RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Gate2Growth Finance Academia network for academics in entrepreneurship, innovation and finance' in the context of a Fifth Framework call.

assistant: **Objectives**

Gate2Growth Finance Academia aims at building and supporting a truly open pan-European network of academics, researchers and scholars in the fields of entrepreneurship, innovation and/or finance. By creating this network of excellence the general objective is to develop a European entity of relevance for its subject in terms of its coverage of the potential population of actors, including universities, business schools and other research centres. Hence, to become the European number one reference for state-of-the-art academic research and teaching in these themes.The Gate2Growth Finance Academia network's primary actions include:- to carry forward the integration on a pan-European level of applied and fundamental research and teaching practices in the central project themes;- to support the exchange and mobility of junior and senior academics, researchers and scholars in these fields;- to disseminate breakthrough research and teaching methodologies and best practices, case studies as well as a broad diversity of applied and fundamental research output to a wider research, policy and business audience. In the long run, this will enable the network to become the reference in Europe for the support, generation and dissemination of academic research and teaching at the cross-links of entrepreneurship, innovation and finance and to become a prime partner for the EC to actively formulate policy guidelines based on the translation of the more fundamental research findings into practical insights and policy recommendations.Work plan description:WP1: Networking with other academics, researchers and scholars in entrepreneurship, innovation and finance;WP2: Annual Doctoral Track;WP3: Researcher Exchange and Mobility;WP4: European Case Study writing;WP5: Best Paper Award competitio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Research & development for the creation of a new system of spheric structural bearings to avoid the impact of importan horizontal forces problems on transport infractructures'.

assistant: **Objectives**

The main goal of this project is to create a system of structural bearings with new mechanical characteristics to solve the problem of transmitting high horizontal forces (such as braking for trains or seismic vibrations) on construction infrastructures (such as piles of bridges) . The idea is to share these horizontal forces evenly through a specific system Of bearings in stead of concentrating these forces on one unique bearing . This research would help to preserve the construction infrastructures of deflections or torsion caused by these important (hundreds of tons) forces . The research would include the study of specific brake springs with controlled stiffness and of specific components . This new bearing system would replace unskilled existing technologies (each bearing is dimensioned to receive the total force) and provide the possibility of creating new type of bearings with evident economical and safety profits . The SME proposers - manufacturers of structural bearings, aseisrnic devices, expansion joints, - would be interested to contribute to this project and work with RTDs dedicated to studv and specifications of the prototype of bearing, performing tests of this prototypes, and study of new material (teflon, carbon. titanium. rubber ) .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Trapping intramembrane protease substrates in living cells: focus on RHBDL4 role in ERAD' under Horizon 2020.

assistant: **Concept**

Intramembrane proteolysis is increasingly understood to control many cellular processes but we still know little about the role of most intramembrane proteases. The major roadblock is the lack of a robust method of protease substrate discovery. In this action, I focus on RHBDL4, a poorly understood but highly conserved member of the rhomboid intramembrane serine protease family, which participates in ER associated degradation (ERAD), apoptosis and exocytosis, and which has been frequently implicated in cancer growth and metastasis.My three objectives are to establish a systematic approach to trapping and identifying rhomboid substrates; to use this to discover the substrates of human RHBDL4; and to explore the mechanism of how RHBDL4 participates in ER quality control.Matthew Freeman's group discovered rhomboids and is a leader in the field. I will also collaborate with Jason Chin in Cambridge, who has pioneered the use of genetically encoded unnatural amino acids (UAAs) to engineer proteins. I will adapt a technique recently published by the Chin lab for use in living cells. Using a cross-linking UAA analogue of the catalytic serine in RHBDL4, I will achieve unprecedented specificity and efficiency of substrate capture. I will thus covalently capture RHBDL4 substrates, which will then be identified by mass spectrometry. Hits will be functionally validated and, using a range of experimental conditions, I will distinguish substrates involved in ERAD from substrates cleaved in other RHBDL4-dependent processes.By establishing the first systematic assay for rhomboid substrates and investigating the role of RHBDL4 in ER quality control, I will pioneer a general approach to intramembrane protease substrate discovery; gain broader understanding of how RHBDL4 contributes to cel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Three dimensional tectonic evolution within oblique continent-continent collision'.

