RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of culture conditions for the differentiation of hES cells into hepatocytes' (LIV-ES) under Seventh Framework.

assistant: **Objectives**

The liver is associated with many types of diseases which can only be treated by Orthotopic liver transplants. However, shortage of organ donors represents a major limitation for wide-application of this therapy. Additionally, expansion of fully-functional hepatocytes in vitro remains an important challenge for the drug discovery industry. Human Embryonic Stem cells (hESCs) offer a promising new solution to these problems. hESCs are able to grow indefinitely in vitro while maintaining their capacity to differentiate to all types of cells. Here we propose to develop standardized, animal-free culture conditions to promote the differentiation and expansion of fully-functional hepatocytes from hESCs using four complementary Workpackages (WPs): Development of novel tools: WP1 will develop 3-D growth matrices, lentivirus-based reporter systems, liver-specific endothelial cells and a miRNA platform to facilitate the sequential process of establishing standardized, animal-free conditions to produce ES-derived hepatocytes.   Generation of Anterior Definitive Endoderm multipotent stem cells: WP2 will define culture conditions to drive differentiation of hESCs to ADE cells, the earliest progenitors of liver cells during mammalian development. Proof-of-principle of conditions will be validated using the various hESC lines available from partners. Differentiation and expansion of hepatic progenitors from multipotent ADE cells using defined conditions: WP3 will be devoted to the generation of hepatic progenitors from ADE cells. Function will be validated in vitro and in vivo using human foetal hepatic progenitors and HepaRG human hepatoma cells as positive controls. Generation of mature hepatocytes from ES-derived hepatic progenitors: WP4 will generate functional hepatocyte lines sui
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Indium replacement by single-walled carbon nanotube thin films' to be submitted under Seventh Framework.

assistant: **Abstract**

This project aims to develop high performance materials, i.e. both metallic and semiconducting single-walled carbon nanotube (SWCNT) thin films to completely eliminate the use of the critical metals in electron devices: i) Indium in transparent conducting films (TCF, indium oxide doped by tin, ITO) and ii) Indium and Gallium as semiconductor In–Ga–Zn–O (a-IGZO) in thin film field effect transistors (TFTs). The target values for fully flexible transparent electrodes based on SWCNT thin films are 10 ohms/sq at 90% transparency, i.e. comparable to ITO-on-glass, with the midterm milestone of 40 ohms/sq at 90% transparency. The applicability of the developed SWCNT films will be further demonstrated in the high-performance TFTs on flexible and transparent polymer (Ion >1mA/mm, Ion/Ioff >10^5) and in 48 zone capacitive SWCNT touch sensor. Because of the rich resource of carbon element, recycling is not needed and the film material supports the friendly environment approach. During the growth of SWCNTs common transition metal nanoparticles will be used as catalyst.  Based on the fundamental understandings, the performance and reliability of SWCNT transparent conductors and TFTs will be improved in this project, so that they can be used in highly performing products in the long term, such as AMOLEDs and future flexible electron devices with very large commercial potential in future consumer electronics. The project contributes to reduce the European and Japanese electronics industry dependence on the indium resources as well as the cost of manufacturing. Industrial partners from both Japan and EU will be invited to join the dissemination meetings to learn about the project results. Thus the project contributes to increase the competitiveness of the industry, especially to the SM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dismantling, REdialing, personalizing, and implementing task SHIFTing psychosocial interventions to treat and prevent common mental disorders in low-resource settings' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

RE-SHIFT focuses on preventing and treating common mental disorders in people living in low-resource settings. It aims at (a) dismantling psychosocial interventions delivered by non specialist providers into their components, (b) evaluating each component efficacy and redialing the most effective components into a novel task shifting psychosocial intervention, and (c) implementing findings through a worldwide coverage e-learning platform. RE-SHIFT will also develop a publicly available calculator to estimate the efficacy of each component based on individual participant characteristics. Starting from an analysis of individual participant data from all randomized controlled trials conducted in the field of global mental health available on the matter, RE-SHIFT will pioneer a sophisticated study design to unravel which components work best and for whom, identifying at the same time how participant, provider and delivery characteristics moderate the outcome and how beneficial effects of the psychosocial task shifting interventions are mediated. With this information it will be possible to tailor interventions according to the specific needs of diverse populations, allowing the ""RE-SHIFTing"" of available resources to the best of their use. A mainstay of RE-SHIFT is to activate ambitious implementation and dissemination measures to let a different range of stakeholders, lay people, organizations, general public, patient and family organization advocates to know about the project, its aims, deliverables, and potential impact of its findings on the society. Training activities will last for the entire duration of the project, and results will be presented in top-tier international conferences and submitted to high impact factor international peer-reviewed journals. RE-SHIFT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'MLSYSTEM -  heatable, integrated photovoltaics with insulated glass units' (MLSYSTEM), addressing dissemination and exploitation.

