RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Protecting biodiversity through the development of environmentally sustainable locust and grasshopper control' under Fifth Framework.

assistant: **Concept**

The design and construction of binuclear copper centre based biosensors and biocatalysts are the two objectives of this project. Toward these aims we propose to investigate the molecular basis of reversible oxygen binding and activation as observed in the active site of structurally homologous binuclear copper proteins that physiologically function either as oxygen carrier or as selective monooxygenases and catechu oxidises. The objectives will be achieved by inclusion of these proteins into optically and chemically inert solid matrices. This will allow our industrial partners to construct a low cost optical oxygen biosensor for biomedical use and will provide a selective, removable biocatalyst for the conversion of endogenous phenol substrates in food processing. The available genetically engineered systems will allow for the tailoring of sensitivity and specificity of the proteins used to the implementation demands.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Research Advisors in action, NCP cooperation for excellence' to be submitted under Horizon Europe.

assistant: **Abstract**

The Marie Skłodowska-Curie Actions (MSCA), the EU’s flagship funding programme for researcher training, are complex and highly competitive within Horizon Europe. MSCA National Contact Points (NCPs) face numerous calls and applicants, which is particularly challenging for newcomers, widening, and third-country NCPs. RADIANCE aims to enhance transnational cooperation among MSCA NCPs and professionalize their services across Europe, with a focus on widening and third countries. The project will improve MSCA support services through targeted tools, training, and resources, ensuring consistency across Europe and beyond. RADIANCE aligns with the call's scope by boosting researcher coaching quality, equipping over 160 MSCA NCPs with tailored tools to better advise the scientific community. The project combines innovative tools like AI with traditional methods, offering activities such as benchmarking, workshops, brokerage events, training, twinning, mentoring, and self-guided learning, supported by a personal skills development plan, documents, videos, and e-learning material. It strengthens research capacity by supporting MSCA NCPs, facilitators, the scientific community (especially in widening and third countries), and stakeholders like the European Commission (EC), the Research Executive Agency (REA) and the Marie Curie Alumni Association (MCAA) through mutual knowledge transfer and collaboration. We also foster synergies with various initiatives, such as Euraxess or the Horizon Academy with a focus on long-term sustainability of the project’s impact. RADIANCE will achieve its goals through five Work Packages (WPs): WP1 (Coordination and Communication), WP2 (Capacity Building), WP3 (Project Life Cycle), WP4 (Digital Tools), and WP5 (Synergies and Support to widening and thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'FROM SINGLE MOLECULES TO CELL REPROGRAMMING: DECIPHERING AND RECODING DISORDERED PIONEER TRANSCRIPTION  FACTORS'.

assistant: **Concept**

Pioneer transcription factors (pTFs) have unique capabilities beyond classical TFs: They can invade and open closed chromatin, initiating cell-fate changes. Their remarkable abilities have been used to steer cell-fate decisions and to induce a pluripotent stem cell state through poorly understood pathways. Like most TFs, pTFs consist of structured DNA-binding domains (DBDs) flanked by long intrinsically disordered regions (IDRs). In attempts to explain their pioneering functions, intense focus has been on how the structured DBDs of pTFs interact with the nucleosome core particle. Yet, the critical interactions with nucleosomes beyond the core particle, the interplay between DBDs and IDRs, and the molecular mechanism of chromatin invading and opening, remain unclear.The extensive disorder of pTFs places them outside the scope of current structural biology efforts and understanding their functions therefore requires a different approach. Single-molecule spectroscopy offers a powerful toolbox to monitor dynamic molecular systems and measure their conformational distributions. These methods enable quantitative modeling of distances and dynamics in biomolecules over timescales reaching over 15 orders of magnitude. Building on our recent breakthroughs in single-molecule techniques for studying highly disordered proteins in chromatin regulation and our preliminary data on pTF IDRs, we are in a unique position to apply our expertise to the molecular mechanism of pTFs. Using five established pTFs involved in four distinct cell reprogramming pathways, we intend to: 1) map conformational states, 2) decipher kinetic mechanisms, 3) engineer new pTFs, and 4) observe chromatin remodelling, both in vitro and within the complex cellular environment. A molecular-level understanding of pT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of a wrist orthotic device for tremor suppression through biomechanical loading by means of a novel rotary actuator' (TREM-END) under Seventh Framework.

