RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Genetic determinants promoting resistance to BCR-loss in B-cell lymphomas' to be submitted under Horizon 2020.

assistant: **Abstract**

Loss of B-Cell Receptor (BCR) in lymphoma B cells leads to attenuated PI3K/AKT signaling and altered Myc-dependent transcriptional output, resulting in a competitive disadvantage in BCR-deficient lymphoma cells. The acquisition of genetic events restoring signaling competence is sufficient to improve cellular fitness in BCR-deficient lymphomas. A fraction of Non-Hodgkin-B-cell lymphomas carry missense mutations in FOXO1, a transcription factor essential during B cell development, and a main target of the PI3K/AKT pathway, which relays survival signals downstream of the BCR. In preliminary studies, we found that cells with FOXO1 mutations rewire their signaling status showing a) activation of stress-activated protein kinases (SAPKs) and PI3K/AKT, b) altered responses to key upstream receptors, such as CD40 and BCR, and c) improved fitness. In this context, I propose to investigate whether FOXO1 mutations are able to provide resistance to BCR-loss in transformed B cells, by favoring the activation of PI3K/AKT, SAPK/JNK (and potentially other) signaling pathways. This hypothesis will be tested using mouse and human models that allow conditional deletion of the BCR in FOXO1 mutant B cells, determining whether expression of FOXO1 mutations is: a) sufficient to release normal B cells from BCR-dependency, and b) able to restore competitive fitness to BCR-deficient lymphomas.  Moreover, combining CRISPR/Cas9 and chemical screenings, I propose to identify novel factors sustaining the growth of lymphoma cells that lost BCR expression. Overall, this research proposal will address relevant, yet unanswered questions in the biology of B cell lymphomas, providing a better understanding into the complexity of signaling competence in normal and transformed B cells, and identifying novel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Leveraging Multiphase Flow and Physical Chemistry to Engineer the Next Generation of Flotation Processes' (FlotSim).

assistant: **Innovation**

FLSmidth (FLS) is a world leading manufacturer providing service and technology to extract base metals and critical raw materials by flotation processes. Flotation is extremely complex and today still barely understood, so that a lot of energy and resources are wasted. Based on a long-term collaboration, Technische Universität Dresden (TUD) and FLS propose the EID FlotSim to drastically improve the recovery rates of flotation by science-based development. Highly improved next generation flotation cells are mandatory to remain economically competitive and to respond to the massive desire of citizens for ecology-friendly mining. FlotSim addresses these societal challenges through its research and development as well as the recruitment and training of five early stage researchers. They will jointly investigate and model the flotation process with its complex interactions between valuable mineral particles, gas bubbles, and turbulent flow, addressing phenomena from the nanoscale to the scale of pilot machines. With FlotSim, FLS, TUD and seven associated non-academic partners join forces to integrate top-notch scientific expertise and computational know-how into an industry-driven network. FlotSim will jointly develop new sophisticated quantitative models of the relevant micro-processes and integrate them into a novel predictive simulation framework for the entire flotation process. The structured training approach provides a balanced mix of high-level scientific courses and transferable skills by the partners together with on-site application-focussed secondments in industry. Network events target further young innovators and the industrial and scientific public. FlotSim strives for sustained impact by a portfolio of IPRs such as patents, joint publications in leading journ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Water supply watershed planning and management: an integrated approach' (WADI), addressing dissemination and exploitation.

assistant: **Impact**

The WADI project will focus on the development of tools and methodologies that cane used to assist decision making in watershed management boards and water planning authorities having to determine where to locate new dams/reservoirs. The tools and methodologies will address the various elements related to reservoir identification (geographic location, water volume, infrastructure cost) given the watershed characteristics (water demand requirements, water resources, MNT, etc)in an integrated manner that considers socio-economic issues as well as environmental aspects related to flood and drought risks. In addition, WADI will develop advanced data processing tools for modelling and simulation related to floods, reservoir design, and optimisation of the complete planned network of a watershed. Field applications will be performed on pilot basins in Morocco and Lebanon.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Microsystems based visual prosthesis' in the context of a Fourth Framework call.

assistant: **Objectives**

The objectives of this microsystems project consist in designing an artificial eye driving, via an external visual processor, an implantable neurostimulator including a spiral cuff electrode wrapped around the optic nerve and a transcutaneous power and data RF link.This project aims at realising microsystems-based prototypes in the field of rehabilitation engineering, and at demonstrating the efficacy of a functional prototype of visual prosthesis interfaced with the optic nerve.Acting upon a peripheral and passive neural structure is an advantage in blindness rehabilitation, provided that safe and selective electrical activation of its fibres would be feasible. Partners of this proposal have already developed an already commercialised spiral cuff electrode (SCE1), and demonstrated its efficiency in selective fibers activation. They also acquired a specific experience in the design of implantable electronic devices, analogue and digital specific integrated circuits (ASIC's) and biologically inspired analogue VLSI circuits and artificial retinas.Beside their use in the planned visual prosthesis, some components will be designed for other applications such as the artificial retina for a non-invasive sensory substitution visual prosthesis, the neurostimulator in Ti housing for general rehabilitation purposes, the Ti packaging techniques with Pt into glass feedthroughs, the cuff electrode and the RF transcutaneous link for various biomedical implant applications.The overall strategy of the project is to reassemble, around the particular design of the visual prosthesis, all the required industrial know-how to realise active implanted devices. The positioning of the European industry in this emergent technology is of great importance for the future. This know-how incorporates
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mechanisms Underlying Treatment Responses in Psychosis' (MUTRIPS).

