RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Narration, linguistic expression and discourse structure: explorations of orality in Occitan and French' to be submitted under Horizon 2020.

assistant: **Abstract**

This project is an exploration of the linguistic complexities around the concept of ‘orality’, as attested in different expressions of ‘oral narrative’ in Occitan and French. It will be corpus-based and comparative, looking at a key set of temporal features in narratives collected in a traditional oral setting, in contemporary oral settings and in published ‘literary’ versions of oral narratives. Crucially, the project seeks to revisit the definition of ‘orality’ and to contribute to novel conceptual models. Outputs will take the form of peer-reviewed journal articles, a unique digitised Occitan corpus, digital annotation tools, conference papers and an intersectoral workshop. Given the location of this MSCA in Belfast, and the importance of oral storytelling in Irish cultural heritage, an integral part of the project involves public engagement around cultural practice and minorised languages, and the establishment of links between cultural sectors internationally. The supervisor’s (JC’s) expertise both overlaps with, and complements the experienced researcher’s (MV’s) skills, such that the project will be of mutual benefit at both individual and institutional level. In line with MSCA objectives, the experienced researcher will diversify her research skills (theoretical, analytical and digital), will benefit from excellent linguistic, research and professional training, and will enhance her career profile through international and intersectoral mobility.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular changes and genetic susceptibility in relation to air pollution and environmental tobacco smoke' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

- To study the effects of air pollution and Environmental Tobacco Smoke (ETS) on cancers of the lung, bladder, pharynx, and larynx, plus COPD emphysema in non-smokers in nine European countries. This will be done with a nested case-cohort design in the EPIC investigation (450000 volunteers already recruited), by the means of biomarkers to exposure and susceptibility. In total 1000 randomly chosen controls will be analysed.- To assess exposure levels by expert interpretation of already available questionnaires plus objective information on air pollution in different European cities. Exposure to ETS will also be assessed by measuring cotinine in the blood.- To assess the effect of dose and length of exposure to environmental polluants on biological endpoints, such as DNA and hemoglobin adducts. Hemoglobin and WBC-DNA adducts formed by nitropyrenes, PAHs and other environmental contaminants (mainly due to traffic pollution and occupational exposures) will be measured. The adduct technology allows at least a partial separation of different sources of exposure (nitroarene adducts refer mainly to diesel exhaust, 4-aminobiphenyl-hemoglobin adducts to active or Environmental Tobacco Smoke).- To study the relationship between adducts and disease according to genotypes for metabolism of the relevant carcinogens and DNA according to a newly developed technique.- To evaluate the prote
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'From machines to smart systems: Cloud-based IoT for lift modernization and predictive maintenance', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Used every day, the lifts provide an essential means of fast, safe and comfortable access to different floors in buildings. The installation of lifts in new or existing buildings has an increasingly important role to play in an ageing society and as a growing population is moving to cities. In the city of the future, the most important transportation system will not be cars, buses, subways, or even futuristic monorails, it will be the lift! Europe counts today more than 5.85 million lifts in service. Around 70% of them were installed before 1999 and they do not assure the highest safety levels currently expected, which means that fatal accidents still occur in the EU. Moreover, lifts are a major capital investment for building owners and managers. Current maintenance procedures are based on periodic inspections which, despite the number of visits, produce poor results in terms of performance (MTTR and MTBF) and uptime, implying high maintenance costs and low effectivity. The combination of old systems and poor maintenance models is holding back the EU lift market. The lack of data impedes the optimization of maintenance models. Leveraging digital technologies such as IoT (Internet of Things) to extract data out of connected lifts can solve this problem. Our company IOTTY is an Italian start-up fully aware of the importance of using the Internet of Things in the lift industry to anticipate equipment failures and respond more quickly to critical situations. Addressing the concern of lift manufacturers, maintenance companies, building owners and insurers, we present e-BlueBox, an innovative tool for lift modernization that leverages the IoT to reach higher standards of safety and implement predictive maintenance. With clear benefits (-25-30% accidents, -10-40% maintenance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'EPIGENETIC-GENETIC-MENTAL HEALTH CASCADE BASED PERSONALISED PREVENTION OF NON-COMMUNICABLE DISEASE IN ADOLESCENTS DIAGNOSED WITH AUTISM (ETHEREAL)'.

