RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The interaction landscape between microbial colonization and functional genome of the host: a systems biology approach in fungal infections' in the context of a Seventh Framework call.

assistant: **Objectives**

Fungi such as Candida albicans are ubiquitous colonizers of human skin and mucosa. Fungal pathogens invade the host when host defence is diminished, and the combination of fungal and bacterial colonization modulates mucosal and systemic immune responses. Little is known of the complex interaction between fungal and bacterial colonization, as well as between these two and the host genome and immunity. The Hypothesis of this proposal is that immunity to C. albicans is determined by the interaction between fungal colonization (mycobiome), bacterial flora (bacteriome), and the genetic background of the host (genome). This interaction is distorted in patients with fungal infections, and the identification of these imbalances will lead to novel therapeutic targets.The Key Objectives are:1) To map the landscape of interaction between the fungal colonization (mycobiome), bacterial flora (bacteriome) and the genetic and immunological make-up of the host (functional genome).2) To assess the dysregulation of these interactions in patients with the two most important Candida infections: recurrent vulvovaginal candidiasis (RVVC) and disseminated candidiasis.Methodological approach:- the mycobiome and bacteriome will be determined on the skin and mucosal surfaces of healthy volunteers, RVVC and disseminated candidiasis patients.- functional assessment of antifungal immune mechanisms will be correlated with the mycobiome/bacteriome, and with the host genetic variation (genome).- validation of the functional interactions of microbial communities with host immunity using focused genotyping and follow-up pathway activity screening in human cell cultures and experimental models.- microbiome/functional genome dysregulation between healthy individuals and patients with muocosla and systemic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Achieving Sustainability by using Substitutive Information Society Technologies' (ASSIST).

assistant: **Concept**

ASSIST is a study addressing a key issue in the contribution of IST to sustainability, that of the potential for the substitution of IST analogs for material consumption (virtualisation or immaterialisation). Most consumption is unrelated to basic needs but is to satisfy non-material needs. Consumption substitution by IST thus offers a powerful route to sustainability. However, design of substitution techniques necessitates both a good knowledge of the reasons for consumption and -inter alia- of the sensory and ontological aspects of IST. ASSIST's objective is to contribute to IST by surveying existing multi-and cross-disciplinary work in the area, making recommendations for future work and proposing new parameters for product and service design.The work includes:Firstly, a state-of-art survey by expert interviews and by targeted questionnaire including a multi-disciplinary workshop to identify the extent and progress of related work.Secondly, reasoned analysis and classification of the state-of-art including mapping across the needs and satisfiers issues underlying consumption against the IST e-work and e-business issues that may have the potential for consumption substitution. This task will also include a multi-disciplinary workshop reviewing potentials for new RDT actions and relevance for product and service design.Finally, the outcomes will be presented at a Conference making concrete recommendations for the definition of future RTD actions in promoting sustainability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Global Online Science Labs for Inquiry Learning at School' in the context of a Seventh Framework call.

assistant: **Objectives**

The Go-Lab project will open up remote science laboratories, their data archives, and virtual models (online labs") for large-scale use in education. Go-Lab enables science inquiry-based learning that promotes acquisition of deep conceptual domain knowledge and inquiry skills and directs students to careers in science.For students (10 to 18-years old), Go-lab offers the opportunity to perform personalized scientific experiments with online labs in pedagogically structured and scaffolded learning spaces that are extended with social communication facilities.For teachers, Go-Lab offers pedagogical "plug, share, and play" through a Web-based interface and a community framework to disseminate best practices and find mutual support. A modular approach and inquiry classroom scenarios promote a seamless incorporation of online labs into the classroom.For lab-owners, Go-Lab provides open interfacing solutions to easily plug in their online labs, construct their virtual didactic counterparts, and share them in the Go-Lab federation of online labs. Go-Lab will thus promote their scientific activities.The project starts with a set of online labs from worldwide renowned research organisations (e.g., CERN, ESA) and then from selected universities and, based on initial in-depth pilots, will gradually improve and expand its series of online labs and associated inquiry learning opportunities with the increasing contribution of teacher and lab-owner communities. More advanced and later versions will be evaluated and validated in large scale pilots.The Go-Lab project throughout Europe will expand the resources for teaching science in schools and provide more challenging, authentic and higher-order learning experiences for students. Its sustainability will come from the opportunity for th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A roof integrated solar tile system to develop cost-effective distributed solar power generation.' in the context of a Horizon 2020 call.