assistant: **Objectives**

Orogenic (i.e., collisional belt) evolution is classically viewed in two-dimensions, and most models use cross-sections oriented perpendicular to mountain belts in order to describe the general transfer of material and heat. Changes in processes in the third dimension are, however, increasingly recognized as crucial where there is oblique convergence (transpression). Transpressive mountain belts include ( e.g.,) the Himalaya, Alps, and North America Cordillera. Although previous tectonic modeling and thermochronologic studies from active convergence zones (e.g., Southern Alps, NZ) have revealed large and unexpected modifications to 2D models for 3D consideration of oblique subduction, the 3D spatial variations in thermo-tectonic processes within the mid- to upper-crust during oblique collision are less investigated and still poorly understood. It is likely that these variations are also large, and our understanding of crustal processes is therefore inadequate. I propose to address this by investigating the nature and timing of tectonic evolution in the central Karakorum region of the western India-Asia collisional belt; an area of enhanced transpression. Mid-crustal rocks here are re-worked and exposed as a series of domal structures within a narrow corridor. I will visit these domes and carry out structural mapping & fault-surface analyses in conjunction with systematic sampling for micro-structure, & -texture analyses, and to apply geochronologic techniques (U/Pb, Ar-Ar) on different mineral systems. This will characterized which principal structures operated when, for how long, and at what temperature. Integrated numerical modeling of all the data will provide a clear picture of how transpressive collision works.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Genetic and functional analysis on the role of the novel homologues of angiotensin converting enzyme (ACE) in angiogenesis/blood vessel formation' to be submitted under Sixth Framework.

assistant: **Abstract**

Inhibition of new blood vessel formation is a promising therapy against cancer, diabetic retinopathy, or rheumatoid arthritis where pathological angiogenesis occurs. However, as shown by the failure of some angiogenesis inhibitors in clinical trials, the m olecular mechanisms of angiogenesis are still elusive and more effective and fine-tuned therapies for angiogenic diseases are awaited. New evidence indicates that angiotensin II, generated by angiotensin converting enzyme (ACE), contributes to the progress ionof diabetic retinopathy and some cancers. The precise role of the renin-angiotensin pathway in angiogensis is unknown. Josef Penninger's laboratory recently identified a novel homologue of ACE, termed ACE-2. In genetic experiments his group showed that ACE2 is a candidate QTL for hypertensions and that loss of ACE2 results in heart failure and decreased heart functions (Crackower et al. Nature 2002). These data provided the first genetic evidence that the renin-angiotensin system has a critical and direc t role in the heart and introduced a novel paradigm for negative regulation of the renin-angiotensin pathway, i.e. ACE2 counterbalances the function of ACE. The goal of this proposal is to identify the role of ACE-family molecules ACE, ACE2, and collectrin and their vasoactive peptide substrates such as angiotensin II in angiogenesis and to develop novel therapeutic strategies to modulate new blood vessel formation in disease. We propose to investigate angiogenesis in knockout mice of ACE, ACE2 and collectr in as well as mice that have mutations in the ACE/ACE2 substrates angiotensinogen, apelin, and bradykinin using murine angiogenesis models. We hypothesize that adult angiogenesis in mammals is conserved in primitive vascular development in fruitfly, since a P-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'All Magneto-Electric Spin Logic Gates' under Horizon Europe.

assistant: **Concept**

The surge in electronic equipment used daily across the globe, from end-user devices to data centres, has led to a craving for more energy-efficient computing devices. However, the current Moores Law epitomised miniaturisation process of CMOS transistors will be gradually limited by increasing power densities and associated chip heating. Therefore, much research has been devoted to the development of alternative computing devices. Spintronic devices, which exploit both the charge and the spin of electrons, are seen as a promising beyond-CMOS approach due to their ultralow energy per operation, non-volatility, and capability to build more expressive logic gates. Despite much recent success in realizing spintronic logic gates such as those that employ magnetic domain walls or spin waves as information carriers, there are two major limitations that impede the inclusion of such devices in microelectronic technologies. The first is the lack of energy-efficient transducers for interconversion of signals between the magnetic and electrical domains. The second issue is the inability to propagate magnetic information carriers over large distances in the magnetic domain, i.e., the lack of magnetic interconnect. To address these challenges, we propose a novel spin logic device concept (ALLME) based on layered strain-mediated magnetoelectric composites containing both piezoelectric and magnetostrictive materials. By exploiting its magnetoelectric effect, the magnetisation in a nanomagnet can be rotated with voltages, and in the inverse effect, the change in magnetisation will result in a voltage output. ALLME aims to deliver one of the most technologically competitive spin logic concepts, with an emphasis on ultra-low energy consumption and all charge-based interconnects that are r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enhanced COntrol centres for fixed and Moving Block sIgNalling systEms - 2', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

COMBINE 2 aims at investigating an innovative solution for managing rail traffic in real time, to provide improved service and better exploitation of existing infrastructure. The proposed solution utilises detailed real time information on train positioning to provide timely short-term plans and optimise train speeds accordingly. COMBINE 2 extends the research developed within the COMBINE project (which focused on a local area equipped with moving block) to large networks equipped with fixed and moving block signalling systems. COMBINE 2 will achieve its objective by means of state of the art scheduling algorithms and co-ordination policies for managing the interaction among Traffic Management Systems (TMSs) controlling adjacent railway areas. A demonstrator will be developed, able to deal with large networks equipped with different signalling systems. The demonstrator will be validated via simulation, and utilised to evaluate the potential benefits of a new generation of TMSs.Objectives:COMBINE 2 will assess the competitive advantage of using the traffic management approach to increase railways capacity without adding infrastructure or changing signalling systems, thus helping railway companies to improve their services to passengers and freight operators. COMBINE 2 will assess the impact on rail traffic management of installing in-vehicle positioning and communication equipment, in order to reduce the technical gap between current and future signalling systems. COMBINE 2 will target the new generation of TMSs able to manage efficiently large railways networks equipped with mixed signalling systems. To reach these objectives, COMBINE 2 will also devise new approaches for traffic optimisation and new methodologies for managing the interaction among TMSs controlling adja
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ada 2020 | Visual Reasoning Support for Healthcare Professionals' under Horizon 2020.

