RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'REPRESSIT: A novel class of clinical immune checkpoint inhibitors' (REPRESSIT) targeting Horizon Europe.

assistant: **Abstract**

In the tumor microenvironment, continuous or “tonic” stimulation of T cells induces checkpoint signaling through inhibitory immune receptors (IRs). This phenomenon suppresses T cell function, contributing to an exhaustion phenotype and their consequent failure to eliminate cancer cells. Checkpoint blockade through IR-targeting antibodies (e.g. anti-PD-1, anti-CTLA-4) can partially reverse this process, and has revolutionized cancer immunotherapy. However, a large fraction of patients, e.g. with tumors that do not express IR ligands, do not benefit from this treatment. Thus, a large unmet need remains to be addressed.We aim to change the current ligand-centric “blockade” paradigm. The REPRESSIT platform technology developed herein will provide a radically new approach, through development of a novel class of ligand-independent checkpoint therapeutics. These Receptor Inhibition by Phosphatase Recruitment (RIPR) molecules recruit tyrosine phosphatases to the IR and shut down IR signaling, thereby reactivating exhausted T or NK cells to effectively clear cancer cells.The REPRESSIT consortium unites unique complementary expertise and models in IR biology, tumor immunology, protein engineering, biophysics and proteomics, to: 1) define the design principles of RIPR molecules against multiple checkpoint IR targets, 2) evaluate the IR mode of action of signal inhibition, 3) optimize RIPR molecule for their efficacy using preclinical cancer models, and 4) demonstrate in vivo proof-of-concept (PoC)), focusing on a highly-relevant panel of T and NK cell IRs known to display tonic signaling.REPRESSIT will deliver a technology platform for off-the-shelf RIPR designs targeting phosphotyrosine-carrying IR. This project will provide the foundation for our long-term vision of innovative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Effect of an External Electric Field on Grain Boundary Evolution in the Course of Nano-Ceramic Sintering' under Seventh Framework.

assistant: **Concept**

Consolidation of oxide nanoparticles in the presence of an electric field has provided promising results for retaining the nanostructure in the bulk. Although the sintering of nanoparticles shares the same basic principles as those for the sintering of coarser particles, a number of issues and challenges are specific to nanosintering. From a thermodynamic point of view, solid state sintering can be described as a thermally activated process during which the total interfacial free energy of an assembly of particles of equilibrium chemical composition decreases. Moreover, the consolidation and the grain growth pattern are determined by the ratio of the solid-vapour interfacial energy to the solid-solid interfacial (i.e., grain boundary) energy of the material. We propose to take a first step towards elucidating these processes in the presence of an external electric field by testing the synergistic effects of an external electric field and dopants on the grain boundary energy and sintering mechanism of oxide nanoceramics. Our first objective is to study the individual contribution of the dopant on the surface and interfacial energies. We hypothesize that the dopant will significantly affect these energies and thereby change the sintering course. Our second objective is to study the effect of a DC electric field on the dopants, the interfacial and surface energies, the space charge layer, and the grain size of the materials. We will map the contribution of each parameter to the consolidation process. The most promising parameter will be further investigated by studying the properties of the resulting material which is the third objective of this study. The experiments proposed here will increase our understanding of the consolidation mechanism of nanoceramics in the presen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Executive career advancement' under Sixth Framework.

