RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ROLE OF LOCUS COERULEUS IN NEUROPATHIC PAIN' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The locus coeruleus, the main source of noradrenaline in the central nervous system, is a crucial step in both the descending and ascending pain modulatory systems which are compromised in neuropathic pain. Neuropathic pain is a chronic pathological condition arising from damage in the nervous system and that does not respond successfully to conventional analgesics. In fact, the first-line treatment approaches for neuropathic pain belong to drugs that modulate the activity of the locus coeruleus. In spite of this, LC role in neuropathic pain remains unknown.  Locus coeruleus neuronal activity is modulated, among others, by G-protein-coupled receptors, α2-adrenoceptors presynaptically located. Indeed, the activation of these autoreceptors by noradrenaline circulating in the milieu active G protein-activated inwardly rectifying K+ channels (GIRK), hyperpolarizing the cell and inhibiting the release of the own neurotransmitter at LC level and projecting areas such as the spinal cord. This is a physiological feedback mechanism that control noradrenaline extracellular levels and consequently pain threshold. Thus, α2-adrenoceptors and GIRK channels seems to be a significant player in the locus coeruleus action potential frequency and therefore in the noradrenaline synaptic concentration. Thus, we suggest that they will play an essential role in ascending and descending pain transmission involved in neuropathic pain and that the knowledge of physiological processes responsible for their contribution to pain threshold will help to the design of a new line of anti-neuropathic drugs. We will tackle the project by implementing a broad range of techniques, from single-cell electrophysiology to whole-animal behavioural studies, and by correlating the results obtained by different te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Resurgence in Emergence: Stokes' Phenomena In Complex and Emergent Dynamics', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

We will use geometrical and analytical methods from wave physics to study exponentially small phenomena in dynamical systems. Many systems of interest in modern technology, from engineering to medicine, exhibit complex behaviours that arise from simple underlying laws -- a property called emergence. These can have huge consequences for a system's dynamics, causing instability and unpredictability. But the origin of such behaviour can be exponentially small, known as ""beyond all orders"" because it lies beyond the precision achievable with standard analytical techniques. As such, many problems concerning whether emergent phenomena occur in important systems of interest remain unsolved. We will approach the problem from a fresh perspective, using mathematics such as stationary phase and Stokes phenomenon, first discovered in the 1840's, which have led to sophisticated ideas such as hyperasymptotics, discovered only recently. These methods are traditionally used to study wave problems in physics and provide insight into the geometry of exponentially small phenomena. They have been linked to the role of resurgence in dynamical systems, whereby exponentially small terms rise to prominence in emergent phenomena, but have not been applied systematically to these dynamical problems.The emergent phenomena of interest arise when intersections are broken between special asymptotically attracting/repelling solutions, called stable and unstable manifolds. When the intersection breaks the manifolds split by an exponentially small amount. The problem is to calculate the splitting between manifolds to determine whether any intersection persists. A non-persistent intersection can imply the onset of chaotic dynamics, while intermittent intersections can imply the existence of canards --
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Children’s Liver Tumour European Research Network'.

assistant: **Concept**

Liver cancer in the paediatric population is rare with an incidence approximately 1-1.5 per million population. The commonest tumour seen in the childhood population is hepatoblastoma (HB), usually seen in young children and infants. Much rarer (about 10% of paediatric liver cancers) is hepatocellular carcinoma (HCC), usually seen in the teenage population and sometimes associated with underlying cirrhotic liver diseases. The ChiLTERN project relates to topic PHC 18 ‘establishing effectiveness of health care interventions in the paediatric population’. The ChiLTERN project builds on a unique opportunity to undertake a comprehensive research programme linked to an ambitious global partnership which will see the single largest clinical trial (the Paediatric Hepatic International Tumour Trial - PHITT) ever undertaken in this population of patients, with several randomised questions in six subgroups of patients. ChiLTERN will allow us to move towards an era of personalised therapy in which each patient will receive the correct amount of chemotherapy and will undergo has the best surgical operation (surgical resection or liver transplant). By using both clinical and biological information, we can assign patients more accurately to risk groups based on their survival. Using genetic tests and biomarkers, we will determine those children who may be at risk of developing long term side effects (deafness, heart failure, kidney damage). In addition, biomarkers will allow us to monitor during therapy and detect toxicities early before serious damage is done so that we can adapt treatment and prevent these problems. Finally, we will be using imaging technology tools which will help our surgeons plan liver operations more safely and effectively. Ultimately ChiLTERN will allow us to c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Territorial Responsible Research and Innovation and Smart Specialization' to be submitted under Horizon 2020.

