RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Biological relevance of the multiple infection unit as a novel target for antiviral development' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The last decade of research in enteric virus infection produced a body of compelling evidences that challenged the paradigm of the single infection unit, where a single virus is able to elicit infection of a target cell. Instead, observational studies of infection in vivo and in vitro suggest that enteric viruses travel in groups: in vesicles with inverted phosphatidylserine topology or at the surface of commensal bacteria. It has been proposed that both strategies increase locally the viral multiplicity of infection, thus favoring viral complementation of defective genomes. There is a lack of knowledge on the biological relevance of the so-called multiple infection unit (MIU) as it has not been mechanistically studied in physiologically relevant model of the GI tract. In addition, the MIU is a strategy employed by all the enteric viruses so far tested, therefore it might represent a valuable target for the design of broad spectrum therapeutics. The central hypothesis of this project is that targeting MIU will inhibit enteric virus infection ex vivo and in vivo. My model of enteric virus is human norovirus (HNoV) for its clinical relevance and for its well described interaction with commensal bacteria. In work package (WP)1, to gain insight on the biological relevance of MIU in ex vivo physiologically relevant models, I will test the hypothesis that MIU increases HNoV infection in human intestinal enteroids. In aim 2, I will develop an in vitro screening platform by pulldown assay with His-tagged HNoV virus-like particles to i) screen for small molecules inhibitors of the infection and ii) identify bacterial species that are bound to HNoV in stool derived from healthy volunteer and diseased patients (i.e. inflammatory bowel disease, Crohn) .  In aim 3, in order to provi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New composite powders for powder coating' (1994-1998).

