RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'QUADRENNIAL OZONE SYMPOSIUM 2004'.

assistant: **Concept**

The project aims to support preparation and organisation of the next Quadrennial Ozone Symposium (QOS2004). This will be achieved through making local arrangements and providing support for young scientists and for scientists from accession countries to attend. A well-organised meeting is planned in which all current issues in stratospheric research are discussed. EU another countries are supporting substantial programmes of research on stratospheric ozone and related issues (UV) and it is important to ensure that maximum benefit is gained from this research. The relevance and innovative nature of future work will be promoted through the discussions between scientists from all over the world, enhancing also cooperation of EU with other international projects. The Symposium provides an excellent forum for researchers carrying out innovative work in the areas of field measurements, laboratory measurements, modelling and theoretical research in the ozone layer, which ensures that the latest findings will be widely discussed and disseminated. As such it will facilitate communication between researchers, in each area covered by the Symposium, so promoting exchange of knowledge, encourage scientific collaboration across the sub-disciplines of the field and world-wide, assist in the early identification of key concepts and questions and so help to direct resources and research towards the critical issues in the field. At the QOS2004 the discussions and presentations will include research on future stratospheric ozone levels affected by halogens, aerosols, water and greenhouse gas emissions and how physical, radioactive and chemical changes in the global stratosphere will be affected by climate change. Therefore, the Symposium falls within the objectives and the Work Programme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Drug addiction: molecular changes in reward and aversion circuits' under Seventh Framework.

assistant: **Concept**

Our affective and motivational state is important for our decisions, actions and quality of life. Many pathological conditions affect this state. For example, addictive drugs are hyperactivating the reward system and trigger a strong motivation for continued drug intake, whereas many somatic and psychiatric diseases lead to an aversive state, characterized by loss of motivation. I will study specific neural circuits and mechanisms underlying reward and aversion, and how pathological signaling in these systems can trigger relapse in drug addiction.Given the important role of the dopaminergic neurons in the midbrain for many aspects of reward signaling, I will study how synaptic plasticity in these cells, and in their target neurons in the striatum, contribute to relapse in drug seeking. I will also study the circuits underlying aversion. Little is known about these circuits, but my hypothesis is that an important component of aversion is signaled by a specific neuronal population in the brainstem parabrachial nucleus, projecting to the central amygdala. We will test this hypothesis and also determine how this aversion circuit contributes to the persistence of addiction and to relapse.To dissect this complicated system, I am developing new genetic methods for manipulating and visualizing specific functional circuits in the mouse brain. My unique combination of state-of-the-art competence in transgenics and cutting edge knowledge in the anatomy and functional organization of the circuits behind reward and aversion should allow me to decode these systems, linking discrete circuits to behavior.Collectively, the results will indicate how signals encoding aversion and reward are integrated to control addictive behavior and they may identify novel avenues for treatment of drug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Meeting Great Expectations Through Democratic Innovations' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

All across Europe democratic political systems are confronted with a citizenry that questions the democratic legitimacy of their political system. Widespread distrust in political actors and institutions, declining electoral turnout and the popularity of populist and anti-establishment candidates and parties are just a few indications of this societal challenge. Interestingly, this discontent is by no means paralleled by eroding support for democratic principles as this support is stronger than ever before. Therefore, several scholars interpreted this discontent as a demand for democratic innovation and pointed to citizen involvement in the political decision-making process as a potential solution to address this democratic legitimacy deficit.The key objective of my project is to study in depth whether, and if so how, citizen involvement in the political decision-making process affects democratic legitimacy. In a first step, citizens’ expectations for participatory and deliberative procedures are studied. Obtaining reliable knowledge on whether citizens want these procedures, and if so, what is driving this demand is crucial. It allows to assess whether democratic innovations have the potential to alleviate the democratic legitimacy deficit, and how these should be designed. To this end, large-scale cross-national surveys in over 20 European countries will be triangulated with qualitative interviews and experiments in high, medium and low trust societies. In a second step, the effect of these participatory and deliberative procedures on democratic legitimacy is studied. The focus is on democratic legitimacy as it is perceived by citizens (e.g. citizens’ political trust, losers’ consent). To address the question of effects, observational data will be gathered using panel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Real-time Fleet Performance Center (FPC) to optimize energy efficiency in Maritime Transport to reduce fuel consumption and harmful emissions' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Marorka is an Icelandic Company founded in 2002 that has developed a set of Energy Management Solutions for Merchant Ships to help them reduce their fuel consumption by up to 10%. There are presently more than 50.000 Merchant Ships sailing across the world, transporting every year 90% of total world trade (9, 84 Billion tons). These Ships use 50 to 200 tons of fuel per day, costing Ship owners / Ship operators (SOW/SOP) 4.5 to 18 million euros a year (50% of their total operational costs). Using Marorka, SOW/SOP can save 450K€ to 2,3M€ a year for each 1% of achieved fuel consumption reduction. Reducing operational costs is crucial in today’s shipping business: freight prices are dropping, reducing SOW/SOP benefits, and recently approved new regulations force SOW/SOP to drastically reduce their emissions. Marorka solutions allow SOW/SOP to remain competitive by reducing their operational costs, and comply with ever stricter environmental regulations. Marorka Solutions are composed of onboard monitoring systems that retrieve metrics from ship during operation, and online cloud based tools that allow for remote access to Ships data. Using Marorka, SOW/SOP have permanent access to their ships’ operational data, and can take informed decisions to reduce fuel consumption. Marorka Solutions have been installed in more than 600 ships during the last 14 years. Marorka is now going a step forward to create a Fleet Performance Center called SEAHUB that will allow SOW/SOP to achieve even more significant fuel savings: up to 15-20%. SEAHUB will be based on current Marorka Onboard/Online systems, but with an enhanced communications/data processing infrastructure to analyze a considerably larger volume of measurements from thousands of ships. SEAHUB will be fully interactive: it will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Predicting outcome and developing new therapeutic strategies for haematological stem cell transplant recipients using in vitro techniques.' (TRANSEUROPE), addressing dissemination and exploitation.

