RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Maximising the Exploitation of Linked Open Data In Enterprise and Science'.

assistant: **Innovation**

The European Open Data Strategy establishes important new principles that ensure that European public sector data will be released at no cost (or marginal cost), in machine-readable, commonly-understood formats, and with liberal licenses enabling wide reuse.  These data encompass both scientific data about the environment (from Earth Observation and other fields) and other public sector information, including diverse topics such as demographics, health and crime.  The intention of the Strategy is to stimulate the growth of research and value-adding services that build upon these data streams; however, researchers and industry are only just beginning to understand the benefits of exploiting Open Data and the value of combining previously-disparate sources of information.This project will develop eight new innovative and sustainable services, based upon Open Data, for users in research, government, industry and the general public.  A broad range of societal benefit areas are covered, including agriculture, urban ecosystems, land use management, marine information, desertification, crisis management and hydrology.  The long-term sustainability of the services will be assessed critically throughout the project from a number of angles in order to ensure that the full benefits of the project are realised in the long term. A comprehensive and coherent strategy of user engagement and dissemination will ensure that the project develops in response to real user needs.The project will provide the service developers with a collaborative technology platform that gives the computing capability required to handle and process such large and diverse datasets.  It will allow them to focus on the design and evolution of their service, enable collaboration on common tasks and will contribu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Augmenting the Value of Conversations with Voice Transformations'.

assistant: **Concept**

Project ACTIVATE aims to bring to market real-time voice-transformation technologies based on ERC CREAM's research in emotion neuroscience, which can augment the value of spoken conversations by adding business-relevant control on emotional expressivity. For instance, in the context of a call-center conversation, our real-time voice transformations may make an angry client’s voice 10% less aggressive, reducing employee fatigue at the end of the day, or make an operator’s voice 10% more trustworthy, augmenting customer satisfaction after the call. Project ACTIVATE will (1) conduct market analyses and interviews of industrial players to identify relevant conversational situations in which the technologies can be tested (e.g. for a call-center, a customer calling to resiliate their contract), (2) identify precise conversation outcomes that have market value (e.g. retention rate after the call), (3) measure the impact of the voice transformation on these outcomes in a simulated test environment that is near the desired configuration in terms of performance and user performance and (4) use the technology’s measured impact on relevant variables (e.g. a X% increase of retention rate) to estimate the value of a minimally-viable product (MVP), to be taken to market by a startup company to be created at the end of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Reactive Oxygen Species in CTL-mediated Cell Death: from Mechanism to Applications'.

assistant: **Concept**

Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells release granzyme and perforin from cytotoxic granules into the immune synapse to induce apoptosis of target cells that are either virus-infected or cancerous. Granzyme A activates a caspase-independent apoptotic pathway and induces mitochondrial damage characterized by superoxide anion production and loss of the mitochondrial transmembrane potential, without disrupting the integrity of the mitochondrial outer membrane; while causing single-stranded DNA damage. GzmB induces both caspase-dependent and caspase-independent cell death. In the caspase-dependent pathway, mitochondrial functions are altered as evidenced by the loss of mitochondrial transmembrane potential and the generation of reactive oxygen species (ROS). The mitochondrial outer membrane (MOM) is disrupted, resulting in the release of apoptogenic factors. To date, research on mitochondrial-dependent apoptosis has focused on mitochondrial outer membrane permeabilization (MOMP) however whether the generation of ROS is incidental or essential to the execution of apoptosis remains unclear. Like human GzmA, human GzmB promotes cell death in a ROS-dependent manner. Preliminary data suggest that human GzmB can induce ROS in a MOMP-independent manner as Bax and Bak double knockout MEF cells treated with human GzmB and perforin still display a robust ROS production and dye in an ROS-dependent manner. Since GzmA and GzmB induce cell death in a ROS-dependent manner, we hypothesize that oxygen free radicals are central to the execution of programmed cell death induced by the cytotoxic granules. Therefore, the goal of this proposal is to dissect the key molecular events triggered by ROS that lead to Citotoxic Tcell-induced target cell death. A combination of bioc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Crisis on the margins of the Byzantine Empire: A bio-archaeological project on resilience and collapse in early Christian development of the Negev Desert' (NEGEVBYZ).

