RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Uncovering the Mammalian Targeting Machinery for Tail Anchored Proteins' (2007-2013).

assistant: **Concept**

Activation of the BCL2 oncogene underlies a wide variety of malignant transformations. BCL2 must be present on the membranes of both the mitochondria and the endoplasmic reticulum (ER) to carry out its role in protecting cells from cell death (apoptosis). To enable its anchoring to intra cellular membranes, BCL2 has a C-terminal hydrophobic tail in a unique topology shared by members of a large family of Tail Anchored (TA) proteins. In mammals hundreds of such TA proteins exist that serve diverse and essential functions on every intracellular organelle. Despite the great importance of these proteins for cellular function, the pathway for enabling their anchoring to membranes has remained unknown for many years. We have recently discovered the protein machinery required for insertion of TA proteins into ER membranes in an effective and membrane specific manner in yeast. However, the mammalian pathway is not fully characterized. Moreover, the proteins required for insertion of TA proteins into mitochondrial membranes in both yeast and mammals are completely unknown. This proposal aims at uncovering and characterizing the machinery responsible for inserting BCL2 and other TA proteins into membranes in mammals. We will take two approaches – in the first, the homologous machinery to the GET complex in mammalian cells will be explored and its affect on BCL2 localization will be studied. In parallel, we will screen for components of the cellular machinery required for insertion of TA proteins into the mitochondria using high-throughput microscopy based silencing screens in mammalian cells. The discovery of the molecular machinery guiding the sub-cellular fate of the dual-localized BCL2 oncogene, can serve as a tool for better understanding BCL2 functions and for controlling it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LightCure - Light for double specificity and efficacy without burden' (LightCure).

assistant: **Concept**

Congenital hyperinsulinism (CHI) is a group of rare diseases of newborns and infants with functionally defective nonneoplastic beta-cells that cause hypoglycemia and severe morbidity through oversecretion of insulin. CHI is a major cause of hypoglycemic brain injury with intellectual disability, epilepsy and cerebral palsy. As no registered causal therapy exists, management of CHI aims at increasing blood glucose levels causing severe side effects in all patients while life-threatening frequent hypoglycaemias remain. Removal of hyperfunctioning beta cells by pancreatectomy leads to insulin dependent diabetes mellitus (IDDM) and maldigestion of food, changing one disease for another with severe secondary morbidity. Management of CHI is choosing between evils and symptomatic management is partially effective in only some sub-types. CHI also represents a major burden for families, because of disability but also as a result of continuous monitoring and correction of glucose levels for many years, requiring permanent alertness. Health problems and economic decline occur in most parents. A normal life is not feasible for families with babies with CHI. LightCure consortium partners have demonstrated the feasibility of selectively targeting beta cells using exendin 4 (EX) labelled with a photosensitizer (700DX) specifically binding to beta cells. This photosensitizer can be activated by light of a certain wavelength and will produce radical oxygen species leading to cell damage, a principle called targeted photodynamic therapy (tPDT). In this project we will build on existing cutting-edge technology exclusively available to the consortium partners and perform human proof of concept studies demonstrating safety and efficacy of tPDT with EX700DX. We will deliver the proof-of-conc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Scalable Multi-tasking Baseband for Mobile Communications' (Multi-Base) targeting Seventh Framework.

assistant: **Abstract**

In order to strengthen Europe's leading position in high-speed, end-to-end, mobile network systems technology, the Multi-Base consortium has identified three main areas where research will have a major impact on the advancement of state-of-the-art technology and the emergence of a sound competitive and innovative environment for the European communications and services industry:<br/>A)\tmulti-tasking radio<br/>B)\tscalable reconfigurable multi processor technology (MPSOC frameworks) and<br/>C)\talgorithm/architecture co-design for maximum energy efficiency.<br/><br/>The Multi-Base project objectives target the elimination of key technical and commercial barriers to ubiquitous broadband access by enabling efficient and sustainable disposition of operation and production factors as spectrum, power engineering cost and silicon process technology.<br/>Drawing on project research in these three areas, the Multi-Base consortium will demonstrate new handset baseband architectures that enable end-to-end interconnection of humans and devices, with ability to support tenfold scaling in the number of interoperating connectivity links at the same cost and power consumption as today's technology. For more information please see www.multibase-project.eu.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Public Transportation - Accessibility for All'.

