RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mapping Practices under Pressure. The Everyday Experience of Socio-Economic Change in Deindustrialising Cities, 1960-2000' (MPP).

assistant: **Concept**

The project uses a Geographic Information System (GIS) to map how everyday practices changed in European cities under the pressure of deindustrialization between the 1960s and 1990s. It will substantiate the hypothesis that the processes of social transformation, which have led to phenomena of social and cultural polarization, cannot simply be deducted from socio-economic factors alone, but hinge on the (re-)production of social status, gender and ethnicity in everyday routines. Spatial analysis using GIS offers a suitable tool to reconstruct the relevance of practices in processes of social transformation because everyday routines aggregated around places, nodes and networks, and these localizations in turn become important references in defining social relations. Accessing and analysing information about past practices brings with it methodological challenges which the project addresses by combining oral history interviews with digital mapping techniques. With this, the project will contribute to the ongoing efforts to devise methodologies, which allow to further expand research in the field of digital spatial humanities into the realm of qualitative data and “deep mapping”. It will build on the extensive expertise of the HI (University of Antwerp Centre for Urban History) and will be integrated in the HI’s initiatives to refine the DARIAH and CLARIN infrastructures in the ‘Spatial Humanities’. The project will therefore contribute to the field of contemporary urban history and to the methodological advancement of GIS as a tool of historical research.


**Keywords:** Urban History, Deindustrialization, Social Practices, Historical GIS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'High tech Inliner for ISO tank containers'.

assistant: **Concept**

The global tank container fleet has grown almost 50% from 2013, reaching 508,000 units by the end of 2016 since bulk shipping made possible is much more efficient compared to traditional transport methods. Thus, ISO tank containers have developed for intermodal carriage of bulk liquids ranging from non-hazardous to hazardous liquids, eliminating the risk of spillages through transferring liquids from one vessel to another providing an extremely safe, secure, and versatile mode of transportation. Nevertheless, nowadays the intensive use of ISO tank containers is constrained by the need of cleaning after each use to be ready for its next load. This task coupled with the insufficient number of cleaning stations entails higher direct costs (€250-1200/cleaning) but also indirect ones since the containers are stocked several days limiting their availability. These lead towards logistic inefficiencies, such as empty return journeys due to prior cargo constraints. Moreover, the lifetime of ISO tank containers, is highly dependent on the cargo being shipped and frequency of cleaning. On the other hand, flexitanks-an alternative solution-poses serious concerns regarding the possibility of spillages, unused space and their installation is expensive. Mega-Inliner® aims to revolutionize the bulk liquid transportation industry by introducing the first one-use high-tech Inliner for ISO tank containers designed for intermodal transport. Removing the need for cleaning the tank after discharge, it eliminates all the concerns associated with the use of ISO tank containers. Thus, a huge optimization of logistics is realized allowing for transport costs reductions of 20-75% depending on type of current packaging used, liquid cargo and volume transported. Having set brewery sector as our ini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Model Theory of Groups' (MODGROUP) under Seventh Framework.

assistant: **Objectives**

The topic of the project is to develop new connections between model theory (a subfield of mathematical logic) and algebra, involving applications to group theory. We propose to work on some questions regarding groups definable in various important first order structures: o-minimal, without the independence property (NIP) and algebraically closed valued fields (ACVF) and others. Especially, we are interested in model-theoretic connected components of such groups. The quotient of the group by one of its model-theoretic components connected with `logic topology' is a quasi-compact topological group, and can be seen as a canonical set-theoretical invariant of first order theory of a given group. We plan to investigate in this context groups of Lie type (e.g. Chevalley groups), finitely generated nilpotent groups and algebraic groups over valued fields. We aim also to initiate a systematic study of the model theory of affine buildings, and of associated groups of automorphisms. We intend to combine classical Lie theory, results about covering numbers of Chevalley groups and some applicant's achievements. Working on affine buildings we use the classification of Bruhat-Tits buildings. The solutions to our conjectures and questions give us a results of new kind not only in model theory but in algebraic group theory and in additive combinatorics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A search for novel drugs to treat the haemoglobinopathies.', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The treatment of sickle cell anaemia and ß thalassaemia is at present inadequate, expensive and unsatisfactory. There is an urgent need for novel treatments and two possibilities can be envisioned. Firstly the treatment with small molecules that interfere with the transcription process and may reactivate the y-globin genes which are normally suppressed in adults. This approach is the subject of this proposal. The second possibility would be gene therapy, which is the subject of another proposal. Here we propose to make mouse models which can be used to screen and test compounds that interfere with y globin gene suppression and to study factors that are important in the switching from y to ß globin genes. The identification of such factors may provide a rational approach to design molecules that interfere with y and ß globin gene expression. The objectives are: 1. The generation of transgenic mice which model human thalassaemia and sickle cell anaemia. 2. The generation of transgenic mice which carry a complete human ß-globin gene domain in which one of the foetal globin genes expresses luciferase. 3. The generation of erythroid cell lines from the luciferase mice (2 above) by infection with Friend virus or crossing with transgenic mice that carry a GATA-T antigen construct (Ottolenghi). These cell lines will be used in a robotic screen for novel therapeutic compounds that can activate y globin gene expression in the adult. 4. The testing of candidate therapeutic compounds in transgenic mice and human erythroid cell cultures. 5. The identification of transcription elements and their cognate transcription factors important for y globin gene activation/suppression and the switch to ß globin expression. Keywords: Haemoglobinopathies, drug discovery, transcriptional regulati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Single molecule characterisation of biological nanopores in action' in the context of a Horizon 2020 call.

