RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Integrating outcome registers, retrieval analysis programs and preclinical validation methods into a synergistic post-marketing surveillance program for orthopedic devices'.

assistant: **Objectives**

There is increasing demand for technology to maintain the mobility of an aging worldwide population.  Joint replacement is widely recognized as a successful orthopaedic surgical procedure for treating degenerative musculoskeletal conditions.  However, joint replacement prostheses have limited longevity, especially in younger and more active people.  Efforts to improve prosthesis longevity and performance continue to drive changes in surgical techniques, prosthesis materials and designs. The broad objective of this proposal is to improve the longevity of joint replacements by expanding our understanding of the biomechanical environment in which prostheses function and wear.  The approach is to assess the performance of explanted prostheses after they have endured a finite duration of function in a human physiological environment.  Such assessments provide essential inputs for prosthesis development and for validating preclinical methodologies for predicting joint prosthesis performance.  However, access to explanted prostheses is limited and few European research groups are participating in such assessments.  This proposal (ORTHOWATCH) aims to strengthen the procedures and outcomes of a recently established Register of Orthopaedic Prosthetic Explants (REPO) at the Istituti Ortopedici Rizzoli, a leading European institute for orthopaedics and traumatology.  ORTHOWATCH will integrate outcome registers, retrieval analysis programs and preclinical validation methods into a synergistic post-marketing surveillance program for orthopedic devices. The objectives of ORTHOWATCH are: 1) to implement a standardized screening protocol for categorizing explanted prostheses; 2) to apply existing measurement technologies for quantitative assessment of explanted prostheses; and 3) to pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of CpG island RNAs and Polycomb-RNA interactions in developmental gene regulation' (CHROMATINRNA) targeting Seventh Framework.

assistant: **Abstract**

A great challenge in developmental biology research has been to understand how cell type specific expression programs are orchestrated through regulated access to chromatin. The interaction between non-coding RNAs and chromatin regulators is emerging as an exciting new research area with the potential to explain how chromatin modifications are targeted.Polycomb repressive complex 2 (PRC2) modifies chromatin to maintain developmental regulator genes specific for other cell types in a repressed state and is essential for embryogenesis across Metazoa. We have recently determined that CpG islands targeted by PRC2 generate a class of short non-coding RNAs. The RNAs are produced independently from mRNA, indicative of hitherto uncharacterised transcriptional processes.  Furthermore, we have found that the PRC2 subunit Suz12 is an RNA binding protein and directly interacts with these short RNAs and with other RNAs in cells. The role of ncRNA in targeting PRC2 to CpG islands and the importance of PRC2 RNA binding activity for development remains to be understood. Our aims are to:1. Determine the functional properties of CpG-island RNAs by A. identifying their conserved features, B. determining their role in polycomb targeting of CpG islands and C. investigating whether such a role relates to the antagonism of polycomb targeting by DNA methylation.2. Establish the biological role for Suz12 RNA binding activity by A. determining the structural determinants for Suz12 binding in vitro, B. verifying these features play a role in PRC2 RNA binding in cells and C. determining the role for PRC2-RNA interactions for polycomb function and development.This work promises to characterise a potentially fundamental aspect of cell biology and will open a number of avenues for understanding the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Ecological, molecular, and evolutionary spatial dynamics'.

assistant: **Innovation**

The study of wild populations will benefit of increasing integration of ecological, molecular, genetic, and evolutionary approaches. The Glanville fritillary butterfly has a classic metapopulation in a network of 4,000 habitat patches in the Åland Islands, Finland, within an area of 50 by 70 km, across which population surveys have been conducted since 1993. Taking advantage of the opportunity to sample a few larvae from full-sib groups of gregarious larvae in hundreds of local populations, this project involves large-scale phenotyping and genotyping of individuals across the large metapopulation. The aim is to advance our general understanding of the genetic basis of variation in individual performance and life-time reproductive success (fitness), and the role of ongoing natural selection in population dynamics of species living in fragmented landscapes. For genotyping, we select ~1,000 SNPs from annotated genes in the recently sequenced transcriptome of this species. The same SNPs will be used to construct a pedigree for the entire metapopulation for 4 years. Two broad questions will be addressed:   (1) Genetic basis of variation in dispersal, related life-history traits, and life-time reproductive success. This will be studied with association analyses, correlating individual phenotypes and genotypes to identify molecular variation with consequences for individual performance and fitness; and with pedigree analyses of natural populations, relating life-time reproductive success of individual larval groups to their phenotypic and genotypic composition.   (2) Spatio-temporal population dynamics, the role of ongoing natural selection and consequences for regional adaptation. The purpose is to investigate the causes and consequences of spatio-temporal variation in popula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fundamental and Applied Science on Molecular Redox-Catalysts of Energy Relevance in Metal-Organic Frameworks' to be submitted under Horizon 2020.

