RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'How does dopamine link QMP with reproductive repression to mediate colony harmony and productivity in the honeybee?' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Insects pollinate 80% of crop plants in Europe and pollination services contribute €22 billion to the European economy annually. The honeybee (Apis mellifera) is the most extensively managed pollinator species, yet populations are declining. Understanding the biology of the honeybee and and factors contributing to its decline is critical for food security and maintenance of biodiversity.  The honeybee has evolved a remarkable life history strategy where only one female is responsible for the majority of reproduction. The other females, the workers, forgo reproducing to care for the queen and her offspring. The presence of a reproductive queen is communicated via pheromones, arguably the most important of which is Queen Mandibular Pheromone (QMP).  This pheromone inhibits ovary activity in worker bees and in its absence worker bees can activate their ovaries and lay unfertilised eggs that will become males.  QMP is detected by the antennae and brain, but it is not currently known how the signal, initiated by QMP, is passed to the ovary. In this fellowship the applicant will address this fundamental gap in our knowledge by testing her hypothesis that dopamine acts to link the brain and ovary with exposure to QMP in the honeybee. The applicant will determine the role of dopamine signalling in maximising colony productivity and harmony and whether this is altered by sub-lethal doses of neonicotinoid pesticides. The experimental approach proposed in this fellowship is highly innovative as it combines state-of-the-art techniques both for measuring gene expression (RNA-seq) and for ovary culture and transplantation in honeybees. The applicant will combine these molecular approaches with behavioural ecology and colony monitoring (new skills that she will acquire under this fell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cooperation on digital broadcasting convergence with mobile communications between Europe and China' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The MODIBEC project is a 24 months multi-partner Coordination Action that intends to promote and support RTD cooperation between EU and China on Digital Broadcasting technologies especially the convergence with Mobile Communications. It will bring European and Chinese key players in Digital Broadcasting / Mobile convergence areas closer to concrete business opportunities and make recommendations for future actions.The main objectives are to:- Create closer links between European and Chinese Digital Broadcasting and Mobile Communications experts from the industry, research and public sectors to encourage EU-China cooperation on research / application projects, joint ventures, etc.;- Define a common approach to standardisation issues and political strategies to not only strengthen the European industry position on the China market, but also help the Chinese authorities to use the European experience when defining Chinese standardisation;- Support added-value converged technologies in China and their interoperability with the EU deployed solutions;- Increase the visibility of the European industry and support the industry to respond to emerging business opportunities;- Leverage previous and ongoing EU-China IST projects in the same areas by organising conferences, exchange and dissemination of good practice;- Enhance the European participation in major Chinese events, e.g. the Beijing 2008 Olympic Games and the Shanghai 2010 EXPO;- Strengthen the international cooperation activities, and to focus on more concrete priorities for implementation in China and allow the industry to improve the preparation of successful cooperation projects with the Chinese counterparts.The main activities of MODIBEC will be to organise events e.g. workshop, live demonstrations of applications,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Functional long-term imaging of single bouton-spine pairs during optogenetically controlled synaptic plasticity' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Communication between neurons in the brain occurs mainly via chemical synapses. Activity-dependent changes in synaptic strength represent the cellular basis of learning and memory and depend on both the presynaptic terminal and the postsynaptic specialization. Although postsynaptic strength and presynaptic transmitter release have been extensively studied in isolation, simultaneous investigation of pre- and postsynaptic potentiation at spine synapses is still a technical challenge. The laboratory of Thomas Oertner recently established a method to optically identify and resolve the pre- and postsynaptic components of functional synapses in live tissue. The applicant will exploit and further refine this technique by combining optogenetic methods to manipulate electrical activity in the pre- and postsynaptic neurons with high-resolution imaging of structural plasticity and two-photon calcium imaging. As this all-optical approach is non-invasive it permits the investigation of the coordination of pre- and postsynaptic plasticity (transsynaptic matching) over extended time periods. With this new method the applicant wishes to study the precise temporal and molecular processes which control transsynaptic matching at a structural and functional level. As a second step the applicant intends to unravel possible retrograde signals mediated by diffusible retrograde messengers and transsynaptic cell-adhesion molecules. For this he will selectively manipulate individual components of transsynaptic signalling systems at the pre- or postsynaptic side using pharmacological (e.g. selective inhibitors) and genetic tools (shRNA and knock-out animals).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Characterization of the structure and dynamics of a protein complex indispensable for RNA synthesis in Sendai Virus' to be submitted under Sixth Framework.

