RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'EcoDesign Interactive Systems (ECODIS)'.

assistant: **Concept**

Because of their large companies and/or customers' pressure to comply with the new regulatory framework, around 10,000 European SMEs operating in the field of electric, electronic and/or automotive industries have to face increasing information work on their supplies environmental characteristics, which they are totally unprepared and not instrumented for.To avoid European SMEs to suffer from a zero value added reporting work as well from customers topdown environmental and/or industrial choices, ECODIS will offer them to take advantage of this new policy context.In fact through ECODIS, SMEs will have a genuine opportunity to develop their own product environmental strategy and to ecodesign their products in a life cycle/supply chain approach. Through ECODIS, SMEs will be provided an innovative ecodesign tool:1. Adequate supporting tools such as decision aid systems,2. Appropriate methodology: POEMS, Product Oriented Environmental Management Systems.ECODIS leading lAGs, FP A (EDIT* program) and FIEEC (EIME* tool) have collaborated with major leading companies producing automotive equipment 5FP A) and electric/electronic appliances (FIEEC) to develop ecodesign tools since 1999.Within ECODIS in collaboration with the others lAGs, FP A and FIEEC have decided:1. to exploit the synergies of existing systems: total past investment around 4,000,000 e,2. to adapt these existing ecodesign systems to current SMEs' needs and capabilities,3. to complement these systems in elaborating missing" elements,4. to share results between lAGs operating on similar and complementary sectors,5. to train SMEs' management and technical staff,6. to disseminate ECODIS results to the largest European SMEs community and to other industries.7. To this end, ECODIS has built a consortium around major E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'The role of nuclear architectural RNAs in the long-term maintenance of the neural epigenome'.

assistant: **Innovation**

Neurons in the brain must function for a life-time with limited replacement; thus, they need to robustly maintain their identity and function. Understanding the mechanisms underlying the longevity and persistence of neurons will be key for preventing and treating age-related neurological diseases. By focusing on epigenetic mechanisms regulated by nuclear RNAs, the project aims at understanding the fundamental mechanisms underlying the long-term maintenance of neural identity and their biological roles in the development of age-related vulnerability. The successful completion of this proposal will uncover novel roles of RNAs in long-term epigenetic regulation, and key biological links between epigenetic dysregulation and age-related pathological development.We recently discovered that some nuclear RNAs in rodent brains do not turn over for two years. These RNAs are maintained in a neural cell type-specific manner and are mainly localized around heterochromatin. Through a targeted approach, satellite RNA was found to be one of the stable nuclear RNAs and is critical for the maintenance of heterochromatin. Based on this finding, the proposed project aims to test the specific hypothesis that neural cells possess several long-retained nuclear RNAs which interact with chromatin to stabilize cell type-specific epigenetic regulation, but that they deteriorate as a result of aging. To address this question, we will use an interdisciplinary approach. First, the molecular identity of long-retained nuclear RNAs will be probed globally using deep sequencing. In parallel, mechanisms responsible for maintaining RNAs will be investigated Second, the roles of the nuclear RNAs and associated complexes we identify in maintaining cell type-specific epigenetic regulation will be investigate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Monolithic Multi-Junction Picosecond Avalanche Detector for future physics experiments and applications' (MONOLITH) under Horizon 2020.

assistant: **Objectives**

Particle-physics, space research and several other fields of basic and applied science necessitate the production of thin sensors capable to provide excellent position and time resolution at the same time.The diode structure of present silicon pixel sensors strongly penalises the enormous potential of silicon-based time measurement: the ~30 ps intrinsic limit of diodes was already reached in sensors with internal gain with pad sizes of 1 mm2. Therefore, new ideas are needed to improve by another order of magnitude and reach the picosecond level.This project introduces a novel silicon-sensor structure devised to overcome the intrinsic limits of present sensors and simultaneously provide picosecond timing and high spatial resolution in a monolithic implementation. This goal is achieved by the introduction of a fully depleted multi-junction. The remarkable performance of this new sensor, combined with the simplified assembly process and reduced production cost offered by the monolithic implementation in standard CMOS processes, represent the required breakthrough.In addition to the novel multi-junction sensor, the cornerstones of the project are the low-noise very-fast SiGe HBT frontend and the patented TDC with robust synchronisation method that the PI has already produced in preliminary versions.The monolithic detector proposed here will offer a sustainable solution for the next generation of experiments at hadron colliders, in nuclear physics and for space-borne experiments in cosmic-ray physics and solar physics. Besides the primary goal of basic science, it will represent an extraordinary enabling technology for the large spectrum of high-tech applications that benefits of picosecond-level Time-Of-Flight measurements. The innovative monolithic detector introduced here
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Composition of government expenditure and economic growth'.

