RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'At the fringes of the Republic of Scientists: the East-West routes of scientific communication in Europe in the age of experiment (1650-1680)'.

assistant: **Innovation**

Eastways of Science aims to carry on and to improve Highways of Science, the project the researcher worked at thanks to a Marie Curie Intra-European Fellowship at the Centre A. Koyré in Paris from July 2005 to June 2007. Highways of Science meant to construct a prototype of a multitask data-base user-friendly, that takes into account evidence gathered from scientific and learned correspondences (personal biographies, scientific institutions, instruments, natural specimina and objects, places related to scientific practices) so as to define and highlight the contents, the networks and the ways of transmission of cultural and scientific information in early modern Europe. Eastways of Science aims to extend Highways of Science in two different respects. As to space, because it takes into account the so called «fringes» of the «Republic of letters»: the Mitteleuropa areas, especially Poland and the Habsburg Empire’s «periphery» (Bohemia, Moravia, Hungary and Rumania). As to time, because it looks further at the second half of the 17th century, the age when the experiment became the knowledge basis of modern natural philosophy. Most of all, Eastways of Science project means to climb over Highways of Science limits and difficulties by creating an electronic platform, an on-line interactive environment XML-based, that for the first time applies the Web2 system resources to an electronic archive of scientific-historical interest. In this case too, information will be arranged and available in a spatial and geographical fashion, so as to construct a map of the information fluxes in the western European cultural space, following the model of a traffic stream visualized on a luminous screen. The researcher and the University of Rome La Sapienza purpose to cooperate with the projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Copy Number Variation and Endophenotypes in Psychiatric Disorders' (PSYCHGENE).

assistant: **Concept**

A genome-wide copy number variant (CNV) association study for schizophrenia (SZ), bipolar disorder (BP) and major depression (MD) will be conducted at deCODE genetics using a discovery sample of 2400 affected (800 SZ, 600 BP, 1,000 MD) and 20,000 controls. CNV data will be generated from the newly released HumanCNV370-Duo array designed by deCODE genetics and Illumina. In this array there are about 55,000 probes covering known and supsected CNV regions. Algorithms for data analysis are being developed at deCODE. Employees from the Research Institute of Biological Psychiatry (RIBP) of Copenhagen University Hospital and Center for Biological Sequence analysis (CBS) at Denmarks Technical University will work with deCODE on analyzing the data. CNVs associating with SZ, BP and MD in Iceland will be tested in SZ (n=800), BP (n=600) and MD (n=600) and control samples from RIBP using TaqMan probes to measure gene dosage. The confirmation and subsequent functional analysis, including gene expression, will be carried out at deCODE. Scientists from RIBP and CBS will test disease-specific candidate genes, derived from biological networks,  for association to SZ, BP and MD in the Icelandic samples and confirm the findings in the RIBP samples. These methods, reduce the correction factor for false positive findings, as only a small subset of polymorphisms (SNPs and CNVs) will be investigated. This allows identification of susceptibility variants conferring low risk.  Variants, associating with SZ, BP and MD in the follow-up samples, will be studied further by analyzing endophenotypes, i.e. treatment response, severity, etc. in the RIBPsamples. This will implement data stored in the Danish Psychiatric Biobank maintained at RIBP. Scientists from deCODE will work with scientists from RIB
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Beyond Property: Law and Land in the Iberian World (1510-1850)' (1510-1850) under Horizon 2020.

assistant: **Objectives**

The experience of empire decisively shaped the institution of private property in land. From a global perspective, however, the history of this institution is far from straightforward. While European scholarship places the advent of individual property rights in the late 18th century, scholarship on Asia, Africa, and the Americas often attributes the onset of the paradigm of private property to the arrival of Europeans in the 16th century. This discrepancy of almost 300 years is difficult to reconcile. If Europeans had not yet experienced it themselves, how could they introduce the paradigm of proprietary rights across the world during the process of colonization? IberLAND revisits these incongruent historiographical narratives by studying the development of land tenure regimes in the African, American, Asian, and European territories of the Portuguese and Spanish empires. IberLAND takes a unique approach to the study of land tenure by departing from traditional approaches that assume that Europeans ‘invented’ ideas of private property and then ‘transplanted’ them to their overseas possessions. By contrast, IberLAND aims to construct a non-Eurocentric history of the development of land tenure from a global perspective. The research approach cuts across traditional research frontiers not only by integrating diverse regional historiographies but also by combining European and colonial (legal) history. The project will focus on six case studies and build on extensive research in local archives. The research will be strongly interdisciplinary and will gain insights from global, legal, and ethno-history in dialogue with legal theory, postcolonial studies, and decolonial perspectives. By providing a decentered history of land tenure, IberLAND should influence research in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reshaping women's health through the understanding of gynecological fluids. WomEC: Antibody-based IVD test based on 5 novel protein biomarkers quantified in liquid biopsy' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

WomEC is the future of endometrial cancer (EC) diagnosis. It is an in vitro diagnostic test for EC based on 5 novel protein biomarkers that are analyzed in the fluid of a pipelle biopsy, providing a 97% Negative Predictive Value. WomEC has been verified in 4 clinical retrospective studies in 530 patients that resulted in two patents. A verified immunoassay prototype incorporating a proprietary algorithm and antibodies will be completed by January 2023 with clinical validation and commercialization expected for 2024. WomEC is targeted at public and private hospital systems (clinical laboratories) and will benefits woman undergoing the diagnostic process by providing: a faster, more accurate diagnosis, with fewer complications by eliminating the need for invasive tests; and by providing tumor histologic information to improve clinical decision making and optimize surgical treatment leading to a better quality of life, increased life expectancy and reduced cost of care.


