RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Pollution monitoring in the nairobi river : application of new and robust biosensor technologies adapted to locally available resources' under Fifth Framework.

assistant: **Concept**

Most communities living in slum areas along Nairobi river and Nakivumbu wetland use untreated water for drinking and for domestic activities. Pesticide residues, pathogenic bacteria, and heavy metals are thus a major health concern. Present day assessment of contamination relies on culture methods and chemical analysis despite low reliability for detection of bacteria and their pathogenicity. It is our objective to develop and adapt molecular based methods to identify and quantify pesticide residues and pathogenic bacteria directly in given environmental water samples and to assess the state of health. We will combine phage antibody technology, 16s rDNA and rRNA sequences to identify the pesticides, indicate bacterial activity and assess infection risks. These will be combined with biosensor technologies to rapidly monitor the health of the water environment. The applicability will be tested in Nairobi river and Nakivumbu wetland.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Structural and functional studies of enterovirus 2C proteins: promising targets for antiviral therapy.' (EV-2C) targeting Horizon 2020.

assistant: **Abstract**

The enterovirus (EV) genus comprises many important human pathogens including poliovirus, coxsackieviruses, EV-A71, EV-D68 and rhinoviruses. These viruses are responsible for a wide array of diseases ranging from mild to life-threatening, such as neonatal sepsis and paralysis. There are hundreds of enteroviruses, and vaccination to all of these is not a viable option. As such, there is an urgent requirement for effective broad-spectrum antivirals.Enterovirus genomes comprise a positive-sense ssRNA genome which encodes four structural proteins (VP1--4) and seven non-structural proteins (2A--C, 3A--D). The non-structural proteins 2B, 2C and 3A cooperatively hijack host cell proteins and alter host cell membranes and lipid homeostasis to generate membranous replication organelles, which serve as platforms for genome replication and virion morphogenesis.The 2C protein is a particularly attractive target for the development of antivirals due to its high level of sequence conservation. 2C is an AAA+ ATPase with many proposed functions within the virus lifecycle including helicase activity, reorganisation of cellular membranes and encapsidation. Several structurally disparate drugs target 2C on the basis that resistance mutations map to this protein; however, the molecular basis of their effect on 2C is not understood.This project has two main objectives:1. Determine the high-resolution structure of the functional hexameric 2C and inhibitor/ligand complexes by cryo-electron microscopy.2. Use cryo-electron tomography to characterise the interactions 2C makes with viral and host proteins within ex-vivo and in situ replication organelles.Understanding the organisation of 2C within replication organelles will shed new light on its role in the enterovirus life cycle, and the high-r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'See you online? A phenomenological investigation of the limits of empathy in the online sphere' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

According to phenomenologists, empathy is the fundamental way we grasp others as experiencing expressive subjects. It is typically supposed that empathy requires a face-to-face encounter. When we are on Zoom together, instant messaging one another on WhatsApp, looking at Instagram posts or TikTok videos, how do we experience one another? Online do I only have indirect access to others or can I empathetically perceive them? When I wave goodbye to you in person, does my parting see you online make any sense? While there is much debate about whether the internet is good or bad for sociality, such discussions fail to address the question of how we encounter others online in the first place. See you online? A phenomenological investigation of the limits of empathy in the online sphere will provide a phenomenological analysis of the structures of our online social experiences and explore the role empathy plays in online sociality. The investigation is underpinned by a novel methodological approach that integrates insights from the phenomenology of sociality and the philosophy of perception. The project will undertake a platform-sensitive analysis that aims to do justice to the complexity and plurality of our technologically mediated intersubjective encounters and produce: (i) a novel theoretical framework for analysing our online social encounters, (ii) a platform-sensitive taxonomy of online interpersonal experiences, and (iii) an analysis of the limits of the phenomenological concept of empathy by considering its application across various online platforms. To achieve the research objectives, the project is divided into three interrelated strands of inquiry: (i) perceiving the lived body online, (ii) sharing space online, and (iii) taking time online. In the shadow of Covid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project '300mm Silicon Technology for Applications Relying on Light with Photonics Devices' (STARLight) targeting Horizon Europe.

