RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dissecting the Mechanism of Nucleosome Retention in Mouse Spermatozoa' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Studies in mice and men suggest that changes in environmental conditions such as nutrition, exposure to environmental pollutants or parental care during early postnatal life can affect the development, physiology and fitness of offspring. The epigenetic mechanisms underlying the transmission of such traits over one or multiple generations are largely unknown but DNA methylation, RNA and nucleosomes have been proposed as mediators of such inheritance. At the end of male germ cell development chromatin is extensively remodeled, resulting in a highly compact nuclear architecture in spermatozoa that is compatible with fertilization. During this process, most but not all nucleosomes are removed and replaced by protamines. The host laboratory recently demonstrated retained nucleosomes localize at CpG islands of the genome that are present within regulatory regions of genes, suggesting that these regions may confer epigenetic inheritance between generations. Preliminary data implicate different histone H3 variants and modifications in the nucleosome eviction and retention process.Here I aim at dissecting the mechanism of nucleosome retention in mouse sperm. Using a quantitative biochemical approach, I will test the possibility that nucleosome retention at CpG islands is an indirect consequence of high intrinsic affinities of protamines for GC-poor DNA. I will determine the composition of evicted versus retained nucleosomes in terms of histone variants and post-translational modifications, by performing immunoprecipitation coupled to mass spectrometry. Importantly, I will investigate whether nucleosome retention is controlled by a “retention factor” using a mass spectrometry approach combined with cellular and genetic assays. The proposed research will provide mechanistic insig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Inspiring CitizeNS Participation for Enhanced Community PoliCing AcTions'.

assistant: **Objectives**

INSPEC2T projects’ scope is to develop a sustainable framework for Community Policing that effectively addresses and promotes seamless collaboration between the police and the community. INSPEC2T approach bases its conceptual foundations on EU crime prevention and Member States specific Internal Security Policies, validated research results and best practices from cooperation between police and local, regional and national communities. This is perceived as an origin to apprehend special characteristics, particularities and determinants for trust between all stakeholders. INSPEC2T is focusing on a user-centric design and development approach, and has already mobilized and engaged a critical user group mass, in EU and abroad. With special emphasis on social media, it consolidates and modernizes bidirectional communication of stakeholders, using multi-level anonymity flags and having a clear understanding of acceptability issues. Driven from accommodated transnational and multicultural best practices, it adheres to an approach where social, cultural, legal and ethical dimensions are embedded into core user centric design specifications and implementation procedures. INSPEC2T will be demonstrated and validated in 5 EU cities by a wide range of relevant stakeholders. INSPEC2T engagement and active participation is stimulated through fully dynamic, interactive and immersive training Serious Game applications that empower players to familiarize themselves with the system, gain an intuitive understanding of its functionalities and motivate their engagement in Community Policing activities.  Special focus will be given to Community Policing awareness raising activities for both police and citizens. The above activities and associated results, will provide a solid foundation for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Enhanced Code Galileo Receiver for land management in Brazil' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Taking benefit of the new Galileo ranging signals, the ENCORE project aims to develop a land management application to cover the following needs of the Brazilian market:-Geo-referencing: due to 10267/2001 Federal Law, all the 5 billions properties in Brazil must be linked to the Geocentric Reference System for the Americas (SIRGAS), whose objective is the standardisation of South America geodetic systems. All these properties are subject to surveying.-Urban/rural cadastre: Brazil includes 500 millions of hectares for farming, but one third of them are not properly identified, being occupied informally. This is an important drawback to allow and efficient use of the farmland, an optimised urban planning, and to perform tax collection.The proposed land management application will cover these Brazil’s needs in terms of geo-referencing and cadastre planning, using an Enhanced Galileo Code Receiver as baseline. As an example, it will solve the problem of land regularization at the Legal Amazon area of Brazil.In current GNSS terminals, there is a gap in terms of performances, receiver complexity and price between mass-market and professional devices. Land management applications require precision and accuracy levels from a few to several decimetres that are under-met with current pseudorange-based mass-market receiver and over-met with professional terminals based on phase observables. This situation leads either in a waste of resources (equipment, time, over-qualified staff), or in lack of accuracy. In this project, it is proposed to fill this gap using the new possibilities of the Galileo ranging signals, in particular E5 AltBOC and L1 MBOC. The Enhanced Galileo Code receiver will use them to generate the best possible pseudorange measurements, which are the inputs of the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Remote technical assistance for field service operators' (RemoTech).

