RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Untapping the potential for improved female reproductive healthcare: diagnosing and reinforcing the status of UTERINE-associated fertility' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Conception and pregnancy are both complex processes, with approximately 1 in 6 women worldwide experiencing infertility, often due to compromised uterine function, the organ designed solely for sustaining life. However, these dysfunctional uterine mechanisms remain not fully understood. Moreover, assisted reproduction technologies (ART) are employed to address infertility, with 5% of newborns in Europe conceived through ART. Nevertheless, the use of ART still results in low pregnancy success rates, with uterine dysfunction being a significant factor. This underscores the importance of the uterus in medical research, which has previously received little attention for its pivotal role in the journey towards motherhood.The TULIP consortium focuses on emerging topics, including the interplay between glycosylation and the microbiota within the uterus in relation to fertility. This interdisciplinary consortium comprises experts from six European countries, representing eight academic and four industry partners, and uniquely combines specialists in female reproductive medicine with researchers in glycobiology, microbiota studies, genomics, and data science. We aim to achieve a breakthrough in understanding the core biological aspects of conception, thereby fostering accurate and less invasive diagnostic methods that lead to more effective and personalised implementation of ART through pioneering tools designed to overcome poor reproductive outcomes.This breakthrough will be achieved by engaging 33 early-stage researchers in a collaborative interdisciplinary training and research programme. The programme seeks to emphasise scientific knowledge while fostering entrepreneurial and transferable skills over the 48-month project period. Collectively, these efforts enhance diagnostic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Optoelectronic medicine - nerve cell regulation with light' (OPTEL-MED).

assistant: **Concept**

Bioelectronic medicine today is growing in leaps and bounds, with ambitious new technologies entering the clinic and already changing the lives of more than a million patients worldwide. Materials scientists are called to craft biomedical devices that are smaller, smarter, and less invasive. We propose to create implantable photovoltaic devices which can wirelessly stimulate the nervous system and enable a new type of minimally invasive optoelectronic medicine. To achieve this, we will use biocompatible organic semiconductors which can efficiently absorb light in the near infrared part of the spectrum, where biological tissues are transparent. By micropatterning stimulation pixels on ultrathin conformable substrates, we will create optoelectronic nerve cuff electrodes which will be orders-of-magnitude thinner than what is used clinically today. We will explore deeply the physics of this new type of electrolytic photovoltaic stimulator. The designs will be optimized to operate with safe light intensities delivered from outside of the body. Benchmarking the targeting of precise optoelectronic stimulation will be done in ex vivo and in vivo nerve models. Via control of spatial patterning and localized light actuation, we will develop unique understanding of highly specific and nuanced neural control. The unique aspect of precise neuromodulation wirelessly positions us to explore a number of fundamental questions in applied neuroscience. The project is driven by answering milestone scientific questions in device physics, photoelectrochemistry, and electrophysiology, however the project is simultaneously designed to tackle an important clinical application: vagus nerve stimulation (VNS). We will apply our findings to implement an implantable stimulator actuated transcutaneou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Towards solving myopia: from genes to pathways using an integrated approach'.

assistant: **Innovation**

Background: Myopia (near-sightedness) is a growing public health issue due to its rapidly rising prevalence. In particular high myopia carries a significant risk of blindness for which there are no treatment options. The disease etiology of this trait is complex and largely unknown. We recently identified a large number of disease loci and genes, which provide significant clues for pathogenic pathways. However, they explain only a limited proportion of myopia’s heritability, and the direct functional effects of risk variants, their interaction with environmental factors, and their potential for intervention are unknown.Aim: To identify disease mechanisms that underlie myopia and create starting points for therapy.Approach: 1. Decipher the genetic background of myopia, identify gene effects and influence of environment in humans. In very large consortia (~250,000 study participants) with ample data on epidemiology, myopia phenotype, and genomic markers, we will exploit the recent technological advances to analyze a large number of genetic variants including those altering protein function. We will annotate significant hits to major pathways, study gene effects on phenotype, identify retinal cell structures which drive myopiagenesis, investigate gene-environment interaction, and develop a prediction model for progression to high myopia.2. Identify gene effects, influence of environment, and targets for intervention in animals.In mice and zebrafish which have been manipulated for high myopia risk genes, we will study ocular biometry, retinal anatomy, visual behavior, and molecular and biochemical effects of genes as a function of environment. Interventions tailored to altering gene effects will be explored. Impact:Integrating the results obtained from these genetic, epidem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Controlled Environment Agriculture Development for Space and Earth'.

