RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Coordination action in support of the implementation of the Joint Programming Initiative on 'Healthy and Productive Seas and Oceans'' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

CSA Oceans 2 is a 36 month project with the general aim to facilitate and support the implementation of the Strategic Research and Innovation Agenda (SRIA) of JPI Oceans. CSA Oceans 2 will build further on the outcomes of the FP7 CSA Oceans project.To achieve the objective above the project has been organised in five work packages:- WP1 will allow to link closely the project with the JPI Oceans structures namely the Management Board, the Executive Committee, Strategic Advisory Board and the JPI Oceans Secretariat and involve them in the CSA activities- WP2 will deal with the implementation of joint transnational activities and will facilitate the organisation of the activities, it will guide the member countries in identifying and selecting the best fit for purpose (new) tools and provide a framework for evaluating, assessing and monitoring of the actions- WP3 aims at maintaining and further developing the relationships between JPI Oceans with different relevant actors (research funding organisations (RFOs), Ministries, research performing organisations (RPOs), industry and partners outside of the EU) in the field of marine and maritime sciences in supporting the implementation of JPI Oceans agreed actions- WP4 will support the implementation of the SRIA through thematic foresight mechanisms and will design a process for JPI Oceans to update its SRIA, Implementation Plan and Operational plan.- WP5 will deliver the necessary tools for the information management as well as outreach and dissemination of CSA Oceans 2 project and JPI Oceans' activities.The CSA Oceans 2 project will be performed by a consortium of a mix of funding, coordinating and research performing organisations. All are members of the JPI Oceans Management Board or have a close connection to their nationa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Fermentation processes for functional foods from RAPeseed, Sunflower and Other EU matrices Devoted to Young animals.Zero-miles model boosting safety and competitiveness of livestock sector' (RAPSODY).

assistant: **Concept**

In the next future, the global population growth will increase the demand for animal derived food.The livestock sector development is a compelling societal challenges to ensure animal welfare, consumers health and the productivity and environmental sustainability of the livestock system.To replace imported soybean and fishmeal as protein sources in the young animal dietary, RAPSODY aims at developing innovative functional foods transforming by-products derived from European agriculture (rapeseed, sunflower and other matrices) and alternative feed source (seaweeds) through the application of bio-technology based fermentation processes aimed at: 1) increasing digestibility, 2) enhancing/balancing the amino acidic profile of the starting matrix.Compared to Soy Protein Concentrate and fishmeal, the benefits associated with the new products are:- Safer, cost-effective natural products for animal feeding, reducing harmful substances and synthetic additives in the final food; - Minimize imports, strengthening European self-sufficiency for the livestock sectorRAPSODY will also provide an innovative business model for the production and commercialization of the final functional foods according to a “zero-miles” system, by localizing small productive plants near raw materials suppliers and final users. The model will boost the competitiveness of the livestock sector: the superior quality in terms of nutritional value and final food safety, together with competitive prices with respect to SPC and fishmeal, will allow the new products to acquire the 35% of the swine market share within 5 years, generating an annual turnover of 150 million euros/yThe feasibility study will allow- The definition of the preliminary layout for the demonstration plant- the development of strategic partn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'IMPROVING HEMATOPOIETIC STEM CELL- BASED GENE THERAPY OUTCOME BY MODULATING CXCR4 EXPRESSION'.

assistant: **Concept**

β-thalassemias and sickle cell disease (SCD) are caused by mutations in the β-globin gene (HBB) that result in the defective synthesis (β-thalassemias) or the production of an abnormal variant (SCD) of hemoglobin. Currently, the only curative option is allogeneic transplantation of hematopoietic stem cells (HSCs), but it is severely limited by conditioning toxicity and the restricted availability of compatible donors. Alternative strategies, based on lentiviral vector (LV)-mediated introduction of a functional copy of the HBB gene followed by autologous transplantation, are currently explored. Despite the fact that clinical data are promising, achieving a broad therapeutic benefit still remains a major hurdle because of inefficient gene correction and competition of the endogenous affected HSCs.In this proposal, I intend to confer an in vivo competitive advantage to transduced HSCs in terms of homing and engraftment efficiencies by modulating the expression levels of the chemokine receptor CXCR4 through two different approaches. On one hand, as increased CXCR4 levels enhance bone marrow (BM) homing, I will develop an innovative LV-based strategy to transiently deliver CXCR4 into HSCs to improve their migration to the BM. On the other hand, as CXCR4 haploinsufficiency enhances proliferation of homed HSCs, I will develop LVs down-regulating CXCR4 expression to endow corrected HSCs with an increased BM repopulating capacity. Thanks to these strategies, corrected HSCs will be able to out-compete non-corrected as well as endogenous affected HSCs, thus attaining therapeutic levels of engraftment even with a reduced number of corrected HSCs. In addition, this will contribute to use a milder conditioning regimen, normally required to eliminate endogenous affected HSCs, and thus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Large-scale EXecution for Industry & Society'.

