RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Unravelling Glycochemistry with Ion Mobility Spectrometry and Gas-Phase Spectroscopy' (GlycoSpec) under Horizon 2020.

assistant: **Objectives**

Oligosaccharides or glycans are essential in nature and central participants in virtually every biological process. The extensive structural diversity enables glycans to encode rich information in biological functions; however, it also creates major challenges in almost all aspects of the glycosciences. The synthetic formation of glycosidic bonds during glycan assembly for example, is mechanistically still not fully understood. This is largely a result of highly-reactive, but short-lived oxocarbenium ion intermediates, which are difficult to study using established techniques. However, the structure of these intermediates dictates the stereochemistry of the resulting glycosidic bond, the control of which is absolutely crucial for a successful synthesis. An equally important aspect is the sequencing of glycans, which is generally complicated by the frequent occurrence of isomers. This is further complicated by poorly understood rearrangement reactions during mass spectrometric analysis, which often lead to erroneous structural assignments. Here as well, cationic intermediates are the key species that determine the outcome of the rearrangement.The aim of GlycoSpec is to unravel fundamental aspects of oligosaccharide reaction and fragmentation mechanisms by probing cationic glycan intermediates. To do so, a unique combination of instrument and method development (ion mobility-mass spectrometry and cold-ion spectroscopy), chemical synthesis and theory will be used. The gain in mechanistic understanding will provide the basis to tailor building blocks and reaction conditions and is expected to lead to a major advancement in glycosynthesis. The mechanistic understanding of fragmentation reactions will furthermore lead to general rules for the prediction of tandem mass spectra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Samarium Diiodide Catalysis for Novel Bioiosteres' (Sam-4-Bio).

assistant: **Innovation**

The concept of bioisosteric replacement of arene pharmacophores in drug candidates has garnered increasing attention as a powerful tool to circumvent the production of toxic metabolites through detrimental metabolic modifications of the arene backbone. Replacement of the arene core in drug candidates with rigid, C(sp3)-rich bioisosteric scaffold improves their metabolic stability, potency, lipophilicity, and solubility. Crucially, cage-like structures with defined exit vectors renders them bioisosteres with superior ability to dock in the chiral binding pocket of the target receptor. Therefore, the demand for C(sp3)-rich bioisosteric replacements is skyrocketing and recent endeavors have provided a variety of decorated saturated systems mimicking substituted arenes. While initial studies were mostly directed towards bioisosteres of mono- and para-substituted arenes, recent efforts have focussed more on bioisosteres for ortho- and meta-substituted aromatic rings. Despite the significant development of synthetic strategies for preparing already proven bioisosteres, the lack of synthetic methods to access many unexplored analogues, such as bicyclo[2.2.1]heptanes (BCHeps), renders their potential undetermined to date. Consequently, developing general, catalytic, sustainable methods for rapidly accessing 1,2-BCHeps is an urgent necessity. Recent breakthroughs from the Procter group have set a new benchmark by applying radical relay catalysis using SmI2 for accessing bioisosteric scaffolds. Sam-4-Bio will integrate this novel concept with the group’s recent finding of enhancing catalytic efficiency of SmI2 by photoactivation, to develop a catalytic platform for accessing unexplored bioisosteres of ortho-arenes like 1,2-BCHeps. Challenging insertion of alkene into the bridgehe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Generation of prototissues from functional and chemoselective protocells' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Protocells are micro-compartments able to perform or mimic primitive biological functions of real cells. Because of this, they are proposed as stepping-stones towards the understanding of the origin of life on Earth. These “smart” microcapsules find potential applications in a variety of fields including medicine, pharmacology, energy conversion, and bioengineering. Progress in these fields will be considerably enhanced by gaining control over communication between protocells, as well as engineering collective functions of protocells.An important step towards the achievement of these goals can be made by employing bioorthogonal reactions. Bioorthogonal chemistry is a subclass of click chemistry that includes chemical reactions designed to occur in very complex media like the cell's cytosol. Bioorthogonal reactions are based on exogenous and atoxic reagents that react together quickly, chemoselectively and in quantitative yields. The introduction of bioorthogonal functionalities onto a protocell surface will open new possibilities in protocell engineering. In particular, the creation of bioorthogonally reactive protocells will represent the first step towards the creation of an unprecedented method for artificially controlling protocell communication and the assembly of prototissues with very high spatial and temporal control. The previous expertise of the applicant in the field of bioorthogonal chemistry and chemistry at the interface of materials will be applied to the multidisciplinary and emerging field of protocells in which the hosting group of Professor Stephen Mann FRS at the University of Bristol has been pioneering over the last few years. The key outcome of the combined research efforts of the applicant and the Mann group will lead to the synthesis of bioortho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Research and development of the European Transport Network Model – Transtools Version 3' to be submitted under Seventh Framework.

