RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mechanisms of chromosome segregation in mammalian oocytes' (CHROMOOCYTE).

assistant: **Innovation**

All animal life starts with the fertilization of an egg. A haploid egg and a haploid sperm fuse and together they form a new genetically unique embryo. But surprisingly, eggs frequently contain an incorrect number of chromosomes. Depending on the age of the woman, 10-50% of eggs are chromosomally abnormal. This high percentage of abnormal eggs results from chromosome segregation errors during oocyte maturation, the process by which a diploid oocyte matures into a haploid egg. Thus, errors during meiosis in human oocytes are the most common cause of pregnancy losses and contribute to approximately 95% of human aneuploidy such as Down’s syndrome. Surprisingly, we still know very little about how mammalian oocytes mature into eggs, and it is still unclear why chromosome segregation during meiosis is so much more error-prone than during mitosis.My proposal combines three innovative and complementary approaches towards understanding how homologous chromosomes are segregated and why oocyte maturation in mammals is so error-prone. Specifically, we will work towards the following three aims: 1. We will complete the first large scale screen for genes required for accurate progression through meiosis in mammalian oocytes and characterize the function of a few selected genes in detail. 2. We will analyse meiosis and investigate potential causes of chromosome segregation errors directly in live human oocytes. 3. We will study the function of an F-actin spindle and a chromosome-associated myosin that might be required for chromosome segregation in mammalian oocytes.Because errors during oocyte maturation lead to pregnancy loss, birth defects and infertility, this work will not only provide important insights into fundamental cellular mechanisms, but will also have important implicat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enhancing transport in open magnon systems', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

There is a great need for new energy-efficient technologies to meet the ever-increasing energy demands of the 21st century. The field of magnonics aims to address this need by developing nanoscale magnonic devices that use magnons - the excitations of magnetic materials - as information carriers. Because magnons do not require electric currents, they are much more energy efficient than electron-based technologies. However, the transport of magnon signals over long distances remains a key challenge, limiting the development of a mature magnonics platform. The central objective of the OpenMag project is to meet this challenge by harnessing the coupling of magnons to their environment. This renders the magnon transport non-Hermitian, opening up pathways to engineer the enhancement of magnon transport. OpenMag will thus open up the field of non-Hermitian spintronics: the study of the spin degree of freedom in non-Hermitian systems. This will be accomplished through two strategies: (1) the interaction of magnons with photons in a cavity and (2) the development of non-Hermitian magnon topological phases through magnon-electron interactions. These strategies will initially be developed in ferromagnets, which allows OpenMag to make use of their well-understood magnetization dynamics. Using insights from ferromagnetic materials, OpenMag will develop non-Hermitian spintronics in antiferromagnets and altermagnets, which will enable access to fast dynamics and downsizing to the nanoscale: two crucial milestones in magnonics.The OpenMag project will be carried out at the Johannes Gutenberg University (JGU) Mainz, under supervision of Prof. Sinova, who leads a world-renowned theory group in spintronics and nanoelectronics. Over the past decades his group has developed the theoretical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A novel vaccine technology leading to accelerated availability of vaccines and improved delivery'.

assistant: **Objectives**

Common to current manufacturing technologies for vaccines is the long lead-time before they were made available or novel vaccines could be made available to the public. Current methods are very time consuming and frequently encounter problems with scale-up, in particular if sudden demands have to be met. However, the ability to start vaccination campaigns fast – and earlier than currently possible – is particularly important in view of seasonal influenza, influenza pandemics or sudden outbreaks of dangerous, hereto unknown infectious diseases. Resulting delays definitely pose a high risk for health and lives of many people. To provide solutions to these world-wide challenges is of European and global interest and GZA offers such a response:The technology is based on self-assembly of SV40 capsid proteins around a given nucleic acid and has several additional applications; however, it will be validated here in the area of vaccination with RNA. The main advantage of GZA’s novel vaccine technology platform is that it enables strongly shortened manufacturing periods and accelerated market introduction of a novel vaccine (e.g., 2-3 times faster manufacturing for novel influenza vaccines). The business model is based on developing and validating the technology for a given purpose in-house and receive milestone payments and royalties specified in co-development and licensing agreements with established pharma companies active in the vaccine sector (such as GSK, Novartis or Sanofi Pasteur).Most importantly, in the feasibility assessment applied for here GZA wishes to further detail the business plan with updated evaluations of markets, competitors, IP, a project/development plan and budget to further highlight the attractiveness of the business case and to prepare initiation of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Researching alternatives to fish oil for aquaculture' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

