RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A new circular economy concept: from textile waste towards chemical  and textile industries feedstock' (RESYNTEX) under Horizon 2020.

assistant: **Objectives**

The RESYNTEX project aims at designing, developing and demonstrating new high environmental impact industrial symbiosis between the unwearable blends and pure components of textile waste and the chemical and textile industries. The project comprises:- a strategic design of the whole value chain from textile waste collection, until the new marketable feedstock for chemical & textile industrie, by which the symbiosis opportunities are evaluated (by public authorities and the private sector) in terms of their social, technical, economic, environmental and legislative aspects- the improvement of collection approaches particularly for non-wearable textiles for recycling by changing citizen’s behaviour and creation of tools for higher social involvement and recycling promotion. This will ensure a greater accessibility to textile waste as resource and increase the textile waste rates destined for recycling. With 50% collection rate all over Europe would be a significant improvement in order to provide large quantities of feedstock- a data aggregation system that will be developed and implemented in order to ensure waste traceability and also provide relevant data for economic and environmental assessment;- the development of new business models adapted for different synergies identified and for new markets. In addition, environmental LCA and LCC for different scenarios and identification of the most promising routes and synergies will support this objective- automation of the macro separation and sorting for pure or blended textiles, in order to enhance productivity and competitiveness of the whole recycling process- a new demonstration process based on a synergistic chemical and biotechnological cascading separation/transformation approach of textile basic components (protein
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The impact of TFIID on the transcription initiation machinery – a structural perspective.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Transcription is a first step of gene expression, a process by which a functional gene product is synthesized based on genetic information from DNA. Gene expression is tightly regulated with complex mechanisms that give cells the flexibility to adapt to a variable environment. Defects in regulation and transcription mechanisms leads to serious pathologies in cells and organisms, that in humans includes cancer development, autoimmunity and neurological disorders, cardiovascular diseases etc. Structural studies of transcription in the last two decades, brought priceless insight into the mechanisms involved in the process, especially concerning transcription initiation. The next step in understanding gene expression is to combine knowledge about gene regulation with the mechanisms of transcription initiation. I will investigate the molecular basis of gene regulation and transcription initiation interplay using strategy that combine state-of-the-art cryo-electron microscopy, chemical cross-linking, mass-spectrometry and biochemical assays.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Science and Technology Advancing Governance of Good Environmental Status' (STAGES).

assistant: **Innovation**

The Marine Strategy Framework Directive is designed to deliver “Good Environmental Status” (GES) in EU marine waters by 2020. This Directive requires that Member States (MS)  with marine territories put in place measures to achieve and maintain GES within a defined timeframe and according to eleven key descriptors of environmental status. However, there is a significant knowledge deficit which may hinder full implementation of the MSFD and the achievement of GES in EU waters.STAGES (Science and Technology Advancing Governance on Good Environmental Status) project is designed to directly address this knowledge deficit. The project has to overarching goals: i) to synthezise  per major MSFD themes the information from research projects and ii)  to develop a platform to ensure that the knowledge generated through European science and technology can be channeled to a broad range of relevant end users, to inform and facilitate implementation of the MSFD and the achievement of GES. To achieve this, STAGES will target a number of critical gaps in the knowledge transfer process. Firstly, STAGES will identify and synthesize relevant existing EU research results and make them available in a usable format for decision and policy making authorities. Through comprehensive scientific foresight targeted at MSFD knowledge gaps, STAGES will identify needs for futher research. STAGES will also develop innovative solutions to achieve an effective collaboration between the broad range of stakeholders necessary to support MSDF implementation, including policy and governance, science, industry and civil society. Moreover, the role and input of MSFD stakeholders will be central to the activities of the project and to the proposals for a science policy interface which will be delivered by the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Decellularised Extracellular Carpets for the Innovative Production of Human Engineered Replicates'.

assistant: **Innovation**

The major roadblock in the commercialisation of cell-derived products is the prolonged ex vivo culture period required to develop them. Macromolecular crowding (MMC), a biophysical phenomenon that increases the kinetics of biochemical reactions and biological processes by several orders of magnitude, allows for the accelerated development of cell-derived products. This project will exploit MMC in the development of cell-derived products in 2 technical and 3 commercial work-packages, increasing the international competitiveness of European-based biotech industries and creating new employment, markets and revenue. This 18-months interdisciplinary and intersectoral project will train 1 post-doctoral researcher at the forefront of scientific research and technological innovation. The project will be carried out at University College Dublin, Ireland’s largest university, one of Europe’s leading research-intensive universities and in the top 1 % universities world-wide.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Politics of the Latent Educational Cleavage' under Horizon Europe.

