RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Functional and Molecular Analyses of the Interplay between Hematopoietic and Mesenchymal Niche Cells in Human Myelodysplastic Syndromes.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Myelodysplastic syndromes (MDS) are heterogeneous clonal hematopoietic stem cell diseases mainly affecting the elderly (45/100,000 in >70 years). The prevalence of MDS is expected to rise mainly as a result of an aging population. MDS is characterized by ineffective production of mature blood cells with peripheral cytopenias and the propensity to evolve to acute myeloid leukemia. Most MDS patients rely on continuous blood transfusions resulting in significant costs to healthcare systems and, most importantly, secondary effects leading to complications and patient deaths. The only potential curative treatment for MDS is hematopoietic stem cells (HSC) transplantation, which is limited to younger patients with suitable donors (<10% of MDS patients). Increasing evidence indicates that myeloid neoplasms can be triggered by abnormal functional properties of the bone marrow microenvironment in mice. However, it remains to be seen whether this also applies to human hematopoietic neoplasms. Our work revealed that patient-derived mesenchymal niche cells are essential to propagate human MDS HSCs in vivo, thus highlighting the crucial role of the niche in human MDS. Moreover, our data indicate that human MDS hematopoietic cells may “educate” their niche environment into a self-reinforcing one.The goal of our proposal is to decipher the interplay between hematopoietic and mesenchymal niche cells in human MDS, and to assess innovative means by which we could target diseased cells to improve MDS patient outcomes. We will perform a comprehensive molecular characterization of highly purified primary mesenchymal niche cells to define new prognostic/therapeutic niche factors in MDS. More importantly, we will take advantage of our unique xenograft model of MDS to translate our findings int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New Enantioselective Desymmetrization Reactions in Alkaloid Total Synthesis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This project will develop a new, highly enantioselective, state-of-the-art synthetic route to the daphniyunnine family of alkaloids based on a novel dual organo / metal catalysed desymmetrization reaction of alkene-linked cyclohexanones as a key step, which will allow the rapid and efficient construction of the AB rings ready for subsequent advancement to the majority of the family members. Evaluation of the anti-cancer biological activity of the different target molecules and late stage intermediates will be carried out. This Fellowship project combines total synthesis, new asymmetric methodology development and biological evaluation. It has been designed to augment and complement the research and transferable skills sets of the Marie Curie fellow, Dr Sonawane, and will greatly enhance his career prospects accordingly. Through the training and the research results arising, the Fellowship will be beneficial to the fellow, the host institution and European science.


**Keywords:** Organic synthesis, catalysis, desymmetrization, total synthesis, alkaloids, enantioselective reactions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Nonlinear Evolutions and Iterative Algorithms: Optimization and Control' (NEITALG).

assistant: **Concept**

Iterative algorithms (IA) stand as the very backbone of scientific computing. Traditional IA rely on convex optimization to guide the search for optima, severely limiting their scope to local solutions. Consequently, nonconvex problems are regarded as the ultimate challenge of global optimization. Solving them with convergence guarantees will lead to numerous scientific discoveries, such as finding new medications through optimization of the properties of molecules or enhancing materials for solar cells to accelerate advances in green technologies.The first goal of NEITALG is to design new, efficient, and scalable iterative algorithms that can provably solve relevant nonsmooth nonconvex optimizations. This will allow us to overcome locality barriers and open up an entirely new field in scientific computing.Furthermore, parametric IA, which are tailored to training data —making them learnable IA— are currently driving remarkable advances in computing and machine learning. However, most of these systems lack rigorous guarantees of performance or interpretability of results.The second goal of NEITALG is to formulate new learnable IA with focus on interpretability and generalization guarantees. This will greatly advance the development of safer and more reliable technologies based on machine learning.The key approach to achieve both goals involves the systematic study of the largely unexplored mathematical field connecting iterative algorithms and nonlinear evolutions (NE). NEITALG will1. Explore the principles for which the analysis of NE provides insights into the convergence of an IA; 2. Generate new IA from nonstandard NE to overcome traditional limitations (e.g., locality, lack of interpretability);3. Provide mean-field optimal control theories for new learnable IA; 4.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A holistic approach in patient management and epidemic surveillance through convergence of diagnostic technologies, capacity building and stakeholder engagement' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Research on Poverty-Related Diseases (PRDs) in sub-Saharan Africa suffers from major technological and non-technological challenges that prevent high quality healthcare to reach many areas. Not only their performance, but also the affordability, manufacturability, suitability for Low- and Middle-Income Countries (LMICs) and deployment of the (few) available diagnostics are main barriers to ensure good quality of healthcare in sub-Saharan Africa. The HoliCare project aims to tackle such challenges from a holistic perspective, by bridging the gap between technological excellence, available infrastructures, capacity, and local uptake of new technologies. We have chosen to work with lower respiratory infections as a blueprint for our new approach due to their huge clinical and socioeconomic impact, and relevance to the SARS-CoV-2 pandemic. Technology-wise, we propose a 2-tiered, digitally interfaced diagnostic approach that will start in the field using multiplexed lateral flow tests for rapid screening and triage, followed by a referral to a hospital (when needed) and a follow-up detailed diagnosis using a POC-Instrument performing simultaneous nucleic acid amplification (LAMP) for pathogen identification and immunoassays for host biomarker quantitation. Digital and manufacturing infrastructures will encompass these technology innovations to ensure future local product development. Quality controlled biobanks will be developed for executing reliable clinical studies. Training and human capital investment will be achieved by focussed and high-level training activities. Adoption and implementation activities will pave the way for the proposed diagnostic solutions to be successfully deployed, fitting the purpose of the local populations. Our developments will be scalable, ada
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Building the world’s largest digital hospital for neurological challenges' under Horizon Europe.