assistant: **Innovation**

As astronauts stay for extended periods away from Earth, material recycling becomes ever more essential. As present regenerative Life Support Systems (LSS) are physical-chemical based, they have no capacity to produce food and, thus, do not provide for closure of the human crew inputs and outputs. Bioregenerative LSS become more advantageous in comparison to traditional based LSS especially for distant and long duration missions where resupply becomes too costly. Their benefit stems from the ability to provide edible biomass production, carbon dioxide absorption, oxygen generation, water recycling and waste degradation. Evidence also suggests that the use of higher plants could provide the crew with psychological benefits on long duration space missions.The achievement of closed bioregenerative LSS will only be possible through the continued advancement of a number of Controlled Environment Agriculture (CEA) technologies. These technologies attempt to better monitor and control the various environmental variables that influence plant growth. Efficient lighting and advanced nutrient control systems are two CEA technologies that would provide considerable benefit from the perspective of generating high yield, low waste bioregenerative LSS and better permit sustained human presence in extreme environments such as Antarctica or on other planetary surfaces e.g.  Moon or Mars.The overall objectives of the CEADSE IIF-Proposal are to develop and test innovative technologies that will significantly enhance the reliability of controlled environment food production while providing deep insight into plant-environment interactions not yet available to plant researchers. In particular, we propose to utilize the pull of space technology by advancing the readiness of CEA technologies,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Establishing services enhancing the innovation management capacity of SMEs by the Enterprise Europe Network in North Rhine-Westphalia, Germany, in 2020-21' (2014-2020).

assistant: **Innovation**

Innovations and thus also the management of innovations are of great significance for the competitiveness of the European Union, its Member States and their regions. Innovative individuals or enterprises do something which cannot be expected from the state of the art. They put innovations into practice – generally in the face of considerable resistance – and take financial, technical as well as social risks. Only in this way, however, can new technologies, processes, products or services assert themselves and future markets evolve. Employment, prosperity and the general quality of life and of the environment are directly dependent on the innovation capacity of regions and enterprises. Due to this interrelationship, the European Commission has promoted the Enterprise Europe Network since 2008 in order to provide local support above all to SMEs in the areas of internationalization, technology transfer and generally in the realization of innovations. One of the Network’s tasks is to raise the effectiveness and efficiency of innovation management in SMEs in order to accelerate the implementation of economically impactful innovations.Supporting SMEs in the area of innovation is a core task and the mission of ZENIT, coordinator of NRW.Europa, the Enterprise Europe Network node in North Rhine-Westphalia in the project Innovation.NRW. Whilst innovations naturally cannot be forecasted, they can, however, evolve under the right conditions and be successfully managed. Our understanding of innovation and innovation management is oriented at business opportunities. As a consequence, ZENIT is pursuing the different objectives in the Innovation.NRW project to maintain and expand the innovation capacity and competitiveness of the participating SMEs.In addition, ZENIT supports the benef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Electroactive Biofilms for Microbial Fuel Cells and Biosensors' (EA-BIOFILMS) under Seventh Framework.

assistant: **Objectives**

Electroactive biofilms are capable of extracellular electron transfer and are therefore relevant to geochemistry, biocatalysis, and energy production. Although electroactive biofilms are widely applied in microbial fuel cells (MFCs) for renewable electricity production, where they transfer electrons to solid electrodes, the extracellular electron transfer chain is not completely understood. This lack of knowledge is an obstacle to the development of efficient bioelectrochemical devices, such as biosensors, biocatalyst and innovative MFCs. In order to solve this problem, we will grow known electroactive biofilms in multiple electrochemical cells with potentiostat control and determine the limiting steps in the extracellular electron transfer chain. We will use a combination of electrochemical and biochemical methods to characterize the electrode-biofilm interface. We will then screen environmental samples from metal-contaminated subsurface environments using a combination of enrichment methods, metal-reduction assay and electrochemical methods. By this token, we expect to identify microbial consortia which possess higher efficiency in extracellular electron transfer. The best electroactive biofilms will be grown in MFCs. We expect to increase 10-fold the electrical power output and to make MFCs applicable to a wider range of electrical and electronic systems. Lastly, we will develop the first amperometric biosensor for environmental monitoring of acetate based on electroactive biofilms. The proposed project will produce innovative research in two strategic European areas of applied biotechnology, namely renewable energy sources and industrial biosensors. During the four years of research, we will collaborate with engineers, microbiologists, and electrochemists from resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'From maps to principles: Syntactic cartography and locality in adult grammars and language acquisition' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The project aims to break new ground in syntax and acquisition by combining three main strands of research:1.The cartography of syntactic structures, which attempts to draw detailed maps of syntactic configurations.2.The theory of syntactic locality, with special reference to intervention and delimitation principles.3.The minimalist investigation of the fundamental ingredients of syntactic computations.Interconnected issues of cartography and locality will be addressed both in the adult grammar, and in language  acquisition.There is much to expect from a close integration of these  domains, which can complement and strengthen each other in substantive ways. The acquisition component introduces important variations on the theoretical themes, thus crucially enriching the empirical basis of the theoretical component; reciprocally, the solid theoretical structure of the project will offer new explanatory dimensions and generate novel research questions for acquisition studies.The “complementizer system”  is one privileged  locus where cartography and locality meet, as much of the movement action targets  this zone of the syntactic tree. The research will then primarily focus on this area.The project aims at opening new paths ini.The “further explanation” of cartographic sequences and delimitation effects;ii.The development of a full-fledged theory of syntactic movement, integrating cartographic studies with minimalist syntax;iii.The exploration of a unified approach to intervention and impenetrability locality principles;iv.An integrated study of locality in adults and children,v.The study of the acquisition of cartographic structures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Understanding the role of parvalbumin interneuron development in schizophrenia using human cerebral organoids' (2014-2020).

