RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'CoaBC from the Coenzyme A pathway of Mycobacterium tuberculosis as an antimicrobial drug target' in the context of a Horizon 2020 call.

assistant: **Objectives**

The increasing prevalence of drug-resistant microorganisms worldwide and the shortage of novel antimicrobial chemotherapeutics in the pipeline places our capacity to treat infectious diseases under serious threat. Antimicrobial chemotherapies with novel modes of action are desperately needed. However, the development of such therapies is a formidable task associated with a high failure rate. This has been partly attributed to the limited diversity of high-throughput screening libraries and difficulties converting potent inhibitors of targets into cell-active leads. We intend to use a novel, unified and efficient approach to target, in multiple pathogenic microorganisms, the conserved biosynthesis pathway of Coenzyme A (CoA), an essential enzyme cofactor. Using powerful “fragment-based” approaches, pioneered in Cambridge, we have developed a series of highly potent inhibitors of the most vulnerable enzyme target in the bacterial CoA biosynthesis pathway of Mycobacterium tuberculosis (Mtb), Mtb CoaBC, a target which has recently been validated in experiments using conditional knockdown mutants in CoA pathway genes. We will focus our initial efforts in confirming that tuberculosis (TB) can be combatted with small molecule CoaBC inhibitors. In addition, we propose to assess the cross-species activity of these inhibitors on a panel of other pathogenic microorganisms, leveraging this research and potentially generating leads for antibiotics against these other pathogens.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Electrically Controlled Protein Conformation on 3D Tissue Scaffolds'.

assistant: **Innovation**

ProtEprobe takes advantage of the recent cutting edge developments in protein conformation control at the Malliaras group and high sensitive protein sensing using high sensitivity factor triangular silver nanoplates by the fellow. Misfolding of a protein occurs when it becomes trapped in a local potential energy minimum where the conformation differs from the native-state structure. External electric fields have been demonstrated to distinctly alter protein secondary structures. Proteins associated with protein misfolding diseases, incuding neurodegenerative diseases such as Alzheimer's, undergo conformational changes such as the transformation of largely random coiled or α-helix structures to the highly ordered β-structures found in protein fibrils. Amyloid fibrils formed from peptide Amyloid beta (Aβ), are a major component of amyloid plaques in the brains of Alzheimer’s patients. The ProtEprobe technique will use electrical potential gradients to stimulate and control the conformation transitions of proteins including the cell adhesion protein Fibronectin and Aβ on 3D electrospun conductive polymer tissue scaffolds. The high sensitive spectral response of the nanoplate monitors will be used to analyse protein conformational transitions and observe the progression of Aβ fibril formation. Investigations will be carried out to ascertain the impact of the presence of an electric field and the capacity to tune the strength in order to enable improved understanding and selection of protein conformations on tissue scaffolds, towards enhancing cell surface interactions, healing of misfolding and facilitating the restoration of the structure and function of diseased tissues. In a paradigm step towards imparting a new dimension to tissue regeneration, ProtEprobe will develop 3
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mechanobiology of the cellular circadian clock' in the context of a Horizon 2020 call.

assistant: **Objectives**

The circadian clock is the biological mechanism that directs the physiological ~24 hour oscillations that most living organisms undergo to anticipate the daily pattern of light. In mammals, that rhythmicity results from a highly conserved genetic circuit –based on transcriptional and post-transcriptional regulation– that works synchronously at a cellular level and differs among tissues. Around the 10% of the mammalian proteins, including essential components of the cell cycle and differentiation pathways have been categorised as circadian. Thus, a clock dysregulation may have pathological consequences, which is the case in some types of cancer. Although synchronous circadian cells share a common mechanical microenvironment, the contribution of mechanics to the clock maintenance has never been addressed. To fill this gap, the aim of this project is to unravel a) the impact of the mechanical microenvironment on the cellular clock, b) the influence of circadian oscillations on the mechanical behaviour of the cells and c), the interplay between mechanics and the clock during stem cell differentiation. To achieve these goals, we will combine state-of-the-art technologies in cell mechanics, molecular biology, imaging, and computational modelling. As model system we will use entrained MCF-10a and PHK stem cells. By subjecting them to a range of extracellular matrix rigidities, we will measure the influence of mechanics on the circadian expression of core clock, cytoskeleton and differentiation genes. We will then use traction force microscopy to study the rhythmicity of cell mechanics and, through computational tools, we will link gene expression patterns and force oscillatory behaviour in order to elucidate the molecular basis of the ‘biomechanical clock’.This interdisciplina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Constructed wetland to produce high-quality drinking water free from nitrates' (ZIRONITRO).

