RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Implementation of Risk Governance: meeting the needs of nanotechnology' under Horizon 2020.

assistant: **Concept**

Gov4Nano will design and establish a well-positioned and broadly supported Nano Risk Governance Council (NRGC). Organizing, connecting and engaging are key activities in Gov4Nano and its creation of a sustainable NRGC. Gov4Nano will develop an operational trans disciplinary Nano Risk Governance Model (NRGM) for nanotechnologies, building on an established governance framework developed by the International Risk Governance Council (IRGC). Engaging stakeholders (including regulators) to proactively address nano-specific safety and seek dialogue for joint activities. NRGC and its precursor project Gov4Nano will engage, in order to support these activities, with the broad variety of stakeholders across all relevant nano-disciplines (chemical, biocides, food and feed, pharma and medical devices and materials development) and draft a review on our knowledge progress over the last decade whilst initiating dialog. To boost the quality of the dialog it will create a platform for dialogues between stakeholders in a “trusted environment” inclusive of civil society.The NRGC core business is to coordinate, guide and harmonize in order to overcome the fragmentation of current knowledge, information and needs over various sectors and disciplines (workers, consumers/patients, environmental safety) and to prepare the transfer of this knowledge.To that end, the NRGC will be equipped with a self-sustainable NanoSafety Governance Portal (NSGP) consolidating state-of-the-art and progressive nanosafety governance tools including ones for dialogues and measuring risk perception. Major efforts will be towards requirements for data harmonization and data curation to be defined and laid down in guidance on obtaining harmonized and standardized quality-scored data collections promoting a big data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a multiplex polymerase chain reaction test for the s imultaneous detection of four sexually transmitted infections' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

chlamydia trachomatis, Neisseria gonorrhoeae. Trichomonas vaginalis and mycoplasma genitalium are inadequate. Meanwhile molecular biology-based methods for the identification of these organisms offer significant advantages. Yet, the acceptance of these molecular tests has been delayed due to their higher cost which is beyond the reach of national health care budgets and by the lack of a molecular test for gonococall antibiotic resistance.   Inherent in a molecular technique called the polymerase chain reaction (PCR) is the ability to combine related assays into a single multplex reaction with little increase in cost.  This application proposes the development of a multiplex PCR test for the above noted organisms thereby reducing the cost of each component assay to a cost comparable with conventional technologies. Further, the first multiplex PCR will be combined with a second designed to detect four genes/mutations responsible for antibiotic resistance in N. gonorrhoeae, thereby increasing the clinical utility of these tests. Both multiplex reactions will be designed with a fluorometric analysis system to facilitate their execution in an automated format.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Elucidating the nano-biointeractions on DNA origami' (ORBIT) targeting Horizon Europe.

assistant: **Abstract**

The forces governing the nano-biointeractions are essential to understand the biological behaviour and pharmacokinetics of the nanostructures. So far, these understandings have been limited to nanoparticles. However, it should be noted that the NPs chemical synthetic methods render non-homogeneous dispersions, even when low polydispersity is reached. In addition, the modification of NPs with a specific number of ligands is still challenging and there is no agreement about the most effective configuration or number of ligands to achieve efficient targeting in vivo. The programmability of the DNA-nanostructures (origamis) allows the synthesis of predictable and controllable sizes and shapes with almost atomic precision. In addition, the origamis can also be designed to include additional molecules, with high accuracy on the valency and the orientation. Thus, this technology offers a powerful tool to study and understand the biological behaviour of objects at the nanoscale since precise control over the size, shape and attachment of molecules can be achieved when other methods are unable to. Based on the structural organization and spatial distribution of natural and specific bionanoparticles, such as viruses, this project will exploit the atomic programmability of origamis to design a library of DNA nanostructures inspired on viral particles. The biomolecular corona will be studied to understand its impact on origamis biodistribution, a topic still not studied yet. Finally, the cell response will be evaluated in terms of targeting and immune response. These results will help to a better understanding of the mechanism between nano-structures and living systems and to formulate guidelines to synthesize more efficient nanomedicines. Overall, this project will allow me to car
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Smart Ultraviolet Radiation Filters' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Over 3M new cases of skin cancer occur annually, with 85% related to sun exposure, hence widely preventable. Sunscreens are key players for skin cancer prevention protecting us from the UVR due to their active ingredients: UV filters. Regrettably, existing filters have limitations: Fast degradation; Toxic to humans/sea environment; Limited exposure time; Require combination of multiple filters for full UV spectrum protection. Roka Furadada has developed and patented SMART UV overcoming all those limitations: non-toxic, long-lasting, UVR-dose dependent and eco sustainable (lignin as raw material) promoting circular economy. Our goal is to make SMART UV the first choice for sunscreen manufacturers and users that wish to protect their skin without harming the environment. The EIC Acc will help bring SMART UV to market, optimizing scalability, sustainable synthesis, completing lab tests, and obtaining cosmetic ingredient certifications. Roka expects to breakeven by 2024 with sales of 4M.


