RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enhancing Programmability and boosting Performance Portability for Exascale Computing Systems' (EXA2PRO).

assistant: **Concept**

The vision of EXA2PRO is to develop a programming environment that will enable the productive deployment of highly parallel applications in exascale computing systems. EXA2PRO programming environment will integrate tools that will address significant exascale challenges. It will support a wide range of scientific applications, provide tools for improving source code quality, enable efficient exploitation of exascale systems' heterogeneity and integrate tools for data and memory management optimization. Additionally, it will provide various fault-tolerance mechanisms, both user-exposed and at runtime system level and performance monitoring features. EXA2PRO will be evaluated using 4 use cases from 4 different domains, which will be deployed in JUELICH supercomputing center. The use cases will leverage the EXA2PRO tool-chain and we expect: - Increased applications performance based on EXA2PRO optimization tools (data and memory management)- Efficient exploitation of heterogeneity by the applications that will allow the evaluation of more complex problems.- Identification of trade-offs between design qualities (source code maintainability/reusability) and run-time constraints (performance/energy consumption). - Evaluation of various fault-tolerance mechanisms for applications with different characteristics. EXA2PRO outcome is expected to have major impact in a) the scientific and industrial community that focuses on application deployment in supercomputing centers: EXA2PRO environment will allow efficient application deployment with reduced effort. b) on application developers of exascale application: EXA2PRO will provide tools for improving source code maintainability/reusability, which will allow application evaluation with reduced developers' effort. c) on the scientifi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Urban pressure on rural areas : mutations and dynamics of periurban rural processes' in the context of a Fifth Framework call.

assistant: **Objectives**

Per urbanisation from the rural point of view is an important question which to date has been studied from the urban point of view only, and not on the European scale. It questions on economic and social mutations within in these rural areas under urban pressure. It raises also the problem of the future of agriculture and competition for land. The research proposes here to characterise the dynamics involved, first of all by characterising the existing forms of per urbanisation and secondly by carrying out comparative analysis on the urban processes at work and rural proper dynamics. To achieve those objectives 6 work packages are planed. They will lead to two types of results, quantitative ones with a typology of diversity of per urban areas, qualitative ones with the characterisation of transformations and emerging conflicts. NEWRUR will propose new tools and recommendations to assist in implementing specific policies territorially suited
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fish and flavonoids' in the context of a Sixth Framework call.

assistant: **Objectives**

With the recent ban on the use of compounds such as malachite green in food fish production, there is an urgent need to find suitable efficacious compounds to control certain fish pathogens. There is also a need to improve fish health and reduce the dependency on drugs by assessing the utility of natural products as possible replacements. One potential group, the bio-flavonoids, comprise a vast array of biologically active compounds that are ubiquitous in plants. They display an incredible array of biochemic al and pharmacological actions (anti-inflammatory, anti-oxidant, anti-allergic, anti-viral & anti-carcinogenic).Their use in human and veterinary medicine (e.g. to control viruses in HIV/AIDS patients, in the study of coronary and circulatory disease and, as a topical spray to control MRSA in hospitals) is being actively researched. Unfortunately, almost nothing is known of the action of bioflavonoids on the immune system of fish. The project will assess the efficacy of selected bioflavonoids, as potential biocides and immuno-stimulants, in their ability to control bacterial and protozoan parasitic infections following experimental challenge.The project will screen a large number of bioflavonoids in vitro against several main fish pathogens to assess their biocidal activity before testing the most promising candidates in vivo to ascertain if they also have an immunostimulatory effect. The pathogens that will be screened include the pathogenic bacteriums Vibrio anguillarum, Aeromonas hydrophila and Renibact erium salmoninarum, the causative agent of Bacterial Kidney Disease, a notifiable fish pathogen within Europe.Their efficacy against the parasitic protozoan Ichthyophthirius multifiliis one of the most pathogenic diseases of freshwater fishes will also be tested.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'FABrication of 3D metasurfaces to enable the next generation of high efficiency optical products' in the context of a Horizon Europe call.

assistant: **Objectives**

FABulous will develop an industrial surface ‘coating’ technology that exploits breakthroughs in multiphoton lithography and process modelling to manufacture high resolution 3D metasurfaces at a throughput viable for series production. These metasurfaces will be capable of manipulating light with unprecedented flexibility and will open the possibility of designing and manufacturing smaller, lighter, and more environmentally friendly products, through the replacement of bulky components and/or the chemical coatings currently used to enhance the efficiency and performance of optical products.  The project will explore novel methods for rapid (>10cm2/min) micro-fabrication of high-resolution (smaller than 200nm) 3D structures, and the development of new production tools to optimise the design and integration of the metasurfaces into functional products. These innovations will then be scaled for commercial applications and integrated into an industrial platform with a quality assurance and control system, enabling the fabrication of 3D metasurfaces on a range of substrates with unprecedented productivity, resolution, flexibility, and reliability. The application of the technology and its potential to contribute to the design and manufacturing of more sustainable and circular European goods will also be demonstrated in a series of uses cases. The platform will be used to coat optical components (lenses, light pipes, and micro-optics arrays) with custom metasurfaces, and demonstrate that these components, when integrated into the design and manufacturing of functional optical systems (cameras, automotive lights and PV cells), can significantly improve their efficiency whilst in parallel reducing their environmental footprint.


