RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Immunological mechanisms of respiratory co-infections'.

assistant: **Objectives**

Despite the concept that infectious diseases are usually caused by a single pathogen, in reality, we are constantly challenged by multiple pathogens and growing evidence indicates that co-infections are a much more common event than clinically perceived. The respiratory tract is the first point of contact with airborne pathogens and the most common site for infections. Hence, human respiratory infections contribute to substantial morbidity and economic losses worldwide, resulting in approximately 2.5 million deaths each year. Recent findings have shed light on a crucial factor in the severity of respiratory infections: the role of co-infections. Considering the public health importance of respiratory infections and the scarcity of research on the impact of co-infections in the balance of immune defences, this project proposes to study the in vitro and in vivo effects of diverse parasitic, viral, and bacterial co-infections on different types of immune cells in the lungs, and comprehensively characterize tissue local microenvironment and host-pathogen interactions. Additionally, we will investigate the immunomodulatory effects of protozoan infections on vaccines and chemotherapy treatments and their impact on the protection against targeted pathogens. Objectives include: elucidate the molecular mechanisms underlying immunological responses in the lungs and the susceptibility to co-infections; investigate altered immune responses of vaccines and the changes in the response to co-infection after chemotherapy of the primary infection. In the end, this study will allow deeper understanding of respiratory co-infections that could pave the way for the development of improved diagnostic and prognostic techniques, as well as the potential for proposing supportive treatments and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dynamic Bright Code: Delivering digital content in offline environments by connecting unique LEDbased optical tags with mobile devices.' (2014-2020) under Horizon 2020.

assistant: **Objectives**

BrightCodes has developed Dynamic BC - an innovative mobile content delivery platform that connects real-life objects to online content. BrightCodes’ solution is based on a proprietary visible light communication technology (VLC) that uses LED lights to send digital information to mobile devices in a way not perceptible by the human eye. Dynamic BCs are ideal solutions for contactless payment systems and security access control infrastructures. First, they enable customers to complete contactless payments from any smartphone without the need for near-field communication, which is not available on all mobile devices. Moreover, Dynamic BCs are a safer alternative to QR codes. They transmit factory configured UIDs that are difficult to duplicate/alter, thus they are very secure. In the access control field, Dynamic BCs can be used to authenticate and grant access to authorized person who scans the LED-based tag with the phone, by sending tag ID and verifying the user data to a cloud server, which then operates a controller installed at the door. In a longer-term stage, to increase product scalability and internationalisation, BrightCodes aims to apply Dynamic BC solution also to Out-of-home (OOH) advertising and in-store retailers.The proposed work in Phase 1 of the SME instrument fits into the company overall plan to reach the market by contributing the financial resources needed to plan a fast sound product development plan and its market uptake.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Technology Evolution in Regional Economies'.

assistant: **Concept**

The creation and accumulation of knowledge are processes at the heart of technological change and economic growth. Attention has been directed at aggregate measures of knowledge production in regional and national contexts, but little consideration has been given to the properties of knowledge produced in specific places. How does the nature of knowledge that is produced vary over space, what conditions the scope of technologies generated in different locations, and how do these knowledge sets impact the performance of local firms and industries?To date, the way in which specific regional knowledge capabilities influence the evolution of local technology trajectories and thus shape geographies of economic prosperity have not yet been considered systematically. The objective of the “Technology Evolution in Regional Economies” (TechEvo) project is to address these significant shortcomings. Focusing on the evolution of scientific and technical knowledge, as indicated by patent, trademark and scientific literature records, the point of departure is the pan-European knowledge space for all 28 European Union member countries, plus Norway and Switzerland, over the time period 1981-2015. The knowledge space, based on the co-occurrence matrix of particular knowledge domains (629), maps the proximity of patent technology classes and enables the development of regional measures of knowledge specialization for all 1,369 (NUTS3) regions. Set in an evolutionary framework the investigation provides ground breaking insights into how innovative entities and individual inventors are embedded in social and cognitive local and non-local networks, and how regional technology trajectories are shaped through entry, exit, and selection processes. TechEvo will provide a wealth of indicators, mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Intelligent Lung Support for Mechanically Ventilated Patients in the Intensive Care Unit' under Horizon Europe.

