RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Integrated Methods for Advanced Geothermal Exploration' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The IMAGE project will develop a reliable science based exploration and assessment method to ""IMAGE"" geothermal reservoirs using an interdisciplinary approach based on three general pillars:1 Understanding the processes and properties that control the spatial distribution of critical exploration parameters at European to local scales. The focus will be on prediction of temperatures, in-situ stresses, fracture permeability and  hazards  which can be deduced from field analogues, public datasets, predictive models and remote constraints. It provides rock property catalogues for 2 and 3.2 Improving well-established exploration techniques for imaging and detection beyond the current state of the art and testing of novel geological, geophysical and geochemical methods to provide reliable information on critical subsurface exploration parameters. Methods include a) geophysical techniques such as ambient seismic noise correlation and magnetotellurics with improved noise filtering, b) fibre-optic down-hole logging tools to assess subsurface structure, temperature and physical rock properties, and c) the development of new tracers and geothermometers.3 Demonstration of the added value of an integrated and multidisciplinary approach for site characterization and well-siting, based on conceptual advances, improved models/parameters and exploration techniques developed in 1 and 2. Further, it provides recommendations for a standardized European protocol for resource assessment and supporting models.The IMAGE consortium comprises the leading European geothermal research institutes and industry partners who will perform testing and validation of the new methods at existing geothermal sites owned by the industry partners, both in high temperature magmatic, including supercritical, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A translational approach evaluating novel strategies using chemotherapy to enhance immune-mediated anti-tumor activity' (2007-2013).

assistant: **Innovation**

A wealth of successful pre-clinical immunotherapy-based treatment protocols against cancer have been documented, yet only a limited number of clinical trials have proven to be successful. A common consensus among clinical and bench-side researchers is that a combination of several treatment modalities should be used to achieve complete tumor regression. In recent years, evidence that chemotherapy agents can be used to enhance immune-based therapies has emerged. The specific aims described below are designed to evaluate novel treatment modalities against cancer using chemotherapy agents that have the ability to sensitize tumors to both innate and adaptive anti-tumor immune responses. 1. Examine the effect of different chemotherapy agents in their ability to modify tumor susceptibility to autologous and allogeneic natural killer (NK) and T cell -mediated apoptosis in vitro. 2. In vivo confirmation and evaluation of selected agents in murine syngeneic and allogeneic hematopoietic stem cell transplantation (HCT) tumor models. The results of these studies will lay a foundation for NK cell-based and T cell-based therapies which could lead to more effective treatments for cancer patients. In addition to defining mechanisms how the various chemotherapy agents may influence NK or T cell anti-tumor responses, several subsidiary projects derived from this research will most likely develop.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'MRI based mapping of microscopic brain composition in a mouse model of Alzheimer’s disease' (2014-2020) under Horizon 2020.

assistant: **Objectives**

This project aims to establish a neuroimaging framework which informs about microscopic brain composition and apply it to study neurodegeneration in a genetic mouse model of Alzheimer’s disease (AD).      AD is the most common cause of dementia, characterized by progressive neurodegenerative changes leading to a gradual cognitive loss and memory impairment. Pathological changes in AD are characterized by the accumulation of proteins to form amyloid plaques and tau-tangles as well as by variations in microscopic brain composition such as cell body density, neurite density, axon and myelin morphology, which can precede macroscopic brain atrophy and clinical symptoms even by decades. Thus, developing imaging biomarkers which can inform about these changes throughout the brain is a crucial step for early diagnosis and a better understanding of the disease.     To achieve this goal, this proposal takes an interdisciplinary approach combining state-of-the-art magnetic resonance imaging (MRI) modalities and novel computational methods, and has the following objectives: 1. Develop and validate a neuroimaging framework which encompasses advanced diffusion MRI and multi-exponential T2 MRI to map microscopic brain composition (markers of soma size and density, neurite density, axon diameter and myelin fraction). Pre-clinical imaging will be performed both in-vivo and ex-vivo in wild type mice and compared with histological staining2. Apply this methodology to investigate the changes in microscopic brain composition with the progression of AD in the APP/PS1 transgenic mouse model which develops Aβ-plaques, mimicking the early disease stages.3. Study the association between neurodegeneration and the development of Aβ-plaques, that will be quantified based on both MR micro-imaging wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploring Transglutaminase 2 as a potential therapeutic target for diabetes-induced sexual dysfunction' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Diabetes impairs blood supply and disrupts the integrity of the nervous system in genital organs, leading to sexual dysfunction (SD) and genital tissue fibrosis in both sexes. SD is strongly correlated with depression, reduced social well-being, and a diminished quality of life. Current therapeutic options for SD are inadequate, have important side effects, and no effective treatments exist for vaginal/penile fibrosis, underscoring an urgent need for advanced mechanistic studies to identify new therapeutic targets and develop effective and safe treatments. Transglutaminase-2 (TG2) is a multifunctional enzyme that operates in two conformations: in its open conformation, it exerts transamidase activity, which has a pro-fibrotic effect; in its closed conformation, it regulates vascular tone. It has been reported that TG2 is involved in vascular dysfunction and fibrosis, and pharmacological inhibition of TG2 improves endothelial function and shows great promise for treating fibrotic diseases. However, its role in the pathophysiology of diabetes-induced SD (DISD) remains unexplored.We hypothesize that TG2 may play a crucial role in DISD and erectile tissue fibrosis. Promoting the closed conformation of TG2 with an allosteric reversible inhibitor could improve sexual function by enhancing vascular function and preventing fibrosis.We will test this hypothesis by investigating: i) TG2 expression/activity in primary fibroblasts isolated from healthy rat erectile tissues and the involvement of TG2 in the fibrotic process; ii) the acute effect of TG2 inhibition on sexual function in healthy rats; and iii) the role of TG2 and the therapeutic effect of allosteric TG2 inhibitors in the rat model of DISD and vaginal/penile fibrosis. Furthermore, our project will address a significant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sustainable Transformation Of Rural Communities via Technical, social and Organizational innovations' (STORCITO).

