RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Role of PPARgamma in the interstitial fluid volume regulation and contribution to cardiovascular complications of TZDs' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Thiazolidinediones (TZDs) are clinically proven insulin sensitizers with anti-inflammatory benefits used in the therapy of type 2 diabetes mellitus (T2DM) and atherosclerosis. TZDs can activate a transcription factor, the peroxisome proliferator-activated receptor gamma (PPARg). PPARg regulates expression of several genes involved in inflammatory pathways, lipid transport and carbohydrate metabolism. Antidiabetic effects of TZDs have been coupled to macrophages, since tissue macrophages can produce inflammatory mediators which can reduce insulin sensitivity leading to T2DM and its cardiovascular complications. Administration of TZDs spreaded rapidly recently, although serious secondary effects as fluid retention and ischemic heart disease have questioned the clear benefits of non-selective PPAR activation by TZDs in the medication of T2DM and related disorders. Kidney PPAR positively regulates sodium and water resorbtion, therefore TZD-induced fluid retention can be due to the activation of PPARγ in the kidney collecting ducts. Fluid retention can lead to backward heart failure, therefore we think that kidney PPAR is the origin of unwanted cardiac TZD effects. To test this novel hypothesis we propose a cross-disciplinary research project involving molecular genetics, in vivo imaging, and gene engineered animal models targeting the molecular mechanisms behind the cardiovascular complications of TZDs. We will determine also the contribution of tissue specific PPAR mutations to water retention and ischemic heart disease. Molecular mechanisms behind T2DM and its cardiovascular complications are among the most important and timeliness research areas in Europe, due to the growing T2DM prevalence. Understanding TZD side effects will contribute to new treatment strategies o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Grid Interoperability Project', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Grid computing is an important technology that will allow users and organisations to access computers, data, programs, or scientific instruments in innovative ways. It will open also new business opportunities. Within different application domains distinct Grid implementations have been developed based on both published open standards and on community specific features. Different grids will continue to exist to meet technical or organisational demands. GRIP will develop interoperability software for UNICORE and Globus and demonstrate the feasibility to exploit the specific strength of each implementation, the seamless user interface of UNICORE and the protocol focus of Globus. Biomolecular and meteorological applications will be used as inter-grid examples in GRIP. Project resources will be dedicated to standards work in the Global Grid Forum.OBJECTIVESThe ultimate purpose of Grid computing is to empower users and organisations to work effectively in an information-rich environment. Distinct Grid implementations exist. GRIP will demonstrate that the different perspectives of two distinct grids can successfully complement each other using Globus and EUROGRID as examples. The specific objectives of this project are:1. to develop software to facilitate the interoperation of UNICORE and Globus combining the unique strength of each system;2. to build and demonstrate biomolecular and meteorological inter-grid applications;3. to contribute to and influence international Grid standards. Together the three objectives will lead to proliferation of grids, global support for E-Science, faster advances in Grid development through sharing of solutions, and wider acceptance of grid technology by industry based on proven standards.DESCRIPTION OF WORKThe project is structured into five
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Weather Extremes: Assessment of impacts on Transport Systems and Hazards for European Regions' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The WEATHER project aims at adding to the current state of knowledge on the impacts of extreme weather events on economy and society in total and on European transport systems in particular. The project starts from the broad picture of climate scenarios and breaks them down to specific regions. Economic growth models are applied to study the impacts on economy and society and the inter-relations between transport and other sectors. The vulnerability of transport is assessed mode by mode including infrastructures, operations and intermodal issues. Best practices in emergency management are identified by studying the numerous damage cases world wide and options for adapting to more frequent and / or more extreme weather events are assessed.  A particular focal point of the project is to quantify expected damage, emergency and adaptation costs and the benefits of improved emergency management and adaptation. Moreover, the project will identify policy options to implement the recommended measures and demonstrate the competitive potential and the innovation power of a European lead market for adaptation and emergency management technologies and policies. The toolbox of the project consists of literature review, targeted interviews, workshops, cost accounting models and case studies. The project will last for 27 months. The team consists of 8 leading transportation research institutes all having well founded experience in the core research fields of the WEATHER project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A disruptive software solution guiding users to available parking spots and making interactionwith the parking infrastructure quick and easy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The task of locating a parking space in busy city centres is not only costly in terms of personal time for the driver, but also in terms of environmental impact (GHG emissions) and traffic creation (30% of inner city traffic in European cities attributed to parking search). The solution of parking garages is so far unattractive to the public, keeping parking space utilization as low as 50%.Evopark proposes a disruptive solution to simplify the procedure of finding available parking spots in busy and crowded inner cities, which comprises of: a mobile device software application, which informs the user in real time about parking availability in parking garages in the vicinity, an RFID vehicle identification tag, automating the process of entering, paying and exiting the garage, as well as the Evopark server storing vehicle and parking availability data from all the affiliated garages. The solution integrates perfectly with the existing Parking Management Systems (PMSs)-systems that handle visitor access, ticketing, track the visitor stream and provide data- most European garages are using.The solution impacts users (inner city drivers), creating savings on time and fuel by eliminating the need for parking search and simplifying parking garage utilisation. Evopark will also create a more sustainable and friendly urban environment: 40% less greenhouse emissions, less traffic congestion and noise, more liveable streets and more free spaces. For customers-garages and retail shops- it represents a new channel for user acquisition and retention, while optimizing the exploitation of free parking spots with no investment on infrastructure and no financial risk.The Phase 1 project will be focused on establishing a complete value chain, a sound business model and commercialization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'GALILEO Application Network' (GALILEAN) under Fifth Framework.