OBJECTIVES AND EXPECTED ACHIEVEMENTSThe overall aims of the project are:(a), to replace as much as possible of the fish oil currently used in farmed fish feeds with vegetable oils, without significantly compromising the health and welfare and growth performance of the fish, or its health promoting, taste and other acceptability characteristics to the consumer and processor;(b), to under pin the findings by advancing current understanding of fish lipid nutrition. Atlantic salmon, trout, sea bream and sea bass will be fed diets containing various blends of fish oil and vegetable oils including linseed oil, rapeseed oil and olive oil over the effective life spans of the species, namely from first feeding until the fish reach market size.The specific Objectives and Achievements of the programme, listed below, will collectively enable the project to attain its stated aims.OBJECTIVE 1:to analyse feed intake, growth and utilisation of nutrients and energy in the species.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Learning from Bats: New Strategies to Extend Healthspan and Improve Disease Resistance' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The medical, financial, and emotional costs imposed by ageing and infectious diseases are major challenges for our societies. Strikingly, while past research has not provided solutions for extending human healthspan and preventing the harmful consequences of infections, nature has solved both problems in the only flying mammals – the bats. Among mammals, bats exhibit an exceptional longevity with little signs of age-related diseases. Despite being reservoirs for numerous deadly viruses, viral infections in bats are mostly asymptomatic due to unique immune system adaptations. The overarching goal of BATPROTECT is to achieve breakthroughs in our understanding of the molecular basis of bats’ extended healthspan and disease resistance to ultimately discover new directions to improve human healthspan and disease outcome. BATPROTECT integrates a team of world-leading experts in bat biology, genomics, immunology and gerontology to synergistically: (i) elucidate the molecular mechanisms that bats use to slow down expected ageing; (ii) identify the driving molecular mechanisms behind bats’ viral tolerance and limited age-related inflammation; (iii) uncover the genomic basis and evolution of extended healthspan and disease tolerance in bats; and, (iv) develop transgenic animal models to functionally validate the uncovered bat adaptations. We will generate 150 reference quality bat genomes, the novel immunological, bioinformatic, cellular and molecular tools required to take an integrative multi-omics approach and uncover the age and immune changes that occur in wild and captive bats across the ageing spectrum. We will identify the top regulators of longevity and immunity, using deep neural networks analyses, to functionally validate in our cellular systems and novel transgenic an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'STRUCTURAL GENOMICS: FROM GENE TO STRUCTURE TO FUNCTION' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Structural Genomics will be crucial in the post-Genome sequencing era. It aims to add value to the wealth of data produced by the Human Genome Project (and those from other organisms) by providing a three-dimensional picture of what the proteins produced by genes do in a biological context. It is an inter-disciplinary subject, ranging from the physics of X-ray diffraction or NMR Spectroscopy to the Molecular Biology and Biochemistry of genes and proteins, with Bioinformatics and Computational Biology involved at almost every stage.Protein structure is central to all aspects of molecular biology and disease. Structural Genomics will have a major impact on Academic and Industrial Research. Results will both add greatly to the understanding of biological processes and aid the design of novel therapeutic agents.Large Structural Genomics projects are currently underway in the US and Japan. However, there is limited activity within Europe. This meeting will bring European scientists together with researchers involved in the large-scale projects in the USA/ Japan with a view to applying greater focus to Structural Genomics within Europe. The meeting will comprise eight sessions. The Target Selection session will focus on the order in which genes are to be studied by Structural Genomics. A session on Expression, Purification & Crystallisation will deal with key areas of Molecular Biology and Biochemistry that are upstream of the experimental Structural Biology experiments. Three sessions on Structure Determination will address current efforts within Europe and the rest of the world, with respect to new technological developments and results from current projects. A session on Functional Genomics will address experiments, which complement Structural Genomics. Two further session
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Clinical safety, immunogenicity and efficacy of a therapeutic vaccine that combines peptides mimicking antigen receptors on autoimmune B and T cells associated with myasthenia gravis'.

assistant: **Innovation**

The MYASTERIX project will advance a therapeutic vaccine candidate (designated orphan drug) indicated for the autoimmune disease myasthenia gravis (MG) to clinical proof of concept studies. MG is caused by T cell dependent antibodies that bind to and deplete acetylcholine receptors (AChR) at neuromuscular junctions causing muscle weakness by interfering with neuromuscular transmission and junction architecture. The vaccine candidate comprises two synthetic peptides designed to generate antibodies that bind to autoantibodies and T-cell receptors associated with MG. These peptides prevented or improved muscle fatigue in a rat model of MG and increased the remission rate to 75% in pet dogs (compared to 17% natural remission rate in historical controls). In both models, administration of the peptides resulted in reduced titres of anti-AChR antibodies and lower numbers of anti-AChR T-cells, based on the induction of antibodies that bound to the corresponding B and T cell antigen receptors. These results suggest that similar antigen receptor mimetic vaccination approaches could drive autoimmune diseases like MG into long-term remission.The objectives of the project are to manufacture toxicology and clinical batches of the vaccine human formulation based on already developed and tested standard operating procedures, to carry out stability and regulatory toxicity testing of the GMP product, to conduct phase I and subsequently phase II clinical trials to demonstrate safety, tolerability and proof of mechanism of action/concept of the therapeutic vaccine.The impact on MG patients will be to offer a targeted therapeutic approach requiring only three injections, bringing significant and lasting improvement or even a cure. MG is a model for many autoimmune diseases and the concept o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Frontiers in invasive species distribution modelling: incorporating human-associations and intraspecific niche structure to improve risk predictions.'.

