RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanism of Type 9 Secretion: an unusual protein transport system involved in pathogenesis and motility', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The recently-discovered Type IX Secretion System (T9SS) is a protein transport pathway that exports proteins across the outer membrane of Gram-negative of the phylum Bacteroidetes. It is an essential pathogenicity determinant in severe periodontal disease and in the major bacterial diseases of farmed fish. It is also required for the unique Bacteroidete gliding motility. The components required to catalyse T9SS export are still not fully defined, but include at least 18 authenticated proteins. Possible functions can currently only be assigned to some of these T9SS components. However, it is clear that the pathway involves a number of interacting protein complexes.     Our current understanding of the T9SS is superficial and lacking in molecular level structural and mechanistic detail. In a landmark recent study we have identified and structurally characterized the multi-protein outer membrane protein conducting channel of the T9SS. Our ambitious goal is to apply similar state-of-the-art experimental methods to systematically characterise the full T9SS pathway.  We will systematically characterise the component protein complexes that make up the T9SS by:-  Defining their composition through co-purification from native sources.-  Determining their molecular structures by cryo-EM.-  Assessing their dynamic interactions through live cell fluorescence imaging, biochemical experiments, and structural characterization.  In addition, we will use single molecule tracking methods to follow substrate molecules through the steps of the T9SS transport cycle in real time in live bacterial cells and apply this methodology to elucidate T9SS mechanism.


**Keywords:** bacterial protein transport, gliding motility, molecular motor, cryoEM, live cell single molecule fluorescence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Environmental management reform for sustainable farming, fisheries and aquaculture' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The aim of this proposal is to co-ordinate research on environmental management reform to improve sustainability in the farming, fisheries and aquaculture industries. By decreasing pollution and the nuisance value of wastes, and by promoting more efficient waste handling, production, waste recycling, and lower input systems, in line with best management practices, the objectives of the ETAP will be achieved. It is aimed at T5.4.6.2 of area 5.4.6 of thematic priority 5. The specific objectives of this CA are to: - Assemble the latest relevant information on environmental management in the farming, fisheries and aquaculture industries, and to identify key players in the European Research Area, and in INCO countries, to prepare for future projects - Document the current state-of-the-art, and to acquaint members, and the research community in Europe and in INCO countries, with the latest developments in environmental management research - Map current research activities - Identify barriers which prevent effective environmental management and sustainability - Survey national/European legislation and policies - Develop a set of guidelines and recommendations of best practice to help to decrease the environmental impact of the farming, fisheries and aquaculture industries. To aid the implementation of this with implementation workshops - Provide an on-line European database, linked to existing web sites and databases of specialist groups - Promote exchange of European researchers - Promote collaboration with the farming, fisheries and aquaculture industries - Make recommendations for future research - Disseminate knowledge via the specialised web site, technology transfer workshops and the staff exchange programme The main outputs will lead to: - Synergy in research to reform
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'BUILDING A SUSTAINABLE EUROPEAN INNOVATION PLATFORM TO ENHANCE THE REPURPOSING OF MEDICINES FOR ALL' in the context of a Horizon Europe call.

assistant: **Objectives**

REMEDi4ALL aims to establish Europe's leadership globally in the repurposing of medicines by creating a vibrant community of practice covering all relevant sectors and disciplines. REMEDi4ALL will establish and operate a permanent European research and innovation platform comprising the complete value chain for cutting edge, patient-focused repurposing, collaborating with users to execute high potential projects at any phase of development, upskilling all  stakeholder groups through a comprehensive education and training portfolio, and advancing cross-sectoral policy dialogue with all relevant stakeholders and thought leaders. The tools and processes developed assembled in REMEDi4ALL will be validated in a portfolio of 4 ambitious preclinical and clinical phase demonstrators, representing high patient need in a variety of disease areas, including oncology, rare and infectious diseases.The REMEDi4ALL platform will operate a complete, harmonised and accessible value chain integrating the scientific, methodological, financial, legal, regulatory, and intellectual property aspects of the repurposing approach in a goal-oriented and patient-centric approach. Working closely together with research funders and the patient community, REMEDi4ALL will engage and support a substantial user base and concomitant investments through a permanently sustainable entity, working closely with the permanent European Infrastructures and partners. The community of practice comprises leading academic and clinical facilities and infrastructures, medicines regulators, health technology assessors, public agencies and funders, small and large industry, state-of-the-art artificial intelligence and in silico tools, and a global network of collaborators for optimal knowledge exchange.  REMEDi4ALL will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Uncovering immunoediting strategies underlying malignant transformation in breast tissues' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Breast cancer is the leading cause of cancer-related death in women worldwide.  Despite intense research that has led to improved clinical outcomes, a significant number of patients treated with standard therapies suffer from high toxicity and remain unresponsive. In parallel, Immune-Checkpoint Inhibitors (ICI) have transformed cancer treatment by unleashing patients' immune system to combat cancer cells through immunoediting, a natural evolutionary process of removal of antigenic tumor clones. However, application of ICIs for breast cancer remains a challenge as we currently have limited knowledge of the immunoediting strategies and the mechanisms of immune evasion occurring in healthy and malignant tissues. We hypothesize that immunoediting shapes genetic heterogeneity and immunogenicity in healthy mammary cells, driving malignant transformation and response to clinical interventions. To test our hypothesis, we will investigate the mechanisms and influence of immune selection in mammary cells by exploiting novel genomic technologies, providing critical insight into the interplay between the immune system and breast cancer initiation. Our research project will focus on (1) exploring immune selection in healthy and premalignant breast tissues, (2) characterising immune cell populations and their spatial distribution, and (3) determining which interactions prevail during tumour progression. To achieve these goals, we will employ a combination of advanced molecular and high-throughput technologies, including laser microdissection, whole exome sequencing, RNA sequencing, and spatial transcriptomics.Our research has the potential to significantly advance our understanding of breast cancer occurrence and spread, ultimately leading to the development of novel prevention strat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Parallel Donor and Acceptor Semiconductor Crystals for Organic Field Effect Transistors' to be submitted under Horizon 2020.

