RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Custom-designed gene editing of induced epidermal stem cells for gene therapy of genetic diseases of squamous epithelia' (Holo-GT) under Horizon 2020.

assistant: **Objectives**

Holo-GT will define innovative ex vivo gene therapy of dominant genetic skin disease, by using Epidermolysis Bullosa (EB) as a model system. EB is a group of dominantly or recessively inherited, devastating, incurable diseases marked by structural fragility of the integuments. The applicant has shown that combined ex vivo cell and gene therapy can cure the skin of recessive LAMB3-Junctional EB. This lifesaving procedure unveiled that the human epidermis is sustained solely by long-lived stem cells, detected as holoclone-forming cells, which generate transient progenitors referred to as meroclones and paraclones.However, over 50% of EB are dominantly inherited, making gene addition unsuitable. Gene editing does not efficiently correct epidermal stem cells, which define a small proportion of clonogenic keratinocytes and cannot be prospectively isolated.Holo-GT aims at designing a safe and efficacious protocol for dominant forms of EB through:•Molecular characterization of the keratinocyte clonal types and pathways sustaining holoclone-forming cells by single-cell RNA profiling.•Generation of induced holoclone-forming cells (iHolo) by transient expression of specific sets of transcription factors (identified in aim 1) able to reprogram progenitors into holoclone-forming cells.•Development of custom-engineered CRISPR/Cas nucleases, based on selection-based directed evolution or structure-guided mutagenesis, able to fully distinguish wild type and mutant alleles.•Using this newly developed CRISPR/Cas system, gene editing of iHolo prepared from keratinocyte cultures initiated from patients with dominant forms of EB. Holo-GT could tackle not only dominant EBs but also other dominant genetic diseases of the epidermis and other squamous epithelia, as well as recessive forms of E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Circulating tumor cells for tailoring BMP targeted therapies' (CTC4BMP) under Horizon 2020.

assistant: **Objectives**

Gastro-intestinal (GI) cancers, including gastro-esophageal junctional (GEJC), gastric (GC), colorectal (CRC) and pancreatic cancer (PC) are devastating malignancies that annually affect over 2 million persons worldwide and lead to more than 600,000 deaths (Globocan 2012). Given the current trends, the incidence of GI cancer is expected to increase further. Conventional therapies include chemo- and radiation therapy combined with surgery. However, amongst cancer patients, GI cancer patients have one of the poorest outcomes with a 5-year survival ranging from only 60% for CRC to a mere 5% for PCAt the moment, important steps are being taken to implement the highly specific anti-BMP4 low molecular weight antibodies (Dwarfbodies ®; DB, recently developed by us) in the clinic as a novel treatment strategy for gastro-intestinal (GI) cancers. To enable optimal treatment a diagnostic compendium is required. The CTC4BMP project aims to deliver a blood based method for patient stratification to identify patients that will benefit from the BMP4 inhibiting Dwarfbody therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Building biological computers from bacterial populations' (SynBioBrain) targeting Horizon 2020.

assistant: **Abstract**

Biosensors detect compounds using a biological component combined with a physio-chemical detector. Using synthetic biology, we can now engineer bacteria into whole-cell biosensors where sensing, transduction and output occur within the living cell. Applications include the detection of harmful environmental agents, bioprocess monitoring, and detecting medically relevant biomarkers. As we move towards more sophisticated applications, single channel read-out will be replaced with sensors that have multiple inputs and more complex information processing capabilities. Whilst digital logic within a single strain of bacteria can be implemented, consortia offer a powerful alternative, where information is integrated and processed in a distributed fashion. This proposal sets out a research project that will construct biological computers formed from engineered bacterial populations that communicate using quorum sensing molecules. Information from multiple biosensor inputs will be integrated and processed by the biocomputer, the output of which will be spatial patterning. The architecture will be based on cellular automata, which can perform any computation, including logic and temporal logic operations, memory and counting, all of which can be used to distinguish states in complex biological and chemical environments. Our biocomputers will be housed in microfluidic devices using hydrogel structures to create two and three dimensional regular arrangements. As a proof-of-concept, we will develop a biocomputer for the analysis and monitoring of intestinal and microbiota health through stool samples. Sensors for inflammation, pH and short chain fatty acids will be combined into a device that can indicate whether an individual has inflammatory bowel disease or irritable bowel syndro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Empowering the Central and Eastern European Countries to Develop Circular Bioeconomy Strategies and Action Plans' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

