RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Infrastructure co-operation network in area of combustion and solar energy'.

assistant: **Innovation**

Description:The main task is the running of the Infrastructure Co-operation Network to facilitate exchange of ideas and good practice amongst the members, improving and developing access to the facilities and dissemination to the community at large through the use of a Virtual Network/Internet. The technical objectives and work programmes are linked to specific study panels and can be defined as:Study Panel 1: High Temperature Characterisation and Materials.Comparison of techniques for characterising high temperature, suitability of new materials for instrumentation development, identification and transfer of good practice.Study panel 2: Requirements for Research and Development.Make proposals for future research and development in the area of combustion, solar energy and hybrid systems for the power, process and furnace technology sectors, examine and compare programmes, trends and directions of non EU countries and consider their impact in the European context.Study panel 3: Industrial Training.Performance of universities and their relevancy to energy intensive industry, analyse the use of the Internet for industrial training using for example Computer Aided Learning techniques, transfer of good practice and improved dissemination.Project Manager:Nicholas SyredCardiff School of EngineeringThe ParadeCardiffCFR24 3TAP.O. BOX 685United KingdomTel: +44-2920-874318Fax: +44-2920-874317E-Mail: SyredN@cardiff.ac.uk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Immunology of lymphatic filariasis' (1994-1998).

assistant: **Concept**

* To establish the relationship between immune response to filarial parasite antigens and the length of exposure to transmission.* To identify major antigens from the infective L3 stage of Brugia malayi, as defined by reactivity with human immune sera and T cells.* To identify the major antigens from the microfilarial (Mf) stage, and to test for antigenic variants of these antigens.Expected Outcome* An understanding of stage-specific immune responses in pathology and immunity.* Molecular data on sequence and polymorphism of Mf sheath antigens.* Sequence and profile of immune recognition of L3 antigens.The immunology of exposure to and infection with lymphatic filarial parasites, with respect to T cell subsets and stage-specific antigens, will be assessed. The first aspect will be the relationship between exposure to filarial transmission and the evolution of immunomodulated responses, evident in a strongly TH2 biased, TH1 down-regulated profile. Patients subject to lifelong transmission of filariasis will be compared with immigrants into the same area whose exposure is limited to only 4 or 8 years. The progression of the T cell subset bias, and the development of antigen-specific unresponsiveness seen in filariasis, will be monitored. An important question is whether this subset bias relates primarily to the adult stage, or whether other stages are similarly involved.Secondly, prominent antigens from L3 and Mf stages will be isolated and cloned for functional analyses. The importance of such antigens in mediating protection against disease can be directly assessed using sera and T cells from the study populations; their biological role in the host-parasite relationship may also be deduced from database sequence similarities and the opportunity to discover new antigens f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Natura 2000: a sociological study' (N2SOC).

assistant: **Concept**

The proposed Fellowship is designed to provide a promising post-doctoral sociologist specialising in the niche area of nature-society relations, the opportunity to pursue a period of training in the Nature-Society Research Group of the School of Geography at the University of Exeter in the UK. Under the supervision of an internationally renowned scholar in this field, and with further theoretical training, the Fellow would employ this 2 year period to develop and expand upon her highly commended PhD research into how Natura 2000 is experienced in Ireland. Through the addition of a new UK based case study and the re-visitation of Irish case studies, the Fellowship would allow comparative analysis with the UK experience and longitudinal analysis of the Irish situation from 2005 to 2011. The objectives of the research are threefold: (1) develop state-of-the-art sociological/geographic themes regarding nature-society relations, (2) to explore the socio-political dimensions of these findings and (3) to make recommendations for innovative models of nature conservation theory and practice, allowing the transfer of knowledge to other EU country contexts. The study will be multidisciplinary, drawing on insights from sociology and human geography and pulling these together with new thinking in ecology and natural resource management. The project is expected to advance the development of state-of-the-art nature-society theoretical frames within environmental sociology and human geography while contributing to the body of research literature regarding nature conservation conflicts and dilemmas. It will provide a grounded analysis of how Natura 2000 is experienced in two EU member states where nature conservation and rurality have very different socio-political connotations. Its pra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A European Collaboration to optimise research for the care of cancer patients in the last days of life', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The project aims to explore, share and collate existing knowledge and practice in each of the key themes identified within the work programme. It aims to reach consensus (based on current practice and available research evidence) on the optimum care to be delivered in the last days of life and gaps in the knowledge base. In addition, it aims to develop innovative ways of addressing gaps in knowledge with the specific aim of improving care for cancer patients in the last days of life. Clearly, such improvements would also impact positively on their informal carers and health professionals delivering the care. Importantly, it aims to do this systematically and collaboratively across Europe and beyond to integrate knowledge from a range of healthcare enviroments and cultures and to avoid duplication of resource and effort.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SOFT, the first camera-based colorectal cancer screening test to detect occult blood in faeces immediately and with no lab analysis.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

