RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'First low-cost semi-passive RFID tags for cold-chain logistics digitalisation and optimisation' in the context of a Horizon 2020 call.

assistant: **Objectives**

Every year, the pharma and food industries lose € 43 billion-worth of medicinal and nutritional products due to failures in cold chain logistics. Cold chain logistics is a complex network, where real-time tracking and monitoring of products is the only way to quickly identify failures and minimise losses. Manufacturers, such as pharma companies, who’s products are lost, are thus leading the push towards optimisation of tracking and tracing practices in cold chain logistics. But how can this be done? Temperature-sensitive sensor technologies, such as stick-on tracker tags, have the potential to reduce waste generated in cold-chain logistics by 5-7%, as temperature problems in the cold chain can be quickly identified and rectified. Today, this instant identification is only possible with so called semi-passive tags, which allow for real-time tracking of temperature-sensitive products. They are however very expensive, costing up to €18/tag. This means that for low-value products, where profit margins cannot cover the cost of these expensive tags, no optimisation of the logistics cold-chain and thus wastage prevention can occur. At Myruns, we have developed the first semi-passive stick-on tag, Tag&Go, at a 96% lower price than existing semi-passive solutions. Tag&Go is made possible through an optimised and patented processing route. Tag&Go simply “drops-in” to customer processes and enables real-time monitoring by any relevant party, such as product manufacturers, logistics providers or customers. Therefore, any failures in the logistics cold-chain can be identified instantly and cheaply, and rectified. €3 billion can be saved by preventing product damage through optimised cold chain logistics practices, and Tag&Go is a key enabler of this saving. Tag&Go has thus already r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Argonaute-associated factors required for translational repression in plant RNA silencing'.

assistant: **Concept**

MicroRNAs (miRNAs) are key post-transcriptional regulators of eukaryotic gene expression. In plants, most miRNAs associate with AGO1 as part of RNA-induced-silencing-complexes  (RISC) to regulate target mRNAs via perfectly or near-perfecly miRNA-complementarity sites. These sites differ from those found in metazoan miRNA target transcripts, where extensive mis-pairing prevents endonucleolytic cleavage, or ‘slicing’, and favors translational repression as an alternative mode of AGO action. Recently, two classes of miRNA action deficient (mad) mutants have been isolated in Arabidopsis thaliana: class I mutants carry lesions in genes required for slicing, whereas class II mutants are still able to slice but yet, fail to silence miRNA target transcripts at the protein level. Studying many examples of endogenous miRNA/target mRNA interactions in the context of class-II mad mutants, the host laboratory showed that most plant miRNAs may, in fact, concurrently slice and translationally inhibit any given pool of target mRNAs, raising the fundamental question of how slicing is avoided during translational repression? One hypothesis holds that translational repressor proteins specifically associate with AtAGO1 on polysomes and block its slicing activity. The recent purification and preliminary characterization, in the host laboratory, of several possible core components of the AtAGO1 RISC support this idea. Combining biochemical and genetic approaches, I will address (i) how these proteins interact with each other, (ii) how their inactivation/over-expression impacts the mode of action of AtAGO1 and its known functions in the various Arabidopsis silencing pathways, and (iii) how these factors may be exploited to uncover the full suite of small RNAs operating preferentially via tran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advancing Nanoscale Devices based on Solid-State Nanochannels (SSNs) modified with (Bio)Active Building Blocks' under Horizon Europe.

