RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Applied semantics'.

assistant: **Concept**

The purpose of this project is to bring these researchers together in a Working Group, with the specific aim of improving the communication between theoreticians and practitioners. In this way we wish to focus theoreticians' attention on important practical problems as well as to speed up the application of new theoretical ideas in practice.Programming languages are the material from which every software product is built. They therefore have a huge economic impact: better programming languages will lead to higher programming productivity, reduced maintenance, and increased software reuse. Europe has great strength in programming language research, with many world leaders both in semantic theory and in implementation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploring the aggressiveness of prostate cancer to enable an individualised treatment approach' under Seventh Framework.

assistant: **Concept**

Prostate cancer is the most frequently diagnosed malignancy in the western male population and the associated socio-economic impact on healthcare is more than worrying. There is one key feature of confined (stage T2) prostate cancer that needs to be addressed with immediate urgency: its true aggressiveness. Not all cancers are life threatening and early diagnosis, although needed to improve outcome, will lead to overtreatment of patients with indolent prostate cancer resulting in unnecessary treatment-related morbidity. Therefore, methods to identify clinically significant forms of prostate cancer have to be developed. To pursue this, the initial assessment of the extent of the disease process (clinical staging) needs to be adequate. Obtaining pre-treatment representative tumor tissue (biopsies) is a major clinical challenge, as the disease is often multi-focal and heterogeneous. Accurate functional in vivo imaging modalities could guide these biopsies. Modern genomics technologies have identified numerous cancer cell-associated genetic markers being expressed in prostate cancer tissue or body fluids. Closing the gap between genomics and a non-invasive metabolic assessment of the in vivo prostate, we propose to identify new in vivo targets/biomarkers indicating confined prostate cancer aggressiveness with the underlying central hypothesis: early functional metabolic differences in different tumor foci determine whether it will grow into life-threatening prostate cancer or not. To track these early metabolic differences, the very latest magnetic resonance methodologies, including 13C MR of hyperpolarized metabolites and 1H- and 31P-MRSI of the in vivo human prostate at a field strength of 7 Tesla, will be further developed and implemented. In the well-established transla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Quantum measurement and control of non-classical mechanical states' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Mechanical systems are an essential platform for future quantum science and technologies, such as quantum interfaces, sensors and transducers, and for studies of macroscopic quantum physics. The ability to measure and control macroscopic non-classical states is an outstanding challenge. The aim of the proposed research is to obtain the motional non-classical states of a macroscopic mechanical oscillator using quantum measurement and control techniques. The first non-classical state here is a single-phonon Fock state which will be generated by controlling the phonons at a single quantum level. This single-phonon state will be heralded by single photon detection, verified using photon counting statistics, and further reconstructed using state tomography which can completely reveal the non-classicality of the state. The second non-classical state is a squeezed state where either the position or momentum is localized with better precision than the zero-point motion. Achieving the measurement-based preparation of squeezed states requires the usage of quantum measurement techniques, in my case, continuous position measurements with a speed faster than the rate at which noise couples into the position from the momentum.The experimental demonstrations of the two non-classical states will be performed on millimetre-sized macroscopic membranes with exceptionally high coherence, and even, at temperatures much higher than previous experiments of non-classical nanomechanical oscillators. This will greatly relax the requirements of quantum experiments with macroscopic mechanical systems, and potentially enables new quantum technology at room temperature. The project will pave the way towards advanced quantum state engineering by quantum measurement and control of mechanical motion, b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Risk estimation for ionizing radiation using mechanistic cancer modelling' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The main objective is risk analysis for low doses of ionising radiation using a biologically based cancer model. Important aspects are: the form of the dose-effect relationship at very low doses and the question whether it is linear, linear-quadratic or whether there is a threshold. The ultimate aim is the derivation of improved estimates of radiation risks for radiological protection.The main task for the applicant will be to continue working with the two-mutation carcinogenesis (TMC) model, to advance the model and make it applicable for other data sets and cancer in other organs, to use suitable animal data to investigate mechanistic aspects of radiological effects and to investigate suitable epidemiological data for description and model testing.The proposed research allows to consider and possibly implement new concepts such as an induction of cellular defence mechanisms and bystander effects. These important radiobiological phenomena could be included and tested within the framework of the TMC model.The applicant works in the field of low dose research since more than 8 years and is currently involved with the EU project CEC .Contract FIGH-CT-1999-00005. His range of knowledge and expertise in the field of the proposed research is interesting to be incorporated into the TMC model.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Towards the structural understanding of human telomerase' (HTR).