assistant: **Impact**

Main objective of this proposal is to launch a novel multifunctional window (MLSYSTEM), which is a glazed insulating glass unit integrated with semi-transparent photovoltaics (panels of all generations) on the EU market. It was developed by a R&D department of ML System. Current available solutions can not be full-competitive to MLSYSTEM. There are PV panels, PV mounting systems, heatable insulated glass units, radiators. The main innovative feature of our technology is a cost-effective integration of properties of all these products. Thanks to 3rd generation solar cells application, higher aesthetic, transparency and better power reduction parameter in relation to any PV technology used so far on Building-Integrated PV sector could be achieved.We intend to contribute to solving one of the European’s main problem, as well as one of the real estate’s market problems. Buildings are the biggest primary energy consumer and Europe’s CO2 emitter. 30% of energy consumed in buildings is used unnecessarily or inefficiently. 30-50% of energy loss is attributed to air leakage and heat transfer. One of the main sources of these losses are windows. Our innovative solution allows for environmental-friendly electrical energy production and thermal energy transfer into a heated room simultaneously manner and is much cheaper than competing solutions. At least 39,000 of tons reduction of CO2 emissions will be achieved every year. Moreover the European efficiency-related construction market is expected to double to €140 billion by 2020 from €70 billion in 2011 - we are ready to exploit this business opportunity.Feasibility study will enable us to verify the technological feasibility and economic viability of launching MLSYSTEM on different EU markets, which will contribute to solving the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Gold-catalysed dehydrogenative cross-coupling of arenes' under Seventh Framework.

assistant: **Concept**

The usually inert carbon-hydrogen (C-H) bond is present in nearly all synthetic and naturally occurring organic molecules. The modification of organic compounds through the direct functionalisation of C-H bonds is however a highly challenging process due to their poor reactivity and the difficulty of discriminating between the many C-H bonds present in most molecules. Nevertheless, catalytic C-H activation has emerged as an increasingly promising strategy for simple and atom-economical cross-coupling of organic compounds. Compared to current methodologies that require the use of pre-functionalized starting materials, the development of general and efficient catalytic C-H activation systems could significantly reduce the amount of waste generated in synthetic reactions by (1) using readily available starting materials (2) shortening reaction sequences and (3) avoiding the stoichiometric generation of metal salts default to synthesis that rely on the use of pre-functionalised building blocks.This project aims at the development of catalytic systems for the formation of biaryls by the direct coupling of two arenes via double C-H activation. Such arylations require the selective breaking of two distinct C-H bonds followed by the subsequent C-C bond formaton. We will make use of the unique ability of gold complexes to discriminate between C-H bonds in different electronic environments depending on the oxidation state of the gold catalyst.  Thus, we will develop catalytic cross-coupling processes proceeding via (1) gold(I) mediated C-H activation of electron poor arenes, (2) oxidation of the catalyst to gold(III) followed by gold(III) mediated C-H activation of electron rich arenes, and (3) C-C bond formation furnishing biaryl compounds. The described proposal will significan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Understanding fire, weather and land cover interactions from long-term terrestrial observations and satellite data in a north to south transect in Europe and North Africa'.

assistant: **Concept**

Long-term historical fire records extending back to the late 1800s are very rare worldwide. Three such long-term historical fire data have been found for this research proposal; (i) Switzerland, central Europe (1900-2014), (ii) Greece, south Europe (1897-2014), and (iii) Algeria, north Africa (1870-2014) which together with the spatial-explicit reconstruction of recent fire history from Landsat satellite images (1984-2016), give a unique and excellent opportunity to understand fire, weather and land use/land cover (LULC) interactions in a north to south transect.Differences in bio-geographical characteristics provided by the three study areas, located on a large geographical gradient covering two continents give the opportunity to document the role of fires in different biomes, to explore cross-scale issues and assess how fire-weather-LULC relationships vary across different scales, especially under a climate change context.This research proposal consists of three topics that correspond mainly to three different scales. The specific objectives are: (i) the identification of trends, patterns and relationships between forest fires, weather, LULC and socio-economic parameters from long-term observations, (ii) the reconstruction of recent fire history and the assessment of burning patterns and fire selectivity on an annual basis from satellite images, and (iii) the exploration of post-fire vegetation dynamics and recovery patterns for selected large fire events using time series satellite images.Those objectives will contribute to the better understanding of fire, weather and land cover interactions, and will therefore provide knowledge for fire and land cover management practices, especially under a climate change context. Understanding of post-fire vegetation dynamics and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Photo-Piezo-ActUators based on Light SEnsitive COMposite' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

PULSE-COM aims to explore technological breakthroughs developing and integrating a new class of Photo-Piezo-Actuators to open a radical new future technology.  Our vision is based on the use of low cost photo-mobile polymer (PMP) films and a lead-free piezo-composite (PZL) to target their use in innovative new fields never before considered. Starting from phenomenological and modelling aspects of the composite materials, we will fabricate and experimentally characterize Photo-Piezo-Actuators (PMP-PZL) proof of concept devices. The project will address through an ambitious interdisciplinary research to the employment of proper materials and the appropriate optical strategies to increase and tune the absorption of the light and finally to increase the PMP devices efficiency. With the same target electromechanical models and innovative growth processes will guide the optimization of the piezocomposite to improve its performance, and thus its sensitivity when coupled with the PMP. The PMP-PZL device will be integrated into more complex opto-electronic systems through high-risk incremental research to achieve pioneering industrial implementation. Specifically, we target the realization of cutting-edge applications based on photo-activated Meso-scale machines as opto-switches and opto-microvalves, Reconfigurable Optics and Photoenergy Harvesting Systems. Our study can open a new window on the future development of light-driven nanomotors and their potential applications in different areas such as biomedical, environmental and nanoengineering fields.


