RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Upgrading geomaterials: from waste to resource'.

assistant: **Concept**

UPGRADE seeks to broaden the research scope of the involved teams, focusing on tackling key challenges in geotechnical and geoenvironmental engineering. Specifically, it aims to pioneer innovative solutions for repurposing waste geomaterials generated by construction and mining industries worldwide. Waste geomaterials represents half of the waste volume generated in EU. These waste geomaterials generally exhibit poor engineering characteristics that prevent their direct use at construction/mining sites. However, if adequately treated, they could represent an excellent resource for construction purposes with significant money saving and reduction in the environmental footprint, thus contributing to the establishment of a circular handling/management of geomaterials. To achieve this, UPGRADE will develop protocols, software and tools to improve the engineering characteristics of waste geomaterials, and to guarantee the performance level over the service life of geostructures built from waste geomaterials considering site-specific conditions. The fundamental concern of UPGRADE is to promote strategies for sustainable use of waste geomaterials generated by geoengineering activities, and to determine how to turn a waste geomaterial into a durable material, with a positive revenue stream.  The originality of UPGRADE's approach is that not only it draws expertise on the environment and geotechnics, but also in computer sciences, geochemistry, analytical chemistry, natural resources exploitation, and in the circulatory economy. We intend to form a multidisciplinary consortium composed of 10 academic and 5 industrial beneficiaries and 6 Third Country partners which aim to address this problem. UPGRADE will create an international, interdisciplinary and intersectoral network of c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Overcoming specific weaknesses in tendon biology to design advanced regenerative therapies' to be submitted under Horizon 2020.

assistant: **Abstract**

The main goal of Achilles is to significantly strengthen the science and technology capacity of UMinho in biophysics, cell/molecular biology and genetics/gene therapy in order to achieve global scientific excellence and competitiveness for the translation of advanced therapies/ tendon tissue engineering strategies to treat tendon injuries/diseases; At the same tine, Achilles also aims at positioning the research profile of UMinho and its staff in an outstanding international research level. This will be achieved by establishing a twinning process through knowledge sharing and collaboration between 3B’s Research Group of University of Minho (UMinho) and 2 internationally leading institutions: Department of Trauma Surgery of the University Regensburg Medical Centre (UHREG) and the Regenerative, Modular & Developmental Engineering Laboratory of the National University of Ireland Galway (NUIG). Achilles will focus in defined areas in which UMinho shows a less scientific knowledge and are well-complemented by UHREG and NUIG. The project objectives are:- To significantly increase the scientific excellence in tendon tissue engineering and reinforce human resources profile of UMinho;- To significantly increase the international visibility of UMinho and unleash its networking gaps with international outstanding R&D organisations;- To create strong links between UMinho-UHREG-NUIG allowing a constant and sustained knowledge sharing and research collaboration network which will continue sustainably in the long-term;- To significantly increase the capacity of UMinho to translate excellent scientific production into new therapeutic approaches for the treatment of tendon disorders and in providing high-quality services and consulting, improved capability to compete for funding as well
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Semi-active passive control of the dynamic behaviour of structures subjected to earthquake, wind and vibration' (SPACE) targeting Fifth Framework.

assistant: **Abstract**

Problems to be solvedThe proper functioning of industrial equipment and provision of safe working environment require techniques to reduce the effects of earthquakes, wind and traffic-induced vibrations on structures. Present technologies applied - isolation and passive energy dissipation - have limitations. The aim of this project is the development of innovative systems for reducing the effects of seismic induced vibrations. Based on the performance needs of various types of structures & industrial plants, selected in the project, such innovative devices will be designed, manufactured and tested.Scientific objectives and approachThe objectives of the project are to develop:1)semi-active vibration control system using hydraulic dampers based on magneto-rheological smart fluid;2) floor isolation system operating in 3 directions;3) 3D floor isolation system incorporating the semi-active dampers developed. Prototype devices will be developed, manufactured and widely tested also incorporated in mock-up structures.The project will consist in the following phases:- Definition of structures for the application of semi-active and passive devices- Development of semi-active control system- Numerical models of the devices, of the structures and mock-ups and dynamic analyse-Characterisation tests of devices, structures and mock-ups- Evaluation of technical and economical benefits- User Manual (design procedures for the implementation of the semi-active control and for passive technologies).Expected impactsThe protection of transport infrastructure, industrial plants and strategic buildings from earthquake damage is of paramount importance, particularly to Southern areas of the European Union. Countries situated in earthquake-prone areas, for instance California (USA), Japan and N
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ab initio calculation of the crystal field in r(fe1-xmx)12 compounds' to be submitted under Fourth Framework.

