RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Scanning probe energy loss spectroscopy of Nanoscale Alloy Particles for heterogeneous CATalysis', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Most heterogeneous catalysts take the form of catalytically active nanoparticles dispersed over a support medium. To improve catalytic function and reduce waste, researchers are increasingly seeking to improve the homogeneity of these nanoparticles, whether it be their size, shape or composition. One of the difficulties facing researchers is that the techniques used to obtain quantitative information are typically averaged over ensembles of billions of nanoparticles. Measurements of individual clusters require access to expensive instrumentation such as a scanning transmission electron microscope (STEM). The proposed research will apply scanning probe energy loss spectroscopy (SPELS) to study the composition, size and shape of individual size-selected Pt-based binary alloy nanoparticles for fuel cell applications, deposited using an inert gas-aggregation source. In SPELS, a STM tip is used as a highly localised source of field-emitted electrons to stimulate surface excitations such as plasmons. The energy of inelastically backscattered electrons from the surface is analysed with a spectrometer, so that spectroscopic mapping of the surface can be obtained as the tip is rastered across the surface. This comparatively low-cost method is capable of producing a spatial resolution of 1-10 nm, so that the composition of individual nanoparticles can be sampled. SPELS will be used, in conjunction with STM, to study the composition and surface structure of bimetallic clusters before and after reaction. This data will be correlated with data on the reactivity of the clusters, probed by CO temperature programmed desorption measurements. These measurements will be used to tailor nanoparticle composition and improve homogeneity, resulting in more efficient catalysts.


**Keywords:**
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Designing Future Measures Of Supporting Innovation Through Enterprise - RTO (Research And Technology Organisations) Interaction In Europe'.

assistant: **Objectives**

In it is long-reaching effects the proposed project aims at influencing the patterns of innovation activity and R&D in enterprises (mainly SMEs but in general with relation to large companies). This is a generic challenge facing as good as all European member states. In particular the project focuses on how companies innovate in global value chains and how public support measures, with focus on RTOs , can facilitate these processes. The instrument to achieve this long-term objective will be to set up an INNO-Net project that will tackle the main challenges facing national agencies in supporting innovation activities in enterprises active in global value chains. The overall goal of the herewith proposed Specific Support Action ,DEFINE, is to establish the best possible pre-conditions for developing a high-quality INNO-Net with the above-mentioned focus.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Eruption Source Parameters for Explosive Eruptions in Iceland Over the Last 3 ka' (ESPSI).

assistant: **Concept**

Eruption source parameters (ESPs)—such as erupted volume/mass, plume height, magma discharge, tephra dispersal, and total grain size distribution (TDGS)—are key information for characterizing explosive eruptions and essential input parameters in tephra dispersal models used for real-time forecasting by the Volcanic Ash Advisory Centers (VAACs) and for long-term hazard assessments. Iceland is one of the volcanically most active regions of the world, with over 20 events per century. About ~700 events are preserved in the post-glacial soil and lake sediments in Iceland. ESPs, however, have yet to be determined for most of the eruptions. ESPs are traditionally derived using empirical approaches, requiring detailed field measurements of the deposits. The objective of this action is to estimate, to the first order, the ESPs for explosive eruptions in Iceland using inversion modelling. The advantage of this approach is that it bypasses the compilation of detailed isopach maps through the use of optimization algorithms. It requires only a limited number of thickness measurements and grain size analyses. Consequently, ESPs can be established for a larger number of eruptions in a shorter time, than when using traditional empirical methods. This will result in a statistically robust data set on ESPs used for determining the magnitude and intensities of explosive eruptions in Iceland as well as for assessing risk and mitigating hazards associated with such events.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ENCODE - Unveiling emotional dimensions of politics to foster European democracy' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Despite emotions being a driver of political choices, building democratically meaningful emotional narratives in politics remains an uncharted territory. Hence the main venture of ENCODE is to decode the meanings of emotions and encode them to policy-making strategies aiming for a positive emotional turn, breaking the cycle of depolarisation. To meet this ambitious goal, ENCODE builds its conceptual frameworks arising from a novel concept of affective pluralisation, as opposed to affective polarisation. This term serves to frame empirical research carried out in 6 geographically diverse European countries, representing both EU member states and candidates. This study will span desk research, sentiment analysis, biometric research, in-depth interviews, experiments and panel survey. Such triangulation of research techniques ensures the accuracy and validity of the findings. These are further encoded into main outputs: catalogue of best practice to tackle disinformation in social media, emotional gap maps, validated survey questions and democratic resilience heatmaps. These outputs are not expected only to enhance current scientific framework, but also are planned to underpin the future emotional narratives co-designed by diverse groups of citizens in innovations labs and further validated by Delphi expert panels and vignette experiments. This bottom-up approach anchored in citizen science ensures that policy-making strategy are in first place created by citizens and only in the next step discussed by expert teams who will elaborate policy-making strategies, the roadmap for their implementation, alongside future foresight scenarios which will be disseminated widely across EU and EU wide community of 1000+ members. This strategy creates emotional bonds between ordinary citi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Elucidating the Molecular Mechanisms of Synthetic Saponin Adjuvants and Development of Novel Self-Adjuvanting Vaccines' in the context of a Horizon 2020 call.

