RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Contribution of RXRs to myeloid cell biology: from hematopoietic stem cells to osteoclastogenesis' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Hematopoietic stem cells (HSCs) yield blood precursors devoted to unilineage differentiation and production of mature blood cells, including red blood cells, megakaryocytes, lymphocytes and myeloid cells. Precursors of the myeloid lineage differentiate into monocytes and granulocytes but at given stages of their maturity they can be also sources of multinucleated osteoclasts. Consequently, any altered myelopoiesis can be directly linked to deficiencies in osteclastogenesis and impaired bone homeostasis. Retinoic X receptors (RXRa, RXRb and RXRg) are members of the nuclear receptor family. They appear to contribute to hematopoiesis and osteoclastogenesis via their roles as heterodimeric partners of several nuclear receptors. Functionally the most important isotype is RXRa during morphogenesis. Since RXRs can function either as homodimers or heterodimers, it is unclear whether the effects of RXRs on hematopoiesis and osteoclastogenesis are coupled to RXR homodimers, heterodimers, or involve the regulation of parallel pathways. Additionally, in mouse models of RXRa deletion, a partial redundancy in RXRa, b and g functions can be also observed. In this context, the goal of the presented project is to characterize the role of RXRs in HSC differentiation and osteoclastogenesis. In this project we will work with a knockout mouse model in which both RXRa and RXRb are selectively ablated in the hematopoietic system. Using this model we will be able to characterize the in vivo effects of the conditional inhibition of RXRa and b in the murine hematopoietic system and we can clarify the contribution of each isoforms to myeloid cell differentiation and osteoclastogenesis. The results are anticipated to open new perspectives for developing stem cell based therapies for the treatment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Variability in Relativistic Jets: the Fastest Time Scales at all Wavelengths'.

assistant: **Concept**

I propose to fully harness a new exciting window recently opened in Astrophysics, which I am pioneering: the study of multi-lambda fast variability from relativistic jets from stellar-mass compact objects. I will (a) identify and apply strategies to maximize the scientific output of a large amount of data, and formally define and publish new standard methods for multi-lambda statistical and timing analysis, to serve as points of reference for future works; (b) initiate an ambitious numerical code for the variable emission from a relativistic jet from a stellar-mass compact object; (c) apply the above techniques and codes to a large amount of data, placing unprecedented constraints to the physics of jets, and comparing the jet properties in black holes and neutron stars, ultimately answering the fundamental question about how the jet properties are influenced by the presence of a hard surface or an event horizon (and/or ergosphere), as well as by the presence of large-scale bipolar magnetic fields. I am one of the precursors in this field, which has already shown its large potential. I have built and am currently a leading member of a large international collaboration, which has acquired a large amount of data with the most diverse sets of observational facilities and data structure. The complexity of the field, together with its clear potential, demands a focussed and continuous effort, which I am planning to take. I will tackle the objective with a multi-disciplinary approach, working on observations, theory and numerical simulations, maximizing the scientific exploitation of the method. I have been hired recently by the host institution with a researcher permanent position, which guarantees my stability during the project and the feasibility of the project itself. As
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Carbohydrate metal complexes as photo chemotherapeutics and radiotracers for the treatment and visualisation of cancer' to be submitted under Sixth Framework.

assistant: **Abstract**

The specific and multivalent saccharide-receptor interactions opens a new way of drug targeting to specific cells and introduction of very active metal complexes with a high potential for medical applications by unifying them with carbohydrate moieties. CARBOMETCOM includes two different approaches combining the positive attributes of both transition metal complexes and carbohydrates in order to achieve novel selective photo chemotherapeutics and contrast agents.The first concept is the synthesis of carbohydrate functionalised ruthenium complexes, which should be able to selectively infiltrate or bind onto cell surfaces depending on the type of sugar substitution. Novel coupling reactions for the formation of saccharide substituted metal complexes will be developed. The obtained complexes will be incubated with HeLa cells and their migration within this biological tissue will be detected.The second approach is the development of methods for the synthesis of novel tailor-made S-glycosides for the compexation of radioactive nuclides to create novel selective contrast agents. CARBOMETCOM will advance my competences particular in terms of multidisciplinarity and research management in the process of reaching a position of professional maturity and independence.Through the establishment of international collaborations I will consolidate and widen my career perspectives within the European Union. I will acquire knowledge and skills from the world leading group in the field of synthesis and characterisation of carbohydrate metal complexes and their application.The achieved results will open up new perspectives for selective drug delivery and development of new specific chemotherapeutics and contrast agents and provide the EU with new and competitive tools in the area of combat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Emerging eco-active materials by sustainable tools from natural renewable residues' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

