RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Printed Logic for Applications of Screen Matrix Activation Systems' (PLASMAS).

assistant: **Concept**

The EU has lost a significant share of the electronics manufacture sector to the Far East, resulting in a negative trade balance of >€100bn/year within this sector. This is (in part) due to the current manufacturing technologies that are based on subtractive processing that are expensive, wasteful and energy intensive, making manufacture in the EU economically and environmentally unfeasible. Printed electronics is set to revolutionise the electronics industry by enabling direct, additive processing that significantly reduces capital and operating costs as well as massively reducing process hazardous chemical waste and energy.Currently the EU dominates the innovation and technological know-how in printed electronics. It is very important that this intellectual capital that Europe developed is translated to direct economic benefits by ensuring that manufacture is retained within the EU. However, there are barriers that are preventing widespread adoption of printed electronics including the availability of cost effective, high performance electronic inks, lack of awareness of end-users and lack of integration of individual printed components into large systems.PLASMAS directly builds on world-leading nano-materials, printing and display device technologies developed and patented by the consortium members. Our consortium is unique in that it covers the entire supply chain and also in terms of its ambition. PLASMAS directly addresses the current commercialisation barriers by demonstrating the capability of technology (based on novel copper and silicon inks with favourable cost to performance ratios) through development of printed circuit boards and printed logic as well as displays with printed copper and silicon-based back panels and established “self-emissive” OLEDs and “r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Sustainable batteries'.

assistant: **Objectives**

By the end of 2004 the Commission is required to provide report on the possibility to maintain, or not, cadmium, in the exemption list of Directive 2000/53 on End-of-Life Vehicles. The SUBAT proposal aims to make comprehensive and complete assessment of commercially available and forthcoming battery technologies in the world, including Ni-Cod, on the basis of:-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High-pressure phase transitions in poly-amorphic systems of semi-conducting elements' (2002-2006).

assistant: **Concept**

The project is aimed to acquisition the experimental information about the transformations occurred in amorphous silicon and germanium within wide pressure and temperature intervals, characterization of the different amorphous phases formed under high pressure. This will be done by in situ high-pressure experiments using Raman, infrared spectroscopy and X-ray diffraction. The incoming phase period is based in the University College of London (UCL) using the range of diamond anvils cells installed there for optical measurements. The structural experiments are planned on the X-ray synchrotron sources in SRS (Daresbury, UK) and ESRF (Grenoble, France). The return phase in the Institute of Solid State Physics (Russian Academy of Sciences), is planned to obtain bulk samples of the quenched high-pressure amorphous Si and Ge samples by means of quenching under pressure" method employing large-volume high pressure cells and for measuring the pressure dependence of the super-conducting transition temperature of Si and Ge samples up to 60GPa.The project is a stage of the general research program planned UCL and is directed to complex investigations of the "polyamorphism" phenomenon in the systems demonstrated the first-order phase transitions within liquid (amorphous) state. The experience, experimental skills and technical approaches obtained during the accomplishment of the project will be used for studding ionic-covalent framework liquids such as SiO2 and GeO2 important from the geological point of view. The project can be accomplished completely in the experimental centres of Europe serving for promotion of the intra-European scientific relations. The engaging of the Russian scientists for realization of the research projects in Europe will also work for these very objectives
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The impact of nutrition on fish under multiple stress situations: the influence of lipids in sensitivity to metals and thermal stress' (FISHSTRESS).

assistant: **Concept**

In Europe, natural and man-engineered aquatic ecosystems undergo multiple anthropogenic pressures that challenge their good functioning and/or productivity. Most of ecotoxicological studies have been focusing on single stressor whereas the combined effects of multiple stressors may not simply be additive, but antagonistic or synergistic. Therefore, the FishStress project addresses the question of multiple stressors in fish with a focus on nutrient/nutritional stress, chemical stress induced by metals and thermal stress since these are the drivers of ecosystem health and aquaculture productivity. The main objectives are to determine the effect of nutritional quality, tissue lipid status and selected lipids on the response of fish cells, tissues and individuals to metal (Cd and MeHg) and thermal stress across different levels of biological organisation and to verify to what extent multiple stress effects occurring at higher levels of organisation can be predicted/explained based on observations of effects occurring at lower levels. During the 2 years of the project, different experiments on fish (zebra fish and rainbow trout) will be conducted. On one hand the influence of different FA profiles of fish on their further sensitivity to metal exposure and/or thermal stress will be studied. On the other hand, the influence of metal exposure or thermal stress during fish maturation on the assimilation of different FA will be investigated. The investigation will be conducted at different levels of biological organisation (from cells to population) and will involve molecular biological measurements (e.g. genomic studies, antioxidant enzymes activities) as well as fitness' indicators (e.g. growth, reproduction). Thanks to this approach, the FishStress project will provide a solid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'PORTABLE MONITORING SOLUTION TO SUPPORT CONTINUOUS, ACCURATE AND RELIABLE EXPOSURE ASSESSMENT OF NANOMATERIALS (NMs) FOR HUMAN HEALTH RISK ANALYSIS' (NMs) under Horizon 2020.

