RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Artificial microtubules based on switchable cyclic peptides' in the context of a Horizon 2020 call.

assistant: **Objectives**

Naturally occurring living materials, for e.g. the cell cytoskeleton, consist of intricate supramolecular polymers whose self-assembly is controlled by high energy molecules such as guanosine triphosphate GTP. MiNaturally occurring living materials, such as the cell cytoskeleton, consist of intricate supramolecular polymers whose self-assembly is controlled by high energy molecules such as guanosine triphosphate GTP. Microtubules for example, are incredibly strong, but because they are chemically fueled by GTP, they can be built up or broken down at specific times and locations inside the cell. The tubules are in so-called non-equilibrium steady states, and are kept away from the thermodynamic equilibrium for extended periods of time. In the recent years, artificial supramolecular polymers have been made that are transiently out-of-equilibrium by addition of a single shot of chemical fuel, or for long times by continuous addition of fuel and removal of waste. The mechanical properties of the latter artificial systems are quite poor in comparison with real microtubules. The aim of this CYCLOTUBES project is to make artificial microtubules from cyclic peptides that can chemically or enzymatically be switched between the assembled and disassembled state. To this end, we will use oxidation and reduction reactions in a cell-like environment, that is, in a membrane enclosed chamber. In the latter, chemical fuel can be added and waste be removed continuously. In addition, the assembly/disassembly of the artificial tubules can be monitored using microscopy. Our work will give fundamentally new insights into out-of-equilibrium self-assembly, and could lead to novel life-like materials that are capable of performing significant mechanical work due to the unique mechanical propert
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Near-infrared fluorescent probes based on bacterial phytochromes for in vivo imaging' in the context of a Seventh Framework call.

assistant: **Objectives**

Non-invasive monitoring of deep-tissue developmental, metabolic and pathogenic processes will advance modern biology. Imaging of live mammals using fluorescent probes is more feasible within the near-infrared (NIR) transparency window (NIRW: 650-900 nm) where hemoglobin and melanin absorbance significantly decreases, and water absorbance is still low. The most red-shifted fluorescent proteins (FPs) of the GFP-like family exhibit fluorescence outside of the NIRW and suffer from low brightness and modest photostability. Natural bacterial phytochrome photoreceptors (BphPs) utilize low molecular weight biliverdin as a chromophore and provide many advantages over other chromophore binding proteins. First, unlike the chromophores of non-bacterial phytochromes, biliverdin is ubiquitous in mammals. This makes BphP applications in mammalian cells, tissues and mammals as easy as conventional GFP-like FPs, without supplying chromophore through an external solution. Second, BphPs exhibit NIR absorbance and fluorescence, which are red-shifted relative to that of any other phytochromes, and lie within the NIRW. This makes BphPs spectrally complementary to GFP-like FPs and available optogenetic tools. Third, independent domain architecture and conformational changes upon biliverdin photoisomerization make BphPs attractive templates to design various photoactivatable probes. Based on the analysis of the photochemistry and structural changes of BphPs we plan to develop three new types of the BphP-based probes. These include bright and spectrally resolvable permanently fluorescent NIRFPs, NIRFPs photoswitchable either irreversibly or repeatedly with non-phototoxic NIR light, and NIR reporters and biosensors. The resulting NIR probes will extend fluorescence imaging methods to deep-tissue
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Machine learning for decision making under uncertainty' (DECIDE).

