RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ACOUSTIC RESONANT FREQUENCY TECHNIQUE IN ON-LINE INTEGRITY TESTING OF STRUCTURES' (ARTIST).

assistant: **Concept**

The acoustic resonant analysis method is an interesting technique for material and structural integrity testing in on-line quality control. At this time only a few applications have been developed for objects with uniform geometry and homogeneous material properties. Often the resonant frequency of a fundamental mode is compared with a certain threshold value and an accept/reject classification is made. No more information is available about the seriousness of the mechanical damage.This project extended the possibilities of the technique towards the classification of objects with more variable shape and material properties. This progress was achieved by the development of new signal algorithms. These algorithms were based on the information extraction of the whole frequency spectrum of the response signal and on the intelligent use of multiple measurements on one object. More detailed information was generated about the type of damage that is observed.The technical feasibility study was performed on two test objects, namely chicken eggs and vitrified clay pipes.- About 5 to 15% of all eggs produced have eggshell defects. These eggs must be sorted out at the moment of grading and packaging. Traditionally this is done by human visual inspection. Higher sorting speeds (>3 eggs per second on each lane of a 12 rows conveyor) require automated detection systems. Currently developed systems are too expensive when applied to low capacity machines (<8000 eggs/hour) and to next generation very high capacity machines (>120 000 eggs/hour). This high cost is mainly due to the high number of measurements per egg (24 hits/egg). The current crack detection rate of about 80-85% must also improve to 90-95%. Based on the new developed technology it proved that two to three measurements pe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Shelterin-chromatin interplay in telomere homeostasis and genome stability' (ShelChromTelo).

assistant: **Innovation**

The linear ends of eukaryotic chromosomes are formed by telomeres, nucleoprotein structures containing double-stranded TTAGGG repeats, ending in a single-stranded DNA 3-overhang. In mammalian cells, the six-subunits Shelterin complex binds telomeres and is critical for telomere homeostasis. Shelterin ensures faithful replication of telomeric DNA, hides linear ends in a looped structure to prevent their recognition as DNA breaks and ensures control over telomere length. Telomeres are packed into nucleosomes, and therefore Shelterin binds in a chromatin context. Interactions between individual Shelterin subunits and nucleosomes have been investigated in vitro, as well as their impact on chromatin organisation. Despite increasing evidence of a Shelterin-chromatin interplay, many questions remain unanswered. The dynamics, affinities and consequences of full Shelterin complex binding to chromatin are unknown. I will employ single-molecule experiments with optical tweezers and bulk assays to monitor the binding of Shelterin on telomeric chromatin and its impact on nucleosomes (and vice versa). The physiological role of this interplay, as well as its regulation, is also largely unknown. I will investigate the impact of an impaired Shelterin-chromatin interaction on telomere and genome stability, as well as its impact on the telomeric proteome and the epigenetic landscape of telomeres. Lastly, I will examine how the Shelterin-chromatin interaction is regulated during the cell cycle. Altogether, this work will provide fundamental new knowledge on Shelterin recruitment and functions at telomeres. Considering that in recent years Shelterin gained interest as an anti-cancer therapeutic target, this basic knowledge has the potential to guide future research aimed at targeting Shelte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Menstrual blood multiomics analysis to better diagnose, understand and treat endometriosis'.

assistant: **Concept**

The MensEndoDiag project aims at finding diagnostic biomarkers and prognostic biomarker candidates, as well as investigating new therapeutic approaches for endometriosis using menstrual fluid, an easily accessible yet overlooked biological fluid.Endometriosis is a common gynecological disorder affecting 6-10% of women of childbearing age. It is associated with pelvic pain and infertility. It leads to a reduced quality of life and is an economic burden. It is defined by the presence of endometrial tissue outside the uterus. Endometriotic lesion form from retrograde menstruation (menstrual fluid reflux through the fallopian tubes) but the precise pathogenesis remains unclear. There are no noninvasive biomarkers currently used in clinical care but they are essential to improve the diagnosis delay, currently estimated at 8 years. There is no specific treatment and pharmacological options are contraceptive. Here, I propose to use menstrual fluid as a relevant biological fluid for endometriosis.In Aim 1, single-cell transcriptomics and soluble protein multiplex assays on 64 menstrual fluid samples will be used to identify candidate diagnostic biomarkers that differentiate endometriosis affected women from healthy controls. Validation of these biomarkers will be carried out in menstrual fluid samples from 250 women. In Aim 2, menstrual fluid derived organoids cultured with or without immune cells will be used to assess endometriosis associated functional changes and to test new immunomodulatory treatments. In Aim 3, longitudinal cohorts will be established to identify prognostic candidate biomarkers for response to surgery and in vitro fertilization.Diagnostic and prognostic biomarkers are essential to assess disease establishment, evolution and to choose the most appropriate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Genetics education: improving non-genetic health professionals' understanding of genetic testing (GENED)' (GENED) targeting Fifth Framework.