assistant: **Abstract**

STARLight is a major opportunity to establish Europe at the forefront of 300mm Silicon Photonics (SiPho) innovation and thus “Solidify the European photonics ecosystem and accelerate its industrial deployment”.The main STARLight vision is to contribute to European sovereignty relying on the achievement of an efficient and resilient ecosystem and a sustainable society by driving excellence and innovation in the implementation of 300mm silicon photonics manufacturing capacity in Europe (STMicroelectronics, France).The main STARLight goals are:-To offer Europe a realistic solution ensuring its independency on the sourcing of SiPho and other needed optical module compounds (EIC, laser), based on a true European end-to-end value chain, tailored to the global market.-To give Europe the opportunity to move forward with industrial and academic players by joining in the risk-taking necessary for the growth dynamics of SiPho optical modules in Europe, addressing applications such as Data Centers including Hyperscalers, Artificial Intelligence, Telecom, Automotive Lidar, Inter-Satellites communication.-To expand the European photonics technology platform family in terms of accessibility, upscaling and high yield, packaging assembly and providing modelling tools to converge on a mainstream simulation flow.-To be ready for future applications with 200 GBaud (400 Gbps PAM4/lane) by leveraging leading-edge SiPho technology innovations using the integration of heterogeneous non-silicon materials.-To demonstrate the benefit of SiPho optical modules sustainability, providing a better energy-saving, reliability, limited usage of copper and aluminium materials, and reducing the usage of polluting material and water.The STARLight project makes it possible to promote a concept of collaborati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'EUROPEAN PRE-OPERATIONAL IMPLEMENTATION SURVEY ON FURTHER DEVELOPMENT AND EVALUATION OF RDS-TMC (BROADCAST SECTOR)' (EPISODE).

assistant: **Innovation**

EPISODE is to create a database for the broadcasting sector on EU or national projects involving a special non-stop radio traffic message channel (TMC) which will be implemented in several Member States as a new service. Wide availability of such a database is now vital to ensure that TMC can be implemented in an economic way. It is also needed for the complex task of adding TMC material to studio-to-transmitter data channels, to ensure a reliable service without compromising live broadcasting. The project is expected to speed up the introduction of commonly agreed broadcasting systems, and related European standards.The EPISODE project will assess all Research and Implementation projects with any TMC(Traffic Message Channel) components" at the European and National levels and create a single database of activities that affect broadcasters in Europe. This database will be regularly updated during the project timetable and disseminated widely.Whilst previous RTD projects under DRIVE 1 and 2 have developed RDS-TMC (Radio Data System - Traffic Message Channel) components that are nearing readiness for implementation, full specification broadcast systems for the provision of continuous 24hr per day delivery of RDS-TMC have not been assembled before. It is vital to the broadcast community that the EPISODE data base is disseminated to broadcasters, network operators, service providers and equipment suppliers to ensure common approaches and economic solutions.In essence broadcasters will be affected by RDS-TMC in 2 key ways. Firstly new message generation systems, manual or automatic, will create many new sources of travel and traffic information (TTI) which will require editorial management by broadcasters to ensure compatibility on-air between RDS-TMC and the continuing spok
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Combined Positioning-Reflectometry Galileo Code Receiver for Forest Management', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Biomass mapping has gained increased interest for bioenergy, climate research and mitigation activities, such as reducing emissions from deforestation and forest degradation, sustainable management of forests and enhancement of forest carbon stocks (e.g. REDD initiative).However, continuous deforestation activity and forest management requires frequent and accurate monitoring which can be expensive and difficult to attain. In Brazil, optical satellite data is typically used by government but even such does not allow accurate enough mapping due cloud coverage, requiring combination of other sources such as in-situ and air-borne measurements. Furthermore, satellite radar signals can penetrate clouds but still today the spatial resolution is not sufficient.In COREGAL, a low cost unmanned fixed-plane Unmanned Aerial Vehicle (UAV) and service for biomass mapping will allow wide scale mapping in the Brazilian context of forest management. A first of a kind combined Position-Reflectometry Galileo receiver will be developed as main sensor for platform positioning and biomass estimation, the latter using reflected GNSS signals (also called GNSS-R) on tree canopies. High positioning accuracy (centimetre level) is required for surface point reflection determination, which is challenging for remote areas where no GNSS infrastructure is available as in the case of many forests in Brazil. However, Galileo AltBOC E5 signals offer unprecedented pseudorange measurement quality which can be used for novel high accuracy positioning.The UAV will be equipped and tested with a COREGAL receiver and optical cameras for aerial mapping and biomass estimation, enabling wide scale low cost mapping: UAV mapping is at least one order of magnitude lower cost than manned air-borne missions while GNSS-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Barrier breakthrough: Molecular determinants of exodermal divergence for root resilience'.

