RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Patterning the early vertebrate central nervous system' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Understanding the mechanism whereby early neural induction signals activate evolutionarily conserved gene networks to generate the basic pattern of the animal central nervous system ( CNS) is a central unsolved problem in Developmental Neurobiology. The intention for this project is to co-ordinate the complementary expertises of five specialist partners who have already made outstanding contributions to this field to elucidate different but inter-connecting aspects of neural patterning. We investigate how: - The neural activation and transformation signals generate an antero-posterior pattern of differentiation in the early neural plate. - The Otx and Emx gene families respond to these signals and mediate patterning of the forebrain. - Hox genes and other regulatory gene families respond to these signals to mediate segmental patterning in the hindbrain. - The irx gene family modulates the antero-posterior pattern of the CNS. - Hox genes regulate the functional architecture of the CNS by specifying motoneuron identities. Each of these collaborative investigations involve extensive input from two or more partners, and the investigations themselves are strongly interconnected. We will exploit and compare at least two different vertebrate systems (mouse and Xenopus), to enable elucidation of universal principles. The question at issue has always been considered to be of paramount importance, but it is only now that experimental tools and theoretical concepts begin to be available to initiate this effort, and it is easy to predict an imminent explosion in this field. Europe has, so far, shown the way in this area of Developmental Neurobiology and we think that it is now essential to integrate our efforts in a concerted collaborative effort at the community level in order to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Automatic 3G/4G Radio Access Network Planning and Optimisation - A High End Computing Approach' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

3G/4G cellular networks will play a very important role in broadband communications and ubiquitous computing in the foreseeable future. Network planning plays an important role when building a new network or expanding an existing one. As Radio Access Net work (RAN) accounts for most of the infrastructure cost of a cellular network, careful design and accurate planning of RAN is vital to any operator. While in operation, RAN needs to undergo frequent optimisation. The planning and optimisation of RAN is very complicated.Traditional planning methods require experienced planners to manually select and configure network elements. As there are many network elements with many parameters to configure, it is very unlikely to find the optimal network configuration using such a method. Approaches and tools that can automate RAN planning and optimisation are urgently needed by the mobile industry. Automatic 3G/4G RAN planning and optimisation is highly multidisciplinary, as it requires expertise in telecommunications, operations research (OR) and computing. Automatic 3G/4G RAN planning and optimisation requires large computing resources, both in term of CPU time and memory demand.In order to find a near-optimal solution for networks of realistic sizes in acceptable time frames, the recent developments in HEC (High End Computing) should be used. In this project, how to automate 3G/4G radio and transmission network planning and optimisation will be investigated. Innovative approaches to decompose RAN planning and optimisation will be developed. The latest development in HEC will be used to speed up the planning and optimisation process. The success of the project will have big impacts on 3G/4G RAN planning and optimisation. The project will last four years, and w ill host four 3-yea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PUBLIC AWARENESS ON RESEARCHER?S CAREER IN GREEK SOCIETY' in the context of a Sixth Framework call.

assistant: **Objectives**

The main objective of the PARIS project is to contribute in raising awareness on the role and the impact of the profession of the researcher in Greece in regional and national level aiming to foster the public support for the researcher?s profession and attracting more young people into research careers. The target groups are research community, students, industry, Government, Local Authorities and public in general. The duration of the project is 6 months. A consortium of 12 partners, universities, research organizations, public television channel ERT-3, the Greek Mobility Centres Network, Technology Museum of Thessaloniki, under the coordination of GSRT, the national research policy organization will undertake the project implementation. To achieve the aforementioned objectives the project will focus on the following awareness activities: Activities in national level (science weeks, media), in local level (school visits, symposia, workshops, info-days, exhibitions, seminars), development of a portal as mean for a dialogue between science and society, dissemination of projects results The expected results are summarized as follows: Effective awareness, arising people?s sensitivity in researcher?s problems, Encouragement of the establishment of a dialogue between scientific, research, industrial world and public, Attraction of the young people in professions related to the new sciences and innovative technologies, Support of the innovation spirit especially among the youngsters, Promotion of the better understanding among the general public of the catalytic role of research and technology in contemporary societies. Finally, it has to be emphasized that the objectives of PARIS project are in line with the general objective of HRM EC policy and the ?2005 Researchers in Eu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Bosnian Bones, Spanish Ghosts: 'Transitional Justice' and the Legal Shaping of Memory after Two Modern Conflicts'.

