RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ecology and biology of HPAIV H5 (Kappa-Flu)' (Kappa-Flu).

assistant: **Innovation**

The global emergence of highly pathogenic avian influenza (HPAI) viruses and the subsequent adaptation to wild birds has resulted in record mortality of wild birds and poultry and is developing into an enzootic threat for wildlife, poultry and human health in Europe. The ongoing evolution of HPAI viruses is expanding their geographical distribution and host range. To deal with this global problem, KAPPA-FLU brings together top experts from Europe, North America and Asia. The overall objective of KAPPA-FLU is the characterization of key viral, host-related and environmental factors that determine the maintenance and the long-distance spread of HPAI viruses in wild birds, with the goal of improving capacities for risk-based surveillance, prevention and control of HPAI in poultry and wildlife, and its potential impact on human health. KAPPA-FLU will follow three research themes. Theme A (Disease ecology) provides a deep understanding of the population dynamics of HPAI viruses in migratory waterbirds and spill-over hosts, both resident wildlife and poultry, through risk-based surveillance strategies, and accounting for the impact of climate change. Theme B (Virology) studies the evolution of HPAI viruses in wild birds and poultry and the resulting increasing risk to humans and other mammals. Based on the above results, theme C (Agro-ecosystem risk) identifies and models prevention and control strategies (including vaccination) using machine learning algorithms. Actors from different sectors of society will, through the Multi-Actor Panel, play key roles in translating results into policy and practice. In this way, KAPPA-FLU will make stepwise advances in knowledge of the population dynamics and evolution of HPAI, and thus contribute to a sustainable poultry production system
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DC-based immunotherapy to treat Malignant Mesothelioma', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Asbestos is one of the major occupational carcinogens. The European Union has an extensive history of protecting workers and consumers against asbestos and even adopted a resolution 2012/2065(INI) ‘on asbestos related occupational health threats and prospects for abolishing all existing asbestos’ last year. Although asbestos is banned, it is still massively present in the built environment. Millions of workers & consumers in the EU were, and still are, for many years exposed to asbestos fibres, despite all measures.Inhalation of even very low quantities of asbestos fibres tremendously increases the risk of developing Malignant Mesothelioma (MM). The IARC reported 8.100 MM deaths in 2010 in the EU. Despite all EU actions, MM incidence is still increasing. MM is a highly fatal disease with a poor median survival time from first signs of illness to death around 12 months despite aggressive treatments. To date there is no curative therapy for MM. MM is considered as an extremely therapy-resistant disease. Chemotherapy consisting of a combination of pemetrexed and cisplatin is considered standard of care with a median survival increase of 3 months (9-12 months).The department of pulmonary diseases of the Erasmus MC, Rotterdam, The Netherlands, in collaboration with international partners, have developed a promising personalised immunotherapy for MM with very limited adverse effects. The first clinical results show a considerably prolonged average survival with limited adverse events (24 months, twice as long).The EMA and the FDA granted this therapy Orphan Designation: autologous dendritic cells pulsed with allogeneic tumour cell lysate for the treatment of malignant mesothelioma (EU: 16 January 2014 - EU/3/13/1229; FDA – US: 06 May 2014).The objective for the project is to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Fluctuations in Atomtronic Circuits'.

assistant: **Innovation**

Ultracold quantum gases provide a unique highly-controllable platform to test fundamental aspects of quantum mechanics and to engineer novel quantum technologies and sensing devices. Recently, an emerging subfield called “atomtronics” is attracting increasing interest. Atomtronics aims to study neutral atomic circuits in optical and magnetic traps, in a manner analogous, but complementary, to electronic circuits. This proposal focusses on two key aspects in such systems, namely on modelling the dynamics in ring-trap geometries – which benefit from the topological protection of (neutral) atomic currents – and characterizing the dynamical emergence and transfer of coherence in analogue neutral-atomic transistors. The novel feature of this project is the inclusion of experimentally-relevant fluctuations via appropriate state-of-the-art modelling schemes (namely the stochastic Gross-Pitaevskii and the Zaremba-Nikuni-Griffin model) which fully include coupling of coherent and incoherent modes and associated fluctuations, made possible through high-performance computing simulations. The specific end-goal is to provide an in-depth characterisation of the dynamics of coherence in such circuits, thus both addressing open questions in the literature and identifying from the theoretical perspective the optimal specifications and parameter regimes which experimentalists could use to create an advanced atomic sensing device (atomic analogue of the superconducting quantum-interference device) and an atomic ring-based transistor. The proposed research has strong connections with existing experimental implementations, including the existing/planned setups at FORTH (Crete) [von Klitzing's group] and LKB (Paris) [Beugnon/Dalibard group], where the applicant will perform targeted secondme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Integrative, AI-aided Inference of Protein Structure and Dynamics'.

