RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Diabetes: pericyte-orchestrated islet inflammation as a driver of beta-cell failure' (2021-2027).

assistant: **Innovation**

Type 2 diabetes (T2D) has reached epidemic proportions, killing millions each year; however, our incomplete understanding of its etiology hinders the quest for a cure. T2D is caused by pancreatic -cell failure and insulin resistance. Recent studies point to aberrant islet inflammation as a driver of diabetes. While inflammation is beneficial for insulin secretion during homeostasis, it may transform to harm -cell function and impair the glucose response. How islet inflammation maintains glucose homeostasis and why it converts to being destructive remain largely open questions. Here, I introduce a novel physiological mechanism, pericyte-orchestrated islet inflammation (PIIN), which is disturbed by diabetes risk factors to cause -cell failure. To establish its requirement for -cell function, we will first define the role of PIIN in homeostasis. We will then determine how T2D environmental risks, such as obesity and aging, hamper pericyte cytokine production and transform islet inflammation to cause -cell dysfunction. Lastly, we will link T2D genetic risk factors with aberrant PIIN. To this end, we will analyze human and mouse tissues and use transgenic models to manipulate cells and genes to define the effect of PIIN on -cell function. Ultimately, our findings will provide a mechanism through which T2D risk factors induce -cell failure and promote disease progression. The implications of this project are far-reaching, as they will introduce a novel cellular mechanism that integrates metabolic and genetic risks to cause diabetes. Furthermore, our findings will implicate PIIN as a novel target for new therapeutic approaches to diabetes.


**Keywords:** Pancreatic beta-cells,  Pericytes,  islet inflammation,  transgenic mice,  Type 2 diabetes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Programming Model INTERoperability ToWards Exascale (INTERTWinE)' to be submitted under Horizon 2020.

assistant: **Abstract**

This project addresses the problem of programming model design and implementation for the Exascale. The first Exascale computers will be very highly parallel systems, consisting of a hierarchy of architectural levels. To program such systems effectively and portably, programming APIs with efficient and robust implementations must be ready in the appropriate timescale. A single, “silver bullet” API which addresses all the architectural levels does not exist and seems very unlikely to emerge soon enough. We must therefore expect that using combinations of different APIs at different system levels will be the only practical solution in the short to medium term. Although there remains room for improvement in individual programming models and their implementations, the main challenges lie in interoperability between APIs. It is this interoperability, both at the specification level and at the implementation level, which this project seeks to address and to further the state of the art. INTERTWinE brings together the principal European organisations driving the evolution of programming models and their implementations. The project will focus on seven key programming APIs: MPI, GASPI, OpenMP, OmpSs, StarPU, QUARK and PaRSEC, each of which has a project partner with extensive experience in API design and implementation. Interoperability requirements, and evaluation of implementations will be driven by a set of kernels and applications, each of which has a project partner with a major role in their development. The project will implement a co- design cycle, by feeding back advances in API design and implementation into the applications and kernels, thereby driving new requirements and hence further advances.


**Keywords:** Exascale, interoperability, programming models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Fifth Generation Communication Automotive Research and innovation'.

assistant: **Innovation**

There are two ongoing industrial trends, one in the mobile communications industry and one in the automotive industry, which are becoming interwoven and will jointly provide new capabilities and functionality for upcoming intelligent transport systems and future driving.The automotive industry is on a path where vehicles are continuously becoming more aware of their environment, due to a permanent increase in various types of integrated sensors; at the same time the amount of automation in vehicles increases, which – with some intermediate steps – will eventually culminate in fully-automated driving without human intervention. Along this path, the amount of interactions increases, both in-between vehicles, as well as between vehicles and an increasingly intelligent road infrastructure. As a consequence, the significance and reliance on capable communication systems for vehicle-to-anything (V2X) communication is becoming a key asset that combined with sensor-based technologies will enhance the performance of automated driving and increase further traffic safety.On the other hand, the mobile communications industry has over the last 25 years connected more than 5 billion people and mobile phones have become part of our daily living. The next step in wireless connectivity is to connect all kinds of devices that can benefit from being connected, with a total of 28 billion connected devices predicted until 2021. It will support the transformation of industries on their journey of digitization. In this step, mobile communications has the ambition to explicitly target the communication needs of vertical industry with corresponding requirements being set for the standardization of 5G until 2020.5GCAR brings together a strong consortium from the automotive industry and the mobil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Implementation of Advanced Digital Solutions to increase the circularity of PV panels throughout the full value chain.' (SOPHIA), addressing dissemination and exploitation.

