RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Exploring the human gut microbiome at strain resolution' to be submitted under Horizon 2020.

assistant: **Abstract**

With the genome sequencing of hundreds of bacterial isolates per day and a vast and growing number of metagenomic sequencing projects on gut microbiomes in healthy and diseased people all over the world, it becomes feasible to explore the microbial diversity in us not only at the level of genera and species, but at strains. As two different strains of a prokaryotic species might only share 40% of the genes and can also have vastly differ in single nucleotide polymorphism (SNP) many aspects of a proper understanding of the microbial communities we host in the gut might only be revealed at this high resolution level. This proposal aims (i) to develop a robust methodology to characterize the SNP and gene content landscape from metagenomic shotgun data (ii) to explore patterns of variation in the human population to stratify geographically, but also in subpopulations such as families and to understand spreading patterns and the evolution of microbial strains as well as iii) to work towards medical applications, for example by monitoring fecal microbiota transplantation (FMT) at strain resolution or monitoring particular strain of interest in the population


**Keywords:** human microbiome, gut metagenomics, microbiomics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced Forest Fire Fighting' (AF3).

assistant: **Innovation**

In recent years, the frequency of large-scale forest fires has increased significantly owing to a number of factors including the effects of climate change, urbanisation, poor landscape management and malevolent acts. These so-called “Mega-fires” are particularly destructive and difficult to control with the technologies and systems currently available to fire fighters and emergency agencies. The AF3 project intends  to provide an extraordinary  improvement to the efficiency of current fire-fighting operations and to the protection of human lives, the environment and property by developing innovative technologies and means to ensure a high level of integration between existing and new systems.To reach this objective,  AF3 project focuses on the following areas:• Innovative active countermeasure: implementation of the novel AAFF (Advanced Aerial Fire Fighting) system to accurately and safely disperse extinguishing materials from high altitude by aircrafts and helicopters in any condition: day and night, regardless of weather, smoke and configuration of terrain. It will enable a quick 24H response, minimizing fire duration and damages. The AAFF system can be adapted to a wide variety of aircrafts or helicopters.• Innovative passive countermeasures: fast build-up of preventive defensive lines of  capsules to prevent the spreading of fire from forest to populated areas• Early detection and monitoring: integration and deployment of diverse systems including satellites, aeroplanes, UAVs, and both mobile and stationary ground systems for the early detection of fire and for monitoring the propagation of smoke and toxic clouds.• Integrated crisis management: the innovative AF3 Core Expert Engine will perform overall coordination of all fire fighting missions.The results of AF3 w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Versatile optical frequency comb' (2021-2027).

assistant: **Innovation**

Frequency combs are optical sources that can be used as rulers. Any unknown frequency can be very precisely measured by comparing it to the nearest tooth of the comb. The technology has revolutionized metrology and spectroscopy among others and its inventors were awarded the Nobel Prize in 2005.To obtain a frequency comb, a periodic optical pattern must be generated. There are different ways of forming optical patterns and different technologies are used, depending on the required comb spacing (which corresponds to the repetition-rate of the pattern). For example, high repetition rate combs used for calibration of astronomical spectrographs, while low repetition rates are used for spectroscopy or ranging.We propose to fabricate a completely novel device whose repetition rate can be tuned over three orders of magnitude, covering most applications of frequency combs. The device would merge the advantages of the existing technologies, in terms of power and stability.We expect our device to have a strong impact on the market of frequency comb generators and will investigate different paths towards commercialization of the prototype.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Biosynthesis of Plant Cell Wall Polysaccharides ¿ Glyco-metabolons and Host-pathogen Interaction', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

A cell wall surrounds every cell in a plant. It supports and determines the plant¿s physical form and provides a barrier against invading pathogens. The wall polysaccharides are synthesized by glycosyltransferases (GTs) located in the Golgi vesicles. Char acteristic signature structures for Golgi targeting have not been defined and this raises a question as to how the targeting of the GTs occurs. Many Golgi enzymes are known to be targeted by interactions with other proteins. We reason that this could be pa rticularly true for enzymes involved in biosynthesis of complex polysaccharides, which are likely to be synthesized by protein complexes. The objective is to identify the mechanism for Golgi targeting of the GTs from the perspective of protein-protein inte raction. This targeting will be investigated using fluorescent fusion proteins and confocal laser scanning microscopy. Direct protein-protein interactions will be elucidated by comparing targeting in wild type background and in mutants lacking components o f the biosynthetic machinery as well as by fluorescence resonance energy transfer (FRET).  Invading bacterial pathogens interact with the cell wall and in some instances form biofilm. Therefore, cell wall components, particularly the polysaccharide struc tures and oligosaccharides derived from these, may be important stimuli in this context. GT mutants will be analyzed for their susceptibility to bacterial attachment, biofilm formation, and subsequent disease development. Because microbial biofilm is a con tinuing problem in both medical and industrial settings, the results have potential for technological applications, such as for designing coating materials for medical devices and in the food industry. The specific scientific goals are: - To identify novel Golg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of cost-effective high energy density plastic li-ion battery for portable computers (PLASTIC LI-ION BATTERY)' under Fifth Framework.

