RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Graphene Layers: Production, Characterization and Integration' under Seventh Framework.

assistant: **Concept**

GLADIATOR (Graphene Layers: Production, Characterization and Integration) will enable the scalable production of cheaper, higher quality and larger area graphene sheets. The project will achieve this by optimizing the performance of CVD graphene (using doping), by increasing the throughput and size of CVD batch reactors, and by improving the process by which graphene is transferred for the CVD catalysts to the application substrate. GLADIATOR directly targets the gobal market for transparent electrodes (estimated to be worth over 11,000 million USD in 2016) and will demonstrate that the performance and price of indium tin oxide can be matched by graphene (transparency > 90%, sheet resistance < 10 Ohm/sq, cost < 30 Eur/ square meter). The new production technologies will be demonstrated by making ultraviolet organic photodiodes (possible application as fire sensors) and large area flexible OLEDs.CVD graphene production will be optimized using new diagnostic and process control instrumentation based on Raman spectroscopy and spectrometric ellipsometry; the quality of graphene layers post-transfer will be assured using new non-contact in-line eddy current measurements and THz imaging. CVD production costs per unit area will be reduced not only by the process parameter optimization, but also by developing methods to re-use the catalysts and by increasing the size of the reactor chamber. The process safety will be addressed, too.A critical issue for graphene, especially as a transparent electrode, is how to achieve homogenous large area coverage. GLADIATOR will extend the size of graphene layers beyond that of the CVD tools by implementing a novel patchwork process using a transfer process with high yields and negligible impact upon the properties of the graphene. Transfer p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Bio-inspired AntiMicrobial Bone BIoceramics: Deciphering contact-based  biocidal mechanisms' (BAMBBI) targeting Horizon Europe.

assistant: **Abstract**

Bacterial bone infections are one of the great challenges of orthopaedic and maxillofacial surgery, aggravated by antibiotic resistance, a serious health threat responsible for 700,000 deaths per year. The recent discovery of the bactericidal properties of some naturally occurring surface topographies has opened a new avenue of research. However, there is incomplete knowledge of the mechanisms of action and too many unanswered questions to translate these advances into clinical use. BAMBBI aims to tackle this challenge by developing synthetic bone grafts featuring contact-based antimicrobial properties, adding antimicrobial activity to their capacity to support bone regeneration. Using a novel bottom-up approach inspired in biomineralization routes, I intend to engineer the surface of calcium phosphates with an unprecedented and fine control of nanotopography by harnessing the power of ions and organic molecules (e.g. amino acids, calcium chelators and surfactants) to drive crystal nucleation and growth. Moreover, we will further enhance the antimicrobial effect by exploiting the synergy with chemical moieties to modulate bacterial affinity for the surface and/or confer additional antimicrobial properties by immobilisation of antimicrobial peptides. This will provide us with a platform to study the contact-based bactericidal mechanisms in depth and unravel the role of nanotopography and surface chemistry and their interplay with the intrinsic properties of bacteria. Only considering all these parameters will it be possible to unveil the causes of the substantial differences in bactericidal efficacy of a given substrate for different bacteria and design more efficient antibacterial surfaces. In addition to being a major breakthrough in the field of bone regeneration, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'EATRIS-CONNECT' under Horizon Europe.

