RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bioprinting on-chip microphysiological models of humanized kidney tubulointerstitium' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Eight hundred and fifty million people worldwide are currently affected by chronic kidney disease (CKD), which is also the 11th leading cause of mortality worldwide.  CKD can occur from a multitude of causes including diabetes and high-blood pressure. Moreover, recent clinical and experimental studies have shown that CKD is closely interconnected with acute kidney injury (AKI) as well. Currently available in vitro models show limited relevance to study AKI, especially drug- and virus- induced AKI, due to the poor functionality and relevance compared to a diseased human tissue. BIRDIE aims at developing three-dimensional (3D) in vitro human renal tubulointerstitium (TI) models to enable viral infection and nephrotoxicity studies while creating a robust platform to address other diseases and treatment innovations in the future. Two enabling technologies, bioprinting and organ-on-chip, will be combined to build a microphysiological relevant TI model. Primary human cells and induced pluripotent stem cells will be used to generate kidney models, and combined with the aforementioned techniques model envisioning a reliable screening platform for future patient specific therapies. Our ambition is to create a new 3D renal in vitro model allowing an unprecedented degree of mimicry and function compared to a human kidney. While developing the model focusing on the applications mentioned before, our goal is to make it broadly applicable to the multitude of kidney-related diseases.


**Keywords:** Bioprinting, organ-on-chip, microphysiological in vitro models, BK polyomavirus, drug-induced toxicity, human cells, organoids
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Station for integrated services for operators and machine management' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The majority of companies in more advanced industrial sectors suffer limitations in their attempts to improve productivity as a consequence of the low operative availability which they are capable of obtaining from their production machines. The machines, many of which have a high level of automation and produce high added value and high responsibility parts, are rarely capable of attaining effective occupation ratios of more than 60%, especially in the production of single parts.The problem is particularly acute in strategic sectors such as the automotive, aeronautic and machine tools industries. The causes are diverse and well-known and include tool breakage, machine malfunctions, incorrect information, operator absence, maintenance work etc.In order to mitigate these problems, many commercial products are available. However, each of these only provides specific solutions to partial problems without resolving the overall problem. Based on this observation, SISOM aims at specifying, defining and implementing, the set of services necessary to a typical manufacturing environment in the aforementioned sectors in order to drastically reduce the causes of the non-availability of machines.All these services will be backed up with specific software to be developed over the project, capable of being run on low-cost computer platforms, with the final objective of ensuring the implementation and generalised use of these services in industrial plants cross sector.The implementation of these services will be structured around the figure of the operator as the element which brings together the aspects involved in the management of manufacturing means. Modern techniques of man-made interfaces based on the use of multimedia technology will be incorporated in its design.The product wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Prospective Memory in Mild Cognitive Impairment', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Population in Europe is ageing rapidly. Consequently, there is an urgent need to find ways to help the growing population of older people to live independent lives and preserve well being into old age. To address this pressing issue, PMinMCI will conduct the first systematic and innovative investigation of prospective memory in older adults at risk of Alzheimer’s disease. Prospective memory refers to remembering to do things in future (e.g., remembering to take medication or pay bills on time). Although it is a vitally important skill for one to function independently in everyday life, it has received so far little attention. The project will focus on: 1) identifying the prospective memory deficits that could serve as an early marker of cognitive decline and a predictor of dementia, 2) recognizing everyday memory problems of individuals in the transitional state between normal ageing and Alzheimer’s disease, and 3) proposing early psychological intervention aimed at reducing their anxiety and worry about memory. The expected results will allow practitioners to recognize opportunities for early intervention and help older adults in at-risk population maintain well being and independence in their everyday life as long as possible. The aims and expected outcomes of PMinMC perfectly fit the current and forthcoming research and innovation policy of the European Union. The project will also allow the Fellow to widen the scope of research conducted so far to include abnormal ageing and novel technology for conducting naturalistic studies with portable electronic (smartphone) eDiaries. It will also develop her ability to publish in top international journals, and establish a network of collaborators for future large-scale externally funded European and international research pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Hodgkin Lymphoma: Insights from genomic studies of mutations in coding and non-coding regions' to be submitted under Horizon 2020.

