RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Small-angle X-ray scattering at high brilliance European synchrotrons for bio- and nano-technology' (SAXIER), addressing dissemination and exploitation.

assistant: **Impact**

This is an initiative of European groups involved in exploring novel scientific applications for the new generation of small-angle X-ray scattering (SAXS) beamlines at high brilliance synchrotron facilities. SAXS is a powerful technique providing unique information on the nanostructure and kinetics of condensed matter. With the upcoming of undulator beamlines at the first European 3rd generation synchrotron (ESRF), novel SAXS applications in the areas of very short time-scales (down to micro-seconds), v ery broad resolution range (from nanometer to micrometer) and ultra-small beam sizes (down to nano-scale) have been demonstrated. SAXS beamlines are available, to be upgraded or constructed at all major existing and planned European synchrotrons. The pr esent proposal joins the efforts of these facilities in the design of novel hardware and software components for the new beamline generation. The design and feasibility studies are envisaged on principally novel user-oriented solutions with clear Europea n added value. These include optical elements for nano-focussed beams and unique sample environment options for multidisciplinary studies (nano-manipulation, on-line micro-Raman, microspray and gel-filtration, cryo- and microfluidic devices). An integrat ed software system for automated data analysis will be created. The prototypes developed will set new standards for synchrotron SAXS in Europe allowing automated large-scale studies and cutting edge experiments. The infrastructure will be of particular i nterest for structural biology of proteins and macromolecular machines, in the studies of biological and advanced nanomaterials (e.g. tissues, fibroins, biomimetic devices, catalysis, composite materials), of crystallization and phase transition phenomena, surface chemist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Scaling-up Packages of Interventions for Cardiovascular disease prevention in selected sites in Europe and Sub-Saharan Africa: An implementation research (SPICES Project)' (SPICES).

assistant: **Concept**

The overall research objective of the SPICES project is to implement and evaluate a comprehensive CVD prevention and control program in five settings: a rural & semi-urban community in a low-income country (Uganda), middle income (South Africa) and vulnerable groups in three high-income countries (Belgium, France and United Kingdom) as well as to identify and compare the barriers and facilitators across study contexts. The project will be evaluated using a mix of formative assessments; pre/post and  trial designs. At the beginning of the project, we will conduct baseline assessments including literature reviews, formative studies, household surveys (where feasible) and learn lessons from other projects to understand healthcare and lifestyle practices, barriers, and facilitators.  A cost-effectiveness and cost benefit analysis will be included. In addition, the teams will conduct site exchanges visits to learn from each other and organise policy dialogues to ensure sustainability and maximise impact of the interventions. The implementation outcomes—acceptability, adoption, appropriateness, feasibility, fidelity, implementation cost, coverage, and sustainability will be evaluated – in order to understand the factors affecting the implementation, the processes, and the accruing results. The intervention of the SPICES project will aim to: (1) improve patients ’risk profiles (LDL-cholesterol, blood pressure, HbA1c (among patients with diabetes), modify lifestyles (diet and exercise and smoking cessation) and achieve recommended cholesterol, blood pressure and glycaemic control targets; (2) increase proportion of patients receiving appropriate BP, cholesterol and diabetes medication; (3) and mitigate the number of people developing complications such a stroke and myocardial i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Elucidation of the molecular and functional basis of disease phenotypes in the rat model' (ELABORATE) targeting Seventh Framework.

assistant: **Abstract**

Recent genetic studies have identified hundreds of susceptibility genes for common human diseases but genetic effects are small and identifying underlying mechanisms remains challenging. Rodent models offer significant advantages for analysis of disease phenotypes. Advances in genome resources and gene targeting have increased the attractiveness of the rat model for genetic studies but progress has been hampered by absence of relevant rat genome sequences.We recently sequenced the genome of the spontaneously hypertensive rat (SHR) and will shortly have completed the Wistar Kyoto (WKY) rat sequence. The SHR genome contains over 750 genes that are completely or partly deleted, or have a frameshift in their open reading frame. These sequence variants, along with variants controlling dysregulated gene expression that we characterised previously, most likely include the major determinants of SHR cardiovascular and metabolic disease phenotypes.We shall determine the functional consequences of these variants by creating and phenotyping transgenic and knockout rats on the SHR and WKY genetic backgrounds, using transposon-mediated transgenesis and zinc-finger nuclease-mediated gene deletion recently shown to be highly efficient in rats. Genes will be prioritised for study by statistical and informatic analyses using our extensive physiological, gene expression and linkage data in these rat strains, and by comparative analysis with data from human genome-wide association studies. Confirmed rat disease genes will be tested for conserved functions in humans.These proposals provide a systematic route to elucidating the molecular and functional basis of disease phenotypes in SHR and WKY rats, and for translating these findings to advance understanding of common human diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Design of a monolithic matter-wave interferometer for gravity sensing and navigation' to be submitted under Horizon 2020.

