RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Accelerated ageing by means of plasma erosion, an ultra-rapid method for prediction of paint durability' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The overall objective of this project is to develop a method for ultra-rapid weathering of paints based on plasma erosion, which should correlate with natural weathering results in terms of physical and chemical properties. This new method will be proposed for use in discriminating between good and bad paint performance at an early stage and in predicting the service life of coatings. An additional objective is to acquire information about the mechanisms of the degradation process by comparing plasma erosion and natural weathering.Plasma erosion tests have been performed on several different paint systems and evaluated mainly by means of gloss and colour measurements. The combined UV and plasma exposure (first UV then plasma) has not given the improved correlation with natural weathering as expected. Although the desired correlation with natural weathering was found for some coating systems, it has not been possible to find a plasma condition that will give the desired correlation with natural weathering for all investigated paint systems. The use of plasma erosion method as a standard method for prediction of paint durability has therefore been considered as premature at present. More research and development is needed. Future research should focus on low power (no or low ion density) plasma and/or VUV exposure experiments for possible distinction between the relative performances of e.g. different grades of durable long-life polyester coatings.BackgroundPaint manufacturers recognise the importance of the durability of applied paint layers and are continually reformulating to obtain improved performance and minimised degradation. They are, however, faced with the problem of how to quantify this property of durability. The obvious method is to expose paint films to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Femtosecond laser processing for micro- and nanopatterning of metal halide perovskite thin films for enhanced light management in solar cells' (SPARKLES) targeting Horizon Europe.

assistant: **Abstract**

Photovoltaic technology stands as a beacon in the challenge to reduce CO2 emissions by maximizing the use of solar energy. Over the past decade, perovskite materials have emerged as game-changers, offering a powerful combination of affordability and high efficiency. In addition, their remarkable properties make them prime candidates for solar cell applications and are called to revolutionize photovoltaic technology. However, there is still room for improvement in enhancing their light management capabilities. Numerical simulations in perovskites have shown the potential of nanopatterning for the enhancement of light management, but the current landscape of nano- and micropatterning techniques is often time-consuming and unsuitable for large-scale industrial applications. This bottleneck hampers the realization of the full potential of perovskite solar cells.SPARKLES is a pioneering project aimed at revolutionizing perovskite technology. The main objective is to develop an innovative approach that enables rapid, large-area patterning of perovskite thin film surface in a single and efficient step for enhancing light management. This is possible thanks to femtosecond laser processing, a cutting-edge technology that creates Laser-Induced Periodic Surface Structures (LIPSS). This finely tunable periodic line-pattern promises to optimize the light management capabilities of perovskite solar cell devices. LIPSS are the result of an interference phenomenon which allows patterning large areas in the blink of an eye, making them a perfect fit for industrial-scale production. The novel strategy proposed in SPARKLES achieves mask-less patterning without the need for harmful chemicals, ensuring a clean and sustainable process. SPARKLES is poised to illuminate the future of perovskit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Global analysis of the vaccinia genome.' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Vaccinia virus, a close relative of variola virus the causative agent of smallpox, is a large double-stranded DNA virus encoding more than 260 genes that replicates in the cytoplasm of the host cell. To date the function or location of only ~100 viral proteins has been determined although the genome has been available for 11 years. The project aims to take a global genomic approach to identify new vaccinia proteins involved in viral morphogenesis and those responsible for the dramatic cellular effects observed during vaccinia infection. These include stimulation of cell motility, changes in cell adhesion, re-organization of the actin and microtubule cytoskeletons as well as destruction of the centrosome to name but a few. I will initially PCR all vaccinia genes and the resulting open reading frames will be cloned into a series of viral and CMV expression vectors containing epitope and GFP tags. These clones will be used to localize each gene product in fixed and live cells in both infected and non-infected cells. This first screen will immediately provide large amount of information as localization will often implicate function and will identify viral proteins that induce profound cellular changes. I will subsequently further characterize proteins that are associated with the cytoskeleton or induce changes in cell morphology, adhesion or motility when expressed although other interesting proteins will not be neglected. Selected proteins will be studied using a combination of approaches including GFP imaging, biochemical isolation coupled with mass spectrometry analysis, anti-sense expression and RNA interference and the ability to knockout viral genes by homologous recombination.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Aetiology, ultrastructure and development of intracellular endoparasitic protozoa infecting ibero-Atlantic fishes'.