You don’t feel Colorectal Cancer starting, and when you do, it’s too late. This makes Colorectal Cancer the second most frequent malignant disease in Europe. Every year, 412 000 people are diagnosed with this condition, and 207 000 patients die of it . Yet, Colorectal Cancer is a highly treatable cancer if detected early: 9 out of 10 cases of Colorectal Cancer could be treated successfully if diagnosed at an early stage . Mass screening saves lives, but has low participation due to a cumbersome and expensive process.SOFT Medical has developed a home-use Colorectal Cancer screening device which is accurate, simple to use, cost effective and requires no sample shipment for laboratory interpretation. The Smart Optical Faecal Test (SOFT) leverages an optical instead of a chemical/biological test (which requires reagents and laboratory interpretation), providing accurate, specific and immediate results. The camera-based device is indeed capable of visually detecting asymptomatic Colorectal Cancer through the processing of the sample’s picture. This makes SOFT method simple and patient-friendly. With 90% success in treating early stage Colorectal Cancer (vs. 10% in late stages) patient’s acceptance and compliance with screening is key. The SOFT project addresses wide European and global challenges by providing a disruptive technology for earlier and more accurate Colorectal Cancer detection. The ambitious goal set by the Commission Communication on Action Against Cancer  is to reduce cancer incidence by 15% by 2020. SOFT will contribute to reaching this target, easing the patient participation to the test, and with that, increasing the Colorectal Cancer survival rates.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Compartmentalization and dynamics of Nuclear functions'.

assistant: **Innovation**

The eukaryotic genome is packaged into large-scale chromatin structures that occupy distinct domains in the nucleus and this organization is now seen as a key contributor to genome functions. Two key functions of the genome can take advantage of nuclear organization: regulated gene expression and the propagation of a stable genome. To understand these fundamental processes, we have chosen to use yeast as a model system that allows genetics, molecular biology and advanced live microscopy approaches to be combined. Budding yeast have been very powerful to demonstrate that gene position can play an active role in regulating gene expression. Distinct subcompartments dedicated to either gene silencing or activation of specific genes are positioned at the nuclear periphery. To gain insight into the mechanisms underlying this sub-compartmentalization, we will address three complementary issues: - What are the mechanisms involved in the establishment and maintenance of silent nuclear compartments? - How and why are some activated genes recruited to the nuclear periphery? - What are the relationships between repressive and activating nuclear compartments? Concerning the maintenance of genome integrity, recent advances in yeast highlight the importance of nuclear architecture. However, how nuclear organization influences the formation and processing of DNA lesions remain poorly understood. We will focus on two main questions: - How and where in the nucleus are double strand breaks recognized, processed, and repaired? - Where do breaks or gaps resulting from replicative stress at 'fragile sites' arise in the nucleus and how does nuclear organization influence their stability? We hope to gain a better understanding of the mechanisms presiding nuclear organization and its importance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project '11th european carbohydrate symposium' (1998-2002) under Fifth Framework.

assistant: **Objectives**

EUROCARB XI will take place at Faculae de Cadencies ad Universities de Lisboan from September 2-7, 2001.This Symposium is held on a non-profit making basis and is fully self-financing. The presentations will cover a variety of areas related to Glycoscience, focusing problems of strategic importance for Europe and dealing with topics such as therapeutic substances, development of vaccines, nutrition and health, paper and fibres biotechnology. The multidisciplinary contributions of the plenary and invited lecturers from Industry, Universities and Research Institutes will give the participants, including the European young researchers and the scientists from NIS and CEEC, the opportunity to understand how to put research into work. Approximately 600 participants are expected to attend the Meeting, which will be transmitted by web cast. We request funds to partially cover the attendance costs of 13 plenary and 54 invited speakers and to help with the participation of 25 young researchers and scientists from NIS and CEEC. Our request is to cover 100 %of the difference between the total costs and the income of the Meeting, which corresponds to 48 % of the total costs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Towards a stem cell therapy for stroke' (STEMSTROKE) under Sixth Framework.

assistant: **Objectives**

Stroke is a major cause of long-term disability in humans, but effective treatments are lacking. The StemStroke consortium comprises 5 highly qualified academic research teams and one SME which, together with excellent clinicians in the stroke field, will perform innovative research leading to the first preclinical protocol for application of stem cell therapy in stroke patients. Human neural stem cell (NSC) lines will be isolated from the foetal and adult brain, and from embryonic stem cells. Cellular and molecular mechanisms regulating the proliferation, migration, survival, and differentiation of the NSC lines after transplantation into the stroke-damaged rodent brain will be determined. The StemStroke will explore the morphological and functional integration of grafted and endogenously generated NSCs and their progeny in the stroke-damaged brain, and develop new in vivo imaging and behavioural tests, relevant for the human situation, for assessment of stem cell function and recovery of sensory, motor and cognitive deficits. Finally, StemStroke will optimize transplantation- and endogenous neurogenesis-based strategies and create an important preclinical protocol which can be rapidly translated into human trials. The teams contain top-level expertise in animal models of stroke and MRI-based in vivo imaging, stem cell, molecular, and cellular biology, molecular genetics, animal behaviour and psychology, translational research, and clinical cell therapy. Through the participating SME, commercial exploitation of the knowledge emerging from the project is ensured. The complementarity of expertise within the consortium, together with the intellectual and technological resources available from each partner, will ensure efficient and high-quality performance and feasibility
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Combining and Uniting Business Intelligence and Semantic Technologies' (CUBIST) under Seventh Framework.

