RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Breast Cancer Biomarker Point of CarePOCDiagnostic Platform Integrating Dual-Functionalized Nanoparticle for Magnetic Gradient Ranking and Electrochemical Sensing' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Breast cancer is the most common neoplasm in women and the second leading cause of cancer-related mortality in females worldwide, with 25.1% of incidence and 14.7% of mortality across all cancers. A convenient blood-based tumor marker test has the potential to underpin a significant improvement in early intervention.In this context, this proposal is concerned with development of a new point of care (POC) device for biomarker detection by exploiting a combination of state of the art magnetophoresis, electroanalysis, nanotechnology, and microfluidic integration. In the POC device, dual-functionalized magnetic nanoparticles (dual-NPs) with antibodies and redox probes will be capable of selectively recruiting specific markers from real patient samples and will additionally underpin amplified redox probes for detection. Second, using a magnetic gradient chip, composed of both magnetic gradient (Mag) and microelectrode (Me) arrays, the exerted magnetic gradient field will be capable of separating dual-NPs labeling biomarkers (MBs) from free dual-NPs (MPs) to be positioned at distinct sensing zone of micro-electrode, prior to assay. Herein, only those biomarkers hosted by dual-NPs, will be reported electrochemically for quantification.Three primary objectives are proposed by the candidate: i) development of dual-NPs combining immunological recognition and electrochemical amplification properties, ii) fabrication of Mag chip engineering Mag and Me arrays for magnetic gradient ranking and electrochemical sensing, iii) integration of POC platform with Mag and Me arrays, dual-NPs and microchannels, for cancer biomarker diagnosis.As a proof-of-concept, the developed POC device will be applied to the detection and quantification of breast cancer markers (CA15-3, PAI-1 and HSP90A) in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Potentials of Agroecological practices in east Africa with a focus on Circular water-energy-nutrient systems' under Horizon Europe.

assistant: **Concept**

PrAEctiCe will provide a novel agro-ecology indicator set for East Africa, aimed at helping smallholder farmers in their agro-ecological transition. The project goes beyond the existing indicator frameworks by putting the “concept into action” with a decision support tool for agro-ecology advisors supporting the selection of the best suited combination of agro-ecological practices in a local context. In addition, it puts a focus on circular water-energy-nutrient systems of integrated aqua-agriculture, an practice with high potential for efficient farming with minimal climate impacts, which has not been sufficiently explored in previous indicator work. Through a multi-stakeholder approach, new insight on agro-ecological practices in East Africa will be gathered to inform on existing successful practices as well as the barriers and drivers of East African smallholder farmers. This insight will help develop an indicator framework for agro-ecology, which, while building on existing frameworks, is adapted to the East African context and captures integrated aqua-agriculture practices in detail. The PrAEctiCe decision support tool will then, at the farm level, help assess environmental and socio-economic impacts, with a particular focus on impacts on climate change mitigation and adaptation as well as financial viability. The tool will be validated in three living labs, situated in Kenya, Uganda and Tanzania, covering different integrated aqua-agriculture farming set-ups. Knowledge sharing activities through trainings, student exchanges and events, ensure the dissemination of results across East Africa and between AU and EU. To reach practitioners at every level, a cascade training mechanism with a train-the-trainer course will help agro-ecology advisors train farming represen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Regulation and modulation of the NALCN channelosome' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The sodium leak channel (NALCN) is the ion-channel subunit of the NALCN channelosome, additionally containing UNC79, UNC80 and Fam155. NALCN controls the resting membrane potential (RMP) in excitable tissue (e.g. brain and myometrium) by an inward current of positively charged (sodium) ions that depolarizes the cell membrane, sensitizing the cell to excite (activate). NALCN is essential for survival. Mutations in the NALCN channelosome cause loss- or gain of function of NALCN currents which result in severe developmental disorders IHPRF and CLIFAHDD. Yet, NALCN channelosome physiology is largely unknown and no selective or specific drug-like compounds targeting the NALCN channelosome exist.I propose the objectives: I) to characterize regulation of the NALCN channelosome by endogenous protein partner interactions (PPIs), and II) to identify and characterize de novo designer proteins that modulate NALCN function. I anticipate that this can inform on NALCN physiology and future therapeutic strategies to counteract NALCN loss- or gain of function and other excitability-related disorders.I will perform the research at Copenhagen University in the lab of Professor Stephan Pless, an expert in the field. Objective I-II build onto novel in silico approaches where the Pless lab has identified PPIs based on protein co-evolution, tissue-co-expression, and disease association; and generated de novo designer proteins designed to bind the NALCN channelosome. I will elucidate the objectives experimentally by utilizing – and expanding – my experience in ion-channel research. In Objective I, I will use i) electrophysiology to study the functional impact of PPIs, ii) immunocytochemistry to interrogate sub-cellular localization and trafficking, and iii) biochemistry to determine direct int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A novel bone implant with enhanced bone healing capacity'.

