RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'PROTAC Linker Design: towards Functionality' (PREDICT) under Horizon 2020.

assistant: **Objectives**

Proteolysis Targeting Chimeras (PROTACs), small molecules capable of inducing degradation of a target protein, represent a novel strategy to design advanced chemical probes and therapeutic agents with the potential to target so far “undruggable” proteins. PROTACs are heterobifunctional molecules consisting of binding ligands to an E3 ubiquitin ligase and a protein of interest, covalently connected by a linker. Formation of a ternary complex of target protein, PROTAC and E3 ligase allows ubiquitination of the target protein, leading to its subsequent degradation by the proteasome. Due to the complexity of this ternary system, rational PROTAC design is highly challenging and novel PROTACs are to date commonly derived from trial-and-error approaches, typically using simple linkers to connect the two binding ligands. The potential to significantly stabilize and in doing so bias productive ternary complex formation, through design of functional linkers has not been exploited so far. My goal for this project is to identify and explore novel functional linker motifs which will enhance interactions within the ternary complex, such as PROTAC-ligase, PROTAC-target as well as cross-interactions between the E3 ligase and the target protein. The effects of halogen bonding, metal coordination and restricted conformational flexibility of the PROTAC linker on ternary complex formation and PROTAC degradation activity and efficiency will be systematically studied, benchmarked against related PROTAC degraders with non-functionalized linkers and taken as the basis to derive valuable structure-activity relationships. My long-term vision is to capitalize on this Fellowship to enhance my career by developing a rational-design strategy for novel PROTAC degraders capitalizing on functionalized
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Reducing rumen complexity to its essential components to understand and modulate ecosystem structure and function'.

assistant: **Concept**

Ruminants represent a paradigmatic case of obligatory host-microbiome relationships. These animals require complex microbial communities to digest plant fibers.  Which functions are essential and how the assembly of these functions impacts host physiology remain unknown. My goal is to understand the underlying aspects that allow the host and its microbes to coexist and to identify the essential requirements of this microbial community to sustain the life of the host. This proposal aims to address this ambitious and fundamental challenge. These efforts build on a unique research platform involving germ-free ruminant animals, modeling, genomics, metabolomics, as well as animal and microbial physiology, developed over nine years of experience working with animal microbiomes. To do so, I propose to identify the minimum rumen community (RuMinimum) using top-down and bottom-up approaches that will complement each other. Once defined, the RuMinimum will serve as a platform for experimenting and understanding how the ecosystem functions and supports the life of the host, and how to modulate it. We will specifically augment and decrease functional redundancy and richness at different edges of the trophic network and measure their impact on ecosystem function and host physiology.  These endeavors will allow us to learn how to modulate host physiology towards better feed efficiency or lower methane production, which will have an immense environmental and agricultural impact.  The results of this project will be relevant not only to ruminants but also to other gut ecosystems and anaerobic, carbon-degrading communities in general.  Our research efforts will lead to new paradigms and concepts vis-a-vis microbial community assembly, the design of synthetic microbial communities, and h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Melanoma Early Warning System'.

assistant: **Concept**

However, there are several tools and solutions for aiding the melanoma detection (variable dermatoscopes, full-body mapping tools and Applications), they were not able to achieve breakthrough in the early diagnosis phase. It comes from the wrong methodologies. There are two types of available tools: 1) diagnostic tools, whit the aim of diagnosing skin-cancer without human intervention, and 2) medical equipment, which help the work of dermatologist during the examination in a doctor’s office. The problem with first methodology (artificial based skin-cancer diagnosis) is that these do not work reliable or do not work at all. The main problem of the second methodology is the very rare examination frequency. An average health conscious European adult visits skin-cancer screening in every 3-7 years. In contrast with these, MERWIS offers a solution that focuses on increasing the examination frequency, where the system does not need to establish a full diagnosis. MERWIS only looks for evolution (change) of every single monitored mole, but with high or very high frequency.The validated and demonstrated MERWIS prototype is based on the fact that most clinical signs of melanoma are all visible. Through using the combination of a special body-mapping cabin, a mobile application based “self dermoscopy”, and a computer assisted qualitative data analysis software we can detect all the visible changes of melanoma ABCDE. Furthermore our system uses a custom made distributed ledger technology-based network cloud solution. Based on this framework it is possible to build the MERWIS decentralized database on a maximum security level and ensure scalability. The aim of this Phase 1 project is to carry out an extended feasibility study consisting of market assessment, business model validatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Career Development Fellowships in the National Technology Centre Programme', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Career-FIT is a new trans-national scheme that offers an opportunity for experienced researchers to develop their careers n market focused applied research in Ireland's Technology Centres. Covering a wide range of academic and industry areas aligned with Ireland's Smart Specialisation Strategy, the 15 Centres were established to encourage greater efficiency in the interaction between researchers, industry, and the public sector, in research that promotes economic growth by its direct relevance to industry agendas. Each multidisciplinary Centre offers excellent facilities and equipment for Fellow use: experienced scientific staff to support the Fellow’s research, and extensive enterprise relationships on which market focused applied research can be progressed. Following two widely publicised calls that seek to attract the highest quality researchers with their own research proposals, the Career-FIT programme offers 50 fellowships of 36 months’ duration for incoming mobility to the Centre Hosts, with an enterprise secondment option during the Fellowship. Selection is through a transparent process based on demonstrated excellence of the applicant, potential of the research programme, host organisation capacity to provide a developmental environment, and training/career development impact of the Fellowship. Fellows are mentored by an experienced Centre mentor(s) concerned not just for their scientific progress but also their training and development in line with agreed career goals.  They will also have support from a Professional Development Advisor and will further benefit from participation in a structured development training programme that targets enhancement of personal effectiveness as well as competencies relating to innovation management.  As a new programme offeri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multi-ObjecTive design Optimization of fluid eneRgy machines' under Horizon 2020.