assistant: **Innovation**

The proposed research entails an ethnographic study of two contemporary cases of post-conflict reconciliation: one, the Bosnian case, where international intervention ended conflict in a stalemate and went on to instigate a decade-long process of transition; and the other, the Spanish case, where a nationally-contrived pact of silence introduced an overnight transition after Franco's death a pact now being broken nearly seventy years after the country's civil war concluded. Both societies witnessed massive violations of international humanitarian law. Both societies are presently exhuming, identifying and re-burying their dead. But their trajectories of transitional justice could not have been more different. This project will investigate how Law shapes cultural memories of wartime atrocity in these contrasting scenarios. How do criminal prosecutions, constitutional reforms, and international rights mechanisms, provide or obfuscate the scales into which histories of violent conflict are framed? Does the systematic re-structuring of legislative and judicial infrastructure stifle recognition of past abuses or does it create the conditions through which such pasts can be confronted? How does Law shape or inflect the cultural politics of memory and memorialisation? And most importantly, how should legal activity be weighted, prioritised and sequenced with other, extra-legal components of peace-building initiatives? The ultimate goal of this project will be to mobilise the findings from the two field-sites to suggest a more nuanced assessment of Law s place in transitional justice. Arguing that disparate historical, cultural and legal contexts require equally distinct approaches towards social healing, the research aims to produce a Post-Conflict Action Framework an architec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Enabling renewable energy SMEs to develop submersible and cost-effective vertical axis turbines for energy exploitation in ultra low-head streams.'.

assistant: **Objectives**

The project focus on enabling competitiveness and internationalisation of the large European renewable energy technology sector mainly dominated by SMEs, who has 1/3 of the global market, which is worth more than EUR5Bn. However, the SMEs in the European RET sector are loosing competitiveness compared to its non- European rivals due to: innovative developments outside Europe; a weak European domestic market; as well as environmental and legal constraints. An attempt to make use of the renewable energy in ultra-low-head streams, a resource insofar unexploited, by employing a vertical axis water turbine with adjustable but pre-programmed foils has shown promising results, but simultaneously identified some technical limitations that has to be dealt with before the concept can be industrialised to its potential, mainly sub-optimal efficiency and energy outtake and high maintenance costs due to vibrations. Our idea is to develop cost-effective Darrieus type vertical axis water turbine efficiently exploiting a minimum of 84,3 per cent of the theoretical available energy to be placed in ultra-low head streams to increase the European production of renewable energy thus reducing the import and consumption of fossil fuels. With:A novel design of a highly efficient, hydrodynamicaly stable, scalable and submersible vertical axis water turbine with adjustable sturdy foils, with an installed capacity of minimum 200 kW incorporating:An innovative, autonomous and efficient constellation of a self-optimising pitch control unit, an embedded sensor configuration and drive motors facilitating real time fine incremental angle-adjustments of the foils up to a torque of 1000 NM, at a precision of 0,5 degrees relative to the foil carrier, at a delay of maximum 0,1 ms, based on sensing of pre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrated Biotechnological Solutions for Combating Marine Oil Spills' (2007-2013).

assistant: **Innovation**

Kill●Spill delivers innovative (bio)technologies, which can be integrated to the real sequences of state-of-the-art actions used currently to cleanup oil spills. The catalogue of Kill●Spill products & technologies is based on a review of technology & knowledge gaps in approaches of oil spill disasters and brings appropriate tools for 1st response, follow-up, and longer-term actions, specifically tailored to the versatility of oil spills. Kill●Spill develops chemicals & biochemicals to be used for 1st response actions to disperse/emulsify oil and materials enabling the containment and sorption of oil, preparing the field for the follow-up actions. Kill●Spill develops (Bio)technologies aiming at intensified biodegradation processes by bioaugmentation/biostimulation as follow-up and longer term actions in aerobic/slight anoxic compartments. Kill●Spill develops (bio)technologies adapted for the remediation of anoxic/anaerobic fresh & chronically polluted sediments. Kill●Spill compiles knowledge on dispersion/sorption and biodegradation processes to produce multifunctional products, which are suited for follow-up and longer term actions. The multifunctional products address the necessity for integrated bioremediation (bioavailability, metabolic requirements, etc.) and are efficient along the whole redox gradient from surface water to sediments. The products/technologies are field-tested in open sea oil spills and large mesocosms to unravel the champions products & technologies. The (bio)tools are benchmarked with existing solutions using cutting-edge analytics, biosensors, and omics and checked for eco-efficiency to merit green label. Kill●Spill consortium is multidisciplinary and gathers 33 partners from 12 EU and EU-associated countries and USA; 18 research & academic inst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Single cell level intravital imaging of response, tolerance, and resistance to targeted therapies', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Oncogenic signalling by kinases presents a significant opportunity for cancer therapy. The B-Raf selective inhibitor, Vemurafenib, has shown great effect against B-Raf mutant melanoma patients. However, drug resistance emerges in nearly every case. Various mechanisms underlying this resistance are described, however these approaches usually overlook the heterogeneity of the tumour microenvironment, and do not provide information about the temporal aspects of drug response and eventual emergence of resistance. Therefore, uncovering the spatio-temporal heterogeneity, i.e., when, where, and how melanoma cells respond to drug and acquire resistance in a complex tumour microenvironment is the key step toward the comprehensive understanding of resistance mechanisms. To tackle these problems, we will investigate the tolerance and resistance to B-Raf inhibitors with single cell resolution in vivo. We have established melanoma cell lines stably expressing EKAR-EV biosensor that reports ERK activity in living cells. In vitro, the melanoma cells show homogenous responses to BRaf inhibitors, whereas intravital analysis indicate that there is considerable heterogeneity in ERK activity within tumours. This cannot be attributed simply B-Raf mutation as all cells contain the oncogene, and we hypothesize that additional signals from the microenvironment activate ERK, possibly putting the neighbouring melanoma cells in drug-tolerant state. Similar mechanisms are possible at metastatic locations. The tumour microenvironment of CNS metastases is quite different from those of other organs, it is particularly enriched in RTK ligands. In the longer term, we will study how metastatic melanoma cells may respond to and tolerate the drugs in the CNS. In summary we aim to identify the micro-enviro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Statistical Mechanics and transport phenomena in Active Colloidal Solids' (StaMACS) under Horizon 2020.

