RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Genetics and epigenetics of animal welfare'.

assistant: **Concept**

Animal welfare is a topic of highest societal and scientific priority. Here, I propose to use genomic and epigenetic tools to provide a new perspective on the biology of animal welfare. This will reveal mechanisms involved in modulating stress responses. Groundbreaking aspects include new insights into how environmental conditions shape the orchestration of the genome by means of epigenetic mechanisms, and how this in turn modulates coping patterns of animals. The flexible epigenome comprises the interface between the environment and the genome. It is involved in both short- and long-term, including transgenerational, adaptations of animals. Hence, populations may adapt to environmental conditions over generations, using epigenetic mechanisms. The project will primarily be based on chickens, but will also be extended to a novel species, the dog. We will generate congenic chicken strains, where interesting alleles and epialleles will be fixed against a common background of either RJF or domestic genotypes. In these, we will apply a broad phenotyping strategy, to characterize the effects on different welfare relevant behaviors. Furthermore, we will characterize how environmental stress affects the epigenome of birds, and tissue samples from more than 500 birds from an intercross between RJF and White Leghorn layers will be used to perform an extensive meth-QTL-analysis. This will reveal environmental and genetic mechanisms affecting gene-specific methylation. The dog is another highly interesting species in the context of behavior genetics, because of its high inter-breed variation in behavior, and its compact and sequenced genome. We will set up a large-scale F2-intercross experiment and phenotype about 400 dogs in standardized behavioral tests. All individuals will be g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Investigation of novel vertical take-off and landing (VTOL) aircraft concept, designed for operations in urban areas' (VTOL).

assistant: **Innovation**

Principal objective of proposed project is computational and experimental investigation of novel concept of VTOL aircraft with nickname „Anuloid“ regarding its flight properties and flying qualities, and compare „Anuloid“ to helicopters, tilt rotor aircraft, or other VTOL aircraft concepts, in relation to potential utilization for transport missions in urban areas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High-throughput peptidomics and transcriptomics of animal venoms for discovery of novel therapeutic peptides and innovative drug development' (VENOMICS).

assistant: **Concept**

Animal venoms are complex cocktails of peptides that have enormous potential as novel therapeutic leads. Replicating in vitro the diversity of venoms by generating large synthetic combinatorial peptide libraries will solve the challenge of working with limited amounts of natural products and permit high-throughput investigation of their pharmacology. A new investigation paradigm associating transcriptomics and proteomics is the only way to achieve this goal and to address the complexity of this unexplored 40,000,000 peptide resource. The vision of the VENOMICS project is to develop, integrate and implement cutting-edge and innovative technologies in a high-throughput approach to investigate the enormous structural and pharmacological diversity of venom peptides. We will use the largest venom and venom gland collection in the world to generate a comprehensive sequence database of bioactive peptides, and produce a 10,000 reticulated peptide bank to be used in drug discovery efforts and development of novel therapeutics. A 1000-fold improvement in throughput over the current situation (1 to 2 candidates generated per year) is reasonably foreseen.Implementation of the project will require both improvements and the integration of exisiting technologies in a high-throughput workflow comprising venom and tissue sourcing, mass spectrometry-based automated de novo peptide sequencing, transcriptomics of venom gland-derived RNA or cDNA/EST libraries, bioinformatics, implementation of a sequence database, and highly parallel synthetic or recombinant production including peptide refolding. The last step will be the validation of the approach in functional assays targeting specific pathologies. VENOMICS is a high-impact project with societal (new drugs against life threatening diseas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Securing local supplY chains via the development of new Methods to assess the circularity and symbiosis of the Bio-bAsed industrial ecosystem enhancing the EU competitiveness and resource independence' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The SYMBA project aims at creating a new and innovative IS method to be replicated within EU according to the local/regional bio-based industrial ecosystem. SYMBA will implement a user-friendly and accessible AI database suggesting regional IS innovative processes to create zero-waste value chains, ensuring more local supply chains; a better distribution of economic and social benefits among the stakeholders and an increase in the economic value of final products. SYMBA solution, aligned with the EU Bioeconomy Strategy, is based on a threefold approach:1)Creation and validation of new IS methodology for the bio-based sector, starting from existing knowledge and lessons earned from SYMBA consortium partners.2)Individuation of criteria to select regional hubs3)AI database including Monitoring tools, waste relation matrix, networking and cooperation with ongoing EU and local networks.  The partnership has been intentionally selected by its expertise, network with key external stakeholders and geographical reach, bringing together 5 EU countries (IT, ES, BE, NL, DE) to consolidate the maximum outreach of the initiative. It consists of 9 partners with complementary competences: 4 RTD centers (CIRCE, CTB, AIMPLAS; CET); 1 large industry (NVMT); 1 pilot facility (BBEPP); 1 innovative SME (ENCO) and 2 networks (CKIC and ICLEI) with a valuable background in applying IS approach in the bio-based sector, providing services to companies and creating awareness and networking among citizens, policy makers, EU initiatives. Through the involvement of different industrial sectors: agri-food (NVMT); packaging (AIMPLAS); wastewater (CET); textile (CTB); waste valorisation (BBEPP), SYMBA will demonstrate how to shift from a linear to a circular economy contributing to deliver bio-based sol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Vaccination against river blindness (ONCHOCERCIASIS)' (ONCHOCERCIASIS) targeting Fifth Framework.

