RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dissecting Cross-Regulatory Interplays in Tumor-Associated Macrophages' (X-TAM).

assistant: **Concept**

Macrophages are specialized innate immune cells with central roles in homeostasis and disease. Uponexposure to micro-environmental stimuli, these cells can adopt a variety of phenotypes ranging from immunestimulation and cytotoxicity to immune suppression and tissue repair. Dynamic transitions between thesefunctional properties in response to tumor signals is thought to underlie the generally pathogenic role ofmacrophages in cancer. At the same time, macrophage plasticity could be exploited to therapeuticallyreprogram the phenotype of these cells by pharmacological, cell and gene therapy approaches.Current models of macrophage activation are based on in-depth analyses of the effect of individual stimuli,such as pro- or anti-inflammatory cytokines, on the biochemical, cell biological, epigenetic, transcriptionaland post-transcriptional landscape of macrophages. However, these studies do not take into consideration theinterplay that these stimuli may have when present at the same time.This project aims to elucidate how macrophages integrate incoherent environmental stimuli at the genomiclevel, and translate them into context-specific gene expression programs. Because concomitant activation ofantagonistic pro-inflammatory and anti-inflammatory pathways is almost invariably observed in cancer, wepropose that these interplays are critical determinants of the biology of tumor-associated macrophages.Our approach integrates cutting-edge genomics and computational modelling with in vitro functionalscreenings and in vivo manipulation of macrophages, building on uniquely available gene therapy platforms.Successful completion of this project will generate widely exportable paradigms of gene regulation in theimmune system, and deliver innovative cell and gene therapy strategies to m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Ultimate modelling of Radio foregrounds: a key ingredient for cosmology'.

assistant: **Objectives**

Understanding the Physics of Inflation is one of the key questions in present-day fundamental cosmology.  For this purpose, the study of the polarization of the Cosmic Microwave Background (CMB) anisotropies provide a unique probe to the early Universe. However, it is well-known that foreground signals, and in particular emission from our Galaxy, will be the major limiting factor of the possible constraints on the existence of B-modes.This proposal will make use of ESA’s PLANCK satellite mission (30-857 GHz), in combination with the ground-based observations provided by the QUIJOTE experiment (10-20 GHz) and other ancillary radio maps, to address the still open problem of  the detailed physical modelling of the radio foregrounds in polarization. This project will provide: a) state-of-the-art legacy maps of the synchrotron and  the anomalous microwave emission (AME) in the Northern sky; b) a detailed characterization of the synchrotron spectral index, and the implications for cosmic-rays electron physics; c) a model of the large-scale properties of the Galactic magnetic field; d) a detailed characterization of the AME, including its contribution in polarization; and e) the best complete and statistically significant multi-frequency catalogue (from 10 to 217 GHz) of radio sources in both temperature and polarization.  The combination of PLANCK and QUIJOTE will provide reference data products which will be an asset  for other sub-orbital experiments, as well as in the preparation of future space missions. Finally, we will also provide specific software tools for a more efficient exploitation of our data products, with functionalities far beyond of the existing ones. These tools will not only allow an advanced visualization, but also they will allow the possibility of carry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Global Process To Improve Cynara cardunculus Exploitation for Energy Applications.' (BIOCARD) targeting Sixth Framework.

