RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Childhood health and development - european multicentre study on congenital toxoplasmosis' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Up to 1 in every 1000 children is born with congenital toxoplasmosis but information is lacking on the effect of the disease and prenatal treatment for toxoplasmosis on the child's ability to function and learn. The study involves the assessment, by parent-completed questionnaire, of disability, developmental impairment, behaviour problems and parental anxiety in a cohort of 1278 three year olds born to toxoplasma-infected women. Protocols will be developed for further assessments at age 6 years. Comparisons of infected and uninfected children will allow estimation of the effects of congenital toxoplasmosis and prenatal treatment on adverse developmental outcomes. The findings will have implications for parent counselling, education and psychological needs of infected children, and for screening policies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Easy and rapid generation of light-emitting somatic-transgenic mice to monitor specific disease states and to screen effective drugs' (SOMABIO) under Seventh Framework.

assistant: **Objectives**

For decades, researchers have used small mammals to study the underlying processes of human disease and potential therapies for such ailments. Current strategies for measuring disease progression and/or drug effect usually involve groups of animals being killed at multiple time points for post-mortem tissue analysis. Recently, transgenic strains of mice have been created in which light-emitting luciferase is produced when a disease-specific pathway is switched on or off. High-sensitivity cameras are used to follow the profile of light emission in individual animals during disease induction/treatment, thus avoiding serial culling. However generation of transgenic mice is time-consuming, expensive, and costly in terms of animal usage. A major problem is that every tissue in the mouse may emit light, soorgan-specific effects are difficult to discern. This research programme describes the development of a process of generating light-emitting somatic-transgenic rodents by gene transfer in neonates or in utero. This permits the production of micecontaining bespoke biosensors and avoids the lengthy process of production of germline transgenics. Crucially, specific organs and tissues can be targeted by the appropriate choice of application route and gene transfer vector. This technique is highly adaptable to new developments in biology (for example, new signalling targets, new genetic regulators such as miRNA and improved light-emitting enzymes) and is applicable to any strain of mouse or rat. As proof-of concept several widely-used models of disease will be examined over the duration of this programme of work: i) LPS-induced lung inflammation ii) Bleomycin-induced lung fibrosis iii) LPS-induced liver inflammation iv) Carbon tetrachloride/ethanol-induced liver fibrosis v) colla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Toroidal Propellers for Efficient and Sustainable Aviation', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The TorPropel aims to advance aircraft propulsion technology by developing and upscaling propellers of toroidal geometry, which are distinguished for their thrust efficiency and noise reduction, utilising advanced carbon composites and state-of-the-art robotic manufacturing processes. This technology has the potential to significantly improve the performance of propeller-driven aircraft, a distinct category of aviation platforms ranging from smaller, piston driven or electric aircraft, to vertical take-off and landing aircraft (VTOLs), unmanned aerial vehicles (UAVs) and even aircraft based on novel designs concepts, such as those featuring distributed propulsion systems. TorPropel sees the development of advanced, aerospace-grade carbon composites alongside the implementation of innovative robotic manufacturing solutions to ensure the achievement of critical performance objectives and a lightweight profile, while also prioritising the propellers' recyclability and repairability. Moreover, the project incorporates sophisticated condition monitoring systems directly into the propeller structure, essential for the real-time assessment of propeller structural health, thus ensuring safety, and considerably reducing the time and costs associated with maintenance. Overall, the TorPropel technology is expected to offer significant improvements in propeller performance, durability, weight, sustainability, and recyclability. The proposed technology is thus expected to have a significant contribution to the scientific field of aircraft propulsion technologies, improving upon the operational effectiveness and environmental sustainability of aviation and also by paving the way for a new era of short-distance air travel that is both quieter and environmentally friendly.


**Keywords
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Development of a multifunctional biomaterial patch for buccal delivery of peptide-analogue treatments'.

assistant: **Objectives**

Oral delivery of peptide-analogues (a macromolecule) is one of the great challenges in pharmaceutical research. Thus far, only five peptide-analogues have been converted to oral formulations such as tablets/capsules and all face distinct challenges including low bioavailability, dosage control, patient administration inconvenience and restrictions in use (e.g. undesirable food interactions). The BUCCAL-PEP consortium will join hands to develop a multifunctional biomaterial patch which allows, for the first time, buccal (in the cheek) delivery of peptide-analogue therapies, thereby overcoming these challenges through unique integration of a permeation enhancer (SDC) with biomaterials and a peptide-analogue. The novel formulation enables peptides to diffuse across the mucosal multilayer, thereby effectively achieving their intended pharmacological response. The novel approach will result in an improved quality of patient life and increased treatment compliance. Within this project, the consortium will design, select and manufacture a lead product (with Type 2 Diabetes as showcase indication) that will be validated for performance in in vivo large animal studies. Additionally, a Health Technology Assessment will be performed to support the development an evidence-based value proposition and aid in the development of a commercialisation strategy. The final deliverable of the project is a patch that is pre-clinically validated and ready for clinical trials in the desired showcase indication. Overall, the BUCCAL-PEP project will provide a platform technology for oromucosal delivery of peptide-analogues that will be suitable for a broad range of experimental- and approved peptides-analogues therapies across a multitude of disease indications. BUCCAL-PEP will enable novel pepti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Unveiling interstellar and intergalactic magnetic fields with radio polarimetry and theoretical astrophysics' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

