RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'The development of predictive tests of normal tissue response to radiation therapy'.

assistant: **Objectives**

The aim of this concerted action is to bring together the intellectual and technical resources of 14 research groups within Europe to develop methods by which the patients, most at risk, of radiotherapy complications can be identified.The success of curative radiotherapy depends critically on those patients who are most at risk of dose-limiting complications. At the present time, the standard approach for radiotherapy with curative intent is to prescribe the maximum dose that is judged by the radiotherapist to be within the limit of normal-tissue tolerance. This dose is chosen on the basis of clinical experience to be one that will not lead to serious complications in more than a few percent of cases. This project foreshadows an important change in the strategy of radiation therapy : the individualisation of dose prescription. Tissue and blood specimens will be taken before treatment begins and subjected in the laboratory to a series of tests aimed at achieving the best possible prediction of normal-tissue tolerance to radiation therapy. On the basis of these tests we aim to identify that sub-group of patients who are most at risk of damage. Two principal options will then become available to improve patient management : to reduce the intensity of treatment for the patients who are most at risk of damage, and to increase the intensity of treatment for the majority of patients, thereby increasing their likelihood of achieving local tumour control. Patients who suffer complications of radiotherapy fall into 3 groups : those who show a severe early reaction to irradiation; those who show a level of late radiation damage that stands out as being excessive; and those who suffer early tissue effects that are so severe that treatment has to be curtailed. The first 2 categories
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Plants in the ancient Near Eastern texts. A transdisciplinary analysis of the human-plant relations in Mesopotamia during the Neo-Assyrian and Neo-Babylonian periods' in the context of a Horizon Europe call.

assistant: **Objectives**

PlANET project aims to reconsider the role of ten plant species in Mesopotamia during the Neo-Assyrian and Neo-Babylonian periods (10th–6th cent. BCE) in religious, ideological, scholarly, gender, and economic spheres. It aims also to prove cases of human overexploitation of plant resources causing ecological traps, whose long-term effects are still experienced today. The project is the first full-scale study permitting us to dramatically increase our knowledge of Mesopotamian human-plant relations, by producing an innovative transdisciplinary non-anthropocentric paradigm, involving the methods of historical-philological and anthropological research, the archaeobotanical literature and the tools of Digital Humanities. It will set up an open-access database offering a systematic integration of textual data and archaeobotanical information to establish links between plant emic names, identifications, and activities described in textual sources. Such data variety will be analyzed in the light of Ecological Anthropology and Environmental Humanities. This holistic approach will make the outcomes relevant to a broad academic community since the addressed questions and methodologies can be used in other research fields, regions, and periods. The Dep. SARAS (Sapienza) and NELC (Penn) are the perfect places to acquire new multidisciplinary skills (study of cuneiform economic texts, Digital Humanities, and archaeobotany) and to open significant future academic career paths. SARAS has an anthropological section, while NELC collaborates with the Penn Museum, crucial to the successful implementation of the project. The results will be disseminated and communicated through various channels and audiences (online database, scientific works, statement for Iraqi Ministry of Environment,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced PRocedures for volcanIc and Seismic Monitoring' under Seventh Framework.

assistant: **Concept**

APHORISM project proposes the development and testing of two new methods to combine Earth Observation satellite data from different sensors, and ground data. The aim is to demonstrate that this two types of data, appropriately managed and integrated, can provide new improved Copernicus products useful for seismic and volcanic crisis management.The first method, APE – A Priori information for Earthquake damage mapping, concerns the generation of maps to address the detection and estimate of damage caused by a seism. The use of satellite data to investigate earthquake damages is not an innovative issue. We can find a wide literature and projects concerning such issue, but usually the approach are only based on change detection techniques and classifications algorithms. The novelty of APE relies on the exploitation of a priori information derived by InSAR time series to measure surface movements, shakemaps obtained from seismological data, and vulnerability information. This a priori information is then integrated with change detection map to improve accuracy and to limit false alarms.The second method deals with volcanic crisis management. The method, MACE - Multi-platform volcanic Ash Cloud Estimation, concerns the exploitation of GEO (Geosynchronous Earth Orbit) sensor platform, LEO (Low Earth Orbit) satellite sensors and ground measures to improve the ash detection and retrieval and to characterise the volcanic ash clouds. The basic idea of MACE consists of an improvement of volcanic ash retrievals at the space–time scale by using both the LEO and GEO estimations and in-situ data. Indeed the standard ash thermal infrared retrieval is integrated with data coming from a wider spectral range from visible to microwave. The ash detection is also extended in case of cloudy a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dependability Benchmarking', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The objective of DBench is to define and validate dependability benchmarks for largely deployed computer systems. We consider specifically COTS and COTS-based systems, due to their widespread use in this kind of systems.Four major steps are planned:1) definition of the conceptual framework for system benchmarking;2) identification and evaluation of the enabling technologies;3) specific benchmark definition and application to pilot experiments in order to develop, experiment and validate the benchmark prototypes and;4) consolidation of the conceptual framework with the experimental results.The pilots are central in assessing and supporting the results of the development of the enabling technologies and of the benchmark guidelines that will be provided at the end of the project with the benchmark prototypes. Two major application areas are considered, embedded systems and transactional applications, and the benchmark prototypes will be implemented in two COTS OS (Windows and Linux).Objectives:The DBench project will define a conceptual framework and an experimental environment for benchmarking the dependability of COTS and COTS-based systems.It will provide system developers and end-users with means for:1) characterising and evaluating the dependability of a component or a system;2) identifying malfunctioning or less weak parts, requiring more attention;3) tuning a particular component to enhance its dependability and;4) comparing the dependability of alternative or competing solutions.The two final measurable objectives that will be achieved at the end of the project are a report presenting the concepts, specifications and guidelines for dependability benchmarking and a set of dependability benchmark prototype tools. The prototypes will be made widely available (e.g. thr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Municipal Action, Public Engagement and Routes Towards Energy Transition' to be submitted under Horizon 2020.

