RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Design of the European mobile network operator for research' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The objective of EuWireless proposal is to develop the design of the first pan-European infrastructure to support research in mobile communication networks using regulated spectrum, with the goal of contributing to keep Europe’s leadership in mobile communication technologies. The output of the project will be a complete design report addressing the pan-European operator, the regulatory aspects, the business model, the technical solutions and the roadmap for implementation of the proposed infrastructure, as well as prototypes that confirm its feasibility.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exosome and ribosome coupling' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

To date, mechanistic studies on the macromolecular complexes that synthesize or degrade RNAs or proteins have investigated these machines individually to understand how they execute different steps in the gene expression process. Although the individual complexes catalyze their reactions independently of each other in vitro, increasing evidence suggests that they function in a highly coordinated manner in vivo. The molecular basis for such a coordination remains largely unknown. During the past five years, our group has focused on deciphering the mechanisms of multiprotein complexes that mediate mRNA turnover in S. cerevisiae. Here, I propose to take these analyses to the next level and visualize how a major RNA degradation machine, the exosome, is directly coupled to the protein-synthesis machine, the ribosome. In particular, we want to study two different exosome-ribosome assemblies that underpin opposite outcomes of RNA degradation: a constructive function of the nuclear exosome in the maturation of the large ribosomal subunit and a destructive function of the cytoplasmic exosome in the elimination of ribosome-bound mRNAs. Building on our preliminary data from both the yeast and human systems, we will use a combination of bottom-up biochemical reconstitutions and top-down endogenous purifications to isolate 1) an exosome complex and its nuclear cofactors bound to a pre-60S ribosomal subunit and 2) an exosome complex and its cytoplasmic cofactors bound to a stalled 80S ribosome. We will determine the structures of these ~3 - 4 MDa nuclear and cytoplasmic assemblies using the combined information from cryo-electron microscopy and X-ray crystallography approaches. The structural  studies, combined with biochemical and genetic information, will reveal how these machines
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Heterotypic Cell Interactions in Hepatitis induced Liver Cancer' (LIVERMIRCOENV), addressing dissemination and exploitation.

assistant: **Impact**

The link between inflammation and cancer is now established, yet the underlying molecular mechanisms are unresolved. As tumors progress, they modulate inflammatory cells towards a pro-tumorigenic phenotype. We have shown that inflammatory cells reciprocate by sculpting the parenchymal epithelial cells. I hypothesize that these reciprocal interactions lie at the heart of the link between inflammation and cancer.Hepatocellular carcinoma (HCC), one of the deadliest tumors, is a prototype of inflammation induced cancer. My team will employ a twofold strategy to analyze the changes occuring in inflammatory cells before and after tumors emerge, based on preliminary findings showing that changes in inflammatory cells precede tumorigenesis. First, we will perform comprehensive mapping of the changing inflammatory microenvironment in a mouse model of inflammation induced HCC. We will employ genetic manipulation strategies, coupled to cell isolation techniques to delineate the molecular cues that mediate these changes and then will analyze the functional role of key mediators of these processes in HCC. Microfluidics approaches will give us a highthroughput quantitative view of these heterotypic interactions. The same approaches will be harnessed to identify the interactions that form the liver stem cell niche which dramatically expands in states of chronic inflammation. Second, drawing on our finding that a recurring tumor amplicon drives HCC progression by modulating the microenvironment, we will work towards identifying additional similar amplicons to define additional key effectors of the microenvironment.Of special importance, heterotypic cell interactions that play key roles in both cancer initiation and progression, present ideal therapeutic targets, which are easily access
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CAPACITATION OF A PORTUGUESE R&I CENTRE OF EXCELLENCE FOR PLANT PATHOGENS DETECTION AND CONTROL' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

BiomeHealth aims to strengthen European and Portuguese R&I on agro-food systems that face climate change and new/recurrent pathogens, with the support of Wageningen Univ. & Research (WUR, NL) and Bologna Univ. (UNIBO, IT).Global trade and climate change favor the establishment of new pathogens in Europe. Portugal needs to boost R&I and education/training to empower a new generation of researchers in this field. BiomeHealth has two R&I objectives, and four capacitation objectives aligned with the Twinning call. WUR (precision pathogens detection), and UNIBO [VOC-biosensors, Biological Control Agents, and SynComs] will develop R&I and capacitation of the widening partner, Requimte/UP that leads the national research in agrifood. This capacitation networking will use groundbreaking concepts of plant microbiome, precision detection, and engineering of synthetic communities (SynComs) of BCAs (supported by artificial intelligence, AI).BiomeHealth structure has six interdependent WPs: WP1 is for Coordination and Management; WP2 deals with R&I on precision detection and control of phytobiomes also challenged by climate change (as a case study we will use Pear/Apple trees under an RCP8.5 climatic scenario, and challenged with Erwinia amylovora, and Stemphylium vesicarium). New detection tools/matrices (e.g., aerobiomes), dynamics host-microbiome-pathogen, and SynComs, will be unveiled/tested for the RCP8.5 condition. WP3 (precision detection) and WP4 (Control using SynComs) are dedicated to the capacitation of Requimte/UP, with dedicated short-term visits, training/advanced courses, summer schools, etc. WP5 will build a sustainable structure through a R&I roadmap of Requimte/UP for 2030, and the creation of a Centre of Plant Pathogen Detection and Control. Finally, WP6 deals wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Microelements in Life Expectancy and Aging' in the context of a Horizon 2020 call.

