RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'STEM CELL PLASTICITY IN ADULT NEUROGENIC NICHES' (NSC-PLAS).

assistant: **Innovation**

Somatic stem cells (SCs) sustain tissue renewal and regeneration in adult mammals. The maintenance of their stemness and long-lasting preservation in cohabitation with differentiated progeny at specific niches poses these cells to a considerable challenge. To deal with it, SCs display a complex network of yet to be fully uncovered mechanisms that allow multilevel plasticity. Cellular plasticity indicates the ability of cells to reversibly change their phenotype in response to the microenvironment. In the subependymal zone of the adult rodent brain, self-renewing neural SCs (NSCs) generate new neurons for pre-existing olfactory circuits. It is clear that NSCs must be endowed with plasticity properties, but the analysis of these potential traits needs a precise definition and a combination of comprehensive approaches to unravel their molecular regulation. Building from our new technologies and some preliminary data, in this proposal we will try to advance in the molecular basis and extent of the cell plasticity repertoire of adult subependymal NSCs by concentrating in three of its potential forms:Epithelial plasticity, or the ability to dynamically and reversibly undergo epithelial-to-mesenchymal transitions, a form of cell adaptation that has never been conceptually proposed or evaluated in adult NSCs.Cycling plasticity, or the ability to move in and out of the cell cycle and remain quiescent for long periods of time. This plasticity clearly exists, but its molecular regulation remains largely elusive.Immune plasticity, or the capacity to evade adaptive immunity. Our view about immunity in the brain has dramatically changed in the last few years, raising interest in its potential interaction with NSCs.Understanding cell plasticity traits in NSCs may contribute to underst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Quantum Local Area Networks with Superconducting Qubits', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Superconducting quantum circuits are one of the most promising platforms for realizing large-scale quantum computing devices, where in the near future a coherent integration of 100-1000 qubits is feasible. However, the required temperatures of only a few mK currently restrict quantum operations to superconducting qubits that are located within the same dilution refrigerator. This imposes a serious constraint on the realization of even larger quantum processors or the implementation of local- and wide-area quantum networks based on superconducting technology.The targeted breakthrough of this project is to overcome this limitation by demonstrating for the first time the operation of a quantum local area network (QuLAN), where superconducting qubits housed in spatially separated refrigerators are connected via a cryogenic transmission line. Using this setup, we will implement state transfer protocols and distributed quantum algorithms between superconducting qubits that are tens of meters apart. In parallel, we will develop and demonstrate new electro-optical quantum transducer designs for fast microwave-to-optics conversion and many other essential components and protocols for efficiently integrating multiple superconducting quantum computing units into a single coherent network.  The outcomes of this project will enable the non-incremental step from intra- to inter-fridge quantum communication and will facilitate the implementation of first quantum computing clusters. In the long run, this technology provides the basis for the realization of metropolitan-area scale quantum networks using superconducting circuits.  The project will be carried out by an interdisciplinary team of experts in the fields of superconducting circuits, nanophotonics and quantum information theory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Theory of Fair Machine Learning' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Designing fair machine learning algorithms is challenging because the training data is often imbalanced and reflects (sometimes subconscious) biases of human annotators, leading to a possible propagation of biases into future decision-making. Besides, enforcing fairness usually leads to an inevitable deterioration of accuracy due to restrictions on the space of classifiers. In this project, I will address this challenge by developing oracle bounds of fairness restraints and a Pareto-dominated trade-off between fairness and accuracy using ensemble classifiers with the majority vote, to cancel out not only errors but also biases. I will also develop illegal bias tracing and long-term fairness capturing to comply with anti-subordination lawfully, using learning theory tools including causality and online learning for moral responsibility. The central objective of this proposal is to gain a theoretical understanding of fairness and to design machine learning algorithms that simultaneously improve both fairness and accuracy. The study is essential both for improved scientific understanding of fairness in machine learning models, and for the development of fairer algorithms for the numerous application domains, such as recruitment, criminal judging, or lending. Moreover, the project also takes interdisciplinary knowledge of economics and law into account to avoid fairness concepts in machine learning from being misaligned with their legal counterparts, enlarging the impact of machine learning applications and giving back to the wider community.


**Keywords:** Fairness, machine learning, majority vote, causality, multi-armed bandits
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Engineering the catalytic properties of Trichoderma reesei cellobiohydrolases' (1994-1998).

