RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Functionalised Carbon Nanotube Electrochemical Sensors' (FUNSENS) targeting Seventh Framework.

assistant: **Abstract**

This proposal is for a highly promising young scientist from Spain, Aleix Garcia-Güell, to carry out research and high level training in electrochemical nanoscience, in the renowned Electrochemistry and Interfaces Group at the University of Warwick (UK). The project will greatly enhance the expertise of Garcia-Güell in nanostructured materials, and applications thereof, and take him in significant new directions in the area of single-walled carbon nanotube (SWNT) materials. Specifically, the project will consider novel ideas for a new generation of electrochemical and electrical sensors based on SWNTs and will allow Garcia-Güell to become expert in state-of-the-art nanoscience techniques. The Host Group has recently established that SWNT random networks have very interesting electrochemical properties, including a step change in detection sensitivity, and it is now opportune to build significantly on this work to: (i) develop a detailed understanding of the electrochemistry and conductance of SWNTs at the nanoscale; and (ii) optimise the use of SWNT network and array devices for high sensitivity detection in solution, including bioanalysis. Surface functionalisation will be key part of the programme and Garcia-Güell will bring to bear his expertise, developed in Barcelona and through collaborations in the USA and Germany, on functionalisation strategies using metal nanoparticles and bilayer membranes. The programme is an excellent match of complementary skills of the Fellowship candidate and Host Group and will yield new scientific breakthroughs which will have substantial benefits to European science in this important area. The Fellow will have the opportunity to develop complementary skills essential for career development, through training programmes at the Universit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Fatigue and Abrasion Mechanisms in Fabric Reinforced Rubber Belting' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The central technical objective is to develop an improved understanding of the basic mechanisms of abrasion and crack initiation in fabric reinforced rubber belt. The specific approach is to use new optical surface texture measurements (OSTM) to correlate with filler dispersion, intrinsic flaw size, abrasion and crack initiation. A new abrasion test for rubber abrasion against smooth surfaces will be developed. New optical instrumentation will be developed. A fracture mechanics approach will provide the theoretical basis for finite element analysis of crack and abrasion formation with a crack modelling step size of 0.001 to 0.01mm. Full scale belt fatigue tests will be performed for two types of industrial belt made under factory conditions, to verify the approach. New flouro elastomer compounds will be developed for ten times improved fatigue resistance for colour photocopier machines. The industrial objectives are closely linked to the technical objectives. The first industrial objective is to develop a fabric reinforced rubber belt (the fuser belt) for image transfer in new high volume colour photocopier machines to have between 4 and 10 times better resistance to abrasion and fatigue (from 300,000 to 5,000,000 copies before replacement). The second industrial objective is to develop an optical instrument for the non destructive evaluation of the fatigue resistance of vulcanised rubber belts. The third industrial objective is to develop a compound development methodology for the fatigue resistance of conveyor belts for mining and people transport applications. Advanced finite element modelling techniques will be used to assess the fatigue life of belt design as a design tool. The proposal describes the industrial problems and technical objectives, the current state o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Developing new antibiotic peptides targeting ESKAPE bacterial trans- translation' (TRANSPEPTID).

assistant: **Concept**

Antimicrobial resistance (AMR) poses a major threat to human health around the world. The AMR crisis has emerged as one of the leading public health threats of the 21st century. This global crisis is due to the fact that bacteria share and increasingly develop new resistance mechanisms as a consequence of the misuse of antibiotics, as well as a lack of new drug development. To combat this crisis, we need new classes of antibiotics, and most importantly, against new targets. It is therefore crucial to identify new molecular processes that can be targeted. Ideally, these should be: i) conserved among all pathogenic ESKAPE bacteria; ii) indispensable to bacterial survival or at least its fitness; iii) sufficiently variable that different species can be distinguished from each other; iv) absent in eukaryotes; v) not targeted by current antibiotics; vi) unrelated to existing AMR mechanisms; and finally, vii) reproducible in non- hazardous in vitro experiments. In this quest, trans-translation appears to be a perfect candidate. Development of new antibiotics that target trans-translation from multidrug resistant ESKAPE pathogens will be addressed in this project (TRANSPEPTID). We will use engineer antimicrobial peptides based on the C- terminal tails of SmpB proteins from ESPAKE pathogens with the propose to compete with endogenous SmpB, and in turn to inhibit trans-translation. The project is organized in three main objectives that will constitute three major breakthroughs in the field: (OB1) Optimization and characterization of designed peptides in ESKAPE pathogens, (OB2) Biophysical analysis of selected peptides in target ESKAPE pathogens, and (OB3) Determination of the high- resolution structures of the complexes between the peptides and their molecular targets by cryo-EM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Beyond Biopolymers: Protein-Sized Aromatic Amide Functional Foldamers'.

