RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'GROWING CONNECTION FOR BIO ECOSYSTEMS' to be submitted under Horizon Europe.

assistant: **Abstract**

COBIOE is project to interconnect innovation ecosystems to foster 4.0 industrial transition in the biopharmaceutical deeptech sector, sharing competences, information and opportunities, with the aim of ultimately converging toward a common and inclusive European strategy for bioproduction support. Specifically, the proposition will focus on the bioproduction sector that includes development of small molecules, biologics, drugs, innovative therapeutics (such as gene and cellular therapies), high technology drugs based on cell and molecular biology, and covers various applications in health (oncology, immunology, virology, rare diseases, etc…).COBIOE will reach the following objectives:- Provide a state of the art and exploitable overview of the European bioproduction value chain, focusing on European, national, regional strategy or existing initiatives, activities- Opening up the bioproduction field, by reaching out to isolated actors and territories bringing added value to the chain.- Building up bridges between sparse innovative ecosystems and initiatives opening up opportunities for isolated players.- Promote bioproduction ecosystems, the field and its potentialities in terms of green, digital and social transition, among various stakeholders and policymakersCOBIOE proposal includes 5 health clusters/networks, preeminent and pioneers in the field of pharmaceutical biomanufacturing. Each partner complements each other in terms of competence and the partnership covers almost all European regions from north to south and east to west, including modest, moderate, strong and leading innovators. Moreover, each partner benefits from an extended network of stakeholders, from different technological sectors (materials science, artificial intelligence, biotechnology, blockchain,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Nuclear Pore Basket – Functional Architecture of a Membrane Remodeling Machine' in the context of a Horizon 2020 call.

assistant: **Objectives**

Nuclear pore complexes (NPCs) are gatekeepers at the nuclear envelope, mediating traffic between the nucleus and cytoplasm. Unlike simpler protein channels that insert into a single lipid bilayer, NPCs can remodel the outer and inner nuclear membranes to form a specialized pore in the nuclear envelope. High-resolution models of the symmetric NPC core have transformed our understanding of NPC architecture. In contrast, we know little about the NPC basket, a prominent structure on the nucleoplasmic side of NPCs. This lack of knowledge is salient, because the basket impacts on transport, DNA repair, and chromatin activity. Notably, the basket was recently found to play a key role in shaping the nuclear membrane, which is critical for NPC biogenesis. Studying the NPC basket is challenging because of its size, intricate architecture, structural flexibility and embedding in a membrane. Yet, knowledge of the architecture of the NPC basket is central to understanding how it influences gene expression, and operates in membrane remodeling in synergy with the NPC core. I propose to develop new experimental tools that will enable a structural analysis of the basket in its membrane environment. This will provide unprecedented insight into the function of this enigmatic part of the NPC.


**Keywords:** Nuclear Pore Complex, Nuclear Envelope, Biochemical Reconstitution, Membrane Biology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High Performance Computer and Quantum Simulator hybrid' in the context of a Horizon 2020 call.

assistant: **Objectives**

The aim of HPCQS is to prepare European research, industry and society for the use and federal operation of quantum computers and simulators. These are future computing technologies that are promising to overcome the most difficult computational challenges. HPCQS is developing the programming platform for the quantum simulator, which is based on the European ATOS Quantum Learning Machine (QLM), and the deep, low-latency integration into modular HPC systems based on ParTec’s European modular supercomputing concept. A twin pilot system, developed as a prototype by the European company Pasqal, will be implemented and integrated at CEA/TGCC (France) and FZJ/JSC (Germany), both hosts of European Tier-0 HPC systems. The pre-exascale sites BSC (Spain) and CINECA (Italy) as well as ICECH (Ireland) will be connected to the TGCC and JSC via the European data infrastructure FENIX. It is planned to offer quantum HPC hybrid resources to the public via the access channels of PRACE. To achieve these goals, HPCQS brings together leading quantum and supercomputer experts from science and industry, thus creating an incubator for practical quantum HPC hybrid computing that is unique in the world. The HPC-QS technology will be developed in a co-design process together with selected exemplary use cases from chemistry, physics, optimization and machine learning suitable for quantum HPC hybrid calculations. HPCQS fits squarely to the challenges and scope of the call by acquiring a quantum device with two times 100+ neutral atoms. HPCQS develops the connection between the classical supercomputer and the quantum simulator by deep integration in the modular supercomputing architecture and will provide cloud access and middleware for programming and execution of applications on the quantum simula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Understanding genetic control of global gene expression in human macrophages to discover new immune mechanisms protecting from tuberculosis' (TB-IMMUNOGEN).

