RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Therapeutic Artificial Cells based on Molecular Cages for Glioblastoma Treatment' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Cancer is still a major societal challenge, as reflected by the Horizon's Europe mission on cancer and the Europe's Beating Cancer Plan. In particular, despite great advances in cancer treatment in recent decades, glioblastoma multiform (GBM) - the most common malignant brain tumor - stills remains without an effective cure and patients die in a few months. Around 220000 people die annually worldwide from GBM and its incidence is expected to increase in Europe due to its aging population. The standard treatment relies on the systemic administration of chemotherapeutics, which has limited efficacy and causes side effects. To overcome current limitations, TherACCage will develop artificial cells based on drug-loaded molecular cages as advanced nanosystems to tackle GBM. Such artificial cells will be equipped with processing machinery resulting in advanced biocompatible nanosystems with the ability to recognize biomarkers of the GBM microenvironment and induce responsive drug delivery in situ. The project combines unique expertise of the main host lab (molecular cages: cage-like molecular architectures with an internal cavity), the candidate (nanotechnology and artificial cells) and a secondary lab (evaluation of novel anticancer therapies) to ensure fulfillment of objectives. In a first stage, the fellow will be trained in advanced organic chemistry for the synthesis of degradable drug-loaded molecular cages. In a second stage, the assembly of artificial cells with molecular cages and their in vitro evaluation will be carried out. Finally, the fellow will carry out a secondment in a biological lab for the pre-clinical evaluation of the developed nanosystems. Importantly, the project will also allow the fellow to gain experience in patenting and tech transfer. Altogether,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Disrupting the global e-mobility sector by production of application-specific rotors for the automotive industry with an innovative and unique vertical laminar squeeze-casting process' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Breuckmann is a traditional casting company, which was founded in 1966. The company is worldwide known as specialist for casting in metallic moulds at temperatures >1000°C and developed to one of the most innovative casting companies in Europe.In recent years, Breuckmann developed an innovative vertical laminar squeeze-casting process. By the developed vertical laminar squeeze-casting process, an even laminar form filling without the formation of melt fronts is realised. This enables the production of high-performance cast rotors for automotive industry with minimal porosity, high conductivity and excellent properties for use in high speed concepts. In accordance to the requirements and the specific scopes of application in automotive sector, the high-performance cast rotors can be produced with pure copper for efficiency optimised drives, pure aluminium for weight and cost optimised drives and copper alloy for highest speed concepts. By the innovative casting technology, an innovative tool concept and a ceramic coating system, a high level of automation can be achieved and the quality requirements in automotive industry can be met. Due to this the, expansion of electric vehicles with asynchronous motors receives a decisive boost. This means the substitution of permanently excited synchronous motors and the avoidance of rare earths. The global market for electric vehicles is a very strongly emerging market, estimated to grow rapidly at a CAGR of 35% with over 60 million expected car sales in 2040 and expecting to boom in the 2020s. The distribution of the future players in the e-mobility market will be now and will have taken place in the next 3 to 5 years. Due to this, Breuckmann is willing to join forces to establish a strong market position in the e-mobility sector n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Evolution of Terrestrial Planets: Insights from Models of Planetary Evolution with Coupled Internal, Atmospheric/Surface Development' to be submitted under Horizon 2020.

assistant: **Abstract**

It is critical to integrate knowledge from multiple disciplines in order to gain a better understanding of the Earth and other terrestrial planets evolution, as well as the effects of this evolution on the expression of surface tectonics. While plate tectonics is currently observed on Earth, both its onset and length of activity are uncertain. Here we will use models of planetary evolution to begin to understand the implications for coupled internal/surface processes through changing lid states over planetary timescales (e.g. C, H2O, and O2, cycles, generation of atmosphere, dynamo generation, and coupled lithosphere-asthenosphere evolution). Further, the internal chemical composition, heterogeneities, and initial conditions within the mantle may be critical factors in setting the evolutionary path of a planet, as such we will determine what role these heterogeneities may play in the evolution of the planet. Finally we seek to understand the controls on the dynamics of a transitional episodic-lid, a state suggested for the early Earth, such as its onset, duration, recurrence interval, and location of overturns, and use these results to assess the implications for planetary development (e.g. dynamo heat flow, generation of atmosphere). This work will begin to address the following open questions: (A) What role does the coupling of internal and surface processes have through changing lid-states? (B) What role do heterogeneities (in viscosity, radiogenics and composition) play in the evolution of the planet? (C) What controls the dynamics of the enigmatic transitional episodic-lid?