ECOSYSTEM will develop innovative, multifunctional biopolyesters and active bio-based ingredients using sustainable technologies, to be used as mulching films and food and pharmaceutical packaging, ensuring safety and sustainability throughout the bio-based value chain. the project will offer end-of-life (EoL) strategies of the developed eco-active products, promoting eco-friendly solutions in packaging and agricultural practices. To achieve its ambitious goals, ECOSYSTEM, led by FUNDITEC (FUND), will follow a collaborative circular strategy across seven key blocks, with nine specialist partners: 1) First, Agrifood Waste Supply such as berries and pruning, will be provided by AGRICOLA 2000 (A2-I) and MOUNTAIN BERRIES (MBP). 2) Then, production of cellulose, furfural, and lignin from the above waste using an integrated biorefinery will be done by CSIC; 3) With this raw materials, aromatic and aliphatic monomers will be synthesized via mechanochemistry and white biotechnology by CSIC and FUND respectively, 4) Active ingredients with bacterial and ethylene inhibition capacity will be developed from natural resources by CSIC using mechanochemistry, and with antimicrobial and biostimulant properties by FUND through white biotechnology. Soil-sensors will be developed by DTI; 5) A catalogue of new biopolyesters will be designed and developed by FUND using mechanochemical polymerization from the prepared bio-based monomers; 6) Once biopolyesters and active ingredients are obtained, bioplastic films and packaging for food and pharmaceuticals will be manufactured by AIMPLAS ; 7) The above eco-active products will be tested in a relevant environment by A2-I and MBP, and 8) EoL Solutions will be provided: recyclability (AIMPLAS), reusability (CSIC), and biodegradability (UNIFE) for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Therapeutic Bacteria Biohybrids For Oncology Treatment'.

assistant: **Concept**

THERABOT pioneers a groundbreaking approach in the fight against cancer through the development of engineered biohybrid agents, iBots. These iBots represent a significant leap in bacterial cancer therapy (BCT), combining synthetic biology and nanotechnology to encapsulate therapeutic bacteria with protective polymeric coatings. This encapsulation aims to enhance the delivery and efficacy of bacteria to colonize tumor tissue, drastically reducing the adverse immune responses and systemic toxicity associated with traditional BCT. THERABOT's innovative strategy focuses on colorectal cancer, employing a multifaceted approach that includes the design of advanced intelligent biohybrids by programming iBots for targeted therapeutic action, and validating their effectiveness in vivo. Central to THERABOT's mission is its interdisciplinary and international consortium, comprising 12 members from 10 leading academic institutions and 2 SMEs across Europe (France, Spain and Sweden) and from non-EU countries (Japan, Argentina, Chile, Brazil and Thailand). This collaboration fosters a unique integration of diverse scientific disciplines, including bioengineering, immunology, material science and oncology, promoting the exchange of knowledge, techniques, and cultural perspectives, which is pivotal for addressing the complex challenges of developing a new cancer therapy. THERABOT not only emphasizes the scientific innovation but also prioritizes the training and career development of seconded staff, enhancing their research competencies and preparing them for future challenges in diverse fields. THERABOT's focus on developing accessible and patient-friendly cancer treatments, underscores its alignment with EU priorities in health and innovation. By redefining cancer treatment paradigms
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hybrid Learning Systems utilizing Sum-Product Networks' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

We have recently witnessed a considerable interest in probabilistic models within deep learning, leading to e.g. generative adversarial networks, deep generative networks, neural auto-regressive density estimators and Pixel-RNNs/CNNs. Furthermore, sum-product networks (SPNs) are a recent deep architecture with a unique advantage over the aforementioned models: they allow both exact and efficient inference, implemented in terms of simple network passes. However, SPNs are a constrained type of neural network and do not reach the full flexibility of the deep learning tool kit available to date. This calls for hybrid learning systems which exploit the superior inference properties of SPNs within other deep learning approaches. In this project, I will investigate two such approaches. First, I will structurally combine a deep learning architecture (front-end), which extracts a representation from a set of inputs, controlling the parameters of an SPN (back-end) over a set of outputs. This yields a hybrid conditional SPN which facilitates full inference over the output space, and which is naturally applied in structural prediction tasks. Such hybrid SPNs can be expected to be highly expressive and to set new state-of-the-art results in e.g. semantic image segmentation. The second approach is to use SPNs as variational distributions, i.e. for approximating a given target distribution by minimizing Kullback-Leibler divergence. On the one hand, this allows to capture intractable models with SPNs, with the goal to enable fast amortized approximate inference. On the other hand, this approach allows to use hybrid conditional SPNs as so-called inference networks for intractable generative models with latent variables, for the purpose of variational posterior inference and learning. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Reinforcement of research capacity in software development and innovative collaborative design and engineering in Serbia and Montenegro' under Sixth Framework.

