RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Fundamental physics in the era of gravitational-wave astronomy' (FunGraW) targeting Horizon 2020.

assistant: **Abstract**

The first gravitational wave (GW) detections by the Laser Interferometric Gravitational-wave Observatory (LIGO) are an historical landmark. These detections opened a completely new window to the Universe and officially marked the beginning of GW astronomy.GWs travel almost unimpeded through the Universe, thus conveying clean information about their sources. This gives us a unique opportunity to test the nonlinear regime of Einstein’s theory of general relativity (GR) to unprecedented levels. Indeed, the GWs detected so far were emitted by the merger of binary black holes (BHs) which are the prototypical sources to investigate gravity in its most extreme regimes. However, the true potential of GW observatories to discover new physics beyond of current knowledge is far from being fully explored. In fact, besides probing the nature of compact objects and testing GR, GW detectors may also revolutionize our understanding of particle physics, dark matter (DM) and even possibly quantum gravity. At small scales, with the advent of precision GW physics we will be probing regions closer to the BH horizon, potentially ruling out or confirming alternatives to BHs that predict corrections at the horizon scale. On the opposite side of the spectrum, GWs may also give us hints about the nature of large scale anomalies, such as the existence of DM. For example, light bosonic fields around compact objects, i.e. BHs and neutron stars (NSs), can trigger superradiant instabilities and emit long-lived monochromatic GWs that can be used to either probe the existence of new particles beyond the Standard Model or, in the absence of detections, impose strong constraints on their masses and couplings. The prime goal of this proposal is to understand what GWs can tell us about fundamental question
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Industrial scale PET chemical recycling via an innovative glycolysis process' under Horizon 2020.

assistant: **Concept**

The massive industrial use of Polyethylene Terephthalate (PET) poses serious economic and environmental problems due to its poor recyclability. Current PET disposal options include incineration, landfilling and recycling while a relevant amount is still dumped into oceans. Landfilling and incineration are however outdated since environmentally unsustainable. Recycling is the preferred option, but a series of technological barriers limit the recycling into high-quality rPET (recycled PET).The ChemPET project aims to scale-up a cutting-edge chemical recycling technology, based on glycolysis, for PET based waste converting it into monomer BHET.Currently, there are no alternatives which guarantee efficient results at industrial scale considering heterogeneous PET feedstock. BHET can be newly used as raw material in the production of virgin PET instead of the terephthalic acid (TPA) and the ethylene glycol (EG) that derive from crude oil. This determines advantages for the PET value chain in terms of environmental sustainability, competitiveness and job creation. ChemPET will help Europe to achieve the “Zero Plastics to landfill by 2025”, promoting the Circular Economy and reducing Europe dependency on fossil feedstocks. ChemPET project foresees the technical improvement of ChemPET technology and the valorisation of by-products.After the optimization of the BHET production phase, GARBO will collaborate with many stakeholders across plastic industry value chain to maximize the business opportunities and foster the uptake of ChemPET technology. The production of chemical recycled PET (crPET) from BHET will close the loop supporting the growth of the circular economy thus reshaping the PET value chain at whole. Large occupational benefits are expected by the replication of Chem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Advanced multiscale simulation of DNA'.

assistant: **Concept**

The availability of new computers and software is making possible the theoretical representation of DNA, increasing then our knowledge on the behavior of one of the most relevant biological macromolecules. Unfortunately, current simulation procedures present two major problems, which handicapped their use: i) classical force-fields present well known biases, which limit their accuracy; ii) current atomistic procedures are limited to study systems in the range of 100 base pairs (around 34 nm long), while the DNA of the simplest prokaryotic organisms is one billion times larger. The main objective of this proposal is the development of a multiscale simulation technology for the study of DNA, which will cover, with different levels of resolution, but with the same physical roots, the entire range of DNA scales, from nucleobase (Ǻ-scale) to the human genome (m-scale). Our roadmap will start for the development of a polarized force-field which will be parametrized against a variety of experimental and theoretical data. In a second stage, we will analyze a very large number of DNA sequences in different epigenetic and packing states and we will create a MoDEL-like database of DNA trajectories. In a third stage we will derive coarse grained and essential dynamic-based strategies for ultra-fast accurate simulations for medium to long segments of DNA.  In the last stage of this project we will develop a new mesoscopic model, which will go beyond the harmonic nearest-neighbors model, accounting for multi-modality, for neutralization-induced deformations, and for changes in DNA properties related to epigenetic changes. Using these models we expect to analyze fine details of (human) genome structure and regulation, trying to reach the connection point between physical properties of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Characterisation of genetic variation in the pig breeds of china and europe to facilitate the maintenance and exploitation of biodiversity'.