assistant: **Objectives**

As climate change intensifies, drought has emerged as one of the most severe abiotic stresses, significantly reducing crop yield. Reducing yield loss of crops is crucial by rethinking agriculture to ensure food security. Chickpea (Cicer arietinum), a major legume with high nutritional and several health benefits, is integral to the diets of millions and contributes to sustainable agriculture. However, chickpea faces significant annual yield losses (~50%) due to drought. The root exodermis, a specialized cell layer, plays a crucial role in water retention and protects against pathogens through cell wall barrier deposition. Despite its significance, the mechanisms governing exodermal barrier formation remain poorly understood, due to its absence in the model plant Arabidopsis. Recent findings from the host lab revealed that desi and kabuli chickpea varieties exhibit dynamic inducible and constitutive exodermal barriers differentiation, respectively. My objective is to investigate the underlying mechanism governing these exodermal responses and differentiation. First, I aim to elucidate the gene regulatory networks controlling this exodermal barrier formation through advanced transcriptomic approaches, involving single cell transcriptomic and time-course RNA-seq. These will reveal the developmental and stress-responsive pathways that orchestrate barrier formation. Second, I will test the role of key transcription factors (TFs)/genes through genetic modifications via hairy root transformation, molecular interaction and promoter activity assays. This will provide insights into how these regulators regulate this barrier differentiation, and stress response that impact barrier traits. The novel insights gained from this proposal will not only advance our understanding of cell-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Personalized Nanomedicines for Leukemia Patients' under Horizon 2020.

assistant: **Concept**

Acute myeloid leukemia (AML) remains a devastating disease, while progress in genetic characterization and nanomedical approaches promise a new era of individualized treatments. To prioritize genetic aberrations in AML for therapeutic targeting and to develop a pipeline for personalized nanomedicines I will i) establish a biobank of transplantable primary human AML xenotransplants, ii) fully characterize the genetic landscape of these leukemias, iii) establish the functional hierarchy of driver and passenger mutations in these human leukemia models, iv) develop highly efficient nanoparticle-siRNA formulations that allow in vivo delivery of siRNA to primary AML blasts, and v) design double specific siRNA-based nanomedicines for improved efficacy and tolerability. The expertise of my research team and my institutional settings and collaborations provide a unique platform to achieve these objectives. My access to freshly isolated leukemia blasts allows efficient establishment of a biobank for AML xenotransplant models. In fact, we can serially transplant and expand primary AML cells in immunodeficient mice. The biobank will be an invaluable resource for pharmaceutical product development. I have extensive experience in the genetic characterization and functional evaluation of leukemic cells, which I will apply to the newly generated human AML models. I will use inducible lentiviral approaches to genetically modify human leukemia cells and observe the functional effects in vivo, to identify the relevant targets for leukemogenicity of each primary AML model. Most importantly, I can formulate nanoparticle-siRNA systems that show unprecedented complete uptake into human leukemia cells in vivo and open the door for specific inhibition of any gene. These established tools provid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecule-to-man pain network' (PAIN-Net) targeting Horizon 2020.

