RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Intracellular antibodies' (1994-1998).

assistant: **Innovation**

Intracellular immunization refers to the use of strategies to interfere with the function of intra- or extracellular gene products in animal cells. Intracellular immunization approaches are receiving great attention for application to human gene therapy and for functional genomics, and include antisense RNA or oligonucleotides, ribozymes, dominant negative mutants. Each of these approaches suffers from drawbacks and limitations. This proposal is about applications of a new strategy for phenotypic knockout in mammalian cells: intracellular antibodies. This new strategy for intracellular immunization in animal cells, based on the ectopic expression of recombinant antibodies and their targeting to different subcellular compartments, was developed by some of the scientists involved in this project and successfully applied in a variety of systems, including animal and plant cells. The intracellular antibody approach combines the richness of the virtually unlimited repertoire of the immune system to the versatility provided by the use of intracellular targeting signals. Due to its successes, the use of cloned antibodies for intracellular immunization is likely to become a widely used strategy to inhibit the function of recognised molecules, both for scientific therapeutic and applicative purposes. The final objectives of the present proposal are to apply the intracellular antibody strategy to block the function of proteins involved in i) the afferent and efferent phases of HIV viral infection and in ii) the (dis)regulation of growth control of mammalian cells, in a perspective of developing gene therapeutical approaches for cancer and restenosis. The work will also involve the refinement and optimization of the intracellular immunization strategy. Gene therapy for the treatme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Structural International Post Doc Program 2' (SIPOD2), addressing dissemination and exploitation.

assistant: **Impact**

The SIPOD (Structured International Post Doc Program) is designed to attract excellent scientists and to boost their career as post-doctoral fellows towards becoming successful and independent group leaders. SIPOD aims to foster the incoming trans-national mobility and the reintegration of fellows. In the proposed program the Scuola Europea di Medicina Molecolare (SEMM) operated in conjunction with three major Research Centers in Lombardy: IEO (Istituto Europeo di Oncologia), FHR (Foundation Humanitas Research) and IFOM (Istituto Firc di Oncologia Molecolare).SIPOD is characterized by:1. Trans-national mobility and re-integration of fellows.2. Freedom of choice for the fellows to select the research topic and destination within the receiving Host Institutions.3. Possibility to conduct interdisciplinary research project, where fellows will have the opportunity to have joint positions on shared projects with group leaders (at least two) working in different disciplines.3. Equal Opportunities for men and women, and consideration of career breaks.4. Higher education program based on five training activities: Patenting, Tech transfer and Licensing; Grants scouting, writing and management; Team leading and Group organization; Translational Research and Clinical Trials; Ethical issues in science.This program stems from internal and external post-doctoral surveys indicating that at present the career transition from postdoctoral fellow to group leader (independent investigator) is not supported by an adequate training/educational support. SIPOD is designed to fill this gap.SEMM launched in 2009 its first Structured International Post doc program (SIPOD) under the FP7-PEOPLE- 2007-COFUND scheme. The success of SIPOD has prompted us to propose a new application that remains finan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Transformation of Organic Dyes into Advanced Materials by Chemical Vapour Deposition' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Conjugated polymers are drawing a constantly growing interest for modern energy technologies, particularly for the clean production of hydrogen fuel by visible-light photo-electrocatalytic water splitting. Although conjugated polymer catalysts are reported as stable, low cost and versatile materials, current synthetic approaches (solution-based) have prevented the study of the most interesting motifs and hindered the up-scaling of most conjugated polymers for practical applications. The central idea of the TODAM project builds on the recent achievements of the host group in the chemical vapour deposition (CVD) reaction of chromophore-based conjugated polymers, which will constitute a new field of research for the applicant. Notably, the TODAM project will combine the expertise of the applicant and the supervisor to expand far beyond the state-of-the-art of conjugated polymers while investigating the gas phase polymerisation of industrial dyes, i.e. DiketoPyrroloPyrrole (DPP) derivatives. In spite of their remarkable properties, including an exceptional light resistance and unique physicochemical properties, conjugated DPP assemblies remain a largely unexplored topic due to the lack of synthetic approaches. The broad knowledge of the applicant in organic chemistry, and more particularly his cutting-edge expertise in the field of functional dyes, will be used for the design and study of new homo- and copolymers. Finally, the scalability of the proposed CVD approach, readily forming thin films, will allow the integration of the new conjugated polymers as heterogeneous catalysts for photo-electrochemical water splitting. The formation, separation and transport of charges will be elucidated for the design and large-scale application of robust and efficient metal-free heterog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Intelligent investment analysis of early-stage companies' in the context of a Horizon 2020 call.

