RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High resolution hydrodynamic simulations of star formation and protoplanetary disc evolution' (SPH-DISC-SIMULATIONS).

assistant: **Concept**

Understanding the formation and evolution of protostellar discs is a key ingredient in star-formation theory. Due to angular momentum conservation, almost all matter falling onto a protostellar object first accretes onto a disc-like structure. The size, ma ss and stability of such a protostellar disc determines the probability of sub- fragmentation into a binary or higher-order multiple system, as well as the properties of the planetary system that may build up in the late phases of disc evolution. We invest igate star formation and protostellar disc evolution in turbulent interstellar gas clouds using Smoothed Particle Hydrodynamics (SPH) with Particle Splitting to follow the time evolution of the system. Previous SPH simulations of turbulent clouds without P article Splitting have lead to the formation of clusters of protostars. The large-scale characteristics of these clusters greatly resemble those of observed young clusters, like the Trapezium. However, so far the numerical resolution has not been adequate for the detailed modelling of the protostellar discs. With Particle Splitting we will ensure that the numerical resolution of the simulations is always sufficient for the modelling of self-gravitating gas at all scales. This will allow us to study star and planet formation in unprecedented detail, and to investigate the complex dynamical interplay between gas on cluster scales and the evolution of individual protostellar discs on very small scales. We aim to understand the frequency of binary/multiple stell ar systems, the overall efficiency of star-cluster formation, the boundedness of such clusters, the resulting stellar and planetary mass spectrum, the probability for planet formation in the disc, and in particular, the efficiency of disc fragmentation as a me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Evaluation of the technical, commercial and patent issues regarding the use of human albumin micro-capsules containing iron oxides for magnetic resonance imaging (MRI)' under Fifth Framework.

assistant: **Concept**

Research and development of a new microcapsule contrast agent with unique properties for MRI of both, the blood pool and internal organs. This dual agent approach allows patients to receive quicker and more convenient diagnosis, earlier disease detection and significantly reduces health care spending. The current problem relates to multiple and cost-& time intensive diagnosis - intended to be reduced to a 'one step diagnosis' by this new technology. Within the Craft project (step 2) we expect to develop a contrast agent suitable for the initial stages of clinical testing. Expertise and know-how of the Imaging market is available within the SME consortium. A suitable company (RTD performer) with the required know-how of the microcapsule spray dry technology is already identified.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Baculovirus for VLPs vaccine production: from a scientific success to industrial application' under Fourth Framework.

assistant: **Concept**

The aim of this proposal is to bring, for the first time, a process of vaccine production from the existing scientific basis to industrial application. The proposed technology is based on the expression of recombinant viral empty capsids in insect cells using the baculovirus expression vector system (BEVS). Most, if not all, of these empty particles show optimal immunological properties that make them suitable candidates for vaccine production. Unfortunately, the industrial use of this technology has been hampered by several factors, including: lack of knowledge of the BEVS culture and recovery conditions for medium and large scale in insect cells, costs of the assessment of vaccine efficacy and safety under field conditions and, finally, the burden and complexity of the regulatory affairs to get the registration of a recombinant vaccine. The production of porcine parvovirus (PPV) virus-like particles (VLPs) has been selected as proof-of-the-concept" system in order to solve these problems. PPV is responsible for a major reproductive disease in pigs, which is usually controlled by vaccination. Vaccination is mandatory to get profitable pig meat production. PPV VLPs have been successfully expressed in the baculovirus system and shown their protective efficacy at the laboratory level. In a previous preparatory award we have shown that the production costs can be two to four times cheaper than a conventional system. The project aims to bring an established laboratory scale expression technology into economic, robust and reproducible pilot plan scale production and provide data about the efficacy, safety and stability of the product that guarantee the industrial feasibility of the system. These objectives will be implemented through several integrated work packages. The fir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Multi-wavelength analysis of merging galaxy clusters'.

assistant: **Objectives**

The present project is related to the study of galaxy clusters, to their formation and to the physical processes that are leading their evolution. In the hierarchical model of structure formation, clusters of galaxies form by accretion and merging of smaller sub-clusters and groups.We aim at answering to open questions about the dynamical and physical processes that act during the merging event on each component of clusters, i.e. galaxies, intra-cluster plasma and dark matter. Our two-level approach consists in:- observing in optical, X-ray and radio a sample of interacting clusters; and- reproducing by N-body and hydrodynamic simulations the evolution of collisionless matter (i.e. galaxies and dark matter) and intra-cluster gas respectively.A detailed modelling of cluster merger is very difficult at present; by comparing multi-wavelength observations to numerical simulations, we will be able to determine the stage and the geometry of merging clusters. In this way, we will obtain a sequence of clusters in different phases of the merging process; this sample will be the starting point to follow the evolution of cluster properties during their growth from poor groups to rich galaxy systems.In particular, we aim at analyzing how the process of cluster formation acts on the following: the relative distributions of galaxies, gas and dark matter; the large scale structure of clusters; both thermal and non-thermal components of the intra-cluster plasma, observable at X-ray and radio wavelengths respectively; the dynamics and kinematics of the member galaxies, and their internal properties, e.g. star formation rate and AGN activity.As clusters of galaxies are the largest organized structures in the Universe, a clear and complete picture of cluster evolution will bring fundament
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Implication of energy sensing pathways in prostate cancer biology' (PTENLKB1).