assistant: **Concept**

NanoBiosens seeks to expand the potential of Solid-State Nanochannels (SSNs) in the field of electrochemical sensing and the study of phenomena at nanoscale. SSNs have garnered significant attention among researchers due to their promising applications. Inspired by the sophisticated transport mechanisms found in biological channels in nature, SSNs offer precise control over ion transport. Ion transport across SSNs is controlled by the geometry and physicochemical properties of the surface. Thus, highly selective and sensitive transport relies on controlling the internal chemistry and architecture of the channel. SSNs offer, in addition, new avenues to diverse device with nanofluidic and sensing applications. In this project, we endeavor the creation of SSN-based devices for biosensing while simultaneously delving into fundamental studies of building block behavior in nanoconfinement. To achieve these objectives, I will develop and test a novel dual-signal setup that combines electrochemical and iontronic measurements in SSNs. While pure electrochemical sensing faces challenges related to sensitivity, cost efficiency, and complexity, iontronic sensing enables the adjustment of ion transport properties in SSNs enhancing the performance of the sensor. Leveraging SSNs' exceptional sensitivity, we will pioneer highly sensitive enzyme-based biosensors. The innovative dual-signal sensing mechanism will harvest both the information of EC sensing and the high sensitivity of iontronic sensing. It will offer fundamental studies on building block performance within nanoscale confinement, providing invaluable insights into their behavior. Such studies are crucial for refining the precision and effectiveness of nanoscale architectures and their applications. Thus, NanoBiosens extends
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development and immunological evaluation of a vaccine for caninevis ceral leishmaniasis' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

* Purification of a defined parasite antigen, dp72, for use in laboratory vaccine trials against canine leishmaniasis.* Development of molecular biological methods, specifically reverse transcriptase - polymerase chain reaction (RT-PCR), to measure cytokine responses, Interleukin (IL-4, IL-10), Tumor necrosis factor-alpha (TNF-alpha) and Interferon-gamma (IFN-gamma), in vaccinated dogs following infection.* Examination of Th1 and Th2 responses to vaccine antigens in the experimental model for canine leishmaniasis.* Identification of a suitable site in Western Turkey where a vaccine field can be carried out.Expected OutcomeAttempts to develop an IL-4 RT-PCR based on sequence information from other IL-4s have not been successful. We have postponed IL-4 detection for the assessment of Th2 response, and continued with IL-10 RT-PCR for monitoring TH2 response. We have developed a competitive RT-PCR using in vitro internal control (IC) mRNA which is added to the sample in order to be able to quantify the amount of RNA present in the sample.Peripheral blood mononuclear cells (PBMC) from several dogs were tested in this way: one dog was parasitological positive for VL, two dogs were asymptomatic but serologically positive and one dog was parasitologically and clinically negative at time of sampling but became symptomatic over time. PBMCs were incubated either in the absence of antigen or in the presence of Leishmania LV9 antigen or ConA. Ten-fold serial dilutions of IC-RNA were added to the RNA isolates. In general, pPBMCs which have been stimulated with either LV9 antigen or Con1 showed a rise in the production of IFN-gamma; no significant differences could be observed for IM-10 and TNF-alpha mRNA levels.Dogs were vaccinated with Leishmania antigen dp72 plus BCG as an adjuvant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'From Sequence to Consequence - Tools for the Exploitation of Livestock Genomes' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

QUANTOMICS will deliver a step-change in the availability of cutting edge technologies and tools for the economic exploitation of livestock genomes. We will provide the tools to identify rapidly the causative DNA variation underpinning sustainability in livestock and for industry to exploit high-density genomic information. Our adaptable quantitative and genomic tools each based on cutting-edge technologies and valuable in itself, will together form a powerful integrated pipeline with wide application. To deliver these outcomes we will; i) use comparative genomics to annotate putatively functional features of the genomes of the EU’s key farmed animal livestock species; ii) enhance existing molecular genetic tools (to include copy number variation, CNV); iii) deliver computationally optimised tools for genome-wide selection (GWS) to include CNV; iv) apply these tools to important health and welfare traits in commercial populations of dairy cattle and broiler chickens, determining the benefits and constraints; v) use hyper-parallel resequencing of DNA within identified genomic features underlying loci of large effect in significant numbers of animals to catalogue variation; vi) develop new visualisation tools to make this variation publicly available via the Ensembl genome-browser; vii) develop tools to prioritise the likely functionality of identified polymorphisms; viii) validate the utility of the putative causative haplotypes within commercial populations; ix) test the potential advances from combined GWS and gene assisted selection in breeding programmes; x) explore new methods to manage molecular biodiversity; xi) assess the implications of these new tools for breeding programme design, and xii) disseminate results of the project achieving major competitive, animal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Self HealINg soft materials for susTainable prOducts' to be submitted under Horizon Europe.

