RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Forefront Research in 3D Disease Cancer Models as in vitro Screening Technologies' in the context of a Horizon 2020 call.

assistant: **Objectives**

PT11 is a convergence Portuguese region with innovative effort and performance bellow EU-average. Strengthening of the regional innovation system is crucial to create the pre-conditions for a knowledge based economy globally competitive. The socio-economical profile of the Northern region (PT11) presents a large contribution from the low educational records of the population and the predominance of traditional companies in the industrial sector (e.g., textile, shoes, etc). FoReCaST will attract to the Northern Portuguese region and UMINHO experienced human resources (ERA Chairs team) to settle in the region and to contribute to 5 strategic Research Lines (RLs) in cancer research field. The hiring of dedicated research staff will allow the nucleation of new strategic RLs, while simultaneously promoting the consolidation of pre-existing know-how by reinforcing some of lines of research already successfully exploited. Besides that, hiring experienced researchers will avoid the “brain drain”, train them in this high-tech field and finally increasing scientific international networking by exchanging of know-how. Moreover, PT11 will benefit from this project through the creation of profitable technologies and products (and consequently, business opportunities), increasing regional growth and income, and contributing to the reduction of the unemployment or even appearing of new SMEs. In this sense, FoReCaST will be fundamental to strengthen the regional innovation system in order to achieve scientific excellence and a higher level of integration in international knowledge networks. FoReCaST can be an important tool to boost even more the UMINHO scientific and innovation capabilities, its international visibility and cooperation, entirely aligned with Norte’s RIS3.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Grid aided computer system for rapid anti-cancer drug design' under Sixth Framework.

assistant: **Concept**

In the three years of this multidisciplinary research project, the 11-member, SME-led consortium would like to develop and refine methods for the enrichment of molecular libraries to facilitate discovery of potential anti-cancer agents. Using grid-aided computer technology, the likelihood of finding anti-cancer novel leads will substantially increase translating basic knowledge to application stage. In particular, through the interaction with novel technologies and biology, the R&D consortium aims at (i) developing focused libraries with a high content of anti-cancer leads; (ii) building models for prediction of disease-related cytotoxicity and of kinase/ HDAC/MMP and other enzyme inhibition or receptor antagonism using HTS results; (iii) developing a computer system based on grid technology, which helps to accelerate and automate the in silico design of libraries for drug discovery processes, and which is also suitable for future design of libraries for drug-discovery processes that have different biological targets (the result is a new marketable technology).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Econometric Modelling of Short Panels with Applications in Financial Econometrics' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

In recent years, there has been an increased availability of economic datasets that are characterised by a non-negligible amount of time-series information, as well as a large cross-section dimension. Unfortunately, in many cases, although the time-series dimension is not small anymore, it is not large enough for accurate estimation either. Examples of such datasets can be found in a variety of literatures: growth data, firm data (e.g. studies of insider trading activity), earnings studies (the popular Panel Study of Income Dynamics) and hedge fund returns, to name a few. Such panels are generally designated as short panels in the literature. Intuitively, the problem with short panels is a time-series finite-sample bias. This project’s main aim is to conduct a systematic theoretical and empirical research programme on modelling short panels in the presence of unknown and complex types of dependence across both time and cross-section. Inclusion of cross-section dependence is the central novelty of this project. This is motivated by my doctoral research where I showed that this type of dependence introduces new bias terms. The central theoretical objectives are to develop bias correction methods for (i) the Dynamic Autoregressive and Dynamic Probit/Logit models which are quite popular in applied research and (ii) the multivariate nonlinear and dynamic panel data models. The main empirical objectives are to a large extent concerned with univariate and multivariate volatility modelling using panels of financial data. As such, this project will contribute to the theoretical panel data and volatility modelling literatures, as well as the statistics literature, where the outlined small-sample bias has a long research tradition. In addition, as this project is concerned with mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Multiple-Discontinuity Induced Bifurcations in Theory and Applications' (MuDiBi).

assistant: **Innovation**

The theory or nonlinear dynamical systems was initially developed mainly for models with smooth system function. Since mid of 1900th non-smooth models became a focus or research interest as they provide an adequate description for many systems both in the nature and in engineering sciences. In the last twenty years it was shown that these systems possess many phenomena which can not occur in smooth systems. These phenomena are caused by the presence of so-called switching manifolds in the state space and their interactions with several invariant sets. However, until now mainly systems with one switching manifold were investigated. This represents an important intermediate step but is often not sufficient for explanation of the behaviour of many systems of practical interest. To understand possible behaviours of these systems and to achieve a desired behaviour via a suitable system design, it is necessary to understand the bifurcation structures occurring in multi-dimensional parameter spaces. For the bifurcation structures caused by interactions of invariant sets with one switching manifold, many valuable results were obtained in the last time. The proposed project addresses the following question: What are the basic principles organizing the bifurcation structures in low-dimensional maps with more than one switching manifold? The goal of the proposed project is to explain some generic bifurcation structures characteristic for these systems using a suitable extension of some novel investigation techniques developed for maps with one switching manifold with the concept of organizing centres in multi-dimensional parameter spaces. The practical relevance of the obtained results will be demonstrated by applications not only from the Engineering Science but mainly from the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Role of Endoplasmic Reticulum Stress in dendritic cells and immune-mediated lung diseases' (ERSTRESS).

