RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Fire risk evaluation to european cultural heritage: quantification of priorities and optimisation of fire protection strategies'.

assistant: **Concept**

Damage by fire is one of the most important threats to cultural heritage. The financial resources available for the fire protection are limited and priorities need to set by authorities and owners of cultural heritage. Actually no scientific tool is available to assist in the decision process. A quantitative decision method will be developed, able to prioritise between series of projects. on the basis of parameters such as value of cultural heritage, fire risk, the protection methods available - their cost and efficiency. As input to this decision method, a valuation method and risk analysis method based on statistical data on fire damage in cultural heritage will be developed. Fire protection methods will be examined on their efficiency, cost and applicability on cultural heritage.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Superconducting Mass Spectrometry and Molecule Analysis' (SuperMaMa), addressing dissemination and exploitation.

assistant: **Impact**

Mass spectrometry has become a multi-billion dollar market word-wide, because it allows one to quantitatively assess the molecular content of a sample and to retrieve molecular structure information.  SUPERMAMA now aims at breaking new scientific grounds for new technologies that shall boost the capabilities of mass spectrometry as well as of optical spectroscopy. Here we specifically target singly charged and neutral high-mass proteins.SUPERMAMA will develop, test and combine the first integrated superconducting nanowire array (SNWA) with advanced cryogenic onboard electronics in a largely re-modelled ESI-TOF-machine. The efficient detection of massive biomolecules at low kinetic energy will be an important first milestone for mass spectrometry.The development of a new generation of photocleavable tags shall allow the preparation of neutral protein beams from mass-selected ions in focused transverse high-power laser fields.  Photo-cleavage post-ionization of tagged proteins shall also be studied as a generic tool to decouple the volatilization from the charging process. This will enable the combination of a systematic analysis of neutral proteins in the gas phase with subsequent mass spectroscopy.The combination of all techniques shall open new avenues for few-photon calorimetry and single-photon recoil spectroscopy. The calorimetry studies will explore the sensitivity of SNWA detection to molecular heat. Future experiments will study the shift of molecular matter-wave interference fringes caused by the recoil of a single photon. Two industrial and three academic research teams represent a highly interdisciplinary consortium of experts from mass spectrometry, superconductor technology, integrated electronic engineering, synthetic chemistry, as well as molecular beam ph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'O2 enrichment for bio-membrane reactors for improving treatment efficiency and capacity of new and existing waste water treatment systems', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Scientific objectives and approach:A large number of existing waste water treatment plants were designed long before their construction started and have not always been adapted to take into account increases in population and pollution or technological changes. As a consequence, these water treatment plants were, in most cases, of insufficient size or technical capacity to cover the needs of the agglomerations served. Such cases have been identified by the European Court of Justice in a number of Member States. Overall, as an EU study has shown, the cost of implementing the UWW Directive in nine Member States could reach ± 201.120 million EURO s (May 1995). For France it is estimated to reach ± 12.355 million EURO for the sewage plants only, without considering the collection systems. For Greece it is estimated to reach 1.000 million EURO, for Portugal 1.300 million EURO, for Spain (only for Objective 1 regions) 5.500 million EURO and for Ireland 550 million EURO.The increase in the number of sewage plants has a significant impact on the generation of sludge. According to a Commission survey in 1994, 6.5 million tons of sludge are produced each year in the EU. Around 40% of the sludge produced in the EU comes from 1.3% of the sewage plants, from urban centres with more than 100.000 p.e. It is therefore necessary for sewage plants in large urban centres to be improved technically so that they can produce treated sludge as organic fertiliser, which is compatible with the terms defined by the UWWT Directive. The European Commission expects an increase of 50-60% in the sludge generated over the next 10 years. Additionally there are industrial processes as well which have the need of improvement regarding the activation of biological systems. These systems would have differe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Novel approaches based on bionanoscience to manipulate, study, visualize and dissociate the nucleocapsid complex of HIV'.

assistant: **Concept**

The general framework of the project NUCARCHIV is to use the recent development of nano-biotechnology to manipulate and image sophisticated in vitro reconstituted protein-nucleic acids complexes. Our goal is to bring several important advances in our understanding of the inner nucleoprotein structure (the nucleocapsid) of the human immunodeficiency virus (HIV), the causative agent of AIDS. The nucleocapsid complex plays essential roles during HIV assembly and early infection, and its modifications severely impede viral replication. The highly conserved nucleocapsid protein p7NC, the main actor of this complex, is considered as a prime target for developing new compounds with antiviral properties. Studies of nucleocapsid self-assembly, architecture and behavior in the host's cytoplasm are essential prerequisites for a complete description of HIV infection, and for the development of new anti-AIDS chemotherapies or vaccine. We will study by dynamic molecular imaging using atomic force microscopy single nucleoprotein complexes assembled from their purified partners (protein and nucleic acids templates). We will probe how these complexes are topologically modulated by the presence of viral enzymatic activities. Our goal is to provide a movie in real time showing the molecular dynamics of these complexes from virus maturation up to the late steps of early infection. We also propose to study the effect of a new molecule specifically designed to irreversibly inhibit HIV nucleocasid, with a potent application in AIDS prevention as component of next-generation of microbicids.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'UNDERSTANDING THE METABOLIC CROSSTALK BETWEEN THE MUSCLE AND THE ENDOTHELIUM: IMPLICATIONS FOR EXERCISE TRAINING AND INSULIN RESISTANCE' to be submitted under Horizon 2020.

