RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Data variability and parameter uncertainty in composite shaft structural vibration measurement and numerical model updating' to be submitted under Sixth Framework.

assistant: **Abstract**

The main goal of this project is to investigate the dynamic properties of fibre reinforced shaft. A combination of non-destructive experimental and numerical simulation methods will be employed. The test results will be used in two ways: to derive knowledge of mechanical properties of a structure and to update the non-deterministic Finite Element model according to values obtained from test. In the experimental part the variability of physical properties will be taken into account. Model updating will include uncertainties of its parameters by means of interval, stochastic and fuzzy methods.An optimisation technique for both test (sensor number and location) and numerical (model reduction) parts will be applied. Such a combination demands to take advantage of knowledge from several fields: free vibrations, composite materials, measurement methods (especially experimental modal analysis), variability in measurement data, uncertainties in model parameters, signal processing, finite element method modelling, model updating, optimisation, statistics. As a result of this project set of updated numerical models will be developed with an introduction of quality function assessing the influence of particular factors on model reliability related to overall workload demanded. Also a set of variable test data will be assessed with a criterion of its application in industrial cases like diagnostics, Structure Health Monitoring.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Towards European integration in seismic design and upgrading of building structures' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Foreseen ResultsSuccessful accomplishment of these tasks will, we believe, enhance the cohesion of the earthquake engineering community in an enlarged Europe and safeguard highly qualified human resources.Major earthquakes have occurred in a number of EU and CCE countries during the last 30 years, causing many casualties, substantial disturbance to the economy, and much physical damage to buildings, infrastructure and the environment. In all these countries a standard form of construction for houses, apartment blocks and public buildings, such as hospitals and administrative centers, is the reinforced concrete frame stiffened by infilled panels. It is not surprising, therefore, that research attention has recently been focused in this area, progress being made in the CCE countries on analytical approaches particularly concerning non-linear behavior, made possible by fast computers, and in experimental techniques making use of sophisticated facilities newly acquired by the EU partners of this proposal. The aim of the proposal is now to bring these two aspects of the problem together in one coordinated programme. We believe it to be a particularly appropriate activity, since research on the behavior of infilled frames in earthquakes requires the development of skills and knowledge across a broad spectrum of science and engineering, including such fields as electronic instrumentation, control engineering, signal processing, non-linear material behavior, software engineering and finite element methods. It is therefore perfectly in line with the stabilization of the RTD potential" aspect of the Inco-Copernicus programme.Eurocode 8 for construction in seismic zones, potentially pan-European in its applicability, has already prompted research on infilled frames, which has serv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'IMPACTS AND RISKS FROM ANTHROPOGENIC DISTURBANCES ON SOILS, CARBON DYNAMICS AND VEGETATION IN PODZOLIC ECOSYSTEMS' in the context of a Sixth Framework call.

assistant: **Objectives**

Boreal forests and podzolic soils supporting forest vegetation are of utmost importance in the global carbon cycle. The role of Russian forests as a sink of carbon is in fact acknowledged, but soils have even a higher capacity to store carbon and the ill uviation of organic matter in podzolic soils could enhance this phenomenon. Soil Organic Matter (SOM) that accumulates in the spodic horizons is protected from mineralisation due to the lower microbial activity and strong interactions with the inorganic phases. Anthropogenic disturbances may deeply interfere in the podzolic ecosystem functionality and this sink of C may turn into a source. The objectives are to evaluate the risks of C release caused by human actions, through the assessment of the changes in ecosystem functionality. The specific aims are to study the effect of pollution on forest cover and soil buffering capacity, to assess the effect of silvicultural practises on the dynamics of carbon and on the preservation of productive soils, and to evaluate the effects of revegetation where the original forest cover has been destroyed by open mine exploitation. All the data obtained will be used to forecast changes occurring at short and medium term scenarios, by developing, adapting and validating specific models. The technical issues of the project will lead to the development of a summary of best practises to protect the podzolic environment capacity as a carbon sink.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Making microarrays rational - computational prediction of DNA duplex stability' under Sixth Framework.

