RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Revolutionary embedded memory for internet of things devices and energy reduction'.

assistant: **Innovation**

REMINDER aims to develop an embedded DRAM solution optimized for ultra-low-power consumption andvariability immunity, specifically focused on Internet of Things cut-edge devices. The objectives of REMINDER are :i) Investigation (concept, design, characterization, simulation, modelling), selection and optimization of aFloating-Body memory bit cell in terms of low power and low voltage, high reliability, robustness(variability), speed, reduced footprint and cost.ii) Design and fabrication in FDSOI 28nm (FD28) and FDSOI 14nm (FD14) technology nodes of amemory matrix based on the optimized bit-cells developed. Matrix memory subcircuits,blocks and architectures will be carefully analysed from the power-consumption point of view.In addition variability tolerant design techniques underpinned by variability analysis and statisticalsimulation technology will be considered.iii) Demonstration of a system on chip application using the developed memory solution andbenchmarking with alternative embedded memory blocks.The eventual replacement of Si by strained Si/SiGe and III-V materials in future CMOS circuits would alsorequire the redesign of different applications, including memory cells, and therefore we also propose the evaluationof the optimized bit cells developed in FD28 and FD14 technology nodes using these alternativematerials. The fulfilment of the objectives above will also imply the development of:i) New techniques for the electrical characterization of ultimate CMOS nanometric devices. This willallow us to improve the CMOS technology by boosting device performance.ii) New behavioural models, incorporating variability effects, to reach a deep understanding ofnanoelectronics devicesiii) Advanced simulation tools for nanoelectronic devices for state of the art, and emerging
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Genetics of mitral valve prolapse' (MVP-GEN).

assistant: **Innovation**

Background:  Mitral valve prolapse (MVP) is one of the most common valvular heart disorders. Twenty percent of MVP patients will develop severe complications, including congestive heart failure, endocarditis, atrial arrhythmias, embolic events and even sudden death.  MVP is the most common cause of mitral regurgitation requiring surgical repair, however, very little is known about its etiology. MVP has a strong genetic background with significant heterogeneity.  Previous genetic studies have shown that non-syndromic MVP can be caused by mutations in filamin A, and the applicant’s  group has identified two additional genetic loci, MMVP2 and MMVP3, on chromosomes 11 and 13. In this study we propose to identify the gene for MMVP2 using next-generation sequencing analysis, and to analyze additional families to further define the molecular pathways that lead to the development of MVP.Aims: The aims of this proposal are to 1) identify the gene for MMVP2 using next-generation sequencing and 2)  identify MVP-causing mutations in families segregating the disease by whole-genome family-based linkage analysis, positional cloning and parallel sequencing.Methods: A DNA library representing MMVP2 locus of 4 affected individuals was already prepared and will be sequenced. After sequencing we will validate potential mutation by replicating in  nearly 200 familial and sporadic MVP cases. Newly recruited families segregating MVP will be queued for a whole-genome linkage analysis to identify MVP susceptibility loci. DNA of the targeted regions in affected individuals will be pooled and sequenced using next-generation parallel sequencing in search for sequence variation. The pathogenicity of sequence variations will be determined by verifying  their segregation with disease in the pedigree
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Refinery integration, scale-up and certification for aviation and marine biofuels production' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Among solutions to reach an EU net zero emissions economy by 2050, advanced biofuels have the potential to save several gigatons of CO2 emission per year. However, their development is hampered by a complex feedstock to be processed, the massive investments needed for each new refinery unit, the lack of certification for market adoption and above all, social acceptance of the biofuel production itself.REFOLUTION will tackle these limitations by delivering a cost-effective production (reduction of CAPEX by 50% and OPEX by 45%) of advanced biofuels for the aviation and marine sectors via a process that can be implemented in existing European refineries. REFOLUTION will demonstrate the transformation of bio-oils produced from fast pyrolysis (FP) into advanced biofuels, through intermediate process steps (stabilisation, fractionation) combined with downstream co-processing technologies at different levels of severities (temperature, hydrogen consumption, carbon yield) for targeting different applications: Fluid Catalytic Cracking (FCC) co-processing for aviation (TRL7) and marine sectors, and hydrotreating for marine (TRL6).REFOLUTION is gathering 14 leading EU entities covering the full biofuel value chain to deploy risk-mitigation pathways for successful implementation into existing refineries. The project will deliver a comprehensive toolbox of models, standards, social assessment and exploitation pathways for interfacing with current refinery models and available documentation for further replication in other existing refineries, from a dozen in 2030 several hundred pyrolysis units delivering bio-feedstocks to the 90+ refineries in 2050.


