RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Validation of Open organ-on-chip Technology for End user applications' under Horizon 2020.

assistant: **Concept**

Organ-on-Chips, and more general microphysiological systems, are believed to revolutionize the way we develop drugs or select personalized therapies. Recapitulating human response both from healthy and diseased individuals potentially even enables ‘clinical trials in-a-dish’. While research in this field is thriving and commercial start-ups have been founded, adoption from end users is staying behind due to a number of reasons: i) lack of standardization making chips not compatible with each other, ii) lack of automation which limits the throughput and user-friendliness of the systems and iii) lack of support for sensor integration. The Twente Organ-on-Chip Platform (TOP) is designed to overcome these hurdles and has been developed for internal use during the ERC project VESCEL. During interaction with other researchers and companies within the Organ-on-Chip field they expressed their interest in a more standardized, automated platform that also supports sensor integration. Since it would require a number of steps for them to be able to use the platform in their existing environment we here suggest the ‘open-TOP’ ERC Proof of Concept project where we aim to commercialize the application of the Twente Organ-on-Chip Platform (TOP) and facilitate end users to use TOP in real world contexts. To reach this objective we need to develop a robust interconnect, validate and identify difficulties in making a third party chip TOP-compatible, validate the use of TOP for a biological experiment and finally determine the commercialization strategy for TOP. We believe TOP can help more end users to adopt Organ-on-Chip as a technology in their lab because in contrast to current setups, the open technology of TOP supports chips from third parties are inter compatible, multiplexable and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Commercial feasibility study of a technology that multiplies blood stem cells to increase the success of transplants for cancer treatment' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

StemCell2MAX is a biotechnology start-up that owns a proprietary solution for multiplying blood stem cells. Blood stem cells are required for both research and blood cancer treatment, but are scarce resulting in limited transplants (34% of patients do not find a donor), patient death (6-15%) and limitations at research level (12.500 groups lack cells for their studies). StemCell2MAX addresses this enormous demand from patients, cord blood banks, hospitals and researchers in an estimated €3 billion potential market (33% CAGR). No solution for blood stem cell multiplication is available for clinical purposes and those that are currently used for research purposes compromise cell quality. StemCell2MAX has developed a product that multiplies these cells while assuring their quality (20x better results compared to state of the art, as published in Nature). Currently, StemCell2MAX markets a research use only product (€600M market) with a growing sales track record, both in EU and USA. Following the technology’s market acceptance and scientific recognition, StemCell2MAX is preparing their solution for the €2.4B clinical market. The innovation is protected in EU, USA and Japan for blood stem cell maintenance, expansion or transplantation, for both research and clinical use. StemCell2MAX won the “most investable company” award during the first Horizon 2020 – Invest Horizon Global Investor Summit in November 2015.Specific objectives:• To develop a business plan and marketing strategy for clinical application• To explore strategic partnerships for development and commercialisation• To explore the clinical validation strategy/clinical trial design• To develop a strategic development plan in agreement with reimbursement policies Expected outcomes:• A business plan and optimal route-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Intelligent Low-Cost Real-Time Nanomagnetooptical Integrity Monitoring and Sensing System for Asset Integrity Management'.

assistant: **Innovation**

EQS aims to deliver a low-cost highly sensitive real-time remote monitoring tool for intelligent structural integrity monitoring, for the Oil, Gas and Energy markets. This new disruptive market solution, based on nanotechnology, will increase the resilience of critical energy installations and networks, allowing the reduction of human losses, avoiding energy production disruption, minimizing environmental and economic impact and material damage from natural and man-made disasters.Proximally 60% of the incidents in the EU’s hazardous industries are due to integrity failures and in 50% of these cases, ageing is a significant factor. Structural integrity real-time monitoring can provide far greater integrity knowledge then traditional inspection methods, critically increasing safety with significant maintenance cost reduction through the early detection of problems.The NANO concept is to provide a cost-efficient real-time monitoring solution, capable of performing asset volumetric evaluation, significantly increasing the resilience, life span and safety of the client’s critical installations and networks. This tool will enable the screening of degradation in large pipelines, process equipment, industrial plants, terminals and offshore structures, providing means to perform evaluation of areas that would otherwise be inaccessible. Furthermore, it will be possible to obtain real-time detailed qualitative and quantitative information and 3D visualization of the asset’s integrity. The solution combines nanotechnology with magnetostrictive generated guided waves and high sensitivity sensing Fiber Bragg Gratting. Through an advanced material fabrication process, EQS creates the first low cost monitoring solution with a higher sensitivity level than any other inspection tools. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Discovery of novel chiral magnetic molecular materials for the study of magnetochiral effects'.