assistant: **Abstract**

Interferometry is a universal, precision metrology tool. Matter wave interferometers have been developed over the last decades and are now used as gravimeters for prospecting and geoscience and in fundamental studies, i.e. of quantum coherence, gravitational constant measurements and dielectric response. Research is ongoing  for use as accelerometers for long distance, under-water navigation and for dark matter and gravitational field exploration in space. Monolithic interferometers, where diffraction slabs are cut into a single crystal, are particularly attractive in the latter contexts due to their unsurpassed thermal and mechanical stability. However, up till now no monolithic interferometers for atoms have been realised, because atoms cannot penetrate the diffraction slabs. This project presents a completely new idea: A reflective monolithic atom interferometer with reflective slabs cut into a silicon monolith. Two configurations are considered: i) Surface Diffraction: Scattering at the intermolecular potential of Si(111)-H(1x1) (can be used with light atom beams only) and ii) Quantum diffraction: scattering at the dispersion potential from a blazed grating (can be used with all atom beams). The aim of this project is to provide a theoretical model of the new interferometer based on realistic experimental conditions and use the model to evaluate the new instrument for dark matter/gravitational waves exploration, prospecting and navigation applications. The project connects interdisciplinary expertise - the applicant Dr. Fiedler, expert on the theoretical description of matter-wave optical devices, Prof. Holst, expert on matter wave instrumentation, machine learning expert, Ass. Prof. Parviainen and theoretical particle physicist Prof. Kersten. The applicant will lea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Water Works 2016-2020 in Support of the Water JPI (WaterWorks2015) - Sustainable water use in agriculture, to increase water use efficiency and reduce soil and water pollution'.

assistant: **Concept**

The WaterWorks2015 proposal responds to the Horizon 2020 (H2020) Societal Challenge 5 2015 Call topic Water-3 [2015]: Stepping up EU research and innovation cooperation in the water area.WaterWorks2015 aims at pooling resources from the 32 participating research programme owners / managers of 23 countries to implement a joint call for proposals, with EU co-funding in the area of sustainable water use in agriculture and forestry. It's a collaboration between the Joint Programming Initiatives (JPIs), Water JPI “Water Challenges for a Changing World” and FACCE JPI “Agriculture, Food Security and Climate Change”. Achieving a “sustainable water use in agriculture, to increase water use efficiency and reduce soil and water pollution” is at the intersection of the two JPIs, contributing to the implementation of their respective Strategic Research Agendas. WaterWorks2015 includes 9 organisations from associated and third countries in an effort to reinforce international cooperation. Additional Activities will also be carried out to further support the implementation and strategy of the Water JPI.The overall aims include:• Increasing the value of relevant national and EU R&D funding by concerted and joint planning, implementation and evaluation of national research programmes; • Pooling financial resources from participating states towards the definition and implementation of a Co-funded transnational and multi-disciplinary Call for research and innovation proposals. The aim of the Call will be to support the implementation of initiatives and environmental policies, in particular those related to water and agriculture & forestry, as a way to increase water use efficiency and to reduce soil and water pollution;• Overcoming the fragmentation of European water and agriculture/fores
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced aerodynamic flow control using mems (AEROMEMS II)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

AEROMEMS II aims to undertake industrial scale wind tunnel demonstrations, engineering integration and cost/benefit assessments of MEMS flow separation control technology applied to improving the performance of wing high-lift systems, engine nacelles and turbo-machinery components . Further development of the prototype MEMS flow sensors and actuators developed under the previous EU funded AEROMEMS project will be undertaken to improve their efficiency and to address the issues of robustness associated with engineering integration. Finally, aerodynamic prediction tools will be developed and validated for use during future full-scale development. The project has 4 discrete but highly inter-linked Work Packages, involving 16 partners from industry, research organizations and academia from within 4 member states.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cell and gene therapy based strategies to correct the bleeding phenotype in Hemophilia A' (2007-2013).

