RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Comparative Proteomics and Function of Secreted Proteins of Campylobacter jejuni'.

assistant: **Concept**

Bacterial pathogens often secrete proteins into their environment to institute infection of eukaryotic host cells. Common virulence-associated protein secretion machineries are the well studied type III and IV systems that facilitate proteins to associate with and translocate into eukaryotic cells. The principal bacterial food-borne pathogen Campylobacter jejuni and related species lack these systems but seem to have evolved alternative protein secretion strategies. So far, a few Campylobacter virulence-associated proteins have been identified. Most of these proteins appear to be secreted by the flagellar export system, some in response to host factors. The mechanism of this novel host-induced protein secretion pathway and the function of the secreted proteins, are unknown. The goal of this project is to dissect the mechanism(s) and function in cellular infection of Campylobacter protein secretion. More specifically, it is aimed: 1) to identify Campylobacter proteins and their secretion routes using a subproteome approach; 2) to decipher the regulation of host-induced bacterial protein secretion and their role in cellular infection using defined mutants, tagged recombinant proteins, and multiphoton confocal microscopy, and 3) to unravel the function of selected secreted proteins in host cell infection. This work is expected to expand our knowledge of host-pathogen interactions and to lead to the discovery of the control and function in cellular infection of bacterial protein secretion systems distinct from the classical type III and IV secretion machineries. The results may thus provide novel targets for vaccine and drug development against bacterial pathogens.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'In depth characterization of bio-mimetic lipid membrane structures generated by dip-pen nanolithography' to be submitted under Seventh Framework.

assistant: **Abstract**

Dip-pen nanolithography with lipids (L-DPN) has become a unique tool for the fabrication of structured lipid membranes. Biological membranes are heterogeneous structures composed of a combination of lipids, which gives the membrane its two-dimensional structure and fluidity, and proteins, which provide the membrane diverse biological functions. DPN uses the tip of an atomic force microscope to directly deposit, by physisorption,  the phospholipid ink onto a substrate. Depending on the surface wetting properties, the phospholipid ink tends to stack three dimensionally on the surface or rather spreads to form thin homogeneous membranes. In addition, the phospholipid ink may contain admixings of different functionalized lipids, so that e.g. proteins tagged accordingly can be selectively bound to the lipid patterns. This results in fluid, multivalent biomimetic-patterned membrane systems that are suitable model systems to study biological processes.An outstanding challenge in L-DPN is to monitor and elucidate the whole process from writing and self-organization in air to the reorganization of the stacks under water in details. Special attention should be paid to phase separation phenomena: it is still an open question, whether ink mixtures get transferred in equal proportions from tip to substrate and whether an homogeneously distribution of admixing can be generally assumed within the generated structures.The aim of the proposed project is a detailed study and characterization of all processes involved in the generation and details on the organization of  bio-mimetic phospholipid membrane stacks generated by DPN. Within this aim, the patterning behaviour of phospholipids in L-DPN will be studied systematically, a structural model of membrane stacks generated by L-DPN will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Analysis of eye vergence responses for the early detection and monitoring of cognitive and mental disorders' (MindTrack) targeting Horizon 2020.

assistant: **Abstract**

Cognitive and mental disorders such as Dementia, Alzheimer´s, depression and Parkinson's disease, some of them closely related to ageing populations, have high social and economic burden. Nowadays, neurologists, psychiatrists, psychologists, gerontologists and general practitioners rely on subjective, time-consuming semi-structured interviews and their knowledge and expertise to detect cognitive and mental disorders. Braingaze presents MindTrack, an unique, patented observer-independent support tool for the early detection and treatment monitoring of these disorders based on the analysis of small, involuntary eye movements (cognitive vergence). Our solution includes our own biometric software platform with interactive games designed to capture eye-related information and a remote cloud server for data interpretation thanks to the AI algorithms. MindTrack technology which falls into the Healthcare Information Technology market, has been already validated for ADHD and dyslexia detection (92% accuracy) and treatment with leading hospitals across Europe and now we want to develop a new marketable tool for the early detection, objective diagnosis and treatment monitoring of these other cognitive and mental disorders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integration of female immigrants in labour market and society. Policy assessment and policy recommendations' (FEMIPOL) under Sixth Framework.

assistant: **Objectives**

This study will explore and analyse the impact of integration policies, national and EU, on the position of migrant women within EU countries in the last decade, and on this basis will formulate recommendations for appropriate policy that fosters their integration and produces greater social cohesion. The focus will be on social integration processes understood as participation, access and belonging. A central assumption is that integration policies should attend to the agency of the persons involved. The analysis of the integration processes will therefore focus not only on barriers for social integration and on their removal, but also on the migration strategies and life plans of the female migrants. The project employs a four stage analysis: first , analyzing policies affecting the integration of female migrants, second, analyzing the migration flows as well as the demand for the labour of female migrants, third, analyzing integration processes in relation to female migrants and fourth, analyzing processes relating to the implementation of social policies. The project will employ a combination of methods. Statistical quantitative methods will be used to outline the character and forms of migration, employment and stay. However, a biographically based and agency-sensitive evaluation will be at the core of the analysis. On the basis of this agency-sensitive biographical evaluation of policy, the project will formulate recommendations for better policies both on the national and EU level aimed at the integration of female migrants in a socially cohesive manner. The analysis will cover 11 national cases that comprise typical cases in relation to migration policy (higly regulated versus unregulated immigration), in relation to welfare systems (North versus South European
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Fishing for Medicines and their targets using Zebrafish models of human diseases' (FISHMED), addressing dissemination and exploitation.

