RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Mucus-Penetrating Microbiota: Characterization, Mechanism and Therapeutic in Metabolic Disease'.

assistant: **Innovation**

Mucus-Penetrating Microbiota: Characterization, Mechanism and Therapeutic in Metabolic DiseaseHumanity is facing an epidemic of inter-related metabolic disorders, including obesity, insulin resistance, hyperglycemia, hyperlipidemia, and hepatic steatosis, that altogether have major impact on the promotion of cardiovascular diseases. The increasing incidence of these complex metabolic disorders and their highly morbid, chronic and costly downstream diseases threatens to overwhelm the world’s health care systems and economies, making it a top public health priority in dire need of investigation.The intestinal tract is inhabited by a large and diverse community of bacteria, collectively referred to as the intestinal microbiota. When stably maintained at an appropriately safe distance from the epithelial cell monolayer, the microbiota provides important benefits to its host. However, disturbance of the microbiota-host relationship, promoted by genetic or non-genetic factors, can alter intestinal homeostasis and drive chronic low-grade intestinal inflammation, ultimately leading to metabolic abnormalities. We previously reported that a ubiquitous class of food additives, emulsifiers, detrimentally impact the microbiota resulting in its encroachment into the mucus layer that associated with low-grade inflammation and development of metabolic disorders. The central goal of this proposal is to investigate the hypothesis that bacteria that penetrate the inner part of the mucus layer, referred as invaders, promote development of metabolic alterations. We herein propose to identify mucus-invaders, in preclinical models and clinical conditions, and investigate mechanisms by which they promote inflammatory and metabolic abnormalities. Furthermore, we propose to define original appro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Translating basic research findings in major human diseases' under Seventh Framework.

assistant: **Concept**

Improvement of human health requires translation of the basic research discoveries into practical applications for human disease, including biomarker identification, novel clinical tools, and medications. The scope of TranSMed is to support the development of a center of excellence in the EU target area of “translational research for major human diseases”, in the convergence region of Attica, Greece. The applicants will combine their expertise for the development of a facility for improvement of human health in the mission areas of obesity, metabolic syndrome and neurodegeneration. The principal aim of the group is to maintain and advance academic excellence, to enhance innovative research , and ultimately advance diagnosis and management of the above diseases. Participants have made substantial scientific contributions, and now are poised as a group to get to the next level and make a major impact on translational research. This will be achieved by unlocking their potential via the actions supported by REGPOT1, such as (i) upgrading the research capability by hiring experienced scientists and expansion of the equipment infrastructure (ii) integration in the ERA via strategic partnerships, including twinning, for transfer of knowledge from excellent EU centers, (iii) development of new lines of research including bidirectional communication with clinicians, and training in interdisciplinary approaches (iv) development of a platform for data mining and bioinformatics approaches. The above will be supported by networking activities, such as international workshops, to promote research collaborations with industrial partners. The latter will increase the visibility of the group and of the regional community. Ultimately, TranSMed can provide the basis for related projects t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Genetic control of cell diversification into neuronal subtypes' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Vertebrate development is orchestrated by the coordinated deployment of multiple and diverse programs of cell commitment and differentiation. One of the fundamental questions in this process is how a discrete number of transcriptional programs and extracellular cues combine to produce the enormous cellular complexity that characterizes vertebrate organisms. This research aims at uncovering the general principles of how cellular diversity is created in the sensory nervous system.We aim to determine: 1/ the transcriptional programs directing the commitment and differentiation of different types of sensory neurons and 2/ how, when and where different types of sensory neurons are committed by genetic tracing. The proposed research takes advantage of multidisciplinary approaches including model systems and methods such as rapid screening of gene function in the chick, a boundary cap neural stem cell culture system, and advanced mouse genetics for revealing gene function and for lineage tracing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Future of Earth is Possible Through Collaboration between Scientists from Different Fields' (NIGHT4FUTURE) under Horizon Europe.

