RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Network of Leading Ecosystem Scale Experimental AQUAtic MesoCOSM Facilities Connecting Rivers, Lakes, Estuaries and Oceans in Europe and beyond'.

assistant: **Concept**

AQUACOSM-plus advances European mesocosm-based aquatic RI by integrating the leading mesocosm infrastructures into a coherent, interdisciplinary, and interoperable network covering all ecoregions of Europe. AQUACOSM-plus widens the user base by extending TA provision (> 13000 person-days), and strengthening the offered services, with 10 new partners, including a NGO and doubling of SMEs. We initiate actions to increase competence in mesocosm science in new EU member states (Hungary and Romania), and emphasize training of young scientists through summer schools covering various disciplines including effective science communication. AQUACOSM-plus develops near-real-time Open Data flows and improved metadata, thus promoting Open Mesocosm Science in collaboration with leading EU-supported initiatives in the EOSC and fosters wider sharing of information, knowledge, and technologies across fields and between academia, industry, and policy makers/advisers.AQUACOSM-plus develops new technological capabilities for mesocosm research, to effectively execute scenario-testing for Climate Change -related pressures on aquatic systems from upstream fresh waters to the sea. These developments include mobile large-scale mesocosm approaches, leading-edge imaging technologies, and affordable methods to obtain high-frequency data on community change and greenhouse gas fluxes in mesocosm settings.AQUACOSM-plus will progress beyond current achievements by actively pursuing RI-RI collaboration with European environmental RIs (LTER, ICOS, DANUBIUS, JERICO) at all project activity levels (NA, JRA, TA). Multidisciplinary joint research, combining observational data and modelling approaches with targeted mesocosm experiments, is a key step towards successfully tackling current and future Grand Cha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Generating an integrative plant science' (GIPS).

assistant: **Innovation**

The next stage in bioscience research requires the combination of skills in wet" experimental approaches and "dry" computational biology. This integrative biology allows the generation of in silio models based on large- scale quantitative data which can be used to inform further experimentation. In Sheffield, the plant science group has international-level ability in the experimental approaches but lacks expertise in computational biology. The aim of this proposal is to acquire these skills and to generate an integrative plant biology. This aim will be achieved by 4 TOK Fellows with complementary skills in the quantitative analysis of growth, modelling, the integration of genomic-scale data and teaching. This will enable the group to maintain an international level of competitiveness and facilitate the transfer of basic scientific knowledge into crop science, a key objective of the EU.In addition, since the acquired skills in computational biology are highly transferable they will enable the generation of a new cadre of young biologists with broad skills in integrative biology. A key objective of this project is the generation of teaching modules which will be delivered by the host department to a large number of undergraduate, PhD student and post-doctoral workers in biology. The production of a pool of trained graduates in integrative biology is required for the exploitation at both academic and commercial level of the advances being made in bioscience research. This will not only benefit the local less-favoured region of South Yorkshire (where bioscience has been identified as a key facilitator of economic renewal) but also provide a stream of highly qualified bioscience researchers for the ERA."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Modular Smart System for Infants' Rehabilitation At Home based on Mechatronic Toys' (CareToy) targeting Seventh Framework.

assistant: **Abstract**

Stroke and other neurological conditions affect the population of infants in percentages that cannot be considered marginal. Preterm infants are the highest infants at risk for neurological damage. Currently, infants have rehabilitation sessions few times a week in rehabilitation centres but according to basic neuroscience it would be necessary to provide them with an early, intensive and multiaxial intervention. One option to reduce the cost of the entire European Healthcare System while increasing the practice of rehabilitation is to devise therapies and technologies that can be administered at home by caregivers and telemonitored by rehabilitation staff. The aim of this proposal is to promote early intervention in the first year of life and to reinforce therapy by CareToy": a portable low cost smart system telemonitored thus augmenting the clinical effectiveness of the therapy while reducing the cost. The smart system is based on a common baby gym, composed of different modules: a) an instrumented baby gym with mechatronic hanging toys, so that the infants' actions on the gym can be measured and stimulated, b) a vision module, for measuring and promoting infants' attention and gaze movements and c) a sensorized mat for measuring and promoting postural control. Each module will also incorporate built-in signal processor, memory and wireless communication. A fourth telerehabilitation module completes the system that allows the system to remotely communicate with the rehabilitation staff for monitoring and assessing the rehabilitation techniques. CareToy and the effectiveness of home rehabilitation based on this system will be validated by clinical trials on 100 preterm infants with different brain lesions. The result of this project could have a large impact. CareToy m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Revealing genes that mediate the CIN-induced interferon-inflammatory response using a Genome-wide CRISPR screen coupled to a Suicide Gene Switch.' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Chromosomal instability (CIN) and the resulting aneuploidies can fuel the dramatic karyotype changes characteristic of tumorigenesis, helping tumors to alter the expression of immune checkpoints and evolving phenotypes related to immune evasion or stimulation.  Anti-tumor immunity appears to be dependent on the type and origin of the tumor, while immune evasion has become an obstacle to designing effective anticancer therapeutics. Understanding when CIN promotes or suppress anti-tumor immunity is therefore needed. However, the mechanism and initiators by which this adjustment occurs and the role that aneuploidy, CIN or specific karyotypes have in this transition are still in the dark. In order to understand how CIN drives tumor evolution, we need to know how CIN guide cells into different immunogenic responses. Identifying the genes that adjust the role of CIN and aneuploidy in immune evasion can therefore help us unravel the origins of malignant growth and in the future develop more appropriate therapeutic approaches. My project plan is set to find the genes that trigger and connect chromosome missegregation to the interferon-inflammatory response in cells suffering from CIN using an unbiased genome-wide CRISPR KO screen coupled to a suicide gene switch in human fibroblasts. The use of a suicide gene switch, normally used for cell-based therapy, allows separation of cells that have lost the inflammatory pathway while the screen, along with a next generation sequencing, will find the genes related to that loss.  This screen will serve as a base to understand what underlies cancer immune evasion in chromosomally unstable cells.


