RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identification of signal transduction molecules as targets for biotechnology-derived immunosuppressive drugs', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The objective of this project is to employ a multi-disciplinary approach to identify novel targets for second generation immunosuppressive drugs which would be biotechnology derived and in the long-term, based on rational drug design. The targets which will be analysed lie on the IL-2 signalling pathway leading to T cell growth. Selective suppression of this pathway, by inhibiting a key signalling component, would block IL-2 induced T cell expansion and thus suppress the ability of the immune system to respond to insult. The validity of analysing this signal transduction pathway is based on the finding that the novel immunosuppressant, rapamycin selectively abrogates IL-2 driven T cell growth by interfering with IL-2 intracellular signalling. Indeed, the inhibitory effects on cell growth are closely paralleled by the selective block of IL-2 induced p70s6k activation and subsequent activation of cyclin D2,D3-cdk4/cyclin E-cdk2 complexes, without effecting other kinases whose activation is induced by IL-2. Recent evidence points to PI3K as being the critical upstream enzyme in initiating the p70s6k signal transduction pathway. Activation of PI3K leads to the increased production of PI(3,4,5)P3 and the predicted activation of xPKC, which has been hypothesised to be the upstream p70s6k kinase. The aim of this proposal is to (1) establish the connections between PI3K and dzeta PKC, dzeta PKC and p70s6kl and p70s6k an cyclin D1-cdk4/cyclin Ecdk2, (2) determine if the inhibitory effects on cell growth by rapamycin are exerted through p70s6k and/or cdk2/cdk4 inactivation and (3) develop in-vitro assays which can be used as chemical screens and for the generation of biotechnology derived drugs. To carry out these goals, four leading international groups, in the field of signal t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A big jump in preventing problems in refractive surgery for myopia' (KERASTOP).

assistant: **Innovation**

The treatment of myopia using the excimer laser technology has been standardized globally. It is the main business for ophthalmologists in private practice. Most of patients undergoing laser refractive surgery achieve a good outcome, but there is a reduced volume of patients that develop a devastating disease, the post-LASIK ectasia. This condition is due to the performance of surgery in eyes with a pathology called keratoconus. It is not completely understood and generates a degradation of vision, with the potential of leading to extreme conditions requiring corneal transplantation. It is a very traumatic situation for both patients and doctors.Nowadays, keratoconus is only diagnosed when clinical signs are present. Ophthalmologists search for signs in the corneal surface indicating the potential presence of keratoconus and preventing the risk for the development of the disease. This leads to the avoidance of performing surgery in a great volume of patients due to a theoretical risk of ectasia development.CORNEA PROJECT has two biomarkers directly related to the presence of keratoconus. Based on the use of these biomarkers, KERASTOP will provide a fast in situ diagnostic test, with high levels of sensitivity and specificity (over 90%) that will facilitate the doctor to determine if the pathology is present, even in very initial stages not detected with the current diagnostic tests. KERASTOP will reduce the risks in refractive surgery, will increase the volume of candidates suitable for surgery and will allow the performance of more surgeries with more safety. CORNEA PROJECT is composed of two foundational partners with more than 15 years of experience in the laser refractive surgery sector worldwide. Likewise, the company has a human team composed of very relevant expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Self-Aware CPSoCs with Hierarchical Goal Management' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

