RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Wide-ranging Probabilistic Physics-guided Machine Learning Approach to Break Down the Limits of Current Fatigue Predictive Tools for Metals' (BREAKDOWN) under Horizon Europe.

assistant: **Objectives**

It appears paradoxical how today's frontier & high-impact research seeks for designing new materials to delay structural failures – especially fatigue – while the same effort is not seen concerning the way materials can be efficiently and safely used in real structural applications. BREAKDOWN aims to transform engineering products’ design methods by identifying and including a set of (sub)micro-scale material inhomogeneities characteristics in a novel probabilistic framework. The time has come to exploit modern experimental techniques to probe material properties at a small scale, which are scarcely involved in current fatigue characterisation schemes. To attain this very ambitious goal, the project will rely on a breakdown of different classes of inhomogeneities to advance the fundamental mechanical understanding of their contribution to fatigue, and then reunite them within an advanced Bayesian Physics-Guided Neural Network (B-PGNN) frame. Over the past three years, I assiduously worked to prove the feasibility of BREAKDOWN and demonstrate its superior capabilities. However, I have merely scratched the surface of what is potentially achievable with this approach, both in terms of knowledge advancement and real engineering applications. An extensive multimodal experimental characterisation campaign will be conducted on different material inhomogeneity states to separate and identify their individual influence on fatigue in a systematic and detailed way. Cutting-edge numerical & analytical models will be developed and exploited as the physics knowledge in the B-PGNN scheme to effectively tackle the small datasets issue when dealing with fatigue and to ensure soundness of results. The outstanding capabilities of the framework developed in BREAKDOWN will be confirmed thro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Non-Abelian states at zero magnetic field in next-generation moiré MoTe2 heterostructures', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Last year’s discovery of states hosting the fractional quantum Hall effect at zero magnetic field in a lattice system – zero-field fractional Chern insulators (FCIs) – has caused tremendous excitement within the condensed matter community. These zero-field FCIs were first observed – by a team including the applicant – using both optics and transport in a molybdenum ditelluride (MoTe2) moiré superlattice. These states, analogs of the Jain sequence FQH states, host Abelian anyon excitations. However, for certain twist angles, moiré MoTe2 is also predicted to host states with non-Abelian anyons - the main requirement for achieving scalable topologically protected quantum computation. These non-Abelian states have yet to be observed. Perhaps the largest difficulty in moiré systems is sample quality and twist angle control. Contact resistance, strain, twist angle inhomogeneity, bubbles, and polymer residue can preclude the formation and observation of delicate non-Abelian FCIs. The main goal of TOPOMAX is to investigate, using optical and transport measurements, the existence of non-Abelian states at zero magnetic field in ultra-high quality twisted MoTe2 heterostructures. To achieve this, we will implement cutting-edge fabrication techniques that enable unprecedented twist angle control and homogeneity while allowing for devices compatible with optical and transport measurements. In particular, the bent bilayer nanomanipulator technique will enable systematic investigation of zero-field FCIs as a continuous function of twist angle. Determining whether the moiré MoTe2 system hosts non-Abelian states would lay the groundwork for study of zero-field non-Abelian anyons – and perhaps, one day, topologically protected qubits.


**Keywords:** Topological Phases, moiré, 2D material
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Nod factors induced changes in actin cytoskeleton and location of actin-pip2 binding proteins'.

assistant: **Objectives**

Light and growth regulators have major effects on plant morphology thro signal transduction cascades that influence the functioning and architecture of the cytoskeleton. Rhizobium Nod factors also influence the reorganization of the actin cytoskeleton in tips of susceptible root hairs, and this reorganization is induced by activating the inositol phosphate pathway. Using living root hairs as a model system, the link between signal transduction and cytoskeleton driven morphological changes willF be characterized. Actin and actin-polyphosphoinositide (PIP2) binding proteins will be cloned from an available root hair library using heterologous probes. Chimeric constructs with green fluorescent protein (GFP) under the control of a root epidermis specific promoter will be made and introduced into legume roots. The GFP product expressed in eukaryotes is fluorescent and the changes in the actin cytoskeleton and in the location of actin-PIP2 binding proteins induced by Nod factors will be imaged using Confocal Laser Scanning Microscope. Thus, this project will generate knowledge on the mechanism of cytoskeleton driven morphogenesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Printing Ultrasound Stimulated piezoelectric materials for Tissue Engineering'.

