RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Neural regulation of immunity', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Survival of living organisms depends on their capacity to develop defence mechanisms against environmental challenges that cause tissue damage and infections. These protective functions involve the nervous system and the immune system, two systems traditionally considered as independent. However anatomical and cellular bases for bidirectional interactions between them have been established and a new paradigm on a regulatory role of the nervous system on immune functions is emerging. Pain is one of the major signs of inflammation. Upon acute injury, inflammation or infections noxious signals are perceived by nociceptors present in tissues, such as the skin. These sensory neurons convey the damaging information to the brain and release a number of mediators locally that could modulate immunity. The goal of this project is to decipher the functional role of sensory neurons and pain sensitivity on immune responses. We will tackle this highly challenging question by studying the immune responses to vaccination in genetic mouse models in which skin innervation by nociceptors is deficient. Our preliminary results are very promising as we already demonstrated that deficits in sensory skin innervation affect both the innate and adaptive immune responses to intradermal vaccine. We will further study the cellular and molecular mechanisms involved in this local and systemic modulation of the immune response by the nervous system. As a complementary approach, we will address the role of an exacerbated pain response on immunity through the selective stimulation of nociceptive neurons in wild type animals.This interdisciplinary study is designed to provide new insights into how the nervous system instructs the immune system. Results from NEURIMMUNE are expected to open new avenues of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Pluripotent stem cell resources for mesodermal medicine' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Harnessing the capacity of pluripotent stem cells (PSCs) to produce functional cell types with precision and at scale will enable new treatment modalities for degenerative diseases. A major target for such therapies is mesodermal tissue, muscle, bone and cartilage. The goal of PluriMes is to create a bioengineering platform for directing PSCs into specific classes of mesodermal/mesenchymal progenitor. The project pulls together stem cell experts, genetic engineers, developmental biologists, cell therapy pioneers, bioengineers and specialist SMEs in a cross-disciplinary collaborative effort. Close-working between partners will be maximised through specialist workshops, laboratory exchange schemes, regular workpackage meetings, and joint Deliverables. The concept underlying PluriMes is that refined control of early fate decisions to produce correctly specified progenitors will be obtained through confronting developmental principles with engineering logic. We aim to define ground states and resolve issues of hierarchy, heterogeneity and stability in order to provide standardised PSC and mesodermal progenitor cell populations. A toolbox of fluorescent reporters will be developed for live cell tracking. Cutting edge bioengineering approaches will be implemented for dynamic topological administration of morphogens, matrices, small molecule modulators and siRNAs in 2D and 3D contexts. Through SME involvement, culture systems will be optimised for specification and subsequent stable expansion of mesodermal progenitors. The capacity of PSC-derived mesodermal cells for maturation into skeletal muscle, bone and cartilage will be tested in vitro and in vivo using lineage reporters. Potency will then be evaluated in pre-clinical disease models. Scale up protocols will be implemente
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Simulation of metal Solidification in Additive Manufacturing processes' under Horizon 2020.

