RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'FLOw control in RAdial compressor', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The enhancement of an engine operability involves increasing the compressor surge margin which is still an open challenge. The project FLORA (FLOw control in RAdial compressor) is twofold.First, it proposes to achieve a comprehensive understanding of the transient behavior of the radial compressor delivered by the Topic Leader through a precise characterization of the instabilities which develop at various rotation speeds and at different IGV (Inlet Guide Vanes) stagger angles. Detailed experimental investigations are planned providing an improved and time-resolved description of the path to surge.Then, it proposes to apply passive flow control strategies in order to push back the compressor surge line towards low mass flow which will consequently enhance the compressor stability, hence the engine operability. The proposal particularly aims at evaluating the benefits from the boundary layer aspiration in radial geometries in terms of performance (gain in pressure ratio and efficiency) and surge margin. Besides experiments, calculations will help for the understanding of the internal flow structures which develop from stable operating points up to surge.  High-fidelity Large Eddy Simulations (LES) will be used to get an in-depth comprehension of the impact of the flow control on the internal flow.The project FLORA will contribute to the development of stable and efficient radial compressors with extended operating range.


**Keywords:** performance map, instabilities, flow control, radial compressor, inlet guide vanes, experiments, simulations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evolution and function of the Blastocytis mitochondrion-like organelle', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Blastocystis is a unicellular human intestinal parasite, of controversial pathogenicity, that belongs to a diverse eukaryotic phylum called the Stramenopiles. Since Blastocystis is a strict anaerobe, it was thought that it might possess hydrogenosomes, anaerobic ATP-generating organelles related to mitochondria. In contrast to typical hydrogenosomes, Blastocystis has mitochondrion-like organelles (MLOs) with cristae, a transmembrane potential and DNA. Recent work has demonstrated a mitochondrial genome and bioinformatics analyses of expressed sequence tags (ESTs) have identified 115 putative mitochondrial and hydrogenosomal proteins. Amongst these was [FeFe]-hydrogenase, a hydrogenosomal marker protein that was shown to be localized to the MLOs. The organelles are also predicted to have canonical mitochondrial pathways for amino acid metabolism, iron-sulphur (Fe-S) cluster biogenesis and an incomplete tricarboxylic acid cycle. These data suggest that Blastocystis MLOs may be some kind of metabolic intermediate between mitochondria and hydrogenosomes. To test the predicted functions of these MLOs, I will immunolocalize and functionally characterize components of several of its predicted pathways including Fe/S cluster biosynthesis, amino acid metabolism and mitochondrial import. Furthermore, I will purify the Blastocystis MLOs for in vivo assays and proteomic analyses. With these methods I aim to identify the biochemical raison d’être of the mitochondria-like organelle for the parasite. By comparing its pathways with those in other eukaryote lineages, I will determine: (1) the unique biochemical properties of Blastocystis MLO, (2) how Blastocystis MLOs have adapted to an anaerobic and parasitic lifestyle, and (3) how environmental stimuli affect the metabolism of these M
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Locating the Storyteller: Muslim Women’s Auto/Biographical Cinema from the Islamic World' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This pioneering interdisciplinary project identifies a new object of study, Muslim women’s auto/biographical filmmaking, and studies the contextual factors that distinguish it within the field of women’s and feminist cinema. Muslim women academic writers, historians, critics and journalists have been instrumental in establishing a distinctly Muslim feminist identity. Taking on a critical, oppositional stance, they have done this through their literature, life-writings and critiques of Islamic cultural constraints, Sharia laws and religious and cultural discrimination against women in their respective Muslim societies. They have questioned their own political, social and gender histories to redefine the sources of their particular oppressions and formulate strategies for emancipation and equal rights. Additionally, they have turned to the film medium to extend their feminist intent and representations from their particular socio-historical and contextual perspectives. However, research on Muslim women’s contribution to feminist auto/biographical cinema remains a gaping lacuna in film studies. This project aims to fill this gap. Its objectives are:   a) To create a corpus by identifying and categorizing the different modes of autobiographical films produced by Muslim women filmmakers from the Islamic world from the 1980s to date. This implies a broad regional focus and extensive work of data mining and organization of women’s auto/biographical cinemas according to geographical, cultural, and filmic criteria.   b) To develop a contextual scholarly study on works of representative directors to examine Muslim women’s auto/biographical contribution to feminist cinema in the context of their political, personal, historical, social, and institutional conditions. This implies sp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced Data Mining Procedures Applied to Raman Spectroscopy Investigations of Interactions between Drugs and Cells.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Spectro-Metrics focuses on the development and validation of advanced chemometric procedures for investigating drug intake and metabolism in cells using confocal Raman micro Spectroscopy (RS). The project will develop and optimize data mining procedures such as Multivariate Curve Resolution-Alternate Least Squares (MCR-ALS), Supported Vector Machines (SVM) and Science Based Calibration (SBC) for the extraction of biologically relevant information from RS of cells. The applicability of the procedures will be thoroughly validated in vitro including studies on the effect of drug concentration, incubation time and drug distribution within cells. Research activities will include the use of simulated and real spectroscopic data obtained from in vitro studies for investigating the effect of inoculation with the commercial drugs, doxorubicin (DOX) and actinomycin (ACT) in lung cancer cells, as a function of time and dose, as model systems. Upon completion, the project will produce validated methodologies and procedures for resolving Raman spectra which will lead to the elucidation of the modes of drug action and validation of Raman as a preclinical screening technique for drug design and discovery. The knowledge, grant writing skills and publication record acquired during the fellowship will place the Experienced Researcher (ER) in an invaluable position for achieving research independence, becoming a leading expert of chemometric treatment of RS data and eventually becoming a professor in one of the leading European universities in the field of clinical spectroscopy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'ADvanced nanocomposite MAterIals fOr in situ treatment and ultRAsound-mediated management of osteoarthritis' to be submitted under Horizon 2020.

