RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Social Adaptation: When Software Gives Users a Voice' in the context of a Seventh Framework call.

assistant: **Objectives**

Adaptation is a desirable feature of software systems to respond autonomously to changes so that human’s time and effort are minimized. The ultimate goal is that users get their dynamic requirements met correctly and efficiently. Adaptation is triggered and guided by certain drivers such as context changes and quality assessment of its execution. Traditional adaptive systems engineering assumes a system ability to monitor adaptation triggers autonomously. This assumption, however, is not always possible due to limitation of technology and also to the lack of infrastructure needed to do that in certain uses of the system.Example: imagine a disaster management system which needs data about a flash flood to decide upon what rescue strategy to adopt. There could be no fully-automated way to monitor these data and, moreover, it could be impossible to monitor if an execution of a strategy was successful, i.e., impossible to monitor quality. The system will have to try a strategy assuming that it is correct, all that under a high degree of uncertainty.SOCIAD suggests that people are powerful monitors who can provide data which are essential for adaptation and unmonitorable by relying on solely automated means. This proposal will develop requirements engineering framework (theoretical principles, models, automated analysis mechanisms, CASE tools, and case studies) for modelling, gathering and using users’ feedback in order to guide software adaptation.Raian published SOCIAD idea as a New Ideas Track paper in FSE’11, a top software engineering conference, and a full paper in ENASE’12 conference winning the Best Paper Award.Raian moved to BU in Feb 2012 . He is still in the probation period with a high teaching and adminstrative load. This grant will enable Raian to remain active
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nanocrystals for CO2 Reduction', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Materials that efficiently and selectively catalyse the reduction of CO2(CO2RR) into chemical feedstocks would open the path to a sustainable zero-emission energy conversion cycle in the making of fuels and base chemicals. Colloidal techniques demonstrated as impactful in the synthesis of metallic nanocrystals (NCs) presenting optimal selectivity towards energy dense products, ideal for energy storage. The challenges in rationalizing NCs synthesis pathway, stability in-operando, and the CO2RR mechanism they catalyse thus present a great reward.To promote the synthesis of efficient and stable colloidal NCs for CO2RR, NanoCO2RE will encompass the study of all NCs life-stages by means of systematic in-silico investigations probing:1) NCs application as catalysts, by screening the selectivity and activity of a large number of non equivalent adsorption sites that catalyse CO2RR, to identify the ideal ones to be engineered in a high-performance NC.2) NCs eventual degradation in-operando, by sampling structural rearrangement in NCs presenting different size, shape, composition under reaction conditions, to single out suitable designs preventing detrimental NC restructuring.3) NCs growth pathways, to establish NCs programmable synthesis route as a function of tunable parameters (precursors, temperature, reagents).NanoCO2RE will exploit the combination of electronic structure, enhanced sampling, and big-data techniques to encode the necessary realistic complexity and predictive accuracy, and in turn to establish rational design criteria in the synthesis of stable and selective nanocatalysts for CO2RR. Beyond the use of state-of-the-art numerical tool, a strong interdisciplinary approach is at the grounds of the project: in-silico investigations will be synergically paralleled by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Stereoselective Fe- and Co-catalyzed Oxidation and Peroxidation of Hydrocarbons' under Sixth Framework.

assistant: **Concept**

Selective catalytic oxidations of organic molecules are among the most important industrial chemical processes. Chemical raw materials are principally hydrocarbons which are the product of petrochemical production. Due to their inert nature, their selective functionalization is a key objective of research in academia and industry. The aim of the project is the development of a novel class of homogeneous oxidation catalysts which are effective in the stereo-selective allylic oxidation of alkenes. In contrast to the majority of the previously studied copper complexes, these will be iron (and cobalt) based. Beyond the narrower goals of the proposed research, they provide the potential access to catalytic systems for the controlled oxidation of prochiral alkanes. The key to the practical implementation of the research program is the development of two novel classes of meridianally coordinating chiral ligands which are potentially suitable for enantio-selective transformations. The approach combines design- and diversity-driven elements and the efficiency of the iron catalysts will be tested with respect to a number of standard reactions which allow the comparison with previously reported chiral catalysts. High throughput analytical methods are will be extensively used in the optimization of catalyst performance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Selective separation of strategic and precious metals' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Strategic and precious metals (SPMs) are being increasingly used in new products e.g. homogeneous catalysts; pharmaceuticals etc. Recycling of precious metals has traditionally been performed using pyrometallurgical techniques which are very energy intensive; or hydrometallurgical techniques which involve strong chemicals. These techniques, however, are limited because they do not provide the degree of separation required. Further refining is then required. This proposal suggests a bioelectrochemical technique which is capable of selectively recovering the key precious metals e.g. Pt , Pd, Ru and Rh. The process could be operated to produce zero waste. The recovered metals will be of high purity enabling a recycling of scrap to fine chemicals in one clean and efficient process. It is estimated that there are currently 20 tonnes/year of precious metals in spent autocatalysts alone providing a key market for this technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of new environmentally acceptable lubricants, tribological tests and models for european sheet forming industry' (ENLUB), addressing dissemination and exploitation.

