RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Contribution of anthropogenic and biogenic volatile compounds - voc's - to the aerosol formation in ambient air' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content Volatile organic compounds (VOC's), are known to play an important role in the chemistry of the atrnosphere, in particular in the formation of photochemical oxidants e.g. ozone, PAN etc. Moreover, prelirninary evidence indicates that VOC's are contributing to a large extent to organic aerosol formed under atmospheric conditions. Athough many reaction mechanisms for volatile organics are proposed which might explain product formation and distribution, the atmospheric processes which govern formation and growth of aerosols are only partly elucidated. In addition, the complexity of the chemical and physical processes involved in gas-to-particle conversion of organic carbon makes it difficult to relate the organic component of particulate matter to specific sources of the volatile hydrocarbons which act as aerosol precursors. The work proposed aims at clarifying the chemical processes involving selected anthropogenic e.g. cyclohexene and biogenic e.g.limonene hydrocarbons leading to aerosol forrnation as a result of their reaction with atmospheric trace gases e.g. 03, NOx under simulated atmospheric conditions and in the field. Factors which possibly affect aerosol formation e.g. humidity, solar radiation, temperature will be considered too. Training content (objective, benefit and expected impact) Experiments will be carried out in the laboratory in order to investigate the aerosol production by the ozonolysis and photooxidation of limonene and cyclohexene. A method will be developed and tested for sampling the aerosol particles. Analysis will be performed by GC and GC/MS and HPLC. In addition, in field measurements in the greater Athens area the organic fraction of collected aerosols will be analysed. From the results in both the laboratory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Basic research in Nuclear Physics and Neutron Data Standards' (2002-2006).

assistant: **Concept**

Specific Objectives:Several tasks in this action concern experiments and/or theoretical studies of more than one year duration. Therefore, some tasks already started in FP5 and many will run beyond the year 2003;1. Development of improved techniques for charged-particle studies based on digital signal processing techniques;2. Improvement of the database for the B-10 basic cross section standard (branching ratio and total cross sections);3. Measurements of fission fragment properties for Cf-251(n,f) reactions;4. Development of a new experimental setup for mesurements of the Pu-239 (n,f) prompt neutron emission multiplicities at resonance energies;5. Improved modelling of the fission process (cross sections, mass distributions and neutron multiplicities);6. Improved modelling of the Doppler broadening of neutron resonances due to thermal vibrations of the target nucleus in the crystal lattice;7. Demonstration of medical and archaeological applications of the Gelina white neutron source;8. Support to humanitarian activities in the field of demining;9. Establishment of the GELINA and VdG large scale facility as a Marie- Curie training centre Anticipated milestones and schedule For most tasks, the milestones are experimental data sent to the NEA Data Bank and publication in a peer reviewed journal.Several tasks in this action concern experiments and/or theoretical studies of more than one year data analysis. Therefore, some tasks already started in FP5 and many will run beyond the year 2003. Training and Mobility: several actions have been proposed for giving access to the large-scale nuclear facilities of IRMM as training sites at graduate and post-graduate level. These include industrial training courses for engineers at the IRMM accelerators, a JRC Accelerator School, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'INitiation FActor 3 as target in Cancer Therapy' to be submitted under Horizon Europe.

