RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A Multifunctional AgRiculture for SUstainable PerI-urban Areas' (MARSUPIA) under Seventh Framework.

assistant: **Objectives**

Most European and Canadian metropolitan areas are expanding over rural land (i.e. urban sprawl). The loss of prime agricultural land and the proximity of farms to urban land uses has motivated the implementation of land use regulations (zoning). French zoning (decentralized and easily revisable) and Canadian zoning (centralized and strict) influence farmers' perceptions of land access uncertainty. Consequently farmers are assumed to make different investment, production, and marketing decisions depending on their policy context.The MARSUPIA project aims at assessing the impact of land use zoning policies on farmers' investment, production, and marketing decisions, and thus on the supply of local food and agricultural amenities in peri-urban areas.To answer this question, a comparative analysis of the impact of French and Canadian zoning policies is implemented. The methodology is based on a mix of qualitative methods (mental mapping with focus groups) and quantitative methods (econometric analyses using farm individual data). Additionally, recent sampling methods are implemented in order to provide theoretical findings about their validity (dosage methods) as well as to test the robustness of results.This project is a perfect springboard for the principal investigator (PI). This is the opportunity to strengthen his network at UT1 and UoG where he worked as a PhD student and a Visiting Scholar, respectively. He will also acquire new skills: research skills (methodological and theoretical), technical skills (use of new software), language skills (English), and training skills (supervision of master students). Moreover, the publication of research papers in international reviews and recommendations for decision-makers provides an opportunity to improve the visibility of PI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Hydrodynamic electronics'.

assistant: **Innovation**

Advances in fabrication of ultra-pure low-dimensional materials have led in recent years to the emergence of a new area of research -- hydrodynamic electronics. Modern technologies allow for routine manufacturing of ultra-clean samples where observable physical properties are dominated by electron-electron collisions. Electrons in such systems obey the laws of hydrodynamics, which manifests itself in non-local, superballistic, and turbulent transport of energy and electric charge. Following the immense success of graphene research, many novel two-dimensional materials are currently being investigated aiming at potential applications in nanoelectronics, as well as energy conversion and storage. Last years have seen an explosion of interest, both experimental and theoretical, in the hydrodynamic effects in interacting electron systems in ultra-pure materials. The principle aims of HYDROTRONICS are (i) to build a framework to describe hydrodynamic charge and energy transport fine-tuned to the material properties and sample geometry, and (ii) to investigate the physics of novel materials that can be uncovered by transport measurements. Combining the microscopic and macroscopic methods to interacting electronic systems will allow for a unique perspective and yield a powerful approach to transport phenomena that can be easily adapted to new materials and experimental settings, as they become accessible in the course of rapid technological progress. Strong collaboration between the groups involved in the project and its overall synergy will allow novel ideas to flourish, promoting a fertile environment in which early-stage researchers can develop their own paths and resolve the biggest issues in the field. Another important goal is a closer integration between the experimental
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Boosting immuno-oncology strategies with innovative immuno-stimulants derived from bacteria, to be administrated in combination with therapeutic monoclonal antibodies'.

