RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'ACTive flow control for aeroengine turbine efficiency increase in REAL stage conditions'.

assistant: **Innovation**

ACTREAL aims to deliver aerodynamics research enabling aeroengine turbine efficiency increase in order to reduce  greenhouse gas emissions.The aerodynamic loss in low-pressure turbines are largely accountable to flow separation in cruise conditions, the situation being more critical with nowadays ultra-high-lift blade design trends, hence increasing fuel consumption rates, thus emissions.  Active flow control is a promising technology to suppress separation thus reducing losses, which has been demonstrated effective but still some open questions hamper its industrial application in turbomachinery.This project aims to contribute to the likelihood of extensive adoption by considering real machine effects on flow active control which have not been yet investigated. The main objective of the project is to verify the effectiveness of active flow control and optimize control parameters for UHL LPT efficiency  increase in real stage environment.Real machine effects must be estimated as rotor-stator interaction, radial cascade, proper periodicity and compressibility through experimental campaign -in the third country organization linear cascade wind tunnel-  supported by numerical simulations by computational fluid dynamics tools. In facing this, assessment of numerical and experimental methodologies suitable for active control is carried out.Deep knowledge of fluid dynamics mechanisms of separation control in this environment are pursued by experiments and  high accuracy numerical simulations as Large-Eddy-Simulation. A preliminary study of a feasible mechanical technology to engineer active control without the use of electronic equipmenta will be undertaken.The contribution to EU scientific and technological knowledge and researcher training will be enhanced by taking advanta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Dynamics of Lie group actions on parameter spaces'.

assistant: **Innovation**

There are many parallels between Lie group actions on homogeneous spaces and the action of $\SL_2(\R)$ and its subgroups on strata of translation or half-translation surfaces. I propose to investigate these two spaces in parallel, focusing on the dynamicalbehavior, and more specifically, the description of orbit-closures.I intend to utilize existing and emerging measure rigidity results, and to develop new topologicalapproaches. These should also shed light on the geometry and topology of the spaces. I propose to apply results concerning these spaces to the study of diophantine approximations (approximation on fractals), geometry of numbers (Minkowski's conjecture), interval exchanges, and rational billiards.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Interruption of protein-protein interaction and network to cancer biomarkers and therapeutic targets' (PPI-MARKER).

assistant: **Concept**

Protein-protein interactions are keys to executing important cellular functions. We hypothesize that gain or loss of protein-protein interactions plays important roles in carcinogenesis. We propose a network-based approach to biomarker discovery that uses protein-protein interactions and regulatory transcriptional networks. We will use prostate cancer and gliomas as models. Prostate cancer is the most common form of cancer and the leading cause of cancer death among men in the developed countries. Glioblastoma multiforme (GBM) is the most common and most aggressive type of primary brain tumor and it GBM accounts for 52% of all primary brain tumor cases. Novel markers and therapeutic targets are still needed for these two cancers. We will be focusing on the androgen receptor protein-protein network in prostate cancer and TGF-beta mediated network in gliomas. Protein interactions will be extracted by text mining, from databases, and from structural data on protein complexes. To identify transcription factors and their targets in human, ChIP-Chip and ChIP-Seq experiments will be carried out. The resulting networks serve as a scaffold on which data of deregulated proteins derived from microarray and next-generation sequencing of patient cancer samples will be mapped. The perturbed subnetwork will be visualized with a new method that identifies and highlights network motifs and modules. Promising biomarker candidates will be further examined and validated experimentally. Where possible, candidates will be modelled using protein structural data on protein-protein complexes, providing the basis to design ligands that occupy binding sites in order to disrupt cancer-relevant interactions. Our proposal is highly innovative. We expect to identify key nodal points in the network, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Actin-based motility of intracellular human pathogens'.

assistant: **Innovation**

Actin and its associated regulatory proteins are fundamental components of the cytoskeleton, playing a central role in nearly every process in eukaryotes. Remarkably, the intracellular pathogens Shigella and Listeria have evolved specialized proteins, known as effectors, to hijack this crucial system of the host. These effectors induce actin polymerization on the bacterial surface, allowing the pathogens to propel themselves within and between host cells through a process called actin-based motility (ABM). Despite the critical role of ABM in bacterial infections, the mechanism by which ABM effectors interact with and activate host cell proteins is not understood at the atomic level. In addition, the regulation mechanisms of ABM and the host cell response to the cytoskeletal manipulation remain unclear.I therefore propose to elucidate the mechanisms of actin regulation during intoxication by ABM effectors. Using single-particle cryo-EM and cryo-electron tomography — techniques that have only become widely accessible in the past decade — I will determine the first high-resolution structures of ABM effectors and their complexes with actin-regulatory proteins. Building on my extensive expertise in studying actin and its associated proteins with these cutting-edge methods, I will develop a detailed mechanistic model of how ABM effectors orchestrate and regulate the host cytoskeleton, as well as how host cell proteins influence ABM within the cellular environment. Hypothesizing that cytoskeletal modulation by ABM effectors triggers cellular responses, I will employ a combination of proteomics and transcriptomics analyses to decipher how this manipulation of the actin cytoskeleton impacts host cell response pathways.This study will provide atomic-level insights into actin cyto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Optical Coding System of the Information Channel' (OCSIC).

