RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Modular Big Data Applications for Holistic Energy Services in Buildings'.

assistant: **Innovation**

The decentralization of the energy system coupled with advancements on IoT, big data, AI and distributed computing are creating a new momentum for exploiting data-driven services to improve buildings energy efficiency. Despite a large number of buildings data hubs and vocabularies have become available, some barriers hamper the exploitation of that potential, such as the lack of interoperability among heterogeneous static (e.g.BIM), building automation and IoT dynamic data sources and ontologies, and the lack of interoperable big data architectures fully tailored to smart buildings. In that respect MATRYCS will i) deliver an open Reference Architecture for Smart Energy Efficient Buildings, which aligns BDVA SRIA, FIWARE architecture, SAREF, HAYSTACK, and BRICK schema vocabularies (among the many others), and enable B2B sovereignty preserving multi-party data exchange, while providing full interoperability of big data enablers with smart buildings standards and addressing privacy and cyber-security constraints ii) upscale a number of TRL 5-6 technology enablers, such as sovereignty-preserving DLT/off-chain data governance, big data pipeline orchestration, IoT/edge AI-based federated learning and visual analytics and deploy them within the TRL 7-8 MATRYCS workbench iii) deliver a TRL8 open modular big data cloud analytic toolbox as front-end for one-stop-shop analytics services development iv) validate such framework through the deployment of analytics services focusing on digital building twins, improved buildings operation, building infrastructure design, EU/national policy assessment for energy efficiency investments on 11 large scale pilots by different stakeholders (facility managers, ESCOs, financial institutions, construction companies, municipalities, electricity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'LEAVE NO ONE BEHIND: BOTTOM-UP ENERGY TRANSFORMATION OF LAST-MILE COMMUNITIES' (SWARM-E).

assistant: **Innovation**

SWARM-E is a trans- and multi-disciplinary approach for sustainable, affordable and modern energy access and well-being for Sub-Saharan Africa, aligned with the AU-EU Agenda 2063. SWARM-E consists of several layers: 1) an innovative renewable electricity infrastructure, the SWARM grid, a circular and cyber-smart network where end-users exchange electricity of their solar home systems and form the nodes of a smart grid which can dynamically grow to meet demand; 2) unlocking unutilised renewable energy for productive uses in the water energy food nexus – cold storage, water purification, water pumping and irrigation, carpentry; 3) transfer and decentralisation of Global North energy transformation innovations – decentralised hydrogen production for cleaner cooking, bi-directional charging of light electric vehicles (two- and three-wheelers) to transport goods and people. SWARM-E builds on network effects generated through the inclusion of localised economies with strong producer-consumer linkages embedded within larger systems of trade and exchange for the creation of bottom-up energy communities. SWARM-E will operate and replicate 5 pilots in Rwanda and Tanzania, under which 5 SWARM grids are installed, delivering 6.9 GWh of renewable electricity while generating income through the trading of electricity and avoiding the discard of 3,200 batteries; 5 water purification applications deliver 101.M L of clean water; 15 light electric vehicles deliver farmers’ produce, power mobile productive uses and cold storage, increasing the yields of 1,000 farmers and reducing the food losses of more than 5,000; 700 kg of H2 are blended with LPG for cleaner cooking, and more than 500 jobs for women and youth are created. The balanced participation of EU and AU private, public and civil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Islamic Law materialized: Arabic legal documents (8th to 15th century) (ILM)' (ILM) under Seventh Framework.

