RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Biofunctionalised Electroconducting Microfibres for the Treatment of Spinal Cord Injury' (Neurofibres) under Horizon 2020.

assistant: **Objectives**

Bio-electronic microsystems hold promise for repairing the damaged central nervous system (CNS). However, this potential has not been developed because their implantation inflicts additional neural injury, and ensuing inflammation and fibrosis compromise device functionality. In Neurofibres we want to achieve a breakthrough in “Neuroregenerative Bio-electronics”, developing dual-function devices that will serve as electroactive scaffolds for CNS regeneration and neural circuit activation. We engineered electroconducting microfibres (MFs) that add negligible tissue insult while promoting guided cell migration and axonal regeneration in rodents with spinal cord injury (SCI). The MFs also meet the challenge of probe miniaturisation and biofunctionalisation for ultrasensitive recording and stimulation of neural activity. An interdisciplinary consortium composed of neuroscientists, medical specialists, researchers in biomaterials, protein engineering, physics, and electrical and mechanical engineering, together with a company specialised in fabrication of microcables and microconnectors, will join efforts to design, develop, and test the MFs and complementary technology (microfibre functionalisation, assembling, and electronic interconnection), in order to produce a biologically safe and effective bio-electronic system for the treatment of SCI. This goal will be achieved through five specific objectives: 1) To improve the electrical conductivity, strength, and chemical stability of the microfibres.2) To develop electro-responsive engineered affibodies for microfibre functionalisation.3) To develop the technology for MF interconnection and assembling into implantable systems.4) To perform comprehensive investigation of the immunological, glial, neuronal, and connective tissue
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Alzheimer's disease and Zinc: the missing link ?' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Alzheimer's disease (AD) is one of the most serious diseases mankind is now facing as its social and economical impacts are increasing fastly. AD is very complex and the amyloid-β (Aβ) peptide as well as metallic ions (mainly copper and zinc) have been linked to its aetiology. While the deleterious impact of Cu is widely acknowledged, intervention of Zn is certain but still needs to be figured out.        The main objective of the present proposal, which is strongly anchored in the bio-inorganic chemistry field at interface with spectroscopy and biochemistry, is to design, synthesize and study new drug candidates (ligands L) capable of (i) targeting Cu(II) bound to Aβ within the synaptic cleft, where Zn is co-localized and ultimately to develop Zn-driven Cu(II) removal from Aβ and (ii) disrupting the aberrant Cu(II)-Aβ interactions involved in ROS production and Aβ aggregation, two deleterious events in AD. The drug candidates will thus have high Cu(II) over Zn selectively to preserve the crucial physiological role of Zn in the neurotransmission process. Zn is always underestimated (if not completely neglected) in current therapeutic approaches targeting Cu(II) despite the known interference of Zn with Cu(II) binding. To reach this objective, it is absolutely necessary to first understand the metal ions trafficking issues in presence of Aβ alone at a molecular level (i.e. without the drug candidates).This includes: (i) determination of Zn binding site to Aβ, impact on Aβ aggregation and cell toxicity, (ii) determination of the mutual influence of Zn and Cu to their coordination to Aβ, impact on Aβ aggregation, ROS production and cell toxicity.Methods used will span from organic synthesis to studies of neuronal model cells, with a major contribution of a wide panel of sp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'VPH-Cardiovascular Simulation and Experimentation for Personalised Medical Devices'.

assistant: **Innovation**

VPH-CaSE is focused on state-of-the-art developments in personalised cardiovascular support, underpinned by simulation and experimentation, building on the foundations of the Virtual Physiological Human (VPH) Initiative. The Individual Research Projects of 14 ESRs provide knowledge exchange across three research clusters (i) Cardiac tissue function and cardiac support(ii) Cardiovascular haemodynamics - pathology and intervention(iii) Image-based diagnosis and imaging quality assurance. The work will be directed by the needs of industrial and clinical Beneficiaries and Partners, providing a truly multi-disciplinary, multi-sectoral environment for the ESRs. This will combine the expertise of nine core Beneficiaries (5 academic, 4 industrial) and 10 Partners (5 clinical, 4 industrial, 1 academic) to provide scientific support, secondments and training. VPH-CaSE will foster the development of ESRs within a collaborative environment. The recruited researchers will find themselves in an enviable position to leverage the expertise of a strategic sector of the European medical devices/simulation industry and engage with the issues faced by clinical experts in the domain of cardiac medicine and cardiovascular support. Their postgraduate studies will be informed by a translational bias that delivers a competitive skill-set, equipping them to address the challenges presented by a career at the cutting edge of technological innovation in healthcare delivery. The inclusion of a technology translation SME within the consortium is designed to promote the delivery of novel, tangible research outputs, providing benefits to a breadth of European sectors (eg. biomedical, clinical, VPH). The ultimate vision is the production of VPH-capable scientists with experience of tight integration of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ultra low-power integrated optical sensor systems for networked environmental multichannel gas Sensing' under Horizon 2020.

