RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Testbeds for Reliable Smart City Machine-to-Machine Communication' (TRESCIMO) targeting Seventh Framework.

assistant: **Abstract**

Smarter and greener cities are essential to address economic, social, and environmental challenges due to the increase in urbanization, requiring informed decisions based on Internet of Things generated data. A particular challenge is the unstable power supply of cities in underdeveloped countries (e.g. South Africa), thus requiring smart energy management. Future handling of grid overload in South Africa involves demand-response mechanisms, installing small devices at the end-user, communicating over different network technologies to a central controller, allowing loads to be measured and limited if necessary. Further challenges are the deployment of affordable smart sensors (e.g. ABS air sensors) as well as gathering information from nodes with limited power. In scenarios from energy consumption to waste bin levels, data is either sent over IP networks (which delivers data immediately) or collected in a delay tolerant mode by mobile devices of individuals or crowds. In delay tolerant mode the data is stored locally, to be delivered when a suitable network is reached. In cases of open data collection the devices in this Future Internet realm are targets of security attacks and might be vendor-locked with proprietary software stacks. Our approach to address these issues is to interweave a sophisticated Smart City Platform (CSIR) and an ETSI/oneM2M compliant Machine-to-Machine (M2M) communication framework (TUB/Fraunhofer OpenMTC) as well as a delay tolerant Smart Platform with the M2M framework. We emphasize secure identification and authentication of sensors and users as well as policy-based store and forward functionality. To validate our approach, we analyse the core developments in federated experimental facilities (testbeds) in Berlin (TUB) and Cape Town (UCT) usin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advancing Safe and Sustainable by design Practices in Pharmaceutical Manufacturing' to be submitted under Horizon Europe.

assistant: **Abstract**

PHARMECO is supported by the Innovative Health Initiative Joint Undertaking (IHI JU). The JU receives support from the European Union’s Horizon Europe research and innovation programme and COCIR, EFPIA, Europa Bío, MedTech Europe, and Vaccines Europe. The project's overall objective is to revolutionize pharmaceutical manufacturing towards sustainability by integrating environmentally friendly technologies/processes and harmonized sustainability assessments methods into healthcare industry practices. This encompasses early design phase, operation, and eventual use and disposal. The project's first objective is to enhance the early-stage development of pharmaceutical products by implementing Sustainable-by-Design (SSbD)-driven process-intensified platforms (e.g. continuous manufacturing). This involves designing sustainable processes based on so-called SELECT (Safety, Environment, Legal, Economy, Control and Throughput) criteria and setting up eco-friendly systems for producing small molecules, peptides, oligo-nucleotides, proteins and ribonucleic acid (RNA) with advanced control measures. Next, PHARMECO aims to scale up and demonstrate environmentally-friendly processes for industrial manufacturing and decontamination, which includes  creating infrastructure for studying key unit operations with sustainable technology and for SSbD-driven process intensified manufacture at a scale sufficient for clinical testing and a manufacturing process that is easily transferred to a Good Manufacturing Practice (GMP) environment. PHARMECO also aims to steer the development of (bio)manufacturing processes towards sustainable production through digital decision-making tools. This involves creating a modular digital tool for assessing sustainability from multiple perspectives, evaluating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Big Extragalactic Surveys Treated Through Innovative MEthods' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

An epoch of “big data” mining just started for high redshift astronomy. State-of-the-art photometric surveys observed millions of objects on sky, and next-generation telescopes will provide statistically significant samples even for the rarest galaxy types. However, standard techniques (e.g., methods to fit galaxies' spectral energy distribution) are not optimal to analyse this data, preventing a true scientific breakthrough. Indeed some of the most urgent questions in this research field, concerning the evolution of rare ultra-massive galaxies, may remain unsolved. As the Cosmic Dawn Center (University of Copenhagen) is collecting an unprecedented large sample of photometric and spectroscopic data, this is the best time to devise new tools for a full exploitation of such unique observations.The proposed project will devise an original machine learning software to efficiently extract information from the Cosmic Dawn Survey database, and an advanced statistical analysis will result in unprecedented demographics (e.g., stellar mass function) of high redshift (z>3), massive (>5e10 Msol) galaxies. By interpreting these measurements through theoretical models, the project will shed light on the physical mechanisms driving star formation in such extreme galaxies, which are thought to contain most of the stellar mass in the early universe. Besides the unparalleled data set, the expertise of S. Toft (host supervisor) and the other members of the Cosmic Dawn Center will be crucial to achieve these goals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The first protoclusters of galaxies: probes of star formation in the infancy of the Universe'.