assistant: **Concept**

The project addresses the development of a new, cost-effective process for the manufacture of lithium-ion polymer batteries, initially as a power source for portable applications, with potential penetration into higher energy sectors (incl. EV's) within 3-5 years.The prime goal is to deliver a rechargeable battery pack (a 12V/4Ah module) for a portable computer with an energy density of 200 Wh/kg for 500 cycles. Battery management will be included to give safe operation. Additional goals include a 50% reduction in process costs; a 20% reduction in materials costs; and the use of less organic solvents in the process, resulting in significantly reduced emissions.The battery comprises a laminate of plastic electrodes (anode and cathode) separated by a polymer electrolyte: all three components are to be fabricated as tapes through a novel extrusion process, combined with in-line electrolyte impregnation into both electrode- and electrolyte-tapes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Biocatalytic Fluorescence Switch-On Polymerizations for Signal Amplification in Ultrasensitive Diagnostics and Biosensing of Malaria' under Horizon Europe.

assistant: **Concept**

Malaria is one of the most catastrophic infectious diseases, causing nearly 250 million deaths in 2021, according to WHO. Although malaria is curable, delayed diagnosis is the leading cause of death in malaria patients. The major obstacle in malaria diagnosis is clinical assessment by conventional methods, which requires well-trained clinicians and expensive equipment. Moreover, point-of-care diagnostic tests are not sensitive enough to accurately detect low levels of parasitemia. Thus, there is an urgent need for a rapid, accurate, and highly sensitive malaria diagnostic method based on the detection of parasite biomarkers in the bloodstream and amplification of weak parasite signals by novel methods.In recent years, atom transfer radical polymerization (ATRP), a controlled radical polymerization, has been studied as an attractive method for signal amplification in biosensing because the chain reaction accumulates monomers in the form of polymers at the site of polymerization. In addition, clinically relevant metalloproteins have been detected using this polymer-based signal amplification technique.Herein, the aim of this work is to develop biocatalytic fluorescent switch-on polymerizations with a triple signal amplification strategy for ultrasensitive diagnostics and biosensing of malaria. The polymerizations will be used in assays for malaria diagnosis based on hemozoin (metabolic byproduct of all Plasmodium species) and in immunoassays that involve antibody-peroxidase conjugates (lateral flow immunoassay, enzyme-linked immunosorbent assay (ELISA), and immunofluorescence staining) for low abundance malaria antigens. The diagnostic platform will be a collective combination and use of multiple independent technologies in a unique design to detect realistic and feasible
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Low cost, super efficient and jet fire resistant cryogenic thermal insulation half shell structures using geopolymer technology for LNG pipeline applications' (CRYOWRAP), addressing dissemination and exploitation.

assistant: **Impact**

Natural gas may be liquefied at -160oC thereby reducing its volume and providing an economic means for its transportation. Liquefied natural gas (LNG) enables gas markets to be connected with more distant export sources thereby improving market competitiveness and stability. Effective thermal insulation is critical to energy management throughout the LNG value chain, impacting on competitiveness and profitability. Furthermore, durability and fire protection are important to ensuring safety and protection of capital infrastructure.Existing insulation systems are based on cellular foam or powder insulation structures, pipe-in-pipe vacuum insulated structures, or hybrid systems combining foam / powder and vacuum. Whilst cellular and powder materials are low cost, they are time consuming to install, rapidly degrade under cryogenic temperatures and are fixed in place preventing routine inspection. Whilst offering high performance, vacuum systems are expensive, complex to install and rapidly lose their vacuum with time. None of the existing systems offer adequate fire protection. The CryoWrap project will develop a highly innovative LNG insulation system incorporating emerging geopolymer & aeroclay material science & novel production processes, achieving:• Enhanced insulation performance and service lifetime (improved energy & maintenance cost efficiency)• High jet fire resistance performance for protection of infrastructure assets (Prioritising safety and added value)• Energy efficient production of standardised and unique insulation half shell shapes (reduced environmental impact & cost competitiveness)• Rapid on-site installation (greater flexibility and reduced installation costs)• Efficient removal & re-installation (enabling routine inspection & ease of maintenance)The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Examination of Practical Aspects of Innovative Bonded Composite Repair Techniques'.

assistant: **Innovation**

Even though adhesively bonded composite repairs exhibit significant advantages in terms of mechanical efficiency compared to mechanically fastened ones, they are at the same time extremely sensitive to process parameters variations. Small deviations against the repair specifications (e.g. surface preparation) may lead to disproportionally larger consequences to the final mechanical performance of the repair and, consequently, to the integrity of the structure. Moreover, the inevitable differences between laboratory and repair shop conditions, may lead to the cancellation of promising technological achievements for “practical” reasons, because the required conditions could not be easily met in standard practice. The scope of this proposal is to examine from a practical application point of view the innovations achieved within GRA Task 1.3.6-02 for bonded composite repairs, in order to facilitate their transfer to production conditions. For this reason, the whole chain of process steps which have to be followed for the performance of a typical repair will be executed in standard repair shop conditions, in terms of facilities, equipment, tooling and personnel training. Potential contradictions of innovations developed by the GRA to standard repair practices will be identified and alternative solutions will be proposed, to facilitate their efficient transfer to production standards and requirements. The project success is guaranteed from the background of the consorium: a) GMI Aero, a bonded composite repair equipment manufacturer and supplier of major airlines and MROs, with over 25 years experience in the development of repair equipment, techniques, advanced solutions and technicians personnel training, and b) NTUA, a leading institute in the research of bonded composite
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cracking the Post-Translational Modification Crosstalk Code in S. cerevisiae' (PTMtalk).