assistant: **Abstract**

Osteoarthritis (OA) is a major burden that affects ~ 40 million of EU citizens, with enormous direct and indirect costs for the European healthcare systems, quantified in ~ 50.4 billion euros per year. This disease involves the degeneration of cartilage and other joint structures and is one of the most common causes of pain and disability in middle-aged and elderly people. ADMAIORA aims in the long-term at increasing the healthy and active lifespan of people affected by OA, by considerably slowing down or even stopping the degeneration process, thus delaying or avoiding surgical interventions for total joint replacement. Within the project time-frame the target is to achieve a 60% reduction of degeneration in OA animal models treated with the ADMAIORA technologies, with respect to control (untreated) ones, after 4 weeks, and a 90% reduction after 3 months. To achieve this ambitious objective the Consortium will evolve and merge technologies that already showed a high potential as experimental proof of concepts (TRL = 3) and will bring them at a preclinical level (TRL = 5). The ADMAIORA Consortium will develop biosynthetic hydrogels embedded with carbon-based nanomaterials, conferring higher mechanical and lubrication properties, and piezoelectric nanoparticles enabling responsivity to remote wireless ultrasound waves. Stem cells derived from autologous adipose tissue, which already demonstrated anti-inflammatory and regenerative properties, will be entrapped in the hydrogels. Materials and cells will be delivered in situ through an innovative handheld 3D bioprinter, embedded in an arthroscopic tool. A custom brace will be designed and equipped with ultrasound probes for both monitoring the joint status and stimulating the implanted piezoelectric nanobiomaterial. A dedic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CONTROLLING AND MEASURING RELATIVISTIC MOTION OF MATTER WITH ULTRAINTENSE STRUCTURED LIGHT' (ExCoMet).

assistant: **Concept**

Femtosecond lasers can now provide intensities such that the light field induces relativistic motion of large ensembles of electrons. The ultimate goal of this Ultra-High Intensity (UHI) Physics is the control of relativistic motion of matter with light, which requires a deep understanding of this extreme regime of laser-matter interaction. Such a control holds the promise of major scientific and societal applications, by providing ultra-compact laser-driven particle accelerators and attosecond X-ray sources. Until now, advances in UHI Physics have relied on a quest for the highest laser intensities, pursued by focusing optimally-compressed laser pulses to their diffraction limit. In contrast, the goal of the ExCoMet project is to establish a new paradigm, by demonstrating the potential of driving UHI laser plasma-interactions with sophisticated structured laser beams–i.e. beams whose amplitude, phase or polarization are shaped in space-time.Based on this new paradigm, we will show that unprecedented experimental insight can be gained on UHI laser-matter interactions. For instance, by using laser fields whose propagation direction rotates on a femtosecond time scale, we will temporally resolve the synchrotron emission of laser-driven relativistic electrons in plasmas, and thus gather direct information on their dynamics. We will also show that such structured laser fields can be exploited to introduce new physics in UHI experiments, and can provide advanced degrees of control that will be essential for future light and particles sources based on these interactions. Using Laguerre-Gauss beams, we will in particular investigate the transfer of orbital angular momentum from UHI lasers to plasmas, and its consequences on the physics and performances of laser-plasma accelera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Codecs based on Auditory Scene Analysis'.

