RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The model plant system Trithuria (Hydatellaceae), a new window into the origin of flowering plants and gene function' under Seventh Framework.

assistant: **Concept**

Flowering plants are important because they underpin much of planetary ecology, priming the food chains that power terrestrial ecosystems, and providing us with most of our material needs (oxygen, food, fuel, pharmaceuticals, etc). The study of a few highly specialized model plants (such as Arabidopsis) has been a particularly powerful paradigm for understanding the functional biology of plants. These studies are currently being integrated with large-scale DNA sequencing studies of diverse plant genomes, allowing plant biologists to unravel patterns of gene diversification (= phylogenetics), and facilitating predictive studies of gene function in a comparative biological framework (= phylogenomics). Functional plant biologists have focused the bulk of their attention on the monocots and eudicots, the two largest groups of flowering plants. Until now we have lacked an early evolving angiosperm to provide a meaningful point of comparison for phylogenomic studies of existing model plant systems, and of the crop plants that underpin much of the European agroeconomy. Trithuria submersa in the family Hydatellaceae is being developed as a new model system to fill this important gap. I propose to develop large-scale phylogenetic data sets from genomic data that have been generated for this family. I will use this to resolve the branching order of the first flowering plants, which include Hydatellaceae. This will address a major conundrum in plant biology that has been unresolved since the time of Charles Darwin. I will also explore how these data sets can be used as a tool to better predict gene function and orthology (relatedness) in other major groups of flowering plants. Finally, I will resolve a key problem in the species biology of Trithuria submersa concerning its genetic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multi-level governance of natural resources: Tools and processes for water and biodiversity governance in Europe' (GOVERNAT) under Sixth Framework.

assistant: **Objectives**

The overall objective of GoverNat is to enable decision makers to better handle questions of multi-level environmental governance in an enlarged EU. Therefore it brings together a unique network of research institutes with SMEs, administrations and NGOs dealing with environmental governance. The partners jointly mentor the fellows, safeguard the practical relevance of their research, and ensure the appropriateness of the results and of their presentation for scientists and non-scientists outside the consortium. Theoretical and empirical elements of research will dynamically build on each other. GoverNat will systematically analyse multi-level water and biodiversity governance (such as the implementation of Water Framework Directive and Natura 2000) in several European countries in order to allow for generalisations for the governance of natural resources. We will test the methodical hypothesis that a combined use of analytical decision tools and participatory processes is particularly useful for improving multi-level environmental governance. Therefore, we evaluate the instrumental, normative, and substantive roles of participation and of analytical decision tools in decision processes. We then develop appropriate contextualisation of participatory and analytical processes in case studies and evaluate them. This contextualisation helps bridging the science/policy and public/policy gaps in multi-level environmental governance. The central training objective is to give scientists an in-depth scientific and practical training in the main aspects of European environmental governance: understanding of political processes, actors and arenas, institutional settings with their associated transaction costs, European and national legal regulations, philosophical reflections on le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Optimization of Process Prameters of the Automatic Pressure Gelation Process for the Production of High Quality Electrically Insulating Parts of Duroplastic Cast Resin Moulds'.

assistant: **Concept**

In the automatic pressure gelation process high quality electrically insulating parts of duromeres are produced by injection under pressure into heated moulds. During this process, material damages (electrical and mechanical weak points) may be caused to the product by exothermic overheating due to chemical reactions. To avoid such defects, a calculation program is to be worked out for simulating the design of component, mould and casting process. Such a program will allow the component and mould condition as well as the control of the mold filling process to be optimized. Additionally, critical temperature distribution, unintentional gelation front evolution and undue internal mechanical tension gradients should be avoided. The objective is to obtain through mathematical modelling with material property values and process parameters a basis to derive the premise for an optimum design and fabrication of products together with the appropriate production technique.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Exploiting light coherence in photoacoustic imaging'.

