RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Minimally invasive suturing for vascular bore closure and heart defect repair' under Horizon Europe.

assistant: **Concept**

Cardiovascular diseases (CVDs) remain a major health problem worldwide and a leading cause of mortality, with over annual 18 million deaths. In Europe, CVDs are associated with 4 million deaths and costs of around 210 billion per year.Many surgeries to treat cardiac conditions are shifting to be minimally invasive and this is a trend expected to continue growing due to its multiple advantages over open interventions. However, as newly developed devices for transcatheter procedures become bigger they also require larger vascular access sites. A couple of devices are used in vascular large-bore closure (e.g. ProGlide from Abbott). However, they are associated with still high vascular and bleeding complications (up to 20%, depending on the operators skills). Such complications are linked to longer hospitalizations, unnecessary suffering, and greater healthcare costs (20k per patient), as well as higher morbidity and mortality.To solve this persistent unmet need in the field of cardiovascular surgery, Novelrad has specifically developed the NVCD closure device. It integrates a proprietary and revolutionary micro-suturing technology that mimics the standard surgical technique, effectively delivering a multipoint continuous suture in a minimally invasive manner. The NVCD is easy to use and enables a safer closure of large bores, potentially reducing complication rates to 3%, saving up to 15 min in the procedure, and bringing important cost savings related to same-day discharge and complications management. Importantly, with a single NVCD device large and extra-large bore closure of veins and arteries is possible (up to 30Fr).After obtaining a fully functional prototype of the NVCD and advancing in pre-clinical tests, we now aim to perform a first-in-human (FIH) study and comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovative Network for Monte Carlo Event Generators for LHC Physics' under Horizon 2020.

assistant: **Concept**

We propose a European Training Network that will provide a total of 540 ESR-months of training in Monte Carlo event generator physics and techniques, and related applications in experimental particle physics.Monte Carlo event generators are central to high energy particle physics.  They are used by almost all experimental collaborations to plan their experiments and analyze their data, and by theorists to simulate the complex final states of the fundamental interactions that may signal new physics.  We will build on the success of our current MCnetITN, by creating a European Training Network incorporating all the authors of current general purpose event generators, with the main purposes of:(a) training a large section of our user base, using annual schools on the physics and techniques of event generators and short-term studentships of Early Stage Researchers as a conduit for transfer of knowledge to the wider community;(b) training the next generation of event generator authors through dedicated PhD studentships;(c) providing broader training in transferable skills through our research, through dedicated training in entrepreneurship and employability and through secondments to non-academic partners.We will achieve these training objectives both through dedicated activities and through our research activities:(d) developing the next generation of higher precision event generators and supporting them for use throughout the LHC era and beyond;(e) playing a central role in the analysis of LHC data and the discovery of new physics there; and(f) extracting the maximum potential from existing data to constrain the modeling of the higher-energy data from the LHC and future experiments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Modal determiners' (MODALDET).

assistant: **Innovation**

Modal expressions allow us to talk about unrealized possibilities and uncertain scenarios. For instance, the sentence in (1), with the modal ""might"", describes a possible scenario compatible with the speaker's evidence.1) (Given what I know), Jones might be the murderer.The ability to construct discourses about the non-actual is a fundamental cognitive skill and one of the design features of human language (Hockett 1960). Accordingly, modality has been extensively studied in linguistics and philosophy (see Frawley 2006 and Portner 2009 for recent overviews). Until recently, work on modality had focused primarily on verbal elements (e.g., modal auxiliaries). Over the last few years, however, the semantics literature has begun to recognize the existence of a class of functional nominal items - modal determiners-  that introduce modal contents akin to the ones we see in the verbal domain. For example, the Spanish indefinite “algún” in (3) contributes information about the speaker’s epistemic state (that she does not know what book Juan bought), like ""might"" in (1).2) Juan compró algún libroJuan bought algún book‘Juan bought some book or other’This project will improve our understanding of natural language modality through a cross-linguistic description and analysis of modal determiners, thereby bringing together two classic domains of research (modality and determiners) that have had very limited overlap until now. The study will gather data from Catalan, Spanish and English, using two complementary methodologies (extraction of corpus data and written questionnaires), analyze these data using the methods of formal semantics and pragmatics, and examine the consequences of this research for the theory of modality. The last phase of the investigation will involve designin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ascertaining Barriers for Compliance: policies for safe, effective and cost-effective use of medicines in Europe' (ABC), addressing dissemination and exploitation.

