RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Unravelling Spatio-temporal Auxin Intracellular Redistribution for Morphogenesis (STARMORPH)'.

assistant: **Innovation**

STARMORPH is a ground-breaking endeavour with the ambitious goal of understanding plant organ morphogenesis, which will pave the way to engineering plant growth. This is of paramount importance for enhancing agricultural and forestry yields and hence contributing to global food security and environmental sustainability. Plant organ morphogenesis involves differential growth, where various organ parts expand at different rates to create specific structures. A significant challenge lies in understanding these differential growth programs while considering the mechanical constraints imposed by the tissues. The plant hormone auxin plays a central role in differential growth. It forms concentration gradients within tissues, dictating the direction and rate of cell expansion. Mechanistically, auxin can either repress or promote growth in a tissue and concentration-dependent manner, but this biphasic behaviour remains largely unexplained. The extracellular space, cytosol, and nucleus have distinct auxin perception mechanisms and hence STARMORPH pitches an ""auxin signature"" concept, considering nuanced auxin levels in each compartment specifying an ensemble signal with quantitative and qualitative cell responses for morphogenesis. Currently, auxin subcellular compartmentalisation is poorly understood, and a key focus of the project is to provide a subcellular map of auxin dynamics within a growing organ to uncover how tissue mechanics interact with auxin-dependent growth processes, which will be pivotal for understanding plant morphogenesis. The STARMORPH project leverages a unique combination of plant, cell and synthetic biology, genetics, biophysics and organic chemistry expertise. This interdisciplinary collaboration aims to dissect plant morphogenesis from molecular to or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanical Targeting as an Integrative Approach for Personalized Nanomedicine' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The ability to direct drug delivery to specific tissues is a central challenge in treating diseases as it determines the balance between drug selectivity and toxicity. Clinical drug failures, commonly due to safety issues or poor efficacy, are extremely costly to the pharmaceutical industry. In light of this, there is a global effort to develop Targeted Drug Delivery Systems (DDS) and Nanomedicine-based drugs to increase the therapeutic efficacy of a drug while substantially reducing its off-target exposure. In oncology, this issue is critical since chemotherapies have poor selectivity, thus causing severe side effects due to undesired systemic exposure. However, the enormous heterogeneity and dynamic nature of tumors makes it extremely challenging to identify universal target molecules. In this ERC I introduce a novel concept according to which the specificity of DDS can be dramatically enhanced by tuning the physical parameters of DDS based on mechanical cues of target and non-target cells. In many cancers, it is well-established that the flexibility and deformability of cells are correlated with their metastatic potential. This leads to our hypothesis that the enhanced deformability of cancer cells allows them to engulf and uptake particles whose internalization requires massive shape change, unlike the stiffer and normal cells. The rationale of the proposed study is that by considering physical parameters of cells, the mechanical properties of DDS can be tuned to achieve selective uptake. We thus propose to develop tools for rational design of DDS for personalized nanomedicine that will use simple tests performed on a patient’s own cells. This is the basis of our visionary Mechanical Targeting (MT) scheme, a crosstalk between experimental and computational models, f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Corporate Arbitrage and CPL Maps: Hidden Structures of Controls in the Global Economy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Political science conceptualises state-market relations as balancing acts between the public sphere (the state or government) and the private sphere (the market, dominated by large corporate bodies). The expansion of the global market has been led by the rise of large and highly mobile multinational firms. Since many of these companies command turnover comparable to the GDP of middle size states, globalisation is often seen as a global shift of power from states to markets, where corporate power stems from centralisation of resources, capital and structural influence over politics and society.     Yet over the past three decades, large firms have been strategically dividing themselves into hundreds and even thousands of multi-unit, multi-layered and multi-jurisdictional cells. Typically constructed to maximise flexibility and opportunity, such de-centring of the global firm over time has increased, not decreased, the power of the corporation in world politics, society and economy. Such practices amount to a new dimension of corporate power, arbitrage power, which is the main concept underpinning this project. Arbitrage power can be defined as the capacity of economic agents to capitalise on the gaps in the institutional and legal framework of the global economy. Traditional approaches to power analysis which conventionally prioritise individual agents or clusters of interests, are of limited help when engaging with the complex ecology of a de-centred firm.   CORPLINK has two aims: a) to develop a theoretical framework to study the processes of ‘arbitrage power’ as a distinct facet of economic power; b) to develop a novel transferable methodology for the investigation of corporate arbitrage power, CPL maps (Corporate Processes and Linkages maps).  Specifically, the proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The rise and fall of metastatic clones under immune attack' under Horizon 2020.

