RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cultivation of epi- and endothelial cells on biomimetic polymer surface deriving from molecular imprint of flat fibrillar collagen network' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Epithelia and endothelia are specialized cellular linings along animal tissue interfaces, performing tasks like protection, permeability, secretion, and resorption. Reliable in-vitro models are yet out of reach, because this high cell diferentiation can not be fully reestablished under standard culture conditions. Adequate substrate anchorage is essential in this. In vivo, re-anchorage physiologically occurs during tissue development and repair after a phase of cell proliferation and migration is accomplished, whereby contact with underlying extracellular matrix, in particular fibrillar collagen network, is required. With regard to the need of reliability in industrial applications, an innovative approach for the generation of artificial culture substrate, the surface of which could mimic such cell environmental aspects shall be explored. Fibrillar collagen associated properties which are involved in cell adhesion and morphogensis shall be examined. They may be topological, physicochemical, and biotechemical in nature and may have various size scales. Such structural motifs are to be transferred from in-vitro formed flat fibrallar collagen networks to polymer surfaces by molecular imprinting. This method involved contact polymerization on a biological template to form a negative relief which, in turn is imprinted by another polymer, generating multiple positive molds which supposedly have a biomimetic surface. The ultrastructure of biological and artificial templates as well as transfer characteristics are to be analysed by means of atomic force and scanning electron microscopy. Biological and artificial substrat activity will be assayed in cultures of vascular endothelial and corneal epithelial cells, respectively. The biomimetic substrate shall be optimized and applie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Robust Asics for automotive'.

assistant: **Objectives**

ROBAS partners will further ruggedise" automotive ASICs with regard to handling and use, by improving ASIC specification and actual performance in the areas of ESD protection, sensitivity and emission of Electromagnetic Disturbances (EMC) and in-silicon disturbances by substrate coupling and transmission effects.Reliability levels of less than 10ppm failures without expensive burn-in screening will be sought by "designing-in" and "building-in" reliability with such measures as wafer-level-reliability (WLR) practised in manufacturing and improved fault simulation and built-in test features during design.Operation and performance at increased ambient temperature, form the present 85°C up to 135°C will be targeted and implemented.Two robust ASIC demonstrators will be developed to demonstrate the improvements achieved by the project. These will be a radio-security-key and a general purpose chassis ASIC with uP core for security applications.Increased functionality in automotive safety, performance/economy, and comfort requires an ever increasing electronic content in modern motor vehicles. Additionally bus-wiring systems and increase integration level often push the electronic functionality temperature, humidity and electrical disturbance signals.On the other hand customers demand improved reliability, with component failure rates at the ppm level, simultaneously with the increased complexity.ROBAS addresses the issue of improved reliability in the hostile environment and describes improvements at all levels in the ASIC design and manufacturing chain."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Hydraulic pressure and flow control valves with encanced fluid dynamic and wear performance'.

assistant: **Concept**

With pressure and flow control valves the energy of the hydraulic fluid is dissipated in a very inefficient manner. Sharp bends and non-ideal flow paths typically cause : * considerable vortexing and turbulence * very low discharge coefficients (through orifices) * low accuracy of flow control * extraneous heating of the working fluid (which sometimes requires compensation down-stream) * excessive pressure losses and power wastage * increased wear of the component and objectionable noise These leads to reduced component lifetime, increased failure potential, reduced overall efficiency and higher power input. By definition, hydraulic systems will operate at high pressure and in some instances these will be at high temperatures too. Many hydraulic fluids are also flammable. In this respect. failure of a hydraulic valve is very undesirable. It is the proposal of this project that it will be possible to significantly improve the flow dynatnics and wear resistance of existing hydraulic pressure and flow control valves by performing an in-depth computational fluid dynamics (CFD) and materials analysis. The main RTD goals and intentions are summarised below : Design, configuration and CFD analysis of a range of alternative flow and pressure control valve systems to minimise vortexing and turbulence by improving fluid flow paths. Identification and evaluation of alternative valve materials (such as ceramics) in order to decrease erosive wear processes and hence increase operational life-time. To undertake a detailed experimental and industrial testing programme to fully evaluate and optimise the performance of the configured designs. The successful completion of the above will significantly increase the overall efficiency of hydraulic systems as well as reducing power wastage a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Elimination of NOx, SOx and Particulates in Rail Transportation'.

