RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Three-Dimensional Multilayered Epithelial Morphodynamics'.

assistant: **Concept**

How the organismal morphology is specified, maintained, and evolving is an intriguing open question of developmental biology and biophysics. In this proposal, I aim to unravel the physical mechanisms underlying the three-dimensional (3D) morphodynamics of epithelium. Drosophila wing disc is a good model organism for this problem because it undergoes complex 3D morphogenetic processes from larval to pupal stage which are highly related to gene expression, hormone level, cell active behaviors, and mechanical forces.  The correct sequential folding, unfolding, and eversion of wing disc have been observed as exquisite and elaborated processes while the underlying physical mechanism is still unclear. We will establish a biomechanical theoretical framework with a novel hybrid vertex-continuum model, and develop advanced numerical simulation methods to mimic wing disc three-dimensional morphodynamics. A morphometric analysis method and statistical quantifications will be developed and applied, for the first time, to quantitatively compare the simulation and experiments performed by my collaborators.


**Keywords:** Three-dimensional morphogenesis; biomechanical modeling; cell-ECM interaction; ECM remodeling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'INNOVATION AND IMPROVEMENT OF EUROPEAN WINE INDUSTRY COMPETITIVENESS BY THE RESEARCH AND DEVELOPMENT OF NATIVE MICROENCAPSULATED WINE YEASTS TO PRODUCE QUALITY WINES' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Europe is the home of wine and the world´s leading producer. The quality wine producing is the basis of the economy of more than 2,4 millions of winegrowers that work in the vines that cover around 3,6 million hectares in Europe. In fact, the wine production represents the 5% of the value of agricultural output. But the fact is that the European wine SMEs are rapidly losing market share to dynamic and large wineproducers from the New World. Imports are increasing rapidly and exports are growing slowly.  Over the centuries, the European oenology has accumulated numerous pragmatic acts, which, in fact, do not correspond to an actual point of view. To be competitive the SMEs participants know that further research is needed to optimize the fermentation variables and therefore to produce a more competitive wine focused on the current consumer taste.  Only with this scientific approach done by the RTDs, the SMEs involved will be able to achieve their competitiveness in wine industry applying some of the newer advances in fermentation technology. The use of microencapsulated, autochthonous and selected starter cultures will allow the SMEs to control the whole fermentation process and a uniform production of the highest quality wine through successive processes and seasons. The strains will be isolated in the vineyards of the different European wine regions and selected with the direction of the SMEs who will choose the final strains in function of their influence on the organoleptic characteristics of the final wine and of their ability to conduct and to finish the alcoholic fermentation correctly.  The development of this project will confirm the common effort that the European wine SMEs are making to defend the wine quality even over the interest of each wine region industr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High resolution nmr analysis of platelet lipids and their function' in the context of a Fourth Framework call.

assistant: **Objectives**

Of the 50 or more structurally distinct phospholipids present in platelets only a few have been quantitatively analysed or shown to participate in cell signalling or other platelet functions. Many lipids can now be analysed by GC-MS and LC-MS and one and 2D-NMR lipid (and cytosolic) profiles have been analysed for all classes of phospholipids. These two complementary approaches will be utilised to elucidate the role of specific lipids and lipid moieties in cell signalling and in the morphological changes induced by agonists and antagonists like collagen, thrombin, PAF, NO etc. Comparison of the profiles from resting and stimulated platelets, when carried out in a time-and-dose-dependent manner, should correlate with shape change, aggregation, exocytosis-degranulation, PAF and eicosanoid formation by different phospholipases A2, C and D. Comparison of the platelet lipid profiles from healthy and diseased volunteers will be used to correlate changes in specific with the severity of platelet associated diseases such as thrombosis, hyperlipidemias, etc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of Economic One-Step Flue -Gas Cleaning Technology for Small Combustion Units' under Fourth Framework.

assistant: **Concept**

There are a lot of small and middle sized combustion units covering a broad spectrum of firing systems and input materials in Europe. All these firing systems cause emissions, such as dust, organic and inorganic substances as well as odorous gases. However, most of them do not have any off gas treatment or just have a device to remove coarse dust particles, such as an electrostatic precipitator (ESP) or a cyclone. The major disadvantage of these  offgases but do not affect the gaseous portion of the emissions. On the other hand, highly sophisticated systems with multistage scrubbers, active carbon injection/coke beds, fabric filters and catalysts as applied in municipal solid waste incineration in countries with strict limit values such as Germany (17th BlmSchV, TA Luft ), the Netherlands, Austria or Sweden, and as being asked in the EU draft to limit dioxin emissions from waste incinerators (EU 1994) are too cost intensive for smaller installations. The project proposal Development of Economic One Step Flue Gas Cleaning Technology for Small Combustion Unit (EOS Gas Cleaning) is a joint effort by various industries and a research organisation to develop a new reactor which can be used to remove dust, inorganic (except NOx), organic and odorous substances from combustion gases in one step. The reactor consists of an optimised moving bed filter technology combined with a granulated sorption material. The sorption material is a further development (modification) of Sorbalit(c) (lime based mixture with additives). In future, a compact one step flue gas cleaning system will be available to operate a variety of small and middle sized combustion units in compliance with legal requirements. As a robust system, such technology will allow for easy handling and guarantee safe oper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The trade-off between longevity and reproduction: optimal control of aging'.