assistant: **Abstract**

mPOWER will enable in-depth, wide-scale and systematic peer-to-peer learning  programme between at least 100 local public authorities with a view to replicate innovative best practice in municipal energy. European cities, particularly in Germany, Denmark and France, are municipal energy innovators running distribution networks, supply companies, renewable generation, citizen participation processes and finance for energy projects. Other cities across Europe are investigating their options for municipal energy and are looking to learn.mPOWER will map existing municipal energy policy and identify innovations, best practice, as well as obstacles and barriers. The action will enable participant authorities across Europe to (a) learn from replicable best practices, (b) recognise risks, obstacles and blockages, (c) identify and commit to replication pathways that best suit local needs, (d) incubate at least 30 new and improved municipal energy policies and projects within the project duration. Lessons learnt will be disseminated publicly and through target networks in easily accessible format for replication.30 cities and city networks from 14 Member States have already expressed interest in participating.An estimated 3.9GWh/year can be saved and 40.8GWh/year renewable capacity installed through replicating practices between participant cities within the action (respectively 9.8GWh/year and 108.8 GWh/year within three years of project end). This can be scaled up around Europe through wider replication, promoted by Energy Cities and partners beyond the project’s lifetime.mPOWER’s project consortium brings access to an active network of cities committed to energy transition (Energy Cities, IPE), experience in energy policy (Platform, Energy Cities, IPE) and energy innovation (C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Combining optoacoustic imaging phenotypes and multi-omics to advance diabetes healthcare' (OPTOMICS), addressing dissemination and exploitation.

assistant: **Impact**

Diabetes has emerged as a global pandemic affecting more than 420 million people worldwide, a number expected to further rise in the next decades. The disease has very heterogeneous outcomes and accurate patient staging or prediction of subsets of individuals likely to develop disease and/or progress to disease complications are currently unmet clinical challenges in need of urgent attention. OPTOMICS aims to research methodology that can deliver a paradigm shift in type 2 diabetes healthcare, by integrating 1) molecular phenotyping, 2) a new generation of phenotypic measurements in humans, representative of diabetes onset and progression, allowed by novel portable and non-invasive optoacoustic technology and 3) cutting-edge computational approaches leveraging progress in Artificial Intelligence. This research will develop and validate a digital twin model that catalyses a step change in shortening the path to translation, enabling applications in the entire spectrum from target identification & prevention/prognosis to patient stratification for type 2 diabetes and its complications. In addition to the research and technology goals, OPTOMICS places special attention to the ethical needs and implications of the work performed and further aims at exemplary project management, human measurements, dissemination and communication activities and updating an adept exploitation plan for the digital twin developed.


**Keywords:** diabetes, proteomics, metabolomics, genotyping
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deciphering the roles of reactive oxygen species and calcium during viral infection in Arabidopsis' to be submitted under Horizon Europe.

assistant: **Abstract**

As sessile organisms, plants always have to deal with different environmental stimuli. The generation of reactive oxygen species (ROS) and calcium flux as second messengers are one of the common strategies to respond to such stimuli. Upon perception of pathogens, molecular warning signals (ROS and calcium) propagate cell-to-cell to trigger defence mechanisms. However, the precise roles of ROS and calcium during viral infection process and the associated signalling mechanism remain largely unknown. Viruses are obligate intracellular pathogens that hijack host machineries to facilitate their replication and propagation across the plant through plasmodesmata, communication channels bridging the plant cells. The ViROSCa project’s goal is to explore the mutual role of generated ROS and calcium signals and to study the crosstalk between the two signals during viral infection and later identify the virus element(s) that specifically induce(s) such signals. I will integrate Arabidopsis genetics, biosensors, genome editing technology (CRISPR/Cas9) and advanced microscopy techniques to decipher the roles of plasma membrane (PM)-located ROS- and calcium related candidate proteins and PM organisation (nanodomains) during the plant virus infection process. The novelty of the project is the use of a powerful pathosystem and biosensors to study the crosstalk between ROS and calcium signalling.


