RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Structure of coral-algal overgrowth hierarchies : ecological strategies and anthropogenic impacts' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The project will use the Caribbean coral reef system to develop conceptual understanding of algal-coral habitat interactions. Results will be highly applicable to coral sustaining habitats in the Mediterranean Sea and will provide essential information to improve management of algal overgrown areas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Purification and characterisation of nuclear ptdins -4p-5-kinases - pipkinases - and their role in regulation during the cell cycle' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content The discovery of inositol lipids, and the enzymes required to synthesize them, in the nucleus has led to the demonstration that the nuclear PI-cycle is regulated in a manner distinct from that at the plasma membrane. PtdIns(4P)5-kinase (Pipkinase) synthesizes Ptdlns(4,5)P2, a putative second messenger and a substrate-for three further second messenger molecules. Two distinct isoforms of this enzyme have been found in rat liver nuclei. This project proposes the characterization of both nuclear Pipkinase isoforms with a view to investigating the -regulation of these enzymes during the cell cycle. One isoforms is immunologically related to cytosolic Pipkinase C and monoclonal antibodies are available for immunopurification. The second isoform is immunologically unrelated and will be purified to homogeneity by column chromatography. Production of-monoclonal nuclear-specific antibodies will facilitate the cloning of both isoforms. Using these reagents, regulation of the nuclear Pipkinases will be studied during differentiation and cell cycle progression. Training content (objective, benefit and expected impact) The project provides training in eukaryotic cell biology techniques, lipid biochemistry and cellular signalling processes. With a strong grounding in prokaryotic systems and molecular biology I believe that experience in such a broad range of skills is integral to the development of a scientific career.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An adaptation-based approach to understand resilience after job loss: Identifying the underlying mechanisms leading to adaptive coping and re-employment' (ADAPT) targeting Horizon 2020.

assistant: **Abstract**

Unemployment represents a major societal problem in Europe, strongly related to increasing depression and anxiety rates and high economic costs. In line with European policies on mental health, enhancing resilience against the adverse effects of job loss is a timely priority. In ADAPT, I propose a novel framework and advanced methods to identify the psychological mechanisms (adaptation-based attention and emotion regulation processes) promoting adaptive coping after job loss and facilitating higher possibilities for re-employment. ADAPT is highly original and timely for current societal needs, providing: a) a novel framework beyond traditional approaches in the study of resilience, largely failing to provide successful mental health promotion deliverables; b) fine-grained analyses of adaptation-based mechanisms that can be easily targeted in future assistance protocols; c) integrative analyses of both positive and negative resilience outcomes typically studied in isolation; and d) analyses of dynamics at both short- (immediate daily functioning following layoff) and long-time scales (multi-wave follow-ups across the months following job loss), providing a whole view on the stress-resilience trajectories following unemployment that is lacking in former research. The proposal includes a well-defined program of two-way transfer of knowledge including high-quality training in new advanced techniques for the candidate. ADAPT represents an actual attempt to reach relevant stakeholders in the social assistance and mental health sectors to develop innovative programs of mental health’s promotion. The action will generate knowledge that can be ultimately used to develop interdisciplinary deliverables, including advanced e-tools for early detection of sources of conflict followin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'All Solid-State Super-Twinning Photon Microscope' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The goal of the project is to develop the technology foundation for an advanced optical microscope imaging at a resolution beyond the Rayleigh limit, which is set by the photon wavelength. The proposed microscope technique is based on super-twinning photon states (N-partite entangled states) with the de Broglie wavelength equal to a fraction of the photon wavelength. Such microscopy technique will comprise building blocks for object illumination, capturing of scattered twinning photons and data processing. Based on advanced group-III nitride and III-V alloy epitaxial growths and wafer processing techniques we will build the first solid-state emitter of highly entangled photon states, utilizing the cooperative effect of Dicke superradiance (super-fluorescence) emission. Single-photon avalanche detector arrays with data pre-processing capabilities sufficient for capturing high-order field correlation functions of scattered twinning photons will be developed. A dedicated data processing algorithm for extracting the image of an illuminated object from the statistics of scattered twinning photons will complement the hardware. The project goal is to demonstrate imaging at 42 nm spatial resolution using 5-partite entangled photons at 420 nm wavelength.  This quantum imaging technology will open the way for compact, portable, super-resolution microscope techniques, with no moving parts and no requirements to the optical properties of the sample.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Water resource systems planning' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The complexity of water-related problems in the Mediterraneous countries (with more frequent climate changes than in the rest of Europe) is scalating as the uses of water and the (environmental and others}objectives to be fulfilled continue to expand. Most of the easier structural solutions for greater water resources utilisation have already been implemented and new projects, including interbasin transfers, find some opposition in the society. In these circumstances the need for a rational water resources planning is becoming stronger than ever as a result of the impact of the changes in the general climatic conditions and the increasing demand of the water resources using. The ability to help the decision maker on Water Resource Systems (WARS) planning in practice depends on the sophistication of the tools and techniques available. The WARSYP (WARS Planning) project will remedy the inadequacies of the tools currently available by developing a hydrologic Modelling framework and a Decision Support System to help the planning of large systems currently considered intractable and, so, to narrow the gap between the problem description modelling and the problem policy decision making. The problem consists of WARS planning under uncertainty on climate and hydrological exogeneous inflow and demand for a set of inter-related basin systems along a given planning horizon. The project addresses the improvement of better quality (better utilisation, lower costs) and efficiency (shorter response time) in WARS planning through better hydrologic modelling and decision support system implementations. It will have a direct bearing on the WARS management agencies' assignment of water resources to the requirements of the different uses, by operating significant demand savings and minimis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tracing human cortical neurons involved in epileptic processes at multiple scales' to be submitted under Horizon Europe.