assistant: **Abstract**

The proposal aims at demonstrating technical and economical feasibility of a global process for cardoon (Cynara cardunculus L.) exploitation for energy applications. This energy crop is appropriated for Mediterranean Area, where high problems about water i nsufficient exist. A combined process to produce a low-cost liquid biofuel from seeds and energy from lignocellulosic biomass is proposed. Different technologies for biomass energy conversion will be researched and compared. Additionally to increase compet itiveness and breaking the cost barriers, new heterogeneous catalysis for liquid biofuel production will be tested.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Targeting kidney fibrosis by a novel myofibroblast specific small molecule inhibitor' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Chronic kidney disease (CKD) is a progressive disease that is prevalent in 10% of the developed world and develops as a result of diabetes mellitus, hypertension, glomerulonephritis or acute kidney injury. Over time, CKD can progress to end-stage renal disease (ESRD); a condition that can only be treated through hemodialysis or kidney transplantation, posing a severe medical, societal and economic challenge. Fibrosis is recognized as a key pathological mechanism in CKD, responsible for slowly destroying the tissue architecture of the kidney. Current therapies for CKD alleviate symptoms of the disease by controlling hypertension and hyperglycemia, but, while fibrosis is as a promising therapeutic target, no antifibrotic therapy for the kidney have reached the clinic. Hence, there is an urgent need for disease-modifying and curative treatments that can halt fibrosis.  In FibroTarg we will assess the technical and commercial feasibility of Fibrolisine, a first-of-its-kind anti-fibrotic drug candidate, for the treatment of CKD. Our preliminary data has confirmed a unique expression profile of our therapeutic target and reduced fibrosis onset in in vivo knockout models without side-effects after kidney injury.  Hence, Fibrolisine is expected to target the process of fibrogenesis and halt the progression to ESRD in early-stage CKD patients. Through the activities in FibroTarg project, we aim to demonstrate the antifibrotic potential of Fibrolisine in advanced human kidney fibrosis organoid models and in vivo models of kidney injury. Concurrently, we will investigate the commercial potential of Fibrolisine by analyzing the commercial landscape and develop an initial commercialization strategy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Computational Geometry for efficient Motion Design by implementation through mechanisms' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The research of the project proposed focuses on Mechanism Design in its interdependence to Motion Design with regard to spatial motion problems occurring in Solid Mechanics. That is, the design of motions interpolating a sequence of positions of a spatial system will be combined with the design of suitable mechanisms which can guide these positions.In engineering practice, one has to decide whether a mechanism or manipulator should be used to guide a required motion weighing up the technical and economic reasons.Currently, spatial motion problems are often solved by manipulators which beside high purchase costs raise problems relating their control, required space etc. Their flexibility is not essential for many applications. Therefore, solutions of spatial motion problems using mechanisms seem often rather reasonable in the context of economic expediency.From a kinematic point of view, one has to assign the determination of a suitable interpolating motion to the determination of a mechanism whose end-effector is capable of attaining these positions. This research will be done using geometric approaches coming from Computer Aided Geometric Design, Algebraic Geometry, Computational Line Geometry, Kinematics et al. The geometric idea behind it is to connect the modeling of motions either mathematically defined or implemented by mechanisms with well-known design of curves and surfaces.Concerning the career development, the main aim of the project proposed is to widen the scientific profile of the applicant in order to achieve an independent research career. One main objective is to establish an independent research group in this field. In order to achieve this goal, the project partly aims at the advancement of collaborations in this up-and-coming research field, in the fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developing and implementation of a new generation of nanosafety assessment tools' (NANOGENTOOLS) targeting Horizon 2020.

assistant: **Abstract**

NanoMaterials safety is of great societal concern and raises many questions for the general public, governments, industry, scientists and regulators. Identifying and controlling the hazards associated with NMs is required to ensure the safety in parallel to exploiting the technological benefits.NANOGENTOOLS answers this challenge by creating a collaborative excellence-based knowledge exchange network that will: i) push forward knowledge via method development and pre-validation, ii) train scientists in new methodologies to assess long term nanosafety, and iii) support their inclusion in standardization and EU regulations.NANOGENTOOLS combines toxicogenomics, proteomics, biophysics, molecular modeling, chemistry, bio/chemoinformatics to develop fast in vitro high throughput (HTS) assays, with molecular based computational models for nanotoxicity. Its objectives are to:· Provide solutions for faster, more reliable assessment of NM toxicity and propose HTS and omics tools for predicting toxicological properties of NMs.· Develop new bioinformatics methodologies for analyzing -omics data and create an open database in collaboration with the EU Nanosafety Cluster.· Conduct research and training on biophysical techniques and mathematical models for accurate and fast nanotoxicity prediction.· Build/improve the safe by design concept, demonstrated using carbon-NMs and nanosensors.·  Place our new knowledge in the context of regulations and EU roadmaps.NANOGENTOOLS brings together cutting edge research, innovative knowledge-transfer and co-development, and cross-sectoral and cross-disciplinary secondments linking EU academic institutes/networks with industry and policy makers across 8 countries. Expected impacts include pre-validated tools for efficient cost-effective nanosafety
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Synaptic signatures: Understanding thalamocortical circuit specification and disease vulnerability' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Sensory processing is frequently altered in disorders like autism, schizophrenia and bipolar disorder. Neuronal circuits from the thalamus to the primary somatosensory cortex (S1) play a critical role in sensory processing. Dysconnectivity of such circuits is implicated in disorders associated with sensory processing impairments. The posteromedial thalamic nucleus (POm) connects to intratelencephalic (IT) layer 5 (L5) pyramidal neurons (PNs) of S1, regulating somatosensory processing. The mechanisms regulating connectivity and function of the POm>IT L5 PN circuit remain unknown. Cell surface proteins (CSPs) drive circuit formation and specification. I hypothesize that a unique combination of CSPs orchestrate the structural and functional connectivity of this circuit, and can explain vulnerability to certain disorders. To understand the molecular mechanisms involved in POm>IT L5 PN connectivity in mice, I will first isolate POm>IT L5 PN synapses and characterize their molecular signature with mass spectrometry. Next, I will use these data and information from public databases on the genetics of neurodevelopmental disorders, to select 5 postsynaptic CSPs to further study. Using genome engineering, I will next knock-out the selected CSPs, one at a time, and analyze the impact on the structure and function of the circuit. Last, to deepen our mechanistic understanding of these proteins and gain insight to the downstream pathways, I will map changes in the molecular composition of these synapses. This project will allow us to study for the first time the molecular correlates of the functional specificity of this circuit and provide insight in the pathomechanisms of associated disorders. The experience of the de Wit lab in studying mechanisms of synapse function, the cutting-e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Key Aerodynamic Technologies to meet the Vision 2020 Challenges' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

