RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Minimally invasive transcatheter system for tricuspid heart valve replacement', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

TRiCares is a medical technology company with the mission to develop and commercialize innovative minimally invasive (transcatheter) solutions replacing high-risk open-heart surgeries for treatment of heart valve diseases. Heart valve diseases are among the most serious cardiac complications affecting >12.7 million patients in Europe. Cardiac surgeons are urgently seeking for a low-risk minimally invasive solution to treat annually >300,000 patients with tricuspid heart valve disease, who are currently simply dying because of having no relevant therapeutic option. TRiCares has uniquely addressed technological challenges associated with tricuspid heart valve disease treatment- the company has developed the first-of-its-kind medical device for tricuspid heart valve replacement (TRICARIX) based on a proprietary dual-stent prosthesis platform.The product addresses a fast-growing transcatheter heart valve replacement/repair market, that is driven by the increasing demand to treat heart valve diseases in the aging population. As no such solution is available for tricuspid valve, introduction of the TRICARIX will create a novel market segment with estimated total market potential of €1 billion in Europe only. The company’s strategy has been built along the regulatory route to obtain CE-marking for the TRICARIX medical device in 2021. TRiCares is led by experienced entrepreneur and experts with successful track record of bringing medical devices to market, including the first European transcatheter aortic valve replacement system in 2012. TRiCares seeks SMEInstr funding to reach the critical First-In-Man study milestone (total costs-of the project €4.3 million) that will greatly facilitate follow-up capital investments to finance the final large-scale efficacy/safety clinical s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Phase Contrast STEM for Cryo-EM' (CryoSTEM) under Horizon Europe.

assistant: **Objectives**

Cryo-electron microscopy has revolutionized the field of structural biology, primarily for macromolecular structure but also for cells and tissue sections—achieving resolutions at the limit of physical optics. While wide-field transmission EM (TEM) with phase contrast by defocus is the most commonly used modality in biology, the alternative, scanning transmission EM (STEM), has emerged as the mode of choice for atomic resolution in materials science. Seeking to endow biology with the benefits of STEM, our lab established STEM for cryo-tomography of biological cells and demonstrated its advantages for thick specimens and compositional contrast. We now seek to extend cryo-STEM to high-resolution, with an emphasis on tomography, by means of coherent detection (Obj1). This will be achieved by the method of integrated differential phase contrast (iDPC) using a segmented detector, from which we obtain simultaneously phase and depth contrast in a single scan. The major expected benefits are: 1) minimization of image aberration, especially defocus with its associated complications for image interpretation, 2) reduction of beam-induced radiation damage by means of flexible scan and sampling patterns, and 3) improved reconstruction for tomography based on tailored data acquisition. We will validate the new methods for single particle analysis on standard macromolecular substrates and compare them to current state-of-the-art methods. Further, we will apply the new developments in 3D imaging to explore novel large-scale structures in chromatin we observed recently by whole-cell cryo-STEM tomography using current, low-resolution methods (Obj2). Labelling with halogenated nucleotides will reveal sites of active transcription or DNA synthesis. The proposed approaches’ expected broad a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Trees to mitigate effects of shocks on food security' to be submitted under Horizon Europe.

assistant: **Abstract**

Climate change exacerbates the frequency and magnitude of disasters (e.g., floods, droughts, cyclones). These shocks are threatening food security, with especially severe effects on the poorest and most vulnerable households. This is worrisome as two billion people already suffer from malnutrition, leading to a range of negative health outcomes. Exploring pathways to support resilience and adaptation to such disasters is critical to mitigate negative impacts on the food security of affected households. Trees inside and outside of forests offer a promising, yet overlooked avenue to increase household resilience and buffer negative impacts of climate-related disasters and other types of shocks. Recent research has established that forests could buffer the impacts of climate-related disasters on household food security. Yet, these studies suffer from lack of pre- and post-disaster data, preventing causal explanations. There is no broad-scale study that uses pre-and post-disaster household data to quantify the extent to which trees inside and outside of forests mitigate the effects of climate-related disasters on food security, across different ecosystems and geographies. Studies have also not yet been able to account for compound effects where climate-related disasters occur simultaneously with other types of shocks, such as conflicts and institutional upheavals. Finally, existing research has been unable to tease apart mechanisms that explain how proximity of forests buffers climate-related disasters. TREESHOCK has the ambitious objective to bring together fields that currently mostly operate in isolation, including climate change adaptation, humanitarian aid, and biodiversity conservation. The project will provide generalizable evidence to inform where climate adaptation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Satellite Data Acquisition in the Blink of an Eye' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

