RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of a New Wavelength Scanning Interferometer for Embedded Metrology' to be submitted under Horizon 2020.

assistant: **Abstract**

The proposed EMInstr project aims to elevate the important research result, a lab prototype of a new wavelength scanning interferometer (NWSI) developed during the ERC-2008-ADG 228117 SURFUND project and to verify its potential as a commercial product. The EMInstr project intends to set up a commercialisation pathway: from verification/validation of the lab prototype, through to technical optimisation, product prototype design, technological licensing and finally into commercialisation. The expected result of this project is to develop a new generation instrument, a pre-production NWSI, for embedded metrology.The NWSI represents a step-change in manufacturing metrology instruments, being the first of a new generation of micro/nano geometry and surface topography measurement systems. This revolutionary device is the result of integrating several advanced technologies, wavelength/frequency scanning, GPU electronics and a multi-interferometry configuration, to produce the NWSI with unique capabilities in high-speed, large-measurement ratio (range/resolution) and robustness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Chemistry informed machine learning in emulsion polymerization processes and products' in the context of a Horizon Europe call.

assistant: **Objectives**

Machine learning (ML) systems continue to revolutionize many aspects of daily life, but despite their immense potential have yet to impact significantly in polymer science. One major issue that is hindering the more widespread use of machine learning in polymer science, and many other physical sciences, lies in the challenges in amassing sufficient data to efficiently train machine learning models. This in itself is not necessarily a problem, and is an issue frequently encountered in the machine learning field, but can only be resolved by a thorough understanding of the science behind the problem of interest. CINEMA aims to providing a training platform that will allow the next generation of polymer scientists to take polymer science into the 21st century through incorporating the fundamental knowledge gained over many years of research into the training of machine learning systems. Such a knowledge-driven machine learning approach puts the scientific issues of CINEMA at the forefront of the use of machine learning in fundamental scientific problems, and also provides the perfect training platform for the next generation of scientists, for whom the use of AI will be an invaluable tool.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Differential equations with applications in science and engineering' to be submitted under Sixth Framework.

assistant: **Abstract**

The goal of the DEASE project is to create a multinational and multidisciplinary Early Stage Training site (mEST) where the partners run a joint PhD training programme" in a core field of Applied Mathematics: (Partial) Differential Equations are the basic mathematical description for many phenomena in physics, biology and other fields of basic science as well as in (fluid) mechanics, nanotechnology and other fields of engineering and technology.Based on well established local "doctoral schools'' that have already passed a most rigorous peer review, both for the excellence and the relevance of the field, relatively little additional funding of the EC is used in order to enhance the impact of these PhD training sites on a European level and to implement new transnational training structures to foster the European Higher Education Area (EHEA) and the European Research Area (ERA). The 5 participating teams in 4 countries compose a carefully selected consortium: the WPI Vienna, the ENS in Paris/Cachan, the MIP in Toulouse, the TU/Uni Hamburg-Harburg and the FORTH in Heraklion have all a strong track of successful participation in international research training projects that are now adapted to the goals of FP6.The participating senior scientists are mathematicians, many of them with a strong background in physics and engineering, as well biologists and engineers. About 50 "young researchers" will directly profit from the funding of this mEST in order to receive training on a high level of excellence, covering all the 3 intertwined aspects of modern applied mathematics: Modelling +Analysis +Numerics. Additional training in fields of applications and in skills like teamwork, project management, ... shall make the participating PhD students fit and mobile for lea ding positions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'High-throughput, fully automated and cost-effective behavioural phenotyping of normal, clinical and genetic mouse models' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Behavioural change is the most sensitive biological end-point signalling any alteration in the organism of a mouse. However, large-scale bio-assays of behaviour face limitations: outdated technology, need for space and specialized manpower, lack of standardisation, and increasing legal demands on animal husbandry. This has limited the use of behavioural methods to specialised laboratories, limiting the market as well. In order to advance scientific progress and expand the market, 2 SME's and 1 academic partner will combine their existing expertise and products for behavioural phenotyping to generate a compact modular system, INTELLIMAZE. This system should fit into a single small mouse room, where it will - Assess home cage activity and learning of transponder-tagged mice living in social groups - Analyse automatically social behaviour - Guide individual mice to a battery of traditionally used tests - Show ongoing learning on-line to a supervisor working in his office - Analyse data according to expert knowledge-based rules - Provide a web-based analysis of results for user groups. The bottleneck of such technological development is functional validation and comparison with traditional tests. Three academic partners will use the novel technology for a) generating new mouse models of depression, b) profiling malfunctions of specific brain systems, and c) monitoring the effects of age-dependent neurodegeneration in existing and new mouse models. Finally, an SME partner in need of efficient behavioural phenotyping will validate the novel systems for drug discovery and development. We expect that the availability of simplified, rapid and thorough behavioural testing of mice without need for specialized personnel will open new and larger markets for the SME's. Moreover we pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Integrated expert system for waste water management efficiency control', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The Project objective is to design and develop an innovative integrated and expert management system, for urban and industrial wastewater with prevalent organic load, capable to: Improve, at least of the 30%, the efficient use and control offal resources to minimise wastage; Reduction of environmental impact at least of the 25%; Prevention of environmental disasters: early warning system; Reduction retrofitting, at least of the 15%, and optimisation of wastewater systems; Reduction of process management costs at least of the 15%; Reduction of professional training costs of 50%. The system will be composed of 3 main functional modules:1) Management Expert Unit, including a diagnostic expert system and a system for active maintenance. It will be based on a territorial management system (e.g. GIS).2) Information Unit, allowing a reliable and controlled information diffusion to all responsible parties in charge of the management and emergency operations.3) Training Unit, for the training of Water companies and Water operators.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Second implementation project for the ERIC Forum' under Horizon Europe.

