RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Towards Very Large Scale Human-Robot Synergy'.

assistant: **Objectives**

Hazardous work environment for humans, growing necessity for an increase in the worldwide agricultural production, and a rapid rise in the public healthcare expenditures due to aging population are among some of the most predominant societal issues where robotics and automation are becoming progressively vital. Distributed multi-robot teams consisting of a large number of robots operating in close cooperation with humans is fundamental for such applications. How to achieve maximum synergy between teams of robots and humans, without jeopardizing human safety and comfort, within the constraints of resources, e.g., computational capacity of the robots, sensor and actuator costs, is still an open question. The focus of this research project is on investigating and developing integrated methods for robot team functionalities with human interaction that are scalable to a very large number of robots, thus enabling their successful real-world deployment.Using state of the art, ecologically valid and immersive virtual environments and virtual reality equipments, the project will study and model human behavior, perception and cognitive responses when they interact and/or cooperate with robots in a large-scale multi-robot scenario. Clear distinction will be made between human users and operators where the former is expected to benefit from directly using a robot that functions as a part of a large robotic team. On the other hand, human operators are those that are in charge of cooperating/controlling a team of robots to accomplish a collaborative task. Eventually, using the human behavior models, cooperative multi-robot functionalities, including localization, mapping and motion planning, will be optimally designed to be extremely scalable within the constraints of ease, safety, e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Pathophysiology of platelet-derived Interleukin 1'.

assistant: **Innovation**

The Interleukin (IL)-1 family of pro-inflammatory cytokines are among the most potent pyrogens, and their excessive production can cause several auto-inflammatory syndromes. Additionally, overabundance of IL-1 cytokines can trigger, or contribute to a range of inflammatory and metabolic disorders. The expression of the key members of the IL-1 family, such as IL-1β and IL-18, is regulated at both the transcriptional and post-transcriptional levels. IL-1β and IL-18, are produced as inactive precursors, which require activation of caspase-1 by the inflammasomes for their maturation and release by from cells, occasionally at the cost of caspase-1 mediated-cell death. We have recently discovered that inflammasomes are released into the extracellular space where they remain active after the demise of activated cells, and that extracellular inflammasomes can amplify inflammation by sustaining extracellular production of IL-1β. However, the sources of extracellular pro-IL-1β are not known. Recent advances in platelet proteomics have revealed that these non-nucleated cells are able to produce their own cytokines, including soluble IL-1β and membrane-bound IL-1α, and are able to significantly magnify IL-1 production by immune cells. As platelets outnumber leukocytes by several folds, they could potentially be the major source of extracellular inflammasomes in the body, or be a major producer of IL-1 precursors that are cleaved by extracellular inflammasomes released from dying immune cells. In this proposal, we will investigate the mechanism(s) by which platelets produce IL-1, and the specific contribution of platelet-derived IL-1 to sterile inflammation, or host resistance to bacterial and viral infection. We believe that a deeper understanding of platelet-IL-1 and their interac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tidal Turbine Power Take-Off Accelerator' (TIPA).

assistant: **Concept**

In this project we will design, build and test an innovative Direct Drive Power Take-Off (PTO) solution for tidal turbines. The consortium’s aim in this project is to reduce the lifetime cost of tidal power by 20%, demonstrated by accelerated life testing of a next-generation tidal turbine power take-off (PTO) solution. Project outputs will be independently verified, and will enable: 1.  Improved performance: 20% Lifetime Cost of Energy improvement over a conventional PTO2.  Improved reliability: extending service intervals from less than 1 year to over 2 years3.  Verified survivability: PTO design lifetime greater than 20 yearsThe results will be disseminated and exploited to maximise the benefit of this project to the ocean energy sector, and to raise investor and market confidence in the emerging tidal energy industry.In order to verify the technology, we will conduct accelerated onshore and in-sea testing of a prototype PTO and achieve third party validation of the design and the test results. In parallel we will develop a commercialisation strategy for selling and licensing the product to tidal energy technology developers, and explore potential uses outside the tidal sector, such as wave power and marine propulsion.The project is led by Nova Innovation, a world-leading tidal energy technology and project developer. Project partners are: SKF, Siemens, The University of Edinburgh, Delft Technical University, Wood Group and the Center for Wind Power Drives RWTH Aachen University.This proposal is being submitted to the call LCE-07-2016-2017: Developing the next generation technologies of renewable electricity and heating/cooling, and is perfectly aligned with the scope of the call: to increase the performance and reliability of ocean energy subsystems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A new Approach to non-parametric Estimation of State-Price Densities with applications to Option Pricing and Assessment of Market Efficiency' (1994-1998).

