RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Noninvasive Modulation of the Blood Brain Barrier using PiezoMagnetic Carbon Nanoneedles'.

assistant: **Innovation**

Abstract The Blood Brain Barrier (BBB) protects the brain from unwanted chemicals and provides a precisely regulated microenvironment to function normally. However, this defense barrier presents a challenge in shuttling therapeutic cargoes into the brain for the treatment of brain tumours and neurodegenerative diseases. To date, the known methods for BBB penetration poses inherent limitations which are often dangerous to the patients including the microbubble mediated ultrasound (US) driven BBB penetration.  Herein we propose an innovative strategy to cross the BBB by introducing PiezoMagnetic Carbon Nanoneedles (PMCNNs) and evaluate its potential as an ideal brain drug delivery system (DDS). PMCNNs are made of functionalised carbon nanotubes (ƒ-CNT) decorated with PiezoMagnetic Nanoparticles. Due to the intrinsic piezoelectric property of PMCNNs, they convert short wave ultrasound (US) into electric pulses to electrically permeate the BBB noninvasively which is not possible by any of the known techniques so far. The main objectives of PiezoMagBBB are 1) to electrically permeate an in vitro BBB model with PMCNNs through nano-electroporation under short wave US and 2) to assess the efficacy of PMCNNs to deliver anticancer therapeutics in 3D tumour spheroids and brain tumour organoids. Thus PiezoMagBBB will design novel PMCNNs; assess their cytotoxicity in different brain cells; evaluate their BBB modulation under US and cellular uptake in BBB models; investigate their potential as a DDS for anticancer drugs in “in vivo tumour mimicking” glioblastoma spheroids and brain-tumour organoids. The fellow brings her extensive expertise in smart DDS design to the host lab, which in turn will offer world-class biological and nanotoxicological facilities and nanomedicine expertise.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Deep Earth Chemistry of the Core' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Core formation represents the major chemical differentiation event on the terrestrial planets, involving the separation of a metallic liquid from the silicate matrix that subsequently evolves into the current silicate crust and mantle. The generation of the Earth’s magnetic field is ultimately tied to the segregation and crystallization of the core, and is an important factor in establishing planetary habitability. The processes that control core segregation and the depths and temperatures at which this process took place are poorly understood, however. We propose to study those processes. Specifically, the density of the core is lower than would be expected for pure iron, indicating that a light component (O, Si, S, C, H) must be present. Similarly, the Earth’s mantle is richer in iron-loving (“siderophile”) elements, e.g, V, W, Mo, Ru, Pd, etc., than would be expected based upon low pressure metal-silicate partitioning data. Solutions to these problems are hampered by the pressure range of existing experimental data, < 25 GPa, equivalent to ~700 km in the Earth. We propose to extend the accessible range of pressures and temperatures by developing protocols that link the laser-heated diamond anvil cell with analytical techniques such as (i) the NanoSIMS, (ii) the focused ion beam device (FIB), (iii) and transmission and secondary electron microscopy, allowing us to obtain quantitative data on element partitioning and chemical composition at extreme conditions relevant to the Earth’s lower mantle. The technical motivation follows from the fact that the real limitation on trace element partitioning studies at ultra high-pressure has been the grain size of the phases produced at high P-T, relative to the spatial resolution of the analytical methods available to probe the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Technology transfer of Remotely Piloted Aircraft Systems (RPAS) for the creative industry' (RPAS) under Horizon 2020.

assistant: **Objectives**

Aerial photography and filming represent an indispensable resource for the Creative Industries (CIs). When filming in indoor environments, auxiliary devices as cable cams, camera rails, jibs, scaffolds or lifting platforms are being employed, enabling to realize special aerial camera shots.  With the rise of Remotely Piloted Aircraft Systems (RPAS), commonly known as drones, CIs are increasingly focusing on its use outdoors, providing significant advantages over current photography and filming techniques such as widening the creative possibilities and freedom of camera movement, less invasive and risky compared to auxiliary devices and affordable.However, RPAS cannot be professionally employed indoors by the CIs. Existing RPAS lack of a precise, robust and affordable indoor positioning system (IPS) as well as advanced safety features. Without a good IPS the control of the RPAS in indoor environments is particularly difficult and even unsafe. Currently, there are three IPS suitable for RPAS, but these are too expensive (€200k), or present large limitations (e.g. sensitive to light conditions) for its usage by CI SMEs. This jeopardizes the creative possibilities of CI and their competitiveness.Hence, the main goal of AiRT project is to provide the European CI SMEs a tool that, by expanding their creative spaces will help them to offer new services, which in turn will increase their changes to grow within the European and international market. To accomplish this objective, AiRT project will develop the world´s first indoor RPAS specifically designed for professional use by the CIs.As a result, over 900.000 European CI firms will benefit from the transfer of the latest advances in IPS, 3D scene reconstruction, navigation and active / passive safety measures into an intellig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cooperative approach to air traffic services II' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