assistant: **Concept**

Biological invasions represent a major component of global change through their impacts on biodiversity, ecosystems and societies. Awareness of biological invasion impacts and the critical importance of evidence-based decision making have led to a persistent effort to understand the factors driving invasion success so as to be able to predict invasion outcomes. To this end, a range of modelling tools has been developed. Among them, species distribution models (SDMs) -phenomenological models that statistically relate observed species occurrences to environmental variables- play a critical role in invasion risk assessments. These models rely on ecological niche theory, which predicts that for recent events such as biological invasions, conservatism of the climatic niche is expected. However, recent studies have demonstrated that this approach could be hampered by apparent niche shifts in invasive ranges. Mismatches between native and invasive distributions derived from SDMs have been often interpreted as species adaptations in response to selection pressures in novel environments. However, methodological drawbacks of previous approaches fuel doubts about the biological meaning of these findings.  In this project, two unresolved challenges faced by SDMs when applied to the biological invasion process will be examined: how (1) species’ association with human-modified habitats in native ranges and (2) intraspecific niche variation shape the distribution of invasive species at biogeographical scales and how these effects influence the reliability of predictions of invasion risk. To accomplish these goals, I will use an interdisciplinary approach combining global bird distribution data, with molecular phylogenetic data and modern statistical and ecological analyses. The result
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Simultaneous MRI and EEG measurement of brain function integrated within a single instrument' (1994-1998).

assistant: **Innovation**

There is much interest, including from the EC, to the unravelling of human brain activity. Several clinical groups are already involved with correlating data obtained with EEG (electroencephalography), MRI (Magnetic-Resonance Imaging), and even PET and CT in order to obtain a more complete view on human brain functioning. A step further would be to simultaneously measure EEG and MRI to enable an interaction and a temporal correlation between the two measurements. The innovative objective of this project will be to develop a MRI-EEG scanner which enables the clinician to measure simultaneous details by functional MRI and the global brain activity by EEG. Also a close handshaking procedure between both EEG and MRI is foreseen in order to enable a precise timing and triggering. The instrument will be provided with removable and completely non invasive EEG electrodes to enable its use for human brain studies. This ensures not only a narrow interaction between the two data sets but also opens possibilities of triggering MR imaging sequences by specific signals from the EEG. Although the final objective is to trigger the development of MRI-EEG instruments for human applications, it is obvious that, for reasons of security, repetitivity and economy, the suggested research is performed on animals. However this will provide sufficient evidence to ensure the successful implementation on clinical systems. This new generation of clinical MRI systems represents a powerful tool for neurologists, and ensures the competitive position of European MRI instruments on the world market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Atmospheric blocking under global warming - sources of uncertainty in climate predictions and projections.' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Cold spells, heatwaves and droughts have severe socio-economic impacts and are related to a peculiar phenomenon known as ‘atmospheric blocking’. Accurate and timely prediction of blocking frequency and strength is therefore of enormous importance. However, despite decades of research, climate models still exhibit substantial errors in blocking, leading to large uncertainties in seasonal-to-decadal predictions and future projections of blocking trends. At the root of this is the lack of a fundamental theory for blocking and an appropriate metric to identify blocks. A recent theoretical breakthrough offers an exciting path forward by drawing an analogy between blocking in the atmosphere to traffic jams on a highway. The traffic jam – blocking theory, which is based on the conservation properties of large-amplitude nonlinear waves, has led to a conceptual simplification of why blocks occur. Leveraging the promise shown by this new theory, ATM BLOCKING will provide the first-ever assessment of the key dynamical drivers of blocking errors and trends in the state-of-the-art global climate models. The success of ATM BLOCKING will offer a new theoretical basis for evaluating the performance of climate models in simulating blocks, with an unprecedented ability to pinpoint the responsible atmospheric processes across timescales.  Down the road, these results will help policy makers and stakeholders to prepare for risks associated with climate change and weather extremes. The project proposes to address the problem using a combination of theory, numerical modeling and statistical analysis at University of Bergen, Norway in close collaboration with the Bjerknes Centre for Climate Research under the supervision of leading experts in climate dynamics, climate modeling and weather ext