RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Optimisation and upscaling of self-cleaning surfaces for automotive sector by combining tailored nanostructured machined injection tools and functional thermoplastic nanocompounds', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Progress in nanotechnology benefits achieving new functions and features for numerous new products and applications through the knowledge-based tailored properties. However, despite these special features, there are many challenges to transfer real applications into our daily life.  NANOCLEAN project seeks to demonstrate the up-scaling of tailor-made nanostructured based self-cleaning feature on plastic components through cross disciplinary approach. In particular, the proposed technology is based on stable and durable so-called lotus-effect from both chemical and physical methods such as nano/micromachining - templation technologies and nanomodified materials. Therefore, the project will evaluate and assess the large scale production of advanced nanostructured plastic components for automotive sector, with controlled wettability properties, by combining the application of specific nano-microstructured surface through enhanced energy femtosecond laser pulse, specialty formulated and modified polymers and industrially implanted injection moulding technology.  Furthermore, due to versatility of proposed process, an effort will additionally be carry out to promote this technology of controlling the wetting properties of large volume market plastic products for application to very many different systems where liquid and solid phase are in contact (consumer products, medical products, microfluidic, electric/electronic appliances…...).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Opening new frontiers in multi-scale evolution of collider events: a dual pathway to precision' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

For the decades to come, the pioneering investigation of the fundamental laws of nature at the Large Hadron Collider (LHC) and at future collider experiments will rely on the interpretation of complex scattering events by means of accurate theoretical calculations, which are instrumental to find small signals of elusive new phenomena. These calculations must describe the evolution of the system from the few particles produced in the high-energy scattering to the tens or hundreds of low-energy particles observed in the detectors.  This proposal aims at transforming the core of our theoretical understanding of such a multi-scale evolution, which nowadays is often too inaccurate to cope with the striking experimental precision.  The goal of JANUS is to develop innovative ideas and theoretical methods to advance significantly both approaches to the problem: Resummations and Parton-Shower-Monte-Carlo (PSMC) generators.  JANUS will establish a deep connection between the two fields, resulting in novel technology for the accurate modelling of multi-scale effects. Its main objectives are:  - To formulate new theoretical methods to tackle the resummation of complex collider observables in reactions with more than two emitters and scales with state-of-the-art accuracy.    - To lay the theoretical foundations for a new generation of PSMC algorithms, capable of describing accurately the hard scattering and subsequent parton-shower evolution for reactions with different jet multiplicities with a new standard of precision.This technology will be applied to obtain state-of-the-art theoretical predictions for a broad range of critical observables in the important fields of Higgs and jet physics, enabling their optimal exploration at the LHC and future collider experiments.