assistant: **Objectives**

In the EU more than 4.25M people aged 40 and over are affected by Essential Tremor (ET), a progressive neurological disorder whose most recognizable feature is a tremor of the arms that is apparent during voluntary movements. ET affects the hand in 90% of the cases and, consequently, everyday tasks and those requiring fine motor skills (such as eating and writing) become very difficult for the patients, and this drastically decreases their quality of life (QoL). Medication and surgical interventions are currently employed to reduce tremor in patients suffering from ET. However, both present poor outcomes and, besides being very expensive, both can result in side effects, the major part of which are very debilitating for the patient (e.g. drowsiness, toxic reactions, permanent complications, etc.). As a result of the current poor outcomes, treating patients with ET is still an unsolved problem that drastically affects the Activities of Daily Living (ADLs) and the QoL of approximately 2M European people. During the last years, scientific publications have shown that ET responds to biomechanical loading. It has been clinically proven that the increase of dumping and/or inertia in the upper limb leads to a reduction of the tremorous motion, and this led to the development of experimental wearable devices for tremor suppression (orthoses). However, existing concept solutions still present reduced performance and several limitations such as obtrusiveness, weight, and low acceptance among users that have prevented their development as a commercial product. The aim of the Trem-End project is to develop an innovative commercial orthesis for tremor suppression at wrist of patients resistant to conventional treatments, and which will be cost effective compared with current solutio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of Effective Vaccines against Multiple Lifecycle Stages of Plasmodium vivax malaria' (MultiViVax) under Horizon 2020.

assistant: **Objectives**

Plasmodium vivax is the most widespread malaria and constitutes a significant proportion of human malaria cases. P. vivax accounts for 100-400 million clinical cases each year among the 2.5 billion people living at risk in Latin America, Oceania and Asia. The recently revised Malaria Vaccine Technology Roadmap to 2030 recognises the severity of P. vivax malaria and calls for a vaccine intervention to achieve 75% efficacy over two years – equally weighted with P. falciparum. However, despite this global health need, efforts to develop interventions against this parasite have lagged far behind those for P. falciparum, in large part because of critical bottlenecks in the vaccine development process. These include i) lack of assays to prioritise and down-select new vaccines due to lack of an in vitro P. vivax long-term culture system, and ii) lack of easy access to a safe controlled human malaria infection (CHMI) model to provide an early indication of vaccine efficacy in humans. The Objectives of this MultiViVax proposal will address these critical bottlenecks and shift the “risk curve” in order to better select successful vaccine candidates against multiple lifecycle stages of P. vivax: 1. We will establish a P. vivax CHMI model in Europe for the first time to facilitate the better selection of effective vaccines and remove the current bottleneck for their early-phase clinical testing.2. We will utilise this CHMI model to identify novel antigens associated with protective blood-stage immunity in humans by taking advantage of recent advances in immuno-screening and parasite RNASeq.3. We will progress existing vaccines targeting the current leading antigens for both the blood- and transmission-stages along the clinical development pipeline.4. We will develop novel transgeni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Learning in single cells through dynamical internal representations' under Horizon Europe.

