RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Clinical biomarker and rapid diagnostic test for Staphylococcus aureus induced ventilator-associated pneumonia' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Hospital acquired infections such as ventilator associated pneumonia (VAP) are associated with unacceptably high mortality rates and spiraling healthcare costs.  Staphylococcus aureus (S. aureus) is a major human pathogen, and one of the leading causes of VAP and other nosocomial infections.  Vital to the effective management and treatment of S. aureus VAP is the use of appropriate antimicrobial therapies, and ideally prophylactic measures.  Antibiotic stewardship efforts, aimed to reduce the spread of antibiotic resistance, are resulting in changing clinical guidelines so the causative pathogen is identified before antibiotic treatment is initiated.  Such approaches rely on diagnostic measures to identify the infecting bacteria and resistance pattern, and usually take over 24 hours to complete.  Therefore, early identification of patients at risk of developing VAP coupled with characterization of the causative pathogen would allow early treatment and potential prevention, ultimately translating to reduced mortality and healthcare cost. The overall aim of this project is the clinical validation of a novel biomarker identified by Arsanis Biosciences to identify patients likely to develop S. aureus induced VAP.  In parallel, we aim to develop a unique rapid diagnostic test incorporating this biomarker and detecting other markers to characterize the bacteria, for use to at the bedside to identify these ‘at risk’ patients in the intensive care unit (ICU).  The test is aimed to give the ICU clinician rapid information to inform early clinical intervention.During the feasibility study we will assess the market and clinical utility of the diagnostic test through dialogue with KOLs, healthcare professionals and end users from a range of EU hospitals.  We will also validate the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dendritic cells as possible determinants for bone marrow restricted t cells activation and bone loss in Estrogen depleted mice' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Postmenopausal osteoporosis is a debilitating disease driven by estrogen deficiency. Bone loss is driven by an interplay of cytokines IL-7, TNFa, IL-1, IL-6, RANKL and IFNg. Activated, TNFa-producing T cells are critical for the increased osteoclast formation. The mechanism by which estrogen deficiency activate T cells is poorly understood.A major breakthrough was recently made by the finding that an autoimmune-like response is central to the maintenance of osteoclastogenic cytokine secretion by T cells, including TNFa. Preliminary data have revealed that bone marrow dendritic cells, but not spleen dendritic cells, are dramatically activated by estrogen deficiency. Hypothesis: dendritic cells resident in the bone marrow may undergo a site-specific activation in estrogen deficiency and, in turn, lead to an enrichment of activated T cells.Aim 1: To investigate in vivo the role of increased antigen presentation by dendritic cells in ovariectomy induced bone loss in mice. Strategy: OT-II transgenic mice bearing impaired T cell receptor are responsive only to the foreign antigen Ovalbumin and do not lose bone after ovariectomy. These mice will be injected with dendritic cells pulsed in vitro with Ovalbumin prior to ovariectomy. Physical analysis of bones and markers of T cells and dendritic cells activation will be evaluated.Aim 2: To investigate the role of chemokines as possible determinants of the site-specific activation of dendritic cells. Strategy: systematic evaluation of the profile of expression of some key chemokines and their receptors on T cells and dendritic cells will be performed in controls and ovariectomized mice. Subsequently, immunostaining on human specimens for dendritic cells and chemokines will translate findings on human model. OSTEODEN will allow a s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Universal Geometric Transfer Learning'.

