RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Combatting Bacterial Resistance in Europe - Clostridium Difficile Infections', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Clostridium difficile infection (CDI) is one of the most prevalent healthcare associated infections,affecting both hospitalized patients and individuals in the community; notably, there is anincreasing realization that cases also occur in subjects not recently exposed to healthcareinterventions, including antibiotics. CDI poses an extensive burden of morbidity, mortality andhealthcare resource utilization, and so requires effective prevention and management strategies.Epidemiological data are, however, limited and studies typically have examined only part of ahealthcare economy and usually have been focused on single countries/healthcare systems. Thus,there is a lack of robust, comprehensive data on the impact of CDI across countries in Europe.Furthermore, we know that large variations in the frequency of testing and the sensitivity of CDIdiagnostics across European countries mean that the size of the problem is underestimated.Combating Bacterial Resistance in Europe-CDI (COMBACTE-CDI) therefore aims todevelop a detailed understanding of the epidemiology and clinical impact of CDI across multipleEuropean countries. Our project proposal provides a collaborative approach comprising threescientific work packages (WPs). A large epidemiology study will be undertaken across Europe inWP1 to quantify the burden of CDI (incidence, distribution, recurrence, morbidity, mortality,transmission) across the whole healthcare economy. This will be followed by a case/control study inWP2, which along with data collected in a questionnaire will enable the consortium to assesscurrent practices in Europe (guidelines, testing, surveillance, treatment, cost) and their potentialimpacts. WP3 will create a rich, European, research platform that will provide support for futureproof-of-concept and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mimotopes of carbohydrate antigens as possible vaccines against bacterial and parasitic infections' (1994-1998).

assistant: **Innovation**

We have recently demonstrated that peptide mimics, i.e. mimotopes, selected through the screening of phage-displayed peptide libraries using a protective monoclonal antibody directed against a carbohydrate antigen of an intestinal pathogen, induce upon immunization anti-carbohydrate antibodies. Therefore, mimicking of non-protein ligands can be achieved through screening random peptide libraries where the specific sequences are identified using a purely combinatorial approach, without any structural information of the original target. These data suggest that a novel class of subunit vaccines to polysaccharide antigens, based on the use of selected mimotopes as immunogens, might be developed. The proposed project plans to evaluate this mimotope-based subunit vaccine strategy for two human intestinal pathogens. Its unique and essential feature is to propose the development of anti-polysaccharide vaccines which do not require knowledge on, purification or synthesis of the original target. The proposed project cannot be carried out by a single research group. The best chance of success is through the development of a transdisciplinary network that involves groups with expertise in molecular genetics of and immunity to pathogens, in phage-displayed peptide technology, in delivering of immunogens for the induction of systemic as well as mucosal immunity, and in adjuvant molecules. The transeuropean network we propose here is more than the simple sum of its composing groups of experts. It proposes a synergistic and creative collaboration which represents the only way to efficiently tackle modern vaccinology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Electronic transitions and electron transfer in a photosynthetic reaction center' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content The two basic objectives of this project are the following: | 1 ) asses a model to describe the best we can all single subsystems that are present in a Photosynthetic Reaction Center (RC). In this preliminary part we will refine the parameters to simulate chromophores consistently with their structural and spectroscopic data. A model of polarization will be introduced to account for solvent polarization effects on electronic transitions and the static charge model will be verified; 2) with the above refined models we will be able to investigate the effect of the environment on electronic transition of RC. The use of molecular dynamics simulation with an exact calculation of the electrostatic interactions and a multiple time scale method we will allow to carry out simulation for the entire system (about 35,000 atoms). In the framework of the spin-boson model we will compute the energy gap function and its related electronic spectra. In this fashion we hope to gain insights, at the atomistic level, in the mechanism which drives electron transfer in the RC. Training content (objective, benefit and expected impact) At the end of this project a vast experience in the application of numerical methods to the study of important problems relevant to biophysics will be achieved. In particular molecular dynamics, ab-initio and sempiempirical methods, and computation of optical properties from a serniclassical point of view. A benefit from the high multidisciplinar scientific level of the host institution will be a absolutely unique experience for future activitjes. Links s with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Solid Oxide Fuel Cell micro-CHP Field Trials' (SOFT-PACT) under Seventh Framework.