assistant: **Objectives**

On an aging society, our quality of life depends significantly in our capability to regenerate or engineer replacements for diseased and damaged tissues. One of these is the osteochondral interface. Over 30% of the population above the age of 65 is affected by osteochondral defects, being the most common cause of disability in older adults. PRIUS-TE (Printing Ultrasound Stimulated piezoelectric materials for Tissue Engineering) aims to regenerate the osteochondral interface with the use of hierarchical piezoelectric materials capable of stimulating mechanically, electrically and chemically the cells. Cartilage is unable to adequately self-regenerate due to its avascular character, the high content of extra cellular matrix (ECM) and the quiescent character of cells within (chondrocytes). Damage or diseases such as osteoarthritis (OA) lead to degeneration, reaching subchondral bone and generating an osteochondral defect. Clinical treatments rely on microfracture techniques that recruit tissue-specific progenitor (or stem) cells from the bone marrow, and form a de-novo cartilaginous tissue. However, the recruited cells are not able to self-organize and differentiate into phenotypically coherent cells. This results in the formation of unstructured and isotropic tissues with impaired mechanical properties that  fail at long term. Current TE strategies are mainly based on isotropic materials that disregard the intrinsic multi-zonal character of the native tissue. PRIUS-TE takes inspiration from the structure and intrinsic properties of the osteochondral interface. It is based on hierarchical scaffolds that mimic the structure, cell microenvironment and fixed ionic charge responsible of the mechanical properties of the native tissue. These gradient, hierarchical and piezoelect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Gate2Start, a ground-breaking model for the successful exploitation of research-based innovation; Bringing entrepreneurship and market expertise at the start of applied research' (GATE2START), addressing dissemination and exploitation.

assistant: **Impact**

Within the Action Plan 'Innovation in Europe' several initiatives, infrastructures and services have been established to assist Innovation for Enterprises, Business Planning and Access to finance. However, only a small percentage of innovative research' based ideas have been able to become funded and to transform into market products. The proposed project believes that break through innovation is an iterative process and it starts at the initial stage of the market - oriented (applied) research. Thus, business aspects, market trends and funding possibilities must be taken into account from time of birth of research idea, rather than when the prototype is already developed. This is more applicable to the ICT sector where the evolution results as a combination of technical progress, legislative evolution, and the emergence of new markets. To validate and formulate the mechanism that will implement the aforementioned model the following workplan is proposed: a) Creation of a roadmap of the ICT sector in Europe including all major key players: researchers, start-ups and spin-outs, serial entrepreneurs, market experts, investors, etc b) organization of awareness seminars to educate researchers and future entrepreneurs on entrepreneurship and market issues, c) Provision of personal coaching to researchers and entrepreneurs d) Organisation of discussion groups and creation of local networks of key innovation actors e) elaboration of a business platform that will enable the interaction of the local networks and the transition of best practices, f) Broader Dissemination of the Gate2Start model via workshops and the creation of liaisons with other initiatives, especially Gate2Growth and PAXIS. The Gate2Start model will be validated by analyzing identifying the parameters that led
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mediterranean configurations: Intercultural trade, commercial litigation and legal pluralism in historical perspective' (CONFIGMED) targeting Seventh Framework.

assistant: **Abstract**

This project will analyse historical change in the Mediterranean over the long run. It challenges totalising narratives aiming to “europeanise” Mediterranean history as having led somewhat naturally to European domination in the 19th and 20th centuries. Instead of the one-sided view of institutional and territorial integration as a consequence of the mere diffusion of European institutional models and legal codifications linked to a supposed lex mercatoria rediviva or law merchant in force in all countries and at all times, the specific approach of this project consists in combining concrete local, regional and thematic approaches with a focus on trade as the most widely accepted interaction even in times of sharp conflict, and on commercial and maritime litigation as an indicator for the intensity and changing modes of intercultural exchange. In an actor-centred perspective, we will take into account a variety of individual and institutional actors involved in trade. Their interaction was based on a combination of shared customs, local usages and legal traditions. Addressing competing instances and drawing on different legal resources, they contributed to a reconfiguration of the legal and institutional landscape.These issues will be investigated through the comparative analysis of commercial litigation and conciliation concerning trade in Mediterranean port cities, with a focus on disputes involving litigants who were not subjects of the local authorities, or whose legal status was linked to their religious identity. The encounters of Muslim, Jewish, Armenian, Protestant merchants and sailors with different legal customs and judicial practices appear as the social sites of legal and cultural creativity. Through the prism of commercial litigation, we will thus achieve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Magnetic evolution of solar-like stars and brown dwarfs' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

With the proposed project the applicant should be enabled to expand his current field of work studying activity and dynamo mechanisms in solar-type stars, and to establish a new scientific field in the EU measuring magnetic fields in substellar objects (brown dwarfs). Having worked in European institutes the outgoing international fellowship should provide the applicant with international experiences and contacts important for a career as researcher and teacher. Research on activity in solar-type stars is established in EU institutes, research on magnetic fields in brown dwarfs has never been studied yet and would enhance EU scientific excellence. For the next few years only one telescope worldwide is suitable to carry out the observations required for these studies (Keck). At the Astronomy Department of UC Berkeley access to this telescope would be provided to the applicant. Telescope access is simplified for collaborators at Berkeley and both parts of the proposed project could be extensively studied. After Phase I in Berkeley the applicant would return to Hamburg in Phase II. At this time data could also be obtained from a telescope inside the European Research Area (CRIRES at the VLT, ESO, available in 2005). With the experiences and collaborations gained during Phase I the applicant would be enabled to establish the new scientific field inside the EU. This field would connect working areas of a number of European institutes. In solar-type stars differential rotation, i.e. different rotational velocities at the Pole and the Equator, should be searched for using methods successfully implemented and published by the applicant. In the substellar regime magnetic fields of brown dwarfs should be measured. For this part the applicant's methods would provide the key mechan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Digital Forest Twins for AI-based Wildfire Assessment' (WildfireTwins), addressing dissemination and exploitation.

