RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Extending the Quality of Public Transport' to be submitted under Fourth Framework.

assistant: **Abstract**

The objective of the Extending the Quality of Public Transport (EQUIP) project was to develop a toolbox in the form of a Handbook for the self-assessment of internal quality performance by local passenger transport operators and to ensure, by means of awareness raising activities and liaison activities, that potential users are aware of its existence.The major, and most tangible, output of EQUIP has been a Handbook for the self-assessment of internal quality performance by land-based local public transport operators.  This Handbook has dealt with all aspects of the service as provided by the public transport operator as well as relevant aspects of transport system operation.  It has used the main indicators developed by the European Committee for Standardisation (CEN)1 as the starting point and covers all modes of local surface-based public transport (bus, trolley bus, tram/light rail, Metro and local heavy rail).  In this way EQUIP has provided an in-depth and mode based analysis (the 'vertical' dimension) in contrast to the 1998/99 Pilot benchmarking of local transport systems which worked at an urban transport systems level (the 'horizontal' dimension).Whilst the principal focus of the EQUIP project has been on the internal performance of the local public transport operator it must be remembered that service provision, or supply, will naturally be influenced by what is demanded by the consumer.  For local public transport there are two groups of consumers: the first group is the travelling public and the second is the procurers of local public transport on behalf of the travelling public (in most cases this is the local authority).  As a result, EQUIP has investigated which supply related indicators are relevant.TECHNICAL DESCRIPTION:Two key activities took place dur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Determining the mechanisms of lipid-targeting antibiotics in intact bacteria' under Horizon Europe.

assistant: **Concept**

Antimicrobial resistance is a major threat to global health. To combat this threat, new antibiotics with novel binding modes are urgently needed. Ideal candidates could be lipid-targeting antibiotics (LT-antibiotics) that target special lipids that only exist in bacterial, but not in human cell membranes. These drugs kill refractory pathogens without detectable resistance. This has generated huge interest.  So far, the molecular mechanisms of LT-antibiotics have proven elusive due to technical challenges: 1) structures of small drug?lipid complexes in membranes cannot be solved by traditional methods; 2) LT-antibiotics need to oligomerize to become active; and 3) binding modes are strongly affected by cell membrane profiles. In consequence, it has been impossible to visualize native binding modes and an entire class of potent antibiotics remains poorly understood.  In pioneering studies on the drug teixobactin, my lab recently presented the first quantitative insights into the mechanisms of LT-antibiotics in cell membranes. Strikingly, we discovered that teixobactin uses a novel ?double attack? type of antimicrobial action, in which teixobactin forms large oligomers that both block the peptidoglycan synthesis and damage bacterial membranes. These findings raise new questions about LT-antibiotics.  I propose to establish a comprehensive understanding of LT-antibiotics by elucidating their native binding modes in intact bacteria and at several length-scales (? to ?m). To this end, I will develop solid-state NMR methods, isotope-labelling strategies, and super-resolution microscopy setups. With these tools, I will elucidate the mechanisms of some of the most promising antibiotics of our time: 1) novel drugs from unculturable bacteria; and 2) daptomycin, a front-line drug w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Center of competence in integrated technical and quality systems for corrosion protection' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Centre CORPROT acts in the area of integrated technical and qualitative systems for corrosion protection. This means every offer to the market in terms of corrosion protection consists of material selection, coating, and quality control. Seven main packages are proposed: workshops, conferences, training for industry, missions and stays, promotion and dissemination and co-ordination package. Every thematic package concerns problems of integrated systems i.e. design, material, coatings testing methods and standardisation, but special emphasis is focused on environmental problems. Main goal is to facilitate a fusion of economic sectors of EU and Central Europe in the area of SME and increase safety of the environment. Staff exchange will take place with support for young scientists from EU and CORPROT in order to establish closer professional contacts as well as to prepare a set of proposals for FP 6.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of Electrochemical Peptide Nanosensors for protein and antibody detection' (2007-2013).

assistant: **Innovation**

The overriding goal of the proposed research program is the development of novel reagentless, electrochemical peptide based sensors for the detection of multiple diagnostic proteins.  The approach, which will utilize electrochemistry to monitor the binding-induced folding of peptide/polypeptide used as recognition elements, will be rapid, specific, convenient, and critically, selective enough to be employed directly in blood serum and –we propose- whole blood. This goal will be achieved bringing together an international and interdisciplinary group of research teams and building a collaborative environment for research, innovation and technology transfer in the field of electrochemical nanosensors.This program will allow the exchange of knowledge and expertises through training visiting periods of early stage and experienced researchers. The training will involve each single aspect of sensor development. For this reason, the research teams selected encompass all of the requisite expertises and each of them has a particular focus on a single step of sensor production and testing.The outcome of the fellowship will be crucial for the early stage researchers involved. This in fact will strengthen their scientific knowledge through a focused training at the host institutions and will facilitate the acquisition of experience in new, interdisciplinary fields at the interface of analytical chemistry, electrochemistry, molecular biology and clinical chemistry. The program will also allow the exchange of experienced researchers. This will give the possibility to build a strong net of collaboration, which will be very important for future careers of the involved scientists. The laboratories involved have similar objectives but with completely different scientific approaches and ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Creating a habitable planet: the roles of accretion, core formation and plate tectonics'.

