RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Runtime for Adaptive and Extensible Wireless Wearables' (2WEAR) targeting Fifth Framework.

assistant: **Abstract**

OBJECTIVESIn the 2WEAR project, we explore the concept of a personal system that is formed by putting together in an ad-hoc fashion computing elements that communicate via short-range radio. Some of these elements are embedded into objects, such as watches and small hardware modules. Others have the form of more conventional portable computers, such as PDAs and mobile phones. Also, there are stationary elements, some of which may be visible, such as big screens and home appliances, while others are invisible, such as network access points and backend servers.This setting deviates from the conventional computing paradigm in significant ways. What we used to refer as the personal computer" now becomes a collection of devices that co-operate with each without relying on external infrastructure or a pre-arranged set-up. Various functions and applications are flexibly distributed on different devices, which are widely heterogeneous both in terms of computing resources and user interaction capability. And most importantly, the system configuration can be changed dynamically as devices are switched on and off, and are brought into or moved out of range. From the user's perspective, it is possible to compose the system of choice just by bringing together devices that complement, duplicate or boost each other's capability to build a more functional, reliable and powerful aggregate. This act of system configuration can be as simple as putting a device into the user's pocket to activate an application or walking away from another device to deactivate a system function. Collaborative tasks can also be activated as soon as peer devices are detected. Put in other words, everyday interactions such as "switching" to a bigger display, "adding" and "removing" applications, as well as "ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Unraveling the molecular network that drives cell growth in plants' (CELLONGATE) targeting Horizon 2020.

assistant: **Abstract**

Plants differ strikingly from animals by the almost total absence of cell migration in their development. Plants build their bodies using a hydrostatic skeleton that consists of pressurized cells encased by a cell wall. Consequently, plant cells cannot migrate and must sculpture their bodies by orientation of cell division and precise regulation of cell growth. Cell growth depends on the balance between internal cell pressure – turgor, and strength of the cell wall. Cell growth is under a strict developmental control, which is exemplified in the Arabidopsis thaliana root tip, where massive cell elongation occurs in a defined spatio-temporal developmental window. Despite the immobility of their cells, plant organs move to optimize light and nutrient acquisition and to orient their bodies along the gravity vector. These movements depend on differential regulation of cell elongation across the organ, and on response to the phytohormone auxin. Even though the control of cell growth is in the epicenter of plant development, protein networks steering the developmental growth onset, coordination and termination remain elusive. Similarly, although auxin is the central regulator of growth, the molecular mechanism of its effect on root growth is unknown. In this project, I will establish a unique microscopy setup for high spatio-temporal resolution live-cell imaging equipped with a microfluidic lab-on-chip platform optimized for growing roots, to enable analysis and manipulation of root growth physiology. I will use developmental gradients in the root to discover genes that steer cellular growth, by correlating transcriptome profiles of individual cell types with the cell size. In parallel, I will exploit the auxin effect on root to unravel molecular mechanisms that control cell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mechanisms of myelin biogenesis and repair' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

During the development of the central nervous system, specialized glia, oligodendrocytes, extend and wrap their plasma membrane around axons to form tightly packed membrane stacks that provide electrical insulation. Axonal insulation by myelin facilitates rapid nerve conduction and is essential for neuronal metabolism. Damage to the myelin sheath as it for example occurs in multiple sclerosis results in severe neurological disability not only by slowing down nerve conduction, but also as a result of neurodegeneration. Our main goal is to develop strategies to promote remyelination in demyelinating diseases. To realize this goal we need to understand how myelin is formed during normal development. The focus of this project will therefore be on the molecular mechanism of myelination and in particular on the role of neuron-glia communication in this process. We plan to study the mechanisms of myelin membrane growth and test a novel model of membrane extension. We hypothesize that the myelin membrane grows by the lateral diffusion of plasma membrane driven by a tension gradient that is formed by membrane trafficking events. We propose that neurons control this process by regulating the balance of exo- and endocytosis in oligodendrocytes. Furthermore, we would like to test a novel model of myelin membrane assembly, in which we suggest that myelin is formed after a gradual maturation of the plasma membrane that is regulated by neurons and require MBP. We will also investigate the signalling from oligodendrocytes to neurons by analyzing the function of small membrane vesicles, exosomes that we have recently found to be released by oligodendrocytes. Our goal is to understand how these signalling systems act on the cellular machinery that generates myelin. We hope that this appr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Functional characterization of NK and DC lectin receptors' in the context of a Sixth Framework call.

