RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Pre-clinical studies towards an affordable, safe and efficacious two-component paediatric malaria vaccine' to be submitted under Sixth Framework.

assistant: **Abstract**

Malaria is one of the major public health challenges in the world, causing more than one million deaths each year. The disease affects primarily children of the developing world, and it is understood to be both a disease of poverty and a cause of poverty. The available measures, such as personal protection or drugs, have proven insufficient to control the disease. A safe, affordable and efficacious paediatric malaria vaccine, which fits in the existing WHO Expanded Program on Immunization, would solve tremendous suffering to human kind.Taking up this challenge, the PRIBOMAL consortium proposes to generate and test in pre-clinical models the safety and efficacy of an innovative malaria vaccine. The vaccine consists of a prime, to be administered at birth, of a proprietary novel recombinant BCG vector carrying three antigens derived from the Plasmodium falciparum parasite, the cause of malaria. The priming vaccine is followed at week 14 after birth by a booster vaccination using proprietary, industrially developed, recombinant adenoviral vector carrying the identical Plasmodium falciparum antigens as the rBCG-based malaria vaccine. The antigens inserted into the vaccine carriers are circumsporozoite protein, liver stage antigen-1 and sporozoite threonine and asparagine rich protein, which all three are proven highly immunogenic in humans.Generation of these novel vaccine candidates as well as testing in established and novel pre-clinical models to determine potency and safety requires a combined European effort to bring together the required expertise on basic parasite biology, malaria epidemiology, disease onset and progression, recombinant vector technology, fundamental immunology, advanced animal models, and sophisticated proteomics. The international PRIBOMAL consorti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Mechanisms of tissue size regulation in spinal cord development'.

assistant: **Innovation**

How the organs of a developing organism achieve their correct size and shape is a fundamental unresolved question in biology. Mammalian embryos possess a remarkable ability to regulate (restore) the correct size of their tissues and organs upon perturbations during early development, yet how this is achieved is unknown. Addressing this question has so far been challenging because it requires a multiscale approach that integrates precise measurements with theoretical frameworks. We are now in an excellent position to unravel the mechanisms by which the mouse spinal cord regulates its size and shape during development by building on our experience with quantitative studies in this system. We previously obtained quantitative spatiotemporal data of growth, pattern and morphogen signalling dynamics in the spinal cord. We showed that there is a critical period during which morphogen signaling is interpreted to specify cell fates, uncovered a mechanism that allows precise pattern formation, and identified a link between the growth rate and tissue anisotropy. Our expertise now enables us to address the following new questions: 1) how is size regulation in the spinal cord achieved at the tissue and cellular level; 2) what is the molecular mechanism of size regulation, in particular the role of morphogen signaling; 3) how is the regulation of spinal cord size linked to the regulation of its shape. To address these questions, we will combine precisely controlled ex vivo assays in organoids and whole embryo culture, and in vivo advanced mouse genetics and mosaic analysis. We will obtain highly resolved dynamic data and interpret it in the context of rigorous theoretical frameworks. The project will advance our understanding of the fundamental mechanisms of tissue size control and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Cultural Expertise in Europe: What is it useful for?'.

assistant: **Innovation**

Respect for diversity has been at the forefront of political accession to the European Union since 1993 and socio-legal scholarship has developed articulated reflections on the accommodation of ethnic and religious minorities in Europe. Country-experts have been instructed with increasing frequency in judicial and pre-judicial proceedings involving members of diasporic communities. In some common law countries the role of the expert witness has expanded to systematically assist the judge when litigants or defendants belong to minorities; in most civil law countries, similar roles are played by translators and cultural mediators, including notaries and lawyers. Cultural expertise is sometimes used in order to avoid excessive judicialisation. Notwithstanding, disbelief is developing around cultural expertise; and, excalations of violence and counter-violence signal that European majority and the so-called minorities are drifting apart. Hence our question: Cultural Expertise in Europe: What is it useful for? A comprehensive assessment of cultural expertise was entrenched by its narrow technical definition. This project develops around a new integrated concept of cultural expertise to empirically investigate its use and impact in fourteen European countries. In-context data will be collected through ethnographic fieldwork conducted by a modular team allowing real time analysis and immediate use of results by the stakeholders. The objectives will be to: 1) map the terms, condition, and costs of cultural expertise in private and public law; 2) create a toolkit for measuring the impact of cultural expertise; 3) establish an open access searchable data base for the consultation of cases and solution including cultural expertise; 4) design a teaching and learning module using th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Optimizing stratification for trial design in Alzheimer’s disease' to be submitted under Horizon Europe.

