RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tools for the identification of anthropic Fire in low visibility contexts during the Middle Pleistocene' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The use of fire is an element that characterizes the genus homo and one of the technologies that more substantially modifies prehistoric life systems. Nevertheless, the oldest evidences of fire are often more controversial and difficult to identify. The Fire-Tools project address the habitual use of fire in two peninsular archaeological sites with indirect evidence of fire in their levels and dated between the 400-300ky: Sima del Elefante (Atapuerca, Spain) and La Cansaladeta (La Riba, Spain). This geographical and chronological range has been carefully selected: the Iberian Peninsula provides the ecological conditions (wood availability) for the use of fire throughout the Pleistocene, and the habitual use of fire is stipulated as the most accepted hypothesis during this period. Fire-Tools Project aims to apply a cross-cutting approach integrating archaeobotanical (Phytoliths) and chemical analytical (Polycyclic Aromatic Hydrocarbons) procedures in these two case studies to improve the analytical capacity to identify and characterize the pyroarchaeological record with low visibility. Furthermore, the project will create a widen and complete modern reference collection of phytoliths from woody plants, as an important analytical tool to address the pyroarchaeological record in Paleolithic sites. Additionally, the Fire-Tools project will evaluate the integration between the analysis of archaeobotanical microrremains and chemical elements with the archaeological data available from each archaeological site. The expected results of the methodological proposal seek to be of further application in other archaeological and chronocultural contexts with the presence of fire. In sum, the results of this project will allow knowing the relationship that the hominids of the Middle Pl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Glycosylation of peptide hormones and extensins from the model plant Arabidopsis thaliana and in-vitro synthesis of glycosylated peptides' to be submitted under Seventh Framework.

assistant: **Abstract**

As global food prices mount, the imperative for novel approaches to crop growth becomes evident. A recently discovered group of glycosylated peptides with hormonal characteristics has a similar impact on plant growth and environmental response as the classical phytohormones that were pivotal in the first green revolution.We aim to develop methods for the in-vitro synthesis of these hormones.Glycosylation is essential for peptide function. Identification of glycosyl transferases (GTs) acting on these peptides is a prerequisite for in-vitro synthesis. I will identify potential GTs by combining existing bioinformatic techniques and genomic data available at the host institution with proteomic data that I bring with me from my previous post-doctoral position in the US. I will also search for the last unidentified GT initiating glycosylation in a related, non-hormonal group of secreted peptides.Working with molecular biologists at the host institution, I will develop my molecular skills constructing tagged synthetic peptides and expressing these in putative GT mutants selected from the proteomic and genomic data. Working with mass spectrometry specialists I will analyse glycosylation signatures on peptides retrieved from wild type and mutant plants.Simultaneously, the fate of synthetic peptides progressing through the secretory system will be followed using protocols I developed during my time in the US and equipment that I bring with me. This will establish the distribution of GTs throughout the secretory system and act as a proof of concept for this technique in analysing modifications on other secreted proteins.Putative GTs expressed in heterologous systems with specific donor and acceptor substrates will confirm GT identity and demonstrate in-vitro synthetic capacity, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Lysosomal exocytosis of metastable proteins to control synaptic function' (LEXSYN).

assistant: **Concept**

The extreme length and small caliber of neuronal processes entail complex local regulation of protein turnover. In light of the high metabolic demand and dynamic protein exchange imposed by synaptic neurotransmission, several surveillance mechanisms should be in place to sense protein damage that will otherwise cause synaptic dysfunction. However, it is still essentially unclear how local control of the metastable proteome, whose proteins have a high copy number and are crucial for synaptic function, is accomplished in dendrites to prevent formation of toxic aggregates. My previous work suggests that neuronal activity drives lysosomal fusion with the plasma membrane and exocytotic release of supersaturated, aggregation-prone proteins. The deposition of these proteins in the interstitial space likely feeds into the glymphatic system and cleaning routines associated with the enhanced circulation of cerebrospinal fluid during sleep. Intriguingly, I could show that, the concomitant release of lysosomal proteases enables growth of spine synapses suggesting that lysosomal exocytosis might serve both, protein removal and synaptic plasticity, whereas the latter might be an inevitable consequence of the necessity for local disposal of aggregation-prone proteins.Building on my expertise in synapse biology and advanced imaging, the LEXSYN project aims to characterize the secretome of exocytotic lysosomes and to understand the consequences of dendritic lysosomal fusion for synaptic plasticity. I will decipher physiological signals regulating lysosomal exocytosis and investigate the pathological consequences of lysosomal fusion impairment, thereby assessing its relevance in neurodegenerative diseases. To achieve these ambitious goals, I will develop new tools for monitoring and mani
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Clinical validation of the CD32b biomarker on the European market' under Horizon 2020.

