RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'AGV nAvigation system based on flexible and innovatiVE UWB positioning' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The AGAVE project overall objective is the development of an advanced guidance system for Automatic Guided Vehicles, focusing on a next generation positioning system development, allowing indoor and outdoor goods transportation within the warehouse through a flexible material handling system. The AGAVE system is a free-range system allowing a high level of optimisation in the routes to be executed, being its performances superior to those currently available on the market. It will be an integrated system easily adaptable to production environment changes and able to improve the overall quality, reducing the total lead-time.The following outcomes are expected:1) A stand-alone plug-in positioning system, based on UltraWideBand technology, exploiting computational hardware commercialised by the company TimeDomain, with a time to market of about 15 months after project completion.2) A navigation system, installed onboard, based on the improvement of the existing systems.3) An integrated software for fleet management, route optimisation and integration with operating machines, installed on a fixed host.The AGAVE system main technical advantages are:- operate in a very wide warehouse (average indoor route: 150-200 m)- realise a very flexible system, easily adaptable to outdoor applications (expected average route: 4-5 Km)- be compatible with all AGV configurations, even platform carriers, which is currently impossible with laser based positioning systems- be compatible with all warehouse layouts, with narrow corridors or the occupation of the overhead volume now kept free to ensure line of sight conditions for laser systems- be easily manageable and configurable through an advanced user interface- well automate goods transportation logistic phase, ensuring a smooth functionin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A new tool for creating real-time music within computer games'.

assistant: **Concept**

Computer games are experiencing an incredible fast evolution. With around 2.2 billion gamers across the globe (25% of the European on-line population plays video games) the industry has a constant demand for new technology, essential to maintain players’ interest in a very demanding market. Music, as a crucial part in the computer games creation process, also requires the new videogame era: whereas old computer games were, in general, simple (often just requiring a single melody), current ones are deeply complex, with several plots and levels, and almost infinite potential scenarios. However, current approaches for music composition do not adapt to this non-lineal essence of games but are just based on looping static musical pieces for each game level. This results in repetitive soundtracks, uninteresting for players, and a time-consuming activity for composers, unable to create a soundtrack for every single potential scenario. Based on the previous success of our CALMUS technology (that facilitates real-time adaptation of music composition to diverse external stimuli), we now present CALMUSgaming. CALMUSgaming is an innovative tool for automatically creating and adapting music within computer games. Instead of the soundscape being perpetually repeated, it enables a constant and real-time adaptation of the background music, according to how game progresses and to the player's performance and actions. On the one hand, CALMUSgaming facilitates music composition for computer games: it automatically generates complex and dynamic themes saving up to 90% of composition time. On the other hand, it enriches players’ experience, as it changes constantly as the game progresses. ErkiTónlist is an Icelandic SME focused on promoting creative endeavours in music. Grown over the achie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The elucidation and manipulation of the biosynthesis of aminoglycoside antibiotics', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The emergence of methicillin resistant Staphylococcus aureus (MRSA) and the rise in the number of tuberculosis cases in the Western World, highlights the unrelenting increase in the number of bacterial strains resistant to known antibiotics. No new class of clinically useful antibiotics have been discovered in the last decade, therefore, to combat resistant strains modification of existing antibiotics must be vigorously explored. To achieve this it is proposed to use gene shuffling techniques to alter the producing strains biosynthetic machinery to make novel antibiotics. Aminoglycosides are a large class of clinically important antibiotics that includes such significant compounds as neomycin and gentamicin. The project will involve the cloning of some of the biosynthetic genes for butirosin; an aminoglycoside produced by Bacillus circulans . Butirosin has a unique amino acid bonded to it's deoxystreptamine ring that has be shown to prevent deactivation of this antibiotic by many of the enzymes that confer resistance against other aminoglycosides. It is proposed to exploit this observation by transfering the genes that are responsible for adding 2-hydroxy4-amino-butyric acid to Streptomyces strains that produce neomycin and gentamicin. This should produce novel aminoglycosides that will hopefully be active against the growing number of MRSA stains. Training content (objective, benefit and expected impact) The project will provide training in molecular biology, mechanistic enzymology and chemical synthesis. The impact of the work is potentially of great significance because of the problems of antibiotic resistance. Links with industry / industrial relevance (22) It is anticipated that any novel Aminoglycoside Antibiotic found by this resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Widespread Bacterial CORE Complex Executes Intra- and Inter-Kingdom  Cytoplasmic Molecular Trade', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The enormous versatility of bacteria enables the formation of multi-species communities that colonize nearly every niche on earth, making them the dominant life form and a major component of the biomass. Exchange of molecular information among neighboring bacteria in such communities, as well as between bacteria and proximal eukaryotic cells, is key for bacterial success. Yet, the principles controlling these multicellular interactions are poorly defined. Here we describe the identification of a bacterial protein complex, herein termed CORE, whose function is to traffic cytoplasmic molecules among different bacterial species, and between pathogenic bacteria and their human host cells. The CORE is composed of five membrane proteins, highly conserved across the entire bacterial kingdom, providing a ubiquitous platform that facilitates both intra- and inter-kingdom crosstalk. Our preliminary data support the idea that the CORE acts as a shared module for the assembly of larger apparatuses, executing this universal molecular flow among organisms. We propose to elucidate components, structure and biogenesis of the CORE machinery, operating during bacteria-bacteria and pathogen-host interactions. We further aim to provide an unbiased-global view of the extent and identity of cytoplasmic molecules traded via CORE including metabolites, proteins and RNA, and to reveal the criteria determining the specificity of the transported cargo. Furthermore, we intend to decipher the impact of CORE-mediated molecular exchange on bacterial physiology and virulence, and devise anti-CORE compounds to combat pathogenic bacteria. This study is expected to transform the way we currently view bacterial communities and host-pathogen interactions. We anticipate these findings to lead to the develop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Transcriptional regulation and cellular localization of mycobacterial cell cycle proteins during dormancy', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

