RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sea-level change due to climate change' (SEACHANGE), addressing dissemination and exploitation.

assistant: **Impact**

Sea-level rise as a consequence of climate change will have severe impacts on coastal populations and ecosystems. However, owing to the incomplete state of scientific knowledge, there is a large range of uncertainty in the predictions, of a factor of more than two for any given emissions scenario during the 21st century, and much larger for subsequent centuries. This is a serious obstacle to the assessment of impacts. Sea-level change is a diagnostic of a complex combination of Earth system processes operating over a wide range of timescales. Explaining the record of past sea-level change and predicting the future is therefore a fascinating interdisciplinary scientific challenge as well as one with practical implications. The aim of this project is to improve quantitative understanding and hence reduce uncertainty in predictive models of the two main climate-related contributions to sea-level change, namely ocean density change and changes in ice-sheets. The former is the most important term on timescales of years to centuries, and the latter is the principal influence over timescales of centuries to millennia. In both parts of the proposal, our focus is on analysis of changes simulated by 3D atmosphere-ocean climate models, which we compare with observational data. For ocean density change, the objectives are to analyse the physical processes responsible for global-mean and local sea-level change due to density change, in order to quantify and constrain the uncertainties in predictions. For ice-sheets, the objectives are to increase our understanding of and ability to model the coupled evolution of ice-sheets and climate on multi-millennial timescales, in particular regarding the last glacial cycle and the long-term future of the Greenland ice-sheet.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Data-driven, Integrated, Syncromodal, Collaborative and Optimised urban freight meta model for a new generation of urban logistics and planning with data sharing at European Living Labs'.

assistant: **Objectives**

DISCO will develop and demonstrate - in real-life conditions - a federated European urban freight (UF) data space as one stop shop of data sharing on digital urban logistics solutions and smart tools for ambitious decision making. It will be a continental Ten-T – oriented and distributed real-life ecosystem to prove its value via demonstrated and replicable Use Cases (UCs), build upon innovation drivers to code concrete transformation of urban planning and land use by an open and collaborative UF Data Space with a smart governance model.The DISCO UF Data Space is voluntary based (incentivized), co-created and open framework to achieve a radical transformation and alliance in purpose-oriented data sharing, enabling smart access, fast and resource efficient acquisition, and focused provision, improving knowledge and capacity of city authorities and planners guaranteeing future data availability for dynamic (and predictive) integrated urban logistics planning, synchronizing real-time demand for transport & warehousing with logistics supply, (e.g., as Uber matches the demand for private car transport service with its road drivers’ fleet).DISCO will support European urban logistics players in reducing economic, societal and technical dependence from private digital platforms owned by large global providers, magnifying the scope of a Sustainable Urban Mobility Plans (SUMPs) converging to data-driven Sustainable Urban Logistics Planning (SULPs), expanding them beyond traditional urban boundaries (e.g., rural areas, towns and suburbs, cities, and urban areas according to World Urbanization Prospects ) and beyond Covid-19, to optimally manage, monitor and dynamically predict city freight flows, changing urban nodes accessibility by properly serving Functional Urban Area - FUA on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Development of a biodegradable scaffold for dermo-epidermal skin grafts'.

assistant: **Objectives**

Da nord a sud freddo, neve e temperature sotto lo zero: una donna morta assiderata in Val Venosta. Nella notte una formazione ghiacciata si è abbattuta sul tetto di una casa sfondandolo, nessun ferito.A major unresolved clinical problem in wound care is the possibility of providing an adequate coverage to severely burned patients thus enabling an efficient restoration, under both a functional and a cosmetic point of view, of the injured sites. A more widespread pathology in the wound healing area is the treatment of non healing ulcers, essentially, venous stasis ulcers and pressure ulcers. More than 1% of the total worldwide population is affected by leg ulcers: more than half of these ulcers tabe longer than 9 months to heal. Although the number of sophisticated dressings available on the market is dramatically increasing, the rate of sucess in the use of such dressings for critical lesions, where healing is impaired, is generally quite limited. There is therefore a growing demand for improved treatments that will help heal problematic wounds. Cultured keratinocytes grafting is now established as a treatment option in severe burned patients and has a place in the clinical management of other wounds, particularly chronic venous ulcers. The principal drawbacks associated with the production of cultured keratinocyte grafts and with their use in the burn scenario are the fragility and the difficulty to handle the cultured layer and, more important, the limited take rate on the wound bed and the excessive scarring and wound contraction associated with the grafting. The high costs of keratinocyte culture limit its routine use in more widespread pathologies such as chronic ulcers, despite excellent clinical results. The present proposal involves the production of an innovativ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'TELEWORK EUROPA' (TWEUROPA).