assistant: **Innovation**

Many important decisions are taken under uncertainty since we do not know the development of various parameters. In particular the ongoing green transition requires large and urgent societal investments in new energy modes, infrastructure and technology. The decisions are spanning over a very long time-horizon, and there are large uncertainty towards energy prices, demand of energy, and production from renewable sources. Such problem can be described as two-stage stochastic optimization problems, where we first decide which facilities to establish, and then we have to schedule the production/transportation for a stochastic demand, using the given facilities. If the decision variables are discrete, such problems are extremely difficult to solve. In this project we will develop a new framework for investment decision making under uncertainty based on a combination of machine learning and operations research. Instead of solving a complex stochastic optimization problem defined on a fixed set of forecasted scenarios, we propose to use an iterative process: We repeatedly generate new scenarios, solve them using advanced optimization methods, and find the corresponding investment solutions. Our novel way of optimization will use deep generative models (DGMs) to generate small sets of scenarios matching the real distribution, and use a guided local search process to select scenarios that properly reflect properties of the full set of scenarios. The outcome of the iterative process is a palette of near-optimal solutions, which can be analyzed using data science methods to extract associations in investments, outrank dominated choices, and organize investments according to urgency. Knowing the full spectrum of possible choices opens up for a much broader discussion of investment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Spoken language dialogue systems and components - best practice development and evaluation' under Fourth Framework.

assistant: **Concept**

The DISC Action aims to take dialogue engineering and its successful commercialisation a significant step forward by pursuing the following specific objectives:- To carry out a detailed review and investigation of existing practices for a wide range of SLDSs and components development and evaluation.- To define a detailed current best practice scheme of methods and procedures for SLDSs and components development and evaluation. - To develop to the stage of industrial applicability a range of concepts, methods and software tools based on ideas and preparatory work at the partner sites.- To test methods, procedures, concepts and software tools on industrial and applied academic development projects to the extent feasible within the duration of the Action.The industrial relevance of the expected results are:- Progress towards the integration of SLDSs best practice into software engineering.- Improved feasibility assurance of development projects (risk minimisation) and more exact feasibility assessment.- Improved procedures, methods, concepts and software tools.- Reduced development costs, accelerated development, improved maintenance and reusability.- Improved product quality and increased flexibility and adaptability.- Progress towards the establishment of dialogue engineering standards.- Improved guarantees to end-users that a product has been developed following best software and cognitive engineering practice. Enabling end-users to objectively assess different systems and components technologies against one another and choose the right product according to quality, price and purpose.To achieve its objectives, DISC will (i) investigate a broad selection of state-of-the-art SLDSs to identify current practice and pinpoint its deficiencies; (ii) develop, test and dissemin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Designing waves for the people' (DWAVE), addressing dissemination and exploitation.

assistant: **Impact**

The objective of this project is the creation of Wavegardens all around the world. A Wavegarden is a place where surfers can practice surf: a lagoon in which a mechatronic device creates waves that could fulfil surfers expectations. According to the report “Blue Growth Scenarios and drivers for Sustainable Growth from the Oceans, Seas and Coasts, Third Interim Report, March 2012“ an important niche in coastline tourism is represented by nautical sports. For example, 10 million people in the world travel each year to wind and wave surfing destinations and the trend is growing, and 500 thousand more people every year practice this sport. Surfing is ranked in the top 20 most popular and fastest growing sports in all countries, cultures and demographics. The surfing industry, with an economic impact in the range of US$100 billion, is estimated to continue its growth in the years to come. The ‘stoke’, or feeling, of surfing, which has been limited to the lucky few who live near quality surfing waves, is now accessible to everyone thanks to Wavegarden.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Eurofoetus Conference on Fetoscopy and Invasive Fetal Diagnosis & Therapy' under Fifth Framework.

