RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Spousal Reunification and Integration Laws in Europe' under Horizon 2020.

assistant: **Concept**

RE-NUP will study the implementation of integration laws in three Europeans countries through the perspective of their primary target groups (spousal visa applicants) as well as the nature and scope of the mandatory education acquired as part of integration requirements. While immigration laws have been a topic of substantial academic interest, the modes through which immigrants themselves negotiate integration laws and its rigorous application in reunification cases continue to be under-represented. In my previous publications on the interface between the institution of marriage and legal spaces in North India, I have proposed a reconceptualization of the state where sexual subjectivity is not only a source of marginality and vulnerability, as often perceived in scholarly literature, but also an aspirational goal for some. RE-NUP will develop on this reflection further to understand how laws influence and are, in turn, shaped by the divergent ways in which the institution of marriage is defined and practiced in South Asia and Europe. Through ethnographic research among Indian and Sri Lankan Tamil diaspora, I will study how marital ties are forged through an interface with transnational state agencies that determine the validity of marriages while assessing visa/permit applications. How do European states classify and evaluate marital ties across cultural frameworks? Does the concept of cultural expertise facilitate the process of translating cultural norms? This fellowship will give me an opportunity to undertake specialized training in the field of cultural expertise, combine research with applied work, and extend my competencies in project development, diversity management and intercultural education through an intersectoral secondment and training on transferable sk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Development and distribution of key biotechnoligical arabidopsis thaliana resources'.

assistant: **Concept**

Arabidopsis thaliana is one of the most favoured model systems for the study of many aspects of plant metabolism, development and disease resistance. Although Arabidopsis is of no economic importance itself, understanding basic developmental processes in this plant will facilitate the manipulation and improvement of crops which are vital to European agriculture. The reason for this stems from the fact that all higher plants are closely related. Arabidopsis genes will have similar or identical functions to those found in crops. Hence, by studying a simply organized model, rapid progress can be made in the gene cloning and functional characterization of genes which can improve crop productivity. The physical organization of the Arabidopsis genome is being analysed through the construction of a physical map and the concomitant sequencing of genomic DNA and cDNAs, funded through the EC ESSA Programme. This will facilitate the identification and physical localization of many genes. A complementary approach to identifying genes of agronomic importance, involves the use of mutants. Mutants can be generated by many different means, including chemical or irradiation mutagenesis and insertion of T-DNA or transposons, into coding or promoter regions. Mutants can be used to dissect metabolic and developmental pathways, as well as analyse gene interaction. Arabidopsis has a haploid genome size of approximately lOOMb and contains approximately 20,000 genes. There are currently approximately 10,000 mutagenized lines available for research but to achieve saturation mutagenesis at least 100,000 mutants need to be generated. In the last few years new methodologies have been developed which allow large populations of mutagenized lines to be generated where the mutation is tagged through t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Motivation–cognition interaction in healthy ageing and Parkinson’s disease' in the context of a Horizon 2020 call.

assistant: **Objectives**

Europe is greying. This has enormous economic and social costs for the entire society, through greater numbers of healthy older adults with cognitive decline, and of people with neurodegenerative disorders that can lead to dementia, such as Parkinson’s disease (PD). MOTIVAGEING aims to address this issue by proposing a new approach for the enhancement of working memory (WM) capacity, in order to improve cognitive function, quality of life and wellbeing of healthy older adults and PD patients. In fact, there is no current effective treatment for age-related WM decline or WM deficits and related behavioural and affective problems in PD patients. Based on a promising new theory of cognitive neuroscience, the Motivation-Cognition Interaction (MoCoInt) framework, the present plan employs an interdisciplinary approach: in Study 1, an innovative multimodal functional neuroimaging method is proposed to analyse for the first time the neural mechanisms of MoCoInt in healthy ageing. The new evidence will provide a foundation for Study 2, in which the efficacy of a novel WM training procedure, based on MoCoInt, will be tested in healthy older adults in order to improve their WM capacity. Finally, to understand if this new training procedure can be employed to treat WM deficits in PD, Study 3 investigates for the first time MoCoInt mechanisms in PD patients in relation to pharmacological treatment, through the conduct of a randomised controlled drug trial. Results will enable to extend MoCoInt to healthy and pathological ageing, and to develop a new framework that will be available as a new theoretical model for both researchers and clinicians. MOTIVAGEING will therefore have both a significant scientific multidisciplinary impact, filling several gaps in knowledge in cognitive neuro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ImmunoGrid - The European virtual human immune system project' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The ImmunoGrid is an implementation of virtual human immune system using grid technologies. It can simulate immune processes at natural scale and provides tools for applications in clinical immunology and the design of vaccines and immunotherapies. The developed set of tools will be validated with experimental data and used in clinical applications for development of immunotherapies in cancer and chronic infections. Computational models are applicable because immune system is complex and has combinatorial nature, experimental approaches are expensive, and there are restrictions on the experimentation that can be performed in humans.The ImmunoGrid project is highly relevant to the IST Call 4, its objectives, focus, and roadmaps. The target user groups are clinicians and the developers of the vaccines and immunotherapies. The ImmunoGrid applications will provide tools for clinicians and vaccine/immunotherapy developers for identification of optimal immunisation protocols. The unique component of this proposal is that it aims at connecting molecular level interactions (which regulate immune responses) with system level models (which study behaviour of the immune system as a whole). This is a novel approach to disease prevention and treatment which will help improve human health. Applications of the ImmunoGrid include modelling of the natural-size complex system on a large scale. Another important contribution of the ImmunoGrid will be the implementation of individual immune system models across the grid nodes.This fits well into the roadmaps for research and developments in ICT for health focusing on the development of an in silico model of a human being (virtual human).ImmunoGrid will be developed by an European consortium with members from Italy, France, UK, Denmark, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Supramolecular materials for organic electronics: unravelling the architecture vs. function relationship'.

