RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of the analytical tools for functional proteomics' (1998-2002).

assistant: **Concept**

The major objective of this proposal is developing tools for functional proteomics for analysis of the structure and properties of the gene products of bacteria, yeasts , plants animals and human organisms . The approach is based on the patented (by Quattromed Ltd) method of epitop-tagging of the proteins of interest with the purpose of fast and reliable purification, identification and detection of interactions of protein of interest with other components of the cell. Availability of such methods is absolute prerequisite for developing new medicines for treatment of infectious, acquired and inherited diseases of humans , animals and plants. We plan to develop a large family of manufacturable products for research laboratories and food industry dealing with the study of the structure and function of different gene products. The long-term application of the technology is the development of the epitop-tagged sensor-molecules for reliable and efficient tracking of transgenes in GMO.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cell biology of myelin wrapping, plasticity and turnover' in the context of a Horizon 2020 call.

assistant: **Objectives**

The myelin sheath is a plasma membrane extension that is laid down in regular spaced segments along axons of the nervous system. In the central nervous system it is formed by oligodendrocytes that spirally wrap their plasma membrane around axons to generate a highly abundant, tightly packed stack of membranes with unique structural properties. Previously, myelin has been regarded as an inert and purely insulating membrane, but it now appears that myelin is metabolically active, providing metabolic support to the underlying axon and participating in information processing by modulating velocity and synchronicity of nerve impulses in neuronal networks. In addition, myelination is not limited to the period of early post-natal development, but continuous into adulthood where it appears to be regulated by neuronal stimuli. This paradigm shift should be fuelled by new knowledge about myelin biology. Here, we plan to fill this gap by addressing the molecular basis of myelin growth, plasticity and remodelling. We will determine the factors that determine whether and to what extent an axon will be myelinated or not, the forces that drive myelin around the axon, the structural basis of myelin plasticity and the mechanisms of myelin turnover in the adult. We will test the hypothesis that microglia actively participate in myelin turnover by taking up myelin fragments that pinch off from the myelin sheath. To realize these aims we plan to pursue an integrative and multidisciplinary approach by bringing together genetics, biochemistry, proteomics and imaging in various model systems. The innovation arises from the combination of high-resolution imaging with molecular approaches in different cell types to obtain a unifying mechanistic understanding of myelin formation, maintenance and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Network - integrity assessment of large concrete dams' (NW-IALAD) under Fifth Framework.

assistant: **Objectives**

The integrity and safety assessment of concrete dams plays an important role for the infrastructure of many EU states. The water reservoirs created by those dams are often considered as a potential hazard to the population. The safety of these important structures is of great concern to the owners, operators and engineers as well as to the public. This is the motivation to establish a thematic network, which brings together stakeholders to conduct a state of the art review on integrity and safety assessment tools for concrete dams. The aims of the network are to compare and critically review the current practice of dams calculation and safety assessment, to conduct a systematic comparison of enhanced models for the numerical simulation of the structural behaviour of concrete dams and to develop further plans and strategies for research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Creating building blocks for atomic-scale electronics' (ATRONICS) targeting Horizon 2020.

assistant: **Abstract**

Interfaces in oxide materials offer amazing opportunities for fundamental and applied research, giving a new dimension to functional properties, such as magnetism, multiferroicity and superconductivity. Ferroelectric domain walls recently emerged as a new type of interface, where the dynamic characteristics of ferroelectricity introduce the element of spatial mobility, allowing for the real-time adjustment of position, density and orientation of the walls. This mobility adds an additional degree of flexibility that enables domain walls to take an active role in future devices and hold great potential as functional 2D systems for electronics.Up to now, application concepts rely on injecting and deleting domain walls in micrometer-size devices to control electric conductivity. While this approach achieves a step beyond conventional interfaces by utilizing the wall mobility, it does not break the mould of classical device architectures. Completely new strategies are required to functionalize the versatile electronic properties and atomic-scale feature size of ferroelectric domain walls. ATRONICS will establish a new conceptual approach for developing domain-wall-based technology. At the length scale of only a few atoms, we will use individual walls in improper ferroelectrics to emulate key electronic components such as diodes, transistors and logic gates. Crucially, as the functionality of the components is intrinsic to the domain walls, the walls themselves are the devices, instead of the previous approach of writing and erasing domain walls within a much larger classical device architecture. Beyond demonstrating individual devices, we will integrate multiple domain-wall devices, and develop quasi-2D circuitry and networks with a higher order of complexity then is current
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A nanotechnology-based approach for label-free single-cell analysis of cytoplasmic proteome' in the context of a Horizon 2020 call.