assistant: **Concept**

The first objective of the project is to create high-impact publications of the three working papers that the Researcher started to work on as a doctoral student at the Wharton School of the University of Pennsylvania. All three papers address the individual-level and organizational factors that facilitate executives' advancement to the top of corporate hierarchies. The process of working on subsequent revisions necessitates close cooperation between the Researcher's doctoral institution and the Researcher.The second objective is to expand this research to a European context and examine the predictors of executive career advancement on a sample of Spanish executives. Phase 1 of this project will look at five types of corporate career development practices and will link these practices to a much more comprehensive set of organizational characteristics (the organization's total income, EBITDA, personnel costs, industry affiliation, human resource management practices, etc.) than it was done previously. In Phase 2, the Researcher will collect biographical information on the executives who are at the helm of the organizations sampled in Phase 1.The third objective is to develop a 15-session elective course on executive career advancement based on the research outlined under Objectives 1 and 2, for international MBA students at the Host Institution. A similar course is not offered at most business schools and will require considerable intellectual input from the Researcher. Each academic year, this elective course will be offered twice. The preparation of the course will also include the production of a syllabus and teaching materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Wooden Architecture: traditional Karelian Timber Architecture and Landscape' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The Karelian wooden architecture is recognized as an object of treat peculiarity and interest on an international scale. The study days are addressed to the universities and the institutions involved into the project and they set the promotion of research activities launched in this country as a target. The aim of the operation is to encourage the relations, not only the cultural ones, between Italy, Finland, Karelia bringing into contact operators of this field through a threading of meetings of which the present represents one of the first opportunities. The gained scientific experiences about topics liked to the recovery, the rehabilitation and the improvement of historical centres, with intensive activities of research and analyse, produced a know-how which is highly valuable at the present moment; especially for the use of specific applications of the new technologies, for the monitoring and for the data-management useful for the restoration, the urban planning and management in sensitive areas, like urban centres of historical and environmental interest. In particular the Karelian territory is configured as a dense area of elements which need a high attention in order to crease the value of the territory itself and its anthropic activities. The objective of a census of the traditional wooden architecture and natural environment and landscaping purposes is to determine not only the species and appearance but also the analysis of damages and the conditions, for identifying critical management factors. The census defines the landscaping and environmental aspects, as well as the diagnostic picture of each context on the basis of its intrinsic characteristics, possible untraditional elements, and finding the way to restablished the correct structure of the place. We ar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A tool box to catalyze continuous process INNOvation within the TEXtile manufacturing lines in Europe', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Within a European Collective Research involving 26 partners from seven countries (six textile professional associations from Belgium, Portugal, Italy, Spain, Hungary, Poland and the European Apparel and Textile Organisation EURATEX, 10 SMEs and 9 RTD performers) the main objective of the INNOTEX project consists in developing and disseminating a productivity enhancement tool box for the textile industry. It aims at supporting process improvement primarily in ISO certified European textile SMEs, where continuous process innovation will lead to both productivity gains and quality increase of the final textile products. Performance indicators of four key textile processes will be mathematically modelled : - polymer extrusion/yarn manufacturing - dyeing - finishing - technical fabrics manufacturing. This tool will be made interoperable with other available ERP solutions, thus responding to legacy issues for ERP systems already in place in textile SMEs. An accompanying training tool aiming at gathering process data, and at using the above self learning software techniques will allow to perform - automatic off-line optimization of manufacturing control parameters (lower manufacturing variability, reduced labour costs) - off-line product quality diagnosis (speed up the identification of root causes for quality defects) - on-line diagnosis of manufacturing quality risks (anticipate in real time process misbehaviours). The INNOTEX project will start in the second-half of 2006 and is planned for three years.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Specification Procedures for Industrial Distributed European Realis ation of Systems'.

assistant: **Concept**

Objectives and content Systems forms more than 30% of civil aircraft development cost and are also on the critical path as far as the aircraft development time-scale is concerned. In addition the more complex a system, the more difficult it is to both guarantee its entry into service to schedule and to keep costs within budget. The experience from Airbus programmes is that systems complexity has doubled every five years. For economic and technical reasons most European aircraft programmes are undertaken by consortia of geographically distributed and culturally diverse industrial organisations. Workshare arrangements result in piecemeal solutions for systems specification. The overall result is that global systems validation is only possible during overall aircraft integration prior to certification. This lengthens the duration of the system development (and consequently the aircraft) life-cycle. Improving specification effectiveness requires a more integrated approach to the development and validation of specifications within consortia. Means are required to enable validation of the complete set of aircraft systems specifications prior to system realisation and integration. The problem is particularly important in the European context, since the US Aeronautics Industry comprises fewer, larger companies (e.g. Boeing/Honeywell). In comparison, the competitiveness of the European Industry is reduced This project brings airframers and equipment suppliers together with the objective of reducing the system development cycle significantly (the target is 20%). This will be achieved by developing an integrated set of methods and tools to allow multiple specifications, developed by multiple companies, to be validated in depth and against each other early in the systems developmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'SHAring Researchers’ Passion for Evolving Responsibilities'.

assistant: **Innovation**

Researchers are key actors in finding sustainable solutions to global challenges. With their work they are committed to pursue new discoveries that can make a difference in the quality of life for everyone. These commitment and passion lead them to face constantly evolving responsibilities with an impact on everyone’s life.  SHARPER (SHaring Researchers’ Passion for Evolving Responsibilities) aims to present to all citizens the researchers’ commitment for their increasingly important social role. By making the researchers’ job a shared cultural experience SHARPER will let citizens and researchers be part of the same endeavor for a better world. To synthesize this shared global effort SHARPER project will focus on topics related to Sustainable Development Goals (SDGs) set as Agenda 2030 by United Nations and on the key role that researchers play on different challenges defined by the SDGs. SHARPER will involve 12 cities in 8 regions (Ancona, Cagliari, Catania, L’Aquila, Macerata, Nuoro, Palermo, Pavia, Perugia, Terni, Torino, Trieste) and over 110 institutions. It will consolidate and innovate the experience developed over the last 7 years at regional and national level effectively triggering researchers engagement processes in many cities across Italy. SHARPER also strengthen the collaboration with other Researchers Nights in Europe (8 partners projects in 7 countries) to jointly develop new communication formats, common strategies on impact assessment and a brand new mobility scheme for young researchers and PhD students among European Researchers’ Nights to share experiences and enhance communication and public engagement skills. SHARPER project also includes a strong collaboration with other Nights in Italy to share ideas, impact criteria, communication and awareness
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'GMES - Partnership for User Requirement Evaluation'.