assistant: **Impact**

Medication non-compliance is highly prevalent across all medical conditions, and represents a major barrier for realising the benefits of evidence-based therapies. The aim of the project is to produce evidence-based policy recommendations for improving patient compliance and subsequent better use of medicines by Europeans. Lack of consensus in the terminology used in this field impedes benchmarking of compliance-enhancing interventions. Therefore the first stage of the project will be to build a pan-European consensus on terminology and taxonomy of non-compliance. Effective interventions in this field should take into account the differences that exist between determinants of compliance with short-term and chronic treatments, and for different clinical sectors, health care settings and population segments. Therefore, not only will the determinants of patient compliance be identified in a systematic review of the literature, but also a survey across 16 European countries, and discrete choice experiment will be conducted. Then, a conceptual framework for the influential factors of non-compliance will be developed. Current practices of compliance management by healthcare professionals and the pharmaceutical industry will be compared across Europe, as well as educational programs from schools of medicine and pharmacy. Compliance-enhancing interventions will be compared in terms of practicality, clinical- and cost-effectiveness. The information gathered will be integrated, and priorities made to inform policy recommendations on strategies to improve patient compliance. The project findings will be discussed extensively with European experts, and based to the consensus obtained, the final recommendations will be formulated and presented to the European Commission and other re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structural and biophysical characterisation of insulin receptor and glutamate receptors AMPAR and NMDAR in complex with SorCS coreceptors 1 and 2' to be submitted under Horizon Europe.

assistant: **Abstract**

Type II diabetes (T2D), Alzheimer’s Disease (AD) and Parkinson’s disease (PD) are common age-related diseases, which have reached endemic levels and become a burden for the global health. Lifestyle and environment are risk factors, but cannot explain all cases - genes also predispose for these diseases. Common for T2D, AD and PD is abnormal cell function associated with dysfunction of insulin receptor, AMPA receptor or NMDA receptor. The Vacuolar Protein Sorting 10 protein (VPS10P) family contain five neural type 1 transmembrane sorting receptors: sortilin, SorLA, SorCS1, SorCS2 and SorCS3, that play a central role in control of neuronal viability and function by sorting crucial proteins. SorCS1 and SorCS2 interact with and sort IR, AMPAR and NMDAR, and genetic deficiencies for SorCS1 and -2 are associated with accelerated onset of pathology, thus implicating these receptors as critical regulators for normal cell function. However, the molecular mechanisms of SorCS1 and SorCS2 mediated sorting of target receptors are not known, and with this proposal I want to determine structures and investigate interactions of SorCS1:IR, SorCS1:AMPAR and SorCS2:NMDAR complexes. Determining the structures of transmembrane SorCS1:IR, SorCS1:AMPAR and SorCS2:NMDAR complexes by cryogenic electron microscopy (cryo-EM) we will reveal molecular details about the interaction such as the role of interacting elements at cytoplasmic tails, transmembrane helices and exodomains, and how they define specificity (SorCS1 vs. SorCS2), function and regulation. The proposed project can define new positions and in translational research that aims for drug discovery for T2D, AD and PD.