assistant: **Objectives**

Photoacoustic imaging is an emerging multi-wave imaging modality that couples light excitation to acoustic detection, via the photoacoustic effect (sound generation via light absorption). Photoacoustic imaging provides images of optical absorption (as opposed to optical scattering). In addition, as photoacoustic imaging relies on detecting ultrasound waves that are very weakly scattered in biological tissue, it provides acoustic-resolution images of optical absorption non-invasively at large depths (up to several cm), where purely optical techniques have a poor resolution because of multiple scattering. As for conventional purely optical approaches, optical-resolution photoacoustic microscopy can also be performed non-invasively for shallow depth (< 1 mm), or invasively at depth by endoscopic approaches.  However, photoacoustic imaging suffers several limitations. For imaging at greater depths, non-invasive photoacoustic imaging in the acoustic-resolution regime is limited by a depth-to-resolution ratio of about 100, because ultrasound attenuation increases with frequency. Optical-resolution photoacoustic endoscopy has very recently been introduced as a complementary approach, but is currently limited in terms of resolution (> 6 µm) and footprint (diameter > 2 mm).The overall objective of COHERENCE is to break the above limitations and reach diffraction-limited optical-resolution photoacoustic imaging at depth in tissue in vivo. To do so, the core concept of COHERENCE is to use and manipulate coherent light in photoacoustic imaging. Specifically, COHERENCE will develop novel methods based on speckle illumination, wavefront shaping and super-resolution imaging. COHERENCE will result in two prototypes for tissue imaging, an optical-resolution photoacoustic endoscope for m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Einbindung von abfallstoffen bei der produktion baukeramischer artikel.', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Für die Herstellung von Baukeramik werden nach derzeitigem Stand der Technik neben dem Hauptrohstoff Ton verschiedene andere Rohstoffe verwandt, um entsprechende Versalzeigenschaften zu erreichen. Diese müssen vor allem die hohe Brenntemperatur aushalten können. Bisher können deshalb Abfallstoffe in der keramischen Industrie nur in einem sehr geringen Umfang als Rohstoffe wiederverwendet werden. Hindernis sind die hohen Brenntemperaturen und die damit verbundenen Anforderungen, die an das in den Masseversatz eingebrachte Material gestellt werden müssen. Ziel des Vorhabens ist, dass Brennverfahren so abzuwandeln, dass auch Abfallprodukte als Kompensation für die Rohstoffe in den Masseversatz eingebracht werden können. Hierzu ist es notwendig, das Brennverfahren so zu modifizieren, dass die Brenntemperatur gesenkt werden kann und eine Verwertung von Abfallprodukten möglich wird.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Unleashing Integrated Sensing and Communication Pontentials by Exploiting Shared Scatterers in Millimeter-Wave Systems'.

assistant: **Innovation**

In the next-generation millimeter-Wave (mm-Wave) networks, sensing is assumed a vital role in various applications, including transport systems, smart cities, and public safety. Integrated sensing and communication (ISAC) is identified as a key technology to achieve ubiquitous sensing with communication systems, where the convergence of sensing and communication functionalities on shared hardware holds the promise of reduced costs, enhanced spectral and energy efficiency, and reduced latency. Before incorporating ISAC into next-generation communication standards, however, the sensing and communication capacities of ISAC should be further improved. The 2-year MSAC Postdoctoral Fellowship, ISAC-SS, seeks to unlock the full potential of ISAC systems by exploiting the shared scatterers in communication and sensing channels. The state-of-the-art (SoA) in ISAC signal processing has largely overlooked this critical element, leaving room for performance improvement. Research Objectives (ROs) are as follows: RO1: Establish fundamental performance limits for ISAC systems leveraging shared scatterers. RO2: Designing beamforming (BF) and signal reception algorithms that enhance ISAC performance by exploiting shared scatterers. RO3: Conduct hardware experiments and create a dataset with diverse shared scatterer configurations for model and algorithm verification. By addressing these ROs, ISAC-SS aims to propel the field of ISAC to new heights, ultimately improving the quality and reliability of infrastructure and contributing to safer transport systems. The collaboration between Tampere University (TAU) and Arizona State University (ASU) bolsters the vision of establishing an independent academic career dedicated to advancing ISAC technology of the researcher.