assistant: **Concept**

Genetic diversity among the pig breeds of China and Europe will be evaluated. At least 50 Chinese breeds will be sampled and compared with 59 European breeds previously sampled. Breed relationships will be determined by estimating genetic distance based on micro satellite markers and heliotypic relationships from medina and Y-chromosome polymorphisms. The relationship between general measures of genetic diversity, such as genetic distance, and functional differences among breeds will be determined by characterising trait gene loci (type I markers) and QTL regions. Measures of diversity derived from anonymous markers (micro satellites) will be compared to measures derived from the trait genes. Analysis methodologies to utilise DNA marker (genetic) data for identifying genes involved in functional differences between breeds will be developed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The development of bio-supported homogeneous organocatalysts with improved recycling potential through sequential de- and re-polymerization and their use in CO2 valorization catalysis' (RECIRCULATE).

assistant: **Innovation**

The use of homogeneous catalysis is currently limited as they lack the ability to be easily recycled, and thermal deactivation of the catalyst cannot be always avoided. These features present important hurdles for the application of homogeneous catalysts in commercial processes and represents an open challenging. Designing ways to bridge the advantages properties of homogeneous and heterogeneous catalysis through the creation of supported homogeneous catalysts with well-defined active sites having high stability and recycling potential creates new incentives for circular type homogeneous catalysts with application potential in synthetic chemistry. In this project, several approaches are presented to realize this challenging goal. First, well-known N-heterocyclic bases such as TBD and DBU will be immobilized onto a biobased polycarbonate and their activity optimized in the synthesis of glycidol carbonate by a sequential catalyst testing-depolymerization-repolymerization approach. The depolymerization will be facilitated by a base catalyst, while the repolymerization will be carried out through a known procedure developed at the host laboratory. This allows to optimize and fine-tune the catalyst structure in terms of active site separation, concentration and local micro-environment. In order to be able to extend the recycling of the catalyst components to a fully recyclable system, a cross-linked version will be created and tested during an industrial secondment. A second strategy builds on a controlled copolymerization of pre-functionalized biobased monomers that feature two separate catalyst components. Their successful copolymerization and variation of their relative ratio permits the optimization of the catalytic activity of this binary system in CO2 valorization thro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Faba bean breeding for sustainable agriculture' (EUFABA).

assistant: **Innovation**

To solve the chronic lack of home produced plant protein in the EU, we propose a joint European iniciative to combine the application of marker assisted selection and conventional breeding methods to develop enhanced faba bean genotypes with characteristics of importance to sustainable agriculture. Priority will be given to the combination of increased yield, digestibility, nutritional quality and resistance to major biotic and abiotic stresses, thus allowing for the production of a leguminous crop for animal feed of high value in European crop rotations of low inputs and stable yields.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Precision Diagnostics for Predicting Therapy Response to Bispecific Antibodies'.

assistant: **Concept**

Immunotherapies have revolutionized cancer treatment by utilizing the patient's immune system, offering hope for treating a wide range of diseases. However, challenges such as therapy resistance, poor response rates, and high costs remain. Precision diagnostics that accurately identify patients likely to benefit from specific immunotherapies could optimize treatment efficacy, reduce unnecessary treatments, and significantly decrease healthcare expenses. A major limitation of current predictive biomarkers is their focus on the abundance of individual immune components, such as T cell numbers or specific surface markers, without considering the crucial interactions among immune cells or between immune and cancer cells. Such cellular interactions are particularly relevant for the efficacy of the immunotherapeutic class of bispecific antibodies, which target cancer by facilitating direct interactions between cancer and immune cells. Traditional methods for predicting response to immunotherapies fail to account for the complexity of these cellular interactions. Our ERC-Starting Grant project introduces an innovative framework for simultaneously mapping single-cell immune landscapes and cellular interactions at a low cost and ultra-high scale. Applying this approach to pre-treatment samples from children with acute lymphoblastic leukemia undergoing bispecific antibody therapy has allowed us to identify specific cellular interactions associated with therapy response or failure. Here we suggest to refine, validate and prepare the clinical implementation of our approach with the goal to develop a novel precision diagnostic tool that accurately predicts response to bispecific antibodies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Spectroscopy using optical fibers in the marine environment', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Introduction The EC has a firm commitment to monitor and maintain the health of our oceans, manifested in programmes like GOOS, HDP, MAST etc. Man made sewage brought into the sea by rivers and treatment plants is subject to rapid changes in the marine environment. These changes make it difficult to assess the processes governing the pollutants and their impact on the affected regions. Current State of the Art Conventional sampling in estuaries and coastal regions delivers accurate and comprehensive data for a series of measurement points. However, the known strong variations in concentrations, and other inherent problems render sampling methods unsuitable for the collection of the required data. What is needed for this purpose are in-situ methods. Objective and Innovative Aspects This project aims to demonstrate the feasibility of using fiber optical probes in the marine environment for in-situ measuring purposes. The measurement principles are based on well known spectroscopic methods like fluorescence, absorption, scattering and refraction. However they use innovative fiber optical chemical sensors where optic fibers deliver radiation to and from the sample and also form the sensor itself. Developments in fiber optical chemical sensors are tremendous. In addition, key components and technologies like laser diodes, CCDs and fiber technology are thus far developed to allow for this ambitious Description of Instrument The device will consist of four fiber optical sensors (optodes) linked to a core optical instrument for spectroscopic analysis. Laser diode sources and detector will be under-water with only the control unit anc data processing on board. For the demonstration stage the following currently relevant analytes will be monitored; Heavy metals: Cu, Pb and Zn, ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Biogeography and behavioral adaptations of late Quaternary hunter gatherers in the Sahara'.