assistant: **Objectives**

The lifespan of genetically identical organisms varies depending on the environment they are exposed to. A well-known example is the extension of lifespan by nutrient restriction, as observed in animals as diverse as nematodes and rhesus monkeys. Why does the lifespan of animals change with environmental conditions? Is there an advantage to living longer when food is poor, and to living shorter when food is plentiful?Evolutionary theory, known as the disposable soma theory (DST), proposes that organisms age due to the accumulation of damage. According to theory, aging can be delayed by continuous damage repair, but such repair requires resources which are then unavailable for other tasks, such as reproduction. The DST therefore postulates a trade-off between longevity and reproduction dictated by the limitation of available resources. The optimal allocation of resources to self-maintenance depends on the environment. In particular, increased allocation to self-maintenance is predicted to maximize fitness when nutrients are scarce.Combining theory and experiment, I will investigate how the optimal allocation of resources to self-maintenance depends on nutrient availability using the nematode C. elegans as a model system. I will quantify the partitioning of resources between self-maintenance and reproduction using isotope labelling and kinetic modelling, and modulate resource allocation using available genetic alleles and directed mutation. Employing a competitive growth assay, I will test if fitness depends on resource allocation by an inverse U-shaped function, as predicted by theory and examine how the optimal resource allocation depends on nutrient availability. I will thereby assess if worms adapt their rate of aging to maximize their fitness in different environment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'COsts and Mechanisms of Personalised Exercise and Education for chronic Low back pain' (COMPEL).

assistant: **Innovation**

Back pain is the leading cause of disability in Europe. Chronic low back pain (CLBP) is the most costly and burdensome form. As the EU population ages, there is an urgent need for more clinically and cost-effective therapies to ensure sustainable healthcare. Dr O’Keeffe will explore a personalised medicine approach to exercise and education for CLBP. This is cutting edge, and has shown promising results beyond other therapies. Dr O’Keeffe is the perfect match for this project, as she has led a trial on this novel therapy for her PhD. This will be the first project to examine the mechanisms, response, and the cost-effectiveness of personalised exercise and education for CLBP. This will build on Dr O’Keeffe’s experience to expand and develop her skills in this area. Dr O’Keeffe will be trained in mediation, moderation and economic evaluation. She will gain additional research skills in new study designs, research software, physical activity measurement, gender analysis and public patient involvement. She will gain transferable skills in communication and public engagement, interdisciplinary networking, grantsmanship, project management, leadership and supervision. She will gain exposure to the non-academic sector through a secondment to a non-governmental organisation. Dr O’Keeffe will disseminate her results through open-access journals and conferences. She will communicate her results and Marie Sklodowska-Curie experience through social media, TV, radio and European Research events. If awarded this fellowship, Dr O’Keeffe will be equipped with the right skillset to improve her employability and reach a position of professional maturity. She will expand the European Research Area by strengthening networks. She will put Europe at the forefront of excellence and innovation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Circular DNA in diagnosis and disease models' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Many human diseases, including cancers and inflammatory disorders, are associated with the production of ‘circular DNA’ from chromosomes. These molecules have potential as biomarkers, and in the case of cancers are potential drivers of disease progression. However, the technology for detecting circular DNA and for creating disease models is lacking, meaning we cannot explore their potential use in diagnostics. CIRCULAR VISIONs goal is to explore the new opportunities circular DNA creates in early diagnosis and monitoring of disease, particularly screening, and to create an experimental system to understand the link between disease and circular DNA.CIRCULAR VISION will explore this brand new territory by creating highly sensitive whole genome screens for circular DNA that correlate with disease, using lung cancer (LC) and inflammatory bowel disease (IBD) as model examples. We develop and combine novel methods in molecular biology, microfluidics, DNA sequencing and bioinformatics in order to identify new diagnostic markers. Such markers for IBD and LC will then be adapted to clinical diagnosis and prognosis using advanced image analysis and cytometry methods. Finally, CIRCULAR VISION will show the causal link between circular DNA and cancer, by producing disease models with oncogenes on circular DNA.CIRCULAR VISION assembles key pioneers in the emerging field of circular DNA with leading clinical experts and key commercial players in cytometry and genomics. We are convinced that our technology has broad applications in early noninvasive diagnosis of cancer and monitoring of inflammatory diseases. We believe our technology will lay the foundation for future research into circular DNA biology and spur future drug development.


