RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New laser fluorenscence methods for the study of protein/lipid interactions' under Fourth Framework.

assistant: **Concept**

Research objectives and content The functional role that lipid-peptide interactions play in a wide range of biological processes is acquiring growing experimental support. Nevertheless, detailed knowledge of the basic molecular mechanisms underlying these interactions is lacking. The study of model systems consisting of peptides interacting with lipid bilayers is proving a valuable contribution to a better understanding of these mechanisms. The goal of the present Project is to investigate the molecular details of lipid-peptide interaction, especially with respect to membrane insertion. The peptides selected are the a-melanotropin hormone, essential in regulating skin pigmentation, and two analogues, possessing more potent biological activity. The affinity of these peptides for lipid vesicles containing different types of phospholipids and cholesterol will be investigated in a comparative way using fluorescence spectroscopy and infrared absorption by Fourier transform. A correlation between the different activity of the peptides and the mode of the interaction with the membrane will be proposed. The particular methodologies regarding fluorescence will be quantum yields, lifetimes, steady-state and time-resolved fluorescence anisotropy measurements and, especially, resonance energy transfer, using the single tryptophan of the peptides as energy donor and the new fluorescent octadecapentaenoic acid t-COPA as acceptor. Since the advantageous properties of this new probe, one of the aim of the Project is to develop a detailed operational method for the use of t-COPA in the research of peptide(protein)-lipid interaction. Training content (objective, benefit and expected impact) This project offers a large number of training opportunities for the applicant. On the conceptual
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Satellite-based Information System on Coastal Areas and Lakes', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The objective of SISCAL is to create a software processor providing Near-Real-Time data products derived from satellite data and ancillary GIS-based information. During the development phase of this project, the focus will be on water-related products for end users monitoring coastal areas or lakes. The data products shall be tailored to individual needs of each end user so that the latter does not require specialised in-house knowledge on remote sensing or image processing. This way, SISCAL aims at closing the gap between satellite data providers and end users. Data transport will entirely take place over the internet, both download of satellite data from the receiving stations as well as dissemination of the finalised data products to end users. An user-friendly interface will allow the end user to interactively explore and display data products on the internet. Commercialisation prospects of the processor will be analysed, and a business model be prepared.Work description:In order to achieve the objectives of the proposed project, work is required in the following domains:- Identification and specification of the end user needs within the consortium for Near-Real-Time (<12h after satellite overpass) water-related data products accessible to Earth Observation techniqueso Selection of the most appropriate instruments, evaluation algorithms and ancillary data bases for the identified data products;- Development of a converter transforming the data formats of the different satellite instruments into the format used by the data processor;- Development of automated data retrieval scheme from satellite receiving stations;- Development of the Near-Real-Time data processing scheme for the specified data products;- Development of the GIS processor adding ancillary digital info
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The contribution of multi-stakeholder partnerships to sustainable landscape management' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

There is ongoing political and scientific debate about how to achieve sustainable management of natural resources that will benefit rural communities’ economic development while protecting and enhancing natural assets. Non-governmental multi-stakeholder groups are an important link between policies and on-ground management. There is limited knowledge on the groups’ contribution to sustainable development and only scattered information on how efficiently the activities of these groups can be influenced by means of political programmes such as LEADER. The objective of the project is to identify, analyse and assess the contribution of multi-stakeholder partnerships to the sustainable management of rural landscapes and to the well-being of communities in three European countries. The analysis will classify different types of groups and their specific area of involvement and contribution. The contribution will be assessed from the economic, the social/cultural and the environmental perspective. A crucial point is the definition of the objective(s) that the assessment is made towards. The project aims to consider externally defined objectives (from the regional or national level) as well as internally defined objectives (from within the group or community) and compare the resulting assessments. In addition, the project aims to answer the question which factors determine the resilience and longevity of groups, and whether externally induced groups are as viable as groups that have formed from the bottom up through local stakeholders’ initiative. The project will apply a mix of explorative, qualitative and quantitative methods drawing on institutional analysis, actor network and conflict analysis, as well as communication and behavioural theory. The applicability of the theory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Quantum Many-Body Dynamics and Noisy Intermediate-Scale Quantum Computers: Interconnections, Near-Term Applications, and Novel Simulation Schemes'.

