RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A range of economically viable, innovative and proven HydroKinetic turbines that will enable users to exploit the huge potential of clean, predictable energy in the world’s rivers, canals and estuarie'.

assistant: **Innovation**

The DP Renewables project aims to commercialise a range of innovative, hydrokinetic turbines that will offer a reliable solution for generating zero-carbon energy from rivers, estuaries and canals. The range of products to be launched on the market in February 2020 comprises of two different sized turbine devices, 25Kw and 60Kw respectively, which are specifically designed to cater to a niche, ‘low-power’, small-scale energy generation market.DP Renewables stems from the success of ‘HydroKinetic-25’, the SME Instrument Phase 1 project implemented by DesignPro in March-September 2016 that served to prove this innovative idea’s economic viability and define a business plan to bring it to market. Phase 2 will see this strategic and validated business plan implemented and the realisation of a project that will have significant positive impact on societal, economic and environmental issues. The project will cater to those with a suitable deployment site, meeting their need for energy security and independence, reducing reliance on imported fossil fuels and lowering carbon emissions. The project is fully aligned with the growth strategy of the SME and is regarded as a major stepping-stone towards consolidating its international presence while becoming a recognised contributor to the renewable energy spectrum. Despite its large resource potential, hydrokinetic energy is still largely untapped with only 5% exploited to date. Europe, as well as many countries around the world, is rich of small and medium-sized rivers and straits between islands. Existing technologies require very fast flow speeds and large deployment spaces in order to make turbine outputs viable. This cuts off a large majority of the available market from having a feasible solution to use. Our project, DP Renew
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Impacts and risks from higher-end scenarios: Strategies for innovative solutions' (IMPRESSIONS).

assistant: **Concept**

IMPRESSIONS will provide empirically-grounded, transformative science that quantifies and explains the consequences of high-end climate scenarios for both decision-makers and society. IMPRESSIONS will develop and apply a novel participatory methodology that explicitly deals with uncertainties and strong non-linear changes focussing on high-end climate change, but also including intermediate warming levels. This new methodology will build on the representative concentration pathways (RCPs) and shared socio-economic pathways (SSPs) to create a coherent set of high-end climate and socio-economic scenarios covering multiple scales. These scenarios will be applied to a range of impact, adaptation and vulnerability models that build on theories of complex systems and address tipping elements as key characteristics of such systems. The models will be embedded within an innovative multi-scale integrated assessment approach to improve analysis of cross-scale interactions and cross-sectoral benefits, conflicts and trade-offs. Model results will inform the development of time- and path-dependent transition pathways. These will include mechanisms to foster synergies between adaptation and mitigation and will aim to build resilience in the face of uncertainty. Methods will be applied within five linked multi-sectoral case studies at global, European and regional/local scales. Stakeholders within these case studies will be fully engaged in the research process through a series of in-depth professionally facilitated workshops which maximise their active participation in defining high-end scenarios and adaptation and mitigation pathways, and in analysing the inherent risks and opportunities of new policy strategies. This will build the capacity of stakeholders to understand the risks,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'To decipher the optimal management of systemic sclerosis' in the context of a Seventh Framework call.

assistant: **Objectives**

The current approach to diagnosis and management of the rare disease systemic sclerosis (SSc) is based on American College of Rheumatology criteria with low sensitivity and few validated recommendations for the therapy of the disease and its manifold organ manifestations. To overcome these shortcomings, the DeSScipher project will use the multinational, prospective and open EUSTAR (Scleroderma Trials and Research group of the European League Against Rheumatism) SSc cohort based on the established MEDSonline database which covers >30 data items and will evolve into a multimodular tool to answer step-by-step all immanent questions in a long-term setting according to the nature of the disease. The resulting progress will address functionally disabling manifestations affecting the hands (digital ulcers and arthritis), and compare the efficacy and safety of off-label drugs in the treatment of vital organ manifestations. Specifically, the DeSScipher project will evaluate (i) the utility of a combination of easy-to-perform clinical and laboratory investigations in combination with capillaroscopy for identifying SSc patients at risk for the development of digital ulcers at an early stage (ii) the prevention and treatment of digital ulcers and hand arthritis in order to improve long-term disability and quality of life, (iii) the efficacy of different immunosuppressive agents in attenuating or inhibiting pulmonary fibrosis, (iv) the optimal treatment options for reducing morbidity and mortality of pulmonary hypertension and severe heart disease in SSc. Based on the results of these observational trials, the DeSScipher project will develop evidence-based clinical guidelines for the future management of adult and juvenile SSc to be disseminated widely and rapidly to physicians and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Genetic diversity in the European lobster (Homarus gammarus): Population structure and impacts of stock enhancement.', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

