RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Surfaces, 3-manifolds and automorphism groups' (2-3-AUT), addressing dissemination and exploitation.

assistant: **Impact**

The scientific goal of the proposal is to answer central questions related to diffeomorphism groups of manifolds of dimension 2 and 3, and to their deformation invariant analogs, the mapping class groups. While the classification of surfaces has been known for more than a century, their automorphism groups have yet to be fully understood. Even less is known about diffeomorphisms of 3-manifolds despite much interest, and the objects here have only been classified recently, by the breakthrough work of Perelman on the Poincar\'e and geometrization conjectures. In dimension 2, I will focus on the relationship between mapping class groups and topological conformal field theories, with applications to Hochschild homology. In dimension 3, I propose to compute the stable homology of classifying spaces of diffeomorphism groups and mapping class groups, as well as study the homotopy type of the space of diffeomorphisms. I propose moreover to establish homological stability theorems in the wider context of automorphism groups and more general families of groups. The project combines breakthrough methods from homotopy theory with methods from differential and geometric topology. The research team will consist of 3 PhD students, and 4 postdocs, which I will lead.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Marine Algae as Biomass for Biofuels' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Currently most research into efficient algal-oil production is being carried out by the private sector, but if predictions from small scale production experiments are realised then using algae to produce biodiesel may be the only viable method by which to produce enough bio-fuel to replace current world petrol/diesel usage. Micro-algae in particular have much faster growth-rates than terrestrial crops. The yield of oil from algae is estimated to be from between 19,000 to 75,000 litres per acre, per year; this is 7 to 31 times greater than the next best crop, oil of palm. As terrestrial contributions are greatly limited by the finite area of land available under any culture method, it is essential that the potential of the marine environment as a source of biomass for bio-fuel production is realised. The group intends to facilitate a multi-disciplinary research programme through the recruitment of experienced researchers aimed at the acquisition of new knowledge and skills in the production of biofuels from native seaweed and cultured micro-algae. The project will identify the native seaweed and cultured micro-algal processes with the most potential for fuel production, the best time and technique to harvest seaweed and the culture methodologies for micro-algae along with an economic and environmental appraisal which will identify the size of the farm required and the feasibility of a commercial size operation. This will provide the physical (biomass product) and the intellectual (methodology for production and extraction) tools to enable the bio-fuel sector to base it’s business on the most suitable and profitable process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Self-assembly of DNA-coated colloidal particles' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This project aims to use computer simulations to elucidate the structural properties and the phase behaviour of DNA-coated colloids. Several parameters, such as the shape and size of the colloids, the length and flexibility of the grafted DNA, and the number of DNA strands per colloid influence the equilibrium properties of these materials in ways that are, as yet, poorly understood. The applicant, Dr. Mladek, intends to use Monte Carlo simulations to predict the structure and phase behaviour of DNA-coated colloids. To this end she will adapt existing simulation techniques (e.g. umbrella sampling, configurational bias Monte Carlo and thermodynamic integration) to this specific problem. Where necessary, novel MonteCarlo techniques will be developed. It is expected that the proposed project will provide insights that can assist experimental work on the self-assembly of these materials which have many potential technological applications (for instance as photonic band-gap materials). As a first aim, the applicant will explore how DNA-coated colloids can best be designed to serve as building blocks for the self-assembly of non-trivial crystal structures. In this project, the applicant aims to maintain close contacts with the relevant experimental groups, both at the host institution and elsewhere.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'State Capacity and Development' in the context of a Horizon Europe call.

assistant: **Objectives**

State capacity — the ability of the state to raise revenue and provide public goods — is considered essential for economic development. This ability is still lacking in many developing countries today, and important lessons can be drawn from countries that have been successful in developing an effective state in the past.The over-arching goal of STATE-DEV is to advance our understanding of the development of state capacity, with particular emphasis on three essential pillars: 1) the drivers of demand for state capacity; 2) the quality of the state's bureaucracy, a crucial element of the supply side of state capacity; 3) the institutional elements that facilitate or hinder corruption in the operations of the state.To reach this goal, I undergo large data collection efforts to assemble groundbreaking new data mapping the presence of the state across space and time in two historical settings – Italy and the United States between the second half of the 19th century and the first half of the 20th century – characterized by a rapid growth in the size and reach of the state. By leveraging historical natural experiments, the proposal establishes causal relationships and sheds light on the mechanisms shaping the evolution of state capacity over a long time horizon.STATE-DEV is composed of three projects. Project 1 investigates the factors affecting citizens’ demand for more state presence in their community, focusing on the role of technological change and of immigration. Project 2 studies the impacts of individual bureaucratic leaders on the evolution of state capacity and economic development. Project 3 analyses the effects of the revolving door between the bureaucracy and the private sector on firms’ dynamics in the short and long run.STATE-DEV speaks to economists, political
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Eco efficient activation for hyper functional surfaces' (ACTECO), addressing dissemination and exploitation.

