RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Nett-shape manufacturing of tubular c omponents'.

assistant: **Concept**

Summary: Currently available routes for the precision forming of geometrically complex industrial components, requires the material to be subjected to forming operations with a sequence of die-cavities, and often on different machines. This approach does not present substantial opportunities for the improvement of productivity. The proposed injection forging approach enables the complete forging of tubular components in a single station. To-date the practicable range for the injection forging of tubes has been somewhat limited due to folding failures appearing in the tube wall, but comprehensive research in the mechanics of the injection forging process, carried out by the applicant, has revealed that pre-forming of a geometrically simple inner flange on the tube, prior to injection forging, allows a considerable extension of these forming limits, in terms of the major process parameters. The primary objective of the project is; to optimize the effect of using a pre-forming stage and in continuation of this to determine actual pre-form design rules for the injection forging of tubes. The principle tasks are as follows: 1. To define the optimal pre-forming geometry using finite element models as a design tool; validation will be accomplished through experimental tests in metal. 2. To determine actual pre-form design rules for injection forging of tubes. 3. To give an example of the application of a pre-forming stage for a given component, e.g.: a pulley or a gear. The technical objective of the proposed research is to prove the concept of injection forging and thereby illustrate the production potential of forming tubular components by injection forging.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Between work and welfare: improving return to work strategies for long term absent employees' (RETURN) targeting Fifth Framework.

assistant: **Abstract**

Response to Long Term Absence (LTA) as a result of illness, injury or impairment has the capacity to disable an individual. The process through which this transition occurs is complex and relatively undocumented but involves the work/welfare axis. It is a process that results in economic and social costs for the State, the employer and the individual. Improving the means by which work and welfare based systems manage the challenge of LTA and "disability" must be a key element of any strategy focused on improving quality of life, increasing economic growth and employment, achieving equal opportunities and promoting social inclusion. Return will characterise and describe LTA responses in a number of EU Member States. It will identify enabling and disabling factors within each system. The results will include a package of practical tools to address LTA and return to work and recommendations for strategies to stem the "work to welfare" out flow from employment."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Feasibility Study to Combat Physical Inactivity and Improve Sporting Skills through SCULT Sport Mentors and Coaches Marketplace' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

About 26% of European adults and 80% of adolescents do not engage in sufficient physical activity, leading to over 500 000 premature deaths per year and imposing annual economic costs of over €80 billion. Sport coaching and mentoring fulfills an important social function in educating, motivating and activating citizens to engage in physical activity. However, with current solutions the access for citizens to sport coaches and mentors is chaotic, whereas freelance sport mentors lack the ability to effectively provide and monetize their services. The overall objective of the innovation project is to develop and mainstream SCULTmarket, an interactive platform for “sculting”: facilitating the relationships, activities and service-monetization for sport mentors, coaches and their clients in a mutually benefitting technological, social and educative environment. SCULT Ltd. is the first to the market with a compelling business case to effectively combat physical inactivity in Europe and beyond thanks to its scalable nature and business model based on the logic of on-demand service and sharing economy. The prototype has been validated by an extensive mix of experts and potential users within the SCULT network of about 10 000 people through tests conducted at various sport events and activities. SCULTmarket will attract 250 000 users and 130 000 monthly Mentorship Sessions by the end of 2017, and is foreseen generate an annual turnover of €149 million by 2020. The specific objective of SCULTMARKET project is to  verify the business model from the practical, social, technological and economic point of view. The expected outcome is a detailed business, scaling and brand strategy for commercializing the proposed SCULTmarket application, including an IP strategy. Technical requireme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CroSap: Elucidating the azafrine saponin pathway in crocus' under Horizon Europe.

assistant: **Concept**

Crocus sativus L. is an autumn-flowering perennial geophyte (a monocot belonging to the Iridaceae family) that forms underground corms and is rich in apocarotenoids. The key apocarotenoids including crocin, picrocrocin, and safranal present only in the stigmas, define its unique characteristics. It has recently become apparent that crocus corms are also a source of novel oleanane-type triterpenoid saponins (azafrines). However the biosynthetic route to azafrines in crocus is unknown. By understanding these processes, the Osbourn lab seeks to unlock the azafrine biosynthesis pathways in crocus. In the CroSap project, I will conduct the identification and characterization of candidate azafrine biosynthetic pathway genes through genome and transcriptome mining, phylogenetic and gene expression analysis. Identified genes will then be functionally characterised via combinatorial recombinant expression in the transient plant expression host N. benthamiana and in yeast, and the structures of the resulting compounds determined. These compounds will be purified and screened for potential immunostimulatory activity. I will also provide important new insights into the independent/convergent evolution of pathways for structurally related saponins in distantly related plant species Q. saponaria and S. officinalis (eudicots) and C. sativus (a monocot) and identify new enzyme (sub)families for the bioproduction of these pharmacology important compounds and analogues.


