RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Monsoons and climate change: roles of atmospheric and oceanic processes' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Monsoons affect more than half the world’s population yet the dynamics of monsoons are poorly understood. Climate models struggle to accurately simulate monsoons and projections of how these circulations will respond to climate change are highly uncertain. A transformed understanding of monsoon dynamics has the potential to improve both climate models and predictions of how this key feature of the climate system will respond to global warming.This project will use idealised climate-model simulations to quantify the impacts of clouds, water vapour, carbon dioxide, and ocean heat transport on changes in monsoon dynamics. These atmospheric and oceanic processes have recently been shown to affect the Hadley circulation and midlatitude storm tracks, but their influences on monsoons are unknown. To isolate and quantify the effect of each process on the monsoon response to climate change, a novel set of simulations employing the radiation-locking technique and a simple dynamic representation of ocean heat transport will be performed. This reduced-complexity methodology will deliver a greatly improved mechanistic understanding of monsoons under climate change. The enhanced knowledge of monsoon dynamics that results from this project will ultimately lead to improvements in climate models and to better predictions of how monsoons will change in the future, with important benefits for societies around the world.


**Keywords:** Monsoons, atmospheric dynamics, clouds, water vapour, carbon dioxide, ocean heat transport, radiative transfer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Evolution of eukaryotic intron splicing'.

assistant: **Objectives**

Introns are non-coding intervals that interrupt the codingsequences of eukaryotic genes. Intron removal is performedby a complicated molecular machinery, called thespliceosome, concomitantly with gene transcription. Intronsand the splicing machinery (or at least their traces) arefound in every sequenced eukaryotic genome. Moreover, manyintrons are found at homologous positions across differentkingdoms, suggesting that some originate in the earliesteukaryotes.Introns are largely devoid of function, yet  in humans (andmammals in general), they make up more than~40% of thegenome. The most obvious evolutionary advantage of theinterrupted coding sequences is that they increasefunctional complexity by enabling alternate assemblies.Introns provide a powerful source of variations for naturalselection in many other ways, since splicing is tightlycoupled with transcription and export from the nucleus, andintronic sequences frequently harbor regulatory elements.The proposed project aims at developing bioinformatics toolsand mathematical models that help understanding randomnessand natural selection that shape exon-intron architecture indifferent eukaryotic lineages. In particular, we willinvestigate intron turnover in fast-evolving genes,selective constraints on intron length and mechanisms ofintron gain on a large scale, using annotated whole genomes.In addition to providing new insights into the waysevolution affects gene structure, the developedmethods will be useful to produce better annotations ofcoding regions and functional intronic elements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'International Network for Terrestrial Research and Monitoring in the Arctic' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Environmental change and particularly amplified global climate change are accelerating in the Arctic. These changes already affect local residents and feedback from the Arctic’s land surface to the climate system, will have global implications. However, climate change and its impacts are variable throughout the wide environmental and land use envelopes of the Arctic. Unfortunately, the Arctic is generally remote, sparsely populated and research and monitoring activities are more restricted in time and space than elsewhere. This limitation comes when there is a rapidly expanding need for knowledge as well as increasing technological opportunities to make data collection in the field and accessibility more efficient. INTERACT is a network under the auspices of SCANNET, a circumarctic network of terrestrial field bases. INTERACT specifically seeks to build capacity for research and monitoring in the European Arctic and beyond. Partnerships will be established between Station Managers and researchers within Joint Research Activities that will develop more efficient networks of sensors to measure changing environmental conditions and make data storage and accessibility more efficient through a single portal. New communities of researchers will be offered access to Arctic terrestrial infrastructures while local stakeholders as well as major international organisations will be involved in interactions with the infrastructures. This will lead to increased public awareness of environmental change and methods to adapt to them, increased access to information for education at all levels, and input to major international research and assessment programmes.The whole consortium will form a coherent and integrated unit working within a concept of a wide environmental and land use enve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Nuclear Decommissioning Training Facility' (EUNDETRAF), addressing dissemination and exploitation.

