RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Development of a modular, integrated and autonomous ‘Factory-in-a-box’ production line for manufacturing high volumes of Flexible integrated LogIC circuits'.

assistant: **Innovation**

Our Flexible Integrated Circuits (FlexICs) are recognised by the likes of ARM as a disruptive innovation that will change the formation of the semiconductor industry significantly. We are PragmatIC Printing Ltd, pioneers of design, development and manufacture of non-silicon ICs on plastic. Our FlexICs are; thinner than a human hair; ultra-flexible and offered in flattering form factors and footprints that conventional silicon cannot offer. Our processes allow FlexICs to be produced on a large scale at a low cost; the marginal cost per IC in volume production can be <€0.1c. Non-silicon ICs bring many new potential market applications previously unattainable with conventional technology. FlexICs that are visually unobtrusive are ideal for integration onto goods packaging, controlled documents, and others. During Phase 1, we validated the market potential for our FlexICs. A conservative estimate shows a demand for 800bn FlexICs p/a, which is a fraction of the full 40trillion p/a potential.In order to facilitate this demand, we want to enable localised FlexIC production capacity for packagers, integrators and component manufacturers for immediate integration into end-products. Our solution is to develop a ‘factory-in-a-box’; a self-contained, modular and autonomous production facility containing all of our novel processes. This FlexLogIC plant will deliver the FlexICs required cost effectively at market accepted price levels. We have strong documented need and demand pull from market leading companies such as Crown Packaging, Cartamundi, Molex and SMARTRAC and others for an integrated solution such as FlexLogIC.Within 2 years, we will develop an entry-level module (ELMo) with capacity to produce upto 800m FlexICs p/a. The 5-year forecasts conservatively show a net cash infl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Open Flow in Europe: Linking Infrastructure and Applications'.

assistant: **Concept**

The aim of the OFELIA project is to create a unique experimental facility that allows researchers to not only experiment 'on' a test network but to control the network itself precisely and dynamically. To achieve this, the OFELIA facility is based on OpenFlow, a currently emerging networking technology that allows to virtualize and control the network environment through secure and standardized interfaces. In a nutshell, OpenFlow enables experimenters to change the behavior of the network as part of the experiment rather than, if at all, as part of the experiment setup. OFELIA will provide high-performance OpenFlow equipment to enable experiments at scale and to ensure that the facility is based on mature technology.<br/>Another strength of OFELIA is its concept of federated or interconnected islands. A set of five islands creates a diverse OpenFlow infrastructure that allows experimentation on multi-layer and multi-technology networks provided by the different islands. The facility will extend all the way from standard Ethernet to optical and wireless transmission and it will also include an emulation wall for scalability tests comprising thousands of nodes.The facility will grow in three phases to, on the one hand provide an early access to the facility (after 6 months already) and, on the other hand to evolve during the project lifetime, incorporating the feedback of the user community and extending its reach to other test facilities. Two open calls will be published to invite experimenters that bring their use cases and scenarios to the facility creating a feedback loop to extend the OFELIA facility according to the needs of the user community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The role of three-dimensional genome architecture in antigenic variation' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Antigenic variation is a widely employed strategy to evade the host immune response. It has similar functional requirements even in evolutionarily divergent pathogens. These include the mutually exclusive expression of antigens and the periodic, nonrandom switching in the expression of different antigens during the course of an infection. Despite decades of research the mechanisms of antigenic variation are not fully understood in any organism.The recent development of high-throughput sequencing-based assays to probe the 3D genome architecture (Hi-C) has revealed the importance of the spatial organization of DNA inside the nucleus. 3D genome architecture plays a critical role in the regulation of mutually exclusive gene expression and the frequency of translocation between different genomic loci in many eukaryotes. Thus, genome architecture may also be a key regulator of antigenic variation, yet the causal links between genome architecture and the expression of antigens have not been studied systematically. In addition, the development of CRISPR-Cas9-based approaches to perform nucleotide-specific genome editing has opened unprecedented opportunities to study the influence of DNA sequence elements on the spatial organization of DNA and how this impacts antigen expression.I have adapted both Hi-C and CRISPR-Cas9 technology to the protozoan parasite Trypanosoma brucei, one of the most important model organisms to study antigenic variation. These techniques will enable me to bridge the field of antigenic variation research with that of genome architecture. I will perform the first systematic analysis of the role of genome architecture in the mutually exclusive and hierarchical expression of antigens in any pathogen.The experiments outlined in this proposal will provide new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Synergistic integration and efficient operation of thermochemical energy storage-assisted magnesium hydrides-based hydrogen storage systems' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Currently, global energy consumption is growing rapidly, but over-reliance on fossil energy poses significant risks to the global ecosystem. It is urgent to establish a clean, safe and sustainable energy supply system. The large-scale development of green hydrogen energy is a key solution to address the challenges of greenhouse gas emissions and global climate change. However, its large-scale utilization requires the development of safe, reliable and convenient methods for hydrogen storage and transportation. Among the many hydrogen storage technologies, solid-state hydrogen storage technology based on magnesium hydrides (MgH2) stands out with its significant advantages, such as high hydrogen storage density (7.6wt%) and high operational safety. However, their high energy consumption in the dehydrogenation processes makes them less economical in practical scenarios. Therefore, this project will focus on synergistic integration and efficient operation of thermochemical energy storage-assisted MgH2-based solid hydrogen storage (TCES-MgH2) system to enhance energy efficiency in the hydrogen supply chain and reduce hydrogen storage costs. This project will combine mechanism analysis, numerical simulation and experimental research to select the most suitable TCES material to assist magnesium hydrides in absorbing and releasing hydrogen. It will use long short-term memory neural networks, heuristic algorithms, and model predictive control to optimize heat transfer structures and control strategies of the hydrogen storage system, achieving rapid heat transfer and efficient hydrogen desorption/absorption. Additionally, it will assessment the large-scall deployment potential of the TCES-MgH2 system by machine learning. The outcomes of this research will provide pivotal technolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Deciphering the melanoma-niche cell interplay to identify novel treatments for metastatic melanoma'.