assistant: **Objectives**

Increased longevity with a high quality of life is desirable not only for personal life-satisfaction but also for reducing healthcare costs and for increasing the socioeconomic contributions of individuals in countries with ageing population demographics. Lifelong lifestyle has an important impact on health status in older age and adequate nutrition plays a key role in maintaining cellular functions within normal limits. Microelements such as zinc (Zn) and copper (Cu) are essential for life and are involved in the normal functioning of thousands of proteins. The dysregulation of these metals leads to perturbed homeostasis, disease and diminished quality of life. In this study, the molecular mechanisms by which ageing affects Zn and Cu absorption and excretion will be determined, and the consequent impact on metal flux and transport kinetics will be expressed by mathematical modelling. The project output will include a predictive model for the impact of ageing on Zn and Cu homeostasis, informing intervention with dietary advice or supplementation to improve longevity.  The consortium combines intersectoral and interdisciplinary expertise from 3 EU and 2 partner countries with established links and clear potential for knowledge exchange and transfer of skills. The consortium objectives are:1.       To determine the impact of dietary Zn and Cu on the microbiota and also age-related changes in the microbiota composition on the absorption of Zn and Cu.2.       To understand the influence of senescence on the regulation of Zn and Cu flux into and out of key cells controlling their homeostasis (gut mucosal cells, pancreatic acinar cells and hepatocytes) and its impact on the expression of related genes such as transporters.3.       To determine how senescence affects the trans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multi-sectoral, integrated and operational decision support system for sustainable use of water resources at the catchment scale (MULINO)' to be submitted under Fifth Framework.

assistant: **Abstract**

MULINO provides an operational Decision Support System (DSS) for the multi-sectoral assessment and simulation of human activities, to be used for the assessment and management of the sustainable use of water resources at the catchments scale. Concrete needs of end users, actively involved in the project since the design of the proposal, have contributed to design the DSS tool, integrating socio-economic and environmental modelling with a geographic information system.The application context is twofold:a) the support of water management in concrete decisional cases, andb) the assessment of water resources in representative European catchments. The dissemination of the results envisages local and international workshops, publications, multilingual newsletters, a web site and a final CD-Rom.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dendritic cell-based cancer immunotherapy targeting the tumour stroma' to be submitted under Sixth Framework.

assistant: **Abstract**

No effective therapy against adrenocortical carcinoma (ACC) is currently available, as is the case for most other solid carcinomas. Recently, new promising therapeutic approaches have arisen, such as immunotherapy based dendritic cell vaccination or targeting the tumour stroma. However, the first clinical trials targeting the tumour stroma with antibodies or small molecules were disappointing. Additionally, it is widely accepted that one treatment modality is not sufficient to cure cancer.The aim of this study is to combine two promising approaches, immunotherapy and stromal therapy into a novel approach whereby patients are vaccinated against products, which are preferentially over-expressed in the tumour stroma. Thus, we combine the advantages of a classical immunotherapy with targeting the tumour stroma, eliminating some of the inherent limitation of current antistromal strategy, offering an immunological treatment of minimal or no toxicity that should be applicable to almost all solid malignancies. Murine studies will test the hypothesis that an immunization with DC transfected with mRNA encoding tumour stroma antigens (e.g. FAP, MMP14) will inhibit tumour progression. In addition, synergistic effects of an immunotherapy targeting the tumour itself and the tumour stroma will be assessed. A preclinical in-vitro-study will test the capability to stimulate a specific cytotoxic T cell response in humans and will optimise the procedures clinical trials planned in patients with ACC.The first host is one of the pioneers in the field of dendritic cell based immunotherapy, Prof Gilboa, Duke University, USA. The proposed methods are well established in his laboratory. The second host is Prof Allolio, University of Wuerzburg, Germany. He is one of the leading researchers in th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The first process to synthesize Leather ‒ A fabric with the identical chemical composition and exact mechanical properties as leather' (GELATEX), addressing dissemination and exploitation.

assistant: **Impact**

Leather is a highly sought-after product for its very specific look, touch, feel and durability properties. It is considered a premium material in the fashion, upholstery and automobile industries. The leather production market, with an estimated value of €100 billion is projected to grow by 6.2% to 2023.  Sadly, the leather industry is one of the most polluting, due to the hide and skin tanning processes (excess water use, chemical spills, millions of CO2 emissions, worker health problems, skin diseases, filthy working conditions especially for women). Sustainability in leather production is a must in this day and age when eco-labels are sought after by brands to stand out from the crowd, as consumers demand higher quality standards. Currently, the one and only way to produce real leather is by taking the skin from an animal. Yes, alternatives like PVC and plant-based products exist, but their composition and properties are nowhere near that of real leather. Hence, they can never be adequate substitutes. At Gelatex, we have developed a cutting-edge new method of synthesizing layers of collagen, made from gelatin, creating a fabric of unprecedented quality, chemically equivalent to leather. Gelatex is the first to deliver this new animal-like leather without the need for tanning. The material is designed and configured following the industry requirements on tensile strength, resistance (to tear, to flexing, to puncture), good heat insulation, water vapor permeability and comfort. Ours is a scalable and efficient process allowing for Gelatex to be sold below the cost of current leather. We will can sell our tailor-made leather in colors thicknesses and sizes desired by our customers (manufacturers of leather articles). We thus expect to achieve revenues of €10 million in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Intelligent New Radio Access Network: Deployment and Management'.

