RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'The role of islets of langerh ans in autoimmune diabetes, and development of novel therapies by ex vito gene transfer'.

assistant: **Innovation**

Rationale - Insulin dependent diabetes (IDDM) is an autoimmune disease which destroys insulin-producing pancreatic b^ta-cells. Europe, with one million patients, shows areas with highest incidence. IDDM has devastating vascular complications with staggering costs; neither cure nor prevention is available. The aetiology of IDDM is poorly understood. The events allowing escape from immune tolerance to islet auto antigens are unknown; an early islet dysfunction could be directly involved. The effector mechanisms for b^ta-cell destruction also remain elusive. It has been accepted that b^ta-cells are slowly destroyed; this is uncertain, and it is not known to what extent b^ta-cell loss can be compensated bybêta-cell regeneration. These key issues must be solved to design strategies to prevent IDDM or replace the b^ta-cell mass. Ex vivo expansion of native orsurrogate bêta-cells, while technically feasible, have been unsuccessful due to dedifferentiation of engineered cells. Solving these problems may revolutionise IDDM treatment.Objectives - Six European research groups with expertise in the fields of diabetes immunology, bêta-cell biology, insulin gene expression, gene transfer technology and islet transplantation here design a holistic approach to IDDMaetiology with the aim of developing concepts and techniques towards noveldiabetes treatments.Objective 1 is to understand the role of bêta-cell dysfunction and dysregulation of islet antigen presentation in autoimmunity. We will determine the exact role that bêta-cells play in the initiation of the autoimmune process. We propose that neuroimmune dysregulation of is letfunction augments presentation of bêta-cell antigens, these will be identified with islet specific T cell clones.Objective 2 is to clarify the mechanisms of bê
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dosage sensitive genes in evolution and disease' (DOSE).

assistant: **Innovation**

Evolutionary change of gene copy number through gene duplication is a relatively pervasive phenomenon in eukaryotic genomes. However, for a subset of genes such changes are deleterious because they result in imbalances in the cell.  Such dosage-sensitive genes have been increasingly implicated in disease, particularly through the association of copy number variants (CNVs) with pathogenicity.In my lab we have previously discovered that many genes in the human genome which were retained after whole genome duplication (WGD) are refractory to gene duplication both over evolutionary timescales and within populations.  These are expected characteristics of dosage-balanced genes.  Many of these genes are implicated in human disease.  I now propose to take a computational (dry-lab) approach to examine the evolution of dosage-balanced genes further and to develop a sophisticated model of evolutionary constraint of copy number.  These models will enable the identification of dosage-balanced genes and their consideration as novel candidate disease loci.Recognising and interpreting patterns of constraint is the cornerstone of molecular evolution.  Through careful analysis of genome sequences with respect to gene duplication over evolutionary times and within populations, we will develop a formal and generalised model of copy-number evolution and constraint.  We will use these models to identify candidate disease loci within pathogenic CNVs.  We will also study the characteristics of known disease genes in order to identify novel candidate loci for dosage-dependent disease.This is an ambitious and high impact project that has the potential to yield major insights into gene copy-number constraint and its relationship to complex disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Developing an organic fertilizer production system using nitrogen fixing Cyanobacteria'.

