RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Development and Commercialisation of a complete compostable film packaging system'.

assistant: **Concept**

In the light of the recently published ‘A European Strategy for Plastics in a Circular Economy’ document, all stakeholders involved in the life cycle of plastic packaging are striving towards achieving a solution which could curb plastic pollution and its adverse impact on our lives and the environment. Consumers and retailers demand a packaging film which can be 100% recycled or can be completely biologically decomposed. Compostable plastics have the ability to break down, safely and relatively quickly, by biological means, into the raw materials of nature and disappear into the environment (soil). There is a need of a totally compostable wrapping packaging solution (film, label and tray) along with an easy-to-use (and maintain) cost effective packaging machines.  2.  3. In a response to this market need, the project consortium led by Fabbri Group is developing a platform technology ‘Nature Fresh’ which is a complete compostable film packaging solution targeted specifically at the fresh food packaging markets (meat, fish, dairy, fruit and vegetables). Nature Fresh delivers retailers. food processors, and the common public direct environmental benefits and addresses a current opportunity to reduce the use of plastic. At the same time the product will assist in meeting sustainability initiatives.   Through this 30 months FTI project, the consortium aims to carry out activities such as commercial scale manufacturing of the compostable films, design and development of the automatic wrapping machines, design and development compostable label, gain regulatory approvals and conduct end-user trials to gain market acceptance and a swift market entry by Q2- 2022.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Short wave reflection from coastal structures - scouring processes and sediment transport', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content Coastal Structures, like groins and mound breakwaters are buil to protect an area from the wind wave action. Generally speaking, they dissipate wave energy inducing wave breaking. However, depending on the type of reflective structure and of the incinent wave characteristics, part of the energy is returned to the sea under the Reflection Process. The interaction between the incident and the reflected wave trains develope complex wave patterns of diamond shape, enhancing the wave amplitude in certain points while reducing and others. It is well known m the Engineering Practice, that coastal structures built on sandy coasts, may suffer scour erosion and enhance the sediment transport. Furthermore, toe erosion may induce the sliding failure modes of the bottom berm, of the main layer and of the whole breakwater. The location and extension where scouring occurs, is still undetermined and there are not well established engineering rules to face this problem. This proposal is related to the problem of sediment movement m front and around reflective structures. The final goal of the research is to provide sediment patterns and simple prevention techniques depending on the reflectivity of the structure and on the wave characteristics, including wave spectrum and incidence angle. The Research Project includes the following main aims as the basis for the establishment of engineering rules to prevent scouring in front I and around coastal structures: al. Analytical model of the wave scattering from a semi-infinite mound breakwaters on an horizontal bottom. a2. Radiation stress distribution a3. Mean flows inside and outside the breakwater. a3. Sediment Movement. a4. Preventive actions a5. Submerged structures and bars Training content (objective, ben
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sustainable improvement in safety of tailings facilities' under Fifth Framework.

assistant: **Concept**

Tailings are fine-grained wastes of the mining industry, output as slurries, due to mixing with water during mineral processing. Deposits of these residues in ponds or lagoons, usually confined by man-made dams, can present a serious threat. Especially where there is improper handling and management. Recent accidents at tailings facilities, such as the Baia Mare (Romania) and the Aznalcollar (Spain) disasters, resulted in major hazards to the environment and human life. The project intends to develop and apply methods of parameter evaluation and measurement for the detection, assessment and improvement of the safety state of tailings dams and ponds. Aspects of probabilistic stability analysis, water management involving paste technology, non-destructive testing and monitoring methods, and intervention and practical remediation options will be considered. The results will be incorporated in a systematic risk reduction framework.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Brain-Specific, Modular and Active RNA Therapeutics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The overall objective of B-SMART is: 1. to design modular nanoparticles, 2. to manufacture them via a quality-by-design protocol, 3. to achieve delivery of therapeutic RNAs to the brain and treat neurodegenerative diseases. I.To design modular nanoparticles consisting of oan active RNA payloadoestablished (lipid-based), emerging (trigger-responsive polymer-based) or exploratory (extracellular vesicle-based) nanoparticlesoa targeting ligand  consisting of the variable domain of heavy chain only antibodies (also known as VHHs or nanobodies), which are coupled to the carrier platformII.To manufacture the modular nanoparticles using a microfluidic assembly system that will ensure quality-by-design: uniform nanoparticles across research sites and excellent control over the physico-chemical parameters.  III.To test pre-clinical activity of formulations with promising in vitro activity with good cell/blood compatibility and to select the best RNA-formulation for clinical translation to treat neurodegenerative diseases.Pre-clinical efficacy is tested aftero    local injection o    nasal administrationo    systemic administrationThe neurodegenerative diseases carry a high burden for patients since they are without exception progressive. But they also carry a substantial socio-economic burden with estimated costs of 130 billion euro. per year (2008).IV.The technical work in B-SMART will be supported by project management. It ensures that the project is coordinated in a clear, unambiguous and mutually acceptable manner and that the project achieves its objectives, within the given financial and time constraints.in B-SMART we expect to arrive at a scale-able nanoparticle formulation with uniform characteristics that shows strong pre-clinical evidence of therapeutic efficacy and is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The ecological significance of telomere dynamics: environments, individuals and inheritance' (ECOTELO) targeting Seventh Framework.