In the FP6, the European Commission is proposing a paradigm shift in the way air traffic services are provided. The overall objective is to achieve the Single European Sky and Eurocontrol's ATM2000+ Strategy. An ATM concept is a potential solution for a problem identified in ATM. The development of an ATM concept has a life cycle in which the concept has a maturing process.The CAATS project identifies the E-OCVM as the best Concept Validation Methodology as it can be seen to be the most applicable to the first three phases from the AP5 maturity model (the Operational Concept Validation Strategy Document developed by FAA/Eurocontrol proposes a five level concept maturity scale). In this process the stakeholders make decisions about the progress of the concept, based on its maturity, beyond the world of ATM R&D.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'RESEARCHERS' NIGHT 2009 IN NORWAY' (RES-NIGHT-NOR-2009) targeting Seventh Framework.

assistant: **Abstract**

As in the successful “Researchers’ Night” (RN) projects in Norway 2005-2008, our RN 2009 is planned as a nation-wide promotion effort in line with the objectives of the ERA Green Paper 2007, the Lisbon Council, the Ljubljana Process and the call FP7-PEOPLE-NIGHT-2009 - organised as add-on to the coinciding “Forskningsdagene” (Norway’s National Science Week 18.-27. Sept 2009 with 1000 events by 200 local organisers all over Norway, coordinated by the Research Council of Norway (RCN). The RCN submits this coordinated proposal from Norway proposing 15 subcontracted local events selected after national competition. Local and RCN co-financing are substantial. In this nationwide effort researchers are directly involved in informal contact, dialogue and collaboration with the public at large (kids, teenagers, adults and parents, teachers, entrepreneurs, politicians…), well covered by the media. Focus is on the contribution of research and researchers to the society at large, to “de-mystify” research, show that researchers are ordinary people, and how interesting it is to be a researcher. Events include ”hands-on” lab experiments, interactive settings, night in aquarium, cod aquaculture, research vessel study tour, planetarium, Gründer camps – all featuring ”real science”. Industrial partners and EU-supported researchers are included. Professionals will be invited to join the RN 2010 poster competition where winners are selected by public voting on the RCN website www.rcn.no prior to the Night’s award/exhibition ceremony at the RN Darwin Anniversary event in Oslo. The European Corner stand will be at the NTNU Open Lab event in Trondheim. We hope to match RN 2008 when awareness campaigns by nationwide newspaper inlets, advertisements, emails, web-site information, and media cove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Precision control of glycosylation to open a new era of therapeutic antibodies' (GlycoBoost) targeting Horizon Europe.

assistant: **Abstract**

​​Biologics comprise a $511B market of advanced therapeutics that are used to treat cancer, autoimmune diseases, infectious diseases and beyond. Two thirds of biologics are decorated with sugar molecules attached to the therapeutics, including all antibody therapeutics, called monoclonal antibodies (mAbs). These sugar molecules are known as N-glycans and are vitally important for therapeutic safety and efficacy. To date, the N-glycans are poorly controlled and, as such, display highly heterogeneous patterns on a therapeutic. This complicates large-scale production and regulatory approval of biologics, and significantly limits the possibility of using N-glycans in therapeutic design. GlycoBoost revolutionises mAb design by delivering consistent N-glycans, precisely profiled with advanced analytical techniques. This innovation unlocks the full potential of N-glycans to elevate the effectiveness of mAbs.Kyron.bio’s breakthrough technology uses cell engineering to produce therapeutic proteins with uniform and precision-controlled N-glycan patterns. This technology is being used to produce glycoengineered mAbs that are safer and more effective for patients, starting with mAbs used to treat autoimmune diseases where patient resistance to current treatments remains high.Through a well-established collaboration between kyron.bio and Genos, one of the world leaders in glycoanalytics on whose SYSCID project this proposal is built, GlycoBoost aims to advance the project to commercialisation through the development of advanced glycoanalytical techniques, preclinical evaluation, pre-industrialisation, bespoke customer PoC’s, partnership-building, and fundraising. GlycoBoost will place Europe at the heart of the glycobiology revolution, leading to the development of safer and more ef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'BALTIC - TO - BALKAN NETWORK FOR LOGISTICS COMPETENCE' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Based on successful FP5&6 experiences of POLLOCO and CENTRAL LOCO projects, the revised and expanded concept of the B2B LOCO project is that local market-oriented research units - collaborating in an international network aimed at experience exchange - can substantially increase the participation of SMEs in the FP projects by demonstrating and actively promoting the most business practice-oriented results of past and current RTD projects of the FP among the enterprises. The dramatically increased project area covers now 15 countries, including Old and New Member States and 2 Candidate Countries, covering most of the East of the continent and beyond, form Estonia to Israel. B2B LOCO will target Regional Clusters gathering different types of SMEs: transport and logistics companies, manufacturing and retail companies, hi-tech companies and green technologies companies that are of a particular focus of this call. Companies from these three groups are often “FP-ready” yet they are not realising their potential because the FP is best communicated to the research community. Therefore B2B LOCO consortium groups research organisations with considerable experience in FPs and a track record in talking directly to SMEs, using their own language and knowing what drives them in everyday operations. B2B LOCO will provide SME community with two international conferences, two practical workshops and three brokerage events, supplemented with permanent communication mechanisms (www, newsletters, alumni networks). As a result of B2B LOCO activities, SMEs will benefit from advanced solutions developed by FP consortia, experiences of successful SME- RTD - Academia co-operation cases which are laudable and should be copied. In addition to this, project will support processes of forming partne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Women Building Brazil: a history of architecture from the perspective of self-building sites.' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Women Building Brazil (WBB) seeks to underscore women’s contributions to architecture and construction in Brazil, particularly in contexts of self-building. Its main objective is to address the neglect of both women and informal building practices in architectural and construction history, especially in the global South. The project will tackle that double historical gap by gathering personal stories and documentation on women builders. Its premise is that women’s involvement in self-construction was actually quite common in vernacular architecture but has been affected by the introduction of new building technologies and materials. Expanding our disciplinary scope to include vernacular contexts, WBB employs a novel method combining oral history with disruptive archival research methods and community-based participatory practices, guided by feminist and decolonial principles. This approach will be applied in three territories in Brazil where self-building remains a prevalent custom: quilombos (afro-Brazilian maroon communities), indigenous territories and favelas (urban informal settlements). These distinct settings offer new insights to help recover, analyse, and acknowledge women’s construction know-how. The outcomes of WBB include an oral history archive and a public video collection. The participatory process will also generate a memory artefact, co-created with interviewed women with the purpose of recognizing their expertise and strengthening their building autonomy. In summary, WBB offers a new methodological approach to a growing field of construction history and a gendered analysis that contributes to the broader discipline of architectural history. It maintains a commitment to open science through its research methodology and participatory practices, ensuing c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Towards harmonised test methods for nanomaterials' (NanoHarmony), addressing dissemination and exploitation.