**Keywords:** Synthetic biology, Saponins, General biochemistry and metabolism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Identification and characterisation of new class of PI3K modulators in oncology' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

PI3K signalling is a critical regulator of many cellular functions including cell growth and survival, and is deregulated in cancer and auto-immunity.This proposal is based on the concept to cause cell death by hyperactivating signalling in cancer cells above a tolerable threshold. This idea has been previously proposed for other kinases, but no small-molecule activators were available to formally test the idea. This proposal focuses on activators of the leukocyte-enriched PI3Kd, an isoform of PI3K that is involved in immune regulation and haematological malignancies.The 3 key objectives and their approaches are:1. To discover and characterise small-molecule PI3Kd activators. This will be achieved using a combination of virtual screening and high throughput screening.2. To understand the mechanism of PI3Kd activation. This enables understanding of how these activators function, and provides structural data that can be used for structure-based design and compound improvement. This will be achieved using structural biology (HDX-MS and crystallography), biochemical (lipid kinase) and biophysical (binding) assays.3. To determine the activity of PI3Kd activators in haematopoietic malignancies. In order to use PI3Kd activators in cancer therapy, it is critical to determine the conditions under which hyperactivation of PI3Kd results in cancer cell death. This will be achieved with a panel of B and T-cell lymphoma cell lines using cell viability assays under different conditions.These objectives integrate my expertise in compound screening, molecular modelling and compound design with the world-leading expertise of the Host Lab in PI3K signalling, cancer biology and drug development. This proposal aims to make breakthroughs in understanding PI3K signalling, its exploitation in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Towards Sustainable Tourism Development Models in the Euro Mediterranean region: A case study of Malta and Sardinia'.

assistant: **Innovation**

The proposed research project deals with sustainable tourism development models in the Euro Mediterranean region. According to the European Union policy framework, such as the Lisbon Strategy, addressed to the implementation of sustainability and competitiveness in the European Union countries, the research is aimed to give an original contribution among innovative tourism strategies and practices for enhancing the tourist attractiveness of European destinations. Particularly emphasis is given to the Euro Mediterranean coastal areas such as Malta and Sardinia, in which tourism industry plays a significant role in terms of tourism arrivals, revenue, employment, skills, etc. The research questions are addressed to identify strengths and weaknesses in Malta and Sardinia tourism performances, in order to give recommendations to public and private stakeholders for improving the sustainability and competitiveness of tourism, and to the identification of innovative tourism good practices. The methodological framework is based on a qualitative approach, which adopts qualitative and quantitative methods (mixed methods), such as interviews with key informants and stakeholders, and survey. The proposed research project is expected to renew the knowledge about the topic of sustainable tourism, identify the strength and weaknesses of the tourism system in Malta and Sardinia, provide recommendations for improving sustainable tourism policy and practices in the two chosen areas, share the results among tourism stakeholders, both private and public organisations. Moreover, it is expected to identify innovative tourism good practices in the EU areas related, giving particular attention to socio cultural economic offers, for improving the competitiveness and sustainability of the EU tour
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ecological genomics of vertebrates across environmentally hostile naturally fragmented paleosurfaces' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Long-term population persistence in fragmented landscapes is of interest to evolutionary and conservation biologists. Although the causes of population fragmentation and their effects on genetic structure have been investigated in post-Pleistocene “nutrient-rich” landscapes, pre-Pleistocene nutrient-poor landscapes (paleosurfaces) have seldom been considered by population geneticists. The biotic assemblages of paleosurfaces differ fundamentally in their traits from biotas evolving in post-Pleistocene landscapes. It has been hypothesized that they display more complex population dynamics due to the persistence of old lineages, refugial phenomena, inbreeding, adaptations to resource-limited, highly competitive environments, and high levels of resilience to lower evolutionary potential. In this context, the Pantepui region in the western Guiana Shield is of particular interest as it harbours numerous isolated Precambrian sandstone tabletop mountains (tepuis) reaching up to 3000m and is renowned for its floral and faunal endemism. The “Lost Worlds” of tepui summits face particularly hostile, challenging environmental conditions, and their characteristic vegetation grows on highly acidic, oligotrophic soils. My overarching objective is to determine the extent to which the genetic structure, phenotypic traits, and, ultimately, the evolutionary trajectories of vertebrates are impacted by these environmentally hostile, naturally fragmented, paleosurfaces. I will apply state of the art population genomics and imaging technologies (histology, micro CT scanning) integrated with systems-level ecological data to three tepui summit endemic amphibian and reptile taxa distributed across the summits of four neighbouring isolated tepuis. This will yield new insights into the ecological g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Micro-scanning endoscope with diagnostic and enhanced resolution attributes' (MEDEA).

