RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Listening to Silence: The First Blood Test for Risk of Individuals at Prophylactic Time Windows to Develop Type 2 Diabetes Mellitus' (PredRegNetworks).

assistant: **Innovation**

Type 2 Diabetes Mellitus (T2DM) is a heterogeneous disease, associated with mortality and severe morbidity, and affecting hundreds of millions of people around the globe. Despite some misconception accepted in the public, current models to predict the onset of T2DM have insufficient power, and are generally limited to individuals that already progressed into pre-diabetes states, at which the assignment of disease-preventing treatments is largely ineffective. Clinical-level prediction power (AUC>0.9) among non-diabetic individuals would enable effective pre-emptive strategies, but the way to produce such predictions remined unknown. Based on a new understanding of enhancer-silencer regulatory networks, I have developed a new class of supreme epigenetic biomarkers. Disease-prediction models that built on the basis of these novel understanding and biomarkers, significantly overpower the best currently-available prediction models. Importantly, these pioneering models can identify the people at risk well before the appearance of any clinical symptoms. Strong preliminary evidence signified the potential to develop the first clinical test to identify the risk to develop T2DM and associated diseases among non-pre-diabetic individuals at the required prediction power, and in time to deliver effective disease-preventing treatments. Validation of these results and demonstration of the effectiveness of the new clinical-level test will allows the directions of the effective (though expensive) preventing treatments to the people at risk, thus dramatically improve the way we are dealing with this harmful disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Biosignal2000' (BIOSIGNAL2000) targeting Fifth Framework.

assistant: **Abstract**

BIOSIGNAL 2000 international Euroconference is a medium-sized scientific meeting giving a forum to top experts; young scientists and experienced researchers involved in biomedical engineering and related fields. Four general areas are covered: 1) Measurement and interpretation of physiologic signals, 2) Medical imaging and image analysis,3) Physiologic modelling and simulation, 4) Computer based clinical decision-making. These areas include most of the recent problems and problems of near future in biology and medicine: automated medical diagnosis via processing biological signals, graphic display of anatomic detail or physiologic function of man, modelling of living organism behaviour, and computer analysis of patient related data.BIOSIGNAL 2000 should bring new fresh ideas to the field through its central theme BRIDGES TO BIOMEDICINE". The motivation of the organisers is to find hidden connections between engineering and other sciences (mathematics, chemistry, physics, etc.), make bridges for scientists of different fields, and exploit newly developed methodologies and techniques in biology and medicine. A special interest will be given to young scientists.Young scientists competition, Special forum for young scientists and a number of invited lectures done by top experts in the field will give an excellent opportunity to get information on cutting-edge research results and discuss their scientific problems. The conference will be located in the centre of Europe. The city of Brno in the Czech Republic has been selected as a traditional and important centre of biomedical engineering in Central and Eastern Europe. The conference should also give more information to public and arise common knowledge on biomedical engineering and stress its important role in medicine."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Global Knowledge Exchange Centre (GKEC) for Urban Climate Neutrality'.

assistant: **Innovation**

The ambition of the Global Knowledge Exchange Centre (GKEC) for Urban Climate Neutrality is to mainstream actions towards climate neutral and net-zero urban developments on a global level. In this sense, the GKEC will provide support in terms of global outreach for the European Cities Mission as well as contribute to the Urban Transition Mission of Mission Innovation. It will provide effective support and knowledge for local governments and international stakeholders and through this, support European policy such as the European Green Deal and work towards the international commitments of the Paris Agreement.The GKEC will make available evidence and good practice for urban climate neutral and net-zero transitions globally and facilitate capacity building, knowledge exchange and moderated learning for municipalities and key stakeholders. In operational terms, the GKEC will set up actions according to the three impact pathways:1.Mainstream knowledge and good practice to accelerate urban transitions: The mission platform will be extended towards global use, making available international solutions and good practices and promote financing and funding opportunities to implement integrated urban climate action and net-zero pathways.2.Offer advanced frameworks and moderated learning across all governance levels to raise awareness of and capacities for CN and NZ policies: Policy advocacy for climate neutral and net-zero approaches will allow aligning of global policies. Capacity building measures for local and regional actors will provide guidelines and support mutual learning to drive systemic change. 3.Establish the GKEC as a forum for international exchange and cooperation on climate neutral and net-zero transitions: Global and regional events accompanied by comprehensive di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Flexible optical control of neural circuits' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Information representation and processing in the nervous system relies on spatiotemporal activity patterns carried across large populations of neurons. Our ability to perturb or even control these activity patterns thus underlies both basic-science experim ental questions and our ability to restore lost function following neurological damage. This task is typically addressed using electrodes and electrode arrays but can also be approached using optical stimualtion of neurons, for example, by photolyzing cage d glutamate ('uncaging') . We will develop a system that allows flexible, selective optical stimulation of thousands of neurons. Our system uses a rapid UV image projection system to control the dynamic distribution of glutamate release and will be appli ed in a series of in vitro experiments in retinas and brain slice preparations where we will use electrode arrays to monitor the resultng population activity. Using tools from engineering, we will characterize the input-output relationships in our system a nd use them to provide methodical strategy for activating and blocking the activity of neurons in feed-forward and recurrent network architectures. We will also use our system to emulate in retinal ganglion cells the same activity patterns recorded during normal visual input, a basic step towards a retina neuroprosthetic interface based on direct optical stimulation.'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Boosting the efficiency of skin thermoelectrics by developing stretchable nanocomposite substrates with tunable anisotropic thermal and electrical conductivity' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

