RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developing and implementing VIrtual Control groups To reducE animal use in toxicology Research' (VICT3R) targeting Horizon Europe.

assistant: **Abstract**

VICT3R, a public-private partnership running under the European Innovative Health Initiative, aims to significantly reduce the number of animals used in experimental studies performed during the nonclinical drug and chemical safety evaluation by replacing the animals of the concurrent controls groups (CCGs) with Virtual Control Groups (VCGs). These VCGs will be generated by means of state-of-the-art statistical or artificial intelligence (AI) approaches that optimally exploit the wealth of historical data from control animals accumulated over decades by pharmaceutical companies and other relevant industrial and academic sectors. The VCG concept was conceived and prototyped during the recently finished eTRANSAFE IMI2 project for its application in the nonclinical safety assessment of the pharmaceutical industry. A preliminary evaluation of the VCG concept carried out in the eTRANSAFE project demonstrated that it is generally feasible, yet scientifically and operationally challenging and must therefore be refined before its adoption for regulatory hazard and risk assessment. The main challenges consist of adequate data collection and curation, identification of key variables to achieve optimal matching between VCGs and CCGs, and validation of procedures including compliance with Good Laboratory Practice (GLP). These challenges will be systematically tackled in VICT3R for achieving the full development and regulatory acceptance of the VCG concept. VICT3R will collect, curate and analyse large data sets of control animals from different species to produce a large high-quality database. The database will be made available to VICT3R partners, regulators, and policy makers with the purpose to allow maturation of the VCG concept and to prove its validity, reproducibility and ro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Deciphering Membrane Compartmentalization in Protein-Misfolding Bacterial Dysfunction to Re-Sensitize Multi-Drug Resistant Pathogens.'.

assistant: **Innovation**

Multi-drug resistant (MDR) bacterial infections threaten all the advances in modern medicine after the industry nearly abandoned antibiotic development and no mechanism to suppress antibiotic resistance has been found. However, our results indicate that this mechanism does exist and is conserved in functional membrane microdomains (FMM) in all prokaryotes. We discovered bacterial FMM, akin to eukaryotic lipid rafts, and demonstrated their crucial role in preserving proteins correctly folded at no ATP cost. FMM are essential for pathogens survival during infections thus, FMM perturbation causes the bacterial proteome to collapse, particularly affecting heterologous proteins responsible for MDR. This leads to attenuated infections and additionally re-sensitizing MDR pathogens to antibiotics. Studying FMM will transform our understanding of cellular membrane organization and its connection to protein misfolding disorders. Accordingly, this proposal will undertake an ambitious molecular characterization of FMM and its impact on bacterial proteostasis, and we will apply this knowledge to bring closer to the clinic a battery of anti-FMM drugs that target FMM to reactivate antibiotics against MDR infections. To achieve this, a first structural goal will describe FMM molecular organization, how FMM operate to prevent protein misfolding, and the molecular principles driving the assembly of membrane microdomains in cells. Secondly, a functional goal will describe the mechanism of proteome stabilization independent of ATP and its crucial role in pathogenesis. Finally, an applied goal will be to implement anti-FMM drugs to eliminate MDR infections and re-sensitize them to conventional antibiotics. This proposal unveils a new frontier in understanding the cellular programs for membr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Water Distribution Network Efficiency Optimisation with Resilience and Equity Quantification' to be submitted under Horizon Europe.