assistant: **Objectives**

GALILEAN is a 3 years Thematic Network, funded by the European Commission General Directorate INFormation SOciety (INFSO) and centred on GNSS applications.The ultimate objective of the GALILEAN thematic network is to support European manufacturers and service providers in increasing their share of the global satellite navigation.The GALILEAN thematic network will create an open dynamic network of organizations, companies and authorities with the general objective to:- Share data and information to increase the knowledge base on the GNSS system;- Create synergies and encourage standardisation in European research efforts related to GNSS Applications;- Encourage the creation of advanced services;- Increase acceptance of the satellite navigation industry and obtain stronger support from transport policy;- Increase the awareness and the attractiveness of GNSS towards all user groups;- Develop recommendations for industry, operators, administrations and policy makers.The intention of the network members is to provide a platform to discuss common problems, to communicate their know-how for future projects and to make recommendations that would enhance their business operations.The ultimate aim is to have an agreed but flexible roadmap for the promotion of GNSS applications in Europe, a roadmap that accommodates the requirements of the stakeholders in GNSS and takes into account the SME structure of the sector.The members of the network are representatives of the various organisations dealing with the issues of relevance to satellite navigation applications. Many are fully involved in the ongoing GNSS development and its associated projects. New members will be welcomed to join the network all along the GALILEAN contract duration. The funding available for the experts represen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Thinking Ahead: human planning from a predictive processing perspective' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Humans have an impressive ability to form action plans in several domains of cognition; for example, planning routes to goals in spatial navigation, or the necessary steps to assemble complex objects, alone or together with other persons. However, the computations that underlie human individual and social planning remain largely unknown. This proposal aims to explain the ways humans face three key forms of uncertainty arising in planning domains; namely, uncertainty about task structure, action sequences, and the contributions of self and others to cooperative plans. To this aim, it advances a radically new theory about human planning, within a Bayesian approach that has been successfully adopted to explain uncertainties arising in perception and control. The theory under scrutiny is that humans plan using probabilistic inference based on hierarchical predictive codes (HPCs): compressed information or task abstractions that afford a powerful form of uncertainty-minimization, by highlighting salient junction points of the problem at hand, analogous to saliency maps for visual search.The methodology will combine empirical and computational modeling methods, to systematically validate the hypotheses of HPC theory about human planning in the face of uncertainties.  A cornerstone of the methodology consists in conducting model-based analyses of human participants' behavior while they solve navigation-and-building tasks, alone or in dyads. This approach will permit us to compare the predictions stemming from HPC with those of alternative planning theories and ultimately, to understand the computations that underlie human planning.This ambitious proposal will produce groundbreaking advancements in our understanding of a high-level executive function - planning - while also con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Diversity and social interactions'.

assistant: **Innovation**

Social non-market interactions are important determinants of individual economic outcomes and welfare. Globalisation and the increased mobility of parts of the labour force as e.g. under the European common market raises interesting questions about the social costs and benefits of diversity. The project provides a novel and innovative perspective on the relationship between social interactions and diversity. Using game theoretic tools the proposed projects aims at developing and analysing models for the se lf-formation of groups, in the presence of informational spill-overs.Main research questions will focus on whether self-forming groups display too little or too much diversity from a social perspective, and its dependence on history i.e. pre-existing groups of interaction. A second part of the proposal aims at testing the theory in the lab, and applying policy treatments. To carry out the proposed project Martin Bøg will spend an academic year at the Stockholm School of Economics (SSE) under the mentoring of Professor Jorgen Weibull. SSE is considered among the top European departments and have expertise in the desired fields of the proposer.Martin Bøg is currently at the Department of Economics at University College London, as a post-doctoral research fellow at ELSE, the Centre for Economic Learning and Social Evolution. Martin Bøg expects to receive his Ph.D. ultimo January 2006 from University College London. He is currently undertaking research in a joint project with Professor Steffen Huck on the social dynamics of Internet fundraising. This project involves both applied econometrics and experimental economics, adding to the competencies of Martin Bøg.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Ion Flow in Microfluidics with Liquid Crystal Elastomer Actuators'.

