RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Fully automated, controlled and versatile system for low cost, high rate and energy efficient production of highly loaded aeronautical structural parts' (Falcon).

assistant: **Concept**

The main objective of the FALCON project is the design and manufacturing a versatile  tooling system (reduction of tooling by up 40%) for the effective (30% reduction in time, 20% in cost and 20% in energy) and high quality (Aeronautic Quality Standards) production of CFRP frames for different fuselage sections subjected to different level of loads. The FALCON system will include two interrelated components (press-forming tooling and curing tooling) which will be supported through laser tracker technologies and robotic positioning/placement equipment.The press-forming tooling consists of flexible and adaptable modules designed for different frame geometries that will increase the number and typologies of produced parts. These modules have plug and produce connectors for fast and accurate connexion and individual hydraulic cylinders for a precise controlling of the kinematics of the process. In addition, the cooling/heating system will be also especially designed for improving part quality and process energy efficiency. This cooling/heating is adapted to part geometries through the combination of metallisation technologies with embedded channels and metallic additive 3D technologies applied to trickiest geometries.In other hand, the curing tooling is designed for including all the required reinforcements into the frame during the curing process independently to the face of the part in which should be placed. This will be achieved by means of positioning tooling which are produced according to each part requirements through the utilisation of high accuracy mechanising equipment.Finally, the process is continuously controlled and optimised thanks to a real time monitoring system in order to be robust and repeatable. The monitoring system is feed through integrated sensors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DYNAMICE: An integrated framework for biomechanical phenotyping of arteries to disentangle mechanical causes of arterial stiffening in diabetes' under Horizon 2020.

assistant: **Concept**

Accelerated arterial stiffening, an important complication in diabetes, increases cardiac workload eventually leading to heart failure. The arterial wall —consisting of elastin, collagen, smooth muscle, and glycosaminoglycans— may stiffen in diabetes due to 1) advanced glycation end-product (AGE)-induced collagen cross-linking, 2) calcification, or 3) changed glycosaminoglycan composition. The exact mechanical stiffening effects of these processes are unknown. Current preclinical, state-of-the-art measurement methods characterise arterial wall mechanics under static conditions. However, AGE-induced and glycosaminoglycan-associated wall stiffening may particularly affect dynamic characteristics (viscoelasticity) — especially relevant in vivo where arteries are subject to pulsatile blood pressure. The novel set-up for mechanical characterisation under such dynamic conditions I have previously developed still requires a matching computer modelling framework to correctly interpret the multidimensional, dynamic measurement data. I aim to 1) develop this modelling framework and 2) use it to quantify the characteristics of diabetes-associated stiffening processes by studying murine arteries with increased calcification, collagen cross-linking, glycosaminoglycan content, and combinations thereof. The forthcoming measurement platform —already sparking interest among international collaborators— enables realistic preclinical biomechanical arterial characterisation and will be the integrative keystone in my multidisciplinary research career. Its application to diabetes-associated arterial stiffening may yield breakthrough target and focus to further treatment of patients. Furthermore, its accessibility to (inter)national collaborators will be ensured by its implementation at the i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A novel lipoamino acid based system for peptide delivery: application for administering TT-232, a new tumor-selective somatostatin analog' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Foreseen ResultsIn order to engineer efficient drugs, it is very important to know the precise mode of action of the active compound. It is therefore of crucial importance to find out what signal transduction pathway(s) it interferes with, and furthermore to localise its target molecules. This is most wanted information as it will lead to improvement of the specificity of the drug and the elimination of unwanted side effects.The overall aim of the proposed research is the development of specific anti-proliferating drugs which can be easily administered for therapeutic use as anti-cancer agents. As lead compound will be taken: the somatostatin analog TT-232 does not exhibit endocrine effects, it does not inhibit the release of growth hormone, and is not toxic at doses as high as 120 mg/kg body weight. The peptide has been shown to interfere with intracellular tyrosine phosphorylation events, so that is clearly involved in the attenuation of growth factor signalling pathways. A major practical problem in the development of a useful peptide-compound is not only the selectivity of the anti-cancer drug for cancer cells, but also the efficient delivery of the active peptide to the tumor: peptides are often poorly absorbed and easily degraded, so that oral administration for instance is very difficult. Therefore, TT-232 will be tailored for oral administration by its conjugation to lipoamino acids, and its mode of action will be investigated by a detailed study of its interference with known growth factor dependent mitogenic signalling pathways. The intracellular target of TT-232 related products and their lipoamino acid conjugates. Analogous more potent compounds with similar function will be developed and customised for specific purposes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'IONEX AIR IONIZER FOR INSTALLATION IN VEHICLES' CABINS TO IMPROVE ROAD SAFETY FOR EU CITIZENS' under Horizon 2020.

