RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Epigenetic editing to unravel the causal function of Marks of Active Chromatin: a quantitative and mechanistic dissection' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Chromatin modifications are essential for the transcriptional programmes underpinning development and cellular identity. However, an understanding of the causal function(s) of chromatin marks in gene regulation has lagged behind. Particularly, whether chromatin modifications linked with active transcription (active marks) have a causal function remains intensely debated, while the underlying mechanisms are poorly understood. This is due to technical limitations in the ability to precisely perturb chromatin marks in a locus-targeted manner.  In this project, I will leverage cutting-edge (epi)genomic tools to systematically dissect the causal roles of key active chromatin marks—H3K4me3, H3/H4ac, and H3K79me2—, at a mechanistic and quantitative level. To directly link locus-specific active mark deposition to transcriptional responses, I will employ a novel epigenome editing technology that allows precise and targeted deposition of chromatin marks. By combining this advanced tool with unbiased genome-wide CRISPR screens using the orthogonal enCas12a system, I will systematically uncover the molecular mechanisms that decode the function of active marks. Additionally, I will dissect the quantitative effects of these marks on transcription at the single-cell level using a tunable epigenetic editing platform. If successful, this proposal will provide unprecedented mechanistic insights into the role of active chromatin marks, paving the way to new therapeutic strategies that harness precise epigenetic control of gene expression.


**Keywords:** epigenetic editing, CRISPR, orthogonal CRISPR screens, chromatin marks, active marks, epigenetic mechanisms of gene activation, degrons, conditional destabilization domains, tunable epigenetic editing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Theoretical predictions and analyses of LHC physics: advancing the precision frontier' in the context of a Seventh Framework call.

assistant: **Objectives**

The primary goal of this research proposal is to push to new levels of precision the predictive power of theoretical analyses of the phenomena observed at the Large Hadron Collider (LHC) at CERN. The start-up of the LHC has opened a new era in the exploration of the fundamental laws of Nature. This is expected to lead, among other results, to the clarification of the mechanism breaking the electroweak symmetry of fundamental interactions, to the discovery of new elementary particles, possibly accounting for the Dark Matter seen in the cosmos, and to the observation of new interactions, acting differently on matter and antimatter, to explain the observed baryon asymmetry of the universe.The crucial ingredient in the success of this ambitious programme is the ability to interpret the signals extracted by the experiments.  To decode their properties and match them to the dynamics of possible new physics models relies on the numerical simulation of such dynamics, and on the ability to distinguish it from that of the known Standard Model (SM) processes. The past two decades have witnessed a continuous progress in this field, driven by the exploitation of the data from previous colliders, such as LEP, HERA and the Tevatron. The complexity of the LHC final states, the large rates of processes with many jets and their role in mimicking the production and decay of possible new particles, call for an aggressive effort to radically improve the current quality and accuracy of the theoretical modelling, to match the unprecedented discovery potential and measurement precision of the LHC experiments.Capitalizing on recent theoretical advances, driven in significant part by the work of the PI and the team members, this proposal outlines a challenging and ambitious programme to advance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Axoglial synapses, adult myelination and motor skills learning'.

assistant: **Concept**

Recently it has become clear that new oligodendrocytes and myelin are generated throughout adult life in rodents.  Some major axon tracts including the corpus callosum contain a majority of unmyelinated axons even in maturity, suggesting that at least some of the adult-born oligodendrocytes might myelinate previously naked axons.  This would be expected to alter dramatically the conduction properties of the newly-myelinated axons and the properties of the circuits in which they participate, contributing to neural plasticity.It has been known for a long time that proliferation and differentiation of oligodendrocyte precursor cells (also known as NG2 cells) in the developing CNS is controlled in part by electrical activity in axons.  More recently, it was shown that NG2 cells form synapses with axons (""axoglial synapses"") and receive electrical stimulation from passing action potentials.  This suggests that NG2 cells are “listening in” to electrical activity which, at some threshold, might stimulate them to differentiate and myelinate the active axon(s).  MRI imaging of human brain has revealed that white matter volume continues to increase into the fourth decade of life and that specific tracts can undergo structural changes in response to complex activities such as piano playing or juggling.  These and other observations raise the intriguing possibility that motor skills learning and motor memory might depend on new myelination.  Testing this startling new idea is at the core of my proposed program of research.  We shall investigate 1) the role of axoglial synapses in regulating NG2 cell proliferation and differentiation in the adult CNS and 2) the role of NG2 cells and myelin genesis in motor learning.  Behavioural, cellular and molecular analyses of genetically mani
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'EU Externalization of Migration and Border Management to Libya: the Role of Non-Governmental Organizations and Human Rights Implications'.