assistant: **Concept**

Research objectives and contentIn response to the breakdown of the Black-Scholes model, this project attempts to develop a new arbitrage-free method of option pricing based on non-parametric estimation of the state-price density (SPD). This avoids having to directly specify the stochastic process governing the asset-price. The SPD is chosen from an exponential family constructed by minimizing the Kullback-Leibler distance from a prior density subject to a number of moment conditions. This estimate can then be used for pricing various claims, thus offering applications in risk management. Next, the stochastic process implied by the SPD is calculated and a measure of market efficiency is constructed by comparing the processes associated with SPDs at different points in the future.Training content (objective, benefit and expected impact)The DPhil at Oxford is the ideal preparation for an academic career in econometrics. The research itself is supported by advanced level courses conducted by the department in all relevant fields of study, and the University offers courses on specific research skills such as computer programming, as well as more general teaching skills in leading seminars and lecturing. The department has a very active student body that organises a wide range of seminars for graduates to present papers to their colleagues. Moreover, the colleges and department strongly support students in attending national and international conferences.Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Impact of the chromatin environment on the CTG repeat instability involved in myotonic dystrophy type 1' under Seventh Framework.

assistant: **Concept**

Since the identification of unstable trinucleotide repeats (TNRs) as the genetic cause of human neurological diseases, many studies have tried to unravel the mechanisms of repeat expansion. MSH2 and MSH3, DNA mismatch repair proteins, modify expansion in transgenic mice. Circumstantial evidence suggests that cis-elements surrounding the repeats modulate their instability. However, a detailed analysis of the relationship between chromatin environment and trinucleotide repeat instability is lacking. I will address this issue using transgenic mice that show the highest levels of CTG repeat instability observed in mice thus far. These animals carry long human genomic sequences spanning the DM1 locus containing normal or expanded CTG repeats. I will compare the chromatin status around the repeat in different tissues, showing different degrees of instability, throughout development. DM1 transgenic mice lacking MSH2 display predominantly repeat contractions, providing a unique tool to unravel the contraction mechanisms. This will yield important clues towards the development of new therapeutic approaches, possibly by inducing contractions, as the increase in trinucleotide somatic instability with age is thought to contribute to disease progression. The new insights will also be invaluable for halting intergenerational instability, which leads to new and often more severe cases in the next generation. Therefore, the chromatin studies will be extended to Msh2-/- tissues. Double strand breaks (DSBs) may form at CTG repeats and might be repaired via recombination processes, The formation of gamma-H2AX foci, a signature of DSB formation, will be examined at the DM1 locus, to test whether contractions arise as a consequence of DSBs and recombination in Msh2-/- mice. Since the many d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Safeguarding European wild pollinators' (Safeguard) under Horizon 2020.

assistant: **Objectives**

Wild pollinators are a key part of European biodiversity and provide a wide range of benefits to crops, wild plants, and human wellbeing. In Europe and globally, wild pollinators are facing multiple threats, however, the full extent of declines, their complex causes, and the most effective ways to respond to them are not well understood. Safeguard brings together world-leading researchers, NGOs, industry and policy experts to substantially contribute to Europe’s capacity to reverse the losses of wild pollinators. Safeguard will significantly expand current assessments of the status and trends of European wild pollinators including bees, butterflies, flies and other pollinating insects. We will use state-of-the-art models to predict the impacts of pressures on pollinators, paying particular attention to emerging threats, multiple and interacting drivers, long-term and cumulative effects, and multiple spatial scales. Safeguard will establish empirical research for a systematic multi-scale assessment of multiple pressures on pollinators and the context-dependent effectiveness of interventions. Working with our stakeholders, we will provide an improved understanding of the diverse values of European pollinators, and develop and test new approaches using multiple interventions to benefit pollinators, from field to landscape scales across agricultural, natural, and urban systems. We will co-develop with stakeholders an integrated assessment framework and tools that incorporate multiple types of evidence to address pollinator declines and direct mitigation strategies at the local, national, and EU levels. Safeguard will use the significant advance in knowledge to inform national, European, and global policies and decision-making. Finally, Safeguard will increase awareness of w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Accelerating metal-directed assembly, recognition and catalysis with computational methods' (MetAccembly).

assistant: **Concept**

Transition metals (TMs) are found in the core of several phenomena such as catalysis, self-assembly and (bio)molecular recognition and are directly involved in a number of diseases that span from cancer to neurodegenerative disorders. The presence of metal ions or metallocofactors in the active site of enzymes remarkably enhances the diversity of functions displayed by these biomolecules. TMs are also basic elements of approved drugs and MRI contrast agents playing a key role in biomolecular recognition.  Metals in biology are extremely important but are also extremely complex to characterize and its role in processes such as protein assembly and molecular recognition is still poorly understood. These important biological processes take place in a broad range of time scales that span from ultrafast bond vibrations occurring in femtoseconds to slow conformational changes that require milliseconds to even seconds to be completed. The long-term goal of this project is to understand how and where these interactions occur. In the first goal of this proposal, we aim to develop a novel computational method (extended aMD) based on accelerated molecular dynamics that can be used to gain insights into metal-directed assembly, molecular recognition and biocatalysis at a reasonable computational cost. The second research goal of the proposal is to combine state of the art techniques of electronic structure with the new computational method to gain insight into the TMs-driven assembly, biomolecular recognition and catalysis mechanism of amyloid formation, inhibition and catalytic power. Extended aMD will be a versatile method that in principle will be applicable to describe assembly of large biomolecules. Applications in the field of enzyme design and drug discovery are expected in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'James Ussher and the Making of Protestant Knowledge in the Early Modern World' (PROTKNOW).

