RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Occupational Health and Safety Economics' in the context of a Seventh Framework call.

assistant: **Objectives**

Occupational health and safety (OSH) of workers is at the heart of the production process. The economic dimension is therefore an important but not clearly defined aspect. The current projects objective is to clarify the economic dimension of OSH. It will bring together researchers and stakeholders and present the results of their discussions in the following three different international workshops. 1. The impact of OSH and OSH-interventions on productivity. It has been argued that OSH can have a big impact on productivity with large potential gains. We will focus on underpinning this statement with evidence and case-studies. In addition, we will improve the calculation of costs and benefits resulting from impact on productivity. 2. Economic evaluation of OSH-interventions. Economic evaluation has been elaborated for health care interventions as cost-effectiveness-analysis. In contrast to cost-benefit analyses in companies, it relies more heavily on evidence of effectiveness. We will combine both approaches, provide better tools for calculations and better integrate evidence of effectiveness. 3. Economic incentives for enhancing the uptake of preventive OSH-interventions. For these incentives, instruments such as taxes, subsidies, penalties or insurance-premiums are used. The workshop will give an overview of instruments and their effectiveness. All workshops will elaborate the topic of interest against the background of the changes in working life in Europe. The results will be reported on a website and in an scientific journal. The current proposal builds on previous work of the EU Agency for Safety and Health at Work and combines it with the latest findings from scientific research on effectiveness and economic evaluation of OSH interventions. In addition, the propos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A metal-assisted bioorganic approach to Hetero Diels-Alder products' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

While our mechanistic understanding of naturally occurring Diels-Alder is still in its infancy, more information on protein-catalysed [4+2] additions has been obtained with catalytic antibodies. Several Diels-Alderase antibodies have been generated from synthetic haptens mimicking more often the highly ordered transition state of Diels-Alder reactions. Surprisingly, only one example of antibody-mediated hetero Diels-Alder (HDA) reaction of carbonyl compounds has been reported despite the enormous synthetic potential of this particular transformation. The proposed work describes the development of a novel highly enantio-selective antibody-route to access hetero Diels-Alder adducts of carbonyl compounds that we expect might be amenable to the preparation of various synthetic intermediates for natural product synthesis. Two mechanistic pathways can operate for Lewis acid-mediated hetero Diels-Alder reactions of carbodienes with carbonyl compounds.These two pathways are formulated as a pericyclic cycloaddition by analogy with the catalysed all-carbon Diels-Alder reaction or the formation of a Mukaiyama-aldol intermediate followed by an intra-molecular Michael-type addition. To a great extent, these are a function of the catalyst and solvent system along with the structural features in the reactants. Specifically, we hypothesized that the commercially available aldolase class I antibody 84G3 is a potential catalyst for the preparation of HDA adducts of carbonyl compounds according to a stepwise pathway where an aldol condensation might serve to join the reactants and a ring closure on the ß-carbon of the hydroxyen one would complete the cyclocondensation. The originality of our approach relies on the combined use of biocatalysis and metal (palladium) catalysis to address res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Operator Algebras, Free Probability, and Groups' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Starting with Voiculescu's pioneering work on free probability from 1983, there has for more than 25 years been a strong development in mathematical research on the interrelations between operator algebra theory, probability theory and group theory. The PI has over the last 10 years made several important contributions to this development. The aim of the project is to target some of the main open problems in this area, such as the isomorphism problem for free group factors and Connes' embedding problem for finite factors. The project will take place at University of Copenhagen in close contact with its well established group in operator algebras.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Geometry and stability of singularities in integrable systems' (GEASSIS).

assistant: **Innovation**

This project is mainly concerned with the geometry underlying integrable dynamical systems both Hamiltonian and non-hamiltonian. The best well-known examples of integrable systems are probably completely integrable Hamiltonian systems. Hamiltonian systems arise naturally in mechanical systems. For instance the motion of celestial bodies or Shrondinger equation are examples of these phenomena. Non-Hamiltonian systems arise in dynamical systems with non-holonomic constraints. Completely integrable Hamiltonian systems have their origin in Classical Mechanics but are currently present in many other disciplines like for example Algebraic Geometry (toric manifolds and mirror symmetry). A completely integrable system on a symplectic manifold is given by a moment map. Under some mild conditions, the theorem of Arnold-Liouville asserts that the regular level sets of the moment map are tori and the system on them is quasi periodic. Unfortunately this theorem does not take singularities into account.The main goal of t his proposal is to study local and semi-local geometrical properties of integrable dynamical systems and, in particular, their normal forms in a neighbourhood of a singularity. The following objects are associated to an integrable dynamical system: a foliation, a geometrical structure on the manifold (symplectic, contact, Poisson...) and in the holonomic case also an additional geometrical structure attached to the leaves of the foliation (Lagrangian, Legendrian or isotropic). This proposal attempts to stud y normal forms a la Weinstein for general dynamical systems in symplectic, Poisson, contact and Dirac manifolds taking into account singularities. We are also interested in obtaining the equivariant version of these normal forms results. We also want to study thos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Self-Centring Earthquake-Resilient Hybrid Steel-Concrete Shear Walls with Rocking Beams' (SC-HYBWalls) under Horizon 2020.