assistant: **Abstract**

Obesity has become a leading medical disorder, which is associated with life threatening conditions such as glucose intolerance, insulin resistance (IR) and type 2 diabetes (T2D). In the maintenance of glucose homeostasis, muscle is a critical organ and current health recommendations include regular physical activity as a cornerstone in the prevention and treatment of IR/T2D. The development of exercise mimetics has been proposed as a novel therapeutic strategy, but this has failed so far. This is because we still do not completely understand the etiology of glucose intolerance and how exercise improves glucose tolerance. In particular, angiogenesis – the growth of new blood vessels from existing ones – is an early adaptive event following exercise training, but the role of the muscle vasculature in the regulation of muscle metabolism and glucose tolerance has been largely overlooked.In this project, I will investigate the metabolic crosstalk between the vasculature and the muscle to increase our understanding on how the endothelium contributes to muscle metabolism and glucose homeostasis. First, I will evaluate whether and how vessels need to reprogram their metabolism to promote angiogenesis following exercise training. Second, I will explore whether this metabolic reprogramming that results into enhanced angiogenesis is required for the muscle to allow training adaptations. I pose the novel and unexplored hypothesis that endothelial cells and the muscle intensely communicate to ensure optimal muscle function and to orchestrate muscle adaptations to exercise training via metabolic signaling. I will combine in vitro, ex vivo, and in vivo techniques using targeted and untargeted approaches to answer these exciting questions. Ultimately, I will investigate whether this c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cross-Border Regional Innovation System Integration' to be submitted under Seventh Framework.

assistant: **Abstract**

This project will provide insightful knowledge on cross-border regional cooperation in terms of how different types of proximity and levels of integration of cross-border regional innovation systems (CBRIS) impact on knowledge transfer mechanisms and levels of innovativeness in SMEs. More specifically, the study will address the following objectives: 1) Compare the effects of different types of proximity on knowledge transfer and innovativeness amongst SMEs in cross-border regions (CBRs), 2) Develop a methodology for measuring the levels of integration of CBRISs and 3) Evaluate the success of INTERREG cross-border cooperation projects in facilitating cross-border knowledge flows and innovation in the service industries, through a tourism case study. The study will utilize both quantitative and qualitative methods, as well as both comparative EU-level data and in depth case study materials (statistical, survey and interview data). This project will make an original theoretical and empirical contribution, through being the first substantial empirical study of the theoretical underpinnings of CBRISs, levels of integration of CBRs and knowledge transfer and joint innovation in tourism cross-border cooperation projects. These original contributions are highly policy relevant as the long term success of CBRs depends on collective efforts to further integration on a trans-regional level in order to develop common innovation systems. This underlines the importance of investigating the possibilities of (sustainable) socio-economic and socio-cultural development in these regions to meet the cohesion goals of the EU. Therefore, the study will provide an analysis of `best practices´ not only for the case study policy makers but also for other EU CBRs and cross-border cooperation pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nanoscale X-ray tissue imaging: understanding the pathophysiology of hepatitis E infection' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

A driving force behind biomedical innovation lies in disease prevention, diagnosis and treatment. This requires a comprehensive understanding of how pathogens exploit living organisms across molecular, cellular, organismal, and population levels. Treatment of disease often relies upon interventions that restore the normal structure and function of cells. However, it is currently challenging to visualise and quantify detailed cellular changes within whole tissues in response to disease. Soft X-ray microscopy is a novel, exciting imaging modality which enables detailed structural and chemical imaging of whole cells without fixation or dyes. This technique is currently used to image cultured cells, but has yet to be applied to the examination of cells within the intricate 3D architecture of tissue with its complex cell-cell interactions. Imaging of diseased tissue in this way is crucial to gain meaningful insight into disease mechanisms, while remaining complementary to other imaging modalities and biological assays. Project NanoX aims to tackle this challenge, by merging the skillsets of a world-leading team with synergistic expertise in infectious disease, physics and structural biology to pioneer several innovations – (i) a targeted micro-biopsy tool for rapid tissue extraction for soft X-ray microscopy, (ii) high-throughput nano-resolution 3D imaging of tissues, (iii) novel integrative data mining approaches, and (iv) unprecedented insights into the pathogenesis of hepatitis E virus (HEV), an important emerging zoonotic viral infection with no specific therapies or vaccines, in healthy and immune-compromised individuals. The scientific and technological innovations that will be developed and deployed by NanoX will revolutionize clinical diagnostics and research by prov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'UNLOCKING EFFICIENT BIO-BASED FERTILISERS FOR SOIL SUSTAINABILITY FROM UNDERUTILISED SIDE STREAMS' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

