RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Improving equity in access to early diagnosis of cancer: implementation research in different healthcare systems of Latin America (EquityCancer-LA)' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Healthcare fragmentation is a main cause for delay in cancer diagnosis and treatment, contributing to high and steadily increasing mortality rates in Latin America(LA), particularly among disadvantaged populations. Building on Equity-LA I (GA223123) and II (GA305197), this research focuses on integrated care interventions, which have proven effective at improving early diagnosis of cancer, mostly in HIC, and are also promoted by national cancer plans in LA, but limitedly implemented or evaluated. The objective is to evaluate the contextual effectiveness of scaling-up a multicomponent integrated care intervention to improve early diagnosis of frequent cancers in healthcare networks of Chile, Colombia and Ecuador. Method: This participatory, interdisciplinary and mix-methods implementation research is two-pronged: a) a quasi-experimental design (controlled before and after) with an intervention and a control healthcare network; b) a case study design. Focussing on the most vulnerable socioeconomic population, it develops in four phases: 1) analysis of delays, related factors and contextual barriers to early diagnosis (base-line); 2) adaptation and scaling-up of the intervention (PC training, fast-track referral pathway and patient information, adapting available ICT tools) in real life; 3) intra-country evaluation of intervention; 4) cross-country analysis. ICT tools will be also adopted in research activities as needed in a Covid-19 on-going or post- pandemic context. Relevance: EquityCancer-LA contributes to H2020 call objectives advancing cancer control policies by generating: 1) robust evidence on contextual effectiveness and costs-effectiveness of an affordable, tailored intervention to reduce diagnostic delays; and a validated strategy for its large-scale implementa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Construction of a Genetic System for Planctomycetes' (COGNISEPLANCTOMYCES).

assistant: **Innovation**

Due to the emerging resistance of bacterial pathogens against commonly used drugs, there is an urgent requirement for new antibiotic compounds and lead structures. The European Commission encouraged researchers to investigate this problem in a holistic manner. Recently bacteria with complex lifestyles and intensive “crosstalk” came into focus as potential source for new small molecule lead structures which might be further developed as therapeutic agents. Planctomycetes comprise ideal candidates, since these ubiquitous occurring organisms, which reproduce via budding, form cell aggregates, such as biofilms and “marine-snow”. Beside their complex lifestyle, they comprise sub cellular compartments resembling the eukaryotic nucleus which questions the pro-/eukaryotic dichometrie. Thus, they combine a complex lifestyle with interspecies communication, which is required for biofilm formation. However, in-depth analysis of Planctomycetes secondary metabolite production has been hampered by the lack of a genetic system. Consequently the major objective of this proposal is the construction of a genetic system for Planctomycetes. Such a system would allow e.g. the construction of deletion mutants and the identification of secondary metabolites while comparing these mutants against the wild type strain. In addition the genetic system will be highly beneficial for applications beyond the proposed project, since e.g. genetic modification of Planctomycetes which play an important role in waste water treatment will result in further biotechnological applications. In addition to the development of the genetic system, the capability of small molecule synthesis will be investigate via genome mining of the already sequenced Planctomycetes species. Further more surrogate genetic experimen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sustainable and healthy food solutions: system dynamics and trade-offs' (FLORA), addressing dissemination and exploitation.

assistant: **Impact**

Food systems are crucial to end hunger, but also to mitigate and adapt to climate change, to protect and restore biodiversity, to ensure human health and well-being, to end poverty, and to support sustainable communities. While hunger has receded, food systems are causing increasingly severe damage to our environment and health. The FLORA project will contribute to a transformation of global agri-food production, trade, and consumption necessary to achieve sustainable and healthy food systems.The project will create essential evidence to identify and implement the shifts in practices and behaviours needed to effectively achieve this transformation, by (1) making a diagnosis of the integrated health and environmental outcomes of food systems globally, from the production and consumption perspectives, with innovative measures of sustainability, (2) identifying key threats and opportunities with system dynamics and complex network analyses, and (3) targeting and evaluating tailored solutions with an inter-disciplinary modelling framework. The project will enable the identification of most effective, targeted solutions by considering trade-offs, synergies, and dynamics of key food systems components. Global in scope, it sets the ambitious goal to overcome barriers in current approaches by taking a systemic approach and establishing a robust, interdisciplinary framework supported by empirical advancements to tackle complex food systems challenges. This innovative project builds on the PI’s excellent track record in leading interdisciplinary research focusedon the global agri-food system and its environmental impacts.


