RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Operation Condor: Accountability for Transnational Crimes in Uruguay' (2014-2020).

assistant: **Innovation**

Confronting past atrocities is essential to consolidate democracy and human rights protection. Truth and justice initiatives investigating crimes perpetrated at the national level have long been occurring. Yet, accountability for transnational crimes is a pending issue in scholarship and practice. This project fills this gap and addresses the transnational dimension of past atrocities in South America. In 1975, the dictatorships of Argentina, Bolivia, Brazil, Chile, Paraguay, and Uruguay established a secret transnational network of intelligence and counterinsurgency operations to persecute political opponents in exile called Operation Condor, kidnapping and murdering hundreds of people. The project aims to study transnational crimes, by focusing on Operation Condor’s Uruguayan victims, and probe the response of Uruguay’s national justice system to transnational atrocities. Uruguay was selected to analyse Operation Condor: one Uruguayan was kidnapped in each Condor country; thus, investigating its Uruguayan victims permits to also study the entire network and its modus operandi. The project creatively adopts a regional focus and uses data from recently opened archives. The broader question behind the research agenda is: how can we respond to atrocities that transcend state borders? Studying accountability for Operation Condor crimes will offer lessons of potential application to past and present forms of transnational crimes, such as the smuggling of migrants across the Mediterranean Sea. The outputs include three articles, a book, a policy brief, op-eds, a workshop for legal professionals, seminar and conference presentations, and training sessions for PhD students and early career researchers. The Fellowship will directly benefit Dr Lessa’s career prospects, equipping
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Structure of a large non-crystalline multiprotein assembly by solid-state nuclear magnetic resonance with ultra-fast magic-angle spinning' (COMPLEX-fastMAS-NMR) targeting Horizon 2020.

assistant: **Abstract**

Extrapolating from protein structure to function is an operation difficult to accomplish, as most functions in the cell are not carried out by single proteins, but by macromolecular complexes containing multiple subunits endowed with specific functions. Despite the many advances in structural and biochemical studies of isolated molecules, a comprehensive portrait of cell biochemistry must thus include insights of the supramolecular network of interactions among the individual constituents. The structure determination of large and dynamical protein ensembles presents a great deal of challenges for X-ray diffraction techniques, and for solution nuclear magnetic resonance (NMR) due to the large size of these objects. Consequently, there is little information available today on the overall organization of the assembly subunits, their interactions, and sometimes their precise function within the cell. High-resolution solid-state NMR (ssNMR) has recently developed as a powerful structural tool for studying structure and dynamics of solid biological samples at atomic resolution. A number of issues remain however to be addressed before ssNMR is ready to cope with large-sized multi-domain functional assemblies.The proposed project aims to capitalize on new concepts recently introduced by the host institution, to implement innovative solid-state NMR methodologies. Sophisticated experimental approaches will be introduced at high magnetic field, in combination with ultra-fast magic angle spinning (MAS), enabling the structure characterization of non-crystalline assemblies that cannot be currently carried out by any other experimental technique, and notably, the determination at atomic level of the structural details that govern protein-protein interactions in functional assemblies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanism of action of enzymes requiring pyridoxal phosphate' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The coenzyme pyridoxal phosphate mediates in the catalysis of metabolic reactions of D- and L- amino acids. Although much work has been done on the mechanism of action and stereospecificity of these processes, it has been difficult to examine the intermediate stages because the substrates are processed so effectively. We therefore propose to synthesise stereospecifically labelled inhibitors of these enzymes and use them to study the overall mechanism of action of the reactions. This will involve isolation of enzyme-inhibitor complexes and trapping of enamine intermediates with thiols. The stereospecificity of formation of the Snackertz intermediate will also be studied. The use of these inhibitors will allow intimate details of the mechanism to be studied. The involvement of D-amino acids in bacterial metabolic processes makes the enzyme inhibitors of potential value as anti-bacterial drugs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Intelligent modelling algorithms for general evaluation of toxicities' in the context of a Fifth Framework call.