assistant: **Concept**

In this project, we propose to develop a theoretical and practical framework for transfer learning with geometric 3D data. Most existing learning-based approaches, aimed at analyzing 3D data, are based on training neural networks from scratch for each data modality and application. This means that such methods, first, ignore the wider information overlap that might exist across different tasks and object or scene categories, and, second, tend to generalize poorly beyond the specific scenarios for which they are trained. Even more fundamentally, the majority of existing techniques are limited to problem settings in which sufficient amount of training data is available, making them ill-adapted in many practical applications with limited supervision.In this project, we suggest to take a fundamentally different approach to geometric data analysis: rather than designing independent application or class-specific solutions, we propose to develop a theoretical and practical framework for geometric transfer learning. Our main goal will be to develop universally-applicable methods by combining powerful pre-trainable modules with effective multi-scale analysis and fine-tuning, given minimal task-specific data. The overall key to our study will be analyzing rigorous ways, both theoretically and in practice, in which solutions can be transferred and adapted across problems, semantic categories and geometric data types.Such an approach will open the door to fundamentally new tasks and modeling tools, applicable to any geometric data analysis scenario, regardless of the amount of training data available. This would allow, for example, to track the evolution of biological systems, by studying the underlying complex 3D shape dynamics, or to analyze variability in object and scene collec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Computerized Automotive Technology Reconfiguration System for mass customization'.

assistant: **Objectives**

Automotive enterprises are becoming more customer-centric to meet today's challenging market demands. Thus, mass customization adds industrial value to the enterprise in gaining competitive advantage. The automotive industry has furthermore become highly networked and requires improved communication on products and components in its B2B relations. In this context, CATER is tailored to bridge the gaps in existing ICT through an integrated system that caters to the needs of customers, manufacturers and suppliers.There are three major aspects of the proposal. First, CATER is a design philosophy and showcases best practices of networked business. The goal of n-business is to achieve at mass customization over the Internet through coherently integrating manufacturing production automation with supply chain management and sales-service support into a collaborative web. A suite of innovative solutions for n-business will be developed in CATER.Second, CATER introduces ICT innovations in various business processes. The innovations include: citarasa engineering, 3D do-it-yourself design system with virtual reality interface, teardown reconfiguration system, design history system, and integration of CATER databases within supply chain management.Third, CATER demonstrates the need for a semantic driven system that ties together customers and designers. Customers are supported in their online customization of cars; their affective and cognitive needs are addressed to provide e-catalogues of design options. Designers, on the other hand, need to be supported in their design activities through teardown and design history management systems so that they can provide reliable and timely solutions. CATER-generated semantics provide a common vocabulary and platform that connects and integra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ebola virus manipulation of the cellular stress responses' (StressEBOV), addressing dissemination and exploitation.

assistant: **Impact**

Ebola virus (EBOV) is a highly pathogenic filovirus that causes severe haemorraghic fever and killed over 11,000 people during the recent epidemic in Western Africa. Although potential vaccines and drugs are being tested, no treatment has been approved. Therefore, understanding the cellular regulation of EBOV replication is fundamental to develop novel treatments. EBOV is a nonsegmented negative-strand RNA virus for which research is limited to BSL4 laboratories. However, a recent reverse genetic system using tetracistronic transcription- and replication-competent virus-like particles (trVLPs) allows modelling of the entire EBOV life cycle under BSL2 conditions. The EBOV genome is transcribed and replicated by the viral polymerase complex but the regulation of these processes remains poorly characterised. EBOV RNAs can also trigger antiviral responses via cytoplasmic RNA-sensors RIG-I and PKR, the latter also promoting stress granule (SG) formation. While EBOV inhibits RNA-sensing, the impact of SGs on EBOV is unknown. Therefore, I will investigate the role of cellular stress responses on EBOV replication and their potential counteraction by the EBOV VP35 protein using the trVLP system. Firstly, I will analyse the impact of SGs on EBOV replication by overexpression and CRISPR/Cas9 depletion of SG proteins. Using a panel of VP35 mutants, I will also investigate its potential to counteract SGs by automated flow cytometric image acquisition (Imagestream). Secondly, I will identify the EBOV polymerase complex interactome during infection using two distinct proteomic approaches: co-purification with a VP35-GFP fusion protein(GFP-trap) and VP35biotin-ligase proximity tagging (BioID2). Candidate VP35 cofactors will be validated by biochemical interaction, CRISPR-knockout and l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for ''Feeling European'. The Visual Construction of EU Identity.' under Horizon 2020.

assistant: **Concept**

European Visual Identity - SummaryThis project uses virtual ethnography and semiotic deconstruction to critically investigate how the formation of a European identity is reliant upon political symbols with which EU citizens can emotionally identify, and suggests directions for reforming the Union’s ‘symbolic capital’1 to encourage greater citizen affiliation with the EU.