assistant: **Impact**

EUNDETRAF is a training course similar to the Euro-courses, with the objectives to centralise the European know-how and to transfer it to third parties. These two objectives meet the wish of the European Commission for centralising know-how and is also an answer to a high request of training. The proposal covers three years with the main objective to give a yearly course by European Decommissioning experts. The course exist out of a one week theoretical course and a two weak practical training. The theoretical part is for a broadaucience, the practical part is for selected persons. The training target group are owners, regulators and waste management agencies. Participation will be done by paying a training fee. In some cases, the participant can use support from other EC directorates to pay their contribution.The main objectives of the project are as follows:- To centralise and to keep up-to-date the European decommissioning know-how on an European level;- To stimulate the transfer of knowledge to come to a global approach of the decommissioning problems;- To strengthen the position of the European decommissioning industry on an international level;- To transfer the existing know-how in an efficient way to those institutions or organisations who need the latest techniques in decommissioning.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nanomaterials for treatment of neurodegenerative disorders' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Development of new strategies to treat neurodegenerative diseases is one of the key priorities of the European Union. Their socioeconomic burden is rapidly growing due to the increasing lifespan and the decreasing percentage of working population, currently costing the EU €130 billion a year in care.Despite efforts put in development of treatments for neurodegeneration, the bench-to-bedside translation of neuroprotective strategies remains very low. Major factors contributing to this problem are incomplete understanding of the mechanisms behind neuronal injuries, lack of compounds affecting multiple protective pathways/cell types, and side effects caused by broad-spectrum neuroprotectants. A separate crucial problem is the limited blood–brain barrier (BBB) passage of most compounds. Therefore, identification of effective therapeutic targets in the brain and delivery of novel low-cost neuroprotectants with minimal side effects and high BBB passage is of paramount importance.The emergence of nanoneuroscience is revolutionizing treatment of CNS disorders. This approach uses nanometer-scale materials, which can interact with biological systems at a molecular level, bypass cellular barriers and induce desired physiological responses in cells with minimal side effects. The project proposed here combines advanced methods of nanoscience and neurobiology to (1) characterize novel therapeutic targets and neuroprotective pathways in the brain and (2) design novel efficient nanoprotectants against neurodegenerative conditions, such as stroke, epilepsy, Parkinson’s and Alzheimer’s diseases.The project will offer exemplary training for the Fellow in nanoneuroscience, as well as in project management skills, at Imperial College, ranked the 5th highest university internationally. These
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Targeted Respiratory Drug Delivery by Tribo Charged Sprays' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The main purpose of this proposal is to develop a radically new technology for very precisely delivering medicine to the human body. Targeted deposition of drug formulations to the lungs exhibits great promise in several treatments, e.g. siRNA treatment against lung cancer or mRNA vaccination against COVID-19. This requires oral and nasal inhalation for which spray pumps and nebulizers are widely used to transform an aqueous formulation into a soft mist spray. However producing the necessary drop size is hampered by droplet coalescence, making drops too large and polydisperse; because of this, they deposit in the wrong places. Large droplets between 10 and 50 micrometers deposit mostly in the upper respiratory tract (mouth, throat or nasal cavity) through ballistic impact on the mucosal tissue, whereas small droplets between 5 and 10 micrometers can be lifted by the airstreams and deposit mostly inthe lower respiratory tract (bronchi and lungs). Our innovation relies on the charging of drops through the friction with the nozzle material. The charged drops repel and do not coalesce, allowing precise control of their size to target e.g. the lungs. This allows to achieve safe and effective targeted deposition of drugs and /or vaccines with hitherto unequaled precision.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sizes Matter: The Dust Size Distribution during Planet Formation' in the context of a Horizon Europe call.

assistant: **Objectives**

Planets form in discs of gas and dust around young stars. Within these discs, micron-sized dust particles need to clump together to grow 14 orders of magnitude to form Earth-like planets as well as the cores of giant planets. It is a major challenge to understand dust growth from start to finish. State of the art observations provide spectacular glimpses of the dust distribution at a limited range of sizes: ALMA produces images of the thermal emission of mm-sized dust, while instruments such as SPHERE probe the distribution of much smaller particles. However, for a comprehensive theory of planet formation, we need to understand the process from start to finish, from micron-sized to planet-sized. This is therefore the story of the dust size distribution: how many dust specks, pebbles and boulders are present? While there are large size ranges that are out of reach observationally, in this project we will exploit the fact that all dust sizes are coupled to the gas via friction to take a panoptic view of the size distribution for the first time. Since the gas feels friction from all dust sizes, the size distribution is encoded in the gas kinematics, and therefore in every single dust size as well. We will perform hydrodynamical simulations including the full dust size distribution to write the polydisperse story of planet formation. We aim to reconstruct the full size distribution from sparse observations, thereby avoiding the need for expensize multi-wavelength observations. We will compare dust and gas distributions with observations of protoplanetary discs as well as the composition of Solar system bodies. We will use a novel numerical method that allows us to perform these computationally expensive simulations, and employ machine learning to speed up the calculations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Reduction of fouling and pressure losses through gas reheaters using optimised enamelled and mesh plastic composite heat' to be submitted under Fifth Framework.