assistant: **Concept**

Simulating the dynamics of quantum many-body systems is notoriously difficult as the computational requirements grow dramatically with increasing system size. While fully-fledged quantum computing may provide a means to handle this challenge, today's noisy intermediate-scale quantum (NISQ) devices are prone to errors and decoherence. This interdisciplinary project promises significant progress in the understanding of nonequilibrium quantum systems and in leveraging the capabilities of NISQ devices for this purpose. The innovative research is going to capitalize on the concept of quantum typicality to explore near-term applications of random quantum states on NISQ devices and to study the emergence of hydrodynamics in isolated quantum systems. By combining state-of-the-art theoretical and numerical approaches with simulations on available quantum hardware, important insights will furthermore be gained into the universal properties of quantum dynamics in driven-dissipative systems, in monitored circuits consisting of unitary gates and projective measurements, and in many-body localized systems coupled to a thermal bath. Tackling these key areas will provide a deeper understanding of fundamental physics and will unravel the inevitable interaction of NISQ devices with their environment. Results may open up new avenues for robust and scalable simulations on NISQ devices, which is vital as quantum technology continues to mature. Additionally, this project will deliver novel NISQ-inspired classical simulation schemes, which are memory-efficient and will pave the way to answer open questions that are challenging for other methods. Highlighting the strong synergy and profound interplay between quantum many-body dynamics and NISQ devices, this project follows Horizon Europe's str
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'FOstering Nitrogen Deposition Assessment over Portugal' (FONDA).

assistant: **Concept**

The Portuguese ecThe Portuguese ecosystems belong to the most nitrogen (N) sensitive in the world and are being threatened by N deposition. Current assessments indicate that the scenario’s compliant to the National Emissions Ceiling (NEC) Directive show that this situation is not about to change even with the significant emission reductions planned until 2030 in Europe. Hence, the Portuguese ecosystems remain at risk, but current research and policy support capacity are lacking. FONDA twinning proposal aims to further develop the expertise of University of Aveiro (UAVR, Portugal) in the field of modelling & mapping the emissions, transport, transformation and deposition of reactive nitrogen (Nr) compounds, through a strategic research partnership with TNO (the Netherlands) and the Free University of Berlin (FUB, Germany) - moving towards a highly productive scientific research group. Understanding the budget of N species is of great importance to better understand the interactions/feedbacks between atmospheric chemistry, biodiversity and climate change. The two internationally leading groups are complementary in their orientation towards fundamental science and education (FUB) and applied science and policy support (TNO). Together, they are responsible for the N deposition mapping for Germany and the innovation therein. The key role of UAVR will be to coordinate this consortium of excellence in the air quality modelling field, while developing and increasing its knowledge, expertise and reputation on N science. Besides the strength of UAVR excellence in the field of air quality by building a national capacity and infrastructure to independently quantify nation-wide N deposition; FONDA aims to train a new generation of highly skilled researchers by offering innovative ed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Incremental Sound Change in Oslo (ISC-Oslo)' (ISC-Oslo) under Horizon 2020.

assistant: **Objectives**

The project ""Incremental Sound Change in Oslo"" (ISC-Oslo) will investigate the socio-demographic origins of five ongoing phonetic changes in a post-hoc phonetic analysis of two corpora from the early 2000s. Working-class children and youth have been identified as one of the main sources of language change. Their lexical, syntactic or phonetic innovations are often disregarded by non-linguists as slang, but it has been shown that these innovations can lead to change within pre-existing dialects and even new social dialects. Due to the fact that these innovations often at first escape social monitoring, this process is referred to by Labov as ""changes from below"" and has been identified in a number of urban studies.The most common – yet, elusive – changes from below are phonetic. These types of changes accumulate generation after generation and result in the evolution of new dialects and languages. What is poorly understood, however, is the role of multiethnolects in this process. These are new varieties formed by the ethnically diverse speakers in Europe’s urban neighborhoods. Like many European cities, Oslo is witnessing the emergence of a new working-class sociolect spoken by the second and third generation descendants of non-western labor and refugee migrants.Multiethnolects have typically been examined within the lens of youth argot or second-language acquisition. ISC-Oslo, however, takes a different point of departure. It seeks to apply Labov’s theory on speakers of multiethnolects, who often have the same socioeconomic profiles as the innovators describes in his studies. The main focus of ISC-Oslo will be twofold. First it would develop an automatic phonetic aligner to phonetically annotate two large corpora collected in the early 2000s. Second, it would analyz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Molecular mechanisms, functions and applications of  RNA-guided DNA transposons' to be submitted under Horizon Europe.

