RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'PAssive Tracking of people and things for physical beHavior analysis' under Horizon 2020.

assistant: **Concept**

The main goal of passive tracking of people and things (PATH) is to define a new paradigm for physical behavior inference, where the dynamics of physical entities are tracked with minimal implementation cost, maximal privacy preservation, and intrinsically protected secrecy. PATH relies on the detection, tracking, and behavior analysis of targets without active devices, by integrating such capabilities in infrastructures for the Internet of things (IOT) that are already present in a monitored environment. This enables several applications including visitor counting and flow monitoring. The objectives of PATH are: (i) to develop a framework for system design and analysis, as well as to derive fundamental limits; (ii) to devise advanced techniques for detection and exploitation of networks of opportunity; (iii) to develop inference techniques based on wireless networks properties for intrinsically secure tracking; (iv) to recognize new patterns related to targets dynamics based on signal feature extraction; (v) to establish a proof-of-concept for an industrial-driven use case.PATH will enhance the potential of the experienced researcher (ER) by relying on: (i) the solid experience of the successful Ph.D. completed by the young ER, which included a year as a visiting student in the USA; (ii) a challenging, interdisciplinary, and multi-sectorial work program; (iii) a genuine mobility program with an outgoing phase at a top tier university, supervised by a world-renowned expert in the field, and with an incoming phase at a high ranked and growing research group; (iv) a secondment program at a leading industry in the field, which confirms the industrial interest and that is tailored to the ER, with an evident commitment in terms of supervision and infrastructures; (v) a rich,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Deciphering the fungus-host-microbiota interplay to improve the management of fungal infections' in the context of a Horizon 2020 call.

assistant: **Objectives**

Fungal infections have a major impact on human health, infecting about 2 billion people and killing more people each year than malaria or breast cancer. In particular, Candida species impose a high clinical and economic burden upon the European population. They frequently cause fatal hospital-acquired bloodstream infections. They also cause oral thrush and vaginitis. Most women have suffered an episode of vulvovaginal candidiasis, with ~8% enduring recurrent infections. The initiation and severity of a Candida infection depends on an intricate interplay between the infecting fungal strain and the individual’s immune status and microbiota, all of which can display significant variability. Therefore, for the first time, FunHoMic integrates experts in fungal pathogenesis, immunology, microbial ecology and ‘omics technologies to train 13 Early Stage Researchers (ESRs) who will define and exploit this Fungal-Host-Microbiota interplay to identify novel biomarkers (fungal or host genetic polymorphisms, microbiota profiles, metabolites or immune markers) for the stratification of a patient’s risk of serious fungal infection. This will pave the way for precision medicine in patient management through preventive or therapeutic interventions using antifungals, immune modulators or Live Biotherapeutic Products (LBPs). FunHoMic ESRs will gain broad interdisciplinary skills plus a translational mindset through our integrated, inter-sectoral training program. This will allow Europe to remain at the forefront of translational research in the field of medical mycology. To achieve this vision FunHoMic unites academic partners from France, Germany, The Netherlands, Switzerland, Spain and UK, a French Technology Research Institute with cutting-edge ‘omics technology platforms and three SME
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mapping inequalities through the life course' (MapIneq).

assistant: **Innovation**

The MapIneq project studies the trends and drivers of intergenerational, educational, labour market and health inequalities over the life course during the last decades. Our main driving research questions are:1. How do local and national opportunity structures enhance, suppress or mediate inequalities?2. How do changes and spillovers across the life domains and over life course contribute to inequalities?3. How are inequalities influenced by policies and societal shocks?Opportunity structures refer to social institutions, demographic and macroeconomic conditions and socio-environmental context, which we analyse across countries, regions and localities. We focus on societal changes influencing inequalities, including those related to family diversity and complexity, fertility, migration and population ageing, digitalization, the 2007-08 global financial crisis and how the covid-19 pandemic revealed and exacerbated inequalities.We compile a policy database of the educational, family, labour market, social benefits and tax-related policies, matched with subnational-level information on social and institutional structures and physical environments. This results in an easy-to-use, open access MapIneq product which consists of visualization and mapping tools, all underlying data, statistical programming tools, and open-access code. We link the information in the database to individual-level longitudinal and cross-country datasets to study the dynamic interplay between the spheres of life. This research is conducted under life-course stage specific work packages: Inequalities in the early childhood and families, Educational inequalities, Inequalities in school-to-work transitions, Unequal mid-career trajectories and Labour market exits. We consider how the covered societal ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Eifac symposium on inland fisheries management and the aquatic environment, windermere, united kingdom, 12 - 15 june 2002' (1998-2002).