CEE2ACT will empower countries in Central Eastern Europe and beyond (Bulgaria, Croatia, Czech Republic, Greece, Hungary, Poland, Romania, Serbia, Slovakia and Slovenia) - CEE2ACT target countries - to develop circular bioeconomy strategies and action plans through knowledge transfer and innovative governance models enabling sustainability and resilience to achieve better informed decision-making processes, societal engagement and innovation, building on the practice of experienced countries serving as role models in this context (Austria, Germany, The Netherlands, Belgium, Spain, Finland, Sweden). Knowledge transfer and inspiration in creative formats that address the motivations, needs and knowledge gaps of each CEE2ACT target country will be realized through the CEE2ACT National Bioeconomy Hubs. A participatory, non-political, bottom-up approach will be applied throughout the project activities, tackling specific knowledge gaps and shortcomings of the top-down conventional approach, building closer interconnections between actors across public institutions, private sector, industry, energy, SMEs, feedstock providers (e.g., waste, side streams, farmers, foresters, fishermen), academia and research, NGOs, CSOs in the target countries. To achieve this, a baseline assessment will be carried out (socio-economic and environmental aspects), stakeholder engagement activities will be implemented ensuring the proper involvement and active participation of all relevant stakeholders. Digital solutions for sustainable governance will be created, exchange of know-how and best practices on technology transfer, building the capacities of the stakeholders to develop bioeconomy strategies. The findings will be synthetized, in an analytical framework, which will result in National-level
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Tracking children in their best interests: electronic monitoring in three European juvenile justice systems' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The implementation of alternatives to deprivation of liberty throughout the juvenile justice procedure has been on the agenda of international children’s rights for about 28 years. The urgent need for alternatives is based on the requirement of the UN Convention on the Rights of Child to use measures that deprive children’s liberty as last resort and for the shortest appropriate period of time. Accordingly, states have to develop suitable alternatives to detaining children for justice purposes. One of the currently popular alternative measures is surveillance of juvenile offenders by using electronic monitoring (EM) devices. EM ensures control through GPS or radio frequency technology, allowing juveniles to remain in or return to the community and maintain their ties with their families and peers. Although these measures seem to be popular among policy makers because of the high level of control, concerns are also raised about their harmful effects, which may be significant in childhood. This research investigates how the application of EM suits the requirements set out by international documents on children’s rights and how national or international policies may be improved towards a better compliance with children’s best interests. The research will be implemented in England and Wales, Hungary and The Netherlands, using a variety of qualitative (interviews, focus groups) and quantitative (survey) methods to investigate the research questions. The project will generate unique knowledge on multiple aspects of using EM measures in juvenile justice, which will, for the first time, develop understanding at a European level about EM from the perspective of children. It will demonstrate a unique, children’s rights approach and involve different actors of the system, juvenile
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Immunity in Ecology and Evolution: 'Hidden' costs of disease, immune function and their consequences for Darwinian fitness' (EcoImmuneCosts), addressing dissemination and exploitation.

