RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Mechanical characterization of soft tissue in vivo by microstructural imaging and physics-informed neural networks: bridging the gap between biomechanics and clinical practice'.

assistant: **Concept**

Computational biomechanics is a fast-growing area of science. However, many of its fruits have not yet been translated into clinical practice. The main barrier to the translation of computational biomechanics into clinics is the lack of information about patient-specific mechanical properties of biological tissues. There are some methods for partially assessing these properties, but they have substantial limitations. A major cause of these limitations is the operating principle of current approaches, which rely on the analysis of the response of a tissue to some form of mechanical loading in vivo. To overcome this bottleneck, we propose a paradigm change. We will develop a method to infer mechanical properties of soft biological tissues in vivo based on a fundamentally new operating principle. To this end, we will leverage the synergy of three scientific areas covered by the three principal investigators of this project: (i) magnetic resonance imaging (MRI), (ii) experimental biomechanics, and (iii) physics-informed machine learning. Specifically, we will develop a new type of subvoxel MRI relaxometry to probe tissue microstructure non-invasively and establish a combined experimental and computational framework that will uncover for the first time the mechanistic link between transcriptomics, microstructure, and mechanical properties of soft biological tissues in a detailed manner. By leveraging this information with novel physics-informed machine learning techniques, we will gain the ability to determine the mechanical properties of soft tissues from clinical MRI data and blood samples with unprecedented accuracy and completeness. Our approach will be a crucial steppingstone to translate biomechanical computational models into clinical practice at a large scale. As a p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Coevolution between the great spotted cuckoo and its host, the magpie. Effect of egg appearance on the evolution of egg discrimination by the host'.

assistant: **Objectives**

Different mechanisms have been proposed allowing the host a better ability to recognize parasite eggs, (1) the evolution of a low intra-clutch variation in appearance of own eggs and (2) the evolution of a high inter-clutch variation. In this project I propose to test the following predictions: 1) the probability of rejecting model cuckoo eggs by individual magpies should be negatively related to intra-clutch variation 2) a positive relationships between rejection rate and inter-clutch variation of the different populations, and 3) intra-clutch variation of one magpie population should decreased because of sympatry. To do that I will analyse colour photographs of the eggs from ten different magpie populations in relation to i) whether the magpies ejected parasite eggs, and ii) whether intra- and inter- clutch variation were related among population to the level of rejection and parasitism. I will also analyse the same populations of hosts at different times (one century of diference) for an evolutionary change in the appearance of host eggs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Formal methods Europe: information resources' in the context of a Fourth Framework call.

assistant: **Objectives**

To allay the apprehensions of organisations considering using formal methods, possibly for the first time, by providing them with information based on experience to date which will help in their decisions processes and strategy formation. This will be done by setting up information resources about formal methods and make them available via the World Wide Web, specifically information on tools, existing applications, bibliographies, frequently asked questions, and to publish a newsletter and other information via leaflets and conference presentations.ACTIONSWWW sites in at least 8 Community countries providing links to pages of information about formal methods; a six-monthly newsletter; other promotional material.- Subject matter: information on formal methods, their applications, support tools, experience of use, etc.- Target Audience: European software developers who might use formal methods but need more advice and information about their effectiveness, experience of use, advantages etc.- Dissemination mechanisms: Databases of tools, applications, FAQs, and Bibliographies freely available via the WWW; a newsletter and other promotional activities.EXPECTED IMPACTThe project hopes to reach several hundred industrial organisations with the newsletter and other information, to gather around 50 entries in the tools and applications databases and some hundreds of items in the bibliography, and to generate a committed new interest in formal methods in an initial number of organisations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Decoding neural circuits controlling sleep drive and sedation'.