assistant: **Innovation**

The sustainability challenges faced by rural communities in the European Union (EU) are multi-faceted, and empowering these communities to address them is crucial to achieve climate neutrality by 2050, since one-third of the EU population resides in rural areas and these areas house critical ecosystems and natural resources. STORCITO is a 36-month project that will focus on fostering innovation in three key areas and major challenges of rural areas in Europe: (1) sustainable management of resources and wildfire prevention, (2) transition of citizens to sustainable energy systems and (3) achievement of an inclusive climate-neutral mobility. To enable successful customized innovations for each challenge, different rural ecosystems have been selected as representative scenarios in the four main pedo-climatic zones in Europe (Atlantic, Mediterranean, Continental and Boreal), matching selected rural communities with the biggest challenges in the area. By the end of the project, STORCITO will provide the following technical, social and organizational innovative solutions: (1) new tailor-made nature-based solutions (NBS) to avert wildfires, (2) new digital dashboard with updated fire indexes; (3) new on-demand climate-neutral mobility app for rural users; (4) new organizational support manual to enhance community-energy systems; (5) new CCUS informative app; (6) tailored training and educational materials for stakeholders and general public, (7) guidelines for reproducibility and (8) policy recommendations to local administrations and other relevant rural stakeholders. These innovations will be co-created with rural stakeholders to respond to their needs and examined for their feasibility and/or drawbacks in different biogeographical regions. STORCITO will create a holistic an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Quantitative characterization of cardiac tissue microstructure from Diffusion Tensor Imaging'.

assistant: **Concept**

Cardiac Ventricular Remodelling (VR), i.e. the alteration of tissue microstructure that is a hallmark of several cardiac diseases, can have profound effects on cardiac function. A novel imaging technique, Diffusion Tensor Imaging (DTI) offers the potential to quantify VR in vivo and could thus have a significant impact on the assessment and treatment of cardiac disease. This project proposes the development of advanced analytical tools to evaluate its usability in the quantitative characterization of cardiac microstructure. The tools developed will aim at a) providing a mathematical description of normality in cardiac microstructure; and b) analysing local variation as an alternative descriptor for remodelling. A combination of preclinical and clinical validation will be performed, with histological slices used as ground truth for the identification of microstructural features. Emphasis will be placed on the development and application of a rigorous mathematical framework for the processing of tensor fields, including the quantification of local differences between tensors and the construction of statistical models for the quantification of pathology.The project joins an early researcher with extensive expertise in the statistical analysis of manifold-value data and its uses in medical imaging with an internationally recognized group in the analysis of cardiac microstructure and its links to electromechanical function. The host group has a network of collaborators including all relevant areas, from MRI physics to cardiac physiology. The program also includes the provision of further training opportunities for the applicant in different aspects from student supervision to preparation of research proposals, representing a unique opportunity for his development as an indep
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The Challenge of Private Urban Governance and the Rise of Gated Communities in Europe'.

assistant: **Objectives**

The European metropolitan regions are facing with the new challenge of the emergence of private urban governance and the rise of gated communities. Despite of the growing number of case studies there is however a lack of comparative studies and of a general theory that could link the main research paradigms (the market-driven process approach conceptualise the rise of gated communities via economic rooted consumer-side choices, while the politics-driven process approach see it as results of exclusionary political behaviour of the affluent). The overall aim of the research project is to fill these gaps with a cross-European comparative study using an innovative research framework.  In order to analyse the driving economic, social, and political factors it will be gathered and evaluated a cross-European database about gated communities. To offer policy recommendations the research will use the framework of the trilemma of urban governance developed by the applicant. Its main message is that the objectives low congestion cost, high efficiency in production of public goods and services, and high social cohesion are mutually incompatible. Policymakers have to choose among these desirable elements; however they can have at most two out of these three at the same time, having to decide which one they wish to give up. The main objective of the career development of the applicant is his integration into the European scientific excellence networks. The applicant has a wide-range knowledge in economic geography and research experience in Central and Eastern Europe that is the main basis to carry out the proposed research project with high scientific quality. Because of the multidisciplinary feature of the research projects it is however also needed skills and expertise in urban pl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'East-West variations in north Atlantic impacts on ecosystem processes', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

