RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Plant Intellectual Property'.

assistant: **Innovation**

The objectives behind this project are to assess the views of the plant breeding industry in respect of: a) the review of Article 27(3)(b) of the Trade Related Aspects of Intellectual Property Rights Agreement (TRIPs) in 1999; and b) any proposal to change the nature of these rights which results from the review of Article 27(3)(b). The aim is to enable the EU to address any issues which might arise and to enable the plant breeding industry to feed into the discussions on the revision of Article 27(3)(b) at both the EU and international level. These objectives will be achieved through the use of questionnaires, interviews, a two day workshop, the publication of an interim report, a two day international conference and the publication of a final report. In particular the project will: 1) identify the intellectual property needs of the plant breeding industry and assess whether the existing provision meets these needs; 2) identify any trade obstacles which may result from the use of existing or proposed EU intellectual property legislation which in turn may affect the proper functioning of the single market; 3) assess whether existing and proposed EU legislation provides a coherent and effective EU policy in respect of plant variety protection, this will include an appraisal of the relationship between the EU and the European Patent Convention (EPC); 4) assess the practical impact and application of these provisions in plant variety protection which are new following the revision of UPOV and introduction of the Community Plant Variety Right, such as the extension of protection to essentially derived plant varieties and the revised farmers' privilege; 5) identify possible areas of conflict or confusion in the substantive provisions of existing and proposed EU intellectual
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Policy Crisis and Crisis Politics. Sovereignty, Solidarity and Identity in the EU post 2008.' (SOLID) targeting Horizon 2020.

assistant: **Abstract**

During the post 2008 decennium horribile the EU has been faced with unprecedented shocks (the Euro-crisis, the Great Recession and its dramatic social consequences, new security threats, the refugee crisis, Brexit) which have coalesced in a disruptive dynamic of unprecedented scope and depth. Conflicts over sovereignty, solidarity and identity sparked a “deep” political crisis, shaking the very foundations of the EU. Surprisingly, however, the utter collapse of the Union has been averted. In dramatic moments EU leaders agreed on significant institutional advances or at least some backstops. How can one explain this peculiar mix of crisis and resilience? The SOLID project posits that sequences of policy crises tend to disrupt routine policy-making, jeopardize its responsiveness, unleash turbulent forms of crisis politics, and put political legitimacy (even polity durability) at risk. At the same time we also posit that severe crisis situation may also activate polity maintenance incentives for keeping the political community together “whatever it takes”. Covering developments since 2009, SOLID ultimately aims at assessing the overall soundness of the EU’s foundations in the wake of the political crisis. In order to capture both disruption and resilience, we propose to disentangle the “deep” political dimension of the crisis from more policy-specific challenges and analyze it through a “coalition-centered approach”, which we have originally devised for the EU polity. Rooted in political economy, comparative political sociology and policy analysis, SOLID will collect extensive data on processes, conflicts and coalitions through qualitative and quantitative methods, including innovative techniques. A major original survey will also be organized. We aim at providing an origi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Breast Cancer Somatic Genetics Study' (BASIS).

assistant: **Concept**

All cancers arise due to somatically acquired mutations in their genomes which alter the function of key cancer genes. Understanding these critical mutational events underlying cancer development is paramount for advancing prevention, early detection, monitoring and treatment of the disease. Breast cancer is the most common class of cancer diagnosed in women worldwide with more than one million cases diagnosed annually. It is responsible for >400,000 deaths per year making it the leading cause of cancer deaths in women and is the most common cause of all deaths in women aged >40yrs. Breast cancer is a heterogeneous disease with a number of subtypes. We propose here to generate complete catalogues of somatic mutations in 500 breast cancers, of the ER+ve HER2- subclass, under the International Cancer Genome Consortium model by high coverage, shotgun genome sequencing of both tumour and normal DNA. All classes of mutations are expected to be detected including base substitutions, insertions, deletions, copy number changes and rearrangements. These catalogues of mutations will afford us statistical power to identify cancer genes that are mutated at a frequency of greater than 3% in this class of breast cancer. Complementary catalogues of epigenomic changes (genome-wide DNA methylation) will be generated for the same cancer samples together with transcript expression profiles. Integrated analyses of these data will be carried out and compared to parallel datasets from other classes of breast cancer and other types of cancer. The potential clinical utility of these findings for detection and monitoring of minimal residual disease will be investigated. Finally, data will be made rapidly available to all scientific researchers with minimal restrictions. The results of this exha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Attosecond physics at nanoscale metal tips - strong field physics in the near-field optics regime' (NEARFIELDATTO).