**Keywords:** CIN, inflammatory response, cancer, CRISPR, suicide genes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Roll-2-Roll and Photolithography post-processed with LAser digital technology for FLEXible photovoltaics and wearable displays' (RoLA-FLEX).

assistant: **Innovation**

RoLA–FLEX is an industry driven project which provides innovative solutions to the existing OLAE challenges associated with performance and lifetime, through:(a) the fabrication and upscaling of organic semiconductors with high charge mobilities (up to 10 cm2/Vs) and high power conversion efficiencies (16% in OPV cell and 12% in OPV module); (b) the development of metal oxides for charge carrier selective contacts and metal nanoinks for highly conductive micropatterns with increased environmental stability; (c) the seamless incorporation of high speed laser digital processing in Roll-2-Roll OPV module fabrication and photolithography based OTFT manufacturing and (d) the demonstration of two TRL5+ OLAE prototypes enabled by the developed materials and innovative processes: 1. A smart energy platform for IoT devices powered by ITO-free and flexible OPVs operating at low indoor light conditions. 2. A new generation of bezel-less and fully bendable smart watches integrating FHD, ultra-bright OLCD/OTFT displays. RoLA-FLEX will advance all the aforementioned technologies to at least TRL5 within its timeframe. RoLA-FLEX will create an opportunity for a yearly increase in revenues of almost €400 M only 6 years after its end, accompanied by hundreds of new jobs. A timely investment in the early days of these new markets can ensure significant market share for the SMEs and Industries involved and greatly boost EU’s competitiveness globally.


**Keywords:** OLAE, Laser processing, R-2-R, photolithography, organic photovoltaics, flexible displays, wearable electronics, high mobility organic semiconductors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Art Thou Researching?'.

assistant: **Innovation**

The aim of this project is to confront two apparently opposing scenarios - that the researcher is a lab-coat donning reclusive nerd living in an ivory tower, and that the artist lives a life of bohemian rules and laissez-faire attitude - with each other and against reality. Researcher's Night offers a unique opportunity to get this message across, not only to young people, but also to their parents, leaders, educators and prospective employers. This will be done through a series of activities which will be designed to be fun, targeted at as wide an audience as possible and highly visible. The theme ART Though RESEARCHING? has been chosen to also help increase the attractiveness of investment in R&D by improving the perception of the general public of Researchers though, amongst other things, the use of Art.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Rationalised economic appraisal of cultural heritage'.

assistant: **Objectives**

The management and costing of the care of cultural heritage is a multidiscipinary activity involving both technical and economic information. In order to provide managers with the right information a multi-disciplinary package is required which combines both the economic and technical data in an accessible format. Modern Information Technology (IT) techniques enable seamless blending of diverse types of information, such as technical, economic and cultural data, and immense flexibility regarding user interaction. Such techniques are ideally suited to draw together International expertise on heritage matters, spatial and temporal modelling of air pollution, and environmental policy and standards, into a integrated package with an accessible user-friendly interface. This would enable those in control of monuments to readily assess the economics of intervention at local and national level drawing on current 'best practice' defined in the integrated interactive package. The proposal will develop a basis for an integrated IT economic management tool focusing on providing a cost benefit analysis of remediation to cultural heritage buildings. The project aim is to produce a prototype package incorporating data from the partner countries with case studies on the use of the package for prominent buildings in a number of European countries. The project will evaluate the options for designing software and providing ancillary information across a number of different IT platforms (e.g. PC, Internet, mainframe) with the objective of determining whether it is possible to enable practitioners, surveyors, architects, owners and regional civic bodies to arrive at an estimate of the cost benefit associated with the management of buildings within their care using such a system. The work is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Identification and functional dissection of key genetic events in early chronic lymphocytic leukemia' (2007-2013).

