RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Casting of Large Ti Structures' in the context of a Seventh Framework call.

assistant: **Objectives**

This proposal is in response to the call for EU and China collaboration on casting large Ti structures. The consortium consists of 7 EU and 7 Chinese partners. This proposal aims to make a step-change for casting of large Ti components by overcoming some key challenges in the casting process. Such a step-change is critical if the production of large Ti components is to meet the requirement in cost reduction by endusers, the requirement of CO2 reduction and raw material wastage reduction in every step of component manufacturing process by the endusers and by the society. This step change will involve the development of the centrifugal casting process by which the filling of thin sections of large Ti structures will be improved so that significantly fewer and smaller defects will be present in the component and a significantly higher production yield rate will be achieved. Further development will be carried to improve the gravity casting process which is important for casting asymmetrical components such as Ti airframes. Those developments will be closely coupled with the development of computer modelling in terms of better understanding and predicting liquid filling of the mould, defect formation and distribution, control of the dimensional accuracy of the cast component together with the development of a stronger wax and optimum ceramic mould material if required in order to meet the component dimension tolerance specified.  The microstructure and mechanical properties including that of heat treated and welded castings must be optimised. If successful, this project will lead to significant cost reduction in producing large Ti components; removal the USA monopoly of supply of aeroengine Ti casings and significant reduction of CO2 and of Ti raw material wastage incurred
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Fungal diversity, ecosystem services and forest management: unravelling the role and dynamics of fungal communities in multifunctional Mediterranean forests.' (MultiFUNGtionality) under Horizon 2020.

assistant: **Objectives**

Forest fungi are a major biodiversity component of Mediterranean forests, and contribute to providing crucial ecosystem services. Thus, changes in fungal communities driven by environmental factors and human actions on ecosystems may have, ultimately, an impact on human well-being. Understanding and predicting such changes and their subsequent impact on the provision of ecosystem services is crucial to enable scientifically sound decision-making in land–use planning. However, our knowledge on such complex ecological systems is limited due to the high diversity of forest fungi and their cryptic nature. This action aims at addressing such complexity by contributing to unravelling how fungal diversity is affected by several drivers and, in turn, how it affects the provision of multiple ecosystem services to be further integrated into multifunctional forest management. This will be possible thanks to multi-scale, high-quality data on above- and belowground diversity and its potential drivers. Such data will be analyzed using advanced hybrid modelling techniques, and the resulting models will be combined in simulation-optimization routines to enable science-based decision making in forestry sensitive to fungal diversity. This will be the leading thread of an action that aims at having high impact on the research career of Dr. Sergio de Miguel for him to attain a position of maturity as an independent and interdisciplinary researcher.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'FLEXIBLE MICROSYSTEM TECHNOLOGY FOR MICRO- AND MILLIMETRE-WAVE ANTENNA ARRAYS WITH INTELLIGENT PIXELS'.

assistant: **Objectives**

FLEXWIN proposes a significant advance towards smart RF microsystems by combining 1.) an RFMEMS switch process monolithically integrated with a Si/SiGe BiCMOS process, 2.)  highly reconfigurable mm-wave building blocks, able to be used over a broad frequency range and for different applications, 3.) a new RF-system design paradigm built around the concepts of reusability, multifunctionality and reconfigurability and 4.) environmental sensing and control built into multifunctional RF ICs with digital control.As a first demonstrator of the proposed highly innovative FLEXWIN technology platform, a smart reflectarray architecture for broadband communication links will be realized. In fact, the core FLEXWIN ICs will be used as intelligent pixels providing spatial power combining with full individual amplitude and phase settings of each pixel in transmit and receive mode controlled by a serial bus. Together with the monolithic integration of the environmental sensors on the very same IC, it dramatically reduces the antennas control system complexity providing significant advances in RF frontend adaptability.The validity of the design paradigm will be further explored in two reconfigurable IC demonstrators using the RF MEMS SiGe BiCMOS technology and deliberately spaced in the radio spectrum: reconfigurable commodity" building blocks up to 5 GHz, addressing mobile and wireless data applications, and for the 30-64 GHz range, addressing point-to-point, and emerging wireless LAN applications.Overall, FLEXWIN will demonstrate enhanced and smart capabilities of mm-wave systems due to built-in intelligence allowing convenient and flexible control of important parameters, and the use in harsh environments due to built-in sensing and autonomous parameter adjustment in each module. Fur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Functional analysis of the promoter region of the prophenoloxidase gene isolated from the dipteran anopheles gambiae'.