assistant: **Objectives**

Constantly growing amounts of data, complicated and rapidly changing economic interactions, and an emerging trend of incorporating unstructured data into analytics, brings new challenges to Business Intelligence (BI). Contemporary solutions involve BI users dealing with increasingly complex analyses. According to a 2008 study, the complexity of BI tools is the biggest barrier for success of these systems. Moreover, classical BI solutions have, so far, neglected the meaning of data.Semantic Technologies (STs), deal with this meaning and are capable of dealing with both unstructured and structured data. Having the meaning of data in place, a user can be guided during his work with data. In particular, we foresee FCA (Formal Concept Analysis), which is a well known ST, to be a key element of new hybrid BI system. However, STs have, traditionally, operated on data sets a magnitude smaller than classical BI solutions. They also lack standard BI functionalities such as Online Analytical Processing queries, making it difficult to perform analysis over semantic data. On the other hand, 'understanding data' will improve classical methods in BI-CUBIST combines essential features of ST and BI. We envision a system with the following core features:* It supports federation of data from a variety of unstructured and structured sources,* The persistency layer is an Information Warehouse; having a BI enabled triple store in its center,* Semantic information is used to improve BI best practices,* CUBIST enables a user to perform BI operations over semantic data,* Semantic data warehouse is used to realize advance mining techniques known from, in particular FCA.* Novel ways of applying visual analytics in which meaningful diagrammatic representations of the data will be used for represen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Behaviour, perceptions, cognition, knowledge, organizations. Relational contracting approach to design of contractual forms when information is imprecise.' to be submitted under Horizon 2020.

assistant: **Abstract**

This project aims to provide the first analysis of relational contracting when the parties do not (initially) have precise information about the various courses of actions, and experiment them through the relationship. Examples include innovative activeties such as book publishing, research and development, technology adoption in developing countries, and drafting rules and laws in bureaucratic setting.We introduce in relational contracts framework imprecision about the prospects of actions. Imprecision is formulated as ‘ambiguity’ by building on recent developments in decision theoretic literature. The aim in this project is to explore how the interaction of imprecise perceptions about the consequences of actions and moral hazard introduce new conceptual and analytical issues and how such an interaction plays a role in shaping dynamic relational incentives. An understanding of these questions is relevant not only for motivating research and development, but also for diverse applications including technology adoption in developing countries, book publishing, as well as drafting new policies and rules of law.  In publishing an author will typically have some imprecise information about the new project as previous experience is only partly relevant for new venture, and possibly better information in writing the book than the publisher. Technology adoption in developing countries is similarly dynamic process of experimentation and learning via relationship. Local entrepreneurs have better yet imprecise ideas about new technologies and new practices than development agencies. In policy making and drafting new rules of laws, uncertainty about various acts can shape the optimal degree  of delegation implied by the moral hazard between politicians and between bureaucrats so th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Rational and Combinatorial Engineering of Antagonistic Angiopoietin Variants as Tools for Cancer Imaging and Therapy'.

assistant: **Innovation**

The dysregulation of cell signaling pathways that mediate proliferation, survival, and migration is an underlying cause of many cancers. Dysregulation and over-expression of the Tie2 tyrosine kinase receptor, in particular, correlates to a poor prognosis for many human tumors, making Tie2 an attractive target for therapeutic intervention.  Currently no FDA-approved therapeutics targeting the Tie2 receptor exist, and only a few candidate molecules are in early stage clinical trials. Moreover, development of Tie2-targeted molecular imaging agents for non-invasive visualization of Tie2 expression in vivo has been extremely limited compared to other cancer targets. Such imaging agents could help identify the best patient candidates for Tie2-targeted anti cancer therapies.Although ligand-based antagonists have opened up new research directions for generating new cancer biologics, limitations in ligand binding affinity, expression yield, and stability have prevented all but a few from advancing to clinical trials. The limited success of ligand-based antagonists motivates me to use modified Tie2-receptor agonists, i.e. angiopoietins, as a starting point from which to develop ligand-based antagonists. Angiopoietin antagonists will be created by introducing mutations into an angiopoietin that retains Tie2 binding but that prevents ligand multimerization and receptor dimerization and activation. Yeast-displayed angiopoietin mutant libraries will then be created and screened by high-throughput flow cytometric sorting to identify variants with increased expression and stability and affinity to Tie2.We will perform pre-clinical studies on the high affinity angiopoietin variants to determine their potential as in vivo molecular imaging agents and cancer therapeutics. In addition, we