RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Characterization of the mechanisms of transcriptional activation by peroxisome proliferator-activated receptor' under Fourth Framework.

assistant: **Concept**

Peroxisome proliferator-activated receptor (PPAR) binds to specific DNA sequences and thereby activates gene transcription. The aim of this project is the understanding of molecular mechanisms of gene regulation by PPAR. The PPAR mediated gene activation, which has been studied in the host institute intensively, serves as a suitable model to understand general principles in gene regulation. In the host group different PPAR interacting proteins have been identified. These are the basis for different approaches to reveal PPAR mediated gene activation. Full-length cDNA of still identified PPAR interacting proteins will be obtained by phage screening and their biological role will be characterized in cell culture DNA-transfection experiments. To identify their interacting partners, proposing PPAR interacting factors will be used in vivo in a yeast two hybrid system and in a new in vitro system, which has to be adapted for phage screening. Positive interacting factors will be analysed in an in vitro transcription assay and in cell culture and thereby, the general validity of PPAR mediated gene regulation for other hormone receptors will be tested.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Pairing Business with Scientific Expertise'.

assistant: **Innovation**

Universities in Europe are generating an estimated €18 billion in revenues from contract research, consultancy, and use of facilities and equipment. This is expected to grow as urgent global challenges such as climate change create huge demand for new technologies, data, and materials. Also the EU and national governments are increasingly promoting academic-business collaborations to boost the knowledge economy. However, a remaining problem is that many businesses still have difficulty finding scientific experts, equipment, data, and materials across the globe. Whereas some online platforms exist to match business needs to freelance scientists, there is a lack of services to find expertise and assets for collaborations within universities and organisations, leaving a huge market largely untapped. Therefore, we are developing QuestPair, an online platform where businesses can post their scientific and technological needs, to which scientific experts can propose projects and suggest equipment, data and materials. Universities on QuestPair can directly participate in the negotiation of pricing and contracts. We believe that QuestPair could potentially facilitate around 6000 years of project work within the next 6 years, while reaching yearly revenues of ~€40 million. The QuestPair team combines research and data analysis skills with expertise in business, consultancy and software development. We are already developing a minimum viable product (MVP) and are receiving positive feedback from the scientific and business communities. This feasibility study aims to create a detailed picture of mediation/brokerage services that companies, scientific experts and universities need. We take an iterative approach, where we conduct questionnaires and market research, implement the res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cold-Water Coral Community Dynamics' to be submitted under Horizon 2020.

assistant: **Abstract**

Mounds and margins on the North Atlantic host highly diverse and structurally complex megabenthic communities, such as cold-water coral (CWC) reefs. These communities have been widely impacted by fishing activities, and thus CWC reefs are identified as vulnerable marine ecosystems in need of protection. Recently, several deep-sea environments (e.g. mounts, canyons) hosting CWC reefs, in EU Atlantic waters have been integrated in Marine Protected Areas (MPA). However, few of these MPAs have incorporated management plans. To establish suitable management policies, it is required to implement monitoring strategies that account for these diverse community dynamics and how they may be influenced by environmental drivers. Particulate organic carbon (POC) fluxes are known to shape deep-sea benthic communities, indicating that variations in food supply is a major driver affecting community structure and dynamics. Yet, the relationship between POC fluxes and benthic community dynamics at different temporal and spatial scales are not fully understood. Elucidating deep-sea benthic community dynamics, represents an important challenge for future research especially as management of human impacts becomes a priority. This project’s main goals are to assess the dynamics of CWC communities in mound and margins on the North Atlantic, and examine how different environmental factors may be influencing them. Community dynamics will be assessed via convolutional neural networks which will allow to assess changes in community composition and structural complexity on 3 areas that have been monitored with benthic platforms equipped with HD cameras and several environmental sensors during several months (12 – 24 months). This project will be of wide scientific interest as it will provide insigh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of a novel approach in hazard and risk assessment or reproductive toxicity by a combination and application of in vitro, tissue and sensor technologies' to be submitted under Sixth Framework.

assistant: **Abstract**

Validated alternative test methods are urgently required for safety toxicology of drugs, chemicals and cosmetics. While some animal tests for topical toxicity have been successfully replaced one by one by alternative methods, systemic toxicities require new test strategies in order to achieve an adequate safety level of the consumer. In the project, ECVAM takes the lead to manage the development of a conceptual framework in the area of reproductive toxicity. The involvement of all stakeholders in the Project Board including the European Consensus Platform on Alternatives (ECOPA), European regulators, OECD, and Industry guarantees an efficient problem solving approach. Reproductive toxicity offers the opportunities that: i) a substantial number of animals are currently required in in-vivo assays; ii) the reproductive system can be broken down into well-defined sub-elements covering the reproductive cycle; iii) a number of pioneering alternatives have already been developed; and iv) the same animal experiments are carried out for drugs, chemicals and cosmetics.The project is composed of four elements, i.e.a) technological development of in vitro andb) sensor technologiesc) the strategical development of a conceptual frameworkd) the dissemination and implementation activities.The project will develop the concepts required to compose testing strategies via the continuous implementation of novel in vitro and in silico alternatives. Problems to be solved include the development of substantial numbers of alternative test methods making use of advanced technologies. This approach requires the dimensions of a transnational Integrated Project, involving some of the most prominent reproductive toxicity research groups in the EU, close monitoring by and input from the regulatory co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'MAterials solutions for cost Reduction and Extended service life on WIND off-shore facilities'.

