RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Control of Central Nervous Sytem inflammation by meningeal macrophages, and its impairment upon aging' to be submitted under Horizon 2020.

assistant: **Abstract**

Immune responses within the central nervous system (CNS) can drive fatal neuroinflammation and age-related neurodegeneration as seen in the EU but are also crucial to prevent microbial spread into the CNS. It is thus important to understand and control the parameters involved in CNS inflammation. Most studies have focused on the contribution of immune cells localized within the CNS parenchyma. While searching for novel strategies to control neuroinflammation, we and others have found that the nature and activation state of immune cells at the brain surface can profoundly influence CNS inflammation. The parenchyma is enveloped by membranes referred to as the meninges that harbor a vast network of macrophages juxtaposed to blood vasculature, thus ideally positioned to detect pathogens and orchestrate immune cell recruitment into the CNS. The overarching goal of this project is to understand the role of resident meningeal macrophages in initiating and controlling CNS inflammation. To this end, I intend to study the heterogeneity of myeloid subpopulations at steady-state and their differential ability to mount an immune response following a microbial challenge. Furthermore, I will define how natural inflammatory aging impairs the induction of CNS immune responses by meningeal macrophages, and will propose strategies to restore CNS immunity at the brain borders to protect this vital organ. This will be accomplished using combinatorial approaches, including transcriptomics, flow cytometry, histo-cytometry and intravital imaging. Macrophages will be manipulated using transcranial drug delivery and transgenic mice. Sharing skills, expertise, and tools with my host institution will be a key component of this project. Understanding meningeal immunity will open avenues for the tre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Plant Production of Vaccines' (PLAPROVA).

assistant: **Concept**

Advances in the technologies for expressing proteins and extracting them from plants have allowed several plant-made products to be assessed for safety and efficacy. The results have been favourable and have culminated in the demonstration that plant-produced vaccine can protect target animals against challenge. However, most of these successes have concerned the production of antigens which had previously been produced using established methods such as mammalian cell culture. For plants to fulfil their potential as a means of producing vaccines, it is now imperative that methods are developed for the rapid production and characterisation of a large number of vaccine candidates. This project will exploit recent developments in transient expression technologies to screen a range of vaccine candidates in plants. These methods can produce milligram quantities of candidate proteins in a matter of days using only small amounts (tens of grams) of plant tissue. The project will concentrate on screening vaccine candidate proteins which are capable of forming virus-like particles (VLPs), as such particulate structures are known to be potent stimulators of the immune system.  Furthermore, they can be used as carriers of additional immunogenic sequences for the developments of novel vaccines. The project will focus on diseases which are particularly relevant to both the EU and Russia, including Avian Influenza virus (AIV), Blue Tongue Virus (BTV) Porcine Respiratory and Reproductive Syndrome Virus (PRRSV). The ability to screen many candidate VLPs will result in the development of novel vaccines against these and other important pathogens. At the same time as the screening is carried out, methods will be developed to allow the rapid translation of the information gained through th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Base metal-catalytic cross-coupling methodologies towards sustainability'.

assistant: **Objectives**

Catalysis is today exploited for preparing ca. 90% of chemical and pharmaceutical products. Use of catalysts allows for efficient chemical transformations, limiting the energy consumption and improving selectivity and atom economy. However, a large number of catalytic systems rely on noble metals (e.g., Pd, Pt, Rh, Ir, Au), with associated sustainability and toxicity issues. Indeed, all these metals are undergoing strong price fluctuations and will face supply limitations in the future. Moreover, given the toxicity of most precious metals, the tolerated threshold in fine chemicals and APIs is very low, with associated purification costs (solvents, energy, generation of waste). For these reasons, replacement of noble metals with the cheaper and generally less toxic 1st row transition metals (TMs) - such as Mn, Fe, Co, Ni, Cu - is becoming a compelling goal for chemists, as well as a need for society. However, this goal also represents a tremendous challenge, as the typical reactivity of 2nd and 3rd row TMs cannot be easily transferred to 1st row TMs, due to their different electronic structure: the so-called ""base metals"" tend to form high spin complexes and to engage in single electron transfer rather than in the multielectron redox steps typical of noble metals.NextBase is an intersectoral consortium of research groups with a strong expertise in catalysis, who will join forces to take the challenge of noble metal replacement in cross-coupling reactions - a class of transformations of high industrial importance for the production of fine chemicals and APIs. Synergies and complementary types of expertise within the DN will be exploited (i) to harness the reactivity of 1st row TM for several types of cross-coupling, which will be also applied to industrially relevant ta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sustainable Soil Management Decision Support System in Viticulture' (SOSVITI).

assistant: **Concept**

Soil erosion and degradation pose significant threats to agricultural sustainability, food security, and economic stability. Despite awareness, conservation measures are often neglected due to barriers such as cost and information gaps. Addressing these challenges requires multidisciplinary approaches integrating scientific research, stakeholder engagement, and technological innovation. The project aims to develop comprehensive soil erosion models, understand stakeholders' perceptions, and create a decision support system (DSS) for vineyard management. The objectives include developing innovative solutions, enhancing soil health, mitigating erosion risk, understanding social factors, and promoting sustainable practices. The project emphasizes multidisciplinary integration and knowledge transfer, leveraging advances in artificial intelligence, big data analytics, and cloud computing to address the impacts of climate change and promote agricultural ecosystem conservation.The proposal will be developed by 11 partners from 6 European countries, with 6 academic organizations, 4 SMEs and one no-profit organization with different backgrounds.