assistant: **Concept**

Colorectal cancer is the second most common cancer in Europe, and although screening has drastically increased survival, a fraction of patients still develops metastatic disease. These patients have a 5-year survival rate of 14% compared to 70% for those non-metastatic (SEER 18). For the majority of cases, the primary tumour is successfully resected, but disease relapse arises due to undetectable metastases. How metastatic clones arise within the primary tumor and adapt to their microenvironment acquiring the capacity of colonize new niches remain unknown. In this project, we aim to use evolutionary analysis combined with state of the art high-throughput technologies to analyse the relationship between the immune system and the progression to metastatic disease. Recently,  Zapata and colleagues analysed the relationship between natural selection and the immune system using more than 20 publicly available cancer datasets. The results demonstrated that the presence of neoantigens in the course of tumour development is constrained by the strength of immune activity (immunoediting). In metastasis, malignant clones must escape immune surveillance to colonise new environments. Therefore, we hypothesize that the presence of neoantigens under negative selection in primary tumours will inform us of the cancer cells' ability to disseminate, and ultimately, settle in distant niches. To test our hypothesis, we will develop a patient- specific method to quantify immunoediting across three different cohorts of primary-metastasis matched samples. Ultimately, the extent of immunoediting can be used to explain the underlying causes of metastatic progression allowing, in the future, the development of better treatment strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Digital Culture Forum' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

DigiCULT Forum will monitor and assess the research and technological developments in and for the cultural heritage sector in Europe. A pool of over 50 culture and technology experts will build a top-class forum to discuss and analyse, in thematic meetings current and future trends in technology domains that are considered vital for the cultural sector. Accompanied by scientific studies (technology watch) DigiCULT Forum will facilitate and stimulate (future) cross-sector, cross-boarder co-operation of concerned cultural institutions, industries and policy makers. DigiCULT Forum will produce print and electronic products to disseminate its findings, recommendations and best-practice-examples as widely as possible to enhance awareness and to facilitate the early take up and implementation of new technologies and services in the cultural domain.DigiCULT Forum will monitor and assess the research and technological developments in and for the cultural heritage sector in Europe. A pool of over 50 culture and technology experts will build a top-class forum to discuss and analyse, in thematic meetings current and future trends in technology domains that are considered vital for the cultural sector. Accompanied by scientific studies (technology watch) DigiCULT Forum will facilitate and stimulate (future) cross-sector, cross-boarder co-operation of concerned cultural institutions, industries and policy makers. DigiCULT Forum will produce print and electronic products to disseminate its findings, recommendations and best-practice-examples as widely as possible to enhance awareness and to facilitate the early take up and implementation of new technologies and services in the cultural domain.OBJECTIVESThe aim of DigiCULT Forum is to function as stimulus for enhanced future R&D in th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Early Modern European Drama and the Cultural Net' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The project pursues a historical and a theoretical objective. First, it aims at giving a comprehensive analysis of (Western) European early modern drama as the first phenomenon of mass media in human history. Second, it aims at exploring the explanatory value of the metaphor of culture as a net. In that period, drama as performance casts the basis of modern mass media; it establishes for the first time in human history the cultural practice of a public visual culture that is not bound to ritual patterns and the ensuing constraints. In terms of theory, the project will investigate the productivity of the metaphor of culture as a net. A net is a non-hierarchical structure without a centre. There is no entelechical form of a net. Nets are never complete. Nets may thus extend and branch out to regions which are completely unknown to those who set them up initially. Since they are constructed by humans, nets are subject to human will as to their transport capacity. Material may be allowed to float freely or it may be submitted to scrutiny. The control logic may be belief-driven, power-driven or money-driven. The floating material may circulate in different degrees of formal organization. The outlined approach will open up perspectives for investigating European drama beyond the boundaries of national cultures. Transculturality will thus be considered to be the standard case, while nationality of cultural artefacts will be considered the particular case. Common traits between texts/ cultural artefacts stemming from different eras or from different areas will no longer be difficult to explain. Reception in later times or in other regions can be accounted for with regard to the aforementioned three basic control mechanisms. Basic formal standards, whose accomplishment can be ob
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Functional impact of alternative splicing coupled to nonsense-mediated decay in developing neurons'.

assistant: **Concept**

Differentiation of precursor cells into mature neurons relies on transcriptome-wide changes in gene expression that have to be coordinated in a precise spatiotemporal fashion. Alternative pre-mRNA splicing coupled to nonsense-mediated decay (AS-NMD) is a widespread post-transcriptional mechanism known to orchestrate gene expression dynamics in developmental contexts. Earlier studies identified several neural targets of this pathway; however, in most cases, the extent to which AS-NMD contributes to the overall gene expression dynamics and biological significance of this regulation is poorly understood. Moreover, whether AS-NMD target repertoire undergoes considerable changes in developing brain and how this might fit to the global regulation network underlying neuronal differentiation remains unclear. I will address these questions using two separate approaches. First, I will investigate novel AS-NMD targets encoding actin cytoskeleton factors and controlled by an important regulator of neuronal alternative splicing, Ptbp1. I will elucidate the extent of AS-NMD regulation in these genes by modulating the inclusion of the NMD-promoting exons with corresponding antisense oligonucleotides. in mouse embryonic stem cells undergoing neuronal differentiation, neural stem cells and primary neurons. Second, I will systematically analyse how NMD contributes to different stages of neuronal development by acutely inhibiting this pathway in a time-resolved manner using genetic means. I will then identify gene expression effects and functional consequences of NMD inactivation using transcriptome sequencing (RNA-Seq) and appropriate cell biological methods. All in all, this work will provide critical quantitative insights into AS-NMD functions and uncover novel mechanisms allowing neur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Planet Hunting: Exploration and research at the leading edge of high-contrast imaging' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

