RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The PomXYZ cluster in the bacterium Myxococcus xanthus: Self-assembly, translocation, and fission of an active protein complex that guides cell division' (PomXYZ).

assistant: **Concept**

In my research project I will theoretically model a fundamental process in the cell division of the model bacterium Myxococcus xanthus, namely the process for guiding the machinery for cell division to midcell. In M. xanthus, a cluster comprised of the proteins PomX, PomY, PomZ self-assembles on the nucleoid surface and in an ATP-consuming reaction cycle translocates to midcell, to guide the cell division machinery there. During cell division the Pom cluster undergoes fission, and the resulting two Pom clusters on the daughter cells again translocate to the respective midcell to induce further cell divisions. I will consider a mesoscopic model which combines spatial dynamics with locally stimulated reactions, to study the formation, translocation, and fission of the Pom cluster. My model is informed, and will be further refined, using experimental results of the group of Lotte Sgaard-Andersen at the MPI for Terrestrial Microbiology, an established collaborator of my supervisor Erwin Frey. I will quantify the constraints imposed on the protein-protein and protein-nucleoid interactions by the tasks the Pom cluster needs to fulfill (self-assembly, translocation, fission), and relate my mesoscopic model both to previously proposed heuristic models on Pom cluster translocation and to (stochastic) reaction-diffusion models.  My project will lead to a deeper understanding of how biological systems actively create and maintain order. My mesoscopic model combines spatial dynamics with locally stimulated reactions, which are the two conceptual building blocks needed for spatial organization driven by energy consumption. My model will therefore be applicable also in other instances of biological self-organization, as well as in self-assembly of artificial nanostructures, both of w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Fluorescent caged phosphopeptides as probes to investigate glutamate receptors trafficking at the synapse level by time and site specific modifications of PICK-AMPAR interactions', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The aim of this project is to devise new chemical probes to investigate specific protein-protein interactions in neurons. The probes include caged phosphopeptides, which are fluorescently labelled to enable, for the first time, site and time specific perturbation of receptor trafficking and stabilisation at the level of individual synapses.This project represents a unique combination of advanced chemistry with high-resolution imaging. We will concentrate on processes involved in the regulation of synaptic transmission at excitatory glutamatergic synapses. Namely, the main focus will be on interfering with the interaction between AMPA type glutamate receptors and the associated scaffold proteins PICK and GRIP. Phosphorylation dependent regulation of this interaction is indeed emerging as a key player in the processes of synaptic plasticity thought to underlie learning and memory.The first goal of the work in the Imperiali laboratory will involve synthesis of a family of fluorescently labelled caged phosphopep tides. The tools developed in the Imperiali group will then be used in the Choquet laboratory to investigate the rules underlying receptor trafficking in multiphoton and single molecule imaging experiments combined with electrophysiological recordings of synaptic transmission.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a novel class of therapeutics for PTSD treatment and other neurodegenerative disorders' (FENM4PTSD), addressing dissemination and exploitation.

assistant: **Impact**

ReST Therapeutics is a French biotech company founded late 2020 that develops breakthrough therapies to treat complex central nervous system disorders, in particular, Post-Traumatic Stress Disorder (PTSD) under its various forms followed by Alzheimer Disease (AD).Our lead candidate - FENM is a novel and proprietary chemical entity (NCE) targeting specifically a subtype of NMDA receptor (involved in synaptic plasticity) in order to facilitate stress release and neuroprotection without triggering adverse side effects of current NMDA targeting drugs. FENM will enter First-in-Human in June 2023 to initiate the clinical demonstration on PTSD. ReST is also advancing new compounds to generate a robust library of candidates and generalize its NMDAr subtype modulation platform with the potential to treat other neurologic disorders. With the EIC support, ReST will bring FENM to clinical PoC (PhIIb) by 2027, secure a partnership with a pharma company and develop new small molecules to expand its pipeline.


**Keywords:** Post-traumatic stress disorder, Neurological disorders,  Synaptic plasticity, NMDAr antagonist, Neurodegenerative diseases, learning and memory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Force Servo', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Servo drives are small devices that have an output shaft, which can be positioned to specific angular positions by sending the servo a coded signal. Development of autonomous vehicles, drones, advanced robotic manipulators, camera stabilizers and other innovations require servo drives that are able to react and imitate the force of a living being. Absence of such solution creates a market gap in these industries and stagnate revolution of autonomous devices.Currently, there are no commercially available servo drives on the market that can fulfil the performance requirements needed for development of new generation autonomous devices.Force Servo (TRL 7), developed and patented by My Research is a new type of servo drive with controllable action force. The value of force is proportionate to the control signal and does not depend on the position of the arm, while the force is controlled with a force sensor. Force Servo improves technical characteristics of many autonomous devices, by providing simplicity, accuracy, lightness, energy efficiency, and replicating the force of a living being.To demonstrate advantages of Force Servo, the company will first commercialize a video camera stabilizer integrated with Force Servo drives. Such stabilizer is smaller, lighter and better performing than any alternative on the market. In the future, My Research will standardize and commercialize Force Servo drives in all relevant market segments – video stabilization, robotics, bionics, remote controlled vehicles, interactive interface, etc.To ensure successful commercialization, in Phase 1 of SME Instrument, Nord Robos Holding intends to develop an elaborate feasibility study for My Research Force Servo drive commercialization that would include: identification and contacting target users
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Improved Patient Safety through Intensive Biosignal Monitoring' (IPSIBiM) targeting Horizon 2020.