assistant: **Innovation**

The proposal submitted for EC funding aims at covering travel costs and subsistence allowance for participants from Eastern Europe who will present papers and/or posters at the EIFAC Symposium on Inland Fisheries Management and the Aquatic Environment . The Symposium is organized by the Food and Agriculture Organization of the United Eastern Europe to exchange knowledge among countries and to present, in reviews, an appraisal of fisheries management activities and their impact on the environment, constraints on their application, issues and options regarding their utilization, and the benefits and problems associated with these activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Innovative combination therapy against bladder cancer', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The objective of this project is to lay foundation for the continued clinical development and commercialisation of MFA-370, a novel medication against Bladder Cancer (BC).BC is the ninth most common cancer worldwide. In Europe, more than 175,000 people are diagnosed with BC in Europe each year, and this number is increasing, especially among women. Compared to other major cancer types, the relative five-year survival rate in BC has remained unchanged for the past 20 years. The implications are clear: the development of new therapies targeting BC is thus warranted and in great demand among clinicians and BC patients. The established treatments are highly aggressive, leading to major side-effects and reduction in QoL among patients. Recognizing large unmet clinical need, Ectin has developed a novel combination BC therapy consisting of a well-defined ratio of two commonly utilized pharmaceuticals with expired patents. In the pre-clinical studies, MFA-370 has shown to be able to induce cancer cell death without the addition of any chemotherapeutic or radiotherapeutic agent. This offers a new hope to BC patients. The pre-clinical evaluation of this medication is completed, enabling continued development process.In the Phase 1 project, we will develop a business plan that will guide the future clinical studies and exploitation efforts (to be pursued in the Phase 2 project). The assumed commercialisation strategy is to take the product to the Phase I/IIa level and thereafter acquire strategic partner for continued clinical studies and market launch.Fighting BC is an EU-wide challenge, as it is one of the most expensive malignancies to treat and affects all genders and age groups. At the same time, research targeting the disease is greatly underfunded in the EU and internationa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Rethinking Exchange: An Historical Inquiry into Self-love, Speech and Sociability' (RETHEX), addressing dissemination and exploitation.

assistant: **Impact**

The recent lockdown brought the commercial interaction of everyday life to a stop for most people in the world at almost the same time. This resulted in a general isolation that highlighted the extraordinary relevance of economic exchanges, also from a social and existential perspective. This experience showed how unfounded it is to think that exchange is just a matter of self-interest, as is believed both by those who criticize commerce for destroying social bonds and traditional ethical systems, and those who, on the contrary, unconditionally defend the market economy. This reduction of exchange to a matter of self-interest was not present in the formative stage of political economy when, in the late 18th century, the conceptualization of commerce was bound up with discussion on the origin of human society, and a richer connection between exchange, speech and sociability was conceived. It is thus a task of the utmost importance to rethink economic exchange today by reconsidering in their historical and theoretical depth the multidisciplinary debates on human nature, on the origin of sociability and of language. To this end, the project will be organised around three major axes associated with the following controversies: a) self-love and exchange in the debate on human nature; b) sociability, values and exchange in the debate on primitive societies; c) speech and exchange in the debate on the origin of language. The project will explore the connections between these different disputes which originated in Europe in the 17th century in the nascent disciplines of anthropology, linguistics, economic science. An interdisciplinary perspective will be adopted, combining the different kinds of sources ranging over time from the Essays of Montaigne to the works of Adam Smith.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Aortic Valve Replacement using Individualised Regenerative Allografts: Bridging the Therapeutic Gap' (ARISE), addressing dissemination and exploitation.

assistant: **Impact**

65,000 aortic valve replacements (AVR) are performed in Europe each year to treat acquired and congenital aortic valve diseases. In affected patients, mortality without AVR is extremely high and 50 % die within 2 years. Current AVR options are, however, limited for young patients - especially female patients - and those unwilling to accept life-long medical anticoagulation with its inherent risks. None of the currently available prostheses for AVR is tailored toward the individual patient or allows for individual regeneration. The ARISE project will bridge this therapeutic gap in a Phase II clinical study to determine the feasibility, safety and efficacy of regenerative heart valves for aortic valve replacement. After extensive preclinical work, Haverich et al. have used decellularized allogenic heart valve matrices for AVR on the basis of compassionate use in 34 patients with tentative assessment showing auspicious initial clinical results. However, transferring this regenerative approach to routine clinical application necessitates controlled prospective clinical trials which are lacking to date. The translation of research in regenerative medicine from bench to bedside is frequently hampered by lengthy and complex regulatory procedures. This holds especially true for regenerative solutions based on human cell or tissue products where regulatory paths at national level are often unclear. Making these products available across Europe adds a further level of complexity as regenerative products are not subject to harmonized procedures, such as those for pharmaceutical products within Europe. The ARISE  consortium will address these challenges, integrating a network of six leading centres for cardio-thoracic surgery, each with proven track records in clinical research, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'OCeanic and South East Asian Navigators.' (OCSEAN).