assistant: **Objectives**

The training program is on environmental sciences, computer science, computational chemistry, in a multidisciplinary way. A common training will be with periodic short courses on specific areas of the project. Two workshops will be organized on the project. Trainees will actively participate to the project meetings, every six months, and will present their work. Young researchers will be solicited to participate to conferences and congresses. Young researchers will be given informal individual training, by specialists in the field, on the use of the specific software, techniques and methodologies. Young researchers will be able to attend under- and post-graduate lecture courses within universities of the consortium. In particular at the Liverpool John Moorses University courses will be in English. The Scholl of Pharmacy and Chemistry and the University will allow the student to run a full scheme of half and full day courses on various aspects of research techniques and management. For the training trainees will visit at least a second laboratory, beside the laboratory which will make the training.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Internet of Radio Light', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Wireless networks in buildings suffer from congestion, interference, security and safety concerns, restricted propagation and poor in-door location accuracy. The Internet of Radio-Light (IoRL) project develops a safer, more secure, customizable and intelligent building network that reliably delivers increased throughput (greater than 10Gbps) from access points pervasively located within buildings, whilst minimizing interference and harmful EM exposure and providing location accuracy of less than 10 cm. It thereby shows how to solve the problem of broadband wireless access in buildings and promotes the establishment of a global standard in ITU. Building landlords will be incentivized to find funding to realize this solution for their properties to increase their value resulting in a stimulated market for broadband networking products in buildings, benefiting society and stimulating the world Gross Domestic Product. IoRL project provides solutions to the two main barriers to develop this broadband networking solution in buildings because it: (i) Brings together a multi-disciplinary team of research institutions and industries in a collaborative project to develop and demonstrate this vision, who otherwise would not have assembled to achieve this goal; (ii) Develops a proof of concept demonstrator, which will act as the basis for standardization of a global solution. The starting point is the joint VLC demonstrator at Tsinghua University & ISEP, the mmWave at Cobham Wireless and the NFV/SDN at NCSR-Democratos. The challenges are to (i) Develop broadband communication solutions for buildings by integrating these technologies to exploit the pervasiveness and accessibility of the existing electric light access points, the broadband capacities of mmWave and VLC technologies an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ECO-FRIENDLY AND BREAKTHROUGH MITE TREATMENT FOR HONEY BEES' in the context of a Horizon 2020 call.

assistant: **Objectives**

Currently, honeybee mortality rates range from 5% to almost 30% depending on the country and the year, being some of the main causes the Varroa mite. This parasite is currently treated with chemicals, which are considered a necessary evil by a population of beekeepers that considers chemical treatments largely as a threat because themselves are a cause for the bees’ population decline. In view of these problems, other alternatives have been researched for decades, being the hyperthermia the methodology with highest potential to displace the use of chemicals. However, until now the current commercial solutions based on hyperthermia principles are not an alternative to chemical products due to a lower efficiency.Vatorex AG is an award winning Swiss company committed toproviding cost-efficient and eco-friendly solutions for beekeepers. The new business started in 2016 and provides beekeepers with an eco-friendly solution to protect their hives from their greatest enemy: the Varroa mite.We have developed an eco-friendly solution to kill the Varroa mites by using a natural principle of different heat tolerances of bees and varroa. In a range between 39°C - 42°C the parasite dies while the bees survive unharmed. In contrast to other hyperthermia systems, Vatorex Varroa Solution heats the brood combs directly from the inside thanks to a heating coil that acts like a floor-heating. Vatorex Varroa Solution has proven to be an effective treatment directly in the beehive (95% of male mites and nymphs die at 41ºC within 2 hours of treatment). The Vatorex-System means a reduction of sanitary cost of 66% per hive and a 18% in total cost of honey production that entails a total saving impact for the approximately 600,000 European beekeepers and their 17 million of hives. Vatorex is fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Polarization and its discontents: does rising economic inequality undermine the foundations of liberal societies?'.

assistant: **Innovation**

The project will examine the relationship between economic inequality and societal openness, one of the foundational elements of liberal society. Specifically, the project will provide new empirical evidence on the purportedly negative relationship between inequality and social mobility, support for democracy, and social cohesion in the West. The challenge addressed by the project is foremost empirical: for each dimension of openness, there are straightforward theoretical arguments to link rising inequality with declining openness. In each case, there is widely-known evidence to support a negative relationship in bivariate cross-sectional cross-country data. In each case, however, the best available research has regularly failed to confirm the negative relationships in longitudinal designs that sought to identify the causal impact from within-country changes in inequality. To possibly reconcile the discrepancies, the project will create four new multilevel databases that combine survey microdata across more than 30 countries and over observation windows possibly extending back to the 1970s to gain leverage for an encompassing and stringently longitudinal empirical analysis. The newly constructed databases will be used for a detailed decomposition of inequality trends, a disaggregated description of trends in social mobility, social cohesion and support for democratic governance, and for a differentiated causal analysis of the role of economic inequality for societal openness in the West. The latter rests on suitable multilevel regression specifications that distinguish between mechanical, power- and composition-dependent mechanisms and that involve temporal lags, effect thresholds, systematic treatment effect heterogeneity, and appropriate controls for concomitant trend
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'GAbapentin in Paediatric Pain' under Seventh Framework.