assistant: **Objectives**

The European startup ecosystem is booming. It has attracted more than $3.5bn of venture funding in Q3 2015, the highest in 5 years. A major factor fueling this growth is a higher-resolution venture finance industry, which has opened up the traditional Venture Capital (VC) space to new types of early-stage investors: angels, crowdfunding networks, accelerators and micro-VCs.The challenge these early-stage investors face is the lack of commercially available business intelligence tools to support the decision-making process. The high-risk nature of early-stage investing increases the odds of mis-allocating capital and is raising concerns from industry professionals and regulators alike.Crowd Analytics is a first-of-its-kind large-scale data analytics and visualisation platform that helps investors assess the risk profile and investment-readiness of early-stage companies. The system collects structured and unstructured data from a number of public and private sources, correlates them using proprietary algorithmic analysis, deduces relevant insights and presents them to the user in an intuitive and structured manner.This results in reliable, data-driven insights across the complete spectrum of early-stage investment opportunities that will be offered through a subscription service.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Big-data Earth observation Technology and Tools Enhancing Research and development'.

assistant: **Innovation**

The main objective of BETTER is to implement an EO Big Data intermediate service layer devoted to harnessing the potential of the Copernicus and Sentinel European EO data directly from the needs of the users.BETTER aims to go beyond the implementation of generic Big Data tools and incorporate those tools with user experience, expertise and resources to deliver an integrated Big Data intermediate service layer. This layer will deliver customized solutions denominated Data Pipelines for large volume EO and non-EO datasets access, retrieval, processing, analysis and visualisation. The BETTER solutions will focus in addressing the full data lifecycle needs associated with EO Big Data to bring more downstream users to the EO market and maximise exploitation of the current and future Copernicus data and information services. BETTER developments will be driven by a large number of Big Data Challenges to be set forward by the users deeply involved in addressing the Key Societal Challenges.The World Food Programme, the European Union Satellite Centre and the Swiss Federal Institute of Technology - Zurich working in the areas of Food Security, Secure Societies and GeoHazards will be the challenge promoters. During the project each promoter will introduce 9 challenges, 3 in each project year, with an additional nine brought by the “Extending the market” task, in a total of 36 challenges. The Data Pipelines will be deployed on top of a mature EO data and service support ecosystem which has been under consolidation from previous R&D activities. The ecosystem and its further development in the scope of BETTER rely on the experience and versatility of the consortium team responsible for service/tool development from DEIMOS and Terradue. This is complemented by Fraunhofer Institute’s e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The functional significance of soluble amyloid beta (Abeta) oligomers for learning and memory deficits in Alzheimer's disease' under Seventh Framework.

assistant: **Concept**

Alzheimer’s disease (AD) is characterised by a gradual cognitive decline, which initially affects learning and memory, and gradually impairs other cognitive functions. Despite considerable scientific effort, the cause and pathogenesis of AD is still unknown. Recent in vitro studies suggest that the destruction of synapses by soluble aggregates of amyloid beta (Abeta) might play a role in mediating the progression of the disease. However, what is lacking is an approach that establishes the links between cellular pathology, its causative effect on neuronal network activity in the affected brain areas, and the resulting behavioural impairments. This project aims to address this shortcoming by using a cross-disciplinary design. Core to this project are novel transgenic mice overexpressing soluble (Abeta), which will be tested on object and spatial recognition memory tasks. A novel imaging technique, manganese-enhanced MRI, will be used to establish the effect that soluble (Abeta) has on neuronal activity in the perirhinal cortex and hippocampus, brain areas that are affected early in AD and mediate these types of memory. Lastly, we aim to investigate whether memory deficits in arc(Abeta) mice can be abolished by inhibitors that target elements of (Abeta)-activated signalling cascades recently established in vitro. This will be achieved by direct infusion of drugs into the brain regions of interest in freely behaving arc(Abeta) mice, with the aim of identifying new targets for pharmacotherapeutic intervention. The fellowship at the Max-Planck-Institute for Psychiatry in Munich will enable the applicant, who has received excellent training in the basic field of learning and memory at Oxford and Cambridge, to acquire additional competencies focused on the neuroscience of neuro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'CONSTRUCTION OF SHP GUNZESRIED WITH A PRESSURE PIPE KAPLAN-S TUBE TURBINE WITH 6 BLADE RUNNER'.

assistant: **Objectives**

The project aim is to demonstrate the new construction of a low head run-of-river hydro scheme at Gunzesried/Aubach equipped with a novel Pressure-Pipe Kaplan-S-Tube Turbine with a six-Blade runner. Special attention is paid to the arrangement of the plant outside of a narrow gorge, using a penstock with a lenght of some 100 m, concentrating the relatively high head (12 m) in front of the turbine. With specially developed runner geometry the turbine generator set displays a very flexible solution for this special application.Technical data: number of turbines = l, net head = 12,0 m, rated discharge = 4 m3/s, max. capacity = 398 kW.Estimated total annual energy production: 1 363 000 kWh.- First application of a 6-blade pressure pipe Kaplan-S-Turbine concerning the head of 12 m and a widely varying flow up to 4 m3/s.- Specially developed runner geometry adapted to the given head and flow as well as to the arrangement of the turbine generator set.- Improved overall efficiencies by direct coupling of turbine and generator. - Bearing of guide vane and runner blades with oil-free lubrication.- Specially developed guide vane assembly to minimize silt infiltration and abrasion of turbine runner.- Coated suction tube for improving noise reduction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Gene therapy for the treatment of philadelphia-positive acute leukaemia' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