**Keywords:** food systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Exploitation of the SECRETory pathway for cancer therapy to address European research' (SECRET).

assistant: **Innovation**

Breast and colorectal cancer (BC and CRC) are the most frequent cancers accounting for 19% of all deaths from cancer in Europe. In case of triple-negative BC (TNBC) targeted therapies are not available and non-selective chemotherapy is the only treatment option. Targeted therapy has been approved for the treatment of advanced CRC, but response rates are low and treatment is limited to a subgroup of patients. Also, TNBC and CRC patients are prone to develop metastases and have a poor prognosis underpinning the need for new targeted and broadly applicable therapeutic strategies. Tumor cell secretion contributes to hallmarks of cancer e.g. hyperproliferation, evasion of growth suppression, loss of cell polarity, activation of cell motility, invasion and metastasis, shaping of the tumor microenvironment through altered presentation of proteins and the secretome, and resistance to cell death. Dysregulated secretion is thus a driver of cancer progression and therefore holds promise as a general therapeutic target for the treatment of cancers. However, strategies to exploit the secretory pathway for therapeutic and diagnostic purposes are still in their infancy due to the incomplete understanding of how this pathway is regulated by aberrant signaling. The overall research objective of SECRET is to drive the understanding of the mutual regulation of the secretory pathway and signaling in cancer, which will serve as a platform to identify and interrogate novel diagnostic and therapeutic strategies. SECRET comprises 11 beneficiaries and 7 partner organizations from 9 countries. Coordinated by the University of Stuttgart, SECRET will train 15 talented ESRs in the field of translational cancer systems cell biology and systems medicine towards a career in industry or academia throug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Polar-to-mid-latitude climate linkage effects on cold air outbreaks' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Cold air outbreaks are a typical feature of the mid-latitude climate during the cold season. Their relevance relies on the threat to life caused by the long-lasting periods with abnormally low temperatures as well as on the potential of damage to crops and the occurrence of high-impact weather events such as heavy snow and low visibility during blizzards. Previous studies have documented the linkages between climate variability at high latitudes with that at mid-latitudes mainly through modulation of the storm tracks, jet streams and patterns of stationary waves which promote blocking events. The role of other components of the climate system, like sea ice, is much less understood and remains an open question. This becomes even more challenging under the current conditions of fast sea ice reduction in the Arctic and the significant trends observed in sea ice around Antarctica, which leads to an increase in uncertainty in the area of sub-seasonal to interannual climate predictions as well as for climate projections for the coming decades. Furthermore, significant biases currently exist in the representation of sea ice in state-of-the-art climate model simulations.The main objective of this proposal is to analyze the physical mechanisms linking variability at high latitudes (including that of sea ice) with climate variability at mid-latitudes. Special focus will be driven onto the mechanisms promoting cold snaps at mid-latitudes and on their variability. To this aim, this project will make use of a data set of very-high-resolution coupled global climate model simulations (at around 10 km) which is expected to bring significant improvements to the representation of sea ice as well as to its linkages with other components of the climate system. Outcomes of this project are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Highly durable precast special concrete reinforced with non metallic rebars', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives and content: At present, construction methods are being more and more diversified, and precast concrete applications are increasing day by day, especially in countries where concrete manufacturing technologies are not developed. However, in the case of plane concrete elements, geometry of these pieces oblige to the maintenance of a low cover depth, which do not confer enough protection to the steel reinforcement when they are exposed to aggressive environments. In some cases, these elements are exposed into electric fields (railway crossings), creating erratic currents, which seriously damage metallic rebars. For this reason, a market survey by constructors has shown that there is a strong industrial need for the development of new types of precast plane reinforced elements, for architectural and structural purposes, which could be reliably used in aggressive environments or when electrical isolation is required.The industrial objectives of these projects are:- Improving durability of precast plane reinforced elements in 70% by the use of non-metallic rebars;- Development new technologies for precast concrete, more competitive, towards U.S.A. and Japan;- Diversification of construction solutions, through the introduction of new constructive precast systems;- Reduction of thickness and weights of the elements in 15 % with the same or improved properties;- Offering new competitive products being able to be reliably worldwide applied in all climate conditions;- Avoiding of maintenance and repair costs (reduction to 0) for non-metallic reinforcement;- Design and development of a new reinforcement with non-metallic rebars for cement and polymer concrete;- Development design procedure for both cement and polymer concrete elements reinforced with plastic bars. The p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Encompassing Training in fUnctional Disorders across Europe'.

