RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Egr1 and Egr2 regulate opposite transcriptional programs in macrophages' (MacrophageEGR).

assistant: **Concept**

Macrophages play important roles in many aspects of immunity and therefore contribute to a diverse range of human inflammatory diseases, including atherosclerosis. The expression of macrophage genes is tightly controlled by regulatory DNA elements, such as enhancers. When macrophages are exposed to external stimuli, specific transcription factors affect enhancer activity, thereby impacting macrophage function in health and disease.I am investigating macrophage enhancer activation by interleukin-4 (IL-4). IL-4 is an important anti-inflammatory cytokine that suppresses macrophage activation and regulates immune responses during parasitic infections and allergies. I discovered that IL-4 activates the transcription factor Egr2 leading to specific IL-4-induced enhancer activation in macrophages. I surprisingly noticed that Egr1, while binding highly similar DNA motifs as Egr2, actually represses enhancer activity when macrophages are exposed to pro-inflammatory stimuli, indicating antagonistic effects of Egr1 and Egr2. By targeting transcriptional regulators, macrophages can be skewed to disease-favorable phenotypes. I here propose to investigate and target Egr1 and Egr2 in pro- and anti-inflammatory macrophage phenotypes in vitro and in disease.Aim 1: To elucidate the molecular mechanism resulting in differential outputs of Egr1 and Egr2 binding, I will study the transcription factor complexes in which Egr1/Egr2 function.Aim 2: To characterize the function of Egr1 and Egr2 in macrophages, I will study the effects of Egr1/Egr2 deletion in mouse and human macrophages.Aim 3: To study the roles of Egr1 and Egr2 in macrophage-driven diseases, I will delete Egr1/Egr2 in macrophages and assess the effect of deletion on atherosclerosis and endotoxemia.My proposed studies will revea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Pure, separated hydrogen from shift processes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

PuSH – Pure, separated hydrogen from shift processesHere, I plan to exploit recent innovations made in my ERC Advanced Grant, SPeED, on the cyclic operation (or chemical looping) of chemical reactors to deliver transformational processes for chemical conversions relevant to the energy sector.  We have recently shown (Nature Chemistry, 11, pages 638–643 (2019), video at http://nuvision.ncl.ac.uk/Play/18143) that a chemical looping reactor can produce pure, separated streams of carbon dioxide and hydrogen for a water-gas shift process (a key chemical process in hydrogen production) if and only if a non-stoichiometric oxide is used as the oxygen carrier material (OCM).  Such new chemical looping processes have the potential to be a transformational development for the chemical industry and associated energy technologies because of the inherent carbon dioxide capture.


**Keywords:** Hydrogen, carbon capture, process engineering, reaction engineering, chemical looping
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A Unified Approach to Evaluating Cellular Immunotherapy in Solid Organ Transplantation' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Preventing immunological rejection of transplanted organs without the need for long-term use of pharmacological immunosuppression is a primary objective in transplantation medicine. Reducing the need for immunosuppression would dramatically improve the outcome for transplant recipients and reduce health costs for society. The means to achieve this goal has not been realised with pharmacological or biological agents yet. Conditioning the immune response of solid organ transplant recipients towards allograft acceptance using cell-based therapies is now becoming technically feasible and clinically promising. The central focus of our proposed cooperative work programme is to produce distinct populations of haematopoietic regulatory cells and comparatively test their safety and efficacy in minimising pharmacological immunosuppression in solid organ transplantation. Preparations of regulatory T cells, macrophages and dendritic cells will be licensed for clinical manufacture in outstanding research facilities across Europe, and subsequently, these different tolerance-promoting cell types will be assessed in a single Phase I/II clinical study for safety, clinical practicality and efficacy. The therapeutic potential of these cells will be directly compared using one, single clinical protocol. In addition, we will study the tolerogenic characteristics of these regulatory cell types at in-depth molecular and functional levels. These integrative, but very focused, research plans are expected to result in the identification of the most promising regulatory cell products for further testing, and commercial exploitation: the final outcome is to identify a cell product which has genuine potential to induce operational tolerance if correctly applied in a Phase IIb clinical trial. This o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Bactofruct: development of biological pesticide against fire blight'.

assistant: **Objectives**

Fire blight is a very contagious fruit (apple and pear) cultivation disease causing a yearly damage in the European Community of approximately 300.000.000. The bacterium Erwinia amylovora causes fire blight. To date no effective way to control and fight fire blight is available. The currently used pesticides consist of environmentally harmful (bio-) chemicals like Streptomycin. Streptomycin is also used as a antibiotic against lung-tuberculosis for humans. The European Community is expected to ban the use of Streptomycin against fire blight because of the risk of the occurrence of immunity.SME-companies ECOstyle (the Netherlands), Dr. Schaette (Germany) and New biotechnic (Spain) have teamed up for a project with the objective to develop a sustainable biological pesticide against fire blight. A pre-screening by University of Konstanz, one of the RTD-performers, has shown that the bacterium species Bacillus subtilis has the antagonistic potential to be used effectively against fire blight.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Access to ICT Investors'.

