RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of a fully automated, integrated solution that can support a wide range of complex sample preparation protocols' (SPCard) under Seventh Framework.

assistant: **Objectives**

A growing number of molecular diagnostics (MDx) tests help identify risk factors for disease, characterise disease status and subtype, and determine when and which therapeutic intervention is needed. However, MDx tests are labour intensive, require specialised infrastructure and require highly trained personnel. Only a limited number of MDx systems offer sample preparation but often require manual intervention or are targeted at high-throughput analysis. Integrated cartridges for point-of-care solutions today cannot support a wide range of complex sample preparation protocols. The aim of this project is to develop for the first time a fully automated, integrated solution that can support a wide range of complex sample preparation protocols. The integrated cartridge will be developed so that it incorporates all necessary functionalities for the typical biochemical steps of such sample preparation protocols. Biocartis, a biotech company, is engaged in the development of novel diagnostic technology platforms for low to highly multiplexed detection of molecular-based biomarkers. This fellowship will provide Dr Penterman with the opportunity to experience and learn more about the development phases i.e. implementing a rapid prototyping protocol for the introduction of different functionalities to support different biochemical steps, prototype design, production and assembly. An understanding of the functional testing that will be required to validate the prototype for a first application (Pathogen DNA enrichment) will be necessary to develop the cartridge to meet the needs of the complex protocol. His geographic transfer from The Netherlands to Belgium and from a large multinational company to a start-up SME reflects genuine mobility. The training offered will allow Dr Pente
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Mind the Gap: Mechanism and Impact of Ceramide Trafficking at the ER-Mitochondrial Interface'.

assistant: **Innovation**

A principal cause of failure in the treatment of cancer is that cancer cells develop resistance to chemo- and radiotherapy, leading to recurrence of the disease or even death. Sphingolipid molecules can modulate the ability of malignant cells to grow and resist anticancer regimens, with some molecules promoting tumorigenesis and others acting as tumor-suppressors. The tumor-suppressor activity of ceramides has prompted development of different formulations of synthetic ceramides in anticancer therapies, but the poor solubility of these compounds restricts their biocompatibility. Therefore, attention is increasingly focused on possibilities to manipulate cellular sphingolipid balances from within.The recent discovery of a ceramide sensor that protects cells against ceramide-induced cell death marks an important breakthrough. Disrupting sensor function causes accumulation of ceramides in the endoplasmic reticulum (ER) and their flow into mitochondria, triggering a mitochondrial pathway of apoptosis. While these results define the transfer of ER ceramides to mitochondria as a key determinant of cell fate, the molecular principles that govern ceramide trafficking at the ER-mitochondrial interface remain to be established.In this project, I aim to unravel the transport mechanism by which ER ceramides can reach mitochondria to initiate apoptosis. I will conduct a chemical screen employing photoactivatable and clickable ceramide analogues to identify ceramide-binding proteins operating at the ER-mitochondrial interface. As complementary approach, I will conduct a functional screen to search for proteins required for delivering ER ceramides to mitochondria. This screen is based on the principal that blocking expression of such proteins would prevent cells with a disrupted ceram
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Demonstration of a novel and scalable, compact air purification module for HVAC systems and ducts – the Nano Purifying System'.

assistant: **Objectives**

VLopes is an SME accounting for 20 years of experience in designing, developing and delivering air conditioning, ventilation and environmental control solutions such as air handling units (AHU) for leading players across industry sectors (incl. Airbus, Bosch, Danone, Continental Mabor and IKEA). Based on this experience, we have developed an all-in-one and one passage purification module – the Nano Purifying System® (NPS®), to meet the recurrent market needs for a solution that is, at the same time, compact, capable of high throughput and efficiency, fulfilling the strict requirements of sensible environments.The innovation of NPS stands on the combination of three air treatment technologies in one single and compact module – enabled by a patented layout/geometry, which maximises treatment. The NPS® is flexible and suitable for new and retrofit applications – it can be attached to HVAC systems as an independent and complementary module or installed directly in duct. Comparing to a setup with the same purification efficiency, NPS presents a much more compact format with lower pressure drop, with potential to save operational costs in the order of 42% in energy consumption. NPS® will be a game changing for VLopes, enabling the company to scale the business by supplying the high-end market with this compact and universal pre-verified system. The HVAC market is a multibillion euro market, and VLopes sees this innovation project as a great opportunity to leverage their business, while solving key challenges within this sector. VLopes expects to achieve an accumulated turnover of €12.1 million and +120 employees by 2024, through direct sales. Thereafter, we may pursue contract manufacturing and/or licensing opportunities. The SME Instrument project will be an important vehicl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European organizers of external quality assessment / proficiency testing schemes related to occupational and environmental medicine' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The Network Participants have:- Proposed quality specifications for measurement of lead in blood and aluminium in serum and will be applying these to a comparison of analytical performance by laboratories throughout the EU;-Identified variations in the implementation of EU legislation and considered the implications of these on analytical quality specifications and the organisation of EQA schemes;-Documented the repertoires and other management information of laboratories participating in the EQA schemes;-Prepared an audit of the organisational and managerial practices within the EQA schemes to identify those areas of common practice and those where mutual recognition would be possible;-Proposed a mechanism to facilitate harmonisation among schemes and to enable the establishment of new cross-national EQA activities; -Developed a culture that is now able to embrace metrological concepts and is seeking to (i) similarly educate scheme participants (ii) apply these to the organisation of EQA schemes;-Submitted one paper for publication, prepared two others that are almost ready for submission and presented one paper at a scientific conference.Undue exposure to harmful agents may occur at work or from environmental sources. Measurements of exposure are achieved by determination of the agent involved (or of a metabolite) in an appropriate specimen (urine, blood). Such measurements are also necessary to the follow-up of incidents of overt toxicity. Biological monitoring is an essential activity and is undertaken in many laboratories throughout the EU. As the determination of accurate results is crucial it is important that properly validated methods are used and that independent assessments of performance (external quality assessment, EQA) are undertaken. However, it has been
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Exhaust Particle Number and Mass Measurement and Sampling System'.