assistant: **Objectives**

The project examines edited and unedited Arabic legal documents from a new comparative perspective. Documents, immediate manifestations of legal practice, were instruments to assure subjective rights of persons for whom the copy had been issued. Most studies on early Islamic legal practice however focus on literary sources (notarial manuals, responsae, juridical treaties) and neglect documents mainly for two reasons: 1) cursive handwriting and technical language render their deciphering difficult; 2) the existing collections come from various provenances which hindered until now a synthetic analysis. This project inverses the focus with a new historical perspective: Thanks to its innovative full text database (CALD) that analyses documents by functional components and sequence-patterns, the project reveals relevant variations in structure and juridical clauses among many documents, in great detail and from multiple aspects. Even if existing studies on specimens from various regions establish a general conformity of these documents with Islamic law, the PI s analysis of the 14th-century Jerusalem corpus illustrated, for the first time, how  private  notarisation (of legal transactions) and court documents (with judicial elements) were used complementary to apply the complex rules of Islamic procedural law. The CALD-database facilitates comparing and deciphering legal documents. The research group will use this methodology with three under-examined corpuses from al-Andalus, Egypt and Palestine from the 13th to the 15th century, and compare these to other edited documents from Central Asia, Iran, Syria, Egypt and Muslim Spain (8th-15th centuries). This approach aims to a) develop a sophisticated typology of legal documents and their components, b) compare various notarial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'NeurescueTM: Computer- controlled aortic occlusion device for the treatment of cardiac arrest' under Horizon 2020.

assistant: **Concept**

With a worldwide incidence expected to increase from 9,23 million cases by 2020 to 10,89 million cases by 2030, Sudden Cardiac Arrests (SCA) episodes are today recognized as a public health problem leading to severe brain tissue damage with survival rates below 10%. Neurescue Aps (NEUR) proposes to address the SCA burden by bringing to light a game changing solution - NeurescueTM – capable of extending the critical time window necessary to bring a SCA patient back to normal heart function, and therefore holding the potential to radically improve the emergency assistance provided to SCA patients, allowing for 20- 40% of increase in the survival rate of SCA patients. Due to an algorithm-run sensor technology which enables a safe and accurate computer-controlled aortic occlusion, NeurescueTM is a portable medical device that, not only increases the blood perfusion pressure necessary for vital organs preservation (i.e. brain and heart), but also works in synergy with standard resuscitation procedures increasing their probability of success. NeurescueTM is the only device in the market that combines portability with the accuracy required for a safe medical intervention (i.e. aorta occlusion) to SCA patients both inside and outside the hospital premises. With a price-competitive technology and with an unrivalled value proposition, NEUR is in a strong position to build a profitable business. Building on the project activities, NeurescueTM the device is projected to be ready for commercial roll-out by 2021 with a predicted total aggregated revenue for the company of over €234M throughout the 5 years post- project. CAtALySt project aims to surpass the main market barriers associated with the market introduction of NeurescueTM, namely obtaining FDA clearance, gathering data for C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Generating mRNA-HNF4a-Lipid nanoparticles for curing pancreatic cancer-associated cachexia (CAC) in identified patients at risk' (CAC) targeting Horizon Europe.

assistant: **Abstract**

Cancer-associated cachexia (CAC) is a multifactorial syndrome causing significant morbidity and mortality in cancer patients and indicates a poor prognosis. Nearly 80% of cancer patients experience CAC, which directly accounts for almost 20% of all cancer deaths, mainly in patients with pancreatic adenocarcinoma (PDAC). Clinically, CAC manifests as weight loss and wasting of skeletal muscle mass. Thus, CAC patients experience reduced physical, emotional, and social well-being, leading to increased use of healthcare resources. The massive phenotypic manifestations point to a significant imbalance in the systemic metabolism of CAC patients. Unlike starvation, CAC cannot be reversed by standard nutritional interventions, and currently, there are no biomarkers for identifying patients at risk for CAC and no effective therapeutic modalities. With our ERC (#818943), we identified changes in liver metabolism during extra hepatic carcinogenesis. We now demonstrate that these metabolic changes occur early, precede CAC, and can be diagnosed by routine liver biochemical profile. We generated a biochemical liver score that can identify PDAC patients at risk for CAC, irrespective of disease stage at diagnosis. Furthermore, we find that these metabolic changes in the liver are mediated by early infiltrating immune cells that lead to HNF4a depletion in hepatocytes independent of liver metastasis. Importantly, we find that re-expressing HNF4a with Adeno Associated Virus (AAV8) preserves liver metabolism in PDAC mouse models and alleviates CAC. We hence hypothesize that generating liver-specific mRNA of HNF4a will be highly therapeutically beneficial for PDAC patients identified by our liver score to be at risk for CAC. In this PoC we will generate and test the efficiency of novel HNF4a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Closing waste water cycles for nutrient recovery' under Horizon 2020.

