RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'TWINNING for a Comprehensive Clinical Centre for the Diagnosis and Treatment of Parkinson's Disease' under Horizon 2020.

assistant: **Concept**

Unlike other EU member states, Luxembourg lacks a tradition for translation of fundamental research into clinical practice, which hampers health innovation and its adoption in cutting-edge medicine. During the last years, the Luxembourg Government made substantial efforts to position biomedicine as a key innovation driver. This highly successful biomedical initiative placed fundamental research on Parkinson’s disease (PD) in Luxembourg on an internationally competitive level, however, to realise the economic and health benefits for the population, closing the gap between basic science and clinical application is now a crucial challenge. CENTRE-PD aims at TWINNING the Universities of Oxford and Tübingen, two worldwide leading centres for PD, with the University of Luxembourg (UL) to establish a comprehensive clinical PD centre in Luxembourg. CENTRE-PD will build human and institutional capacity for an excellent centre for diagnosis and treatment of PD in Luxembourg on the one hand and will ensure sustainability and viability of the centre on the other hand. We expect to reach key deliverables in three areas: (i) building of new infrastructures at UL (including a prospective PD patient cohort and at-risk cohort, a brain bank, neuro-imaging and stem-cell platforms, a neuro-stimulation centre and gait laboratory), (ii) launching of joint research initiatives (harmonised clinical datasets and neuropathological validation, joint biomarker studies for early diagnosis and stratification of PD, compound screening campaings on patient-based cellular models, and joint studies on neuro-modulation), and (iii) engaging key stakeholders through clinical and public outreach programmes, training of clinical researchers and basic scientists, partnerships with industry and initiatives for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'International Congress on Nanotechnology and Research Infrastructures' (GENNESYS) under Seventh Framework.

assistant: **Objectives**

This Project builds on the GENNESYS European-wide study, which extensively analized the needs and opportunities for coordinating future research and development in nanomaterials science and technology. The mission of the International GENNESYS Congress on Nanotechnology and Research Infrastructures is to establish a strategic partnership between nanomaterials research laboratories, universities, industry and the European research infrastructures. A well coordinated nanomaterials science and technology program needs to be integrated into research infrastructures in the whole of Europe and in close regional, national and international collaboration to the welfare of the society and of the economy.The GENNESYS International Congress is focused on future visions and actions to achieve breakthroughs in nanomaterials science and technologies. At this prestigious conference various R&D&T roadmaps as worked out by worldwide experts as well as major conclusions and recommendations from the GENNESYS study will be presented to an international audience of major stakeholders in science, politics and industry, stimulating the development of European research policies.The congress will take place in Barcelona during the Spanish EU presidency, the Coordinator ICMAB (Institut de Ciència de Materials de Barcelona from CSIC) will work closely with its partners DESY (Deutsche Elektronen-Synchrotron), PRUAB (Parc de Recerca Universitat Autònoma de Barcelona) and INL (International Iberian Nanotechnology Laboratory), ensuring that the outcomes have the authority and support of leading organisations in this field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Looking for the Neural Basis of Human Consciousness through levels of awareness', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

In recent years there has been an explosion of scientific work on consciousness, in cognitive neuroscience, psychology, and other fields. Only a few research groups have addressed questions related to awareness on subjects in different states of consciousness such as sleep, sedation or comatose state. Several studies showed partially preserved cognitive functions in pathologies of consciousness but presently there is no validated objective consciousness meter that can be used as proof or disproof of awareness in severely brain-damaged patients.We will use EEG, fMRI and behavioural measures:a) To determine which cognitive processes in the intention to move domain can be reach by different levels of awareness;b) To characterize the neurocognitive signatures for the intention-to-action in different pathologies of consciousness.The applicant and the host institution provide complementary skills for this project. While the applicant has expertise in behavioural neurology and neurobiology, the host institution will provide the skills in neuroimaging, neurophysiology and cognitive psychology. In this respect both the applicant and the host institution will benefit from the fellowship.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'InfraStructure for the European Network for Earth System Modelling' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