assistant: **Objectives**

The objective of the present project is to provide fundamental information on the aetiology, phases of infection, and demographic infection values of intracellular protozoam diseases of Wee important commercial fish species (the blue whiting Micromesistius poutassou, the Atlantic horse mackerel Trachurus trachurus and he Atlantic mackerel Scomber scombrus.An extensive list of intracellular endoparasitic protozoan diseases will be compiled in order to have(a) a strong scientific reference base upon which to justify epidemiological control programmes and the draft regulations for seafood products, and(b) classify the disease agents of marine fish populations according to a level of concern.The aetiology , and sequential development (especially their sporogenesis and life cycle stages) of more prevalent parasites will be described for those commercially-important fish in the ICES IXa division.The following tasks will be addressed:(a) Aetiology of intracellular endoparasitic protozoan diseases
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bioreactive food expiry label that mimics the actual decay of food for a reliable and accurate method of reducing food waste' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Current printed expiry dates are inaccurate and conservative estimates, which can’t predict the condition that the food product is exposed to. This results in 33% of all food being wasted (1.2 billion tonnes). Of this food 60% is still edible and was disposed of prematurely. Food waste also causes 1.6 billion tonnes of greenhouse gases, wastage of 40-50% of drinking water and many retailers and consumers to spend excess money on wasted food.Mimica Touch is a tactile freshness indicator and food expiry label that uses specifically designed gelatine to accurately mimic the decay rate of food. The gel is exposed to both the same conditions as the food and the off-gases emitted from expiring food, thus giving a real-time indication of the product’s freshness. The gelatine is specifically calibrated to experience and mimic each food product’s decay. It offers many benefits: Low-cost, accurate solution; Food waste reduction; Increased food safety; Valorises waste material; Improved social inclusion; and Applicable in a wide range of uses and industries.Mimica Touch is the only tactile food expiration indicator that is biologically active, resulting in an unrivalled accuracy. Not only can it significantly reduce food waste but also offers and increase to profits and savings for all stakeholders. Mimica resides in the UK, where the technology was first developed and where significant links with customers and users of the solution have been secured. Within the project, Mimica intend to hire personnel to identify commercial partnerships and possible clients throughout Europe. Mimica foresee future employment growth of 32 jobs in the early stages of commercialisation.The proposed work in Phase 1 of the SME instrument fits into the overall plan to reach market by contributing the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Non-intrusive solution for Obstructive Sleep Apnea Syndrome' (Sleepwise), addressing dissemination and exploitation.

assistant: **Impact**

The Obstructive Sleep Apnea (OSA) is a chronic disease that afflicts approximately 100 million people, however, nearly 80%of people with this condition remain undiagnosed. Sleep Apnea has serious medical consequences but it is alsoeconomically costly. In the USA alone the estimated economic cost of undiagnosed OSA is $149.6 billion.The diagnosis of OSA is typically made after a polysomnography (PSG), an expensive test that requires an overnight stay ina sleep laboratory wired to up to 15 different devices. Today the use of Home Sleep Tests are increasing due to are lessintrusive and cheaper, however, they are subject to patient error in attaching the sensors, require previous training, arecumbersome and are not appropriate for children.Tarsio Medics is a technological company that has been working during more than 10 years together with the Pneumologyunit of the Hospital Trias i Pujol to develop SleepWise, an innovative system for the exploration and diagnosis of OSA basedon image processing.Our patented SleepWise system is non-intrusive, low cost, does not require training. It provides automatic analysis for sleepprofessionals, is more reliable because it can infer sleep/awake periods and is more versatile as it can also detect othernocturnal movements such as restless legs, parasomnias and epilepsy.We plan to monetize SleepWise offering a complete end-to-end service to doctors, hospitals and health insurancecompanies. The market potential is large: the global sleep apnea diagnostic system market is €341.7, €205.06 of themrelated with Home Sleep Tests.Currently we have a beta version of the SleepWise. Now we are applying to the SME Instrument Phase 1 to carry out aFeasibility Study to assess operational, technological and economic viability as well as to elaborate a Bu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Completion of the genome of sulfolobus solfataricus'.

