RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multilevel approaches to understanding chronic inflammatory diseases.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The MAP-ID project aims to deliver an East-West Europe-integrating training programme for PhD students, focused on tackling one of the most challenging, complex, and therapeutically unmet problems which are chronic inflammatory diseases. MAP-ID will train chronic inflammation-oriented researchers to become leaders in the field in regional, national, and international arenas. Within the doctoral programme, 13 DCs will conduct their research under the supervision of prominent specialists from the Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University in Poland (JU), in collaboration with international partner academic institutions  and biotech companies. MAP-ID focuses on multilevel approaches to understanding chronic inflammatory diseases, including infectious, autoimmune, allergic disorders, and cancer. To achieve this goal, the programme will establish and strengthen ties and collaborations between JU and top Universities and non-academic partners in Europe and beyond. MAP-ID aims to foster interdisciplinary research spanning molecular, cell, and structural biology, biophysics, chemistry, pharmaceutical sciences, and bioinformatics with a significant contribution of OMICS data sets. The training will give the DCs a detailed insight into the strategies and mechanisms required to contribute to growth in the sector of academic and industrial research related to chronic inflammatory disease research and development. The training will include courses conducted by both host institution researchers and visiting scientists from world-leading Universities and companies. Some of the courses offered for DCs, created specifically for MAP-ID, will be accessible to other JU researchers, enriching the learning resources available to them. Therefore, the MAP-I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Energy-Efficient Highly Accurate Data Prefetching' (Berti-Chip), addressing dissemination and exploitation.

assistant: **Impact**

Data prefetchers are ubiquitous in current high-performance computers such as those manufactured by Intel, ARM, AMD, or IBM, as they play a fundamental role in hiding long-latency memory accesses. Prefetchers predict the data that will be needed by a processor in the future and fetch such data ahead of execution. State-of-the-art data prefetchers, push the limits of performance but often without caring about energy efficiency. The energy efficiency of a prefetcher is dictated by its accuracy, which measures the percentage of data moved by the prefetcher that satisfies the processor demands.Berti is a data prefetcher sited at the first-level data cache (L1D) that makes a compelling case for timeliness and accuracy. Berti can boost processors performance by 33% (with respect to those not using prefetching mechanisms) and 8.5% (when compared to mainstream prefetchers) while providing an accuracy above 90%, which translates into a low energy overhead of the memory hierarchy. In addition, Berti is a cost-effective prefetcher that just requires 2.55KB of storage.The objective of this project is to elaborate a hardware design for the Berti data prefetcher, as we strongly believe that the notable boost in processor performance and efficiency along with its design simplicity makes Berti a serious candidate both for the emerging low-power edge market and for high-performance computers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'More Open Electrical Technologies' in the context of a Sixth Framework call.

assistant: **Objectives**

In line with the vision 2020, MOET aims to establish the new industrial standard for commercial aircraft electrical system design, which will directly contribute to strengthening the competitiveness of the aeronautical industry. MOET will also contribute reducing aircraft emissions and improving operational aircraft capacity. Recent National and European research activities and state of the art commercial aircraft developments, have launched more advanced approaches for on-board energy power management systems. These benefits have also been recognised in North America where this is being given special consideration. A step change is necessary to remove current air and hydraulic engine off-takes and further increase the electrical power generation capability.This in itself will require significant changes to current electrical generation and network techniques. After Fly by wire, the Power by Wire concept (PbW) will enhance aircraft design and use by power source rationalisation and electrical power flexibility. This will be achieved by developing the necessary design principles, technologies and standards.Over a 3-year period, MOET will permit to:- Validate scalable electrical networks up to 1MW considering new voltages and advanced concepts including system transformation of future air, actuation and electrical systems into all electrical solutions,- Assess the PbW concept integration at aircraft level considering a more composite environment and the interfaces with the avionics world,- Build a design environment aiming to design and validate standardised solutions and a coherent set of platforms open to the full supply chain, in order to develop an optimised high performance PbW concept.MOET is a consortium of 62 European partners from 15 countries composed of univers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'The Role of Complement in Susceptibility to Infection and Chronic Disease'.