assistant: **Concept**

1) In the decorative polyester/aluminium system, coatings containing as much as 10 vol% pigment were successfully prepared and displayed final coating qualities better than those currently available. These same coatings also passed the industrial specifications developed for mechanical and corrosion resistance. Unfortunately the commercial exploitation of this powder has not been realised as it was found that during industrial trials that it suffered from both poor application properties as well as poor dry adhesion neither of which could be overcome.2) The production of coatings with high pigmentation levels in the protective polyester - MIO system was optimised at 30 vol%. At this level barrier protection was optimised and produced coatings with good abrasion and very good impact resistance, although their flexibility was low due to the high pigmentation level. Application properties were better than the decorative aluminium powder coating but it was felt by the exploitation committee that this system had limited advantages when compared to other competing powders.3) Mechanical encapsulation at elevated temperature has been successfully used to encapsulate very high pigment loadings in the nylon - zinc system and at the same time retain good application properties. However, poor flow and levelling during stoving leaves the final coatings highly porous and therefore offering no galvanic or corrosion protection.Powder coating is a high quality surface finishing technology used for Many techniques for more sustainable production methods in agriculture are known (organic farming, IPM) and EU and many member states encourage to the use of such techniques. Why then are they not more utilized? And why is there such a heterogeneity in the implementation in the different count
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Improved hydrogen sorption kinetics in new magnesium composites for clean energy storage and transport.' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Mandatory reductions in emission of polluting gases from use of fossil fuel energy in industrial and transport activities are being negotiated between Europe, the USA, Japan and the developing countries and alternative energy sources and devices must be rapidly developed. Metal hydrides offer a safe alternative for transmission and storage of pollution-free hydrogen energy to be used in fuel cells, batteries and other applications. Mg-based metal hydrides with high volumetric energy density, low cost and high abundance are the best candidate but commercialization has been retarded mainly due to high sorption temperatures. In the past two years, research in Canada and Germany have led to breakthroughs in Mg hydride technology by the introduction of small volume fractions of nano-scale mixed-valence oxides such as Cr_2O_3, Fe_3O_4, Mn_2O_3 and V_2O_5 and/or nano-particles of Cr, Fe, Mn, V, Ti, Nb in their metallic states. These innovations, in part achieved and patented by partners in this Network, have reduced H_2 de-sorption times below 300 C to 5 minutes and are considered for application by GFE and other corporations in collaboration with teams of this Network. It is highly original that the most dramatic catalytic effects on H-sorption are generated by nanoparticles of transition metals that are immiscible in Mg and exhibit mixed valency (such as Fe, V, Cr, Mn etc). However, the state of bonding in these nano-particles and their fundamental catalytic mechanisms on the dissociation, Adsorption, diffusion and de-sorption kinetics of H^2 in Mg are not known. It is therefore of urgent fundamental and industrial interest to Perform a comparative study of the effects. This Network proposes to bring together collective pluri-disciplinary expertise from five nations in the E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'An international collaborative study of icsi:child and family outcomes (ICSI-CFO)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Aim: to investigate the implications for family health and the health of children conceived after Intracytoplasmic Sperm Injection (ICSI), a new technology in the treatment of infertility, which is now used in over 750, assisted reproductive clinics in Europe. ICSI conceived children are expected to display the following in comparison with naturally and regular in-vitro-fertilisation conceived children; a greater occurrence of minor physical anomalies, a greater rate of fine/gross motor difficulties and temperamental or behavioural problems. Design: a minimum of 650 British, Belgian, Greek, Swedish, and Danish children born following ICSI will be assessed for cognitive function, psycho-motor co-ordination, behaviour and physical health at age 5 years. Singleton children will be compared with two control populations, matched for socio-demographic factors; one of 500 normally conceived children, and the other 500 conventional IVF conceived children
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EUROPEAN PILOT FOR EXASCALE' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The EUPEX consortium aims to design, build, and validate the first EU platform for HPC, covering end-to-end the spectrum of required technologies with European assets: from the architecture, processor, system software, development tools to the applications. The EUPEX prototype will be designed to be open, scalable and flexible, including the modular OpenSequana-compliant platform and the corresponding HPC software ecosystem for the Modular Supercomputing Architecture. Scientifically, EUPEX is a vehicle to prepare HPC, AI, and Big Data processing communities for upcoming European Exascale systems and technologies. The hardware platform is sized to be large enough for relevant application preparation and scalability forecast, and a proof of concept for a modular architecture relying on European technologies in general and on European Processor Technology (EPI) in particular. In this context, a strong emphasis is put on the system software stack and the applications.Being the first of its kind, EUPEX sets the ambitious challenge of gathering, distilling and integrating European technologies that the scientific and industrial partners use to build a production-grade prototype. EUPEX will lay the foundations for Europe's future digital sovereignty.  It has the potential for the creation of a sustainable European scientific and industrial HPC ecosystem and should stimulate science and technology more than any national strategy (for numerical simulation, machine learning and AI, Big Data processing). The EUPEX consortium – constituted of key actors on the European HPC scene – has the capacity and the will to provide a fundamental contribution to the consolidation of European supercomputing ecosystem. EUPEX aims to directly support an emerging and vibrant European entrepreneuri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'NANORESONATORS WITH INTEGRATED CIRCUITRY FOR HIGH SENSITIVITY AND HIGH SPATIAL RESOLUTION MASS DETECTION' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The aim of the project is to compatibilise well-known CMOS microelectronic technology with novel nanotechnology for the development of new types of high performance nanomechanical sensors. The project is based on a recently developed nanoresonator for mass detection. The sensor is fabricated using novel nanotechnologies, that is, Atomic Force Microscopy (AFM) and laser lithography on metals with resolutions in the nm range. The nanometer-scale dimensions of the nanoresonator will allow extremely high sensitivity and extremely high resolution. CMOS circuit integration will facilitate electrical measurements and it will allow future integration of multiple nanoresonators.The work will focus on:(a) optimising the nanoresonator characteristics and;(b) fabricating a microsystem consisting of the nanoresonator and an integrated circuit, using a CMOS compatible process. The aim of the project is to compatibilise well-known CMOS microelectronic technology with novel nanotechnology for the development of new types of high performance nanomechanical sensors. The project is based on a recently developed nanoresonator for mass detection. The sensor is fabricated using novel nanotechnologies, that is, Atomic Force Microscopy (AFM) and laser lithography on metals with resolutions in the nm range. The nanometer-scale dimensions of the nanoresonator will allow extremely high sensitivity and extremely high resolution. CMOS circuit integration will facilitate electrical measurements and it will allow future integration of multiple nanoresonators.The work will focus on:(a) optimising the nanoresonator characteristics and;(b) fabricating a microsystem consisting of the nanoresonator and an integrated circuit, using a CMOS compatible process.OBJECTIVESThe objective of the overall project is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multicomponent strategy for imaging through a complex near-surface (MUSIC)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Future hydrocarbon availability will depend strongly on our ability to effectively produce from subsurface hydrocarbon reservoirs. Multicomponent seismic data acquisition will play a critical role in the future of reservoir management due to its ability to detect small changes in fluid content and stress in reservoirs over time. However one of the key problems limiting multicomponent data quality is the decorative effect of the near-surface on the deeper reflected wave field. Low velocities combined with strong lateral variation lead to extremely large travertine variations in the deeper reflected wave field. In addition high attenuation and scattering due to strong near-surface heterogeneity impacts amplitudes and recorded waveforms. The research proposed will develop methods to investigate and correct for the decorative effects the near-surface has on deeper reflected data based on the receiver function method from earthquake seismology. The research can be divided into three main parts :(I) Reflectivity and finite-difference modelling of near-surface wave propagation and application of wave field separation techniques to identify the signal observed in recently obtained seismic receiver functions.(II) Extending the receiver function theory from the seismological to the exploration seismic setting. This addresses the effects of non-planar wave fields in seismic as well as shallow mode conversion on reflection opposed to conversion on transmission.(III) Application of the extended receiver function methodology to correct for the decorative effects of the near-surface. This includes a shear-wave static's correction and inverse Q-filtering of the data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Role of CRMP2 and Pin1 in the pathogenesis of Alzheimer’s disease'.