**Keywords:** EU, European Identity, Political Symbols, European Iconography, Numismatics, EU Flag, Cartography, Monuments, Visual Identity, Political Communication
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Anti-IgLON5 disease: From Neuroinflammation to Neurodegeneration' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Anti-IgLON5 disease is a recently described encephalopathy associated with a variety of neurological symptoms that can be life-threating. The clinical course is mainly chronic and the response to immunotherapies is suboptimal. The hallmark of the disease is the presence of antibodies against IgLON5, a cell adhesion molecule predominantly expressed on the neuronal membrane. Surprisingly, neuropathological findings on autopsies revealed the presence of an atypical neuronal brainstem tauopathy, establishing a link between neurodegeneration and IgLON5 antibodies. IGNITION aims to establish an innovative, interdisciplinary doctoral training program to foster the next generation of scientists at the interface of neuroinflammation and neurodegeneration. The unique program will train 13 Doctoral Candidates across four key objectives: 1) addressing clinical challenges in diagnosing and managing anti-IgLON5 disease, 2) investigating the role of neuroinflammation in neurodegeneration, 3) developing animal models for therapeutic testing, and 4) analysing the function of IgLON5 in health and disease. These objectives will be pursued using cutting-edge molecular, cellular, and in vivo techniques, offering a comprehensive research training experience with the support of leading biotech and diagnostic companies. IGNITION will advance our understanding of the mechanisms behind anti-IgLON5 disease, contributing to scientific innovation and providing tools for improved diagnosis and prognosis. The gained insights will extend to the broader field of neurodegeneration, offering potential breakthroughs for other tauopathies, including Alzheimer’s and Parkinson’s disease. Through its research and training activities,  IGNITION will foster scientific excellence, increase disease awareness, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Policy Formulation and Validation through non moderated crowdsourcing' to be submitted under Seventh Framework.

assistant: **Abstract**

Collaboration and crowdsourcing are the realities of today's public Internet. The so-called Web 2.0" represents a precious repository of thematic information, thanks to the heterogeneous content that is inserted daily and spontaneously updated by its users. Very recently, a big commercial interest has started to arise – especially within industries that manufacture consumer goods and services – in acquiring, classifying and managing all product related information that emerges out of Web 2.0 channels, thus going beyond the known capabilities of consolidated search engines. It would be possible to use this insight to information at multiple stages of the policy-life cycle to support the definition of the political agenda, the creation, the implementation and the monitoring of policy proposals.In this context, modern politicians could test, detect and understand how citizens perceive their own political agendas, and also stimulate the emergence of discussions and contributions on the informal web (e.g. forums, social networks, blogs, newsgroups and wikis), so as to gather useful feedback for immediate (re)action. In this way, politicians can create a stable feedback loop between information gathered on the Web and the definition of their political agendas based on this contribution. The ability to leverage the vast amount of user-generated content for supporting governments in their political decisions requires new ICT tools that will be able to analyze and classify the opinions expressed on the informal Web, or stimulate responses, as well as to put data from sources as diverse as blogs, online opinion polls and government reports to an effective use.To this end, NOMAD aims to introduce these different new dimensions into the experience of policy making by providing deci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Resolution of the hiroshima neutron discrepancy and the impact of dosimetric uncertainties'.

