RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Chemo-enzymatic synthesis of complex carbohydrates - discovery of new enzymes using fluorescence-tagged substrates and fourier transform ion cyclotron resonance mass spectrometry' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content The objectives of the research new glycosidases with specificity for the creation of B1->3, 1->4, or or 1->6 linkages to lactosamine derivatives from N-acetylglucosamine to create linkage types of importance in glycobiology. An approach combining detection of specific hydrolytic activity towards the target Resonance Mass Spectrometry (FTICRMS) will be developed. Enzymes detected by the hydrolytic mode of screening will then be tested for their synthetic capabilities, again using fluorescence-tagged substrates with FTICR-MS confirmation of product structures. Training content (objective, benefit and expected impact)  I will receive training in novel assay methods for the discovery of glycosidases useful for the synthesis of complex carbohydrates. The project will also give me experience in conventional chemical methods for oligosaccharide synthesis and in many advanced analytical techniques, particularly FTICR-MS. Links with industry / industrial relevance (22)  The project will be of great interest to workers in glycobiology interested in the role of the glycosyl components of glycoproteins, many of which are in industrial laboratories. The host group at Warwick has extensive links with industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SustainabLe sUCcinic acid production using an integRAted electrochemical bioreactor and renewable feedstock' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

LUCRA will exploit the EU’s underutilized and abundant, Municipal Solid Waste and Wood waste as feedstocks for the large scale production of platform building block biobased chemicals at high yield with significant industrial end-user interest using a circular bioeconomy biorefinery approach. It will provide optimized and scaleable ‘breakthrough first of a kind’ innovative technology to create a step change from pilot to large scale integrated fermentation with novel electrochemical extraction of succinic acid (SA) at TRL7 that will facilitate its industrial implementation, business models and market feasibility.  This will be achieved by the circular utilization of the mentioned renewable resources as feedstocks which will reduce to a large extent the dependence on fossil resources and achieves at the same time a sustainable SA production route. To fit the needs of the industrial level, LUCRA will optimize the hydrolysis process of the different feedstocks to obtain efficient cellulose and hemicellulose conversion. Enzymatic cocktails will be demonstrated aiming to maximize hydrolysis of fermentable carbohydrate content with low inhibitors production. The crude sugar-rich hydrolysates will be used as fermentation feedstock in an electrochemical membrane bioreactor for efficient extraction and production of SA. In situ extraction of SA will be achieved through an anion exchange membrane resulting in simultaneous acidification, concentration, lower NaOH consumption for pH regulation and less unit operations for SA purification. To demonstrated the produced SA that will be able to compete directly their fossil-based counterparts from petrochemical processes, different polyurethane dispersions and resins will be produced at semi-industrial scale. The process implemented in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Lysine Acetylation: The Scope and Function in Gene Activation'.

assistant: **Concept**

Transcription, the first and most crucial step in decoding the genome, is orchestrated by an extensive repertoire of transcription factors (TFs). These TFs transmit diverse signals to the nucleus, directing precise temporal and spatial gene activation programs. They employ a diverse array of transcription coactivators to impact transcription, including lysine acetyltransferases (KATs), an evolutionarily conserved group of coactivators found in all eukaryotes. Lysine acetylation serves as a hallmark of active promoters and enhancers, with the level of acetylation correlating with gene expression. Despite a strong correlation between acetylation and gene activation, the causal role of acetylation in transcription activation remains debated. Our recent research has revealed that inhibiting the catalytic activity of CBP/p300 acetyltransferase halts the transcription of numerous genes without impacting DNA accessibility or TF binding. A fundamental question that remains unanswered is whether acetylation is directly involved in gene activation, what the nature of acetylation sites involved is, and what are the underlying mechanisms by which acetylation regulates transcription activation. In ACT-SIGNAL, we will take an integrated approach, combining CRISPR-based gene editing, quantitative proteomics, and genomics to investigate the function of lysine acetyltransferases in proteome-scale acetylation and explore the mechanisms by which acetylation promotes gene activation. Ultimately, ACT-SIGNAL aims to establish an integrated model for acetylation-dependent dynamic gene regulation. This endeavor has the potential to provide a major conceptual advance in our understanding of how transcription factors and acetyltransferases collaborate to promote transcription activation – the cr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Development of colloidal crystals supraparticles with photonic behaviour'.

