RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'SPAtially-Controlled lIgand arraNGement by origami-based nanoprinters' (SPACING) targeting Horizon 2020.

assistant: **Abstract**

The key challenge of SPACING is to develop a beyond state-of-the-art technology to self-assemble pre-designed 3D ligand configurations with sub-nanometer precision (nanopatterning) onto colloidal nanoparticles (NPs). The proposed aqueous-based technology is aimed to develop artificial NP´s libraries with a pre-designed discrete number of ligands in any desired spatial arrangement (i.e., inspired by nature such as virus capsids), which so far has not been feasible by any method (in solution or otherwise).Within this project we will design and develop a versatile, reusable and user-friendly DNA origami-based tool (nanoprinters) for printing ligands onto NPs; the multifunctionality and robustness of the nanoprinters required for such purpose will involve a first stage concerning the fabrication of libraries of NPs (different size and shape), for which we will design and assemble the corresponding libraries of DNA-origamis having pre-designed voids (shape, size, 3D ligand “stamps”).In a second stage, as a proof of concept inspired by previous knowledge on specific receptor-mediated endocytotic pathways and virus-cell interactions, we will use the nanoprinters to fabricate a discrete number of NPs with specific ligand configurations (ligand ID, number, density and 3D arrangement). The trafficking behavior of these bio-inspired NPs within cells and tissue models, will serve us to correlate their potential escape from endosome (thereby avoiding lysosomal degradation as viruses do).While the overall mission behind this project is to build the foundation for a technological implementation of artificial NPs with pre-designed 3D ligand configurations, and their potential to escape lysosomal degradation as viruses do, the proposed demonstrations will contribute to advance future de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Experimental and theoretical analysis of protein folding. Application to the b1 domain of protein g' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of the proposed work is to study the folding of the B 1 domain of the immunoglobulin G binding protein from Streptococcus using a variety of experimental techniques, including stopped-flow, fluorescence, circular dicroism, urea, GuHCI and thermal denaturation, as well as site-directed mutagenesis. The B1 domain has the qualities to make it an ideal system for studying the folding process. Recently the E. coli strains super-expressing this domain have been designed by Dr. Serrano's group. This opens the possibility to start GB1 folding studies using all the techniques mentioned. In addition, we can introduce mutations into the domain surface to increase the stability of secondary structure elements. This influence can be a priori estimated by empirical algorithms developed by the group. It would be most interesting to compare the observed experimental energetic changes with those predicted by theoretical calculations in order to investigate whether it is possible to use these algorithms for a rational increase in protein stability. The increase in protein stability is a major goal in protein engineering because of its potential industrial and pharmacological applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European Robotics Challenges' (EuRoC) under Seventh Framework.

assistant: **Objectives**

The European manufacturing industry needs competitive solutions to keep global leadership in products and services. Exploiting synergies across application experts, technology suppliers, system integrators and service providers will speed up the process of bringing innovative technologies from research labs to industrial end-users. As an enabler in this context, the EuRoC initiative proposes to launch three industry-relevant challenges: 1) Reconfigurable Interactive Manufacturing Cell, 2) Shop Floor Logistics and Manipulation, 3) Plant Servicing and Inspection. It aims at sharpening the focus of European manufacturing through a number of application experiments, while adopting an innovative approach which ensures comparative performance evaluation. Each challenge is launched via an open call and is structured in 3 stages. 45 Contestants are selected using a challenge in a simulation environment: the low barrier of entry allows new players to compete with established robotics teams. Matching up the best Contestants with industrial end users, 15 Challenger teams are admitted to the second stage, where the typical team is formed by research experts, technology suppliers, system integrators, plus end users. Teams are required to benchmark use cases on standard robotic platforms empowered by this consortium. After a mid-term evaluation with public competition, the teams advance to showcasing the use case in a realistic environment. After an open judging process, 6 Challenge Finalists are admitted to run pilot experiments in a real environment at end-user sites to determine the final EuRoC Winner. A number of challenge advisors and independent experts decide about access to the subsequent stages. A challenge-based approach with multiple stages of increasing complexity and fin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Synthetic Metabolism in Plants: Elucidating Vinblastine Biosynthesis and Implementing Strategies to Overproduce Complex Plant Metabolites'.

