RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The development of 99m tc-based imaging agents for studying aspects of the dopamine receptor system in the human brain' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content The overall objective of this project is to develop a Tc-99m based radiopharmaceutical agent for selectively imaging particular dopamine receptor in the brain. The abnormal behaviour of this biological system is associated with a number of important me conditions and a means of measuring the in vivo impact of drugs on this system be great value in optimising the dose needed for effective treatment.The development of the imaging agent will be achieved by incorporating a chelat system capable of binding the Tc-99m radioisotope into a molecule known to bind the D2 receptor. The design of the overall molecule must be such that its metal must be able to cross the blood brain barrier, and the method of attachment of chelate system to the biological active portion of the molecule must be such that does not destroy its ability to bind to the receptor. Training content (objective, benefit and expected impact) The proposed project will involve a wide range of chemistry and will provide go training in the design, synthesis and purification of polyfonctional compounds. Experience will be gained in the synthesis of polydentate chelate, use of coupling techniques and protecting groups. In addition, the need to liaise closely with International plc and the Nuclear Medicine team at St. Bartholomew's Hospital in London in connection with labelling and biological testing will provide som ins into the way in which new radio pharmaceuticals are conceived and developed in and the important role that nuclear medicine now plays in diagnostic medicine. Links with industry / industrial relevance (22) The radio pharmaceutical company Amersham International plc have agreed to participant in the radio-labelling and evaluation of the compounds produced during the cou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Receptor-like Kinase Signalling in Arabidopsis thaliana Root Development' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The past decade researchers have mainly focused on the analyses of phytohormone gradients and mobile transcription factors to explain patterning. In Arabidopsis, model processes like primary and lateral root development are well understood on the level of transcriptional changes and hormonal control, but very little attention has been given to an alternative way of cell-cell communication using ligand-receptor-like kinase systems (De Smet et al., 2009, Nat Cell Biol, in press). Lately a number of receptor-like kinases and potential ligands have been described in root development (De Smet et al., 2008, Science 322:494-497; Müller et al., 2008, Plant Cell 20:934-946; Stahl et al., 2009, Curr Biol 19:909-14), making it a perfect time to start investigating how these receptor-like kinases and their respective ligands control the different developmental processes and what their targets are. More and more tools become available to study difficult membrane proteins on the level of 3D structure, phosphoproteomics, and in silico ligand identification. In brief, I will use different and interdisciplinary strategies, based on state of the art transcriptomics, proteomics, interactomics, associomics and more in depth analysis on the single gene/protein/ligand level to describe ligand-receptor-mediated cell-cell communication during root development, and, more specifically, to identify key components in ACR4-dependent signalling. The aspects this project plans to address would contribute extensively to the knowledge of membrane associated receptors-like kinases in general, have rarely been covered focusing on one receptor-like kinase, and will allow elucidating the mechanisms and structural aspects behind this crucial ACF4-dependent signaling pathway, such as: (1) identification of d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Old Pious Vernacular Successes: best-selling vernacular religious literature in medieval Europe (1230-1450)'.

assistant: **Concept**

The OPVS project challenges previous studies by resorting to the medieval readers  perspective in order to rank medieval Europe s  bestselling  vernacular religious texts: we shall focus on successful texts with voluminous manuscript traditions, taking into account the most popular ones, extant in over 60 copies. All were written (or translated) in French, English or German: texts composed in other vernacular languages were not so widely disseminated.These manuscripts will bear testimony as to how, when and where they were produced. Because they have traces of their owners and have been annotated by medieval readers, they can also yield new data on medieval pious practices and religious reading.Previous studies have generally eschewed this documentary evidence, except in the case of deluxe copies. This neglect is due both to a greater interest for Latin treatises with lofty ambitions, and to the impossible challenge, for a single researcher, of dealing with multiple manuscripts, kept in libraries worldwide   hence the need for new investigating methods and teamwork.Our project s novel perspective consists in studying these manuscripts both individually and comparatively, combining a traditional erudite approach and new serial methods (quantitative codicology). Relying on an innovative database, our aim is a) to develop a sophisticated typology of medieval religious manuscripts in vernacular languages, b) to determine when, where and in which milieus the selected texts were copied and circulated, giving new insights into all the agents involved in the European book trade of religious literature in vernacular languages   especially workshops and book owners, and finally c) to produce comparative studies of medieval literacy and readership in France, England and Germany.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Liposomes as nanoreactors for the bottom-up assembly of supramolecular structures in confined space' (LipoNanoReactors), addressing dissemination and exploitation.