assistant: **Innovation**

The Earth formed ~ 4.5 billion years ago, from accreting particles of dust and primitive meteorites. It is the only habitable planet in our solar system and has a unique history of extended accretion and core formation coupled with active plate tectonics. Accretion and core formation would have defined the initial elemental composition of the Earth’s interior whereas plate tectonic processes controlled chemical exchange between the Earth’s surface and interior and the distribution of elements between major geochemical reservoirs. The overarching goal of this proposal is to define the roles of these processes in the chemical evolution of the Earth and hence in the creation of a habitable planet.In order to achieve this goal I propose to investigate the partitioning of new stable isotope systems such as Ge and Se in high-pressure experiments that simulate core formation. This novel, multidisciplinary approach will provide some of the first direct constraints on the extent to which these volatile elements  were partitioned into the core. We will use this information to address the fundamental issue of whether the Earth acquired its volatile elements inventory early, during core formation, or subsequently, as part of a “late veneer”. The second major theme of the proposed research uses Fe, Zn, Mo and Se stable isotopes to trace the cycling of Fe and S during subduction, the tectonic process where one plate sinks beneath another and is recycled into the Earth’s deep interior. The goal of this project is to understand the impact of subduction on the chemical and redox evolution of the Earth’s interior and the relationship between tectonic recycling and the rise of oxygen in the Earth’s atmosphere ~ 2.5 billion years ago. This theme will focus on samples of relict subducted pl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Tracing Ancient Grinding Technologies in the Neolithic - Bronze Age Transition'.

assistant: **Objectives**

Grinding technology (i.e. querns and handstones) is an integral part of the material culture of prehistoric societies, involved in numerous human productive activities, incorporating socioeconomic and cultural significance. For decades the study of grinding systems in the context of Greek prehistory remained limited with only a few exceptions. The GrindTrace project aspires to change the research landscape and enhance our knowledge regarding this understudied field, at the same time shedding light on the yet-little-known transitional period from the Neolithic to the Bronze Age. What first appeared to be a gap of about 500-700 years in the evolution of prehistoric societies in Greece, from the end of the 5th to the late 4th millennium BC, is now seen as the result of a combination of low visibility and insufficient research. The assemblage to be analyzed includes over 500 specimens originating from six sites in northern and central Greece. The following lines of investigation will be pursued: a) technological and functional study of the selected artifacts; b) experimental investigation of parameters influencing the grinding systems; c) petrographic characterization of the tools' raw materials; and d) combined analysis of contextual, spatial and temporal information. The proposed multidisciplinary approach integrates elements of archaeology, geology, GIS and tribology, and aspires to use the micro-scale to talk about the macro-scale (human behavior patterns, settlement organization, temporality of habitation). In this framework, I will have the chance to explore various analytical techniques, some of which are particularly underdeveloped. This will help me establish a novel methodological approach, which, besides boosting my potential to lead cutting-edge interdisciplinar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Gendering activism in populist radical right parties. A comparative study of women’s and men’s participation in the Northern League (Italy) and the National Front (France)'.

assistant: **Objectives**

Building on two pilot studies conducted in 2010, the proposed research will explore the gender dimensions of anti-immigration social movements in contemporary Europe. This will be done through a comparative analysis of activism in two populist radical right parties: an ethnographic and documentary study of activism in the social and cultural associations linked to the Northern League party (NL) in Italy and to the National Front party (NF) in France. During the applicant’s earlier research on the NL, it became clear that the themes of women’s rights and gender equality are increasingly mobilised in instrumental ways by this party, seeking to attract women’s votes. This corresponds to a recent radicalisation of the NL’s discourse, which in the past decade has increasingly targeted migrants coming from Muslim countries: in this discourse, immigration is associated with sexual violence and gender conservatism. The research will mobilise these earlier studies while expanding their focus through a comparative perspective. In examining current developments in the ideology and politics of the NL and the NF, and their attempt to modernise their public image, the proposed comparative research will contribute to ongoing theoretical debates about the articulation of racism and gender as well as about the role played by gender in collective action. The proposed research is ground-breaking in two ways. First, only a minority of ethnographic studies exist which focus on activism in radical right organisations, as sociologists have tended to focus on left-wing social movements. More specifically, very few studies have investigated the role played by women in radical right social movements. Second, the few existing qualitative studies of women’s activism in these organisations fail to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Salmon Time: A More-than-Human History of the Decline of Atlantic Salmon in Modern Ireland, 1853-1970' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