assistant: **Innovation**

LIBORG aims at exploring, from the perspective of the non-governmental organizations (NGOs) involved in migration-related activities, the reconfiguration of the Libyan migration and border regime since Gadhafi’s fall in 2011. Libya is a point of departure of migrants heading for Europe on makeshift boats. Italy (as the landing country) and the EU have long been trying to include Libya in the process of externalization, which aims to support countries of origin and transit in their efforts to stem unwanted migration. A crucial role in this process is played by international organizations (IOs) and other non-state actors, which: a) directly carry out activities in countries of origin and transit (e.g. refugee protection, repatriations, assistance to detained people, livelihood projects and information campaigns aimed at reducing migration); b) provide local state authorities with know-how and technical support. While a growing body of research has started analyzing this process, scant attention has been paid to Libya (as opposed to other countries) and to the role played by NGOs (as opposed to that played by IOs). Gadhafi’s fall allowed for many international NGOs to start activities in Libya, and for many Libyan NGOs to be established. Despite Libya’s political instability, their activities have increased sharply, along with the increase in funding from EU and Italy, since 2017. In 2017 and 2018, extraordinary funding was made available by EU and Italy to IOs, which typically subcontract part of their activities to NGOs. In 2018, six Italian NGOs started working in Libyan detention centres under a scheme funded by the Italian government. LIBORG will, first, map the different NGOs operating in this field. Then, it will analyze their mandates and activities, as well as the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Parkinson Disease with Mild cognition Impairment treated with Nicotinic agonist Drug' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Parkinson Disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. There is an unmet clinical need to treat Parkinson disease with mild cognitive impairment (PD-MCI). There is ample evidence from epidemiological studies as well as (pre)clinical research that Nicotinic receptors are involved in PD and cognition. Recently a clinical trial suggested that selective α7 nicotinic receptor agonist improved cognition in PD patients, as a secondary outcome measure. Hence, the main goal of PD-MIND is to show the potential of the Astrazeneca nicotinic α7 agonist AZD0328 in a randomized, placebo-controlled, international multicentre, cross-over study on cognition in people diagnosed with PD-MCI. We will assess the Attention Intensity Index composite score from the CogTrackTM system as primary outcome measure and other clinical aspects (cognition, motor symptoms) as secondary outcomes. In addition, blood, CSF and imaging biomarkers will be assessed as potential predictors of response, and as marker of target involvement. Patients (Public and Patient Involvement) and other stakeholders will be engaged from the start to allow integration of end-user perspectives in the design and execution of the project. PD-MIND will put considerably effort to disseminate and exploit clinical outcome data and biomarker results, and to sustain the partnership for subsequent phase 3 clinical studies. PD-MIND consortium consist of world-leading PD-MCI experts in the area of clinical trials, clinical coordination, project management, data management and analysis, and biomarkers. As such the consortium is well positioned to execute the proposed work and complement the EFPIA members.


**Keywords:** Parkinson Disease, PD-MCI, Nicotinic receptor, Nicotinic agonist, biomark
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'On demand prescription eye-glass lenses - laser printed in the shop while you wait!' under Horizon 2020.

assistant: **Concept**

ODYSSEY will disrupt the prescription eye-glass lens value chain.  We will exploit the novel ultra-high-resolution on-resonance laser printing technology, developed by ODYSSEY partner DTU in FET OPEN CHROMAVISION. Early innovation activities to analyze the business potential of our laser printing technology were conducted in FET Innovation Launchpad DeLight. This resulted our business idea: To introduce on-demand, ultra-thin and light-weight prescription eyeglasses, laser-printed in the shop while you wait. With this business vision, we won the Excellent Science category of the H2020 Innovation Radar Prize in 2018.  DTU has filed two international patent applications on the ODYSSEY technology. The main project activities will be: (1) Develop our business plan (2) Research and technology development to demonstrate prototype prescription glasses (3) Validate prototype prescription glasses with clients in the optician’s shop (4) Specify product and supply chain for university spin-out to be launched in continuation of the project.


**Keywords:** Prescription lenses, nano-optics, nano-fabrication, laser manufacturing, on-demand eye-glasses
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Coordinated Observational and Numerical Studies of InterStellar Tracers' under Seventh Framework.

assistant: **Concept**

The dynamical and chemical evolution of diffuse interstellar gas is a key process in the development of structure in the Universe, leading to the subsequent production of stars, planets and ultimately, life itself. The goals of this research programme are to bring together the most comprehensive, detailed astrophysical data of the neutral phases of the interstellar medium in our Galaxy and the most complete current model of their dynamical and evolutionary relationship. Our observational data are from new, forefront international observational initiatives at multiple wavelengths, while our numerical  magnetohydrodynamic models of our entire Galaxy uniquely include spiral structure,  multi-temperature and multi-phase capability through the addition of CO and H2 formation from the atomic gas. The key advances enabled by the numerical models are the ability to  visualize and quantify the time evolution of important ISM structures (e.g. molecular clouds) and reveal the observationally invisible molecular hydrogen component. The models provide  context for understanding the observational signatures of particular stages of evolution  (e.g. HI self-absorption clouds, infrared dark clouds) that are of current great scientific interest. The detailed observational data in turn allow tests of the spiral shock model of molecular cloud formation (thought to be the dominant evolutionary path) in terms of (e.g.) the kinematic structure of CO and HI emission, the amount of HISA produced for given model parameters, the reproduction of the molecular cloud size-linewidth relation, and other measures. There are many avenues for the development of this  core research, both observationally and theroretically, that will extend beyond  the nominal duration of the project. The models and data t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Better Addiction Medicine Education for Doctors' under Horizon 2020.