assistant: **Objectives**

The clinical success of anticancer and antiviral vaccines often requires the use of an adjuvant, a substance that helps stimulate the body’s immune response to the vaccine, making it work better. However, few adjuvants are sufficiently potent and non-toxic for clinical use; moreover, it is not really known how they work. Current vaccine approaches based on weak carbohydrate and glycopeptide antigens are not being particularly effective to induce the human immune system to mount an effective fight against cancer. Despite intensive research and several clinical trials, no such carbohydrate-based antitumor vaccine has yet been approved for public use. In this context, the proposed project has a double, ultimate goal based on applying chemistry to address the above clear gaps in the adjuvant-vaccine field. First, I will develop new improved adjuvants and novel chemical strategies towards more effective, self-adjuvanting synthetic vaccines. Second, I will probe deeply into the molecular mechanisms of the synthetic constructs by combining extensive immunological evaluations with molecular target identification and detailed conformational studies. Thus, the singularity of this multidisciplinary proposal stems from the integration of its main objectives and approaches connecting chemical synthesis and chemical/structural biology with cellular and molecular immunology. This ground-breaking project at the chemistry-biology frontier will allow me to establish my own independent research group and explore key unresolved mechanistic questions in the adjuvant/vaccine arena with extraordinary chemical precision. Therefore, with this transformative and timely research program I aim to (a) develop novel synthetic antitumor and antiviral vaccines with improved properties and efficacy for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SONOLIS ENERGY STORAGE SYSTEM: Lithium Capacitor Power Transfer', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

One of the main European challenges included in the 2020, 2030 and 2050 objectives and frameworks is the increase of energy efficiency, and the integration of Renewable Energy Sources plays a fundamental role in the development of Smart Grids in order to achieve the targets. However, with renewable energy it is difficult to generate the same quantities of electricity that those produced by traditional fossil fuel generators and it is difficult to guarantee the reliability of supply because of the fact that the production relies on the weather for its source of power, solar collectors need clear skies and sunshine to receive photons and produce electricity, and wind turbines need wind to turn the blades. That is why energy storage is considered to be one of the primary means by which renewable energies can entirely replace fossil fuels. Traditionally, the energy is stored in an electrochemical way but batteries have some associated disadvantages. SONOLIS, an enterprise founded in late 2009 by a group of engineers and entrepreneurs, has developed an innovative Energy Storage System that combines, optimizes and improves the characteristics and performance of two basic technologies available on the market today, super capacitors and the last generation of lithium batteries, which is useful for several applications. The global total storage capacity is expected to achieve 12,000 MWh in 2024, and worldwide revenue from distributed energy storage system is expected to grow from 452 million$ in 2014 to more than 16.5 billion$ in 2024. With this project, SONOLIS will finalize the upgrade and validate its innovative technology, and will commercialize it in the international markets, pursuing a business opportunity that will provide an accumulated turnover of more than 12M€ after
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Personalised Pancreatic Cancer Vaccination Therapy derived from Autologous Tumor Cells and Neoantigens' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