assistant: **Concept**

The project is aimed to the enhancement of numerical simulation tools for the Additive Manufacturing process, focusing on analysis of temperature evolution and solidification behaviour of material during the Metal Deposition process.A novel approach to the thermal FEM simulation of Metal Deposition processes is proposed, with the implementation of an innovative solidification model in COMET (a Finite Element (FE)-based framework for the solution of engineering problems). The proposed  solidification model directly describes the evolution of solid fraction in function of time and depend from some empirical parameter. Examples of simplified AM processes will be studied in order to calibrate the model and evaluate advantages in terms of CPU costs and accuracy. Dedicated semi-empirical models for evaluation of local microstructures in function of temperature history of metal during the AM process will be also developed, implemented and experimentally calibrated. Mechanical properties will be evaluated by means of direct empirical correlation with local microstructures.  Finally, real cases of complete AM processes will be studied in order to validate the overall AM simulation tool.  The final objective is to develop an innovative, useful and quick simulation tool for the optimization of the AM process.End users such as software houses and mechanical industries are strongly interested the enhancing of simulation accuracy and CPU time. The impact of process optimization in terms of time, cost and product quality leads to clear benefits not only for end-users but also for society in general.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Inaugural Euroconference: Eastern Mediterranean Region of the International Biometric Society.' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Biostatistics is a vital part of the science of medicine and biology and lies at the heart of the design, analysis and interpretation of research studies in those fields. Its application to the conduct of clinical trials of new therapies is recognized as paramount by drug regulating agencies in Europe and America. Its central role in the establishment of generic and environmental causes of disease (epidemiology) is recognized by public health experts around the world. The International Biometric Society (IBS) is the primary international organization for biostatistics. The Society divides itself into geographical Regions. Until now there has been no Region of the Society in the Eastern Mediterranean, and no mechanism for biostatisticians in this region to meet together. This conference will be the inaugural meeting the new Eastern Mediterranean Region of the IBS. The conference will bring together internationally recognized biostatisticians from Europe and America to meet and discuss currently important topics in biostatistics with biostatisticians in the Eastern Mediterranean area.The conference will emphasize building contacts between the participants for future collaboration and training, both within the Eastern Mediterranean and outside. The conference will address several themes that are both important and the subject of current research. These will include: within the topic of clinical trials, the design and analysis of bioequivalence studies, methods of interim analysis, multiple endpoints, and survival analysis; and within the topic of epidemiology, longitudinal analysis, multiple endpoints, and model selection. The role of statistics in drug regulation will be emphasized.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00143-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Post-transcriptional Regulation of Germinal Center B Cell Responses in Immunity and Disease' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Antibodies secreted by B cells of the adaptive immune system establish an essential barrier against bacteria and viruses and their presence is the hallmark of protective vaccinations. B cells are licensed for their tasks during germinal center (GC) reactions and differentiation into antibody-secreting plasma cells. Unfortunately, B cell-derived autoantibodies and proinflammatory cytokines can cause or contribute to autoimmune diseases.While major transcription factor networks regulating protective (or pathogenic) GCB cell responses have been identified and characterized, little is known about the post-transcriptional regulation by RNA-binding proteins (RBP), whose number rivals that of transcription factors.We postulate that RBPs exercise critical post-transcriptional control over germinal center B (GCB) and plasmacytic cell physiology and we aim to identify and molecularly characterize these regulatory mechanisms.To this end, we will complement sophisticated genetic mouse models with novel cell culture systems. We will monitor RBP activity with fluorescent sensors and use proteomics to reveal RBPs regulating the protein abundance of critical mediators of GCB and plasmacytic cell fates. In addition, we will conduct genetic screens to uncover relevant functions of a short list of 40 RBPs, whose protein expression we found to differ significantly between GCB and mantle zone B cells. Ultimately, we will use cellular immunology and RNA biochemistry to elucidate how these RBPs exert their post-transcriptional control. Through the integrated power of our multi-disciplinary approach we will thus pinpoint and investigate the functions of key RBPs regulating the biology of GCB and plasmacytic cells. GCB-PRID promises to uncover profoundly new insights into post-transcriptional r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Low cost low energy technology to desalinate water into potable water' (DESOL).

assistant: **Innovation**

In South of EU tourism is a main business on which up to 90% of employment depends on. Tourism requires ca. 300 Litres/pers./day of drinking water. The areas where most of the hotel resorts and secondary facilities are located scare on potable water. The available source of water is sea and groundwater which has to be desalinated too. Hotels and restaurants are mainly local SME business. Due to the high demand of potable water there is a threat to this increasing industry. SoA technology to desalinate water is Reverse Osmosis, which is expensive in invest and operation and due to the high electrical energy consumption not environmental friendly. The proposing SMEs have come together to develop DeSol as innovative, environmental friendly and efficient process that desalinates water using thermal energy at a low level which will be provided by solar collectors. The low temperature level of evaporation could be achieved through processing at vacuum pressure. Vacuum is generated through the water column in the effluent formed by the gravity of the condensed water. DeSol will be a highly competitive product with significant technological features: Evaporation at temperature of 60deg.C in a vacuum atmosphere generated by the gravity of effluent water column; Raw water charged by a maintenance free pump combining a piston pump with a directly coupled Stirling motor; Modular design for flexible adaptation to low or high capacities required by customers; Control and adjustment by hydro-thermo-mechanical systems to achieve energy efficiency of up to 92%. The system will be cost-efficient, save investment and energy, easy to be operated and designed for low maintenance efforts at a long life time. Innovation barriers have to be overcome to realise the self-adjusting the water colu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Demonstrating and promoting the take-up of new ways of FLEXIBLE WORKING among outlying regions and SMEs.' (FLEXWORK).

assistant: **Concept**

To facilitate the practical take-up of new ways of flexible working using technologies from within and outside IST, in outlying or technologically disadvantaged regions with special emphasis on SME's. To demonstrate to SME's in these regions how Service Deployment Templates (detailed guidelines and procedures) can enable them to make use of existing technologies and new technologies. To encourage synergy between IST technologies and organisations using the European Regional Development Fund and European Social Fund, by working with EURADA (European association of regional development agencies), ADAPT (European employment network) and Telework organisations.The project will develop Service Deployment Templates, using SME's in developing regions in Ireland, Portugal and Eastern Europe as usage case studies. It will channel and demonstrate these Service Deployment Templates and the underlying flexible working technology directly to the users by participating in their own conferences, workshops, publications and websites. It will support all levels of flexible working technology, from application software (e.g for collaborative working and virtual meetings) to the underlying communications infrastructure, with emphasis on the use of open standards.The project will raise the awareness among regional development agencies involved in the use of the Regional Development Fund, of new communications infrastructure technologies in which they could invest.It will feed requirements, issues and comments back to the IST projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Deciphering the Effect of Vegetation and Erosion on basalt and carbonate weathering by Novel Denudation Rate Approaches' (DEVENDRA) under Horizon Europe.