It is widely known that key information used in many industries such as meteorology, logistics, navigation, oil and gas, agriculture, ecology and others, comes from space, via Earth observation (EO) satellites. Having this data in a short time frame is becoming essential. Existing ground segment solutions are heavily based on hardware. They are not following technology advances like space hardware do which causes a bottleneck in EO data acquisition: required volume of data is not available quickly or with sufficient value!  The objective of this proposal is to provide an innovative, completely software-based data acquisition solution for EO market – Blink, disruptive enough to compete with existing oligopoly in this market segment. The EO market is very interesting as it is being boosted by skyrocketing growth of start-ups in NewSpace industry like SpaceX, OneWeb and Planet, to name a few, and increasing trend of moving from thick hardware solutions towards flexible and dynamic software solutions as well as moving satellite ground systems and services in the cloud environment. The expected project outcome is a Blink device, a software-based solution for EO ground stations which will enable assembling a full performant ground station at a fraction of time and cost that are usual at a time being. This will bring benefit not just to growing segment of start-up companies, but also to big governmental missions worldwide, including Copernicus – the EU flagship mission for Earth observation. Humanitarian missions will also benefit from Blink. Construction of a larger number of ground stations and a faster GS deployment will significantly reduce time to get satellite images of disaster-struck areas. Therefore, rescue teams will be able to act faster, and hence save thousands of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Brain barriers training'.

assistant: **Innovation**

The brain barriers function to protect the central nervous system (CNS) from neurotoxic compounds. By the same traits they unfortunately block delivery of drugs to the CNS thus hindering proper diagnosis and effective treatment of neurological disorders including Alzheimer’s disease and multiple sclerosis. The unusual complexity of the brain barriers has severely hampered progress in the market of CNS targeting therapeutics. BtRAIN bridges this gap by creating particular knowledge on vertebrate brain barrier signature genes and their specific roles in regulating brain barrier function in development, health, ageing and disease.  Brain barrier signature genes will be identified by combining cross-species and cross-system brain barrier transcriptome analysis with dedicated bioinformatics. These data will be made available for brain barrier datamining in the userfriendly online platform BBBHub. Within BtRAIN, the side-by-side comparison of a unique and broad armamentarium of different vertebrate in vitro and in vivo brain barrier models will allow to develop and validate particular in vitro brain barrier models that are suited to reliably predict brain barrier function in vivo. Combined with an accompanying in depth analysis of the pathological alterations of the brain barriers during neurological disorders BtRAIN will create unique knowledge to overcome the unmet need for the development of diagnostic and therapeutic tools able to breach the brain barriers. In BtRAIN 12 academic, 6 non-academic partners and 1 European network will jointly train young researchers at unique interfaces of brain barrier research, bioinformatics, business development and science communication for an international research or entrepreneur career. To create this expert pool is the motivation for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European E&M 450mm Pilotline Readiness' in the context of a Seventh Framework call.

assistant: **Objectives**

Aim of the EEM450PR project is to continue the engagement of the European semiconductor equipment and materials industry in the 450mm wafer size transition that started with the ENIAC JU EEMI450 initiative. It will also bring about the start of a vision to place an equipment development pilot line in the imec facility in Leuven. This will provide Europe with a complementary activity for 450mm equipment, and later on sub 10nm process development. The consortium comprises 34 members (from 10 different European countries); 11 are SMEs and 4 are research institutes.  The main objective of the work on lithography is the proof of concept at test bench level of 450 mm critical wafer stage technology to get prepared for 450 mm early lithography prototype realization in a subsequent phase.The work on materials is the follow-up activity of the EEMI450 project to reach the next level of 450mm wafer quality. To be able to produce these wafers with the required capabilities new sophisticated equipment for the Chemical Mechanical Polishing process step as well as very advanced equipment for final cleaning procedures will be developed and will be integrated in a 450mm wafer line.Next to technology development also a 450mm equipment development pilot line facility will be prepared by developing state-of-the-art facilities readiness, including stringent energy and contamination considerations taking recent ISMI Guidelines, Semi Standards and ITRS requirements and activities into account.Furthermore, work will be done on the development of pilotline-ready equipment and modules, and further optimization of prototypes, concerning front-end (wafer based) semiconductor processing. The companies that were involved in the ENIAC EEMI450 project will use the results obtained therein for further
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A new paradigm to re-engineering printed composites'.