To develop and test microsatellite and mitochondrial DNA markers and to optimise screening conditions to enable high-resolution studies of European lobster genetics.To determine intra- and inter-population genetic diversity based on microsatellite, mitochondrial DNA and allozyme markers in samples from throughout the range of the European lobster.To evaluate the use of genetic tagging for determining the contribution of ranched individuals in mixed wild and ranched harvests and to determine the potential genetic impact of stock management and enhancement on natural populations.To determine the paternity of egg masses from individual females and thus elucidate the breeding structure in various European lobster populations.To produce a plan for the conservation and management of genetic resources in European lobster fisheries taking into account natural population diversity, extant industry practices, previous and current enhancement activities, and the future potential for farming and or ranching.METHODOLOGY AND RESEARCH TASKSThe overall methodology relies on the development and optimisation of microsatellite and mitochondrial DNA markers for the European lobster and of the large-scale screening of these markers using manual and automated gel electrophoresis systems. These genetic markers will be used to quantify population genetic variation in samples of lobsters obtained from throughout the geographical range. The genetic markers will also be tested as a means of differentiating between wild and stocked individuals. Microsatellite DNA profiling will be used to determine paternity in egg masses from individual females. Genetic data will be used to produce detailed recommendations for the management of the European lobster resource.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development and design of a novel industrial energy-dispersive x-ray reflectometer for analysis of liquid and solid superfaces and interfaces' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The aim of the work is to transfer the well-known energy-dispersive time-of-flight neutron reflectometry technique to a X-ray reflection technique. Based upon this measuring method a novel, industrial energy-dispersive X-ray reflectometer should be developed. Using this novel X-ray reflectometer faster analysis of thin film systems should be possible compared to nowadays used angular-dispersive X-ray reflectometers. This new reflectometer will be based on the already commercially available angular-dispersive industrial Siemens D5000 X-ray reflectometer with laboratory sealed X-ray tubes. Because of faster measuring times and other specific advantages this new reflectometer will be a suitable tool to study in situ structural changes at surfaces and interfaces and respectively to allow fast routine process controls in glass industries or in semiconductor industries which is not possible with already commercially available X-ray reflectometers. The development will be done in close collaboration with Siemens Analytical X-ray Instruments, development department, Siemens AG, Karlsruhe (DE). (148 words)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Life in Arsenic rich environments: a challenge or an opportunity?' to be submitted under Horizon 2020.

assistant: **Abstract**

Arsenic is a notorious toxin, and as such may have exerted a strong selective pressure on the distribution and evolution of life on Earth. Despite evidence supporting the high levels and prominent role of As on the primitive Earth, the essentiality and toxicity of As, and its impact on evolutionary processes remains unexplored. AsLife aims at taking a novel approach to assessing microbial As cycling by exploiting two linked «environments». The first are the microbial mats from High-Altitude Andean Lakes, where it is known that As concentrations are far above background levels. Specifically, living and diagenetically-modified microbial mats will be investigated using scanning hard X-ray nanoprobes emerging at synchrotron facilities. This non-invasive and non-destructive technique provides data on a sub-micrometer scale by which to tie physiological inference from trace metal(loid)s distribution and speciation patterns directly to the microfossil biomass. Thus, providing a means to understand the interplay between microbial metabolisms and bio-availability of trace metal(loid)s in living and fossil ecosystems. The second environment comprises laboratory cultures, using the sampling power of «adaptive laboratory evolution» to explore how microbes adapt and enhance As detoxification facing the extreme As levels present in Andean Lakes. These results will be discussed in light of genomic studies of As-rich microbiota performed by Argentinian colleagues. During this project I will contact colleagues of the Jet Propulsion Laboratory in charge of the 2020 Mars Science Rover Mission and linked objective of returning samples for future analysis on Earth. I believe that my expertise in imaging and analyzing bio-geochemical proxies at multiple scales on a encapsulated geological sa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Role of Complex I Assembly Factors during Prion Diseases: Insights into Mitochondrial Neurobiology' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Mitochondria have a crucial role in cell survival and apoptosis, in particular in long-lived cells such as neurons. Mitochondria generate energetic potential through respiratory complexes I to IV, which constitute the electron transport chain. A number of studies demonstrates that mitochondrial integrity declines as a function of aging and dysfunctions may be exacerbated by age-related neurodegenerative diseases. Altered levels of complex I proteins have been found to be directly responsible for a decrease in energy production in Alzheimer’s and Parkinson's disease. Recently, a number of nuclear encoded mitochondrial proteins, denoted as “assembly factors” (AFs), have been identified as crucial components helping the complex I assembly. Defects in AFs (due to mutations or aberrant AFs processing) may cause complex I misassembly and mitochondrial dysfunctions leading to a broad spectrum of diseases, including neurological disorders in childhood-related dieseas as Leigh syndrome. The functional role of AFs during neurodegeneration has not been investigated yet. With the “Prion Respiration” project I propose to develop a research approach aimed at the identification of the biological role of three crucial complex I AFs (namely ECSIT, NDUFAF1 and ACAD9) in cellular and animal models using prion diseases as robust system to study neurodegenerative diseases. Subsequently, the role of prions in interfering the with the correct assembly of the AFs will be investigated using structural biology approaches, as SAXS and cryo-EM methods. The structural and functional characterization of key proteins involved in mitochondrial respiration will provide insights into the underlying mechanisms involved in neuronal function and may represent novel targets for structure-based drug design s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Linkage disequilibrium in European populations'.

