RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'JOSEPHSON GATED TRANSISTORS AND ELECTRONICS' (JOGATE), addressing dissemination and exploitation.

assistant: **Impact**

Improving the energy efficiency of densely-integrated electronic is an important goal towards the sustainability of modern digitally-connected society, in particular for what concerns high-performance computing datacenters. An important piece of the solution is found in the contacts between metallic leads and the semiconducting channels that constitute the core of transistors, the key active component in integrated circuits. A significant part of increasing the energy efficiency is tied to managing the resistance that appears between metals and semiconductors: the contact resistance. In JOGATE we utilise the unique superconducting properties in hybrid superconductor-semiconductor components to uncover the mechanisms contributing to the contact resistance and thereby improve it. In doing so, not only we contribute to solving a major obstacle for the energy efficiency of established digital electronics, but we obtain the superconducting analogues to the conventional transistors and diodes. These superconducting components are unique in that they enable new avenues for superconducting circuit design, resulting in opportunities in miniaturisation, performance and cost of devices that find application in communication, sensing and detection, signal amplification and routing.In JOGATE we wish to study superconducting transistors and diodes and to upgrade their fabrication processes to be compatible with the methods of large-scale integration, making it possible for Europe to lead their industrial production. In parallel, we contribute to finding ways of improving their performance, to ease practical adoption and impact in areas ranging from cryogenic electronics to demanding environments such as space applications. Finally, to demonstrate the value of the technology and to de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'In vitro model of Fragile X Syndrome using naïve iPSCs' (NeuroStemX), addressing dissemination and exploitation.

assistant: **Impact**

Neurological and mental disorders are top priorities for the European Commission, which actively invests in research aimed at better understanding brain function and dysfunction, and at finding new therapies for brain disorders. Fragile X syndrome (FXS) is the major monogenetic cause for intellectual disability and is frequently associated with autism spectrum disorder. The trinucleotide repeat expansion, methylation and epigenetic silencing of fragile mental retardation 1 (FMR1) gene promoter leads to the loss of the corresponding protein. However, the molecular mechanism and the timing leading to FMR1 silencing are still unknown due to the absence of reliable in vivo and in vitro models. The recent development of naïve PSCs showing a broader unmethylated genome (including in FMR1) opened a new hope for disease modeling of FXS, but data are still partial and contradictory. The NeuroStemX project aims at filling this gap taking advantage of an optimized technique for the generation of naïve iPSCs developed at the University of Padova (UniPd) and generation of FXS neurons with various approaches mastered by the Experienced Researcher (ER) in conjunction with the microtechnologies developed by UniPd. In particular, we aim at 1) identifying the timing of FMRP silencing during neural development using naïve iPSCs and 2) establishing a reliable in vitro system to model neuronal defects observed in FXS patients. In this project, we are addressing some of the most crucial problems related with FXS pathogenesis and modeling using a variety of innovative approaches. This will give the ER an outstanding training-through-research opportunity by means of a personalized multidisciplinary project, in which the ER will enlarge her scientific competences and strengthen her professional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Defects in the tricarboxylic acid (KREBS) cycle genes in tumorigenesis'.

assistant: **Concept**

For this effort all top European cancer research groups working on the association between defects in the tricarboxylic acid cycle (TCAC) and cancer form a consortium to 1) profoundly characterize the human phenotypes to enable identification and efficient cancer prevention, and 2) to unravel the underlying molecular mechanisms. Recent breakthrough findings by the consortium participants and others have shown that defects in at least four TCAC genes - fumarate hydratase (FH, fumarase), and succinate dehydro genase (SDH) B, C, and D - can confer susceptibility to cancer. We shall take these studies forward by characterizing the natural history of the syndromes in large European materials. Simultaneously, we shall perform functional studies to elucidate the cel lular events induced by these defects by systems biology approaches including functional studies in cell lines, model organisms, and transcription profiling of TCAC deficient and proficient tumors and models. TCAC defect associated expression patterns will be utilized to examine other cancer types for such defects. We have evidence that modifying genes play a key role in TCAC defect associated tumorigenesis, and candidate regions have been identified. Following gene identification, the possible role of thes e modifiers in low penetrance cancer predisposition in the general population will be examined. The rationale to form this consortium is simple and strong. The consortium brings together the key European cancer researchers studying TCAC associated tumorige nesis. Studying separately the tumorigenic effects of FH and the different units of SDH would be ineffective, and formation of the consortium will ensure that Europe will maintain the initiative in this new and exciting field of research. The deliverables aris
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of Lgr6 as a marker of progenitor cells and cancer-initiating cells in the mammary gland' (Lgr6MammarySC) targeting Seventh Framework.