assistant: **Concept**

Microfluidic devices consist of microscopic channels designed for precise fluid control. Their small size ensures laminar fluid flow, enabling the controlled transport of dissolved substances with applications in energy harvesting, desalination or even novel computing paradigms. However, the typical rigid network of channels greatly restricts their adaptability, and consequently, there is growing interest in developing time-evolving microfluidic systems, that can function as pumps, valves and mixing units. This requires a deeper understanding of fluid flows in dynamic environments and the development of stimuli-responsive materials for microfluidic walls. A highly promising approach involves the use of Liquid Crystal Elastomers (LCEs), which can change shape when stimulated. By incorporating LCEs into the walls of microfluidic devices, these systems can become responsive. The shape morphing can then be applied in microfluidic pumps and valves, two components required to achieve a fully integrated lab on a chip. I propose to pioneer the use of LCEs in responsive microfluidics and to deepen our understanding of the intricate non-linear dynamics between channel shape and conductivity. I will perform numerical simulations of the capabilities of LCEs in shape morphing microfluidic channels. I will then take the shape morphing channels and use the Lattice Boltzmann Method to simulate the transport of fluid and dissolved ions inside shape morphing channels. This will allow me to understand how to use LCEs in a microfluidic channel that, when stimulated, exhibits peristaltic motion or blocks the fluid flow. The project enables bidirectional knowledge transfer: the host’s expertise in liquid crystals will be instrumental for modeling LCEs, while my expertise in fluid dynamics wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Fluxes, Interactions and Environment at the Land-Ocean Boundary. Downscaling, Assimilation and Coupling'.

assistant: **Concept**

Coastal-zone oceanographic predictions seldom appraise the land discharge as a boundary condition. River fluxes are sometimes considered, but neglecting their 3D character, while the “distributed” continental run-off is not taken into consideration. Moreover, many coastal scale processes, particularly those relevant in geographically restricted domains (coasts with harbours or river mouth areas), are not well parameterized in present simulations. Because of this situation, local predictions still present significant errors and are not robust enough, even being locally wrong for sharp gradient events, such as flash flood discharges into the Mediterranean sea. This hampers decision-making in coastal zones. The FIELD_AC project aims at providing an improved operational service for coastal areas and to generate added value for shelf and regional scale predictions from GMES Marine Core Services. Local assimilation will be analysed together with advanced error metrics to provide a reliable service that can be transferred to public and private parties, using the spin-off company that will result from the project. This will be achieved by the introduction of more comprehensive “land” boundary conditions, improved local parameterizations and new coupling terms/strategies for the studied field cases. They cover a representative range of meteo-oceanographic drivers for four “geometrically” restricted domains (Catalan coast, Venice Gulf, Liverpool Bay and the Wadden Sea). FIELD_AC will bridge the gap from shelf predictions to local (river mouth or harbour/beach scales) simulations required at the coastal zone. This will result in a wider demand for operational services and an enhanced use of in-situ and remote observations. Such improvements (services and expertise) will require th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'The role of root-specific clavata1 homologues in regulation of cell differentiation within the arabidopsis root meristem'.

assistant: **Objectives**

Research objectives and content mechanisms of chlorine atoms, hydroxyl radical and nitrogen trioxide with a variety of fluorinetd ethers, which may be used as potential alternatives of fully halogenated hydrocarbons. Under tropospheric conditions, fluorinated ethers will react with hydroxyl radicals, mainly via the abstraction of a hydrogen atom. Preliminary investigations have also indicated that chlorine atoms are probably significant in the degradation of partially halogenated ethers, and proceed with a greater or even comparable rate than hydroxyl radicals. Therefore, the values of their rate constants have to be determined in order to evaluate the importance of these compounds with respect to ozone depletion and greenhouse warming effect. We propose to study the gas phase reactions of chlorine atoms, hydroxyl radicals and nitrogen trioxide with partially fluorinated ethers, CF2HOOCHF2, CF30CHF2, CF3CH20CH3, CF3CH20CHF2, CF3CF3CH20CH2CF3 and CHF2CF20CH=CH2, which are commercially available. They do not contain chlorine or bromine which could be released and enter the ozone destruction cycle. The degree of fluorination in these modules is expected to affect the rate and temperature dependence of their reactions with halogen atoms. The main concerns of the proposed study are the reaction rate with halogen atoms and its temperature dependence at ordinary temperatures (-20 - +100 c). The specific reactivity of substituted alkyl groups towards halogen atoms and its relationship with molecular structure will also be evaluated. The main objectives concerning the oxidation processes of partially fluorinated ethers are: 1. Determination of the reaction rate constants of Cl, OH, and NO3 with a series of fluorinated ethers in the gas phase over the temperature range 273-400 K.