RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LARGE AREA FLUIDIC WINDOWS' (LaWin).

assistant: **Concept**

An important target of Europe 2020 is climate change and energy sustainability. To reach the ambitious aims, it is necessary to improve the energy performance of buildings in operation. Embodied energy in materials presents a high percentage of the energy spent in the whole life cycle of a building, so new materials are needed. Therefore we will develop within this project a novel material solution for ultra-efficient solar energy harvesting and heat exchange through an active building envelope. We thereby address the two technical applications of windows and facades, into which we will implement LARGE AREA FLUIDIC WINDOWS (LaWin). LaWin represents the vision of large-area microfluidic windows and facade elements which are based on four types of new materials: low-cost thin and strong cover glasses, microstructured rolled glasses of architectural quality, a glass-glass compound comprising microfluidic channels and a heat storage liquid designed for transparency and/or active functionality in facade and window implementation. LaWin devices will be designed to build on existing platforms and geometries used in triple glazing and facade elements to enable rapid market access and acceptance.Expected impacts:- Reduction of embodied energy and CO2 to 0 for window surfaces after four months of using (possible because of using regenerative energy with windows for climatisation of buildings, high insulation)- Reduction of at least 123 000 t CO2 per year for heating (goal: at least 2% of window furnaces in Europe)- Improving thermal insulation figures for window surfaces by at least 20%- Reduction of total costs-Purchase price is higher, but running costs are really low - Demonstration of at least a 10% reduction of the energy spent during the whole life cycle of a building;- str
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CogKnow: Helping people with mild dementia navigate their day' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The challenging aim of our three-year STREP proposal is to breakthrough with research that addresses the needs of those with dementia, particularly those with mild dementia in Europe. At about 2% of the elderly population, this comes to around 1,900,000 people. In order to achieve our aim, this means helping people navigate through their day. This entails cognitive reinforcement and may be expressed as the social objectives of our research for the needs of people with dementia, helping people to remember, maintain social contact, perform daily life activities and enhance their feelings of safety.There are few studies where people with dementia themselves describe their needs, but those carried out indicate the most frequently identified unmet needs are in the areas of information (on treatment, care and support, appointments), memory problems, and communication and psychological distress. A key strength of our consortium lies in the strong participative involvement of world-class medical/clinical experts with significant track records in working closely with people with dementia, to relate these needs.Our core technological objective is to research and prototype a successful, near-to-market, portable, remotely-configurable, user-validated cognitive prosthetic device and associated services for people with mild dementia. The solution helps this group of people to navigate through their day, unobtrusively offering information and reassurance and allowing them to retain control over their daily life activities.That COGKNOW focuses on a solution that assists people with dementia to reinforce their daily life is fully in accord with Strategic Objective 2.5.11 on the development of innovative solutions for persons with cognitive disabilities, with a specifically stated aim to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mineral based poreus tiles' to be submitted under Fifth Framework.

assistant: **Abstract**

Waterworks argue for many years to take measures to:- Prevent- and combat drought,- Manage shortage of groundwater. Two third of the drought is caused by fast drain edge off rainwater. In build-on urban area's, no rainwater is able to enter the soil and the water is drained of to surface water. A new type of mineral based poraous tile has been invented, which allows (rain) water to pass thought. The tiles require research and development to optimize the adhesive agent in relation to porousness, strength and make it suitable for mass production. Moreover, a production machine must be researched and developed to produce series of mineral based poroustiles, i.e. in a series ready for all user groups. The production process will be a cold production unit" and will not have any environmental impact. When used on a large scale, the product will tremendously reduce the amount of water that will flow unused into sewer systems."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'New Catalytic Asymmetric Strategies for N-Heterocycle Synthesis' (CatHet) targeting Horizon 2020.

assistant: **Abstract**

Medicinal chemistry requires more efficient and diverse methods for the asymmetric synthesis of chiral scaffolds. Over 60% of the world’s top selling small molecule drug compounds are chiral and, of these, approximately 80% are marketed as single enantiomers. There is a compelling correlation between drug candidate “chiral complexity” and the likelihood of progression to the marketplace. Surprisingly, and despite the tremendous advances made in catalysis over the past several decades, the “chiral complexity” of drug discovery libraries has actually decreased, while, at the same time, for the reasons mentioned above, the “chiral complexity” of marketed drugs has increased. Since the mid-1990s, there has been a notable acceleration of this “complexity divergence”. Consequently, there is now an urgent need to provide efficient processes that directly access privileged chiral scaffolds. It is our philosophy that catalysis holds the key here and new processes should be based upon platforms that can exert control over both absolute and relative stereochemistry.  In this proposal we outline the development of a range of N-heteroannulation processes based upon the catalytic generation and trapping of unique or unusual classes of organometallic intermediate derived from transition metal insertion into C-C and C-N sigma-bonds. We will provide a variety of enabling methodologies and demonstrate applicability in flexible total syntheses of important natural product scaffolds. The processes proposed are synthetically flexible, operationally simple and amenable to asymmetric catalysis. Likely starting points, based upon preliminary results, will set the stage for the realisation of aspirational and transformative goals. Through the study of the organometallic intermediates involved h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Tasty and healthy gluten-free bakery products and pasta - improved products for wide consumer acceptance' in the context of a Seventh Framework call.