assistant: **Innovation**

Sleep and anaesthesia are both commonplace states that involve reversible loss of consciousness. However, the precise regulatory mechanisms underlying both still remain elusive, particularly at the circuitry level. Previous studies suggest that sleep is homeostatically regulated and it has been proposed that the interaction between circadian rhythm and intrinsic sleep drive determines sleep status. Although much efforts have been made, the sleep field still lacks clarity regarding the nature of the “sleep drive” as well as how it modulates sleep homeostasis. My host lab recently revealed that neuronal ensembles in the PO area, particularly in the lateral PO (LPO) area, a small region at the base of the brain that contains a mixture of sleep-active, wake-active, and temperature-sensitive neurons, are selectively activated during recovery sleep and drug-induced sedation. These results indicate that the LPO neurons are able to sense the sleep drive. In this proposal my goal is to identify LPO associated functional connectivity encoding sleep drive and sedation. By combining TetTagging functional ensembles of neurons with in vitro and in vivo optogenetics, electrophysiology and imaging techniques in mouse, I aim to 1) evaluate alterations of excitatory/inhibitory inputs onto the defined LPO neurons during prolonged wakefulness and sedation; 2) identify the origin of inputs onto the defined LPO neurons; 3) tdetermine the effects of altered connectivity involving active LPO neurons on sleep and sedation status in vivo. The results of the proposed research will provide novel insights into the regulatory mechanisms underlying sedation and the homeostatic drive of sleep.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Applying novel analytical methods to elucidate bio-nano interactions at individual cell level in plants' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Phytonanotechnology (use of Engineered Nanomaterial, ENMs, in agriculture) supports the controlled release of agrochemicals (e.g., fertilizers, pesticides) and target-specific delivery of biomolecules (e.g., nucleotides, proteins, and activators) for increased disease resistance, nutrient utilization, and crop yield. Along with the groundbreaking potential of such techniques, one should be careful about their trophic transfer to plants. This topic has been rarely studied, compared to the toxic effect of ENMs in human systems. However, assessment of ENM toxicity to plant cells is critical to the implementation of nanotechnology in agriculture and support of global sustainability and the EC's European Green Deal.   The proposed project addresses potential key cellular processes involved in the delivery of ENMs to plants and the safe use and social acceptance of phytonanotechnology, assessing potential adverse effects, including the risks associated with the transfer of ENMs through the food chain. To do so, novel analytical techniques are essential that could study metal-based ENMs and their distribution within individual cells. The development of Single Particle ICP-MS (SP-ICP-MS) is a new area of research which allows rapid detection and analysis of ENMs in a variety of matrices and applications, as it allows discrete pulses of positively charged ions to be detected and measured in a time resolved manner using microsecond data acquisition rates. PhytoENM will go beyond, applying the concept of Single Cell ICP-MS (SC-ICP-MS), where individual cells are rapidly analyzed for their particulate & ionic content, something that has not been done before in plants. The project will also use novel stable-isotope labelling techniques pioneered by the applicant team. This would all
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Centre for Marine Chemical Ecology - Integrating ecological processes with molecular mechanisms' (CEMACE) targeting Sixth Framework.

assistant: **Abstract**

Chemical ecology has uncovered a wealth of knowledge in terrestrial systems. Equivalent research in marine systems is in its infancy. This new frontier in marine science is further expected to guide bioprospecting in the search for novel bioactive substa nces and materials. Major research challenges within marine chemical ecology are the role of toxins in microalgae, function and synthesis of exuded bioactive molecules, presence of chemical communication in plants and animals, and anthropogenic interfere nce with natural receptor-ligand mechanisms. The Centre for Marine Chemical Ecology" at Göteborg University - Tjärnö Marine Biological Laboratory (TMBL) with Akademiska Hus (AH) as property owners,is a strategic concentration of research effort involvin g leading researchers, instrumentation and new laboratory facilities with unique access to the marine environment. TMBL is developing a reputation as one of few research environments dedicated to marine chemical ecology with a world-wide network of colla boration. EU support would provide an opportunity to take the next exciting step by integrating mechanistic research on molecular, ecological and evolutionary levels. Our multidisciplinary approach, involving analytical chemistry, biohydrodynamics, genom ics, ecophysiology, and evolutionary ecology, will open marine biology to disciplines and scientists outside of traditional marine biology. EU support will create an integrated scientific environment within Europe that provides novel opportunities for i ndustrial collaboration and which will equip a new generation of young scientists with the skills required to manage our marine resources in the coming century. Support through the Construction of New Infrastructure will be used to extend our current inv estments in labor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Conserving the Legacy of Evolution into the Future' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Conserving the Legacy of Evolution (CLEF) would provide a comprehensive framework for translating biodiversity datasets into conservation plans. We now have a unique opportunity to improve the outlook for biodiversity by taking advantage of the wealth of newly available data on species ranges, functional characteristics, and phylogenetic data. CLEF proposes to: (1) develop sophisticated, yet easy-to-use biodiversity models that improve our understanding of where diversity occurs and better predict how diversity might change in the future, and (2) integrate the output of these biodiversity models with systematic conservation planning. CLEF would advance a new generation of biodiversity modelling that considers multiple species in one step rather than the standard practice of estimating species diversity by aggregating individual models. Early work has suggested these multi-species biodiversity models show great promise for improving present and future biodiversity estimates, but these models have yet to be comprehensively tested. Here, we will build and test these models for plant species in the French Alps, and compare the outputs to existing process-based models at identical scale and resolution. The second phase of CLEF is to develop a tool that directly uses the outputs of these models in conservation prioritization software. This tool will have the option of including phylogenetic, functional data, and future distributions by building on recent developments in this area. CLEF will demonstrate this approach for 2700 plant species to assign conservation priorities for the entire French Alps Region considering functional diversity, evolutionary diversity, climate and land-use change and protected area status. The methods resulting from CLEF could be used for any specie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SOX: Short distance neutrino Oscillations with BoreXino', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

