RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Codeine Use, Misuse and Dependence'.

assistant: **Concept**

Contemporary research has underscored the need for ‘increased pharmaco-vigilence’ around codeine dispensing as the most commonly consumed opiate worldwide. Codeine represents an interesting quandary in terms of its regulated status, with individuals varying in their metabolism of codeine, estimation of safe dosages, and abuse potential. Within user trajectories of codeine use, a variety of sub groups exist in the form of the elderly, youth, parents, recreational, problematic and opiate dependent drug users, and each with their own motives, patterns and outcomes for use. Increases in treatment uptakes relating to codeine dependency and concerns for appropriate design of treatment protocols have been recorded globally. There is a clear need for this unique collaboration to present data on codeine user profiles so as to inform the design of protective mechanisms in the pharmacy profession to track, monitor , support and refer codeine misusers. The research aims to quantify the extent of codeine use, misuse and dependence in three countries (Ireland, United Kingdom and South Africa), with focus on therapeutic and non therapeutic use, so as to create user profiles of use and abuse and capture individual user, pharmacy, medic and treatment provider perspectives. Data will be used to inform the design of pharmacy based brief interventions and customer monitoring systems, continuing staff training and management of appropriate treatment interventions.  A mixed method approach will commence with a meta-analysis and systematic review of literature, which along with national pharmacist, medic and treatment provider surveying, will inform the design and implementation of sweep surveys of individuals purchasing OTC codeine in pharmacies, internet based codeine user focus groups targ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'China Europe Network on the NET' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

CENNET will maintain and further develop the relationships established between China and Europe during the past 7 years of co-operation in the domain of Manufacturing Engineering and Integration. Specific activities will include: organisation of workshops in China and in Europe, invitation to Chinese Partners for short visits in Europe, development of a CENNET Website and dissemination of the results of China-European co-operation in Europe.Objectives:At a macro level, CENNET will seek to develop a strategic relationship between the Automation Initiative of the China High Tech 863 Programme and the Electronic Commerce Digital Business activity of the IST Programme.Specifically CENNET will seek to encourage co-operation between projects sponsored by the 863 programme and the IST programme and stimulate the development of joint projects in the future.At a micro level CENNET will:- Disseminate throughout Europe and reciprocally in China, information on R&D and industrial activities in Electronic Commerce and Digital Business in China;L- encourage the development of cooperation projects between Europe and China;- encourage the exchange of students, industrial researchers and engineers;- seek to encourage the development of common standards;- advise the E.C. and the Chinese Ministry of Science and Technology (MOST).Work description:CENNET Project's work is defined into five Workpackages as follows:WP1 - organisation of 2 workshops in China (one in Beijing and another in IT representative Chinese region) with a very large audience (25% of Europeans) over a period of 18 months.WP2 - development of a strong, powerful and interactive web site; development of a server to support the existing network to establish the contact points for the industries as well as universities in Eur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '2D Topological Superconducting Single Photon Detector Devices' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Superconducting single photon detectors are critical components for emerging quantum technologies due to their high detection efficiencies, short jitter, photon number resolution, high maximum and low dark count rates. These devices may enable new ground-breaking applications in topological quantum computing and quantum internet. Niobium-based nanowires (Nb, NbN) are some of the most used superconductors for photodetection, but their material characteristics, device jitter and efficiencies cannot be effectively tuned or reproduced for scalable quantum technology deployment. The structural and electronic properties of these nanowires are not suitable for scalable cryogenic or room temperature readout. The challenges in growing high-quality quantum materials consistently provide a significant bottleneck against the development of quantum technologies that might efficiently interface with conventional microelectronics. In my ERC Grant (948063), we are using our pulsed laser deposition (PLD) and molecular beam epitaxy (MBE) expertise for magnetic topological insulators (MTI) and garnets for spintronic and superconducting devices with high conversion efficiency between electronic spins and charges. Here, I propose to develop three prototypes and obtain their patents: (1) Three MTI superconductor-based single photon detector prototypes with beyond state-of-the-art high efficiencies and ultralow jitter owing to the unique properties of MTI such as ultrafast sub-ps magnetization reversal, ballistic transport of Dirac electrons along the interfaces and integrated spin logic. (2) We are going to provide a steady supply of high-quality superconductor and spintronic films (NbN, MTI, and magnetic garnets) to accelerate basic and applied research, which is a market growing with about
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A molecular dynamics study of the structure and properties of the haemoglobin protein' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Our project is centered on an investigation of the properties of the haem group, which is the reactive center (prosthetic group) of the haemoglobin protein. Despite its wide biological importance, no study in the past has been able to elucidate the molecular mechanisms underlying the activity of the most important proteins carrying the haem group. Our study will be performed with a computational method (the CarParrinello scheme) that allows now to treat molecules of the size of the haem group and to investigate the interplay of structural, dynamic and electronic aspects in this molecule. Our main objectives are: 1. We will determine the ground state geometry of the haem group and the relative stability of its 15 different isomers. 2. We will analyze the dependence of the ionic and electronic structure on the oxidation and spin state of the iron atom (this dependence is crucial for the biological activity of the haem group). 3. We will analyze the binding of the haem group with 02 and CO, both for the isolated fragment and in the presence of the histidine F8. Besides the specific results expected from the computation described above, the project will provide experience and preliminary results for more ambitious developments. For example, the study of model proteins carrying the haem group are not far from the present computational capabilities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biomarker Research Alliance for Diagnosing Heart Disease in the Ageing European Population' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The ageing of the European population represents a rapidly rising social and economic challenge. Especially cardiovascular morbidity increases with age, but unfortunately, elderly patients are often difficult to diagnose due to confounding factors, leading to uncertainties in clinical decision making with huge impact on patients’ outcomes. Hence, there is an unmet need for novel biomarkers for more accurate diagnosis, risk assessment, and clinical outcome prediction for both acute and chronic cardiovascular diseases in the elderly.The BestAgeing consortium aims to improve this lack of diagnostic capabilities by developing and validating innovative omics-based biomarkers particularly for elderly patients – supporting healthy ageing in Europe. Our study design addresses the most frequent and severe cardiovascular diseases of elderly patients by incorporating the appropriate disease cohorts and biomaterials from European populations. We aim to develop new omics-assays to diagnose cardiovascular disease, estimate risk, and monitor the response to treatment in elderly. This is envisaged to enable a more stratified and economic delivery of medicine. We expect that BestAgeing will generate novel European medical technologies that can improve the efficacy and efficiency of our care for elderly patients, which will also impact on socioeconomic wealth in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'An Integrated Computer Modelling Framework for Subject-Specific Cardiovascular Simulation: Applications to Disease Research, Treatment Planning, and Medical Device Design' in the context of a Seventh Framework call.