assistant: **Concept**

The overall objective of the proposed project is the clinical validation of a novel biomarker for B-cell malignancies. The presently most widely used anti-CD20 antibody treatment rituximab has considerably improved treatment options for patients with B-cell malignancies. However, effectiveness is limited by resistance to rituximab and reduced response on repeated treatments. Data indicates that tumor expression of CD32b is directly involved in the development of resistance to rituximab. CD32b has the potential to be used as predictive biomarker for critical clinical decisions for rituximab and related treatments, and will impact payers and patients. In addition, our company is developing a novel treatment – BI-1206 that specifically targets CD32b and significantly improves antitumor effects of rituximab alone. As such, the CD32b biomarker assay has the additional potential to become a companion diagnostic for BI-1206 and other future B-cell malignancy treatments. Our company and the affiliated research team have developed a flow cytometry assay for the detection of the CD32b receptor on tumor cells. The assay has been partially validated in a clinically relevant setting to demonstrate CD32b as a predicative biomarker of therapy response. To achieve market uptake of our technology, we aim to conduct a number of studies together with selected clinical partners in Europe. The objectives of the feasibility study are to find and contact researchers/clinicians for conducting retrospective and/or prospective studies, as well as to refine the business model for the commercialization of the biomarker assay. The intended users of our product are clinicians and therapy developers that focus on B-cell malignancies. By clinically validating a biomarker assay for B-cell malignancies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Regulation of Polycomb Complex (PRC2) during development and in diseases' (PRC2).

assistant: **Innovation**

Polycomb Group (PcG) proteins are pivotal for the specification and maintenance of cell identity by preventing inappropriate gene activation. They function mostly through the regulation of chromatin structure and, in particular, the post-translational modification of histones. Although the enzymatic activities of the main PcG complexes has been described, lots remain to be discovered in terms of how these chromatin modifying activities are regulated. Genome wide analysis uncovered genes that are targeted by PcG proteins in various model cell lines, however it still very unclear how PcG proteins are targeted to a specific set of genes depending on the cell type. Finally, PcG proteins are frequently fund deregulated in diseases among which cancer but whether the alteration of their expression is a causative event to pathologies requires further investigation.This proposal is focused on the Polycomb Repressive Complex 2 (PRC2) whose function is pivotal to the polycomb machinery. In the first two aims of this proposal, we will investigate mechanistically how transcription factors, non-coding RNAs and chromatin structure might independently or in conjunction establish the conditions conducive to gene targeting by PRC2 and regulate its activity. In the third and fourth aims of this proposal, we will investigate what is the function of PRC2 during tumorigenesis and cell reprogramming and how its function is regulated during these processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Research Social platform On Migration and Asylum' under Horizon 2020.

assistant: **Concept**

This project will achieve regular collaboration between Europe’s well-developed networks of migration researchers and stakeholders for the purpose of evidence-based policymaking. As a result, European coordination on migration will be better informed of and more responsive to the recent migration dynamics and their diverse consequences.ReSOMA aims • for sustainable and mutually beneficial relationships for researchers and stakeholders to consult and work with each other more regularly in their ongoing work to inform EU public debates• to make the EU’s platforms for policy dialogue and consultation more evidence-based• to raise new evidence-based top priorities for the EU’s policy agendaA clear collaborative structure and toolbox will enable inter-disciplinary and multi-stakeholder analysis and policy dialogue with some of the most influential EU policymakers at EU and national level. Researchers will be able to put forward their robust scientific evidence and recognised authority in their field, while stakeholders will provide their complementary expertise with on-the-ground know-how and front-line experience. They are also well-positioned to secure attention from policymakers and allies from diverse sectors of society. In this collaboration, EU think-tanks will play a bridging role to combine the academic and practical expertise. They will also work alongside them to translate their evidence into ready-to-use policy briefs, recommendations and convincing messages and framings. In the end, the project will produce activities and deliverables that are both amplifying the voice of researchers and stakeholders in EU policymaking and tailored to the needs and constraints of EU and national policymakers. With the newly created tools and relationships, the project’s partners
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Powers Ontology for Causal Models' (POCAM) targeting Horizon Europe.

