RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Epigenetic control and impact of mammalian retrotransposons in pluripotent genomes' (EPIPLURIRETRO).

assistant: **Concept**

Almost half of the human genome is made of Transposable Elements (TEs), whose ongoing activity continually impacts our genome. However, little is known about how the host regulates TEs and their genomic and epigenomic impacts. EpiPluriRetro will advance research in a new groundbreaking concept: that TEs are active in our pluripotent genome, and that epigenetic regulation is employed therein to regulate TE activity. LINE-1 retrotransposons comprise approximately 20% of the mammalian genome, and L1 retrotransposition events can create genetic diversity by a variety of mechanisms. From acting as simple insertion mutagens to inducing other complex genomic alterations it is becoming increasingly evident that the activity of TEs is a major force driving human genome evolution. It has been demonstrated that the main mutagenic load associated with TE mobilization occurs during early human embryogenesis (i.e., our pluripotent genome). EpiPluriRetro will examine how epigenetic mechanisms influence LINE-1 retrotransposition in pluripotent cells. To do that, we will combine genetic, biochemical and genomics approaches to identify pluripotent host factors that influence the fate of LINE-1 retrotransposition. In addition, EpiPluriRetro will analyze the impact of LINE-1 insertions in our pluripotent genome and the Epimutagenic impact of new LINE-1 mobilization events in pluripotent cells. To do that, we have developed an innovative approach to analyze the effect of LINE-1 insertions within human genes without biases, including epigenetic alterations induced by a new L1 insertion. EpiPluriRetro will help to understand how the activity of TEs is controlled in our heritable genome, which will directly impact our knowledge in how new genetic diseases are generated in humans. In addition,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Miniaturised Hall effect propulsion for small satellites'.

assistant: **Concept**

The space industry is rapidly evolving from a world where bus-sized satellites are being developed during years and for more than 200M$ towards a world where shoebox-sized satellites are being designed, built and launch for less than 1M$ and in less than a year. Constellations of these small satellites are delivering services in Earth observation and telecommunication. Due to this revolution, the small satellite market is growing at 20% per annum – 2.9Bn$ in 2017, 7.5Bn$ in 2022.  However, these constellations suffer from a great lack of agility. Propulsion systems were poorly or not miniaturised, causing small satellites to be unable to change their orbit after launch. This induces high launch costs, no choice of the operational altitude and poor performances.   Exotrail’s vision is to provide and sell this agility to the space industry. The first way we do this is by providing an affordable and efficient propulsion system for constellation of small satellites along with a set of software add-ons to design, optimise and operate propulsion manoeuvres. With electric propulsion, our customers can double their picture resolution, divide by two their launch costs, increase their telecommunication coverage and multiply their lifespan by a factor up to 20. Our miniaturised thruster using Hall effect technology minimises the power consumption compared to competing solutions. Because of this, we are able to greatly reduce the total cost of using propulsion for our customers. These competitive advantages have created strong customer interest for Exotrail including two letters of intent. Our thruster will be ready for the market in 2019.  Our ambition is to become a global provider of agility by selling inspection, delivery and assembly services thanks to a fleet of light and agi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Personnel Location and Tracking for Safety, Security and Protection' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The global indoor location market is expected to grow 23.13 Billion USD by 2021, at a Compound Annual Growth Rate of 37.4%. Although attractive, in the market there is a sound evidence of a still unsatisfied offer of a location system in GPS-denied environments for safety, security and protection for time/risk-critical operations. DUNE introduces PROTECT (4 patents filed): a new, autonomous, infrastructure-free, wearable tracking system for GPS-denied environments. Major PROTECT advantages w.r.t. competitors: no need of ad-hoc deployed infrastructures, floorplans, calibrations and pocketsize. The three major guidelines of PROTECT are: 1) value proposition: provide a high perceived value for the customers by a localisation system: a. generating advantages (performance): location accuracy for both real-time, time-critical operations and post survey analysis (e.g. inspectors of nuclear plants); b. decreasing difficulties (suitability): infrastructure-free and 'switch and forget' system, suitable for the operations in real scenarios, so to be acceptable by the end-users with zero impact on their practices; 2) affordability: make the system affordable, with a business plan ranging from SaaS to licensing, always keeping the unitary cost below the expenditures capabilities of the clients, also minimising their OPEX; 3) profitability: make the system profitable, by adopting a modular/layered approach, so to accommodate a large ensemble of requirements, coming from different customers, thus minimising the CAPEX on our side. The main goals of the project are:  a) acquire a leading position in the localisation market for first responders and CIs;  b) a turnover of 24 M€ within the end of the 3rd year; c) the break-even for commercialisation at end of the 1st year; d) an increase o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New Induction Wireless Manufacturing Efficient Process for Energy Intensive Industries' (NIWE).