assistant: **Objectives**

The life sciences community is living in exciting times. During the past year, Artificial Intelligence (AI), and in particular AlphaFold2, has contributed to advancing our understanding of protein behaviour by enabling structure prediction with accuracy comparable to many experimental techniques at a fraction of their time and costs. However, structures are only a piece of the puzzle. To understand the mechanisms underlying biological functions, we need to characterize the conformational landscape of proteins, the population of relevant states, and their pathways of interconversion. Furthermore, we need to determine the effect of the environment in modulating structures, populations, and pathways, as biological systems perform their functions in the complexity of cells rather than in the isolation of test tubes. None of these objectives can be achieved by AI structure-prediction methods alone. In this proposal we will leverage the PIs expertise in the field of integrative computational-experimental techniques to develop, apply, and disseminate bAIes, a modelling approach that will enable attaining these goals. bAIes will make synergistic use of AI structural models, experimental data, and molecular simulations driven by accurate physico-chemical models to characterize protein structure and dynamics. We will demonstrate how bAIes can solve biological problems that exceed the capabilities of AI approaches,  such as the characterization of protein disordered regions and the determination of structure and dynamics in situ, with a particular focus on the SARS-CoV-2 spike protein. The outcome of this proposal will be a versatile, accurate and efficient method that will push the boundaries of what can be achieved with AI structure-prediction methods. bAIes will be implemented
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multi-scale protein and phospholipid membrane interactions', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Transmembrane proteins interact which each other directly or mediated via their influence on the lipid membrane structure and fluctuations. The interactions govern the dynamics of integral protein insertion, (re-) folding and assembly in functional oligomeric structures such as the tetrameric potassium channel KcsA.On the other hand, antimicrobial peptides as defensins and magainins aggregate supposedly either in the lipid head group region or in a transmembrane fashion leading to permeation and rupture of bacterial membranes. The mechanisms of these processes are very difficult to study experimentally.The objective of our research proposal is to model protein-membrane interactions by multi-scale molecular dynamics simulation. Using a quantitative coarse g rain description, we can access the spatial and temporal scales of these processes, which are too large for direct simulation with atomistic molecular dynamics.However, using a special interface between our coarse grain representation and the all atom rep resentation of the system, we can connect the mesoscale phenomena to the underlying atomistic details.Using special techniques as path sampling and the novel metadynamics method, we will map out the free energy landscape of interacting transmembrane prote ins in terms of generic hydrophobic, hydrophilic and electrostatic interactions, specific protein residue interactions, and interactions induced by lipid ordering and friction.If successful, the results are expected to gain insight in how peptides and proteins insert and interact in biomembranes which is of interest to a wide variety of applications, in particular for drug design and for the development of biomimetic antimicrobials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of Inorganic Membrane Reactors for Selective Oxidation of Hydrocarbons to Oxygenates in particular n-Butane to Maleic Anhydride' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives and content Oxidation of hydrocarbons to oxygenates is normally limited by low selectivity due to carbon dioxide formation and by conversion, so the resulting yield is often below 80-90%. The present research programme focuses on the selective oxidation of n-butane to maleic anhydride where the yield is even below 60%. Maleic anhydride is an important intermediary in the manufacture of unsaturated polyester resins and the production increases by several per cent annually. It is the aim of this research programme to develop a reactor based on ceramic membranes where the reaction between butane and air/oxygen takes place either on a catalyst within the membrane tube or at a catalytic surface created within the membrane wall. It is expected that the selectivities achievable in such reactors will be above 90%. The catalyst will be optimized for the membrane reactor. Methods for deposition of catalyst in the membrane reactor wall will be developed and the catalysts and membranes will be thoroughly characterized before and after membrane reactor studies. A package for the design of a pilot or demonstration membrane reactor will be the end product of the project. It is widely recognized that an industrial breakthrough in the use of high temperature membrane reactors mainly depends on whether or not highly perm-selective and stable membranes will be developed. Overall, this should lead to a substantially improved process with lower investment costs and lower consumption figures. Besides the increased selectivity, the latter will also involve a substantially reduced emission of carbon dioxide. The expected development should be transferable to other selective oxidation reactions such as the production of phthalic anhydride and acrylonitrile.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PErvasive COmponent Systems' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Plummeting hardware costs are leading to an explosion of interest in new applications of embedded systems. Component-based software development (CBSD) would be ideally suited to the development of families of flexible, adaptable embedded systems applications, but unfortunately the state-of-the-art does not support the special requirements of embedded applications, particularly meeting the sever resource-constraints and the expression and validation of non-functional constraints. PECOS seeks to enable CBSD for embedded systems by defining a meta model as well as a repository for components that reflects non-functional requirements, integrating these additional features in a graphical composition environment, and developing an ultra light component environment that allows to run the composed application on the embedded system.Objectives:The PECOS project aims to enable component-based software development for embedded systems. While focusing on architectural issues it touches upon the whole software development life cycle and addresses the major technological deficiencies of state-of-the-art component technology with respect to embedded systems by developing:(i) a Component Model for embedded system components addressing behaviour specification and non-functional properties and constraints;(ii) a Component Repository utilising this model, supporting a composition environment and interfacing to a component specification environment;(iii) an interactive Composition Environment for composing embedded applications from components, validating functional (e.g., interfaces) and non-functional compositional constraints (e.g., power-consumption, code size), generating the application executable for the embedded device and monitoring their execution,(iv) an Ultra-light Component En
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Immunological engineering for generation of human therapeutic antibodies', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives:The objectives of this proposal are partially based on our previous results from the EC Biotechnology (1992-1994) project In vitro immunization of human B lymphocytes" where we have already shown the potential of in-vitro immunization to generate affinity-maturated and isotype-switched human monoclonal antibodies which potentially could be applied in a therapeutic context. Based on this progress, the objectives have been refocused to be more directly applied and complies with the policies of the 4th Framework EC Biotechnology programme (1994-98).The project involves two conceptually different but complementary approaches to obtain develop human high affinity antibodies of therapeutic interest. These approaches use cell biology to mimick the germinal center environment and molecular biology approaches based on antibody libraries and phage display. Our objectives include the following elements: (1) Optimised in-vitro immunization protocols generating specific immunization and somatic mutation of human B cells. (2) Improved methods for the rescue of V regions from B cells. (3) Novel design of V-gene repertoires. (4) Analysis and characterization of anti-tumour antibodies with respect to specificity and effector functions. (5) Improvement of antibodies by in-vitro evolution of affinity and specificity. (6) Engineering and production of molecules (antibodies and fusion proteins) for therapy. Outline of proposal content: Mimicking the GC micro-environment. The production of high affinity human antibodies requires that B cells first undergo somatic hypermutation of Ig V-region genes and that the high-affinity mutations are selected and expanded. In-vivo, these somatic mutations take place within the germinal centers (GC) of B cell follicles in secondary lymphoid org
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Space & Earth Reliable greENhouse desIgn meThodologY' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