We propose to realize an experiment sensitive to a large fraction of the parameter space for short distance neutrino flavor oscillations into sterile components.The experiment aims at the clear and unambiguous discovery, or at the definitive disproof, of the so called neutrino anomalies, a set of circumstantial evidences of electron neutrino disappearance at short distance from the source observed by several experiments. The interpretation of the anomalies as oscillations into sterile neutrino components is also supported by cosmological data, which consistently indicate that the total number of neutrinos might be larger than three.If successful, we will demonstrate the existence of sterile neutrinos, opening a brand new era in fundamental particle physics and in cosmology. A solid signal would mean the discovery of the first particles beyond the Standard Electroweak Model and would have profound implications in our understanding of the Universe.In case of a negative result, we would close a long standing debate about the reality of the neutrino anomalies, probe the existence of new physics in low energy neutrino interactions, provide a measurement or a limit of neutrino magnetic moment, and give Borexino a superb energy calibration, very beneficial for high-precision solar neutrino measurements.The experiment will be done by placing a well designed artificial neutrino (or antineutrino) source close or inside the Borexino solar neutrino detector at the Laboratori Nazionali del Gran Sasso. The superb Borexino sensitivity, its large size, and its very low radioactive background will be the key elements of the experiment.The expected sensitivity, calculated with high precision Monte Carlo simulations which implements the deep knowledge of the detector response developed by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Environmental estrogens (EEs) and the neuro-endocrine regulation of reproduction in fish?' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Environmental estrogens (EEs) are a heterogenous group of chemicals containing natural and synthetic estrogens and xenoestrogens. EEs are pollutants of the freshwater environment and exert the biological activity of estrogenic hormones. Concern has been expressed over the possibility that EEs disrupt the endocrine regulation of reproduction in wildlife and/or humans, and the information available at present suggests that it is very plausible that EEs have such effects. However, the evidence that EEs constitute a real problem is meagre. Only when serious effects of EEs are recorded will it then be necessary to unravel the molecular mechanisms that govern these effects, and to develop strategies to manage EE-related risks. Therefore, the present proposal aims to evaluate EFFECTS of four relevant and representative EEs on the neuro-endocrine regulation of reproduction in freshwater fish. Reproduction in all vertebrates from fish to mammals is regulated by a neuro-endocrine system, the brain-pituitary-gonad (BGP) axis. Estrogens play a pivotal role in this regulatory system in both males and females. Previous work demonstrated that EEs induced, in male fish, the otherwise female-specific production of yolk proteins or inhibited testicular growth. However, also the brain-pituitary part of the BPG axis may be affected by EEs. After all, endogenous estrogens regulate the (i) amount of brain neurohormones involved in reproduction (e.g. gonadotropin releasing hormone - GnRH); (ii) expression and/or release of GnRH receptors and of gonadotropic hormone (GTH) by pituitary gonadotropin cells; (iii) testicular sex hormone synthesis. Effects of EEs on the core-components of the BPG axis are suspected to have a significant impact on reproduction because of possible consequences for se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Technologies for European Surveys of Travel Behaviour', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Improve the current practice of long-distance travel behaviour surveys, crucial in European transport policies for transport infrastructure, transport regulation and financing.1) Assessing the technology: new computing, communication and information tools are currently being implemented or adopted, i.e. setup-boxes for the tv, GPS-Systems, personal organizers, GSM telephones etc. - suitability of these wider developments for travel diary survey work -.2) Real-time recording of travel diaries: Palmtop-computers and other portable tools, such as GPS units, should allow complex, real time travel diary surveys without overburdening the respondents. Appropriate test survey and will test in the field to establish the longer term potential of this approach.3) Supporting the respondents: the increasing availability in and familiarity of household with computers opens the possibility to conduct travel diary surveys with home computers. Basing the survey on this tool will allow the combination with other tools such as geographical information systems, which can be used to make the data entry task easier, as well as more consistent through error checking. Developing of an appropriate survey and test it in the field to establish to longer term suitability.4) Enriching the travel diary results with GIS: GIS are profoundly changing the coding and storing of travel diary data. It will focus on how GIS-support could improve the coding of the routes chosen by travellers. 5) Parsing travel diary results by developing a AI-based parser of coded travel diary results, which would check the entries for completeness and consistency thereby enhancing the quality and speed of this crucial processing step.6) WWW-interface to travel diary results by establishing a WWW-based interface between the