**Keywords
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Neurocognitive mechanisms of human anxiety: identifying andtargeting disrupted function' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Within a 12 month period, 20% of adults will meet criteria for one or more clinical anxiety disorders (ADs). These disorders are hugely disruptive, placing an emotional burden on individuals and their families. While both cognitive behavioural therapy and pharmacological treatment are widely viewed as effective strategies for managing ADs, systematic review of the literature reveals that only 30–45% of patients demonstrate a marked response to treatment (anxiety levels being reduced into the nonaffected range). In addition, a significant proportion of initial responders relapse after treatment is discontinued. There is hence a real and marked need to improve upon current approaches to AD treatment.One possible avenue for improving response rates is through optimizing initial treatment selection. Specifically, it is possible that certain individuals might respond better to cognitive interventions while others might respond better to pharmacological treatment.  Recently it has been suggested that there may be two or more distinct biological pathways disrupted in anxiety. If this is the case, then specification of these pathways may be an important step in predicting which individuals are likely to respond to which treatment. Few studies have focused upon this issue and, in particular, upon identifying neural markers that might predict response to cognitive (as opposed to pharmacological) intervention. The proposed research aims to address this. Specifically, it tests the hypothesis that there are at least two mechanisms disrupted in ADs, one entailing amygdala hyper-responsivity to cues that signal threat, the other impoverished recruitment of frontal regions that support cognitive and emotional regulation.Two series of functional magnetic resonance imaging experiments wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tackling fibrosis and inflammation in LAMA2-RD by in vivo modulation of a novel modifier gene' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Merosin-deficient congenital muscular dystrophy (LAMA2-RD) is caused by mutations in the LAMA2 gene, coding for the 2 subunit of laminin-211 (merosin). Typically, LAMA2-RD patients with absent merosin are clinically severe and unable to walk, while those producing a partially functional merosin are clinically milder. I identified a unique family in which the oldest of two affected siblings shows a novel and extremely mild phenotype despite the complete lack of merosin. This patient is still ambulant at 33 years with no respiratory insufficiency or cardiomyopathy. Notably, this patient carries the same LAMA2 loss-of-function mutation as the sibling who followed the typical severe disease course. Hypothesizing that genetic modifier(s) in the atypical patient mitigate the consequences of complete merosin deficiency via a novel mechanism, I isolated unique ultra-rare polymorphisms in genetic factors related to genes expressed in the atypical patient muscle but not in muscle of non-related LAMA2-RD patients, and I identified a novel candidate modifier controlling both fibrosis and inflammation (key drivers of LAMA2-RD pathogenesis). Given that this modifier is severely upregulated in the control LAMA2-RD patients but highly downregulated in the atypical patient, I will decrease its expression in the severely affected LAMA2-RD mouse model DyW/DyW by using the CRISPR-interference tool delivered by a single AAV9. I will then assess motor strength and endurance in treated mice. Finally, I will isolate highly affected muscles and sciatic nerve to characterize any molecular and morphological change occurring in these tissues upon modulating the modifier gene expression. I expect to observe functional improvement in LAMA2-RD animals, thus ameliorating their phenotype. The proposed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Characterization of the chromosome 22 region altered in malignant rhabdoid tumors' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content Rhabdoid tumors (MRT) are highly malignant tumors occuring in young children. They can occur in renal or extra-renal localization and are frequently difficult to diagnose. Cytogenetics and molecular biology have indicated that MRT recurrently demonstrate deletion of the proximal part of chromosome 22. This strongly suggests that oncogenesis of these tumors is linked to the inactivation of a presently unknown tumor suppressor gene localized on chromosome 22. This project is aimed at the precise characterization of an MRT cell line, established in the laboratory, which demonstrates an homozygous deletion of chromosome 22. This, together with the analysis of additional MRT will be the basis for a positional cloning approach of the MRT tumor suppressor gene, including construction of cosmid contigs, search for transcription unit and screen for point mutations. Isolation of this new gene would enable to test its alteration in other tumor types characterized by alteration of chromosome 22 and should be important for the development of new diagnostic strategies for MRT. Training content (objective,benefit and expected impact) - Theoretical and practical training in oncogenesis - Positional cloning strategies - Analysis of gene alteration - Human cancer, pediatric tumors - Interaction between basic science and clinics Links with industry/industrial relevance(22) Development of diagnostic tools for small round cell tumors including Ewing tumor, neuroblastoma and MRT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quadratic refinements in algebraic geometry' in the context of a Horizon 2020 call.

assistant: **Objectives**

Enumerative geometry, the mathematics of counting numbers of solutions to geometric problems, and its modern descendents, Gromov-Witten theory, Donaldson-Thomas theory,   quantum cohomology and many other related fields,  analyze geometric problems by computing numerical invariants, such as intersection numbers or degrees of characteristic classes. This essentially algebraic approach has been successful mainly in the study of problems over the complex numbers and other algebraically closed fields. There has been progress in attacking enumerative problems over the real numbers; the methods are mainly non-algebraic.  Arithmetic content  underlying the numerical invariants is hidden when analyzed by these non-algebraic methods. Recent work by the PI and others has opened the door to a new, purely algebraic approach to enumerative geometry that recovers results in both the complex and real cases in one package and reveals this arithmetic content over arbitrary fields. Building on these new developments, the goals of this proposal are, firstly, to use motivic homotopy theory, algebraic geometry and symplectic geometry to develop new purely algebraic methods for handling enumerative problems over an arbitrary field, secondly, to apply these methods to central enumerative problems,  recovering and unifying known results over both C and R and thirdly, to use this new approach to reveal the hidden arithmetic nature of enumerative problems. In 2009 R. Pandharipande and I applied algebraic cobordism to prove the degree zero MNOP conjecture in Donaldson-Thomas theory. More recently, I have developed several aspects of the theory of quadratic invariants using motivic homotopy theory.


**Keywords:** enumerative geometry, quadratic forms, motivic homotopy theory, Gromov-Witten theory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Role of cell lineage in the generation of neuronal diversity in the mouse cerebral cortex' in the context of a Horizon 2020 call.

assistant: **Objectives**

Cell lineage is an important determinant in the generation of neuronal diversity. Understanding the relation between cell lineage and neuronal identity is critical to know where and when cell fate decisions take place during development.  In Drosophila, different neuronal types emerge from specific parts in the lineage tree. Some neuronal types specifically arise from certain branches (fate-restricted progenitor cells). Other neuronal types emerge from the same branch but at different times, following a temporal sequence. Whereas neuronal specification in mice seems to follow slightly different rules, the lack of appropriate tools to consistently target the same progenitor cells and following lineage progression with single-cell resolution has limited our understanding of this process. I thereby hypothesize that, similar to Drosophila, different neuronal types systematically emerge from dedicated parts of the lineage tree, although methodological limitations have impeded to prove this hypothesis. NEURORIGINS aims to fill this gap by producing tools to genetically target specific subsets of neuronal progenitors in the mouse cerebral cortex (Objective 1). To find fate-restricted neuronal progenitors and link these progenitors with specific types of projection neurons, I will use these tools to label and identify the neuronal progeny derived from these progenitor cells (Objective 2). In the last phase, I will follow the temporal progression of these sublineages, exploring whether some types of projection neurons are generated from the same sublineage over different developmental windows (Objective 3). Besides unveiling important insights on the developmental pathways resulting on neuronal diversity in the mouse brain, NEURORIGINS will provide me with a new set of technical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Comparative Genomics the Gene Expression of Clinical Strains of M.Tuberculosis' (1998-2002).