assistant: **Innovation**

The objective of the project is to bring the first bone implant with enhanced bone healing capacity to the market and clinical practice. The market demand for bone implants is steadily increasing driven by aging populations, increased demand for high quality of life and an increasing number of joint reconstruction surgeries. Enhancement of the bone healing process is often necessary, especially for patients with larger bone voids and gaps. The existing clinical methods targeting this need are based on the combination of Bone Graft Substitutes (BGS) with:• systemic treatment with Bone Active Drug (BAD), or • the off-label use of the BAD. Both alternatives create risks for side-effects and complications. BONESUPPORT will move beyond the current state of the art and propose CERAMENT-BC – the first product combining a BGS with a BAD (bisphosphonate), enhancing the healing capacity of the implant. The commercial potential of this nano-modified material lies in the efficient local delivery of the drug to the targeted skeletal side, minimizing side-effects and improving quality of life for the patient. The targeted users are orthopedic surgeons who need new methods for the enhancement of the bone healing process, reduction of secondary fractures and postoperative complications. CERAMENT-BC will meet those needs by combining the advantages of BGS and BAD and thus providing both fracture stability and a local therapeutic effect.The Phase 1 study will develop a business plan for the commercialisation of the product. Assuring cost-efficient and innovative approaches to the treatment of musculoskeletal conditions is an EU-wide challenge. The project will address this challenge by proposing a new treatment option which for the first time combines an injectable biomaterial with a BAD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of strategy and application of molecular tools to assess biodiversity in chicken genetic resources' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The overall goal of the project is to experimentally evaluate strategic questions relating to the assessment of Biodiversity in the chicken using molecular information that can be measured in various ways at the DNA level. In the proposed project we will examine the level of point mutations between and within chicken populations. This will be relevant as a criterion to assess Biodiversity, and at the same time it will provide the background to adopt a completely new technology of DNA chips in poultry populations. Microsatellites are currently widely accepted as the most powerful tool to characterise Biodiversity at the molecular level. By collecting large samples from various breeds we will establish a complex genetic distance matrix to quantify Biodiversity in chickens based on microsatellites. Although theoretical studies have been carried out, questions related to the sampling strategy, number of markers and statistical analysis need still to be answered experimentally and will be approached in the proposed project. The project will deepen our understanding of Biodiversity not only in chickens, but also in comparative aspects by extending molecular studies of Biodiversity within Non-mammalian species. The major objectives addressed in the project are as follows: 1) To assess Biodiversity in a wide range of 50 chicken breeds using a set of 25 microsatellites and DNA pools of 50 individuals per breed for genotyping. This information will give insight in the currently existing Biodiversity in chickens, and by including commercial lines, to what extent they compare to unimproved local breeds and the Red Jungle fowl (Gallus gallus), the progenitor of all chickens. Gene mapping studies using microsatellites are already well established in the chicken. Some Participants of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Fibre Reinforced Concrete with Recycled and Waste Materials Optimised for Improved Sustainability of Urban Projects'.

assistant: **Objectives**

Reinforced doncrete urban infrastructure poses significant, insufficiently addressed, environmental challenges due to impacts from cement, natural aggregate and steel reinforcement production. This proposal focuses on integrating fibre reinforced concrete (FRC) with “green” concretes produced with waste and recycled materials. The large scatter of current FRC characterisation tests leads to conservative structural design and the incomplete understanding of waste and recycled materials’ effects on “green” concrete properties leads to quality control challenges. As a result, existing standards and design codes are not comprehensive and the market uptake of these concretes is low. This action proposes a synergy of FRC and “green” concretes to achieve fully sustainable urban infrastructure. The action will develop and optimise structural-grade “green” FRC (G-FRC) with different recycled and waste materials for maximising sustainability; develop novel G-FRC characterisation tests with reduced result scatter; formulate performance-based indicators for recycled and waste materials used in G-FRC to facilitate quality control; and develop design guidelines for G-FRC structures with full-scale structural test verification and in-situ application, within 24 months of project duration. The expertise of the experienced researcher (ER), Dr. Nikola Tošić, and the supervisor, Dr. Alberto de la Fuente Antequera, are fully complementary and will enable them to develop novel research techniques through a two-way knowledge transfer and comprehensive training activities for the ER. The project will engage Smart Engineering Ltd for industrial application of project results. Comprehensive dissemination and communication measures focusing on different target audiences are formulated. A careful
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Investigating the regulation of the senescence-associated secretory phenotype (SASP) by mitochondrial DNA (mtDNA) metabolism for the development of novel senotherapies.'.

