RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrating Galileo and Copernicus downstream applications to support dynamic use of Public spaces' (Space4Cities) targeting Horizon Europe.

assistant: **Abstract**

SPACE4Cities will dynamise the uptake of space-based solutions for dynamic use and management of public space. This is an area of smart city development which is currently lagging behind in digital transformation when compared to parallel domains of similar economic and social importance. Cities are at the forefront of fighting today’s grand societal challenges, as they consume 75% of the natural resources, 78% of the world’s energy, produce 50% of the global waste, and emit 60-80% of the greenhouse gases. Yet, they account for less than 2% of the Earth’s surface. Therefore, SPACE4Cities project predominantly targets cities and densely populated regions.Cities face increasing pressure to tackle their climate challenges and to utilise their existing assets more efficiently, while at the same time be more agile in reacting to constant change from climate events and other factors. In effect, cities need to be more dynamic and more resilient. However, currently, cities are not able to manage their public space (on ground and in air) in an agile manner that would adequately support the increasing amount of different types of needs. If the management of areas is to become dynamic, it has to be based on dynamic data assets.This project strives for better, more dynamic management of public spaces, answering a concrete need for cities and regions to be able to adapt to fast-changing requirements for transport infrastructure, open spaces and city maintenance, and to increase their resilience to cope with extreme and disruptive events. Via smart exploitation of space data, the SPACE4Cities project aims to build replicable solutions for the dynamic management of public areas, and a clear roadmap for Europe-wide implementation of such space data-based solutions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Regulation and Function of Cullin-Ring E3 ubiquitin ligases and the Nedd8 ubiquitin-like protein modification system' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Cullin-RING E3 ubiquitin ligases (CRLs) are multi-subunit enzyme complexes that catalyze isopeptide bond formation between the C-terminal glycine residue of the small protein ubiquitin and lysine residues of substrate proteins (ubiquitination). Multiple rounds of ubiquitination lead to the formation of ubiquitin chains, which are recognized by the 26S-proteasome, a protease that degrades the substrates. Targeted protein degradation by CRLs is an important part of many essential cellular processes. Progression of the cell cycle, for example, requires CRL-dependent ubiquitination and degradation of cyclin-dependent kinase inhibitors (CKIs). Clearly, substrate ubiquitination needs to occur at the right time and place, and it is thus essential that CRL activity is tightly regulated. In fact, the malfunction of CRLs has been associated with many human diseases, including cancer. One mode of CRL regulation is the activation of the ligase by the small ubiquitin-like molecule Nedd8 (neddylation). Neddylation of the cullin triggers the formation of an active ligase complex and induces structural changes that allow efficient substrate ubiquitination. My proposal aims at gaining mechanistic insights into the activation and inactivation cycles of CRL complexes. I propose to study the regulation of cullin neddylation and the role of the newly identified Nedd8 E3 ligase Dcn1 in this process. I will identify new substrates of the Nedd8 pathway with yeast genetics and biochemistry and generate a systems-wide map of genetic interactions with CRL substrates and regulators using synthetic genetic array (SGA) analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'In silico trials for pulmonary drug delivery with breakthrough digital twins of the lungs'.

assistant: **Objectives**

Due to the limitedness of current technologies, the respiratory system has historically been a sort of black box in many aspects of R&D and clinical practice. At Ebenbuild we want to open this black box by building the first accurate, patient-specific simulation models of the lungs, the so-called digital twins of the lungs. In addition to patient data, these are based on first-of-a-kind predictive, physiologically accurate computational models of the respiratory system. By opening the black box for the very first time, our technology holds the potential to become the definitive source of health intelligence for respiratory diseases across a variety of use cases in healthcare and life sciences, from preclinical R&D to point-of-care. This will make Ebenbuild a deep-tech vanguard with a diversified spectrum of scalable products, each with a significant patient benefit and a global revenue potential and with our technological platform at their core.With EIC support we aim at expanding and validating the potential of our technology for provision of Twinhale tool to Biotech, MedTech and Pharma companies. Twinhale supports in-silico trials for pulmonary drug delivery and enables faster development of better inhalable treatments. Achieving this milestone will not only unlock an intriguing business opportunity, but will also be the starting point to further develop and eventually position our platform products along the entire spectrum of the medical value chain, from the inception of novel therapies to their application at the point-of-care.