assistant: **Concept**

One of the most important changes of the last 200 years is the massive educational expansion and the related shift from industrial to post-industrial societies in countries around the globe. This educational revolution has reshaped our societies and economies. But it also transformed politics: Nowadays, education affects almost every aspect of politics. A new systematic conflict line has emerged: the educational cleavage. Its emergence has not gone unnoticed. But existing research remains scattered across disciplines and subfields and has not developed into a comprehensive research agenda yet.POLEDUC offers a comprehensive research agenda on the POlitics of the Latent EDUcational Cleavage across countries, over time, and across three analytical levels: the micro-level of individuals’ attitudes, perceptions, identities, and behavior; the meso-level of organized political actors; and the macro-level of (unequal) representation in the politics of policy-making. POLEDUC develops a unified multi-dimensional theoretical framework and offers novel, ground-breaking empirical analyses, combining quantitative, qualitative, and experimental state-of-the-art methods. On the micro-level, POLEDUC uses existing and conducts new public opinion surveys to study the educational cleavage across countries and over time, surveying the general population and higher education students in particular. On the meso-level, we analyze the party politics of the educational cleavage using qualitative and machine learning tools plus an expert survey. On the macro-level we explore whether and why policy-makers are increasingly responsive to more educated citizens, using comparative case studies. Overall, POLEDUC studies a phenomenon of utmost social and scientific relevance. It breaks new theoretical a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Probing the neural processes underpinning perceptual decisions on a continuum', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The neural computations underlying perceptual decisions have been a central interest for psychology and cognitive neuroscience for decades but, to date, this work has largely focussed on decisions with just two potential outcomes. Yet, in daily life we make countless decisions along a continuous dimension and the precision of these choices is of critical importance, such as when judging the direction of a tennis ball or adjusting course to avoid obstacles while driving. How does the brain implement such decisions while balancing the need for speed and accuracy? Separate parallel breakthroughs in computational modelling and neural signal tracing now provide me with an unprecedented opportunity to address this challenge and gain a mechanistic understanding of continuous-outcome decisions. I will be trained in innovative electrophysiological methods recently developed by my proposed supervisor, which will allow me to trace neural markers of the decision process in the human brain using electroencephalography. These signals will provide powerful constraints on a new computational model for decisions on a continuum that I worked on at the University of Melbourne. My unique background and expertise will allow me to incorporate methods from psychology, neuroscience and engineering to develop a novel computational and experimental paradigm that stands to have a major impact on basic and clinical research in the field of decision making. In so doing, the work will create a collaboration and skill  exchange between three highly complementary labs in Dublin and Melbourne. After several years abroad, I will have the opportunity to reintegrate into the scientific community in Ireland and establish vital collaborations with world-class neuroscientists and clinicians at the Trinity Co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An affordable, easy to use tool for monitoring the wine production process, based on FTIR/ATR and an attached PAS gas cell' (VITISPEC) targeting Seventh Framework.

assistant: **Abstract**

The wine industry, which is made up of thousands of SMEs and family business, is an important contributor to the EU economy, providing countless jobs in vine cultivation and harvesting, wine production, bottling and distribution. However, the sector faces severe problems. Consumption is down, and exports from the New World are making huge inroads into the market. Over the last decade, imports have grown by 10% per annum, while exports are only increasing slowly. On current trends, excess wine production will reach 15% of annual production by 2010/11. The modern wine industry needs tools for process control and quality assessment in order to better manage the fermentation process, which is critical in determining the ultimate quality of red wine. During fermentation it is important to measure both substrate and product concentrations (sugars, phenolic compounds, etc.). However, analysis of these compounds by traditional means requires sample preparation, and in some cases several purification steps, proving time consuming, laborious and prone to human error, while offering no real-time data. To this end, this project aims to develop an affordable, reliable on-line tool for the rapid monitoring of red wine fermentation. Novel inspection techniques will be researched to determine their potential for predicting critical wine fermentation parameters. A prototype VITISPEC on-line monitoring system will be designed, developed and tested in a modern wine making facility and calibrated against existing methods. The results of this project will add real value to EU wine producers by raising the quality standards and consistency of their wine, strengthening Europe’s position as a leading wine producing region of the world and safeguarding the growth of many rural economies across
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Quality of skin as a barrier to ultra-fine particles' to be submitted under Fifth Framework.

assistant: **Abstract**

Today' s population is increasingly exposed to ultrafine particles (<20 nm; e.g. Aerosil, TiO2) contained in body care and household products. Tape stripping studies and recent ion microscopy pilot studies revealed that such particles in, liposomal formulations penetrate the horny layer with large concentrations at the stratum granulosum and the possible risk of further penetration into vital tissue, especially for skin with an impaired barrier function. Here, apart from electron microscopy, high-resolution ion-microscopy techniques will be employed on skin cross-sections from biopsies (pig, human), which yield elemental maps of both the epidermis and dermis with ppm sensitivity for Ti or higher sensitivity with radiotracers (labelled TiO2) on pig skin. Pathways for percutaneous uptake and clearance will be studied. If such particles penetrate into the dermis, in-situ studies of tissue and in-vitro studies of particle-cell interactions follows.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular resolution with focused visible light' (SPOTLITE).