IS-ENES will develop a Virtual Earth System Modelling Resource Centre (V.E.R.C.), integrating the European Earth system models (ESMs) and their hardware, software, and data environments. The overarching goal of this e-infrastructure is to further integrate the European climate modelling community, to help the definition of a common future strategy, to ease the development of full ESMs, to foster the execution and exploitation of high-end simulations, and to support the dissemination of model results and the interaction with the climate change impact community. The V.E.R.C. encompasses models, the tools to prepare, evaluate, run, store and exploit model simulations, the access to model results and to the European high-performance computing ecosystem – in particular the EU large infrastructures DEISA2 and PRACE. The V.E.R.C. developed by IS-ENES is based on generic ICT, Grid technology and subject-specific simulation codes and software environments. The European Network for Earth System Modelling (ENES) leads IS-ENES. This network gathers the European climate and Earth system modelling community working on understanding and prediction of future climate change. This community is strongly involved in the assessments of the Intergovernmental Panel on Climate Change and provides the predictions on which EU mitigation and adaptation policies are elaborated. IS-ENES combines expertise in Earth system modelling, in computational science, and in studies of climate change impacts. IS-ENES will provide a service on models and model results both to modelling groups and to the users of model results, especially the impact community. Joint research activities will improve the efficient use of high-performance computers, model evaluation tool sets, access to model results, and prototyp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Distributed Network of Active Noise Equalizers for Multi-User Sound Control' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The project is aimed at developing a novel wireless acoustic sensor network (WASN) for multi-user active noise equalization without the need of using headsets. This system is formed by multiple active noise equalizers (ANEs), which act as a node in a WASN-type set up and cooperate to simultaneously solve their node-specific noise equalization problems. By doing so, the proposed system can simultaneously ensure the auditory comfort of multiple users that are regularly exposed to high noise levels. This is radically different from the current multi-user systems for ANE where each node aims at ensuring the auditory comfort of each passenger without cooperation.To implement the proposed multi-user ANE, the project will rely on distributed algorithms derived within the EU-FET HANDiCAMS project. These algorithms build on node-specific cooperation rules to allow the cooperation of devices interested in different signal processing tasks and let them attain superior performance as compared to the case where they would operate on their own. In particular, through these node-specific cooperation rules, these algorithms yield a system that overcomes the two main limitations of the existing technologies. First, the spatial diversity of all the microphone signals can be leveraged and hence superior levels of noise attenuation can be attained in the active noise equalization problem of each node. Second, there is no performance degradation due to the acoustical interaction between ANEs of different users, which allows to perform simultaneous ANEs in scenarios with a high density of users.Due to its competitive advantages, the current levels of noise reduction can be attained with much simpler and cheaper ANEs, which will make the technology more accessible and will enhance the commerc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated Internet-Based Environment for Social Inclusion of Children with Autism Spectrum Conditions (ASC)' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Autism Spectrum Conditions (ASC, frequently defined as ASD - Autism Spectrum Disorders) are neurodevelopmental conditions, characterized by social communication difficulties and restricted and repetitive behaviour patterns. Current studies suggest 1% of the population might fit an ASC diagnosis. Alongside their difficulties individuals with ASC tend to have intact and sometimes superior abilities to comprehend and manipulate closed, rule-based, predictable systems, such as computerized environment. Their affinity for the computerized environment has led to several attempts to teach emotion recognition and expression, and social problem solving to individuals with ASC, using computer-based training.<br/>In the last decade, web applications have been increasingly used for social interaction, forming online communities and social networks. Anecdotal reports of the emergence of online autistic communities, and the use of forums and virtual-worlds, show the great promise the internet holds for better inclusion and social skills training for users/people with ASC. Since intervention into ASC has been shown to be more effective when provided early in life, using the internet as a platform for the support of younger individuals with ASC could significantly promote their social inclusion.<br/>The proposed project aims to create and evaluate the effectiveness of such an internet-based platform, directed for children with ASC (and other groups like ADHD and socially-neglected children) and those interested in their inclusion. This platform will combine several state-of-the art technologies in one comprehensive virtual world, including analysis of users' gestures, facial and vocal expressions using standard microphone and webcam, training through games, text communication with peer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multiscale-Multiphysics Modelling of Ti alloy medical implants based on Additive Manufacturing technology' to be submitted under Horizon Europe.