assistant: **Impact**

Nanoreactors are attractive systems for emerging technologies because they allow the manipulation of matter on a molecular scale to fabricate macroscale products. Consequently, nanoreactors have been used to carry out molecular synthesis and catalysis, where such processes are controlled and stimulated by confined space. However, the current nanoreactors suffer from a lack in the flow-control of substrate that can access their interior and they have not been used to build large supramolecular structures. To overcomes these disadvantages and improve the application of nanoreactors, in this project we propose a novel design of a nanoreactor based on the combination of liposomes and molecular transporters (LipoNanoReactors). We envisage that by a controlled transport of ions (metal cations or organic anions) through phospholipid membranes, we will be able to build supramolecular structures inside liposomes, where the final structure could be modulated by the rate of ion flow and confinement effects. As a result, this strategy will allow us to control the physical and chemical properties of such structures on a nanometric scale. Further than achieving supramolecular assembly inside liposomes, the present proposal looks to facing challenges as supramolecular isomerism, crystalline phase purity, and particle size control. Accordingly, this project opens new horizons in the field of crystal engineering, solid-state chemistry, and material sciences.


**Keywords:** Liposomes, Transmembrane ion transport
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Characterisation and tailoring of Attosecond pulse trains for applications'.

assistant: **Objectives**

It was realised shortly after the discovery of high-order harmonics, that the broad frequency range of plateau harmonics support pulses of sub-femtosecond duration. After the experimental demonstration of the presence of such pulses, a rapid progress of the field has been witnessed.The main objective of this proposal is to fully characterise these extreme ultraviolet pulses and to use the knowledge gained via the characterisation method to produce tailor-made laser pulses of attosecond (10-18 s) duration, u sing high-order harmonic generation. Many aspects of the generation, characterisation and implementation of attosecond pulses still have to be investigated, before attosecond pulses can become a routine tool that can be as widely used as present day femtosecond lasers.The specific tasks are as follows:- Complete characterisation of high-order harmonic generation and the produced attosecond pulse train.- Search for the long quantum path and its influence on the attosecond pulse train.- Tailor the properties of the pulses in the train, as well as their relative timing for applications.- Isolation of a single pulse of the train using a generating pulse with time-varying ellipticity.Each task shall be achieved via a combination of experimental (the harmonic generation setup, available at the host institute, is unique in the sense that it allows for independent manipulation of pump and probe beams, therefore it is ideal for carrying out the proposed project) and theoretical methods (modelling experimental conditions).As a result of the mobility period the applicant will have acquired most of the necessary skills to carry out an outstanding career by having been taught many scientific, managerial, social and educational skills, making contacts with important scientific gro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Study of mechanisms involved in ozone loss over Europe based on satellite observations and numerical models' (1994-1998).

assistant: **Concept**

Research objectives and content: The project will involve the completion of the firs ever self-consistent data set. This will allow a more accurate investigation on the whole issue of ozone depletion, and provide mechanistic insights into the chemistry and dynamics of the atmosphere at an unprecedented level of detail. In particular we will use the technique of data assimilation to study in detail the ozone loss mechanisms in operation over Europe based on a self-consistent analyses of stratospheric constituents obtained from measurements made by the UARS and GOME satellites. Something which has never been done before. The work will be done will improve the technique of data assimilation and apply it in new ways to remotely-sensed observations of the atmosphere. It will use data assimilation to make efficient and effective use of remotely-sensed data in support of European and international and international programmes of Earth Observation. Training content (objective, benefit and expected impact) The project will provide an inter-disciplinary training in the various branches of atmospheric science, embracing physics, chemistry, mathematical methods, meteorology, and computer science. It will extend my understanding of computer simulation, data analysis, and visualisation. It will also improve my language skill. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Kinship, Alliance and Urban Space: the Genoese 'alberghi' in the Late Middle Ages (c. 1150 - c. 1450)' (GenALMA).

assistant: **Innovation**

GenALMA aims to offer novel perspectives and invaluable new data on kinship and the development of urban space by examining late medieval Genoa, one of the most socially vibrant cities during the foundational phase of contemporary Europe. It will investigate: 1) why and how aristocratic families chose to unite in a peculiar form of association which had long-lasting repercussions across the city’s social spectrum, eventually involving families and individuals of lesser social standing; 2) the impact of the construction of such solidarities and alliances, and the patrimonial strategies these entailed, on the reconfiguration of the city’s residential and architectural landscape. By tackling these two main questions, GenALMA will address issues related to the development of kinship structures and gender roles, the evolution of patrimonial rights, the networks of socialisation, and the changes in the urban fabric. Employing an innovative interdisciplinary methodology, the project will involve the management (through multiple databases) of large data sets collected from still unexplored and exceptional historical sources (notarial records of Genoa) which will be used to reconstruct kinship ties and to map out residential patterns thanks to cutting edge technology available at the host institution. The digital maps will represent an unprecedented attempt at charting the evolution of the urban fabric over the span of three centuries. The project will be conducted at the CNRS – Centre Roland Mousnier where the candidate will benefit from high level interdisciplinary training offered by the host institution, which will improve her skills in analysing historical data, and from the presence of several specialists with whom to discuss methodological and historiographical approaches
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Going Local in the Perso-Islamic Lands: Afghan Geniza, Islamisation and Language in the pre-Mongol Islamic East'.