assistant: **Concept**

Minimally invasive interventions gain a more and more large part of the operative spectrum in surgery, gynecology, urology, neurology, and other medical disciplines. In most of these interventions, the foremost sensory (and often the more exploitable) information is conveyed to the operating team by means of endoscopic vision. Accordingly, the enhancement of endoscopic visualisation systems is an important prerequisite for further progress in this domain. In current situation, this enhancement is directed to future endoscope units, which offer improved resolution, increased miniaturization, higher automation, better image processing, and advanced diagnostic imaging features. These goals correspond to the main objectives of the project. In the above context, the principal work content of the present (MEDEA) project will be the development of a microscanner module settled at the front end of an endoscope for medical or biomedical applications. Secondarily, technical-type applications of this endoscopic device will be also considered. The endoscopic module in question will be based on the principle of confocal scanning techniques combined with multiple laser illumination and electronic control along with image processing and handling of the received output.For specific examinations, of spectroscopic nature, three diode laser beams (of different colours) will be scanned over the target tissue by means of specific micro-optic components and a pivoting silicon-mirror system fabricated in the above module. By means of suitable electronics and software, the detection and measurement of the re-emitted light will be synchronized to the mirrors' movements and will be used for 3_color imaging of the observed objects/tissues after appropriate image and signal processing.The possibil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'DNA Origami for drug delivery'.

assistant: **Objectives**

The main objective of this project is to produce innovative DNA self-assembled nanostructures with the goal of evolving new approaches for drug delivery. The properties of the DNA nanostructures will be tuned by introducing new elements into the nanostructures improving their versatility and structural integrity. This project will aim to:•build and characterise DNA nanostructures using long oligonucleotides of biological production;•add different elements to the nanostructures, such as gold nanoparticles and proteins to the nanostructures to tune the respective intrinsic and structural properties;•develop new strategies to simplify the assessment of the integrity of nanostructures using fluorophores;•apply the newly developed nanostructures to assemble a delivery system for doxorubicin.This project will result in a synergy between the applicant’s particular profile and the high quality of the host institution. The applicant has experience in different sets of scientific areas such as fluorescence and nanotechnology as well as a background in molecular and cell biology. Complementarily, the host institution, the Department of Neuroscience at Karolinska Institutet, and Björn Högberg’s laboratory in particular, will provide the necessary knowledge on DNA nanotechnology. Högberg’s group has recently established itself as one of the leading DNA-nanotechnology labs in Europe with high-impact publications in the field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Understanding the dynamics of cell division' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

This Research Network consists of nine teams that provide an interdisciplinary environment for training researchers in the field of eukaryotic cell division. The teams combine expertise in cell biology, biochemistry, proteomics, biophysics, chemical geneti cs, organic chemistry, and mathematics. The scientific goal of the joint research programme is to understand the dynamics of cell division and to discover inhibitors of mitosis with potential as anti-cancer drugs. The multidisciplinary network aims at over coming the fragmentation of research into the fields of spindle mechanics and cell cycle regulation, at bringing together laboratories working on different model organisms, and facilitating exchange between experimentalists and theoreticians. The network i ntegrates different tasks, for example identifying missing interaction partners of mitotic regulators and motor proteins, developing novel quantitative in vivo fluorescence microscopy assays, performing high-throughput screens of chemical libraries of smal l molecules to identify inhibitors and activators of mitotic proteins, and theoretical modelling of cell division. This Research Network is necessary, because understanding a complex biological process like cell division requires an integrated approach com bining various disciplines and techniques. The need is even more pressing, since diseases related to cell proliferation are a major unsolved problem in European societies and on a world-wide level. In conclusion, training by this Research Network will prep are the early-stage and experienced researchers for tackling complex biological systems like the cell division machine. Quite generally, they will have a qualification to address challenges in modern biology requiring interdisciplinary approches. They will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Personalized diagnostics and treatment of high risk coronary artery disease patients.' (RISKYCAD).

assistant: **Innovation**

Although the accurate diagnosis and prevention of coronary artery disease (CAD), acute myocardial infarction (AMI) and death is a major public health issue, risk stratification for CAD with current diagnostic tools is not properly supporting clinical decision making. RiskyCAD’s overall goal is to identify novel biomarkers for asymptomatic patients in high risk of major coronary events, and develop new diagnostic tools and ‘personalized’ therapeutic strategies for this selected group of patients.Taking advantage of the latest technologies, we will look into new biomarkers for asymptomatic patients in high risk of CAD using some of the finest cohorts (WP1), identify new molecules and develop new diagnostic kits that will be further validated in additional cohorts (WP6). We will generate reprogrammed iPS cell based human models for the study of metabolic aberrations in selected individual vulnerable CAD patients (WP2). We will identify defects, e.g. in liver lipid metabolism, in high risk CAD patients (WP3) and test targeted treatments in traditional and new preclinical animal models to provide proof-of-concept level evidence (WP4, WP5). As our approach is based on well characterized patients and phenotypes, we will generate clinically applicable stratification methods that will allow targeted treatment and patient enrichment for clinical trials (WP1). Unique predictive modelling and link identification platforms including Drug Repositioning will be used to select drugs or drug combinations that will best match the patient’s biomarker profile (WP7).The final (translational) outcomes of this project will be: (i) a set of distinct biomarker test(s) for asymptomatic patients in high risk of CAD that can be ordered both by primary care physicians and specialized cardiologists