RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Optofluidic toolkit for characterizing single-cell dynamics in systems immunology' (SINGLECELLDYNAMICS).

assistant: **Innovation**

Immune cells constantly receive signalling inputs such as pathogen-emitted molecules, use gene regulatory pathways to process these signals, and generate outputs by secreting signalling molecules like cytokines. Characterizing the input-output relationship of a biological system helps understanding its regulatory mechanisms, and allows building models to predict how the system will operate in complex physiological scenarios, such as population tissue response to infection.  A major obstacle in this endeavor has been the so-called “biological noise”, or significant variability in measured molecular parameters between cells. Such variability makes time-dependent single-cell analysis crucial to understand how biological systems operate. Development of new analytical tools with improved functionality, accuracy, and throughput is needed to realize the full potential of single-cell analysis. We propose to develop automated, high-throughput, Optofluidic single-cell analysis systems with unprecedented capabilities, and to use them in understanding how immune cells organize in tissue during response to infection. Microfluidic membrane-valves, nanodroplets, optics, and automation will be integrated to achieve an unparalleled degree of control over single immune cells. Multi-functional lab-on-chip devices will simultaneously measure: a) The activity of immune regulatory proteins such as NF-κB, and b) Inflammatory cytokines secreted from single immune cells in a time-dependent manner, under precisely defined biochemical inputs. Characterizing macrophage cytokine secretion dynamics under combinatorial regiments of bacterial and apoptotic-cell signals will allow dissecting the signalling mechanism responsible from the resolution of inflammation. We will identify the role of the NF-κB
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'BRIDGING THE GAP BETWEEN HORIZONS THROUGH TRANSNATIONAL COOPERATION OF ITS NCP SUPPORT STRUCTURES' (Bridge2HE), addressing dissemination and exploitation.

assistant: **Impact**

The NCP systems are support structures established by MS and AC and recognized by the European Commission in order to help participants to access the different EU Programme opportunities. For Horizon 2020 (H2020) there are 21 NCP defined functions apart from the NCP coordinator, giving support to participants across the different parts of H2020.In order to ensure cooperation among NCPs from different countries, improve mutual learning between them and develop dedicated tools and services for participants, the European Commission has historically funded the NCPs through NCP networks CSA projects, in variable geometry of partners, covering typically one NCP “function” per project and renewing it, with a follow-on project, approximately at the middle of each Framework programme. Taking advantage that the current H2020 NCP network projects finalize at the end of 2020 and the new NCP network projects will not start at least until Q3 of 2021, this project, under the leadership of the national NCP coordinators has a unique window of opportunity to lead the effective integration of the NCP systems into a coherent frame of work for Horizon Europe. Our project, Bridge2HE, is the agreed response of 22 NCP host organizations across Europe to the challenge of an efficient transition to Horizon Europe, both from the NCP systems’ perspective but also from the support to participants’ perspective. Our project does not only enable a degree of continuity to the current NCP structures and network coordination but also it goes a step further making a real integration of the NCP networks offer under a common portal, the Horizon Europe NCP Portal. During this transition Bridge2HE will implement more than 20 training activities; tools and services for NCPs and applicants; 6 big brokerage even
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Promoting Osteogenesis through Vascular Endothelial Cells' (PROVEC) under Horizon 2020.

assistant: **Objectives**

The skeletal system and its vasculature form a functional unit with great relevance in health, regeneration, and disease. Our recent work has provided fundamental insights into the organization of the bone vasculature in mouse, its changes during aging, the heterogeneity and functional specialization of bone capillaries and endothelial cells, the regulation of these properties by Notch and hypoxia-inducible factor signaling, and the crosstalk with osteoblast lineage cells. Most importantly, we found that the manipulation of ECs in the aging animal can trigger the expansion of osteoprogenitors and thereby induce bone formation. PROVEC will now systemically identify and characterize endothelial cell subpopulations, their gene expression and functional properties in the healthy, aging, diseased and regenerating skeletal system. Preclinical models will establish whether endothelial cells are involved in the response to therapeutic treatments aiming at osteoblasts or osteoclasts, or if the modulation of ECs alone is sufficient to generate beneficial effects. Finally, PROVEC will investigate whether cultured mouse and human ECs can be endowed with beneficial properties to enhance bone formation in 3D organoid cultures and after transplantation into mice, which will be monitored by imaging in living animals.To achieve its ambitions aims, PROVEC will use a powerful combination of mouse genetics, disease models, genetic fate mapping, RNA-seq and single cell sequencing, computational biology, confocal and 2-photon microscopy, micro-CT imaging, pharmacological treatments, and cell biology methods to establish if and how vascular endothelial cells can be used to increase bone mineral density in preclinical models.The successful completion of PROVEC would be highly relevant for dise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The development of a high power density RAPID response on demand water HEATing technology' (RAPIDHEAT) under Seventh Framework.

