RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Aerodynamic and aeroacoustic modeling of closely operating propellers for DIStributed PROPulsion' to be submitted under Horizon 2020.

assistant: **Abstract**

DISPROP aims at improving the current aerodynamic and aeroacoustic analysis and design capabilities for large aircraft operating with distributed propulsion (DP) and propeller arrays. This will be done by generating a high-quality, industry-relevant experimental database using 2D and 2.5D wing sections equipped with propeller arrays. Using this database, the capability of existing CFD and CAA codes will be updated in order to better predict the relevant aerodynamic and aeroacoustic interaction phenomena occurring between the wing and the propellers slipstream. Parametric studies will be conducted to identify most promising configurations.This 30-months 2,7M valued project will consist of four phases. After a preparatory phase, where relevant geometries will be selected based on their high potential for DP, two to three wing geometries will be highly parametrized in Phase 1 and investigated by both CFD and medium-scale wind tunnel tests (WTT). Then, in Phase 2, the most promising configuration will be wind-tunnel tested in large scale at DNW NWB to generate aerodynamic and aeroacoustic experimental database that will be used to validate CFD and CAA simulations. In a subsequent exploitation phase, the combined numerical and experimental database will be extrapolated to full-scale 3D geometries based on the advanced Power Balance Method.The analysis and design tools matured and validated within DISPROP will enable the development of new aircraft configurations with DP and closely integrated propellers. Operating with a drastic increase in overall efficiency compared to conventional aircraft, such configurations contribute to the CS2 objective of reduced CO2 emissions.The DISPROP consortium is composed of internationally recognized experts in CFD and CAA modeling, academic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nitrogen-Radical-Based Radical Strain-Release Strategies for the Divergent Assembly of Polyfunctionalized 3D-Building Blocks' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Nitrogen-containing compounds underpin every aspect of our life: they form the structural basis of almost all drugs, agrochemicals and materials. The invention of methods to form C–N bonds is of strategic importance to discover and evolve molecules with direct implications on our lives. Central to this quest is designing synthetic strategies able to explore novel areas of chemical space. As the pharmaceutical sector is now aware of the greater clinical success of molecules with 3D architectures, developing methods able to assemble 3D-shaped and saturated building blocks is a topic of continuous scientific endeavour.  The small and strained bicyclo[1.1.1]pentyl motif has been identified as a valuable bioisoter to replace flat (2D) aromatics and improve the potency of lead molecules. However, difficulties in preparing and modifying this structural element have severely limited its use in medicinal chemistry. There is an urgent need to develop novel methods that can effectively manipulate and introduce this motif into organic compounds. This project seeks to substantially expand the fields of photocatalysis and nitrogen-radicals by introducing the concept of “photoredox strain-release”: a novel reactivity that explores the ability of nitrogen-radicals to react with strained hydrocarbons (eg propellane) and enable a unique preparation of polyfunctionalized bicyclo[1.1.1]pentylamines. This research capitalizes on recent developments of the host group that has disclosed 2 novel ways to effectively generate nitrogen radicals. This reactivity will be integrated with other reaction platform allowing the divergent 1-step construction of many important nitrogenated 3D-building blocks that cannot be prepared by any other method. The development of such an innovative and ambitious p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'ERA Mobility and Researchers Career Days in Greece: A contribution to decrease brain drain' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The project is led by the Centre for Research and Technology Hellas (CERTH) with 4 partners from the Greek EURAXESS Network and academic and research organizations.  The objectives of the project, addressing the call SwafS-20-2016: ERA Mobility and Career Day will be pursued over a 24 months period.  Main objective of the project is to organize ERA Mobility and Career Days in Central Macedonia, Epirus and Thrace (North Greece) and in the region of Attica (South Greece) by the Greek EURAXESS Services Centers with the support of the national BHO.  As a first step, guidance and practical support to students and young, experienced researchers will be provided on how they can enhance their geographical and inter-sectoral mobility, as well as their career development during the Advisory and Training of the Candidates – Preparatory Workshops (Laboratories) and the Individual Advisory Support aligning, thus, with the Horizon 2020 objective.  The ERA Mobility and Career Days will have a highly interactive character enabling one to one meetings of researchers with employers or recruiters in order to acquire useful information on the process for hiring researchers in Research Organizations and Industry. The overall output will consist of the production of a Best Practice Manual for the organizing of “Career Days” event.The impacts are linked to increasing the visibility European job and funding opportunities mainly published on the EURAXESS Jobs portal and personalized assistance tools such as EURAXESS addressing the open labor market for researchers inside and outside Europe. An additional impact should be to attract young people to follow research careers with mobility, taking into account the brain drain situation and the high unemployment rate faced by Greece.