**Keywords:** Digital twins; lungs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Promoting the integration of the gender dimension in basic research in ERA/FP7' (GENDERBASIC) targeting FP7.

assistant: **Abstract**

The objective of this activity is to ensure a better integration of the gender dimension in basic life sciences research. Integration of the gender dimension for life sciences and biomedical research consists of the consideration of both sex differences and differences resulting from gender. The activity of the proposed SSA specifically aims at supporting researchers in basic/preclinical research. The integration of the genderdimension, the expertise on the subject and awareness of the genderdimension still need improvement. Biological and socio-cultural differences between women and men may result in different epidemiological patterns and effect modification of diagnostic, preventive and therapeutic interventions. Above that researchers in the life s ciences encouter a variety of problems concerning gender issues in their research. It is our purpose to develop practical tools to help the researchers to tackle the problems. Already developed good practices will be collected and disseminated. When appr opriate, new tools will be developed. An expert meeting will be organised in which experts in basic life sciences research as well as methodological experts and gender experts will be challenged to present problems they encounter and their solutions to t he issue. During the expert meeting these presentations will be discussed on the basis of realism and proportionality. The experts will be asked to cooperate to develop tools that are suited for the everyday research practice and will meet the goals as f ormulated in the science and society call FP6.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Language on the move (LangMov): an investigation of Dâw motion categories in context' in the context of a Horizon Europe call.

assistant: **Objectives**

This project proposes a novel investigation of the concept of mobility among mobile hunter-gatherer groups through the lens of language. It will do so by examining verbs of motion  a bona fide linguistic category reflecting mobility  in indigenous lexicons and grammars. But what can verbs of motion tell us about hunter-gatherer mobility? And, how can occurrences of motion verbs map onto identifiable environmental and cultural features of a given society? Here, I explore these questions treating Dw (Naduhup; Northwest Amazonia) as a focal case. Dw is ideal for examining this topic because it harbors a rich system of motion verbs and a typologically unusual pattern of motion event encoding; it heavily encodes the notion of the terrain in the verb. I will conduct an innovative investigation into hunter-gatherer representations of motion as these unfold in the Dw peoples surroundings while speakers are on the move. While walking, semi-structured interviews will be performed in which speakers will be asked to describe what kind of motion they are performing. This will be recorded in audio, video and GPS for subsequent exploration of the motion verb usage and meanings in relation to measurable topographical features. A second layer of analysis will be provided by speakers posterior descriptions of the respective motion events. Multi-factorial analyses, bringing together measurable spatial manifestations and speakers perceptions of a motion event will result in a record of geographically mapped motion categories. Hence, I pursue the overall goal of substantially advancing our understanding of the linguistic encoding of motion in its language-and-culture-specific and motion-related context. This will both deepen our knowledge of the representation of mobility in a cultural cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Aabo akademi process chemistry training site'.

assistant: **Innovation**

Aabo Akademi University is located in the city of Turku, in the South-Western Finland at the Baltic Sea with a beautiful archipelago of some 60 000 islands. Turku is a university city of some 200.000 inhabitants and has excellent connections to both Helsinki and Stockholm. Aabo Akademi Process Chemistry Group, AA-PCG, is a National Centre of Excellence in Finland and a leading research centre in Europe in the area of chemistry oriented chemical engineering. The group consists of some 20 senior scientists and professors, some 30 Ph. D. students. The group is well equipped with modern laboratory reactors and instruments. The AA-PCG is studying physico-chemical processes in complex environments of industrial interest, this way aiming at finding novel solutions to industrial processes and products. This approach with the focus on detailed understanding of the process chemistry the group has named Molecular Process Technology. The group offers interesting opportunities in an international research environment with continuo collaboration with many leading industrial companies in Europe. The fellowships will be available within the following four research areas. Some on-going project activities are listed for each of the areas:Wood and Paper Making Chemistry (Identification and isolation of bioactive extractives from knot wood;Effects of wood polymers, lipophilic extractives and other impurities on paper quality and the runnability of the paper machine),Combustion and Materials Chemistry (Biomassfuel characterization for combustion applications;Modelling of furnaces for optimum design and operation based on computational fluid dynamics (CFD);Study of ash forming matter in fuels and fuel mixtures and their behaviour in advanced combustion systems;Development of bioactive glass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of variable stiffness seismic isolators and vibration mitigation dampers based on magnetically controlled elastomers' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Passive isolation systems available, suffer from certain limitations, the most important of which is the impossibility of varying their intrinsic characteristics to meet the demands of actual input types that are difficult to predict. The resulting poor performance is a problem particularly for certain strategic facilities, such as emergency centres and hospitals. Additionally, there are structures (such as tanks) having a varying mass, and thus needing an isolation system with the variable stiffness.The scope of the Project is to solve the above problems through the development of1) an improved smart elastomer whose stiffness is controlled by means of a magnetic field;2) semi-active seismic isolators able to maintain the specified degree of protection independently of the level of the seismic attack or changes in critical parameters;3 ) variable stiffness dampers for mitigation of ground-borne vibrations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ion Technology and Spectroscopy at Low Energy Ion Beam Facilities' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The Integrated Infrastructure Initiative ITS LEIF offers a platform for interdisciplinary research with high-quality low-energy ion beams. It is initiated by the Infrastructure Co-operation Network LEIF funded within FP5. ITS LEIF will combine the effort of 5 research infrastructures in 5 EU countries. 17 contractors and 14 user groups from 18 EU member states and associated countries will participate. It fosters mutual exchange of personnel and instrumentation to counteract fragmentation in this important multidisciplinary field.Research within ITS LEIF will mainly proceed at 5 infrastructures within a Transnational Access Activity, forming a Distributed European Facility. 4 Joint Research Activities (JRA1 - JRA4), which will improve and extend infrastructure performances by keeping their instrumentation at the cutting edge, will concentrate on the (i) development of sources and beams for complex ions, (ii) generation of low-energy, highly spatially and temporally resolved atomic ion beams, (iii) construction of electrostatic storage rings and traps, and (iv) production and characterisation of bio-molecular targets.Such developed methods and instruments shall be jointly demonstrated in specific research fields (JRA5 and JRA6) where significant developments are expected:(i) low-energy ion induced radiation damage in bio-molecular systems,(ii) antimicrobial ion coating of medical devices and ion-impact enhanced chemical reactivity, and(iii) low-energy ion induced nano-structuring of insulator surfaces and thin films.Cooperation will be strengthened by four network activities which interrelate the different projects, guarantee efficient internal and external communication, develop fruitful collaborations, disseminate the obtained knowledge, and develop joint strategies fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Civil society organizations and the politics of long-term care reform: coalitions and multiple inequalities' (AGenDA).

