RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Calibration of sensory testing of food contact materials - paper and board (CALIBSENSORY)'.

assistant: **Objectives**

The Council Directive (89/109/EEC) for food contact materials implies that materials must not transfer their constituents to foods in quantities which could bring about an unacceptable deterioration in organoleptic characteristics thereof. There is no European Standard for the assessment of whether the stipulations in the directive are fulfilled. Moreover, the paper and food industries need the sensory tests for quality assessments of produced or purchased materials and for trade specifications. The aim of this project is to establish a calibration procedure for sensory testing of paper and board materials The first step is to create formulas for calibration samples. The second step is to establish a training procedure for sensory panels on the use of these calibration samples. Finally, an intercomparison test is performed to determine the practical viability of the formulas and training procedure.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Targeting IGF-1 receptor in liver cancer with focus on its mechanistic role in transcription and its interaction with the cell cycle machinery' (IGF1RHC).

assistant: **Innovation**

The insulin-like growth factor-1 receptor (IGF-1R) is a cell surface receptor kinase being vastly expressed in malignant tissues and plays crucial roles in growth and survival of cancer cells. Targeting IGF-1R is pharmaceutically today a very attractive concept. Larsson’s group at KI has contributed extensively to the current knowledge about IGF-1R and demonstrated that the cyclolignan PPP inhibits IGF-1R signaling. An oral IGF-1R inhibitor of cyclolignan chemistry is presently studied in patients with advanced cancer. Recently, they found that IGF-1R is SUMOylated, translocated to the nucleus, where it affects transcription. This is a novel and original function for IGF-1R and one of the goals of this proposal is to further study whether it is limited to tumor cells. In such case, these findings will be a breakthrough and the foundation for further development of specific therapeutic targeting of cancer. Here we aim to study two mechanistic aspects of IGF-1R: (1) its role as a transcription factor in tumor cells, (2) its interaction with the cell cycle machinery, as ultimate regulators of cell division. Hepatocellular carcinoma (HCC) was chosen as it has a very poor prognosis and a high mortality due to absence of efficient treatments. It is one of Egypt’s national health priorities and its incidence is increasing in Europe. Three experimental models will be used : HCC cell lines in which SUMOylation, nuclear translocation of IGF-1R and, which genes it transcriptionally activates will be studied, We will induce HCC in knockout mice lacking Cdk2 and p27, generated by Aleem to study how IGF-1R interacts with loss of these cell cycle proteins, and how its inhibition by PPP affects development and progression of HCC. Mouse Embryo Fibroblasts isolated from these mice will a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Uncovering the Role of Cancer Associated Fibroblasts in Facilitating Breast Cancer Metastasis', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Mortality from breast cancer is almost exclusively a result of tumor metastasis. Since advanced metastatic cancers are usually fatal, understanding the biology of tumor metastasis is the most significant challenge in cancer research today. It has become clear that the microenvironment of tumors is crucial in supporting tumor growth. Nevertheless, the role of the metastatic microenvironment in facilitating metastatic colonization is largely unknown. We recently uncovered a novel role for Cancer-Associated Fibroblasts (CAFs) in mediating tumor-promoting inflammation. However, the role of CAFs in the formation of a permissive metastatic niche that enables the growth of disseminated tumor cells is unresolved. I propose to systematically investigate, for the first time, the molecular changes in CAFs that facilitate metastases formation, which may lead to the discovery of novel targets for cancer therapeutics. To achieve this goal, I will integrate tumor biology knowledge and the unique expertise of my lab: we will combine novel mouse models of spontaneous lung metastasis of breast cancer, imitating the clinical setting, with multi-transgenic reporter mice that enable origin tracing and unbiased analysis of fibroblast sub-populations. By performing a comprehensive molecular and functional characterization of fibroblast co-evolution during metastases formation and analysis of breast cancer patient cohorts, we will uncover the dynamic changes in CAFs at the metastatic niche, identify the origin of metastatic CAFs, and elucidate the signaling pathways that govern their functional role in breast cancer metastasis. Molecular understanding of the early stages of tumor metastasis is an essential prerequisite for the discovery of novel therapeutic targets. Achievement of the proposed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Computing the Face Syntax of Social Communication', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Social interactions are critical to all societies. One of the most powerful tools for social interaction is the face – a complex system comprising variations of movement (expressions), morphology (shape/structure) and complexion (color/texture). Consequently, the face can elicit myriad rapid social judgments (e.g. personality, emotion, group membership, age, health, social status) with significant consequences (e.g. sentencing/voting decisions, social isolation, job offers). Yet, little is known about how the complex, dynamic face transmits the myriad messages that regulate social interactions in different cultures, how these complex face signals map onto psychological processes (e.g. categorical/dimensional perception) or which signals facilitate or hinder cross-culture communication. This is largely due to fragmented research on social concepts (mental states, personality, emotions), face signals (morphology, movements, complexion) and culture, which, consequently, has overlooked a possible latent algebraic, syntactical structure to social face signals across cultures. My own work hints at such a structure. My ambitious program will unify these fragments to derive the first generative, algebraic and syntactical model of social face signals using innovative methods combining social/cultural psychology, 3D dynamic computer graphics, vision science psychophysical methods, and mathematical psychology. It will thus test and validate a new theoretical framework of social face signals that will unite both categorical/dimensional and universal/culture-specific accounts of social face perception. This framework is highly relevant in the context of globalization and cultural integration where social communication using virtual agents is integral to modern society. It is thus im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Centres of european scientific excellence in industrial-relevant research areas'.

