RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding prion strains and species barriers and devising novel diagnostic approaches' (STRAINBARRIER), addressing dissemination and exploitation.

assistant: **Impact**

The existence of stable strains of prions, differing in incubation times, clinical features, and neuroanatomical PrPSc deposition, is disquieting. The structural and biological features which encode strains and determine their disease phenotype are obscure. Some strains, including BSE, easily traverse species barriers causing serious concerns in the EU. Promiscuous strains present a public health threat if they propagate through the food chain, while remaining either undetected or misidentified. These dangers are illustrated by the atypical cases of scrapie which have appeared throughout the EU, including in sheep hitherto considered genetically resistant, and by the identification of BSE in a goat in France. As yet there are no diagnostic procedures to identify TSE strains, except in some rare cases. We propose studying fundamental and applied aspects of prions strains and their relationship to the species barrier, and to use the knowledge generated to initiate diagnostic methodologies to detect strains and predict their epidemiological behaviour. We have assembled a powerful consortium of partners with proven experimental and industrial achievements. We will (i) systematically examine the properties of field strains and their species barriers when propagated (ii) examine strain-dependent biochemical and biophysical properties of PrPSc (iii) apply novel cryoelectron tomographical techniques to determine the 3-D structure (at 4 nm resolution) of PrPSc in various strains in neuronal (stem) cells (iv) study strain-specific features of prion infection in cultured cells, including their uptake receptors, (v) characterize strain dependent cytopathogenic mechanisms in infected cells. We will prepare novel diagnostic and research reagents such as a) possibly strain specific, P
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'The characterisation of molecular ions by infrared spectroscopy'.

assistant: **Concept**

Ion-molecule reactions in the gas phase are very fast, dominant processes. They are important in the understanding of widely differing environments such as discharge plasmas, the ionosphere and interstellar medium. Because of the ephemeral nature of ionic species their structure and properties are rather poorly characterized and there is a need for much more experimental observation in this area. Spectroscopic work over the last ten years has produced a rapid development of our knowledge of molecular ions, mostly through laser sampling of extended glow discharges. The present proposal falls in this area. A new microwave discharge source for the generation of transient species has recently been developed. We propose to modify this source so that it can be used in the mid-infrared region. A carbon monoxide laser magnetic resonance spectrometer, working in the frequency region 1250-2080 and 2500-3500 cm-1, is already in existence in Dr. Brown's laboratorv in Oxford. We would aim to detect the bending fundamental band of H2O at 1408 cm-1 as a proving experiment. After that, we would search for new species such as HO2+ and CH2+ about which essentially nothing is known.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SPATIOMIND SHOP FLOOR TOOLS' (2021-2027).

assistant: **Innovation**

nebumind is a German company founded in 2019 with the vision to use the growing amount of data available in production companies to increase the quality of manufactured products and facilitate the shift toward Industry 4.0  nebumind is the result of the combined experience of its two co-founders Franz and Caroline. They have spent over 13 years working in aerospace manufacturing and have gained an in-depth understanding of production methods, sensor technologies, quality monitoring, and data processing. Before founding nebumind, they jointly built up and managed the Airbus subsidiary InFactory Solutions, developing online sensor systems. During that time, Franz and Caroline sensed that manufacturing quality still had great potential for improvement because is often based on experience and intuition. This gives room for interpretations and results in limited improvements during running production, acceptance of recurring scrap, and flat learning curves. So, they developed Spatiomind, the first software on the market, making quality analyses during manufacturing economical for production companies. Spatiomind’s unique selling point is based on the innovative data search engine, developed internally, which can reduce data/information search by a factor of 1 billion compared to conventional solutions. It enables manufacturers to retrieve quality data very efficiently on any manufactured component, display it in an intuitive 3D visualization for first insights and use it for the implementation of more automated quality control and improvement processes in productions. Spatiomind is suitable for aerospace, automotive and semiconductor’s manufacturing and has raised the interest of industries. It  has been validated in pilot with large manufacturing companies, including Airbus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'CleanTechBlock' (CleanTechBlock) targeting Horizon 2020.