**Keywords:** photochemistry,skin cancer prevention,cosmetics,UV filters,sunscreens
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Custom-Made Designer Macrophages to Revolutionize the Safety of Parenteral Drugs', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The iPYRO proposal is built upon the uniqueness of human induced pluripotent stem cells (iPSC) and recent innovations in the farming of fully defined human macrophages (iMonoMac) using industry compatible bioreactors. Given the growing need for industrial macrophages, iPYRO sets an innovation in the forefront of drug safety evaluations, supplying a unique cell type, which meets the expectations from industry and regulators. The breakthrough innovation of iPYRO will offer a superior, thus highly standardized, economically produced and fully validated off-the-shelf macrophage-based cell product to revolutionize the safety of drugs and beyond. To maximize the outcome, iPYRO will assess the regulatory compliance, while further streamlining the iMonoMac product for the envisioned spinout, establishing a proper freedom-to-operate strategy and a suitable business model. The seminal iMonoMac platform along the unique IPR and established contacts to industrial and regulatory stakeholders will pave the transition from academia to industry, introducing for the very first time an iPSC-cell product for the drug safety market market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Rhodium-catalyzed carbyne transfer strategy to streamline synthesis of housane' in the context of a Horizon Europe call.

assistant: **Objectives**

Aliphatic sp3-rich ring systems such as cyclopropanes and cyclobutanes are commonly observed motif in drug molecules. This is due to the fact that they can positively influence metabolic stability, conformation, pKa, entropy, membrane permeability or pharmacokinetics in drug leads. However, the molecule consists of a cyclopropane fused to cyclobutane, traditionally known as ‘housane’ is significantly underexplored and yet to appear in drug molecules. This can largely be attributed to the lack of general synthetic methods for the preparation of this motif.  Current protocols for the synthesis of housane, require multistep manipulations or pre-functionalized substrates, which means low efficiency and sustainability. Housane aims to develop an innovative technology to rapidly construct housanes and housane derivative of drug molecules from feedstock and fine alkenes based on a Rh-catalyzed carbyne transfer platform. A key strength of this conceptually new and multidisciplinary proposal is the introduction of a secondment phase in Janssen (Toledo, Spain) to explore real-life applications. The ambitious action merges perfectly with the expertise of the host in novel C-H and C–C bond functionalization strategies based on the catalytic generation of carbyne equivalents with the strong background of the applicant in transition metal-catalyzed asymmetric allylic substitution chemistry, thus enhancing two-way transfer of knowledge between the ER and the host group. This project will expose the fellow to a wide range of cutting-edge chemistry including medicinal chemistry in an interdisciplinary and international environment (ICIQ, Janssen) and enable the fellow to become a leader for the next generation in the field of organic synthesis, homogeneous catalysis and medicinal chemis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Takeafile: A peer-to-peer online platform to transfer files of any size at maximum speed and in a secure way.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Takeafile is a disruptive service that will allow professionals to channel all their data transfer needs in a single platform, so they can send files faster than with the alternatives (up to ten times faster), without size limitation of the files sent and in a purely confidential way. To this end, Takeafile distinguishes itself from the sharing services proposing a unique way of sending files without the need of intermediate servers, using a peer-to-peer transfer strategy, where the file goes direct from one computer to another computer, using the shortest way.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'OPERATIONALISATION OF NATURAL CAPITAL AND ECOSYSTEM SERVICES: FROM CONCEPTS TO REAL-WORLD APPLICATIONS' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Despite improved understanding of the links between ecosystem health, provision of ecosystem services and human well-being, further conceptual and empirical work is needed to make the ideas of ecosystem services (ESS) and natural capital (NC) operational. OpenNESS will therefore develop innovative and practical ways of applying them in land, water and urban management: it will identify how, where and when the concepts can most effectively be applied to solve problems. To do this, it will work with public and private decision makers and stakeholders to better understand the range of policy and management problems faced in different case study contexts (ranging across locales, sectors, scales and time). OpenNESS will consolidate, refine and develop a range of spatially-explicit methods to identify, quantify and value ecosystem services, and will develop hybrid assessment methods. It will also explore the effectiveness of financial and governance mechanisms, such as payments for ecosystem services, habitat banking, biodiversity offsetting and land and ecosystem accounting. These types of interventions have potential for sustaining ESS and NC, and for the design of new economic and social investment opportunities. Finally, OpenNESS will assess how current regulatory frameworks and other institutional factors at EU and national levels enable or constrain consideration of ESS and NC, and identify the implications for issues related to well-being, governance and competitiveness. OpenNESS will analyse the knowledge that is needed to define ESS and NC in the legal, administrative and political contexts that are relevant to the EU. The work will deliver a menu of multi-scale solutions to be used in real life situations by stakeholders, practitioners, and decision makers in public
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'How our adaptive immune system separates “self” from “foreign” – a physicochemical study of binding in cell contacts'.