assistant: **Innovation**

Telomeres are repetitive nucleotide sequences rich in guanine residues located at the termini of linear chromosomes of eukaryotic organisms. Telomeres function as capping agents to protect chromosomes both from shortening at each replication cycle and from fusing with other chromosome ends or rearranging. Maintenance of telomeres length is critical for genomic stability and cell viability. Telomeres are consumed during cell division but can be replenished by telomerase, a unique ribonucleoprotein enzyme that adds telomeric repeats onto chromosome ends to maintain telomere length.  Telomerase uses an RNA template that is integral part of the enzyme and a specialized reverse transcriptase to processively synthesize the G-rich telomeric strand. The importance of the discovery of telomeres and telomerase was recognized by the Nobel Prize award in Physiology or Medicine in 2009.Telomerase is not active in normal somatic cells, but is highly active in most cancers, and is thus of interest as a target for anticancer drugs. In addition, mutations in both the telomerase RNA and telomerase proteins are associated with some diseases. Human telomerase contains a 451 nt RNA along with a variety of proteins besides the reverse transcriptase. Only a few nucleotides of human telomerase RNA (hTR) are needed as a template to elongate telomeres, but the function the rest of the RNA is unknown. By investigating the structure of the hTR, we will try to shed light to this question.The aims of the project presented for this fellowship are to determine by X-ray crystallography the three-dimensional structures of separate domains of hTR, the interaction between domains and, ultimately, the structure of the whole hTR alone and/or complexed with a reverse transcriptase protein. The knowledge of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Port solutions for efficient, effective and sustainable multimodality', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

MultiRELOAD focusses on the specific role and challenges of inland ports as multimodal freight nodes in reaching Europe’s greenhouse gas (GHG) reduction target of at least 55 % by 2030, thereby shifting a substantial part of the 75% of inland freight carried today by road in the EU to inland waterways and rail, and by increasing operational efficiency, safety and reliability of existing infrastructures through digitalization. Inland Ports are key for multimodal transport chains, both continental and maritime transport. Without efficient nodes in the hinterland multimodal transport is not possible. However, the constraints and barriers are much higher in inland ports (space, urbanisation, demand, investments) than in seaports. MultiRELOAD enhances the collaboration between different freight nodes in Europe to jointly test innovations and create favorable market conditions for multimodal freight transport solutions. MultiRELOAD will demonstrate solutions in three Innovation Areas with specific aims by 2025 – mirroring measures of the EU’s Smart Mobility Strategy: A) Smart multimodal logistics: facilitate a shift from road to rail & IWT of 5%; B) Digital & Automated Multimodal Nodes and Corridors: increase operational efficiency by 20 % raise of handling capacity; C) Innovative business models: leading to an average cost reduction of freight transport by 10%. MultiRELOAD involves highly ambitious logistics hubs, including the multimodal node duisport (DE), Duisburg's highly ambitious port and the world’s largest and most advanced trimodal inland hub terminal, and the trimodal nodes Ports of Vienna (AT) and Basel (CH). The project is backed up by additional funding & financing for better integration of the freight transport nodes into overall logistic chains of about 450 Mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Calendar life mastering of li-ion accumulator - (CAMELIA)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The challenging objective for the project is to develop new materials for lithium-ion batteries, to improve calendar life duration to more than 10 years, one of the very critical issues for a widespread development of this technology. These materials will be used for batteries in stand-by applications, as well as for hybrid vehicle batteries, and for 42-V batteries of automotive systems. This objective will be achieved together with two other issues, which provide a battery price lower than 175 EUR/kWh or 23 EUR/kW and a safe electrochemistry. Technical and cost specifications are targeted for each new material to be developed in the framework of this project in order to reach these goals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fuselage, Rear Fuselage and Empennage with Cabin and Cargo Architecture Solution validation and Technologies for H2 integration' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The FASTER-H2 project will validate, down select, mature and demonstrate key technologies and provide the architectural integration of an ultra-efficient and hydrogen enabled integrated airframe for targeted ultra-efficient Short/Medium Range aircraft (SMR),  i.e. 150-250 PAX and 1000-2000nm range. To enable climate-neutral flight, aircraft for short and medium-range distances have to rely on ultra-efficient thermal energy-based propulsion technologies using sustainable drop-in and non-drop-in fuels. Besides propulsion, the integration aspects of the fuel tanks and distribution system as well as sustainable materials for the fuselage, empennage are essential to meet an overarching climate-neutrality of the aviation sector. Green propulsion and fuel technologies will have a major impact on the full fuselage, including the rear fuselage, the empennage structure as well as cabin and cargo architecture in so far as the integration of storage and the integration of systems for the chosen energy source are concerned (H2, direct burn, fuel cell). Not only do the specific properties of hydrogen necessitate a re-consideration of typical aircraft configurations, requiring new design principles formulation and fundamental validation exercises, but they also raise a large number of important follow-on questions relating to hydrogen distribution under realistic operational constraints and safety aspects. The project will explore and exploit advanced production technologies for the integrated fuselage / empennage to reduce production waste and increase material and energy exploitation with Integrated Fuselage concept selected (maturity TRL3/4) until end of first phase in 2025. An anticipated route to TRL6 until end of the Clean Aviation programme in 2030 will ensure entry-into-servic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'A collaborative platform to document performance composition: from conceptual structures in the backstage to customizable visualizations in the front-end'.