assistant: **Objectives**

SUPRAFUNCTION aims at mastering principles of supramolecular chemistry, in combination with top-down nanofabrication, to achieve a full control over the architecture vs. function relation in macromolecular materials for organic electronics, by analyzing and optimizing fundamental properties through which new capacities can emerge.Highly ordered supramolecularly engineered nanostructured materials (SENMs) will be self-assembled from conjugated 1D/2D molecules, and ultra-stiff multichromophoric arrays based on poly(isocyanides). Their interfaces with chemically functionalized top-down/bottom-up nanofabricated electrodes and with dielectrics will be tailored to reach SENM energy barriers with height <0.1eV and interface roughness of 3-7Å. Multiscale characterization of SENMs, nanoelectrodes and various interfaces will be done by Scanning Probe Microscopies, ultraviolet photoelectron spectroscopy and other methods, especially to quantitatively study 3 relevant properties, viz charge injection at interfaces, charge transfer, and photoswitching current through a molecular material. Prototypes of nanowires and Field-Effect Transistors (FETs) will be fabricated especially focusing on (1) unravelling charge transport vs. charge injection, (2) the effect of photo-doping in electron acceptor-donor dyad based SENMs, and (3) novel photo-switchable FETs based on either (i) photo-responsive azobenzene SAMs chemisorbed on electrodes/dielectrics to reversibly modulate the charge injection at interfaces, or (ii) electroactive SENMs of dithienylethenes featuring extended conjugation in the side arms to promote a light tuneable p-p stacking among adjacent molecules, ultimately affecting the charge transport in stacks.The generated knowledge will offer new solutions to nanoscale multifuncti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Efficacy of an 11-valent pneumococcal conjugate vaccine in preventing radiologically confirmed pneumonia in the philippines' (ARIVAC-3), addressing dissemination and exploitation.

assistant: **Impact**

The general objective of the research is to find an effective primary prevention for a significant fraction of serious acute respiratory infections (ARI), especially of severe ARI and related severe disease , in infants and children in developing countries . This will be achieved by studying the effectiveness of the 11-valet pneumococcal conjugate vaccine in preventing childhood pneumonia in the Philippines within a population-based randomised placebo-controlled , blinded study . Scientific questions., including transmission of pneumococci will be addressed in nested studies and a specific household carriage study in Bangladesh . The minimum sample size of 10 260 children to be enrolled within 3 years time is calculated on the basis of the primary hypothesis . An interim analysis is planned at end of 3rd year . The final results within 5 years will be directly applicable to countries in the South-East and East Asian region, and more widely to the large and growing number of developing countries with a moderate infant mortality rate of 40-60 /1 000 live births .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Impact of exposure to chemicals to the onset and progression of Lewy Body Dementia' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

With aging, the incidence of neurodegenerative diseases is increasing. Clinical manifestations of neurodegenerative disease often result in dementia, a group of symptoms including loss of memory and impaired cognitive functions that have serious consequences for the wellbeing of aging individuals and society. Dementia is a syndrome of many diseases, including Lewy body dementia (LBD). Whilst the genetic factors contributing to the development of LBD have been investigated, links between exposure to chemicals and LBD have not been sufficiently studied. The FRANKIE project aims to comprehensively investigate the chemical exposome of patients with LBD and elucidate underlying mechanisms of exposure-related neurotoxicity. Blood-based chemical exposure agents and metabolites of LBD patients will be measured via a unique dual liquid chromatography coupled to high-resolution mass spectrometry platform. Advanced statistical and data mining methods will be employed to associate chemical exposures with dysregulated metabolic pathways to identify biomarkers of effect. Furthermore, by comparison of metabolic profiles of healthy people, people with early LBD and LBD patients, novel prodromal and clinical blood biomarkers will be identified. The proposed interdisciplinary, data-driven study is a big step towards understanding the influence of everyday chemical exposure on the onset and progression of neurodegenerative disease. The FRANKIE project will produce mechanistic insights of chemical exposure-related neurotoxicity, providing the opportunity to identify prevention measures and potentially reduce the incidence of neurodegenerative diseases to improve the quality of life of the elderly and aging populations and contribute towards a healthier society.


