RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Changing Water Cultures' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The changing climate is disrupting fresh water infrastructures. Dominant technocratic systems of knowledge and practice supporting water infrastructures in Europe are being undermined by rapid changes, which introduce new uncertainties and contest old securities. We need novel ways of mobilising knowledge for water infrastructures that readmits communities’ diverse cultural interactions with water to promote adaptive decision-making.The CANALS project begins from three claims; (i) that current understandings of water, climate and infrastructures struggle to address emerging uncertainties due to climate change; (ii) that a proper regard for water cultures is needed to overcome these obstacles; particularly by (iii) extending the ‘peer communities’ of diverse knowledge-holders. CANALS’ water culture perspective understands cultures as both practices and systems of symbols and meanings. It recognises the hybrid character of water, which exists independently of humans and at the same time is culturally enacted through human practices. It also sees infrastructures as social practices connecting people and objects in the world in socio-material relations. A water-cultural perspective thus better captures the complex processes around water infrastructures in the context of challenges posed by climate change.Adopting an innovative water culture perspective, CANALS will first make visible the spectrum of knowledges and practices used by different social groups for maintaining infrastructures. Going further, the project will develop transdisciplinary ways of convening an ‘extended peer community’ of water stakeholders, to together appraise the quality of their water knowledges for policy-making.CANALS creates the conditions for me to advance the scholarship on water infrastructur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Servicing the European Biomedical Research Community:  Archiving and Dissemination of Mouse Models of Human Disease' under Seventh Framework.

assistant: **Concept**

The mouse shows great similarities in development, physiology and biochemistry to humans, which makes it a key model for research into human disease. The major challenges for mouse functional genomics in the 21st century are to:1) Develop a series of mutant alleles for every gene in the mouse genome2) Determine the phenotypic consequences of each mutation3) Identify mouse models for the complete disease spectrum in humansTo exploit this emerging resource, mouse models must be preserved and made available to the European biomedical research community. Building on EMMA's previous achievements as the primary mouse repository in Europe, EMMAservice aims to meet the future challenges presented by archiving and disseminating mouse models in the ERA as follows:- Archiving of 1224 new mouse mutant lines in support of individual depositors and also European mouse genetics programmes- Support of eligible customers with free of charge Transnational Access for up to 20% of requested mouse resources.- Technology development will underpin the archiving and distribution efforts by advancing current sperm freezing technology- Training courses will promote the shipment of frozen germplasm rather than live mice- EMMA informatics will support user services by setting new standards for user friendly accession of EMMA services, extensive data curation and cross referencing with other mouse database resources- Outreach efforts to attract users will be widened and addressed at the translational research communityEMMAservice will contribute significantly to the development of a world leading repository and European capacity in mouse disease model archiving and distribution, supporting the needs of the wider European biomedical research community. The emerging mouse mutant and associated data r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advanced Material Combinations for use in water pumps' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The objective of the project will be to identify, develop and demonstrate new material configurations which will eventually lead to the improvement of the reliability and durability of water and water based fluid pumps. The aim of the project will be to develop and assess novel material configurations with the necessary mechanical and physical properties to improve the wear characteristics of water and water based fluid pumps. This will involve investigating, exploiting and demonstrating recent advances achieved in material technology. In undertaking the project the emphasis of the research will be on developing a material with sufficient hardness and low lubricity requirement to significantly reduce the amount of adhesive and abrasive wear of moving surfaces. This will eventually help to achieve a pump with higher reliability and lower maintenance requirements. The materials technology will be specifically applied to the components used in positive displacement pumps including centrifugal pumps, propeller pumps and gear pumps. In achieving this, the actual design configuration of these pumps will also be addressed and will undergo experimental development with respect to the materials characteristics employed. As part of the project, work will be undertaken to investigate the use of ceramics, cermets, and other non metalics as low wearing and non corroding component materials. This will include the research and development of materials previously unused for this particular application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Arctic Symposium on Mechanisms of Memory and Memory Disorders'.