assistant: **Objectives**

Advances in numerical methods and three-dimensional imaging techniques have enabled the quantification of cardiovascular mechanics in subject-specific anatomic and physiologic models. Research efforts have been focused mainly on three areas: pathogenesis of vascular disease, development of medical devices, and virtual surgical planning. However, despite great initial promise, the actual use of patient-specific computer modelling in the clinic has been very limited. Clinical diagnosis still relies entirely on traditional methods based on imaging and invasive measurements and sampling. The same invasive trial-and-error paradigm is often seen in vascular disease research, where animal models are used profusely to quantify simple metrics that could perhaps be evaluated via non-invasive computer modelling techniques. Lastly, medical device manufacturers rely mostly on in-vitro models to investigate the anatomic variations, arterial deformations, and biomechanical forces needed for the design of stents and stent-grafts. In this project, I aim to develop an integrated image-based computer modelling framework for subject-specific cardiovascular simulation with dynamically adapting boundary conditions capable of representing alterations in the physiologic state of the patient. This computer framework will be directly applied in clinical settings to complement and enhance current diagnostic practices, working towards the goal of personalized cardiovascular medicine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of High Entropy Alloys (HEAs)-based Electrocatalysts for Clean Hydrogen Production via Seawater Splitting' under Horizon Europe.

assistant: **Concept**

The DEEPSEA project aims to harness the unique properties of High entropy alloys (HEAs) to address the critical challenge of efficient and sustainable hydrogen production through seawater splitting. HEAs, composed of five or more metal elements, exhibit exceptional mechanical strength, corrosion resistance, and stability. These characteristics make them promising candidates for advanced electrocatalysts. The DEEPSEA project focuses on predicting novel HEAs using density functional theory, evaluation of thermodynamic quantities and active sites responsible for water oxidation, and guiding practical synthesis. Structural and electrochemical characterization of newly synthesized HEAs will be carried out to confirm the phase formation and electrochemical activity. The primary objective of this project is to study the water-splitting activity of HEAs for green hydrogen production via seawater splitting. The key electrochemical performance metrics including overpotential, Tafel slopes, and long-term stability, will be evaluated to identify the most efficient compositions of HEAs. Various HEA compositions and structures will be optimized to enhance the bifunctional seawater-splitting activity. The project's expected outcomes include the development of HEAs with lower overpotentials than commercial HER/OER catalysts at high current densities and excellent electrochemical stability. This research project will not only contribute to the advancement in clean hydrogen production technologies but also provide valuable insights into the design and optimization of advanced materials for energy applications. By addressing the pitfalls of clean hydrogen production, this project aligns with global efforts to move towards a carbon-emission-free future, offering a promising roadmap for the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Building a 3D innervated and irrigated muscle on a chip.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The aim of the MyoChip project is to build a 3D human skeletal muscle irrigated by vasculature and innervated by neurons. The reconstituted 3D muscle will mirror the architecture and function found in vivo, namely in shape, contractility and microenvironment, while irrigation by a vascular network and innervation by human motor neurons will bring additional physiologic pertinence to it. This organ-on-a-chip technology will have numerous applications including but not limited to research on muscle building and aging, drug testing and screening, as well as prosthetics and biorobotics. The feasibility of the project relies on the interdisciplinary approach which joins a team of cell biologists, material engineers, experts in microfluidics and mathematical modellers. The architecture of skeletal muscle and its regenerative capabilities make muscle a prime candidate to push the 3D tissue engineering field. As such the project will lay the technical, material and methodological foundations to tackle the next generation of complex organ-on-a-chip systems that the MyoChip consortium can exploit for the generation of highly complex 3D in vitro systems of many organs.