assistant: **Concept**

This project aims to organise a euroconference on <<Diagnostic and operative fetoscopy, its place in modern invasive fetal diagnosis and therapy>>. (Young) researchers will be offered the opportunity to participate actively in a one-day conference, dealing with 7 different themes of the highly specialised field of invasive fetal medicine. Each theme will be introduced by a young researcher with proven expertise in the field, giving an overview of the state-of -the-art and defining burning issues in current research. Selected papers will then be presented by participants followed by a discussion with the audience and experts. Each thematic session will be closed by a senior authority summarizing the merits and shortcomings of the selected presentations. 100 participants will be allowed participation to this conference, based on blinded review of abstracts. The 40 best ranked papers will be allowed oral presentation, the remaining 60 papers will be invited for poster exhibits. Three prizes will be awarded.All participants to this Euroconference will be offered free participation to an international symposium on invasive fetal diagnosis and therapy, immediately following the Euroconference. No support for this symposium is being seeked with this application.The symposium is organised as part of the dissemination plan of the shared cost Biomed 2 contract EUROFOETUS, a project focussed on fetoscopy in fetal medicine. It is co-sponsored by the US-National Institutes of Health, confirming its level of excellence. A series of key-note lectures by the world's most famous experts offers a complete overview on invasive fetal medicine. This back-to-back organisation allows to use the financial means and logistics of this prestigious high level symposium to support the Euroconferenc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'ERA-Net for research programmes on rare diseases'.

assistant: **Objectives**

There are at least 6000 to 7000 distinct rare diseases, the great majority of them being of genetic origin. Although individually rare, taken together, rare diseases affect at least 20 millions persons in Europe and represent a major issue in health care since a large percentage of these diseases lead to a significant decrease of life expectancy, and most of them cause chronic illness with a large impact on quality of life and the health care system. The status of knowledge on the different rare diseases is heterogeneous, while evidence based therapy is available only for a very small minority of them. Therefore further research on rare diseases is badly needed but is hampered by lack of resources at several levels. (1) Few scientists work on one specific disease. (2) There are few patients scattered over a large geographic area, causing difficulties to gather cohorts required for studies. (3) Usually existing databases and material collections are local and small, they are not accessible or standardised. (4) Diseases often have complex clinical phenotypes and require interdisciplinary approaches to treatment and interdisciplinary cooperation for research. In order to ameliorate these problems the EU-member states France, Germany and Spain have recently created national programmes explicitly dedicated to support research on rare diseases and to enhance networking among scientists in the field of rare diseases. The first and main objective of this Specific Support Action is to explore possibilities for creating synergies by transnational coordination and cooperation between these three partners. Since research on rare diseases is usually integrated into programmes defined either by indication or by methodological approaches the second objective of the SSA is to identify
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ethical diversity and regulatory harmonisation: an empirical exploration of research ethics committees following the directive on good clinical practice' under Sixth Framework.

assistant: **Concept**

The aims of this project are: to explore the way in which Independent Ethics Committees (lECs) assess clinical trials protocols for ethical suitability; to assess which variations are necessarily a consequence of local cultural differences, and which are not; to highlight the way in which European pharmaceutical harmonisation can incorporate ethical diversity and develop best practice for lECs.As a result of the Directive on Good Clinical Practice (GCP), since the 1st of May 2003 Independent Ethics Committees have had a statutory role under European Legislation in the ethical assessment of clinical drugs-trials. This is part of a general move towards the harmonisation of pharmaceutical regulations, both worldwide and within Europe (e.g. the setting up of the EMEA).But there is a largely unexplored tension between this drive towards harmonisation, now seen in ethical review, and the important role cultural and ethical diversity plays within Europe. For example, even within a single member state (the UK), there has bee n considerable tension between the requirement that clinical trials be assessed by ethics committees and the range and diversity of opinion such committees have, even regarding the same clinical trial.This problem will be magnified at the European level. This project will use qualitative methods to compare the decision-making processes of ethics committees in four different countries (UK, Sweden, Portugal and Hungary). The team will recruit a researcher from each of these countries, showing a high degree of mobility.In its analysis the team will use dimensions of comparison such as: differing interpretations of what is meant by informed consent; the relationship between need for technical ability to understand material and the democratic principle of lay me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Workshop Environmental impact of oil transportation""' (ENIMOT).

