RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Designing metallopeptides for the removal of superoxide radicals' (MFROSPEP) under Seventh Framework.

assistant: **Objectives**

Oxidative stress results from an imbalance between the generation of reactive oxygen species and the antioxidant defense mechanisms. In recent years, oxidative stress has been implicated in a variety of detrimental health conditions including cardiovascular diseases, neurodegenerative disorders, and other types of age-related diseases. Evidence shows that the formation of superoxide radicals is a common denominator associated with all these conditions. Considering that cardiovascular diseases are the number one cause of death globally and neurodegenerative diseases are becoming a major health burden due to the aging of the global population, it is not surprising that a great deal of interest has been shown to develop new therapeutic approaches for scavenging these dangerous radicals. Superoxide dismutases (SODs) are endogenous metalloenzymes that catalyze the dismutation of these radicals into the less toxic dioxygen and hydrogen peroxide. Thus, they play a key role in cellular protection against oxidative stress conditions. The present proposal will focus on the design, synthesis and characterization of Mn/Fe SOD peptide mimics. The working hypothesis is that by designing peptides that contain the same metal binding sites as those present in the native SODs there is potential for developing novel structural and functional SOD mimics. To this aim, different native-like protein/peptide scaffolds will be prepared. Mn and Fe binding affinities, redox potentials and SOD activity will be determined for the different constructs with the objective of obtaining crucial structure-activity-redox relationships. The completion of this research will increase our understanding of the structural basis needed for the dismutation of superoxide radicals. As this understanding evolves and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'TAMper Resistant Sensor node' (TAMPRES).

assistant: **Concept**

As the Internet of Things (IoT) becomes a reality the trustworthiness of all its components assumes the utmost importance. The trustworthiness of any system in the definition of call 5 i.e. security, reliability etc. depends on its weakest part. When wireless sensor nodes (WSN) are included in the IoT it is likely that one of the more vulnerable parts will be the sensor nodes themselves. These devices can be attacked by standard" network based approaches but also by physical means if they are left unattended in remote sites which is the preferred application for WSN. While much research effort has been spent on improving the network security of WSN, the protection of the nodes and especially their protection against physical attacks has been, until now, neglected. We are convinced that protecting the WSN is essential since compromised nodes put the whole system at risk.TAMPRES aims to significantly improve the trustworthiness of WSN. To achieve this goal we will investigate protection mechanisms in the following areas:\tPrevention of side-channel and fault-injection attacks:  evaluation and development of appropriate counter measures while also considering the severe constraints of energy and silicon area.\tProvision of flawless implementation of lightweight cryptographic cores: development of secure and properly implemented light-weight cryptographic cores to provide uncompromised cryptographic strength to higher layers.\tAttack resistant system architecture: secure integration and partitioning of the whole system including hardware components and secure low level services.The range of protection mechanisms available will be evaluated by experiments with existing and recently manufactured ASICs. To ensure manufacturer independence, both the NXP and the IHP technolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Leptin, metabolic state and natural regulatory T cells: cellular and molecular basis for a novel immune intervention in autoimmunity' (LEPTINMS), addressing dissemination and exploitation.