assistant: **Abstract**

Eukaryotic translation initiation is a process wherein ribosomal subunits are assembled by eukaryotic initiation factor (eIF) proteins. Mammalian eukaryotic translation initiation factor 3 (eIF3), consisting of the 13 subunits eIF3a to eIF3m, is the largest and most complex eIF. Due to the emerging understanding of the role of eIF3 in a wide range of cancers, there is an increasing interest to examine its many subunits as potential therapeutic targets. Furthermore, interactions between subunit eIF3c and tumor suppressor protein schwannomin has been reported to promote development of the tumor neurofibromatosis 2 (NF2). Very few small molecule inhibitors reported targeting eIF3 subunits are reported, and are associated with high degree of uncertainty. There is hence a need to develop new and highly effective small molecules targeting the eIF3 subunits to be used in the treatment of cancer, as well as in the fundamental understanding of the interactions between the various subunits.The aim of this interdisciplinary project is to investigate the structures, dynamics, and interactions of subunits in the eIF3 family, and use this information to design, synthesize and test compounds for targeted cancer therapy. We will employ a range of computational and bioinformatics-based tools (protein-protein docking, molecular dynamics and metadynamics simulations, machine-learning based ligand design and docking techniques) to identify and explore key druggable interactions and regions in the initially targeted subunits eIF3a and c. To verify the inhibitory potential of the designed small molecules, chemical synthesis and in vitro evaluation will be performed. Through the combination of computational modeling, subunit-specific inhibition, and measurements of anticancer activity, we wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unifying Control and Verification of Cyber-Physical Systems' under Horizon 2020.

assistant: **Concept**

The proposed research effort provides methods for a faster and more efficient development process of safety- or operation-critical cyber-physical systems in (partially) unknown environments. Cyber-physical systems are very hard to control and verify because of the mix of discrete dynamics (originating from computing elements) and continuous dynamics (originating from physical elements). We present completely new methods for de-verticalisation of the development processes by a generic and holistic approach towards reliable cyber-physical systems development with formal guarantees. In order to guarantee that specifications are met in unknown environments and in unanticipated situations, we synthesise and verify controllers on-the-fly during system execution. This requires to unify control and verification approaches, which were previously considered separately by developers. For instance, each action of an automated car (e.g. lane change) is verified before execution, guaranteeing safety of the passengers. We will develop completely new methods, which are integrated in tools for modelling, control design, verification, and code generation that will leverage the development towards reliable and at the same time open cyber-physical systems. Our approach leverages future certification needs of open and critical cyber-physical systems. The impact of this project is far-reaching and long-term: UnCoVerCPS prepares the EU to be able to develop critical cyber-physical systems that can only be realised and certified when uncertainties in the environment are adequately considered. This is demonstrated by applying our ground-breaking methods to automated vehicles, human-robot collaborative manufacturing, and smart grids within a consortium that has a balanced participation of academ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Development of inhibitors of malarial and trypanosomal dihydrofolate reductase as antiparasitic agents through combinatorial chemistry'.

assistant: **Objectives**

* To test the validity of the combinatorial synthesis approach to antiparasitic drug development, based on the inhibition of the parasite dihydrofolate reductase domain of the bifunctional enzyme dihydrofolate reductase-thymidylate synthase (DHFR-TS), and to develop new drug candidates especially against malaria from this approach.* To understand the relation between structure and function of the parasitic enzymes, the basis for differential inhibition of the enzymes by candidate agents, and the basis for development of resistance.Expected Outcome* The validity of using combinatorial libraries for development of antifolate antimalarials will be tested.* Combinatorial libraries based on 2,4-diaminopyrimidines and dihydrotriazines in solution or on solid supports will be made, as will milligram quantities of recombinant wild-type and mutant malarial dihydrofolate reductases ready for screening.* Appropriate screening methodologies for combinatorial libraries against the malarial enzyme will be established.* Better understanding of inhibitor binding to the enzyme will be achieved.Selected libraries of 2,4-diaminopyrimidines and dihydrotriazines which include known inhibitors of malarial dihydrofolate reductase will be created and screened against recombinant parasite and host enzymes. Libraries will be made both in solution and on solid supports. The second type of libraries will also be encoded with appropriate molecular tags for easy identification of structures. In the first type of libraries, screening will be made against the enzyme, either in free form or linked to an appropriate solid support, while in the second type, screening of the resin-bound libraries will be made against the enzyme linked to an appropriate fluorescent molecule.Enzyme-bound drug candidates can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Diffractive Optical Element Fabrication based on 3D Printing' to be submitted under Horizon Europe.

