RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Structural investigations on the structure-function relationships of Aurora Kinases' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Aurora protein kinases belong to the family of serine/threonine protein kinases. They are evolutionarily conserved enzymes that regulate different aspects of cell division. In vertebrates, there exists three Aurora kinases namely, Aurora A, Aurora B and Aurora C. In contrast, the C. elegans and D. melanogaster genomes encode only for two Aurora orthologues, and the S. cerevisiae genome for a single one. Aurora kinases differ in length and sequence of the amino terminal domain (non-catalytic domain), but show considerable similarity in the carboxy-terminal catalytic domain. Interestingly, even in the presence of high sequence similarity the three Aurora kinases are localized in distinct locations and perform different functions.Aurora A is shown to play a major role in centrosome separation, centrosome maturation and in the stabilization of mitotic spindle assembly, while the Aurora B is important in the regulation of kinetochore-microtubule interactions. The function of Aurora A is conserved in human, Xenopus, Drosophila and C. elegans. Recent studies that include the crystallographic studies from the host laboratory showed the role of TPX2, an activator of human Aurora A in molecular recognition and regulation. Although the function of Aurora A is con served in human, Xenopus, Drosophila and C. elegans, there is no apparent homologue of TPX2 in their respective genomes. In a similar note, the Auroras A and B share very high sequence identity but their respective activators TPX2 and INCENP do not show a ny reasonable sequence similarity.The proposed project aims to understand the molecular machanism involved in the activation and regulation of Aurora A from C.elegans and Drosophila and of human Aurora B mainly using X-ray crystallographic methods. Since, Aurora proteins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Connecting Bronze Age Europe: High-precision Radiocarbon Dating 1700-1500 BCE' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Through synergies between archaeology and physics, JOINTIME proposes to provide the first reliable radiocarbon-driven grid synchronising critical parts of Europe, from Scandinavia over the Carpathian Basin to the Aegean, between 1700 and 1500 BCE. Building on mathematically advanced software pioneered by AU Astronomy & Physics (AMS unit), this time-geography will be used as a springboard to pursue answers to the main project question: when and where the Bronze Age was first consolidated as a geographical and culturally interweaving process. This will further prompt comparisons with prevalent macro-models and involves testing an alternative frame recently proposed by AU Dept of Archaeology: here the Bronze Age is conceptualised as an interconnecting web-like process, which unfolded decisively c. 1700-1500 BCE when large tracts of Afro-Eurasia became knit by bronze and by many other transactions. Jointime aims to pinpoint the mode, direction and intensity of sociocultural interactions in the decisive period of Bronze Age consolidation. The anticipated results will be ground-breaking in Bronze Age studies as well as beyond. The project is timely since advanced modelling methods are now available and rich data are merely awaiting targeted, systematic and explorative analyses.The training of Tibor-Tamás Daróczi as experienced researcher at AU will ensue along these interdisciplinary lines in tune with the objectives of the planned research. The training will follow a detailed scheme of supervision and courses, with a full integration into the hosting department of archaeology and with a transfer to the AMS unit twice a week: embracing elements from scientific statistics to culture theory. His academic network will complement the ones of the host and guarantee mutually benefi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Non-conventional methods for galanthamine bioproduction'.

