RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Programme for advanced supply chain modelling and optimisation', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

This proposal outlines a programme to develop a world-class expertise in Supply Chain Modelling and Optimisation in Ireland, based in University College Dublin (UCD). UCD is the largest university in Ireland, and has a very strong track record in EU Frame work Programmes, and particularly in Marie Curie TOK schemes. The productive interface of a knowledge economy such as Ireland involves basic research within the Universities and other research centres being linked to the needs of industry, both foreign owned and indigenous. We have identified within Irish industry a pressing need for supply chain expertise, a need that is mirrored throughout Europe. This proposal will provide UCD with the resources to make a strategic improvement by creating a viable centre of excellence for supply chain research. It is proposed that supply chain modelling and optimisation competencies be developed through a programme of visiting researchers working with staff from the National Institute of Technology Management (NITM) i n UCD, and secondments of UCD staff to expert partners. The knowledge transferred from visiting researchers will be absorbed by interdisciplinary research teams, and disseminated through teaching, industry liaison, academic conferences and publications. T his proposal envisages a unique combination of interdisciplinary researchers working to develop valuable expertise in supply chain modelling and optimisation throughout Europe. It also encompasses innovative technology transfer mechanisms for disseminating the knowledge to industry, particularly to SME's. While this proposal primarily contributes to the 6th Framework Programme by strengthening the scientific and technological bases of industry, it also promotes research activities in support of other EU policies. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Aid from Islamic Donors in conflict zones' (ISLAMICAID).

assistant: **Innovation**

ISLAMICAID has the overall objective to provide a broader understanding of humanitarian aid in conflict zones as implemented by Islamic actors and improve the dialogue between Western and Gulf donors. The Action has two specific objectives. One is related to Islamic social welfare instruments and their contribution to social protection and economic empowerment. The second concerns the foreign aid of Saudi Arabia, Qatar, and the UAE and the implementation through different channels, including charity organisations. These two objectives will consider interventions in three conflict zones, such as Yemen, Sudan, and Syria, from 2015 to 2022. The necessity to enhance the coordination of aid interventions and expand the resource base for humanitarian financing makes this research relevant in terms of timing and scope. The Action aims to contribute to the DG ECHO Humanitarian Logistics Policy, which promotes effective coordination with other humanitarian organisations in complex crises. Not only does the research fill the gap in the literature, but it also analyses aid practices from a top-down and bottom-up approach with an anthropological perspective through fieldwork and ethnographic research, which will produce new evidence of Islamic financing instruments, Gulf donors' decision-making process, and everyday humanitarian negotiation practices of organisations in the field. Through the collaboration between UNIVE and Princeton University, and the supervision of Prof. Legrenzi and Prof. Haykel, the MSCA will allow me to expand my previous study on Islamic aid practices, receive training in anthropology, ethnographic research and social network analysis, and become an expert in Gulf donors and humanitarian financing in conflict zones. I will productively engage with the US aca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Alpine lakes benthic viral community structure and diversity: a metagenomic and ecological approach' (2014-2020).

assistant: **Concept**

Viruses are a key and yet neglected component of freshwater ecosystems. By impacting bacterial communities they influence evolutionary dynamics, mineralisation processes, energy transfer across trophic levels and greenhouse gas emission. Nonetheless, they are among the least understood organisms.This project proposes a multidisciplinary breakthrough combining metagenomics, microbiology, and advanced computation to characterise the genetic diversity, structure and function of viral and bacterial communities in freshwater sediments along an altitudinal gradient that mimics a natural temperature gradient. As model system I will use the threatened Alpine lakes; the ultimate aim is to develop a model that could predict the response of benthic microbial communities to future climatic changes.Three steps are involved:1)an experimental microbiology approach will describe the viral community structure and evaluate the viral contribution to bacteria mortality and C-cycle; 2)an experimental and computational metagenomics approach will define the genetic structure and diversity of the viral and microbial benthic community and 3)statistical modelling of the effect of temperature and other biochemical factors on viral community structure and genetic diversity, virus-host interactions and benthic C-cycle.To date, no investigations combined microbiological and metagenomics approaches to characterise microbial communities in freshwaters. This project will provide unprecedented insights into the potential effects of global change on threatened Alpine lakes, with important conservation implications across EU Countries.During this multidisciplinary project I will train intensively in bioinformatics, limnology and project management, exchanging knowledge with world leaders in the field of m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Investigating the function of the microsporidian mitosome using genomics and molecular cell biology' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Microsporidia like Trachipleistophora hominis and Encephalitozoon cuniculi, are opportunistic parasites of humans with HIV. Around 50% of cases of serious diarrhoea in AIDS patients are associated with microsporidia - 14 different microsporidia have now been isolated. Despite their importance, the genome and cell biology of microsporidia are poorly understood. I will use a multidisciplinary approach incorporating training in bioinformatics, proteomics, cell and molecular biology to investigate the structu re and function of the recently discovered microsporidian mitosome ' the most highly reduced mitochondrion yet discovered. My work will also further basic understanding of the minimal and essential functions of the mitochondrion itself; an organelle that is vital for eukaryotes. My hypothesis is that the mitosome makes iron sulphur (Fe-S) clusters ' a fundamental process for all eukaryotic cells, and whose dysfunction causes inherited mitochondrial diseases like Friedrichs Ataxia. The E. cuniculi genome en codes seven of the proteins involved in this process, but there is no experimental data on their location or function. I will clone and sequence two of the key genes (Nfs1p, Isu1p) from Trachipleistophora hominis, a more tractable experimental system than Encephalitozoon, and produce antibodies to locate their site of activity. I will also perform in vitro tests of enzyme function. I will do this at Newcastle University with Professor Martin Embley, in whose lab the mitosome was discovered, and where there are state-of-the-art facilities for bioinformatics, cell biology, proteomics and light and electron microscopy. I will also use bioinformatics to search the Encephalitozoon genome for the mitosomal import pathway. Preliminary data suggests that the mitosome may hav
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mechanisms of Cellular Rigidity Sensing' under Seventh Framework.

