RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tissue-engineering the tumour microenvironment to improve treatment of pancreatic cancer' (CHIPIN).

assistant: **Concept**

My vision is to address a clinical problem with a novel and transformative approach. Using my unique expertise in cell biology, tissue engineering and translational research I will design technology platforms to test new treatments for human pancreatic cancer.Pancreatic tumours are cancers of unmet medical need with 85% of patients dying within 9 months of diagnosis. To find better therapies, we need patient-specific models that mimic the biology of tumour tissues and target interactions between malignant and non-malignant cells. Biomimetic tissue engineering is a powerful approach to generate 3D cancer models, however, only a few scientists use these technologies. Most 3D cultures of human cells include reconstituted matrices that originate from murine tumours containing undefined amounts of extracellular matrix and growth factors. There is no tissue-engineered 3D model that allows control over patient-specific and biomechanical characteristics of the pancreatic tumour microenvironment.I hypothesise that 3D approaches that replicate the native tissue composition and biomechanical properties will behave like real tumours to provide clinically predictive platforms and to test novel treatments that target both malignant and non-malignant cells.To test my hypothesis, I will:•3D-print matrix and cellular elements of the microenvironment of human pancreatic tumours•Develop a cancer-on-a-chip model of liver metastasis•Compare the crosstalk of malignant and other microenvironment components with the human disease•Validate my new platforms with treatments in clinical trials and test novel combination treatments that slow down or reduce tumour growth.In a multidisciplinary project, I will use:•3D printing to build platforms composed of hydrogels, fibrous scaffolds and patient-de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Adaptive Reconfigurable Access and Generic interfaces for Optimisation in Radio Networks' (ARAGORN).

assistant: **Concept**

The primary aim of the ARAGORN project is to research and develop a Cognitive Resource Manager (CRM) that aims to ensure that efficient use is made of both node-local and shared resources in a collaborative wireless system. These include, for example, local energy consumption and shared use of available bandwidth. In order to achieve this, ARAGORN will develop a range of standardised interfaces, using which the CRM will be able both to obtain information from and to update the configuration of each layer of the protocol stack, including at the application layer. Given this, the CRM will seek to optimise cross-layer and inter-node performance using multi-dimensional optimisation algorithms provided by partners from the machine learning and artificial intelligence communities. The proposed approaches have been selected because of the need to synthesise a relatively low-dimensional response from the many potential dimensions that could affect the optimal, all in the presence of incomplete and out-of-date information.In contrast to other cognitive radio research, the ARAGORN project does not focus on dynamic spectrum access networks but aims to add real cognition to mobile devices, enabling them to take reasonable decisions autonomously.The main expected outcomes of the project are a solid basis of theoretical and architectural work for next generation cognitive radios and networks and a working prototype implementation. The prototype will apply the techniques developed and prove their practical feasibility working in one of the ISM frequency-bands. As key components of ARAGORN, exploitable interfaces and the Cognitive Resource Manager Framework will be implemented.The high quality consortium possesses a unique combination of expertise from across the wireless, software and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Construction of computational logics ii' in the context of a Fourth Framework call.

assistant: **Objectives**

CCL II aims at combining constraints with other computational logics (with applications in automated deduction and declarative programming), at designing new constraint solving techniques, and at designing combination techniques for various logics among equational logic ( or algebraic rewriting), Horn clause logic, lambda calculli.Combining programming paradigms carries an important potential for applications both in industry and in academia. The choice of a paradigm for a given problem often determines the success or failure of the application.The expected results of the Working Group are:- increased communications and co-operation among all the researchers concerned with combining programming paradigms,- information dissemination of reports and publications: through an Internet FTP server and WWW page to be maintained by DFKI- implementations of new public-domain prototypes,- extensions of the existing software (BABEL, Oz, SATURATE,....) as well as commercial software packages such as CHIP.The partners are involved in several different national and international projects (e.g. Esprit Project 8402 DAYSY) and working groups such as CONSOLE Network (HCM. Most of the projects aim at developing or studying some computational logic. The CCL working group is concerned with their combination and is therefore complementary to the other activities.CCL II will organise four workshops and a summer school. The workshops will take place at Madrid (E) (September 9-11,1996), Dagstuhl (D) (Fall 1997), Lille (F)or Frankfurt (D) or Jerusalem (Isr) (Fall 1998° and Orsay (F° (Summer 1999).The workshops will bring together CCL members with other researchers on invitation. The last workshop will be open to non-CCL members.A summer school will be organised at Orsay, in conjunction with the l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Combating Poverty in Europe: Re-organising Active Inclusion through Participatory and Integrated Modes of Multilevel Governance' (COPE).

