RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Signalling mechanisms of the class II isoforms of PI 3-kinase' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

PI 3-kinases (PI3Ks) generate intracellular lipid second messengers in signal transduction and membrane trafficking pathways. PI3Ks are implicated in cancer, inflammation and autoimmunity, and represent attractive drug targets. Mammalian PI3K isoforms are divided into class I, II and III PI3Ks. While the class I PI3Ks have been extensively studied and targeted in drug development, the other PI3Ks, especially the class II PI3Ks, remain poorly investigated.In this proposal, I aim to uncover the signalling mechanisms and functions of the class II PI3K isoforms, PI3K-C2alpha and PI3K-C2beta, by exploiting cells derived from unique gene-targeted mice generated in the Host Laboratory (unpublished) combined with my expertise in intracellular trafficking and imaging studies. Initial characterisation of these mice indicates that these PI3Ks could be drug targets in their own right in cancer and metabolism, observations that this project now seeks to understand at a molecular and cell level.By screening responses in cells in which class II PI3K isoforms are genetically inactivated in a ‘drug-like’ fashion, I will assess the coupling of these PI3Ks to distinct receptors and their functional impact, interrogate their downstream signalling pathways by phosphoproteomics and lipidomics, and perform a detailed assessment of their spatio-temporal activity upon activation of cell-surface receptors, in order to elucidate their sites of action and the precise subcellular events they regulate. Class II PI3K effector/complexes will be identified. It is poised to unravel new molecular mechanisms interlinking signalling and trafficking.I will bring expertise currently not available in the Host Laboratory and deliver a cross-disciplinary approach to uncover the mechanisms of action and function
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Targeting bicarbonate transport as a “first-in-class” therapeutic strategy to promote CD8+ T cell fitness and enhance cancer immunotherapy'.

assistant: **Concept**

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancer types. It is virtually resistant to any sort of therapy, including the most recent immunotherapies. These tumors are characterized by a strong hypoxic, nutrient poor, and acidic tumor microenvironment (TME), in which cytotoxic CD8+ T cells are excluded or absent. In the context of tumor acidity, the role of bicarbonate transporters, key regulators of pH homeostasis, has mostly been neglected so far. Supported by the ERC consolidator grant ImmunoFit, we recently unveiled that the metabolic editing of the TME via inhibition of a specific bicarbonate transporter in cancer cells represent a novel robust therapeutic strategy to mitigate the acidity of the TME, increase the fitness of CD8+ T cells, and render more effective the current immunotherapeutic regimens in pancreatic cancer.  To progress on the path from ground-breaking research towards innovation we now propose to de-risk the target by delivering early lead compounds (i.e., blockers) with proven therapeutic efficacy and synergism with immunotherapies in several preclinical tumor models, to be valorized for add-on cancer therapy through follow-up R&D collaborations and/or licensing agreements with Pharmaceutical & Biotech companies. This will lead to the commercialization of our sciences and broad societal impact with the deliverable of a brand-new therapeutic approach and combination regimens which are urgently required to tackle tumor resistance or refractoriness vis-à-vis immunotherapies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Alliance for Research on Cultural Heritage in Europe'.

assistant: **Objectives**

The Cultural Heritage (CH) Research and Innovation (R&I) landscape has changed significantly over the past few years. New political, technological and socio-economic parameters put emphasis on improving protection, conservation and restoration efficiency of European CH with green technologies, as well as developing and further exploiting high quality digitisation, open access and curation of digital assets. The need also exists to enhance the innovation potential and competitive edge of the Cultural and Creative Sector (CCS) to drive sustainable growth and job creation against global competition.Responding to these challenges, the project will develop a pan European framework for a holistic approach to CH R&I, by creating the Alliance for Research on Cultural Heritage in Europe (ARCHE), a spearheading coordination network of researchers, innovators, heritage professionals, institutional bodies and citizens. The objective is to engage all CH actors in member States / Associated Countries in the co-design of R&I strategies and roadmaps that lead to R&I initiatives requiring multidisciplinary approaches and skillsA detailed assessment of R&I gaps and needs for the next decade will be the basis for designing a Strategic Research and Innovation Agenda (SRIA) for joint programming aiming to increase awareness of heritage and European sense of belonging. A new purpose-built governance structure will be proposed that will effectively involve existing networks and new partners from relevant scientific disciplines and industries. It will also promote intensive and wide-ranging collaboration between cultural heritage, the arts, and the CCS. The SRIA and governance structure will be tested in a pilot operation in the third and final year.ARCHE will be a strong basis for a European
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Developing Intercropping for agrifood Value chains and Ecosystem Services delivery in Europe and Southern countries' under Horizon Europe.