assistant: **Concept**

Recent studies show that the rigidity of the extracellular matrix is a critical determinant of cell growth, differentiation, and death. Cells sense rigidity via integrin adhesions and respond by changing their morphology, signaling, and gene expression patterns. Irregular rigidity signals or defective responses to appropriate rigidity signals underlie many medical disorders. This is especially evident in cancer, where the ability of cells to detect differences in matrix rigidity is fundamentally altered. Despite the importance of mechanosensing of matrix rigidity, findings in this field have been mainly phenomenological, and at the moment we still don’t know how rigidity sensing occurs.Active rigidity sensing involves development of traction forces on integrin adhesions, yet how cells develop forces, and how these forces are used to sense and transmit rigidity signals are both unknown. This grant is focused on analyses of the steps in building the machinery used by fibroblasts to sense and transmit rigidity signals. During the outgoing phase of the studies the applicant will use a combination of nanofabricated surfaces with integrin ligands, elastic micropillars that allow measuring forces, and super-resolution microscopy to define the critical steps in the assembly of integrin adhesions and to determine which proteins are essential for force production. The return phase of the studies will focus on investigating the signaling events downstream of rigidity sensing using biophysical measurements of the interaction kinetics of signaling molecules with integrin adhesions. The proposed studies will provide a detailed spatiotemporal description of the critical components and pathways of mechanosensing of matrix rigidity, and will help explain the underlying mechanisms involv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New materials and cell designs for cleaner and more energy efficient production of aluminium in year 2000' to be submitted under Fourth Framework.

assistant: **Abstract**

Primary aluminium production is characterised by high-energy consumption and emissions of greenhouse gases, e.g. CO2 and per fluorinated carbons (CF4 and C2F6). In order to improve the present smelting process, the objectives of this project are to reduce energy consumption by 20 %, to eliminate emissions of CO2 and perfluorinated carbons, and to extend cell life by 3050 % by using non consumable, metallic anodes and aluminium wet table, TiB2 coated, inclined cathodes (drained mode") in new cell designs. The technical and economic feasibility of the no consumable anodes and the TiB2 coating will be investigated on an industrial scale. The long term stability of the anodes and sufficiently low impurity levels in the electro won aluminium have to be demonstrated in industrial cells with TiB2 coated, drained cathodes. During the project, the new materials will be tested in 150 160 kA industrial cells for periods, varying between 6 and 12 months. The new technology will also be tested in modified, commercial cells to demonstrate that it can be adapted to existing smelters (retrofitting).A successful completion of the project will yield the following results: A TiB2 based, aluminium wet table cathode coating, which is abrasion resistant, reduces sodium penetration and can be easily applied to carbon cathodes of any shape or design. Prototypes of and method to manufacture industrialise, non-consumable anodes Design, construction and operation of new industrial cells with drained TiB2coated cathodes and / or non-consumable, metallic anodes. This project brings together four organisations from different European countries in one consortium, consisting of a manufacturer (HER), an aluminium producer (HOOG), a research organisation (ENEA) and a technology developer (MOL), to reali
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Lymph node homing of immune cells via afferent lymphatics – mechanisms and immune response'.

