RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PREdictiVe system to recommend Injection mold sEtup in Wireless sensor networks' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The objective of PREVIEW is to develop a Cyber Physical System (CPS) for plastic injection manufacturing processes monitoring, control and optimization, by incorporating several innovative and cutting edge technological solutions: advanced artificial intelligence and machine learning techniques, robust industrial wireless communication, IoT and indoor location. PREVIEW is a middleware solution that facilitates easy, ubiquitous, holistic and fast sharing of product and process information across the entire injection production process.PREVIEW development incorporates several innovative technological solutions:-PREVIEW Advanced Predictive system offers a powerful knowledge based system for data analysis. Based on the data analysis results compared to historical data, the system will provide feedback, closing the loop by recommending actions to improve productivity; -PREVIEW will develop and implement the Data acquisition modules to collect the data from the in-mould cavity pressure and temperature sensors as well to collect data from the injection machine PLC;-Thanks to the data acquisition modules and the industrial wireless communication capabilities developed in the project, mould and machine become IoT-capable, allowing for interoperability at intra-plant level with other devices, including the PREVIEW server, database and mobile devices such as tablets and smartphones;-PREVIEW system offers the possibility to share among the Cloud the mould-DNA functionalities as well as the Setup Predictive System. These functionalities enable to reuse historical data when setting up a mould in another location. PREVIEW deploys a set of technologies and enablers (Information and communication technologies, manufacturing strategies, modelling, simulation and forecasting methods and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Differential Involvement of Electrically Coupled Networks in Brain Oscillations' in the context of a Seventh Framework call.

assistant: **Objectives**

It is generally assumed that the brain generates behavior through the electrical activity of neurons. Information coding relies on coordinated activity of neuronal assemblies. This cooperative activity of central neurons is embodied in the oscillations and synchronization of neuronal activity among different frequencies bands. The mechanisms allowing the emergence of neuronal oscillations are variable and include fast synaptic transmission and electrical coupling between interneurons or principal cells but their speific role in each frequency domain remains to be elucidated. The implication of inerneuronal gap junctions in hippocampal gamma oscillations has been demonstrated using mice lacking the neuronal connexin gene Cx36. However, the study of the implication of electrical synapses in theta oscillations and ripples (ultrafast oscillations) has led to controversial results, and suggests that other coupled networks expressing other connexins might be involved. This project (outgoing phase) aims at testing the impact of different ellectrically coupled networks (interneurons and pyramidal cells) in hippocampal network activity and hippocampus-dependent learning. For this purpose, hippocampal rhythms will be compared in Cx36 (expressed in interneurons) knocked-out mice, and Cx36 and Cx45 (expressed in pyramidal cells) double KO mice. This will be done using large-scale recordings of unit activity and local-field potential recordings in animals chronically implanted with 16-site silicon probes, during spontaneous episodes of slow-wave and rapid eye movement sleep, wheel running and alternation task. During this post-doctoral training, I will learn large-scale recordings and analysis of neuronal population activity in the hippocampus in behaving animals. The return phase w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Transport in strongly interacting nanosystems' (TSINANO) under Sixth Framework.

assistant: **Objectives**

The proposed research concerns non-equilibrium transport properties of nanosystems such as quantum dots and quantum wires. This is a timely topic, where fundamental issues of physics are at stake, and numerous technological applications possible.This project is particularly interested in the influence on transport properties of the interactions, of the coupling to the environment, and of strong quantum effects. One of the specific aims is to find new ways to detect charge fractionalization, spin charge separation, and fractional statistics in one-dimensional systems.Another aim is to deepen our understanding of current experimental setups, by taking into account features not accounted for in previous research due to the lack of proper mathematical tools. The applicant's expertise in perturbative approaches (in particular the Keldysh formalism) will be combined with the host's expertise in non-preservative methods of quantum field theory to make progress on some key questions.Among those are: the possibility of detecting charge fractionalization in multiple current correlators, the possibility of observing physical consequences of fractional statistics, the properties of third and higher cumulants of the noise, the role of superconducting leads (as opposed to metallic leads).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ALKENPHOS Ligands: Innovative Electronically Responsive Scaffolds for Metal-Catalysed Syntheses' in the context of a Sixth Framework call.

