RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'ALK-driven cancers: a Portfolio of ONcoimmunoTherapies to achieve tumor Eradication'.

assistant: **Innovation**

Cancers driven by the oncogenic activation of the ALK gene include subsets of non-small cell lung cancer, lymphoma, neuroblastoma, melanoma, glioblastoma, thyroid cancer, stromal tumors and other hematologic malignancies and solid tumors. Typically, these cancers affect children or young adults in healthy conditions with a long expectancy of life. They are currently treated with ALK tyrosine kinase inhibitors (TKIs) either in first line or at relapse after other standard therapies. ALK TKIs reduce tumor burden dramatically, and often induce a prolonged state of minimal residual disease (MRD) resulting in several years of extended survival. Eventually, most ALK+ tumors become resistant to ALK TKIs by different mechanisms. Relapses occur in >90% of patients that are then left without efficacious therapies and face a dismal prognosis. This common pattern of evolution of ALK+ tumors, characterized by a prolonged state MRD before the fatal relapse, provides a window of opportunity to develop therapies that might be curative should ALK+ persister cells be fully eradicated. In this proposal, we will develop, test and validate a portfolio of ALK-directed T cell immunotherapies to achieve eradication of residual ALK+ cells during the MRD state induced by ALK TKIs. These immunotherapies include potentiated ALK.CAR-T cells for tumors that express ALK on the surface, and ALK.TCR-T cells for tumors that express ALK internally in the cytoplasm. ALK-directed T cell immunotherapies will be tested alone or in novel modalities of combination between them, with ALK vaccines or with other approaches to further potentiate their anti-tumoral efficacy. We will empower these ALK immunotherapies to eradicate MRD based on the ALK genetic alteration that is specific to each tumor. We envision tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Makersite - The Product Intelligence Platform'.

assistant: **Concept**

Makersite helps to solve the Compliance – Cost – Sustainability problem for products and their supply chains in a single integrated platform. It creates “digital twins” of products and automatically connects both internal and external data to it. These include live cost, supplier, regulation & environmental data sources, making the platform the largest product information repository of its kind. The digital twins serve as comprehensive and live models that teams can collaborate around. Product teams can use the data and the applications to quickly explore and improve the performance of different product configurations by leveraging millions of data points. This allows teams to instantly analyze the impacts and risks of any change to the product.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Clinical validation of miniature wearable dialysis machine' (WEAKID) under Horizon 2020.

assistant: **Objectives**

The project aims to validate a miniature wearable dialysis machine in a clinical setting and to prepare the system for CE-marking. Wearable dialysis allows renal patients to dialyze conveniently and continuously at home or at work, independently from a fixed water supply, up to 24 hrs/day. Such a continuous treatment mimics healthy kidneys and is twice as effective as current dialysis techniques, hereby offering health benefits, quality of life (fitness, mobility) while reducing medical costs (less medication, dialysis at home lowers costs). The miniature wearable dialysis system is based on continuous flow peritoneal dialysis with a fluidic access to the abdomen. The peritoneal dialysate is continuously circulated and refreshed by means of a small and wearable sorption unit that removes toxins from the dialysate. The technology has been demonstrated in preclinial research. In order to demonstrate the clinical efficacy and safety of the system an early feasibility first-in- human trial (phase 0) and a pilot crossover trial (phase 1) will be performed in peritoneal dialysis (PD) patients. The phase 0 study will involve a selected group of 12 stable PD patients in a clinical setting for 5 consecutive days. Upon successful functionality and safety analysis of the phase 0 trial, the clinical validation is continued in a crossover study to test the hypotheses that the system (1) improves blood purification, (2) results in adequate ultrafiltration and (3) does not show important safety/ biocompatibility problems. Hereto 30 stable PD patients will be randomised to receive either with the wearable system in the first month and conventional PD in the second month or vice versa. The clinical trials will be performed by three European medical centres specialised in dialysis treatm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Direct and Indirect Searches for New Physics with Diboson Final States at ATLAS' under Seventh Framework.

