RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Molecular and Structural Biology of Bacterial Transformation' to be submitted under Seventh Framework.

assistant: **Abstract**

A common form of gene transfer is the vertical gene transfer between one organism and its offspring during sexual reproduction. However, some organisms, such as bacteria, are able to acquire genetic material independently of sexual reproduction by horizontal gene transfer (HGT). Three mechanisms mediate HGT in bacteria: conjugation, transduction and natural transformation. HGT and the selective pressure exerted by the widespread use antibiotics (in medicine, veterinary medicine, agriculture, animal feeding, etc) are responsible for the rapid spread of antibiotic resistance genes among pathogenic bacteria.In this proposal, we focus on bacterial transformation systems, also named competence systems. Natural transformation is the acquisition of naked DNA from the extracellular milieu. It is the only programmed process for generalized genetic exchange found in bacteria. This highly efficient and regulated process promotes bacterial genome plasticity and adaptive response of bacteria to changes in their environment. It is essential for bacterial survival and/or virulence and greatly limits efficiency of treatments or vaccine against some pathogenic bacteria.The architecture and functioning of the membrane protein complexes mediating DNA transfer through the cell envelope during bacterial transformation remain elusive. We want to decipher the molecular mechanism of this transfer. To attain this goal, we will carry out structural biology studies (X-ray crystallography and high resolution electron microscopy) as well as functional and structure-function in vivo studies. We have the ambition to make major contributions to the understanding of bacterial transformation. Ultimately, we hope that our results will also help to find compounds that could block natural transformation in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Project SCALE: Tailored Digital Therapeutics for Neurological and Brain Disorders', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Beats Therapeutics specialises in digital therapeutics for neurological and brain disorders. There are over a billion people worldwide living with a neurological or brain disorder.  This has led to pressure on healthcare systems and payers to improve self-management and reduce long-term costs. The high risk and low approval rates of  neuro-pharmaceuticals has led to billions of dollars of annual losses for the pharma industry. Many of these failures have been attributed to an insufficient understanding of the brain. We deliver tailored assessments and therapy's for neurological conditions  with the aim to improve care and reduce costs while developing a greater understanding of neurological disease. Our core technology platform leverages data science and the advancements in hardware sensors to deliver cost effective daily assessments and individually tailored therapy to patients with neurological conditions. The innovation in this project is to scale up our current core technology platform in order to further deploy the technology in greater disease areas. Project Scale will allow us to enhance our core technology applicability to rapidly deploy disease specific technologies for pharmaceutical industry and payer industry while enhancing our global impact on patients’ lives.


**Keywords:** Digital therapeutics, machine learning, patient care, self-care
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'NUTRIGEN SERVICE: MANAGING HEALTH THROUGH DIETARY NEEDS, VIRTUAL CONSULTATIONS, AND GENETICS'.

assistant: **Objectives**

The WHO estimates that worldwide obesity has doubled since 1980. In 2014 more than 39% of adults were overweight. The EC estimated that healthcare costs related to obesity represent 7% of its total healthcare spending or €81B/yr. Obesity causes a range of very serious physical and mental health problems like diabetes, heart diseases, hypertension, etc. Obesity and its related illnesses are largely preventable through proper diet and exercise.We have created a disruptive new mHealth app, Nutrigen Service, to help users stay healthy by providing free diet/nutrition plans tailored to their lifestyle using our artificial intelligence algorithm. Our goal is to provide an effective/affordable mHealth tool capable of helping people mitigate, manage, reduce, and avoid health problems like obesity and related diseases. The first version of our app has more than 100.000 downloads giving us a TRL7. Currently we are able to provide diets for, Diabetes, Hypertension, High Cholesterol, Pregnancy, Lactation, Obesity, “Normal” diets for people without any of these problems, we will add diets for Gluten and Lactose intolerance. We also offer a DNA test to look for the presence of genes related to obesity as well as readings for Cardiovascular risk, Gluten, Lactose Intolerance, Telomere health.Our target market is the high volume mHealth market. In 2013 the global market revenue for mHealth was USD 2.4 billion, with a projected growth of USD 26 billion by the end of 2017. The size of the European market in 2014 was estimated at approx. €900M. Within the mHealth market we are focusing on the Nutrition, Wellness, Medical Condition Management, and Medical Reference sectors as they are 4 of the biggest sectors within the mHealth market. By targeting these 4 sectors we can access 46.10% of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Trends and Patterns of Interethnic Parnerships and Well-being of Mixed Ethnic Children in the EU' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