assistant: **Concept**

The aim of TWEUROPA is to revitalize opportunities in business and other professional initiatives through suitable information measures and the take-up of applications from the Telematics Applications Programme. It will prepare and disseminate materials, including library files, for key Programme sectors, participating in the activities of other projects as appropriate. In addition, TWEUROPA will launch training conferences and similar events to heighten awareness of electronic media, prepare training manuals and provide free telematics advice to interested users. Diversified expansion of the service into other European on-line networks will also be investigated.The long-term objective of TWEUROPA is the enhancement of economic opportunities, by the timely dissemination of accurate information, and by encouraging the uptake of telematics applications from within the Telematics Applications Programme and elsewhere. It is centred in the Telematic Applications Programme and will support, through the operation of one or more electronic fora, the programme's Dissemination and Concertation Mechanisms. In particular it will focus on:Dissemination activities: To prepare and disseminate suitable materials, including library files, messaging and conference sections for major sectors of the Telematics Applications Programme, and participate in relevant activities organised by other projects.Concertation & Training activities: To organise or host a number of virtual ( electronic ) awareness and training conferences and workshops, to author necessary training manuals for cascade training, to continue to provide free telematics advice to interested users, and to participate in relevant activities organised by other projects.Diversification activities: To investigate the expansion of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'KNOWING FROM THE INSIDE: ANTHROPOLOGY, ART, ARCHITECTURE AND DESIGN""' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This project promises to reconfigure the relation between the practice of academic inquiry in the human sciences and the knowledge to which it gives rise. Conventional research protocols expect the scholar to treat the world as reserve from which to draw empirical material for subsequent interpretation in light of appropriate theory. Against this, we will establish and trial an alternative procedure whereby theory is not applied after the fact, to a corpus of material already gathered, but rather grows from our direct, practical and observational engagements with the stuff of the dwelt-in world. Theoretical thinking, then, is embedded in observational practice, or knowing in being, rather than vice versa. This way of knowing, by studying with things or people instead of making studies of them, has long been key to anthropology. It is also, however, central to arts practice, as it is to the contingent disciplines of architecture and design. All four disciplines offer paths to knowing-in-being which challenge the division between data gathering and theory building that underwrites normal science. By bringing them together, this project will customise this general approach to knowing to specific contexts of practice including landscape management, craft heritage, environmental conservation, building and restoration, drawing and notation. Our method will be distinguished by observation and experiment, the outcomes of which will be not just written texts but works of art or craft, performances and installations. The project will contribute to both education and design for sustainable living through a renewed emphasis on the improvisational creativity and perceptual acuity of practitioners. It will promote the dissemination of knowledge through shared experience, and advance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Studying the gas around galaxies with the Multi Unit Spectroscopic Explorer and hydrodynamical simulations' in the context of a Seventh Framework call.

assistant: **Objectives**

Gas accretion and galactic winds are two of the most important and poorly understood ingredients of models for the formation and evolution of galaxies. We propose to take advantage of two unique opportunities to embark on a multi-disciplinary program to advance our understanding of the circumgalactic medium (CGM).We will use MUSE, a massive optical integral field spectrograph that we helped to develop and that will be commissioned on the VLT in 2012, to study the CGM in both absorption and emission. We will use 200 hours of guaranteed time to carry out deep redshift surveys of fields centred on bright z≈3.5 and z≈5 QSOs. This will yield hundreds of faint galaxies (mainly Lyα emitters) within 250 kpc of the lines of sight to the background QSOs, an order of magnitude increase compared to the best existing sample (bright, z≈2.3 galaxies). This will allow us to map the CGM in absorption in 3-D using HI and metal lines and to identify, for the first time, the counterparts to most metal absorbers.  MUSE will also enable us to detect Lyα emission from the denser CGM (also using another 300 hours of guaranteed time targeting deep HST fields) and thus to directly explore its connection with galaxies and QSO absorbers.We will use the new supercomputer of the Virgo consortium to carry out cosmological hydro simulations that contain 1-2 orders of magnitude more resolution elements than the largest existing (spatially adaptive) runs. We will use the results of our previous work to guide our choice of parameters in order to obtain a better match to the observed mass function of galaxies. In parallel, we will carry out a complementary program of zoomed simulations of individual galaxies. These will have the physics and resolution to include a cold gas phase and hence to bypass much o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Topotronic multi-dimensional spin Hall nano-oscillator networks' (TOPSPIN).

