RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The study of Initial limiting steps for fimbrae assembly in E.coli' (INFIMAS), addressing dissemination and exploitation.

assistant: **Impact**

Currently, the control of infectious diseases caused by pathogenic organelles displayed on bacteria is challenging for alternatives to antibiotic treatments. In this regard, the OMS report of 2010 alerted of the raising of antibiotic resistance for the control of human infections. Many of these pathogenic organelles, also known as pili or fimbriae, are assembled by a specific secretory machinery called the chaperone-usher pathway (CU). The aim of this proposal is the study of the initial steps required for the fimbriae assembly by the CU pathway (objectibe 1 and objective 3) and the identification of sequences involved in these steps  (objective 2), using the E.coli Type 1 fimbriae prototype as the research model. The ultimate goal of INFIMAS project is the design of inhibitory peptides repertoires based on results obtained by the achievement of previous objectives, that will potentially overcome the bacterial resistance to the current antibiotics used for the treatment infectious diseases in EU and other countries.In addition, the results derived from INFIMAS project will have an additional impact on the general scientific knowledge of the European scientific community, in particular, on the study of pathogenic bacteria organelles. With regard to the fellow, the Marie Curie Fellowship will offer her the opportunity to achieve high impact publications, to be trained in complementary skills and obtain the international research experience required to reach a maturity position after the completion of the proposal, as INFIMAS project will be developed in a high reputed institution, such as The Swiss Federal Institute of Technology, and be supervised and advice by Prof Glockshuber, a well known expert in the field of pathogenic organelles using Type 1 fimbriae of E.coli as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'biomimetic engineered chordae tendineae for valve repair and regeneration'.

assistant: **Concept**

The human heart is among those organs suffering from a limited capacity to self-regenerate. Heart diseases continue to be a leading cause of mortality with suboptimal therapeutic options. Thus, deploying new therapeutic strategies for tissue repair is a primary objective in modern cardiac medicine. Valvular heart diseases, such as those related to the Mitral Valve (MV), are the leading causes of cardiovascular morbidity and mortality worldwide, affecting 5.1% of the 65+ years old population. In particular, MV regurgitation, one of the most common valvopathies, affects over 24 million people worldwide. Since the fundamental nature of MV regurgitation is mechanical, caused by physical, irreversible damage to the restraining force structures of the valvular apparatus, the only effective treatment is limited to the surgical approaches that include MV repair or replacement. However, when the regurgitation is due to Chordae Tendinae (CT) elongation or rupture, several studies have demonstrated the substantial advantages of MV repair, using a substitute for the damaged CT vs. MV replacement. Currently, the expanded polytetrafluoroethylene (ePTFE) has become the standard approach in CT repair/replacement1. However, several complications (rupture, calcification, detachment, fibrosis, and slippage) have been observed. Hence, there continues to be an urgent need to develop better MV repair techniques that are simple, effective, and durable. In this proposal, we intend to further advance and validate BioChord, the first ever polymeric bioengineered regenerative CT, designed to first repair the MV by replacing the diseased CT, providing mechanical support to the valvular apparatus, then to be restored by the patient tissue, progressively becoming a functional tendon-like structure t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Self Assessment Towards Optimization of Building Energy'.

assistant: **Objectives**

Existing measurements of equipment and building energy use paint a bleak image: real-life energy consumption often exceeds design predictions by more than 100%. As a result, reducing the gap between designed and measured energy use has become central in current efforts to increase energy efficiency.  After the successful introduction of building energy performance certificates, the market is now ready for an assessment of real-life energy use that includes all energy consuming equipment in a given building. With this evolution comes the possibility of optimizing energy performance of the whole building and its energy consuming equipment.The SATO project tackles this challenge by (1) Creating a new energy self-assessment and optimization SATO platform that integrates all energy consuming equipment and devices in the building; (2) Developing and integrating into the SATO platform a self-assessment framework (SAF) that uses data analysis and machine learning to report energy performance, building behaviour, occupancy and equipment faults. This framework is aligned with the structure of the smart readiness indicator (SRI); (3) Developing a BIM-based interface for aggregated and disaggregated analysis and visualization of the assessments in the various applicable scales and defining locations and specifications of energy consuming equipment, sensors and actuators into a BIM building model; (4) Develop and demonstrate energy management services that use the SATO platform and show how the self-assessment and optimization contributes to lower energy consumption, increased energy flexibility, efficiency and user satisfaction.


