RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Controlling autophagy in the intestine to rejuvenate.'.

assistant: **Objectives**

Human life expectancy is continuously increasing worldwide. However, longer lives must be accompanied by the increased health of older people. Therefore, the scientific community has set a goal to understand the causes of aging and how to revert them, aiming not only at living longer but living healthier. With this proposal, using telomerase mutant zebrafish as a prematurely aging model, I aim to determine the interdependency between autophagy and aging. In particular, I will determine if modulation of autophagy can revert the causes of aging and improve organisms health span. Knowing that the intestine is one of the first organs that deteriorate during adulthood, I will alter autophagy specifically in the intestine to revert inflammatory and behavioral phenotypes of aged fish. Moreover, I will study specific diet-microbiome associations in the intestine that might affect intestinal integrity, autophagy, and organism aging. The outcome of this research will create high-quality new knowledge on the relationship between gut autophagy and individual aging and will provide guidelines for the development of new anti-aging approaches.


**Keywords:** Autophagy, Intestine, Telomerase, Zebrafish, Aging, Physiology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Energy efficient safe innovative fast ships and vessels'.

assistant: **Concept**

Utilising innovative unconventional air-cushion/air-lubrication techniques in combination with approved catamaran hull configuration, EFFISES set project goals beyond EU-level in most of KA's, for improvements in fuel and hull efficiency, improved performance, reduced emissions, wash/ wake and other environmental aspects. The consortium base the demanding project requirements and goals on resonantly conducted scientifical pre-studies/tests showing remarkable improvements over conventional hulls. Contradictory to most fast vessel developments EFFISES will use new technology with significantly higher potential for development and optimisation. Development of innovative propulsion and lifting fan /air-management" systems, as well as new design tools - virtual reality (VR) and advanced CFD - will be included. Human / learning aspects will be addressed through innovative VR-programs. Thirteen partners from nine European countries, leading names alongside SME's will contribute to achieve a breakthrough in fast passenger and cargo ship designs."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Optimal nutrition towards osteoporosis prevention: impact of diet and gene-nutrient interactions on calcium and bone metabolipm.' under Fifth Framework.

assistant: **Concept**

The overall objective is to investigate the influence of diet and its interaction with individual genetic variation on the metabolism of Ca and bone in order to reinforce the scientific base for dietary strategies for osteoporosis prevention in Europe. The project will apply state of the art techniques in human studies to investigate how diet (Na, Ca, protein, vitamin E) and individual genetic variation (genes for vitamin D receptor A polipoprotein E) influence metabolic processes of Ca bone. A dietary intervention studies will be carried out in postmenopausal women. One of those will also develop and evaluate a novel radio- tracer method for bone loss measurement in intervention studies in humans. Those studies will provide new information on the role of diet and genetic variability in the mechanism of development of osteoporosis and on how dietary strategies may be developed for its prevention.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Reducing animal experimentation in drug testing by human cardiomyocyte in vitro models derived from embryonic stem cells' (INVITROHEART).

assistant: **Innovation**

The objective of the proposal is to establish stable cell lines that reliably reflect human cardiomyocyte properties by the development of models derived from human embryonic stem cells.The aim is to deliver reliable in vitro models that could be used by the pharmaceutical industry to replace experimental animals in:-  investigations on pharmacological toxicity and safety of compounds in the drug discovery and development processes, and-  the testing of toxic effects of chemicals according to the new system of the Community on the Registration, Evaluation and Authorisation of Chemicals (REACH).In the pharmaceutical industry reliable in vitro cell models would contribute to replace current techniques with animal experimentation in the selection and optimisation of lead compounds and in documentation of a selected drug candidate before it enters clinical phases. In the toxicity testing of chemical substances replacement of animal testing methods can be attained as well.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Recombinant expression of the goodpasture antigen and characterization of its cell-adhesive properties'.

assistant: **Innovation**

Collagen IV is the major component of basement membranes. The human a3 chain of collagen IV contains an antigenic domain called Goodpasture antigen, ubicated in the non collagenous carboxyl-terminal region of the molecule (NC1), that is the target for the circulating immunopathogenic antibodies present in patients with Goodpasture syndrome. The gene region encoding the Goodpasture antigen generates multiple alternative products that retain the antigen amino-terminal region with a five residue motif (KRGDS). This motif is exclusive to the human alpha 3(IV) chain. The serine therein is the major in vitro cAMP-dependent protein kinase phosphorylation site in the isolated antigen and includes the RGD cell adhesion site. It has been postulated that its phosphorylation might play a role in pathogenesis and influence cell attachment to basement membrane. The folding of the NC 1 domain is determined by six disulfide bridges and is essential for Goodpasture antibodies binding and phosphorylation. We propose to produce recombinant natively folded Goodpasture antigen and its splice variants in eukaryotic cells in order to study its cell-adhesive properties and the role that specific phosphorylation and alternative splicing play in it.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Site Effects Assessment for seismic Regulations by developing and validating physically based methods' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

