RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'NEXT GENERATION OF ADVANCED COMPOSITE MATERIALS FOR SUSTAINABLE RETROFITTING OF STRUCTURES'.

assistant: **Concept**

Owing to the poor seismic design and the absence of strict energy performance regulations, the vast majority of the existing old building stock in seismic-prone areas is not only highly vulnerable to earthquakes, but also energy demanding. Currently, structural and energy retrofitting of buildings is treated separately with no established holistic approach. An integrated retrofitting system using advanced composite materials combined with thermal insulation can improve the seismic and energy performance of buildings and offer savings in application costs (>25%). During the last two decades, the use of fibre-reinforced composite materials for structural retrofitting applications has gained popularity. The recent generations of advanced composites for construction have proven to be very effective in seismic retrofitting of structures. However, they are often expensive, lead to incompatibility issues, and promote the use of cement-based binders, of which the production largely contributes to the global CO2 emissions (5% of global man-made CO2 emissions). The main objective of THORAX is to develop the next generation of sustainable fibre-reinforced composite materials to be used for the combined structural and energy retrofitting of buildings, protecting the residents during earthquakes, whilst increasing their energy performance. The efficiency of this novel retrofitting system will be investigated through a multi-scale experimental campaign accompanied with a detailed numerical investigation. The host organisation has a leading expertise in the fields of fibre-reinforced composites and seismic retrofitting techniques. This project, along with training schemes available at the host university and secondment at a word-class research centre, will create great opportunities f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Optimization of Medical Accelerators' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Cancer is a major social problem, and it is the main cause of death between the ages 45-65 years. In the treatment of cancer, radio therapy (RT) plays an essential role. RT with hadrons (protons and light ions), due to their unique physical and radiobiological properties, offers several advantages over photons for specific cancer types. In particular, they penetrate the patient with minimal diffusion, they deposit maximum energy at the end of their range, and they can be shaped as narrow focused and scanned pencil beams of variable penetration depth. Although significant progress has been made in the use of particle beams for cancer treatment, an extensive research and development program is still needed to maximize the healthcare benefits from these therapies. The Optimization of Medical Accelerators (OMA) is the aim of the here-proposed European Training Network, in line with the requirements of the EC’s Medical Exposure Directive. OMA joins universities, research centers and clinical facilities with industry partners to address the challenges in treatment facility design and optimization, numerical simulations for the development of advanced treatment schemes, and in beam imaging and treatment monitoring.The proposed R&D program ranges from life sciences (oncology, cell and micro biology and medical imaging.), physics and accelerator sciences, mathematics and IT, to engineering. It is hence ideally suited for an innovative training of early stage researchers. By closely linking all above research areas, OMA will provide an interdisciplinary education to its Fellows. This will equip them with solid knowledge also in research areas adjacent to their core research field, as well as with business competences and hence give them a perfect basis for a career in research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel piezoelectirc peptide-based scaffold for 3D cell culture' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Tissue regeneration has emerged as a promising novel therapy for various disease conditions. A key requirement for the implementation of this advanced approach is the efficient, reliable and reproducible growth of 3D cell cultures, including organoid structures. State-of-the-art 3D culture media support the growth of such cultures, yet exhibit several key setbacks, including low reproducibility and limited modularity. Moreover, no commercial piezoelectric media are currently available, thus prohibiting the option of inducing electrical stimulation of the cells via mechanical stimuli, similar to the in vivo function of several tissues. Here, we aim to develop PiezoGel, a biocompatible, reproducible, controllable and piezoelectric medium for 3D cell cultures. The newly-designed medium will be based on two components, a cell-supporting hydrogel and a piezoelectric self-assembled peptide structure. In the scope of the BISON-694426 Advanced ERC project, we identified promising molecular building blocks for each of these components. The Proof of Concept project will focus both on technological development of the PiezoGel matrix and on business feasibility. Thus, the formulation of the newly-designed cell medium will be optimized, and the resulting matrix will be examined for various properties, including mechanical rigidity and piezoelectricity. The growth of diverse organoid cultures, as well as stem cell differentiation, will be further tested and calibrated. Relevant stakeholders will be approached allowing to map the product requirements and expected features directly from the users. In parallel, the regulatory compliance of the PiezoGel medium will be verified, and the relevant material and methodologies will be patented. We envision diverse applications for the PiezoGel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Analysis & Assessment for Critical Infrastructure Protection' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Developed societies have become increasingly dependent on ICT and services.Infrastructures such as information and communication, banking and finance, energy, transportation, and others are relying on ICT and are mutually dependent. The vulnerability of these infrastructures to attacks may result in unacceptable risks because of primary and cascading effects. The investigation of cascading and feedback effects in highly complex, networked systems requires massive support by computer-based tools. The aim of ACIP is to provide a roadmap for the development and application of modelling and simulation, gaming and further adequate methodologies for identification and evaluation of the state of the art of critical infrastructure protection (CIP); for analysis of mutual dependencies of infrastructures and cascading effects; for investigation of different scenarios in order to determine gaps, deficiencies, and robustness of information infrastructures; and for identification of technological development and necessary protective measures for CIP. Developed societies have become increasingly dependent on ICT and services. Infrastructures such as information and communication, banking and finance, energy, transportation, and others are relying on ICT and are mutually dependent. The vulnerability of these infrastructures to attacks may result in unacceptable risks because of primary and cascading effects. The investigation of cascading and feedback effects in highly complex, networked systems requires massive support by computer-based tools. The aim of ACIP is to provide a roadmap for the development and application of modelling and simulation, gaming and further adequate methodologies for identification and evaluation of the state of the art of critical infrastructure protection (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The Past in its Place: Histories of Memory in England and Wales'.

