RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Chemical and thermodynamic modeling of petroleum formation and evolution in the earth'.

assistant: **Innovation**

According to conventional wisdom, oil generation from kerogen is caused by increasing temperature and time during progressive burial of source rocks in sedimentary basins (Tissot and Welte, 1984). However, this paradigm has come into question in recent years with growing recognition of the likely dependence of kerogen degradation and the maturation of petroleum on the dramatic decrease in oxygen fugacity with increasing depth in these basins. In order to determine which hydrocarbon species are favored by thermodynamics to predominate in kerogen, bitumen, and petroleum with increasing depth of source rock burial, comprehensive Gibbs free energy minimization calculations will be carried out with the aid of computer code EQ3NR (Wolery, 1991) using values ofthe standard molal thermodynamic properties of high molecular weight hydrocarbons computed by Richard and Helgeson (1996), together with those reported by Helgeson et al. (1996) for their lower molecular weight counterparts. The results of these calculations will then be compared with reported compositional data to determine the extent to which they agree with geologic reality.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Aligning Brain Rhythms: Understanding the mechanisms of cortical tracking of speech to improve language functions with real time closed-loop neurofeedback' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Speech processing and reading are essential unique human abilities underpinning social, educational, and professional advancement. However early biomarkers for learning disabilities such as Developmental Dyslexia (DD) and for second language learning have yet to be identified. Here, cutting edge neuroimaging tools, carefully designed tasks, and longitudinal designs will be used to record cortical tracking of speech (CTS), namely, the temporal alignment between fluctuations in the speech signal and fluctuations in electrical brain activity across different populations. Specifically, we will investigate the predictive ability and causality of CTS 1) at an early age in language development, 2) for second language learning, reading, DD and illiteracy, 3) establish the domain-specificity of CTS as ‘biomarker of language processing’, and 4) pioneer a real-time closed-loop neurofeedback protocol modulating CTS to adaptively change language processing and learning through neurofeedback. This project represents a radically new scientific approach that will break new ground by investigating the predictive ability of CTS that combined with longitudinal designs and real-time closed-loop neurofeedback will allow us to (1) establish causal relationships and (2) use this novel approach to improve L2 learning and to diagnose and remediate DD.


**Keywords:** Language,  Oscillatory activity,  Cognitive psychology,  Developmental dyslexia,  Literacy,  Brain stimulation,  Brain plasticity,  Sign language,  Visual attention,  Language rhythms,  Cognitive neuroscience,  Longitudinal designs,  Neurofeedback,  Closed loop,  EEG,  MEG,  MRI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Impacts Quantification of global changes' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

World societies experience today large transformation processes both in the social, economic and environmental dimensions. These transformations are usually described under the heading of ‘global change’, to emphasize the increasing interactions between them. The objective of the proposal is three-fold: (1) to provide significant advances in the estimation of socio-economic impacts of global challenges – at Global, European and regional scale; (2) to identify optimal adaptation strategies; (3) to evaluate total costs and the optimal mix of adaptation and mitigation against global changes. Work Package (WP) 1 will examine the sources, interactions and characteristics of global changes, including the emergence of fast-growing economies, environmental degradation, competition on the use of exhaustible resources, international competitiveness issues. A primary objective of the proposal is to estimate socio-economic impacts arising from global changes by using economic models. The consortium is endowed with a large set of state-of-the-art, internationally renown, modeling tools. Models will be further expanded and enriched in WP 3. Key areas of research will be: agriculture, forestry, land use, energy, EU competitiveness, labor, international trade. The socio-economic impact of these challenges on key sectors/areas will be examined with the enhanced set of models in WP 4 and WP 5. While in WP 4 impacts of global challenges will be studied assuming limited adaptive capacity, in WP 5 optimal adaptation strategies will be examined. WP 5 will also inform on total costs of global challenges and on the optimal mix of mitigation and adaptation. In WP 2 will develop empirical and theoretical insights on key issues which will have a value per se and will also be used to enhance model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Basic Research in Cryptographic Protocol Theory' (BRiCPT) under Seventh Framework.

