RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Non-linear optical response from first Principles', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The materials with strong nonlinear optical (NLO) response are nowadays widely used in many essential devices of telecommunication and information technology. So far the new NLO materials have been usually discovered via tedious and expensive process of trial and error. Deeper molecular level understanding of various effects and processes responsible for making a good material can lead to major technological progress. It was not until recently that such issues could be addressed by computational approach. Developments in computer technology and in plain wave density functional theory (CASTEP package), have made it possible to predict NLO properties of crystals with reliable accuracy. It has led to better understanding of optical and mechanical properties of many popular NLO materials. On the other hand the NLO spectroscopy methods are frequently used in basic and applied research for their rich information content about electronically and vibrationally excited states and dynamics in molecular systems. In the host department the NLO methods like pump-probe spectroscopy and photon echo are used to study ultra fast processes in many different systems: light harvesting pigment protein complexes, conjugated polymers, supramolecular complexes for artificial photosynthesis etc. In complex systems it is often a major challenge to disentangle the experimental NLO observables in terms of elementary molecular level processes. We use quantum chemistry calculations and computer modelling to better understand what the experimental data means. The aim of the research project is to combine the experience obtained in the research of NLO materials and the NLO methods. The common ground of the two approaches is a nonlinear optical response of a molecular system. In the framework of the pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Cytochromes p450 as drug targets against mycobacterium tuberculosis and mycobacterium leprae.'.

assistant: **Concept**

Mycobacterium tuberculosis (Mtb) is the biggest killer among infectious diseases. Multi-drug resistant strains are widespread. New antibiotic strategies are desperately needed to combat the deadly pathogen. The genome sequence of Mtb revealed that Mtb encodes a high number (~20) of cytochromes P450 (P450s). These enzymes have roles in sterol, lipid and and polyketide metabolism in the cell. The recent determination of the genome sequence of the leprosy pathogen (M. leprae) indicates a much smaller number of proteins encoded, with only a single P450 remaining. The remaining P450 is likely to be essential for bacterial viability. Azole drugs which inhibit activity of P450 enzymes also exhibit potent anti-mycobacterial effects. This suggests that azoles may be useful new drugs against these deadly pathogens. The major objectives of this proposal are the systematic study of the sole M. leprae P450 and its homologue in M. tuberculosis. This will involve protein expression and purification of the P450s, and detailed kinetic, spectroscopic and structural analysis of these enzymes. The substrate selectivity will be determined by spectral titrations and lipid analysis, and activity will be reconstituted with expressed redox partners. Azoles interactions will be also be examined. Collectively, these studies will allow fundamental understanding of these P450s' properties and their potential as drug targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Decision making: from neurochemical mechanisms to network dynamics to behaviour', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

How we decide between different alternatives is a central question to cognitive neuroscience. Decisions may appear trivial (selecting between two meals), or sophisticated and long reaching (deciding whom to marry). Decisions constitute a highly dynamical process of evidence accumulation. These dynamics can be represented in cortical oscillations, which have attracted great interest as a key mechanism that coordinates fast computations. While a few studies have investigated the role of cortical oscillations in decision making, the underlying mechanisms translating neurochemical activity into network dynamics and ultimately into choice remain unknown. Although neuromodulator effects are well described at the cellular level, their network effects during high-level behaviours are not well understood. There is however evidence that neuromodulators also control cortical oscillations and that this may have behavioural relevance. For a mechanistic understanding of human decision making, it is essential to (1) study its fast temporal cortical dynamics and (2) understand how neurochemical signalling gives rise to network dynamics and ultimately to cognition. Biophysical network models are excellent tools for linking these different levels of investigation. Such an understanding is critically important not only from a basic science perspective, it will also further our understanding of psychiatric diseases, which are often characterized by anomalies in neurochemical systems, neural oscillations and decision making.The novel approach that is core to this proposal is to investigate whether and how neurochemical systems guide decision behaviour by modulating cortical dynamics. To achieve this ambitious goal, I will use a combination of imaging methods with computational modelling, ph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New tools for key questions in plant development: using qualitative and quantitative proteomics for direct determination of the set of DNA and RNA-binding factors regulating single copy genes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Plant development is based on the activity of meristems. The aerial part of plants is generated from the activity of the shoot apical meristem (SAM). These meristems determine the plant architecture and correct plant architecture have an immense impact in crop productivity. In the plant model Arabidopsis thaliana, a key gene for the correct functioning of the SAM is SHOOT MERISTEMLESS (STM). To study the function of this gene and to apply this knowledge to control plant architecture to generate valuable new plant varieties is of vital importance to determine how this gene is regulated throughout development. Gene regulation is controlled mainly by the action of transcription factors at transcriptional level and also by RNA-binding factors at post-transcriptional level. Then the goal of the project is to determine the set of transcription factors and RNA-binding factors that regulate STM throughout plant development. Current techniques for the determination of the set of factors regulating a gene give partial results, are time-consuming and require huge amounts of biological samples. Then, new tools have to be developed. The most promising ones involve the use of quantitative Proteomics with the latest advances of high-resolution Mass Spectrometry. We take advantage in the recognized expertise in this field of Proteomics by the host institution to develop these new techniques and put them available for the research community. In particular, the results and new discoveries obtained from this project are intended to represent a great progress in plant research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Modulation of neuronal Signaling by Brain Extracellular Space Structure and Dynamics' (NeuroExcell), addressing dissemination and exploitation.