assistant: **Abstract**

Patient-customized bone replacement implants with (micro)structural and mechanical properties tuned by design would constitute a major advance in the biomedical field. Classical metallurgical post-processing (e.g. annealing or hot-isostatic-pressing) offer an efficient way to modify metallic alloys microstructure and resulting properties. Hence, the combination of titanium alloys, scaffold structures, and additive manufacturing open promising avenues to produce custom implants that mimic natural bones and thus reduce the need for revision surgery. Moreover, modelling tools across scales are mature enough to simulate microstructural evolution and its effect on material properties, which could accelerate the design of high-quality, high-fidelity, affordable implants. The aim of M3TiAM project is to develop robust computational tools to predict the effect of post-processing treatments on microstructure and mechanical properties of additively manufactured scaffolds structures, in order to guide the design of novel Ti-based implants. To do so, multidisciplinary and multiscale theories will be combined into i) a process-sensitive structural module using phase-field modelling to predict phase evolution of biocompatible Ti alloys and ii) a structure-scaffold geometry-sensitive mechanical performance module using crystal-plasticity (microscale) and finite element (macroscale) models to predict the mechanical behaviour of bulk material and scaffold structures. The resulting computational framework will guide the design and optimisation of novel metallic implants, from the level of their microstructure to that of entire scaffold-based implants. The expected impact include: new insight into process-microstructure-properties in metallic alloys, new multi-scale and multi-physics coup
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Biochemical and functional studies of lineage-specific transcription factor complexes in glioblastoma-derived stem cells' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Cancer is one of the leading causes of death worldwide. Brain cancers, in particular glioblastoma (GBM), have incredibly poor prognosis and there are currently few effective treatments. Our understanding of the molecular defects associated with cancer has significantly increased over the past decade. Many of the commonly disrupted genes control cell proliferation and survival pathways. However, it is increasingly clear that genetic changes operate in a tissue-specific and developmental context and cancer can be viewed as a disease of aberrant cell differentiation. For some cancers, including GBM, cells with stem cell characteristics may initiate and/or sustain tumour growth. Therefore, knowledge and methods from developmental biology and stem cell biology are likely to provide new insights into the biology of this disease and lead to new therapeutic strategies.I will focus on a set of lineage-specific transcription factors with known expression within neural stem and progenitor cells, both in vitro and in vivo. My goal is to dissect their role in self-renewal and differentiation and how this is related to the cell cycle machinery and “classic” cancer pathways. How cell differentiation and cell proliferation programs operate in stem and progenitor cells is a fundamental question for both basic biology and cancer research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nanobody-Targeted  Camk2d Inhibition for Cardiac Arrhythmias' (Nab-Heart).

assistant: **Innovation**

In cardiac cells, kinase enzymes are key modulators of calcium homeostasis, mitochondrial function, excitation-contraction coupling, and metabolism. Of these, the delta isoform of Ca 2+ /Calmodulin-dependent kinase (Camk2d) is particularly relevant to the induction of life-threatening cardiac arrhythmias.Of the several promising small molecule and peptide Camk2d inhibitors proposed in pre-clinical investigations, none has entered clinical applications. The severity of side effects, a well-known issue for kinase inhibitors, in this case is further amplified by the high homology and the unique Ca 2+ -dependent regulatory physiology among four Camk2 isoforms, plusthe delicate role of the ubiquitously expressed Camk2d in non-cardiac tissues. Since the major obstacle to developing a cardio-specific, Camk2d-specific inhibitor mainly relies on reaching high isoform selectivity, the Nab-Heart project will conjugate selected Nanobodies (Nbs) to a new Camk2 inhibitory peptide to develop the first selective kinase inhibitor. Such a molecule will prevent the development of life-threatening arrhythmias in a variety of cardiac conditions, spanning from inherited arrhythmias such as Long QT Syndrome toacquired and highly prevalent diseases such as atrial fibrillation and heart failure. The team will identify Nb candidates with the desired Camk2d isoform-selectivity and affinity. Optimized substrate-mimicking Camk2d-inhibitory peptides will be covalently linked to the selected Nbs (Nb-inibs) to ensure delivery of the inhibitory module to the pathologically active Camk2d target with outstanding selectivity and affinity. The strategy will be validated in vivo through cardio-specific AAV9 delivery of the Nb-inib candidates in a mouse model of Catecholaminergic Polymorphic Ventricular Tach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Neuronal Information through Neuronal Interactions' (NINI), addressing dissemination and exploitation.

assistant: **Impact**

Our thoughts and actions result from the activity of functionally specialized neurons in the brain. We have learned a lot about how individual neurons encode sensory, cognitive and motor information. But we lack understanding of how this information comes about. The fundamental, yet rarely addresses, assumption is that this information results from neuronal interactions within local and large-scale brain networks. However, little is known about which specific interactions establish information coding. This is because neuronal interactions and information coding are largely studied in isolation in separate research fields. The key objective of this proposal is to close this gap, and to directly test which neuronal interactions establish information coding. We will employ a novel interdisciplinary approach that tightly integrates human and monkey electrophysiology and that combines several key advances established in our lab. First, we will perform directly comparable human M/EEG and monkey EEG recordings during the same decision-making task. We will employ a common analysis platform to identify local and large-scale interactions underlying information coding in both species. Second, we will characterize the circuit interactions underlying information predictive interactions in monkeys using simultaneous large-scale multi-area microelectrode and EEG recordings in the same behavioral task. We will combine these recordings with manipulative techniques to causally probe the circuit interactions underlying information coding.If successful, this work will constitute a paradigm shift in cognitive neuroscience by linking to largely disconnected fields: neuronal interactions and information coding. Identifying neuronal interactions that underlie neuronal information coding will e