RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Molecular mechanims of mRNA transport in neurons' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

RNA transport coupled to local translation presents an efficient means to regulate gene expression in time and space. Recent studies have indicated that this mode of post-transcriptional regulation is used in many different cell types and applied to hundreds to thousands of transcripts. mRNA transport is of particular importance in neurons, where it is involved in processes such as axon guidance and activity-induced synaptic plasticity. Loss of proteins involved in regulating RNA transport have been linked to hereditary mental retardation and dendritic targeting of certain mRNAs has been shown to be crucial for formation of long-term memories. However, which mRNAs are differentially localized in neurons and by what mechanism they are transported remains largely unknown.Here we propose to investigate this problem using the model organism Drosophila melanogaster, which offers significant experimental advantages, such as little genetic redundancy, powerful tools for loss- and gain-of-function studies and the possibility of visualize living neurons in their natural environment at high resolution. Furthermore, previous work has established that the overall mechanism of RNA transport is conserved from fly to humans. Thus, findings in the fly system are likely to have direct implications for our understanding of the human brain.We will adapt an established live cell imaging approach to identify mRNAs that are specifically enriched in neuronal processes. Identified transcripts will be characterized in further detail and used to search for RNA-binding proteins that specifically contact their localization elements. Candidate proteins will be tested for a role in mRNA transport using genetics coupled to high resolution imaging. Eventually, proteins regulating mRNA localization wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Energy transduction in KInetically asymmetric catalytic NETworks' (KI-NET) under Horizon Europe.

assistant: **Objectives**

Endergonic processes are central to Life. They are achieved by enzymes, that change conformation during their catalytic cycle. Thus, biological non-equilibrium processes are catalysis-driven. The realization of catalysis-driven processes in artificial systems proved challenging. It remains limited to synthetically demanding interlocked structures, which were upgraded with catalytic features affecting ring sliding motion.With KI-NET, I want to develop a general biomimetic strategy enabling endergonic processes driven by chemical catalysis. I plan to invert the current approach by introducing defined conformational freedom into simple catalytic units.KI-NET scientific objectives go beyond state of the art in chemically-driven non-equilibrium systems, with the aim to:(i) establish an unconventional theoretical approach based on “effective transition states”, that guides experiments and reveals common underlying principles for catalysis-driven processes and chemical oscillations;(ii) realize endergonic conformation changes powered by catalytic processes, including ATP hydrolysis;(iii) promote endergonic assembly reactions, that will reveal how energy consumption directs chemical adaptation;(iv) realize an artificial synthase: a catalyst that harvests energy from one reaction and uses it to drive a different one.I will implement a theory-guided experimental approach at the interface between systems chemistry and molecular machines. Leveraging my broad chemistry background, I will address questions that expand towards physics – in terms of formalizing models – and biology – in terms of operating systems to be imitated and unraveled.Realizing KI-NET allows overcoming thermodynamic boundaries. Unforeseen opportunities become possible in material science and energy management, s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Algorithmic and Mathematical Cryptology' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Cryptology is a foundation of information security in the digital world. Today's internet is protected by a form of cryptography based on complexity theoretic hardness assumptions.  Ideally, they should be strong to ensure security and versatile to offer a wide range of functionalities and allow efficient implementations.  However, these assumptions are largely untested and internet security could be built on sand.The main ambition of Almacrypt is to remedy this issue by challenging the assumptions through an advanced algorithmic analysis.In particular, this proposal questions the two pillars of public-key encryption: factoring and discrete logarithms.  Recently, the PI contributed to show that in some cases, the discrete logarithm problem is considerably weaker than previously assumed.  A main objective is to ponder the security of other cases of the discrete logarithm problem, including elliptic curves, and of factoring. We will study the generalization of the recent techniques and search for new algorithmic options with comparable or better efficiency.We will also study hardness assumptions based on codes and subset-sum, two candidates for post-quantum cryptography. We will consider the applicability of recent algorithmic and mathematical techniques to the resolution of the corresponding putative hard problems, refine the analysis of the algorithms and design new algorithm tools.Cryptology is not limited to the above assumptions: other hard problems have been proposed to aim at post-quantum security and/or to offer extra functionalities. Should the security of these other assumptions become critical, they would be added to Almacrypt's scope. They could also serve to demonstrate other applications of our algorithmic progress.In addition to its scientific goal, Almacry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Prediction of the Effects of Radiation FOr reactor pressure vessel and in-core Materials using multi-scale modelling - 60 years foreseen plant lifetime' (2007-2013).

