RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Integrated business information systems' to be submitted under Fourth Framework.

assistant: **Abstract**

The environment of enterprises is changing in terms of changing markets products and technology. One of the reactions is transformation of hierarchical organisations into flat hierarchies and lean organisations into interrelated, distributed, autonomous units. This brings higher complexity and interdependency for co-operative business processes. Time becomes a key factor in seeking competitive advance. The periods for decision making are reduced and hence sustaining leadership in the market becomes even more difficult. Therefore decisions are often made on incomplete, uncertain and conflicting information. Today's information systems can't support the wide variety of people performing distributed business processes efficiently or reliably as long as they can't manage incomplete and uncertain information.To improve the competitiveness of European Industry, the objective of IBIS is to develop a new, highly innovative tool allowing for a higher degree of automation and integration as well as redesigning of business processes, including the management of incomplete information.To increase the degree of automation and the flexibility of business processes simultaneously, it is necessary to have an explicit representation of the semantics of the exchanged information and the capability to automate its processing. Since quantitative information plays an important role in all major business processes, the project focuses on quantitative and related information. The related tool has the capability to store, retrieve and process quantitative data, i.e. numerical data associated with a meaning, despite the fact that they might be incomplete, uncertain and conflicting. This capability is combined with methods for supporting the co-ordination of the information exchange between agen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Demystifying interface accommodation coefficients in liquid-vapor phase change devices: role of surface charge, contaminant, and confinement'.

assistant: **Objectives**

Liquid-vapor phase change is essential in power generation, heating and cooling, thermal desalination, and membrane distillation. With the advancements enabled by micro/nanoengineering of phase change devices, the interfacial transport resistance becomes increasingly important, dictating the ultimate performance limit. However, fundamental understanding of the interfacial process remains elusive, particularly regarding the interface accommodation coefficients (IACs), which quantify the probability of evaporation and condensation events at the molecular level. Characterizing IACs has been a long-standing challenge, primarily due to the lack of experimental designs sensitive enough to molecule-interface interactions and capable of distinguishing various contributing factors.The DIAL project aims to demystify the complexities surrounding IACs arising from three key factors – surface charges, interface contamination, and nanoconfinement. Here, we decouple these largely overlooked or insufficiently studied factors by designing a series of targeted experiments, leveraging IR and confocal Raman microscopy for combined thermometry and chemical analysis. With evaporating droplets in vacuum, we establish the baseline for IACs first on pure and then on charged and contaminated fluids. Meanwhile, to investigate the effect associated with phase change devices, we characterize contaminant migration and the corresponding impact on evaporation from membranes with microscale pores and at the same time, build a multiscale model relating IACs to device performance. Finally, with evaporation from sparsely spaced nanotube arrays, we examine the nanoconfinement effect on IACs, overcoming the optical diffraction limit.By isolating or minimizing specific effects in each configuration, our expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Organoids For Heartbreak' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

This project is a proof-of-concept study for organoid drug testing platform for disease modeling of cardiac fibrosis. I am going to develop a cardiac organoid on chip platform for disease modeling of cardiac fibrosis to identify the molecular mechanism of the pathologic interplay between endothelial cells, cardiomyocytes and cardiac fibroblasts, and its regulation by specific drug treatments. This model will be based on cardiac organoids previously developed at the host lab modified with endothelial cell component. Organoids with and without endothelial cells will be a tool for identification of endothelial contribution in cardiac fibrosis. Molecular mechanisms will be identified through selective interventions in known fibrotic pathways, with special focus on the Renin-Angiotensin-Aldosterone System. In addition, validity of this tool for drug testing will be established by proof-of-effect of known medications on fibrotic molecular phenotype and cardiac function. The platform will be designed as medium through-put for patient treatment optimization (precision medicine) and drug testing. Collectively, it has the potential to replace animal models in mechanistic research and drug development. The host lab is the perfect fit for this project. It has been on the forefront of cardiac organoid research and their previous work is the cornerstone for the cardiac organoid model used here. They possess the latest equipment for on-chip organoid cultivation and have extensive experience with augmentation and optimization of biopolymer hardness to simulate fibrotic environment. Additionally, Prof. Sluijter’s professional network of contacts and cooperation with local university spin-off companies provides the opportunity to investigate the interest of the industry in application of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New and mature neurons in adult circuits: telling memories apart', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