assistant: **Objectives**

NanoWatcher is a low-cost and highly accurate innovative instrument, IPR protected, to detect and quantify nanomaterials in air to be used by non-specialised staff.Exposure to nanomaterials (NMs) (particles below 100 nm) leads to up to 4.2 million premature deaths worldwide because they are more toxic than the same material conventionally sized, able to penetrate the lungs and increase the risk of explosion in industrial settings. Moreover, 6 million workers will potentially be exposed to nanoparticles (NPs) by 2020.Current instruments to detect and quantify NPs have significant limitations in detecting polydisperse airborne NPs at industrial facilities, measure unspecific size fractions for human health (<450 nm), are costly (>€12,000), bench-top (>10kg), non-remote operated and use solvent-based working fluids. In addition, they require highly skilled professionals for data interpretation.Nanowatcher is the very first particle counter designed specifically for NM exposure assessment with selective cut-off diameters of 300 and 450 nm, 1-second resolution, and operated with smart data acquisition software for data interpretation by non-expert users. The main benefits of our solution include: portable (<2kg), remote sensing, real-time exposure analysis, stand-alone continuous operation (120h) for long-term exposure studies, water as its working fluid, low maintenance (>18 months), and low price (€6,000).Our targets are occupational health and safety (OHS) professionals working in: (i) Companies manufacturing NMs or nano-enabled products (7,706 in the EU); (ii) Companies exposed to hazardous fine dust particles (>60,000 in the EU); and (iii) External OHS services (~8,500 in the EU).We estimate that the successful implementation of the NanoWatcher project will allow us to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Revolutionary Advances in Photonics Integration Being Applied for Optical Communication' under Seventh Framework.

assistant: **Concept**

Our goal is to develop technology for fast optical communication using revolutionary concepts that challenge the mainstream approaches for photonics integration and packaging. The primary application is optical communication inside high performance computing systems, such as supercomputers and datacenters, but the technologies will also find use in many other applications.Power-efficient InP VCSEL arrays will be directly modulated to provide up to 50 Gb/s signals at 1.3 µm wavelength where optical fibers have no chromatic dispersion. Fast InP photodiode arrays will receive the signals. Our semiconductor optical amplifiers and electroabsorption modulators will be based on novel dilute nitride materials that enable low-cost fabrication on large GaAs wafers and uncooled operation. Passive components will be realised with 3 µm SOI waveguides that are integrated with polymer waveguides for athermal operation and highly efficient, polarisation independent and ultra-broadband I/O coupling. Innovative concepts will radically shrink the footprint of the SOI and GaAs chips, and avoid chip-level processing steps. The hybrid integration of active chips on SOI and the wafer-level packaging of the optoelectronic modules will be based on novel concepts that significantly improve the alignment accuracy, yield, throughput and passive cooling, and also lead to dramatic reduction in the cost and size of the modules.  To increase the datarate and to enable flexible communication between processors we apply advanced modulation formats, wavelength multiplexing and optical packet switching. We demonstrate up to 80 Gb/s per wavelength without offline signal processing, and up to 8 wavelength channels. The concept is directly scalable to Pb/s systems by combining spatial and wavelength multiple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Exploring the potential applications of live viral vaccine encoded small-hairpin-RNAs in improving both vaccine safety and efficacy through RNA-interference and stimulation of the innate immune system' (Super-Vaccine).

assistant: **Concept**

Live vaccines represent one of the most important and effective interventions against the spread of viral disease. As such, they are instrumental in addressing ongoing societal challenges in areas such as healthcare and global food security. However, their capacity to genetically recombine with wild type (WT) viruses circulating in the field remains a primary safety concern. Modifying live vaccine strains to reduce such occurrences would be highly desirable from a safety perspective. Also efforts to enhance the intrinsic potency of vaccine strains would be very beneficial. This would facilitate the use of much lower doses, while reducing the manufacturing resources required to meet market needs and the cost of vaccination programs.With this in mind, this project will explore a novel strategy to improve both the safety and efficacy of live viral vaccine strains by modifying them to express small-hairpin-RNAs (shRNAs), which can be designed to:i) Exclusively inhibit WT virus replication/propagation via RNA-interference (RNAi), thus reducing the levels of WT available for recombination with vaccine strains during vaccination i.e. improving safetyii) Increase live vaccine strain stimulation of the innate immune system by functioning as potent inducers of Type-1 Interferon (IFN-I) expression during vaccination i.e. enhancing efficacyThis novel strategy will be explored by modifying an existing attenuated Cyprinid herpesvirus-3 vaccine strain to express appropriately designed shRNAs, followed by an assessment of their impact on both WT virus replication and IFN-I expression in-vitro, providing a basis for future progression to in-vivo trials.Ultimately, if feasible, this novel vaccine design strategy may be applied in the control of many economically important viruses. Also e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PRIMES: Protein interaction machines in oncogenic EGF receptor signalling' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