assistant: **Innovation**

Tuberculosis (TB) is a major global problem that urgently requires new preventive and therapeutic approaches. Only minority of people infected with M. tuberculosis develops active TB. Genetic studies provide an unbiased way to scan the whole human genome to find sequence polymorphisms that predispose to TB. Therefore, we have established the world s largest sample collection for TB genetic studies. Now we genotype 6,000 HIV-negative patients with pulmonary TB and 6,000 healthy controls at ~1 million polymorphic sites across the whole genome. This genome-wide association study (GWAS) will allow us to compare frequency of genetic variants among patients and controls to find genes that protect from TB.Given that susceptibility to TB is a complex disease, a complementary strategy in genetic research is to identify variants that control intermediate cellular phenotypes. Here, for the first time I will undertake a large-scale study to identify polymorphisms that control gene expression in human macrophages, cells that play key role in protection from M. tuberculosis. We will study in vitro global gene expression in uninfected and M. tuberculosis-infected macrophages from hundreds of healthy volunteers correlating it with the genome-wide genotype data of these subjects. This will allow us to identify variants that regulate differential gene expression in macrophages upon M. tuberculosis infection. We will also study functional effects of the polymorphisms associated with TB risk in the previous and ongoing studies. Taken together these experiments will discover genes and biological pathways involved in protection from M. tuberculosis and will characterise macrophage transcription profile of subjects that are genetically predisposed to TB.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'HIGH RELIABILITY, LOW COST, STACKABLE POWER SUPPLY FOR SECURITY SYSTEMS' under Seventh Framework.

assistant: **Concept**

Security systems (including fire, intrusion, access control, and voice alarm) typically contain an AC-DC power supply to deliver power to the system and to charge and maintain 12V batteries, which provide the “secondary source” during a mains failure. The combined power supply-charger-battery system represents a key component of such systems in terms of cost and contribution to system reliability. For the SME manufacturer and installer, the manufacturing, inventory, document control, and service costs associated with the provision of a wide range of power supplies to address the market is significant. In addition, as amendments are made to the applicable EN standards (EN54-4/A2, EN50131-6, EN60849, etc) manufacturers are often required to re-design, re-test and re-certify each power supply design, which represents significant actual and opportunity costs. As such, SME consortium members have identified a need to address the costs associated with existing security system power supplies, and at the same time significantly improve the manufacturability, reliability and the feature set of these key components. The stackable (load sharing) approach offers increased reliability through design and redundancy and cooler operation by spreading component heat over a larger surface area. Manufacturing costs are minimized via the manufacture of high volumes of a common module to suit a wide product range, and the need for only one test fixture and test procedure. The approach also enables a given system to configured for a range of standby times (eg 24 to 72 hours) as required by the customer. SME participants plan integrate the SECURITAC power supply as a key component in their own products and installations, and to sell it to other manufacturers in the form of an OEM module.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Application of hard synchrotron radiation x-ray phase contrast imaging techniques to materials science' to be submitted under Fourth Framework.

assistant: **Abstract**

The small angular size of the X-ray sources at modern synchrotron radiation facilities like the ESRF imply a high spatial coherence of the photon beams. This was recently shown to make the imaging of phase objects through Fresnel diffraction straightforward, with a very simple experimental setup. This gives the possibility of imaging objects involving negligible absorption of hard X-rays but appreciable variations in optical path length due to thickness or compositional variations. This first experiments performed at the ESRF on organic (bones, plants) or inorganic (test materials with inclusions, holes, cracks) samples appear very promising. I intend 1) to further investigate the capabilities of this new technique, 2) to extend it to phase-contrast tomography, and 3) to apply these techniques to the investigation of the influence of precipitates and pores on the mechanical properties of industrial materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Impact of Research on EU Agriculture' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The project will:• describe the contemporary evolution of traditional public and private agricultural research, particularly as its boundaries with food processing, biotechnology and bioeconomy activities (for example, renewable energy) are becoming increasingly blurred, and its objectives are broadening, using on-going structured interaction with an expert stakeholder panel• survey the trends, sources and objectives of agricultural research in EU and EEA countries and Switzerland, providing a scoping survey which provides a preliminary view of the range and integration of activities, and to design a framework, compatible with the OECD Frascati manual, to assess the volume and effectiveness of research• carry out econometric analysis and input-output modelling on the effect of research on agricultural productivity, including lag modelling, as the call specifically requires this, but with a view to acknowledging the importance of additional objectives for research; limited to a small number of country studies, to include small, medium and large countries which also reflect geographic diversity• in a number of regional case studies, selected for agro-ecological (and possibly also socio-economic) diversity, investigate the overall causal framework of case-specific individual research-based innovations, using active searching for disconfirming evidence as a validation criterion• innovatively and effectively communicate the results of the major workpackages to national governments and other stakeholders, through a variety of dissemination channels (webinars, policy briefs, as well as traditional reports and conference presentations)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Device-Edge-Cloud Intelligent Collaboration framEwork' in the context of a Horizon Europe call.

