RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Signaling dynamics in the control of cell proliferation and differentiation during development and homeostasis' (SignalingDynamics) under Horizon 2020.

assistant: **Objectives**

Tight coordination between proliferation and differentiation is key to proper development and homeostasis of multicellular systems. Cell-cell communication via signaling pathways has long been studied in this context. Encoding information in the temporal change of a signal, i.e. signaling dynamics, can ensure information transmission to be specific and accurate. Studies exemplifying the relevance of dynamic signaling raise the critical question: What is the function of signaling dynamics in controlling proliferation and differentiation at tissue level? My expertise in signaling dynamics, advanced light microscopy, microfluidics, development, cell cycle research and organoid culture provides a unique skill-set for the functional investigation of dynamic signaling during development and tissue homeostasis using two model systems:Somitogenesis in vertebrate embryos is the sequential segmentation of growing tissue. It is controlled by signaling gradients and oscillations. Whereas differentiation has been studied extensively, it remains elusive (A) how cell proliferation is regulated and (B) whether there is a link between proliferation and signaling dynamics. Indeed, our preliminary data strongly indicate that cell proliferation impacts on signaling oscillations. Homeostasis of adult tissue is also maintained by signaling pathways balancing proliferation and differentiation. In the small intestine some of these pathways have recently been shown to be dynamic. We will apply a systematic approach to understand (A) are signaling pathways in the intestine dynamic and (B) what is the function. Our preliminary data support that combining organoid culture, light-sheet microscopy and microfluidic perturbation allows quantification and functional analysis of signaling dynamics.By co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Genetical characterization of the putative hemolysins/cytolysins of mycobacterium avium' in the context of a Fifth Framework call.

assistant: **Objectives**

Two strategies will be used for cloning of M. avium genes encoding hemolytic factors. The first one will take advantage of DNA-DNA homology with sequences of other bacteria. In the second one, a genomic library will be screened for hemolytic colonies on blood agar plates.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mechanisms of Intercellular Signalling in Alzheimer's Disease : The Role of Apolipoprotein E' in the context of a Fourth Framework call.

assistant: **Objectives**

Elucidation of the role of apo E and its receptors in inter- and intracellular signalling within the AD brain. Given that apo E has a crucial role in the local redistribution of lipids during nerve injury and repair, the research will unravel major aspects of the pathophysiology of central nervous tissue damage and regeneration. The role of lipoprotein receptors and lactoferrin will address immunological mechanisms of neurological disorders.To elucidate pathogenesis of Alzheimer's disease, advantage is taken of the participants expertise in lipoprotein metabolism, brain cell metabolism and signal transduction in nerve cells. The factors governing the regulation of the expression of apoE (and variant forms E2, E2, and E4) in astrocytes will be explored. A set of cells to be characterised for apoE metabolism and the receptors therefore (C6 glial cells, a glia-like cell line (U373)) and astrocyte rich primary cultures, neuron like cell lines (PC12), hNT-neurons and hippocampal neurons of Banker-cultures will be characterised and distributed.These tools will be used to characterise in detail the interaction of variant forms of apo E with constituents of the extracellular matrix in the nervous system such as A4/beta and heparan sulphate proteoglycans. They will allow to define the receptor mediated pathways and their regulation serving the delivery of variant forms of apo E into glial and neuronal cells. As a result the effects of variant forms of apo E on the processing of normal and mutant amyloid precursor proteins as well as possible intracellular effects of apo E on the structure and function of the cytoskeleton, can be elucidated. Results hinting that apo E variants differentially influence neuronal survival will finally direct research towards therapeutic studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'In depth analysis of the role of essential kinases in regulation of meiotic chromosome segregation in Schizosaccharomyces pombe' (AEKSP) under Seventh Framework.

assistant: **Objectives**

Meiosis is a specialized cell cycle that enables diploid organisms to reproduce sexually by generating haploid gametes through two succesive divisions. To depict the detailed regulatory mechanism of meiotic chromosome segregation, the relevant proteins need to be identified and characterized. Protein kinases play important role and regulate multiple biological processes, including meiosis. Up to now, several kinases have been shown to be implicated in regulation of meiotic chromosome segregation. However, some kinases are essential for mitotic growth, a fact that precluded their detailed analysis in meiosis.Recently, we applied high-throughput knockout and chemical genetic strategies to construct the conditional analog-sensitive mutants of all known Schizosaccharomyces pombe essential kinases. Inhibition of particular kinases during meiosis and analysis of meiotic chromosome segragation in these mutants revealed that eight of these kinases play essential role for faithful chromosome segregation.The proposed project aims to analyze in more detail the molecular functions of selected essential kinases and define how these kinases regulate meiotic chromosome segregation. To elucidate the regulatory functions of these kinases, their role in meiotic recombination, in mono-orientation of sister kinetochores and in protection of centromeric cohesion will be analyzed. In addition, the proteomic approach will be applied to gain further insights into the kinases functions through identification of kinases targets and their postranslational modifications.In regard to the proposed project, the expected results could help us to better understand the molecular mechanism how chromosome segregation is regulated during meiosis and in the long-run also the principles of gametogenesis as w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Quantification of Past Ocean Circulation' (OCEANQUANT), addressing dissemination and exploitation.

