RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'RESEARCHER'S NIGHT IN LATVIA'.

assistant: **Objectives**

The main objective of the Projectis to raise the awareness of the larger public, especially young people, about science as well as to familiarize them with the scientist’s profession; to show the impact of sciences such as astronomy, chemistry, medical science, and physics on everyday human life; to show researchers as ordinary people; to bring researchers closer to the Latvian society and to attract young people to research careers. Aim of the activities is to enhance public recognition of researchers and their role in Latvian society. The theme of the Researcher's Night in Latvia is “Stars in our lives”. The theme will not be strictly followed. A number of relaxing, attractive, amazing and interactive events will be organised in fīve towns - Riga, Daugavpils, Rezekne, Jelgava and Ventspils. The project will be realised by joint efforts of the Latvian Academy of Sciences, 4 Universities, and research institutes with participation of museums and library. The Researchers’ Night will be preceded by a promotion campaign in mass media. The scope of activities will include a poster competition among children and adults, establishing a European stand, organising a Café Scientifique; a concert with participation of musicians – researchers; scenic play performed by researchers; public meeting with Marie Curie scholarship holders; arranging a series of events with scientific interactive experiments and quizzes in research institutes and universities. An opinion survey will be performed to size up the viewpoints of public on the event and researchers’ profession. The opinion poll results and analysis of Internet comments on the event will allow to evaluate the impact Researchers’ Night and collect ideas for future activities. The event will be documented in video-film for demonst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Including Responsible Research and innovation in cutting Edge Science and Inquiry-based Science education to improve Teacher's Ability of Bridging Learning Environments' (IRRESISTIBLE).

assistant: **Innovation**

IRRESISTIBLEIn the project IRRISITIBLE partners work together to make young people more aware about Responsible Research and Innovation issues. Universities and science centres will cooperate in the project using the expertise they have in linking formal land informal learning.For a long term effect the project focusses on teacher training. Each partner will form a Community of Learners in which teachers work together with formal education experts and informal education experts. The topics they will work on are derived from cutting edge research taking place at the partners’ university. Researchers and people from industry will complement the Community of Learners.The Community of Learners will develop material to be used both in the classroom as well as in the science centres. During the first part content knowledge about the research will be introduced using the well established IBSE methodology. In the second part students will discuss and work on Responsible Research and Innovation issues regarding the research they have studied. Each partner will develop one module to be used in the classroomDuring the module students will be developing exhibits about the RRI issues that they have studied. These exhibits will be presented in the science centres.The best exhibits from each partner will be brought together during the yearly conferences of the project. By using new techniques like digital fabrication (ie. 3D printing) the exchange of exhibits will be easy between partners.In the second round of the project the teachers from the first Community of Learners will work in a new Community with 4 to 5 new teachers. They will help these teachers introduce the developed modules in their own classroom. This way the number of teachers involved grows.After receiving feedback fro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Light microscopy infrastructure' under Fifth Framework.

