RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enlarging the ERA-MORE network: the Mobility Centre Luxembourg' in the context of a Seventh Framework call.

assistant: **Objectives**

The Mobility Centre Luxembourg aims at being a new link in the ERA-MORE network, setting up procedures, services and networking in order to help incoming researchers organise their research stay in Luxembourg. The project amounts to structuring comprehensive information on all aspects involved in a research stay and making it available through an Internet Portal linked to the European Researchers' Mobility Portal, a help desk and communication tools.  The Minister for Culture, higher education and Research has entrusted the University of Luxembourg with this task. With the help of a steering group involving the main public research institutions of Luxembourg, it will coordinate all actions towards welcoming researchers on a national level and will also help coordinate actions on a European level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Shearwaters' Olfaction: a comparative study of sensory ecology in the Mediterranean Sea and Atlantic Ocean' in the context of a Seventh Framework call.

assistant: **Objectives**

Petrels (order Procellariiformes) are seabirds found in worldwide oceans with a high diversity of species and characterized by pelagic and wide-ranging lifestyle. Some recent study showed that their well-developed sense of smell plays a key role in locating patchily distributed food resources in the ocean, in nest finding at night, and for mate recognition. However, different species of petrels tested responded differently to olfactory stimuli according to their ecology. This suggests that odours responsiveness may be linked to specific adaptations, but sensory ecology of petrels is understudied and comparative studies are virtually missing. We hypothesize that different environmental constraints in close seas and open oceans, may have led to rely differently on olfactory cues. Here, we propose a comprehensive comparative study aimed to investigate how olfaction contributes to behaviours such as homing, foraging, individual and predators’ odour recognition and migration routes, using Cory’s shearwaters as model species. We will try to identify the evolutionary adaptations to different environments, comparing sensory ecology of different populations of this species breeding in the Mediterranean Sea and in the Atlantic Ocean. We will also integrate ecological and behavioural data with chemical and phylogenetical analyses. The results of this study will be fundamental for the knowledge and conservation of this species. The Host institution is so far the only one in Europe dealing with olfaction and sensory ecology of seabirds. The proposed research, characterized by the promotion of international collaboration among different European Members, will bring the European Research Area in the forefront of olfactory and sensory ecology research, and to be a reference for the wor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Inventory and analysis of biotech programmes and related activities in all countries participating in the biotechnology programme 1994-1998 -part 4' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

This proposal is linked with three related projects (Parts 1, 2, and 3 of the same title) which, taken as a whole, have the main objective to produce an exhaustive inventory, analysis and overview of biotechnology research, technology and development (RTD) in EU and EFTA/EEA countries directly stimulated by specific public programmes. The project covers: (a) each Member State which participated in the Biotechnology Programme 1994-1998; (b) the most important topics in biotech research, including the priority topics of the Biotechnology Programme 1994-1998 (c) making an overview of a range of factors connected to the conditions, policies and impacts etc. of these public programmes (d) and producing, on the basis of this overview, analyses, conclusions and recommendations. In deciding on specific topics and factors to be included in (b) and (c), we will be guided by a Steering Group including officials from the EC responsible for this study and a selection of governmental representatives and scientists which function as contact people in the EU and EFTA/EEA Member States for the Biotechnology Programme 1994-1998. We will combine (b) and (c) in a matrix (biotech topics versus factors) for each Member State in (a). After the information and data on programmes concerning R&D and related activities for each country are collected and put in the matrix, an analysis will be made to provide an overview of biotech RTD in countries participating in the Biotechnology Programme, including the extent of co-ordination between European and national biotech programmes and related activities. The purpose of this specific proposal (part 4) will be to produce an analysis, final report and recommendations at the European level, which will be based on the national inventories and reports of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European eXtreme Data and Computing Initiative - 2' (EXDCI-2), addressing dissemination and exploitation.

assistant: **Impact**

The project EXDCI-2 builds upon the success of EXDCI and will continue the coordination of the HPC ecosystem with important enhancements to better address the convergence of big data, cloud and HPC. EXDCI-2 strategic objectives are a) Development and advocacy of a competitive European HPC Exascale Strategy and b) Coordination of the stakeholder community for European HPC at the Exascale.EXDCI-2 mobilizes the European HPC stakeholders through the joint action of PRACE and ETP4HPC. It will promote global community structuring and synchronization in HPC, Big Data, Cloud and embedded computing, for a more competitive related value chain in Europe. It will develop a HPC technology roadmap addressing the convergence with HPDA and the emergence of new HPC uses. It will deliver application and applied mathematics roadmaps that will pave the road towards exascale simulation in academic and industrial domains. It will develop a shared vision for the future of HPC that increases the synergies and prepares for targeted research collaborations. EXDCI-2 will work to increase the impact of the H2020 HPC research projects, by identifying synergies and supporting market acceptance of the results.At the international level, EXDCI-2 will contribute to the international visibility of Europe, develop contacts with the world leading HPC ecosystems and increase European impact on HPC standards.EXDCI-2 will improve the HPC awareness by developing international event such as the European HPC Summit and by targeting specific audience through dedicated media. It will disseminate the achievements of the European HPC ecosystem.


