RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'CiRcular Economy: SusTainability Implications and guidING progress', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

CRESTING will train Early Stage Researchers (ESR) in cutting edge systematic analysis of the process of transformation to a Circular Economy (CE). Establishing a CE (such that the maximum value is extracted from materials and waste generation minimised) is a major policy area within the European Union and elsewhere.  Explicitly seen as increasing economic competitiveness and laying a foundation for environmental employment, CE policies are designed to increase resource efficiency and decrease carbon dependency. Previous and ongoing research into the CE, however, has been largely concerned with strategies for implementation.  The many different fields of activity comprising the CE (e.g., re-use, recovery, recycling, eco-design amongst others)    operate with varying degrees of effectiveness in different places and for different materials.  These fields of activity have not been critically analysed as an interrelated social, technical, environmental and, significantly, spatial phenomenon.  This programme will advance the critical analysis of the concept and sustainability implications of the CE by the training of 15 ESR analysing CE-related activity and initiatives in a range of geographic and economic settings.  CRESTING is divided between 5 work packages (WP) analysing: current discourse and policy contexts (WP1); corporate engagement with the CE (WP2); public sector engagement in the CE (WP3); the potential for local economic development and employment from the CE (WP4); and measuring life cycle impacts and developing sustainability indicators relevant to the CE (WP5).  With multidisciplinary and international supervisory teams including non-academic partners within each WP, CRESTING will 1) analyse the sustainability implications of the CE; 2) analyse the spatial dime
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Speech Driven Interfaces for Consumer Applications' (SPEECON).

assistant: **Innovation**

The project promotes the integration of speech recognition technology into consumer devices for many languages and acoustic environments. Examples of such devices are mobile telephones, TV-control sets and car navigation kits. The transfer of the speech driven interfaces from one to various other languages and different acoustic environments is accomplished via language and application specific speech databases, which are used to train the acoustic models of the recognisers. Speech databases covering 18 languages and typical acoustic environments of the application areas are developed. Due to the diversity of acoustic environments, the speech databases alone cannot cover all these conditions sufficiently. In order to avoid degradation in recognition performance, therefore, methods are investigated which allow the adaptation of the speech databases to the specific acoustic environment in which the device is used.Objectives:The overall goal of SPEECON is to enable the project partners to transfer their speech recognition technology to interfaces for consumer devices such as mobile telephones, TV-control and home appliances, for many languages and acoustic environments. For transferring the recognisers, a set of speech databases will be created covering 18 languages and different acoustic environments as found at home, office and public places. In order to broaden the range of applications, specific speech database adaptation techniques are developed. The feasibility of the transfer approach is shown by three demonstrators.Work description:An analysis of the market for voice driven consumer devices will be made which will lead to the requirements for the functionality of the recognisers needed for market relevant applications. These requirements determine the specification
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of multifunctional nanometallic particles using a new process - sonoelectrochemistry' (SELECTNANO).

assistant: **Concept**

Metals and moreover nanometallic particles will play a major role in the sustainable growth of European industries such as: chemical, automotive, pharmaceutical, etc. This due to the fact that they offer improved properties in comparison to bulk materials in use. Modernization and leadership in European heavy industry would require development of new nanometallic multifunctional powders with dedicated characteristics. Their development and production will be based on unique innovative methods. SELECTNANO in tends to manufacture new metal and transition metal nanoparticles for dedicated new applications, using the novel process, namely - SONOELECTROCHEMISTRY. Sonoelectrochemistry is a new emerging technology .This technique combines electrolysis and sonolysis. The sonication horn serves as a cathode for the electrolysis process and as a transducer releasing US (Ultrasonic) waves. Short electric pulses, which reduce ionic species and deposit the mechanic nanoparticles on the cathode are followed by US pulses cau sing the nanoparticles to fall to the bottom of the cell. Scientific and technological Objectives: 1.Application of Sonoelectrochemistry for synthesis of multifunctional nanometallic particles 2.Development of new technologies for stabilization of nanome tallic particles in different matrices 3.Processes scale up 4.New industrial applications - 4.1Use of metallic nanoparticles for security issues such as: detection and authentication of articles by printing conductive labels and coding of information ba sed on a printed pattern. 4.2Nanostructured metallic coating by Cold Gas Dynamic Spray deposition 4.3Development micron and submicron sized shell structures for release of encapsulated active materials 4.4Adaptation of the new developments into: High in tensity col
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'How iron and manganese affect the central metabolism in pathogenic mycobacteria' under Horizon 2020.