assistant: **Concept**

This proposal aims at the design and manufacturing of an instrument and a sampling system for the measurement of aerosol particles in the exhaust of vehicles and engines. Compared to commercial systems, the innovative elements of the current proposal are (1) the ability to measure both the mass and the number of particles in real time, (2) the possibility to measure both upstream and downstream of exhaust aftertreatment systems with constant dilution ratio, not affected by the aftertreatment backpressure, and (3) the compliance with the PMP requirements with respect to the treatment of the sample (heating, penetration, dilution ratio adjustment). The instrument and sampling system will be fully integrated and will be controlled by the same graphical user interface platform. The system will be able to perform measurements both in an engine test cell but also on-board a vehicle, so could be also considered a portable emission measurement system (PEMS). Such an instrument is expected to be a global performer in exhaust particle measurements. The success of the project is based on the strong partnership of an aerosol measurement instrument manufacturer (Dekati, Ltd – Finland), a mechanical engineering university lab with long experience in automotive exhaust measurements (LAT/AUTh - Greece) and a vehicle manufacturer which can provide the experience for the final validation of the instrument. The proposal requires a strong collaboration between mechanical engineers and aerosol experts from the very first stages of instrument development to make sure that the principles and the implementation of the instrument will be fully compatible with the engineering requirements set by the regulations and the practical limitations of the instrument use in an engine measurement facility
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advanced interfaced microsystems Research for analysis of Real-wOrld clinical, food, environmental and Waste Samples' to be submitted under Seventh Framework.

assistant: **Abstract**

The goal of ARROWS is to develop a microengineered platform for the analysis of 'real-world' samples from the food, drink and healthcare industries.  The principle deliverable will be a chip-scale capillary electrophoresis/liquid chromatography mass spectrometer (CE/LC-MS) that matches the performance of today's mainframe systems.<br/>The ARROWS innovation is to integrate and interface multiple chip technologies into a platform capable of analysing messy, sticky biological matrices like tissue, food, blood and urine.  Our vision is to offer users from the food, environmental and clinical sectors 'more for less' by delivering the functionality of a laboratory-scale, high-end CE/LC-MS system, which today is the size of a filing cabinet, in a mass-deployable tool the size of a desktop PC.<br/>Next-generation micro-analytical devices from Tyndall, Microsaic, VTT and CSEM will be combined into powerful, multi-sensing tools capable of identifying trace quantities of the chemical species of interest (e.g. pesticides, disease biomarkers) in complex biological matrices such as tissue, food and drinking water.  Microsaic Systems will develop a  MS based on patented ionchip technology.<br/>CE/LC/MS is a universal technique and analytical applications are unlimited.  Initially, ARROWS will focus on two applications: (a) detection of cancer biomarkers in fractional spots found on tissue, and (b) screening of imported food for contamination.  End-users Charité Universitätsmedizin Berlin and DEFRA will evaluate the platform.<br/>ARROWS utilizes the consortium's 'best-in-class' capabilities to exploit the scaling laws associated with microfluidics, chip-based chromatography and electrophoresis and microengineered advanced mass spectrometry to minimise analysis time, sample volume and r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Making the European Fisheries Ecosystem Operational' (MEFEPO) targeting Seventh Framework.

