RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Towards the optimization of hydrogen production by nitrogenase' (TOHPN).

assistant: **Innovation**

In nature, molecular hydrogen is produced by the hydrogenase and the nitrogenase enzymes. Nitrogenase reduces dinitrogen to ammonia and, in this process, it evolves hydrogen. Nitrogenase and hydrogenase are oxygen-sensitive enzymes. We chose to optimize a hydrogen production system based on nitrogenase for four reasons: some organisms carrying nitrogenase simultaneously perform photosynthesis and hydrogen evolution by nitrogenase (direct biophotolysis), thus harvesting solar energy and autonomously converting it into chemical energy in a continuous process; cellular mechanisms exist to protect nitrogenase from oxygen but do not appear to exist for hydrogenase; because nitrogenase couples ATP hydrolysis to hydrogen evolution, this enzyme is able to generate hydrogen against a substantial gas pressure; finally, the biochemistry of the nitrogenase system is well known. The objective of our proposal is to provide new eco-efficient strategies for the biological production of hydrogen. Energy research is a priority theme under the Seventh Research Framework (FP7) cooperation program. The objective of energy research under FP7 is to adapt the current energy system into a more sustainable, competitive and secure one, with emphasis and support given to hydrogen research and renewable fuel production. Our proposal has three major components: (i) in vitro evolution of nitrogenase, in which we generate new nitrogenase variants by metagenomic gene shuffling and random mutagenesis, and select those with increased hydrogen production activity; (ii) the development of a genetic system to select for hydrogen overproducers; and (iii) a biochemical element designed to understand the biochemical requisites for efficient hydrogen production by the molybdenum nitrogenase as a basis for its r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Engineering of the porcine genome for xenotransplantation studies in primates: a step towards clinical application'.

assistant: **Objectives**

The ultimate goal of our Consortium is to generate the necessary data to allow xenotransplantation to progress towards its initial clinical phase. The data generated during this project will encompass both efficacy and safety aspects of xeno-transplantation. Tools that will be used to reach this ambitious objective encompass state-of-the-art biomolecular technologies and in vivo models. XENOME aims to produce a super-engineered" pig, i.e. a pig with a newly generated genotype that will improve the efficacy and safety profile of xenotransplantation. Assessments of efficacy will first take advantage of existing pig lines expressing human complement regulators, thrombomodulin (TM) and knock-out for a-Gal transferase. Using the most suitable background, further engineering will eliminate one or more PERV sequences. Additional transgenes, such as HO-1, CD39 and other molecules able to control immune responses, endothelial cell activation and subsequent microangiopathy, will be added.The ultimate pig strain will thus combine the already available background with novel molecules exhibiting anti-inflammatory, anticoagulant and immunosuppressive properties. In addition, an effective immuno-suppression regimen will be defined and new pharmaceutical agents will be tested. A strong safety framework will also be established that may allow, at some stage, progression of xenotransplantation into the clinic. This will involve development of technologies enabling the timely diagnosis of infection, design of a safety plan for an efficacious containment of an untoward infectious event, breeding of a herd of "clean" source pigs, inactivation of PERV sequences and provide safety-related data deriving from long-term in vivo studies in primate xenograft recipients. Finally, the project will a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Power, Politics and Contestation in Global Technical Standard-Setting' to be submitted under Horizon Europe.

assistant: **Abstract**

The governance of global technical standard-setting is in the midst of unprecedented transformation and contestation. Long dominated by wealthy industrialized countries, international standardization organizations have been shaken by the emergence of rising standards powers, above all China. Alongside China, several other Global South countries are now breaching the high barriers to entry in this field.TECHtonics will contribute two theoretical innovations addressed to both the international standardization literature and scholars of global governance more broadly. One aim of the project is development of a framework to study how and why some developing countries manage to acquire standards power, against the odds. A second contribution is introduction of the concept of governance rupture to study the multifaceted forms of contestation unfolding in global technical standard-setting. Since both topics addressed by these frameworksinstitutionalized inequality and complex governance challengesare not unique to technical standard-setting, the findings will advance theory-building on power, politics and contestation in the global governance literature. The project employs mixed methods to provide empirically rich, granular analyses of rising standards powers and governance ruptures in international standardization. One work package features case studies of rising standards powers at different levels of influence in international standardizationaspiring (Kenya), rising (India) and risen (China). A second work package will study the dynamics of governance rupture in global digital standard-setting unfolding across four theatres: power, practice, authority and bloc formation. TECHtonics will directly transfer insights to the practitioners world. A practitioner lab and secondmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Cluster-Galaxy Connection: Interactions and Evolution' (TCGCIEIS).

