RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Quantitative Analysis of the Hourglass Model of Evolution of Development' (HOURGLASS) under Seventh Framework.

assistant: **Objectives**

The observation that different species within one animal phylum resemble one another in the course of embryonic development fascinated scientists since the dawn of developmental biology. Already in 1828, Carl Ernst von Baer formulated his third law of embryonic  development, later extended into the hourglass model that recognizes the phylotypic stage during mid-embryogenesis as the most constrained period of development, preceded and followed by greater morphological divergence. The arguments for the existence of the developmental hourglass come primarily from comparative morphological analysis of vertebrate embryos and are, to the large extent, qualitative.This proposal describes experiments designed to test the hourglass model quantitatively using sequenced Drosophila species as a model system. The approach is unique, because by focusing on a set of highly similar species, it will be possible to precisely quantify the differences among them and use statistical and genetic modeling approaches to evaluate the hourglass hypothesis.The divergence of genome expression and embryo morphology will be evaluated before, during and after the phylotypic stage, using deep sequencing and high-resolution microscopy combined with advanced image analysis. The two sets of measurements will be linked through cross-species, reverse genetic manipulation of the genomes, attempting to establish a causal chain of events from sequence divergence, through divergence in gene expression patterns to the divergent phenotype of the embryo.The quantitative analysis of the developmental hourglass will provide conclusive evidence for or against the existence of the constraints in gene regulatory networks underlying the phylotypic stage and shed light on one of the most fundamental laws in biology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cellular and molecular mechanisms of metabolic immune activation triggering non-alcoholic steatohepatitis (NASH) and HCC' (NASH).

assistant: **Innovation**

Overweight and metabolic syndrome are reaching pandemic dimensions in industrialized countries and are rising in developing countries. Clinically these diseases can manifest in non-alcoholic fatty liver disease (NAFLD), the most frequent liver disease world-wide. A significant number of NAFLD patients develop non-alcoholic steatohepatitis (NASH), fibrosis and hepatocellular carcinoma (HCC), making NASH-driven HCC the most rapidly increasing cancer in the USA, with a similar trend in Europe. While HCC is the second most common cause of cancer related death, the mechanisms triggering NASH and subsequent HCC are poorly understood and efficacious therapies are lacking. My group has strong expertise in inflammation-driven HCC (e.g. by Hepatitis B, C viruses). Recently, we have established a mouse model of NASH-driven HCC recapitulating human pathology in the context of metabolic syndrome. We demonstrated for the first time that CD8+ T- and natural killer T (NKT)-cells become activated during metabolic syndrome, cross-talk with hepatocytes and alter hepatic lipid metabolism causing NASH and HCC. We found an identical profile of CD8+T and NKT-cell activation in human NASH underlining the clinical relevance of our model. As the mechanisms of immune cell activation in NASH and transition to HCC remain unknown, this research proposal aims to (1) Identify the priming cell types in metabolic CD8+ T-, NKT-cell activation and the molecular mechanisms of immune cell-hepatocyte crosstalk. (2) Determine the role of antigen recognition and danger- or pathogen-associated molecular patterns in NASH/HCC. (3) Identify the environmental and genetic determinants of NASH to HCC transition. Our findings will enhance the understanding of NASH and HCC development by identifying the underlying mech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'An Artificial Visual Cortex for Image Processing' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The ERC starting grant GECOMETHODS, on which this POC is based, tackled problems of diffusion equations via geometric control methods. One of the most striking achievements of the project has been the development of an algorithm of image reconstruction based mainly on non-isotropic diffusion. This algorithm is bio-mimetic in the sense that it replicates the way in which the primary visual cortex V1 of mammals processes the signals arriving from the eyes. It has performances that are at the state of the art in image processing. These results together with others obtained in the ERC project show that image processing algorithms based on the functional architecture of V1 can go very far. However, the exceptional performances of the primary visual cortex V1  rely not only on the particular algorithm used, but also on the fact that such algorithm “runs” on a dedicated hardware having the following features: 1. an exceptional level of parallelism; 2. connections  that are well adapted to transmit information in a non-isotropic way as it is required by the algorithms of image reconstruction and recognition. The idea of this POC is to create a dedicated hardware (called ARTIV1) emulating the functional architecture of V1 and hence having on one hand a huge degree of parallelism and on the other hand connections among the CPUs  that reflect the non-isotropic structure of the visual cortex V1. Such a hardware that we plan to build as an integrated circuit with an industrial partner will be a veritable artificial visual cortex. It will be fully programmable and it will be able to perform many biomimetic image processing tasks that we expect to be exceptionally performant.ARTIV1 will come to the marked accompanied by some dedicated software for image reconstruction and image recogn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Socio-Economic Metabolism PATHways for sustainable metal cYcles'.