assistant: **Impact**

Allogeneic stem cell transplantation (SCT) is the only means of cure for haematological malignancies, as well as congenital anaemias and immunodeficiency disorders. The current poor rate of survival (30-50%) is due to post transplant complications, including infectious episodes, relapse (a lack of a graft versus leukaemia (GvL) effect) and graft versus host disease (GvHD). Tools to predict acute and chronic GvHD and/or GvL following different types of allogeneic SCT would enable new clinical protocols and therapeutics strategies to be developed based on individual patient expected risk. By the use of in vitro biotechnology, genetic and clinical risk assessments, we aim to predict outcome following therapy and SCT; develop new Europe-wide common clinical protocols and improve current therapeutic strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'MARKET EFFECTS OF COUNTRYSIDE STEWARDSHIP POLICIES' (STEWPOL).

assistant: **Concept**

Background: The environmental role of agriculture and the promotion of the countryside is taking an increasing place in the development of the E.U. and the CAP. Countryside stewardship or management agreements with farmers, with possible remuneration for the production of environmental services, are among others presented as possible policy instruments ; reg. 2078/92). However, there is still a big lack of expertise, in particular about the socio- economic and market effects of such programmes. The objectives are: The proposal will carry out a theoretical and empirical analysis in order to investigate if countryside stewardship policies are effective instruments to realise the crosscompliance between environmental and agricultural policy objectives and really contribute to market equilibrium. Short description of the project:The proposal is mainly policy oriented and tries to render some advice for programmeand policy designer. The main interest lies in the determinants of cost-effectiveness, the market impact and feasibility of countryside stewardship agreement policies. The following research topics will be clarified : - the available countryside stewardship instruments and their impact on the output at farm level? - the uptake by farmers of these policies? - the consequences on the market  - the total cost of such countryside stewardship policy in comparison with other  market instruments?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Analysis of controllability and control landscapes for quantum systems' (ACOLA) under Seventh Framework.

