RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The impact of key determinants on the current and future burden of cancer in Europe' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Up to 40% of people ever get cancer in Europe and at middle age 40% of the deaths are due to cancer. Since up to 40% of cancers may also be preventable primary prevention remains essential. Entry-points for preventive interventions were identified based on known risk factors for cancer, partly overlapping with other chronic diseases. Yet, with the exception of hygienic and occupational measures and discouraging smoking, primary prevention was not very successful, especially in lower SES-groups, and avoidable exposure to risk factors demands more attention. This project aims to underpin national and European policies to prevent cancer by providing estimates of the potential impact of interventions on determinants of cancer incidence on the future burden of cancer in Europe. Specifically, we aim to: - Estimate the prevalence and quantitative impact of major lifestyle (smoking, excessive alcohol use, fruit and vegetable consumption, overweight and physical activity) and socio-economic determinants on cancer incidence, concerning cancers of the oral cavity, larynx, lung, oesophagus, stomach, pancreas, colo-rectum, bladder, kidney, breast, endometrium and prostate, comprising 60% of the incidence. - Assess the potential to reduce exposure to these determinants by reviewing evidence of effectiveness of interventions and policies as well as barriers to implementation. - Estimate the future burden of cancer across Europe based on autonomous trends and various scenarios of implementation of effective interventions.This coordination action will generate intensive interaction with national and international researchers and policy-makers, who will provide input to scenario development and reflect on its outcome so that ambitious policies can be rolled out. A special website will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Molecular mechanisms and signification of leafy (lfy) movement'.

assistant: **Concept**

In Arabidopsis, the meristem identity gene LEAFY (LFY) can exert non-cell autonomous effects during floral development. Genetic chimera have shown that these effects are mediated by the trafficking of LFY protein from cells where its mRNA is expressed to cells where RNA is not detected. In plants, such non-autonomous effects mediated by the intercellular transfer of transcription factors have also been reported for KNOTTED1 (KN1) in maize, and DEFICIENS (DEF) and GLOBOSA (GLO) in snapdragon. However, the mechanism and the significance of these movements remain enigmatic. By using LFY as a paradigm, I propose to develop three lines of experiments to address these questions:1) I will determine by targeted mutagenesis the cis-determinants for transcription factors movement and retention;2) investigate the signification of LFY movement in physiological conditions by expressing a movement-deficient LFY mutant mini-gene in a fly background;3) isolate trans-acting factors of LFY movement by using two novel genetic screens.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Open Innovation Ecosystem for Sustainable Nano-functionalized Flexible Plastic and Paper Surfaces and Membranes' in the context of a Horizon 2020 call.

assistant: **Objectives**

Plastic and paper based flexible materials and films are used in a wide range of daily life products e.g. in packaging, furniture surface finish, consumer electronic devices, architecture or in car windows. Applications represent well established multi-billion Euro markets. Key Enabling Technologies for a majority of these applications are based on nano-enabled functionalization of the surfaces. Today, Industry faces game-changing, critical challenges for societal acceptance and economic competitiveness: (1) Overcome plastic waste pollution and follow the European Strategy for Plastics in a Circular Economy towards the development of sustainable materials; (2) Keep pace with digitisation and get products ready for integration of smart systems and intelligent products.FlexFunction2Sustain will be the first European Initiative to support the Industry in overcoming these challenges through a sustainable Open Innovation Ecosystem. FlexFunction2Sustain will develop dedicated services to boost innovation for nano-functionalised flexible plastic and paper surfaces and membranes and offer those services to users, in particular SMEs, in all 28 EU countries through an independent single entry point (SEP) legal entity with multiple regional front offices. FlexFunction2Sustain connects complementary pilot lines to a set of 9 connected lab-2-fab facilities covering all major nano-surface processing techniques for (flexible) plastic and paper surfaces and membranes. The facilities and novel surface functionality will be demonstrated in six relevant industrial application scenarios. 20 pre-commercial pilot cases will demonstrate the Services of the  FlexFunction2Sustain OITBThe FlexFunction2Sustain OITB is prepared to support the client at any point in the innovation chain from TRL4 t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nutri-CARE: Nutrient restriction during Critical illness: from induction of Autophagy to Repression of aberrant Epigenetic alterations' under Seventh Framework.

assistant: **Concept**

Modern intensive care medicine enables survival from previously lethal conditions. Risk of death is mostly attributable to lack of recovery from organ failure. Although intensive care has been practiced for over 6 decades, the understanding of why certain patients recover and others don’t remains very limited. Furthermore, organs and tissues from patients who do not swiftly recover, do not show overt signs of cell death but instead accumulate damaged organelles and protein aggregates and reprogram towards other cell lineages. Accumulation of cell damage can be compared with what occurs during ageing, but much more pronounced and within a much shorter time.  Even when patients survive, many continue to suffer from severe morbidity, referred to as the legacy of critical illness. This indicates that acute life-threatening illnesses, and/or the intensive care management, induce “carry-over” effects with long-term consequences with important humane and financial implications. We recently showed that nutrient restriction early during critical illness is an intervention that affects these processes. Nutrient restriction unexpectedly accelerated recovery from organ failure and enhanced rehabilitation far beyond the time window of the intervention. These data radically contradict the traditional dogma that early anabolism is required for recovery from critical illnesses. Also, they raise the hypothesis that pathways which are activated by fasting play a key role. This project is designed to understand the underlying molecular and cellular mechanisms of the damage-induced “reprogramming” and the benefit of nutrient restriction, which is essential in order to develop novel preventive and therapeutic interventions. We hypothesize that activated autophagy and repressed deleterious e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Classification of pro-p-groups' (1994-1998).

