RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'GAIA COFUND', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

GAIA COFUND will bring climate research-based knowledge – climate mitigation and adaption – into help solving real world problems and challenges. By connecting science with society in a practical manner, targeting research through a transdisciplinary approach involving industrial partners, we will pave the way for a climate academic career paths into industry. An eligible applicant will carry out a research project that will enable them to become future leaders, either in academia or in industry. The main objective of GAIA is to fund 15 two-year postdoc fellowships to excellent and promising young scientists from all over the World, with a strong emphasis on secondment in industry. GAIA will establish a postdoctoral training program that combine excellent and responsible research, open science, innovation, and climate change challenges, thus laying the foundation for the next generation of researchers rooted in climate science with a global outlook and an end-user perspective. With 24 partners, GAIA will offer access to an extensive academic and non-academic network Europe wide. The program will enable University of Southern Denmark (SDU) to elevate its strong position in climate research with world leading research groups, broaden the scope and sustainability of emerging research areas, and facilitate a vibrant and even more attractive research environment, combined with an outreach to local and international industrial partners looking for science-based solutions. SDU has 27,000 students and 3,800 employees with 24 departments within the faculties of the humanities, social sciences, natural sciences, health sciences, and engineering. SDU is ranked among the top universities in Denmark. GAIA will be part of the SDU Climate Cluster (SCC) established in 2022 with a budge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mobile Cross-Border Government Services for Europe' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The “Mobile Cross-Border Government Services for Europe” (mGov4EU) project will lift cross-border services supported by the Single Digital Gateway Regulation (SDGR) and by the eIDAS Regulation to new levels by enabling them for a mobile-device use we nowadays naturally expect. This shall come with unprecedented user journeys by making extensive use of automatic attribute provision and SDGR’s once-only principle, complemented by mobile identification so that the so-far cumbersome filling of complex forms gets replaced by user-controlled and user-consented releasing of authoritative data. By taking advantage of security features of modern smartphones like hardware-backed secure elements together with integrated convenience elements like biometric sensors, mGov4EU will meet both the security needs and data-protection expectations one has into public services and the usability challenges that arise when accessing complex services using constrained mobile devices. mGov4EU will, therefore, research, design, implement, and evaluate an open ecosystem for secure mobile government services to be used across Europe and beyond. This is accomplished by combining and enhancing the existing eIDAS Layer and SDGR Layer with modules for mobile devices that are generic enough so that they can be re-used in the emerging and thus still heterogeneous European mobile-government landscape. Thus, mGov4EU will provide a trustworthy federation of collaborative platforms, which facilitates the co-delivery, reuse, and trustworthy provision of accessible and easy-to-use public services. mGov4EU will implement the once-only, digital-by-default and mobile-first principles in a user centric and user friendly manner in order to support and complement the practical implementation of the eIDAS and the Sin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Decision-Making from Visual Cortex to Midbrain', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Every day, we make a myriad of movements executing decisions that are based on visual information. We want to understand how these decisions are formed in the brain, and how information is processed along the hierarchy of visual areas and in superior colliculus (SC), a motor structure of the midbrain. In primates, cortical visual areas progressively encode more complex stimulus features. But signals that reflect the percept in addition to the stimulus are already present at early stages of visual processing. Activity in SC controls eye and head movements, but might also have more abstract roles in decision-making reflecting task difficulty and performance.The neural circuit underlying these decision processes is not yet understood. Genetics tools to tag, monitor and manipulate active cells were recently developed for mice and can help unravel these circuits. This requires, however, that the role of various brain areas of the mouse in decision-making is solidly understood. To that end, we will train mice to perform visual decision tasks of different complexity and record the activity of large neuronal populations in cortical visual areas and SC using a genetically encoded calcium indicator. We will quantify in each area how strongly single neurons and the neuronal population are driven by visual stimuli in contrast to the mouse’s decisions and performance. We will compare the time courses of responses between areas, elucidating how different areas interact with each other. To probe the involvement of different visual areas in tasks of varying complexity, we will quantify the mouse’s performance while inactivating those areas using optogenetics.This project will track the representation of visual decisions across brain areas and across time, giving insights into the imple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Microglia Control of Physiological Brain States' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The brain controls all body functions. At the base of this 'catholic' role are the neurons, cells that generate electrical signals, communicate via synapses and form circuits that execute computing tasks and control behaviour. The electrical signalling pattern of neurons is the information code of the brain and the synapse connectivity determines circuit function. This is, in brief, what most textbooks emphasise, but such a neuron-centred brain view is precariously short-sighted. Apart from neurons, the brain contains three glia cell types (from Greek 'γλία' for 'glue'): astrocytes, oligodendrocytes, and microglia. But far from being mere 'glue', astrocytes and oligodendrocytes have multiple critical functions in the brain, accordingly affect many brain processes - even genuine computing tasks - and have therefore become a major focus of modern neuroscience. Microglia are the 'odd one out'. They are brain-resident immune cells, act as defence against pathological insults and have a housekeeping function as phagocytes. Aside from these functions, microglia seem to play an as yet unrecognized role by engaging in reciprocal signalling with neurons. It is this Microglia Control of Physiological Brain States we will study in MICRO-COPS, based on the hypothesis that microglia purposively control neuronal function. We will combine mouse genetics with cutting-edge gene expression analysis and cell biological, electrophysiological, and imaging technologies to define the reciprocal microglia-neuron signalling pathways, the signalling molecules involved, the biological consequences for microglia and neurons, and the role of the corresponding signalling processes in synapse physiology, neuronal integration, circuit dynamics, and behaviour. We expect that the mechanistic description
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'New cost effective and minimally invasive endoscopic device able to investigate the colonic mucosa, ensuring a high level of navigation accuracy and enhanced diagnostic capabilities""'.