assistant: **Objectives**

The proposed research program is in the field of quantum control. This is a vibrant, actively-growing and highly interdisciplinary branch of science of broad interest to the physics and chemistry communities, with many researchers involved in Europe, the US and worldwide. The project addresses two fundamental topics in quantum control. The first is controllability of Markovian and non-Markovian open quantum systems (i. e., systems interacting with the environment). While controllability properties of Markovian systems have been studied, controllability of non-Markovian systems and of Markovian systems with controls addressing both the system and its local environment remain largely unexplored. The second topic is the analysis of control landscapes for both closed and open quantum systems. The quantum control landscape is defined as the objective as a function of the control field (e.g., a shaped laser pulse). The landscape structure, particularly the existence of traps, determines the difficulty of finding the optimal solutions to the underlying control problem and is therefore of great practical significance. Preliminary results of the researcher A. Pechen and the host D. Tannor show that, in contrast to recent claims in the literature, traps may exist in the dynamical landscape. The project is interdisciplinary and will apply analytical and numerical tools to quantum control problems that are at the forefront of research in physics and chemistry.The project will be performed in the research group of Prof. Tannor at the Weizmann Institute of Science. It will contribute significantly to European excellence and competition in the field of quantum control through transferring knowledge and research expertise of Dr. A. Pechen (Princeton University) from the US to Europe. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Reprogramming of elite B cells to induced hematopoietic stem cell with microRNAs and transcription factors' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Generating Hematopoietic Stem Cells (HSCs) by Transcription Factor (TF) overexpression is of great interest in the stem cell field and promises considerable therapeutic potential.  Among the systems described so far only one study, using murine B cells, has led to the generation of transplantable induced HSCs (iHSCs), although at exceedingly low efficiencies and using combinations between 6 and 8 TFs. We propose here a new approach to generate iHSCs based on the use of newly identified highly plastic “elite” type cells for reprogramming by the Yamanaka factors into induced pluripotent stem cells, generated by the transient exposure of B cells to C/EBPα. Hypothesizing that microRNAs could potentiate the effect of TFs in HSC reprogramming we will also analyze the effects of microRNA overexpression. For this we will first analyze HSCs and different hematopoietic progenitors to identify differentially expressed microRNAs. Different combinations of selected microRNAs will be cloned into inducible retroviral vectors together with hematopoietic TFs and used to infect “elite” CEBPα-primed B cells to screen for the induction, in vitro and in vivo, of iHSCs. The use of colony assays, cell surface marker and transcriptomic analyses of the resulting cells, as well as transplantation into irradiated mice, will enable us to identify microRNAs and TFs combinations that induce HSC reprogramming. The heterogeneity of iHSCs will then be tested by single cell expression analysis using RNA-seq. This project will provide new insights into the reprogramming of HSCs, the clinically most important type of adult stem cells, with potential medical applications. The proposed action will benefit the applicant’s career through acquisition of scientific maturity and independence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Regulation of inflammasome activity through NLRP3 ubiquitination level' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The innate immunity constitutes an efficient barrier by rapidly detecting pathogens and tissue damages through pattern recognition receptors including NLRP3. On the other hand, inappropriate NLRP3 activation causes deleterious inflammation and contributes to various conditions including atherosclerosis, diabetes, gout and Alzheimer's diseases. Therefore NLRP3 requires tight regulation that remains poorly characterized. Activated NLRP3 assembles a multimeric inflammasome complex serving as activation platform for caspase-1 that controls processing and release of cytosolic cytokines including IL-1β. We recently evidenced that inflammasome assembly requires NLRP3 deubiquitination by the deubiquitinase BRCC3. The aim of this proposal is to decipher this new ubiquitin-dependent regulatory pathway critical for NLRP3 activation. We propose to identify stimuli, signaling pathways and enzymatic complexes controlling NLRP3 ubiquitination level. Using both cell biology and biochemistry approaches, we will decipher the molecular mechanisms beneath the regulation of the deubiquitinase and ubiquitin ligase complex activity, as well as the loss of activity of ubiquitinated NLRP3. Lastly, we will test the in vivo relevance of NLRP3 ubiquitination using both mouse models, patients study and pharmacological approach. Altogether, this project will thoroughly characterize this new pathway controlling inflammasome activity and provide new therapeutic targets against inflammation related diseases that are highly prevalent in the European Union.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Best practice GIS integrated processes'.

assistant: **Concept**

Unrealised potential of best practice Geographical Information Systems (GIS) support for business processes across business domains:The geographic dimension in business interaction and cooperation between European public entities and private and public enterprises accounts for a significant volume of economic activity. The business processes involved are complex and cover relationships between suppliers, customers, authorities, agencies and citizens. Information technology in terms of Geographical Information Systems (GIS), Workflow Management Systems and Process Modelling/Enactment Systems are increasingly supporting these business processes, but the full potential of best practice implementation is rarely realised and documented.Significant impact on European competitiveness from Best Practice GIS Concept: The effectiveness of these business processes is recognised as having significant direct and indirect impact on the competitiveness of European business in both the public and private sector. Therefore, a general best practice GIS based concept will through replication in other GIS supportable business processes across business domains potentially have an enormous benefit.Purpose and specific results: The purpose of the business best practice pilot definition phase project is to establish a best practice concept for subsequent implementation and replication. The result of the definition phase project will be a GIS based process concept, a performance measurement approach, a cost/benefit assessment and increased experience for the participating users and methodology and tools suppliers.Holistic perspective and approach on core business processes: The project adopts a prerequisite holistic perspective (i.e. focusing on end-to-end core business processes and life-cycle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A novel medical device for the treatment of Endometriosis' (EndoSolve).

assistant: **Innovation**

Endometriosis is one of the most prevalent, impactful and undertreated disorders to affect European women. The condition is defined as an estrogen-dependent disorder, where endometrial tissue forms lesions outside the uterus resulting in chronic pain and infertility. Endometriosis affects an estimated 10% of European women in the reproductive-age group (176 million women worldwide and 10.7 million in the EU) with significant impact on their physical, mental, and social well-being (This impact is exacerbated by the fact that the correct diagnosis is made as late as 8–11 years after symptom presentation. Treatment delays are due to a lack of a reliable non-invasive diagnostic test, and the fact that the reference diagnostic standard is laparoscopy (invasive, expensive and not without risks). As there is no permanent cure for endometriosis, current therapies have three main goals: (i) to reduce pain; (ii) to increase the pregnancy rate for women who desire to have children and (iii) to delay recurrence for as long as possible. The EndoSolve project will develop the first medical device to treat the underlying mechanism of endometriosis, providing a long-term non-pharma treatment for the chronic disease.