**Keywords:**
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Colloidal Inorganic Nanostructures for Radiotherapy and Chemotherapy' (ICARO).

assistant: **Concept**

Radio and chemotherapy are the major clinical treatments for cancer. However these treatments lack cell specificity and can have severe side effects against healthy cells, especially when used in combination. My goal is to develop a nanocrystal (NC) platform to merge radio and chemotherapy into a single entity that is more specific towards tumor cells. To achieve ICARO’s goal, three main objectives will be pursued. The first objective is to introduce post-synthesis reactions, namely cation exchange (CE) and intercalation (INT) reactions, as new protocols to replace or intercalate cations that are useful as radionuclides within the crystal lattice of water-soluble NCs. Our goal is to establish protocols for the preparation of radiolabelled-NCs that will be easily translated to the medical practice for radiotherapy. This requires CE/INT reactions that occur in aqueous media, possibly with NCs prefunctionalized with specific recognition molecules to achieve targeted radiotherapy. To minimize the radio exposure of the operator, CE/INT protocols will be carried out as the last step of NC preparation. The second objective of ICARO will be to explore in situ CE/INT reactions with NCs entrapped in a matrix that simulates the tumor mass. By first located NCs at the tumor and then let the CE/INT to occur, enhance therapeutic effect is expected. The third objective of ICARO will be to develop heterostructures to combine radio and chemotherapy. They will include at least one semiconductor NC on which to perform radiolabelling protocols and one portion made of a superparamagnetic (SP) NC for magnetically triggered drug release. With respect to magnetic hyperthermia, which exploits SP-NCs to produce bulk heat (>46°C) at the tumor, the local heat effect generated at the surface of SP-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of new sp3 C–H carboxylation strategies via interrupted Ni-catalyzed chain-walking catalysis' (CARBO-CHAIN).

assistant: **Concept**

While originally designed to control the topology of polymers, catalytic chain-walking reactions have recently offered new vistas for forging carbon-carbon bonds at previously unfunctionalized C(sp3)–H sites by formally translocating the metal catalyst throughout the alkyl side-chain of a substrate. In particular, nickel catalysis has positioned at the forefront of this emerging field due to its modular reactivity through one- or two-electron pathways. Nevertheless, the chain-walking process is poorly understood in mechanistic terms, being the nature of the active intermediates still subject of considerable speculation, and with Ni(I) or Ni(II) species arbitrarily proposed with no supporting experimental evidence.This project will tackle the challenge of isolating and characterizing discrete Ni(I) and Ni(II) intermediates to test their reactivity in chain-walking scenarios. Control at Ni disproportionation-comproportionation events, and the use of alkyl carbon fragments with appendant carbonyl chelating-motifs will materialize this goal by intramolecularly stabilizing the nickel complexes. The knowledge acquired will be utilized for a regiodivergent chelation-controlled carboxylation of Weinreb amides with CO2, delivering 1,4-dicarbonyl motifs with two orthogonal molecular handles. Lastly, the asymmetric variant of this transformation will strengthen future applications of this novel reactivity in de novo drug synthesis, late-stage functionalization approaches, and radiolabelling assays.


**Keywords:** Nickel catalysis,  Chain-walking,  C–H functionalization,  Carbon dioxide fixation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Amorphous carbon-boron-nitrogen coatings for high temperature applications in cutting tools', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives and content The aim of this project is the development of new materials based on the system carbon-boron-nitrogen for use as hard coatings in high temperature applications (up to 800 C). At present there is a great demand in the industry for coatings able to support severe working conditions in the high temperature range (as it occurs in high speed cuttings tools, punching and extrusion dies, moulds for both metal and glass, etc.), since this range is still not well covered by conventional materials (like TiN) Extremely hard and high wear resistance coatings can be synthesised in the C-B-N system for these applications, as the presence of boron and nitrogen in the carbon compounds is expected to increase the oxidation resistance at high temperature and the chemical inertness under aggressive environments. For this purpose. CBxNy compounds of variable composition will be deposited by reactive DC a RF sputtering, starting from C2B4C (and possibly BN) targets in a N2 atmosphere. The development of the deposition process and the study of the variables which control the final properties of the deposits, is one of the main aspects of the project. The composition, morphology and structural properties of the coatings will be measured by surface analytical techniques. In addition, the tribological characteristics of deposits will be also tested on flat substrates and on 3D parts working at high temperatures. Although the range of applications is wide we will concentrate on mechanical testing of two different types of tools: drills, and hobs, which are used in present cutting operations by the industrial partners. These tools represent two extreme working conditions: high and low cutting speeds, respectively. As a final goal apart from the good chemical stability of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Matter-wave gravitational wave interferometers' in the context of a Sixth Framework call.