This projects aims to conduct a cross-national analysis of interethnic partnerships in the European Union. The study focuses on partnerships between natives and immigrants because interethnic union has long been regarded as an indicator of integration. Focusing on the 27 member states of the EU, this research will explore two main themes: 1) trends and patterns of interethnic partnerships; and 2) socioeconomic well-being of offspring of interethnic unions. The study will focus on explaining similarities and dissimilarities in interethnic partnership patterns of different immigrant groups across 27 member states based on an empirical analysis of the EU Labour Force Survey. Furthermore, arguing that interethnic partnerships can enhance bridging social capital and facilitate the integration of children growing up in an interethnic household, this research will investigate the well-being of offspring of interethnic unions measured by their development, educational achievement and health. The study will also attempt to explain the mechanisms through which a native parent promotes the children’s well-being through the lens of social capital. Focusing on children’s outcomes and using nationally-representative longitudinal surveys of selected five member states, this research is of methodological significance in tackling the endogeneity and sample selection problems which usually arise when studying offspring of interethnic unions. This project will add to the knowledge in integration and well-being of children from various immigrant groups in different societies in the EU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Noradrenergic Modulation of Hippocampal Post-Natal Development', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Many brain disorders with cognitive impairment originate during development, when synaptic and neuromodulatory circuits progressively emerge, mature and give rise to function. In the hippocampus, stereotyped sequences of brain activity patterns in early life are thought to set the stage for coherent cognitive and memory processes in adulthood, for which noradrenaline neuromodulation is also critical. However, surprisingly little is known about the developmental origins of hippocampal neuromodulation in general, and of noradrenaline transmission in particular, neither in health nor disease.In project HIPPNADEV, I will investigate the contribution of noradrenergic transmission to the post-natal development of the hippocampus: In other words, “if”, “when” and “how” noradrenergic signals acquire their cellular and circuit-level properties in the developing hippocampus. I will use a highly innovative, translationally relevant, multi-disciplinary and multi-scale approach, combining in mice anatomical and functional interrogation using cutting-edge technology including spatial transcriptomics and in vivo all-optical dual imaging of noradrenaline release and single-neuron calcium activity. Further, this project will compare the developmental trajectories and functional significance of hippocampal noradrenergic signals at baseline and in rodent models of schizophrenia.Altogether, it will significantly advance our understanding of hippocampal neurodevelopment on one hand – implicating neuromodulatory noradrenergic transmission therein – and vice versa elucidate still-unknown developmental aspects of noradrenaline transmission. Such breakthroughs will offer promising bases for future fundamental study of the neuromodulatory correlates of neurodevelopment, as well as a solid precli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'POLICY ANALYSIS OF TIMBER CERTIFICATION"AS A MARKET-BASED INSTRUMENT OF FOREST POLICY TO PROMOTE SUSTAINABLE MULTIFUNCTIONAL MANAGEMENT OF FORESTS"'.

assistant: **Innovation**

Background :Timber Certification" may help avoiding misguided consumers to turn away fromEuropean wood. It might also help to create added value and to promote sustainable forest management. It is important for the Community that Timber Certification is not implemented in a way that distorts the market by unjustified claims from different suppliers. The objective is : the evaluation of the demand for, the realism of and the potential impact of "Timber Certification".Short description of the project :The project will evaluate the demand for and the potential impact of "Timber Certification". The project will, inter alia, investigate consumer's willingness to pay and the forestry-wood chain attitudes to costs, criteria and organisational aspects. A close cooperation with DG VI F.II.2 is foreseen during the project."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Origins of the Roman Inquisition Reconsidered: the Diplomatic Career of Gian Pietro Carafa in England and Spain (1513-19)' in the context of a Seventh Framework call.

