RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Keeping the spindle in shape: identification and characterization of new components involved for spindle formation', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

During each cell division a cell needs to distribute the genetic material equally to two daughter cells. To segregate chromosomes the cell uses a macromolecular machine: the bipolar spindle.A bipolar spindle forms also in vitro, in Xenopus M-phase egg extract, a system of extreme value to analyse the function of individual spindle components in a simplified context.Pioneered studies in egg extract led to the mechanistic insight of the role of the small GTPase Ran during mitosis. Ran-GTP was shown to regulate microtubule nucleation by releasing the inhibitory effect of import adaptors from factors like TPX2, in the proximity of the chromosomes.We have used the Xenopus extracts to identify additional Ran effectors involved in spindle bi-orientation. Amongst the proteins found, we identified a new protein, which during the course of our studies was reported to be over-expressed in human hepatocellular carcinoma (therefore called HURP).In this project we want to:- Characterise and analyse the molecular function and interplay of the newly identified component of the spindle both in vivo and in vitro.- Identify new proteins potentially involved in spindle assembly.- Discover potential relationship between deregulation of these proteins with specific types of cancer.For this purpose we will employ both the Xenopus egg system and mammalian cell lines, in order to combine the in vitro biochemical experiments with the temporal and spatial requirements observed in vivo. Moreover, analysis of biological samples from different types of cancer will indicate possible links of the proteins to oncogenesis.Given that mitotic defects and aneuploidy is a crucial hallmark associated with high malignancy and poor prognosis of cancer, the outcome of the studies outlined in this proposal may a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'NItrate REcovery CApacity Status' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Nitrate pollution remains a significant concern for water quality. Since the 90s, Europe has been actively working to reduce nitrate levels and improve water quality. Yet, restoring water quality is a slow process as nitrates may remain for decades within aquifers as a legacy. While imperative, assessing Nitrate Recovery Capacity (NRC) faces challenges due to strong variabilities in nitrate transfer times and percentages removed by bacterial consumption within anoxic zones, often requiring intricate models. Here, we propose to leverage an innovative regional-scale assessment method to investigate the correlation between NRC and a readily accessible catchment attribute: lithology. Comparing nitrate concentrations with proxies of conservatively transferred element, NIRECAS determines the nitrate reactivity and legacy of a region. Within consistent geological contexts, the method analyzes the correlation between these factors and lithology while providing uncertainties of the correlation estimates. Our objectives are to (i) investigate the control of lithology on nitrate reactivity and legacy using 200 pilot sites in the Armorican Massif (France) taken as a first experimental region and (ii) extend and generalize the methodology to other European regions. Our deliverables include (1) a methodology for regional scale NRC mapping using available lithology databases, (2) maps of NRC for one to several European regions where lithology is found to be the primary controlling factor, (3) a user-friendly interface to a priori assess the percentage and transfer time of nitrate removed.This should provide key information on the ability of vulnerable regions to restore water quality while catching the legacy of past agricultural practices at the relevant resolution. Besides, NIRECAS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NUTRITIONAL AND HEALTH IMPACT OF TRANS-POLYUNSATURATED FATTY ACIDS IN EUROPEAN POPULATIONS' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The objectives of this project are to investigate the metabolism of trans-polyunsaturated fatty acids and determine their effects on risk factors for coronary heart disease in humans.At the present time, there is great concern among clinical and nutritional experts about the content of transfatty acids in the diet. They are believed to have adverse effects on the incidence of coronary heart disease especially. Nearly all the published work deals with transmonoenoic as opposed to trans-polyunsaturated fatty acids, mainly because it is technically much easier to analyze the former and because there are no suitable standard materials available for work involving the latter. However, polyunsaturated fatty acids are essential components of many biological systems and are the building blocks of the tissue membranes. During processing of fats, especially refining, trans-polyunsaturated fatty acids are formed, but their metabolism and potential effects on disease states have been largely ignored.We propose to rectify this. Our partnership has solved the technical problems of analysis and has the chemical expertise to synthesise the required transfatty acid standards, labelled with stable isotopes (non-radioactive), that are required for human studies. A series of three clinical experiments is planned with human subjects in France, the Netherlands and Scotland to give a cross-section of the European population. Different synthetic fatty acids will be fed in a palatable form, prepared with the assistance of industrial partners in France and Finland, to human volunteers in the three countries. The metabolism of these fatty acids will be investigated and a number of parameters related tot he incidence of coronary heart disease will be measured, by using methods developed by the par
