RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reconstructing the imprint of ecology on the genetic phylogeography of the Plague in Central Asia and China' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Yersinia pestis, the causative agent of plague, is a flea-borne disease that caused at least three devastating pandemics in the last two millenia[Stenseth08]. Plague is endemic in wildlife rodents, and the ecological and epidemiological dynamics of the rodent-plague system are the underlying cause of outbreaks in human populations. However, our current understanding of this system is insufficient to mitigate the risk. In this project the researcher will uniquely combine the disciplines of theoretical biology, molecular/evolutionary genetics, epidemiology and ecology to address this important issue.The Centre of Ecological and Evolutionary Synthesis (CEES) in Oslo, Norway has access to unique archives on plague outbreaks in rodents and humans in Central Asia and China. These archives, and the available expertise on the genetic phylogeography of the plague at CEES, provide a great opportunity for the applicant researcher to integrate epidemiological and genetic knowledge of plague with his expertise on dynamic modelling of ecosystems. In return, CEES researchers will benefit from being exposed to these simulation models, and their application in analysing complex ecosystems, as well the contact network of the applicant researcher with modelling groups in the Netherlands and Europe. This project would both significantly strengthen plague research, and would have important corollary impacts on public health and risk assessment.The project will use individual-based models of small rodent ecologies through which plague can spread, and observe the changes in the genetic variance of plague. These changes will be abstracted into a Cellular Automata (CA) [Hogeweg10], a modelling formalism that is suitable for simulating large ecological systems. The ecological and epidemiological
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Windows of microbial activity in deserts afforded by non-rain water' (WinMicAct).

assistant: **Concept**

Soil microorganisms are essential drivers of ecosystem processes in drylands that cover ~40% of the Earth’s landmasses. It is widely accepted that microbial activity in arid deserts is confined to rare, short and unpredictable rain pulses. Yet, water could be available for soil microorganism by other processes, such as dew formation, fog deposition and water vapor adsorption. These so-called non-rain water inputs represent significant sources of water, as they are more frequent and reliable. Yet, it is unknown if desert soil microorganism can utilize these water sources for reactivation, nor the associated microbial activities they facilitate and their overall contribution to microbial-driven ecosystem processes.WinMicAct will challenge the rain-centered view of desert microbial activity. I hypothesize that desert microbial communities can use the minute water input provided by non-rain water for reactivation. WinMicAct pushes the boundaries of molecular omics and microbial activity analysis to detect reactivation down to the lowest possible water availabilities. Utilizing spatial upscaling, WinMicAct will estimate the contribution of these microbial activities (respiration, CO2 and N2 fixation) to the ecosystem level. WinMicAct will further reveal the importance of different water sources for survival and thus maintaining desert soil biodiversity that is crucial for ecosystem functioning. Finally, WinMicAct is highly relevant in light of climate change, as future scenarios predict changing patterns of rain and non-rain water inputs. With the knowledge gained in this project on microbial processes driven by the different water sources under climate change predictions, WinMicAct provides the foundation for future investigations and modeling of climate change effects on d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Research and development of new lanthanide complexes for dying' in the context of a Fourth Framework call.

