RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enzyme-based detection bio-sensor' in the context of a Fifth Framework call.

assistant: **Objectives**

EN.BIOS Exploratory Phase proposal objective is the development, testing and validation of an advanced biosensor device, using enzymes as detection element and an electrochemical system as transducer. EN.BIOS. will permit the detection in various matrices (fruit juice, dairy products, wine, etc.) of specific food components such as: sugars, alcohol, organic acids, stabiliser, antioxidant. The following activities will be carried out:- development and testing in various matrices of a sensor laboratory prototype;- development of simple analytical procedures to measure compounds through the bio-sensor according to end-users specifications;-validation of the implemented bio-sensor and the relative analytical procedures for the determination of specific compounds through consolidated traditional methods in artificial and real samples;- testing of the validated bio-sensor by end-users operating in different sectors in the agro-industrial field (fruit juices, wine, dairy) for a feed-back process to optimise and diffuse the technology;- economic and technical feasibility analysis to assess a large scale production potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'valiDation of Radical Engine Architecture systeMs' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Since the publication of the ACARE goals, the commercial and political pressure to reduce CO2 has increased considerably. DREAM is the response of the aero-engine community to this pressure. The first major DREAM objective is to design, integrate and validate new engine concepts based on open rotor contra-rotating architectures to reduce fuel consumption and CO2 emissions 7% beyond the ACARE 2020 objectives. Open rotors are noisier than equivalent high bypass ratio turbofan engines, therefore it is necessary to provide solutions that will meet noise ICAO certification standards. The second major DREAM objective is a 3dB noise emission reduction per operation point for the engine alone compared to the Year 2000 engine reference. These breakthroughs will be achieved by designing and rig testing: – Innovative engine concepts – a geared and a direct drive contra-rotating open rotor (unducted propulsion system) – Enabling architectures with novel active and passive engine systems to reduce vibrations These technologies will support the development of future open rotor engines but also more traditional ducted turbofan engines. DREAM will also develop specifications for alternative fuels for aero-engines and then characterise, assess and test several potential fuels. This will be followed by a demonstration that the selected fuels can be used in aero-engines. The DREAM technologies will then be integrated and the engine concepts together with alternative fuels usage assessed through an enhanced version of the TERA tool developed in VITAL and NEWAC. DREAM is led by Rolls-Royce and is made of 47 partners from 13 countries, providing the best expertise and capability from the EU aeronautics industry and Russia. DREAM will mature technologies that offer the potential to go beyond
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'European Network for integrated TRAINing on Innovative Therapies for VISion RestoratiON'.

assistant: **Innovation**

Blindness is the most feared handicap leading to the greatest exclusion from society by reducing patient autonomy and mobility. There are still an estimated 39 million blind people worldwide. Clinical trials have demonstrated the possibility to regain some useful vision with retinal prostheses in patients having lost photoreceptors. New approaches are entering into clinical trials such as photovoltaic implants, optogenetic therapy and even cortical prostheses for patients having lost eye to brain connection. In the present ENTRAIN-Vision project, the Early Stage Researchers (ESRs) will work on these innovative technologies for restoring vision in blind patients. Their training in academic institutes or industry will be completed by several secondments, including one at an industry partner. In addition, several winter/summer schools will address scientific subjects on vision restoration and transferable skills in technology transfer, clinical trials, start-up creation, communication to media. Lectures will be followed by practice e.g. innovative technologies for assessing brain function. The project will thus create a unique European network of researchers, clinicians and industrials on visual restoration. This network will provide a comprehensive training across multiple disciplines including neuroscience, vision, psychophysics, genetic, electronic, bio-engineering and computational modelling. It will therefore prepare a new generation of leaders able to carry the new therapeutic strategies from bench to patients. ESRs will encounter founders of start-up and industrial partners enlarging thereby job opportunities to 1) remain in the career path of research & innovation, 2) contribute to clinical trials and/or develop the rehabilitation programs or 3) get involved in pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Strategic Climate Litigation’s Direct and Indirect Consequences for Democracies' (LitDem).

assistant: **Innovation**

Sharply increasing strategic climate litigation (SCL) is a legal and social fact. It has the potential to influence the democratic process at a time when democracy and its safeguards are already widely in decline. As other strategic litigation, climate litigation involves many actors (NGOs; media; politicians) and has many nuanced and indirect consequences beyond its direct legal effects (creating authoritative legal narratives, framing perceptions, fostering cooperation, and ‘legalising’ the political debate). However, because of the particular nature of the climate emergency, as a global, scientifically certain existential threat to humanity, SCL is an extreme case of strategic litigation, both in quantity and in quality. As a sharply growing phenomenon, it aims for socioeconomic changes in response to the climate emergency as (1) a truly global collective action problem; which is (2) increased by structurally inadequate political responses; and (3) affects those most, who do not (yet) have political power. It is also distinct in its reliance on (4) arguments based on non-binding international norms (e.g., in the Paris Agreement) and (5) complex science with uncertain legal effects (litigants: climate science; defendants: carbon capture technology).LitDem breaks new ground by providing the missing theoretical framework that captures not only the direct legal but also the indirect non-legal consequences of SCL for the democratic process in times of societal tensions and democratic decline. It provides greatly needed guidance to involved actors. Based on qualitative multi-method studies (incl. systematic content analysis, doctrinal analysis, interviews) of all SCL in 4 national and 2 European jurisdictions (DE, FR, NL, UK, EU, ECHR), it offers a grounded conceptual unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Inpainting-based Compression of Visual Data' in the context of a Horizon 2020 call.

