RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a late-onset-Alzheimer’s disease (LOAD) profile for accurate diagnosis and identification of potential therapeutic approaches' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Late-onset Alzheimer’s disease (LOAD) is a neurodegenerative disorder that currently affects 2% of the population in industrialized countries; the risk of LOAD increases in individuals beyond the age of 70 and it is predicted that the incidence of LOAD will increase 4-fold within the next 50 years which may cause a great socioeconomic problem. Early diagnosis and evidence-based interventions that improve the condition of LOAD patients are not available. Numerous studies revealed that LOAD is an age-related multifactorial disease, which is evident on the protein level in hardly accessible cerebrospinal fluid by decreased beta amyloid and increased hyperphosphorylated tau protein.The Medical University of Vienna and the diagnostics company Randox have already characterised LOAD related proteins in blood platelets that reflect features of neurons. These proteins indicate multifactorial interactions in LOAD leading to our holistic approach. The present project, unlike others, will simultaneously determine (epi)genetic, protein-specific, and metabolic parameters of LOAD patients.On the genetic level LOAD is associated with Apolipoprotein E4 polymorphism. Decreased vitamin B12 and folate and increased homocysteine levels are metabolic dysfunctions that may be linked to epigenetic changes in methylation patterns of LOAD relevant genes.The University of Vienna will identify metabolic LOAD markers in blood. The MUW will perform complementary (epi)genetic and proteomic studies, and will generate algorithms for multi-arrays. Significant (epi)genetic aberrations in LOAD will be translated into assays of a DNA Chip at Randox. In addition, the SME Ledo and the Polish University Politechnika Lodzka join their expertise to develop a standardised ready-to-use platelet isolation column f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Investigation of auditory plasticity using MEG and f MRI'.

assistant: **Innovation**

I am a French researcher working in Lyon. My recent research focuses on the perceptual correlates of injury-induced plasticity in the auditory centres of human subjects with cochlear damage.My interests expand to all aspects of sensory impairment/ learning disorders and auditory plasticity induced by auditory deprivation, with a focus on identification of parameters influencing auditory pathway plasticity. My research mainly used psychoacoustic measurements, and I now plan to investigate auditory plasticity further, using brain-imaging techniques such as MEG.The Lyon University Hospital will be equipped in 2005 with a MEG device (combined with EEG), which will give me the opportunity to develop MEG experiments with the above topics in view. I would like to spend 1-year research beginning next fall at the Brain Imaging and Modeling section, NIDCD, IH, Bethesda.During my stay, I would like to apply large-scale computational modeling to in vivo human functional imaging data from MEG-EEG and fMRI. This would allow me to pursue brain imaging and neural modeling experiments in my return institution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'An avian model for understanding and preventing the negative effects of poor developmental conditions on subsequent health state, fertility and ageing rate'.

assistant: **Objectives**

Poor developmental conditions have been shown to impact subsequent health, fertility and lifespan, both in human and animal models. However, the molecular, developmental and physiological mechanisms underlying these adverse  effects on health later in life are still poorly understood. Since mammalian models do not allow manipulations of embryo development independently of maternal influence and nutritional state (i.e. without the mother potentially compensating for any manipulation), I will pioneer a new avian model using experimental controls of embryo growth and development through modulation of incubation temperature.The key goals of this postdoctoral project are:(i)To determine the extent to which developmental conditions (i.e. slow vs. fast embryo growth rate, developmental instability) induce deleterious effects on health, fertility and rate of ageing in later life.(ii)To identify the molecular and/or physiological mediators of such adverse effects, by targeting parameters related to the ageing process (mitochondrial functioning, oxidative stress, telomere erosion and cellular stress resistance) and investigating the ‘sparing of vital organs’ hypothesis.(iii)To test both pre- and post-natal antioxidant therapies as preventive strategies to limit the deleterious impact of poor growth conditions on subsequent health, fertility and rate of ageing.This project will use a novel approach to reveal completely new insights into the importance of developmental conditions for subsequent life-history trajectories and rates of ageing. It will also provide important insights for the poultry industry about the impact of developmental conditions and in ovo antioxidant supplementation on subsequent productivity and fertility.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The Brainstem-Hippocampus Network Uncovered: Dynamics, Reactivation and Memory Consolidation'.