assistant: **Objectives**

ACCESS-ICT will address the current challenges related to access to finance for ICT SMEs involved in Framework programmes by providing a sustainable platform offering access to awareness raising solutions through to case by case introductions of SMEs to investment opportunities across Europe. This will be achieved by way of both investment readiness and access to finance tools tailored to the needs of theses SMEs. This platform is driven by the investment community, aiming to involve representatives from the financing world during the development of the tools and delivery of hands on mentoring support and in directly funding investment ready companies. The project will act as a hub between SMEs looking for access to investment and early stage and later stage investors (comprising business angels, venture capital firms and corporate investors) interested in the great potential represented by those SMEs with a strong R&D focus and beneficiaries of European public support. The objective of ACCESS-ICT is to build a sustainable pan-European network of ICT investors, which will be linked both to representatives of SMEs but also of research organisations and various stakeholders who operate across Europe in favour of the development of R&D and commercialisation of R&D for ICT SMEs. At the end of the project, this platform will consist of a live network of various investors, supported by an online web-platform including tools and solutions for those to have sustainable access to information about SME companies from Framework Programme projects. While access to finance will be the ultimate objective for the most promising companies, ACCESS-ICT through a mapping exercise conducted at the outset of the project will be able to implement both awareness raising activities for relevan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Artistic robotic surface processing for stone' to be submitted under Seventh Framework.

assistant: **Abstract**

Natural stone industry has a crucial importance at European level, and the overall worldwide demand for natural stone products is experiencing a steady growth; however, in the last years globalization is transforming the competitive scenario at a fast pace, with high technology available to most of worldwide players, who are able to offer good alternatives at extremely affordable prices; quality alone is therefore not able to keep up with the price gap, and the result is that the traditional European sculpturing and artistic stone processing is becoming an endangered art.It’s mandatory that the processes of artistic stone processing urgently evolves technologically to remain competitive in the international market, maintaining the inimitable artistic touch, at the same time keeping up with the new industrial requirements in terms of productivity and lean manufacturing.The main goal of the AROSU project is to advance and facilitate traditional artisan and art-work with new technologies, helping the European stone industry to lower their production costs by automating various production steps through a new flexible production concept. AROSU will implement a novel production concept able to extend industrial robot usage as an active assistant during the complex and demanding artistic work of hard natural stone carving. This will be achieved through the implementation of a novel robot cell able to produce artistic looking surfaces by implementing the following core components. 1) new robot mounted pneumatic chisel tool; 2)automated path generation from geometry data provided by a design interface for architects and artists. With AROSU it will be possible to improve the competitiveness of the stone processing industry, by drastically increasing the production efficiency thro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Delineation of experience-dependent astrocyte-neuron cognitive dynamics' (ANCoDy).

assistant: **Innovation**

In the brain, cells called astrocytes are as abundant as neurons, but are much less understood. Over the recent years, we have begun to appreciate how closely astrocytes support the development and function of synapses, the proposed substrate of memory. One emerging function of astrocytes is their direct involvement in learning and long-term memory. Indeed, astrocytic activity is affected in major brain disorders that affect memory, such as Alzheimers disease. The overarching aim of this fellowship is to study how astrocyte-neuron coordinated activity relates to learning and memory. I propose that astrocyte-neuron activity dynamics are shaped by learning over days to support memory formation.To test this hypothesis, I will use state-of-the-art microscopy and genetically encoded fluorescent proteins, both available in the host laboratory, to record the activity of large numbers of neurons and astrocytes while mice are trained in a perceptual learning task over days. In this way, I will be able to see how neurons and astrocytes change their activity in response to learning. I will then manipulate the activity of astrocytes using clever genetic tools and light, while the mice are being trained, and monitor the effects of this manipulation on the activity of neurons and memory performance. This step will allow me to establish causal links between astrocyte activity and memory. Finally, I will use modern statistical learning techniques to explore the contribution of astrocytes and astrocyte-neuron interactions to the computational capacity of the brain. This proposal capitalizes on my strong expertise in rodent behaviour and data analysis, my knowledge and strong interest on how experience shapes brain activity, and the established microscopy and genetic techniques in the ho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Surface Heat Exchangers for Aero-Engines' (SHEFAE), addressing dissemination and exploitation.

