RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Air pollution and health: a european approach elaborating methods and results to support public health policy', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Under FP4, the APHEA2 project, investigating the short-term effects of air pollution on health (end date 31-1-2001) produced results and developed methods. This proposal aims to advance the methods developed by APHEA2 and other researchers and to produce further results directly usable for health impact assessment (HIA) and public health policy. The project is structured in 3 six-month research periods followed by 3 Workshops, which will discuss and review the results. The topics will cover: 1. Dose-response curves over the current pollutant ranges and their combination (meta-analysis); 2. Lag structures and mortality admissions displacement (harvesting); 3. Climate, weather, air pollution and health; 4. Dissemination of methods. The databases to be used here have already been compiled under APHEA2. Pollutants considered: PM, NO2, SO2, O3 and CO and health outcomes: total and cause specific mortality and respiratory and cardiac admissions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Open Consortium for Decentralized Medical Artificial Intelligence' under Horizon Europe.

assistant: **Concept**

ArtifArtificial Intelligence (AI) will revolutionize healthcare as its diagnostic performance approaches that of clinical experts. In particular, in cancer screening, AI helps patients to make better-informed decisions and reduce medical error. However, this requires large datasets whose collection faces severe practical, ethical and legal obstacles. These obstacles can be overcome with swarm learning (SL) where partners jointly train AI models without sharing any data. Yet, access to SL technology is seriously limited because no studies have implemented SL in a true multinational setup, no practically usable implementation of SL is available, researchers & healthcare providers have no experience with setting up SL networks and policymakers are currently unaware of the broader implications of SL. ODELIA will address & solve these issues: ODELIA will build the first open-source software framework for SL, providing an assembly line for the streamlined development of AI solutions. To serve as a blueprint for future SL-based AI systems, ODELIA partners collaborate as a swarm to develop the first clinically useful AI algorithm for the detection of breast cancer in magnetic resonance imaging (MRI). The size of ODELIA's distributed database will exceed all previous studies and ODELIA's AI models will reach expert-level performance for breast cancer screening. Thereby, ODELIA will not only deliver a useful medical application, but prove the clinical benefit of SL in terms of accelerated development, increased performance and robust generalizability to ultimately save thousands of lives of European patients. ODELIA's success will push partners to serve as nuclei for the exponential growth of the SL network and extend SL to a multitude of medical applications. Thus, patients, hea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SUPPORT ACTION for a European and Latin American Strategic cooperation on Networked Media RandD' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

SALA+ is a Support Action (SA) intended to foster International Cooperation in the area of Networked Electronic Media (NEM) between Europe and Latin America. The global aim of the project is to prepare for future concrete partnerships between Europe and Latin American countries.<br/>SALA+ will provide support to the implementation of the FP7 ICT Work Programme. In this context, the SALA+ project will encourage entities from Europe and Latin America to cooperate in the Networked Media field through collaborative R&D projects.<br/>SALA+ will identify specific areas for Scientific & Technological cooperation within the Networked Electronic Media field. One of the most relevant expected results from SALA+ will be the establishment of robust relationships between European and Latin American entities (industrial sector, universities, technological centres, associations, etc.) aiming to foster the launch of collaborative R&D projects in the context of the forthcoming  FP7 ICT Work Programme 2009-2010 and beyond. <br/>In addition, the SALA+ project will:<br/>1. Identify the Latin American R&D programmes and agencies responsible for research activities in the Networked Media sector and propose new R&D themes suitable for enhanced scientific cooperation between EU and Latin America. <br/>2. Produce one specific Strategic Research Agenda (SRA) per country for the following countries: Argentina, Chile, Colombia, Costa Rica, Guatemala and Uruguay. <br/>3. Produce one harmonized EU-Latin America SRA, in alignment with the NEM Technology Platform SRA and other European national R&D programmes in terms of priorities, objectives, expected output, impact, etc. This harmonization is intended to facilitate future cooperation between European and Latin American partners.<br/>4. Organisation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '3D organization of yeast MAP-kinase modules' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Eukaryotic cells contain myriad signaling pathways used to transmit information from the plasma membrane to the nucleus. Given the large number of pathways in a cell, how is it that a given stimulus leads to a precise response?  This problem is particularly acute in kinase pathways, such as mitogen-activated protein kinase (MAPK) cascades, which often share common protein components.  Over the last decade, however, a paradigm that has emerged is that signaling pathway specificity can be mediated, in part, by scaffolding proteins that bind pathway members and restrict them to act only on one another. In yeast, as well as in mammals, several scaffold proteins for MAP-kinase cascades have been identified.  These scaffolds allow one or more common kinases to function in distinct signaling pathways without improper cross-talk.  However, very little is known about the mechanism by which these scaffold molecules physically control transmission of signaling information. We therefore plan to determine the three-dimensional structures of MAP-kinase modules of the yeast mating and high osmolarity response pathways, which are organized by two non-related scaffold proteins: Ste5 and Pbs2. The components (four kinases and two scaffold proteins) will be expressed as recombinant proteins and the complex reconstituted in vitro. We will use a multifaceted approach with the following specific aims: (1) to determine the structure of the reconstituted Ste5 and Pbs2 scaffolded complex by X-ray crystallography or electron cryomicroscopy and (2) to identify well-ordered fragments of the scaffolds that interact with individual member kinases to determine the structure of informative sub-complexes by X-ray crystallography.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'System wide information management-supported by innovative technologies', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