PRIMES focuses on the role of protein interactions to assemble dynamic molecular machines that receive and process information to coordinate cellular responses. PRIMES investigates the following: (i) How do protein interactions contribute to the generation of biological specificity in signalling? (ii) How do pathogenetic perturbations affect protein interaction networks? (iii) How can we exploit protein interactions as therapeutic targets? We focus on the EGFR/ERBB signalling network and its role in colorectal cancer (CRC), the third most frequent cancer. The ERBB network is frequently altered in CRC either through overexpression or mutation of the receptors or downstream components. Network components have become important drug targets. Poor response rates and resistance demonstrate we lack sufficient insight to design efficacious therapies. Using proteomics, structural biology, advanced imaging and mathematical modelling we (i) map static and dynamic protein interactions in the ERBB network (ii) unravel the design principles and emergent network properties conferred by protein interactions; and (iii) validate these findings in genetic mouse models of CRC and human tissues. PRIMES aims to (i) enhance the functional pathogenetic understanding of CRC (ii) identify mechanisms of drug resistance and drug efficacy; and (iii) identify drugs that affect protein interactions to rationally manipulate network functions related to individual genetic mutations. Outcomes include (i) a dynamic, mechanistic flowchart of how protein interactions compute biochemical and biological specificity in signalling networks (ii) a functional protein interaction network of healthy and oncogenic ERBB signalling validated in mouse models of CRC and human tissues (iii) network level insights toward
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Magnetic Resonance Shimming Applications with Near-magnet Equipment' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Magnetic resonance (MR) imaging and spectroscopy critically relies on the homogeneity of the main field. Despite of the best technological efforts magnetic field in MR examinations cannot be made homogeneous due to the presence of the object of investigation – the human or an animal – in the magnet. Heterogeneous and unique distribution of tissues with their characteristic magnetic susceptibilities requires the process of field homogenization, termed shimming, to be performed on a subject-by-subject basis. Shimming subsystems of the clinical MRI devices often show insufficient, leading to sub-optimal image quality and even failing diagnosis. Furthermore, numerous emerging methods, while showing their great potential in research settings, require even better shim fidelity. We therefore identify improved shimming as a current unmet need in MRI. Add-on hardware for more reliable shimming will greatly aid MRI research especially in the field of ultra-high imaging, such as 7T and above. A wider availability of improved shimming capabilities in the clinical machines will accelerate the transition of a multitude of current promising scientific applications of MRI to the clinical practise, allowing for a more precise diagnosis and improved patient outcomes. The current project will aid a wider spread of the emerging shimming techniques, not based on spherical harmonics. As these techniques require a higher number of electrically controlled driving channels, the project addresses the scalability problem of the current shim amplifier technology by bringing the equipment closer to the magnet and eliminating a substantial number of expensive and error-prone components. It is therefore to expect that the novel system topology will make future MRI devices cheaper and more reliable, r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Microwave sensors for monitoring of thermoplastic and polyurethane injection processes in the shoe industry.' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Development and implementation of microwave sensors for polyurethane and thermoplastic rubber injection processes, in outsole, insole and heel manufacturing, the innovative character will be based on the development of specific microwave sensors able to control chemical properties of both raw materials ( during the process ) and final product ( inside the mould ) .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Targeting Leukemia Stem Cells' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Targeting Leukemia Stem CellsThe major goals of STEMTARGET is to identify novel targets on leukemic stem cells (LSCs), generate novel insights into LSC biology, and to initiate the development of LSC-directed therapeutic antibodies. The research will focus on three specific aims: (I) To characterize novel cell surface targets on LSCs, identified by in vivo RNA interference screens. (II) To utilize an in-house developed cytokine screen for identification of cell surface targets selectively important for LSCs. (III) To measure receptor expression in patient samples and demonstrate proof of concept for therapeutic effect with antibody-treatment of leukemic mice.Background: In adults, AML has a poor prognosis, and novel therapies are needed. In order to be maximally effective, an important goal for the development of novel treatments is to target all leukemia cells with the ability to self renew and maintain the disease indefinitely, a population termed LSCs. During Dr Järås postdoctoral training at Harvard Medical School, Boston, he and coworkers developed a potent in vivo shRNA screen and used it to identify therapeutic targets in LSCs, towards both small molecules and blocking antibodies could be directed. In addition, Dr Järås has developed a cytokine screen for identification of cell surface targets selectively important for LSCs.In  STEMTARGET, Dr Järås and coworkers will perform further shRNA screens and cytokine screens for the identification and characterization of candidate therapeutic targets on LSCs. Monoclonal antibodies targeting identified cell surface targets will be generated and proof of concept experiments for therapeutic targeting will be performed by treating mice with established leukemia. Successful completion of this research program will identify no