assistant: **Abstract**

The building sector contributes with about 40% of total energy consumption in Europe, thus holding an immense potential for contribution towards CO2 emission reduction and energy savings. Graasten Brickworks aims to address this potential and gain access to a major market opportunity through the development of an innovative building material – CleanTechBlock - which will enable a paradigm shift within the construction process and recycling in Europe. CleanTechBlock is a patented multifunctional sandwich-block solution based on the combination of two clay brick shells and foamed recycled glass. The advantages of CleanTechBlock over bricks are compelling as the insulation, strength properties and construction price are similar to alternative solutions and it offers an overall increase in the inner space (3-5%) and a potential reduction in the overall house wall construction time (5x faster), while reducing maintenance requirements. In addition to the economic benefits, it can contribute to the mitigation of environmental problems – increase of waste recycling and decrease of raw material consumption, energy consumption and CO2 emissions (more than 50%). Our vision is to take the final steps of technological development and maturation towards industrial scale production of CleanTechBlock leveraging on the opportunity provided by the SME instrument. Besides giving the participating companies a technological leap with the consequent competitive advantage and export potential, the project will strengthen GB´s position in the clean-building materials field and assist Europe in achieving objectives for environmental and energy policy, both in terms of waste recycling and general reduction of CO2 emissions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'OPTICAL PROGRAMABLE ASSEMBLY OF NANOMATERIALS'.

assistant: **Objectives**

Recently, I have pioneered the development of a technique of light-induced reconfigurable nanostructured materials. This process consists of the displacement of the nanostructures inside a solid host medium with the action of light. When an incident light beam interacts with the nanostructures, a photon momentum transfer takes place. This momentum serves to displace/rotate the nanostructures inside the medium. During the writing process, the standing waves can assemble complex patterns in a reversible fashion. My research plan includes both the theoretical and experimental aspects of this light-induced self-assembly phenomenon. Theoretical developments will provide an insight into the effect that standing light waves have on embedded nanoscale objects. It is necessary to model the optical, mechanical and thermal characteristics of materials to identify the optimal conditions for low energy assembly of complex nanostructured architectures. Experimentally, I aim to demonstrate the assembly of a metamaterial consisting of crystal nanostructures through standing waves of both, linearly and circularly polarized light. This device will function as an active wave plate that can rotate the polarization of incident light. Subsequently, I will fabricate and demonstrate a tunable laser device by arranging nanoparticles into photonic crystal-like structures. Standing waves will be employed to record multilayer assemblies that will act as resonant cavities. The addition of a fluorescent organic dye, quantum dot or perovskite nanocrystal dispersed into the multilayer structure will provide the necessary conditions to induce stimulated emission to produce laser light. This project will set the ground for the fabrication of low-cost composites for photonic crystals for programable lase
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The strength of wood fibres. Association between hemicellulose and cellulose at the molecular level' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The strength of heterogeneous fibres such as wood is largely determined by the strength of association between hemicellulose and cellulose. Understanding the association at the molecular level permits a rational evolution of pulping processes, and opens new avenues to the development of designer-made fibres based on agricultural products. In this multi-disciplinary project the association between hemicellulose and cellulose fibres will be studied at several levels of molecular detail, both experimentally and theoretically. Hemicelluloses such as glucomannan and xyloglucan bind tightly to cellulose in a very specific patterns. The co-crystallization reduces the number of accessible conformations, which will lower the conformational entropy. The driving force behind efficient binding are hydrogen bonds. These interactions are highly specific, setting high demands on structural complementary. For flexible polymers such as carbohydrates structural changes upon association of the polymer to the substrate can be expected. For small carbohydrate complexes these structural changes are observed. For these small systems desolvation entropy contributes significantly to the affinity, which is probably even larger for polymeric systems. All these issues (specificity, structural changes, entropic effects, desolvation) will be addressed in varying molecular detail to obtain a comprehensive understanding of hemicellulose-cellulose association. The methodological approach is based on state-of-the-art physico-chemical methods. Energetic aspects of the association between hemicellulose and cellulose will be studied by binding assays of radioactive labeled oligomers. Isotherms valid for all densities validated by these experiments will be derived from models with molecular detail, which wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Liquid Chromatography-Ion Mobility-Mass Spectrometry and Capillary Electrophoresis-Mass Spectrometry as ground-breaking approaches to expand the boundaries of metabolomics in chemical risk assessment' (HAZARDOmics).

