RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'EU centralized chimpanzee facility for preclinical HIV-1 vaccine development'.

assistant: **Innovation**

The objective of the EUCF-PHVD programme provide highly skilled scientific personnel with primate research expertise with the resources for the stepwise development and evaluation of safe, effective viral vaccines, and specifically vaccines for the prevention of HIV- 1 infection and development of AIDS.Phase A" of the EUCF-PHVD programme is a limited part of the EUCE-PHVD proposal ranked number 1 by the European Commission in 1995 against a large number of other competitive proposals in the same area. Due to limited funds only phase "A" (approximately 1/5th) of the scope of the entire proposal could be initiated. The Commission has requested that the remainder of the EUCF-PHVD programme (phase "B") be resubmitted (the same objective but additional vaccines/strategies which need to be evaluated) for the second round of BIOMED II. The broad aims of the EUCF-PHVD programme are to provide European researchers with a critical competitive research resource for the development and evaluation of Vaccine Biotechnology initiatives. It is the aim to accelerate the preclinical development and evaluation of European vaccine candidates as effective products to the clinic. This expert staff will utilise the unique resources of the Biomedical Primate Research Centre and lend their expertise to provide European Researchers with valuable assistance to facilitate strategic development and to improve vaccine efficacy. All non human primate (NHP) studies will all be performed at the Centralised Facility for the sake of standardisation and comparison, including cell-mediated immunity and virus detection assays. Serologic assays will be performed by the collaborating partners whenever possible, but retrospective analysis and comparison of responses across or between studies will be performed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The role of pericytes in central nervous system scarring and fibrosis'.

assistant: **Objectives**

Damage to the central nervous system (CNS) often leads to persistent functional deficits, causinggreat individual suffering and enormous cost to society. The manifestation of these deficits isbelieved to be associated with the scar tissue that forms locally at lesions, causing permanent tissuealteration and blocking regeneration.Research on CNS scar tissue has primarily focused on astrocytes and it is often referred to as theglial scar. However, although it has received much less attention, there is also a connective tissue orstromal, non-glial, component of the scar.While studying spinal cord injury-induced scarring, I recently discovered a new subpopulation ofperivascular cells, named type A pericytes, as a major source of connective scar tissue. Type Apericytes are embedded in the vascular wall but proliferate and leave the blood vessel upon injury,differentiating into fibroblast-like cells that deposit extracellular matrix to seal the lesion and formthe persistent stromal scar core.The aim of the proposal is to determine whether type A pericytes are a general source ofpathological connective tissue in the CNS, to understand the nature of type A pericytes, and touncover the signaling mechanisms mediating their recruitment. By comparing several differentinjury and disease models the proposed research intends to uncover common mechanisms ofscarring and fibrosis and to identify new targets for human treatment after CNS injury.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Pyrolysis oil for heat generation: verification of a second generation pyrolysis process ('PYROHEAT')' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Among the biomass-derived bio fuels, pyrolysis oil (PO) appears to be the more cost effective. Pilot plants installed in Europe suffer of many defects typical of young technologies. Moreover, the oils have unfavourable fuel properties. The proposals intends to advance the pyrolysis technology developing new concepts for the pyrolysis process and making technological improvements in the pilot plant that will used to assess the concepts. The use of the oil in small and large-scale thermal boilers is foreseen to verify the fitness of PO to substitute heavy and light fossil fuels and to assess the environmental impact.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'dSense – Self adapting, cost efficient method for detecting context of a mobile device  and a mobile device with a context detection module' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The project is going to launch in existing mobile devices a software system and/or module for a context detection to ensure environmentally and costly efficient required service’s results for users. The R&D Department of Binartech has developed basic substantial assumptions of these method,it is protected by international patent in Poland, Europe (Germany, France,UK),Japan, U.S.A. India (patent pending).The disruptive solution focuses on more effective,faster and apt fit of mobile services to user's needs, which is possible thanks to a device being aware of a broader context in which it is used atm (eg. when driving a car or walking). Our solutions provides much better compromise between accuracy and energy usage. dSense is distinctive from available solutions because of its self-adapting skills, which are crucial due to large variety of devices and environments people use their mobile phones. This means that even for ca. 5% user of mobile devices having every-day problems with accuracy of context awareness of mobile applications, it will be easy to get self-learning correct results in a short period of time using low energy-consuming sensors.We have identified three areas of benefits according to understanding of the user, i.e.: final users of mobile devices,application developers/investors, and mobile devices producers which mount the module in their devices.Added values are:operating time of the battery (better up to 60%), automatic adaptation of the context detection system to all applications being installed to the mobile devices, accuracy of applications’ results and speed of delivered applications’ results. Feasibility study will enable us to verify the technological feasibility and economic viability of launching dSense on EU’s market, which will contribute to s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Exploring Musical Possibilities via Machine Simulation'.