assistant: **Objectives**

MAREWIND addresses the main aspects related with materials durability and maintenance in offshore structures which consequently suppose failures, misfunctioning, loss of efficiency in energy generation and which have a major repercussion in O&M costs and capital costs. With the combined forces of key-players in the current value chain of wind energy, MAREWIND cover a set of ambitious targets focused on: (1) enhancing corrosion protection systems and durability, (2) effective and durable antifouling solutions without using biocides, (3) erosion protection and mechanical reinforcement in wind blades, (4) predictive modelling and monitoring and (5) increasing recyclability. These objectives will be developed considering three main pillars addressing all those aspects related with (a) Scalable manufacturing technologies, (b) Safer-by-design materials avoiding environmental concerns and (c) standardisation aspects for effective European deployment of marketable and usable technologies. Consortium Partners and core business are one of the strongest points of MAREWIND. Technological and scientific partners (LUREDERRA, TWI, CETMA, INEGI, IDENER and INL) are experts on main areas of materials and technologies to be improved: coatings, concrete, composites, monitoring and predictive methods, thus the initial TRL 4 is assured. Companies involved cover the whole value chain on offshore wind and therefore will validate prototypes, results and costs along the project under accelerated testing and real environment. TECNAN will produce at industrial scale coatings, TSF will produce coated fastening elements, EIRE will produce prototypes of wind blades, ACCIONA will produce concrete prototypes, KOSHKIL will provide validation in maintenance, NAVAL as leading in floating will validate ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Genetic studies of pre-eclampsia in Central Asian and European populations' (INTERPREGGEN).

assistant: **Innovation**

Pre-eclampsia, one of the most dangerous cardiometabolic complications of pregnancy, claims the lives of 50,000 mothers and almost one million babies annually. Pre-eclampsia and other hypertensive disorders of pregnancy remain the second most common cause of maternal death. The incidence of pre-eclampsia in Central Asian countries is over twice as high as in western Europe. Inter-population differences in genetic variants may be partly responsible for variation in predisposition to the condition.The AIMS of the InterPregGen consortium proposal are to establish sustainable and productive collaborative links between research groups in Central Asia (Kazakhstan and Uzbekistan) and Europe (Finland, Iceland, Norway, UK); and to identify and compare the genetic variants which predispose to pre-eclampsia. We shall achieve the first aim through scientific co-operation, and through training of Central Asian researchers in centres of excellence in Europe. We shall address the limited knowledge of genetic diversity in Central Asian populations by undertaking whole genome sequencing, analogous to the 1000 Genomes project. We will establish the first pre-eclampsia biobanks of DNA and plasma samples from a total of 4000 affected women, their partners and babies, and matched control samples from healthy pregnant women, in Kazakhstan and Uzbekistan. Existing genome-wide screening data, and data generated as part of this project, from a total of 10400 maternal cases and 7800 affected babies, will be used to identify pre-eclampsia susceptibility genes. We will maximise the information available by conducting meta-analyses of maternal and fetal datasets, and examining maternal-fetal gene interaction effects.By identifying genetic variants which predispose to pre-eclampsia we will gain insi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Low Curing Temperature Powder Coatings for Outdoor Applications' (PULVERCOAT) under Horizon 2020.

assistant: **Objectives**

Our company, PULVERIT, is specialized in the developing, manufacturing and sale of thermosetting powder coating since 1973. Our extensive experience and constantly search for innovative products and new applications has enable us to be leaders in the powder coating sector in Italy. To sustain our growth we have opened over the last decade production sites in Poland (2000) and Brazil (2010), and commercial sites in Germany (2007) and Spain (2009) representing nowadays our sales outside Italy 45% of our total global business. Our main product lines comprise epoxy, epoxy-polyester, polyester and polyurethane powder coatings for general metal finishing, architectural applications, household appliances and industrial vehicles.Worldwide demand for thermosetting powder coatings has increased over the last few decades based on their well-known characteristics such as excellent durability and finish, easy application and low environmental impact. The most important thermosetting resins in the powder coating market are epoxies and polyester, which cure between 180º and 200ºC depending on the combination and the cross linker used. Epoxies are preferred for their overall physical properties, while polyesters exhibit better outdoor weathering properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel CPV system fit for mass production, for electricity costs beyond grid parity and for applications in B2B, industrial and residential areas' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