assistant: **Concept**

The overall aim of the project is to achieve a stable and sustained reintegration of Dr Milen Georgiev at the Host Institute (Stephan Angeloff Institute of Microbiology). This will be reached through the implementation of the scientific project. The general objective of the scientific project is to create an alternative approach for galanthamine bioproduction. This aim will be achieved through interlacing the experience of the Host Institute in the field of plant biotechnologies and the knowledge obtained from Dr Georgiev, in the field of bioprocess engineering during his previous Marie Curie project. For the achievement of scientific objectives, different strategies for improvement of galanthamine and related alkaloid volumetric yields by Leucojum aestivum differentiated organ cultures will be applied (elicitation and two phase cultivation systems will be developed); the scaling up of the biosynthetic process will be performed in different type of bioreactors (columns, temporary immersion systems); and the bioreactor culture environment will be optimised.Within the frame of the project, the possibilities for the extracts from L. aestivum to inhibit acetylcholinesterase will be checked, and the metabolomic profiling of the cultures will be performed through modern methods (GC/MS, NMR). The data obtained will lead to the identification of new compounds with pharmaceutical activity and will also contribute to the understanding of the L. aestivum primary and secondary metabolism.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dynamical and structural properties of linear water Clusters: Long range Proton Transport in an ordered Water Phase' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The aim of this project is to provide an in depth analysis of linear water clusters, and their long range proton transport capabilities, from a quantum dynamics perspective, and to give a detailed description of their operation, in view of the envisaged technological relevance these systems may acquire in the near future. The project will first focus on the dynamical aspects of the Zundel cation, composed of two water molecules and an excess proton, the smallest system where the proton relay mechanism can operate. The research will be based on the extremely acurate Potential Energy Surface made available last year, which will allow for very detailed quantum dynamical investigations. Our goal will be to establish the factors governing the efficiency of the proton relay mechanism, drain of energy to non productive modes, energy loss to the supramolecular environment due to confinement. We will also focus on the photodynamics of the system, which breaks apart upon photoexcitation. The behaviour of the system under such conditions is not only important to proton wires themselves, but also to bulk phase and gas phase properties of water under irradiation. Last but not least, an important part of the project will be the development and coding of new algorithms that will allow for the quantum simulation of even larger systems. The development work will be done on the basis of the MCTDH program, under continuous development at the University of Heidelberg for more than 15 years. This will allow many more studies to be performed in the future, which adds an increased value to the project itself. The realization of this research proposal will allow an experienced researcher to complement his background and consolidate a position of professional maturity at an European level. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Smart fisheries technologies for an efficient, compliant and environmentally friendly fishing sector' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The objective of SMARTFISH is to develop, test and promote a suite of high-tech systems for the EU fishing sector, to optimize resource efficiency, to improve automatic data collection for fish stock assessment, to provide evidence of compliance with fishery regulations and to reduce ecological impact. SMARTFISH exploits technological developments in machine vision, camera technology, data processing, machine learning, artificial intelligence, big data analysis, smartphones/tablets, LED technology, acoustics and ROV technology to build systems for monitoring, analyzing and improving processes for all facets of the fishing sector, from extraction, to assessment, to monitoring and control. The SMARTFISH systems will:- assist fishermen in making informed decisions during pre-catch, catching, and post-catch phases of the extraction process. This improves catch efficiencies and compositions in fisheries across the EU, leading to improved economic efficiency while reducing unintended fish mortality, unnecessary fishing pressure and ecosystem damage.- provide new data for stock assessment from commercial fishing and improve the quality and quantity of data that comes from traditional assessment surveys. This provides more accurate assessment of currently assessed stocks and allow the assessment of data-poor stocks.- permit the automatic collection of catch data to ensure compliance with fisheries management regulations. The SMARTFISH systems are tested and demonstrated in several EU fisheries. This contributes to promoting the uptake of the systems by extraction sector and fisheries agencies. An interdisciplinary consortium with technology developers and instrument suppliers, fishing companies, research and fisheries management institutes and universities will realize SMARTFIS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Reconstructing Embodied Musical knowledge At the Keyboard' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The fundamental objective of REM@KE is to reconstruct the sound and the function of lost musical instruments and to develop new theoretical, empirical, and practical tools to explore the embodied musical knowledge emerging from the relationships between these instruments and their performers. Among the great variety of objects of the past that inhabit museums, musical instruments are in a category of their own: if kept silent, music cannot be; if played, their materiality is endangered. These instruments are at risk of being silenced forever, as their conservation becomes the priority. To ensure access for future generations, a radical intervention is needed, to comprehensively study how they sounded and played when they were new, as well as their design principles and construction processes, so that they may be reconstructed, played, and heard both materially and virtually. To investigate the sound of these objects, we have developed a new research framework ‘Cognitive and Digital Organology’ (CaDO) that builds new bridges between organology, performance practice research, and cognitive sciences. CaDO will study the people involved with music, the instruments producing the sounds (interlocked into a system that evolves over time), in a space that is social, material, and digital. Embodied cognitive science will be used to examine how resources from the bodies of builders, players, educators, and listeners determine their musical experiences, fostering new relationships that are formed and transformed in acts of musicking. Thus, CaDO can inspire richer understandings of the experiences of those who engage with historical musical instruments and their replicas. By reinterrogating the relationship between instrument, gesture, and music REM@KE aims to reclaim the sound of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A New Drive-by-Wire Technology for People with Disabilities and Industrial Applications' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