assistant: **Innovation**

Nowadays, there is a growing concern in the research community and civil society in general about the effects of chemical exposure on human health. From a public health perspective, it is of major interest to establish the risks associated with chemicals for the enforcement of health prevention strategies. In this sense, one of the current priorities of chemical risk assessment is to understand the effects and modes of action (MoA) of endocrine disruptor compounds (EDCs) such as bisphenol A (BPA) and polychlorinated bisphenyls (PCBs). Within this framework, metabolomics has emerged as a novel strategy for the discovery of effect biomarkers that can provide the connection between exposures to EDCs and chronic diseases.HAZARDOmics aims to enhance the knowledge about the risks arising from exposures to low doses of BPA and to a ‘cocktail’ of PCBs following an innovative metabolomics approach. The metabolic profiling of blood serum samples will be investigated from a broad analytical perspective in order to obtain the most complete information of metabolic fingerprint and, consequently, to increase the possibility of identifying effect biomarkers. Liquid chromatography (LC)-High Resolution Mass Spectrometry (HRMS) involving Reverse Phase Liquid Chromatography (RP-LC) and Hydrophilic Interaction Liquid Chromatography (HILIC) will be employed as traditional metabolomics strategy in risk assessment. On the other hand, the boundaries of this approach will be extended by the application of two additional techniques. For the first time, Ion Mobility Spectrometry (IM) integrated in a LC-HRMS workflow will be evaluated as a ground-breaking technology for metabolomics intended to risk assessment purposes. Moreover, Capillary Electrophoresis (CE)-HRMS will be implemented as complemen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Software quality founded on design laws' (SQUFOL).

assistant: **Innovation**

As size and complexity of software systems is growing dramatically the possibility of crises from failure increases. Conventional methods for measuring and controlling quality are not successful enough, thus our objective is to use the science of complexity, the theory of chaos, fractals, traditionally 'physically based' methodologies, theory of complex adaptive systems, biologically and evolutionary inspired economic/market theories, intelligent data analysis and data mining to gain a fundamental understanding of the software process and the software products and to improve them. As a consequence the SQUFOL aim is to introduce well understood software design processes leading to software and related products of superior quality thus improving European competitiveness and enabling citizens to use better software more effectively. As size and complexity of software systems is growing dramatically the possibility of crises from failure increases. Conventional methods for measuring and controlling quality are not successful enough, thus our objective is to use the science of complexity, the theory of chaos, fractals, traditionally 'physically based' methodologies, theory of complex adaptive systems, biologically and evolutionary inspired economic/market theories, intelligent data analysis and data mining to gain a fundamental understanding of the software process and the software products and to improve them. As a consequence the SQUFOL aim is to introduce well understood software design processes leading to software and related products of superior quality thus improving European competitiveness and enabling citizens to use better software more effectively.OBJECTIVESSQUFOL's objective is to significantly improve the basic knowledge about and the fitness and quality of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Chemistry and Interface Control of Novel 2D-Pnictogen Nanomaterials' (2D-PnictoChem).