assistant: **Impact**

The Project aim is to develop and demonstrate an advanced structural surface cooler mounted in an appropriate core fairing composite structure. Currently surface coolers are an integral feature of advanced turbofan engine designs. They contribute to achieving the best engine performance by maintaining oil and fuel temperatures within defined limits and by virtue of their mounting on the inside of the fancase they obviate the need for additional ducting of air and a control valve to switch the air on/off. The lack of ducting and control valve leads to an overall cost and weight reduction. Oil and/or fuel is cooled by the passage of cool engine bypass air flow over the air washed surface of the heat exchanger.Current surface coolers are parasitic to the existing engine structure, and occupy surfaces that can also be used for acoustic treatment to control engine noise. As such the weight, volume and efficiency of the surface cooler are all of great importance.The design and installation of a compact and lightweight structural surface cooler in a core fairing structure will contribute positively to the efficiency of the power-plant by providing the necessary oil cooling at minimum overall weight and hence optimal fuel burn..Also it is envisaged that surface cooler/composite core fairing designs will evolve that employ novel structural design, advance manufacturing techniques, potentially novel materials and new concepts in utilising air washed surfaces on the engine. The structural integration of the metallic structural surface cooler to a composite core fairing type structure has been identified as an important area for success. The joint must allow a strong load path, handle dissimilar degrees of thermal displacement and provide sealing yet being light and durable. Theref
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mental Retardation: Harnessing the  Glutamate Hypofunction Hypothesis' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Mental retardation (MR) imposes a major medical and social-economical problem in our society. It is defined as a global reduction in cognitive and intellectual abilities, which manifests before the age of 18, and is estimated to affect 1-3% of the population. The causes of MR are extremely heterogeneous and include non-genetic factors as well as genetic changes that include chromosomal abnormalities and single-gene mutations. Great progress has been made over recent years towards the identification of MR-related genes, resulting in a list of approximately 400 genes. A largely remaining challenge, however, is to connect the genetic causes of MR to processes that establish and/or modify neuronal circuit function. Because learning deficit is a constant feature of those patients, it is tempting to attribute some of MR traits to alterations in synaptic functions. This research proposal is geared towards unravelling the molecular and cellular mechanisms underlying MR, focusing on the synaptic deficits of the disease. First, I will test the hypothesis that at the cellular level, MR proteins often impinge on synaptic function, and more specifically affect glutamate receptors expression and/or trafficking. Second, I will investigate in detail how genetic deficits found in MR lead to synaptic dysfunction in vivo. Several of the currently identified genes associated with MR code for regulators and effectors of the Rho GTPase family. These findings have led to the hypothesis that abnormal Rho GTPase signaling may be a prominent cause of MR. However, how alterations in Rho signaling result in changes in neuronal connectivity and/or plasticity that give rise to MR remain elusive. To gain insight into these pathways I will use a combination of molecular biology, optical imaging and ph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Engineered mesenchymal stem cells combined with gene therapy for osteoarticular disease' (STEMGENOS).

assistant: **Concept**

Destruction of particular cartilage occurs in rheumatoid arthritis (RA) and osteoarthritis (OA) having an incidence of 1 % and 12% in the population respectively. The resulting disabilities of RA and OA have a major impact on the European economy and health. The novel genetic therapies available have a serious limitation as only targets the inflammatory process, which returns when therapy ceases and does not cure-damaged cartilage. Our hypothesis is: Restoration of joint function could be achieved by long term therapy that is both anti-inflammatory and provides for cartilage differentiation factors that facilitate and induce tissue repair using genetically engineered mesenchymal stem cells (MSC). We will genetically engineer mouse and human MSC using transcription ally regulated lent viral vectors. These cells will attach to damaged cartilage and synthetic matrices, express chondrogenic differentiation or transcription factors and immunosuppressive compounds to enable long-term tissue repair in OA and RA. Engineered cells will be assessed in vitro and in vivo in models of RA and OA. This project will deliver new therapeutics in form of nucleic acids, proteins and engineered cells. These novel technologies would be exploited commercially.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'New Floating Platform for offshore wind in deep waters.'.

assistant: **Innovation**

Wind power has established itself in recent years as a clean alternative to conventional sources of electrical generation. Reduced costs and wider deployment, especially in the European market, have led over the past decade to its use at sea. Here the wind resource is larger and more constant, allowing higher unitary power turbines. However, the marine environment itself also imposes a number of restrictions and challenges. The technology that is being deployed now is fixed to the seabed, using different types of foundations, but a large amount of wind resources are in deeper waters, where floating solutions are needed. Because of their initial higher costs, these solutions are still under development, with only three prototypes installed worldwide. The challenge nowadays is to reduce the costs of floating wind turbine structures that will ease the access to a much larger energy potential than available in land, more easily manageable and with lower visual impact.The aim of the NFLOW project is the demonstration in real conditions of a floating structure for offshore wind which will allow a reduction in LCOE (Levelized Cost Of Energy) over the current floating technology. To achieve this, it is proposed as a first objective the validation and qualifying for this technology, of a 1:1 scaled prototype not only from a technical point of view but also from economic and necessary logistics. The design has been focused on 5MW machine, with the aim of reaching 8-10MW machines when available in the future. The already mounted prototypes have wind turbines installed of around 2MW, which prevented an optimization of structures. Its performance is good, but the cost per MW installed is above of what would be acceptable for the market.From the point of view of logistics, it has opt