assistant: **Abstract**

Neuropathic pain affects 5% of the general population and 40% of patients with neurological diseases, and has a key role in the pathophysiology of cancer pain that affects up to 50% of patients in the early disease stage and 30% of survivors, causing an enormous social burden. Treatments are inadequate with less than 50% of patients achieving 50% of pain relief at best, while up to 30% of cancer pain patients experience insufficient analgesia. Signatures of individual susceptibility to pain and analgesic responsiveness are urgently needed to improve patients’ management. Such advances are expected to originate from integrated clinical, basic science and entrepreneurial research readily translating scientific findings into benefits for patients. To consolidate these aims, a new generation of scientists with wide knowledge in neuropathic pain, focused research skills and experience in the interaction with biotechnology companies is needed. The PAIN-Net programme, based on a highly innovative platform of training-through-research and strongly committed to such objectives, will support such talented and inspired early stage researchers. Their research projects, embedded in an advanced molecule-to-man pain network, will contribute to better understanding individual susceptibility to pain and analgesics responsiveness based on next generation sequencing, whole exome sequencing, epigenetics and pharmacogenomics studies, nociceptor and sodium channel functioning based on biophysics and proteomics studies, targeted analgesics based on high-throughput screening, targeted analgesic delivery based on encapsulated cell bioreactor implants, and to the development and extensive characterisation of the first knock-in mouse models of sodium channel-related neuropathic pain based on the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Research on silent aircraft concepts (ROSAS)'.

assistant: **Innovation**

As a complement to the on-going research and development efforts deployed by the European aeronautical community towards the reduction of civil aircraft noise, efforts which focus on reducing noise emitted at the source by the engine and the airframe like in RAIN and SILENCE(R) programmes, the ROSAS proposal aims at developing the necessary capabilities for the evaluation and selection of innovative silent aircraft concepts, characterized by the shielding of the engine noise sources by the airframe components (wing/fuselage/empennage). ROSAS tackles the main critical issues of alternative installations of advanced turbofan engines through acoustic experimental and theoretical investigations, including a wind tunnel test campaign, and CFD-based aerodynamic work to identify the key phenomena and related risks and achieve an efficient shape design in the power plant area. This will be completed with a multi-disciplinary evaluation of the innovative concepts in order to achieve a fair comparison with the conventional underling engine installation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Protein mediated membrane fusion and DNA transport' in the context of a Sixth Framework call.

assistant: **Objectives**

All living cells are surrounded by a membrane which provides a barrier between the contents of the cell and its environment. Various crucial processes in cells, such as cell/organelle division, or endo-/exo-cytosis, require the fusion of membranes. In e ukaryotes, various proteins have been identified that are involved in different membrane fusion events. In bacteria, membrane fusion occurs during cell division and sporulation. Recently, the first bacterial protein has been identified that is involved i n membrane fusion. This protein, SpolllE, is necessary for the membrane fusion reaction that occurs at a late stage in sporulation in Bacillus subtilis. SpolllE is a member of the SpolllE/FtsK family of proteins which is widely conserved in bacteria. Sp olllE/FtsK are involved in cell division and sporulation, and localise at the leading edge of the invaginating membrane. The proteins consist of an N-terminal region containing four transmembrane regions, a linker region, and a C-terminal domain that me diates energy-dependent DNA transport. During cell division, SpolllE/FtsK are critical for correct chromosome partitioning, whereas in sporulating bacteria, SpolllE transports DNA from the mother-cell into the prespore. This project focuses on the role of the N-terminal membrane segment of SpolllE/FtsK in membrane fusion and DNA transport. The following questions will be addressed: 1) Do the transmembrane regions of SpolllE/FtsK oligomerise to form a DNA pore? 2) Do the transmembrane regions of Spolll E/FtsK mediate membrane fusion? 3) What is the energy requirement of DNA transport across a biological membrane? Full-length SpolllE/FtsK and truncates containing only the transmembrane region will be purified and reconstituted in artificial liposome sys tems. These systems a