assistant: **Abstract**

The current pace of change is such that many organisms face ever more rapid and severe fluctuations in their physical and biotic environments. A major challenge for ecologists and evolutionary biologists is in understanding how this will influence individuals, populations and ecosystems, and over what time scale such effects will occur. There is now great interest in so called 'maternal effects', which can generate rapid phenotypic responses, with both positive and negative fitness consequences in an ecological timeframe. In this project, I propose to examine a hitherto unconsidered route whereby the state of the mother alters the DNA that her offspring inherit, with profound effects on offspring reproductive performance and potential lifespan. This route is the effect of maternal state on telomeres, the DNA sequences that cap chromosomes ends; changes in the length and loss rate of telomeres could affect the longevity and reproductive output of individuals, their offspring and even grand-offspring. We still know very little about what telomere loss measurable at the cellular level actually means for organismal level performance, how it is influenced by environmental factors and intergenerational maternal effects, and how telomere dynamics relate to Darwinian fitness parameters.  We lack experimental studies that track telomere loss within individuals subjected to varying environmental circumstances and relate this to organismal level outcomes for parents and offspring. I plan to address this gap in our understanding in a novel and innovative experimental programme that tests the idea that the effects of environmental stressors on senescence rates and lifespan are linked to accelerated telomere loss and that, through this route, can affect more than one generation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Narratives, Myths, and Religious Rituals in Football under the Franco Regime and the Shifting Powers in Argentina (1939-1976)'.

assistant: **Innovation**

The FAITHBALL project explores the intersection of football, politics, and culture in Spain and Argentina from 1939 to 1976, focusing on the Franco and Perón regimes. Football, often seen merely as a sport, was harnessed as a tool of propaganda and diplomacy during this period, shaping national identities and international relations. The project aims to bridge the gap in existing research by providing a comparative analysis of how football was used to reinforce political narratives and enhance diplomatic ties between these countries. In addition to examining legislative and media portrayals, major football events, and their impact on national and regional identities, the FAITHBALL project will delve into the social and cultural dimensions of football through the study of rituals, myths, and narratives. Football in both Spain and Argentina was not just a game but a powerful cultural phenomenon, woven into the social fabric through specific rituals and myths that reflected and reinforced the political and cultural climate of the time. By analyzing how football rituals and collective myths were constructed and propagated, the project will uncover how these elements contributed to the shaping of national and regional identities and influenced societal values and collective memory. Through an interdisciplinary approach, combining historical, sociological, and digital humanities perspectives, it will develop a comprehensive framework to understand football's role in political and cultural dynamics. Throughout the project, the following deliverables will be produced: a monograph, several academic articles, a podcast, an open-access database and an interactive digital map designed to facilitate further research and provide new insights into the role of football in shaping natio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mapping quantitative trait loci for water use efficiency in potato (Solanum tuberosum)' (ELITE), addressing dissemination and exploitation.

assistant: **Impact**

A great challenge for  potato production in the coming decades is to maintain or increase food production with a reduced availability of water. This  can be achieved  by understanding mechanisms for adaptation to water stress conditions and exploiting the existing variation in the crop and wild relatives.  The specific objectives of this project include (a) to understand physiological mechanisms of adaptation to water stress and drought tolerance, and to improve water use (b) to assess the impact of water stress, rainfall variability and climatic change on yield, and other physiological parameters and develop a knowledge base about crop water productivity under different water stress and management practices and identify Quantitative Trait Loci (QTL) (c) to capture and identify naturally occurring variation for adaption to water stress conditions and identify genetic regions of interest associated with water stress tolerance and yield under stress by using trait gene correlations aiming at associations due to several years of recombination in potato germplasm (d) to prepare crop models from G×E information available on yield and physiological parameters from multi-year trials which will help predict better performing genotypes under prevailing climatic conditions and (e) to link the phenotypic parameters to candidate genes by using information from model plant studies and cereal crops.These objective will be achieved by developing knowledge and tools for breeding for Water Use Efficiency (WUE) which involves: physiological parameter measurements, eco-physiological approaches and agronomical practices in crop production and development of molecular marker resources to map QTL’s for environmentally sustainable traits.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Area-specific transcriptional dynamics and plasticity of neocortical neurons' under Horizon 2020.

