RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Innovative Glycan-based analysis for Cancer diagnostics' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Worldwide, there are 1.6M new prostate cancer (PCa) cases with 366k deaths annually. Novel PCa biomarkers are needed since the best current PCa biomarker (prostate specific antigen (PSA)) lacks PCa diagnostic accuracy often resulting in mistreatment of PCa patients. The false-positive rate of PSA in blood serum is ~75%. PSA test is applied together with digital rectal examination (DRE) for preliminary screening. If the combined results are suspicious, the patients undergo a biopsy to confirm PCa. Yet, there are 74% of needless biopsies representing a significant pain for PCa patients and societal/economic burden.Based on a great commercial outcome from the ERC grant (311532) granted to Dr. Jan Tkac (co-founder/CSO of Glycanostics), the company has developed an innovative, non-invasive, early PCa diagnostics using blood serum. Instead of quantifying PSA, the innovative PCa diagnostic assay detect glycan changes on PSA protein (it discriminates between “healthy” PSA and “sick” PSA and accurately quantify the clinically relevant “sick” PSA). The technology is covered by two EPO patent applications owned by the company. The PCa diagnostic test with 95% accuracy will be applied as a 2nd opinion test in case of suspicious results from PSA & DRE examinations prior sending to a biopsy. PCa DX kit will be launched for clinics/hospital & cancer centres (B2B) and Prostate check home test for user-friendly application at homes (B2C).Our PCa diagnostic technology is unique compared to our competitors focusing on analysis of other complex biomolecules such as a level of proteins, mRNA and circulating DNA. Moreover, we have competitive advantage over competitors in terms of cost per sample, assay accuracy, simplicity of the assay enabling the home testing and high-throughput.Glycanost
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Neuroethology of olfaction in Drosophila' (NEUROETHOLOGY).

assistant: **Concept**

ABSTRACTDrosophila melanogaster has become a prime insect model for studying olfaction. Research on insect olfaction has provided many valuable insights in neural processes involved in sensory coding and processing. Due to its well-defined genome D. melonogaster olfactory circuitry is increasingly understood. Many question, however, remain. Here we propose to study the neuroethology of Drosophilae using a comparative approach. A closely related sibling of D. melonogaster, the insular species Drosophilae echolalia, is unlike its siblings a specialist, preferring Orinda fruit. The fruit is toxic for D. echolalia\'s sibling species including D. melanogaster, and concordantly they are repelled by its odour. The required shifts in D. echolalia\s olfactory circuitry remain unstudied, however. Using D. melanogaster, Drosophilae stimulants, Drosophilae Mauritania, and D. echolalia, we will pinpoint the changes in the olfactory circuitry associated with this shift from repulsion to attraction. For this we will use a multidisciplinary approached involving analysis of the volatiles of Orinda fruit, analysis of the volatiles to which the flies are sensitive, both physiologically as behaviourally, testing differences in the peripheral olfactory system between the species, using single sensible recordings and morphological studies, and revealing what impact the observed changes have had on the wiring and physiology of the olfactory circuit in the antennal lobe, the first relay centre of olfactory information. Such information will be extremely valuable in understanding the ecological significance of olfaction in Drosophilae, the organisation and evolution of olfactory circuits, and its relationship to behaviour. More generally, we will gain insight in what may mediate radical shifts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Harmonic analysis on and geometry of fractal sets' (1994-1998).

