RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Inkless by Tocano – Printing without consumables' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Current printers use ink as a consumable resulting in high operational costs and the production of approximately 2.3 Billion litres of environmentally unfriendly chemicals per year. The main objective of the overall innovation project is to provide a solution for inkless printing. The production, replacement, and refilling of cartridges/toners itself also have significant effects on the environment, due to the chemicals that are used, the production process (electricity, logistics etc.), and the disposal of empty cartridges/toners through landfilling. Another concern is the release of dust and ozonisation during operation, which causes health problems and air pollution. The innovative solution of Tocano B.V. provides an inkless printing technology that will overcome these issues. As a result the European environment will strongly benefits as CO2 emission is reduced up to 65 kton/year. The proposed valorisation of Tocano’s solution represents a potential total value increase for the European economy of approximately EUR 6 Billion/year. The long term ambition of Tocano is to achieve a market share of 10% in the monochromatic printing market. This is a significant step towards a sustainable and cost competitive printing industry. In this feasibility assessment the final hurdles will be taken towards a market introduction supported by a convincing demonstration of the inkless printing technology in an operational environment throughout Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The translational landscape of virally infected cells' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Viruses are completely reliant on the host cell machinery and have evolved many mechanisms to hijack it for their propagation. At the same time our cells have developed defense mechanisms to cope with infections. A key way by which viruses influence host physiology is through interaction with the cellular translation machinery. Not only viruses must co-opt this machinery to translate their own mRNAs, they also have to hinder host defenses that are aimed to inactivate the translation machinery. My research aims to elucidate the complex cellular changes that occur during these virus-cell encounters with a focus on the translation machinery. I plan to concentrate on two major pathogens; a large DNA virus, Human cytomegalovirus (HCMV), and a small RNA virus, Influenza A. Although these viruses are very different, for both of these viruses the global effect of infection on the translation of host genes is still poorly defined. I therefore propose to tackle this important issue  by employing a novel deep-sequencing technique termed ribosome profiling, that allows a comprehensive view of translation events. The robustness, scale and accuracy of this analysis will enable us to determine the identity and the relative levels of translation of each host protein during the course of infection and would therefore provide valuable information regarding translational control strategies used by these viruses to reprogram the cellular host translation machinery.  I then plan to develop and apply more directed experiment to confirm translational changes and to elucidate their importance to viral replication. These experiments should provide a unique opportunity to understand the underlying changes that occur during infection and to reveal common and unique pathways that viruses use to ha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Women's Invisible Ink: Trans-Genre Writing and the Gendering of Intellectual Value in Early Modernity' (WINK).

assistant: **Innovation**

Literature scholars have succeeded in recovering texts by early modern women from different languages, genres, and sociopolitical contexts. Still, compared to their male counterparts, few women writers feature in national canons, or they compose a separate set of ‘early modern women writers’. A nuanced qualitative approach to their textual production reveals forms of self-taught, intellectually-minded trans-genre discourse (traversing poetry, drama, prose, novels) traditionally deemed irrelevant as it did not conform to a practice of scholarly male-dominated discourse. Thus, much original thinking by women has remained intact even if their texts are available to us. The proposed research locates, identifies and examines the invisible written production of women in early European modernity in order to modify the single-gender paradigm of intellectual value. It surveys sources in six languages through a methodology based on trans-genre writing rather than on close genre types, allowing patterns of persuasive argumentation to emerge as intellectual input, while exposing the rhetorical models that have impinged on the social and cognitive processes identifying intellectual value as being androcentric. The main research unfolds in three strands: 1) Synergies, examining religious and life-writing themes that shaped into ethical discourses on the common good. 2) Cloud intertextualities, tracing fragmented chains of intuitive argument in discursive narrative. 3) Textual porosity, understanding patterns of knowledge transference and authorial attribution in the management of sources.The research outcomes will render co-authored articles, a virtual space environment as the reservoir and task field for comparative textual analysis, and a four-volume collection on the cultural hist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Targeting oxidative repair proteins for treatment of cancer and inflammation' (TAROX) under Horizon 2020.

assistant: **Objectives**

Oxidative damage and defects in DNA repair are frequently underlying many diseases, e.g., cancer, autoimmune diseases, ischemia/reperfusion injury, neurodegenerative disorders, viral diseases and ageing. Although some molecular understanding into oxidative DNA lesions and repair proteins exist, a thorough understanding on the link to diseases is largely missing, and therapies exploiting oxidative DNA damage and repair have not emerged. Here, we will study mechanisms of nucleotide metabolism and oxidative DNA damage and repair, and generate tools and make use of ‘omics’ approaches to explore the function of the Nudix and glycosylases family enzymes in relation to oxidative metabolism. Furthermore, we will progress and understand the basic mechanisms how oxidative DNA lesions are processed and kill cells. Importantly, we will develop small molecule inhibitors targeting Nudix and glycosylases, e.g. MTH1, NUDT15 and OGG1, and use our newly developed inhibitors to increase our knowledge of these enzymes in oxidative metabolism and disease. We will further optimize these inhibitors into drugs and explore therapeutic approaches in cancer and inflammation as well as in exploratory studies in a variety of diseases involving oxidative stress. Altogether, in this programme we contribute to deepen our knowledge into the fundamental biology of oxidative stress and its links with disease, and providing the scientific community with an innovative repertoire of selective inhibitors for numerous enzymes involved in repair of oxidative lesions. This will enable exploratory basic science discoveries as well as potential novel therapeutic interventions ‘outside the box’. The programme will also generate high value to the industrial competitiveness of Europe in form of novel inhibitors for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Evolutionary mechanisms of epigenomic and chromosomal aberrations in cancer'.