**Keywords:** BIM, SRI, Energy, Appliances, Optimisation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Stellar Astrophysics and an Ab Initio Description of Thermonuclear Reactions' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Light-ion fusion reactions in thermal plasmas determine the course of stellar evolution. Nuclear reactions such as 7Be(p,gamma)8B, which is responsible for most of our knowledge of neutrino oscillations, the 3He(alpha,gamma)7Be identified as the most important reaction limiting the accuracy of the standard solar model, the triple-alpha fusion to form 12C and the famous 12C(alpha,gamma)16O reaction are still not known with anywhere near the required precision. Their experimental measurement at low energies relevant for astrophysics processes is very difficult or even impossible. Remarkably, no fundamental theory for these nuclear reactions exists today. It is the goal of this proposal to develop an entirely new ab initio formalism with a predictive power applicable to nuclear reactions important for astrophysics. A fundamental theory for light-ion fusion reactions presents a substantial challenge, as detailed nuclear structure information for the entire system is required. The proposed approach is based on the ab initio no-core shell model (NCSM), which is a well established theoretical framework presently capable to describe nuclear structure from inter-nucleon forces derived by means of effective field theory from quantum chromodynamics. Its extension to the description of nuclear reactions will be achieved by adopting and adapting the resonating group method technique.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Life history traits of the northwest european flora: a database' (LEDA).

assistant: **Innovation**

The LEDA Trait base program aims at a WWW-based database with a complete species-trait matrix for the northwest European flora, i.e. ca. 3000 species, open for further expansion to the whole European flora and including e-networking procedures to continue data adding after the termination of the project. The traits are related to the persistence, regeneration and mobility of plants. They will be compiled from an extensive literature review, from unpublished data and field experiments. The user can generate select species-trait matrices for local, regional, or national species pools which can be analysed with data mining tools. Case studies from several EU countries on the habitat, landscape, and national scale will demonstrate applicability. The database will allow putting species in a comparative context based on their trait attributes to extract general principles about functional plant-environment relations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A WORLD WITHOUT SCARS: Regenerating wounded skin rather than patching with scars' (ScarLessWorld) targeting Horizon 2020.

assistant: **Abstract**

Scars are a mystery. They rarely develop in lower vertebrates, where the norm is a complete regeneration of damaged tissues, but are frequent in mammals including humans. Scar phenotypes depend on different injury types, anatomic locations, age, gender and species. The natural diversity of scars includes rare cases, where damaged tissues regenerate without scarring. The scar/regeneration decision remains unresolved and scar prevention is a clinical challenge. Current research has been held up by conceptual and operational bottlenecks. The current conceptual notion comes from experiments showing that scarring depends on the internal environment of the injured organ. I challenged this notion by uncovering specialized fibroblast cell lineages that regenerate connective tissues without scars, anywhere, anytime. My hypothesis is that the decision to scar/regenerate lies in the compositions of specific fibroblast types. To further study this theory I had to resolve a second bottleneck, the current lack of assays that display the full complexity of scarring and regeneration. I have thus developed innovative technological approaches (four novel tools) that allow whole-animal live imaging, tracking and gene modification of fibroblasts.Building on these innovative tools and my expertise in cell lineages as linchpins of this proposal, I aim to: (1) catalogue the repertoires of dermal fibroblast lineages, (2) image their dynamics during scarring/regeneration (3) identify the decision-making genes for scarring/regeneration in actual skin tissues, and finally (4) translate our findings from mouse to human skin. This new notion that specialized fibroblast lineages drive scarring/regeneration, combined with the technology breakthroughs, will greatly advance our current understanding of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Thermal imaging to assess individual physiological state in wild animals' under Horizon 2020.

