RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Collective and cell-autonomous dynamics of the genetic oscillators of the segmentation clock in zebrafish somitogenesis' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The subdivision of the vertebrate embryo into repeating segments called somites, from which the muscles and bones will grow, is one of the oldest problems in developmental biology, recognized by Malpighi in the 1600s. This proposal focuses on the composition, function and dynamics of a population of genetic oscillators (termed the segmentation clock) that couples the spatial elongation of the embryo with the serial formation of somites. The research proposal outlines molecular, cellular, embryological and biophysical approaches to understanding these complex temporal and spatial phenomena in the zebrafish embryo. The work delves into three main areas: identification of oscillator components, control of oscillator frequency, and coordination of the oscillations in space and time. Novel methods and technologies to measure spatial growth rates, genetic oscillations, and signaling events in real-time in the growing embryo are proposed. Mathematical simulation and analytic physical theory to describe both morphological dynamics and microscopic biochemical mechanisms are to be developed in parallel with the biological experiments. The application of theory and experiment to the segmentation clock will give a unified framework in which to make and test physical theories of collective processes and their precision and robustness in developing systems. Coordination of the field of cells that gives rise to somites by synchronized genetic oscillations is a novel paradigm for patterning tissues, raising the possibility that genetic oscillations may be widely used in embryonic patterning, differentiation and morphogenesis. Analysis of the segmentation clock should provide the key concepts and methods to explore such systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Rac1 function in Intestinal stem cells' (Rac1ISC).

assistant: **Concept**

Diseases that affect the digestive system are the most common causes of mortality.The intestinal epithelium is a highly proliferative tissue, where most cells are replaced on a weekly basis. Intestinal stem cells (ISCs) are crucial for tissue maintenance and regeneration after wounding. Homeostasis within the stem cell compartment is controlled by extrinsic and intrinsic signals. The intrinsic cellular machinery that coordinates stem cell division, expansion and final differentiation is poorly understood and only little is known about the regulation of these pathways in vivo.The aim of our work is to understand the molecular mechanisms that control the behaviour of ISCs during tissue homeostasis in physiological and pathological conditions. We will focus on Rac GTPase signalling pathway: Is Rac1 involved in ISC homeostasis and tumour initiation? Which downstream signalling pathways are regulated by Rac1 activity in ISC in vivo? Does the loss of Rac1 modulate an inflammatory response in the intestinal mucosa?In the epidermis, Rac1 is essential for normal differentiation and maintenance of hair follicle stem cells, while under pathological conditions, Rac1 is crucial for keratinocyte hyper-proliferation in vivo. We will analyse the effect of Rac1 depletion in ISCs in vivo by generating Rac1 conditional KO in ISCs. In parallel we will generate Rac1 conditional KO in ISCs on Apcmin/+ mutant background and study Rac1 function during intestinal inflammation and tumour formation.The use of a multidisciplinary approach and the combination of in vitro and in vivo studies will help to explore our hypothesis of Rac function in the maintenance of a healthy intestinal mucosa. Characterising an intrinsic molecular mechanism that connects external signals from the microenvironment to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'De novo synthesis of a chloroplast genome in Nicotiana tabacum'.

assistant: **Objectives**

Despite significant progress in chloroplast biotechnology the de novo synthesis of a chloroplast genome hasremained elusive. The development of strategies to design, assemble and transform artificial chloroplast genomeswould signify a step-change in the field of plant synthetic biology. Only recently, genome scale DNA synthesisand sequencing has become routine, providing an ideal foundation to revisit the challenge of chloroplast genomesynthesis. I will join Ralph Bock, a world leader in chloroplast biotechnology, and combine the expertise of hislaboratory with my background in synthetic biology to generate the first Nicotiana tabacum plant with an artificialchloroplast genome. I will base my strategy on creating and testing multiple different genome designs with varieddegrees of structural and genetic code alterations in respect to the parental genome to identify viable designs. Iwill develop methods to assess those designs in parallel, permitting the rapid identification and fixing ofproblematic regions in the synthetic genome. I will proceed to assemble the verified chloroplast genomes in ahierarchical, parallelized manner from large pieces of synthetic DNA. Finally, I will characterize the phenotype ofthe resulting plants, focusing on understanding the changes in transcription, translation and metabolism. Themethods developed in this work will provide insights into the design principles of organellar genomes, and providea platform to reinvent and remodel the genetic code of chloroplasts. This work will thereby establish strategies tore-engineering complex cellular processes such as photosynthesis, or to design entirely new functions such as thegenetic isolation of synthetic DNA in plants.