assistant: **Concept**

Our working hypothesis is that tumorigenesis is an evolutionary process that fundamentally couples few major driving events (point mutations, rearrangements) with a complex flux of minor aberrations, many of which are epigenetic. We believe that these minor events are critical factors in the emergence of the cancer phenotype, and that understanding them is essential to the characterization of the disease. In particular, we hypothesize that a quantitative and principled evolutionary model for carcinogenesis is imperative for understanding the heterogeneity within tumor cell populations and predicting the effects of cancer therapies. We will therefore develop an interdisciplinary scheme that combines theoretical models of cancer evolution with in vitro evolutionary experiments and new methods for assaying the population heterogeneity of epigenomic organization. By developing techniques to interrogate DNA methylation and its interaction with other key epigenetic marks at the single-cell level, we will allow quantitative theoretical predictions to be scrutinized and refined. By combining models describing epigenetic aberrations with direct measurements of chromatin organization using Hi-C and 4C-seq, we shall revisit fundamental questions on the causative nature of epigenetic changes during carcinogenesis. Ultimately, we will apply both theoretical and experimental methodologies to assay and characterize the evolutionary histories of tumor cell populations from multiple mouse models and clinical patient samples.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'New Imaging Head for Digital Offset Printing Presses'.

assistant: **Innovation**

NIMED will develop a new imaging head that will increase the speed, decrease cost and improve the ease of maintenance of Karat Digital Press's new digital offset press, the 74 Karat. The 74 Karat is designed to deliver high quality colour prints with a short job preparation time. The press includes a special imaging head that exposes the printing plates on press. However, the current imaging head has drawbacks of speed, cost, and ease of maintenance. The new head will overcome these and enhance the 74 Karat's competitiveness and speed up the market penetration of digital offset presses. Project objectives include the development of novel opto-electronic components suited to the unique application requirements of imaging on-press, and their integration into an innovative imaging head. Development includes a high power array of laser diodes; LCD reflective screen for spatial modulation of high power radiation; supporting microelectronics and optics; and data transfer manipulation capability. Other applications include PCB manufacturing and CTP.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Development of Key Application Scenarios and Market Drivers for Polytronics'.

assistant: **Concept**

Polytronics is not primarily a replacement for existing electronic technologies, but opens up the prospect of completely new applications of plastics. In the scope of these new findings it seems possible that polytronics may solve new problems and adds new functionality to microelectronic circuits and systems. Polymers have the potential to better fulfil the requirements of green electronics and to lead to a better sustainity. But polytronics will only hold this promise if major roadblocks can be solved. To master this challenge major institutions and companies are working together in order to adapt visions and reality in the frame of a reliable matrix of technologies and key application areas, and to find synergies to microelectronics. This project aims to filter and to channel the available knowledge. Important tools for this purpose will be focussed workshops and expert meetings by building an international network.OBJECTIVESThe project aims to develop an application scenario describing the needs and expectations in the important field of polytroncis. The term polytronics has been selected because of its merge of polymer electronics, micro electronics and opto-electronics, and therefore best describes the target field of our scenario. The project will collect all relevant facts of the status world-wide and develop on this basis consensus between the partners about the future needs. Based on the results, future R&D activities can be decided, and the directions for projects/initiatives with FP6 will be given. To achieve these goals key experts in Europe in the field of polytronics are working together: Leading institutional partners are supported by co-operation of leading industrial partners.DESCRIPTION OF WORKThe project will set major focus on polytronics. However,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Universities by night' (2002-2006) under Sixth Framework.

assistant: **Objectives**

The U*NIGHT project will take place on 22 September in 4 Bulgarian cities - Sofia, Rousse, Varna and Stara Zagora, and will complement the pan-European festive events on the Researchers Night 2006.The project activities comprise a well-targeted and rich communication strategy at both, national and regional levels in Bulgaria, focused on researchers personality, their human face and career path. They complement the EU continuous efforts of making Europe attractive for researchers and bringing researchers closer to society, and young people in particular.The main goal of U*NIGHT project is to raise public recognition of researchers and to encourage young people in Bulgaria to embark on a technology and scientific careers. The following project objectives are defined: -to improve the appreciation of researchers as professionals and personalities by the general public and by young people, in particular; -to raise the public understanding of the contribution of researchers to social and economic progress and development; -to make researchers' careers attractive for young people.U*NIGHT will take place on a public holiday in Bulgaria - the Independence day, and will provide opportunity to people to celebrate with researchers. The publicity campaign will attract young people and citizens to meet with researchers at a party in university, at a cup of coffee or in a lab, to visit a gala concert of researchers, or specially designed children programs and exhibitions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Keeping ready for battle: understanding fundamental mechanisms of establishment and maintenance of epigenetic marks underlying abiotic stress memory in plants' (EPIPRIMING) under Seventh Framework.