assistant: **Abstract**

Organic field-effect transistors (0FETs) are essential building blocks for the next generation of cheap and flexible organic circuits. Complementary logic composed of both p- and n-type OFETs with high mobility are absolutely needed to fabricate performing electronic circuits. Generally, single crystals of small molecules of organic semiconductors (OSC) exhibit higher charge carrier mobility than polycrystalline films because of the absence of grain boundaries. Unfortunately, the growth of single crystals from solution or vapor involves little or poor control of orientation, size and shape of single crystals. To solve this problem, PARADA proposes a radically new approach that relies on directional crystallization as a tool to grow parallel single crystal stripes of p- and n- type molecular semiconductors from eutectic mixtures to fabricate single crystal transistorswhich are able to operate in complementary logic mode. Eutectic mixtures will be composed of derivatives of benzothienobenzothiophene (BTBT) and derivatives of carboxydiimides (NTCDI) that are among the best performing p- and n-type semiconductors, respectively. A large set of crystallization conditions will be used to control the pattern and themorphology of thin films. Full structural and morphological characterization will be carry out by XRD, POM and AFM. Thin films with parallel crystalline stripes will be used to fabricate p- and n-type OFETs. The values of electron mobility in the n-type semiconductor and hole mobility in the p-type semiconductor will be extracted from devices. They are anticipated to exceed 5 cm2/V.s. The device work will be completed by basic electrical circuit to demonstrate complementary logic. PARADA combines fundamental and applied research and integrates a broad range a researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of antibiofilm coatings for implants' (COATIM).

assistant: **Concept**

The aim of the SME-driven COATIM consortium is to tackle the increasing problem of infections due to biofilms, groups of microorganisms that stick together on different surfaces within the human body and escape conventional antibiotic treatment. Biofilms are typically found on medical devices like implants. The most recent generation of implants with open porosity enable fast osseointegration, but also present an increased risk of microbial biofilm-associated infection. Biofilm-associated infections are responsible for 15-25% of implant failure, and necessitate burdensome and costly revision surgery. The latter is estimated to represent a supplementary medical cost of €800m/year in Europe without taking into account the pain and distress of the patients, indicating that any significant reduction of this type of implant failure is highly recommended. Until now, biocidal implant coatings have been developed that are based on either the release of silver ions, which are toxic upon accumulation, or on conventional antibiotics that have poor activity against microorganisms in biofilms. Therefore, COATIM aims to develop the next generation of implant coatings containing novel potent proprietary antibiofilm molecules (ABMs) with inhibitory activity against microbial biofilms. In COATIM, these ABMs are grafted or deposited on small titanium implant substrates, as a model for dental and orthopaedic implants. Next, the ABM-coated implants are evaluated for in vitro and in vivo activity in resisting microbial infection without compromising osseointegration. Finally, the ABM-coating is applied on complex orthopaedic and dental implants, allowing the exploitation of the results by industry. In parallel, the antibiofilm mode of action of the ABMs is unraveled. COATIM contributes to a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multi-dimensional Intervention Support Architecture for Gamified eHealth and mHealth Products' under Horizon 2020.