assistant: **Concept**

The Large Hadron Collider (LHC) at the European Organisation for Nuclear Research (CERN) promises a major step forward in the understanding of the fundamental nature of matter. Four large experiments at the LHC are complementary addressing the question of the origin of our Universe by searching for the so-called New Physics.The ”Standard Model” (SM), the theory that reflects our understanding of elementary particles and their fundamental interactions, has been extensively studied and experimentally verified to an unprecedented precision over the past decades. Despite its impressive success, there are many unanswered questions; which suggest that there is a more fundamental theory which incorporates New Physics. It is expected that at the LHC either New Physics beyond the SM will be discovered or excluded up to a very high energies, thus our view of the fundamental structure of the Universe will be challenged and probably revolutionized in the coming years.The ATLAS  experiment is dedicated to address the key issue of ElectroWeak Symmetry Breaking (EWSB) and linked to this the search for the Higgs boson as well as the search for Physics beyond the Standard Model. The analysis proposed here is measurement and searches for New Physics in diboson processes . The New Physics effects in the diboson sector will be observed either directly, as in the case of new particle production decaying to diboson, e.g., new vector bosonsand extra-dimensions, or indirectly through deviations from the SM predictions of observable such as cross sections and asymmetries. Triple gauge boson self-coupling (TGC) are extremely sensitive to New Physics, thus a very powerful tool for indirect searches for New Physics contributions through loop corrections.At the LHC, the unprecedented center-of-mass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Frontier research in arterial fibre remodelling for vascular disease diagnosis and tissue engineering' under Horizon 2020.

assistant: **Concept**

Each year cardiovascular diseases such as atherosclerosis and aneurysms cause 48% of all deaths in Europe. Arteries may be regarded as fibre-reinforced materials, with the stiffer collagen fibres present in the arterial wall bearing most of the load during pressurisation. Degenerative vascular diseases such as atherosclerosis and aneurysms alter the macroscopic mechanical properties of arterial tissue and therefore change the arterial wall composition and the quality and orientation of the underlying fibrous architecture. Information on the complex fibre architecture of arterial tissues is therefore at the core of understanding the aetiology of vascular diseases. The current proposal aims to use a combination of in vivo Diffusion Tensor Magnetic Resonance Imaging, with parallel in silico modelling, to non-invasively identify differences in the fibre architecture of human carotid arteries which can be directly linked with carotid artery disease and hence used to diagnose vulnerable plaque rupture risk.Knowledge of arterial fibre patterns, and how these fibres alter in response to their mechanical environment, also provides a means of understanding remodelling of tissue engineered vessels. Therefore, in the second phase of this project, this novel imaging framework will be used to determine fibre patterns of decellularised arterial constructs in vitro with a view to directing mesenchymal stem cell growth and differentiation and creating a biologically and mechanically compatible tissue engineered vessel. In silico mechanobiological models will also be used to help identify the optimum loading environment for the vessels to encourage cell repopulation but prevent excessive intimal hyperplasia.This combination of novel in vivo, in vitro and in silico work has the potential
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Management of Municipal Water Waste Treatment Plants Potential by-Products of Sewage Sludge Ash type, as Active or non-Active Additions to Portland Cement-based Binders' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The main objective of the proposal is to design a flow chart for the valorisation process of sewage sludge (SS) waste stream from municipal water treatment plant origin, (code 19 08 05, in accord with 2014/955/EU Decision), and its subsequent use as supplementary cementitious material (SCM).The End-of-Waste (EoW) criteria is applied, in the first stage, by assessing of the potential organic and inorganic hazardous constituents content and manner of their removal or inertization (by optimized incineration process, mainly). Secondly, in order to generate a final SS ash (SSA) by-product of constant physical-chemical properties, apt to be used as a SCM, an adequate analysis of its main chemical components (SiO2, Al2O3, Fe2O3) is provided, according to EN and ASTM requirements and testing to quality standards, with a special consideration of eventual pozzolanic activity. Once the classification of thus obtained SCM is carried out as active or non-active addition, its performance in the Portland cement (PC) based binders is studied. The manufacturing of new PC/SSA cements and its resultant products, concretes and mortars, is focused from the following principle perspectives: mechanical compressive and flexural strength efficiency, volume soundness and chemical durability in front of chemical aggressive media like sulfates, chlorides, sea water action, etc. Finally, an impact assessment of the proposed EoW procedure is evaluated taking into account its legal, economic, market, social and environmental aspects.The current proposal seeks to address regional work programme of sustainable energy development in Central Poland by putting forward an idea of the local residual materials management, once converted into by-products, to manufacture concretes and mortars in the same condi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Approximation of maxwell equations by numerical methods on non-matching grids' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content The aim of the research project is the mathematical analysis and development of accurate numerical algorithms for the tridimensional modelling of non-stationary electromagnetic phenomena in geometries with moving boundaries. The system of time dependent Maxwell equations is approximate by combining time advancing schemes, mesh adaption procedures and the mortar element method, which is an optimal non-conforming finite element approach based on domain decomposition. The decomposition of the problem domain into subdomains is used to model complex geometries and different material properties. Moreover, different grid structures, different refinement levels and different degree of interpolation are considered to describe at best the problem characteristics in each subdomain. The spatial approximation is based upon finite element methods and, in each subdomain, it is carried out independently of the approximation within the adjacent subdomains Consequently, different (non-matching) sets of nodes are generated at the interfaces. The intertace matching constraints (trasmission of either boundary or continuity conditions) are imposed by using an auxilary mortar trace space defined over the union of all the intertaces and an appropriate variational operator. This method should provide a global error which is bounded by the sum of the local errors (optimality) and it allows to easily treat geometries with moving boundaries. Time advancing schemes based on finite differences are applied to solve the system of ordinary differential equations resulting from the spatial approximation Explicit and implicit schemes are analysed in relation to their ability in describing transient phenomena. Reliable and robust error indicators are analysed to extend mesh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'FP7 High Luminosity Large Hadron Collider Design Study' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The Large Hadron Collider (LHC) is the largest scientific instrument ever built. It has been exploring the new energy frontier since 2009, gathering a global user community of 7,000 scientists. It will remain the most powerful accelerator in the world for at least two decades, and its full exploitation is the highest priority in the European Strategy for Particle Physics, adopted by the CERN Council and integrated into the ESFRI Roadmap. To extend its discovery potential, the LHC will need a major upgrade around 2020 to increase its luminosity (rate of collisions) by a factor of 10 beyond its design value. As a highly complex and optimized machine, such an upgrade of the LHC must be carefully studied and requires about 10 years to implement. The novel machine configuration, called High Luminosity LHC (HL-LHC), will rely on a number of key innovative technologies, representing exceptional technological challenges, such as cutting-edge 13 tesla superconducting magnets, very compact and ultra-precise superconducting cavities for beam rotation, and 300-metre-long high-power superconducting links with zero energy dissipation.This FP7 Design Study proposal (HiLumi LHC) is part of an overall project that will federate efforts and R&D of a large community towards the ambitious HL-LHC objectives. HiLumi LHC involves participants from outside the European Research Area (ERA), in particular leading US and Japanese laboratories, which will facilitate the implementation of the construction phase as a global project. The proposed governance model is tailored accordingly and may pave the way for the organization of other global research infrastructures.HiLumi LHC will help to foster opportunities for the European industry to bid for contracts worth 300 M€ in innovative fields during t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cataracts in farmed fish - A multidisciplinary initiative for scientific progress.' in the context of a Fourth Framework call.