assistant: **Innovation**

TOPSPIN will focus on spin Hall nano-oscillators (SHNOs), which are nano-sized, ultra-tunable, and CMOS compatible spin wave based microwave oscillators. TOPSPIN will push the boundaries of SHNO lithography, frequency, speed, and power consumption by combining topological insulators, having record high spin Hall efficiencies, with materials having ultra-high spin wave frequencies. TOPSPIN will reduce the required current densities 1-2 orders of magnitude compared to state-of-the-art, making SHNO operating currents approach 1 uA, and increase the SHNO operating frequencies an order of magnitude to as high as 300 GHz. TOPSPIN will use mutually synchronized SHNOs to achieve orders of magnitude higher signal coherence and achieve novel functionality such as pattern matching and neuromorphic computing. TOPSPIN will demonstrate mutual synchronization of up to 1,000 SHNOs in chains, and as many as 1,000,000 SHNOs in very large-scale two-dimensional arrays. Using dipolar coupling between SHNOs fabricated on top of each other, three-dimensional mutual synchronization will also be demonstrated. As the signal coherence increases linearly with the number of mutually synchronized SHNOs the oscillator quality factor will improve by many orders of magnitude. TOPSPIN will also develop such arrays using magnetic tunnel junction stacks thus combining ultra-high coherence with the highest possible microwave output power.TOPSPIN will demonstrate ultrafast pattern matching and neuromorphic computing using its SHNO networks. It will functionalize SHNOs to exhibit ultra-fast individual voltage controlled tuning and non-volatile tuning of both the SHNO frequency and the inter-SHNO coupling. TOPSPIN will characterize its SHNOs using novel methods and techniques such as multichannel electrical m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Process integration for rapid implementation of sustainable innovative food processing' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The main objective of i³-Food is the implementation of 3 prioritised innovative food processing technologies by validation of optimum process control under industrial conditions: 1. Pulsed Electric Field preservation (PEF-P) of liquid food products (TRL 7-8); 2.High pressure thermal sterilization (HPTS) (TRL 6-7) and 3. Low shear extrusion of cold food products (TRL 6). A congeneric set of both technical (missing online sensors) and process conditioned bottlenecks (missing application of HACCP concept) does exist which hinders their uptake by industry and in the market. Therefore, optimum process control will be achieved in i³-Food leading to application under real life operating conditions by demonstrating and piloting in a near to operational environment of applicable validation systems for each technology. 6 well selected industry partners, thereof 4 SMEs, strongly support the approach and contribute as technology provider or technology applicant. For rapid and easy market uptake an analysis of the innovation environment and identification of opportunities will be performed (phase 1) as well as road-mapping for market penetration per technology (phase 2). This integrated approach will provide maximal synergies in between the 3 technologies. Application opportunities beyond the known use cases will be explored. A scientific and cutting edge strategy for overcoming the market barriers ensuring rapid and maximum market uptake will be defined. A clear description of possible applications and potential benefits will serve as an excellent basis for the dissemination activities. i³-Food will extremely benefit from results of national, trans-national and European projects. S&T project partners of i³-Food have outstanding expertise in the field of PEF, high pressure and extru
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Diversity of MHC/peptide complexes in thymic compartments and their role in shaping T cell repertoire'.

assistant: **Innovation**

Impaired selection of a functional and self-tolerant T cell repertoire is an underlying cause for development of immune system related disorders: immune-deficiencies and autoimmunity. However, current knowledge fails to explain how seemingly the same self-MHC/peptide complexes mediate the processes with completely different outcomes: survival versus apoptosis of T cells. In line, the nature of MHC/peptide complexes that mediate development of immune system and the influence of different antigen processing pathways on these complexes remain unresolved issues. The limitations of available technologies have left this question open. Recent advancement in the field of proteomics allows us now to precisely identify naturally occurring peptides that mediate selection of T cells. In addition, gene replacement technologies will be used to address the role of cathepsins, antigen-processing enzymes, on development of a fully functional T cell repertoire on one hand, and their effect on the quality and/or quantity of peptide epitopes displayed by cells that mediate T cell selection, on the other. The integration of proteomic methodology with in vivo experimental approach will enable us for the first time to interconnect the knowledge gained on cellular processes with direct physiological consequences in live animals. These new insights can accelerate not only discoveries related to T cell development, but are also relevant for understanding the interplay between T cells and pathogens, and can pave the way for new design and development of vaccines against infection diseases and therapies to treat autoimmunity. Thus, it directly contributes to strengthening European excellence in biomedical research. The host laboratory is one of the leading laboratories in the field of T cell biolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Microtubule organizing centers and microtubule nucleation in mitosis' to be submitted under Seventh Framework.

assistant: **Abstract**

Centrosomes are multifunctional organelles crucial for a large number of cellular functions including the organization of microtubules. In mitosis centrosomes contribute to assembly, orientation and function of the mitotic spindle, which is important for proper segregation of the chromosomes. Defects in centrosome number and function are strongly associated with the cancer phenotype and centrosomes offer potential new targets for anti-mitotic cancer drugs. Recent data suggests that microtubule organization at centrosomes also has implications for aspects of cellular differentiation, and that several human genetic diseases can be linked to centrosome malfunction. The characterization of proteins required for the function of the centrosome as a microtubule organizing center (MTOC) might reveal how structural and functional centrosome aberrations affect genomic stability and cancer development as well as developmental processes. I will study a key component of the centrosome and other MTOCs, the gamma-tubulin complex, and identify and characterize additional centrosome proteins involved in microtubule organization. I propose to: 1) analyze the mitosis-specific function and regulation of gamma-tubulin and associated proteins, 2) reconstitute the centrosomal attachment and function of the gamma-tubulin complex in a purified system in vitro, and 3) test proteins of the centrosome proteome for localization to a non-centrosomal microtubule organizing center, to identify and characterize those centrosome proteins specifically involved in microtubule organization.