assistant: **Concept**

Research objectives and content A big part of mathematics today is about classifying mathematical objects. In my Cand. Scient. thesis (Oslo 1996), I treated the classification of p-groups and Demuskin-groups using cohomological methods by deformations of the representations. This theory is based on the work of my supervisor, Prof.O.A.Laudal. He showed that any finitely generated pro-p-group G is characterized by its first and second cohomdogy group follows from this, and as far as I can see, so do the groups of order p5 and p6. Therefore I ask myself the following: Can we, by studying abstract Massey-product-structures, get a general classification of pro-p-groups by analogy with the moduli-theory for modules, singularities or Lie-algebras? This can hopefully be reduced to finding the moduli-space for the formal Massey-product-structure on two Fp-vector space H1 nd H2. Training content (objective, benefit and expected impact) Dr. Dan Segal, U. Oxford, is a leading authority on the theory of pro-p-groups, and he has agred to supervise my research. I therefore expect to learn a lot working at the Mathematical Institute in Oxford; how researchers work and, of course, learn more mathematics. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Robust process analytical methods for industrial practice and their validation' (1994-1998).

assistant: **Innovation**

The problem of the agreement between analytical results and their mutual recognition (for checking product specifications) is a problem which concerns everybody who is involved in a buyer-supplier relationship. This is a problem for industry and for the national and international bodies. The quality of the analytical results is not always optimal and the industry would welcome cost-effective improvements. This can be achieved by the introduction of chemometric techniques in industrial analytical practice.The main objectives of the project are- proposing tools for method validation in an industrial context that have been tried and agreed upon by major European industries and thereby assist European standardization in those matters.- advancing the status of method validation in (multivariate) process analytical chemical methods.The development of the GSMV, the SP and the general tools is proceeding according to plan. Several of the already prepared protocols and tools are now being evaluated, tested and validated by the different partners.A general strategy for method validation (GSMV) consisting of a set of good practice guides, accompanied by software will be developed. This involves the validation of analysis methods based on univariate as well as on multivariate calibration.To be able to develop the GSMV it is necessary to study a sufficiently large number of specific packages (SP) for specific instrumental methods and/or applications. There will be 7 SP about e.g. chromatography, capillary electrophoresis, inductively coupled plasma, near infrared spectroscopy and multi-sensor arrays. There is also a need for the development of new or adapted general tools (mathematical, statistical, informatics) to be included in the GSMV.The GSMV is the responsibility of the whole
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'A new competitive liquid biofuel for heating (COMBIO)'.

assistant: **Innovation**

The aim of the project is to verify a new liquid bio fuel chain for heat production. The pyrolysis process is able to produce high yields of liquid products which can be shipped, stored and utilised more economically than solid fuels in the small to medium size class. However, up to date there have been no long-term experiences with pyrolysis oil (PO) in this size class due to lack of sufficient quantities of suitable quality fuel. In this project, large quantities PO are produced, long-term use is carried out, fuel specifications for PO will be determined, PO quality will be improved, and the whole concept from biomass to PO use will be verified from market perspective. It is envisaged that to be able to enter into heating fuel markets, the new liquid bio fuel chain has :1) To be competitive economically with chips, pellets, and light fuel oil (LFO) in heat production, and2) To fulfil specifications required by users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Organ-on-a-Chip technology for in vitro grafting and vascularisation of 3D tissues' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

PROBLEM – The drug development cycle, from basic research to testing efficacy, toxicity, and safety of new therapeutics, is largely depending on animal models. However animal biology and pathology differ from human biology at crucial points. The sector is aware of the significant complications in their usage, but lacks better alternatives. Highly advanced technology exists for the culture of cell systems, organs, tumors, etc. outside the body (‘in vitro’). However, the existing culture models lack functional blood vessels – a vital structure inside the body (‘in vivo’). There is a great unmet need for better models of human biology, to speed up both basic research on human biology as well as the development of novel, much needed therapeutic solutions. SOLUTION – OrganoPlate Graft involves the development to market readiness of the first high-throughput in vitro culture method for vascularized tissue that is unrivalled by the available in vitro options. An extensive proof of concept (PoC) for this method has been obtained. The new product will be launched within 6-months post-project and, for the first time, allow for the study and manipulation of human tissues with functional human vascularization. COMPANY – Founded in 2013, the Dutch SME MIMETAS was the first party to commercially exploit organ-on-a-chip technology that enables accurately controlled and monitored in vitro cultivation 3D ‘mini-organs’. MIMETAS currently employs > 60 professionals, generates year-on year multi-million revenues, and is projected to be profitable as of 2020. RESULTS – The results of the 2-year OrganoPlate Graft project will empower Users by aiding them to grow tissues with human vascularization in vitro – enabling the replacement of a wealth of animal experiments and the design of complete
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Predicting Apoptosis Engagement Downstream of Caspases in vivo' in the context of a Horizon Europe call.

