RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'RAM is a revolutionary magneto-optical technology platform, outperforming current solutions in accuracy, cost, and time to diagnosis, when assessing human blood cells for Malaria presence' in the context of a Horizon 2020 call.

assistant: **Objectives**

Malaria as a disease has long-since continued to drain the finances, and resources of European entities, and everyone else involved, when trying to contain its negative effects. Most pressing of all, are the millions of innocents lives lost to the disease, with numbers continuing to climb every minute. The Rapid Assessment Malaria (RAM) serves to be the first malaria screening tool, that is able to quantify even the slightest presence of malaria parasites in an individual's blood cells, regardless of symptoms, all within the space of 60 seconds. The device exceeds all competitor offerings on the 6 key metrics defined by the World Health Organization as being pivotal to being a malaria detecting tool; with the top of the list being sensitivity to density of infection. The objective is to optimize the beta prototype in its magnetic and lighting technical functionalities, in order to obtain the most accurate number of malaria parasites when assessing blood cells.This will be achieved through continual engineering of current electronics, in conjunction with third-party optical experts, to fine-tune the current prototype in order to be conclusively showcased in clinical trials. Progress with the WHO and major private entities such as Bosch healthcare have already been established ensuring a ready-made sales channel upon European commercialization. The proposed work in Phase 1 of the SME instrument fits into the overall plan to reach market by contributing the financial resources needed to plan a fast sound wider deployment of the RAM solution and its market uptake, specifically in its current dealings with large healthcare organisations as both distributors and end-users of the product.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'BIOMOLECULAR CHARACTERIZATION OF STREPTOMYCES DIFFERENTIATION AND ITS RELATIONSHIP WITH SECONDARY METABOLITE PRODUCTION' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Streptomyces is a gram positive bacterium characterized by a complex developmental cycle. It is considered as a multicellular prokaryotic model that includes programmed cell death and sporulation. Streptomycetes are very important in industry, since they produce two thirds of clinically relevant secondary metabolites. Streptomyces and other bacteria with complex life cycles represent the evolutionary origin of some of the protein domains involved in the most important eukaryotic signalling pathways.The classical Streptomyces developmental cycle focused in the sporulation. Industrial fermentations are mainly produced in liquid cultures (large bioreactors), conditions in which there is not sporulation, and it was traditionally considered that there was no differentiation. During his predoctoral training, A. Manteca re-evaluated Streptomyces development in solid sporulating cultures, laying the foundation of a new research line about Streptomyces differentiation totally independent to the investigations of his PhD supervisor (Streptomyces nucleases). During his postdoctoral training, he continued working in this emerging research line analyzing the relation between differentiation and secondary metabolite production, reporting the first study in which antibiotic production could be associated with hyphae differentiation in liquid. Later, he focused in the proteomic analysis of Streptomyces differentiation, creating the most complete database about proteome variations associated with hyphae differentiation.The main objective of this project will be characterizing the biomolecular pathways behind Streptomyces differentiation, and their homologies and differences with eukaryotic signalling pathways. We will use the innovative developmental model elaborated by us and the infor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Addressing inequality, enhancing diversity and facilitating greater dialogue in the hosting of sporting mega events.' (EventRights), addressing dissemination and exploitation.

assistant: **Impact**

Major sporting events (MSEs) have been the subject of increasing levels of critique in recent years for the social costs associated with their bidding, planning and delivery. The rationale used by cities and countries for hosting MSEs is often the potential for an event to generate positive economic and social transformation within the host area (Brittain, Bocarro, Byers and Swart, 2017). However, research has repeatedly demonstrated actual impacts of hosting MSEs fall short of these lofty claims and in reality often result in detrimental effects for host populations. The negative impacts of MSEs have variously been reported as: exacerbating human rights abuses; facilitating corruption; supporting elite beneficiaries over those most in need; and transforming host destinations’ urban environment by displacing vulnerable populations. Recent mega sport events (a specific category of the largest MSEs, such as the Olympic Games and World Cup; Muller, 2015) have been the subject of international condemnation for being the catalyst for forced evictions (Beijing 2008; Rio de Janeiro, 2016), restricting media freedom through censorship (Sochi, 2014), abuse of migrant labour in the construction of facilities (Sochi, 2014; Qatar, 2022) and increased political repression (Beijing, 2008). Human Rights Watch has suggested that “Time after time, Olympic hosts have gotten away with abusing workers building stadiums, and with crushing critics and media who try to report about abuses…the right to host the Olympics needs to come with the responsibility not to abuse basic human rights”  (Minky Worden, Director of Global Initiatives, HRW). The EventRights project will explore and produce recommendations as to how MSEs can influence MSE organizing committees and other stakeholders to ensure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structure and dynamics of intermediate states in protein folding' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Young postdoctoral researchers will be given the opportunity to apply all countries, cooperating to study the intriguing, but elusive mechanism of the available techniques to the particular protein, or class of proteins, protein folding. Two of the groups have a strong background in that was assigned to them. We foresee that at least some of these trainees computational biophysics, the remaining groups are equipped to do will actually perform part of their research in other laboratories within experimental work on various proteins. The combined expertise includes the network. They will be trained, not only to apply these techniques, but also to cooperate closely with theoreticians, working on the same protein, important techniques like NMR and mass spectrometry, as well as stopped flow spectroscopy, calorimetry, and molecular biology, peptide synthesis to formulate testable models of protein folding and to perform protein engineering. From the theoretical point of view we envisage an evaluate such tests. On the other hand, theoreticians will be trained in important role for molecular dynamics calculations in combination with the producing testable models wherever possible, and to accommodate the results essential dynamics analysis. of such tests in an improved model. They will be encouraged to participate The primary issue will be the identification, by theoretical and in network research meetings, network discussions (possibly via the experimental means, of nucleation centres, where protein folding is Internet), as well as the regular summer schools, master classes, and initiated, and of folding intermediates, followed by their structural and international conferences. kinetic characterisation. Where possible stable nucleation centres and folding intermediates will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Unveiling the true historical and biological origins of key phenotypes in modern domestic horses'.

