RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of a Continue, Intelligent, Autonomous, Real Time Monitoring the Alarming System for Radon Detection in Ground-Water' under Fifth Framework.

assistant: **Concept**

Scientific objectives and approach:The implementation of this project will have far reaching environmental implications for different region. At present no measures have been applied whatsoever to deal with the threat to water quality. The project can therefore be expected to provide a significant improvement on the current situation. The problem of water quality is present throughout the region, as a result of a combination of geological factors. There is a clear need to take immediate measures, to evaluate the scale of the problem, to establish monitoring in relevant sites, and to introduce measures which will lead to an improvement in water quality. It aids the implementation of the first European standardization water policy, which focuses on the maximum allowed quantities of radon authorized in drinking and environmental water. It is clear that there are some technical risks, but the partnership will take all the protections for a successful.A significant part of the project proposal is the development of a continuous real-time monitoring station which is able to detect with a high degree of accuracy even a very low radon concentration in water. The development of this station requires a structured approach by establishing the appropriate design parameters for prototype instrumentation, involving all participants in clearly defining operational requirements, engineering framework, consolidating research, prototype development and laboratory testing of all the key modules. The resulted engineering specification would allow rapid transfer of this technology into manufacture in addition to the determination of operational specifications, thus allowing a complete appraisal of the market potential. The target levels will be selected for the further remedial actions base
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for '200 DEGREE EXTENDED LIFE FUL HT ASIC MEMORY QUARTZ GAUGE' (1994-1998).

assistant: **Innovation**

Geoservices, for many years, has operated down-hole pressure and temperature gauges to measure and record data at reservoir conditions in oil and gas wells.Project target : Demonstration of the use of a full ASIC specially designed electronic chip (Application Specific Integrated Circuit) allows down-hole pressure and temperature gauges to perform at temperatures above 180°C, typically 1000 hours life time at 200°C.As an installation, our new generation of gauges (MQG-X) already integrate a specially designed chip (HT-ASIC) developed by the SINTEF 4 years ago.This ASIC replaces over 20 electronic components and has been implemented on gauges since 1994.The fields results which are excellent, lead us to go one step forward : apply the same electronic integration method to the remaining active integrated circuits and sensible parts of the gauge.The reliability improvement of the gauge at high temperature will open our activity to the rising HP/HT market" (High Pressure/ High Temperature) in the North Sea, Italy, Gulf of Guinea, Arabian Gulf and the Far EastInstallation in the field :The pressure and temperature gauges are run down-hole in oil and gas wells, with a metallic wire (slick line) typically 0.092 "OD or clamped on a special drill collars (gauge carriers) when used in a DST (Drill Stem test). The depth can be over 5000 m and the temperature can reach 200°C. The gauges are battery powered and typical dimensions are 1"1/4 OD and 1m long.Working principle :The gauge consists of : - 1 pressure sensor which converts the well down-hole pressure and temperature to electrical signals.- 1 micro-controller which converts these signals to digital data- 1 non volatile memory components where the data are stored.The memory is download on surface through a computer which conve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Metaheuristics network' under Fifth Framework.

assistant: **Concept**

The Metaheuristics Network will be concerned with the study of a wide variety of metaheuristics an NP-hard problems. The young researchers involved in the network will be exposed to a variety of techniques, as well as to the challenge of applying them to many different situation and problems, both in academic and industrial settings. The research subject is therefore very well suited for training purposes because there are many different techniques involved which require evaluation and experimentation by teams of people with different background and experience and working co-operatively to the solution of a common problem. The main training goals of the network are:(i) to let young researchers learn about all the tested techniques as well as about a number of important optimization problems,(ii) to let them learn how to design experiments in a rigorous way, and(iii) to develop their project management skills by means of participation in a strictly co-ordinated team activity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Surface Characterisation and Modelling for Self-Cleaning Function'.

assistant: **Innovation**

Human beings have long tried to learn from and mimic nature. A good example is the successful mimicry, by means of nanotechnology, of the ‘lotus leaf effect’ in many applications requiring self-cleaning from skyscrapers, machine tools’ work surfaces and even to clothes. Surface micro and nano-topography (finish, texture) obviously affects the performance of many engineered and natural systems. The proposed research is aimed at establishing functionally useful correlations between surface micro-geometry and mechanical and tribological properties. It specifically focuses to elucidate the effect of surface features on the local adhesion, friction, hardness and elastic modulus in terms of anti-adhesion and anti-contamination performances.The proposal will bring the joined expertise in both surface measurement and characterisation by Warwick Group and surface modelling by Dr Tian to achieve above ultimate objectives. We will first study the functional surfaces exhibited by engineered and natural systems for their anti-adhesion and anti-contamination performances. Numerical simulation and modelling will be carried out to generate such surfaces with controlled surface parameters, in order to study the effect of surface topography on the contact angle, adhesion and friction and nano-hardness, and the relationships between. Eventually, this will pave a way for scientists and engineers to design an ideal surface structure or topography for a specific function at a low cost.The research will provide benefits for the sponsor by publishing peer reviewed papers and establishing key enabling methodologies for characterisation and generation of such functional surfaces. The capability of the micro/nano surface measurement and metrology is of high benefit to both UK and European enginee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Robotic and Electrical Stimulation Platform for Integral Neuromuscular Enhancement' to be submitted under Horizon Europe.