assistant: **Concept**

Neuropsychiatric disorders account for 1/5 of the total disease burden in Europe causing mental anguish and decreased quality of life for those affected, especially for schizophrenia patients.  An intriguing theory suggests that altered brain development results in schizophrenia, and the selective cellular defects in parvalbumin (PV) inhibitory interneurons observed in schizophrenic patient brains.  However, the role of altered interneuron development in producing these pathophysiological hallmarks of schizophrenia is currently unknown due to a lack of cellular models of human interneuron development.  Cerebral organoids are a revolutionary in vitro model of embryonic brain development generating complex brain circuits and recapitulating many aspects of interneuron development.  The generation of organoid tissue from hiPSCs allows for the growth of patient-specific brain tissue.  Therefore, the current proposal will develop a cerebral organoid schizophrenia model to analyze PV-interneuron development.  First, cerebral organoids will be grown from patient-derived hiPSCs genetically modified to include a PV-GFP reporter.  Using this reporter, genome-wide PV-specific gene expression will be analyzed to identify deregulated developmental pathways during PV-interneuron development.  Second, a phenotypic analysis of PV-interneuron development will determine how PV-interneuron synaptic morphology and/or migration are altered in this cerebral organoid schizophrenia model.  These assays are relevant to disease-related pathology, and will include axonal morphological analysis and a novel organoid co-culture migration assay.  These results will determine the role of interneuron development in the pathophysiology of neuropsychiatric disease for the first time in human tissue.  Unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Regional railway transport research and training centre foundation', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The aim of the project is to found an international research and training centre in the field of railway transport, which will integrate the efforts for developing modern, competitive, safe and comfortable railways on the Balkans. The Center will be based at the Todor Kableshkov University of Transport in Sofia. The participants in the project will elaborate its statute, structure, organization and strategy oriented to enlarge the scope, of integrated research and training activities in the field of surfa ce transport. The Center will be open for membership to all research and educational institutions in the region. The RRCT will provide the necessary human and information resources; will organize conferences and seminars on topical issues connected with the Trans-European transport corridors passing through the region; will enable the exchange of scientific information and staff; will develop new university courses in compliance with the requirements of ECTS (European Credit Transfer System) and cours es for long life training; will create working and expert groups and coordinate the research and technical activities for achieving sustainable railway transport on the Balkans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a biochip to monitor cardiac wellness' (CARDICHIP).

assistant: **Concept**

The objective of the TOK project will be the development of a novel bio-diagnostic device, for the rapid and precise detection of a panel of 7 known risk factors for CVD. By monitoring these known risk factors it will be possible to detect the early stages of CVD before the appearance of clinical symptoms. This will allow doctors and patients to take preventative actions (therapeutic options or changes to lifestyle) to prevent the progression of/to CVD, resulting in reduced patient morbidity and mortality, allowing significant improvements in patient quality of life and longevity, keeping patients out of hospitals, and saving healthcare costs. The availability of this simple test for use in a doctors office or even in the home will allow for improved outcomes for patients, through early diagnosis and management of disease and offering a holistic approach to preventative medicine. The cardiac wellness biochip will integrate diverse technologies - multiple biological recognition, with highly sensitive signal generation and detection - onto a unique microfluidic platform. The resultant test will be easy to use, simple and cheap to manufacture and produce results in minutes. The test methodology will involve the addition of a small drop of blood from a finger prick onto the device.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Structure and function in macromolecules'.

assistant: **Concept**

The aim of this study is the construction of a model of the immunocomplex between the MIR decapeptide and anti-AChR autoantibodies So that these data may be used for the design of high affinity therapeutic antibody fragments. The known NMR structure of the MIR decapeptide, when bound to the antibody molecule, will be used for docking experiments to the known crystal structures of Fab198 and Fab192. The crystal structures of Fab192 and Fab198 subsequently wiII be used in conjunction with the molecular modeling structures of two other anti-AChR monoclonal antibodies (Fab35 and Fab195), in order to combine elements of their structure with known characteristics of their function, The above experiments will show the nature of the interaction between the monoclonal antibodies and the antigen (AChR) and important residues for this reaction wiII be revealed. 3. OBJECTIVES AND EXPECTED ACHIEVEMENTS a. Models of Fab 35 and Fab195 based on homology modeling experiments. b. Docking of the Fab molecules to the known NMR structure of the MIR decapeptide c. Determination of antibody residues with important structural and functional importance d, Design of mutant molecules with possibly higher affinity for human AChR