**Keywords:** Soil erosion models, climate change, satellite data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Modified Gravity: from Compact Objects to Dark Energy' to be submitted under Horizon Europe.

assistant: **Abstract**

The origin of the accelerated expansion of the Universe remains elusive. The so-called Dark Energy might be a manifestation of modified gravity at very large scales. While near-future observatories will improve the current bounds on such a possibility, they will not likely be conclusive as to its nature. An opportunity arises from the study of modifications of gravity at shorter scales, specifically around compact objects like black holes and neutron stars, recently made possible through gravitational-wave observations.This project aims to dramatically improve the constraints on cosmological modifications of gravity by means of an interdisciplinary approach involving tools from High Energy Physics, and both astrophysical gravitational-wave and cosmological observations. Modified gravity dynamics at different scales can be described in a model-independent way as Effective Field Theories according to symmetry principles. Strong constraints will come from a combined theoretical and phenomenological study within this framework. Both analytical and numerical tools will be developed and employed to qualitatively and quantitatively compute the expected signatures on gravitational-wave astrophysics, allowing to hold these models against observations. The constraints will then be translated to the cosmological modifications of gravity, drawing novel conclusions as to which theories can consistently explain Dark Energy while satisfying bounds across a large range of scales.Ultimately, this project will foster the collaboration among the High Energy Physics, Cosmology and Gravitational-Wave Astrophysics communities, enabling a much faster and efficient progress in the field of modified gravity in general. This includes a more focused use of the available computational resources fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Investigation of the role of glycans in atherosclerosis' to be submitted under Fourth Framework.

assistant: **Abstract**

The proliferation and migration of vascular smooth muscle cells (VSMC) from the tunica media to the neointima are key events in the development and progression of atherosclerosis. We have recently shown that PDGF specifically stimulates proliferating VSMC, in culture, to secrete a 340-kDa glycan molecule which shares structural characteristics with hyaluronic acid (HA) and has a potent antiproliferative activity on VSMC. Studies on the migration of VSMC through an artificial basement membrane layer revealed that the 340-kDa HA molecule enhances VSMC migration towards PDGF. These results indicated that the 340-kDa HA may be involved in the processes associated with the formation of atherosclerotic lesions. The objectives of this proposal are: 1 ) to substantiate the involvement of glycans in the formation of atherosclerotic lesions by investigating possible quantitative and/or qualitative differences of the glycan molecules between human atherosclerotic arteries and arteries without atheromatosis (mammary artery), from the same patient; 2) to further investigate the molecular mechanism by which PDGF stimulates the secretion of the 340-kDa HA by VSMC and 3) to study the possible involvement of matrix metalloproteases (MMPs) during the 340-kDa HA-induced migration of VSMC. The elucidation of the above questions will have a profound impact in the understanding of the cellular dysfunctions and the regulation of the local inflammatory responses involved in atherosclerosis. The training objective will be to acquire research experience regarding: 1 ) the biochemistry of MMPs, glycans and growth factors in relation to atherosclerosis, and 2) techniques relevant to histopathological identification of atheromatic and physiological arteries, under the guidance of experienced scient
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Chromatin Regulation Of Normal And Malignant Haematopoiesis' (ChRONAM-H).

assistant: **Concept**

Chromatin Factors (CFs) comprise a diverse family of proteins that elicit key regulatory epigenetic activities during the regulation of cellular fates. Although this heterogeneous group has been traditionally considered a static toolkit of epigenetic enzymes deployed to lineage-specific loci under the control of Transcription Factors (TFs), recent works have shown that CFs are crucial determinants of developmental lineage decisions that assemble into dynamic chromatin regulatory complexes with exquisite cell-type-specific composition. Hematopoiesis is a key developmental process largely dependent on Chromatin Factors. Importantly, CFs are the most recurrently mutated protein category across diverse blood malignancies. In fact, alterations in some of these proteins, like MLL fusions, have been proven to be central drivers of malignant transformation. However, in spite of this proven relevance, the contribution of most Chromatin Factors to blood lineage commitment remains largely unexplored; moreover, even for well-studied complexes such as SWI/SNF Polycomb or COMPASS, very little is known about the mechanisms that govern their locus-specific assembly and activity during cell fate specification.My project Chromatin Regulation Of Normal And Malignant Haematopoiesis (ChRONAM-H) proposes a multidisciplinary framework to explore the functions of CFs during hematopoietic lineage commitment and malignant transformation. I will combine high-throughput functional measurements with state-of-the-art chromatin profiling technologies to unveil the lineage specifying roles of a large number of CFs and orthogonally link them within existing TF-centric networks in both normal and malignant hematopoiesis. This will shed light on the molecular behavior of chromatin regulatory complexes, p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Drug Trafficking and Politics: Structuring and Adaptation of Organized Crime in Bolivia's Last Authoritarian Decade (1971-1982)' (1971-1982) targeting Horizon Europe.