assistant: **Objectives**

Passive immunotherapies are widely used in anti-cancer therapies. However, on average the patient response rates are still weak (20%), and the cure rate without relapse are even lesser (10%). In addition, significant differences exist according to patients, and tumor types. HEPHAISTOS-Pharma develops active and non-specific immunotherapies able to potentiate commercialized antibodies, turning cold tumors hot, thus becoming accessible to immunology. We already obtained an impressive proof of concept on two animal models, first by association with Rituximab for lymphoma, then in monotherapy for osteosarcoma. Our strategy aims at developing our products for open use, as add-on for existing immunotherapies, in order to drastically increase response rates and complete remission. With this aim, we have to test our immunotherapy combined to other monoclonal antibodies commercialized in the relevant cancer models, in parallel to our developments in lymphoma. As soon as the target indication will be defined, we will start the clinical research phase I, in order to demonstrate safety, and define the efficient dose for our immunotherapy. A clinical Phase IIa, combined with Rituximab will be performed, to obtain efficacy data. Our immunotherapy will work in synergy with numerous commercialized therapeutic antibodies, and we will look for strategic deals with the main market leaders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Thermal emissivity of energy-saving coatings on glass - preservation of the measurement infrastructure of the glazing industry (THERMES)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Emissivity, a key property in determining the energy-saving capability of glazing, is determined from the spectral reflectance, traditionally measured using a dispersive (grating) spectrophotometer. Recently, instrument manufacturers have switched over to producing the more modern Fourier Transform (FT) Spectrophotometers instead. For the purpose of the glass industry however, measurements obtained by different FT instruments often disagree significantly and the wavelength range that can be measured in a single configuration does not cover the necessary range. The aim of the project is to(i) obtain a better understanding of these measurements and provide measurement recommendations for the industry,(ii) develop suitable reflectance accessories for these new instruments and(iii) develop an algorithm for predicting the spectral reflectance of coated glass in the missing wavelength range.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The nanoparticle-scope : a new integrated instrument for accurate and reproducible physico-chemical characterisation of nanoparticles (npSCOPE)' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The npSCOPE project aims at developing a new integrated instrument (the nanoparticle-scope) optimised for providing a complete physico-chemical characterisation of nanoparticles both in their pristine form or embedded in complex matrices such as biological tissues. Using sophisticated correlative data processing methodologies and algorithms based on statistical methods in conjunction with appropriate visualisation methods of the results, the npSCOPE instrument will allow rapid, accurate and reproducible measurements.The instrument will be based on the Gas Field Ion Source as a key enabling technology, which we will combine with a number of new developments in the field of electron and ion microscopy. We will progressively ramp up the TRL of the instrument and associated methodologies to reach TRL 7 by the end of the project. The new technology, and all related processes and methodologies, will be validated via round-robin studies performed independently by several partner institutions, crosschecked with conventional analysis technologies to demonstrate the advancements and capabilities of the npSCOPE technology and benchmarked in representative case studies. Given the low sample quantities needed and the strong potential of the instrument to generate high-quality physico-chemical data on nanomaterials, both ex situ and in situ, npSCOPE will allow a major step forward in defining key descriptors for read-across, grouping, in silico modelling and creating meaningful relationships with biological activity data for QSAR purposes.To reach these objectives, the project consortium will be composed of research centres internationally recognised for innovative instrument developments, well-established instrument manufacturers and experts in nanotoxicology in various fields of ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The organisation and regulation of chordate hox genes, and their role in vertebrate evolution' under Fourth Framework.