assistant: **Concept**

Strategic objective of RRCSD INNCODE project is to reinforce S&T potential at Mechanical Engineering Faculty Kragujevac (MFK) in thematic WBC top-priority areas of Collaborative working environment, Software and services (IST) and Water management (SUSDEV), and also to create a competitive research infrastructure for efficient knowledge and technology transfer at national, regional and EU level towards integrative and enhanced ERA. This provides necessary preconditions for MFK to become a leading Centre of Excellence in the Western Balkan region.In order to achieve this strategic objective, five operative (measurable) objectives are established, as follows:- To realize modernization of research infrastructure and working environment, through upgrade and renewal of S&T equipment and organizational harmonization of three research workgroups - RWGs:- Software Development, Information technology and Virtual engineering;- To realize researchers training programme at laboratories and institutes of EU networking partners and to increase their mobility in scope of European Research Area (ERA);- To strengthen the networking and research integration of MFK with existing EU and regional partners and also with new ones;- To disseminate research results and achievements and to create efficient mechanisms for its exploitation at national, regional and European level, through organization of three thematic workshops, specialized e-courses, participation at international conferences, connection with EU networks of knowledge and technology, etc;- To increase attractivity of R&D occupations and local job opportunities for young researchers, resulting in diminishing of brain drain phenomena, by providing modern working environment and their training and mobility within EU centres.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'EUROpean Tidal energy pilot farm focused on Industrial Design, Environmental mitigation and Sustainability' (EURO-TIDES) targeting Horizon Europe.

assistant: **Abstract**

There is 10GW  of predictable, high-value tidal stream energy potential in European waters, with up to 100 GW of capacity globally . This is an almost entirely unharnessed clean energy resource, with just 13 MW currently deployed . Transitioning European market leading technologies from single deployments, up to farm scale, is the next milestone in harnessing this clean, predictable, secure, domestic energy resource.  EURO-TIDES has been developed specifically to address the call topic by delivering a 9.6MW farm of four 2.4MW Orbital tidal energy devices of the same series.  The farm will operate in full operational conditions for 15 years, deploying in 2027. The EURO-TIDES consortium will work collaboratively to deliver six ambitious objectives and drive the sector forwards:1.De-risking tidal energy technology development by delivering a 9.6MW pilot farm and three pilot farm system innovations; reducing Levelised Cost of Energy (LCOE) of Orbital’s floating tidal technology from €120/MWh to <€100/MWh.2.Increase bankability and insurability by providing 17,520 hours of operational data, displaying the production of 50GWh+, and verification of key technology metrics to internationally recognised methodologies: reducing cost of capital from 10%-12% to 5%-6%.3.Increase availability of tidal stream by creating an efficient robust, replicable, and reliable operations and maintenance programme: increasing availability to 95%+.4.Improve market confidence by developing industrial design and manufacturing processes: increasing supply chain capacity from one device per annum to 80 devices per annum.5.Increase knowledge of environmental impacts to ensure appropriate environmental protection and mitigation is in place: enabling safe scalability to a 100GW+ global market.6.Making per
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Carbon Nanomembranes for Energy Storage Applications'.

assistant: **Objectives**

CNM Technologies (CNMT) has developed a highly permeable and selective composite membrane with a nanometre-thin carbon nanomembrane (CNM) as active layer, which is – in the FET-open project ITS-THIN – introduced into demanding water separation applications. CNMT plans in a joint venture with the Dutch SME BLUE-Tec (also partner in ITS-THIN) to introduce these membranes into the water filtration market. Recently, scientists at Friedrich-Schiller University Jena (FSU) showed in the framework of the Graphene FET-flagship a high proton and lithium ion permeance of CNMs. Combining these findings with the ability to produce large-area CNM-composite membranes, a fully new technology is emerging: the use of ultrathin CNMs as separator membranes or proton exchange membranes (PEM) in battery and fuel cell applications. Thinner membranes promise a faster and more selective ion transport resulting in smaller, more powerful, and more reliable energy storage devices. This new window of opportunity will be explored in this feasibility study. In case of a positive outcome, CNergy will result in a business and action plan, how to introduce CNMs into batteries and fuel cells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Illuminating aptamers and ribozymes for biomolecular tagging and fluorogen activation' (2014-2020).

assistant: **Innovation**

RNAs are linear biopolymers that consist of only four types of building blocks, but can fold into complex three-dimensional structures that are endowed with selective, high-affinity ligand-binding abilities known as aptamers, and catalytic activities known as ribozymes. Genome projects have brought the surprising insight that a large part of the human genome is transcribed into RNAs, but only a very small fraction is translated into proteins. The actual number of noncoding RNAs with specific functions is currently unknown, but many are considered as prominent regulators of cellular functions. Posttranscriptional modifications of RNA add an extra layer of complexity, but their regulatory roles in RNA metabolism are only poorly understood. Despite the relative simplicity in molecular composition, the available methodological repertoire for manipulation, interrogation and visualization of RNA is rather limited. This project aims to solve the challenge of RNA labeling in both fixed and living cells, using aptamers and ribozymes for RNA imaging and functional characterization. We introduce the term illumizymes for novel tools that attach bio-orthogonal tags and fluorophores to specific RNA sequences, in vitro and in vivo. Ribozymes and aptamers for small, stable, and specific labels will be identified by in vitro selection and systematic evolution of ligands by exponential enrichment (SELEX) to activate the fluorescence of latent chromophores by restricting their conformational flexibility and/or formation of covalent bonds by new bio-orthogonal reactions. Using naturally inspired, cell-permeable and non-toxic ligands, we will specifically select for increased brightness and photostability, and evolve illumizymes into color-switching probes for RNA microscopy. The new geneti