assistant: **Impact**

Wildfires have a devastating impact on the environment, infrastructure, animals, and human lives. The complex physical dynamics paired with their unpredictable development makes wildfires a dangerous natural phenomenon that is difficult to counteract. Recently, digital twins have emerged as a concept that combines geometric modeling, image synthesis, and physical simulation with broad applications in predicting real world processes. This proposal aims to develop digital twins for wildfires – 3D models of ecosystems coupled with physical simulations – and to build AI-based tools for wildfire assessment. A wildfire twin with realistic physical simulations will have ground-breaking implications for firefighting services who will be able to use my framework as part of their decision making, resulting in an improved ability to combat wildfires, keep human lives safe and protect the environment. In contrast to existing wildfire simulations, a novel digital twin will provide real-time simulations of wildfires and complex 3D representations of ecosystems. By relying on state-of-the-art computer graphics technology, a digital twin will support generating photorealistic images and videos of wildfires. Synthetically generated data with high visual fidelity will profoundly accelerate the development and adoption of AI-based solutions for managing wildfires, as it addresses the bottleneck of capturing and curating expensive real-world training datasets. A digital twin that supports fast and accurate simulations of wildfires will have major impact on the analytical investigation conducted by the scientific community interested in understanding wildfires by accelerating the evaluation of hypotheses. Additionally, I plan to use the digital twin as a RobotGym – a virtual training enviro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mucosal Tolerance and Allergic Predisposition: Does it all start in the gut?' (ALLERGUT) targeting Horizon 2020.

assistant: **Abstract**

Currently, more than 30% of all Europeans suffer from one or more allergic disorder but treatment is still mostly symptomatic due to a lack of understanding the underlying causality. Allergies are caused by type 2 immune responses triggered by recognition of harmless antigens. Both genetic and environmental factors have been proposed to favour allergic predisposition and both factors have a huge impact on the symbiotic microbiota and the intestinal immune system. Recently we and others showed that the transcription factor ROR(γt) seems to play a key role in mucosal tolerance in the gut and also regulates intestinal type 2 immune responses. Based on these results I postulate two major events in the gut for the development of an allergy in the lifetime of an individual: First, a failure to establish mucosal tolerance or anergy constitutes a necessity for the outbreak of allergic symptoms and allergic disease. Second, a certain ‘core’ microbiome or pathway of the intestinal microbiota predispose certain individuals for the later development of allergic disorders. Therefore, I will address the following aims:1) Influence of ROR(γt) on mucosal tolerance induction and allergic disorders 2) Elucidate the T cell receptor repertoire of intestinal Th2 and ROR(γt)+ Tregs and assess the role of alternative NFκB pathway for induction of mucosal tolerance3) Identification of ‘core’ microbiome signatures or metabolic pathways that favour allergic predispositionALLERGUT will provide ground-breaking knowledge on molecular mechanisms of the failure of mucosal tolerance in the gut and will prove if the resident ROR(γt)+ T(reg) cells can function as a mechanistic starting point for molecular intervention strategies on the background of the hygiene hypothesis. The vision of ALLERGUT is to d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Extracellular Vesicle-Internalizing Receptors (EVIRs) for Cancer ImmunoGeneTherapy' (EVIRs), addressing dissemination and exploitation.

assistant: **Impact**

We are witnessing transformative results in the clinical application of both cancer immunotherapies and gene transfertechnologies. Tumor vaccines are a specific modality of cancer immunotherapy. Similar to vaccination against pathogens, tumor vaccines are designed to elicit a specific immune response against cancer. They are based on the administration of inactivated cancer cells or tumor antigens, or the inoculation of antigen-presenting cells (APCs) previously exposed to tumor antigens. In spite of significant development and testing, tumor vaccines have largely delivered unsatisfactory clinical results. Indeed, while some patients show dramatic and durable cancer regressions, many do not respond, highlighting both the potential and the shortcomings of current vaccination strategies. Hence, identifying and abating the barriers to effective cancer vaccines is key to broadening their therapeutic reach. The goal of EVOLVE (EVirs to Optimize and Leverage Vaccines for cancer Eradication) is to propel the development of effective APC-based tumor vaccines using an innovative strategy that overcomes several key hurdles associated with available treatments. EVOLVE puts forward a novel APC engineering platform whereby chimeric receptors are used to both enable the specific and efficient uptake of cancer-derived extracellular vesicles (EVs) into APCs, and to promote the cross-presentation of EV-associated tumor antigens for stimulating anti-tumor immunity. EVOLVE also envisions a combination of ancillary ‘outside of the box’ interventions, primarily based on further APC engineering combined with innovative pre-conditioning of the tumor microenvironment, to facilitate the deployment of effective APC-driven, T-cellmediated anti-tumor immunity. Further to preclinical trials in mous