assistant: **Concept**

IntercropValueES aims to exploit benefits of intercropping to design and manage productive, diversified, resilient, profitable, environmentally friendly cropping systems acceptable to farmers and actors in the agri-food chain. It will develop both a scientific research action for better understanding and modelling intimate intercrop functioning and a detailed analysis of lock-ins and levers at the value chain level to identify credible solutions that can be adopted by farmers and value chain actors. As a multi-disciplinary and multi-actor project, it brings together scientists and local actors representing food value chain. It includes 27 participants from 15 countries (3 continents) from a wide diversity of organizations and stakeholders. IntercropValuES organizes its activities in 6 objectives, to: 1) support the design of locally relevant, legitimate and innovative agri-food chains, through 13 Co-Innovation Case Studies; 2) understand the functioning and G*G*E*M interactions allowing the selection of compatible ideotypes and the optimization of machinery and management strategies for maximizing the productivity and delivery of ecosystem services with better soil health and mitigation of GHG (meta experiment 15 sites); 3) produce novel information, improved methods and tools for intercrop management and the assessment of their performance and profitability; 4) unravel intercropping performance by modelling; 5) analyze grain and sanitary quality of cereal-legume intercrops, functional qualities for food processing and new products, 6) uncover key barriers and levers at the value chain level to boost development, and identify new market avenues and solutions to increase economic added-value of intercrops. The Comms and Dissemination Plan is designed to diffuse outcomes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The role of Base molecules in AErosol formation'.

assistant: **Concept**

Aerosol formation and growth mechanisms need to be better understood to improve air quality and weather prediction models, and reduce uncertainty of radiative forcing in climate change projections. Globally, half of the aerosol population is formed via gas-to-particle conversion and the fraction exceeds 90% in high latitudes. In many locations, the initial molecular cluster forms from sulphuric acid and ammonia or dimethylamine. Growth to an aerosol particle is often explained by the condensation of sulphuric acid, methanesulfonic acid and highly oxygenated organic compounds. While the roles of strong acids and organic compounds and their oxidation channels are quantified in laboratory and field studies, cation detection and neutral atmospheric base measurements are notably under-represented. An important innovation of this project will be the direct measurement of cations and neutral base molecules and clusters based on mass spectrometry. Ammonia, a base predominantly emitted by agriculture, is a key air pollutant in the formation of fine particulate matter (PM2.5). In western Europe, up to half of PM2.5 is attributed to ammonia pollution because of its ability to form aerosols in reactions with common atmospheric acids. Current atmospheric models do not include amines, which can form aerosol particles at a 1000-times faster rate than ammonia. To uncover the composition and level of toxicity of PM2.5, as well as the scattering and absorption of sunlight by aerosol particles, it is critical to understand the atmospheric chemistry and molecular pathways that control their formation and growth. The project will focus on the role of base molecules in the formation of new particles and their fate in the atmosphere and is led by an established PI with a demonstrated history
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CARBON-NEGATIVE CEMENT: A TRIBOLOGICAL SOLUTION FOR LIMESTONE DECARBONATION, SILICATION AND CARBON UTILIZATION' (CILANTRO).

assistant: **Concept**

The CILANTRO technology offers a groundbreaking solution to reducing the carbon footprint associated with traditional cement production. CILANTRO introduces non-thermal, Direct Tribochemical Hydrogenolysis (DTCH) of calcium carbonate with silica yielding no CO2 emission and producing solid (CaO)nSiO2 (where n = 1,2,3) - the essential component of Ordinary Portland Cement. This innovative approach significantly deviates from current practices by bypassing the high-temperature steps of the conventional production process, which are fueled by fossil fuels, such as limestone calcination and clinkerization. It also co-produce CO which is the resource of synthetic fuels and offers another benefit to reducing carbon footprint. The key DTCH reaction design utilizes free-radical intermediates generated by rubbing/shearing of limestone and sand without heating, followed by in situ reduction of carbonate with H2. To suppress the competitive reactions which can lead to undesired minor CO2 emission DTCH procedure and parameters will be analyzed by laboratory measurements and computer simulations at different levels. To carry out the DTCH at scale, CILANTRO aims to design a new well-controlled tribo-reactor having a mechanical principle similar to the existing comminution mills in cement plants. It is expected that CILANTRO technology can be easily scaled up and employed as a new asset. By using electricity and H2 from renewable sources, the whole cement production process can be carbon-neutral. Given the natural/accelerated carbonation of concrete fabricated from CILANTRO binders the cement can achieve significant net CO2 sink over the concrete lifecycle. CILANTRO is compatible with other approaches and processes addressed within the portfolio such as combination with supplementary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Analysis, modelling and sensing of both physiological and environmental factors for the customized and predictive self-management of Asthma' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