assistant: **Concept**

In the Universe, structure is formed hierarchically, by the merging of smaller units. Large clusters of galaxies are formed by the continual falling of galaxies into the clusters. The interactions of the cluster gas with the moving galaxies modify the pro perties of both galaxies and clusters by, for example, stripping the galaxies, and heating the cluster. These modifications have an impact on their subsequent evolution.I am proposing to combine my existing expertise in the analysis of X-ray data from evol ving and merging clusters of galaxies with MPIA's experience on deep galaxy surveys and galaxy dynamics in order to get a better insight into the factors that control the evolution of galaxies and clusters, and the impact of galaxy-cluster interactions. Su ch a combined study has not been done yet; it is timely, because of the availability of high quality X-ray data from the new satellites Chandra and XMM, and the wealth of ongoing deep galaxy surveys that are producing encouraging results.The properties of the clusters will be derived from the X-ray observations, while optical/infrared data will be used to find the galaxy characteristics. Appropriate methods for the handling of the X-ray and galaxy survey data have been developed and used by me and MPIA res pectively over the past years. Data already exist and the samples will be complimented when necessary by data from the rapidly expanding archives and/or after the submittion of proposals. My training will be on the use of large galaxy survey data, how to extract the essential information, and combine it successfully with the X-ray data. I also expect to gain a deeper knowledge on galaxy dynamics and galaxy interactions by being at MPIA.At the end of the project I will be able to assess the importance of ga laxy-c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Statistical physics of immune-viral co-evolution'.

assistant: **Concept**

The immune system within each individual host destroys viruses, which manage to escape immunity on the global scale. Recent experiments show population-level responses of both immune repertoires and viruses, and a history dependence of their functional phenotypes. This constrained long-term co-evolution of immune receptor and viral populations is a stochastic many-body problem occurring at many scales, in which the response emerges based on the past states of both the repertoire and viral populations. STRUGGLE infers the details of viral-immune receptor interactions from functional datasets to obtain a predictive statistical model of co-evolution between immune repertoires and viruses.STRUGGLE covers the many scales of immune-virus interactions: from the molecular level, analyzing high-throughput mutational screens of libraries of antibodies binding a given antigen, through the population-level response of immune repertoires, analyzing next-generation sequencing of vaccine-stimulated whole repertoires, to the population level, modeling the long term co-evolution of both repertoires and viruses.STRUGGLE combines a statistical data analysis approach with cross-scale many-body physics to: - build a molecular model for antigen-receptor binding;- learn statistical models for repertoire-level response to viral antigen stimulation;- validate dynamical models of interactions between antigen and immune receptors;- theoretically evaluate the predictive power of the immune system and viruses;- and predict virus strains and immune responses based on past infections.The outcomes of STRUGGLE include the quantitative characterization of the human T-cell response to flu vaccines, with implications for vaccination strategies, and the trout B-cell response to life-threatening rhabdovirus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Treatment of contaminated land using a biochar/media mixture' (TOOLBOX).

assistant: **Concept**

Waste disposal and treatment is a major source of contamination of soils, surface and groundwater, and accounts for 35% of the 1.1 million contaminated sites in Europe. Leaching of the organic solvent trichloroethylene (TCE) into groundwater has been identified as a primary issue with unlined landfills , affecting up to 70% of leachates tested. Mainly used as a metal degreaser and dry-cleaning reagent, TCE is difficult to treat; current treatment methods, such as anaerobic digestion  or air stripping , are ineffective and/or expensive. This project will investigate the use biochar, or other appropriate media, for treatment of TCE contaminated water via two technologies - permeable reactive interceptors (PRIs) and permeable contaminant retaining filter (PCRF) bags. This novel, low-cost solution will address the requirements of European Union (EU) legislation, including the Water Framework Directive (WFD). The project will be based at the National University of Ireland, Galway (NUIG) with supervision by Dr Mark Healy (GeoEnvironmental Engineering Research Group – GENE) and support from Dr Florence Abram (Functional Environmental Microbiology - FEM). As the applicant has experience in TCE treatment from a microbial background, this highly novel, interdisciplinary proposal will compliment and strengthen her existing skillset by approaching this technology from an engineering perspective, with support from a research group that has a strong track record in this research area. With detailed career development assistance, multiple opportunities to further her strong publication record, access to numerous and varied fora for dissemination of results and support for IP exploitation, this proposal will have a significant impact in reintegrating the applicant back into the EU rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enabling kNowledge Sustainability Usability and Recovery for Economic value' in the context of a Seventh Framework call.