assistant: **Objectives**

Cataracts (reversible or irreversible lens opacities) is a production disorder of several species of fish. The aim of this project is to disseminate knowledge on occurrence and causation of cataracts in farmed fish, and to initiate further research to prevent and control the disease.To achieve this goal, we propose to create a multidisciplinary network of European scientists and aquaculture industrialists to overcome present restraints in research. The project will thus contribute to secure the health and well being of farmed fish, and improve the cost effectiveness of European aquaculture. The competitive advantage of European suppliers of materials or services to the international aquaculture market will be increased. Successful control of cataracts is considered even more important in order not to compromise consumer perception of the aquaculture industry as such, particular regarding its ethical standards of production and the quality of its products. These issues are of major importance for the industry's further competitiveness in the international food market. Bringing the aquaculture industry, fish pathologists and nutritionists together with multidisciplinary working ophthalmologists, a new and unique scientific collaboration for the benefit of future aquaculture production, fish welfare and fish health research will be created; in itself a most valuable goal.These main objectives have been detailed as follows:- The project will disseminate scientific knowledge and state-of-the art in cataract research, and discuss current and planned work conducted in this field.- The project will facilitate exchange of study specimen and transfer of research methodology between laboratories.- The project will initiate epidemiological studies and thus provide new scientific da
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'WHeelchair Activity Monitoring project (WHAM)' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Wheelchair users (WCU) are three to five times more inactive than the general population, leading to a high risk of developing preventable secondary conditions. Although physical activity (PA) guidelines have been specifically developed for WCU, we lack systematic approaches to implement them in practice, as well as valid algorithms to monitor PA change in WCU through sensor-based solutions. Accordingly, the overall scientific aim of the WHeelchair Activity Monitoring project (WHAM) is to advance PA research and practice in WCU by developing valid digital markers for monitoring of and providing feedback on PA, paving the way for implementation and intervention. I will accomplish this through combining the complementary research fields of 1) behavioural intervention studies focusing on increasing PA in WCU (core competence University of British Columbia, UBC; outgoing phase) and 2) sensor-based PA monitoring (core competence Norwegian University of Science and Technology, NTNU; returning phase – consolidated by non-academic placement at Maastricht Instruments, which develop research prototypes including PA monitors). WHAM’s scientific aim is achieved through three objectives: 1) Measure the effect of a pragmatic exercise intervention trial on self-reported physical activity levels and cardio-respiratory fitness, 2) Develop valid algorithms for tracking PA markers in WCU, and 3) Co-create a framework that outlines how PA can be conjointly monitored and provided feedback on in WCU. This fellowship will enable me to become established as an internationally recognized researcher in the field of “physical activity and disability”, while bringing together ongoing national disjointed research activities in this field. Altogether, my overall ambition is to contribute to reducing