assistant: **Impact**

Eco-immunology targets one of the great challenges in biology and medicine - how the immune system has evolved to optimize protection and minimize immunopathology (incl. autoimmune) costs. A primary target of my proposal is to study low-virulent pathogens causing mild infections, which for long have been considered harmless. Recent research suggests that this notion is false and that seemingly harmless pathogens entail delayed (‘hidden’) fitness costs. However, the mechanisms mediating these costs are still unknown. I will experimentally test if accelerated telomere degradation is a causative mechanism through which small immune costs can accumulate and be translated into senescence and reduced Darwinian fitness. Another key target is immune costs, which may be ‘hidden’ because of sexually antagonistic effects, and I will study how this may affect immune gene variation, immune costs and Darwinian fitness. These aspects are central for advancing our understanding of the evolution of disease resistance and immune function, incl. immune over-reactions (autoimmunity).My project exploits a comprehensive 32-year study of great reed warblers to analyze selection patterns in the wild (Fig. 1a), and uses established captive songbird set-ups to conduct carefully designed experiments. The exceptional quality of the long-term data set, together with cutting-edge techniques to measure and manipulate parasite infection, telomere length, oxidative stress and immune gene diversity, provides exciting opportunities to conduct research that previously was unfeasible, pushing the rapidly growing field of eco-immunology (Fig. 1b) to new frontiers. The work integrates theory and methods of evolutionary ecology, immunology and molecular biology, and has broad significance including for e.g. e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Molecular characterisation of the interaction in compatible and non compatible populus/p. involutus ectomycorrhizae'.

assistant: **Innovation**

We want to investigate, what triggers the defence reaction of the plant during the early phase of the mycorrhizal interaction leading to mutuality or a parasitic interaction. We will focus on genes, differently expressed in compatible or non-compatible plant fungus systems (populous / P. involutes) responsible for the different plant response.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sacred Words, Secular Policies: Cross-Cultural Analysis of Metaphor and Discursive Strategies of Gender Representation in Arabic-Italian Discourses' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

DECODE – Sacred Words, Secular Policies investigates how Arabic- and Italian-language public and institutional discourses—especially those drawing on Islamic and Catholic references—use metaphor and other discursive strategies to frame gender and shape (or clash with) gender-equality policies. Pairing parallel institutional voices (e.g., Al-Azhar/Vatican) and shared value vocabularies (dignity, honor, protection), the project fills a cross-cultural research gap at the intersection of language, religion, and gender.Methodologically, DECODE builds a 500,000-word bilingual corpus (2015–2025) and applies an integrated CMT (Conceptual Metaphor Theory) – MIPVU (Metaphor Identification Procedure, VU University) – CDA (Critical Discourse Analysis) pipeline with rigorous inter-annotator reliability, producing an open, FAIR-compliant dataset, a transferable comparative framework, and a taxonomy of gendered metaphors. Preliminary patterns suggest that “dignity” is framed in Arabic discourse as a “precious object requiring protection” versus an “inherent right requiring recognition” in Italian discourse—differences with direct policy implications.Hosted by Ca’ Foscari University (return phase) with an outgoing phase at the University of Toronto, the fellowship couples linguistic analysis with religious-studies expertise to ensure cultural-theological accuracy. Expected outcomes include peer-reviewed publications, an annotated bilingual corpus, open methods and code, and a policy brief disseminated to European and national equality bodies, advancing evidence-based, culturally sensitive gender communication aligned with EU open-science and impact priorities.


**Keywords:** Arabic–Italian comparison; Cross-cultural discourse analysis; Metaphor Theory; Critical Discourse Analysis; Gen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Multiculturalism in the work of Aldo and Hannie van Eyck. Rethinking universalist notions in architecture.'.