assistant: **Abstract**

Multiple causal modelling techniques are employed in the applied sciences. For instance, Structural Equations Models (SEMs) are employed in genetics, econometrics and psychology; Fault Tree Analyses (FTAs) are employed in aerospace and nuclear engineering; Petri Nets are used in traffic control and integrated computational systems. Each technique has a unique way of representing causal phenomena, drawing on different data and background information. But what is it about the world that allows each of these techniques to work? And what makes each technique a representation of causal phenomena specifically? POCAM will break new ground answering these questions by determining a single, underlying causal ontology within the powers metaphysics framework. In doing so, POCAM will provide an explanation of why such varied causal modelling practices are so successful, thereby helping practitioners better conceptualise the connections among different modelling formalisms and with our pre-scientific understanding of causation in everyday life. While there have been attempts to determine an underlying ontology for SEMs there has yet to be any philosophical engagement with FTAs or Petri Nets, despite their pervasiveness in science. Moreover, current ontologies for causal models in metaphysics fail to be adequately reductive, preventing them from being truly explanatory. POCAM will therefore be pioneering in its attempt to provide a single reductive ontology of all three modelling techniques. To do so, POCAM will draw on the scientific credentials of the powers metaphysics framework. The nature of powers and their role in causation is increasingly well understood but has yet to be brought into sustained theoretical engagement with the casual modelling literature. Dr Friends unique exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'OWise for Europe - A feasibility study of a pan-European mobile app providing people with cancer with useful tools and treatment information in one easily accessible place.' under Horizon 2020.

assistant: **Concept**

Cancer is a big issue worldwide with 70% increase in incidence in the next 20 years. Around 3 million people are diagnosed with cancer in Europe annually and it costs the EU more than €126 bn/yr. To improve clinical outcomes of treatments, to reduce side-effects and to increase patients’ quality of life we need to accurately understand how patients experience cancer treatments.Px HealthCare (also called Px, which stands for Patient Experience) has developed OWise, an independently validated, mobile medical platform supporting cancer patients during treatment. OWise is a real game-changer as - its award-winning app was shown to improve both patient experience and the patient-doctor interaction - while the fully anonymised Patient Reported Outcome data (PRO) are collected and investigated using advanced data-analytics to improve oncology outcomes. As OWise is prescribed by physicians, it is the first oncology platform connecting patients, physicians and payers with the clear potential to benefit all 3 groups. OWise is a novel way for patients to be actively engaged in their treatment and receive customised medical support. It is also a new way for clinicians to receive PRO data and to adjust treatment in between hospital visits. Px’ revenue model is based on licensing insights it generates from the PRO data to health care insurers and pharmaceutical companies who have expressed their great need for it.Initially launched for breast cancer in the Netherlands and the UK, Px is now developing OWise for all cancer types and plans to employ it swiftly across Europe, preferably with the aid of all 3 Phases of the present programme. Aim of Phase 1 project is to develop of a business plan to roll-out OWise in EU countries, reaching at least 1 million EU cancer patients annually in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Ethical and Privacy-preserving Big Data platform for Supporting criminal investigations'.

assistant: **Objectives**

This proposal aims to develop an innovative and privacy-preserving decision-support system for European law enforcement authorities, leveraging advanced Big Data and AI technologies to effectively combat crimes and terrorism. The proposed system integrates Federated Learning, User and Entity Behavior Analytics (UEBA), and other Big Data and AI techniques to monitor social network data, deep and shallow web information, and police databases in a secure, collaborative, privacy-aware and ethical  manner.The primary objective is to help Law Enforcement Authorities (LEAs) fighting cybercrime and terrorism by identifying key communities and users involved in activities such as hate speech, child sexual abuse, terrorism, or drug trafficking and to use this information to better allocate police resources. PRESERVE will leverage Federated Learning, a decentralised machine learning approach that allows model training on distributed data sources while preserving data privacy. By collaborating with multiple LEAs across Europe, PRESERVE will collectively combine social network data, deep and shallow web information, and police databases to analyse large amounts of spatial and temporal data related to criminal activities to identify patterns and correlations to provide better police-resource management on critical areas.


**Keywords:** Federated Learning, UEBA, Cybercrime, AI, Data crawling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Global Glass Adornments Event Horizon in the Late Iron Age and Roman Period Frontiers (100 BC - AD 250)' (GLOBALGLASS), addressing dissemination and exploitation.

assistant: **Impact**

The project is multidisciplinary comparative research on the cross-cultural consumption of personal adornments, known as glass annulars, i.e. rigid, ring-shaped objects composed of coloured glass, used by the inhabitants of the European northwest borderland regions during the transition from the Late Iron Age to Roman period, c. 100 B.C. – A.D. 250. This project introduces the pan-European ‘glass adornments event horizon’, which signals the existence of an active multicultural community with its own forms of decorative identification in the borderland regions. It will assess the evidence for this phenomenon, firstly, in four north-western European countries: Germany, the Netherlands, Belgium, and United Kingdom, and, secondly, explore its regional ramifications, by concentrating on one area, United Kingdom, in order to understand the manifestation of this inter-cultural event in a local setting. The project combines thorough literary and museum research with scientific and hands-on experiments, and pays particular attention to engaging and disseminating the results to the wider public. It challenges long-standing perceptions related to the function and gender nature of glass adornments. It investigates the mobility of materials, artefacts and craftspeople, and reconstructs the networks of interethnic craft interaction in borderland zones. It analyses the transformative role these annulars played in the formation of inter-European and regional identities in a transitional period when new cultural forms and practices emerged in the European Northwest.