RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Alpha-1 international registry' (1998-2002).

assistant: **Concept**

Alpha-1-antitrypsin deficiency (AAD) is a rare inherited disorder on chromosome 14q32.1 that predisposes to liver, vascular but especially early onset, rapidly progressive lung disease. As recommended by the WHO in 1996 in Geneva, we have established an international registry in January 1999 and developed a simple database and DNA bank, now containing over 300 European patients with AAD. The proposed Action is to execute a study using genome-wide linkage and association studies in DNA samples, to find other genetic risk factors explaining why some smokers with the inherited deficiency develop lung emphysema, while others with the same smoking history dont. Furthermore, we aim to use existing European databases on air pollution to find correlations with clinical data and/or new genetic information in a two year longitudinal study with AAD patients. Funding is requested to enable the logistics around the two proposed studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'PROMOTING EUROPEAN INNOVATION CULTURE' (PROINNO) under Fourth Framework.

assistant: **Objectives**

Previous experience has shown that the non-technical factors show the most promising potential for improvement in the innovation process. The project was focussed on the field of European cooperation and European management of innovation production. The basis of PROINNO was the analysis of European Innovation culture, its barriers and its potential resources, which could be optimally exploited so as to maximise European innovation and creativity. The partners represent different national, institutional and professional cultures of organisation and management styles.The goal of the project was to develop, test and disseminate an integrated set of information and support measures for transnational project teams (case reports, information brochure, computer tool, www-server-pages, workshop designs). These tools would promote the organisational capacity of transnational European project groups and joint ventures to create, exploit and disseminate technological innovations.The project objectives were:- the development of workshop conceptions with the objective to improve international project planning, monitoring and evaluating, team building, communication and cooperation in international project groups, the international exploitation of project results and its transfer and dissemination into different national and organisational contexts- a revised and enlarged brochure (a booklet), and a computer disk to support European project management, cooperation, team building in multi-national and multi-professional project teams- dissemination of project results and existing tools and measures via the internet.A series of workshops took place with the following target groups: project coordinators, prospective project coordinators, Pparticipants of innovation projects within the E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'BOOST - Cooperation in Urban Science, Technology and Policy' in the context of a Seventh Framework call.

assistant: **Objectives**

Cities are increasingly seen as ""engines of regional development"" and the main competitive hubs within a global web of economic, knowledge and physical flows. Cities are fertile ground for science and technology, culture, entrepreneurship and creativity. However, cities are also places where problems are concentrated, such as the decoupling of economic growth and employment, social and spatial segregation, poverty, environmental degradation and climate change.Europe’s competitiveness depends greatly on its cities and metropolitan regions, where enterprises can benefit from agglomeration economies and networks linking regional, national and global market places. In order to address the major challenges of cities a Joint Programming Initiative Urban Europe was launched in 2010 with the ambition to rethink and manage the increasing urban orientation and concentration in Europe and to create and exploit synergy in an urbanised Europe from an economic, social, environmental and transport-related perspective, leading to a strengthened position. 13 EU Member States and Associated Countries have therefore joined forces to coordinate and align their research programmes in order to boost urban research and innovation.BOOST – Cooperation in Urban Science, Technology and Policy, aims to support and strengthen the further establishment of JPI Urban Europe and facilitate effective internal and external communication of this initiative. It will do so by further establishing effective JPI governance structures, bridging scientific gaps, facilitating networking, launching a Research Alliance, outreach to the scientific, policy, industry and civic actors involved in urban development and by stimulating coordination efforts with stakeholders, funding agencies and other international pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evolution of the genetic architecture of quantitative traits' (EvoGenArch).

assistant: **Concept**

A major challenge in evolutionary biology is to understand and predict the evolution of phenotypic traits influenced by many genes, a.k.a. quantitative traits, which represent the majority of adaptive traits. For this, we require an accurate knowledge of the genetic architecture of a trait, here defined as the statistical distribution of the effects of the genes on the phenotype. However, it has not been possible to firmly check theoretical predictions against empirical data, due to a lack of method to accurately infer genetic architecture.In this project, I will develop novel statistical methodology to accurately infer the genetic architecture of traits in the wild, by leveraging the statistical correlation between neighbouring sites in the genome, or linkage disequilibrium. Using the power of a new linked-read sequencing to obtain information on recombination, I will apply this novel methodology to study the link between the genetic architecture of the traits, and the evolutionary regime, i.e. characteristics of selective and neutral factors. First, I will perform an in-depth study of the link between selection and genetic architecture on a long-term-studied wild population of common lizards. Second, I will apply my method to analogous traits across more than 20 species to infer their genetic architecture and use knowledge about the evolutionary regime and phylogenetic context, to assess the influence of those components on the variation in genetic architecture.By combining novel methodology with analysis within and across species, this project will provide a firm empirical basis for thinking about genetic architecture. In turn, this understanding of the expected distribution of the gene effects, depending on the evolutionary context, will improve our ability to forec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'E3Car -> Nanoelectronics for an energy efficient electrical car' (E3CAR), addressing dissemination and exploitation.

