RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Denitrification of Water using Electrochemical Biofilms' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

SUMMARY From the standpoint of the conservation of environment and water resource, nitrogen removal from wastewater and nitrate polluted ground water is one of the most important problems in the European Community. The pollution is an environmental problem as well as a health hazard because of the use of groundwater and river water for drinking water production. Biological treatment is the most common method of nitrate removal from wastewater using an anoxic filter after conventional biological treatment or an anoxic stage in activated sludge treatment. The major disadvantages of such systems are that the microorganisms are difficult to maintain, it is a slow and often incomplete process, and an external carbon source is required. Autotrophic microorganisms are known to reduce nitrate to nitrogen while oxidising hydrogen gas. Studies have been carried out using these microorganisms and providing an external stream of hydrogen gas. Although promising, this method has been shown to be slow and have problems of incomplete denitrification. It is possible to attach autotrophic microorganisms as a biofilm to an electrode surface and the hydrogen produced by the electrolysis of water is used for the reduction of nitrate to nitrogen gas. In theory, this would be a more rapid and efficient nitrate removal method than any other to date. Small scale studies on bio-electrochemical denitrification carried out in Japan and US show intitial promise. This study is to assess the possibility of using such an autotrophic biofilm attached to an electrode for the reduction of nitrate and to assess the extent of reduction, practicalities of the method and economics involved. If the project is successful it is envisaged to develop a bioreactor for use in wastewater and drinking water treatmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Functional analysis of evolutionarily conserved mechanisms of ageing on advanced proteome analysis'.

assistant: **Objectives**

The aim of the proposal is to gain novel insight into molecular mechanisms of healthy ageing. Based on a proteomic analysis of ageing processes in a variety of ageing models including model organisms and model systems (e.g. human cell cultures), we will ad dress the question how (1) changes in protein concentration and protein modification, (2) protein-protein interactions and protein networks, (3) signaling mediated by extracellular proteins, and (4) protein turnover and degradation via the proteasomal syst em play a functional role in the ageing process. To this aim we have assembled a consortium of 15 highly experienced European research laboratories, one Chinese high technology Institute and 3 SME's with complementary expertise in the fields of cellular an d molecular biology of ageing, proteomics analysis and MS, structural biology and bioinformatics. By using a centralized cutting-edge proteomic technological platform available in two world-class centres that form part of this consortium and a new platform for cell culture at physiological low oxygen pressure, a high resolution proteomic analysis of unmatched precision will be applied to well-established in vitro models of replicative and stress-induced senescence and cells and tissues from people of differ ent age including centenarians. Novel technology will also allow identification of age-associated post-translational modifications and cleavage events that are known to influence greatly the activity of proteins. Trans-species comparisons will reveal cand idates for proteins that play a functional role in driving ageing processes, allowing for the first time a delineation of cause-effect relationships (instead of mere correlations) governing proteome changes that lead to age-associated phenotypes. The work desc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Stimuli-responsive Membranes for consumer goods sustainability', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

SMARTMEM is a multidisciplinary project leveraging the emerging technology platforms around so-called smart membranes and evolving this platform to commercial use in consumer good products. The objective of this project is the training of 5 PhD students in various scientific fields around membrane technology, involving disciplines from advanced materials synthesis, to membrane production, linking product application and product performance driving new consumer value. The training will be setup in a multi sector way for the students to learn the technical depth of the disciplines as well as the innovation cycle from idea to market application and commercialisation. The objective of the project will be achieved through finding applicability in established markets like textiles with functional benefits, air care devices with health benefits and innovate beyond like develop improved microcapsules which release on demand and improved single dose detergent products, among others. Therefore, SMARTMEM will contribute to accomplish the goals of Europe 2020 strategy through: - training of highly skilful scientists in emerging fields such as stimuli-responsive materials - placing Europe at the vanguard of innovation in sustainable consumer goods by smart controlled release
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Integrated solar air-conditioning system', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Although the fast development of thermal solar systems in the last years has been limited to the production of heat, their use for production of cold is also technically possible, as has been proved by many large scale installations. This solution is characterized by an noticeable synchronization between offer and demand, especially in south Europe, and by more intense exploitation of solar potential. Research and development of an Integrated Solar Air-conditioning System is proposed, the operation of which will be based on the use of thermal solar energy. Main target of the proposed project is the adaptation and optimization of basic energy technologies (high efficiency solar collectors, adsorption cooling machines, devices for automatic control and optimal energy management), aiming to their introduction in an integrated system, specially designed to operate with solar energy and ready for installation. The proposed work will enable SMEs specialized in the area of solar and cooling technologies, to resolve R&D problems related to the design of this type of system, especially in the range of small and medium capacity conditioning devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Innovative on-line process control for recycling of multi-layer scrap plastics'.

