RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The value of diagnostics to combat antimicrobial resistance by optimising antibiotic use' (VALUE-Dx) under Horizon 2020.

assistant: **Objectives**

Antimicrobial resistance (AMR) is of great public health concern, causing numerous losses of lives worldwide and threatening to reverse many of the considerable strides modern medicine has made over the last century. There is a need to stratify antibiotic and alternative treatments in terms of the actual benefit for the patient, improving patient outcome and limit the impact on AMR. High quality, effective and appropriate diagnostic tests to steer appropriate use of antibiotics are available. However, implementation of these tests into daily healthcare practice is hampered due to lack of insight in the medical, technological and health economical value and limited knowledge about psychosocial, ethical, regulatory and organisational barriers to their implementation into clinical practice.VALUE-Dx will define and understand these value indicators and barriers to adoption of diagnostics of Community-Acquired Acute Respiratory Tract Infections (CA-ARTI) in order to develop and improve health economic models to generate insight in the whole value of diagnostics and develop policy and regulatory recommendations. In addition, efficient clinical algorithms and user requirement specifications of tests will be developed fuelling the medical and technological value of CA-ARTI diagnostics. The value of diagnostics will be tested and demonstrated in a unique pan-European clinical and laboratory research infrastructure allowing for innovative adaptive trial designs to evaluate novel CA-ARTI diagnostics. Close and continuous interaction with the VALUE-Dx multi-stakeholder platform provides for optimal alignment of VALUE-Dx activities with stakeholder opinions, expert knowledge and interests. A variety of dissemination and advocacy measures will promote wide-spread adoption of clinical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Design, production and certification of synthetic polymer referencematerial for multi-element analysis' (PERM), addressing dissemination and exploitation.

assistant: **Impact**

Currently, and in support of the industrial development phase, production control and quality management, the European polymer industry needs to determine more than 60 elements in polymer material, in concentrations ranging from percent down to the ng/kg level. For the European polymer industry alone, this consitutes an estimated annual cost of about 50 MECU. These analyses reflect the determination of additives, catalytic residues and contaminants in a polymer material. To improve the accuracy and precision of the currently used analytical measurement protocols, certified reference materials (CRMs) are an ideal tool. However, CRMs of this type are lacking. Furthermore, from an environmental point of view, the lack of suitable CRMs for heavy element determination impedes the effective implementation of the EC Directive 94/62 concerning plastics packaging and packaging material. This directive regulates the amount of heavy metals (Cd, Cr, Hg and Pb) in plastics and was issued in December 1994.The objective of the project is the production and certification of a set of CRMs to be used for element analysis, more specifically the production and certification of one set of two consumable synthetic polymer reference materials consisting of a polyolefinic base material doped with Cd, Cr, Hg and Pb at two levels of concentrations, namely ca. 100 mg/kg for each element (except Hg at ca. 10 mg/kg) and ca. 10 mg/kg for each element (except Hg at ca. 1 mg/kg). Furthermore, the material will be doped with an certified for As, S, Cl and Br. In addition, an intercomparison of analytical methods used for the determination of the above elements in polymer material will be organised among European laboratories; European polymer manufacturers will participate in this project.The primary m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The evolutionary ecology of bacterial immune mechanisms' (EVOIMMECH) targeting Horizon 2020.

