RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Synaptic functions of integrin-mediated cell adhesion in physiological conditions and autism-related abnormalities in mice' (SYNAMPADHESION) under Seventh Framework.

assistant: **Objectives**

Brain function critically depends on how neurons communicate with each others at specialized contact sites, the synapses. Cell adhesion molecules (CAMs) are key synaptic proteins that provide the molecular framework for organizing structural and functional aspects of synaptic connections. However, little is known about the underlying molecular mechanisms. We do not know how CAMs dynamically regulate synaptic strength in response to trans-synaptic interactions and how alterations in the function of some CAMs lead to neurodevelopmental disorders.We will investigate how the CAMs integrins, present on the postsynaptic side of excitatory synapses, control synaptic efficacy by regulating the properties of glutamate receptors in response to extracellular ligand binding, and how autism-related abnormalities in mice arise from dysfunctions in synaptic integrins. To this end, we will use a multidisciplinary approach to investigate brain function at the molecular, synaptic and behavioral level: we will employ STORM microscopy to examine the physiological relevance of integrin interactions for the submicroscopic organization of synapses, we will use integrin KO mice and viral injections to manipulate expression and activity of integrins in specific neurons, we will investigate synaptic function by electrophysiology in ex vivo brain slices and we will perform behavioral studies in live animals. Findings at all levels will be tightly correlated to understand how alterations in the nonlinear relationship between molecules, synapses and networks translate into behavioral impairments.The applicant has an internationally recognized broad expertise in synaptic physiology and cell adhesion, acquired while at UCL (UK) in the laboratory of Dr. Goda, who has now relocated her research group t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The EuroSIDA Network 2005-2009. Clinical and virological outcome of patients with HIV under care in Europe', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

There are currently over 1½ mill people in Europe with HIV. In recent years, the epidemic has intensified in the eastern region. The prevalence of HIV will continue to increase. There are significant problems with management of this public health crisis. Available antiretroviral therapy (ART) has several limitations: unable to eradicate HIV and hence required life long, resistance, adverse effects and adherence. Access to ART varies across Europe. A large proportion of the infected persons are co-infected with chronic viral infections (Hepatitis B and C viruses), which adversely affect their prognosis. Tuberculosis will become a major issue in Eastern Europe if access to ART does not improve. Most clinical research has studied the B subtype of HIV, but the non-B subtype is increasing in prevalence.A concerted action to study the clinical implication of these issues and provide a continued surveillance mechanism for detection of emerging problems on a European level is of critical importance. The primary objective of the study is to prospectively study demographic, clinical, therapeutic, virological and laboratory data from persons infected with HIV in Europe to determine the long-term virological, immunological and clinical outcome. A total of 16,100 patients from 90 centres in 33 European countries? 1/4 from the eastern region - will be followed. New patients will be recruited to ensure all regions of Europe are represented. By November 2009 a total of 83.000 prospective PYFU will have been collected. A central plasma repository will be used to extend studies of the viral epidemiology of HIV, measuring levels of ART drugs, and characterise hepatitis B and C viruses. Control programmes are implemented to ensure quality of the study.The study group in the EuroSIDA 2005-2
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ASTronomy EuROpean Infrared Detection' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Large infrared (IR) imagers in the NIR to VLWIR wavelength ranges are critical requirements for Earth observation, and Science and Astronomy missions. They provide information not available in the visible wavelength range like, for example, object temperature or chemical composition. The technology available in Europe today allows for detectors with around 1 Mega pixel to be manufactured. It is not able to produce the 4 Megapixel detectors necessary for future missions.Europe needs to become non-dependent for the procurement of these types of detectors.It is the goal of ASTEROID to develop the technology that will make Europe non-dependent for large IR detectors. The technology to be developed is based on HgCdTe detection layers grown on CdZnTe substrates and on large dimensions Si Read Out Integrated Circuits (ROIC). By adjusting its composition, the use of HgCdTe detection layers makes it possible to address all the wavelengths required, from visible to VLWIR wavelengths.ASTEROID will use the contributions from 6 partners in 5 different fields to develop the building blocks for large IR detectors:• ROIC processing: EVG and Sofradir• HgCdTe and CdZnTe processing: CEA-LETI and Sofradir• Hybridization of the ROIC and detection layers: Sofradir• Thermo-Mechanical Modeling: ADDL• Electro-optic and connectivity characterization: IFAE and CEA-IRFU


**Keywords:** Infrared imaging, science application, Earth observation, defence, Mercury Cadmium Telluride, Focal Plane Array, Cooled detector, Megapixel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'INtegrating Functional Assessment measures for Neonatal Safeguard' (INFANS).