assistant: **Abstract**

Alzheimer’s disease (AD) heterogeneity is associated with distinct risk factors, clinical manifestations, rates of cognitive decline, and comorbidities. However, this population variance is not properly incorporated in clinical trial design, directly hampering successful development of treatments. As the field is shifting towards (early) secondary or event primary intervention, the overall objective of the current project is to optimize clinical trial design of an early AD population, by providing data-driven guidelines for sample stratification and outcome measures. To this end, I will assess neurobiological heterogeneity in ~2000 cognitively unimpaired (CU) and ~900 mildly impaired (MCI) subjects enrolled in the BioFINDER study from Lund University (host institution). Using their unique data-set, I aim to identify subtypes of amyloid-β (Aβ)-vascular interplay, the two most common co-occurring and interacting pathologies in the aging brain. Next, the role of neuronal function, microglial activation, and novel targets through proteomics analyses based on CSF/plasma biomarkers on disease progression within these subgroups will be determined. Finally, resulting tau-PET accumulation patterns and cognitive decline across domains across will be assessed. A main innovative aspect and strength of this project is the utilization of regional information available from the imaging modalities, an aspect of analyses which I have specialized in. In turn, the expertise of the host institution regarding fluid biomarkers and tau-PET imaging is paramount to support this multi-modal project. Finally, our respective experience with longitudinal study design will support a critical aspect of the project, which is lacking even in the most comprehensive studies to date. Unravelling heterogen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Controlling Electric Signals with Insulating Antiferromagnets and Insulating Ferromagnets'.

assistant: **Innovation**

The proposal aims to facilitate a revolution of information and communication technologies by controlling electric signals with antiferromagnetic insulators and ferromagnetic insulators. We recently discovered that antiferromagnets can be active components in spintronics devices despite their lack of a macroscopic magnetic moment, and even when they are insulating.Conventional electronics- and spintronics-based logic and memory devices, interconnects, and microwave oscillators are based on (spin-polarized) charge transport, which inherently dissipates power due to ohmic losses. The research proposed seeks to determine the extents to which “Insulatronics” has the potential to control the electric and thermal signal generation, transmission, and detection in more power-efficient ways.Insulatronics is profoundly different because there are no moving charges involved so the power reduction is significant. We hope to establish the extents to which spin-waves and coherent magnons in antiferromagnetic insulators and ferromagnetic insulators can be strongly coupled to electric and thermal currents in adjacent conductors and utilize this coupling to control electric signals. The coupling will be facilitated by spin-transfer torques and spin-pumping – a technique we pioneered – as well as spin-orbit torques and its reciprocal process of charge-pumping.The core of this project focuses on the theoretical and fundamental challenges facing Insulatronics. Beyond the duration of the project, if we are successful, the use of spin signals in insulators with extremely low power dissipation may enable superior low-power technologies such as oscillators, logic devices, interconnects, non-volatile random access memories, and perhaps even quantum information processing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A Renewable Approach for Industrial Water Desalination by using Hybrid Photovolt'.

assistant: **Objectives**

According to the World Water Council (WWC), by the year 2050, our energy needs will have increased by approximately 60%. Understanding the interactions between water and energy is important to further develop our water security. It is estimated that 15% of world-wide water use is for industrial purpose and industrial water pollution is a major source of damage to ecosystems and human health throughout the world. Sustainable water management is recognised as a priority for several industry sectors and is vital to reduce water and energy use. The development of evaporation technologies together with the use of renewable energies becomes a promising solution to get rid of the fossil dependence and met the European Union combined targets for water and energy sustainably, but additional effort is required from both industries in order to market uptake low cost and energy efficient water treatment solutions in the mid-term. On the other side, the global water and wastewater (W&WW) generation market revenue is estimated in 3.5 Billion Euros by 2017 with a CAGR of 5.6%. The previous scenario have encouraged Hydro Italia SRL, an environmental oriented company with 20 years of experience in the water field, to develop the SolardeSaLt solution. SolardeSalt is a medium size water evaporation system which employs evaporation technology coupled with hybrid PV-Thermal (PVT) panels to produce desalinated water. This technology will significantly improve the present techno-economic efficiency (industrial evaporators efficiency is around 90-95%) of high capacity solar evaporation systems and therefore, reduce the cost of water production from 35 to 40% .SolardeSalt will be focused on the W&WW treatment solutions field, which was represented by a market share of 2 Billion EUR in 2012 . Fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dance-induced Neural Synchrony for Embodied Connection' in the context of a Horizon Europe call.

