RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Nanoparticles for Fluorescence-Enhanced Imaging and Therapy of Breast Cancer'.

assistant: **Concept**

Breast cancer (BC) represents a leading cause of cancer-related death in women worldwide, in large part due to ineffective detection and treatment. Nanotechnology offers new promise in mitigating BC mortality, by combining therapy with early diagnosis in “theranostic” nanoparticles (NPs). Here, a multidisciplinary approach is proposed to develop and evaluate novel theranostic NPs, which for the first time combine near infrared (NIR) metal-enhanced fluorescence (MEF) imaging with multimodal cancer treatment. MEF is a promising strategy for dramatically improving the low fluorescent signals of available NIR dyes, but limited MEF platforms for in vivo applications have been developed. Here, elongated gold (Au) NPs (nanobipyramids) with two sharp tips and tunable sizes/optical properties are expected to provide distinct advantages, including large fluorescence enhancement and increased tumour accumulation, thus enabling real-time in vivo imaging with high sensitivity and spatial resolution. Furthermore, BC photothermal therapy by the Au core will be combined with a chemotherapeutic drug-carrier surface coating, bearing pH-responsive lids to allow controlled drug and Zn ion release at the tumour site. Coordinated use of these modalities is expected to minimize systemic side effects, improve therapeutic efficacy and be useful in treating drug resistant tumours. Several complementary techniques, including computational modelling, 3D in vitro cell cultures, in vivo testing and advanced 3D imaging will be combined to characterize NP biodistribution, biocompatibility and passive vs. active tumour targeting. These will provide vital insights for the – still challenging – clinical translation of NPs in general, paving the way toward personalized nanomedicine. The proposed research/
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Innovative Swept Source for next generation OCT devices', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

According to the World Health Organization, 50% of all cases of blindness in Europe are preventable and 80% of all vision impairment is considered avoidable. However, early diagnostic requires comprehensive and accurate diagnosis tools. While OCT has emerged over the past two decades as the undisputed gold standard for accurate, high resolution local characterization of ophthalmic tissues, its limitation to provide wide field-of-views (FOV) over the entire eye structures has been vastly acknowledge as a key bottleneck to improve early diagnosis of eye conditions – in particular retinal vascular diseases (e.g. diabetic retinopathy).OCTLIGHT has developed a disruptive laser source – the heart of the OCT system – enabling a step improvement over competing alternatives in the market, providing the cornerstone towards the next generation of 3-dimensional, wide-field and high-resolution imaging of the eye. Besides its superior performance compared to current competitive technology, OCTL’s swept source delivers these advantages at a competitive price, providing an unmatched value proposition– not only in ophthalmic applications but also in other fields using OCT (e.g. cardiology, dermatology, etc.).Resonating with the fast expansion of the OCT market - expected to reach $1.8Bn by 2024 and growing at a double-digit rate – there is thus a very significant business opportunity for OCTLIGHT to gain a foothold as the lead (sub-)supplier of top tier OCT components. Hereto, the successful implementation of the present innovation project will represent a significant business opportunity for OCTLIGHT, with significant revenue/profit and job creation to be untapped in the first 5 years of commercialization. In addition, the present project is considered as a vital cornerstone to fuel OC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Psoriatic Arthrtis and Coronary Artery Disease'.

assistant: **Concept**

Background:Psoriatic arthritis is a multi-system auto-immune disease that affects approximately 0.15% of European populations. It can result in lost productivity and a decreased quality of life. The skin disease psoriasis is associated with cardiovascular disease. This is also true for rheumatoid arthritis. Initial data suggest an association between psoriatic arthritis and heart disease, but no population based studies exist. We propose a multi-disciplinary study combining advanced information technology and a collaboration between experts in cardiology and rheumatology. The proposed study is population based and addresses an important clinical question.Objective:To confirm and quantify the association between psoriatic arthritis and cardiovascular disease in the general population.Methods:Detailed population level data are available from the Icelandic Heart Association’s registry of every case of myocardial infarction occurring in the Icelandic population since 1981. We have previously compiled a list of all known cases of psoriatic arthritis in Iceland and propose linking this list to the heart disease registry. We will use statistical techniques including longitudinal data analysis to assess the risk of developing heart disease and cancer. To address confounding we will use two complimentary methods to compare the cardiovascular risk factor profiles of psoriatic arthritis patients to the general population.Benefits:The proposed project will improve the understanding of health risks associated with psoriatic arthritis. These risks can be taken into account when caring for these patients. Specifically, lifestyle modification and targeted screening can improve the survival and quality of life of cardiovascular patients.In addition to the scientific goals, this project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Implementation of joint bottom-up European Programmes in chemistry' in the context of a Sixth Framework call.