assistant: **Objectives**

The project aims to re-examine the formative years of Gian Pietro Carafa’s (the future pope Paul IV, 1555-59); specifically his diplomatic missions to England and Spain in the 1510s. Its objective is to reconstruct the relations Carafa enjoyed with the sovereigns Henry VIII and Charles V and their courts and determine the importance of these experiences for his later political and religious choices. In fact, in the 1530s the English king drew Carafa into the troubled affair of his divorce from Catherine of Aragon, while Carafa continued to show an unflinching hostility to Charles V and his son Phillip II which led to the unsuccessful war he unleashed against the Spanish King during his pontificate. In addition, it was in Spain that Carafa became familiar with the workings of the Spanish inquisitorial tribunal. My research intends to find out whether this institution later served as a model for the foundation of the tribunal of the Roman Inquisition which Carafa used to further his programme of intransigent and repressive reform. The project will also dwell on the reception Carafa was given by humanist milieus in northern Europe, particularly by Erasmus with whom Carafa had a controversial relationship that began with his initial acceptance of the former’s Christian humanism and philological projects for the Scriptures and ended with the Opera omnia Erasmi being included on the Index of Prohibited Books under Paul IV’s own pontificate. From this perspective the project also plans to study Carafa’s private correspondence to gain an insight into his personality, one that was apt to change according to demands of political expediency. The study of these aspects will culminate in a historiographical analysis of the conceptual categories of the Catholic Reformation and Counte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advances in Empirical Methods for Time Series and Forecasting in Unstable Environments' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The environment we live in is both complex and time varying. Examples of recent instabilities include the recent financial crises as well as the more recent COVID-19 pandemic and the war in Ukraine, which have substantially altered our world. Currently, however, the way researchers implement forecasts as well as the way they estimate the effects of economic policies is based on methods that either impose restrictive assumptions on the nature of instabilities or quickly become computationally demanding in the presence of instabilities.This project proposes to develop a local projection-based estimator for time-varying parameter models and their impulse response functions in unstable environments, which we refer to as the “time-varying parameter local projection” estimator (or “TVP-LP” in short). The proposed estimator is expected to provide a feasible approach to conveniently and flexibly estimate economic models in unstable environments as well as, more broadly, forecasting and assessing the effects of economic policies. The proposed estimator can be generalized to include instrumental variables as well as be applied in vector autoregressive models with external instruments while being robust to the presence of instabilities.  The proposed methodology is expected to have widespread applicability given the increasing interest in using convenient local projection estimators and the substantial evidence of instabilities in macroeconomic models.In contrast to conventional time-varying parameter VAR models, the proposed time-varying parameter local projection estimator is robust to the presence of non-invertibility due to omitted variables and misspecification and its estimation is less computationally challenging.The advantages of the methodology will be illustrated in term
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Visible Light-Mediated Copper Photoredox-Catalyzed Ring-Opening Transformations of Activated Small Ring Aza-Heterocycles and Carbacycles' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