assistant: **Innovation**

The horse provided humankind with the ability to travel well above its own speed and changed the face of warfare, and the geographic expansion of people, languages and culture. As such, the domestication of the horse some 5,500 years ago represents not less than a turning point in human history. While domestication shaped a great diversity of horse phenotypes, fit for a wealth of human purpose, many of the underlying causative genetic variants, and the geographic and temporal locus of their associated native breeding centers remain unclear. The HOPE project is aimed at the identification and functional validation of genetic innovations that have accompanied the birth and spread of important phenotypic traits during the history of modern domestic horses. Our methodology will leverage state-of-the-art methodologies in two complementary research fields, each synergizing the core expertise of the supervising host and postdoctoral fellow. These will first consist of using the ancient DNA and population genomics toolkits for shortlisting genomic variants candidates for driving important phenotypic features, and second harnessing the full power of functional genomics to measure some of their biological mechanism in cellular. The HOPE project will, thus, fill an important gap in our knowledge of horse evolution and will mark the birth of a new era in archeo-genomics, moving away from the sole description of putative adaptive markers, currently limiting most common studies, to the investigation of the conformational, performance, physiological and medical in living animals.


**Keywords:** Ancient DNA,  Horse Domestication,  Phenotype Evolution,  Functional validation,  Biological mechanism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Critical fluctuations for spin dynamics' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

In previous works we understood the microscopic derivation of a family of Non-Linear Stochastic Equations (NLSE), by analyzing two different kinds of one-dimensional spin models . We proved that the critical fluctuations" of the "magnetization density field" converge to the solutions of these kinds of NLSE. These NLSE have applications in the theory of critical phenomena (as is evident also from the models) and problems concerning stochastic quantization. The invariant measures of these NLSE are the P( ) Euclidean Fields. The interesting problems concerning this topic are in space -dimension 2. For one of these two models analyzed in the previous works we might have good possibilities to extend the results in 2-space dimensions. This model evolves with a reversible "Glauber dynamics" with respect to a Gibbs measure defined by a "Kac potential". Recent results obtained by Cassandro M., Marra R., Presutti E. concerning the invariant measure in 2 dimensions let us think that we should succeed in analyzing the dynamics of the 2-dimensional critical fluctuations. Difficulties arize because of ultra-violet divergencies "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'TSO-DSO-Consumer INTERFACE aRchitecture to provide innovative grid services for an efficient power system', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

With the growth of renewables, the increased interconnection of European grids, the development of local energy initiatives, and the specific requirements on TSO – DSO cooperation as set forth in the different Network Codes and Guidelines, TSOs and DSOs face new challenges that will require greater coordination. The European Commission adopted legislative proposals on the energy market that promote cooperation among network operators as they procure balancing, congestion management and ancillary services. The measures encourage procurement of services at both the transmission and distribution level, recognizing that this will enable more efficient and effective network management, will increase the level of demand response and the capacity of renewable generation. TSOs and DSOs must now define the services they want to procure in collaboration with market participants, and must set up ways to procure them in a coordinated manner. Digitalisation is a key driver for coordination and active system management in the electricity grid, enabling TSOs and DSOs to optimise the use of distributed resources and ensure a cost-effective and secure supply of electricity but also empowers end-users to become active market participants, supporting self-generation and providing demand flexibility. To support the transformation, the INTERRFACE project will design, develop and exploit an Interoperable pan-European Grid Services Architecture to act as the interface between the power system (TSO and DSO) and the customers and allow the seamless and coordinated operation of all stakeholders to use and procure common services. State-of-the-art digital tools based on blockchains and big data management will provide new opportunities for electricity market participation and thus engage consumer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Whole Earth Systems During Neoproterozoic Animal Evolution' (NEOEARTH).