assistant: **Concept**

I aim to define how Mycobacterium tuberculosis (Mtb) and Mycobacterium abscessus (Mabs) have adapted their central metabolism (CM) to variation of metals availability. Bacterial nutrition is a fundamental aspect of pathogenesis. While the host environment is in principle nutrient-rich, hosts have evolved strategies to interfere with nutrient-acquisition by pathogens. Pathogens, in turn, have developed mechanisms to circumvent these restrictions. The ability to adapt to nutrient availability drives the fitness of pathogen, influencing the outcome of infection. One of the strategies adopted by innate immune cells such as macrophages and neutrophils to limit bacterial replication is varying the availability of metals, starving or intoxicating the unwelcome guest.The expression and the activity of some central metabolism enzymes are regulated by metal availability in pathogenic bacteria, and it is unknown how this regulation affects the assimilation of carbon sources. Preliminary data shows that Fe and Mn affect the carbon sources metabolism in these pathogens. I aim to identify potential Fe or Mn-regulated metabolic routes utilising proteomics (LC-MS/MS) and metabolomics (LC-MS). These investigations will help to elucidate a neglected aspect of mycobacterial physiology, the interaction between metal homeostasis and central metabolism, disclosing more mechanisms underlying the mycobacteria physiology. Through this EF, I will bring the knowledge acquired during my five-year appointment at the Francis Crick Institute (UK) (mycobacterial metabolism and metabolomics) to my origin country (Italy) implementing my research line at the University of Padua. Through this EF, I will undertake training to re-enforce my independence, increase my expertise in proteomics (at the UNIPD) an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Export Restriction Free Travelling wave tubes Materials' in the context of a Horizon 2020 call.

assistant: **Objectives**

The ERFTM project aims to develop new European manufacturing processes for preparing material components of power amplifiers based on Travelling Wave Tubes for space and ground applications using raw materials not governed by Export Restriction comprising an helix made with flat ribbon maintained by ceramic support rods.The studies will advance work from TRL3 to TRL6, in compliance with the non-dependence action “U7-Power Amplification Travelling Wave Tube (TWT) materials” as described in the revised Joint Task Force (European Commission-ESA-EDA) draft document of the Critical Space Technologies for European Strategic Non-Dependence Actions for 2015/2017.  The main applications of these power amplifiers are space satellites and ground applications such as telecommunications.The ERFTM project will specify, develop, test and qualify the export restriction free helix wire materials on the one hand and the export restriction free dielectric materials for helix support rods on the other hand. Both will be subjected to a complete qualification process for space tubes and terrestrial communication tubes, as well as a commercial evaluation of the technologies involved.The ERFTM consortium includes 2 European large enterprises from the Thales Group, worldwide leaders in space TWT development and production, 1 industrial company and 2 SMEs. The latter 3 companies are innovative technology providers not yet involved in the space domain. In addition, 1 research laboratory with metallurgy and characterization expertise is a full partner. These partners are present in 3 European member-states, and join their expertise to successfully tackle the formidable challenges of the ERFTM project. Given its focus on developing materials to avoid export restrictions imposed by certain non-Europ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DNA-Based Modular Nanorobotics' in the context of a Horizon 2020 call.

assistant: **Objectives**

Robotic systems essentially comprise sensors and actuators connected to and coordinated by an information-processing unit. These principles apply to the human scale robotic systems that currently transform the way we work and live. With DNA-Based Modular Robotics (DNA-Robotics) we will take the first steps to scale advanced robotic behavior to the molecular scale for future medical and technological applications. DNA-Robotics brings together the leading research groups in DNA nanotechnology in Europe to collectively develop an integrated and modular robotic platform and demonstrate applications of the novel technology. DNA-based construction is a natural modular platform, which via the programmability of sequence design and self-assembly allows different structural and functional motifs to be flexibly combined. DNA modules will be developed with a range of novel functions for sensing, actuation and intra-system communication and computing, implementing all of the typical components required for a robotic system at the molecular level. Our overall goal is the creation of the first “industry standard” for modular robotics by the establishment of a modular “plug-and-play” platform that allows the construction of custom-made nanorobots for advanced applications in research and industry. The ESRs will be trained in and develop functional modules that in close collaboration among the ESRs and Partners will be assembled to advanced molecular robots. The highly interdisciplinary research and training program will exploit the synergy between the different competences of the Partners. The innovative and applied focus is supported by the involvement of the company ATDBio as Beneficiary and five companies as Partner Organization that will also provide complementary skills training
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Neural apoptosis: developmental significance and molecular mechanisms' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The death of cells by apoptosis is a normal, but still poorly understood process in the developing nervous system. Apoptosis can affect some neurons already at the time of their last mitosis, or later, when their axons reach the target cells. Defined groups of premigratory neural crest cells also die, for example in rhombomeres 3 and 5 of the hindbrain. This early death might serve the purpose of patterning crest cells before migration. In the present proposal, early apoptosis will be studied in the retina and in the hindbrain, together with the growth factors that appear to regulate cells death. Recent results indicate that brain-derived neurotrophic factor controls the survival of retinal cells very early during the formation of the retina, whereas bone morphogenetic protein 4 induces the death of crest cells. We will study the developmental patterns of expression of these factors and of their receptors and correlate these with areas where apoptosis can be observed. Chick embryos, as well as cultured cells, will be treated with growth factors, with agents blocking their action, and with specific inhibitors of cell death, including protease inhibitors. The resulting anatomical alterations will be examined in order to gain insight into the physiological meaning of cell death. The role of the neurotrophin receptor p75 as a regulator of early cell death will also be examined, especially with regard to its ability to participate in signal transduction. Recent results indicate that its intracellular domain binds cytoplasmic proteins, including one that contains zinc finger motifs (named neurotrophin receptor interacting factor", NRIF). The generation of nrif (-1-) mice will help to understand the function of the p75 receptor and its role in the regulation of apoptosis."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated control strategies for improving energy management and comfortin new and existing buildings' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

