RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Finding the missing links in the bacterial cell cycle' (MissingLinks) targeting Horizon Europe.

assistant: **Abstract**

The bacterial pathogen Staphylococcus aureus is currently the second most common cause of death associated with antibiotic resistant infections. The most useful antibiotics in clinical use have multiple targets, as compounds against single proteins rapidly succumb to the capacity of bacteria to develop resistance. To think innovatively about antibiotic discovery, we need to think not only about individual cellular processes, but also about how they are interconnected and coordinated, so that we can devise methods to strike bacterial cells, simultaneously, in multiple pathways. The bacterial cell cycle consists of a series of coordinated events required for bacterial growth, during which cells duplicate their mass and undergo chromosome replication and segregation, assembly of the division machinery, cytokinesis, and cell separation to generate two new daughter cells. Unregulated cell cycle progression may have lethal consequences for the cell and therefore bacteria have evolved various mechanisms for the precise spatiotemporal control of main cell cycle events. Some important checkpoints have been studied, particularly the link between chromosome replication/segregation and septum synthesis, to avoid DNA breaks. However, the mechanisms for coordination of other cell cycle events are still unknown. What triggers initiation of peptidoglycan synthesis, the target of beta-lactam antibiotics, after assembly of the division machinery? How does the cell coordinate synthesis of the membrane and peptidoglycan, the two major cell surface components, during cell division? What prevents premature septum splitting, which would expose an immature cell surface, devoid of virulence factors, leading to pathogen elimination by the innate immune system of an infected host?The aim of this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Polycystic ovarian syndrome: novel molecular characterization and personalized in vitro maturation protocol.' (POMOLIM) under Horizon 2020.

assistant: **Objectives**

Polycystic ovarian syndrome (PCOS) is the leading endocrine and metabolic disorder in women, with a prevalence of 5-20%. It is characterized by hyperandrogenism, ovulatory dysfunction, polycystic ovarian morphology and infertility. Epigenetic factors have garnered attention in the pathogenesis of PCOS since changes in DNA methylation and gene expression have been reported in various tissues. Whether these alterations are also found in PCOS oocytes remains unknown. Cumulus cells (CCs) are specialized cells that maintain paracrine signals and cell-to-cell communications with the oocyte to support the acquisition of competence to derive an embryo. This crosstalk is important in PCOS since the reduced oocyte competence is considered the potential causative factor of infertility. PCOS women seeking in vitro fertilization (IVF) treatments suffer greater sensitivity to hormonal treatments, which can lead to a high risk of ovarian hyperstimulation. In vitro maturation (IVM) of oocytes has been introduced in the human fertility clinic as a mild-approach alternative to conventional IVF as it requires minimal stimulation of the ovaries. However, there is a need to further develop a better protocol that curtails the 30% gap efficiency existing between IVM and IVF. This project aims to 1) generate DNA methylation and gene expression profiles of PCOS oocytes and paired CCs using single-cell and low-cell parallel sequencing, 2) create an improved, safe and robust IVM system that can increase oocyte competence for these patients and 3) define the molecular pathways that are differentially regulated in oocytes and CCs after in vitro maturation. The project will benefit from the experience in fertility treatments and safety assessment of the host supervisors, Profs. Smitz and Anckaert. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Silicon opto-electro-mechanics for bridging the gap between photonics and microwaves' (SPRING).

assistant: **Innovation**

Conversion between electrical and optical signals enabled the use of near-infrared (near-IR) photons for high data rate transmission through optical fibre networks. Likewise, coherent conversion between microwave and optical photons stands as a promising solution to transfer quantum states between remote quantum processors, thus enabling the development of large-scale quantum networks. However, the vast frequency difference between microwave (GHz) and near-IR (200 THz) optical photons hampers direct coherent conversion. This limitation could be circumvented by phonon-mediated transduction, which is a coherent two-step process, comprising electromechanical and optomechanical conversions. On-chip microwave-optical conversion mediated by GHz phonons has the potential to be extremely efficient due to the large optomechanical response of common materials, and the similar wavelength of GHz phonons and near-IR photons. Yet, it is an open challenge to achieve efficient electromechanical and optomechanical conversion simultaneously in a single integrated circuit. State-of-the-art demonstrations show that surface acoustic waves (SAWs) allow efficient electromechanical conversion, while cavity optomechanics utilize tightly confined optical and mechanical modes to yield strong optomechanical coupling. However, combining these two approaches is still considered challenging, if not impossible. The SPRING project will overcome these limitations by developing a fundamentally new optomechanical coupling approach to bridge SAW electromechanics and cavity optomechanics. The original idea is to use subwavelength nanostructuration of silicon cavities to couple tightly confined optical modes and SAWs. The SPRING strategy will be used to demonstrate coherent microwave-optical conversion of si
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New Generation Design Methods for Stainless Steel Structures' in the context of a Horizon 2020 call.

