RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ultrashort pulsed kW-class laser with unprecedented flexible GHz burst operation for high precision high-throughput industrial manufacturing' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The next generation of material processing machines need to deliver higher precision, throughput and flexibility. Current ultrafast laser technology has demonstrated applicability for enabling high precision micromachining, but current throughput is not efficient enough for widescale industrial manufacturing and the parameters of existing lasers are not flexible enough to consistently work in the optimal conditions necessary to minimize heat-affected zone while using all of the available laser power.  kW-flexiburst will develop a breakthrough laser technology using a new concept of <1 ps multi GHz seed oscillator operated in burst mode that will be amplified to 1 kW. This new oscillator can flexibly generate any burst shape, intra-burst number of pulses, at a quasi-arbitrary burst repetition rate and quasi-arbitrary intra-burst repetition rate within an unprecedented GHz range. The new range of intra-burst repetition rate, in the multi>GHz regime, will enable ultrahigh ablation rates. The flexibility offered in terms of pulse number (1 with high energy to >2000 with low energy) will also support flexible switching between optimal ablation and optimal ablation rate to achieve unprecedented laser micro-processing throughput.  The ability to continuously modify the repetition rates is an ideal tool for industrial production as it enables precise adaptation of the local fluence to match optimal conditions where ablation efficiency is maximal, heat affected zone is minimal and surface finish is best. kW-flexiburst will demonstrate this concept in applications ranging from transparent materials cutting and drilling to metal surface texturing. Closed-loop monitoring and advanced synchronisation will enable parameter optimisation for temporal burst shaping and spatial beam shap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High performance laser micro drilling machine for large Hybrid Laminar Flow Control suction panels' (HyperDrill) under Horizon 2020.

assistant: **Objectives**

The main goal of the Hyper-Drill project is the development of a laser micro-drilling machine prototype for the manufacture of Hybrid Laminar Flow Control (HLFC) titanium suction panels with dimensions up to 5 m x 2 m and able to fulfil the requirement of a production rate ≥ 300 holes/s. This includes the creation of knowhow in producing such kind of structures as a basis for the industrial manufacturing of HLFC leading edges. For this purpose, firstly an optimization of the most suitable laser based technologies and processing parameters for the micro-drilling process will be carried out. The single pulse micro-drilling (SPMD) and the percussion micro-drilling (PMD) techniques are the covered technologies in this proposal for the micro-drilling of titanium sheets. In contrast to other approaches, both techniques have been widely investigated and are able to provide the requested results described in the Call by demonstrating at the same time feasibility on large Ti panels. Obtained production rates with these methods are above 400 holes per second. Several technical as well as economical aspects will be analysed in order to determine the most suitable technique for different specifications and conditions. A machine prototype equipped with both micro-drilling techniques will be designed, assembled and tested for production of 5 x 2 m Ti panels. A tentative design of the prototype based on the Consortium previous experiences and expertise is provided. The proposed design allows future upgrades for further increasing production rates beyond those requested in the Call for proposals. Several features for quality inspection of the micro-holes such as machine vision systems as well as quality control by in-situ monitoring the laser working distance have been included. Finall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cyclometallated ruthenium complexes for photo-activated chemotherapy' (CylcoRu4PACT) under Horizon 2020.

assistant: **Objectives**

Chemotherapy is efficient in curing cancer, but most treatments are very hard to stand for the patient, and side effects limit treatment efficacy. Phototherapy is a promising alternative, where the toxicity of a light-sensitive chemotherapeutic compound is locally released upon visible light irradiation of the compound-containing tumour. Photodynamic therapy is already available in the clinic for oxygen-rich tumours; however, it fails when the oxygen concentration at the place of irradiation is too low. In this project I propose to synthesize new ruthenium-based photochemotherapeutic compounds containing cyclometallated ligand, and to test them in an in vitro model of hypoxic cancer. The presence of a carbon-metal bond is known to shift the light absorption properties of ruthenium polypyridyl complexes towards the photodynamic window, a wavelength range where light penetrates optimally into biological tissues. However, cyclometallation usually quenches the ligand photosubstitution properties of ruthenium compounds because it strongly modifies the energy of their excited states. In this project, I will introduce sterically hindering groups on the cyclometallated ligand to recover photoreactivity of the complexes while keeping light absorption at high wavelengths. The challenges of this project consist on the one hand in achieving efficient ligand photosubstitution reactions with cyclometallated ruthenium compounds, and on the other hand in minimizing the cytotoxicity in the dark while maximizing cytotoxicity after red light irradiation at low oxygen concentrations. The ruthenium prodrugs will be synthesized, their photochemical properties will be measured, and their cytotoxicity against human cancer cell lines will be determined in an in vitro model of hypoxic cancer. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'How do dynamic changes extracellular matrix guide regenerative events in Axolotl?' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

