RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Non-commutative deformations of quantum field theory' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Non-commutative quantum field theories and their associated deformed symmetries provide intriguing examples of models beyond the realm of standard local quantum field theory.  Of particular interest are those theories in which space-time coordinates form a Lie algebra since the same structure is encountered in the quantization of gravitating particles in three dimensions.  Associated to this type of non-commutativity are group-valued plane waves and a curved momentum space.  Relativistic symmetries are deformed in the sense that the action of generators of Lorentz transformations on momentum space is non-linear and non-symmetric on products of plane waves.  The candidate's research to date has mainly revolved around the only known four dimensional example of non-commutative field theory with a momentum group manifold, fields on kappa-Minkowski space, and to explore the consequences that the associated deformed symmetries, the kappa-Poincare' algebra, might have phenomenologically and for black hole quantum radiance.The future research, besides continuing along the agenda dictated by the applicant's current achievements, will explore the neighboring fields of lower dimensional (quantum) gravity, semi-classical gravity and other field theoretic models beyond local QFT.  Building on the recent results on deformed two-point functions, the research will explore the consequences of the new structures for inflationary cosmology and black hole radiance.  Part of the project will focus on the possible applications of the tools gathered over the years of study of field theories with curved momentum space to field theoretic models with similar features like group field theories and theories over fractal space times.  Finally, on the longer term, the research will focus on the stud
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A synthetic biology approach to engineering exhaustion-free T cell therapies. Uncovering and counteracting biomechanical triggers of T cell dysfunction in the tumour microenvironment.' (Tex-Mex) targeting Horizon 2020.

assistant: **Abstract**

Cancer is the second leading cause of death in the European Union, having killed 1.4 million people in 2018 alone. Chimeric antigen receptor (CAR) T cell therapy is a ground-breaking cancer treatment that has demonstrated striking results in fighting blood cancers. However, T cell exhaustion, a process that results in the progressive development of lymphocyte dysfunction due to prolonged antigen stimulation in cancer, chronic inflammation or infection, has been a major obstacle in translating CAR T cell therapy to solid tumours. The solid tumour microenvironment is biomechanically distinct from physiological conditions, being characterized by higher interstitial pressures, higher stiffness and a distinctive vascular architecture. While biochemical triggers for T cell exhaustion have been well characterized, biomechanical influences are understudied. This project seeks to (i) use a microfluidic model to add the biomechanical dimension to our current understanding of the development of T cell exhaustion and (ii) use synthetic biological approaches to engineer “biomechanosensor-actuator devices”. These will be intracellular systems based on synthetic biological circuits that will integrate biochemical and biomechanical cues of T cell exhaustion and trigger genetic pathways to counteract the development of dysfunctional phenotypes. Integrating the biomechanical and biochemical dimensions will yield a more sophisticated cell therapy platform to neutralize T cell exhaustion. Ultimately this would provide a safer, more effective and universal treatment for cancer by preventing T cell exhaustion and immune escape.


**Keywords:** Synthetic Biology, T Cell Exhaustion, Biomechanics, Microfluidics, 3D Scaffolds, Tumour Architecture
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Combating Malnutrition in Africa Through Diversification of the Food System' (HealthyDiets4Africa) under Horizon Europe.

assistant: **Objectives**

Various forms of malnutrition, including hunger, micronutrient deficiencies and non-communicable diseases caused by unbalanced nutrition, threaten food security in Africa. The project HealthyDiest4Africa is based on the central hypothesis that diversification of the  food system helps to combat all forms of malnutrition while minimizing its environmental footprint. To this aim, we will monitor dietary diversity in eight African countries representing different regions, and develop target group-specific metrics to measure the diversity of the food system and its health outcomes. A production-oriented cluster of the project will explore environmentally sustainable options to diversity food production that specifically address the nutritional requirements identified for the target populations. This includes the development of novel and biofortified crop varieties, utilization of orphan crops with high nutritional value, and diversification of cropping systems and food processing technology. We will link these efforts with a consumption-oriented cluster exploring the consumer acceptance, food safety, and nutritional health effects of diet diversification options. The best solutions that contribute to healthy diets via diversification while also promoting environmental health will be up-scaled via a network of food system stakeholders in eight African countries. HealthyDiets4Africa will also devise communication and policy strategies to maximize outreach and impact of diversified food systems. Thereby the project will help to develop safe, healthy and affordable diets by adopting a diversification strategy that will simultaneously reduce the pressure of food production on the environment.