With a return of human exploration missions to the Moon in the mid-2020s and the preparation of more distant and longer-duration missions to Mars and further into the solar system, large-scale sustainable and reliable food production systems will need to be developed. Until now, only small-scale plant growth systems have been operated in space and they still pose numerous challenges. To be sustainable, greenhouse modules (GHM) for space need to use few resources, present low risk, be robust, reliable, and resilient. Therefore, this project aims at developing a methodology allowing space and terrestrial GHM design based on given constraints, using modelling, simulations, and optimization, with a process engineering and system engineering approach. The first objective is the analysis of constraints and objectives. This will be achieved after review and definition of environmental parameters constraints, criteria pertaining to GHM stability and reliability, and subsystem modelling, through extended literature review. The second objective is the systematic generation of competing designs using simulation tools based on constraints defined in objective 1. The interpretation of these results is the second part of this objective and is achieved with comparing different GHM designs, using criteria linked to used resources (energy, water, crew time), resources production (food, oxygen, water), as well as reliability, sustainability and risk. The third objective is the decision on a systematic approach to choose the best solution and provide recommendations for plant growth systems design in different gravity scenario. This project will fill the gap for the development of space and terrestrial food production systems and thus allow human exploration of Mars. It will allow Dr. Pou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cracking the Anterior Cingulate Code: Toward a Unified Theory of ACC Function' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Anterior cingulate cortex is one of the largest riddles in cognitive neuroscience and presents a major challenge to mental health research. ACC dysfunction contributes to a wide spectrum of psychiatric and neurological disorders but no one knows what it actually does. Although more than a thousand papers are published about it each year, attempts to identify its function have been confounded by the fact that a multiplicity of tasks and events activate ACC, as if it were involved in everything.Recently, I proposed a theory that reconciles many of the complexities surrounding ACC. This holds that ACC selects and motivates high-level, temporally extended behaviors according to principles of hierarchical reinforcement learning. For example, on this view ACC would be responsible for initiating and sustaining a run up a steep mountain. I have instantiated this theory in two computational models that make explicit the theory's assumptions, while yielding testable predictions. In this project I will integrate the two computational models into a unified, biologically-realistic model of ACC function, which will be evaluated using mathematical techniques from non-linear dynamical systems analysis. I will then systematically test the unified model in a series of experiments involving functional magnetic resonance imaging, electroencephalography and psychopharmacology, in both healthy human subjects and patients.The establishment of a complete, formal account of ACC will fill an important gap in the cognitive neuroscience of cognitive control and decision making, strongly impact clinical practice, and be important for artificial intelligence and robotics research, which draws inspiration from brain-based mechanisms for cognitive control. The computational modelling work will also li