assistant: **Concept**

Invasive mechanical ventilation (MV) is one of the most important and life-saving therapies in the intensive care unit (ICU). In most severe cases, when MV alone is insufficient, extracorporeal lung support (ELS) is initiated. However, MV is recognised as potentially harmful, because inappropriate MV settings in ICU patients are associated with organ damage, contributing to disease burden. Studies revealed that MV is often not properly provided despite clear evidence and guidelines. Furthermore, treatment decisions by the healthcare providers, especially regarding MV and ELS, often remain incomprehensible to the patients and their relatives, since flow of information from caregivers to patients is challenged by a number of factors, including limited time and resources, communication problems as well as patients? capacity to comprehend and memorise information. The project proposed herein aims at clinically validating and extending our IntelliLung Artificial Intelligence Decision Support System (AI-DSS) designed to optimise MV and ELS settings to improve the care of ICU patients, alongside caregiver-patient communication. Thereby, best practice evidence-based MV and ELS within safer therapy corridors for longer periods, faster weaning from MV, and improved survival could be achieved - even in non-experienced hands. Additionally, this project will improve the information flow from caregivers to patients and relatives in the ICU setting. Therefore, we will develop a digital solution that allows automatic generation of an extensive plain-language information package for patients and their relatives, communicating highly individualised information on diseases and knowledge-based disease-management strategies, thus facilitating high-quality current and subsequent care through
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'A Novel Drug Targeting Strategy for the Treatment of Inflammatory Bowel Disease: A Molecular Biopharmaceutical Approach'.

assistant: **Objectives**

A molecular approach will be applied to mechanistically target drugs - by exploiting phospholipase A2 (PLA2) - to diseased tissues in inflammatory bowel disease (IBD). PLA2 hydrolyses the sn-2 fatty acyl bond of phospholipids (PL), liberating a fatty-acid and a lysophospholipid. We have shown that by substituting the sn-2 fatty-acid of the PL with a drug, PLA2 may be exploited as a prodrug activating enzyme, liberating the free drug from the PL-complex. Further, PLA2 affinity to the prodrug and the intestinal permeability of the whole prodrug can be manipulated by the conjugate design. PLA2 expression/activity has been shown to be significantly elevated in tissues of patients with IBD - both Crohn’s disease and ulcerative colitis. We posit that since the activation of the PL-drug conjugate is PLA2 mediated, increased PLA2 levels in the diseased tissue will lead to increased free drug in the actual diseased tissues, accompanied by decreased drug levels in non-diseased areas, resulting in extended therapeutic index and improved drug therapy. The proposed research will mechanistically facilitate specific targeting of 5-aminosalicylic acid (5ASA) for proof-of-concept. However, targeting of other drugs will be enabled by the core approach developed in this research. The specific aims are: 1) to design and synthesize a library of PL-5ASA conjugates with different linkers between the PL and the drug moiety; 2) to evaluate the PLA2-mediated activation and the intestinal permeability of the prodrugs (enabling the design/synthesis of optimal conjugates), thereby to identify the most promising prodrugs; and 3) to develop an IBD rat model, to quantify PLA2 expression/activity in diseased vs. control animals, and to evaluate the leading PL-5ASA conjugates for in-vivo drug targeting,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Deciphering the cellular origin and evolution of malignant rhabdoid tumors' under Horizon 2020.

