RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'B Cell Engineering and Tertiary Lymphoid Structure Induction via Biomaterials for Cancer Immunotherapy' under Horizon Europe.

assistant: **Concept**

Recent clinical evidence points to a potential new direction in immuno-oncology: utilizing B cells and B cell-associated tertiary lymphoid structures (TLS). B cells display diverse immunological actions, including antibody production, antigen presentation, cytokine secretion and TLS induction. They have a dual role: they can initiate and reinforce anti-cancer immunity but B cells can also acquire regulatory phenotypes. To open up a new immunotherapeutic paradigm, I aim to understand how to optimally activate B cells, using nano-/biomaterials which load and precisely release a variety of agents to stimulate B cells and to suppress B cell regulatory phenotypes. Furthermore, I will manufacture porous scaffolds based on injectable microgels or via 3D printing with microgel fibers to induce TLS formation. The scaffolds with tunable porosity will allow B cells and other immune/stromal cells to infiltrate, arrange and expand, and soluble factors to diffuse. Moreover, the scaffolds can be easily functionalized with different chemical cues to stimulate B cells for TLS formation, such as CXC-chemokine ligand 13 and interleukin-7. This will help us understand TLS induction. Importantly, I will use ex vivo engineered TLS to study what microenvironmental factors influence their functionality. Subsequently, in vivo formation of B cell-associated TLS will be induced by the scaffolds. B cell activation and TLS induction will be combined for tumor therapy, and potential abscopal effect of the treatment to address metastases will be studied. The materials will be further combined with checkpoint inhibitors and chemotherapy to reach synergism. In addition, the new therapeutic strategies will be tested in patient-derived tumors established in humanized mice. BeaT-IT aims to understand opti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biased Agonism of GPR84 as a Novel Dual Anti-inflammatory and Pro-repair Mechanism' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Elevated local and systemic inflammation has been shown to play a central role in multiple diseases. An important cellular mechanism leading to chronic increased inflammation is dysregulation of the innate immune system. A drug that modulates macrophage function, suppressing the pro-inflammatory response while maintaining pro-repair function would represent a major breakthrough in the treatment of multiple degenerative diseases.Our host group very recently identified a biased agonist of an immunometabolic receptor, GPR84, which failed to induce chemotaxis (pro-inflammatory response) while stimulating phagocytosis (pro-repair response) in both murine and human macrophage (ACS Chem. Biol. 2019). This is an important discovery of a small molecule along with a defined molecular target and cellular mechanism which, for the first time, is capable of blocking a pro-inflammatory response while stimulating a pre-repair response in both mouse and human macrophage. These results are extremely exciting and demonstrate the translational potential of our approach, but the small molecule they identified, while a useful in vitro tool which we have shared with the scientific community, cannot be progressed to in vivo proof-of-concept experiments because it is too metabolically unstable. We are therefore applying to the MSCA IF to seek medicinal chemistry support to drive a hit-to-lead project to evolve our small molecule hit into a lead candidate with appropriate properties for progression in vivo to carry out key proof-of-concept experiments in animal models of inflammation. This in vivo efficacy data will be pivotal to underpin a future funding application to support drug discovery and development campaigns.


**Keywords:** G protein-coupled receptor (GPCR), biased agonism, free fatty
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Constraining uncertainty of multi decadal climate projections' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

CONSTRAIN will focus research on three climate science knowledge gaps and a policy-facing knowledge gap that can be resolved over the next 4-5 years to significantly improve our understanding of how natural and human factors affect multi-decadal regional climate change. This will cement EU science as the world-leader in understanding climate sensitivity and climate variability, deliver significantly improved capability to make climate projections for the next 20-50 years, and provide up-to-date scientific evidence for international climate policy in two phases: Phase 1 will deliver a timely characterisation of physical science uncertainty and how it affects projections and committed levels of warming to the 2021 IPCC sixth assessment report; Phase 2 will deliver constrained surface temperature projections for the 2023 UNFCCC Global Stocktake. CONSTRAIN will take full advantage of climate model integrations from the sixth Climate Model Intercomparison Project (CMIP6) and will leverage existing H2020 and ERC projects. Novel CMIP6 analyses will be combined with dedicated high resolution simulations and new observations to address identified knowledge gaps on radiative forcing, cloud feedbacks and the relationship between ocean variability and atmospheric change. A fourth identified knowledge gap is the effective translation of new physical science understanding into an improved evidence base for policy decisions. CONSTRAIN will address this by developing climate model emulators that integrate and operationalise learning from across the consortium to provide new capability to assess impacts of climate change under a broad range of emission scenarios. We will focus on the expected spatially resolved decadal changes until mid-century providing robust evidence on climate sensi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Foreign direct investment,internalization and growth with an empirical application to services' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