assistant: **Concept**

Nature produces a spectacularly diverse array of complex molecules that are exploited for many applications. Elucidating the biosynthetic pathways that are used to construct these complex molecules allows implementation of metabolic engineering or synthetic biology strategies that can dramatically improve production levels of these compounds. Moreover, identifying the biosynthetic genes facilitates study of the unprecedented biochemistry harboured within these specialised metabolic pathways. Unfortunately, research progress in plant specialised metabolism has lagged, in large part due to the complexities of plant systems. This has hampered the application of state-of-the-art synthetic biology approaches that can exploit this rich metabolism. The availability of inexpensive sequence data makes this an outstanding time to revisit difficult questions in plant metabolism. My group has recently obtained RNA-seq data for 24 tissues for Catharanthus roseus, which produces vinblastine, an anti-cancer drug that is arguably one of the most complex natural products found in plants. Moreover, my group has recently pioneered the implementation of gene silencing technology in C. roseus, which provides, for the first time, the means to rapidly assess C. roseus gene function in planta. This ensures that we will have a reasonably high-throughput platform by which we can assess gene candidates identified by hierarchical clustering analysis. In Objective 1, we outline a plan to identify vinblastine biosynthetic gene candidates using our transcriptome data and then screen these candidates for function in planta. We also propose a series of in vitro assays by which to characterise promising gene candidates biochemically. In Objective 2, we propose to reconstitute portions of the vinblastine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Medical Devices Design in Cardiovascular Applications'.

assistant: **Concept**

We propose an innovative, multi-disciplinary and multi-centre Marie Curie Initial Training Network; “MeDDiCA” (Medical Devices Design in Cardiovascular Applications) focused on Cardiovascular Engineering and Medical Devices. MeDDiCA Early Stage Researchers will build a career in cardiovascular engineering founded on both “skills for life” (communication skills, research and project management, IP, patenting, entrepreneurship, etc.) and “academic and technical skills”. The ultimate aim of MeDDiCA is to form well-rounded individuals, unlocking their potential in order to give them tools to succeed in an extremely changing area. To achieve this, the training must complement the existing background of each researcher to produce researchers capable of approaching a wide range of cardiovascular engineering applications. MeDDiCA will raise the profile and improve the career prospects of researchers who are in the first five years of their careers by offering structured training in cardiovascular engineering as well as providing complementary skills (“skills for life”). The technical skills will be applied to the study of cardiovascular medical devices through individual research projects, employing research methods including multi-scale modelling, 3D numerical simulation, in-vitro and ex-vivo laboratory models and experimentation. A strong focus on clinical and industrial translation will provide a consistent training programme for MeDDiCA researchers. Valves and stents have been chosen as exemplar applications to focus the scientific effort of MeDDiCA. Critical to the success of this Marie Curie Initial Training Network is the engagement of both academic research groups and industry to develop a varied and complementary training programme encompassing different aspects of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Assessing and Consolidating Recent Advances on Freshwater Ecosystem Restoration' under Horizon Europe.

assistant: **Concept**

The alarming state of freshwater ecosystems today:  Freshwater ecosystems degraded due to barriers / other morphological changes; loss of wetlands / floodplains; over abstraction of surface / ground waters; land management that reduces infiltration / generates pollution!Millions of euros and hours in ecosystem restoration works have made improvements, yet not stemmed the tide of biodiversity loss. The overwhelming complexity and diversity of approaches, the sheer mass of sometimes contradictory data,  the frighteningly heavy toll that failures take on public perception of the potential for Europe to succeed, the lack of media understanding of the challenges and our potential to deal with them – all of these demand a multi-pronged, country-by country campaign to consolidate recent scientific advances and innovations and to train the media to communicate them and the evidence that Europe can indeed halt biodiversity loss. EcoAdvance will co-create, through broad consultations and crowdsourcing, a user-friendly Prone2Success Checklist cataloguing the climate, environmental, economic, scientific, technological and human factors, country by country, that can make a difference and how to duplicate them.  EcoAdvance will consolidate recent scientific advances, drive media messaging and put a persuasive human face on freshwater ecosystem restoration successes - all from the perspectives of the people who did them, pursued, supported, tested, modified, demonstrated or evaluated them. By identifying and showcasing successful people, science and solutions that are “bending the curve”, EcoAdvance will bring guidance from personal journeys to support current leaders, scientists and decisionmakers who face some of the same challenges and dilemmas the successful have already navigated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Slotted-Waveguide Antenna for 5G and 6G Wideband Communications' (SWAWCom), addressing dissemination and exploitation.

