RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The ecological drivers of species radiation in island mammals. The case of the Cretan deer.'.

assistant: **Concept**

By their own very nature, islands are natural laboratories where evolutionary outcomes seem to exceed the limits of imagination. Stubby and flightless birds, dwarf elephants and hippos, and giant mice are some of the bizarre examples. Those morphological modifications are not the result of random variation but are triggered by the specific ecological conditions of the islands (absence of terrestrial predators and low level of competition for food and space). In some occasions, these conditions do not lead to a particular shift in body size, but instead to a diversification event, resulting in a disparity of forms, such as the case of Darwin’s finches in Galapagos. The island of Crete (Greece) housed one such diversification, that of the enigmatic extinct Pleistocene deer. This genus (Candiacervus) evolved into eight species in six size groups, ranging from ~28 to ~245kg in body mass, in less than 1 million years. In CREDE I will explore this unusual disparity of body size in Cretan deer to understand the evolutionary mechanisms behind species radiations in mammals. Despite advances over the years in knowledge on this lineage, mainly focusing on dwarf or giant species, we know little about the factors underpinning this level of diversity. In CREDE I will employ my expertise in deer bone histology together with the novel application of 3D image analysis to examine bone microstructure of Cretan deer, and thus, obtain data about their life strategies (age at maturity, pace of growth, longevity). Moreover, the use of stable isotope will provide new integrative data on the ecological and dietary preferences of the different species. Finally, the combination of both approaches will shed light on diversification of mammal lineages on a macroevolutionary scale, presenting a comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Manipulating and Imaging Stem Cells at Work' (ManISteC).

assistant: **Concept**

Stem cells are promise and threat at the same time. To understand how stem cells act it is crucial to study their behavior in their natural context. Following and manipulating an individual stem cell and its descendants on their path to differentiation has so far not been possible. We have recently developed new microscopy and image analysis tools that allow long term in vivo observations. Novel genetic tools allow to stochastically label individual cells and thus to follow all descendants derived from the cell initially marked. We have modified and adapted this technology for the fish system and will extend its potential to allow functional clonal analysis in vivo. The transparent fish medaka (Oryzias latipes) and zebrafish (Danio rerio) are ideally suited to combine advanced imaging and the genetic lineage manipulation of stem cells. This way the influence of genetic pathways implicated in cell proliferation and differentiation is directly addressed in vivo. Clones originating from single wild type or manipulated cells are followed in their in vivo context and the physiological consequences of this manipulation is directly measured. Individually labelled clones will be followed by DSLM 4D microscopy over periods of up to 7 days in juvenile and adult fish. We will interfere with signaling pathways and key transcription factors in these cells combining the brainbow approach with lineage specific gain- and loss-of-function. That way a specific color will indicate a specific experimental condition. We will focus on the path of decisions taken by retinal stem cells and their descendants on the one hand and on cells composing induced tumors on the other. This will be highly relevant for our understanding of stem cell and tumor cell proliferation and differentiation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'From mechanical stress to vascular fate'.

assistant: **Objectives**

In the vascular system, cell phenotype and fate are driven by the mechanical environment. Whereas physiological mechanical stress defines and stabilizes normal cell phenotype, aberrant mechanical signals trigger phenotypic alteration, leading to inflammation and vascular remodelling. Despite recent advances, how mechanical cues impact gene expression to specify cell phenotype remains poorly understood.Our hypothesis is that mechanical stresses are transmitted to the nucleus where they activate signaling pathways, which in turn regulate gene expression, but what are these mechanotransduction mechanisms occurring within the nucleus? Besides, while most vascular cells respond to mechanical force, Resident Stem Cells (RSCs) are virtually insensitive and remain undifferentiated despite constant cyclic stretch. What are the molecular mechanisms which protect RSCs from stretch-induced differentiation?To answer these questions, we designed an interdisciplinary proposal which gathers biophysical, biochemical and genetic assays, with the following objectives: I) To determine how nuclear mechanotransduction pathways regulate vascular cell phenotype in response to mechanical cues. By combining proteomic and biophysical assays, we will identify nuclear proteins that are post-translationally modified in response to mechanical stress, then we will determine their contribution to gene expression regulation and vascular cell differentiation. II) To identify the molecular mechanisms which protect RSCs from stretch-induced differentiation. We will identify differentially expressed force-bearing structural elements in RSCs compared to more differentiated vascular cells and we will evaluate their impact on gene expression, stress transmission, RSC differentiation and blood vessel formation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Swedish Presidency SET-Plan Conference', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