assistant: **Objectives**

Ensuring long term usability for the spiraling amounts of data produced or controlled by organizations with commercial interests is quickly becoming a major problem.  Drawing on motivation from uses cases in aerospace, health care, finance and clinical trials, ENSURE will significantly extend the state of the art in digital preservation which to-date has focused on relatively homogeneous cultural heritage data.  Our use cases bring up a large number of issues which have yet to be fully addressed:  1) safely leveraging scalable pay-as-you-go infrastructure such as clouds 2) having businesses understand the economic implications of preservation, 3) conforming to regulatory, contractual and legal requirements as part of a whole workflow 4) managing long term integrity and authenticity significant intellectual property or highly personal data and 5) using off-the-shelf IT technologies for preservation to support different types of digital resources.<br/>Building on prior work, ENSURE will address these issue with innovative approaches and tools:\tCost and Value Evaluate the cost and benefit of different quality solutions.\tPreservation Lifecycle Management Build on industry standard lifecycle management approaches to manage the preservation lifecycle, ensuring regulatory compliance, allowing changes in the preservation approach to reflect environmental changes, addressing evolution of ontologies and managing the quality of the digital objects over time.\tContent-Aware Long Term Data Protection Ensure long-term, content-aware data protection, addressing changes in personally identifiable information,  new and evolving regulations, managing user identities over decades, etc.\tLeveraging Wider ITC Evaluate the costs/risks/benefits and demonstrate how to use emerging, commo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'EXPRESS 2 SPECIFY AND PROTECT THE EU SOCIAL CONTRACT (EXPRESS2)' (EXPRESS2), addressing dissemination and exploitation.

assistant: **Impact**

EXPRESS2 is a project that addresses from a multidisciplinary, interdisciplinary and cross-sectional perspective, the growing demand for a new, more democratic, inclusive, and sustainable social contract in the EU. To achieve this, the project will work to create a more appealing and legitimate EU social contract draft that will be submitted to inhabitants, Member States and EU institutions that will have the possibility to participate and decide upon the conditions, rights, and obligations to be binding. The goal is to strengthen the EU agreement of association by promoting social dialogue, civic engagement, and integration. An express draft shall be achieved by means of policy dialogue, campaign implementation, collaborative workshops, advocacy planning, and innovative offline and online formats and tools to create spaces for dialogue. To this end, EXPRESS2 will involve EU policymakers and institutions throughout the project to obtain a more appealing and legitimate EU social contract draft. The project will also focus on identifying and analyzing disruptive elements of the social contract, such as insecurity, populism, climate change, mistrust in institutions, gender discrimination, digitalisation and pandemics. The analysis of these stressors includes both individualised and cross-sectional approaches to cover the plausible relation of multiple disruptors, their concatenation or the “trigger” effect of a disruptive phenomenon to another. By understanding these disruptive elements and their effects on the social contract, the project will propose concrete measures to ironclad the social contract and it will provide relevant information to protect it from actual and potential disruptions thus we conceive social contracts as incomplete theorised agreements and living d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'MEASURING ENERGY TRANSITION (ET) RISK FOR INVESTORS: DEVELOPING AN ENERGY TRANSITION ASSESSMENT FRAMEWORK FOR EQUITIES AND BONDS'.

assistant: **Innovation**

The transition to a low-carbon economy creates financial risk and opportunities. A key barrier for investors in responding to this risk relates to the shortcomings of the current landscape of asset valuation and credit risk models in capturing this financial risk and opportunity. The objective of the project is to develop an Energy Transition (ET) risk and opportunity assessment framework. The objectives of this framework are to help investors and policy makers understand the materiality of energy transition risk and opportunity, help investors assess this materiality for bond and equity portfolios, and engage with investors & policy makers on responding to these risks in order to mobilize capital for sustainable energy investment. The activities focus on seven key industries. The core focus is on building bottom-up databases, Energy transition risk and opportunity scenarios net margin impact models. These outputs will then feed into newly developed equity valuation (developed by Kepler-Cheuvreux) and credit risk models (developed by S&P Capital IQ). The project enables investors and analysts to implement these models into their investment decision-making, either through the assessment framework or directly equity and bond indices developed in the course of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Variability of the glacial and interglacial climates and abrupt climatic changes' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

To document the variability of the glacial and interglacial climates and determine the major mechanisms responsible for this variability. Precise 14C AMS dating, isotopic, geochemical, sedimentological, sediment magnetism and micropaleontological  data will be generated in a series of deep North Atlantic sediment cores. This data set will provide a detailed  reconstruction of the oceanic record of major examples of abrupt climatic changes, typical of the variability of  the glacial and interglacial climates.  The glacial examples to be investigated are two of the massive iceberg discharges, leading to major perturbations  in the oceanic salt budget, which occurred during the last glaciation. Another case to be investigated is the  succession of climatic events which occurred during the last interglacial. This study will address the issue of  the stability of interglacial climates and the impact of the early cooling of the Norwegian-Greenland Sea (that  weree recently discovered) on the oceanic and atmospheric circulation.  To interpret the obtained reconstructions, several numerical experiments will be performed using 3-D general  circulation models of the atmosphere and the ocean, run first in a forced mode and then fully coupled. These  experiments, together with those performed with simpler models, should allow a better understanding of the  feedbacks internal to the climate system (including the behaviour of the ocean and the CO2 cycle) and which  are responsible for rapid transition from one climatic state to another. In addition, transient experiments will  be conducted with 2-D coupled models of the climate system, helping to identify the role and potential  importance of specific physical processes and components of the climate system for climatic changes.  The