assistant: **Abstract**

RE-SPINE develops a real-time neuro-robotic platform for lower limb rehabilitation. Motor recovery following neuromuscular injuries is often sub-optimal. A key barrier hampering progress is that current neurorehabilitation robots interact with the human with limited knowledge of their effect on critical neuromuscular targets.RE-SPINE addresses this challenge by proposing a platform that integrates a stationary robotic ankle exoskeleton with a non-invasive spinal cord electrical stimulation system. This platform generates electrical and mechanical stimuli non-invasively, which are directed to spinal motor neurons and innervated muscle fibers, with precision not considered before. RE-SPINE combines non-invasive biosignal recording and numerical modelling to decode the cellular activity of spinal motor neurons, with the resulting mechanical forces generated by innervated muscle fibers. In this way, residual spinal motor neuron activity is translated into biomechanical force, which is subsequently used to enable volitional and continuous control of a stationary robotic ankle exoskeleton across a wide range of joint rotations, which could not be otherwise achieved without neuro-robotic support. Concurrently, decoded spinal motor neuron activity is used to command spinal cord electrical stimulation patterns that modulate spinal excitability and neuronal synchronization, ultimately for enhancing volitional control of the own leg. Over time, the integrated effects of neuro-controlled electrical and mechanical stimulation promote positive neuro-plastic changes, which are required for gaining an integral motor recovery after injury, with potentials for disrupting current robotic systems for rehabilitation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cognitive and Cerebrovascular Effects Induced by Low Dose Ionising Radiation' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The major elements of scientific uncertainty in the context of radiation protection policy and of risk assessment for cerebrovascular diseases, set the following key topics (1) the direct assessment of health effects through epidemiological studies of groups exposed to low doses, (2) doses-response and biological effects from different types of radiation and (3) the biological processes in cells and tissues mediating the cerebrovascular effects of low-dose radiation. These 3 topics have been identified as priorities by the HLEG, the MELODI Strategic Agenda and ARCH (Agenda for Research on Chernobyl Health), and will be covered in the CEREBRAD (Cognitive and Cerebrovascular Effects Induced by Low Dose Ionising Radiation) project. CEREBRAD will address the problem of cerebrovascular effects  in humans: in individuals that were exposed in utero, in cohorts of adults from the Chernobyl liquidators, and in children receiving low doses to the brain during cancer radiotherapy. We will study cognitive effects in animal models exposed to radiation at different stages of brain development, with special emphasis on early postnatal exposures, and will examine the initial and late effects induced in brain by irradiation at the cellular and molecular levels.The main concern of CEREBRAD is to identify the potential risk of doses below 100 mGy delivered to a young child. To inform on risk estimates of the effect from internal and external exposures, as well as synergistic effect with other environmental pollutants, all these different conditions will be evaluated. The consortium is an interdisciplinary team of radiobiologists, epidemiologists, experts in neurodegenerative diseases, genomics, proteomics and bioinformatics, paediatricians and dosimetrists. Special attention will be paid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel approaches for the control of fungal disease' (1998-2002).

assistant: **Innovation**

The rapid rise in fungal infections represents an important socio-economic challenge for the Esther development of more effective ant fungal therapies independent upon an increased understanding of fungal virulence. This Consortium will focus on Candid albicans,the major fungal pathogen in humans. We will exploit the latest molecular and genomic technologies to generate the most comprehensive and integrated database on Candid virulence to date.Candida gene arrays will be used to monitor global responses to developmental changes, environmental stimuli and contact with host tissues. This will be combined with a novel screen to identify new host-fungus interactions as well as the molecular dissection of key fungal virulence factors: yeast-hyphen morph genesis, cell wall, phenotypic switching and secreted hydrolases.Our findings will be used to improve ant fungal therapies, and will be made public via our new relational Candid genomic database.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Blocking the prion-like disease propagation in Parkinson’s disease and related disorders – model development and identification of cell-autonomous and cell non-autonomous factors.' under Horizon 2020.

assistant: **Concept**

A prion-like behavior of α-synuclein (AS) protein has been hypothesized in the pathogenesis of Parkinson disease (PD). According to this hypothesis, pathogenic forms “seeds” of AS propagate from periphery into the neurons of central nervous system (CNS), where they recruit endogenous AS in the first receiving neurons, exit the cell and enter connected neurons. The ongoing AS aggregation and cell-cell propagation is considered to induce oxidative stress, neuronal dysfunction and neuronal loss in CNS. Therefore, blocking the neuronal propagation of AS will prevent AS neurotoxicity and neurodegeneration. I propose to develop and validate a novel in vivo model of prion-like AS propagation, in which I will selectively modify the genetic makeup of first receiving neurons, and use this model for mechanistic investigations. I will use a transgenic M83 mouse model overexpressing mutant A53T human AS in which prion-like spreading is initiated by injecting preformed AS aggregates into the hindlimb musculus femoris. These AS aggregates are taken up by sensory and/or motor nerve endings in the muscle, are retrogradely transported through the sciatic nerve into spinal cord, and rostrally into the brainstem and higher brain areas over time. I will refine this model by transducing the sciatic nerve endings with intramuscular delivery of rAAV viral vectors- containing novel CRISPR/Cas9 genome editing tools targeting genes of interest- to prevent in vivo prion-like AS spreading and/or toxicity. As proof of concept, I will silence AS in the receiving neurons to demonstrate this slows the disease development in the model. Once validated, I will use the model for hypothesis-driven mechanistic investigations of candidate genes, which initially include: 1) ubiquitin specific peptidase 19 (USP
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Artificial Intelligence for Air Quality' under Horizon 2020.