assistant: **Concept**

The ERICs (European Research Infrastructure Consortia), under the umbrella of the ERIC Forum, represent one of the leading science policy voices in Europe and play a key role in structuring the research infrastructure landscape. Following the successful set-up and implementation of the ERIC Forum (2019-2022), further efforts are needed to consolidate its achievements and expand the coordination and monitoring of the ERICs. This  project aims to structure the cooperation between ERICs, support the implementation of the ERIC Regulation and ERICs services, and consolidate the integration of the ERICs in the European Research Area by deepening the ERIC Forum’s contribution to research policies.To reach its objectives, the project relies on a multi-disciplinary consortium involving all identified ERICs, both multi- and single-sited, and representing the five science clusters of the ERICs.The project is structured in four thematic pillars: 1) Monitoring and Reporting, 2) Reinforcing European research infrastructure policy and international cooperation; 3) Implementing the ERIC Regulation, strengthening capacities and identifying possible shared resources; 4) Coordinating the project, ERIC Forum Executive Board secretariat and communication.The activities carried out within the project will ensure the implementation of specific results on three key target groups: the ERICs and ERICs-to-be, in order to increase their knowledge and propose solutions for key aspects of the ERIC Regulation implementation; the policy-makers and stakeholders by setting-up and managing the new ERIC Forum monitoring and reporting platform, thus ensuring an easy access to updated and consolidated data and information about the ERICs, as well a further strengthened role in the European science policy; a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Method for improving the quality of frozen foods by assisting the freezing process and reducing the size of the ice crystals' (MINICRYSTAL) targeting Seventh Framework.

assistant: **Abstract**

Freezing is a very widespread process within the food processing industry, being used not only to manufacture products that are consumed in frozen state, such as ice cream, frozen yoghurts, sorbets, etc, but also as a very important means of preserving fresh foodstuffs. However, freezing animal and plant tissues causes many irreversible physical and chemical changes within the food matrix, often leaving the final product with lower eating quality than when it was in the fresh state. Ice crystals represent one of the key contributors to quality degradation in frozen foods. As they grow in size, they exert additional stresses on fragile cellular structures and can damage emulsions and lead to negative product characteristics such as poor appearance, unacceptable texture and physical and nutritional product damage. In short, smaller ice crystals promote a better quality product and control of the crystal size distribution in the final product is one of the most important aspects for many freezing operations.  As quality issues take increasing precedence among EU consumers, a key challenge facing frozen food manufacturers is how to reposition their products as health-friendly. Consumers not only instinctively believe that fresh food tastes better than frozen food- they also see frozen foods as cheap and inferior. In response, this project will build upon promising research in the ability of high powered ultrasound (HPU) to initiate ice nucleation and to control crystal size distribution in the frozen product during solidification of liquid food. Past research has also shown promise for HPU to shorten the freezing process and lead to a product of better quality. This project will design and develop a prototype HPU system for its industrial validation in food freezing facilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Role of the chylomicron and HDL pathways in the development of obesity and insulin resistance'.