assistant: **Objectives**

Global consumption of Nitrogen based fertilizers today exceeds 120 million metric tons a year, mostly originating in the Haber-Bosch process. This industry is a sizeable resource consumer, using 3-5% of the global natural gas supply and accounting for 1-2% of global energy expenditures. It’s also a major contributor to global warming, releasing about 10 tons of CO2 for every ton of N fertilizer produced . This is one of the major concerns that has led to double digit growth rates in organic agriculture in recent years.  However, organic fertilizers currently on the market are expensive, unstable and fail to support robust, commercial growth in hydroponic greenhouses or in advanced irrigation farms. Our innovation produces Nitrogen fertilizer from air and water in an efficient and ecological manner at the actual site of the farm or greenhouse. Cyanobacteria grown in a controlled environment, constantly fix nitrogen from the air into a stable form of ammonia, using the sun as the energy source. The ammonia is then extracted and converted to nitrate by specialized bacteria in an automated process. This solution shifts the way greenhouses acquire their N inputs, from importing an industrial product with a high CO2 footprint to sustainably producing it in situ.GrowPonics utilizes a builder – operator business model - it constructs the project or greenhouse at the client’s site, and then supports its day to day operation. Our clients / partners rely on us to provide cutting edge technologies in horticulture and hydroponics. The cyanobacteria fertilizer project, among others, will contribute to the positioning of GrowPonics as a world leading company in ecological / organic hydroponics and advanced agriculture. Our clients will be able to bolster an ecological branding, and in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Energy and economic efficiency for today’s smart communities through integrated multi storage technologies' (NETFFICIENT) targeting Horizon 2020.

assistant: **Abstract**

The project will deploy and demonstrate local storage technologies which have reached TRL 5-6 in a real electrical grid, and will develop ICT tools to exploit the synergies between them, the smart grid and the citizens. The demonstration in this real environment will be driven by five use cases covering low voltage and medium voltage scenarios and a wide range of applications and functionalities. Viable business models will be defined for the cases, and proposal for changes in regulations will be made. Dissemination and exploitation activities will ensure these results drive market uptake of storage technologies.The expected outcomes of the project are:-An energy management system to be used by the energy companies to manage the energy of their associates´ storage devices.-Control systems to integrate management and decision support tools that enable the integration of renewable generation, forecasting and storage systems into the smart-grid.-Innovative storage solutions: •HESS (Hybrid Energy Storage System – Ultracapacitors + Li-ion batteries)•Second Life Electric Vehicle Batteries•Home Hybrid technologies (Ultracapacitors + Li-ion batteries)-Business models to allow easier deployment of energy storage technologies into the electricity market-Proposed changes to regulators in the social and economic areas in order to lower barriers to the deployment of distributed storage for the defined use cases.-Life Cycle Assessment / Life Cycle Cost of the storage systems used in the projectThe project will achieve topic expected impacts and also environmental and socioeconomic impacts, like carbon emissions reduction and lowering the EU dependency of fossil fuels.The project gives Energy Services Companies (ESCO) a main role in the deployment and exploitation of storage solutions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cell Life Tracking Using Intracellular Lasing Barcodes' (CelLife) targeting Horizon Europe.

assistant: **Abstract**

Our understanding of diseases fundamentally depends on our knowledge of cells, the building blocks of our bodies. Single-cell analysis has evolved over recent decades, from microscopy of individual cells to modern flow cytometry allowing multiparameter analysis of tens of thousands of cells per second. Typically, these methods are limited to a single-pass analysis, offering a snapshot of cell life from which past and future behaviours are inferred. In addition, they often involve separating cells into 1D and 2D cultures, which do not accurately represent in-vivo behaviour and cell-to-cell interactions. However, 3D cultures pose an additional challenge as imaging and tracking of cells become more difficult due to increased light scattering inside the tissue. In this project, I aim to track individual heart cells throughout their life cycle using custom-made microscopic lasers. Initially, cells will ingest multiple microlasers, each serving as a unique spectral barcode for cell identification. The cells will then undergo imaging and deformability assays and a modified flow cytometer analysis to gather comprehensive data about their initial state. Subsequently, cells will be cultured into a 3D organoid, with the position and contractility of each cell tracked by the coherent emission of the microlasers they contain. Finally, the organoid will be dissociated, and the cells will be re-analysed. This approach will yield extensive data on how the environment impacts individual cells, provide a tool to gather new insights into the evolution of cell behaviour and thus enhance our understanding of cellular processes. Further, the fellowship will facilitate my professional development by allowing me to further my understanding of biophotonics. Working with novel techniques in an i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'intelligent Asset Management Platform for Hydropower operation and maintenance'.