assistant: **Abstract**

The objective of the project is to upgrade and further develop the current TRANSTOOLS model, here referred to as TT2, to a new and improved European transport demand and network model (TT3).The project will improve the methodological basis of TRANSTOOLS, improve and validate its data foundation, deal with known deficiencies of the existing model, make the software faster and more efficient, and focus on the user needs, model documentation and model validation.The model will be updated to the 2010 base year based upon ETISplus data. The level of detail with regard to the rail, maritime and air transport modules will be increased. The aim here is to better analyse issues of cost, capacity and externalities of transport. The impact assessment model will be improved.Cross cutting activities will focus on methodological improvements of the model, updating and validating the data, re-estimating and re-calibrating the model, and performing an overall validation of the entire framework. Special focus will be on making the model more efficient with regard to calculation time, yet without compromising on the scientific validity with regard to causal relationships and described transport behaviour.The TT3 will deliver a validated, well documented and user friendly model that will provide policy makers with a tool for assessing and developing better transport policies. TT3 will continue the tool-box approach from prior versions of the model, which ensures that it can address the needs of many different types of user, for example analyses of EU-wise transport policies, analyses of TEN-projects and links to interregional and national project appraisals. The final model of TT3 will be IPR free and more open than the present model.The consortium ensures links back to TT1, TT2, a number
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Active Galactic Nuclei as probes of galaxy evolution' (AGNPROBES), addressing dissemination and exploitation.

assistant: **Impact**

An important question facing modern astrophysics concerns the formation and evolution of galaxies. Supermassive black holes reside at the centers of galaxies and are intimately linked to how galaxies form and evolve. Massive galaxies form by merging of smaller gas-rich galaxies, and the central supermassive black hole grows by accretion of gas and dust, material that also feeds a nuclear starburst. With sufficient fuel the black hole grows rapidly until it reaches an accretion luminosity powerful enough to expel gas and dust from the nuclear regions. Both the black hole and the galaxy bulge end up being starved of building material by the very same feedback process. Thus black holes and bulges evolve to similar mass ratios. As end products of galaxy evolution local massive galaxies show exactly this behaviour, known as the M-sigma relation; The mass of the black hole correlates with the velocity dispersion of stars in the bulge (the bulge potential). The origin of the black hole-bulge connection is still largely unknown and the physical details of the black hole feedback process is not known at all, it is included in models merely as a separate recipe. Models are in dire need of observational input. If models are correct, we expect to see some galaxies, perhaps at larger look-back times, that do not have a black hole-bulge mass ratio corresponding to that of local galaxies. This proposal will use galaxies with actively accreting supermassive black holes (AGN) to address the need for observational data at larger look-back times. AGN are not only the best probes for investigating the black hole-bulge connection in the more distant Universe, but also the only ones, because it is via black hole activity in AGN that we can estimate black hole masses. Central to the project i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enable eVeryone's Engagemet in the eneRgY transitiON' (Every1).

assistant: **Concept**

The Every1 consortium brings together leading experts in energy and education, and experts in ecosystems combined with social sciences to deliver an impactful concept that includes all elements needed to enable an effective participation of all European stakeholders in the digital energy market. Every1 starts from a deep data-informed understanding of stakeholders and ecosystems (citizen, cities, energy communities, companies, regulators, and distribution grid operators) to map who they are, what they know, how they use information and where they look for it.Similarly are existing and emerging solutions (products and services) assessed and validated, and use cases will serve to understand what stakeholders need to know in order to take up a role that matches their potential. This gap is used to develop learning pathways that lead to the identification of the needed capacity building material.Parallel, Every1 works on making a market by exchanging best practices with policy makers and energy regulators, enabling discussions on barriers, and developing joint communication material for their peers.A strong outreach campaign is launched which focusses on the local level with impactful social media campaigns, material in various languages and spread through the media the local stakeholders use. The operation of the ecosystems is based on the proven EXPLORE SHAPE UNITE approach and includes guided one-on-one support, joint activities, webinars, matchmaking, and more. Future ecosystems are actively engaged and trained, while cooperation with diverse activities and networks will lead to a wider uptake of the capacity building material.


**Keywords:** Energy transition, engagement, capacity building, awareness creation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'House Architecture and Heritage in modern Crete', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Cretan minor built heritage dating back to the Venetian and Ottoman periods has until now received scarce attention by scholars and local authorities. The two-year HArchitHeC project (House Architecture and Heritage in modern Crete) wants to focuses on rural and urban houses of Crete in order to reach three main goals: to perceive the built environment in its materiality and its historical evolution; to study how the evolution and interaction of Venetian and Ottoman cultural models built up a hybrid architecture in a colonial dimension; and to identify possible strategies for heritage protection by bringing research to the public realm. To do so, an interdisciplinary innovative approach will be used: a historical study of written sources and an architectural comparative study, by means of an inventory and a comparative study of Venetian and Turkish house prototypes. Such a pilot project aspires to a wider comparative study between Crete and the nearby regions, starting with other Mediterranean islands (Rhodes and Cyprus at first).HArchitHeC represents the first occasion to put into effect a mutual commitment between the two institutions that is the IMS (Greece) as the Host and Aix-Marseille University (France) as the Partner. They will provide an ideal human and scientific environment for the fellow, supporting her research and career development. The fellow’s previous achievements in terms of fieldwork and research, as well as her knowledge of Cretan territory and academic staff will allow her increasing methodologies and results. She will reinforce her competences and acquire new skills: her ultimate goal is to be fully integrated in the fields of cultural history and architectural heritage, acting on European society and science. HArchitHeC shows its relevance to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'STRUCTURAL ANALYSIS of HOUSEHOLD SAVINGS AND WEALTH POSITIONS OVER THE LIFE CYCLE' (1994-1998).