assistant: **Innovation**

INFANS will train 15 ESRs with background from basic to clinical sciences in multiple aspects of neonatal brain monitoring. The need for a coordinated research training programme in neonatal brain monitoring arises from i) the severe shortage of clinically viable means to high quality monitor the brain function in infancy, crucial to prevent later life neurological, cognitive and motor impairment and ii) the lack of well-educated PhDs in this field. Through their individual research projects, encompassing technological innovation, industrial development, clinical validation, identification of neonatal healthcare needs, the INFANS ESRs will develop a novel platform for high quality, clinically-viable EEG-NIRS monitoring accessible worldwide. Excellent science, industrial leadership and societal challenge are merged in INFANS: 6 academic and 4 non-academic partner from 6 EU countries, among which leading universities, industries, clinical institutions, share complementary expertise and facilities to provide international, interdisciplinary and intersectoral research training and mobility that will complement local doctoral training. Well-targeted visits and secondments, soft skills and dynamic training activities, an Open Science strategy, extensive involvement of ESRs in the network events organization, extensive contacts with other research, training and industrial European networks, dissemination activities and the award of Double doctoral degrees are further assets of INFANS. The ESRs will learn to transform a scientific/technological challenge into a product of socio-economic relevance, as the INFANS functional neuro-monitoring system will reduce the number of children with neurological, cognitive or motor dysfunctions associated with brain injuries at birth. The INF
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'HYdrogen Public Opinion and accePtance', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

HYPOP aims to raise public awareness and trust towards hydrogen technologies and their systemic benefits, through: a) the preparation of guidelines and good practices that will help to define more effectively how citizens, consumers/end-users and stakeholders can be involved in the implementation of H2 technologies. b) the creation of a web platform collecting communication material, mainly videos, on new hydrogen technologies, developed according to the early findings of the public engagement activities.HYPOP is led by ENVI, an innovation accelerator for business with 20 years’ experience in the hydrogen sector.  HYPOP is represented by a well-balanced Consortium representing 6 Countries: National Hydrogen Clusters (IT, B, PL, BG), three Research Organisations (IR, ES), an Agency for the Promotion of European Research (IT).Four guidelines will be developed:  one more public oriented that will report on best practices to involve citizens, the other 3 collecting the results coming from the involvement of stakeholders’ groups (First Responders, Permitting Authorities, Certification Body).  HYPOP will also contribute to the definition of indicators to be used for Social Life Cycle Assessment of hydrogen technologies, and for this will focus on 2 applications: residential and mobility, which will enter into the daily life of people.  HYPOP will also be connected with some ongoing H2 projects characterised by demonstration activities in public spaces. Some of them have already been identified, i.e., Everywh2ere, Reflex, H2Ports, REMOTE: they are well known to the consortium partners and have faced some barriers often due to a lack of specific reference cases for the authorities called upon to grant safety and other permissions for the installation or use of the demonstrators
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Controlled processing for ceramic pastes components' (1994-1998) under Fourth Framework.

assistant: **Objectives**

In Europe the preparation of ceramic pastes is facing increasing economical and ecological problems due to the nature of used raw materials and to the treatment techniques. For trying to compose homogeneous lots with the required specifications, differential crushing and grinding operations followed by screening are a frequently used treatment. Hand cobbing, flotation in mechanical cells and magnetic separation are also adopted alternative processes, as well as, systematic controlled blending. Cut the peculiar environment imposed upon the functioning in preparation of ceramic components requires the utilisation of flexible cleaning/concentrating processes with an inserted reliable real time control where the set points adjustment should tolerate a wide variation of input and output conditions. The flotation process carried out in columns associated or not with mechanical cells is very adequate for separating quartz from feldspar, for cleaning pegmatites and also kaolinitic sands or clays, when treating fine size material. Flotation process consents very wide range of work conditions. Simultaneously, can be adapted to diverse outputs when controlled by a neuro fuzzy system. Such a combination (flotation plus neuro fuzzy control) would lead to positive industrial benefits. The column flotation process associated or not with mechanical flotation controlled on line by a neuro fuzzy system to be developed in this project will consist of a new mineral processing methodology for treating paste components. The final result will be the prototype of a mobile and compact pilot plant, which can be installed in the industrial plants to disclose the adequate industrial treatment policy for different types of input material and various output specifications. It is expected that, after
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dna replication in hyperthermophilic archaea' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content The recent genome sequences of several species of archaea indicate the presence of a eukaryotic-type replication 'machinery' in this third domain of life. However, our knowledge about the details of DNA replication in hyperthermophilic archaea is currently limited to the identification of a few putative replication proteins in the genome sequences available, and consequently we propose to initiate a systematic and broad study on mechanistic details of DNA replication in these extremophiles. Using biochemical and molecular biological means, we wish to investigate and identify previously unidentified archaeal replication factors. Their identification should be informative to further our understanding of DNA replication also in eukaryotic systems. We also might be able to identify unique proteins of commercial value that could be used to improve the processivity or fidelity of thermostable DNA polymerases routinely used in PCR applications. Using the plasmid isolated in Dr. Forterre's research group fromPyrococcus abyssii, in vitro assay(s) for hypertherrnophilic primase activity will be established. A yeast two-hybrid system will be used to extensively screen for proteins interacting with the known components of an archaeal replication fork. In addition, in collaboration with Genescope (French National Sequencing center), we will search for additional DNA replication factors in the genome sequence of Pyrococcus abyssii . Training content (objective, benefit and expected impact)  The host laboratory is an ideal place for the proposed experiments due to the availability of the highly specialised equipment necessary for cultivation of Pyrococcus species as well as the presence of several scientists with the deep knowledge and interest on DNA r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Two-dimensional liquid cell dielectric microscopy' under Horizon 2020.