assistant: **Objectives**

Generating huge amounts of visual data, be it images or videos, has never been easier than today. This creates a growing demand for lossy codecs (coders and decoders) that produce visually convincing results also for very high compression rates. Popular transform-based codecs such as JPEG and JPEG 2000 have reached a state where one cannot expect significant improvements anymore. To go beyond their limitations, fundamentally different ideas are needed.Inpainting-based codecs can change this situation. They store only a small, carefully optimised part of the data. In the decoding step, the missing information is filled in with a suitable inpainting mechanism. A successful realisation of inpainting-based codecs can offer decisive advantages over transform-based codecs: The stored information is more intuitive and closer to the mechanisms of human perception. Moreover, the concept is very flexible: It allows to integrate a number of different features and can be tailored towards dedicated applications. Most importantly, the higher the compression rate, the larger are the qualitative advantages over transform-based codecs. However, the potential of these codecs is widely unexplored so far, since difficult fundamental problems must be solved first. This includes optimisation of the data and the inpainting process, sophisticated data coding, and the design of real-time capable sequential and parallel numerical algorithms. We are committed to addressing all these challenges in an integrated approach: We cover the entire spectrum from its theoretical foundations over benchmarking and highly efficient numerical algorithms to codecs for specific applications, and a real-time 4K video player as demonstrator. This will lift inpainting methods from a visually pleasant image editing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Three Research Infrastructures together: Carbon Uptake Southern Ocean'.

assistant: **Innovation**

The ocean is key in the global C cycle, taking up ca. 25% of the CO2 we emit, slowing climate change and giving us more time to mitigate and adapt to climate change. The Ocean C Value Chain (VC) of observations, data QC & analysis delivers key information around this to decision makers such as the Conference of the Parties. The RIs play a pivotal role in the VC via their ability to operate at scale & pool resources to ensure common data standards and operational practices. The urgency of the climate crisis drives us to put this VC on a much more robust footing with the World Meteorological Organisation leading the planning of a Global Greenhouse Gas Watch (G3W) covering all components of the Earth System. Unfortunately the VC currently delivers estimates of Ocean C uptake much larger than those from models, leading to a damaged ability to manage climate change. However further work suggests that observations at a much higher density in the Southern Ocean (SO) would substantially resolve this issue. Our ability to deliver these via ships is limited by the small number that enter the SO and we therefore need many more observations from research vessels, citizen science platforms, autonomous robotic floats & surface platforms. This step change requires substantial technological innovation and complex data synthesis. TRICUSO will address these needs by a) improving the sensing technologies on floats and small uncrewed surface vessels, b) supporting citizen science on yachts and potentially cruise and expedition vessels, c) integrating biological observations into the work flow, d) improving data flows to scientists, e) evaluating the density of observations needed & f) proposing fit for purpose governance structures that allow the RIs to operate within the G3W. These action
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced industrial gas turbines - development of transonic cooled stages for high pressure ratios through innovative design, manufacturing and testing techniques' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

For industrial, land based gas turbines with power ranging from 1 to 40 MW, the market trend is towards higher and higher efficiency at constant and possibly decreasing costs per kW shaft power. Higher efficiencies can be achieved with advanced 3-D aerodynamic design techniques and with the increase in the maximum cycle temperatures associated with advanced cooling techniques and hot part materials. These latter however imply substantial increases in the manufacturing costs, therefore, it is necessary to reduce the number of stages, especially in the turbine hot sections. The main aim of the project is to provide significantly higher efficiency than current technology will allow for, while at the same time reducing the manufacturing costs through the use of a lower number of components. To achieve this goal it is required to: - Iimit the number of turbine stages to two for a single-spool machine; - make the aerodynamic design suitable for pressure ratios in the order of 18:1 to 20: 1; - design the high Mach number (1.4), high pressure ratio blading suitable to provide very high aerodynamic expansion efficiency (of the order of 92 %), but within stress and metal temperature constraints suitable to assure reliability and long life. These requirements imply the use of transonic stages with associated problems of cooling effectiveness if conventional cooling techniques are used Accordingly, a novel cooling system applicable to transonic stages will be developed requiring also the development of a specific manufacturing technology since, convergent slits with negative taper of the hole exit are required. The development of high load transonic stages is a challenging task, requiring the availability of development techniques beyond the present state-of-the-art Accordingly, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of a HIV Candidate Vaccine for Phase I and II Clinical Trials in China' (1994-1998).