assistant: **Objectives**

Current structural steel design codes are based on traditional limit state criteria, in which uncertainties are accounted for through partial coefficients when checking members and connections. However, within the frame of resilient and sustainable cities, it is necessary to choose optimised and sustainable construction materials such as stainless steel, as well as to accurately predict the behaviour and failure of structures by means of system-based design approaches. One method that fits these criteria is the Direct Design Method (DDM). Its applications span from the optimized design of new structures to the safety assessment of existing ones (for reutilization or evaluation after possible damage due to time-degradation or intentioned harm). The DDM directly evaluates the system’s strength from finite element analysis without requiring member and connection checks, thus leading to the design of safer, lighter, more economic and potentially faster designs. More importantly, failure modes of the structure are apparent, making it possible to consider the consequences of failure in design and achieve a consistent system reliability. However, there is a need for research to develop system resistance factors based on rigorous system reliability considerations for the DDM, specially for stainless steel. This research project will develop the bases for the system-based New Generation Design Methods for stainless steel structures, and this fellowship will provide a most adequate training in structural reliability for the development of the pioneering DDM for stainless steel structures and the corresponding design recommendations for their inclusion in the Next Generation European Standards. It will be an international and inter-sectorial effort to provide designers with powerf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Laser assisted chemical micro-machining and replication' (LAMAR), addressing dissemination and exploitation.

assistant: **Impact**

The aim of this project is to develop a novel rapid prototyping and production route for MEMS components. LAMAR will develop laser induced chemical etching and micro-moulding techniques that will be used to produce microstructures with high, and well defined aspect ratios in a wide range of material systems including polymers, metals and glasses. Two rapid prototyping routes will be explored: gas phase laser induced chemical etching and liquid phase laser induced chemical etching. In addition, novel micro-replication techniques will be developed in order to produce large quantities of component in a cost effective process from the laser produced masters. The laser prototyping system will be optimised for the purpose of replication in order to address the problems of surface roughness and wall angle which nave significant impact in the de-moulding process.The industrial end-user materials of interest include metals (e.g. Ti Ni:Ti alloy), glasses and polymers. The project will implement the novel laser assisted processes on CAD/CAM compatible workstations for industrial use. The full rapid prototyping technology will be demonstrated by the fabrication of several demonstrator structures (micro-optics, electro-magnetic components, micro-grippers). The specific objectives of LAMAR are: - To develop industrial micro-machining processes to produce micron scale components with controlled wall angle (S to 10 degrees) - To develop laser assisted chemical etching processes that are applicable to a wide range of materials (e.g. metals, glasses, semiconductors, polymers) - To develop rapid laser assisted chemical etching techniques that give good surface finish (Ra < 1nm) - To develop a micro-replication technique for novel high aspect ratio (>50:1) structures - To improve laser ass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A DEMONSTRATION OF THE COMMERCIALISATION POTENTIAL (VALAR 2,5 MW)' in the context of a Fourth Framework call.

assistant: **Objectives**

To demonstrate that by combining two innovative techniques a 2.5 MW offshore wind farm can be constructed more economically than previously believed.The amount of installed effect of wind generation that an existing electrical grid can accept is often limited by the voltage quality requirements eg. 'flicker'. With the use of a new control system the windfarm can be connected to a weaker" transmission network.With this project we aim to demonstrate that with electronic control systems installed in 3 out of 5 WEC's in the wind fann the existing electrical grid can handle a generated output from the wind farm upto a value that is limited only by the thermal overload of the transmission cables. Thus the use of the electronic controllers reduces the requirement for expensive grid strengthening.The costs of the installation are also reduced through the use of rock-socketed monopile foundations constructed with the aid of a floating jack up barge. With this method the construction period and erection costs of the offshore installation at Bockstigen Valar can be substantially reduced compared with previous offshore installations. The aims with this project is also to provide better knowledge of:* offshore windresourcesand how offshore windpower influences* flora and fauna* the landscape picture* seafaring.The site of the project has an estimated mean annual windspeed of 8.0m/s and is on shallow ground in the Baltic sea approximately 4km from the coast of Gotland. The windfarm will consist of of 5 No.stall regulated WEC's type Wind World W-3700/500kW located 250 m apart in a V-formation. The estimated average annual output of the WEC's is 8000 MWh/yr. The WEC's will be specially modified to facilitate service and maintenance offshore. The modifications will involve providing spe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Mapping for Low Power'.