assistant: **Concept**

My overall aim is to understand the physiologic and medical importance of lung dendritic cells (DC) and to define the suitability of inhibitors of their function for the treatment of inflammatory lung diseases like asthma and COPD.Lung dendritic cells (DC) play crucial roles in the regulation of lung immunity.  We still do not fully understand how they get activated in response to different types of environmental triggers like allergens, cigarette smoke and pathogens.  Although recognition of conserved motifs by pattern recognition receptors on DCs could be a key event, these stimuli are also accompanied by accumulation of unfolded proteins in the endoplasmic reticulum (ER). Cells respond by mounting the unfolded protein response (UPR) that acts to ameliorate protein folding, but intersects with metabolism, induction of alarm signals and cellular suicide mechanisms. I hypothesize that the presence of unfolded proteins and ER stress in DCs is a crucial endogenous danger signal that is vital to understanding their biology and their involvement in inflammatory lung diseases.My specific aims are to :1.define the fine tuning of ER stress pathways in various lung DC subsets in health and disease2. define the specific role of ER stress proteins XBP1, JIK and ORMDL3 in DCs3. test if interfering with ER stress pathways alters the course of inflammatory lung diseaseTo approach these aims, I have developed mouse models of lung disease that are centered around lung DCs and where ER stress pathways can be genetically deleted.  Using a combination of cell biological and immunological techniques I hope to achieve definitive answers as to how ER stress pathways regulate the function of DCs. Manipulation of ER stress pathways by drugs will have a major impact on very common diseases lik
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The fe65-app-x11 protein-protein interaction network: towards the generation of new molecular tools for alzheimer's disease diagnosis and therapy.' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

European Union Alzheimer's disease (AD) and related dementias affect 5% of persons aged 65-70 years, rising to 20% in those aged 85 and over. The full costs of AD to EU nations are very high. Due to demographic changes within Europe, the prevalence of AD and costs to the EU are likely to increase dramatically over the next four decades. There are currently no effective therapies for AD. Deposition of amyloidal beta peptide (Abita) within the brains of AD patients is believed to be central to the pathogenesis of the disease. Abita is derived by proteolysis cleavage from the precursor protein. APP. Recently, two families pf proteins, the Fe65s and Axis, have been shown to bind to APP and significantly influence APP processing and Abita production. The purpose of this project is to understand further the mechanisms by witch Fee and X11a influence APP processing and Abita production in AD. Another objective of the project is to explore the relevance of a recently discovered phenomenon (molecular misreading) witch causes the accumulation in AD brains of aberrant proteins. This work will lead to the generation of new AD animal models and to relevant knowledge to design innovative therapeutic strategies and new diagnostic tools.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Efimov trimers of ultracold cesium in optical lattices' to be submitted under Seventh Framework.

assistant: **Abstract**

Few-body physics with ultracold atoms has emerged as an exciting new research field, following experimental breakthroughs in the last few years. The universal behavior of few-body systems links areas of physics at vastly different energy scales, also bringing together scientific communities that are tradionally not connected. Efimov trimer states, very weakly bound quantum states of three particles, represent the paradigm of the field. The basic idea of the proposed project is to introduce tight external confinement into few-body physics with ultracold atoms, and to study Efimov trimers in situations of reduced dimensionality. This can be realized in one, two, or three dimensions using the powerful techniques of optical lattices. Such lattices are created in the standing-wave fields of different laser beams and represent a special expertise of the applicant. Ultracold ensembles cesium atoms near quantum-degeneracy, used by the host group for pioneering experiments on Efimov states, will serve as the model system. The project has three specific goals, which can be considered essential steps in few-body physics in systems with reduced dimensionality. First, a quasi-two-dimensional environment will be realized where the crossover from 3D to 2D will be studied. Second, Efimov trimers will be studied for systems of three atoms tighly confined to a single lattice site. Third, the new possibility to exploit three-body interactions to realize strongly correlated many-body systems in a three-dimensional lattice will be explored.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An ethical, legal and practical perspective on the impact of a new regulatory framework for the scientific use of animals on research and innovation' (ANIMPACT) targeting Seventh Framework.

assistant: **Abstract**

Research with animals is considered necessary to obtain certain vital knowledge for advancing health research and innovation, but the harm such research may cause animals is ethically problematic. The European legislation regulating animal experimentation is based on the need to balance the two important interests at stake: advancing research and protecting animal welfare. The public sensitivity of the issue is evidenced by the exceptional participation in the legislative process leading to a revised European legislation. Directive 2010/63/EU (presently under transposition into Member State legislation) will bring about substantial changes compared to the previous directive dating from 1986. One of the main objectives of revising this legislation is to create a greater harmonization of the governance of the use of animals in scientific (including medical) research for the European research area. The transposition is being accompanied by European Commission initiatives to promote a common interpretation of the legislation. However, major determinants of how research in Europe will be affected remain largely uncharted, in that little is published about how legal, ethical and scientific decisions about research will be made and how regulation will influence these decisions. A multidisciplinary team of academic researchers from different EU Member States will use literature reviews, questionnaires, interviews, and focus groups to provide a deeper understanding of how the regulation interacts with research and innovation through the new common legal framework for animal experimentation in the EU. ANIMPACT will address the effectiveness of the new Directive and the current law in relation to other established norms in ethics, law, and scientific research, with focus on its in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Exploiting Factory of the Future projects through Enhanced Clustering towards Technology Transfer, Innovation and Value creation for European industry.' (EFFECTIVE), addressing dissemination and exploitation.