assistant: **Innovation**

Additive manufacturing and Automated Fibre Placement (AFP) processes brought to the emergence of a new class of fibre-reinforced materials; namely, the Variable Angle Tow (VAT) composites. AFP machines allow the fibres to be relaxed along curvilinear paths within the lamina, thus implying a point-wise variation of the material properties. In theory, the designer can conceive VAT structures with unexplored capabilities and tailor materials with optimized stiffness-to-weight ratios. In practise, steering brittle fibres, generally made of glass or carbon, is not trivial. Printing must be performed at the right combination of temperature, velocity, curvature radii and pressure to preserve the integrity of fibres. The lack of information on how the effect of these parameters propagates through the scales, from fibres to the final structure, represents the missing piece in the puzzle of VAT composites, which today are either costly or difficult to design because affected by unpredictable failure mechanisms and unwanted defects (gaps, overlaps, and fibre kinking).This proposal is for an exploratory study into a radical new approach to the problem of design, manufacturing and analysis of tow-steered printed composite materials. The program will act as a pre-echo, a precursor, to: 1) implement global/local models for the simulation and analysis of VATs with unprecedented accuracy from fibre-matrix to component scales; 2) develop a (hybrid) metamodeling platform based on machine learning for defect sensitivity and optimization; and 3) set new rules and best-practices to design for manufacturing. A 5-year, highly inter-disciplinary programme is planned, encompassing structural mechanics, numerical calculus, 3D printing and AFP, measurements and testing of advanced composites, data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Traffic through the yeast golgi' under Fourth Framework.

assistant: **Concept**

Research objectives and content The major focus of this proposal is to study the mechanisms of protein transport through the Golgi compartments in yeast. Based on previous studies, transport through the Golgi is thought to be SNARE-mediated. Two v-SNAREs (Sft1p and p28) are known in the yeast Golgi. Moreover, two candidates t-SNAREs (tsx and tsz) have been identified by homology searches and are located in the Trans Golgi Network. We will investigate the role of these proteins in the intra-Golgi anterograde transport using genetic approach and various in vivo functional assays. The oartners of tsx/tsz in SNARE complexes (Sft1p, p28 or others) will be identified. A related study will consist in the characterization of the nature of connections between Golgi compartments. We will try to observe budding and fusion events directly in vivi using the Green Fluorescent Protein technology. Moreover, a cell free functional assay for intra-Golgi transport will be developped. These two methods will be very helpful to determine whether intra-Golgi anterograde traffic is vesicle-mediated and to analyse in detail the biochemical requirements of these transport processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'EU Concerted action: correlates of protective immunity to HIV infection and disease'.

assistant: **Objectives**

To identify immunological correlates of protection from HIV infection and/or progression to AIDS using comparative investigations in human and available relevant NHP systems.Effective vaccination and/or therapeutic intervention to prevent the spread and development of AIDS is likely to require insight into mechanisms of immunological protection from infection and/or disease. Examples of protection from HIV-1 infection are emerging from different clinical as well as preclinical research settings. Vaccine induced protection against HIV-I infection has been demonstrated in chimpanzees, and in the SIV/macaque model. High-risk, exposed humans who remain virus negative appear to have HIV-1 specific cellular immune responses. With respect to disease, progression to AIDS appears to be inhibited in long-term, infected human survivors, and there is a natural resistance to the development of AIDS in infected chimpanzees and in other lentivirus infected African non human primates. Our studies of host-virus relationships may be divided into investigations of (I) - protection from infection (e.g. due to vaccination or repeated low dose exposure); and (II) - protection from disease progression (due to vaccination. immune modulation or natural resistance of the host).I) Infection:a) Vaccine efficacy trials -(HIV-I vaccine immunogenicity studies in humans and in chimpanzees in the developed and developing world)b) Multiple exposure/resistance to infection - in humans chimpanzees and macaquesII) Disease progressiona) Long term asymptomatics (Natural resistance) - humans infected with HIV-I and HIV-2 - Chimpanzees infected with HIV-l - African green monkey infected with SIVb) Acquired resistance to disease - immunotherapy / post-exposure vaccination - infection with attenuated virusesThe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Simulation-Based Corrosion Management for Aircraft' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Corrosion management concepts utilising the application and integration of corrosion predictive tools for corrosion occurrence and corrosion propagation will be a driver for new technical advances in the field of corrosion maintenance and in development of new structural designs, materials and processes for surface protection Additional benefits can be expected by reduced time to market for new products. SICOM will develop a numerical microscale model to simulate localised corrosion of Al-Alloys with regard to microstructure and the micro-electrochemical condition. It will provide corrosion rates of Al-Alloys in the mesoscale of occluded cells by means of numerical calculation as a function of physical and geometrical factors for given macro-environments to simulate crevice corrosion. A numerical model for prediction of galvanic corrosion behaviour will be developed and upscaled for application to structural elements of aircraft. The influence of surface treatment on modelling results will be included with regard to inhibitor release from protection systems, role of clad layer and oxide degrading effects. A decision support tool will be established to enable exploitation and implementation of the project results in scientific and technical applications. SICOM will provide models that will become an essential part of future predictive maintenance concepts to avoid unanticipated and unscheduled maintenance with high costs. Data from monitoring systems and non-destructive inspection can be used as model input. Models output will be utilised for the repair decision process or can supply structural integrity concepts & hereby fill the gap between monitoring or inspection and calculation of the structural impact of corrosion. Aircraft development costs will be reduced through