**Keywords:** Cryo-EM, structure, complex, VPS10P family, SorCS1, SorCS2, IR, NMDAR, AMPAR, membrane protein, structure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'GLObal-scale interactions between MAngrove forests and Climate' under Horizon 2020.

assistant: **Concept**

Covering 0.5% of the global coastal area, mangrove forests are among the most carbon-rich forests on Earth and account for >10% of total terrestrial carbon input to the ocean. As a result, mangroves provide a vital link between the terrestrial and oceanic carbon cycles and have been placed as a climate-change mitigation component on the international policy agenda. Despite their ecological and socio-economical importance, and the role they play in climate regulation, an increasing amount of evidence indicates that their geographic distribution is shifting in response to climate change, impacting human welfare, ecosystem functioning, and potentially also the dynamics of climate itself. I propose to study the GLObal-scale interactions between MAngrove forests and Climate (GLOMAC) by assessing, for the first time (1) the export, transport, and fate of carbon from mangrove forests in the ocean and its contribution to carbon sequestration in the global ocean and atmosphere and (2) the potential effect of climate change on the global distribution of mangroves and the role of different environmental factors therein. This ambitious goal will be achieved by (1) extending a novel global-ocean biogeochemistry model (ECCO-Darwin) with mangrove-ocean carbon fluxes derived from the first high-resolution (30 m) global mangrove canopy height dataset and (2) integrating mangrove habitat suitability estimates into a global-ocean dispersal model (ECCO-Dispersal). GLOMAC provides an important first step toward integrating coastal and global carbon cycles and will help improve understanding of the impact that global warming may have on the geographic distribution of mangroves and coastal ecosystem services. The resulting modelling tools can be refined upon availability of future data and wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Prevalidation of novel alternative pharma-/toxicological screening based on yeast expression technology' to be submitted under Fifth Framework.

assistant: **Abstract**

The project aims to the revalidation of a novel alternative pharma-/toxicologicalscreening on potassium channels involved in human diseases based on yeast expression. Ion channels conduct the nerve impulses and mediate the effects of many signal molecules. Potassium (K) channels are by far the most diverse group onion channels known and participate in a wide range of physiological responses. Inmost cells they are responsible for maintaining the resting potential. In excitable tissue currents mediated by K channels underlie the depolarisation of the action potential. Severe diseases connected to K channel dysfunction are ventriculartachycardia, hypertension, deafness and metabolic disorders. The yeast-based screening technology will provide a reliable system for pharmacy- /toxicological analysis and a bioassay for rapid identification of chemical and pharmaceutical compounds and has thus the potential to reduce the need for animal experimentation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'COMMERCIALIZATION OF AERIAL TOOLS APS (CAT)' (CAT) targeting Horizon Europe.

assistant: **Abstract**

Aerial Tools ApS (AT) is a Copenhagen based deep tech start-up. AT develops its own hardware and software intellectual property (IP) to produce a revolutionary Unmanned Aerial System (UAS) capable of unique inspection methodologies for remote and large infrastructure, with initial focus on maintenance inspection of solar parks. The aim is to improve aerial data acquisition in B2B commercial inspections and monitoring.During this project, we target to accelerate commercialization, boost our product and business development and attract private funding. We expect to achieve product market fit and validation of our inspection specification by performing pilot projects with potential customer. Finally, we expect to expand our team by attracting sales experts and automation engineers.One of our scope troughs the Women TechEU program is to attract and inspire other women to follow our passion into deep tech by getting in touch with women role models. We would like also to better understand gender equality policies and how to apply them within our organizations to promote women within a safe space that enable further possibilities for them. With the Women Leadership Programme (WLP), we expect to learn from experts in the same environment with similar challenges. Mentoring and coaching is something that we really value to improve our business plan, define the company strategy and reach commercialization before the end of the program. In addition, we are currently looking for investment.


