RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Evolution  and  ecology of Bacillus anthracis: the transition from a soil organism to a mammalian pathogen' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Despite their importance, little is known about the origins of many emerging human pathogens and the way that invertebrates could shaped their evolution. Bacillus anthracis, the causative agent of anthrax, is closely related to the important insect associated pathogens B. cereus and B. thuringiensis. In B. anthracis, it has been proposed that the horizontal acquisition of the mammalian virulence regulon atxA created a dynamic tension with the insect virulence regulon plcR, which resulted in the functional inactivation of PlcR. The isolate of B. cereus G9241 caused an illness resembling inhalational anthrax and possesses functional versions of atxA and plcR. We hypothesize that this strain represents an early stage isolate recently derived from an insect pathogen in which the competition of the atxA and plcR regulons has yet to resolved. In this proposal we will address the contribution of AtxA and PlcR to gene regulation and virulence in this emerging B. anthracis-like strain. We will develop insect, soil amoeba and mammalian macrophage infection models and use these to compare the B. cereus type strain ATCC14579, B. anthracis Sterne and B. cereus G9241. Furthermore, we will directly address the impact of AtxA upon B. cereus G9241 by means of competition assays with a knockout mutant atxA and monitor reporter gene expression in the mutant and the parent strain in both insect and mammalian tissue culture conditions. Finally, we will conduct micro evolution studies by repeated challenge through the M. sexta host to elucidate the selection pressure acting on the competing AtxA and PlcR regulons in invertebrate infections. A deeper understanding of the molecular biology of B. anthracis virulence could afford novel strategies for future treatments or vaccination against anth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'IMPROVING PLC PROGRAMMING THROUGH A NEW GRAPHICAL, OBJECT-ORIENTED AND BRAND- INDEPENDENT PROGRAMMING FRAMEWORK'.

assistant: **Objectives**

Most Modern automation installations are driven by Programmable Logic Controllers (PLCs). Nowadays, the low level programming languages that have been used for decades, such as Ladder Diagrams (LD), are still being used to develop the new software. Besides, there are ‘hidden’ penalties: PLC software is brand dependent. The solution to this problem has been the adoption of new paradigms that allow for a fast and reliable software development. One of the most productive of such paradigms, which has been worldwide adopted, is the Object Oriented (OO) paradigm. The aim of the project is to develop a software tool which for developing PLC programs with the following features: • Based on the Object Oriented approach, but using an industrial model for the design of the components that constitute a PLC programs. • Extensible. The design of the objects includes built-in capabilities for performing not only their specific task, but also for exchanging data with external supervision programs (SCADAs), databases (SQL), etc. • Graphical Interface. • Integration of existing tools. Every object block can be internally programmed in one of the low level language supported by the IEC-61131-3 norm. • Library maintenance tools for an easy storage and retrieval of developed objects. • Brand independence. A brand-specific postprocessor generates the final code ready for downloading into the target PLC. Therefore the PLC-PROG software sets a new framework easing PLC programming. This new tool will provide an easy overall view of the PLC based automation process, providing a high level automation language easy to use and to understand, reducing drastically the time devote for PLC programming and to built up the subsequent ECBs. As the project solves a general Industrial need, the project has
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Filling ‘empty’ landscapes, mapping the archaeological continuum' under Seventh Framework.

assistant: **Concept**

The research proposal envisages a two-year interdisciplinary program designed to stimulate changes in the way in which archaeologists in Italy in particular but also more generally in the Mediterranean world study the archaeology of landscapes, moving from an essentially site-based approach to a truly landscape-scale perspective. The aim is to help in the development and wider application of new paradigms for landscape analysis based on the integration between ‘traditional’ approaches, multidisciplinary studies and new technologies in the form of large-scale geophysical survey and the collection and analysis of high-resolution LiDAR data.The geographical focus of the project will lie for the most part in central Italy (Tuscany and Lazio) where the candidate has been working on two sample areas. The objectives of the Marie Curie project can be summarized as follows:1.To place the experience so far gained in Italy in a broader European and Mediterranean context through the review of information about relevant case studies elsewhere on the Continent and in the UK.2.To continue and expand the fieldwork in central Italy, mainly filling gaps so as to achieve a more continuous picture of the areas under study by improving the size of the samples.3.To confront and hopefully fill the gap between palaeo-environmental history and anthropic evidence by introducing environmental studies in the Italian context.4.To focus on archaeological analysis and GIS-based interpretation in a multi-scale landscape context.5.To improve understanding through the application of new technologies with particular regards to:a. Evaluating the influence on changing historical patterns across time.b. Improving understanding of the likely returns from different methodologies.c. Improving planning and cons
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Importance of  human β and Endothelial cell Cooperation for the maturation, organisation and functionality of islet organoids.' under Horizon Europe.

