RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Chromosome structure and genome organization in early mammalian development'.

assistant: **Innovation**

The spatial organization of the genome inside the cell nucleus is tissue-specific and has been linked to several nuclear processes including gene activation, gene silencing, genomic imprinting, gene co-regulation, genome maintenance, DNA replication, DNA repair, chromosomal translocations and X chromosome inactivation. In fact, just about any nuclear/genome function has a spatial component that has been implicated in its control. We know surprisingly little about chromosome conformation and spatial organization or how they are established. The extent to which they are a cause or consequence of genome functions are current topics of considerable debate, however emerging data from my group and many other groups world-wide indicate that nuclear location and organization are drivers of genome functions, which in cooperation with other features including epigenetic marks, non-coding RNAs and trans-factor binding bring about genome control. Thus, genome spatial organization can be considered on a par with other epigenetic features that together contribute to overall genome control. The classical paradigm of early mammalian development arguably represents the most dramatic and yet least understood process of genome reprogramming, where a single cell undergoes a series of divisions to ultimately give rise to the hundreds of different cell types found in a mature organism. Study of pre-implantation embryo development is hindered by the very nature of the life form, composed of extremely low cell numbers at each stage, which severely limits the options for investigation. My lab has recently developed a novel technique called single cell Hi-C, which has the power to detect tens of thousands of simultaneous chromatin contacts from a single cell. In this application I propose to app
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Energy Efficient Ventilated Façades for Optimal Adaptability and Heat Exchange enabling low energy architectural concepts for the refurbishment of existing buildings' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

EVENT will develop, demonstrate and validate a cost effective, high energy efficient, low CO2 emissions, replicable, low intrusive, systemic approach for retrofitting of residential and commercial buildings, able to achieve NZEB retrofit standard levels, through the integration of an innovative adaptive ventilated façade system, including: • Embedded, breakthrough smart modular heat recovery units, which allow thermal storage mode • High efficient photovoltaic generation capability units • Cost-effective, easy to install, high performance adapted products for external thermal insulation • Energy efficient HVAC systems The developed technologies will be integrated in the ventilated façade, and a real time intelligent façade management system will control operation of the system based on meteorological prediction methods for forecasting in advance the decentralised electricity production and the energy (electrical and thermal) demand of the building enabling maximum RE usage. It will inter-operate with existing or latest state-of-the-art Building Energy Management System, to achieve optimum energy efficiency by reducing primary energy needs, CO2 emissions and peak loads, assuring at least the same comfort levels required by Member States Building Codes, at an affordable price. Foreseen impact will be:• Energy savings of more than 40%, by the holistic use of the ventilated façade, the heat recovery of ventilation air• At least a reduction of 40% of CO2 emissions, as a consequence of the achieved primary energy savings• Reduced thermal and electrical peak loads• Typical performance target of less than 25 kWh/m 2 year (excluding appliances)Use of heat recovery units, number of photovoltaic cells, natural lighting strategies, and insulation thickness; are variable depending o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'We are developing ground-breaking therapeutics to cure currently untreatable respiratory infections affecting children and the elderly' in the context of a Horizon 2020 call.

assistant: **Objectives**

Human respiratory viruses cause economic and health burdens worldwide because there are no effective therapies. We have discovered a novel approach to stop their infection. The human respiratory viruses parainfluenza (PIV) and respiratory syncytial (RSV) viruses cause economic and health burdens worldwide. While RSV is the number one cause of death in children under 5 years old, with over 33M new cases occurring annually worldwide, PIV is the cause of 4-5% of all respiratory infections and 6-11% of all hospitalizations. However, currently there are no effective therapeutics to treat these debilitating infections and the economic burden associated with RSV and PIV is estimated at more than $11B annually, also defining a multi-billion dollar pharmaceutical market gap. We founded ViRelieve - biotech company with the main purpose to develop much-needed therapeutics to treat infections caused by RSV, PIV and related viruses. ViRelieve is led by an experienced team with biotech business, finance and IP expertise, drug development experience from pharmaceutical companies, and top researchers in virology and chemistry. We have discovered weaknesses in two processes essential for the virus infection – virus entry and replication, and have developed novel approaches to block these processes and thus stop these viruses from causing disease. Our R&D program has led to several patents filed and issued for unique compounds that specifically target essential virus components and demonstrated their effectiveness in animal models. Thus, our therapeutics will specifically treat RSV and PIV infections and will be superior to the few existing solutions as well as future competitors. In summary, gathering a complete expert team, filling patents, securing exclusive licenses and demonstrating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Fragmentary Constitutions of Aristotle' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

