RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Role of the protein kinase Mastl in Cell Division and Cancer' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The cell division cycle is an essential step in living organisms. Different studies have led to a model where cell cycle kinases act as major engines to promote cell cycle progression throughout the different phases of the cell cycle. In addition to Cyclin- dependent kinases (Cdks), Polo-like and Aurora kinases, other kinases have recently emerged as important regulators of cell cycle progression. Among them, a new kinase known as Mastl in mammals, and Greatwall in Xenopus and Drosophila, has been shown to be important for mitosis. The decision to enter mitosis and the maintenance of the mitotic state depends on phosphorylations by Cyclin B/Cdk1 complexes, which can be counteracted by the phosphatase PP2A. Recent studies have pointed to Mastl/Greatwall as a critical regulator of PP2A in this context.The aim of this project is to characterize the function of Mastl in the cell cycle in mammalian cells, and to evaluate its potential as target for cancer therapy. Three complementary lines of investigation will be used to address this issue:1. Analysis of Mastl function in vivo in a Mastl knock-out mouse, and in different cellular systems derived from that model, such as embryonic fibroblasts and induced pluripotent stem cells (iPSs).2. Identification of Mastl interactors and substrates through the combination of chemical genetics and proteomic methods.3. Validation of Mastl as a target for antitumoral therapy by inhibition of Mastl, alone or in combination with other therapies, in human tumor cell lines and in cancer mouse models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Intelligent data-driven pipeline for the manufacturing of certified metal parts through Direct Energy Deposition processes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The industrialisation of Additive Manufacturing (AM) requires a holistic data management and integrated automation. INTEGRADDE aims to develop an end-to-end Digital Manufacturing solution, enabling a cybersecured bidirectional dataflow for a seamless integration across the entire AM chain. The goal is to develop a new manufacturing methodology capable of ensuring the manufacturability, reliability and quality of a target metal component from initial product design via Direct Energy Deposition (DED) technologies, implementing a zero-defect manufacturing approach ensuring robustness, stability and repeatibility of the process. To achieve this aim, INTEGRADDE addresses following key innovations:-  Development of an intelligent data-driven AM pipeline. - Combination of automatic topology optimisation algorithms for design, multi-scale process modelling, automated hardware-independent process planning, online control and distributed NDT for the manufacturing of certified metal parts.- A self-adaptive control is adopted focused on the implementation of non-propagation of defects strategy. Moreover, Data Analytics will provide a continuous refinement by acquiring process knowledge to assist in the manufacturing of new metal components, improving right-first-time production by adopting a mass customization approach- Cybersecurity ensures data integrity along the AM workflow, providing a novel manufacturing methodology for the certification of metal AM parts.INTEGRADDE implements a twofold deployment approach for the pilot lines: both in application-driven at five industrial end-users (steel, tooling, aeronautics, and construction) and open-pilot networks at RTOs already owning AM infrastructure (AIMEN, IREPA, CEA, WEST). This will allow a continuous validation and deployment of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Coinduction for Verification and Certification' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Software and hardware bugs cost hundreds of millions of euros every year to companies and administrations. Formal methods like verification provide automatic means of finding some of these bugs. Certification, using proof assistants like Coq or Isabelle/HOL, make it possible to guarantee the absence of bugs (up to a certain point).These two kinds of tools are crucial in order to design safer programs and machines. Unfortunately, state-of-the art tools are not yet satisfactory. Verification tools often face state-explosion problems and require more efficient algorithms; certification tools need more automation: they currently require too much time and expertise, even for basic tasks that could be handled easily through verification.In recent work with Bonchi, we have shown that an extremely simple idea from concurrency theory could give rise to algorithms that are often exponentially faster than the algorithms currently used in verification tools.My claim is that this idea could scale to richer models, revolutionising existing verification tools and providing algorithms for problems whose decidability is still open.Moreover, the expected simplicity of those algorithms will make it possible to implement them inside certification tools such as Coq, to provide powerful automation techniques based on verification techniques.  In the end, we will thus provide efficient and certified verification tools going beyond the state-of-the-art, but also the ability to use such tools inside the Coq proof assistant, to alleviate the cost of certification tasks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'An innovative Cylindrical Gas Electron Multiplier Inner Tracker for the BESIII Spectrometer' to be submitted under Horizon 2020.