assistant: **Abstract**

Bacteria have a range of immune mechanisms, but it is unclear why this diverse armamentarium evolved. The most important immune mechanisms are (1) Surface Modification (SM) (2) Abortive infection (Abi) (3) Restriction Modification (R-M) (4) CRISPR-Cas and (5) prokaryotic Argonaute (pAgo), all of which can occur as stand-alone mechanisms or in combination. The individual mechanisms differ in key aspects, such as their fitness costs (constitutive versus inducible), specificity (indiscriminate versus specific), the recipient of the benefits (individual versus group), the speed of de novo resistance evolution (rapid versus slow), and heritability of immunity. Here I will take a combined in vitro and in vivo approach to tease apart the variables that drive the evolution of these diverse stand-alone and integrated bacterial immune strategies in nature, and examine their associated co-evolutionary dynamics. I focus on three ecological variables that are consistently important in host-symbiont co-evolution: (1) force of infection (2) spatial structure (3) presence of mutualists (plasmids). First, I will perform in vitro manipulations using Pseudomonas aeruginosa PA14 variants that carry either single or multiple immune mechanisms. Next, I will sequence metagenomes, transcriptomes and viromes of microbial communities from environments that differ in ecological variables that are important in vitro, to examine their importance in vivo. Key ecological mechanisms identified in the first two parts of the project will be used to guide mesocosm experiments to experimentally confirm that these mechanisms are the drivers of the observed patterns of resistance and co-evolution in nature. Finally, I will share my data with mathematical biologists to generate theoretical models to predict
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Enhancing farm productivity and guaranteeing CATTLE traceability and welfare with blockCHAIN' (2014-2020).

assistant: **Innovation**

Analysis of the Direct Payment Scheme and farm incomes by DG-AGRI shows that on average about 50 % of the European livestock farms are reliant on subsidies. Currently, precision farming is only profitable for big farms and the investment is always difficult to pay back. Besides, there is an increasing demand on more information on food quality and safety and traceability. Thus, the EU livestock sector is in need of innovative tools to (i) increase its efficiency and become an attractive activity for the younger generations and (ii) assure full transparency and traceability along the supply chain. In this context, CATTLECHAIN 4.0 project aims to develop an integral smart solution to support the EU livestock sector to overcome the aforementioned challenges. By recording different parameters from the cows with IoT wearables, and analysing this data with Artificial Intelligence algorithms, farmers get a decision support tool about their farm condition, so they can take immediate action if any issue arises and prevent losses/health issues. Besides, by aggregating the data from multiple cows and farms in a blockchain based cloud platform, consumers and public authorities can access a traceability tool with truthful and secure data about the meat/dairy supply chain. Finally, aligned with consumers’ demands and thanks to the information gather by the IoT wearables, an Animal Welfare Seal will be created that guarantees that the meat and dairy products meet the highest animal welfare standards. This ground-breaking technologies and services will be validated in ambitious trial scenarios with 5.000 cows. The project will boost the growth of the two industries involved, firstly of the coordinator SENSO a tech-startup that will exponentially increase its turnover, and secondly of N
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Digital Crossings in Europe: Gender, Diaspora and Belonging' (CONNECTINGEUROPE).

assistant: **Concept**

Many immigrants enter Europe both legally and illegally every year. This creates multiple challenges for the Union, including the gender and ethnic segregation of migrant groups, especially women. While it strives for an inclusive and integrated society as envisioned by the EU motto ‘Unity in Diversity’, it is still often perceived more as ‘Fortress Europe.’ This project focuses on the ‘connected migrant’, studying how virtual communities of migrants, or digital diasporas, convey issues of technology, migration, globalisation, alienation and belonging capturing the lives of migrants in their interaction with multiple worlds and media. More specifically, it will investigate whether digital technologies enhance European integration or foster gender and ethnic segregation, and, if so, how. Using a multi-layered and cutting-edge approach that draws from the humanities, social science and new media studies (i.e. internet studies and mobile media), this research considers: 1. How migration and digital technologies enable digital diasporas (Somali, Turkish, Romanian) and the impact these have on identity, gender and belonging in European urban centres; 2. How these entanglements are connected to and perceived from outside Europe by focusing on transnational ties; and 3. How digital connections create new possibilities for cosmopolitan outlooks, rearticulating Europe’s motto of ‘Unity in Diversity.’ The outcomes of this work will be innovative at three levels. a) Empirically, the project gathers, maps and critically grounds online behaviour by migrant women from a European comparative perspective. b) Methodologically, it breaks new ground by developing new methods of analysis for digital diasporas contributing to the development of ‘postcolonial’ digital humanities. c) Conceptu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New feedstock and innovative transformation process for a more sustainable development and production of lignocellulosic ethanol' (BABETHANOL).