assistant: **Objectives**

Currently two per cent of European consumers are suffering from coeliac disease that demands a strict gluten-free diet. Gluten is part of all common cereals and therefore contained in basic foodstuffs like bakery products and pasta. The market for gluten-free products, which is predominately served by small and medium sized enterprises (SMEs), showed considerable growth in the last years. However, the consumer acceptance of respective products is still limited by their insufficient taste, texture and mouth-feeling. GlutenFree will enable SMEs to produce premium gluten-free bakery products and pasta well accepted by the consumer. This will allow the SMEs to participate in this profitable market sector and concurrently improve their competitiveness. The new products have the potential to generate extra annual turnover and additional employment at the SMEs involved. Society will also benefit because coeliac patients as well as healthy consumers will have access to a wide pattern of tasty gluten-free foods which will make the diet and life of coeliac disease patients easier. Multilateral cooperation between food producers, ingredient providers and research institutes will provide required research and development resources as well as scientific knowledge. Alternative ingredients, namely plant proteins and hydrocolloids, should be developed which are able to replace gluten and to form similar network structures in bakery products and pasta. The interaction of different components in the recipes during baking and pasta processing and their influence on the texture and flavour formation will be analysed in order to allow specifically improvements. Sensory improvement should be ensured by using proper raw materials, aromatic malts or sourdoughs. Evaluation of consumer preferenc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Application of Neural Network Based Models for Optmization of the Rolling Process' under Fourth Framework.

assistant: **Concept**

Great amount knowledge of the use of ANN's as well as other data handling methods is gained. Many such tools or methods are developed. Several models concerning rolling of the steel strips are created or developed. Data availability and quality seemed to be one of the most critical factors; delays and deficiencies caused problems, especially in surface quality task.The steel product manufacturers are under a growing pressure to improve the yield and quality of their products. To meet these challenges, highly advanced rolling systems are being applied to new and updated mills. However, there are many process steps where exact mathematical models do not exist and the process is affected by human behaviour of the operator. Mill presettings, for instance, are traditionally calculated using mathematical models. However, continuous recalculation of model parameter is necessary to adapt them to actual process events. The application of neural network based method is proposed to overcome these shortcomings. Due to their ability to learn, neural networks can find the structure within measured data. The networks provide an effective way of building adaptive and intelligent systems for industrial applications. They are used in combination with traditional mathematical models. In process monitoring, the use of a Self Organising Map (SOM) algorithm is a potential research approach. This neural network method is based on unsupervised learning. It creates a non linear mapping from a multi dimensional input space to a usually two dimensional surface. SOM is especially suitable in analysing and modelling complex processes, with many process parameters as well as input and output parameters, such as strip and plate rolling processes. Experiments and long term on line applications with di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Clinical assessment of PILA PHARMA’s TRPV1 antagonist, XEN-D0501, as a novel type of oral anti-diabetic agent'.

assistant: **Innovation**

The XEND project aims to take key steps towards establishing a transient receptor potential vanilloid (TRPV1) antagonist, XEN-D0501, as a novel oral treatment for Type 2 diabetes (T2D). Diabetes is a constantly growing global epidemic. According to recent estimation, 422 million people worldwide are affected by the disease with a prevalence rate of 8.3%, and 46.3% still remains undiagnosed.Due to high risks of complications and related problems from mismanagement, closely controlling the treatment of diabetes is a primary concern for physicians and patients alike. Most commonly, the first recommendation is to address poor dieting habits and lifestyle modifications. This is followed by the first-line treatment of Metformin, which is recommended as an oral anti-diabetes drug that is used to help control glycemic levels in patients with diabetes when lifestyle modifications alone are insufficient. Pila Pharma has identified key missing components in the treatment of T2D. Through the XEND project, we will validate and begin steps towards out-licencing the first TRPV1 antagonist that has potential to constitute the cornerstone of an innovative first in- class drug for T2D treatment.  The market potential of XEN-D0501,  lies in its capacity to fill the existing market niche for efficient and safe TRPV1 antagonists and offer a new treatment option with improved Quality of Life to the increasing number of T2D patients.Pila Pharma will use the SME Instrument (Phase 1 and 2) to prepare and conduct a full Phase 2 Clinical trial. Further, we will begin engaging potential partnerships to take the drug through Phase III trials and ultimately to market. The clinical uptake of XEN-D0501 in Europe will meet the clinical and socioeconomic needs associated with diabetes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Heritability of chronic neuropathic pain'.

