RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Avodes - biotechnological menstrual product for Candidiasis prevention' under Horizon Europe.

assistant: **Concept**

372 million women globally have a silent torturer - recurrent vulvovaginal candidiasis (VVC) , which affects 3 out of 4 women at some point in their lives. Despite therapeutic advances, VVC remains a common problem worldwide, affecting all strata of society and being the second largest gynaecological infection. If it is left untreated, many complications have been appointed as its consequence, such as infertility, subsequent preterm delivery, suppression of the immune system, pelvic inflammatory disease, ectopic pregnancy, pelvic abscess, menstrual disorders and miscarriage.Avodes has developed an innovative medical device for menstruation - a patented anatomically shaped “moist sponge” made of completely natural, biodegradable materials (biodegradable within 1 month). It protects innate defence mechanisms of vaginal microflora during most vulnerable period – menstruation. Studies have shown, that fluctuating hormones and the resulting imbalance of vaginal flora cause an increased risk of a yeast infection every month. Unique Avodes biotechnological solution preserves women’s natural vaginal microbiota in the same time selectively inhibiting growth of pathogenic microorganisms. It reduces risk of vulvovaginal candidiasis (VVC) by 85 % thus effectively preventing the disease. Avodes is the only medical product designed to prevent infection, rather than deal with the consequences. Avodes effectively disrupts the vicious cycle of ”microbiota disbalance –> infection –> antibiotic/fungicidal treatment–> microbiota disbalance” and offers break-through solution which protects women’s health and the environment.  Women Tech EU programme would support company in upgrading the business model, business and marketing plan, market validation and would help to find partners (clinical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'High-throughput Epigenetic Regulatory Organisation In Chromatin' to be submitted under Sixth Framework.

assistant: **Abstract**

The completed genetic code of many organisms gives science the chance at last to understand how genes build organisms. Unfortunately, like all truly great codes simply decoding the letters does not explain how life is manifest since buried deep in the primary genetic code is a second regulatory code that we need to decipher to understand how the genome works. This regulatory code is encrypted in chromatin and 3D nuclear organization and functions to regulate accessibility of the primary genetic information. We know that there is linear genome organization and that genes subject to similar regulatory controls are adjacent to each other. What we do not yet know is the extent of these 'genome domains' if domains operate between different chromosomes, or, how domains are set up and maintained. Answers to these questions will depend upon global and long-range genome strategies that need the development of high throughput technologies. HEROIC will take a two-pronged approach. First, HEROIC will develop global biochemical and high throughput genomic tools and screens that will identify novel gene regulators and determine when and where transcription factors, histone modifying enzymes and chromatin remodeling proteins, interact with the primary genetic code. Second, well-characterized progenitor-differentiation systems such as pluripotent mouse ES cells and paradigm silencing models from genomic imprinting and X inactivation will be studied using high throughput ChIP-on-chip, chromosome interaction and whole genome nuclear localization assays to provide basic information on linear and 3D genome organization. HEROIC will provide knowledge that contributes to a functional understanding of gene regulation in a genome context. It will inject epigenetic research with high throughput
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Developing of efficient and fossil free fire test methods and assessment protocols for the fire resistance of construction elements.' (4FM), addressing dissemination and exploitation.

assistant: **Impact**

The Marie Skłodowska-Curie Actions  Green Charter guides all the researchers and the academic community to work towards a greener and better future. Therefore, the current action is appropriate and timely as it is primarily dependent on the reduction of the excessive amount of carbon footprints, generated through the huge number of fossil-based experiments conducted to observe the suitability of structural materials for different applications and denoting fire-ratings. The project will focus on introducing fossil-free electric heating (inductive/resistive) for different structural materials and compare the results to the established fossil-based ones. The aim being to prove that fossil-free methods can also help in providing the required information on different structural materials, resulting in possible standardisation of the same. Acceptance and proper functioning of the method will substantially help in reducing the use of fossils, specifically propane, and in working towards a more sustainable environment. Furthermore, the process will also enable in providing a portable and economical way for research institutes and universities to conduct large-scale experiments on new structural materials. The action will also involve the specification of a method to achieve optimal desired fire-safety in materials, and a renewable wood-based structural composite material that has good mechanical and fire performances. The successful preparation, testing and analysis of the new structural material will further enable the team to file a patent. Additionally, the same material will be used to prepare corrugated and honeycomb sandwiched structures with numerical modelling, that for the first time will capture the influence of the cell sizes on the flammability of the structure.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Efficient refrigerated food storage' (EFROST) under Sixth Framework.