assistant: **Concept**

To combat poverty, European strategies propose implementing active inclusion policies. However, these policies face serious conceptual questions and governance challenges. Practical implementation is problematic in that social exclusion is a multidimensional problem that goes far beyond financial poverty, necessitating the participatory co-production of individual opportunities. In addition, the complex social needs of the most excluded groups require the integration of different policy fields and the involvement of beneficiaries, civil society and public agencies in the co-production of welfare. This project focuses on the political and organisational challenges of this complex governance model which has evolved from European, national and local policies. Investigating the co-production of active inclusion in a multilevel, multidimensional and multi-stakeholder perspective addresses key questions: How can the combat against poverty be organised in practice? How do European, national and local institutions shape the co-production of active inclusion? How do beneficiaries participate in these policies and how does this shape their life courses?Project COPE integrates multiple disciplines and experienced social policy researchers. A common theoretical and methodological approach guides the research in each work package. First, we will contextualise poverty as a multidimensional challenge. Secondly, COPE will study how minimum income schemes for three different groups (lone mothers, long-term unemployed, working poor) are organised in five EU countries (Italy, Germany, Poland, Sweden and the UK) and how they cope with multilevel and multi-stakeholder modes of co-producing active inclusion policies. As these countries cover different welfare regimes, the results will have d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Tuning the electronic structure of two-dimensional semiconductor junctions' (2D-InTune).

assistant: **Innovation**

Lateral junctions between two-dimensional (2D) semiconductors are conceptually the smallest possible electronic devices. This project investigates the basic physics of these systems as the type of band alignment, the band bending and depletion region, which are decisive parameters for any application. Semiconductor junctions composed of 2D transition metal dichalcogenides (TMDs) will be prepared on hexagonal boron nitride (hBN) or graphene (Gr) on Ir(111). The use of the single-crystalline metal substrate allows the application of surface science methods for preparation and characterization, while the ultrathin buffer layer leaves the intrinsic properties of TMDs undisturbed. Intercalation of guest atoms between the buffer layer and Ir will be used as an elegant and non-invasive method for doping the TMDs. This will also tune intrinsic band bending at the 1D-interface of the TMD junctions, which is yet to be explored for various 2D systems. To separate the effect of inhomogeneous doping and inhomogeneous structure, two types of lateral TMD junctions will be prepared: Homojunctions will be achieved by doping only one part of the TMD island by extending it over the interface of intercalated patches in hBN. Heterojunctions will be composed of two different TMD materials grown on homogeneous vdW substrate, either fully intercalated or pristine. Samples will be prepared by combining two TMDs (ReS2 and WS2) and two dopants (n and p). Scanning tunneling spectroscopy (STS) and Kelvin probe force microscopy (KPFM) will be used for the characterization of the 1D-interfaces and the reconstruction of the band diagrams. Dielectric screening induced by the substrate will be analyzed by comparing values of the band gaps and shifts of critical energy points between different systems. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Placental uptake and transfer of environmental chemicals relating to allergy in childhood years'.

assistant: **Objectives**

Increasing pollution and contamination of the environment with xenobiotics may be linked to the increasing prevalence of allergic diseases throughout Europe. The hypothesis addressed by this proposal is that maternal environmental exposure to xenobiotics during pregnancy triggers intrauterine sensitisation and modulation of placental enzyme and immune function. Resulting unbalanced cytokine production will affect the immunoregulation of the placenta and may initiate an allergic reaction following further exposure in childhood resulting in higher levels of clinical allergy in children postnatal. Extent of placental transfer and fatal uptake of xenobiotics will be measured directly with a human perused placenta model and these data will be correlated with epidemiological information on the development of allergy in maternally exposed children.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Particle Training Network for European Radiotherapy' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

A Particle Training Network for European Radiotherapy (PARTNER) will be established in response to the critical need for reinforcing research in ion therapy and the training of professionals in the rapidly emerging field of hadron therapy. This is an interdisciplinary, multinational initiative, which has the primary goal of training researchers who will help to improve the overall efficiency of ion therapy in cancer treatment, and promote clinical, biological and technical developments at a pan-European level, for the benefit of all European inhabitants. This need has particular urgency since two particle therapy facilities will soon become operational in Heidelberg (HIT, Germany) in early 2008, and in Pavia (CNAO, Italy) later in 2008. These are the first dual particle therapy centres to be built in Europe but others have been recently approved in Austria, France, and Germany, and there are longer-term plans for advanced accelerator systems in Spain and UK. PARTNER brings together ten academic institutes and research centres of excellence, the two leading European companies in particle therapy, IBA and Siemens, and a recently established SME enterprise specialised in the area of radiation treatment planning solutions. All partners are known world-wide in the diverse but complementary fields associated with particle therapy: clinical, radiobiological and technological. Thus the network covers a unique set of competencies, expertise, infrastructures and training possibilities. The ultimate goal of hadron therapy is to deliver more effective treatment to the cancer patient. Potentially hadron therapy can have a very major impact on health of citizens. The context of a new technique and a dynamic research program in an area of great societal demand offers outstanding train
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Silent Air Flows in transport, buildings and power generation' under Seventh Framework.