assistant: **Concept**

This project investigates evidence based gamification techniques for eHealth and mHealth and develops a multi-dimensional intervention support architecture/platform in order to improve the efficacy of gamified eHealth products (web-based health tools and health apps). The project will develop advanced game production techniques with ready-to-use toolkits to accelerate the innovation process for eHealth and mHealth products. This will help digital industry (games, IoT and ICT) to innovate new products and services with science and technology underpinnings.It addresses fundamental issues of gamification for eHealth interventions including its development process and evaluation methods for measuring its efficacy. The outcomes of the project, manifested as gamification Toolkits, an integrated ICT Platform, and clinical assessment Methodologies as whole as a framework, will greatly accelerate the pace and scale of eHealth innovation by transforming and increasing its quality and efficiency through advanced technology tools, frameworks and methodologies. By using gamified physical activity engagement as a clinical intervention case study, the proposed framework will be evaluated and tested within patients in primary care settings, who are identified as physical inactive and at risk for their conditions due to sedentary behaviours. However, the gamification framework remains flexible and portable to other contexts of digital health interventions.The project presents two key innovation components:•An innovative collaborative R&D programme in collaboration with industry, focus on delivering solutions to address challenges in the development process of gamified eHealth products i.e. productivity and efficacy.•A strong and sustainable model of collaboration with digital industry a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The development of a low cost, easy to use toolkit providing food processing SMEs with the ability to both forward and backward trace, and to rectify process-centric applications' in the context of a Sixth Framework call.

assistant: **Objectives**

Our proposed development will deliver a toolkit that can be used by SME food processors to model their process at an appropriate level of abstraction (using our proposed tool ProcMod), capture process and ingredient characteristics in real time (within our proposed unified storage architecture UniArc), forward and backward trace to determine either the resultant end product from ingredients or process settings, or ingredients and process settings implicated in end product production (using our proposed multi-platform tool Tracer) and to probabilistically determine the point of failure and most appropriate rectification paradigm (through our novel intelligent decision support network Solver).The results of our development will be used by food processing companies, represented in the EU by 310,000 organisations, in order for them to begin the process of supporting rapid and cost-effective product traceability. The main benefit to those organisations adopting our technology will be a significant reduction in time taken, and a significant increase in accuracy of product traceability across their production process, resulting in:Compliance with current and pending legislationBeing able to take prompt action to remove products from sale and protect brand reputationMinimization of the size of any withdrawal and hence the costs incurred in recovering, disposing or reconditioning products already placed in the marketDiagnosing and solving problems process-centricAssurance of end-product place of origin and qualityIncreased visibility of the production process and stock control, resulting in increased production and stock handling efficiency
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reconfiguring Research and Innovation Constellations' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The RiConfigure project will enable the diversification of constellations, institutions and actors in research and innovation (R&I) by engaging stakeholders, enhancing conceptual clarity on new constellations, and disseminating best practices to practitioners and policy-makers. The project centers on stakeholder engagement in four social labs. In the social labs, actors from  research, industry, the public sector, and civil society will explore how each of them can and do initiate and navigate cross-sectoral collaboration in R&I. Explorations in the labs are complimented by 100+ empirical case studies. On this empirical basis, the project produces a ‘quadruple helix’-framework to provide conceptual clarification on new constellations in R&I.  Expanding the circle of engagement to ensure stakeholder relevance, practitioners and policy-makers can provide challenges and inquiries to the project’s explorations through dedicated dialogue events. The project enables the spread of good practices by facilitating dissemination throughout practitioners’ and policy-makers’ networks, and by providing training to key stakeholders. The project will reach audiences in all relevant sectors through targeted communication and help actors to initiate and support new constellations in R&I by providing inspiration and guidance in the form of handbooks, infotainment videos, on- and offline training, policy briefs, and evidence-based analyses.The project enables the change of R&I governance frameworks at multiple levels by providing evidence on how such frameworks may hinder or help new R&I constellations and by providing dialogue- and learning-opportunities to policy-makers. Initiated by a consortium of actors from all relevant sectors, the project will speak to crosscutting issues with cred
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Seismological investigations of the source characteristics of deep earthquakes' under Fourth Framework.

assistant: **Concept**

Though deep earthquakes were first discovered by Turner at Oxford in 1922, their source characteristics still remains poorly understood. The goal of this project is to obtain better physical insight into the source mechanics of deep earthquakes by a systematic analysis of all available digitally-recorded teleseismic data at depths ranging from crustal to the deepest ones (about 680 km). The spectrum of groups of earthquakes at different depths, having the same size, fault mechanism and duration, will be computed and their spectral characteristics will be compared to obtain any systematic behaviour with depth. Effect of the structure is minimized by the method of choice of events. Finally the seismic moment tensor and the source time function for deep and shallow earthquake groups will be extracted, using a waveform inversion technique partially developed by the applicant. Presence of non-double couple components, if any, will be investigated for the deep earthquakes.