assistant: **Objectives**

The goal of this research is to study a novel technique to detect and measure gravity waves: atom interferometry. Current methods employ laser interferometry (both LIGO and VIRGO are on-line and they are broad-band instruments) or the excitation of resonance s in acoustic detectors. They will reach in the mid-future their physical sensitivity limits; it is therefore crucial to timely start developing alternative techniques and working on new approaches.The mathematical treatment of matter-wave interferometers in a time-dependent gravity field has recently been a matter of debate and several papers have been published on the correct analytical framework. Beyond this important stage, which I am also interested in and consider the fundamental start of any related inquire activity, it will be necessary to walk all the steps needed to define viable interferometric configurations and especially to quantitatively assess their design sensitivity.This implies identifying the relevant noise sources and quantifying their effect. Such a plan will involve several disciplines, from gravity wave phenomenology to matter-wave optics, and will also require mastering a variety of practical issues, from the generation and transport of high luminosity atom beams to the thorough study, simulation and operation of such high-sensitivity instruments. This kind of activity is in line with my past experience on novel techniques for envisioned future gravitational wave antennas and for the study and control of currently running ground-based laser interferometers.I plan to conduct this research in close collaboration with both the INFN Laboratory and the Department of Physics in Florence, where many programs on gravitational wave astronomy are being advanced by an established group that is playing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project '"RNPnet"" - RNP structure, function and mechanism of action""'.

assistant: **Objectives**

RNA molecules are at the heart of life. It is now commonly admitted that nearly all the human genome is transcribed, and a wealth of new coding and non-coding RNAs have been discovered. Importantly, modern RNAs are never naked, but always exist in complex with proteins to form RNPs (Ribonucleoproteins). In the case of non-coding RNAs, these proteins are usually stably associated with the RNA and help to perform their function. In contrast, RNA binding proteins are usually transiently bound to coding RNAs, and control various aspects of their metabolism. For the next generation of scientists, a great challenge will be to understand the function and the mechanisms of action of the myriads of RNPs.The goal of this ITN (“RNPnet”) is first to bring together existing labs from different discipline, to join forces and tackle key questions in the field, and second, to produce highly-trained young researchers that will be sensitized to RNA and possess a multidisciplinary approach to research. The multiple expertises present in the fifteen labs of this network will be used in a highly cooperative and integrated manner. The research training will focus on studying RNPs involved in mRNA surveillance, splicing and editing. In addition, a total of fifteen meetings including two summer schools and several workshops are planed to strengthen education and interaction among participants of RNPnet.Finally, another important aspect of RNPnet is the presence of two industrial partners. Their aim is to use the enormous potential of RNA biology in therapeutic applications, either by modifying RNAs and using it as a drug, or by targeting specific RNA binding proteins with small molecules. We foresee that the presence of industrial partners will be highly beneficial for the students, and that,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Towards CMOS-compatible molecular electronics' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The project will investigate molecular junctions and will assess device platforms for compatibility with CMOS technology towards future applications of molecular electronics for memory technologies. In a first step we will therefore investigate metal-molecule-metal junctions utilizing metals compatible with CMOS technology such as Pt and Pd as more stable electrodes for molecular electronics. In particular, the mechanically controllable break junction technique and the liquid STM will be utilized to establish single-molecule junctions based on Pt and Pd. Molecular model systems will be studied to establish standards for molecular junctions similar to those already established for gold-based molecular electronics. This includes molecules with different anchor groups than the standard thiols to optimize the electronic coupling  of the molecule-metal interface and thus enhance the conductance of the molecular junction.In a second step, the project will assess and evaluate the feasibility of scalable devices of reduced dimensions using the above mentioned CMOS compatible electrode materials, with the ultimate goal of delivering supporting technologies for the fabrication of scalable, room-temperature-operating two-terminal molecular junctions.The above investigations will underpin the deployment of a range of robust two-terminal molecular-scale devices as well as support experimental demonstrations of principle and feasibility of molecular-scale functional devices. The successful completion of this project will be a first step towards CMOS-compatibility and thus integration of molecular-scale devices.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integrating China in the International Consortium for Personalised Medicine' (IC2PerMed), addressing dissemination and exploitation.

assistant: **Impact**

Personalised Medicine (PM) approaches, thanks to the latest technological advances notably in the fields of biomedical and digital technologies, prove their potential to improve healthcare and underpin more efficient and sustainable health systems. PM is at the top of the European Commission research agenda, with funding devoted to projects along the entire value chain. In China, PM is attracting massive interest, with the government capitalising on its expertise in biotechnology, computing hardware and the ability to put in place the infrastructures for supporting large bioinformatics projects. Turning PM into an opportunity for all citizens and patients requires the engagement of all stakeholders, in order to define common research and development approaches, standards, and priorities, and to scale up the collaboration at the International level. In order to respond to these challenges, the EU supports actions developed within the International Consortium for Personalised Medicine (ICPerMed). IC2PerMed project will provide key solutions for enabling the convergence under ICPerMed consortium of European and Chinese stakeholders towards a common approach of PM research, innovation, development and implementation involving policy makers and healthcare beneficiaries, by:- mapping policies, programmes, standards and initiatives related to PM in Europe in China for identifying the opportunities for research collaborations;- structuring its developments upon an ecosystem of European and Chinese experts, collaborating in Working Groups centred on ICPerMed Action plan priorities;- setting bridges with key organisms involved in the definition and implementation of PM and healthcare systems in both economic areas, both on benefits for coordinated approaches for research and on c