assistant: **Concept**

WalNUT aims to develop the necessary concepts and technological solutions to re-design the value and supply chains of nutrients from waste water and brine, while staying in line with the objectives of the EIP on Agrifood and Raw Materials. A wide range of technological processes (physico-chemical, electro-chemical, biological) will be validated in labscale. 5 pilot plants for the nutrient recovery from waste water and brine will be tailored by combining multiple process units selected from the pool of technologies studied at lab scale and from partners previous relevant projects. The pilot plants will target not only high nutrient recovery efficiencies but also minimisation of environmental impacts. Thorough quality assessment of the resulting products shall be made in order to establish a concrete view of their market positioning. The multicriteria evaluation of pilot plants performance as well as the use of LCA, LCC, sLCA, will lead to the efficient validation of the technologies reaching TRL 4-6. Also, the project aims to create and disseminate a new paradigm shift from waste water and brine treatment to resource recovery which is essential for EU to sustain industries and societies for the long-term. Public and scientific awareness of the project will be raised and all relevant stakeholders will be informed about the possible pathways for waste water and brine valorisation. The project will be implemented by a consortium composed of partners with varied and complimentary experience, qualifications, skills and perspectives including research institutes, technology providers and industrial partners involved in waste water management. The involvement of representatives covering the whole supply chain of waste water, brine and nutrient recovery will provide an excellent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Children's Palliative care Outcome Scale' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Person-centred care is a core health value of modern health care. The overarching aim of C-POS (Children's Palliative care Outcome Scale) is to develop and validate a person-centred outcome measure for children, young people (CYP) and their families affected by life-limiting & life-threatening conditions (LLLTC). International systematic reviews, and clinical guides have highlighted that currently none exists. This novel study will draw together a unique multidisciplinary collaboration to pioneer new methods, enabling engagement in outcome measurement by a population currently neglected in research. C-POS builds on an international program of work. The sequential mixed methods will collect substantive data through objectives to determine i) the primary concerns of CYP and their families affected by LLLTC & preferences to enable participation in ethical person-centred measurement (n=50); ii) view of clinicians and commissioners on optimal implementation methods (national Delphi study); iii) a systematic review of current data collection tools for CYP regardless of condition; iv) integration of objectives i-iii to develop a tool (C-POS) with face and content validity; v) cognitive interviews to determine interpretability (n=40); vi) longitudinal cohort of CYP and families to determine test-retest reliability, internal consistency, construct validity and responsiveness (n=151); vii) development of resources for routine implementation viii) translation and interpretation protocols for international adoption. C-POS is an ambitious study that, for the first time, will enable measurement of person-centred outcomes of care. This will be a turning point in the scientific study of a hitherto neglected group.


**Keywords:** Patient-centred outcomes, palliative care, paediatrics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'PreEclampsia diagnosis by Early Kidney Injury Detection' (PREKIND) under Horizon 2020.