It is recognized that local site conditions may affect the seismic ground motion, in terms of amplitude level, spectral content and time duration, thus increasing the seismic hazard level. Improving the way these site effects are accounted for is therefore a major concern, balanced however by economical constraints, which emphasize the need for inexpensive though reliable methods. In that context a seismic code regulation approach is often more appropriate than a specific study because of its simplicity and wide applicability. Indeed, the seismic codes consider site effects through site classification mainly defined with Vs30 (time-averaged velocity over 30 m) and associated spectra. However, despite Vs30 wide use as a proxy to site effects, it is often criticized as it does not seem fully relevant. An alternative approach, described in Cadet et al. (2007), proposes to characterize a site by Vsz (time-averaged over the top z meters) and f0 (fundamental resonance frequency). It also provides an empirical amplification function completely described by these two parameters. This approach was gauged and tested on a wide Japanese dataset, and it was proved to provide a larger variance reduction that Vs30 alone as f0 includes information on deep geology, while Vs30 carries only shallow information. The goal of this proposal is to deepen, extend and design a practical implementation procedure for this new approach, with both short term (site conditions, microzonation studies), and longer term (next generation of building codes) applications, with different steps: a) defining a protocol to characterize a site with Vsz and f0, or a direct use of the Rayleigh wave dispersion curve b)providing an estimation of the site amplification by updating the amplification function, includin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Geographic polarization and economic growth' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The union between the 'new growth theory' and the 'new economic geography' is very promising. The two main perspectives are: - Why and how the economic organisation of space is affecting the growth process and how growth is changing the geographic structure of activities. - From an institutional viewpoint, the issue is to appreciate more accurately the impact of the (geographic) organisation of the decision making process on growth. Three different papers have been realised. Two of them deal mainly with the impact of different institutional regimes on the dynamics of urban systems. The third one explores the implications of the assumption of productive local public goods (infrastructure) within the theory of local public economics. The first issue of my future research agenda deals with the spatial propagation of innovations and information. Very little is known on how to enhance integration by favoring the propagation of spill-overs and to what extent it is desirable The practical applications of this are of interest for the definition of national and European industrial policies. The second topic is related to the the impact of the geographic organisation on the acquisition of human capital.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Exploring the Spin Physics at the Boundaries of Materials with Strong Spin-Orbit Interaction' in the context of a Seventh Framework call.

assistant: **Objectives**

I propose to investigate a new research frontier on spin physics at the boundaries (surfaces) of materials with strong spin-orbit interaction (SOI). Although the properties of these materials have been studied for more than half a century, researchers are just starting to grasp the richness of SOI phenomena that occur at them. SOI leads to surface and boundary states with unusually large spin splitting in simple heavy elements. It can also produce a nontrivial topology in band insulators that brings about metallic surface states with exotic spin textures that are protected by time reversal symmetry.Despite their fundamental and technological interest, information on the nature of charge transport at such states is scarce, while spin transport remains unexplored. I plan to use our cutting-edge expertise on all-electrical lateral spin injection and detection methods to unravel the spin dynamics in them, providing a wealth of information that could not be otherwise obtained. A comprehensive set of objectives will include material integration with ferromagnets and insulators, and innovative devices and measurement protocols. My team will gather information on injection, accumulation, scattering and relaxation processes of spins in the surface and boundary states. Complementary experiments will focus on current-induced spin-torque on a contacting ferromagnet and will address the question of whether spin-split metallic surfaces can enable spin information processing when deposited onto semiconductors.This is a highly challenging project, with a strong interdisciplinary nature across physical and material sciences that will open new avenues for the realization of exotic states of matter such as axions and Majorana fermions. While the research program is driven by the quest for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'AQUA-INTEL: Smart Underwater Networks for Enhanced Water Quality Management' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Water quality monitoring is essential for protecting aquatic ecosystems and ensuring safe water resources in the EU and associated countries. Traditional sampling methods provide limited data and are resource-intensive. Recent technological advances have enabled more continuous and automated monitoring approaches, but implementing comprehensive underwater sensor networks remains challenging. The Mediterranean region faces unique water quality issues due to its climate and human pressures. Only 40% of EU surface waters achieve good ecological status, with southern European countries particularly affected. The EU has prioritized real-time water quality monitoring through key directives. Smart underwater sensor networks offer potential for revolutionary monitoring capabilities, providing continuous, high-resolution data across diverse aquatic environments. These networks can enable early pollution detection, improve understanding of ecosystem dynamics, and support evidence-based decision-making. However, research challenges persist in network optimization, energy efficiency, and data processing. The AQUA-INTEL project aims to develop next-generation underwater sensor networks for comprehensive water quality monitoring in the Mediterranean and broader European context. As human pressures intensify, there's an urgent need to quantify, monitor, and mitigate pollutant impacts across multiple scales. Current monitoring efforts often fail to capture complex interactions in large, interconnected aquatic systems. Addressing these challenges requires interdisciplinary collaboration, combining expertise in sensor technology, data analytics, environmental science, and policy implementation. By developing innovative monitoring solutions, researchers and policymakers can enhance water
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'FAIRshare. Farm Advisory digital Innovation tools Realised and Shared' (FAIRshare), addressing dissemination and exploitation.