assistant: **Concept**

Apolipoproteins and lipoprotein modifying enzymes are responsible for the maintenance of lipid homeostasis in the circulation. Mutations in these proteins may affect the lipoproteins present in plasma and may result in dyslipidemia. Obesity plays a central role in the development of the metabolic syndrome. Our data indicate that apoE promotes diet-induced obesity. Based on this, we hypothesize that components of the lipoprotein system that promote direct delivery of lipids to the peripheral tissues will contribute to the development of obesity and insulin resistance; in contrast, components that promote reverse lipid transport may prevent these conditions. Thus, we propose to investigate the role of the chylomicron and HDL pathways in the development of obesity and insulin resistance. Our objectives are: 1) To determine how expression or lack of expression of apolipoproteins or lipoprotein modifying enzymes in transgenic and knock-out mice affect diet-induced obesity, and type II diabetes. In this objective, mice deficient or transgenic for proteins of the chylomicron and HDL pathways will be placed on western-type diet and their weight, body composition, and sensitivity to insulin will be determined over time. 2) To identify cellular genes and pathways that are affected by apoE and other components of the lipoprotein transport system and may promote or prevent adopigenesis. In this objective we propose to use microarray analysis, to identify signaling pathways affected by apoE and other proteins of the lipoprotein system. Select target genes that will be identified from this analysis will be expressed in cultured preadipocytes using adenoviral vectors, to validate their functional role in preadipocyte differentiation, lipid deposition, and the development of insulin re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of the circuits in the locust brain for the early detection and avoidance of looming objects' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Looming detection is crucial for animals to efficiently respond to approaching stimuli. Extensive research has been done to characterise and understand the neural circuits underlying such capacity. The locust has been established as a preferred model because it has a pair of large and uniquely identified visual neurons, the lobula giant movement detector (LGMD) and the postsynaptic descending contralateral movement detector (DCMD) that respond selectively to the images of an object approaching towards its eye. These neurons have been associated with the triggering of last moment avoidance responses such as gliding dives during flight. So far, all studies have used adult locusts. However these animals avoid predation by birds throughout their lives and the preferred escape response varies during development. Juvenile locusts display escape behaviours on the ground, such as hiding and jumping, that require more time than emergency dives and therefore are triggered early in the loom. DCMD may have a role in guiding these early reactions as it starts responding long before collision. However there have been no attempts yet to record from the DCMD during hiding. The present research aims at characterising the visual cues that produce the hiding response in the adult and studying the possible involvement of the LGMD and DCMD neurons in such behaviour. It also intends to quantify the behavioural strategies displayed at different stages of the locust’s life, relating them to the development of the neural circuit involved in looming detection. For this study we will use electrophysiological recordings in juvenile and adult locusts. We will also study the ultrastructure and synaptic connections during development, and relate it to what is already known in the adult. This may lead
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Labs for prototyping future Mobility Data sharing cloud solutions' (MobiDataLab), addressing dissemination and exploitation.

assistant: **Impact**

The overall objective of MobiDataLab is to propose to the mobility stakeholders (transport organising authorities, operators, industry, innovators) a replicable methodology and sustainable tools that foster the development of a data sharing culture in Europe and beyond. MobiDataLab is based on a continuous co-development of knowledge and of technical solutions for data sharing with high involvement of all data producers and consumers in the transport and mobility landscape. This will be put in action through problem-solving oriented Labs, the collection and analysis of advice and recommendations of experts and supporting cities/regions/clusters/associations aided by the incremental construction of a cross-thematic knowledge base and of a cloud-based service platform, which will federate access and usage of data sharing resources. MobiDataLab leverages on the legal, technological and economic opportunities to:- present mobility data providers with recommendations on how to improve the quality, accessibility and usability of their data - how to describe them, how to store them safely and securely, how to make them available, easy to find, and understandable;- encourage the reuse of these data and foster users’ trust in the data, contributing to the development and promotion of open tools to the community of innovators;- bring together mobility stakeholders (both data providers and data consumers) to find innovative solutions to concrete problems, using open data as a tool.The MobiDataLab consortium is formed by 10 partners from Industry, Research, Academia, Consultancy and Governance sectors, located in 7 countries. The consortium shares a common view on the values and benefits of open data and open source principles for fostering independence and uptake by communities. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'cryo-EM structures of a Gram-positive type 4 secretion system'.

assistant: **Concept**

Gram-positive (G+) bacteria, such as the Enterococcus species faecium and faecalis, cause around half of hospital-acquired infections. These infections are increasingly antimicrobial-resistant (AMR), which presents a major challenge for tackling the global burden of disease. AMR arises from mutant genes, which can be inherited, and also spread between bacterial species by conjugation through type 4 secretion systems (T4SS), which are protein complex. T4SS are an attractive target for new antibioitics, but development has proven difficult without detailed structural information on these molecular machines. Information is especially lacking for G+ species, which we will address.This project will use cryogenic electron microscopy and tomography to study the T4SS of E. faecalis and obtain the first high-resolution and in situ structures of any G+ T4SS, combining my experience with the cryo-EM of membrane protein complexes and the host’s expertise in G+ T4SS. We will reveal the molecular architecture of a critical conjugation machine and its network of protein-protein interactions. This will enable the precise mechanism of gene transfer and essential (targetable) proteins to be determined.


**Keywords:** cryo-EM, tomography, Gram-positive bacteria, membrane proteins, DNA transporters