assistant: **Concept**

Storing information and then using it to guide behaviour is one of the most remarkable abilities of the brain. Memory storage relies on network mechanisms in which the hippocampal formation interacts with the rest of the brain during periods of sleep. The neural computations associated with this process correlate with both enduring and transient changes in the excitability of neural circuits. Nuclei located in the brainstem dictate these ‘state changes’, modulating the signalling between groups of forebrain cells. However, the role of the brainstem in memory formation remains unknown. This project aims to determine the role of different sleep stages in memory formation and long-term consolidation, and to elucidate the functional role of the brainstem in these processes. To this end, I will use a battery of experimental techniques, mathematical methods and biophysical models to probe and analyse the neural activity of the brainstem-hippocampal system. Neuronal activity will be recorded concurrently from the pons, thalamus and hippocampus of mice while performing a reference memory task. I will identify specific neural mechanisms that trigger different hippocampal synchrony regimes and memory reactivations mediated by brainstem activity during wakefulness and sleep. For this, I will develop state-of-the-art methods based on signal processing and machine learning. Besides, using optogenetic tools, I will determine the causal role of the brainstem in regulating hippocampal circuits and the animals’ behavioural performance. Finally, I will develop a biophysical model to test how well different network mechanisms explain the dynamics of the interactions between the brainstem and the hippocampus. Understanding the detailed properties of the interactions between these systems o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Stratospheric Ozone Loss from Volcanic Eruptions' (SOLVE) targeting Horizon 2020.

assistant: **Abstract**

The stratospheric ozone layer absorbs harmful UV irradiation, protecting life on Earth. Only small changes are needed for significant damage to human health and agriculture, making it essential to understand the chemistry behind ozone depletion. Most of the ozone depletion has been caused by man-made emissions of the CFCs and halons, which are now banned through the Montreal Protocol and its amendments. However, due to the long-lived nature of these species, full recovery of the ozone layer is still decades away. In a changing climate, stratospheric composition, temperature and dynamics may be significantly altered, changing the catalytic ozone depletion in the future. Furthermore, new concerns regarding the ozone layer have emerged, with explosive volcanic eruptions possibly causing the largest perturbation to the ozone layer in the future. In this project, I will use different methods to determine the impact of halogen injections into the stratosphere on the ozone layer, determining the kinetics of bromine-containing species using laboratory and quantum chemical methods and incorporating them into a global chemistry and climate model. The first two years, I will be at Harvard, where I will use different atmospheric models to investigate the stratospheric impact of volcanic eruptions for a variety of future climate scenarios. I will also be carrying out experiments using cavity enhanced absorption spectroscopy to determine the kinetics of an atmospheric reservoir species for reactive bromine in the atmosphere. In the last year of the project I will be at University of Copenhagen and carry out experiments with a cold matrix setup with Fourier transform infrared spectroscopy to investigate the reaction. Throughout the project, I will determine the mechanisms of halogen r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Digitalised Value Management for Unlocking the potential of the Circular Manufacturing Systems with integrated digital solutions' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The aim of the current project is to bring about the development of the full demonstrator of DiCiM, a set of integrated digital solutions that makes use of Internet of Things (IoT), Machine Learning (ML) based Artificial Intelligence (AI), Big Data, Image Processing and Augmented Reality (AR) to support different actors of the industrial value chain such as managers, engineers and operators in their decision making and to carry out value recovery activities for circular economy. The integrated digital solutions include an open access digital platform for lifecycle information management and support solutions for value recovery activities.DiCiM project revolves around the value use and value recovery phases of the Circular Value Model (CVM) with the specific data, technology and the management needed to support its implementation. In particular, it focuses on integrated digital solutions to enabling condition monitoring during the use phase, optimizing the reverse logistics, and achieving efficiency and responsiveness in the value recovery activities (i.e. collection, inspection, sorting, disassembly, testing and repairing/refurbishing/remanufacturing/recycling) to enable reuse of products, parts and materials.DiCiM project will demonstrate integrated digital solutions in four use cases in three industrial sectors that represent over two thirds of the European Economy. They include whitegoods (i.e. refrigerators, washing machines), electronics (i.e. printers) and automotive. With important gains such as increase in spare part recovery efficiency by 90% (which means 126 000 labour hours are saved for refrigerator demonstrator) and increase in spare part recovery rate by 20% (about 2920 tons net material saving for washing machines and 6000 tons for automotive).DiCiM digit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Textile Studies: questions and issues between knowledge and knowhow'.

assistant: **Objectives**

This research project explores the modern reconstruction processes of archaeological textiles and focuses on the intersection between Natural Sciences, Humanities, experimental methods and technical skilled practices. Taking an anthropological and an ethnographic approach, the project aims to highlight the topical concepts of “knowledge” and “know-how” as specific as well as complementary knowing processes and contributes to define the interdisciplinarity at work in the field of Textile Studies. The mobilization of several disciplines and methods  leads to the establishment of a hybrid field of study that can be understood by taking into consideration the practices of knowledge, more than knowledge itself. How do the different methods at work, the specific research reference systems in the disciplines involved, and the knowing practices generated in the study of ancient archaeological textiles contribute to defining their objects and to creating a research field that is both unified and composite? How are the theoretical tools and technical skills available to the “experts” in all areas of Textile Studies coordinated and interconnected? Where and how is it possible to grasp their interaction, and ultimately to question it, first in its specificity and then within its broader epistemological implications? The ethnographic inquiry with the textile experts of the Danish National Research Foundation’s Center for Textile Research CTR (University of Copenhagen and National Museum of Denmark) and on their research programs will provide a description of Textile Studies ""in the making"". The objectives of this project are on four main axes: 1) Textile Studies, 2) Science and Technology Studies, 3) History and Anthropology of Knowledge, 4) Theoretical and Experimental Archaeolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Unraveling the peroxisome-associated mechanisms counteracting ferroptosis during quiescence' (PEROXISCENCE) under Horizon Europe.