assistant: **Abstract**

Classical Hodgkin Lymphoma (cHL) is one of the most common cancers in young adults. While chemo-radiotherapy is effective, many patients continue to die of cHL or to suffer long-term treatment toxicities, such that more effective and less toxic drugs are needed. Studying the mechanisms underlying the puzzling biology of cHL (the only B cell-derived lymphoma loosing its B-cell identity) should illuminate its pathogenesis and possibly aid in developing better therapeutic strategies. In this project, I will study the function of mutations in the DNA binding domain of the STAT6 transcription factor, which the host laboratory identified as one of the most frequent genetic lesions in cHL. I will perform genome-wide ChIP- and RNA-seq studies to uncover aberrant gene expression regulation and occupancy by mutant versus wild-type STAT6 in cHL versus non-Hodgkin lymphoma (NHL) cell lines, and investigate their functional consequences at the cellular level. I will then express mutant STAT6 in germinal center (GC) B cells, the cHL cell of origin, to evaluate their role in early lymphomagenesis. Because genes mutated in cHL greatly overlap with those altered in NHLs, from which cHL is strikingly different, I will also explore whether unidentified mutations in non-coding regulatory regions may underlie the peculiar cHL pathogenesis. Recurrent somatic non-coding mutations will be identified through whole-genome sequencing of primary cases and will be annotated to the non-coding elements specifically active in cHL cell lines, which I will identify through RNA- and ChIP-seq for key histone marks. Finally, I will use appropriate techniques (e.g., genome topology and CRISPR editing) to assess how such mutations may alter regulatory networks important for cHL biology and identity. The proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Improving the quality and economic performance of cattle and the european leather sector through improved husbandry practice' (1998-2002).

assistant: **Innovation**

The European leather industry utilises a biological raw material by-product of the agriculture and meat sector, the hide. The quality of the hide is affected by on farm husbandry during rearing, particularly the infestation with the ectoparasite, lice. This damage, termed light spot, is estimated to reduce the value of European hides and subsequent leather by 300 million Euros per annum, due to lost potential, increased processing costs and chemical usage. Control of lice infestation would have a significant impact on the competitiveness of the European industry, which is predominated by SME' s who, as such, are unable to invest the relevant resources into addressing such problems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'HEART Rating for Objective Neural Intelligent Communication (HEARTTRONIC)' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Cardiovascular diseases (CvD) cause the death of around 4.500.000 people per year in Europe, being the first cause of deaths in Europe. The challenge of the HEARTRONIC project is to provide a real;, solution for continuous monitoring and real time prevention, by means of early warning, to people already diagnosed as subject at high risk. A solution to allow patients to go on with a normallife, meantime increasing their expectation of life and improving quality. The intention of the Heartronic project is not to re-design the cardiology science, but rather to analyse all medical and patients' requirements, to exploit the various existing and promising technologies relevant to this area, and integrate them with innovative and not invasive technologies for a reliable and safety tool that really responds to the demand of doctors and patients, increasing the expectation of life and significantly improving the quality of life, specially concerning the weakest categories of population like: children, patients waiting for heart transplant, infarctuated patients suffering from chronic depression, elders, disables.Furthermore The Heartronic system will be able to record any hearth anomaly in real time, early warn the doctor in charge and allow the patient's localisation by the GSM system; the doctor in charge, received all data either on his PC or mobile phone, will be able to carry out a timely diagnosis, deciding as well the most appropriate intervention to the patient, maybe unaware of his conditions. If the doctor will not be reachable, all data will be sent to a Host server that will manage the emergency in the way explained above. From a technical point of view, the relevance of transnational co-operation is due to the high degree of multidisciplinary character of the intend
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Emergency Decision Support System of Offshore Platform Fires' in the context of a Horizon 2020 call.

assistant: **Objectives**

In this project, fire accidents on offshore oil and gas platform will be analysed to identify the typical fire scenarios, followed by numerical simulation on the temporal and spatial evolution of the fires. Secondly, the coupling mechanism between human behavior and fire development will be investigated to quantitatively characterize the impact of fire on people and other assets. Thereafter, based on fire numerical simulation and multi-agent theory, an evacuation simulation model of offshore platform fires will be proposed. Thirdly, the dynamic risk of offshore platform fire evacuation will be evaluated by considering both failure consequences and their probabilities. A risk warning model of offshore platform fire evacuation will be built based on the Wavelet Genetic Neural Network. Finally, a dynamic decision-making support system for fire emergency evacuation will be designed by integrating Computation Fluid Dynamic (CFD), multi-agent theory and the Virtual Reality (VR) technology. This project covers a wide range of disciplines including CFD, multi-agent-based evacuation simulations, probabilistic inference (Bayesian inference and system dynamic model) and the VR technology. This Individual Fellowship will significantly accelerate the development of interdisciplinary knowledge, innovative research skills and new career of the nominated Fellow.