assistant: **Concept**

Interest in new molecular materials with sophisticated properties is continuously increasing. In particular, the association of magnetic properties with another functionality has given rise to a variety of fascinating polyfunctional materials, such as photomagnets, magnetic liquid crystals or superconducting paramagnets. The addition of chirality to molecular magnetic materials, could give rise to such applications as multiferroics, but also help shed light on such fundamental questions as the origin of the homochirality of life. In this project, we would like to explore the synthesis of novel chiral nanomagnets to study the interaction of incident radiation and magnetic field. For this work, we have chosen three classes of molecular nanomagnets demonstrating helicoidal chirality: 1) Extended Metal Atom Chains (EMACs), 2) Chains of Extended Metal Atom Chains (CEMACs) and 3) Star-type Single Molecule Magnets (SSMMs).Dr. Miguel Cortijo, received a PhD from UCM of Madrid, where he studied coordination polymers, and is currently performing a postdoctoral work in the CEMES in Toulouse on chiral coordination compounds. His background in coordination chemistry, crystallography and magnetism, as well as his creativity and leadership will permit the rapid development of a new topic. This project will be carried out in the M3 group of the Centre de Recherche Paul Pascal (CRPP) in collaboration with the MMC group at the Institut de Chimie de la Matiere Condensée (ICMCB) in Bordeaux. Supervised by CNRS researchers Dr. Elizabeth Hillard and Dr. Patrick Rosa, this project will benefit from the expertise and instrumentation found the respective institutes. Furthermore, collaboration with Eric Freysz (LOMA, Bordeaux), Andrei Rogelev (ESRF, Grenoble), Philippe Sainctavit (IMPMC, Paris)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Apolipoprotein A-I and modulation of T cell functions' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The pathogenesis of atherosclerosis involves inflammation and immune reactions. T cell responses contribute to local inflammation and growth of the atherosclerotic plaque. As intensified inflammatory activation may lead to local proteolysis, plaque rupture, and formation of a thrombus, studies of conventional and regulatory T cell functions during hypercholesterolemia are of outmost importance.Low levels of high-density lipoprotein (HDL) cholesterol are associated with inflammatory and immune disorders, including atherosclerosis. Although accumulating evidence suggests that HDL has anti-inflammatory properties, and functions as a part of the immune system, the mechanisms by which HDL inhibits atherosclerosis are not yet fully understood.Here, I propose to study the potential role of apoA-I in regulating the function of conventional and regulatory T cells. To this end, I will use hypercholesterolemic LDL receptor (LDLr) -/- and apoA-I-/- double knock-out (DKO) mice that develop severe atherosclerosis and display autoimmune phenotype, and, as a control, (LDLr) -/- single knock-out (SKO) mice fed atherogenic diet to study: 1) the role of apoA-I in regulating T cell motility, 2) the influence of apoAI on adhesion of T cells to antigen-presenting cells, 3) the effect of apoA-I on T-cell signaling molecules that regulate T cell motility and adhesion, 4) the relation between apoA-I and apoA-I-affected T-cell signaling molecules in vivo. These complementary approaches will allow me to investigate the role of apoA-I on regulating T cells functions, and will be indispensable to assess an impact of apoA-I-affected T-cell signaling molecules on atherosclerosis and autoimmune diseases.As conventional T cells critically modulate atherosclerosis by promoting inflammation, and regulato
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Regional Absorptive Capacity and the Contribution of Multinational Corporations to Knowledge Production in the Local Economy within a Developing Economy Context: The Case of China' in the context of a Seventh Framework call.

