RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Open Access Infrastructure for Research in Europe 2020' (OpenAIRE2020) under Horizon 2020.

assistant: **Objectives**

OpenAIRE2020 represents a pivotal phase in the long-term effort to implement and strengthen the impact of the Open Access (OA) policies of the European Commission (EC), building on the achievements of the OpenAIRE projects. OpenAIRE2020 will expand and leverage its focus from (1) the agents and resources of scholarly communication to workflows and processes, (2) from publications to data, software, and other research outputs, and the links between them, and (3) strengthen the relationship of European OA infrastructures with other regions of the world, in particular Latin America and the U.S. Through these efforts OpenAIRE2020 will truly support and accelerate Open Science and Scholarship, of which Open Access is of fundamental importance.OpenAIRE2020 continues and extends OpenAIRE’s scholarly communication infrastructure to manage and monitor the outcomes of EC-funded research. It combines its substantial networking capacities and technical capabilities to deliver a robust infrastructure offering support for the Open Access policies in Horizon 2020, via a range of pan-European outreach activities and a suite of services for key stakeholders. It provides researcher support and services for the Open Data Pilot and investigates its legal ramifications. The project offers to national funders the ability to implement OpenAIRE services to monitor research output, whilst new impact measures for research are investigated. OpenAIRE2020 engages with innovative publishing and data initiatives via studies and pilots. By liaising with global infrastructures, it ensures international interoperability of repositories and their valuable OA contents.To ensure sustainability and long-term health for the overall OpenAIRE infrastructure, the proposed OpenAIRE2020 project will establish its
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Automated technology for the loading and positioning of co-moulded components.' in the context of a Fifth Framework call.

assistant: **Objectives**

Plastic components containing metallic parts are widespread due to their versatility and performance. Many sectors make use of them and the demand will grow considerably. The production techniques are not optimised and are faced with the problem of placing the metallic parts in the plastic moulds, which at present is done manually and causes a huge increase in the time to produce components, a reduction of throughput and increased costs. This project will develop automated ways to load metallic parts. This will be done by combining direct expertise in co-moulding, control of industrial processes, precision mechanics and chemistry. An automated system to load metallic parts on moulds will cut by a factor of 2-3 the production cycle with a proportional gain in terms of throughput and cost-efficiency. The project will generate markets of millions of Euro, will improve the technology and the work environment of many industries, and will create employment for technical staff in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Dna and chromosomes'.

assistant: **Concept**

The objective of this proposal is to organise a high-level multidisciplinary Euro Summer School on DNA and Chromosomes. A full understanding of the structure and functions of DNA and chromosomes requires a multidisciplinary approach. This field is attracting an increasing number of researchers coming from various disciplines. Computer scientists for instance build DNA computers; mathematicians study DNA topology, and polymer physicists take advantage the exceptional polymeric properties of DNA. On the other hand, there is a growing understanding among molecular biologists that biology will in the future benefit of the knowledge accumulated in physics and in physical chemistry. Finally, fundamental questions in molecular biology of the nucleus lead on to physical questions. This multidisciplinary approach, which has led to important results in the past, is expected to have a growing impact in the next decade. Indeed, recent years have witnessed a burst of novel experimental tools to probe structure and dynamics of DNA molecule in vitro and in vivo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New proxies to quantify continental climate development during the Pliocene' (PLIOPROX).

assistant: **Innovation**

Atmospheric CO2 concentrations have risen rapidly since pre-industrial times and our current climate is not yet in equilibrium with this; it will change. To obtain insight in the type and magnitude of this change and to validate climate models used to project these changes, we need to look back at past climates. The most recent time in Earth history with CO2 levels that were similar to today is the Pliocene. The Pliocene thus provides a unique window into a world that exhibited many of the climate characteristics that we might experience. These are documented by proxies locked into sedimentary archives, especially marine sediments. It remains a challenge for palaeoclimatologists, however, to quantify past terrestrial temperatures. I have recently developed a novel proxy for quantitative annual mean air temperature reconstruction, which is based on the distribution of membrane lipids synthesised by soil bacteria. Upon soil erosion these molecules are transported to the marine realm where they become part of the marine sedimentary archive.The PlioProx project aims at a quantitative reconstruction of continental temperatures and latitudinal temperature gradients for the Pliocene. This will be achieved by applying this new palaeothermometer to high resolution marine sediment records near river outflows to generate river-basin integrated records of continental air temperature. This approach also allows for a direct comparison to reconstructed sea surface temperatures. Using globally distributed sediment records, latitudinal temperature gradients will be constructed which will be compared to moisture transport and rainout, reconstructed using stable hydrogen isotopes from plant wax lipids. Results will provide vital new insights in climate evolution on land under elevated atm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Intelligent Information System Supporting Observation, Searching and Detection for Security of Citizens in Urban Environment' (INDECT), addressing dissemination and exploitation.