assistant: **Concept**

Since the establishment of EATRIS as an ERIC in 2014, the infrastructure has developed a growing portfolio of services and collaborative projects serving several user groups including industry (large pharma and SME), academia, research funders and patients. EATRIS has progressed from proposing a strong proof of concept service portfolio, to building and delivering innovative tools for translational research and is now advancing its strategy to further exploit these tools for the extended research and innovation community.EATRIS-CONNECT will accelerate this strategy by focusing specifically on advancing the digital readiness of EATRIS to support biomedical challenges in Europe and provide translational solutions for the benefit of personalised medicine. Through curated access to novel digital tools and services, as well as node strengthening, EATRIS-CONNECT will equip EATRIS across the entire distributed research infrastructure to address bottlenecks and challenges for the application of digital solutions in the context of use. Moreover, the project will ensure this digital transformation is environmentally sound by improving energy, resource, and material efficiency, supporting the environmental goals of the European Green Deal. The project will promote the cross-border alignment in the adoption and application of digital tools and help consolidate the European RI landscape by fostering interdisciplinary collaborations between cross-sector RI and exploring how RI can together unlock innovation in the digital domain. EATRIS-CONNECT will provide the pathway for the evolution of EATRIS. All 14 national EATRIS nodes form the central pillar of EATRIS-CONNECT, facilitating the alignment of strategic national priorities across the infrastructure and empowering EATRIS widening
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ReAlising DynamIc vAlue chaiNs for underuTilised crops' (RADIANT).

assistant: **Innovation**

RADIANT implements a suite of strategic and fully inclusive multi-actor engagement methods to co-develop solutions and tools to ensure that agrobiodiversity in the form of underutilised crops (UCs) is realised via Dynamic Value Chains (DVCs).  RADIANT characterises DVCs as ’a system-state where open information sharing among all value-chain actors allows resilient adaptation to disruptions and sustainable economic development’. RADIANT adopts a ‘Theory of Change’ approach, where desired system-level states, such as crop diversification, environmental and agrobiodiversity preservation, and fair economic development are monitored and mapped to identify and implement the necessary transformation avenues. RADIANT’s 28 multi-actor consortium is composed of highly skilled value chain actors, researchers, and end-users. The scientific excellence of the work plan will release the value of UCs and enable a transformation towards sustainable DVCs that foster agrobiodiversity in educational, financial, technological settings and effectively provisions UCs to farmers’ fields and consumers’ tables. This will be achieved via eight complementary work packages to: identify, collect, and multiply the genetic resources of core UCs for breeding and farming; widen UC recognition by capturing their ecosystem services; enhance their processing by co-creating novel food and non-food products; invite stakeholders and aspiring participatory farmers into a capacity-building, mentoring-network to trial, test, and embed UCs in sustainable DVCs; co-creating Apps and ‘UC-Transition Diaries’ to record their transformation; and engage stakeholders to co-design policy instruments, and deliver a decision support tool to create sustainable avenues for DVCs. In sum, the RADIANT approach will empower value
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SWIFT Component development by concurrent life cycle phases' in the context of a Fifth Framework call.

assistant: **Objectives**

The project will develop and apply an innovative paradigm for the life cycle of quick software components production. This paradigm is based on the parallel concurrent execution of the main phases of the software life cycle: Coding, Testing, and Documentation plus training. There are not so many precedents of such life cycle implementation that have been successful in Europe. Most of them are academic research; in fact we do not know any adoption case in the European industry. Our improvement action includes a new organisational framework for software development based upon:- specialised teams with shared responsibility,- the formal description of the new life-cycle, its phases, milestones and work products,- the development of a detailed rules for the work of each team on each phase.The new model will be tested and evaluated through its application over a Baseline project, consisting in the development of an innovative graphical user interface module over Internet for our original SCADA, control system and data acquisition software ICEBERG.Objectives:The final target of the proposed action is to acquire for our company a new advanced process for the quick development of software components, which can provide a high productivity with high level of quality. Specific objectives are:- Time-to-market reduction of a product.- Component reusability by means of a double domain and application engineering.- Incremental tests of components all along their development.- Control and assurance of the Product Quality.The project will bring experimental evidence, validation and viability of the advantages of the new life cycle paradigm, and can be useful to help the decision of its adoption in our company and others. Those technical objectives are related to the primary business obje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Game-changing Precision Medicine for Curing All Myeloproliferative Neoplasms'.