assistant: **Concept**

Three out of four people in EU drink water from groundwater subjected to severe nitrate contamination by fertilizers and sanitary products used in intensive agriculture & farming. High levels of nitrates in drinking water put human health at risk and have been reported to threaten 26% of EU biodiversity. Current technologies do not meet the needs of small water suppliers, who must face costs derived from high energy consumption (3-7 kWh/m3), poor nitrate selectivity, residual streams and by-products, and continuous costly maintenance. 33% of suppliers in Europe are not compliant with quality standards, particularly nitrate levels. ZIRONITRO is the result of 8 years of research and development by Ofra Aqua Plants, an Israeli company with over 25 years’ experience in bioengineering and phytoremediation. Based on the concept of using nature to cleanse nature, ZIRONITRO is a constructed wetland to biologically treat groundwater by removing nitrates to obtain high-quality drinking water (98% removal), at 84% lower cost than current. ZIRONITRO’s innovation resides in the system’s nitrate removal specificity, with a design that allows low-cost operation and maintenance, along with very high rates of nitrate breakdown by bacteria. The key factor is the selection of the best combination of both bacteria and plants, along with the optimal proportion of methanol as carbon source. The particular environment we have generated inside our ponds reduces hydraulic retention time by 90% and uses 100 times less ethanol than current constructed wetlands. Indeed, we do not use synthetic chemicals, energy input needed is negligible, and neither residuals nor wastewater are generated, so it has no negative impact on the environment. On the contrary, it contributes to both biodiversity conserv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dynamic resource Scheduling in Massive MIMO based NOMA with RF imperfections and Energy Harvesting for 6G networks' (YAHYA-6G).

assistant: **Concept**

YAHYA-6G aims to propose new signal processing solutions doped with machine-learning. We will focus on the detectionand compensation of RF imperfections in mMIMO (massive Multiple input Multiple output) based NOMA (Non-orthogonal multipleaccess) pair . In other hand, YAHYA-6G target is to minimize the long-term power consumption based on the stochastic optimization theory for mMIMO-NOMA IoT networks with EH (Energy Harvesting) in presence of RF imperfections. Thus the objectives of the YAHYA-6G project are:1- Identify major RF imperfections that may occur in a multi-access / multi-antenna broadband system.2- Propose new solutions to optimize the energy efficiency at the RF transmitters. This solution will focus on the power amplifier that represents 60 at 70% of the energy consumed in an RF transmitter.3- Analyze the impact of these RF imperfections on mobile radio systems exploiting NOMA  technologies.4- Propose a Deep Learning online learning process to detect the NOMA channel characteristics and compensate the effect of HPA nonlinearity. A joint detection of the NOMA interference and HPA (High Power Amplifier) nonlinearity will be studiedin mMIMO-NOMA system.5- Resolve a non convex based problem coping with the expected 6G requirements, with a particular focus on optimal resource scheduling and computation capacity allocation and reducing energy consumption of wireless devices, through a set of new algorithms .6- Realize a demonstrator based on the SDR (Software Defined Radio) USRP cards on which some algorithms developed inthe project will be implemented.


**Keywords:** Massive MIMO, EH, NOMA, RF imperfections
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Approaches to control multi-resistant enterococci: studies on molecular ecology, horizontal gene transfer, fitness and prevention'.

assistant: **Objectives**

Vancomycin-reistant enterococci (VRE) have become the paradigm of the post-antibiotic era. Nosocomial VRE-infections are rising in all European countries, with proportions >10% among enterococcal bloodstream infections in 5 countries in 2004. From a microbial perspective, emergence of VRE represents a dual-edged sword: they are amongst the most resistant opportunistic nosocomial pathogens with an increasing impact on patients' health care. Moreover, and maybe even more important, their unprecedented capacity of genetic exchange make them perfect hubs for resistance genes facilitating horizontal gene transfer amongst bacterial species. Genetic population analyses of Enterococcus faecium revealed the presence of a High-Risk Enterococcal Clonal Complex (HiRECC) resistant to multiple antibiotics and responsible for the vast majority of nosocomial VRE infections and hospital outbreaks worldwide. In this proposal, the evolutionary development of HiRECC in E. faecium and E. faecalis will be further unraveled and combined with new knowledge on intra- and inter-species gene transfer (including antibiotic resistance genes) and biological fitness costs of hospital adaptation. This will improve our understanding on the ecological abundance of HiRECC in hospitals. Based on this we will develop novel strategies to control spread of HiRECC through modulation of gut colonization by 1) probiotics, specifically selected to out compete HiRECC and 2) vaccination with Lactococcus lactis particles carrying HiRECC specific antigens. In addition, a novel therapeutic approach will be explored by identifying targets of HiRECC for passive immunization with human monoclonal antibodies.In contrast to MRSA, widespread nosocomial endemicity of VRE has not yet been established in European hospitals an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Artificial Intelligence for optimisation of Fuel Injection Equipment suitable for carbon-neutral synthetic fuels', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Current EU policies mandate the gradual disengagement of the transport sector from fossil fuels. In order for such a transition to become a reality, hydrogen-derived carbon-neutral synthetic fuels produced using renewable energy sources (e-fuels), have overall less life-cycle CO2 footprint than their counterpart electric vehicles while they are suitable for use over the wide range of combustion engines. However, today’s fuel spray experimental methods are compromised by the long time needed for the characterisation of the effect of new fuel molecules; similarly, relevant predictive models that can address in detail the effect of the wide range of fuel chemical composition at time scales relevant to industry are not available. The main objective of the proposed MSCA fellowship is the development of a data-driven deep learning (DL) Artificial Intelligence (AI) algorithm able to predict the spatially and temporally resolved spray structure, as well as critical air / fuel mixture parameters for engine design. Training of the AI model will be based on the largest publicly available experimental database for fuel sprays of the Engine Combustion Network; this covers a wide range of injector configurations, air thermodynamic conditions and liquid fuels. The training matrix of the AI algorithm will be complemented by relevant computational fluid dynamics simulations for operating conditions and fuel composition for which experimentation is not possible. For this purpose, a state-of-the-art CFD model of the compressible Navier-Stokes and energy conservation equations employing elaborate real-fuel thermodynamic closures based on the PC-SAFT equation of state will be employed. The project innovative nature spans across diverse research aspects with emphasis on renewable alternative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Space-time visualization of microelectronic chip operation with femtosecond electron microscopy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Progress in modern information processing relies on the combination of a few-nanometer structures with ever-increasing signal speeds approaching the terahertz (THz) level and beyond. However, the design of such devices is currently restricted by our inability to see and measure the underlying charge carrier dynamics at sufficient resolution in time and space. This proposal aims at solving this problem by combining femtosecond laser technology with electron microscopy for achieving sub-nanometer and multi-THz space-time resolution of electromagnetic fields and charge motion in future microelectronic devices. It relies on the recently demonstrated technique of electron pulse compression down to femtoseconds by means of optical radiation. Electron pulses can capture the electric fields in structures as small as atoms at an instant of time. While conventional electron microscopy is the main tool allowing to see modern nanometer-sized electronic components, it can only sense the structure of devices and not how they operate dynamically. In contrast, femtosecond electron microscopy allows to resolve THz dynamics. Here, in order to drive microelectronic components at THz frequencies, laser-generated THz pulses will be used. Furthermore, a variation of scanning nanotip microscopy will be added providing ultrafine spatial resolution. In combination, this will allow to visualize charge motion and electric fields in microelectronic devices in real-time at with unprecedented space-time resolution. This investigation will critically expand our fundamental knowledge of electron transport at extremely high frequencies, which is necessary for designing future microelectronic devices. Furthermore, it will introduce a disruptive diagnostic solution for industry to see their current and f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of Photochromic Ligands for Selectively Expressed Glutamate Receptors' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