assistant: **Innovation**

In Europe the consumption of plastics is predicted to grow by 12 million tons between 1995 and 2006 which represents an annual growth rate of approximately 4%. The recycling of scrap plastic is a priority in the European industry, with an important economic and environmental impact. The imbalance between the waste collectable and the potential end-markets for the recycled plastics and the presence of large quantities of mixed plastic waste where the difficulties and energy consumed in separating into homogeneous fractions and cleaning outweigh the environmental gain of recycling, are the two major constraints. To overcome these problems, addressing particularly multi-layer scrap plastics, an innovative approach was envisaged. The novel idea is to continuously monitor a physical property of the scrap material being incorporated and, through that motoring, automatically determine the proportion of the different components of the scrap. Appropriate flows of single raw components will be introduced into the process through an input signal to the components feed-tanks in order to ensure the specified characteristics of the product being manufactured.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Characterization of Organic Reduced Nitrogen species' to be submitted under Seventh Framework.

assistant: **Abstract**

The proposed Marie Curie Action CORN seeks to aid to the technical adaptation of online Proton Transfer Reaction Mass Spectrometry (PTR-MS) to measure ambient concentrations and fluxes of ammonia (NH3) and selected biogenic reduced volatile organic nitrogenous compounds (amines). The technological development is based on operating the PTR-MS instrument in a new mode, allowing for analysis with significantly improved sensitivity. The capability of an instrument to measure both ammonia and amines at high sensitivity and time resolution would be unique. Taking advantage of the derived high time resolution, the setup will be used for characterizing the exchange pattern of reduced nitrogen compounds over agricultural grassland ecosystems applying a micrometeorological flux approach (Eddy Covariance).   Despite the prominent role of reduced nitrogen species in the environment and respective ecological problems related to the N-cycle, large uncertainties remain both in its exchange processes and related atmospheric chemistry and physics. A large fraction of reduced nitrogen occurs in the particulate phase, after forming salts upon reaction with acidic gases (ammonium nitrate and ammonium sulphate). Information on the occurrence of amines in the atmosphere is scarce, but there is increasing evidence of the role of organic reduced nitrogen compounds in the formation and secondary growth of aerosols. In general agriculture is understood to be a strong source both for ammonia and organic reduced nitrogen. Grassland ecosystems may be alternately important sinks and sources for reduced nitrogen.   CORN will be integrated into a broad research initiative on the role of nitrogen fluxes from managed agricultural ecosystems. The training activities of the applicant will build on the exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'RAS superfamily and the interactions with their effectors: functional specificity' in the context of a Seventh Framework call.

assistant: **Objectives**

Ras genes code for small GTPases that act as GDP/GTP-regulated molecular switches. This exchange induces a conformational change that allows them to interact with their downstream effectors, and thus participate as central control elements in signal transduction. Mutated forms of the Ras oncoprotein are found in more than 30% of all human cancers, justifying the extensive research on them.      Ras effectors have convergently developed a common subdomain in their unrelated overall structure for their interaction with Ras. Although detailed knowledge about the thermodynamics and dynamics of the interaction with Ras has accumulated, the molecular mechanism at atomic detail of effector activation and thus specificity is still elusive.      Crystallographic, NMR, and other spectroscopic studies show that the flexibility of their so-called “switch regions” majorly contributes to the adaptability of the Ras proteins to their various partners, including disorder-to-order transitions upon binding to their partners, and “structural polymorphism” in their different complexes and in the unbound forms. This incorporates another degree of difficulty on the understanding of the Ras:effector association.       Although some studies have been previously carried out in order to rationalize the specificity of the Ras proteins towards their different effectors, they have been based only in the availability of Ras:effector crystal structures and taking a rather static point of view. In this work we intend to extend this to a large-scale bioinformatics and computational study, including driven-docking of Ras proteins and their effectors for which no complex structure is available but biological data supports complex formation. In a further step, Molecular Dynamics simulations both on the un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European decapod fisheries: Assessment and management' (EDFAM).

assistant: **Concept**

OBJECTIVES AND EXPECTED ACHIEVEMENTSThe overall objective of the EDFAM Concerted Action project is to provide a framework for the future data requirements, assessment and management of European decapod crustaceans. EDFAM will also discuss the optimum management structures and policies that connect the structure and dynamics of these resources, the fishing process and the socio-economic framework within which they are exploited. These actions are warranted given the low level of assessment work and consequent poorly defined management policies for the majority of these species and the importance of these resources to artisanal and offshore fisheries in Europe.Although some stock monitoring programs exist in many countries and assessment is carried out at the ICES WG level there is significant doubt regarding the robustness of the models and the advice to management.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Discovery of novel cancer serum biomarkers based on aberrant post translational modifications of O-glycoproteins (O-PTM-Biomarkers) and their application to early detection of cancer' (O-PTM-Biomarkers).

