RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advancing Research & Innovation of FORTH in Green Soft Matter' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

A broad range of widely used industrial products, consist of complex Soft Matter systems (polymers, colloids, emulsions, etc.) made-up of synthetic ingredients of high environmental footprint. Urgent societal needs, embodied in the European Green Deal, require the replacement of synthetic components by Green, environmentally-friendly counterparts. The transition to Green materials is of vital importance for the transformation towards a sustainable eco-friendly production and a highly needed circular economy and sustainable growth.FORGREENSOFT aims at advancing the Research Capacity of FORTH in the area of Green, bio-based soft materials by transferring knowledge from three world-leading Institutions in the field of Green Chemistry (Max Planck of Colloids and Interfaces) as well as in specific experimental and computational methods (Max Planck for Polymer Research and University of Vienna). The later are vital in a leading research activity in Green Soft matter, but are lacking in the Host Institute. FORGREENSOFT research objectives will be achieved by a well-balanced training and personnel exchange program as well as a collaborative research program focusing on two key applications: Green antifouling coatings and water desalination membranes. In parallel, FORGREENSOFT aims at enhancing the networking activities of FORTH and improving its capacity to successfully participate in a wider range of EU calls, to attract industrial funding, and to promote innovation.  These objectives will be reached by transferring expertise from the leading partners, via the training of FORTH’s personnel in soft skills, and by local restructuring measures such as the creation of an Industry-Academia Liaison office focused on Green Soft Matter applications. Moreover, the leading partners will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Centre for Digitalisation of Biology Towards the Next-Generation of Biosustainable Products'.

assistant: **Objectives**

Biosustainablility is an important goal for humanity as it addresses many global challenges we face. We need convergence of different technologies and domains to tackle challenges of biosustainability and combination of digitalisation and biotechnology provides a powerful opportunity for this. While engineering of biology has delivered sustainable products, high-throughput generation of biological data has outpaced our capacity to learn from it. Digitalisation of biology, however, through exhaustive analysis of big data using integrated informatics approaches promises to deliver next-generation bioengineering solutions towards a green economy. These range from healthcare to biomaterials, new foods, and sustainable energy. To foster digitalisation of biology, we propose a Teaming partnership between the Novo Nordisk Foundation Centre for Biosustainability at the Technical University of Denmark (DTU) and the Estonian Centre for Biosustainability (ECB), that links leading universities of Estonia: University of Tartu and Tallinn University of Technology. The DigiBio project will significantly upgrade the ECB and will create a research and technology platform for data-driven disruptive bioengineering solutions to accelerate translation of science to manufacturing of next-generation bioproducts. The platform relies on complementary actions of partners for the generation and analysis of big data through integration of automated genome engineering, phenotype screening, high-throughput analytics, and informatics. It combines knowledge- and tech-transfer of a unique concept for digitalisation of biology and personnel training developed by DTU to ECB, a bioengineering hub of Estonia, and the success story of IT commercialisation and competence of Estonia. The project is aligned wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The roles of innate lymphoid cells and rhinovirus in asthma exacerbations' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Asthma exacerbations represent a high unmet medical need in particular in young children. Human Rhinoviruses (HRV) are the main triggers of these exacerbations. Till now Th2 cells were considered the main initiating effector cell type in asthma in general and asthma exacerbations in particular. However, exaggerated Th2 cell activities alone do not explain all aspects of asthma and exacerbations. Building on our recent discovery of type 2 human innate lymphoid cells (ILC2) capable of promptly producing high amounts of IL-5, IL-9 and IL-13 upon activation and on mouse data pointing to an essential role of these cells in asthma and asthma exacerbations, ILC2 may be the main initiating cells in asthma exacerbations in humans. Thus we hypothesize that HRV directly or indirectly stimulate ILC2s to produce cytokines driving the effector functions leading to the end organ effects that characterize this debilitating disease. Targeting ILC2 and HRV in parallel will provide a highly attractive therapeutic option for the treatment of asthma exacerbations. In depth study of the mechanisms of ILC2 differentiation and function will lead to the design effective drugs targeting these cells; thus the first two objectives of this project are: 1) To unravel the lineage relationship of ILC populations and to decipher the signal transduction pathways that regulate the function of ILCs, 2) to test the functions of lung-residing human ILCs and the effects of compounds that affect these functions in mice which harbour a human immune system and human lung epithelium under homeostatic conditions and after infections with respiratory viruses. The third objective of this project is developing reagents that target HRV; to this end we will develop broadly reacting highly neutralizing human monoclonal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Egos colloquium 2000'.