assistant: **Impact**

NeuroExcell aims to reveal physiological roles of the ECS structure and dynamics in directly regulating neuronal signalling, by taking advantage of the innovative new Super-resolution Shadow Imaging (SUSHI) technique. It will elucidate the nanoscale structure of the ECS of entire mouse brain hemispheres at different planes of the brain. Inherently, it will reveal simultaneously all cells as analyzable shadows what will provide unprecedented ECS maps, to complement general existing cellular maps. The results will further clarify the distribution and duration of structural ECS dynamics across areas, and will disclose the relation between ECS structure, dynamics and protein distribution in the extracellular matrix. Investigating this in live tissue slices will further allow direct visualization and analysis of diffusional processes what will help to disclose the physiological roles of the ECS.The fundamental nature of the results, and the advanced technological framework, will be of fundamental interest for neurophysiologists, glia cell biologists, and glymphatic system researchers, among others. NeuroExcell will be carried out in a multidisciplinary environment involving advanced fluorescence imaging methods, classic electrophysiological techniques, computational modelling, biophysical theory and biochemistry. For the project I will join an emerging neuroscience institute where I will further enhance and diversify my professional competences through advanced training and quality research, adding to my development toward becoming an independent research group leader.


**Keywords:** Brain extracellular space ,   neuronal signaling ,  extrasynaptic signaling,  microglia ,  STED ,  super-resolution ,  Optogenetics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'European research network on foundations, software infrastructures and applications for large scale distributed, grid and peer-to-peer technologies'.

assistant: **Innovation**

CoreGRID aims at strengthening and advancing scientific and technological excellence in the area of Grid and P2P technologies. To achieve this objective, the Network brings together 119 permanent researchers and 165 PhD students from 42 institutions.An ambitious joint programme of activity will be conducted around 6 complementary research areas that have been selected on the basis of their strategic importance, their research challenges and the recognised European expertise to develop next generation Grid middleware, namely: knowledge & data management; programming models; system architecture; Grid information and monitoring services; resource management and scheduling; problem solving environments, tools and GRID systems.To ensure durable integration, the Network is operated as a European Research Laboratory having 6 institutes mapped to the areas identified in the joint programme of activity. It is funded by a European grant assigned to CoreGRID, for a duration of 4 years, to cover the integration costs while the network partners cover the expense required to perform the research associated with the joint programme of activities. Integration is achieved by the joint execution of research projects, the sharing of a common grid testbed for research assessment, the access to a common communication infrastructure to ensure collaboration and dissemination, and a coherent management framework to encourage mobility of researchers, post-doctoral and PhD students.To guarantee that the expertise and the knowledge gained by Network participants will be of mutual benefit to the European Grid community, CoreGRID will organise a set of activities to spread excellence outside the Network such as a public web site, publications, thematic workshops, conferences and training activities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New means to promote pedestrian traffic in cities' (PROMPT).

assistant: **Innovation**

Problems to be solvedProblems related to traffic, congestion, parking, traffic safety, noise and pollution, and to physical, functional and qualitative decay of our urban environment in general, are today particularly acute in European cities. Since the 1950's the trend has been in all European cities to become more and more car-oriented. Car traffic increasingly occupies public spaces of the cities and causes pollution, noise and casualties. This has happened despite many efforts to regulate it in cities. At the same time the share of the non-motorised transport modes is declining all over Europe, although bicycling in some European cities plays an important role. Several European policies bring forward the problems concerning quality of life, equality, parity of access to basic services, social inclusion, regeneration of urban areas, sustainability of the urban environment, pollution, and condition of buildings, public spaces, cultural heritage and the balance of the urban system. The increase of the use of cars in our cities is one significant cause for all these problems. A revival of walking in cities would be a simple and natural way to remedy many of the above-mentioned problems. It would reduce the use of cars and enhance the use of public transport and thus decrease the pollution load. It would also promote the social life in the public spaces and improve the parity of citizens. The promotion of walking would also have many other positive consequences by, for example, improving citizens' physical condition and opening again their eyes to the details and richness of the surrounding nature and physical milieu. However, the problem remains how to effectively promote city walking.Scientific objectives and approachThe main goal of PROMPT is to promote walking in cit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European Clean Aviation Regional Ecosystems' (ECARE) under Horizon Europe.

