RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Epilepsy Treatment Using Neuromodulation by Non-Invasive Temporal Interference Stimulation' (EMUNITI).

assistant: **Innovation**

Epilepsy is a brain disorder characterized by sporadic debilitating seizures and declines in mental health. Available therapies suffer from drawbacks and are not suitable for all patients. The medical needs in epilepsy encapsulate those for clinically managing brain health in general, i.e., the need for precision, personalized, non-systemic and safer therapies. Potential innovative solutions are available from advances in technology but will require multidisciplinary teams which bridge between engineering and clinical neurology.The main objective of the EMUNITI project is to develop a breakthrough, non-invasive, personalized brain stimulation device for epilepsy patients, (i) as a diagnostic for seizure localization which can guide subsequent surgical resection; and (ii) as a therapy, akin to immunizing the patient against seizures. The device is based on temporal interference (TI) of electrical signals delivered from positions around the scalp. The project will be led by Adam Williamson, who is a former recipient of ERC Starting and Proof-of-Concept grants and has IP for the technology. His lab is at the interface between state-of-the art engineering and neurology, and is based in a major European centre for clinical research on epilepsy in Marseille, France. His lab has already demonstrated in a pilot study of epilepsy patients, that TI can block seizure-provoking brain activity.The project includes three work packages (WPs). WP1 focuses on optimizing TI stimulation at the engineering level and establishing a novel form of TI in multipolar TI (mTI). WP2 will evaluate mTI in epilepsy patients, for seizure localization and for therapeutic intervention with the potential to create brain seizure immunity through repeated mTI. WP3 administers the project and delivers the m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Patient-specific Microstructural and radIobiological model for persoNalised external beam radiatIONn therapy in localised tumourS' to be submitted under Horizon Europe.

assistant: **Abstract**

External-beam radiotherapy has been established as best practice care in different cancer cases, although current models applied in the clinics to tune the treatment plan dosimetry, as a function of the expected tumour response and radiation-induced toxicity, do not make use of patient-specific information, but rely on radiobiological parameters typically derived from in-vitro experiments, thus abdicating from describing the in-vivo complexity of the pathology. MINIONS is a cutting-edge research programme that investigates and integrates a set of activities to implement patient-specific microstructural and radiobiological models in personalized radiotherapy treatment planning and adaptation towards a detailed description of tumour characteristics of each patient and thus significantly improved tumour control probability. The main challenge of MINIONS is to create, for the first time, a real-time patient-specific model able to describe the microscopic characteristic of the tumour and its interaction with the radiation beam. The scientific activities of MINIONS are to achieve and merge: (i) Monte-Carlo (MC) simulations of Diffusion Magnetic Resonance (DW-MR) signals and radiation-tissue interactions on a library of in-silico cellular substrates to obtain an integrated simulation platform; (ii) real-time Artificial Intelligence-based techniques to accelerate MC simulations and make them compatible with fast treatment planning and adaptation; (ii) advanced DW-MR imaging, to retrieve non-invasively the information required to feed the simulation platform for the implementation of patient-specific microstructural and radiobiological models. The design of in-vivo and ex-vivo tests allows validating the model performance and the collaboration of researchers, engineers and clini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Blastworthy textile-based luggage containers for aviation safety'.

assistant: **Objectives**

The rise in worldwide terrorism has required measures be taken to harden aircraft against catastrophic in-flight failure due to concealed explosives. Commercial aviation can be protected from the threat of explosives by : 1. preventing explosives from reaching the aircraft  2. mitigating the effects of an explosive protecting the aircraft from an onboard explosion. The risk that a small quantity of an explosive, below the threshold of the detection instruments, could get undetected should be considered, and the introduction of contermeasures to reduce the effects of on-board explosions should be considered.  This is the idea behind FLY-BAG.  Hardened containers (HULD) have been developed for the latter scope, but have some disadvantages which prevent their wider utilisation: they are heavier and more costly than standard luggage containers and only applicable to wide-body aircrafts. The issue of containing explosions aboard narrow-body aircraft must be resolved.  Our concept is based on the development of flexible textile-based luggage containers able to resist a small to medium explosion by controlled expansion and containment of the shock waves whilst, at the same time, preventing hard luggage fragment projectiles (shrapnel) from striking the main structure of the aircraft at high speed.  A multi-layered ""soft-sandwich"" structure is required to absorb the large dynamic loads of the explosion and the large deformation related to the gas expansion. Our idea is to use a multi-axial textile structures made of ballistic yarns as an internal high strength layer, coupled with an external ""foldable"" layer which could deform in a controlled way during the explosion, in a way similar to air-bags in cars. Composite elements like thin strips or thin sheets contribute with rei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'An innovative energy consumption management system based on a punctual electrical control device', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The objectives are related to the Rational Use of Energy. The amount of saved energy depends on the specific application. A pre analysis has been performed on lighting systems. Considering the actual not practicable possibility of controlling separately each consumption point of the electrical networks feeding street lighting (lamps) or commercial buildings (lamps, heaters, coolers) , and also taking into account the future possibility of managing customised contracts with the energy supplier even for private and domestic use, we can state the following Project targets: Street lighting: reduction of total energy >50% (existing and new installations) ; Large commercial buildings: reduction of total energy used 50% long term, 30,40% short term; Private houses: reduction of total energy used 10% short term, >20% long term; Reduction of maintenance costs: 80%
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Synthetic Gauge Fields in Quantum Optics' (SynOptic).