assistant: **Innovation**

Collapsin response mediator protein 2 (CRMP2) is essential for neural development and function. It promotes axon growth but upon its phosphorylation it mediates axon retraction. Deregulation of CRMP2 has been implicated in Alzheimer’s disease (AD) where CRMP2 was detected to form hyperphosphorylated aggregates within neurofibrillary tangles. The mechanisms that regulate formation of CRMP2 aggregates are so far largely unknown. We have recently found that one CDK5-phosphorylated CRMP2 isoform is specifically stabilized by Pin1 - a unique phospho-specific isomerase linked to AD, suggesting that deregulation of Pin1 could contribute to AD related CRMP2 pathology. In the present proposal we will study how various CRMP2 isoforms are involved in CRMP2 aggregate formation and how high levels of Amyloid-b peptide, CDK5, and Pin1 affect phosphorylation, stability or localization of CRMP2 isoforms in AD using mouse models. Funding of the proposal will bring a new insight into the role of Pin1 in AD-related CRMP2 pathology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New Physics for the Large Hadron Collider: new minimal models of composite Higgs' in the context of a Horizon 2020 call.

assistant: **Objectives**

The discovery of the Higgs boson at CERN marks the beginning of a new era in particle physics. After an impressive forty-year search that has ended making Europe the undisputed leader in particle physics, the finding of the long-sought particle offers us the unique possibility of start testing the origin of the electroweak symmetry breaking. In particular, this means that we could be closer than ever to understand some extremely important unsolved puzzles in particle physics, like the large hierarchy between the electroweak and the Planck scales or the origin of fermion masses. Models of composite Higgs are certainly among the best motivated and attractive scenarios trying to address these issues. They also occupy a prominent place in the forefront of theoretical physics, being the object of study of a large community of particle physicists. In this proposal I present an innovative and compelling scenario within this framework where composite leptons, motivated by minimal implementations of leptons featuring a seesaw mechanism of type-III, can partially or fully replace the usual role of the top quark as a trigger of electroweak symmetry breaking without including any anomalously light partner. The presence of custodial symmetry, customary in realistic incarnations of composite Higgs models, ensures that the required sizable degree of compositeness of the right-handed charged leptons is in complete agreement with electroweak precision measurements. These new scenarios offer a beautiful bridge between flavor, neutrino physics and Higgs physics. Throughout this proposal I develop the main objectives and goals of the research proposed, namely, the precise study of lepton flavor constraints in realistic holographic realizations of these models, the study of their implicatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ultra-layered perception with brain-inspired information processing for vehicle collision avoidance' (ULTRACEPT).

assistant: **Innovation**

Autonomous vehicles, although in its early stage, have demonstrated huge potential in shaping future life styles to many of us. However, to be accepted by ordinary users, autonomous vehicles have a critical issue to solve – this is trustworthy collision detection. No one likes an autonomous car that is doomed to a collision accident once every few years or months. In the real world, collision does happen at every second - more than 1.3 million people are killed by road accidents every single year. The current approaches for vehicle collision detection such as vehicle to vehicle communication, radar, laser based Lidar and GPS are far from acceptable in terms of reliability, cost, energy consumption and size. For example, radar is too sensitive to metallic material, Lidar is too expensive and it does not work well on absorbing/reflective surfaces, GPS based methods are difficult in cities with high buildings, vehicle to vehicle communication cannot detect pedestrians or any objects unconnected, segmentation based vision methods are too computing power thirsty to be miniaturized, and normal vision sensors cannot cope with fog, rain and dim environment at night. To save people’s lives and to make autonomous vehicles safer to serve human society, a new type of trustworthy, robust, low cost, and low energy consumption vehicle collision detection and avoidance systems are badly needed.This consortium proposes an innovative solution with brain-inspired multiple layered and multiple modalities information processing for trustworthy vehicle collision detection. It takes the advantages of low cost spatial-temporal and parallel computing capacity of bio-inspired visual neural systems and multiple modalities data inputs in extracting potential collision cues at complex weather and l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ageing Multiphysics of Asphalt Materials' (AMAM).

assistant: **Innovation**

The ultimate objective of this fellowship, entitled “Ageing Multiphysics of Asphalt Materials (AMAM)”, is to intensively train a talented researcher, Dr Fan Gu, through an interdisciplinary project focused on the modelling of the ageing multiphysics and performance evaluation of asphalt materials. Deliverables including fundamental understanding of asphalt ageing multiphysics, novel anti-ageing materials and a systematic performance prediction framework for engineering applications in sustainable design, construction, and maintenance of road infrastructures. The Fellow will receive intensive technical training in multidisciplinary field of chemistry (Aston), material science (Aston), computational modelling (Aston, TUD), experimental characterisation (NTEC) and industry applications (Nynas and AI). The Fellow will also receive inter-sector professional skills training in project management, organization and networking. The project outputs will enhance the EU scientific excellence by exploring the ageing mechanisms of complex bitumen-based materials, strength the EU industry leadership in anti-ageing material innovation, and protect EU environment and natural resources through extended service life of the aged road infrastructures using innovated recycled/bio-based anti-ageing construction materials. Uniquely, the project will enable the Fellow to an independent leading researcher in infrastructure engineering for his academic career and to become a rare asset to European research through leading the research and building effective collaboration network among academia and industry.