assistant: **Innovation**

The formation of stars and galaxies in the first billion of years after the Big Bang presents many open questions and opportunities for (unexpected) discoveries. How and when the first stars and galaxies were formed? How do they evolve with time into the galaxies, stars and black holes that we observe today? To address these fundamental questions, we propose to study star formation in the first protoclusters of galaxies during the infancy of the Universe. We started finding these rare overdensities with the Hubble Space Telescope (HST) as early as 650 million years after the Big Bang (at redshift z~8, more than 13 billion light years from us). Now, we aim at characterizing their properties. Our approach is based on combining observations using the most powerful telescopes, such as HST, Spitzer, ALMA, VLT and Keck, with computer simulations and theoretical modeling to interpret the datasets. Protocluster galaxies live in overdense regions with an earlier than average assembly history, hence they are ideal to investigate the very first instances of star formation and cosmic reionization. Our project will (1) characterize galaxies in the most distant protocluster known to date, which we discovered thanks to a large HST campaign; (2) discover new protoclusters at similar redshift in the short term, and out to redshift z~15 (300 Myr after the Big Bang) in the future with the James Webb Space Telescope; (3) model the formation and evolution of these systems across cosmic time, testing not only our understanding of how stars and galaxies are born, but also of the fundamental nature of dark matter particles. The project is based on ongoing observations and modeling started in the United States, and supported by ample NASA funding awarded to the researcher before his reintegrati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Using cis-regulatory mutations to highlight polygenic adaptation in natural plant systems' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The goal of this project is to demonstrate that novel aspects of the molecular basis of Darwinian adaptation can be discovered if the polygenic basis of adaptation is taken into account. This project will use the genome-wide distribution of cis-regulatory variants to discover the molecular pathways that are optimized during adaptation via accumulation of small effect mutations. Current approaches include scans for outlier genes with strong population genetics signatures of selection, or large effect QTL associating with fitness. They can only reveal a small subset of the molecular changes recruited along adaptive paths. Here, instead, the distribution of small effect mutations will be used to make inferences on the targets of polygenic adaptation across divergent populations in each of the two closely related species, A. thaliana and A. lyrata. These species are both found at diverse latitudes and show sign of local adaptation to climatic differences. Mutations affecting cis-regulation will be identified in leaves of plants exposed to various temperature regimes triggering phenotypic responses of adaptive relevance. Their distribution in clusters of functionally connected genes will be quantified. The phylogeographic differences in the distribution of the mutations will be used to disentangle neutral from adaptive clusters of functionally connected genes in each of the two species.  This project will identify the molecular pathways subjected collectively to natural selection and provide a completely novel view on adaptive landscapes. It will further examine whether local adaptation occurs by convergent evolution of molecular systems in plants. This approach has the potential to find broad applications in ecology and agriculture.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'III Researchers in Real Life'.

assistant: **Objectives**

The project “Researchers in real life” will achieve third edition this year, which let us to enhance the experience of previous editions in three main targets: more public attendance to the activities (15% increases to 13.500), more social impact through appropriate awareness campaign and more researchers involved in the project (100% of researchers working in Aragon as potential participant).Esciencia Science Events, which will coordinate this project, will use all tools of success of the first edition. Esciencia is a SME which born a spin-off of University of Zaragoza, and nowadays coordinates similar events. We are aim to Science Communication in innovative ways. This proposal is based in our experience through the last 6 years working for the public at large, with relevant projects in our country and fundamentally in our experience in the coordination of first edition of this project. We create new approaches to the public from Researchers Institutions and placing researchers as main role. In this case, we have the support of the University of Zaragoza, ARAID Foundation and CSIC, these are three relevant institutions related to research and the popularization of science in Aragon.Aragon has a population of 2.000.000 inhabitants, with 700.000 living in Zaragoza the capital city. The economy is agriculture-based and is weak industrialized. So, research and innovation will play an import role in our closest future. There are strong investment programs from local stakeholders to promote research. In previous edition the project found the support of main local institutions. The partner play important role in advertisement, promotional gadgets or locations funding.The activities will make use of previous edition knowledge working with researchers from the very beginning.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Assessing the consequences of global changes for the Barents sea region: the Barents sea impact study', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

BASIS aims to provide an integrated assessment of global change impacts on cultural and socio-economic systems dependent on renewable and non-renewable resources in the Barents Sea region. This main goal is going to be addressed through the following objectives: (i)BASIS will assess the likely magnitude of global changes on regional to sub-regional scales in the Barents region. (ii) BASIS is going to provide insight into the consequences of global changes for terrestrial, freshwater and marine ecosystems. (iii) BASIS aims to develop an integrated assessment of global change impacts for a number of major economic sectors (fishery, forestry, reindeer herding) in the Barents region. (iv) BASIS will determine major changes in the socio-economic structure of the Barents region and will detemmine the conditions for a sustainable development in the region under conditions of global change. Thus, BASIS addresses both impacts of global changes on the environmental and societal level within a 20 to 50 years time frame in the Barents region. We explicitly do not limit our considerations to climate change alone and will also include the impacts of contaminants on the region. Research activities embrace and combine: extensive base case studies in relevant sectors on both levels, biological and hydrological field work, the modelling of major environmental (marine) and socio-economic processes and the generation of predictive scenarios of development under conditions of global change. An important element of the study will be a dedicated, collectively accessible (via the Internet) data base and GIS infrastructure, which will also be open to other interested parties. The infommation and consultation of local and indigenous stakeholders and their feedback with regard to the implementati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A genetic engineering approach for Lignification of cell walls from Moss to develop novel wood-like biomass.' in the context of a Horizon Europe call.