assistant: **Objectives**

The RapidHeat project utilises emerging materials science applied in the power electronics industry and an efficient heat management system to develop a modular, high flow rate, on demand, in line water heater for flexible and rapid response to hot water demand. Its low cost, light weight and small size will enable flexibility in the design of hot water systems minimising cost and energy consumption. Furthermore, zero heat loss will be produced from our RapidHeat technology which goes beyond standards set by the EuP directive.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Modelling of Twin Screw Granulation on Micro-Macro Scales' (MODSIM).

assistant: **Innovation**

Pharmaceutical manufacturing companies use various powders to prepare granules/tablets with stable attributes. However, wastage costs in the manufacture of solid dose drugs are of the order $50 billion. Much of this is due to a lack of fundamental knowledge of the physical processes occurring inside the particulate processes. In this project, common manufacturing systems such as are twin screw granulator (TSG) to produce suitable granules/formulations will be studied. A fully mechanistic understanding of these processes will be undertaken with the objective of reducing the manufacturing wastage and handling cost of the TSG using the skills and knowledge of the experienced researcher (ER) and the host supervisor. Improving this efficiency will play a key role in ensuring a more sustainable production system through less wastage into the future, a societal challenge which will be met by the H2020 programme.MODSIM is a multidisciplinary project aimed at exploiting my background in mathematical modelling of particulate processes using population balances in an area of pharmaceutical solid drug manufacturing. Apart from its manufacturing potential, this research will broaden current understanding of micro scale processes inside the TSG using MC method. The project forms a collaboration between the world leading Bernal Institute for Process Engineering research laboratories and an SME and exploits the multidisciplinary nature of their studies. The resulting knowledge will help EU manufacturing enterprises, in particular SMEs, to adapt to global competitive pressures by improving the technological base of EU manufacturing from pharma and importantly potential translation into high-value bioprocessing and med-tech sectors. The proposed research will provide outstanding research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New paradigms for correlated quantum matter: Hierarchical topology, Kondo topological metals, and deep learning' under Horizon 2020.

assistant: **Concept**

Discovering, classifying and understanding phases of quantum matter is a core goal of condensed matter physics. Next to the notion of symmetry breaking phases, the concept of topological phases of matter is a prevailing theme of recent research. Topological phases are envisioned for various applications due to their universal and robust properties, such as protected conducting boundary modes, and provoke fundamental questions about the nature of many-body quantum states by providing the basis for exotic quasiparticles.In this ERC research project, I propose several new topological phases and novel numerical approaches for studying and classifying the most sought-after topological phases of matter. Concretely, I propose the concept of three-dimensional hierarchical topological insulators, which, in contrast to the known topological phases, do not posses gapless surface, but protected gapless edge modes. Moreover, I plan to study topological metals arising in strongly correlated Kondo systems, going beyond the current paradigm of considering topological metals that arise in the absence of electronic correlations. Furthermore, I propose to make the analogous step for topological superconductors, which have been studied as free models to search for Majorana quasiparticles: For the first time, I want to explore strongly interacting systems that realize the more powerful parafermion quasiparticles with numerical techniques. Finally, in a cross-disciplinary and exploratory sub-project, I will employ methods of deep neural networks to classify strongly correlated quantum phases using supervised learning combined with a technique called deep dreaming.  Each of these sub-projects has the potential to make a paradigm-changing contribution to the study of strongly correlated and to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Somatostatin Receptor Inhibitors for Sustaining Muscle and Bone Mass Following Pharmacologically Induced Weight Loss' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Obesity affects 1 in 6 adults in Europe, driving demand for therapy. Agonists of the Glucagon Like Peptide 1 Receptor (GLP1RAs) such as semaglutide (Novo Nordisk) and tirzepatide (Eli Lilly) have led to substantial weight loss in millions of patients. However, a large fraction of lost weight is attributed to loss of lean mass: muscle and bone. A reduction in lean mass increases the risk for sarcopenia and osteoporosis  loss of muscle and bone. Our analysis of 748,667 patients using GLP1RAs has shown that most are women, over the age of 50: a population already at risk for muscle and bone loss. Sarcopenia and osteoporosis cause pain, fatigue, limit the ability of patients to perform daily activities, and increase their risk for fractures. With millions of GLP1RA users and an annual direct cost of 5000USD/osteoporosis patient, loss of lean mass can cost billions to health care systems.Growth Hormone (GH) is the natural signal in adults for sustaining lean mass. Results from our ERC project identified pathways that may sustain GH signaling during and after weight loss. We propose to develop novel molecules that will lead to an increase in natural GH secretion. We will test the efficacy and safety of a library molecules we designed for their ability to maintain lean mass during GLP1RA-induced weight loss. The results will secure the intellectual property surrounding the novel molecules and their use.By addressing the underlying causes of muscle and bone loss, we aim to develop a comprehensive solution to the obesity crisis. Our innovative biochemical approach targets the aging population struggling with obesity and has the potential to prevent disease in millions of patients and alleviate a significant burden from healthcare systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Harmonising population-based biobanks and cohort studies to strengthen the foundation of European biomedical science in the post-genome era' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

