RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'SIMPLA - Sustainable Integrated Multi-sector PLAnning' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

SIMPLA responds to topic EE 7 ‘Enhancing the capacity of public authorities to plan and implement sustainable energy policies and measures’ and its ultimate goal is empowering public authorities to develop, implement and finance sustainable energy policies and actions by creating the conditions for a smart integration between SEAPs (Sustainable Energy Action Plans) and SUMPs (Sustainable Urban Mobility Plans) - or similar plans - in cities, towns and their aggregations with a population between 50.000 and 350.000 inhabitants. SIMPLA’s work-plan focuses on the establishment of a network of National Focal Points (NFPs) in 6 countries (expanding to further 12 through replication actions) merging technical expertise, methodological know-how and institutional capacity of technical partners and public authorities. The NFPs realize an ambitious, innovative work-plan, encompassing  capacity building and coaching (on-site and via the web), enhancement of multi-level governance looking for synergies and economies of scale, extensive involvement of public authorities and stakeholders, promotion of mutual learning and best practices.EU added value (involving countries and areas with different levels of tradition in integrated mutli-sector planning) and capitalization of previous EU-funded initiatives are among the project's guiding principles.SIMPLA thus contributes to the EU’s energy and climate targets for 2020 and beyond, reducing GHG emissions, increasing the share from RES and improving energy efficiency, focusing upon sectors with high energy-saving potential (primarily  buildings, renewables for electricity production, urban freight transport and passengers’ mobility).The intensive exploitation of existing networks to promote and support the implementation of project activit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SOCIALLY NECESSARY RAILWAYS', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The SONERAIL project examines the role of socially necessary railways, i.e. those railways, which under EC regulations 1191/69 and 1893/91 cannot be provided on a commercial basis and may therefore be financially supported by a Member State. The overall workplan consists of four main tasks as follows:Task 1: Establish the current situation with respect to definitions used and evaluation criteria applied along with the development of an evaluation methodology for socially necessary railways which can be applied in other passenger services. This will form the basis for the next stagesTask 2: Apply the developed evaluation methodology on specific passenger services with the aim to test this methodology and utilise it to provide information about the performance of the selected passenger services.Task 3: Identify and assess future European operations scenarios which will contribute to narrowing gaps between supplied and demanded service level for different dimensions of service level (incl. a range of policy options regarding socially necessary railways and other passenger modes)Task 4: Provide conclusions and recommendations on best practice operations of socially necessary railways in terms of optimal operations scenarios for reducing the gap between supplied and demanded service level for different dimensions of service.Links with other projects, tasks, areas, programmes, policy actions:SONERAIL takes into account the existence of the other on going project called PRORATA (Profitability of rail transport and adaptability of railways)Concertation between SONERAIL and PRORATA will be made in order to ensure that the methodologies are consistent. Although, there will be some differences in the methodology because of the social aspects in SONERAIL and the commercial aspects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'MEFISTO - Meniscal functionalised scaffold to prevent knee Osteoarthritis onset after meniscectomy'.

assistant: **Innovation**

MEFISTO will develop two novel solutions to treat meniscus loss as a strategy for preventing the onset of an epidemic of post-meniscectomy knee osteoarthritis (OA) in Europe. Morphological profiling will identify the population of patients who, after meniscal resection, are at higher risk of early compartment degeneration, providing a personalized approach for the patient. The two different reconstructive strategies are: i) a controlled vascularized bioactive biodegradable meniscal scaffold, which will regenerate the native meniscus. This strategy will address younger patients with early osteoarthritic changes. ii) a bioactive non-biodegradable meniscal prosthesis, which will act as a mechanical unloading device and a drug delivery system, with the capacity to modulate the inflammatory environment. This strategy will address patients with advanced OA. A socio-economic analysis of the efficacy of existing meniscal substitutes will complete the project. This analysis is of vital importance for the European healthcare system, as it will provide a clear understanding of the costs and benefits of current clinical practice and predict the impact of the two new interventions. The technological innovation lies in the development of biologically active functionalized nanobiomaterials that can interact with the surrounding articular tissues. The biodegradable scaffold will promote revascularization in the peripheral zone, while leaving the inner zone avascular, reflecting the native meniscal tissue and functionalization with drug delivery micro/nanoparticles of the non-biodegradable device will provide modulation of inflammation. The impact is expected to be significant as so many patients have undergone or will undergo meniscectomy. The interventions developed in MEFISTO will pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'GALVANI Scalable Workflow Innovation for Focal tES Therapy' (2021-2027).