assistant: **Concept**

Psychotic symptoms (hallucinations and delusions) have been associated with a striatal hyperdopaminergic state.Less explored, but also implicated are functional abnormalities in cognitive control, particularly in the prefrontal cortex; and a functional and structural disconnectivity between this and other areas of the brain.Such a disconnectivity would explain the lack of coherent response to conventional treatment: antipsychotic drugs do not benefit between 20 and 45 per cent of people with schizophrenia.The aim of this project is twofold: firstly, to explore the neural mechanisms underling cognitive control and the level at which cognitive control dysfunction operates in treatment refractory psychosis.The second is to test the hypothesis that cognitive dysfunction in patients who have treatment-resistant psychosis is associated with a specific neural signature – and discover whether that neural signature can be used as a biomarker of treatment resistance. Such a biomarker would help personalise treatment decisions and make treatment regimes more effective. It would also aid the development of novel treatments (other complementary work is investigating medication that enhances frontal cortical function as well as non-invasive brain stimulation techniques such as transcranial direct cortical stimulation).The project involves two linked brain imaging studies.The first will establish the indicative biomarker using both structural and functional MRI scanning and tasks to assess cognitive control at different levels of complexity.The second study will establish the validity of the biomarker by following a cohort of first episode psychosis patients for two years to discover whether their actual outcome corresponds with the outcome predicted by the neural signature shown in M
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Phase-i and ii trials of the malaria pre-erythrocytic vaccine lsa-3 and refinement of measurable outcomes (EMLI)' (EMLI), addressing dissemination and exploitation.

assistant: **Impact**

This proposal is based on a decade of European-sponsored research, which led to the rational identification, characterization, and demonstration of protection in Chimpanzees by LSA3. It aims at testing, in phase-I and conditional phase-II trials, the protective effect demonstrated in the primate genetically 98,4% similar to humans. Besides safety and immunogenicity, it includes a unique approach to the understanding of critical mechanism of defence in the liver, aimed at improving surrogates to guide future vaccine development. Three novel vaccine delivery systems will be used: Lactococcus lactic recombinant protein in the new SBAS2 adjuvant from SB Bio, DKA immunisation with the Adventism Pasteur licensed Vocal vector, lip peptide immunisation without adjuvant, yet another recent European discovery. It is performed witch the expert guidance of he 2 leading vaccine industries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Movements, Migration and Emotion: East/West Mobility, Transnational Bonding, and Political Identities in Polish Activists' Biographies'.

assistant: **Innovation**

MIGREMOV (Movements, Migration and Emotion: East/West Mobility, Transnational Bonding, and Political Identities in Polish Activists' Biographies) is a qualitative research project aimed at studying the role of migration and transnational connections in building political identities and developing social movements. It focuses on the case of Polish activists from 3 movements: the lesbian, gay, bisexual, trans* and queer (LGBTQ) movement, the women’s/feminist movement and the Jewish movement. It uses the biographical method of collecting life stories, as well as a Life History Calendar to reconstruct these activists’ trajectories throughout the post-socialist period (1989 to the present). It concentrates on the interactions between the process of endorsing political identities and the experiences of East/West migration and of transnational affective ties such as friendships and erotic/amorous relationships across borders and nationalities.MIGREMOV raises crucial questions for both European societies and social sciences: How does moving physically and mentally between geo-political and cultural contexts influence the process of becoming and being an activist? Does activism create specific opportunities and paths toward transnational lives? How do national identities and political ones intersect, and transform over time, in such contexts? Special attention will be given to the role of emotions, for traveling between contexts and transnational bonding is as much of an emotional journey as activism itself. Therefore, the various emotions attached to places (Poland and abroad, East and West, city and countryside…) and periods (moments of changing places, stays abroad and returns to Poland, encounters with new friends or partners, moments of higher or lower level of activism, et
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Fluids in the Earth, reconstructing their composition through space and time'.