assistant: **Impact**

The International Institute of Molecular and Cell Biology (IIMCB) was created with the support of UNESCO, Polish Academy of Sciences (PAN) and the Polish Government and started its activity in 1999. The Institute is a unique, innovative, based on the best world standards research centre, known for it’s scientific excellence. In 2010, IIMCB was ranked first among 36 biological institutions in Poland.However, our aim is to position us at a level of excellence comparable to the best European entities.To achieve this goal, we plan to create the FishMed Centre to be the first zebrafish research and breeding facility in Poland. Zebrafish is an excellent organism to study various aspects of human disease because it is fully transparent until adulthood, and its metabolism is similar to that of mammals. The FishMed Centre proposal has five objectives that can be achieved, documented, and verified. The first objective is the twinning of seven IIMCB groups with six excellent European zebrafish centres. These include the Max Planck Institute for Heart and Lung Research in Bad Nauheim, the Universities of Cambridge, Leiden, Sheffield, and Geneva, and an Austrian Institute of Science and Technology. The twinning Partners will share their zebrafish models and know-how in joint projects with regard to cancer, neurodegeneration, epigenetics, and tissue regeneration. The second objective is to develop a zebrafish breeding facility and organize a new research group headed by a leader selected in an international competition. The third objective is to upgrade equipment. The last two objectives are to increase the innovation potential of IIMCB through reinforcement of the technology transfer unit and create a visibility platform to interact with scientific and non-scientific communities.Tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Neurogenesis-related changes in hippocampal new neurons and circuits after traumatic brain injury' under Horizon 2020.

assistant: **Concept**

Traumatic brain injury (TBI) affects millions of people representing a major public health concern, however, treatment options are limited. Even after mild TBI many individuals suffer from long term neuropsychological impairments such as memory loss and learning deficits. We hypothesize that some of the observed impairments are related to the alterations in adult hippocampal neurogenesis (AHN), the life-long capability of the hippocampus to generate new neurons from neural stem cells (NSCs). Alterations in AHN lead in turn to modifications of neuronal circuits and behavior. The hippocampus is essential for learning, memory consolidation and mood control and is highly vulnerable to TBI. We propose that the population of NSCs and the process of AHN is significantly altered, which might account for some of the symptoms associated with TBI. We hypothesize that TBI induces long term changes in, both NSCs and in differentiating neurons (inducing “aberrant” neurogenesis). As a result the electrophysiological properties of newborn and preexistent neurons in the hippocampal circuitry are changed, altering brain functioning. Proposed research is aimed at examining on how altered NSCs and “aberrant” neurogenesis impacts hippocampal neuronal activity after TBI. In proposed study we will combine neuron activity modification, quantitative neuroimaging anlysis and intracellular patch-clamp recordings in order to evaluate the effects of TBI on NSC proliferation, immature neuron number, and electrophysiological properties of post – TBI born neurons once they fully mature. We believe that the proposed research will contribute to better understanding the pathophysiology of TBI and that has the potential to help develop novel therapeutic strategies, targeting NSCs and newborn neurons, to i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Circularly Polarized Antenna Arrays for Broadband Satellite Data Terminals Using Substrate Integrated Waveguides enhanced with Metamaterials' (SIW-SAT-ANTENNAS).

assistant: **Innovation**

There is a currently increasing interest for broadband mobile satellite communications that can fulfil the Digital Agenda 2020 objective for fast Internet everywhere. Furthermore,European regulators have recently agreed to harmonize the spectrum for Earth Stations on Mobile Platforms that will use parts of the Ka-Band (17-30 GHz). Operators such as Inmarsat are planning to launch Ka-Band broadband satellite data services. New antennas and related components are required for the mobile terminals. It is proposed that broadband and miniaturized Circularly Polarized (CP) Antenna Arrays Using Substrate Integrated Waveguides(SIW) enhanced with metamaterials will be developed. SIW is a progressively important technology for millimeter waves and metamaterials (artificially macroscopic structures that mimic materials) have been transforming many wireless system components.  Few papers have reported SIW CP antenna arrays and no compact flat antenna designs have yet been published for such applications. Antenna arrays with at least 8x8 elements are expected to satisfy link budget requirements. A synthetic approach is proposed that combines SIW with metamaterials for miniaturization and broadbanding. Moreover, evolutionary algorithms are exploited for efficient array geometry optimization in order to reach the desired broadband performance. Complementary circuit components will also be investigated; waveguide transitions and couplers that affect the size of the feeding network and consequently the array size. The innovative antennas coming out of this project can contribute to a competitive advantage for European industry and have an impact on the adoption of broadband mobile satellite Internet. The IPR potential is significant and offers future research opportunities on antennas f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Consequences of Demographic Change' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The project will be using the Gender and Generations Surveys (GGS) – a system of comparable micro-level surveys for several Developed countries – to analyse the consequences of demographic change. The analysis will be using households and individuals as the unit of observation. As a result, we will be able to make inferences about how certain demographic behaviours (i.e. childbearing, marital disruption, single motherhood, leaving home), including their timing and sequencing, affect certain outcomes, such as income, poverty, deprivation, together with various child outcomes. This analysis is particularly relevant given recent demographic trends in developed countries (e.g. divorce rates are increasing, out-of-wedlock childbearing is becoming more prevalent, and general delay in key demographic events such as childbearing and leaving the parental home). The novelty of the study is driven by its focus on consequences of newly emerging demographic patterns and behaviour, which is in contrast to the majority of previous demographic studies – which has tended to focus on the determinants behind these trends. Policy analysis has not had a strong tradition in Demography and the aim of this project is to rectify this shortcoming of the discipline. By focusing on the consequences of demographic change and using techniques that are borrowed from program evaluation, econometrics, applied statistics and empirical sociology, we aim to advance the understanding of how demographic events impact other important processes in the life course of individuals and how policy makers can best influence such outcomes by appropriate policy interventions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Phototrophic biofilms and their potential applications: towards the development of a unifying concept'.