assistant: **Objectives**

Pubtrans4all will develop a prototype vehicle-based boarding assistance system that can be built into new rail vehicles or retrofitted into existing rail vehicles to improve accessibility for all persons. Accessibility for rail vehicles is particularly problematic since rail vehicles have a long service life and so many currently inaccessible vehicles will remain in service well into the future. PubTrans4all will help make existing public transport systems more accessible, improving service for everyone.The PubTrans4all project’s objective is to develop a standard boarding assistance system that can be used on many different types of rolling stock and infrastructures. The boarding assistance system will not simply be a device, but rather include contributing elements that make it possible to effectively use the device to access rail vehicles. The prototype will be developed by a multi-disciplinary consortium including users, public transport operators, academic researchers and manufacturers.As part of the process of developing the prototype boarding assistance system, the project will survey state of the art accessibility devices and make recommendations for best practices in the use and operation of these existing devices. The project will include an extensive dissemination program designed to communicate study results widely, but also to help inform the general public and decision-makers about the importance and challenges in providing accessibility for all.The PubTrans4all project will be completed by a well balanced and geographically diverse consortium. Especially beneficial is the participation of several Eastern European partners – since accessibility is not sufficiently recognized as a problem in many of these countries.Accessibility for all is critical to creat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cardiomics: Use of -omics methods in large populations for identification of novel drug targets and clinical biomarkers for coronary heart disease' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

There is a large need for revitalization of the research on coronary heart disease (CHD) including: a) improved risk prediction and more adequate individually-tailored treatment; and b) new targets for drug development based on pathways previously unknown to be involved in CHD pathophysiology.The overall goal of this proposal is to improve prevention and treatment of CHD through better understanding of the biology underlying disease development, identification of new biomarkers for improved risk prediction, and discovery of novel targets for drug development.The specific aims are to:1) Establish and characterize causal genes in known CHD loci (gene regions) through: a) resequencing of known CHD loci; b) expression profiling in liver, arteries, myocardium and skeletal muscle; c) high-throughput protein profiling; and d) experimental follow-up in zebrafish (Danio rerio) models.2) Discover new proteins, metabolites and pathways involved in CHD pathophysiology using global proteomic and metabolomic profiling to provide new biomarkers and drug targets.We will integrate genomic, transcriptomic, metabolomic and proteomic data from five longitudinal, population-based cohort studies with detailed phenotyping and one study with tissue collections for expression studies. The cohort studies include 36,907 individuals; there are 3,093 prevalent CHD cases at baseline and the estimated number of incident (new) events in previously healthy by 2016 is 2,202. In addition, we work with zebrafish model systems to establish causal CHD genes and characterize their mechanisms of action.We have access to unique study materials, state-of-the art methods, and a strong track record of successful projects in this field. To our knowledge, there are no other groups combining -omics methods to elucid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European Global Transition Network on Eco-Innovation, Green Economy and Sustainable Development', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In the last two decades the world has experienced several crises. In light of these trends and to more effectively move towards sustainable development, several organisations and international actors have developed the concept of green economy as action-oriented approaches. Priority interventions are aimed at triggering technology adoption, and stimulate behavioural change. In fact, eco-innovation can be considered an enabler for a green economy to the same extent that the green economy can be understood as an enabler of sustainable development.Green.eu is designed to address these challenges, ranging the conceptualization of eco-innovation and the green economy, to the harmonization of the approaches needed to coherently assess performance, identify gaps (successes and failures) for the effective adoption of technologies that can create win-win results. In particular, the project is designed so as to improve (1) harmonization of definitions, (2) collection of relevant information on the performance of past and current efforts, and (3) coordination among stakeholders. Green.eu sees the main challenges in an improved understanding (and scientific assessment) of the concepts of green economy and eco-innovation, on the adaptation of policy agendas, the documentation of best practices and guidelines for knowledge transfer and transferability.The inter- and transdisciplinary green.eu network (including knowledge brokers, programme owners and global industry networks) is research based and aims to accelerate the transition towards a green economy significantly, with a European focus on co-development of knowledge. It aims to exploit win-win-opportunities and to improve the take up of R&D results. It includes the following work packages: Networking and co-ordination; Harmoniza
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Atmospheric surfactants Chemistry: imProving the predictions of cloUd Formation and Features (CHEMPUFF)' in the context of a Horizon 2020 call.

assistant: **Objectives**

Predicting the formation and properties of clouds the atmosphere still represents a major challenge today and a main source of uncertainties in weather forecasting, hydrology, and climate prediction. Some fundamental aspects of these processes are still poorly understood, such as the role of the surface-active compounds (or surfactants) and their chemistry in the droplet nuclei, predicted by theory 80 years ago but elusive to observations until recently. The objective of CHEMPUFF is to complete the understanding of these compounds and their role on cloud formation and climate by - simultaneously investigating aerosol surfactants and cloud events in different regions (mid-latitude continental, Coastal, and Boreal),- using the results, together with satellite data, to make the first evaluation of the impact of surfactants on the radiative forcing of clouds on climate, at regional scale, then at global scale in collaboration with global modelers,- using the field results to characterize the links between aerosol surfactants and the biosphere (microorganisms, vegetation), and investigate the existence of a vegetation/biosurfactant/cloud/climate feedback in collaboration with global modelers.The Researcher is a recent PhD graduate from India, who has already demonstrated exceptional talents and scientific excellence. He will be integrated to the Host group at CNRS, France, which has led the main advances on the topic of surfactants and clouds in recent years. In addition to learning unique knowledge and techniques from this group, CHEMPUFF will open the Researcher’s professional network to Europe, thus increase his career prospects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The Sensuous Appeal of the Holy. Sensory Agency of Sacred Art and Somatised Spiritual Experiences in Medieval Europe (12th-15th century)'.