assistant: **Concept**

Peili Vision was founded in 2015 based on a vision to help people rehabilitate after traumatic health events, such as stroke. By combining VR technology, artificial intelligence, gamification and the latest science in neurorehabilitation, our mission is to empower every rehabilitee to train in the most effective way and as frequently as possible from the comfort of their own home. Our evidence-based novel rehabilitation methods enable feedback and progress tracking remotely. Remote approach addresses the key bottleneck in this field: lack of rehabilitation professionals, which is why currently the cost of rehabilitation services is very high while the availability is very limited, especially in rural and remote areas.Our first product is designed for speech therapy. In the next phase, with the support of the EIC funding, we will expand our product-service offering to cover the entire patient care path, from remote diagnostics to AI-designed therapy programs and medication evaluation.


**Keywords:** Remote rehabilitation therapy,Neurorehabilitation,Occupational therapy,Neurophysiology,Neuropsychology,Clinical evaluation,Neurological disorder diagnosis,Therapeutic tools,Gamification,Virtual Reality,Speech and language therapy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular Targets of Uranium in some Aquatic Organisms' (MOTAUR).

assistant: **Concept**

Uranium is an important element, massively used in military and civil industry. It is a toxic element and the understanding of the mechanisms of its metabolism, homeostasis and toxicity are of paramount importance. The project aims at the development of a series of novel analytical methods able to identify and quantify the species being products of interaction of uranium with the proteome and metabolome of some aquatic organisms. The organisms include microalgae Fragilariopsis cylindrus and Karenia brevis selected on the basis of reports claiming their unusual toxic metal homeostasis, some shellfish crayfish Orconectes limosus, bivalve Corbicula fluminea known for uranium bioaccumulation, and a model organism zebrafish Danio reiro. The methods to be developed to probe biomolecular targets of uranium include non-denaturating gel electrophoresis with uranium specific laser ablation ICP mass spectrometry imaging followed by canonical proteomics protocols and hydrophilic interaction chromatography with the high-resolution MS detection of uranium complexes present. The maps of the interactions of uranium with biomolecules will be discussed in the context of toxicological data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Prediction of cognitive properties of new drug candidates for neurodegenerative diseases in the early clinical development' (PHARMA-COG).

assistant: **Concept**

PHARMA-COG aims to develop a new integrated model to accelerate the development of drug cindidates for MS, PKD and AD. The innovation relies on a 'multidimensional matrix' approach, integrating all available and renewed inputs (biomarkers/animal, human models/physiological and pharmcological challenges, Phase 0/1/1b to reduce the attrition rate, to allow an early and pertinent GO/NOGO decision before entering phase II trials for both symptomatic treatment and disease modifiers approaches.  The hypothesis is that effective long term drugs will normalize markers artificially modified.  The general objective is to test the efficiency of the 'matrix' on drug candidates for the enhancement/protection of cognitive functions. the final objective is to improve the detection and selection of new drugs candidates within a shorter teim-frame.Our consortium gathers 13 academics and clinicians, 8 SMEs, 1 European patient organization (Alzheimer Europe) as well as 1 regulatory body (EMEA), coming form six different EU Members States.  Excellence Centres gather representatives of the different sectors: biomarkers (proteomics, transcriptomics), pharmacodynamic markers ( electrophysiology, psychophysiology, morphological and functional imaging), preclinical model specialists (cellular, transgenic mouse, monkey), clinicians, and clinical pharmacologists.By the end of this (-year project, the following achievements are expected; definition of the most predictive combination of pharmacodynamic markers; validation of parallel models (in healthy volunteers, ApoE 4 subjects,patients and animals) to establish effective exposure ranges and support proof of mechanism studies. The predictive value of the 'matrix' will be evaluated using different pharmacological target acting drugs.  Suugestions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development of universal vaccinal dendritic cells lines for cancer treatment'.