**Keywords:** Biomarker,Patient care,Open innovation,Machine learning, statistical data processing, algorithm,protection,immunoassay
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'VALIDATION INDUSTRIELLE D'UNE FILIÈRE DE TRANSFORMATION DU CHANVRE TEXTILE BASÉE SUR LE ROUISSAGE ENZYMATIQUE', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The industrialisation of textile hemp manufacturing is carried out in three stages: separation of anas and stem fibres, retting, processing and cleaning. Specific studies have been carried out in relation to the latter two stages. The aim of this project is an industrial validation of this product line to prove its technical reliability and economic viability. It comprises an examination of interference between the various transformation stages and adaptation of initial transformation machines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Transport EU-Western Balkan Network for Training, Support and Promotion of Cooperation in FP7 research activities' (TRANSBONUS).

assistant: **Innovation**

The overall objective of this project is to improve and promote closer Scientific and Technological (S&T) cooperation opportunities between Europe and the Western Balkan Countries (WBCs) in the area of Surface Transport. The project seeks to establish an EU-Balkan Transport network of researchers and universities among these countries in order to improve and/or enlarge the research capacity of Western Balkan centres of competence in transport in terms of improving their research programs, and scientific and technical human resources. The project aims to fulfil the following specific goals:  •   Identifying the existing capacities and specific needs of surface transport researchers in the Western Balkan countries in terms of FP7 funding opportunities;  •   Training and support in FP7 knowledge and best practices. Enhance the readiness of Balkan transport research community to participate in the European RTD programmes (FP7). •   Setting up a matching tool - “Project Lab” - supporting the creation and preparation of efficient and innovative project proposals;  •   Implementing expert study visits between the WBC partners and EU partners in order to expand the scientific relationships and networking between the two regions; •  Stimulating various partnering schemes and national collaboration between researchers and industry in the surface transport sector in the Balkan region.  Expected activities and tangible results of this project will include, among others: a Roadmap for research capacities and funding opportunities in WBCs transport research, 150 researchers informed and stimulated towards FP7, a database with 100 R&D results, 10 national idea generation events (2 per each WBC + Bulgaria), 50 new project proposal ideas and 5 events in the Balkan countries linking tran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'EXoplanet SpectrosCopy using 0-nOise Photon Energy resolving Detectors' (XSCOOPED) targeting Horizon Europe.

assistant: **Abstract**

The question: ‘are we alone in the universe?’, is a central question in astronomy. It has become even more relevant due to the discovery of exoplanets within the habitable zone around their star. The presence of life could be determined from biomarkers in the spectrum of a planet’s atmosphere. However, an Earth-like planet around a Sun-like star is very faint, after suppressing the starlight. A crucial technology is therefore a noiseless, photon-counting detector, which resolves the energy of each photon. For NASA’s new flagship mission Habitable Worlds Observatory (HWO), detectors have been identified as a large technology-gap with high impact, a gap that should be closed before 2030. Established semiconductor detectors have too high noise, and no energy-resolution.I propose to close this technology gap using energy-resolving microwave kinetic inductance detectors (MKIDs), for visible to near-infrared wavelengths. A single photon generates thousands of excitations in the detector, which gives a direct measure of the photon energy. MKIDs have zero dark current and read noise, and a theoretical intrinsic resolving power of R>150. This enables the detection of biomarkers within each pixel. My group has recently realised three breakthroughs. We have measured R=70 at 402 nm, developed an antireflection coating and a fabrication method that improves yield. I will use these key ingredients to realise a 32 kpixel MKID instrument which meets the HWO specs: R>140 at 1 μm wavelength, an absorption efficiency >90%, and negligible dark counts, with >95% pixel yield.With this proposal, I will enable noiseless exoplanet spectroscopy in space and on ground, and raise the TRL level to ~TRL5 by 2030, in line with the current HWO schedule. A European detector contribution could close a m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Low ecological impact antifouling coatings' in the context of a Fourth Framework call.

assistant: **Objectives**

The objective of this proposal is the study and development of low ecological impact antifouling coatings in marine protection. The draft of the recent European Directive Biocidal Products Directive" - COM (93) 351 Final Syn 465, aims to introduce an unified set of regulations for biocidal products in the European Union that will cover all marine antifouling coatings. Recently, the European Commission has published the criteria to evaluate the products in an annex to the directive (COM (95) 387 Final - COD 465) and they are based on ecological criteria. However, the shipping industry and coating manufacturers are still concerned that these directives could result in a widespread ban on using high performance antifouling coatings. Since at present are not TBT-free alternative products with as good properties as the ones containing TBT, and the shipping industry is demanding them, this project intends to improve the performance of the present TBT-free self-polishing antifouling coatings and to study and/or develop other alternatives. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European Coaching Innovation Standard' (EUCIST) under Sixth Framework.