assistant: **Objectives**

Soltiles have developed a cost-effective roof integrated solar tile system that encourages easy adoption of renewable energies and the spread of green building approach. The solar industry is limited to a central power generation model, the proposed solar tiles (soltiles) will assist in the development of the distributed grid. Current PV modules require large panels and often complex installation; it is also a very capital intensive process. Soltiles proprietary technology minimises power generating costs for the property owners whilst improving aesthetics of the buildings. Soltiles’ initiative is a tile installed onto roofs like a standard roofing tile. Installation can be undertaken by any roofing contractor. The integrated solar slate is unique by incorporating both crystalline and thin film technology. The thin polymer composite membranes improve flexibility and versatility of the substrate, while the PV cells used have 20+% efficiency. The technology has been experimentally validated and the soltiles have been proven to yield more than 90% of the absorbed energy from the PV cell. Soltiles targets the residential and re-roofing markets to promote the development of Net Zero Energy Homes.The Phase 1 project will be focused on establishing a complete supply chain, a sound business model and commercialization strategy and to plan all activities for deploying a pilot production line of 5000 soltiles to serve the in-field installation of about 200 roofs in the EU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'MOBILE ROBOTICS TECHNOLOGY for HEALTH CARE SERVICES RESEARCH NETWORK' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The aim of the proposed research network is to establish and organise, in a expertise within the workgroup of researchers, with special emphasis on formal cooperative status, an active workgroup of researchers in the newly introduced field, of the mobile robotics technology and health care the provision of high level education to the visiting researchers. The services. training content includes courses from Mobile Robotics Technologies, Rehabilitation Technologies and Health Care Services. The courses are Training of young post-doctoral scientists is in the focus of the network, targeting post-doctoral researcher with strong commitment in the field. while it will be project/prototype oriented, offering vertical knowledge of one discipline to scientists of other disciplines. The outcome of the project will be the detailed design of the prototype of an autonomous mobile platform with high maneuverability and manipulability features. This prototype design will be the final deliverable, integrating the innovative, research results. Operational features of the robot will include execution of complicated manipulation and transport tasks, in fully autonomous operation. The behaviour of the robot will be optimised for indoor health care tasks. The network will address a wide range of topics beyond the state of the art, such as: hierarchical task planning, intelligence distribution and organisation, real time control of multi joint/wheels robots, path planning and obstacle avoidance methods for structures with complicated kinematics constraints, sensor fusion of 1D to 3D information, environment perception, representation and modelling techniques, adaptive man-machine interface, etc. The proposed network is consisting of 12 partners from 9 European countries. There is delegation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Assay-Ready Organ Network' (ARON) targeting Horizon 2020.

assistant: **Abstract**

In drug development, there is an urgent need for more physiological and predictive pre-clinical in-vitro assays to test the efficacy and toxicity of compounds. This to allow new medicines to be brought to the market quicker and safer. With the growing biological complexity of today’s diseases, it is vital to have interconnected 3D tissue structures of multiple organs in order to investigate biological cross-talk. Today, such physiological and predictive pre-clinical in-vitro assays are not available.Here, InSphero presents ARON, their Assay-Ready Organ Network, to address the urgent need for more physiological and predictive pre-clinical in-vitro assays and aims to study the feasibility of a successful market introduction. ARON is the most advanced modular in-vitro assay platform and will set a new standard for a wide range of cell-based pre-clinical testing by shifting the organ-on-a-chip technology from a late-stage, luxury service to routinely used ready-to-use assays. This enables pharma and biotech companies to develop drugs in a faster and more efficient way, without the use of animals. All elements and process steps guarantee routine implementation for everyone, while experimental complexity is minimized. ARON has the unique option that the consumables are assay-ready, directly shipped on-site, on-demand, and worldwide.InSphero is a leading supplier of organotypic in-vitro 3D microtissues for predictive drug testing and has grown yearly by 40% in the past years. ARON will turn today's service possibilities into a scalable product and will enable to offer assays for highly competitive pricing. The (USA dominated) 3D tissue market is expected to grow with CAGR of 63% to reach a market size of 1.5 billion EUR in 2024. A successful market introduction will impact the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Next-Generation Cognitive Testing: A Theory-Driven Approach to Multi-Scale Dynamics in Cognition', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Few aspects of human performance are as salient and consequential as its variability. Fluctuations are evident in essentially all areas of cognition. For example, attention fluctuates with alertness modulated by circadian timing, while cognitive abilities change over longer time scales due to skill acquisition and forgetting. Given the critical role of cognition in nearly all aspects of human functioning, including safety-critical situations, these fluctuations have profound implications. Yet, the causes and temporal scales of cognitive fluctuations remain poorly understood due to fragmented research efforts focusing on isolated psychological and biological factors. Here I will develop a unified theoretical framework, for the first time synthetizing the dynamics of the diverse factors underlying fluctuations in cognitive abilities across multiple temporal scales. This interdisciplinary approach will create new opportunities for the emerging field of ecological momentary assessment (EMA) in cognitive testing, enhancing reliability and predictive power, and advancing understanding of cognitive dynamics in real-world contexts. The project includes two synergistic strands: (1) Theoretical work to create a dynamic quantitative modeling framework, linking accounts of short-term variability to longer-term adaptations in performance; (2) Empirical work using EMA to investigate how and why performance on a wide range of cognitive tasks fluctuates across time scales from sub-seconds to several weeks. The innovations are fuelled by recent advances in formal cognitive modeling and the development of powerful Bayesian hierarchical techniques. My objective is to drive a paradigm shift from traditional lab-based assessments to real-world evaluations of cognitive abilities and pave the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Switch recombination: a model system for DNA editing and repair in human lymphocytes with relevance for primary immunodeficiency and cancer formation' to be submitted under Seventh Framework.