assistant: **Abstract**

The epithelial compartments of the mammary gland are thought to be derived from a tissue stem cell capable of self-renewal and differentiating into all cellular lineages of the mammary gland. Detailed studies of normal and tumorigenic breast stem cells have proven rather cumbersome since these cells are rare and a high degree of purification is needed.  Several approaches to isolate mammary stem cells are based on the use of relatively unspecific surface markers, which are also expressed on differentiated cells.Lgr5 is a marker of stem cells in several different organs, such as the intestine, the stomach and the skin. Recently, another Lgr family member, Lgr6, could be identified as a marker of a second epidermal stem cell population in the skin than can regenerate all cellular lineages of the skin.The high homology between Lgr5 and Lgr6 and the fact that both receptors represent stem cell markers in the skin, suggest that Lgr6 could also specifically mark certain stem cell populations in other tissues. Indeed, the host laboratory has found prominent expression of Lgr6 cells in brain, mammary gland and lung. Noteworthy, the hair follicle and the mammary gland are both ectodermal-derived appendages that show strong similarities as regards the molecular mechanisms controlling their formation, maintenance and cellular turn-over.Lgr6 shows a conserved upregulation between human and mouse mammary stem cell fractions. In line with the notion that normal stem cells can be a source of cancer stem cells,  breast cancer tissues shows an overexpression of Lgr6, similar to skin cancer cells.The first aim of the proposed project is to clarify the nature and identity of mammary gland cells that express the putative stem cell marker Lgr6.Secondly, this project will determine the funct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Clinical study in Parkinson's disease with two unique goals: 1) Proof-of-concept of CDNF protein for disease modification; 2) Validation of clinically tested device for intracerebral drug delivery' under Horizon 2020.

assistant: **Concept**

The main focus of TreatER is conducting a randomized, placebo-controlled, first-in-human, proof-of-concept, safety and efficacy study of intracerebrally administered CDNF protein therapy in patients with Parkinson’s disease (PD), using a neurosurgically implanted Drug Delivery System (DDS), which will also be clinically validated in the study. Thus the TreatER project has two independent goals, either of which alone can have significant impact addressing unmet clinical needs in chronic diseases, and advancing innovative European technologies:1) Proof-of-concept of CDNF protein therapy for disease modification in PD. The patented European innovation CDNF has further potential in other ER stress related indications.2) Clinical validation of DDS, an already clinically tested approach for accurately targeted intracerebral infusions in PD. The patented European innovation DDS has also significant potential in other indications needing intracerebral infusions.The clinical study builds on extensive preclinical research and related data on CDNF, including completed acute and chronic toxicology studies in non-human primates supporting an excellent safety profile. Further, the clinical study builds on existing clinical experience on DDS and related neurosurgery.Both conventional and novel means for assessing the efficacy of the treatment will be utilized. This requires strong interdisciplinary expertise and knowledge available in the consortium, including: Regulatory expertise in drug and medical device development; neurological and neurosurgical expertise in PD; PET imaging expertise specific to PD; Scientific expertise in novel neurotrophic factors, in specific CDNF; and GMP manufacturing expertise of novel biological drug compounds.Clinical trial applications are currently bei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Non-Hermitian Topological Physics in Grand Canonical Photon Lattices'.

assistant: **Objectives**

Topology is a powerful paradigm for the classification of phases of matter. One of its direct manifestations in the widely studied Hermitian systems, which are isolated from the environment, are robust states that emerge at the interfaces between matter with distinct topological order. Real systems, however, are never truly isolated from their surroundings and the influence of the environment on the topologically protected states remains to a large extent unknown. Even more importantly, understanding and controlling the openness of non-Hermitian systems can provide fundamentally new ways to create novel topological states of matter. TopoGrand will realise a new experimental platform to synthesise non-Hermitian topological materials. It will employ a room-temperature photonic platform combining nanostructured optical microcavities with a molecular medium, to achieve non-Hermitian topological lattices of photon condensates. The system will feature tuneable openness that is unique among other presently available experimental platforms: a controlled flux of excitations via spatially selective pumping and loss, energy dissipation at variable rates, and coherence modified by grand canonical reservoirs. New physics will be accessed in the course of this work: TopoGrand will demonstrate genuine non-Hermitian topological phases and edge states without a Hermitian counterpart. Specifically, we will test the emergence of interface states at a topological phase boundary and their robustness against lattice disorder, as well as reservoir-induced fluctuations. The project presents a completely new approach to topology, which will allow us to create reconfigurable photonic materials with topological protection simply by controlling the environment. With the novel toolbox, I will explo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Toward Desirable Metal Organic Framework Mixed Matrix Materials through Machine learning-guided Interface Design' to be submitted under Horizon Europe.