assistant: **Innovation**

This five-year project will explore the ‘history of memory’ in a range of English and Welsh locales from the early medieval period down to the modern era.  Drawing on the disciplinary perspectives of literary studies and archaeology, the project will identify and interpret textual and material ‘technologies of remembrance’, including texts, oral traditions, monuments and customary practices. PASTPLACE will transcend the boundaries of periodization and discipline to examine patterns of remembrance, re-imagining and forgetting over the longue durée.Research will be organized in three strands with staggered start-dates, focusing on three types of locale strongly associated with cultural and individual memory.  Strand 1 focuses on the history of death, burial and commemoration at a group of English and Welsh cathedrals. Strand 2 explores the interaction of medieval, early modern and modern people with sites of ancient habitation, including Roman settlements, Iron Age hill forts, and prehistoric tombs. Strand 3, ‘Topographies of Memory’, explores the organization of natural and historical landscape features in perceptual frameworks. Research in each strand will centre on six case studies drawn from across southern Britain, with clusterings in the southwest and the Welsh borders.The project’s findings will be disseminated in three co-authored volumes, edited by the PI, under the general title The Past in its Place. Exemplifying a fresh interdisciplinary approach to the history of memory, the project aims to ignite further research both within Britain and overseas. With its cross-period approach, innovative combination of literary and archaeological perspectives and methodologies, and multicultural focus, this timely project addresses challenges at the frontiers of multiple di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Investigating the therapeutic potential of manipulating the IGF-IGFBP1 axis in the prevention and treatment of cardiovascular disease, diabetes and obesity'.

assistant: **Concept**

More than 30 million people are living with diabetes in the EU, with a prevalence expected to grow to over 10% of the adult population by the year 2030. Type 2 diabetes is a major cause of cardiovascular disease related death and disability, substantially increasing the risk of myocardial infarction, stroke and peripheral arterial disease. Recent landmark trials, showing that intensive glucose control does not improve cardiovascular outcomes and may increase mortality in some circumstances, provide a compelling rationale for intense research aimed at developing novel therapeutic strategies. Type 2 diabetes is underpinned by resistance to the effects of insulin, which I have shown in endothelial cells causes reduced bioavailability of the anti-atherosclerotic molecule nitric oxide and leads to accelerated atherosclerosis.  The cellular effects of insulin are mirrored by insulin-like growth factor factor-1, the bioavailability of which at its receptor is in turn is regulated by a family of high affinity binding proteins (IGFBP). Epidemiological studies demonstrate and inverse association between one of these binding proteins, IGFBP1, and diabetes-related cardiovascular risk. I have recently demonstrated that IGFBP1 when expressed in mice can ameliorate insulin resistance, obesity and atherosclerosis. In endothelial cells, I showed that IGFBP1 upregulates the production of nitric oxide indepenedently of IGF. These findings suggest that IGFBP1 may be a ‘protective’ endogenous protein and that increasing circulating levels may be a therapeutic strategy to prevent development of diabetes and cardiovascular disease. In this proposal I will address this hypothesis by employing state of the art studies in cells and novel gene modified mice to unravel the molecular basis of the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Non-Territorial Autonomy as Minority Protection in Europe: An Intellectual and Political History of a Travelling Idea, 1850-2000' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Over the past 150 years, non-territorial autonomy has been one of three models for dealing with linguistic or ethnic minorities within several European states. Compared with the other two, i.e. the recognition of minority rights as individual rights and territorial self-rule, non-territorial autonomy has received little attention. This project proposes to write the first history of non-territorial autonomy as an applied policy tool in minority protection and as an intellectual concept with a chequered history across Europe. Intellectuals, politicians, and legal scholars across the political spectrum from the far left to the far right supported this idea, although they were aware of the risks of strengthening national differences by promoting such a collective approach to minority protection. The project explores how this idea of granting cultural rights to a national group as a corporate body within a state, as a means of integrating diverse nationalities, travelled and transformed throughout the Habsburg Empire from 1850 to the present. We propose to 1) trace the development/circulation of theoretical conceptions and political applications of non-territorial autonomy within the Habsburg Empire, by mapping the networks of scholars as well as politicians who advocated for it; 2) explain the continuities in the development of the idea, and its manifestations in policies adopted by interwar Central and Eastern European nation states, where communists, socialists, liberals and fascists alike were able to translate elements of non-territorial autonomy into their ideologies and programs; 3) analyse the treatment of non-territorial autonomy, which was advocated by minority lobby groups, in international minority protection in the 20th century despite strong opposition to pract
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Adaptive Learning via Intuitive/Interactive, Collaborative and Emotional systems'.

