formulated on factors such as programme design, choice of method/techniques, monitoring intervals, and measurement frequency. The result should be a common approach to the design and implementation of internal dose monitoring programmes throughout the EU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Survival response to global change among tetrapods'.

assistant: **Innovation**

General background – Global change is at the centre of the alarming declines of many tetrapod species, especially ectotherms (amphibians and reptiles). To date, however, the demographic processes underlying the global declines of tetrapods as a whole, and ectotherms especially, remain poorly understood, limiting our ability to quantify, predict, and manage extinction risks. Gaps and challenges – Global change factors (climate, habitat degradation) are likely to have major deleterious effects on vital rates such as adult survival, a key parameter in population dynamics and a strong predictor of species extinction risk in endotherms. Yet, our understanding of these processes across tetrapods remains limited, mainly because demographic data on ectotherms have long remained scarce and disparate. Aims of the project – In ECTOGLOB, I will (1) develop the ECTOLIFE web platform, an open-access tool for storing, preserving, and promoting the use of demographic data on amphibians and reptiles; (2) assess how adult survival predicts demographic resilience and extinction risks of tetrapods in general, and ectotherms more specifically; and (3) analyse how the thermoregulatory mode mediates the influence of climate and human footprint on adult survival, expecting more severe impacts in ectotherms. Methods – The project builds on my past research, relying on the ECTOLIFE database that I have developed over the last 8 years. ECTOLIFE compiles longitudinal and transversal data from 1,555 populations of 527 species of amphibians and reptiles worldwide. Using adult survival estimates from ECTOLIFE data and those of endotherms from published studies, I will conduct large-scale comparative analyses, taking advantage of key methods developed by my host and secondment. Projected impacts – ECT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dirac cold-source transistor technologies towards attojoule switching' (AttoSwitch) targeting Horizon Europe.

assistant: **Abstract**

Global energy demand for information and communication technologies may reach up to 20% of total energy by the end of the decade. Innovations on transistor technologies, following Moore’s law, can in part compensate for this rise and improve sustainability by providing more energy-efficient electronics. However, the energy-efficiency of CMOS is limited by the Boltzmann physics, which sets a lower bound on the operating voltage, and thereby the power. To sustain miniaturization, and improved performance of electronics, new transistor technologies are needed that can overcome this limit.AttoSwitch will develop a novel cold-source transistor technology that uses the intrinsically cold carrier distribution of Dirac semimetals to overcome the Boltzmann limit. The main objective is to develop a scalable Dirac transistor technology based on large-area integration of 2D and 3D Dirac materials, e.g. graphene and CoSi, and the realization of high-performance device demonstrators at technologically relevant length scales. Key demonstrators are based on graphene integrated with MoS2 and WSe2 channels, as well as novel work on 3D Dirac semimetals. Our methodology includes development of device process modules and extensive material and device characterization. Systematic modeling using new simulation frameworks plays a key part to benchmark and provide a road map for the technology. Our ambitious performance targets include a subthreshold swing of 35 mV/decade and a switching energy of 4 attojoule.The project links to ongoing European efforts, such as the 2D-experimental pilot line, and the goals set by the European Chips Act. AttoSwitch will impact the semiconductor supply chain at the technology and materials levels, and provide ultra-energy-efficient transistors for logic and hig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'A Flexible Interactive Reading Support Tool'.