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Universal building blocks for antigen presentation to uncover the flavivirus-directed antibody response', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Flaviviruses are a tremendous burden on global public health. The genus consists of yellow fever virus, dengue virus, and zika virus amongst others. These viruses threaten more than half the global human population and are spreading into new territories. The recent zika virus pandemic stresses the need for a suitable protein engineering toolkit to enable swift development of emerging flavivirus antigens for structural studies, serology and vaccine development. Moreover, the structural determinants of a neutralizing polyclonal antibody response are currently not well understood, in large part for a lack of suitable methods to address the complex interactions of multiple antibodies directed against a heterogeneous, glycosylated viral antigen.With FLAVIR I will use my unique expertise in both mass spectrometry and electron microscopy to develop a comprehensive structural proteomics toolkit for in-depth profiling of the neutralizing antibody response against flaviviruses. Using a combination of novel mass spectrometry-based antibody sequencing techniques, glycoproteomics profiling and electron microscopy, we will uncover how the polyclonal antibody response against flaviviruses is directed by key structural determinants of the Envelope glycoprotein that is displayed on the surface of infectious virions.We will develop new strategies to produce prefusion stabilized E-dimers and ultimately reconstruction of full icosahedral flavivirus-like particles from soluble components. The outlined strategies will be tested and streamlined for broad applicability across the flaviviruses so that it can be swiftly adapted for emerging species and strains. We will characterize our designs with state-of-the art mass spectrometry methods (native MS, mass photometry, HDX-MS) and electron micro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Compositions for use in the treatment of insulin deficiency conditions', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Tens of millions suffer from insulin deficiency (ID); a condition caused by pancreatic β-cell loss. If untreated, ID is a lethal catabolic disease characterized by hyperglycemia. Thus, the focus of ID research and drug development has been mainly on improving strategies to lower hyperglycemia without causing life-threatening hypoglycemia. However, in addition to increased circulating glucose level β-cell loss leads to several “other defects”, some of which (e.g. severe hyperketonemia and ketoacidosis) are life-threatening. Therefore, it is important to develop strategies that in addition to improve hyperglycemia can also rescue the “other defects” (e.g. increased ketogenesis) caused by ID. For example, we have recently published results underscoring the importance of ameliorating hyperglycemia and the “other defects”. Indeed, our data indicate that despite the presence of slightly improved hyperglycemia a normalization of hyperketonemia and hypertriglyceridemia is associated with a significant extension in lifespan of mice with β-cell loss (https://www.nature.com/articles/s41467-019-11498-x). Untreated ID rapidly leads to death. However, since insulin was discovered in the early 1920s, ID has been treated with insulin therapy; an approach that converted this lethal disease into one a person can live with. Yet, insulin therapy is unsatisfactory. Indeed, ID subjects have higher risks for developing kidney failure, blindness, nerve damage, heart attack, stroke, and hypoglycemia. Some of these defects are favored by insulin therapy itself.  Our goal is to diminishing the amount of insulin dosage and hence reducing the risks associated with insulin therapy (e.g. life-threatening hypoglycemia). The present application aims at providing a composition for improving the treatmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multi-level approach for the up-scaling of ultra high temperature energy storage and conversion' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The growing interest for the integration of renewable energy sources, as solar energy, in the global energy mix, increases the need of developing of new methods that will assist on the up-scaling and demonstration of efficient energy storage and conversion technologies. In this regard, advanced modelling methods can be an indispensable tool towards this effort. SHINE aims at developing a holistic numerical methodology – by using in-house codes coupled with commercial software– that will boost the cost-efficient and sustainable electricity production and storage at unprecedented ultra-high temperatures (> 1000 oC). The stepping stone for the modelling activities will be a compact latent heat thermophotovoltaic device recently patented in UPM targeted for energy storage and production at ultra-high temperatures. The core components in such a device are the latent heat thermal energy storage system and the thermophotovoltaic device. The modelling methodology will integrate rigorous multi-physics models (fluid dynamics, heat transfer and optoelectronics) targeted at a component level into a reduced order model (ROM) by using multi-variable polynomial functions. Key in the proposed methodology is the validation of the rigorous models through in-house measurements at ultra-high temperatures that will be undertaken at the host organisation. Key as well is the production of the multi-variable polynomials through artificial neural networks that will be undetaken during the Secondment phase. The whole project is highly interdisciplinary because it integrates highly interrelated diverse disciplines (physics, engineering, optoelectronics, thermo- and fluid-dynamics, photovoltaics and thermal storage, and artificial intelligence-AI) as well as know-how from experiments is a single h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Efficient water use through environmentally sound hydroponic production of high quality vegetables for domestic and export markets in mediterranean countries.' (ECOPONICS) under Fifth Framework.