**Keywords:** exposome, ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Impact of BRCA2 deficiency one the DNA damage response and Immunogenicity of Prostate cancer after  Radioligand therapy' (BRCA-RLT).

assistant: **Innovation**

Despite current advances in prostate cancer (PCa) treatment, 10 to 20% of PCa will evolve to a metastatic stage, where the overall survival is 14 months. Radioligand therapy (RLT) is a new, promising treatment consisting in the injection of a radiolabelled vector. In PCa, this therapy targets Prostate Specific Membrane Antigen, which is overexpressed on PCa cells compared to other tissues. RLT has been shown to increase the overall survival of patients in clinical trials, but in order to improve its efficiency and identify possible biomarkers for patient selection, tumour response mechanisms must be studied.Especially, some reports indicate that deficiency in DNA Damage Response (DDR) genes could be correlated to an increased sensitivity of tumour cells towards RLT. In PCa, one of the most frequent deficient DDR gene is Breast cancer 2 (BRCA2), which is correlated with bad prognosis. In addition, retrospective studies showed a potential link between BRCA2 deficiency and a modulation of the immune response, which also influences treatment response. Therefore BRCA2 deficiency could impact both the immune response and RLT outcome. In this project, I will investigate the impact of BRCA2deficiency on RLT response. Both the tumour DDR and immunogenicity will be assessed, in order to view the treatment response as a whole. These studies will be conducted in vitro in murine and human PCa cell lines and in in vivo murine model. Results of my project will show the impact of BRCA2 deficiency on RLT outcome and whether BRCA2 status could be used as a biomarker to predetermine potential good responders to RLT. Besides contributing to the fundamental scientificadvancement on the effect of BRCA2 deficiency in RLT response, I also aim to raising the awareness of these principles in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'International Training for Doctoral Research on Advanced Gene and Cell Therapies' (RAREFIND).

assistant: **Innovation**

The RAREFIND project is an innovative doctoral training program designed to meet the growing need for specialized education in advanced gene and cell therapies. Coordinated by Fondazione Telethon (FTELE) with the School of Advanced Studies (IUSS) as implementing partner, RAREFIND offers a dynamic interdisciplinary and intersectoral training environment. The program encourages international mobility and promotes excellence in research across FTELE’s leading institutes, TIGEM and SR-TIGET, both recognized for their pioneering contributions to genetic research and therapy development. RAREFIND aims to train 22 doctoral candidates (DCs) through cutting-edge research projects on gene therapy, gene editing, and related fields. Participants, selected through a rigorous and competitive process, will receive comprehensive education combining scientific expertise with transferable skills. They will gain hands-on experience in leading laboratories, collaborate closely with non-academic entities, and benefit from secondments and specialized training. This approach ensures exposure to a broad range of perspectives, preparing DCs to advance the development of personalized therapies for rare genetic diseases.A key pillar of the program is its emphasis on career development. RAREFIND offers tailored mentorship, targeted professional skills training, and opportunities to engage with leaders from academia, industry, and regulatory bodies. This holistic approach ensures that graduates are equipped not only for academic research careers but also for leadership roles in biotechnology, pharmaceutical companies, and other sectors in gene and cell therapies. By integrating translational research with real-world applications, RAREFIND accelerates the transformation of scientific discoveries int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Air Quality Monitoring Technologies for Urban Areas' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

With increasing requirements for air pollution monitoring in Europe, and a rising number and complexity of available instruments, harmonisation and innovation of air pollution monitoring in Europe is of vital importance. In the short term, harmonisation is needed to ensure comparability of measured concentrations, and their estimated measurement uncertainties, provided by European air pollution monitoring networks. To achieve harmonised air quality data, detailed recommendations on equipment evaluation and selection, standard operating procedures (SOPs) for set-up, operation and calibration, and proofs of equivalence to reference methods are needed. The necessity for harmonisation is especially important for particles (PM2.5 and PM10). Demonstration of equivalence to the reference methods, and QA/QC procedures for widely used automated PM monitors, are key current issues. In the longer term, the regulatory requirements for both metrics and methods need to be re-examined in the light of improved scientific knowledge (for example relating to health effects) and advances in monitoring technologies.The aim of AirMonTech is to compile the knowledge and information needed to harmonise current air pollution measurements and to guide research and decisions about monitoring in the future. The project is proposed by a consortium comprising air quality monitoring experts, measurement technique developers and health effect researchers from renowned research institutions and public bodies. Strong links to both urban and regional monitoring networks and European standardization institutions are ensured via direct links to AQUILA, EMEP and CEN. AirMonTech will gather information on instrument performance, test results, equivalence demonstrations and SOPs, and process them into specifi