**Keywords:** mm-Wav
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Pqr2003'.

assistant: **Innovation**

Three major and interrelated subjects are in the background of the meetings: Poisson brackets were introduced to study the 3-body problem in celestial mechanics. Their study gained renewed interest in the second half of the twentieth century and Poisson geometry is now an active field of research, stimulated by its connections with harmonic analysis on Lie groups, quantum physics (in particular deformation quantisation), holonomy and integrated systems.The passage from one level of physical theory to another can often be achieved using the mathematical notion of deformation, in a properly chosen category. Application of this idea to the passage from classical to quantum mechanics lead Flato, Lichnerowicz and Sternheimer in 1976 to create a new domain called Deformation Quantisation.Symmetries have played a major role in the developments of mathematics and physics in the 20th century and lead to the very wide subject of group representations. Spectacular recent developments have occurred in the last years in those three areas and their interplay. For instance, let us mention the proofs of existence and classification for deformation quantisation on general Poisson manifolds, based on the formality theorem, given by Kontsevich in 1997 using graphs and by Tamarkin and him using operands in 1999, which gave rise to a wide array of new results and the extension to algebraic varieties; new geometric constructions of representations of non-compact reductive Lie groups with new character formulas by Kashiwara, Schmid and Vilonen; the development of groupoids and algebroids by Moerdijk, Weinstein and others as a formalism to express very general theories.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Determination of specific components from “stromal PDAC signature” involved in PDAC Associated Neural Remodeling (PANR) and their use as clinical tool-box.' to be submitted under Seventh Framework.

assistant: **Abstract**

Pancreatic ductal adenocarcinoma (PDAC) is the most intractable of human malignancies. Survival rate at 5 years is very low (less than 5%). Patients are most of the time diagnosed while the disease has already spread out and benefits from surgical resection is often cut off due to local recurrence and lack of efficient chemotherapy. Indeed, it is urgent to develop new tools to be used by clinicians in order to propose better management of the disease. This project is based on two specific characteristics of PDAC. First, the existence of a prominent tumor stroma compartment (desmoplasia) consisting of non-neoplastic myofibroblastic pancreatic stellate cells, vascular, nerve and immune cells surrounded by immense quantities of ECM, from far exceeding that found in most other tumor types. Second, the very specific and almost unique PDAC associated neural compartment remodeling (PANR) correlated with the intense neuropathic pain observed in this disease. PANR consists in a modification of nerve fiber structure/density and presence of tumoral cell within nerve fibers, a phenomenon called peri-neural invasion which is highly correlated to local recurrence of primary PDAC tumor. We and others hypothesized that, by dialoguing with cancer cells, non-tumoral stromal cells impact on PDAC tumor biology by modeling the own tumoral structure and fostering the tumor development. Regarding this concept we suppose that the intra-tumoral micro-environment has an active and efficient role on the neural compartment remodeling, its associated pain and local recurrence. By integrating preliminary and ongoing results from transcriptomic and proteomic analysis of human PDAC and endogenous mice model developing PDAC, as well as multiples cell lines co-culture studies, we aim to determine this “
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Toxicokinetics and biotransformation in aquatic invertebrates' (TOXKINBIO).