assistant: **Objectives**

Functional Disorders (FD) are clusters of chronic somatic symptoms that currently cannot be associated to reproducibly observable pathophysiological mechanisms. FD can affect every organ system, individuals of all ages, ethnic groups and socioeconomic strata, although the risk is increased in women and lower socioeconomic strata. Women are 9 times more likely to receive an FD diagnosis, even after adjustment for the severity of symptoms. Functional limitations are as severe in FD as in well-defined chronic physical diseases. Direct medical costs and indirect costs as a consequence of sick leave and disability are high. FD cause relevant annual excess costs in health care that are comparable to mental health problems like depression or anxiety disorders, and which may be reduced by interventions targeting physicians as well as patients. About 7% of the population is affected to such a degree that they qualify for psychiatric treatment. However, this remains hidden due to diagnostic practices that vary between fields. Psychosomatic medicine, clinical psychology and medical specialties all have their own and different concepts of FD having important consequences for patients. These challenges result in a lack of knowledge on FD, leading to fragmented and insufficient health care for patients with FD, and a society in which patients with FD experience stigma from both the society as well as from health care professionals. There is an urgent need to solve the fragmented and insufficient education and research landscape.Therefore, the goal of ETUDE is the development of a sustainable and structured training programme in order to educate a new generation of interdisciplinary creative early stage researchers that are able to cross disciplines and to translate theory and experim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Evaluation and network of ec-decision support systems in the field of hydrological dispersion models and of aquatic radioecological research' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Several computerised Decision Support Systems (DSS) have been developed for the management of contaminated fresh water environments.The objectives of the proposed network are:a) to review and assess the DSSs to ensure that they comply with expectations and needs of potential users;b) to identify and classify the approaches of the different DSSs;c) to define their application domains;d) to synthesise the experience gained for improving the DSSs and for the rational utilisation of the existing products.The DSSs will be assessed by inter-comparison and testing in view of the needs of the user community. User groups and experts from environmental protection agencies and administrations and from the international scientific community will be involved in DSS exercises. Recommendations for the improvement and the rationale of the DSSs and of their components (models, methodologies, software products) will be supplied to provide the end-users with easy to use and reliable tools for the environmental management.During the IV EC framework programme, several projects focused on developing computerised Decision Support Systems (DSS) for the management of contaminated fresh water environments.These DSSs have been, in most cases, implemented in computer codes based on:a) Models to predict radionuclide behaviour in the aquatic environment;b) Methodologies for the assessments of the economic, social and ecological impacts of both contamination and remedial measures.The objectives of the proposed network are:a) to review and assess the DSSs to ensure that they comply with expectations and needs of potential users;b) to identify and classify the approaches of the different DSSs;c) to define their application domains;d) to synthesise the experience gained for improving the DSSs and for th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'TransformDairyNet: Working together to upscale Cow-Calf-Contact dairy production and beyond' (TransformDairyNet) under Horizon Europe.

assistant: **Objectives**

TransformDairyNet will harness the expertise of 26 European partners to create 11 National Innovation Practice Hubs and a European Knowledge and Innovation Network of dairy farmers, veterinarians, advisors, supply chain actors, farmer organisations, researchers and policy makers, to work together to upscale cow calf contact (CCC) dairy production and beyond. Keeping cows and calves together for months rather than the usual hours/days promotes health, growth and normal, pleasurable behaviour, and is the most consumer accepted ethical practice for increasing the sustainability of dairy systems in line with the Green Deal.TransformDairyNet aims to accelerate the adoption of CCC orientated-practice through: (1) compiling existing knowledge and identifying end-user needs; (2) co-creating new CCC knowledge–generating ideas and solutions; (3) sharing knowledge ready for practice, and (4) CCC legacy and tools for transforming systems. Through a multi-actor approach, TransformDairyNet will bring science and practice together to create a comprehensive CCC knowledge map, champion farmer-led innovation and share practice to upskill European dairy farmers and advisors at differences stages of adoption. TransformDairyNet will build resilience and normalise and spread CCC practice by co-creating harmonised, farmer–facing tools, materials and peer-to-peer activities, leveraging trusted channels and networks and engaging with existing and new dairy and CCC focused EIP-AGRI Operational Groups. TransformDairyNet will work with EU FarmBook to maintain the Knowledge and Innovation Networks beyond the project as a community of practice, able to pivot to other issues for the continued transition to sustainable dairy production into the future. Looking forward, TransformDairyNet will provide i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'REusable MAsk Patterning' (REMAP).

assistant: **Innovation**

Surface patterning is crucial for the progress of key enabling technologies (KETs) such as advanced manufacturing, microelectronics, nano/biotechnology and photonics. The current paradigm in surface patterning is optical projection lithography (OPL), a paradigm designed for high-resolution. However, emerging green technologies like micropatterned photovoltaics (PV) require high quality patterning at scale/throughput that is hardly attainable by OPL economically and sustainably. Importantly, half-pitch resolutions on the tens of μm-scale are totally acceptable for such applications, which does not justify the use of high-end OPL. In these cases, OPL is unsuited, because it relies on disposable masks with extremely high embodied energy. While the key asset of OPL is the mask, it is the component that currently makes it low-throughput and energy/material inefficient. Extensive efforts have been directed to develop maskless strategies, but most fall short when it comes to throughput and design flexibility. REMAP envisions a radically new and green surface patterning technique based on the spontaneous formation of reusable magnetic masks. Such masks are possible using fully adjustable and reversible interactions of ""magnetorheological electrolytes"" (MRE) on a substrate and microstructured magnetic fields generated by a permanent array of electromagnets below the substrate. By selectively activating each micro-electromagnet, it is possible to modulate the intensity and shape of the magnetic field (hence the mask) over space and time. This way, REMAP enables high-throughput area-selective additive and subtractive patterning on a surface at room temperature and pressure. Furthermore, the newly devised MREs and the tuneable magnetic array developed within REMAP will pave the w