**Keywords:** Diversity,  food system,  underutilized crops,  cropping systems,  cons
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Wartime Demographic Engineering: War, Nationalism, and Population Politics in Putin’s Russia'.

assistant: **Concept**

WARDEM explores the interconnected, yet complex and contradictory, relationships between war, nationalism, and population politics in Putins Russia. The project provides an innovative analysis of the processes and practices that (re)shape the population in times of war, and through the war. Challenging geriatric peace theory, WARDEM examines the ways in which (interstate) war entails new demographic strategies. More precisely, it examines how, in the context of a declining and ageing population, an aggressor state may use war to expand the population by force through territorial annexation and the intake of displaced persons  a strategy that is particularly relevant when these people are seen as ethnic kin. WARDEM undertakes an interdisciplinary, systematic case study of a critical case, analysing Russian population politics in the context of the war on Ukraine, from its outset in 2014 to the end of 2023. Developing a transdisciplinary methodology that synthesises recent insights from nationalism studies, political demography, peace and conflict studies, and illiberalism studies, the project combines a focus on political discourse with an analysis of population policies  that is, citizenship, immigration, demography, and ethnic policies  as reflected in legal acts and policy documents. These policies are part of a wartime demographic engineering, which allows Russia to integrate new populations forcibly while seeking to divide the Ukrainian nation and weaken the Ukrainian state. Thus, the project develops a model linking the analysis of an authoritarian states aggressive foreign policy with the reshaping of its population and changes in its nationalist discourse. WARDEM is a timely project responding to the current challenges facing EU foreign and security policy. A rap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'International network for capacity building for the control of emerging viral vector borne zoonotic diseases' (ARBO-ZOONET).

assistant: **Innovation**

West Nile Fever (WNF), Rift Valley Fever (RVF) and Crimean-Congo Haemorrhagic Fever (CCHF) are arthropod-borne diseases of different domestic and wild animals and can also affect humans, posing a great threat to public health because of their epidemic and zoonotic potential. Their geographical distribution has expanded in recent decades. WNF outbreaks have already occurred in Europe, CCHF is endemic in many countries including Europe. In 2000, RVF, was reported the first time outside of the African continent, cases being confirmed in Saudi Arabia and Yemen. This virgin-soil epidemic raises the threat of expansion into other parts of Asia and Europe. There is a general public concern regarding emerging zoonotic diseases which has gained new relevance in the light of global warming. This is especially true regarding the spread of vector-borne diseases such as CCHF, RVF and WNF. It is imperative to work out integrated control measures which include vector control, vaccination programmes, improved therapy strategies, diagnostic tools and surveillance, public awareness, capacity building and improvement of infrastructure in endemic regions. The anticipated project will address these areas specifically aiming at: 1) creating common knowledge on the diseases, sharing and exchanging data, expertise, experiences and scientific information; 2) maintaining and expanding surveillance systems, monitoring disease occurrence, and vaccine use; 3) introducing, distributing and harmonizing disease detection and control tools; 4) disseminating knowledge and training staff of relevant third countries; 5) interlinking different scientific disciplines which look at the problem from differrent angles. A coordinated research programme including key laboratories in Europe and neighbouring count
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European ICT Environmental Sustainability Research' (ICT-ENSURE) under Seventh Framework.

assistant: **Objectives**

The internationally organized scientific community Environmental Informatics" proposes a support action. The super ordinate goal is to promote and extend the European exchange of knowledge and information on environmental issues for a sustainable environmental development based on a well-established network. The overall idea of the Support Action includes the following activities<br/>·\tTo identify relevant application areas for "ICT for a sustainable development <br/>·\tTo expand the existing network with experts from EU27+<br/>·\tTo organise two enlarged EnviroInfo conferences <br/>2008: "Environmental Informatics and Industrial Ecology" and<br/>2009: "Environmental Management Information Systems: Accessing and Providing valuable Information for companies' sustainable oriented Decision Making" (tentative) <br/>·\tbuild a database on research literature - based on EnviroInfo proceedings<br/>·\tprovide a Web based information system on European environmental sustainability research <br/>·\tto define requirements for a portal concept for the development of a "Single information space in Europe"<br/>and finalize with recommendation and a roadmap for inter-/transdisciplinary research to strengthen the EUROPEAN RESEARCH AREA in the field of ICT for environmental sustainability.<br/>The group "Environmental Informatics" provides in this Support Action long-standing experience in ICT application for communication, technology and environmental protection. While gaining additional information from other countries, an added value emerges from a growing network of experts and practitioner in research, industry, SME's and administration linked with an in-deep interdisciplinary knowledge transfer. <br/>It is certain, that after this Support Action the current independent group will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'OPerational ECology: Ecosystem forecast products to enhance marine GMES applications'.

assistant: **Concept**

OPEC will undertake research and development to develop Operational Ecology to augment the capabilities of the GMES Marine Service. Using the Marine Service as a framework, OPEC will OPEC will contribute ‘to the establishment of innovative new GMES products or applications by’ establishing the infrastructure for the performance of ecology in the European Regional Seas by implementing a prototype regional ecological Marine Forecast System in 4 European Regions (NE Atlantic Baltic, Mediterranean and Black Seas, which include hydrodynamics, lower (plankton) and higher trophic (e.g. fish) and biological data assimilation. OPEC will deliver ‘new products’ in terms of rapid environmental assessments as well as hindcasts for environmental management by providing regular ‘geo-spatially referenced’ error quantified information products (ECV’s and indicators of GES) for European Coastal Seas in both lower and higher trophic levels. By assessing the potential spatial and temporal scales of predictability of seasonal forecast appropriate to both lower and higher trophic levels OPEC will also lay the foundations for the next generation of operational ecological products. In doing so OPEC will provide high quality 3D ecosystem indicators covering a range of temporal and spatial scale appropriate for different policy needs as new service aimed at supporting policy, environmental management and other downstream services by providing error quantified hindcast estimates of the state of the environment in the recent past systems. OPEC will contribute directly to policy requirements such as the MSFD, CFP, the monitoring of climate change and to the assessment of mitigation and adaptation policies. Through engagement with SME’s, OPEC will implement new water quality related data products an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Functional analysis of eph signalling during notochord morphogenesis in zebrafish' (1994-1998).