assistant: **Objectives**

Control of both structural and non-structural damage is of utmost importance in Performance-Based Earthquake Engineering. Alleviation of the structural damage and reducing collapse risk under sever ground motions has been a general research focus in earthquake engineering. However, earthquake reconnaissance reports also foreground the significance of injuries, fatalities and economical losses due to failure of non-structural components. Furthermore, the functionality of some critical buildings carrying acceleration-sensitive equipment such as hospitals can be interrupted due to non-structural damage after a seismic event. Therefore, it is vital to urgently meet an inevitable social demand for truly resilient construction. In target resilient buildings, both structural and non-structural damage should be minimized simultaneously in order to mitigate direct and indirect losses such as repair costs and costly downtime during which the building cannot be used or occupied. Different strategies have been implemented by researchers to mitigate the structural and non-structural damage. As an instance, self-centering frames have been developed with the aim of avoiding residual drifts after a seismic event. Meanwhile, hybrid steel-concrete frames consisting of coupled walls with controlled energy dissipation mechanism have recently grabbed a lot of attentions since they take the advantage of both stiffness of RC walls and the ductility and energy dissipation capacity of steel components. The aim of this project is to develop and investigate a novel resilient structural system in which a self-centering mechanism is coupled with hybrid steel-concrete structural systems. Hence, the new system will be capable of resisting moderate to high intensity ground motions while both structura
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of aluminium components locally reinforced with composite inserts' in the context of a Fourth Framework call.

assistant: **Objectives**

European commercial industries need the development of lighter components with improved characteristics and easy recyclability for the next future, in order to develop more efficient products with reduced pollutant emmisions, at low cost. In this way, the industrial aim of the present project is to obtain low cost components with improved properties in the needed areas. In order to reach this goal, a suitable production process for the manufacturing of aluminium based components locally reinforced with inserts, in the zones where an improvement of some properties is required, will be developed. Different type of inserts (of various shapes and characteristics) will be used for this purpose. Among them, it is intended to use inserts made of commerdal discontinuous metal matrix composites (MMCs) formed by gravity casting, and porous prefomms made of low cost discontinuous reinforcements such as alumina short fibers, graphite particles or others. Some high productivity techniques have been previously selected: Low-pressure casting, Pressure diecasting and Gravity casting, which are traditionally and widely used for the manufacturing of several industrial components in commercial sectors, specially in the automotive one. The use of local reinforcements with the techniques selected will allow to manufacture components with improved properties in the required areas, at a low price in comparison with the same components fuily made of MMC. Moreover, the cost due to the machining will be markedly reduced since only localized small areas will be reinforced with inserts. These areas show better mechanical properties at high temperatures, and specially better wear behaviour, among other interesting advantages. The technology considered could also open up an important market of appli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'INnovatiVE cohereNt detecTIon Optical access Networks', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In the called “information age”, digital communications play an essential role on the economy and sustainable growth of the society.  Access networks are essential part of the communication infrastructure as bridge between end-users and core networks. Their design must make possible the provision of real-time high-bandwidth access to Internet, essential for advanced communication services as immersive video and ubiquitous cloud computing. It is clearly foreseen that the only long-term solution to the problem involves optical fiber as transmission medium, the so called optical access networks. Passive optical network (PON) is the most widely employed technology because of the cost reduction it entails, but the capacity of actual time-division multiplexed PONs will be exhausted eventually as more bandwidth-hungry applications become available in the near future. Telecommunications carriers face the challenge of meeting the unprecedented bandwidth demand by end users at the same time the capital and operating expenditures requirements are reduced.INVENTION project targets the development of cost-effective and high capacity communication architectures for their employment on optical access/metro networks. The proposed concept will be based on the employment of coherent detection with low-cost and simplified optical receiver architectures, making sure that the proposed approaches meet the cost requirements of these optical networks. The proposed concepts will be implemented by a suitable combination of optical signal processing techniques and digital-signal-processing (DSP) algorithms, keeping the required DSP at realizable levels. The final scope of INVENTION is the proposal of mid-term and long-term solutions for the achievement of the objectives included in the digital ag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Computational design of synthetic antibody repertoires for accelerated therapeutic discovery'.