assistant: **Concept**

CASA is designed to train researchers in the development of algorithms, codecs and tools for the 3D audio technology that will be required to deliver very high-quality, object driven sound for immersive and interactive entertainment. Audio technologies and coding methods are as essential to the development of very high quality immersive and interactive 3D media as MP3 (MPEG-1 Audio Layer 3) has been to on-line music and streaming media. Sound is directional: the positioning of sound sources and the acoustics of the space are critical to the experience, impact and sense of presence. Future 3D media and the Internet will need to make it possible to locate and navigate 3D sound as well as vision. Current channel-based approaches to audio coding are unsuitable in several respects and object-based schema such as MPEG-4 AudioBIFS (ABIFS) and Advanced AudioBIFFS (AABIFFS) have so far proved too complex to implement. CASA will research an develop a new 3D audio object approach, based on the application of Auditory Scene Analysis and metadata-based processing to create algorithms, codecs and methods for delivering multi-channel audio that can support 3D interaction. The resulting tools will make it possible for audio engineers to capture and transmit the audio mix as metadata, which can be transmitted with audio assets in such a way as to recreate the audio scene in an optimum way, in any digital environment be it a smart phone, PCs, games console, in-car or home entertainment system, or cinema. The project will be implemented in a programme of work built around a series of exchanges of scientific and technical staff between an academic research centre Dublin Institute of Technology (DIT, Ireland), specialising in audio research and algorithm development; Europe’s leading audio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Systems biology of the AMP-activated protein kinase pathway'.

assistant: **Concept**

Biology is moving from describing phenomena to understanding design principles and dynamic operation of cellular modules, entire cells, and even organisms. The quantitative approach to biological systems is driven by technological advances and close collaboration between different disciplines. Understanding properties of biological systems holds significant promises for drug development, treatment of diseases or improving bioprocesses. In this project, experimental and theoretical studies will be integrated to achieve a better understanding of the dynamic operation of the AMP-activated protein kinase (AMPK) signalling pathway. This pathway plays a central role in monitoring the cellular energy status and trolling energy production and sumption. The ceptional project idea is to generate kinetic mathematical descriptions of pathway activation/deactivation in yeast and mammalian cells. The approach will be highly systematic. A first network model will be generated based on existing data. A standard dataset, including diverse data such as relative and absolute protein, mRNA and metabolite levels and capturing the dynamics of the pathway, will be used to establish kinetic models of yeast and mammalian AMPK. These models will be improved and optimised iteratively in several rounds. A major challenge will be the attempt to use information from the yeast model to fill gaps in the model describing mammalian AMPK. The computational models will support drug development at an SME that is fully integrated into all project activities, If successful, the results will have major payoff to tackle some of the most rapidly advancing diseases in the modern world, obesity and type-2 diabetes. Hence, the project will result in a case study for employing systems biology in drug target identif
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The role of glycoprotein CD36 as a platelet receptor for Streptococci and Staphylococci' (MITISCD36LTA), addressing dissemination and exploitation.

assistant: **Impact**

The binding of microorganisms to human platelets is a central process in the pathogenesis of Infective endocarditis. The deletion of genes encoding platelet adhesins in Staphylococcus aureus and Streptococcus mitis, two leading causes of Infective endocarditis, has been shown to result in a reduction in virulence in animal models of infective endocarditis. While investigating the S. mitis virulence factors that are responsible for the adherence of bacterial cells directly to platelets we identified that bacterial lipoteichoic acid interacts with the platelet membrane receptor CD36. CD36 is a recognised mammalian receptor for bacterial lipoteichoic acid but this is the first time it has been identified as a receptor for the adherence of bacteria to platelets. This adherence phenotype appears to be conserved across other gram positive pathogens as we were also able to demonstrate that S. aureus lipoteichoic acid contributes to the direct attachment of S. aureus bacterial cells to platelets.The purpose of this study is to investigate the molecular interaction of the gram positive pathogens S. mitis and S. aureus and their respective lipoteichoic acids with CD36 and platelets. This will help to identify the role of this interaction in the pathogenesis of infective endocarditis and help define the recognition of bacterial LTA by the immune system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Resisting Language Inequlity/ Resistir la Desigualdad Lingüística' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

ReDes_Ling is an interdisciplinary and inter-sectoral action research project whose goal is to research language inequality and propose innovative strategies to revert its pernicious social effects, promoting sociolinguistic justice and social integration. Building a network of twelve organizations from Europe (Denmark, Greenland, Luxembourg, Spain) and Latin America (Argentina, Colombia, Mexico) that brings together scholars and social actors  (grass-roots indigenous and workers' organizations, cultural institutions, media outlets), ReDes_Ling focuses its action research on three key areas that are fundamental pillars of economic and social prosperity: education, health, and work. To understand and reverse inequalities mediated by social and linguistic issues, ReDes_Ling proposes a three-prong action plan: redistribution of material and symbolic resources, recognition of all languages and speakers, and participation of all communities in social and political life. With this approach, ReDes_Ling will generate four outcomes: (1) a groundbreaking interdisciplinary and inter-sectoral framework to understand and tackle language inequality; (2) a corpus of actions to respond to language inequality that the network will design, implement, and assess; (3) an inventory of interventions to promote an alternative discourse to foster sociolinguistic justice, also designed, implemented, and assessed as part of the action; and (4), a series of materials to intervene in society so that the research and innovation produced by ReDes_Ling reaches our broad immediate social and academic circles, extended populations in the countries where the network operates, and stakeholders and policy makers at the regional, national, and European levels. Our project contributes to the EU's goals of e