assistant: **Innovation**

Electron dynamics in metals and nanostructures take place on attosecond timescales. Until today, these extremely fast processes are little understood let alone utilized. With NearFieldAtto, strong-field driven phenomena at nanoscale metal structures will be explored to elucidate collective electron dynamics and to induce optical-field-driven currents -- on attosecond timescales. We will investigate the near-field of a nanotip, resulting from the collective dynamics, both in amplitude and phase. Conversely, we will use the tip as a nanometric sensor to map out the electric field inside the focus of a pulsed laser beam and will directly measure the local phase. In two-tip and molecular junctions, we will explore the ultrafast steering of electronic currents by optical fields, both over a nanometric gap and inside a molecule, taking advantage of the large near-field enhancement the systems offer.My group has recently shown that attosecond physics phenomena can be observed at solids, namely at nanoscale tips [Krüger et al., Nature 2011]. Hence, in NearFieldAtto we will employ techniques well known from attosecond physics with isolated objects, like gas-phase atoms and molecules, to steer laser-emitted electrons with the electric field of few-cycle laser pulses. We will use these electrons as nanometric probes to investigate optical properties of the solid state system and compare the results with those of isolated objects in gas-phase measurements. With two tips facing each other, we will realize a nanometric junction over which we will steer electrons with the optical field. A molecule placed between two tips will enable the investigation of a novel, ultrafast switching mechanism.NearFieldAtto will bring attosecond physics a leap forward as compared to the state-of-the-art
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Systems biology meets evolutionary theory: modeling the genetics and adaptation of complex traits' under Seventh Framework.

assistant: **Concept**

As we learn more about the mechanisms of development, it remains a challenge to understand the relationship between molecular processes and functional characteristics of the organism. The complexity of the networks that link genes and phenotypes is nearly ignored by evolutionary theory, which builds on simple phenomenological models of the genotype-phenotype relationship. These models treat development as a black box, leaving mainstream evolutionary theory ill-equipped to explain how molecular mechanisms evolve. In order to resolve this problem, the current proposal develops a framework for understanding the evolution of complex traits and their genetic basis, integrating methods from systems biology and evolutionary genetics. This novel strategy is first applied to bacterial chemotaxis, a prototype for studying the molecular basis of emergent behavior and its response to selection. A second project examines evolutionary diversification by modeling the origin of distinct ecotypes observed in evolution experiments with Escherichia coli. In both cases, I employ systems-biology models to reconstruct the relationship between molecular mechanisms and phenotypic characters under selection and then apply population-genetic techniques to study how populations evolve on these landscapes. The work on microbial model systems is complemented by conceptual analyses that examine how sexual populations evolve on complex adaptive landscapes. I will study whether higher organisms differ from bacteria in the way they realize evolutionary innovations and whether the high rate of recombination in sexual species has an effect on the structure of molecular interactions. This research will also clarify what signatures of selection are likely to be found in molecular networks. A final research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Interactions between automated energy systems and Flexibilities brought by energy market players' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Five DSOs (CEZ distribuce, ERDF, EON, Enexis, Avacon) associated with power system manufacturers, electricity retailers and power system experts, propose a set of six demonstrations for 12 to 24 months.  Within three years, they aim at validating the enabling role of DSOs in calling for flexibility sources according to local, time-varying merit orders. Demonstrations are designed to run 18 separate use cases involving one or several of the levers increasing the local energy system flexibility: energy storage technologies (electricity, heat, cold), demand response schemes with two coupling of networks (electricity and gas, electricity and heat/cold), the integration of grid users owning electric vehicles, and the further automation of grid operations including contributions of micro-grids.  The use cases are clustered into three groups. Three use cases in Sweden and the Czech Republic address the enhancement of the distribution network flexibility itself. Five use cases in France, Germany and Sweden demonstrate the role of IT solutions to increase drastically the speed of automation of the distribution networks, which can then make the best use of either local single or aggregated flexibilities. Ten use cases in Czech Republic, France, The Netherlands and Sweden combine an increased network automation and an increased level of aggregation to validate the plausibility of local flexibility markets where both distributed generation and controllable loads can be valued. Replicability of the results is studied by the DSOs and industry with an in-depth analysis of the interchangeability and interoperability of the tested critical technology components. Dissemination targeting the European DSOs and all the stakeholders of the electricity value chain will be addressed by deploym
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Romaphobia in the Age of Populism: A Study of UK and Swedish Media and Political Discourse' (ROMAPHOBIA).