assistant: **Concept**

IONEX Ltd, specialized in air ionization technology, has recently developed and tested a working prototype of a new solution, the most efficient and innovative IONEX air ionizer for installation in a vehicle’s cabin, which adds into the air sufficient number of negative ions for normalization of conditions inside a car. The key is in uniquely designed and patented carbon brush, which emits large amounts of negative ions without generating harmful ozone, and cleans the air of carcinogenic particles.We aim to finalize and commercially deploy our solution in the EU and worldwide during Ph.2&3, to create over 100 new employments and revenues reaching €45M by 2022. We have already attracted potential business partners in car industry (BMW) and air treatment industry (=HVAC) for further development of product (see their Letter of Interest). The innovation is significant, because it improves the indoor air conditions in all types of vehicles by integrating air ionization, which results in a calmer, more focused and cautious driver (by some studies, concentration can be improved by 30%), thus increasing safety (fewer accidents), protects health and lowers governmental health treatment expenses.Why are we the best for the job? We have been a SME manufacturer of different types of air ionizers since 1998 and have successfully marketed our ionizers to many EU and other countries (Belgium, Germany, Poland, Italy, Denmark, UK, Norway, UAE), gained rich IP portfolio (3 patents, 2 designs and 1 European trademark; most important patent is for carbon brush), and achieved an Innovation award for proposed solution. In 2016, the innovator and the owner of IONEX company, Lorena Leonardos, has shared her expertise and a collection of scientific studies in her book »Negative ions as a method
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European Partnership One Health AntiMicrobial Resistance' under Horizon Europe.

assistant: **Concept**

Antimicrobial resistance (AMR) is a global health challenge with an estimated 67% increase in global deaths attributable to AMR by 2050. The European Partnership One Health AMR (EUP OHAMR) is aiming to reduce the burden of AMR with an integrated One Health (OH) approach, recognising that human, animal and plant health are interdependent and interlinked with the environment. The partnership will boost AMR research and innovation (R&I) addressing the current knowledge gaps with the aim to improve surveillance of resistant pathogens and provide better diagnostics and more effective treatments of drug-resistant infections. It will support implementation research on prevention measures reducing the use of antimicrobials and spread of AMR and launch an ambitious work programme of joint activities to coordinate R&I investments, facilitate the use and re-use of R&I data, strengthen AMR R&I capacities and facilitate both knowledge translation and uptake of research results and innovations by industry, society, and policy makers.The EUP OHAMR builds on the long-standing collaboration of the partners from the Joint Programme Initiative on AMR (JPIAMR) but with a bigger ambition and a broader scope. The partnership consists of 53 partners from 30 countries from the European Union (EU) and beyond. With active engagement of key stakeholders across the AMR landscape, the partnership will strengthen European and global synergies through alignment of research priorities, policies, and investments. Furthermore, EUP OHAMR will support multisectoral and multidisciplinary collaborations to break the existing silos in AMR research. It will result in increased knowledge and solutions and provide an evidence base for uptake into policy and practice to prevent and tackle AMR. Thus, the EUP OHAM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The travelling astronomers. International collaborations after World War II and the reorganization of European astronomy (1953-1985)'.

assistant: **Objectives**

This research project investigates the history of astronomy in Europe after World War II. In the period between 1953 and 1985, a number of international collaborations were undertaken by several European countries, with the aim of strengthening astronomical research in terms of its capacity and facilities. These collaborations culminated in the construction of powerful observational facilities and the implementation of programmes for cooperation in professional research. In this respect, the initiatives taken from 1953 to 1985 inaugurated a new era of European astronomy. Indeed, in this period research facilities were made available in both hemispheres, new research networks were created, and there was a new attitude towards scientific cooperation.This study will analyse crucial aspects of the development of astronomy in post-war Europe. More specifically, this research will address the interactions among astronomers, scientific institutions, and governments in the light of the quest of new astronomical sites; the connections between scientific, technical, political, and economic issues in the foundation of new astronomical observatories; and the changes in the community of professional astronomers, both in terms of  research practice and social organization. Consequently, this study will contribute to elucidate the reorganization of astronomy in post-war Europe. Moreover, it will reinforce the comprehension of the development of scientific research, science policy and international scientific cooperation.