assistant: **Concept**

Today, USA and Brazil have massively invested in ethanol mono-production, taking advantage of their respective native crops, intensive culture practices and large availability of land. These renewable biofuel production models cannot be applied to most of the industrial and emerging countries. For these countries with limited land use, one of the best solutions to comply with their objectives of renewable biofuel and avoid food/fuel competition is the production of ethanol from diversified lignocellulosic residues. Yet, more research efforts are necessary to reach this objective.  The BABETHANOL project proposes solutions for a more sustainable approach of 2nd generation renewable ethanol, based on a “moderate, environmental-friendly and integrated” transformation process that should be applicable to an expanded range of lignocellulosic feedstocks. The new process, called CES - Combined Extrusion-Saccharification, will be an alternative to the costly processes of the current state-of-the-art, notably the pre-treatment requiring much energy, water, chemical products, detoxification and waste water treatment. CES will be developed and tested from laboratory up to semi-industrial pilot scale with different new feedstock: Blue Agave Bagass, Palm Oil Empty Fruit Bunches and Olive oil Milled Husks. A Europe-Latin America lignocellullosic biomass catalogue will also be developed as a further contribution to the expansion of feedstocks.   The success of the new project much relies on the  well-balanced consortium with 7 European partners, 8 Latin American partners, the multidisciplinary expertise with agriculture/agronomy, chemical/catalysis, microbial systems engineering, industrial plant design and the integration of SMEs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Functional Genomics of Familial Hypertrophic Cardiomyopathy' (FUGEN-FHC), addressing dissemination and exploitation.

assistant: **Impact**

Familial hypertrophic cardiomyopathy (FHC) is a myocardial disease with the major feature of asymmetric septal hypertrophy (ASH). It is one of the most common monogenic diseases with a disease prevalence of 1:500 in young adults. It is the major cause of s udden death in the young and is associated with a significant risk of heart failure. The major objective of the present project is the elucidation of the mechanisms by which cardiac myosin-binding protein C (cMyBP-C) mutations lead to FHC. Particularly, we will investigate two new concepts, the first one emerging from our recent data: (1) Impairment by truncated cMyBP-C mutants of the ubiquitin-proteasome system (UPS) as a pathogenic factor of FHC and (2) Specific mobilization and differentiation of recent ly identified Isl-1 positive cardioblasts as a cause of ASH. Other objectives concern the role of cMyBP-C in sarcomere structure and its phosphorylation in regulation of cardiac contraction. The recent development of two targeted cMyBP-C mice by L. Carrier will allow to resolve these issues. The heterozygous cMyBP-C null mice is the first model with ASH and will therefore enable us to identify the cause of this enigmatic alteration. L. Carrier and the Eschenhagen lab recently demonstrated that truncated cMy BP-Cs are substrates and inhibitors of the UPS. Impairment of the UPS in the pathogenesis of FHC is a novel concept in cardiology, which parallels the pathogenesis of some neurodegenerative disorders. The concept will be tested in cMyBP-Cmut/+ mice, which carry a mutation leading to a truncated cMyBP-C. The material and methods developed in the project are at the forefront of progress (targeted transgenesis, recombinant adenovirus, proteasome reporter mice, RNA interference, 3D-engineered heart tissue (inve nted
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Understanding and manipulating the dynamics of chromosome topologies in transcriptional control', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Transcriptional regulation of genes in eukaryotic cells requires a complex and highly regulated interplay of chromatin environment, epigenetic status of target sequences and several different transcription factors. Eukaryotic genomes are tightly packaged within nuclei, yet must be accessible for transcription, replication and repair. A striking correlation exists between chromatin topology and underlying gene activity. According to the textbook view, chromatin loops bring genes into direct contact with distal regulatory elements, such as enhancers. Moreover, we and others have shown that genomes are organized into discretely folded megabase-sized regions, denoted as topologically associated domains (TADs), which seem to correlate well with transcription activity and histone modifications. However, it is unknown whether chromosome folding is a cause or consequence of underlying gene function.To better understand the role of genome organization in transcription regulation, I will address the following questions:(i) How are chromatin configurations altered during transcriptional changes accompanying development?(ii) What are the real-time kinetics and cell-to-cell variabilities of chromatin interactions and TAD architectures?(iii) Can chromatin loops be engineered de novo, and do they influence gene expression?(iv) What genetic elements and trans-acting factors are required to organize TADs?To address these fundamental questions, I will use a combination of novel technologies and approaches, such as Hi-C, CRISPR knock-ins, ANCHOR tagging of DNA loci, high- and super-resolution single-cell imaging, genome-wide screens and optogenetics, in order to both study and engineer chromatin architectures.These studies will give groundbreaking insight into if and how chromatin topolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'European Training Network for the remediation and reprocessing of sulfidic mining waste sites'.

