RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dissecting the role of mitochondrial dynamics in pancreatic carcinogenesis' (2014-2020).

assistant: **Innovation**

OPA1 Educates the Nucleus in Pancreatic CANcer.  Pancreatic cancer represents an unresolved health burden, showing abysmal chances of survival and refractoriness to conventional and immunological therapies. Significant benefit will be gained from a better understanding of molecular mechanisms leading to cancer formation, with the goal to curtail disease incidence and improve the opportunities to treat it early. The study will describe how mitochondria and nuclei communicate to facilitate pancreatic cancer initiation. Building from my prior research in metabolic-dependent histone acetylation, and leveraging on the host laboratory expertise in mitochondrial dynamics, I designed a roadmap for the study of how mitochondrial activity is altered during pancreatic carcinogenesis and whether that can be exploited for therapeutic purposes.  I will decipher the specific role of major cristae-remodeling factor OPA1, which is an unfavorable prognostic factor for pancreatic cancer patients. I will seek how OPA1-altered expression impacts mitochondrial function and metabolite availability in mouse pre-malignant cells, using in vivo models of pancreatic carcinogenesis. My previous experimentation found that metabolite-dependent histone acetylation is critical for the initiation of pancreatic carcinogenesis. I will now investigate whether OPA1-mediated mitochondrial rewiring impacts citrate and acetyl-CoA abundance in a way that alters the levels of histone acetylation. Epigenetic reprogramming will be further investigated in various OPA1 transgenic mice. Finally, the therapeutic potential of OPA1 targeting will be addressed using both genetic and chemical approaches using resources recently developed at the host laboratory. The project represents a career-defying framework for the stu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Embedded MAgnetic Components' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

MRAM is the candidate of choice for the universal semiconductor memory, offering low power consumption, high speed, high density and permanent storage. The current state of the art is based on Back-End Module (BEM), where the MRAM module is inserted at the end of the process, using multiple layers onto a CMOS substrate. But this technology presents some drawbacks that limit its possibilities, its market penetration and its implementation in nano-scale devices.EMAC project will introduce a decisive breakthrough in MRAM technologies by exploring a non-conventional technological approach using a Front End Magnetic Module (FEM) integrated at the CMOS level. The challenge in FEM approach is the integration of magnetic material within an industrial front-end process. The purpose of the project is therefore to investigate enabling technologies for the manufacture of advanced CMOS devices using front-end embedded magnetic materials, from 0.25µm 4kbits memory prototype towards sub-90nm technologies.The EMAC consortium gathers a high transnational network of 9 industrial partners, institutes and universities located in 4 member states that will joint their expertise to work at the frontier of the knowledge.The overall tasks of the project can be roughly divided into three groups:The first group concerns the technological problems: EMAC will explore different methods of oxide and ferromagnetic metal deposition and the subsequent cleaning of wafers after deposition of ferromagnetic metals.The second group of concerns the characterization of fabricated layers and stacks: the routine characterization of fabricated layers and structures will be carried out in each laboratory.The third group of tasks covers the problems of process flow definition, layout, design and test of device: The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'XBP1 and Endoplasmic Reticulum Stress in Mucosal Homeostasis' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Endoplasmic reticulum (ER) stress allows cells to cope with misfolded proteins through the Unfolded Protein Response (UPR). We have recently reported that unabated ER stress, a consequence of genetic deletion of X-box binding protein-1 (XBP1), in intestinal epithelial cells (IECs) leads to intestinal inflammation reminiscent of inflammatory bowel disease (IBD), and polymorphisms in XBP1 were associated with Crohn s disease and ulcerative colitis.The current proposal is based on this central discovery, and rests on three major pillars. 1. Elucidation of the molecular pathways that connect unabated ER stress with inflammation, with the potential to identify novel therapeutics. 2. Testing the hypothesis that XBP1 deficiency may regulate colorectal cancer development, both sporadic and inflammation-associated. 3. Addressing the hypothesis that XBP1 and ER stress may contribute to the molecular pathology of primary sclerosing cholangitis (PSC) via affecting cholangiocyte biology. Insight from these studies may have implications well beyond mucosal inflammation as ER stress mechanisms have been suggested to play a role in a wide variety of diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Citizen-powered data ecosystems for inclusive and green urban transitions' to be submitted under Horizon Europe.

