RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Integrated In Silico Models for the Prediction of Human Repeated Dose Toxicity of Cosmetics to Optimise Safety' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The COSMOS project will address the assessment needs of the cosmetics industry by delivering an integrated suite of computational tools to predict the effects of long-term exposure to cosmetic ingredients in humans, thus reducing the need for repeated dose toxicity testing in animals. To achieve this, individual modules comprising: (new) databases, thresholds of toxicological concern (TTC), in silico toxicology (grouping, read-across and QSAR), in vitro data and physiologically-based pharmacokinetic (PBPK) modelling, will be used to construct flexible workflows for assessing toxicity. The COSMOS project will be informed by the needs of industry through active stakeholder engagement, and will utilise innovative technologies from outside the cosmetics area. New databases for TTC and modelling studies will be created by harvesting US FDA legacy data for cosmetics. New and current databases will be combined to advance the state-of-the-art providing a transparent, freely-available public resource. Grouping and read-across will be achieved mechanistically and on the basis of structural similarity. The effective dose-response at the target organ will be estimated from in vitro effects and PBPK models, establishing an alternative (non-animal) basis for risk assessment. All models and Workflows developed will be transparent, fully documented and open access. The partners include world leaders committed to donating software and algorithms to support the open architecture. Data and models will be integratable with existing systems. Workflows will be automated through the  KNIME software.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Recommendations for Reliable Breeder Documents Restoring e-Passport Confidence and Leveraging Extended Border Security'.

assistant: **Objectives**

The project ORIGINS aims to study the security of the extended border and more particularily passport breeder document security. The underlying idea of ORIGINS is to improve the security and therefore to restore the confidence in the application process and issuance of e-passports, by filling the gaps in security of breeder documents. Indeed, while some assurance approaches have been implemented in a few countries, they remain insufficient to provide breeder documents in complete security and trustworthiness at a time when this is increasingly necessary.This project will therefore investigate exhaustively the current state of passport breeder documents requirements and issuing practices in Member States/Associated Countries. The identification of common security gaps will lead to the recommendation of possible solutions to overcome the security weaknesses in breeder documents. The project will provide support for issuance bodies and border control communities. It will also promote the standardisation of breeder documents by creating a dedicated working group at a European level.These objectives will be achieved through the establishment of a strong networking environment between key actors in the sector (passport breeder document and e-passport communities, border control community, ministries, industry, SMEs, universities, NGOs, the European Commission, the European Parliament and the Council, …), exchange and dissemination of good practices between relevant communities, the definition and organisation of joint or common initiatives, meetings, conferences, events and with an appropriate management of the action. Broad communication and dissemination actions will be undertaken throughout the project lifecycle. At the same time, it is expected that ORIGINS’ results will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Determination of evolutionary conserved genes that respond to reduced food intake through mitochondria signaling to affect aging' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The links between diet and lifespan have been revealed 70 years ago but still constitute one of the most mysterious, exciting and extensively studied areas in aging research. In various organisms tested, a restriction of food intake, or DR, can result in lifespan extension up to 50%. In rodents and nonhuman primates, the beneficial effect of DR on longevity is accompanied by reduced incidence of age-related diseases. Thus, as world populations age, understanding how DR impacts animal physiology has far-reaching potentials in term of public health. Recent research has shown that the mitochondrion organelle play an important and evolutionary conserved role in mediating physiologic effects of DR. Our project aims to uncover the molecular changes induced by mitochondria upon DR in C. elegans. We propose to identify genes downstream of mitochondria that affect animal physiology and in particular lifespan upon DR. The nematode C. elegans is an excellent model for this project because of its many powerful genetic and genomic tools. In our first objective, we plan to generate a novel DR model in C. elegans based on its mitochondrial component using chemical and genetics mimics. In our second objective, we propose to identify the gene expression changes specifically induced by mitochondria upon DR. This proposal is likely to reveal new mediators of the cellular adaptations induced by reduced food intake. In addition, our findings will also greatly improve the understanding of mitochondrial signal transduction in controlling whole organism physiology and aging processes. In the future, our research may contribute to therapeutic development of mitochondria-targeted strategies to benefit healthy aging and alleviate age-related diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Co-evolutionary dynamics of viral pathogens  and human antibody response' (CoEvolve), addressing dissemination and exploitation.