assistant: **Abstract**

The SHINTO project aims to disrupt the soft robotics market by creating a new market for self-healing structural components, introducing autonomous damage detection and healing in intelligent soft robots. The current field is driven by a high adoption of soft grippers that ensure safe operation for collaborative robots in manufacturing and delicate manipulation in agrifood and warehousing. However, these expensive and mostly non-recyclable soft robots have limited lifetimes due to their vulnerability to damage. In symbiosis, VUB-research groups FYSC and Brubotics have been building soft robots out of self-healing materials that fully recover functional material properties and resulting performances after healing incurred damage. This extends the robots service lifetime and raises their reliability and sustainability, which in combination with their inherent recyclability contributes to economic benefits and the EU Green Deal. In SHINTO, technological breakthroughs will mature beyond lab demonstrators over pilot scale towards commercial viability through synergistic advances in (patented) self-healing polymers, manufacturing, application validation and business development. The team combines profound knowledge of materials and robotics scientists with business experts to establish a new deep tech company, marketing next generation self-healing grippers as semi-finished goods. The beach-head strategy targets existing soft robotics markets based on confirmed product-market fits. Existing feedback loops with key industrial partners, field tests and life cycle assessment allow to cocreate the required quality and TRL for business transition, while limiting business risk to a niche market. Parallel, continuous market analysis enables updating/expanding requirements and extend
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Stable isotope signatures in dorsal fin spines as a non-invasive and non-lethal alternative to otoliths for reconstructing fish life and environmental history' (SIFINS) targeting Horizon 2020.

assistant: **Abstract**

The use of stable isotopes as powerful ""natural tags"" for reconstructing fishes’ environmental and life history, has been largely restricted to ear bones or otoliths. The extraction of otoliths requires sacrificing the fish, which is not allowed for endangered species, and greatly affects the appearance of a fish, which is non-practical for commercially valuable species as it can diminish their market value. The aim of the SIFINS project is to investigate tuna dorsal fin spines as a non-invasive and non-lethal alternative to otoliths for reconstructing environmental and life histories of individual fishes. Using SI signatures in fin spines of key highly migratory temperate and tropical tunas, SIFINS proposes a novel multispecies and interdisciplinary approach integrating the fields of chronology, chemistry and population dynamics research. SIFINS will provide (i) a more refined understanding of the movement and population-stock structure of tunas across their distribution range and (ii) a new and original perspective of stable isotope chemistry research in fishes, particularly relevant to support the management of endangered and commercially valuable species under the EU Biodiversity and Fisheries policies priorities. The results of the project will promote EU excellence in marine fish population dynamics, likely to be of increasing interest in the future due to climate and human-induced change to marine environments. The applicant’s research and professional skills complement the host infrastructure and research team expertise, and their capacity to manage fellowships/grants and train researchers for the successful outcome of all aspects of the project including training, dissemination of results, and outreach activities. SIFINS will contribute to the researcher’s pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Deep Spatial Proteomics: connecting cellular neighbourhoods to functional states' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Health and disease states result from dynamic cellular interactions within spatially defined regions in tissues and organs. In diseases such as cancer, these interactions are often disturbed, but their systematic analysis with respect to their impact on the proteome, a close proxy for cellular function, has so far remained elusive. To overcome this major bottleneck in molecular biosciences, I propose to develop and apply Deep Spatial Proteomics (DSP), a multimodal strategy, which for the first time will link distinct cellular neighbourhoods within biological samples to functional proteome states. DSP will combine multiplex immunofluorescence imaging and machine-learning driven cellular neighbourhood profiling with single-cell sensitivity mass spectrometry (MS) based proteomics. Our preliminary data support the feasibility and strong potential of DSP to uncover novel disease mechanisms, drug targets and predictive biomarkers. After development and rigorous benchmarking, we will apply DSP to an already available retrospective cohort of advanced head and neck squamous cell carcinoma, where response rates for anti-cancer immunotherapy are only below twenty percent. The correlation of cell states and spatial neighbourhoods with clinical outcomes will allow us to identify cell communities of highest likelihood to be critical for treatment response and hence patient survival. Through their functional characterisation by deep MS based proteomics, we will not only gain unique biological insights into immunotherapy resistance and potential therapeutic targets, but also identify predictive candidate markers to improve patient stratification. This new concept will have strong implications for basic and translational research, far beyond the study of cancer immunotherapy. DSP could
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'An Account of Legal Obligation'.