SoCs (System-on-Chip) constitute the basis of embedded systems, are highly complex and require thorough orchestration of different goals across operating system, compiler and architecture layers. State-of-the-art approaches tend to focus on a single aspect, while other critical objectives are neglected. There is no centralized arbiter that considers the priority and significance of objectives and requirements of each application, as the objectives of different applications may be overlapping or contradicting. The main research objective of this project is to propose a self-aware SoC platform with hierarchical goal management (HGM). To the best of the fellow's knowledge, this project is the first systematic approach to manage SoCs considering an arbitrary number of objectives in a complex hierarchy of competing goals and sub-goals. To this end, Cyber-Physical System-on-Chip (CPSoC), a sensor- and actuator-rich multiprocessor SoC platform developed at UC Irvine (UCI), will be used in cooperation with the UCI and TU Wien (TUW) groups. The stepping stones towards this approach will be explored in the disciplines of control theory and cognitive science by utilizing supervisory control, self-awareness, and machine learning methods. The fellow will spend two years at UCI to gain a solid understanding of hierarchical control systems and develop the basic concepts of HGM on the CPSoC platform in cooperation with TUW. Then, he will spend the third year at TUW to further develop the concepts, reinforce the system with self-awareness and online learning, and apply them in application scenarios. At TUW, he will gain a solid understanding and undertake high-level training in cognitive science while exploiting it to enhance the management strategy. This enables him to emerge from the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a flexible building system with integrated services' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The objective of this project is to develop a building system for both the housing and commercial market. Many building systems are already available worldwide, using frames (timber, steel, concrete, etcetera) and of course the more traditional block and brick and cast-concrete structures. What the systems mentioned have in common, is the focus on the structural elements of the construction and the lack of a good solution for the services. The ventilation of homes is in general not very efficient, also because of the fear to increase heating costs. A result is a bad climate, moisture problems, etcetera. The 'A+ system' is the improved version of the ISB-concept, which was developed as a prototype at the Technical University of Eindhoven. Both systems are developed to solve the 'conflict' between the constructive elements and installations/services in a building. Only through this approach an industrial building system with a high degree of flexibility can be realised. The combination of the A+ and Pluggit system can provide a building system at lower costs and better quality (energy saving, indoor climate, noise control) and the possibility to extend the lifetime of buildings : - 20% cost reduction compared to traditional systems (present standard); - at least doubling lifetime; - maintaining the traditional look of a building.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Strentening effective practice: promoting the rigorous development of clinical guidelines in europe through the creation of a common appraisal instrument' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Objectives: -To develop an appraisal instrument to compare the different approaches to guideline development in Europe.  -To identify potential areas for harmonisation of guideline development in order to minimise duplication of efforts and maximise efficiency of guideline development in individual countries.Clinical Guidelines are being used in health care systems throughout Europe to improve the quality of patient care. An increasing concern is the number of guidelines in specific clinical areas that contain conflicting recommendations. Clinicians, managers and policy makers will wish to make informed decisions on which recommendations to follow. There is a need for a common, valid and transparent approach to assessing the quality of each guideline. An essential prerequisite to the creation of valid guidelines is the identification of the underlying research evidence, explicit linking of this evidence to recommendations, and ensuring that non-evidence based recommendations are based on appropriately structured professional consensus. It is now an appropriate time to create a coordinated European approach to the appraisal of clinical guidelines. The proposed concerted action (CA) will create the framework to achieve this, providing added value to existing research programmes in individual countries. The main aim of the CA is to develop an appraisal instrument to compare the different approaches to guideline development in Europe. This approach will identify potential areas for harmonisation in order to minimise duplication of efforts and maximise efficiency of guideline development in individual countries.The tasks of the CA are to:I) Describe the guideline development processes and procedures in collaborative countries;II) Develop a common set of appraisal criteria fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Philosophy and Genre: Creating a Textual Basis for African Philosophy' to be submitted under Horizon 2020.

assistant: **Abstract**

The project pioneers a multilingual approach to African philosophy, based on an understanding of philosophy as expressed through texts. In contrast to definitions of philosophical texts as non-fictional, written sources (Hountondji), we insist on a much more inclusive definition of “text”: both oral and written texts, fictional and non-fictional ones, public and private ones are considered in this project. A rigorous study of texts, working across multiple genres and several languages, is the first step in the development of an African philosophy derived from local African cultures, rather than from global, colonial or neo-colonial concerns, as is to date the case in the “mainstream” discipline of “African Philosophy”. This project establishes such a textual basis for African philosophy. This bottom-up approach necessitates a reconsideration of the nature, methods, and themes of philosophy, but also of its textual strategies, its use of language, of the nature of representation, and of the relationship between imaginative literature and theoretical thought. The key premise of our project is that to understand the philosophical meaning of texts, it is necessary to start with an analysis of textual genres. Genres anchor texts in context, in culture and language. How exactly does genre impact meaning? To answer this central question of our research, we work comparatively on several genres of literature in eight African and European languages. The case studies include the essay in Ciluba and French, the novel in Swahili, Shona, Ciluba, Lingala, French, and English, digital texts such as blogs and social media, scenario planning narratives, Sufi poetry in Swahili and Wolof, and Alexis Kagame’s poetic work in Kinyarwanda and French, travestying the traditional genres of dynas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structural characterization of immune signaling protein TIGIT using x-ray crystallography and cryo-electron microscopy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The goal of this proposal is to obtain atomic resolution structures of TIGIT using X-ray crystallography and cryo-electron microscopy. TIGIT inhibits autoimmune responses, and anti-TIGIT antibodies can induce immune response in anti-viral and anti-tumor immunotherapies. No structures exist for the transmembrane (TM) domain of TIGIT, which is the portion of the signaling protein that transmits signals accross the membrane bilayer, and there are no structures of TIGIT bound to anti-TIGIT antibodies. High-resolution structures of full-length TIGIT and TM domain constructs will further our understanding of how TIGIT transmits signals across the cell membrane and modulates T cell activation. Structures of TIGIT TM constructs bound to PVR and anti-TIGIT antibodies will guide the design of anti-TIGIT drugs and antibodies for use in immunotherapy treatments. The candidate will carry out this structural work in the lab of Prof. Martin Caffrey, a world- renowned leader in the field of membrane protein X-ray crystallography.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'EXPLOITING METAL-MICROBE APPLICATIONS TO EXPAND THE CIRCULAR ECONOMY'.