One of the greatest minds of antiquity was no doubt Aristotle. He is usually studied or read as a philosopher. However, his entire life, Aristotle was also a researcher, fascinated by history. His most important historical work is his huge collection of Constitutions, which were a gold mine of unique information on the history and organization of the Greek city-states. Only the Athenian Constitution survives almost in its entirety. Of the other constitutions all that remains are ""fragments,"" i.e. citations in extant writers, and the epitome by Heraclides Lembus. There are many editions and studies of the Athenian Constitution, but nothing comparable is found for the other constitutions. Therefore, my project will focus on the fragmentarily preserved constitutions, more specifically the 44 constitutions which were also included by Heraclides. My aim is to define the content and structure of the fragmentary Constitutions, study the link with Aristotle’s political philosophy, explore his reception and the relation to other ancient writers and identify the sources, method, historical value and authorship. For this purpose I will make an edition, translation and commentary of the fragments, which will be published as a book by Brill. This research will fill a major research gap in our knowledge of Aristotle’s lost works and his impact on western civilization. The Constitutions also offer valuable information on the political system and culture of many Greek cities. Ancient Greece is usually considered the ancestor of our modern democracy, but the reality is much more nuanced than we often make it out to be. The Constitutions can help us better understand the ancient world, which may serve as a mirror for modern discussions about justice, power, autonomy and government. LMU
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Role of Meis1 in the embryonic megakaryocyte lineage and vascular development' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

The main aim of the present project is to provide the first description of embryonic megakaryocyte function during vascular development and maintenance. The recent description of embryonic megakaryocytes existence together with the presence of vascular defects in all mouse mutant models that lack embryonic megakaryocytes suggests that a cellular interaction between embryonic megakaryocytes and endothelium is essential for the correct patterning and stability of the vasculature. The vascular system is the first organ to become functional in the embryo and its regulatory mechanisms are of ultimate medical importance in cancer, development, homeostasis, healing and regeneration. Likewise, blood and endothelium develop in close association and it is surprising to realize how little we know on how specific haematopoietic lineages support the development of a functional vasculature. We will address this important issue by characterizing the function of Meis1 in the megakaryocytic lineage and of the megakaryocytic lineage in vascularization. Meis1 mutant mice are the only known mutant mice that lack embryonic megakaryocytes without another apparent haematopoietic deficiency. Therefore, Meis1 null mice present a unique opportunity to investigate this common denominator – absence of megakaryocytes – on all haematopoietic mutants that present vascular defects. We will achieve this goal by: 1) a detailed characterization of the Meis1 vascular defect using histological approaches and optical projection tomography; 2) imaging the behaviour and interaction of the megakaryocyte cellular equivalents and the endothelium in live zebrafish embryos; and 3) establish the role of Meis1 and of embryonic megakaryocytes in embryonic vascularization through the targeted elimination of this linea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Hellenic Innovation Management Techniques Initiative Project' under Fourth Framework.

assistant: **Concept**

The PROSEGIS project aims at the development and promotion of Innovation Management Tools to the Greek SMEs in order to improve their competitiveness.In more detail the consortium will :- promote tried methodologies which have been developed previously by various Industrial Research centres and which include:diagnostic tools,tools for strategy development,marketing and development of human resources,- train 22 consultants,- carry out 70 assignments on selected companies using the trained consultants,- monitor the activities and assess the impact on SMEs,- Interface with other similar national and Community programmes, to enhance the impact of the project,- promote and disseminate the results both out national and international levels.Diagnosis will be carried out using TOMOGRAPHIA" a software based, multi-responses tool, specifically designed to investigate the SME requirements in terms of Innovation ManagementThe project is run and managed by a consortium of Greek Industrial Research Centres co-ordinated by Athens University of Economics and Business."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Physical metallurgy of rolling contact fatigue' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