In this project we propose to study the relation between the cell cycle and dormancy development in Mycobacterium tuberculosis (Mtb). The final aim is to increase the knowledge on dormancy development and to identify potential candidates for the development of antitubercular drugs specifically active in dormant bacilli. Mtb is a facultative intracellular pathogen able to infect the human lung for decades without showing any symptom. Following immunity suppression caused by age, diseases, or malnutrition, tubercle bacilli can reactivate to give overt disease. About one third of the human population is estimated to be affected by latent tuberculosis representing a huge reservoire for the infection. The lack of drugs efficiently active on dormant bacteria is a major problem in fighting this important disease. Conditional mutants unable to express important cell cycle regulators will be constructed and used to study their role in i) global regulation of gene expression; ii) cell cycle proteins cytolocalization; iii) latency development in vitro and in vivo. Additionally, a transposon insertion library will be used to identify new mycobacterial genes essential for survival to prolonged stationary phase, and their expression will be measured during progressive and latent infection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tunable htsc microwave devices - investigation of the tunability of cuprate / ferroelectric heterostructures', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content Modern radar and mobile phone systems have a great need of high quality tunable filters with very low response time. Unfortunately, the situation in this field has remained unchanged since the discovery of YIG ball tunable filters in the60's. In this technology, a change in the resonant frequency is obtained by variation of the magnetic field applied to the YIG. These devices can achieve good quality factors (of order 10,000) but their response time is poor (several microseconds). Moreover, as the limiting factor is the stabilisation time of the magnetic field, further reductions are not possible. One solution to reduce the response time is to use an electric effect instead of a magnetic one. Ferroelectric materials are good candidates for this task, allowing a variation of the resonant frequency of the filter as a result of a controlled change i in their dielectric constant. BaxSrl-xTiO3 in association with the superconductor YBa2Cu3O7 shows great promise for such systems as these materials exhibit a small lattice mismatch (02%) which is required for the optimal growth of the superconducting layer and hence for devices exhibiting the lowest losses. The feasibility of this type of device has been demonstrated but the filter characteristics, especially the quality factor, have to be improved. The aim of this project is the epitaxial growth of ferroelectric / superconductor heterostructures by pulsed laser deposition (PLD). The first step will be to optimise the dielectric properties of the ferroelectric and the surface resistance of the superconductor. The structural quality of the materials will be analysed both in situ by RHEED and ex situ by X-Ray diffraction, electron microscopy (TEM, SEM) and atomic force microscopy (AFM). The tunable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Learning and modeling the molecular response of single cells to drug perturbations' (DeepCell) under Horizon Europe.

assistant: **Objectives**

Advances in single-cell genomics (SCG) allow us to read out a cell’s molecular state with unprecedented detail, increasingly so across perturbations. To fully understand a cellular system, one must be able to predict its internal state in response to all perturbations. Yet such modeling in SCG is currently limited to descriptive statistics. Building upon my expertise in machine learning, I propose to systematically model a cell’s behavior under perturbation, focusing on the largely untouched area of drug-induced perturbations with multiomics SCG readouts. A sufficiently generic model will predict perturbed cellular states, enabling the design of optimal treatments in new cell-types. In a pilot study, we predicted gene expression changes of a cell ensemble in response to stimuli. DeepCell builds upon this approach: Based on a multi-condition, multi-modal deep-learning approach for both normal and spatially-resolved genomics, we will set up a constrained, interpretable model for the cellular expression response to diverse perturbations. The added flexibility of the DeepCell model versus classical small-scale systems biology models will allow us to interrogate the effects of combined drug stimuli and characterize the gene regulatory landscape by interpretation of the learned deep network.DeepCell provides unique possibilities to capitalize on cell-based drug screens to address fundamental questions in gene regulation and predicting treatment outcomes. As a proof of concept, I will identify targets that regulate enteroendocrine lineage selection in the intestine. I will set up a 500-compound single-cell organoid RNA-seq screen based on compounds from a spatial imaging screen across 200,000 intestinal organoids, both of which we will model with DeepCell. We will leverage tho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Joint Training and Research Program on Lifespan Regulation Mechanisms in Health and Disease' (HealthAge) targeting Horizon 2020.