assistant: **Concept**

The overall objective of the research in the network is to improve our postdoctoral researchers joining the participating teams. The teams in the understanding of financial decision making by individuals and households, in particular with respect to savings, investment (portfolio choice), and network ail have ample experience in the area and provide adequate research facilities. This provides an ideal environmnent for training of young the provision for old age. The objective is motivated by the greying of researchers. Furthermore, we plan frequent workshops involving all teams, the population of the EU and the ensuing concern for the income position of the future generations of the elderly, and by the goals of the financial so the postdocs will have frequent exposure to the research of other sector (including banks and pension funds) to provide financial services teams in the network. to households that are adequate in view of the way in which these households view their future and make their decisions.  On the basis of micro-datasets from different countries both fundamental and applied research into household and individual financial decision making will be undertaken. Partly researchers will use datasets from their own country in a cross-country comparison framework, partly the same (very extensive) data set will be used by different teams. Furthermore, laboratory experiments will be part of the project and economists, econometricians, and psychologists will collaborate. The fundamental research topics studied include the precautionary, bequest and other motives for saving, experimental work on time preference, risk aversion, and decision making about savings. The applied work will include the relation between private savings and pension provisions; portfolio choice
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Biological detection with functionalized Magnetic Sensor' in the context of a Horizon 2020 call.

assistant: **Objectives**

The key goals of the BIDMAG project are: a) the training of a talented experienced researcher, Dr Lopes, in the fast growing field of science, technology and industrial applications of magnetic biosensors, where the host has a critical knowledge and expertise; and, b) design, development and optimisation of cost-efficient smart hybrid surfaces onto magnetic substrates, able to present magnetic response for detecting bacteria. The interdisciplinary training program includes magnetic materials surface modification, fabrication,  modelling, characterisation of Magnetoelastic Resonators (MER), surface biofunctionalisation and detection of the biological parameters, which will enhance and broaden her expertise and increase her exposure to both academic and industrial collaborations. She is a talented researcher who has gained much expertise in interdisciplinary area of electroactive polymer composites during her postgraduate career. This background is invaluable for applying in preparation and characterisation techniques of smart materials. To further her career in magnetic biosensors Dr Lopes needs to gain expertise in functional materials and magnetic characterisation, fields in which BCMaterials has a world-recognised expertise. Additionally, through secondments at academic and industrial co-hosts, at ACREO and VAC, respectively, she will gain additional training in: industrial production of MER and Optimization of compact and commercial MER interrogation systems.The impact of the project will be multidisciplinary, since it has applications ranging from environmental monitorization and food quality control to fast medical diagnostics. Besides, to further boost her career, Dr Lopes needs to increase her supervision and teaching experience, gain project and intellectual pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Systems Chemistry from Bottom Up: Switching, Gating and Oscillations in Non Enzymatic Peptide Networks', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The study of synthetic molecular networks is of fundamental importance for understanding the organizational principles of biological systems and may well be the key to unraveling the origins of life. In addition, such systems may be useful for parallel synthesis of molecules, implementation of catalysis via multi-step pathways, and as media for various applications in nano-medicine and nano-electronics. We have been involved recently in developing peptide-based replicating networks and revealed their dynamic characteristics. We argue here that the structural information embedded in the polypeptide chains is sufficiently rich to allow the construction of peptide 'Systems Chemistry', namely, to facilitate the use of replicating networks as cell-mimetics, featuring complex dynamic behavior. To bring this novel idea to reality, we plan to take a unique holistic approach by studying such networks both experimentally and via simulations, for elucidating basic-principles and towards applications in adjacent fields, such as molecular electronics. Towards realizing these aims, we will study three separate but inter-related objectives: (i) design and characterization of networks that react and rewire in response to external triggers, such as light, (ii) design of networks that operate via new dynamic rules of product formation that lead to oscillations, and (iii) exploitation of the molecular information gathered from the networks as means to control switching and gating in molecular electronic devices. We believe that achieving the project's objectives will be highly significant for the development of the arising field of Systems Chemistry, and in addition will provide valuable tools for studying related scientific fields, such as systems biology and molecular electronics.