assistant: **Concept**

Is sight the only sense actively involved in the perception of art? This is a crucial question for Western culture, dominated today by the hegemony of vision and the suppression of the other senses. By challenging the current ocularcentric paradigm, and assimilating notions on the cultural values of sensation, SenSArt provides the first examination of medieval sacred art from the unconventional lens of its sensory agency. Between the 12th and the 15th century Europe underwent an extraordinary artistic evolution and an impressive cultural revitalization, which sparked a reassessment of the role of sensory perception in systems of knowledge and spiritual enlightenment. SenSArt explores and compares different social environments in six selected regions, pursuing three groundbreaking objectives: A) it will analyse quantitatively and qualitatively the perceptual schemes that orientated the reception of sacred art, scrutinizing how art solicited its beholders through multiple sensory inputs; B) it will develop and investigate the new notion of sensory agency of art, establishing sacred art as a primary actor capable of exerting, through sensorial stimulation or deprivation, a social agency on its audience; C) it will provide an overall phenomenology of experiences on a European scale, by comparing the diverse patterns that different social groups lived on a local, regional and supranational scale. SenSArt will achieve its goals by developing a new combined approach at the crossroad of Art History, Philosophy and Text Studies; it will establish a multidisciplinary team of scholars to delve into a comparative set of materials, including normative texts on the senses and works of art. The project promises to bring about a paradigm shift in our understanding of Medieval Europe. I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Strategic integrated assessment of dynamic carbon emission reduction policies'.

assistant: **Innovation**

Problems to be solvedStrategies of the EU in international negotiations on carbon emission reductions will be analysed in this project. A decision support tool will be developed to help European policymakers to design the long-term EU climate policy. The decision support tool will be built in form of an integrated assessment model. A major innovation is intended to be achieved by applying the integrated assessment model in a dynamic-sequential game framework. Therein, the actual and complex nature of the negotiation process is specifically addressed by considering the incentives of each big player of the world economy. In addition to the modelling activity in the centre, the project also includes a literature review and intensive policy analyses. The project will address the following questions:(1) Which are likely scenarios beyond Kyoto in the long-term, in particular concerning the policies implemented by non-Annex B countries and non-EU countries?(2) Which is the best strategy of the EU with respect to the different scenarios for climate change negotiations in the next few decades?Scientific objectives and approachThe proposed project will be conducted through the implementation of several work packages. A literature review of theoretical and empirical models of international climate negotiations will be done first. The main task then is to develop the decision support tool and to demonstrate its usefulness for policy analysis. The decision support tool will be built in the form of an integrated assessment model (IAM). Given the multi-disciplinary nature of the climate change issue, the model has its foundation not only in economic theory, but also in climate-related science, such as meteorology and geophysics. The model will represent reality by simplifying to a lar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Studying the combined effect of microplastics, pesticides and global warming on the sea urchin: a multidisciplinary approach to protect marine ecosystems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Urgent actions are needed to recover marine ecosystems from damage caused by human activities. The global aim of App-Marie is to study the joint effects of microplastics (MPs) and the chemical chlorpyrifos (CPF), two of the main stressors in our oceans, in different scenarios of climate change, using embryos of the sea urchin (Paracentrotus lividus). This will be achieved by combining molecular and biochemical techniques together with bioassays that will allow to assess their impact at a molecular, individual and population levels. We also aim to develop a standard protocol for performing bioassays to simultaneously test several toxics/stressors and apps able to analyse multifactorial data obtained and to predict their impact at the different levels of organization. The project will be carried out by Dr Bertucci in a highly recognized institution, Spanish Institute of Oceanography (IEO), under the supervision of Dr Bellas. Additionally, two international companies with great experience in the fields of energy and petrochemistry (Shell) and plastics (AIMPLAS) will act as collaborators providing their guidance to ensure the deliverables of the project meet the requirements to be used by industries. Dr Bellas is an international leader in marine contamination and MP pollution, ensuring an outstanding training environment for the ER. On the other hand, the deep background in comparative endocrinology and molecular biology of the ER will ensure the two-way transfer of knowledge. While completing the project, the ER will acquire diverse state-of-the-art skills and interact with international industries, expanding his scientific and personal horizons to become an independent researcher. All resources arising from App-Marie (protocols, apps) will be used to create a research fr