assistant: **Concept**

Earth is the blue planet", with over 70% of its surface covered in water and a further equivalent of up to 4 oceans in its interior. This abundance of water has a profound impact on the processes that shape our planet, as well as the development of the organisms that inhabit it. To understand this impact, it is necessary to know the properties and chemistry of the fluids involved. At present this information is largely unavailable. This project aims to develop mineral composition as a new tool to determine the composition of fluids using the systematic partitioning of elements between minerals and fluids. Whereas direct samples of fluids are rare, especially as age increases, the associated minerals are preserved. At present, this approach is limited because of a lack of mineral-fluid partition values at appropriate conditions. Moreover, partitioning depends strongly on the speciation of elements in the fluid and this is mostly unknown at elevated pressures and temperatures. In this project I will develop a model to predict element partitioning between minerals and fluids at elevated pressures and temperatures. I will use atomistic simulation techniques to model both the preference of an element to enter the mineral, and the element's speciation. Combined, this will allow me to determine the relative partition coefficients among elements and the changes therein with changing pressure, temperature and chemistry. I will combine this relative model with partitioning experiments to allow for quantitative modelling of fluids in subduction zones and mid-ocean ridges, which control element cycling between the Earth’s interior and surface. I will also reconstruct ocean chemistry back in time, especially for the early Earth where life developed. More generally, given the ubiquit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'MYB rearrangements in Adenoid Cystic Carcinoma: protagonists or secondary characters?'.

assistant: **Innovation**

Adenoid cystic carcinoma (ACC) is both a rare disease (limited scientific data and professional expertise) and a cancer (complex tumour biology and evasion of conventional therapies). Clinical behaviour differs depending on primary tumour site; salivary gland ACC has poorer prognosis than breast ACC. A majority of ACC harbour MYB rearrangements resulting from chromosomal translocations, with the fusion of MYB and NFIB or MYBL1 and NFIB being the most frequent. The role of translocations in tumourigenesis and whether cells from different primary sites respond differently has not been determined. Identification of specific cell types carrying the translocation and location within the tumour microenvironment might enable development of MYB target-therapies. Our main objective is to elucidate the function of MYB rearrangements in normal salivary and mammary gland cells and the expression of the novel fusion genes in salivary gland and breast ACC. Normal human cells will be transfected with MYB-NFIB and MYBL1-NFIB fusion transcripts and fusion negative, fusion positive and combinations of cells will be compared in terms of cell morphology, differentiation, proliferation, migration and invasion. 3D models, more closely mimicking an in vivo tumour, will be compared to monolayer cultures. In situ localisation of MYB-NFIB and MYBL1-NFIB in salivary gland and breast ACC will be assessed using a novel technology, BaseScope. This ambitious research project will determine the consequences of MYB rearrangements using state-of-the-art methods in molecular and cellular biology, genetic and tissue engineering and pathological anatomy. The project has clear translational potential with social, cultural and economic impacts. Transfer of results to other cancers harbouring MYB rearrangemen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'HIGH BANDWIDTH LONG DISTANCE UNCOMPRESSED AUDIO-VIDEO SIGNAL TRANSMISSION SYSTEM DEVELOPMENT' under Horizon 2020.

assistant: **Concept**

Professional computer graphics and video applications’ tendency is to improve display resolutions for desktop monitors, projectors and consumer TV sets. Today HD resolution is a de facto standard used in TV broadcasting and computer displays. The so-called Ultra HD 4K pixel resolution has just started to spread in the industry, and NHK Japan's national public broadcasting organization announced to use 8K video standard during 2020 Winter Olympic Games. Today there is no existing product that extends UHD 120Hz 3D video signal, or other “retina display” type computer video content in an uncompressed and low latency format. The current video standards (DisplayPort 1.2, HDMI 2.0 and SDI 6G) define copper cable based connectivity, but they are limited to a distance of a few meters. Our innovative 40Gbit optical extension helps to cope with this problem and deliver a complete solution for these clients for up to 10 km distance. It consists of (1) a fiber optical extension standard enabling UHD and UHD-2 signal extension without latency, (2) extension devices extending DisplayPort 1.2 video signals for up to 10 km distance, and (3) a 40 Gigabit matrix switcher platform.The most relevant demand comes from digital cinemas, mass-media, festivals, concerts, openings, broadcasting of special events (particularly sport), museums, interactive exhibitions, 3D projections etc. Additional targets are medical and industrial market segments. We, Lightware Ltd., are a leading manufacturer of DVI, HDMI and DisplayPort matrix switchers, signal extenders and accessories for the professional audio visual (A/V) market with a headcount of about 130 persons and an annual revenue of 10 million EUR. We plan to commercialize our new product through our offices and distributors in more than 40 countr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'High performance electronic systems design network' under Fourth Framework.

assistant: **Concept**

The specialised electronics business is a high technology endeavour where a unique and highly complex product must be designed and optimised while using sophisticated ESD and simulation tools, a long chain of suppliers, customers and silicon foundries and the many constraints of the global open market. The proposed project intends to implement on a small scale a distributed working environment, based on high performance networking infrastructure readily available, i.e. Primary Rate ISDN and ATM switching. The distributed environment will comprise of the main manufacturing facility, the suppliers chain and the various specialised design teams. The objective will be to demonstrate, on the basis of an existing design and production contract for a telecommunications product, the benefits associated with the use of HPN in the area of Electronic System Design. The project will use existing commercial or beta tools for distributed simulation, modelling and design, on a common ESD platform exploiting the ISDN services for European level connectivity and ATM services for current in-house and prospective broadband connectivity.