**Keywords:** Synthetic biology, plant biology, chloroplast engineering, bio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Use of mycorrhizal fungi for the phytostabilisation of radio-contaminated environments'.

assistant: **Objectives**

Biological activities in soils are widely recognized as playing a vital part in nutrient cycling, element mobilisation and availability to plants. Among the soil microflora, mycorrhizal fungi occupy a unique location at the interface between soil and plant. Though they are recognized as key actors in the soil-to-plantcontinuum, their role in radionuclide (RN) mobilisation and transfer to plants has been scarcely studied. The proposal aims at laying out the scientific foundations of the use of this symbiotic fungi in the phytostabilisation/phytoremediation of uranium and radioceasium contaminated areas. Such scientific basement is a prerequisite to future development of technologies based on the use of the mycorhizosphere in the management of RN-contaminated sites. In other words, it is our objective to give a reply to the following question: do the mycorrhizal fungi represent a potential tool in the phytostabilisation/phytoremediationstrategy of RN-contaminated areas?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Coordination Action for Research in Cystic Fibrosis' in the context of a Sixth Framework call.

assistant: **Objectives**

Cystic Fibrosis (CF) is a life-shortening, genetic disease in Europe afflicting about 30,000 individuals in the European Union (EU). Mutations in a single gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) cause CF and a spectr um of related disorders. Despite impressive advances in understanding the disease, patient life expectancy and quality of life remain limited because resources are scattered in Europe. Thus, CF remains a serious medical issue for Europe. CF highlights the complex challenges of genetic diseases in the post-genomic era, pioneering explanations for pathological mechanisms and rational approaches to therapy. Because CF causes severe lung disease, the main respiratory diseases affecting EU-populations mig ht ultimately benefit from advancements in CF research. Moreover, CF is a model monogenic disorder for molecular medicine, with its complex pathogenesis serving as a paradigm for the study of important multifactorial diseases. Building on the success of the FP5-funded CF Thematic Network (www.cfnetwork.be), a three-year Coordination Action, EuroCareCF (European Coordination Action for Research in Cystic Fibrosis) will unite CF research in Europe. EuroCareCF will translate research results into optimise d clinical management and therapy development to promote good standards of care for European CF patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'pSafety Certification of Software-intensive Systems with Reusable Components' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The competitive edge of the European industry in the embedded systems domain is an enabler to achieve a leading position in the growing global market of safety-relevant embedded systems. The main success factors in this context will be the ability to understand the key reasons for the huge increase in cost and development time, and to adopt efficient methods and processes for development of these safety-relevant embedded systems. Also, increased requirements for certification from legislation, together with the perceived trend towards 'product-oriented' standards (from 'process-oriented' ones), demand fundamental paradigm shifts in the certification perspectives.pSafeCer is targeting increased efficiency and reduced time-to-market by composable safety certification of safety-relevant embedded systems. The industrial domains targeted are within automotive and construction equipment, avionics, and rail. pSafeCer will also develop certification guidelines and a training example for other domains, thus considerably increasing its market impact.A primary objective is to provide support for system safety arguments based on arguments and properties of system components as well as to provide support for generation of corresponding evidence in a similar compositional way. By providing support for efficient reuse of certification and stronger links between certification and development, component reuse will be facilitated, and by providing support for reuse across domains the amount of components available for reuse will increase dramatically. The resulting efficiency and reduced time to market will, together with increased quality and reduced risk, increase competitiveness and pave the way for a cross-domain market for software components qualified for certification.pSafeCer bri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'SmartSantander' (SmartSantander) targeting Seventh Framework.