assistant: **Objectives**

ERA-CHEMISTRY aims at establishing a European Research Area in basic and applied chemistry (including transdisciplinary research) without national, formal and research subject boundaries by- Setting up a common information system on reviewing and funding of chemical research (including neighbouring disciplines) in all European countries- Providing jointly agreed processing and evaluation schemes for transnational proposals- Setting up electronic infrastructure facilities for transnational communication and for submitting and reviewing transnational proposals- Ascertaining innovative research fields particularly suitable for transnational research efforts Encouraging chemists across Europe to combine their complementary expertises in joint transnational projects- Incorporating research councils from new EU countries into the network by elaborating application and funding concepts with variable velocities of integration- Adjusting suitable ERA-Chemistry activities with those of neighbouring ERA-NETs- Developing and implementing sustainable joint European research programmes in chemistry in all degrees of complexity, including joint management- Increasing the competitiveness of chemical researchers in Europe by developing and implementing a truly integrated European research conference scheme- Launching transnational thematic calls with fixed budgets and deadlines- Launching transnational open calls in all fields of chemical research- Providing a framework for jointly agreed earmarked/common financing of chemistry-based transnational research projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Applications and Fundamentals of Microresonator Frequency Combs' (MICROCOMB) targeting Horizon 2020.

assistant: **Abstract**

The proposed network will establish and support cross-sectorial training  and research programme bringing together leading European academic and industrial centers working in the area of optical frequency combs in microresonators (microcombs). The programme will allow to combine and share some of the world leading experience and expertise in the  microcombs and train a new generation of scientists in this actively developing area bordering physics and photonic engineering and having pronounced  applied and fundamental dimensions. The frequency comb research itself is the Nobel prize winning area (T. Hänsch and J. Hall, 2005), while the microcombs can qualify as an emerging disruptive technology. Europe still lacks a structured and comprehensive training programme in this area, which is proposed by our consortium, while facing a growing competiton with its global rivals. This programme will have a lasting impact increasing European innovation capacity through expanding knowledge base, new IP, trained personnel, better equipped laboratories and future collaborations leading to product development. Our project addresses  research and technology problems with interdisciplinary importance from the areas of precision frequency metrology, ultrafast data processing, optical to RF signal conversion, astronomical measurements and soliton physics. Early stage researchers involved into the proposed network will receive broad and well balanced training in device characterisation and fabrication, experimental techniques and theory and modeling in best academic, research center and industrial environments. A programme of secondments and network wide events will ensure highest levels of cross-country and academia-industry mobility for our researchers. Soft-skills training events organi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'CERAMIC AND POLYMERIC MEMBRANE FOR WATER PURIFICATION OF HEAVY METAL AND HAZARDOUS ORGANIC COMPOUND'.

assistant: **Innovation**

The main objective of the CERAMPOL project is to achieve a new generation of smart and low-fouling nanostructured membranes based on ceramic and polymeric materials with enhanced affinity to heavy metals and drugs. CERAMPOL will contribute in solving issues related to waste water in metallurgic and pharmaceutical industries/hospital respectively. Moreover, by reducing the concentration of highly toxic contaminants in the water supplies, lakes, rivers, and streams, the new filtration technology developed in the CERAMPOL project will mitigate the risk to humans’ health and the environment such as bioaccumulation of heavy metals, the emergence of multidrug resistance organisms, chronic toxicity, and metal-related diseases.The new filters will be prepared by innovative processes such as electrospinning, sol-gel, coating processes for obtaining multi-layered membranes possessing several key properties such as: antifouling; self-cleaning; selective filtration of antibiotics and heavy metals. Specifically, the multi-layered membranes will composed of three functional parts CERAMPOL functional parts: an anti-fouling pre-filter based on polymeric nanofibers, a cleaning system based on piezoelectric materials, and a highly selective nanostructured ceramic membrane. The new filters will be scaled up at semi industrial level for in-situ water treatments in foundry, pharmaceutical and hospital effluents. The benefits of such technology will be fully characterized in terms of water filtration efficiency and economic and environmental impacts. Complete technological and economical viability assessments of the CERAMPOL technology will be carried out by the industrial partners. Environmental impact caused by the new filtration technology will be fully assessed in order to highlight bene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Synthesis of natural product derived libraries employing enantioselective allylation on the polymeric support as key step' under Sixth Framework.

assistant: **Concept**

This proposal falls into the area of construction of diversity-oriented natural product-like libraries for chemical biology and drug discovery purposes. The synthesis of such libraries requires the availability of efficient and practical methods, including asymmetric transformations with high degree of stereoselectivity, for the multistep solid-phase synthesis of frameworks of biologically promising natural products. The objectives are:1) Solid-phase synthesis of 5- and 6-membered ring lactones (compounds c losely related to some biologically active natural products),2) solid-phase synthesis of a Cytostatin-derived compound library. Cytostatin is a natural product isolated from a Streptomyces strain that inhibits the serine/threonine phosphatase 2A at submicr omolar concentration,3) biological evaluation of the compound libraries in biochemical screens (in vitro inhibition assays) by me in close collaboration with specialised scientists in the field.Targets 1 and 2 will be achieved by means of an enantioselecti ve allylation or crotylation reaction of chiral polymer-supported aldehydes as the key step (which has no precedents to the date, only previous studies in Waldmann group but still unpublished), followed by a lactonization process. This presumably will lead to a library of 5- and 6-membered ring lactones with a side chain in the ring. The points of generation of molecular diversity will be: modification in the size and variation in the substitution pattern of the lactone ring. Concerning the side chain, it w ill be modified mainly by using the alkene reactivity.The main aim is to increase the knowledge and interest of the scientific community in the use of asymmetric strategies in solid-phase synthesis and drug discovery. In addition, I expect to acquire new s kil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'STUDY OF MULTINUCLEAR COPPER AND ZINC COMPLEXES RELEVANT TO BIOLOGICAL ELECTRON TRANSFER PROCESSES AND SUBSTRATE BINDING'.