assistant: **Objectives**

The TEEE-Inn project of the Innovation program has developed since 2002 a method and associated tools for coaching innovative start-ups, and has demonstrated the benefits of using these in a concerted manner between incubators of five European regions. The Technology Transfer Accelerator project of EIF assesses the feasibility of a new type of investment vehicle focused on financing the commercialisation of the results of research. Today, these results are regarded by key finance actors as a breakthrough to be deployed in Europe to facilitate the access of innovative start-ups to early-stage venture capital. EUCIST proposes to disseminate these results to European incubators, in the ICT sector, via the Gate 2 Growth and PAXIS networks. Our aim is to increase significantly the number of new innovative start-ups of the ICT sector, and to reduce their failure rate, in all Member States. Concrete results to be deployed include classical individual support (selection process, commercial and marketing mapping, mentoring, economic intelligence support) and novel small team coaching services: - Specific training for future coaches - BizDev events, which lean to existing major commercial events to organise meetings between entrepreneurs and decision makers - IVCS: the International Venture Capital Summit, where start-ups meet investors. To maximise access to technological clusters, remote markets and investment community, the dissemination will take place into the ICT sector focussing on Software, Telecom and Micro electronics, among candidate regions, not necessarily known for their high potential innovation. To motivate incubators apply for EUCIST, we guarantee a faster access to venture capital for their start-ups. At the end of the project, EIF guidelines for financing innov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Rational Engineering of Synthetic Systems for Propagation of Information via Catalytic Assembly of Copies' to be submitted under Horizon 2020.

assistant: **Abstract**

Copying of information-bearing polymer templates is vital to life. The central dogma of molecular biology describes how a sequence of nucleotides in DNA is copied into a sequence of nucleotides in a newly-assembled RNA polymer, and then into a sequence of amino acids in a protein. These processes involve sophisticated machinery in extant organisms, but even the ribosome is bound by the same physical principles as simpler systems that must have operated in early life. Despite the fundamental importance of copying, and its potential for the engineering of complex molecular systems, we do not understand these basic principles that enable accurate and reliable copies to be made of polymer templates, and cannot build minimal synthetic copying systems.I propose to explore minimal models of copying, leveraging recent advances in the thermodynamics of small, fluctuating systems and the thermodynamics of information processing, to identify these principles. I will translate this insight, via detailed molecular simulation and experimental characterisation of novel reaction motifs, into the construction of minimal synthetic copying systems. I will construct these systems from non-biological synthetic DNA.The project will provide insight into analogous processes in living organisms, and shed light on primitive living systems. It will also lay the groundwork for engineering synthetic systems with key cell-like functionalities, providing a mechanism for the production of complex assemblies that is fundamentally distinct from traditional self-assembly. Theory and simulation will drive the experiments, making rational design of systems possible whilst providing insight into the fundamental thermodynamics of information processing and computation, and the biophysics of novel nucleic aci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of early non-invasive biomarkers and means for the diagnosis and progression monitoring of pre-eclampsia and tailoring putative therapies', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Preeclampsia (PET), de-novo hypertension & proteinuria after mid gestation, affects 5-7% of all pregnancies. Cases may develop life threatening haemolysis-elevated liver enzymes-low platelets (HELLP) or renal failure, cerebral haemorrhages & eclampsia, IUGR, placental abruption & death. We will identify markers for PET risk prediction in the 1st trimester to allow longer time for tailoring putative medications to prevent PET; and assess & characterize plausible links between marker shortage/access, PET & putative medications in in vitro systems to fit putative medications to pre-defined disease-risk women. Candidates for 1st trimester risk prediction of PET (cell free DNA & RNA, serum PP13, ADAM12, PAPP-A) will be verified with new ones using genomics & proteomics. Our blood, urine & fixed placenta tissue banks of pregnant women enable comparative analysis to build integrative, non-invasive Marker Effectiveness Profiles (MEPs) to PET subtypes (early/late onset, mild/severe, HELLP & IUGR). Disease progressions will be detected by continuous marker monitoring. Expertise in trophoblast in-vitro systems (placenta explants & cell lines) and quantitative real time PCR, genomics & proteomics, immunohistochemistry & confocal microscopy will verify markers' roles and identify links to curing effects of putative medications. We will model 'Putative Medication Benefit Arrays' (PMBAs) for PET subtypes matched to MEPs. We will develop non-invasive diagnostic kits for 1st trimester PET prediction based on markers, antibodies, oligos & siRNA and others coupled to the power of Doppler ultrasound. Nested case-control clinical studies will test effectiveness of combined diagnosis & drug tailoring. Trans-European prospective clinical study, combining early diagnosis & randomising putative