assistant: **Abstract**

Urban ReLeaf is an action-oriented mission to advance citizen-powered science as a central resource for inclusive urban green planning in support of local policy making, European strategies and monitoring systems (e.g., the Green Deal, Copernicus), and global efforts such as the SDGs (e.g., Target 11.7) and GEOSS. The project will: (i) assess current urban greening policy processes within six European cities and co-create solutions that use citizen observations to complement existing data ecosystems and decision-making; (ii) support the validation and long-term inclusion of active and passive data from citizens for urban environmental monitoring within authoritative data streams, including GEOSS & Copernicus; (iii) Mobilize and empower communities through widespread participation in issues of public interest surrounding urban green infrastructure; (iv) develop a community of practice around topics related to the use of citizen observations for urban planning to foster knowledge exchange and develop capacities across multiple sectors; (v) produce flexible and innovative governance solutions to help scale-out inclusive urban green transitions in support of the European Green Deal and UN Sustainable Development Goals; and (iv) promote recognition, adoption and trust of citizen observations and other novel data ecosystems for environmental monitoring to trigger innovation within public institutions. The project is coordinated by IIASA, who led the WeObserve project, and involves partners from previous successful H2020 citizen observatory projects and as well as six cities (Athens, Cascais, Dundee, Mannheim, Riga Utrecht) that are willing to embrace new data streams for urban greening planning and policy making and to fully engage with citizens including marginalized and vul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Targeting the Plant Cysteine Oxidases to Regulate Plant Stress Tolerance' under Horizon 2020.

assistant: **Concept**

Population growth and climate change mean that food security is an emerging global challenge. Crop loss due to flood, drought and other weather extremes is something that disproportionately affects the world's poor, but also has widespread international impact. There is an immediate and urgent need to develop tools and strategies to improve crop tolerance to such abiotic stress. One effective mechanism towards this goal is molecular engineering of crops to withstand prolonged abiotic stress. Group VII Ethylene Response transcription Factors (ERF-VIIs) have a key role in plant stress tolerance, in particular flooding but also salinity, high temperature, drought and oxidative stress. ERF-VIIs are readily degraded, but their stabilisation has led to improved flood tolerance in model plants and crops. Consequently, ERF-VIIs are focal points for engineering abiotic stress resistance in crops. ERF-VIIs are destabilised when their N-terminal cysteine (Nt-Cys) residues are oxidised, making them substrates for the N-end rule pathway of protein degradation. I discovered that Plant Cysteine Oxidase enzymes (PCOs) catalyse this oxidation, incorporating molecular oxygen into ERF-VII Nt-Cys residues to form Cys-sulfinic acid (CSA), and that PCO activity is sensitive to oxygen availability. These enzymes therefore control ERF-VII stability and mediate the response to flood-induced hypoxia. I propose generating tools and knowledge to manipulate PCO activity, modulate CSA formation and stabilise ERF-VIIs. This is an attractive and tractable strategy to enhance stress tolerance in plants. The project will require (i) the development of efficient tools and assays to detect and quantify CSA, (ii) an understanding of the breadth of PCO activity for non-ERF-VII substrates, and (iii) an under
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quantum Engines in Ultracold Gases' in the context of a Horizon Europe call.