SWIM will be the main technical enabler for the implementation of the European ATM Network, foreseen in the Single European Sky Legislation. The SWIM-SUIT project aims to demonstrate the feasibility of initial System Wide Information Management functionality for the Air Transport System.Starting from the OSEDs, provided by C-ATM Phase 1, the SWIM-SUIT Project will firstly specify the Requirements of ATM Information Management, by means of the expertise of the wide Users participation to the Project as ANSPs, Airlines and Airports. Secondly a tailoring of the requirements will be done to define the context of the SWIM-SUIT prototype. Then a SWIM-SUIT Prototype will be specified, designed, developed and tested by means of several existing Users Applications as ACC/APP Centers, Airport CDM, Airlines Operating Center, CFMU, Flight Simulator which will be connected to the test-bed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Paraneoplastic Neurological Syndromes (PNS) strengthening the European network' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Paraneoplastic neurological syndromes (PNS) are severe disorders of the nervous system that arise as remote effects of neoplasia. Diagnosis of PNS is currently aided by detection, in patients' serum and cerebrospinal fluid, of specific autoantibodies that recognize antigens shared by the tumour and nervous system cells. In most cases, correct diagnosis of PNS permits early detection of the tumour, before it can metastasize. The rarity of PNS prompt the need for multicentric studies to collect sufficient numbers of patients on which to base specific studies. With the support of an EC grant (QLG1-CT-2002-01756), a Network of reference centres located in over 10 European nations was established for these pathologies (see www.pnseuronet.org). During the first 2 years of the scheduled 3 years' activity, a DATABASE has been developed and validated for the standardized collection of information on PNS patients dating from 2000, and a central bank set up to store biological material.This Network has defined and published guidelines for the first time on PNS diagnosis, which will facilitate clinical diagnosis of the diseases and the collection of uniform groups of patients for specific studies. Over 500 cases have now been collected in the database which, considering the rarity of the diseases, is a very significant number, unmatched in the international literature. The aim of the project is to a) be able to continue, for 3 more years, to input patients in the database, making the necessary quality controls on incoming data, and to maintain centralized storage of biological material; b) diffuse information yielded by the database; identify and design specific studies on uniform groups of these diseases; and c) clinically characterize new PNS pathologies emerging from analysis of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'INTER-REGULATION OF CIRCADIAN AND AUTOPHAGIC PROCESSES IN STEM CELLS: IMPACT ON TISSUE REGENERATION AND AGING' in the context of a Horizon 2020 call.

assistant: **Objectives**

Regeneration of skeletal muscle relies on its stem cells, also called satellite cells (SCs). These cells remain quiescent throughout their life, and only activate in response to injury to form new muscle fibers. The regenerative capacity of these cells declines with aging. In the past years, Pura Muñoz Cánoves’ lab showed that, with aging, quiescent SCs 1) lose basal autophagy and 2) reprogram their circadian transcriptome (including the autophagic transcriptome). The molecular bases of these processes, their potential interrelation and the consequences of their failure with aging, are unknown. Our integrating hypothesis is that active autophagy and circadian regulation are interconnected and required to preserve stem cell regenerative fitness throughout life. We aim to answer the following questions: Which is the relative contribution of the stem-cell-intrinsic versus the organismal clock to muscle regeneration during aging? Are circadian and autophagy processes interconnected? This is, does circadian clock disruption alter autophagy in SCs? Conversely, does autophagy disruption affect their circadian regulation? If so, does autophagy re-induction by nutritional regimes restore circadian and regenerative functions in aged SCs? Mice genetically-modified for depletion of 1) selected circadian clocks or 2) autophagy will allow us to assess the relative contribution and interrelation of autophagic and circadian machineries to muscle regeneration during aging. We expect that completion of this project will provide new fundamental knowledge on stem cell biology, regeneration and aging, which will open opportunities for stem cell rejuvenation.