assistant: **Objectives**

THE PRIMARY OBJECTIVE OF THIS PROJECT IS TO CONTRIBUTE TO THE COMPLETION OF THE GENOME SEQUENCE OF THE ARCHAEAL HYPERTHERMOPHILE SULFOLOBUS SOLFATARICUS. THIS PROJECT WAS STARTED IN 1993 BY THREE CANADIAN LABORATORIES SPONSORED BY THE CANADIAN NATIONAL RESEARCH COUNCIL. 25% OF THE 3 MBP GENOME HAS BEEN SEQUENCED AND ABOUT ONE THIRD WILL BE COMPLETED WHEN THEIR 3 YEAR GRANT TERMINATES IN SUMMER 1996. THEY HAVE BEEN PROMISED A THREE YEAR RENEWAL, AT THE SAME FINANCIAL RATE AS BEFORE, WHICH MEANS THAT THEY WILL HAVE SEQUENCED TWO-THIRDS OF THE GENOME BY THE END OF 1999. WE ARE THREE EUROPEAN UNIVERSITY LABORATORIES AND ONE INDUSTRIAL LABORATORY WHO HAVE NEGOTIATED WITH THE CANADIAN GROUPS THAT WE WILL SEQUENCE THE REMAINING ONE THIRD OF THE GENOME. THE CANADIANS HAVE A LINEAR COSMID LIBRARY COVERING ALMOST THE WHOLE GENOME AND THEY WILL PROVIDE US WITH COSMIDS COVERING ABOUT ONE THIRD OF THE GENOME. THE THREE EUROPEAN UNIVERSITY LABORATORIES WILL PERFORM SUB-CLONING AND SEQUENCING AND NOVO-NORDISK A/S WILL HELP BOTH WITH PROCESSING OF THE SEQUENCING DATA AND WITH DEVELOPING SOFTWARE FOR ACCESSING REGULATORY SIGNALS, MOTIFS AND CODING REGIONS IN THE GENOME SEQUENCES WHICH ARE OF POTENTIAL INDUSTRIAL INTEREST; THESE THEY WILL MAKE AVAILABLE TO THE INDUSTRIAL PLATFORM. THE NEW SEQUENCES WILL BE EXCHANGED WITH THE CANADIANS AND MADE AVAILABLE, AS QUICKLY AS POSSIBLE (WITHIN A FEW MONTHS), TO UNIVERSITY AND INDUSTRIAL LABORATORIES WORKING ON ARCHAEAL HYPERTHERMOPHILES AND THERMOSTABLE GENE PRODUCTS. IN PARTICULAR, THEY WILL BE MADE AVAILABLE TO OTHER LABORATORIES WORKING ON EU CELL FACTORY PROGRAMS CONCERNED WITH THERMOPHILIC ORGANISMS. WE PLAN TO COMPLETE THE S. SOLFATARICUS GENOME, WHICH IS OF CONSIDERABLE INTEREST TO INDUSTRY BECAUSE OF THE THERMOSTABLE NATURE OF ALL ITS ENZ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Breaking the barrier - An integrated multidisciplinary approach to kill Gram-negative bacteria through existing antibiotics by making their outer membrane permeable'.

assistant: **Concept**

Antimicrobial resistance, which is caused by multi-drug-resistant bacterial pathogens is a global health emergency. Gram-negative bacteria (GNB) notably hinder effective treatment because of their impermeable outer membrane (OM). Consequently, many standard-of-care (SOC) antibiotics cannot access intracellular targets in GNB. The objective of the BREAKthrough European Training Network (ETN) is to sensitise GNB to these antibiotics by making their OM permeable. To this end, we will develop inhibitors of three protein machineries that are responsible for OM maintenance. Importantly, many known antibacterial agents have characteristics different from drugs that are directed against targets in mammalian cells. To define better rules for antibacterial drug development a data hub will be created to assemble information on the physico-chemical characteristics of molecules that can pass the OM.To achieve these goals, a multi-disciplinary academic-industrial consortium has been assembled with organic chemists, computational chemists and specialists in high-throughput drug screening, zebrafish infection models, bacterial morphogenesis and the molecular biology of the three targets. The expected outcomes of the BREAKthrough ETN include (i) the development of new chemical space rules for drugs that need to cross the OM, (ii) the discovery of new inhibitors that interfere with OM maintenance to overcome the insensitivity of  Gram-negative pathogenic bacteria towards SOC antibiotics and (iii) providing 10 Early Stage Researchers with scientific, technical, business and transferable skills to become professional drug developers with a keen eye for the hurdles in the development of these drugs in an industrial context.