assistant: **Objectives**

Geographers, economists, and planners have recently begun to emphasise knowledge production as an important source of both regional and national economic growth. In this context, the subsidiary of a multinational corporation (MNC) can be seen as a conduit for the importation of superior knowledge. In developing countries, where knowledge bases are weaker than in advanced economies, MNCs are often expected to be a primary source of innovation.This study examines whether this view is supported by the evidence based on an analysis of China. This research distinguishes itself from the existing literature by focusing on (1) a region (rather than a firm) as a unit of knowledge absorption and (2) knowledge flow as such, rather than its outcomes (such as productivity improvement).The project’s objective is twofold. First, it measures an MNC subsidiary’s contribution to local knowledge production and compares it against that of local firms. Second, it explains the difference among cities’ and regions’ ability to learn from MNC subsidiaries using an econometric model.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'PROMOTING ENERGIESPRONG RENOVATIONS AND ONE-STOP-SHOP RETROFIT CONCEPTS IN HIGHLY EFFICIENT NZEBS IN ENERPHIT STANDARD, TO MAKE RENOVATION MORE RELIABLE, FASTER AND COST-EFFECTIVE'.

assistant: **Concept**

The outPHit project aims to support building owners and housing companies in performing reliable, quicker and more cost-effective deep retrofits. Working on and collecting findings from real refurbishment projects, outPHit will promote renovation concepts like the Energiesprong approach or one-stop-shop solutions, but in highly efficient quality to NZEBs in EnerPHit standard, to stakeholders among neighbourhoods, municipalities, financing institutions and the building supply chain. It will lay the ground for regional players, particularly SMEs, to enter the market as providers of innovative out-of-the-box solutions, either consisting of conventional renovation concepts or of highly efficient prefabricated systems. While the focus is on residential buildings, most of the proposed approaches will also apply to non-residential buildings, thus widening the scope to educational and office buildings.


**Keywords:** EnerPHit, Deep retrofits, RES implementation, Pre-fabrication, Passive House Principles, Quality Assurance, Success Monitoring, Case Study Projects, Certification schemes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Remote Ischemic Conditioning in Lymphoma Patients Receiving Anthracyclines.' under Horizon 2020.

assistant: **Concept**

The increasing life expectancy of the population and the development of effective therapies result in a growing population of aged cancer survivors, which frequently have comorbidities for developing heart failure (HF). Anthracyclines (AC) are still first line treatment for many cancer types, but up to 35% of patients who received them develop cardiotoxicity and HF. The trade-off between cancer and chronic HF is of massive psychological burden for patients, and of devastating economic consequences for healthcare systems. We aim to test the efficacy of a novel intervention (remote ischemic preconditioning) to reduce the incidence of AC-induced HF. We have selected Non-Hodgkin lymphoma as the target population, since it is diagnosed at advanced comorbid age in both genders. This will also allow us study gender differences in AC-induced HF. A phase II randomized clinical trial enrolling 608 patients undergoing AC chemotherapy will be done. Primary endpoint will be based on serial cardiac magnetic resonances exams. Taking advantage of the recruited population and data gathered, we will further validate 2 novel cardiac magnetic resonance imaging methods: a novel early marker of cardiotoxicity, and a new sequence allowing a massive reduction of acquisition time. We will also study a personalized strategy to empower patients in clinical trial execution, which includes Patient-Reported Outcome and Experience Measures (PROMs and PREMs). Our final goal is to reach the patient level by implementing the novel strategy at the clinical level while paving the way for a future large phase III trial. For this endeavour, we count on a multidisciplinary consortium, where different stakeholders of this process are part of the study, from scientists to industry, and from healthcare provider
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Training  in Multiscale Analysis of multi-Phase Particulate Processes (T-MAPPP)' (T-MAPPP) targeting Seventh Framework.