assistant: **Concept**

For more than 100 years the EU mining industries have been discarding their extractive-waste residues. Estimates suggest this represents 29% of the EU-28’s current waste output. When poorly managed these residues are a significant environmental hazard. Sulfidic Cu-Zn, Zn-Pb and Cu-Zn-Pb tailings pose the largest challenge, as they are prone to acid mine drainage. However, these tailings also contain valuable metals. Recently, the EIP Raw Materials launched a “call to arms” to transform the “extractive-waste problem” into a “resource-recovery opportunity”. Additionally, the EIP has warned about the acute shortage of talent in this sector. In order to develop a highly skilled work force, to mitigate environmental risks and to economically recover valuable raw materials, the ETN for the remediation and reprocessing of sulfidic mining waste sites (SULTAN) provides the first-ever training programme dedicated to the reprocessing of tailings. SULTAN has pooled the interdisciplinary and intersectoral expertise of leading EIT RawMaterials members, world-leading mining and chemical companies, covering all links in the tailings-reprocessing value chain. SULTAN develops cutting-edge methodologies to assess the resource potential of Europe’s main tailings families (WP1) and explores eco-friendly mining chemicals for advanced metal-extraction/recovery set-ups (WP2). SULTAN not only recovers the metals but also valorises the clean(ed) tailing residues in circular-economy applications, incl. inorganic polymers, green cements and ceramics (WP3). In WP4 a novel environmental assessment methodology is developed. The 15 SULTAN ESRs benefit from a unique soft-skills training programme (WP5) and maximise the impact of their research through dissemination & exploitation (WP6). This kick-start
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Quantification of long-term exhumation in active mountain belts through detrital fission-track analysis' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The proposed research will use detrital apatite and zircon fission-track analysis of syn-orogenic sediments in order to constrain the temporal and spatial patterns of long-term exhumation in collisional mountain belts. Such data are essential in order to elucidate the tectonic and climatic controls on the topographic development of mountain belts. The four main objectives of this research proposal are:1. To constrain the spatial pattern of long-term exhumation in the Alps and the Himalayas using fission-track analysis of detrital zircon and apatite from samples of foreland basin sediments. Analysis of sediments from modern rivers draining both origins indicate variable exhumation rates along their strike. Our aim is to test whether such differences can be tracked into the geologic past.2. To quantify potential temporal variations in the Cenozoic erosional exhumation of the Alps and Himalayas, which may be related to local and global climate change (e.g initiation of the monsoon system in connection to uplift of the Tibetan Plateau, initiation of glaciation).3. To complete the Alpine data set from previous research with additional samples from the Miocene and Pilocene of the French foreland basin in SE France, in order to improve both its spatial and temporal resolution.4. To further develop and test the detrital fission-track analysis tool by (1) expanding the technique to detrital apatite, and (2) comparing the European Alps and the Himalayas, two active mountain belts that vary an order of magnitude in size as well as in uplift and exhumation rates. The applicant provides his expertise in detrital zircon fission-track analysis, which includes sample preparation (mounting and polishing), etching procedures and dating techniques of zircon samples as well as data analysi