assistant: **Concept**

Locomotive engines are significant contributors to air pollution in many cities and ports. Although locomotive engines being produced today must meet relatively modest emission requirements set in 1997, they continue to emit large amounts of nitrogen oxides and particulate matter (PM).The 2008 Clean Air Non-road Diesel Rule stipulates new requirements for non-road diesel fuel that will decrease the allowable levels of sulphur in fuel used in locomotives by 99 percent. These fuel improvements will create immediate and significant environmental and public health benefits by reducing PM from existing engines. The rule also establishes long-term, Tier 4, standards for newly-built engines based on the application of high-efficiency catalytic aftertreatment technology, beginning in 2015.Although established Selective Catalytic Reduction (SCR) processes appear effective, there remain several problems such as high reaction temperatures, which sometimes require reheating of the flue gas, a large reactor volume, and the need for reductant ammonia. In addition, the process is not applicable to NO in low concentrations and at ambient temperature. As NO2 is easily removed by water, catalytic oxidation of NO to NO2 at a low temperature is a promising way of removing NO in flue gas without using ammonia.In the ENSPIRIT project, the core research work will focus on the production of a pre-production prototype catalytic device for NO oxidation over Activated Carbon at ambient temperature. The catalytic device will be integrated into a system of combined devices for the removal of heat, moisture, Sulphur oxides, ultrafine particulate matter and Nitrogen oxides. The integrated ENSPIRIT system will provide a complete cost-effective, energy-efficient way of meeting the EPA Tier 4 non-road e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The synthesis of the galbulimima alkaloids himgravine and himbacine - potential therapeutic agents for alzheimer's disease', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

In the last decades isolation and screening of natural products has become a very important factor in finding new therapeutic agents. During this project a synthesis for the Galbulimima Alkaloids Himgravine 7 and Himbacine 8 should be developed. These Alkaloids should stimulate the release of acethylcholin and due to the cholinergic hypothesis should alleviate the symptoms for Alzheimer's disease. A retrosynthetic approach, as illustrated in scheme 1, shows that suitable building blocks can be prepared starting with substrates from the chiral pool like amino acids, lactic acid 1 as well as heterocycles 6 by using various standard organic reactions (C-C coupling reactions, protection and deprotection of functional groups and stereoselective synthesis). Modern analytical methods like HPLC, GC, NMR-, IR- and Masspectrometrie will be used to identify the intermediates and products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'CogBooster: Rebooting Psychological Research through Cognitive Neuroscience' (CogBooster) targeting Horizon Europe.

assistant: **Abstract**

CogBooster aims at contributing to closing the research gap in Psychology between Widening and non-Widening countries by implementing a strong line of research in the area of Cognitive Neuroscience at the Psychology Department of the University of Coimbra, Portugal. It will do so under the leadership of one of the most respected and highly cited researchers in the fields of Psychology and Cognitive Neuroscience – Alfonso Caramazza. Importantly for CogBooster, Alfonso Caramazza successfully created and led research centers and departments to excellence in the field of Psychology and Cognitive Neuroscience, both in the United States of America, as well as in Europe.CogBooster will promote an institutional reform to align the Coordinator Institution with the cutting-edge psychological research and education currently provided in the Psychology Departments within non-widening European countries, and in the top Psychology Departments in the world. A close inspection of the major differences between Psychology Departments in Widening and non-Widening countries suggests that the presence of strong and dominant lines of research in Cognitive Neuroscience marks the divide between these two groups of countries in what concerns Psychology. To contribute to closing this research gap and increasing research quality and competitiveness at the University of Coimbra, the institutional reform under CogBooster will focus on: 1) attracting talents in the area of Cognitive Neuroscience to Portugal; 2) improving research and education, by providing top notch training in an area that is central for resolving complex societal challenges; and 3) bringing these scientific outputs to society. Overall, the scope of this action extends to the whole system: academia, target users (e.g., students),
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structure, stability, folding and function of the tumour suppressor p16' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content Regulation of the cell cycle is critical for the development of multicellular organisms and loss of control can lead to cancer. The molecular processes unravelled so far have been shown to be essentially the same in all eukaryotic cells. For a deeper understanding of the cell cycle machinery the structure, function, stability and folding of its component proteins need to be characterised. p16INK4 is a specific cyclin D-dependant kinase inhibitor and a multiple tumor suppressor involved in cancers of the skin, pancreas, oesophagus and bladder. Inactivation of p 16 is frequent in both primary tumors and tumour-derived cell lines. Preliminary studies have shown that the common mechanism of inactivation of pl6 may well be defective folding. Experiments are proposed here to investigate the folding pathway and the mechanism of inactivation using protein engineering combined with equilibrium stability measurements and fast kinetic measurements. Also a detailed structural analysis of peptide fragments of pl6 (in collaboration with Prof. D. Lane, University of Dundee) and of the molecular recognition of p 16 and cyclin-CDKs will be performed using Nuclear Magnetic Resonance (NMR). Training content (objective, benefit and expected impact) The training objective of this research project is to obtain a PhD degree from the university of Cambridge and acquire skills in a wide range of biophysical techniques as well as in protein engineering and protein expression and purification. The laboratory of Professor A.R. Fersht, F.R.S., is a stimulating environment for this purpose. It provides first class facilities and technical expertise for training in the multi-disciplinary aspects of the project. I expect to benefit also from the scientific environment o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Molecular Applied to Invertebrate Evolution. Systematics on Tardigrada'.