assistant: **Objectives**

Nature has evolved ultimate chemical functions based on controlling and altering conformation of its molecular machinery. Prominent examples include enzyme catalysis and information storage/duplication in nucleic acids. These achievements are based on large and complex yet remarkably defined structures obtained through folding of polymeric chains and a subtle interplay of non-covalent forces. Nature uses a limited set of building blocks – e.g. twenty amino-acids and four nucleobases – with specific abilities to impart well-defined folds. In the last decade, chemists have discovered foldamers: non-natural oligomers and polymers also prone to adopt folded structures. The emergence of foldamers has far reaching implications. A new major long term prospect is open to chemistry: the de novo synthesis of artificial objects resembling biopolymers in terms of their size, complexity, and efficiency at achieving defined functions, yet having chemical structures beyond the reach of biopolymers amenable to new properties and functions. The PI of this project has shown internationally recognized leadership in the development of a class of foldamers, aromatic oligoamides, whose features arguably make them the most suitable candidates to systematically explore what folded structures beyond biopolymers give access to. This project aims at developing methods to allow the routine fabrication of 20-40 units long aromatic oligoamide foldamers (6-15 kDa) designed to fold into artificial molecular containers having engineerable cavities and surfaces for molecular recognition of organic substrates, in particular large peptides and saccharides, polymers, and proteins. The methodology rests on modelling based design, multistep organic synthesis of heterocyclic monomers and their assembly into l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Defining of human adaptive immune gene diversity and its impact on disease' to be submitted under Horizon 2020.

assistant: **Abstract**

Why do vaccines protect some people but not all? Why can some people develop potent neutralizing antibodies to infections, while others cannot? Why do some people develop immune-associated diseases such as allergy, rheumatoid arthritis, multiple sclerosis and diabetes over their lifetimes, when the body has evolved to tolerate self? The answer lies in the adaptive immune system. B and T lymphocytes of the adaptive system express highly polymorphic receptors that allow for the recognition of large numbers of antigens. Our research is now uncovering an enormous heterogeneity in the germline genes that encode our B and T cell receptors. This fact has not been well appreciated because of the high complexity of the genomic regions that encode these receptors, with the presence of large insertions and deletions, a high degree of repetitiveness and gene copy number variations, which cannot be adequately met with conventional whole genome sequencing approaches. We have developed a state-of-the-art approach we call IgDiscover, which comprises novel molecular library preparation approaches, next generation immune repertoire sequencing, computational analysis and a software that allows rapid construction of personalized antibody gene databases encompassing the hundreds of germline gene segments that rearrange to make up each individual’s naïve B cell repertoire. Thus, IgDiscover offers new possibilities to define human genetic diversity in these loci. This proposal also describes our development of ImmuneDiscover, a high throughput approach enabling personalized immune-profiling of very large numbers of individuals (>1000), encompassing not only Ig genes but also T cell receptor genes and the genes encoding the human major histocompatibility complexes. Here, we will use IgDiscover
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ambient-Intelligent Interactive Monitoring System for Energy Use Optimisation in Manufacturing SMEs' under Seventh Framework.