assistant: **Objectives**

Multilingual and culturally diverse adaptations – not doctrinal uniformity or Arabisation – have allowed Islam to dominate the eastern Islamic lands in what is today Afghanistan, Iran and Central Asia. While Islamic fundamentalism exemplified by the bombing of the Bamiyan Buddhas has dominated the discourse on Islamisation in the region, it remains unclear when and how such forms of adaptations arose. Previous research has argued that caliphal and sultanic authority underlie local realities in the pre-Mongol Islamic East. But the latter show central control, suggesting the underlying mechanisms at local level might be different. A better model for the spread of Islam in the East and its countryside might be local innovation and adaptation. In 2013 and 2017 when the newly discovered Afghan Geniza was made publicly available for the first time, it became possible to test this hypothesis for the pre-Mongol Islamic East.  Using both a top-down and bottom-up testing approach, GO.LOCAL will test whether Islam is a manifestation of cumulative culture – currently the implied hypothesis in the field – or whether it is best accounted for with the local anchoring model. That is GO.LOCAL will evaluate whether Islam and Islamisation are more similar to local innovations in authority and language than developments at imperial capitals and other central hubs. The outcomes and conclusions of GO.LOCAL will therefore inform several fields at once (e.g. history, sociolinguistics, anthropology, archaeology and theology). This proposal is the first to test the local anchoring account developed by classicists in the Islamic East. If its predictions are confirmed, then multilingualism and cultural diversity will have emerged as far more important as factors in Islamisation than previously ass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'A holistic frameWork with Anticounterfeit and inTelligence-based technologieS that will assist food chain stakehOlders in rapidly identifying and preveNting the spread of fraudulent practices.'.

assistant: **Innovation**

WATSON provides a methodological framework combined with a set of tools and systems that can detect and prevent fraudulent activities throughout the whole food chain thus accelerating the deployment of transparency solutions in the EU food systems. The proposed framework will improve sustainability of food chains by increasing food safety and reducing food fraud through systemic innovations that a) increase transparency in food supply chains through improved track-and-trace mechanisms containing accurate, time-relevant and untampered information for the food product throughout its whole journey, b) equip authorities and policy makers with data, knowledge and insights in order to have the complete situational awareness of the food chain and c) raise the consumer awareness on food safety and value, leading to the adoption of healthier lifestyles and the development of sustainable food ecosystems. WATSON implements an intelligence-based risk calculation approach to address the phenomenon of food fraud in a holistic way. The project includes three distinct pillars, namely, a) the identification of data gaps in the food chain, b) the provision of methods, processes and tools to detect and counter food fraud and c) the effective cross border collaboration of public authorities through accurate and trustworthy information sharing. WATSON will rely upon emerging technologies (AI, IoT, DLT, etc.) enabling transparency within supply chains through the development of a rigorous, traceability regime, and novel tools for rapid, non-invasive, on-the-spot analysis of food products. The results will be demonstrated in 6 use cases: a) prevention of counterfeit alcoholic beverages, b) preservation of the authenticity of PGI honey, c) on-site authenticity check and traceability of olive o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Gas-phase two-dimensional rovibrational infrared spectroscopy of volatile organic compounds' under Horizon 2020.

assistant: **Concept**

The goal of the fellowship is to build an ultrasensitive two-dimensional infrared spectrometer and apply it to detection of complex mixtures of trace amounts of volatile organic compounds (VOCs).  Third-order spectroscopies using ultrashort pulses, such as 2D IR spectroscopy, are powerful tools for studying both structure and dynamics. They probe the evolution of state-to-state coherences between quantum states and evolution of state populations on femtosecond to nanosecond timescales, in between excitation by ultrashort optical pulses. In terms of molecular properties, 2D IR spectroscopy probes correlations between molecular bonds, which strongly depend on the structure of the molecule as a whole. Compared to linear spectroscopy, which is more bond-specific, 2D IR spectroscopy provides much greater selectivity. Compared to mass spectrometry methods, it is applicable to both small inorganic molecules and to VOCs and easily lends itself to quantitative analysis. 2D IR spectroscopy has not been used for trace-gas analysis up to now because of insufficient sensitivity. This project overcomes this problem by building first of its kind cavity-enhanced 2D IR spectrometer, with up to four orders of magnitude better sensitivity than the previous state of the art, and applying it to vibrational spectroscopy of VOCs. The potential for exploitation of the project outcomes includes breath analysis diagnostics, detection of explosives, narcotics and other trace-gas analysis problems. There are also many potential applications of the outcomes in basic science, in the field of ultrafast dynamics of optically dilute samples (e.g. cold molecular jets or sub monolayer films). Two notable examples include  the problem of intramolecular vibrational energy redistribution and the dynamics of