assistant: **Concept**

This project will investigate contemporary expressions of racism and xenophobia toward the Roma in the context of the growing populism in Europe. It focuses on two specific contexts, the UK and Sweden, examining how and why Romaphobia becomes particularly widespread in times of socio-political crisis and how it is communicated across media platforms. The project will make a valuable contribution to understanding how Romaphobia in media and political discourse is discursively constructed—often in ways which are easily manageable and deniable by those who disseminate racist discourses. This project combines content analysis and multimodal critical discourse analysis (MCDA) in two empirical studies (1) an examination of UK news media, YouTube, and political discourse on Roma migrants during 2016 when the UK voted to exit the European Union and (2) an examination of  the most influential Swedish editorials and political opinions on Twitter on the controversial ban on begging in Sweden, following 2016, prior and after  the Swedish electoral elections. The project is extremely timely and relevant, if one looks at the current treatment of the Roma in Europe. Despite the significant efforts from European Commission and human rights groups to combat racism and discrimination, most European Roma live on the edge of poverty and are regularly subjected to violence and social exclusion—actions which became more routinised and are little or infrequently articulated in media and political discourse. In addition to contributing to the academic knowledge on discourse and racism, the proposed project will be instrumental for independent media bodies in raising awareness for the kind of concealed forms of racism that have dominated the public discourse. Such critically oriented research i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Measuring Irregular Migration and related Policies' in the context of a Horizon Europe call.

assistant: **Objectives**

Targeted policy responses for irregular migration require better knowledge about the characteristics of the irregular migrant population and dynamics of irregular migration, as well as about the effects of policy measures. Yet, quantitative data relating to irregular migration are scarce, often outdated and contested. The inadequecy of current data makes it challenging for stakeholders to develop and monitor policies. How do legal frameworks in different countries define migrant irregularity? What are the characteristics of irregular migrants in terms of age, gender, nationality or other socioeconomic variables? How can the effects of policy measures, such as regularisation, be assessed? MIrreM adresses the challenge of insufficent knowledge about irregular migration and regularisation in Europe by actively involving relevant stakeholders in every stage of this project – as co-creators of its results and as stakeholders to its mission. In a rigorous comparative and multi-level study, we will assess the policies, data needs and estimates that define migrant irregularity in 11 EU member states, the UK, Canada, the USA and five transit countries. Using several coordinated pilots we will develop new and innovative methods for measuring irregular migration and ‘regularisation scenarios’, and we will explore if and how these instruments can be transferred or scaled up to other socio-economic or institutional conditions.Based on these insights, we will develop two public databases: a) a database with estimates on irregular migrant stocks and b) a database on irregular migration flows, that will also include data on regularisations. Together with the expert groups, we will synthesize our findings into a Handbook on data on irregular migration and a Handbook on regularisation th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unconventional Superconductivity at Microkelvin Temperatures' under Horizon 2020.