assistant: **Innovation**

Photonic crystals can manipulate light and therefore they are believed to switch from laboratory obscurities to innovative basic materials for industrial scale products (new color effect pigments, thresholdless lasers, beam converters, and filters, e.g.). But only three-dimensional photonic crystals can show complete photonic behavior towards light of every direction and polarization. Thus, there is a great demand for such high-tech materials in industry and research, too. Generally, three-dimensional photonic crystals are synthesized in long-duration sedimentation process. In our project Development of colloidal crystals supraparticles with photonic behavior (PHOTECOS)" we will improve the first successful attempts of synthesizing three-dimensional photonic crystals in our labs towards reproducibility, performance, and tuning of the optical properties. The advantage of our approach against common long-term sedimentation process is the ultra-fast production time: by spraying a dispersion of monodispersed (silica) particles on a surface, the solvent of the drops will be evaporated and the spheres will be arranged in close packings due to capillary forces resulting in a so-called photonic supraparticle."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New strategies for bioconjugation to quantum dots. Study of protein-nucleic acids and protein-protein interactions using fluorescence resonance energy transfer through quantum-dot-protein conjugates' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Quantum Dots (QDs) are a relative new semiconductor nanoparticles made from Cd/Se or Cd/Te with a shell of ZnS that have very excellent spectroscopic properties: broad absorption spectra, low photobleaching levels, narrow and symmetric emission bands, high quantum yields and large stoke shifts, which make them very attractive for fluorescence applications and, principally, for research studies in the biomedical field.  The use of nanoparticles in vitro and in vivo has come in parallel with the development of water soluble QDs. However, together with the improvement in the solubility properties, there is a nascent necessity of developing efficient chemoselective methods of bioconjugation.  This purpose is where is addressed this proposal to. We are going to try to use chemoselective ligations to attach peptides and proteins to QDs. In principle, we are interested in oxime, hydrazone reactions and [3+2] azide-alkyne cycloadditions, because it´s known that are very selective and happen with efficient rates at low µM concentrations (~10 µM) forming thermodynamically and kinetically stable products. Moreover, these ligation reactions have been used with success in peptide-peptide and peptide-dye conjugations.  Once we have developed the conjugation methodology, we have in mind to apply it to the study of protein-nucleic acids and protein-protein interactions through the well-known FRET technique (Fluorescence Resonance Energy Transfer). We think that attaching a low number of proteins per quantum dot (around 5-10 protein molecules/QD) we can get high amplifications in the FRET signal, which will allow us to measure thermodynamic parameters like binding constants.  To evaluate the method, we´ll study the system formed by GCN4 (a natural Transcription Factor) and its CRE recog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrated Transactions and Imagination Engineering to Support the Identity value Chain (INTRINSIC)' (INTRINSIC).

assistant: **Innovation**

In the global economy important opportunities are created for regional productions that qualify themselves as unique and identity-rich. These products can reach the global market using Inter-net and the new opportunities of the Information Society, provided these solutions are made available to the SMEs in easy, unobtrusive ways that allow electronic transactions while preserving the rich legacy of evocation and charme of identity productions. The INTRINSIC project is set to deploy a comprehensive solution to this challenging scenario. To this end, INTRINSIC will:Analyse SME actors and processes in two major production fields (identity food and quality handicrafts products) developing and integrating optimal e-business applications and services to support the transactional value chain;Develop and integrate the applications and services that help convey the image and identity of the products, effectively supporting an imagination engineering value chain;Implement the above solutions into Regional Service Centres acting as Application Service Providers where transactional e-business applications are managed and offered to the SMEs by means of lightweight interfaces, while promotional applications are run on behalf of the entire local system, in order to attain integration and critical mass;Perform a two-phase training activity: initially by training, through services and facilities made available by the Associations, the operators of the SME core group; then, at a later stage, by transferring knowledge towards the operators of a larger number of SMEs belonging to the same sectors, through a direct, on the job involvement of the champions of the SME core group.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A novel cost-effective process to produce prebiotics from by-products of the ethanol industry'.

assistant: **Innovation**

Carbiotix isa a Swedish SME that develops and commercializes BioAXOS, a new generation prebiotic from the xylo-oligosaccharides family that is superior to existing alternatives both in terms of organoleptic parameters, health benefits and costs. Carbiotix has designed a cost-efficient and scalable process to produce BioAXOS from side-products of ethanol plants, and has validated it in a trial environment with a Hungarian plant. With this innovation Carbiotix won the 1st prize at the Venture South Cup competition in Sweden.Prebiotics are non-digestible food ingredients that beneficially affect the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria in the colon to improve host health. Prebiotics occur naturally in grains and vegetables, and have been shown by multiple documented clinical studies to reduce the chances of cardiovascular and other diseases.The global market for prebiotics is estimated to grow to €4B by 2018, driven by increased consumer awareness of their health benefits. With 400+ prebiotic-containing foods available right now, and demand for more, there is a clear market opportunity for BioAXOS. In this 6-month feasibility study, Carbiotix will investigate further the commercial feasibility of BioAXOS by approaching major ethanol producers in EU and validate the business model fit.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Snow Antarctic Mean Isotopic Record' (SAMIR) targeting Horizon Europe.