assistant: **Concept**

Pesticides, pharmaceuticals and other chemicals support our modern standard of life, but their use can have detrimental impacts on our environment. We want to study the uptake, biotransformation and elimination (toxicokinetics) of pharmaceuticals in aquatic invertebrates. We aim to identify and model biotransformation pathways in four different species. Studying the comparative toxicokinetics of small, aquatic invertebrates is of great interest because it contributes to understanding evolutionary and environmental mechanisms and causes of differences in species sensitivity to chemicals.We want to apply a cutting edge analytical method to discover and quantify biotransformation products and pathways of pharmaceuticals (Ibuprofen, Fluoxetine, Carbamazepine, Venlafaxine) in small aquatic invertebrates (Daphnia magna, Chironomus riparius, Hyalella azteca, Lymnaea stagnalis).We selected pharmaceuticals which are frequently detected in aquatic systems, have known adverse effects on aquatic invertebrates and are metabolised in humans. Test organisms are cultured and were selected based on their importance in chemical testing (ecotoxicology) as well as their diversity in respiratory strategy and phylogeny.Extracts of exposed and control organisms are analysed using high resolution mass spectrometry complemented by expert systems for the prediction of transformation pathways and products. We will carry out toxicokinetic experiments where we measure concentrations of parent compound and biotransformation products in the organism at different times during the experiment. A pulsed exposure design ensures efficient measurement and calibration of the toxicokinetic model consisting of a set of differential equations. We hope to find novel biotransformation pathways and will search for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sustainable Bridges: Assessment for future traffic demands and longer lives (SUSTAINABLES BRIDGES)' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

Upgrading of the existing European railway bridges is needed to meet the demands for increased railway transportation capacity. The objectives of this project are to -Increase the transport capacity of existing bridges by allowing axle loads up to 33 tones for freight traffic at moderate speeds -Increase the capacity for passenger traffic with low axle loads by increasing the maximum speeds up to 350km/hour -Increase the residual lifetime of existing bridges with up to 25% -Enhance management, strengthening and repair systems The overall goal is to enable improved capacity without compromising the safety and economy of the working railway. Much previous research work has been carried out within the above areas. There is, however, a need for integration, innovative development and testing in order to establish efficient procedures for management and safe upgrading of railway bridges.The following work will be carried out: Map existing knowledge and bridge types (WP 1)·Investigate demands for interoperability between countries (WP2)·Develop new methods for condition assessment and inspection (WP 3)·Develop new methods to determine capacity and resistance. Investigate loads and load distributions (WP4)·Develop monitoring methods based on new technologies (WP 5)·Develop new repair and strengthening methods using e.g. carbon fibres (WP 6) Demonstrate new methods by field testing of existing and new bridges (WP 7-8)·Train bridge consultants and contractors in the use of the new methods (WP 9)The project will be carried out by a consortium of bridge owners, consultants, contractors universities and research institutes from all over Europe. Professor Ingvar Olofsson, Skanska, Sweden, will be coordinator and Professor Lennart Elfgren, Luleå University of Technology Sweden, will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Fucosylated Clusterin: a novel mechanism of tumor escape from immune response' (FUCTURE).

assistant: **Concept**

Clusterin (CLU) is a ubiquitous glycoprotein that function as an extracellular chaperone, binding to apoptotic cells and stressed-proteins and preventing the generation of insoluble aggregates. Although CLU is overexpressed in many type of cancers and associated with bad prognosis, the nature of this association remains obscure. It has been previously discovered an isoform of CLU present in seminal plasma that bears fucosylated glycans that confers the ability to bind to DC-SIGN; an endocytic C-type lectin receptor expressed on dendritic cells (DCs) and macrophages (MAC) that has been associated with immunosuppression. Our preliminary results showed spontaneous regression of tumors in CLU-/- mice after adoptive transfer in 2 models. We also observed that CLU present in breast cancer bears fucosylated glycans with the ability to bind to DC-SIGN. We hypothesize that tumor fucosylated CLU (Fuc-CLU) promotes immunosuppression by targeting tumor cell-associated antigens to DC-SIGN expressing DCs and MAC, promoting antigen presentation in a tolerogenic context. In this sense, Fuc-CLU could represent a new mechanism of tumor escape from immune response.  The main objectives are: to analyse Fuc-CLU expression pattern and production by tumor and stromal cells; to address the role of Fuc-CLU in immune modulation and tumor cell-associated antigen presentation; and to study the effect of Fuc-CLU on tumor development in an in-vivo model.The expertise of Dr. Amigorena and Institute Curie represent a major competitive advantage for the project. The results are expected to be published in peer-reviewed journals of high impact (with Open Access whenever possible), communicated in scientific meetings and to society at large. Expected results and deliverables will enhance the knowledge ba