RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'RI services to promote deep digitalization of Industrial Biotechnology - towards smart biomanufacturing' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Industrial Biotechnology (IB) is a Key Enabling Technology for the circular bio-economy, industrial renewal and European manufacturing autonomy. Its development forms a vital part of EU’s strategy to become climate neutral in 2050. For IB to become a major manufacturing technology, it must widen its use of advanced digital technologies. These will improve R&D efficiency, reducing time-to-market and costs. Moreover, for manufacturing, advanced digital technologies will drive distributed, autonomous and highly adaptable production systems. To support digitalization of IB, BIOINDUSTRY 4.0 will create new services delivered by European research infrastructures (RI). These services will address several challenges, focusing on the acceleration of bio-process development pipelines. Drawing on the complementary skills of its consortium, BIOINDUSTRY 4.0 will develop data-driven approaches, exploiting AI to empower novel decision support systems and digital twins, the latter being to better design bio-processes and enable their real-time online control. To complete these services, BIOINDUSTRY 4.0 will also develop data and metadata standards to generate high quality, interoperable multi-scale bio-process data, the technical basis for trusted data networks and process analytical devices to provide real-time online monitoring of bio-processes. Once deployed, these RI services will provide Users with access to cutting-edge technologies that can be used singly or in an integrated way, covering whole R&D pipelines. Integrated services will be delivered by a distributed RI, conferring Europe with a unique R&D test-bed for bio-process development and a competitive advantage with respect to global competition. To succeed, BIOINDUSTRY 4.0 brings together 6 EU RIs, 1 global company, 2 inno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'ANTIBODY DERIVATIVES AS MOLECULAR AGENTS FOR NEOPLASTIC TARGETING'.

assistant: **Concept**

The selective delivery of bioactive agents (cytotoxics, radionuclides, cytokines) at the tumor site, while sparing normal tissues, represents one of the most promising avenues for the development of anticancer therapies with unprecedented efficacy and tolerability. Monoclonal antibodies represent the preferred vehicle for the targeted delivery of bioactive agents to cancer sites, as they can display a preferential accumulation in primary and metastatic tumor lesions already few hours after intravenous administration. Certain monoclonal antibody derivatives can remain on the neoplastic mass for several days, thus enabling the slow release of potent cytotoxics or the continuous action of bioactive agents such as cytokines or therapeutic radionuclides. The ADAMANT Project aims at the generation of anticancer agents of superior quality, which rely on the antibody-based delivery of cytotoxics, radionuclides or immunostimulatory cytokines to either vascular tumor antigens or to tumor cell membranes. While clinically-validated antibodies will allow the rapid development of therapeutic strategies based on novel antibody derivatives, innovative perfusion-based chemical proteomic technologies will facilitate the discovery of accessible and abundant tumor-associated antigens, ideally suited for the targeted delivery of bioactive agents to cancer sites. Imaging methodologies will guide us in the selection of antigens, antibodies and therapeutic agents with optimal pharmacokinetis and pharmacodynamics. Finally, therapy studies in tumor-bearing mice, featuring the use of antibody-derivatives in combination with other anti-cancer drugs (cytotoxic, biological, vascular disrupting agents) will provide insights about how to best translate the results of the ADAMANT Project to clinical de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Function and dynamics of Lmo4-containing complexes during erythropoiesis' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Anemias and erythroid malignancies caused by impaired formation of erythrocytes (red blood cells) are common disorders. These diseases have a severe impact on the quality of life of the patients. It is essential to unravel the molecular mechanisms underlying erythropoiesis (the development of red blood cells) to be able to fully understand the etiology of these diseases and to devise novel treatments. The most important part of understanding the molecular mechanisms of erythropoiesis is the unraveling of its transcription factor network and studying how this network responds to outside signals. I propose to analyze the function and dynamics of this network through a study of the factors that are part of the Ldb1/Gata1 complex, and in particular the function of the LMO4 protein.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced remote sensing methods for global ecosystem characterization' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Specific Objectives:1. To support users of environmental information by providing relevant, reliable and accurate characterizations of the state and evolution of terrestrial environments over regions of interest and for a multi-year period;2. To support national and international Space Agencies in their efforts to generate useful products and to design future instruments that will meet the evolving requirements of the user community, in line with the developing GMES priorities;3. To conduct research and development activities leading to quality and accuracy assessments as well as benchmarks of the tools routinely used in remote sensing;4. To advance the state of the art in remote sensing research and prepare new advanced techniques that will be required to take full advantage of the next generation of sensors. Anticipated milestones and schedule.The following milestones are indicative of current plans for 2003: By the end of the second quarter of 2003: - Compile a database of boreal forests characteristics (Deliverable 4.1). - Document the status of the archiving system (Deliverable 1.3). - Submit the RAMI Phase-2 manuscript (Deliverable 3.2) for publication in the refereed literature. By the end of the third quarter of 2003: - Report to ESA on the reliability and accuracy of the FAPAR product derived from MERIS on ENVISAT (Deliverable 3.1). -Make available 3 years of monthly FAPAR products over Europe (Deliverable 1.1) and 1 year of monthly FAPAR products over the globe (Deliverable 1.2) to the CarboEurope network of projects. By the end of the fourth quarter of 2003: - Deliver draft of MSG surface albedo ATBD to EUMETSAT (Deliverable 2.2).Planned Deliverables:1.1 Monthly composite FAPAR products over Europe at the full resolution of the SeaWiFS sensor for a period of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Component approach for real-time and embedded'.