assistant: **Concept**

Phototrophic biofilms are communities, driven by photosynthesing microorganisms, and occurring on interfaces in terrestrial and aquatic environments. Such biofilms cause biofouling on e.g. submersed objects and monuments, but also have a great bioremediation potential for water and soils. PHOBIA proposes to grow air-exposed and aquatic phototrophic biofilms on soft and hard substrata in a specially designed incubator, in which microenvironment, architecture, growth, and biodiversity on the biofilm communities will be analysed, and in which their major physiological processes will be quantified. In contrast to heterotrophic biofilms, predictive models are not available for phototrophic biofilms. Our objective is to develop a unifying model of a phototrophic biofilm, and to use that for management and control of phototrophic biofilms in existing and new applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The aging germ cell – biological pathways, risk factors and mechanisms underlying an increasing medical and socio-economic problem'.

assistant: **Objectives**

The main objective of GermAge is to understand the devastating decline in germ cell quality during aging, and thus to define the determinants, pathways and risk factors for age-dependent infertility, aneuploidy and inherited diseases. The aging population and the dramatically increasing age of parenthood are associated with grave medical problems, declining reproductive health, and severe consequences for the socio-economic well-being of our societies. These proboems will impact the demographic structure and societal welfare in the European population. Thus the urgent need to understand the biological basis and to identify risk factors and pathways of the steep age-dependent decline in female and male germ cell quality. GermAge will address mostly the aging female gametogenesis known to be most severely affected by aging, but also the important contribution of aging male germ cells to age-related fertility and inheritance problems. The decay of key chromosome proteins such as cohesins, the failure of quality control mechanisms such as the spindle assembly checkpoint, and the mutation load in aging spermatogonial stem cells are among the highly synergetic research topics of GermAge. Mouse and human germ cells will be analyzed by high-end and innovative techniques. The expected insights will eventually lead to much improved diagnostics in various reproductive medicine procedures such as quality control of germ cells frozen for delayed in vitro fertilization, development of new biomarkers for oocytes, risk assessment for inherited diseases including aneuploidie in carriers of specific mutations, and prognosis based on individualized genomics on age-related quality decline of oocytes and spermatocytes. We also expect that our findings will raise awareness of the risks assoc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Automated Linear Parameter-Varying Modeling and Control Synthesis for Nonlinear Complex Systems'.

assistant: **Concept**

Linear Parameter-Varying (LPV) systems are flexible mathematical models capable of representing Nonlinear (NL)/Time-Varying (TV) dynamical behaviors of complex physical systems (e.g., wafer scanners, car engines, chemical reactors), often encountered in engineering, via a linear structure. The LPV framework provides computationally efficient and robust approaches to synthesize digital controllers that can ensure desired operation of such systems - making it attractive to (i) high-tech mechatronic, (ii) automotive and (iii) chemical-process applications. Such a framework is important to meet with the increasing operational demands of systems in these industrial sectors and to realize future technological targets. However, recent studies have shown that, to fully exploit the potential of the LPV framework, a number of limiting factors of the underlying theory ask a for serious innovation, as currently it is not understood how to (1) automate exact and low-complexity LPV modeling of real-world applications and how to refine uncertain aspects of these models efficiently by the help of measured data, (2) incorporate control objectives directly into modeling and to develop model reduction approaches for control, and (3) how to see modeling & control synthesis as a unified, closed-loop system synthesis approach directly oriented for the underlying NL/TV system. Furthermore, due to the increasingly cyber-physical nature of applications, (4) control synthesis is needed in a plug & play fashion, where if sub-systems are modified or exchanged, then the control design and the model of the whole system are only incrementally updated. This project aims to surmount Challenges (1)-(4) by establishing an innovative revolution of the LPV framework supported by a software suite and extens