**Keywords:** Metasurface, Multiphoton Lithograph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ToWards the Identification of Sesquiterpene TransportERs' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Plants synthesize a wide range of secondary metabolites, among them, terpenes. These molecules are notably produced in trichomes which are specialized structures present on the surface of aerial organs. Although the terpene biosynthetic pathways have been well deciphered, their transport across membranes remains poorly understood. This is for instance the case for sesquiterpenes such as artemisinin, an extremely potent anti-malaria drug. Despite the immense benefits of these compounds for plant defenses as well as for human health, no sesquiterpene transporters have yet been identified.It was recently shown that Pleiotropic Drug Resistance (PDR) transporters, which belong to the large ATP-Binding Cassette family, are involved in diterpene transport in Nicotiana tabacum trichomes. Thus, other PDR transporters could transport other types of terpenes such as sesquiterpenes.Recently, two PDR transporters of Artemisia annua, namely AaPDR1 and AaPDR2, have been shown to be specifically expressed in glandular and T-shaped trichomes, respectively. Interestingly, glandular trichomes are known to produce artemisinin while T-shaped trichomes have been shown to produce ß-caryophyllene. Thus, we can hypothesize that AaPDR1 and AaPDR2 transport dihydroartemisinic acid, the artemisinin precursor, and ß-caryophyllene, respectively.In order to examine this hypothesis, this project aims to express these transporters in N. tabacum BY2 cells and characterize their activity using toxicity and transport assays in whole cells as well as direct transport in plasma membrane vesicles. In case our hypothesis concerning the substrates is incorrect, we will rely on a transportomics approach, which consists of running transport assays using metabolites extracted from isolated trichomes as putative s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Processing and Irradiation Defect Engineering in Advanced CMOS Technology' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The overall objective is to built up expertise in the field of material science related to deep sub micron CMOS processing and to investigate the irradiation hardness of these technologies. This requires a clear understanding of different disciplines such as material characterization, defect studies, silicon processing, and electrical device characterization and irradiation studies. Due to the large number of processing steps in CMOS technology it is essential to either remove the process-induced defects or at least drive them towards the inactive regions of the components. This control effort is called defect engineering and guttering. Beside the process-induced defects, additional defects can also be created during the device operation having direct consequences on the lifetime of the components. The space community is more and more using the Commercially-of-the-Self (COTS) approach. This means that instead of dedicated components, fabricated in hardened technologies, commercial parts fabricated in mainstream CMOS are used for space electronics. Increasing the lifetime of components will reduce the cost, save energy and reduce the emission of greenhouse gases. A fundamental study of the nature and structure of such defects is thus necessary to advance in technological applications, in particular in the miniaturization of components. For the applicant it is a unique opportunity to work on state of the art research topics, for which there is world- wide large interest. The proposed research plan is covering a broad range of topics, combining activities on material science, silicon processing and irradiation physics. It also allows building up expertise on how to conduct a large joint research program in an international environment. The training will not only be perform
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Assistive technology cluster for quality of life' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

European aging population has placed new demands on family units and raises pressing questions about the efficiency and management of care and support technologies and services for dependent people. Assistive technologies will play a key role in social inclusion, independency and autonomy of elderly people and disabled people, transforming the research activities in assistive technologies in the real solution to everyday life people in real conditions.  General objective: to set the basis for the creation a new research driven cluster on assistive technologies (AT) in San Sebastián to improve the coordination of the local stakeholders working in the field and maximise the efforts and existing infrastructures for improving socioeconomic development and strengthen the RTD and innovation capacity of the city, and also acting as facilitator and catalyst at regional level.   The project is structured in 9 workpackages. The mentoring of EU experts in AT along all the project duration has been envisaged in WP1, for ensuring that key documents developed in the project are relevant and consistent. Additionally, WP2 and WP3 will consider the framework in which assistive technology sector has developed for having an overall vision on the initiatives boosted from the public administrations and the evolution of AT technology market. Furthermore, the local economic and RTD potentiality of San Sebastián will be analysed in WP4. The focus of WP5 will be to mobilise the local stakeholders in order to extract jointly agreed, contrasted and validated the Cluster Research Agenda and Implementation Plan that will elaborated in parallel respectively in WP6 and WP7.   Finally, WP8 will focus on the dissemination of the results achieved in the project and WP8 will ensure the correct management
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'MARITIME JUST-IN-TIME OPTIMIZATION INTEROPERABLE PORT CALL AND VOYAGE OPTIMIZATION TOOL'.