assistant: **Concept**

The increasing quantities of data generated by modern industrial and business processes pose enormous challenges for organizations seeking to glean knowledge and understanding from the data. Combinations of HPC, Cloud and Big Data technologies are key to meeting the increasingly diverse needs of large and small organizations alike. Critically, access to powerful compute platforms for SMEs - which has been difficult due to both technical and financial reasons - may now be possible. LEXIS (Large-scale EXecution for Industry & Society) project will build an advanced engineering platform at the confluence of HPC, Cloud and Big Data which will leverage large-scale geographically-distributed resources from existing HPC infrastructure, employ Big Data analytics solutions and augment them with Cloud services. Driven by the requirements of the pilots, the LEXIS platform will build on best of breed data management solutions (EUDAT) and advanced, distributed orchestration solutions (TOSCA), augmenting them with new, efficient hardware capabilities in the form of Data Nodes and federation, usage monitoring and accounting/billing supports to realize an innovative solution. The consortium will develop a demonstrator with a significant Open Source dimension including validation, test and documentation. It will be validated in the pilots - in the industrial and scientific sectors (Aeronautics, Earthquake and Tsunami, Weather and Climate) – where significant improvements in KPIs including job execution time and solution accuracy are anticipated. LEXIS will promote the solution to the HPC, Cloud and Big Data sectors maximizing impact through targeted and qualified communications. LEXIS brings together a consortium with the skills and experience to deliver a complex multi-faceted project,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The BIOTELEKINESY home-care service : a communication platform for the tele-monitoring and the tele-management of the elderly to detect locomotion disabilities and prevent fall' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The context of our ageing population and the expenses explosion linked up with healthcare request for the elderly, innovative solutions strongly related to prevention, to an improvment of the quality of life and to an upholding of an independent life as long as possible. Therefore, the core of the BIOTELEKINESY project is to provide an innovative ICT based interface with a holistic approach to detect and prevent as earlier as possible in the daily environement of the elderly person, motion disabilities and as a consequence fall risks. It will consist of a monitoring and assessing devices, to gather biomechanics data that can be indicators of locomotion impairments, related to a secure interopearbility system that connect the elderly, the healthcare providers and the family to early implement appropriate rehabilitation therapies. The method will deal with three main goals such as : firstly, the creation of a kinematic database through a clinical gait analysis to highlight and identify the biomechanics predictors of locomotion deficits ; secondly, the implementation of a real time motion recognition system for an accurate classification of elderly actions in different levels of locomotion deficits and thus the development of a treshold algorythm for the elderly activity classification ; thirdly, the development of a secure and friendly-user interface. This home-care service promise to improve healthcare management procedures with benefits both for seniors, healthcare providers and healthcare systems. In particular, it will enable to prevent fall in an effective manner in term of quality and cost by an accurate and personalized follow-up of the seniors motion capacity; a more personal and efficient interaction between them and the medical staff to implement in real time re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A comparative study of operating hours, working time and employment in france, germany, the netherlands, portugal, spain and the united kingdom' (EUCOWE), addressing dissemination and exploitation.

assistant: **Impact**

The proposal is for the collection of new comparative and representative survey data on the relationship between operating hours and working time management and their consequences for employment in France, Germany, the Netherlands, Portugal, Spain and the United Kingdom. Operating hours and working time management are crucial for economic competitiveness and organisational performance and closely linked to job security and creation and thus social welfare as well, which may affect women and men differently.However salient these issues are today in the European Union and with steeper competition in a global economy, there is a great lack of information. A standardized enterprise survey would collect data for all sectors of the economy and all firm sizes and be designed to serve as a prototype survey in order to have the option of building the knowledge base to include all EU countries in future research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Microwave & infra red industrial applications for diamond'.