assistant: **Abstract**

The goal of the proposed work is to apply the novel ab initio calculation method and to critically test its suitability for the problem of the crystal field interaction in 3d-4f intermetallics, which provides the clue to magnetic anisotropy and coercivity of modern permanent magnet materials. With this end in view, it is proposed to carry out self-consistent spin-polarised calculations of the electronic structure and the rare-earth crystal field parameters of an important family of permanent magnet materials, R(Fe1-xMx)l2, where R=rare earth, M=V,Ti,Mo. On the basis of the thus obtained crystal field parameters, it is proposed to calculate the macroscopic magnetic anisotropy of the compounds concerned, including, where applicable, spin-reorientation transition points and temperature dependence of the canting angle. It is further proposed to calculate local magnetic moments as well as hyperfine fields and electric field gradients on the iron sites. The results of these calculations will be compared directly with experimental data available in literature.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Impact of maternal Adrenomedullin on the Microbiome and Gut health: insights into preventing chronic intestinal disorders' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal inflammation that has become a global disease with a high economic burden. Adrenomedullin (AM), a hormone associated with gut microbiota and physiology, is naturally present at high concentrations in maternal milk and during lactation. Using a conditional model for AM the fellow identified a protective role of endogenous AM in IBD onset, however relatively little is known about its exact role in early-life, in colitis development or as a potential diagnostic tool for IBD. The fellow hypothesizes that maternal AM’s impact on the breast and gut microbiome may regulate gut and immune development and colitis susceptibility. By creating the first mammary gland conditional knock out for AM, she will uncover novel disease mechanisms and provide the basis for new diagnostic and prevention strategies for IBD. The final goals of this multi-disciplinary project are 1) to unravel the impact of AM on the breast microbiome, the maternal AM influence on healthy infant gut development and the prevention of colitis; 2) to reveal the impact that nutritional intervention and AM administration have on milk and gut microbiome to compensate for dysbiosis and in preventing colitis progression; 3) to evaluate the value of AM as an independent prognostic biomarker for IBD. The project has been carefully designed to match the fellow’s expertise in generating transgenic mice, AM biology and molecular techniques; the expertise of the host institution (APC Microbiome Ireland) in next generation sequencing, cell culture models (organoids), flow cytometry and human studies; and the expertise of the secondment supervisor (UCD) in in situ hybrisation and digital pathology technology. Plans to improve the fellow’s ability to disseminate rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'UpstreaM synergIes to overcome Locked-in effects in widEning regions and broaden internationalization pathwayS for susTainable innOvatioN and compEtitive grant applications' (MILESTONE).

assistant: **Concept**

MILESTONE will attempt to establish strong collaboration links among three widening academic institutes from Greece (UPAT), Slovenia (NIC), and Czech Republic (MU), as well as with an advanced partner (AMU, FR), to overcome locked-in institutional effects, build synergies and create a pathway to excellence, producing new knowledge in antiviral research and pandemic preparedness. UPAT, NIC, and MU, all acknowledged national/regional research actors funded by ERDF, share common interests in biosciences and will collaborate with a world-class expert in biochemistry, virology, and infrastructure management, the AMU.The MILESTONE strategy seeks to internationalise widening partners to boost their access to EU R&I consortia in joint applications under Pillars I & II, as well as to unlock, reinforce, and improve the utilization of existing R&I capacity. A key project module is training, knowledge sharing, and the acquisition of transferable skills for R&I personnel to increase performance in research, research management, fund-raising, and communication.MILESTONE’s implementation is based on well-designed WPs with specific tasks and roles for each partner to have a large impact at the scientific, societal, and economic/technological levels, and to increase the competitiveness and reputation of all partners in the direction of future sustainable development.Furthermore, MILESTONE is guided by the principles of gender equality, open research and data management. Project progress will be communicated to all prospective stakeholders as well as the public through e-communication channels and live events.Overall, MILESTONE aims to establish an effective collaborative network among participating partners to achieve synergies between Horizon Europe and  cohesion policy programmes (ERD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Alternate Transcript Diversity Project' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Production of mature mRNA transcripts in vertebrates is regulated at three stages: transcription initiation, splicing and polyadenylation. The combinatorial arrangement of variations at each stage generates, from a single gene, a variety of mRNA isoforms with different start sites, exons or 3' UTRs. Expression of Alternative Transcripts (AT) has been observed to be specific to tissue-type or developmental stage. Disruptions in expression patterns have serious consequences for an organism and are associated with numerous diseases, including cancer, multiple sclerosis, heart failure and neurodegenerative disorders. Identifying disease-specific AT's can lead to development of novel drug targets or markers. European bioinformatics laboratories have contributed to identification of variants of transcript start site, of splicing, and of polyadenylation sites. Our objective here is to develop and integrate these independent approaches in order to derive a unified view of AT formation and create a genome-scale reference database for human AT; such a data is envisaged to include alternate transcript structures, functional consequences of variations, phylogenetic conservation, and references to other major genome and proteome resources. In addition, we will seek to identify tissue- or disease-specificity of isoforms using bioinformatics approaches. This will potentially reveal co-regulated expression patterns and associated regulatory motifs involved in transcript maturation. Finally, a selection of alternative transcripts will be submitted to experimental validation using semi-quantitative RT-PCR.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PathsToDormancy: Identifying dormancy pathways for selective targeting' in the context of a Horizon Europe call.

