RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Detection of visual motion in the cortex' to be submitted under Horizon 2020.

assistant: **Abstract**

Direction selectivity is a feature of selected neurons in the visual cortex that is conserved in evolution. The emergence of cortical direction selectivity has been extensively studied but its circuit mechanism is still debated. My goal is to understand the circuit mechanism of cortical direction selectivity that is independent of retinal direction selectivity. I plan to approach this by using two animal models in which retinal direction selectivity has been disrupted. I will investigate the neuronal circuits of those cortical direction-selective neurons which retain their specificity in these animal models by performing single-cell-initiated functionalized rabies tracing and single-cell electrophysiological recordings. I will ask the three following questions: Do axon terminals of the principal cells of the lateral geniculate nucleus (LGN) fully lose direction selectivity after the abolishment of retinal direction selectivity, or could cortical feedback from layer 6 entrain direction selectivity in a subset of LGN cell axon terminals? What is the synaptic input profile underlying retina-independent cortical direction selectivity in pyramidal neurons? What is the contribution of the local presynaptic networks to the direction-selective tuning of pyramidal neurons with retina-independent cortical direction selectivity? This work will provide insights into how cortical selectively for environmental features arises.


**Keywords:** Visual system ,  Cortex ,  Feature selectivity ,  Network tracing ,  Genetic manipulation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Efficient numerical methods for deformable porous media. Application to carbon dioxide storage.' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Continuum mechanics represents one of the most important research fields in applied sciences and engineering. Numerical simulation is increasingly prominent in this field, which forms the natural ground for application of very recent techniques of numerical analysis and scientific computing. In the last decades, the simulation of multiphysics problems, where different models interact to describe a complex phenomenon, has received a lot of interest. The current project is framed in this spirit, with the double aim of advancing in the numerical simulation techniques as well as in the improved understanding of the physics in the application field. As main line of work, we treat mathematical and practical aspects of models for nonlinear poroelasticity, with an emphasis on stable numerical discretizations and the use of fast solvers for the highly efficient solution of the resulting algebraic systems.  Regarding the practical aspects, we focus on the simulation of the deformation of reservoirs during the carbon dioxide injection stage. In this innovative proposal, we also develop efficient methods for uncertainty quantification in order to assess the risks involved in such process and to evaluate the impact on the environment. The cooperation between Professors Francisco Gaspar and Cornelis Oosterlee goes back 20 years, when they met (as young and fresh) researchers in FhG SCAI in Germany, and cooperated very successfully on multigrid methods. Then, both researchers went their own way (one in Spain, the other in the Netherlands). Now, both being almost 50 years of age, it is important to cooperate closely again, at Oosterlee’s host institution in the Netherlands. Prof. Gaspar is willing to come over to Amsterdam for two years, to boost the research and open new research dire
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MultimodAl analysis/synthesis systEm for human INTERaction to virtual and augmented environments' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The project will define new models and will implement advanced tools for audio-video analysis, synthesis and representation in order to provide essential technologies for the implementation of large-scale virtual and augmented environments. The metaphor, which will inspire the project approach, is oriented to make man-machine interaction as natural as possible, based on everyday human communication means like speech, facial expressions and body gestures from both sides. A case study application on Internet will be developed and demonstrated.Objectives:The objective of the project is to define new models and implement advanced tools for audio-video analysis, synthesis and representation in order to provide essential technologies for the implementation of large-scale virtual and augmented environments. The work is oriented to make man-machine interaction as natural as possible, based on everyday human communication by speech, facial expressions and body gestures. Man to machine action will be based on coherent analysis of audio-video channels to perform low-level tasks, or high level interpretation and data fusion, speech emotion understanding or facial expression classification. Machine-to-man action, on the other hand, will be based on human-like audio-video feedback simulating a person in the machine". A common sw platform will be developed by the project for the creation of Internet-based applications. A case study application will be developed, demonstrated and evaluated.Work description:The project activity will last three years, the first part devoted to specifications definition and tools development, the last part dedicated to the implementation of demo applications. Project coordination, within WP1, will be carried out in synergy and concentration with other pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Spatial & Personal Adaptive Communication Environment: Behaviors & Objects & Operations & Knowledge' (SpaceBook).