**Keywords:** history of astronomy,  astronomical observatories,  science in post-war Europe,  science policy,  international cooperation,  cold war science
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Avant Garde Approaches to Processable multiscale conjugated polymer hybrid materials with enhanced Electronic properties and water-repellency' (AGAPE), addressing dissemination and exploitation.

assistant: **Impact**

This project aims to circumvent the most severe flaws of Conjugated Polymers (CPs hereafter), namely their processability and stability, while not compromising or even improving their electronic performance. Approaches are presented that will produce performing, water-repellent and processable CPs to feed the emergent Hydrophobic Electronics. A procedure will be developed to allow the CPs grafting on OH-containing nanoparticles profiting of the applicant’s knowledge on NHC catalysts, acquired along his 2-year stage at Prof. Navarro’s Laboratory in the USA. Nanoparticles are selected to fulfill the double purpose of i) making the solution/suspensions of CPs thixotropic, thus easing processability, and ii) making the final material’s surface rough and so water-repellent. These hybrids will be incorporated into a third component (a polymer, solvent or CPs solution) to produce multiscale water repellent CPs, by taking advantage of the Host Group on surface modification, polymer compounding and superhydrophobicity. This project lies at the interfaces of Polymer Chemistry, Catalysis and Surface Chemistry on one hand, and requires the joint collaboration of Engineering, Chemical Physics and Pure Organic Chemistry. The rare combination of the Applicant’s and Host Group’s expertise allows to reasonably expecting the successful design of novel materials with exciting new properties
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Storage of Electrons into Chemical Bonds: Towards Molecular Solar Electrical Batteries' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

While photovoltaics has observed rapid growth in the last decades and utilization of solar energy becomes ever growing part of the total electricity produced by mankind, the lack of control over electrical output caused by fluctuation of solar irradiance is an inevitable drawback of the mass use of solar cells. Solar batteries, addressing intermittent production of solar energy, offer an elegant solution without the need of electricity transport and redistribution. In most examples solar cells are combined with rechargeable batteries (e. g. Li-ion, Pb) which increases the total weight and cost and leads to electricity losses. The approaches for molecular-based storage of light energy, solar thermal batteries, exploit photoswitching molecules (solar fuels) that generate heat upon thermal back isomerization. To this date, no molecular approach for solar energy storage and subsequent direct generation of electric current exists because this requires development of light-activatable molecules capable of hysteric electron storage and release. SOLBATT develops molecular systems for transformation of light energy into chemical bonds and their subsequent transformation to electric current. It uses fully organic redox-driven molecular switches that reversibly form an electron storing bond upon redox process and combines them with suitable redox-active partners that facilitate photoinduced electron transfer. SOLBATT (1) improves our understanding of electron storage into chemical bonds and their subsequent release, (2) delivers redox-responsive molecular systems that can be charged or discharged upon external stimulus, and (3) established design principles for photoactive redox materials suitable for the use in organic solar cells. Ultimately, SOLBATT takes the vital step in find
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovative bioinspired strategies towards selective lanthanide complexation and separation: From bacterial chelators to applications.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Lanthanides (Ln) are critical raw materials and designated with a high supply risk by the European Commission. Their mining and purification have a considerable negative environmental impact and we urgently need sustainable and efficient recycling strategies for these elements. It was recently discovered that many bacteria use Ln for growth and utilize them in the active sites of enzymes. In addition, a Ln-binding protein with unprecedented affinities for Ln (Lanmodulin, LanM) has been isolated from one of these bacteria. The Ln-uptake mechanisms of these bacteria remain vastly underexplored, however, the involvement of polydentate ligands (chelators) to bind lanthanides — lanthanophores (lanthanide carriers) — has recently been established. For the first time, practical applications of chelators that were specifically designed by nature to bind, recycle and separate the technologically-indispensable lanthanides are in reach. Thus, the objective of LANTHANOPHOR is the identification and isolation of lanthanophores from the spent media of lanthanide-utilizing bacteria and the synthesis of short peptides based on the Ln-binding moiety in LanM. A comprehensive characterization of the lanthanophore including their lanthanide coordination chemistry, will contribute to our understanding how Ln are made bioavailable inside bacterial cells. The lanthanophore and the peptides will be evaluated for the use in Ln separation and recycling. I will further elucidate whether these ligands can be used in lanthanide bioremediation or for medical applications as chelators. The results of LANTHANOPHOR will advance the development of sustainable solutions and bioinspired applications that are urgently needed in the quest for new, environmentally friendly and faster Ln separation and recycl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Agriculture under extreme environmental conditions in latin america by using osmoprotection genes to generate stress-resistant potato and bean plants', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The primary goal of the project is the recovery of arid and semi-arid soils in Latin America by their cultivation with plants metabolically engineered to resist biotic stresses such as drought, salinity, cold or freezing conditions. Two food crops, potato and beans, which are not natural resistant to such stresses, will be genetically manipulated by the introduction of genes responsible for the synthesis of compatible solutes. This will involve the use of already characterize deukaryotic and prokaryotic genes and the isolation and characterization of new genes for the synthesis of these osmoprotective compounds. In addition, the improvement of soil fertility will be approached by the establishment of a more efficient nitrogen fixation by bean root nodules under osmotic stress. This is intended to be achieved by the symbiotic combination of stress-resistant beans and host-specific Rhizobium strains.