assistant: **Innovation**

This action will make a ground-breaking contribution to the history of knowledge in early modern Europe. Where previous studies have focused on Protestant scholars as individual actors, this project will use the case of Archbishop James Ussher to show how a leading Protestant ecclesiastical position underwrote and enabled the creation of knowledge. Based at Trinity College Dublin and supervised by Professor Jane Ohlmeyer, the innovative interdisciplinary project will combine the study of Usshers unpublished books and manuscripts with the disciplines of cultural, book, gender, and religious history, art history, the sociology and history of science, and the digital humanities in order to create a novel account of the production of knowledge in early modern Europe. Having reconstructed Usshers intellectual networks, it will then show how these made possible new kinds of advanced scholarship in terms of the study of scripts, how Ussher read and used his collection of printed books and manuscripts in his chronological research, and ascertain the role played by assistants and amanuenses in Usshers working life. In so doing, the action will reveal the importance of confessional networks rather than the pan-confessional Republic of Letters, how far new scholarly methods depended on ecclesiastical preferment and patronage, how the history of reading must use manuscript notebooks in tandem with the evidence of printed books, and how the ascription of published works to individual authors has long obscured the vital roles played by others in their creation. All told, the action will provide a landmark contribution to the making of knowledge in the period between the Renaissance and the Enlightenment and demonstrate the need for a reconceptualisation of intellectual history and th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Lagrangian Modeling of Denitrification and Nitrous Oxide Production in Soils' to be submitted under Horizon 2020.

assistant: **Abstract**

During the fellowship, the experienced researcher Christopher V. Henri and his supervisors Anker Lajer Højberg and Jens Christian Refsgaard of the Geological Survey of Denmark and Greenland (GEUS) will lead an effort improving the prediction of nitrate levels and of the production of nitrous oxide in soils by developing advanced and accurate modeling techniques.   The widespread use of agrochemicals has led to the contamination of many surface and groundwater bodies around the world. Nitrate is a highly problematic contaminant due to its adverse effect on human health and on ecosystems. Understanding the fate of nitrate in the subsurface is, however complex. Indeed, the pollutant undergoes in many cases a sequential biochemically induced degradation, which will reduce levels but also produce nitrous oxide, a potent greenhouse gas.   Today, numerical models are essential in the management of such groundwater contamination. Yet, virtually all available numerical solutions for reactive transport in soils use Eulerian methods that present serious numerical issues, which significantly reduce their applicability.   The proposed project will represent a breakthrough in our representation of reactive transport in unsaturated soils by developing a stable and reliable Lagrangian method able to simulate reactive systems as the Nitrate biodegradation. The method will also allow to identify key processes triggering reactions in soils, which is primordial to improve our management of groundwater contaminations and to better understand the implication that the subsurface production of nitrous oxide can potentially have on climate.   The project will also allow the high-potential applicant to secure a position in Europe and the world-class host institution to maintain excellence throug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ferroelectric REsistors as Emerging Materials for Innovative Neuromorphic Devices', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Neuromorphic computing such as deep-learning algorithms arise as a promising solution to treat the exploding amount of data generated worldwide, but at the cost of expensive time and energy budget on conventional hardware. There is an urgent need for a low-power, compact neuromorphic chip that can support bio-inspired computing: a network of cells collocating storage (non-volatility) and computing (synaptic plasticity).   This work proposes to achieve such cell using a ferroelectric resistor, down-scaled to nanometer thickness to allow direct electron tunneling through the ferroelectric barrier (ferroelectric tunnel junction): the learning functionality (i.e. synaptic plasticity) will be implemented through the control of the distribution of the (non-volatile) ferroelectric domains.  The fellow will bring her expertise in ferroelectric tunnel junctions and will combine it with IBM’s expertise in device and circuits integration and characterization, making use of the state-of-the-art equipment offered by their research center. In order to accelerate the creation of an end-to-end neuromorphic device, she will lead a collaboration with ETH Zurich and will benefit from their expertise in predictive physics-based modeling.  The research project will aim at: (i) the demonstration of a non-volatile and plastic ferroelectric “synapse” made of Hf0.5Zr0.5O2 – a fully CMOS-compatible material, (ii) the development of models of individual cells and of a neural network and (iii) providing design guidelines for neuromorphic hardware based on this technology. The outcome will be to evaluate performances not only of individual synapses but of a neural network as a whole.  Through the Action, the fellow will not only aim at creating a novel technology; but also at leading an interdiscip