assistant: **Objectives**

To reach Europe climate neutrality by 2050 as ambitioned by the Green Deal strategy, it is necessary to drastically reduce emissions from aviation. Clean Aviation Joint Undertaking has set out a very ambitious innovation programme to achieve this goal but it is also necessary to create synergy with the different aeronautical regional/national funding programmes in order to create leverage effects and maximise funding impact.ECARE project’s objective is to draw linkage between European/national/regional roadmaps and aeronautical stakeholders and co-create synergies through a pilot covering 4 major aeronautical European regions (Occitanie and Nouvelle Aquitaine in France, Hamburg Land in Germany and Campania in Italy) with the aim of creating a methodology expandable to other aeronautical European regions. ECARE digital platform will provide (i) a mapping of funding opportunities, relevant projects, scientific and industrial resources, (ii) a forum for exchange of information. The ECARE Stakeholders Group (funding bodies, clusters and other aeronautical stakeholders) will foster and spread ECARE methodology. After more than a hundred interviews with aviation players, national and transnational workshops will co-elaborate and provide recommendations for CAJU Phase 2 implementation by 2025.The consortium is composed of 3 major European aeronautical clusters (Aerospace Valley, Hamburg Aviation and Campania Aerospace District) and one Belgian SME specialized in aeronautics technology services (EASN-TIS). All are experts in their domain and other European aeronautical clusters will be involved inter alia via the EACP (European Aeronautical Clusters Partnership) partnership coordinated by Hamburg Aviation cluster. Eventually the project is expected to bring together more than 3
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Precise brain oxygen monitoring for high-risk preterm infants' in the context of a Horizon 2020 call.

assistant: **Objectives**

Globally, 15 million preterm babies are born annually (435,000 in Europe), from which 1 million die. Even when surviving, they may face disabilities, such as neurodevelopment impairment or paralysis. Since their respiratory and cardiovascular systems are immature, they need early oxygen (O2) therapy. Tissue oximeters are medical devices needed to monitor the actual level of O2 supply in their brain, since little O2 variations can produce irreversible damage. However, current devices are adapted from tissue oximeters initially meant for adults, lacking the precision and reliability preterm babies need. World leading neonatologists have been alerting about the urgent need to develop tissue oximeters specifically designed for preterms, to decrease unnecessary deaths and chronic disabilities.  OxyPrem is our answer: a brain oximeter created just for preterm babies and providing the degree of precision and reliability they need. OxyPrem consists of (1) a high-quality Near-Infrared Spectroscopy (NIRS) sensor embedded in biocompatible silicone that is fixed to the preterm's head to monitor brain O2-levels, and a (2) monitor running advanced analysis algorithms transforming the signals into tissue oxygenation saturation measurements. OxyPrem prototypes have shown unmet levels of precision in clinical studies, reducing 5x the variation observed with competitors. Furthermore, our reusable sensor (opposed to the disposable ones from competitors), translates into important savings. OxyPrem represents a compelling business opportunity, capitalizing from the global neonatal intensive care market, worth €5.6 billion and expected to grow at a CAGR2017-2024 of 5.62%. The commercialization of OxyPrem is key to the viability of our company OxyPrem AG, a Swiss spin-off from University of Z
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Heterogeneous charge-transfer studied by ab initio quantum chemical methods: Application to processes at electrodes and scanning tunnelling images'.

assistant: **Concept**

Electron transfer (ET) is no doubt the essential ingredient of all electrochemical processes and of the related technological applications, fuel cells among them. ET is also at the heart of scanning tunnelling microscopy (STM). Nowadays STM provides one of the few instruments permitting one to handle matter at the nanoscopic scale. Recently, the group at the host institution has shown that it is possible to approach ET at an electrode from a pure ab initio viewpoint and with explicit inclusion of the external electric field. The main goal of the present project is precisely to continue this exciting research field thus contributing to build up new and more accurate models of heterogeneous ET reactions. The ET model developed by the host institution and already applied to the oxidation of halides at a metal anode will be extended to the study of other systems in electrochemical environment involving simultaneously and explicitly uniform and non uniform electric field and solvent effects. A new and original point will concern the application of the present ab initio ET model to the prediction of STM images. The result will be a completely new ab initio approach to STM including explicitly the external bias voltage and taking into account the chemical nature of surface and tip simultaneously. It is expected that the development of the research project outlined above will have consequences for several scientific fields but also will result in a tremendous gain of expertise by the applicant. The applicant with a strong background in theoretical photochemistry and in the application of ab initio methods to the study of mechanistic organic photochemistry will build up considerably on her experience of quantum chemistry by extending her knowledge to the field of solid state phy