RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'FOODSAFETY4EU - MULTI-STAKEHOLDER PLATFORM FOR FOOD SAFETY IN EUROPE'.

assistant: **Objectives**

FOODSAFETY4EU is a Project focused to design, develop and release a multi-stakeholder platform for the future European Food Safety System (FSS), by structuring a participatory process, which sustains a responsive and adaptive community of FSS actors. The platform will enable the FSS actors to access efficiently resources and data, synchronize food safety research strategies, share and exchange scientific knowledge and contributions for the future EU FSS. It will boost interactive cooperation within the system and with the civil society for enhancing public confidence through dedicated tools. A European Food Safety Forum will be set up to officially consolidate the participatory process and guarantee the long term science-policy-society interface. New digital tools, co-designed strategies and communication models will support Food Safety Authorities (FSAs), EU Agencies, policy makers, scientists and civil society in a coordinate approach, thus contributing to strengthen the EU approach to risk assessment & communication. The multi-actor consortium is pooled by a core group of 23 partners from 12 countries: scientific experts in food safety will work closely with key actors with complementary knowledge in:a) developing and structuring of participatory processes; b) stakeholders engagement, communication and networking; c) e-platforms, smart tools, data management; d) Food Safety policies implementation; e) representing the voices from food and feed industry, consumers and the civil society. A network of other 44 Food Safety actors – engaged as “Supporting partners” – are committed to populate the platform and interact by expressing opinions, sharing information, data and reports; providing strategy advice and assuring a multiplier impact of project results.


**Keywords:*
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Outcomes and Causal Inference in International Comparative Assessments'.

assistant: **Innovation**

The ETN OCCAM will investigate how educational policies influence educational outcomes worldwide. One of the mostsalient findings in the field of education is that there are huge national differences in student achievement in internationalcomparative studies. The shockingly large gap between the highest performing countries (most of which are in East Asia)and many European countries corresponds to a difference in attainment of two years of schooling. Although this finding hasbeen replicated in several studies, at present, the reasons for and consequences of such differences are not wellunderstood.Variations in many features of educational policies can only be observed across countries on the system level (e.g., theexistence of central exams). Since the start of the new millennium, a new generation of international comparative studieshas been launched: studies like PISA and TIMSS are repeated every few years and thus have a longitudinal component atthe system level. Unlike cross-sectional designs, these trend designs allow the causal effects of changes in educationalpolicies at the system level to be estimated. Applying this approach, alongside other approaches to causal inference, to theaccumulated data from the comparative studies has a huge potential to provide insights into the determinants of educationaloutcomes worldwide.The ETN will provide an ideal environment for training ESRs to become leading experts in educational policy evaluation,international student assessments, and educational and policy consulting. They will receive interdisciplinary and -intersectoral training, and their individual research projects promise groundbreaking new knowledge on how to design fairand efficient educational systems. For this purpose, OCCAM will integrate the complementary exper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'An integrated concept of tumor metastasis: implications for therapy'.

assistant: **Objectives**

From many perspectives our concept of the process of metastasis is inadequate and needs to be revised. In particular, the potential impact of recent ideas about the cellular basis of tumor growth (cancer stem cells) and the establishment by remote tumors of special permissive microenvironments in target organs prior to metastasis (metastatic niches) remains to be explored. In the TuMIC project we will use novel experimental approaches to integrate these newly emerging principles and ideas with the different hypotheses that have until now tried to explain the process of metastasis. Specifically we aim to understand how cancer stem cells behave in and contribute to metastasis, and how networks and pathways that are known to regulate metastasis affect their properties. Further objects are to determine how a permissive microenvironment for metastasis formation is established in given organs, how this contributes to determining patterns of metatasis, and how these microenvironments interact with cancer stem cells. These studies will facilitate the development of an improved and more accurate concept about the process of metastasis. In turn, this will have fundamental ramifications for the way in which novel anti-cancer therapies are designed, and most importantly should provide important new insights into how cancer and in particular metastatic disease can be successfully treated. With this in mind we will also perform preclinical studies that build on TuMIC findings with the aim of developing novel anti-cancer therapies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'iPS-derived MIcroglia and Neuroinflammation in Dementia'.

assistant: **Concept**

Alzheimer’s disease (AD) is an irreversible neurodegenerative condition affecting 50 million people worldwide. To date, no disease modifying therapy for AD is available. Neuroinflammation is emerging as an important component of the disease. A recent GWAS analysis identified a rare protective coding mutation (P522A) in the PLCG2 (Phospholipase C Gamma 2) gene that is associated with AD. Interestingly, the gene encodes a transmembrane signaling enzyme that is highly enriched in microglia. The major aim of the proposal revolves around the functional characterization of the P522A mutation in microglia. To that aim, using an array of biochemical, imaging, functional, and transcriptomic assays, we will investigate human microglia generated from control- and AD patient-derived induced pluripotent stem cells (iPSCs). iPSCs will be gene-edited to generate P522A mutated isogenic cell lines. The proposal aims at identifying novel therapeutic targets and, in line with the objectives of the H2020 Framework Programme, explores new grounds in the molecular underpinnings of AD. The use of cutting-edge and innovative approaches (CRISPR/Cas9 gene editing, iPSC reprogramming, RNA-Seq analysis, high-throughput screening, and subcellular calcium imaging) provides a novel experimental model that is closer to the pathological processes of the AD brain and bypasses the limitations and shortcomings of preclinical AD animal models.