assistant: **Objectives**

Chronic pain is a major public health challenge in the EU. Fibromyalgia (FM), a common chronic pain condition, disrupts both bodily self-consciousness and its connection to that of others (the social bodily self). No cure and complex symptomatology lead to invisible disability, alienation and social difficulties, creating an urgent need for new theoretical approaches and treatments. One of the most effective interventions is dance, although there are no specific dance training protocols for FM, and the mechanisms in dance responsible for its health benefits remain unknown. In typical adults, moving in synchrony with others triggers interpersonal neural synchrony (INS) (of movement, physiological function and brain activity), which increases bonding and reduces pain. It is unknown whether people with chronic pain experience the same INS and how this may affect their bodily self and social connectedness.Therefore, our aims are: 1) to co-design and validate a dance protocol for investigating INS in FM, and 2) to investigate the effects of social (vs individual) dance on the social bodily self in FM to reveal the role of INS in these effects. Our project is based on a participatory design and a robust experimental plan, including a randomised controlled trial. We will use functional near-infrared spectroscopy hyperscanning, physiological recording, and precise body tracking to quantify INS during dance in people with pain and pain-free controls. The key impact of DaNSEC will be new high quality knowledge, made possible by the complementary expertise of two world-class advisors in interpersonal synchrony (lead advisor) and dance (co-advisor).The results of this project will open up new avenues to explore the therapeutic potential of interpersonal synchrony for FM and other c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dynamic regulation of cytokine signalling in lymphocytes during inflammation', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Cytokines are key regulators of immune responses and inflammation. However, excessive pro-inflammatory cytokine stimulation promotes chronic inflammatory pathologies. Commonly used cytokine-neutralizing therapeutic drugs cause severe side effects and in some patients are not effective. We thus expect that study of the intracellular signalling triggered by cytokine stimulation will provide new, more selective and effective therapeutic targets. DCS will focus on human protein tyrosine phosphatases (PTP) and suppressors of cytokine signalling (SOCS), which are important regulators of immune cell function. Research on PTP is particularly relevant, due to the large number of these phosphatases expressed by lymphocytes and the unknown function of many of them in the cytokine signalling that affects lymphocyte activation in health and disease. Although intracellular phosphorylation levels are essential for normal lymphocyte activation while preventing disease, the significance of phosphorylated SOCS species in these processes is poorly understood, and the PTP that regulate their levels are unknown. We will thus initially determine PTP and SOCS expression profiles associated to rheumatoid arthritis (RA), as a model of an inflammatory disease. Once potential genes involved in the pathology are known, functional genomic approaches will be developed to screen PTP and SOCS for regulators of cytokine signalling during activation of T and NK cells, which are involved in inflammatory disease development. We will further screen PTP for regulators of SOCS phosphorylation to understand their role in lymphocyte activation.  DCS will use advanced microspectroscopy techniques on live cells to study the molecular dynamics of cytokine signalling regulators at the T cell and NK cell immunologi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Formulations and Computational Engineering'.

assistant: **Concept**

The FORCE consortium is a 10 pan-European expert partnership with the objective to develop a integrated Business Decision Support System (BDSS) based on open standards for industries engaged in formulating chemical ingredients.  The generic BDSS is an open framework that connects any existing or future materials models at various levels of complexity and discretion (electronic, atomistic, mesoscopic, continuum and empirical), experimental data sets, and structured and unstructured commercial information (e.g. on cost, forecasting, intellectual property (IP)). In combination with multi-criteria (objective) optimizers (MCO) for key performance indicators (KPI’s) the BDSS generates data driven formulation and product options for facilitating business decision making.  The project has a generic focus but targets 3 specific important industrial sectors as main demonstrators, namely Personal Care (liquid detergents), Insulating Rigid PolyUrethane (PU) based Foams and Industrial Inks (PU-based) for the purpose of focus and generating a real ready to use BDSS available to large, medium and small enterprises alike. The proposed options are tailored for use into problem specific Apps. These provide an additional level of tailored user-friendliness and a data driven operational tool for product optimization, development and quality checks including faster and tailored customer services for the formulators and the providers of formulation components. Accordingly the project is positioning materials modeling as an integrated part of a business decision process. The consortium strives to change the modus operandi of mainly empiricism-based formulation industries into a science and technology and data driven industry by taking advantage of materials modelling and advanced computationa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Safe data-driven control for human-centric systems'.

assistant: **Concept**

Many control systems of the future involve a tight interaction or even symbiosis with the human user. High-impact application domains of human-centric systems include healthcare, mobility, and infrastructure systems. In human-centric systems the human is both, an element of the control system, and a design criterion with individual requirements that need to be satisfied. Safety - despite the high uncertainty of human behavior - and maximization of individual user experience are the primary objectives for control design in human-centric systems. The visionary goal of CO-MAN is to contribute to the fundamental understanding and principled approach to the control of smart human-centric systems. We will develop a novel framework for user-adaptive data-driven control with performance guarantees in order to address the scientific challenges of high uncertainty and individual user requirements. The grand challenge is to unify the two previously separate paradigms of model-based control with its rigorous guarantees but limited modeling base and machine learning algorithms with its flexible modeling concepts but lack of guarantees. The breakthrough enabling idea is to merge probabilistic non-parametric modeling techniques from statistical learning theory with novel risk-aware control methodologies while including active user modeling. The game changer is the current push towards reliable machine learning with novel results on theoretical bounds for learning behavior. Because of favorable properties we will focus on Gaussian Processes to model user behavior and preferences and translate the naturally quantified model uncertainty into closed loop behavior guarantees through a confidence-driven human-interactive control approach. The PI is in a perfect position to achieve the envis