RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Model-based methods and tools for Avionics and\nsurveillance embeddeD SystEmS' (MADES).

assistant: **Concept**

MADES aims to develop the elements of a full-fledged model-driven approach for the design, validation, simulation, and code generation of complex embedded systems to improve the current practice in the field.The proposal covers all the phases of the development process: from design to code generation, validation and deployment. Design activities will exploit a dedicated language developed on top of the OMG standard MARTE (Modeling and Analysis of Real-time and Embedded systems), and foster the reuse of components by annotating them with properties and constraints to ease their selection and enforce overall consistency. Validation activities will comprise the verification of key properties of designed artifacts and of the transformations used throughout the development process, and also the closed-loop simulation of the entire system. Code generation will address both conventional programming languages (e.g., C) and hardware description languages (e.g., VHDL), and will adopt compile-time virtualization techniques to smooth the impact of the diverse elements of modern hardware architectures and cope with their increasing complexity.All these aspects will be fully supported by prototype tools integrated in a single framework, and will be thoroughly validated on real-life case studies in the surveillance and avionic domains.  The project also aims to develop a handbook to provide detailed guidelines on how to use MADES tools in the development of embedded systems and promote their adoption.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Prediction of the behavior of potential endocrine disruptors in soil using vitellogenin Elisa assays as biosensors' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Some xenobiotic compounds present in industrial sewage sludges, industrial effluents and waterways have proven or suspected estrogenic and therefore can cause alterations in the endocrine function of fish and other organisms. Such alterations have been observed in major European watersheds. Endocrine disruption seems to correlate to high vitellogenin levels in male fish and thus a vitellogenin-based ELISA assay is likely to give an adequate prediction of endocrine disruptor activity in environmental systems. PRENDISENSOR focuses on the extension of existing knowledge on endocrine disruptors and their detection methodologies in order to understand their behavior and to predict their environmental impact, specifically: - To adapt an existing model description for the behavior of organic pollutants in soils, so that it adequately describes and predicts the bio"-availability of endocrine disruptors in soils and their presence in run-off. The model uses soil characteristics and (bio)chemical properties of the target compounds as input parameters. - To obtain field lysimeter and laboratory data, which quantify and mechanistically describe endocrine disruptor sorption, biodegradation and transport processes in soils from different European climate zones. Data are used to validate the adapted model. - To develop a biosensor, based on increased vitellogenin levels in fish, a biomarker for the presence of endocrine disruptors. To optimize the use of vitellogenin ELISA assays to screen environmental samples for the presence of estrogenic compounds. - To develop a river basin model to predict potential pollution of surface waters by sludge amended soils, which together with measured vitellogenin ELISA data will enable risk assessment for endocrine disruptors in a river basin. PREND
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PERFluorinated Organics in Our Diet' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Proposal summary Anthropogenic perfluorinated compounds (PFCs) have recently gained socio-economic and scientific interest. PFCs constitute a newly emanating group of environmental contaminants, with physico-chemical as well as toxicological properties different from those of other halogenated compounds. PFCs are generally persistent in the environment, and  can be found over a broad concentration range and within most parts of the aquatic and terrestrial ecosystems. Food, produced with natural ingredients, and possibly beverages, including drinking water, are likely to be contaminated with PFCs, giving rise to human exposure. Whether or not industrial food processing and packaging may give rise to additional contamination of food and beverages is currently not understood. Whatever the sources, PFCs have indeed been found to be present at a global scale in blood of the general population. PERFOOD brings together the institutes most renowned in Europe and the Globe for their chemical analytical work on PFCs with experts in food consumption and drinking water quality as well as food processing and packaging.  The aims of the present project are to develop robust and reliable analytical tools including reference materials for the determination of PFCs in food items, and to use these to (i) qualify and quantify PFCs in our diet, employing a large European sampling campaign; (ii) understand how PFCs are transferred from the environment into dietary items, and (iii) quantify the possible contribution of food/beverage contact materials and food and water processing to the overall PFC levels in our diet. The newly gained knowledge will enable us to evaluate the possible routes, including their relative importance, of human exposure to PFCs via our diet, to assess the role of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Neurocomputational determinants of decision urgency in humans'.

assistant: **Concept**

A central question in the behavioural, cognitive and neural sciences is how humans choose between available alternatives (Does this patient have flu, or meningitis? Should I go on holiday to Spain, or Scotland?).  However, much less attention has been devoted to the question of when an agent should decide.  Longer deliberation is more likely to lead to better decisions (because it allows greater accumulation of decision-relevant evidence) but it also incurs a cost (because it delays reinforcement, and increases the chance that deadlines will be missed).  Humans adjust their decision strategy to match the urgency with which a decision should be made, but how they do so is unknown.  In the proposed research, we ask how humans compute the urgency associated with simple perceptual categorisation judgments, and use functional brain imaging to identify neural circuits involved in these computations.  Our approach to this question is grounded in formal mathematical models of the decision process, allowing us to compare human performance to that of an ideal observer that computes decision urgency in order to maximise economic outcome.  Using tools from experimental psychology, we measure the sensitivity of healthy individuals to quantities that are relevant for computing decision urgency.  We will then use functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) to ask where they are encoded in the human brain.  Subsequently, we turn our attention to individuals who are prone to make impulsive decisions, using individual difference and pharmacological manipulations.  We ask which decision-relevant information is computed inappropriately in impulsivity, and use fMRI and MEG to ask which brain regions may be responsible for atypical computations. This new ‘co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Transcriptional REGUlation as a mediator of bacterial interactions in the microBIOME'.