assistant: **Objectives**

Most studies on growth emphasize that increasing human capital is critical for explaining economic growth. There is a wide consensus that education plays a key role in creating human capital, and since the government is responsible for the majority of investments in education, one can relate the accumulation of human capital to government spending.At the same time, given the limited amount of resources available to the government, many countries face important tradeoffs between education and investment in infrastructures. The aim of this research is twofold. First, we develop a model of economic growth to explore the possibility that government expenditure can enhance economic productivity in two alternative ways: raising the productivity of physical capital or by raising the productivity of human capital. An essential feature of our analysis is the introduction of government spending in the process of human capital accumulation, which is widely accepted but generally ignored. Second, we estimate the theoretical model developed in stage one.The goal is to get an estimate for the returns on public and human capital, thus helping governments evaluate the impact of their policies. The issues raised by this research are central not only to the European debate of real convergence, but also to the debate on how to classify public investment in the context of the Stability and Growth Pact (SGP). In the first case, the European structural funds aim at co-financing a series of government programs concerning not only in vestment in infrastructures, but also human capital. In the second case there is the issue of the deficit constraints specified in the SGP. Therefore, it is relevant to provide a qualitative as well as a quantitative measure of the impact of both types of spending
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mitochondrial Fission 1 protein Interactions: from discovery to Acute myeloid leukemia pathophysiology and Therapy' under Horizon Europe.

assistant: **Concept**

Mitochondrial morphology is controlled by a set of “mitochondria-shaping” proteins that govern fusion and fission of the organelle. Fission is executed by dynamin-related protein 1 (DRP1) that binds to adaptors on the outer mitochondrial membrane to oligomerize and sever mitochondria. Fission 1 (FIS1) is among the putative mammalian DRP1 adaptors, but it appears dispensable for mitochondrial fission. Conversely, FIS1 seems to participate in the regulation of mitochondrial autophagy (mitophagy), interaction between mitochondria and lysosomes, and apoptosis. Because of these multifunctional roles, FIS1 emerged as an appealing pharmacological target and peptides inhibiting its interaction with DRP1 have been advanced in the experimental treatment of ischemia-reperfusion and of genetic conditions such as Huntington’s disease. More recently, FIS1 was identified as a crucial factor to sustain Leukemia Stem Cells (LSCs) in Acute myeloid leukemia (AML), the second most prevalent and the most fatal leukemia in adult patients. However, our scarce knowledge of the biology of Fis1 is mirrored by the uncertainties on how FIS1 regulates AML LSCs. To close this gap in knowledge, I will take a chemical biology approach and design innovative genetically encoded sensors for FIS1 functions that I will use to identify potential FIS1 small molecules inhibitors. I will then use these chemical probes to evaluate which cellular function of FIS1 is essential for maintenance of AML LSCs. Overall, this project will unveil how a multipronged mitochondrial protein regulates cell pathophysiology and will deliver novel chemical tools to investigate FIS1 function in the context of AML and potentially to evolve into therapies for this hitherto poorly treatable cancer.


**Keywords:** mitochondria, dyna
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evolutionary Protistology conference will bring together scientists and students interested in molecular & cell biology, systematic, and evolution of unicellular organisms' (1998-2002).

assistant: **Concept**

The International Society of Protistology (ISEP) is a group comprised of approximately 400 scientists & students from around the world. In the year 2000 the ISEP will convene in Ceske Budejovice for its thirteenth biannual conference (ISEP-13). The aim of the ISEP-13 conference is to bring together leading scientists & many graduate students from various fields of current biology (molecular biology, evolution, parasitology, botany, protozoology) that are interested in the study of unicellular organisms-protists. The protists not only represent the most ancient & diverse group of eukaryotes, but also include numerous free-living species that are present in all environments as well as members, which are important parasites of plants, & animals including humans. In the last few years several important discoveries made by studying protists (RNA editing, trans-splicing, genome rearrangements, ribozymes, organellar transport, changes of the surface antigen) have had a major influence on progress in the field of molecular & cellular biology.Therefore, protists are becoming important model organisms in modern biology. The program of the conference will be focused on recent trends in evolutionary protistology,the most significant being phylogenetic analyses based on ribosomal RNA & conserved protein sequences, the nature of the apicoplast & other newly described DNA-containing organelles, the evolution of mitochondrion & hydrogenosome, genome rearrangements, evolution of RNA editing & kinetoplast DNA, & protistan models of basic cell functions, such as motility, cell division & protein posttranslational modifications. The previous twelve conferences of the ISEP have shown that the interdisciplinary approach is fostered by such meetings & that great advances in our collective und
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Smartphone Thermal ANalysis for Diabetic foot Ulcer Prevention and treatment' (STANDUP), addressing dissemination and exploitation.