assistant: **Innovation**

Prostate cancer is among the most prevalent forms of cancer in men and the fifth cause of dead from cancer in men worldwide. Therefore, the understanding of prostate cancer biology is a key step in the development of new effective therapeutic approaches. In this line, the use of genetically engineered mouse models has been critical in the understanding of the genetic cues that regulate the process of prostate epithelial cell transformation. We have previously characterized the tumor suppressive function of the tumor suppressor PTEN in different stages of prostate cancer, from precancerous lesions to invasive cancer and metastasis. Importantly, we have shown that early and acute loss of PTEN elicits senescence response that functions as a brake for the progression of prostate cancer. Notably, prostate cancer has been demonstrated to be exquisitely sensitive to metabolic changes and to cancer genes altering metabolic homeostasis. In this proposal we aim to ascertain the role of energy sensing pathways in prostate cancer progression, with special emphasis in the crosstalk between the master energy-sensing kinase LKB1 and the tumor suppressor PTEN. Using genetically modified mice and cells, as well as pharmacological agents, we will study i) the contribution of LKB1-loss to the biological features elicited by loss of PTEN, especially the activation of the cellular senescence response, ii) the role of LKB1 signaling in the development of invasive lesions and the onset of metastasis, and iii) the therapeutic relevance of the crosstalk between PTEN and LKB1 in the prostate epithelium. In turn, this proposal aims to contribute to the development of more accurate mouse models of prostate cancer progression as well as to the discovery of potential therapeutic approaches directed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Objective-based forecast evaluations for crude oil volatility.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Oil price volatility forecasting is of major importance due to the financialisation of the oil market and the fact that the oil market participants’ decisions are based on such forecasting (e.g. oil-intensive industries, policy makers, portfolio traders, etc). Currently, forecasters predict oil price volatility using GARCH and HAR models and evaluate the performance of these models using statistical loss-functions, such as the Mean Absolute Predictive Error. Even more, the literature concentrates mainly its attention on two measures of volatility, namely the conditional volatility and the realized volatility. Nevertheless, oil price volatility users are faced with multiple volatility measures, multiple forecasting models and different reasons for which they use oil price volatility forecasts (e.g. policy making, portfolio allocation, risk management). Thus, in order for oil volatility users to make informed decisions, they need to know what the most appropriate volatility measure is and what the most accurate forecasting model is.This innovative project aims to lay the foundations for an advanced econometric model framework for the evaluation of the best oil volatility measures along with the best forecasting models, using objective-based loss functions.  The outcome of this fellowship will be a toolbox, containing the aforementioned framework. The project will have a great impact on the fellow as it will allow him to advance his existing scientific skills through the cutting-edge training in the state-of-the-art oil volatility forecasting techniques, in energy finance and in the field of consulting. Overall, the research training will allow the fellow to develop a pioneering research agenda in energy finance and will position him as an internationally recognised schola
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Quantitative Models of Cities'.

assistant: **Concept**

One of the most striking empirical regularities is the huge divergence in economic activity both across and within countries. Within countries, this is most clearly illustrated by the vast differences in economic activity between cities and rural areas. Despite this first-order economic phenomenon, the study of the economics of cities has been a niche interest for much of the 20th century. This has changed recently with the arrival of data with a high level of spatial resolution for cities and key theoretical breakthroughs. In particular, Ahlfeldt, Redding, Sturm and Wolf (2015) and Heblich, Redding and Sturm (2020) develop an empirically tractable model of location choices in cities. They show how this model can be used to estimate the strength of agglomeration forces in cities and the effect of the construction of the railways on commuting flows and city growth.This project will take our understanding of the economics of cities to the next level by innovating along four different dimensions. First, the project will combine quantitative urban models that build on my prior work with extraordinary detailed register data covering every person in Denmark. Second, the project will develop a dynamic version of the current static models and structurally estimate this model with the information available in the Danish data. Third, the rich heterogeneity that can be observed in the Danish register data will make it possible to innovate on the current state of the art, which assumes ex-ante identical workers and a single output, and allow for worker and firm heterogeneity. Fourth, the modelling and empirical work will directly address questions of first-order policy relevance. These questions include evaluating the general equilibrium benefits of improvements in urban transport
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Magnetosphere-Ionosphere Coupling and Associated Wave Activity' (MICAWA).