assistant: **Innovation**

The iAMP-Hydro project will improve the digital operation of existing plants through the development of 6 expected results (R) which will collectively form iAMP - a novel intelligent Asset Management Platform (see result R5 in Fig. 1) encompassing secure open and transparent data sharing protocols (R4) and three novel digital solutions: R1. Condition monitoring and predictive maintenance modelling; R2. Ecological status monitoring and water management; R3. Improved weather and flow forecasting. The full package of digital solutions will be validated at a diverse set of five real-world existing hydropower plants producing evidence for policy making to support the green and digital transition of hydropower (R6). The existing plants include differing power capacities, electro-mechanical equipment type, water end-use, flow and head regimes, climatic conditions, and environmental sensitivities (biodiversity).The project will increase the technology competitiveness of existing hydro by reducing O&M costs by 5-10%, improving generation and revenues, increasing flexibility and data-driven decision making in hydropower operations. It will also increase the market penetration of renewables in the grid by 8.4 TWh, and getting closer to the EU 2030 Climate and Energy targets, and EU green deal. iAMP-Hydro will improve environmental and socio-economic sustainability of the existing hydropower fleet by reducing operating costs by €1 billion per annum, reducing CO2 emissions by 1260 tonnes, creating 10,000 future-proof jobs, and enabling environmentally sustainable flow regulation using digital solutions.  The project will advance the scientific basis for hydropower digitalization by developing, validating and providing a roadmap for the further development of 5 new digital technologi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'e-Sequence: a sequential approach to engineer heteroatom doped graphene nanoribbons for electronic applications'.

assistant: **Objectives**

Graphene nanoribbons (NR) are quasi-1D nanostructures with discrete band gaps, ballistic conduction, and one-atom thickness. Such properties make them ideal candidates to develop low-dimensional semiconductors, which are essential components in nanoelectronics. Atomically-precise control over the structure of NR (width, length, edge, doping) is crucial to fully exploit their potential. However, current approaches for the synthesis of NR suffer from several drawbacks that do not allow attaining such level of precision, therefore alternative methods need to be sought.e-Sequence will develop an unprecedented approach that assembles stepwise small molecular building blocks into NR to specifically target the most important challenges in NR synthesis. Such approach will enable the preparation of an unlimited number of NR with atomically-precise control over their structure and with almost no synthetic and purification effort, exceeding the limits of existing methods.The impact of e-Sequence will not be limited to NR synthesis but it will also extend to other disciplines, since NR are promising candidates to develop new technologies with applications in electronics, sensing, photonics, energy storage and conversion, spintronics, etc.e-Sequence ambitious research programme will be orchestrated by an independent scientist with an excellent track record of achievements in low-dimensional carbon nanostructures, and who has already established a fledgling and internationally competitive research group. Building on this and on his recent permanent appointment as Research Professor, the award of this ERC project will enable him to consolidate his group, build a portfolio of excellent research, and produce results that compete on the world stage.


**Keywords:** Carbon nanostructures,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'In-silico boosted, pest prevention and off-season focused IPM against new and emerging fruit flies ('OFF-Season' FF-IPM)' (FF-IPM) targeting Horizon 2020.