assistant: **Objectives**

The main aim of this project is to demonstrate the potential of diamond components to improve the performance and reduce the cost of microwave and IR optical systems. The components addressed are insulators and windows for microwave travelling wave tubes, gyrotrons and klystrons, and windows for high power CO2 lasers. Diamond will be used to replace the present components fabricated from BeO, sapphire, ZnSe etc. The very high thermal conductivity and low thermal expansion coefficient of diamond will allow the systems to be run at higher powers with simpler cooling arrangements. The diamond deposition process will be optimised to give low microwave absorption, low permittivity, low IR absorption and scatter and high thermal conductivity material. This will be achieved by relating detailed measurements of the microwave, IR and thermal properties with the growth conditions and setting-up a feed back loop. Plasma modelling and diagnostics will be used to support the optimisation, and assist with the scaling-up of the deposition process to produce 100mm diameter self-supporting wafers. The electrical and mechanical properties of the diamond will be measured to allow demonstrator components to be designed. Detailed material characterisation of the diamond will be carried out to relate the measured properties to structural features and thus to the growth parameters. Techniques for cutting and polishing diamond will be developed to achieve the dimensions and surface finishes required for the demonstrator components. Brazing and other joining processes will investigated for attaching the diamond to metal mounts. Microwave tube and CO2 laser demonstrator components will be designed for use within demonstrations at two end user establishments. In one, the performance of a large di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Interrogating macromolecular assemblies by using fragment-based small molecule approaches: The multiprotein von Hippel Lindau-E3 ubiquitin ligase complex' (2007-2013).

assistant: **Innovation**

Most proteins exert their biological function by interacting with other proteins in complex macromolecular assemblies. Modulating protein:protein interactions (PPIs) using small drug-like molecules has the potential to unlock new horizons for chemical biology and developing novel therapeutics. However, this task has proven difficult because of the diverse, complex and dynamic nature of PPI interfaces. This project aims at investigating the plasticity and druggability of PPI interfaces within multi-protein assemblies by an innovative approach combining fragment-based chemical tools, biophysical and structural methods, using the von Hippel Lindau (pVHL)-Cullin Ring type E3 ubiquitin ligase (CRL) complex as a model system. The pVHL-CRL is responsible for the recognition, poly-ubiquitylation and subsequent degradation of HIF-1α, a key regulator of cellular oxygen sensing. This interaction is impaired during the hypoxic proliferation of tumours and as a result of pVHL mutations in the VHL disease, a human syndrome predisposing to cancer. By characterizing the binding of fragments to wild-type and disease mutants of this multi-subunit complex, this project will provide novel insights on the important features for small molecule targeting to PPI interfaces and on how to modulate PPIs not only directly by targeting the interaction hot spots, but also indirectly e.g. through binding to distant allosteric sites. Such knowledge will also be harnessed towards developing novel drug like small molecules, by applying NMR techniques for the detection of fragment binding to adjacent sites and developing dynamic combinatorial X-ray crystallography to in situ linking of these fragments. By improving our understanding of how to discover small molecule enhancers/stabilizers as well as inhib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'High performance computational environment for vibro-acoustic optimization' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The project aims to bring together major computer-aided engineering suppliers and automotive manufacturers to develop a high-performance and high-productivity framework for noise and vibration analysis, specifically for vibro-acoustic optimisation.In current practice, several hours of computation on a multi-processor system are needed to analyse a single configuration only. Stricter environmental regulations for external noise and increased customer expectations for both noise and vibration levels are forcing leading automotive companies to improve not only their design methodologies but also the supporting computational environments. The full benefit of vibro-acoustic optimisation tools will only be realised if their performance is dramatically increased. This is essential if the product refinement and optimisation phase is to match the demands imposed on development and engineering by competition and stringent time-to-market targets. This project further addresses issues extremely important for improving the productivity of the overall vibro-acoustic optimisation process by tackling the major issues of data flow and meshing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European unified approach for accessible lifelong learning' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The Lifelong Learning paradigm recognises that, in a knowledge based economy, education and work are integrated throughout people's lives. All citizens need ongoing access to learning to enable them to work. Technology is playing an increasing role in mediating this learning. However, if this technology is inappropriate and introduced with insufficient support, disabled people will face even further exclusion from the interlinked worlds of education and work.To address this, the EU4ALL project sets forward the concept of Accessible Lifelong Learning (ALL) uniting 3 key strategies:1. That the technology that mediates lifelong learning does so accommodating the diversity of ways people interact with technology and the content and services it delivers2. That this technology is used to bring support services to disabled learners3. Providing support services and technical infrastructure that enable teaching, technical and administrative staff of educational institutions to offer their teaching and services in a way that is accessible to disabled learnersThe aim of EU4ALL is to improve the efficiency and efficacy of implementing these strategies by developing an open service architecture for ALL. To achieve a wide impact the approach taken is not to develop a single EU4ALL system but a standards' based framework that facilitates the integration of the approach with a wide range of eLearning systems.More specifically the goals of EU4ALL are to:-Design an open service-oriented architecture for ALL-Develop the software infrastructure for ALL services (content, support and access services)-Provide technical standards/specifications for ALL applications integrated with current and emerging eLearning standards-Validate the results in large-scale higher education settingsTwo broad u