assistant: **Innovation**

Bacteria from the gut microbiota constantly interact with a range of abiotic and biotic factors. Perturbations in these factors, such as nutrient depletion or exposure to exogenous microbes, require specific bacterial responses that involve tightly controlled gene expression changes. However, the transcriptional regulation mechanisms promoting such gene expression changes remain poorly understood despite their importance.REGUBIOME will characterize how responses to specific biotic and abiotic stimuli are regulated at the transcriptional level in two health-associated gut bacteria: one probiotic (Lacticaseibacillus rhamnosus) and one pathobiont (Fusobacterium nucleatum, previously linked to colorectal cancer). This project relies on combining experimental platforms of increasing complexity to systematically characterize the responses of these two bacteria to defined biotic and abiotic factors, and to evaluate how these responses impact host health. First, I will develop a novel high-throughput functional screening tool, coupling CRISPR interference, microfluidic platforms for single-cell isolation, and transcriptomic profiling of isolates. By applying this tool to in vitro monocultures, I will reconstruct the first-ever gene regulatory networks in these bacteria and identify mechanisms of response to different abiotic factors. Second, microfluidic co-culturing of these two strains with multiple other bacteria, coupled with metatranscriptomic profiling, will reveal the regulatory mechanisms mediating the interactions with other microbiome members. Lastly, in vivo work in mouse models will shed light on how the host colonic environment impacts gene expression in these health-associated bacteria.Altogether, REGUBIOME will provide proof of the importance of gut bacterial gen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Tracking and guiding artificial enzyme evolution via landscape inference'.

assistant: **Objectives**

Directed evolution is an effective method for protein engineering. The host laboratory is designing innovative techniques for the directed evolution experiments of enzymes, with the possibility to test millions or billions  of variants to be tested at each cycle. In this project, I will introduce the use of full-gene next generation sequencing to supervise the exploration of variants at the sequence level and quantitatively characterize the fitness landscape, with a focus on non-additive effects of mutations into fitness (epistasis). Furthermore, this information will be included in DE protocols to guide a more efficient exploration of the sequence space. The project is a strongly interdisciplinary project consisting of experimental synthetic biology, physics modelling and bioinformatics analysis. It is focused in the study of DNA processing enzymes such as polymerase and endonucleases. The proposal includes the development of specific tools which should have an immediate impact on the scientific  community: i. extend the applications of next generation sequencers to characterize  full length genetic libraries of protein variants ; ii. adapt quantitative methods, previously developed for sets of structurally homologous proteins and derived from Potts model to study the catalytic properties of  during directed evolution. iii. develop a new experimental protocol to control the number of mutations in libraries. The analysis will provide a better understanding of the topology of the fitness landscape of an enzyme, and its distortions under selective pressures, thereby clarifying the relations between sequence,function and evolution in proteins.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Increasing the awareness on INNOvation in the European CONStruction sector' under Fifth Framework.

assistant: **Concept**

The INNOCONS project aims to assist European construction SMEs to improve their technological standing point, and to facilitate the international co-operation with other SMEs and technological centres or universities. So as to achieve such a major goal, members of the INNOCONS consortium will foster the participation of these firms in innovative projects under the scope of the European Commission initiatives. To reach this goal, relevant actions will be carried out to identify specific needs of SMEs belonging to the construction sector, analyse their capabilities, and inform them of the chances of participating in RTD projects, and directing them towards the most suitable Community instrument for such participation. After these brief instructions, INNOCONS members will assist these SMEs during their project definition and proposal preparation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'How perceptual history shapes vision: neural mechanisms and predictive properties' to be submitted under Horizon Europe.