assistant: **Concept**

Cells continuously sense and interpret the external signals coming from their time-varying environments to generate context-dependent responses. This is true for the entire tree of life, ranging from bacteria and unicellular eukaryotes to neurons forming networks in the developing brain. Identifying the fundamental principles and underlying mechanisms that enable cells to interpret their complex natural surroundings and adequately respond remains one of the fundamental questions in biology. Conceptual views so far have been mainly guided by molecular biology descriptions, suggesting that cells are controlled by a genomic program executing a pre-scripted plan. Our goal is to develop an alternative conceptual framework: cells generate internal representations of their external ‘world’, which they utilise to actively infer information about it and predict changes, in order to determine their response. We will formalise this concept in a theory of single-cell learning, by combining information theory concepts to quantify the predictive information from the internal cell representations, with dynamical systems theory to explain how these encodings are realised. We will interrogate experimentally systems across all scales of biological organization: bacteria (B. subtilis), single-cell organisms (Paramecium, Tetrahymena) and neuronal cell culture models. By studying them in a comparative manner, we aim at identifying generic molecular mechanisms through which single-cell learning is realised. The acquired understanding will enable us to address in vivo how single neurons during D. melanogaster development learn to form, stabilize or eliminate axonal branches, to generate stereotyped synaptic patterning under highly-variable conditions. We argue that providing a broader and gen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sonic migrations: Congolese rumba and utopias in 20th century West Central Africa' (CONGOTOPIA) targeting Horizon 2020.

assistant: **Abstract**

CONGOTOPIA proposes a new approach to the historical phenomenon of decolonization. Built on a rich bibliography in history, anthropology and sound studies, this project examines the movement of people, ideas and music put into motion by the Pan-African appeal of Congolese rumba. Inspired by early Afro-Cuban records, this dance music emerged in 1940s Leopoldville (current-day Kinshasa) and Brazzaville and soon became Africa’s most influential popular style  thanks to the development—unique to Africa—of local radio stations and recording companies. Across different territories yearning for their independence, Congolese sound inaugurated a utopic Africa, audible over various Afro-Cuban rhythms and multi-voiced harmonies mixing Spanish with various African languages. While closely associated with pleasure, romance and fantasy, this popular music became a powerful marker of decolonization—in the 1960s, it “inflamed”  Angolan nationalists’ spirit during the liberation war while allowing great Brussels-based musicians such as Manu Dibango to “jump in feet first with the question of Africa.” Examining the global, trans-imperial geography of Congolese rumba between Cuba, West Central Africa and Europe will reframe the conception of decolonization and the movements through which it unfolded in the period 1930-1974. By straddling the traditional divide between Francophone and Portuguese territories while reconnecting the African continent to the Southern Atlantic, it challenges established approaches to decolonization and sheds light on the history of a space (West central Africa) and from a perspective (colonized people’s) that have long been marginalized in the field of African studies. As the Congo(s) and Angola are impossible to fully dissociated from their multi-layered relat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Witten's conjecture in K-theory' (HSCWTCC).

assistant: **Innovation**

In this proposal we present a project in Algebraic Geometry with connections to TheoreticalPhysics. The applicant, Alessandro Chiodo, is an Italian researcher completing (June 2003) his Ph.D.at DPMMS, University of Cambridge, UK. The host institution is the Laboratoire Dieudonné(University of Nice - Sophia Antipolis), the largest research group in complex algebraic geometry in France. The main objective is to contribute to a set of conjectures by Edward Witten relating moduli of curves with integrable hierarchies relevant to String Theory and Quantum Field Theory. The method aims to achieve further results on the conjectures by lifting them from Chow rings toK-rings. The method is likely to succeed because the approach in K-theory contributed to the conjecture already in the applicant's Ph.D. Thesis. Several new techniques related to K-theory are involved and research training in these fields plays a key role for the success of the project. Research training is also beneficial to the applicant's planned career. The complementary skills (stacks, DG-schemes etc.) involved here are modern tools in Algebraic Geometry, rarely taught in European universities. Therefore this Marie-Curie fellowship will strongly enhance the applicant's possibilities to become an independent scientist with a permanent job in an Italian or other European university.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The evolutionary genetics of transposable element invasions' in the context of a Horizon 2020 call.