This coordination action aims to establish a collaborative research network that will identify and explore key issues that will help to ensure that Europe makes best use of its rich array of population-based biobanks and longitudinal cohort studies. These include major cohorts that already exist and exciting new initiatives that are just starting up. The ultimate aim is to harmonise those features that are common to many such studies and that, when harmonised, will help to: (1) promote communication between major biobanking initiatives; (2) enhance the effective sharing and synthesis of information and data; and (3) avoid the expensive mistakes and inefficiencies that can arise when individual initiatives repeatedly re-invent the wheel". Because of its large and varied population-base, the population-centred nature of many of its health systems, and its past emphasis on the importance of population-based cohort studies, Europe is well placed to capitalise on the biomedical research opportunities that exist in the post-genome era. If we can ensure that our biobanks are able to work together to address pivotal research questions that fall outside the scope of projects funded by single nations, or even of large cohorts running across several nations, we can ensure that Europe remains at the cutting-edge of biomedical research internationally. Our long-term aim to harmonise large population-based biobanks and cohort studies in this manner is unashamedly ambitious. But it can undoubtedly be realised if it is approached in manageable stages. Given the pre-existing thought that has already been put into such harmonisation under initiatives such as the EU funded COGENE project and the Public Population Project in Genomics (P3G) with Canada, and under EU funded projects such as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nano-Sensitizer Cancer Cell Targeted Radiotherapy' under Seventh Framework.

assistant: **Concept**

Targeted chemotherapy in combination with external beam radiation therapy (radiotherapy) is a promising approach to significantly improve the therapeutic outcome for cancer patients. To achieve this, it is essential to develop drug delivery technology that specifically delivers the chemotherapeutic drugs to cancerous tissue. Radiotherapy is an indispensable part of modern cancer treatment; however, despite efforts in improving planning and execution of treatment, the unbalance between therapeutic benefit and side effects limits cure rates, and new approaches are needed to bring to fruition the full potential of radiotherapy. Today, there is considerable focus on systemically administered radiosensitizers for enhancing the effect of radiotherapy and clinical investigations have shown promising results; however, radiosensitizer use is hampered by considerable side effects due to lack of drug targeting to the cancerous tissue.In the first phase of this project, the aim is to develop tumor targeted nanocarrier delivery systems of radiosensitizers to enhance their therapeutic potential and provide a more efficient and site-directed effect of radiotherapy. In the second phase of the project, nanocarriers for tumor specific delivery of checkpoint inhibitors of cancer cell repair mechanisms will be investigated as an additional targeting strategy for sensitizing cancer cells to radiotherapy. The idea is to circumvent cell cycle checkpoints of DNA damage induced by tumor radiation and thereby enhance mitotic catastrophe. This approach will in combination with the delivery of conventional radiosensitizer drugs, further lower the radiation dose needed to induce irreversible damage to cancer cells.Thus, the project aims to develop targeted nanocarriers for high precision delivery o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'In line ellipsometer for thickness control' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

- To integrate and evaluate the SD 4000 in a vertical furnace process cell of a high volume 4 Mb, 0.8 micron process line.- To prove its versatility, accuracy and cost effectiveness for measuring a range of thin, single and multiple films.- The layers to be evaluated include single layers in the range 4 nm - 1000 nm, multiple layers of ONO, OPO and monitoring of CMP processes.The assessment of the Plasmos SD 400 ellipsometer is to be carried out in the production environment of SMST. The result will be a benchmark showing best of breed features: precision, measurement capabilities (e.g. interferometer emulation for thin and thick layers, poly-Si, multilayers, multipurpose), throughput, cost-of-ownership.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Development of high quality engineering materials based on natural fibre composites by optimising the interface characteristics'.

assistant: **Objectives**

Research objectives and content  The interfacial properties need to be explored in order to optimise the strength and toughness of composite materials. This project aims to study the interface in composites manufactured from (waste) thermoplastic resins such as PP, PBT, PET,PE, PS etc. and (waste) lignocellulose fibres such as cotton, wood, flax, sisal etc. in order to optimise the mechanical behaviour of these materials for a potential usage in engineering applications. Surface treatment of the fibres will be performed to alter adhesive properties, then the fibres and matrix will be characterised taking into consideration the chemical, physical and mechanical adhesion. The interface between fibre and polymeric matrix will be characterised by micromechanical testing in single fibre, monolayer and bulk composites. Finally the transcrystallinity around the fibre and its effect on the interface will be studied. Training content (objective, benefit and expected impact)  Working on this project will be very helpful for the training of the applicant, since she will be able to acquire valuable experience in scientific areas such as physical, chemical and mechanical characterisation of composite materials. She would be also very helpful for her country, since Greece needs well trained and qualified scientists especially in fields where modern technologies with respect towards the environment are involved.