RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Temporal dependence of enhancer function' (TimedEnhancer).

assistant: **Innovation**

During vertebrate development, genes are regulated by distal regulatory elements, presumably via physical contacts between enhancers and transcription start sites. Alterations in enhancer sequences and/or their interactions with gene promoters can perturb gene expression, leading to developmental disorders and cancers, which argues for their pivotal role in transcription. Conversely, enhancer-promoter contacts can also be uncoupled from gene activation during developmental transitions and in single cells, where they are highly heterogeneous. Thus, the relationship between enhancer-promoter interactions and transcription is frequently indirect and the mechanisms that dictate when promoter-enhancer contacts can result in gene expression differences remain unknown. The core hypothesis of this proposal is that it is the timing of promoter-enhancer communication that instructs gene activation. Aim1 will examine whether and how the precise timing of enhancer-promoter interactions contributes to transcription. My group will determine which molecular mechanisms during transcriptional activation are regulated by enhancers contacting their target genes at different time points during embryonic stem cell differentiation.Aim2 will investigate how present and preceding enhancer-promoter contacts relate to transcriptional activity and transcription factor binding in single cells. My group will develop a genomic approach to trace the memory of preceding interactions at gene regulatory elements, thus adding a novel temporal dimension to current single-cell methods. By longitudinally combining cutting-edge genomic, single-cell and activity perturbation assays, my group will uncover how genes integrate regulatory inputs from several enhancers and assess how the timing of genome folding m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cost of test reduction: assessment of IC tester for high volume and digitized analogue applications' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

- To prove the new generation ITS 900CV tester, which is specifically targeted at the microcontroller market, in the high volume production line of SGS-Thomson in Rousset.- To demonstrate the effectiveness of the hardware and software developments achieved during previous projects.- To reduce the 'Cost of Test' by a factor of two over the equipment's predecessor.- To compare 'Cost of Test' using 'parallel by four' of a 'parallel by two' format.The performance of the new generation ITS9000CV of Schlumberger will be assessed at the IC manufacturing facilities of SGS-Thomson in Rousset, France. To lower IC production costs it is the aim of the project to demonstrate cost of IC test reduction by a factor of two. Production batches of different ICs will be run and test costs will be compared between the ITS9000CV and the previous generation testing equipment of the same supplier.The evaluations will be done using two high volume products; one, a mixed function microcontroller, the other, a pure digital device.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Brain-inspired Computational Memory' (BRICMEM).

assistant: **Innovation**

Deep neural networks (DNNs) have transformed the field of AI in recent years. However, a significant challenge persists in the form of inefficient hardware implementations of DNNs. Computation in memory (CIM) is an emerging approach that tackles the processor-memory divide in modern computing systems, enhancing their suitability for DNNs. CIM draws inspiration from certain computational principles found in the human brain, such as hard-wired neural networks and analogue processing.A key question is whether other attributes of information processing in the mammalian brain could help overcome conventional CIM challenges and lead to a radically enhanced variant of CIM. In biological brains, information is holographically encoded, without distinctions between significant bits, potentially allowing computing-in-superposition on the same hardware. Biological neural networks also use randomness constructively for information representation and computation. Time is a valuable computational resource in the brain, used for information representation and processes. Unlike current CIM-based DNNs, biological neural networks operate in three spatial dimensions.BRICMEM aims to develop a revolutionary brain-inspired computational memory by leveraging superposition, randomness, time, and space. For computing in superposition, the goal is to store multiple DNN models within the same computational memory. Randomness will be systematically used to enhance conventional DNN functionality and to develop new types of DNNs. Temporal encoding will be explored as an energy-efficient communication method between CIM cores, with novel mathematical functions operating on elapsed time. Additionally, we will utilize the third spatial dimension to improve weight capacity and to implement specific neura
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'TRANSAFELOAD: Testing the real behaviour of packaged loads during transport'.

assistant: **Concept**

Pallets are the standard unit for load and transport since they enable efficient handling and storage of goods. Merchandise is placed on a standardized structure (pallet) and wrapped with film to ensure rigidity and stability of goods during shipping. Currently, optimizing the packaging of pallets is a delicate issue: over-packaging leads to extra costs (around 30% extra material is user to ensure the packaging integrity during transport) while defective packaging induce safety hazards and economic losses valued at € 50000 million/year worldwide.The European concern about safety during transportation of goods is reflected in the 2014/47/EU directive, which will oblige all the agents involved during the freight shipping including the load packagers) to take responsibilities on security matters by 2017. Transafeload is the first solution able to simulate the real behaviour of packaged loads up to 2 Ton during transport enabling optimizing packaging costs and ensuring safety issues related to directive.: Transafeload is the first European testing equipment able to simulate the real effect of vibrations, drops and lateral forces on packaging during transportation. Our testing equipment is able to: a) Reproduce the real vibrations experienced by packaging during transport thanks to a patented pitch and roll mechanism B) Assess the effect of horizontal accelerations/decelerations and impact according to all the current worldwide standards, C) Testing drop resistance in an accurate way for heavy loads. Transafeload provides goods’ manufacturers with a tool for reducing losses of goods due to defective packaging as well as reducing the amount of packaging material used and increasing safety during cargo shipment.