assistant: **Concept**

A new frontier is the investigation of quantum materials under the extreme conditions of ultralow temperatures. Its exploration requires the refinement of existing high sensitivity, low dissipation measurement techniques, the development of new ones, and access to ultralow temperature platforms. Quantum materials host a variety of exotic quantum phases, arising from interactions and the effects of strong correlations.  An important example is the emergent unconventional superconductivity in heavy fermion systems when tuned by some control parameter to a quantum critical point. This project combines my expertise with the expertise, facilities and instrumentation of the host group. I will investigate two important unconventional superconductors in this regime, YbRh2Si2 and Bismuth, using high quality single crystal samples. YbRh2Si2 is a prototype quantum critical, heavy fermion metal with a field-tuned quantum critical point. Magnetic measurements on high quality single crystal samples at the lowest fields find evidence for superconductivity. I will address the nature of this superconductivity, the role of quantum criticality, the interplay of electro-nuclear magnetism, and the use of strain as a tuning parameter in this system. This will be done through electrical and thermal transport measurements, investigating their crystalline anisotropy, as well as heat capacity studies. In each case I will exploit new methods tailored for this temperature regime. This work will be coupled with studies of the Meissner effect and anisotropy of the critical field. The recent discovery of superconductivity in Bismuth, a system with very low carrier density, below 0.53 mK has provoked significant theoretical interest in the pairing mechanism.  The first transport measurements will be p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Functional interactions of apolipoprotein E with the ABCA1 lipid transporter and the SR-BI HDL receptor that affect cholesterol homeostasis in circulation and brain' under Sixth Framework.

assistant: **Concept**

Apolipoprotein E (apoE), a lipid transport protein, has been implicated in cardiovascular disease and Alzheimer's disease (AD). ApoE, in normal levels, promotes receptor-mediated clearance of lipoprotein remnants from circulation and protects from atherosclerosis. ApoE, synthesized by astrocytes and neurons, interacts with other brain proteins and affects the development of AD. Recent studies have shown that cholesterol is a risk factor for AD. ApoE interacts with the ABCA1 lipid transporter promoting cholesterol efflux and with the SR-BI HDL receptor promoting both cholesterol efflux and cholesteryl ester uptake, thus affecting cholesterol homeostasis in cells and tissues. Both ABCA1 and SR-BI are expressed in macrophages, liver and brain.It is possible that disturbances in lipid homeostasis may contribute to the neurodegeneration observed in AD. The objective of this proposal is to systematically study the functional interactions of apoE with ABCA1 and SR-BI. These interactions lead to the formation or remodelling of apoE-containing HDL-like lipoproteins and affect cholesterol homeostasis in circulation and brain. I propose to produce wild type and mutant apoE forms, containing targeted point mutations and deletions, using an adenovirus expression system and use them to investigate how structural alterations in apoE affect its functional interactions (binding, cholesterol efflux, cholesteryl ester uptake) with ABCA1 and SR-BI. I also propose to map the domains or residues of apoE involved in the formation and remodelling of apoE-containing HDL-like lipoproteins in brain, by using adenovirus-mediated gene transfer of apoE variants in brain slice cultures.The proposed studies are expected to enhance our understanding of the mechanisms of apoE mediated cholesterol transp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'FLUORESCENCE IMAGING SYSTEM OF PLANTS LEAVES FOR STRESS ANALYSIS OF AGRICULTURAL CULTURES' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

We propose the construction of a Fluorescence Imaging System of plant leaves for stress analysis of agricultural cultures (FISAC) installed in an all-road vehicule, as instrument for agricultural technicians to get substantial information about the cultures. In this way, it will be possible to add the water and minerals needed by the plants contributing to the prevention of plagues and to a more efficient production.