assistant: **Objectives**

In cryptographic protocol theory, we consider a situation where a number of entities want to solve some problem over a computer network. Each entity has some secret data it does not want the other entities to learn, yet, they all want to learn something about the common set of data. In an electronic election, they want to know the number of yes-votes without revealing who voted what. For instance, in an electronic auction, they want to find the winner without leaking the bids of the losers.A main focus of the project is to develop new techniques for solving such protocol problems. We are in particular interested in techniques which can automatically construct a protocol solving a problem given only a description of what the problem is. My focus will be theoretical basic research, but I believe that advancing the theory of secure protocol compilers will have an immense impact on the practice of developing secure protocols for practice.When one develops complex protocols, it is important to be able to verify their correctness before they are deployed, in particular so, when the purpose of the protocols is to protect information. If and when an error is found and corrected, the sensitive data will possibly already be compromised. Therefore, cryptographic protocol theory develops models of what it means for a protocol to be secure, and techniques for analyzing whether a given protocol is secure or not.A main focuses of the project is to develop better security models, as existing security models either suffer from the problem that it is possible to prove some protocols secure which are not secure in practice, or they suffer from the problem that it is impossible to prove security of some protocol which are believed to be secure in practice. My focus will again be on theoret
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Scaling up iPSC Expansion and Differentiation using Recombinant Bioemulsions' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Advances in stem cell technologies have revolutionised cell therapy and advanced in vitro models, but remain limited by our ability to scale up and automate cell manufacturing. In particular, induced pluripotent stem cell (iPSC) expansion and differentiation require complex processing protocols that are preventing the wider deployment of associated technologies to the clinic and industry. Although solid and hydrogel microcarriers have displayed potential in addressing this challenge, they present hurdles to the processing and separation from cell products, leading to contamination of the generated cells, the poor control of their phenotype and high production costs. Developing cost-effective, scalable, and regulatory-compliant platforms for culturing, differentiating and processing iPSCs, while circumventing reliance on solid substrates and microcarriers, remains critical for advancing cell manufacturing and will significantly impact the sustained growth of associated biotech markets. To mitigate contamination risks, streamline bioprocessing, and reduce associated costs, bioemulsions have emerged as promising alternatives. Despite their demonstrated performance in a growing range of cellular contexts, current underpinning protein and polymer nanosheet technologies raise concerns regarding regulatory compliance, for broad application in regenerative medicine. We propose the engineering of recombinant protein nanosheets for the stabilisation of biomedical grade oil microdroplets, that will tackle these challenges and allow the production of bioemulsions in a scalable format, aligned with regulatory expectations. The ability of the resulting bioemulsions to sustain the culture of iPSCs and their differentiation into defined lineages will be validated and this technology wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European Schoolnet Living Schools Lab' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The LivingSchoolsLab project is a 24-month Coordination Action with 15 partners, including 12 Ministries of Education (MoE) or organisations nominated to act on their behalf. It is coordinated by European Schoolnet (EUN) that has extensive experience of demonstrating and showcasing best practice involving ICT use in schools and in coordinating large-scale, pan-European school pilots and validations both within EC-funded projects and for industry partners.Showcasing innovation in schools in the network will be based on systematically observing and documenting classroom practice and teachers in the network will be upskilled as a result of continuing professional development activities.Rather than reprising previous models for school networks involving only eMature schools, EUN and its supporting Ministries will put in place a new, multi-layered network or ecosystem involving, not only 'vanguard' schools, but also schools, classes and individual teachers at very different levels of ICT implementation. This will support the development of whole school approaches to ICT deployment and the mainstreaming of innovative practice that is increasingly seen as critical by both MoE and the Commission.The project will improve the coordination of research by: producing 'baseline' validation methodologies, a validation manual and running workshops so that existing projects can more quickly design, cost and implement their own validation pilots; offering a fully costed, turnkey validation service to different stakeholders that, after the end of the project, will be sustained as a core service activity within the EUN Future Classroom Lab. Key to this will be the development of a new economic model for an expansion of the network which recognises that, if we wish to involve large numbers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Amyloid fibril cytotoxicity: new insights from novel approaches' under Seventh Framework.

