RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Flame retardant rare fibres fabrics for the aircraft industry' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The proposal addresses the problem of meeting increased fire safety regulations in the expanding market of private and executive aircraft with the consumer demands for unique, aesthetically pleasing interior fabrics from rare fibers such as alpaca and mohair. The aim is to design a model science and technology to ensure each unique fabric will pass the required fire test criteria.The objectives are:1. to analyze existing fabrics which match the new fire regulations2. to produce experimental fabrics using fiber, yarn and fabric variables3. to select and apply suitable flame retardant finishes and determine their effect4. to produce a model to predict the optimal fabric parameters which guarantee a pass when tested. Prototype materials will be subject to performance tests according to the relevant European and international standards.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Modelling of the passive mode-locking in fibre lasers'.

assistant: **Concept**

The aim of this project is to investigate theoretically the properties of a passively mode-locked fiber laser in order to optimize a desired operating regime.Different operating regimes will be explored such as short-pulse generation in both normal and anomalous dispersion regime, generation of bunch states, generation of bound states, harmonic passive mode-locking and also Q-switching and unstable behaviours.Predictions of the model will be compared with experimental data obtained in our laboratory with an erbium-doped double-clad fiber laser. The approach will be numerical and also analytical. The final goal is to clearly identify the exact experimental conditions allowing to optimize a given operating regime.To reach this goal it will be necessary to study the interaction of pulses inside the laser resonator. In particular, special attention will be given to classify the different interactions depending on their attractive or repulsive nature or on the range of interaction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Modern homotopy theory' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Students are attracted by areas that are flourishing and there is a demand for training in homotopy theory across Europe greater than it has been for decades. The topics mentioned are technically advances an few post-doctoral fellows will have a detailed knowledge of more than one area. The training programme has three components:(a) to appoint post-doctoral fellows (and exceptionally advanced PhD students), typically for periods of not more than twelve months, to spend time working with teams in the centre,(b) to run instructional workshops,(c) to ensure that young mathematicians participate fully in small working research meetings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Osmotic Wearable Bolus Injector (oWBI) for viscous drug delivery'.

assistant: **Objectives**

With more drugs coming onto the market as combination products, i.e. drug products paired with delivery devices pharmaceutical companies are paying closer attention to integrated delivery systems. Due to: 1) the trend in the change in drug formulations, in order to migrate from intravenous to a more cost-effective and convenient subcutaneous (SC) drug administration; and 2) the trend in moving from synthetic derived drugs to biologically drugs that are more complex and have higher viscosity and therefore require delivery of larger doses; resulted in the need for a new class of injection devices - wearable bolus-injectors (WBIs). WBIs are prefilled, disposable devices that are worn on the body of a patient during the SC self-administration of a large dose of medication. The WBI market is estimated to grow in CAGR of 170% between 2015 – 2020 and achieve €6.9Bn by 2025, and pharmaceutical companies are actively seeking for reliable and cost-effective WBIs, providing optimal injection performance at an attractive unit cost and low cost of customization.Subcuject ApS (SCJ) is a medical device company set to commercialize a new class of WBIs - Subcuject - that makes use of the simple, predictable and strong force of nature: osmotic pressure. Unlike the current WBIs, Subcuject is fully mechanical, bearing no electronic components, resulting in a more flexible, reliable and eco-friendly device at a remarkably lower cost than competitor’s (75 - 86% cost reduction). SCJ business strategy is based on establishing multiple licensing deals (depending on the drug type, disease, region) with pharmaceutical companies. The Subcuject device is expected to significantly enhance SCJ’s profitability, with an expected accumulated profit of €97M, 5 years after project completion. Moreover, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Learning to Create' under Seventh Framework.