assistant: **Innovation**

Synthetic human antibody repertoires are an important source of therapeutics; however, antibodies often exhibit undesirable developability liabilities, such as low stability, solubility, and polyreactivity, that limit their potential as drug candidates. CADABRE will design next-generation repertoires comprising billions of diverse human antibodies that exhibit excellent developability properties, with the following aims:1. Repertoire design: We will use our newly developed combinatorial Rosetta atomistic design paradigm to select human germline genes and design H3 multipoint mutants. These will combine into billions of diverse, low-energy, and foldable full-length antibody variable domains for expression in a phage-displayed repertoire. The repertoires will comprise hundreds of possible germline gene combinations, increasing the structural diversity relative to existing repertoires and the odds of obtaining diverse antibodies toward any antigen.2. Learning developability principles: High-throughput screening will identify heat-stable antibodies that are not polyreactive. Data from deep sequencing will be used to train an AI-based predictor of these properties that will be used to improve the repertoire and rank antibody candidates. We will iterate repertoire design, screening, and learning until we converge on a repertoire that exhibits excellent properties.3. Verifying relevance to therapeutic discovery: We will select antibodies that target antigens that represent relevant drug targets, verifying that the antibodies exhibit high stability, affinity, and developability.CADABRE combines the strengths of our protein-design methods (generating stable antibodies) and phage-display screening (unbiased binder selection). It will deepen our understanding of the biophysical un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Modulating and Profiling Receptor Tyrosine Kinase S-palmitoylation in Breast Cancer' (RTKPalm).

assistant: **Innovation**

Breast cancer is one of the most diagnosed cancers and the leading cause of cancer death in women worldwide. Breast cancer cells need activated receptor tyrosine kinases (RTKs) to invade, proliferate, and metastasize. Increased activity and overexpression of RTKs is associated with poor prognosis for breast cancer patients. Therefore, multiple RTKs have emerged as attractive therapeutic targets. However, resistance to therapies is a persistent problem for the development of therapeutics targeting RTKs. New and innovative approaches to effectively target these receptors are required. Recently S-palmitoylation has been identified as an important post-translational modification that regulates signal transduction, protein trafficking and degradation of specific RTKs in breast cancer. The substrate scope, role, extent of dysregulation and the enzymes responsible for the S-palmitoylation of specific substrates in breast cancer is largely unknown. In this context, the aim of the proposed project is to implement novel chemical biological tools and methods, to gain insight in the extent, regulation and role of S-palmitoylation of RTKs in breast cancer. This insight will facilitate the identification of new approaches to therapeutically target RTKs in breast cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DIVERLESS SUBSEA PRDUCTION SYSTEM TEMPLATE SYSTEM TESTING PROGRAMME [STAGE 3] : INSHORE TESTING' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Development of any offshore hydrocarbon reserves discovered in water depths in excess of 350m on the European Continental Shelf is considered to be of crucial importance to Europe. In order to sustain exploration in such areas with the objective of increasing European recoverable reserves it is essential that cost effective diverless subsea production technology is developed.BP Petroleum Development Ltd's Diverless Subsea Production Systems ( DISPS) Project has the objective of providing diverless technology for natural drive oil or gas production, oil production with gas lift or water injection duty by the mid 100's when development of deeper water reservoirs will be necessary to maintain European reserves of hydrocarbons.Evaluation of results is in progress.The project is a staged one following on from Stages 1 and 2 being undertaken under Contract TH/03233/87. Stage 3 consists of a series of tests at an inshore sheltered location using the Test Rig manufactured under Stage 1. Stage 4 will consist of testing at an offshore location. These tests are aiming to demonstrate in progressively mogre onerous operating conditions that the components and systems, envisaged by the BP DIOSPS development programme for a multiwell modular template, will work.The BP DISPS development programme is developing the principles, concepts, designs, techniques and equipment to exploit hydrocarbon reserves in 350m-750m water depths utilising subsea diverless techniques. The principal system under development is a multiwell ( 2-18 slot) modular template able to be installed and maintained without the use of divers. The template is capable of catering for a manifolded or non manifolded arrangement with satellite wells tied in, and produced through either a remote or local, fixed or floating pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'TECHNOLOGY ASSESSMENT IN TELE-NEURO-MEDICINE' in the context of a Fourth Framework call.

assistant: **Objectives**

TASTE is an accompanying measure to assist assessment of tele-neuro-medicine (TNM) services, with Telematics Programme projects in TNM a first target. The initiative will produce guidelines for TNM applications deployment and the professional assessment of TNM services, and a methodology to assess the impact of technology in TNM image transmission networks in terms of patient care and comfort. TASTE workshops, participation in an international congress and a technical letter will be among means used to publicise the project, which will benefit healthcare providers and enable better targeted industrial development in the field.