assistant: **Concept**

The global performing arts community is requiring innovative systems to: a) document, transmit and preserve the knowledge contained in choreographic-dramaturgic practices; b) assist artists with tools to facilitate their compositional processes, preferably on a collaborative basis. The existing digital archives of performing arts mostly function as conventional e-libraries, not allowing higher degrees of interactivity or active user intervention. They rarely contemplate accessible video annotation tools or provide relational querying functionalities based on artist-driven conceptual principles or idiosyncratic ontologies.This proposal endeavours to fill that gap and create a new paradigm for the documentation of performance composition.  It aims at the analysis of artists’ unique conceptual structures, by combining the empirical insights of contemporary creators with research theories from Multimodal Communication and Digital Media studies. The challenge is to design a model for a web-based collaborative platform enabling both a robust representation of performance composition methods and novel visualization technologies to support it. This can be done by analysing recurring body movement patterns and by fostering online contributions of users (a.o. performers and researchers) to the multimodal annotations stored in the platform. To accomplish this goal, two subjacent components must be developed: 1. the production of a video annotation-tool to allow artists in rehearsal periods to take notes over video in real-time and share them via the collaborative platform; 2. the linguistic analysis of a corpus of invited artists’ multimodal materials as source for the extraction of indicative conceptual structures, which will guide the architectural logics and interface design of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integrative mechanistic and multi-omics Modelling of Antigen Presentation to predict epitope dynamics' (IMAP), addressing dissemination and exploitation.

assistant: **Impact**

The immune system can patrol cell status by recognising epitopes bound to Human Leukocyte Antigen class I (HLA-I) molecules and triggering cytotoxic T cell (CTL) activation. Epitopes arrive at the cell surface through several steps of the antigen processing and presentation pathway (APP). Despite major discoveries in the past decades, the precise dynamics of APP are still not fully understood. These dynamics, however, determine the types and quantities of epitopes and therefore regulate the CTL response. The objective of my project is the development of an APP model from gene transcription to recognition by CTL clones that captures the underlying APP mechanisms and dynamics. Current approaches are mainly machine learning-based and focus only on parts of the APP. They neglect the underlying APP dynamics and do not elucidate novel mechanisms. Therefore, they fail to predict epitopes under altered cellular states such as infection. My project overcomes this pitfall by complementing large scale machine learning approaches with mechanistic modelling to comprehensively understand the APP and enable successful epitope prediction.To achieve this goal, I will:1) develop an APP integrated computational description that combines a mechanistic model of the APP (based on detailed quantitative in vitro data) with a large-scale machine learning-based multi-omics model;2) apply the model in two therapeutic-relevant cellular systems – Measles virus infection and chemotherapy-induced senescence – resulting in the educated identification of canonical and non-canonical epitopes. This project is at the cutting edge of the research with direct application in epitope discovery for therapies such as anti-cancer immunotherapy, vaccination against infection and modulatory immunotherapies against
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bioelectrical impedance vector analysis medical device as a novel Internet of Things telemedicine system for monitoring congestive heart failure patients from home' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

IRIDEON is a Spanish-German SME, which develops and provides Internet of Things (IoT) sensor solutions based on a proprietary framework. We have partnered with HERIM, a distributor leader in the diagnostics market for lifestyle, body composition and vascular monitoring. We have been working in the development of a disruptive way to improve the monitoring of congestive heart failure (CHF) patients from home. We aim to prototype, test and commercialise an IoT telemedicine system based on bioelectrical impedance vector analysis (BIVA): CardioBIVA.One in five people in Europe will experience heart failure. CHF is the most common cause of hospitalization in people aged over 65, and half of these die 5 years after the first hospitalization. Heart problems cause 29% of total global deaths, and in Europe 47% of all deaths- over 4 million/year. CHF costs the EU economy €60 billion a year.We have a clear business opportunity, as an IoT telemedicine system that would enable an easy and frequent monitoring of a reliable physiological indicator to CHF in the home environment is expected to substantially reduce hospitalizations and, as a result, lower medical costs and impact on life.The telemedicine industry has become an integral part of the European economy, investing approximately €200 billion a year. The shipments of telemedicine “gateways” for CHF are expected to reach 561,000 in 2015 and over 3.5 million units by 2020.We already have the primary distribution covered by HERIM’s consolidated sales network in Iberoamerican countries, complemented by IRIDEON’s e-commerce channel. The secondary channel will be other Medical Equipment and Supply companies and Insurance companies.With the exploitation of CardioBIVA we expect to create 35 new job positions, internationalize and enter