assistant: **Objectives**

Transposable elements play major roles in the genome evolution of eukaryotes, and cause harmful mutations, deleterious side effects, and disease. These costs drive their eukaryotic hosts to evolve counter-adaptations, which are so effective that TEs are thought to only survive long term by invading new naïve species. These transposable element invasions appear to occur via horizontal transfer, and can result in the rapid, selfish spread of the element through a species.  Despite the evolutionary importance of the host-transposable element relationship, there are still major gaps in our knowledge of how they evolve and persist. Host resistance can evolve astonishingly rapidly, but the evolutionary mechanism by which this happens is unknown. Some horizontal transfer events result in successful invasions, but we have little idea of what factors favour success, or, except in rare cases, how the transfer events occur.  This proposal outlines a four-part research programme to address these gaps, examining both sides of the coevolutionary equation. Specifically, I will examine the rapid evolution of suppression from the host side, to understand the population genetics of this process.  I will study invasions from the perspective of the transposable element, and ask what genetic factors contribute to their success. To accomplish these objectives, I will take advantage of a unique opportunity-- an ongoing invasion of a model transposable element in a close relative of the genetic model fly. Finally, I will examine the role of parasites as vectors of TEs ,to understand  mechanisms of horizontal transfer between species.


**Keywords:** transposable elements, Drosophila
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'To COMFORT VTS - Management' (COMFORTABLE) under Fourth Framework.

assistant: **Objectives**

Task 27/01: To develop tools for VTS operators for the recognition and assessment of traffic situationsTask 27/02: To develop a support system that can assist a VTS-operatorTo combine different kinds of approaches in various VTS-areasTo combine the VTS situation traffic display (Collission Risk Approach) To develop the algorithmus which will form the basis for the potential implementation of new or enhanced VTSTo provide the theoretical background to support operators of VTS-systemsTask 27/03 :To find out methods of mathematical representation of manoeuvering characteristicsTask 27/04 :To investigate the integration of ECDIS/ENC into VTSTask 27/05 :(Traffic Displays) To deliver a report on operational requirements w.r.t. VTS traffic displays and its MMI leading to a support system for VTS-operators(Traffic Situation Display) To develop a traffic situation display for VTS(Dense Traffic, PORT & APPROACH) To fit modern maritime traffic control requirements with efficient MMI and advanced track recognition functionsTask 27/06 :(Dense traffic offshore) To develop a concept and to design a Traffic Density Detector operator tool(Traffic situation display) To aid VTS operators to enhance safety and efficiencyTask 27/07 (Traffic Situation Display) :To improve traffic situation assessment and/or tactical assistanceTask 27/08 (MATIAS PROJECT)To develop, implement, assess and demonstrate processing methods to predict traffic image in a regional areaTask 27/09 (DATA LINKS & DATA)To define means, interfaces and procedures to allow for standardized automatic data exchange between VT and main linksTask 27/10 (Consortium Management)A joint coordination of INCARNATION, COMFORTABLE and MASSTER through the COMFORT consortium %Testbeds at VTS stations %A close cooperation within the COMFORT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Innovative designs to enable plastic packaging circular economy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Plastics are the material of choice in packaging applications because of their low cost, high performance and ready processability. Such is their success that it is expected that by 2050 the production of plastic packaging will exceed 250 million metric tons. Considering most plastics that are employed in the packaging industry are used for less than a week, the lack of environmental degradability has led to a tremendous growth of disposed plastics. This growth, together with the fact that the vast majority of synthetic plastics are designed for performance and durability and not for degradability and recyclability, has brought tons of plastic accumulation in the oceans and landfills - ~56 million tons per year. The problem has been highlighted by the acclaimed prediction that by 2050, the ocean is expected to contain more plastics than fish (by weight). Although it was envisioned that biodegradable polymers based on ester linkages such as poly(lactide) (PLA) or poly(3-hydroxybutyrate) could be part of the solution because they are mainly derived from biorenewable sources (e.g. starch and cellulose) and can be enzymatically or hydrolytically degraded leading to an environmentally closed circular ecosystem, the low permeability in the case of PLLA and the poor mechanical properties in the case of PHB has limited their potential. NATURE-EID proposes an innovative research training program at the forefront of circular economy of biobased polyesters. In particular, the project will develop fundamental knowledge in the synthesis of new biobased polymeric materials where the polymers are not only design based on their performance but also on their recyclability.


**Keywords:** Biobased polyesters, polymeric materials, recyclability, sustainable polymerization processes