assistant: **Concept**

Colon diseases are one of the most interesting chapters of public health. Every year millions of people around the world are undergoing colonoscopy or other colon investigations. Although optical Colonoscopy is currently considered the standard diagnostic methodology for the evaluation of intestinal colic disease, it is however an invasive examination with important limitations in terms of risks and patient acceptability.  In this framework, the SUPCAM project aims at developing a new cost effective and minimally invasive biomedical device able to investigate the colonic mucosa, ensuring a high level of navigation accuracy, enhanced diagnostic capabilities as well as a substantial reduction of discomforts typical of current diagnostic practices. The SUPCAM concept is based on the development of a endoscopic capsule whose structure and innovative design allow to safely and accurately guide it along the colonic lumen from the outside, through an electromagnet, completely wireless. The main goal of SUPCAM is to provide a new mechanical configuration of the endoscopic capsule able to allow the medical examination through an external system with an elementary structure, economic, with small footprint and usable at outpatient level, but ensuring an accurate vision of the colonic mucosa. The development of this innovative video capsule with magnetic control will have significant advantages for the patients, reducing clinical risk, improving tolerance and acceptability and considerably enlarging the diffusion of colo-rectal cancer screening on the territory, with consequent benefits for the whole social healthcare system. SUPCAM project will help the 34,500 SMEs active in EU in the biomedical sector to enter in endoscopic market with an innovative product, maximising their econ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'All-acoustic Bubble Microrheology for rapid screening of formulations'.

assistant: **Objectives**

ABuMic aims to address a critical challenge of our society: the transition of formulated products to a safer and more sustainable industry. There is increasing pressure on the industry, both from the public opinion and regulatory bodies, for healthier food products and more environmentally friendly paints and coatings. As a result, in the coming years many formulated products will need to be re-formulated. This will come at a huge cost for the industry, because by and large, product development is still done by trial-and-error. This means that the formulated products industry needs more than ever the capability to predict formulation performance for rapid screening of new products. The current challenge is that processing flows and end-use produce flow conditions that are not accessible with existing methods for materials characterization. With the ABuMic device, a formulation scientist will be able to design a new product more quickly and efficiently, thereby lowering the cost of new product development, and supporting the transition to healthier and more sustainable products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Training for Organoids modelling Physiology and Pathology in the human gastrointestinal tract' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In the aging society, disease burden, such as degenerative diseases and cancer are rising while drug development successes are limited, due to high drug failure rates in the transition from animal experimentation to human patients. This demands re-thinking of the currently used models. Advances in stem cell biology and microfluidics have created new human organ models. These models are neither fully understood, nor fully mimicking the complexity of the tissue. With this new ability to build human stem cell-based models, we have a responsibility to drive these models to implementation – aiming to replace animal experimentation and provide next generation patient avatars for precision medicine. TOP-GUT combines cutting-edge basic and translational science with an outstanding program of education to unleash the full potential of new human organ models, specifically patient-derived organoids and organ-on-chip devices. TOP-GUT will focus on the gastrointestinal (GI) tract, which is the bodies second largest interface with the environment. It is medically highly relevant not only as a major site of cancer development, as target of infectious agents, and as site of inflammatory diseases, but also as one of the major organs for drug uptake and relevance in toxicology. TOP-GUT aims to significantly contribute to our understanding of the current GI models, establish new tools and protocols for more complex GI models, and advance the use of GI models for personalised medicine. In addition, TOP-GUT will address ethical and legal issues to foster acceptance and implementation of the GI models. TOP-GUT will build a solid European network to cooperate, standardize and push GI models into applications, bringing together academia and industry. Together, TOP-GUT educates the next generat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Carbonate Biomineralization in the Marine Environment: Paleo-climate proxies and the origin of vital effects' (BIOCARB) targeting Seventh Framework.