assistant: **Abstract**

Diffractive Optical Elements (DOEs) are used to shape the wavefront of incident light in complex patterns, and are ubiquitous across optical applications, ranging from laser processing through lithography to communication and imaging. Despite their popularity, fabricating DOEs is non-trivial, mostly due to their nanoscale-precision requirements, necessitating highly precise, expensive and cumbersome fabrication methods (typically using photolithography), which are also limited in the design flexibility they allow. During the PI’s ERC-StG, we developed a method to enable simple, fast, and high-quality fabrication of DOEs, by combining 3D printing with near-index matching by liquid-immersion.  This results in DOEs comparable in performance to the state-of-the art, yet manufactured at a fraction of the cost and time. Still, at this point, these DOEs need to be immersed in a small liquid-containing chamber to operate, which prevents mass adoption of the technique by the market. Hence the main goals of this PoC: We will adapt our 3D-printing based near-index matching technique to yield fully solid DOEs, fabricate and demonstrate several proof-of-concept industry-relevant elements, and explore various strategies to bring our technique to the market. Our technology has the potential to transform the world of DOE fabrication by drastically simplifying the fabrication process, shifting the relevant scales from weeks to hours, from thousands of dollars to a few dollars per element, and finally – alleviating the need for a cleanroom environment, which will significantly democratize the process of DOE fabrication, making it available in low-resource settings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Engineering magnetic properties of hexagonal boron nitride - based hybrid nanoarchitectures' (WHITEMAG).