assistant: **Concept**

In nuclear power plants, materials may undergo degradation due to severe irradiation conditions that may limit their operational life. Utilities that operate these reactors need to quantify the ageing and the potential degradations of some essential structures of the power plant to ensure safe and reliable plant operation. So far, the material databases needed to take account of these degradations in the design and safe operation of installations mainly rely on long-term irradiation programs in test reactors as well as on mechanical or corrosion testing in specialized hot cells. Continuous progress in the physical understanding of the phenomena involved in irradiation damage and continuous progress in computer sciences have now made possible the development of multi-scale numerical tools able to simulate the effects of irradiation on materials microstructure. A first step towards this goal has been successfully reached through the development of the RPV-2 and Toughness Module numerical tools by the scientific community created around the FP6 PERFECT project. Relying on the existing PERFECT Roadmap, the proposed 4 year Collaborative Project PERFORM 60 has mainly for objective to develop multi-scale tools aimed at predicting the combined effects of irradiation and corrosion on internals (austenitic stainless steels) and also to improve existing ones on RPV (bainitic steels). PERFORM 60 will be based on two technical sub-projects i) RPV and ii) Internals. The Users' Group and Training sub-project shall allow representatives of constructors, utilities, research organizations... from Europe, USA and Japan to receive the information and training to get their own appraisal on limits and potentialities of the developed tools. An important effort will be made to teach young rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ClimateJusticeReady' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Cities in the Global North are increasingly adopting nature-centered and other green infrastructure interventions to respond to climate risks and impacts and enhance their adaptation and resilience capacity. Yet, plans for such green infrastructure (GI) and other urban greening interventions tend to underestimate risks of displacement for lower-income and minority residents – what myself and others have previously called green climate gentrification. Despite increasing recognition of this process and concerns for the displaced, few municipal green interventions are coupled with social provisions (such as social housing; resident-driven economic development schemes) to protect residents from displacement. Yet, predicting and preventing green gentrification is the only way to build a green resilience agenda that upholds the stated social and environmental goals of such plans and avoid green paradoxes born out of urban renaturing projects and which municipalities have expressed commitment to avoid. In this POC, I propose to further analyze the social equity impacts of climate adaptation and green resilience efforts and build on my GreenLULUs ERC in order to (a) create a replicable, interactive community- and policy-driven predictor index, tool, and analysis for green gentrification in the context of planned green climate-centered infrastructure and (b) test the early development of an actionable, pilot municipal policy and planning instrument, such as a climate-adaptation focused community land trust, a municipal green bond program for equitable climate resilience, a community-based stewardship fund, or green minority-owned green business seed grants (among others) to prevent green climate gentrification. These tasks will be decided and built in partnership with municipal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Commercialising MR-HIFU: an Image-Guided Local Drug-Delivery Platform' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Reducing the high attrition rates in drug development continues to be a key challenge for the pharmaceutical industry. With average drug development costs of over $2 billion dollar and a 95% failure rate of cancer drugs in Phase I trials, a new paradigm is highly needed.iGOLDD represents a unique opportunity for the commercialisation of a powerful alternative drug-delivery solution that has the potential to locally boost the efficacy of many drugs for a range of clinical indications. Prof. Moonen and his team, as part of the ERC project Sound Pharma, have developed a powerful technology platform, based on magnetic resonance guided focused ultrasound (MR-HIFU), that can be used for high-precision image-guided drug delivery, HIFU is the only known technique capable of completely non-invasive, precisely controlled heating deep inside the human body. MRI allows continuous imaging of the tumour and surrounding health tissue for target definition. iGOLDD aims to commercialise this unique technology as a stand-alone drug delivery platform that can be widely offered to pharmaceutical and biotechnology companies to improve new or existing drugs or reuse shelved therapies. In iGOLDD we will further optimise the HIFU technology (in particular temperature control and motion correction) for drug delivery of macromolecular drugs, such as antibody-drug conjugates, to demonstrate the large potential of our drug delivery platform. In addition, we will prepare for market introduction, by defining the exact business strategy, model and positioning for commercial success. We will develop the business strategy that offers the most promise, based on the technological aspects of the project, the market needs and trends, the end-user needs and the IP-position. During this project, we will gain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Demonstration of ANemometry InstrumEnt based on LAser'.