assistant: **Concept**

The EGOS (European Group for Organization Studies) organizes an annual conference, which is distinguished by its international participation and scholarly contribution to the forefront of organization theory. Besides the colloquiums' changing thematic groups, the EGOS Colloquium also allows for the establishment of international work groups to pursue research into issues of Particular interest to the European Community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Geochemical Provenance Mapping of Pre-Roman Ironworking sites in Britain' (IRONWORKS) under Seventh Framework.

assistant: **Objectives**

The IRONWORKS project combines innovative data analytic techniques with geochemical characterization methods to build a multi-element provenance database of smelting slag from primary iron production sites.  This work will add a critical piece to the iron provenance puzzle, allowing researchers to realize the promise of advances in slag inclusion analysis and test a robust series of artefact sourcing hypotheses across multiple elemental and geographic scales.  Investigations will focus on Pre-Roman Iron Age iron production sites in Britain, a region both known to classical authors as an exporter of iron metal and whose archaeological record is rich with 'currency bars' and other forms of trade iron.  Building on previous studies of variation in bloomery slag, this project will sample material from geologically defined and historically relevant regions; characterize their chemistry using inductively coupled plasma atomic emission and mass spectrometry (ICP-AES/MS); and explore their structure with multivariate statistical methods.  Specific objectives include determining the optimal element combination for discriminating slag at site, regional, and superregional scales, comparing the utility of various data treatments, and constructing a series of multivariate geochemical maps for facilitating artefact provenance investigations.  Provenance hypotheses will also be evaluated for a select group of previously sampled iron artefacts dated stylistically or contextually to the Pre-Roman Iron Age.  The IRONWORKS project will advance the state of the art in iron provenance methods, generate a practical and expandable database of slag chemistry and build a solid foundation for identifying extinct iron exchange networks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Production of phytoenzymes with proteolytical activities from european cultivated plants' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The anticipated project contains the production of phytoenzymes with prototypical activities from European cultivated plants in the steps of treatment - extraction, separation, isolation, concentration, preservation and further processing to production of enzyme products with application for nutraceuticals in foods or as raw materials for the pragmatics. Included are the detection and valuation of medical and health benefits and the harmlessness against allergies. The started co-operation between a German company of agriculture and processing industry and a polish company of pharmaceutical industry is a good combination to gain the anticipated objectives. A pilot plant is the presentable final result of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DNA Repair in Individual BActerial Cells' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Cells growing in identical environments can display substantial phenotypic heterogeneity within a population. This is partly due to changes in genetic information that in turn cause systematic changes in expression rates. It has also recently been shown that even genetically identical cells behave differently because many cellular processes involve molecules present in small numbers which causes significant cell-to-cell fluctuations. Genetic and non-genetic sources of heterogeneity may be connected through fluctuations in DNA repair enzymes such as the RecBCD protein of Escherichia coli and its functional analogue AddAB in Bacillus subtilis. RecBCD/AddAB is essential for DNA double-strand breaks repair and stimulates genetic exchanges. It is expressed at low levels, thus raising the question of how bacterial cells cope with potentially large cell-to-cell fluctuations in this complex. The objective of the project is to characterize the single cell heterogeneity of DNA repair in bacteria and to evaluate its impact on cell survival. We will (i) quantify fluctuations in RecBCD protein. (ii) Manipulate fluctuation levels to measure their impact on cell survival. (iii) Interface the experimental analysis with mathematical modelling to gain a better understanding of the system. (iv) Test the generality of the system by applying the above analysis to AddAB in B. subtilis. The results will shed light on a crucial cell process where fluctuations are expected to be substantial for physiological reasons, and of great selective consequence. The project will be developed the laboratories of Prof. Paulsson (Systems Biology Department, Harvard Medical School, Boston USA) and Dr. Noirot (MICALIS institute, INRA, Jouy en Josas, France). It will give the opportunity to the applicant to be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Unlocking Animal Food Quality Research Potential in Baltic Region by Developing Scientific and Technical Capacities of the Research Institute “Sigra”'.