How does the brain distinguish between memories that closely resemble each other? The hippocampal dentate gyrus has been suggested to serve this purpose by generating non-overlapping memory representations in a process termed “pattern separation”. Intriguingly, during adult life, the dentate gyrus is constantly supplied with new neurons, providing new circuit elements that can incorporate into the neuronal network. How the activity of new adult-born neurons and mature granule cells combines to drive the production and storage of distinct memories represents a new frontier in understanding brain function. However, to determine how these neurons transform similar synaptic input patterns into decorrelated spike output patterns representing distinct memories, we need to monitor and manipulate their subthreshold and suprathreshold activity during behaviour.To address these challenges, we will combine molecular, physiological and optical approaches in the mouse dentate gyrus during navigation in a virtual reality environment. We will use intracellular recordings to assess how hippocampal neurons convert synaptic inputs into spike output, 2-photon Ca2+ imaging to monitor population activity in the hippocampal circuit, and optogenetic tools to causally test the involvement of specific cell types. These experiments will allow us to address the following key questions:1. Which behaviours trigger action potentials in identified newborn and mature dentate gyrus neurons?2. How do synaptic inputs drive spiking in newborn and mature neurons during behaviour?3. How are small changes in an environment encoded by synaptic inputs to newborn and mature neurons?4. Can we differentially manipulate the activity of new and mature cells to selectively interfere with animal behaviour during patt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Role and modulation of Zinc-finger antiviral protein and antiviral Regnase-1-like endonucleases' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The human zinc finger antiviral protein (ZAP) is capable of inhibiting several major human pathogens, including Influenza A virus and SARS-CoV-2. ZAP specifically targets CpG dinucleotides in RNAs and might be one of the reasons why CpGs are strongly suppressed in the human genome. Successful viruses, such as HIV-1 and SARS-CoV-2, mimic human CpG suppression to partially evade the inhibitory effects of ZAP. However, especially under conditions of infection or inflammation when ZAP is expressed at high levels, it inhibits both CpG containing viral as well as cellular RNAs. Importantly, ZAP itself does not possess RNAse activity and is dependent on cofactors, such as KHNYN, to destroy viral RNAs. KHNYN is tightly regulated and inactivated by MALT-1, a cellular protease representing an important target in cancer immunotherapies. Although some progress has been made, the identity of ZAP cofactors as well as their mechanism(s) of action and therapeutic potential are poorly understood. This proposal aims to combine the expertise of the applicant (mechanistic studies of ZAP and RNA-targeting factors) and the host (respiratory viruses and antiviral drug development) to define how ZAP-dependent and independent antiviral endonucleases restrict major respiratory viral pathogens. In addition, it will be examined whether MALT-1 inhibitors that are currently in clinical trials against cancers allow to enhance and maintain the antiviral activity of ZAP and its cofactors thus offering prospects for the treatment of respiratory infections.  Finally, potential side-effects on cellular RNAs and their impact on immune signalling, cell activation and infection outcome will be determined. The project will combine innovative CRISPR/Cas9 genome editing, in vitro virus infection platforms, nove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tracking the North Atlantic water circulation during the Last Glacial period using multi-proxy approaches', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Ocean circulation is a key regulator of climate that driven by both atmospheric and thermohaline processes. The Labrador Sea holds a complex mixture of water masses and plays a crucial role in North Atlantic Deep Water formation and the Atlantic Meridional Overturning Circulation, and thus for global ocean circulation. However, the mechanisms of the Labrador Sea Water formation and its interactions with upper North Atlantic Deep Water remain largely unknown. Understanding the water formation of the Labrador Sea Water and ocean circulation in the North Atlantic region in historical time by using proxy reconstruction data is crucial for benchmarking and understanding the present and future variations using model simulations. The purpose of this proposal is to provide information on the evolution of the North Atlantic intermediate water formation and the impact of changes on ocean circulation in the Labrador Sea during several cold periods including the Last Glacial Maximum, understanding of North Atlantic water inflow, the Labrador Sea deep water ventilation conditions and formation respond to the fundamentally different glacial cold events. By combining benthic foraminiferal morphology and geochemistry data, and other existing proxies, this project will discover the link between shell morphology and multiple stresses, and quantitatively evaluate the impact of changes in the ocean circulation on marine ecosystems. The project aims to apply a multiproxy approach including the application of foraminiferal morphology and geochemistry to reconstruct the seawater conditions. I will generate new high-resolution records of changes in subsurface to deep-water formation in the Labrador Sea region to evaluate the impact of changes in ocean circulation and to significantly improve t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European collaboration in High-Temperature Crack growth' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The objective of the proposed Thematic Network is to provide a focus within Europe for the co-ordination, discussion, standardisation and development of all aspects of crack initiation and growth under creep and/or fatigue conditions in high temperature industrial applications. The particular emphasis will be on research requirements for data generation, analysis and exchange, and industrial experience in crack initiation and propagation monitoring and assessment. The objective of the Exploratory Phase is to assess the severity of problem in industrial applications and the degree of support and demand within industry, research institutes and universities for the establishment of the Network, and to agree on the structure and working of such a Network. The approach of the Exploratory Phase is based on three organisations namely ERA Technology, JRC-Petten and ESB from three European Union countries ie UK, Netherlands, and Ireland, carrying out a broad survey and analysis of the problem within European industry and interest in research establishments, and submitting a formal report to the Commission of the European Union on the findings of the Exploratory Phase. In the event of sufficient support from potential partners, the report to the Commission will be accompanied by a full proposal on the structure and working of the Thematic Network, ie Implementation Phase Proposal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'An integrated approach for biogas production with agricultural waste' (AGROBIOGAS).