On the occasion of the Swedish Presidency, the Swedish Energy Agency is organising a conference on the 'European Strategic Energy Technology Plan' (SET-Plan). The conference will take place in Stockholm, 21-22 October 2009 and will allow the participation of about 500 people. The objective of the conference will be to give momentum to the implementation of the SET-Plan, which was adopted by the Commission on 22 November 2007. In particular, the conference will seek to generate impetus for the proposed European Industrial Initiatives.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Producing graphene from biogas: an innovative, renewable and cost-effective value-chain for industrialising the material of the future'.

assistant: **Concept**

It is expected that graphene demand will sharply grow in the next years, and is a priority for the EU to lead its production globally.In the agri-food industry and wastewater treatment plants, anaerobic digestion is a proven technology for treatment of wet-waste biomass, which allows generation of biogas as renewable energy. Additionally, biogas can be upgraded into biomethane and CO2, which are organic carbon sources which can be used as raw materials for manufacturing graphene in a circular economy approach: biographene.We are Biogenera Renovables, and we have developed a plug-and-play solution for producing graphene from biomethane in biogas plants via Chemical Vapor Deposition (CVD). We have a working prototype of the technology (now TRL6) in collaboration with PlanarTech, another R&D intensive SME key in graphene industrialisation, and we are finetuning an innovative business model to have a long-term leadership.Our business model consists in partnering with biogas plants to install our Biographene Production Unit in their premises, as well as sharing the profits of the sales. It will allow graphene production to be economically viable at industrial scale and simultaneously is a way to increase the profitability of biogas plants and boost the renewable energy sector. To market it, we will explore how to collaborate with PlanarTech.Our breakthrough technology coupled with the business model proposed has the potential of transforming the industrial production of graphene, whose high-quality production will be sold to technological industry, and its low-quality fraction will be sold to packaging industry, which is currently highly interested in incorporating graphene to strengthen their materials (reinforcing paper pulp for bags).From 2022 to 2026, 12 BioGraphene prod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'A bioinformatic investigation of the mutation process using genomic data'.

assistant: **Objectives**

Mutation is the ultimate source of all genetic variation, including the variation that is responsible for genetic disease. It is therefore important to understand the process by which mutation occurs.The principal aim of the proposed work is to gain a better understanding of the process of mutation in the genome of several species including our own. In particular, it will be investigated whether there is variation in mutation rate on a fine-scale such that adjacent bases can have different rates of mutation.Moreover, it will be studied whether sequence- or template- directed mutagenesis is prevalent in the human genome, whether it may generate disease causing mutations and whether it is responsible for compensatory evolution. The analysis will be performed on DNA sequence data, including whole genome sequences from several species, using bioinformatic and statistical approaches.It is anticipated that the work will shed new light on the process of mutation and how genetic variation is produced. It is also anticipated that the work will substantially increase our understanding of molecular evolution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Majorana Networks' to be submitted under Horizon 2020.

assistant: **Abstract**

The aim of the proposed research project is to establish a new environment for the generation, study and manipulation of Majorana fermions, namely two dimensional electron gases embedded in III-V semiconductors with strong spin-orbit interaction. With respect to the nowadays approach, based on nanowires, two-dimensional materials will allow completely new sample design, paving the way for precise control and complex manipulation of Majorana modes. The ultimate goal will be the realization of multi-terminal networks, where the braiding statistics of Majorana fermions will be investigated. The success of the proposed project will constitute a key advancement for the use of Majorana fermions as tools for quantum computing applications. We will make use of recently developed tools and materials to solve the nowadays technical difficulties in taking experiments on Majorana fermions to a new level.For our research, we will adopt InAs\InGaAs quantum wells, characterized by strong spin-orbit interaction and large Landé g-factor, coupled to superconducting electrodes. As shown by preliminary results, the quality of our InAs samples is unique in terms of mobility and gate stability. The researcher’s expertise in quantum transport is a good match to the wide experience of the host institution in terms of quantum computation and semiconductor/superconductor hybrid devices. The availability of the state of the art cryogenic equipment, including vector magnets, will allow to experimentally explore completely new regimes in condensed matter physics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for '2nd European workshop on animal cell engineering' to be submitted under Fifth Framework.