assistant: **Objectives**

Presently there is a strong need to single-cell tools able to provide new insights into cellular proteome heterogeneity underlying dynamics, mechanisms and cell states in development and disease. Of particular interest in this framework is the possibility to have an effective intra-cellular proteomic detection in live cells. This mainly for three reasons: the first relates to preservation of higher protein concentration if the detection occurs before a molecule is dispersed in the extracellular environment; the second reason stems from the need to study in greater detail and in real time, single cell processes such as the molecular cell cycle or the molecular fingerprint in a label-free way; the last reason came up from the universal necessity to know the intracellular concentrations of many molecules involved in pathological and not-pathological cellular processes. I hope to achieve the desired goal taking advantage of a scanning ion conductivity microscope (SICM) endowed with a chemically functionalised ultra-sharp nanopipette to visualise living cells highlighting, from the morphological and mechanical point of view, specific target cells, that would be further investigated in their molecular fingerprint piercing the cell membrane and performing a molecular immobilisation screening. For this purpose, the inner surface of the nanopipette will be coated with a self-assembled monolayer of antibodies to target the protein of interest. The interaction between the protein and the coating of the nanopipette would result in a variation in the ionic current flowing through the pipette due to aperture occlusion. Effective binding of the protein to the inner wall of the pipette will be detected and followed in real time and, after opportune nanoprobe calibration, intracellular
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Analysis of policy instruments and identification of tools for the implementation of rational energy use and renewable energy sources in Eu candidate countries' (EPA), addressing dissemination and exploitation.

assistant: **Impact**

The proposal objective is to identify and to generalize the best practices in energy-related policy concepts, the means to improve energy efficiency and increase the share of renewable energy sources in 8 EU candidate countries involved. Thus, all EU candidate countries shall be enabled to fulfil the EU accession conditions faster and easier.Upon accession, these countries will be in the position to considerably outbid the proposed commitments of the EU (12 per cent energy savings) and to double of the share of renewable energy sources by 2010 through a reduction in high energy intensity. Thus, the overly disproportionate participation of present EU candidate countries can help to stabilize the compliance of the Kyoto commitments by the EU, similar to eastern Germany's contribution in meeting the goals of unified Germany.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sound insulation prediction and optimization' (SOPRANO).

assistant: **Innovation**

With urbanization accelerating on a global scale, airborne and impact sound insulation have become key performance quantities of building elements. Unfortunately, acoustic requirements do not naturally align with structural and thermal requirements. Achieving good sound insulation is difficult, especially for innovative, more sustainable building systems which are typically lightweight. There is an urgent need in the construction sector for adequate sound insulation design prediction software. In the ERC Starting Grant VirBAcous, new, dedicated numerical methods for sound insulation prediction have been developed that possess the required combination of a high prediction accuracy and a high computational efficiency. By doing so, they open up the possibility of reliable model-based design optimization. The aim of this ERC Proof of Concept project is to bridge the gap between the fundamental numerical methods from VirBAcous and the construction sector.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Design of novel Magnetic Graphene Oxide Nanozyme platform for Theranostic applications'.

assistant: **Concept**

MagGraphZyme aims at the development of a new hybrid multiplatform capable of triggering the intracellular production of reactive oxygen/nitrogen species (ROS/RNS) for inducing cell death in cancer cells. The proposed hybrid nanosystem, based on the combination of magnetic nanoparticles (MNPs), nitrogen doped graphene oxide (N-GO) and a polymer (PLGA) shell, will improve ROS/RNS production due to the synergistic effects of all components regarding their catalytic activity as peroxidase-mimetic nanozymes. The control of this catalytic activity will be performed by heating the intracellular level via the activation of the constituent MNPs through a remotely applied magnetic field. Thus, a novel approach for intracellular ROS/RNS production and quantification will be implemented. Furthermore, with the aim of understanding the different cells’ pathways involved in the toxicity and the final death of the cells, these hybrid system will be evaluated to investigate pathway-specific ROS/RNS induction of apoptosis and ROS-response mechanisms. Thus, I will study signaling pathways which are known to be influenced by the production of these species. To this end, I propose detailed physical and chemical studies, down to the atomic level, of the MNPs@N-GO-PLGA systems for identifying the relationships between catalytic efficacy and active atomic sites within the structures. These works will be developed by a motivated researcher with a strong background in MNPs, who will enhance and diversify his skills in advanced microscopy techniques and will acquire competences in bio-medicine. This multidisciplinary and innovative proposal will strengthen the collaboration between the hosting institutions, will enable the European hosting institution to reinforce crucial competences in the unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Approximate Inference in Probabilistic Models' (INFPROBMOD) under Seventh Framework.