assistant: **Concept**

Research objectives and content It is proposed to tackle problems in the area of intersection of geometric measure theory and harmonic analysis, focussing particularly on the interaction between geometric and analytic properties of sets. Proposed problems include: 1. providing a geometric characterization of general 1-dimensional subsets of the plane of analytic capacity zero, 2. investigating implications of L2-boundedness of various singular integral operators (in particular, discovering for which such operators L2-boundedness implies rectifiability), 3. discovering whether a set in the plane which has projections onto lines of positive length in almost every direction must have bounded Melnikov curvature, 4. understanding asymptotic doubling properties of general sets, 5. investigating relationships between Poincari and Trudinger inequalities, doubling or strong doubling conditions, and the geometry of sets. Training content (objective, benefit and expected impact) The proposed collaboration would strengthen the preexisting links between NUIM and the applicant's current institution, the University of Jyvdskyld. (The two departments are currently part of a network, and a number of members of staff collaborate regularly.) The applicant's previous training in geometric measure theory and real analysis, and the host's expertise in harmonic analysis, make collaboration on such problems very natural. The proposed project would also broaden the applicant's range of expertise, while building on her current research knowledge. Links with industry / industrial relevance (22) None.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advanced Damage Detection though Optical sensor Network' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The main objective of the ADD-ON (Advanced Damage Detection though Optical sensor Network) project is to investigate the feasibility of developing an unique Optical Sensor Network (OSN) to control the various classes of distributed and punctual optical sensors. This solution can monitor, in a variety of profiles of use (in-flight monitoring, on-ground operation), the SHM measurands of interest: delamination, corrosion, cracking, loading and can simultaneously sustain data transfer… This OSN will be designed starting at its conception phase in order to facilitate its integration into aircrafts, considering the specific environmental constraints of aerospace. Several challenges will have to be overcome during the 45-months project, to attain this main objective in collaboration with the Topic Manager. • First, demonstrate the feasibility of using a low cost sensor for delamination and damage detection based on waveguides inscribed into a sol-gel matrix able to be deployed on large surface. • Second, optimize a loading measurement chain based on FBG and using an integrated photonics system all-at-chip level adapted to the aircraft avionics needs. • Third, investigating the feasibility of self-diagnosis for the OSN. During the ADD-ON project, the potential of the OFDR, BOFDA and HR-OTDR sensing techniques will be more particularly evaluated and the best solution will be selected and tested on the small-scale prototype panel (in-lab validation).The ADD-ON concept, methodology, flowchart and associated tasks, subtasks to achieve these goals will be detailed in this proposal. The results from ADD-ON will lead and/or contribute to the following benefits:• Reduction of manufacturing cost due to higher integration• Weight reduction due to multidisciplinary optimization including
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A joint doctoral program to educate tomorrow’s insect pathologists: Solving disease problems in the upcoming insect rearing industry.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Mass rearing of insects is a rapidly expanding industry due to improved mechanisation and increasing interest in the use of insects for a variety of purposes, such as sterile insect techniques, food and feed, waste management, and biocontrol of insect pest species. However, expertise is urgently needed to address emerging problems with infectious disease outbreaks in mass reared insects. Therefore, we propose the INSECT DOCTORS joint doctoral programme to build a durable European framework to educate experts in insect pathology in order to overcome the shortage in properly educated experts in Europe, and beyond. The research of INSECT DOCTORS will expand our understanding of emerging pathogens and will provide necessary tools for disease management in industrial insect rearing. The complementary expertise of the participating institutes and companies leads to an ambitious and exciting programme, providing interdisciplinary training and research in pertinent areas of insect pathology (bacteriology, mycology, virology) and entomology (immunology, physiology). In an overarching training program, novel advanced courses will provide students with technical, scientific and transferable skills. This interdisciplinary approach, crucial to provide insight in the complexity of insect-microbe interactions in a range of farmed insects, can only be achieved by joining forces between European universities. Furthermore, this joint doctoral programme aims to build durable partnerships for doctoral training in insect pathology, thereby overcoming national and interdisciplinary boundaries in doctoral research. By requiring equal excellence from all participants in this training programme we will contribute to high level PhD education across Europe. In short: INSECT DOCTORS will provide t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Enhanced VAccines DEsign against antimicrobial REsistance' to be submitted under Horizon Europe.

assistant: **Abstract**

EVADERE (Enhanced VAccines DEsign against antimicrobial REsistance) is a multidisciplinary consortium of 14 interna-tionally recognised experts (12 from academia and 2 from industry) from 9 European countries who will provide 15 doctor-al candidates (DCs) with high-quality inter-sectoral training in discovery and development of vaccines targeting antimicro-bial resistance (AMR) based on innovative antigens, adjuvants, and delivery methods. Trainees will acquire a broad range of transferable skills to underpin their resilience for future careers in vaccine research within academia and industry respecting gender and equality.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Research and Preparedness Network for Pandemics and Emerging Infectious Diseases' in the context of a Horizon 2020 call.

assistant: **Objectives**

The overall objective of this 5-year project is to build a multinational, adaptive European COVID-19 and emerging infectious diseases trial network, based on existing initiatives, experience and expertise, allowing European expansion of DisCoVeRy (WP1) and the establishment of a COVID19 adaptive platform trial (WP2). The DisCoVeRy trial, designed as a multi-arm adaptive repurposing trial, initiated in France, has the potential to expand to many other European countries with appropriate support in terms of multinational funding and trial management capacity. This will complete the evaluation of repurposed drugs, while building a European clinical trial network which, together with other European networks such as the Solidarity trial, will design and run a new European platform trial. EU-RESPONSE will swiftly generate robust evidence for drug repurposing or registration, through a modular trial framework allowing most European hospitals to participate at their preferred level of commitment, thus building a network of investigation sites within European and associated countries. Cooperation with other European platforms, in particular the RECOVER consortium platform will be achieved through a joint coordination mechanism aligned with European and national policies (WP3), ensuring a coordinated strategy for the European COVID-19 Adaptive Platform Trials, their complementarity in providing access for requests for a new domain or arm, their synergy and cross-fertilization through the development of a common toolbox for the development and the management of Adaptive Platform Trials. Joining forces in Europe and with international partners, it will contribute to the global clinical trial capacity for urgently meeting the expectations of society and developers. It will also boos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PV light weight facade elements with improved power utilization' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The aim of the project is to develop photovoltaic facade elements for buildings, which combine maximum energy efficiency with attractive appearance and flexibility in building design. A further objective is to develop a flush-mounting system with laminated backsheet, where no parts protrude from the surface. These facade elements will be developed in cooperation with an industrial designer in view of meeting the expectations of architects.The project work will result in the development of:- a DC/DC converter for individual photovoltaic facade elements- a flush-mounting photovoltaic facade element with only one glass layer on the front, which will be easy to mount and allow for cooling by backventilation, thus increasing efficiencyThe project partners intend to further develop the combination of both these technologies in view of entering the emerging photovoltaic facade market.Technical Approach   Varying conditions of light, shade, and sun exposure result in variable energy outputs. Present solutions to this problem use parallel and series connections, where shade can interrupt the energy output of an entire row of photovoltaic cells. To avoid this effect, shadowed parts of facades often have normal panels, while panels exposed to the sun are photovoltaic. This results in heterogeneous facades and unattractive appearance. In order to overcome these difficulties, a conversion device will be developed. This device will transform the voltage of photovoltaic sub-units, which may be of different size and have different voltage outputs, to a uniform voltage level of e.g. 200 V. This DC voltage will be connected to a common busbar. The busbar can then feed an energy grid using a single DC/AC converter. This solution will offer a greater efficiency and lower cost than the use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Novel Nanocomposites for Hydrogen Storage Applications'.

