RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Resolving spinal cord cell type evolution with single cell sequencing' in the context of a Horizon 2020 call.

assistant: **Objectives**

The emergence of vertebrates was accompanied by a major increase in nervous system complexity, as a sophisticated brain and spinal cord evolved to process enhanced sensory input and direct co-ordinated motor output. Such complexity is achieved by an increase in cell number, a greater diversity of cell types and sophisticated mechanisms to organise them. Is has long been debated whether the “2R” whole genome duplications, which occurred just before the vertebrate split, contributed to the vertebrate increased complexity. To address this, we will focus on the lamprey spinal cord –a representative of the first branching vertebrates – and relate gene duplication events to the emergence of new neural cell types. Bulk RNA sequencing and developmental studies have started to shed light on neural patterning mechanisms in lamprey, but they do not provide cellular resolution in this complex tissue. This proposal combines traditional molecular methods with cutting-edge single cell mRNA profiling, to explore (1) the cellular diversity of the lamprey spinal cord, (2) the molecular mechanisms that specify those cell types and (3) the evolutionary origins of these mechanisms. First, I will identify marker genes that define specific cell types in lamprey embryonic spinal cord. Second, I will characterise each cell type transcriptional profile at single-cell resolution. Third, I will manipulate pattering signals and assesses the effect on gene expression, particularly on 2R paralogs. Finally, I will compare the lamprey spinal cord to that of other chordates, and relate gene duplication to the evolution of new cell types.This project will generate a cellular atlas of the lamprey spinal cord, which will be the framework for future studies, and shed light onto whether the 2R genome duplica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Plants in search of water: physiological and molecular interplay between root hydraulics and architecture during drought stress'.

assistant: **Objectives**

Plants have to constantly adjust their water status during development and in response to very changing environmental conditions, recently increased by climate change. By exploring the soil and taking up water, plant roots play a crucial role in these processes. Drought exerts deep effects on root functions by altering root cell water permeability (hydraulics) and modulating the growth and architecture of the root system. Water channel proteins named aquaporins adjust root hydraulics in response to many stimuli, including drought stress. Auxin plays, together with abscisic acid (ABA), a pivotal role in root growth and development and regulates aquaporins during lateral root formation (LRF). The present project proposes a frame for integrating these effects by exploring functional links between root architecture, aquaporins and hydraulics, phytohormones, and modelling. Responses to water stress will be studied from the elementary level of LRF up to the whole root level to identify complex interactions and signalling pathways. The Arabidopsis root was chosen as a model for accelerated discovery, as it allows a unique combination of developmental biology, genomics, biophysics and mathematical modelling, with the purpose to transfer this knowledge to crops. This novel and multidisciplinary project will be carried out by a researcher with a strong scientific expertise on agriculture and plant molecular physiology which perfectly matches the proposed project. The latter will be implemented within a consolidated group and an internationally recognized institution (Aquaporin team, BPMP, CNRS/INRA/SupAgro/UM2 Montpellier, France). This combination provides a unique scientific platform for the research training of the applicant and the development of frontline research in plant s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Molecular and cellular determinants of cell monolayer mechanics'.

assistant: **Objectives**

Epithelial monolayers are amongst the simplest tissues in the body, yet they play fundamental roles in adult organisms where they separate the internal environment from the external environment and in development when the intrinsic forces generated by cells within the monolayer drive tissue morphogenesis. The mechanics of these simple tissues is dictated by the cytoskeletal and adhesive proteins that interface the constituent cells into a tissue-scale mechanical syncitium. Mutations in these proteins lead to diseases with fragilised epithelia. However, a quantitative understanding of how subcellular structures govern monolayer mechanics, how cells sense their mechanical environment and what mechanical forces participate in tissue morphogenesis is lacking.To overcome these challenges, my lab devised a new technique to study the mechanics of load-bearing monolayers under well-controlled mechanical conditions while allowing imaging at subcellular, cellular and tissue resolutions. Using this instrument, my proposal aims to understand the molecular determinants of monolayer mechanics as well as the cellular behaviours that drive tissue morphogenesis.  I will focus on four objectives: 1) discover the molecular determinants of monolayer mechanics, 2) characterise monolayer mechanics, 3) dissect how tension is sensed by monolayers, and 4) investigate the biophysics of individual cell behaviours participating in tissue morphogenesis.Together these studies will enable us to understand how monolayer mechanics is affected by changes in single cell behaviour, subcellular organisation, and molecular turnover. This multi-scale characterisation of monolayer mechanics will set the stage for new theoretical descriptions of living tissues involving both molecular-scale phenomena (cytoskel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cloud-native ultrasound imaging', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Ultrasound (US) can revolutionize and democratize medical imaging if it offers: (1) access for everyone, and (2) excellent image quality, always. MRI offers (2) but is expensive and will thus not likely be able to provide (1). Low-cost US hardware will enable (1) in the future but is not expected to yield the needed breakthrough for (2). Any solution that addresses both will have a huge impact.The biggest adversaries for US image quality stem from patient- and user-specific factors. I therefore strongly believe that achieving (2) requires closed-loop, goal-directed imaging through systems that actively pursue information gain, in-situ. My ERC stg project US-ACT develops this new closed-loop US paradigm, with deep generative models governing beliefs about anatomy and function. This, however, gives rise to a new dilemma: How to embrace high-performant, but complex, algorithms to achieve (2), while at the same time lowering cost to achieve (1)?  Our recent result shows that US-ACT enables breaking the cost-complexity trade-off, through a new approach that is rooted in the closed-loop proposition itself.I propose CloudSound, a fully cloud-native US imaging paradigm, unlocking access to virtually unlimited computational power, memory, and storage for raw US sensor data. We will move all the computational complexity away from the local device to a remote server. To achieve this with minimal latency and high frame rates, CloudSound introduces a new holistic rate control strategy for the entire transmit-receive scheme, based on algorithms developed in US-ACT. This will drive rate control of the full solution under a time-varying information bottleneck: the network channel.Ultimately, CloudSound will disrupt ultrasound business models and unlock unprecedented image quality and e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Optical signal regeneration in slow light silicon waveguides' (OSIRIS) targeting Seventh Framework.

