RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Semidefinite and robust optimization and their economic applications' (SAROTEA).

assistant: **Innovation**

Robustness to modeling and estimation errors is an issue of critical importance for financial optimization problems because of the serious consequences of making wrong bets. Surprisingly, however, robust optimization has not been widely explored in financi al engineering. The research proposed here formulates robust dynamical models for financial problems and develops semidefmite programming (SDP) based methods for solving them. These models systematically account for parameter uncertainty and robustly updat e error-bounds as more information becomes available over time. In addition, this research extends the semidefmite relaxation methodology to probabilistically robust optimization problems that naturally emerge in the financial context. The other research f ocus of this proposal is on developing semidefmite models for graph theoretic problems such as the traveling salesman problem and network design. These models employ linear matrix inequalities (LMI) to represent 'geometric' constraints, such as graph conne ctivity, specified number of edge/vertex disjoint paths, etc. The optimization problems resulting from these LMI models are, typically, mixed integer semidefmite programs,Currently, mixed semidefmite programs are approximately solved by relaxing the integr ality constraints. However, as computational power increases and the interior point methods for solving semidefmite programs become more efficient, there grows a trend for developing systematic methods of tightening the relaxations - as in the case of line ar programming relaxations of mixed integer programs. As a first step in this direction, I propose to develop several cutting plane strategies for mixed semidefmite programs. Although the problems of interest belong to various application areas, they are l i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New gallium phosphide grown by vertical gradient freeze method for light emitting diodes' in the context of a Fifth Framework call.

assistant: **Objectives**

The main objective is the development of better & cheaper gallium phosphide (GaP) substrate for manufacturing of light emitting diodes (LED's). The definition of the objective is coming from an indispensable role of LED's in modern information society by delivering visual information to citizen-user.To accomplish this goal the main objective is divided into several partial objectives: development of GaP with small quantity of structural defects grown with modern vertical gradient freeze method; manufacturing of GaP substrates; validation of substrate parameters by manufacturing and application-like testing of LED's prototypes. The ultimate objective is to prepare a route for manufacturing of GaP substrate in EU as an alternative of GaP substrates supply for LED's producers because there is no such production place in EU and NAS.Work description:The work in frame of project will be realized in a stages as follows:1) Target scheme for the project goals and their assessment, will be produced by following permanent market analysis and consulting experts;2) An apparatus for sophisticated VGF technology will be designed and manufactured. The equipment will provide precise and stable temperature gradient for the processed materials, while this gradient will be controllable via PLC (Programmable Logic Controllers) and will be moving along the ingot axis during the crystal growth. The whole polycrystalline and single crystal processes will be realized at the 40 - 70 bar pressure to prevent any dissociation. The work will include technology development of 50 mm to 70 mm diameter crystals;3) The implementation of more less known semiconductor wafer technology for the production of VGF GaP substrates. This work shall be broadened out to include a design for specialty multi-blade sa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'An integrated methodological approach to structural studies on complexes of GTP-binding proteins with their effectors and regulators and design of new molecules' under Fourth Framework.

assistant: **Concept**

The project concerns the elucidation of the structures of complexes of Ras-related GTP-binding proteins with their effectors and regulators. It is a multi-disciplinary, multi-national approach which brings together biochemists, NMR spectroscopists, X-ray crystallographers and modellers all of which are crucial for an efficient structural biology programme. The network intends to develop methods for the identification and recombinant expression of proteins, for the NMR spectroscopy of larger proteins and complexes and for combining NMR spectroscopy with X-ray crystallography. These methods will be applied to identify and express complexes of Ras, Ral, Rap, Rac and Rho and to solve their three-dimensional structures by NMR and X-ray crystallography. The structural data will be used for the analysis of the protein-protein interfaces and to derive common principles. The structural, biochemical and biophysical results will aid in the understanding of the function of Ras-related switch proteins and the signalling cascades they control. It will also lead to an understanding of the specificity of these processes at the atomic level. The structural analysis of the protein-protein interactions will lead to the design of new types of GTP-binding proteins and their partners which can be analysed in the cell. It will also provide a structural basis for the design and/or improvement of drugs directed against the function of these proteins, since they are involved in the control of number of diseases. The knowledge obtained will also be used to screen for hitherto unknown interacting molecules in the databases of large-scale sequencing projects. Finally, the development of NMR techniques will be incorporated into software packages that are sold by the commercial participant of the net
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Laser surface treatment for extended lifetime of parts for combustion engines, tools for sheetmetal working and small machine parts'.