assistant: **Innovation**

Chronic pain undermines the health and welfare of millions of EU citizens and carries enormous financial costs. Individual variability in the burden of pain has traditionally been attributed to psychosocial factors. However, new data indicate that there is an important heritable predisposition to pain, particularly to the development of chronic pain after neural injury (neuropathic pain). Pain susceptibility genes are intrinsically hard to detect in human lineages and populations. We propose the alternative approach of exploiting new rodent models of neuropathy to uncover pain susceptibility loci and associated neurobiological processes, using inbred mouse strains that show high versus low pain phenotype. Linkage analysis and positional cloning, together with expression arrays and a variety electrophysiological and neurochemical methods applied to primary sensory neurons, will be used to identify the biological causes of contrasting pain phenotype. The strategy is to identify genetic and cellular variables that co-vary with pain phenotype across strains. With mouse candidate genes in hand, identification of the human orthologs is feasible. We stress that our project does not aim to find genes that affect susceptibility to specific disease entities that may be painful. Rather, we focus on genes and processes that determine the amount of pain felt by an individual in the presence of a specific disease state or degree of tissue injury. That is, we will investigate pain susceptibility genes rather than disease susceptibility genes. Such genes, and the neural processes with which they are associated, are expected to affect pain intensity irrespective of the proximate cause of the neural damage: trauma, surgery, neoplasm, infection or disease. Results will facilitate the deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bioengineered autonomous cell-biomaterials devices for generating humanised micro-tissues for regenerative medicine' (ATLAS) under Horizon 2020.

assistant: **Objectives**

New generations of devices for tissue engineering (TE) should rationalize better the physical and biochemical cues operating in tandem during native regeneration, in particular at the scale/organizational-level of the stem cell niche. The understanding and the deconstruction of these factors (e.g. multiple cell types exchanging both paracrine and direct signals, structural and chemical arrangement of the extra-cellular matrix, mechanical signals…) should be then incorporated into the design of truly biomimetic biomaterials. ATLAS proposes rather unique toolboxes combining smart biomaterials and cells for the ground-breaking advances of engineering fully time-self-regulated complex 2D and 3D devices, able to adjust the cascade of processes leading to faster high-quality new tissue formation with minimum pre-processing of cells. Versatile biomaterials based on marine-origin macromolecules will be used, namely in the supramolecular assembly of instructive multilayers as nanostratified building-blocks for engineer such structures. The backbone of these biopolymers will be equipped with a variety of (bio)chemical elements permitting: post-processing chemistry and micro-patterning, specific/non-specific cell attachment, and cell-controlled degradation. Aiming at being applied in bone TE, ATLAS will integrate cells from different units of tissue physiology, namely bone and hematopoietic basic elements and consider the interactions between the immune and skeletal systems. These ingredients will permit to architect innovative films with high-level dialogue control with cells, but in particular sophisticated quasi-closed 3D capsules able to compartmentalise such components in a “globe-like” organization, providing local and long-range order for in vitro microtissue development an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'BluePharmTrain'.

assistant: **Objectives**

Marine sponges harbour extremely diverse populations of microbes, and are world record holders for the production of a plethora of bioactive molecules. Previous studies, however, aiming at the growth of sponges or their associated microbes for the production of bioactive compounds to supply biological material for clinical trials, have been largely unsuccessful.BLUEPHARMTRAIN is a multi-disciplinary alliance of 20 academic and industrial partners that will excel in research and training through integration of complementary expertise in cell biology, microbiology, natural product chemistry, genomics & transcriptomics (omics) and socio-economics. We will adopt cutting-edge omics technologies to give a new boost to the more traditional disciplines: microbial isolation, cell culture and natural product chemistry to go beyond the current scientific frontiers. For example, metagenomic and transcriptomic data will be applied to identify the metabolic potential and restrictions of -yet- uncultured microbes and will serve for the design of tailor-made cultivation conditions. In addition, heterologous expression of bioactive gene clusters and enzymes able to perform unusual modifications will serve as an alternative strategy to unlock the bioactive potential of sponges. Thus we aim to develop an extensive technology platform that is applicable for obtaining a wide variety of bioactive compounds from distinct sponges and their microbes.BLUEPHARMTRAIN will provide a complementary set of experimental and conceptual local and network-wide training modules and workshops to 15 young researchers. The recruited fellows will work towards personalized training plans to meet individual needs and interests, generating a critical mass of young researchers in the emerging field of blue biotech