RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'GYROSCOPE: A multidisciplinary approach to host-shifting and invasive potential by gyrodactylid parasites' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Problem: In a global economy, the transfer of parasites to novel hosts can pose a major threat to both farmed and wild animal stocks. The effects of parasite invasion can have significant impacts on rural economies and biodiversity, but are difficult to evaluate in the short-term, since adaptation to new hosts occurs over an evolutionary time-scale.Aims:- To study neutral genetic changes and adaptive evolution of morphology and virulence of gyrodactylid parasites associated with historical translocations of the guppy (Poecilia reticulata).- To design a web-based database of gyrodactylids featuring genetic, ecological, morphological and biogeographic data. Background: The guppy has been translocated to ca. 40 countries worldwide over the last 75 years, resulting in the widespread introduction of non-native gyrodactylids.This group of fish-parasites consists of ca. 20,000 species, the majority of which are still unknown to science. Gyrodactylids are renowned for their colonization abilities and pathogenicity, and one species alone, Gyrodactylus salaris has cost the Norwegian Salmon Industry >500 million € in 25 years. Gyrodactylids demonstrate biological plasticity including host-shifts, an evolutionary characteristic important for parasite invasion. Plan of work: We will utilize a multi-disciplinary approach (GYROSCOPE), integrating morphometrics, molecular systematics and experimental parasitology to identify and describe novel species, to study their invasion potential, and to evaluate DNA barcoding.Analysis is performed at three evolutionary time-scales:- Macroevolutionary - natural range (5MYA),- Mesoevolutionary - human introductions (75 years), and- Microevolutionary - laboratory experiments (less than 10 years). Implications to EC: The proposal work will directly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Extension in collisional orogenic belts the late cretaceous of Alps and Carpathians' in the context of a Fourth Framework call.

assistant: **Objectives**

The proposed project plans to carry out a collaborative study on lithospheric-scale structures on extension within a contractional orogenic setting as represented by the Late Cretaceous of internal Eastern Alps and Carpathians. The main goals are the investigations of (1) field structural relationships of exhumation of metamorphic domes and sedimentary basins adjacent to it over the entire Alpine- Carpathians area; (2) to model numerically subsidence within the Late Cretaceous sedimentary basins; (3) to proof possible diachron- eity of Late Cretaceous tectonic processes within that area; (4) to carry out analogue modelling; and (5) to carry out lithospheric-scale numerical modelling of Late Cretaceous tectonic processes in Alps and Carpathians.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Complexity in simple dynamical systems' (1994-1998).

assistant: **Innovation**

A proper understanding of complex behaviour in dynamical systems is still lacking. However, work on nonlinear systems have demonstrated that apparently complex processes can have simple origins and provide a variety of paradigms. - The objective of this project is to develop and investigate a model of a driven granular system. The model will be based on an experiment in which a transition from a critical behaviour into a non-critical behaviour is observed as a function of a relevant control parameter. In driven granular system, avalanches constantly modify the slope and thus create a dynamical medium disorder that changes all the time. - The aim is to explore the relevance of introducing dynamical disorder into dynamical models of e.g. 1/f noise.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mechanisms of Transcription Proofreading' (MTP) targeting Seventh Framework.