assistant: **Innovation**

In current competitive manufacturing market, continuous operation of machineries becoming the vital point and is considered to be the key performance indicator of productivity. Machine downtime costs time and money for enterprises. EU business community losses almost 1 million hours per year due to machine downtime. In general, it takes ca. 54 hours per year for a company to repair machines and it losses ca. €0.35 million per year for on premise machine-repair. Thus it is very important to have an integrated solution to reduce this expensive inconvenience as quickly as possible. We have developed an innovative software based solution for providing remote technical assistance to field service operators by support department experts. Currently, RemoteEye is the only telepresence solution in the market available adopted for wearable technologies e.g. smart watch and smart glass. Additionally, our easy, fast and cost effective system can also be used by smart phones, tablets (iOS and Android) and desktop computers. Our aim is to become the pioneer in remote telepresence solution with main attention on wearable and/or augmented reality where we can outperform our competitors. Our system solves the issue and saves time and money by reducing technicians’ travel time and expenses. The cost for the client is only a small fraction compared to the money saved through repairing their machinery in a fast and efficient process. With our software, we initially estimate technical assistance savings of 62%. This project will study the detailed nature and extent of the field service market, the interrelation between various market factors, new technology and technological trends that may influence the market. Based on the results the solution will be further enhanced, detailed and scaled
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advancing NANOmedicines to rewire tumoral MYeloid cells for next-generation cancer immunotherapies' (My-NANO).

assistant: **Innovation**

Persistent inflammation during tumorigenesis drives myelopoiesis. Consequently, monocytes and granulocytes/neutrophils infiltrate the tumor microenvironment (TME) and differentiate into tumor-associated macrophages or myeloid-derived suppressor cells, creating an immune-suppressive microenvironment that hampers cytotoxic T cell function and limits immune checkpoint inhibitor (ICI) efficacy. ‘Reprogramming’ myeloid cells to adopt pro-inflammatory phenotypes is promising to restore immune function and enhance ICI responses. Lipid nanoparticles (LNPs) have emerged as a delivery platform for nucleic acids, as demonstrated by the mRNA-LNP COVID vaccines. Pioneering studies revealed that myeloid cells are robustly recruited to the vaccine injection site where they internalize mRNA-LNPs, leading to mRNA expression in monocytes. While nanoparticle (NP) transport into inflamed tissues and tumors has been attributed to ‘enhanced permeation/retention’ of the NPs, my recent findings, in an inflamed arthritis model, highlight a critical role of circulating myeloid cells in the active transport of intravenously injected LNPs. Therefore, I hypothesize that mRNA-LNPs can transfect tumor-infiltrating myeloid cells reversing immune-suppression. My-NANO will study interactions between myeloid cells and lipid-based NPs through the following objectives: (1) elucidating the role of myeloid cells in the transport of lipid-based NPs to tumors (WP1), (2) investigating how mRNA-LNPs influence innate immune responses/phenotype switches in myeloid cells (WP2) and (3) optimizing mRNA-LNP design for efficient/selective mRNA expression in myeloid cells (WP3). Based on this knowledge My-NANO will design mRNA-LNPs to restore the phagocytic function of myeloid cells by knocking out SIRP-1α or by generat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Chemical Approach to Lead-free Nanosolders' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Physical, electronic and thermodynamic properties of small particles (nano-particles) differ significantly from those of the bulk materials, and the depression of the melting temperature below the melting point of the bulk has been known for a long time. This dependence of the melting temperature on the particle size is not restricted to any particular material and may therefore also be exploited to lower the melting temperatures of lead-free solders. At the same time, the high-temperature solders currently in use (melting temperatures 250-400°C) contain high amounts of lead and are exempt from the European RoHS directive due to reliability reasons. In the search for lead-free substitutes, Sn-Sb and Sn-Sb-M alloys have been identified as possible candidates. With the envisaged reduction of the grain size into the nanometer range and a corresponding lowering of the melting temperature, considerable energy savings would become possible in the first soldering step without sacrificing the stability of the obtained solder junctions against re-melting in the further assembling procedure. Therefore it is proposed to prepare micro- and nanosized particles of lead-free high-temperature solder materials, based on Sn-Sb-M (M=Ag, Cu, Ni) from suitable chemical precursors. These precursors will be prepared by precipitation reactions, followed by thermal decomposition and, if necessary, by adequate reduction reactions, and the reaction conditions will be optimized. The particles will be characterized by chemical analysis, SEM and TEM, and by thermo-analytical methods, and the corresponding properties will be compared with those of bulk materials. At the same time, additional experiments in the bulk systems Sn-Sb-Ag and Sn-Sb-Cu will be performed to complete the available literature i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Management of the environment and resources using integrated techniques (MERIT)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Integrated management is the key to the sustainable development of Europe^ TMs water resources. But this approach means that decisions must be considered not only in environmental terms, but also in the light of their economic, social, and political impacts. The problem is to find a practical way to link these different factors together. MERIT will develop an integrated, water resource management methodology that meets this challenge. The methodology will be based on Bayesian belief networks, a type of model-based decision support system already used routinely in the fields of medicine and artificial intelligence. To track the success of management decisions a set of quantifiable water resource indicators will be incorporated into the networks. We will demonstrate the technique in 4 catchments where stakeholder groups will contribute to the design and content of each network. The result will be a computer-based, generic, management tool based.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Identification of scientific contents in the daily life'.

assistant: **Innovation**

acib is planning an open event for the young general public in the frame of the European Researchers’ Night in Austria. Under the roof LifeisScience the visitors gain insights into the every-day work of researchers in the manifold fields of biotechnology and related disciplines as well as its impact to our daily life. LifeisScience offers to discover scientific contents along three dedicated story lines  by visiting laboratories, contributing in experiments, interrogating scientists about buzzling questions, exchanging ideas in debates, participating in open innovation science, watching demonstrations and learning more on recent scientific discoveries. The story lines are food technology, waste management & renewable resources and health. The different activities intend to allow visitors to identify connections between research and our daily life. The principle of collecting stamps for each activity and receiving a gift for absolved story lines aims to drive visitor’s motivation and, thereby, some may discover their passion for science and their preference for a research career.