assistant: **Concept**

Synthetic gauge fields have many important physical consequences in quantum optical systems. This fast-growing topic of research is opening up new possibilities for the lossless optical transmission of information, for improved optical components, such as optical isolators, and even for fault-free topological quantum computing. We explore how to push cutting-edge experiments towards these goals by theoretically studying the interplay of synthetic gauge fields with optical nonlinearity, pumping and loss in photonic devices. The systems we shall investigate range from artificial graphene and other condensed matter models simulated with microcavities; to lattices of classical pendula and waveguides; to strongly correlated fractional quantum Hall-like states of light and their exotic excitations. Our work will have an immediate impact through international experimental collaborations and an interdisciplinary approach building on our combined range of expertise. We will exploit concepts and techniques from diverse research areas including quantum fluids, topological phases of matter, solid-state systems and non-equilibrium physics. Our project couples the investigation of novel phenomena arising from gauge fields in many-body systems with the hunt for new and improved technological applications in photonics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Experimental replication of historical reanalysis processes' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Background. In historical linguistics, reanalysis is described as process by which speakers assign a new meaning to a superficially unchanged element. Reanalysis is basic to grammar change. However, due to the methodological difficulty of studying change on the basis of historical texts and limitations in the understanding of associated social processes, current research struggles to explain both why and when reanalysis occurs and why it spreads between speakers.Aim. EXREAN has three main innovative objectives: (a) to develop a methodology that allows replicating historical reanalysis processes in a laboratory setting, (b) to determine in which context types reanalysis occurs, (c) to determine which social, language-specific, and individual factor favor or disfavor reanalysis and its actualization. Approach. The EXREAN project is the first of its kind to systematically examine reanalysis and actualization processes in a laboratory setting. EXREAN brings together and integrates insights from historical linguistics, psycholinguistics, and social psychology. Using experimental paradigms from natural language comprehension and artificial language learning, participants from typologically diverse languages will be trained to replicate three attested historical reanalysis processes from different grammatical domains. The project will test the hypothesis that reanalysis processes can be predicted from exposure to bridging contexts, social factors such as arousal and familiarity, individual differences in habit tendency, and blocking effects arising from previous experience with language.Innovation and impact. EXREAN breaks new ground by developing a methodology by which hypotheses on processes of language change can be submitted to rigorous testing. It will establish the neces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Co-option of host circadian rhythms in cancer'.