assistant: **Innovation**

Currently, haemophilia A cannot be cured. To prevent major bleeding episodes in haemophilia, human Factor VIII (FVIII) protein must be frequently administered as prophylaxis or on demand. This treatment is complicated by its high cost and development of antibodies that neutralize FVIII activity in 20 to 30% of the patients. Therefore, permanent solutions in the form of cell and gene therapy are very attractive for haemophilia A. Recently, we demonstrated in a murine model that liver sinusoidal endothelial cells (LSEC) produce and secrete FVIII, although not exclusively. We have also found that these mice can be treated by reconstitution with wild-type bone marrow, indicating that bone marrow-derived cells, of hematopoietic, mesenchymal or even endothelial origin, can produce and secrete FVIII.  Based on these findings in mice, I propose that human LSEC, umbilical cord blood cells, and bone marrow cells might be suitable sources of FVIII to be used for cell replacement therapy for haemophilia A. To advance opportunities for cell and gene therapies in haemophilia A and for identifying additional cell sources of FVIII, I intend to explore whether replacement of liver endothelium and bone marrow in immnocompromised Haemophilia A mice with healthy human cells will provide therapeutic correction. Recently, the possibility of reprogramming mature somatic cells to generate induced pluripotent stem (iPS) cells has enabled the derivation of disease-specific pluripotent cells, thus providing unprecedented experimental platforms to treat human diseases. Therefore, I intend to study whether the generation of patient-specific iPS cells may be applied to cell and gene therapy of coagulation disorders and in particular for the treatment of Haemophilia A. Studies with these novel target
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Vascular and Aymloid Predictors of Neurodegeneration and Cognitive Decline in Nondemented Subjects', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Alzheimer’s disease (AD) is the most frequent cause of dementia that affects one in 14 persons over the age 65 years and one in six persons over the age of 80 years.Increased deposition of the protein beta-amyloid (Aß) is a core brain pathology of AD that occurs years before the onset of clinical symptoms of dementia. Together with Aß, cerebrovascular disease, visible as on a MR image as white matter abnormalities, frequently co-occurs. A major question is whether Aß and cerebrovascular disease independently from each other predict disease progression and cognitive decline.The overall goal of the combined amyloid PET and MRI study is to assess how Aß pathology and vascular white matter damage contribute to cognitive decline through particular neuronal networks at an early stage of the disease.To this end, we will assess in a prospective 4-year longitudinal neuroimaging study 80 subjects with mild cognitive impairment (MCI) of episodic memory or executive function and 50 elderly cognitively healthy subjects (HC).Brain changes in association with Aß (florbetaben PET) and white matter degeneration (MRI, DTI) will be assessed in two major networks 1) temporo-parietal network that is typically associated with episodic memory, and 2) a subcortical-prefrontal network that is typically associated with executive function. Specifically, florbetaben PET binding and volumes of WMH and lacunes at baseline will be tested as predictors of fiber tract degeneration (DTI) and grey matter atrophy of those networks and cognitive decline during annual follow-up assessments.We expect that the results of this study will provide us with a clear understanding of the joint effects of the Aß and vascular white matter pathology on brain degeneration to predict cognitive decline during an early dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Games Realising Effective and Affective Transformation (societal and cultural domains)', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Games Realising Effective & Affective Transformation (in Societal and cultural domains)Research and innovation in the GREAT project will generate new knowledge of the actual and potential impact of games on European society and new understandings of the innovative uses of games to support the social engagement of citizens. Leveraging the central role of games in contemporary culture, it combines academic studies and practical experimentation with novel applications of games. Using collaborative design and citizen science methods, it brings together researchers with expertise in the areas of games, data analytics, and policy in an integrated investigation, articulated by case studies of the use of games in facilitating dialogue between citizens and policy stakeholders (policy makers, policy implementers, political parties, campaigning organisations and affected citizens). The context for the research is the climate emergency, and each case study is a research cycle addressing a policy issue and research questions, with multiple pilots and quantitative and qualitative research activities. An important aspect of the method is to place games in an authentic context, so that players are aware that their activities have real-world implications, and to close the loop by including interactions with policy stakeholders. Agile methods are applied to adapt games from existing platforms, for use as research tools: (a) short games deployed at scale in hit mobile games, generating quantitative data and reaching 3 million players, and (b) longer collaborative games based around social dilemmas with small groups, generating in-depth qualitative data. Research outcomes include publication of research findings in journal papers, a method for using games to rapidly obtain data and insight
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Access to the uk astrophysical fluids facility' to be submitted under Fifth Framework.

assistant: **Abstract**

Description:The UK Astrophysical Fluids Facility (UKAFF) is the largest supercomputing facility in Europe dedicated to a single scientific field. It is housed within the Department of Physics & Astronomy at the University of Leicester. The department is a world leader in Astronomy, Astrophysics and Space Science research. UKAFF currently operates a 128-CPU SGI Origin 3800 supercomputer which is used for research in the field of Theoretical Astrophysics. This was the first large Origin 3000 series computer to be delivered in Europe and provides significant performance improvements over the older Origin 2000 series. UKAFF has recently added an older 24-CPU Origin 2000 which is used extensively for code development. UKAFF was initially funded by the UK government's Joint Research Equipment Initiative (JREI), receiving 2.41 million from the 1999 round the largest single award. This funding was matched by the computer company SGI. Further funding has been received from the Particle Physics and Astronomy Research Council (PPARC), the Leverhulme Trust and the EU Fifth Framework Programme.Application:The access to UKAFF offered through the EU's Fifth Framework Programme is aimed at researchers in astrophysical fluid dynamics who do not have experience of, or other access to large supercomputers. The primary benefit to these researchers is a visit to the facility where they receive training and support in developing and parallelising their numerical codes. A modest allocation of cpu hours is made to successful applicants. Applications to use the facility under this programme are made using forms provided on the UKAFF website - www.ukaff.ac.uk. Application rounds are quarterly with closing dates of 1st February, 1st May, 1st August and 1st November. Further details can be obtaine