RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Developing geothermal and renewable energy projects by mitigating their risks.'.

assistant: **Objectives**

Geothermal project development has several risky components, the most important one being the resource risk. This concerns mainly deep geothermal projects, but some shallow geothermal open systems could also be included in this category of projects. Beyond exploration, the bankability of a geothermal project is threatened by this geological risk. The geological risk includes: - The short-term risk of not finding an economically sustainable geothermal resource after drilling;  - The long-term risk of the geothermal resource naturally depleting rendering its exploitation economically unprofitable. Until the first borehole has been drilled into the geothermal reservoir, developers cannot be sure about the exact parameters (temperature and flow rate) of the planned geothermal electricity or h&c project. Once drilling has taken place, in situ pump tests, temperature and hydrological measurements then reduce the resource risk and make it possible to attract external capital.  Risk insurance Funds for the geological risk already exist in some European countries (France, Germany, Iceland, The Netherlands, Denmark and Switzerland). The geological risk is a common issue all over Europe.  With the notable exception of these six countries, project developers have very little capability to manage this financial risk.  GEORISK project will work to establish such risk insurance all over Europe and in some key target third countries to cover the exploration phase and the first drilling (test). It means activities to be funded before financial institutions and IPP funding the confirmation drilling and surface systems. It appears clear that a risk mitigation scheme must be designed according to the market maturity of the sector.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Genotype-To-Phenotype Databases: A Holistic Solution' (GEN2PHEN) targeting Seventh Framework.

assistant: **Abstract**

The GEN2PHEN project aims to unify human and model organism genetic variation databases towards increasingly holistic views into Genotype-To-Phenotype (G2P) data, and to link this system into other biomedical knowledge sources via genome browser functionality. The project will establish the technological building-blocks needed for the evolution of today’s diverse G2P databases into a future seamless G2P biomedical knowledge environment. The project will then utilise these elements to construct an operational first-version of that knowledge environment, by the projects end. This will consist of a European-centred but globally-networked hierarchy of bioinformatics GRID-linked databases, tools and standards, all tied into the Ensembl genome browser. The project has the following specific objectives: 1) To analyse the G2P field and thus determine emerging needs and practices; 2) To develop key standards for the G2P database field; 3) To create generic database components, services, and integration infrastructures for the G2P database domain; 4) To create search modalities and data presentation solutions for G2P knowledge; 5) To facilitate the process of populating G2P databases; 6) To build a major G2P internet portal; 7) To deploy GEN2PHEN solutions to the community; 8) To address system durability and long-term financing; 9) To undertake a whole-system utility and validation pilot study GEN2PHEN Consortium members have been selected from a talented pool of European research groups and companies that are interested in the G2P database challenge. Additionally, a few non-EU participants have been included to bring extra capabilities to the initiative. The final constellation is characterised by broad and proven competence, a network of established working relationships, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Mercury Emissions Control (MEC) technology to enable thorough assessment of combustion and waste incineration plants to meet upcoming legislation directives for the reduction of mercury emissions'.

assistant: **Innovation**

Mercury emissions created during industrial processes are one of the most harmful pollutants, causing neurotoxic effects in humans and animals. Upcoming changes to EU Industrial Emission Directives are set to reduce mercury levels over the coming years with a plan to eventually eliminate mercury emissions entirely. The largest emitters of mercury are our target markets coal-fired power plants, waste incineration and all combustion plants (cement, chemical industry, etc.), are required to retrofit costly solution technologies to meet limit values. But, identifying the most applicable mercury reducing solution for each individual plant is an industry challenge since there is no ‘one-size fits all’ solution due to varying fuel composition, technology mix and plant configuration at each individual plant.Building on our globally unique know-how for measuring, controlling, regulating and optimising feedstock, we have developed MEC, a unique mobile mercury testing facility that enables us to offer our clients a site specific solution with our further innovative plant technology. Our revolutionary new systems accurately measure mercury content and distribution in the flue gas duct. Subsequently, a significant reduction of the mercury content takes place using our new innovative processes and plants.Having proven TRL6, our objectives during this Horizon 2020 project are to finalise the MEC technology and prove to our target markets that MEC is a viable means of delivering an effective combined solution for efficient mercury emissions detection and reduction. We expect for MEC advancements to the SOA to enable us to meet our company objective to become a leading European player for mercury emissions detection and control.It is key for us to plan our market entry strategy carefull
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Linking research organisations in the fields of Tissue Engineering and Regenerative Medicine through European cooperation between regional research clusters', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The development of innovative 'Advanced Therapies' offers new approaches to tackle major diseases such as cancer, diabetes, Alzheimer or Parkinson. The progress made in the fields of 'Tissue Engineering' and 'Regenerative Medicine' (TERM) promises to deliver long awaited new solutions. They are recognized as potential sources for medical progress and significant economic growth where Europe should position itself.Since advanced therapies are often based on personalized medicine, the translation of medical developments into real-life, sustainable therapies is challenged by several hurtles. We need new scientific (multi-disciplinary, GMP-conform research environment), economic (new business models for high-cost-low frequency treatments) and structural (translation-oriented RTD) solutions. Europe has to improve its research capacities and accelerate translation to catch up with the US and keep ahead of rapidly developing Asian countries.TERM project aims at a consolidating skills and infrastructures among European regions and their research clusters through the definition of joint actions and mentoring. The goal is to derive high potential, translation-oriented projects from joining skill-sets, infrastructures and networks and from recognizing the requirements of the market forces. The financing situation shall also be analyzed and adapted to the requirements.TERM project will develop knowledge and strategies on how to use resources of the regions and clusters more efficiently with more synergy and focus. The knowledge generated shall be used to develop tools to efficiently assess the research potential of a region, implement best practices in a research cluster, develop inter-regional programs with joined research goals and suggest financial instruments that support these
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Reactive Oxygen Species and Hypothalamic Glucose Sensitive Neurons: a new mechanism in glucose homeostasis' to be submitted under Seventh Framework.