assistant: **Concept**

To cure diabetes, functional ß cell mass must be restored. Transplantation of human islets has seen significant progress over the past decades. However, organ donor shortage is a major obstacle. For transplanted patients, poor graft revascularisation and a recurrent autoimmune attack ultimately result in the loss of the graft. Human induced pluripotent stem cell (iPSC)-derived ß cells are a promising alternative source of cells that is inexhaustible and allows genetic interventions prior to transplantation to stimulate revascularisation, immunoprotection and ultimately graft survival. iPSC-ß cells retain an immature phenotype in vitro and only in vivo acquire mature function equivalent to that of native human islets. Intra-islet endothelial cells (ECs) form a necessary niche for pancreatic endocrinogenesis and adult ß-cell function, and they improve islet survival after transplantation. This proposal aims to test the hypothesis that ECs are crucial to generate mature and functional human iPSC-derived islet organoids in vitro and to promote revascularisation, function, adaptation to metabolic challenges and survival in vivo. To this end, we will generate 'vascularised' islet organoids containing iPSC-derived endocrine and ECs. By combining genetic interventions and cutting-edge technologies, such as whole tissue three-dimensional analysis and transcriptomics, we will characterise the impact of ECs on islet organoids. This project will broaden the knowledge on the essential relationship linking structure to function in human islet organoids, paving the way for new human cell therapies.


**Keywords:** beta cell, endothelial cell, human induced pluripotent stem cell, three-dimensional analysis, transcriptomics, adaptation to pregnancy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advancing Synthethic Supramolecular chemical biology' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Many supramolecular systems have been inspired by nature, but the number of supramolecular systems that are truly functional in water at the low concentrations required for biomolecular studies are very limited. Cucurbiturils are one of a few select supramolecular systems that show great promise for the modulation of protein assemblies in biologically relevant media, but they require better means to control homo- and heterodimerization. In order to effect strong and selective heterodimerization I will design and synthesize a wide range of complementary guest pairs, using chemical and electronic concepts such as π-π stacking and electronic donor−acceptor pairs. After testing these on the cucurbituril host-guest system, they will be assessed on heterodimeric protein assemblies such as split luciferase. As many biological processes require multimeric protein assemblies, I will develop novel supramolecular constructs to gain control over the formation of such assemblies. By constructing protein-coupled cucurbiturils and developing novel double cucurbituril systems, trimeric and tetrameric protein assemblies will be assessable. Development of these advanced supramolecular tools is crucial in order to access synthetic signaling platforms with potential for molecular diagnostics.


**Keywords:** Chemical Biology, Cucurbituril host-guest chemistry, Protein assembly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Characterization of Salmonella enterica hydrogenase-5 biosynthesis for developing novel anti-infective compounds', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Recently, the discovery of new antibiotics has slowed, while the incidences of infections caused by bacteria that have become resistant to commonly used antibiotics are rising. There is therefore a growing clinical need for innovative approaches to developing novel anti-infective compounds. Hydrogen is an important energy substrate for a number of pathogenic bacteria and H2 oxidation is essential for the virulence of Salmonella enterica serovar Typhimurium. S. enterica expresses three different H2-uptake [NiFe]-hydrogenases and one of these (termed hydrogenase-5) belongs to a novel class of O2-tolerant hydrogenases that is synthesized aerobically and oxidizes H2 in the presence of O2. The Hyd-5 gene cluster encodes two accessory proteins, HydH and HydG, that are absent in anaerobic systems and are conserved in those systems in which hydrogenases are synthesized in the presence of oxygen. In other systems, HydH homologs have been proposed as scaffolding proteins that bind the immature [NiFe] cofactor prior its transfer to the large subunit of the enzyme. HydG-like proteins are hypothesised to assemble or stabilize the Fe-S clusters of small subunit during biosyntheis. This proposal aims to study the functional role of accessory proteins HydH and HydG in the biosynthesis of Hyd-5 and to design novel small molecule compounds that potentially inhibit hydrogenase activity and assembly. Understanding the mechanisms involved in the biosynthesis of Hyd-5 will allow the development of hydrogenase inhibitors and, as consequence, anti-infectives of virulence of Salmonella and other bacterial pathogens. This project addresses a key biomedical challenge and establishes [NiFe] hydrogenases as novel and credible drug targets.


**Keywords:** [NiFe]-hydrogenase, oxygen tolerance, Salmo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Aladin training network' (ALADIN-NET) under Fifth Framework.

assistant: **Objectives**

The ALADIN project, through its Toulouse central place, has already an excellent track record in training of foreign visitors: 5 completed PhDs and 4 on their way and at least 16 person x years of training through shorter stays during the eight years of existence of the common effort. The financial support asked through this proposal would permit to offer PhD and post-Doc positions on the following topics: non-hydrostatic modeling of the atmospheric flow, diabetic forcing at small scales (when both resolved" and "parameterized" computations mix their effects), coupling of global models with limited area ones, use of the optimal control formalism to assimilate at the finest possible scales remote sensed data about clouds and rainfall, noise control in both model runs and data assimilation procedures. None of this topic, taken individually, is likely to be the vector for a complete breakthrough in atmospheric science. But, like always in the "NWP industry", it is the combination of individual nice research steps that will make the quality of the service delivered by European NMSs to their citizen and/or clients."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'RESEARCHERS' NIGHT: PEOPLE FOR A BETTER FUTURE'.