assistant: **Impact**

Diabetic foot (DF) disease includes neuropathy, peripheral arterial disease and infection which may lead to ulceration and subsequent lower limb amputation. DF ulcers could be further reduced according to diabetes experts. Temperature is one of the possible clinical parameter which is not currently well exploited. Recently, smartphones can acquire thermal images thanks to dedicated thermal camera. The STANDUP project proposes a smartphone based system such that mobile, accurate, friendly, low cost and fast thermal analysis of the plantar foot surface can be achieved. The smartphone thermal imaging system will be composed of a smartphone and of a FlirOne thermal camera. In the STANDUP project, two smartphone applications will be developed. The first one (A1: hyperthermia detection and analysis of thermal variations in time) will permit to detect possible hyperthermia of the plantar foot surface and will analyze temperature variations on targeted regions of interest. The second smartphone application will assess temperature, color, and 3D shape of DF ulcer along time. These smartphone applications will be evaluated during clinical trials in hospitals. In the first clinical trial, a cold stress test will permit to detect neuropathy and peripheral arterial disease. In the second clinical trial, temperature, color, and 3D shape in DF ulcers will be studied during its treatment. The third clinical study will assess the effectiveness of new insoles, these new insole will be developed during STANDUP with the objective to relive hyperthermia in DF. These 2 smartphone applications will be enhanced to result in an advanced prototype of smartphone based system for the targeted medical applications. This advanced smartphone thermal prototype, and the new insoles, will be developed d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Secure Execution of Smart Contracts' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Smart contracts are computer programs that autonomously execute on the blockchain. They have the potential to revolutionize many applications from finance, insurance, energy, healthcare, and production industries. However, smart contracts have become an appealing attack target. Since smart contracts are always online and easy to hack once a vulnerability is discovered, recent attacks resulted in large losses of cryptocurrency thereby questioning the benefits of this revolutionary technology. CONSEC is the first holistic framework that will enable secure execution of smart contracts on the blockchain. It takes a holistic approach by developing security mechanisms covering various stages of the blockchain ecosystem starting from smart contract development and maintenance to smart contract execution and forensic analysis. A key aspect of this project is the development of the first secure smart contract compiler which detects and automatically patches smart contract bugs in the development phase. An innovative update process complements the secure compiler to mitigate new and unknown attack vectors supporting developers who deployed vulnerable contracts. Further, CONSEC will develop a secure execution monitor to audit smart contracts while they execute on the blockchain allowing instant reaction to run-time attacks. To tackle the current lack of comprehensive approaches to validate the security of already deployed contracts, CONSEC will develop new forensic dynamic analysis approaches. CONSEC establishes trust in smart contract technology enabling secure deployment and execution of smart contracts on the blockchain.


**Keywords:** smart contracts, blockchain, program-flow security, run-time monitoring, fuzzing, forensic analysis, secure compilers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Lanthanide Dendrimer-Polymer Hybrids' in the context of a Seventh Framework call.

assistant: **Objectives**

Organic complexes of lanthanides are enjoying a renaissance due to their increased commercial usage (eg. in lighting/display devices, as MRI contrast agents, as luminescent markers for bioassay). However, considerable challenges remain to overcome the low absorbance of Ln(III) cations and limited luminescent performance of emitters in the Near-Infra Red (NIR).This project will characterise lanthanide chelates with unique topologies provided by dendrimers and 'star-shaped' polymer materials, which allow for the incorporation of multiple sensitizing chromophores and shield the luminescent metal from deactivation by its immediate environment. These compounds will have improved luminescent performance at wavelengths desired for biological assays and biomedical imaging.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Advanced Eco-designed Fibres and Films for large consumer products from biobased polyamides and polyesters in a circular EConomy perspecTIVE'.

assistant: **Innovation**

The EFFECTIVE project intends to demonstrate first of its kind and economically viable routes for the production of biobased polyamides and polyesters from sustainable renewable feedstock for the obtaining of fibres and films with enhanced properties, market competitiveness and increased sustainability. Such materials will be applied into eco-designed large consumer products targeting different markets, i.e. construction, automotive, primary and secondary packaging and textile and with the potential of being applied into many other markets (fishing, engineering plastics, agriculture, hygiene and personal care).Following a circular economy approach, the sustainability of the value chains will be further enhanced by the demonstration of an improved end-of-life of the developed eco-designed biobased solutions through the application of monomer regeneration, recycling (for polyamides based fibres and films) and composting/anaerobic digestion (for polyesters based films) processes. The idea that “the end is a new beginning” will indeed drive the products design and realization.The project covers the whole value chain: feedstock production, conversion into innovative biobased building blocks through biotechnological and chemical processes, formulation of innovative biobased polymers (polyesters and polyamides), final products development, end-of-life products management and processing.The project intends to represent a key milestone towards the future industrialization of biobased fibres and films production in Europe foreseeing the mobilization of relevant investments by involved industry partners and fostering the adoption of multi-stakeholders collaboration models to demonstrate effective ways to develop new cases of biobased economy interconnected with circular regenerati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European solar magnetism network' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Solar magnetism is one of the great challenges of astrophysics. The intricate structure of the solar magnetic field exemplifies cosmic magnetic fields; its dynamical modulation affects the human environment.The European Solar Magnetism Network exploits advanced European technology--- five solar telescopes at the Canary Islands and ESA's SOHO mission in space--- to gain understanding of the roots of solar magnetism.The Network will study the structure and dynamics of solar surface fields, the topology and evolution of solar active regions, and the electro dynamical coupling between the solar interior, photosphere, and outer atmosphere by perfecting solar magnetometry, organizing joint multi-telescope observing campaigns, and analyzing the results through numerical inversions and simulations.