assistant: **Objectives**

Drought and salt stress threaten crop production worldwide. Evidence from the field that pre-exposure of plants to transient mild stress (priming) enhances their tolerance to subsequent harsher stress indicates that plants maintain a ‘memory’ of environmental events that allows them to respond more efficiently to subsequent stress. However, systematic studies on the molecular processes underlying abiotic stress priming are scarce. The proposed project takes advantage of an effective salt-priming protocol for the model plant Arabidopsis thaliana developed by the host group, and builds on recently publishedevidence from the host that epigenetic marks consisting of a decrease of tri-methylated lysine 27 in histone 3 (H3K27me3) underlie somatic stress memory of the primed plants. The work will focus on elucidating the molecular mechanisms for the establishment, maintenance and fading of the epigenetic memory and the role it plays for improved stress tolerance. The main objectives are the following: (1) testing the role of REF6 (a plant histone demethylase), SWI3B (a component of a chromatin-remodeling complex) and nucleosome repositioning in priming-induced H3K27me3 loss, (2) investigating the mechanisms of H3K27me3 spreading after priming, (3) assessing the effect of repeated salt exposure on H3K27me3, and (4) detailed analysis of cell-type specific H3K27me3 changes in the HKT1 gene, encoding a sodium transporter with a crucial role in plant salt tolerance. The research will use a range of modern technologies including chromatin immunoprecipitation (ChIP), next-generation (Illumina) sequencing, quantitative PCR, nucleosome mapping and the use of INTACT technology for cell-type specific ChIP, combined with refined data analysis to obtain results at a high spatio-temporal/mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Phylogenetic analysis of spatial and temporal patterns of community biodiversity'.

assistant: **Objectives**

The major goal of the present project is to develop innovative statistical methods for analysing community biodiversity, a highly timely objective within the current efforts for preventing biodiversity loss. Most of current biodiversity studies exclusively focus on the number of species and/or the relative abundance of the species in communities. Recent research has been undertaken to measure biodiversity by considering functional or phylogenetic information. However very few studies combine these two important aspects into a single analysis and when they do, the relative abundance of species is not included.The present project combines these three interrelated criteria for a better description of community diversity: species abundances, functions of specie s in communities and their evolutionary relationships through phylogenies. The project tackles the complex question of the relative influence of species functions, species history, and random ecological processes of birth, death and dispersal on biodiversity.This research will provide two innovative statistical developments:(1) a decomposition of biodiversity, accounting both for the phylogeny and the functional traits of species and separating the effects of each, and(2) an associated spatial analysis.These new statistical methods will allow the description of patterns of community diversity from simulated and field data. The simulated data obtained by advanced mathematical models will enable the fellow to identify key processes, related to either neutral or adaptive theories, underlying the observed biodiversity patterns. This fellowship will be held at the University of Oxford, which will provide the fellow with training in mathematical biology and statistical analysis of phylogenies. This, together wit h the vari
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MIniature Co-operative RObots advancing towards the Nano-range', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

MiCRoN aims at bridging the micro and the nano worlds by developing a prototype of a multi-microrobot manipulating system to handle µm-sized and mesoscopic objects with nanometre precision. The system will be based on a cluster (5 to 10) of small (cm³) mobile robots each equipped with onboard electronics for control and communication. These robots will be able to co-operate autonomously in order to accomplish tasks ranging from the handling of biological cells to the assembly of micro-parts. Advanced novel tools as well as SPM probes will be integrated in the robot platform. Selected wireless robots will be equipped with CMOS cameras to provide live high-magnification scene images that will be fed to an integrated machine vision system for scene interpretation. Several other subsystems will also be developed, such as a global positioning system and a wireless power supply unit.OBJECTIVESThe objective of the proposed project is the development of a multi-microrobot manipulating system to handle µm-sized objects as well as smaller nano-scale objects. The system will consist of a cluster of small mobile autonomous robots. These wireless agents, each equipped with onboard electronics, co-operate within a desktop environment to execute a range of tasks related to assembly and processing from the nano- to the micro-range. The proposed system comprises several essential subsystems such as a global positioning system to provide accurate position information (resolution ~1 µm) of each microrobot, advanced manipulating tools and wireless power supply.DESCRIPTION OF WORKThe project commences with the specification of the experiments, which will serve as a test-bed for the robot system throughout the project. The first experimental scenario involves the 3D assembly of an instrument