RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Network on epizootic disease diagnosis and control' (EPIZONE) under Sixth Framework.

assistant: **Objectives**

Epizootic diseases in agriculture and aquaculture animals constitute major risks for the food production. Such diseases spread very fast in high densities of susceptible animals through animals, vectors or animal products. Outbreaks in Europe showed enormo us social and economic impact, and need to be addressed across the whole production chain of animal-related food. The objective of EPIZONE is to improve research on preparedness, prevention, detection, and control of epizootics by improvement of excellence through collaboration. EPIZONE will be developed for integration of scientists in health and production of animals, at the European Level. Benefits of EPIZONE primarily concern consumers and stakeholders throughout the food supply chain but also the agric ulture administrations and biotechnology companies. EPIZONE includes 14 institutes from 11 countries. Partners maintain networks worldwide, therewith linked to EPIZONE, and most have (inter)national ref-lab based tasks for control of epizootics. The manage ment structure of EPIZONE will generate durable interactions between partners. Initially +300 key scientists with international reputations, complementary expertises and skills are identified within the partners. EPIZONE will generate a worldwide network o f institutes contributing to available expertise and spreading of excellence. EPIZONE includes an SME specialised in dissemination of knowledge via Internet. Organisational work packages will develop integration activities, including communications, meetin gs, and training/continuous professional development. Scientific work packages will undertake jointly executed research on epizootics selected on importance in Europe and cover 4 thematic areas: Diagnostics, Intervention Strategies, Surveillance and Epidem io
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Robots for protecting crops' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The most important challenge in European agriculture is the cost and scarcity of labour. Robots have replaced labour in several sectors of the economy. Agricultural robots have not yet reached widespread acceptance. The vision of ROBS4CROPS is an agricultural sector where robots will replace humans in all heavy and unpleasant work! From a technical point of view, agricultural robots do not reach their potential because they are used as stand-alone units rather than as part of a complete, innovative robotic system. From a non-technical point of view, agricultural robots do not fit well with current farming practices and agricultural standards and are not supported by an ecosystem of stakeholders.ROBS4CROPS will tackle technical challenges by creating a robotic farming solution that consists of three elements: smart implements, autonomous vehicles, and the farming controller. Existing agricultural implements and tractors will be upgraded so that they can function, together with existing agricultural robots, as parts of a robotic system. Development and testing will take place in real farming environments (real operating conditions), in four countries, in iterative cycles, and in close collaboration with stakeholders. ROBS4CROPS will tackle non-technical challenges by using existing agricultural standards, by utilizing existing machinery (thus lowering the initial investment needed), and by addressing the lack of maintenance, insurance, financing and training. Compliance with regulations, robo-ethics and socio-economic impact will be explicitly addressed. Robotics offers an opportunity to develop novel business models. Building the ecosystem for agricultural robotics will take place iteratively, in parallel with technical development. The complete robotic system (technical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Brain Mosaicism Matters: Organoids in focus to unveil mechanisms in epileptogenic cortical malformations'.

assistant: **Concept**

Epilepsy, a global neurological disorder affecting around 70 million people, poses a significant medical challenge, with one-third of patients facing drug-resistant epilepsy. Cortical malformations such as focal cortical dysplasia type II (FCDII) are associated with pediatric drug-resistant epilepsy for which surgical intervention serves as the main therapeutic approach for seizure control. FCDII is marked by cortical dyslamination and the presence of abnormal cytomegalic cells. Recent findings show that FCDII results from brain mosaicism due to postzygotic mutations in genes of the mTOR pathway, which produces excessive activation of the pathway. Nevertheless, as the human surgical FCDII samples represent an advanced disease stage, we poorly understand its developmental origin and mechanisms. Moreover, the link between mTOR activation and epileptogenesis remains unclear.To address these critical knowledge gaps, a disease-relevant FCDII model is needed. For the preservation of human-specific features, I will use a mosaic cortical organoid model that expresses an inducible MTOR-S2215F mutant construct to reflect the somatic nature of FCDII. Induction of the mutation at different time points will shed light on the specific time frame during which mutations occur in FCDII patients and enable us to generate a preclinical model replicating an FCDII-like phenotype. Next, I will perform single-cell transcriptomic profiling at various developmental stages to uncover the cellular and molecular mechanisms behind FCDII development. Finally, the neuronal network activity of mosaic FCDII cortical organoids will be characterized, focusing on identifying the primary drivers of epileptiform activity among mutant cytomegalic or non-mutant nearby cells. In brief, this preclinical FCDII m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Orsay training site on emergent phenomena in condensed matter physics: from the macro- to the nanoscales' (2002-2006).