assistant: **Abstract**

The purpose of the research is to elucidate immune mechanisms and specificities that correlate with parasitological protection in three complementary systems: i) the target system of Onchocerca ovules in humans ii) the closely analogous system of Onchocerca change in cattle (which permits experimental manipulation in laboratory and field settings); iii) in the mouse model of Litosomoides sigmodontis (which permits detailed immunological analysis in a host supporting complete development of a filarial nematode.) In combination, these systems allow us to address the basis of naturally acquired immunity (against developing larvae and/or microfilariae) through immunoepidemiological and case-controlled comparisons (using defined antigens and parasite extracts); the basis of vaccine-induced immunity (using defined antigens and irradiated larvae); the impact of chemotherapy (both adulticides and microfilaricides ) on protection; and the effects of immunomodulation mediated by chronic infection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Geometry and Topology of Open Manifolds'.

assistant: **Objectives**

The purpose of this project is to study the interactions between Riemannian Geometry and the topology of open manifolds. A general question is to find the best Riemannian metric on a given manifold; a related question is to understand the topological consequences of the existence of a metric with given properties. This programme has already been highly successful in the compact case whereas basic questions are not answered in the open case. The key tool which ought to be used in the three items is the Ricci flow with bubbling off,  in dimension 3, described by myself and my collaborators. This opened the way to applying Ricci flow to non-compact manifolds and it is a breakthrough which gives a very optimistic approach to some deep conjectures. The study of Whitehead manifolds will open a wide realm of research  since results are scarce. This will provide work for quite a few graduate students and for several years. My goal is to make such a significant progress that the subject will become proeminent in Riemannian Geometry. Again, for this the Ricci flow will be an unavoidable tool. Constructing explicit Riemannian metrics with various properties is another goal, which pertains to the same circle of ideas, and will lead to a systematic study of these spaces. This is a new and groundbreaking direction of research. I have already obtained some results in these direction and I intend to go much further and to enhance my national and international collaborations using the grant if accepted.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'KNOW-HOW: A new framework for theoretical and practical control across intelligence domains' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Knowing what is true is valuable, but practical knowledge – knowledge how to do things – is equally critical. Having such ‘know-how’ enables us to succeed in action, and achieve our goals. Currently, little consensus exists across philosophical and empirical disciplines about the nature of know-how and what is involved in exercising it. Research results are siloed across epistemology, action theory, philosophy of language, and cognitive science, and fundamental disagreement persists about whether research questions about know-how primarily concern cognitive processes or behavioral manifestations. These theoretical barriers hinder our ability to recognize and utilize know-how effectively.KNOW-HOW aims to make a major advance here by developing a comprehensive framework for understanding know-how and its place in a wider web of concepts we rely on to understand and describe intelligent behavior across a range of activities we care about and depend on. A novel hypothesis to be explored is that know-how disposes us not just to success but to creditworthy control. This control, it is proposed, takes a theoretically unified form in both intentional action and judgment, revealing how know-how enhances performance in a structurally symmetrical way when we deliberate and when we act. With minimal metaphysical commitments, the framework applies to both biological and artificial intelligence, avoiding ad hoc explanations and preserving theoretical unification across areas of philosophy that have yet to benefit from each other's shared resources. KNOW-HOW will put our understanding of know-how on a new footing, impacting academic research across disciplines.


**Keywords:** virtue epistemology,  know-how,  intentional action,  practical knowledge,  action theory,  epistemology of k
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a Cavity Supported Lipid Membranes Biomimetic drug permeability models (CLIMB)' (CLIMB).

assistant: **Concept**

Permeability Assay (PAMPA) have limited biorelavance and can often be poorly predictive of  of drug permeation, particularly for charged species and for complex membranes such as the BBB and particularly of membrane toxicity which remain key issue leading to high attrition rate and low productivity in the pharmaceutical industry. The proposed fellowship programme aims to address these issues in a very novel way by developing  lipid bilayers supported on cutting-edge Plasmonically-Directed Nano-Structured porous arrays.  The substrates prepared via a range of fabrication methods, including 2-photon 3D-nanoprinting, will allow for  investigation of drug-membrane interactions, and permeability through a unique and novel principle, whereby the arrival time of single or few weakly- or non-fluorescent molecules at plasmonic volume in the nano-/micro-cavity is monitored via enhanced spectroscopic technique.  Angle dependent Raman microscopy will permit study independently of the drug-membrane interactions and plasmonic hot spot so both structural and permeation times can be meausered and these studies will be carried out in parallel with Elelctrochemcial impendence spectroscopy of membrane integrity.  This approach will dramatically advance the state-of-the-art in membrane assay. In parallel it provide high quality research training to the MRSA fellow along with, supported by the host institution training programme a range of career promoting transferable skills acquired.  Leading the fellow to a fully-independent academic position.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Marks of Spectres: Mind, Morality, and Religion in Cultural Discourse""'.

