RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ceramic membranes for hydrogen separation' under Fifth Framework.

assistant: **Concept**

The project will focus on the development of a membrane/membrane module toolbox (containing silica, zirconium phosphate and high temperature proton conducting membranes) for hydrogen separation from various process streams in the (petro)chemical industry. The applications range from rather low temperature applications (150-400C, e.g. the water gas shift reaction) via medium temperatures (600C, steam reforming) to very high temperature applications (>800C, e.g. dehydrogenation reactions) and are of high interest to all industrial partners. The scientific prospects are the development of membranes that can work under harsh (e.g. high temperature, steam containing) environments. Membranes and membrane modules which can operate under these conditions are currently not available and technical progress in industry is hindered thereby.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Brainstem circuits supporting adaptive instinctive behaviours' (CoreInstincts).

assistant: **Innovation**

Instinctive behaviours that achieve defence, feeding, aggression and parental care have evolved across animal phyla to ensure survival without the need for learning. Contrary to common belief, instinctive behaviours are not ‘hard-wired’ reflexes, but can be flexible in both action selection and execution. They are modulated by internal states, such as stress, hunger or oestrous  cycle, and may undergo short- and long-lasting adaptations in order to accommodate environmental changes and individual needs. The aim of this proposal is to gain a mechanistic understanding of adaptive instinctive behaviour output within a quantitative neuroethological framework and by combining molecular, cellular and circuit-level approaches. I will focus on the vertebrate periaqueductal gray (PAG), an evolutionarily conserved brainstem region that plays a crucial role in the initiation and execution of virtually all instinctive behaviours. Despite this, a comprehensive analysis of the cellular and network properties of the PAG, and their behavioural correlates, is lacking. In addition to generating the first dataset of PAG network topology using high resolution in vitro anatomical and electrophysiological approaches, we will study its neural computations across multiple instinctive behaviours and during motivational conflict using neural activity recordings in freely behaving mice. Building on these results, we will test the role of neuromodulation in imparting flexibility to this circuit (and the selection of appropriate behaviours), focussing on naturally-occurring neuromodulatory changes during the oestrous  cycle. By establishing how the PAG – a critical circuit that closely precedes motor neuron recruitment – controls and imparts flexibility to instinctive behaviours, this proposal will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'MIcro KErneL virtualizAtioN for hiGh pErfOrmance cLOud and hpc systems' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

MIKELANGELO is a project, targeted to disrupt the core underlying technologies of Cloud computing, enabling even bigger uptake of Cloud computing, HPC in the Cloud and Big Data technologies under one umbrella. The vision of MIKELANGELO is to improve responsiveness, agility and security of the virtual infrastructure through packaged applications, using lean guest operating system OSv and superfast hypervisor SuperKVM. In short, the work will concentrate on improvement of virtual I/O in KVM, using additional virtio expertise, integrated with the light-weight operating system OSv and with enhanced Security. The HPC in the Cloud focus will be provided through involvement of a large HPC centre, with the ability and business need to cloudify their HPC business. The Consortium consists of hand-picked experts (e.g., the original creator of KVM - Avi Kivity) who participate in the overall effort to reduce one of the last performance hurdles in the virtualisation (I/O). Other layers of inefficiency are addressed through OSv (thin operating system) and all packaged under the OpenStack or OpenNebula. Such approach will allow for use of MIKELANGELO stack on heterogeneous infrastructures, with high responsiveness, agility and better security. The targeted audience are primarily SMEs (e.g. simulation dependent SMEs). Finally, the use-cases have clear owners, thus directly contributing to the exploitation.


**Keywords:** hypervisor optimisation, I, O optimisation, guest operating system optimisation, application packaging, high performance cloud, high performance computing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Asymmetrical B cell division: origin and functional significance', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

B cell activation required for antibody production and the establishment of immunological memory is initiated by antigen recognition through the B cell receptor (BCR) and subsequent internalization of antigen for presentation to T cells. After activation, B cells proliferate and differentiate into plasma cells or memory B cells. The mechanism involved in this B cell fate decision has been recently explored and a new theory has been proposed based on the existence of an asymmetrical B cell division (1). This theory assumes the unequal inheritance of antigen between daughter cells due to antigen being rapidly polarized in a unique compartment that is maintained along B cell division. This polarity abolishes the uniform distribution of antigen vesicles between daughter cells, generating two functionally different B cells.This proposal is focused on understanding how this initial antigen polarity is established and maintained and what is its role in B cell activation. Furthermore, the functional significance of the asymmetrical B cell decision will be analyzed in vitro and in vivo. In addition, possible new parameters asymmetrically distributed that could also determine B cell fate decisions will be evaluated.During this project, a huge range of techniques including state-of-the-art microscopy (in vitro and in vivo methodologies), flow cytometry systems (multiparametric analysis and ImageStream) will be used and advance mathematical analysis approaches will be developed.Results from this proposal will contribute to the general knowledge of immunological responses, but more precisely will explain how different B cell populations are originated after B cell activation, a key step that is deregulated in some diseases such as cancer.1.O. Thaunat et al., Science 335, 475 (Feb 26
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Long-wave Ultrafast Multipurpose Intense Nonlinear-Optical Source' (LUMINOS).