assistant: **Concept**

The MOTOR project focuses on ICT-enabled design optimization technologies for fluid energy machines (FEMs) that transfer mechanical energy to and from the fluid, in particular for aircraft engines, ship propellers, water turbines, and screw machines. The performance of these machines essentially depends on the shape of their geometry, which is described by functional free-form surfaces. Even small modifications have significant impact on the performance; hence the design process requires a very accurate representation of the geometry.Our vision is to link all computational tools involved in the chain of design, simulation and optimization to the same representation of the geometry, thereby reducing the number of approximate conversion steps between different representations. The improved accuracy and reliability of numerical simulations enables the design of more efficient FEMs by effective design optimization methods. MOTOR also exploits the synergies between the design optimization technologies for the different types of FEMs that have so far been developed independently. MOTOR adopts a modular approach for developing novel methodologies and computational tools and integrating them into real process chains, contributing• a volumetric mesh generator with exact interface matching for multi-domain geometries enabling high-order multi-physics simulations with enhanced accuracy, • an isogeometric analysis simulation toolbox for CFD, CSM, and FSI problems and advanced interactive visualization toolkit for high-order solutions, and • automatic shape optimization based on a multi-level approach in the parameterization enabling different levels of shape variety to combine design space exploration with local searches. The effectiveness of our approach in terms of reduced time t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Revealing the ubiquitin and ubiquitin-like modification landscape in health and disease' (Ubl-Code).

assistant: **Innovation**

Post-translational modifications (PTMs) of proteins are a major tool that the cell uses to monitor events and initiate appropriate responses. While a protein is defined by its backbone of amino acid sequence, its function is often determined by PTMs, which specify stability, activity, or cellular localization. Among PTMs, ubiquitin and ubiquitin-like (Ubl) modifications were shown to regulate a variety of fundamental cellular processes such as cell division and differentiation. Aberrations in these pathways have been implicated in the pathogenesis of cancer. Over the past decade high-throughput genomic and transcriptional analyses have profoundly broadened our understanding of the processes underlying cancer development and progression. Yet, proteomic analyses and the PTM landscape in cancer, remained relatively unexplored.Our goal is to decipher molecular mechanisms of Ubl regulation in cancer. We will utilize the PTM profiling technology that I developed and further develop it to allow for subsequent MS analysis.  Together with cutting-edge genomic, imaging and proteomic technologies, we will analyze novel aspects of PTM regulation at the level of the enzymatic machinery, the substrates and the downstream cellular network.  We will rely on ample in-vitro and in-vivo characterization of Ubl conjugation to:a. Elucidate the regulatory principles of substrate specificity and recognition. b. Understand signalling dynamics in the ubiquitin system. c. Reveal how aberrations in these pathways may lead to diseases such as cancer. Identifying both the Ubl modifying enzymes and the modified substrates will form the basis for deciphering the molecular pathways in which they operate in the cell and the principles of their dynamic regulation. Revealing the PTM regulatory code prese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Low-cost, High-efficiency FLYwheel Energy Recovery System for On-highway Commercial Vehicles' (FLYwheel).

assistant: **Concept**

The aim of the feasibility study is for Flybrid Automotive Ltd, a world leader in high-speed flywheel energy storage, to evaluate the technical, market and commercial opportunities of developing an innovative kinetic energy recovery system (KERS) for On-highway commercial vehicles, based on an existing, low-cost Off-highway product.Commercial vehicle operators are under continuous pressure to reduce operating costs of which fuel is a significant part. Flybrid's KERS product will provide a low-cost, short-payback fuel saving product for which there is significant market appetite. Fuel savings also equate to the global issue of CO2 and emissions reduction. The product will be primarily developed by Flybrid, supported by European tier 1s and OEMs in the commercial vehicle industry.The study will look at a number of key areas across a range of trucks/buses models and OEMs:- fuel and CO2 savings- KERS product cost- commercial attractiveness to both the vehicle purchaser and across the full supply chain- market size and growth opportunitiesThe study is expected to show that a simple, low-cost product can be developed that will:- offer 20% fuel and CO2 savings- deliver a <3 year payback on the KERS system cost to truck / bus operators- generate significant market pull and volume growth (10k units rising to 50k units at maturity)- create substantial incremental revenue and profit generation within the full value chain (almost entirely based within the EU).- achieve €38mil profit across the supply full chain at 10k units/annum with the mature potential for €180mil at 50k units/annumIt is likely that phase II funding would be sought to support the progression of the opportunity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'PROactive Strategies and Policies for Energy Citizenship Transformation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