assistant: **Concept**

Drug and alcohol addiction cause a significant social and economic burden globally. Adequate diagnosis and treatment by general practitioners fails, in part due to a lack of knowledge and accredited training in addiction medicine. In Ireland, the training of general practitioners in identifying and treating addiction is lacking. Internationally, a number of initiatives to address this challenge have emerged, including a specialised training programme in Canada (www.addictionmedicinefellowship.org).To build on these initiatives, the goal of this project is to establish the feasibility and acceptability of training primary care practitioners in addiction medicine, and, in particular, how international models of addiction medicine training might inform the future development of general practice education in Ireland. Specifically, the proposed fellowship seeks to increase incorporation of new understandings about addictive disorders from multiple disciplines into undergraduate and postgraduate medical curricula. The disciplines include public health, general practice, psychiatry and health services research.The programme will involve three phases:1. the outgoing phase will study the Canadian addiction medicine fellowship and its rigorous evaluation strategy: a Novel Evaluation of the Fellowship in Addiction Research (NEAR).2. The transition phase will consult the experts and assess educational needs in both systems.3. The re-entry phase will use the knowledge from Canada and educational needs assessments to develop and pilot-test a multidisciplinary translational environment focused on increasing knowledge of the prevention and treatment of drug and alcohol addiction by general practitioners.This proposal improves addiction education for doctors and responds directly to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Simulating the Dark Universe', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

One of the most challenging tasks for theoretical and observational cosmology in the next decade will be to understand the fundamental nature and properties of Dark Energy and Dark Matter. To this end, several ambitious observational programs are presently ongoing or have been planned for the near future, with the aim to reach unprecedented accuracy in the investigation of the dark sector of the Universe. The large wealth of high-quality data expected from these wide surveys will however require equally reliable and accurate theoretical predictions for different and competing cosmological scenarios in order to exploit at best their potential discriminating power.Such predictions often need to rely on large numerical simulations of structure formation which require sophisticated algorithms and the use of large supercomputing systems. However, while suitable simulation techniques have now been firmly established for the standard cosmological model, new algorithms and new simulations are needed in order to provide a comparable set of predictions for a significant number of alternative and competing scenarios. The present proposed research program aims at developing suitable numerical codes and perform large simulations for a wide range of non-standard cosmological models, ranging from dynamical Dark Energy scenarios, to Modified Gravity Theories, to alternative Dark Matter particle candidates or different types of primordial non-Gaussianity. Without such effort the discriminating power of any observational enterprise would not be exploited at best and might fail to shed light on the Dark Universe. The present proposed research plan is therefore an essential step to provide a direct link between theory and observations in cosmology, with a particular relevance for the succe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bacterial dynamics and abundance; quantitative coupling of hydrocarbon degradation and specific bacterial communities' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Industrial development has led to exponential increase in fossil fuel consumption. This has caused serious damage to environment and needs proper management. An understanding of the relationship between hydrocarbon pollution and microbial diversity will be useful for developing predictive and effective models for biological treatment of polluted environments. New molecular tools that provide a clear picture of the relative abundance and dynamics of microorganisms in natural habitats are now in use to study microbial ecology. These have shown that Alcanivorax like bacteria appear to be globally significant in the removal of aliphatic hydrocarbons, and may be key players in the bioremediation of oil impacted environments. The objective of this project (BACTOI L) is to establish quantitative relationships between hydrocarbon removal and the dynamics of Alcanivorax spp. to inform the development of new models for biological treatment of oil-impacted environments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Control of entangled electron spins on a chip' (CEESC) targeting Seventh Framework.

assistant: **Abstract**

The promise of nanoscience stems from the fundamentally new behavior that emerges at the nanoscale. Here, we propose to explore, control and exploit one of the most dramatic aspects of this unusual behavior: quantum entanglement of spins. Our nanoscale system of choice is an array of semiconductor quantum dots that each contain one single electron. Thanks to a string of recent breakthroughs, it is now possible to initialize, coherently manipulate and read out the spin state of one such electron, and to couple it coherently to a spin in a neighboring dot. Today, we are at the brink of a new era in this field, in which entanglement will play the central part. The primary goal of this proposal, therefore, is to experimentally demonstrate that electron spins in quantum dots can really be entangled, and to control this entanglement in time. We will then use this capability to implement various quantum information protocols such as quantum algorithms and teleportation, which intrinsically rely on entanglement to realize tasks that are classically impossible. In order to push the level of coherent control to its limits, we will suppress fluctuations in the normally uncontrolled spin environment, and pursue novel quantum dot technologies which offer an intrinsically ‘quiet’ environment. Our long-term dream is to demonstrate that the accuracy threshold for fault-tolerant quantum computation can be reached in this system, which would permit quantum coherence and entanglement to be preserved indefinitely. This research is presently very much at the stage of exploratory research and is bound to produce surprising and unexpected outcomes. Furthermore, we are convinced that pushing the frontier of quantum control in nanoscale devices has a real potential to lead to future quantum tec