**Keywords:** iPSC, Alzheimer's disease, gene editing, CRISPR, Cas9, RNA-Seq, mitochondria, endoplasmic reticulum, IP3, calcium signaling, bioenergetics, PLCG2, inflammation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'MODULAR INNODRIVE Powered Reel Drive in maritime environment' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Scope of the present proposal is the technical and economic feasibility evaluation of the industrial production and distribution into the EU market of a Modular Powered Reel Drive (PRD) for maritime operations of cable laying and retrieval. The proposed solution, compared to existing products, enables to operate with a significantly wider range of reels, both in terms of reel’s diameter and weight. The result is an innovation that increases safety, flexibility, efficiency and efficacy of maritime cable laying operations.The innovation applies to the maritime cable laying sector, since technology and the market expressed the need for underwater physical interconnections for energy and power networks in sea environments. This requirement is considered to be one of the greatest challenges for a reliable and effective use of world resources.The solution has several advantages compared to currently available PRD because the MODULAR INNODRIVE provides:•Increased efficiency-flexibility•Time and costs reduction•Safer operationsINNOVO Ltd. intends to implement a feasibility study in Phase 1 aimed to achieve the following goals:•Develop the MODULAR INNODRIVE through additional technical adjustments of INNOVO’s 600 mT PRD (the highest product capacity available into the market) to fulfil the modular requirements. This will further position the company at the forefront of maritime cable laying technology. Intellectual Property Rights (IPR) and business strategies for production are additional issues that need to be tackled. INNOVO has the opportunity to develop the proposed solution with its well established industrial partner, CONCRANE S.r.l., an offshore crane manufacturer since more than 60 years, whose headquarters and manufacturing facilities are located in Trieste, Italy.•Dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Simulation of Dielectric Spectra', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Modern spectroscopic techniques allow to measure the frequency dependent dielectric permittivity of complex liquids over about 18 decades, accessing relaxation times ranging from several hours down to the picosecond scale. The central problem in interpreting dielectric spectra is to relate the spectral features to the underlying dynamics of the molecular or atomic components of the fluids. Molecular dynamics simulations could provide in this sense invaluable help. However, a large number of important relaxation processes, responsible for spectral peaks, originate from rare events, the presence of which can severely limit the potential of this simulation technique. Up until now, only standard molecular dynamics simulations have been employed to investigate dielectric spectra, and the capabilities of enhanced sampling techniques such as metadynamics or parallel tempering have been largely neglected in this field. In addition, liquids other than water have received relatively little attention in the framework of computational dielectric spectroscopy, even though plenty of  important problems are still waiting for an answer. I will fill this gap by putting forward an approach which combines the knowledge of the free energy landscape provided by enhanced sampling techniques with the information accessible by molecular dynamics simulations. I will use this novel approach to tackle two compelling problems (the origin of the excess wing in liquid glycerol spectra and the ion pairing properties in room temperature ionic liquids) in the fundamental understanding of two materials which are crucial for the modern economy. The SIDIS approach is expected to have an important impact on the field of computational dielectric spectroscopy, as it will lay the foundations of a new data ana
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Program Exchange for Chiral Symmetry' (EXQIRAL), addressing dissemination and exploitation.

assistant: **Impact**

EXQIRAL is a proposed 4-year exchange program between the Max Planck Society, ICFO (Barcelona), the Weizmann Institute of Science (Israel), University of Pisa and MIT (USA). The researchers exchange will be based on pre-existing scientific program between these partners and will provide the researchers with a collaborative environment to address fundamental questions in the field of topology, chirality, twistronics or quantum chemistry, amongst others. Many fundamental breakthroughs in science will result from the development of new techniques in this synergetic program: EXQIRAL will develop specialized tools for exploring the chiral nature of matter as well as fabricating novel tuneable devices that take advantage of the unique properties of chiral matter. EXQIRAL will bring tremendous added value not only to the research programs that it will catalyze and incentivize but also in the training and mentoring of young scientists to carry out research that is bold, of high risk, and that will lead to the greatest impact on the scientific world and beyond. EXQIRAL will create a range of structural components that are designed to promote risk taking both in scientific exploration as well as in the translation of research findings to impact on society. A major mission of EXQIRAL will be to foster the careers of the most brilliant young scientists at the participating institutes and, especially, to create structuEXQIRAL is a four-year staff exchange multidisciplinary program between 4 academic partners of four European countries: ICFO (Spain), Weizmann (Israel), Uni Pisa (Italy), MPG (Dresden), and one third-country (MIT, USA). This collaboration is based on an existing program and established collaboration amongst these institutions. The combination of expertise from the five
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A provincial capital polis at the end of the Roman era. Periphery or a center of power?' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