assistant: **Innovation**

The overall objective of the project OCSIC - the Optical Coding System of the Information Channel is to verify technological and economic feasibility of a completely new technology for effective protection of the integrity and reliability of data transmitted by optical fibers through the use of information coding in the phase and polarization of light pulses in the physical layer of the fiber.Nowadays, millions of kilometers of fiber optic cables are spanning across the world, carrying incredible amount of critical financial, governmental, defense, medical as well as personal information. Deploying fiber optic cables in itself is extremely expensive, and investing further in the security of these cables (via area surveillance and mechanical access control, fencing, CCTV monitoring etc.) increases the overall cost to a great extent. Developing intelligent physical layer fiber security solutions at affordable price is therefore an imperative trend and an urgent market need.ZAZ innovation is exactly such an intelligent solution providing high level of data protection (which with current level of computer technology cannot be desyphred in less than 20 years), optical fiber interruption monitoring, detection of violation location with high accuracy (20 m), fast data transfer with easy installation – all of this at as little as 30% of the price of other (market state-of-the-art) solutions. The solution is dedicated to the military, governmetal, financial, and critical infrastructure sectors in EU and NATO countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Solute carrier proteins and the uptake of cytotoxic approved drugs' under Horizon 2020.

assistant: **Concept**

The transport of nutrients and metabolites across lipid membranes is a critical and essential biological process in both normal and pathological conditions. Specialized integral membrane proteins known as transporters are responsible for the movement of virtually any known class of biologically active molecules across membranes. Perhaps not surprisingly, there is increasing evidence that many drugs in clinical use also employ carried-mediated transport as the predominant entry method into the cell. Understanding the molecular and physiological basis of transporter-mediated drug uptake is therefore a key step toward the development of improved pharmacokinetics and models of toxicity for current and future therapeutically active compounds. We hypothesize that most approved drugs may require specific members of the solute carrier (SLC) family to cross the cell membrane, a phenomenon that would directly affect the compound activity, and that this process is basically underestimated in its importance. To test this hypothesis, the study proposed here aims at identifying SLC transporters involved in the uptake of a well-characterized set of commercialized drugs. The CeMM Library Of Unique Drugs (CLOUD) is a library of 300 compounds selected to be representative of the chemical space covered by all commercially available drugs. Human cell lines carrying deletions on specific SLC proteins will be tested for their ability to resist toxicity or challenges due to CLOUD compounds, allowing us to determine which transporter or family of transporters are involved in the uptake of specific drugs classes. The information derived from these studies will represent an important step forward toward a systematic characterization of the role of carrier-mediated transport in drug uptake.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Turning food industry's organic wastw into value' to be submitted under Horizon 2020.

assistant: **Abstract**

HOMEBIOGAS LTD develops and markets advanced biogas systems that reduce our clients’ waste management fees, energy expenses and environmental footprint by converting organic waste into biogas, a clean energy source. Since 2016, we commercialise HOMEBIOGAS TG1, an advanced, cost-effective household biogas system. So far we have sold more than 540 units in 46 countries, generating over €400,000 in revenues. We have been financed by private investors (€2.5 million) and government funding (€700,000) while a successful crowdfunding campaign has demonstrated an ample public interest in our products by collecting 219% of the targeted funding. We participate as editors of the ISO TC255/WG3 Domestic Biogas International Standard. There are more than 2.32 million food service and retail businesses in the EU, which annually generate over 15 million tonnes of food and kitchen waste . Waste management carries significant costs for them while public concern on the environmental impact generated by unsustainable waste management practices is growing. We aim to leverage the success of our household systems by offering these companies an affordable (€10,000), high performance biogas solution to fulfil their specific necessities:  HOMEBIOGAS TG6 will convert their organic waste (100 kg per day) into free clean energy (120 kWh per day), generating important savings (over €5,000 per year) and improving their environmental footprint and corporate image. HOMEBIOGAS TG6 has been demonstrated at TRL6 through the successful development and commercialisation of our TG1 system and the development and trial of two different large (200-250 kg per day) business-to-business pilots. Thanks to HOMEBIOGAS TG6, we will increase our profit by €31.7 million and hire 36 new employees by 2023.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Postharvest 2000' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Scientific research in the field of post-harvest handling of fresh agricultural plant produce is the basis for the development of the international trade in fruits, vegetables and flowers. This high level Scientists Conference is part of the series of International conferences on this area held every 4 years and which began in 1988 in Belgium. Its objective is to bring to the scientific community the advances that have been made in basic and applied research in the field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Learning from Massive, Incompletely annotated, and Structured Data' under Seventh Framework.