assistant: **Concept**

Metastasis is the leading cause of death among patients with solid tumours including melanoma, the most serious type of skin cancer. Despite tremendous progress in the development of effective targeted and immunotherapies, patient survival is still low. Understanding the mechanisms regulating the dissemination of cancer cells is critical to uncover new vulnerabilities of aggressive tumours. Whilst previous research has mostly focused on cell-intrinsic properties of cancer cells, the aim of this project is to define the impact of signals from the cancer cell niche on melanoma dissemination in vivo, with the long-term goal of discovering drug targets and developing new pharmacologic strategies against metastatic melanoma. Building upon previous results from the Ablain laboratory, I will elucidate and target the mechanism by which melanoma cells change their adhesion properties in response to local IGF1 signalling. Additionally, new interactions between melanoma cells and niche cells will be identified by scRNA-seq in human metastatic melanoma tissue obtained from the HCL Hospital, and recapitulated in reconstructed human skin systems and in zebrafish models. I will investigate the role of these interactions in the regulation of melanoma cell behaviour by combining genetic and pharmacologic manipulation with cutting-edge live-imaging in vitro and in vivo. This fellowship, through advanced interdisciplinary and intersectoral training and collaborations, will serve as a launchpad for reaching a position of academic independence, whilst facilitating a transfer of knowledge between myself, the CRCL and several collaborators, and addressing an unmet need for a better understanding of the behaviour of aggressive tumours. I will use this award to expand my skillset, build an inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pro-sumer AwaRe, Transactive Markets for Valorization of Distributed flexibilITY enabled by Smart Energy Contracts' (PARITY).

assistant: **Concept**

PARITY addresses the “structural inertia” of existing distribution grids by delivering a transactive grid & market framework that will increase the durability and efficiency of the electrical grid and facilitate the penetration of RES beyond 50% of the generation mix in the distribution network.PARITY will go beyond the traditional “top-down” grid management practices by delivering a unique local flexibility market platform through the seamless integration of IoT and blockchain technologies. By delivering a market for automated flexibility exchange based on smart contracts & blockchain, PARITY will facilitate efficient and transparent local flexibility transactions and reward flexibility in a cost-reflective and symmetric manner, through price signals of higher spatio-temporal granularity based on real-time grid operational constraints and available DER flexibility. Secondly, by deploying State-of-the-Art IoT technologies PARITY will offer distributed intelligence (DER profiling) and self-learning/self-organization capabilities (automated real-time distributed control), orchestrated by the cost-reflective flexibility market signals generated by the blockchain market platform. Within PARITY, DERs will form dynamic clusters that essentially comprise self-organized networks of active DER nodes that will efficiently distribute and balance global and local intelligence, enabling real-time aggregated & P2P transactions through enhanced forecasting, optimization and control of DER flexibility. Finally, the PARITY solution includes novel tools for Active Network Management, including an innovative STATCOM and PQ monitoring device, that will enable the DSO to enhance its management capabilities, grid observability and RES hosting capacity.The PARITY solution will be demonstrated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Predicting flame acceleration and deflagration to detonation transition in industrial scale explosions incorporating the turbulence effects' to be submitted under Horizon 2020.