assistant: **Abstract**

Transcription, the copying of DNA into RNA, is the first step in the realisation of genetic information. RNA is either directly used by the cell or decoded into proteins during translation. The accuracy of transcription is thus essential for proper functioning of the cell. In all living organisms transcription is performed by multisubunit RNA polymerases, enzymes that are highly conserved in evolution from bacteria to humans. Surprisingly, the mechanisms that ensure accuracy of transcription remain largely unknown. Recently I discovered a novel mechanism of transcriptional proofreading used by bacterial RNA polymerase. I showed that the RNA transcript itself assists RNA polymerase in identifying and correcting mistakes. This discovery led to the hypothesis that this transcript-assisted proofreading is the universal mechanism of transcriptional error correction in all three domains of life. In this proposal we will investigate this hypothesis and search for other mechanisms of transcriptional proofreading used by bacterial, archaeal, and three eukaryotic RNA polymerases. For the first time experimental systems will be built for the simultaneous investigation of transcription elongation complexes formed by bacterial, archaeal and eukaryotic RNA polymerases I, II and III, which will be used to elucidate the mechanisms of error correction used by these RNA polymerases. Using molecular modelling, directed mutagenesis and in vivo screenings we will investigate the impact of these proofreading mechanisms on the total fidelity of transcription in vitro and in vivo. Experimental systems built in this research may be of use for screening of potential antibacterial and antifungal drugs taking advantage of the simultaneous investigation of RNA polymerases from all domains of Life.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dissecting the functional pathways of B cell receptor immunoglobulin in antigen driven mature B cell lymphomas' to be submitted under Horizon 2020.

assistant: **Abstract**

The B cell receptor immunoglobulin (BcR IG) is important for the ontogeny and evolution of malignancies of mature B cells (B cell non-Hodgkin lymphomas, B-NHLs), mediating critical interactions with the microenvironment, including recognition of and selection/activation by antigens. Of note, inhibition of BcR IG-mediated signaling has emerged as a highly efficacious treatment mode for these tumors, highlighting their dependence on extrinsic triggering. Nevertheless, open issues abound regarding the precise role of the BcR IG in lymphomagenesis, particularly regarding the range of interactions with antigens and their functional impact on clonal behaviour and patient outcome. IGpath is an original multidisciplinary project combining innovative methodologies with the aim of dissecting BcR IG-related mechanisms and processes implicated in the pathogenesis of mature B-NHLs. The focus will be on splenic marginal zone lymphoma (SMZL) and chronic lymphocytic leukemia (CLL), and monoclonal B lymphocytosis, a pre-malignant condition that is considered as a potential precursor state to CLL. IGpath is grounded on the combination of the applicant’s scientific background and skills with the expertise and infrastructure of the Host, thus guaranteeing  the bidirectional transfer of knowledge. Therefore, it is anticipated to lead to novel insight into the fundamental mechanisms of lymphomagenesis, holding the potential to identify novel actionable targets and novel prognostic/predictive biomarkers. Moreover, thanks to a carefully designed research strategy and implementation plan, the applicant will acquire valuable skills in novel techniques, project management, and networking, thus setting the basis for an independent career in science.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Spent fuel stability under repository conditions' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