KATnet II is a co-ordinating action on Key Aerodynamic Technologies supporting the ACARE Vision 2020, and in particular it's Strategic Research Agenda. KATnet II's objective is to identify and assess those aerodynamic technologies that are needed to reach the Vision 2020 goals, and to be the European focus for these technologies. The results of this work will be reported in a strategy paper, which will be delivered to ACARE and other influential organisations in the field. KATnet II is proposed as the successor of the highly successful FP5 KATnet Thematic Network (2002 to 2005). The major objective of both projects is to maximise the industrial return of European R&TD investment. KATnet II addresses the relevant Technology Areas: Aircraft Configuration, Drag Reduction and Separation Control Technologies including the eight ongoing EU funded aeronautical projects/platforms AWIATOR, EUROLIFT II, FLIRET, HISAC, NACRE, REMFI, SUPERTRAC and TELFONA. Other relevant non-EU activities addressed by KATnet II are AIRnet, GARTEUR, ERCOFTAC and corresponding national programmes. Networking activities provided by KATnet II are:* R&T Strategy Development & Exploitation (WP1)* Multidisciplinary Technology Assessment (WP2)* Dissemination of KATnet II Information (WP3)* KATnet II Communication Platforms (WP4). The expected main achievements include:* Identification of relevant technologies, investigation of their maturity and development of strategies for their implementation into future aircraft * Multidisciplinary assessment of candidate technologies for a virtual aircraft configuration as defined in KATnet* Dissemination of KATnet II information via the KATnet II homepage and newsletters; intensified contact and involvement with the academic community by organising seminars, workshop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Modelling agroecosystems under global environmental change' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

New formulations of environmentally friendly lubricants, EALs, based on sunflower and synthetic ester oils. New compositions and structures of low friction coatings, LFCs. Experimental tribological results from LFC/LFC and LFC/EAL tests. The gained knowledge is used in optimising LFC/EAL tribosystems and finally to facilitate the application/validation of these tribosystems in grinding machines and hydraulic components.This project, Modelling Agroecosystems under Global Environmental Change (MAGEC), will provide modules of soil / plant interactions in agroecosystems to contribute to patch (<0.lkm) and regional scale (10-100km) modelling frameworks already under development within the EU-TERI programme. MAGEC will contribute to area 1.2 of the Environment and Climate programme. Specifically, it addresses Section 1.2.2 on Biospheric Processes, and is intended to be implemented through the EU-TERI initiative. MAGEC addresses issues of climate and land-use change in agroecosystems and contributes to existing EU-TERI-funded programmes; in particular it complements ETEMA by providing descriptions of agroecosystems. The link with ETEMA is strong: PIK, who are leading partners in ETEMA are also partners in MAGEC and through this contact the complementary approaches between the two projects can be harmonised from the start of MAGEC. The added value of such an initiative is clear. Agroecosystems cover over half of the land area of the EU and the greatest potential changes in land-use are likely to occur on this land yet they are not currently represented under the EU-TERI programme. Agroecosystems are an essential component of any patch and regional scale modelling framework. The objectives of MAGEC are : a) to evaluate to process descriptions used by leading agroecosystem soil a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Cavity-enhanced efficient optical quantum memory for multiplexed entanglement distribution'.

assistant: **Concept**

Recent breakthroughs in quantum technologies combining academic and R&D efforts have ushered quantum networks into a new era, where quantum information can be stored, processed, and transferred. A key challenge in this new era is enhancing the capabilities of individual nodes to realize a quantum repeater that will extend quantum links to reach continental distances. Quantum memories are one of the building blocks for synchronizing temporal events in a quantum repeater, allowing entanglement distribution beyond the physical limitations of fiber loss. In this context, our proposed research seeks to push the boundaries of quantum communication by developing a cutting-edge quantum memory designed for high-rate, long-distance entanglement distribution. The project focuses on the development of an efficient, multiplexed, cavity-enhanced quantum memory using a praseodymium (Pr3+)-doped yttrium orthosilicate (YSO) crystal, known for its long coherence times and multiplexing capabilities. The first objective is to demonstrate a cavity-enhanced on-demand quantum memory for single photons, using the spin-wave atomic frequency comb protocol. The challenge is to mitigate optical loss and noise to enable single-photon storage with a high signal-to-noise ratio. The second objective aims at implementing a novel spatial multiplexing scheme that leverages non-trivial collective spin excitations in the cavity memory. This will be combined with temporal and frequency multiplexing to enhance the memory's capacity to store multiple degrees of freedom. The ultimate goal is to distribute light-matter entanglement using cavity-enhanced multimode quantum memory over a 50 km deployed optical fiber in a metropolitan area. Our approach seeks to achieve higher efficiency and increased rates, which