assistant: **Objectives**

The aim of this project is to improve the energy efficiency of food cold stores considering environmental protection and food safety/quality issues. The project approach is based on the systematic application of advanced numerical and experimental techniques, taking also into consideration economical criteria.The first project period (16 months) focus the attention on the main elements of the unit:i) chamber ventilation control and management (air throw, frosting-fan, lay-out);ii) minimisation of heat an d humidity gains (insulation, infiltrations, frosting-defrosting);iii) ammonia refrigeration systems (refrigeration cycle, in-tube evaporation data, low-charge concepts);iv) indirect ammonia refrigeration systems with more efficient secondary coolant loop s (ice-slurries, single-phase coolants).All these tasks are performed in parallel but conveniently coupled through the common element: the air-cooler. Based on the developed infrastructures and the acquired know-how during the first period, an advanced rating and design software tool for the analysis of the whole cold-storage unit (chamber, air-cooler, refrigeration system) will be created. The code will be accessible via web. It will take advantage of parallelisation techniques on Beowulf PC clusters.A set of test cases representative of the layouts usually found in real-life installations will be performed using this code and the guidelines developed. During this second period (last 8 months), special attention is paid to provide adequate up-to-date dissemination procedures to get the best profit from project simulation and experimentation results/software/guidelines. Management tasks will be mainly focussed on the co-ordination of the tasks interdependence, very relevant in this project because of the multidisciplin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Identification and characterization of enteric nervous system stem cells'.

assistant: **Objectives**

The digestive system is essential for water and nutrient uptake, waste removal and serves as a sensory system providing information to the central nervous system via the gut-brain communication axis. The gastrointestinal tract harbours the largest collection of neurons and glial cells collectively known as the enteric nervous system (ENS) and regulate digestive physiology independently of brain input. Intestinal function and homeostasis depend on the integrated and balanced activity of multiple gut tissues,in which, the ENS plays a critical role by actively interacting with the intestinal immune system, the epithelial barrier and microbiota. Developmental deficits or acquired disorders in any of these tissue components can result in debilitating gastrointestinal conditions, such as Hirschsprung disease (congenital megacolon) or inflammatory bowel disease. Despite critical contributions of the ENS to digestive physiology and intestinal homeostasis, very little is known about the cellular mechanisms that underpin its function at steady state conditions or in response to injury. IDENSTEM will address the identity and properties of ENS neural stem cells (ENSCs) using the mouse as an experimental model organism. Preliminary data suggest that a subpopulation of enteric glial cells expressing the Notch signalling target Hes5, undergo low rate proliferation and exhibit neurogenic potential. In this proposal, we aim to identify and characterize the cellular and molecular properties of this population. We wish to understand their contribution in maintaining ENS integrity under normal conditions or in response to injury/disease. These studies will advance fundamental neurogastroenterology and the development of novel therapeutic strategies for various gut disorders. Furthermore, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Protective and pathogenic immunological memory and its organisation by stroma cells' under Seventh Framework.

assistant: **Concept**

Immunological memory provides immunity against recurrent pathogens, but also can induce and regulate immunopathology. In chronic immune-mediated diseases, a ""pathogenic"" immunological memory probably is the essential driver of inflammation, refractory to physiological regulation and state-of-the-art therapeutic immunosuppression, and thus a challenge for the development of novel, curative therapeutic strategies. Despite its relevance, immunological memory is poorly understood. We recently discovered memory plasma cells and professional memory T helper cells, and their organisation by bone marrow stroma and the stroma of inflamed tissues. We have identified genes and regulating function and persistence of memory and effector cells in the resting state and in chronic immune reactions. Based on these intriguing, paradigm-breaking initial results, I propose to develop and lead a research program addressing the organisation and role of immunological memory in protective immunity and in immune-mediated diseases, on the systemic, cellular and molecular level. In particular, I propose to (1) analyse the homing of plasmablasts and T helper memory cell precursors to dedicated survival niches of the bone marrow or inflamed tissues, (2) identify the niches of CD8 memory cells and memory B cells, (3) analyse the cellular and molecular composition of memory niches, (4) decipher the molecular communication between stromal cells and immune memory cells, (5) analyse how memory/effector T helper cells are reactivated, (6) define the role of memory-phenotype T  cells in the periphery, (7) analyse the role of twist1 and hop  for persistence and function of pathogenic Th memory/effector cells, and (8) develop strategies to selectively delete pathogenic immune memory cells.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'NBIA INTERACTIONS POSTDOCTORAL PROGRAMME'.