**Keywords:** Reactive oxygen species, Calcium, Plant viruses, Nanodomains and Biosensors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Thymopoiesis: From Evolutionary Origins to Future Therapies' (EVOTHYME), addressing dissemination and exploitation.

assistant: **Impact**

The role of the thymus in cell-mediated immunity was discovered about 50 years ago and it has since become apparent that the thymus is the site of T cell development in all extant vertebrates. Although it has been recognized that thymopoiesis can only be fully understood by the analysis of both the thymic epithelial microenvironment and the intrathymic haematopoietic compartment, significant gaps in our knowledge of thymopoiesis remain.The proposal addresses major biological questions of thymopoiesis in a novel way. It is based on an evolutionarily informed approach that makes iterative use of distinct animal models (fish and mouse), and additionally considers information obtained from the analysis of human patients with thymopoietic deficiencies. The proposal aims to develop an animal model conducive to transplantation of xenogeneic haematopoietic progenitor cells. This system will be used for subsequent analysis of haematopoietic and immunological properties of genetically intractable fish species. The proposal also aims to determine the structure of genetic networks underlying the development and function of thymic epithelial cells and intrathymic T cell differentiation. This information will be used to explore the possibility of alleviating the phenotypic consequences of disease genes by interfering with the function of genes situated elsewhere in the respective genetic networks rather than by restoring faulty gene function. Evolutionarily constrained inventories of such genetic networks will be additionally used for the design of synthetic thymopoietic environments in non-cognate tissues, either using combinations of thymopoietic factors or by exploiting the thymopoietic capacity of Foxn1, a master regulator of thymic epithelial cell differentiation. Overall, the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A cutting edge integrated approach to sperm biology and associated reproductive biotechnologies to assist the dairy and beef industries meet growing societal, environmental and economic demands' (BullNet) targeting Horizon Europe.

assistant: **Abstract**

BullNet, consisting of 8 beneficiaries and 13 associated partner organisations, will build a multi-disciplinary and inter-sectorial research programme designed to unravel the complex underlying biology of compromised fertility of individual bulls. Cutting-edge basic, applied and machine-learning approaches will be used to deliver a robust, flexible semen product from young, appropriately reared and managed, first-season elite sires that can be used successfully for artificial insemination (AI) with predictable and consistent fertility, so as to provide the industry with key tools to meet current emissions and animal welfare demands. BullNet will also lead to the advancement of knowledge in how bull management strategies and semen processing affect the functional and molecular characteristics of sperm, thus opening scientific horizons for new applications in the area of assisted reproduction. The overall aim of this programme is to train a new generation of creative, entrepreneurial and innovative doctoral candidates (DCs) in the area of bull fertility. BullNet will expose DCs to different sectors and they will acquire a comprehensive set of transferable skills working in the specific research area relating to their individual research projects, with an emphasis on the need for technology transfer from academic institutions to commercial users. Moreover, given the wide range of academic and industry organisations involved, the DCs will be able to face current and future challenges in order to convert knowledge and ideas into products and services for economic, technological and societal benefit.


**Keywords:** bull, reproduction, sperm, epigenetics, embryo, machine learning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Pilot-study for a human epigenome project'.

assistant: **Objectives**

For an elucidation of complex human disease, all available sources of biological information are required. Biological information sources are DNA, mRNA, proteins, metabolic networks and epigenetic information in the form of chromatin structure and DNA-methylamine. DNA-methylamine is tissue specific and correlates with gene- expression, hence being a likely contributor to pathogenesis. The pilot-project proposed will demonstrate the methylamine blueprint of two different human tissues for a selected 4 Mb genomic region, the Major Histocompatibility Complex (MHC) by genomic sequencing. The MHC is the most polymorphism genomic region known, the densest in genes and displays association with a number of diseases. In addition, correlations between heliotypes associated with Psoriasis, an MHC-linked disease and methylamine epigenotypes will establish reproducible inter-individual, disease related variation of methylamine patterns.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Fabrication of three dimensional magnetic nanowires for information storage' (3DMAGNANOW) targeting Seventh Framework.

assistant: **Abstract**

The objective of the proposal is the fabrication and study of three dimensional (3D) magnetic nanowires for ultra-high density information storage. Current memory architectures are 2D, composed of one layer of active components. The extension of data storage devices into the third dimension could result in information densities of hundreds of Gb/in2, causing a technological revolution. The project aims at implementing a 3D version of the existing 2D host institution’s idea of domain wall based shift registers to store data. In this scheme, the data bits are stored using the two possible directions of the magnetisation in thin and narrow nanowires made of soft ferromagnetic materials. The fabrication of the 3D devices will be done by using a novel promising nanolithography technique: focused electron beam induced deposition (FEBID), with unique capabilities for the creation of 3D nanostructures. We have recently demonstrated the required possibility to control domain walls in cobalt nanowires created by this technique. The patterning of magnetic nanostructures by means of conventional lithography, such as electron beam lithography and ion milling, will be explored in parallel. The control of the domain walls will be probed by magneto-optical magnetometry and magneto-electrical measurements. The two directions to be investigated for the creation of 3D magnetic devices will be the stacking of 2D magnetic nanowires, and the direct fabrication of 3D nanowires. The host group possesses patents protecting the ideas presented in this proposal. The success of the project would place the European Union in a privileged position to lead the next steps in the development of Information Technology.