assistant: **Impact**

SOPHIA addresses to the problem of photovoltaic panels End of Life, their management and the society awareness on electronicwaste management. The project will implement several Advanced Digital Solutions, involving all actors in the value chain, in order toincrease the reuse and repair rates of these products. For the evaluation of the State-of-Health and dismantling of PV panels, a roboticprototype based on IA model will be created. In cases where it is not possible to repair and reuse the PV panels , they will recycled by shredding sorting, and specific upcycling processes for each byproduct."", Because of their traceability and information available in the Digital Product Passport (DPP), the panels will be easily identifiable,hence the PV panels will be recycled by type and composition, increasing the quality of the obtained secondary raw materials, thusreducing waste generation. The repaired panels and secondary raw materials will be put up for sale on a marketplace, with the aim that all these products that are marketed have traceability provided by the DPP. Furthermore, in order to achieve goals and high circularity for thepanels in the long term, an eco-designed and easy dismantling solar panel will be developed as prototype. It is expected that in thelong term, the project will help to increase social and corporate awareness about the panel production impact, aiming towards a fullecodesign practise fully sustainable PV industry. Additionally, SOPHIA will contribute to the generation of new marketsaround the photovoltaic sector across Europe.""


**Keywords:** PV panel, Solar panel, Digital product passport, Advanced Digital Solutions, Upcycling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Understanding diversity in decision strategy: from neural circuits to behavior' to be submitted under Horizon Europe.

assistant: **Abstract**

The brain has the remarkable ability to imagine diverse solutions to complex problems and to rapidly switch between them to adapt to new situations. Such properties are essential for adaptive behavior but remain poorly understood, partly due to the prevalent focus in previous studies on stereotypical behaviors. Here, we will adopt a fundamentally different approach by exploring the neural properties underlying diversity in decision strategy, aiming to provide greater insights into how the brain operates in natural conditions.By leveraging novel computational methods that identify changes in behavioral strategy combined with the latest advances in electrophysiological recording and optical manipulation in mice, the overarching goal of the project is to understand how the brain switches between different decision strategies. We hypothesize that the brain achieves remarkable flexibility by running multiple decision processes in parallel, allowing animals to select one decision strategy while their brains maintain several alternative solutions readily available for quick adaptation. We will test this hypothesis through a series of experiments that aim at determining:(1) Which neural circuits are involved in strategy selection?(2) What neural mechanisms control changes in strategy?(3) How to trigger a strategy in neural circuits and behaviors?We will address these questions using mice in the context of foraging, a fundamental survival behavior shared among all animals, involving the search for resources in dynamic environments. The project will deliver a rich and unique neural and behavioral dataset, enabling the development of a novel conceptual framework for behavioral flexibility as an adaptive selection mechanism of parallel decision computations. Ultimately, this resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Next Generation Supply Chain Management Software in the European Food Industry - NexGenFSCM' to be submitted under Horizon 2020.

assistant: **Abstract**

Retail Logistics Excellence - RELEX Oy is a Finnish company that has built an innovative supply chain management solution for demand forecasting, inventory optimisation and automated replenishment for manufacturers, retailers and wholesalers. Unlike traditional supply chain management solutions, RELEX’s solution is built on a unique columnar in-memory database and uses optimisation algorithms based on the supply chain research of the company founder. As a result, it is less costly, more flexible and much faster than traditional disc-based solutions. The objective of the innovation project is to increase the efficiency and reduce the spoilage of the food value chain companies by introducing an innovative and disruptive supply chain management solution for food retailers and wholesalers. When launched, RELEX’s solution will be the only one in retail and wholesale sector that is wholly built on in-memory calculation and analysis and offered to food retailers and wholesalers as a costeffective and innovative SaaS (software as a service) solution over cloud. In addition to the performance leap that the solution enables, with the new forecasting methods food retailers and wholesalers will be able to produce better and more accurate forecasts that result in reduced inventory levels, increased sales and decreased spoilage. The market potential for RELEX’s solution within food retail and wholesale sector is estimated to be valued at 1,2 billion euros globally and 420 million euros in the EU. As a financial result of the innovation project, RELEX aims at generating additional annual turnover of 85 million euros from the food retail and wholesale sectors the by the end of 2020. This represents 20 % of the sector’s estimated market potential in Europe. The proposed project is a str
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Improvements of particle image velocimetry applied to turbulence analysis influid mechanics' under Fourth Framework.