assistant: **Objectives**

The survival and propagation of species fundamentally depend on the precise regulation of cellular growth and dormancy. This balance is crucial across various biological processes including reproduction, regeneration, and repair, where mechanisms such as embryonic diapause allow organisms to endure adverse conditions by temporarily halting development. During this dormant state, embryonic cells undergo significant rewiring of their transcriptional, epigenetic, and metabolic pathways, preserving their stem cell characteristics and enabling reactivation under more favorable conditions. Despite its essential role, dormancy presents challenges in cancer treatment. Cancer cells exploit conserved dormancy pathways to evade therapies, resulting in drug-tolerant persister (DTP) cells that can survive treatment, potentially leading to relapse with more aggressive and metastatic tumors. This phenomenon undermines efforts to combat cancer, as detecting and targeting dormant cancer cells remains a significant obstacle. Here we will leverage our in vitro dormancy culture systems identify regulators of cancer dormancy with embryonic origin.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'COMPUTER SIMULATIONS OF OPTICAL AND TRANSPORT PHENOMENA IN CARBON NANOTUBES' to be submitted under Seventh Framework.

assistant: **Abstract**

The growing realisation of the immense potential for applications of the carbon nanotubes has attracted much attention of scientists. Presently, the nanotube research has become one of the most intensively developing areas of nanotechnology. The principal reason for the amazing electronic and vibrational properties of the nanotubes stems in their quasi-one-dimensionality. The initially existing principal obstacle of normally very large nanotube unit cells, which hindered most of the atomistic simulations on perfect nanotubes, has recently been overcome by using of the screw symmetry of the nanotubes. This allowed for large-scale calculations of phonon dispersion and electronic structure, as well as various optical, thermal, and mechanic properties, of any nanotube of practical interest.  The principal objectives of this project are the extension of this symmetry-adapted approach to calculations of other properties and phenomena in nanotubes, which have not been addressed in detail so far. The major topics to be encompassed by the project are: 1) exciton effects, which are of major importance for the optical processes in nanotubes as evidenced by experiments and supported by theoretical arguments, 2) second-order Raman scattering, which can be a source of information for the electronic structure and phonon dispersion of nanotubes but has been described qualitatively only in several limited cases, 3) the phenomenon of photoluminescence, which provides direct information for the structural properties of carbon nanotubes and for the electron (or exciton) – phonon scattering processes, but has not received much attention by theorists, and finally, 4) thermal and electronic transport in nanotubes, which are basic phenomena with importance for building up nano-electronic devic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Symbiotic interactions at the origin of eukaryotes' to be submitted under Horizon Europe.

assistant: **Abstract**

Recent advances in environmental microbiology, metagenomics and phylogenomics strongly suggest that the eukaryotic cell evolved from symbiotic consortia involving an Asgard archaeon and, at least, the alphaproteobacterial ancestor of the mitochondrion. However, many genes of prokaryotic origin in the last eukaryotic common ancestor (LECA) appear to originate neither from archaea nor alphaproteobacteria, suggesting that other bacteria (e.g. Deltaproteobacteria) may have contributed to eukaryogenesis as additional symbionts or gene donors. To ascertain the origin of these genes, it is essential to better understand the ecology of symbiotic microbial consortia involving Asgard archaea (AA), and in particular, to identify the partners with which they interact in natural ecosystems. In this project, I will combine metagenomics, phylogenomics, fluorescence-activated single-cell/consortium sorting, high-throughput microfluidics, state-of-the-art fluorescence and electron microscopy techniques and cultivation approaches to identify and characterize members of AA syntrophic consortia and their associated viruses in a broad variety of microbial mats and oxygen-poor environments. With this information, I aim to i) identify the partners of AA syntrophic consortia across ecosystems, determine whether they co-evolve and unravel their ecological preferences; ii) characterize the metabolic interactions and phenotypic properties of AA symbiotic consortia in culture and/or from sorted consortia populations; iii) characterize the cell ultrastructure and potential presence of endomembranes in members of AA consortia, their three-dimensional organization and their spatial distribution in microbial mats; and iv) identify potential bacterial symbiotic partners involved in eukaryogenesis, in a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Making water governance effective (WAGE)' (WAGE) under Fifth Framework.

assistant: **Objectives**

The water crisis is mainly a crisis of governance stated the Global Water Partnership' s Framework for Action document presented at the second World Water Forum. The overall objective of the accompanying measure is at improve understanding of the challenges many African countries will face in implementing effective water governance at a local-level. The measure will complement and reinforce on-going and proposed initiatives by the EC and Member States. Close links with the GWP will ensure the outcomes of the measure are widely disseminated among a wide range water professionals and decision-makers.