assistant: **Innovation**

2D-PnictoChem aims at exploring the Chemistry of a novel class of graphene-like 2D layeredelemental materials of group 15, the pnictogens: P, As, Sb, and Bi. In the last few years, these materialshave taken the field of Materials Science by storm since they can outperform and/or complement grapheneproperties. Their strongly layer-dependent unique properties range from semiconducting to metallic,including high carrier mobilities, tunable bandgaps, strong spin-orbit coupling or transparency. However,the Chemistry of pnictogens is still in its infancy, remaining largely unexplored. This is the niche that2D-PnictoChem aims to fill. By mastering the interface chemistry, we will develop the assembly of 2Dpnictogensin complex hybrid heterostructures for the first time. Success will rely on a cross-disciplinaryapproach combining both Inorganic- and Organic Chemistry with Solid-state Physics, including: 1)Synthetizing and exfoliating high quality ultra-thin layer pnictogens, providing reliable access down tothe monolayer limit. 2) Achieving their chemical functionalization via both non-covalent and covalentapproaches in order to tailor at will their properties, decipher reactivity patterns and enable controlleddoping avenues. 3) Developing hybrid architectures through a precise chemical control of the interface,in order to promote unprecedented access to novel heterostructures. 4) Exploring novel applicationsconcepts achieving outstanding performances. These are all priorities in the European Union agendaaimed at securing an affordable, clean energy future by developing more efficient hybrid systems forbatteries, electronic devices or applications in catalysis. The opportunity is unique to reduce Europe’sdependence on external technology and the PI’s background is ideally suited
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Circadian regulation in the control of insulin and glucagon release and its role in Type 2 diabetes' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Diabetes Mellitus is considered a bihormonal disorder that involves insulin resistance and insulin deficiency as well as relative or absolute high levels of glucagon. Recently, a strong association has been found between disturbances in circadian rhythms and metabolic disorders such as Diabetes Mellitus and Obesity. In this proposal we will use in vitro techniques to knockdown several clock genes in mouse pancreatic islets, MIN6 and alpha-TC1-9 cell lines to establish the role of clock genes in insulin and glucagon secretion. We will examine the circadian regulation in type 2 diabetes in db/db mice to determine whether disturbances in insulin and glucagon secretion are due to disregulation of circadian rhythm in the pancreas. We will also examine the effect of nutrients in the expression pattern of clock genes by performing in vivo studies in mice. Thus, the overall aim of this proposal is to determine whether clock genes can regulate the secretion of insulin and glucagon and whether pancreatic circadian clock can be involved in the irregular secretion of these hormones in Diabetes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Dynamics in Buddhist Networks in Eastern Central Asia, 6th-14th Centuries'.

assistant: **Objectives**

The objective of this proposal is to create a new framework to enable understanding of the complexities in the dynamics of cultural encounter and religious transfer in pre-modern Eastern Central Asia—the vast area extending from the Taklamakan desert to Northeast China. This region was the crossroads of ancient civilisations. Its uniqueness was determined by complex dynamics of religious and cultural exchanges gravitating around an ancient communication artery, known as the Silk Road. Buddhism was one major factor in this exchange; its transfer predetermined the transfer of adjacent aspects of culture. The religious exchange involved a variety of cultures and civilisations, which were modified and shaped by their adoption of Buddhism. This process overrode the ethnic and linguistic boundaries of the Buddhist universe. One specific aspect of this process was the rise of the local forms of Buddhism. This project intends to investigate such Buddhist localisations between the 6th–14th centuries. I will create a new trans-regional and trans-cultural vision of the religious transfer in Eastern Central Asian history and will reconstruct this Buddhist network with its entities and relations. It will incorporate the fascinating, but as yet under-researched field of Eastern Central Asian Buddhism into a broader research agenda of Comparative Religious Studies. It will establish a new research approach by bringing together many research fields and agendas (such as Philology, Art History, Archaeology, Religious Studies) into one synthesising narrative based on a unique perspective, in which, religious exchange in Eastern Central Asia will be analysed as a dynamic network emerging in its spatial and temporal aspects. For the first time the multi-layered relationships between the tra