assistant: **Concept**

SEMPATHY aims to develop and apply a multi-material, mass balance-consistent, composition-aware, and process simulation-based method called Material Pathway Analysis to provide the basis for modelling, simulating, and optimising sustainable global material cycles for technology metals. SEMPATHY addresses the urgent challenge of global metal cycles not being closed and the environmental impacts of metal production and processing becoming more relevant globally. At the same time, global demand for technology metals rises due to the shift to renewable energy, electromobility, clean energy-intensive industry, digitalisation, and aerospace. The SEMPATHY project promises a revolutionary better understanding of global anthropogenic metal cycles and, for that purpose, develops a better modelling framework for examining metals' pathways in the anthroposphere. SEMPATHY leverages new information on the first and final use of metals and metalloids in materials, components, and products. It creates a database for the elemental composition of these materials, components, and products. The project uses process simulation to identify composition-dependent processes and recycling yields for technology metals. By providing access to these yields to sociometabolic research, it identifies optimisation potentials in the circular economy. SEMPATHY creates a new revolutionary modelling framework that allows the development of a new Material Pathway Analysis methodology that provides a systemic view of global metal cycles and allows tracing metals even within their use as alloying elements, contaminants, or waste streams. These metal pathways will be visualised through interactive maps generated using the data and computational methods developed throughout the project. SEMPATHY creates the bas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Automotive Tested High-voltage Embedded Non-volatile memory Integrated SoC', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

More than 20% of the value of each car already comes from embedded electronics. Keeping costs and space for additional functionality low requires further integration of electronic components such as low and high voltage devices and memory on a single System-on-Chip (SoC). SoC technologies for segments with lower reliability requirements are already available. However, there are no cost-effective technologies yet combining all of the harshest automotive reliability requirements for full SoC integration of powertrain ICs for engines, starters, alternators, etc. This barrier to powertrain IC SoC integration inhibits cost reduction and introduction of  more fuel efficient cars. <br/>The purpose of ATHENIS is to provide proof of concept for the industry's first SoC technology platform that can surmount these integration barriers. The ATHENIS SoC technology platform is intended to be the first in meeting the combination of all of the harshest requirements including full reverse polarity capability at the low cost of CMOS, application voltages up to 120V, currents up to 10A, temperatures up to 200°C, embedded non-volatile memory, chip-level ESD up to =8kV HBM, and high logic gate densities. <br/>This will be achieved by combining HVCMOS technology from austriamicrosystems AG with MEMS-based Nanomech" embedded Non-Volatile Memory (eNVM) technology from Cavendish Kinetics. Innovative (patent pending) add-on technology modules such as reverse polarity HVCMOS and =8kV ESD structures for HVCMOS as well as automotive extensions for Nanomech will be developed.  An alternator-like demonstrator with and without eNVM is selected for a worst case proof of concept. eNVM will enable "flexibility" to software-configure alternator systems for multiple car platforms. Valeo Electrical Systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Sensing and Communication Orchestration Protocols Enhancing Sustainability'.

assistant: **Objectives**

Future wireless networks will be the cornerstone of smart cities, providing ubiquitous connectivity to countless devices capable of communicating, sensing, and processing vast amounts of environmental data. These capabilities will enhance urban life by improving safety and sustainability by monitoring energy use, natural hazards, and public health factors while coordinating traffic via precise localization and tracking.While 5G faces challenges with inconsistent connectivity and limited sensing, 6G is poised to overcome these limitations through Integrated Sensing and Communication (ISAC). Cell-free massive multiple-input multiple-output (CF-mMIMO) networks, which eliminate fixed cellular architecture, offer scalable orchestration of access points, significantly enhancing connectivity and sensing capabilities.Yet, the research in network protocols enabling ISAC within CF-mMIMO networks is still in its early stages, requiring a sophisticated approach to harmonize physical layer signal processing with higher-layer access and resource management. SCOPES, leveraging the expertise of the University of Pisa in communication and Chalmers University of Technology in sensing, aims to fill this gap by designing sustainable cross-layer protocols. The project will focus on three key areas: investigating Medium Access Control functions to integrate sensing as a 6G feature; developing energy-efficient resource allocation for ISAC CF-mMIMO networks, and designing a cross-layer protocol to minimise energy consumption while meeting both sensing and communication performance requirements. The outcomes will be validated using open-source simulation tools, supporting future research and driving innovation in sustainable wireless technologies. SCOPES will position the researcher as a pionee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Methodology and assessment for the applicability of ARINC-664 (AFDX) in Satellite/Spacecraft on-board communicatION networks'.

assistant: **Objectives**

ARINC-664 Part 7 specification (AFDX) provides the enabling technology for network I/O in Integrated Modular Avionics (IMA) architectures, since it is designed based on the IMA concepts and requirements (ARINC 653 specification), already an ESA roadmap (i.e. IMA4Space project). In order to avoid the lack of flexibility, scalability, reliability and to improve security and qualification process in spacecraft on-board data networks, ARINC-664 (AFDX) could be the solution by offering hardware assisted service, determinism and standardisation as a minimum. Additionally AFDX has been validated and is in use today in the European avionics industry, which has in some areas quite similar requirements with the space domain, in which could be more easily adopted (over SpW, or directly Ethernet for space).MISSION aims (1) to define the methodology for applying ARINC-664 (AFDX) in on-board spacecraft/satellite communication networks, (2) to define the interfaces/modifications to existing on-board I/O subsystems and (3) to implement and validate an experimental prototype ARINC-664 (AFDX) network for spacecraft on-board communications.The MISSION project aims to apply the IMA avionics concept on spacecraft, together with highly deterministic interconnected on-board network (ARINC-664, AFDX).  It will constitute an enabling technology harmonization and standardization action. Together with an intrinsic improvement of systems performance, product assurance and reliability, it is expected to provide multiple benefits at all industrial level such as standardized and configurable systems, products and technology elements, easier and faster integration of complex systems, larger procurement basis, easier sub-contracting scheme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Smart Protein for a Changing World. Future-proof alternative terrestrial protein sources for human nutrition encouraging environment regeneration, processing feasibility and consumer trust and accepta'.