assistant: **Impact**

Our Group has been investigating the cellular and molecular mechanisms involving leptin, the adipocyte-derived hormone, in the pathogenesis of autoimmunity such as experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).We analyzed the serum and cerebro-spinal fluid (CSF) leptin secretion and the interaction between serum leptin and naturally occurring Foxp3+CD4+CD25+ regulatory T cells (Tregs) in naïve-to-therapy multiple sclerosis (MS) patients. Leptin production was significantly increased in serum and CSF of MS patients and correlated with interferon-gamma (IFN-g) secretion in the CSF.T cell lines against human myelin basic protein (hMBP) produced leptin and upregulated the expression of the leptin receptor (ObR) after activation with hMBP; treatment with either anti-leptin or anti-leptin receptor neutralizing antibodies inhibited in vitro proliferation to hMBP.Interestingly, in the MS patients an inverse correlation between serum leptin and percentage of circulating Tregs was also observed. Moreover, treatment of EAE-susceptible mice with a leptin antagonist increased the percentage of Tregs and ameliorated disease clinical course and progression in proteolipid protein peptide (PLP139-151)-induced EAE.These findings show for the first time an inverse relationship between leptin secretion and the frequency of Tregs in EAE and MS.In the present project, we intend to analyze in vitro and in vivo, the relationship between leptin and Tregs in human and in animal models, studying at molecular and cellular level the effect of leptin and its neutralization on the survival, proliferation and cytokine secretion of Tregs.Despite recent advances, the precise requirements for the physiological development of Tregs such as the necessary milieu and their molec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Waste heat recovery for industrial heat intensive processes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The proposal addresses the initial exploitation of a vast business opportunity for waste heat recovery (WHR) in industrial processes worldwide. 12-25% of national energy consumption in industrial countries is used for drying, one of many processes suitable for WHR.  The industries paper, petrochemical, food, wood and plastic have a moderate calculated potential need of 4400 high temperature heat pumps (HTHP) delivering heat between 100 and 150 oC in Europe alone.There is a technology gap in the market for heat pumps delivering temperatures between 100 and 200 oC according to a comprehensive report from IERE (Stuttgart University), a necessity to fully exploit the vast potential in industrial processes. Tocircle is maturing its compressor and integrating it in a High Temperature Heat pump (HTHP) to fill this gap.The first process to address is the European potato frying industry consisting of 250 known frying lines. Their energy (gas) consumption totals 8 TWh a year at a value of 210 M€. The corresponding emission is 1.5 Mt CO2. A reduction in fossil consumption by 70% can be achieved by integrating a HTHP in the deep-frying process.The global market value of frozen French Fries is about 19 billion $ with Europe as the largest market, then North-America and Asia-Pacific. They represent the growth path for our potato frying solution.Commercial objectives: Tocircle will reach annual HTHP sales of 63 M€ in Y3 after project completion, a profit of 16 M€ and creating 100+ new jobs in Europe from the European potato frying segment alone.Technical objectives: to mature Tocircle’s patented rotary vane compressor using Evaporative Compression Technology (ECT), to integrate an ECT compressor package into a full-scale pilot HTHP system and to demonstrate the solution at one of 11 f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DEgradation TRIggered by MOdular DEsign' (DETRIMODE).