As the world is rapidly adopting wearable technology, the demand for efficient, self-powering devices is becoming increasingly critical. Thermoelectrics (TEs) are important because they can convert body heat directly into electrical energy to power wearable electronics and enable efficient on-skin heating/cooling for applications such as skin thermoregulation. Existing wearable TE devices inevitably face reduced energy conversion efficiency due to 1) high contact thermal resistance at the interface between the substrate and the skin due to non-conformal contact and poor attachment; 2) high parasitic thermal resistance across the substrate, which is typically a thermally insulating flexible polymer; and 3) high electrical contact resistance between the TE legs and their interconnects due to a poor electromechanical interface. In BEST-TEC, I target a 3-in-1 solution to these challenges by proposing novel skin-like nanocomposites with high mechanical compliance and tunable heat/electrical transport across preferential directions. Used as a substrate for skin thermoelectric (sTE) devices, these nanocomposites will result in a tenfold increase in performance. BEST-TEC is innovative because while most sTE research to date has focused on the development of new materials and device architectures, BEST-TEC addresses a largely overlooked aspect that is currently holding back device performance - the substrate and its interfaces. The project is timely because it will enable new wearable biomedical devices, needed more than ever in our aging population. As the project lead, I possess a robust background in wearables, nanotechnology, and device engineering. My customized devices have been used on diverse surfaces, such as marine animals and human skin, new racing cars, and drones, u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'A pilot programme for regional co-operation: the Southern Africa regional climate outlook'.

assistant: **Objectives**

RTD actions implementing ENRICH are part of accompanying measures of the Environment and Climate Programme, the Marine Science and Technology Programme and the International Cooperation Programme. CORDIS generally does not held information on accompanying measures of RTD programmes. Therefore for further details please contact: Ib Troen, European Commission, DGXII.D.I at ib.troen@ec.europa.eu.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Smart Forms of Collaboration among Inter-Networked Manufacturing SMEs', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

10 SMEs from 4 countries (Greece, Portugal, Germany, Norway) have identified a common business problem: in order to improve their competitiveness on the market they need to establish new smart forms of strategical cooperation. Three typical partnerships have been identified as being of the highest relevance to be examined in the pilots. SMEs have detected that they have to considerably improve the coordinated planning and monitoring of their collaborative work. Therefore, they have to introduce proven IST solutions supporting, planning and monitoring across virtual enterprises based on information/knowledge sharing. The project will be based on the common methodology successfully applied by 3 catalysts in the scope of previous projects. It is likely that the solutions identified in the project will be replicable by a large number of SMEs in Europe. One of the objectives is to disseminate the results obtained to both regional and European audiences.Objectives:The main common business objectives of the 10 SMEs in the consortium are:(a) to maintain and further improve their competitiveness on the market based on innovative collaborative work within an inter-networked organisation;(b) to identify and eliminate bottlenecks in the current, traditional forms of mutual cooperation and find ways to resolve problems related to resistance to a stronger, active partnership(c) to identify the appropriate forms of collaborative work(d) to improve their ability to exploit the opportunities offered by the digital economy by improvement of skills and to prepare themselves for further networking with other companies.For the 3 catalysts the objectives are to further enhance the existing BEP methodology especially in reference to best practices in the collaborative work of inter-networked
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeting of retrograde transport vesicles in the endoplasmic reticulum' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The secretory pathway of eukaryotic cells comprises several specialized membrane-bound compartments. Transfer of proteins between these compartments is mediated by transport vesicles. A correct targeting of these vesicles is accomplished by interactions between integral membrane proteins on the vesicles and target organelles, termed v-SNAREs and t-SNAREs, respectively. SNAREs required for anterograde transport from the endoplasmic reticulum (ER) towards the plasma membrane are already known. The discovery of a novel t-SNARE on the ER of yeast allows us to investigate for the first time the targeting of retrograde moving vesicles in the secretory pathway. Since both anterograde and retrograde v-SNAREs must be present on the same vesicles, either as targeting molecules or recycling passengers, it is possible that some of the vSNAREs involved in forward transport also have a role in retrograde traffic. The genetic and biochemical studies described in this proposal offer a unique opportunity to determine whether any of the known v-SNAREs act in this way or whether there is a separate set of retrograde vSNAREs to be discovered. Our investigations should contribute to a better understanding of how eukaryotic cells maintain their compartmental organization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Improvement of leather fastness properties' to be submitted under Fourth Framework.