assistant: **Concept**

The main business aim is to produce a leap forward in energy efficiency and cost reduction in manufacturing SMEs.<br/>The AmI-MoSES project will develop an (ambient) intelligent monitoring system for energy consumption, dedicated to manufacturing SMEs, to provide comprehensive information about the energy use, and knowledge-based support for improvements in energy efficiency. Existing energy consumption data will be complemented by different information from AmI systems (e.g. AmI systems for interactions between human operators and machines/processes etc.) and process related measurements (e.g. specific manufacturing line temperatures) and fed to the SOA based platform. The platform will allow to build different SW services, using the measured and processed data, such as On-line diagnostics of energy related problems in an SME, Continuous improvement of energy consumption etc. The services will, among other functionalities, interactively provide suggestions of the appropriate actions for problem elimination and energy efficiency increase. <br/>The decision making support for the energy efficiency increase will be also environmentally based, meaning that the problem elimination suggestions will always take care about the environmental performance from the manufacturing SME sectors, reducing the need for natural energy sources. <br/>The consortium SMEs will provide industrial testing environments, some of the major technical inputs including the energy measurement equipment, energy consumption monitoring, energy auditing, and energy saving expertise.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Digital Generation of High Resolution Objects' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This proposal presents a development project for a micro scale Additive Manufacturing (AM) system. AM systems can take computer designed or scanned files describing 3-dimensional shapes and make physical (often plastic or metallic ) objects. Typical AM systems make objects that have feature sizes suitable for human interaction; the low end being a fraction of a millimeter. The proposal presents research into systems that are capable to smaller features down to few micrometer sizes. The proposal describes inexpensive technology that is capable to few micrometer features. Part of the research program is also background experiments that verify the material capability. The plan is to study many applications of micro scale AM technology, including micro fluid diagnostics (lab-on-the-chip) and medical applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Roots of Infection', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Plant roots and soil microbes have been associated since the emergence of plants on land. Nevertheless the mechanisms that have coevolved to control these commensal and mutualistic associations are currently unknown. RINFEC will identify both plant and bacterial genes involved in root colonization by commensal and mutualistic bacteria with an approach that would be transformative in the field. The ambitious challenge is to identify and functionally characterize the central genes controlling root cells competence for infection. RINFEC´s central hypothesis is that key components of ancient pathways for bacterial colonization of the root surface (rhizosphere) and root interior (endosphere) were adapted during evolution of mechanism(s) controlling colonization of legume roots by symbiotic rhizobia. RINFEC will uncover the genetics and biochemistry of these shared mechanisms by characterizing a novel, unexplored intercellular infection mode observed for certain rhizobia that act as endophytes in non-legume plants and are able to infect the model legume Lotus japonicus. The unique biological feature exploited in RINFEC is the capacity of Lotus to support either intercellular entry (conserved mode) or legume specific infection thread entry, dependent on the rhizobia encountered. This allows comparative investigations of these two infection modes in simple binary interactions with the same host. Given the exceptional ability of different rhizobia for intercellular endophytic colonization of non-legume roots this provides an unprecedented platform to identify mechanisms by which plants selectively enable a subset of bacteria to infect roots. RINFEC will build on my considerable expertise with Lotus and pioneers novel plant and bacterial genetic methods, cell-layer transcriptomic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Brain Connectivity for Executive Control over Action in Ageing' (ConnectExAct-Age), addressing dissemination and exploitation.

assistant: **Impact**

One hallmark of ageing is a motor functioning decline that represents a crucial impediment for healthy and active living. This multidisciplinary project combines detailed motor and neuropsychological assessments with multimodal neuroimaging techniques in an exceptionally large sample to pave the way for cognitive training interventions to improve motor functions in older adults.Its focus is on executive functions, i.e., high-level mental processes that control goal-directed, coordinated motor behaviour. These functions are likewise affected by ageing, but the contribution of executive decline to age-related motor impairment has not yet been unravelled. Executive functions are not a unitary capacity but span different facets. My project will reveal which aspects of executive functions are most relevant for movement control and its decline in older adults and thus constitute promising intervention targets. Structural and functional magnetic resonance imaging will reveal the neural basis of the links between executive and motor functions from a network perspective—an approach at the cutting edge of current neuroscience research. Profound re-organization of brain networks occurs during ageing, with aberrant coupling between usually distinct brain areas. This work will unravel how functional and structural network alterations are linked to motor and executive performance, allowing for a better understanding of age-related performance declines in both domains.The fellowship constitutes a perfect opportunity to develop my research and transferable skills. New skills as well as collaborations with my host group’s network will strengthen my profile as a researcher and place me in a strong position when competing for a permanent academic post. Combining my neuropsychological expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of external peer review techniques', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

To exchange experience in health services accreditation, including external peer review systems, by identifying existing organisations actively pursuing accreditation systems, by cataloguing achievements, and by networking. To establish mechanisms for collection and dissemination of concepts, implementation and training, and to support integration of external peer review systems with internal quality improvement.Supported by CASPE Research in London (and its subsidiary Hospital Accreditation Programme based in Bristol), a centre will be established and staffed to co-ordinate information on current and proposed development, including to: - Identify existing organisations by literature review and direct contact - Catalogue achievements as surveyed by partners through structured questionnaire and visits to identified organisations - List and obtain publications on European systems, including grey literature - Establish network including bulletin board accessible by modem to include contact details of organisations, bibliography and future eventsMechanisms for collection and dissemination will be established including: - Baseline seminar: two-day meeting of participating states in London to discuss survey report and identify-priorities for joint action - Topic seminars: two-day seminars on identified priority concerns, each to be researched, prepared, organised, hosted and written up by one principal partner. The agenda will be developed from the baseline seminar but is likely to include themes such as: Position and operation of a accreditation programmes. Specialty applications of accreditation systems. Structure and development of accreditation standards. Statistical comparisons in accreditation -Open conference: two-day meeting to report on progress, recruit new particip