assistant: **Abstract**

The proposal focuses on addressing critical challenges in water distribution networks (WDN), recognizing its fundamental role as an essential service for society. The WATER-RENEQ approach is a comprehensive methodology that optimizes WDNs by ensuring their response capacity to adverse events (resilience), guaranteeing equity for all users, and maximizing energy savings. The first objective (O1) aims to establish a set of quantifiable indicators and performance indices that measure the operation of WDNs. These indicators will encompass key aspects of resilience and equity while focusing on energy efficiency as a quantifiable metric. Objective two (O2) focuses on the development of an innovative mathematical model. This optimization model will calculate the indices defined in O1 within a WDN. It will provide a practical methodology to evaluate and analyze WDN resilience, addressing both operational aspects and overall system performance. The third objective (O3) targets advancements in the computational efficiency of optimization algorithms. This involves reducing the number of discrete variables and optimizing the overall search space. Improving computational efficiency is crucial for solving complex real-world optimization problems effectively. Objective four (O4) involves the development of an optimization tool that proposes investment strategies for WDNs. The tool's primary goal is to maximize resilience and equity indicators within the network, even when budget constraints are present. This approach aims to provide a robust mathematical framework that considers resilience and equity criteria. In summary, the proposal addresses fundamental challenges facing WDN by introducing an innovative approach to measure and improve resilience, equity, and energy efficiency, deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Clinical validation of the AutArt rheumatoid arthritis diagnostic device' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The AutArt diagnostic toolkit is a medical device that automatically diagnoses the progression of Rheumatoid Arthritis (RA) on an X-Ray image by using the Sharp/van der Heijde scoring system. This Phase 1 feasibility study will support the clinical validation of the device in Phase 2 that we estimate will cost between 1.5-2 million EUR; with the first market sale scheduled within 2 years, sold SAS (Software as a Service). RA is a chronic autoimmune disease that causes inflammation of the lining of the joints, which can destroy cartilage and bone, causing deformity of the joints. RA is a serious economic and social problem, 20-30% of early RA patients become permanently work disabled during the first 2-3 years of the disease and more than 50% of patients with RA became work disabled during the first ten years of the disease. Classical disease-modifying drugs are ineffective in about 10-15% of the cases, furthermore, biologic agents may also be ineffective. Early detection, regular clinical monitoring and comparable, objective evaluation is essential for successful treatment. The AutArt medical device is the result of 2 years of intensive R&D and at the moment there are no serious competitors in the market, so this is the time to act for a dynamically rising market share in the RA diagnostic market. The target group consists of MDs, medical institutions and pharmaceutical companies. The unique selling points of the product are objectivity, comparability and precision.  In the EU, RA treatments cost 25.1 billion EUR in 2009. With more precise diagnosis and objective follow-up this can be decreased considerably with the AutArt medical device. This project is in line with the 282/2014/EU regulation on the establishment of a third Programme for the Union’s action in the field
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Semantic V2X communications: a paradigm shift towards scalable V2X networks'.

assistant: **Innovation**

Vehicle-to-Everything (V2X) communications are key for the transition towards a Connected and Automated Mobility (CAM) that is essential to accomplish the EU Green Deal vision of a safer, more efficient, and sustainable transportation. Like any existing communication system, current V2X communications focus on the reliable and timely transmission of signals without considering the relevance of the transmitted information. Such relevance-agnostic approach can lead to the transmission of unnecessary data that will challenge the scalability of V2X networks, especially in light of the increasing amount of V2X data that will be produced and consumed with the mass-deployment of Connected and Autonomous Vehicles (CAVs). In the SemanticV2X project, we take inspiration from the human language to redesign V2X communications by proposing a paradigm shift that makes the semantics of the information the foundation of the V2X communication process. We will capitalize on the semantic processing capabilities natively available in CAVs to develop a novel set of analytical and numerical semantic models that determine the relevance of the information for the intended receivers considering the target application(s) and leveraging a knowledge-driven representation of the communication context. SemanticV2X will leverage the semantic models to develop a novel semantic and goal-oriented V2X communication paradigm where CAVs curate the transmitted information based on its relevance for the intended receivers. The impact of semantic V2X communications on the scalability of V2X networks, as well as on connected and autonomous driving, will be assessed using a unique and advanced CAM simulator, system-level V2X simulations, and novel semantic KPIs. We estimate that semantic V2X communications can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'software PLATform fOr iNteroperable multiphysics digital mock-up' to be submitted under Horizon 2020.

assistant: **Abstract**

Simulation tools for virtual dynamic mock-ups are more and more adopted by product engineers because they produce essential engineering insights, avoiding significant time and cost investments. Nevertheless, the different modules of the PLM flow do not communicate each other and existing studios suffer from a non-integrated approach. Going cheaper and faster will require new technical offers and business models.  Platon will solve these issues by bringing a disruptive approach at the international level. It will provide an interoperable single environment to applications which will share the same digital mock-up, allowing easier product analysis and optimization. Customers will be able to target 0 costly prototype and to increase engineers’ productivity. Indeed, Platon will enable users to 1) automate many repetitive design and modelling tasks, 2) evaluate the impact of design changes, 3) deploy best practices to non-experts and 4) partner with design & engineering colleagues more effectively. Phase 1 will investigate identified bottlenecks and allow a deeper market analysis. The results will be delivered in updated business plan, leading the solution to the market with clear, measurable, realistic and achievable objectives.  Optis’ strategy is based on a win-win approach with stronger ROI for the entire ecosystem. Optis is structured with international subsidiaries and has delivered more than 7000 licenses worldwide. PLATON already owns its dedicated distribution network and a wide base of clients.  Platon will enable Optis to move from a technology provider position to a solution provider status while other editors proposing complementary approaches will become natural partners through a specific platform agreement.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Regulating privatisation of “war”: the role of the EU in assuring the compliance with international humanitarian law and human rights' to be submitted under Seventh Framework.