assistant: **Objectives**

The aim of this project is to develop a production technology employing Laser alloying and Laser cladding for achieving extended lifetime of machine parts, tools for sheetmetal working and parts for combustion engines. Machine parts and tools that are subjected to cyclic mechanical and/or thermal loads and that are operated under corrosive, erosive and/or aggressive conditions exhibit a restricted lifetime. These operational conditions cause wear and corrosion attack and lead to direct costs for instance for repair and to indirect costs for instance by stagnation of production. For some of these parts and tools Laser surface treatment is the best way to a higher productivity. Laser surface treatment of critical sites of components gives specific surface properties witllout distortion of adjacent material. Laser hardening and remelting are common treatments, whereas Laser alloying and Laser cladding are relatively new possibilities. Basic research has given an indication about the technological possibilities of these surface treatments. However, additional research and development is necessary before this new production tool can be used in practice, especially in small enterprises. Particularly an investigation of the combination of Laser beam conditions, surface conditions of the workpiece and clad material must lead to a method of surface treatment of high reliability and products with a large lifetime. Subsequently further development and exploitation can be done by the participating small enterprises themselves. The advantage for the participating companies is that as a result of this project they get entrance to Laser technology that can be performed by industrial suppliers. Since Laser technology is a new technology the industrial Laser treatment companies are almo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Treatment of late onset bacterial sepsis caused by vancomycin susceptible bacteria in neonates and infants aged under three months' (NEOVANC).

assistant: **Innovation**

Vancomycin is the critically important antibiotic to treat neonatal Late Onset Sepsis (LOS) due to Gram positive bacteria in neonates, including Coagulase Negative Staphylococci (CoNS) and Staphylococcus aureus. These organisms also create biofilms which are extremely resistant to antibiotics. The increased incidence of LOS due to bacteria such as CoNS and MRSA in NICUs has led to a marked increased use of vancomycin, which is now the third commonest antibiotic used in European NICUs. However, a standardised dosing regimen for premature infants has not yet been defined and there is no data about the serum concentrations needed to ensure bacterial kill for CoNS in humans. In view of the lack of any firm dosage for neonates and infants, vancomycin has been included in the EMA list of off-patent drugs addressing unmet therapeutic needs in children. Accordingly NeoVanc consortium has already submitted a Paediatric Investigation Plan (PIP) which has provisionally received a favourable 120 day opinion and this application is built on what is included in the approved  PIP. This project aims to:-develop a new age-appropriate formulation of vancomycin; define the circulating concentration of vancomycin that is needed to kill CoNS in in vitro biofilm and animal model, and use that data to derive the concentration and best PD target that will be maximally effective in neonates; define the neonatal dosage that is needed to attain the concentration that can kill CoNS and enterococci by conducting a systematic meta-analysis of all available PK data and develop an optimal dosing and therapeutic drug monitoring regimen. NeoVanc will then conduct a Phase 2 b randomised clinical trial to compare the proportion of neonates reaching the PD target derived from the pre-clinical studies when
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Revolutionizing Olefin Production with the electric High Mach Steam Cracking Reactor', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Power to heat (P2H) is expected to be the first type of electrification that will drastically transform the chemical industry. This holds in particular for producing its major building blocks: the 300 Mt/yr light olefins via steam cracking at more than 800°C. e-CRACKER will implement P2H by so-called shockwave heating, enabling an increase in temperature to >1000°C in 10 ms, an order of magnitude faster than the current furnace-based technology in a revolutionary High-Mach reactor. When combined with insight in the pressure-dependence of the cracking chemistry this will allow to avoid undesired side reactions and to increase olefin yields of ethane and plastic waste derived naphtha cracking by 10 wt.% compared to yield gains of 0.1 wt.%, at best, when applying alternative P2H such as resistive heating. e-CRACKER will:     1. generate new fundamental understanding of shock wave heating and kinetics under sub- and supersonic conditions;     2. demonstrate the practical applicability of an open-source, high fidelity Multiscale Modeling platform in combination with finite rate chemistry for turbulent reacting and rotating flows;     3. develop a compact, energy-efficient, electrified High-Mach reactor generating shockwaves and minimizing side products by avoiding back-mixing;     4. pave the way to avoid more than 200 Mt CO2/yr emissions with a scalable, flexible, step-by-step implementable technology driven by renewable electricity. Starting from fundamental local and global (non-)reactive data collection (WP1), and a high-fidelity open source Multiscale Modeling framework (WP2) novel 3D reactors will be designed in silico using advanced optimization (WP3). The power of the approach will be demonstrated in a 3D-printed High-Mach reactor, which, by operating under unconvent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel organic-inorganic materials in opto-electronic systems for the monitoring and control of bio-processes' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Biotechnological processes can be found in food, drink and pharmaceutical industries, waste processing or environmental protection and they need affordable and rapid sensing techniques. MATINOES is aimed in the development of novel enzyme based fibre optic sensors for applications in biotechnological production processes to cover the lack of sensors suitable for in-situ, continuous monitoring of reactants under harsh reaction conditions. The partnership has 9 partners from 5 different countries. It contains internationally recognised specialists in: inorganic-organic coating materials, enzyme preparation, enzymatic reactions, design and preparation of optical fibres, and sensor design. The project also involves SMEs involved in the design and supply of biochemical plants and instrumentation, and the manufacture of fibre-optic instrumentation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A novel systems biology approach to develop preclinical assets from innovative drug discovery starting points inspired by viruses' (MIMESIS), addressing dissemination and exploitation.