assistant: **Innovation**

The GMES Initial Operations Programme Regulation places the lead of user interaction under EU responsibility. Supporting this, we propose to implement on behalf of the EC a transparent process for user involvement in the definition of user requirements for the Copernicus Marine Environment Monitoring and Atmosphere Monitoring Services for the timeframe 2014-2035, including their translation into coherent service specifications, service data requirements, and technical requirements for the Copernicus space infrastructure.The process, successfully applied by EUMETSAT to its future satellite programmes, and extended to cover the additional complexity of the Copernicus communities, is based on a broad user involvement; consensus is sought at all stages.The project builds on the heritage of user consultation processes already organised by the EC for the Copernicus Services (GMES Implementation Groups,...), results will be consolidated through specific user workshops and expert team meetings, and be approved by the EC through interactions with the Copernicus User Forum.The project is led by EUMETSAT which, based on its proven expertise, will mainly act as a process provider at the service of Copernicus.Three partners expert in the marine and atmosphere sector with wide European representation complement the consortium, ensuring the involvement of all relevant users, and providing additional scientific expertise.A liaison exchange is envisaged with the 2 Copernicus Services to ensure the proper representation of current user requirements and service specifications.The European Space Agency will provide expertise at project meetings on technical requirements for the space infrastructure. Other EU agencies involved in Copernicus (EEA,EMSA...) will also be consulted.The outcome o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Learn to learn human learning process from teleoperated demonstrations' to be submitted under Horizon 2020.

assistant: **Abstract**

Learning from demonstration (LfD) is a paradigm for enabling robots to autonomously learn from demos to perform new tasks. But, environmental changes, expensive demonstration cost, and potential uncertainties caused by data-based learning make it hard to be applied in actual. The project aims to propose a robot skill learning framework from human learning process via a teleoperation interface to achieve human-like skill learning characteristics such as few-shot learning, learning from failed attempts and tentative actions, and strong skill transfer and generalization ability. Five work packages will be taken to realize the objectives. First, a teleoperated interface will be equipped with multi-sensors and special exoskeleton to minimize information difference between humans and robots. After building a scalable primitive skill (PS) library based on task segmentation with multimodal information, new theories of PS learning and PS-based task graph learning are explored. PS will be learned and generalized based on improved meta-learning that is associated and explained by physical laws and neural motor disciplines. The PS-based task graph will be learned from the human learning process, achieving failure reasoning and adaptation to zero/few-shot tasks. Some practical problems e.g. incomplete data set and difference of sim-to-real applications will also be addressed. Finally, the previous theories will be certified by medical robot tasks. The applicant will acquire a solid state-of-the-art interdisciplinary scientific training in the multidisciplinary research fields, such as artificial intelligence, robotics technologies and mechanical design, and that will enable him to generate new scientific knowledge and quickly develop his research career and leadership. The final aim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ultra Low Energy Vertically Integrated Circuits' (ULEVIS) targeting Seventh Framework.

assistant: **Abstract**

The current integrated circuit scaling hits two major roadblocks or walls. One wall is the atomic level feature sizes of the current devices forcing the capabilities of even nano-scale implementations. The other wall is the total power consumed per unit area exceeding the capabilities thermal dissipation techniques limiting the maximum device densities. The solution to the feature size problem is scaling in the orthogonal direction to the conventional device plane - the 3D integration. The solution to the power problem is the use of ultra low power design approaches. However, the 3D integration increases the thermal dissipation problem and ultra low power design can not provide total performance due to low clock speeds unless extremely large number of devices is combined in small areas.  We propose a unique combination of ultra low power design approaches and 3D integration to provide an optimal performance to the user. Low power design eliminates the thermal dissipation problem of the 3D integration whereas 3D integration enables dense device integration in small volumes to solve the space-time trade-off in ultra low power design approaches. The result will be a vertically integrated circuit with power efficiencies several hundred times better than current dedicated processors.