RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'VERA: Extracellular VEsicles, miRNAs and particulate Air pollution: developing a new tool to identify subjects with high exposure-associated cardiovascular risk' (VERA) under Horizon 2020.

assistant: **Objectives**

Air pollution exposure, in particular the particulate matter (PM) component, has been consistently linked to an increased risk of developing acute and chronic cardiovascular diseases (CVD). The SPHERE (""Susceptibility to Particle Health Effects, miRNAs and Exosomes"") project was granted by ERC-2011-StG 282413 and hosted by the “Università degli Studi”, Milan, Italy, to examine possible molecular mechanisms underlying the effects of PM exposure in relation to health outcomes. In this project, in particular, we investigated the role exerted by extracellular vesicles (EV) and their miRNA cargo in mediating the cardiovascular effects of PM exposure. EVs might be the ideal candidate to mediate the effects of PM, since they could be potentially produced by the respiratory system, reach the systemic circulation and lead to the development of cardiovascular effects. In the SPHERE study, we confirmed in a population of obese subjects that PM is able to stimulate EV release in plasma and we were able to identify a EV-specific miRNA signature, responsive to PM exposure. One of the most important gaps in our current knowledge regarding PM-related cardiovascular health effects is the identification of susceptible subjects. This identification would provide the groundwork for the development of prevention strategies and of targeted treatments. The Proof of Concept project VERA (Extracellular VEsicles, miRNAs and particulate Air pollution: developing a new tool to identify subjects with high exposure-associated cardiovascular risk) aims to confirm the commercial and technological feasibility of a tool for testing EV-specific miRNA expression, in order to identify subjects with an higher susceptibility to PM. We propose scientific activities which will validate the project SPHERE fin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Take-off and Landing on Runways Contaminated by Standing Water, Slush or Snow' (CONTAMRUNWAY).

assistant: **Concept**

The aim of the CONTAMRUNWAY study is to support the J.A.A. needs in reviewing the validity of the existing requirements for operation on runways contaminated by rain/snow/ice for small and commuter aircraft.Because of the width of the subject, this study is limited to the determination of the contaminated runway drag and the aquaplanning speed of wheels free to roll (no braking), i.e. :- identify the most important parameters acting in the drag.- assess difference with AMJ 25 x 1591 Supplementary Performance information for take-off from wet runways and for operation on runways contaminated by standing water, slush, loose snow, compactedsnow or ice". - establish elements to reformulate theoretical drag on contaminated runway and determine the aquaplaning speed of wheels free to roll, by tests conducted in water ponds. - give elements to relevant authorities in order to modify if necessary the current regulations.Links with other projects, tasks, areas, programmes, policy actions:Technical exchange will be made when appropriate with two ongoing projects : - CAA funded ESDU research, which is mainly a review of existing data. - Five year Winter Runway Friction Measurement Program conducted in North America by Transport CANADA, FAA, NASA, and National Research Council CANADA. This program concentrates on the deceleration performance (braking) and the contaminant is mainly snow.Case studies- Cranfield University, GB (to be confirmed) - Centre d'Essais en Vol Brétigny, FR"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'CLIMAte change citizens engagement toolbox for dealing with Societal resilience'.

assistant: **Objectives**

Climate change is one of the most critical issues to tackle today as it is foreseen to have detrimental social, environmental and economic impacts in the near future. The last climate change events, such as flooding in Germany and Belgium in both Continental and Atlantic regions, heat waves and lack of water in both Mediterranean and Boreal regions, show that the policymakers, experts and stakeholders' actions are not enough, and a 360º citizens engagement is urgently needed. Therefore, we need to learn from the good experience in citizens' engagement in climate change action and build up citizens` supporting infrastructure for climate adaptation measures to help the 150 European regions and local communities to resist. Climate assemblies and Living labs are considered as sustainable and reasonable tools to stimulate deliberative democracy in climate policymaking. The ambition of the current project is to support a transformation to climate resilience by offering an innovative problem-oriented climate adoption Toolbox, co-designed together with stakeholders by applying a values-based approach, design thinking methods and citizen science mechanisms. It is expected that the use of the Toolbox will anticipate possible tensions, points of controversy and dilemmas vis-a-vis the adaptation to resilience - therefore enabling empowerment and engagement strategies that produce a society ""resilient by design"". In addition, CLIMAS will include the empirical component for testing this Toolbox and formulating scientific-based guidelines for policymakers on how to shift Climate Assemblies from technically based deliberations that belong to climate change experts to multi-stakeholders deliberations based on solving the dilemmas from a bottom-up, more societal and value-based perspec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pathogen Oriented SNARE Trafficking for Immune Tailoring' in the context of a Horizon 2020 call.