assistant: **Objectives**

Knowledge of the extent of linkage disequilibrium (LD) and its variation across the genome is required for the efficient and systematic implementation of mapping functional polymorphisms implicated in common, complex disorders.. The overall goal of this project is to determine extent and variation of LD in the genome of the general population of European populations. DNA from population samples of unrelated individuals will be typed with some 250 micro satellites and SNPs in nine genomic regions and the entire chromosome 22 (C22). The extent of LD will be measured for each region and for C22, and will be compared across populations. The across-population variability of extent of LD will be interpreted by the demographic history of each population. Each genome region will be compared for extent of LD across chromosomes and between populations. Inherent genome, sequence-related characteristics will be used to interpret regional variability. Regions harbouring genes implicated in complex disorders will also be studied. Frequencies phaplotypes extending across each genomic region will be estimated for each population. Computer programs used for data analysis and all DNA types generated in this project will be available to the public at the completion of this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Investigation into the monitoring analysis and toxicity of toxaphene in marine foodstuffs', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Current available information suggests that a number of fishery products, from European marine waters, may exceed the recently revised German tolerance level for toxaphene residues. The new German tolerance level will be 0.1 mg kg-1 wet weight for the sum of three indicator congeners. While it is essential that the threat to the consumer from toxaphene residues in fishery products is fully understood and quantified, tolerance levels should only be applied with sound scientific advice. At the moment a sound scientific toxicological basis for this tolerance levels does not exist. The tolerance level could result in a serious trade ban should other member and non member countries apply a similar tolerance levels.The current project brings together an interdisciplinary group of scientists with expertise in analytical and environmental chemistry, toxicology, fisheries biology and statistics. This group will focus their investigations on i) analytical methods for toxaphene analyses, ii) monitoring of toxaphene levels in European fishery products and spatial distribution of toxaphene in European waters and iii) the carcinogen city of toxaphene and the effect of environmental transformation on the toxicity of toxaphene. This will provide essential management information on: i) the magnitude of existing or potential problems with regard to toxaphene ii) the most efficient and cost effective approach to monitoring iii) the real toxicological risk to the consumer and iv) possible tolerance levels for toxaphene in fish tissues.The first half-year of the MATT project was primarily spent on planning and on writing of the literature review on the developments in toxaphene analysis, new environmental data and toxicological developments, particularly during the last 5 years. The analyti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Participatory Urban Living for Sustainable Environments' to be submitted under Horizon 2020.

assistant: **Abstract**

PULSE (Participatory Urban Living for Sustainable Environments) will leverage diverse data sources and big data analytics to transform public health from a reactive to a predictive system, and from a system focused on surveillance to an inclusive and collaborative system supporting health equity. Working within five global cities, PULSE will harvest open city data, and data from health systems, urban and remote sensors, personal devices and social media to enable evidence-driven and timely management of public health events and processes. The clinical focus of the project will be respiratory diseases (asthma) and metabolic diseases (Type 2 Diabetes) in adult populations. The project will develop risk stratification models based on modifiable and non-modifiable risk factors in each urban location, taking account of biological, behavioural, social and environmental risk factors. Following the recommendations of WHO Europe (2015), the project will also focus on the development of metrics, and data-driven approaches, to community resilience and well-being in cities. Deploying a Health in All Policies (HiAP) perspective, and a ‘whole-of-city’ model, the project will integrate and analyze data from the health, environment, planning and transport sectors in each city. PULSE will pioneer the development and testing of dynamic spatio-temporal health impact assessments using geolocated population-based data. PULSE will also develop simulation models of potential policy scenarios to allow decision-makers, citizens and businesses to ascertain the impact of proposed policies. The project will culminate in the establishment of Public Health Observatories in each urban location. These observatories will serve as linked hubs that utilize knowledge-driven processes and big data to shape