assistant: **Abstract**

Epilepsy is one of the most common chronic neurological diseases in humans, affecting 50 million people worldwide. This brain disorder is characterised by hypersynchronous neural activity resulting in seizures. Abnormal recruitment of cells induces unusual behaviour, sensations or loss of awareness. Epilepsy has a substantial economic effect on health care needs or the loss of productivity in work.Investigating the role of different neuron types in generating pathological activities is essential for identifying what makes a brain region predisposed to generate epileptic events. Most information regarding the properties of neuronal circuits during epileptic activity comes from animal models. However, recent studies have shown substantial differences when comparing human tissue to animals and epilepsy models to disease. I aim to utilise a unique multilevel approach to follow how neurons are recruited into epileptic events and categorise them at an unprecedented level of detail in human epileptic patients. I plan to analyse cellular activity in recordings obtained in vivo and characterise human cortical neurons in vitro with simultaneous intra- and extracellular electrophysiology completed with post hoc histology. This will be the first study examining neuronal behaviour and subtypes in the same epileptic patients, both in vivo (before surgery) and in vitro (after surgery). This innovative approach will provide valuable information on the role of the different neuron types in the generation of epileptiform activity.The fundamental knowledge of the cellular mechanisms of epileptic events specific to humans could help us understand the human disease deeply and thus achieve a significant breakthrough in epilepsy treatment. Enhancement in the diagnostics and cure of epilepsy w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PYHIN-Regulated Memory T cell protection for Infectious Diseases' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Pyrin and HIN domain (PYHIN) proteins play an integral role in the innate immune response to DNA and RNA viruses via direct detection of viral DNA and transcriptional regulation of pro-inflammatory and anti-viral cytokines respectively. Although expressed by various cells of the myeloid lineage, including some classical antigen presenting cells, the role of PYHINs in the context of T cell-mediated adaptive immunity has yet to be investigated. This project aims to elucidate how PYHIN proteins modulate acute and long-term CD8+ memory T cell responses to influenza A virus (IAV), a respiratory RNA virus which causes significant morbidity and mortality annually. Current seasonal IAV vaccines, exhibit variable efficacy and the neutralising antibodies they induce cannot protect against alternative IAV strains, particularly those with pandemic potential. In contrast, IAV-specific CD8+ memory T cells can elicit such cross-protective immunity by targeting conserved viral proteins, thus making the identification of mechanisms which give rise to these cells high priority in the search for a universal IAV vaccine. Herein, we will perform in-depth characterisation of PYHIN expression in human and murine dendritic cells. We will also perform genetic manipulation of PYHIN expression in primary immune cells to interrogate functionality and undertake infection studies in transgenic mice lacking certain PYHIN family members to determine their role in the formation of IAV-specific T cell memory in vivo. Overall, this project is extremely timely, providing crucial mechanistic insight which can inform rational vaccine design aimed at eliciting cross-protective T cell responses to respiratory RNA viruses.


