RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dissecting to hit the therapeutic targets in nucleophosmin (NPM1)-mutated acute myeloid leukemia' (NPM1) under Horizon 2020.

assistant: **Objectives**

Acute myeloid leukemia (AML) is a group of hematologic malignancies which, due to their molecular and clinical heterogeneity, have been traditionally difficult to classify and treat. Recently, next-generation, whole-genome sequencing has uncovered several recurrent somatic mutations that better define the landscape of AML genomics. Despite these advances in deciphering AML molecular subsets, there have been no concurrent improvements in AML therapy which still relies on the ‘antracycline+cytarabine’ scheme. Hereto, only about 40-50% of adult young patients are cured whilst most of the elderly succumb to their disease. Therefore, new therapeutic approaches which would take advantage of the new discoveries are clearly needed. In the past years, we discovered and characterized nucleophosmin (NPM1) mutations as the most frequent genetic alteration (about 30%) in AML, and today NPM1-mutated AML is a new entity in the WHO classification of myeloid neoplasms. However, mechanisms of leukemogenesis and a specific therapy for this leukemia are missing. Here, I aim to unravel the complex network of molecular interactions that take place in this distinct genetic subtype, and find their vulnerabilities to identify new targets for therapy. To address this issue, I will avail of relevant pre-clinical models developed in our laboratories and propose two complementary strategies: 1) a screening-based approach, focused either on the target, by analyzing synthetic lethal interactions through CRISPR-based genome-wide interference, or on the drug, by high-throughput chemical libraries screenings; 2) a hypothesis-driven approach, based on our recent gained novel insights on the role of specific intracellular pathways/genes in NPM1-mutated AML and on pharmacological studies with ‘old’ drugs,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular pathways underlying decreased beta cell mass in diabetes mellitus' (SAVEBETA) under Sixth Framework.

assistant: **Objectives**

The two main forms of diabetes are type 1 and type 2 diabetes (T1D & T2D). They affect 30 million individuals in Europe, decreasing their life quality and expectancy. A reduction in pancreatic beta cell mass, caused by increased apoptosis and defective regeneration, is a key component of both T1D and T2D. The molecular mechanisms underlying decreased beta cell mass remain to be clarified. Molecular signalling in the beta cells is decisive for their survival or death in diabetes. We hypothesize that crosstalk between key gene networks and insufficient protective responses, due to inherent features of beta cells, trigger the apoptosis program and prevent regeneration. The aim of this proposal is to utilize functional genomics to identify pathways responsible for the reduction of beta cell mass in diabetes, and use this knowledge to define targets for intervention to preserve beta cell mass.  This will be reached through the following steps:  (1) Identification of the regulatory molecular pathways that control physiological beta cell mass through regeneration, differentiation and apoptosis.  (2) Use of functional genomics to identify key patho-physiological events in the above pathways that are responsible for reduction of beta cell mass in diabetes, with focus on the mechanisms regulating cytokine- and glucolipotoxicity-induced beta cell apoptosis.  (3) Intervention in the defective signal transduction pathways identified above using genetically modified mice, long-acting viral vectors and small interfering RNAs.  This step should identify and validate targets to preserve beta cell mass in diabetes. To achieve this goal, a consortium of leading European experts in the fields of beta cell diabetes research, functional genomics and bioinformatics has been established. The r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Deep multi-scale modelling of electrified metal oxide nanostructures' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

One promising solution toward a sustainable society and a green economy is to use metal oxide-based materials. Metal oxides are a class of inorganic materials that have various energy and environmental applications such as heterogeneous catalyst, fuel cell, lithium-ion battery, supercapacitor, water treatment and antimicrobial application. Most metal oxides are synthesized as nanostructures which leads to unique properties and reduced economical costs. The very properties that make the metal oxide nanostructures attractive and indispensable in modern science and technology also cause an issue for the environment and human safety.  In both the functioning and the degradation of metal oxide nanostructures, aqueous interface plays a vital role. The metal oxide-aqueous solution aqueous interface is electrified in working conditions due to acid-base chemistry and composed of protonic electric double layer. Given the importance of metal oxide surfaces in practical applications, surprisingly little is known about the relation between atomic structure of protonic double layer and the interfacial reactivity.  This is largely due to the fact that our knowledge is mostly based on macroscopic observations such as current and concentration in electrochemistry and microscopic information of protonic double layer is difficult to be obtained in experiments. Therefore, developing a novel deep-learning empowered multi-scale modelling framework and providing a revolutionizing understanding at microscopic level of the functioning and degradation of electrified metal oxide nanostructures are the aims of this proposal.  The outcome of this project will not only lead to the knowledge discovery about the impact of protonic electric double layer on porous metal oxide-based supercapacitors and o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integrated Sink Enhancement Assessment' (INSEA) under Sixth Framework.