assistant: **Concept**

The main goals of the Workshop are: -creation of cooperation between scientist from European Union and NIS for solving of regional environmental problems;- exchange of information and experience on protection of the environment along the oil transportati on routes, -initiation of public movement and collaboration for joint solving of regional environmental problems of oil transportation. Main topics: -Environmental impact of oil transportation by tankers, pipe-lines, railway , -Oil s torage in the reservoirs parks, -Pollution sources in the terminals and pump stations, -Protection of fauna and flora along the oil transportation routes, -Environmental impact of construction of pipe-lines, -creation o f public movement and collaboration for solving of regional environmental problems of oil transport. Main discussions will be foxed to Caspian oil transportation. Participants- about 30, from Austria (1), Norway (1), Greece (1), Turkey (2), Israel-(1), G eorgia-(3), Kazakstan-(3), Ukraine(1), Russia (2), Azerbaijan- (15). Participant Organization: -Scientific Centers, Universities, Oil Companies, NGOs, Government and municipality.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Numerical modelling and characterization of quantum-dot vertical-cavity surface-emitting lasers and semiconductor optical amplifiers using realistic quantum-dot wave functions and carrier distributions' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Semiconductor quantum dot (QD) lasers and optical amplifiers have drawn much attention due to expected performance improvement over quantum well (QW) lasers and amplifiers.GaAs-based 1.3-1.55 um vertical-cavity surface-emitting lasers (VCSELs) and semiconductor optical amplifiers (SOAs) are very promising to be used as low-cost and high-performance optical devices for fibre-optic metropolitan and local area networks, which current InP-based QW optoelectronic technology cannot provide.Many characteristics of current 1.3-1.55 um QD VCSELs and SOAs fulfil system requirements, but there are still many physical and technical issues to be further investigated before the deployment of mass production.In this project, the applicant will develop the advanced numerical modelling tools for QD VCSELs and SOAs based on the realistic QD wave functions and carrier distribution with its experimental verification. The realistic wave functions of QDs will be calculated in various three-dimensional QD potential and strain distributions. The carrier scattering time constants in QDs will be quantum-mechanically calculated.The material optical gain and carrier distribution will be obtained by solving the coupled rate equations. The static and dynamic output performance of QD V CSELs and SOAs will be calculated by incorporating the calculated QD parameters into simulation software tools. Finally, the calculated results will be compared with the measured data for verification.This project will contribute to understanding how the unique QD characteristics affect output performance of QD VCSELs and SOAs, and providing with a practical guideline to design high speed, high power QD VCSELs and polarization-insensitive QD SOAs.Realization of the low-cost and high-efficiency 1.3-1.55 um QD VCSELs and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Rapid Nanofluidics Valves for Single-Molecule Imaging' under Horizon Europe.

assistant: **Concept**

A major challenge in biomolecular research is the investigation of biomolecular interaction at single-molecule level. Biomolecules possess heterogeneities of high physiological relevance that can only be unravelled with single-molecule tools. All current single-molecule imaging methods, however, require chemical modifications, such as fluorescent labelling or immobilization onto a surface, which might alter the biomolecule’s natural behaviour.Recently, I have developed a ground-breaking optical microscopy method – Nanofluidic Scattering Microscopy (NSM) – whose unprecedented resolution enabled me to bypass those limitations and to image individual small proteins in free motion without any label. Despite these attractive attributes, in its current form, NSM does not allow for quantitative study of interaction kinetics between individual molecules. Due to the inherently fast Brownian motion, the time that a molecule spends on average in the optically probed volume – a nanofluidic channel – is substantially shorter than the time required to record a statistically relevant number of association and dissociation events.In this project, we will develop an essential nanoscopic component – a rapid nanofluidic valve – that will enable to confine and release interacting biomolecules to and from the nanofluidic volume. The nanofluidic valves will be based on the principles of thermo-responsive polymer hydrogel in combination with nanoplasmonic heating. The integration of the nanofluidic valves with NSM will enable to track evolution of individual biomolecules at single molecule level, without the need of chemical modifications and in conditions that mimic an in-vivo state.The project will deliver a unique bioanalytical tool that will make key contributions to the fundamental under