assistant: **Abstract**

Sendai Virus (SeV) is a prototype of viruses with a negative strand RNA genome. This family of viruses causes important human and animal diseases. RNA synthesis in these viruses requires the placement of the RNA polymerase on the nucleocapsid that assemble s the RNA. This occurs through an interaction between two protein domains: the partly folded PX domain of phosphoprotein P that is part of the polymerase, and the unstructured N-tail domain of nucleocapsid protein N.For transcribing the template RNA, the polymerase needs to move along the RNA, which requires PX to on and off interact with N-tail domains on subsequent nucleocapsids. This suggests that flexibility is a key issue in the biological function of these domains. This project will study the structure and dynamics of this protein complex by NMR, in order to arrive at a better understanding of the transcription process in this family of viruses. Both PX (partly) and N-tail belong to the class of intrinsically unstructured proteins (IUPs), which encompasses around 25% of all eukaryotic proteins. NMR is one of the sole techniques that are capable of studying this class proteins and this project aims at improving NMR methodology optimised for IUPs.The project is part of an ongoing collaboration between the host lab and virus group of Prof. R. Ruigrok at the EMBL in Grenoble. This allows me to both acquire skills related to molecular biology as well as to enlarge my knowledge of NMR in order to further develop myself as a bio-molecular NMR spectroscopist. Furthermore, the experiences in NMR application and methodology acquired during my PhD will prove very valuable for the realization of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The e-wallet Fraud Detection' (EFD).

assistant: **Innovation**

EFD (e-wallet Fraud Detection) aims to provide people with a tool that will dramatically improve credit card frauds and false identity thefts. To date the cost of credit card frauds and false identity thefts worldwide amount to billions of dollars annually. The objective of this project is to implement the e-wallet Fraud Detection (EFD) system and support Self Safe Ltd (SSafe) in becoming a leading provider of mobile fraud detection tools to the emerging market of mobile e-wallets. EFD system objective is to reduce fraudulent financial transactions, using anti-theft algorithms running on the user mobile device. The system works in an off line mode without the need for the device to be connected to the acquirer database.   EFD system detects an unauthorised attempt to make a transaction and prevents it, if it detects a problem or suspicion. The EFD technology will defend e-wallets in transactions at the Point of Sale directly via NFC and also transactions done on the internet. Based on EFD's patented technology (US 61 815798 Self Authentication: “invention directed to the use of mobile devices in offline transactions, and, more particularly, to a system, method and device for self-authentication of transactions”), e-wallet users will have a ""financial transaction firewall"". EFD’s ultra-light fraud detection algorithms and models, offers on-the-spot intervention and prevention of fraudulent financial transaction using the smartphone. In case of fraud, EFD system may instruct the electronic wallet to block all credit cards until issuing a release process while sending relevant information to customer and credit card issuers. The technology enables to cover all credit cards that are approved for use by the smartphone wallet, achieving higher accuracy and fraud detection r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Temporal object oriented databases within information systems' in the context of a Fourth Framework call.

assistant: **Objectives**

TOOBIS aims to develop a competitive Temporal Object Oriented Database Management System that will support representation and querying of bi-temporal data. TOOBIS also intends to develop an innovative conceptual modelling methodology for temporal applications. TOOBIS will contribute to ease of information access by extending the core functionality of DBMSs.The objectives are to:- extend core functionality offered by the O2 OODBMS, by supporting both valued and transaction time and to be compatible with standards of ODMG and the forthcoming SQL-3 standard definitions.- Comply with evolving ODBMS standards, participate and influence standards definition groups.- Extend the functionality of the O2 OODBMSD, by providing Data Model constructs for creating and manipulating temporal objects.- Support Objective O1 by enhancing the O2 Object Definition Language (ODL).- Support Objective O1 by extending the standard high level Object Query Language (OQL).- Provide a temporal analysis and design methodology, by adapting existing methodologies to temporal aspects.- Validate the approach and TOOBIS project (TOODBMS and Methodology) by developing two demonstrator applications.- Gain a competitive advantage with respect to both core ODBMS functionality, and Industrial size applications in the areas of MIS-EIS, and health applications involving temporal and GIS functionality.- Generalise applications of TOOBIS and investigate marketing potential in other industrial sectors.The consortium has chosen Object Orientation as the foundation technology. This is a leading edge technology, which will increase its share in the database market. This may occur either directly, by an increase in the market share of pure OODBMSs or indirectly, by the incorporation of Object Oriented concepts in RDBM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Azabicycloalkanes: Synthesis and Applications' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Small ring azabicyclic amines are predicted to possess unique molecular properties, but lack of synthetic access has to date prevented their thorough evaluation and deployment in high value functional molecules, including drugs. Much recent attention has focused on small-ring carbocyclic frameworks such as bicyclo[1.1.1]pentanes (BCPs), but analogous azabicyclic compounds are poorly described in the literature, which is surprising given the ubiquity of amines in bioactive organic molecules. A literature screen reveals that azabicyclo[2.2.1]heptanes are equivalent to BCPs in frequency of occurrence, but their [3.1.1] isomers and smaller azabicyclo[2.1.1]hexane relatives are much rarer. Azabicyclo[1.1.1]pentanes are essentially unknown, despite one isomer being an attractive bioisostere of the pyridine ring system. This proposal aims to address this ‘void’ in the bioisostere portfolio by introducing ‘small-ring azabicyloalkanes’ (ABAs) as novel motifs of great potential in drug discovery. As well as representing new bioisosteres for biologically-relevant heterocycles (not limited to pyridines, but also piperidines, pyrrolidines, etc.), ABAs offer new opportunities for drug design in their own right due to the impact of the bicyclic scaffold on amine hybridization. This project will deliver general access to small ring ABAs using a wide variety of novel chemical approaches, explore their functionalization, and demonstrate their application. It will use rational theoretical design to tailor ABA properties and develop structural models. Ultimately, this proposal will access a new domain of chemical space with broad application in organic and medicinal chemistry.