assistant: **Innovation**

The fifth and sixth generations (5G/6G) of cellular networks have to handle an unprecedented surge in data traffic, which comes as a result of the emergence of a wide range of applications, notably, the Internet of Everything, haptic internet, digital-twin, to name a few. On one hand, mobile users expect to experience high-speed and reliable wireless access at an affordable cost. On the other hand, service providers aim at maximizing profits and are expecting cost-effective solutions from wireless industry.Increasing the capacity of the Next Generation Radio Access Network (NG-RAN) capitalizes in a part on reducing the cell sizes and the transmissions on high-frequency bands (e.g., millimeter wave) that offer small coverage. However, these solutions call for a dense deployment of base stations, where traditionally each comes with the expenses of establishing fiber links to the core network and a site acquisition (tower lease). The wireless industry leaders opt for developing flexible and more cost-effective NG-RAN that revolve around the dense deployment of low-cost radio access nodes with Integrated Access and Backhauling (IAB). The wireless backhauling/fronthauling feature will ease the task of IAB nodes deployment/relocation and save in the cost of the fiber-based bakchauling network. Although IAB is an attractive solution that could make dense deployments economically viable, efficient approaches for the optimization and management of the resulting large-scale and heterogeneous NG-RAN remain subject to investigation. Together with my supervisor Prof O. Ercetin, I will contribute to the efforts of building cost-effective NG-RANs empowered by IAB nodes, in particular, to the automation of the deployment, operation, and fast-recovery of NG-RANs. This project investigat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'European Conferences on Networks and Communications (EuCNC)'.

assistant: **Objectives**

It is the purpose of EuConNeCts, a Supporting Action, to organise the following 2 editions, 2014 and 2015, of the EC sponsored conference in the area of communication networks and systems.  The conference will be named EuCNC - European Conference on Networks and Communications.  EuCNC will serve as a technical and scientific conference for researchers, namely European ones, to show their work in the area of Telecommunications, focusing on communication networks and systems, but reaching services and applications.  However, the conference will not be restricted to European researchers, rather aiming at attracting others from all other regions in the world.  It will also serve as a showcase for the work developed by projects co-financed by the EC, namely those in Challenge 1 (Pervasive and Trusted Network and Service Infrastructures), and more specifically, those addressing Objective ICT-2013.1.1 (Future Networks), but aiming at attracting works in the area of communication networks and systems from other objectives.  EuCNC will: 1) be a European conference, but with a large international dimension; 2) showcase the R&D activities performed within EC programmes, directly and indirectly; 3) showcase the cooperation in R&D between European organisations and worldwide ones; 4) bridge between academia / research centres and industry; 5) coordinate its goals with the EC and the main European players; 6) be a high-quality R&D conference; 7) be a well-recognised conference in Telecommunications; 8) provide a forum for the presentation of state-of-the-art technology, in both theoretical and experimental forms; 9) communicate the research results to the wide audience of the general public; 10) foster the participation of both established researchers and students, as well as industr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Continuous loading of a mesoscopic dipole trap' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The recent achievements of laser cooling and manipulation of atoms as well as latest developments in atom optics have moved the whole field to the boundary of the new regime where coherent matter wave interactions will become dominant. After the realisation of Bose-Einstein-Condensation a next milestone will be the realisation of a laser like device for 'bosonic atoms', the atom laser. It is the objective of the project to set first experimental steps towards an atom laser by exploring and investigating continuous loading of a novel mesoscopic dipole trap. The project- including theoretical and experimental studies- will yield spin-off with respect to atom guiding, quenching of Penning ionisation, nanostructuring, atom lithography and atom microscopy The project will profit from the synergetic connection of my knowledge of laser physics with the knowledge in atom optics of e host institute, and will therefore stimulate the development of dipole traps and concepts for atom lasers in Europe Training content (objective, benefit and expected impact) Coming from the field of Quantum Electronics the project constitutes a change of subject and offers me the possibility to broaden my scientific skills and knowledge in the field of Atom Optics in particular and Quantum Optics as a whole. Due to the diversity of scientific work in the host institute I will gain state of the art knowledge on atom manipulation with lasers, laser cooling and trapping, and atom interferometery. I will present results of the work on international european conferences. Furthermore, I will profit from the active contact of the host institute with groups all around europe. In particular, short visits to the atom optics groups in Pans, Innsbruck and Oxford are planned .