assistant: **Impact**

The main objectives of the INDECT project are: • to develop a platform for: the registration and exchange of operational data, acquisition of multimedia content, intelligent processing of all information and automatic detection of threats and recognition of abnormal behaviour or violence, • to develop the prototype of an integrated, network-centric system supporting the operational activities of police officers, providing techniques and tools for observation of various mobile objects, • to develop a new type of search engine combining direct search of images and video based on watermarked contents, and the storage of metadata in the form of digital watermarks, • to develop a set of techniques supporting surveillance of internet resources, analysis of the acquired information, and detection of criminal activities and threats. The main expected results of the INDECT project are: • piloting installation of the monitoring and surveillance system in various points of city agglomeration and demonstration of the prototype of the system with 15 node stations, • implementation of a distributed computer system that is capable of acquisition, storage and effective sharing on demand of the data as well as intelligent processing, • construction of a family of prototypes of devices used for mobile object tracking, • construction of a search engine for fast detection of persons and documents based on watermarking technology and utilising comprehensive research on watermarking technology used for semantic search, • construction of agents assigned to continuous and automatic monitoring of public resources such as: web sites, discussion forums, usenet groups, file servers, p2p networks as well as individual computer systems, • building an Internet based intelligence gathering system, bot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Stabilization of Protein Protein Interactions; transforming molecular glue discovery from art into science' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Intrinsically Disordered Proteins (IDPs) represent one of drug discovery’s major challenges. Due to their high degree of conformational freedom, IDPs have no defined pockets for binding small molecules. Molecular glues that can strengthen protein-protein interactions (PPIs) are a revolutionary technology for drug discovery. The hub protein 14-3-3 regulates many IDPs via phosphorylation-dependent PPIs. Stabilization of 14-3-3 PPIs with small molecular glues provides a unique entry point to render IDPs druggable and mitigate the aberrant behaviour of malfunctioning IDPs, for example in neurodegenerative diseases.While inhibition of PPIs by small molecules has expanded the proteome suitable for therapeutic intervention, the opposite chemical-biology strategy of PPI stabilization by small molecular glues is, despite a recent surge of interest, remarkably underexplored. The lack of mechanistically understanding PPI stabilization impedes systematically identifying molecular glues and limits progress to drug IDPs. Based on compelling preliminary data, I propose here that mechanistic understanding of 14-3-3 PPI stabilization will play a crucial role in the discovery of molecular glues for IDPs and transform molecular glue drug discovery from art into science.We will tackle this central question by pursuing two key objectives: Objective 1 – Mechanistically understand PPI stabilization between the 14-3-3 scaffold protein and IDPs. This will address the underlying thermodynamic and kinetic processes, conformational selection, multivalency, cooperativity and selectivity; Objective 2 –Drugging the undruggable -biomolecular condensates and IDPs- via PPI stabilization approaches. The potential for PPI stabilization in the dense environments of biomolecular condensates will be uncovere
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Prevalence of various genetic and epigenetic changes in genes associated with the anti-cancer drug 5-FU metabolism in patients with severe toxicity, healthy donors and various Israeli populations'.

assistant: **Innovation**

5-Fluorouracil (5-FU) has been one of the most commonly used drugs in the treatment of various types of cancer (in particular, colorectal and breast) for the past fifty years. 5-FU is a drug for which genetic and epigenetic variation in the drug-metabolizing enzyme (dihydropyrimidine dehydrogenase [DPD]) and the drug target enzyme (thymidyalate synthase [TS]) can influence both toxicity and response to treatment. Through a comprehensive investigation and screening of various genetic (SNPs, deletions, insertions and duplications) and epigenetic (methylation in the promoter region) variations in the six major genes (DPYD, DHP, BUP, TP, OPRT and TS) encoding 5-FU metabolizing enzymes, we intend to identify the spectrum of molecular alterations associated with a patient’s response to the drug. We will then measure the frequency of known and newly observed mutations in patients with adverse side effects, healthy volunteers and various Israeli populations. The following step will be to establish a set of mutations that is likely to more fully elucidate the causes that impact the toxicity and efficacy of 5-FU. Finally, we will translate our research findings into a genetic testing tool for use prior to cancer treatment, thus integrating Pharmacogenetics into health care practice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Progress novel assets (one FIH start) for non-tubercular mycobacteria that may act synergistically with bedaquiline'.