assistant: **Concept**

Research objectives and content Recently, Paul Brey' s group at the Pasteur Institute in Paris sequenced the promoter region of Prophenoloxidase (proPO) gene isolated from the dipteran Anopheles gambiae. They found some interesting regions highly homologous to several responsive elements like ecdysteroid hormone responsive elements, GATA elements etc. At the moment, A. gambiae has the only proPO gene completely sequenced and this study will be important in further studies to render A. gambiae inefficient to harbor the malaria parasite. In this project we want to investigate the functionality of that region of the proPO gene promoter. Furthermore, we want to verify whether this putative regulatory region of the promoter can affect proPO gene expression. Our intention is to use DNaseI footprinting experiments combined with gel shift assay in two inducible systems (the larval haemolymph and a tumorous Drosophila blood cell line (mbn-2)), to investigate the functionality of the regulatory region of the proPO gene promoter. Further, we will use the transfection assay of Drosophila tumorous blood cell to verify a possible involvement of the regulatory region of the promoter in the proPO gene expression. This project will address the very important question as to whether the possible presence of some factor in the haemolymph of A. gambiae affects the expression of the proPO gene in this environmentally important insect: a known vector of human malaria. Training content (objective, benefit and expected impact) This experience will be of great importance for the high quality of research and in the training provided by the host Institute. Moreover, the applicant will learn many techniques of biochemistry and molecular biology which he will in order to complete his scientific trai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mass customization 2.0 for Integrated PV' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In the past 25 years, many integrated photovoltaics (IPV) products have been introduced and demonstrated. Mostly BIPV products, but more recently also IIPV and VIPV products. However, large scale deployment and massive market adoption of these technologies and products have not yet taken place. We are at the brink of a huge scale-up and capacity build-up of PV in Europe, that will have a large effect on our living environment. Therefore, it is now urgent and essential that IPV products become widely available and affordable. This is important (1) to generate solar electricity where the demand is (in the built environment) and (2) to enable multifunctional use of area and space in the built environment. Several parties in the MC2.0 consortium have more than 20 years of experience in IPV development and as such have been involved in many earlier projects and studies. We believe that the number one barrier for large scale market uptake of IPV is the high cost. Other - secondary but also important – barriers are immature sector cooperation and certification issues. The overarching ambition of the MC2.0 project is to demonstrate a cost breakthrough for IPV by means of an advanced manufacturing approach, referred to as “mass customization”. In coherence with this approach, we will contribute to solving the other identified barriers.  To realize this ambition, the MC2.0 consortium brings together experts and companies on materials for PV laminates (including PV cells), on manufacturing of PV laminates, on manufacturing of IPV products and on market and application of IPV products.


**Keywords:** Integrated PV, BIPV, Mass customization, PV laminate, Industry 4.0, cost breakthrough, renovation wave
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Efficient  Proofs and Computation: A Unified Algebraic Approach' (EPRICOT).

assistant: **Concept**

Computational complexity lies at the heart of information and computer science. Its aim is to formally understand the boundary between problems that can be solved efficiently and those that cannot. This has many applications: new algorithms are important to make progress in domains such as machine learning and optimization, and new complexity lower bounds (namely, computational impossibility results) are essential to provably secure cryptography. Beyond practical applications, these questions reveal deep mathematical and natural phenomena. One of the prominent directions to attack the fundamental lower bound questions in complexity comes from the study of resource bounded provability, namely proof complexity. Its aim is to understand which problems possess solutions with short correctness proofs and which do not. Traditionally, proof complexity is concerned with propositional (Boolean) logic, and thus techniques from Boolean function complexity have had a huge impact on the field, driving many of its results and agendas.In this proposal we suggest to employ recent breakthroughs in the field of proof complexity exploiting algebraic approaches to broaden in a systematic way both the scope and techniques of proof complexity, going from weak settings to the very strong ones, up to the major open problems in the field and beyond. In particular, we propose to use algebraic notions and techniques such as structural algebraic circuit complexity, rank lower bounds, noncommutative and PI algebras, among others to significantly broaden the arsenal of lower bound tools as well as develop new models and insights into proofs, computation and their inter-relations.This project has potential for a transformative impact in theoretical computer science and beyond, with applications to un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'An induced pluripotent stem cell-based neuronal model of Spinocerebellar ataxia' (2014-2020).