assistant: **Concept**

The FlowAirS proposal is collaborative training research network. It will be focused on the generation, propagation and reduction of sound in flow ducts for transport, buildings and power generation. There is a real need for a European-wide training in this field: the FlowAirS general objective is to train by research a new generation of young researchers with multi-disciplinary skills and able to make research careers more attractive and will enhance their own career opportunities.To achieve this goal, a partnership has been established between seven academic research centres of excellence, five industrial world leaders in their respective sectors, one innovative SME and four private research institutes or consulting engineering company: the collaboration between academia and private sector representatives is a key element of the FlowAirs training research programme. The work programme is divided in 8 Work Packages (WPs). The first 2 WPs deal with sound sources mechanisms. WP3 will be focused on innovative solutions for noise reduction.Three other WPs are concerned by the different numerical procedures and system identifications that are used in flow duct systems. One of the WP deals with the dissemination of the results to European citizens, researchers and industries. The last WP is on management and training. Training activities will be organized along three main axes: 1) training through research; 2)formal training giving all the important skills needed by researchers in the field of sound in flow duct systems and 3)training through practical experience on industrial sites. By participating to FlowAirS young researchers will gain a multi-disciplinary and appropriate background in generation, propagation andreduction of sound in flow ducts. The FlowAirS project will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Deep Learning Powered Holographic Microscopy for Biothreat Detection on Field' in the context of a Horizon 2020 call.

assistant: **Objectives**

HoloZcan brings a new tool for security actors (police, relief workers, disaster managers, crisis managers, stakeholders responsible for public safety, critical infrastructure, and service providers) notably in the fields of autonomous detection and response capabilities.The project will increase (environmental and exhaled) bio-aerosol sensing/measurement capability of CBRN practitioners by developing a high resolution, large throughput, automatic and highly portable detection system for making automatic classification of pathogens and particles. HoloZcan develops of a novel holographic microscopy and imaging technology for rapid and cost-efficient screening of potential biological threats and unknown, potentially dangerous substances, combined with methods of artificial intelligence and machine learning. It establishes a framework of a dynamic feature selection and validation algorithm to support the continuous innovation capability of the system in the field of adaptive learning and database optimization for specific bioinformatic applications. The project also develops comprehensive and innovative means of respiratory, ventilation and environmental biological data sampling that can be used in real-time, standoff or in mobile bio-detection context. The project indicates the HoloZcan technique versatility for a wide range of applications and demonstrates its technical feasibility. The project responses to the actual needs of European practitioners and technological gaps identified by the ENCIRCLE project as indicated in the ENCIRCLE Catalogue of Technologies and addresses several shortcomings of the current approaches to bio-threat agent detection. The HoloZcan project applies a flexible adaptive approach to design and CBRN practitioners are engaged as project partners
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integration of two-component ceramic injection moulding for large-scale production of novel multifunctional ceramic components for automotive and railway applications' (CARCIM).

assistant: **Concept**

The main goal of the project is the integration of the two-component ceramic injection moulding (2C-CIM) as a low cost and large series production technique for development of complex shaped ceramic components for automotive and railway applications offering a high degree of structural and functional integrity. The 2C-CIM technology which is known from two-coloured plastic parts shall be qualified for the production of advanced ceramic components combining two ceramic materials with different or opposite properties without additional joining steps. This manufacturing process will allow the production of components with complex geometries within tight tolerances and short processing times. By combining different materials properties, like electrical conductivity and electrical isolation, or high mechanical strength and high friction coefficient, novel components with a high degree of functionality and longer life cycles can be provided by this shaping technique. The 2C-CIM technology shall be developed as a high pressure and a low pressure variant for ensuring highest flexibility of production. Moreover, appropriate characterizing methods will be applied which will enable the producer to detect defects in co-injected components even in the green state which is a key factor for a highly efficient production technique. Non-destructive methods of characterization will help to reduce scrap-rate remarkably and to prevent loops in the production cycle. The project tasks will be solved by involving simulation tools covering the complete production process, tailoring of ceramic feedstock properties considering simultaneous shrinking behaviour during debinding and co-sintering and implementing multifunctional ceramic parts into prototype systems for automotive and railway applica