assistant: **Objectives**

Engines are ubiquitous: Heat engines have been and still are the driving force of modern life since the industrial revolution, and molecular motors power life on earth with astonishing efficiency. Current technological miniaturization is pushing engine design into areas where quantum properties need to be considered, which can drastically change the performance of engine-like processes. While initial mechanisms for motor operation have been demonstrated, the operation of autonomous quantum engines or extracting work from such a motor is elusive.QuantumEngine will combine novel concepts and innovative methods of ultracold atoms to develop autonomous quantum engines in the single-atom and many-body limits that provide cyclic motion or work.First, it will engineer energy conversion in such quantum systems at the level of single atoms and single energy quanta to increase efficiency and open the door to activate quantum matter. Second, it will unravel the effects of quantum properties on the operation of motors, including the long-standing question of quantum Brownian motion. Third, autonomous quantum engines in the single-atom and many-body regimes will be realized and characterized as novel leading-edge platforms for experimental quantum thermodynamics, shedding light on nonequilibrium hybrid many-body states of matter, light, and mechanics.Thus, the project will open up a unique opportunity to experimentally investigate fundamental and applied questions of quantum thermodynamics, such as efficiency and sustainability issues at the quantum level, with high relevance for emerging quantum technologies. Furthermore, it will enormously impact frontier areas of solid-state simulations, quantum physics, and active matter, potentially establishing new research fields.


**Keyword
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Health and usage monitoring of aerospace structures using optical fibre bragg grating sensors' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The main objective of the research project is to investigate the potential of in-fibre Bragg grating (IFBG) strain sensors for health and usage monitoring of aerospace structures. The content of the research project is summarized below: i) Fabrication of in-fibre Bragg gratings using tuneable UV pulsed laser source. ii) Development of a signal processing technique to measure the strain and temperature induced change of the reflected wavelength. iii) Characterization of strain and temperature performance of gratings manufactured in (i) using the method developed in (ii) iv) Investigation of a novel technique to separate the temperature and strain response of the IFBG's v) Embedding of the IFBG's into composite materials and evaluation of the techniques developed in (iii) to measure strain using mechanical test machines. In addition to evaluate the temperature-strain separation technique under embedded conditions. The results expected form this research project will enable an assessment of the performance of in-fibre Bragg gratings as embedded strain sensors for composite structural health and usage monitoring with the major issue of temperature-strain cross-sensitivity investigated. The project will allow me to obtain training at an advanced level in the interdisciplinary high technology subject areas relevant to future industrial requirements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Certificatorio with mineral in tomato cherry, Solanum lycopersicum L., with interest for human nutrition'.

assistant: **Concept**

The role of human diet has been traditionally associated with the contribution of macro- (carbohydrates, lipids and proteins) and micronutrients (vitamins and minerals for the proper functioning of the body. In this regard, minerals are inorganic compounds that the body cannot produce on its own and for that reason they are considered essential. Its main functions in the body encompass from the constitution of skeletal structures such as bones and teeth to the contribution in the transmission of nerve impulses and muscle contraction, among other regulatory functions. The proper intake of this minerals is regulated by the recommended daily allowances (RDAs) which are defined as average daily level of intake sufficient to meet the nutrient requirements of nearly all (97-98%) healthy people. RDAs are established according to the necessity and requirements, taking into account the bioavailability, race and population groups to avoid deficiency diseases. The fruit and vegetables are of great importance due to their composition in bioactive compounds for instance minerals antioxidants vitamins and other bioactive compounds. For that reason, the interest of researchers and food companies in obtaining natural foods thoroughly consumed by population which influence in a positive way into the consumers’ health is increasing. Our company is seeking for a foreign Recognised Researcher (PhD holder or equivalent who are not yet fully independent) with expertise in nutritional aspects of crops, especially in biofortification tomatoes, according to the European Food Safety Authority (EFSA). The incorporation of Innovation Associate the research to promote better understanding and development of obtaining a new line of innovation, which will open a new market and thus obtaining a produc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'European initiative for a Citizen digital ID solution'.