assistant: **Objectives**

Delays within the maritime supply chain can lead to a “hurry-up-and-wait” syndrome of vessels sailing at a predetermined speed to their destination port to find the terminal or port not ready thus waiting at anchorage in the port area. Updated information about current states are not communicated to all partners in the different port call phases. This makes traffic of vessels waiting, entering, and departing from ports challenging. Communicating terminal or port readiness earlier to vessels allows them to adjust speed and save fuel of up to 23% of the overall voyage including the avoidance of greenhouse gas emissions.  The average annual waiting time at anchorage is found to be ca. 9% for wet bulk, ca. 9% for dry bulk, ca. 7% for LPG tankers, ca. 7% for dry breakbulk, ca. 5% for container ships, and ca. 4% for LNG tankers. RoRo-vessels benefit from less traffic-condensed port entries and seaways as well as transparent real-time communication of readiness levels regarding ports and terminals as well as multi-modal hinterland transportation critical for RoRo-port departures. MISSION will develop an interoperable digital real-time-based optimization and decision support tool enabling coordinated port call operations planning and execution in terms of time, fuel consumption, environmental impact, and safety spanning the overall maritime supply chain. Stakeholders benefits from increased transparency and information sharing between shipping companies, terminals, ports, and service providers, enabled to optimize their resource and capacity planning including port’s hinterland modalities in compliance with the Maritime Labor Convention.


**Keywords:** Port call optimisation, GHG emissions reduction, fuel consumption, port operations, analytics, IT systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mechanical sensing and reprogramming of CAR-engineered lymphocytes for next-generation ACT cancer immunotherapy' (MechanoCAR) targeting Horizon Europe.

assistant: **Abstract**

Adoptive cell transfer (ACT) with cytotoxic lymphocytes, including chimeric antigen receptor (CAR)-T cells, is a powerful immunotherapy already demonstrating remarkable success against certain blood cancers. However, its efficacy in treating solid tumors remains limited, with durable responses being rare. Current strategies to improve ACT therapy focus predominantly on biochemical interactions between immune cells and cancer cells. Yet, emerging evidence highlights the significant influence of biomechanical cues in shaping immune responses and therapeutic outcomes. For instance, the mechanical properties of cancer cells, such as cellular softness, can confer resistance to immune cell-mediated killing, while rigidifying cancer cells can sensitize them toward immune attack leading to enhanced immunotherapy.         MechanoCAR explores a novel, under-explored approach: mechanical reprogramming of cytotoxic lymphocytes, including CAR-T and CAR natural killer (NK) cells. We hypothesize that enhancing the mechano-sensitivity of the lymphocytes could overcome some of the key limitations of ACT therapies, particularly against resistant tumors. First, we aim to uncover and characterize the mechano-sensing and mechano-transduction mechanisms of CARs. Next, we will develop and test innovative mechanical reprogramming strategies to enhance the cytotoxic potential of CAR-T/NK cells in advanced tumor models and further explore the therapeutic potential using patient-derived organoids.         This ambitious and high-reward research has the potential to transform ACT cancer immunotherapy. It addresses significant gaps in current biochemical-centric approaches by introducing a new paradigm focusing on mechanical modulation. If successful, it will provide groundbreaking insights into me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Genes, Policy, and Social Inequality' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Many important indicators of social status (such as ones level of education, occupation, and income) have been shown to be moderately heritable, meaning that a part of the variation in social status can be explained by genetic differences across population members. I have been able to identify for the first time specific genetic variants that are robustly associated with such an indicator, namely educational attainment (Rietveld et al., 2013, Science). By methodologically advancing the estimation of the interaction between genes and environments, this proposal will settle two long lasting debates in social science genetics.First, I will show how heritability studies despite earlier firm rejections of this position can be informative for policies aiming to reduce social inequalities (Objective 1). Second, I will assess the critique that social science genetics attributes effects to genes which should be attributed to the environments through which these genes operate (Objective 2). In doing so, I will extend existing methodology to quantify the incremental explanatory power of genes over environmental factors such as the social status of parents (Objective 2A), and I will develop a solution for the endogenous inclusion of environmental factors in genetic summary indices (i.e., polygenic risk scores) which currently impacts the validity of gene-by-environment studies (Objective 2B).All newly developed methods will be tested extensively using simulations, and made available for others by means of free software code. Empirically, I will interact genes and various natural experiments (policy changes) to identify interventions that can ameliorate social inequalities in terms of education, occupational status, and income. For this purpose, I will draw on a unique combination o