assistant: **Innovation**

The SpaceBook project will prototype a speech-driven, hands-free, eyes-free device for pedestrian navigation and exploration. SpaceBook will be developed as open source and progress will be bench marked through controlled task-based experiments with real users in central Edinburgh. The SpaceBook project will generate concrete technical and scientific advances for eyes-free, hands-free navigation and exploration systems which will support applications in tourism, elderly care and tools for urban workers.<br/>In addition to advances in navigation and exploration systems, SpaceBook provides a task environment in which more fundamental scientific and technical knowledge will be generated. Specifically we seek to advance the state of the art in model-based approaches to plan generation and recognition, statistical learning techniques for interaction management and machine learning of semantic analysis components.<br/>The interdisciplinary SpaceBook team brings a wealth of complementary expertise necessary to realize the SpaceBoook vision. Umeå University (Sweden), the project's overall coordinator, brings expertise in natural language interfaces to database systems and spatial databases. The University of Edinburgh (UK) brings expertise in location-based services, dynamic 3D modelling, geographical information systems, system evaluation methodology, discourse processing, and information access and delivery (including question answering). Heriot Watt University (UK) brings experience in machine learning, spoken dialogue systems, data-collection, and evaluation of interactive systems.  KTH (Sweden) brings expertise in dialogue management and the design and development of spoken dialogue systems. Our industrial partner, Liquid Media (Sweden), brings software engineering and com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mammalian Origin of replication – Genome-wide Mapping and Regulation' in the context of a Seventh Framework call.

assistant: **Objectives**

Very little is known about the global organization and regulation of the replication program. Recent advances in genomic methods allow the genome-wide description of the time of replication in mammals. Nevertheless, the spatial information about replication initiations (origin of replication) is still sparse. Such information is crucial for studying mechanistic aspects of replication regulation since the time of replication is determined mainly by the time each origin is activated. In Originome I propose to develop novel genome-wide approaches that will allow origin mapping both in the cell population and the single cell levels. Applying these methods to multiple tissues, growth conditions and organisms, will put me in an excellent position for studying the regulation of the replication machinery. I am planning to combine bioinformatics, comparative genomics and reverse genetics tools to decipher the cis-acting elements that participate in the regulation of the replication program. Successful mapping of origins and characterization of their mode of regulation have broad implications not only in the field of DNA replication. First, replication stress is one of the initial causes of cancer. Therefore, I am planning to decipher the changes in the replication program that occur in response to stress in order to better understand the transformation process. Second, better understanding of replication regulation will allow studying systematically the association between time of replication, transcription and chromatin structure. Taken together, by moving the field of DNA replication from a descriptive into a mechanistic stage, Originome will set the stage for a variety of experimental approaches for  deciphering replication organization and its effects on transcription, chrom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Musicality in Animal Songs'.

assistant: **Concept**

Musicality can be defined as the biological and cognitive abilities necessary to appreciate and create music, which makes song production a significant marker of the trait in the human species. In analogy, some acoustic behaviours of other species, whether birds, whales or primates, have also been traditionally termed songs. However, to date the relatively few studies of parallels between human and animal songs have focused mainly on bird songs. Broader cross-species comparison of animal songs would contribute to addressing the evolutionary origins of music, by disentangling the role of phylogeny and behavioural traits hypothesised to underlie musicality in humans.Two exemplary mammalian singers are humpback whales and gibbons. Their tonal and patterned vocal sequences are traditionally termed songs, but features of musicality have not yet been rigorously assessed. Such an observation would provide critical insights, as these two species possess proposed fundamental traits of musicality (they both have harmonically rich vocalisations, humpback whales are vocal learners and gibbons sing in duets), and they lie at very distinct branches of the mammalian phylogenetic tree. This research will thus test the existence of musical features in humpback whale and gibbon songs.Tests for the presence of overtone-based pitch selection (i.e. frequency intervals corresponding to small-integer proportions drawn from the harmonic series) and expressiveness (i.e. the oscillation between repetition and variation found in human music) have been successful in bird songs. Systematic measurements for these two features will be conducted in passive acoustic recordings of wild singing humpback whales and gibbons, for their songs to be compared with human music. This search will benefit from mac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Next-generation biopharmaceutical downstream process' (2014-2020).

assistant: **Concept**

The scope of the project is the optimization of downstream process (DSP) for the production of Biopharmaceuticals. Biopharmaceuticals have been successfully used as efficient therapeutic drugs for many pathophysiological conditions since the first recombinant product, insulin, was approved in 1982. Despite its efficacy, accessibility is still limited due to extremely high costs. In the production chain, capturing and purifying still represents a major bottleneck. Consequently, improvements in this area produce substantial cost reductions and expand patients’ accessibility to highly efficient drugs. Another aim of this action is to cope with the changing manufacturing demands, by lowering its environmental footprint and moving to more sustainable technologies. This proposal’s main objective is to implement a fully integrated manufacturing platform based on continuous chromatography in combination with disposable techniques for all unit operations of the DSP sequence for biosimilar monoclonal antibodies and derivatives thereof. The action encompasses the entire DSP sequence. We will implement alternative technologies for primary separation, such as flocculation or tangential flow filtration. The expected outcome is a reduction in the size and number of downstream unit operations and the elimination of centrifugation. Alternative approaches to the batch process for the capture step, such as continuous chromatography, will be evaluated in order to improve the efficiency and lower the need for expensive resin volume. Additionally precipitation utilization will be evaluated as an approach to replace protein A chromatography as capture step. A disposable continuous chromatography system will be developed together with novel analytical tools and sensors. Since single-use dispos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'CONCERTO communities towards optimal thermal and electrical efficiency of buildings and districts, based on MICROGRIDS'.