assistant: **Abstract**

Statistics show that fires and explosions are the top cause of Business Interruption loss. Despite increasingly stringent safety measures, explosions continue to occur with higher frequency and consequences especially when Deflagration to Detonation Transition (DDT) occurs. Flame acceleration (FA) and DDT involve complex physical and chemical processes. Current provisions for explosion safety design are based on mechanisms for explosives and insufficient to interpret the complex nature of gas explosions. Their use in safety design is problematic.    DNS predictions have shown the importance of TF on FA and DDT in uniform mixtures. Such influences are likely to be even more profound in mixtures with concentration gradients and when obstacles are present. There lacks experimental and numerical investigations to shade light on this. Robust and efficient predictive techniques which can capture global safety features associated with FA and DDT as well as TF are also missing. TurbDDT aims to fill these knowledge gaps. It aims to predict FA and DDT in industrial scale explosions incorporating the turbulence effects. The specific scientific objectives include: 1. To gain insight of TF on FA and DDT in smooth channels/tubes with uniform mixtures and mixtures with concentration gradients using DNS;2. To repeat the above in channels/tubes with obstacles;3. To assess the capability of the compressible linear eddy model in large eddy simulations (CLEM-LES) for medium scale simulations and compressible reactive solver (CRS) for large scales; 4. To conduct large scale FA and DDT of practical scales and assess the resulting differences in the predicted likelihood of DDT and explosion impact on structures when the more efficient CRS approach is used; and to draw conclusions and guidelin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Rev.E. Revolution and Empire. Evolution of the dramatic art and cultural policies between the end of French Revolution and the Imperial era'.

assistant: **Concept**

Due to its double nature (text and representation) theatre belongs to the literary domain while having specific aspects that binds it to its socio-historical context. During the considered era it is one of the most effective collective expressions of society. Its analysis allows a still topical reflection on institutional mechanisms of control of the freedom of art and press. Conceived with Prof. Astbury (University of Warwick host institution) and Prof. Frantz (Université Paris-Sorbonne secondment) Rev.E project has 2 objectives. First, the creation of a missing calendar of the Parisian repertory of the Consulate (1799-1804) related to a freely accessible online database (filled with unknown primary materials: press reviews, censors' or police reports etc.) that will be combined with an interactive website to allow a user-friendly gateway to explore it. Second, the investigation of the relationship between theatre and its broader context (1789-1815) to enhance critical reflection on a neglected corpus through an interdisciplinary approach (arts de la scène, history, history of theatre and of literature, history of mentalities, cultural policies). Findings will also be presented through themed seminars, an international conference (plus volume of proceedings), academic presentations, the submission of 3 articles to peer-reviewed journals and of the critical edition of Etéocle by Legouvé (1799). Public engagement activities for a non-specialist public will include talks (Coventry, 2021 Uk city of Culture), an online exposition (Costuming the Consulate), a school workshop leading to an online theatrical chronicle (1799-1804, key-dates) using tweets and radio interviews, and the staging of La femme à deux maris (Pixérecourt, 1802) at Porchester Castle. The collaboration wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The development of immuno tests for specified risk material (SRM TEST)' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The presence of Bovine brain spinal cord eyes and tonsils (SRM) in meat products is strictly controlled under EU legislation to protect European consumers, but there are no adequate methods for policing such legislation, especially where the products are sterilized. The goal of this project is to develop rapid immunoassays in ELISA and Lateral Flow field kit systems, to detect specific SRM components. Tissue specific peptides will be identified using bioinfomatics and synthesized also peptide extracts of SRM will be prepared and affinity purified before being used as immunogens . These extracts and peptides will be used for the development of antibodies for these assays. Assays will be validated and used in a survey of European meat products. Results will be disseminated through publication in trade scientific journals and through the internet .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Robust, and FLEXible CAST iron manufacturing' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The FLEXICAST project presents knowledge-based technologies that aim to follow the way to transform the conventional (batch-by-batch) foundry process into a flexible (mold-by-mold) process. The proposal technologies will be applicable not only to new cast iron foundry lines, but also is readily available to be retro-fitted to existing plants. The specific objectives are:a)A cast iron production cell. Together with melting, treatment and pouring sub processes in a cast iron production cell is essential and imperative.  We propose to install the melting shop closer to the pouring system kept closed on the mould carrousel, while the transfer and treatment ladle is removed. The widespread adoption of new melting shop as an operating process is in itself fostering the creation of even more powerful induction-plasma power supplies, versatile melt control technology, high-power density furnaces, temperature control systems, nodularization systems(magnesium vapour), inoculation systems, and automated pouring systems.b)Integration of Artificial Intelligence-based Control System. The objective is to develop a software platform. This can help us to the prediction of local structures, phases and ultimately the local mechanical properties, to asses casting quality in the foundry. In this point, also, three specific methodologies will be studied and improved:DTA analysis and on-line microstructural analysis and X-ray for on-line inspection.c)A robot cell for automated metal finishing processes. d)Demo pilot plant in real industrial settings in order to demonstrate a clear breakthrough using project development in comparison with the state-of-art solutions. Some results are:a)Cast iron manufacturing cell represents, at least, 30% energy reduction in comparison with conventional meltin