There is a pressing need to chart the origin, evolution, and impact of magnetic fields over the full 13.7 billion year history of the Universe, with implications for particle physics, cosmology, and astrophysics. Key to this endeavour is a detailed physical understanding of how galaxies have become magnetised and what role intergalactic magnetic fields play in shaping the Universe. To make progress, we need to observationally characterize properties such as the strengths and topologies of galactic and intergalactic magnetic fields. I propose a portfolio of ground-breaking research projects that will capitalise on the recently upgraded Jansky VLA radio telescope to provide new observational measurements of interstellar and intergalactic magnetic fields and elucidate their roles in shaping the Universe. A Marie Skłodowska-Curie Actions Research Fellowship will facilitate movement from my current position as an Assistant Scientist at the National Radio Astronomy Observatory in the USA to Newcastle University in the UK. This will enable me to acquire new expertise in theoretical astrophysics with a particular focus on magnetic dynamo mechanisms. This expertise is needed to interpret the observational findings of my research, maximize its impact, and enable me to establish an international leadership position in the study of cosmic magnetism. The move to Newcastle will enable me to develop my capabilities as a professional academic through engagement in student research supervision, classroom teaching, and public communication of science, facilitated by a variety of specialized training programs offered to University staff. Such training and opportunities are not available at my current position within an Observatory. As a result, a Marie Skłodowska-Curie Actions Research Fe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Measurements and modelling of the high-pressure phase equilibria related to the process of depolymerisation and cracking of lignin in near-critical water' (2007-2013).

assistant: **Concept**

Lignin is the second most abundant natural organic polymer on earth, being the first one among those composed of aromatic units. Lignin can be a renewable source of valuable phenolic chemicals, if converted to smaller molecular units, thus representing a potential bio-based alternative to several petrochemical processes. New processes for producing high-purity kraft lignin from wood have recently become commercial and, thus, in the years to come there will be a large amount of this bio-material available for future biorefineries. Among the possible processes for lignin depolymerisation and cracking, the conversion in near-critical or supercritical water is among the most promising. A version of this reactive process is currently under investigation in a laboratory plant at Chalmers University of Technology (Chalmers), but several fundamental aspects of the process are still to be understood. This research proposal aims at integrating the activities currently carried out at Chalmers, focusing on fundamental aspects which are relevant for the process under investigation. More specifically, the proposed project aims at investigating the phase equilibria of the reacting system, composed of lignin and its derivatives, water at near-critical or supercritical conditions, co-solvents, and salts. The phase equilibrium analysis aims at providing information about the number and the nature of the phases constituting the system, depending on the operating parameters (e.g., pressure, temperature, concentration of salts). To reach this goal, the planned activities comprise the realization of a visual apparatus for measuring phase equilibrium at high-pressure and high-temperature, the measurements on samples taken from the reactor currently in use at Chalmers and on representative syn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel Evolutionary Model for the Early stages of Stars with Intelligent Systems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

NEMESIS has the ambition to reshape our understanding on the formation of stars by employing artificial intelligence methods to interpret the largest, panchromatic data collection of young stellar objects. Recent evidence suggests that planets form synchronously rather than sequentially to their host stars, indicating a rapid early evolution of star-planet systems. To ascertain these timescales, it is necessary to first determine the characteristic transitions that describe each phase of star formation. The definition of classes for young stellar objects was made possible more than 30 years ago, due to the first space-based infrared sky surveys.  Whilst successful in determining global properties, current classification is prone to large uncertainties, and therefore, timescales, which are based on population statistics among different classes in a steady-state evolution, remain dubious.   NEMESIS aims to readjust the current classification scheme and its characteristic timescales so that it is concurrent with the most recent observational and theoretical constraints. To meet these goals NEMESIS will compile the largest, panchromatic dataset  comprising of all young stellar objects in nearby star-forming regions, harnessing critical information that resides in data from space missions.  It will reprocess and analyze this unique dataset with supervised and unsupervised machine learning algorithms, deep learning neural networks for object detection, clustering and regression analysis of images in order to advance the analysis and interpretation beyond the current state-of-the-art.  Ultimately, NEMESIS brings big data techniques and hybrid machine learning methods to systematically analyze and interpret large data volumes in order to answer some of the most persisting quest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Tangential Impulse Detonation Engine' under Seventh Framework.