assistant: **Concept**

In response to various stresses such as DNA damage, telomere erosion, or oncogene activation, human cells can enter senescence. This process is characterized by irreversible proliferative arrest, deep transcriptional reprogramming, and expression of a collection of inflammatory factors termed the SASP (senescence-associated secretory phenotype). As it limits the proliferation of cells potentially bearing neoplastic potential, the triggering of cellular senescence is an essential tumor suppressing mechanism. However, the persistence and accumulation of senescent cells in aging and pathological contexts can have deleterious effects, particularly due to the SASP. It is thus fundamental to understand the basic physiology of senescent cells to develop so-called senomorphic drugs that modulate SASP expression. Changes in mitochondrial physiology elicited during cellular senescence onset strongly suggest that the maintenance and integrity of their mitochondrial DNA (mtDNA) may be altered. For instance, cytosolic leakage of mtDNA has been shown to take place in senescent cells and participate in SASP expression via immune pathways activation, but the contribution of mtDNA metabolism and replication in SASP expression has not yet been explored. My preliminary results show that mtDNA copy number increases continuously during senescence progression, accompanied by recomposing of the mitochondrial replisome. I also showed that this increase in mtDNA copy number promotes SASP expression. In the present project, I will characterize in details the alterations in mtDNA maintenance and integrity during senescence; profile the evolution of mitochondrial replisome composition; and characterize how the previous regulate SASP expression. The perspective of this project is to identify new se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'INTERNATIONAL RESOURCE PANEL (IRP) SECRETARIAT' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The International Resource Panel (IRP) was launched by the European Commission and set up in cooperation with the United Nations Environment Programme (UNEP) in 2007, at the request of Member States. Its objective is to provide scientific knowledge on the issues related to sustainable resource management so that policy makers use that knowledge to inform decision-making. The IRP addresses the topics of resource efficiency, management of raw materials and decoupling economic growth from environmental degradation. It will build a roadmap for defining a safe operating space for resource use and projecting scenarios for resource use. It will also aim at better understanding how to prevent unintended negative consequences from resource efficiency on societies.The Panel is a science-policy interface that serves as a platform for exchange between eminent scientists from around the world and the policy community. As such, it provides the scientific experts with an insight into the knowledge needs of policy makers, while providing policy makers and other stakeholders with the best available scientific knowledge on resource related issues as a basis for developing sustainable development policies. In order to achieve its objectives, the IRP will:- Publish independent, coherent and authoritative scientific assessments of policy relevance on resource use and related environmental impacts developed and made available to policymakers and other relevant stakeholders. - Communicate findings of IRP scientific assessments effectively to policymakers and other relevant stakeholders in order to improve awareness and understanding of the importance of resources for sustainable development and poverty reduction, as well as for meeting all the Sustainable development Goals (SDGs).- Conduct ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Performant Alternative to Nickel-based alloys for Turbine of Helicopter Engine Replacement' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The work presented in this proposal will help the topic leader to evaluate the ability of an innovating TiAl material to replace nickel-based super-alloys for low-pressure turbine application. The PANTHER project will focus on the investigation of the resistance of TiAl alloy under high strain rate, high temperature and different stress triaxiality levels. A combined approach between numerical simulations and original experiments will help creating a reliable transient dynamics material model for behaviour and failure. An upstream methodology will be applied, aiming at testing the material from a microscopic scale to a structure scale. The work will begin by numerical simulation of a blade-off in order to evaluate the important parameters to take into consideration in the model. The results of this preliminary study will drive the experimental conditions for the material testing on Split Hopkinson Bar apparatus. A first couple of parameters will be fitted thanks to this first test campaign. The study will go on with simplified impact testing (two impact configuration) with highly instrumented targets. These tests will reveal the behaviour and failure mode of the TiAl under dynamic conditions. Numerical simulations of these experiments will be performed and material model parameters will be adjusted to correlate simulation results to experimental ones. The goal of the last testing campaign (three impact configurations) is to reproduce the real events that can occur during the life operation of an engine turbine. A last batch of numerical simulation will allow to confirm the ability of the established material model to accurately predict such complex events. The call is in THIOT’s core business and strategy. With the PANTHER project, THIOT is submitting an innovating prop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Large Scale Machine Learning for Simultaneous Heterogeneous Tasks'.

assistant: **Concept**

The topic of this research is robust machine learning in the face of many conflicting tasks and objectives the agent is responsible for learning. As learning algorithms become a more important component of future systems, the flexibility required for these algorithms to address the ever-increasing range and complexity of tasks we ask of them will require advancements in machinelearning techniques. It is the view of the researcher that one very important aspect of this advancement will be the development of techniques that can handle an order of magnitude or more greater concurrent tasks without requiring undue effort on the part of human programmers or unreasonable computation time or computational burden. This work will develop more flexible learning mechanisms that can allow for the degree of autonomy that will be necessary in the nextgeneration of learning systems. In particular, improvements are necessary in life-long learning behavior of agents that are intended to address a wider range of problems than most current systems are capable of, and such systems need to be able to concurrently manage many more goals and tasks than they currently do, and do so with less direct human intervention. In particular, this research focuses on the problems inherent in agents which must maintain the goal oflearning very many heterogeneous tasks simultaneously. These problems primarily lie in scaling the learning algorithms, in more intelligent management of action selection to ensure that the agent is able to balance the conflicting goals without ignoring any of the tasks. The research proposes to address the problems by adapting current research from the field of multi-objective optimization tohelp develop new scalable reinforcement learning algorithms. In addition, new algorithm