assistant: **Innovation**

Annually around 700 million tons of agricultural wastes are produced within the EU which represents a high load for farmers that are obligated to get rid of them. So far, the majority of the time manure and crop residues have been receiving the cheapest treatments although these are not the most adequate ones. Upgrading to biogas by means of anaerobic digestion (AD) represents an alternative treatment with a lot of potential as it not only prevents pollution, but also allows for energy and nutrient recovery.  There are still many challenges to be solved in order to make this technology effective to treat agricultural waste and widely accessible to European farmers. Its distribution is still scattered in the EU and farmers, depending on their location, have different opportunities to apply this technology. It is necessary to clarify which are the best conditions, adapted to local situations to treat the targeted residues and make this information accessible to farmers though the IAGs which represent them.  The possibility of co-digestion opens a door plenty of potential to farmers who could be able to treat their own waste together with other organic substrates. By these means, farmers will treat their own residues properly and at the same time, they could make a profit by treating and managing organic waste from other sources (waste disposal and management fees) and by selling and/or using its outputs: heat and electrical power together with a stabilised biofertiliser.  The aim of the proposing IAGs is to gather and gain knowledge about financial, legal and technical requirements to develop feasible agricultural AD treatments for different local conditions to further transfer it to their SME members. This will strengthen the competitiveness of AD treatment of agricultur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Gamification of participatory science for training and education purposes' (GAPARS) targeting Horizon 2020.

assistant: **Abstract**

Creating effective ways for citizen science is immensely important. Scientists in all fields increasingly rely on active public participation for experiments and analyses of complex and/or massive data, and the outreach and education possibilities of citizen science are enormous.Yet there are three key issues for any citizen science project: (i) reach out to a sufficiently large audience, (ii) lower the threshold to participation as much as possible, and (iii) provide incentives to continue participant engagement.We created Massively Multiplayer Online Science to connect scientific research and video games as a seamless gaming experience. Research tasks completely integrated with game mechanics, narrative and visuals can open up a new channel between the gamer and the scientific community. Converting a small fraction of the billions of hours spent with playing video games will bring an enormous contribution to scientific research, and in the meantime will change how video games’ expertise is perceived.The goal of GAPARS project is to develop and validate the reference platform enabling the injection of scientific tasks into on-line communities, such as gamers. To do so, we gathered a unique team of prestigious participants and one major game editor, all with a track-record of excellence in management and in their respective domain of expertise. This project will put Europe on the map with a new genre of serious games.


**Keywords:** Participatory science, Massively Multiplayer Online Games
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Femur ultrasound scanner (FEMUS)' (FEMUS), addressing dissemination and exploitation.

assistant: **Impact**

Osteoporosis fractures cause a substantial mortality and high costs in the EU with a tendency of further increases. New treatments can significantly reduce fracture incidence, provided that methods for accurate diagnosis of bone fragility are available. Quantitative Ultrasound (QUS) methods have shown potential to predict future fractures, but are limited to some peripheral bones. To improve the diagnosis a QUS scanner for direct measurements at the proximal femur will be developed. Innovations include ultrasound based 3-D bone contour detection and combined transmission/reflection measurements. We expect superior performance in identifying subjects at highest risk for hip facture, the fracture with the most severe consequences of osteoporosis. If successful, the FEMUS QUS femur scanner will have strong potential for commercialisation because of lower cost, lack of ionising radiation, and better patient acceptance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'New approaches for community-driven sustainable mobility innovations at neighbourhood and urban district level'.

assistant: **Concept**

People Oriented Transport and Mobility (POTM) holds a great promise for tackling some of the most persistent urban and peri-urban sustainable mobility challenges of common interest to EU cities. Even though researchers, practitioners and policy makers are aware of this potential, the current research and innovation framework is plagued by a surprising lack of evidence and transformative POTM solutions.Cities-4-People brings together a multidisciplinary consortium to introduce a community-driven POTM framework based on participatory, inclusive and transparent innovation processes. We incorporate collective awareness and open innovation to understand the real needs of EU citizens and co-create new mobility solutions with them, harnessing digital and social innovation. Based on a local community setting and supported by cross-disciplinary teams and a comprehensive suite of collaborative technologies (both online and offline), citizens along with public and private city stakeholders will co-develop concepts and endorse concrete solutions – inspired by growing mobility trends (e.g. shared mobility and connected mobility). The best solutions will be put to the real test in a thorough pilot and scale up program in 5 different EU urban areas with rich diversity in terms of size, population density and socio-economic context. In parallel, the project will introduce an open process to co-develop a common Core Outcome Set of definitions, metrics, indicators and methods to guide POTM impact assessment and place, for the first time, the citizen into the equation. We will use this common baseline throughout our evaluations together with some less traditional techniques (e.g. people as sensors, real time user feedback). We believe that this work will act as the first open standard in