assistant: **Objectives**

Biological nanopores are nanometre-scale holes in membranes created by transmembrane proteins. In nature, nanopores come from pore-forming toxins or exist as transporters in bacteria. To date, they have been successfully used for an impressive variety of applications ranging from DNA sequencing through to the measurement of function-related motions of enzymes. Planned developments using nanopores include their integration into biosensors for the detection of analytes from blood. However, to reach their potential, miniaturisation and parallelisation of electrophysiology setups and an in-depth understanding of how nanopores exert forces on their substrates during trapping and translocation are required. There are currently no experimental techniques which provide access to this information. Single molecule studies using the optical tweezers (OT) have, over the past decade, become the gold standard in high resolution measurements of forces in biological systems, including observations of sub-nanometre enzyme kinetics, protein folding and protein degradation machinery in action. I propose the development of low-cost, microfluidic-based tools for the study of biological nanopores using OT. The technologies arising from this work will provide an unprecedented insight into the function of biological nanopores and will enable studies of any other transmembrane protein system, many of which are also of great medical importance. The findings will also lay the groundwork for peptide-sequencing and biosensor technologies for personalised medicine. The combination of my skills in single molecule biophysics and Prof. Maglia’s expertise at the forefront of biological nanopore technologies is ideal for the successful completion of the research objectives. Through the planned interdisci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Spiritual Brains and Embodied Minds: Neural Bases of Self-Transcendence and Empathy' in the context of a Seventh Framework call.

assistant: **Objectives**

The representation of our own and others’ mental events is strongly linked to mapping internal bodily states (embodiment). At the same time, the ability to transcend actual body perceptions and actions (self-transcendence) and to project self-images into scenarios that are not entirely transparent to sense modalities (spirituality) is inherently linked to human beings. Recent neuroimaging studies have addressed the issue of the neural correlates of spiritual experiences and empathy. Information on how the activation of spiritual self-representations impacts the embodied understanding of others’ mental states, however, is inconclusive and causative evidence on this link is scarce.SPIRIT aims to study the cognitive processes and neural mechanisms underpinning the influence of self-transcendence and spirituality on the embodied instantiations of social perception and empathy. In particular, SPIRIT will study the:a) Neural correlates of implicit and explicit spiritual representations of the self;b) Effects of the activation of self-transcendence representations following spiritual word priming or meditation practice on the cognitive processes and the neural correlates of empathy for pain.c) Short-term plastic changes of spiritual self-representations and empathy induced by neurophysiologic regulation of neural activity.Integrating the brain stimulation expertise of the fellow with learning state-of-the-art neuroimaging methods, SPIRIT fosters a multimodal approach to explore how the complex neurofunctional organization of the human brain allows the development of spiritual self-representations and the reaching of more abstract (dis-embodied) forms of social perception. This approach will be disseminated in academic seminars and in international public conferences for lay pe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Decentralized power generation plants based on planar sofc technology - proof of concept ('PROCON')' (PROCON) under Fifth Framework.

