RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cross Talk between Resistance Mechanisms to Pathogen Infection in Cereals' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

Cereals are the most important renewable resource for food, fodder and industrial raw material. Diseases of major crops such as barley and other cereals remain the most significant global constraints to production and quality, with large and unpredictable economic and environmental costs associated with chemical control.In their natural environment plants are subject to simultaneous challenges by a variety of biotic (biotrophic and necrotrophic fungi, viruses) and abiotic stresses (necrogenic agents, temper ature). Programmed cell death (PCD) is not exclusive to resistance mechanisms to pathogens, as hallmarks of apoptosis have been observed in plants exposed to the abovementioned stimuli. Therefore PCD can be associated with resistance, in some cases to susc eptibility leading to disease and environmental stresses. It was recently shown that these stimuli interfere with the outcome of RNA silencing-mediated defence (RMD) mechanisms. This aspect, so far understudied, is of importance as virus outbreak occurs as a result of change in environmental conditions. Therefore it is not only important to understand the molecular aspect of the plant response upon challenge by each individual agent but as well to investigate their respective role in response to challenge b y different pathogens. We propose to investigate the molecular mechanisms associated to PCD in response to challenge by fungal pathogens in barley and investigate the effect of stress on virus accumulation and the nature of RMD response in barley. A functi onal analysis of the barley transcriptome in response to fungal infection using the recently developed barley GeneChip microarray will be undertaken. This project will exploit virus-induced gene silencing approach in barley, currently used to elucidate the fun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Improved precision of nucleic acid based therapy of cystic fibrosis' (2002-2006).

assistant: **Concept**

The epithelial sodium channel (ENaC) is assumed to play a major role in the pathogenesis of chronic lung disease incystic fibrosis patients. Its natural regulation by the cystic fibrosis transmembrane conductance regulator (CFTR)appears to be compromised based on the impaired function of CFTR. The missing downregulation of the channel results in increased absorption of sodium ions and fluid across airway epithelia leading to the depletion of the peculiarly liquid layer and to the depression of mucus clearance. Several observations suggest that a downregulation of Ancestors the perciliary liquid layer, thereby rehydrating the mucus and improving ciliary clearance in the lung. Therefore we propose to specifically downregulate ENaC expression by RNA interference. For this purpose we develop and apply new means of nucleic acid precision targeting both on the molecular and macroscopic level. The first level of precisionist introduced by the use of ENaC-specific siRNA, a technology known for its high downregulating specificity. The second level of precision is brought about by uPA-receptor binding and nuclear localization peptide modules of novel nonviral molecular constructs for nucleic acid delivery. Protein transduction domain peptides will be used for the delivery of synthetic siRNA. A level of loco-regional precision is contributed by the administration of such constructs via the airwaysupon aerosolization. Yet another and novel level of precision and targeting is introduced by the association of viral and nonviral constructs for siRNA delivery and/or expression with magnetic nanoparticles, such that lung-specific accumulation and retention can be mediated by external magnetic fields. For this purpose novel magnetic vector formulations as well as magnetic field generatin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Computational design of proteins binding nucleosomal DNA with specificity for therapeutic applications' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

DNA compresses in the cell by forming nucleosome particles, which diminish the accessibility of transcription factors to DNA and provide fine regulatory mechanisms for gene expression and replication. Some proteins can still bind the exposed face of nucleosomal DNA and are known to promote cancer or viral infection, and strategies to block such binding events are promising for developing new epigenetic-like therapies. However, structural information on proteins binding nucleosomal DNA is too limited for the rational design of new drugs. The current proposal aims to combine expertise of the researcher (on protein design) and the host group (on DNA and protein-DNA interactions) to computationally design and experimentally test proteins binding nucleosomal DNA with specificity. The researcher will first develop a computational design protocol and subsequently test it against nucleosomes of known structure. After experimental validation, he will design proteins blocking the nucleosomal DNA sites targeted by two proteins (FoxA1 and GATA) known to promote breast and prostate cancer. The proposed project uses computational approaches for designing protein structures and protein-DNA interactions, and experimental approaches to characterize protein-DNA binding and structure of the designed complexes. This multidisciplinary project is devised to expand the design capabilities of the researcher towards protein-DNA interactions, which hold great potential for medical and biotechnological applications, in a research context of high biomedical impact. This project devises a training plan on computational, experimental and transferable skills necessary for an independent research position, and provides an opportunity to bring protein design approaches into the European research. The n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Coding for DNA Storage'.