assistant: **Impact**

Global warming is expected to critically affect human society, economic growth and biodiversity. In order to better predict future changes of the climate system and to potentially develop adaptation and mitigation strategies, modern science has been looking back to the past to assess the feedback reactions of the global climate system under varying boundary conditions. However, incomplete understanding of the quantitative role of physical and biogeochemical mechanisms hinders comprehensive models to reliably simulate past climate variability, thereby hampering robust predictions of the future evolution of the climate system.The meridional overturning circulation of the oceans plays an instrumental role in modulating climate by storing and redistributing heat, salt, carbon and nutrients around the planet. This proposal focuses on investigating the interactions between climate and ocean circulation, as gleaned from the testimony of paleoceanographic records. These records extend beyond the noise of recent decadal oscillations, to provide an independent perspective on the links between climate and ocean dynamics.Former studies found significant re-organisations of ocean dynamics during the last glacial cycle, but were not able to provide robust, quantitative estimates of past changes in ocean circulation. This research proposal aims at providing transformational constraints on the role of the ocean in driving climate change. The innovative dimension of the proposed research resides in the combined approach involving cutting edge analytical techniques and state-of-the-art model simulations. The proposed research will provide unprecedented quantitative, large-scale estimates of past changes in ocean circulation enabling more reliable predictions of future climate change.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fate mapping of precursor cells following CNS demyelination' under Sixth Framework.

assistant: **Concept**

Remyelination, the process by which new myelin sheaths are restored to demyelinated axons, is an unusual example of a regenerative process in the adult mammalian CNS, and is mediated by newly generated oligodendrocytes. These cells are derived from precurs or cells. However, two issues remain unresolved: 1) which precursor cells give rise to oligodendrocytes, and 2) are these cells multi-potent following demyelination, giving rise to cell types other than oligodendrocytes? To address these issues this project will use cre-lox technology in which stage specific promoters will be used to express an inducible Cre (Cre-ER) and thereby activate expression of marker genes. This will enable identification of precursor cells and the cells into which they differentiate following CNS demyelination.We will use mice in which Cre is expressed using the promoter for PDGFRa, a gene exclusively expressed by oligodendrocyte precursor cells in adult white matter. Since remyelinating cells may come from other populations of precursors that do not express PDGFRa, we will also use mice in which Cre expression is controlled by PLP, a gene expressed more widely by cells of the oligodendrocyte lineage. Both these mice are available to the host laboratory. Focal areas of demyelination will be created in spinal cord white matter by injection of lysolecithin or in corpus callosum by dietary administration of cuprizone. The identity of marker gene expressing cells occurring in response to demyelination and will be established by immunocyto chemistry or in situ hybridisation for oligodendrocytes, astrocytes, Schwann cells and neurons.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards standardized 6G connectivity for ambiently-powered energy neutral IoT devices' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Internet of Things (IoT) technology is widely recognised as having the potential to tackle some of the world’s biggest challenges. However, to truly benefit society and enable a sustainable future, IoT innovations will need to address the technology gap that exists in powering the rising number of IoT devices. Specifically, the AMBIENT-6G consortium argues that it will be impossible to power hundreds of billions of future IoT devices with batteries that need to be replaced or recharged manually. The maintenance costs, environmental impact, and safety hazards will just be too high. Instead, AMBIENT-6G proposes a new class of energy-neutral devices (ENDs) that will be connected to the IoT through novel ultra-low-power 6G technologies. ENDs exploit ambient energy harvesting or wireless power transfer to recharge their storage and power their operations, allowing them to achieve decades-long energy autonomy. The overall objective of AMBIENT-6G is to design, prototype, validate, and standardize hard- and software technology solutions for intelligent ENDs, and the 6G network infrastructure that connects them to the Internet. To achieve this objective, the project will provide technological innovations in terms of (i) END hardware and software components to enable energy harvesting and management, as well as backscatter and active wireless communications, (ii) a new 6G low-power wide area network technology with significantly lower energy consumption than current technologies, and (iii) machine learning both on-device and orchestrated along the Cloud-Edge-Device continuum to support intelligent management of the device and network resources, as well as local application data processing. AMBIENT-6G will maximize the impact of the above innovations by actively participating in 3
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'An Information Theoretic Approach to Improving the Reliability of Weather and Climate Simulations' (ITHACA).