**Keywords:** Small ring amines, bioisosteres, propellanes, drug design
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Eliminating turbulence in oil pipelines' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Proof of Concept TURBO FLOWVirtually all pipeline flows are highly turbulent. What is probably less well known is that the major part of the frictional losses in pipelines is caused by turbulence. Already at moderate speeds turbulence is responsible for a 50% drag increase while at high speeds (i.e. high Reynolds numbers) this figure can easily increase to 99%. Annual global pumping costs for oil pipelines alone amount to tens of billions of Euros. If instead the fluid could be maintained in the well-ordered “laminar” motion, pumping costs would drop dramatically. Up to now no methods existed that could convert fully turbulent flows in pipes back to laminar. In the course of the ERC project TURBOFLOW we discovered such a method and we demonstrated that under ideal laboratory conditions a fully turbulent flow can be completely relaminarized and as a consequence friction losses are reduced by as much as 80%.The aim is now to push this technology from the laboratory to practically realistic situations by testing the method in an oil pipe, closely matching the conditions in real pipeline flows.


**Keywords:** turbulence, turbulence control
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Semi-autonomous monitoring and robotics technology', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The SMART network was founded in 1993. The network brings together leading researchers and advanced doctoral students. The network semi-annual European laboratories working in the areas of computer vision and mobile robotics for surveillance and monitoring. The objective of the SMART workshops provide an opportunity for young researchers to expose and discuss recent results and research in progress in a semi-formal setting. network is to develop technologies in the areas of surveillance and monitoring. The SMART II workplan is composed of activities in the areas of The annual SIRS symposium (a EuroConference event) provides an opportunity Video Surveillance and Monitoring", "Mobility for Surveillance and for young researchers to publish and present research results, and to interact with recognized leaders of their field. Monitoring" and "Applications of Techniques for Surveillance and Monitoring". The tasks in these workpackages are designed to build on and The network has also been involved in the design of graduate curriculum, complement existing research activities through the exchange of researchers course-ware and tutorial material. and collaborative research. The SME partners in the network have provided practical internships for young researchers in an industrial setting. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ancient DNA and climatic change: new perspectives from insular environments' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

One of the most exciting issues in modern biology is the use of genetic sequences to examine how modern patterns of biodiversity were generated. While most studies use DNA sequences from living species to investigate the factors promoting diversification and extinction, continuous improvements in ancient DNA (aDNA) techniques have greatly opened up the study of DNA sequences from fossils. aDNA has proved an important new tool for the analysis of past demography, migration and diversity and has revealed how past geological, environmental and climatic changes have shaped current biodiversity and perhaps will influence the near future. Important advances are currently being developed in the recovery of aDNA using hybridisation enrichment and Next Generation Sequencing technologies that open the way for nuclear Single Nucleotide Polymorphism (SNP) typing, and even genomics.In this project we will these methodologies to recover aDNA from a unique fossil bovid, Myotragus balearicus, that lived in the Balearic Islands from at least 5 My ago to its extinction 5,000 years ago. This species is particularly important because of a detailed fossil record in the two islands where it lived, Mallorca and Menorca. The number of preserved bones is remarkable, with more than 150 fossiliferous deposits known, and a wide chronological range (from 100 to 5 kyr). Furthermore, the feasibility of genetic studies of M. balearicus has been demonstrated through preliminary reports of fragments of mitochondrial DNA.Two major research objectives will be pursued through aDNA analyses of samples of this fossil bovid: 1) characterization of populations both within and between island; and 2) understanding the response of M. balearicus to the marked climate changes suffered during its long insular evolut