assistant: **Innovation**

PIME’s is a CONCERTO joint proposal from Salburua community in Vitoria (ES), Dale community in Sandnes (NO) and Szentendre community in Szentendre (HU). The three communities will work together on RTD, demonstration and dissemination in order to maximise the effect of the measures implanted and the impact of the individual projects. The project has 14 partners from 4 countries. The proposal unites around some central principles, being the implementation of large scale solar thermal and associated heat storage, the application of intelligent energy management through microgrids and the development of new ESCO models by increase ownership of the inhabitants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Physical human-robot Interaction: dependability and safety' (PHRIENDS), addressing dissemination and exploitation.

assistant: **Impact**

Robots designed to share an environment with humans must fulfil different requirements from those typically met in conventional industrial robots. While the stress in performance is shifted from sheer accuracy to more complex measures, the paramount concern becomes safety of the robot system. A robot may not injure a human being...", or, to rephrase the famous quote, under no circumstances should a robot cause harm to people in its surroundings, directly nor indirectly, in regular operation nor in failures.PHRIENDS is about developing key components of the next generation of robots, including industrial robots and assist devices, designed to share the environment and to physically interact with people. Such machines have to meet the strictest safety standards, yet also to deliver useful performance: this poses new challenges to the design of all components of the robot, including mechanics, control, planning algorithms and supervision systems. We propose an integrated approach to the co-design of robots for safe physical interaction with humans, which revolutionizes the classical design paradigm of industrial robots - rigid design for accuracy, active control for safety - into a new one: design robots that are intrinsically safe, and control them to deliver performance.Although the scope of this STREP proposal cannot encompass the integration of complete robot systems, PHRIENDS will create and deliver new actuator concepts and prototypes, new dependable algorithms for supervision and planning, new control algorithms for handling safe human-robot physical interaction and for fault-tolerant behaviour, and will integrate these components in meaningful subsystems for quantitative evaluation and experimental testing. The project will also importantly contribute to the ongoin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The plague of central asia - an epidemiological study focusing on space-time dynamics', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Plague and other vector born diseases is a large communal and economic problem of the world. The project focuses on the plague of Central Asia as a model system. Extensive statistics is available throughout Kazakhstan and neighbouring countries from the latter part of the 1940s to the early 90s. Seasonal data exist for the host (rodents) and the vector (fleas); and the rate of infestation of the components of the system. Detailed data exists for 1975-98. A substantial amount of the data is computerized; the rest will be as an integrated part of the project. These data represent an ideal basis for the understanding and development of prognostic models for the Central Asia plague system and in a more general context; the obtained results will be of profound value to the health condition in the countries exposed to plagues; in addition, they will provide a unique model system for similar epidemiological systems throughout the world.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Protecting mental health in times of change' (MENTBEST), addressing dissemination and exploitation.

assistant: **Impact**

Europe is in a time of dramatic change, war, economic crisis, climate change, migration, digitalisation, pandemics, ageing and demographic change, place increasing stress and pressure on our societies to adapt to fast-changing situations. Particular vulnerable groups in the general population are especially at risk of being disadvantaged by dramatic societal change, of experiencing particular stressors, and of suffering (further) negative impacts on their wellbeing, including mental health.Members of MENTBEST have researched, created and delivered community-based interventions to reduce depression and suicidal behaviour. These interventions have been implemented and proven effective in 120 communities across 17 EU countries. Building on this experience and intervention framework (EAAD 4-Level-Intervention), the MENTBEST consortium will (a) characterise the scale of the change-related mental health challenges; (b) work with patients, healthcare and other stakeholders to identify interventions and tools that can best build resilience and maintain mental health; (c) combine these interventions with an adapted and broadened EAAD 4 Level Intervention into a comprehensive community-based intervention (COMBINA) (d) deliver and validate COMBINA in five model regions, across five countries, with particular analysis of the benefits for vulnerable groups. An innovative addition will be the RCT of app-based self-monitoring and self-management technologies for mental health, which use AI and n=1 longitudinal statistics to create individualised predictive models and provide users preventive and self-management support.After validation and process evaluation, enhanced COMBINA will be a ready-to-use package which can be adopted throughout Europe and beyond. MENTBEST will inform a compr