assistant: **Innovation**

* To create a basis for testing HIV candidate vaccines in clinical phase 1/2 trials* To develop a novel HIV-candidate vaccine on the basis of regional virus strains* To assess the safety, immunogenicity and efficacy of the proposed candidate vaccine in a relevant primate modelExpected OutcomeIt is expected, that this project will lead to a close collaboration between the European and Chinese partners in the area of epidemiology and vaccine development. Furthermore, this study will contribute to the molecular characterization of the prevalent B1- and C-clade HIV strains from South-East Asia, which will be subsequently utilized for the construction of an innovative VLP and DNA based antigen-delivery system. A systematic evaluation of these candidate vaccines with respect to their safety, immunogenicity and efficacy is considered to be an essential prerequisite in order to proceed to further clinical trial phases.* Careful monitoring of the epidemic situation in a given population is one of the important issues in preparing clinical phase 1/2 trials. Due to the very recent outbreak of the HIV epidemy in the rural population in the Dehong prefecture of Yunnan, the variability of the virus in this area seems to be still restricted to a HIV-1 B1-Thai subtype. However, the antigenic drift will be carefully monitored by the Chinese Academy of Preventive Medicine (CAPM) and the Health and Epidemic prevention stations (HEPS) assisted by the Institute of Medical Microbiology and Hygiene (RIMMH, Germany).* In order to optimize the chances of a successful vaccine, recombinant virus-like particles and a corresponding DNA vaccine will be constructed based on a careful molecular characterization of prevalent B1-(Thai) and C-clade HIV strains of the endemic areas in China (CAPM).* The l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Establishing traceability for cod (Gadus morhua): determining location of spawning and harvest' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Our project will develop the methodology to establish the origin of cod. We will first optimise techniques that can be used to determine the location of spawning and of harvest of individual cod during different times of the year. Next, we will test the permanence of spawning and harvest markers using transplantation experiments between countries. A double-blind experimental design will next be used on a collection of wild and farm-reared cod from the major EU basins to define the limits at which our techniques are useful for traceability.Finally, we will place our findings in a user-friendly format for potential end-users in the EU community (Fisheries Managers, Seafood wholesalers, and others). This will involve synthesising our findings with EU Common Fisheries Policy and law, running a cost-benefit analysis, and presenting the results a dedicated forum our methods could then be quickly transferred to other targeted species in EU waters. Objectives will be achieved through a three-year R&D project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Modulating cellular clearance to cure human disease' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Cellular clearance is a fundamental process required by all cells in all species. Important physiological processes, such as aging, and pathological mechanisms, such as neurodegeneration, are strictly dependent on cellular clearance. In eukaryotes, most of the cellular clearing processes occur in a specialized organelle, the lysosome. This project is based on a recent discovery, made in our laboratory, of a gene network, which we have named CLEAR, that controls lysosomal biogenesis and function and regulates cellular clearance. The specific goals of the project are: 1) the comprehensive characterization of the mechanisms underlying the CLEAR network, 2) the thorough understanding of CLEAR physiological function at the cellular and organism levels, 3) the development of strategies and tools to modulate cellular clearance, and 4) the implementation of proof-of-principle therapeutic studies based on the activation of the CLEAR network in murine models of human lysosomal storage disorders and of neurodegenerative diseases, such as Alzheimers s and Huntington s diseases. A combination of genomics, bioinformatics, systems biology, chemical genomics, cell biology, and mouse genetics approaches will be used to achieve these goals. Our goal is to develop tools to modulate cellular clearance and to use such tools to develop therapies to cure human disease. The potential medical relevance of this project is very high, particularly in the field of neurodegenerative disease. Therapies that prevent, ameliorate or delay neurodegeneration in these diseases would have a huge impact on human health.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'An automated platform for the large-scale production of miniaturized neuromuscular organoids' in the context of a Horizon Europe call.

assistant: **Objectives**

Organoids have been developed as advanced 3D cell culture systems that resemble aspects of the in vivo tissues and provide an alternative to study the mechanisms of human disease and identify novel treatments. The last years have witnessed tremendous developments in the field of stem cell and organoid research, but the full potential of these systems remains to be exploited. Two major challenges facing the organoid field are reproducibility and scalability. The manual production of organoids is a labor-intensive and expensive process. The development of cost-effective, fast, and reliable methods is a prerequisite for transferring organoid technologies to the industry for high-throughput approaches. We have recently established a novel complex human neuromuscular organoid (NMO) model from human pluripotent stem cell-derived neuromesodermal progenitors. NMOs self-organize into spinal cord neurons and skeletal muscle compartments that contract by forming functional neuromuscular junctions. The ERC consolidator grant “GPSorganoids” focuses on the generation of position-specific (GPS) NMOs representing distinct spinal cord segments and the use of such NMOs models to study the selective vulnerability of specific spinal cord neurons to neuromuscular diseases like amyotrophic lateral sclerosis and spinal muscular atrophy. The PoC grant goes beyond the scope of our ERC consolidator grant and focuses on the commercialization of the NMO model through the establishment of an automated, reliable, and high throughput production line that could apply to industry settings. Our ultimate goal is to establish NMOs as a leading model in the market for high throughput drug screening approaches and accelerate the development of novel therapies for neuromuscular disorders.