assistant: **Concept**

Introduction How tumors adapt to changing environmental conditions and treatment is a major unsolved problem frustrating effective therapy. Rhabdoid tumors are highly aggressive pediatric tumors with a low survival rate. They occur in multiple tissues, including brain and kidney, and likely originate as a consequence of aberrant differentiation during development. Understanding the origin of rhabdoid tumors and the relationship with normal development is crucial for investigating new treatment options. The almost certain appearance of therapy resistance, low mutation burden, and recent epigenetic profiling suggest the existence of epigenetic heterogeneity within rhabdoid tumors. We hypothesize that epigenetic heterogeneity within rhabdoid tumors underlies their aggressive behavior.   Goal I previously exploited organoid models and CRISPR technology to study colorectal cancer progression. My lab now developed a protocol to, for the first time, efficiently grow rhabdoid tumor organoids from patient tissue. We are in the unique position to identify the cellular origin of rhabdoid tumors and the key molecular mechanisms driving disease progression and therapy resistance.  Approach We will I) apply single-cell epigenomic and transcriptomic analyses on tumor tissue for in-depth characterization of the cellular identity and heterogeneity within rhabdoid tumors II) combine our unique rhabdoid tumor organoids with genetic lineage tracing technology to reveal clonal dynamics in rhabdoid tumor progression and therapy resistance III) perform retrospective lineage tracing using somatic mutations to track down the cell-of-origin of rhabdoid tumors.  Innovation Our integrative use of state-of-the-art technologies on unique patient-derived tissue and tumor organoids will provide compre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Function of C/EBP beta in bone development and bone tumourigenesis'.

assistant: **Concept**

CCAAT/enhancer binding protein (C/EBP) transcription factors regulate cell proliferation and differentiation in various cell types. Due to alternative initiation of translation, C/EBP alpha and beta are expressed as different protein isoforms, which may display antagonising biological functions. Disturbed isoform ratios are presumed to be involved in tumourigenesis. Recently, it was discovered that C/EBPs are expressed in bone tissue, and involved in bone-specific gene regulation. Preliminary data obtained with C/EBP beta deficient mice also imply a function in bone development and ectopic expression of the small C/EBP beta isoform suggests a role in bone tumourigenesis (osteosarcomas).The aim of this project is to clarify the biological function of C/EBP beta in both normal bone development and in osteosarcomogenesis. Bone specific functions of C/EBP beta will be investigated by means of histological, cell biological and molecular biological comparisons of wild type and C/EBP beta deficient mice. Mesenchym al stem cells derived from C/EBP beta deficient mice will be used to delineate in which stage(s) of osteoblast differentiation C/EBP beta is involved. In order to resolve the functions of distinct C/EBP beta isoforms in osteoblast differentiation and in tu mourigenesis, they will be ectopically expressed in osteoblasts.Knock-in mice that express only the small isoform of C/EBP beta were recently generated and will be analysed for alterations in bone biology. The advanced research training on molecular genetics in mouse models will take place at the MDC within a multidisciplinary setting where basic and clinical research meets biotechnology. The applicant, Jeske Smink, will acquire knowledge and skills in molecular genetics that are highly relevant in clinical studies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Engineering Spin-Splitting in Atomically Thin 2D Non-Centrosymmetric Crystals' (ACCESS) targeting Horizon Europe.

assistant: **Abstract**

The information technology and communication sector (ICT) has been undergoing remarkable progress fuelled by integrational advancements in its building blocks, the field effect transistor (FET). The FETs in commercials microprocessors still use more than half a century old energy-intensive conductance switching processes to perform logic operations. It is well understood that the inability to remove the dissipated energy in such switching process will eventually stop the ongoing downscaling of the microprocessors in the next few years. Spintronic-based devices, working by virtue of energy efficient switching the spin-polarization, are considered to bring a paradigm shift in logic operations. Such devices use charge-to-spin interconversion (CSI) which is maximized in materials with strong spin-orbit coupling (SOC). The main goal of ACCESS is to engineer inversion symmetry and SOC in vertical heterostructures of two-dimensional layered materials (2DLMs) to facilitate the CSI process. We shall fabricate dual gated hBN encapsulated FETs using the 1T' phase of transitional metal dichalcogenides and its twisted bilayers to tune symmetry and SOC. ACCESS will exploit the Edelstein effect and intrinsic Berry curvature dipole to generate current-induced magnetization and detect it via unidirectional magnetoresistance (UMR) and nonlinear Hall effect (NHE) measurements. The CSI in our samples will be further tuned by dynamically varying vertical displacement field and the charge carrier density in the channel. By this way, ACCESS will harness the topological properties of  2DLMs for applications in future spintronics devices, capable of magnet-free spin-to-charge interconversion. Besides its scientific goals, ACCESS also focuses on strengthening the researcher’s transferable skills
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Smart cuvette and portable Time-Resolved FRET  for fast analysis of milk' to be submitted under Horizon 2020.