assistant: **Innovation**

EUCLID aims at supporting the collaborative action initiated in the eEurope Smart Card Charter Trailblazer 1 (TB1) Public Identity". The goals of TB1 are to create a plan for European Citizen Digital ID and to elaborate minimal requirements and recommendations to make sure that electronic public ID tokens issued in the member states can be read and recognised in the other member states. Through a "Thematic Network" type of project, EUCLID will provide the support infrastructure and coordination required for an efficient collaboration of the TB1 member organisations. EUCLID will also provide the required information dissemination means to promote a common approach to the implementation of citizen digital ID in Europe and initiate the preparatory work for standardisation.OBJECTIVESEUCLID aims at supporting the creation of consensus on the implementation of citizen digital ID in Europe. It will Directly contribute to the priorities defined in the eEurope Smart Card Charter Action Plan. EUCLID will provide the leadership and the support infrastructure to carry out this initiative. It will also provide the resources and professional support for an awareness campaign to promote large adoption of common requirements in citizen digital ID by the Member states. The results of EUCLID will facilitate the deployment of e-government and e-commerce applications.DESCRIPTION OF WORKEUCLID project will be organised following the key requirements in a successful European collaboration:1. The creation of a favourable framework for cooperation and consensus making. This covers support for physical meetings but also remote cooperation of members through a Web tool designed for supporting a virtual community. It aims at supporting the community initially established in Trailblazer 1 "Public
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Serendipity in Research and Innovation' to be submitted under Horizon 2020.

assistant: **Abstract**

The focus of the SIRI project is on the desirability and feasibility of targeting research, and the idea of ""serendipity"" in research and innovation (SIRI). This is the notion that research leads to unexpected valuable outcomes and, since the outcomes of research are impossible to predict, research itself is difficult (perhaps even impossible) to manage or direct towards specific social ends. Research may be uncertain, but it is not random, and we know that industrial R&D managers fund research in areas where they expect returns and organise research to maximise its impact. With public policy, the scenario is slightly different, but there is limited evidence to draw on to support policy making. Thus, SIRI asks whether EU science can be better managed in ways that enhance the social and economic value of serendipity. The project will undertake a mix of fundamental basic research on the nature of serendipity and its measurement, its history and influence on research policy, together with applied policy-focused research on issues of direct relevance to government policy makers, medical charities and industrial R&D managers. It will deploy mixed quantitative and qualitative methods to generate large scale evidence as well detailed cases studies. It will then focus on developing theory and implications to inform future policy on research and innovation.""


**Keywords:** serendipity,  research policy,  science and technology policy,  biomedical innovation,  case study,  bibliometrics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Perceptual Mechanisms that Support Accent Accommodation' in the context of a Horizon Europe call.

assistant: **Objectives**

Understanding spoken language requires listeners to map complex acoustic input onto linguistic representations in their mental lexicons. The difficulty of this process is increased by variation in the acoustics of spoken language. In particular, variation in how second-language (L2) speakers produce the sounds of a language (i.e., ‘foreign’ accents) can hinder the efficiency of speech perception. Prior work has indicated that listeners are highly adaptable, and can rapidly accommodate unfamiliar variation in accented speech, but what remains unclear is how listeners rapidly adapt to accented talkers. Many authors have proposed that listeners may “tune” to accented speakers by shifting their phonemic category boundaries (phonemic recalibration). However, attempts to directly link phonemic recalibration to accommodation of natural L2 accents have resulted in mixed outcomes. An alternative perceptual mechanism that has been proposed for accent accommodation is criteria relaxation. On this view, when encountering an unfamiliar accent, listeners relax their thresholds for accepting input as a particular phoneme, lexical item, and so on. Relatedly, listeners may rely less on categorical boundaries when processing L2 accent.The primary aim of the proposed project is to improve our theoretical understanding of the perceptual mechanism(s) that support accent accommodation. In a series of three experiments, we will investigate the roles of phonemic recalibration and criteria relaxation using a combination of behavioral and psychophysiological measures. Specifically, our interdisciplinary approach will examine shifts in phonemic category boundaries and changes to within-category sensitivity, as well as the rate and cognitive demands of lexical activation for accented items. Ultima