assistant: **Abstract**

Cell engineering is developing rapidly as an exciting and enterprising field in biotechnology. Its emergence reflects the need to produce complex proteins for use as therapeutics to a very high degree of fidelity and has been facilitated by rapid progress in molecular biology, molecular genetics and bioengineering. Further stimulus has come from exciting developments in tissue engineering, which offer tremendous potential for the development of replacement tissue and even whole organs. Integrating the advances in molecular biology into bioprocesses presents a continuous challenge to scientists and engineers in this field. This workshop is conceived to help us meet this challenge.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Merkel cell polyomavirus Oncogenic Network' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The aim of the MONET project (Merkel cell polyomavirus Oncogenic Network) is to provide a state-of-the-art understanding of Merkel cell carcinoma (MCC) tumorigenesis. Viral pathogens are estimated to be responsible of ~12% of cancers worldwide and represent useful models for the study of oncogenesis mechanisms. Merkel Cell Carcinoma (MCC) is an aggressive neuroendocrine skin cancer detected in ~2500 patients per year in Europe and has recently been linked with a clonal integration of the Merkel Cell polyomavirus (MCPyV) in more than 80% of cases. MCPyV is a 6-protein encoding system, expressing only two proteins with reported oncogenic functions. This limited proteome size thus allows system-wide study of its associated oncogenic mechanisms. This multi-pronged project consists of: (i) identifying the critical interactions of viral and host proteins in MCC oncogenesis; and (ii), using NOD scid mice cell line derived xenografts (CDXs), validate MCPyV host-proteins drug targeting strategies to combat MCC tumorigenesis. Using cutting-edge mass spectrometry-based techniques combined with CRISPR interference approaches in relevant human cancer cell systems, these studies will uncover new protein-protein interactions essential for tumorigenesis. MCPyV+ MCC CDXs will be used to establish the functional relevance of novel virus-host protein interactions and to assess the therapeutic potential of targeting these host interactors as anti-cancer strategies. The application of these proteomic and functional approaches will allow for a better understanding of MCPyV-associated carcinogenesis. In a broader view, it will define a new framework for identifying druggable targets in pathogen-driven cancers. This project will underpin future translational researches, and hence appears as a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'BOrdDErGuArd - Proactive Enhancement of Human Performance in Border Control' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

BODEGA for Proactive Enhancement of Human Performance in Border ControlBODEGA project will  investigate and model Human Factors in border control to provide innovative socio-technical solutions for  enhancing border guards’ performance of  critical tasks, support border management decision-making, and optimize travellers’ border crossing experience. BODEGA will develop a  PROPER toolbox which integrates the solutions for easy adoption of the BODEGA’s results by stakeholders in border control. PROPER toolbox which will integrate  ethical and societal dimensions to enable a leap of  border control  towards improved effectiveness and harmonisation across Europe.The PROPER tools will be co-designed and thoroughly validated with relevant stakeholders and end-users. The work will be carried within the framework of Responsible Research and Innovation to ensure the ethical and societal compatibility of the project work and provided solutions as well as emphasis on the foreseen future with smarter borders. With its focus on in-depth understanding of the human factors in border control and PROPER toolbox, BODEGA will enable a leap of European border guard culture towards professionalism.BODEGA validated, modular and flexible toolbox will enhance the performance of border control stakeholders - border guards, border authorities and citizens - to create more secure, efficient and effective border crossing, focusing on the borders between Schengen agreement and external countries. A holistic view of the Human Factors with respect to the Smart Borders will be developed. The project focuses on human and organizational factors of border control technologies and processes and examines the effects of introducing innovative technologies into key border guard tasks, traveller’s performance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Signal Formation in Synaptic Circuits with Astroglia' under Seventh Framework.

assistant: **Concept**

In the past decade, astroglia have emerged as an active and critical partner in neural circuit communication in the brain, in health and disease. However, the increasing variety of mechanisms which reportedly contribute to astroglia-neuron signal exchange is nearing a conceptual bottleneck. How these multiple and diverse mechanisms relate to the functional organisation of astroglia, whether this relationship persists or whether it adapts to neural activity remains poorly understood. Building upon substantial preliminary work and extensive collaboration, our overall objective is to establish principles that guide signal formation, integration and propagation in neural circuits interacting with astroglia. We will focus mainly on hippocampal circuitry and combine single-cell electrophysiology, multi-photon excitation imaging, time-resolved and super-resolution fluorescence microscopy, pharmaco- and optogenetic tools and extensive biophysical and neural network modelling. Firstly, we will establish whether and how glia-neuron signal exchange relates to the structure and function of individual synaptic connections represented by postsynaptic dendritic spines and presynaptic axonal boutons. Secondly, we will identify cellular mechanisms by which individual astrocytes integrate, in space and time, calcium signals arising from distinct types of local physiological input. Thirdly, we will determine physiological machinery that prompts use-dependent, meta-plastic changes in the neural circuit-astroglia exchange and in glial signal processing. Fourthly, we will establish the relationship between neural network oscillations and periodic activities of astroglial assemblies. Finally, we will undertake a computational and theoretical analysis of principles that govern the role astrogl