assistant: **Objectives**

Non-tuberculous mycobacteria, such as Mycobacterium avium complex (MAC) and Mycobacterium abscessus, cause lung diseases resembling TB, mainly in immune-compromised patients or patients suffering from other lung diseases (e.g. cystic fibrosis). The incidence and prevalence of lung diseases caused by NTM are increasing worldwide. Importantly, in the US and Japan, as well as in other areas of the world where TB has declined, NTM disease is already at least three times more prevalent than TB. Treatment of NTM diseases relies on antibiotic combinations, however the drugs active against NTM are rather few and mainly different than those active against TB. These NTM treatments for the most common species (MAC and M. abscessus) are much less active than the current anti-TB regimen is for TB treatment. It is often necessary to administer antibiotic combinations for at least 12-24 months. The long and complex drug regimen that is currently recommended as a treatment against NTM-caused diseases carries the risk of inducing resistance in NTM. Several studies have already shown the existence and emergence of multidrug resistant NTM. The overall objective of RESPIRI-NTM is to find new drug candidates as potential components of a new, more efficient combination drug regimen against NTM that is less prone to resistance and allows shortening of treatment duration for NTM and multidrug-resistant NTM. Such a drug combination will synergistically target the energy metabolism of NTM or complementary targets. To achieve this, we will advance recently discovered inhibitors of the mycobacterial respiratory pathway. In addition, we will perform a novel, phenotypic screen in order to identify novel targets in NTM. We will also target host-factors that are essential for the intracellular surviva
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nanoscopic and Hierachical Materials via Living Crystallization-Driven Self-Assembly' under Horizon 2020.

assistant: **Concept**

A key synthetic challenge of widespread interest in chemical science involves the creation of well-defined 2D functional materials that exist on a length-scale of nanometers to microns. In this ambitious 5 year proposal we aim to tackle this issue by exploiting the unique opportunities made possible by recent developments with the living crystallization-driven self-assembly (CDSA) platform. Using this solution processing approach, amphiphilic block copolymers (BCPs) with crystallizable blocks, related amphiphiles, and polymers with charged end groups will be used to predictably construct monodisperse samples of tailored, functional soft matter-based 2D nanostructures with controlled shape, size, and spatially-defined chemistries. Many of the resulting nanostructures will also offer unprecedented opportunities as precursors to materials with hierarchical structures through further solution-based “bottom-up” assembly methods. In addition to fundamental studies, the proposed work also aims to make important impact in the cutting-edge fields of liquid crystals, interface stabilization, catalysis, supramolecular polymers, and hierarchical materials.


**Keywords:** Block Copolymer Self-Assembly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'First fast and automated (<5 min) AI-based inspection to increase operational safety of large critical infrastructure, e.g., bridges, dams, and oil & gas platforms and refineries' (Twinspect), addressing dissemination and exploitation.

assistant: **Impact**

The global inspection, repair, and maintenance market (TAM) is valued at €42.2B. Demand is driven by increasing urbanisation. In Europe, most of the infrastructure is now reaching its 50-100 years lifespan as it was built in the 50s and 60s following the Marshall plan. The drone inspection and monitoring market (SAM) is growing rapidly and is currently valued at €11.1B. Drone inspections enable OPEX & CAPEX savings and keep inspectors safe on the ground. This is driving the demand for data management solutions (one bridge inspection generates >30GB of data), and provides a unique opportunity for intelligence service providers, like us, to enter the market with innovative AI-based solutions that simplify and automate infrastructure inspection. Twinspect is the first photogrammetry solution to enable the inspection of photorealistic 3D models of the infrastructure directly, rather than having to inspect and annotate (often multiple times) defects in large (>2k) photo libraries manually.


**Keywords:** Deep Learning,Computer Vision,3D models,Digital Twin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Application of high-intensity ultrasound for removing occluded bubbles and for superficial homogeneisation in quick-drying industrial coating'.

assistant: **Concept**

High-intensity ultrasound could be a useful and clean way to achieve uniform coating of materials and to improve impregnation when incorporated in coating application and drying machinery. Ultrasonic radiation applied to varnishing or painting processes may favour the quick removal of the air and, at the same time, the penetration of the liquid in the wood. The application of the ultrasonic energy has to be based on the right combination of several effects that can be produced by high-intensity ultrasonic waves, such as: bubble breaking, degassing, dewatering, capillary diffusion, radiation pressure, etc. In addition, the practical implementation of this potential technique will require the development of special air-borne ultrasonic radiators capable of generating the required intensities. The objective of this project is the study, development and implementation of a new technology based on the application of air-borne ultrasonic radiation in high-speed quick-drying industrial varnishing and painting processes in order to improve wood surface finishing without using additives.