**Keywords:** biofuel; refinery; fast pyrolysis; Fluid Catalytic Cracking; co-hydrotreating; aviation; marine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Seafloor spreading on Short And Long Time scales' (SeaSALT) under Horizon Europe.

assistant: **Objectives**

Seafloor spreading is the process that single-handedly shapes 2/3 of our planet, modulates the dynamics of deep ocean currents, controls the composition of seawater, and supports unique ecosystems that thrive in extreme environments. Discovered in the 1960s, it is now explained as the slow and steady divergence of 2 tectonic plates accommodated by magma emplacement and faulting at a mid-ocean ridge axis. In the current paradigm, the texture of the seafloor is primarily determined by the magmatically-accommodated fraction (M) of plate separation at the ridge axis. However, we do not know what sets the M fraction in the first place, and why it is subject to spatiotemporal fluctuations that can cause drastic shifts in seafloor spreading regimes. SeaSALT tackles this issue by rethinking seafloor spreading as a succession of discrete magmatic and tectonic events which, by inhibiting or triggering one another, self-consistently distribute magmatic and tectonic strain. To test this hypothesis, we will design brand-new simulations of seismo-volcanic cycles in which dike intrusions, earthquakes, or aseismic slip transients may occur in response to far-field extension and pressurization of a shallow magma reservoir. Each component of the model will be constrained by groundbreaking observations of seafloor spreading events and inter-event stress build-up at 3 target sites. This includes  the most ambitious seafloor seismo-geodesy experiment to date across a ridge axis, and the development of a novel hydrothermal geodesy method that constrains sub-seafloor stress changes via the perturbations they impart on black smoker temperatures. The success of our new framework will be indexed on its ability to spontaneously generate the types of events documented at each site, while accountin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Women’s Economic and Psychological Empowerment' (EMPOWER).

assistant: **Innovation**

Women’s Economic Empowerment has become a mainstream gender and development policy and practice. UN Women states that “investing in women’s economic empowerment sets a direct path towards gender equality, poverty eradication and inclusive economic growth”. But as leading gender and development academics ask, is it really that simple? In the light of gender inequalities worldwide, feminist economists and gender and development experts, demand a more nuanced understanding of transformation processes. The Women’s Economic and Psychological Empowerment- EMPOWER project brings together feminist economics, gender and development, and social psychology to understand how to ensure personal empowerment processes through the promotion of women’s access to productive resources in specific contexts. EMPOWER will answer the research question for which women, with which economic activities and in which contexts can access to productive resources allow for economic and social transformations that lead to women’s psychological empowerment. EMPOWER aims to look at the psychological empowerment process in relation to programmes that target to give women access to different economic resources with a critical analysis of how development programmes work, engaging insight from academia as well as insights from gender and development policy. I will be hosted by CARE Netherlands, one of the major non-academic international organisations in the development sector that has an extensive database of women’s empowerment programmes with the aim of creating gender transformative change across different geographic and socio-political settings. Furthermore, I will carry out a secondment at the International Institute for Social Sciences, a major European academic institution of policy-oriented social s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Modeling, Control and Management of Thermal Effects in Electronic Circuits of the Future' (THERMINATOR) targeting Seventh Framework.

assistant: **Abstract**

Electronic devices of the latest generations, being those integrated circuits or discrete components, are often required to operate in harsh environmental conditions, where the temperature may reach over hundred degrees centigrade. Obviously, this has negative impact on several parameters of the electronic devices, ranging from slow-down and transient, recoverable errors to permanent failures and device breakdown. To complicate the picture, electronic components tend to get warmer on their own as they operate, due to the fact that the power drawn by the devices from the power supply is dissipated by Joule effect.<br/>As time passes, heat and temperature management is becoming increasingly problematic, for reasons ranging from economical to technological. Packages that are able to sustain high temperatures are very expensive, and so are heat-sinks and cooling systems. In addition, high operating temperatures tend to cause malfunctioning of circuits and components, thus impacting the reliability of the electronic products which incorporate such devices.<br/>The development of new, thermal-aware design paradigms can no longer be postponed if the goal is to enable designers to fully exploit the electronic technologies of the future, being those CMOS or alternative to CMOS.<br/>The thermal problem has several facets, thus it needs to be addressed in a comprehensive manner.  The THERMINATOR projects will address the following major challenges: 1) To devise innovative thermal models usable at different levels of abstraction, and to interface/integrate them into existing simulation and design frameworks. 2) To develop new, thermal-aware design solutions, customized for the different technologies and application domains of interest. 3) To enhance existing EDA solutions by means
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Intravital optical super-resolution imaging in the brain' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Synapses are small, highly specialized structures of intercellular contact that play a crucial role in neuronal information processing and memory. While traditional fluorescence microscopy is an extremely powerful tool to study the dynamics of biological processes in vivo with molecular specificity, it has insufficient resolving power to dissect details of synaptic structure and functional organization or the structure of small subcellular components. In contrast, far-field optical super-resolution techniques provide spatial resolution at the nanoscale beyond the limit imposed by the diffraction of light. However, current super-resolution techniques are limited to thin brain preparations or to the surface of thick samples. The central aim of this proposal is to establish optical super-resolution methods for imaging chemical synapses in all layers of the cerebral cortex and in deep lying structures of the brain and to apply these techniques to timely questions in neurobiology. We will develop intravital super-resolution microendoscopy based on the stimulated emission depletion (STED) technique. This will enable intravital microscopy of arbitrary brain regions with diffraction-unlimited resolving power. In addition, we will miniaturize the setup, opening up the investigation of nanoscale structures in the brain of awake, freely moving and behaving animals. With this, we will be able to correlate for the first time synaptic structural or organizational plasticity at the nanoscale with behavioural stimuli in a living animal, including for instance in the hippocampus of an animal exposed to a learning situation. Furthermore, these methods will advance the understanding of the interplay between neurons and glia, in particular at synapses, and will help to shed light on brain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Increasing Resilience through Earth Observation' (IncREO), addressing dissemination and exploitation.