assistant: **Abstract**

New genetics information and technologies are expanding rapidly. The rate of increase of trained medical geneticists and counsellors has not kept pace with genetic discoveries and demand for services. As genetic testing moves into mainstream health care tests will be administered by physicians with no training in genetics. There is concern that these physicians cannot interpret genetic tests adequately and may not comply with ethical and clinical guidelines. Using data from 2 successful BIOMED projects, this project will launch a European collaborative education initiative between geneticists, patient support groups and non-genetics health professionals to identify priority needs for education via an extensive survey of non-geneticists. A future RTD project to develop an educational model will be based on these empirical results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel strategies for biomarker discovery and quantification' (BIOMAH) targeting Seventh Framework.

assistant: **Abstract**

Diagnostics impact our lives in many ways, including disease diagnosis, treatment monitoring and long term environmental biomonitoring. The value of biomarker research in the field of diagnostics and predictive medicine has long been acknowledged. There is an increasing realisation that proteins and peptides mediate a rich information stream reporting on the health of an individual and the emergent techniques of proteomics have made possible the identification, characterisation and quantification of vanishingly low quantities of proteins in complex biological fluids. The analysis of the typical protein pattern from a pathological state by proteomics technology offers the opportunity to discover potentially new biomarkers for premature diagnosis and prognosis. Early developments in proteome analysis were based on protein separation through electrophoresis but it was the development of ‘soft’ ionisation modes and extended mass ranges in mass spectrometry which transformed the subject. Although the hold grail of proteomics (the complete characterisation and quantification of every protein in a cell) has not yet been met, the field has experienced some notable successes, and there has been a remarkable expansion of interest in the ten years passed since the term was first coined, (pubmed: 11 references containing the term ‘proteomics’ in 1996, over 12,000 papers in 2006). One of the areas in which proteomics can contribute a lot is that of biomarkers discovery and quantification. In this project we propose the combination of several novel proteomics approaches namely, positional proteomics, protein equalizer technology and absolute multiplexed quantification (QconCAT), to improve the efficiency of protein and peptide based biomarkers for animal disease diagnosis and monitor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Maximizing Synergies for Central European Biotech Research Infrastructures'.

assistant: **Concept**

The main objective of SyBIOsys project is to pull together two research-driven clusters in the field covering the intersection of biotechnology/life science and ICT, more specifically, in the domains of bioinformatics, nanobio, computational biology and biomedicine. The two partner regions – South Moravia (CZ) and Friuli-Venezia-Giulia (IT) - share an interest in this particular research domain and also an interest in developing unique research infrastructures for this domain. While the Italian region has an existing unique research infrastructure in place (AREA Science Park with the Free Electron Laser, a part of ESFRI Road Map), South Moravia is in the process of designing its new research infrastructure and plans to fund it primarily from the EU Structural Funds.  The focus of the project is thus on the valorisation of research infrastructure in these regions and strengthening collaboration with business sector. Emphasis is laid on collaboration, search for complementarities, synergies with activities of the Structural Funds, and on exploiting the experience of other EU regions in respect of opening up research infrastructures to collaboration with business sector. Mentoring will be used as an instrument that will especially contribute to a better design of the newly built infrastructure in South Moravia and, in case of both partner regions, to increase the economic relevance of research infrastructures and their tighter integration with the local economy. Simultaneously, emphasis will be laid on developing partnerships with other regions in the EU with a similar profile and interest with a special emphasis on the Central European region. The project aims, as a part of its activities, to enrol not only stakeholders in the two partner regions, but also to extend the n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'SCIENCE MULTIVERSE - MEET THE HEROES OF THE RESEARCH COSMOS'.

assistant: **Objectives**

What if? Students, teachers, citizens, and science (current and future) enthusiasts will be invited to embark on an exploratory journey of discovery to our cosmos navigating through a multiverse of possibilities and questioning how our world would be without scientific progress. Guided by a group of superheroes (each a fusion of renowned researchers from our common history), participants will be engaged in diverse interactive activities, combining education and entertainment and organised thematically by each universe. This travelling tour around the cosmos will offer them a time visit to outbreaking research achievements and a “what if?” debate. What if multiverses were possible? What if that specific finding did not exist? What would be our life today if at some moment in our history researchers had chosen different careers? Science Multiverse is an immersive STEAM voyage of encounters and celebration that opens research and science to all, showcases researchers’ work and attracts the target audience (and especially those less inclined) to science and research activities. Uncovering daily life heroes, the proposed (pre-event, main event and post-event) edutainment activities will bring participants and researchers closer to each other in settings of science education, communication and experimentation around societal challenge and sustainable development goals. Using various formats, including hands-on stations, talks, workshops, storytelling & plays, and much more, the Night main event will be preceded by several teasers in schools and communities and followed by exploitation actions for sustained use of the educational resources produced (podcasts, stickers’ book with research bios, tutorials for teachers and DIY). Research centres, interface units, collabs, univers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The re-invention of sainfoin: an example of a novel resource for sustainable agriculture' (HEALTHYHAY).