assistant: **Abstract**

This interdisciplinary proposal has the objective to greatly enhance our understanding of fundamental biomineralization processes involved in the formation of calcium carbonates by marine organisms, such as corals, foraminifera and bivalves, in order to better understand vital effects. This is essential to the application of these carbonates as proxies for global (paleo-) environmental change. The core of the proposal is an experimental capability that I have pioneered during 2008: Dynamic stable isotopic labeling during formation of carbonate skeletons, tests, and shells, combined with NanoSIMS imaging. The NanoSIMS ion microprobe is a state-of-the-art analytical technology that allows precise elemental and isotopic imaging with a spatial resolution of ~100 nanometers. NanoSIMS imaging of the isotopic label(s) in the resulting biocarbonates and in associated cell-structures will be used to uncover cellular-level transport processes, timescales of formation of different biocarbonate components, as well as trace-elemental and isotopic fractionations. This will uncover the origin of vital effects. With this proposal, I establish a new scientific frontier and guarantee European leadership. The technical and scientific developments resulting from this work are broadly applicable and will radically change scientific ideas about marine carbonate biomineralization and compositional vital effects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Intestinal Lipoidal Nanostructures - A Lipid Bridge to Increased Drug Delivery', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

My research program explores molecular interplay between drug, dosage form and the complex environment of the gastrointestinal tract (GIT). Drug molecules currently being discovered to cure e.g. CNS diseases, cancer and the metabolic syndrome show poor water solubility and 70-90% of recently discovered drugs have too poor solubility to allow absorption from the GIT. For such compounds the dosage form can significantly improve the absorption. My long-term goal is to establish a computational platform that predicts, from molecular structures and computational tools, the development potential of drug molecules to well-functioning orally administered medicines. A major gap to understand drug performance in the intestine is the poor knowledge of the dynamics of solubilizing lipoidal nanostructures (micelles, vesicles, oil droplets) present in the fluid. This project explores restructuring of these lipid colloids in response to intake of food or dosage forms, enzymatic digestion, absorption and transit along the GIT. Novel experimental tools are developed to reveal the impact of these nanostructures on drug solubilization, supersaturation and likelihood of precipitation in vivo, all being important for drug absorption. The experimental results are fed into in silico models taking use of Molecular Dynamics simulations to develop a computational platform predicting drug performance in the dynamic intestinal milieu. The novel tools designed herein will allow dosage forms that improve performance and increase drug absorption after oral administration to, for the first time, be designed by computational means. The results of this project, in particular the novel in silico tools exploring rearrangement of lipoidal nanostructures, are highly important to related areas such as GIT di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'SAFECHILD: Innovative Safety System for Children Transported in Vehicles'.

assistant: **Objectives**

The overall objective of the SAFECHILD project is to significantly improve children’s safety when they are transported onprivate vehicles. SAFECHILD will launch the production and sale of a new SAFECHILD Child Restraint System (CRS) thatoffers better protection than any other device available in the market. This new safety system meets the applicable UN/ECERegulations 129 and goes further by setting the basis for a new standard in protecting the youngest passengers.The sequential ambition of the company leading this project (IDAP Technology) is to create a new brand of CRS, toapproach car Original Equipment Manufacturers (OEMs) in order they include the new CRS solution in their portfolios ofsafety systems and, finally, to become main manufacturer of CRS solutions for those third parties. Summarizing, the currentSMEs Instrument project will allow to perform appropriated market research and define in detail SAFECHILD Business Plan,to create strong presence on the Internet and to enlarge selling opportunities from the on-line mass market to, for instance,the car OEMs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'OnboARd TreatMent of Ballast water (technologies, development and applications) and application of low-sulphur marine fuel' under Fifth Framework.

assistant: **Concept**

The objectives of the proposed research are: (1) to investigate methodologies for preventing the introduction of non indigenous species through ships' ballast water; (2) to develop design tools and treatment equipment to be used in the further development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Fighting cancer with next generation oncolytic immunotherapy in ovarian, head & neck, and lung cancers (Immune Checkpoint Response Enabling Adenovirus Technology )'.

assistant: **Innovation**

TILT Biotherapeutics is a clinical-stage biotechnology company developing novel gene therapies for cancer. TILTs lead asset, TILT-123, is an oncolytic adenovirus armed with two human cytokines: TNF alpha and IL-2. TILT-123 is now in several Phase 1 clinical trials in Europe, the U.S. and China. The asset has been tailored to immunologically heat up cold tumors. Multiple antitumor mechanisms are activated: direct immunogenic killing of cancer cells while sparing healthy cells, release of tumor epitopes, production of cytokines locally at the tumor, and stimulation of patients own immune system to attack cancer. This approach provides the tumor with presence of immune cells: a prerequisite for immune checkpoint inhibitors (ICIs) to work and benefit patients. The project objective is to provide a curative treatment option to patients with refractory cancer, such as the ovarian, head and neck, or lung cancer and secure a global pharmaceutical customer to take TILT-123 to the market.


**Keywords:** oncolytic virus,immune checkpoint inhibitor,ovarian cancer,lung cancer,head and neck cancer,cancer immunotherapy