RTD actions implementing ENRICH are part of accompanying measures of the Environment and Climate Programme, the Marine Science and Technology Programme and the International Cooperation Programme. CORDIS generally does not held information on accompanying measures of RTD programmes. Therefore for further details please contact: Ib Troen, European Commission, DGXII.D.I at ib.troen@ec.europa.eu.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Real-time optimal control of the CO2 heat pump system for residential use'.

assistant: **Concept**

The aim of this project is to develop efficient real-time optimal control (RTOC) for the carbon dioxide (CO2) heat pump as a part of a building energy supply system and validate its reliability experimentally. This is necessary to increase the system efficiency. For a high system efficiency with CO2 heat pumps for heating purpose, a low water return temperature from building heating systems is crucially important. However, this is still difficult to achieve due to well-established heating solutions and control strategies that are not suitable for CO2 heat pumps. CO2 is considered as one natural refrigerant, which has the merit of nonflammability, non-toxicity, and low price when compared with traditional refrigerants. Current well-functioning control methods are developed for heat pumps based on HFCs. Current RTOCs have the disadvantage of large computational load, which makes them difficult to operate with real building energy systems. Furthermore, experimental validations for the developed RTOC cannot be conducted due to lack of advanced experimental conditions. A reliable and experimental-validated RTOC for CO2 heat pump systems is urgently needed. This project will be developed by combining my scientific expertise on RTOCs with advanced experimental conditions with the CO2 heat pump for residential heating use at the host laboratory. Model-based predictive control (MPC) will be used to develop the RTOC. Machine learning methods will be used to develop the non-linear system model. Further, the RTOC with multiplexed optimization strategy (MOS) will be implemented in simulation environment. After the reliability of the developed RTOC in simulation environment is validated, the RTOC will be tested in experimental conditions. Finally, the reliability of the developed RTO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Ambient Assisted Living Innovation Alliance' (AALIANCE).

assistant: **Concept**

Subject of the Coordination Action AALIANCE will be Ambient Assisted Living (AAL) solutions based on advanced ICT technologies for the areas of aging at work, aging at homed and aging in the society. AALIANCE will- provide a framework for stakeholders, led by industry, to define research and development priorities, timeframes and action plans on strategically important issues in the field of Ambient Assisted Living- play a key role in ensuring an adequate focus of research funding for AAL, in fostering effective public-private partnerships and in developing a European research policy, in particular in focusing on FP7 and on current activities launched by EU member states (AAL 169).<br/>Therefore the immediate objectives of AALIANCE consist of:- setting-up a sustainable network - starting with 14 partners to be extended to approx. 35 - involving companies as technology providers and systems integrators, service providers, research organisations and user associations- coordinating the various activities of European industry and research institutions in the field of Ambient Assisted Living,- defining standardisation requirements- providing recommendations for a European RTD policy on Ambient Assisted Living, and- supporting European and national entities to increase political awareness and intensify activities for the enhancement of new AAL technologies.<br/>From these activities it is expected to strengthen the Ambient Assisted Living value chain in Europe, to reinforce the position of providers of Ambient Assisted Living solutions in Europe and address one of the most promising markets of industrialised countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Energy Efficiency and Risk Management in Public Buildings'.

assistant: **Innovation**

The overall objective of EnRiMa is to develop a decision-support system (DSS) for operators of energy-efficient buildings and spaces of public use. By providing integrated management of conflicting goals such as cost minimisation, meeting energy, efficiency, and emission-reduction requirements as well as risk management, the DSS will enable operators to improve building energy efficiency in the most cost-effective manner based on their tolerances for comfort and risk. The DSS will be seamlessly integrated with the existing ICT for controlling each site's energy sub-systems, thereby facilitating the operators' real-time on-site generation dispatch, off-site energy purchases from diverse sources, and open positions in energy markets. The DSS will also enable long-term planning aimed at increasing energy efficiency, specifically analysis of retrofits and/or expansion of on-site energy sub-systems, in order to meet forthcoming EU targets for reducing CO2 emissions. A laboratory facility in Bizkaia, Spain will serve to test the operation of the DSS, while a community centre in northern Spain and a college campus in Austria will be the venues for the validation exercise. These site tests will enable cost-benefit analyses along with policy lessons for potential users of the DSS via workshops so that they may be able to reduce energy consumption and CO2 emissions by up to 10% in certain cases and improve sub-system integration in line with EU targets. In conjunction with preliminary market analyses and an exploitation plan, the DSS will be ready to make a wide impact at the project's termination by leading to the opening of a market for ICT-based solutions for buildings.