assistant: **Impact**

Ensuring the health and safety of both population and the wider environment has been entrusted to specialist EU and international organisations such as the OECD, who are tasked with setting up Test Guidelines (TGs) and Guidance Documents (GDs) by which a substance can be assessed. Engineered nanomaterials (ENM) pose a particular problem due to difficulties in analysis and data interpretation. Adopted TGs are not always suitable for nanoforms, but these are needed to ensure that standards are met for assessing and approving ENMs e.g. in European regulation such as REACH.NanoHarmony supports the development of a set of scientifically reliable test methods and good practice documents, based on the translation of existing scientific knowledge and data into a form that has regulatory relevance. NanoHarmony focusses on OECD TGs and GDs. 8 nanomaterial test endpoints have been prioritised with the agreement of the OECD WPMN and WNT, ECHA and the Malta Initiative, forming the core of the NanoHarmony CSA project.NanoHarmony will coordinate the collection and use of available data and information to support the finalisation of the test method development and to organise a sustainable network for the needed exchange, also for future regulatory development needs. NanoHarmony will therefore analyse the processes in test method developments to set up a framework structure for seamless and smooth cooperation between all stakeholders for timely developments of test methods ready for regulation. For both, finalisation of test methods and framework development, interviews, open workshops and stakeholder meetings are seen as a core tool in NanoHarmony to enable active participation and contributions. By identifying gaps and obstacles, and developing an adequate framework for possible impl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Understanding evolutionary abiotic stress-network plasticity as foundation for new biotechnological strategies' (StressNetAdapt) under Horizon 2020.

assistant: **Objectives**

Abiotic stresses, such as drought or salt stress, affect plant growth and threaten the capacity to feed a growing world population. Understanding and altering how plants deal with stress will be critical for society’s adaptation to a changed climate. I propose a novel systems-biology based approach to identify biotechnological targets based on comparison of interaction and signalling networks of evolutionary related species that show differential abiotic stress tolerance. Similar to most crops, Arabidopsis thaliana is an abiotic-stress sensitive glycophyte whereas several close relatives are stress tolerant. This constitutes an opportunity to understand how plant stress-signalling networks are modified by evolutionary processes to adapt to novel environmental conditions.Biological processes are mediated by physically and functionally interacting proteins. Especially stress response networks are rewired when plants adapt to new environmental conditions. I aim to experimentally map the abiotic stress networks of four closely related brassicaceae: A. thaliana, A. lyrata, A. halleri and E. salsugineum. Novel conceptual advances in interactome mapping and a state-of-the art interactome mapping pipeline will be exploited to ensure direct alignability of the resulting reference networks. In addition the dynamic signalling events under drought stress will be analysed. Using a combination of network alignment, graph theoretical and statistical analyses, data integration, and literature-informed criteria a ranked candidate list of stress response regulators will be assembled. These will be genetically and biotechnologically validated. First level candidates will be tested in Arabidopsis thaliana and evaluated with respect to stress tolerance and overall biomass production. The mo