OBJECTIVES OF THE PROJECT To develop a generic framework for integrating control strategies in order to improve energy management as well as indoor comfort in non-domestic buildings To develop a set of smart control schemes compatible with this generic framework. To develop prototypes of controllers using this integrated approach To validate the advantages of this approach in simulation and to prepare for a future demonstration in occupied buildings. TECHNICAL APPROACH A generic approach will be developed for describing the methodologies for integrating the wide variety of controlled systems found in buildings. A number of common functionalities will be defined for issues including the coordination of control strategies, conflict resolution, demand estimation and capacity limiting. Specific strategy modules will be developed at the services, plant and zonal levels of a building. A set of exemplar systems will be chosen to represent a range of different challenges and complexities in systems integration. The generic framework will be used to develop the three major supervisory levels in which aspects specific to the different control levels are embedded. The development of these modules will be performed in two phases: the first phase will concentrate on methods for integrating current state-of-the-art controls, this is aimed at near-market application in existing buildings; the second phase will expand the methods to encompass information available from future systems where techniques such as advanced fault detection will be in operation. Testing will initially be performed using simulation of both the individual level controllers and a fully integrated controller. Further testing will be performed in emulation, this involves connecting the controller hardware through s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular characterization and targeted elimination of metastatic pancreatic cancer stem cells' in the context of a Seventh Framework call.

assistant: **Objectives**

Pancreatic adenocarcinoma is the deadliest solid cancer and currently the fourth most frequent cause for cancer related deaths. Over the past decades, there has hardly been any substantial therapeutic progress regarding clinical endpoints. New hope has now been generated by the re-emerging cancer stem cell (CSC) concept. We have identified and characterized pancreatic CSC in the context of tumour growth, metastasis, and resistance to chemotherapy. To eventually be able to develop a targeted therapy for eliminating CSCs as the root of the tumour, we will perform comparative functional and genomic analyses of the identified, highly purified human CSC populations, their more differentiated progenies, normal tissue resident stem cells, and hematopoietic stem cells. For these analyses, we are also focusing on their demonstrated resistance of CSC to chemotherapy as well as their invasive properties and tumour-initiating capacity as demonstrated in our orthotopic mouse models. Subsequent functional characterization of newly identified genes regarding their biological function for tumour angiogenesis, invasiveness, and metastasis will be carried out. Moreover, it is similarly important to investigate in parallel the origin of CSCs, which may aid us to develop new therapeutic strategies to prevent transformation of tissue-resident stem cells. The role of risk factors that have been associated with the development of pancreatic cancer, namely smoking and chronic pancreatitis will be investigated in this context. Together, the above experiments will generate important clues how CSCs circumvent the physiological regulatory elements of stem cell functionality and, even more importantly, how these cells escape the response to standard cancer therapy. Eventually, these new insights ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Clinical validation of a serum protein biomarker signature for the early diagnosis of pancreatic cancer.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The IMMPACT project aims to perform the clinical validation of a serum biomarker signature for the early diagnosis of pancreatic cancer. The biomarker signature is based on the world’s most advanced recombinant antibody microarray platform owned by Immunovia AB. The underlying technology is affinity proteomics. The biomarker signature hence exploits the body’s own detection network for the diagnosis of cancer. The initial retrospective clinical studies  have confirmed that the biomarker signature can accurately separate pancreatic cancer patients from healthy individuals. The implication is that the signature, once validated by a robust method, has a very high potential for the short-term uptake into clinical practice. The European dimension of the project lies in the validation of the biomarker signature that will make it possible for the first time to accurately diagnose pancreatic cancer in an asymptomatic stage (I and II) when the cancer is resectable. The results of the project will help to build up evidence that pancreatic cancer can be detected at an early stage, thus laying the basis for the future implementation of screening programmes of population groups at risk. The project stems from the unmet clinical need for the early detection of PDAC. Pancreatologists need a reliable biomarker for the early diagnosis (yes/no) diagnosis of pancreatic cancer. The test should primarily indicate whether the patient has cancer, not if the patient has a high risk of getting cancer. The new biomarker signature will address those needs and allow Immunovia to benefit from the tremendous business opportunity. Immunovia’s business strategy is based on extensive efforts towards validating the new biomarker signature by retrospective and prospective clinical trials. The validation