assistant: **Concept**

Description:The European Advanced Light Microscopy Facility at EMBL provides access and support in state-of-the-art light microscopy techniques and their biological applications. Commercially available equipment-provided by leading companies in the field-and novel techniques developed by EMBL scientists are offered by this infrastructure. The main techniques available are single, two photon and theta confocal microscopy, photonic microscopy, fast 3D sectioning, time-lapse fluorescence microscopy, image analysis and restoration, computer automated microinjection, and single cell and tissue micro-manipulation devices. During their stay, visitors are fully integrated in the EMBL scientific environment. The total amount of access offered by the infrastructure during the funding period will be 4500 hours for about 50 users from all over Europe.Application:Project Manager:Christian Boulin, Cell Biology and Biophysics Programme, Meyerhofstrasse 1, Heidelberg 69012, P.O. BOX 102209, GermanyTel: +49-6221-387350Fax: +49-6221-387242E-Mail: boulin@embl-heidelberg.de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Potential Antimalarial and Anticancer Lead Compound Discovery from Cameroonian Medicinal Plants', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Cameroon enjoys a rich biota including a plethora of medicinal plants, which have traditionally been used for hundreds ofyears to treat various ailments, and form the basis of the country’s primary healthcare system. Medicinal plants of thegenera Fagara (F: Rutaceae), and Hannoa and Pierreodendron (F: Simaroubaceae) belong to the Cameroonian flora, andare used by the local people to treat malaria, cancer, rheumatism, bacterial infections, pain, inflammations, typhoid, skininfection and other serious disorders. Previous studies carried out on certain species of these genera afforded variousphytochemicals (quassinoids, furoquinoleine, acridones, cathinone alcaloids, triterpenoids and steroids) and revealedinteresting pharmacological properties (cytotoxicity, antiplasmadial activities). This project proposes to employ acombination of chemical fingerprinting-based dereplication, assay-guided fractionation and reversed-phase preparative highperformance chromatographic methods to identify potential anticancer and antimalarial lead compounds from plants of thegenera mentioned above, selected on the basis of ethnobotanical information as well as literature data. The structures ofthe isolated compounds will be elucidated by spectroscopic means (UV, IR, MS, NMR and X-ray). Structural modification toincrease activity of compounds will be carried out applying modern semisynthetic approaches in order to establish structureactivityrelationships. Total synthesis will also be carried out to increase to quantity of the lead compounds. Suitable in vitrobioassays, relevant to cytotoxicity, antimalarial and toxicity determination will be utilised to aid isolation processes as well asfor the determination of bioactive potencies of the isolated lead compounds. The main objective is to discov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exoribonuclease-mediated degradation of nascent RNA in Malaria Parasites: A Novel Mechanism in Virulence Gene Silencing' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Background: The human protozoan malaria parasite P. falciparum causes approximately 200 million infections and 0.7 million deaths (mainly children) per year. In the well-studied asexual blood stages, cyclic monocistronic gene activation occurs at the transcriptional level; however, relatively few transcription factors have been identified, thus other types of regulatory processes that contribute to this coordinated gene expression are believed to exist. Through the study of molecular process of monoallelic expression of immune evasion genes in P. falciparum (project funded by a previous ERC grant to A. Scherf), we discovered an entirely new mechanism of gene silencing. We demonstrated that an exoribonuclease silences genes linked to severe malaria. A non-canonical 3’-5’exoribonuclease termed PfRNase II destroys nascent RNA made from promoter regions, leading to cryptic unstable mRNA. Parasites carrying a deficient PfRNase II produce full-length mRNA and long noncoding RNA. The molecular events and the number of genes directly controlled by this novel type of posttranscriptional gene silencing remain elusive. Aim: This proposal aims to investigate the molecular mechanisms controlling PfRNase II-dependent gene silencing using innovative strategies such as the new genome editing technique (Cas9/CRISPR) developed in my laboratory for use in P. falciparum. We will study i) the recruitment of PfRNase II to promoter regions of severe malaria related genes using protein pull-down assays and ii) the genome occupancy of PfRNase II and two other 3’-5’ exoribonucleases to determine the total number of genes controlled by this mechanism.Impact: This project represents a major change in mainstream malaria parasite gene regulation paradigms with repercussions for other organisms. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Molecular Plasticity of Inhibitory Synapses'.

assistant: **Innovation**

Neurons maintain a precise organization of their membrane into sub-domains with specific molecular compositions, together with the capacity to change it in response to plasticity events. However, as seen with the tracking of single molecules, receptors in the plasma membrane continuously exchange between synaptic and extrasynaptic locations. Interactions between neurotransmitter receptors and postsynaptic scaffold proteins control the distribution of receptors at synaptic and extrasynaptic sites. This mechanism is modulated at many levels, and contributes to the regulation of the synaptic strength of excitatory and inhibitory synapses in physiological and pathological conditions. This project will address the gap in knowledge between the molecular instability of randomly diffusing receptors and the stable functional architecture of synapses. It will provide new insights into fundamental issues related to the cellular basis of neuronal information processing. Focusing on inhibitory Glycine and GABAA receptors (GlyR, GABAAR) I will have 3 main objectives:Objective 1: to determine key aspects of the relationship between the synapse microstructure, molecular dynamics, and molecular interactions.Objective 2: characterize the mechanisms by which receptor diffusion contributes to the adaptation of inhibitory synapses to excitatory activity.Objective 3: understand how non-neuronal glial cells modulate inhibitory receptor diffusion-trapping and ultimately impact on neuronal excitability.For this research, single molecule methods and super-resolution microscopy give access to molecular dynamics (tracking), the morphology at high resolution, and quantitative data such as dwell times and absolute numbers of molecules, thus identifying new cellular mechanisms accounting for the regu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Solar thermal and long term heat storage for district heating systems'.

assistant: **Objectives**

The project aim to demonstrate:-how 30% of the demand for heat in a district heating system may be covered by solar heat with the same profitability which has so far been covered by 10-20%. In doing so, the European market for large scale plants will be doubled.-a long term (pit heat) storage which would be constructed for half the costs of steel tanks. The storage might be used as a seasonal heat storage which would further increase the solar fraction.-a solar collector field constituting at least three types of the most efficient solar collectors for solar heat centrals in Northern Europe.-integration of solar heating in a conventional district heating system. Solar fraction 30%. Price of energy 0.045 EUR/kWh.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modeling the perturbational gradients of the human brain' in the context of a Horizon Europe call.