assistant: **Concept**

It is undeniable that protein is an indispensable part of the human diet, but the way we produce and consume it today presents many challenges, in terms of both global consumption patterns and their social, environmental and economic impacts. Providing a growing global population with healthy diets from sustainable food systems is therefore an immediate challenge. SMART PROTEIN aims to industrially validate and demonstrate innovative, cost-effective and resource-efficient, EU-produced, nutritious plant (fava bean, lentil, chickpea, quinoa) and microbial biomass proteins from edible fungi by up-cycling side streams from pasta (pasta residues), bread (bread crust) and beer (spent yeast and malting rootlets) industries. The alternative SMART protein will be used for the production of ingredients and products for direct human consumption, through developing future-proofed protein supply chains with a positive impact on bio-economy, environment, biodiversity, human nutrition, food and nutrition security and consumer trust and acceptance. These priorities will be addressed through global partnerships forged with consortium members from Europe, North America, Israel, Thailand and New Zealand to develop and demonstrate a climate-smart, sustainable protein-food system for a healthy Europe. We will harness plant and microbial protein knowledge to significantly enhance the sustainability and resilience of a new European protein supply chain, improve professional skills and competencies, and support the creation of new jobs in the food sector and bioeconomy.


**Keywords:** New plant protein, Microbial biomass protein, Food Science, Food Technology, Food and drink processing, Food quality and safety, Regenerative agriculture, Sustainability, Molecular Biology, Innovation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Breeding tools for durable resistance to root-knot nematodes (meloidogyne spp.) of coffee varieties in latin america' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

By a multidisciplinary approach, the present project aims at improving the resistance of coffee varieties (Coffee Arabic) to root-knot nematodes (Meloidogyne spp.) which constitute the most serious constraint to coffee Cultivation in Latin America. We intend to obtain genetic durable resistance through the combined development of i) varieties (either cultivar or rootstock) associating complementary well-characterised resistance genes, and ii) optimised variety-deployment strategies based on a careful characterisation (geographical distribution, virulence and pathogenicity) of root-knot nematodes populations damaging coffee trees. In so doing, the project would significantly contribute to the sustainable improvement of coffee production, which constitutes a major economic and social activity in Latin America.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Self organization in fracture and transport phenomena in complex materials' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Dynamical transport processes coupled to degradation in random mat- erials will be studied. In particular, we will concentrate on the two following problems: l)Fracture due to thermal shocks in brittle materials, and 2) stress-induced permeability changes in porous media during flow. The first problem arises in many practical situ- ations such as when pouring hot tea into a cold glas, or in any kind of industrial process where equipment is exposed to rapid temperature changes. The second problem concerns how an external deformation changes the flow field in a porous material, and how this change acts back on the stress field. This is a problem that for example is of concern to oil recovery in connection with load changes in the region near bore holes. Our approach is theoretical, and will be supported by extensive numerical modeling. It will form the basis for design of experi- ments to be conducted at the University of Oslo. Key words in connection with the theoretical analysis are self Organisation, criticality and scaling.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Implemented MOnitoring system for structural DIsplacement', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

I.MODI aims at exploiting business opportunity generated by the increasing need to have a systematic monitoring system able to control stability of buildings and civil infrastructures. It focuses on the exploitation of EO data to create an added value service where the integration between EO observation (Sentinel 1/Copernicus, COSMO-SkyMed and ESA archive SAR data from ERS-1/2 and Envisat) and ground-based  technologies represents the core of the system and becomes easily accessible from users.I.MODI is expected to overcome the need to develop a specific SAR knowledge (the most significant “cultural” barrier to the adoption of the techniques), leverage scientifically validated practices based consolidated monitoring methodologies to be further evolved into innovative operational prototypes.By exploiting the EO and ground based dataset, 3D numerical maps, and GIS spatial analysis, the I.MODI technology will support the monitoring activity and contribute to damage assessment analysis through the calibration on advanced numerical modelling.The I.MODI project will: i.   define standards for the structural monitoring, damage assessment and infrastructure impact modelling using advanced   EO services & products; ii.  test, prototype and industrialize an innovative range of monitoring services also based on the outcome of the feasibility project carried out within the ESA/BIC Lazio  initiative (already funded and completed), according to user requirements defined by primary European infrastructure managers; iii.  disseminate the project results through a multichannel communication strategy by organizing workshops involving key stakeholders and service users, web based campaigns,  and more traditional communication (e.g. papers and press clippings); iv.  define an appropriate b