This is the first history of the decline of wild Atlantic Salmon. Wild salmon world-wide are in jeopardy, their existence threatened by a host of factors, from dams blocking their migratory patterns, to ocean warming caused by climate change, to diseases spread by farmed salmon. Atlantic salmon in particular are in freefall, their population fell by more than half between the 1980s and the 2010s. The lives of salmon are intricately bound up with those of humans and other land and sea creatures. Their loss fundamentally impacts wider ecologies, societies, cultures and economies. There is a substantial body of scientific literature devoted to the decline of Atlantic salmon. However, the humanities, and history in particular have neglected this totemic species. The objective of this research is therefore to trace the ecological, social, and cultural impacts of the decline of wild Atlantic Salmon, through case studies of three rivers in Ireland; the Lee, the Erne and the Corrib. An historical approach offers a novel understanding of this crisis, providing a holistic notion of historical harm that encompasses often overlooked connections between social, cultural and ecological change. This project will start earlier than most scientific studies, in order to contextualise the longer human-salmon relationship. Crucially, I offer a new approach to historical time, that centres salmon rather than human temporalities. This will be achieved through the development of a new interdisciplinary methodology for studying ecological loss and decline, which combines traditional archival research with fieldwork and oral history. The project will result in three journal articles, a book proposal, three public history events and a website. The fellowship will provide an opportunity to enhanc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Test facilities in pressurized water or steam for assessment and improvement nuclear safety' (NICODEME) targeting Sixth Framework.

assistant: **Abstract**

In the frame of nuclear safety and technologies, energy producers put their effort on improvement of safety of existing installations. To reach this goal, large test facilities have been built in the 80?s in order to qualify operational components for commercial Power Water Reactors (valves, safety relief valves, diaphragms, ?).Nowadays, most of these components have been fully qualified so that the research program associated to our facilities has been progressively focussed on the evaluation of the potential offered by advanced components to improve the safety of existing nuclear installations. Our Materials and Mechanics of Components Department also decided to sponsor new opportunities for research teams and users to access to our research infrastructures, more especially the CYPRES and CYTHERE test facilities in pressurized water or steam.The CYPRES test facility performs endurance open/close tests under high differential pressure up to 160 bar and full flow rate up to 100 m3/h, with a maximum temperature of 300°C. The CYTHERE test facility performs endurance tests under thermal shock cycling (differential temperature up to 260°C, pressure up to 176 bar and full flow-rate up to 100 m3/h) on valves and fittings and other components. Both facilities can also be linked to obtain more advanced characteristics.The CYPRES and CYTHERE facilities are a part of the Materials and Mechanics of Components department, composed of multidisciplinary teams at international level, which offers a good scientific environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Cellular proliferation and apoptosis in the parathyroid glands - effects of phosphate in vivo and in vitro'.

assistant: **Objectives**

Research objectives and content Most patients with chronic renal failure develop secondary hyperparathyroidism, characterized by increases of parathyroid gland size and serum parathyroid hormone levels. Since secondary hyperparathyroidism is frequently associated with serious complications like renal osteodystrophies, atherosclerosis, soft tissue calcification, anemia, myocardiocytic fibrosis, etc., it's essential to prevent it. Furthermore, secondary hyperparathyroidism can be present even after renal transplantation, with frequent development of persistent hyperparathyroidism, characterized by refractoriness to the usual therapies. Hyperphosphatemia is a very common finding in chronic renal failure. We have studied the role of hyperphosphatemia in the impairment of secondary hyperparathyroidism, and have demonstrated direct effects of phosphorus increasing parathyroid hormone synthesis and secretion, and inducing a hyperplastic pattern in the parathyroid gland with an evident increase in the gland volume. Since the mechanisms leading to parathyroid gland hyperplasia are poorly defined, it's extremely relevant to study in depth the molecular and cellular mechanisms of parathyroid cell proliferation and programmed cell death. This project includes: i) the study of the effects of phosphate on molecular markers of parathyroid cell hyperplasia, to provide additional knowledgment about the genesis of this pathology, ii) the investigation of a possible phosphate-induced monoclonal pattern of proliferation, by which refractoriness to therapy can be explained, and iii) the assessment of the role of phosphate and calcitriol on programmed cell death (apoptosis), which could contribute to develop new treatments of hyperparathyroidism in chronic renal failure. Training content (ob