assistant: **Concept**

- Objectives To research the genome structure and differences in response to environmental stimuli of selected strains of M tuberculosis which differ in their clinical characteristics (standard laboratory strain H37Rv; a strain which has recently caused a major outbreak of tuberculosis in the UK and a strain from South India which has been shown to have a large number of genomic deletions). These strains will be compared in different terms: - Genomic comparisons: DNA will be extracted and compared firstly by DNA micro array analysis. This will reveal the identity and extent of any deletions in the two clinical isolates, compared to the reference strain, H37Rv. In order to investigate whether there are genes present in the clinical strains which are absent in the reference strain, we will use subtractive DNA hybridization and PCR. Subtracted DNAs will be directly inserted into cloning vectors, sequenced, and sequences novel to the clinical strains identified.- Infectivity and interactions with host cells: The strains will be compared for their ability to produce progressive infections in mice using a standard intravenous infection model and for their ability to infect and grow within both murine and human macrophages.- Comparison of gene expression: The transcriptional response of these strains following exposure to a range of environmental stresses will be investigated using the DNA M tuberculosis micro array. The gene expression analysis is performed by doing a competitive hybridization between cDNA prepared from the bacteria exposed To the stress and that prepared from the bacteria grown under conventional conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Distributed Dynamic Diversity Databases for Life' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

A coherent classification and species checklist of the world's plants, animals, fungi and microbes is fundamental for accessing information about biodiversity. The Catalogue of Life provides the world with a unique service: a dynamically updated global index of validated scientific names, synonyms and common names integrated within a single taxonomic hierarchy.<br/>The Catalogue of Life was initiated as a European Scientific Infrastructure under FP5 and has a distributed knowledge architecture. Its federated e-compendium of the world's organisms grows rapidly (now covering well over one million species), and has established a formidable user base, including major global biodiversity portals as well as national biodiversity resources and individual users worldwide.<br/>Joint Research Activities in this 4D4Life Project will establish the Catalogue of Life as a state of the art e-science facility based on an enhanced service-based distributed architecture. This will make it available for integration into analytical and synthetic distributed networks such as those developing in conservation, climate change, invasive species, molecular biodiversity and regulatory domains. User-driven enhancements in the presentation of distribution data and bio-data will be made.<br/>In its Networking Activities 4D4Life will strengthen the development of Global Species Databases that provide the core of the service, and extend the geographical reach of the programme beyond Europe by realizing a Multi-Hub Network integrating data from China, New Zealand, Australia, N. America and Brazil.<br/>Service Activities, the largest part of 4D4Life, will create new electronic taxonomy services, including synonymy server, taxon name-change, and download services, plus new educational and popular service
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multidimensional in vivo metabolic flux analyses: Resolving immune cells based on in vivo metabolic phenotypes' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The development of better immunotherapies is being hammered by our lack of understanding about immune cell metabolism in vivo at the sites of disease. We know that immune cell metabolism is pivotal in controlling immune function. For instance, disrupting Natural Killer cell metabolism prevents them from killing cancer cells. Cellular immunotherapies for diseases like solid cancer are underperforming and one central reason for this is the metabolic pressure exerted on immune cells in solid tumours. The core problem is that we cannot currently measure the metabolism of immune cells at the site of disease.  As a result, the biopharma industry is ill equipped to design immmunotherapies that are effective at these sites in the face of the metabolic stress.My ERC-CoG project (DC_Nutrient) has developed a new type of nutrient uptake assay with single cell resolution that can be used to probe metabolism in vivo. This is highly informative because the uptake of nutrients is the first limiting step for cellular metabolism. The core advance in our approach is to use bioorthogonal chemistry to attach a fluorophore to the nutrient after it has been transported into the cell. This bypasses all the pitfalls and failings of previous attempts to develop such assays using fluorophore tags. This PoC will advance this technology to simultaneously measure the uptake of 3 separate nutrients into immune cells at the site of disease, all with single cell resolution. Combined with an in vivo measurement of protein translation this will provide 4 dimensions of metabolic flux analysis for each cell analysed by multiparmetric flow cytometry. This innovative idea will provide a licensable assay technology that will be of high value to the biopharma industry as it will enable preclinical mouse studi