assistant: **Innovation**

The FIRST project uses innovative language technology to simplify documents for people with Autism Spectrum Disorders (ASD). These people can have problems when reading such as difficulty understanding complex instructions, misinterpreting literal meanings, or being confused by uncommon words, figures of speech and lack of precision.<br/>Using the language technology created in the FIRST project, users with ASD can convert a standard document into a personalised version which is easier for them to understand. The conversion software will automatically detect problematic language and replace it to make the text clearer. It will also simplify complex structure in the text and clarify ambiguity. Not relying purely on textual changes, the conversion software will add illustrative pictures to documents and will also offer navigation tools such as hyperlinked tables of contents and concise document summaries. Users with ASD will thus be empowered to read any documents with confidence and at their own convenience, without relying on support workers as can currently be the case. This will enable users with ASD to gain better access to educational, vocational, cultural and social opportunities in Europe.<br/>Clinicians in three different EU countries will work closely with a test group of people with ASD, who will review the software and provide feedback to ensure that it is developed to meet their requirements. Tests of reading comprehension with and without the software will provide an explicit indication of the software's advantages.  The involvement of a European support group for people with ASD will allow news of the software to be easily distributed to those who could benefit from it.<br/>An exciting aspect of FIRST's research is that the simplifying language technology t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Spatiotemporal, near-infrared light controlled carbon monoxide delivery for cancer immunotherapy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Carbon monoxide (CO) is a gaseous signaling molecule naturally produced by the human body. In recent years, CO has shown its anti-inflammatory and immunomodulatory properties and thus therapeutic potential in the treatment of inflammatory disorders and cardiovascular diseases. It is promising to exploit the modulatory effect of exogeneous CO in tumour microenvironment where inflammation and angiogenesis are the critical components of tumour progression and metastasis, which is largely unexploited. For this purpose, it is key to manipulate CO exposure in a precise dose and time-controlled manner exclusively at the tumour site. Herein, we propose to develop a new CO delivery avenue, enabling controlled CO release to tumour sites with spatiotemporal precision by using near infrared light (NIR). Specifically, the strategy consists of single-walled carbon nanotubes (SWCNTs) loaded with CO releasing molecules (CORMs). We have reported the development of a SWCNTs-based bifunctional system that enables intratumoural protein delivery and NIR activation, which is ready to be applied to realize controlled CO release in vivo. We plan to conjugate [ReBr3(CO)3][NEt4]2 to SWCNTs. The rhenium complex is chosen because of its stability and non-toxicity while the lipid functionalized SWCNTs have shown biocompatibility, ultrahigh tumour uptake and relatively fast clearance and excretion from the health tissues, which impart the platform promising for in vivo application. We will evaluate the stability of the platform, followed by the NIR-triggered CO release profile and then dose- and time-dependent effect on both cancer cells and tumour-infiltrating immune cells, including the generation of reactive oxygen species (ROS) and expression of multiple genes associated with tumour progress. Fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Boosting productivity and performance in drug discovery with SEQUOIA - Semantic Query of Information Assets' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Synapse Information (UK) have developed a novel semantic web technology, SEQUOIA – Semantic Query of Information Assets – allowing users to rapidly question > 100 disparate data assets in a code-free spreadsheet environment. Having proved the core platform functionality within the financial sector, Synapse now seek to apply SEQUOIA to the field of drug discovery R&D. New drugs are required urgently to treat cancers & other rare/neurological diseases. However, costs and timescales of drug development are huge due to high failure rates. A principle barrier is the lack of real time comparison of disparate datasets, which can identify causal correlations behind reactions throughout the R&D process. Building on the prototype kernel solution, SEQUOIA targets the many high performance silos of public online drug R&D data, enabling all researchers to semantically probe these ontologies against internal R&D. Synapse therefore aim to catalyse a strategic 10 - 100× productivity gain during the discovery phase to disrupt the €5.5 billion/yr drug discovery software market. The overall project aims to: fulfil the further technical developments required to transfer SEQUOIA into priority sectors within drug R&D; initiate the technical and commercial partnerships with key stakeholders in the pharmaceutical industry; validate performance through extended field trials; establish regulatory compliance; deliver compatibility with key user data environments; and optimise a developed product. The proposed Phase 1 feasibility study seeks to address these requirements through: delivery of an elaborated business plan; prioritised EU market entry strategy; analysis of market-held data assets, technical development roadmap; engagement of key stakeholders in the pharmaceutical industry; supply chai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Innovative End Locker for Efficient Design for Disassembly (DfD) in Concrete Construction'.

assistant: **Concept**

The construction sector is responsible for more than 7 % of the world’s anthropogenic CO2 emissions, primarily due to cement production. The cement production alone accounts for 4 % of CO2 emissions in the European Union (EU). The construction sector is also resource intensive, using billion tons of natural resources and generating billions of tons of construction and demolition (C&D) waste yearly. In fact, approximately 30 % of all waste within the EU comprises C&D waste. To address these challenges and move towards a sustainable society, it is imperative to implement circular economy (CE) principles within the construction industry. A key strategy is to design the structural elements with the ability to disseminate and reuse in different projects, a design approach known as Design for Disassembly (DfD). This project focuses on the design, development, and evaluation of an innovative corrosion-free end locker to enable an efficient DfD in RC structures. By aligning with CE principles, our approach aims to significantly reduce CO2 emissions, minimise waste, and realise cost savings. This venture not only promises a sustainable shift in the construction domain but also propels advancements in material science, structural engineering, and numerical modelling. The project is product oriented, complemented by the development of design guidelines for practical applications of the locker system aligned with a novel construction practice.