We have created a three finger peptide able to target specifically the pl90BCR-ABL oncogene. The purpose of this project will be to develop a procedure in which the molecules that can interfere specifically with oncogene activity (ie. anti p190BCR-ABL peptide in our case) is co-introduced to the targeted cells (murine haematopoietic pro-B Ba/F3 cell lines expressing the pl90BCR-ABL oncogene and bone marrow cells derived from pl90BCR-ABL transgenic mice) via such vectors as viruses which encode a selectable cell surface expression marker (truncated human CD5 in our case). The targeted cells expressing the surface marker are completely separated from untargeted cells by sorting techniques for transfer back into the recipient. We hope that this gene therapy based approach will facilitate the development of a novel and curative treatment for Ph l-positive human leukaemias.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Environmental justice and inequality in Europe'.

assistant: **Concept**

The US Environmental Protection Agency (EPA) defines environmental justice (EJ) as the fair treatment for people of all races, cultures, and incomes, regarding the development of environmental laws, regulations, and policies. EJ policies are intended to overcome environmental inequalities caused by racial and economic advantages built into policy-making, enforcement, and locating of waste disposal and polluting industries. Most research on Environmental Justice demonstrates that there are disparities by race and class in the distribution of environmental hazards, whether defined by facility location, emissions, ambient concentrations of air pollution, or environmental enforcement and clean-up activities. Environmental justice is a relatively unexplored but growing policy area in Europe. There are a number of European laws and directives that specifically relate to developing access to environmental information, participation and decision- making.Environmental Justice may offer new insights into the juncture of social inequality and public health in Europe and may provide a framework for EU policy discussions on the impact of discrimination on the environmental health of diverse communities. Within the present research project we aim at quantifying the concept of environmental justice for Europe. In our analysis we will analyse the issue of environmental equity linked mainly to three sets of variables: variables linked to economic welfare, variables linked to environmental stress, and variables connected with public health. The analyses will investigate the distribution of environmental costs amongst different demographic groups (i.e. low income, ethnical minorities) in Europe, with a focus on the Netherlands and Italy. Due to the spatial nature of our socio-economical d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Assessing infiltration and exfiltration on the performance of urban sewer systems (APUSS)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Sewer systems constitute a very significant patrimony in European cities. Their structural quality and functional efficiency are key parameters to guarantee the transfer of domestic and trade wastewater to treatment plants without infiltration nor exfiltration. Infiltration of groundwater is particularly detrimental to treatment plant efficiency, while exfiltration of wastewater can lead to groundwater contamination. Both problems are critical on a long-term basis for sustainable urban water management. This research project, associating universities, SMEs and municipalities in 7 European countries, will develop new methods and techniques to assess and quantify infiltration and exfiltration in sewer systems. The methods will be tested and validated in different catchments. Associated models and tools will be proposed for scaling up and for application and end-user decision support.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Coupled climate and Greenland ice sheet evolution:past, present and future' (CoupledIceClim) targeting Horizon 2020.

assistant: **Abstract**

The Greenland ice sheet (GrIS) is losing mass at an increasing pace, in response to atmospheric and ocean forcing. The mechanisms leading to the observed mass loss are poorly understood. It is not clear whether the current trends will be sustained into the future, and how they are affected by regional and global climate variability. In addition, the impacts of Greenland deglaciation on the local and global climate are not well known. This project aims to explain the relationship between GrIS surface melt trends and climate variability, to determine the timing and impacts of multi-century deglaciation of Greenland, and to explain the relationship between ongoing and previous deglaciations during the last interglacial and the Holocene. For this purpose, we will use the Community Earth System Model (CESM), the first full-complexity global climate model to include interactive ice sheet flow and a realistic and physical-based simulation of surface mass balance (the difference between surface accumulation and losses from runoff and sublimation).  This tool will include for the first time a large range of temporal and spatial scales of ice sheet-climate interaction in the same model. Previous work has been done with oversimplified and/or uncoupled representations of ice sheet and climate processes, for instance with simplified ocean and/or atmospheric dynamics in Earth System Models of Intermediate Complexity, with fixed topography and prescribed ocean components in Regional Climate Models, or with highly parameterized snow albedo and/or melt schemes in General Circulation Models. This project will provide new insights into the coupling between the GrIS and climate change, will lead widespread integration of ice sheets as a new and indispensable component of complex Earth Syst