assistant: **Concept**

Ada has developed a unique visual reasoning tool for medical professionals that offers diagnosis decision support at the point of care. The award-winning user-interface of Ada is designed to activate the interplay between analytical and integrative thinking skills of the physician. After three years of fundamental research in new reasoning technologies, Ada is now able to capture knowledge from medical experts, transform it into a medical reasoning engine and deliver it directly to the point-of-care in a patient-specific manner. The goal of Ada/DX is to help the doctor: i) avoid misdiagnosis, ii) support diagnosis decision-making for even the most complex cases in a robust and efficient way, iii) simultaneously document the diagnostic process according to both clinical and legal requirements. Reducing the number of misdiagnoses and wrong treatments can help to reduce personal suffering of the patients and healthcare costs simultaniously. A study revealed that misdiagnoses and wrong treatments in the field of vertigo diseases cost about 1 Billion EUR per year in Germany. According to a recent study on the Healthcare decision support field (WinterGreen research – 2013), wrong test and test that are not usefull in a particular situation, account for 30% of the costs of the healthcare delivery in the US. Overall the project will end in a full working Software as a Service (Saas) product. The M10-accuracy of today 85% will be increased to > 95%, by simultaneously increasing the number of common diseases from today 800 to 3.500 plus 6.000 rare diseases. Three user targeted products will be set up, adressing three market segments: GP-Service, Expert-Service, Prevention-Service.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Transformations of Food in the Eastern Mediterranean Late Bronze Age'.

assistant: **Objectives**

Mediterranean cuisine has long been perceived as a timeless constant, already linking the different societies around the sea by the 2nd mill. BC. The geographic frame was considered to be essential, whereas intercultural entanglements as transformative factors were neglected. By integrating archaeological, textual and scientific research, we will shed new light on the transformative power of cultural encounters arising from the intense connectivity between local communities in the Eastern Mediterranean Late Bronze Age and the simultaneous introduction of food of South and East Asian origin (e.g. pepper, nutmeg, cinnamon). We intend to achieve this goal by analysing human remains and pottery vessels from selected sites between the Aegean and Egypt from the 15th to the 12th cent. BC to trace spatial and temporal dynamics. Organic residue analyses of the pottery will shed light on the preparation and consumption of food (e.g. oils, wine, spices). We will include vessels with their contents labelled on them and then link so-far hardly understood Egyptian textual evidence to the contents, which enables a new understanding of these texts for the study of food. We combine the results from residue analyses with a cutting-edge approach to the study of human dental calculus, the potential of which has just been recognized for the understanding of human nutrition: we will analyse DNA from food traces and bacteria as well as proteins, lipids and microremains in dental calculus. This will give unique insight into individual consumption of different oils (olive, sesame etc.), kinds of milk (cow, sheep, goat) and related products (cheese, kefir) and of plants (spices, cereals), which goes far beyond what has been achieved to date. The linkage of food residues in vessels and calculus w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of novel matrices and encapsulatory materials for support and modulation of hair follicle growth' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives and content The skin is the largest organ of the human body and there is an enormous market (56 billion ECU) in pharmaceuticals and cosmetics targeted to it. A major goal of both the cosmetic and pharmaceutical industries is to develop in vitro models of the skin that accurately reflect the in vivo state and that can be used for both basic research and also to develop and screen novel actives and targeted delivery systems. Current models do not fully reflect the in-vivo situation and there is a clear need for new models. The Partners propose the development of novel scaffolds and matrices that will support the in-vitro maintenance of histocultured human skin as well as isolated human pilosebaceous units (PSUs) and hair follicles. In addition their suitability as matrices for developing synthetic organs/tissues capable of supporting hair follicle and skin gland neogenesis will be investigated. Through concertation of their expertise the four partners, QMWC, L'OREAL, FAB and HUB will bring the following innovations to the field of tissue engineering: The first rationally designed, smart dermal matrices which will: - release growth factors - be biocompatible with epidermal matrices - support proliferation and differentiation of PSUs The first use of hyaluronic acidbased polymers and/or methacrylate/phthalate-based viscoelastic entanglement gels for the support of proliferation, differentiation and cycling of hair follicles or PSUs. The first combination of wholly synthetic dermal and epidermal matrices with appropriate cell populations to create an hairy skin-equivalent The first use of simultaneous beta-imaging and light microscopy for the analysis of active delivery to the hair follicle or PSU The proof-of-principle that actives can be directly delivered to sp