LANDFEED will focus on creating value from under-utilised waste from the agro-food industry, forestry, urban and natural waste, implementing circular and local solutions that allow waste to be valorised by placing it in a circular framework, and producing innovative biofertilisers to improve Europe's self-sufficiency. In addition to optimising and implementing innovative nutrient recovery technologies, work will be carried out on a new generation of coatings for these bio-based fertilisers, capable of improving their efficiency through controlled nutrient release mechanisms. In this way LANDFEED will contribute to a better management of the fertiliser provided, we will contribute to lower greenhouse gas emissions and a reduced impact on the environment's water resources. LANDFEED will ensure that the solutions and results of the project are locally driven through the different use cases. The use cases will consider all links in the value chain that will participate as lighthouses, serving as demonstrators and disseminators of the technologies, results and applications developed during the project.These use cases will also contribute to the objectives of the Soil Strategy by enabling the restoration of soil health through the enhancement of its specific and functional biodiversity. At the global level, the business model will be defined in its entirety, with the aim of maximising the replicability of these Use Cases and facilitating their implementation in other European areas and regions.


**Keywords:** BIO-BASED FERTILISERS, CIRCULARITY, WASTE, INDUSTRIAL SYMBIOSIS PLATFORM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'WASTE management focussing on: Knowledge and Integration to create Transnational economic development' (WASTEKIT), addressing dissemination and exploitation.

assistant: **Impact**

Project WASTEKIT anticipates on three drivers: 1. Societal &amp; economic attention for sustainability &amp; specific waste management; 2. Waste management-related regional economic development; 3. Network of networks for European innovation and competitiveness excellence. It has the following objectives: 1. Expand ambitions of regions with respect to regional economic development based on waste management RTD, innovation &amp; business creation; 2. Expand international &amp; mentoring roles of waste management-related actors; 3. Create an international role as a European network of (regional) waste management-related clusters. Result indicators are linked to the objectives. Four regions particpate: Emilia-Romagna region (Italy), Yorkshire &amp; Humber region (UK), Sofia region (Bulgaria) and Amsterdam region (the Netherlands). Regions of Knowledge experiences gave the consortium argument that 4 regions will lead to high (regional) impact potentials looking at characteristics of waste management infrastructures and RTD &amp; innovation processes. Each region is represented via triple helix actors: regional/local authority or related organisation, knowledge institution and company, including linkages with intermediary actors. 19 consortium partners contribute to WASTEKIT. AIM is proposed coordinator. This partner has coordinating experiences regarding a Regions of Knowledge project. The consortium sees fruitful waste domains like waste to energy, recycling, agricultural/bio waste, and waste prevention &amp; minimisation. The consortium invests in mentoring mechanisms; this leads to a focus on mentoring regions on waste disposal. The consortium acknowledges the methodologies &amp; approaches (like Joint Action Plan definition &amp; activation) as suggested in the call for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Intranet of Neurons: A Minimally-invasive and High-capacity Transcranial Telemetry Network for Large-scale Brain-wide Neural Recordings' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

With the increase of people suffering from various neural disorders, the need for brain-computer interfaces (BCIs) to regain sensory-motor or cognitive functions are expected to become acute in the coming decades. However, the existing BCIs can only control simple motions, e.g., grasping, and are far from realizing our vision to help paralyzed patients to walk again. This is due to the lack of a high-bandwidth wireless BCI, capable of supporting the recording from a large number of neurons with high spatial and temporal resolution, while having large spatial coverage, brain-wide.In IoN, we target to achieve a breakthrough in the ability to transfer data from intracortical recording devices, e.g., multi-electrode arrays, by developing a transcranial telemetry system that enables the efficient transfer at high data rate from such high channel count sensors (e.g., imec’s Neuropixels with 1000 channels). Most importantly, it will also fulfil the form factor required for minimally-invasive surgery, needed to minimize the surgical risk and the complications after insertion.Furthermore, IoN will significantly scale up brain-wide recordings, by introducing a new telemetry network that has the capacity to support 16 distributed recording nodes (enabling a total of 16,000 channels), which has never been demonstrated from any BCIs before.To reach these challenging targets, we propose i) a novel hybrid signal propagation method to achieve a 500Mbps data rate with a 10mm^2 implant area, 20× smaller than the state-of-the-art; ii) a completely new “spike-Aloha” protocol to maximize the network capacity, supporting 166× more channels.The technology developed in IoN will be an important transformational step to revolutionize the way neuroscientists and neurologists collect and process b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Rheological characterisation of thermoplastic composites' under Fourth Framework.

assistant: **Concept**

The project is concerned with the rheological characterisation of thermoplastic fibre-reinforced materials. Continuous fibre-reinforced materials are highly anisotropic with principal directions along and transverse to the fibres. In order to model the flow of these materials it is necessary to characterise their properties by determining the longitudinal and transverse viscosities. It has been shown that this can be achieved most easily in a rotational rheometer by off-centering octagonal samples. A rotational rheometer suitable for off-centered tests has been constructed at the University of Limerick. There is no commercial instrument that meets the desired specifications. The object of the project is to exploit the candidate's background in rheology to interpret the output from this instrument and to use it to construct a theoretical model that can be used to predict the response of the material in a forming process.