assistant: **Abstract**

The transfere of colour and fibre from the surfaces of leathers to other fabrics in contact with them is a major problem to the industry. To maintain their market share and position it is imperitive that leather fastness standards match those of other modern textiles. The proposed project is designed to examine each element of the problem and applying polymer technology and establishing proven best practice, improve dye fastness and minimise/abolish loose fibre/dust production to attain the required product performance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Role of 14-3-3 proteins in intracellular signalling; characterization of interaction with raf-1 kinase'.

assistant: **Innovation**

14-3-3 proteins play a role in many cellular functions: they bind to an regulate several proteins which are critical for cell proliferation and differentiation. Most notably 14-3-3 interacts with and potentially regulates Raf-l, Bcr and protein kinase C. The crystal structure of 14-3-3 has recently been solved at NIMR and it is now important to determine the structure of this protein in a complex with protein kinases. The specific objective of this proposal is to determine the atomic structure and the mechanism of the interaction with Raf-l, a Ser/Thr kinase which plays a key role in the MAP kinase cascade. The project involves the expression and purification of various Raf-constructs and the biochemical and biophysical characterization of the 14-3-3/Raf interactions and the subsequent crystallization of stable 14-3-3/ Raf-l complexes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Piezoelectricity in 2D-materials: materials, modeling, and applications' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Piezoelectricity in two-dimensional (2D) materials is increasingly important because of its potential in realizing thin yet efficient and flexible piezoelectric devices. In contrast to traditional three-dimensional (3D) piezo- and ferroelectrics that are prone to size effects, piezoelectricity in 2D materials may be controlled by flexoelectricity and interfaces thus providing significant piezoelectric effect in ultrathin films and crystals. Equally important, the majority of 2D layered piezoelectrics found so far possess in-plane piezoelectricity and require bending of flexible substrates to activate piezoelectric effect. This severely limits their integration with modern Si technology. This project aims at strengthening the piezoelectric activity in 2D materials via interface and stress engineering and bond control in order to reach the maximum efficiency and other relevant figures of merit. The materials list includes hafnium-zirconium oxide (HZO), transition metal thio/selenophosphates (TPS), graphene on oxide substrates, and polymer PDVF. A comprehensive investigation of piezoelectricity in these 2D materials and their relevant device performance is still at an initial stage and needs European support. Concerning piezoelectric energy harvesting, Piezo2D will build a technology to provide local energy generation (microgenerators) from the nm- to the micro-scale to power nano- and microdevices. Piezo2D will do so by enhancing and deploying the combined powers of equilibrium and nonequilibrium thermodynamics and atomistic models with device physics and engineering. Research results will underpin future developments of nanoscale energy devices for decades to come. We will also develop new characterization techniques and metrology-inspired protocols aiming at future stan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Heritage buildings and objects' digitisation & visualisation within the cloud'.

assistant: **Objectives**

HERITALISE mission is to research and develop advanced digitisation techniques and solutions for documenting and representing diverse CH assets, giving a full comprehension of the diverse CH features, visible and non-visible. In addition, AI-powered tools including Machine Learning (ML) will be developed for improved and optimised data post-processing and integration based on standard and expanded methodologies. All this will be connected through a knowledge graph environment that allows the individual aspects known about the CH object to be related and retrievable. As with Wikipedia, by following links it will be possible to learn more about a particular object, what research has been done, and what results have been derived from it.HERITALISE will provide the upcoming ECCCH with a interoperable web-based Ecosystem, advanced input data from improved digitalisation methodologies and preservation supporting tools, which will be achieved by meeting the following General Objectives (GO) and setting the conditions for a wide-scale replicability and scalability across European CH institutions/organisations across European CH institutions/organisations:GO1: State-of-the-art review of current digitisation standards and methodologies defining the data requirements for CH tangible and intangible objectsGO2: Improve 3D/2D Data acquisition methods and technologiesGO3: Data post-processing methods and technologies will be adopted, including new AI-powered digitisation methods and the development of data fusion techniques to mix various multimodal digitisation approaches (multisensory, multiscale, multispectral, external and internal)GO4: Development of methodologies and solutions as Hardware (HW) and/or Software (SW) services GO5: Development of ECCCH-compliant open interoperabilit