assistant: **Concept**

Clonal evolution represents a central feature of tumor progression and relapse. Chronic lymphocytic leukemia (CLL) is a valuable model to study this process due to a high prevalence, initially slow progression and the easy availability of samples. Recent large-scale sequencing studies have identified putative driver genetic events of CLL, uncovered the vast inter-personal and intratumoral genetic heterogeneity in CLL and have linked the presence of aggressive subclonal mutations with clonal evolution and poorer outcome. The patterns of different aberrations within the same sample suggest a temporal hierarchy in acquisition of genetic events, and a stepwise transformation of disease from diagnosis to later more aggressive stages. To directly test these ideas, I will systematically examine the clonal dynamics of a cohort of 17 CLL patients that were recurrently sampled over years from diagnosis until the time of first treatment. Through this longitudinal study, I will seek to identify the early events in this initially indolent malignancy leading to disease progression and how the order of genomic aberrations dictates tumor fate and biology (Aim 1). To directly test the functional impact of these early genetic events on B cell biology, we will utilize novel TALEN genome-engineering technology to generate cell lines harboring key mutation events (Aim 2). The generation of these isogenic cell lines will enable me to determine the relative fitness of putative CLL drivers in vitro and to study the effect of established and novel cytotoxic and targeted drugs on the dynamics amongst CLL subpopulations (Aim 3).Answering these questions will facilitate translation of novel genetic insights towards the development of individualized diagnostic and therapeutic management of CLL.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a novel medical oxygen concentrator enhanced with spirometry and telemetry functionality.' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Oxygen therapy is prescribed to patients with chronic obstructive pulmonary diseases (COPD), one of the most rapid increasing causes of death. The oxygen used can be liquefied or pressurized but is more often generated in place from ambient air with a concentrator unit. Current concentrators have numerous disadvantages, which result in a serious restriction of mobility and poor compliance to therapy. The development of a more comfortable and cost-effective oxygen concentrator method based on novel membrane technology is proposed. The concentrator will be enhanced with pyrometer, sensory, telemetry and medicine-dosing functionality creating possibilities for a whole new concept of oxygen therapy involving dynamic on demand adjusted therapy and telemedicine and monitoring possibilities for the physician. The enhanced oxygen therapy possibilities can improve quality of life of COPD patients by keeping them longer fit and independent.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'A European Infrastructure of Ligand Binding Molecules Against the Human Proteome'.

assistant: **Innovation**

The objective of this proposal is to coordinate the establishment of a European resource infrastructure of binding molecules directed against the entire human proteome. A major objective of the post-genome era is to detect, quantify and characterise all relevant human proteins in tissues and fluids in health and disease. This effort requires a comprehensive, characterised and standardised collection of specific ligand-binding reagents, including antibodies; the most widely used such molecules, as well as novel protein scaffolds and nucleic acid aptamers.Currently there is no pan-European platform to coordinate systematic development, resource management and quality control for these important reagents. This CA will coordinate 25 European partners and two in the USA, several of which operate infrastructures or large-scale projects in aspects including cDNA collections, protein production, polyclonal and monoclonal antibodies. They provide a critical mass of leading expertise in binder technology, protein expression, binder applications and bioinformatics. Many have tight links to relevant SMEs, as founders or advisors.The CA will plan the organisation of the resource, by integrating existing infrastructures, reviewing technologies and high throughput production methods, standardising binder-based tools and applications, assembling bioinformatics and establishing a database schema for a central binders repository. The proteome binders' resource is predicted to have huge benefits for basic and applied research, impacting on healthcare, diagnostics, target discovery for drug intervention and therapeutics.It will thus be of great advantage to the research and biotechnology communities. In general terms, Europe is already well advanced in the technologies required and excelle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The compilation of field measurements on buried pipes and their comparison with estimated design results' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Experts involved in the work of CEN/TC lS4-165/JWG 1 several times highlighted the need of measured data taken from installed pipes to be compared with results derived from the future approach and existing design methods. Measured data collated up to nov were only usable for qualitative conclusions. A need for more detailed measurements specially on pipes made from glass-reinforced thermosetting resins on which product specifications currently are being developed under the CPD, PPD and PED has been detected. Very limited work has been done to date by CEN/TC 155/WG 14/TG 3 being responsible for glass-reinforced plastics pipes to compare measured data with estimates. This group is working on a design approach for this type of pipe to support CEN/TC 164-165/JWG 1 drafting the future European design method which will result in an increase in the safety of the operating system and a consequential reduction in the probability of the occurrence of leakage resulting in environmental pollution. CEN/TC 155/WG 14 has highlighted the need for more detailed work to be done in this proposed research project. Seven tasks are proposed to be worked in order to achieve an increase of reliability of the design methods available or a new approach to be developed. Existing field data on buried GRP pipes together with information about soil materials, trench and loading conditions as well as data from past soil box testE need to be re-collated and analyzed (Task 1). A range of different classes of GRP pipes covering various existing manufacturing processes needs being produced and examined to assess their properties and the related variances (Task 2). An experimental test field covering a range of variations relative to proportions and environmental conditions such as water table, etc. will