**Keywords:** Piezo-phototonics,  Piezo-electronics,  Photomobile polymers,  Energy harvesting,  Actuators
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Effects of climate change on adult body size: Towards an integrative approach to understand the underlying mechanisms, the consequences across the lifespan, and improve our predictive ability' (CLIMGROWTH) targeting Horizon 2020.

assistant: **Abstract**

Changes in adult body size have become a flagship response to climate change. In organisms with a finite growth, as mammals and birds (higher vertebrates), it is thought to result foremost from climate-induced changes in growth trajectories (plasticity) rather than from changes in the frequency of alleles coding for body size (microevolution). As a key ecological trait, body size is also an important driver of individual life history: individual growth conditions will ultimately determine maturation, reproduction and ageing. However, to date no studies on higher vertebrates have formally investigated the contribution of developmental plasticity vs. microevolution at explaining changes in adult body size in response to climate change and, more importantly, no studies have tested for lifelong effects of climate-induced change in growth and size on individual life history within and between generations. In CLIMGROWTH, I propose to focus on the Alpine swift, a species of outstanding morphological and metabolic characteristics (non-stop flights of up to 200 days), for which preliminary results show a significant increase in body size. In particular, I will use an unprecedented long-term database (>4,000 individuals, >20 years) to combine complex, state-of-the-art, statistical modelling approaches in order to address these knowledge gaps by: (1) testing for the first time in a higher vertebrate the contribution of developmental plasticity and microevolution at accounting for a change in body size in response to climate change using pedigree-based quantitative genetic models; (2) providing long-awaited results on the lifelong consequences of natal climatic conditions on individual life histories, (3) their transgenerational effects on offspring life histories; and (4) addressi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enhanced cybersecurity for networked medical devices through optimisation of guidelines, standards, risk management and security by design' (CYMEDSEC).

assistant: **Concept**

For the EU health industry to be competitive and to sustainably deliver internationally leading care quality, it is important that EU regulation, guidelines and standards enable effective and interoperable digital health innovation and promote a vibrant entrepreneurial EU sector. Safety and competitiveness are not mutually exclusive. To deliver on them requires a pace and intensity of technological innovation that is matched by intensive regulatory innovation. Smarter, adaptive, dynamic, and evidence-based regulatory approaches are needed, based on real world experience in representative use scenarios. CYMEDSEC has been designed with an optimum consortium of regulatory, cybersecurity, technology, evaluation, and clinical EU experts to address exactly this challenge. It provides close feedback loops between new technological paradigms and recommendation of regulatory approaches, fostering regulatory science fresh thinking.It will deliver novel security-by-design solutions for the oversight of ‘Internet of Medical Things’ (IoMT) devices, including connected in vitro diagnostics. IoMT ‘fleet’ cybersecurity oversight systems will be developed. Use cases explored include remote patient monitoring and critical care scenarios, for which the project will develop novel and highly secure gateway middleware. Our technological and methodological advancement will go hand-in-hand with detailed review of regulations and guidelines, the formal creation of a new IoMT cybersecurity standard, and evidence collection from representative case studies. These objectives are holistically interlinked, with learnings form each work area feeding into development and proposals in other areas. Key to this is the in-project development of a cybersecurity benefit-risk toolbox, which will further deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Scanning Microscopy using Active Resonating nanoTips' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This SMART application proposes a technological breakthrough in the field of Atomic Force Microscopy (AFM). It aims at introducing Micro/Nano Electromechanical Systems (MNEMS) as a new generation of AFM probes having outstanding performances in terms of sensitivity and acquisition rate. More precisely, we aim at using bulk mode microresonators to drive an oscillating nanotip in the GHz range. Many applications are expected in the emerging fields of nanobiosciences. AFM systems have been widely used for 20 years in academic and industrial work. They give access to microscopy images at the nanoscale and derived techniques allow many physical characterizations. Many labs are currently trying to use the oscillating mode of AFM to probe biological nanosystems and their dynamics in a liquid environment. However, AFM performances are limited by the AFM oscillator itself. It is typically made of a tip supported by a cantilever beam whose oscillating properties are drastically degraded once placed in a liquid. This phenomenon is due to the hydrodynamic drag and the added mass of the liquid. Consequently, the resonant frequencies and quality factors are too low in liquids to support the force sensitivity and acquisition rate required to probe biological nanosystems dynamics. The SMART project proposes to change the overall AFM oscillator and to choose an oscillation mode in the GHz range that reduces the liquid velocity gradient around the resonator. This new generation of high sensitivity AFM force sensor will be an unprecedented tool for imaging biological and chemical systems at the nanoscale and the possibility of kinetic spectroscopy in liquids. AFM performances are expected to be increased by 3 orders of magnitude. The SMART investigator has a 10 year background in AFM and