assistant: **Concept**

Post-translational modifications (PTMs) regulate all aspects of protein functionality. Dysregulation of PTMs or the enzymes that regulate them is frequently associated with disease. Far from working in isolation, PTMs crosstalk with each other creating decision-making circuits that regulate the cellular adaptation to fluctuating environments. PTM crosstalk is a regulatory layer of the proteome across the tree of life. However, to what extent and how PTM crosstalk regulates biological processes is a long-standing question in biology that is experimentally challenging to tackle. The challenges lie in the natural complexity and infinite combinatorial possibilities of PTMs, and the lack of unbiased systematic methods to study their function. We will use a combination of state-of-the-art CRISPR-based editing methods to construct 30.000 PTM-mutants in all the proteins involved in the signalling-to-chromatin pathways, and a scalable systems biology approach based on reverse genetics and chemical genomics to profile these mutants under 150 stress conditions. Mutants with similar phenotypic profiles are functionally associated, allowing us to infer functional relationships for PTMs, regulators and conditions. These functional associations will provide conditional regulatory PTM crosstalk events at an unprecedented scale. We will further mechanistically dissect the function of selected PTM crosstalk events by interrogating protein activity, cellular localization and interactions. Moreover, we will dissect their directionality and modularity. We expect these findings to be transferable to other eukaryotes due to the high degree of conservation in these core biological processes. Overall, this project will revolutionise the PTM field providing ground-breaking insights into the func
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Breaking the Inequality-Crime Cycle: Biases in Police Decisions, 'What Works' in Prison, and Firm Demand for Workers with Criminal Records' under Horizon Europe.

assistant: **Concept**

Economic inequality across the population implies vastly unequal opportunities in many dimensions that can impact an individuals chance of entering the justice system. One such channel via which this can occur  even holding criminal behavior constant  is unequal treatment by agents of the justice system (e.g. police). The consequences of such partiality is not trivial: once in the system, it is hard to get out. And to the extent that convictions and sanctions result in worse outcomes (e.g. employment) for offenders and/or family members, the cycle of crime and economic inequality will perpetuate for current and future generations. This program pushes forward the evidence base on three channels (police, prisons, firms) through which this cycle can be broken. Part 1 aims to measure and study the adoption of implicit bias training programs by police agencies. Despite such programs being a go-to response of agencies accused of bias, there is almost no knowledge on how/whether they impact officer behavior. Part 2 addresses the knowledge gap on what (specifically) works in prison. First, we will study the unintended impacts of two Swedish sanction reforms onto untreated populations. (i) Does more time in prison have spill-over effects for family members? (ii) Did the introduction of electronic monitoring impact the conditions and outcomes of ineligible offenders left behind in prison?  Second, we will open the black-box of prison healthcare to study how in-prison treatment (diagnoses, medication, vaccines, programs) impacts post-release health, medication adherence, and crime.Part 3 aims to further our understanding of the employment opportunities  or lack thereof  for workers with criminal records (WCR). We will use Swedish registers to study (i) the extent to which WCR are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Brain connectomics: modeling disconnection syndrome in Multiple Sclerosis' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Brain architecture or connectivity is complex and defines the basis of cognitive processing. Recent studies have revealed new insights about its organization by the combination of structural Magnetic Resonance Imaging (MRI) such as tractography (using Diffusion Spectrum Imaging, DSI) and functional MRI (fMRI) using resting-state. However, the complexity of brain connectivity and technical limitations prevent a comprehensive understanding of its organization. For this reason, the use of disease models producing disconnection syndromes, such as Multiple Sclerosis (MS) are important approaches for improving our understanding about brain organization. Moreover, MRI analysis of MS by DSI and fMRI can provide new insights on MS pathogenesis and development of new biomarkers of the disease, helping to solve the “clinical-MRI paradox”, namely the low correlation between MRI findings and clinical course.In this proposal we present new models for studying brain connectivity by analyzing MS. We intend to use state-of-the-art approaches in brain connectomics and apply inter-disciplinary techniques ranging form different MRI modalities to network analysis and image processing techniques. The candidate has a strong technical background and a PhD in a very related area - the technical aspects of the imaging techniques. The host group is strong in applied clinical research, with focus on MS, imaging, cognitive sciences and systems neurosciences. The host group has several ongoing collaborations with top researchers in cognitive neuroscience and connectomics. Finally, the findings and techniques that will be developed in this project can be transferable to clinical practice but also with minor modifications applied to similar neurological diseases and the research involving general ques