assistant: **Objectives**

1.1 Objectives: In material from living organisms it is necessary to detect and quantify substances in very low concentrations. The analytical procedures are time consuming an tedious. A system will be developed which allows the detection and measurement of these substances in very low concentrations in a short time. This is of interest for medical and environmental authorities. Actually, most of the sample preparations and measurements are done in one day or overnight. As medical staff needs quick response it is desirable to shorten these procedures. 1.2 Content of the project: The new proposed technic uses capillaries in which the diffusion distance is less than in vials or microtiter plates. The measurement with fluorescent solutions is possible till a concentration of 10e-11 mole /Lin normal glass capillaries. By using the wall of this capillary as guidance for light, fluorescent molecules can be measured at the inner wall side due to the evanescent waves". If the wall is coated with an antigen, then a competitive binding of antibodies is possible. By adding a known amount of fluorescently labelled antibodies and measuring the fluorescence it is possible to calculate the unlabelled amount present. This is called the Multiple Internal Reflexion Assay (MIRA). 1.3 Training content of the proposal: Normal fluorescence will fade away in nanosecond after glow excitation but there are some lanthanides with much longer fluorescent time. Complexes of those are of interest to easily measure these long lasting fluorescence and to improve the sensitivity of these measurements. The development of lanthanide complexes for dying microbeads and for coupling to important biological molecules is a first priority and of absolute necessity. This includes the synthesis of different cryp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Expanding ERA over Russia' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The RUSERA-EXE project is based on the achievements and results of the RUSERA Project (INCO-CT-2004-502262) which was successfully completed on the 30th of April 2004. The objective of RUSERA-EXE is to increase the quantity and quality of cooperation between Russian and EU researchers by creating long lasting researcher-to-researcher RTD partnerships.The project will focus on the 5 most promising and advanced RUSERA FP6 Regional Information Nodes (RINs) (Tomsk, Krasnoyarsk, St.Petersburg, Uljanovsk, Ulan-Ude) who actually will cover the whole territory of the existing RUSERA Network with the assistance of other RUSERA RINs, and achieve its objective by- Establishment of long lasting partnerships between researchers in Russian regions and EU Member States and development and fostering of these contacts via bilateral working visits of Russian and European researchers to Russian and EU host research organisations- Specialized training workshops/seminars for RUSERA RINs, scientists and research managers- Developing new methodology of RTD cooperation between Russia and EU implementation of the new methodology- Creation of handbook for research managers- Inclusion of more partners from Russian regions in projects submitted under FP7 by EU Member States coordinators- Raising awareness in Russian regions about the opportunities of participation in FP7- Promotion of the research potential of Russian regions among the EU Member States scientific community- Improvement of advisory and practical s kills of Russian RINs FP multipliers- Improvement of the skills of potential Russian coordinators to write a successful proposal and to manage it appropriately- Stimulation of the EU scientific community to cooperate with Russian researchers in the regions- Continuous advice to RUSERA RIN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Non-volatile erase-write multi-level silicon integrated circuits'.

assistant: **Objectives**

This project intends to provide an essential contribution with exploratory research on multi-level storage for NV memory applications. It consists of two phases:- The first (12 months) is carried out by three Research Institutes (Universities of Bologna and Pavia in Italy and IMEC in Belgium). Industry, however, will contribute by:-defining essential specifications;-closely following the work;-providing support for test chip realisation.If the first Phase reaches satisfactory results, industry would participate directly in the second Phase Project with a leading role.The first Phase consists essentially of a feasibility study, focused on the most critical issues for the realisation of multi-level NV products and will be split in two parts (6 months each):- study and development of suitable programming and sensing schemes to be implemented on test chips; - experimental characterisation of such test chips.- The second Phase, carried out by a larger consortium that would include a leading company in the field of NV memories, would last 3 years and be explicitly dedicated to the realisation of competitive NV memories based on the results of the first Phase.The most important type of NV components are FLASH memories. From the point of view of multi-level storage, a major problem is that of correctly sensing closely spaced stored charge levels (also affected by imperfect charge retention). This problem is common to all types of NV memories, hence can be studied by means of EPROM cells, simpler to fabricate and providing worst-case conditions for cell sensing because of their limited threshold window.The other major problem concerns cell programming (or writing), required to achieve tight distributions of multiple transistor thresholds. FLASH cell programming can exploit eithe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Novel approaches towards understanding of gene transcription using small molecules as tools'.

assistant: **Objectives**

Small molecule modulators of protein function proved to be effective tools to elucidate the functions of newly identified proteins in reverse chemical genetic studies. In the field of gene transcription regulation many new proteins with a poorly defined function are being discovered. Among these proteins many enzymes are found that modulate acylation and phosphorylation. These posttranslational modifications play an important role in cellular localization and protein-protein interactions of transcription factors. An interesting feature is that acylation competes with other posttranslational modification such as ubiquitinylation, sumoylation, palmitoylation etc. Acetylation can thus be considered a key regulatory event. We propose to develop small molecule inhibitors to study lysine acetyl transferases in a reverse chemical genetics approach. Furthermore, we propose to develop innovative chemical cross-linkers to specifically cross link lysine acetyl transferases and their targets in vivo in order to elucidate the binding partners of these enzymes. Together these small molecules will provide tools to study spatial and temporal control in gene transcription by the Smad transcription factors in fluorescence microscopy studies of cell based systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Action words Learning in a Humanoid Robot by Discovering Tool Affordances via Statistical Inference' (ROBOTASK).