assistant: **Objectives**

This research project addresses an important legal issue, that of legal obligation. The notion of legal obligation features centrally in legal practices and studies, since law and obligation are widely regarded as closely connected by virtue of the authoritative structure of law.Now, any explanation of legal obligation aspiring to some degree of comprehensiveness must explain both the nature of the obligatory force of law and its foundation. That is, an account of legal obligation has to elucidate both what enables the law to hold us bound to do anything and why legal requirements should be taken to be binding. In working toward an explanation of legal obligation, thus, we must operate on two levels, identifying on the one hand a concept of legal obligation, and on the other the basis of the obligatory force of law. This two-pronged exploration sets up a number of questions for us to address: in conjunction with the definitional question “What is legal obligation?”—or “What do we mean by obligation and how does it apply to legal contexts?”—we must also ask “Why ought one to do what the law requires?” and “Whence does the obligatory force of legal requirements come?” or, stated otherwise, “What makes the law binding?”These are the questions around which the project is framed: they are tackled by working together into a coherent whole a theoretical investigation and a practical one. Each feeds into the other, since the very concept of legal obligation is clarified by showing how obligation makes its way into the practices out of which law is made, a process through which we can show what the obligation-imposing capacity of law rests on and where it comes from. In this way we can arrive at a comprehensive conception of legal obligation—the ultimate aim of this project—that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Spatio-temporal measurement and plasma-based control of crossflow instabilities for drag reduction' (GLOWING) targeting Horizon 2020.

assistant: **Abstract**

Delay of laminar-turbulent flow transition on aircraft wings can potentially reduce aerodynamic drag by up to 15%, reducing emissions and fuel consumption considerably. The main cause of laminar-turbulent transition on commonly used swept wings is the development of crossflow (CF) instabilities. Despite their importance, our fundamental understanding of CF instabilities is limited due to inability of current measurement techniques to capture their complex and multi-scale spatio-temporal features. This severely limits our ability to delay CF transition, which is further impeded by the lack of simple, robust and efficient control concepts.In this proposal I will achieve unprecedented spatio-temporal measurements of CF instabilities and develop a novel active flow control system that can successfully delay transition on swept wings. To achieve these goals, I bring forth a unique combination of cutting-edge technologies, such as tomographic particle image velocimetry, advanced plasma-based actuators and linear/non-linear stability and control theory. Spatio-temporal volumetric velocity measurements of CF instabilities will be achieved at three important stages of their life, namely inception, growth and breakdown, providing breakthrough insights into the underlying physics of swept wing transition and turbulence production. The results will be used to postulate and validate linear and non-linear stability and control theory models and provide top benchmarks for high-fidelity CFD. The unprecedented wealth of information, enabled through these advances, will be used to design and demonstrate the first synergetic plasma-based laminar flow control system. This system will feature minimum-thickness plasma actuators, able to suppress the growth of CF instabilities and achieve and