assistant: **Impact**

The European sheet forming industries are facing considerable problems due to legal requirements of introducing environmentally acceptable lubricants as substitutes for the present hazardous/toxic ones. The objectives of this project are to develop new environmentally acceptable lubricants and an approach for prediction or prevention of lubricant film breakdown in sheet forming operations to facilitate a shift in the European industry towards environmentally acceptable lubricants. These objectives will be achieved by developing new environmentally acceptable lubricants based on pine oils and dry-film polymers, a system of experimental tests for sheet forming tribology combined with numerical modelling of lubricant film breakdown, which are integrated into a design support system. The expected output are new lubricants and a combined experimental and theoretical approach for prediction or prevention of lubricant film breakdown.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innate sensing of HIV and immune responses' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Since its isolation in 1983 as a causative agent of AIDS, HIV-1 has remained an exceptional challenge. The human immune system usually ultimately fails at controlling infection by the virus. In contrast, most individuals infected with the related and poorly studied lentivirus HIV-2 do not develop AIDS. The immune response is clearly implicated in this protection, but the mechanisms are not well understood. DCs are a unique type of immune cell that sense pathogens and couple this sensing to the activation of innate and adaptive immunity. We have recently discovered that unlike HIV-1, HIV-2 is sensed in dendritic cells (DCs), a finding that is strikingly parallel to the in vivo situation. We found that sensing of the virus in DCs in vitro induces an antiviral innate response and activation of CD4+ and CD8+ T cells. Whether this adaptive response contributes to the lack of AIDS pathology in HIV-2 infected patients is unknown. Therefore, while the vast majorities of studies have focused on HIV-1, we believe that the HIV-2 represents a unique opportunity to discover how HIV-sensing in DCs translates into protective immune responses. To address this question, we propose an approach at the interface of immunology and virology. We propose to:1) Unravel the type of CD4+ and CD8+ T cell responses induced by DCs that sense HIV-2. We will examine how naïve T cells respond to HIV-2 in vitro and how this compares with the response of memory T cells isolated from HIV-2 infected patients who control their virus.2) Determine what is sensed by DCs in HIV-2.3) Identify cellular regulators of HIV sensing in DCs.Altogether, this study will integrate molecular sensing of the virus and adaptive immunity to provide an understanding of how the immune response against HIV-2 operates. We believe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European randomised multicentre trial on risk-adapted adjuvant chemotherapy in node-negative breast cancer based on selection by tumorbiological prognostic factors' in the context of a Fourth Framework call.

assistant: **Objectives**

Objectives:? Improved effectiveness of systemic adjuvant treatment in node-ne gative breast cancer patients by identification of patients at high risk for rel apse using the tumorbiological factors uPA (urokinase-type plasminogen activator ) and its inhibitor PAI-1.? Confirmation and validation of the prognostic an d predictive significance of uPA/PAI-1 for breast cancer.? Feasibility of a pplication to breast cancer patients in daily practicBrief descriptionOptimal treatment of breast cancer patients represents a majo r clinical and health problem with a high socio-economic impact. Strong recommen dations (consensus") were given to offer all patients some kind of adjuvant the rapy. Nevertheless, adjuvant therapy in patients with tumor-free axillary lympho nodes remains a matter of debate, as about 70 % of these patients are cured by s urgery alone. Unselected treatment would lead to an overtreatment in the vast ma jority of these patients. Therefore, high-risk patients should be selected for a djuvant therapy by validated prognostic factors.Recent basic and clinical canc er research performed at the European level (see BIOMED-I Program: BMHI CT 93-13 46) demonstrated the key role of the tumor-associated protease urokinase-type pl asminogen activator (uPA) and its inhibitor PAI-1 in these processes. The uPA an d PAI- 1 contents of breast cancer tissue are shown to be the strongest independ ent prognostic factors in node-negative disease.To promote transfer of these recent results derived from basic research into gen eral clinical practice a randomized clinical trial is mandatory. In this trial, node-negative patients with high values of uPA and/or PAI-1 should be randomized to adjuvant chemotherapy (6 cycles CMF) versus observation. Patients with low c ontent of both uP
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Conservation Restoration Innovation Systems for image capture and digital Archiving to enhance Training, Education and lifelong Learning' under Fifth Framework.

assistant: **Concept**

The project will develop equipment for the direct fast capture of paintings, with a new ultra-high definition multi-spectral scanner (ultraviolet to infrared) with a homogeneous lighting system. Software will be developed that uses a new colour chart and illumination correction to calibrated multi-spectral images. Research will be conducted into spectrometric analysis of varnish layers to allow the effect of an aged varnish to be substracted from an image of a painting. Large format, colour-accurate prints will assist in the restoration of paintings and be of use in exhibitions as surrogates for fragile works of art. Studies will be made of the long-term durability of storage media and of archiving techniques. A bi-lingual electronic handbook will be published on the web. Paintings will be captured, archived for long-term preservation, electronically restored, printed for exhibition and used for demonstration purposes.Objectives:The objectives are to develop a technology and information environment to preserve paintings by ultra-high quality multispectral digitisation, to preserve as well the created digital resources in long terms, and to enable the use of the images as surrogates and to assist conservation of the originals.This includes: digitisation technology, colour calibration, software to determine the original paint colour beneath aged varnish from multispectral imagery, colour-accurate printing and long-term durability of storage media. An inventory system for these resources will be developed for timely replacement of over-aged data carriers, monitoring and planning of distribution, recovery strategies from losses and as index for conservators. An integrated, interactive, dynamic electronic handbook will convey the complex knowledge to use these imaging techni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Breakthrough dual-action OTC tablet for treatment and prevention of both bacterial and fungal vaginitis' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