assistant: **Concept**

The IntelliAQ project will develop novel approaches for the analysis and synthesis of global air quality data based on deep neural networks. The foundation of this project is the world’s largest collection of surface air quality measurements, which was recently assembled by the principal investigator and plays a pivotal role in the ongoing first comprehensive Tropospheric Ozone Assessment Report (TOAR). This database will be complemented with data from the world’s leading effort to collect global air pollutant measurements in near realtime and combined with high-resolution geodata, weather information, and satellite retrievals of atmospheric composition in order to characterize individual measurement locations and regional air pollution patterns. State-of-the-art deep learning methods will be applied to this unprecedented dataset in order to 1) fill observation gaps in space and time, 2) provide short-term forecasts of air quality, and 3) assess the quality of air pollutant information from diverse measurements. The combination of diverse data sources is unique, and the project will be the first to apply the full potential of deep neural networks on global air quality data. The achievement of the three IntelliAQ objectives will shift the analysis of global air pollutant observations to a new level and provide a basis for the future development of innovative air quality services with robust scientific underpinning. Due to the heterogeneity of the multivariate data, lack of structure, and generally unknown uncertainty of the input data, the project also poses challenges for existing deep learning methods, and will thus lead to new developments in this field. Direct outcomes of the project will be a substantial improvement of global air quality information including method
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Anionic redox processes:  A transformational approach for advanced energy materials' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Redox chemistry provides the fundamental basis for numerous energy-related electrochemical devices, among which Li-ion batteries (LIB) have become the premier energy storage technology for portable electronics and vehicle electrification. Throughout its history, LIB technology has relied on cationic redox reactions as the sole source of energy storage capacity.  This is no longer true. In 2013 we demonstrated that Li-driven reversible formation of (O2)n peroxo-groups in new layered oxides led to extraordinary increases in energy storage capacity. This finding, which is receiving worldwide attention, represents a transformational approach for creating advanced energy materials for not only energy storage, but also water splitting applications as both involve peroxo species. However, as is often the case with new discoveries, the fundamental science at work needs to be rationalized and understood. Specifically, what are the mechanisms for ion and electron transport in these Li-driven anionic redox reactions?  To address these seminal questions and to widen the spectrum of materials (transition metal and anion) showing anionic redox chemistry, we propose a comprehensive research program that combines experimental and computational methods. The experimental methods include structural and electrochemical analyses (both ex-situ and in-situ), and computational modeling will be based on first-principles DFT for identifying the fundamental processes that enable anionic redox activity. The knowledge gained from these studies, in combination with our expertise in inorganic synthesis, will enable us to design a new generation of Li-ion battery materials that exhibit substantial increases (20 -30%) in energy storage capacity, with additional impacts on the development of Na-ion bat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'INTRODUCTION OF A RANGE OF L-CYSTEINE DERIVATIVES AS NUTRITIONAL ADDITIVES IN PET FOOD, TO REDUCE OBESITY AND LENGTHEN ANIMAL LIFE' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Veterinary research shows that up to 45% of cats and dogs suffer health disorders, with oxidative effects from nutritionalimbalances as a significant contributing factor. Of the approximately 270 million pets in the EU, 60% have commercial petfood exclusively as their source of nutrition and therefore depend on a complete and balanced product for health andwellbeing.The PetLife project is based on a promising market and growth opportunity deriving from our current L-Cysteine derivativeproduct line for use in plant nutrition. This latent cysteine is released into the plant gradually, providing its organism withseveral essential health benefits that extend to animals as well. AXEB is set to be the first in Europe and globally to validateand introduce L-cysteine derivatives as nutritional additives for animals, to solve the problem of providing cysteine withoutcausing nutritional imbalances and weight gain. The health benefits to be proved in phase 2 validation will convince petowners and feed manufacturers of the worth of these new added-value formulations.Our objective is to take advantage of our know-how in order to broaden the use of this innovative compound as an animalnutrient and access the EU pet food industry and European pet owners who spend up to €21,000 on each pet over itslifetime, and €55 per pet every year on veterinary care.When scaled up to industrial production, the proposed PetLife L-Cysteine derivatives will be commercialized with a targetprice 25% cheaper than current pet food additives, and provide more long-ranging health benefits to reduce end userveterinary expenses.Although we already possess the knowledge in biotechnology processes for molecule synthesis, we require assistance toenter the pet food market due to the rigorous regulatory approval pr