**Keywords:** packaging optimization, safe transport, vibration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unravelling the mechanisms of competence induction by antibiotic stress in Streptococcus pneumoniae' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Despite the introduction of several vaccines, the human pathogen Streptococcus pneumoniae remains one of the leading bacterial causes of mortality worldwide, killing 1 million of children each year. In developed countries, the rise of multi-drug resistance in S. pneumoniae during last decade is a serious cause of concern, since the patient is more likely to require hospitalization consuming high health resources, and increasing the risk of death.The main mechanism by which S. pneumoniae acquire and spread antibiotic resistance is by activation of the competence state that allows the uptake of exogenous DNA. Strikingly, competence is induced by several antibiotics, but the molecular mechanisms driving competence development are poorly understood. Our approach integrates the use of promoter-luciferase fusions to competence genes, transposon-mutagenesis and -sequencing, total RNA sequencing, knockout strains constructions and time-lapse fluorescence microscopy, to identify clinical antimicrobials that induce competence and unravel its underlying molecular mechanisms. Data generated in this project will provide a better understanding of the mode of action of these antibiotics and give valuable molecular insights into the evolution of antibiotic resistance in S. pneumoniae. Finally, we will test thousands of pairwise drug combinations in a novel high-throughput screen to identify inhibitors of the competence process. This highly relevant project will provide new pre-clinical data for future novel treatment strategies against bacterial infections and the mitigation of the spread of antibiotic resistance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Air-Sea Exchanges and Fluxes in the Mediterranean Sea Region from Satellites, In Situ Data and Models' (MED-AIRSEA-FLUX), addressing dissemination and exploitation.

assistant: **Impact**

Air-sea fluxes represent exchange mechanisms between the ocean and the atmosphere and include momentum fluxes (winds), heat fluxes (radiation, sensible and latent heat fluxes) as well as trace gas fluxes (pCO2). We propose a unified study of these fluxes focusing on the energy, water and carbon cycles in the Mediterranean Sea region under present and future climate conditions. To achieve this goal we will firstly use in situ measurements and satellite estimates of the fluxes and the fields they are derived from (sea surface temperature and salinity, surface winds, air humidity, air temperature, cloudiness) and describe flux variability at scales that range from daily to interannual and from local to continental. We will then evaluate the uncertainties in the satellite estimates compared to in situ measurements and finally we will assess model fidelity against both observations and satellite data. A hierarchy of models of the Mediterranean Sea circulation will be used with different discretizations and coupling methods to the atmosphere in order to simulate present and future scenario air-sea interaction cycles under changing climate conditions. The observational and model data analysis will rely on advanced statistical techniques such as clustering and statistical downscaling. Clustering will describe the dynamical regimes that govern the air-sea exchanges and statistical downscaling will complement the dynamical downscaling modeling experiments.The Mediterranean Sea region has already experienced large shifts in the interaction between atmosphere and ocean particularly in the hydrological cycle as documented in the IPCC AR4. At the same time, the Mediterranean Sea through its outflow to the world ocean affects the global thermohaline circulation and plays an important
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Providing an open collaborative space for digital biology in Europe' (EOSC-Life) targeting Horizon 2020.

assistant: **Abstract**

EOSC-Life brings together the 13  Biological and Medical ESFRI research infrastructures  (BMS RIs) to create an open collaborative space for digital biology.  It is our joint response to the challenge of analysing and reusing the prodigious amounts of data produced by life-science. Managing and integrating this data is beyond the capabilities of most individual end-users and institutes. By publishing data and tools in a Europe-wide cloud EOSC-Life aims to bring the capabilities of big science projects to the wider research community.  Federated user access (AAI) will allow transnational resource access and authorisation. EOSC-Life establishes a novel access model for the BMS RI: through EOSC scientists would gain direct access to FAIR data and tools in a cloud environment available throughout the European Research Area. EOSC-Life will make BMS RIs data resources FAIR and publish  them in the EOSC following guidelines and standards (e.g. EDMI). Overall this will drive the evolution of the RI repository infrastructure for EOSC and integration of the BMS RI repositories. EOSC-Life will implement workflows that cross disciplines and RI boundaries and address the needs of interdisciplinary science. Through open hackathons and bring-your-own-data events we will co-create  EOSC-Life  with our user communities , providing a blueprint for how the EOSC supports wide-spread and excellent data-driven life science research. EOSC-Life will address the data policies needed for human research data under GDPR. Interoperable provenance information describe history of sample and data to ensure reproducibility and adherence to regulatory requirements.The goal of the EOSC-Life project is to make sure that life-scientists can find, access and integrate life-science data for analysis and reus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Reverse logistics chain optimisation in a multi-user trading environment'.