assistant: **Objectives**

Bidentate ligands are key components in many metal-mediated syntheses of organic molecules vital to pharmaceuticals and materials production; their chelate nature provides control and selectivity.Related systems with two different donors (heteroditopic ligands) also give an asymmetric coordination environment that greatly alters a metals reactivity and catalytic behaviour. Continued ligand design remains crucial to the development of clean, efficient, sustainable manufacturing processes based on atom efficient metal-catalysed reactions.A flexible synthetic strategy for the preparation of novel, bidentate phosphine-alkene ligands based on norbene skeletons (ALKENPHOS) will be developed, using simple P-N and -O bond-forming reactions. Two families of ligands will be prepared. A 7-aza-norbornene frame will provide rigid scaffolds offering an ideal metal binding pocket, while less rigid P-alkene ligands will be prepared from 2-hydroxy-norbene.Both systems are a major departure from the types of heteroditopic ligands that have been prepared to date, presenting two very electronically and sterically different donor sites. This feature will provide control and unique reactivity for the resulting complexes by maximising the difference in Lewis basicity, pi-acidity and trans-influence between the two sites.The easy synthesis of ALKENPHOS ligands allows for the easy introduction of chirality, important for their use in asymmetric catalysis. The readily available 1,1-binaphtholate-derived P-fragment is attractive since it is easily built-in and is very successful in asymmetric catalysis.After quantification of their basicity/donor properties and preliminary coordination chemistry studies, the ALKENPHOS systems will be used in a range of homogeneous catalytic reactions that will ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mechanisms of drug action and drug resistance in mycobacteria' (1994-1998).

assistant: **Concept**

To investigate the influence of cell permeability and drug efflux systems on drug susceptibilityTo identify the resistance mechanisms to streptomycin and clarithromycinTo study the mode of action of isoniazidTo characterise the cellular function of aminoglycoside acetyltransferase genes and their role in aminoglycoside inactivationTo search for a potential mdr gene in M.tuberculosisCharacterisation of drug resistance mechanisms at a genetic and biochemical level is a prerequisite for design and development of new drugs endowed with a high degree of selectivity that will prevent or curtail the spread of resistance conferring mutations. Implementation of new technology for rapid recognition of drug resistance will result in early initiation of effective chemotherapy as well as in preventing further transmission.The project focuses at several aspects of mycobacterial drug resistance: acquired resistance to first-line drugs; mechanisms of the high inherent drug resistance; role and function of chromosomally encoded acetyltransferases; investigation of drug combination effects; multi-drug resistance genes. The project uses a multidisciplinary approach targeting resistance mechanisms at several levels, e. g. cell wall permeability, drug efflux, drug modifying enzymes and identification of intracellular targets of drugs. The project will allow the mechanisms of drug action and drug resistance to be elucidated both at the genetic and biochemical level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Implications of Gender-Affirming Hormone Therapy for Psychosocial Functioning and Social Relationships of Transgender People'.

assistant: **Objectives**

Transgender health is an area of increasing focus for researchers and medical practitioners across Europe, in part due to rapidly escalating numbers of people identifying as transgender.  A crucial oversight in this area is that very little research has examined how gender-affirming hormone therapy, the most common form of medical intervention for transgender people, shapes psychosocial functioning and ultimately social relationship experiences.  Given the paramount importance of social relationships to health and well-being, evidence for psychosocial effects of gender-affirming hormone therapy is vital to ensuring health equity for transgender people, who suffer from alarmingly high rates of social disruption and suicide risk.  I draw together independent strands of research on biological effects of hormones from social neuroendocrinology and health influences of psychological and sociocultural factors from social psychology and epidemiology to propose a novel biopsychosocial model linking gender-affirming hormone therapy to psychosocial functioning in transgender people.  Drawing upon this model, I propose a programme of research involving four complementary work packages, triangulating across a variety of novel and cutting-edge research methods.  This work will be guided by three key aims: A) to isolate causal pathways from a biopsychosocial model linking gender-affirming hormone therapy to psychosocial functioning, B) to empower transgender people to give voice to their own personal and relational experiences in the context of gender-affirming hormone therapy, and, C) to guide policy and practice for gender identity services in line with the informed consent model, directing focus to the improvement of psychosocial functioning and social relationship outcomes.  This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CHemotaxis Inhibitory Protein of Staphylococci CHIPS""' (CHIPS).

assistant: **Innovation**

Inflammatory disorders are considered to be the underlying cause of at least 50 different diseases, many of which are disabling or even fatal, i.e. heart attack, rheumatoid arthritis, asthma and stroke. Current therapies are mainly treating symptoms and not the basic disease mechanisms and many of them have disturbing side effects.In the proposed project a strategic partnership will be formed between a Swedish biotech SME, AlligatorBioscience AB, and an academic partner, the Eijkman Winkler Institute at University Medical Centre in Utrecht. Alligator specialises in development of protein based drug candidates. The unique asset of the company is the proprietary protein engineering technology FIND (Fragment INduced Diversity), which is speedy and makes it feasible to develop drugs from starting material so far not appropriate for human use. UMCU has frontline expertise in the interaction between bacteria and the human immune system, and in highly specialised cell based functional assays and animal models.The immediate objective of the project is to pursue two different approaches to develop novel drug candidates for the treatment and basic disease modification of inflammatory disorders. The first involves de-immunisation of an already identified molecule (CHIPS) derived from Staphylococci, the second involves development of small antibody fragments that mimic the CHIPS action. The CHIPS molecule was developed by UMCU, and the group has also shown the therapeutic potential of the substance.Further development has however so far been abandoned because of a strong immune response elicited by the molecule. The combined efforts and expertise areas of the two partners will now make a new development possible. As a long term objective the collaboration will provide both partners
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Modelling water splitting reactions at the electrochemical interface under operating conditions' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