assistant: **Objectives**

The cloud computing industry has grown massively over the last decade and with that new areas of application have arisen. Some areas require specialized hardware, which needs to be placed in locations close to the user. User requirements such as ultra-low latency, security and location awareness are becoming more and more common, for example, in Smart Cities, industrial automation and data analytics. Modern cloud applications have also become more complex as they usually run on a distributed computer system, split up into components that must run with high availability. Unifying such diverse systems into centrally controlled compute clusters and providing sophisticated scheduling decisions across them are two major challenges in this field. Scheduling decisions for a cluster consisting of cloud and edge nodes must consider unique characteristics such as variability in node and network capacity. The common solution for orchestrating large clusters is Kubernetes, however, it is designed for reliable homogeneous clusters. Many applications and extensions are available for Kubernetes. Unfortunately, none of them accounts for optimization of both performance and energy or addresses data and job locality.In DECICE, we develop an open and portable cloud management framework for automatic and adaptive optimization of applications by mapping jobs to the most suitable resources in a heterogeneous system landscape. By utilizing holistic monitoring, we construct a digital twin of the system that reflects on the original system. An AI-scheduler makes decisions on placement of job and data as well as conducting job rescheduling to adjust to system changes. A virtual training environment is provided that generates test data for training of ML-models and the exploration of what-if scen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The dynamics and consequences of institutions for collective action in pre-industrial Europe' (UNITEDWESTAND).

assistant: **Innovation**

Europe s economic development in the centuries leading up to the Industrial Revolution, continues to fascinate scholars. In recent debates, institutionalised forms of collective action have been put forward as a key feature of Europe s precocious development. This project examines that connection between institutions and economic development in detail. It also harks back to the origins of such institutions, teasing out the impact of changing family patterns that emerged in Western Europe in the Late Middle Ages, which are often described as the European Marriage Pattern . Together with such factors as the absence of a strong state, and a helpful legal framework, the weakening of family relations may have created opportunities for other, non-kin social organisations to emerge, explaining the strength of institutions for collective action in this part of the world. Interactions between economic growth, marriage patterns and collective action institutions will be examined on several levels. A European wide-analysis, using specific indicators for institutional development and demographic patterns, should help clarify our understanding of their temporal and geographical co-evolution. Regulations for several types of collective action institutions will be analysed for Western Europe and Southern Europe to study the impact of household constitution and marriage patterns on institutional arrangements. A third level of the project, to be subdivided in an urban and a rural study, will look into the application of such regulations in everyday practices, through the analysis of several case-studies of guilds, commons and beguinages in the Low Countries. Finally, a sub-project is will promote dissemination and exchange of the project s data among the wider academic community. Severa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'ARTificial Intelligence for Seasonal forecast of Temperature extremes' to be submitted under Horizon 2020.

assistant: **Abstract**

Seasonal Forecasts are critical tools for early-warning decision support systems, that can help reduce the related risk associated with hot or cold weather and other events that can strongly affect a multitude of socio-economic sectors. Recent advances in both statistical approaches and numerical modeling have improved the skill of Seasonal Forecasts. However, especially in mid-latitudes, they are still affected by large uncertainties that make their application often complicated.The ARTIST project aims at improving our knowledge of climate predictability at the seasonal time-scale, focusing on the role of unexplored drivers, to finally enhance the performance of current prediction systems. This effort is meant to reduce uncertainties and make forecasts efficiently usable by regional met-services and private bodies. A statistical/dynamical hybrid model will be designed through the synthesis of (a) a cutting-edge dynamical Seasonal Prediction System and (b) a statistical model based on advanced Machine Learning (ML) techniques. Such a hybrid approach may become critical to improve climate forecasts, because it combines the theoretical foundation and interpretability of physical modeling with the power of Artificial Intelligence (AI), that can reveal unknown or disregarded spatio-temporal features.ARTIST will focus on seasonal prediction of temperature hot/cold extremes in Europe, but its scalable nature can make it applicable across a wide range of variables and geographical areas. Besides the employment of AI, a strength of the action stands in the use of local land surface predictors to instruct the empirical model. The fellowship, which includes a variety of training activities, will be mainly conducted at the Barcelona Supercomputing Centre (Spain), a world-renowned
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Stem Cells and Cancer Stem Cells in Mouse Mammary Glands'.

assistant: **Innovation**

It is thought that, although cancer stem cells are a small minority in the tumor cell population, they can escape the toxicity of drugs used for treatment, as they are relatively quiescent, i.e. chemotherapy can lead effectively to remission, but not frequently to a cure. An important question that cannot be answered at present and should certainly be addressed is whether a therapeutic window can be identified from the differences between normal cells, including normal stem cells, and cancer stem cells. The proposed work is a first step towards addressing this crucial question by examining in the context of mouse models of mammary tumorigenesis the relationship between putative normal and cancer stem cells and comparing their expression profiles with a long-term goal of eventually identifying advantageous drug-targets for therapeutic intervention to treat breast cancer. The use of stemness signatures for treatment purposes may find additional applications in the cases of cancers at other anatomical sites.