assistant: **Abstract**

The aim of the I-Cuvette project is the development of a portable device based on biosensors capable of analytical quality to assess milk contamination at the first step of the collection logistics chain (farm,) with a favorable market price for the single analysis (comprising six target analytes: 5 different antibiotics in milk including: Beta-lactam, Quinolones, Tetracycline, Sulphonamide, Aminoglycoside; plus Aflatoxins). This will spare the transportation of contaminated milk. The I-Cuvette system may be used also at the delivery point of trucks collecting milk providing almost immediate results (10 minutes) and avoiding the need of laboratory confirmation tests in case of positive results.I-Cuvette will be developed by:- ISS BioSense (ISS) a new high-tech SME located in Naples, Italy created in 2008 whose mission is the use and the manipulation of molecules of biological origin to develop highly specific and sensitive sensors.-  Kontor46 (K46) is an Italian private company established in Turin in 2012 and specialized in high-tech hardware and software developments, as well as in R&D services for the industry. In the dairy industry, milk contamination can happen at any stage of the production chain from the farm to the shelf. The conventional methods of analysis used for milk allow a thorough analysis with very sensitive Limits of Detection, but with the main disadvantages of requiring specialized staff, being time-consuming and expensive, finally, they need to be performed in a lab structure. The analytical performance of I-Cuvette, thanks to the use of biosensors, is better than the conventional methods used in the milk sector, with greater operational potential due to sensitivity, selectivity, reliability, portability, no sample pre-treatment, short time to resul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project '2D materials enabled Wide spectrum image sensors and optical NEURAL network based low power consumption computer VISION' (2DNEURALVISION).

assistant: **Concept**

From the late 1950s, Computer Vision (CV), a significant field of artificial intelligence (AI), began to be the tool to realize human intelligence and perception. Today, the global computer vision market has a value of over $11 billion and will reach $19 billion in 2027. Current computer vision systems suffer from high power consumption and limited reliability due to the low amount of information captured and sensor malfunction in adverse conditions such as fog, darkness, and bright sunlight. The 2DNEURALVISION project aims to develop the enabling photonic and electronic integrated circuit components for a novel low-power consumption, any weather, any light computer vision system. These components are a 2DM enhanced wide-spectrum image sensor and optical neural network with enabling 2DM components. Non-toxic materials and new waferscale, CMOS-compatible back-end-of-line integration processes for 2DMs will be developed to show compatibility with high-volume markets. The developments in the 2DNEURALVISION project will result in reliable (any weather, any light), low cost (1000x lower), low power consumption (30x lower), and small form factor (1000x lower) computer vision systems. This will have enormous societal impacts by enabling disruptive improvements in the automotive, AR/VR, service robotic, and mobile device sectors.


**Keywords:** Graphene, Computer Vision, Low power consumption, Optical Neural Network, Complementary metal oxide semiconductor, Colloidal Quantum Dots, 2D materials, photonic integrated circuit, Image sensor, AI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Synchrotron radiation diffraction topography investigation of magnetoacoustic effects in weak ferromagnets' (1994-1998).

assistant: **Innovation**

There is currently a renewed interest in weakly ferromagnetic crystals such as iron borate (FeBO3) and haematite (a-Fe203) firstly, because they could be promising materials for data storage and processing systems in modern microelectronics and secondly because they display a range of novel non-linear phenomena. Such crystals are characterized by a strong interaction between the magnetic and elastic subsystems. So far, there have been preliminary studies on domain wall motion and non-linear effects using neutron diffraction and magneto-optic techniques. I wish to extend this work by taking advantage of the high resolution diffraction facilities of the ESRF to study the domain wall dynamics under an ultrasonic excitation and/or the application of an ac magnetic field. The pulsed nature of the x-ray source will also allow stroboscopic techniques to be employed for solving problems in magnetoacoustics and in the physics of non-linear interactions in solids.