**Keywords:** drone, renewable energy sector, inspection, monitoring, agriculture, LiDAR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Transcriptional repression by the dominant negative oncogene v-erba' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content Cancer is commonly linked to aberrant proliferation and a failure of the transformed cells to differentiate. Activated proto-oncogenes are thought to provide continuous proliferation signals that enhance the growth of transformed cells. Conversely, transformation can also be achieved by preventing transactivation of genes or gene network that regulate cell growth and/or differentiation. A prototypic example is the dominant negative oncogene, v-erbA, a mutated thyroid hormone receptor (T3R) variant encoded by the avian erythroblastosis virus (AEV). V-erbA is thought to antagonize T3R function through constitutive binding to T3-response elements and occlusion of the endogenous receptor and/or by actively repressing (silencing) transcription. Whether and how v-erbA represses natural genes within their chromosomal loci is largely obscure due to the lack of model systems. Recently, the Stunnenberg lab has been able to demonstrate that v-erbA silences expression of the chicken Carbonic Anhydrase II (CAII) gene through a novel v-erbA response element (VRE) located in an erythroid-specific enhancer. By using in vivo and in vitro approaches, I propose to use this model system to unravel the molecular mechanisms by which v-erbA and its cellular counterpart c-erbA/T3R silence transcription and to assess the role of putative co- repressor proteins in his process. This system affords a unique opportunity to investigate not only the molecular basis of erythroleukemia but also the regulation of the targeted gene by wild type and mutated nuclear receptors. Training content (objective, benefit and expected impact) The Stunnenberg group is among the leading in the receptor field. This study will provide novel insight in how gene transcription is regulated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Proteomic optimization of methods for ancient skeletal elements' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Palaeoproteomics has the potential to resolve some of the big questions in palaeoanthropology and human evolution, as proteins have been found to preserve over long time periods in the archaeological record, and contain phylogenetically relevant information. However, as this is a relatively new field of research, method optimization and gaining further understanding of ancient proteomes is necessary, to gain robust and reliable results with minimal destruction to rare ancient fossils. To this end, PROMISE (PRoteomic Optimization of Methods for ancIent Skeletal Elements) aims to improve palaeoproteomic analyses by developing and thoroughly assessing methods for removing modern contamination from ancient specimens, releasing proteins from the mineral matrix of bones and teeth, and understanding the effect that postmortem microbial bioerosion has on ancient skeletal proteomes. Finally, these optimised methods will be applied to study Middle and Late Pleistocene Levantine hominins. The Levant is essential for understanding human migration out of Africa, as well as interactions between different contemporaneous hominin populations, but is a challenging area of study for ancient DNA, warranting further palaeoproteomic method development. PROMISE will advance methods for the entire field of palaeoproteomics, as well as the study of human evolution. PROMISE will be conducted in a dynamic international research environment, providing the fellow with essential skills setting them up for a successful future career as a researcher in archaeological science.


**Keywords:** Human evolution, palaeoanthropology, palaeoproteomics, archaeological science
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'GPS/Water vapour experiment for regional operational network trials.' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

It has recently been demonstrated that signals from the Global Positioning System (GPS) of navigation satellites can be used (in a supplementary role to their positioning and navigation function) as a remote sensing tool to estimate the integrated precipitable water vapour (IPWV) content of the atmosphere ('GPS meteorology'), potentially with sub-millimetre accuracy and 30 minute temporal resolution on an all-weather, world-wide basis. Such data would be of considerable benefit to both climate studies and weather forecasting. This proposal will create links with the user meteorological and climatological communities in order that the EO data obtained can be fully utilised. The techniques of GPS data processing will be examined with the aim of providing an optimum, automatic system for the routine retrieval of IPWV. The validation and calibration phase of the technique will involve the collaboration of several research centres and the use of Water Vapour Radiometer (WVR) measurements. The radiometer instrumentation hardware and software will also be examined within the scope of this proposal to provide the most accurate estimates of IPWV. More specifically, the proposals main objectives are to: - Validate the accuracy and temporal resolution of GPS meterology, by comparison with ground-based water vapour radiometry (WVR), space-based radiometry (SSM/I) and radiosonde profiles, - To assess the feasibility of near real-time, automatic estimation of IPWV from GPS to an accuracy of 1mm, - To compute a post-processed data set of GPS IPWV estimates from a European sub-set of established permanent GPS monitoring stations (part of the International GPS Service (IGS) for Geodynamics network), for climate modelling studies and, - To investigate the possibility of obtaining a more