assistant: **Abstract**

Development of obesity and diabetes is the consequence of impaired glucose homeostasis regulation. The hypothalamic area of the brain and more precisely the arcuate nucleus (ARC) plays a critical role in this regulation. The ARC detects changes in blood glucose level and triggers appropriate physiological responses. For instance, increased brain glucose level increases insulin secretion and decreases food intake. Different populations of glucose sensitive neurons have been characterize in the ARC. Glucose excited (GE) neurons increase their electrical activity when extracellular glucose level rises from 2.5 to 5 mM, 2.5 mM being the physiological basal brain glucose level. By analogy, high-glucose excited (HGE) neurons increase their activity as glucose levels rises above 5 mM. Despite being studied by many groups, the molecular mechanisms and physiological roles of GE and HGE neurons are not fully understood.Preliminary work suggests that ARC mitochondrial reactive oxygen species (mROS) production is involved in glucose homeostasis. We showed that inhibition of ARC mROS production impairs increased brain glucose level-induced insulin secretion and food intake inhibition. We hypothesize that mROS production is involved in GE and/or HGE neurons glucose sensitivity. Four specific aims will test our hypothesis. Specific Aim 1 will determine whether ARC GE and/or HGE neurons produce mROS in response to increased glucose level and. Specific Aim 2 and 3 will determine whether whether mROS are involved in ARC GE and HGE neurons glucose sensitivity. Finally, Specific Aim 4 will determine whether ARC HGE neurons are involved in glucose homeostasis.This project is highly original and innovative in regards of the hypothesis proposed and technical strategies used. Understanding mol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'High-throughput screening, synthesis and characterization of active materials for flow batteries' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

PREDICTOR aims to establish a rapid, high-throughput method to identify and develop materials for electrochemical energy storage. This method will comprise:•A modelling and simulation tool for the computational screening of organic chemicals based on their potential performance in energy storage systems.•Automated chemical synthesis, electrolyte production and characterization methods, so that the chemicals identified in the screening step can be rapidly produced and tested for their suitability in energy storage applications.•Artificial-intelligence-based self-optimization methods that allow experimental data from material characterization to be fed back into automated experimental methods to enable self-driving laboratory laboratory platforms and for modelling and simulation tools, improving their accuracy.•Data management systems to standardize and store the data generated for further use in model validation and self-optimization proceduresThis approach will allow the rapid identification, synthesis and characterization of materials within a coherent development chain, replacing conventional trial-and-error developments. It will exploit the synergies between several emerging markets (digital technologies, artificial intelligence, high-throughput experimentation, renewable energy storage), providing the recruited doctoral candidates (DCs) with a valuable interdisciplinary skill set. To validate the PREDICTOR system, the case study will be active materials and electrolytes for redox-flow batteries. Within the project, three demonstrator battery cells (TRL3-4) will be assembled and tested with the newly developed materials.


**Keywords:** redox flow batteries, electrochemical energy storage, high-throughput, experimentation, modeling, simulation, automation, laboratory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Virus related biomarkers to improve management of chronic conditions' in the context of a Horizon Europe call.