assistant: **Abstract**

The goal of the research project is to assess the impact of the extensive use of private military and security companies in situations of armed conflict and to discuss the regulatory framework at national, European and international levels, to assure compliance with international humanitarian law and human rights. Though this is not a new phenomenon, the fear motivating commentators and activists was that private companies operate in a legal vacuum. Although there is growing consensus now in the literature that the situation actually resembles more a complex patchwork of norms, the key question still remains whether and how these existing norms can be effectively applied and whether they need to be supplemented with new norms. Specific objectives are: to promote a better understanding of the phenomenon of the privatisation of war; to clarify the legal status of PMCs/PSCs employees under international humanitarian law; to foster knowledge on the impact of private military activities on the enjoyment of human rights; to analyse international responsibility and accountability of the corporations; to examine the existing regulation at national and EU levels, to explore the ways the EU could regulate PMCs/PSCs. The current proposal seeks to highlight the crucial role of the EU in three respects, which to date have not received much attention in the literature. First, the proposal will seek to offer insights into how the EU can and should develop a unified position on the international regulation of PMCs/PSCs. Second, the work to be undertaken will assess the need for and potential of harmonization of the EU member states’ domestic approaches towards PMCs/PSCs. Lastly, the present proposal will offer advice to policymakers on the development of a regulation scheme at the supr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Coupled fluid-solid numerical modelling for deep-water and far-offshore floating wind turbines using an adaptive finite element method'.

assistant: **Objectives**

The proposed research aims to numerically simulate the impact of far-offshore wind turbines placed in deep waters. Importantly, such turbines offer several advantages over existing wind farms, for example stronger and steadier winds, and reduced visual and noise impact. Therefore, placing wind turbines far offshore will be essential for increasing the share of renewable energy production in the next decade.In current offshore wind farms, the platforms are typically fixed to the seabed and as a result, cost becomes prohibitive in waters deeper than 50 metres. This limitation is a bottleneck for the further exploitation of wind energy in Europe. Far offshore, floating designs minimise the lateral wave loads acting on the turbine and are cheaper than fixed platforms reaching the same depth. In the present study, the hull of the wind turbine consists of a floating steel cylinder attached to the seabed through moorings, while the turbine is modelled as an actuator disc. Numerical tools capable of calculating the complete response of a floating wind turbine with fully coupled hull, moorings and wind turbine are currently at an early stage of development. An efficient strategy to minimise the computational cost is also lacking. To fill this knowledge gap, cutting-edge ocean/fluids and solids computational methods will be employed. Key components are: (a) a numerical wave deep basin that uses unstructured meshing, coupled to (b) a discrete element method for the dynamics of solids with (c) finite element modelling of stresses and (d) mesh adaptivity.The overall deliverable is an open-source code to model the two-way coupling between fluids and floating solids. The proposed tool will be capable of: (1) determining the limits of stability and resistance of the floating system to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Data Portability and Services Incubator' (DAPSI) under Horizon 2020.

assistant: **Objectives**

The General Data Protection Regulation (GDPR) applies since 2018, with the purpose of making significantly easier for citizens to have any data which is stored with one service provider transmitted directly to another provider.DAPSI will foster the advanced research in the Data Portability field through the support to researchers, SMEs and high tech startups from all over Europe.DAPSI proposes a match making process: an intersection between science and business, an opportunity to unite the knowledge and experience of both areas to achieve a common goal around Data Portability. To do so, DAPSI consortium will select the best applications to build complementary teams that will research and apply this advancement to relevant uses cases with market potential in a collaborative way. Up to 58 teams will be selected and only the best ones will progress through three phases of 10 months in an incubation programme where experts in diverse field will provide a successful working methodology, access to top infrastructure, training in business and data related topics, coaching, mentoring, visibility, community building and investment. On top of that, each DAPSI team will receive up to 195k€ equity-free funding, distributing a total amount of 5.6M€ through three open calls.The consortium led by ZABALA and participated by F6S, CAP DIGITAL, IMT, FRAUNHOFER and ENGINEERING will also work to contribute to the progress of the NGI community in the Data Portability domain generating insights and recommendations in the field.


**Keywords:** Data Portability, talent match, Data Transparency, Data Compatibility and Security, Data Analysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dynamic and interactive assessment of national, regional and global vulnerability of coastal zones to climate change and sea-level rise (DINAS-COAST)' (DINAS-COAST).

assistant: **Concept**

A consistent evaluation of coastal impacts and adaptation at national, regional and global scales are required to satisfy current information needs for climate policy. DINAS-COAST brings together the best available science and data to help policy to interpret and evaluate coastal vulnerability to climate change. The project will develop the CD-ROM-based assessment tool DIVA (Dynamic Interactive Vulnerability Assessment), which will allow its users to evaluate the effects of mitigation and adaptation policies on coastal vulnerability, using a range of impact and adaptation indicators. DIVA will contain an extensive library of climate scenarios, derived from a climate system model of intermediate complexity, as well as socio-economic scenarios, a set of impact modules to assess changes in flood risk, wetland losses and socio-economic impacts, and an adaptation assessment module that includes both autonomous and planned adaptation.