assistant: **Impact**

Access to new medicines targeting unmet medical need is a challenge for both the Pharmaceutical industry and the member states of the European union. For the last decade the pharmaceutical sector has faced fundamental dilemmas:- The average cost to develop a single drug has tripled in a decade- Patent expirations have reduced revenue from blockbuster drugs- Attrition in the drug development pipeline remains high. - The rate of innovation in pharmaceutical development is low because of a focus on a restricted number of drug target classes and emphasis on developing “me-too” drugs. In this context, ENYO has developed an innovative systems biology based approach inspired by viruses to identify patentable chemistries directed at new human disease targets. The feasibility of this approach has been successfully demonstrated in 2015 with the identification of 40 largely unexplored novel human targets against influenza virus, which eventually resulted in the generation of leads ready for development as a therapeutic for influenza.Project MIMESIS aims to scale-up ENYO’s systems biology approach to discover original preclinical assets against human targets not previously considered tractable to drug development in both infectious (Influenza, HRV, RSV, TB and Zika) and non-infectious disease contexts (Oncology).  It will scale-up the number of drug discovery targets and the disease scope and initiate the deployment of the approach to the pharmaceutical industry at the global scale. The MIMESIS approach will develop novel starting points for the development of new drugs in diseases with unmet clinical need. It will contribute to better access to medicines which will translate into higher pharmaceutical benefit to the patients. The approach has never been used before in the pharmace
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Conceptualization and operationalization of minorities in the practice of UN treaty bodies' (MINCOOP), addressing dissemination and exploitation.

assistant: **Impact**

MINCOOP is an interdisciplinary and intersectoral project that focuses on the conceptualization and operationalization of minorities under universal international law, with the ultimate purpose to improve the legal protection of traditional (national, ethnic, religious, linguistic) minorities and persons belonging to them. The project contributes to a growing area of minority studies, setting out from the recognition that international law routinely operates with the concept of minority when providing standards for the recognition of group-specific rights or protection from discrimination, without actually offering definitions on the protected groups (conceptualization) or membership criteria therein (operationalization). This in not merely an unresolved theoretical issue, but a practical deficiency with crucial importance for the protection of minorities. Namely, ambiguity in the relevant terms hampers the achievement of policy goals, and the potential for abuse easily leads to further discrimination and marginalization. In order to give definite answers to the problems of conceptualization and operationalization, the project proposes to carry out an up-to-date, systematic and comparative analysis of the monitoring materials of the ten UN human rights treaty bodies  thus filling an important gap in scholarship. The project follows a mixed-method research design including quantitative, computer-assisted content analysis and qualitative legal analysis, as well as case studies and field research (interviews) conducted in Slovenia. The research project will not only inform the theoretical debate on minority rights and provide recommendations for policy-making, but also intends to raise awareness of the pressing issues of traditional minorities among the general public, pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards a connected history of population, environmental change, capital and conflict in Russian Eurasia, 1860s-1920s' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Land Limits is a ground-breaking environmental history that explores the ecological impact of population growth in Eurasia, from the emancipation of the serfs in 1861 to the close of the civil war in the early 1920s: a period of unprecedented mobility and demographic flux. It redefines the field of late imperial Russian and early Soviet history by challenging assumptions that in a sparsely populated political territory stretching across a sixth of the worlds surface, population pressures occurred only in the agrarian provinces of what was then European Russia. Instead, it proposes relocating to the empires borderlands, and conceptualizing the empire as multiple geographically-disparate but ecologically-interconnected regions: an innovative method of analysing a political entity that usually resists holistic critical enquiry. Via a programme of nuanced, critical historical research conducted in libraries and archives across five nation states, the project seeks to understand both intellectual and material dimensions of the relationship between population pressure and anthropogenic environmental change, and then interrogates the implications of these ecological shifts. It suggests that as increased populations created changes in land use and resource exploitation, so these new patterns became both the motor of economic growth via local, national and global networks of labour, capital and commodities, and the fulcrum around which various forms of conflict emerged, as land and resources became limited, contested and politicised. These were vital forces that transformed borderlands and became key factors in the violent collapse of the empire and the evolution of the early Soviet state. In doing so, the project redefines scholarly debates on the nature of economic growth and