In this project I will analyze the effects of foreign direct investment (FDI) and licensing on the process of innovation and growth of an economy. Both FDI and licensing involve risks and costs due to the public nature of the technology transferred abroad and incentive and information asymmetries caused by principle-agent problems, which eventually influence the innovation's activities of a firm. The associated internalization issues are well known from the static models on multinationals, but hardly discussed in a dynamic context. It is the objective of this project to explicitly include the internalization issues related to FDI in a dynamic framework to examine the effects on innovation, on the trade pattern, the trade volume, and welfare and to see to what extent trade and industrial policy is useful to support innovation. The theoretical analysis is supplemented by an empirical study, which deals explicitly with FDI in services.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of a high-throughput microplate based device to analyse the patient derived tumour microenvironment' in the context of a Horizon Europe call.

assistant: **Objectives**

Cancer and tumours are exceptionally heterogeneous in tissue and cellular composition, clinical stage, and mutational status. Additionally, the presence of multiple cancers or metastatic tumours in patients leads to complicated drug regimens resulting in high off-target toxicity, unexpected drug resistance and difficulties in understanding the therapeutic effects.Despite a global investment in oncological drug development reaching 5 bn USD, less than 5% of all oncological drugs in the pipeline enter the therapy toolbox. Given the huge burden that cancer poses at all levels in society - leading cause of mortality worldwide, expected to reach 20 M deaths by 2050- technologies that enable pharmaceutical companies to increase the efficiency of drug development may alleviate the threat imposed to the more than 50 M people currently living with cancer.Such technologies include pre-clinical models that represent the tumour microenvironment and reveal the effect of drug candidates in laboratory tumour replicas. To provide clinically relevant information, such models must be patient specific and represent simultaneously the specificity of the target tissue and the cell heterogeneity of the tumour microenvironment. In addition, to be industrially relevant, they must be implementable, reproducible and high throughput. Commercially available solutions do not meet these requirements.3DTUMOUR provides a proprietary technology to produce multiple 3D bioprinted replicas of patient-derived tumour models that faithfully represent the therapeutic target for a drug candidate. 3DTUMOUR aims at increasing the drug development success rate by transferring to industry this pharmaceutical testing platform. The successful outcome of this PoC will provide clinicians with a tool to test the effica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Trans-cis elements regulating key switches in plant development' (TRANSISTOR).

assistant: **Innovation**

TRANSISTOR creates a training network where young scientists carry their projects around a hub of expert laboratories, receiving specialist scientific training at each node on the hub. The projects themselves form part of a coherent larger project, made up of overlapping subunits, building up to form an integrated study of gene regulation, that will be used to develop bioinformatic tools of use to the entire community.The participants' convergent biological interests and complementary technological expertise, make it possible to devise comprehensive individual training programs, which combine to synergistic effect, producing an integrated project on a scale that would be impossible to achieve without funding at the EU level. Biology increasingly depends on genomics; requiring biologists to become proficient in bioinformatics. There is a shortage of researchers with a solid background in wet" biology and bioinformatics. TRANSISTOR addresses this deficiency, helping the European Research Area to achieve critical mass at the interface between developmental genetics, genomics and bioinformatics.We use regulatory genes, controlled by inducible systems, to trigger key steps in flower, fruit and seed development. Micro-array technology will reveal changes in expression of thousands of genes at once. This data will be used by bioinformatics specialists to find co-regulated genes. The promoters of these genes will be analysed for common cis-elements in their promoters. A series of experiments will be conducted to elucidate the promoter architecture of the identified genes and the factors that bind to their promoters.Furthermore, the biological relevance of these interactions will be studied. Data from the whole project will be used for development of new generic bioinformatics t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Automated, Transparent Citizen-Centric Public Policy Making based on Trusted Artificial Intelligence' (AI4PublicPolicy) targeting Horizon 2020.

assistant: **Abstract**

AI4PublicPolicy is a joint effort of policymakers and Cloud/AI experts to unveil AIs potential for automated, transparent and citizen-centric development of public policies. To this end, the project will deliver, validate, demonstrate and promote a novel Open Cloud platform (i.e. AI4PublicPolicy platform) for automated, scalable, transparent and citizen-centric policy management based on unique AI technologies. The AI4PublicPolicy platform will be an Open Virtualized Policy Management Environment (VPME) that will provide fully-fledged policy development/management functionalities based on AI technologies such as Machine Learning (ML), Deep Learning (DL), NLP and chatbots, while leveraging citizens participation and feedback. It will support the entire policy development lifecycle, based on technologies for the extraction, simulation, evaluation and optimization of interoperable and reusable public policies, with emphasis on citizen-centric policies development and optimization through the realization of citizen-oriented feedback loops. AI4PublicPolicy will complement public policy development functionalities with the ever-important process reengineering and organization transformation activities towards ensuring the effective transition from legacy policy development models to emerging AI-based policymaking.The AI4PublicPolicy VPME will be integrated with EOSC with a dual objective. First to facilitate access to the Cloud and HPC resources of EOSC/EGI that are required to enable the projects AI tools, and second to boost the sustainability and wider use of the projects developments. AI4PublicPolicys business plan for sustaining, expanding and commercializing the AI tools and the VPME is based on the development of a community of interested and engaged stakeholders (i.e.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'SAFETY TESTING IN THE LIFE CYCLE OF NANOTECHNOLOGY-ENABLED MEDICAL TECHNOLOGIES FOR HEALTH.'.