assistant: **Abstract**

The impact of climate change is the largest in polar regions, due to multiple feedback loops leading to polar amplification. In Antarctica, short meteorological time series hamper our ability to evaluate the climate variability at interannual and decadal scale, and in particular the one linked with the anthropogenic climate change. It is also not clear though whether climate variability in polar region will increase, despite significant consequences on the global climate system. In this proposal, I will evaluate how climate variability in Antarctica varies for changing climatic conditions, using ice core isotopic composition (18O, d-excess and 17O-excess). The objectives of this project are to study the climate variability thanks to a large network of ice core records at high resolution and high precision. A large number of ice cores are available through large European projects (Beyond EPICA  Oldest Ice (BE-OI), EAIIST, ) but the analytical platform to measure all this ice at high precision is missing. By implementing the new generation of infrared spectrometer in an ice core measuring line, we will be able to increase both the throughput and precision, and measure triple isotopic composition on a large number of cores and resolve the climate variability in Antarctica.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'RESPONSE of YEAST AND PLANT CELLS TO CHANGES IN EXTERNAL OSMOLARITIES' in the context of a Fourth Framework call.

assistant: **Objectives**

This project aims at improving our knowledge on the response of yeast and important objectives of TMR are met: interaction of disciplines, and plant cells to changes in external osmolarities. We will-employ combination and transfer of technologies. The Institutes to which the Saccharomyces cerevisiae as a microbial model system to unravel the molecular mechanisms underlying the osmoresponse and use these findings to partners in this network belong, all take part in graduate schools, thus examine corresponding processes in the model plant Arabidopsis thaliana. offering ideal opportunities to young visiting researchers for attending the advanced educational programs aimed at improving practical and Particular attention will be paid to the protein kinase cascades and other signalling pathways that are elicited by changes in environmental theoretical skills. The research stays at the expert host laboratories osmolarity. We will study yeast mutants defective in osmosignal will considerably add to the scientific education of the visiting fellows. transduction to elucidate so far unknown components of the osmoresponse and use them to clone corresponding plant genes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Green Surveillance: Imagining a Sustainable Internet of Things' (GREENWATCH).

assistant: **Concept**

The emerging Internet of Things (IoT) constitutes a communication system that enables comprehensive and continuous monitoring of the effects of human activity on Earth’s ecosystems, thus potentially facilitating the green transition to sustainable forms of social life. But the scope and the scale of the necessary monitoring simultaneously entails surveillance, not only of natural and built environments, but of persons and their actions as well, extending far beyond the online tracking of citizens and consumers which over the past decade has generated widespread public debate and motivated substantial legislation regulating digital infrastructures in the European Union and beyond.The GREENWATCH project anticipates and assesses the ethical dilemmas that follow from green surveillance: What kinds and which degrees of surveillance will the present human cohort be prepared to accept in the coming decades to ensure the livelihood of the species centuries and millennia into the future? Comparing the three world regions driving the development of IoT – Europe, the United States, and China – the study maps the empirical scenarios being projected for IoT as part of the green transition; theorizes the process of green surveillance as information feedback to national and international systems of governance as well as to individual citizens, consumers, and corporations; and evaluates both the scenarios and the practice of surveillance against the background of classic philosophical traditions of local and global social justice, complemented by recent conceptions of climate justice and environmental justice. Through IoT, Earth is sending a message that the human species is obliged to respond to, across ideological and civilizational divides, for survival and, at best, individual and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Symptoma, Better Diagnosis for Patients with Rare and Complex Diseases'.

assistant: **Concept**

OUR MISSION is to save 1.5 million lives globally each year by delivering the right diagnosis. SOCIETAL PROBLEM: To err is human. But in medicine, errors cost lives. ""The delivery of health care has proceeded for decades with a blind spot: Diagnostic errors - inaccurate or delayed diagnoses - persist throughout all settings of care and continue to harm an unacceptable number of patients."" - Institute of Medicine. Studies have shown a devastating rate of misdiagnoses ranging from 10 to 40%. Diagnostic errors cause 10% of patient deaths. +20k diseases cognitively overwhelm doctors. Only 3% of doctors are satisfied with existing research tools. Misdiagnoses account for €446 billion in wasted costs in the EU and $750 billion in the US. Solving misdiagnosis could free up 30% of total healthcare budgets globally. Patients with rare diseases suffer most. 22 of 30 million patients with rare diseases in the EU don’t have their diagnosis yet, and 8 million had to wait 10 years in average. This leaves doctors and patients with a high unmet need. SOLUTION: Symptoma.com is a free search engine for diseases. Users enter symptoms and receive a list of matching causes – sorted by probability. COMPETITIVE ADVANTAGE: Symptoma’s diagnostic accuracy has outdone all competitors’ raising the bar for this field as first and only viable solution. We have demonstrated (1) technological success, (2) high demand, and (3) willingness to pay for our solution operating at a profit with pilot customers. OUR GOAL is to improve diagnostic quality while reducing cost and time spent. We will attain this goal by pushing Symptoma to the next level by (deep) learning from search behaviour, asking questions (cognitive intelligence), and overcoming language barriers. This project is the first step towards a