assistant: **Concept**

The proposed project concerns the development, verification and analytical use of quantitative data and indicators to explore and establish the current relevance of European public sector research institutes and universities as sources of scientific knowledge for RTD in the corporate sector. The information is derived from: (1) research papers in the international journals, and (2) international patents. Analyses focus on the contribution of those organisation in selected scientific sub fields characterised by relatively high levels of corporate sector research or significant corporate interest in academic research, especially basic research. In- depth analyses deal with selected emerging research themes (hot topics") in those sub fields. Expert-verified results are used to identify and compare these (potential) European centres of scientific excellence."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'SCIENCE COMES TO TOWN – UNITED TOWNS IN SCIENCE'.

assistant: **Objectives**

Being the 1st edition of Science Comes To Town (SCTT), UNITES will offer an inspiring and entertaining programme with more than 1,000 activities, bringing together over 70 partners in the cities of Kiel, Brest and Split and their regions by connecting scientific institutions, innovation ecosystems and citizens across Europe. More than 20,000 scientists are available to the partners for the implementation of UNITES. The cities share a similar geographic position as the largest coastal cities of their countries, yet still only medium-sized, peripheral and distant from any large urban agglomerations. They are all vibrant and renowned university cities with excellent town-and-gown relations, enthusiastic about hosting large science outreach events, including national and international science competitions, and experienced in organising large public festivals attracting several millions of visitors. The common profile results in shared local societal challenges and in a distinctly European approach to finding solutions. They have long participated in EU’s biggest flagship initiatives like the EU Missions and the European Researchers’ Nights. However, what truly UNITES the cities is the European University Alliance SEA-EU, where they have built a transnational network of nine universities and their city administrations. Together with the SEA-EU satellite events, UNITES' sphere of activity stretches from the Arctic Ocean to the Mediterranean and will attract over 1.5 Mio visitors and raise awareness of SCTT among more than 25 Mio people. A well-planned marketing strategy will promote SCTT across Europe, supported by the international visibility of EUCYS and EU TalentOn. UNITES will carefully select locally relevant topics and incorporate existing and newly developed interactiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrating technological and social aspects of foresight in europe' (1998-2002).

assistant: **Concept**

Foresight is increasingly used at regional, national and European levels as a strategic policy and planning tool. There is a clear need for a greater contribution to Foresight from the social sciences but so far their contribution has been rather small. This Accompanying Measure will develop a strategic analysis of the evolution of Foresight-related initiatives throughout Europe, with a specific focus on the integration of social and scientific/technological aspects. This analysis will help to deliver more effective socio-economic contributions to Foresight-related RTDI policies in the context of the European Research Area and in the New Framework Research Programme. This project will emphasise the different perspectives of social and patellar scientists/researchers, industry, public/societal groups and policy makers in contributing to Foresight indict, life sciences and enviroment & planning.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'A Modular Nanosystems Platform for Advanced Cancer Management:  Nano-vehicles; Tumor Targeting and Penetration Agents; Molecular Imaging, Degradome based Therapy'.

assistant: **Objectives**

SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners’ expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or therapeutic application as defined by their active agent compositions. For diagnostics, superior tracers will be developed for molecular MR/PET and gamma camera imaging, enabling efficient diagnosis and guided surgery respectively. Novel functionalized nano-core systems will be conjugated with semi-confluent active shell layer. Three types of shell layers will be design: (1) novel iron oxide nanoparticles as advanced MRI contrast agents and/or (2) DOTA complexes for MRI (with Gd3+), or PET (with Ga-68), or gamma camera (with Ga-69); (3) Integrating within one tracer both iron oxide nanoparticles and DOTA-Ga-68 complexes for a sequential or simultaneous MR/PET imaging. For therapeutics, active nanosystems will be developed to deliver (1) therapeutic siRNAs or (2) anti-MP-inhibitory-scFVs. These non-classic anti-tumor drugs will be designed based on an extensive tumor degradome analysis for combining blockage of selective matrix MPs, thus preventing basic invasive and metastasis steps, with siRNA based neutralization of secondary molecular effects induced by the specific protease inhibition. Individualized degradome analysis will be developed for potential profiling of anti-MP and siRNAs based therapy per patient. To facilitate the above diagnostics and therapeutic effects, advanced tumor targeting and penetration active agents will be linked to nano-core functionalized groups, inc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Riding a ‘Trojan horse’ against cancer', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