assistant: **Impact**

The overall objective of IncREO is to provide actors responsible for disaster management, risk prevention, civil protection and also spatial planning with EO-based solutions contributing particularly to an improved preparedness and mitigation planning for areas highly vulnerable to natural disasters and already noticeable climate change trends. These solutions will be adjusted to the users’ and end-users’ needs and will also reflect on short-term climate change scenarios and related legislature – both on national, supranational and European level. As a multi-risk oriented concept per se any type of natural disaster is addressed. However, selected use cases (dam failure, storm surge and wave height, flood, earthquake and landslide) and the transfer of solutions to a specifically multi-risk prone test site will also be covered. From a technical point of view the IncREO solutions will be based on state-of-the-art methodologies, implemented by means of up-to-date mapping and modelling / procedures and finally appropriately disseminated to the relevant stakeholder groups.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'PERovkite Stability and Optoelectronic Properties Assessment at the Steady State'.

assistant: **Innovation**

Halide perovskites solar cells are asserting themselves as possible alternative to the currently dominating Silicon based ones. Their low-cost, ease of production and the high power-conversion efficiency make them promising candidates for the next generation of solar cells. In the project PERSOPASS I will address the issue that most critically impede the advent of halide perovskite solar cells in the market: stability. Results on this subject are sparse and the reproducibility between groups is scarce. This is due to the significant influence of composition variations on perovskite properties and, also, to the lack of control of the precise (ppm) composition. I will use a straightforward microfluidic based strategy in which the composition of halide perovskite crystals is set by the contact with continuously flowing precursor or dopant solutions. Reaching a steady state, any dependence on the fabrication process will be removed. The specific configuration of this project will allow me to assess a large number of precisely controlled compositions in parallel. Together with the ability to characterize the optoelectronic properties on a microscopic scale, this experimental platform enables the drawing of a correlation between variation of composition and stability as well as doping. The hosting laboratory IPVF is a global leader in the development of advanced characterization methods with an outstanding expertise on hyperspectral luminescence and time-resolved fluorescence imaging, which will be extensively used during the action. I will contribute my expertise in microfluidics and on the self-healing chemical properties of halide perovskites. Beyond purely scientific objectives, this project also aims to provide industrially relevant strategies for damage mitigation which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Global Mapping of Synthetic Genetic Interactions in Drosophila' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The genetics underlying phenotype-genotype relationships during development and disease is often complex with many genes contributing to a particular phenotypic outcome. While forward genetic screens have uncovered many mutations that are limiting at a particular stage or tissue, the majority of genes in most genomes remain genetically untouched. Recent studies in model organisms, in particular in yeast, have provided evidence for the existence of pervasive genetic interactions with large effects on many phenotypes. Such genetic factors have been rather difficult to identify in classical loss-of-function screens due to buffering and other compensatory mechanisms, therefore requiring novel methodological approaches.The systematic analysis of synthetic genetic interactions also revealed how biological systems achieve a high level of complexity with a limited repertoire of components. Large-scale studies yeast have taken advantage of deletion strains to construct matrices of quantitative interaction profiles and infer gene function. However, comparable approaches in higher organisms have been difficult to implement in a robust manner.We here propose to create the first systematic synthetic genetic interaction map of a metazoan cell.  Based on methods that we recently pioneered, we will quantitatively measure genetic interactions between genes on a genome scale using Drosophila cells as a model. We will utilize the map to globally dissect the interaction between processes with a focus on signaling networks.  Furthermore, we will follow-up on selected interactions by in-depth characterization.  Synthetic genetic interactions will be further analyzed in vivo in tissues to complement the cell-based approaches. The project will advance new experimental and computational approac