The main focus of this project is to search for extrasolar planets (exoplanets) with two innovative direct imaging surveys, designed to answer a specific list of open questions in our understanding of planet formation and evolution, and making use of the best facilities and observing methods available.The SPOTS project (Search for Planets Orbiting Two Stars), initiated and led by the applicant, will survey 67 young nearby spectroscopic binary stars in search of circumbinary planets. Such targets have been actively avoided by most previous surveys, leaving vast parts of the planetary parameter space unexplored. Through SPOTS, the applicant will establish first stringent constraints on the circumbinary planet population and conduct a statistical comparison with the large body of similar studies on single stars. Since binarity is predicted to have different effects on the two competing planet formation mechanisms, the results will provide invaluable insights on a wide range of physical processes involved in planet formation and evolution.The applicant will furthermore take a leading role in the commissioning and GTO survey of the SPHERE ZIMPOL imaging polarimeter for ESO's VLT, drawing on his years of experience in co-developing the instrument. He will employ ZIMPOL's peerless performance to search for reflected light from cold planets in the habitable zones of the most nearby stars, as well as to image the tell-tale signs of planet formation in circumstellar disks.Both surveys offer good chances of extremely high-impact discoveries (first imaged circumbinary planet, first imaged habitable-zone planet), and provide important, lasting contributions to the field even in the case of non-detection, promoting European research excellence. The projects rely on IEF mobility to co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'High wear and strength components of Aluminium-TIC (ALTIC) by conventional diecasting'.

assistant: **Concept**

The use of reinforced aluminium alloys has not been as widespread as expected from their properties. The good properties and cost of materials have been attractive to automobile manufacturers but conventional production processes of these materials have not been tested widely enough. This project has the aim of using a new metal matrix composite manufactured by Self propagating High Temperature Synthesis (SHS) that has high volume fractions of TiC particles. SHS lowers material costs, enhances castability and improves wear and strength properties. An existing prototype AI-TiC composite will be tested using gravity die casting and High Pressure diecasting. The project will test different compositions of the alloy to establish its ease of use by conventional foundry processing. It is expected to prove that the wear properties will improve significantly over conventional alloys.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Application of parallel computing techniques to models of of galactric structure and dynamics' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

I propose to study the effects of central black holes on the structure of galaxies, the evolution of chaotic orbits in triaxial potentials, stellar interactions with massive black holes and tidal distortion of dwarf galaxies. The study will involve newly developed parallel algorithms for efficient simulation of self-gravitating systems, including continuing development of new hybrid parallel algorithms and analysis tools for parallel computers. Implementation will be on Cray T3D/T3E, the special purpose HARP processor at the IoA, and the proposed Cambridge Large Scale Computing Facility. Objectives will be a survey of the orbital properties of a family of triaxial galaxy models, with a central black hole, comparison with observations, and efficient implementation of new parallel algorithms. Specifically, I will port a Poisson solver to the T3D/T3E and hybridise the code with a direct N-body solver using the HARP, and develop associated parallel and serial analysis software.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'AUTOPHAGY AND VIRULENCE OF HEPATITIS C VIRUS' to be submitted under Seventh Framework.

assistant: **Abstract**

Autophagy is a major intracellular pathway for cellular homeostasis. It also plays an essential role in antiviral response against diverse pathogens. Indeed, in addition to the removal of viral protein aggregates from the cells, autophagy is emerging as a key regulator of viral propagation by regulating positively or negatively the secretion of interferon α/β (IFNα/β) and inflammatory molecules, known to be essential to initiate antiviral responses. However, certain pathogens such as, for example, the hepatitis C virus (HCV), which chronically infects over 130 million peoples in the word and thus has a substantial impact on public health, have developed mechanisms to inhibit the completion of autophagy. Moreover, we demonstrated that HCV even uses autophagy proteins for the translation of incoming viral genomes in newly infected cells (Dreux et al., PNAS 2009). Thus, this CIG proposal is based on our princeps data and aims at determining the functional relationships between autophagy and HCV. Therefore, we will define the molecular mechanism whereby HCV co-opt the autophagy regulators to initiate the translation of its genome. In addition, we will decipher the mechanism of inhibition of autophagy completion by this virus and its impact on viral replication. Furthermore, we will analyze the regulation by autophagy proteins of antiviral molecules production during HCV infection. Finally, this project will entail at determining the role of autophagy-virus interplay during in vivo infection using mice reconstituted with a human liver that we recently established in the lab and that are robustly susceptible to HCV infection. Those complementary analyses will permit to further understand the regulation of viral infection by autophagy and will contribute to the design of bette