assistant: **Innovation**

The development of efficient vaccines for the treatment of cancers is a major public health issue but remains a challenge. The induction of cytotoxic specific T cell able to recognize and lyse malignant cells is the main goal of immunotherapeutic strategies based on dendritic cells. The fellow has developed a unique cell line (GEN2.2) from the new Plasmacytoid Dendritic Cell (PDC) type. He demonstrated its tremendous potential in allogeneic setting to induce the activation and proliferation of specific efficient cytotoxic T lymphocytes in vitro (melanoma patients’ samples) and in vivo (preclinical humanized mouse model). Allogeneic PDCs therefore represents a new promising immunotherapeutic strategy to fight cancer. The project aims to create a set of universal “off-the-shelf” dendritic cell lines based on GEN2.2. The current strategy is based on irradiated GEN2.2 loaded with immunogenic peptides derived from tumor antigen presented by HLA-A*0201 allele. This strategy, however, is limited to the patients with the corresponding HLA allele and to the known peptides chemically synthesized. In collaboration with the University College London, the fellow proposes to improve this vaccine strategy by engineering genetically modified cell lines, either coding for i) the antigenic peptide to avoid the loading step, ii) the antigens as the whole protein to enlarge the spectrum of presented peptides, or iii) other HLA class I antigens to target a larger number of patients. This project is ambitious and in the scope of the developments in the immunotherapeutic field. It proposes to enlarge the patient population and the cancers for which this new and promising strategy could be used. The Marie Curie Action proposed here is an adequate opportunity for the fellow to overcome his weak
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Models of lambda - calculus and structural rules'.

assistant: **Innovation**

Functional programming is a declarative method for writing programs. It satisfies some of the basic requirements of the software engeneering. Exactly for these reasons formal methods have been developed for studying the semantics of paradigmatic functional languages. These methods aim to extract operational properties, induced by some given abstract machine, out from denotational properties, induced by mathematical structures (2, 3, 7). This approach implies that it is basic to have a classification as much complete and abstract as possible of the class of the suitable mathematical structures yielding computational properties. In case we take the call-by-name A-calculus AB (1) as paradigmatic functional language, we have a well-known and stable situation, concerning its models. Quite surprisingly, a neat such situation is unknown for the Plotkin's lazy call-by-value A-calculus ABv (5), in spite ABv is the paradigm of real functional programming languages like SCHEME and ML. The aim is to discover at least one definition of model ` la Hindley-Longo for ABv and a categorical description, corresponding each other as for AB. Two steps are planned to obtain the aim. The first step consists of giving a description as much wider and exhaustive as possible of what a categorical model for ABv could be. The second step consists of looking for suitable adaptations of the notion of model a la Hindely-Longo to the various proposals of categorical models, eventually produced by the first step. For developing the first step, we plan both to compare the already existing categorical definitions of models for ABv, Moggi's one and (6), and to find some other proposals by looking at ABv as it were a substructural A-calculus. Concerning the second step of the project, the most general categ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Volatolomic approaches for improving success rates in assisted reproductive technology' (ARTVOC), addressing dissemination and exploitation.

assistant: **Impact**

Volatolomics has emerged as a new frontier in deciphering unreached matters related with health conditions. Volatolomics research is based on the study of the volatile compounds emitted by biological samples. It was demonstrated that the volatiles emitted though breath, skin, feces, urine or cells can provide useful information for the diagnosis of an important number of diseases, such as cancer, diabetes, or even neurodegenerative disorders. We have very recently demonstrated that the embryos do also emit volatiles during their development, while genetical disorders alter the pattern of the released volatiles. In the present project, we aim at assessing volatolomic techniques for the non-invasive assessment of embryos quality in order to select the most viable ones for transfer. The ultimate goal of this project is to achieve higher success rates in the in vitro fertilisation.


**Keywords:** Volatile organic compounds,  Gas chromatography, Mass spectrometry (GC-MS),  Electronic nose,  Embryo, selection,  In vitro fertilisation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Role of Poplar RBOH family protein in ozone-induced oxidative stress: assessment of the protein activity regulation in planta and development of biochemical tools for analysis of the protein funtion'.

assistant: **Objectives**

The increase in tropospheric ozone concentrations has been considered to be one of the major reasons for yield reductions in many crop plants and thus to economically significant losses. Natural environments, and forest stands especially, have received as hare of this pollutant insult.Evidence from previous research indicates that ozone-induced plant responses may be mechanistically similar to pathogen-induced plant responses such as the hypersensitive response. It has been shown by combining localization, enzyme activity and inhibitor studies that the plasma membrane NADPH oxidase, a respiratory burst oxidase homologue (RBOH), is one of most likely candidates for stress-induced reactive oxygen species production in trees.This project will aim to evaluate a role of different RBOH proteins in O3-induced oxidative stress in poplar trees, to develop biochemical tools for analysis of structural aspects of activity regulation of the RBOH enzymes involved in hypersensitive response of plants and to investigate a potential of the NADPH, a RBOH enzyme substrate, biosynthesis pathway modification to modulate ROS production and possibly to enhance the resistance of trees to environmental pollution.