**Keywords:** circadian clock, stem cells, muscle regeneration, autophagy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Best e-Europe Practices' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The BEEP project is concerned with analysing and exploiting socio-economic best practice in four main domains of the e-Europe initiative:employment and skills,digital SME,social inclusion and regional cohesion,and in the important cross themes between them.Extant data sources from both Commission-supported and other high quality initiatives will be used, most of which are not widely used and few are interlinked, though there is a great need for understanding and exploiting available knowledge at a European level.BEEP will also update this best practice knowledge in line with on-going developments, especially by closely supporting RTD projects and taking up their results. Data will be analysed qualitatively and quantitatively to draw out socio-economic best practice and provide benchmarking standards.Results will be widely disseminated in the programme and produce three fully developed services:socio-economic best practice,benchmarking,5Land linked knowledge (data) bases.These services will comprise a comprehensive set of tools available interactively on a user-friendly web-site which organisations and individuals will be able to easily exploit.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Uncertainty Enabled Model Web' to be submitted under Seventh Framework.

assistant: **Abstract**

UncertWeb will create the Uncertainty enabled Model Web by allowing interoperability between data and models with quantified uncertainty, building on existing open, international standards. In particular UncertWeb will develop encoding standards, service interface profiles, discovery and chaining mechanisms and open source implementations, and generic tools to realize a 'model Web' that takes uncertainty in data and models fully into account.<br/>The developments in UncertWeb will be validated by scenarios from four environmental application domains: biodiversity and habitat change, land use and policy modelling, local air quality forecasting, and individual activity in the environment. In each application domain prototype service chains will be built using UncertWeb technology. To further evaluate the discovery and chaining mechanisms UncertWeb will integrate the air quality and activity modelling to produce novel service chains that quantify individual exposure and the effects of individual's activity choices on emissions with quantified uncertainty.<br/>The project will deliver encoding standards, interface profiles and open source software implementations to allow continued development of the Uncertainty enabled model Web beyond the funding.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ultrasensitive probing of wet adhesion and charge dynamics in soft materials', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Soft wet adhesion is a physical phenomenon exploited by organisms that live in wet environments to allow them to adhere to surfaces despite charge barriers that typically hinder adhesion. The physics underpinning soft wet adhesion has been studied for over a century. The interplay between charge and adhesion dynamics in soft adhesion is strongly complicated by non-linear and time-dependent effects for different compression rates and environmental conditions and remains poorly understood due to the lack of simultaneous charge and force-based experiments on pairwise interactions in dynamic conditions. Understanding charge-adhesion interplay is important for novel biomedical and engineering applications. Here, I will develop an Electro-Adhesion Microscope to probe real-time interactions between soft wet adhesion and charge at piconewton and femtocoulomb resolutions. Using a hydrogel soft probe to mimic tissue and conductive hydrogel as soft adhesive I will determine how charges vary with compression rates and stiffnesses for anionic and cationic adhesives and soft probe, and how these charge changes influence adhesion in water and complex fluids. By adopting soft probe to wet probe, I will also explore these interactions in the presence of a thin liquid film in air. Together this will resolve several major questions on charge-adhesion interplay, with the grand goal of discovering new insights into how and why charges influence soft wet adhesion dynamics. These experiments will pave the way for new research in soft matter adhesion dynamics, providing critical data on force, charge, interface deformations, and fluid dynamics for theorists and engineers in biomedical applications. The outcomes of this project will enable the creation applications such as regenerative medicine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Acoustic and thermal instrumentation, tests and modelling of engine surface coolers in representative aerodynamic conditions'.

assistant: **Concept**

The present proposal addresses the acoustic and thermal instrumentation, tests and modelling of engine surface coolers in representative aerodynamic conditions. In addition to aerodynamic tests already performed on surface coolers in a regional funded project, complementary tests have to be conducted to characterize these equipments from a thermal and acoustic point of view. The concerned Air Cooled Oil Cooler thermal characterization will be performed in a high speed wind tunnel, especially adapted in order to host this device and to retrieve take-off engine-like conditions. The main expected results are the quantification of heat extraction and the surface temperature maps of the heat exchanger. The contribution to the acoustic investigation is principally focused a detailed analysis of the measurements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Re-exposure Effect in Bilinguals under Language Development (REBUILD)-The Acquisition of Heritage Language in Returnee Children and Mutual Effects of Experience and Cognition' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Many (immigrant) children are heritage speakers (HSs; bilinguals who acquire a minority language at home, different from the majority societal language in which they are growing up). Ultimate attainment of the heritage language (HL) varies considerably amongst individual HSsmuch more profoundly that what can be noted in monolingual counterpartsdespite being naturalistic natives from birth. Understanding what factors explain/predict such differences in HS outcomes is a necessary first step in assessing and, ultimately, being able to meet the educational/interventional needs for bilingual HL development. Re-exposure Effect in Bilinguals Under Language Development (REBUILD) propose a novel approach that combines offline and online methods and focuses on a severely understudied, yet crucially important group of heritage speaker bilinguals, namely returnees.  Returnees are children of immigrant families who spend a significant portion of their formative developmental years (school age) in a foreign majority language context, a typical HL scenario, yet return to their native HL environment, often as older children or teenagers. This research is important for the global reality in which HL bilingualism proliferates and HL returnees increase year-on-year. Examining the development of returnees native HL from the point of re-exposure to the native environment opens up new directions. While research shows that HL bilingualism (HLB) grammatical outcomes vary significantly, findings are largely limited to contexts in which children grow up and stay in an environment where the native HL is a minority language. Environment transitionsas in the case of returneesopen an exciting opportunity to tease apart internal (grammatical structure, non-linguistic cognitive abilities) and external