assistant: **Concept**

Despite the discovery of amyloidosis more than a century ago, the molecular and cellular mechanisms of these devastating human disorders remain obscure. In addition to their involvement in disease, amyloid fibrils perform physiological functions, whilst others have potentials as biomaterials. To realise their use in nanotechnology and to enable the development of amyloid therapies, there is an urgent need to understand the molecular pathways of amyloid assembly and to determine how amyloid fibrils interact with cells and cellular components. The challenges lie in the transient nature and low population of aggregating species and the panoply of amyloid fibril structures. This molecular complexity renders identification of the culprits of amyloid disease impossible to achieve using traditional methods.Here I propose a series of exciting experiments that aim to cast new light on the molecular and cellular mechanisms of amyloidosis by exploiting approaches capable of imaging individual protein molecules or single protein fibrils in vitro and in living cells. The proposal builds on new data from our laboratory that have shown that amyloid fibrils (disease-associated, functional and created from de novo designed sequences) kill cells by a mechanism that depends on fibril length and on cellular uptake. Specifically, I will (i) use single molecule fluorescence and non-covalent mass spectrometry and to determine why short fibril samples disrupt biological membranes more than their longer counterparts and electron tomography to determine, for the first time, the structural properties of cytotoxic fibril ends; (ii) develop single molecule force spectroscopy to probe the interactions between amyloid precursors, fibrils and cellular membranes; and (iii) develop cell biological assay
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Micro-ring resonator-based biophotonic system for food analysis' under Seventh Framework.

assistant: **Concept**

Current methodologies for detection of food contamination based on heavy analytical tools cannot guarantee a safe and stable food supply. The reasons are the complexity, the long time-to-result (2-3 days) and the cost of these tools, which limit the number of samples that can be practically analyzed at food processing and storage sites. The need for screening tools that will be still reliable but simple, fast, low-cost, sensitive and portable for in-situ application is thus urgent. BIOFOS aims to address this need through a high-added value, reusable biosensor system based on optical interference and lab-on-a-chip (LoC) technology.To do this, BIOFOS will combine the most promising concepts from the photonic, biological, nanochemical and fluidic parts of LoC systems, aiming to overcome limitations related to sensitivity, specificity, reliability, compactness and cost issues. BIOFOS will rely on the ultra-low loss TriPleX photonic platform in order to integrate on a 4x5 mm2 chip 8 micro-ring resonators, a VCSEL and 16 Si photodiodes, and achieve a record detection limit in the change of the refractive index of 510-8 RIU. To support reusability and high specificity, it will rely on aptamers as biotransducers, targeting at chips for 30 uses. Advanced surface functionalization techniques will be used for the immobilization of aptamers, and new microfluidic structures will be introduced for the sample pre-treatment and the regeneration process. BIOFOS will assemble the parts in a 5x10x10 cm3 package for a sample-in-result-out, multi-analyte biosensor. The system will be validated in real settings against antibiotics, mycotoxins, pesticides and copper in milk, olive oil and nuts, aiming at detection below the legislation limits and time-to-result only 5 minutes. Based on the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'REsidual soft WOod conversion to high characteristics drop-in bioFUELs' to be submitted under Horizon 2020.