assistant: **Objectives**

Dendrite cells (DC) are highly specialized antigen presenting cells (APC) that are critical for the initiation of T cell-dependent immune responses. The antigen uptake functions of DC are mediated by the expression of specialized surface receptors some of them belonging to the animal lection family. Recently, many lection receptors have been identified on the DC surface. On the other hand, natural killer (NK) cells also express lection receptors on their surface that controls its activity by a balance between inhibitory and activating signals. These NK receptors are close related to the DC lectinreceptors. Little is known about the functions of these lections. It is thought that most lections on DC are involved in pathogen recognition and presentation, however they may also mediate cell-cell interactions. Some lection receptors on NK recognize MHC-I, but the binding specify of most of them, or whether they can bind carbohydrates or pathogens is not known. The purpose of this activity is the functional characterization of new lections receptors expressed on dendrite and NK cells. We will define its carbohydrate specify and pathogen binding, internalisation ability and pathways, analysis of a possible role in cell-cell interactions and study of signalling events operated by these receptors. Detailed understanding of these processes will create sophisticated tools to inhibit, induce, or modulate DC and NK-specific responses in various diseases such as cancer, auto-immunity and infection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A privacy layer to power all research and AI workflows' to be submitted under Horizon Europe.

assistant: **Abstract**

Sarus will bring to market a privacy-preserving data solution for all research and AI projects.By leveraging generative AI and privacy research (differential privacy), the solution enables researchers and data scientists to leverage private data assets without seeing them. It acts as a protection layer between the data source and the scientist that guarantees the privacy of any computation. It supports a broad range of analysis, from analytics to AI, and blends effortlessly into existing workflows and IT infrastructures.Sarus bolsters data security and privacy, streamlines compliance processes, and unleashes the full potential of data for research and innovation.We have already demonstrated the potential and benefit of this approach with successful paid pilots with hospitals, healthcare organizations, financial services companies, and smart cities players.This projects will industrialize and robustify the solution, expand it to new forms of data and types of analysis (e.g.: LLMs) to support any data workflow in a privacy-preserving way.With Sarus, all data assets will be available to fuel innovation, growth, competitiveness, job creation, and societal progress without any compromise on citizens' fundamental rights.


**Keywords:** AI, research, privacy, security, data spaces, data protection, LLM, generative AI, cloud, differential privacy, machine learning, analytics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The game changer drug to cure alcohol use disorders' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Alcohol use disorders (AUD) is a disease characterised by uncontrolled alcohol consumption. 283 million persons worldwide suffer from alcohol mise use which cause more than 3 million dead and 132.6 million disability-adjusted life years. Alcoholism has also huge damaging effects on families, communities and the overall society. Current drug therapies against AUD are unsuccessful due to poor efficacy and strong side effects. That situation leads to low patient recovery and only 10% of AUD people seeking for treatment.  In this context, Kinnov-Therapeutics has developed a new revolutionary first-in-class drug allowing patients to control their alcohol consumption. KT-110 drug will highly impact the European burden of AUD by decreasing alcohol consumption on AUD patients by 70% leading to triple the number of AUD people seeking for treatments and save more than 5 million lives per year and several billion of social cost expenses. The efficacy of KT-110 is related to its action on a newly discovered pathway highly implicated in alcohol addiction. This major understanding of AUD addiction mechanism was granted the European college of neuropsychopharmacology Neuropsychopharmacology Award in 2009. After 20 years of intensive research and pre-clinical development, KT-110 has been accepted by the french regulatory agency for its first-in man phase II clinical trial by the end of 2018. This will be the main achievement of SMEi2 project. Moreover, all necessary actions for successful commercialisation to pharma companies (licensing deals) as well as continuous and updated IP and FTO issues are planned to be implemented during the SMEi2. Through StopAddict project KT-110 will become the next leader of AUD treatments by generating €117m of cumulative revenues between 2025-2027. Our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ultrathin Two-Dimensional Polymer Heterostructure Membranes Enabling Unidirectional Ion Transport' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Current separation technology is crucial for many aspects of human life and accounts for ~15% of the world’s energy consumption. While the particle flow through separation columns is directional at the atomistic scale, undirected Brownian motion dominates in state-of-the-art membranes. 2D membranes have the potential to overcome this intrinsic deficiency and shift the paradigm of particle transport from disordered Brownian motion to unidirectional flow.We will develop unprecedented 2D polymer heterostructure membranes (2DHMs) combined with functionalized graphene. They offer ultimate thinness (leading to shortest diffusion lengths), precision pore geometry/size (resulting in high size-selectivity, even for hydrogen isotopes), and high functionality (fostering chemical/charge selectivity and ionic gating), making them ideal membrane materials to realize selective and unidirectional ion transport. We will combine our complementary expertise in theory and prediction, chemical design, and on-water/liquid surface synthesis, as well as in-situ ion transport investigations to develop robust 2DHMs.We will synthesize 2DHMs in the form of horizontal and vertical heterostructures, for which reliable structure-property correlations will be established. We will take advantage of lattice vibrations, nuclear quantum, and electrochemical effects, and consequently reformulate classical diffusion theory to consider these game changers. As a result, we will achieve innovative 2DHMs for selective proton and ion transport with high permeance, laying the foundations for the next-generation membrane technologies.2DPolymembrane will unlock the unique opportunities of 2DHMs for innovative energy device integrations (proton/aqueous metal batteries, fuel cells, and reverse osmotic power generator
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Stanley Grange Medieval Iron Project: Production, Exchange, and Technology Transfer in Medieval Europe', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