assistant: **Innovation**

The filamentous fungus Trichoderma reesei produces two potent cellobiohydrolases, CBHI and CBHII. The two enzymes have different structures but both have active sites located in enclosed tunnels containing constellations of amino acids that interact with each other and the substrate. Our earlier studies and comparisons of the enzymes with homologous cellulases provide narrow structural constraints for proposed catalytic mechanisms and suggest residues whose mutation will alter pH-dependencies. Our objective is examine and engineer the catalytic mechanisms of T. reesei CBHI and CBHII by state of the art methods in molecular and structural biology and bio-organic chemistry. A detailed model of the interaction of a cellulose chain with these enzymes will be generated by crystallographic analysis of mutant enzymes in complex with natural and modified oligosaccharides. Novel mechanistic probes will be used to establish still unknown details of the mechanisms of the wt enzymes, and to delineate changes of mechanism in the engineered proteins. An exhaustive search of interactions in the active site, carried out by making a range of systematically modified inhibitors and probes, together with complementing mutations in the enzymes will lead to iterative improvement of the active site. This will allow us to raise the pH optima of the two enzymes. Cellulolytic enzymes are already used in e.g. textile and paper industry. Genetic engineering, when combined with structural biology and a solid background in enzymology provides powerful means for learning and improving the enzyme function. In this proposal, all these aspects are included making possible significant advances in the understanding and engineering the catalytic mechanisms of cellulases. Since the same catalytic principles
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Automatic publication under LInked DAta Paradigm of library DAta' (ALIADA) targeting Seventh Framework.

assistant: **Abstract**

ALIADA (ally in Spanish, female genre) will automatize the publication in the Linked Open Data cloud of open data hosted by different Library or Collection Management Software. ALIADA will support the whole life cycle of reuse of multilingual open data from public bodies, initially the ones in the consortium, providing a usable and open source tool that automatize the selection, publication and linking of datasets in the Linked Data Cloud by the ALIADA users: IT staff, documentalists, curators and librarians in institutions that own datasets managed by library and/or museum management software. ALIADA will be an open source plugin for the library or collection management software, initially for the ones developed by the SMEs in the consortium and already installed in the public bodies, opening the SMEs' market to new business opportunities. Usability in ALIADA solution will be a key aspect, as the final users will have little or no experience in Linked Data technologies and processes.Librarians are used to manage the collections, they are responsible of, using Library or Collection Management Software that follows norms such as MARC21 and LIDO resulting in high quality annotations. The collection and library software is focused on facilitating the cataloguing fiche entering / consult but, although following a worldwide accepted norm and vocabularies, the databases are proprietary and lock free access. These proprietary solutions hamper the interoperability between different vendors of Library or Collection Management Software and when accessed by external applications that wish to make innovative use of such rich formal data, act as a barrier when opening the data to the world and to innovative SMEs that wish to exploit the possibilities of such information. ALIADA will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NEW VALORISATION OF RAPESEED/SUNFLOWER LECITHINS, A BY-PRODUCT OF SEED OIL, IN COSMETIC AND FERMENTATION INDUSTRIES : USE OF NATURAL PROTEIN CARRIERS OF PHOSPHOLIPIDS OVERPRODUCED BY FILAMENTOUS FUNGI GROWING ON LECITHIN SUBSTRATES' (AVAIL), addressing dissemination and exploitation.

assistant: **Impact**

The objective of this project is to valorize european rapeseed and sunflower lecithins, a by-product of seed in high added values products for cosmetic and fermentation industries. European soja lecithins will be used as reference in this project.This non food valorisation will be carried out in an integrated approachassociating complementary private partners (1) a lecithin producer for preparationof new lecithin mixtures from rapeseed sunflower; (2) a fermentation companyusing lecithins as the sole carbon source, first for the overproduction highly activecarriers of phospholipids (Phospholipid Transfer Proteins -PLTP) by the fungusAspergillus oryzae and secondly on the overproduction of important fungalindustrial enzymes in response to lecithin supplementation; (3) a cosmetic companycombining this highly active fungal PLTP and lecithins to generate new liposomeformulation to develop 'new', 'natural' and 'efficient' cosmetic applications. Thismultidisplinary and complementary industrial approach will be realised in closeassociation with (4) academics to study production processes of fungal PLTP,structure-function of PLTP in relation with membrane biogenesis and definition ofa generation of new liposome. In spite of their strong potential as drug delivery systems, liposomes have actuallyfound their first industrial applications in the field of cosmetics where they havelead to considerable commercial success. The purification and characterisation forthe first time of a novel highly active PLTP from A. oryzae growing on lecithinfractions as the sole carbon source open new prospects for improving theefficiency of liposomes in cosmetics.This project leading to a better valorisation of european plant lecithins (rapeseedand sunflower) in cosmetics and to the development of a n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'SysML bAsed modeling, architecTUre exploRation, simulation and syNthesis for complex embedded systems'.

assistant: **Objectives**

SATURN's goal is to bridge the current gap between modelling and verification/synthesis in UML based designs of Embedded Systems that are equally composed of HW and SW. To do this, the UML profile for MARTE is evaluated for its complementary application with SysML, and significantly improved adding formal semantics of different Models of Computation for integrated modelling and verification environments. By bridging this gap, SATURN expects to demonstrate a significant reduction in time-to-market. <br/><br/>This will be delivered through: (a) the augmentation of SysML with MARTE, (b) the use of MARTE as a platform to integrate SysML with a run-time environment for cross-domain verification, (c) the automatic generation of implementable descriptions for both hardware (SystemC/VHDL) and embedded software (C/C++) components of the targeted system, and (d) the integration of different abstraction layers allowing seamless integration at functional and target architecture level. <br/><br/>Results are validated by two complex industrial proof-of-concept case studies covering a smart camera system and an outdoor broadband wireless telecom system. <br/><br/>SATURN combines two SME tool vendors (Artisan and Extessy AG) with leading system houses (Intracom S.A. Telecom Solutions & Thales Security Systems S.A.S). The consortium also includes two major European Universities: Paderborn University & University of Cantabria. SATURN enables Artisan to build on its leading position in engineering based UML tools (extending SysML based on Artisan Studio) while Extessy will benefit from the project by increasing their respective market in verification infrastructures. Taking advantage of the open platform of Extessy AG, the SATURN process will be extremely flexible, and integrate with diff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pattern formation in the c. elegans embryo and interactions between the even-skipped homologue vab-7 and hox genes' (1994-1998).