assistant: **Innovation**

The Orsay Training Site on Emergent Phenomena in Condensed Matter Physics" offers the possibility to early stage researchers to apply for Ph. D. or shorter periods at the Laboratoire dePhysique des Solides d'Orsay. This laboratory is the largest institute devoted to condensed matter physics in France. It has, over nearly 45 years, formed most of the French community of condensed matter physics, as well as many foreign students and visitors. It has pioneered, since the 60's, important advancements in the field of condensed matter physics. Its scientific tradition enables numerous high level international collaborations and an outstanding experience in high quality research training. Students here benefit from the unique environment of the Orsay-Saclay area, where many French public or corporate research laboratories are located.The project purpose is to develop the research-training offer and stimulate the education and mobility of early stage researchers, in new and important fields of Condensed Matter Physics. The aim is to take advantage of this environment for training "European Scientists in Condensed Matter", able to pursue a European or international career in academic or corporate research. Our objective is to set the highest standards for early stage training, so as to become a European centre of excellence in these issues.The research project will be devoted to emergent physical phenomena in Condensed Matter Physics, which appear as important both on fundamental research aspects and for technological applications. A particular emphasis will be put on the new states of matter in correlated electron systems, the new physical phenomena at the nanometre scale and novel studies of soft and biological matter at the nanoscale. These fields encompass an extraordinarily
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel tailored ceramic membranes for water treatment applications' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This project addresses an acute and relevant worldwide problem: The scarcity of fresh water. The current solutions to this problem are based on desalination of sea water and on wastewater treatment. In both cases, the state-of-the-art uses reverse-osmosis membrane technology, that employs polymer membranes. The problem is that these membranes are sensitive to fouling and degradation, and although they are relatively inexpensive their frequent replacement is costly and labor-intensive. Here we propose using a new type of hybrid ceramic membranes, developed in our group, as pre-treatment filters (ultrafiltration) in the purification process. Ultimately, we also envisage a one-stage reverse osmosis water purification process using only the hybrid ceramic membranes. These novel membranes are extremely stable, and are easily tailored to specific applications. The project will boost the career of the applicant, Dr. Vitaly Gitis. He will be trained in the synthesis of these new hybrid materials, enabling him to transfer the knowledge to his home university and apply it in his research group. Combined with his considerable experience of water purification processes, the new knowledge will give him a ‘research edge’ that will make him a leader in the field. Moreover, the additional ‘soft skills’ training that he will receive, plus the international and interdisciplinary experience, will cement his position in his home country. Finally, the host institution will also benefit substantially from the project, as the applicant will transfer his own knowledge and experience to the hosting group and to the institute.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'IL-2 gene therapy for chronic hepatitis B virus infection' under Horizon 2020.