assistant: **Objectives**

Today, we live immersed in a new globalized universalism, an increasingly homogeneous planet where architecture remains dominated by mass media, hindering renewal. However, in the aftermath of WWII, the Dutch architects Aldo and Hannie van Eyck already proposed a profound rethinking of the eurocentrism of his time. In their work, one can observe a hybrid of universalist and exoticist attitudes, looking for both continuity and renewal of the pre-war avant-garde and for critique on capitalist and nationalist ideologies of his time. This research aims to scrutinize the blending of non-western and modern art in the Van Eycks’ designs in a holistic way where space, inhabitants, political ideas and ways of living merge to shape a multiculturalist notion of society and architecture. There have been earlier attempts to study Van Eyck’s relation with the vernacular by Strauven (1998) and recently Jaschke (2011) and Rodríguez (2016), but they focused on form relations or lacked the full archival sources to tackle the issue. Recent research (2018) has uncovered an enormous amount of information that will be used to go beyond state-of-the-art. The multidisciplinary nature of the project is strong, since it will develop an innovative qualitative approach to the architect’s oeuvre from his private house, an Anthropology of Architecture, using his full ethnographical art collection, books, travel pictures and conference slides as an entry to document and unpack the ways domesticity, global travels and art collecting intersect and sustain a non-universal view from which architecture was re-conceptualised. Proper measures will be taken to integrate the research into different areas of expertise. The results would constitute the first critical inquiry on the influence of the ""ethnograph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'High Accuracy Navigation under Scintillation Conditions' to be submitted under Horizon 2020.

assistant: **Abstract**

The main goal of NAVSCIN is to develop an improved strategy to mitigate scintillation –a particular type of space weather perturbation– tailored for satellite-based navigation techniques, in close collaboration with users and manufacturers of these technologies. Indeed, once the scintillation effect is correctly detected and mitigated, the availability and accuracy of the five billion devices using Global Navigation Satellite Systems around the world, will dramatically improve. The project implements a set of coordinated actions among its different partners that maximize international collaboration between universities, research centres and industry, in different European and Asian countries: First, NAVSCIN will improve the understanding regarding the physical processes resulting in the formation of scintillation, and consequently to identify the drivers in the interplanetary medium, the magnetosphere and the atmosphere. Second, the impact of scintillation on space-based navigation users will be characterised: mainly Ground and Aircraft Based Augmentation Systems (SBAS, GBAS) and high-accuracy navigation techniques (Precise Point Positioning). Third, a set of NAVSCIN algorithms will be developed suitable to support, for the first time, the real-time identification, correction and/or mitigation of scintillation in GNSS receivers. Finally, NAVSCIN will work systematically with potential users to assess the functionality, reliability and efficiency of the proposed solution, paving the way to its systematic exploitation and to its sustainable operation. Overall, the European competitiveness will be potentiated throughout the project with the exploitation of the research results, ultimately giving high-level EU employment and maintaining the European status quo of high‐level
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Adapting fishways to hydrological and climatic uncertainty'.

assistant: **Objectives**

Current society needs a large volume of fresh water to keep its present lifestyle. This has led to the massive installation of barriers in rivers, causing fragmentation of habitats and ecological alteration of freshwater systems. Fragmentation specially affects fish, as they require different environments to complete their life cycles. Stepped fishways are the most extended solution to ensure fish movements. Unfortunately, their efficiency is sensitive to the equilibrium between biological and hydraulic aspects, which, is often far from acceptable. The natural variability of rivers modifies the hydraulic conditions within fishways, affecting the biological responses and their principal objective: allow the free movement of fish. This research project aims to (1) assess the effect of hydrological variability in stepped fishways and for this (2) to develop a technological and methodological framework to monitor fishways performance in real time which combines fish biology, hydraulics and sensor networks. This will allow creating a new generation of smart fishways capable of self-deciding their optimal configuration when faced to hydrological uncertainty.The study of the effect of variability will allow to adapt and propose specific solutions to some of the challenges that need to be faced the coming years, such us accomplish the requirements or Water Framework (2000/60/EC), Habitats (1992/43/EEC) or Renewable Energy Directive (2009/28/EC), and will help to define solutions and actuation plans for the possible modifications in the water cycle produced by the climatic change, in line with EU Adaptation Strategy.


**Keywords:** FISHWAYS, HYDROLOGICAL VARIABILITY