assistant: **Concept**

Five Noncommunicable Diseases (NCD) – diabetes, cardiovascular disease, cancer, chronic respiratory disease and Mental Health Disorders (MHD) – account for 86% deaths and 77% disease burden in the WHO Europe region. Of these five NCDs, MHD is unique as it has a complex bi-directional  relationship with the other four major NCDs, meaning that, on one hand, it could be the initiator of the other NCDs, or other NCDs could lead to MHD which, in turn, can further aggravate the primary NCD leading to a vicious circle. Recent research identified MHD as the highest ranked NCD in adolescent population. A specific group in this population that is 3 - 6 times more vulnerable for developing MHD and subsequent NCD is the adolescents diagnosed with Autism Spectrum Disorders (ASD). There is no Evidence Based Intervention (EBI) for preventing MHD in an ASD adolescent since 1) the major risk factors are in-grained in their biological process and 2) they present with multiple MHD comorbidity.  Personalisation is the key to prevent their already vulnerable mental states making transition to an MHD - ""which"" EBI is appropriate for ""which"" ASD adolescent and ""how"" to choose it - an unsolved question. Because of their neurobiological characteristics, personalisation must be done at biological level.Recent research showed how the environmental factors can alter gene expressions that leads to an MHD through Epigenetic-Genetic/metabolomic-Mental health (EGM) process. Using quantitative modelling of this process, ETHREAL will develop a personalised, flexible, single service delivery model that will empower an ASD adolescent to self-control their environmental factors while seamlessly accessing the community care services to prevent their mental health making transition to an MHD - a unique
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Role of the transcription factor STAT3 in Schwann cells in the processes of degeneration and regeneration in damaged nerves' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Nerve repair depends critically on injury-induced Schwann cell dedifferentiation, an adaptive injury response that generates the denervated Schwann cell, a cell that enables peripheral nerves, unlike CNS tissue, to regenerate after injury. The transcriptional programmes that control the generation of the denervated repair cells are therefore an important issue in nerve biology.The host laboratory has recently defined the concept of negative regulation of myelination, implicated two transcriptional regulators, c-Jun and Notch, in the control of dedifferentiation and the formation of the denervated cell, and shown that Schwann cell c-Jun has an essential role in controlling nerve regeneration.In peripheral nerves, the Signal Transducer and Activator of Transcription 3 (STAT3) is rapidly activated at the injury site following nerve transection, but the function of this factor in nerve injury has not been investigated. Perhaps the best known function of STAT3 is the positive regulation of cellular survival, a function that in many cell types is mediated by its ability to up-regulate the gene expression of Bcl-xL and Bcl-2, anti-apoptotic factors. Mechanisms that ensure the sufficient Schwann cell survival in injured nerves are critical for nerve repair.Thus, the present project will explore additional control systems in injured nerves and in particular whether STAT3 signalling in Schwann cells is an important mediator of the adaptive injury response of these cells in damaged nerves. Our key aims are to test whether STAT3 is required for the survival of denervated Schwann cells, the formation of the Schwann cell columns (bands of Bungner) that serve as substrates for regenerating axons and the remyelination of regenerated axons.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dual Mn/Ni-catalysed functionalization of unreactive sites of amines' (DualCatAmine).

assistant: **Concept**

With most bioactive molecules, such as pharmaceuticals, and agrochemicals, being complex amines, efficient synthesis and functionalization is of crucial importance. Although much progress has been achieved, conventional strategies, especially those targeting the functionalizations of less reactive sites, are particularly ineffective. The current methods typically require forcing conditions, such as strong oxidizing agents and stoichiometric organometallic reagents or the installation of directing groups and N-protected functionalities, that jeopardize their utility in practical synthesis. To address these limitations, herein, we propose a new strategy for the direct and efficient functionalization of amine frameworks at their otherwise unreactive sites. Specifically, I will explore the dual Mn/Ni-catalytic systems, where the unique features of the Mn complexes drive the temporary activation of an amine generating a transient reactive imine intermediate, which in turn undergoes the functionalization step enabled by the Ni complexes. Attractively, the overall transformation employs Earth-abundant metals and occurs directly in ‘one pot’ without any stochiometric activating reagents, thereby underscoring the high atom economy enabled by multicatalysis. The mechanistic studies will be used to untangle catalytic aspects assisting the rational methodology development. Attractively, a range of functionalizations, including arylation, alkylation, olefination, and halogenations at different sites can be achieved, which will open up innovative routes to industrially important and value-added chemicals. This highly original project combines the strengths of complex systems chemistry with the power of catalysis to address the current limitations of organic synthesis, yielding a proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Internet of Things Environment for Service Creation and Testing' (2007-2013).