This project aims to develop and validate a reliable and robust model to predict the radionuclides (RN) release rate as a function of time for the spent nuclear fuel (RN source term), which can there after be used in the performance assessment exercises for repository systems.The development of such source terms models requires:(i) a scientific consensus of what are the major mechanisms and(ii) the acquisition of key parameters by dedicated experiments on real and simulated spent fuel.This project will focus on the major scientific issues for the RN source terms:(i) the evolution with time of the Instant Release Fraction which is instantaneously released when water arrives,(ii) the mechanisms governing the grains alteration and the subsequent RN release the solubility controlled or radiolytic dissolution,(iii) the development of a global, robust and consensual predictive model for the RN release rate from spent nuclear fuel.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Fluidity in the Medieval Aristotle. Readers and Readings of the Greek-Latin Translations', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Aristotles impact on philosophy, science, and theology has been overwhelming, especially in the late medieval and early modern periods: hundreds of Aristotelian manuscripts survive to attest how strongly his works belong to the written culture of the pre-modern intellectual world. The understanding of Aristotles thought was decisively shaped by Latin translations from the 12th and 13th centuries. Translators efforts to preserve the exact phrasing of the texts and readers struggles to determine the disturbingly novel meaning lie hidden in modifications and notes in the manuscripts. These have however not received the attention they deserve, leading to a significant gap in our knowledge of the medieval reception of Aristotle. FitMA aims to fill this gap through a comprehensive investigation into the new ways to read the Latin Aristotle, with a ground-breaking focus on the textual variance in the handwritten books that preserve the translations. To realize that goal, FitMA will produce state-of-the-art critical editions of Greek-Latin translations of three of Aristotles most influential treatises on natural philosophy: De anima, De generatione et corruptione, and De caelo. Critical editions are the established scholarly means to document the variant readings in all manuscript witnesses of an ancient or medieval text. The study of that variance across versions or textual fluidity provides first-hand evidence how readers were exposed to the recently available translations, which are fundamentally different from their Greek originals. Because every manuscript copy of the Latin Aristotle generates a different state for its medieval reception, which cannot be adequately studied from the Greek text or a modern translation, FitMA will advance the state of the art by uncovering th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'optiSLATER: Automated Classification System for the categorization of slate slabs.' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Slate manufacturing heavily relies on subjective and costly manual work for the quality control and categorization of its products during which the price of the final product is defined. Due to the subjectivity of this manual process and the labor shortage dur to hard and harmful working conditions (carcinogenic components), this industry is urgently requiring accurate, unbiased and automated classification systems, able to reduce production costs, increase productivity, competitiveness and traceability but also improving the working conditions of the employees. In ITCN (Spain, 2016) we are working for bringing technology to the traditional slate sector. We have developed optiSLATER: the first automated classification system for slate slabs. It provides for the first time an unbiased and consistent categorization of slate slabs x6 times faster than the manual process while guaranteeing the traceability of the final products. Based on computer vision & artificial intelligence algorithms, optiSLATER retrieves and analyze in a few seconds all the relevant parameters to classify the slabs solving the subjectivity of this crucial process w. Besides, it allows the full traceability of the products as it generates a report with all the classification parameters per slate batch as well as a code bar. optiSLATER can increase x5 the productivity of the slate manufacturing companies (46,000 slabs vs. 9,200 manual classification in a shift) avoiding the contact of the employees to the harmful slate dust. optiSLATER can be assembled with our own packaging and palletizingunits to offer a complete automated solution to for the final slate processing steps.Based on direct sales, we will offer optiSLATER to the European slate manufacturing companies (B2B) expecting to gain more than 100
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'From youthful vigor to maternal wisdom: signaling pathways in oocyte aging'.

assistant: **Innovation**

In developed countries, modern lifestyle often leads women to postpone their decision on when to have children. By 2022, the average age at which women in Europe give birth to their first child had crossed 30. Unfortunately, delayed motherhood is associated with a decline in women's reproductive potential, which can manifest as difficulties with conception, miscarriages, or an increased risk of delivering a child with chromosomal abnormalities. This decline is primarily attributed to the fact that oocytes, the reproductive cells, gradually lose their quality and fertilization potential with age.The primary object of the FRASP (Female Reproductive Ageing - Signalling Pathways) Proposal is to gain insights into why oocytes lose their reproductive capacity as women age. Recently, several signalling pathways have been identified to be involved in the aging of oocytes and the cumulus cells that directly surround and interact with them. However, our current understanding remains limited, and this knowledge may not have an immediate impact in the near future.This Proposal aims to comprehensively analyse the signalling pathways responsible for aging in oocytes and cumulus cells derived from mice. To achieve this, we will employ a range of high-throughput techniques comprising for multiOMICS approach. Signalling pathways will be investigated at the RNA, protein, and metabolite levels. Additionally, we will explore how these pathways influence the outcome of fertilisation. We believe that our approach will provide a profound understanding of the intricate molecular mechanisms that occur during oocyte aging, ultimately offering potential molecular targets for therapeutic interventions.