assistant: **Innovation**

Despite a great potential and some initial successes, e-learning systems do not yet have the impact that many believe is possible. Moreover, the gap seems to be increasing because of the greater expectations of the current generation (Digital Natives) who have grown up with modern technology. There are also more general problems. In particular, an over-emphasis on cost effectiveness has meant that content is often not as strong as it needs to be and this deficiency has contributed to a lack of user engagement and some high attrition rates. Studies have consistently highlighted the important relationship between engagement and learning, with students who are highly motivated being more likely to engage in the learning process.ALICE aims at building an innovative adaptive environment for e-learning combining personalization, collaboration and simulation aspects within an affective/emotional based approach able to contribute to the overcoming of the quoted limitations of current e-learning systems and content. In other words the proposed environment will be interactive, challenging and context aware while enabling learners' demand of empowerment, social identity, and authentic learning experience.The defined system will be able to effectively involve learners in educational, cultural and informative activities in two specific contexts: university instruction (with particular emphasis on scientific topics) and training about emergency and civil defence (as for example the behaviour to take at a personal and collective level when the treat of a big risk shows up e.g. a natural event like earthquake, or a fraudulent one like terrorist attack).The ALICE starting point will be an already existing e-Learning platform named IWT developed exploiting experiences and know-how gained
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'BioliSME II – Demonstration, validation and preliminary promotion of a commercial prototype speedy system for sampling and detecting Listeria monocytogenes' under Seventh Framework.

assistant: **Concept**

Listeria mococytogenes is one of the most important food-borne pathogenic bacteria, having “zero tolerance” in ready-to-eat and dairy foods. Currently, a novel system for monitoring the contamination levels in industrial food producing plants in a more fast, safe and efficient manner than current tools is being developed in the framework of the BioliSME project (Project No: 232037). Although the project is still active, the individual components of the final system have been developed beyond the stage of “proof-of-concept”. Therefore, the Project Consortium (comprising 4 SMEs and 3 RTD performes) wishes to launch a follow-up project (BioliSME II) in order to demonstrate, validate and promote (at an exploratory commercial level) the novel assay system for L. mococytogenes.The Project will be implemented in the following Work Packages:WP1 - Subsystem integration to final demonstratorWP2 - Production of several demonstratorsWP3 - Organization and execution of trial testsWP4 - IP protectionWP5 - Validation and disseminationWP6 - Management
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'CONTROL OF SULFUR FLAVOURS IN FOODS' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The main research objectives of this proposal are : - to investigate the metabolism of food-grade microorganisms implicated in the  biosynthesis of sulfur-containing flavour compounds and the metabolic products formed in pure and mixed culture;- to assess the interaction between individual flavourants and other components of multi-phase food matrixes using a range of physico-chemical and sensory analysis techniques;- to validate the results on cheeses or by de novo flavour formulation;- to identify those bacterial strains which are capable of producing the flavours in quantities sufficient for industrial manufacture and finally,- to evaluate the feasibility of biotechnological methods for their production.%To achieve these objectives a significant synthetic effort will also be required because very few sulfur-containing flavour compounds of interest are currently available commercially.The successful implementation of these scientific objectives is a necessary background for the development of technical applications such as :- introduction of screening methodology for sulfur compound producing strains;- control of flavour characteristics of cheeses;- selection of overproducing strains and culture conditions to develop new sources of natural flavours;- establishment of guidelines for the use of the sulfur flavour compounds in  complex flavour formulations.All these developments are required for rational design and introduction of new speciality cheeses, thus offering to the consumer a wider range of high standard foods.Soft cheeses are enjoyed by a large proportion of the adult population in Europe but they have an even greater potential for innovation potential because of the numerous variations they allow for both texture and flavours. To date their consumption is limi