assistant: **Concept**

"Whither Music?"" was the motto of Leonard Bernstein's 1973 lectures at Harvard, where he analysed the (inevitable?) process that led to what he called the 20th Century Crisis of Music: the gradual decline of tonality, driven by a takeover of  tonal ambiguity in the late 19th and early 20th centuries, eventually leading to complete abandonment of tonality in Schönberg's dodecaphony.WHITHER MUSIC? is a project that aims to establish model-based computer simulation (via methods of Artificial Intelligence, Machine Learning and probabilistic modelling) as a viable methodology for asking questions about musical developments, possibilities and alternatives - for musicology, for didactic purposes, for creative music exploration scenarios. Computer simulation here means the design of predictive or generative computational models of music (of certain styles), learned from large corpora, and their purposeful and skilful application to answer, e.g., ""what if"" questions, make testable predictions, or generate musical material for further analysis, musicological or aesthetic. Making it possible to do this in highly controlled and musically 'valid' ways will require massive research on machine-learning-based music modeling, to obtain generative models that are stylistically faithful, tightly controllable, transparent and explainable - in this way advancing the field of Music Information Research (MIR). At the same time, this will open entirely new possibilities for musicological research, for music education, and for creative engagement with music, some of which will be further explored, in the form of musicological studies, didactic tools and exhibits, and public educational events.To attain this vision, we will need to thoroughly re-think the way music is modeled in AI systems. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Broadening Expertise for YOung Researchers iN aDvanced Cell & Gene Therapies' in the context of a Horizon Europe call.

assistant: **Objectives**

BEYOND is a cutting-edge, International Postdoctoral Training Programme on Advanced Therapy Medicinal Products (ATMP) designed to promote excellent training through interdisciplinary, intersectoral, and cross-border mobility and collaboration. Coordinated by Fondazione Telethon (FTELE), BEYOND aims to tackle the critical skills shortage in the ATMP sector, addressing the pressing demand for intersectoral professionals capable of confidently navigating the full translational pathway of these drugs - a rapidly evolving domain at the forefront of global healthcare innovation.Over 60 months, BEYOND will recruit 35 postdoctoral researchers through 2 competitive calls, offering 3-year fellowships that blend excellent academic science with immersive exposure to all facets of the ATMP development ecosystem, tailored to meet each fellow’s interests and career goals. The Programme combines fundamental and translational research training - in cellular and molecular biology, gene and cell therapy, genomics, computational modelling and AI-protein design - complemented by tailored career development support, empowering fellows to succeed in academia and beyond.BEYOND is uniquely positioned to make a lasting impact by setting new standards for postdoctoral training: it leverages the leadership in the field of FTELE’s institutes (SR-Tiget and TIGEM), and the synergistic strengths of 3 academic implementing partners across Europe (UK, Sweden, Slovenia), alongside key associated academic/non-academic partners like EATRIS, Medicon Village, Assobiotec and Schiller & Mertens. With a holistic approach on career development, BEYOND will empower researchers to become future leaders in the ATMP field. Fully aligned with EU strategic priorities and embedded in dynamic national and regional R&I e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Critical natural capital and the implications of a strong sustainability criterion.'.

assistant: **Concept**

15 Working Papers were completed, the extra one being a supplementary paper on the analytical framework, which was developed. The other WPs were delivered broadly as envisaged. Agreement in principle has been reached to turn them into Special Issues of two academic issues, work on which is now underway.National Workshops were organized, or are forthcoming, in all but one of the partner countries. A wide range of policy makers and other academics attended the workshops.The overall goal of the project is to gain insights and understanding that are relevant to environmental policy concerning the application of the strong sustainability criterion to the use of the environment and its resources. In this project, environmental sustainability is defined as the maintenance of those environmental functions which play an important role in sustaining major ecosystems or natural processes, or which make a substantial contribution to human welfare. The concept of strong sustainability derives from a perception that certain 'critical' components of natural capital make a unique contribution to welfare and must therefore be preserved if their functions are to be sustained The objectives of this project which will contribute to the attainment of its goal are: 1. To construct a theoretical framework for the identification of critical natural capital (CNC), the maintenance of which is required for strong sustainability to be achieved. 2. To classify the CNC of each of the countries represented in the project consistently with the theoretical framework of Objective 1, though also clearly reflecting each country's different environmental endowments and capacities. 3. To choose a particularly significant example of CNC in each country, and investigate the socioeconomic implications of apply
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Solid-state reactions for thermal energy storage' to be submitted under Horizon 2020.