assistant: **Concept**

One general trend in software for real-time and embedded systems is towards complexity. This is due to the increased functionality these systems are required to support as well as to the fact that they are now often supposed to be part of a more general system and well integrated in it The software architectures currently used to design those systems were primarily meant to take into account performance issues and are not enough structured to support this increase in complexity.The challenge is thus to move from a performance-centric approach to a complexity-centric approach, while not loosing in that move the adequate support for performance and time management. Traditional software had also to face this increase in complexity and had developed new paradigms to take it into account. A very promising one is the component/container model. However current models (e.g., Sun's EJB, OMG's CCM -CORBA Component Model) were primarily dedicated to information systems and the services they propose (e.g., persistence) are not well suited for real-time and embedded systems.CORBA has moved towards real-time and embedded areas (cf. most of the recent adopted specifications); with the very recently adopted Lightweight CCM, CCM has started a move in the same direction by defining a minimum profile upon which it is now possible to build a model dedicated to real-time and embedded. The purpose of this project is to study a framework based on this model (CCM for real-time and embedded), to realise a reference implementation of it, to test it on two different application cases (one based on RT-CORBA, the second on OSEK-VDX RTOS) and to push the results at OMG for standardisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Science festival Researchers` Night in Slovakia 2013', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In 2012, we have successfully implemented science festival Researchers` Night for 6th time in Slovakia. During the first 5 years we have been presenting science in shopping malls where people were just caught by the latest research outcomes and successes of Slovak science. These years of hard work and increasing public interest in science showed us that Slovak society is prepared for the event dedicated only to science and its promotion. That is why, we moved main evening program of RN2012 to the Old Market Hall situated in Bratislava City Centre. It represents attractive venue opened only for a special occasions. Thanks to interactive presentations of latest scientific work and research outcomes of top Slovak researchers, we successfully created kind of festival atmosphere in the empty market hall.As proved by statistics, the RN2012 was the most successful. We have recognized increasing public interest in science and augmented awareness of all relevant stakeholders in Slovak education and R&D system. Municipality of Bratislava, Ministry of education and dozens of important sponsors have already promised us significant support for the next year event.The concept of RN2013 aims to expand the event through the Bratislava City Centre and upgrade it for all day long open air festival of Science.The main program will be held in Old Market Hall with various science installation and stands spread through the City Centre. People will have an opportunity to spend all day and night visiting different boots, testing scientific applications, getting in touch with the latest research outcomes and speaking to researchers. Thanks to the direct exchanges and discussions with the researchers people can discover their ""human face"". During the event and awareness campaign we will focus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Skeletal Muscle Inflammation: ambivalent roles in Exercise and Diabetes' (SMILED).

assistant: **Innovation**

In Europe, 52 million people are living with diabetes, with more than 90% of them having type 2 diabetes (T2D), a multifactorial disease associated with obesity and sedentary lifestyle. It leads to severe complications such as cardiovascular events and constitutes an unmanageable economic burden. Skeletal muscle inflammation is emerging as a potential contributor to T2D. Inflammation occurs during exercise and repair and is a hallmark of myopathies, suggesting that it plays crucial roles in skeletal muscle homeostasis. Despite the fact that exercise is associated with inflammation, physical activity has beneficial effects on T2D, which highlights the ambivalent role of muscle inflammation in controlling glucose homeostasis.Epigenetic processes are potential molecular links between diseases and environmental factors such as diet and exercise. Abnormal promoter methylation of inflammatory genes was recently suggested in adipose tissue during obesity, but little is currently known about epigenetic regulations in muscle during exercise and diabetes. Surprisingly, it is unknown whether there is any parallel between local inflammation of muscle and T2D and no therapeutic strategies currently target skeletal muscle for T2D treatment.The overall aim of this proposal is to determine the interaction between inflammation and the metabolic response to exercise and T2D to define potent interventional strategies that can improve insulin sensitivity. It will identify what type of inflammatory response induces the greatest metabolic effect on signal transduction and expression of genes through profiling DNA methylation, chromatin structure and small RNAs. It will use primary cell cultures from human biopsies to (1) obtain proof of principle that the beneficial effect of exercise on met
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dementia in Ankara and the Nature of Surroundings: The effects of everyday home and family environments on the health, well-being and identity of aging women' under Horizon Europe.