assistant: **Abstract**

Territories and regions have become during the last decades increasingly important sources of economic and innovation activity. Concurrently, environmental and social concerns have become increasingly important and there has been expanding discussion on the responsibility aspects of research and innovation especially on the European level. The project aims to implement RRI in the territorial level. For this end, various European regions are participating in the project. The regions are from different parts of Europe giving an opportunity to make visible and compare different politico-economic contexts and their effects on the implementation of RRI.  The project will: a) Map and analyze the territorial systems to understand what is the current role of RRI, and what are the drivers and barriers for a RRI related transition; b) Co-create with the stakeholders mechanisms and supporting elements for the increasing implementation of RRI; c) Support the organization of the pilots in the implementation of RRI; d) Organize opportunities for territorial actors to learn and have peer support from other regions internationally; and e) Support dialogue between different levels of governance of research and innovation on RRI. As conceptual and theoretical frameworks to understand the functioning of the regional system and to support change in the system, the project will utilize innovation systems related theories together with theories of systemic and organizational change.


**Keywords:** Regional innovation systems, responsibility, ethics, governance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Networked industrial design and control applications using genetics algorithms and evolution strategies'.

assistant: **Concept**

INGENET NETWORK OVERVIEWThe increasing complexity of design in Aeronautic, Automotive and Energy Industries requires more and more robust optimisation and control tools for solving simultaneously discrete, continuous and combinatorial difficult problems unresolved until now. Evolutionary Algorithms (EAs) are artificial intelligence techniques which mimic nature according to the survival of the fittest Darwin s principle. They randomly encode physical (quantitative or qualitative) variables via digital DNA inside computers and are known for their robustness to better explore search spaces and find near-global optima than traditional optimisation methods. For this reason Evolutionary Algorithms are becoming widely used in many engineering and sciences problems. The main goal of the INGENET Network is to bring together academic and industrial partners in order to evaluate and compare performances of recent evolution based methodologies and (parallel) softwares on selected test problems of industrial interest.The Network includes the following tasks:- specifying its main objectives and activities, with reference to the exploratory phase;- coordinating innovative industrial research on Evolutionary Algorithms;- updating continuously the electronic INGENET Home Page Newsletter on the World Wide WEB dealing with genetic information relevant to industrial applications;- installing an on going INGENET Database at INRIA Sophia Antipolis;- computing selected model and industry oriented test cases;- organizing once a year in Europe (the first in the Series scheduled in March 1998) a series of two-day Database Workshops bringing together node-partners to present, analyse, validate and synthesize electronic results of computation and innovative methodologies;- organising a EUROGEN Sh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Theoretical & Practical Comprehension of Heavy Metals Behaviour in Incineration Processes for the Reduction of their Emissions by their Recovery & their Valorization' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Objectives and content The pollution risk from residues of waste incineration is a real concern for the whole European Union and especially because of leaching of Heavy Metals. Solutions for more efficient fly ashes and slags treatments are therefore necessary. The main objective of the project is to develop validated tools for the automatic calculation of Heavy Metals (HM) repartition through the different (gas, liquid and solid) flows of incineration processes. That will enable to identify the most efficient recovery means for HM reduction in the solid residue. For this purpose a process configuration has been identified, aimed at controlling the HM flows and their recovery in a concentrated single drain. This basic configuration includes a direct oxydative combustion, a separated melting of slags and fly ashes, a condensation of HM vapors from the melting oven, a high temperature filtration and a recycling of the insoluble part (containing HM) of gas neutralization products. The programme will comprise: - Theoretical calculations based on equilibrium laws to simulate the distribution of HM in the successive steps of the process: different chemicals forms and phases for each HM. - Validation of the theoretical results by those provided by industrial operations as well as by demonstration runs on adapted existing pilots plants. - Integration of the equilibrium laws and thermodynamical data into a model aimed at calculating the thermal and material balances for each individual step of the process. - This model will be used and validated to describe HM behaviour throughout the complete process on different configurations including different options for each step. That will provide a generic tool for incineration process expertise and optimization with regard to the reduc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Quantum Flagship Coordination Action and Support' (QUCATS) targeting Horizon Europe.

assistant: **Abstract**

Quantum Technologies (QT) are now developing quickly and broadly in Europe, and the QT Flagship launched 3 years ago is part of a larger Quantum Fleet. This evolution goes together with a reinforcement of the move from the lab to real-world applications, and to industry involvement towards potential markets. The QUCATS CSA is designed to accompany this transition, with the main goals to foster an open and inclusive ecosystem at the European and international levels, to contribute to the development of QT benchmarks and standards, and to step-up training and education of a quantum aware workforce. These outcomes will be reached through the execution of five Work Packages, and their expected impacts will be to preserve the ownership sense built by the previous QT initiatives, now enlarged from labs to the European quantum industry; to make sure that a plurality of voices is consulted and heard, delivering a consistent scientific and political message on critical QT-related issues; and to guarantee that the new phase of the QT Flagship will be validated and supported by the largest possible scientific and industry community. A crucial issue is to allow researchers and policy makers to strike a balance between protectionism and full free trade, in order to keep going the worldwide exchange of ideas, ultimately leading to the conceptual and technological breakthroughs required for the full realization of the QT potential. This smart openness will make Europe more attractive for foreign companies, avoiding at the same time the move of QT companies to countries outside it. Particular attention will be brought to the coordination and development of international QT standards and regulations, and to new educational programs on a European scale, able to train QT specialists, well
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'De novo design of modulators for protein-nucleic acid interactions' (NAMPify) targeting Horizon Europe.