assistant: **Concept**

DUPLEX focuses on non-covalent interactions, which are pivotal in self-assembly and supra-molecular chemistry. We address the fundamental question of the nature of the stability of oligonucleotides (and ultimately DNA itself) based on model ab initio calculations. Since stability is not just due to intrinsic features and substituent effects in the gas phase we will link our work with molecular simulation studies. We will constantly contrast our findings with the extensive literature study on MD and MC simulations of oligonucleotides that we carried out already. However, due to the enormity of the central question and the limited time scale we will not perform simulations ourselves. Furthermore we envisage interacting with the large experimental group of a colleague in the School of Chemistry, called Prof DB Kell.His lab has expertise in measuring melting curves obtained by UV spectrophotometry and microcalorimetry. This proposal builds on a paper we recently published in J.Am.Chem.Soc. [vol.124, p.8725 (2002 )] There are three objectives: (1) Determine the validity of Jorgensen well-cited secondary interaction hypothesis for a sizeable set of modified bases. (2) Establish the effect of substituent effects on the stability of H-bonded base pairs. (3) Via ab initio calculations estimate stacking interaction energies for natural bases and N6-methyladenosine and 5-methylcytosine.Very recently computing power has reached the level where benchmark energies for a variety base pair configurations can be obtained from first principles. With state-of-the-art ab initio calculations we will obtain insight into pi-pi stacking for smaller model systems and at lower level for ribose/phosphodiester-linked base pairs. The rigorous partitioning theory called Quantum Chemical Topology wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how '3D Hydrogel Microwell Arrays to Control Cardiac Differentiation of Human Pluripotent Stem Cells in a High Throughput Manner' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The research objective of the project is to develop synthetic materials to control the differentiation of human pluripotent stem cells (hPSCs) (which comprise human embryonic stem cells and induced human pluripotent stem cells) suitable for clinical use using a combination of synthetic polymer chemistry, hPSC culture and high throughput materials characterization.This project brings together a talented researcher with experience in polymer chemistry and surface chemical analysis and a multidisciplinary research and industrial partnership in internationally leading materials discovery and cell culture technologies. The resulting training program will deliver high quality career development in the area of regenerative medicine, tissue engineering and materials science with wide applicability within the EU and internationally.This project will aim to improve ‘start of the art’ technologies by offering an innovative array of materials that not only present a range of moduli but also a diverse range of chemistry. This will enable the identification of instructive hydrogels by controlling a range of physiochemical parameters that has not been previously explored simultaneously.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Eco-Solar Factory - 40%plus eco-efficiency gains in the photovoltaic value chain with minimised resource and energy consumption by closed loop systems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

EcoSolar envisions an integrated value chain to manufacture and implement solar panels in the most ecologic way by maximising resource efficiency, taking into account reuse of materials during production and repurposing solar panel components at end of life stage. EcoSolar will demonstrate that during the lifetime of a solar electricity producing field, individual panels can be monitored, allowing to identify defaulting panels at an early stage, replacing or repairing them and thus to increase the overall energy yield. In WP1, SINTEF&Norsun will work on recovery & reuse during silicon ingot crystallisation, addressing recovery of argon purge gas and work with Steuler on reusable crucibles. In WP2 Garbo will recover Si-kerf-loss during wafering, and with SINTEF work on potential reuse applications, like as Si-feedstock in crystallisation processes, or as resource in crucible manufacturing or lithium ion battery production. In WP3, ISC&SoliTek will look into potential for re-using process water; reducing material resources, like chemicals and silver, by smarter solar cell design, more efficient processes and recovery and reuse of chemicals; AIMEN will develop solar cell monitoring and repair for inline processing in an industrial plant, to enable remanufacturing. In WP4 Apollon will use a module design that results in reduced bill of materials, enables remanufacturing and reuse of components from modules that showed failures after assembly or have been identified as malfunctioning in operating PV installations, based on integrated diagnosis techniques for the detection of failure modes.bifa will collect data from all previous WPs to assess environmental impact of the intended innovations (WP5). Bifa will identify waste streams that are costly and hard to recycle and find
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The UHTHE/EFCC/J1 Project: design, realization and testing of an ultra high temperature heat exchanger module for industrial applications' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Objectives The objective is to develop an Ultra High Temperature Heat Exchanger (UHTHE) based on a modular design to be applied in the consumption peak of around 1450°C, typical for some industrial applications. New construction materials are candidates and in particular ceramic matrix composites (CMCs), for reasons of process efficiency and reliability in operation. The component will modernize industrial installations and produce innovative high temperature technologies in industries, due to the great benefits of recovering heat wasted at high temperatures. The potential use of the component in energy and process industry-related applications will be investigated. Technical Approach Starting from the process requirements identified for both process industry-related and energy-related applications, a complete study of a shell and bayonet-tubes exchanger is carried out. The project encompasses three technical areas : - Application & Requirements : analysis of various industry and energy related applications and definition of the UHTHE process and functional requirements. - Design. The UHTHE module is designed by means of both computer codes developed ad hoc, and 3-D CFD (Computational Fluid Dynamics) and FE (Finite Element) structural commercial codes. - Characterization & Testing. The characterization phase is mainly devoted to bench scale tests regarding fouling/corrosion, heat intensificatioin devices and joinings; in details the tests concern : . scaling/fouling in a coal combustion environment (in a large scale 0.5 MW furnace); . process intensification devices (in bench scale tests, with cold and hot fluids); . reliability of the tube-to-tubesheet joints (in hot pressurised tests) Expected Achievements and Exploitation The main outputs of the project are : - A con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dissection of an evolutionary conserved RNA silencing mechanism in Arabidopsis' (2002-2006).