assistant: **Concept**

The proposed RTN adopts a unified approach to a unique sainfoin (Onobrychis viciifolia) collection. It will provide excellent training for young researchers in evaluating traditional resources and developing novel strategies for sustainable agriculture. This is timely because of the pending CAP reforms. The RTN will offer multisectorial and multidisciplinary training at 10 first class research institutions and 3 SMEs in 10 countries. It is based on a structured combination of research and training activities to ensure that the young researchers will achieve optimal development of professional skills for their future careers. The young researchers will greatly benefit from the vast expertise in a wide range of disciplines amongst the partners: agronomy, plant breeding, seed production and marketing, animal nutrition, veterinary science, chemical analysis, biochemistry, genetics and molecular biology. The scientific approach will develop a scientific and technical basis for animal feeding systems based on lower chemical inputs by re-popularising traditional fodder legumes for more efficient, animal- and environment-friendly farming systems. Sainfoin will be a showcase for an excellent fodder legume, which was widely grown in Europe before the use of commercial fertilisers and synthetic drugs. Currently, a considerable amount of research occurs on sainfoin but includes only a few cultivars. This prevents exploitation of its full genetic potential. The unique collection already available within this network and a concerted evaluation will lay the foundation for exploiting the full potential of this traditional forage crop in contemporary cultivation systems. Training will consist of extensive scientific education on a local and network-wide basis and include complementary s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Chrome teflonsurface coating for process rollers' in the context of a Fourth Framework call.

assistant: **Objectives**

A large number of varied industrial production processes currently rely on process rollers coated with Teflon to provide a non-stick corrosion resistant surface. Unfortunately the lifetime of these Teflon coated rollers in the paper, textile, paper and film converting industries is very short (< 1 year). Replacing the Teflon coating requires costly plant down time in addition to the replacement costs of the Teflon. A,s a solution to the above problems the purpose to this project will be the development of a Chrome-Teflon composite surface coating. The composite coating will comprise a chromium structure filled with Teflon cured at high temperatures to give permanent bonding. The coating will comprise the wear resistant properties of Chromium with the non-stick properties of Teflon. This will extend the lifetime of the coating by at least 10 times that of existing Teflon coatings. In summary the coating will exhibit the following properties which represent the project research goals: * A non-stick surface equivalent to normal Teflon coatings * A anti corrosion surface equivalent to normal Teflon coatings * A higher wear resistant surface able to withstand a doctoring action for longer periods * A temperature resistant surface equivalent to normal Teflon coatings * A lifetime of between 5-10 years (as opposed to existing Teflon coatings which have a 1 year lifetime) These goals will be verified through the production of a viable coating composite for demonstration in the paper, textile, paper and film converting industries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Evolving governance structure of the firm in a knowledge-based economy' (E-GOST) targeting Fifth Framework.

assistant: **Abstract**

This proposal consists in organizing a series of three worships on the evolving governance structure of the firm in a knowledge based economy with the aim to create synergies between various approaches of the problem and to play an active role in the construction of a common body of knowledge to be shared by a larger community. The ambition is not only to re-consider the theory of the firm but also to explore the empirical dimensions and to expose the theories to facts and rice-versa. As a result it is expected to come up with various publications which could be condensed into some kind of reader to be used in various institutions for teaching post-graduate and doctoral students. Furthermore it should increase the understanding by policy makers and firms of the necessity to align public incentives with private ones in terms of knowledge creation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High Resolution In-Situ Holographic Recording and Analysis of Marine Organisms and Particles' in the context of a Fourth Framework call.

assistant: **Objectives**

Our objective is to develop a prototype, underwater holographic camera for recording high-resolution, 3-d images of marine plankton and seston within the upper water column. The holo-camera" will be controlled and deployed from a ship or fixed buoy. A dedicated, hologram replay facility containing automated image analysis and data extraction will allow species identification and measurement of local concentration of a variety of organisms and particles. We will demonstrate and evaluate the system in a series of sea trials. The overriding benefit of holographic imaging is that it allows nonintrusive, in-situ, recording of living organisms and inanimate particles in their natural environment. Novel aspects include our use of pulsed lasers to record large sample volumes (about 100 l) and incorporation of both in-line and off-axis holography depending on the specific requirements of the user. Although recording takes place in water, image replay (a projected real-image) is carried out in air, in a customised laboratory replay and data aquisition facility. Image processing of holographic real-images has hitherto received little attention and represents another unique and novel contribution by the project team. This multidisciplinary and multinational project, covers marine science, laser technology, holography, image processing and offshore technology. The proposal describes how the individual components are developed and integrated into the final system before deployment in sea trials. It is important that all partners work towards the same common aims, and that each is informed of the progress of others. To this end, the project proposal contains not only a detailed work-plan, a description of methodology and projected time-scales, but a simple and effective management and