assistant: **Objectives**

Health Challenge:PreEclampsia (PE) claims the lives of 75,000 women annually and the 6,000,000+ surviving mothers will have an increased risk of cardiovascular disease for the rest of their life. PE accounts for over 500,000 infant deaths worldwide every year1; and for the millions of babies that survive, they too will go on to have increased risk of a variety of health issues. PE is a syndrome that develops during pregnancy but presents no clinical symptoms during most of the pregnancy and is therefore currently complex to diagnose.  Business Challenge:With an annual spend of over 31Billion in direct costs in the developed world alone, the provision of antenatal care to pregnant women has a significant impact on health care budgets; dealing with the immediate consequences of PE form an important contribution to this cost. The Preelampsia foundation (http://www.preeclampsia.org/)  estimates the annual cost of PE is more than $7billion in the US.  InformBio Business Innovation:InformBio (IB) has licensed pioneering research by Dr.Vesna Garovic of the Mayo Clinic, USA. The technology has identified podocyte specific biomarkers in urine that indicate ongoing renal damage and which allow for a sub-clinical diagnosis for PE. The key biomarker, podocin, has demonstrated exceptional sensitivity and specificity and can diagnose the disease up to 3 months before clinical symptoms emerge3.  InformBio are currently working to develop flow cytometry and research use only (RUO) ELISA assays for the biomarker. InformBio’s ambition is to be the world leader in early pregnancy prognostic tests, offering the most innovative, cost effective solutions to predict pregnancy complications. Phase 1 proposal:To conduct a feasibility study to support the development of a detailed business plan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Signal transduction pathways inititiated by the thyroid stimulating hormone receptor' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content Thyrotropin (TSH) receptor mediate proliferation of thyroid cells and is implicated in hormone secretion, differentiation and tumorigenesis of these cells. TSH acts through a serpentine receptor which has been shown to couple with the heterotrimeric G-proteins Gs, Gq, Gi, G12 and G13 and to activate two main intracellular effectors: cAMP and the proto-oncogene Ras. Recently, G-protein coupled receptors have been shown to regulate cell morphology, growth, survival and transformation through the activation of specific heterotrimeric G-proteins. Depending on the G-protein coupled, distinct signal transduction pathways can be activated. It has been shown that tyrosine phosphorylation of focal adhesion proteins (paxillin, p130Cas, pl25FAK, src), kinase activity of pl25FAK, src, P13K PKC and activation of Ras family GTP-binding proteins (Ras, Rho, Rac and CDC42) can be stimulated through G-protein coupled receptors. Interestingly, these substrates have been shown to be activated and control critical molecular events in signal transduction pathways involved in the action of integrins, growth factor receptors and oncogenes. With this project we plan to identify new signalling components which can be involved in transduction pathways regulating thyroid cell growth through the activation of TSH receptor. We plan to elucidate the molecular events involved in Ras activation following TSH stimulation. In particular, we aim to examine tyrosine phosphorylation of focal adhesion proteins (paxillin, pl30Cas, Shc, p125FAK, src) in response to TSH and whether these substrates are involved in formation of molecular complexes with signalling and adaptor proteins (Grb2, Crk) following TSH-induced tyrosine phosphorylation. We plan to explore also the role of Rh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The neural basis of number space: probing connectivity and interactions between number and space processing with Transcranial Magnetic Stimulation (TMS)' (TMS) targeting Sixth Framework.

assistant: **Abstract**

By adopting a virtual lesion approach, the present project is aimed to map the brain circuitry responsible for the interaction between numbers and space in healthy adults. Some people possess a mental image of the number sequence that is spatially distributed and can be used to carry out calculations. People without an explicit number form nevertheless represent numbers spatially, in Western cultures with small numbers toward the left of mental space and large numbers towards the right. It is still unclear to what extent space and number processing are intermingled in the brain, and whether number magnitude representations can be dissociated from their mental spatial representation. Also, it is unclear whether mapping numbers onto a mental space is an instance of a domain-general cognitive mechanism rather than a domain specific feature.The present project is aimed to address these questions with transcranial magnetic stimulation (TMS), a technique that allows one to unveil causal rather than correlational relations between brain circuits and cognitive processes. In case of anatomical overlap, functional overlap will also be tested by probing time intervals in which specific cortical circuits are necessary for normal number and space processing. In the long run, this study will be beneficial for educational practice, since it could clarify the role of spatial representations in shaping number understanding.The project will allow the applicant to build on technical and conceptual skills acquired during her PhD at the University of Padova and University College London, and refined during her post-doctoral training at University College London. The host institution will provide the applicant with the opportunity to use and develop its TMS facilities, also in view of combin