RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how '3D Printing of Ultra-fideLity tissues using Space for anti-ageing solutions on Earth' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Bioprinting in Space is one of the novel promising and perspective research directions in the rapidly emerging field of biofabrication. There are several advantages of bioprinting in Space. First, under the conditions of microgravity, it is possible to bioprint constructs employing more fluidic channels and, thus, more biocompatible bio-inks. Second, microgravity conditions enable 3D bioprinting of tissue and organ constructs of more complex geometries with voids, cavities, and tunnels. Third, a novel scaffold-free, label-free, and nozzle-free technology based on multi-levitation principles can be implemented under the condition of microgravity. The ideal Space bioprinters must be safe, automated, compact, and user friendly. Thus, there are no doubts that systematic exploration of 3D bioprinting in Space will advance biofabrication and bioprinting technology per se. Vice versa 3D bioprinted tissues could be used to study pathophysiological biological phenomena when exposed to microgravity and cosmic radiation that will be useful on Earth to understand ageing conditioning of tissues, and in space for the crew of deep space manned missions. In PULSE, we aim at developing a radical new bioprinting technology based on multiple levitation principles and to use Space as an accelerator of ageing on Earth. As a proof of concept study, we will use this newly developed bioprinting technology to create cardiac 3D in vitro models able to better mimic cardiac physiology compared to organoids. We will use such models to study cardiac ageing and test the efficacy of antiinflammatory/ anti-oxidative drugs with anti-ageing potential.


**Keywords:** biofabrication; levitation; bioassembly; 3D in vitro models; cardiac biology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression'.

assistant: **Objectives**

Type 2 diabetes (T2DM) is preventable by sustained changes in diet and physical exercise. Despite this, modern societies are already approaching 10% population prevalence of diabetes, and another 15% with pre-diabetes. The costs of T2DM are huge, approaching 10% of all health costs.  Prevention of diabetes is a priority for national healthcare agencies and for the health insurance industry.  Investment in prevention and lifestyle programmes requires a solid evidence-base for targeting and customising these interventions in a cost-effective manner. Translation of the findings from T2DM prevention studies to the benefit of general public health has not yet been possible.DEXLIFE will identify novel diagnostic and predictive biomarkers (i) to detect the progression toward diabetes in high risk individuals and (ii) that are responsive to lifestyle interventions known to be effective in diabetes prevention. New biomarkers alone will be insufficient to alter the course of diabetes progression. We bring a strong translational focus to this proposal, by setting the main intervention in the real-life context of a major health insurance system. The accumulated phenotyping repertoire from an extensive panel of –omic analyses will be refined and modelled into a new diagnostic panel for the allocation of high risk subjects to individualised preventive regimens.Our multi-disciplinary team has a strong track record in clinical diabetes and metabolism.  Several unique clinical cohorts will provide the basis for a series of clinical, physiological and mechanistic investigations, which will identify, monitor and analyse the impact of biomarkers over time.  An exercise and dietary intervention study will be included in two specific cohorts, enabling us to assess the impact of such interven
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Control of CBP functions by calcium signalling pathways in neurons' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The aim of this work is to determine molecular domains and phosphorylation sites involved in the regulation of CBP transactivating properties upon Ca(2+) stimulation in neuronal cells. I will also assess the role of CBP's histone acetyl transferase activity in Ca(2+-)activated gene expression.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Combining smart card and local operating network technologies with advanced decision support techniques to develop an intelligent industrial energy management system for buildings' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The BUILTECH research programmeaims to develop, test and document an integrated global building energy management system combining intelligent decision making systems, (DMS), and smart card techniques and based on recent local operating network, (LON), technology which is suitable for existing buildings equipped with conventional energy facilities, as well as for new buildings without construction modifications. The proposal describes an interrelated set of research actions under the following specific objectives: 1. To develop near optimal decision support algorithms by making use of an advanced fuzzy logic generic method to obtain rules adapted to the building automation demands. 2. To combine smart card for access control of energy equipment and fuzzy techniques with very recent local operating network technology for data transmission in order to develop an advanced, easy to install and operate hardware configuration designed especially for existing buildings, but also easy to incorporate in new buildings. 3. To study appropriate techniques that will combine and use the developed smart control system with conventional HVAC and building equipment as installed in existing buildings and not only with new technologies to be installed in new 4. To test with appropriate experimental actions the potential of the developed system for energy conservation in existing as well as new buildings. 5. To integrate the results of the programmeinto a set of guidelines for efficient facilities management in buildings to be used by designers, developers and building management systems and contribute to the reduction of the energy consumption by up to 25 per cent compared to a conventional control system. The final products of the present research will be the following: 1. A fully tested
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nature, Technology and Design' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The NATEDE project is a breakthrough indoor air-cleaning technology targeting not just the elimination of indoor air pollutionbut also the creation of healthy new air thanks to a powerful combination of real plants with technology and design (Clairysolution). The novelty of the NATEDE project is based on the introduction of the forced-air system in the natural airpurification arena. It is done through the introduction of a specially designed pot equipped with a fan forcing the air to movethrough the soil and the roots of the plant by stimulating faster and more effectively the process of elimination of pollutionand the process of photosynthesis. Moreover, the NATEDE project introduces a mobile internet functionality (in line with theInternet of Things trend) combined with a set of advanced sensors to the equation, whereby users can operate the Clairysolution through their smartphones and tablets, set automatic start/stop time based on predefined parameters (time, level ofair pollution, etc.) and monitor the actual indoor pollution. The proof of concept has already been achieved showing that theClairy solution can reduce indoor pollution to safe levels already within hours of activity. Consequently, Clairy can beconsidered as one-of-a-kind solution that gives an “extra pair of lungs” to plants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Viability verification and market launch preparations for outdoor electronic message board displays' to be submitted under Seventh Framework.