There is a large unmet medical need for an efficient and highly accessible solution that can simultaneously treat and prevent BV and VVC, while removing the abuse of antibiotic and antimycotic drugs to avoid further antimicrobial resistance. The inefficacy of current solutions is demonstrated by the huge burden that BV/VCC bring to the society in terms of economic expenses (more than 3.8Bn annually), preterm births (5.4M per year), the huge prevalence of both diseases (more than 500M cases per year) and the deteriorated QoL for women. Gedea has developed pHyph, a patented pessary that due to its safe profile will be highly accessible as a first line OTC solution. pHyph is an antimicrobial-free dual solution with a new mode of action that targets both the treatment and prevention of BV and VVC, without the need of pathogen identification. pHyph will be commercialized as an OTC product in pharmacies and drug stores  where 90% of women with VI look for a treatment to the infection. The business model targeted for pHyph is a well-established and successful B2B2C model for this type of product. Our business model is highly scalable via planned partnerships with distributors and pharma companies, that will facilitate accelerated commercial deployment & scale up of our business throughout Europe & beyond.  Gedea core team is composed by 9 persons with over 250 years of experience combined, including experts in clinical research, bioorganic chemistry, regulatory affairs, marketing, and business development. The company received the award ""Rapidus Company of the Year"" and appeared on Labiotech's list ""The 20 European Biotech Companies to Watch in 2022"".During this project, Gedea will perform the necessary clinical trials, CE-Mark Certification and pre-market activities to co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'High-density QCD matter from first principles'.

assistant: **Innovation**

Predicting the collective properties of strongly interacting matter at the highest densities reached within the present-day Universe is one of the most prominent challenges in modern nuclear theory. It is motivated by the desire to map out the complicated phase diagram of the theory, and perhaps even more importantly by the mystery surrounding the inner structure of neutron stars. The task is, however, severely complicated by the notorious Sign Problem of lattice QCD, due to which no nonperturbative first principles methods are available for tackling it. The proposal at hand approaches the strong interaction challenge using a first principles toolbox containing most importantly the machinery of modern resummed perturbation theory and effective field theory. Our main technical goal is to determine three new orders in the weak coupling expansion of the Equation of State (EoS) of unpaired zero-temperature quark matter. Alongside this effort, we will investigate the derivation of a new type of effective description for cold and dense QCD, allowing us to include to the EoS contributions from quark pairing more accurately than what is possible at present. The highlight result of our work will be the derivation of the most accurate neutron star matter EoS to date, which will be obtained by combining insights from our work with those originating from the Chiral Effective Theory of nuclear interactions. We anticipate being able to reduce the current uncertainty in the EoS by nearly a factor of two, which will convert into a precise prediction for the Mass-Radius relation of the stars. This will be a milestone result in nuclear astrophysics, and in combination with emerging observational data on stellar masses and radii will contribute to solving one of the most intriguing puzzle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Development of a heat pump free of cfc's with high efficiency for heatingand air-conditioning of buildings on the basis of a combined Absorption/ Compression Process'.

assistant: **Objectives**

The aim of this project lies in the development and testing of an emissionfree heat pump for the provision of cold or heat for the air-conditioning of buildings (e.g. hotels, hospitals, shopping centres and public buildings). Principle characteristic of the process is absorption under low pressures. For cooling purposes, triple point conditions are set at which the three phases ice, water and steam coexist. An ice suspension is produced as a result which can be used for air-conditioning. In the case of heating, the pressure in the absorber is raised slightly and the absorption heat produced is used for heating. The objective of the project lies in the compilation of design documents and analysis of the behaviour in operation of a plant on an experimental pilot scale with a refrigeration capacity of 40 kW and a heat flow of 50 kW in accordance with the principle of the process described. A COP of 6,5 in refrigeration mode (cooling water temperature of 25 C) will be achieved. Furthermore, the use of compact apparatus freezer, desorber) with integrated enhanced heat and mass transfer surfaces should be investigated in order to optimize investment costs. The technical objectives contain in particular: - System integration possibilities for the Mediterranean area - Investigation of the capacity range (heating and cooling) for buildings - Development of a computer programme for the simulation of the entire process Analysis of permissible load and part load behaviour - Ice transport, ice separation and selection of suitable components (ice content, diameter, etc.) Absorption at low pressures (6 mbar) - Investigation of heat and mass transfer on enhanced surfaces for compact apparatus Evaporation and ice formation on the droplets (retention time and droplet spectrum) For coolin