**Keywords:** life sciences, science communication, biotechnology, MINT disciplines, citizen science, open innovation, game-based learning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'BIoGeochemistry in a high CO2 World (BIGCOW): lessons from the Ocean Anoxic Events' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Model predictions are regularly made about the state of marine ecosystems and carbon cycle in a future high CO2 world. But while increased ocean stratification means lower future biological export production in some models, in others, higher temperatures inducing faster rates of biological activity drive completely the opposite response. Rates of nitrogen fixation may increase in a warmer ocean and support higher production, but at the same time, loss rates of nitrate will increase as oxygen minimum zones expand and intensify. The cycling of iron also plays a critical role in controlling marine productivity and may limit nitrogen fixation. Yet, while iron bio-availability will be affected by changes in temperature, acidity, and oxygenation, no current model accounts for how iron solubility will respond to future ocean geochemical environmental changes. How can we increase confidence in predicting the intertwined response of nutrient and carbon cycles in a high CO2 world? The geological record contains case studies into the range of possible Earth system behaviours, states, and strengths of feedbacks. Of particularly interest here are the Ocean Anoxic Events of the Mesozoic, which were associated with profound global-scale perturbations of climate and marine biogeochemical cycles, high plankton turnover rates and biological extinction, and the burial of economically important quantities of organic carbon in black shales. They have relevance to future marine biological consequences of warming and acidification, and the spread oxygen minimum zones. Here we propose the first model of marine iron cycle applicable to a high CO2 world, the first analysis of the dynamical interaction of all three nutrient cycles (P, N, Fe), CO2, and climate associated with the onset of Ocean An
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Climate change, phenology and reproduction: Mediterranean sponges as models' under Sixth Framework.

assistant: **Concept**

Potential effects of global change act at different organization levels from physiological to community and can affect the biodiversity and ecosystem functioning. PHENOMED will be implemented in NW Mediterranean coastal ecosystems, because they harbour a high biodiversity which suffered dramatic effects of the global change.   This programme proposes an approach which aims at understanding the recent and forthcoming effects of the warming at the life/reproductive cycle level. Although the resilience of a population severely affected depends on its reproduction and dispersal abilities, almost nothing has been done for assessing the potential effects on of thermal anomalies on the benthic organisms at reproductive level. PHENOMED will thus contribute to a better understanding of the impact of strong disturbances on the phenology in order to provide management and conservation advices.   For this purpose, we will comparatively investigate reproductive cycles and strategy of temperature sensitive and tolerant species living in different ecological conditions. Our models - Porifera is one of the most abundant groups of metazoans within hard substratum communities, which provide services to human societies and have been severely affected by high temperature events during the last decades.   The detailed objectives are:  (i) Characterizing the gametogenesis, embryogenesis, larval ultrastructure, metamorphosis, and recruitment of target sponge species.  (ii) Acquiring baselines on their life cycle and reproductive effort.  (iii) Studying the modification of the reproductive cycles and strategies in natural and experimental conditions.  (iv) Assessing experimentally the warming effect at the cellular level.   PHENOMED will thus combine in vitro and in situ approaches that will p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Three step fermentation of solid state biowaste for biogas production and sanitation (3A-BIOGAS)' to be submitted under Fifth Framework.

assistant: **Abstract**

Objectives and problems to be solved:In Europe renewable energy (RE) in solid state biowaste is an area with considerable unused potential. Biogas produced out of this biowaste can be applied for fuelling gas turbines in CHP plants or fuel cells. Available kinds of such dry biowaste include municipal solid waste (MSW), separately collected biowaste, waste from the food industry, garden and horticultural waste, material harvested from areas left fallow, etc.The most used method for treating these wastes is conventional composting: Compost is produced by aerobic degradation with loss of heat to the atmosphere. Anaerobic digestion (AD) of liquid materials below 15% dry matter (DM) is widely used and technologies for this application are well established. Treatment of solid state materials in conventional biogas plants has several disadvantages associated with the large amount of process water required: there is a high energy demand for heating and pumping the process water and sometimes for pressing the digested material. At the end of the process wastewater must be treated.3A-BIOGAS is a combination of aerobic and anaerobic processing in three steps: 1. aerobic, 2. anaerobic, 3. aerobic. The process generates biogas from solid state biomass (30-70% DM) and therefore uses the energy capacity of the biowaste. The innovative percolation water management avoids further wastewater. Sanitation will take place within the 1st step, further sanitation, deodorisation and final rotting in the 3rd step. The produced compost is predicted to meet the maturation and hygienic requirements of EU Working Document an biowaste treatment /1.1/. It can be used for fertilising and soil improvement.Biogas production as liquid process is mainly addressing the agricultural waste treatment industry