assistant: **Abstract**

Hospitals can experience difficulty in detecting and responding to early signs of patient deterioration, leading to late intensive care referrals, excess mortality and morbidity, and increased costs. Joint replacement is a very common orthopaedic operation that raises additional clinical and safety questions. Caring for the orthopaedic patient requires a multidisciplinary team and treatment that includes: acute pain control, monitoring for post-operative complications venous thromboembolic prophylaxis, early ambulation, and rehabilitation. The major limitation of early warning systems is that they are based on manual checks performed by nursing staff, and that the observations, and therefore detection, only occur intermittently. Additionally, the false-alarm rate of such monitors is generally so high that the alarms are usually ignored. Despite recent developments in automated wireless systems that continuously record vital signals, a method for detecting patterns of deterioration that are specific to unique patient populations has not yet been studied. IPSIBiM targets the development of a system dedicated to post-operative orthopaedic patients monitoring based on wireless recording of real-time vital signs and analytical algorithms capable of providing guidance to clinicians of early signs of deterioration. The innovation in the project consists of four main elements: measurement of new vital signs in a wireless system; novel methods for deriving features and building models to measure recovery; automated pain measurement in post-operative patients; principled methods for novelty detection. The proposed concept will be implemented in a clinical feasibility study, where technical aims related to setting up the system, reliability and failures will be studied along with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sustainability And Procurement in International, European, and National Systems' to be submitted under Horizon 2020.

assistant: **Abstract**

Objectives: Sustainable public procurement – SPP is about incorporating considerations pertaining to the environment or to social aspects in purchasing decisions. SPP can considerably contribute to the achievement of the UN Sustainable Development Goals. SAPIENS will develop the scientific analyses needed for enhancing SPP and provide buyers in the public sector with tools to procure sustainably, in compliance with the applicable international and EU rules. Strategy: Unleashing the potential of SPP requires a new generation of experts capable of working across disciplines (law, economics, business sciences) and knowledgeable of the different relevant methodologies. SAPIENS will train the first generation of SPP experts sharing a common understanding of the challenges faced in achieving the SDGs. The PhD interdisciplinary research will focus on 15 innovative SPP topics articulated along three axes: (a) SPP from the international agenda to actual buying practices (actors, sustainable economics, new approaches to public buying), (b) procurement to achieve the SDGs (incl. human, workers, women rights, different environmental concerns, SMEs), and (c) sector-specific applied SPP (construction, textiles and catering). Relevance: Target 12.7 of the SDGs specifically focuses on promoting “public procurement practices that are sustainable, in accordance with national policies and priorities” but SPP is relevant for and may contribute to the achievement of most SDGs. Public procurement – PP also plays “a key role in the Europe 2020 strategy […] as one of the market-based instruments to be used to achieve smart, sustainable and inclusive growth”. Enabling and enhancing SPP on the lines of the SAPIENS fully answer a relevant societal need, as proposed by the H2020 program.


**Keywo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Single cell module integrated converter system'.

assistant: **Objectives**

Objectives Grid connected Photovoltaic (PV) Systems offer a very promising technology for an environmentally acceptable way of electricity generation. Today, the most serious drawback is the high energy cost compared to conventional energy sources. Therefore, the overall objective of this project is a substantial decrease in manufacturing cost of grid connected PV-Systems. Technical Approach The approach is threefold: - the manufacturing process of PV-modules can be simplified and therefore become less expensive if the series connection of cells can be avoided; - the overall performance of a grid connected PV-system may be improved by introducing the concept of Module Integrated Inverters (AC-modules); - the cost can drastically be reduced if the substrate" for the cell is a conventional and already mass produced building element. The series connection of cells will be avoided by using thin film technologies, e. g. double or triple junction amorphous silicon, which allows deposition on large areas in a continuous process. Suitable technologies will be developed by NAPS France. These types of cells will produce very high currents (100 A) at very low voltages (1 V). Common inverter topologies are not suitable for these operation conditions. New concepts will be developed by ETH Zürich (CH) and Fraunhofer Institute for Solar Energy Systems, Freiburg (D). Finally, the new approach has to be converted into a product which can be used for building integration, e. g. as cladding elements. This task will be tackled by Alusuisse and Enecolo (CH). Expected Achievements and Exploitation The goal is to reach a preliminary product, which can be brought to the production level within a short time period. Three companies are involved in the project, which will guarantee an industrial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Levitation with localised tactile and audio feedback for mid-air interactions' (Levitate) under Horizon 2020.