assistant: **Concept**

The ERC Galvani project aims to revolutionize transcranial electrical brain stimulation (tES) therapy for epilepsy through acomputational breakthrough. By combining the expertise of clinical researchers and computational neuroscientists, the project willdevelop personalized brain stimulation solutions integrating magnetic resonance imaging (MRI) and stereoelectroencephalography(SEEG) data into advanced brain models. Neuroelectrics, a leader in medical neurotechnology, is implementing these solutions in apipeline that transforms patient data into individualized brain models and optimized tES protocols in focal epilepsy. However,algorithms are highly dependent on the availability of high-quality MRI data and require time-consuming manual processing. Clinicaltranslation at scale faces two key challenges: first, image head cropping and uneven data quality in MRI scans, and second, brainlesions, which deviate from normal anatomy and require manual segmentation by trained operators. These result in a more complex,time-consuming, and costly personalization process. To overcome these obstacles on the path from ground-breaking research toinnovation, the SWIFT project introduces an AI-based deep learning approach that enhances MRI data quality and automates thehandling of anatomical alterations, such as brain lesions, improving model accuracy and reducing processing time. To ensuretranslation into innovation, the project will develop a business strategy that addresses productization, regulatory, intellectualproperty, and commercialization challenges toward the goal of making model-driven tES therapy more scalable, cost-effective, andaccessible to a broader range of epilepsy patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Anticipatory Networking Techniques in 5G and Beyond' (ACT5G).

assistant: **Innovation**

The rapid growth in mobile network data traffic contributed to the unprecedented speed of 4G LTE adoption, creating the need of sustainable capacity growth in next generation of wireless systems, namely 5G. A key success factor of 5G is network and management system design for flexibility by prediction and adaptation. To this end, anticipation is a promising new approach. By predicting and adapting to upcoming events at various time scales, an anticipatory network improving the operation quality and efficiency. First, network resources ranging from spectrum and buffers can be managed optimally to meet users’ requirements. Second, network operators can jointly plan how to share infrastructures and resources to meet their demands at lower costs and better energy efficiency. The ACT5G project addresses these challenges by two parallel research thrusts which we identify as Network Prediction and Reaction Mechanisms. The research in these thrusts ranges from analytic methods and models for anticipatory networks, to optimization in resource management and infrastructure sharing.To achieve the objectives, ACT5G engages in a four-year research program centered around four industrial PhDs. Half of the duration of the involvement of the early stage researchers (ESRs) in the program will be spent at the site of Alcatel Lucent Bell-Labs, giving the core industrial aspect of the ACT5G project.ACT5G brings together a consortium of complementary research skills, ensuring that the involved ESRs conduct top-level beyond-state-of-the-art research, while enjoying a well-structured program for industrial-oriented doctoral studies. The added value of ACT5G is the creation of a critical mass of trained researchers, working together under joint industrial/academic supervision. The outcomes of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The impact of foreign direct investment on local regional economies' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The main task of the project is to examine how the location of Foreign Direct Investment (FDI) can affect local economies within countries using extensive firm level panel data for Belgium, Ireland, Spain, and Portugal. In order to enable comparability across these countries and data sets appropriate regional taxonomies will be identified and relevant agglomeration measures defined. At the aggregate and sectoral level trends in the dispersion of FDI and domestic activity will be documented and compared across countries. At the micro-level the key aspect of interest will be how the degree of FDI within regions has affected such factors as indigenous firm start-up, survival, employment growth and productivity, while appropriately controlling for other important factors. The econometric specification will be embedded in and draw upon existing theoretical economic geography and other frameworks. The results will also have implications for economic policy by providing an empirical platform that will give policy makers more information concerning what role FDI can play in encouraging local regional development. Universite catholique de Louvain's CORE has very strong research skills in the areas of regional economics and econometrics. Current members and affiliated members have been and are frontrunners in the new economic geography literature. The principal benefit for the applicant comes from being exposed to this excellent research environment and the collaboration with and advice and evaluation from acknowledged experts in the field. This will help ensure that the research will be of the highest international caliber. Moreover, several researchers within CORE have access to datasets that are key components to the proposed project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Innovative 5-part haematology analyser for near-patient diagnostics'.

assistant: **Concept**

The INNOHEM project will develop and validate the first Complete Blood cell Count (CBC) haematology analyser including 5-part differential and reticulocytes (5-part analyser) for the decentralized, low-volume testing haematology market. Today, CBC tests are performed using either 3-part or 5-part analysers. The latter are growing in importance worldwide as they are able to provide much more detailed information about the medical condition of the patient. However, 5-part analysers are currently designed entirely for the high-volume testing market with complex, centralized laboratories equipped with large sample automation devices. Recognising market niche and a strong business opportunity, Boule will create a revolutionary point-of-care analyser that will provide reliable 5-part haematology results from a finger-stick blood sample. The new system will disrupt the existing marketplace by redefining the segment for the commercial application of 5-part analysers (from high-volume centralized testing to low-volume near-patient testing). The key need of physicians is the access to an easy-to-deploy analyser for 5-part CBC testing. The analyser should be designed for easy operation in smaller laboratory settings. The users’ needs will be met by creating a user-friendly diagnostic device that allows for low-volume, decentralized and near-patient testing. The Phase 1 project will develop a strategic business plan for the commercialisation of the new product. The Phase 2 project will validate the new diagnostic device. The EU added value will be generated by allowing physicians to make a rapid health assessment of the patient locally and take improved decisions concerning further diagnostic measures or immediate treatment strategy. This will ultimately lead to more personalized a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Dopaminergic Receptors in the brain : Interactions with Adenosine Receptors'.