assistant: **Concept**

Hepatitis B virus (HBV) infections remain a major public health issue worldwide. Over 350 -400 million people are chronically infected by HBV, and about 1 million people die each year from the complications of this infection (cirrhosis and hepatocellular carcinoma) with a consequent hefty economic impact on national health systems. This led the World Health Organization to recognise HBV infection as a key priority and adopt  the global health sector strategy to eliminate viral hepatitis, with a target of reducing new infections by 90% and mortality by 65% by 2030.The risk of developing a chronic infection in healthy adults is due to a weaker, dysfunctional and narrowly focused CD8+ T cell response. Since the mechanisms underlying HBV persistence are not fully elucidated, current treatments (antiviral drugs and Interferon) aim to reduce the development of liver disease, while a definitive treatment for curing this infection is not yet available on the market.Within the ERC Consolidator Grant 725038 “FATE”, we recently characterized the mechanisms behind the ineffective CD8+ T cell response towards HBV, demonstrating the potential efficacy of interleukin-2 (IL-2) – a cytokine – to reactivate it, thus achieving antiviral activity. This discovery, jointly with our proprietary third-generation, self-inactivating lentiviral vectors (LVs) that allow selective hepatocellular expression of IL-2, pave the way to single-dose gene therapy-based approach, a potential functional cure against chronic hepatitis B. 2LIVEr project intends to optimize and further validate our novel therapeutic approach from both a technical and commercial standpoint, moving from TRL3 to TRL4, thus fastening the roadmap towards the market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'To investigate the properties and migration of volatile organic compounds (voc) in floor systems with emission barriers and recommend suitable methods for reducing their emission into room air.' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

PMVOC will investigate the properties of Volatile Organic Compounds (VOC) and their migratory paths in floor constructions in buildings and the possible benefits of introducing an emission barrier. VOC are the result of the interaction of floor coverings, moisture and concrete. They are suspected as a major contributor to sick building syndrome (SBS) and as such a cause of health damage to humans. The aim of PMVOC will be to recommend better methods and products for controlling the emission of VOC into room air.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Conversion of Sugar Cane Biomass into Ethanol' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The project aims at developing the first cost-effective and industrially viable process for converting sugar cane bagasse and trash (i.e. sugar cane biomass) into fermentable sugars. Furthermore, the aim is to integrate such a process with existing production of 1st Generation ethanol based on sugar cane.  In order to develop such a process, a deeper knowledge about the structural components of sugar cane biomass will be investigated with the aim of capturing the easier fraction of the cellulose sugars. Furthermore, the project will focus on developing a detailed understanding of the dynamic impact between pretreatment and enzymatic hydrolysis in order to specifically design the process and enzymes for cost-effective cellulose conversion.   The consortium, which builds on an already established partnership, involves leading industry and Academic partners within the relevant fields from Europe and Latin America.  The main technical barriers in the project relate to the application of an integrated approach, achieving economically attractive production of 2nd generation ethanol based on sugar cane biomass as opposed to converting biomass into energy or other alternative use. Moreover, challenges are related to achieving process compatibility with existing plants and the accomplishment of a simple and cheap process.  The proposed project will focus on the following RTD activities: - Detailed characterization of structural components in sugar cane bagasse and trash - Understanding the treatability of various fractions  - Pretreatment of biomass with focus on integration with existing technology - Enzyme development for improved cellulose hydrolysis - Process simulation and cost estimation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'High-throughput discovery of degrons encoded by posttranslational modifications'.