assistant: **Impact**

The objective of the project is the development of nanoelectronics technologies, devices, circuits architectures and modules for electrical cars/vehicles and demonstration of these modules in a final systems.Emissions from road vehicles have to be reduced substantially in the future. The ultimate goal of most car manufacturers is to get to a completely electric vehicle, protecting the environment from emissions and noise, with alternative on-board energy sources (solar) and connection to the grid. In this context the project is addressing the development of highly efficient electrical vehicles, the battery control, the high-voltage components (IGBTs, high-voltage FETs) and the architectures and subsystems for the electronics of electrical vehicles. The project considers both vertical integration with the final user and equipment providers and horizontal cooperation to build a solid nanoelectronic technology base for Europe electrical car industry and establish standard designs and platforms for electrical/hybrid cars. The project will consider architectures, technologies and modules being applied to electric vehicles on systems and sub-system levels.  New design and concepts are considered for power train, power conversion, power management and battery management. These systems are considered fail safe and fault tolerant and new methods and technologies for improved reliability and increased lifetime will be developed during the validation phase. In this context the power and high voltage electronics and smart miniaturized systems for power management, engine control and energy recovery systems will be specified and developed, based on the voltage / current range of needed modules. This results in research activities concerning MOS/DMOS or IGBT-Technologies to become hi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The limits of the sciences in identifying causes and scientific laws' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Scientists rarely question the scientific methods – and their related complex theory, strong assumptions and problematic quantitative techniques – used to generate the causes and laws in their particular scientific models, which is the guiding research question of this project. Better understanding the limits of using mathematical and statistical methods in science is important for research and policy, because these methods all lead to some degree of biased results and scientists using them often misguidedly claim to establish strong causal relationships. This research project will investigate the underlying assumptions of quantitative methods by critically assessing the leading, most cited academic studies across the sciences that all use some form of mathematical and statistical methods. By combining theoretical, methodological and empirical analysis, this research project will help disentangle the links between the actual methods applied by scientists and the causal effects and scientific laws they claim to identify in their models. Identified causes and laws need to always be understood in the context of the different methods used to express them. This research project thus aims to address the gaps in the literature on scientific methodology by providing insight and knowledge into the large set of important assumptions and limitations behind mathematical and statistical methods used to identify causes and scientific laws. By helping to increase awareness among scientists about these biases and constraints and by outlining ways to better combine multiple methods, this project also aims to help improve scientific practice. More broadly, it hopes to help improve how we understand scientific methodology and thus science and evidence-based policymaking.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Touch and action in spatial perception' (TOUCHANDACTION).

assistant: **Innovation**

When we notice a mosquito on our arm, we can easily reach out without much conscious thought. This simple act conceals a difficult computational problem for the brain. When a stimulus is applied to the skin, the initial representation is a somatotopic map of the skin surface, which takes no account of the position of the limb. Given the movable nature of some body parts, for tactile information to be used in orienting behavior, the representation of its location must be remapped to reflect the position of the limb in external space, in a process named tactile remapping.Despite the key motor component implicit in this framework, to date, tactile remapping has been studied exclusively in the context of perceptual systems. This project builds on the idea that tactile processing should not be categorized as an encapsulated module for perception alone, but as a part of a larger system whose final purpose is spatially-coordinated action (reaching, looking, grasping). Hence, this proposal aims at revealing the putative relation between the motor system and tactile perception in external space. The line of research is scientifically challenging but bears the promise of bringing groundbreaking insights into how the brain represents external locations. In essence, this fellowship explores the intriguing possibility that, from the brain's point of view, space is simply a construct of the motor system.The topic of this research is clearly multidisciplinary as it spans several research areas such as cognitive psychology, neuropsychology and neurophysiology. It combines several methods: psychophysics, electroencephalography and non-invasive brain stimulation. Finally, this research would be conducted in the group of Prof Haggard, at the Institute Cognitive Neuroscience (University Co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Optical Platform for Therapy and diagnostic Imaging in Minimally Invasive Surgical Endoscopy'.