assistant: **Abstract**

SmartSantander proposes a unique in the world city-scale experimental research facility in support of typical applications and services for a smart city. Tangible results are expected to greatly influence definition and specification of Future Internet architecture design from viewpoints of Internet of Things and Internet of Services.This unique experimental facility will be sufficiently large, open and flexible to enable horizontal and vertical federation with other experimental facilities and stimulates development of new applications by users of various types including experimental advanced research on IoT technologies and realistic assessment of users' acceptability tests.The facility will comprise of more than 20,000 sensors. It will utilise the results of two major EU-funded projects, SENSEI and WISEBED, in creating a secure and open platform of heterogeneous technologies.The city of Santander was chosen in response to offer of full support received from regional Government of Cantabria with real cash contribution of 500,000 €. Thereby strengthening their chance of winning the 2016 election of the city as the Cultural Capital of Europe.To efficiently achieve the goals of SmartSantander, three phases of deployments have been envisaged. It is also planned to issue two Open Calls for the experimental facility to be used by researchers from outside the project and involvement of various types of users to develop new applications.Such a unique facility with practical experience gained and feedbacks received, enables better understanding and insight into issues of: 1) Required  capacity, 2) Scalability, 3) Interoperability 4) Stimulation of faster development of new and innovative applications and 5) Influence specification of FI architecture design.The SmartSantander p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Monitoring systems to Assess Geotechnical Infrastructure subjected to Climatic hazards' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The aim of the project is to develop novel systems to monitor earth structures exposed to climate hazard.  Following completion of this research and concept demonstration project and subject to additional industry or commercial funding for the development of the technology, this effort is expected to eventually result in new commercial instruments and data management systems which it is in turn expected to lead to major improvement in design, maintenance, and adaptation of geotechnical infrastructure in a changing climate.The technological and scientific project will be implemented via secondments and recruitment of 182 researcher months in total including 72 months of recruitment and 110 months of secondment (51 months from Industry to Academia and 59 months from Academia to Industry).One of the major focus of the project will be the development and concept demonstration of two instruments for field measurement of pore-water tension (suction) up to 1.5 MPa, namely a high-capacity tensiometer for long-term measurement at shallow depths (<2m) and a tensiocone for rapid measurement of suction profile at great depths (up to 20m). Using proof-of-concepts prototypes developed by the academic partners in MAGIC, scientific and technological research will be carried out jointly by Industrial and Academic partners to use their respective scientific findings into a plan to assess the feasibility for the development of commercial instruments for pore-water tension measurement.MAGIC will also attempt to develop novel techniques for high-resolution imaging of water content based on Electrical Resistivity Tomography moving from proof-of-concepts prototypes already developed by academic partners. In addition, MAGIC will tackle the problem of real-time data control based on the concept
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Artificial molecular machines in membranes: transmembrane relays for ion transport, catalysis and cargo pumping' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

This program will develop artificial molecular machines confined within lipid bilayer membranes, to control transmembrane transport and catalysis in cellular systems. Molecular machines are ubiquitous in nature. At the heart of many biological processes are protein machines confined within biological membranes, which drive non-equilibrium transmembrane ion pumping via the consumption of chemical fuels. Biology has evolved to utilise the controlled nanomechanical motion of molecular machines to mediate numerous complex tasks in the cellular environment – a clear indication of the immense technological potential of synthetic systems that work in a comparable way. Despite this fundamental importance, synthetic molecular machines able to facilitate out-of-equilibrium pumping of ions have not been developed. To address this key challenge, this project seeks to develop synthetic analogues of biology’s membrane pumps: artificial molecular machinery that can interface and be manipulated within lipid bilayer membranes.Its objectives are to develop:•molecular machine ion transport relays, able to pass ions and catalysts across lipid membranes•stimuli-responsive mechanically-interlocked ion and molecular transport shuttles •molecular machine transmembrane pumps, capable of non-equilibrium active transportBesides crucial impact to the rapidly expanding, but to date surprisingly distinct fields of molecular machines and membrane supramolecular chemistry, the results from this project will enhance our understanding of non-equilibrium processes within and across lipid bilayer membranes. We anticipate that the systems developed over the course of the grant will provide the basis for the longer-term development of novel tools for applications in chemical and synthetic biology, such as t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Anticorruption Policies Revisited. Global Trends and European Responses to the Challenge of Corruption', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The central objective of ANTICORRP is to investigate and explain the factors that promote or hinder the development of effective anticorruption policies and impartial government institutions.  ANTICORRP directly addresses the objective in the Work Program by examining what the causes of corruption are, how corruption can be conceptualized,  measured and analysed, what the impact of corruption on societies is and how policy responses can be tailored as to deal effectively with this phenomenon. The starting point for this project is the following: The knowledge about the very negative impact that corruption has on a great number of factors that are important for human well-being (economic prosperity, population health, life satisfaction, gender equality, social trust, political legitimacy, etc.) is now well established. At the same time, knowledge about how corruption can be successfully fought by political means is much less developed. While this project concentrates on corruption in Europe, ANTICORRP also has a global scope. The project will identify general global trends concerning corruption and select ‘over-performing’ and ‘under-performing’ countries in terms of their progress towards less corrupt governance regimes and conduct more detailed qualitative analyses of these cases. The project includes participants from anthropology, criminology, economics, gender studies, history, legal studies, political science, public policy and administration and sociology  at twenty-one units in sixteen European countries. Research will be conduced using a various set of methods including historical case-studies, large-scale surveys and ethnographical approaches. The project will strive to ensure that the research findings are spread to policy makers and the general public by usin