**Keywords:** HPC, Exascale, Coordination HPC Ecosystem, CoE, FETHPC, European HPC Strategy, Roadmaps, HPC Technology, HPC Applications, PRACE, ETP4HPC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Strengthening road transport research cooperation between Europe and emerging international markets'.

assistant: **Innovation**

The SIMBA project intends to increase RTD cooperation between the EU and the emerging markets of China, India, Brazil and South Africa. SIMBA will bring together European Intelligent Transport Systems (ITS), infrastructure and vehicle maker practitioners and technology providers with their counterparts in China, India, Brazil and South Africa in order to establish a cooperation network that will discuss how to increase road safety, mobility and transport efficiency in these countries through the exchange of technological know-how and closer cooperation. The project will map the national and regional RTD activities, policies and future requirements and propose demonstration cases to the regional stakeholders, organise seminars, business meetings, and industry visits in order to keep a close contact between the key players. The main objectives of the project are to: Increase road safety, Improve mobility, Enhance transport efficiency. In order to achieve this, the SIMBA project will: - Prepare, support and facilitate the rapid adoption and transfer of technologies and research results;- Define R&D priorities and future cooperation areas;- Make recommendations for new innovative road research activities to be launched locally and in the EU; - Increase the visibility of the European industry and support the industry to respond to emerging business opportunities; This will be done through three enablers: ITS, automotive technological development and road infrastructure.The main activities of SIMBA will be to organise events in the EU and the emerging market that will serve as a means for fostering closer ties between Europe and the EM in the road transport sector and exchanging knowledge in the fields of ITS, road infrastructure and automotive technological development. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Molecular and cellular mechanisms of phototoxicity. Multidisciplinary strategy for predicting in vitro the phototoxic risk of new drugs to humans'.

assistant: **Concept**

- Identification of the mechanistic routes and the reactive species (radicals, singlet oxygen, etc.) involved in drug photosensitisation and development of specific mechanistic assays.- lmprovement of the sensitivity and prediction accuracy of in vitro phototoxicity models: end-points for the early detection of cell misfunction (inflammatory mediators, heat-shock proteins);.- Assessment of systemic drug phototoxicity- Elucidation of the basic mechanisms of drug photoallergy.- lnvestigation of the mechanisms of drug-photosensitised genotoxicity, mutagenicity and carcinogenesis- Analysis of in vitro results on the basis of human in vivo data (prospective and/or retrospective clinical studies on drug photosensitisation).- Establishment of structure-activity relationships.There is accumulated evidence that the interaction of drugs with sunlight may result in cutaneous phototoxicity. Its prediction has been attempted using both in vivo and in vitro models. Although some advances have been achieved, the results are frequently misleading because they presently provide limited mechanistic information. Phototoxicity starts with sunlight absorption by the drug, which reaches an excited state. This species often deactivates through the formation of free radicals or sing let oxygen, which are able to promote oxidation of biomolecules. Further possibilities are the formation of toxic photoproducts or photobinding to biomolecules. Any of the above routes may trigger adversecutaneous effects. In view of the mechanistic complexity, research is needed to develop reliable models to anticipate the phototoxic risk of new drugs to human health. In order to design such methodologies some aspects demand further attention, e.g. relationship between photochemical mechanisms involved and observe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Lightsheet Brillouin Nanoscopy: mechano-sensitive superresolution imaging for regenerative medicine'.