assistant: **Objectives**

The Niels Bohr International Academy (NBIA) is a permanent research centre within University of Copenhagen. It functions as a primary venue for basic research in theoretical and mathematical physics, including the model description of physical systems and data. Constantly focusing on new developments, the NBIA spearheads the introduction of new research areas by attracting international, high-profiled young scientists working on brand-new topics. NBIA provides the unrestricted intellectual environment essential to enable curiosity-driven, breakthrough research by fostering a cross-disciplinary scientific culture. To this end, the NBIA endeavours to attract to Denmark the best and brightest international talent from all over the world, with total commitment to selecting the very best candidates, regardless of race, religion or gender. INTERACTIONS supports the ambitious goal of the NBIA is to become the leading European institution of its kind.    The idea behind the Niels Bohr International Academy is a throwback to the days when scientific breakthroughs resulted from close interactions between people driven by their own curiosity.   INTERACTIONS: With this application for an ambitious EU-supported programme called INTERACTIONS we aim to use the NBIA as a platform to enhance the internationalization and cross-fertilization among different subjects within theoretical physics and associated sciences for the benefit of Europe. Through this programme we will train some of the brightest theoretical physicists available from all over the world. We provide  •Exceptional opportunities to interact and collaborate with top international research environments•Opportunities to develop independent research projects and create independent research groups  •Employment under world lead
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Transparent, Reliable and Unbiased Smart Tool for AI' (TRUST-AI) under Horizon 2020.

assistant: **Objectives**

Artificial intelligence is single-handedly changing decision-making at different levels and sectors in often unpredictable and uncontrolled ways. Due to their black-box nature, existing models are difficult to interpret, and hence trust. Explainable AI is an emergent field, but, to ensure no loss of predictive power, many of the proposed approaches just build local explanators on top of powerful black-box models. To change this paradigm and create an equally powerful, yet fully explainable model, we need to be able to learn its structure. However, searching for both structure and parameters is extremely challenging. Moreover, there is the risk that the necessary variables and operators are not provided to the algorithm, which leads to more complex and less general models.It is clear that state-of-the-art, yet practical, real-world solutions cannot come only from the computer science world. Our approach therefore consists in involving human intelligence in the discovery process, resulting in AI and humans working in concert to find better solutions (i.e. models that are effective, comprehensible and generalisable). This is made possible by employing ‘explainable-by-design’ symbolic models and learning algorithms, and by adopting a human-centric, ‘guided empirical’ learning process that integrates cognition, machine learning and human-machine interaction, ultimately resulting in a Transparent, Reliable and Unbiased Smart Tool.This proposal aims to design TRUST, ensure its adequacy to tackle predictive and prescriptive problems, and create an innovation ecosystem around it, whereby academia and companies can further exploit it, independently or in collaboration. The proposed ‘human-guided symbolic learning’ should be the next ‘go-to paradigm’ for a wide range of sectors, w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integrated approach to solar control techniques' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Project Objectives The project is aimed at providing tools and validated data on building shading devices and control to the building profession and final users. New algorithms describing the behaviour of the shading devices in respect to solar radiation, visible radiation and ventilation will be developed, validated and integrated in existing simulation tools. New 'smart' solar control systems for integration into the building envelope will be developed, with special emphasis on their impact on energy consumption and improvement of the indoor comfort. Finally, design guidelines and a shading component Handbook will be produced for European architects and building designers. Technical Approach The optical characterisation of the selected shading devices (external, interpane and internal, homogeneous and non homogeneous) will be carried out, by means of an outdoor integrating device mounted on a 2-axis tracking bench and by spectrophotometer techniques. For the thermal characterisation, different techniques based on calibrated hot-box apparatus, solar caloriplate, test cell experiments and validated models will be applied and compared. Daylighting experiments aimed at the determination of daylighting factors and internal luminance distribution will be performed inside a full scale mock up office and in Test cells. The impact of the shading devices on the ventilation of building spaces will be tested on the Test cells by measuring the air change per hour ( Tracer Gas Techniques ) and the wind velocity field before and after the shading ( Hot wire sensors ). The smart solar control system will be identified by modelling, building simulation tools and control simulator subroutines. The implemented solar control assembly will be tested inside Test cells in different climates
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Matrix Models Recursions in Topological Strings and Beyond' (MMRTSB) under Seventh Framework.

assistant: **Objectives**

Recently it has appeared that recursions relations formulated in the context of matrix models can be applied to solve a wide array of problems ranging from topological string theory to algebraic geometry to statistical physics. It has also been shown that matrix models recursions are sometimes equivalent to other known recursions developed to solve several algebro--geometric problems. Matching recursions belonging to different areas has very deep conceptual implications pointing to the existence of some hidden universal property of solvable problems which would explain the broad applicability of matrix model technologies. In this research project several problems will be addressed with these new tools, from mostly mathematical to more physical ones. On the more formal side matrix models technologies will be employed in topological strings and algebraic geometry, fields where the profitability of these methods is by now well established. On the physics side more explorative researches will be carried out mostly in the context of the AdS/CFT duality and in the computation of gluon scattering amplitudes. This interdisciplinary project is expected to be a means for knowledge transfer between the mathematics and string theory communities. The training proposed in this project aims at enhancing all aspects of the applicant's capability to perform leading independent research.