assistant: **Concept**

The spinocerebellar ataxias (SCAs) are a diverse group of neurological disorders defined by a loss of motor coordination. No effective treatments exist, and there is thus a pressing need for suitable models in which to study disease progression and to screen potential therapies. Induced pluripotent stem cells (iPSCs), which are capable of differentiation into any cell type of the body, offer the opportunity to study neurodegeneration in vitro. The proposed study aims to be the first in Europe to establish an iPSC-derived model of cerebellar disease, focusing on two genetic subtypes of SCA - SCA14 and 41. Increasing evidence points towards common pathological pathways shared across multiple SCA subtypes, which could provide novel therapeutic targets. There is also evidence to suggest that abnormalities in Purkinje cell development may contribute to the pathogenesis of the SCAs. This model will thus be used to elucidate the molecular mechanisms underlying common SCA-causing disease pathways, and to unravel the neurodevelopmental aspects of these diseases, in order to develop early-intervention therapies. Preliminary results indicate successful differentiation of iPSCs into cerebellar progenitor cells, using a protocol I have optimised. Following terminal differentiation, these cells will be investigated for common disease phenotypes and developmental defects, using a combination of transcriptomic, biochemical, and electrophysiological methods. Results will be validated by comparison with post-mortem brain samples and ataxic mouse models. By adapting this differentiation strategy to a format amenable to high-throughput screening, a pipeline will be established for the identification of novel therapeutic compounds. This groundbreaking study will enable the investigation of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Complex Socio-Technical System in Ambient Intelligence' (SOCIONICAL) under Seventh Framework.

assistant: **Objectives**

We will develop Complexity Science based modelling, prediction and simulation methods for large scale socio-technical systems. We focus on the specific example of Ambient Intelligence (AmI) based smart environments. A key component of such environments is the ability to monitor user actions and to adjust its configuration and functionality accordingly. Thus, the system reacts to human behaviour while at the same influencing it. This creates a feedback loop and leads to a tight entanglement between the human and the technical system. At the same time there is dynamic, heterogeneous human-human, human-technology, and technology-technology communication leading to ad-hoc coupling between components and different feedback loops. The project will study global properties and emergent phenomena that arise in AmI based socio-technical systems from such local feedback loops and their coupling on two concrete scenarios: transportation and emergency/disaster.SOCIONICAL takes a parallel, multi facetted  research approach. Thus, we will investigate analytical methods, complex networks based representations, and agent based models. The advances in modelling and prediction will be verified by large scale, distributed simulation  driven by real life data. We will develop a methodology by which a small number of instrumented users can be realistically integrated in a large scale simulation as additional 'agents', experiencing the system and driving it. A separate WP is devoted to the integration of different approaches into a coherent framework. Another ensures generalization.To take into account all technological, psychological and social dimensions and realistic diversity of behaviours we have assembled a multi disciplinary consortium with  separate WPs  for technology analysis and th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mapping of systemic lupus erythematosus - sle - susceptibility genes by linkage disequilibrium in the unique Finnish population' (1994-1998).

assistant: **Concept**

The objectives of this proposal are to map susceptibility genes predisposing to SLE in the Finnish population, and to determine the general feasibility of linkage disequilibrium (LD) mapping strategies for the identification of complex disease susceptibility genes in a genetically homogenous population. A novel approach based on the special genetic features of the Finnish population, namely the extensive LD found between individuals, is proposed. The project entails the systematic genotyping of DNA samples from over 200 Finnish SLE families with microsatellite markers to identify shared genomic segments of LD by analyzing human homologous regions containing candidate genes implicated in previous SLE studies and by performing a genome-wide search. Statistical analysis of the obtained genotype data for allele and haplotype associations with the disease in affecteds and controls will identify candidate SLE susceptibility gene regions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Functional consequences of estrogen receptor alpha acetylation in hormone-regulated transcription' (2002-2006).

assistant: **Concept**

Estrogen receptors (ERalpha and ERbeta) function as ligand-regulated transcription factors that mediate the physiological effects of estrogen hormones. In addition to ligands, the activities of ERs can be modulated by post-translational modification. ERalpha (ERa), for example, is subject to phosphorylation, ubiquitylation, sumoylation, and acetylation.Recently, the Kraus lab has identified two lysine residues in ERa that are the sites of acetylation by the p300 acetyltransferase. The lab has also shown that acetylation of these lysins by p300 increases the DNA binding and transactivation activities of ERa. Although these initial results establish a role for acetylation in regulating the activity of ERa, additional studies are needed to clarify the role of acetylation in ERa biology.The broad hypothesis of my proposed studies is that transcriptional outcomes in estrogen signalling pathways are ultimately determined by receptor and accessory factors, including the covalent modification state of ER and the cell type-specific repertoire of enzymes that control those modifications.More specifically, I hypothesize that acetylation of ERa has the potential to impact the molecular activity of the receptor at enhancer elements, response to ligands, crosstalk with other signalling pathways, and ultimately gene regulation in estrogen signalling pathways.In this proposal, I outline a series of experiments using biochemical, cell-based, and genomic approaches in both cell and animal models in order to determine the:- Effects of ERa acetylation on estrogen-regulated gene expression,- Mechanisms of ERa acetylation/deacetylation, and- Effects ERa acetylation on the mitogenic and tumourigenic effects of estrogens, and the antagonistic actions of SERMs.Collectively, these studies will s