assistant: **Concept**

Project BREATHE aims to contribute a new understanding of cultural and behavioral traits of North African early humans through the archaeological record of southern and northern Libya. This is a crucial region for understanding the trans-Saharan connections that contributed to the global dispersal of our species. However, the current scant archaeological and chronometric data for the Saharan and peri-Saharan regions limits our knowledge of biogeographic dynamics that linked different regions of North Africa at key moments of human biological and cultural evolution, especially around the emergence of H. sapiens ca. 300 ka. The project research areas, the Jebel Gharbi to the north and the Acacus and Messak to the south, represent the extremes of an ideal North-South transect with different environments and archaeological records, an important axis between sub-Saharan Africa and the Mediterranean. These arid regions have deeply eroded landscapes where Pleistocene geoarchaeological archives are rare. Except for few buried contexts, the evidence is mostly comprised of lithic artefacts found on open-air surfaces. Nevertheless, these surface lithics can provide a wealth of information when an array of cutting-edge analytical techniques (geospatial statistics, geometric morphometrics and wear analyses) are combined in the way proposed by BREATHE. These artefacts span the final phases of the Early Stone Age, the early emergence of the Middle Stone Age and its later manifestations, particularly the Aterian. The spatial amplitude of the research areas enables large-scale landscape analyses to be carried out, identifying land use and occupation patterns not detectable at a site-oriented research scale. This provides a unique window into past human behaviour and biogeographic dynami
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Collaboration to develop a business plan for the Centre of Agriculture and Forestry' (SMARTAgriFor) under Horizon 2020.

assistant: **Objectives**

The Portuguese national funding agency for Science and Technology - Fundação para a Ciência e a Tecnologia - proposes an investment (>45 million Euros) whose ultimate objective is to develop a new centre of excellence on Smart Agriculture and Forestry (SMARTAgriFor) by teaming with the Wageningen University and Research Centre in a long-term sustainable partnership. This centre is to become an international reference in the field, with the critical mass of competence to engage Portugal strategically in a path of innovative growth and also for global impact.Due to the strategic importance and leverage value envisaged for SMARTAgriFor, there is already strong support from important stakeholders including regional development authorities ensuring access to European structural funds. Further, 10 universities and 1 public research institute – representing the top performing organizations in the selected scientific domain in Portugal - will support FCT by helping develop SMARTAgriFor’s business plan in collaboration with WUR. This plan will demonstrate the centre’s potential value as a radical new approach to the topics in question. Through dynamic interaction with stakeholders, strategic partnerships will be established, funding secured, and commitments formalised to transfer infrastructure/ staff in exchange for a share in its ownership, ensuring its sustainability and financial autonomy in the long run.Clear choices have been made regarding SMARTAgriFor’s scientific focus and innovation strategy. Topics have been selected for maximum positive societal, economic and scientific impact, leveraging strategic advantage from the centre’s location in Portugal. International benchmarking will identify the optimum approach for SMARTAgriFor. Further, innovative management practices
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Study of the sequence determinants of protein folding'.

assistant: **Concept**

We have chosen as a model the truncated (residues 20-83) form of the chymotrypsin inhibitor-2 (CI-2), one of the shortest sequences known to adopt a stable native conformation. Which residues and combinations of side chain interactions are critical for specifying the native and stable fold of CI-2? In an attempt to answer to this question, we propose to develop a phage display and a colony screening procedures that would provide a means to select variants of CI-2 that fold from large libraries. The premise underlying the selection is that binding of CI-2 to chymotrypsin requires the protein be properly folded. We will construct two independent mutant libraries using doped oligodeoxyribonucleotides mutagenesis but holding constant the residues involved in binding. Phages corresponding to combinations of mutations that restore the CI-2 fold will be retrieved by affinity selection from a known CI-2 variant with disrupted folding. Residues critical for specifying the fold of CI-2 will be identified by randomizing the remaining scaffold" residues of CI-2 wild-type. Colonies that lose the binding activity then allow recovery of non viable scaffold sequences. The structure of folded CI-2 variants will be analysed using biophysical methods. The folding pathway of CI-2 variants will be compared to that of I CI-2. Characterization of the thermodynamics and kinetics of these mutants should yield insights into the sequence determinants of protein folding. Key words: chymotrypsin inhibitor-2, protein folding-stability, protein engineering combinatorial mutagenesis, phage display. The aim of this project is a better understanding of the relationships between protein folding and amino acid sequence by varying the sequence and examining the effect of these changes on both structure and