assistant: **Objectives**

The objective of RELOOP is to deliver an integrated tool and methodology aimed at optimising and planning take-back logistics (TBL) supply-chains and routes simultaneously with respect to the cost of TBL, the environmental impact of TBL, a product's recycling strategy, and today's as well as the future's legislative constraints.RELOOP, therefore, aims, - To provide an integrated trading environment for logistics, recycling and manufacturing companies; - To provide operational support for TBL and recycling transaction on the administrative side through predefined forms and procedures; - To make the results available as a on a Global Engineering Network (GEN) for the required instant update of the information database; - To employ a Geographic Information System (GIS), an emerging technology for numerous geographically related applications, for visualisation and user friendliness; - To provide multi-user and multi-site capability to simultaneously support the entire TBL supply- chain, consisting of manufacturing, collection, logistics and recycling; - To support TBL supply-chain companies to plan TBL optimal locations of new sites; - To provide guidelines to optimise product design with respect to an optimised TBL; - To cover a most comprehensive European network of road, rail, water and airways; - To provide solutions for the urgent electronics products sector based on a generic approach in order to allow adaptations to other product types. An initial study will provide examples of best practice from European companies successfully operating take-back activities of electronic goods. The entire recycling and TBL chain will benefit in terms of increased business at reduced cost and environmental impact. The RELOOP tool will improve the logistic chains from the last end-use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Biomass-derived Microporous Carbon Adsorbents for CO2 Capture and Storage'.

assistant: **Objectives**

This Marie Curie proposal, BIOADSORB aims the development of new and low cost biomass-derived carbon adsorbents for CO2 capture using the following strategies:(i) a new synthetic route based on hydrothermal carbonization (HTC) process and in situ salt templating for the efficient conversion of waste biomass into functional porous carbon materials (HTCs) for CO2 capture(ii) a theoretical approach based on molecular simulations and density functional theory to model and understand the HTC structure along with the adsorption and transport behavior of CO2 and other gases in those structures.(iii) An in-silico method to demonstrate the potential of HTCs for CO2 capture from real industrial streams in a cyclic separation process.The proposed synthetic path will bring new horizons to the production of biomass-derived microporous carbon materials. The theoretical studies will demonstrate the potential of the as-synthesized materials for CO2 capture from industrial streams in a cyclic separation process. The theoretical studies will also advance the understanding of the mechanism of surface-gas interactions, gas adsorption and transport behaviour inside the complex pore matrix.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Decoding the molecular control of bud dormancy release in trees' in the context of a Horizon 2020 call.

assistant: **Objectives**

Plants lack a nervous system and central decision-making organ like a brain, but can nevertheless sense and respond to environmental cues that play crucial roles in regulating their growth, through poorly understood mechanisms. The aim of DECORE is to elucidate these mechanisms, particularly those underlying the low temperature-mediated control of bud dormancy in the model tree hybrid aspen. A recent discovery in the host lab, pinpointing AGL8 as a low temperature responsive transcription factor involved in bud dormancy release, has lead us to hypothesize that AGL8-mediated transcriptional control of the plant hormone gibberellin, mobile signaling component FT1 (a tree ortholog of Arabidopsis FLOWERING LOCUS T) and cell-cell communication together orchestrate bud dormancy release. In DECORE, Dr. Pandey will test this hypothesis by deciphering the interplay between gene expression, hormonal regulation and cell-cell communication during dormancy release, and simultaneously acquire skills in cutting-edge techniques like transmission electron microscopy, immunocytochemistry and mass spectrometry in leading environments at the host SLU/UPSC (Umeå, Sweden) and via secondment to CNRS (Bordeaux, France). Synergistically complementing the skills in biochemistry and genomics gained during his PhD, this training will provide Dr. Pandey with a unique opportunity to broaden his technical and theoretical expertise, which will promote a successful achievement of the project’s goals, open new vistas in developmental adaptation, and support his ambition of becoming a research leader. Dr. Pandey will follow a personalized career development plan to enhance his skills in communication, grant writing, public engagement and student mentoring. Thus, DECORE will contribute fundamental knowled
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Optimization of Sole Leather Drying by Heat Pump' to be submitted under Fourth Framework.

assistant: **Abstract**

The problem of drying of vegetable tanned sole leather is sharp, because of the presence of high quantities of water soluble matter and the great tendency for oxidation of tannins. During drying process water soluble substances are often extracted from the leather, reducing the quality of the product. On the other hand high temperatures cause oxidation of tannins, giving an undesirable dark brown colour, while drying in low temperature requires long time. The influence of drying process thus may be dramatic, both on quality of sole leather and on the production cost. In the proposed project, the application of a sole leather dryer will be studied equirref with a heat pump, instead of a simple exposure into the open air or vacuum drying used at present. The concrete objectives of the research will be: - to define the best values of relative humidity, temperature, air circulation etc. - to obtain sole leather of high quality - to reduce drying time - to avoid heavy costs due to defects from uncontrolled drying.