**Keywords:** Lung cancer, Circular DNA, eccDN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'THERANOSTICS ECOSYSTEM FOR PERSONALISED CARE'.

assistant: **Innovation**

Thera4Care represents a large unique consortium, gathering well-established European academic radiotheranostic centres, strong industry partners, European and medical societies focusing on training and education, a patient advocacy group spearheaded by an experienced project management group. Thera4Care aims to establish a European network of radiotheranostics centres able to rapidly develop and implement radiotheranostics tools and solutions to drive precision health. The overarching vision of Thera4Care is to revolutionise radiotheranostics procedures by establishing, implementing, and disseminating standardised scalable methods to produce and efficiently administer key radiotheranostics solutions. Thera4Care focus is on developing diagnostic and therapeutic ligands tailored to key disease areas (such as solid tumours), aligning with the growing significance of multi-modal radiotheranostics solutions dominated by radionuclide-based therapy and companion diagnostics. Thera4Care project is scheduled for 5 years and consists of 9 work packages. WP1 handles Project Management, WP2 focuses on Regulatory aspects, WP3 plans Preclinical studies, WP4 provides Supply chain, WP5 develops Clinical Trials, WP6 generates AI models, WP7 focuses on Dosimetry, WP8 develops Precision Imaging components, while WP9 focuses on Education and Dissemination.  Thera4Care will advocate for the progress of radiotheranostics, with the goal of increasing medical knowledge and enhancing treatment efficacy for improved patient outcomes. Concurrently, aims to coordinate scientific initiatives across European landscapes, leveraging a comprehensive and multimodal approach to cancer therapy applicable to various cancer types. Lastly, will work on the establishment of sustainable supply and production n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Pedagogical Distributed Group Care'.

assistant: **Objectives**

Ped-Care has introduced a work method that revitalises current pedagogical techniques, adapting them to the technological platforms used and correcting the deficiencies of said techniques due to the different time schedules and locations of teachers and students. Ped-Care has improved the communication processes between students and teachers and the management of the relationship with the learners (pedagogical CRM, Learner/Student Relationship Management) by introducing optimised processes. These processes have included e-mail management and other communication tools by means of intelligent managers able to classify, forward or automatically answer messages that are addressed daily to teachers.Methodology and tools contribute also to improve the process of monitoring students' activities during the course and evaluating them in the learning process being accessible through a wide range of mobile devices offering intuitive interfaces.LRM methodology is based on the assumption that pedagogy, technology and business are now inseparable in the new learning models. It proposes transference of CRM strategies and technologies to the education environment.The main aim is to increase the learner's real value for the organisation, that is, his capacity of learning, discarding any socio-economic consideration. LRM wants learners to learn more and better, reaching learner satisfaction through a better understanding of their needs. This business scenario has the risk of provoking the segregation of those students less interesting (from an economic point of view) for the organisations. For this reason, it is necessary to include pedagogical considerations in the traditional CRM approach (Learner Care).DESCRIPTION OF WORKSemantic analysis techniques have been developed in order to fil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ECO-design and manufacturing of thermoplastic structural fairings for helicopters' (ECO-Fairs), addressing dissemination and exploitation.

assistant: **Impact**

The project aims to design and manufacture three structural fairings for helicopters using thermoplastic composite materials, namely:-Upper Panel Rear Fuselage Demonstrator;-Sponson Fairing Demonstrator;-Radome Demonstrator.Materials and processes selection and technology guidelines will support the design phase in which tooling and process parameters will be designed and set-up. The three physical demonstrators will be produced and tested according to technical specifications, with a low environmental impact and with a TRL6 Technology Readiness Level. Resistance, induction and ultrasonic welding techniques will be studied in depth in the project for the manufacturing of the joinings required for the demonstrators assembling, and their use will be preferred to mechanical and bonded joinings, in order to decrease the extensive use of adhesives and mechanical fasteners and to make easier the recyclability at components end-life. In order to achieve the most economic design and manufacturing technologies, and in order to evaluate the mechanical performances and to achieve the eco-quotation of the demonstrators, a sound methodology will be used, together with reliable theoretical, numerical and technological instruments. The performances of the three demonstrators will be evaluated trough an extensive experimental campaign, starting from tests on coupons at different conditions up to the final tests on the demonstrators. Moreover the NDI plans for the demonstrators will be developed and executed, and the performances will be evaluated also through the eco-quotation of the components. At last all the actions required for the definition of the certification roadmap will be investigated and outlined.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Acid chromic recycling from rinse water in galvanic plants by electro-electrodialasis (RECY-CHROM)' (RECY-CHROM) under Fifth Framework.

assistant: **Objectives**

90% of chromium-plating facilities in Europe are SMEs, with all resources allocated to the daily work. The social and environmental concern related to the toxicity of the chromic acid used in the baths is leading the sector to a difficult decision; the investment in very complex and expensive systems to control and reduce the emissions could lead them to a non-competitive position. The basic objective of RECY-CHORM is to develop and validate a new system to recover chromium from the rinsing bath, using a clean technology such as electro-electrodialisis (EED) with 3 compartments, which does not need either water or chemical products to work. This system will be modular, portable and cheap to be affordable and valuable for SMEs. For this to be achieved, the consortium has been formed with partners skilled in different technologies involved (membranes, electrodialisis, raw material recovery and surface treatments), as well as planting industries to validate the results.