assistant: **Innovation**

DNA-based storage has attracted significant attention due to recent demonstrations of the viability of storing information in macromolecules. Unlike classical optical and magnetic storage technologies, DNA-based storage does not require electrical supply to maintain data integrity, and given the trends in cost decreases of DNA synthesis and sequencing, it is estimated that within the next decade DNA storage may become a highly competitive archiving technology. However, existing coding solutions to address various problems associated with implementations of DNA-based storage systems are very limited in their development.The goal of this research is to develop coding methods and techniques by designing novel and advanced solutions that are specifically targeted for the unique structure and error behavior of DNA-based storage systems. The proposed analytical framework will allow to address coding-theoretic challenges arising in the context of synthesis, storage, and sequencing of DNA strands. To achieve these goals, we aim to design codes for clustering, trace-reconstruction techniques, error-correction codes, and constrained codes. These codes are applicable for long-term storage and recovery of data recorded in DNA, while overcoming the unique challenges associated with the DNA storage channel.We expect that knowledge, techniques, and qualitative insights gained in our investigation will advance DNA storage technologies capable of accommodating the massive amounts of data. Furthermore, solving the proposed coding problems will require new methods and ideas that will also impact adjacent scientific disciplines such as bioinformatics, combinatorics, and theoretical computer science. Thus, the proposed investigation is likely to lead to the development of new paradigms and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Microfluidic Multi-Micropollutant Remediation' under Horizon 2020.

assistant: **Concept**

The rapidly growing impact of xenobiotic chemicals (Endocrine disrupting compounds) on the environment has prompted the development of new processes for the treatment of wastewaters produced by industries and municipalities. Recently, European Commission voted to re-examine its drinking water and commission decided to include three Endocrine disrupting compounds (Bisphenol A, Nonylphenol, and 17β-Estradiol) in the list of benchmark parameters for drinking-water monitoring, in line with latest recommendations of the World Health Organisation (WHO). Recently, the capability of lignin-modifying enzymes for degradation of xenobiotics and recalcitrant pollutants has generated a considerable research interest in this area of industrial/environmental microbiology. Lignin-modifying enzymes can be also used to break down and reduce the harmful activity of hazardous substances, due to the similarity of their chemical structure with that of lignin.  The goal of this innovative project is to relate the expertise of the ER in ligninolytic enzymes with the expertise of a start-up in microfluidics and microfluidic systems. By combining these two technologies, we aim at creating a superior, more efficient system able to rapidly perform the treatment of wastewaters. The resulting system should be small, energy-efficient (involving low pressures, typically below 200 Pa), and made of a high number of microfluidic layers to allow for a high wastewater volume treatment (typically up to 50 m3/day). The high-volume high-efficiency target will be made possible using a microfluidic technology developed and patented by the host company. The resulting technology is foreseen to address the current challenge of increasing water pollution and bring affordable, sustainable solutions for all communiti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Physiologically relevant microfluidic neuro-engineering' under Horizon 2020.

assistant: **Concept**

Developing minimalistic biological neural networks and observing their functional activity is crucial to decipher the information processing in the brain. This project aims to address two major challenges: to design and fabricate in vitro biological neural networks that are organized in physiological relevant ways and to provide a label-free monitoring platform capable of observing neural activity both at the neuron resolution and at large fields of view. To do so, the project will develop a unique microfluidic compartmentalized chips where populations of primary neurons will be seeded in deposition chambers with physiological relevant number and densities. Chambers will be connected by microgrooves in which neurites only can grow and whose dimensions will be tuned according to the connectivity pattern to reproduce. To observe the activity of such complex neural networks, we will develop a disruptive observation technique that will transduce the electrical activity of spiking neurons into optical differences observed on a lens-free platform, without calcium labelling and constantly in-incubo. By combining neuro-engineering patterning and the lens-free platform, we will compare individual spiking to global oscillators in basic neural networks under localized external stimulations. Such results will provide experimental insight into computational neuroscience current approaches. Finally, we will design an in vitro network that will reproduce a neural loop implied in major neurodegenerative diseases with physiological relevant neural types, densities and connectivities. This circuitry will be manipulated in order to model Huntington and Parkinson diseases on the chip and assess the impact of known drugs on the functional activity of the entire network. This project will en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Code of Good Practice for Farm Animal Breeding and Reproduction' (CODE-EFABAR).

assistant: **Innovation**

The European farm animal breeding and reproduction organisations organised in FAIR (Farm Animal Industrial Platform) will develop, discuss and implement a Code of Good Practice for Farm Animal Breeding and Reproduction. SME representatives will develop the technical elements for the Code, a research organisation will develop the ethical and society elements needed in the Code, an organisation will develop the certification requirements, and another one will develop the communication elements and strategy. The draft Code will be discussed by the European breeding and reproduction organisations in a workshop, after which the Code will be developed further into a - final Code. Furthermore, European breeding and reproduction organisations will receive training on the implementation of the Code in their organisation, along their wishes as an informal Code or as a Code recognized and controlled by an independent body. The Code will be available at the FAI P web site, and disseminated to breeding and reproduction organisations and, among others, policy makers and society organisations (e.g. environmental, welfare and consumer organisations). In the future, FAIP will take the responsibility for the maintenance of the Code.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The role of Western lifestyle factors in smoke-induced inflammation in chronic obstructive pulmonary disease' (IRESOLUTION) under Seventh Framework.