SKF Engineering & Research Centre is the SKF Group' central research and development facility. With 120 employees of various nationalities, its role is to strengthen SKF's technical leadership in rolling bearings and seals. For the Materials Theory & Testing Function we are looking for post-doctoral Fellows (2 positions) in the framework of the Marie Curie Industry Host Fellowship. Job profile: Job holder's working field will be in inter-relations between (steel) metallurgy, microstructure, inclusions and mechanical properties, job holder needs to have documented experience in that. This should also include a thorough understanding of dislocation theory and of the mechanisms behind fatigue crack initiation, crack propagation and fracture. The candidate should also have experience in scientific problem solving, that is, the combined use of experimental and theoretical tools to go to the bottom" of the problem and should also have an interest to maintain contacts with external R&D partners. Our requirements: University plus Ph.D. in physics, metallurgy or equivalent. Inventive, high level of personal involvement and energy. The drive and commitment to make things happen. Excellent communication skills, good ability in written and oral English. A self-motivated, communicative, team worker. We offer: A challenging job with worldwide contacts. Possibilities for further professional development and growth. A modern working environment. Good labor conditions. If you are interested and meet the above requirements, please send your application letter and CV to Sjoerd.Veenma&SKF.com (Human Resources). For additional job information you may contact Erik.VegterSKF.com (Project leader Materials Science) or Jos.Bras&SKF.com (Function Manager Materials Theory & TEsting). SKF ERC, P.O.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Developing Cryogenic Energy Storage at Refrigerated Warehouses as an Interactive Hub to Integrate Renewable Energy in Industrial Food Refrigeration and to Enhance PowerGrid Sustainability', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The CryoHub innovation project will investigate and extend the potential of large-scale Cryogenic Energy Storage (CES) and will apply the stored energy for both cooling and energy generation. By employing Renewable Energy Sources (RES) to liquefy and store cryogens, CryoHub will balance the power grid, while meeting the cooling demand of a refrigerated food warehouse and recovering the waste heat from its equipment and components.The intermittent supply is a major obstacle to the RES power market. In reality, RES are fickle forces, prone to over-producing when demand is low and failing to meet requirements when demand peaks. Europe is about to generate 20% of its required energy from RES by 2020, so that the proper RES integration poses continent-wide challenges.The Cryogenic Energy Storage (CES), and particularly the Liquid Air Energy Storage (LAES), is a promising technology enabling on-site storage of RES energy during periods of high generation and its use at peak grid demand. Thus, CES acts as Grid Energy Storage (GES), where cryogen is boiled to drive a turbine and to restore electricity to the grid. To date, CES applications have been rather limited by the poor round trip efficiency (ratio between energies spent for and retrieved from energy storage) due to unrecovered energy losses.The CryoHub project is therefore designed to maximise the CES efficiency by recovering energy from cooling and heating in a perfect RES-driven cycle of cryogen liquefaction, storage, distribution and efficient use. Refrigerated warehouses for chilled and frozen food commodities are large electricity consumers, possess powerful installed capacities for cooling and heating and waste substantial amounts of heat. Such facilities provide the ideal industrial environment to advance and demo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exploring the identity construction of IS members through linguistic markers in online discourse' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The proposed research (Islamic State identity construction through discourse or ISICD) will explore the discourse of the Islamic State (IS) with the aim of contributing to a system of detecting, tracking, monitoring and studying such discourse in the Internet. As a tool, language allows us to establish our relationship with people discursively, to represent and distort reality, and to convince those with who we communicate to act in a certain way. This makes it a valuable resource for exploring larger motives and ideologies that are not explicit at the level of the text itself. The growing popularity of IS and its global influence depends on the ability of its members to communicate and share information online. As a consequence, its social identity as a political and religious group is established through online language in particular. The research will be carried out with a triangulation methodology, incorporating corpus linguistic methods with a discourse analysis frameworkand systemic functional linguistics, to determine four specific objectives (O):  O1 how extremism is identified within language use through quantitative linguistic markers such as n-grams and collocations; O2 how extremism is identified through qualitative structural patterns such as transitivity, modality and appraisal;  O3 how the use of these linguistic traits explains rhetoric and persuasive strategies used by IS; O4 what these findings tell us about how IS ideology is represented discursively.  The findings from this research will provide a much-needed comprehensive account of the linguistic markers that characterise online identity of IS members. The project will develop original quantitative methodologies which will be transferrable to other contexts in which ideology is constructed in onlin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Rearm cultivated tomato with natural and durable resistance mechanisms from wild tomato species'.

assistant: **Innovation**

Insects are gaining resistance to commercially available pesticides and effective insecticides (e.g. neonicotinoids) are currently being banned. Consequently, there is a real threat that the EU vegetable production will be affected. Wild tomato species have the ability to defend themselves by producing natural defence compounds that have a toxic or repellent effect on insects. These compounds are produced and stored in glandular hairs (trichomes) on the plant stem and leaf surface. Extensive breeding in protected environments led to the loss of these defence compounds in cultivated tomatoes. It was previously shown that the introduction of the terpene 7-epizingiberene biosynthetic pathway from a wild tomato in trichomes of cultivated tomato results in an enhanced resistance to insects. However, the regulatory factors that govern the production of these defence compounds seem also essential for successful incorporation of ‘wild resistance’ into breeding material. Here, I aim to discover metabolic defence mechanisms present in the trichomes of wild tomato species that can be re-introduced into cultivated tomato with a focus on post-transcriptional regulation of biosynthetic pathways. I will evaluate insect resistance in a collection of wild and cultivated tomato accessions and associate phenotypic and transcriptional data via a Systems Biology approach. I will also sequence small RNAs and compare them quantitatively with messenger RNAs to identify post-transcriptional regulations. Next, I will follow a comparative genomic approach by mapping the selected transcripts to their corresponding tomato genomes to associate polymorphisms and resistance phenotypes. These results will be directly translated into molecular markers that the industry can implement in breeding programm