assistant: **Objectives**

A consortium has been formed to validate solid oxide fuel cell (SOFC) micro CHP technology in a real market environment. The consortium consists of a utility company, a heating system manufacturer, a fuel cell company and a software company specialising in microgeneration control systems and virtual power plants. The project consists of two phases:Phase 1: Deployment of forty BlueGen™ 2 kWe SOFC generators with domestic hot water cylinders or thermal stores (Pathfinder systems). Subject to location a boiler upgrade may also be includedPhase 2: To design, build and deploy sixty 1-2 kWe SOFC micro-CHP units based on current prototype test systems (integrated systems with condensing boilers)The SOFC Technology chosen has a very high electrical efficiency (initially 60% LHV) and low thermal output which allows for 24/7 operation throughout the year. Deployment of units will be in occupied residential locations with a small number also being installed in test homes to provide reference data with the existing tests of prototype units and as a baseline for the field trial systems.The field trial demonstration will last for 36 months and provide the following outputs1.Power generation export to the grid from fully integrated Fuel Cell systems and fleet management2.Systems capable of being integrated into a future Smart Grid3.Component optimisation and supply chain development;4.Installation and field support workforce training and capability build;5.Systems capable of integrating into existing power and heat infrastructures;6.Validation of the system efficiency, cost and lifetimes compared against JTI targets;7.Identification of barriers or risks hindering full commercialisation;8.Feedback to the RD&D activities on required mitigations9.Environmental sustainability via life cyc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Capturing career paths of ERC grantees and applicants' (ERCAREER).

assistant: **Innovation**

“Capturing career paths of ERC grantees and applicants” will map the road to and from excellence by shedding light on paths and patterns, differences and similarities in the career paths of women and men ERC grantees. Specifically, we will establish who are those scientists who apply to the ERC, how do they differ from the scientific population as a whole, and what distinguishes the successful from the unsuccessful applicants?  We will also chart the institutional role in shaping research careers for those with care responsibilities by considering how career breaks and unconventional career paths are represented amongst the ERC grantees with a view to uncovering best practices and institutional support for “time to care”.This study takes a long-term perspective: by looking at the careers of ERC grantees and applicants before and, where relevant, after an award; and for the scientific community as a whole recognizing the relatively recent growth in female participation in advanced higher education by examining differences between the experiences in the starting and advanced grant awards.The project will deploy a multimethod multisource approach, using both existing archival and survey data (ERCEA database, previously collected data from other scientists), quantitative data to be collected using a survey, and qualitative data to be collected using interviews.  This will enable the team to quantify career patterns and gender differences, while the interview data will enable us to comment on the lived experiences of scientists.Our dissemination activities are geared toward co-creation of actionable development and improvement of the evaluation procedures, of work-family policies, and of career support systems, as well as proactive showcasing and sharing of best practices, b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Specific labeling of ribosomal particles by dense clusters aimed at phasing crystallographic data', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

To understand the molecular basis of protein biosynthesis, crystallographic studies are being pursued on ribosomes from halophilic and thermophilic bacteria. For phasing by isomorphous replacement methods, dense heavy atoms clusters are being used. An attached undecagold cluster was already shown to possess suitable phasing power, paving the way for the use of a tetrairidium cluster, which by binding to 4-6 sites may lead to phase information at higher resolution.  I plan to specifically derivatize the crystals of the large ribosomal subunits of Haloarcula marismortui (diffracting to 2.9 A), by binding to them, in a few locations, dense and compact clusters. As there are no naturally exposed sulfhydryls on the surface of this particle, I will insert them by site directed mutagenesis after mapping these ribosomal particles and cloning, overproducing and isolating the chosen mutated proteins. Once an inserted sulfhydryl is found to be suitable for binding the clusters, the modified proteins will be incorporated into core particles. I plan to attempt the crystallization of the fully derivatized particles, and if possible to participate in their crystallographic analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Plastic in Agricultural Production: Impacts, Lifecycles and LONg-term Sustainability' (PAPILLONS).

assistant: **Innovation**

PAPILLONS will elucidate ecological and socioeconomic sustainability of agricultural plastics (APs) in relation to releases and impacts of micro- and nanoplastics (MNPs) in European soils. We will advance knowledge on sources, behaviour and impacts through cross-disciplinary research, bringing together scientists from chemistry, materials engineering, agronomy, soil ecology, toxicology and social sciences. We will transform the scientific knowledge generated into guidance on specific solutions by applying a Multi-actor approach, involving actors in the agricultural and policy sector and world-leading industries. This will enable co-creation of knowledge and provide the scientific background to enable policy, agricultural and industrial innovation towards sustainable farm production systems.We will deliver the first digital European atlas of AP use, management and waste production to estimate sources of MNP to agricultural soils. We will run integrative studies at laboratory, mesocosm and field scales in different parts of Europe to address: occurrence of AP-derived MNPs; MNP behaviour and transport in soil; uptake by biota and crops; long-term impacts on soil properties, fertility and ecological services; effects on biological and functional diversity across multiple scales; effects on plant production and quality; and socioeconomic impacts of AP-based practices. We will focus on multigenerational effect studies for relevant traditional and biodegradable polymers, at realistic and future high-exposure scenarios.PAPILLONS partners pioneered soil MNP research, host the majority of European analytical capacity for assessing soil contamination and will provide validated, high-throughput analysis for MNPs in soil. Using innovative applications of state-of-the-art analytical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'REPTiS: Responsible Extraction and Processing of Titanium and other Primary Raw Materials for Sourcing EU Industrial Value Chains and Strategic Sectors' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

REPTiS offers a sustainable and energy efficient solution for responsible extraction and processing of Titanium and other Primary Raw Materials from strategic partner countries to EU supply chains with a net zero-waste approach. The project will demonstrate the capability of Titanium extraction and processing as a Critical Raw Material in collaboration with strategic partnership country Ukraine in all stages of the value chain ranging from open pit ilmenite ore mining and carbon-free Ti powder production to full-scale deployment in the EU, thanks to the commitments of the industrial partners after the end of the project. Demonstrating an approach towards zero waste manufacturing by means of energy and resource efficiency, and by a validation using real parts from the industry, the project will go beyond the state-of-the-art in terms of maturity (from TRL 5 to 7) and hence contribute to the European Green Deal.