assistant: **Objectives**

The objective of StaMACS is to uncover the dynamics of an active and loosely packed magnetic colloidal crystal. This system will consist of repulsive paramagnetic particles immersed in a bath of light-driven bacteria. We will have two independent ways to tune the interactions: 1) An external magnetic field will control the strength of the dipolar repulsion between colloids. 2) The intensity of light will control the motility of bacteria and thus the particle’s induced activity, both locally and globally. By combining experiments with simulations and theoretical analysis, we will reach a general understanding of this system’s dynamics, study its melting and crystallization transitions and examine how a local change in activity propagates throughout the crystal.  Our findings will unveil the properties of a novel out-of-equilibrium system: an active colloidal solid.  Furthermore, this work will stimulate theoretical investigation related to the kinetics of such systems, with strong implications on understanding the fundamental process of crystallization in the presence of activity. By a two-way transfer of knowledge, StaMACS will bring numerous mutual benefits to both the researcher and the host institution. Its results will represent a major contribution to the soft and active matter field with direct applications in physics, biology and material science.Descriptors: Active Matter, Soft Matter, Statistical Mechanics, Magnetic Colloids


**Keywords:** Active Matter, Soft Matter, Statistical Mechanics, Magnetic Colloids
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Multi-level Circular Process Chain for Carbon and Glass Fibre Composites'.

assistant: **Objectives**

Each year about 110.000t of carbon fibre composite parts and 4.500.000t of glass fibre composites are used. 98% of these parts end up in landfills at the end of their life. To address this problem the MC4 project aims at establishing a multi-level circular process for carbon and glass fibre composite. Multi-level means that processes will be developed for short-term implementation with immediate impact and for the longer term with a wider impact on industry. Carbon and glass fibre have substantially different costs and the project takes this into account by developing economically feasible procedures that are based on chemical matrix/fibre separation for carbon fibre and on a new type of resing for the direct re-use of the composite for glass fibre. Quality grading of the recycled material will be a key element to ensure a proper use in the different domains. Within the supply chain investigated in the project the goal is to achieve a recycling rate of at least 60%.As an additional benefit, the project will enable European material manufacturers to develop their own, patented processes for manufacturing of recycled material. Currently, 80% of the manufacturing of virgin carbon and glass fibre is taking place outside of Europe and the manufacturing technologies used inside of Europe are often licensed from foreign countries.MC4 puts particular emphasis on the design and manufacturing of best practice examples of parts made from recycled materials. For five different domains, including automotive, aerospace, sports equipment, boats and urban furniture, composite products will be manufactured, with the aim of demonstrating the use of recycled material and enhancing the demand side for recycled material in the different domains.The consortium includes process developers, ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Deformable Phase Plates for Adaptive Optics applied to Ophthalmology and Microscopy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Adaptive optics (AO) technology is pivotal in modern optics, addressing the critical need for advanced imaging capabilities beyond the limitations of traditional fixed lenses. Traditional methods are inadequate for today's complex imaging requirements, particularly in medical diagnostics, where precise, adaptable imaging is crucial for early disease detection and treatment. Phaseform's innovative Deformable Phase Plates (DPPs) cater to this essential need, offering dynamic, high-resolution imaging solutions that adapt in real-time to changes in the subject or environment, significantly enhancing diagnostic accuracy and potential treatment outcomes.Phaseform, a University of Freiburg spinoff, has transitioned from prototype to advanced product development, securing a strong IP portfolio. The technology’s broad applicability promises substantial market penetration in optical microscopy and ophthalmic diagnostics, sectors poised for growth. Validation by key industry players forecasts a lucrative revenue stream, enhancing Phaseform's market position.The company’s strategic progress is bolstered by the EIC Accelerator project, aiming for commercial scalability and market readiness. This includes performance enhancements, cost reduction strategies, and market engagement plans. EIC funding is crucial, enabling Phaseform to navigate the niche market landscape effectively, avoiding restrictive partnerships that could limit broader market access.Phaseform's DPP technology is set to transform optical imaging, offering significant benefits across healthcare, research, and manufacturing, cementing its status as a leader in high-resolution imaging innovations.


**Keywords:** adaptive optics, ophthalmology, optics, micro (system) engineering, high-resolution imaging, microscopy