assistant: **Innovation**

My project will expedite my entry into a position of professional maturity by allowing me to engage in a sustained programme of research, training and dissemination activities at the Institute for Cognitive and Evolutionary Anthropology (ICEA), University of Oxford, UK.In the first instance, I will embark on a research programme that uses methods developed in cognitivist approaches to religion to analyse a recurrent topic in literary, intellectual and political discourses––the use of supernatural rhetoric to frame the articulation of moral norms. I will show how all of these ostensibly secular discourses articulate, in coded form, the same innate intuitions that link supernatural agency with the enforcement of moral imperatives in religious discourses. I will pursue this agenda by way of four case studies, which will focus on Indo-European narrative, nineteenth-century fiction, psychoanalytic discourse and European political rhetoric.In addition to my research agenda, I will engage in a series of training activities in my host university.  Under the guidance of the scientist-in-charge, Professor Robin Dunbar (Director, ICEA), I will engage in programme of directed reading and research in cognitive anthropology.  Supporting this, I will attend graduate courses in cognitive and social-scientific methodologies offered by the ICEA.  Also, I will undertake training in developmental psychology and sociology by way of graduate seminars in the Departments of Experimental Psychology and Sociology.  Finally, I shall receive complementary skills training in research management from the Oxford Insitute for LearningMy project's knowledge deliverables will come in four forms: a monograph in the Macmillan series 'Cognitive Studies in Literature and Performance,' three journal articles
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Complex Research of Earthquake’s Prediction Possibilities, Seismicity and Climate Change Correlations', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The purpose of project BlackSeaHazNet is development of long-term research cooperation through coordinated joint program of researcher’s exchange. The base is Complex Program for research of possibility for forecast earthquake’s time, place (epicenter, depth), magnitude and intensity using reliable precursors. Precursors research includes regional geophysical and seismological monitoring, monitoring of water sources and their Radon, Helium, Mercury concentrations, crust temperature, monitoring of electromagnetic field under, on, and above Earth surface, meteorological monitoring, including earthquake clouds and electrical charge distributions, near space monitoring, aimed to estimate Earth, Sun and space (cosmic rays) origins of variations, and biological precursors. For many variables well working monitoring exists (for example INTERMAGNET geomagnetic field monitoring). For others (for example: monitoring of Earth currents distribution) monitoring have to be created. Due to complex real time variables monitoring the parallel output of the Program can be different time scale estimations for other natural hazards and risk assessment, as well as the correlations between human behavior and electromagnetic and other geophysical variables variations. Proposed regional network can be considered as first step for creating wide interdisciplinary scientific consortia for formulation of more adequate models of today Climate change, Earth seismic processes as well as different time scales regional earthquakes forecasts. Which will the bases for future EC framework , regional and  bilateral Projects. The scientific and practical results will be considered in workshops and regional training seminars.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Mediterranean forecasting system pilot project'.

assistant: **Concept**

This proposal defines the research strategy for the implementation of a Mediterranean Forecasting System which aims at the prediction of coastal primary producers variability from the time scales of days to months. Such a predictive capability is required to sustain an healthy coastal environment and its management. A forecasting system of such kind requires two essential components, an observing system and a numerical modeling/data assimilation component that can use the past observational information to optimally initialize the forecast. The technical rationale of the Project is based upon the hypothesis that both hydrodynamics and ecosystem fluctuations in the coastaVshelf areas of the Mediterranean are intimately connected to the general circulation. The second assumption is that, for the purely physical components of the ecosystem, monitoring and numerical modeling can be demonstrated to work almost pre-operationally. In fact, a major goal of the proposal is to show that Near Real Time (NRT) forecasts of the large scale basin currents are possible. In this proposal we develop and implement: 1) a pilot automatic temperature monitoring system for the overall Mediterranean Sea (Voluntary Observing Ship-VOS system) with NRT data delivery; 2) a pilot Mediterranean Multisensor Moored Array buoy system (M3A) which could automatically monitor a complete set of physical parameters, such as temperature, salinity and currents, together with relevant biochemical and optical measurements in order to establish the feasibility of multiparametric monitoring of the upper thermocline in the whole basin; 3) NRT satellite data (sea surface height, sea surface temperature and color) pre-processing procedures in order to show that satellite data corrections of such complex remotely sens