assistant: **Innovation**

Society and clinical practice pose a growing demand on novel biomaterials, ICT, micro and nanotechnologies for innovative medical devices and in vitro diagnostics (Medical Technologies-MTs). In addition to the challenge of time, the new technologies are subjected to other pressing factors such as qualification, regulation, cost, biocompatibility and the need to be applicable worldwide. In the most recent years it is obvious that nano-enabled MTs can be applied in nearly every medical area, with a major presence and increased importance in cancer, regenerative medicine, advanced therapies, neurology, cardiology, orthopaedics, and dentistry. On the other hand, any innovation in the Health sector has to be carefully assessed in terms of risk/benefit ratio. Nano-enabled MTs particularly require careful assessment, since they are complex products group and their technological assessments are still under development. This assessment will be a key pillar for the here proposed Open Innovation Test Bed (OITB) To address all the aforementioned challenges, the SAFE-N-MEDTECH consortium aims to bring a strong and competitive cooperation to compete in the market for a coordinated OITB for nano-enabled MTs. SAFE-N-MEDTECH will build an innovative open access platform to offer to companies and reference laboratories, the capabilities, knowhow, networks and services required for the development, testing, assessment, upscaling and market exploitation of nanotechnology-based Medical and Diagnosis Devices. This across the whole Life Cycle. This OITB will offer a multidisciplinary and market oriented innovation  approach to SME´s, Healthcare providers and Industries for the translation to the market of MTs, based on a deep understanding and knowledge of the material-nanoproperties, their a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cell decision capture and control via joint Raman live and omics profiling' (MOVIOLA).

assistant: **Concept**

The developing nervous system generates an extraordinary diversity of cell types through a series of critical fate decisions made by neural progenitors. Despite recent progress in cataloging the heterogeneity of brain cells, we lack an understanding of the factors orchestrating their fine specification, especially in humans. As a result, many decision processes have uncharacterized determinants and are accounted for as stochastic, leaving us without control over them. This knowledge gap stems from the absence of a systematic approach to capture dynamic moments of cell decision-making and discover the factors controlling them.I hypothesize that most fate decisions in the human developing nervous system are not stochastic and, instead, depend on many fine-grained, dynamic mechanisms of cell decision-making. However, only a limited number have been characterized, too few to explain the thousands of cell types in the human brain. To explore this hypothesis, I propose a novel experimental paradigm to elucidate the molecular determinants governing cell decisions. The approach combines live-cell Raman spectrometry imaging, omics profiling, and inducible degrons. I designed it to operate on cell decisions like a film-editing machine, a Moviola: from an outcome, it learns how to “rewind” to a cell’s decision, “halts” the cell and profiles it for decision determinants, and “edits” it to steer it away from the original outcome.By applying this approach, we expect to find factors influencing fate decisions in human neural specification and reveal a more deterministic control of neural cell fates, illuminating how the vast cellular diversity originates from decision-making events. The insights gained will offer ways to improve in vitro models and cell therapies, with potential impli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Polymer-Inorganic Flexible Nanostructured Films for the Control of Light' (POLIGHT) under Seventh Framework.

assistant: **Objectives**

The POLIGHT project will focus on the integration of a series of inorganic nanostructured materials possessing photonic or combined photonic and plasmonic properties into polymeric films, providing a significant advance with respect to current state of the art in flexible photonics. These highly adaptable films could act either as passive UV-Vis-NIR selective frequency mirrors or filters, or as matrices for light absorbing or optically active species capable of tailoring their optical response. The goal of this project is two-fold. In one aspect, the aim is to fill a currently existing hole in the field of materials for radiation protection, which is the absence of highly flexible and adaptable films in which selected ranges of the electromagnetic spectrum wavelengths can be sharply blocked or allowed to pass depending on the different foreseen applications. In another, the POLIGHT project seeks to go one step beyond in the integration of absorbing and emitting nanomaterials into simple flexible polymeric matrices by including hierarchically structured photonic lattices that provide fine tuning of the optical properties of these hybrid ensembles. This will be achieved by means of enhanced matter-radiation interactions that result from field localization effects at specific resonant modes. The opportunity arises as a result of the recent development of a series of robust inorganic photonic structures that present interconnected porous networks susceptible of hosting polymers and thus inheriting their mechanical properties.