assistant: **Objectives**

Over the past century a substantial increase in the incidence of chronic inflammatory diseases has been observed in industrialized countries. This unexpected rise in diseases such as chronic obstructive pulmonary disease (COPD), asthma and inflammatory bowel disease has led to concern about how Western lifestyle may negatively influence our (anti-)inflammatory defense mechanisms. Inflammation is a process that needs to be actively terminated with help of anti-inflammatory and pro-resolving mediators. Several of these mediators are derived from molecules in our environment such as sunlight and nutrition. Accumulating evidence now suggests that Western lifestyle results in a lack of sufficient exposure to sunlight and insufficient intake of particular nutrients due to our diet, resulting in a reduced availability of essential anti-inflammatory and pro-resolving mediators in the body. The work described in this proposal aims to map the role of anti-inflammatory and pro-resolving mediators in smoke-induced inflammation in COPD. The outcomes of this study are expected to contribute to a better understanding of the resolution phase of inflammation and result in the identification of novel therapeutic targets that are applicable for COPD and possibly more inflammatory diseases. Obtaining new insights in the mechanisms underlying resolution of inflammation is of utmost importance to provide a foundation to curb the rise in inflammatory diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'META DATA ANALYSIS LAB to Enhance Training Quality'.

assistant: **Concept**

How are you? A simple question and people’s answers to it lead to a disruptive plan. The interdisciplinary approach to semantic analysis and machine learning is a shift of paradigm in endurance training, rehabilitation, and health precaution. It will boost our business and solve a problem all personal trainers have. There is a natural growth limitation in 1:1 care because of time consuming efforts. Machine learning helps us to systemize and up-scale what we already do successfully. Listening and understanding are the key competences for our corporate promise: “Achieve Your Goal Healthy!” We have developed a plan with global implications for e-health.We will show how we are going to transform the results of machine learning from particular data sources into a must-have application for trainers and for their clients. The proposal shows how this can be done on large scales with a little help from our competitors. Thereby we include an underestimated data perspective in sports, but health care too. We want to find out, how to implement and up-scale our strategy that leverages trainer’s best practice internationally. A simple solution and a starting point from within a market niche will lead to a disruptive innovation. The outcome will enable huge business opportunities not only in sports, but in rehabilitation and health precaution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cooperative ITS for Mobility in European Cities' (CIMEC).

assistant: **Concept**

Call topic MG3.5-2014 notes that the deployment of C-ITS has not kept pace with the technological development, implying that deployment is being restrained by non-technical factors. CIMEC, as a proposed CSA for this topic, aims to support the accelerated take-up of C-ITS by increasing the alignment of technological solutions with user needs, thereby removing perceived barriers and risks in deployment.European highways authorities are relatively well educated, prepared and supported regarding C-ITS, including through a series of EC- and national funded R&D projects. However the greatest benefits are expected through the more complex and fragmented city context, which up to now is much less understood. CIMEC focuses especially on this urban C-ITS context.CIMEC brings together key collaborative institutions, supported by a panel of core cities and by the European city network Polis. This meta-network has extensive experience in bringing together cities and suppliers to optimise ITS, and has specific expertise in a range of C-ITS at national and European level.The objectives of CIMEC are to•capture and document a set of realistic use cases for C-ITS in cities, supported by robust business cases•identify practical project structures which enable the deployment of these use cases•identify how emerging standards for C-ITS will affect, and should respond to, urban systems and processes•show possible system architecture and workflow of C-ITS support systems •promote multi-sector stakeholder dialogue, engagement and collaborationThe principal output will be a roadmap for city deployment of C-ITS which has been validated against user needs and technology maturity, captured in meaningful project descriptions. By developing a single, coherent narrative and communicating it effective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Transcribing the processes of life: Visual Genetics' (VISGEN) under Horizon 2020.

assistant: **Objectives**

The Visual Genetics (VISGEN) consortium brings together eight academic and five commercial scientifically leading teams to address the unique challenge of visualizing nuclear processes in intact brain in real-time. By exchanging knowledge between academic and commercial sectors in Europe, as well as undertaking training secondments at leading Universities in China the team will grow its European and global competitiveness in a world-leading forefront of neuroscience and genetic technology. Visualisation of transcription in living systems has not been witnessed directly, this multidisciplinary and international project will herald a new era where this idea becomes a regular research tool and translates to a clinical and diagnostic technology in the future. The team will use a unique biotagging platform to develop the technology that is required to interrogate transcription. The intersectoral effort requires the amalgamation of knowledge from neuroscientists, synthetic chemists, engineers, physicists, analytical chemists, nanobiologists, behavioural scientists, laser technology and image processing experts. The consortium combines expertise from thirteen organisations from seven countries to build the multidisciplinary team and share the knowledge that addresses and will overcome the task of realising real-time and spatially resolved  genetic studies. Once developed, the technology can be utilized for other medical-based research and development projects aimed at early stage disease diagnosis, cancer detection, and toxicity studies. Real-time visual genetics will transform our understanding of the state-of-the-art and herald transformative changes in the field of neuroscience, and in general life science.


**Keywords:** Raman spectroscopy