assistant: **Concept**

To date implementations of Internet of Things architectures are confined to particular application areas and tailored to meet only the limited requirements of their narrow applications. The ICT workprogramme highlights the importance of interoperability between the silo solutions and different technologies used in these disjointed sectors. Sensors/objects that provide information or perform as actuators implementing actions in the real world are plentiful and the range of communication technologies, networking protocols, information types and data formats used to exchange information or control data is vast.To overcome technology & sector boundaries and therefore dynamically design and integrate new types of services and generate new business opportunities requires a dynamic service creation en-vironment that gathers and exploits data and information from sensors and actuators that use differ-ent communication technologies/formats. To accelerate the introduction of new IoT enabled business services (in short IoT services) an effective dynamic service creation environment architecture needs to provide:1.\tOrchestration, i.e. composition, of business services based on reusable IoT service com-ponents,2.\tSelf-management capable components for automated configuration and testing of services for things",3.\tAbstraction of the heterogeneity of underlying technologies to ensure interoperability.IoT.est will develop a test-driven service creation environment (SCE) for Internet of Things enabled business services. The SCE will enable the acquisition of data and control/actuation of sensors, ob-jects and actuators. The project will provide the means and tools to define and instantiate IoT services that exploit data across domain boundaries and facilitate run-time monitoring whic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'CHEMICAL REACTIONS AS CAUSES AND LAWS'.

assistant: **Concept**

CREACAL will realise an unprecedented study of chemical reactions from the perspective of causation and lawhood, with the aim to establish a rigorous framework for the philosophical investigation of chemical reactions.  Chemical reactions are fundamental to science and engineering as they identify the causes of the transformation of a specific set of chemical substances, while at the same time representing lawlike generalisations about transformations of types of chemical substances. However philosophers have neglected chemical reactions; they have not examined them either with respect to causation or with lawhood. This is a clear lacuna in the philosophical literature given that reactions are the main means with which scientists explain chemical transformation. CREACAL will synthesise these two fields to offer an account of laws and causation that not only does justice to the rich yet under-explored knowledge of reactions, but that also deepens our understanding of causation and laws themselves. CREACAL’s results will contribute to science by illuminating the intricate features of chemical reactions that are revealed by viewing them as causes and laws. Moreover, it will fill a significant gap in philosophy by introducing a new case study for the investigation of causation and lawhood, while also achieving genuine progress in philosophy of chemistry that will further consolidate the latter as an important field within philosophy.


**Keywords:** Metaphysics of Science, Philosophy of Science, Philosophy of Chemistry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SCALABLA: a platform for elastic multimedia communications enabling natural social interaction and personalization' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The mobile phone service is the most popular IT service worldwide with more than 5 billion users. However, many analysts agree that a novel wave of technologies combining WebRTC with Cloud Computing, is going to disrupt it bringing a new media communications era. This opens a multi billion business opportunity and developers are the key to it: currently, more than 10 million developers worldwide are avid of new platforms enabling innovative media services.In this project we present SCALABLA: a technological platform that makes possible for developers to create professional WebRTC multimedia services adapted to vertical domains (e.g. e-health, e-learning, social TV, etc.) For attracting developers, SCALABLA shall be accessible with lower costs and shall offer three differential features: social scalability, which enables new social communication topologies currently not available; personalization, including the ability of enriching and customizing video streams accordingly to users’ needs and context; and DevOps, which means that the platform simplifies most of the tedious tasks developers need to execute.SCALABLA is built on top of FIWARE technologies, which have been demonstrated in operational environments, and which guarantees its technical feasibility. In addition, a preliminary market analysis shows huge interests in SCALABLA concepts from different relevant market stakeholders and developers as well as the ability of the platform to open a whole new “blue ocean” market filling the gap between real-time media and live media broadcasting.This project will result in an elaborated business plan providing a detailed market analysis, a commercialization plan, a financial plan and a feasibility assessment analyzing risks, IPR protection mechanisms and regulatory constrai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Detection and interpretation of de novo mutations and structural genomic variations in mental retardation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Mental retardation, like most common neurodevelopmental and psychiatric diseases, shows a strong genetic component, but these underlying genetic causes remain largely unknown. For a long time it was hypothesized that these kind of common diseases are mainly caused by common inherited genetic variants with reduced penetrance. In contrast to this common variant-common disease hypothesis, I here hypothesize that a large proportion of this so-called “missing heritability” for conditions such as mental retardation, schizophrenia, and autism lies in de novo genetic variation that is rapidly eliminated from the population because individuals with such diseases have severely compromised fecundity.My previous work using microarrays has already demonstrated de novo genomic copy number variations in mental retardation and in schizophrenia. However, microarrays do not allow us to capture the most common form of de novo mutations, those occurring at the nucleotide level. Technological innovations now for the first time allow us to comprehensively study the entire genome of an individual for genomic variations at all levels. In this project I will explore the de novo mutation hypothesis in whole exome and whole genome sequence data from patients with mental retardation. I will optimize and apply whole genome sequencing strategies using patient-parent trios, both in rare mental retardation syndromes as well as common forms of mental retardation. Guidelines for pathogenicity will be established by computational studies aimed at unraveling genotype-phenotype correlations in these family-based genome sequence type datasets.This project will contribute significantly to resolving the genetic causes of reproductively lethal disorders such as mental retardation, provide critical knowledge on