assistant: **Objectives**

The project aims to test the feasibility (i.e. prove the concept) of grid connected stationary power generation plant based on planar Solid Oxide Fuel Cell (SOFC) technology by designing, building and operating a system with an integrated, thermally self-sustaining 20 kW SOFC module. By pursing a planar SOFC stack design which, because of its lower temperature of operation, is potentially significantly cheaper to manufacture than other geometries ans should reduce the balance of plant costs, a key objective of the programme, that fuel cell systems should meet commercial cost targets, is addressed. Due to their high efficiencies and very low emissions, these systems will contribute significantly to meeting environmental objectives. It is intended that the knowledge and experience gained in the project will be exploited in a following project development phase that the assembled consortium is well placed to perform.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'POLYRISK - Understanding human exposure and health hazard of micro- and nanoplastic contaminants in our environment', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The POLYRISK project aims unraveling the risks of microplastic and nanoplastic particles (MNP) that are ubiquitous in our environment and are likely to be entering the human body via inhalation and ingestion. The most bioavailable low-micron and nano-sized MNP, pose the biggest analytical challenges or today’s analytical chemists. Existing knowledge about the adverse pro-inflammatory effects of airborne particulate matter and nanoparticles, combined with pro-inflammatory evidence of MNP exposure observed in animal models and in vitro pilot tests with human immune cells, suggests that MNP may cause immunotoxicity in humans. Occupational exposure of workers to fibrous MNP can indeed lead to granulomatous lesions, causing respiratory irritation, functional abnormalities and flock worker’s lung. Currently, human health risk assessment protocols specific to MNP are not available and key data is missing. This hampers science-based decision making.On this backdrop, POLYRISK’s human risk assessment strategy will combine highly advanced sampling, sample pretreatment and analytical methods to detect MNP in complex matrices, up-to-date fit-for-purpose hazard assessment technologies and multiple real-life human exposure scenarios. We will focus on key toxic events linked to several chronic inflammatory diseases. The consortium uniquely brings together interdisciplinary experience and know-how on quality-controlled chemical analyses of MNP and additives, intestinal and respiratory toxicity models, human exposure epidemiology, immunotoxicology and real-life high-exposure studies. POLYRISK’s novel human risk assessment strategy is based on mechanistic reasoning and pragmatically accommodates the complexity of the MNP toxicant class. Building with ground-breaking science, stakeholder e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ambulatory Bio-Artificial Lung' (AMBULUNG) under Seventh Framework.

assistant: **Objectives**

Chronic obstructive pulmonary disease (COPD) is the 4th leading cause of death worldwide. Long-term respiratory support increases the life expectancy and the quality of life of COPD patients and decreases the cost of care. Currently available artificial lungs, such as Novalung’s iLA system, fail after ~ one month, mainly due to thrombus formation at the blood/machine interface. The size of current systems restrict patient mobility. We aim to create a wearable bioartificial lung (AmbuLung) for long-term application in an outpatient setting. The goals are to (1) miniaturise the existing iLA system, including the supporting technology and patient monitoring system; (2) cellularise the diffusion membrane with endothelial cells to decrease thrombogenicity and to increase the gas-exchange rate; and (3) evaluate the developed system in pre-clinical and clinical studies.The innovation includes (i) development of a novel alveolo-capillary gas-exchange membrane, functionalised with bioactive molecules and seeded with endothelial cells, ii) miniaturisation of mechanical and electronic device components, and (iii) novel vascular access system. For cellularisation, endothelial cells  derived from FDA approved clinical grade human pluripotent stem cells will be used. Cell differentiation, scale-up, seeding, and maintenance will be performed using established automatable and scalable dynamic bioreactor technology. A mathematical model will be developed to predict and refine the function of this complex system in vitro and in vivo.AmbuLung will be evaluated in a pig model, assessing functionality, and non-thrombogenicity. The data will provide information required for potential clinical transfer. If successful, a clinical trial will be carried out on 5 COPD patients after acquisition o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dynamics of enhancer-promoter communication and transcription in mouse pseudo-embryos' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Embryonic development requires the coordinated execution of sequential gene expression programmes in space and time. This complex regulation is achieved by enhancers, cis-regulatory elements that relay spatiotemporal regulatory information to target promoter(s) in response to transcription factor (TF) binding. While enhancers (E) and promoters (P) are often separated by large linear genomic distances, they can come into close 3D proximity through E-P contacts. However, the mechanisms regulating the temporal dynamics of E-P communication and transcription remain elusive. In the nucleus, chromatin is folded by loop extrusion; disrupting this process abrogates large-scale architecture, yet has only minor effects on E-P contacts and gene expression. Also, the contribution of TFs bound at enhancers and promoters to E-P communication is still unclear. Importantly, previous studies mostly investigated these mechanisms in model systems where chromatin structure and transcription are at steady state, thus neglecting their dynamics. This proposal aims to investigate the causal role of loop extrusion and TF binding in the temporal dynamics of E-P communication and transcription during mammalian embryogenesis, using gastruloids (cultured pseudo-embryos) as a paradigm. This will be achieved through two objectives: (1) mapping how E-P contacts, TF occupancy and transcription evolve over developmental time; and (2) perturbing loop extrusion and TF occupancy with targeted protein degradation at specific developmental time windows. As a readout, I will combine genomic and imaging technologies. Genomics will provide a genome-wide view of changes in E-P contacts and transcription averaged across cells, while imaging will determine at selected loci whether these changes co-occur within ind