**Keywords:** Construction Industry, Finite Element Simulations; Circular Economy; Structural, Design for Disassembly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrating Quality Monitoring into 3D Bioprinting via Light Sheet Microscopy' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

A critical bottleneck in bioprinting hardware is the lack of integrated quality monitoring features for characterising print accuracy and cellular composition during fabrication. This limitation makes it challenging to develop reproducible and standardised bioprinting protocols, which are essential for GMP-compliant production. The lack of integrated quality monitoring also leads to a reliance on destructive, post-printing analysis methods that are incompatible with clinical translation. To address this problem, visionPRINT will develop a 3D bioprinting platform with an optical imaging system and complementary use of Light Sheet Fluorescence Microscopy (LSFM). Unlike current bioprinting hardware systems, visionPRINT will provide volumetric quality assessment of bioprinted constructs. visionPRINT will be the first bioprinting system to offer this level of integrated quality control, and this technological differentiation will help facilitate market adoption as the industry progresses toward standardised protocols and clinical applications.visionPRINT’s integrated data-driven quality monitoring features will transform bioprinting workflows across research, development, and clinical applications. Comprehensive volumetric data logging capturing both construct shape and cell composition will help end users enhance the accuracy and reproducibility of their bioprinting protocols. Furthermore, the technology will make it easier for end-users to standardise protocols and demonstrate GMP-compliant production for regulatory approval. Ultimately, visionPRINT will accelerate the development of safe and functional bioprinted tissues for clinical applications, benefiting patients worldwide.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Member states and coalition building in a wider and deeper European Union' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

The purpose of the proposed research project is to contribute with systematic empirical data to a research field -negotiations and coalition-building in the Council of Ministers of the European Union - which is suffering from too little data to put into existing theoretical models. Current research is strong on formal modelling, but weak on empirical testing. The main empirical puzzle for the project is: Which coalitions are formed, why, and with what consequences? Special attention will be given to effects of the 2004 enlargement. It is assumed that the continuing process of enlargement and deepening of the European Union will put the negotiation system of the Council under increasing pressure. Estimating the effects is difficult, however, because of our incomplete knowledge of how the system works today.This project will contribute to a better understanding of the basic functioning of the most important legislative body of the European Union. It will provide empirical evidence on coalition building and negotiations between member states, both before and after the enlargement of 2004. One survey has already been conducted with negotiators from all member states and a second survey will be carried out in 2005. Qualitative interviews with officials at the permanent representations in Brussels will also be used. Combining the insights from formal coalition-formation theory with empirical research on actual behaviour will be a highly innovative contribution to the field and will open doors to a deeper theoretical understanding of the negotiation system of the Council.The purpose of the mobility period is to strengthen Daniel Naurin's capacity to initiate and manage future international research projects. No research institution is more suitable for research training within
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Biogeographic and cultural adaptations of early humans during the first intercontinental dispersals'.

assistant: **Innovation**

Our understanding of the emergence and dispersal of the earliest tool-making hominins has been revolutionised in the last decade, with sites in eastern Africa and China pushing both events more than half a million years earlier than previously thought. Traditional models linking biological speciation, cultural innovation and migration events with climatic pulses have remained theoretical, and recent discoveries suggest that the picture of the earliest human colonization across the Old World is far more complex, demanding heuristic approaches to understand the biogeography and adaptive behaviours of early humans.This project will be the first substantive attempt to produce a global synthesis of earliest human occupation dynamics by comparing the world’s longest sequences of early archaeological sites, namely eastern Africa and China. Our objective is to understand the alternative evolutionary trajectories adopted by hominins that shared an overarching biological and cultural background, but who faced different climatic and biogeographic challenges and opportunities. The ambition of our global-scale objectives is accompanied by the unmatched quality of our datasets and the ground-breaking perspective we will adopt in their study. Fieldwork in the two most renowned sequences in each region alongside a primary study of additional top-quality assemblages in both subcontinents, will be combined with extensive metadata sets to produce comprehensive views of temporal trends and paleoecological patterns. Our state-of-the-art methodological sets (which combine an exceptionally diverse range of disciplines from geochemistry to niche modelling) and ground-breaking analytical perspective (which considers data from micro-stratigraphy to satellite imaging) will enable us to develop ne