**Keywords:** Skeletal muscle, vasculature, neuronal network, biomatrices, computational modelling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'The economics of cities and regions: European integration and new technologies'.

assistant: **Objectives**

Besides taking stock of international and European research in the field, we expect the proposed conferences to advance the field of study with respect to the following dimensions. First, economic geography in Europe has tended to be strongly biased towards theoretical studies. The so-called 'new economic geography' (NEG) has led to a large number of theoretical developments with empirical work lagging far behind. Over the last couple of years, European research has started to deal with the empirics of the NEG (Combes and Lafourcade, 2001, Redding and Venables, 2001). More economists are now pursuing this line of research in Europe, but most of the work is still in progress. The proposed conferences would therefore have an extremely beneficial effect in bringing together these researchers and their current work.In addition, the conferences will promote dialogue among geographers and economists. Until recently regional and urban economics has been an extremely fragmented field of investigation. For instance, the NEG has developed quasi-autonomously. The gap with urban economics has since then been filled rather successfully following Paul Krugman's interest in urban issues and joint-work between other proponents of the NEG and urban economists. It is very important to maintain this dialogue. Prominent geographers have agreed to participate and organise sessions. This dialogue should become more fruitful as it will involve junior researchers on both sides.Finally, the renewed interest in spatial issues in the 1990s has attracted many young scholars who are now 5 to 7 years into their academic career. Within Europe, thanks to a previous European Science Foundation grant and CEPR conferences, the links among them are very strong. With other areas of the world, contacts amon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Synthetic biology of non-ribosomal peptide synthetases to generate new peptides' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Natural products (NPs) generated by microbial non-ribosomal peptide synthetases (NRPS) represent several very important and valuable clinical antibiotics, immune-suppressive and anti-cancer drugs. NPs have gone on to inspire several synthetic peptides that are used clinically, but contain amino acids (AAs) or other building blocks that are not found in nature. However, with >500 identified AAs and additional peptide modifications like glycosylation or cyclization, the chemical diversity in NRPS-derived peptides is far larger than proteins and has not yet been fully explored. The modular nature of NRPS suggests the possibility to manipulate them, subsequently leading to the production of non-natural NPs. With an eXchange Unit (XU) concept, developed in Photorhabdus, Xenorhabdus and Bacillus, we have recently identified efficient ways for NRPS manipulation enabling the de novo assembly of novel NRPS for the production of new-to-nature NPs in excellent production yields of >250 mg/L. Within SYNPEP we will expand this approach to other bacterial genera producing peptide NPs. We will identify unusual NRPS systems, analyse them bioinformatically, validate the function of novel NRPS units experimentally and combine high-throughput molecular biology, microfluidics for bioactivity screening, rapid NP identification and structure elucidation to produce potentially any peptide or a peptide library of 2-15 amino acids in <4 weeks, in a semi-automated manner. In contrast to chemical peptide synthesis this production pipeline is more economical, sustainable and scalable. The NPs are produced by bacterial cells in aqueous media using cheap energy sources and the bacterial cultures can be easily scaled up when larger NP amounts are needed. We will also develop NRPS units that accept sy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Therapeutic strategies for boron neutron capture therapy (BNCT)'.

assistant: **Objectives**

The proposed cluster, entitled therapeutic strategies for bnct, aims to combine a basic understanding of the fundamental issues, along side the social and economic aspects of multi-national studies, and to utilise this in operating clinical trials. The overall objective is to implement bnct which is based on targeting tumour cells. Through optimisation of resources and know-how, the individual goals of each sub-project should be greatly enhanced. It will be possible to analyse some fundamental issues of the application of boron (the delivery drug) compounds to enhance the understanding of the delivered radiation dose and its effect on the targetted cells, but also allow a review of the working interaction between this wide range of participants and judge whether such a large, trans-national project, performed at a unique facility can be economical for europe.