assistant: **Innovation**

The vision for the M2EX EJD Network (EXploiting Metal-Microbe applications to EXpand the circular economy) is to bring together an interdisciplinary team of world-leading European researchers to tackle a highly ambitious scientific project, focusing on the chemical, molecular and biogeochemical mechanisms of microbially-mediated processes underpinned by metals, which will deliver the doctoral training of 15 early-stage researchers (ESRs) and a range of clearly-defined, high impact scientific outputs to advance the state-of-the-art around the management of metals in Europe’s 21st-century bioeconomy. The complementary research skills and training expertise within this inter-sectoral Network will ensure that the ESRs trained will be at the front of Europe’s next generation of innovative research leaders. The research topics revolve around the role, and potential, of metals in anaerobic biotechnologies for (i) metal recovery, (ii) bioremediation of waste streams containing high metal content or (iii) low metal content for biological applications. Thus, the focus of the research is on topics extended from the field of anaerobic bioprocesses. High-end analytical techniques and novel experimental approaches will be tested, and used, to provide training and an exceptional research environment in tackling the chemical, microbiological and biotechnological aspects of managing the ‘Metal Bioeconomy’. These areas will be explored along with modelling of the distribution and interactions of metals at the scale of elemental speciation (the ‘chemosphere’); cells and genomes (the ‘micro-scale’ and the “T-Elementome”); biofilms (at the scale of microbial communities and assemblages); and in anaerobic biotechnologies (the ‘technosphere’). Engaging projects have also been designed for the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovative Molecular Diagnostics point-of-care device for MRSA' (PoC-Cycle) under Horizon 2020.

assistant: **Objectives**

FRIZ has developed PoC-Cycle® platform- an innovative diagnostics device introducing efficient multiplex nucleic acid testing to the point-of-care. It provides a combination of accuracy and sensitivity, multiplexing, and optimized workflow from sample collection to diagnosis. Current diagnostics platforms are technically limited: On one side only few sequence signatures can be checked, on the other side, the analysis of these signatures are mostly considered in one sequence area only due to the high complexity in developing Multiplex-PCR, as well as missing process-robustness for routine administration. FRIZ implemented a multiplex analysis in disposable microfluidic cartridge format with integrated semiconductor based on microarrays for the rapid and sensitive detection of a broad range and number of biomarkers.Key market is the screening of MRSA, a pathogen with wide spread and growing negative impact to European patients and health care systems. Experts forecast the number of deaths will increase from 6,000 to approx. 17,000 in 2015. Main users of the device are hospitals as they require simple and safe handling as well as fast and reliable results. European market potential can be estimated with 900,000 tests per year resulting in a yearly turnover of almost two million €. The new diagnostic device will significantly reduce the number of infections. Moreover, it provides future business opportunities due to its general approach for diagnose further pathogens e.g. HPV or tuberculosis.Within the project, FRIZ aims to identify end-users for validation, discuss the handling and identify possible variations to enhance the usability and acceptance of the new system in phase 2. To find an appropriate partner for validation is also part of this feasibility study. In additio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Rapid Sheet Metal Product Development Chain by Laser Sintered Proto type Tools' (1994-1998).

assistant: **Concept**

The overall aim of the proposed project is a significant reduction of the time and costs involved in the development of sheet metal forming parts, by the application of laser sintered functional prototyping deep drawing tools and dies.The laser sintering technique will be further enhanced by an improved process control and the application of newly developed materials. This laser sintering process will then be applied for the direct manufacturing of functional tool sets. These tool sets will provide the basis to develop an industry ready rapid metal forming product development chain which covers the entire development process of metal forming products.The first sequence of the development process is the CAD design of the prototyping tool set. To support the designer, the CAD system has a knowledge base with rules for the design of elements creatable by laser sintering. This tool set will be manufactured by the enhanced laser sintering process and be compared to a conventionally manufactured reference tool set. Based on these practical tests, a set of guidelines will be composed, describing the needs for the implementation of the investigated rapid product development chain in an industrial environment.The results should lead to an improved and enlarged applicability of this technology in the short term thereby significantly enhancing the competitiveness of the industrial sector employing prototypes in their design process. In the long term, it can be speculated that fabrication by laser sintering may become a segment of the modern day machine tool industry.