**Keywords:** Offshore safety, fire analysis, offshore platforms, decision making
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Romebimeden' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Our understanding of the importance of metals in biology and medicine has become increasingly apparent in the last twenty years. To take two simple illustrations: the movement of electrons in the respiratory chain, accompanied by proton pumping would be impossible without iron in cytochromes and in iron-sulphur proteins; the toxicity of lead (causing saturnism, particularly among young children in socially deprived inner cities) finds its molecular explanation in the extraordinary high affinity of Pb (binding constant of 10 15 M) for a key Zn-dependent enzyme of haem biosynthesis. Europe has been in the forefront of this research effort, with the first three ICBICs (International Congresses on Bio-Inorganic Chemistry) taking place in Europe (Italy, Portugal and Holland). Appropriately, this year, the tenth ICBIC meeting will again be held in Forence (with typically around 1000 participants). It has been clear from the outset that the study of metals in biological systems can only be approached by a multidisciplinary approach, involving many physical and biological sciences. Today, in addition to their importance in biology (and medicine), we are increasingly aware of the role of metals in the environment, not only as pollutants (Pb, Hg, Cd), but also as essential components of a healthy external milieu (requiring numerous trace metals). In order to ensure that Europe maintains its position in this important area, not only with its scientific implications, but also with its social impact, we need to train young scientists at the interface between physics, chemistry, biology, medicine and environmental sciences.This has been successfully done over the last 15 years, and we are confident that the EC will recognise the importance of this activity in supporting our effort on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'BRINGING DOWN BARRIERS TO CHILDREN’S HEALTHY EATING' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Edulia responds to the urgent need of EU society to find new ways to tackle the escalating issue of obesity, through promoting healthier eating from childhood. Based on the relations of sensory perception, pleasure, food choice and food behaviour, the project will look for new approaches to drive children to like and actively choose healthy foods, developing healthier habits. Edulia is a multi-disciplinary and inter-sectorial European Training and Research Network with a global reach. Our network will train a new generation of innovative and adaptable researchers, with highly specialised skills across complementary fields studying children’s food choice, while exposing them to cross-sector experiences, in order to build strong career development paths. The training program includes multidisciplinary scientific training within natural and social sciences, secondments in academic and non-academic organisations, and courses in transferable skills, promoting science communication and outreach. The overall aim of the research programme is to better understand how multiple factors act as barriers for children’s healthy eating and how to tackle them, bringing together leading scientists in the Food Choice arena in a collaborative network that will transcend the limits of this project and strengthen European research. Edulia will go further than the classical approach of “teaching children what is healthy”, by exploring approaches such as positive marketing, nudging strategies, focusing on peer and family social interactions, studying sensory and non-sensory parameters that influence what is eaten (food choice) and how much is eaten (intake), and exploiting the positive food sensory characteristics which can drive healthy eating through enhancing pleasure. We will ultimately pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Targeting ubiquitin processing in cancer and fibrosis: novel probes for the Ubiquitin Carboxy-Terminal Hydrolases' under Horizon 2020.

assistant: **Concept**

Modification of proteins with ubiquitin (Ub), itself a small protein, is a fundamental mechanism involved in regulation of almost all cellular functions. There are hundreds of enzymes involved in the addition or removal of Ub, and this system has emerged as an important drug target in many diseases. Ubiquitin Carboxy-Terminal Hydrolase L1 (UCHL1) is a member of the UCH family of deubiquitinases (DUBs), and is the most abundant protein in the brain. UCHL1 dysregulation has been shown to be associated with neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, various types of cancers (colorectal, breast, prostate, ovarian, and lung cancers), and liver fibrosis. However, its actual functions, endogenous substrates, and how its activity is regulated in vivo, both in pathological and healthy tissues, remain poorly understood. To overcome these limitations and to realize the unmet therapeutic opportunities, I will develop and synthesize activity-based probes to selectively target UCHL1, and will apply them to the identification and quantification of UCH enzymes in several cancer cells using activity-based protein profiling. This will provide a unique tool to explore a wide range of DUBs and UCH biology in cells, as well as a starting point to develop selective inhibitors and potential therapeutics.Simultaneously, I will develop and synthesize irreversible PROTACs to selectively degrade UCHL1 and will apply them to quantitatively assess their effect on UCH enzymes in several in vitro cancer and fibrosis models using proteome-wide proteomics experiments. PROTACs are two-headed molecules capable to direct E3 ubiquitin ligase activity towards the target protein, driving its degradation by proteasome. I anticipate that novel PROTACs based on inhibitors tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'T i between rnap ii prom' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Termination of transcription defines the actual end of a gene and is mediated by signals involved in 3' end processing of the nascent RNA transcript as well as additional downstream elements. Deletion of these terrnination signals can lead to interference between adjacent genes resulting in impairment of expression of the downstream gene. This suggests a key role for termination in the regulation of gene expression. Interference has been observed in a number of genetic systems and represents a serious problem in the design of vectors for gene therapy. In the first year of my PhD, I have investigated the biological role of interference by studying the effect of placing two genes (transcribed by RNA polymerase II) in close proximity in a chromosomal context. Using such constructions I have studied the molecular basis of this mechanism by directly characterising the effect of interference on the binding of transcription factors to the downstream positioned gene. I now intend to define more completely the general significance of this mechanism in genetically tractable yeast systems.