assistant: **Concept**

With the clinical drive for earlier detection of disease and minimally invasive treatment, there is a paradigm shift of imaging and therapy towards in vivo, in situ surgery. One major effort towards this goal is the translation of emerging optical diagnostic imaging and therapy techniques into minimally invasive surgery (MIS) and cancer screening. This proposal will develop a novel multimodal platform that can be deployed in flexible endoscopy and robotic assisted MIS devices. This is timely in that recently there have been advances in the optical detection of diseased tissue states and also in nanotechnology that allows photothermal therapies based on focused optical energy delivery to gold nanoparticles. The clinical integration of these two strands of research offers significant promise for optical adjuvant cancer therapies and for image-guided tissue fusion, but the study of the therapeutic effect of these techniques has been limited due to the lack of a common platform for image-guided optical follow-up of the therapy. The purpose of this proposal is to develop a programmable light source for simultaneous multimodal screening and image-guided nanoparticle-mediated thermal therapy. The platform will be validated by studying of diseases of the colon to enable detection and treatment of flat polyps that may develop into invasive cancers. As a young lecturer, Dr Elson has extensive multidisciplinary experience in laser technology, biophotonics, optical imaging, microscope technique development, minimally invasive surgery and robotic-assisted surgery. He will bring together new technology with a mix of engineering, biochemistry and biophotonics skills. The proposed work will be carried out in state-of-the-art facilities with access to the clinic for translation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Centre of Excellence for Research on Environment, Health and Aging' (CEREHA), addressing dissemination and exploitation.

assistant: **Impact**

Objectives:CEREHA - Centre of Excellence for Research on Environment, Health and Aging is structured to be an inter- and multidisciplinary centre led by MIGAL. This project is the most important research initiative of the Galilee region in Northern Israel. The main objective of CEREHA is to become internationally known research institute, which is capable of initiating and performing excellent interrelated studies in environment, health and aging.Activities:CEREHA will study the aging phenomena employing biological, medical, environmental, epidemiological and social perspectives. Such research requires the creation of a unifying umbrella that will bridge across the inherent fragmentation in science and aggregate the research efforts, especially in human potential across the whole Mediterranean region. The project is encompasses of 6 research institutions, including public and private sectors from Denmark, Germany, Italy, the Netherlands, Norway and USA. The work-plan is divided into 8 WPs, including Management and Ex Post Evaluation. The other WPs are constructed to pave the way to excellence and include secondments from and to partners, upgrade of existing experimental and research facilities, cycles of seminars and international contacts with other research and business organisations, and finally activities geared towards a regional dimension, in view of sparking a competitiveness dynamic in the Galilee. The dissemination activities are also directed to raise complementary funds by the Israeli government.Expected impactCEREHA will create a high quality and high visibility Centre, which will encompass research on health and environment in relation to aging. This Centre, will strive to get input from several other Centres of Excellence in Europe and in the US. This know
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Improving the Quality of Life of Millions through the Revolutionary Approach in Dermal Regeneration Care' (Everfill).

assistant: **Innovation**

The combination of ageing populations, sedative lifestyle and unhealthy diet results in increase in such diseases as diabetes. One of the outcomes of diabetes is the occurrence of very severe and deep leg wounds. As diabetes distorts the body’s normal tissue regeneration processes, it often results in necrosis and amputations, which are still everyday practice even in developed countries. Everfill Oy is a university spin-off that has developed Everfill®, a patented allogeneic bioengineered product that will revolutionize the care of wounds. Everfill® uses extracted human bioactive growth factors that trigger the patient’s body to regenerate damaged tissues. This results in faster and more thorough healing. As Everfill® contains only human material and triggers the patient to regenerate own tissue, it is a superior product for dressings and wound gels. It is safe and well tolerated and has no side effects. Everfill® will enable curing currently incurable tissue defects and wounds, achieve massive savings in health care, and improve the quality of life for millions of people. Our estimate of its global revenue potential is over €350 million per year.So far €0.7 million were invested into the scientific research conducted at the University of Tampere and related to Everfill® product. In order to launch the product commercialization phase, we are looking for €5 million funding for 2019-21, of which half from venture capital investors within the ongoing round A and another half from the SME Instrument. This funding will be used for gaining EU and US regulatory classification for the product, building up business process proof of concept to produce the product for clinical trials, and conducting the first phase of clinical trials in EU. Initial sales revenues from experimenta