assistant: **Innovation**

The project will allow the continuation of cooperation started during the ESPRIT BRA LINK (6855) project on links between low-level and high-level synthesis, among three partners of this project: UCL and INPG from the EU and ICI from Moscow, RU.The three partners have already developed basic and efficient tools in digital logic synthesis. They were working together on low level synthesis CAD tools for logic synthesis, principally based on Boolean and BDD techniques. The research efforts will continue this action in the improvement of algorithms for low power efficient VLSI systems, principally in the context of the technology mapping.The main topics covered will be the enhancement of efficient decomposition techniques for low power, the development of new covering and matching algorithms, and critical path detection and remapping in close relation to place and route tools.All the efforts will lead to coherent CAD developments which will be tested on realistic system designs. The requested contribution is to help in regular contacts of ICI with the EU partners and to open ICI to the research community of the European Union countries. This will enable them to access and be trained to efficient CAD tools. Joint publications and presentations at international conferences and workshops are planned, and a final workshop on efficient low power VLSI systems will conclude the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nanoscopically-guided induction and expansion of regulatory hematopoietic cells to treat autoimmune and inflammatory processes', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

We propose a multidisciplinary program, focusing on the development of novel approaches for directing the differentiation, proliferation and tissue-tropism of specific hematopoietic lineages, using micro- and nano-fabricated cell chips. We will use advanced nanofabricated surfaces functionalized with specific biomolecules, and microfluidics cell chips to specify and expend regulatory immune cells for treating diverse inflammatory and autoimmune disorders in an organ- and antigen-specific manner. The proposed cell-chip will create ex-vivo microenvironments mimicking in-vivo cell-cell interactions and molecular signals involved in differentiation and proliferation of hematopoietic cells. Cell chip development and optimization will be supported by high throughput microscopy to select for optimal conditions. “Educated” cells will be employed for in vivo experiments in mice and the methodology will be further adapted for human cell populations, and applied for clinical diagnosis and therapy as well as the developments of clinically-relevant devices. Regulatory T-cells are extremely promising cells for treatment of inflammatory and auto-immune disease, as well as for tolerance induction in organ transplantation. To be effective they must be produced conveniently, at large numbers with an optimally tuned phenotype. The methodology is suggested to overcome current obstacles in obtaining therapeutically significant numbers of T cells. We propose to apply the suggested methodology for treating different inflammatory or autoimmune diseases including type-1 diabetes using targeted immunotherapeutic approaches. Developing new methods for producing large numbers of finely-tuned and tissue-targeted regulatory cells will make this approach clinically viable. This novel methodology can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Monitoring Compliance with EU Fisheries Regulations' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Specific Objectives:The main objective of the project is to improve compliance monitoring of EU fisheries by making it more effective and more efficient. Specific objectives are to:- develop and assess systems incorporating spaceborne synthetic aperture radar imagery for fisheries monitoring;- improve the monitoring capability of airborne surveillance by integrating information from other systems;- support the development of a harmonised electronic logbook meeting requirements for European catch, sales and landing reporting regulations;- contribute towards the development of an online database containing the genetic catalogue of European marine fishes; develop the European networks and critical mass in the field of vessel monitoring in order to integrate effort as a contribution to the European Research Area, with particular emphasis on the enlargement countries. Anticipated milestones and schedule: During the course of 2003 4 network meeting will be held (March, June, September and December) in order to progress the work. Two meetings will be held, one in February and one in September in order to define the Pilot Project. benchmarking studies will be undertaken throughout the year to determine the most appropriate algorithms for vesel detection and classification; based on the pilot project in electronic logbooks, a way forward will be proposed in December 2003. The prototype database for genetic characteristics will have been produced by December 2003.Planned Deliverables:By the end of the year the integration of passive synthetic aperture radar (SAR) data with the on-board Vessel Monitoring System will be at an advanced stage and the Fisheries Monitoring Centres will be receiving timely SAR images. Contributing to that deliverable will be the following: report on pil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A multi-disciplinary approach to the development of epitope-based vaccines' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The concept behind the proposal is the optimal design of anti-viral and anti-parasite vaccines. The strategy is to vaccinate with minimal structures consisting of rationally designed protective epitopes, adequately presented and easy to deliver, which are capable of stimulating effective B-cell, T-cell and cytotoxic immune responses whilst avoiding potentially hazardous and undesirable effects. The objective is to achieve vaccines which will be effective when delivered via the mucosal route and effective in the presence of maternal antibodies. The precise objective is to develop second generation vaccines that will be more efficient, more economical, safer and easier to deliver than currently available vaccines. This will be achieved by using synthetic peptides, mimotopes, retro-inverso peptides, synthetic recombinant constructs and DNA vaccines. Molecular modelling will be used for the design of epitopes with the maximum binding affinity for MHC molecules on antigen-presenting cells and for antibodies. The cumulative data will be analysed to identify the optimal procedure(s) to provide the most efficient vaccines against the viral, bacterial or parasitic diseases under study. The conclusions arising from the work will be applicable for the design of vaccines against other pathogens. Essentially all of the currently available vaccines are based on the use of inactivated or live-attenuated pathogens. However, these vaccines have several shortcomings, such as difficulties of in-vitro culturing, biohazard risks, as well as loss of efficacy due to the genetic variations seen in many viruses. These problems can be solved by the work proposed here since the use of synthetic materials for vaccine production (available in unlimited quantities and posing no biohazard) and the us