assistant: **Concept**

Chronic pain is estimated to affect 15-20% of children with varying disabilities. Due to the paucity of clinical information and appropriate medicinal products, in clinical practice paediatric patients are often under-treated causing profound impact on their QoL.To date, opioids, non-steroid anti-inflammatory drugs (NSAIDs), antidepressants and anticonvulsants are used to treat pain, but only few of these include a paediatric authorisation. In addition, the few available paediatric drugs have a very different authorisation profile across Europe and, when not approved in paediatrics, they are used off-label to cover the high therapeutic need, thus exposing children to unnecessary risks of dosing errors and increasing ADRs.The GAPP Project is focused on the development of gabapentin for the treatment of paediatric chronic pain, a condition where gabapentin, as demonstrated in adults, is expected to bring great benefit to children.To this end, a large international scientific Consortium is set up, with experienced professionals in the field of pain that will work together with a Pharmaceutical Company committed to apply for a PUMA using the project results.Within GAPP, age-appropriate formulation will be developed and two randomised, comparator-controlled clinical trials and a bridging study will be conducted in compliance to a submitted Paediatric Investigation Plan (PIP, Summary Report Day 90 - EMEA-001310-PIP01-12) in order to investigate appropriate dosages, efficacy and safety of gabapentin in the paediatric population. Further to this, in order to ensure the safety of gabapentin in very young children, a non clinical study will be conducted to evaluate the neurotoxic potentil of the drug. At the end of the project, gabapentin can be proposed for treatment of chronic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Road mapping, Research Coordination and Policy activities supporting Future Internet-based Enterprise Innovation'.

assistant: **Concept**

FutureEnterprise aims at aims at boosting Digital Business Innovation by supporting and coordinating the research activities in Future Internet from the perspective and for the benefit of enterprises. Combining an open innovation approach with Web 2.0 tools, FutureEnterprise will fully align the scope of its activities to the priorities of DG CONNECT Unit E3: Net Innovation.In FutureEnterprise, bridging research with entrepreneurship plays a pivotal role, which is driven by the consolidation of research / educational material and its provision as digital innovation elements / entrepreneurship 'seeds'. With regard to the roadmapping activities, FutureEnterprise will deliver iterative and live versions of a research roadmap on new forms of enterprises. Taking into account the transition to new EU-funded programmes, FutureEnterprise will also provide concrete recommendations for policy makers and the EC, to accelerate the emergence of new forms of enterprises.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of a cell marker to trace lineages and detect gene expression in vivo in the peripheral nervous system of drosophila' to be submitted under Fourth Framework.

assistant: **Abstract**

Enhancer-trap lines are genetic tools in which a reporter gene, not normally found in Drosophila, is expressed under the same control as a normal fly gene. The most frequently used reporter gene is lacZ, the product of which can only be visualised in fixed tissue. The aim of my project is to develop a system where the expression of the reporter gene can be followed in living tissue. This I will achieve by using the Green Fluorescent Protein (GFP) which is autofluorescent and can therefore be detected in living cells.  I will take advantage of the existence of trap lines where the reporter gene is GAL4, a yeast transcriptional regulator that activates any gene flanked by a UAS sequence, to drive the expression of GFP in the appropriate cell types. This system will be used to solve crucial questions related to the lineage and differentiation of nerve cells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of Diversity on tropical forest bioMass dynamics: effects of disturbance and biogeography' (DivMass).

assistant: **Concept**

The importance of biodiversity in supporting ecosystem functioning, especially biomass productivity, has motivated numerous research questions. However, controversial results have been found so far while testing a direct link between diversity metrics and biomass, an approach that discards the fact that biomass is a composition of three other variables: number of stems, wood density and mean aboveground volume. It is only possible to access the role of diversity on biomass by separating the components of AGB, since diversity operates through different (and non-exclusive) ecological mechanisms that act separately on different AGB components: the selection effect (SE) and the complementarity effect (CE). The SE (or “sampling effect”) emerge as a result of a hyper-diverse community having a greater chance of containing particularly productive species, while the CE states that plant communities consisting of multiple species that coevolved to occupy different environmental niches can partition limited resources more efficiently, thus providing greater biomass compared to that expected from monocultures. This proposal aims at developing a new conceptual framework that will help test 1) how diversity drives variation in biomass and productivity through different ecological mechanisms acting on specific components of biomass; 2) whether historical disturbances influence the current effect of diversity on biomass and biomass productivity and; 3) whether the effect of diversity on biomass and biomass productivity differ among the Neotropics, Afrotropics and Asian tropical forests. These objectives will be achieved via i) disaggregating AGB in wood density, stem density and mean aboveground volume components and ii) separating the effect of SE and CE to assess the effects of dive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unravelling White Matter Biological Heterogeneity for the Prediction of AD' under Horizon Europe.

assistant: **Concept**

White matter (WM) is being increasingly studied in Alzheimer’s disease (AD) as a possible key pathological driver. In-vivo, WM health can be measured through several metrics derived from diffusion weighted imaging (DWI). While these metrics provide information about the WM micro- and macro-structural alterations, the biological processes determining such changes is often unclear. Characterizing these biological pathways is crucial for a more refined use of MRI in the clinics and for building accurate disease models for individualized prediction. In this work, we will use several cohorts covering the AD spectrum with both available MRI and biological data (genetics, proteomics). We will first perform a characterization of the biological pathways that provoke WM dysfunction in different stages of AD. Subsequently, we will use this information to build data-driven models of disease progression and spreading. Finally, we will test the applicability of these models in data from memory clinics.


**Keywords:** multi-omics, white matter, diffusion imaging, biomarkers, disease modeling