assistant: **Concept**

Lrn2Cre8 aims to understand the relationship between learning and creativity by means of practical engineering, theoretical study, and cognitive comparison. We begin from the position that creativity is a function of memory, that generates new structures based on memorised ones, by processes which are essentially statistical. Thus, the project is situated in the tradition of frequentist statistical models of mind, and it builds on statistical understandings of perception of sequence (these are not naive 1st-order statistics) to consider its domain at the level of sequence processing in terms of percepts. Representations of these percepts are also learned, in parallel with the structural information in the data itself, and the guiding principle is one of information efficiency: the representations conspire to produce the most efficient possible representation of the data in memory. In Lre2Cre8, we wish to avoid the problem of extrinsic domain reasoning (e.g., physics in the real world) so we use music as our domain; extrinsic reasoning for music is small in comparison. We propose to build systems that take musical data as input, both in continuous and discrete forms, and learn the necessary representations and structure to memorise it efficiently. We hypothesise that this is a cognitive model of human musical behaviour, and we will test our hypthesis though empirical studies and experiments that compare the behaviour of our computational models with human behaviours. We will study the relationship between our well-understood and cognitively validated learning mechanisms and creative behaviour, in musical composition and performance. We aim to devise new methods for evaluation of creative behaviour in machines and humans, and to apply them, comparatively, to creative proc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Climate, Landscape, Settlement and Society: Exploring Human-Environment Interaction in the Ancient Near East', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Over the last 8000 years, the Fertile Crescent of the Near East has seen the emergence of cities, states and empires. Climate fluctuations are generally considered to be a significant factor in these changes because in pre-industrial societies they directly relate to food production and security. In the short term, ‘collapse’ events brought about by extreme weather changes such as droughts have been blamed for declines in population, social complexity and political systems. More broadly, the relationships between environment, settlement and surplus drive most models for the development of urbanism and hierarchical political systems. Studies seeking to correlate social and climatic changes in the past tend either to focus on highly localised analyses of specific sites and surveys or to take a more synthetic overview at much larger, even continental, scales. The CLaSS project will take a ground breaking hybrid approach using archaeological data science (or ‘big data’) to construct detailed, empirical datasets at unprecedented scales. Archaeological settlement data and archaeobotanical data (plant and tree remains) will be collated for the entire Fertile Crescent and combined with climate simulations derived from General Circulation Models using cutting edge techniques. The resulting datasets will represent the largest of their kind ever compiled, covering the period between 8000BP and 2000BP and an area of 600,000km2. Collecting data at this scale will enable us to compare population densities and distribution, subsistence practices and landscape management strategies to investigate the question: What factors have allowed for the differential persistence of societies in the face of changing climatic and environmental conditions? This ambitious project will provide insight
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Scale-up of the Europe Startup Nations Alliance as a European Digital Infrastructure Consortium and a catalyst for a startup-friendly reform in Member States', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

ESNA has been created in 2022 with the vision of “becoming a leading Entity for the EU agenda for entrepreneurship and contribute to bring Europe to the lead of global startup ecosystem” and the mission to “support the signatory countries and provide concrete support to policy makers in implementing the best policy practices outlined in the EU Startup Nations Standard”.Two years on, and the organisation is clearly on the path to achieve both its vision and mission. A formal entity has been created in Portugal to allow the start of activities, as a first-of-a-kind body which has grown in resources, skills and specially in adhesion of member states, counting today 19 countries as a strong and very representative majority of the signatory countries of the SNS, and with continued negotiations for the inclusion of further members. In terms of activities, ESNA has initiated its pivotal role of monitoring of SNS adoption, with the launch of the SNS Scoreboard, first as a Baseline in 2022 and then as a first annual report in 2023, and the start of a new policy lab to support countries accelerating SNS implementation through best practice benchmarking, sharing and exchange.These ESNA initial activities have been pivotal in helping EU member states moving beyond the aspirations of the political declaration and into concrete implementation and benefiting from a strong participation of ESNA's signatory members, as demonstrated by the 91% response rate to the SNS Scoreboard 2023 inquiry. But in spite of ESNA’s significant advancements in terms of Member State adhesion and activities, there is still a need for an evolution in terms of a legal framework which is better aligned with its truly European role, as well as consolidating the breadth of its activities, namely in the area of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New Strategies for Controlling Polymer Sequences' to be submitted under Seventh Framework.

assistant: **Abstract**

Sequence-controlled polymerizations play a key role in Nature. Although formed from a rather modest library of monomers, sequence-defined macromolecules such as proteins or nucleic acids are largely responsible for the complexity and diversity of the biological world. By analogy, one may predict that synthetic sequence-defined polymers could play an important role in modern applied materials science. Paradoxically, very little effort has been spent within the last decades for developing sequence-specific polymerization methods.In this scientific context, the target of the present proposal is to develop new approaches for controlling macromolecular sequences. In particular, new possibilities for controlling comonomer sequences in standard synthetic processes such as chain-growth polymerizations (e.g. controlled radical polymerization) and step-growth polymerizations will be investigated. The strategies for controlling sequences will be principally chemical (e.g. controlled monomer insertion, organocatalysis, sequential monomer additions) but physical (e.g. confinement, transient monomer complexation) and eventually biochemical (e.g. biocatalysis) routes will be also considered.The essence of this project is indeed highly fundamental. Indeed, the control over polymer sequences remains one of the last  holy grails  in polymer science. Nevertheless, on a longer term, this research may be also extremely relevant for applications. Indeed, sequence-controlled polymers are most likely the key towards new generations of functional sub-nanometric materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The role of Rac1 and Rac3 in cortical interneuron development' (RACS), addressing dissemination and exploitation.