assistant: **Abstract**

In this project proposal reversible solid-state chemical reactions (eutectoids, peritectoids) are proposed for the storing of thermal energy at high temperature (300-800 °C). The development of a novel heat storage concept, based on solid-solid reactions, proposed in this project, could contribute to open new scenarios in the thermal energy storage field. To the best of our knowledge, the use of this class of reactions for TES applications has not been explored so far. The goal of this study is the identification of solid-state reactions fulfilling a large number of scientific and technological requirements (high storage capacity, good thermal conductivity, mechanical and chemical stability, complete reversibility of a charging/discharging cycles etc.). For this scope, an interdisciplinary research strategy will be followed involving materials chemistry, physics and engineering disciplines to achieve a complete overview of their behaviour starting from basic research challenges, focused on the material development and characterization (reactivity, stability, kinetic, reversibility, heat and mass transfer etc.), up to arrive to the investigation of their feasibility in real applications (e.g. concentrated solar power technologies (CSP) and waste heat recovery). During the project a two direction transfer of knowledge will be applied. On one side, an intense training will be offered to the applicant by the host laboratory with the objective to increase his scientific and managerial skills. Secondment in one established European technological center with recognized international expertise in concentrating solar plants (CSP) technologies is also planned. On the other side, the applicant will make available the knowledge and competences matured along his career both to give
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dissecting GLP-1 receptor internalization pathways using genetic and pharmacological tools' (INTERGLP1) under Horizon 2020.

assistant: **Objectives**

Glucagon-like peptide-1 is a key regulator of insulin and blood glucose release. The cognate receptor, the glucagon-like peptide-1 receptor (GLP-1R), a class B GPCR is a major drug target for type 2 diabetes. Agonist-induced internalization is a major regulatory mechanism for GPCR signalling. Interestingly, GLP-1R internalizes via a mechanism that is distinct from the canonical beta-arrestin mediated pathway. However, the details of the exact mechanism is largely conflicting and poorly understood for GPCRs in general. The present project aims to develop genetic and pharmacological tool box to dissecting the intracellular pathways leading to GLP-1R internalisation. To do this, I will generate a series of HEK293 cells where key proteins involved in a range of GPCR internalization pathways have been systematically removed by CRISPR/Cas9 genome editing. These cell lines will complement the already existing G protein alpha subunit and beta-arrestin knockout HEK293 cell lines to generate a highly efficient toolbox to study pathways and mechanisms involved in GPCR signalling, internalization and regulation. In the present project, I will utilise theses cell lines to dissect pathways leading to GLP-1R internalization and endosomal signalling. To understand the role of bias in the complex signalling profile of GPCR, I will also develop conformationally selective nanobodies using the yeast surface display platform. Importantly, we will make the cell lines and pharmacological tool compounds available to the scientific community enabling similar studies on a much wider range of GPCRs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Integration of efficient downstreaM PRocessEs for Sugars and Sugar alcohols', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The IMPRESS project will demonstrate a new hybrid biorefinery process for the first time, integrating disruptive upstream and downstream technologies developed by the project partners. A main objective of the project is to develop and upscale separation and purification methods for the upstream process and modular downstream processes. New purification and separation methods will enable to produce new products, like xylitol, erythritol, bio-based ultra pure monoethylene glycol and monopropylene glycol and lignin derived activated carbon. All the process routes developed and up-scaled in the project are integrated to the IMPRESS concept by executing a Conceptual Process Design (CPD) of the different unit operations and then the CPD of integrated IMPRESS concept. It’s expected that the new purification and separation methods, and new high value products combined with benefits deriving from the integration will decrease OPEX by by 25 % and CAPEX by 20 %. In addition, the GHG emissions are expected to decrease more than 20 %. The decrease of CAPEX and OPEX will be calculated by CPD and the environmental performance of the IMPRESS concept and the developed products are evaluated by performing a Life Cycle Assessment (LCA). The results of the project and benefits of the IMPRESS concept will be disseminated to relevant stakeholders by preparing education modules concerning individual unit operations, the integrated process, and methodology such as LCA that will be easily integrated in existing curricula and modules for undergraduate level and lifelong learning programmes.


**Keywords:** Integration, unit operations, separation, purification, glucose, carbohydrates, sweeteners, MEG, MPG, lignin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Authentication methodologies for metal artefacts based on material composition and manufacturing techniques' under Sixth Framework.

assistant: **Concept**

The forgery of original works of art and fraudulent dealing of counterfeits has been a problem ever since ancient times, a global challenge, at level with trafficking of weapons, drugs, and human beings. International legal agreements, (UNESCO convention, EU directives) are hardly implemented.The dimension has expanded, resulting in a large number of authentication demands from CH stakeholders. Authentication today is mostly based on human science interpretation, with no systematic integration of data, incomplete solutions that cannot match results achievable by material characterization & technological studies.The need for objective, reliable, validated authentication protocols and tools is answered by the proposed research: the important community of museums, conservation services, law enforcement agencies will profit from an integrated multidisciplinary scientific approach, foreseeing the use of most advanced material investigation techniques, related to metal artefacts (precious and non-precious) through a systematic integration of adequate competencies, not yet projected into the ERA's excellence.Research strategic objective is the innovative integration of non invasive techniques x objective authentication of metal artefacts (utilitarian + ornamental), based on material composition & description of manufacturing techniques to be achieved by exploiting the most advanced analytical techniques and by developing & validating portable instrumentation based on selective composition markers detection and characterization of technological fingerprints.The multidisciplinary approach involves research centres, academia, Museums, Conservation services, super intendencies, SMEs, EEIG, Law Enforcement Agencies, Civil Protection Bodies. Integrated Authentication Methodologies (