How do dynamic changes of the extracellular matrix guide regenerative events in Axolotl?To what extent the dedifferentiation of mature cells is an intrinsic property of the cells or a product of interaction with the microenvironment is an exigent question in the regeneration field. In this project I will assess what initiates the regenerative response with an emphasis on deciphering what components are important for formation of the blastemal stem cell niche. Specifically, I will address whether ECM actively regulates the limb regenerative response or is merely a bystander. Although the importance of MMPs and ECM components in limb regeneration has been reported several times, few attempted to understand the role of ECM as signaling hub rather than as a “passive wall”.To address this, I will use tools developed in the Tanaka lab and combine those with my ECM expertise. I will characterize active ECM components during several distinct stages of limb regeneration to create an ECM “atlas” depicting extracellular changes during healing. I will use the obtained dataset to identify proteins which are important for the regenerative response by depleting these factors during axolotl regeneration and by testing their ability to induce ectopic limb growth using the Accessory Limb Model. Lastly, I will attempt to translate the axolotl findings to the mammalian setting and facilitate regeneration in a non-regenerating context.Surprisingly to date, no systemic characterization of extracellular molecules has been reported in regenerative systems, nor was any axolotl regenerative cue yet successfully translated to mammals. Thus, this characterization and candidate identification have far-reaching implications for both development and regenerative biology.


**Keywords:** Regenerative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'eddy Retention of Eggs and LArvae in the Catalan Shelf' under Horizon Europe.

assistant: **Concept**

In the Northwestern Mediterranean Sea (NWMED), anticyclonic eddies (clockwise spinning flows) increase fishes’ eggs and larvae (ichthyoplankton, IP) survival rate by providing protection and nutrients.  However, the underlying dynamics of this retention and nursing mechanism remain not fully understood, preventing us from anticipating climate change effects on early life stages of strategic fish. RELACS aims to understand if and how climate change will impact the role of eddies in the survival of IP. Combining three novel tools to quantify the presence of these oceanic structures and I will identify the mechanisms by which these eddies retain and nurse IP. I will explore whether expected changes in future climate change scenarios could affect this mechanism. My interdisciplinary knowledge in physical and biological oceanography will be enhanced by addressing this challenge with data from two novel observing systems that will be available for the NWMED (namely, an array of High-Frequency coastal radars (HFR) and the recently launched Surface Water Ocean Topography (SWOT) altimetry mission), and by using an unprecedented set of NWMED numerical simulations. From the observational side, I will leverage my knowledge on  the SWOT altimetry data, and gain skills on HFR during my first secondment at Dr. A. Rubio’s team.  I will expand my modelling skills at the hosting institution and during a second secondment with Dr. L. Renault. Then, with the help of Coupled Model Intercomparison Project climate projections, I will develop a series of scenarios for the evolution of the early stages of fishes at the region to contribute to predict the expected changes in fisheries due to changes in the environment. Finally, I will transfer the knowledge of the outcomes to society by creating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Globalisation Informed by Sustainable Development' (GLOBIS).

assistant: **Innovation**

The objectives of GLOBIS are to synthesise from the scholarly debate in different disciplines, a theoretical foundation for reconciling the three global processes: globalisation, development and sustainable development. Our ontological assumption is that globalisation is an ongoing and in principle benign process, but a process that needs to be promoted and adjusted in relation to sustainable development. Development as a concrete and institutionalised process also needs to be carefully aligned with sustainability. Based on this comprehensive understanding we will analyse how the global flows of financial capital, people, goods and ideas are promoted, restricted and regulated through a number of important policy areas, such as: trade, agriculture and food, energy, transport, technology and innovation, and tourism, in order to identify the existing tensions in globalization, recognizing the trade-offs involved, and thus pointing to possible areas of reform in current policy practices and global institutions.  GLOBIS will serve to inform European policy processes on how to reconcile globalisation and sustainable development in order to promote ambition of EU to become the leading force in the world towards sustainability. This will be pursued through a number of thematic studies of important policy areas. The project will engage stakeholders from different sectors of EU and beyond in dialogues on concrete policy dilemmas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Signal transduction pathways for leptin - ob - receptor' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content OB protein, (also known as leptin), a previously unknown protein signal, is secreted from adipose tissue, circulate in the blood, probably bound to a family of binding proteins and acts on central neural networks that regulate ingestive behavior and energy balance. Leptin exerts its biological effect through its receptor (OB-R) belongs to the hematopoyetin/cytokine receptor superfamily class I. After the cloning of this receptor, occurred only one year ago, only a few studies have attempted to elucidate the signal transduction pathways of this receptor. For these reason there are numerous important questions remaining about the role of OB-R; moreover the knowledge of intracellular molecules that mediate signal transduction via OB-R are of tremendous interest. Our target in this project will be to highlight different aspects of the OB-R signaling determining alternatives to the initial JAK-Stat pathway in order to find connections with other intracellular mechanisms and also to define which of these signals, or as yet unidentified signals, is most important in body weight regulation. Our attention will be focused on: 1- Studies on alternative JAK-STAT pathways involved in OB-R signal transduction. Our aim is to demonstrate that Insulin Receptor Substrate-1 (IRS-l) and Phosphatydilinositol 3'-kinase (PI-3' kinase) are associated with OB-R and also if there is an activation of these two proteins through phosphorylation upon leptin binding. 2- Studies on identification of OB-R sequences involved in the signaling 3- Studies on the SHC-GRB2-SOS and RAS pathway probably involved in the OB-R signalling. Training content (objective, benefit and expected impact) The discovery and rapid characterization of the OB protein signal pathways could be sig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Electrochemistry with laser-heated electrodes', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The objective of the project is to use laser induced heating in electrochemical studies. By the use of short pulses, less than 10 ns, of high-power laser light (0.1-10 MW) it is possible to suddenly increase the temperature of an electrode surface. The electrochemical response to the change of the electrode temperature contains both kinetic and thermodynamic information. Since the change of the temperature takes place in a very short time scale it is possible to study very fast processes. On the other hand, for processes faster than the temperature change, thermodynamic information can be obtained from the analysis of the dependence of the potential drop with the temperature. We propose to apply first such a methodology to study complexation reaction of metallic cations with self-assembled monolayers terminated in functionalised groups. Such reactions have important applications for the development of sensors for electroanalysis of metals. Dependence of the complexation reaction on functional group, pH and the length of the alkyl chain can be studied with the laser induce temperature jump method.As a second application, we propose the use of ultramicroelectrodes for the study of the potentiostatic response to the temperature change. The use of ultramicroelectrode will allow the decrease of the cell time constant to the nanosecond time domain. Hence, in combination with the laser induced heating, ultramicroelectrodes can be used to study the kinetic of fast processes.The development of the present project would allow the introduction of a new technique in the electrochemistry group of Alicante, allowing the transference of knowledge acquired by the applicant during his fellowship in Oxford to the host institution. We expect to be able to set up this new technique properl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Anharmonic Semiconductors' (ANHARMONIC).