assistant: **Concept**

The COVID-19 pandemic continues to have a globally disproportionate impact on the well-being of people living with dementia  particularly those who are community-dwelling  who have seen reduced access to healthcare and increased risk of loneliness, isolation, and depression. Consequently, the 'home' has become a vital space of care that remains lesser-researched in dementia studies. This can be richly explored in the country of Trkiye, which borders the West, East, and Global South, and has a distinctly blended modern and collectivistic outlook regarding familial ties and gender roles. Focusing on Trkiyes capital city, Ankara, this project will explore the physical (natural, built, material, biophilic) and social (spousal, familial, communal) features of home environments, examining the relations between dementia, place-based experiences, daily living, and well-being. Inspired by integrated theories on relational and in-the-moment well-being, this project adopts a mixed methods case study design and asks the overarching research question: ""How do everyday interactions with both physical and social features of home environments promote or hinder the health, well-being and identity of older women living with dementia?"". This timely holistic project seeks to develop new scientific knowledge about the complex relations between, and intersectionality of, dementia, gender, landscapes, socio-economic status, familial dynamics, and daily living in the context of Trkiye. The research has strong interdisciplinary links across architecture, human geography, anthropology and gerontology, with exchange of knowledge between the candidate and host, Bilkent University's Interior Architecture and Environmental Design department. The findings coincide with UN and EU research plans, wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'X-by-Construction Design framework for Engineering Autonomous & Distributed Real-time Embedded Software Systems' (XANDAR).

assistant: **Concept**

The next generation of networked embedded systems (ES) necessitates rapid prototyping and high performance while maintaining key qualities like trustworthiness and safety. However, deployment of safety-critical ES suffers from complex software (SW) toolchains and engineering processes. Moreover, the current trend in autonomous systems relying on Machine Learning (ML) and AI applications in combination with fail-operational requirements renders the Verification and Validation (V&V) of these new systems a challenging endeavor. Prime examples are autonomous driving cars that are prone to various safety/security vulnerabilities. The XANDAR project is built to exactly match the goals defined within the ICT-50 Software Technologies.XANDAR will deliver a mature SW toolchain (from requirements capture down to the actual code integration on target including V&V) fulfilling the needs of the industry for rapid prototyping of interoperable and autonomous ES. Starting from a model-based system architecture, XANDAR will leverage novel automatic model synthesis and software parallelization techniques to achieve specific non-functional requirements setting the foundation for a novel real-time, safety-, and security-by-Construction (X-by-Construction) paradigm. For the first time, XbC-guided code generation for non-deterministic ML/AI applications will be combined with novel runtime monitors to ensure fail-operation in the presence of runtime faults and security exploitations. The project provides a consortium covering the full spectrum of ES and software engineering. XANDAR will be validated by an automotive OEM (BMW) and the German Aerospace Center (DLR). Leading European SMEs and enterprises such as Vector, AVN, and fentISS as well as successful academic partners will contribute thei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'History and Theology' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

'History and Theology: the creation of disinterested scholarship from dogmatic stalemate (ca. 1525-1675)' will deal with the question of how and why the seeds of religious tolerance came to be sown in an age of confessional polemic. This project will explore the idea that an unexpected consequence of religious polemic was the growth of disinterested scholarship, which, in turn, led to increased tolerance of religious differences. Indeed, once the strict rules and staunchly held positions of the rival confessional antagonists became known and established, scholars were able to pursue their research relatively freely within this framework and even across confessional boundaries. It became possible to describe change and diversity as historical facts rather than as simply polemical weapons in a battle of the books. In turn, this paved the way for the religious tolerance championed by several influential Church histories of the Enlightenment. The project will focus on two cultural zones: England and the Italian peninsula, in order to conduct a comparative study of a carefully selected number of key scholars from rival confessions and scholarly traditions. By means of a carefully calibrated dissemination strategy, this project is intended to have a wider impact on Europe’s troubled multi-faith society of the early twenty-first century by providing a fresh, new historical narrative which adds intellectual foundations to the moral desirability for mutual recognition and appreciation of diversity in religious debate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Pioneering physics-based design of two-phase flow in energy materials via wettability control', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

We are at a pivotal time in climate action. To fight climate change, we need to accelerate scale-up of clean energy technologies, like fuel cells, electrolyzers, and batteries, which underpin our energy transition. A major bottleneck in accelerating rational design of next-generation devices is the non-optimal, heterogenous, and often stochastic nature of porous materials within these devices. A vital design parameter of porous materials is pore-scale wettability, which can fundamentally alter transport of species, and thereby dictate device performance. However, we do not yet know the ideal wettability configuration to design our devices around due to fundamental gaps in our understanding of mixed wettability.In this project, I plan to synergistically combine three fields – physics, energy engineering, and automation – to provide a fundamental blueprint to design two-phase flow in next-generation energy materials. First, I will create a microfluidic platform to conduct high-throughput experiments and statistically analyse the effect of a wide range of wettability combinations on flow patterns. State-of-the-art wettability models will be advanced and validated using experiments and create a “mixed-wet phase diagram”. I will then computationally explore the established phase diagram to create designer porous materials with directed transport properties for energy application. Then, superior computational designs will be tested experimentally to cross-validate model capabilities and propose porous media for energy applications (with a focus on water transport in fuel cells).The multi-disciplinary physics-informed design strategy employed in the study is expected to benefit diverse clean energy technologies, with potential applications in microfluidic disease diagnosis and