assistant: **Concept**

Research objectives and content A conserved cluster of homeotic genes (the HOM-C) patterns animals along the anterior/posterior axis. However, they are not expressed at the anterior and posterior extremities. One gene proposed to have a role in posterior patterning in most animals, possibly in concert with HOM-C genes, is even-skipped. However, neither their posterior function nor any functional interaction with HOM-C genes was known. Recently, it was shown that the C. elegans even-skipped homologue is encoded by vab-7, which functions in posterior muscle and epidermal patterning. Further, vab-7 activity is required for expression of the HOM-C gene, egl-5, in muscle cells. The purpose of this proposal is to explore interactions between vab-7 and HOM-C genes. This will involve analyzing cell lineages in HOM-C mutant and vab-7/HOM-C double mutant embryos, examining the consequences of ectopic vab-7 expression on HOM-C gene expression, and searching for vab-7 responsive elements in the egl-5 promoter. Because vab-7 has a posterior expression pattern similar to that of even-skipped in other animals, this work may uncover general developmental principles and patterning strategies. Training content (objective, benefit and expected impact) During my thesis I studied the origin of osteoclasts (F.one resorbing hemopoetic cells) in chicken. Through this work, I learned general cell biology techniques and gained a good knowledge of vertebrate differentiation. During the course of my research, I became more interested in developmental biology, and decided to work in a model system to study embryonic pattern formation. The present project will give me an opportunity to learn new techniques and apply my previous knowledge to the study of developmental questions, taking advantage of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Non technical aspects of demand side management in European electricity markets'.

assistant: **Objectives**

A Multi-disciplinary team of experts comprising energy economists and planners, power sector demand side management (DSM) specialists, marketing specialists, and behavioural scientists will examine the barriers and impediments to demand side management in the electricity sector. This consortium will examine Europe's rapidly changing power sector market to define optimal approaches that governments, utilities and policy makers could adopt to promote demand side management, particularly in the domestic sector. This will provide government and utilities with information and guidance on what DSM approaches will work best within Europe's rapidly liberalising electricity sector, and on what benefits can be anticipated from such actions. DSM is a key element in the European Commission's objectives for reducing emissions and mitigating climate change. As world electricity markets liberalise, and traditional producer-consumer relationships change, it will be important to identify new strategies for promoting and accelerating the uptake of DSM. In particular, the growing power of the consumer in the electricity marketplace is an important new development that has been little studied in Europe as yet. Utilities and governments need to develop a better understanding of how and why consumers respond to demand side initiatives so that they can devise incentives and policies to promote their wider adoption. Furthermore, they need to understand how best new and emerging regulatory agencies in the electricity sector can work with industrial, commercial and domestic consumers to promote DSM more effectively and economically in a climate of increasing consumer power over the marketplace. The project will provide a clearer understanding of the major factors affecting DSM in Europe, and thr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ascidian development and cytoplasmic reorganizations: dissecting the mechanisms that pattern developmental determinants and shape embryonic development' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

What makes a head different from a tail? In many animals, the asymmetries that underlieThe asymmetric distribution of cytoplasmic domains and RNAs is critical for asymmetric cell division and fate determination. Therefore, unraveling the mechanisms that drive the asymmetric distribution of the cytoplasm is essential for understanding animal development. Once fertilized, ascidian eggs undergo a massive cytoplasmic reorganization that precisely localizes developmental determinants (proteins and RNAs) to establish the anterior-posterior body axis. Following this reorganization, an invariant cleavage pattern predictably segregates determinants asymmetrically into blastomeres, conferring differential cell fates. Thus, polarity in the ascidian egg determines the body plan of the whole animal. Despite its vital role in establishing embryonic patterning, remarkably little is known about the mechanisms that orchestrate cytoplasmic reorganization and the distribution of developmental factors. In this project, I will use develop a multidisciplinary approach, combining  high-resolution microscopy and force and cell shape manipulations, proximity biotinylation, proteomics, and transcriptomics to address the following fundamental questions: 1) What mechanisms regulate cytoplasmic reorganization and anterior-posterior polarity in the ascidian egg? 2) How is cytoplasmic reorganization translated into the precise positioning of developmental determinants? This study will shed light on the processes that define the anterior-posterior body axis and pattern of development in ascidians and deepen our understanding of how embryogenesis is conserved and has evolved among chordates. Throughout this project, I will not only acquire new technical skills but also build upon my project management,