assistant: **Concept**

Understanding variation in ability to survive and pass on genes (fitness) is central to evolutionary biology and conservation ecology. Fitness differences are largely explained by physiological state, as physiological processes are dynamically adjusted to maximise fitness in response to environmental variation. However, assessing physiological state in wild animals is usually invasive, requiring trapping and handling. As well as raising ethical concerns, such techniques interrupt natural behaviour, can cause bias toward trappable individuals, and may alter subsequent performance. Welfare limits on repeated invasive sampling also restrict tracking of responses over time. Previously, I provided proof of concept for an innovative alternative approach to overcome these issues – non-invasive thermal imaging of body surface temperature. I showed body surface temperature reflects two physiological processes highly relevant to fitness – acute stress and maintenance of energy reserves. But, the mechanisms underlying these relationships remain unclear, calling for rigorous experimental exploration to build the foundations needed for this method to be applied in research and conservation. Hence, the aim of this proposal is to develop thermal imaging as a powerful new tool to advance understanding of the links between individual state and fitness in natural environments. An initial visit to the world leading wild-vertebrate stress lab (Tufts University, US) will be used to perform detailed physiological validations in captivity. Methods established in the US will then be field-trialled in the EU, guided by the expertise of internationally recognised ecophysiologists at the University of Groningen and Max Planck Institute for Ornithology, ensuring in-depth synthesis of results. Comb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Unravelling the function of integrins in the unicellular relatives of Metazoa'.

assistant: **Innovation**

The integrins are a superfamily of the major cell adhesion receptors that bind primarily to extracellular matrix ligands, typically short peptide motifs such as arginine-glycine-aspartate – RGD, but can also bind to cell-surface ligands and soluble ligands. Integrin heterodimers bind and interact with several other proteins forming the integrin-mediated adhesion and two-way signalling complex. This complex consists of alpha-actinin and talin which bind to the cytoplasmic C-terminal tail of the integrin and paxillin and vinculin which bind to talin and alphaactinin. Moreover, the IPP complex composed of ILK, PINCH (particularly interesting Cys-His-rich protein) and parvin acts as a connection between integrins and the actin cytoskeleton.Until very recently integrin-mediated adhesion and signalling machinery was thought to be specific to Metazoa (animals) as they had not been identified in any other group and as their mmost important function – binding to the proteins of the extracellular matrix – is only possible in the metazoans.Recently, integrins and other components of the integrin-mediated adhesion and signalling machinery have been identified in unicellular organisms; such as in the filasterean Capsaspora owczarzaki, a close relative of metazoans and choanoflagellates. However, nothing is known about the function of integrins in the unicellular context.The aim of this project is to investigate the function of integrins and other components of the integrin-mediated adhesion and signalling machinery in the unicellular metazoan relatives. The results will enable us to understand 1) the ancestral function of integrins and 2) how the functions changed during the transition to multicellular metazoans.These findings will significantly improve the general understanding of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Soft Micro Robotics' (SOMBOT) targeting Horizon 2020.