assistant: **Abstract**

Aging is an inexorable homeostatic failure of complex but largely unknown aetiology that leads to increased vulnerability to disease with enormous consequences on the quality of individual lives and the overall cost to society. Although, aging is driven by limitations in somatic maintenance, it is also subject to regulation by evolutionarily highly conserved molecular pathways. Indeed, macromolecular damage may drive the functional decline with aging; however, a battery of conserved, longevity assurance mechanisms may set the pace on how rapidly damage builds up and function is lost over time. Human efforts over the last centuries have succeeded in substantially lengthening lifespan, allowing aging to become a common feature of western societies. However, The discouraging complexity of the aging process, the noticeable lack of tools to study it, and a shortage of experimentally tractable model systems have made it significantly challenging to unravel the molecular basis of the processes that cause loss of bodily functions and degeneration of cells and tissues with advancing age. HealthAge was carefully designed to create a joint European program of excellence in training and research with a core intellectual focus on the functional role of “Lifespan Regulation Mechanisms in Health and Disease”. To tackle this, HealthAge combines top-level, state-of-the-art and interdisciplinary research skills that range from basic molecular mechanisms and ‘omics’ level understanding to translational research and clinical applications. This interdisciplinary strategy will allow us to gain functional insight into the fundamental mechanisms regulating longevity as well as to develop a series of rationalized intervention strategies aimed at counteracting age-related diseases.


**Keywords:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The People's Heritage Showcase' (TPHS) targeting Fifth Framework.

assistant: **Abstract**

To build and trial a user-friendly web based system to automatically collect, create, collate and share visual and text based information from buildings and objects which children consider to be of historical interest. It will provide a scalable, centrally served data management system, with local access to simple digitising equipment. It will establish the viability of contributing to and exploring information from heritage sites.The project aims to build active online heritage communities, which engender trust, motivation, ownership, and user participation, through the creation of democratic, grass-roots extensions to existing cultural collections. The proposal grows from the success of our existing publishing partnership (Digital Time traveller series) and would re-purpose data structures produced for a national database of children's artwork (Walkers Showcase).Objectives:- To motivate young people to engage directly with cultural heritage activities through the use of appropriate interactive web technologies;- To encourage individuals to contribute, fostering aspects of inclusion, trust, motivation, ownership and participation;- To re-purpose an existing, centrally served, user-friendly, web based system that dynamically collects, collates and shares visual and text based information from buildings and objects, which children consider to be of historical interest, either now or in the future;- To provide a secure, free-standing, digitising installation allowing individuals to easily capture and enter objects into the system;- To add experiential context and meaning to key artefacts from local collections by presenting structured challenges for young people to contribute their ideas, experience and connections;- To network the heritage community around young people's
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'EGNSS Hull-to-Hull' (H2H).

assistant: **Concept**

The overall objective of the proposal is to address the need of the maritime community to safely navigate in close proximity of other vessels and objects, being stationary or moving. This will assist mariners in making correct navigation decisions. And further, this will be a fundamental requirement for autonomous vessels.To achieve this EGNOS and GALILEO is taken into use to measure position of the vessel. However, these systems in the most basic form provides the position of the GNSS antenna, whereas the mariner needs to know the location of the vessel’s hull relative to other vessels or objects in the area of operation. For efficient and safe operations, the location information must be provided with high precision and high integrity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biological Drivers of Sex Differences in Autism Spectrum Disorder' to be submitted under Horizon Europe.

assistant: **Abstract**

It becomes increasingly clear that male and female brains do not develop along the same path. These inherent biological distinctions can lead to sex-specific vulnerabilities and variations in how neurodevelopmental conditions manifest. A prime example is Autism Spectrum Disorder (ASD), where a consistently higher number of males are diagnosed compared to females (approximately four males for every female), thereby emphasizing the significant impact of sex. While diagnostic practices may contribute, compelling evidence suggests that intrinsic biological factors are key drivers of these differences. Previous research, including work from the Novarino Lab using ASD mouse models, has shown that female brains exhibit more pronounced changes in gene activity compared to those of males. These results highlight the importance of sex as a factor, but the underlying causes, whether they're linked to sex chromosomes or hormonal effects, are still unclear. This project aims to dissect sex-specific effects during a critical postnatal developmental period. By building on the existing ASD mutant mouse cohort in the Novarino lab and combining it with the Four Core Genome mouse model, we'll create a one-of-a-kind transcriptomic dataset that can separate the effects of genetic sex (XX vs. XY chromosomes) from those of gonadal hormones on brain development.  By achieving these goals, the project will yield the first genome-wide, cell-type-specific analysis of sex bias in ASD mutants, thereby advancing the field toward a mechanistic, sex-informed understanding of the disorder that ultimately could pave the way for sex-informed therapeutic strategies, moving beyond a one-size-fits-all approach.


**Keywords:** sex differences, autism spectrum disorder (ASD), mouse model, hormones, sex chrom