assistant: **Innovation**

Research objectives and content we plan to design novel oligopyridine ligands for the self assembly of (supra-)molecular structures as models for oligometal enzymes. Rigid, linear polytopic ligands containing bidentate chelating sites will be used to self-assemble into square matrix arrays of metal centers with ions of tetrahedral coordination geometry, Zn(II) and Cu(I). By varying the number of coordination sites on the ligands, different sizes and shapes of metal arrays are envisioned. Additional ligands could be introduced by tuning solvation and anion interactions. This new approach to model the active sites of polynuclear metallo enzymes has the potential to yield large electron reservoirs to serve as relays in multi-electronic reduction processes (Cu) and provide complexes with the enhanced reactivity and selectivity of multi- metal hydrolytic enzymes (Zn). Training content (objective, benefit and expected impact) Through this project, the applicant will learn new synthetic methods of the preparation of self-assembly systems, as well as state-of-the-art spectroscopic techniques needed for sophisticated polyelectronic systems. This work is anticipated to result in biomimetic transformations which are of high interest in the fields of pharmacological and environmental chemistry. Links with industry / industrial relevance (22) Complexes might be used to investigate oxygenation reactions which are relevant to the development of practical catalysts for the mild, selective oxidation of organics. This project will be carried out on a non-financial basis, with potential interest of Rhtne-Poulenc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New female selective attractants for medfly' to be submitted under Fourth Framework.

assistant: **Abstract**

The Mediterranean fruit fly Ceratitis capitata is a major pest of the fresh frui t industry and is considered as a key agricultural pest in many parts of the wor ld. It attacks most citrus varieties, deciduous and subtropical fruits as well a s some vegetables. All the Mediterranean Basin countries, growing medfly host pl ants, suffer of its damages. Certain countries free of the medfly (U.S., most fa r-eastern countries, parts of Australia, some European countries), which are act ual/potential target markets for import of fresh fruits and vegetables, activate strict quarantine regulations against it. The most efficient currently used con trol system against the medfly is spraying a poison-bait mixture. Traps containi ng the powerful male attractant trimedlure are being used to monitor the medfly populations. Two additional environmentfriendly (EF) control systems are being s tudied and partly used - the mass 'lure and kill' trapping and the Sterile-insec ttechnique (SIT). In both systems female food lures are used as baits for traps. The bait presently used in control systems against the medfly is a liquid prote in hydrolysate intended to attract mainly females. Since the discovery of mcphai l (1939) on the attractiveness of such materials no breakthrough was reported. T he attractiveness of some commercial baits is no higher than that of some common ly used manures and fertilizers. New, more efficient baits are needed for contro lling the medfly. No female attractant(s) of similar power to trimedlure (for ma les) is known. Since the females are the fruit damaging population is the genera l goal of the project the development of female specific attractant(s). The prop osed development of an improved bait is based on the attraction of medfly to amm onia. This general go
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Synergistic growth factor microenvironments for veterinary bone regeneration.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

We propose a system that allows a safer delivery of recombinant human bone morphogenetic protein-2 (rhBMP2) for bone tissue engineering and have planned a veterinary trial in relevant conditions. We have teamed up with a team of veterinary surgeons and several industry and clinical partners for the appraisal of the proposal from a translational standpoint. rhBMP2 is a powerful growth factor (GF) essential in tissue morphogenesis and used to promote bone growth in clinical applications. Current clinical delivery has encountered serious complications associated with the high doses used. We have developed a system that allows the effective presentation of GFs in combination with the integrin binding domain of fibronectin (FN), promoting simultaneous and co-localised signalling between GF receptors and integrins. We have shown the ability of Poly(ethyl acrylate) PEA to organize FN and sequester rhBMP2 in synergy with the integrin binding region to direct stem cell differentiation. This technology enhances bone regeneration and vascularisation with lower rhBMP-2 doses. With this understanding we have engineered systems to regenerate a bone critical size defect in a murine model. Results were comparable to the higher doses used in the clinic, which makes the systems safe, effective and more competitive than current commercial products. The pathway to human applications requires strong financial commitments. We will explore the veterinary application of our technology and also, because of the conditions treated, as a demonstration towards application in humans. Overall, we will develop a safe and versatile bone system for clinical use in joint arthodesis and non- union bone defects, and we will set a route towards commercialization.