New therapeutic approaches have led to significant improvements in cancer treatment, but none have been able to overcome the limited efficacy of solid tumor treatment due to poor tumor delivery and the presence of hypoxic tumor cells. Macrophages represent a promising vesicle to deliver cancer therapeutics to solid tumors as they are continuously recruited into the tumor mass, even the most hypoxic regions. Our pioneering research demonstrated that macrophages are able to take up ferritins loaded with anti-cancer drugs, creating Macrophage-Drug Conjugates (MDCs), and transfer these to cancer cells and kill them, a phenomenon we named TRAIN. In my ongoing ERC STARTING GRANT PROJECT ‘MCHAP’, we have proven that MDCs can be used as a ‘Trojan horse’ to efficiently deliver drugs directly to the cancer cells via TRAIN.Now we aim to turn the MDC technology into a COMMERCIAL and SOCIAL VALUE PROPOSITION by confirming our findings in a PDX model, which is crucial to raise interest of and establish a co-development (or licensing) deal with big pharma’s to realize commercialization and clinical uptake of our IP-protected MDC technology. During the ERC PoC project, we determine the optimal efficacy of MDC delivery, examine the concentration of the drug delivered to the tumor and other organs, validate the efficacy of MDC delivery in PDX mice after MDC treatment,and optimize our business case. This project will thus provide PROOF OF CONCEPT for the efficacy and pharmacokinetics of, and establish the viability, feasibility, commercialization and overall direction for our innovative MDC technology.This project will substantially contribute to bring our MDC technology to the market and in clinical practice, where our MDC technology has the promising potential to improve prognosis of ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Big Data for Catalysis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Catalysis is one of the scientific areas in which Europe has a leading position. The radical change in the use of rawmaterials from oil towards gas or biomass might compromise this position. Computational techniques have been identifiedas the third pillar in catalysis research and provide a great amount of data that can speed up the generation of new catalyticsystems through rational design. Industries are now starting to focus on the large amount of data published in the openliterature regarding mechanistic studies so that they can accelerate their discovering of new catalysts. However, theunstructured and unlinked nature of this information hinders a fast transference of published knowledge to the chemicalindustry. Our BigData4Cat proof of concept would generate a simple, unified platform: ioChem-BD, where all the dataregarding atomistic theoretical simulations in catalysis could be stored and retrieved in a structured manner. The platformwill highlight the links, establish the relationships between data from different sources, provide error bars, and allowinferring data from missing steps in complex reaction networks. Moreover, it will provide problem-targeted structureddatabases with data-mining options. The final goal to the project is to transfer the mature computational Chemistrymethodology and data into growing research strategies through the ioChem-BD platform. The goal of the proof-of-conceptwill be to store, structure and search the Catalysis Big Data resources in a sustainable manner that can be adapted todifferent problems at academic, editorial and industrial levels.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'INTELIGENT CITIES'.

assistant: **Innovation**

INTELCITIES aims to support achievement of the EU policy goal of the Knowledge Society" by 2010 through advancement of e-Governance at the city scale, focusing on a range of citizens' and business concerns about decision-making over regeneration and management of their local built environment. It addresses IST strategic objective 2.3.1.9 Networked Business and Governments: "Development of ICTs to support (urban) organisational networking, (urban re-development) process integration, and sharing of resources (through public-private partnerships)" by constructing a demonstration of an Integrated Open System City Platform. The objective of the IOSCP is an integrated citywide information system continuously accessible to all (planners, developers, politicians, designers, engineers, transport and utility service providers AND individual citizens) that will enable more inclusive decision-making and support more sustainable life-styles.The IP brings together a critical mass of 20 cities, led by Manchester and Siena with 20 ICT companies including Nokia, Microsoft and CISCO and 35 research groups to undertake prototype studies in a number of EU cities aimed at integrating a wide range of existing IST platforms and information systems. In addition to technical interoperability the project will also address the parallel challenges of ensuring stakeholder inclusion and capacity building within local government organisation transformation so that feasibility, functionality and usability of the IOSCP can be adequately demonstrated.The open systems architecture, relevant standards and underlying multidimensional databases will ensure flexibility and futurity of the "intelligent environments" being developed. It is anticipated that this will provide more agile governance to support rap