myAirCoach aims to develop a holistic mHealth personalised asthma monitoring system empowering patients to manage their own health by providing user friendly tools to increase the awareness of their clinical state and effectiveness of medical treatment. This will be achieved through a multi-disciplinary approach aiming at the development of an ergonomic, compact and efficient sensor-based inhaler that will be in continuous communication with a mobile device. This sensing infrastructure will have the capability of automated monitoring of several clinical, behavioural and environmental factors in realistic conditions. A pipeline of advanced analysis, processing and computational modelling techniques, dealing with raw measurements, extracted features, indicators, and personal profile data representation will ensure clinical state awareness and a timely optimal treatment. Besides, a ""personal mHealth guidance system"" will empower patients to customize their treatment towards personalised preset goals and guidelines, either automatically or driven by healthcare professional in a telemedicine manner. In this context, myAirCoach will give to clinicians early indications of increasing symptoms or exacerbations, while making an important contribution in successfully self-management of asthma. The myAirCoach framework will be quantified and evaluated in two test campaigns with carefully designed cohorts of patients in three testing sites. Besides the obvious necessity of the test campaigns to ground the myAirCoach patient models and framework with data, the objective formal validation of the results is expected to lead to increased confidence in the myAirCoach approach and in ICT decision support and self-management systems in general. The impact of such a holistic and innovati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Synapses: from molecules to higher brain function and diseases' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

SyMBaD aims to move forward our knowledge on synapse structure and function in the normal and pathological brain. Brain diseases represent a considerable social and economic burden in Europe. Emerging evidence indicates that synaptic dysfunction is associated with a majority of neurological and psychiatric disorders. Novel therapeutical approaches relie on a better knowledge of the synapse and its pathologies. The network comprises 23 teams from 6 academic centres (Bordeaux, Alicante, Milan, Geneva, Göttingen, Bristol) representing an important fraction of the leading European researchers in the field. Synergies and complementarities between the research teams exist and should develop with the activities of the SyMBaD network. The participants are already well integrated in European scientific collaborative networks, and have an outstanding track-record of training young researchers. Industrial partners (6) will take part as full partners in training by an obligatory placement from 6 to 12 months of 16 ESR among the 26 recruited. The other ESR will be fully integrated into collaborative projects between academic teams. The private sector comprises companies involved in the development of new therapeutical strategies to combat brain diseases (GSK, Neurosearch, Xygen, and Noscira) and companies involved in technical development to be used in synaptic research and beyond (Bioxtal, Amplitude Systems, Explora Nova). The SYMBAD network aims to: • Teach a number of increasingly sophisticated techniques required in neuroscience and to advance towards novel therapies. • Focus on technological innovation and on interweaving of multilevel approaches. • Facilitate future constructive dialogue between academia and industry in the field by involving SMEs in the training of PhD studen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Collective effect with ordered nanofiber-trapped atomic arrays as efficient light-matter interfaces'.

assistant: **Objectives**

Efficient interactions between photons and quantum emitters are at the heart of numerous quantum information devices, such as quantum memories, switches or gates. Using chains of individual cold atoms trapped close to an optical nanofiber, the goal of the proposed research is to exploit the enhanced linear and non-linear quantum interactions that can result from the unique features of such one-dimensional ordered arrays. Periodically arranged atomic structures indeed exhibit specific light scattering properties, i.e., Bragg reflection, super-, sub- and even selective radiance. The interaction of guided light with ordered arrays can lead to tailored functionalities unavailable in current light-matter interfaces. Novel and resource-efficient quantum memory and gate protocols will be targeted. This project will push this original light-atom array paradigm towards building blocks for future quantum technologies. The candidate, with a strong background in atomic physics, quantum optics, and nonlinear optics will exploit his expertise to develop the project while extending his skillset towards the implementation of quantum information networks and further developing his innovation and leadership abilities during the fellowship.


**Keywords:** nanofiber, cold atoms, nanophotonics, quantum memory, quantum networks
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Piezoceutical biomaterial scaffolds for immunomodulatory-based myocardial repair' (PiezoMac) targeting Horizon Europe.

assistant: **Abstract**

Cardiac injury in the form of a myocardial infarction leads to cardiac muscle death and replacement scar tissue that cannot compensate lost heart tissue. This disease does not improve with traditional drugs and places significant burden on healthcare budgets worldwide; with a reduced quality of life for patients, often leading to heart failure. Current engineered cardiac patches do not reduce inflammation and do not integrate in a sufficient manner to compensate the pumping power lost with the heart tissue.The PiezoMac patch differs fundamentally from patches reported up to now. It will contain an optimised piezoelectric capability that will yield electric fields generated by the stretching of the heart. This electric field stimulation will be optimised to drive immunomodulate and regeneration of the cardiac muscle.  The shape of the patch is predesigned using finite element modelling to conform the directional dependent stretching of the heart wall; with information of patient anatomy and extent of heart attack damage derived from X-ray CT and MRI scans. These smart patches will be 3D printed (using melt electrowriting) into accurate microfibrous ordered patches whose density, micro-orientation and fibre laydown will be informed using in silico modelling of piezoelectric generation and mechanical anisotropy. We will shortlist candidate mesh designs to match the anisotropy of the heart using finite element analysis, and refine the design process using a Bayesian Optimisation approach to strike a balance between mechanical anisotropy and piezoelectric output, and ultimately halt cardiac deterioration. This pragmatic and rational approach gathers and advances cutting-edge technologies in this interdisciplinary project to address a significant unmet need in healthcare toda