assistant: **Abstract**

In modern optical communication systems, signal degradation in the optical channel caused by dispersion, nonlinearity and noise in the fibre is a critical issue. This issue is currently addressed with electronic devices using optical-electronic-optical (oeo) conversion, which are inefficient and expensive. Low power all-optical data processing devices, such as all-optical regenerators, offer an alternative solution. Optical regeneration can be promisingly performed using the four-wave mixing effect and is intended to reshape, re-amplify and retime the signal in the optical domain, which removes the need for oeo conversion and is transparent to the data rate. OSIRIS proposes to develop a multichannel regenerator based on four-wave mixing. The regenerator will be based on a photonic crystal waveguide that exploits slow light effects. Ideally, the FWM effect can be enhanced by the fourth power of the slowdown factor. This significant effect allows us to reduce the length of the device or the pump power, or both. OSIRIS will explore the extent to which this exciting promise can be realised in practise. The work will be based on specifically engineered slow light waveguides that the applicant developed during a 6-month visit to St. Andrews in 2007. Achievement of this goal will be demonstrated by realising efficient optical regeneration in an engineered slow light photonic crystal waveguide of only 100's of micrometres in length, using only mW's of optical power. This corresponds to two orders of magnitude improvement or better in device performance compared to the State-of-the-Art.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ECO-INNOVATIVE PROCESSING TECHNOLOGY FOR BETTER QUALITY AND SHELF LIFE OF FISH PRODUCTS' (ULTRAFISH).

assistant: **Concept**

Fish stock management in European waters is becoming increasingly important, as it is necessary to ensure the long-term sustainability of fish catch and conserve marine resources. The fish processing industry plays a key role in this strategy, being responsible for ensuring proper handling and preservation of fish products to retain its quality and to increase its shelf life in the market. Aligned with the ""Blue Growth Strategy"" (COM (2012) 494), Scanfisk, a Spanish company based in Zaragoza specialised in fish processing of fresh & frozen products, has developed ULTRAFISH. The project aims at improving today's processes related to handling and processing of fishery products (fresh and primary processed) by applying a green and innovative technique based on the use of ultrasound to eliminate the use of chemical additives for microbial inactivation. This safe and environmentally friendly processing technique will be implemented at different water-based stages to reduce the processing times and water waste generated in these stages in a cost-effective manner. By implementing ULTRAFISH, Scanfisk will lower their costs and time of their processes, able to save time, money and energy, and to produce fishery products with longer commercial shelf life. This will enable them to increase their margin and market share, and to enter new markets which to date were not considered. The EU market will benefit from higher value-added products, to cope with increasing consumer demands, and it will be provided with a novel food treatment technology that significantly contributes to the sustainable management of fish stocks.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Support EO-driven forest and carbon monitoring in Central Africa for REDD' (REDDINESS).

assistant: **Concept**

REDDiness is a development project built on an international partnership between state-of-the-art entities specialized in forest management and earth observation techniques that aims to assist Gabon and the Republic of Congo in establishing their national forest monitoring centres. With its foundations on existing EC, ESA, GMES and other international and regional projects on forest assessment, forest mapping and carbon trend estimation, the project will increase the readiness of these countries to join the carbon trade market and strengthen their capacity to negotiate potential carbon transactions. The partnership assistance will focus on transferring optimal robust spatial methods to enhance the monitoring of forest changes and enable the precise assessment of annual carbon emissions from deforestation and degradation. This will be achieved through a better operational use of existing methodologies and the introduction of innovative techniques to meet UNFCC technical requirements for measuring, reporting and verifying (MRV) forest changes and associated carbon emissions. The project’s overarching objective is to assist Gabon and the Republic of Congo to accurately report on the rate of deforestation which they committed to reduce from 0.19 down to 0.10% by 2017.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'TechNovator XE remote wireless charging' (TechNovatorXE).