assistant: **Concept**

Distributed and networked gas sensing is increasingly important for industrial, safety and environmental monitoring applications. Optical nondispersive infrared (NDIR) gas sensors offer the highest sensitivity, stability and specificity in the market, but for most applications, the existing sensors are too bulky and expensive. To enable the broad utilization of high-performance gas sensor networks, there is a critical need for small, low-power and networked gas sensor systems. In ULISSES, we will develop an integrated multi- channel optical gas sensor system-on-a-chip (SoC) and demonstrate its capability to detect three gases simultaneously. Furthermore, we will develop the networking technology required to bring these SoCs onto the Internet of Things (IoT). We will implement a new edge-computed self-calibration algorithm that leverages node-to-node communications to eliminate the main cost driver of low-cost gas sensor fabrication and maintenance (the calibration). Finally, ULISSES will deliver the wafer-scale mass production methods necessary to enable production volumes of millions of sensors per year, and thus provide an order of magnitude reduction of sensor module cost. By leveraging recent breakthroughs of the ULISSES partners on waveguide integrated 2D materials-based photodetectors, 1D nanowire mid-IR emitters, and mid-IR waveguide-based gas sensing using MEMS-tunable filters, we target a three-order-of-magnitude reduction in sensor power consumption, thus permitting maintenance-free battery powered operation for the first time. Between the participants, we cover the full range of competences required for the task. The market for low cost IoT gas sensors is in its infancy, but at a 7.3% compound annual growth rate (CAGR) it is lucrative enough for players with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Beyond submerged landscapes - defining  human response to postglacial sea-level rise and climate change' (SUBNORDICA).

assistant: **Concept**

The landscapes that extended for millions of square kilometres offshore of the world’s coastlines due to low sea-level during the last glaciation and were then drowned by sea-level rise, are known to preserve valuable archives of landscapes, palaeoclimatic change and stratified archaeological remains, with the potential to transform understanding of human history in this period of dramatic change. The absence of archaeological sites across much of this vast area prevents realisation of this potential. In SUBNORDICA we propose a systematic approach to develop new methods for recreating the submerged landscapes and human settlement of NW Europe and assess the impact of postglacial sea-level rise. We will address two questions: (1) What changes to the topography and environment of the submerged landscape were brought about by rising sea level and climate change? (2) How was the distribution of archaeological settlements and other traces of cultural activity impacted by this changing palaeolandscape, and can we recover them in sufficient detail to investigate human impact and human response? Combining information from 4 regions in the southern North Sea and the southern Baltic, we will use artificial intelligence to develop machine-learning routines to (a) integrate existing and newly acquired geophysical and geological data to map key areas of the changing landscape, and (b) combine this information with data from known underwater archaeological sites to identify new targets of archaeological potential for more detailed investigation. Investigating these targets will use high-resolution geophysical methods, sediment coring, archaeological excavation, and  geochronological, palaeoenvironmental, sedimentological and biological analyses of recovered deposits. We will reveal a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Crevice-free, high reliability bi-metallic surgical instruments manufactured from shape memory alloys'.

assistant: **Innovation**

Flexible medical instruments such as bone reamers are currently constructed from multiple parts in dissimilar materials, which have very different properties. The current method of linking these parts together is by mechanical coupling. Effective decontamination of such instruments is challenging but is critical to avoid cross infection between patients. The geometry of the instrument assembly (particularly bone reamers and similar tools used in joint implants) have crevices at the joints which are difficult and expensive to clean and fully sterilise. Welded instruments would eliminate this problem.Approximately 7000 cases of MRSA infections were reported in UK hospitals during 2007 and similar issues are prevalent across Europe. Such infections are of particular concern in post-surgery patients. The CleanTools project aims to develop technology which will reduce this issue by making surgical instruments easier to clean and disinfect. The crevice between stainless steel cutting heads and Shape Memory Alloy (SMA) flexible shafts currently makes decontamination challenging, time consuming and chemically intensive. Additionally there have been instances of cutting heads becoming detached from the flexible drive shaft during use, causing undue implications in theatre and potential long term impacts on patient quality of life.The desirable materials for these tools, such as SMAs and stainless steels, are challenging to weld and their properties are severely degraded when they are melted in conventional welding. CleanTools will provide a method for the manufacture of surgical instruments containing SMA materials though the use of rotary friction welding (RFW). RFW is a low heat input solid phase welding technology that will preserve the properties of the materials in question
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Biocatalytic flow reactors using extremophilic enzymes for a greener generation of aroma-compounds', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In tune with sustainable chemistry, the use of enzymes for synthetic purposes has indeed drawn much attention as it is seen as an eco-friendly process. From another perspective, flow reactor technology represents one of the new strategies introduced in last few years to advance sustainability of organic synthesis and shows many advantages compared with traditional batch methods, including improved heat and mass transfer, efficient mixing of substrates and shorter reactions time. AROMAs-FLOW innovative strategy involves a combination of flow reactor technology and biocatalysis to create an efficient and modern platform oriented to a green production of natural food compounds and capable of extraordinary versatility and reaction innovation. The excellent opportunities offered by using immobilized biocatalysts under flow reaction conditions, represent a research field of certain growth. Twenty target aroma-compounds, three types of enzymes as well as acetic acid bacteria as whole cells have been selected to focus the efforts on specific synthetic problems, and to efficiently implement knowledge transfer to practical applications. The innovative AROMAs-FLOW project will offer an attractive economical incentive to the food industry because of consumers’ preference for natural products, attributed to increasing health- and nutrition-conscious lifestyles, as well as an alternative to traditional agriculture at risk of possible shortages caused by local condition production (climate, pesticides etc.) and the responsible care of natural resources. Furthermore, alternative “natural” routes for flavours production in addition to plants extraction, are becoming increasingly appealing. In agreement with Europe 2020 strategy, the outcomes of my research will reduce the cost of energy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Next Generation Quasi-Adiabatic Propagator Path Integral (Quapi) Methods for Condensed Phase Quantum Dynamics' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The inevitable interaction of a quantum system with the environment leads to energy relaxation and decoherence which can result in novel phenomena and opportunities not present in isolated quantum systems. Of particular interest is the non-equilibrium relaxation dynamics subject to non-Markovian memory and at strong interaction with the environment. In such situations, novel and generally applicable computational methods are necessary for precise and reliable simulations of the many body dynamics of open quantum systems. For this purpose, a hierarchy of methodological developments is proposed within the framework of the quasi-adiabatic propagator path integral (Quapi) method that address (i) the generalization of the method to more complex environments, (ii) its numerical efficiency and scalability, and (iii) employ neural networks to leverage algorithm performance. Finally, (iv) a quantum algorithm-based strategy is pursued for accelerated numerical propagation algorithms on near-term quantum devices. The hierarchy of developments facilitates simulations of condensed phase quantum dynamics for more complex systems and ever complex environments to address highest relevance open questions and research objectives in the understanding of condensed phase quantum dynamics, specifically, if the interactions of a system with its environment potentially can affect the systems coherence, the underlying mechanisms leading to complex many body phenomena and the possibility of control of the system dynamics and its decoherence. Ultimately, the algorithm developments and novel conceptual approaches will yield a comprehensive numerical path integration software platform for condensed phase quantum dynamics simulations that has groundbreaking potential by facilitating extremely challe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Voltage measurement transformer based on active ceramic materials'.