EnergyPROSPECTS (PROactive Strategies and Policies for Energy Citizenship Transformation) will work with a critical understanding of energy citizenship that is grounded in state-of-the-art SSH insights. Our 3-year project aims to develop a broad understanding of energy citizenship, which we understand as a policy concept, a socio-technical imaginary, a knowing-of-governance, i.e. a social construction of desirable/normal civic agency in future energy systems. We identify and examine a range of cross-cutting issues in energy citizenship, which will inform iterative typology development and criteria for case selection. Drawing on existing databases and a search for new cases, we will select 500 initiatives and undertake mapping and typology refinement exercises to demonstrate the depth/breadth of the energy citizenship concept in theory and practice. 40 cases will be selected for in-depth analysis exploring development, evaluation, intermediaries, institutions, governance and ICT in energy systems. Using a multi-actor perspective, we will develop an empowerment toolkit for practitioners and citizens, co-create viable strategies, and develop new business and social innovation models, and new forms of organisation to advance energy citizenship. A critical part of the research involves analysing the external and internal contextual conditions as they support or hinder energy citizenship in its various forms. Based on the analysis we will match suitable models and forms of organisation with different countries, regions and contexts. We will conduct a citizen survey to appraise the validity of various scenarios and discuss and refine results in citizen workshops and policy forums. We will produce practical policy outputs which will be revised with policy actors in knowledge ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Augmenting Human and Artificial Intelligence to Scale Innovation' (AUGMENTED-HUMANS) under Horizon 2020.

assistant: **Objectives**

The rise of artificial intelligence is driving the fourth industrial revolution and is steadily disrupting traditional business models, workplace practices and performance management. Despite the astonishing rate of progress with AI technology, problems and challenges in the current business environment cannot be solved by machines alone and require robust human-machine hybrid solutions; however these are still largely experimental with limited business adoption . A further challenge is that European business investment in AI applications has been sub-optimal due to limited capability and know-how  and this has just recently been identified by the EU Commission as a key focus area for co-ordinated action and investment . This proposal highlights a key opportunity to take a human-centred approach to building AI applications that incorporate game-based technologies that have shown great empirical and anecdotal promise in creating AI applications that drive business innovation. To address the challenges of the efficacy of human-machine interactions and AI adoption, in Augmented-Humans I will investigate how we can use game-based technologies (games, gamification, virtual and augmented reality) as mediators of engaging interactions and problem solving between human and machine that generate data, develop insights, facilitate business problem solving, and aid both human and machine learning. The outputs of this project will include the development of reusable game-based technology toolkits and applications for (a) Business systems for end-user engagement, stakeholder collaboration and robust decision support systems, (b) AI engineering and data science in utilising game-based technologies for data generation, machine learning, and developing human-machine collaboration syste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'EPIGENETICS FOR FEMALE PERSONALIZED CANCER CARE' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

CLINICAL NEEDEvery year in the EU ~45,300 and 330,000 women are diagnosed with ovarian and breast cancer respectively & 28,800 and 90,000 of these two groups of women will die as a consequence of these diseases. Currently there are no tools available that allow for:a) Effective screening of ovarian and/or breast cancer of sufficient sensitivity and specificity to avoid potential over-diagnosis, or;b) Stratification of patients into optimal personalised therapy regimes in ovarian/breast cancer.EpiFemCare ADVANCESProgress in personalised cancer medicine will only be possible with the development of bioassays involving the analysis of easy accessible biomaterials that contain stable target molecules reflective of disease. We will establish and clinically validate a series of blood tests based upon DNA methylation technology that will facilitate both early detection and prediction of therapeutic outcome in breast and ovarian cancer.CONSORTIUMOur pan-European academic-industrial consortium demonstrates diverse clinical, scientific & industrial expertise. We have access to the latest state of the art technologies and, integrally, the best available cohort and clinical trial sample sets required to ensure the success of the EpiFemCare program. GATC-Biotech and Genedata are Europe’s leading providers of DNA sequencing and bioinformatics for biomarker development and have developed serum DNA based prenatal tests. The clinical partners have access to unique cohort and clinical samples collected from >200,000 women well in advance of disease (UK Collaborative Trial of Ovarian Cancer Screening) or before and during treatment (SUCCESS Trial).IMPACTAs a result of refined and improved patient stratification, EpiFemCare will:-Reduce the late stage presentation of ovarian & breast cance