assistant: **Objectives**

In order to meet the international goals for hydrogen storage materials, the work in NANOHy aims at combining the latest developments in the metal hydride field with novel concepts for tailoring materials properties. Leading expertise in the field of complex hydride synthesis, synthesis and functionalization of nanostructured carbon, nanoparticle coating, structural characterization, and computational methods will be joined to achieve a fundamental understanding combined with considerable practical progress in the development of novel nanostructured materials for hydrogen storage. The target materials are nanocomposites consisting of hydride particle sizes in the lower nanometer range which are protected by a nanocarbon template or by self-assembled polymer layers in order to prevent agglomeration. Thus, there is potential to lower working temperature and pressure, to enhance the reversibility, and to control the interaction between the hydride and the environment, leading to improved safety properties. Materials of this kind can mitigate or solve principal and practical problems which have been identified recently in other projects. The composites will be synthesized out of novel complex hydrides with very high hydrogen content and nanocarbon templates. Alternatively, hydride colloids will be coated in a Layer-by-Layer self-assembling process of dedicated polymers. Computational methods will be used to model the systems and predict optimal materials/size combinations for improved working parameters of the systems. Sophisticated instrumental analysis methods will be applied to elucidate the structure and the properties of the nano-confined hydrides. An upscale of the target nanocomposite will be made in the final stage and 0.5-1 kg of the material will be integrated and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantum computation in Europe pathfinder project' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The deliverables from this project are a report and a workshop. This report will contain:- A listing of people and organisations active in Europe, a lexicon and annotated bibliography.- Definitions, bounds and classifications of activities in the areas of `quantum information'. This information will include sector by sector inter alia:- the scientific basis and state of the art: real world problems this technology may address, problems to be overcome; potential timetables and beneficiaries; and an assessment of their commercial potential.- An assessment of the state of the art of these technologies in relation to known activity in other centres of excellence outside Europe.- Suggested areas of further basic research; - Proposals for ensuring continuing dissemination of information - Finally a directory will be set up listing all organisations and people active in Europe in this field, and a database of relevant projects in Europe, a lexicon of terms and an annotated bibliography will be established. This information will be made available both on a web site and in printed form.While it must be recognised that the goal of useful Quantum Computation may not be achieved for some years, it is believed that there will be valuable spin-offs along the road. Work on the subject may improve our understanding not simply of physics and nonotechnology, but also of the human brain; developments in secure communication and in holography may be achieved. When finally reached, the ultimate goal will impact on many aspects of computing, not just through a massive increase in power, but also through the opening up of new fundamental approaches to information retrieval. The challenges thrown up are ones that will stimulate and attract the best minds of young workers of the age into physic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Metabolic Targeting of GnRH Neurons: Molecular Mechanisms and Neuropeptide Pathways' (META-GNRH).

assistant: **Innovation**

Reproduction, an essential function for perpetuation of the species, is under the control of a sophisticated network of regulatory signals, which include nutritional cues and metabolic factors. Disorders of reproductive maturation (puberty) and function are becoming increasingly common in Europe, and other developed countries, and appear to be linked to the rapid increase in metabolic disorders within the community ranging from energy insufficiency to obesity. It is suspected that information on metabolic status is integrated into the control of fertility at the level of the GnRH neuron, the key cell regulating fertility in all mammalian species. How this occurs is not known. The global aim of this project is to gain insight into the neuroendocrine and molecular mechanisms responsible for the metabolic regulation of puberty and fertility, and their eventual alteration in conditions of disturbed energy balance. To this end, a combination of in vivo and ex vivo approaches, using conventional and genetically-modified rodent models, will be implemented in order to evaluate (i) the effects of selected metabolic hormones (ghrelin) and metabolic neuropeptidergic pathways (NPY, AgRP, alpha-MSH) on GnRH neuronal activation, and (ii) to analyze the putative role of the sensor of intracellular energy status, mTOR, in mediating the actions of the above signals on GnRH neurons. It is anticipated that implementation of the project will expand greatly our knowledge of the physiological and pathophysiological mechanisms underlying the metabolic control of reproduction. In addition, completion of the proposed workplan will allow the applicant to get acquainted with powerful genetic methodological tools that will strengthen further his experience in neuroendocrinology, boosting his futur