assistant: **Impact**

Vertebrates, like ourselves, use adaptive immune cells to protect themselves from pathogens. Predicting mutations of these pathogens, together with the immune response, is essential for the design of vaccines and therapies. CoEvolve will map the co-evolution of immune repertoires and viral populations, to forecast likely properties of future infecting strains and to design interventions that improve immune control.Much effort has been devoted to evolving viral pathogens, but most studies focus either on viral evolution or on immune adaptation in individual hosts. Yet pathogen and host dynamics are coupled: viruses escape from immune recognition, while immune systems adapt to changing viruses. CoEvolve takes an integrative approach: we will study host immune evolution and viral evolution together and on equal footing.We will focus on two viruses, influenza and SARS-CoV-2, that cause severe respiratory diseases. Both viruses evolve rapidly and are transmitted between hosts in acute infections. Influenza has evolved in humans over decades, while SARS-CoV-2 has entered humans more recently and is likely reaching a long-term co-evolutionary state. In both systems, we will track and predict co-evolution on multiple scales: in laboratory experiments, longitudinal human tracking studies, and globally circulating populations.CoEvolve will develop new molecular binding and neutralisation assays for high-throughput tracking of host-pathogen immune interactions and multi-scale inference methods for coevolution. Based on these data and methods, we will • map co-evolutionary landscapes of viral-immune molecular interactions,• build data-driven models of human immunity and co-evolutionary dynamics,• predict viral-immune co-evolution and inform vaccination strategies to optimize immune
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Protein nanocage-scaffolded proteoliposomes: de novo design of a platform for bacterial vaccines' to be submitted under Horizon Europe.

assistant: **Abstract**

Pathogenic bacteria pose significant threats to the global healthcare and the economy. Amid growing concerns over antimicrobial resistance, many healthcare programs have pivoted to vaccine development, while new vaccine platforms are in a high demand for disease control and swift responses in the case of health emergencies. A major type of bacterial immunogen is transmembrane beta-barrel (TMB) proteins, which are found on the outer membrane of Gram-negative bacteria and play key roles in virulence. The native folding and trafficking of TMBs requires specific machineries that do not exist in eukaryotic cell membranes. Consequently, there has been few vaccine platforms for TMB immunogens. To address this need, I aim to construct protein nanocage-scaffolded proteoliposomes (PNC-PL) that can act as highly potent nanoparticle vaccine platforms for TMBs. Such nanomaterial will be developed using two cutting-edge strategies in vaccine formulation: multivalent presentation and immune targeting. Combining my strong background in PNC engineering and my host labs expertise in TMBs and their computation-assisted design, (1) I will multivalently present computationally engineered TMB immunogens on PNCs in a well-controlled manner, resulting in vaccines composed of PNC-PL nanoparticles that mimic the structures of enveloped viruses. (2) I will design transmembrane anchors using computation-assisted methods to host soluble protein ligands that recognize immune cells. The resultant complexes will be subsequently co-presented with TMB immunogens on PNC-PLs for immune targeting, which will further increase the vaccine potency. (3) With my co-host labs rich immunological resources, I will assess immune cell activation induced by the vaccines as a criterion of potency. This novel nanosyste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'AUTOnomous co-operative machines for highly RECONfigurable assembly operations of the future' (AUTORECON) under Seventh Framework.

assistant: **Objectives**

Several industrial sectors today are still using linear sequences of operations where the same manual and automated tasks are repeated in each cycle. This paradigm is efficient when aiming at maximum capacity and considering no breakdowns, but very inefficient in case of line de-saturation. AUTORECON proposes the enablement, development and introduction of a) autonomous, exchangeable and mobile production units which can change tasks and position in the shop floor, b) highly interactive robotic structures c) random production flow and all these, integrated under a common and open architecture. The factory of the future as envisaged by AUTORECON encompasses:- Reconfigurable “Transformers” like tools that enable autonomous assembly equipment which can adapt production process to process disturbances and market variations. The concept integrates novel actuators, end effectors with multiple connection points and advanced sensing capabilities as well as mobile robotic units, fostering efficient multi-variant production.- Intelligent Control & Monitoring systems enabling enhanced performance and high reconfiguration abilities using distributed controls.  AUTORECON unit control will fuse data coming from a peripheral sensing network to allow resource awareness of disturbances. At the line control level a service oriented architecture will enable a) autonomous communication between resources for deciding on adaptation actions and b) the effortless integration of new equipment.A demonstration in the automotive industry will involve the live reconfiguration of an assembly line in the case of a simulated breakdown. The AUTORECON intelligent control will evaluate alternative actions (e.g. use of mobile robotic units etc.) and select the optimal one. A second demonstration in the co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Statistical modelling across price and time scales: a quantitative approach to modern financial regulation' (STAQAMOF), addressing dissemination and exploitation.