assistant: **Abstract**

The aim of this project is to try to understand the complex molecular mechanisms involved in DNA editing, repair and recombination during immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM). We have developed a series of PCR-based assays to study in vivo generated CSR junctions and the pattern of mutations introduced in the immunoglobulin variable region genes in human B cells, allowing us to characterize CSR and SHM in patients with immunodeficiency due to defect(s) in DNA repair/recombination. Novel in vitro CSR assays, based on GFP expression, allowing quantitative measurement of substrate recombination, are also being developed. In addition, we have initiated an evolutionary analysis of the function and structure of activation-induced deaminase, an essential molecule involved both in CSR and SHM, aiming to identify CSR specific-cofactor(s). Combining these approaches, we will be able to define the DNA repair pathways involved in CSR and SHM. The suggested project requires access to patients with various defects in the DNA repair pathways. Many of these diseases are exceedingly rare. However, through worldwide collaboration, we have obtained samples from a majority of the diagnosed patients. We are also refining the existing screening methods and developing novel methods, that will allow identification of additional patients both with recognized and new diseases caused by mutations in DNA repair pathways. Finally, we hope to be able to address the question whether illegitimate CSR events are associated with predisposition to lymphomagenesis in patients with immunodeficiency/DNA repair defect(s), by analyzing the CSR induced chromosomal breaks and translocations in these patients. A large-scale sequencing project is also planned to characte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Counterfactual Assessment and Valuation for Awareness Architecture' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The Counterfactual Assessment and Valuation for Awareness Architecture (CAVAA) project proposes that awareness serves survival in a world governed by hidden states, to deal with the “invisible”, from unexplored environments to social interaction that depends on the internal states of agents and moral norms. Awareness reflects a virtual world, a hybrid of perceptual evidence, memory states, and inferred “unobservables”, extended in space and time. The CAVAA project will realize a theory of awareness instantiated as an integrated computational architecture and its components to explain awareness in biological systems and engineer it in technological ones. It will realize underlying computational components of perception, memory, virtualization, simulation, and integration, embody the architecture in robots and artificial agents, validate it across a range of use-cases involving the interaction between multiple humans and artificial agents, using accepted measures and behavioural correlates of awareness. Use cases will address robot foraging, social robotics, computer game benchmarks and human-generated decision trees in a health coach. These benchmarks will focus on resolving trade-offs, e.g. between search efficiency and robustness, and assess the acceptance of human users of aware technology. CAVAA’s awareness engineering is accompanied by an ethics framework towards human users and aware artefacts in the broader spectrum of trustworthy AI, considering shared ontologies, intention complementarity, and behavioural matching, an empathy, relevance of outcomes, reciprocity, counterfactuals and projections towards new future scenarios, and to predict the impact of choices. CAVAA will deliver a better user experience because of its explainability, adaptability, and legibility
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for '(Inter-)nationalism and the new Turkey: the rise and fall of international education at Istanbul's Robert College, c. 1913-1933' under Horizon 2020.

assistant: **Concept**

The purpose of this project is to analyze the conflicts and strategies of adjustment emanating from the encounter of international education, seeking to overcome national bias, with nation building efforts in post-Ottoman Turkey. Efforts to imbue students with a sense of internationalism in the aftermath of WW1 had to be reconciled with those of emerging nation states. Using the case of Robert College, an American private institution in Istanbul, which aimed to foster a future social and political elite of a native student body drawn from different ethnic and religious communities in Turkey, I will shed light on an understudied aspect of Turkish nationalism and education in the early Kemalist era, namely the relation between this institution's internationalist ideals and the tenets of a Westernizing yet ethnocentric national ideology. The never before analyzed material is drawn from the archives of Robert College as well as private collections of its teaching staff. Using this material, I will address the educational philosophy and intentions of the faculty, the strategies and arguments developed in its dealings with Turkish authorities, and the reasons for the demise of international education in Turkey as well as students' understanding of internationalism, patriotism and modernization. This is a perspective that has been largely absent in scholarship on this critical phase of modern Turkish history, owing to the hegemony of Kemalist discourse during the interwar years. The project thus contributes new knowledge and a more nuanced understanding of the roots of the current AKP government's backlash against ""Western"" modernity, and the continuity between today's Islamist traditionalism and the alleged secularism of Kemalism, with regard to tolerance of ethnic and reli