This project proposes a comprehensive multi-disciplinary study of a Roman provincial capital in the period of the transition from Late Antiquity to the Middle Ages. It is based on a case study of three of the most richly-documented provincial capitals, Antinoopolis, Ravenna and Petra, but encompasses similar provincial centers across the Mediterranean world and beyond in order to build a model of the administration of justice and enforcement of law in Late Antiquity. This topic is closely linked to communication between the provincial capitals and the imperial court in Constantinople and will shed light on the dynamics of the transmission of laws. It also contributes to the understanding of the shared legal culture of Late Antique provincial capitals, a major factor in the successful administration of provinces.The model of provincial government will be based on the formal juridical, legislative and executive powers of the governor, his official staff, and the city council, and an elucidation of their capacity to carry out their functions successfully in the context of new social and cultural realities. Furthermore, it will provide insight into the dynamics of power between the central administrative apparatus, the city apparatus, and prominent landowners, religious institutions and clergy, and the villages. The study focuses on the period between the 5th and 7th c., when it became increasingly challenging for governors and other officials to exercise the powers conferred upon them by the emperors. This was a pervasive phenomenon across the entire Empire, resulting from the emergence of a new landowning class who possessed economic and military capabilities that far exceeded those of their predecessors. Moreover, there were persistent incursions from nomadic groups in t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A principal-based EU challenge to East Central European judicial interpretation of constitutional identity'.

assistant: **Objectives**

The overall aim of the research is to provide a new theoretical basis for a principle-based EU challenge to the domestic judicial interpretations of constitutional identity. It is of utmost importance, because East Central European courts apply an ethno-cultural understanding of identity, thereby putting European integration in peril.Although the EU is clearly committed to shared values and principles, Article 4(2) of the Treaty on European Union  emphasizes that “the Union shall respect the national identities of the Member States”. Due to the recent migration flow, the Member States are currently attempting to define themselves and offer a legal definition of identity. However, East Central European Member States, by labeling national identity as constitutional identity, apply Article 4(2) as a means of derogating from some of their obligations under EU law.Despite the vast literature available on national identity and its role in EU law, there has been little attention paid to the recently emerging trend of judicial reinvention of identity in East Central Europe. This is what this research offers. It focuses on the Visegrád Group (V4), which consists of the Czech Republic, Hungary, Poland, and Slovakia. The V4 countries are united in their views on rejecting migrant relocation quotas in the EU and define their exclusionary constitutional identities accordingly. The main subject of the research is the relevant case law of the constitutional courts, since the V4 courts have an authoritative role in enforcing nation-state policies based upon ethno-cultural considerations.The project provides a new theoretical basis and a comparative-analytical description of the judicial interpretations of constitutional identity in the V4 countries based on which we can better understa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Energy signaling in the stress response' under Seventh Framework.

assistant: **Concept**

Plants are constantly confronted by multiple types of nutritional, abiotic and biotic stress. Often associated with stress is a reduction in photosynthesis and/or respiration, which in turn results in energy deprivation and ultimately in growth arrest. Despite their distinct origin and mode of perception, different stresses trigger similar downstream responses that include largely overlapping patterns of gene expression. Our work has shown that this general stress transcriptome is partly regulated by the evolutionarily conserved energy sensor protein kinases, SNF1 (sucrose non-fermenting1) in yeast, AMPK (AMP-activated protein kinase) in mammals and SnRK1 (Snf1-related kinase1) in plants. Upon sensing the energy deficit associated with stress, SnRK1 triggers extensive transcriptional changes that contribute to restoring metabolic and energy homeostasis, promoting cell survival and allowing the elaboration of longer-term responses for adaptation, growth and development. Despite the importance of the uncovered energy signaling pathway, virtually nothing is known regarding its mode of operation. Using a combination of cell-based assays, functional genomics, bioinformatics, mutant screens and genetics, this proposal seeks to gain insight on the regulatory mechanisms that govern SnRK1 action and to further dissect this signaling pathway through the identification of novel components. Elucidation of these mechanisms will contribute to understanding how stress resistance is established and how plant growth and development are finely orchestrated by the environment.