assistant: **Abstract**

It is proposed to determinate the benefits arising from the replacement of the cold-end layers in a pair of rotary regenerative gas re-heaters in a UK Power Station with optimised profiles of both glass enamelled and mesh plastic composite (MPC) elements. The pressure drop and fan power savings made by these new elements will be compared to that the present elements over 1 year of operation using the station TMs Operating Information System to gather the operating data. The pressure drop drift will be studied on each heater to determine the influence of specific operating conditions and alternative cleaning measures. Associated specific investigative work may also be required. The innovative nature of the work is particularly associated with MPC elements. However, the redesign and replacement of the element profile to optimise performance for both sets of elements should result in an additional, significant power saving. Therefore, this is also an important feature of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The positive and normative aspects of corruption' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content Agents in a hierarchy, due to their expertise, are commonly delegated authority to take decision and report information. While delegation reduces the burden of communication and information processing on the principal, it also introduces additional incentives problems. Corruption arises when a member of the organization uses the discretion confered on her to help another agent at the expense of the organization. This research raises the general question whether and how a principal (the owner of the organization, say) would want to regulate these non-desirable" side-exchanges taking into account that this may hurt the realization of "desirable" side-exchanges (like mutual cooperation). The research seeks also to explain the detrimental effects of corruption as well as its extent and persistence in a dynamic perspective. The main novelty of this research is that we shift the emphasis to the organization design and the transactions costs of side-contracting. Training content (objective, benefit and expected impact) See the note on the description of the host institution and the group which will host the candidate. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on '4th International symposium on electrocatalysis: from theory to industrial applications""'.

assistant: **Concept**

The 4th International Symposium on Electro catalysis: From Theory to Industrial Applications" will be held in Como (Italy), 23-25 September 2002. The organization is under the auspices of the International Society of Electrochemistry (ISE), the International Association for Hydrogen Energy (IAHE), the Italian Chemical Society (SCI) and the University of Milan.The meeting is devised to survey recent advances in theory and fundamentals, as well as in practical applications and industrial implementation of electro catalysis in all areas of electrochemistry from fuel cells (with special attention to low temperature mobile devices) and batteries to electrolysers and sensors, from organic electro synthesis to pollutant abatement processes. Emphasis will be placed on the effect of the electrode material and its (nano) structure.The aim is to bring academic and industrial researchers together to achieve an exchange of experience and ideas, so as to promote further advances in the research and development of materials for electro catalysis. Topics will include H2, 02, Cl2 evolution and ionisation, oxidation of organic and inorganic pollutants, kinetic aspects, effect of adsorption, surface science aspects, synthesis and characterization of materials, etc.The meeting will last three full days and will consist of invited lectures (3 plenary and 24 keynote), oral and poster contributions. Reports on posters are also planned. A special issue of Electrochimica Acta, the official journal of ISE, is planned (publication 2003). An exhibition of scientific instruments and books is being considered.Como, the birthplace of Alessandro Volta is on the international railway line connecting Milan to Northern Europe via Zurich or Basel and close the Malpensa International Airport. The meeting w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Engineering biological timers and their applications' (2021-2027).

assistant: **Concept**

Living cells are endowed with encoded programs that allow them to execute vital tasks and respond to relevant stimuli. The use of analogous (synthetic) programs has an enormous potential, yet we are highly limited in our ability to program cellular actions over time. We rely on precisely-timed human intervention or on molecular oscillators that control repetitive processes, but we are still unable to program cells to autonomously execute custom actions at desired times.I now intend to make a big leap toward this goal by producing control systems (molecular timers) and associated, ready-to-use applications, for the precise and self-sufficient control of cellular actions over time. Specifically, I will engineer timer gene circuits into E. coli that compute time and perform desired actions at specified moments. Timers will be highly programmable, re-usable, and scalable, and I will exploit their potential by using them for different applications, including bioproduction and biosensing.In sum, I will develop the highly-needed, ground-breaking ability to measure and program time in cells. My results will unleash a myriad of new possibilities, both fundamental and applied.


**Keywords:** synthetic biology, gene circuit, CRISPRi circuit, dynamic circuit, molecular oscillator, molecular clock, molecular timer, cell programming, biocontainment, biocomputing, molecular recording
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'XIX International Conference on Magnetic Resonance in Biological Systems' in the context of a Fifth Framework call.

assistant: **Objectives**

This is the XIX edition of this biennial series of conferences and is jointly organized by the three European Large Scale Facilities on magnetic resonance (Florence, Frankfurt and Utrecht). This conference intends to cover all aspects of magnetic resonance in the life sciences, a field undergoing a great expansion, both qualitatively and quantitatively, and attracting more and more attention from governments and research funding agencies. The following topics will be covered: protein structure, folding, and dynamics; solid state NMR and membrane proteins; high field ENDOR and high field EPR; NMR spectroscopy and technological advancements (quadrupolar nuclei, paramagnetic NMR, DNP, relaxometry, high field effects in NMR); in vivo spectroscopy and imaging; DNA, RNA, and nucleotides and their interaction with proteins; structure-activity relationship and drug discovery; computation and dynamics; related techniques. An International Advisory Board helps the organizers to select topics that are timely and have future promise. Particular attention will be devoted to new and promising areas of research as well as to emerging methodological tools.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00069-1.pdf