assistant: **Abstract**

The aim of the E-Signage Demo project is to explore the market potential and prepare the market launch of a widely usable outdoor electronic signage and message board (OEMB) display module based on a fundamentally new display technology in combination with transparent electrode front-plane layers. As an example, the OEMB display module can integrated into OEMB device that consists of a display module, power supply i.e. a solar cell system, GPRS modules, software, and is used for transmitting visual information.The demo-project draws on the outcomes of a successful FP7 project E-SIGNAGE  (Nov. 2011- April 2013) where the partners developed a low-cost, durable, high brightness and contrast level, energy efficient (bi-stable; no backlight needed), high information content two colour electronic outdoor message board device that is able to receive data via GSM communication and uses solar energy as a power source. However, usage possibilities of the display module that was developed as a part of the OEMB device under E-SIGNAGE are not limited with the original OEMB device structure. Therefore in order to have a wider applications possibility and through this a wider impact on the SME participants / overall market, current project partners are focusing on exploring its extended market potential. This exploration will be followed up by viability verification and market launch preparation activities for reducing the gap between the OEMB display module developed by E-SIGNAGE and the market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Fabrication and architecture of single electron memories' (FASEM) under Fourth Framework.

assistant: **Objectives**

Our long term objectives are :- to develop high resolution nanofabrication of coupled islands for single electron electronics, with potential for mass fabrication .- to form a sound basis and pave the way for new generations of solid-state memories with terabit storage capacity, with appropriate access speed and full compatibility with mainstream silicon technologyThe objectives of the FASEM programme were to develop techniques for the high-resolution nanofabrication of coupled islands for single-electron devices and to use this technology as a basis for a new generation of silicon-compatible solid-state memories with terabit potential.The consortium has invented a silicon-based single-electron memory cell: the Lateral Single-Electron Memory (L-SEM). The L-SEM can be used to fabricate a fast, random-access memory with the potential for large-scale integration. The L-SEM cell uses a single-electron device coupled to a conventional MOSFET. The cell has been fabricated in crystalline silicon-on-insulator (SOI) material using a heavily-doped, side-gated silicon nanowire single-electron transistor (SET). Typically, the SET silicon nanowire cross-sectional area is less than ~40 nm (40 nm. The cell has been operated with detectable storage of small electron numbers (~60 electrons on a 1 µm (70 nm area memory node). The write/erase time of the cell is 10 ns and the cell can operate successfully at temperatures up to circa 50 K. The crystalline silicon-on-insulator L-SEM cell has been integrated into a small 3 (3 bit memory array. Full functional operation of the memory has been demonstrated, including the read/write timing cycle and cell selection without data corruption.The side-gated silicon nanowire SET has also been fabricated in polycrystalline silicon films, but not yet i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SECURITY BY DESIGN IOT DEVELOPMENT AND CERTIFICATE FRAMEWORK WITH FRONT-END ACCESS CONTROL' (IOTAC), addressing dissemination and exploitation.

assistant: **Impact**

IoTAC project aims to deliver a novel, secure and privacy-friendly IoT architecture that will facilitate the development and operation of more resilient IoT service environments through (i) monitoring and evaluation of applications security throughout the broader software development lifecycle; (ii) the introduction of an advanced access control mechanism based on new interactions and workflow using chip card and PKI technology; (iii) the runtime monitoring of the system as well as provisioning of security countermeasures that are implemented both at hardware- and at software-level and (iv) associated platforms which will provide security certification of the produced applications and system, based on international security standards, best practices and the research results of the project. The results will be demonstrated (TRL5) with four IoT use case implementations. The consortium comprises all stakeholders of the IoT ecosystem, service operators, OEMs, technology providers, developers, security experts, as well as research and academic partners. The end users will be involved by using a living lab environment. Objectives of the project will be fostered by a strong dissemination and communication program also comprising standardisation and community building, supporting the commercial and scientific exploitation of the results.