assistant: **Concept**

Mid-infrared laser sources operating in the 3-10 µm wavelength range are of great interest and importance for a wide range of applications that span laser surgery with minimal peripheral damage; infrared sensing applications based on incredibly sensitive and species-selective vibrational finger-printing of molecules; countermeasures against intelligent homing munitions; etc. Recently, the high-field physics and attosecond science community became strongly interested in intense ultrafast sources operating in this notoriously difficult for lasers spectral range, signaling a big potential scientific market. Because of the absence of lasing materials, such sources are based on nonlinear-optical frequency conversion of near-IR pulsed lasers. To date, narrowband tunable high-energy low-intensity pulses from nanosecond Q-switched lasers and micro-Joule-level femtosecond pulses from cumbersome multistage down-conversion schemes driven by 800-nm Ti:sapphire amplifiers have been demonstrated. Project LUMINOS intends to jump-start the era of compact efficient sources operating in the 5-10 µm with at kHz repetition rates, several milli-Joule pulse energy and pulse duration nearing a single optical cycle. This breakthrough implies the development of an unprecedented femtosecond chirped-pulse laser amplifier at 2.1-µm to solve the problems in mid-IR parametric amplification linked to the pump wavelength, conversion efficiency, and amplified bandwidth. We propose to develop and offer for commercialization the first high-intensity and average power Ho-doped femtosecond solid-state amplifier and demonstrate it as a pump source for a mid-IR parametric amplifier. The technical idea and the feasibility proof behind this project arose during the implementation of the ERC project CyFi, in wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Impact of Environmental Agreements of the CAP'.

assistant: **Innovation**

The study has four primary objectives. 1. To make an assessment of the exact obligations falling on the Community with respect to agriculture in the fulfillment of commitments under the Kyoto Protocol and the CBD, clarifying how agriculture could contribute relative to other sectors of the economy and land users. 2. To undertake an analysis of the most appropriate adaptations and innovations in the agricultural sector required to meet the new objectives and obligations. This needs to be achieved within a consistent, methodical framework. It will focus on efficiency, particularly in economic terms, effectiveness, concerning different environmental outcomes and compatibility with other objectives and constraints, at the farm and wider national and EU levels. Interactions between CBD and Kyoto Protocol driven measures need to be exposed and analysed. Account will be taken of a wide range of conditions in Europe, both in existing and new Member States. Afforestation and forest management issues need to be considered alongside agricultural adaptations. 3. An assessment of how far these changes at farm level and upwards require alterations in policy, both at the national and EU levels. Policy change may be needed in the environmental, agricultural, forestry, research, regional support or other policy domains. The main focus will be on agricultural and rural development policies, especially those within the CAP. Specific measures of relevance to Candidate Countries need to be identified. 4. To complete and disseminate an integrated strategy for implementation of the two agreements in the EU agricultural sector, including concrete policy recommendations applicable at a European level such as good agricultural practice. Effectively this will combine the responses required for bo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Electronic transitions in the photosyntetic reaction center' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

This proposal is concerned with the characterization of electronic transitions in the Photosyntetic Reaction Center (RC). By means of combined Molecular Dynamics (MD) and spin-boson approach we plan to compute the band profile for the electron transfer relevant electronic transitions of the pigments in the RC. For a few eletronic states we shall use classical MD to compute the energy gap functions, using available semiempirical and/or ab initio model for the excited and ground states. In the framework of the simple spin-boson model, the MD computed energy gap function can be straightforwardly related to the electronic spectrum. Simulations will be carrid out using the untruncated Coulomb potential. A similar task can now be feasibly undertaken using the novel multiple time step algorithms. The use of the 'exact' Coulomb potential represents a major step forward in the simulation of biological systems. We will investigate the effect of the environment (protein units, solvents and neighboring chromophores) on the energy gap functions (and thus on the electronic band profile). In thiS fashion we hope to gain insights, at the atomistic level in the mechanism which drives electron transfer in the photosyntetic RC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'A differential geometric approach to nonlinear filtering - the projection filter'.