assistant: **Concept**

The number of electronic devices that people use in their everyday life is continuously growing. However, it becomes increasingly difficult for people to monitor and timely recharge all the batteries. The necessity of monitoring the level of gadgets charging keeps users on constant tenterhooks. Also, environmental problems are a big issue: with the increasing number of electronic devices, the amount of wires, cords and batteries increases dramatically, and they are rarely being recycled. Even under the conditions of Batteries Directive the realistically achievable share of collected waste is only 30-40%. The emergence of a wireless charger that synchronously charge all of the nearby devices, would greatly facilitate people’s life. According to Global Market Insights, the wireless charging market worth $3.67 billion in 2016 (grew around 40% compared to 2015), and is projected to reach $25.67 billion by 2023. However, all existing wireless charging solutions available on the market are actually not remote, as they require gadget to be placed on the charging pad and it cannot be moved until fully charged.TechNovator XE (TRL 6), developed by TechNovator, is a unique remote wireless charging solution that effectively charges multiple devices simultaneously at a long distance within range of the transmitter (5 meters radius), and is completely safe for people and the environment. The system also has a unique feature “battery charging level control” that is achieved through constant battery level monitoring and autonomous charge if it is below the certain level that the user can set up in the application.To ensure successful commercialization, in Phase 1 of SME Instrument, TechNovator intends to develop an elaborate feasibility study for TechNovator XE remote wireless charging
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advanced tools for the management of electricity grids with large-scale wind generation' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Nowadays, wind power has an increasing share in the electricity generation mix in several European countries. Due to the intermittent nature of wind, the large-scale integration of wind power causes several difficulties in the management of a power system. Often, a high level of reserves is allocated to account for wind power variability, thus reducing the benefits from the use of wind energy.Today it is widely recognized by end-users such as Transmission System Operators, utilities a.o. that forecasts of the power output of wind farms up to 48 hours ahead contribute to a secure and economic power system operation.  The FP5 project ANEMOS (ENK5-CT-2002-0665) has successfully developed research on new forecasting techniques for a wide range of end-user requirements. The aim of the ANEMOS.PLUS proposal is to fully integrate the forecasts and their uncertainty into the management and decision support tools.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovation Denmark' under Horizon 2020.

assistant: **Concept**

The Danish EEN will provide skilled Innovation Management Capacity Building personnel to provide two services: Key Account Management Services to SMEs in the SME Instrument and Innovation Management Capacity Building services to potential high growth SMEs. A total of minimum 20 service packages will be implemented. Two tools will be used to carry out these tasks - Growthmapper for the KAM role, to provide a brief and simple feedback on the company's management ability and IMP3rove for all IMCB cases, to provide a thorough picture of the innovation management capacity of the SMEs. Companies in the IMBC work will be integrated with the wider Danish and European innovation support eco-system.


**Keywords:** Innovation Management, Key Account Management
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'METAbolism of bone METAstasis (META2): Metabolic interactions between disseminated breast cancer cells and osteoblast lineage cells drive bone metastases formation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Triple negative breast cancer cells (TNBC) metastasize to the bone, resulting in progressive bone destruction and severe complications for the patient. TNBC colonize the bone already much earlier, but they often stay dormant for several years and remain undetectable. Recent studies showed that at this early stage, TNBC cells are in close proximity to bone-forming cells (osteoblasts), and this interaction promotes TNBC survival and proliferation. Interestingly, recent findings also indicate that the metabolism of tumor cells not only drives primary tumor growth, but also determines which cells will metastasize to lung or liver, indicating metabolic interactions of TNBC with their microenvironment. This concept may also apply to TNBC in bone, but insight in the metabolism of TNBC colonizing the bone is lacking. I hypothesize that to survive and thrive in the bone TNBC cells rely on a specific profile that is complementary in nutrient needs to osteoblasts. Accordingly, preliminary results of the lab showed that targeting glutamine pathway impaired bone metastasis formation. Thus, my objective is to characterize the metabolism of TNBC in bone at early time points and to validate that targeting this metabolism will limit or prevent bone metastasis. I will first perform metabolite dosage and transcriptomics on TNBC recovered at early stages of preclinical (mouse) models of bone metastasis. In parallel, I will decipher metabolic interactions in vitro between osteoblasts and TNBC using metabolomics. These two complimentary approaches will deliver fundamental insights into metabolic adaptations of TNBC during bone metastasis, and identification of the most interesting enzymes to target. I will then validate these targets through functional studies in preclinical models and analy