assistant: **Abstract**

Inner Trackers (IT) are key detectors in Particle Physics experiments; excellent spatial resolution, radiation transparency and hardness, and operability under high occupancies are main requirements. While planar Gas Electron Multiplier (GEM) detectors are common in modern spectrometers, only one Cylindrical-GEMs (CGEM) detector has been produced up to now by the KLOE2 Collaboration and is being commissioned.We aim to design, build and commission by 2017 a CGEM detector candidate to be the new IT of the BESIII spectrometer, hosted on BEPC2 in IHEP, Beijing; BESIII data taking will last until at least 2020. The IT itself will represent an evolution w.r.t. the state of the art of GEM (and CGEM) detectors, since the use of new kind of supports for the GEM foils will reduce the total radiation length of the detector and improve its tracking performance; an innovative design of the CGEM anode will allow for smaller capacitance and hence for bigger signals.The relatively strong BESIII magnetic field requires a new analogue readout; full custom front-end electronics, including a dedicated ASIC, will be designed and produced for optimal data collection.Specific software will be developed to first simulate, and then reconstruct the CGEM hits to detect reaction products.Proper benchmark channels will be identified and investigated to maximise the outcome of the project.An existing cloud infrastructure hosting a virtualised grid Tier-2 will be further expanded, providing an advanced environment optimised for scientific computing, suitable to investigate specific tools beyond commercial standards as well.The project could significantly enhance the already established interaction between the participating EU and Chinese Institutions in BESIII, strengthening in particular those techn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'NorrDigi revolutionary Energy Saver'.

assistant: **Concept**

Norrhydro Oy is a Finnish hydraulic cylinder manufacturer. Since 2007, Norrhydro has developed a technology, NorrDigiTM, that has the ability to regenerate, store and share energy by the functions on mobile equipment, such as excavators, the largest market for cylinders. The economic effect of NorrDigiTM is very significant. It requires less space, is cost neutral and has proven 45-60% fuel efficiency improvement and 5-12% productivity gains in side-by-side tests with a standard excavator. NorrDigiTM is a modular control system made of highly engineered hydraulic cylinders, control valves, sensors and electronics in an integrated control package and is patented in all major countries. The initial target market is crawler excavators and large material handling equipment. The current addressable market size is 4,0 billion euros yearly. The first goal is a 5,6% market share by 2025, which means total sales will grow from 19 to 260 million euros in that period. The next target is 15% market share by 2028, which coupled with growth in adjacent markets will amount to over 800 million in annual sales. The imminent market launch is based on finalizing the product designs, testing, production investments and increased marketing. The solution is scalable, and Norrhydro performs an internal investment and LEAN improvement program to meet the increased volume demands. The other main components are modular and come from suppliers who have ample capacity. The direct effect on employment goes from 126 people in 2017 to 700 people by 2025. The SMEI-funding will assist in speeding up the launch, reduce risks, and improve the economics and the environment due to the drastically reduced fuel consumption (emissions). The funds will help securing additional financing which is planned as an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Post-genomic analysis of microbial virulence' (1998-2002).

assistant: **Innovation**

The Marie Curie Training Site is a consortium of young, dynamic researchers housed in the Department of Biology and Biochemistry at the University of Bath. The University was last ranked 7th in England for research quality and the Department has achieved top grades for both teaching and research. There are 60 graduate students in the Department. The Training Site uses state of the art techniques and approaches to understand the wider biological implications of microbial virulence. The focus is on interdisciplinary research and interactions with other research groups. This is emphasized by the wide-ranging interests of the single department. Training will be offered in a range of techniques appropriate to the needs of the applicant. These include X-ray crystallography , 600MHz NMR, high throughput capillary DNA sequencing, confocal microscopy, bioinformatics on a dedicated molecular biology computing facility, transmission and scanning electron microscopy and atomic force microscopy. The program is designed for students to discover post-genomic analysis in a cradle-to-grave approach, from isolation of the genes involved to detailed studies of their structure-function and behavior in natural populations. The breadth of microbiology available in the Department of Biology and Biochemistry at Bath makes us a world leader in the analysis of virulence factors.The particular expertise is ina) the molecular basis of pathogenesis and symbiosis in microbe-insect and microbe-nematode interactions,b) structure-function relationships of microbial effectors, and c) in epidemiology and theory of drug resistance and evolution and modeling. The applicants should be experienced doctoral students who will probably come to the University of Bath just before their final year of study at the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'G-Quadruplex-associated proteins (QAPs) and their role in transcriptional regulation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In the human genome, many G-rich sequences have the potential to form 4-stranded non-canonical secondary structures known as G-quadruplexes (G4s). G4 structures have been visualized in nuclei by immunofluorescence and mapped genome-wide to regulatory chromatin regions linked to elevated transcription using G4 chromatin immunoprecipitation and high-throughput sequencing (G4 ChIP-seq). G4s are implicated in gene regulation, DNA replication and genome instability, yet little is known about their protein interaction partners or role in regulating genome activity. We therefore propose to develop G4 Rapid Immunoprecipitation Mass Spectrometry of Endogenous Proteins (G4 RIME) methodologies to elucidate the G4 interactome within a native chromatin context. ChIP-seq of protein candidates coupled with G4 ChIP-seq will verify binding at endogenous G4 structures. Using established biophysical and biochemical techniques, we will investigate binding modes, recruitment and effects on G4 dynamics. Consecutive chromatin immunoprecipitation steps using antibodies targeting characteristic chromatin marks as well as G4 ChIP-seq supported by bioinformatics analysis of genomic databases will identify proteins involved in transcriptional regulation. We will then test the consequence of stabilising G4s with small molecule ligands on the G4 interactome and how this is modulated during genomic stress. Cells genetically deficient in G4-interacting proteins will enable detailed exploration of G4 formation and transcriptional effects. This highly interdisciplinary project will provide a wide range of excellent training opportunities exploiting the Balasubramanian group’s unique position with laboratories at the Cancer Research UK Cambridge Institute (CRUK CI) and the Department of Chemistry. Overal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'FI-WARE: Future Internet Core Platform'.