assistant: **Innovation**

This project proposes an innovative, integrative and data-intensive approach to understand the parameters for long-term sustainable functioning of complex societies under vulnerable conditions. The broad aim of the research is to explore contexts of collapse and resilience in an ancient society with high levels of socio-political complexity and technological ingenuity within a resource-limited environment. It focuses on the Byzantine early Christian urban centres of the Negev Desert (4th-7th cent. AD) disclosing both the triumph of human ingenuity in conquering the desert through large-scale human settlement and agricultural development as well as a striking and as yet ambiguous case of wholesale systemic collapse. To test hypotheses regarding social disintegration, economic stress, environmental degradation due to climatic or anthropogenic causes, and the question of plague the project integrates approaches in the archaeology of households, landscapes and garbage through use of biomolecular, botanical, zoological, geological, chronometric, artifactual and contextual sources of data. Dealing with societal vulnerability in marginal regions is timely and relevant in a world where accelerating development rapidly expands such problems, previously localized, to global levels. Although it is a risky endeavour to engage the record of past societies to inform the present and forecast the future due to the typically underdetermined nature of historical and proxy data, this project offers substantial gain to theoretical and empirical research on societal vulnerability in two main avenues: (1) providing an opportunity to critically re-evaluate the current state of knowledge in the field based on an extensive corpus of new, high-quality data and (2) drawing more nuanced and inform
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Neuroregenerative peptide treatment for multiple sclerosis' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

REGENERA MS will assess the technical and commercial feasibility of a novel peptide as a superior treatment for multiple sclerosis (MS). Successful commercialization of our peptide could reduce the socioeconomic burden of MS, provide an early-therapy option to delay disease progression and thus extend and improve patients lives, with potential effectiveness in related neurodegenerative diseases. MS is a chronic inflammatory, autoimmune, and neurological disease without a cure, affecting the lives of 1.2M Europeans and causing significant economic costs to patients and society. Currently, there is no cure for MS. Approved disease-modifying treatments such as IFN-1, glatiramer acetate and alemtuzumab are clinically effective but come with high costs, significant side-effects, and intrusive administration. Thus, a medical unmet need remains for novel MS therapies that can halt progression, promote myelin repair and limit complications. To improve on the current therapeutic regimen, we propose a next-generation neurotrophic factor (NTF) therapy that has curative potential by halting MS progression and regenerating demyelinated tissue. My group has discovered a novel peptide with neurotrophic properties and which, in contrast to classical NTFs, (i) has neurorestorative effects and can enhance remyelination (ii) penetrates the blood-brain barrier (BBB), (iii) can be subcutaneously administered, and (iv) can be inexpensively produced. In REGENERA MS, we will evaluate the pharmacokinetic properties and efficacy of a novel therapeutic peptide in organotypic brain cultures, human induced oligodendrocyte-like pluripotent stem cell-derived cells and in MS animal models. Subsequently, we will verify the IP position and strategy, perform an in-depth market and competitor analysis, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Temporal reconstruction of tRNA abundance during cortical development in progenitor cells'.

assistant: **Objectives**

The cerebral cortex with its range of specialized excitatory projection neurons is essential to the high-order cognitive functions of the brain. These hundreds of subtypes of projection neurons arise from a uniform pool of multipotent apical progenitors (APs) which sequentially generate neuronal progeny with distinct fates over time.Recent technological advances in single cell transcriptomics revealed the existence transcriptional programs that seed neuronal diversity. While this working model provides a good explanation for the developmental origin of the distinct neuronal subtypes, it is flawed by the existence of some non-correlating mRNAs and proteins. Indeed, a significant fraction of mRNA that characterizes mature neurons can already be found untranslated in progenitors. The additional mechanisms that coordinate the protein synthesis and ensure correct protein expression in progenitors and daughter neurons have not been identified yet. This project focuses on solving the timely question of which mechanisms, synergically with transcription, are required to refine gene expression during neurodevelopment and cortical patterning.To do so, we explore the role of translation and its critical adaptor molecule, the transfer RNA (tRNA), in regulating the competency of APs to generate distinct neuronal fate during mouse embryonic cortices development. We will generate a comprehensive view of tRNAs abundance and translation efficiency in APs at ages E12 to E17. This will uncover a novel regulatory role for tRNAs, updating the conventional view of them as housekeeping genes, and find new candidate genes for cortical development in both health and disease. All in all, we will provide a new working model for how neuronal fate and diversity are regulated and opens avenues for fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mapping of Longitudinal data of Inequalities in Education' to be submitted under Horizon Europe.