assistant: **Objectives**

The NIGHT4FUTURE project aims at showing that the Earth's future is possible thanks to the constant collaboration of scientists from different fields. By implementing Researchers’ Night programme, we will show that although the climate situation of the Earth is very difficult, science gives hope for saving it. The slogan ""in science there is hope"" will be the main motto of the whole event. Its aim is to make young people see science as a source of strength, opportunity and hope for the future. During the event, we will show how every field of science (technical, humanities, natural, health science) can be a source of hope to save the planet. Topics will highlight the importance of the European Green Deal for Europe and its citizens. See how the super engineer of the future will be, listen to the green alarm for the Earth, trace trash in space, take part in workshops about climate change, explore the secrets of biodiversity.You will find out that scientists are ordinary people and their work is really fascinating. The NIGHT4FUTURE project is a continuation of projects from the last fifteen years, but it also presents many novelties. Module Researchers at schools, pre-events and post-events have been prepared enabling researchers and pupils to interact on societal challenges revealing the key role of research in addressing these challenges. Based on the experience of previous years we are able to modify the program and the way of organizing events in response to the changing situation in the world. Topics of individual Partners have been selected to be consistent with the overall message of the project. This year's project aims to strengthen the previous ones and shed light on new aspects of science. We want to teach young people that the work of scientists brings hope
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Miniature information display' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Purpose of this project is to carry out research leading to the development of a 1280 x 1024 (SXGA) silicon backplane anti-ferroelectric liquid crystal (AFLC) display device using analogue greyscale techniques. Two application areas for this technology are:- high resolution miniature personal information displays such as virtual reality headsets - projection engines for large area (e.g. 1 to 3 metre diagonal) high resolution information displaysThe AFLC silicon backplane device with analogue greyscale has a number of potential advantages over alternative technologies:- Significantly lower mass and volume than cathode ray tubes (CRTs)- Brighter than monochrome electroluminescent displays, reflective so full colour can be obtained- Potentially lower cost and more reliable than Texas Instrument's Digital Light Processing Device- Estimated display addressing data rates 225 Mbits/s for analogue grey scale AFLC compared with 3.6 Gbits/s for an equivalent FLC device using temporal dither, under similar conditions- Higher aperture ratio than conventional transmissive polysilicon displays because bus lines and thin film transistors (TFTs) are buried under the reflective electrode- Higher resolution than conventional miniature LCDs using red, green and blue colour filters, because sequential colour provides multicolour single pixels- The AC driving of AFLC displays removes the need for a DC compensating frame used with FLCsPotential Areas of InnovationThe most innovative aspect of the project is in the use of AFLC materials to obtain analogue greyscale in a miniature silicon backplane device has not been reported by any group world-wide. Other areas of innovation include novel techniques to reduce the amount of light falling on to the CMOS circuitry, and reducing its sensitivity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Vibrational Spectroscopy for Molecular Crystals via Quantum-Mechanical Embedding Methods' in the context of a Horizon 2020 call.

assistant: **Objectives**

By this project, the routine calculation of anharmonic vibrational spectra and properties for practically relevant molecular crystals will be enabled via the usage of a quantum-mechanical (QM:QM) embedding approach. All monomers and relevant dimers are treated with a high-level method, while the fully periodic system is considered at a lower level. Highly accurate vibrational spectra can be obtained for small molecular systems with benchmark CCSD(T) utilizing second-order vibrational perturbation theory (VPT2) only with a computational cost prohibitive for routine applications involving larger systems. Therefore, the applicant will create a diverse benchmark set of monomers and molecular dimers covering a wide range of intermolecular interactions and subsequently benchmark the performance of various dispersion-inclusive density functional approximations (DFA) against CCSD(T) for vibrational properties calculated with VPT2, independent Morse oscillators, and the harmonic approximation.  Next, the QM:QM embedding approach for molecular crystals will be extended from available gradients to the calculation of harmonic vibrational spectra, which will already enable the usage of hybrid DFAs at a cost comparable to the generalized-gradient approximation. Subsequently, VPT2 calculations for monomers and dimers will be incorporated in the embedding scheme and the accuracy of the so obtained anharmonic vibrational spectra will be assessed for a variety of molecular crystals using promising DFAs identified during the first stage of the project. This methodology will be computationally affordable for practically relevant molecular crystals and is expected to aid peak assignments and interpretation of low-frequency THz spectra—used for instance for the detection of explosives. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Autonomous Cable assembly Enabler', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Cables are at the heart of electronic equipment that serves the medical, marine, aerospace, communications and automotive industries. The assembly of electrical cables is primarily based on human workmanship - however, manual assembly of cables is a delicate art that increases product cost, reduces quality as well as increases supply chain lines and cost. As a means to increase profitability, cable manufacturers from Europe have relocated their production facilities to low cost labour regions like North Africa, Mexico and China. Because of technological advances and statutory regulations as defined by IPC/WHMA-A-620 standards, it no longer viable to continue with manual assembly. There is an imminent need to develop machines that allow to automate the assembly to meet the standards requirements.As Frisimos, we have developed a evolutionary automated robotic assembly machines that will disrupt the electric cable assembly industry. The project idea is composed of three modules that can work as standalone machines or together forming a process line. The Layer Removal machine that enables cutting of metal with almost no heat, and to separately cut each layer with precise profile, is based on Laser ablation process, which uses specific wavelength and additional parameters. The Wire Sort machine that allows sorting cable wires according to their color or lettering, is based on a machine vision based algorithm. The Wire soldering machine welds the cable by laser, using a laser beam, which allows controlling the soldered spot size and the power, so creating the most optimal soldering. We will specifically concentrate on the automotive and communications market segments. The targeted market potential for our solution will grow from €12.29b in 2017 to €19b by 2022. We anticipate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Modelling high resolution spectra of galaxies with variable chemical abundances ratios'.