assistant: **Objectives**

Tardigrada is an invertebrate phylum that comprises more than 959 species of micrometozoans, which size is up to 1.2 mm. Tardigrade are interesting by both, their capacity to survive under unfavourable conditions in a latency state called cryptobiosis, and their controversial phylogenetic position within Invertebrata. Tardigrade research has been restricted to the more basic topics (taxonomy and basic ecological patterns), being biased and incomplete. Remainder information continues to be neglected. As a result of this lack of information, the main objective of this proposal is to progress in knowledge on Tardigrada evolution, using all the information we will be able to generate. One of our main objectives will be to include more taxa (families Hypsibiidae, Calohypsibiidae and Macrobiotidae and, if possible, Microhypsibiidae, Necopinatidae, and Apodibius) and different genetic markers (5.8S rRNA, Histone H3, heavy chain of Myosin, elongation factors-1α and 2, RNA polymerase II, and EST sequences) in phylogenetic analyses. On the other hand, we would like to examine specimens from all genera from class Eutardigrada in Tardigrada collection from University of Copenhagen, to update morphological matrix from Guil´s Thesis with direct observations. Once we have a stable phylogeny, we will study the evolution of different characteristics in tardigrades (reproductive modes, their distribution through different habitats, claws and buccopharyngeal apparatus morphology, substances from cryptobiosis and cryptobiosis as a process itself), using the comparative method in phylogenetic analyses. An increase of knowledge within tardigrades will probably solve, or at least will help, to understand Ecdysozoan evolution, since this is, probably, a key taxa in evolutionary understanding.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A novel direct role of non coding RNA in DNA damage response activation' under Seventh Framework.

assistant: **Concept**

DNA, if damaged, cannot be replaced. If not replaceable, it must be repaired. The so-called “DNA damage response” (DDR) is a coordinate set of evolutionary conserved events that arrest the cell-cycle (DNA damage checkpoint function) in proliferating cells and attempts DNA repair. Until DNA damage has not been repaired in full, cell proliferation is not resumed in normal cells.DNA damage is a physiological event. Ageing and cancer are both associated with DNA damage accumulation. In the past, we contribute to better understand the mechanisms and the consequences of DNA damage generation and DDR activation in both settings.We have recently identified a completely hitherto undiscovered level of control of DDR activation, so far considered a proteinaceous only signaling cascade. We have discovered that short RNA species are detectable at DNA damage sites and are necessary for DDR activation at DNA lesions. These RNA species are generated by an evolutionary-conserved RNA processing machinery. However, they serve purposes never reported before.We believe that our findings change radically our understanding of DDR modulation in mammals and disclose a fertile unspoilt ground for exciting investigations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Design of froths and foams with entailed durability' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This proposal aims at creating a methodology for the design of froths and foams of pre-conditioned durability. Such a methodology is greatly needed nowadays, because of the numerous applications of the froths and foams. The life-time of single foam films and the durability of froths/foams will be investigated under matching conditions. The effects of the bubble speed and bubble sizes on the durability of froths/foams will be studied for a wide range of Gibbs elasticity values. Furthermore, the durability of foam films and froths/foams containing nano– and micro-hydrophilic and/or hydrophobic particles will be studied as well. The effect of the material of the foam column on the lifetime of froths and foams will be investigated additionally. In addition, a link will be established between the behaviour under identical conditions of the single foam films and the respective foam column. There is still a drastic lack of linkage in the literature between the results for foam films and foams, due to their isolated studying. Ultimately, the main factors affecting the durability of froths and foams will be brought together in a methodology for the design of foams of a wide scope of durability – from seconds to hours.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Solar To Hydrogen Hybrid Cycles' (SOL2HY2), addressing dissemination and exploitation.

assistant: **Impact**

The FCH JU strategy has identified hydrogen production by water decomposition pathways powered by renewables such as solar energy to be a major component for sustainable and carbon-free hydrogen supply. Solar-powered thermo-chemical cycles are capable to directly transfer concentrated sunlight into chemical energy by a series of chemical and electrochemical reactions, and of these cycles, hybrid-sulphur (HyS) cycle was identified as the most promising one.The challenges in HyS remain mostly in dealing with materials (electrolyser, concentrator, acid decomposer/cracker and plant components) and with the whole process flowsheet optimization, tailored to specific solar input and plant site location. With recent technology level at large-scale hydrogen production concepts hydrogen costs are unlikely to go below 3.0-3.5 €/kg. For smaller scale plant, the costs of hydrogen might be substantially higher.The present proposal focuses on applied, bottle-necks solving, materials research and development and demonstration of the relevant-scale key components of the solar-powered, CO2-free hybrid water splitting cycles, complemented by their advanced modeling and process simulation including conditions and site-specific technical-economical assessment optimization, quantification and benchmarking. For the short-term integration of solar-power sources with new Outotec Open Cycle will be performed. Simplified structure, extra revenues from acid sales and highly efficient co-use of the existing plants may drop hydrogen costs by about 50-75% vs. traditional process designs.Besides providing key materials and process solutions, for the first time the whole production chain and flowsheet will be connected with multi-objective design and optimization algorithms ultimately leading to hydrog