assistant: **Objectives**

Studying the brain mechanisms behind consciousness is a major challenge for neuroscience and medicine. Accumulating evidence shows that the structural, histological, functional, genetic, and neurochemical inhomogeneities of the mammalian cortex do not follow a modular distribution; instead, these properties change following gradients, understood as axes of variance along which cortical features are ordered continuously. The gradient describing the axis of largest variance (principal gradient) obtained for an ample range of cortical features follows a unimodal-transmodal organization, ranging from externally-oriented sensory and motor regions to multimodal association regions, culminating in regions linked with internally oriented higher-order cognitive functions. In this project we propose a novel approach, constructing, validating and exploring whole-brain computational models combining empirical information including anatomical connectivity, spatial maps of local neuroanatomical features, to reproduce the configuration of human functional gradients, as determined using manifold learning techniques applied to functional magnetic resonance imaging (fMRI) data. This will allow us to investigate the process by which functional gradients emerge from the spatial distribution of cortical anatomical inhomogeneities. The models will also provide the possibility to investigate how different global brain states behave under perturbations. In order to achieve our goals, we propose a highly interdisciplinary project that combines state-of-the-art principal gradient expertise with whole-brain computational modelling proposing a synergy between two groups with large expertise in each area to address a common question: do realistic functional gradients emerge from the dynamical equat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Integrated Fire Management System' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The nowadays worldwide wildfire context is defined by extreme fire behaviour characterised by rapid fire spread, intense burning, and unpredictable shifts causing enormous socio-economic impacts. Problems that faced firefighters are: unreliable early-time fire detection tools; unpredictability of fire ignition and unpredictable behavior of fire. S2IGI is a end-to-end Decision Support System (DSS), that aims to support actions in the three main phases of fire management -1. forest fire prevention and mitigation, 2. event management and 3. post-fire recovery. S2IGI through satellite images, in-situ ancillary data and weather numerical predictions, assures timely and reliable fire forecast information. The principal S2IGI target market are public administrations responsible for fire monitoring, prevention, management and damage mitigation; privates as insurance companies and financial entities are also potential customers. S2IGI was developed by Nurjana Technologies in collaboration with CNR-IBIMET the Aerospace Engineering School of the Sapienza University of Rome (SIA). Nurjana Technologies provides expertises in systems development, real time applications/simulations and programs management for Defense, Aerospace and Space market through a Customer Integrated Project Team approach. The objective of the present project is to prove the commercial potential of the S2IGI system in Europe and worldwide, enhance its growth potential and favors private investment opportunities. 30% of the project cost will be financed by the company own capital. The revenue model is based on annually recurring revenue, which favors customer loyalty and service scalability. S2IGI is distributed as a Software as Service (SaaS). The feasibility assessment will be carried on EU (Mediterranean, Bal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The International Dimensions of Authoritarian Rule' (IDAR), addressing dissemination and exploitation.

assistant: **Impact**

This project examines the international dimensions of transitions to and consolidation of authoritarian rule. The need for greater theoretical focus on the sources of authoritarian politics reflects the enduring power and influence of non-democratic regimes in an increasingly democratic world. However, while recent scholarship has sought to conceptualise and explain the enduring patterns of authoritarianism, the existing literature in this field has focused almost exclusively on domestic-level politics, and has marginalised international-level factors.Building on the expertise of the Principal Investigator in the international politics of regime change, this project will overturn existing understandings and will create a new agenda for future research by providing a dedicated and comparative analysis of international dimensions of authoritarian rule that rests on the systematic study of a wide range of quantitative and qualitative evidence by an integrated team of specialist researchers. The project will involve an innovative multi-method research design that combines advanced quantitative techniques (to assess the international influences on regime duration over time) with rigorous case study analyses (to identify the causal mechanisms linking international variables to domestic authoritarian politics).The four-year project will help establish a new scholarly community with a common intellectual focus, which will collectively pioneer a new agenda for research into the international politics of authoritarianism. The overall project team will be comprised of the PI, one full time-time post-doctoral research fellow, two full-time doctoral students, a part-time doctoral research assistant, and the partial involvement of Dr Jonathan Glub from the University of Reading. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nano-OptoMechanical Systems for Biological Sensors' (NOMBIS).

assistant: **Innovation**

The emergence of antibiotic resistance is one of the major challenges in microbiology and medicine today. Early identification of the pathogens causing an infection and the rapid identification of antibiotic resistance is critical to provide the most effective drugs to the patient and to avoid costly and inefficient treatments that can potentially lead to the development of further resistances. This project proposes application of nano-optomechanical disk resonators to face this challenge. We expect to achieve ultra-sensitive and ultrafast gene-based pathogen detection with subzeptogram (10-21g) mass resolution, beating current techniques. The development of arrays of 100s of microdrum devices per chip will weigh complementary DNA strands to those immobilized on the microdrum surface, so tens of different pathogens in a sample can be identified, along with antibiotic resistances, which are also marked by mutations. The devices will be challenged with a proof-of-principle application to identify sepsis-causing pathogens from blood samples and their resistance to the most commonly used antibiotics. The proposed devices provide a large binding area to reduce the analysis time while preserving extreme sensitivity, down to a few biomolecules (DNA strands). We will be able to screen for tens of different pathogens per chip, with sensitivity good enough to target early infection stages from a standard blood extraction. This multidisciplinary and intersectorial project promotes the collaboration of well-recognized academic research groups expert in the optomechanics field and in the development of novel biosensing tools, a clinical laboratory and an industrial partner, pursuing to generate greater economic and social impact; as well as a highly effective training program for th