assistant: **Objectives**

To improve the stability and efficiency of complex electrical transmission networks requires an everincreasing number of instrument transformers under higher system voltages. As the size, weight and cost of classical instrument voltage transformers increase dramatically with the voltage, there is a growing need for new kinds of measurement devices. The present project develops a new measurement alternative based on mechanical waves rather than magnetic fields. The transformer consists of a voltage sensor and associated electronic circuits. The sensor is based on active ceramic (piezoelectric) material that generate mechanical waves (emitter). These waves propagate through dielectric material and are converted to electrical signals in a receiver. The main areas covered by the project are:  Computer simulations of mechanical wave propagation and electrical field distribution in several voltage sensor structures.  Development of active ceramic materials adapted to the sensor requirements of the emitter and receiver.  Design and simulation of electronic circuits that process the electrical signals form the receiver.  Development of high voltage electrical components required for the whole measurement instrument.  Laboratory and field prototype tests. These tests will be carried out in existing facilities for testing previous generation of instrument transformers. The new kind of transformer is expected to reduce the volume (23%), weight (38%), isolating oil (100%) and manufacturing cost (31%) of the most advanced capacitor voltage transformer available in the market. In addition, it does not require maintenance and has lower environmental impact (no isolating oil and low electromagnetic emission).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Biological activities of dietary polyphenol metabolites present in human blood' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The aim is to determine the effects on transcriptional induction of genes in cells by polyphone metabolites and to compare this to induction by the original polyphone. This will combine the use of photochemical metabolites found in the blood in humans in vivo with the use of cultured cells and primary cells and techniques to measure gene expression.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'New Directions in Lightweight Cryptanalysis'.

assistant: **Concept**

Over the next five years, fifty billion new smart devices will be connected to the Internet of Things (IoT), creating a revolution in the way we interact with our environment. Such resource constrained devices will require lightweight cryptography to protect them and us from bad actors. Unfortunately, such schemes can be highly vulnerable: Two notable examples are the encryption schemes used in GSM cellular phones and in car remote controls - both broken by the PI. We claim that it is not sufficient to adjust the current design and analysis tools to the constrained environment. Instead, we must establish a new research methodology, aiming directly at the problems arising in the 'lightweight realm'. We plan to concentrate on four main directions. First, we will go 'a level up' to study the security of generic lightweight building blocks in order to find the minimal number of operations required to transition from insecure to secure designs. Second, when considering specific ciphers we will pursue practical low complexity attacks, which are more relevant to the lightweight realm than standard theoretical attacks. Third, we will pursue new directions toward establishing 'white-box cryptography' – a central challenge in IoT cryptography. Finally, we will explore further applications of discrete analysis to lightweight cryptography, trying to establish rigorous conditions under which the standard cryptanalytic techniques apply in order to avoid unnecessarily pessimistic security estimates.   For the near future, we hope that our research will make it possible to detect and fix weaknesses in existing lightweight ciphers before they can be exploited by the 'bad guys'. Looking forward farther, we hope to understand how to design new secure lightweight ciphers for the billions o