assistant: **Innovation**

The scope of the project is  to develop S&T potential of the promising research centre of Latvia - Research Institute Sigra, in order to enforce high level research on animal feed and food quality in collaboration with research teams from other EU countries, as well as contribute to the development of research capacity of Baltic region and its integration in the European Research Area. Long term objective:  To stimulate realisation of full research potential of the enlarged European Union by unlocking and developing existing research potential in one of the convergence regions – Baltic. Short term objectives:  1.To strengthen capacity of researchers of the Research Institute Sigra to participate at EU level in the research projects and activities on animal feed and food quality. 2.To improve technical capacity of the Research Institute Sigra to carry out high quality research on animal feed and food quality and their impact on consumers health. 3.To promote collaboration with other research institutions in European Research Area, having similar scientific interest in order to use research capacity more synergetic and efficiently. Main activities planned: 1.Secondments of research staff. 2.Development of “Collaboration Research Program”.  3.Acquisition and development of research equipment. 4.Conferences and workshops, organised by the RI Sigra. 5.Participation in international exhibitions and congresses, in order to disseminate information about the project and the research institute. 6.Publishing and dissemination of the brochure. 7.Publications in scientific journals. Results expected: 1.RTD capacity and the quality of research upgraded.2.Better integration of the research team of RI Sigra in the European Research Area (ERA)achieved. 3.The capacity of RI Sigra for par
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Element accumulation on biofilms and daphnia from polluted surface waters using the txrf (total reflection x-ray fluorescence spectrometry)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Based on the investigations at biofilms and the zoo-plankton of German rivers and the results of the sediment- and water samples from the Szamos/Tisza longitudinal profile a methodology for biofilm analyses using the micro digestion procedure and the TXRF analyses is to be adapted. For identifying substantial biochemical processes of heavy metal accumulation on biofims and zoo-plankton reactor tests must be developed, planned, executed and analyzed. A training with the high sophisticated technical equipment and procedures is required to guarantee high quality data. Mathematically statistical procedures of the experimental design, as they are in use in the research group of water chemistry, will be tested to optimize the random conditions for the reactor tests. An emphasis will be the leaching procedure of Tisza and Szamos sediments. The leached water will affect the biofilms and zoo-plankton in biofilm reactors. In such a way maximum accumulation rates can be simulated, which occur with sediment re-mobilization and re-sedimentation during flood events. With the knowledge of the leaching experiment an optimized sampling strategy for biofims and zoo-plankton can be developed with non contaminated and contaminated sampling sites in the longitudinal profile of the Szamos and Tisza rivers. The analyzed natural biofilms and zoo-plankton from the Hungarian sampling provide the first indication regarding potential bioaccumulation of these elements within higher aquatic organisms. Additional tests with the biofilm reactors in the concentration range observed at the natural biofilms helps to understand the biochemical processes of element accumulation on biofilms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'New integrated approach for the optimisation of European flax products through the engineering of the process and material'.

assistant: **Concept**

In the last 50 years the basic flax spinning process has not changed significan tly. Consequently, the sequence of processing has therefore remained static and inflexible to the market. This is mainly due to inadequate technological knowl edge of the raw material, which is still assessed subjectively (organoleptic pa rameters). Since these assessments cannot be quantified, quantitative relations hips between the raw fibre and the end-product cannot be established. As a resu lt further technological developments to improve process efficiency and product quality have been inhibited compared to other textile fibres. The European ind ustry must maintain their prestige status of the quality mark (Master of Linen) from the growing competitiveness of the non-EEC countries, particularly from t hose of Far Easter Europe and Asia. EEC based manufacturers will have to improv e their technical knowledge to optimise the spinning and weaving processes by e mploying advance technologies as in other textile industries. (see Report 2 pub lished by Comitextil TOTAL QUALITY TEXTILE, within the textile Targeted Researc h Action - TRA). However, the problems associated with flax fibre characterisat ion are considerably more challenging than those encountered in cotton industry . The main objective of cotton processing is to select and grade the material into different qualities for use in specific process lines and products. In co ntrast, flax fibre has a more complex morphological structure, characterised by bundles of cellulose fibrils. These are cemented together by pectin, hemicellu lose and lignin, which have to be removed selectively during retting, chemical processing and wet spinning for various grades of yarn. This is the key to unde rstanding fibre quality and their effect on dete
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovative tools for membrane structural proteomics' (IMPS).

assistant: **Innovation**

Vast amounts of money are being spent on drugs acting on membrane proteins without knowledge of the molecular details of their mode of action. Even though the genes of membrane proteins are now accessible, solving their structure remains time-consuming an d often unsuccessful. Given their physiological and biomédical importance, this constitutes a major problem in basic life sciences as well as public health care. Tools have been developed to overexpress, solubilize, stabilize, purify and crystallize membra ne proteins, and they are currently being used in large-scale initiatives for structure determination. Unfortunately, most membrane proteins resist one or more of these steps. The objective of IMPS is to develop imaginative, broad-range tools for membrane structural proteomics. The project brings together experts in chemistry, biochemistry, molecular genetics and crystallography and aims at developing original, innovative tools to attack each of these stumbling blocks. A strong core of crystallographers wit h demonstrated expertise in membrane protein structure determination will apply these novel techniques to a representative test set of membrane proteins. The approaches to be developed include original overexpression systems (insect photoreceptor cells and the chloroplast), unconventional surfactants (amphipathic polymers, fluorinated surfactants, novel detergents and additives) and unconventional crystallization systems (lipid cubic phase crystallization, other non-detergent environments, molecular scaffol ding, bicelles). These novel methodologies will be made available to the community through a distributed technological platform including workshops, hands-on training, and dissemination of the new molecules, whose large-scale synthesis and distribution wil l be