**Keywords:** IoT, Access control, Certification, Security by design, Privacy, Data protection, Accountability, Chip card, PKI, new operating model, standard architecture, performance measurement, threat detection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The regulation of SHP-1 tyrosine phosphatase in B cell antigen receptor signaling' to be submitted under Sixth Framework.

assistant: **Abstract**

Antigen specific activation of B cells is mediated by the B cell receptor complex (BCR). Signal transduction of this receptor is regulated by the equilibrium of kinase and phosphatase activity. Syk protein tyrosine kinase and Src homology 2 domain containing protein tyrosine phosphatase 1 (SHP-1) has prominent role in the establishment of this equilibrium.The aim of this proposal is to study the regulation of SHP-1 function. SHP-2 belongs to the same family of phosphatases, have high structural and sequence homology to SHP-1 but in contrast play mostly positive regulatory role in cell functions. The main goal of the project is to identify the modifications; molecular interactions that control the activity and intracellular localization of these enzymes and to compare the mechanisms of their regulations.The major sequence differences of these phosphatases are in their C-terminal tail and probably this part is responsible for their functional divergence. This part of the protein contains two tyrosine and one-serine residues in SHP-1 and also two tyrosines and two serines in SHP-2. These amino acids are phosphorylation targets. My goal is to identify the kinase/kinases that phosphorylates them and other interacting molecules that can bind them and may regulate the phosphatases. For this purpose I will use the S2 Schneider cell reconstitution method that was developed in the host laboratory.By the inducible and transient co-transfection of signalling molecules this method allows the rebuilding of signalling pathways in an evolutionary distant system and also to exclude the redundancy that is typical for molecules in mammalian signalling networks. SHP1 deficiency can lead to autoimmunity therefore revealing the molecular mechanisms of the regulation of this phosphata se may
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Process optimization of laser welding for industrial application by on-line-control and evaluation' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The aim of the project is the development of a modular designed on line control system for laser welding as a tool for high quality production. Based on technologies of thermal, optical and ultrasonic intererometric probes the sensors and the controller unit will be developed. Depending on the welding application and the quality demands for the processed workpieces one or a couple of different noncontact sensor devices will be used for sensing the welding process. By successful completion of the work programme the following effects are expected:  Realisation of a pre industrial prototype to obtain real time" data access to the weld quality allowing an on line monitoring of the welding process for assuring the workpiece quality.  Realisation at a laboratory scale of an on line control system with a closed loop interaction to the laser welding process, e.g. through the laser power, the welding speed, the focal position or other actuators.  Analysis of requirements of various applications, not realised in this project, to the performance of the control system to assure a wide dissemination of the modular system.  Integration of the modular on line control system into production lines to reach a better quality and increase the production efficiency in terms of less scrap, less energy consumption, less crude materials input and reduced production time. Beginning the work of the project with evaluate the industrial values for welding quality and the constraints to the welding process for given applications of the project partners, a correlation between welding process parameter and occurring defects will be done by theoretical modelling and experimentals. Out of given non contact sensors (optical, thermal, ultrasonic) usable sensors will be selected and developed on. With the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Bio-inspired Design of Catalysts for Selective Oxidations of C-H and C=C Bonds'.

assistant: **Concept**

The selective functionalization of C-H and C=C bonds remains a formidable unsolved problem, owing to their inert nature. Novel alkane and alkene oxidation reactions exhibiting good and/or unprecedented selectivities will have a big impact on bulk and fine chemistry by opening novel methodologies that will allow removal of protection-deprotection sequences, thus streamlining synthetic strategies. These goals are targeted in this project via design of iron and manganese catalysts inspired by structural elements of the active site of non-heme enzymes of the Rieske Dioxygenase family. Selectivity is pursued via rational design of catalysts that will exploit substrate recognition-exclusion phenomena, and control over proton and electron affinity of the active species. Moreover, these catalysts will employ H2O2 as oxidant, and will operate under mild conditions (pressure and temperature). The fundamental mechanistic aspects of the catalytic reactions, and the species implicated in C-H and C=C oxidation events will also be studied with the aim of building on the necessary knowledge to design future generations of catalysts, and provide models to understand the chemistry taking place in non-heme iron and manganese-dependent oxygenases.