assistant: **Objectives**

Better microscopes have always triggered scientific discovery. Lightsheet microscopy and nanoscopy are no exception and have initiated knowledge jumps in structural and dynamical imaging. However, they do not inform us on mechanical properties. The domain of mechano-sensitive microscopy is still in its infancy yet has already unveiled a stark dependence of cellular development on local stiffness and viscoelasticity. For instance, coordinated strain on the sub-millimetre scale is a key ingredient to grow induced pluripotent stem stells into a beating adult cardiac muscle; without such an environment, a twitching heap of cardiomyocytes develops instead. What are the processes within cells that cause this forked differentiation? How can we optimise the growth of artificial tissue in regenerative medicine? Given the dynamics and 3D nature of the problem, paired with the requirement of sub-cellular resolution, one must conclude that our current instrumentation is not up to the task. Thus, this project aims to develop a label-free microscopy technique that can image viscoelasticity at unprecedented sub-diffraction resolution inside living, differentiating cardiac tissues at order-of-magnitude faster acquisition speeds than previously possible. This will be made possible by a completely new type of optical element that allows snap-shot hyperspectral imaging at unparalleled speed and sensitivity. Transforming latest innovations within nanoscopy and lightsheet imaging and using Brillouin scattering as a proxy for viscoelastic tissue properties on the microscale, Lightsheet Brillouin Nanoscopy (LiBriNa), will be the fastest, most gentle, and highest resolution mechanosensitive microscope ever built. Besides being an enabler technology for cellular biology and regenerative medicin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The role of mesophilic crenarchaea in soil nitrification' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The aim of the project is to determine the role of a recently discovered, ubiquitous and abundant group of microorganisms, the autotrophic, ammonia oxidising mesophilic crenarchaea, in a major biogeochemical cycling process, soil nitrification. Microcosm systems will be used to determine the changes in diversity and activities of both bacterial and crenarchaeal ammonia oxidiser communities, and nitrification rates, under the influence of major environmental factors, ammonia concentration and oxygen availability. Experiments will be carried out in two contrasting European soils, fertilised and unfertilised grassland soils and wetland soils, subject to different levels of oxygen availability. In addition, the distribution of ammonia oxidation potential and carbon dioxide fixation throughout the crenarchaeal kingdom will be determined. The project will employ advanced molecular techniques and the fellow will therefore receive extensive training in cutting-edge techniques used to determine the links between microbial community structure and ecosystem function. These techniques will involve cultivation-independent in situ methods for determination of changes in community structure, transcriptional activity, stable isotope probing, metagenomics and 454 pyrosequencing. Training will be organised through a personal development plan which will also include formal courses and training programmes in complementary, generic skills operated by the host institution. The fellow will also develop supervisory skills through supervision of Master project students. Training will be supplemented through transnational collaboration and through national and international collaborations in multidisciplinary projects. The project will develop the conceptual, technical and managerial skills of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Soil remediation of per- and polyfluoroalkyl substances (PFAS) to layered double hydroxides (LDHs) – Development, regeneration and mechanisms for injectable soil encapsulating sorbent (LDH-PFAS-SORP)' (PFAS).

assistant: **Concept**

Per- and polyfluorinated substances (PFASs) are a growing global concern due to their persistence, bioaccumulation, and high environmental risk, particularly when they contaminate soil and drinking water sources. Effective remediation techniques are urgently needed. Previous research demonstrated that nano-sized layered double hydroxides (LDHs) show great potential for PFAS sorption and can be used as in-situ, injectable liquids to form permeable active barriers. However, to fully utilize LDHs for remediation, their PFAS sorption capabilities and reaction mechanisms must be better understood. This project aims to explore these mechanisms using advanced analytical chemistry, specifically high-resolution mass spectrometry (HRMS) techniques developed by Dr. Gago-Ferrero’s team at IDAEA-CSIC.The fellowship will provide expertise and training in: 1) chemical analysis, focusing on advanced HRMS-based non-target strategies; 2) the synthesis of advanced physiochemical models; and 3) professional development for academic growth. By combining IDAEA-CSIC’s state-of-the-art analytical chemistry capabilities with the applicant’s expertise in soil remediation, PFAS-SORP aims to develop advanced soil remediation techniques for PFAS. Additionally, real-time material property deterioration will be investigated using EXAFS and XANES analysis at MAXLAB IV. This novel approach to using HRMS to understand molecular mechanisms in environmental engineering will set a new benchmark for future environmental remediation techniques.


**Keywords:** PFAS soil remediation by elucidating and optimizing reaction mechanisms using novel high resolution mass spectometry and big data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Investigating the effects of immunogenic chemoradiation in shaping the immune landscape of esophageal cancers'.

assistant: **Innovation**

Esophageal carcinoma (EC) is among the top 10 deadliest cancers worldwide. The current standardtherapy for ES is neoadjuvant (pre-operative) chemoradiation (NACR) followed by surgery. However,only 30% of patients achieve a complete pathological response (CPR) and long-term survival.Understanding the mechanisms of response to NACR is hence pivotal to better stratify patients andinform the design of more efficacious therapies. Evidence from some tumors suggests that NACR is“immunogenic” and stimulates anti-cancer immune responses, which may contribute to the longtermeffects of successful treatments. Tumor neo-antigens, generated by somatically mutatedcancer genes, have been recently implicated in the activation of the most efficient anti-tumor T cellresponse capable of controlling tumor progression, induced by immune checkpoint blockadeimmunotherapy. This raises the question as to whether clinical responses induced by NACR in afraction of ECs may be linked to the stimulation of clinically relevant T cell responses against tumorneoantigens, implying that activating tumor immunity in the non-responding ones may improveclinical responses. Objective of this proof-of-concept study is hence to address this question throughthe implementation of a high-throughput platform to assess neoantigen-specific T cell responses inECs in the course of NACR.