assistant: **Concept**

We intend toppling one of the most prominent paradigms in science: the diffraction resolution limit of an imaging or writing system relying on focused light. To achieve this goal we will pursue a radically new concept. We argue that effecting a reversible saturable transition with a focal intensity distribution featuring one or more local zeros should allow imaging and writing at the molecular scale. Compared to reported efforts (from our own group), the imaging and the writing shall be performed at 1000 to 1,000,000 times lower power. Unlike the established electron beam and scanning probe approaches, our technique accesses the sample's depth. Thus it will allow the non-invasive 3D-visualization of live cells and the writing of nanostructures in 3D. Imaging live cells on a macromolecular scale (<10 nm) would revolutionize our understanding of cellular function and disease. Verification of our concept will profoundly impact the field imaging and may even challenge the current multibillion efforts in nanolithography to translate optical technology into the problematical deep-UV and X-ray regime. Our endeavour does not fall into the thematic priorities of FP6. It is risky but footed on quantitative predictions. Requiring joint efforts of chemists, biologists, and physicists alike, a broadly based breaking of the diffraction barrier is a truly interdisciplinary task. Conversely, light-based nanoscopy would reflect back on these disciplines as well as on their commercial exploitation. Our success will enhance the capabilities of key industrial areas, as diverse as the biomedical industry and information technology. The project's ambition is to establish optical nanoscopy in the same way, as the scanning probe microscopes were established in the 1980's. Breaking the diffract
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'International Co-operation actions on CO2 capture and storage' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Following the commitment made by the Kyoto protocol, the ED countries are challenged to reduce the emissions of carbon dioxide (CO2) by 8% during 2008-2012. The majority of the CO2 emissions within the EU originates from burning of fossil fuels. As demonst rated by an IEA forecast analysis and the WETO study, fossil fuels will continue to be the dominant source of energy, not only in the EU, but also in a global context. There are several options for CO2 reductions in the power and heat sector. The whole cha in - capture, transport, and long-term storage of CO2 - is an important component of the proposed measures to reduce CO2 emissions during the period of transition, whereby renewable energy systems replace fossil fuels as the main energy resource. Applicati on of this concept will allow a gradual evolution in the energy supply system, minimising adverse effects on the European economy and ensuring security of energy supply, whilst adhering to internationally agreed goals for C02 emissions reductions. This Spe cific Support Action, lnCA-CO2, aims at strengthening European excellence and enhancing technical competitiveness of Europe in the area of CO2 Capture and Storage (CCS), by: - Providing to European stakeholders support for the international forums such as CSLF (Carbon Sequestration Leadership Forum). - Establishing international relations with international projects and programs (US, Canada, Japan, Australia) for exchanging information on past and ongoing projects, and identifying opportunities for future c o-operation. - Analysing new information on CCS and providing a coherent view on international activities for input in policy. The consortium is composed of 7 research institutes, key-players in the co-ordination of past and ongoing research projects, act ive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nature Self-medication: Poisoning the microbes a Toll for wildlife' under Horizon 2020.

assistant: **Concept**

Global pharmaceutical consumption is rising with growing and ageing human population and more intensive food production. Recent studies have revealed pharmaceutical residues in aquatic ecosystems and organisms. Among pharmaceuticals, antibiotics, which are natural, synthetic or semi-synthetic compounds, able to kill and inhibit growth or metabolic activity of microorganism, are one of the most widely used categories. Environmental concentrations of antibiotics are often low, but their continuous discharge in the environment, exposes aquatic organisms during their entire life cycle. There is currently little data on the non-therapeutic effects of antibiotics. The microbiota represents the trillions of microorganisms inhabiting a host. Gut microbiota contributes to the development of an immune response, to metabolic processes and it influences the host behaviour. Gut microbiota is very plastic and recent insights have suggested that most diseases could be linked in some way to an alteration of the gut microbiota (i.e. a dysbiosis). However, no studies so far have investigated the impact of antibiotic residues on wildlife’s gut microbiota composition and its effect on disease occurrence. Top predators of aquatic ecosystems such as mustelids are exposed to high levels of pollutants and are considered as keystone sentinel species for the study of pollutant effects on wildlife. Mustelids are also a reservoir species to zoonotic disease, as they are exposed to diverse types of viruses that can be passed from and to domestic animals and humans. The aims of this research action are to 1) determine the ‘natural’ variation of gut microbiota composition according to biological factors, 2) investigate a threshold effect level for which pharmaceuticals could lead to health effects, 3