assistant: **Concept**

Despite decades of research, developing ways to overcome drug resistance in cancer is the most challenging bottleneck for curative therapies. This is because, in some forms of cancer, the cancer stem cells from which the diseases arise are constantly evolving, particularly under the selective pressures of drug therapies, in order to survive. The events leading to drug resistance can occur within one or more individual cancer stem cell(s) – and the features of each of these cells need to be studied in detail in order to develop drugs or drug combinations that can eradicate all of them. The BCR-ABL+ and BCR-ABL- myeloproliferative neoplasms (MPN) are a group of proliferative blood diseases that can be considered both exemplars of precision medicine and of the drug resistance bottleneck. While significant advances in the management of MPN have been made using life-long and expensive tyrosine kinase inhibitors (TKI), patients are rarely cured of their disease. This is because TKI fail to eradicate the leukaemia stem cells (LSC) from which MPN arise and which persist in patients on treatment, often leading to pervasive drug resistance, loss of response to therapy and progression to fatal forms of acute leukaemia. My goal is to change the way we study the LSC that persist in MPN patients as a means of delivering more effective precision medicine in MPN that is a “game-changer” leading to therapy-free remission (TFR) and cure. Here, I will apply an innovative strategy, ChAMPioN, to study the response of the MPN LSC to TKI in innovative pre-clinical laboratory models and directly in patients with MPN - up to the resolution of individual LSC. This work will reveal, for the first time, the molecular and clonal evolution of LSC during TKI therapies, thus enabling the development o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tenancy Law and Housing Policy in Multi-level Europe', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Private tenancy law is existentially affecting the daily lives of European citizens, as about one third of them depend on rental housing. That notwithstanding, it constitutes a nearly blank space in comparative and European law. This is due to its national character, its political nature and its embeddedness in widely diverging national housing policies, which ultimately reflect different welfare state models.At the same time, however, different parts of EU law and policy do affect tenancy law significantly, albeit indirectly. Thus, EU social policy against poverty and social exclusion extends to selected issues of housing policy. EU non-discrimination rules extend to the provision of housing, and several consumer law directives apply to tenancy contracts, too. Moreover, if the Common Frame of Reference were one day to develop into an optional instrument, tenancy law issues now regulated by national general contract law might be covered as well - though without any legislator having co-ordinated the ensuing juxtaposition of European contract law and national tenancy regulation.Against this background, this project sets out to provide the first large-scale comparative and European law survey of tenancy law. In a first step, it analyses national tenancy laws and their embeddedness in, and effects on, national housing policies and markets. In a second step, the effect of EU legislation on national housing policy in general and national tenancy law in particular will be analysed in a comparative perspective. In a third step, a proposal for a better co-ordinating role of the EU in tenancy law and housing policy, in particular through an OMC process developing common principles of good “tenancy regulation”, will be designed.This research matches well several priorities of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Providing a Digital and Modular Ecosystem for Personalized Capabilities Development to Enhance Labour Market Participation and Employment Transition' (DIAMOND).

assistant: **Concept**

The main goal of DIAMOND is to guide individuals from vulnerable socio-economic backgrounds on their pathway to employment, by tailoring learning programmes to individual needs, and bolstering employability. This is achieved by developing two unique solutions: 1) the Employability Growth Index (EGROW Index) - a comprehensive taxonomy of individuals employability growth, including their empowerment and transformative (digital & green) capabilities (objective 1). The EGROW Index will act as a measurement tool for classification and segmentation of user groups regarding the content and format of learning programmes. 2) the Modular and Versatile Platform for Engagement and Employability (MOVE) – a digital platform for lifelong learning with person-centered micro-credentials and learning formats (objective 2). On MOVE individuals can grow their employability based on EGROW and skill forecasts by participating in concise skill programmes recommended by an AI-supported system. To benchmark the impact breadth of the EGROW Index and MOVE, econometric cost-benefit analyses and a stochastic life-cycle model are applied (objective 3). The objectives are enabled by a vibrant research and innovation environment – the Grassroot Living Lab. State-of the art social innovation experiments, iterative research and stakeholder integrated co-creation will validate the DIAMOND solutions. DIAMOND targets directly the main impact goals associated with the call. The EGROW Index will help individuals to assess their employability growth and to empower them to self-manage their skill development on MOVE. The increased engagement due to tailored learning programmes will facilitate an increased labour market participation. The economic analyses and model provide an improved understanding of macro-ec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Studies of transcription-coupled modifications of chromatin' under Sixth Framework.