assistant: **Innovation**

The project DETRIMODE (DEgradationTRIggered by MOdular Design) aims at the development of a methodology for the modular synthesis of Targeted Protein Degradation Inducers (TPDI), designed as bifunctional molecules apt to the degradation of target proteins via recruitment of the ubiquitin proteasome system, a process with therapeutic prospects if applied to disease driving proteins. TPDIs are comprised of an E3 ligase ligand and a target protein ligand joined by a spacer (linker), to bring the ubiquitinating system and the target protein in close proximity, so to promote degradation of the latter. The formation of the ternary complex (target protein-TPDI-E3 ligase) is an articulated process influenced by a series of factors, such as ligands affinity, linker length and composition and molecular features of the proteins involved. The project tackles this endeavour in stages of increasing innovation, progressively incrementing the scope, flexibility and efficiency of modular synthetic access to arrays of tripartite molecules via protected, solid grafted intermediates, combinable with a variety of target ligands.  New chemical entities TPDIs will be generated targeting selected purinome proteins oncology-related.  This project will be pursued within the Chemical Core Technologies Dept. of a fully integrated company (NMS), engaged in the discovery and development of new small molecule based drugs. Organic and solid phase chemistry, computational and structural chemistry, molecular and cell biology, among others, will be exploited to achieve the project’s goal. In such multidisciplinary environment, this new technology will grow at the same speed with the researcher’s medchem competence, increasing the chance of mutual success. DETRIMODE outcomes will be shared with peers, whi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Javalambre postdoctoral training programme for future managers in astrophysics and beyond' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The Javalambre TRAINing programme (J-TRAIN) is a COFUND initiative that will attract four outstanding postdoctoral researchers on 48-month contracts following an open, merit-based selection process to the Centro de Estudios de Física del Cosmos de Aragón (CEFCA) in Teruel (Spain), one of the most sparsely populated areas of Europe. CEFCA offers an end-to-end astrophysics ecosystem, from data acquisition to societal outreach, anchored in its flagship large-area photometric surveys J-PAS, J-PLUS and J-VAR and its contribution to the space mission ARRAKIHS. Fellows will have access to three facilities: Observatorio Astrofísico de Javalambre (OAJ), with 2.5-m and 0.8-m panoramic telescopes optimised for large photometric surveys; UPAD, a dedicated data centre that reduces and publishes OAJ images following FAIR principles; and Galáctica, a outreach hub with museum, 80-cm telescope and 40-cm solar telescope that brings research to schools and the public.J-TRAIN has two goals: to deliver excellent science and to equip fellows with the research, multidisciplinary and intersectoral skills expected of future leaders. Each researcher will follow a personalised training plan under dual supervision, combining CEFCA mentorship with international guidance. Structured training covers project management, student supervision, research ethics, gender equality, mental health and outreach. Mobility is central: fellows rotate across OAJ (observing and engineering), UPAD (pipelines, open science) and Galáctica (public engagement), undertake two two-months international secondments, and gain industrial insight through visits to Satlantis (aerospace instrumentation), Eurecat (applied data solutions) and AstroÁndalus (astrotourism). By integrating frontier research with transferable-skill devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Formal Methods for Stochastic Models: Algorithms and Applications' (ForM-SMArt) under Horizon 2020.

assistant: **Objectives**

The formal analysis of stochastic models plays an important role in different disciplines of science, e.g., probability theory, evolutionary stochastic processes in biology. In computer science, such models arise in formal verification of probabilistic systems, analysis of probabilistic programs, analysis of game-theoretic interactions with stochastic aspects, reasoning about randomized protocols, etc. At the heart of the analysis methods are algorithmic approaches that lead to automated tools. Despite significant and impressive research achievements over the decades, many fundamental algorithmic problems related to formal analysis of stochastic models remain open. Moreover, the emergence of new technologies and the need to build more complex systems, require faster and scalable algorithmic solutions. The overarching theme of the project is algorithmic approaches for formal methods to analyse stochastic models. Our main research aims are:   (1) Finite-state models: Develop faster explicit and implicit algorithms, and establish conditional lower bounds, for finite-state probabilistic systems.  (2) Probabilistic programs: Develop efficient algorithmic approaches and practical techniques (e.g., compositional and abstraction techniques) for the analysis of probabilistic programs. (3) Stochastic and evolutionary games: Develop algorithmic approaches related to stochastic games and evolutionary games, which bring together the two different fields of game theory. (4) Application domains: Explore new application areas in diverse domains to demonstrate the effectiveness of the new algorithms developed.The projects success will significantly enrich formal methods for analysis of stochastic models that are crucial in the development of robust and correct systems. Since stochastic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ALL ELECTRIC SUBSEA OIL PRODUCTION SYSTEM [STAGE 1]' (AESOP).