This project will investigate aqueous semiconductor interfaces for water splitting applications, using advanced computational chemistry methods. Green hydrogen, produced from water electrolysis using renewable energy, is expected to play a key role in the energy transition and cover approximately 10% of the EU’s energy needs by 2050. One promising production route is using photoelectrochemical cells (PECs), where photogenerated charge carriers in semiconductor electrodes catalyse the hydrogen and oxygen evolution reactions. However, the commercialization of PECs is hindered by low efficiencies, material instability, and cost.Optimizing the performance of PECs requires a thorough understanding of the solid/electrolyte interface under operating conditions. These systems are challenging to probe experimentally, and most computational studies, while extremely useful, often ignore the experimentally relevant effect of the applied electrode potential. Moreover, the few approaches that allow the incorporation of bias in the simulations, come with several shortcomings, such as relying on implicit solvents or requiring the use of prohibitively large systems for the accurate modelling of semiconductors.With bismuth vanadate (BiVO₄) as our model system, in this project we will leverage recent advances in computational chemistry to (i) develop and apply machine learning interatomic potentials to simulate BiVO₄ in contact with explicit water and selected electrolytes, (ii) examine the impact of electrode potential on interfacial structure and electronic properties, and (iii) explore water oxidation pathways using enhanced sampling techniques. This project will advance the atomic-scale modelling of electrochemical interfaces in realistic conditions through an integrated simulation fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CarMen' under Horizon Europe.

assistant: **Concept**

Challenges related to “on the move” biometrics are 1/ lower quality live biometric data, and 2/ no time to read the ePassport. Also, fully automatic biometric border control solutions, even with a stop allowed, are currently deployed only for pedestrians in controlled environments. Carmen innovates biometric solutions for non-stop border control, suitable for pedestrians and vehicles, in uncontrolled environmental conditions. Travellers’ authentication is achieved in two steps: 1) the biometric data (face, iris, periocular) of travellers is securely stored in their smartphones, thanks to a DTC (Digital Traveller Credential); 2) the biometric data is securely transferred from the DTC to the border authroity infrastructure, and compared to the live biometric data collected as the traveller crosses the border control point.To address a variety of environmental conditions, Carmen uses both NIR and RGB live biometric images and compares them to the reference images that have been acquired with one type of lighting only. To make biometrics more robust, Carmen has a multimodal approach on face iris and periocular regions. In fraud detection, Carmen detects presentation attacks on moving travellers and detects anomalous traveller behaviour. To address small and large border crossing points, Carmen enables the use of fix and body-worn cameras. To address travellers in cars or lorries, Carmen detects face images in slowly moving vehicles, through the windows.Travellers in coaches are controlled by border guards walking through the coach, using dedicated portable equipment as they walk.Carmen addresses the robustness of DTC via data injection attacks. Carmen complies with the existing legal and ethical standards, and privacy is a central concern.Carmen solutions will be demonstrat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Genetic and immunological safety of dna vaccines' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The injection of a DNA plasmid containing a gene encoding an antigen under the control of a eukaryotic promoter is a novel approach to vaccination which has received considerable attention in the past few years. Immune responses have been induced with genes from a variety of infectious agents including influenza, HBV, HIV, rabies, LCMV, malaria and mycoplasma. Protection from disease has been reported. The USA has made significant progress in this field and a clinical trial of a DNA vaccine has already begun. There are several safety and regulatory concerns regarding this form of vaccination. - The injected DNA may integrate into the host chromosome resulting in a transformation (or tumorigenic) event, - Injected DNA may persist and be expressed for a considerable time within the recipient which could lead to the induction of immunopathological reactions, tolerance or antigenic competition, - The inclusion of genes for regulatory cytokines, which may improve the immune response, may have serious consequences such as the stimulation of one arm of the immune response at the expense of the other leading to generalised immunosuppression or chronic inflammation. To date, there is a paucity of scientific data in relation to the above issues regarding the safety of DNA vaccines. Two reports exist investigating whether integration of a DNA vaccine into the host chromosome occurs. The results were negative although the methods were not validated. There is a similar lack of information on potential immunopathological reactions. In order to ensure the safe application of DNA vaccines, the specific objectives of this project are: - to validate methods for assessing integration of a DNA vaccine into the host chromosome, - to apply such methods to the analysis of potential integratio