assistant: **Abstract**

The FF-IPM project targets three highly polyphagous fruit fly (FF) species (Tephritidae) that cause devastating losses in the fresh fruit producing industry, the Mediterranean fruit fly (Ceratitis capitata), a serious emerging pest in northern temperate areas of Europe, the Oriental fruit fly (Bactrocera dorsalis) and the peach fruit fly (B. zonata) two major new (invasive) pests, which pose an imminent threat to European horticulture. The project aims to introduce in-silico supported prevention, detection and Integrated Pest Management (IPM) approaches for both new and emerging FF, based on spatial modelling across a wide range of spatial levels, novel decision support systems, and new knowledge regarding biological traits of the target species, fruit trading and socioeconomics. FF-IPM introduces a fundamental paradigm shift in IPM towards “OFF-Season” management of FF by targeting the overwintering generation when population undergoes significant bottlenecks, preventing, this way, population growth later in season. “ON-Season” control approaches will be generated for different spatial scales considering both existing and developed by FF-IPM tools and services. Innovative prevention tools to track FF infested fruit (e-Nose) and rapidly identify intercepted specimens (Rapid-Molecular-Pest-ID tools) in imported commodities and at processing industries will be produced. Species specific e-trapping systems for the three-target FF will be advanced and employed by novel detection strategies based on spatial modelling. Both “ON and OFF-Season” IPM approaches and detection strategies will be validated in selected locations in eight different countries. FF-IPM generated data on FF response under stress conditions, overwintering dynamics, establishment and dispersion patterns of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unravelling the mechanisms behind bacterial symbiosis in insects' (SymMech).

assistant: **Concept**

Bacterial endosymbionts are widely distributed amongst invertebrates and have an enormous impact upon the biology of their hosts, being responsible for nutrient acquisition, predator protection and interference with the host reproductive strategies. Their ability to reduce vector competence has raised the possibility of using endosymbionts as a strategy to eliminate or diminish vector-borne pathogen transmission to humans and plants. A crucial step in manipulation of symbionts is the elucidation of the genes involved in symbiosis. Symbionts are highly adapted to hosts, thriving in highly specialised niches with little interference from competing microorganisms. The genes that permit this lifestyle are not known in any case, because most symbionts cannot be grown outside their host, thus impeding classic microbiological loss of function screens to elucidate the molecular mechanisms responsible for symbioisis. In this project, I will utilize Arsenophonus nasoniae, one of the few culturable symbionts, to establish for the first time the genes and systems required for symbiotic life. This bacterium infects the parasitoid wasp Nasonia vitripennis inducing lethality in the male offspring (son-killing = sk). The major objective of this project is to elucidate by the first time genes that are essential for the symbiosis between a bacterium and an insect using hypothesis-independent TraDis approach combined with hypothesis-dependent gene knockout approaches. Identification of the genes involved in symbiosis may allow us to modify the host range of symbionts or engineer strains that produce the desired phenotype. Additionally, this project will provide solid ground for the identification of genes involved in reproductive manipulation of arthropods allowing performing symbiont-med
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'VECMAP IPM, a one-stop-shop for the sustainable prevention of urban pests of public health Importance' under Horizon 2020.

assistant: **Concept**

You might assume that pest-borne diseases are relics that belong to the past, but you can’t ignore that mosquito’s, ticks, rodents, fleas, bedbugs, cockroaches and several other very well know pests are often bothering you. And surely you did not remain unaffected when the news about Zika virus, spread during the latest Olympic games, was threatening the future lives of unborn children. We currently witness important changes in ecology, climate & human behaviour that favour the development of urban pests. Global travel and trade, urbanisation and environmental challenges are causing pest related human diseases to emerge. Avia-GIS is aiming to prevent pests from disturbing our lives wherever we are! Most pest controllers still limit their interventions to reactive control using harsh chemicals in a ‘carpet bombing’ setting despite EU regulations 2014, imposing to revert to proactive Integrated Pest Management (IPM) principles. Avia-GIS is a leading Belgian innovative SME established in 2001 who has built research and public authority trust over the past 17 years and developed a unique, disruptive software suite - VECMAP® - that will support society to overcome one of its important health threats, the spreading of Pests of Public Health importance. Avia-GIS grew steadily by 17% per year, having now an annual turn-over of 2M€ and employing 15 highly specialised staff members. With the help of the H2020 Instrument, we will be able to add IPM functionalities and bring VECMAP®IPM to the market. Within 5 years Avia-GIS will enable 3.200 SME pest controllers and 3.600 local authorities to shift to IPM strategies. With the grant we will raise revenue from 2 M€ to 22 M€ in 2023 and headcount from 15 to 58 in 2023 and contribute to the scaling of 7 resellers in Europe. The H2020 g