assistant: **Abstract**

Organometallic redox-catalysts of energy relevance, i.e. water and hydrogen oxidation, and proton and carbon dioxide reduction catalysts, will be incorporated into metal-organic frameworks (MOFs). Immobilization and spatial organization of the molecular catalysts will stabilize their molecular integrity and ensure longevity and recyclability of the resulting MOFcats. The organized environment provided by the MOF will enable the control of conformational flexibility, diffusion, charge transport, and higher coordination sphere effects that play crucial roles in enzymes, but cannot be addressed in homogenous solution and are thus largely unexplored. The effect that the MOF environment has on catalysis will be directly probed electrochemically in MOFcats that are immobilized or grown on electrode surfaces. In combination with spectroscopic techniques in spectroelectrochemical cells, intermediates in the catalytic cycles will be detected and characterized. Kinetic information of the individual steps in the catalytic cycles will be obtained in MOFs that contain both a molecular photosensitizer (PS) and a molecular catalyst (PS-MOFcats). The envisaged systems will allow light-induced electron transfer processes to generate reduced or oxidized catalyst states the reactivity of which will be studied with high time resolution by transient UV/Vis and IR spectroscopy. The acquired fundamental mechanistic knowledge is far beyond the current state-of-the-art in MOF chemistry and catalysis, and will be used to prepare MOFcat-based electrodes that function at highest possible rates and lowest overpotentials. PS-MOFcats will be grown on flat semiconductor surfaces, and explored as a novel concept to photoanode and -cathode designs for dye-sensitized solar fuel devices (DSSFDs). The desi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Telomere dysfunction and aneuploidy' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

The major hallmarks of almost all cancers are aneuploidy, deregulation of the cell cycle and the reactivation of telomerase. While telomerase expression as been widely shown to ensure chromosomal stability, telomere dysfunction can be made responsible for a neuploidies universally found in cancers. Aneuploidy develops early in tumour development while telomere dysfunction is mostly found at the end of cellular life span and might induce aneuploidy directly when checkpoint functions at the end of the life span a re abrogated. This proposal addresses how the last cell cycle transitions are monitored by the cell cycle checkpoints and how loss over control of these may lead to aneuploidy.We are proposing to study the DNA damage response in normal cells that have one or more short telomeres at replicative senescence and to elucidate whether different threshold levels trigger different responses. Furthermore we propose to study the chromosomal changes in cells that have abrogated checkpoints at replicative senescence and analyse if a common tetraploidy intermediate promotes the elimination of genes that suppress cell growth and amplifies those that are associated with growth advantage, including telomerase. Our major goal is to better understand the relationship between short telomeres and the induction of genomic instability that leads to carcinogenesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A CANcer Development mOnitor' under Seventh Framework.

assistant: **Concept**

Through further development, integration and validation of micro-nano-bio and biophotonics systems from previous projects CanDo will develop an instrument that will permit the identification and concentration determination of rare cells in peripheral blood for two key societal challenges, early and low cost anti-cancer drug efficacy determination and cancer diagnosis/monitoring.A cellular link between the primary malignant tumor and the peripheral metastases, responsible for 90% of cancer-related deaths, has been established in the form of circulating tumor cells (CTCs) in peripheral blood. Furthermore the relatively short survival time of CTCs in peripheral blood means that their detection is indicative of tumor progression thereby providing in addition to a prognostic value an evaluation of therapeutic efficacy and early recognition of tumor progression in theranostics. In cancer patients however blood concentrations are very low (=1 CTC/1E9 cells) and current detection strategies are too insensitive, limiting use to prognosis of only those with advanced metastatic cancer. Similarly problems occur in therapeutics with anti-cancer drug development leading to lengthy and costly trials often preventing access to market. There is therefore a clear need for a novel analytical platform capable of highly reproducible and reliable identification of CTC concentrations of interest in an easily accessible format.With all relevant industrial stakeholders and users onboard CanDo is uniquely capable of delivering such a platform. Its novel cell separation/SERS analysis technologies plus nucleic acid based molecular characterization will provide an accurate CTC count with high throughput and high yield meeting both key societal challenges. Being beyond the state of art it will lead
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Turkey's universities, SMEs and science centers' integration to Europe' (TUSMES).

assistant: **Innovation**

It is indispensable to have an innovation policy specifically targeting to the SMEs in order to realize the economic policy objectives of the European Union especially the aim to have a knowledge-based society by the year 2010 provided that SMEs are infl uential in job creation and research and development activities. As a candidate country, Turkey is particularly important with its large population and with its potential to innovate through 196.793 SMEs. Although the Turkish SMEs have the potential to i nnovate, they are not efficient in research and development activities and there is lack of cooperation between SMEs, universities and research and science centres. The proposed project aims to increase awareness and knowledge of the SMEs regarding Sixth Framework Programme and to assist them to improve their research and development capabilities by organizing training courses and workshops in different cities of Turkey with the participation of experts. These courses will be open to the participants from Turkey and CEEC and target to reach total 1820 experts; 1360 from SMEs and 460 from universities. Moreover, the consortium will assist SMEs in Turkey to find partners from the different member states, encourage them to involve ongoing projects under the FP6 by a competition; provide consultancy services on bureaucratic procedures and preparing EU contracts at every step; help them in technical issues such as preparation of proposals accessing scientific knowledge by establishing the links between SMEs - Research&Science Centers, SMEs - Universities, SMEs - Business Circles. The end result targeted is to make a meaningful contribution to the creation European Research Area by realizing inclusion of SMEs especially from Turkey. As a result of the co operation of Turkish
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'MATIC: Materiality of Imperial Crossings during the age of steam (c. 1850-1950)' (MATIC) targeting Horizon Europe.