assistant: **Impact**

The objective of this IP is to support the less RTD intensive sectors of textile, biomedical and food industries in the development of more sustainable and safer processes through eco-innovation (new products and production systems). Plasmas are studied si nce years, but the main problem faced by this technology is the durability of the treatment. This project involves new plasma processes that are able to bring innovative properties with a lifetime close to the final products' one. This breakthrough will be achieved by developing existing knowledge in plasma processes and functional materials in combination with new plasma systems for nanotechnology. The ACTECO project will : - contribute to the modernisation of the industry and to the adaptation to the new economy, - substantially improve overall quality within the value chain, - minimise waste, use of hazardous substances and resource consumption. In this context, ACTECO addresses the objectives of the 3.4.3.3.1 workprogramme of the call. The objective-driv en approach is mainly focused on new products by reaching hyper functional surfaces in association with the use of new plasma processes. The radical innovation is to provide new tools for an eco-production adapted to traditional sectors. The first phase of the workprogramme is related to Research at laboratory scale on the development and optimisation of the surface modification processes in constant interaction with an Equipment development activity. The second phase is focused on Applied Research by optim ising existing prototypes at pilot scale. The new processes will be then developed through pre-industrial applications comparing the several facilities involved in the project (real devices and real environment). Both phases will be driven and monitored by mark
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Search for ms neutral higgs bosons with the Delphi detector at Lepii' (1994-1998).

assistant: **Concept**

The objective of this project is to look for neutral MSSM Higgs bosons using the DELPHI detector in the LEPII accelerator at CERN. Since June 1996 LEP will produce data at a center of mass energy increased from 91.2 to 161 GeV (with further upgrades up to 205 GeV) which will allow to extend the search of these particles -with present lower mass limits at 95% CL of mh > 45.4 GeV/c2 and mA > 45.2 GeV/c2- to higher masses (up to 100 GeV/c2 for certain choice l of MSSM parameters) Pair production of hA Higgs bosons give a final 4b jet topology. B jets will be tagged using the new extended 3D microvertex detector and their mass reconstructed using the improved hermeticity | capability of DELPHI. Candidates will be studied in greater detail using 3D graphical scanning techniques. Training content (objective, benefit and expected impact) This work will be made amongst first line experts in MSSM Higgses as well as in b-tagging and | mass reconstruction techniques. This experience could be transferred back to the origin laboratory in Spain. The results of this project will determine the feasibility of the MSSM theory, either excluding a big | fraction of the parameter range or giving a big step forward in the understanding of nature, should the existence of these particles be confirmed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanical Testing and Analysis of innovative Prepreg Systems' (MAPS) under Seventh Framework.

assistant: **Objectives**

The aim of this work is the complete characterisation of innovative prepreg systems based on carbon fibres and nanoparticle modified resins. After the test specimen production well known and long time approved mechanical test methods related the aircraft industry, as well as thermo-mechanical and chemical analyses will be used for the characterisation. Regarding the fibre-matrix adhesion a novel test method will be developed which is based on a tensile test for single fibres. Considering the long time experience in harmonising test methods for fibres and the experience of testing single natural, synthetic and high performance fibres a pull out test with a so called Dia-Stron equipment will be feasible resulting in a very simple and standarised test method to determine the fibre matrix adhesion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'B-specific: B-cell related gene and protein markers with prognostic and therapeutic value for CVD' (B-specific).

assistant: **Innovation**

Atherosclerosis is the major underlying condition of cardiovascular disease (CVD) and one the leading causes of mortality. Rupture or erosion of atherosclerotic lesions can lead to acute cardiovascular events, such as myocardial infarction and stroke, making biomarkers to diagnose patients at risk for these events and develop tailored preventive interventions, an urgent need. Although atherosclerosis is a chronic inflammatory disease, clinical investigation of the adaptive immune system as a potential rheostat for disease development has been limited. The B-specific consortium aims to classify and mitigate risk of CVD by generating novel types of genetic data and defining novel prognostic and therapeutic targets attained from our recent discovery of a specific B-cell subset. We will employ state-of-the-art technology, including single cell RNA sequencing, BCR repertoire analysis and mass spectrometry-based identification of autoantigens in CVD patient material. With access to large population-based cohorts (FIMCOD, ERGO Study) spanning healthy adults of 40-105 years of age, we aim to assess the prognostic value of circulating B cell subsets and antibodies in (sub)clinical atherosclerosis and investigate the contribution of genetic disposition. Using the extensive genomics data of the ERGO Study, we will be able to determine causal links between the prognostic indicators and disease progression by applying Mendelian Randomization experiments and confirm these relationships in ex vivo and in vivo models of atherosclerosis. Based on these findings, B-specific aims to develop at least 1 proof-of-concept therapy targeting specific B cells. B-specific will implement an active open science platform and in combination with a targeted dissemination approach to healthcare profess
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Characterisation of phosphofructokinase and pyruvate kinase of leishmania. Potential targets for new drugs'.