assistant: **Objectives**

We propose to develop and analyze approximate inference methods for probabilistic models. Probabilistic models are widely used in Machine Learning to solve complex real-world problems and they also form an important research area in Statistics. One of the biggest challenges in probabilistic modelling is to be able to infer marginal probabilities of some random variables in the model, a task which is often formally computationally intractable due to the complexity of the situation modeled. We propose to contribute to the advancement in developing and understanding the properties of approximate inference techniques through three important research objectives. The first objective is to develop and analyze approximate inference techniques for Bayesian Linear Gaussian State-Space based Models (LGSSMs). LGSSMs are used in many application domains and we recently developed a Bayesian approach to a class of models based on LGSSMs using a deterministic approximation technique. We would like to investigate more in dept the properties of the proposed technique and develop other approximation techniques which have different characteristics. The second objective is to perform a theoretical evaluation and a more exhaustive experimental comparison of the the state-of-the-art algorithm for approximate inference in LGSSMs with switching dynamics, and investigate the extension of this approximation technique to other related models. The third objective is to develop inference methods in sequential decision theory, by exploiting the new point-of-view which sees planning problems as inference problems in probabilistic models. We would like to concentrate on Markovian models not yet analyzed, and to apply the resulting methods to solve imitation problems in robotics and to design optimal se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Non-equilibrium dynamics of soft and active matter' to be submitted under Seventh Framework.

assistant: **Abstract**

**The joint exchange programme “Non-equilibrium dynamics of soft and active matter” (SoftActive) aims at bringing closer communities of physicists working at the forefront of statistical/nonlinear physics of out-of-equilibrium systems. Although many aspects of this very wide topic will be covered, the project is centered on the dynamics and fluctuations in soft and active matter, a subject of crucial importance in quantitative biology/biophysics.**The three countries involved, France, Germany, and Japan, and indeed almost all the participants of SoftActive, have a long history of collaboration on these topics, which are well-developed in each country. But these past and present collaborations have remained, so far, mostly bilateral, and it has become clear that further integration is needed.In particular, the groups involved in this proposal are leaders of the emerging field of ""active matter"" which is so far particularly well represented in France, Germany, and Japan. It is now time to structure international ties, which will strengthen the quality of research and allow for a rapid and organized growth.**The SoftActive project mirrors the “Dynamics of Nonequilibrium Soft and Active Matter” project just approved recently within the “Core-to-Core” program of the Japanese Society for the Promotion of Science (JSPS). It is divided into four main scientific topics, in parallel to the JSPS-funded Core-to-Core project:-Nonlinear response and non-equilibrium dynamics of liquid crystals and related problems-Slow dynamics of colloids and related problems-Dynamics and fluctuations far from equilibrium-Dynamics of active soft matter**The scientific goals will be reached via the exchange of researchers, notably young ones for long-enough periods of time to insure efficient transf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Software defined networking architecture augmented with Artificial Intelligence to improve aeronautical communications performance, security and efficiency' to be submitted under Horizon 2020.

assistant: **Abstract**

The SINAPSE project aims at proposing an intelligent and secured aeronautical datalink communications network architecture design based on the Software Defined Networking (SDN) architecture model augmented with Artificial Intelligence (AI) to predict and prevent safety services outages, to optimize available network resources and to implement cybersecurity functions protecting the network against digital attacks


**Keywords:** Datalink, Artificial Intelligence, Machine Learning, SDN, Intelligent Network, Performance, Capacity, Resource Optimization, Cyber Security
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Energy Efficiency Complaint Products 2014' (EEPLIANT).

assistant: **Concept**

The objective of EEPLIANT 2014 (Energy Efficiency Compliant Products 2014) is to help deliver the intended economic and environmental benefits of the Ecodesign Directive 2009/125/EC and the Energy Labelling Directive 2010/30/EU by strengthening market surveillance and increasing compliance with the Directives and the relevant implementing measures. EEPLIANT 2014 will achieve this by:-Implementing systems that coordinate, in the most cost-effective manner, the monitoring, verification and enforcement of ecodesign and energy labelling requirements across the European Single Market; -Increasing the adoption of best practice amongst Market Surveillance Authorities (MSAs).The Consortium (13 MSAs and PROSAFE) will design, carry out and evaluate coordinated market surveillance actions across three different product sectors over the next two years. It will deliver a higher level of surveillance activities that go beyond testing and will target products that represent the highest energy saving potential. The consortium will work closely with other non-participating MSAs across the EEA through its liaison with the Energy Labelling and the Ecodesign ADCOs. Additionally, the Consortium will work together with a Steering Board comprising of business, consumer organisations and environmental NGOs to draw on their knowledge and experience and to communicate through them with all stakeholders about the progress and results of the project. The expected results are:-Adoption by Member States of best practices on how to conduct market surveillance most effectively.-Greater compliance due to increased market surveillance of products in the EEA with the Implementing Measures of the Energy Labelling and Ecodesign Directives.-Increased awareness of (and respect for) market surveillance by ind