assistant: **Concept**

The proposed project aims at designing, manufacturing and building of a demonstrator for a new engine concept. The new concept replaces the usual turbine of a classical turboengine by a number of Pulse Detonation Combustors (PDC) placed on a disk that rotates under the tangential impulse provided by the exhaust jet of the PDC. The rotating disk is coupled, through a shaft, to the compressor that is placed upstream of the PDC in order to raise its inlet pressure. Two solutions will be considered for the engine propulsion: a propeller, coupled, via a gearbox, to the PDC shaft, or by using the reactive thrust of the PDC exhaust jet, directed at an optimal angle. The PDC inlet with be equipped with aerodynamic valves that control the air entrance into the PDC, thus allowing a significant increase in the detonation frequency, allowing for noise reduction and reduced dimensions. The demonstrator, consisting of a single, fixed, PDC equipped with a fuel injection and ignition system designed for the requirements of the engine concept, will be tested on an experimental facility in order to demonstrate the PDC capability to provide enough power to meet the requirements of the compressor, with sufficient reserve for powering to propel the host aircraft. The project also proposes the design and numerical simulation of the engine compressor, adapted to the requirements of the new engine, most importantly the high vibration load and oscillatory back pressure under which the compressor operates. A last objective of the project is to provide a full definition of the engine constructive solution and a numerical simulation of the flow through the engine that will allow the estimation of the engine performances. The new emerging technology is expected to provide a significant increase in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Regeneration of Cardiac Tissue Assisted by Bioactive Implants' under Seventh Framework.

assistant: **Concept**

Heart failure is the end-stage of many cardiovascular diseases, but the leading cause is the presence of a large scar due acute to myocardial infarction. Current therapeutic treatments under development consist in cellular cardiomyoplasty where myocardial cells or stem cells are implanted alone or encapsulated in natural scaffolds (collagens) and grafted onto infarcted ventricles with the hope that cells will contribute to the generation of new myocardial tissue. This approach seems to have a beneficial effect although it is not completely understood and optimized, yet. Thus, the urgent need of better therapeutic platforms is imminent. In view of this, we created a small interdisciplinary consortium (RECATABI) with experts in areas such as material sciences, tissue engineering, stem cell technologies and clinical cardiovascular research. RECATABI will integrate and synergise their capacities in order to obtain a novel clinical platform to regenerate necrotic ischemic tissues after cardiac infarct with a simple one-time patch technology application.  The consortium will accomplish this by fabricating nanoscale engineered biomaterials and scaffolds that will match the exact biomechanical and biophysical requirements of the implanted tissue. In addition, the construct may induce rapid vascularization to ensure tissue remodelling and regeneration into a newly functional myocardium. The regenerative capacity of the implants loaded with pre-adapted cells (biomechanically and biophysically trained) will be assessed in small (rodents) and large (sheep) animal models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Measuring Quality of Life in the general population and Roma minority in Romania: implications for health policies and economic evaluations'.

assistant: **Objectives**

The importance of health related quality of life (HRQoL) data in research, clinical practice and health policy has significantly increased over the past decade. EQ-5D-5L is one of the most widely used instruments to measure HRQoL worldwide. Nevertheless, the quality of life of the Romanian general population or ethnic minorities has never been assessed before with EQ-5D-5L. Here, I propose to use EQ-5D-5L to provide locally robust HRQoL data for Romania to support reimbursement decisions and public health interventions in wider and vulnerable groups, such as the Roma minority. A representative sample of the Romanian general population and Roma minority will be recruited and face-to-face interviews will be conducted to explore differences in HRQoL according to sociodemographic characteristics, socioeconomic status and ethnicity. Additionally, population norms and social preferences for different health states (tariff) for EQ-5D-5L will be obtained. The successful delivery of this fellowship will be ensured by a fruitful combination of my experience in quality of life and in psychometric properties of questionnaires with the expertise of Newcastle University in health economics and preference elicitation methods. This fellowship will nurture a dual transfer of knowledge between myself and Newcastle University allowing me to gain new skills in preference elicitation methods, economic evaluations and modelling, teaching and project management. Additionally, the 3-month secondment at the EuroQoL foundation will provide me the skills to successfully undertake fieldwork for population-based valuation studies. These combined experiences will enable me to develop an independent career as a researcher that will play a key role in developing health services research and in buildin