assistant: **Innovation**

NIWE project will demonstrate a new production process able to decrease the embodied energy of the foundry products by over 25%, reducing drastically its carbon footprint. The demonstration will be performed in the aluminium, iron and steel sectors.The expected energy efficiency gains are due to a new furnace that, by means of a power transmission system based on induction, will allow a highly flexible production. This increase on the production flexibility attends to the current variability of the foundry products demand.The current crisis has introduced a high variability in the demand, which can be measured in terms of quantity and diversity of the demanded products. The manufacturers are now forced to start and stop many times their production chains, change the moulds and, the most important in energy penalty terms, to reheat many times big quantities of raw materials. Consequently, the cost efficiency of the process has suffered a high decrease.NIWE tackles these actual and current problems by providing a new furnace that will take the power by an inductive coupling. This will provide a very quick power transmission from the grid to the furnace. This power will be supplied to the heating system, which, depending on the foundry material could consist on resistances or induction heating.The rapidity of the power transmission system, as well as the wireless operation, will allow the use of smaller furnaces. This way, the reserve of melted material for feeding the moulds will be smaller, and therefore the required energy to maintain it melted.In addition, the wireless furnace will provide a flexible operation, allowing a quick modification of the factory layout, which will be based on easy interchangeable furnaces of different types andsizes, depending on the demand.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Dynamic Abatement Strategies for maximized environmental and societal health in cities' (PUREPOLIS), addressing dissemination and exploitation.

assistant: **Impact**

Each year, pollution claims thousands of lives across Europe, yet city administrations struggle with limited resources and the need to balance the multiple and uncertain effects of potential solutions. PUREPOLIS is set to transform urban health by pioneering advanced tools that empower policymakers to take high-impact action.At its core, PUREPOLIS drives data-driven, citizen-powered, and science-backed decision-making. A breakthrough Citizen Science Application (PR1) will enhance engagement and real-time monitoring. The Near Real-Time Pollution Source Apportionment tool (PR2) and Risk-based Health Impact Assessment framework coupling epidemiology and toxicology approaches (PR3) will precisely link exposure to 35 pollutants and their combination across air, noise, water, and soil to 10 critical health risks, including wellbeing.To maximize the efficiency of Zero Pollution Measures, PUREPOLIS will deploy cutting-edge analysis (PR6) to assess their effectiveness in terms of health, economic, and climate impacts, embracing a complexity perspective. These insights will feed into a Dynamic Abatement Strategies Toolbox (PR7), ensuring seamless policy integration into co-created, tailored comprehensive strategy for each of the two case studies in France and Spain, optimising co-benefits with multiple policy sectors.PUREPOLIS also pioneers a Vulnerability framework (PR4) and Behaviour framework (PR5) to drive behavioural changes for more successful interventions and foster equitable and sustainable solutions. Beyond core cities in France and Spain, a next-gen Digital Twin (PR8) and policy reports (PR9) will ensure replicability, scalability, and real-world impact across Europe.With nineteen partners from eight countries over thirty-six months, PUREPOLIS is an unprecedented step
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Visualizing the molecular control of blood - stroma interactions at the single cell level' (VB-SINT) under Sixth Framework.

assistant: **Objectives**

The behaviour of hematopoietic cells is influenced by their microenvironment. These niches" are composed of variety of cells, including stromal cells. As cells mature, they move from one niche to another within the bone marrow until they are released into the periphery. To further understand these interactions, we will utilize a novel, non-invasive computer-driven microscopy program to visualize the interaction of blood cells with stromal cells at the single cell level.Stromal cells lines have been previously generated from fetal liver and one such cell line has been shown to support primitive blood cells. We will directly compare the interaction of immature and mature blood cells on this stromal cell line and other stromal cell lines that d o not maintain immature blood cells. By doing this, we hope to understand how hematopoietic cells behave on these cells and what interactions occur to keep blood cells immature, or how they are induced to mature.To further understand the factors involved in the interaction of blood cells with different niches, we will introduce the expression of growth factors into stromal cells and assess their effect on hematopoietic differentiation and movement. We will also eliminate the expression of growth factors to find out the effect of the loss of these proteins on blood cell behaviour."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The effects of agronomic practices conducive to organic agriculture on the diversity and function of arbuscular mycorrhizal fungi' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Arbuscular mycorrhizal fungi (AMF) extensively form symbiotic relations with most plants which in most cases result in benefits to the plant including improved nutrition, amelioration of drought stress, improved soil structure, and protection from soil pathogens. AMF are considered key microbial players in low-input agricultural systems like organic farms. Selected efficient AMF could be used as soil inoculum in organic agriculture to benefit plant growth. Crop protection in such organic farms relies on pesticides of biological origin like azadirachtin or Quillaja saponaria, the use of non-chemical soil disinfection methods like soil solarization or biofumigation. The application of by-products of local agricultural industry like olive mill wastewaters (OMWs) might suppress soil plant pathogens and/or improve soil fertility. Although all the above practices are conducive or already used in organic farms there are no data regarding their effects on AMF and fungal community. The current proposal aims to investigate possible effects of crop protection and fertilization practices, conducive to organic farming fundamentals on the community and activity of AMF and other soil fungi. An initial survey will investigate the AMF status, diversity and function in organic farms. Selected AMF from the initial survey will be propagated at pure cultures and community cultures in order to be used in further experiments. Subsequent pot experiments will provide initial evidence of possible effects of the previously mentioned agronomic practices on the function and activity of AMF and fungi. Pot experiment results will be verified at replicated field experiments which allow the evaluation of the effects of these practices under realistic conditions. The proposed project will facilitate the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovative tools and strategies for surveillance and control of dengue' (DengueTools).