assistant: **Innovation**

Recently, humanoids have started to be employed in linguistic investigations with the dual aim of endowing robots with the capability to communicate and interact with humans, and further understanding the mechanisms underlying language development. The proposed research aims at creating a developmental cognitive model for the iCub humanoid robot for grounding the meaning of language in tool affordances. Despite it is firmly clear that language has to be grounded in sensorimotor experience, recently it has became increasingly evident the importance of going beyond simple sensorimotor grounding. To this end, statistical inference provides an original and innovative methodology that can serve in grounded theories of meaning. Computational modeling, based on statistical inference over hierarchies of flexibly structured representations, can address important problems related to human intelligence and cognition, such as the learning of language and causal relations. This research will permit to endow the iCub robot with the ability to understand language during the interaction with a human tutor and provide an experimental framework for investigating how language interacts with other cognitive processes, such as motor control. Additionally, a human-robot interaction study will permit to analyze how people experience interaction through language with the iCub robot. On the one hand, the proposed artificial cognitive system can progress theories of language learning in robots, with consequent advances in the design of human-robot communication systems, which can lead to a new generation of interactive robots. On the other hand, experiments performed on the model, by generating new predictions, can have important implications in cognitive science. The grant of the fellowship wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Pay inequalities and economic performance' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Do large wage inequalities boost on hinder firms' economic and employment performance?To answer this question we look at two key functions of wage inequalities: allocating labour across labour markets, and as a part of firms' personnel management, training and industrial relations policies.It has long been suspected that the wage differences that would encourage mobility and assist in reducing unemployment conflict with the demands on personnel management to retain and motivate staff within the enterprise, and with those of cooperative workplace relations. But these hypotheses have never been tested simultaneously across a rich cross-section of advanced industrial countries. We shall use the micro-data from the 1995 European Structure of Earnings Survey, combined with other data sources. To facilitate data access our consortium involves eight statistical offices involved in the survey. We shall extend our comparison to Japan and the US.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Investigations on the effect of reactive surfactants on latex film microstructure and properties via tracer diffusion' in the context of a Seventh Framework call.

assistant: **Objectives**

Aqueous film forming polymer (latex) dispersions are widely used in the adhesive and coating industry. In recent years, significant research effort is devoted to the development of reactive surfactants for emulsion polymerization, with the aim of achieving better product performance in these water-based systems. They are devised to produce emulsions with better technical properties like emulsion stability, low water uptake of dry films, and better gloss. The reactive surfactant takes part in the polymerization and becomes a part of the polymer chain, and thus modifies the film formation process, the film microstructure as well as the film properties. So far, however, a clear molecular level understanding of how reactive surfactants influence the performance of coatings is missing. Thus, studies at molecular length scales performed on well-defined model systems, where the particle surfaces are modified with covalently attached surfactants, are important to understand the film formation process and tailoring film properties. In this project a systematic study on the influence of anionic reactive surfactants on latex film formation and film properties of Poly (butyl methacrylate) emulsions, employing a tracer diffusion technique (Forced Rayleigh scattering; FRS) is proposed. Reactive surfactants avoid surfactant migration to and aggregation at the polymer-substrate and the polymer-air interface and also modify the polymer interdiffusion between particles that is necessary to form a mechanically strong film. Both effects can be studied at molecular level with the FRS technique. The benefit of the proposed studies will be an improved understanding of the relationship between the nature of the interfacial membranes (depending upon the surfactant used) and the film formation p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Use of sage to investigate cytotrophoblast gene expression in pre-eclampsia.' (1998-2002).

assistant: **Concept**

This project will use serial analysis of gene expression to produce a quantitative description of gene expression in normal and pre-eclamptic cytotrophoblast in order to identify differential, or disrupted, gene expression which may be associated with the pathogenesis of pre-eclampsia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular analysis of protein degradation associated with the endoplasmic reticulum' (1994-1998).

assistant: **Concept**

Research objectives and content The endoplasmic reticulum (ER) is the most important quality control point in the exocytic pathway followed by newly synthesized secretory proteins. Those proteins that fail to achieve its mature conformation (due to defective folding and/or oligomerization) are selectively retained or degraded in the ER. This ER-associated degradation" (ERAD) has been extensively studied for several proteins, and some functional general properties of the pathway have been described. However, little is known about the protein machinery involved in it. The objective of the project is to analyze at the molecular level this degradative pathway, using as a model protein the light chain of the immunoglobulins. For this purpose our efforts will be directed towards the following studies: (1) To develop an "in vitro" model system for the light chain degradation. Microsomes from different yeast strains and from dog pancreas will be used. The first question will be if cytosol is required or not to the ERAD to occur. (2) To identify and characterize the protein machinery involved in degradation (located in the microsomes or in the cytosol). We are specially interested in the proteases catalyzing directly the degradation. In this sense, the participation of the proteasome in the ERAD will be assessed. Training content (objective, benefit and expected impact) The main objective is to obtain a detailed knowledge at the molecular level of the novel degradative pathway of proteins m the ER. This will have special relevance in three aspects: basic research, health care and biotechnology. Concerning the first, the ERAD may be a constitutive pathway of degradation very important in the control of the level of secretory proteins in the cells, and probably, it is finely regul