assistant: **Abstract**

Dry, wet and multiphase particulate materials constitute over 75% of raw material feedstock to industry. Despite their significance, many industrial particulate processes display unpredictable behaviour due to both their multiscale nature and the coexistence of different phases: this leads to undesirable losses in resources, energy, money and time. Considerable progress can be achieved using multiscale analysis and modelling to provide both visual and quantitative details of the dynamics of multiphase particulate systems. However, immature predictive capabilities, together with a lack of expertise and education in this developing field, hinder the adoption of these technologies. To address this skills gap and to initiate further advances in the field, it is crucial that a coordinated and intersectoral approach (combining different industrial sectors and fields of science) is taken, broadening the portfolio of skills currently retained within the EU research community. The T-MAPPP network brings together 15 leading European organizations in their respective fields, including 10 industrial companies (4 of which are SMEs) and stakeholders ranging from agriculture/food processing, consumer/personal care, chemicals/pharmaceuticals to software and equipment manufacture, to foster and develop a pool of ESRs and ERs who can transform multiscale analysis and modelling from an exciting scientific tool into a widely adopted industrial method. Through the delivery of sound scientific training and exposure to both Academic and Industrial environments, each of the 15 fellows recruited will be equipped with the multidisciplinary and transferable skills needed not only to initiate further advances in the field, but to become future leaders in Multiscale Analysis (MA) of multiphase Part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Probabilistically Analysable Real-Time Systems'.

assistant: **Objectives**

There is an ever-increasing demand both for new functionality and for reduced development and production costs for all kinds of Critical Real-Time Embedded (CRTE) systems (safety, mission or business critical). Moreover, new functionality demands can only be delivered by more complex software and aggressive hardware acceleration features like memory hierarchies and multicore processors. However, these greatly increase system complexity, making it much more difficult to analyse applications for their temporal behaviour. Another key problem of CRTE systems is the need to prove that they operate correctly, satisfying all temporal constraints. The current generation of platforms, despite being based on comparatively simple and old processor technologies, are already extremely difficult to analyse for their temporal behaviour, and resulting errors in operation, cost EU industries billions of Euros annually in warranty and post-production costs.<br/>The PROARTIS thesis is that the timing behaviour of systems that use advanced hardware features like multicore CPUs and complex memory hierarchies can be analysed effectively by probabilistic timing analysis techniques that reduce the risk of temporal pathological cases to quantifiably negligible levels. Preliminary research results in cache replacement policies by members of the PROARTIS consortium strongly support this claim. PROARTIS defines new hardware and software architecture paradigms based on the concept of randomisation that, with minimal changes to current processes and methods, guarantee timing behaviours that can be analysed with probabilistic techniques. PROARTIS uses a holistic approach in which probabilistic analysis extends from hardware design, compiler and real time operating system to applications. On top of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dorsolateral prefrontal cortex contribution to working memory and willed action - a positron emission tomography activation study' (1994-1998).

assistant: **Innovation**

The cognitive functions carried out by human dorsolateral prefrontal cortex (Brodmann's areas 46 and 9 in particular) are not sufficiently understood. Alternative hypotheses have been made to suggest that this is either the seat of self-generated (willed) action (Frith et al., 1991), or the anatomical locus for working memory (Petrides et al., 1993). A problem with the working memory hypothesis of Petrides was that his language tasks involved monitoring of string of 10 digits, which exceed average short-term span. In this experiment we will use positron emission tomographic measurements of regional cerebral blood flow to study whether a distinction can be drawn in functional anatomical terms between these two hypotheses. In the same experiment on the same subjects we shall try to tease apart the anatomy of executive functions and short-term storage by comparing the pattern of activation associated with a random digit generation task and a a short-term memory task for digits which do not exceed span. Each of these tasks will be compared with appropriate baselines.