assistant: **Innovation**

The scientific objective of the meeting is to allow neuroscientists from different disciplines in European top research to present their recent results and speculate on the mechanisms of memory and memory disorders. In addition, there will be invited speakers, leading specialists from each topic coming from all over the world. The concept is to spend one arctic weekend with other neuroscientists from different disciliplines who will focus only on basic mechanisms of memory and memory disorders to germinate new ideas and support the development of collaboration between European research groups. Contribution and participation of both young and female scientists will be emphasized.The meeting will consist of five different sessions named: 1) Declarative memory, anatomy of networks, behavioral animal and human studies, 2) Amygdalo-hippocampal interplay in physiological processing and epilepsy, 3) Long-term potentiation as a model of learning and memory, 4) Physiological and pathological plasticity and 5) Hippocampal networks in learning and memory.The duration of each session will be three hours and consist of five presentations. The sessions will be divided so, that half of the presentation is given by a young scientist (post doc or advanced graduate student) and commented on by the leading senior scientist. Adequate time for discussion with will be included after each presentation. Between the morning and afternoon sessions there will be a three-hour break to allow small group tutorials in special interest groups, and for graduate students to present their poster presentations. The way this congress is organised will encourage communication between top senior scientists and advanced young scientists, providing sufficient time for discussions and planning of future collabo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Effect of indigestible fraction from different European Diets on the regulation of intestinal microflora; relationship with colorectal cancer protection' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Statistic can not always explain some differences in epidemiological data. For example, in the south of Europe the smoker rate is higher than in the north and the cancer levels are lower, contradicting the statistics expectative. Ambient conditions and the way of life strongly influence these results, and among them, diet is one of the most important factor in cancer development, specially for cancers that affect organs in the gastrointestinal tract. Among this group of cancers, colorectal cancer is the mos t frecuent cause of cancer death in developed countries. Recently a new concept, as alternative of dietary fibre, has been established in our laboratory: Indigestible Fraction (IF). It comprises most components of vegetable foods that escapes digestion and absorption in the small intestine, reaching the colon where it is susceptible to bacterial fermentation. The target of this project is to determinate the IF from the most representative European diets (Mediterranean, Centre European/ Anglo-Saxon, North Eu ropean and East European). After quantification, composition will be determined and two characteristics will be studied, intestinal microflora control and the possible role in colorectal cancer protection. For this purpose established, adapted and new meth ods will be used. Due to the high impact of colorectal cancer in the United States of America and the increasing influence of their gastronomy in Europe, North American diet will also be studied and compared with the European. Result will be compared with epidemiological data related to colorectal cancer and intestinal infections from the correspondent regions. We try to find a correlation between quantity and quality of IF ingested and disease risk.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Evolution of Regulatory Landscapes in Chordates'.

assistant: **Innovation**

Evolution of animal forms largely depends on changes in developmental gene expression patterns. These genes are controlled by a large number of cis-regulatory elements (CREs) distributed in extended genomic regions organized in 3D chromatin structures known as regulatory landscapes (RLs). However, it is currently unknown how these RLs originate and evolve and how changes in RL architecture and associated CREs have impacted the evolution of gene expression and animal body plans. The aim of this proposal is to understand the evolution and origin of vertebrate regulatory genomic architecture. For that, I will generate an extensive epigenetic and topological profiling of the European amphioxus genome, a slow-evolving basal invertebrate chordate. I will study RLs 3D chromatin architecture, enhancers, promoters, open chromatin and nucleosome positioning through amphioxus embryogenesis using 4C-seq, ChIP-seq, ATAC-seq and RNA-seq and compare these datasets with equivalent results from vertebrates. This will allow me to identify the core RLs organizations that we and other vertebrates share and that underlie the novel and conserved features that characterize our body plan. These results will make ground breaking advances in our understanding of how the regulatory architecture of our genome was assembled during evolution, providing new insights on how RLs organization has impacted gene expression and, ultimately, evolution of animal morphology. By the execution of EVOREL innovative techniques and multi-disciplinary approaches to unveil the deep roots of the human regulatory architecture, I will start a promising research program that will secure my future career as an independent group leader.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European Nanomedicine Characterization Laboratory' under Horizon 2020.

assistant: **Concept**

In order to accelerate the development of the nanomedicine business in Europe, EU-NCL interconnects 8 European and 1 American key reference facilities with a proven expertise in physical, chemical, in vitro and in vivo biological characterisation of nanoparticles for medical applications. The objective is to reach a level of international excellence in nanomedicine characterization for all medical indication, and make it accessible to all organisations developing candidate nanomedicines prior to their submission to the regulatory agencies in order to get the approval for clinical trials and later the marketing authorization. EU-NCL is partnered with the sole international reference facility namely the Nanotechnology Characterisation Lab of the USA to get a faster international harmonization of analytical protocols. EU-NCL is closely connected to national medicine agencies and to the European Medicine Agency in order to permanently adapt its analytical services to the need and requests of the regulators. EU-NCL is designed, organized and operated according to the highest EU regulatory and quality standards in order to provide a full analytical cascade of 42 assays. Within EU-NCL, 6 analytical facilities will offer a Trans National Access to their existing analytical services but they will also develop new or improved analytical assays under the Joint Research Activities in order to keep EU-NCL at the cutting edge of the nanomedicine characterisation. A complementary set of networking activities will make EU-NCL able to deliver to the European academic or industrial scientists the best analytical services they dramatically require for accelerating the industrial development of their candidate nanomedicines. An exploitation and business plan will be proposed at the end of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Hyaluronic-Cisplatin Film for Implant in Malignant Mesothelioma Recurrence' (Hyalcis), addressing dissemination and exploitation.