assistant: **Abstract**

What we see at any given time is not solely determined by the information currently reaching our eyes. The visual system is indeed thought to leverage on perceptual history – i.e., the stimuli saw in the recent past – to contextualise and optimise perception. The incorporation of past stimulus information into perceptual processing has important consequences, shaping how we perceive external objects and events according to the context in which they are embedded in. Namely, perceptual history can bias perception in an attractive way, making a stimulus to appear more similar to its preceding one than it actually is. The nature and mechanisms of attractive perceptual history effects are however unclear, due in part to seemingly conflicting findings suggesting either that the bias is perceptual in nature, occurring in low-level sensory areas, or a cognitive effect based on decision-making. With PreVis, I will provide a new perspective on these effects, proposing and testing a novel hypothesis. Namely, instead of being uniquely based on past information as currently assumed, attractive perceptual history biases may entail an active predictive mechanism. In this scenario, the attractive bias would arise from a prediction based on past stimuli (rather than the past stimuli themselves) performed by high-level brain areas, and affect the processing of sensory information in lower-level areas. In PreVis, I will use psychophysical techniques coupled with electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), to test this hypothesis and assess the neural signature and correlates of perceptual history and predictive processes. The innovative perspective of PreVis represents an important step forward from the current state of the art, and the project has the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Enabling certification by analysis' (ECERTA) under Sixth Framework.

assistant: **Objectives**

Simulation is increasingly impacting on many stages of the aircraft development process. However, the exploitation of the Virtual Aircraft for certification has been limited. This is problematic for several reasons, including the development of highly optimised designs, novel configurations which have very little history to base certification on and the high cost of a lengthy test programme.To exploit simulation for certification places a high demand on the methods. First, the complete system as to be represented and with a sufficiently high fidelity. Secondly, there has to be some way of rationalising differences with measurements and assessing the influence of uncertainty in system parameters. Thirdly, searches for problem areas must be done with high computational efficiency and with the minimum of previous knowledge.The proposal is to establish an Excellence Team which considers the advancement of certification by analysis by considering aeroelastic stability certification as an example.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Hydrogen Cyanide and Thiocyanate Transformations in Anoxic Aquatic Systems' (THIOCYANOX) under Seventh Framework.

assistant: **Objectives**

Hydrogen cyanide (HCN) is a toxic compound, whose sources in natural aquatic systems are mostly of anthropogenic origin. Although a variety of organisms, most notoriously vascular plants, produces HCN, its release from natural sources is not considered to be an important source of HCN contamination of aquatic environments. Recent results of my research showed that concentrations of HCN, which are toxic to aquatic species, are released in the anoxic ferruginous and sulfidic sediments of the Delaware Great Marsh (DGM) from the roots of cord grass Spartina alterniflora. The main sinks for HCN in the DGM sediments are the formation of metallo-cyanide complexes and reaction with reactive zero-valent sulfur species, which lead to the formation of thiocyanate.I propose to conduct a study to clarify a) the prevalence of HCN release in various aquatic systems; b) which biogeochemical processes control the release and scavenging of HCN in natural aquatic systems; and c) the kinetics of chemical reactions underlying reactions of HCN in natural aquatic systems.In the first stage of the research representative examples of various types of oxygen-depleted aquatic systems (meromictic lakes, marine water bodies with restricted circulation, ocean upwelling zones and sedimentary pore-waters) will be assayed for the presence of relatively stable products of HCN transformations, i.e., thiocyanate and strong metallo-cyanide complexes. The next stage will include a detailed study of biogeochemical mechanisms of cyanide release and transformations in three selected systems. These studies will be accompanied by laboratory experiments to determine the rates of reactions between metallo-complexed and adsorbed cyanide with zero-valent sulfur species abundant in natural aquatic systems (e.g., soli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'The stress granule machinery controls metabolic signalling through mTOR at steady-state'.

assistant: **Objectives**

mTOR kinase is an oncogenic master regulator of metabolism and cell growth and is known to reside in two multiprotein complexes. Upon stress, mTOR is inhibited by stress granules (SGs), which recruit mRNAs and signaling factors to promote survival. Current work largely addresses the functions of SG proteins under stress, focusing on their RNA binding properties and SG assembly. However, non-stress functions are emerging. I propose that SG proteins have prime functions in mTOR signaling at metabolic steady-state, in the absence of SGs. Our preliminary data show that core SG proteins bind mTOR at steady-state and suggest that they are key controllers of mTOR. In BEYOND STRESS, we will investigate SG proteins as a novel class of mTOR regulators at steady-state.By means of deep proteomics, proteo-metabo-flux, RNASeq, systems modelling, mechanistic and cell bio-logical studies, we will identify and functionally characterize the SG interactome of the mTOR complexes. We will delineate the steady-state inputs that signal through SG proteins to mTOR, and we will unravel the mechanistic interplay through which SG assembly impinges on metabolic signaling upon stress. As levels of core SG proteins correlate with cancer outcome, we will explore their linkage with metabolic signaling, prognosis and drug response in breast cancer. BEYOND STRESS is ground-breaking as (i) it links SG protein research in stress to steady-state mTOR signaling; (ii) a unifying paradigm of mTOR regulation at steady-state and stress will open new horizons for research on metabolic signaling; and (iii) SG proteins are emerging as markers and targets for oncogenic signaling through mTOR. While focusing on mTOR and breast cancer, BEYOND STRESS will likely translate to further networks and tumor entities, openin