assistant: **Concept**

Research objectives and content Digital Particle Image Velocimetry (D-PIV) is the digital counterpart of conventional Laser Speckle Velocimetry (LSV) and Particle Image Velocimetry techniques. In this novel two-dimensional non intrusive technique, digitally recorded video images are analysed computationally, removing slow and opto-mechanical processing steps. Depending on the procedures adopted to analyse the PIV images the performances of the whole technique can vary dramatically. The accessibility in terms of cost, to more powerful computers makes it possible to develop very accurate processing techniques that are leading the technique to the top of the advanced experimental, non-intrusive, tools for quantitative multidimensional measurements. It is worthwhile to remember that the more accurate are the results of a measurement, the deeper basic fluid dynamics phenomena like instability, turbulence and combustion can be understood. The major need for this improvement is represented by the fact that most of the flows of current interest in basic and applied research fall in the mentioned examples. The aim of the present co-operational project consists, mainly, in the development and improvement of innovative D-PIV procedures, making use of the powerful computational resources. The plan will be to apply 'intelligent algorithms' imported from the area of Computational Fluid Dynamics (CFD). The experimental results are expected to represent an important test bench for CFD itself, considering that the actual state of the art in such field does not allow jet to simulate correctly turbulent flows as well as turbulent combustion. Training content (objective, benefit and expected impact) The research program to be made at the von Karman Institute offers the possibility of utili
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Gamma-Neutron Vision aimed at improved cancer treatments in Hadron Therapy', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Proton therapy represents one of the most recent and adavanced tools in cancer treatment, especially for complex cases and pediatric patients. Despite its exponential deployment worldwide, hadron therapy still faces two main limitations, which are related to: i) accurate ion-range verification and ii) assessment of the secondary (unwanted) neutron dose. The present proposal presents an innovative tool, that can help to improve this situation and thus increase the potential benefits of hadron therapy. This project focuses on a portable device, that can simultaneously image both gamma-rays and thermal neutrons, which are ineluctably produced during the treatment. On one hand, imaging thermal neutrons may help to quantify more reliably the secondary neutron dose received by the patient during therapy. Complementary gamma-ray imaging is accomplished with the same apparatus by means of electronic collimation, thus enabling real-time assessment of the ion-range. In terms of gamma-vision, the system has been recently tested in pre-clinical conditions at CNA-Seville and HIT-Heidelberg. This POC project aims therefore at demonstrating the additional neutron-vision capability, thereby elevating the full GNVision system to TRL6, and addressing its commercial viability in the health-sector.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sustainable development at local and regional levels: methods and techniques to support Ecosites and monitor urban sustainability' under Sixth Framework.

assistant: **Concept**

Specific Objectives:Ecosites Component;1. To write the specification of a European standard for Ecosites and to provide Technical Guidelines for Ecosites creation;2. To support the communication and networking between Ecosites in order to develop and exchange best practices;3. To identify, compare, develop and compute spatial indicators of sustainable development at local level;4. To provide training for the implementation of new Ecosites Sustainable Urban and Regional Development Component;5. To identify, develop and compute spatial indicators of sustainable development at urban and regional scale for comparison and benchmark at EU level;6. To develop reference methods for impact assessment and impact scenarios on urban and regional development. Impact scenarios will take into account the development policies in the framework of urban and regional sustainability in order to compile technical guidelines for reporting;7. To support the definition and preparation of the Urban Thematic Strategy by leading the Working Group on Sustainable Urban Management and to complement the Research Programme of the European Spatial Observatory Network (ESPON) by interfacing with the related individual research topics (urban, polycentrism, transport, accessibility etc.) and co-ordinating the ESPON research teams in order to ensure methodological consistency across the topics. Possibilities to extend the geographical scale of the JRC work (namely Moland in FP5) will be investigated. The results of pilot project in Northern Ireland (done in coordination with DG REGIO C.1) will be presented and included into the ESPON research programme. Anticipated milestones and schedule February 2003: First Thematic Strategy Annual Platform (Concept and Priorities) February 2003: Draft Table of contents
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Preventive and Personalised Remote Care for Heart Patients' under Horizon 2020.

assistant: **Concept**

There is no cure for chronic heart disease. Instead, it is crucial to detect early signs of worsening and to manage the disease over time. Even when chronic heart patients have cardiac implanted electronic devices (CIED), dangerous arrhythmia still occur and leads to early deaths and dramatically reduce patients’ quality of life. Today, hospitals carry out partly remote follow-ups on these life-threatening situations. But current systems are disease oriented (focus is on managing symptoms, not preventing them) and are designed for reactive care (only intervene after symptoms have manifested and unable to predict arrhythmia).Vital Beats has developed a state-of-the-art patient-centered, AI-driven clinical decision-support tool (SCAUT DECISIO) for preventing life-threatening arrhythmia in CIED patients. By combining patient-clinician communication with predictive AI algorithms, we can effectively and efficiently predict life-threatening arrythmias up to 30 days in advance, thereby allowing early and appropriate interventions to be taken. SCAUT DECISIO minimizes the number of CIED patients experiencing life-threatening arrhythmia – and eventual death – by 20%. This results in (1) improved quality of life for patients, (2) improved quality of care, and (3) reduced healthcare costs. SCAUT DECISIO will revolutionise chronic care and finally enable truly personalized and preventive care for chronic heart patients.To date, Vital Beats has raised more than €4M in total funding to bring the pilot product to its first test at the Heart Centre at Rigs Hospital in Denmark. The EIC Accelerator will be a key de-risking step, which will enable Vital Beats to validate their platform, obtain regulatory approval needed to be ready for global commercialisation. Vital Beats seeks €2.38M to