assistant: **Innovation**

In dealing with stochastic linear systems, predictions and estimates are computed via the Kalman filter. Generalization to non-linear systems is an important area of research. Unfortunately, the optimal filter for nonlinear systems is infinite-dimensional. Approximate filters for non-linear systems, as the extended Kalman filter, are of great practical value. A disadvantage of many filters is that they are based on heuristic considerations. A new class of filters, the projection filters, was developed by the applicant. These filters use an a priori given finite dimensional class of probability distributions and at each moment the change in distribution that is prescribed by the exact filter is projected on the linear space of changes corresponding to the chosen class of distributions. Computer simulations, existence of exponential families which simplify the filters, application to finance and theoretical analysis in case of small noise were developed by the applicant. Such results strongly motivate the prosecution of the project by mean of further simulations, further theoretical analysis and applications to financial and engineering problems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Characterization of the role of the FLOWERING LOCUS T mRNA transport in the regulation of flowering time'.

assistant: **Concept**

The regulation of plant flowering time is a highly adaptive trait. Plants must integrate a multitude of environmental and internal signals in order to flower at the right time of the year. One of the most important factors regulating flowering time is the length of the day, where some plants, like Arabidopsis, respond to a lengthening of the day in order to flower in the spring. Since the 1930s it has been clear that the day-length regulation of flowering time is controlled by a substance moving from the leaf to the shoot apex where the initiation of flower primordia takes place. This substance was called florigen. However, during the last couple of years several important breakthroughs have occurred for our understanding of the day-length regulation of flowering time which has now lead to the identification of a possible identity of florigen as the mRNA produced by the gene FLOWERING LOCUS T (FT). Using a system allowing heat-shock inducible expression of FT in a single Arabidopsis leaf, we could show that the FT mRNA moves from the leaf to the shoot apex where it induces downstream targets.We could also show that FT induces other targets in the leaf, including an autoregulation of its own transcription, and that ultimately the endogenous FT gene is also induced in the shoot apex. Together, these data showed that the FT mRNA fulfilled all the criteria associated with the classical florigen molecule, although, at the time we could not exclude that also the FT protein moves. This finding has lead to a completely new view of the mechanism regulating flowering time, and prompts a whole new set of experiments in order to further characterize the activity of FT and the possible regulation of the FT mRNA transport.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'POttery Use from the earliest Records of Patagonia through biomolecular analysis'.

assistant: **Objectives**

Since its birth in East Asia during the Late Pleistocene, ceramic technology has become almost universal, allowing the exploitation of new environments and fostering different kinds of cultural expressions. This worldwide relevance for human development has positioned the uses of early pottery as one of the most debated topics in archaeology. Traditional models that linked this technological breakthrough to the development of farming and sedentary lifestyles are currently being revisited, and new data from the Northern Hemisphere suggest that it would have been a hunter-gatherer innovation widespread by the processing of aquatic resources during sporadic episodes. However, some key regions of the Southern Hemisphere have remained unexplored. This is the case of the southernmost limit of pottery dispersal in America, the Patagonia region, where pottery was spread by foragers over a vast and marginal environment during 2000 years, but it remained as a scarce and low-scale technology. What was the initial motivation that drove Patagonian foragers to use and spread this technology in such an environment without engaging in intensive production? Could the stability of aquatic resources trigger this process and delineate a world-wide trend that transcends the ecological and cultural settings? By applying the latest biomolecular analysis and data interpretation methods, POUR seeks to answer this unsolved question implementing the first large-scale systematic research on the uses of early pottery in this part of the world.


**Keywords:** South American Archaeology,  Early Pottery,  Biomolecular Analysis,  Stable Isotopes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Thin Film Metallic Glasses for Tribological Applications' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The current proposal aims to demonstrate the potential of thin film metallic glasses as novel tribological coating materials, used to improve the performance of tools, dies, and moulds in many different applications. These coatings are characterized by a high hardness, as well as high wear- and oxidation resistance. Thin film metallic glasses are promising materials to fulfil these demands. Due to their amorphous structure they have excellent mechanical properties such as high specific strengths and large elastic limits above 2%. The absence of defects like grain boundaries also makes them resistant against corrosion and wear. In comparison to conventional protective coatings based on transition metal nitrides, thin film metallic glasses have the added benefit of a relatively low elastic modulus, making them tougher and able to accommodate a certain degree of substrate deformation without delaminating. In this study, amorphous WZrB coatings will be deposited by a combinatorial dc magnetron sputter process from three elemental targets onto commercially relevant substrate materials. The primary refractory element W provides the necessary temperature stability for tribological applications, while Zr and B have both been shown to enhance the glass forming ability in W-based alloys. Experimental activities will be supported by our company partner CERATIZIT Austria GmbH, a global leader in the hard metal tooling industry. The thin film metallic glass/substrate systems will be characterized with state-of-the-art methods in terms of their chemical, mechanical, thermal, and tribological properties. Results will be critically evaluated regarding the up-scaling potential of developed processes and materials systems from laboratory to industrial conditions.