assistant: **Concept**

The availability of highly integrated laser and optics technology offer the prospect of increased aircraft Air Data System robustness in adverse conditions. Indeed, although critical, the system is subject to hailstone, icing, corrosion, bird collision, passenger stairs mishandling. Thus the optics technology offers the capability to improve the operational capacity and safety of the air transport system.  DANIELA aims to carry out research and development as well as technology maturity improvement to prepare the installation on new airliners of a fully non intrusive Optical Air Data System (OADS). Thus DANIELA will: - validate the capability of the system to measure the parameters in all flight conditions : DANIELA will address the main issues coming from the use of signal back scattering instead of well known pressure measures. Atmosphere particle dissemination studies will be performed, and  OADS system will be evaluated in a worst case ie high altitude un polar conditions. - investigate and mature dedicated technology : improvement in laser sources and optical functions integration glasses are the key technology to reach commercial air transport requirements and insure an European source for optical ADS, along with dedicated signal processing schemes.  Resistance of side mounted OADS glasses to dust, ice or sand as well as any atmospheric erosion will be evaluated during representative test in wind tunnel. - evaluate new temperature measurement principle that allow replacement of the intrusive TAT probe.  Future generation airliner studies have already set the main driver for a competitive aircraft. DANIELA aims to push integration a step beyond NESLIE demonstrator to fully validate the OADS concept with regards to future commercial air transport needs.  The output
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Classification of Olive Oils and Detection of Adulteration' (CODA) targeting Sixth Framework.

assistant: **Abstract**

This project aims to investigate the effect of olive cultivar, olive growing location, harvest year and the processing on the characteristics of olive oils and to develop methods to detect the adulteration of oils. Fatty acid composition, infrared spectra, total phenol content, phenol profile, per cent free fatty acids, oxidative stability and colour of the oils that will be obtained from six varieties of olives grown in the same grove in Izmir region will be determined. To determine the effect of location, characteristics of oils from Izmir region will be compared with oils from Edremit region. Differences/similarities between the composition of commercial and self-extracted oils will provide information about the effect of processing. Using multivariate statistical analysis techniques, oils will be classified according to factors stated above.Data obtained for the classification of oils will also form a database for the adulteration detection studies. Using the determined characteristics of oils, rapid methods will be developed for the detection of adulteration of mono-varietal oils with other olive oil types and other edible oils. This study is concerned with a product quite important for European agriculture and, as the number one consumer and exporter of t his product, the project will be valuable both from economic and product quality of points for EU.Researcher of this proposal involved in similar projects during her post-doctoral appointment in Purdue University of USA and would like to apply her experience and knowledge she acquired during these studies into proposed project. She would like to continue her studies with classification and detection of adulteration for wine. Izmir Institute of Technology could provide researcher all the necessary means for the su
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identification of genomic and biological markers as predictive/diagnostic/therapeutic tools for use in allogeneic stem cell transplantation: translational research towards individualised patient medicine' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Allogeneic stem cell transplantation (HSCT) is a life saving therapy for haematological disorders (leukaemia and lymphoma, inherited immune disorders, and aplastic anaemia). Over 7000 such transplants are carried out each year in Europe. However the over all survival rate after HSCT is poor (40-60%), and cure of patients is hampered by clinical complications that arise post-transplant; largely due to genetic and biological differences which exist between a given patient and donor. These differences includ e transplantation antigens (major and minor histocompatibility antigens). Pioneering research by Partners, have indicated that a number of non-HLA gene polymorphisms also affect the severity and incidence of transplant related complications. There is an urgent need to improve patient-donor matching at both the biological and genomic level which would develop HSCT beyond the current state of the art. HSCT outcomes will be improved if predictive assays, diagnostic tools and new therapeutics were developed and ultimately used by HSCT clinicians for individual patient based medicine. TRANS-NET teams have expertise in predictive bioassays, genomics, diagnostics and novel therapeutics who will train researchers in the key technologies of, mRNA expression profi ling, pathology, non-HLA immunogenetics and mechanisms of immune recognition; with the ultimate aim of applying the results of TRANS-NET in the HSCT clinical setting. TRANS-NET aims to 1) Define new biological/genomic indicators and novel therapies for th e potential development of new clinical strategies for improving the outcome and quality of life of HSCT patients. 2) Develop unique training programmes in genomics and immunobiology of transplantation and generate highly trained scientists with the abili ty to manage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Laser fields', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The aim of this proposal is to request support for two EuroConferences devoted to new advances in the study of the interaction of matter with extremely intense laser light. Indeed, the recent development of powerful femtosecond lasers makes it now possible to achieve enormous intensities, of the order of 10, 19 W/cm². In these conditions, the electric field of light is stronger than that present inside the atoms and causes the electrons to move at velocities very close to the speed of light. This leads to a variety of new phenomena, many of which are not yet well understood. The technology is evolving rapidly and new experiments are being performed, creating a need for a new and deeper theoretical interpretation. European research is holding the world leadership in this fast growing area of research.