assistant: **Concept**

Population ageing and gender inequality are cross-cutting political and societal challenges facing Europe. AGenDA meets this challenges by implementing novel and interdisciplinary state-of the-art research on the interaction between multiple intersecting inequalities in Long-Term Care (LTC) reforms. It focuses on the impact of civil society organizations (CSOs) mobilizing around gender, age and disability in reform coalitions in Italy and Spain. Through research and public engagement, AGenDA’s strives to promote inclusive equality in LTC systems, thereby contributing to meet Horizon 2020 challenges “Health, demographic change and wellbeing” and “Inclusive, Innovative and Reflective societies”. By engaging civil society, it promotes participation and effectiveness of social actors in decision-making processes as highlighted in Europe 2020 strategy. By focusing on countries which are laggards in the development of LTC and gender equality policies, AGenDA produces and disseminates knowledge on the social and political obstacles that impede the development of fair and inclusive LTC systems, thereby strengthening integration and cohesion within the European Union. In line with MSCA objectives, AGenDA includes a comprehensive training plan to enhance the future career opportunities and inter-sectoral employability of the researcher. These objectives will be achieved through excellent training-through-research, an academic secondment developing new interdisciplinary and methodological competencies and a non-academic secondment providing access to policy networks and on-the-job-training in outreach and public engagement. The ambitious dissemination and communication plan aims at enhancing the international visibility of the project, promoting knowledge-transfer between all acto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Wound healing ILYA-style 2' (WHILYAS-2), addressing dissemination and exploitation.

assistant: **Impact**

ILYA PHARMA AB is a Swedish spin-out biotech company from Uppsala that develops next-generation biologics to treat wounds in skin and mucosa.In the previous SME Instrument project, the Company reached the First in Human (FiH) Phase I clinical trial in the development of their technology platform (ILP) that utilizes chemokines as therapeutic agents through local administration from genetically modified lactic acid bacteria.The WHILYAS-2 project addresses several critical problems and unmet medical needs related to the treatment of chronic wounds, both from patients and healthcare perspectives, namely the pandemic of obesity and diabetes (463 million people in 2019), an alarming pace of antibiotic resistance spreading (due to overuse of antibiotics), limited and insufficient treatment options (less than 25% of chronic wounds heal within 12 weeks), and vast and growing socio-economic burden (20 billion EUR per year in the US and Europe alone).The technical, industrial, legal, and commercial feasibility of ILP100 Topical have all been confirmed over the course of our previous activities and developments.In this project, Ilya Pharma intends to conduct exploratory clinical trials (Phase IIa) of their drug candidate, ILP100 Topical, in treatment of non-healing (chronic) wounds in populations with diabetes to achieve clinical Proof of Concept (PoC) in the relevant patient group. WHILYAS-2 will allow the Company to scale up and position it to be further investable for VCs and MedTech/Biopharma Companies or license ILP100 Topical to a partner capable of bringing it to the market through large-scale Phase IIb or pivotal (Phase III) clinical studies.If these efforts are successful, ILP100 Topical is expected to be superior and best in class treatment for chronic wounds, offering ea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Short sea shipping concerted action' (SSS-CA).

assistant: **Innovation**

1. Compilation of the State of the Art in Shortsea Shipping (SSS)2. Synthesis of all relevant research3. Definition of pilot projects and demonstrators4. Definition of criteria for SSS logistical efficiency5. Identification of key focal point for SSS future development6. Provision of dissemination of results %