assistant: **Concept**

The aim of current research project is to characterise the changes of the chromatin structure necessary for efficient elongation of transcription by RNA polymerase II, and also reveal the key interactions between chromatin modifications and transcriptional elongation. Analysis of chromatin structure, in the context of transcriptional activity of the gene, will be carried out in the budding yeast (Saccaromyces cerevisiae) model system. Also the mechanisms leading to removal of nucleosomes from actively trans cribed genes will be studied.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Targeting cardiac fibrosis with next generation RNA therapeutics' (FIBREX).

assistant: **Innovation**

The aim of FIBREX is developing a novel, highly innovative and close to clinical readiness noncoding RNA (ncRNA)-based antisense oligonucleotide therapeutic for the treatment of heart failure (HF) derived from cardiac fibrosis. HF is the most common cause of morbidity and mortality with pressing social and economic burden. HF remains a deadly disease with no curative treatment, underlining the need for innovative therapeutic strategies. The revolutionary technology we are proposing acts by reversing cardiac fibrosis, the main driver of HF development and progression. The excess fibrotic tissue leads to continous stiffening and impairment of the heart muscle. In our prior work, ncRNA Meg3 was identified as the most promising target, expressed mainly by cardiac fibroblasts and by consistent transcriptional dysregulation in HF models. The critical role for Meg3 in cardiac fibrogenesis was validated both in vitro and in vivo and a lead compound targeting Meg3 showed promising efficacy in relevant models, human tissues and excellent exploratory safety data. We propose a development project for an antiMEG3 inhibitor to reach close to clinical readiness, by completing non-clinical pharmacodynamic and safety studies.This work will be carried out by an experienced team headed by Prof. Thum, with a track record of discovering and licensing various ncRNA inhibitors programs, and creating a clinical stage spin-off company Cardior, reaching phase 2 development and Series B funding. We are confident that our technology with the requested support will be further advanced into an innovative novel drug candidate and, driven by the substantial value increase, the project will be transitioned into a spin-off drug development or a licensing-deal with the industry. The development of the un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Choreographies of vulnerability :towards a new public ethics of care' (ChoreoCare).

assistant: **Concept**

The project assumes the “vulnerability paradigm” as a theoretical framework that enables an innovative understanding of collective social, political, health-related, and economic phenomena, including the protests against structural racism that have been organized inside and outside the United States after George Floyd’s death on May 25th. ChoreoCare aims to shape a new ethical approach by framing an argument in favour of it situated in political theory. The argument is that, if a collectivity recognizes vulnerability as a condition that all individuals embody, although each one in a different way and with different resources, it will also promote practices of care as a necessarily shared task.  I have coined the notion of “choreographies of care”, which identifies the public and concerted mode of acting together performed by subjects who recognize their own and the others’ social embeddedness, embodied vulnerabilities, and mutual dependencies. ChoreoCare adds to feminist theorists who have remarked the importance of how a bodily political performance is narrated and acted out in public discourse, insisting on the urgency of counter-narratives. It takes into consideration the aesthetics of different collective efforts in the name of care. I have selected several scenes in which vulnerability is exhibited and, I claim, a collective demand for care is in place. I will compare and connect the political discourse related to feminist collective actions, ranging from the feminist strikes organized in Argentina and Mexico in March 2020 with the aim to protest violence against women, to the “Wall of Moms”, a public demonstration that took place in Portland, Oregon in July 2020 in support of the Black Lives Matter protests. We can find examples of this kind of collective performa