assistant: **Abstract**

The field of Micro and Nano Robotics has made impressive strides over the past decade as researchers have created a variety of small devices capable of locomotion within liquid environments. Robust fabrication techniques have been developed, some devices have been functionalized for potential applications, and therapies are being actively considered. While excitement remains high for this field, we are facing a number of significant challenges that must be addressed head-on if continued progress towards clinical relevance is to be made. This project will address what we consider to be primary roadblocks to be overcome. This includes the development of bioerodable and non-cytotoxic microrobots, development of autonomous devices capable of self-directed targeting, catheter-based delivery of microrobots near the target, tracking and control of swarms of devices in vivo, and the pursuit of clinically relevant therapies. As we consider these advances, it becomes clear that the field of micro and nanorobotics is moving away from hard microfabricated structures and towards soft, polymeric structures capable of shape modification induced by environmental conditions and other “smart” behaviors. Just as the field of robotics witnessed the emergence of “soft robotics” in which soft and deformable materials are used as primary structural components, the field of microrobotics is beginning to experience a move towards “soft microrobots.” Soft microrobots are made of soft, deformable materials capable of sensing and actuation and have the potential to exhibit behavioral response. As we develop more complex soft microrobots, we are poised to realize intelligent microrobots that autonomously respond to their environment to perform more complex tasks.  This project will develop a number
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Equivariant riemann-roch type theorems in arakelov geometry'.

assistant: **Concept**

Research objectives and content Let f be a molphism between algebraic schemes. The theorerms of Grothendieck- and Lefschetz-Riemaml-Roch allow to compute the push-forward morphism induced by f on algelbraic K-groups. The theorem of Grothendieck-Riemann-Roch has been genelalized in two directions. On the one hand, one can consider an equivariant situation where a group scheme G acts on all objects involved. On the other hand, there is an arithmetic Riemann-Roch theorem in the context of Arakelov geometry. The objective of the project is to develop the basic setup of Arakelov geometry and arithmetic K-theory in an equivariant context and to give generalizations of the Lefschetz-Riemann-Roch and the equivariant Grothendieck-Riemann-Roch the- Orems. More concretely, the aim is to consider the following points: ? Define equivariant arithmetic K-groups of arithmetic G-schemes and establish their basic properties (products. A-structure. etc.). ? Define an equivariant determinant of cohomology and equip it with a.Quillen metric. More generally define a push forward morphism on equivariant arith- metic K-groups and establish its basic functorial properties. For example, is there an excess intersection formula? ? Find and prove arithmetic Lefschetz-Riemann-Roch formulas and an equivari- ant arithmetic Grothendieck-Riemann-Roch theorem. Is there a localization theorem for euivariant arithmetic K-groups? It is planned to consider in a first step simple situations like relative curves and projective spaces and to put restrictive conditions on the group schemes. Training content (objective, benefit and expected impact) In the last years. there has been increasing interest in equivariant and arithmetic Riemann-Roch theorems. The project will allow me to enter this very active area of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'UPGRADING OF RESEARCH EQUIPMENT FOR DYNAMIC TESTING OF LARGE SCALE MODELS' (UREDITEME).

assistant: **Innovation**

There is no doubt that that the Institute is the largest and most important RTD centre of the Former Yugoslav Republic of Macedonia in any S&T field. In the 1980s the Institute invested about four million Euros in the development of its dynamic testing laboratories as well as for the education of young scientists in well known centers in Japan, USA and several European universities. Therefore, it is most worthwhile investing in its tradition and know-how and helping upgrade its infrastructure and human potential, to recover and surpass its capacity, level of activity and excellence and international standing. In order to enhance the participation of IZIIS in international cooperation and in the integrated European Research Area, it is necessary to take action now in the direction of reinforcement of the Institute’s RTD capacities. This will have a strong impact on further improvement of the quality of research in the area of seismic risk reduction and protection of structures from other environmental dynamic or technological hazards. It will save human lives and property in future earthquakes and reduce economic losses, producing in the long-term positive economic and social effects. On the other hand, creation of extraordinary working and research conditions, access to hi-tech infrastructures will keep our people at Institute and even engaging young and ambitious researchers from the wider region. Reinforced and upgraded RTD capacities will improve much more our competitiveness in respect to the European and World research centers and also to joint participation with other laboratories from the EU member states in research programmes financed by EU within the frames of FP7 and other calls from EC.