assistant: **Objectives**

The goal of the FI-WARE project is to advance the global competitiveness of the EU economy by introducing an innovative infrastructure for cost-effective creation and delivery of services, providing high QoS and security guarantees. FI-WARE is designed to meet the demands of key market stakeholders across many different sectors, e.g., healthcare, telecommunications, and environmental services. FI-WARE unites major European industrial actors. The key deliverables of FI-WARE will be an open architecture and a reference implementation of a novel service infrastructure, building upon generic and reusable building blocks developed in earlier research projects. We will demonstrate how this infrastructure supports emerging Future Internet (FI) services in multiple Usage Areas, and will exhibit significant and quantifiable improvements in the productivity, reliability and cost of service development and delivery – building a true foundation for the Future Internet. From an architectural perspective, FI-WARE is based on the following main foundations:  Service Delivery Framework – the infrastructure to create, publish, manage and consume FI services across their life cycle, addressing all technical and business aspects.  Cloud Hosting – the fundamental layer which provides the computation, storage and network resources, upon which services are provisioned and managed.  Support Services – the facilities for effective accessing, processing, and analyzing massive streams of data, and semantically classifying them into valuable knowledge.  IoT Enablement – the bridge whereby FI services interface and leverage the ubiquity of heterogeneous, resource-constrained devices in the Internet of Things.  Interface to Networks – open interfaces to networks and devices, providing the conn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Women scientists in Gender-Specific Technological R&D - How do women scientists in technological R&D respond to the needs of women end-users?'.

assistant: **Innovation**

The project aims at clarifying the process of how women scientists engaged in technological R&D respond to the needs of women end-users. The study will display economic and socio-cultural factors that influence gender-specific end-user interaction with women researchers by comparing and analysing gender equality in R&D in the cases of two transition economies - Poland and China - and two technological applications - teleservices and agricultural implement. The Polish and Chinese societies are experiencing a rapid economic and technological transition. Demand for technology is diversifying and the structures of end-users in different technological fields are being re-shaped. In the process, women in China and Poland have become crucial user groups for technical applications both in the traditional agricultural sector and the rapidly growing telecom sector.This development requires more gender-specific R&D and the harnessing of social capital of women in R&D. An attractive environment for investors and strong scientific bases make both China and Poland significant actors in technological research. Women have equal opportunities for higher education in these countries and in Poland women are generally better educated than men. However, women are poorly represented in scientific research, particularly in the fields of engineering and natural sciences. Moreover, the male perspective is the norm in technological R&D and articulation of demand for new products is the prerogative of men. Gender equality may be on the political agenda but is hardly addressed in technological R&D.This study will clarify the opportunities for women scientists in technological R&D to interact with women end-users. Based on the results of the study, policy recommendations will be formulated for bett
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Time in Medieval Japan' (TIMEJ).

assistant: **Innovation**

The project explores time in medieval Japan, taking a new approach to historical articulations of the concept of time, based on the theory of symbolic forms. It will examine symbolic representations and social regulations of time in a civilisation that is often juxtaposed to contemporary, globalised modernity. We will investigate into medieval Japan as a dynamic and internally differentiated society, and not as a unified “traditional” culture dominated by a qualitative concept of time. We will focus on its plural ways of registering, measuring, articulating, and regulating time. The aim is to disclose the specific cultural practices operative in the respective ways of negotiating time, and to achieve a more comprehensive and detailed account of human strategies in dealing with this fundamental restriction of our existence. In a closely coordinated set of case studies, we examine representative spheres connected to various symbolic forms and socio-cultural agendas: the Zen monastery, the female court, and the market. An intersectional case study explores the symbolic mediations of the menstrual cycle, connecting these spheres and uniting aspects of the physical, ritual and symbolic regulation of human body time. Each case study explores the symbolic forms prevalent in the respective settings, and the aspects of time that are deemed relevant and selected for symbolic articulation. We will analyse temporal encoding, structure and application in the regulation of affairs, the competence to account and regulate these processes, and the influence on feelings of dismay in the face of the socio-cultural realities of time. Special attention is paid to the conflicts that arise when established regimes of temporal regulation and expression clash with each other and with individual