assistant: **Impact**

The EFFECTIVE project foresees the following objectives:• analyse business trends and market prospects, and perform reviews & workshops to get a consistent set of information for clustering and exploitation of FoF projects activities and results;• develop and industrial exploitation framework for the promotion and transfer of FoF projects activities and results, and structure networks & alliances to achieve such objectives;• active clustering of FoF activities and results based the identification of six major technological FoF areas, addressing also potential sectors and applications for exploitation and transfer of the considered clusters of technologies;• analyse best practices and case studies of FoF results clustering, exploitation and transfer through 4 relevant regional case studies in low-, medium- and high-technology intensive sectors, by means of the involvement of innovation actors of the considered regions;• set up instruments for adequate monitoring of FoF activities clustering and exploitation during the project life-time and beyond, to ensure an effective implementation at programme level;• identification of future FoF priorities within the technological areas of the addressed clusters and roadmapping of needed further research and innovation actions;• promote and disseminate the EFFECTIVE project results and tools to a large community of European actors through qualified networks and associations (such as EFFRA, Enterprise Europe Network, EBN and EURADA);• involve international experts and create strategic links with international initiatives to support the full achievement of EFFECTIVE objectives on global scale.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Numerical Analysis for Stable AI' (NumAStAI) under Horizon Europe.

assistant: **Objectives**

From a numerical analysis perspective I will identify, quantify and mitigate vulnerabilities in current artificial intelligence (AI) algorithms.Novel mathematical research will emerge along six overlapping axes:Inevitability: rigorously understand the inescapable endgame of the attack-versus-defence paradigm. Under what conditions is it inevitable that adversaries willsucceed? Formalizing such conditions will allow us to understand and, where possible, overcome current AI instabilities.Editability: study algorithms that stealthily change a small number of parameters. This scenario is highly pertitent when new AI is built on top of third-party, foundation models. It also opens up the possibility of fixing errors on-the-fly without the need to re-train.Targetability: examine whether under-represented categories in the training data are more susceptible to adversarial attacks. This topic raises a key,and currently overlooked, issue in the ethical use of AI.Universality: develop linear, sparse, low rank mappings that create adversarial attacks. These new functions will expose novel, low-cost, threat mechanisms, but will also give insights into the decision boundary landscape. Roundability: use state-of-the art probabilistic rounding error analysis to justify large-scale, low precision computations.I will study (a) why current AI technologies appear to defy traditional worst-case floating point error bounds, and (b) whether low precision can be exploited byan adversary.  Legislatability: devise easy-to-interpret results and practical case studies that can inform public opinion and impact the design of appropriate AI legislation.The project identifies high-profile open questions requiring tools frommatrix analysis, optimization, backward error analysis, condition number theor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Investigating the TORC1 signaling pathway in the moss Physcomitrella and its application for enhanced production of valuable pharmaceutical compounds' under Horizon Europe.

assistant: **Concept**

The Target of Rapamycin Complex 1 (TORC1) signaling pathway, involved in the coordination of cell growth and metabolism, is highly conserved among eukaryotes, including seed plants and algae. Studies have shown that its activity could be tuned to enhance plant growth, yield and resistance to stress, or accumulation of triacylglycerol in algae, thus indicating that its power could be harnessed to improve diverse plant biotechnological applications. In this project, I aim to characterize the TORC1 pathway for the first time in the moss Physcomitrella (Physcomitrium patens), a model organism of non-seed plants, using protonema cells as a study system. This is linked to another important goal, to test whether the activity of TORC1 can be modulated in order to improve moss-based biotechnological applications. Besides the identification of a functional TORC1 in Physcomitrella, I will develop transgenic lines with hyperactive TORC1 signaling, phenotypically and metabolically analyzing them, and in collaboration with Mosspiration Biotech, test if these lines could produce more human recombinant complement proteins or the drug artemisinin, used to treat patients with complement disorders or malaria, respectively. Enhancing this yield will result in a stable, sustainable and eco-friendly production platform. It would also lead to a reduced price, for instance of artemisinin-based treatments, thus allowing poor communities most affected by malaria to contain the disease. Should this project be successful, it will open the door to improve the yield of diverse well-established products from Physcomitrella, valuable metabolites, active pharmaceutical ingredients and biopharmaceutical proteins.


**Keywords:** Physcomitrella, bryophytes, plant TOR signaling, TORC1 hyperactivation, pla