CPV4ALL propose an innovative solution for concentration-based photovoltaic electricity beyond grid parity kWh prices and is oriented on short term results. CPV4ALL aims towards large scale replication in 2015 so that the demonstrated technologies will quickly lead to market deployment and thus significantly contribute to the EU energy and climate change policy (20-20-20 targets by 2020).CPV4ALL focuses on demonstrating and validating, at industrial scale, the production technology for the components and the assembly technology for the CPV modules and system. The developed CPV systems itself will undergo extensive evaluation programmes at test sites and real situations by CEA-INES.In order to realize the concepts and objectives described in the previous sections, a structure of six work packages has been defined. WP1 is focused on RTD activities and deals with the development and optimisation of the system components. In WP2-3-4 the necessary demonstration activities will be defined and developed. WP2 is dedicated to the demonstration of pilot line for the manufacturing of components and module assembly for volume > 100.000 modules/yr, while WP3 focuses on the demonstration of high-throughput manufacturing processes of critical system components for volume > 1 million units/yr.During WP4 will take place the demonstration and evaluation of CPV systems in various location (France, Austria, The Netherlands) and for various system configuration (Agricultural, Transport, Real estate, etc..). Dissemination activities under WP5 include also the preparation of a market deployment plan and the identification and selection of third parties. WP6 is dedicated to the project and risk management .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Immunological incompatibility as a basis for cancer curing and vaccination' (ULISES).

assistant: **Concept**

In the ULISES project, we aim at developing an immunologic-based treatment strategy where cancer cells are “reprogrammed” to become “visible” to the patient’s own immune system, which will see them as “not belonging to the body” and will attack them, emulating the allogenic response to incompatible transplants. Thus, it will constitute a “natural” treatment, as the patient’s own immune system will be used to attack cancer cells, with no drugs, chemotherapy, radiotherapy, transplants, etc., significantly reducing the treatment time to few weeks and producing minimal or almost null side effects. In addition, this “reprogramming” will lead to an “immunological-memory” avoiding future relapses (vaccine-like effect) through TIL (Tumour Infiltrating Lymphocytes) generated around the tumour microenvironment by the immune system.Porous nanoparticles (NPs) will be used as carriers for delivering a plasmid DNA cargo into the tumour cells in order to produce that “reprogramming”. These NPs will specifically recognize the cancer cells through the CD47 protein and the folate receptors beta and alpha, highly expressed on the surface of the cells. Moreover, two messenger RNAs will be used in order to avoid the side effects caused by targeting CD47 protein (mainly anaemia, neutropenia and thrombocytopenia).Finally, highlight that the ULISES therapeutic strategy will be a “global” treatment, since only with 3 subtypes of NP (one for each chosen alloHLA-A), we will be able to target the entire population for each cancer type. For the implementation and validation of this strategy, we will focus on pancreatic cancer because of its high aggressiveness, lack of effective treatments and little life expectancy, but the developed strategy will also be valid for other cancer varieties with mini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Virtual Reality in high fidelity Flight Simulation' (VR-FS) under Horizon 2020.

assistant: **Objectives**

The adoption of flight simulation slowly started after the Second World War, as a disruptive innovation in the training of aviation pilots. Its enormous potential for cost savings was the driving force for its progressive adoption. Currently, the cost of a training session in a Full Flight Simulator (FFS) is estimated to be between 5-20% of the cost of a session in a real aircraft. High fidelity (HI-FI) flight models are the core of Full Flight Simulators, as models replicate the aerodynamics that rule how aircraft fly and how they react to flight control inputs and to external physical conditions (turbulence, wind, precipitation, ...). These models represent “only” 5% of the total cost of a FFS, which is in the average of €25 million, since the hardware equipment comprises very complex motion platforms (required for 6-degree of freedom, in order to emulate movements and acceleration of a real aircraft) and aircraft cockpits (specific for each aircraft model, replicating the real instrumentation panel and flight controls) mounted on the platform.Our solution is the integration of HI-FI Flight Models in Virtual Reality (VR), creating a VR FFS that eliminates the high costs related to hardware in the current FFS, lowering the price of FFS from €25M to €125K. During the 5 months of execution of Phase 1 we will validate the technical, operational and financial viability of our solution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Personalised monitoring SYstems for Care in mental HEalth'.

assistant: **Innovation**

PSYCHE project will develop a personal, cost-effective, multi-parametric monitoring system based on textile and portable sensing platform for the long and short term acquisition of data.The patient diagnosed with bipolar disorder will be placed at the epicentre of its management, for treatment and prevention of depressive and manic episodes.The system will use wearable and portable devices for acquiring, monitoring and communicating physiological parameters, behavioural and mood correlated indexes (i.e. vital body signs, biochemical markers and voice analysis).The acquired data will be processed and analyzed in the established platform that takes into consideration the Electronic Health Records (EHR) of the patient, the parameters set up in the first stage between bipolar and non-bipolar individuals, as well as medical analysis in order to verify the diagnosis and help in prognosis of the illness.Finally communication and feedback to the patient will be performed through a direct contact with the patient and device, or by communication between physician and patient.Constant feedback and monitoring will be used to manage illness, to give patients support, to facilitate interaction between patient and physician as well as to alert professionals in case of patients relapse and depressive or manic episodes income.PSYCHE project will focus on the following objectives:i) Implementation of a sensing platform physiological and behavioural monitoring for patients with bipolar disordersii) Development of novel portable devices for the monitoring of biochemical markers, voice analysis and a behavioural index correlated to mental illnessiii) Brain functionality: in order to correlate central measures o with clinical assessment and the parameters measured by Psyche platformiv) Data