assistant: **Concept**

Understanding molecular organization and dynamics which are governed by electrostatic and electrodynamics interactions on the nanoscale requires the measurement of dielectric polarization at the molecular level. Yet, this has remained a formidable challenge because standard dielectric spectroscopy is limited to the micrometer scale that is achieved by using microfabricated electrodes at low frequencies and optical approaches at high frequencies. At the same time, despite the advances in atomistic calculations, theorists struggle to predict dielectric polarization when the system approaches molecular sizes. During the last years I pioneered the development of scanning dielectric microscopy, measuring the dielectric constants of nano-objects as small as tens of nanometers in size - a resolution unparalleled world-wide. In the next five years, I will push the boundaries of the technique and probe the polarizability of liquids and biological macromolecules under two-dimensional (2D) confinement by implementing novel experimental and theoretical approaches. By engineering 2D liquid cells with controlled properties by van der Waals assembly, I will probe polarization and thermodynamic properties of nanoconfined molecular liquids for the first time on the molecular scale with fundamental implications for physical and life sciences. It will provide the experimental data to validate first-principles predictions and mean-field computational methods on which the study of condensed/soft matter and molecular biology is based. The proposal will exploit my current lead to access a key physical property of matter that has remained unknown so far, enabling a wealth of new science in a vast range of research fields, from physical sciences to chemistry and biology, and facilitating the de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Targeted Greatwall Kinase Blockade Offers A Novel Strategy for Chemoprevention' to be submitted under Seventh Framework.

assistant: **Abstract**

The progression of cells through mitosis is tightly regulated to ensure the integrity of chromosomal transmission and cell division. The proper orchestration of mitotic progression is controlled by the balanced activity of mitotic kinases and counteracting phosphatases. Misregulation of these controls can be detrimental causing loss of entire chromosomes and aneuploidy. Considering that mitotic kinases are only expressed in actively dividing cells, targeting these kinases for cancer management is highly desirable. To this end, we are validating the mitotic kinase Greatwall Kinase (Greatwall) as a target for cancer therapy. Initial studies show that siRNA knockdown of Greatwall leads to rapid cell death in a number of transformed cell lines. Surprisingly, we found that untransformed RPE cells with low Greatwall protein and mRNA levels remained unaffected after Greatwall knock down. Moreover, Greatwall levels fluctuate dramatically among different cancer cell lines and are generally low in non-transformed tissues. Seminal studies using Xenopus egg extracts and drosophila larvae show that Greatwall has an important role in the cell cycle control of rapidly dividing embryonic cells and it is possible that some tumor cells have reverted back to this state of dependency on Greatwall. This makes Greatwall even more promising as an anti-cancer agent as its activity is dispensable in somatic cells but critical to the survival and proliferation of cancer cells. In light of these findings, I aim to pursue target validation studies with Greatwall, elucidate synergistic effects using known mitotic kinase inhibitors, and work closely with a team of medicinal chemists to characterize novel small-molecule Greatwall modulators. Nonspecific interactions between known mitotic kinase inhib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding the new oxidative paradigm of biomass waste upcycling' (LyticPol), addressing dissemination and exploitation.

assistant: **Impact**

As the EU is committed to becoming the world’s first climate-neutral continent, fossil fuels need to be replaced by sustainable alternatives. A potential alternative is the upcycling of lignocellulosic biomass to biofuels. However, the cost-efficient generation of biofuel from cellulose is considerably hindered by the recalcitrance of the cellulose biopolymer. In 2010, the discovery of a new family of copper-dependent metalloenzymes called lytic polysaccharide monooxygenases (LPMOs) spurred great hopes as LPMOs were shown to significantly boost the degradation of cellulose and other polysaccharides.Today, eight families of LPMOs have been classified with remarkably diverse substrate specificities and regioselectivities. Furthermore, the metal active sites are in rather different surroundings. Despite combined efforts from experimental and theoretical sides, the reaction mechanism of LPMOs has remained elusive. The here proposed “LyticPol” project suggests that previous theoretical studies lacked general conclusions because they (i) considered too few LPMO families and (ii) employed insufficient theoretical methods for the enzyme environment.The “LyticPol” project aims at elucidating the reaction mechanism of LPMOs, by using a novel theoretical method on a large set of representative LPMO structures. From knowing the mechanism, the reaction conditions of LPMOs can be fine-tuned and the full industrial potential can be reached. This is expected to have substantial economic and social impact. Hence, the results of the “LyticPol” project will be communicated not only to scientific experts but also to the general public. The project will be carried out by Dr. Erna K. Wieduwilt (EKW) under the supervision of Prof. Erik D. Hedegård at the University of Southern Denmark. The pr