assistant: **Concept**

Recent studies of halide perovskite semiconductors (SCs) showed that they exhibit a unique combination of very-low defect density, self-healing properties and low exciton binding energies that result in excellent photovoltaic activity.I hypothezise that the fundamental property that sets the halide perovskites apart from conventional SCs and gives rise to their beneficial properties is strongly anharmonic lattice dynamics.Large amplitude, local polar fluctuations that result from lattice anharmonicity localize the electronic states and enhance the screening of electric charges within the material. In other words, in some aspects, halide perovskites behave more like a liquid than a crystalline solid.    Stimulated by the recent discoveries on halide perovskites, I aim to generalize our understanding of the relationship between lattice anharmonicity and the electronic properties of SCs. The potential outcome of this investigation will be a novel scheme to design SCs with desirable properties where lattice anharmonicity is used as a new material-engineering tool.    My strategy is to perform comparative studies in both inorganic ionic crystals and small-molecule organic crystals.We will use low-frequency Raman spectroscopy to quantify anharmonic lattice dynamics and compare between different crystals to identify the factors that induce anharmonicity in solids. Photoluminescence, reflectance, time-resolved terahertz and impedance spectroscopies will be used to probe the SCs optical properties, carrier mobilities and lifetimes, and their dielectric response. I expect to find that as anharmonicity increases, the dielectric response and carrier lifetimes increase while carrier mobility decreases.   Finally, we will develop a modulated Raman spectroscopic methodology that will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Tanaza OS: the operating system for open Wi-Fi networking devices' (TanazaOS), addressing dissemination and exploitation.

assistant: **Impact**

It is forecasted that by 2021, 53% of users will access internet through Wi-Fi. This exponential growth in demand for wireless internet connectivity has led to the need, for companies in most business environments, to upgrade their Wi-Fi networking infrastructure. Today, such upgrade requires extremely large budgets, which are mainly allocated to purchase vertically integrated, proprietary solutions provided by incumbent hardware vendors. Companies such as Cisco, Aruba and Ruckus/ARRIS aim at establishing lock-in barriers with high switching costs in order to make their customers dependent on them. This approach progressively increases Wi-Fi deployment costs for organizations, slows down innovation and ultimately ruins the Wi-Fi user experience.However, this is going to change, as proprietary closed stacks that lock-in customers are destined to die out like it happened in other industries, such as computer hardware in the 80s or mobile devices more recently: Windows OS could run on cheap or expensive laptops, desktops, servers.  In a similar way, Android OS can run on both low range smartphones or on high-end devices. Sooner or later the open paradigm gets through, breaks the vendor lock-in and hardware becomes a pure commodity. Tanaza thinks that the current market conditions allow the disaggregation of hardware and software to occur also in the Wi-Fi networking market and make the same disruption happen.In this H2020 project proposal, Tanaza introduces its latest innovation, TanazaOS: a Linux-based operating system for Wi-Fi networking devices. This Operating System runs on any white-box and open-hardware networking device, giving enterprises and carriers an unprecedented possibility to decouple their hardware choice from their software choice, with considerable cost