**Keywords:** Plate Tectonics,  Planetary Evolution,  Dynamics,  Habitability
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The role of autophagy in presynaptic protein turnover'.

assistant: **Innovation**

Neuronal communication primarily occurs at synapses. Recent studies have suggested a key role for protein synthesis and degradation in the regulation of synaptic structure, function and plasticity by changing the abundance of select synaptic proteins in a spatially confined manner. Remodeling of the synaptic proteome is accomplished by, for example, regulated degradation via the ubiquitin proteasome system or by autophagy. Autophagy has been shown to modulate synaptic vesicle numbers and neurotransmission, yet its exact role in the regulation of synaptic function is poorly understood. The proposed project aims at the dissection of the role of autophagy in synaptic protein turnover. Using combined genetic, biochemical, molecular and cellular biology approaches as well as cutting-edge imaging in neurons I will identify presynaptic proteins that are regulated by autophagy and will define the contribution of autophagy to synapse composition and function. Furthermore, I will determine which mechanisms underlie the selective targeting of presynaptic proteins to the autophagy pathway. Taken together these studies will contribute fundamental knowledge about autophagy in neurons and will provide new insights for understanding how autophagy contributes to synaptic plasticity and protein degradation in health and disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Training NETwork on Functional Interfaces for SiC' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The main scientific objective of NetFISiC is to provide Silicon carbide material (of various polytypes) with improved and adequate functional interfaces for getting a step forward in electronic devices performance. Research efforts will be dedicated to solve the problems faces by important devices like MOSFET and Schottky diodes. Besides, some fundamental research will be performed both on the growth aspect and on new and innovating devices. Applications in high temperature, high power and harsh environment are targeted.Based on this research program, the ambitious target of NETFISiC is to train the next generation of researchers on various semiconductor related fields (such as physics, material science and engineering), taking the emerging SiC technology as an appropriate tool for study. This shall contribute to long-term strengthening of the European position on a technologically important semiconductor.13 ESRs and 2 ERs will be recruited and trained within this network, on multi-disciplinary subjects like material growth, characterization and devices fabrication, with a particular focus on SiC.NetFISiC consortium is mainly composed (11 out of 12) of the members of the presently running Marie Curie RTN ""MANSiC"" (MRTN-CT-2006-035735). The 12 partners of NetFISiC include 3 companies (SiCED, ACREO and NOVASiC). One associated partner (LIP company) will complement the consortium by providing key training offer and administrative/management assistance. Obviously NetFISiC network will be efficient from its beginning, with members having a very good experience of network implementation and functioning. On the other hand, NetFISiC will not be just a continuation of MANSiC network, which was targeting only 3C-SiC polytype, but significantly go one step beyond by focusing on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Safe and high quality supply chains and networks for the citrus industry between Mediterranean partner Countries and Europe' (EUROMEDCITRUSNET), addressing dissemination and exploitation.

assistant: **Impact**

The citrus industry's importance to the Mediterranean is clear, its countries being among the world's top producers and Europe one of the largest sumers. Increased demand in recent years has been fuelled by the promotion of fruit for a well balanced diet and sumer awareness of citrus fruit benefits. Innovation and ongoing research are necessary to further improve quality and ensure safety at all stages of the supply chain, raising competitiveness, quality of life and sumer fidence. There is a need to integrate research in this area, which the proposed project will promote using initiatives to stimulate cooperation, both internationally and between research organisations and commercial operators including SMEs, to create a network of horizontal research interest, especially for the Mediterranean region. The main project outputs will be: -A sustainable Mediterranean network for the citrus sector to support research relevant to safe and high quality cross -border supply chains. A needs assessment survey to focus research and development on improving safety and quality including policy recommendations and an action plan of research agendas. -Targeted measures to facilitate access to knowledge, training and technology to increase SME participation in research, improve the exploitation of results, and accelerate innovation. -Mediterranean Networking initiatives to stimulate international co-operation and support policy development by integrating current related research and providing added value. EuroMedCitrusNet will explore the frontiers of knowledge in citrus sector research and closely addresses the main objectives of the Thematic Priority 5: Food Quality and Safety" as well as important needs of society (e.g. quality of life). A well balanced, multi-disciplinary sortium,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Unravelling shark ecology across extinction events with novel isotope proxies' (SHARKS) under Horizon Europe.

assistant: **Objectives**

In the midst of the “sixths mass extinction event”, shark populations are declining with severe consequences for marine communities and ecosystem resilience. Diet is a key driver of shark evolution and a predictor of their extinction risk. Conservation efforts benefit from understanding past shark trophic ecology and how they coped with previous biotic crises. New analytical achievements in isotope proxy development allow the use of fossil teeth to reconstruct the trophic ecology of pre-Pleistocene animals. Using the novel Zn isotope proxy combined, for the first time, with other innovative trophic proxies (Ca and enameloid-bound N isotopes) on the same fossil and modern tooth samples, SHARKS will investigate the factor diet for a shark’s extinction risk, as well as food web changes across extinction events. Acknowledging the trophic position as an evolving trait, the project will pioneer a temporal approach, tracking trophic ecology of shark species through time. We will combine enameloid Zn, Ca and N isotopes with conventional dietary proxies (collagen C and N isotopes) in modern marine food webs to create a template for palaeoecological applications. Using this novel multi-proxy approach, we will investigate whether the emergence of serrated teeth in the Carcharodon lineage provided an ecological advantage for the modern great white shark (C. carcharias) over its now extinct ancestor with unserrated teeth C. hastalis. We will also test, from an ontogenetic perspective, the hypothesis of dietary competition between C. carcharias and the giant Otodus megalodon as potential factor of the latter’s extinction. Finally, we will explore the impact of the Cretaceous–Paleogene extinction event (66 Ma) on the trophic ecology of sharks and food web dynamics providing a hitherto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Quantifying temporal patterns of viral mortality in soil' (MeMori), addressing dissemination and exploitation.

