RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Quantifying the evolution of Earth's atmosphere with novel isotope systems and modelling', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Atmospheric oxygen is fundamental to life as we know it, but its concentration has changed dramatically over Earth’s 4.5 billion year history.  An amazing qualitative story has emerged, in which Earth’s atmosphere was devoid of free oxygen for the first 2 billion years of planetary history, with two significant increases in concentration at ~2.4 and ~0.55 billion years ago.  Both oxygenation events were accompanied by extreme climatic effects – the “snowball earth” episodes – and paved the way for massive reorganization of biogeochemical cycles such as the Cambrian radiation of macroscopic life. Despite these profound influences on the Earth system, we currently lack fundamental quantitative constraints on Earth’s atmospheric evolution. I am poised to add substantial quantitative rigor to Earth’s atmospheric history, by constraining the concentrations of important gases (e.g., O2, O3, CO2, CH4, organic haze) in ancient atmospheres to unprecedented accuracy. I will accomplish this via an innovative interdisciplinary program focused on the unusual mass-independent isotope fractionations observed in sedimentary rocks containing sulfur and oxygen. These signals are direct remnants of ancient atmospheric chemistry, and contain far more information than can currently be interpreted. This project combines novel experimental and methodological approaches with state-of-the-art numerical modelling to significantly advance our ability to decipher the isotope records. A unique “early Earth” UV lamp coupled to a custom-built photocell will enable direct production of isotope signals under Earth-like conditions, with time-dependent sampling. Groundbreaking analytical methodologies will vastly increase the global geochemical database. The experimental results and data will provide gro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European Surveillance Network for Influenza in Pigs 2', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

This European surveillance network for influenza in pigs (ESNIP) 2" will maintain and expand a surveillance network that was established during a previous EC concerted action (ESNIP 1, QLK2-CT-2000-01636). Three workpackages (WP 1, 2, 3) aim at a better understanding of the epidemiology and evolution of swine influenza virus (SIV) in different European countries, through an organised surveillance programme together with antigenic/genetic characterisation using standardised methodology.These data will be used to improve the diagnosis of SIV by updating the reagents used in classical techniques (WP 4) and by the development of a rapid, molecular test for SIV detection (WP 5). The virus bank and electronic database that were established during ESNIP 1 will also be expanded with relevant SIV isolates and information (WP 6). Beyond this, we will be better able to define the public health risks of influenza in swine. This will be achieved by serological monitoring of swine for avian influenza viruses (WP 7) and by comparison of the influenza viruses that are currently circulating in swine, avian species and humans (WP 8). ESNIP 2 represents the only organised surveillance network for influenza in pigs and the first attempt to establish formal interactions with human and avian surveillance networks. These initiatives and interactions are entirely consistent with improved pandemic preparedness and planning for human influenza.The consortium consists of 11 participants who are actively working with SIV. Eight participants are from 7 different EU member states, five of which have been actively involved in the ESNIP 1 network whilst one participant is from Bulgaria, a candidate member state. Participation from third countries (Hong Kong, USA) will facilitate greater global interac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Separation and purification of biopolymers and biopharmaceuticals using advanced chemical engineering tools' to be submitted under Seventh Framework.

assistant: **Abstract**

Novel advanced tools for robust, low-cost separation and purification of Biopolymers are expected to drive EU improvements in the fields of clinical analysis, proteomics and downstream purification of biopharmaceuticals.  The application of plastic microcapillaries to the separation and purification of biopolymers will offer high accuracy and reliability with significant reductions in instrumentation cost over conventional systems. Platforms to be designed with multiplexed capillaries will significantly enhance productivity in the biopharmaceutical and medical fields and open up new markets for capillary instrumentation. Plastic microcapillaries will be adapted to support separations of biopolymers through affinity and ion-exchange chromatography and capillary electrophoresis. Capillary walls (made of a wide range of thermoplastics) will act as the matrix for immobilisation of affinity ligands or deposition of positive/negative charges. The added values of optical transparency, stability and precise internal diameter of the plastic capillaries will be explored for the purification of biopolymers by electrophoretic methods. The project will be carried out at the University of Cambridge, where very accurate, parallel capillaries have been embedded in a plastic film extruded through a patented process. Prof. Malcolm Mackley, at the department of chemical engineering, was the co-inventor of the new extrusion process and will be in charge of supervising this project. The extrusion process is very cheap, making the plastic films disposable after a single cycle of purifications. Prof. Howard Chase will provide the necessary knowledge in bioseparations for the development of plastic, affinity and ion-exchange capillaries. Lamina Dielectrics Ltd is currently licensed for manufac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Réseau thématique sur emploi, chômage et protection sociale: cohésion sociale au défi de la mondialisation et des ntic""'.