assistant: **Objectives**

Circadian rhythms (CRs) are the biological response to the periodic rotations of the Earth, and allowfundamental adaptations of organisms to a changing environment. CRs are molecularly controlled in every cellby a set of transcriptional factors that control, and are influenced by, core biological processes includingmetabolic, immune, and proliferative.My previous studies established, for the first time, that innate immune cells regulate the circadian physiologyof tissues, including the susceptibility of the lung to be metastasized. In INN-TIME, I ask the reciprocalquestion to reveal if tumors take advantage of, and subvert, CRs of the innate (immune and stroma)compartments to escape anti-tumoral defense. INN-TIME Aims to understand how oncogenic processesrewire CRs of the host and to elucidate strategies that halt this subversion as a new approach to fightcancer. Using lung cancer as proof-of-principle, I will first investigate cell-intrinsic circadian programs intumors (Aim1). Next, I will define how tumors co-opt circadian clocks of the host and explore how themolecular clock of innate immune (Aim2) and supporting stromal cells (Aim3) impacts tumor growth, bothmolecularly and functionally. By integrating multiple transcriptomics and functional approaches, INN-TIMEwill discover novel regulatory programs in tumors using a circadian approach, and pave the way to designstrategies to prevent cancer by interfering with tumor-supportive circadian programs.INN-TIME will revolutionize the way we understand cancer, as it will identify the malignant roots ofcircadian rhythms and their impact on host defense. This research will establish a new paradigm by revealingthe mechanisms underlying pro-tumorigenic clocks, and will provide robust foundations for new therapiesin a set of di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Non-destructive image-based manuscript analysis system' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The aim of this project is to produce non-destructive non-invasive image-based processing techniques to aid the historical analysis and examination of five significant Mediterranean collections of manuscripts (hosted by libraries and museums in Egypt, Jord an, Lebanon, Cyprus, and Israel). Digital images from the target manuscripts captured in colour visible, ultraviolet and monochrome infrared will be used to derive computational profiles of the ink and support (paper, papyrus, etc) used. The profiles will be based on the image properties of the materials exhibited due to either to the physical characteristics of their composition or to their manufacturing process. In particular we will use their photometric, 2D morphological and texture image characteristic s. The computational profiles augmented with historical information related to manufacture date and origin of the manuscripts and information on the scrivener will form a tool which: 1) Allow for in situ non-destructive non-invasive image-based analysis of manuscripts 2) Enable the classification of manuscript ink and supports. 3) Aid authentication and dating of manuscripts from the Mediterranean region by verifying the homogeneity of their inks and supports. 4) Enable the isolation, discrimination and ana lysis of faded or overlapping writings such as palimpsests. 5) Aid the restoration and storage of manuscripts. 6) Facilitate the historical cross-referencing of manuscripts found in the Mediterranean region. The final system following a test with undated m anuscripts from complementary collections found in Greece and southern Italy will be hosted on an XML-based online database accessible via the Internet. All historical information discovered during the project will be added to the database to aid future re sea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Definition of local anti-mycobacterial immune responses - a novel approach for the assessment of candidate vaccines against tuberculosis' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content Human and bovine TB are important problems. BCG vaccination has been used to combat human disease and is under consideration for control of animal disease. However, BCG has been unreliable in some circumstances and new vaccines are required urgently. Logical vaccine development requires precise understanding of protective immunity. Previous studies have often used unnatural modes of disease, or have ignored the crucial immune events at the site of infection/immunization. It is the objective of this study to apply the latest technology to define the local immune responses which occur in a natural model of TB in cattle. Surgical procedures will be used to harvest lymphatic T-cells after stimulation of local anti-TB immunity. Molecular immunological techniques and flow cytometry will be used to assess the function and classification of these cells in precise detail. This information will allow comparison of local responses to TB and any candidate vaccine. Training content (objective, benefit and expected impact) A primary objective is to provide training in all aspects of current immunological research (flow cytometry, lymphocyte functions, molecular immunology, Iymphatic cannulation etc.). Benefits of the training will be a researcher with very broad experience and potential to have considerable impact on TB research (considered of high priority in the EU). The benefits and impact from this proposal will include the development of a local model of infection which will be a valuable tool for assessment of novel candidate vaccines. The project will provide an increased understanding of both human and bovine tuberculosis. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Probing the bypassability of genetic constraints in drug-resistance enzymes' (PROBYDE) targeting Horizon 2020.

assistant: **Abstract**

The fast evolution of bacterial pathogens towards antibiotic resistance is estimated by 2050 to be killing 10 million people every year. Consequently, much interest is being directed towards finding ways to curb or even arrest this evolutionary process. Of note, sequencing efforts are revealing that many of the genetic changes that drive resistance evolution are often repeatable. Understanding what drives this repeatability is of foremost importance if we ever want to develop interventions aimed at anticipating and preventing the evolution of undesirable variants. Here, I will aim at advancing our understanding of evolutionary repeatability in several clinically-relevant, drug-resistance enzymes spanning a range of GC compositions. I will use this relevant model system to empirically test recent predictions on the roles of mutation bias and GC content in shaping mutational pathways. To this end, I will conduct high-throughput 'in vitro' Directed Evolution experiments to explore the potential adaptive paths available via single step mutations among the drug-resistance enzymes. Next, I will compare these 'in vitro' predictions with the outcomes of highly-parallel antibiotic adaptation experiments conducted with bacterial strains with strong mutation biases (e.g., mutators) carrying the same panel of enzymes. By producing important insights into some of the key determinants of evolutionary repeatability, PROBYDE aspires to form a knowledge base that may help harness evolution not only in bacterial pathogens, but also in other human-relevant systems such as cancer, crop pests and industrial microbes.


**Keywords:** Epistasis, Mutation bias, Evolutionary genetics, Experimental evolution, Antimicrobial resistance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Refugees’ Political Participation and State-(Re)Making in Displacement' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In todays world, the majority of refugees originate from states plagued by civil war and extreme violence, where the legitimacy of the state as guarantor of protection is unsettled. Furthermore, refugees often find themselves subjected to various forms of violence at the hands of state actors in host states  regardless of whether they seek refuge in authoritarian or democratic ones. Yet, little is known about how refugees perceive and engage with the state throughout their displacement journeys, and how these perceptions shape their roles as political actors: How do they experience and perceive the state, and in the context of state-inflicted violence in particular, before, during and after displacement? How do these perceptions and experiences affect their political participation? Centring refugees political agency, the RESTATE project aims to: (1) provide a dynamic understanding of refugees experiences and interactions with the state along their displacement journeys; (2) discern which forms of state violence, both within refugees origin and host states, erode trust in state institutions and potentially incite political resistance; (3) theorise the conditions of refugees political participation throughout their displacement trajectories; and (4) theorise the implications of refugees political participation in both origin and host states for processes of state-making  attempts to fulfil key government functions such as protection, justice, the provision of basic services and mobility control. Employing a novel comparative mixed-methods and multi-sited approach, the project studies displacement from three civil-war states (Afghanistan, South Sudan and Syria) in four major host states (Iran, Turkey, Uganda, and Germany) for innovative theory-building on refugees politica