assistant: **Concept**

Early detection accomplished through an efficient screening programme remains the most promising approach to improve the long-term survival of cancer patients. Therefore there is a pressing need for the development of biomarkers, which detect the early changes for cancers where clinical symptoms only appear when the cancer has progressed, and treatment is ineffective. Our proposal, which addresses this problem at the European level, combines two unique features: i) large unique collections of sera with the potential for evaluation of diagnostic serum biomarkers with high statistical power, and ii) a novel technological approach involving specific immuno-detection of cancer-associated Post-Translationally Modified (PTM) glycoproteins in serum and of auto-antibodies to these glycoproteins. Glycosylation of proteins is one of the most abundant and complex forms of post translation modifications and the most important for the cell surface and secreted proteomes. O-glycosylation (O-PTM) is always altered in carcinomas, creating novel O-PTM epitopes which induce auto-antibodies.  Our Main Objectives are therefore to:- 1.Use a novel glycopeptide microarray technology to identifiy, evaluate and validate an O-PTM auto-antibody signature as an early diagnostic biomarker, focusing on breast, ovarian, pancreatic and lung cancers.  2. Develop and validate novel ELISA-type assays for cancer specific glycoforms of the MUC1 and MUC16 glycoproteins (targets of current serum biomarker assays).  The project brings together a Consortium with participants from 5 member States to fully exploit the potential of the unique serum banks at a European level by A. Integrating the expertise of world leaders in Glycobiology with Cancer Physicians and experts in biomarker assays. B. Establishing a fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'The Milky Way system as a laboratory to understand the role of galactic winds in galaxy evolution'.

assistant: **Innovation**

Massive stars and black holes in galaxies work together to launch multiphase, gaseous winds at velocities of hundreds of kilometres per second. These galactic winds play a fundamental role in the evolution of galaxies, as they regulate the formation of new stars by transferring gas from the disk to the surroundings. Despite the recognised importance of these phenomena, the physical processes behind them and their actual impact on the life of different types of galaxies are still unclear, mainly because observations in external galaxies lack the spatial resolution to study in detail these winds and to constrain theoretical models.This ERC project will rectify this situation by using the Milky Way and its main satellites, the Magellanic Clouds, as the closest wind laboratories in the Universe. A unique and powerful combination of observational and theoretical techniques will be used for this project. New, high-resolution, multi-wavelength data from forefront telescopes will be exploited to explore the nature of multiphase material traveling within winds in different galactic environments with unprecedented accuracy, reaching sub-pc resolution in the Milky Way and pc resolution in the Magellanic Clouds. Observational measurements will be accompanied by advanced theoretical modelling and state-of-the-art hydrodynamical simulations, which will ensure the most accurate interpretation of the data and will provide new invaluable insights on the physics of galactic winds.This project will reveal 1) the detailed physical conditions of multi-phase gas in outflows, 2) the origin and physical mechanisms that drive these winds, 3) the connection with galactic environment, 4) the broader impact on the evolution of different host galaxies. These are all critical aspects to understand t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Support to the Vice-Presidents of the ERC Scientific Council 2024-2025' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

This project provides the necessary support to the Vice-Presidents of the European Research Council Scientific Council (ERC ScC) to achieve key milestones and deliverables of the ScC, which are required under the Horizon Europe framework programme.Under the Horizon Europe programme, the European Research Council provides a competitive funding mechanism for investigator-driven frontier research at the European level. One of the key structural components of the ERC is the Scientific Council consisting of 21 eminent researchers and their President, representative of a large range of disciplines and institutional backgrounds. The ERC ScC independently establishes and oversees the ERC's scientific management and the implementation of the Work Programme, including the peer review and the selection of peer reviewers.The project aims to support the ERC Vice-Presidents, who, unlike the ERC President, act on an honorary basis, in the efficient and timely achievement of the ScC’s objectives in 2024 and 2025. The diverse responsibilities of the three Vice-Presidents of the ERC include the achievement of efficient and effective functioning of the ScC, its integrated operation together with the ERC Executive Agency (ERCEA), and effective interfacing with the scientific community, other funding agencies and the political institutions of the European Union. The project provides administrative and research support ranging from secretarial tasks to assistance in developing policy papers related to the work of the Vice-Presidents of the ERC for a period of two years.The project objective is to provide local administrative, operational, and advisory support for the three ERC Vice-Presidents. The project contains a single work package which encompassed all the various tasks associated with