European iron technology changed dramatically during the Middle Ages, as the ancient but inefficient “bloomery” production technique was gradually succeeded by the blast furnace. Such technological developments had a dramatic impact on European society and economy, and facilitated many of the developments of the subsequent Industrial Revolution. Unfortunately, we lack information on some of the fundamental issues underlying this transition.   The applicant, Dr. Patrice de Rijk, will examine these issues through the scientific analysis and historical contextualisation of the important medieval iron smelting site at Stanley Grange, Derbyshire, UK. As a result of his research, important new insights will be developed into the progression and transfer of medieval iron technology, and of the economic and cultural ties that bound together individuals, institutions, and states in pre-modern Europe.  The tangible benefits of the research are numerous:   1) For the host institution (the University of Nottingham), the applicant’s research represents the addition of new technical and intellectual expertise. It will facilitate the conversion of a forgotten post-excavation backlog stored in the University Museum into a primary research resource.    2) For the applicant, the unique combination of expertise in medieval archaeology and ancient materials at Nottingham will have a clear and measurable benefit to his intellectual development. By conducting his research, teaching, and working within a UK university, the applicant’s chances of achieving long-term re-integration into European academic life will be dramatically improved.   3) For the European Research Area, the research and training will produce one of the very few scholars with pan-European expertise in medieval iron technol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Methodologies and Data mining techniques for the analysis of Big Data based on Longitudinal Population and Epidemiological Registers' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

European societies face rapid social changes, challenges and benefits, which can be studied with traditional tools of analysis, but with serious limitations. This rapid transformation covers changes in family forms, fertility, the decline of mortality and increase of longevity, and periods of economic and social instability. Owing to population ageing across Europe, countries are now the experiencing the impact of these rapid changes on the sustainability of their welfare systems. At the same time, the use of the space and residential mobility has become a key topic, with migrations within the EU countries and from outside Europe being at the center of the political agenda. Over the past decade research teams across Europe have been involved in the development and construction of longitudinal population registers and large research databases, while opening up avenues for new linkages between different data sources (ie administrative and health data) making possible to gain an understanding of these fast societal transformations. However, in order to work with these types of datasets requires advanced skills in both data management and statistical techniques. LONGPOP aims to create network to utilize these different research teams to share experiences, construct joint research, create a training track for specialist in the field and increase the number of users of these large – possibly underused - databases, making more scientists and stakeholders aware of the richness in the databases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'A novel micronutrient-based strategy to prevent hearing impairments: test and road to market for age-related hearing loss and preservation of residual hearing'.

assistant: **Innovation**

Hearing impairment affects 600M people worldwide.  It greatly decreases quality of life, particularly in the elderly, and constitutes an unmet health and medical need.  Regeneration of sensory auditory hair cells is not available as a medical technology.  In concordance with this topic call, we propose a novel strategy based on the development of a new technology, a micronutrient formulation implemented as a pill, to prevent damage, and perhaps recovery of auditory hair cells.  This SME-driven  program is based on the scientific rationale that free radical formation and blood flow reduction underlie cell death in sensory systems in response to environmental stress and  with aging.  In the auditory system, the stress of intense noise, drugs, cochlear implantation and aging lead to excess free radical formation, blood flow reduction, inner ear sensory cell loss, and irreversible hearing impairment.  Our aim is to demonstrate that a proprietary combination of antioxidants (Vitamins A, C, E) and a vasodilator (Mg++) effectively prevent/treat: 1) hearing loss in the elderly and 2) loss of residual hearing in the elderly and patients receiving cochlear implants.  A combination of human trials and animal studies will create a pathway to market and effectively translate this new technology to human application.