assistant: **Concept**

The aim of this project is to study the organisation and function of the Chordate Hox genes, and how. they are regulated. This will be done with the model system of Amphioxus. The Hox genes are a family of developmental patterning genes. They are clustered in the genome, and their order along the chromosome reflects the order of their expression domains along the embryonic Anteroposterior axis. This is the phenomenon of Colinearity. Amphioxus is the closest known relative of vertebrates, and is thought to be representative of the vertebrate ancestor. This is because of its simple vertebrate-like body plan. Also Amphioxus has a single Hox gene cluster, whereas vertebrates have four. This lower morphological and genetic complexity should simplify mechanistic analysis, compared to the vertebrates. I will clone the 5' end of the Amphioxus Hox cluster to check its archetypal nature, and to see whether the even-skipped (eve) homologue is linked to it. This will test hypotheses on the presence/absence of eve in the archetypal metazoan Hox cluster and, along with expression data, test whether Chordate eve genes can act like posterior Hox genes by sharing Hox regulatory elements. Hox gene expression data will also clarify how much of the Amphioxus nerve chord is homologous to the vertebrate brain, a question that has been debated for over 100 years. Expression data will also illuminate possible rules for the Hox genes in patterning the mesoderm of Chordates. To find the genes that regulate chordate Hox genes I will use transgenic flies, carrying putative Amphioxus regulatory elements cloned upstream of lac-Z reporter genes. These flies will be crossed to flies mutant for candidate regulatory genes. This work should fill the large gap in our knowledge on the genetic mechanisms co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Design of efficient catalytic nanomaterials as a pillar of a sustainable economy' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The ADVCATALNANOMAT project covers one important topic “the decarbonization of the energy sector” as the core for a sustainable economy. In this direction, the synthesis of methanol and higher alcohols from CO2 and renewable H2 is considered, aiming to increase process efficiency in order to accelerate the deployment of CO2 based technologies. To achieve this, the specific objectives of the project are: i) the design of new catalytic systems based on non-layered 2D metal oxides through topochemical transformation using ultrathin layer double hydroxides (LDH) precursors, ii) optimize the reaction conditions through kinetic studies, iii) establish a relationship between structure and activity to achieve a better understanding of the nature of the active site and its reaction mechanism, supported by mathematical models and theoretical studies, and iv) test and evaluate the performance of catalysts at semi-industrial scale, bridging the gap from the laboratory to a pilot plant.  Innovative materials, with particular surface properties that relates to the coordination number of metal cations, defect sites, high surface area and high metal dispersion will be prepared targeting high alcohol selectivity (C1-C5) in the hydrogenation of CO2. In this direction, multifunctional catalysts containing Cu (for non-dissociative C-O bond activation), Ni (for dissociative C-O activation), and Co (for C-C coupling) will be explored. The success of this proposal lies in the interaction of several disciplines, including material science, the use of advanced spectroscopic characterization tools including Synchrotron Light Radiation tools, chemical engineering and theoretical simulation. All these will support the proposed research and provide the necessary knowledge for the design of new cata
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Asexual reproduction through clonal seeds: mechanisms to application' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Some plant species have abandoned sex and produce clonal seeds by apomixis; here, we will explore how this occurs, and exploit these insights to develop novel breeding technologies. In contrast to most eukaryotic species in which reproduction is sexual, a minority of plants and animals have evolved alternative – asexual – reproductive strategies. In plants, apomixis allows clonal transmission of favorable, hybrid genotypes through seeds over unlimited generations. Hybrid crop varieties are stress-resistant and high-yielding due to hybrid vigor, yet they reproduce sexually. The introduction of apomixis in hybrid crops would allow stable inheritance of hybrid vigor through seeds, in perpetuity, and eradicate the need to continuously re-make hybrids by crossing. However, our knowledge of the genetic and molecular basis of apomixis remains incomplete, and blueprints for synthetic apomixis in crops must be established.This project will decipher the function and evolution of a novel PARTHENOGENESIS gene that I recently demonstrated causes asexual embryo formation in naturally apomictic dandelions. Harnessing and extending fundamental findings, synthetic apomixis systems will be developed in two important vegetable crops – hybrid lettuce and tomato – allowing the full complement of hybrid traits to be faithfully inherited through seeds. Ultimately, apomixis in crops could revolutionize the €22 billion hybrid seed industry, make hybrid seeds readily available for all, and facilitate sustainable, high-performance agriculture around the world.Specifically, this project will involve:1) Deciphering how a PARTHENOGENESIS gene homologue functions during sexual reproduction2) Optimizing the expression of PARTHENOGENESIS factors through evolutionary insights and mutagenesis3) Engineeri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European climate of the last millennium' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Millennium will answer one of the most critical questions in climate research: does the magnitude and rate of 20ᵗʰ Century climate change exceed the natural variability of European climate over the last millennium? Existing climate reconstructions rely on inadequate data and underestimate variability. Improved GCM parameterization requires more accurate reconstructions and integrated modelling. We will supply high-resolution chronologies that capture the magnitude and rate of change and the magnitude and frequency of extreme events over the last 1000 years. Our multi-disciplinary team will use innovative and developing technologies to extract quantitative palaeoclimate information from documentary and natural archives, including trees, lakes, mires and ice cores. A multi-proxy approach provides seasonal palaeoclimate signals with quantified precision. Advances in dating allow us, for the first time, to place terrestrial and marine proxy records on the same timescale, allowing lead and lag relationships in ocean-atmosphere forcing to be captured. Annually banded seashells will be cross-dated like tree rings, and tephra-rich sediments used to construct a marine chronology independent of ¹⁴C dating. This can be used to reconstruct changes in ventilation linked directly to the strength of North Atlantic circulation. Millennial reconstructions of European climate, at a range of scales, will define whether recent climate change is unusual in the context of past variability. Millennium proxy-based reconstructions will be fused with a hierarchy of models, run over both millennium and century time scales using a purpose-built PC cluster and the huge resources of the Climateprediction.net distributed computing network. Integrated hind- and forecast modelling, (using HadCM3) will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for '“DNA-based NANOdevices for the point-of-care electrochemical detection of AntiBodies”' to be submitted under Horizon 2020.

assistant: **Abstract**

WHY: Antibody detection plays a pivotal role in the diagnosis of many human disorders including infectious, autoimmune, and oncological diseases. Unfortunately, current methods routinely used for the detection of these biomarkers still require sophisticated equipment, washing intensive, reagent-intensive multi-step processes. In attempt to overcome the cited limitations, it’s mandatory find new approaches for the sensitive detection of antibodies. WHAT: DNA-NANO-AB proposes the development of DNA-based novel, rapid, user friendly, robust, sensitive and low cost electrochemical NANOdevices for orthogonal multiplex detection of antibodies that may be advantageous over existing methods for the detection of clinically-relevant antibodies and could be well-positioned for point-of-care applications. I will achieve this goal by rationally designing and fabricating disposable DNA-based sensing platforms in which the detection of specific antibodies will be signaled, and amplified, through an electrochemical read-out approach. The developed platforms will be characterized, optimized and then tested for the dosage of immunoglobulins levels directly in real representative samples. HOW: During the fellowship I will undertake a training program to develop skills and acquire expertise in molecular biology, electrochemical biosensor and DNA Nanotechnology. To achieve these objectives, I will combine the different scientific backgrounds and expertise of two leading scientists: Prof. Plaxco (University of California Santa Barbara), a world-wide expert in electrochemical biosensors, and Prof. Ricci (University of Rome, Tor Vergata), a young researcher active at the forefront of DNA nanotechnology for diagnostic and drug-delivery applications. Thanks to this MSC Fellowship, I will diversi