assistant: **Concept**

The need for machine learning (ML) and data mining (DM) is ever growing due to the increased pervasiveness of data analysis tasks in almost every area of life, including business, science and technology. Not only is the pervasiveness of data analysis tasks increasing, but so is their complexity. We are increasingly often facing predictive modelling tasks involving one or several of the following complexity aspects: (a)structured data as input or output of the prediction process, (b)very large/massive datasets, with many examples and/or many input/output dimensions, where data may be streaming at high rates, (c)incompletely/partially labelled data, and (d)data placed in a spatio-temporal or network context. Each of these is a major challenge to current ML/DM approaches and is the central topic of active research in areas such as structured-output prediction, mining data streams, semi-supervised learning, and mining network data. The simultaneous presence of several of them is a much harder, currently insurmountable, challenge and severely limits the applicability of ML/DM approaches.The proposed project will develop predictive modelling methods capable of simultaneously addressing several (ultimately all) of the above complexity aspects. In the most complex case, the methods would be able to address massive sets of network data incompletely labelled with structured outputs. We will develop the foundations (basic concepts and notions) for and the methodology (design and implementation of algorithms) of such approaches. We will demonstrate the potential and utility of the methods on showcase problems from a diverse set of application areas (molecular biology, sensor networks, mutimedia, and social networks). Some of these applications, such as relating the composition of m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Improvement of Foot and Mouth disease control by ehtically acceptable methods based on scientifically validated assays and new knowledge on FMD vaccines, including the impact of vaccination' (2002-2006) under Sixth Framework.

assistant: **Objectives**

There is a strong desire to reduce reliance on large-scale culling of animals to control future outbreaks of FMD in EU Member States. As an alternative, it is proposed to use emergency vaccination and then to screen for residual infection using tests for antibodies to the non-structural proteins of FMD virus. It is intended to amend the policy on FMD control to enable such an approach to be used in the very near future. In reality, this means that current contingencies must be based on the use of existing vaccines. Therefore, this project seeks to address the specific gaps in our knowledge and technological ability with respect to implementation of a vaccinate-to-live policy. The availability of adequate discriminatory diagnostic tests is the keystone of the new EU FMD control policy. The project is focused on the validation of NSP-based tests to discriminate unequivocally between infected and vaccinated animals, in order to allow the implementation of the new policy in the immediate term. Validation of existing and new NSP tests as confirmatory tests will be a major output of this project. The experimental design will also provide expected outputs in the field of the impact of vaccination on the carrier state and on virus dissemination, the onset of vaccinal protection, vaccine potency in relation to emergency use, vaccine strain selection and new marker vaccines. This project focuses on marker vaccines to induce durable protection against FMD. Conventional and marker vaccines will be targeted to dendritic cells with particular attention to promote dendritic cell mucosal homing (from parental immunisation), because mucosal immunity can prevent FMD virus establishing local infection and the carrier status.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quaternary Amino Acids on Scale for Medicine and Agroscience' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Enantiopure quaternary amino acids, carrying two carbon-based substituents at the α carbon, are one of the most important groups of modified α amino acids, of great commercial value in the development of new pharmaceuticals and agrochemicals. Certain of these quaternary amino acids are readily available by stereoselective α alkylation of available amino acids, but not those functionalized by the addition of α-aryl groups. In this project, we propose to develop an industrially scalable, practical method for the synthesis of α-arylated quaternary amino acids in enantiomerically pure form by streamlining, optimization and scale-up of a reaction we discovered while working on the synthesis of quaternary amino acids as conformational controllers within an ERC-funded Advanced Grant. The method is operationally simple and employs only inexpensive commodity chemicals as precursors. It uses no chiral auxiliary or catalyst, and exploits both structure and stereochemistry of the starting amino acid to make the quaternary amino acids in enantiomerically pure form. It avoid the use of transition metals, freeing the method from the potential problems associated with their toxicity, cost and volatility of supply. The nearest competitive methods are either limited in scope to electron-deficient aryl rings, or they employ toxic and expensive transition metal catalysts. Interest in the method has been garnered from the fine chemical, pharmaceutical and agrochemical industry, but further work on scale-up and practical issues are needed for the technology to become industry-ready.In parallel with this main thrust of the project, we will carry out preliminary work on related chemistry, developing a new, simple route to analogues of arogenate into a practical method for the synthesis of a ne