assistant: **Objectives**

ImImmune clearance of infectious diseases requires correct T cell activation by macrophages and dendritic cells (DCs) that present peptides derived from ingested pathogens on major histocompatibility complexes (MHC). Yet, macrophages and DCs also ingest self-antigens present in healthy cells and their presentation might trigger autoimmune disease. Presentation of the minority of ingested pathogens is promoted by so-called phagosome-autonomous trafficking. Here, pathogen binding to Toll-like receptors in phagosomes triggers recruitment of proteases and transporters to these phagosomes, but not to other phagosomes present in the same cell, promoting specific presentation of pathogen-derived peptides. However, a molecular understanding of this pathogen-oriented phagosome-autonomous trafficking is lacking.The goal of this project is to determine how phagosome-autonomous pathogen recognition promotes presentation of pathogen-derived over harmless self-antigens. Based on my preliminary data and literature, I hypothesize that Toll-like receptor signaling triggers phosphorylation of multiple SNARE proteins at the phagosomal membrane. As SNARE phosphorylation can promote or prevent membrane fusion, this alters delivery of proteases and transporters to these phagosomes, which in turn promotes presentation of pathogen-derived peptides. Objective 1 is to determine how SNARE function is altered upon pathogen-recognition in phagosomes using my novel quantitative Förster resonance energy transfer-fluorescence lifetime imaging microscopy (FRET-FLIM)-based technique. Objective 2 is to address how Toll-like receptor-mediated SNARE phosphorylation affects phagosome-autonomous trafficking. Objective 3 is to resolve the functional roles of SNAREs in antigen presentation using a novel bio-or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Application of complete affine invariants and pose determination for 3d intensity data, in geometric problems of 3d computer vision', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

We deal with the problem of designing algorithms for automatic recognition of threedimensional objects by digital machines. Our approach is the formation of numerical features which remain invariant with respect to viewpoint changes. Within a HCM fellowship recently carried out, we could improve in several directions existing results for the special case of 3D intensity images (completeness, independence and orthogonality of the invariants). We propose applying these results to geometric problems of 3D Computer Vision. It is expected that our approach will minimize the requirements for projection views and search for corresponding points in several instances of geometric 3D Computer Vision.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European clinical research infrastructures network - reciprocal knowledge programme' under Sixth Framework.

assistant: **Concept**

Based on the interconnection of national networks of Clinical Research Centres (CRC) and Clinical Trial Units (CTU) in Denmark, Germany, Italy, Spain, Sweden, and France, together with the European Forum for Good Clinical Practice, the European Clinical Research Infrastructures Network (ECRIN) programme aims at developing an Infrastructure allowing for bottom-up harmonisation of support, training and practice of Clinical Research, and providing public or biotechnology SME sponsors with a support for translational research and multicentre clinical studies in Europe. This will be achieved through an application to the next FP6 'Integrated Infrastructure Initiatives' I3 call, in March 2005. However, previous work is required to improve the reciprocal knowledge between partners in the ECRIN consortium. This is the purpose of the present ECRIN-Reciprocal Knowledge Programme (RKP). A first-step comparative workshop with restricted attendence (3 per network) will be prepared within the national networks, then organised in Brussels (dec 16-17th). Members of CRC/CTUs from countries not yet connected, and speakers involved in GCP, Ethics and Gender Issues will also be invited. The programme will cover the organisation of CRC/CTUs, of national networks, and their interaction with the national environment of clinical research, allowing for an in-depth discussion addressing the bottlenecks hampering transnational studies. A descriptive and comparative analysis will then be discussed at a second-step Closure Meeting organised in Brussels (Feb 14-15th). In addition, members of CRC/CTU located in other countries, and stakeholders involved in European Clinical Research will be invited to discuss this comparative picture of CRC/CTU. This will lead to a Final Report, published and availab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Career development of international talents of the energy research fields in the Iberian Peninsula' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Talent4Iberia Programme aims to promote research excellence in the Iberian Peninsula, with primary focus on the Extremadura Ecosystem of Science, Technology and Innovation (SECTI), by offering 10 interdisciplinary and inter-sectoral fellowships with a duration of 36 months for the mobility and training of postdoctoral researchers of any nationality to develop R&D activities in the field of energy storage in Extremadura, within the Spanish-Portuguese and international cooperation framework, with the purpose to promote the development of their professional careers in an exceptional research environment.Talent4Iberia will be promoted and coordinated by the Council of Economy, Science and Digital Agenda of the Autonomous Community of Extremadura, Spain, the unit with competences in research policies and programmes in the region. The programme will be implement by 3 Spanish recruiting institutions: the Foundation FUNDECYT Science and Technology Park of Extremadura - Iberian Centre for Research in Energy Storage (Fundecyt-CIIAE), the University of Extremadura (UEX) and the Centre for Scientific and Technological Research of Extremadura (CICYTEX), and will count with the participation of 21 associated partners (13 universities, 4 research centres, and 4 companies dedicated to the energy sector, from 15 different countries: 8 EU Member States (Spain, Estonia, Finland, Germany, Italy, Portugal, Slovenia, Sweden), 1 HE Associated Country (Norway), and 4 Other Third Countries (Australia, Chile, Switzerland, United Arab Emirates).The project is aligned with one of the research lines selected as a priority in the participants' policies, ENERGY STORAGE. With an international and interdisciplinary conception, it will also contribute positively to the development of territories with a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'New chemical platforms for targeted radiopharmaceuticals based on generator-produced metal isotopes' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Targeted radiopharmaceuticals for diagnosis and therapy are important in the development of a personalised medicinal approach in oncology. The radiometal isotopes, Ga-68, Tc-99m and Re-188 are particularly useful as they are sourced from a generator and their decay properties are amenable to PET diagnosis, SPECT diagnosis and radiotherapy respectively. This project aims to develop new radiochemical platforms for these isotopes, expanding their utility in nuclear medicine. For Tc-99m and Re-188, multivalent bifunctional chelators will be synthesised, which will be conjugated to the bone cancer targeting group, bisphosphonate, or an analogue of the melanoma targeted peptide, alpha-melanocyte stimulating hormone (aMSH). The new radiolabeled tetravalent compounds will be assessed for targeting efficacy using in vitro and in vivo models. Furthermore, in vivo experiments will determine whether any enhanced tumour accumulation for aMSH-derived multivalent tracers radiotracers (relative to analogues of lower valency) is truly a multivalent effect or a result of prolonged bioavailability. In the case of Ga-68, a novel pretargeting, “reverse-multivalent” approach will be developed, with the aim of decreasing radiation present in non-target organs. This requires multiple copies of a chelating group to be attached to a targeting agent, in this case, an aMSH analogue. This unlabelled agent will bind to the target receptor in vivo prior to injection of a Ga-68 formulation. Complexation of the radiometal at the in vivo target site will be achieved through incorporation of a chelating group that demonstrates high affinity and rapid binding for Ga3+. These new radiochemical platforms for generator-produced isotopes will be developed with a view to clinical translation in the multidiscip
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The research, training and mobility programme in Trentino' under Seventh Framework.