assistant: **Innovation**

This proposal unites researchers from Canada, Europe, Island Southeast Asia and Oceania to re-evaluate our understanding of the Austronesian expansion. It does so using new high-density data from archaeology, biological anthropology, linguistics and genetics, and aims to unite them within a common statistical framework. OCSEAN achieves a true synthesis of disciplines using state-of-the-art computational and statistical methods to interrogate the structural relationship between joint data sets. The research contextualizes the expansion of the Austronesian language family within the growing evidence for social and political complexity across Island Southeast Asia and coastal mainland regions prior to the arrival of rice and millet agriculture to Taiwan during the mid 5th millennium BP. It also takes into account the rich history of interaction since the spread of the Malayo-Polynesian branch of Austronesian outside of Taiwan. OCSEAN brings together leading researchers from the humanities and sciences and combines the resources of multiple laboratories to tackle questions that can only be addressed with this extensive network of cooperation. We will embrace the complexities of the archaeological, genetic and linguistic records, providing an alternative to directional, progressive and technological deterministic models, whilst recognizing the difficulties inherent in identifying concepts of culture or ethnicity with archaeological evidence, because of the very fluidity of these constructs. Through our combined expertise, we will demonstrate that a new way of working with big data leads to new insights at the small scale. In doing so, it will fundamentally change the way people do research.


**Keywords:** Linguistics, Human, Structure, Southeast Asia, New Guinea, Melanesia,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel activity-based proteome and lipidome profiling of Arabidopsis in response to a changing environment: An opportunity to identify new key players in plant lipid metabolism' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

LIPIDQUEST is based on new cutting edge developments in the area of proteomics and mass spectrometry and focuses on identifying new key players in lipid biology in the model plant Arabidopsis thaliana. Short term output will advance our understanding of lipid biosynthesis and turnover and has the potential to contribute to medical applications; ultimately, such research will increase the world’s chances to become less dependent on fossil fuels and thus fight the threatening energy crisis as well as climate change. 3 different approaches have been chosen to deliver new gene candidates combining uniquely Dr. Kelly`s skills in the area of storage and membrane lipids in higher plants, Associate Prof Wenk’s multidisciplinary approaches using lipidomics as well as Prof Feussner’s proficiency in lipidomics and plant lipid biochemistry: 1- A novel screen based on protein-lipid interactions is targeted at capturing lipases and other lipid-binding proteins by a combination of proteomics and subsequent mass spectrometry. 2- Alternatively, a suppressor screen of a mutant impaired in ß-oxidation will identify key components between membrane lipid degradation and ß-oxidation. 3- In a forward genetic approach state-of the art lipidomics will be performed on a selected subset of Arabidopsis mutants and on the large genetic pool of intercrossed Arabidopsis accessions which will be exploited to reveal the genetic grounds for functional differences in the lipidome in response to a changing environment. This project will add to the European expertise within state-of the art lipidomics and applied plant biology and will establish the grounds for long lasting collaborations between the University of Göttingen and the National University of Singapore. In addition, it will allow Dr. Kelly to s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'The mechanism of groel assisted protein (un) folding'.

assistant: **Concept**

In the cell, the folding of proteins is facilitated by the presence of molecular chaperones. Chaperones appear to increase the yield of native proteins by protecting the polypeptide chains from aggregating during the folding process, and possibly by correcting misfolded structures. One of these chaperones is the GroEL chaperonin. GroEL function requires large conformational changes, which are induced by the binding of ATP and the co-chaperonin GroES. It remains unclear how ATP triggers these conformational changes and how these changes induce the (un) folding of proteins. We propose to elucidate two essential aspects of the GroEL cycle by several approaches based on molecular dynamics (MD) simulations. Our first objective is to show how ATP binding and hydrolysis induce the observed conformational transitions in GroEL. Hereto, we will perform MD free energy simulations to obtain the free energy differences among the structures involved, and employ a free energy component analysis to identify the key interactions. Our second objective is to examine if and how GroEL actively unfolds misfolded proteins. Hereto, we will drive" the conformational transition of GroEL by applying an external force to simulate the changes in the time domain accessible to MD simulations. During the transition, the denatured protein will be simulated and extensively sampled We will track the unfolding process and determine the origin of the unfolding force by a detailed analysis of the protein substrate structures and from its interactions with GroEL."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Commercialization of a novel method for fabricating cheap tailor–made superhydrophobic surfaces' (HYDROPHO-CHEAP), addressing dissemination and exploitation.

assistant: **Impact**

The aim of the HYDROPHO-CHEAP project is to optimize, protect, and commercialize a recently developed methodology that allowed us to achieve “tailor-made” control of the wettability of polymer surfaces, rendering them super water-repellent. What makes our methodology highly innovative is the fast and cheap fabrication process, and most importantly the potential of implementing it in real-life environments. With this unique method we can fabricate ‘superhydrophobic islands’ (with a spatial resolution of 100 μm in the horizontal plane) of any shape i.e. dots, stripes, polygons and interconnected shapes, in any combination. Such functional surfaces can be produced in a single and fast fabrication step, without applying any hydrophobization top coating since we process an inherently hydrophobic material.We plan to demonstrate the capabilities that our method can offer to specific applications (microfluidic chips, fog harvesting, low flow friction surfaces) that we identified as the most prominent, protect the intellectual property that we have produced through our research and to find the optimum route-to-market in order to commercialize our research results.