**Keywords:** Bacterial outer membrane, Gram-negative bacteria, B
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Shape Coexistence and Collectivity in Atomic Nuclei' (SPEDE).

assistant: **Concept**

In the atomic nucleus, the interplay between single-particle motion, collectivity and pairing is seen as a rich tapestry of coexisting nuclear shapes and exotic excitations. For verifying and more detailed understanding of the shape coexistence phenomenon it is important to measure transition probabilities between the coexisting nuclear states.In the endeavour to understand the nuclear structure and related interesting phenomena, in-beam gamma-ray and electron spectrometers have been important tools. However, a gamma-ray or an electron spectrometer alone can provide only partial information of nuclear de-excitation processes. Moreover, electron spectroscopy with radioactive ion beams (RIBS), with very few exceptions, has not been exploited at all.The research objectives of the present proposal are:1) Initiate an electron spectroscopy campaign by performing simultaneous in-beam conversion electron-gamma-ray spectroscopy in the Accelerator Laboratory of University of Jyväskylä (JYFL).2) Develop similar techniques for complementary experiments, for the first time, with RIBS at REX-ISOLDE (and for future HIE-ISOLDE).The scientific aim of the present proposal is to extend the studies of shape coexistence in exotic nuclei by employing novel methods of in-beam conversion electron spectroscopy to investigations of electric monopole transitions (E0) and other highly converted transitions. Such studies have been carried out for nuclei close to the stability line but so far only very few attempts have been made for exotic nuclei close to the drip lines, especially when employing RIBs.The proposed project will be carried out at JYFL and provides a step towards a professional researcher and enables to diversify the physics interests of the Fellow. He will manage a large internationa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Phenogenomics of sirtuin corepressor family', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

By modulating the activity of transcription factors, cofactors influence cellular and organismal metabolic pathways. Recently the role of the sirtuin cofactor gene family received a lot of attention in this context, as their beneficial impact on longevity was linked to effects on metabolic control. Most sirtuins catalyze deacetylation reactions that are tightly linked to cellular energy (NAD+) levels. To ascertain the tissue-specific contributions of sirtuins in metabolism, we propose here to: 1) identify novel deacetylation targets for the sirtuins; 2) generate and characterize genetically engineered mouse models (GEMMs) with somatic mutations in the 7 sirtuin genes in liver, muscle and adipose tissue, key metabolic tissues; 3) study mouse models with natural genetic variation in sirtuin expression, such as found in genetic reference populations (GRPs), like the BxD recombinant inbred mouse lines; and 4) validate the relevance of sirtuin signaling for human metabolism through clinical genetic studies. As the goal is to progress towards the treatment and prevention of metabolic diseases in humans, GEMMs are optimized to study the actions of isolated genetic loci and are thus insufficient to characterize polygenic networks and genetic interactions. Moreover environmental factors can impact on the manifestations of the genotype or phenocopy the genetically produced phenotype. Thus, to dissect complex genetic traits, experimental models, like GRPs, that imitate the genetic structure of human populations provide complimentary information to that obtained from GEMMs. As we will combine data generated using directional genetic strategies in GEMMs with a high-throughput phenogenomic analysis of GRPs, our approach merges the benefits of clear-cut results of single gene perturba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dark Matter and Stars in the Dark Ages' to be submitted under Seventh Framework.

assistant: **Abstract**

The possibility that the first stars in the universe may be powered by dark matter annihilation rather than nuclear fusion has been recently proposed in the literature. This intriguing phenomenology defines a new field, in which particle dark matter properties affect the characteristics of astrophysical populations in the young universe. In DAMiDA we propose a thorough approach to the problem: stellar evolution in the presence of dark matter annihilation, the survival of these stars through the evolution of the first galaxies, the nature and impact of the feedback of these objects on the formation and evolution of subsequent structures will all be addressed with different techniques. The final aim is to provide links between dark matter properties and astrophysical observables of high redshift. This will allow the particle and astro physics communities to either use forthcoming astrophysical data, provided by means of planned observational campaigns to constrain the nature of elusive dark matter, and particle experiments aimed to study the nature of dark matter to shed light on the high redshift universe.