assistant: **Abstract**

The MapIE project aims to identify mechanisms causing educational inequalities and policies or interventions compensating for them. We do a systematic review of how these have been studied internationally using longitudinal designs. We map existing longitudinal data that we describe in a public metadata database, and we analyse them to describe the mechanisms of inequalities and to identify effective policies and interventions in different local contexts. We focus on the contextual differences between the Nordic and Central European countries that have structurally different education systems. Within national contexts and using comparative research designs, we look at system-, regional- and school-level policies and practices and individual-level factors (e.g. socioeconomic status, immigrant background, gender, special educational needs) that are associated with the development of educational inequalities and the successful prevention of achievement gaps. We publish and disseminate the empirical results of the project through multiple channels to scientific audiences, policy makers and the wider public. At the end, we create a public framework for studying educational inequalities longitudinally in future studies, acknowledging the role of local contexts but aiming for comparability at the European level. We implement the project in seven work packages. Our consortium consists of internationally acknowledged experts in large-scale educational assessment research from Finland, Sweden, Norway, Hungary and Luxembourg/Germany. The partners have a long-standing history of collaboration with each other, European researchers, and national and international education policy makers, and they bring extensive longitudinal datasets to the project. The project will considerably stre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced Characterization of Organic-rich Shales using Vapour Adsorption', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The overarching goal of this proposal is to develop a novel experimental framework for quantifying the total specific surface area of organic matter and the wettability of pores in shales, and interpreting the displacement mechanism between gas and water by using a selective adsorption approach coupled with independent verified electron microscope measurements. The overarching goal of the project will be achieved through the following scientific objectives. First, a 3D structural model of the hydrophobic and hydrophilic site distribution in shales at around 50 nm resolution by combining FIB-SEM and high resolution TEM will be developed. This will provide an independent verification for later site-selective adsorption studies. Second, a vapour adsorption method by researching and verifying the most suitable probing vapours and the most reliable measuring approach will be developed. This will create a novel experimental framework for quantifying the total specific surface area of organic matter and the wettability of pores in shales, which will be verified by a previously-built 3D structural model. Last, the displacement mechanism between water and gas will be disclosed by determining the influence of hydrophobic and hydrophilic sites in shales using sequential adsorption and in situ NMR. This will be the essential theoretical part of the work for developing next generation enhanced gas recovery techniques through non-aqueous fluid injection and heat stimulation. The outputs of this project will disclose the chemical/wetting nature of pore systems in shales, which will be essential for improving current fluid transport models in shales by considering surface chemistry properties and developing the next generation of environmentally-friendly shale gas recovery technology t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'GMSPAZIO Satellite Tracking Toolkit' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

GMSPAZIO Satellite Tracking Toolkit (GSTT) helps satellite owners to successfully manage Space Situational Awareness.GSTT helps the users to steer a satellite platform to a safer position avoiding collisions and extending expected lifetime cyclewith more accurate and precise manoeuvres while reducing costs and delivery time, by using the system Planning,Scheduling, Acquisition and Data Processing features. GSTT measurements applied to manage GEO space platforms givesatellite owners the capability to assess real platform position with a maximum margin of error of 20 meters. GSTT is aground-breaking innovation capable to make a major contribution to the maintenance and safety of European strategicassets such as GALILEO constellation. The TRL of GTSS is Level 8 (system complete and qualified): an specific version ofGSTT named GMSPAZIO Satellite Awareness Toolkit is fully operational at an Italian Ministry of Defence site sinceDecember 2012.The project specific objectives are to study the product process of industrialization -from an operational prototype to anindustrialized system- in order to make it available to the market as a customized turnkey solution; to study the Market –identifying the main competitors, potential risks, Marketing strategies and Pricing & Distribution policies - to support GSTTcommercialization and to design a Business Plan with 5-year projection (income statements, balance sheet and cash flowstatements) based on reliable and cautious assumptions in order to demonstrate the significant return on investment atEuropean level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'BIOINFORMATICS for the Functional Analysis of Mammalian 2001 - 2002', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Bioinformatics provides the key to the interpretation and exploration of massive amounts of data stemming from various genome projects. It requires an interdisciplinary and collaborative effort to cope with the needs of the present and future genome based research. Training young researchers in this field makes it necessary to present a broad spectrum of topics. This spectrum covers sequence and structure data analysis and includes such diverse areas as expression analysis, proteomics, comparative and functional genomics, metaboic and functional networks, algorithmics and complexity, knowledge presentation and data mining. A European effort to develop training programmes in the fled of genetics requires a strong support for bioinformatics and the availability of training structures where both students and Faculty members will exchange ideas and strategies to be integrated into an interdiscipinary background. While at present bioinformaticians represent an indispensable human resource for biomedical research, whose training has to be strongly promoted in Europe, at the same time biologists, biochemists and physicians must learn to apply bioinformatics as a problem solving tool.In order to help filling this gap, the EGF proposes a training course specifically aimed at bioinformatics. The traditional format of the scientific and training activities developed over the years in Sestri Levante consists of plenary lectures which are given during the morning and concurrent workshops during the afternoon. These are interactive group discussions between 10-15 students and one-two Faculty members on a speciaised topic of research. There are two rounds of 6-7 concurrent workshops every afternoon and faculty are asked to give, in addition to one lecture in a plenary session, one or