assistant: **Objectives**

Epithelial cell death is widespread during development and tissue homeostasis. While the core pathway of apoptosis is well known, we lack predictive power to understand when and where a specific cell will die in a tissue. Yet, this should have important consequences for clone selection and tissue homeostasis, as exemplified by the process of cell competition. This context dependent cell elimination is essential for tissue homeostasis and tumour progression, but we know very little about its prevalence during normal development. Recent works have characterised multiple non-apoptotic functions of effector caspases and a high frequency of cells undergoing transient caspase activation without death. Yet, what distinguishes a dying from a surviving cell downstream of effector caspase activation is completely unknown. Using quantitative live imaging of effector caspase sensors and caspase activity tuning by optogenetics in the Drosophila pupal notum (a single layer epithelium), we found that cells engage in apoptosis at very variable levels of effector caspase activity. This suggested that the engagement in apoptosis can be developmentally modulated downstream of the most terminal caspase activation and that a completely new layer of regulation of cell death could have important physiological roles. Here, we propose to combine quantitative live imaging, multivariate model, supervised machine learning and quantitative perturbations through optogenetics to define parameters predictive of the engagement in apoptosis downstream of caspase activation. We will then use spatial omics combined with an optogenetic based screening to identify new factors modulating the sensitivity to caspases. Eventually we will unravel the physiological functions of caspase sensitivity modulation by d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Innovative Value Chains for European Ceramic Oxide Fibres'.

assistant: **Concept**

Oxide fibre reinforced ceramics, so-called oxide ceramic matrix composites (O-CMC) have to be considered as strategic materials from now to the future, e.g. for use in next generation aero-engines, stationary gas turbines, power-to-X processes with concentrated solar power CSP, chemical industry, batch carrier for high temperature processes, etc. Today such high-end O-CMC components and the key raw material, the ceramic fibres as reinforcement component, are mainly exclusively produced in the United States. But as these are key components for the European manufacturing, energy and aerospace industry, there is a need to develop a European oxide fibre and O-CMC component industry, decreasing dependence on non-EU producers.The InVECOF project addresses this need and provides a substantial contribution to sustainable product innovation action through the two following key activities:1.to develop a European oxide ceramic reinforcing fibre equivalent to US fibres and to establish it among end users (ROF fibre) and 2.to develop and validate a next-generation fibre in parallel with improved thermos-mechanical properties (NGO fibre). The ROF fibre will present an equivalent to the dominant 3M Nextel fibres with better availability, without dual-use restrictions from the US and possibly lower price is needed and the NGO fibre will have improved thermo-mechanical properties compared to the benchmark fibres in order to make processes, plants, turbines, etc. more energy efficient through higher application temperatures.The project InVECOF Innovative Value Chains for European Ceramic Oxide Fibres covers the whole process chain beginning from fibre development and production over weaving these fibres to fabrics to O-CMC manufacturing, coupons and demonstrators for every end-user appli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'An Artificial Intelligence Capable of Detecting Counterfeit Products Using a Cell Phone Camera' (Microguard) under Horizon 2020.

assistant: **Objectives**

Counterfeiting is a crime, involving the manufacturing or distribution of goods under someone else's name, and without their permission. According to an International Chamber of Commerce, the total value of counterfeit and pirated goods globally is around €1.77 trillion. Each year EU companies lose €83 billion in sales due to counterfeited products. Although the counterfeiting has been a problem for decades, there is no effective solution that allows consumers to simply verify authenticity of products or for companies to effectively protect supply chains. Moreover, counterfeit goods are generally made from lower quality components that put the health and safety of consumers at risk. In these days of international emergency the news report that China has confiscated over 31 million counterfeit medical face masks that have fled the market due to the Coronavirus (COVID-19) emergency. Global retailers such as Amazon and Etsy have also reported cases. Cypheme introduces two AI-based counterfeit detection systems that allow a consumer to determine if a product is an original branded product using only a standard smartphone camera. Microguard labels use a combination of novel security features, including a micro-structured varnish that can only be read with an artificial intelligence technology developed by Cypheme to authenticate the product. Microguard DeepTrace is an algorithm able to extract deep spectral information from printed pigments, providing a revolutionary measure of authenticity without any modification of the packaging or product. Microguard is unique in the level of security it provides and its resistance to forgery by counterfeiters. Microguard solutions have already gained market traction, trusted to protect more than €140 million worth of products. The Phase