assistant: **Objectives**

1. Optimization of purification and storage of complement proteins and their distribution to other laboratories.2. Comparison of monoclonal and polyclonal antibodies and assay reagents testing of their utility in assays of complement component concentrations and complement fixation.3. Production of selected antibodies and assay reagents on a scale sufficient for distribution.4. Use of antibodies and assay reagents to screen for complement component deficiencies in patients and controls.5. Detailed study of complement component interaction with microorganisms of current public health interest.Human resistance to microbial infection is mediated by humoral and cellular effector systems. A major part of the humoral immune system is complement. Complement consists of a group of 30-35 soluble and cell-surface proteins which recognize and are of utmost importance in the elimination of viruses, bacteria, fungi and multicellular parasites. Complement is a major mediator of clearance of immune complexes, viruses and bacteria from the blood. Diminished complement activity, arising from genetic defects or from consumption of complement, causes humans to become susceptible to repetitive fulminant or severe infections, and/or to suffer from immune complex deposition diseases, such as systemic lupus erythematosus, rheumatoid arthritis and renal disease. Excessive complement activation, occurring after tissue injury or massive infection, leads to acute or chronic inflammation, and itself directly causes damage to host tissue. The proteins of the complement system are well-characterized at the molecular/biochemical level, and many functions of the proteins are understood from in vitro experiments. In vivo, however, the complexity of function of the complement system is incompletely unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nano-engineered aluminosilicate cementitious materials' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The project “Nano-Engineered Aluminosilicate Cementitious Materials” (NEASCMs) is designed for training the fellow by preparing low-carbon cementitious binders for sustainable construction and solidification/stabilization, S/S. Effects of nanoengineering on the regulation of the hydration and hardening processes of aluminosilicate-based cementitious binders for sustainable constructions, as well as its roles on the solidification/stabilization of aluminosilicate-based grains/wastes for environmental protection will be explored. Nanoengineering will be utilized for preparing low-carbon cementitious materials containing of different sources of Aluminosilicates, Carbonates and Sulfates (ACS) binders for sustainable construction. The hydration kinetics and performance of ACS binders will be tailored through the optimization of a combination of cement and minor ions (such as Mg, Fe, Cl). The mechanical properties and durability will be systematically studied for evaluation of performance. Secondly, effects of nanoengineering on S/S of typical aluminosilicate-based grains/wastes for environmental protection will be investigated. Solidification/stabilization using nanoengineered aluminosilicates will be studied and modelled thermodynamically. Cases such as solidification/stabilization of soil/construction wastes, mining wastes will be researched, and the environment features, such as the solidification capability, the leachability of the wastes will be investigated through mechanical testing and sequential extraction procedures (SEP), etc. Life-cycle assessment (LCA) will be used for a comprehensive understanding of the sustainability of the production and utilization of the new binders, baselined against Portland cement by taking the transportation, production, usage, and rec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Statistical Inference of the Cerebellar Network'.

assistant: **Objectives**

The brain can coordinate complex sequences of actions with the accuracy of milliseconds. Where and how these neural computations occur is an open question in neuroscience.  Despite recent technological developments allowing for large-scale high-resolution functional imaging of the brain and direct neuronal recordings in behaving animals, there has been little effort in applying rigorous statistical approaches to test circuit connectivity patterns and synaptic mechanisms driving neural activity.Experimental evidence from classical conditioning and neuronal recordings have revealed that the cerebellum plays a fundamental role in fine-tuning of temporally precise behaviors. This project aims to elucidate the neural computation arising from anatomical and physiological constraints of the comparatively simple organization of the cerebellar cortical circuit, which allows the cerebellum to represent time-dependent sensory information necessary to drive behavior. Experimental and theoretical findings in the host laboratory have led to the hypothesis that dynamic synapse are a substrate for temporal representations and temporal learning. I will use sequential Monte Carlo methods to extract activity from calcium imaging data. Then I will use a generative model of the cerebellar network to infer the connectivity among the known cell types of the cerebellum as well as their synaptic properties. Finally, I will use information theory to examine the processing capacity of the cerebellar network, thereby providing new insights on evolutionary optimization of brain computation. The combination of my experience in statistical methods and the host laboratory's experience in state-of-art neural recordings and theoretical models, is a perfect match to break down the barriers to understandi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Charting Infants’ Language, Auditory, and Motor Experiences in Everyday Contexts'.

assistant: **Concept**

Infant development, including language, is shaped by infants’ experiences with the external environment. This environment is not a uniform stream of sensory input, but is structured into contexts, activities, and routines that shape the flow of experiences. Gradually developing motor abilities also enable infants to engage with these contexts in new ways, fostering opportunities for learning. Despite their significance, little is known about how the real-world contexts and infants’ own motor development influence caregiver and infant communication and the speech that infants hear, or how this structuring impacts infant language development. In addition, although constituting the majority of infants’ hearing experience and acting as cues for everyday contexts, the non-speech sound experiences of infants have not been extensively studied. To address these gaps, EveryContext aims to transform our understanding of early language development by enabling detailed, context-dependent analysis of infants’ everyday experiences. We will collect a first-ever large-scale longitudinal dataset consisting of concurrent child-centered audio and motor data from 3 to 18-month-old infants’ home environments using modern wearable technologies (~8000 hours of data). We will then develop and apply state-of-the-art computational methods to automatic description of the collected speech, audio and movement data, followed by inference of infants’ everyday contexts and activities using these data descriptors. Enabled by the contextual knowledge and detailed data descriptors, we will then study infants’ language experiences in different everyday contexts and as a function of their motor development. As a result, the project will reveal how infant language experiences are shaped by the everyday cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Light elements in irons and metal-rich meteorites: Their isotopic distribution and evolution in the protoplanetary disk' (IRONIS) targeting Horizon Europe.