assistant: **Objectives**

This project will develop the integrated low cost technology ECOPONICS" as a hydroponics system with high water use efficiency (WUE) for water savings and reuse of drainage water. ECOPONICS will produce for domestic and export markets quality fruity vegetables with high nutritional and aroma values to be grown under the unique environmental and climatic conditions of the Mediterranean region, suited to the needs of smallholders as well as horticultural enterprises. A quality label for ECOPONICS produce will be developed."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Promoting the Scientific Exploration of Computational Creativity' in the context of a Seventh Framework call.

assistant: **Objectives**

Creativity is a long-cherished and widely-studied aspect of human behavior that allows us to re-invent the familiar and to imagine the new. Computational Creativity (CC) is a recent but burgeoning area of creativity research that brings together academics and practitioners from diverse disciplines, genres and modalities, to explore the potential of computers to be autonomously creative or to collaborate as co-creators with humans.<br/>As a scientific endeavor, CC proposes that computational modeling can yield important insights into the fundamental capabilities of both humans and machines. As an engineering endeavor, CC claims that it is possible to construct autonomous software artifacts that achieve novel and useful ends that are deserving of the label creative". Overall, the CC field seeks to establish a symbiotic relationship between these scientific and engineering endeavors, wherein the software artifacts that are produced are not only useful in their own right, but also serve as empirical tests of the adequacy of scientific theories of creativity. If sufficiently nurtured, the products of CC research can have a significant impact on many aspects of modern life, with particular consequences for the worlds of entertainment, culture, science, education, design and art.<br/>So that CC can achieve its potential as a future and emerging topic of research and technology development, a range of important coordination actions are needed to solidify and promote the field while engaging with neighboring disciplines. These include focused outreach to researchers in cognitive science, psychology, linguistics, and neuroscience, as well as to practitioners in musicology, literary theory/art theory, design theory, and pedagogy. The goal of the proposed coordinating action is to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Fast photonic integrated circuits for continuous-variable quantum key distribution' (FALQON), addressing dissemination and exploitation.

assistant: **Impact**

Cybersecurity is at a crossroads. Across Europe and globally, critical sectors such as finance, healthcare, energy, and government face increasing risks from data breaches and looming threats posed by quantum computing. Traditional encryption methods, once considered unbreakable, are now vulnerable to “harvest now, decrypt later” attacks, where stolen data can be unlocked as soon as quantum technologies mature. With cybercrime already costing the global economy trillions of euros each year, the need for new forms of secure communication has become urgent.The FALQON project responds to this challenge by advancing a new generation of quantum key distribution (QKD) technology that can safeguard sensitive information in the post-quantum era. The project will develop compact photonic integrated circuits for transmitter and receiver that combine quantum security with the scalability and affordability of semiconductor manufacturing. Over three years, FALQON will transform existing laboratory results into integrated chip-based prototypes, validate the QKD system performance in a relevant environment, demonstrate the system in a real network environments, and engage potential users to ensure alignment with market needs. By uniting cutting-edge research with a clear path to deployment, FALQON will establish the foundation for Europe’s leadership in quantum-secure communication. Its results will strengthen digital sovereignty, reduce reliance on non-European suppliers, and protect the data that underpins our societies, economies, and citizens’ trust.


**Keywords:** Quantum key distribution, quantum cryptography
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'COHErent Setup and Demonstration of Integrated Travel SerVices'.

assistant: **Concept**

Coordination and demonstration embracing all areas of IP4 and targets aiming to assist support ensure and promote a common technical approach across the IP4 to allow integrated and coherent Technical Demonstrations as outlined on Shift2Rail master plan. Te objective will be achieved through different activities involving and promoting the collaborative participation of associated projects (for members of Shit2Rail and from open calls) and the partners involved, through the close technical interface with the different projects and the coordination of the integration activities activities to support and achieve consistency and convergence amongst the different projects, feeding a reliable set of technical packages.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular Machines with Integrated Parts' (MolMacIP).

assistant: **Innovation**

The widespread use of molecular-level motion in key natural processes suggests that great rewards could come from bridging the gap between the present generation of synthetic molecular machines—which by and large rely upon switching of individual components to carry out their functions—and the machines of the macroscopic world, which utilize the synchronized behaviour of integrated components to perform tasks more complex than the sum of the components. The aim of this project is to learn how to integrate the movements and chemistries of different molecular machine components.The proposed program is divided into three themes:Theme 1: Transport and synthesis by nanomechanical substrate positioning. We will integrate switching mechanisms with components that can attach and release a substrate, in order to develop methodology for the nanomechanical manipulation of substrates. We see this theme as reminiscent of the way that substrates are passed between sites in various enzyme complexes in biology.Theme 2: Sequence-selective synthesis using molecular assembly lines. We will integrate reactive molecular appendages with rotaxanes in which the macrocycle moves along a track through brownian motion, in order to develop molecular assembly lines. This theme is reminiscent of molecular-machine-mediated sequence specific polymerisation in biology, such as protein synthesis by the ribosome and DNA synthesis by some DNA polymerases.Theme 3: Transport with chemically fuelled molecular linear motors. We shall integrate ratchet mechanisms with chemically fuelled molecular pumps and walkers and use them to transport cargo between phases and to carry out synthesis via energy ratchet mechanisms induced by chemical fuels. This theme is reminiscent of how biological molecular motors drive c