assistant: **Objectives**

This project will be the first to create, prototype and evaluate a radically new human-computer interaction paradigm thatempowers the unadorned user to reach into levitating matter, see it, feel it, manipulate it and hear it. Our users can interactwith the system in a walk-up-and-use manner without any user instrumentation.As we are moving away from keyboards and mice to touch and touchless interactions, ironically, the main limit is the lack ofany physicality and co-located feedback. In this project, we propose a highly novel vision of bringing the physical interface tothe user in mid-air. In our vision, the computer can control the existence, form, and appearance of complex levitating objectscomposed of ""levitating atoms"". Users can reach into the levitating matter, feel it, manipulate it, and hear how they deform itwith all feedback originating from the levitating object's position in mid-air, as it would with objects in real life. This willcompletely change how people use technology as it will be the first time that they can interact with technology in the sameway they would with real objects in their natural environment.We will draw on our understanding of acoustics to implement all of the components in a radically new approach. In particular,we will draw on ultrasound beam-forming and manipulation techniques to create acoustic forces that can levitate particlesand to provide directional audio cues. By using a phased array of ultrasound transducers, the team will create levitatingobjects that can be individually controlled and at the same time create tactile feedback when the user manipulates theselevitating objects. We will then demonstrate that the levitating atoms can each become sound sources through the use ofparametric audio with our ultrasound array servin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Acelluvax - social acceptance and economic impact of a recombinant vaccine'.

assistant: **Objectives**

The exciting promises associated to biotechnology in the 80's have generally been deceived. There are several reasons behind such phenomenon: i.e. difficulties in the transfer of new knowledge from the labs to the market, but also problems of social acceptance of biotechnology processes and products. Indeed, in several European countries and in the US biotechnology often raised controversies and conflicts due mainly to ethical and safety reasons. Such controversies seem to be stronger when the environment and human health are involved (see Eurobarometer 35.1 and 39.1 on Biotechnology). The cultural and social factors able to influence the public perception of biotech may indeed play a stronger role when the concepts of nature and human life are directly called. Instead when therapeutic applications are examined. the social acceptance seems to be wider (see again Eurobarometer). Even in the case of vaccines. the development of recombinant products does not seem to raise particular controversies. Considering that: the use of traditional vaccines meets some social resistance due to ethical and safety reasons; and that the vaccine sector can be viewed as a strategic area for the drug industry (as recently confirmed by the European Commission with the establishment of a special task-force); the apparent paradox of a smooth marketing and a good social acceptance of a recombinant vaccine can be considered as a very interesting case to be studied. We here propose to analyse in detail the case- history of ACELLUVAX, a recombinant vaccine against whooping cough. that has been produced and extensively used in Italy without meeting any problem of acceptance. Whooping cough is a disease caused by Bordetella pertussis, a bacterium which colonises the upper respiratory trait of humans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'JIHAD OR RE-INTEGRATION: PATHWAYS OF FOREIGN FIGHTERS AFTER WAR' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Foreign fighters pose a serious threat to Europe. Western intelligence agencies believe that approximately 400 foreign fighters have returned to the EU from Syria and Iraq,  and that at least 250 radicalized individuals have been smuggled to Europe from 2014 until 2016.  The major hotbeds of foreign fighters smuggling and recruitment are located in Europe itself, in Bosnia and Kosovo, both of which underwent civil wars that featured foreign fighters. We know little about how foreign fighters behave in the aftermath of such civil wars: why some continue fighting in other wars while others go back to civilian life. This is an unfortunate shortcoming because numerous studies have shown that some foreign fighters have demobilized in the aftermath of wars in Afghanistan and Bosnia, while others left for Chechnya, Iraq and Syria to continue jihad. Those who continued fighting built networks with terrorists who are responsible for recent attacks in Europe. It is, therefore, imperative to understand these dynamics in order to make sound decisions that can prevent terrorism in Europe. This project will remedy this shortcoming by pursuing three goals. First, the project will adopt a fresh theoretical framework for the study of foreign fighters. Drawing on organizational theory, career transition and political violence literature, the project aims to explain post-war pathways of foreign fighters as a function of their role in previous war(s). Such an approach goes beyond standard focus on motivations and will help elicit why foreign fighters demobilize or turn violent in a long-term perspective. Second, the project will obtain new empirical insights into how foreign fighters pursued different paths in two similar, post-conflict contexts (Bosnia-Herzegovina and Kosovo). The third o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Optimal design and implementation of azimything pods for a safe and efficient propulsion ships (OPTIPOD)' (OPTIPOD) under Fifth Framework.

assistant: **Objectives**

Azimuthing pods are now used for the propulsion of large passenger vessels, for many reasons:- global efficiency, - manoeuvring performances, - improvements in design and building of the vessel,- industrial competitivity, etc.Up to now it is mainly a European business, giving some technical and economic lead to companies involved in this market. The extension of such pods to many other types of ships will be effective within few years. It is then time to study all the consequences of the selection of azimuthing pods on design and operation of the ships, and also on safety and environment.The OPTIPOD consortium includes partners of all types connected with design, building and operation of azimuthing pods and podded-drive ships. The objective is to produce design and operation guidelines, and to support the development of pods with a full control of all consequences. The study is divided into Work Packages covering the complementary aspects, and the work is shared between partners in line with their facilities and know-how. The industrial aspects and the exploitation perspectives are the main priorities.