**Keywords:** reproductive aging, advanced maternal age, oocyte aging, cumulus-oocyte complex,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Xene Fabrication for a Two-Dimensional Nanotechnology Platform' in the context of a Horizon 2020 call.

assistant: **Objectives**

Xenes denote two-dimensional (2D) monoelemental (X) crystals beyond graphene with a honeycomb lattice. Unlike graphene, Xenes do not exist in Nature, but they become stable via epitaxy on substrates. So far experimental evidences of Xene epitaxy have been reported for X=Si, Ge, Sn, B, P, and Sb (named silicene, germanene, stanene, borophene, phosphorene, and antimonene, respectively). Xene single layers also serve as a background for the synthesis of new Xene-related materials (XRMs) such as Xene heterostructures and functionalized Xenes. Xenes can appear as metals, semimetals, semiconductors, and topological insulators thus allowing for a broad range of applications in nanotechnology. However only silicene has been integrated into transistors operating at room temperature albeit fast degradation. Nonetheless, a viable Xene-based nanotechnology is currently missing due to the lack of reliable standards for the Xene production and implementation. For this purpose, the proposal aims at developing viable schemes for high-quality crystal growth, environmental stabilization, and device integration of Xenes and XRMs frameworks. At first the effort will be focused on the high-quality synthesis of selected Xenes and XRMs by means of molecular beam epitaxy, and on their stabilization in encapsulated structures enabling subsequent processing into Xene-based device platforms. Validation of the Xene properties, quality, and performances will be carried out by means of advanced in situ and ex situ characterization of the atomic and electronic structure. Secondly, prototypical electronic device (e.g. field effect transistors or vertical diodes) incorporating stabilized Xene frameworks as active elements will be used to assess the Xene electrical behaviour and performances so as to es
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a chp process using grease and oil waste from plants and animals' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

After the dioxin scandal of contaminated chicken from Belgium, the market for the use of these oils for animal food purpose has cracked down. The collectors in EU of used oils actually search valorisation strategies, which are ecologically and economically acceptable. Sud Récupération and AMS wish to develop a new process recycling this waste using the AMS motor technology. Contrary to other technologies, these motors use unrefined plant oils without previous chemical conversion at high eco-efficiency. The Potential is about 1.9 million t of replaced refined fuel. The 2 project partners want to associate other SME to this project. There will be 2700 jobs created in EU. The process contributes to 5.2 % to respect the Kyoto protocol against the greenhouse effect. The project uses the CHP technology on small installations. The motor constructor AMS wishes to find a new combustible, which will help to distribute them also to burn fresh vegetable oil for further reduction of CO2 emissions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Early Multi-Omic Cancer Assessment: eMOCA' under Horizon Europe.

assistant: **Concept**

Lung cancer is a leading cause of cancer related mortality, claiming an estimated 1.8 million lives in 2020. In the EU, lung cancer accounts for 12% of all new cancer diagnoses and 20% of all cancer deaths, Although helpful in identifying early-stage lung cancer, screening programs frequently lead to false-positives and overdiagnosis. This is exacerbated by a lack of clinically useful biomarkers to accurately differentiate between lung cancer and indeterminate nodules found in the lung. Recent studies on lung adenocarcinoma (LUAD) suggest that microbial and host genomic signatures could be leveraged to develop useful biomarkers in early-stage disease. However, these studies are based on systemic signatures identified, using metagenomics, in plasma rather than at the site of the disease, the lung. Very little research has been done on lung squamous cell cancer (LUSC). It is likely that both microbial and host signatures in the lungs of patients with LUSC, a more centrally located cancer, will be more specific and have stronger predictive power as biomarkers. Sampling of the lung is difficult however and involves invasive procedures such as bronchoscopy.  Exhaled breath condensate (EBC) is a novel non-invasive method of collecting lower airways samples, which I will use to evaluate the lung micro-environment in LUSC. Furthermore, microbial RNA sequencing (metatranscriptome) provides broader and more detailed insight into the active function of microbes in different environments, while metabolomics provides further insight into the by-products of microbial metabolism. Applying this unbiased ‘omic approach (metagenome, metatranscriptome, metabolome & transcriptome) to multiple sample types (blood, sputum, EBC & bronchoscopy samples) will allow identification of novel microb