assistant: **Impact**

Atmospheric CO2 levels are affected by sources (industrial processes, respiration) and sinks (carbon fixation, storage of organic carbon). Viruses that infect microorganisms may play an important role in soil carbon sink properties. In soil, carbon is stored, or sequestered, by binding to minerals. Recent studies show that long-term mineral-associated matter is mostly microbial debris, and its fraction out of soil organic carbon varies by soil type. Hence, viruses that break microbial host cells create microbial debris and contribute to carbon sequestration in soil, yet are missing from carbon flux models. We lack fundamental information about the physiology of soil viruses to link viral lysis of microbes and soil carbon sequestration. Recently, we provided the first estimate of microbial mortality by viruses during soil re-wetting after the dry season, a peak time of carbon flux. Our study estimated mortality of up to 46% of cells within a week. The main knowledge gaps preventing better accuracy of mortality estimates are the average number of viruses produced per host cell and infection rates year-round. I propose to address these gaps using a combination of classic microbiology and cutting-edge bioinformatics. This project will: (1) generate physiological constraints for soil viral mortality across soil types with different amounts of microbial debris, and (2) establish a multi-year monthly time-series of viral infection dynamics of soil microorganisms. I will focus on soil viruses infecting Actinobacteriota, an abundant phylum of drought-resilient soil bacteria that experiences consistently high viral infection rates. A time-series of viral activity will place the culture-based physiological parameters within the context of spatiotemporal dynamics of the entire vira
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Active Solar Panel Initiative' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The Active Solar Initiative targets development of a fundamentally new, multi-disciplinary photovoltaic technology that will enable meeting and exceeding the year 2015 cost targets of the EU Photovoltaic Strategic Research Agenda, driving European consumer premises power generation to cost parity with grid electricity. The basis of Active Solar is a novel Parallactic Tracking technology concept that supports flat, fixed solar panels with internal concentration and dynamic sun-tracking.  Active Solar panels will be a direct replacement of the ubiquitous photovoltaic solar modules. By means of a ten-fold reduction of amount of polycrystalline silicon, costs of the Active Solar panels will be reduced by up to 3 times compared to conventional PV modules.  Unlike existing silicon-reducing technologies such as thin film panels, Active Solar panels will enable cost reduction per installed Watt without sacrificing installation area efficiency. The goals of the project include prototyping and verification of the technology, as well as development and verification of cost-efficient manufacturing techniques and dissemination of knowledge among European manufacturers. The project will also lay the groundwork for the next generation of Active Solar technology that will enable a drastic additional increase in residential solar generation efficiency through use of the highly efficient multi-junction cells in flat, fixed rooftop-mounted panels.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Molecular mechanisms of neuronal degeneration: from cell biology to the clinic'.

assistant: **Innovation**

Our objective is to create within the Community the ditions for emergence of novel therapeutic approaches to neurodegenerative disease and neurotrauma, which represent an urgent socio-eomic and human need. The NeuroNE sortium (22 academic groups, 6 SMEs and 1 management partner in 9 different countries) will take a multi-disciplinary (functional genomics and proteomics, physiology, chemistry, clinical studies) and multi-faceted (disease mechanisms, biology of cell death and survival, regeneration mechanisms, high-throughput screening, gene- and cell-based therapies) approach to this problem. Among the neurodegenerative diseases, we will focus on Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). Spinal cord injury (SCI) will be the main model for neurotrauma. NeuroNE brings together investigators from different backgrounds (basic scientists, active clinicians and therapeutically-oriented SMEs) to work at all levels on a given disease: post-genomic science, molecular and cell biology, animal models, therapeutic strategies and clinical studies. Professional project management will provide efficient integration, realization of scientific objectives and knowledge management. Common infrastructures include shared NeuroNE-funded core facilities in 7 centres, while our web-based database will serve as a European depository for biological research tools. Training will be provided at several levels: by a competitive program of multi-centre postdoctoral fellowships, by mobility of NeuroNE scientists to other centres and platforms, and by the organization of summer schools and laboratory open days. To feed back the benefits of integration into EU society, we have involved patient organizations from the start, iden