assistant: **Concept**

The proteins of a cell are constantly turned over to adapt to changing environments or to eliminate damaged protein species. 80% of protein degradation is mediated via the ubiquitin-proteasome system (UPS). Specificity of the UPS is conveyed by E3 ubiquitin ligases (E3s), which transfer ubiquitin chains onto substrates to mark them for proteasomal degradation. E3s recognize their substrates via motifs termed degrons. Identifying degrons of all E3s would boost our understanding of proteostasis and would help designing pharmacologic strategies to modulate E3 activity. However, the “degron logic” of most of the >600 E3s encoded in the human genome remains elusive. This gap in our understanding of E3-degron relationships is related to the fact that degrons can be encoded by chemical modifications/posttranslational modifications (PTMs), which are not amenable to previously developed high-throughput degron discovery approaches via functional genomics. Here, we propose the Degron Miner platform as a high-throughput approach to systematically investigate the impact of PTMs on target protein stability. To this end, we will generate a 9000-member DegTag library consisting of modified peptides linked to a ligand that binds a nano-luciferase-tagged target protein. This library can be screened in a high-throughput fashion in live cells to select DegTags that efficiently degrade the target protein. To unravel the underlying mechanism and match E3s to the identified PTM-degron, I will employ FACS-based CRISPR/Cas9-KO screens and proteomics-based interactomics approaches. Further, I will leverage the identified PTM-degrons in chemical biology and FACS-based CRISPR/Cas9-KO screens to identify the endogenous substrates of E3s and the mechanisms leading to PTM deposition.Ultimately, the D
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Role of the vasculature in neuronal migration. 'The neurovascular link'' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

A fascinating characteristic of the anatomy of the vascular system is that blood vessels exhibit a high similarity in their branching pattern and often a remarkable alignment to nerve fibers. This parallel wiring of the vascular and the nervous system might reflect its mutual dependence and also might indicate mutual guidance phenomena, with vessels providing the signals and the scaffold for growing nerves and nerves secreting angiogenic cues to guide developing vessels.The main goal of this project is to elucidate the molecular mechanisms by which blood vessels may lead the neurons to achieve proper positioning at the developing brain and the molecular cues that are involved in this guidance process. More precisely, we will explore the role of the vasculature on neuronal migration via the Reelin pathway. Reelin is a large, secreted glycoprotein that acts as a guidance molecule on migrating neurons to regulate their proper positioning during brain development. Reelin binds to two lipoprotein receptors, VLDLR and ApoER2, and induces the phosphorylation of the adaptor protein Dab1. Mice that lack Reelin expression (Reeler mice) exhibit severe neuropathological abnormalities. Our preliminary data identifies Reelin as an angiogenic factor and is the basis for an exciting project that aims at studying Reelin as a putative angioneurin, a novel concept of molecules that affects both neural and vascular cell processes. To explore this we will design an endothelial specific Dab1 null mice (Tie2Dab1-/-) to study the loss of function of Reelin selectively on endothelial cells and we will study the contribution of the vasculature to the nervous system defects in the reeler phenotype. This project will contribute to elucidate the molecular basis of the neurovascular link in health a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Conductive Metal-Organic Framework films: synthesis and in situ environmental Scanning Probe Microscopy for enhanced chemical sensing'.

assistant: **Objectives**

Electrically conductive Metal-organic frameworks (cMOFs) are a recently developed class of materials that display electrical conductivity and a well-defined porous structure, formed by the coordination of metal nodes and organic ligands. These unique properties make them attractive for applications in electrocatalysis, energy storage and sensing. This emerging field still faces important challenges, such as the lack of general fabrication methods that provide high-quality cMOF lms (scalable, control over thickness, roughness, crystallinity), and the difficulty in accurately characterizing charge transport and sensing mechanisms, with unknown interplay of various structural and morphological factors (crystallinity, orientation, grain boundaries and defect sites). To tackle this, the main objective of this project is to design and synthesize cMOF films, and integrate them into field effect transistors (cMOF-FET), an emerging platform for chemical sensing. The project aims at i) developing fabrication methods that enable high quality cMOF films, and ii) improving the understanding of the local electrical properties of the cMOF films using advanced environmental Scanning Probe Microscopy (SPM) techniques, determining their influence in cMOF-FET performance. The use of SPM in operando cMOF-FET devices will enable the correlation of microscopic structural and electrical features with macroscopic transport properties, offering real-time insights into charge dynamics and the influence of various vapors. The results will allow to engineer a proof-of-concept cMOF-FET sensor for air pollutants. This action is expected to have significant scientific impact by disclosing unknown mechanisms and providing routes for optimization of cMOFs, as well as societal and economic impact due to