assistant: **Objectives**

Working group 7 (Agriculture) under the European Climate Change Programme has so far mainly dealt with mitigation potentials of GHG. A thorough integrated economic and environmental assessment in the area of agriculture and sinks has not yet been carried out. In order to support the international negotiation process and for the development of good policies the Integrated Sink Enhancement Assessment (INSEA) project's objective is to develop an analytical tool to assess economic and environmental effects for enhancing carbon sinks in agriculture and forestry. The approach is centurion spatially explicit databases that will allow the calculation of cost-landscapes" taking on an engineering approach to integrated costs computation of additional sink enhancement measures and negative emission technologies. The various model structures will be applied to detailed European data sets and less detailed global data sets assessing the marginal abatement cost and long-term scenarios of sink enhancement measures. Concise policy conclusions from the modelling exercise William at supporting the implementation of the Kyoto Protocol commitments as well as post Kyotonegotiations.In the proposal we advocate a spatially explicit approach that is motivated by the fact that LULUCFactivities are by their very nature spatial entities and aggregate non-spatial treatment could, according to our experience, lead to serious biases in the assessment. Furthermore, we propose not only simple and easily tractable static and deterministic approach for cost calculations, but also more comprehensive, dynamic, and uncertainty (risk)-based treatments. We believe that such a multi-dimensional approach is necessary since ecosystems are more complicated and complex in their responses and therefore robustness
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Improving access to digital cultural heritage for multiple users and uses via a disruptive cloud based software as a service' (COMWORK).

assistant: **Concept**

The highest priority for around 17.000 European SMMs in the next few years is to implement a digital age shift in order to find a new and sustainable business model that works within the context of our changing society. Going digital for SMMs, with few paid staff and limited resources, is challenging. A recent survey highlights that most significant barriers to digital development in Museums are slow or limited IT systems and network (52%), lack of time (80%) and lack of resources (66%).CoMwork srl an innovative and social start-up, spin off of TAI: has been created to further proceed with the market readiness of CoMwork's solution, a  game-changing platform for museum collection management that fosters a new business model for the sector. Being 64% lower cost than alternative solutions, Small and medium museums (SMM) will avoid upfront investments for licencing or high annual fees and costs for additional modules. Through the project we expect an increase of around 700.000 new digital content pages available on the web from SMMs by 2020, meaning an increased revenue of target museums of around 20%. In combination, expected revenues for CoMwork are estimated to be around 4,2M€ in 4 years from market launch.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Deciphering the mycobiome of indoor environments by high-throughput sequencing'.

assistant: **Innovation**

Fungi have ubiquitous distribution in natural ecosystems and are also common in the built environment, where people spend major parts of their lifetime. When moisture is present, fungal growth can cause material deterioration and adverse effects on the occupant’s health. Traditional methods for analyzing the indoor mycobiome, such as culturing and microscopy, have severe limitations.In this project we will improve the knowledge about the indoor mycobiome in Northern Europe by combining air sampling with high-throughput DNA sequencing (HTS) and qPCR. We will (i) construct a reference DNA sequence collection for indoor fungi, (ii) analyze the small-scale spatiotemporal variation of the indoor mycobiome within selected buildings, including a complete description of all indoor compartments, and (iii) characterize the geographic variation of the indoor mycobiome on a larger spatial scale (Scandinavia) through an aerobiological study of more than 200 buildings.The project will be conducted at the Oslo Mycology Group (University of Oslo) in close collaboration with the Norwegian consulting firm Mycoteam AS, which possesses 30 years expertise on indoor fungi. The project will improve our basic understanding about the indoor mycobiome, which will help to control fungal outbreaks as well as their adverse effects on building materials and occupants. Results from this study will be a first step towards a streamlined HTS based indoor mycobiome profiling approach with a commercial potential.This intersectoral project involves relevant expertise in fungal biology, building mycology, DNA analyses, and bioinformatics, and will provide a highly professional framework for the Experienced Researcher, as well as an excellent basis for his further development as an independent researcher.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identification of age-related Human Blood factors as a therapeutic target for Alzheimer's disease' (HeBe) under Horizon 2020.

assistant: **Objectives**

One of the most exciting findings in neuroscience has been the discovery of peripheral blood factors with rejuvenating or ageing effects on the mouse brain. These factors were discovered by parabiosis experiments in which the blood circulation of young and old animals is fused. The findings imply that the properties of young blood can rejuvenate the older brain. Ageing is the most important risk factor for Alzheimer’s Disease (AD), but there have been only limited attempts to develop therapies targeting the ageing process. Also, it is not known whether humans have similar blood factors that could be therapeutic targets in AD.The overall aim of the HeBe project is to discover blood factors with a rejuvenating or ageing effect on the human brain that can thus become therapeutic targets for AD and other age-related brain diseases. For ethical reasons, parabiosis experiments are not possible in humans. HeBe will circumvent this problem using a highly original approach in which I will define extreme biological age phenotypes in women and men based on the difference between biological and chronological age. I will use advanced proteomics and metabolomics to identify blood factors that differ between these extreme phenotypes, and then develop a targeted assay toolkit to measure these factors in large longitudinal cohorts of cognitively unimpaired and preclinical AD individuals.The main hypothesis of HeBe is that higher levels of rejuvenating blood factors decrease the rate of neurodegeneration, while higher levels of ageing blood factors increase the rate of neurodegeneration. If this hypothesis is confirmed, I will provide a new therapeutic target for AD. By the end of HeBe, I will also design a proof-of-concept clinical trial to assess whether life-style or pharmacological i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Sustainable growth, employment creation and technological integration in the european knowledge- based economies'.