assistant: **Objectives**

The unifying aim of VIROMARKERS is to define virus related biomarkers to improve management of chronic diseases, including biomarkers of response to antiviral treatment of persistent viral infections and virome features as indicators of disease progression in immunosuppressed people. The project has the following objectives:1.To demonstrate a novel bioinformatics method for prediction of HIV-1 susceptibility to broadly neutralising antibodies based on the HIV-1 gp120 sequence.2.To demonstrate novel HDV biomarkers (HDV-RNA, HBsAg isoforms and HDV genotype) to predict treatment response to the recently approved anti-HDV bulevirtide.3.To validate serum CMV-RNA as a biomarker of CMV infection/reactivation to optimise the correct timing for preventive strategies in patients undergoing hematopoietic stem cell transplantation. 4.To validate the torque teno virus DNA as a prognostic biomarker for CMV disease in immunocompromised patients. 5.To validate total and intact cellular HIV DNA as a biomarker of HIV infection status to guide novel antiviral strategies.Validation or demonstration of several technologies required to measure the candidate biomarkers is an integral part of the project objectives. In particular, this refers to the following diagnostic tools:•dPCR as a tool for HDV quantification •NGS platform for HDV sequencing •qPCR diagnostics for CMV-RNA quantification •IPDA suitable for detection of intact HIV-DNA in any viral subtype •qPCR diagnostics for TTV-DNA Leveraging on the regulatory expertise present in the consortium, VIROMARKERS will define the regulatory pathway for each of its outcomes and will generate the experimental data necessary to move prototype methods and tools to regulatory approval.Overall, VIROMARKERS, with its public private partnership nature,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Quantifying cell dynamics in myelopoiesis during immune responses' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Although changes in immune blood cell number is commonly used as a sign of infection or inflammation in the clinics, the cell dynamics parameters controlling cell numbers during an immune response (division, differentiation, and death) are not well understood. As myeloid cells are short lived, changes in myeloid cell numbers comes from cell production by myelopoiesis. Given the importance of cell dynamics in immune response, we propose to unravel the cell dynamics of myelopoiesis during inflammation. However, few methods allow to measure in vivo the cell dynamics parameters. Methods to study division in vivo can trace up 10 divisions, apart for the telomere measures that have no maximum but is restricted to cell types without telomerase activity, unlike our cells of interest. As we estimate a minimum of 14 divisions from hematopoietic stem cells to myeloid cells, a new method to follow over 10 divisions is required. This proposal will overcome this methodological barrier by developing the DivCounter a new method, to count division in vivo in mice. Our innovation is: 1/ to implement a quantitative counter of division combining wet and dry lab. 2/ compatible with single cell transcriptomics to measure cell differentiation status with the required granularity. 3/ creating a new mouse model. Using the DivCounter, we will quantify for the first time the number of divisions in homeostatic myelopoiesis. We will also infer division, differentiation and death rate, uncovering the understudied role of death in myelopoiesis. We will also unravel how division and death change during emergency myelopoiesis and when and how myelopoiesis returns to homeostasis after inflammatory stimulations. This knowledge will shed light on which of the cell dynamics parameters to intervene to chang
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Crop Production in the Levant and International Trade Exchange: investigating coprolites and crop plant remains from the 1st millennium CE Negev Highlands and Aravah Valley' in the context of a Horizon 2020 call.

assistant: **Objectives**

CroProLITE aims to evaluate the Islamic Green Revolution (IGR) thesis–involving crop introduction from eastern and central Asia to the Mediterranean by Early Islamic empires–through a microregional comparative study of 1st millennium CE agropastoral change. It applies archaeobotanical and biomolecular methods to numerous well-preserved plant macrofossils and herbivore dung pellets from rubbish dumps at nine Roman-Early Islamic trading sites in the Aravah valley on the southern border of modern Israel-Jordan and the adjacent Negev Highlands. Some sites are associated with Early Islamic agrotechnological introduction of qanat irrigation, indicating likely Early Islamic crop introduction there. Capitalizing on similarity of archaeological context alongside dissimilarity of historic-economic context, the comparative method will be applied to these regions and periods. To identify seasonal agropastoral rhythms, an extensive and innovative multi-proxy methodological study will analyse contents of ancient dung pellets from the sites. New datasets generated from plant remains and coprolites will allow synthesis of agropastoral developments at seasonal to millennial scales and framing of findings in terms of ancient economic history and Mediterranean deep history. Lessons on agricultural continuity and change from the Negev-Aravah in the face of first millennium CE global climate change, plague and cultural conflict hold promise for improved understanding of historical effects of environmental stressors. In unearthing such lessons, CroProLITE will contribute to long-term environmental risk assessment and reflection on our own society’s future, offering a model for environmental humanities research.Host supervisor and leading palaeoproteomics scholar Matthew Collins will guide bi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Quantum communication networks'.

assistant: **Concept**

My goal is to overcome the two-most pressing theoretical challenges necessary to build large-scale quantum communication networks: routing and designing protocols that use them to solve useful tasks. In two interconnected projects, I will devise entirely new concepts, models and mathematical methods that take into account the intricacies of real world quantum devices that can operate on only very few quantum bits at a time.(1) Security: I will prove the security of quantum cryptographic protocols under realistic conditions, and implement them in collaboration with experimentalists. I will develop a general theory and practical tests for the security of multi-party cryptographic primitives using untrusted quantum devices. This is mathematically challenging due to the possibility of entanglement between the devices.(2) Routing: I will initiate the systematic study of effective routing in a quantum communication network. This is necessary for quantum networks to grow in scale. Quantum entanglement offers very different means of routing messages than is possible in classical networks, and poses genuinely new challenges to computer science. I will design routing protocols in a multi-node quantum network of potentially different physical implementations, i.e., hybrid networks, that will establish a new line of research in my field. Quantum networks are still in their infancy, even though quantum communication offers unparalleled advantages that are provably impossible using classical communication. Building a quantum network is an interdisciplinary effort bringing together computer science, physics, and engineering. I am in a unique position in computer science, since I have recently joined QuTech where I have direct access to small quantum devices - bringing me tantalizingly