assistant: **Innovation**

The purpose of the project is to build up a thematic network of western and eastern European researchers, together with Chinese researchers. The network will analyse employment policies and social protection policies and the changing patterns of work and employment in the context of globalisation. This analysis will focus on the consequences of this process on social cohesion in Europe and China and will compare the various employment and social policies implemented by European and Chinese governments in order to adapt their economies while maintaining social cohesion. The comparison will allow identifying a number of common principles that are often taken for granted in the implementation of European policies. This will thus contribute to precise the concept of social Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Accessory Genome Accountability in Pseudomonas aeruginosa Persistent Infections'.

assistant: **Concept**

Bacterial survival to antibiotic treatment poses an urgent problem to humanity, causing 25.000 deaths per year in the European Union alone. The inability to fully eradicate pathogens with antibiotics leads to the establishment of persistent infections (PIs). Pseudomonas aeruginosa, an opportunistic pathogen, is found chronically in the airways of 70% of Cystic Fibrosis (CF) patients. In CF, the anomalous production of mucus in the lung promotes the establishment of bacteria, with infections decreasing the life quality and expectancy of patients. The mechanisms by which P. aeruginosa is able to escape treatment and generate PIs within the CF lung have not been fully elucidated. Mostly, the success of P. aeruginosa relies on its adaptability, which derives from its large genome carrying genes for survival in a wide spectrum of environments. Most of these genes are not conserved among strains, composing the accessory genome (AG), which is built up through horizontal gene transfer (HGT). Previous studies have identified components of the AG involved in virulence and resistance, yet the extent of the AG involvement in PIs is unknown. Through AGAPE I seek to elucidate the relevance of the AG in the establishment of PIs in CF lungs. I will do so by studying both the conformation and function of the AG, through novel CRISPR-Cas tools in P. aeruginosa. First, I will determine the identity and quantity of HGT during infection by recording transfer events with a CRISPR-Cas recorder system. Second, I will generate individual and combinatorial knockdowns of every accessory gene through CRISPR interference (CRISPRi), to screen the effects of the repression on fitness during infection. I will follow the infections of the generated strains on lung organoids derived from the correspondi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Drug repurposing in pancreatic ductal adenocarcinoma' to be submitted under Horizon 2020.

assistant: **Abstract**

The main objective of the REPANCAN is to integrate Jelena Grahovac, PhD at the Institute for Oncology and Radiology of Serbia, as a leader of a project that will address an urgent unmet need for new treatment strategy for patients with pancreatic ductal adenocarcinoma (PDAC).  PDAC is one of the most lethal types of cancer in the world, with a 5-year survival rate of less than 5% and an increasing incidence rate. Research on PDAC is limited and progress in patient survival has not been made in the last 40 years. To circumvent the high costs and long development times for new oncological drugs, the REPANCAN project will use the drug repurposing concept and establish a novel use for a class of nischarin (NISCH) receptor agonists. NISCH receptor itself has been shown to be a tumor suppressor in breast cancer and its agonists hold promise for targeting several aspects of the PDAC pathology: cell invasiveness, survival, metabolism, and the microenvironment. To address the acute demand for novel PDAC therapy, the REPANCAN project will integrate the bioinformatic, molecular and cellular research with the retrospective patient study though 3 research objectives: 1) Examination of levels of NISCH in patient tumor samples and in vitro model systems, 2) Establishment of mechanisms by which clinically approved NISCH agonists can limit PDAC growth and 3) Retrospective analysis of effects of NISCH agonist treatment on PDAC progression in patients. To strengthen the competence of Dr Grahovac and use cutting edge technologies in REPANCAN, a secondment at Dr Peter Carmeliet’s laboratory at VIB-KU Leuven is planned. REPANCAN will establish a novel prognostic marker, novel drug target and a ground for repurposing of low-cost drugs proven to be safe in one of the most lethal and understudi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dynamics of volcanoes and their impact on the environment and society' under Seventh Framework.

assistant: **Concept**

Active volcanoes threaten 500 million people and vulnerability is increasing due to population growth, globalisation and increasing environmental stresses. The project will investigate key topics that will provide the understanding to increase societal risk and reduce vulnerability of communities. The project will: investigate how volcanoes work focussing on the nature and dynamics of magma chambers; construct a global database on volcanic hazards and risk; and develop new approaches to assessment of volcanic risk. The magma chamber is the fundamental control on the behaviour of most volcanoes, and so an advance in understanding of their physical nature and behaviour affects almost every other aspect of volcano behaviour and phenomena. Integrated models of the formation and behaviour of magma chambers will be take account of heat transfer, crustal deformation, magma properties, and internal chamber processes. Volcano behaviour will be investigated in terms of magma flows from chambers to the Earth s surface. The models will be informed by and tested against geophysical, geochemical and observational data at selected volcanoes and igneous intrusions characterised by superb datasets. An integrated model of magma chambers will improve interpretations of geophysical data and understanding of hazardous volcanic phenomena, such as debris avalanches, pyroclastic flows and lahars. The project will create a global database on volcanic eruptions, their hazards and key risk factors (such as population density), which will be analysed to provide robust data for hazard and risk assessment at global, regional and local scales. New methods of probabilistic risk assessment will be developed, which combine hard and soft data, take account of uncertainties and integrate information on vu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Regional Innovation Strategy for Mersin Region of Turkey' (RIS-MERSIN).