assistant: **Abstract**

Since the reform of the EU Common Fisheries Policy in 2002, effort has been devoted to addressing the governance, scientific, social and economic issues required to introduce an ecosystem approach to European marine fisheries.  Fisheries management needs to support the ‘three pillars of sustainability’ (ecological, social and economic. Fisheries Ecosystem Plans (FEPs) were developed to further the ecosystem approach in fisheries management and as a tool to assist managers consider the ecological, social and economic implications of their decisions. The FP5-funded European Fisheries Ecosystem Plan (EFEP) project developed a FEP for European waters, using the North Sea as a case study.  The core concept of the Making the European Fisheries Ecosystem Plan Operational (MEFEPO) project is the delivery of an operational framework for three regional seas. This is the necessary next step in the process. Furthermore, MEFEPO will, based on the lessons learned consider how FEPs can be made operational and developed for other regional areas. MEFEPO will focus on how best to make current institutional frameworks responsive to an ecosystem approach to fisheries management at regional and pan-European levels in accordance with the principles of good governance. This will involve developing new linkages and means of allowing dialogue between the disparate groups of stakeholders, the integration of the considerable body of ecological, fisheries, social and economic research which has been developed in recent years and investigate how existing institutional frameworks need to evolve to incorporate this information and develop both dialogue between the disparate groups of marine stakeholders and develop a decision-making process which integrates a wide breadth of interests. The three area
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'High precision reactor neutrino programm at APC', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This proposal has been designed for Dr Novella to become involved in fundamental neutrino oscillation research with the Double Chooz (DC) experiment, led by Dr de Kerret and Dr Cabrera (at the AstroParticule et Cosmologie laboratory). DC is the most competitive EU-based neutrino oscillations experiment, which leads the world on the measurement of the PMNS mixing matrix parameter theta13. DC should improve the current limit by x7 from the best limit to date set by the CHOOZ experiment. The main challenge for DC is to reduce significantly the systematic errors arising from the flux uncertainties. Thus, two identical detectors are used such that the neutrino oscillation signal extraction is independent from the flux normalisation. DC, in addition, is expected to have a critical impact to pave the technological ground necessary for both the improvement of future reactor experiments and the use of neutrino detector to monitor the evolution of fuels in nuclear reactors. The International Atomic Energy Agency is particularly interested in the latter results as they could help to solve difficult socio-political problems arising when nuclear reactors are used to generate non-authorised substances aiming military ends.This proposal relies on two remarkable matches: i) that between the fellow profile and the training offered by the host through activities in DC and ii) that between the time-scale of the proposed project and the experiment schedule. This proposal embodies an excellent opportunity for the fellow to diversify his research career in the leading research of his interest while reinforcing his professional maturity by granting him with responsibilities in core systems of the experiment. The project will be wrapped up with the neutrino oscillation data analysis leading to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Conformal growth of high-quality lateral III-V LEDS on silicon by hydride and metalorganic vapor phase epitaxy' (CONFORM) targeting Fourth Framework.

assistant: **Abstract**

The overall objective of the CONFORM project was to determine precisely the potentialities and to develop, in parallel by MOVPE and HVPE, the conformal growth technique, known to produce high quality GaAs layers on Si. The final expected demonstrators were lateral LEDs with various structures, as advanced as possible (double heterostructure with vertical quantum wells ideally).Intermediate objectives were1) the demonstration of conformal growth by MOVPE what required the development and selection of suitable precursors and the optimisation of the growth conditions,2) the mastering of the selective and conformal growth processes by HVPE and3) the successful modulation of both doping (n- and p-type) and composition during conformal growth by both techniques.Precursors for selective and conformal growthsThe development of the optimum precursor systems for the selective and conformal growths of In, Ga and Al alloys by MOVPE was first carried out. Chemical compatibility and source purity were key topics to establish selective deposition capabilities and to enable device quality structures to be fabricated. Epichem were expected to deliver novel precursors of the highest possible purity to the growth team and establish the best combinations. Also strategies were to be prepared to enable the introduction of the optimum precursor combinations to a commercial production environment.Epichem have been successful in identifying the optimum precursors for conformal MOVPE of In, Ga and Al alloys and establish production methods capable of yielding ultra high purity batches of these materials. Supply of source material to the growth team has been maintained throughout the project.The precursor development performed by Epichem was intended to result in a novel range of precursors suita
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Flow visualization inspired aero-acoustics with time-resolved Tomographic Particle Image Velocimetry', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The recent developments of the Tomographic Particle Image Velocimetry technique and of the non-intrusive pressure field characterization method, by the applicant at TU Delft Aerospace Engineering, now opens unforeseen perspectives in the area of unsteady flow diagnostics and experimental aero-acoustics. As a result of this work it is now possible not only to quantify complex flows in their three-dimensional structure, but also to extract quantities such as pressure. The current research proposal aims at the development of an innovative approach to experimental aero-acoustics and flow control making use of the recently developed Tomographic-PIV technique. The objective is to fully describe and quantify the flow pattern and the related acoustic source term at its origin, which is of paramount importance to understand and control the processes like acoustic noise production and flow separation dominating aerodynamic drag. This is relevant for the improvement of aircrafts design as far as drag reduction and noise emission is related and should enable the development of ""greener"" aircrafts for a sustainable growth of aviation in populated areas, in harmony with the technology innovation policy in Europe (7th Framework Programme) and TU Delft sustainable development focus (CleanEra, Cost-Effective Low emission And Noise Efficient regional Aircraft) at Aerospace Engineering. To achieve this step it is required that such new-generation diagnostic approach by the Tomo-PIV technique is further developed into a quadri-dimensional measurement tool (4D-PIV), enabling to extract the relevant acoustic information from the experimental observation invoking the aeroacoustic analogies. A wide industrial and academic network (DLR, AIRBUS, DNW, NLR, LaVision, EWA, JMBC Burgerscentrum) de