assistant: **Impact**

Electronic data generation, analytics and communication technologies potentially enable more accurate, faster and better decision-making on farms, with huge potential to improve agricultural sustainability. There is a major focus on digitisation by EU and national/regional policy-makers to ensure that digital innovation in agriculture keeps pace with other sectors and the benefits of digitisation are available to the wider farming community. However, there is a danger that digitisation and future innovations will be hampered unless the rural advisory community is mobilised to take ownership of digital tools and to advocate at the user interface.  This CSA will engage, enable and empower the independent farm advisor community,  through sharing of tools, expertise and motivations. FAIRshare has two main programmes. Firstly, WPs 1, 2 and 3 will gather an evidence base of the digital tools and services used internationally, leveraging the social networks of partner institutions that span  EU and non-EU countries. The inventory of tools will be accessible to end-users on an intuitively navigable online interface that has been co-designed using a multi-actor approach. Accompanying the tools in the online inventory  will be information, for instance short ‘good practice’ vignettes, on how the tools may be used/adapted for use. Secondly, WPs 4, 5 and 6 will generate and resource a participatory ‘living laboratory’, empowering advisor peers from across the EU to interact with the online inventory and, in a series of workshops, to exchange, co-adapt, co-design and apply digital tools. The FAIRshare 'living lab’ will enable advisors to address challenges to embedding digital tools in different advisory and farming contexts across the EU. Special focus will be on  co-designing powe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a sf6 alternative for electrical equipment (ALTERNATIVE SF6)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

SF6 is used in electrical utilities as an insulating medium. It has been identified as a greenhouse gas in the 1997 Kyoto protocol and emissions must be reduced. Current measures for reduction of emissions are directed towards more vigilant maintenance practices, but the search of alternative solution to the use of SF6must be envisaged in case of stronger constraints. The project aims at developing a green gas able to replace SF6 in electrical utilities. The methodology adopted is totally different from previous works. We will combine molecular modelling, Life Cycle Analysis and experimental works. Molecular modelling will be used to understand SF6 properties, to imagine and develop new molecules. New molecules will be synthesised for experimental tests. We will evaluate environmental impact and economical interest of the new insulating systems with LCA and costs analysis. It is then expected to identify an alternative system to SF6.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The Others in Me: the Impact of Others on Self-Conscious Emotions and Self-Understanding'.

assistant: **Objectives**

This research action at University College Cork (UCC) aims at shedding light on the intersection of 2 central human capacities: self-consciousness and sociality. The first concerns how humans relate to themselves, the second, how they relate to others. The overarching question that this project investigates, from a philosophical perspective, is how these seemingly distinct capacities are related to each other, given what is known in psychology. To answer it, the project focuses on a class of emotions that epitomize the intersection of these capacities: self-conscious emotions induced by others (""hetero-induced""). These emotions offer key insights into what it means for persons to be social, since in them we feel that others impact who we are. The project is divided in 2 parts, devoted, respectively, to how self-consciousness shapes sociality and how sociality shapes self-consciousness.This action has the following objectives. PART 1: Primary objective: to clarify what our capacity to experience such emotions reveals about the social nature of persons. Secondary objectives: to clarify the differences of ""depth"" among such emotions, their impact on behaviour and evolutionary relevance. PART 2: Primary objective: to illuminate the kind of self-understanding afforded by hetero-induced self-conscious emotions. Secondary objectives: to establish which dimension of the self is at stake in such emotions, which sort of insights we can gain through them and how relevant and reliable are these insights.This action combines my expertise in the philosophy of emotion with the expertise of my host environment at UCC in social ontology and moral psychology. The work programme includes dissemination and communication activities such as journal articles and an international workshop