assistant: **Abstract**

Protein–nucleic acid (NA) interactions are fundamental to many cellular processes, and their disruption can lead to diseases such as autoimmune disorders and cancer. However, targeting NA-binding proteins with small molecules is difficult due to the “undruggable” nature of their interfaces. Recent advancements in computational protein design and deep learning have created new opportunities for the development of protein-based therapeutics. However, current methods struggle to design proteins that can effectively modulate or mimic the intricate protein-NA interactions directly. While some NA-aware models have been developed, they often underperform due to our limited understanding of protein-NA interactions and the scarcity of diverse structural training data. To overcome these challenges, I propose to pioneer the design of NA-mimicking proteins (NAMPs) capable of directly modulating protein-NA interactions with high specificity and adaptable functionality. I will develop computational methods that incorporate the structural and chemical features of NAs, and create NAMPs tailored to engage therapeutically relevant NA-binding proteins and regulate their activity. In addition, I will develop approaches to expand the structural data on protein-NA complexes using accelerated structure determination methods to refine NA-aware models. This will enable the design of NA-binding proteins with sequence- and shape-specific recognition. Lastly, to create molecular machines with complex functionalities, I will develop new methodologies for the de novo design of multi-domain proteins capable of adopting multiple, defined conformations—long considered a “holy grail” in protein design. By integrating these approaches, I aim to overcome the current limitations in studying and designing p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'An innovative business model: turning domestic used cooking oil into renewable “fuel” for education and entrepreneurship', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Used cooking oil (UCO) is an excellent feedstock for advanced biofuel production. In fact, the market for the conversion of used cooking oil (UCO) from the hospitality sector into biodiesel is well established. However, even though around 854,000 tonnes of used cooking oil is produced from households in Europe, the extremely promising market of domestic UCO is generally untapped. In Cyprus, this market gap is being addressed by an innovative project that, through a solution-oriented approach, has proven that a harmful waste can be transformed into a source of income and innovation for the most vulnerable groups of our society: children and unemployed youth. Project “Tiganokinisi” makes schools the collection hubs of domestic used cooking oil, with each student bringing oil from her/his household and neighbourhood. The profit from the sale of the UCO is returned to the school for the implementation of green technologies and infrastructure. The entire initiative is tightly coupled with educational innovation (formal, informal and non-formal education). The project, which overcomes several of the obstacles previously identified in domestic UCO collection and which can become self-sustained within 5 years, promotes resource efficiency and environmental protection, while creating jobs in a niche market of the green economy. It helps Member States meet several EU targets related to the Waste Framework Directive, Resource Efficiency and Renewable Energy. It has therefore attracted the attention of NGOs around Europe and the world. There is international interest to replicate its success, and therefore there is a business opportunity. As such, ISOTECH, aims to develop a “blueprint” that will allow the replication of Tiganokinisi in other countries, through a licensing/franchisi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Stimulation of innovation by transnational technology transfer' (SITTT).

assistant: **Concept**

The SITTT project will provide for the continuation of the operation of an IRC Project in Israel, based on past experience, concentrating on delivery of quality TTTs, achievement of in depth involvement of the Traditional Industries mainly SMEs in the te chnological improvement process, enhancement of the participation of research Institutes in the TT process, leveraging the TT process and devising new approaches to achieve improved performance. Special attention will be paid to less-favoured regions in Israel. IRC-Israel will provide cost-effective services that promote transnational technological co-operation, which are pertinent to the national needs, provided in coherence with national support programs and will be an active member of the Network of players, intent in improving the European Innovation performance. The structure of the predefined Work Plan will follow Continuous Activities such as contacts with clients, promotion of IRC services, dissemination of Technological Opportunities, and Perio dic activities such as organisation of Workshops and other events, delegations and staff exchanges. The main quantitative objectives include signing a total of 26 TTTs over the project's period, out of 100 Technological Matches, performance of 64 audits at SMEs (the Inwards TTs will address mainly the traditional industries, requiring technological upgrade) and publishing 375 Technological Opportunities. All RTD results from EU Community research, and from the ESA and EUREKA programs, available for 3d party exploitation, will be promoted and disseminated. IRC-Israel will address Innovation Financing as well as IPR issues. The project will be carried out by two organisations: MATIMOP-Israeli Industry Center for R&D (the coordinator) and MAI-Manufa cturers Association of I