assistant: **Innovation**

This project will study a class of atmospheric waves (known as atmospheric gravity waves) and associated travelling ionospheric disturbances at high latitudes, along with the possible connections between this wave activity and geomagnetic activity. The project will use data obtained using the Tromso Dynasonde (electron density and ionospheric tilts) between January 2014 and December 2016. The project will fully investigate the spectral characteristics of the data, along with the statistical distribution of the propagation parameters, and their altitude and temporal variability. The final goal is to identify possible correlations between these parameters and indicators of the level of geomagnetic activity. The project is submitted by a researcher with substantial experience in the subject areas, originally gained in during his PhD studies at the University of Colorado. The applicant is seeking the fellowship to aid in his reintegration at the Institute of Space Science in Romania.


**Keywords:** Atmospheric Gravity Waves, Traveling Ionospheric Disturbances, Ionosondes, Dynasondes, Magnetosphere-Ionosphere Coupling, Spectral Analysis, Statistical Analysis, Correlation Study, Ionospheric Tilts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Characterization of the secretory path way of streptomyces lividans and its modulation for overproduction of heterologous proteins' under Fourth Framework.

assistant: **Concept**

Several expression systems are currently being investigated for the production of heterologous proteins at an industrial scale. So far, no system meets all needs, but host cells that secrete the proteins in the culture medium as correctly folded polypeptides, and which easily can be cultured in large fermenters on simple m2edia receive the most attention at present. Such systems are cost-effective, primarily due to a facilitated downstream processing. Streptomycetes are used in industry for the commercial production of various proteins. They are thus potentially interesting hosts for the secretory production of heterologous proteins. Moreover, they have many desirable features, some of which are lacking in alternative hosts: excellent secretion capacity for large proteins containing many disulphide bonds; high metabolic activity also in the stationary growth phase; extensive information on large scale fermentation; mycelial growth making culture filtration much simpler than of single bacterial cells. In addition, while many proteins can be produced through Escherichia cold and Bacillus subtilis based expression systems, there remain proteins which are impossible to produce in quantity due to deleterious effects on these host cells. Recent research shows that proteins which are toxic to these bacteria when overexpressed (e.g. cell division proteins) can be successfully produced in Streptomyces, presumably due to their physiological differences with other eubacteria. It has already been shown that the production of certain eukaryotic proteins by Streptomyces is very efficient. On the other, some of the tested eukaryotic proteins are produced in amounts too small for commercial production. The amount of proteins found in the culture medium can be influenced by the level of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Vocational identity, flexibility and mobility - in the european labour market' in the context of a Fifth Framework call.

assistant: **Objectives**

The proposal suggests a European wide research on the formation and manifestation of vocational identity (VI). The specific European economy's strength to win in global competition are peculiar work ethics like motivation, good work performance, commitment and quality V I can provide. The increasing instability of the formation of V I, due to multiple social and economic changes will be investigated. The influence vocational education programs have on the formation of V I will be analysed. The project will be carried out by 7 national institutions (England, France, Spain, Estonia, Greece, Czech Rep., Germany). The Main objective is to effect and inspire the outline of an European approach towards vocational education, suited to educate the future European workforce in the light of a modern European concept of work that integrates the advantages V I provides.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The acclimation of photosynthetic organisms to sulphur deprivation' to be submitted under Sixth Framework.

assistant: **Abstract**

Sulfur (S), phosphorous (P) and nitrogen (N) are, together with carbon (C), required by photosynthetic organisms at higher levels than other mineral nutrients. A deficiency in each of these nutrients can result in a severe decrease in crop plant productivity, resulting in stunted plants and reducing the quality and yields of seeds.The cellular machinery required to take up and assimilate these nutrients has been the subject of numerous studies for decades. Over the last several years, studies have mainly focused on regulatory mechanisms that control macronutrient assimilation and the adaptive responses associated with nutrient deficiency. The present project will mainly focus on S nutrition and associated regulatory processes in the photosynthetic model organism, the green alga Chlamydomonas reinhardtii.The study combines biochemistry, genetics, molecular biology, genomics and physiology aspects, along with an opportunity to use state of the art technology in a multidisciplinary training environment. The identification of regulatory proteins involved in nutrient stress responses (those of S, P, N and light deficiency) will contribute to our understanding of how nutrient levels influence plant growth and development.The study is likely to help guide biotechnological approaches focused on improving the efficiency of European agriculture, but will also contribute to a reduction in the use of fertilizers, thereby reducing the risks of environmental pollution, and extending or altering the range of environments in which specific plants can thrive.On the other hand, the emergent field of industrial bioproduction of H2 through S-deprived Chlamydomonas cultures is a promising way of obtaining a clean and inexpensive energy source (reducing the huge problem of genera ting enough