assistant: **Abstract**

The MATIC (Materiality of Imperial Crossings during the age of steam, c. 1850-1950) project aims to deepen our understanding of modern colonial empires by exploring the material culture of maritime crossings within the British and French colonial empires during the age of steam (c. 1850-1950). This project focuses on the personal belongings of steamship travelers to explore the trade of items relevant to journeys at sea, the lived experiences of imperial maritime crossings, the ‘colonial situations’ that arose on board ships, as well as the material circulations that empires facilitated. Bridging colonial history, material culture studies, and maritime history, MATIC will go beyond the state of the art by demonstrating that materiality was a crucial dimension of imperial ‘lives in transit’, whose study illuminates the social, cultural, and political ramifications of imperial mobility, and fosters new insights into the role of materiality in the imperial archive. This project further sheds new light on how actors largely absent from written sources – colonized passengers, women, and children – intimately experienced colonial empires. To accurately capture this global and intimate history, MATIC employs an innovative and interdisciplinary methodology, integrating quantitative methods as well as theoretical perspectives from material and visual culture studies, gender studies, oral history, new mobility studies, and sociology. In addition to printed sources, it draws on a variety of archival materials from numerous repositories in England and France, surviving artefacts from museum collections, and oral history interviews. This project will significantly enhance the ER’s professional experience by further diversifying his research methodologies, enhancing his ability to wo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Observing Binaries in Transition Discs' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Star formation begins when the densest regions in molecular clouds collapse under their own weight forming so called “young stellar objects” (YSOs), i.e. protostars surrounded by a gas+dust disc (known as “protostellar” or “protoplanetary” disc), expected to be the birth place of planets in this newly formed proto-exo-solar systems.  The advancements during the past decade in our observational capabilities revealed that 10% of the observed protostellar discs in YSOs present large (~10 –100 au) dust and gas depleted cavities surrounding their protostars, as well as a number of spectacular features such as spirals, shadows and other non-axisymmetric over-densities. Discs with cavities have been historically referred to as “transition discs” and are among the brightest and most studied YSOs in close star forming regions. The presence of a massive planet (several Jupiter masses) interacting with the disc has been shown to be an effective mechanism for forming dust/gas cavities and the observed structures. The possibility that binary stars, i.e. much more massive and luminous than giant planets, could lie unresolved in the centre of transition disc cavities has been little explored, mainly because of the argument: “if they were present they should be visible”. However, both theory and observations hint that such binaries could be much harder to be detected than previously thought, supporting the idea that some transition discs could be in fact “circumbinary”. Shedding light on this issue represents the heart of the “Observing Binaries in Transition-Discs” (ORBIT-D) project.  ORBIT-D has the ambitious goal of providing an ultimate answer to the question “Which transition discs are circumbinary discs surrounding undetected binaries?”. Identifying circumbinary discs in the tran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Observing structural dynamics at surfaces with Ultrafast Low-Energy Electron Diffraction' (ULEED) targeting Horizon 2020.

assistant: **Abstract**

This grant application proposes the establishment of Ultrafast Low-Energy Electron Diffraction (ULEED) as a novel and versatile approach to investigate ultrafast structural dynamics at surfaces and in ultrathin films. Two-dimensional systems such as surfaces and molecular monolayers exhibit a multitude of intriguing phases and complex transitions. Studying the ultrafast dynamics of these materials elucidates correlations and microscopic couplings, but the access to structural degrees of freedom with ultrahigh time resolution remains challenging. Low-Energy Electron Diffraction (LEED) is a powerful technique in surface science to determine the atomic-scale structure and symmetry of surfaces. However, time-resolved LEED has proven exceedingly difficult to realize, owing to the problems in realizing suitable low-energy electron pulses of sufficiently short pulse duration and high beam quality.This project targets both of these present limitations by using laser-triggered nanoscopic electron sources to generate high-brightness beams of low-energy electrons. Specifically, nanotip cathodes driven by nonlinear photoemission will be integrated in compact micro- and nanofabricated electrostatic lens assemblies. This will allow for a drastic reduction of electron beam propagation distances while maintaining a high level of beam control and focusing ability. Using this electron source, we plan to develop a laser-pump/electron-diffraction-probe setup at low electron energies with a temporal resolution of few hundred femtoseconds and less. A number of strategies will be followed to improve the temporal resolution of the setup, including wavelength-tuning of the laser excitation and active spectral compression of the electron pulses using locally enhanced THz fields. We will apply UL