assistant: **Concept**

One of the most exciting recent developments in astrophysics has been the observation by large international consortia of hundreds of thousands of high-resolution spectra of galaxies in the local and distant Universe. The interpretation of these spectra in terms of stellar ages and metallicities is the key to reconstructing the star formation and chemical enrichment histories of the Universe.So far, however, such interpretations have been hampered by the fact that current models rely on spectral libraries of observed stars in the Milky Way and Magellanic Clouds, which have solar metal-abundance ratios at high metallicities. In contrast, the spectra of external galaxies appear to often be dominated by stars with non-solar metal abundance ratios (e.g., super solar alpha/Fe for massive galaxies). Until now, therefore, no spectral evolution model could help us fully exploit the wealth of information on chemical enrichment that is encoded in galaxy spectra. Only a few attempts were made to take into account the dependence of some spectral features on metal-abundance ratios.During my PhD thesis, I computed a comprehensive grid of high-resolution stellar spectra for non-solar mixtures of light elements at different metallicities. In collaboration with stellar evolution experts, we have assembled a grid of stellar evolutionary tracks for the same set of element mixtures. I plan to combine my spectral library with these evolutionary tracks to obtain the first fully consistent population synthesis models allowing the spectral interpretation of star clusters and galaxies in a wide range of chemical compositions.I will exploit this extremely powerful tool to quantify the effects of changes in abundance ratios on standard diagnostics of age and metallicity in galaxy spectra. By appe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Versatile Easy installable Connector incorporating new Technologies for accelerated fiber Optic network Roll outs in Europe' (VECTOR).

assistant: **Innovation**

VECTOR (Versatile Easy installable Connector incorporating new Technologies for accelerated fiber Optic network Roll outs in Europe) aims to develop and commercialize an innovative low-cost highly performing field installable connectivity system that will impact at a multi-million-euro scale the capital expenditure (CAPEX) and the operation expenditure (OPEX) of telecom fiber broadband networks and that will facilitate the achievement of the European 2020 objectives for broadband connectivity.The VECTOR connectivity system will comprise a ferrule-less connector granting ultra-high optical performance and a fully automated installation tool allowing for field installation by a general-skill technician.Disruptive fibre-handling techniques based on heat-shrinkable materials, advanced nano-textiles, and plasma-shaping will be developed and incorporated in the installation tool to ensure reliability, whereas high-tech gels and micro-mechanical alignment systems will be included in the connector to yield superior optical performance. Finally, micro-fabrication and replication techniques will be propose to ensure ease of volume production at low price. The use of connectors instead of permanent splices will grant flexible reconfigurability of the network.<br/>Overall, VECTOR aims to outperform the state-of the-art of ferrule-based connectors by optical performance, flexibility, reliability and cost. This will ultimately break the current paradigm of ferrule-based optical connectivity requiring extensive pre-engineering and highly specialized manpower for field deployment.In order to succeed in this ambitious goal, we created a consortium comprising the full portfolio of required technical knowledge, as well as the critical mass necessary to turn our connectivity system into a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Creating an electron-positron plasma in a laboratory magnetosphere' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The visible Universe is predominantly in the plasma state. On Earth, plasmas are less common, but they find many applications in industry and are also studied with the goal of providing an abundant energy source for mankind through fusion energy. The behaviour of plasmas studied thus far, in particular those that are magnetized, is very complex. The complexity manifests itself first and foremost as a host of different wave types, many of which are generically unstable and evolve into turbulence or violent instabilities. This complexity and the instability of these waves stems to a large degree from effects that can be traced back to the difference in mass between the positive and negative species, the ions and the electrons.In contrast to conventional ion-electron plasmas, electron-positron (pair) plasmas consist of equal-mass charged particles. This symmetry results in unique behaviour of the pair plasmas, a topic that has been intensively studied theoretically and numerically for decades but experimental studies are only just starting. These studies are not only driven by curiosity: Strongly magnetized electron-positron plasmas are believed to exist ubiquitously in pulsar magnetospheres and active galaxies in the Universe, and the entire Universe is believed to have been a matter-antimatter symmetric plasma in its earliest epochs after the Big Bang.We propose here to create and study the first long-lived and confined pair plasmas on Earth. This is now possible by combining novel techniques in plasma and beam physics. We will develop a levitated dipole confinement device and will fill it with readily available electrons and low-energy positrons from the world-leading steady-state positron source.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Prostate disorders : procurement of biomarkers and pharmaceuticals' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

we will procure biomarkers and pharmaceuticals for prostate disorders. About 1 in 4 men over 55 have lower urinary tract symptoms due to benign prostatic hyperplasia, and 1 in 10 a lifetime risk of prostate cancer. Prostate disorders are a growing major socio-economic challenge because of our ageing population. We are clinicians, scientists and industrialists with complementary expertise and proven ability to collaborate. We will use prostate samples that are clinically well-defined and proprietary (DATAS) and established (suppression subtractive hybridisation, proteomics) approaches to identify changes in gene expression. We will show in clinical and model systems that these changes are important for prostate pathogenesis, and develop diagnostic/prognostics biomarkers and therapeutics for the painful and debilitating disorders of the prostate.