assistant: **Abstract**

Metal Organic Framework Mixed Matrix Materials (M4s) are prototyped for many applications such as separating membranes, drug delivery systems and fire-safe plastics. Like all composites, the premise of M4s is to achieve greater properties than those of their isolated components. Yet, the interface between the components determines whether the synergy between the components is achieved or the overall performance is diminished due to their incompatibility. In principle, the interface can be designed by selection and chemical modification of the components involved. However, in practice such design is a very challenging endeavor.  Atomistic simulations can predict the structure of the interface, from which the component compatibility may be inferred. Similarly, mechanical testing of the composites may reveal some qualitative characteristics of the interface. Nevertheless, the throughput of these approaches is insufficient to screen the design space for the optimal M4s for various applications. This project aims at developing the capability to computationally design M4s with good mechanical properties. By employing machine learning techniques, we will be able predict the properties of the interface in a high-throughput manner. Similarly, our multi-scale models will establish quantitative relationships between the interfaces and the mechanical properties of the composites, which can be verified experimentally. To achieve these objectives, the Researcher will be provided training-through-research in high-throughput atomistic simulation workflows, material informatics and machine learning for material discovery as well as homogenization techniques and finite element approaches for multi-scale modeling. Moreover, this project will give the Researcher an opportunity to apply her
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New European Bauhaus for All' to be submitted under Horizon Europe.

assistant: **Abstract**

The New European Bauhaus (NEB) brings the European Green Deal to life through inclusivity, aesthetics, and sustainability, evolving from grassroots efforts to impactful implementation. Central to this is the NEB Facility, which bridges research and innovation (R&I) with roll-out efforts, focusing on local neighbourhoods. NEB4All supports the Facility by strengthening a transnational network of Horizon Europe (HE) and Policy (POL) National Contact Points (NCPs), fostering collaboration, sharing best practices, and empowering NEB NCPs to deliver exceptional support to NEB Facility stakeholders.NEB4All unites 28 NCPs from 25 countries, combining the expertise of experienced and newly appointed members. Through tailored training, mentoring, and peer learning, it enhances NCP capacities, improving stakeholder support, increasing participation in NEB calls, and elevating proposal quality.Key objectives of NEB4All include:(1) Building NCP Capacity: Providing training and tools to align HE and POL NCPs and bridge knowledge gaps.(2) Raising Awareness: Equipping NCPs to engage national stakeholders and promote the NEB Facility effectively.(3) Improving Feedback Mechanisms: Creating systems to collect stakeholder insights and deliver actionable feedback to the European Commission.(4) Supporting Stakeholders: Empowering applicants through matchmaking events and stakeholder meetings.NEB4All lowers barriers to participation for stakeholders like municipalities, companies, researchers (from technical backgrounds and social sciences, humanities and arts), and civil society, fostering connections across the NEB ecosystem. By ensuring high-quality services and gathering actionable feedback, it enhances the NEB Facility’s visibility, accessibility, and impact, driving sustainable innovati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Think and Act', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The overall objective of Think and Act is the improved articulation between EC funded research in the Social Sciences and Humanities (SSH) and policy making at national, regional and local levels in the European Union. This objective will be reached through the diffusion and capitalisation of EC funded research in national and international contexts. A cycle of 5 conferences will be organised in 5 capital cities.The emphasis will be on the examination of international themes in national contexts through using research results from projects funded under FP4, FP5 and FP6, as well as appropriate actions funded by other sources (national or international). The conferences themes will be: In Paris, Governance and Democracy" in Roma, "Citizenships and Identity" in Budapest, "Gender issues in the light of the enlargement" in Istanbul, "Challenges to EU enlargement and border issues" in Madrid, "Social cohesion". Press conferences and a large media cover will be set up."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Design of NanoMOFs Capsules for Drug Delivery and Bioimaging.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Cancer is a major health problem worldwide, being the most common cause of death after cardiovascular diseases. The major goal of new anticancer therapies is to specifically kill tumour cells while leaving healthy cells unharmed. A main challenge to achieve this aim is the development of better drugs, including novel treatments based on the use of siRNAs. These macromolecules are potentially the most powerful anti-cancer drugs that exist, but still there is no efficient way of getting them delivered specifically to the tumour. Indeed, lifetime of such molecules is generally too short and therefore need to be protected in a carrier until they are delivered into tumour target cells.This project focuses in the development of nanocarriers based on metal-organic frameworks (MOFs), one of the most exciting developments in recent porous materials science. The study of the mechanisms that control drug delivery is of critical importance to nanomedicine applications, where nanotechnology has the potential to revolutionise cancer therapy. Given the challenging nature of the drug delivery problem for cancer therapy, this project builds on 4 interrelated main concepts: i) the design of bio-compatible MOFs for drug delivery applications; ii) the post-synthesis engineering of MOFs to enhance stability, controlled drug release, and targeting; iii) the identification of optimal textural properties (i.e. pore size distribution, surface area, pore volume) and surface chemistry of MOFs for siRNA delivery using experiments and molecular simulation techniques; iv) the assessment of their performance in vitro and in vivo, giving a translational dimension to the proposed research. The novelty of this work lies therefore in the synergistic combination of tools from different areas and disciplin