assistant: **Impact**

This project aims at providing a new quantitative approach to financial regulation, notably in the context of high frequency trading. The key idea of our method is to build relevant statistical models through price and time scales, connecting the microstructure of financial markets to the long term behavior of prices.  Doing so, we will be able to understand and quantify the macroscopic consequences of regulatory measures modifying the microscopic design of the market. Succeeding in this modelling task will require to address several intricate statistical problems.  In particular new results will be needed in the fields of limit theory for semi-martingales, multifractal processes, rough stochastic differential equations, Hawkes processes and high-dimensional statistics. Hence, through this project, we not only have the hope to provide groundbreaking tools for worldwide regulation of financial markets but, concurrently, to answer important and challenging mathematical problems. In term of analyzing concrete regulatory measures, particular attention will be devoted to the issue of the choice of a proper tick value, that is the minimal price increment allowed on a financial market. Indeed, the tick value is the tool which seems to be favored by most policy makers in order to regulate high frequency trading.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Gated Twisted 2D Superconductor Devices for Quantum Technologies (G-TScon2D)'.

assistant: **Innovation**

G-TScon2D delves into the exciting realm of superconducting (SC) twistronics, where the manipulation of the twist angle between the layers has opened up new avenues for investigating unconventional superconductivity, quantum transport, and emergent phenomena. A significant research gap exists in understanding and harnessing the unique properties of twisted 2D SC materials. G-TScon2D will bridge the scientific gap through a correlated experimental and simulation approach. Its technological advantage lies behind the inherent SC nature of the planned materials, which is expected to lead to higher operating temperature, a critical condition in quantum computing application. The primary objectives of G-TScon2D are to unravel the quantum phenomena and electronic states that arise from stacking and twisting SC layers at precise angles and to explore the SC-to-insulating switching properties by applying vertical gate field. G-TScon2D is a multidisciplinary project in nature and includes the development of 2D SC twisted device fabrication and carrier transport characterisation. G-TScon2D will benefit from close collaboration with a simulation team in the host, which will provide insight into the properties of twisted SC structures and the impact of gate field on those properties. Discoveries in 2D SC materials will accelerate the development of quantum technologies within the EU Quantum and Graphene flagships goal: “Turn Wonder into Action”. G-TScon2D contributes to expanding Europe’s leadership and excellence in this research area, to starting a competitive European industry in Quantum Technologies, and to making Europe a dynamic and attractive region for innovative research, business and investments in this field. This Fellowship will help me to improve my scientific, transfer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Do individuals with intellectual disabilities have an abnormal physiological response to exercise?' under Seventh Framework.

assistant: **Concept**

Individuals with intellectual disabilities (ID) are important consumers of health care, partly due to high prevalence rates of inactivity-related health conditions. So far, adapted physical activity interventions have focused mostly on organizational and behavioural aspects, with disappointing results. In these studies, physiological aspects such as cardiorespiratory capacity or energy cost of activities, were not taken into account or were assumed to be similar to the general population. However, abnormalities in the autonomic response to exercise and higher energy cost of activities have been demonstrated in small and selected samples of the ID population, mostly in people with Down syndrome. The aim of this research proposal is therefore to discover physiological barriers, that influence physical activity and exercise in people with ID. Risks of not knowing about these barriers are fatigue, injury and lack of motivation of people with ID, in a vicious circle leading to loss of functioning and health conditions.During the outgoing phase, I will unravel (abnormalities in) the autonomic cardiorespiratory response of people with ID, using different sympatho-excitatory tasks. During the return phase, I will investigate absolute and relative energy cost (related to cardiorespiratory capacity) of walking in people with ID, and analyze the association with their physical activity levels.By revealing an essential missing link,  this project is expected to make the difference in what has not been achieved so far: a successful long-term approach to prevent health risks and preserve daily functioning skills, by keeping this population as active and fit as possible. The acquired knowledge will greatly benefit the return host.  With this study, I will expand my knowledge and skill
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Bridges Across the Language Divide' (EU-BRIDGE), addressing dissemination and exploitation.

assistant: **Impact**

Today Europe is facing larger and more critical language challenges than ever before. The production of multilingual content now far outpaces our ability to translate it by human effort and we must turn to automatic methods to cope. Thus, effective and innovative alternatives must be provided to Europe's citizens and businesses. High performing machine translation technology can be part of the solution.Recent advances in machine translation (MT) technology now show great promise, as systems can be trained automatically from data and achieve respectable performance, even from speech input. However, MT still has very high maintenance costs, and is unsuited to cope with many of today's digital media's relentlessly changing streams of information, across different topics, styles, and genres.'Bridges Across the Language Divide' (EU-BRIDGE) proposes to advance speech translation to the point where it can deal with the varying input conditions occurring in digital media, and is able to automatically adapt itself to the changing domains.Training data for modern state-of-the-art statistical speech translation models has become a valuable resource that is difficult and expensive to collect in sufficient quantities for all languages and domains of interest. EU-BRIDGE will therefore seek to reduce the cost of data collection and the dependency on collected data.In its research EU-BRIDGE will address European and non-European languages of high importance to the businesses and citizens of Europe, also dealing with the problem of addressing under-resourced languages and their specific peculiarities.EU-BRIDGE will further be working on European infrastructure and network services in order to provide European businesses with a tangible benefit when operating in a multilingual market, e.