assistant: **Objectives**

How can our immune system efficiently fight foreign pathogens at the same time as it is selective enough to leave our own cells alone? This, so called antigen discrimination, is still not understood on a molecular level. I will here illuminate this question by developing a physicochemical understanding of how T-cell receptors (TCRs) bind peptide-loaded major histocompatibility complexes (pMHCs), and importantly, how this differs for pMHC displaying self and foreign peptides. The interaction between TCRs and pMHCs on contacting immune cells is the first step in initiating an adaptive immune response. However, binding between membrane-anchored TCR and pMHC is a challenging physicochemical problem that has not been solved, and the binding kinetics is strongly affected by the membrane. Well-controlled measurements between TCR and pMHC under relevant conditions are needed to better understand the TCR/pMHC kinetics. A key discovery to achieve this is a method recently developed by me, which allows for extremely weak protein-protein interactions in contacting cells to be measured. I will in this project, backed up by immunologist in Oxford and theoretical chemists in Lund, build on this breakthrough and for the first time measure the binding kinetics between TCR in model cell membranes and pMHC on single cells, and how binding varies between self and foreign pMHC. Parameters such as adhesion molecules, applied force on the bond, the co-receptor CD4 and TCR clustering are all crucial for proper T-cell signalling, but their influence on the TCR/pMHC binding kinetics is unknown, and will here be studied. The obtained data will finally be used to evaluate, and improve on, kinetic models of antigen discrimination. Complemented with molecular dynamics simulations this altogether ope
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transfer and industrialisation of extraction process by controlled instantaneous pressure drop (détente instantaneé controleé (DIC)")"' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

This project aims at the transfer of the new process of extraction by controlled instantaneous pressure drop DIC to the perfumery, food cosmetic and pharmaceutical industries.This technology was the subject of a long research program at the laboratory LMTAI which ended in the definition of a new process of extraction of essential oils and improvement of the extraction capacity of heavier components, e.g. extraction made by pressing, centrifugation or by means of solvents.This process is characterised by its capacity to couple the very high extract quality (absence of thermal degradation, improvement of the technological aptitudes e.g.) with a low cost. It is also a very friendly process to the environment. However, a good scaling-up requires a more precise activity concerning the process, technology, semi-industrial scale equipment, and also have the extracted material itself (perfume, wood, terpene, pectin, oil of fish, juniper, sesame cream, bioflavonoids from grape juice and pip, coconut mils, tea olive oil e.g.).The industrial partners, both the users and the equipment suppliers, will gain a strategic technological advantage making them much more competitive.The technology itself will provide totally novel and low price extraction processes to many different industry sectors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Improved salting process for demersal white fish' (1994-1998).

assistant: **Innovation**

The aim of the project is to optimise the salting process of demersal white fish from fresh raw material to ready to serve product for the consumer. The main concern for the producers today are yield, quality (unpredictable variations) and safety of the products. In this project, the effects of different parameters in the process on the microstructure of the fish muscle will be studied through the whole process by using a new image processing technology. These results in addition to sensory, chemical and physical methodology will be used to understand and optimise each process operation (presalting, soaking, drying), in context to the whole process.The production of salted fish in old days was needed for preservation of this commodity during transport and sales in countries far from the rich fishing grounds in the North Atlantic. Nowadays the product has become a traditional part of the ethnic consumption habits in many of the Mediterranean countries. The need to preserve the fish by salting and/or drying is not the driving force anymore-rather the character such as taste of the product. This has developed into an important culinary tradition in countries like Spain and Portugal. The salted cod-fish (Bacalao) has great potential for further product development to meet the evolving need of the modern consumers that demand more easy to use products. The dried salted fish is not exactly that consumer friendly, as it needs 13 days of preparation before cookingThe project proposal will address the process and distribution of the salted fish through the chain from the rural fishermen in Iceland to processors located in rural areas in Spain and Portugal and to the end consumer. The project will be executed by institutions and SME's in those three countries.The project is divid