assistant: **Objectives**

The continuous migration of immune cells to lymph nodes (LN) is of utmost importance for the induction of both protective immunity as well as immunological tolerance. Despite this pivotal role, little is known regarding migration paths and the molecular cues regulating homing of immune cells that arrive via afferent lymphatic vessels to LN. This conspicuous lack of knowledge is primarily due to profound technical limitations. My team and I have recently developed a highly innovative technique of micromanipulator-guided injections into afferent lymph vessels that drain into the popliteal LN of living mice allowing precise delivery of very low numbers of cells into a LN. This approach, in combination with multicolor 2-photon in vivo microscopy, will now allow new and ground-breaking insights in routes, cellular and molecular mechanisms that regulate entry of cells reaching LNs via afferent lymphatics. Specifically, we aim to 1) characterize the homing potential of lymph-derived naïve B cells, naïve CD8 T cells, and regulatory T cells and study their contribution to LN homeostasis; 2) initiate and quantify primary immune responses to model antigens as well as pathogens mediated by naïve T cells that homed to LN via afferent lymphatics; 3) characterize memory immune responses mediated by different subpopulations of effector/memory cells that homed to LN via afferent lymphatics; 4) study the role of neutrophilic and eosinophilic granulocytes in adaptive immune responses; 5) identify homing molecules and mechanisms that allow DCs and metastasizing tumor cells to penetrate the floor of the LN subcapsular sinus.Results obtained from these studies will provide fundamentally new insights in processes that regulate immune cell homing to LN and the induction of primary and recall m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Innovative Technique for Large-Scale Production of NANO COATINGS to Reach Global Market of Synthetic Diamond', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The world’s synthetic diamond market production reached 4.42 billion carats (> 800 million €) in 2015 compared with 60 million carats of natural industrial diamond. Transparency Market Research also reports that it is expected to experience a growth of nearly 100% in the next eight years, reaching 26.9 billion € by 20233. However, to reach this estimations there is a need to face the challenges existing today to commercialise synthetic diamonds.In this context NanoCoatings a technological Company supported from 2014 by the Spanish Ministry of Science and Innovation is working to industrialise an innovative and environmental-friendly technology, L-CVD (Patent Appl. EP 16382414.7) solution which enables the high speed (80µ/h), cheap and large-scale production of synthetic diamond in the world  .  Our present objective is to go from a small-scale prototype (1,99Cts/day) to 6,57Cts/day  in 2019, a required step to ensure industrialisation and standardisation of the large scale production. The work plan proposed by NC will accelerate the innovation process by up-scaling a single reactor and adapting an optimized automation of the process (one rector and 4 reactors working continuously with 26,28Cts/day). This technological upgrades are crucial to meet expected retail prices and to ensure to European manufactures a large stock of synthetic diamond in Europe.Besides, NC will work in the market implementation, and will perform tests for the demonstration of the produced synthetic diamond in products of the coatings, electronics and jewellery. By 2023, expects an accumulated turnover of 3.7 million € that will allow a payback period of 4.4 years and a Return of Investment of 55%.


**Keywords:** synthetic diamond
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'On the role of the Southern Ocean carbon pump in the regulation of atmospheric carbon dioxide concentrations', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The cause of glacial/interglacial (G/IG) variations in atmospheric carbon dioxide concentrations remains among the most important unresolved challenges in Earth sciences. Recent modelling studies suggest that the ultimate explanation of the full G/IG atmospheric CO2 change relies in a combination of physical and biogeochemical processes that are involved in the regulation of the deep ocean carbon reservoir. The Southern Ocean (SO) ventilates the largest fraction of the deep ocean, and represent the biggest open ocean region where the extraction of nitrate and phosphate by marine phytoplankton is incomplete, allowing for the leakage of deeply sequestered carbon back to the atmosphere. Consequently, an increased SO nutrient utilization during glacial stages has been proposed as a plausible mechanism to increase the efficiency of the ocean’s biological pump that could explain the lower atmospheric CO2 levels during ice ages. Recent estimates of the nutrient status of the glacial SO using a newly developed technique based on the analysis of the isotopic composition of nitrogen bound within microfossil shells (and hence potentially free of sedimentary artefacts), have offered promising new insights on the spatial and temporal response of nutrient consumption in the Antarctic region during glacial stages. However, the available microfossil-bound dataset is limited to the last glacial cycle and far too sparse to provide a clear picture of the nutrient status of the SO during ice ages. This proposal seeks to provide key constrains on this mechanism by applying a multidisciplinary approach that combine (i) the generation of new G/IG microfossil-bound N isotopes records from previously unexplored regions of the SO; (ii) its extension back in time beyond the last glacial stage; an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'AMBER - enhAnced Mobile BiomEtRics'.

assistant: **Innovation**

Over recent years the ubiquity of mobile platforms such as smartphones and tablets devices has rapidly increased. These devices provide a range of untethered interaction unimaginable a decade previously. With this ability to interact with services and individuals comes the need to accurately authenticate the identity of the person requesting the transaction many of which carry financial/legally-binding instruction. Biometric solutions have also seen increased prominence over the past decade with large-scale implementations in areas such as passport and national ID systems. The adoption of specific biometric sensors by mobile vendors indicates a long-term strategy as a means of authentication. This adoption is is at critical point – users need to be confident of biometrics in terms of usability, privacy and performance; compromise in any one of these categories will lead to mistrust and a reluctance to adopt over and above conventional forms of authentication. The design, implementation and assessment of biometrics on mobile devices therefore requires a range of solutions to aid initial and continued adoption. The EU needs to have experts trained specifically in the field to ensure that it participates, competes and succeeds in the global market. AMBER comprises 11 partners with recognised expertise from across the EU. The specific objectives are to:• Address a range of current issues facing biometric solutions on mobile devices requiring timely research and development.• Collate Europe-wide complementary expertise to investigate these issues and provide a structure and environment to effectively facilitate training.• Train and equip the next generation of researchers to define, investigate and implement solutions, and provide transferable skills to enable effective plan