**Keywords:** Critical Raw Materials, Primary Raw Materials, Titanium, Additive Manufacturing, Metal Injection Molding, Product Environmental Footprint
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Power! Through Forces of Nature' under Seventh Framework.

assistant: **Concept**

As Europe and the world are faced with common global challenges, ranging from critical environmental changes to societal issues, the role of researchers becomes ever more important.  From dealing with the current economic crisis to tackling changes in nature that may permanently alter our planet, it is clear that science and innovation will be critical in taking on those challenges through knowledge and creativity. In Iceland, the power of the forces of nature is very imminent in the daily lives of people, whether it is in the form of increased seismic and volcanic activity and receding glaciers, or the positive form of ample renewable energy. Icelandic researchers have gathered an enormous amount of knowledge and experience in dealing with the forces of nature. Moreover, through research, these forces have been” tamed” to create renewable energy sources for the benefit of the citizens.The main concept of the proposal is to focus on the role of researchers in the fields of sustainable energy and forces of nature, ranging from the natural sciences to the societal implications of natural disasters, and invite them to engage with the public at large. The objective is to influence a more positive public perception of researchers as persons by portraying their many facets and facilitate active dialogue between scientists and guests at Researchers’ Night.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evolutionary processes in calcifying organisms under future warming and biogeochemical implications' (2014-2020).

assistant: **Concept**

Future global warming will impact diverse marine ecosystems. Marine calcifiers play important roles as ecosystem engineers and in the carbon cycle. Two major groups of calcifying organisms are coccolithophores and Large Benthic Foraminifera (LBF). Coccolithophores are considered to be the most prominent carbonate producer in the ocean and also contribute about 50% of global primary production. LBF are major calcifiers in reef and other shallow marine environments. This group is usually characterised by algal symbiosis, making them contributors to primary production in tropical to subtropical areas. Understanding the response of these organisms is imperative as their ability to calcify and photosynthesis have major biogeochemical implications.An important mechanism that allows organisms to cope with rapid climate or local environmental changes is physiological plasticity both within ontogenetic development and across generations. Transgenerational plasticity is specifically relevant when trying to understand the possible impacts of climate change since these anthropogenic changes will persist across generations. Hence, one of the main challenges of studying future effects on organisms is evaluating their adaptation potential through short laboratory experiments. To overcome this challenge, we will conduct multigenerational laboratory experiments simulating adaptation under future warming scenarios and estimate predicted changes in calcification and photosynthesis. Then, we will investigate carbonate shells from warm intervals in the geological record as a field experiment of extreme warmth under natural conditions. This will validate or highlight the gaps between experimental results and adaptation under natural conditions. Our results will indicate how adaptation will m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sintering technology for nano-structured thermoelectrics' (NANOSINTHER), addressing dissemination and exploitation.

assistant: **Impact**

Thermoelectric materials are attracting huge attention due to their peculiar functional properties allowing for direct conversion of heat into electricity, solid state cooling, and sensing of thermal quantities. Nowadays, thermoelectric material performance and technology is under dynamic development aimed at improved device applications for energy converters, Peltier coolers and thermoelectric sensors. The proposal target is the development of compaction technology and optimisation of sintering conditions to fabricate nano-structured thermoelectric materials with improved performance.The experimental work will focus on Skutterudites based on CoSb3 and Bi2Te3 materials. Further highly effective thermoelectric materials like Zn4Sb3 and Clathrates will be involved. To bridge the gap between preparation of nano-precipitates and testing of thermoelectric performance, advanced compaction techniques are required to conserve the beneficial effects of the nano-structure but reaching high mechanical strength. This topic currently appears as a bottleneck to implement theoretically predicted improvement of nano-structures to thermoelectric devices and up-scaled technologies, which are promising a breakthrough in thermoelectric technology with widespread product applications.Methods applied include synthesis of nano-particles by chemical alloying, forming of compacts by cold pressing, sintering of nano-structured components by hot pressing with rapid heating rate, and subsequent characterization. Modelling work on densification and grain growth of nano-particles will provide theoretical understanding and guidelines to obtain high performance nano-structured thermoelectric materials. The fellow will deepen his knowledge and experience on compaction of nano-powders and is expected to