assistant: **Innovation**

The RN13: People for a Better Future proposal consists in different activities which are deeply related. The first activity consists of ten main Events on the 27th September 2013, which will gather more than 25000 people, organised by nine public entities and two associations around Spain and a Science Museum. A second activity consists on a Drawing Competition, which will be performed before and after the 27th event. Also special emphasis will be done on the 2.0 tools which together with the Drawing Competition, will be used to disseminate 27th Event Activities. European Corner will be built in order to let the society know that Europe cares for Researchers, both physical and virtual.The main objective of the project is to enhance the recognition of researchers and their role in society, showing that Researchers are among us. The latest economic cuts do not help to improve the image of Science and Scientist; on the other hand, they make people think that one can do with no Research and Researchers. It is necessary to show the society that with No Researchers there is No Future. For this purpose, Researcher will be participating in Researcher’ Night activities to show the importance of Scientists in the current economic context. The Communicative facet of researchers together with some hands-on experiments will be used to bring them closer to the large public enhancing public recognition of Researchers and their Work, as well as convincing young people to embark on scientific careers.The Events will be implemented using two different activities:1. Drawing Competition: Based on previous experiences of the Researchers’ Night edition, a drawing competition will be held. The analysis of drawings will be used to tackle the existing stereotypes about researchers.2. RN13: Peop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Coordination and support actions' (PROSME-INN).

assistant: **Innovation**

PROSME services in RO3 region regarding SME Instrument support will ensure the delivery of “Key Account Management” (KAM) support services, enhance innovation management capacity and processes of SMEs, developand test PROSME partners capacities for consultancy services.


**Keywords:** SME, innovation management, KAM, EEN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Photons in two-dimensional photonic microstructures in optical wavelengths' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content We propose a systematic investigation of the luminescence behaviour of photonic microstructures in optical wavelengths over a wide range of material systems. The work will consist in the realisation and characterisation of microstructures in three lattice geometries, triangular, graphite" and "boron nitride", in III-V and Il-VI materials, both with air holes in semiconductor and pillars of semiconductor in air. The samples will be patterned by electron beam lithography and dry-etching. Surface treatments after dry-etching, such as sulphide passivation or anodic oxidation will be investigated in order to improve the quality of the microstructures. Another challenge will be to increase the depth of etching in the microstructures and hardened silicon nitride could be used as a more robust mask instead of silica. Finally we shall introduce defects in the photonic structure. The samples will be characterised by several different methods including high resolution scanning electron microscopy, photoreflectance, photoluminescence and waveguide transmission experiments. We expect to see major effects on spontaneous emission produced by photonic microstructures. The impact of a defect on the transmission will be the possibility to obtain one emission mode allowed in the bandgap. This phenomenon is of great importance for laser and very narrow band filter applications of photonic microstructures . Training content (objective, benefit and expected impact) - use of electron beam lithography and reactive ion etching and special requirements for the design of photonic microstructures: regularity of small (about 100nm in diameter), closely packed features. - investigation of different materials with different behaviour - high technology advantageous to t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Nas complement to contract no: g1rd-2001-00490'.

assistant: **Innovation**

SmartWeld will develop East European welding innovation with West European science, QA and power plant expertise. A consortium of manufacturers and utilities will develop new consumables for creep resisting steels, designed to refurbish old polluting plant in Eastern Europe, improving environmental standards and carbon dioxide emissions. Performance will be validated by microstructural modelling and advanced high temperature testing. SmartWeld will develop smart" consumables which match the steel to be welded, make joints with lower stresses, and produce welds with better reliability. Analysis will demonstrate the promise of trouble-free plant operation, saving inspection and repair costs. Procedures will be developed for manufacture, repair and welding onto service aged steels. Implementation will include plant refurbishment, manufacture of new lightweight components, code certification and commercialisation."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Manufacturing, engineering and service status electronically negotiated for greatly enhanced response' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

MESSENGER will deliver advanced electronic communication of information between manufacturing organisations and their service networks, including extended enterprises and non-affiliated SME agents. An XML and XSL migration from EDI, an XML defined relational database meta language, an XML information processor, an intelligent search mechanism, a 3D/multimedia extranet, MPEG-4 compression, and LDMS radio transmission with WAP protocols, will be developed to transmit engineering data, including full technical manuals plus updates, to the service network and to receive back spares orders, consumer guarantee claims, product/service complaints and fault/repair information. This feedback will be routed for co-operative engineering to design, manufacturing and accounts departments, providing a mechanism for tracking actions to correct the situation for future deliveries by improved production processes and/or redesign, with management accounting for costs of problems and solutions.