assistant: **Concept**

The aim of this project is to develop a new synergy between climate and computer science to increase the accuracy and hence reliability of comprehensive weather and climate models. The scientific basis for this project lies in the PI’s pioneering research on stochastic sub-grid parametrisations for climate models. These parametrisations provide estimates of irreducible uncertainty in weather and climate models, and will be used to determine where numerical precision for model variables can be reduced without degradation. By identifying those bits that carry negligible information – typically in high-wavenumber components of the dynamical core and within parametrisation and Earth-System modules – computational resources can be reinvested into areas (resolution, process representation, ensemble size) where they are sorely needed. This project will determine scale-dependent estimates of information content as rigorously as possible based on a variety of new tools, which include information-theoretic diagnostics and emulators of imprecision, and in a variety of models, from idealised to comprehensive. The project will contribute significantly to the development of next-generation weather and climate models and is well timed for the advent of exascale supercomputing where energy efficiency is paramount and where movement of bits, being the single biggest determinant of power consumption, must be minimised. The ideas will be tested on emerging hardware capable of exploiting the benefits of mixed-precision arithmetic. A testable scientific hypothesis is presented: a proposed increase in forecast reliability arising from an increase in the forecast model’s vertical resolution, the cost being paid for by a reduction in precision of small-scale variables. This project can be expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Graphene Based Ultrafast Lasers' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Manipulating structure and composition in the nanoscale allows the creation of novel materials with superior performance for new products and devices. The introduction of a wide range of new low-cost nanomaterials is expected to have a disruptive impact on a variety of conventional inorganic semiconductor devices, not only because of performance/cost advantages, but also because they can be manufactured in more flexible ways, suitable for a growing range of applications.Graphene, a single layer of carbon allotrope, exhibits extraordinary optical and optoelectronic properties for  ultrafast  broadband  photonics,  including  ultrafast  response,  high  mobility,  broadband  absorption,  and gate-variable optical conductivity, in addition to flexibility, robustness and environmental stability. My  proposal  aims  to  use  graphene  to  create  a  new  range  of  ultrafast  lasers,  such  as  ultrafast  fiber, solid-state, and waveguide lasers. These lasers will break the spectrum and speed bottleneck of existing devices, and thus can provide cost-effective, energy-saving and robust tools with unprecedented speed and bandwidth, ideally fitting a large range of growing and emerging applications, such as high-speed telecommunication, industrial material processing, metrology, medicine and sensing applications. This is an ambitious frontier research program, with a strong interdisciplinary nature, across Engineering, Physics, Chemistry and Matter sciences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Energy Demand Aware Open Services for Smart Grid Intelligent Automation' (SmartHG) targeting Seventh Framework.

assistant: **Abstract**

SmartHG will develop economically viable Intelligent Automation Software services gathering real-time data about energy usage from residential homes and exploiting such data for intelligent automation pursuing two main goals: minimise energy usage and cost for each home, support the Distribution Network Operator (DNO) in optimising operation of the grid. SmartHG rests on the following four pillars.<br/>First, Internet-based open standard protocols enabling effective communication between: i) home devices (e.g., sensors, smart appliances, local generators, electric vehicles, energy storage) and SmartHG services; ii) SmartHG services and DNO software systems; iii) any pair of SmartHG services. This will enable development of hardware device-independent energy services, possibly on the basis of the services already available.<br/>Second, user-aware SmartHG services focusing on residential homes. Such services will measure home energy usage and local generation (e.g., from renewable sources), forecast it and actuate home devices (both loads and generators) in order to minimise the home energy bill and usage (local optimisation) with respect to a given price policy computed to attain global (grid level) optimisation.<br/>Third, demand-side aware SmartHG services focusing on the grid. Such services will compute individual (yet fair) price policies for each single home taking into account user preferences while optimizing grid operations. Grid safety for such price policies will be formally verified using model-checking-based techniques. Furthermore, such SmartHG services will increase grid reliability by estimating and controlling (using price policies) voltages and currents in internal unmonitored nodes of the grid.<br/>Fourth, SmartHG case studies in Kalundborg and Minsk wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Does vascular endothelial growth factor gene therapy safely improve outcome in severe early-onset fetal growth restriction?' in the context of a Seventh Framework call.

assistant: **Objectives**

Fetal growth restriction (FGR) globally occurs in 8% of pregnancies, is severe and early onset in 1:500 cases, affecting 11,000 babies annually in the EU. In most cases, reduced uterine blood flow restricts substrate delivery to the fetus causing growth to slow or cease. There is no treatment. Currently the fetus is delivered very preterm before fetal death or irreversible organ damage occurs. Affected neonates suffer intracranial haemorrhage, chronic lung disease, cerebral palsy, with heart disease and diabetes as adults; mortality is high. Recent improvements in the care of premature growth restricted neonates, means that more of them survive delivery, but at great cost. Small increases in fetal growth and gestation at birth are associated with major improvements in survival and morbidity.Improving uterine blood flow is key and Vascular Endothelial Growth Factor (VEGF) is important to achieve this. In preclinical animal models we showed that local VEGF gene transfer to the uteroplacental circulation using adenovirus vectors increases uterine blood flow, attenuates constriction of uterine arteries and increases angiogenesis; these changes result in improved growth of severely growth restricted fetuses. This is the first clinically-applicable evidence based therapy that could improve perinatal outcome in severe early onset FGR in man.In collaboration with an SME experienced in gene therapy trials, our aim is to complete an agreed toxicology programme, identify specific ethical issues in stakeholders, and to perform a Phase I/II study in women with severe early onset FGR at four EU centres of excellence, using interventional radiology to deliver an adenovirus vector containing the mature processed form of human VEGF-D into the uterine artery. Data on safety, tolerability