CyTuVax B.V. is a biotech enterprise founded in Maastricht (the Netherlands) in October 2012. It applies depot-formulatedcytokines (interaction molecules of the immune system), which enhance immune responses in an unprecedented mannerwhen used in extremely high local density. Single and multi-cytokine combinations can be formulated by simple proceduresand act as strong adjuvants, driving immune responses to their limits. It is a universal, patented platform adjuvant technologythat can be applied to any vaccines and can have great influence on future vaccine technology. CyTuVax achieved the firstclinical proof of concept in a Phase I trial in which 90% of hepatitis B non-responders were successfully vaccinated. Phase IIis on-going. CyTuVax decided now to focus on the challenging problem of developing a vaccine for pancreatic cancer, adeadly disease for which no curative treatment exists. Its cancer vaccination therapy (PanCaVax) should substantiallyimprove the life-expectancy by extending the median survival rate to at least 12-24 months. Costs of PanCaVax will beconsiderably less compared to checkpoint inhibitor antibodies, with locally strong, but systemically mild, side effectsexpected.  CyTuVax’ highly motivated team’s next step is to complete the preclinical development ofPanCaVax. Key impact of our innovation would be that it is providing a favorable clinical outcome and sufficient proof of efficacy to obtain financial resources for next steps in Phase IIb/IIIa, regulatory approval and ultimate access to pancreatic cancer patients currently lacking an acceptable therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Spermidine in hypertension: therapeutic potential and novel mechanisms' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Hypertension pharmacotherapy, albeit fairly effective, is far from ideal and adequate blood pressure control is only achieved in one third of patients. As such, hypertension is still the global leading cause of cardiovascular disease and mortality. In this regard, we have recently discovered that higher intake of the caloric restriction mimetic spermidine – a potent inducer of the cellular quality control mechanism, autophagy – correlates with lower blood pressure in humans. Administering spermidine to animals also delays the development of hypertension and vascular aging, suggesting it might be useful for disease prevention. However, whether spermidine can be used for therapy, as urgently needed in patients, is still unknown. Thus, the main objective of this proposal is to elucidate the therapeutic benefit of spermidine in established experimental hypertension. Applying a multitude of cutting-edge techniques, including knockout of autophagy genes and metabolic flux, we will provide key mechanistic insights on whether spermidine counteracts hypertension via activating autophagy, upregulating the arginine-nitric oxide axis, or both. With the ultimate goal of translating our findings from animals to humans, we will validate the clinical relevance of these mechanisms in patients' samples. Hence, this proposal will not only reveal a potential novel treatment for patients with hypertension, but will also study a previously understudied cross-talk between blood pressure control and autophagy. If true, we anticipate the project results to pave the way for a novel concept for hypertension therapy. Considering that the work will be done at a leading multi-disciplinary research group, where the researcher will bring expertise in cardiology and receive advanced training in cell bi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Studies of gravity in backgrounds with non-zero cosmological constant' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The objective of this project is to bring to a conclusion the goals that were set in the original proposal. The latter was concerned with a detailed study of the thesis that the quantum gravitational infrared back-reaction slowly generates negative vacuum energy which eventually screens a positive cosmological constant and provides a natural end to inflation in the early universe. So far the perturbative analysis of the screening mechanism has been completed and, using it, real progress is currently being made in obtaining a model for the non-perturbative regime. Such a model will allow a straightforward computation of the relevant cosmological quantities in the early universe. Given the time constraints involved such an objective is quite reasonable.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Representations of europe and the nation in current and prospective member-states: media, élites and civil society' to be submitted under Fifth Framework.

assistant: **Abstract**

This project studies the relationship (intertwined or mutually exclusive) between national identity and representations of Europe and the EU in 9 countries (A, CZ, D, EL, I, HU, PL, E, UK). Differences in the understandings of the nation, Europe and the EU between the media, party elites and lay people are analysed. Attention is paid to the role of the media in setting the discursive universe within which lay people form and discuss their opinions. Country studies are analysed comparatively (South-North and East-West axes). Networking between media professionals and the research community is promoted through the organisation of workshops and preparation and diffusion of policy memos. Concrete media strategies and other policy measures for improving citizen knowledge on European integration and Eastern enlargement are proposed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Biocatalytic alkylation: fitting enzymes for selective C-C bond formations', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Alkylation, in particular carbon-carbon (C-C) bond formation, is one of the most important and challenging synthetic transformations in chemistry. Current chemical approaches for C-alkylation require the use of expensive and toxic transition metals with complex ligands that have limited selectivity. Developing sustainable methods for the controlled formation of C-C bonds with regio- and stereospecificity in high yields has the potential to change organic chemistry and provide access to new molecules. Enzymes, Nature’s catalysts that enhance reaction rates, can selectively catalyze such reactions, with current limitations due to high energy co-substrates and the requirement for specific starting materials, sometimes leading to undesired side products, therefore unsustainable to upscale.I aim at developing the synthetic potential of key oxidoreductase enzymes towards the sustainable selective production of highly valuable compounds through C-C bond formation. Oxidoreductases traditionally catalyze reduction and oxidation reactions and are increasingly used at industrial scale for their mild reaction conditions and exquisite chemo-, regio- and stereoselectivity. I will use the inherent mechanism of two particular oxidoreductases, ene reductases and alcohol dehydrogenases, and develop them towards selective C-C bond formation.BioAlk aims at being disruptive in catalysis and organic synthesis by enabling new approaches for bench mark sustainable methods towards highly selective biocatalytic C-alkylation with industrially relevant oxidoreductases. I will design and develop non-natural enzymatic processes with ene reductase-catalyzed selective inter- and intramolecular α-alkylation of carbonyl and related compounds, and alcohol dehydrogenase-catalyzed nucleophilic reductive al