assistant: **Impact**

This project aims to develop an antenna technology for the new communication systems at millimetre-wave frequencies (over 60 GHz). The new technology must comply with all the requirements that these new systems need, such as low cost, small size, reconfigurability, etc., in a wider bandwidth than state-of-the-art solutions already proposed. The combination of all these factors at such a high frequency is a significant challenge for the antenna research community. Specifically, an antenna array with a large number of wideband slots and a low-complexity reconfigurability system made in waveguide technology is proposed.First, a wideband radiating element made in waveguide technology will be researched. The applicant and the beneficiary already have experience in wideband slot antennas, which combined with the extensive experience in waveguides and slots of the associated partner for the outgoing phases, assures success. Among techniques that allow the reduction of simulation times of the arrays with a large number of elements, finding an equivalent circuit for the proposed element can greatly help in the design and improvement of both the single element and the array as a whole and is another aim of this work. The proposed research also involves the design of the array architecture and feeding network. In this area, the project aims to obtain a new hybrid feeding technology based on subarrays that will be suitable for wideband applications and allows reconfigurability. Lastly, the project pursues to implement and experimentally characterize the proposed designs to verify the results and contribute to the further training of the candidate in fabrication and measurement techniques in the mm-wave band.The results of the project will contribute to improving the bitrate and red
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Global models describing isolated rotating bodies in equilibrium in Einstein's theory of gravity' (1994-1998).

assistant: **Innovation**

Research objectives and content The main objective of our research project is improving our understanding of selfgravitating isolated rotating objects in equilibrium within Einstein's theory of general relativity. Despite its theoretical and astrophysical importance and the considerable attention it has received, the description of rotating isolated objects together with the exterior gravitational field they create is still very poorly understood and not even a single explicit example is known. Our approach to the problem will be trying to comprehend the underlying mathematical formulation of the problem. In particlllar we will try first to obtain which conditions must be satisfied by an interior metric so that it is suitable to describe an isolated rotating body in equilibrium (which is equivalent to analyse the existence conditions for the exterior field) and second to find a constructive way of obtaining the exterior field from the boundary data on the limiting surface of the body. In order to do so we will try to link the multipole moment structure of the exterior field with surface integrals of the boundary data on the limit surface of the body imposed by the interior metric. By solving this problem we can then explicitly construct the candidate to exterior solution given the interior metric. The compatibility conditions on the interior metric so that it certainly describes an isolated object can then be found by analysing the matching conditions of the two spacetimes. Training content (objective, benefit and expected impact) My past research experience has been focused in various mathematical aspects of classical general relativity, some of which are closely related with those needed to to develop this project. However, the difficulty of the problem will surely de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Refugee Emergency: DEFining and Implementing Novel Evidence-based psychosocial interventions' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

RE-DEFINE aims to implement effective psychological interventions for preventing the onset of mental disorders in refugees and asylum seekers with psychological distress resettled in middle-income and high-income countries. RE-DEFINE is particularly relevant for the refugee crisis in Europe and in bordering countries (i.e., Turkey), as the progressive increase in refugees seeking asylum poses a significant challenge to the health systems’ capacity to adequately respond to the health needs of this population. The project focuses on adaptation, testing, and implementation of Self Help Plus (SH+), a novel trans-diagnostic self-help preventive psychosocial intervention specifically developed by the World Health Organization (WHO) to respond to humanitarian crises. The intervention will be delivered by non-specialists to groups of up to 30 participants at a time. The cost-effectiveness of SH+ will be tested in two large, multicentre, pragmatic randomised studies. One study will be conducted in Italy, Germany, Finland, Austria, and the UK (high-income countries), and a second study will be conducted in Turkey (middle-income country). The dissemination plan will include structured activities such as an Individual Participant Data (IPD) meta-analysis of all randomised data available on SH+, in order to identify specific predictors of intervention’s effects that will facilitate its uptake and long-term implementation in European and non-European countries.


**Keywords:** evidence based intervention, prevention, randomised controlled trial, implementation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Miniaturized Devices for Single-Atom Quantum Technologies' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

We propose to realize a new and fully integrated approach for the manipulation of single neutral atoms, which has the potential to transform the complex, room-sized, multi-million-euro experiments currently used to manipulate these atoms in academic laboratories, into user-friendly, economical and robust commercial devices the size of a shoebox. As a proof-of-principle application we propose to realize an integrated single photon source based on a single trapped atom, which has immediate commercial potential in quantum communication and computing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Integrating ecosystem function into river quality assessment and management'.

assistant: **Innovation**

The project sets out to elaborate a novel methodology for assessing the ecological status of European rivers in functional terms. This will be achieved by determining the performance of a key ecosystem-level process (litter decomposition). Field experiments on the effects of excessive nutrient loading (eutrophication) and modification of riparian vegetation will be carried out at 60-paired sites in ten Ecoregions. They will be complemented by experiments aiming at a mechanistic understanding of process alterations and a literature survey to synthesise available information on river functioning. The assessment tool will be built on this broad synthesis. Its developmental steps include the identification of a set of indicators and their critical thresholds, and definition of the technical specifications of standardised procedures. Results will be compared with those of standard biological assessment schemes. The tool will be elaborated by a mixed consortium of scientists and end-user representatives. It will be disseminated to the scientific community, water and environmental agencies, potential stakeholders, and interested parties.