assistant: **Innovation**

Current surveillance systems and control efforts are clearly insufficient to combat dengue in endemic countries and to prevent spread to previously uninfected areas (including Europe). We will focus on the following aspects of the call: better diagnosis, surveillance, prevention as well as prediction and/or prevention of the spread of Dengue fever to previously uninfected regions (including Europe) in the context of climate change. We will develop a rapid diagnostic assay for resource limited settings that can be used as point-of-care, is portable, provides rapid results and is inexpensive.  Novel tools for vector monitoring will be tested. We propose to develop a comprehensive,  early warning, laboratory-based sentinel surveillance system that integrates clinical, entomological, environmental, socio-economic,  and weather/climate indices to evaluate predictive capability for epidemic dengue. The aim is to translate this information directly into improved tools for surveillance (early diagnostic assays, early warning systems and predictive models, risk maps, improved tools for vector surveillance).  Furthermore, we will test the impact of a novel community-based strategy on the reduction of dengue incidence in school aged children. Lastly, the integrated information on trends of importation of dengue, global mobility patterns, and vector distribution under changing climate conditions will improve our current understanding of the risk of introduction into previously uninfected areas, in particular Europe. Web based predictive tools, models and maps will be produced. The information will be disseminated to relevant agencies, academia and policy makers and will translate into improved surveillance and control.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unravelling complex diseases with complexity theory: from networks to the bedside' (COMPLEXDIS).

assistant: **Concept**

Common diseases like allergy, autoimmunity and cancer are complex, i.e. caused by multiple interacting genes and environmental factors. Using high-throughput methods all genes and their products can be studied in common diseases. The challenge lies in understanding the complex gene and protein interactions that underlie these diseases. The Pathfinder project has shown that common principles, such as network theory can be used to understand widely different complex systems. Despite this there have been few applications in medical research.The hypothesis behind this project is that complexity theory can be used to unravel disease mechanisms and to develop predictive models of complex disease. The models will be validated experimentally and by solving a real-world clinical problem, i.e. to find biological markers for personalized medication. This involves the design, implementation and enhancement of complexity tools (e.g. network theory metrics) used to assess emergent properties from experimental studies of complex diseases, such as allergy, autoimmunity and cancer.Network theory plays a central role in our approach through the use of separators, connectivity, covers and cliques. Complex diseases are seen from a systems perspective and the focus is on the emergent properties of systems rather than individual components. This involves transfer of knowledge from complexity studies in other fields, such as language evolution. An important feature of the project is that it aims to transfer and develop techniques from complexity science to solve a real-world problem, i.e. to find markers for personalized medication in two different diseases, i.e. allergy and multiple sclerosis.We believe that this can be achieved within a three-year period and used to promote the science of c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Tunable Radiation Tolerant 2D Terahertz  bolometer' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

THz fingerprints of space objects are of a great value as they provide the insights into history of the Universe, formation and evolution of galaxies and their central supermassive black holes, and other fundamental problems of astrophysics. The primary scientific goal of TURANDOT is to combine advantages of graphene and transition metals dichalcogenides monolayers to pave the way towards new generation of THz detectors for space application showing beyond the state-of-the-art KPIs and having unprecedented tunability and remarkable radiation tolerance. Through multidisciplinary approach based upon ER’s expertise in elementary particles, quantum physics and electromagnetics, and the host organization outstanding expertise in material science, nanotechnology and photonics TURANDOT aims at designing a prototype of Tunable  Radiation  Tolerant  2D  Terahertz bolometer, approaching technology readiness level 3 in breakthrough THz space technology. Implementation of this ambitious project will enhance the ER creative and innovative potential and will help to diversify her individual competence in terms of skill acquisition through advanced research and innovations training, and international mobility. Results to be obtained upon completion of the MSCA IF will enable submission of an Advanced European Research Council proposal with ER as a principal investigator and University of Eastern Finland as the host organization.