assistant: **Concept**

Research objectives and content Cell-cell interactions are crucial to patterning and cell differentiation in vertebrate embryos. The Eph-related family of membrane-bound receptor tyrosine kinases and their cognate ligands are among candidates for mediating such cell-cell communication. Expression studies and functional analyses have demonstrated a pivotal role for the Eph signalling during the development and patterning of the central nervous system and spinal cord. The complementarity of receptors and ligands expression patterns in different regions of the embryo together with functional studies, have led to the proposal that Eph signalling acts in establishing boundaries between regions, through mechanisms of repulsion. It is likely that Eph signalling in different morphogenetic processes leads to a common set of cellular responses including control of the cytoskeleton. The aim of the proposed research is to study the functions of the Eph signalling system in mesoderm regionalisation during zebrafish embryogenesis. I aim to analyse whether Eph receptor-ligand mediated repulsion is also used by non-neuronal cells to establish boundaries, such as between the notochord and paraxial mesoderm cells, during primary axis formation. Emphasis will be given in investigating the roles of Eph signalling in mediating cell shape and cell movement changes which occur during convergence and extension movements driving notochord morphogenesis in the zebrafish embryo. Training content (objective, benefit and expected impact) The proposed research will enable me to continue and expand my interest in molecular mechanisms of pattern formation in vertebrates. Most importantly, it gives me the opportunity to acquire knowledge in zebrafish embryology and genetics as well as in new techniques
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Time-dependent design and assessment of prestressed steel-concrete composite bridges with external FRP tendons' (TimePresCompBridge) targeting Horizon 2020.

assistant: **Abstract**

Large EU projects and surveys reveal that the frequency and cost of bridge repairs in Europe have significantly increased due to traffic loads higher than those considered in the initial design, harsh environmental conditions, use of de-icing salts especially in countries with cold climates, poor quality of construction materials, and limited maintenance. Most importantly, the aforementioned projects and surveys highlight that current repair and strengthening methods are costly and time-consuming and result in large socio-economic losses due to disruption of traffic flow such as travel delays, longer travel distances, insufficient move of goods, and loss of business. Therefore, bridge owners and bridge engineers urgently seek to transfer into real-life projects more efficient and less disruptive methods for bridge repair, strengthening and maintenance. External post-tensioning is recognised as a powerful technique in the rehabilitation of existing bridges as well as in the construction of new bridges. For the advantages of noncorrosive property and high strength, fibre reinforced polymer (FRP) composites are being increasingly used for external tendons instead of conventional steel ones. Existing research on externally prestressed steel-concrete composite bridges has focused on the short-term loading. However, the inevitable loss of long-term performance of prestressed composite bridges is of primary concern in practice, especially when FRP tendons are used. Therefore, it is necessary to investigate deeply the long-term behaviour of these bridges and, on this basis, to propose practical design guidelines. In this fellowship, an experimental and numerical study will be carried out to understand the time-dependent performance of composite girder bridges with FRP tendons.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploitation of Organic Electrochemical Transistors for Biological Ionsensing' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

In biological systems many tissue types have evolved a barrier function to selectively allow the transport of matter from the lumen to tissue beneath. Characterization of these barriers is very important as their disruption or malfunction is often indicative of toxicity/disease. The degree of barrier integrity is also a key indicator of the appropriateness of in vitro models for use in toxicology/drug screening. The advent of organic electronics has created a unique opportunity to interface the worlds of electronics and biology, using devices such as the organic electrochemical transistor (OECT), that provides a very sensitive way to detect minute ionic currents. This proposal aims to integrate the barrier function of biological systems with OECTs to yield devices that can detect minute disruptions in barrier function. Specifically, OECTs will be integrated with cell monolayers that form tight junctions and with membranes that incorporate ion channels. A disruption in tight junctions or a change in permeability of ion channels will be detected by the OECT. These devices will have unprecedented sensitivity, in a format that can be mass produced at low-cost. The potential benefits of this multidisciplinary project are numerous: It will be a vehicle for fundamental research in life sciences and the development of new in vitro models for toxicology screening of disruptive agents and the development of drugs to treat disorders linked with barrier tissue malfunction (e.g. mutations in ion channels). Moreover, through the use of various cell lines and ion channels, this platform will also lead to the engineering of new sensors and biomedical instrumentation, with a host of applications in medical diagnostics, food/water safety, homeland security and environmental protection.