**Keywords:** Viral sensing,  PYHIN,  IFN,  Anti-viral,  Innate,  Adaptive,  T cell me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Environmental indicators for sustainable agriculture in the European Union' (ELISA), addressing dissemination and exploitation.

assistant: **Impact**

The purpose of the ELISA (EnvironmentaL Indicators for Sustainable Agriculture in the European Union) project is to compile, analyse and synthesise existing scientific information on the actual and potential role of indicators for monitoring agricultural land use practices at the European level while giving special attention to sustainable principles and adequate policy implementation. The underlying motive for this project definition is to provide institutions such as European Commission and the European Environment Agency (EEA) with more adequate tools for (1) measuring the impact of agriculture on the environment and (2) monitoring the effects of existing and future agri-environmental measures. In recognition of the complex and interactive mechanisms that characterise environmental processes, international institutions such as EUROSTAT, the EEA and OECD have started recently to apply Driving ForceState-Response Frameworks (DSR). By being strongly based on environmental indicators, the emerging DSR models point at the need to increasingly apply existing as well as new indicators. The aim of this proposal is hence to investigate how current indicators relate to the DSR Framework, which functional links between the different environmental themes require special attention, and which indicators need to be added in order to make DSR Frameworks operational for environmental reporting and policy implementation. The ELISA project is designed to generate the compilation, analysis and synthesis of existing scientific information through the implementation of two major international workshops (project partners and EU institutions) as well as one Internet conference with the participation of a wider scientific audience. The goal is to test an initially drafted initialframework (W
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A New Light on Isocyanide Synthesis', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

SusIsocyanide is an ambitious project that aims for the sustainable synthesis of isocyanides by combining biobased feedstock, visible light and flow chemistry. The aim is to accomplish an economically viable and ecofriendly large scale synthesis of this fundamental and highly versatile building block that has already found widespread appreciation in academia, but suffers from underutilization in the pharma-, fine-chemicals and materials industry. In accordance to the European Green Deal, the devised methodologies will provide an expedient synthetic platform to achieve the automatic synthesis of isocyanides, without the need of toxic and hazardous reagents and avoiding substantial waste production. This will constitute a ground-breaking improvement far beyond the current state-of-the-art, especially considering that the traditionally employed synthetic procedures towards isocyanides have hindered large-scale preparation and therefore industrial utilization. In light of the main goal, SusIsocyanide will constitute a launching platform for the Fellow, since the interconnection between his expertise in photoredox catalysis and flow chemistry and the experience of the host group (Maastricht University) in isocyanide chemistry provides fertile soil for fruitful collaboration and success. Because of the close collaboration in this project with Brightland Chemelot Campus, the Fellow is trained in the industrial utilization of isocyanides in polymer synthesis and advance functional material applications. This highly complements his academic knowledge with industrial application of the developed ideas.Overall, SusIsocyanide will provide a sustainable alternative for the synthesis of isocyanides, taking into account further implementation through industrial applications. The use o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tracking accumulation processes in memory decisions' to be submitted under Seventh Framework.

assistant: **Abstract**

Every day we need to remember whether we have seen people before and adjust our decisions accordingly. The goal of the proposed research is to further our understanding of decisions based on remembered information by following those as they happen in the brain.To be able to study neural decision dynamics, we use computational models of recognition memory that provide explicit mechanisms and hypotheses to be tested in neural data. We are particularly interested in the dynamics underlying the encoding, maintenance and retrieval of to-be-remembered information.  How do the decision and memory networks interact dynamically to ensure good recognition memory performance?  How optimal are our memory decisions? And how do reward and motivation play into our memory decisions? We will study how a memory decision comes into being and how it is influenced by what happened on earlier trials (i.e., adaptations in performance as a result of errors). The results of this project will have important implications for malfunctions of memory-based decision making in e.g., Alzheimer's and schizophrenia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Investigation of the nature of active sites on titania supported molybdenum oxide catalysts for oxidative dehydrogenation of propane to propylene' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Selective oxidative dehydrogenation of readily available alkanes to the corresponding alkenes is an industrially important process. Oxidative dehydrogenation of propane yields propylene which is used in the preparation of polypropylene. The host institute has recently demonstrated that the addition of V205 and Nb205 to titania supported molybdenum oxides, used in the conversion of propane to propylene, leads to an increase in activity of the catalyst when compared with that of the unpromoted material. In addition this increase in activity was achieved without any loss of selectivity. The proposed project aims to identify the factors responsible for the increased activity of this molybdena system using infrared experimental techniques and 51V solid state nuclear magnetic resonance spectroscopy. Other methods for surface studies including scanning and transmission electron microscopy will also be used to examine the reactant/catalyst surface interactions. It is expected that this new data will enable us to characterize the active centres in the oxidative dehydrogenation reaction over the molybdenum oxide catalyst and that in combination with previous results will make the rational design of catalyst material and additives more realisable.