assistant: **Abstract**

Genome engineering has transformed life science research and enabled revolutionary applications in biotechnology and medicine. Despite recent advances brought by the development of CRISPR-associated genome editing nucleases, a universal strategy for efficient site-specific gene editing and insertion in a range of organisms or cell types is currently unavailable. Transposons are natural genome remodelers and gene delivery vectors that modify and transfer genetic information across the tree of life by moving within and between their host genomes. To this end, they encode a vast and diverse reservoir of nucleic acid-targeting and -processing enzymes, whose molecular mechanisms are yet mostly unexplored. Building on our recent structural and biochemical studies, the goal of this project is to advance our mechanistic knowledge of RNA-guided DNA transposons in order to understand their biology and guide their repurposing as next-generation genetic tools. Specifically, the proposed studies will investigate (i) the mechanisms  of RNA-directed DNA mobilization of CRISPR-associated transposons (CASTs), aiming not only to provide insights into their molecular function but also to inform their technological development, (ii) the molecular activities and architectures of TnpB-like transposon proteins, recently identified putative RNA-guided endonucleases of prokaryotic and eukaryotic origin, with the ultimate goal of supporting their application as ultra-compact, broadly applicable genome editors, and (iii) the translation of designer CASTs into a novel programmable DNA insertion technology for precision genomic profiling and engineering. Altogether, the proposed studies will not only make key contributions to the molecular understanding and harnessing of RNA-guided transposons in n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigating the Manipulation of Alignment/Activity via Geometrical INteraction Effects in Liquid Crystals' (2021-2027).

assistant: **Concept**

Controlling the orientation of rod-like objects is crucial for liquid crystal technologies and the natural world. For biological systems, recent studies have shown that living materials form liquid crystalline structures that dictate biological function. These systems are out-of-equilibrium, converting energy into motion, and are modelled as active liquid crystals. However, alignment techniques commonly used in liquid crystal technologies are yet to be leveraged for active counterparts. The prevailing chemical alignment methods do not scale to these larger system sizes. Geometrical orientation of rods, however, applies across length scales. Though the influence of geometrical features on alignment is not well understood, even for passive systems. IMAGINE_LC will Investigate the Manipulation of Anchoring and Activity via Geometrical Interaction Effects on an experimental, colloidal, liquid crystal system. The colloidal scale minimizes chemical interactions and enhances geometrical effects. I will develop a passive and active model system that is confined by walls with diverse topographical features. The project will be conducted at Utrecht University, where the host has expertise in confined liquid crystals and colloidal synthesis.The host and I will have a two-way transfer of knowledge by employing host expertise in liquid crystal analysis, colloidal synthesis, and high-resolution imaging for this project. These tools are essential for developing a colloidal liquid crystal. My knowledge of molecular liquid crystals is complimentary to the host group’s research focus on liquid crystal assembly. My experience with complex liquid crystal device fabrication will complement the host’s body of knowledge. By combining our expertise, IMAGINE_LC will advance the fundamental unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Adhesive interactions in malaria: new targets for intervention'.

assistant: **Objectives**

Drugs against malaria are urgently needed. The morbidity and mortality inflicted by tropical malaria is associated with the adhesive properties of erythrocytes infected with the malarial parasite Plasmodium falciparum. Sequestration of infected erythrocytes severely compromises the host, resulting in damage to vital organs including the brain. The objective of this research proposal is to develop the technological and scientific base that will permit the rational design ofanti-adhesive drugs for the treatment of severe malaria. This includes a strong research initiative toI) dissect the mechanism of differential vary gene expression;ii) better define the receptor-legend interactions involved in adhesion;iii) investigate post-adhesive events that lead to pathogenesis; and iv)develop an adhesion-disruptive receptor-mimicking carbohydrate. This consortium brings together the leading European scientists in these research areas .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Doctoral School PALPROX “Proxies from Small Vertebrates in Prehistoric Archaeology""""' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The Doctoral School PALPROX fosters a unique interdisciplinary and collaborative research frame in which the Doctoral Candidates will work on their Individual Research Projects around a common program: The use of small vertebrates as a proxy in Prehistoric Archaeology. We aim to focus on the studies of Late Pleistocene small vertebrates to gain insight into the studied taxonomic groups found in archaeological sites, but also to face the new challenges posed by interdisciplinary approaches to archaeological studies, and their contributions to the debate about climate change and biodiversity loss. Small vertebrates, due to their reduced size, small habitat ranges and in most cases low mobility, are known to be more sensitive to regional changes than large mammals and plants, especially in Europe where mountain ranges and sea barriers block their retreat to the south.In addition, fossil small vertebrates can help to modern conservation biology, providing predictive clues based on long-term biodiversity archives. In general, knowledge of the small vertebrate Quaternary record can help to better understand current extinction dynamics, response to climate changes or ecological turning points.Finally, taking advantage of synergies with other disciplines, fossil small vertebrates studies have incorporated new methodologies such as Geometric Morphometrics, Oxygen Isotope studies or ancient DNA, and introducing Geospatial and MaxEnt tools into the analyses of both fossil and modern specimens. These approaches very much complement, but do not replace, a basal training in the fundamental methods based on osteological and morphometric description.As a result, PALPROX will support promising Doctoral worldwide candidates passionate about interdisciplinary research, supporting the incr