assistant: **Objectives**

The chemical weathering of rocks on the Earth’s surface draws down atmospheric CO2, balancing emissions from volcanoes and maintaining habitable temperatures. Basalt and carbonate rocks are particularly crucial in this balance, because they are efficiently weathered: as estimated from studies of the dissolved elements in rivers, basalt accounts for 20-35% of modern global silicate weathering and CO2 consumption flux, despite only covering 5% of Earth’s surface. To formulate sensitivities and feedbacks between weathering of these rocks and climate, we need an accurate description of the exact processes that drive the conversion of rock to soil by weathering. Besides water flow, erosion rate and vegetation are thought to exercise significant control. Currently, however, we lack the tools needed to decipher these controls, because the preferred approach used to quantify erosion and weathering rates – cosmogenic nuclides, produced in situ in quartz – does not work in basalt and carbonate lithologies.  The aim of DEVENDRA, dedicated to the pioneer of cosmogenic nuclide geochemistry Devendra Lal (1920 – 2012), is to eliminate this blind spot using a novel method never applied to basalt and carbonate lithologies: the ratio of cosmogenic beryllium-10 rained out from the atmosphere to stable beryllium-9 released by weathering. DEVENDRA will develop this system as a novel erosion and weathering rate meter for these rocks, and will use this new method to calibrate – using globally-distributed soil profiles and catchments of differing climate and erosion rate – the laws that govern weathering and CO2 drawdown in these rocks. The outcomes from DEVENDRA will refine the global weathering models that are used to understand Earth’s carbon cycle on geological time scales, to predict the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Novel Personalized Cellular Therapy Approach for Immune Diseases'.

assistant: **Objectives**

This project will commercialise TLA Gut - the novel medical device for the treatment of Inflammatory Bowel Disease (IBD). IBD belongs to the group of Immune Mediated Inflammatory Diseases (IMIDs) caused and maintained by an exaggerated inflammatory response triggered by an imbalance of the immune system. Research at Karolinska Institutet in Sweden has shown that IMIDs are caused by increase in specific inflammatory cells, which migrate to the site of inflammation by chemotaxis and induce disease-causing inflammation through release of cytokines in tissues. TLA Gut is a globally unique technology, and the first medical device with a proven clinical efficacy in removing those disease-causing cells from the blood of the patient through therapeutic leukapheresis. Today, the development and commercialisation of new therapies for IBD is in great demand among clinicians and their patients as current treatments offer an overall long-term remission rate of only 50-60% and carry the risk of life-threatening side effects. There exists a strong business opportunity for a therapy that would create a new and personalized way to treat IBD. TLA Gut is positioned to satiate this demand. To date, TLA Gut in vivo proof of concept has been established in a Phase I/II clinical trial on IBD patients in Stockholm. In the project, the Phase III study will be performed together with regulatory development work required to get market access upon completion of the project. IBD poses a significant socio-economic burden internationally. In Europe, a direct healthcare cost of IBD is estimated to € 4.6–5.6 billion per year. Once introduced in the clinical praxis across the EU, TLA Gut will be a safe and cost-efficient treatment option for IBD patients. The overall business strategy of TLA is aligned
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Critical phenomena in random matrix theory and integrable systems' (CRAMIS), addressing dissemination and exploitation.

assistant: **Impact**

The main goal of the project is to create a research group on critical phenomena in random matrix theory and integrable systems at the Université Catholique de Louvain, where the PI was recently appointed.Random matrix ensembles, integrable partial differential equations and Toeplitz determinants will be the main research topics in the project. Those three models show intimate connections and they all share certain properties that are, to a large extent, universal. In the recent past it has been showed that Painlevé equations play an important and universal role in the description of critical behaviour in each of these areas. In random matrix theory, they describe the local correlations between eigenvalues in appropriate double scaling limits; for integrable partial differential equations such as the Korteweg-de Vries equation and the nonlinear Schrödinger equation, they arise near points of gradient catastrophe in the small dispersion limit; for Toeplitz determinants they describe phase transitions for underlying models in statistical physics.The aim of the project is to study new types of critical behaviour and to obtain a better understanding of the remarkable similarities between random matrices on one hand and integrable partial differential equations on the other hand. The focus will be on asymptotic questions, and one of the tools we plan to use is the Deift/Zhou steepest descent method to obtain asymptotics for Riemann-Hilbert problems. Although many of the problems in this project have their origin or motivation in mathematical physics, the proposed techniques are mostly based on complex and classical analysis.