assistant: **Impact**

Hyalcis is a novel medicinal product, based on an innovative biodegradable film technology, for the prevention of the recurrence after surgery of malignant pleural mesothelioma. The proposing company, PlumeStars s.r.l., has successfully applied to the European Medical Agency, obtaining in 2016 the orphan designation for Hyalcis. This entitles PlumeStars as unique provider of the product, i.e, a polymeric film to treat pleura mesothelioma, for which there are no satisfactory curative methods. To capture this unique business opportunity, the Phase 1 project will develop a detailed Business Plan achievable within 6 months, including technical feasibility assessment based on qualified feedback and requirements from users, detailed market analysis, competitors analysis, industrialization planning, key partnerships preparation, knowledge protection and financial planning. Mesothelioma is a very aggressive form of cancer linked to asbestos use in construction and industry. It is difficult to diagnose, highly resistant to treatment and full recovery is extremely rare. Over 43,000 people die every year worldwide for the disease and that 10,000 new cases of mesothelioma combined in Europe, North America, Japan and Australia occur each year. The solution developed by PlumeStars is a hydrophilic, thin and flexible film, sufficiently resistant to be applied intrapleural or in other districts, adhering to the mesothelial or epithelial surfaces. The cisplatin release from the film is prolonged providing high local concentrations of anticancer drug, precisely in situ where the residual tumor could develop. This introduces significant benefits in terms of effectiveness, limiting tumor recurrence, low toxicity and increased safety and efficiency. This benefits have been confirmed in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Implementation of contrast-ultrasound dispersion imaging for better prostate cancer care'.

assistant: **Innovation**

Prostate cancer (PCa) causes 1/5 of new cancer cases and 1/10 of cancer deaths in western males. Timely diagnosis is crucial to enable effective treatment, but this is hampered by the inadequacy and cost of the available diagnostics based on multiple systematic biopsies, which cause discomfort and health risks because of their invasiveness. Moreover, they fail to provide accurate cancer localization, resulting in either over- or under-treatment. A new diagnostic method is thus needed that is accurate and cost-effective. Our ambition is to provide patients with accurate diagnosis of PCa by ultrasound imaging. Because ultrasound equipment is affordable and widely available, our method will save lives and cost by enabling noninvasive, timely diagnosis. Over the past years, through a synergic effort of technical and clinical research, we have developed contrast-ultrasound dispersion imaging (CUDI), a revolutionary option to determine cancer location and aggressiveness by detection and characterization of cancer angiogenesis. Our results in 150 patients confirm the accuracy and clinical value of the method.With this project, we will take CUDI to the next level, establishing the basis for its clinical and commercial translation. To this end, we will realize a commercially-viable software implementation, accounting for user experience, clinical workflow, and regulatory compliance. This project will build on a strong network of international collaborations with key opinion leaders in PCa diagnostics and treatment. We will also account for patient experience via the Dutch Prostate Cancer Association. The establishment of a dedicated start-up driving the valorization activities will provide an additional boost towards the clinical implementation of CUDI.Our experienced project te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a sustainable strategy for the management of root-knot nematodes in vegetable crops in southern europe - an alternative to the use of methylbromide' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

This project will lead to the development of a sustainable strategy for the managementof root-knot~ nematodes in vegetable crops in southern Europe and will evaluate an alternative to the use of the soil fumigant, methyl bromide. The project provides a model for the practical application of a soil~ applied biological control agent and the development of a rational policy for such releases. The specific research objectives are to: 1. Evaluate the efficacy of the biomanagement strategy in commercial production systems and compare the control of root-knot populations and crop yields with conventional control methods using methyl bromide and with integrated procedures that combine the use of the biological control agent, granular nematicides and crop rotation. 2. Develop methods to monitor the fungus after its release using immunological and molecular techniques. 3. Measure the impact of the fungus on soil microbial diversity and non-target organisms. The programme is innovative and will:  - provide new microbiological techniques for studies of fungi in the rhizosphere.  - develop a novel environmentally benign strategy for nematode control.  - provide new information on the ecology and spread of biological agents after their release in the field.  - for the first time, establish a comprehensive dataset to assess the practicality and risk assessment of a biomanagement strategy for nematode pests. The project will lead to the development of non or low chemical methods of nematode management which are more environmentally friendly than existing methods and will lead to a reduction in inputs. Thus it is in line with Article 3 of CAP Directive 91 414 and COMDOC (93) 202 aimed at alternatives to the use of methyl bromide. The environmental impact of the new strategies being deve