assistant: **Innovation**

The project will investigate systematic and random errors associated with the A-bomb dosimetry, and assess their impact on cancer risk estimates. Fast neutron fluences in Hiroshima will be determined retrospectively by extremely sensitive accelerator mass spectrometry, to reassess neutron doses of the A-bomb survivors (LSS cohort), and resolve thereby the' neutron discrepancy' in Hiroshima, which is currently one of the major sources of uncertainty in the derivation of risk coefficients. The results will, together with updated information on y-ray dosimetry, serve as the basis for an appraisal of the impact of dosimetric changes and dosimetric random errors on risk coefficients for y-rays and neutrons and on their Lincertainties. Sources of uncertainty in the LSS other than systematic errors in Hiroshima neutron dose estimates, such as different types of random errors in dose estimates, and modelling uncertainties associated with projecting risks to low doses and over time, will be assessed. Consequent uncertainties in the cancer risk estimates derived from the LSS will be quantified in terms of different carcinogenesis models (empirical and mechanistic).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'GLASS: Glass in Late Antiquity: Science and Society' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The GLASS Project builds upon excavations at Tell Basta/Bubastis (Egypt) where a large amount of Late Antique glass (appr. 2500 fragments so far, mainly 2nd – 7th cent. AD) has been excavated. Using this glass corpus as a case study, GLASS seeks to address the lack of research about Late Antique to Early Islamic glass from Egypt and its trade by combining archaeological, chemical, and historical methods.Five key research questions (=Milestones) – namely 1. glass supply and consumption in Bubastis 2. trade patterns 3. recycling issues 4. the status of glass objects and 5. glass imitation – will be addressed and result in databases, catalogues and articles (Deliverables 1-4). The project will be based at the UCL Institute of Archaeology and include chemical analyses of glass from Bubastis on site with a portable XRF, and of contemporary and provenanced glass from relevant UK collections by electron microprobe and LA-ICPMS.Based on my good understanding of artefact typology, archaeological context and analytical methods, I will combine chemical analysis and typo-chronological studies on the basis of archaeological excavations in order to gain new knowledge about Egyptian glass production, working, distribution, usage and trade in the Late Antique world. I will integrate these results into a larger discussion and draw conclusions concerning various economic, cultural, social and historical aspects of Egypt's glass use and consumption in the context of the Mediterranean glass trade throughout the Late Antique and Early Islamic periods. The project will thus pioneer broader directions of inquiry and new, interdisciplinary approaches to the investigation of past cultures.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Stratification, Management, and Guidance of Hypertrophic Cardiomyopathy Patients using Hybrid Digital Twin Solutions' in the context of a Horizon Europe call.

assistant: **Objectives**

Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease (prevalence 1:200 - 1:500), manifested by thickening of cardiac walls, increasing risks of arrhythmia, and sudden cardiac death. HCM affects all ages - it is the leading cause of death among young athletes. Comorbidities due to gene mutations include altered vascular control, and, caused by HCM, ischemia, stroke, dementia, or psychological and social difficulties. Multiple causal mutations and  variations in cellular processes lead to highly diverse phenotypes and disease progression. However, HCM is still diagnosed as one single disease, leading to suboptimal care. SMASH-HCM will develop a digital-twin platform to dramatically improve HCM stratification and disease management, both for clinicians and patients. Multilevel and multiorgan dynamic biophysical and data-driven models are integrated in a three-level deep phenotyping approach designed for fast uptake into the clinical workflow. SMASH-HCM unites 8 research partners, 3 hospitals, 3 SMEs, and a global health-technology corporation in collaboration with patients to advance the state of the art in human digital-twins: including in-vitro tools, in-silico from molecular to systemic level models, structured and unstructured data analysis, explainable artificial intelligence - all integrated into a decision support solution for both healthcare professionals and patients. SMASH-HCM delivers new insights into HCM, improved patient care and guidance, validated preclinical tools, and above all, a first HCM stratification and management strategy, validated in a pilot clinical trial, and tested with end users. Thus providing a cost efficient and effective solution for this complex disease. SMASH-HCM develops a strategy towards fast regulatory approv