assistant: **Objectives**

The project is focussed on the impact of technological change, globalisation and tertiarisation on the dynamics of the labour market in Europe. We aim to investigate the interplay between the rise of information and communication technologies (ICTs), the globalisation process and the rise of business services in promoting the technological integration of the EU economy and in affecting employment. In particular we will study the role of regional integration in technology diffusion, growth performance, and employment and how the poor performance of Europe in the new technologies has contributed to the high rates of unemployment. By analysing the relationship between innovation and job creation we aim to offer an effective base for the implementation of policies related to the newly launched Community action. To establish a strong knowledge based economy as a way to improve competitiveness and employment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Self–Alerting Safety Jacket' (SASJACKET).

assistant: **Concept**

The goal of our project is to develop and integrate an appropriate personal alert and locating beacon (PLB) solution within a life-jacket/PFD so that it becomes integral to the purchase, supply and use of PFDs as Personal Protection Equipment (PPE). These ‘self-alerting’ safety jackets (SASJackets) would be used for local alerting and rescue by maritime and inland waterway employees, passengers, and recreational sailors. The proper integration of PLB technology into PFDs will allow users to have the maximum level of protection at all times.  The separation of these safety tools require numerous procedures and manual processes to be adhered to in order to attain a consistent level of safety.There could be wider potential to extend the use of the technologies developed in the project for other health and safety alerting and locating applications, e.g. for lone workers, and for remote operations in difficult environments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Merging an interconnected innovation ecosystem of deep-tech and critical technologies to boost circularity through resilient transformation in the EU' under Horizon Europe.

assistant: **Concept**

MOSAIC will look for the interaction with talented SMEs and start-ups working on critical technologies and deep tech, to help reaching Industry 5.0 while creating an innovation ecosystem. These companies will enrich the value chains in digital and deep-tech innovation, clean technologies, and net-zero technologies. Like this, MOSAIC will create an excellence hub established in different major pillars of deep-tech innovation, where the partners bring and exchange knowledge and technology transfer.Involving local, regional and national stakeholders MOSAIC will call for better coordination at all levels for better synergies between EU funds and programs that aim to stimulate resilient innovation and circularity. Collaborations between the public sector, universities, businesses and society will be acknowledged as critical to innovation and to increase the competitiveness of regions' different development levels to bring solutions tailored to regional and local needs.As a result, MOSAIC will provide a Design Options Paper showing the outcomes of the execution of the ecosystem actions providing guidance to future developments of the innovation ecosystems, including the compilation of conclusions from mapping & integration of MOSAIC stakeholders and regions for the generation of the hub-network, selection of 4 deep-tech and critical technology enterprises based on the potential for the ecosystem and the analysis of the agencies and agents that count on EIC Accelerator certification to apply to the Plug-in scheme.


**Keywords:** SMEs and startups support, innovation mechanisms, mobilisation of policies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced High-Temperature Reactors for Cogeneration of Heat and Electricity R&D' (ARCHER).

assistant: **Concept**

In line with the Sustainable Nuclear Energy Technology Platform (SNETP) Strategic Research Agenda (SRA) and Deployment Strategy (DS), the ARCHER project will extend the state-of-the-art European (V)HTR technology basis with generic technical effort in support of nuclear cogeneration demonstration.The partner consortium consists of representatives of conventional and nuclear industry, utilities, Technical Support Organisations, R&D institutes and universities. They jointly propose generic efforts composed of:-System integration assessment of a nuclear cogeneration unit coupled to industrial processes-Critical safety aspects of the primary and coupled system:oPressure boundary integrityoDustoIn-core hot spotsoWater and air ingress accident evaluation-Essential HTR fuel and fuel back end R&DoPIE for fuel performance code improvement and validationoBack end research focused on radiolysis-Coupling component development:oIntermediate heat exchanger developmentoSteam generator assessment-High temperature material R&D:oCompletion of graphite design curvesoMaking use of the experience of state of the art metal in conventional industry-Nuclear cogeneration knowledge management, training and communicationThe activities proposed are imbedded in the international framework via GIF; direct collaboration within the project with international partners from the US, China, Japan, and the republic of Korea; and cooperation with IAEA and ISTC.The proposal is a technical building block supporting nuclear cogeneration as fossil fuel alternative for industry and as such supports a high potential contribution to European energy strategy as defined in the SET-Plan. The results of the proposal will be reported to SNETP, to support the strategic pillar of ‘other uses of nuclear energy’, and the e