assistant: **Concept**

2D magnetic materials have attracted enormous interest over the last years because of their potential towards miniaturization of novel low-power and memory storage technologies. Isostructural and isoelectronic to graphene, an atomically-thin layer of hexagonal boron nitride (hBN) is electrically insulating, and one of the most prominent 2D materials because of its superior mechanical, thermal and especially chemical properties. Inducing magnetic properties (together with reducing the size of the bandgap) will allow the realization of full potential of hBN nanostructures in functional applications. In this line, the efforts reported to date lack characterization and control of the sample’s properties at the atomic level, which is crucial to achieve a comprehensive understanding of the physical phenomena driving the emergence of magnetic properties.WHITEMAG aims to create routes for controlled magnetic functionalization of hBN in order to induce and exploit emerging electronic and magnetic properties at the atomic scale. hBN will be precisely modified by exploring novel defect engineering methods to introduce substitutional magnetic atoms, and subsequently by designing hybrid nanoarchitectures that combine hBN with magnetic organic molecules. The structural, electronic and magnetic properties of these systems will be studied by STM/STS, XPS/ARPES, nc-AFM and XMCD, giving a complete picture of the phenomena occurring at the atomistic level. The synthesis and characterization experiments will be addressed based on a surface science approach, involving controlled dosing of molecular and atomic species on well-defined surfaces under ultra-high vacuum (UHV) conditions. If successful, the outcomes of this work will push forward the microscopic understanding of magnetic phenomen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A breakthrough in rechargeable N-Halamine technology for unparalled antimicrobial efficacy on hard surfaces' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Exigence SymbiCoat™ represents a fundamentally different approach for creating materials which can prevent pathogens from surviving on a surface, and can also inhibit the presence of dangerous biofilms.The technology is revolutionary when compared to the products that dominate today’s antimicrobial coatings market. Most antimicrobial coatings rely upon a relatively simple but flawed premise. A toxic active ingredient, such as silver, copper or zinc in various forms, is impregnated into the coating. That active ingredient leaches out to contact and kill germs. This means the store of the chemical that provides the antimicrobial action is relatively quickly depleted — very soon, the ‘antimicrobial’ product has very little positive activity or effect at all. In addition, this leaching of toxic chemistry has negative implications for the aquatic environment, food safety and human and animal health. SymbiCoat™ chemistries modify existing coating materials (vinyls, epoxies, polyurethanes and others) through a method that does not contain a disinfecting chemical or active ingredient. Instead, SymbiCoat technology provides a remarkable capability to the newly modified materials: the ability to rapidly bind the ECHA (European Chemical Agency)-registered  chlorine bleach into ‘receptors’ in the coating. Chlorine bleach is one of the most widely used, cost-effective and well understood disinfectant chemicals available globally. Exigence SymbiCoat™ allows the chlorine bleach to provide a much longer period of action than would otherwise be possible, even at levels that are safe for food contact. Thus, SymbiCoat has the potential to radically enhance the contamination control in the food industry, helping prevent the spread of resistant bacteria and foodborne diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A comprehensive and Multi-facetted Study of Stellar Explosions and Eruptions using Radiation-Hydrodynamics and Time-Dependent Radiative Transfer Techniques', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Stellar explosions and giant outbursts from massive stars like Eta Carina constitute highly energetic events where radiation constitutes a critical dynamical ingredient as well as a fundamental probe of the event, opening to our eyes the Universe at large.We propose to adapt, improve, and apply our radiation hydrodynamics and radiative transfer codes to model such astrophysical phenomena. Capitalizing on our former studies, we will model the spectra, light curves, and the polarization signatures of  supernova (SN) explosions,interacting supernovae, as well as the giant outbursts of Luminous Blue Variables (LBVs). Our results  will provide constraints on pre-SN massive star evolution and mass loss;  stellar explosion mechanisms, energetics, and morphology; the identity of SN progenitors; the connection between SN explosions and SN impostors like LBVs; and finally, cosmology through the use of SNe for distance determinations in the Universe.Some specific projects we will address are 1) Type II Plateau SNe and the Expanding Photosphere Method; 2) Type Ia SNe and the width-luminosity relation; 3) Type Ib/c SNe and the connection to X-ray-flashes/Gamma-ray-bursts;  4)  interacting SNe such as the extremely luminous SN 2006gy or the low-mass SN 2008S; 5) shock breakout; 6) the potential explosive origin of LBV giant outbursts.The multidisciplinary aspects of this proposal cover the nature and origin of stellar explosions and mass loss, which represent key questions of modern astrophysics. Our theoretical results will be confronted to observations, and will also motivate new programs on 8m-class telescopes.  Based on an ongoing collaboration with researchers in the US (Hillier, Owocki) and in Israel (Livne), this proposal will assist with the reintegration of theapplicant in E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Gene therapy for Epidermolysis Bullosa: a model system for treatment of inherited skin diseases', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The project aims to develop a gene therapy technology model based on autologous transplantation of skin made in vitro from genetically modified epidermal stem cells. This includes developing vectors, gene transfer technology, and preclinical models of gene therapy of rare inherited defects treatable with local delivery of a recombinant protein. The research focuses on dystrophic epidermolysis bullosa (DEB), a rare, disabling skin disease caused by inherited defects of collagen type VII. The workplan consists in: - Recruiting, genotyping and characterizing at molecular level cohorts of patients with recessive and dominant DEB - Isolating epithelial stem cells from the skin of DEB patients and DEB dogs, a spontaneous large animal model for the disease - Developing viral vectors (oncoretroviral, lentiviral, and hybrid adeno/AAV vectors) to integrate and stably express the collagen VII cDNA in DEB epidermal stem cells ex vivo - Transducing highly clonogenic DEB keratinocytes with the most appropriate vector(s) - constructing skin equivalents made with genetically corrected DEB cells to assess the full morphological and functional reversion of the DEB phenotype - Constructing transplantable epithelia using genetically corrected DEB cells and preclinical assessment of their performance in vivo in appropriate immune competent animal models - Developing a technology for production and downstream processing of clinical-grade viral vectors preparations under GMP/GLP standards -Establishing SOP, protocols and guidelines to genetically modify epidermal stem cells used to produce skin implants for clinical use- Disseminating results. The project's immediate goal is to develop a gene therapy approach to DEB and design appropriate phase I/II clinical trials to exploit the knowledge ge