assistant: **Abstract**

REWOFUEL goal is to demonstrate the performances, reliability, environmental and socio-economic sustainability of the entire value chain, for the transformation of residual soft-wood into hydrolysate (RWH), conversion of RWH into bio-Isobutene (bio-IBN) by fermentation and further conversion to biofuels. To achieve these goals a team of 11 partners, leaders in their field, originating from 7 EU-member states, will join efforts.REWOFUEL consists in showcasing the value chain, from residual wood to 3 high performance drop-in biofuels derived from bio-IBN. These biofuels are full-bio-ETBE, bio-isooctane and bio-isododecane rich biofuels. This large market is today supplied entirely by products derived from fossil-based IBN. Products derived from bio-based IBN, using the same process as fossil-based IBN, would provide a true renewable alternative.REWOFUEL includes the development & up-scaling of this process and the valorization of coproducts: lignin, microbial biomass, biogas and fertilizers. To this end, four ambitious objectives were defined:-Demonstrate the production of residual wood hydrolysate (RWH) and establish a quality standard to feed the IBN fermentation unit,-Demonstrate the production of bio-IBN-based biofuels from RWH at pre-commercial scale,-Demonstrate the valorization of lignin and other coproducts resulting from the RWH process,-Determine and validate the targeted technical, safety, economic as well as environmental/social sustainability performances to be achieved for a commercial plant.This project aligns with the core innovation strategies of 2 SMEs which are: deconstructing of wood (SEKAB, SWE) and conversion of sugars/hydrolysates into bio-IBN (GBE, FR). These 2 SMEs are already operating a demo plant that they intend to further upgrade within the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Low Data Machine Learning for Sustainable Chemical Sciences' (LowDataML), addressing dissemination and exploitation.

assistant: **Impact**

Innovation in the chemical sciences is bound to iInnovation in the chemical sciences is bound to impact on Healthcare and Society. Supported by improved analytical methods and automation, brute force and large-scale experimentation have been playing an important role in generating volumes of chemical and biological data. These data now enable the support to decision making through machine learning/artificial intelligence (ML/AI) algorithms. In doing so, such algorithms help in the design and prioritization of experiments. As a result, we are witnessing a renaissance of ML/AI for accelerating chemistry, as in planning retrosyntheses, predicting reaction products, designing drug leads and materials de novo, and deconvoluting drug targets among others. Despite the chemistry advances leveraged by ML/AI, one can argue that not all research questions and findings benefit from the availability of big data (e.g., some discoveries are serendipitous). Here we argue that the current ML/AI toolkit excels in scenarios (big data) that do not entirely map onto daily practice (low and sparse data, often out of training set distribution). Thus, the scientific potential of ML/AI is not fully realized when state-of-the-art tools are implemented and primed for big data and highly charted search spaces. The disconnect between what is feasible and generally needed is apparent and is impacting our ability to advance the chemical sciences at a faster pace. In LowDataML we propose a suite of intersectional and transdisciplinary research projects that will create a new breed of scientists. Through an extensive training program, we will deliver 10 PhDs to the European R&D ecosystem, who are experts in low data ML with domain knowledge in synthetic organic chemistry and drug discovery. Further, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Smart and local reneWable Energy DISTRICT heating and cooling solutions for sustainable living' to be submitted under Horizon 2020.

assistant: **Abstract**

The overall objective of WEDISTRICT is to demonstrate DHC as an integrated solution that exploits the combination of RES, thermal storage and waste heat recycling technologies to satisfy 100% of the heating and cooling energy demand in new DHC and up to 60-100% in retrofitted DHC.  For this purpose, the focus of WEDISTRICT is large-scale replication of best practice: better valorisation of local resources, like renewable and waste heat by making District Heating and Cooling networks more efficient in relation to the use of new resources. In parallel, systems will evolve to provide even more flexible solutions by the integration of innovative molten-salts based thermal storage, the interaction with other energy networks (electricity and gas) and the involvement of end-users (operators and consumers) through ICT-based control and decision making. Finally, to enable significant expansion, cost-effectiveness will be enhanced by transitioning from handicraft to more industrialised solutions that integrate LEAN methodologies to optimise processes and lower costs.


**Keywords:** District Heating and Cooling, Intelligent optimisation and control, prosumers, citizens engagement, smartcity, energy efficiency, renewable energy