assistant: **Innovation**

The aim of the project is to undertake in two stages the manufacture and demonstration of the AESOP All Electric Subsea Oil Processing System. Stage 1 will consist of Engineering design and Manufacture, Stage 2 will conclude with Assembly Testing and Demonstration. The oil industry is traditionally conservative with regard to new technology and therefore the demonstration of the System is necessary to facilitate the commercial exploitation of the technology by proving its technical viability and reliability. The objective is to move towards a first oilfield application of the system through close involvement with oil company operators throughout the project, tailoring the test procedures to suit both the operators and certifying authorities.L%This fifth reporting period is chararcterised by application engineering on the configuration of the AESOP Module for ship-lift testing and demonstration adjacent to Kockums' factory. The system has been designed to separate air from water (to stimulate the separation of gas from oil) and design reviews have been undertaken. Further design development and modification of new and existing component equipment has taken place. Meanwhile, potential offshore fields are being studied and marketing activities continue.The AESOP System is a complete subsea processing system with significant innovation in all areas:All Electric Power and Control - AESOP uses electricity as the common source for both motive power and control thereby reducing cabling and connection requirements. The removal of the hydraulic element from the supply umbilical will give the system the ability to operate in remote locations, in deeper water, and at greater distances from the control centre. Response to emergency signals is instantaneous.Modularisation - All produ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of an instrumented hammer to assess the stability of hip implant during surgery: assessment of the commercial feasibility' in the context of a Horizon Europe call.

assistant: **Objectives**

Total hip replacement is widely used by orthopedic surgeons, with more than one million procedures per year worldwide. Failures still occur because of a bad implant primary stability or to the occurrence of fractures, inducing pain and increased costs for the healthcare system. Although implant primary stability is the main determinant of the implant success, it remains difficult to be assessed in clinical practice. Impactor is based on results obtained in the ERC CoG project BoneImplant and aims at developing and validating a medical device consisting in a decision support-system allowing the surgeon to assess the stability the acetabular cup and of the femoral stem. Such medical device is needed by the clinicians in order to adapt their surgical strategy. The objective of Impactor is i) to achieve a minimum viable product (MVP) that will be validated in vitro and in anatomical subjects, and ii) to investigate its commercial potential and design a subsequent commercial exploitation strategy via spin-off creation or licensing of the technology. We will explore the possibility to license the technology to WaveImplant, an already existing spin-off of the same laboratory. The originality of the approach is to use an orthopedic hammer instrumented with piezoelectric sensors, which does not modify the clinical protocol since implants are impacted in bone. Regulatory issues will be at the heart of the development and we will work in order to clear the regulatory pathway of the future medical device. The team is constituted by members with complementary skills (including engineers, a business developer and an orthopedic surgeon expert in implantology). Impactor will allow the promotion of innovative solution and services in orthopedic surgery. The long-term vision is for the t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Surviving salinity: How do plants sense Na+?' (Sense2SurviveSalt), addressing dissemination and exploitation.

assistant: **Impact**

A major gap in our knowledge of how plants respond to soil salinity is their initial perception of sodium (Na+) ions. Salt is detrimental to plants and soil salinization is an increasing threat to global food security; 6% of the world’s total land area and 20% of irrigated land is affected by salinity. I recently discovered Na+-specific root growth responses of plants and will now exploit these to identify the elusive sodium sensing mechanism of plants. I will use an innovative approach combining genome-wide genetic screens in the model plant Arabidopsis thaliana with dedicated biochemical assays. I will identify candidate Na+-sensor genes through a natural genetic variation screen for the Na+-specific inhibition bending of the root in response to gravity (WP1). In parallel, I will follow a chemical genomics approach to find novel compounds that impair Na+ sensing, and their target proteins in plants (WP2). Subsequent complementary in silico and biochemical approaches will characterize Na+-affinity of the candidates (WP3). Selected putative Na+ sensors will be characterized in planta, by studying their localization, activity, their interactors, and by salt response phenotyping of mutants (WP4). Finally, mutant varieties of sensors will be introduced in the economically relevant crop plant tomato, to provide proof-of-concept for improving salt tolerance by modulating sensor function and implementation in crop improvement programs (WP5). The impact of elucidation of plant Na+ sensing will be monumental; it will reveal how plant responses to salinity stress are driven, and ultimately what is required to cope with salinity. In addition, it will open up new applied directions for agriculture, where improved sodium sensing modules will be used to allow crop growth on marginal