assistant: **Abstract**

Knowledge of the light element (H, C, N) characteristics of planetary building blocks is key to our understanding of the development of habitable conditions on Earth. Since 'magmatic' iron meteorites originate from the metallic cores of the earliest, differentiated planetesimals, they may preserve a record of H, C, and N isotopic variations in the inner and outer solar system during the first stages of planetary accretion. Based on novel multi-light-element isotopic analyses of irons and other Fe-Ni alloy-rich meteorites and experimental simulations, project IRONIS aims to answer the fundamental questions of (i) how the distributions of H, C, and N (and their carrier phases) evolved in space and time within the earliest stages of the protoplanetary disk, and (ii) how H, C, and N were distributed between metals and silicates during planetesimal accretion, differentiation, and subsequent evolution. A major objective is to develop novel secondary ion mass spectrometry protocols for analyzing H, C, and N in situ in Fe-Ni alloy, and to combine these with 'bulk' N-noble gas analyses by static noble gas mass spectrometry. The originality and uniqueness of project IRONIS thus lies in the coupling of two state-of the-art analytical techniques, which allow the quantification of any solar gas and cosmogenic nuclide contributions. Only once the effects of these secondary components are understood, can spatiotemporal isotopic variations in the protoplanetary disk be investigated. In parallel, new cross-calibrated N analyses of experimental run products will provide constraints on the degree of N isotopic fractionation during alloy-silicate partitioning, and will permit us to assess if the N isotopic compositions of irons represent a primary feature of their parent bodies. Ultimately
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Genetically modified skeletal muscle cells as a tool gene replacement in genetic disorders.' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Skeletal muscle is an important target for human somatic cell gene therapy applications. These include systemic delivery of recombinant gene products for correction of genetic or acquired disorders, as well as gene therapy of inherited muscle diseases. The aim of this project is the development of safe, efficient and reliable methodologies for gene transfer into human muscle cell progenitors, to obtain stable and regulated production of recombinant proteins into, or by, skeletal muscle fibres. Vectors, gene transfer technology and pre- clinical models will be developed to test the use of genetically modified fibres to produce either circulating proteins of biological interest (e.g., hormones, enzymes, cytokines), or structural or enzymatic proteins missing or abnormal in congenital muscle disorders (e.g., dystrophin). The experimental strategies will be specifically aimed to obtain regulated expression of the transferred gene for systemic protein delivery, and on production of significant numbers of genetically modified muscle fibres for therapy of primary myopathies. Most of the work will be carried out on primary human muscle cell progenitors, which will be transduced in-vitro mainly, although not exclusively, by replication- defective retroviral vectors. Transduced cells will be studied both in cell culture and in-vivo, after transplantation into regenerating muscle of immunodeficient mice to generate human-mouse hybrid fibres. For systemic delivery of circulating proteins (al-antitrypsin and IL-4 as initial models), we will study stability, long-term persistence and quantitative expression of genes transduced in a variety of retroviral vectors. Development of muscle-specific vectors producing the necessary amount of protein under the regulation required for each spe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Single Nanoparticle Catalysis' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Imagine a sustainable society where clean energy is produced from sunlight, and water is converted into hydrogen to fuel a fuel cell, which produces electric energy to power the electric motor in a car. At the same time, CO2 emissions are captured and converted to hydrocarbons that are again used as fuel or as resource for fine chemical synthesis. At the heart of this vision is heterogeneous catalysis. Hence, for it to become reality, tailored highly efficient catalyst materials are of paramount importance. The goal of this research program is therefore to establish a new experimental paradigm, which allows the detailed scrutiny of individual catalyst nanoparticles and their reaction products under application conditions.The catalytic performance of nanoparticles is directly controlled by their size, shape and chemical composition. Current studies are, however, conducted on ensembles of nanoparticles. Therefore, such studies are plagued by averaging effects, which deny access to the key details related to how size, shape and composition control catalyst performance. To eliminate this problem, we will nanofabricate a unique nanofluidic reactor device that will enable us to scrutinize catalytic processes and products at the individual catalyst nanoparticle level. In a second step, we will integrate plasmonic optical probes with the nanoreactor to be able to simultaneously monitor the dynamics of the catalyst particle state during reaction.Finally, we will apply the nanoreactor to investigate the role of the catalyst oxidation state in Fischer-Tropsch catalysis. In parallel, we will explore novel plasmon-induced hot electron-mediated reaction pathways for catalytic CO2 reduction, as part of a carbon-neutral energy cycle. We anticipate unprecedented insight into the role of