assistant: **Innovation**

RNA-based silencing mechanisms were first recognised from descriptions of co-suppression in transgenic plants and of RNA interference with double stranded RNA in C. elegans. Recently it had become apparent that both experimental silencing mechanisms recapi tulate a natural evolutionary conserved RNA-mediated silencing mechanism. This mechanism is present in all phyla of eukaryotes and can be placed in at least three pathways: 1) cytoplasmic short interfering (si)RNA silencing, 2) micro (mi)RNA silencing, and 3) nuclear siRNA silencing. Argonaute (AGO) proteins have been implicated with all three RNA silencing pathways in plants, animals and fungi. It seems likely that AGO proteins are integral components of the RNA silencing mechanism. In this proposal it is proposed to further investigate silencing pathways by focussing on the AGO proteins in Arabidopsis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Distributed and prepared. A new theory of citizens' public connection networks in the age of datafication'.

assistant: **Innovation**

In the last decade, societies across the world have been challenged by fragmenting public debate, fueled by algorithmically steered social media and new threats of propaganda and misinformation. The dual tendency of political apathy and polarization pose grave problems for a well-functioning democracy. As the social sciences appear unable to mitigate the challenges with a seemingly ignorant and passive citizenry, PREPARE proposes a radically new approach.  PREPARE fills a research gap on the impact of algorithmic media and datafied everyday life on citizens? potential for political engagement. Current research on people's connection to the public is predominately interested in measuring the political knowledge of so-called ""informed citizens"", or studying the everyday micro-aspects of news media use. The leap proposed by PREPARE changes the focus from each citizen's ""informedness"" to develop and test a groundbreaking theory of distributed preparedness, building a cohesive theory for a fragmented field.  PREPARE will stake out a new path for research on citizens? role in democracies. The project will develop a feasible, normative theory of citizens? orientations to the sphere of politics in datafied societies: their networks for public connection. PREPARE's research questions concern 1) how people stay prepared to engage with public issues, and 2) what resources they need to move from stand-by to engage. PREPARE substantiates the new theory through thickening of big data, with three ethnographies integrated with digital methods, of so-called disconnected citizens. The three groups are young urban immigrants, rural manual workers, and women outside the labour market.  The path cleared by PREPARE allows research to constructively engage with improving democratic societ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Evaluation of a Strategy to Control the Epidemic of Cesarean Sections in Latin America' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Main project:To evaluate, within the framework of a randomized trial, the effect of an intervention aimed at reducing Caesarean section (CS) rates in Latin America. The intervention consists of the two following: (i) systematic second opinion before surgery (ii) practitioner education about decreasing CS rates through alternative guidelines for effective and safe management of childbirth.Furthermore:* Exploratory assessment of rates and needs of CS in Africa and Asia* Dissemination of results of a study of maternal needs and demands concerning childbirthExpected OutcomeThe main project & appended proposals:The main project will assess the effectiveness of a package of co-interventions aimed at curbing the excess rate of CS in Latin America. Should this prove effective, replicating the interventions should not be an issue, as they are mainly behavioural, and therefore their extension to routine care should be neither costly nor complicated. Should the interventions not be effective within the framework of this trial, further assessment of the determinants of the failure will be essential and further in-depth work along the Bradby study would be recommended.Main project:The efficacy of the intervention will be assessed in a multicenter cluster randomized controlled trial with two (three) further nested studies: (i) assessment of women's opinions (ii) care-giver's opinions (this survey is optional) and (iii) organisational and cost survey.In maternity units randomized to the intervention arm, practitioners will systematically discuss the indication for caesarean section with a colleague before resorting to surgery (see a second opinion) and fill in a special form. Educational seminars on ways of decreasing CS will also be organised for the care-givers in the intervention a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Dramatically improving chronic knee pain from osteoarthritis using an active steering telescopic microcatheter device in conjunction with a new ultra-low friction hydrophilic coating'.

assistant: **Concept**

Chronic knee pain from osteoarthritis (OA) is prevalent in 12% of the global population over the age of 60 (Yuji Okuno,Amine Korchi, Takuma Shinjo, Shojiro Kato, Takao Kaneko, 2017). OA results in a loss of mobility and debilitating pain inthose effected. It can ultimately lead to invasive knee replacement or reconstruction surgery. OA is responsible for more than6 million steroid and non-steroid based knee injections globally each year. It is among the top three reasons, globally, forboth opioid and nonsteroidal anti-inflammatory drug prescriptions.Given the well documented economic benefit that comes with restored mobility in patients, the negative side effects ofcurrent drug treatments (addition for opioids and gastrointestinal complications for NSAIDs), the expense and recovery timeassociated with surgery, and the high ongoing cost of drug therapy, a new treatment paradigm for osteoarthritis is certainlyneeded.The end product is a device will allow Interventional Radiologists to reach deep into the anatomy and safely deliver targetedembolisation treatment to this patient population. It will operate and treat in arteries that are significantly smaller than thosecurrently treated.The treatment has the potential to generate a €2Bn saving from the global healthcare spend and delivery meaningful longterm pain relief for up to 90% of those treated.