PhotoCuRiOT is envisaged and designed to develop novel synthetic tactics to biologically significant cyclic and acyclic nitrogenous organic compounds via visible light-mediated Cu(I)-based photoredox catalyst-assisted ring-opening transformation of small ring aza-heterocycles and aminocarbacycles. Considering the earth abundance and low cost, Cu(I)-based complexes, especially copper(I) phenanthroline derivatives, are recently being used as efficient photocatalysts and as low-cost alternative to the Ru or Ir-based complexes. A range of Cu(I)-complexes will be screened for optimizing the efficiency of the aforementioned ring-opening transformation processes. The most effective catalyst will oxidatively activate the substrates and the reactions will proceed through the generation of photoinduced reactive species (primarily amino radical cations) that can be productively harnessed for the synthesis of a range of high-value functional motifs after successive ring opening and annulation with suitably functionalized nucleophiles. PhotoCuRiOT will address the long-standing problem of finding an appropriate classical activation mode for different varieties of small ring aza-heterocycles (non-activated and activated) by offering a unique generic activation mode through the formation of amino radical cationic intermediates. PhotoCuRiOT also aims to bridge the gap between the fields of medicine and energy by enabling facile and highly selective synthesis of a wide array of high value heterocyclic moieties by utilizing copper complexes as environmentally benign photoredox catalysts and visible light as a sustainable source of energy. The successful photoactivation and subsequent ring-opening/expansion transformations of azacyclopropanes and azacyclobutanes would also allow late stag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'NANOPARTICLES FOR THERAPY AND DIAGNOSIS OF ALZHEIMER DISEASE' in the context of a Seventh Framework call.

assistant: **Objectives**

The search for effective therapies and early detection strategies for Alzheimer’s Disease (AD), the major cause of dementia in Europe, is imperative. It is known that β-amyloid (Aβ) peptide plays a central role in neurodegeneration. In AD brain, Aβ is released in a soluble form that progressively becomes insoluble forming aggregates; extracellular plaques mainly composed of Aβ are a hallmark of post-mortem brains. These premises strongly suggest brain Aβ as a possible target for therapy and diagnosis of AD. In addition, it is known that brain and blood Aβ pools are in equilibrium via the blood-brain-barrier (BBB). Accordingly, it has been reported that removal of blood Aβ may withdraw the excess of brain Aβ by a “sink” effect. Thus, blood Aβ is another potential target. The aim of this project is to utilize nanoparticles (NPs) specifically engineered for targeting brain Aβ, for the combined diagnosis and therapy (theranostics) of AD. NPs (liposomes, solid lipid NPs, polymeric-NPs) will be multiple-functionalized with: i) a large arsenal of molecules (specific lipids, antiamyloidogenic drugs, polyphenols, heteroaromatic compounds, unnatural peptides and peptidomimetics, antibodies) interacting with Aβ in all aggregation forms, ii) PET or MRI contrast agents detecting such interaction, iii) molecules stimulating BBB crossing via the transcytotic route. Several artificial and cellular models will be used to fine-tune such features and to improve NPs biocompatibility, non-immunogenicity, non-toxicity and physical stability. Eventually, absorption, distribution, metabolism and excretion will be studied using animal models of AD. Different routes (i.v., oral, nasal) and protocols (two-step, NPs cocktails, aerosols) of administration will be utilized to boost NPs brain deliver
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '5G DRIVEn Resource Efficient Mobile Aggregation Networks' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The fifth generation (5G) cellular networks set ambitious goals that require technological advances in both wireless and transport network infrastructures, especially regarding cost and carbon footprint. In this context, a promising architecture for 5G aggregation networks is the recently proposed Claud-Radio Access Network (C-RAN). However, it will face the serious challenges related to (1) efficient use of network resources, (2) low-latency requirements, and (3) scalability. Seems that optical aggregation networks based on wavelength division multiplexing are the outstanding candidates to meet high-capacity and low-latency requirements. However, to reduce cost and power consumption, there has been a recent push towards the consolidation of the network by merging the access and metro transport where flexible-grid transmission is also considered. This becomes questionable in the context of the traditional C-RAN. Therefore, alternatives are being analysed including different function splits between cell-site and baseband equipment, and millimetre-wave carriers instead of optical carriers for interconnecting cell-site equipment and access central office. Hence, 5G-DRIVE project aims to explore the impact of transport cost and wireless channel (de-) aggregation technique on resource efficiency (cost, spectrum, power consumption) and service availability in aggregation network that uses optical or millimetre-wave carriers for interconnecting cell-site and baseband equipment.


**Keywords:** 5G cellular networks, fibre-optic transmission, x-haul, resource efficiency, optimization