assistant: **Concept**

Cellular diversity in the nervous system determines the variety of circuits that set the framework for brain function. These different types of neurons emerge during pre- and post-natal development through the regulation of gene networks by two archetypical processes: cell-intrinsic processes, which are independent of environmental conditions, and cell-extrinsic processes, which are triggered by environmental signals. A continuum of interactions between intrinsic and extrinsic processes underlie cellular states. However, their respective contribution to neuronal identity has been difficult to untangle because neurons are highly interconnected and heterogeneous cell-types with distinct and dynamic sensitivities to environmental signals. Here, using the mouse neocortex as a model system, I will investigate how cell-intrinsic and cell-extrinsic processes interact to define neuronal identities using Patch-seq assessment of neuronal molecular identity following transplantation across cortical areas. Neuronal “plasticity” will be assessed by transplantation, which corresponds to the artificial altering of the environmental factors. Data comparison between transplanted neurons and controls will identify the candidate of “core genes” which regulate the environment-dependent plasticity of neuronal differentiation. Finally, I will manipulate these candidate genes and analyze their effect on final neuronal identity to validate their causal relationship. Altogether, this study will contribute to revealing the plasticity of neuronal identity across cortical areas and to addressing environment-dependent molecular mechanisms controlling the plasticity. In the long term, this may contribute to a better understanding of neurodevelopmental and psychiatric disorders, in which cell-intrins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Statistical Methods for Accurate Quantification of MicroRNA Expression via Small RNA Sequencing' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

MicroRNAs (miRNAs) are a class of highly conserved small non-coding RNAs that regulate the expression of most protein coding genes. MiRNAs have been extensively studied, not only to understand their molecular function but also due to their potential as therapeutic and diagnostic tools. Most current studies rely on small RNA sequencing (sRNA-seq), recently extended to single cells, because it allows to measure all miRNAs present in a sample even at low input amounts. However, state-of-the-art statistical analysis of sRNA-seq data is still performed using standard mRNA-seq software. This is inappropriate because miRNA counts violate several assumptions of these methods. In extreme cases, upregulated miRNAs will falsely seem down-/upregulated because of technical effects. Technical bias is even more severe in low input applications, e.g., single-cell, so decreasing the RNA input lowers quantification accuracy. By developing statistical methods specifically tailored to model sRNA-seq complexities, miRAQEL aims to dramatically improve the accuracy of miRNA quantification through sRNA-seq, contributing to solve challenges in the field. Appropriate statistical methodology is urgently needed to fully elucidate the role miRNAs play in many diseases and improve their biomarker potential.The fellow will receive specialized training in standard single-cell RNA-seq and statistical analysis of miRNA data from a leading research team in the field. In turn, he will bring his pipeline development and miRNA genomics expertise to implement and evaluate sRNA-seq modelling software using ground truth data and simulations. A placement will ensure transfer of this knowledge to an European start-up. The emerging unique skill set will provide him with a privileged interdisciplinary view that he
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'RESEARCH INSTITUTIONS FOR DEVELOPMENT OF USER FRIENDLY APPLICATIONS IN TELEMATICS' under Fourth Framework.

assistant: **Concept**

AQUARIUS is developing a European electronics education, training and information service for aquaculture. Its purpose is to promote availability of up-to-date specialized data in the booming fish farming sector, by boosting flexible collaboration between academic research and small and medium-sized enterprises (SMEs). This two-way exchange will be reinforced by developing telematics learning methods for professional training for fisheries. Following the development of the teaching service, the project is scheduled for validation at three academic centres and 30 SME sites in each of the three participating countries, involving some 250 persons.The AQUARIUS project aims to develop a sustainable European Electronic Education/Training and Information Service in the Aquaculture Sector. This service will be based on the integration of existing and emerging network- and telematic technologies and protocols, which facilitate flexible communication, information exchange, and collaborative work between Academic research centres and businesses (SME's). Starting January 1996, a Consortium, in which the University of Gent, Trondheim, Wageningen and Bergen participate, will build and validate a 'demonstrator' of the Education/Training and Information Service.AQUARIUS addresses the challenge of knowledge development and transfer in the rapidly growing fish farming business. Fish farming is expanding in rural Europe and is expected to grow. However, due to traditions, scientific research and education have received little attention. There is a lack of educational capacity at all levels. Furthermore, fish farmers are expressing interests for more opportunities to exchange their views and problems with fellow farmers and with the research sector. This situation creates an opportunity to