assistant: **Innovation**

* To study the structure and kinetics of phosphofructokinase (PFK) and pyruvate kinase (PYK) of Leishmania, key enzymes in the metabolism of the parasite, and to determine differences with the corresponding mammalian enzymes.* To design and synthesize selective inhibitors of the Leishmania enzymes, based on their differences with the mammallian enzymes.Expected Outcome* The primary structure of Leishmania PFK and PYK will become available.* The enzymes will be overexpressed in a heterologous system and purified.* Kinetic parameters of the enzymes will be established.* Preliminary information on the structure of the enzymes will become available.* Compounds with (some) inhibitory activity on the Leishmania enzymes will be synthesized.* Cloning and sequence determination of the Leishmania PFK and PYK genes.* Overexpression of the Leishmania enzymes in bacteria (Escherichia coli) or yeast (Hansenula polymorpha).* Purification of the recombinant enzymes.* Kinetic analysis of the purified enzymes.* Structure modelling of the Leishmania enzymes, using the X-ray coordinates of the crystal structures of homologous enzymes.* Structure-function analysis of residues potentially important for inhibitor design by site-directed mutagenesis.* Crystallization trials of recombinant Leishmania PFK and PYK.* Synthesis of potentially selective inhibitors of Leishmania PFK and PYK.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SELF-ASSEMBLY POLYMERIC NANO-BIOMATERIALS FOR DRUG DELIVERY AND TARGETING' (NANOTAR).

assistant: **Innovation**

The present plan aims to build up and consolidate a research program in Pharmaceutical Nanomaterials Science based on the design, synthesis and chemical characterization of novel self-assembly polymeric nano-biomaterials and the investigation of the relationship between the nano/microstructure and the properties and new processing methods for the improvement of the biopharmaceutic performance of drugs. While the long-term goal of my research plan at the Technion is to develop versatile platforms for various therapeutic applications, the present proposal is oriented to make a substantial contribution to improve the treatment of two infectious diseases, the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and tuberculosis (TB), by developing innovative products that overcome important limitations of the products currently on the market such as poor oral bioavailability and frequent administration. The emphasis of the proposal is on the design, synthesis, processing and comprehensive characterization of the nano-biomaterials and the preliminary assessment of their biological performance in vitro and in vivo. It is a mid-to-long term of this proposal to facilitate the integration of my new research group to a multidisciplinary European network that will address challenges in HIV and TB.The specific aims of the proposal are the development of three types of novel self-assembly nano-biomaterials and the preliminary characterization of the in vivo performance of the systems with optimal properties:Aim 1-Development of alkoxysilane-grafted polymeric amphiphiles.Aim 2-Development of polymeric amphiphiles conjugated with mono- and oligosaccharide residues.Aim 3-Development of muco-adhesive polymeric micelles.The different drug delivery systems are planne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cost-efficient, solid-state refrigeration technology for cold storage' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Vapour compression (VC) technology, used in the vast majority of space cooling and food refrigeration applications, currently relies on synthetic refrigerants which are either ozone depleting substances or mixtures with global warming potential. For this reason, their use is being downsized by EUs F-gas legislation. There is an urgent need to either retrofit existing VC systems and replace banned refrigerants with natural fluids such as ammonia, carbon dioxide (CO2) or hydrocarbons (which are toxic, flammable or costly), or adopt new technologies. On top of that, not all natural refrigerants are suitable for cold storage applications in the range of 1-10kW, where an accurate temperature (T) control and reduced food weight loss is crucial for quality food preservation. CO2 vapour compression (CO2VC) is currently the best option even though it is not safe (CO2 leaks), not so precise in T control and food weight loss is noticeable. An alternative cooling technology that could replace CO2VC for this particular application could be state of the art solid-state technology if low power and high cost did not impede this technology to go mainstream.Integrate is a belgian start-up that has managed to avoid the use of refrigerant gases and overcome current technology (CO2VC and state of the art solid-state technology) limitations in cold storage applications by developing SolidCool. SolidCool is a solid-state solution that can be used for high-power applications with the benefits of presenting a high accurate T control, a minimum food weight loss, 50% less total cost of ownership, 40% lower price than CO2VC, and can function on solar energy. Given the need to phase out the use of pollutant refrigerant fluids, Integrate is capitalizing on an immediate, global opportunity for indust