People with physical disabilities require adaptable systems to provide them with new reliable and easy to operate driving solutions, as they cannot drive using conventional car controls. They need an adaptation of standard production cars, which allows them to drive just as safe as a non-disabled driver. Current car adaptation solutions are enabled by drive-by-wire technologies, which consist of man-machine-interfaces (MMIs) and electronic driving systems used to compensate disabilities. With this technology, the driver does not have to use conventional controls such as the steering wheel, instead, driving is facilitated by individually adapted MMIs like joysticks or handlebars. However, current adaptive devices are unable to match the performance of conventional controls. There can be technical problems as time lags between the execution of a control command -e.g. steering- and the actual vehicle reaction, interference between command actions -e.g. steering and gas-, etc. The car usually does not react according to the driver’s expectations, so that learning to drive an adapted car is difficult and requires a long time. Overcoming these issues, joysteer3.0 is a novel drive-by-wire system offering the best drivability, safety and reliability standards for steer, brake and gas, allowing people with a wide range of disabilities the operation of a car. Its high modularity together with its new remote GPS-based capabilities address a new market segment for safety-critical industrial applications. Our business model will subsequently benefit from new revenue streams and our cost structure will be drastically improved. We have estimated that the successful accomplishment of this project will lead to an accumulated profit of €5.25M for the first 3 years of commercialization, w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tuning TDP-43 self-assembly to understand physiological function and dysfunction', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Neurodegenerative disorders are an enormous societal burden and we lack therapies that target these diseases at their origins. To develop therapies, we need to understand what goes wrong at the molecular level. I uncovered key mechanisms that cause RNA-binding proteins, such as TDP-43, to dysfunction and drive neurodegenerative processes. I discovered that RNA-binding proteins self-assemble into ribonucleoprotein granules that are the likely origins of RNA-binding protein aggregates. More recently, my group and I revealed aberrant phase transitions of condensed RNA-binding proteins occurring in disease and identified fundamental mechanisms by which such phase transitions are regulated in cells.In TDP-Assembly, I now want to find out why these proteins exhibit a self-assembly behavior that apparently risks pathological aggregation. My hypothesis is that self-assembly is essential for their many functions in gene regulation, and that different types of self-assemblies, e.g., small clusters or fluid or solid condensates, mediate different functions in cells. Using TDP-43 as a paradigm, I will test this hypothesis to ultimately understand the molecular basis of RNA-binding protein dysfunction in neurodegeneration.To achieve this goal, I will use synthetic biology approaches to rationally tune self-assembly of TDP-43 in cells. I will study how altered TDP-43 self-assembly affects its known molecular functions, i.e., regulation of transcription, alternative splicing, and translation. Transcriptome and proteome analyses will draw a systems biology map of altered TDP-43 self-assembly and might lead us to novel functions of TDP-43 self-assembly. Ultimately, I will address how TDP-43's self-assembly, and thus its functions, are altered by disease-linked mutations in neuronal cell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'MagnetIc NOzzle thruster with elecTron cyclOtron Resonance'.

assistant: **Innovation**

MINOTOR’s strategic objective is to demonstrate the feasibility of the ECRA technology as a disruptive game-changer in electric propulsion, and to prepare roadmaps paving the way for the 2nd EPIC call, in close alignment with the overall SRC-EPIC strategy.Based on electron cyclotron resonance (ECR) as the sole ionization and acceleration process, ECRA is a cathodeless thruster with magnetic nozzle, allowing thrust vectoring. It has a considerable advantage in terms of global system cost, where a reduction of at least a factor of 2 is expected, and reliability compared to mature technologies. It is also scalable and can potentially be considered for all electric propulsion applications, from microsatellites to space tugs. Although the first results obtained with ECRA have been encouraging, the complexity of the physics at play has been an obstacle for the understanding and development of the technology. Thus an in-depth numerical and experimental investigation plan has been devised for the project, in order to bring the technology from TRL3 to TRL5. The strong consortium is composed of academic experts to perform the research activities on ECRA, including alternative propellants, along with experienced industrial partners to quantify its disruptive advantages on the propulsion subsystem and its market positioning.ECRA’s advantages as an electric thruster technology can be a disruptive force in a mostly cost-driven satellite market. It would increase European competitiveness, help develop low-cost satellite missions such as constellations, provide end-of-life propulsion, and pave the way for future emerging electric propulsion technologies.The 36 months MINOTOR project requests a total EC grant of 1 485 809 M€ for an experienced consortium of 7 partners from 4 countries:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'NexaSphere: NexGen 3D Networks Spin Harmonies across 6G, AI, and unified TN/NTN.' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The vision of NexaSphere is to create a system capable of facilitating a 3D network of networks. This framework seamlessly integrates multi-path transmission to enhance multi-connectivity in an energy-saving manner, bringing together spaceborne and airborne platforms with terrestrial infrastructure. The main goal is to deliver societal benefits to the future European landscape, with a particular focus on mobile transportation (including air mobility, railway, and automotive sectors), smart cities, and communities beyond the year 2030.NexaSphere's primary objective is to conceptualize and develop advanced hardware prototypes and software algorithms for a sustainable multi-connected 3D network. This network will integrate radio and wireless-optical technologies, and enabling network orchestration through AI-driven programmability. Additionally, NexaSphere aims to extend the edge-cloud continuum into space, creating a Radio & Wireless-Optical Connectivity Continuum from short-range to long-range. By integrating scalable simulation models in a hardware-in-the-loop approach and conducting in-lab and relevant environment validation, NexaSphere seeks to demonstrate proof-of-concept for this TN/NTN unified network architecture, targeting a Technology Readiness Level (TRL) of 4-5. These demonstrations will showcase the benefits of the proposed architecture, particularly within the mobile transportation sector, covering aeronautics, railway, and automotive industries.


**Keywords:** Unified TN/NTN, Sustainable networks, AI-driven, Wireless Radio-Optical network, 3D networks, Multi-connectivity, NTN antenna, edge-cloud continuum, AI-based resource management