assistant: **Impact**

GABAergic interneurons play important roles in cortical function and provide the main source of inhibition to cortical microcircuits. Impaired interneuron function results in severe neurodevelopmental disorders such as schizophrenia, epilepsy and autism. Although recent studies have uncovered some of the molecular mechanisms underlying interneuron development, the intracellular components involved are still unknown. Our proposed work, aims to elucidate the role of specific signalling cascades during birth, migration and specification of interneurons, and thus shed light on the intracellular machinery that regulates their proper development.Rac proteins integrate multiple extracellular signals and are required for many processes in diverse cell types, including cytoskeleton organization, vesicle trafficking, transcription, cell cycle progression, and apoptosis. We are interested in elucidating the roles of Rac1 and Rac3 specifically in MGE-derived interneurons, a population that comprises the majority of cortical interneurons. We have used conditional Rac1 deficient mice (specifically in the MGE) combined with Rac3 null mice and we found that 50% of MGE derived GABAergic interneurons fail to migrate and populate the cortex. MGE-derived interneurons missing both Rac proteins show an even more severe defect (80%). The aim of this proposal is to elucidate the mechanism of Rac1 and 3 action in interneuron development by assaying for: a) the polarity and the involvement of actin/microtubule dynamics in Rac deficient interneurons, b) the nature of the defect in interneuron progenitors as it concerns cell cycle behaviour c) the individual role of each of the two Rac proteins and the involvement of downstream effectors of the Rac pathway and d) the functional properties of inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Analysis of fos-induced bone tumor development and the role of the tumor suppressor genes p53 and rb'.

assistant: **Innovation**

To study the cooperativity of Fos and the tumor suppressor genes p53 and Rb in the pathogenesis of osteosarcoma in vivo transgenic mice overexpressing exogenous Fos will be crossed with mice deficient for p53 and mice with an inactivated I gene. The phenotype of the offspring will be characterized and compared to littermates expressing only the Fos transgen Analysis of the murine transgene. and derived cell lines will include morphology and the expression of AP-1-associated genes as well as skeletal markers. The same investigations will be performed for tissues and cell lines derived from neoplastic and non-neoplastic human bone. The second objective of the research project is to generate transgenic mice overexpressing Fra-l to study the effect of this member of the Fos gene family on bone formation und tumorigenesis. By crossing Fra-l transgenic mice with Fos mutant mice, the issue of genetic rescue of the osteopetrotic phenotype of Fos mutant mice will be addressed. Training content (objective, benefit and expected impact) The work at the l.M.P. will provide me with an intensive training in the molecular basis of bone diseases, especially of bor tumors. The laboratory training will include standard techniques, but also demanding in vivo methods. The training will enable me to perform independent biomedical research later.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Adipocyte Differentiation and Metabolic Functions in Obesity and Type 2 Diabetes'.

assistant: **Innovation**

Obesity associated disorders such as T2D, hypertension and CVD, commonly referred to as the “metabolic syndrome”, are prevalent diseases of industrialized societies. Deranged adipose tissue proliferation and differentiation contribute significantly to the development of these metabolic disorders. Comparatively little however is known, about how these processes influence the development of metabolic disorders. Using a multidisciplinary approach, I plan to elucidate molecular mechanisms underlying the altered adipocyte differentiation and maturation in different models of obesity associated metabolic disorders. Special emphasis will be given to the analysis of gene expression, postranslational modifications and lipid molecular species composition. To achieve this goal, I am establishing several novel methods to isolate pure primary preadipocytes including a new animal model that will allow me to monitor preadipocytes, in vivo and track their cellular fate in the context of a complete organism. These systems will allow, for the first time to study preadipocyte biology, in an in vivo setting. By monitoring preadipocyte differentiation in vivo, I will also be able to answer the key questions regarding the development of preadipocytes and examine signals that induce or inhibit their differentiation. Using transplantation techniques, I will elucidate the genetic and environmental contributions to the progression of obesity and its associated metabolic disorders. Furthermore, these studies will integrate a lipidomics approach to systematically analyze lipid molecular species composition in different models of metabolic disorders. My studies will provide new insights into the mechanisms and dynamics underlying adipocyte differentiation and maturation, and relate them to metaboli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Novel Photodissociable Ruthenium-Based Anticancer Drugs' to be submitted under Seventh Framework.

assistant: **Abstract**

The discovery of cisplatin, cis-diamminedichloroplatinum(II), as an anticancer drug is a landmark of modern inorganic medicinal chemistry. Platinum drugs are the best-selling antitumor drugs in the world and they are effective in treating a variety of cancers. During the last decade, the search for new anticancer compounds has been widened to other transition metals. Ruthenium complexes in particular have shown considerable promise because of their rich synthetic chemistry, the range of oxidation states, the common octahedral geometry, and finally also because of their rich photochemistry. The fundamental goal of this project is to investigate the possibility of developing new types of hybrid ruthenium-based chemotherapeutic drugs that can be activated by irradiation with low-energy light. When irradiated these molecules form reactive aqua species and, at the same time, release biologically active ligands. The ligands can interfere with the cell cycle at a number of targets, while the metal-containing aqua species inhibit mitosis by binding to DNA. The proposed approach can lead to development of milder, more specific, and tunable drugs which can decrease the negative side-effects of chemotherapy. Inorganic and organic synthetic methodologies, advanced spectroscopic and analytical techniques will be used together with biochemical and medical methods to pursue the objectives of the project. The multi- and interdisciplinary nature of the research will prompt the applicant to acquire practical and theoretical skills on chemical biology and medical chemistry, to improve his independent thinking and leadership qualities, enhancing his scientific competencies and helping the applicant to attain an independent position.