assistant: **Objectives**

In the current context of climate change, transitioning from a petroleum-based economy to more sustainable alternatives is of top priority. Wood is one of the most abundant renewable resources with established roles in the furniture, construction, paper and energy sectors. Because of this, demand for wood is increasing as policies around the world promote energy generation from wood, risking increased deforestation and exchange of diverse forests for monoculture plantations. The industrial applications of wood depend on its composition, specifically that of lignin in the secondary cell wall (SCW). Although much is known about lignification through extensive research on Arabidopsis thaliana and other vascular plants, there are still knowledge gaps involving the initiation and control of lignin polymerization that remain to be addressed in order to outline the core set of genes associated  with the emergence of lignin.In these lines, the long-term goal of this proposal is to engineer innovative wood-like biomass by introducing lignin-biosynthetic genes in fast-growing moss to establish new types of biomaterials, potentially reducing the use of wood in certain applications and alleviating increasing pressures on forests.Mosses are land plants lacking lignified vascular tissues but have homologous genes to most steps in lignin biosynthesis. We hypothesize that the lack of lignin in mosses makes them potential model systems to determine how lignin polymerization and SCW formation occur in plants.In this proposal, we will systematically transform the model moss Physcomitrium patens, with genes from vascular plants until canonical lignin is observed in its cell wall. The outcomes of this work will pave the way for innovative biomass sources and potentially provide insights int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Computational design of novel protein function in antibodies' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

We propose to elucidate the structural design principles of naturally occurring antibody complementarity-determining regions (CDRs) and to computationally design novel antibody functions. Antibodies represent the most versatile known system for molecular recognition. Research has yielded many insights into antibody design principles and promising biotechnological and pharmaceutical applications. Still, our understanding of how CDRs encode specific loop conformations lags far behind our understanding of structure-function relationships in non-immunological scaffolds. Thus, design of antibodies from first principles has not been demonstrated. We propose a computational-experimental strategy to address this challenge. We will: (a) characterize the design principles and sequence elements that rigidify antibody CDRs. Natural antibody loops will be subjected to computational modeling, crystallography, and a combined in vitro evolution and deep-sequencing approach to isolate sequence features that rigidify loop backbones; (b) develop a novel computational-design strategy, which uses the >1000 solved structures of antibodies deposited in structure databases to realistically model CDRs and design them to recognize proteins that have not been co-crystallized with antibodies. For example, we will design novel antibodies targeting insulin, for which clinically useful diagnostics are needed. By accessing much larger sequence/structure spaces than are available to natural immune-system repertoires and experimental methods, computational antibody design could produce higher-specificity and higher-affinity binders, even to challenging targets; and (c) develop new strategies to program conformational change in CDRs, generating, e.g., the first allosteric antibodies. These will allow tar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Optimizing water quality and treatment efficency in recirculating aquaculture systems for salmon smolt production through better adjustment of fish feed and water treatment devices' (2007-2013).

assistant: **Innovation**

The project target, is to improve the system performance of recirculating aquaculture systems for salmon smolt production by improving the treatability of the fish excrements and improving the treatment devices. The idea is to have a better tuning/adjustment between the feed as the only main input into a recirc. system and the water treatment as warrantor for the water quality and for the fish and system performance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A European joint programming initiative to develop integrated, regional, smart energy systems enabling regions and local communities to realize their high sustainable energy ambitions' (2014-2020).

assistant: **Innovation**

The action will set up a joint programming initiative to develop Smart, Integrated, Regional Energy Systems that enable regions and local communities to realize their high ambitions of moving towards decarbonised energy systems and at the same time link them to a secure and resilient European energy system. This shall include solutions that allow for a high proportion of renewables up to and beyond 100% in the local or regional supply. The initiative will coordinate relevant RDD programs in the involved European, associated countries and regions represented in the consortium connecting them with other funding and financing partners. It will accelerate the deployment of latest resource-efficient and decarbonising energy system solutions, thus strengthening the competitiveness in relevant markets and lerveraging sustainable structures already established by ERA-Net Smart Grids Plus . The latter is focussing on the broad involvement of a large number of countries and regions in order to implement European smart electricity grids research agendas, while the ERA-Net SG+ RegSys will build on this with a new approach, developing integrated, regional energy systems, including the full spectrum of energy carriers and infrastructures. A highly ambitious consortium will pilot new formats of collaboration with regional and local stakeholders as well as supply and demand side oriented technology policy.


**Keywords:** Smart Grids, Energy Systems, Energy Solutions, Regional Energy Networks, Heating Networks, Cooling Networks, local utilities, start-ups