assistant: **Abstract**

NARCOPOLITICS aims to enhance our understanding of the global dynamics linking drug trafficking and political power through the case study of Bolivia between 1971 and 1982. During this period, Bolivia became a pivotal player in drug trafficking due to its extensive coca plantations, the Santa Ana cartel led by Roberto Suarez Gómez, and persistent ties between drug smugglers and political institutions ruled by the military, aligned with the National Security Doctrine.Adopting a long-term historical perspective and considering organized crime as a significant Cold War non-state actor, NARCOPOLITICS has three objectives: examining the role of drug traffickers in Bolivia's political developments and their adaptability to changes in the national and regional context; identifying the political conditions under which the Santa Ana cartel intersected with political and ideological spheres and assessing the consequences; and analyzing and comparing measures—both official and unofficial including operations of security agencies—taken by the three US administrations during this period, examining the long-term impact of the “war on drugs.”The research methodology combines recently opened archival documents and judiciary sources from different countries, providing a comprehensive narrative and analysis. This approach aims to address issues such as difficulty in identifying involved actors and ensuring data reliability.The rise of state-narco networks in countries like Mexico, Guinea-Bissau and Afghanistan highlights the urgent need for comprehensive research and policy responses. Understanding the historical context and evolution of drug-influenced states, as exemplified by Bolivia's experience, can provide critical insights into addressing these modern challenges.The Fellowship wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Nanoscintillators to potentiate brain cancer radiotherapy:  from physics to preclinical trials' (RADIANCE) targeting Horizon Europe.

assistant: **Abstract**

More than 50% of cancer patients undergo radiation therapy (RT) in the course of their treatment. However, because of a lack of specificity for tumor tissues, delivering therapeutically effective doses of X rays with tolerable toxicity on healthy tissues remains a challenge. Glioblastoma multiforme (GBM), the most common primary brain cancer in adults has a dismal prognosis despite an aggressive standard-of-care. Developing new strategies to improve the therapeutic index of RT is therefore of major importance. The aim of this project is to comprehensively study the multifaceted radiotherapeutic effect of nanoscintillators (NS), and determine how to harness these effects to improve the therapeutic index of RT. By converting high-energy photons such as X-rays into UV/visible photons, NS can augment RT by various effects. These include radiation dose enhancement, radioluminescence-induced photodynamic therapy and DNA damage generated by UV-radioluminescence. This project has three main objectives: 1) To elucidate the physical and photochemical origins of the radiotherapeutic effects of NS using spectroscopic studies to identify the reactive oxygen species and DNA lesions generated upon X-rays; 2) To study the biological impact of the NS on 3D models and in syngeneic rat models of GBM; 3) To develop an in silico program that simulates the efficacy of prospective NS, and studies the impact of their composition, size and morphology. This will tailor future NS to specific malignancies with distinct biological properties. With this innovative methodology and an interdisciplinary approach that ranges from physics to biology, this project will provide ground-breaking fundamental knowledge on the radiotherapeutic effects of NS that may lead to highly valuable and clinically transl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The role of necrotrophic effectors in the ability of Botrytis and Monilinia species to infect host plants' (NECROFUNGI) under Horizon 2020.

assistant: **Objectives**

Botrytis cinerea and Monilinia fructicola are both devastating pathogens that can cause decay in a broad range of hosts during pre and postharvest handling. Despite the current use of chemical fungicides, both fungal pathogens are still responsible of important economic losses worldwide. The knowledge of pathogen virulence mechanisms is an important step to guide the search for new control strategies alternative to the fungicides currently in use. Crucially, the genome sequences of both B. cinerea and M. fructicola can be exploited to identify genes and proteins that determine their ability to infect host plants.  By applying molecular and bioinformatic analysis, NECROFUNGI aims to identify genes that encode necrotrophic effector proteins which only kill their specific host, but do not affect other plant species. The identification of genes responsible for disease will lead the way towards new strategies to control plant diseases based on the development of new classes of chemicals that are not directly toxic to fungi and to design more efficient breeding strategies. Wageningen University has an extraordinary resource to carry out this research. The host will train Dr. Vilanova in molecular and bioinformatic techniques in the study of the B. cinerea and M. fructicola genomes, providing the necessary skills for her to establish a similar facility in her home country in the study of M. fructicola where none currently exists. In turn, the fellow will bring specific expertise in postharvest fruit-pathogen interactions, not currently available at the host institution. The multidisciplinary perspective adopted, combining fruit-pathology, comparative genomics, molecular biology and bioinformatics will build the necessary information to control these two devastating pathogens b