assistant: **Innovation**

The late Neoproterozoic Era marks some of the most important changes in the biogeochemical evolution of our planet. During the late Cryogenian,Ediacaran and Early Cambrian Periods (ca. 650–520 Ma), our planet was marked by a global icehouse event (‘Snowball Earth’), a rapid rise in oxygen content of the atmosphere, evolution of animals and complex life forms and the amalgamation of the Gondwanian supercontinent, which formed the earliest ‘modern’ style mountain belts with the deep burial of continental crust resulting from massive continental-continental collisions. So far, biogeochemical modelling, geochemical analysis and general circulation climate models (GCMs) have linked all these key events to plate tectonic processes. However, there is yet to be a fully complete linked tectonic-biogeochemical-climate model, where geologically grounded parameters are passed directly into both biogeochemical and GCMs, principally because there is no full tectonic model of this time. Recent advancements in plate tectonic modelling have produced models that map the explicit kinematic evolution of plate boundaries and tectonic plates back to 1 Ga. Using this model as a foundation, I propose to construct secondary tectonic parameters (palaeobathymetry, palaeotopography, carbon flux) of the world between 650 and 520 Ma in order to act as a series of boundary conditions for a GCM and biogeochemical model. The GCM is constructed using the surface conditions from the tectonic parameters (palaeobathymetry, palaeotopography, continental positions) to produce surface temperature and hydrological estimates at key time intervals. These estimates, along with carbon flux estimates—calculated using the same plate model—are used to derive self-consistent biogeochemical cycles (e.g. O2, CO2, P cycl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Programmed and unprogrammed genomic rearrangements during the evolution of yeast species'.

assistant: **Objectives**

By detailed evolutionary comparisons among multiple sequenced yeast genomes, we have identified several unusual regions where our preliminary evidence suggests that previously unknown molecular biology phenomena, involving rearrangement of genomic DNA, are occurring. I now propose to use a combination of dry-lab and wet-lab experimental approaches to characterize these regions and phenomena further. One region is a 24-kb section of chromosome XIV that appears to undergo recurrent 'flip/flop' inversion between two isomers at a fairly high rate in five species as diverse as Saccharomyces cerevisiae and Naumovia castellii, leading to a 1:1 ratio of the two isomers in each species. We hypothesize that this region is the site of a programmed DNA rearrangement analogous to mating-type switching. We have also identified two new genes related to the mating-type switching endonuclease HO, but different from it, that are potentially involved in rearrangement processes though not necessarily the inversion described above. We will determine the sites of action of these endonucleases. Separately, we have found evidence for a process of recurrent deletion of DNA from regions flanking the mating-type (MAT) locus in all yeast species that are descended from the whole-genome duplication (WGD) event, causing continual transpositions of genes from beside MAT to other locations in the genome. In related computational work, we propose to investigate an hypothesis that evolutionary loss of the MATa2 transcriptional activator may have been the cause of the WGD event.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovation Relay Centre in the 5 regions of Great Eastern France (Alsace, Bourgogne, Champagne-Ardenne, Franche-Comté, Lorraine)' (2002-2006) under Sixth Framework.

assistant: **Objectives**

The IRC Grand Est" project is composed of the two current (FP 5) IRC Centr'Est and IRC Alsace-Lorraine. The new IRC Grand Est will cover the five regions of Great Eastern France (Alsace, Bourgogne, Champagne-Ardenne, Franche-Comté, Lorraine). The new IRC is thus gathering the experience of both IRCs. Furthermore, the newly proposed geographical coverage fits better with the policy of the 5 concerned Regional Authorities which have decided to work jointly in the "Grand Est" area on several economical matter s. The IRC will provide services to the local industry with an emphasis towards SMEs in order to promote and facilitate transnational transfer of technologies and knowledge, to disseminate and exploit the results of EC research by third parties, to stimula te the capacity of companies to adopt new technologies. For this purpose, the IRC will use existing tools developed by the network ranging from the "BBS" to "Automatic Matching Tool" and to the "Internal Management Tool". It will also rely on its specific services such as technology transfer events, company missions, technology marketing and technology watch. Finally the IRC will use newly developed services such as innovation stimulation workshops, technology rating and SME clustering at the transnational level."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Scientific Network Surfactants and Dispersed Systems in Theory and Practise' (SURUZ).

assistant: **Concept**

Improvement of quality of life, protection of environment and economical use of energy and raw materials are requirements of our times. Miniaturization, which is one of the answer to these needs, means moving from macro- to micro- and nano-dimensions and to finely dispersed systems. The aim of this proposal is to network high quality scientific centres in Poland, which are involved in research on surfactant and dispersed systems. The activities of the network will concentrate on the basic research as well as on development of new compounds and technologies, which will find practical application. The organization of the network will facilitate exchange of the personnel, information and dissemination of scientific results. It will contribute to optimisation of use of research infrastructure available to the members of the network. The exchange of PhD students and young scientists will be especially encouraged to enable to learn techniques, which are not available in their home institutions. Organization of the network will prevent fragmentation, overlap of the research topics and favour cooperation. One of the aims of the network is coordination of action taken to participate in the 6th FP. The network will be subdivided into several thematic groups. The representatives of the groups will meet every year to exchange the results and informs other members of the network about the progress. Every two years the large conference 'SURUZ' will be organized with participation of invited speakers from scientific institution in EU. '