As life expectancies across the world continue to increase, the number of people suffering from a degenerative neurological disorder such as Parkinson’s disease and Alzheimer’s disease also rapidly increases. This is a significant problem (particularly in the developed world), with sufferers regularly experiencing a poor quality of life which often leaves them requiring costly round-the-clock care. Current pharmaceuticals have had some success in treating specific neurological disorders, but their effects are significantly limited as they generally only slow the progression of the disease. Consequently, there is a significant need for new and innovative methods to treat these debilitating neurological conditions. Researchers have established that some neurological disorders are caused by the break-down of neural networks in the brain. This has since been linked to the malfunction of glutamate receptors (GluRs) found in the cell membranes of neurons. In this Fellowship, we propose that new families of photochromic ligands (PCLs) that selectively and reversibly control GluRs using light, could be used to 'reactivate' unresponsive neural networks in the brain, allowing for the development of new and pioneering treatments for neurological disorders. To accomplish this we will develop new PCLs that are 'turned-on' by low energy 'red-shifted' light and then are rapidly 'turned-off' in the dark. This will significantly advance the current state of the art PCLs which are 'turned-on' in the dark, making them unsuitable for therapeutic applications. The new PCLs will target GluRs that are selectively expressed in particular cell types in the brain that are linked with the onset of degenerative neurological diseases. This will allow us to extensively study the role these GluRs pla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Next Europractice eXtended Technologies and Services: “The access point for the future generation of electronic components and systems”' under Horizon 2020.

assistant: **Concept**

The mission statement of NEXTS is to provide the European industry and academia with a platform to develop smart integrated systems, from advanced prototype design to volume production. The latter will be achieved by providing easy and affordable access to a wide range of fabrication technologies and tools complemented with training and support to the customer in all critical steps which are needed. NEXTS will act as a true one-stop shop for technologies enabling fully integrated systems and providing direct routes for industrial up-scaling of those systems and consequently it will sustain and grow jobs in Europe in the areas of design and fabrication of microelectronic component and systems.The partners of the NEXTS proposal have already a vast experience and strong position in providing access to microelectronic technologies. Its predecessor EUROPRACTICE has supported the European academic sector with CAD tools and IC prototyping for over 25 years, and its partners have already supported SMEs with MPW and small volume services for over 15 years. The new consortium has been extended with CMP (Circuits Multi Projects) and TYNDALL who will provide additional access to foundry services and more importantly to system integration capabilities.NEXTS will ensure that the European industry grows the captured value from the development, fabrication and deployment of electronic smart systems and remains a global leader. As a value chain aggregator, NEXTS aims to close the gap between the supply- and demand- side for electronic smart systems in virtually all applications domains. Therefore, it provides maximum transformative impact to all sides of the value chain.


**Keywords:** Smart system integration,  electronic components and system,  CAD tools,  MPW prototyping service,  S