assistant: **Innovation**

To examine the mechanisms underlying the adenosine A2a/dopamine D2 and the adenosine A1/dopamine D1 receptor interactions at the cellular level, using fibroblast cell lines cotransfected with different combinations of cDNAs of adenosine A1 and A2a receptors and dopamine D1 and D2 receptors, as well as striatal cell cultures.To characterize the changes in striatal A2a/D2 and A1/D1 receptor interactions occurring in a rat model of Parkinson' s disease, to evaluate the possible role of adenosine antagonists as a therapeutic strategy for Parkinson' s disease. A large number of studies have demonstrated that adenosine can interact with dopaminergic neurotransmission in the basal ganglia. The working hypothesis of the present project states that the interplay between adenosine and dopamine in the basal ganglia is mediated through specific interactions between adenosine and dopamine receptor subtypes, mainly between adenosine A2a and dopamine D2 receptors and between adenosine A1 and dopamine D1 receptors.  The first objective is to determine the basic mechanisms of the A2a/D2 and the A1/D1 receptor interactions at the cellular level using fibroblast cell lines stably cotransfected with different combinations of A2a, A1, D2 and D1 human receptor cDNAs and primary striatal cultures. These receptor interactions will be studied at the receptor level (radioligand binding experiments), second messenger level (adenylate cyclase activation experiments) and functional level (intracellular calcium influx experiments). A2a/D2 and A1/D1 receptor interactions will also be studied in human basal ganglia by using quantitative receptor autoradiography.  The second objective is to characterize the changes in striatal A2a/D2 and A1/D1 receptor interactions taking place in an animal model of Pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Quantifying and upscaling nitrogen fixation in pristine ecosystems: Uncovering the climatic, ecological, and molecular control mechanisms', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Plant productivity in pristine ecosystems like boreal and tropical cloud forests is limited by soil nutrients, primarily nitrogen (N). Mosses are major contributors to ecosystem productivity in these habitats, and most of them are colonized by N2-fixing cyanobacteria, thereby providing N to the ecosystem. Despite this key role, critical knowledge gaps exist. In particular, the climatic controls of moss-associated N2 fixation remain unclear, limiting our ability to quantify and project climate change effects on this fundamental ecosystem function. Further, it is unknown whether mosses and associated cyanobacteria share a mutualistic (both partners benefit) or parasitic (one partner benefits at the expense of the other) relationship. Yet, the balance of this association is crucial for maintaining ecosystem productivity. I will combine field, laboratory and modelling approaches to fill these knowledge gaps by addressing 4 objectives. I will (1) identify the climatic controls of N2 fixation in mosses from contrasting ecosystems: boreal forests and tropical cloud forests, (2) ascertain the degree of mutualism or parasitism between moss and cyanobacteria using transcriptomics, (3) determine nutrient exchange rates between moss and cyanobacteria using nanoSIMS. The ultimate goal is (4) to model ecosystem N input via N2 fixation in boreal and tropical ecosystems.  In SYMBIONIX, I will uniquely combine biogeochemistry with ecology across scales, offering a break-through in ecosystem research. Application of cutting-edge methods will enable progress previously unachievable in ecosystem ecology. I will interlink a vital ecosystem function to its molecular and ecological foundation. A synthesis will be achieved via the parameterization and validation of global circulation models, r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Extension, enhancement and strengthening of established collaborations to create a knowledgebase for biomarker based research on aging' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

BIOAGE is collaboration between five distinguished universities and research institutes in Europe, New Zealand and Australia. The overall aim of the proposed staff exchange programme is to build, extend and strengthen sustainable collaborations between the partners so as to create a knowledge base for biomarker based research with focus on ageing.Within this aim the exchange objective is to provide researchers with: 1] an international platform to learn, train and apply novel biomarker as well as sampling techniques and methods, 2] discuss the opportunity to formulate new joint collaborative research and funding proposals and 3] the possibility to participate in large Human Biomonitoring studies and 4] international exposure and intercultural understanding.The exchange programme consists of visits ranging from 1-8 months for PhD students, postdoctoral and early career scientists and experienced researchers to enable research collaboration, access to an extended infrastructure base and the development of biomarker expertise at partner institutions.The expertise and facilities of the partners are highly complementary and the synergy lies in the combination of expertise on biomarker quality and validation, sampling techniques, clinical trials with elderly, nutrition and physical activity interventions as well in the experience of performing large international biomonitoring studies.The work plan consists of four work packages, one around management, one on biomarker validation and quality, one around invasive and non-invasive sample techniques specifically in clinical trials with elderly and one around the knowledge of planning, participating and data analysing of large human biomonitoring studies.BIOAGE contributes to the EC priorities since it uses mobility to transfer k