assistant: **Innovation**

The consortium undertakes to build and develop an organizational infrastructure RIS Mersin for promoting innovation in the region in accordance with the needs of business and priorities of the regional key actors. The Mersin Region is situated at the sou th side of Turkey at the Mediterranean seashore. The population of the region was found around 1,5 million habitants. The region is partly industrialized and generates 2,8 percent of Turkey's GDP. The Region falls under Objective -I classification of t he Commission. The Coordinator, Teknopark AS, is also the coordinator of IRC-Anatolia project, shall provide harmony between Mersin innovation strategies and the objectives and application of IRC-Anatolia. The Greece partner BIC of EPIRUS-Greece, coordin ating the Regional Development Agency will play a crucial role for the development and successful implementation of the project. The Mersin Chamber of Commerce and Industry together with Mersin University and Mersin Tarsus Organized Industry Zone shall p rovide regional data, assure regional consensus and support of key actors in the region. The RIS Mersin will the first regional innovation strategy prepared in Turkey which will be inline with EU based policies and strategies. The success of the project will increase national awareness towards innovation strategies and EU policies within the people of Turkey. All partners of the consortium have the sufficient resources for successful implementation of the project. The total budget for the project is c alculated to be 416,000 Euros for 32 months period. The whole project shall be developed and managed by the Steering Committee formed by the all partners and other key actors of the region. However implementation and the daily management of the project i s the responsibility
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Hydrocarbon and chemical logistics optimization under uncertainty via stochastic optimization' in the context of a Fourth Framework call.

assistant: **Objectives**

The ability to solve large (in terms of the number of decision variables) and stochastic (in terms of parameters whose values cannot be controlled by the decision maker and are uncertain) industrial problems in practice depends on the sophistication of the tools and techniques available. The project will remedy the inadequacies of the tools currently available by developing flexible software for Supply, Transformation and Distribution (STD) logistics scheduling under uncertainty with access to new, more powerful methods capable of solving problems currently considered intractable. Specifically, the project aims to confer the ability to solve vital revenue critical problems for the industrial partners, namely, STD logistics scheduling under uncertainty for the Hydrocarbon and Chemical sector.The project addresses improvements in both quality (better scheduling, lower costs) and efficiency (shorter response times) in STD scheduling through parallel computing algorithm implementations. This will have a direct bearing on the industrial partners' competitiveness world-wide as they face the challenges of deregulation and market globalization; Furthermore, the software developments which result will be of benefit to other industrial end-users beyond the consortium. HPC offers the means to obtain solutions very quickly, which can mean the difference between obtaining a practical solution and one which is too late for industrial purposes or is not the best solution that can be provided. The project will synthesise existing technology in the following domains:high level model generation,automatic uncertain data scenario generation,optimization through recursion to deal with uncertainty and very large-scale problems, andadvanced data structures to benefit from the opportunity to u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '“Diagnosis of Ischemic Heart Disease by means of innovative and highly accurate high frequency QRS electrocardiogram analysis”' in the context of a Horizon 2020 call.

assistant: **Objectives**

Occlusion of the coronary arteries that supply oxygenated blood to the heart muscle is referred to as ischemic heart disease (IHD). IHD is the most common, serious, chronic, life-threatening illness in the developed world. Currently, the most widely used tool for diagnosing IHD is the electrocardiogram (ECG), which records the electrical activity of the cardiac muscle as it generates the stages of the cardiac cycle. Specific changes in the ECG recorded during physical stress protocols are used for the non-invasive detection of IHD. Patients with positive stress test results are usually referred for further investigation. However, the sensitivity of the standard ECG, even during stress tests, is relatively poor, and is generally considered to be between 50% and 70%, and in some studies has been reported to be even lower. That, in other words, means that 30-50% of all IHD patients are not diagnosed correctly by standard stress ECGs. Traditional ECG analysis is performed in the 0.05 – 100Hz frequency range. However, a significant body of evidence accumulated during recent years indicates that higher frequency spectral components of the ECG signal contain valuable information for the detection of IHD. Studies published by Prof. Shimon Abboud, BSP’s chief scientist, and Dr. Amir Beker, BSP’s founder and CEO, have shown that the presence of ischemic pathologies in the heart is highly correlated with specific changes in the high-frequency spectral components of the ECG. BSP has pioneered the clinical implementation of high-frequency ECG and has developed it into a valuable diagnostic application. The company’s proprietary HyperQ™ technology extracts and analyses the high-frequency components of the ECG. BSP has pursued the development of its HyperQ™ technology in two parallel,