assistant: **Objectives**

Quiescence, a temporary cellular state of non-proliferation, is widespread in nature. Quiescent fungi often cause persistent infections resistant to conventional treatments. Quiescence is maintained via the consorted action of several regulatory pathways. In yeast, these include stabilization of the eisosome-localized, ubiquinol-generating Flavodoxin-like proteins (FLPs), recently shown by my host labs to counteract ferroptosis, a form of iron-dependent cell death promoted by peroxidised phospholipid (PL) accumulation at the plasma membrane. Importantly, new results suggest that lack of eisosomes or FLPs disrupts peroxisome biogenesis and function, i.e. fatty acid β-oxidation. PEROXISCENCE focuses on the data-driven hypothesis that increased PL peroxidation rewires certain Membrane Contact Sites (MCSs), leading to channeling of fatty acids towards PL remodeling instead of β-oxidation, to compensate for defective repair. I will investigate this model by employing a multidisciplinary approach, including genetics, a split-Venus-based screening of peroxisomal MCSs, lipidomics and a secondment for training in STED microscopy, with the goals to 1) identify the enzymes involved in PL remodeling and determine their role in counteracting ferroptosis, 2) determine if eisosomes and PL peroxidation regulate fatty acid flux by affecting MCSs, and 3) elucidate the role of Pex11, a protein implicated in the formation of tethers at peroxisomal MCSs. The outputs of PEROXISCENCE are expected to provide novel scientific knowledge with an impact on the fields of cell biology, ferroptosis, aging, and fungal pathogenicity. Furthermore, understanding the mechanisms of lipid homeostasis in quiescence could lead to the identification of innovative ways to tackle persistent fungal infections. Wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrated Modular Plant and Containerised Tools for Selective, Low-impact Mining of Small High-grade Deposits' (IMPaCT) targeting Horizon 2020.

assistant: **Abstract**

The current mining paradigm promotes extraction from large ‘world-class’ deposits that have required innovations in mining techniques to deal with low grades, large infrastructure to deal with high throughputs and large feasibility studies to prove long-term commercial viability. High investment in operations is no longer available in the current economic climate and many small companies have ceased to trade, concentrating production and limiting the ability of the raw materials market to respond to increased demand for raw materials or shortages in raw material supply. The problem is most extreme for critical raw materials that are produced in small quantities relative to traditional metal commodities because the potential return on investment is too low. The IMPaCT project proposes a solution that develops a new switch on-switch off (SOSO) mining paradigm to improve the viability of many critical metal and other small complex deposits. The whole systems approach that we have adopted to realise the SOSO mining paradigm centres around technological innovations in mining equipment design and mine planning that would reduce the feasibility studies required, throughput of extracted material, infrastructure, land use, resource consumption and waste. Successful business models for SOSO mining require that mining and processing technologies can be adapted to multiple deposits and commodities. Risks that are associated with the approach concern geological uncertainty, metallurgical variability and social acceptance. The work programme aims to develop the proof-of-concept of total and sustainable mining and processing solutions using case studies in the West Balkans, and subsequently to examine the step-changes that would be required for the technology to be applied globally. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The impact of invasive grass species on the structure, function andsustainable use of coastal & inland sand dune ecosystems in Southern Africa' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The main objectives are defined as follows :* To investigate the current, and likely future, impact of A. arenaria on the dune systems of South Africa by studying the natural behaviour of the introduced sand stabilising dune grass.* To compare the effect of soil-borne pathogens and arbuscular mycorrhizal fungi on vegetation succession in temperate European sand dunes with coastal and inland sand dunes in Southern Africa and to examine the genetic structure of the invasive plant species.* To provide management prescriptions for the wise use and, if appropriate, control of A. arenaria to maximise its beneficial properties for coast protection without a concomitant threat to ecosystem function, biodiversity and wildlife.* To provide management procedures for the wise use and, if appropriate, control of the naturally invading tropical weed grass Cenchrus biflorus to maximise its beneficial properties for re-establishment of vegetation in over-exploited areas of Kalahari sand dune savannah.Expected OutcomeThis project should provide recommendations to use species for coastal dune management in South Africa which can be controlled or else blend in with the natural landscape. It should also provide recommendations to manage the Kalahari savannah ecosystem, especially around artificial watering points, without a concomitant threat to ecosystem function, biodiversity and wildlife. In addition, it should provide knowledge on the role of soil organisms and genetic variation in the invasiveness of plant species.The key activities involve :* Life history of A. arenaria and its effect on the coastal dune ecosystem : In the field, flowering characteristics and seed set, seed viability, dispersal, and germination success rate will be determined, as well as seed establishment as compare