assistant: **Concept**

Trentino is the right bay for research and development. It hosts a large number of research labs from environmental studies to high-tech technologies. The Province of Trento allocates several resources such as infrastructure, real estate and funds to encourage research and innovation. Many institutes, both public and private, local, national and international have established their research units in Trento and Rovereto in order to transfer the knowledge from the research arena to industries. In order to facilitate the development of the research environment the PAT decided to start its Research Mobility programme.  The Trentino programme started in 2003 with the first call for proposals for incoming research post-docs and implemented in 2006 with the call for proposals for Research Teams. The general objective of this proposal is to increase the number of trans-national fellowships awarded, to introduce a new outgoing and reintegration scheme and to improve the fellows’ condition. Thanks to the COFUND action the number of researchers coming from outside Italy could be increased and the local/Italian researchers be reintegrated. Besides, some researchers could profit of international experiences and then come back to Trentino.  Furthermore the conditions of the fellows will be improved by promoting the implementation of the conditions described in “The European Charter for Researchers and The Code of Conduct for the Recruitment of Researchers”, in particular by offering employment contracts instead of stipends to the fellows, by establishing a career development plan at the beginning of the project and by introducing an assessment questionnaire at the end of the project. Another objective is to improve the Internet website and its English version.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New Organic Semiconductor Device Concepts', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The goal of the present project is to investigate novel device concepts based on organic  semiconductor materials: the number of device principles is still rather small for organic devices and many concepts are not explored. The concept of controlled molecular doping successfully introduced to optoelectronic devices will be used here to achieve Fermi level control and  well-defined junctions. Preferentially, we plan to work in this project with oligomer substances which are deposited by vacuum technology. The main reason for this choice is that this approach allows depositing multilayer structures with comparatively high reproducibility. However, the principles developed here should also applicable with other low-cost deposition technologies such as printing. Based on previous experiments such as the realization of the first pn-homojunction, this work will concentrate on the following devices: First, we want to further develop the Zener diodes which have in first experiments shown that the basic effects exist in organic devices as well. The goal is to significantly reduce the forward offset voltage and the improve controllability of the reverse breakdown voltage. Second, we want to try to realizeefficient triodes allowing larger currents and higher switching speed as conventional approaches. Furthermore, we strive to realize an organic bipolar transistor, which is challenging in organic devices due the rather small diffusion lengths. Third, we will approach new devices with more complex layer structures, such as thyristors. While certain device types will be in the focus of the projects, we expect that the general understanding of organic semiconductors in switching device applications can be improved.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Search for New Physics in Charm at LHCb', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The unique capabilities of the LHCb experiment at CERN will be used to collect enormous samples of charm meson multibody decays, and then study these decays for evidence of indirect CP-violation.  Any discovery would be highly suggestive of physics contributions from beyond the Standard Model.   The analysis methods proposed are novel and are largely independent of model-based assumptions about the resonance substructure of the charm decay, hence providing robustness to the results.  The proposal also features plans to improve the trigger system of LHCb to improve still further the performance in charm physics during future data taking