RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Characterization of proteins that are involved in actin nucleation on phagosomal membranes' under Fourth Framework.

assistant: **Concept**

Research objectives and content Little is known about actin nucleation in non-muscle cells, a process usually associated with membranes. It is often induced by signals from outside the cell and some phosphoinositides, especially PIP, PIP2 and PIP3 seem to be important. Moreover, many actin binding proteins can bind these lipids. Recently a simple in vitro assay was developed by the Griffiths group to study actin nucleation on purified phagosomal membranes. Actin nucleation in this system is dependent on PIP2 and on peripheral membrane proteins that are removed by 'high salt' treatment. This process can be reconstituted by adding 'high salt' extracts to salt-stripped phagosomes. Further, a correlation was found between the age period in which phagosomes can fuse (in a separate assay) and that in which they best nucleate actin. I propose to identify and characterize the protein(s) which nucleate(s) actin on phagosomal membranes and to try to correlate its (their) function with the fusion process. Training content (objective, benefit and expected impact) At the EMBL I can learn and apply the use of an elegant system that is highly versatile to study membrane-actin interactions as well as membrane fusion in a (for me) new field. Links with industry / industrial relevance (22) A deeper understanding of these processes is a fundamental cell biological problem that is important for all pharmaceutical companies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'BLOCKCHAIN BASED PLATFORM FOR BRINGING SLOW FOOD IDEAS AND FAMILY OWNED FARMING TO CYBERSPACE' (2014-2020).

assistant: **Innovation**

During the last decades farming and production of gourmet foods, traditionally dominated by Mediterranean region, experienced a setback because of decrease of inhouse consumption. This forced the whole market towards export to strong economies with high quality of life. Export markets bring challenges to small farms and producers of gourmet foods. They have no experience and funds to cope with refocus from local sales to export. This puts them into disadvantage reaching international markets. The wish to get the share in export forces farms to accept wholesalers as a necessity, to sell at 30-50% of prices, to agree that distributors get the largest share of value created by farmers.I Go Slow offers a unique solution for the problems of the industry. The main objective is to develop a platform based on integration of Internet, e-commerce, Cloud and Blockchain technologies for promoting key ideas of Slow Food movement and family owned farming into cyberspace. For farmers the platform provides a user-friendly, reliable channel for presenting themselves directly to consumers without intermediaries. It requires little if any marketing funds, and allows engaging with customers directly for visits, product sales and sharing next harvest. All interactions are supported by underlying Blockchain technology and carried out with the use of a native Slow Token ecosystem. Any interaction between farmers and consumers strengthens Authenticity Rates, leaves no space for manipulations of intermediaries and builds trust. Trust gives credibility to farmers. It contributes to the secure content of global cyberspace.I Go Slow platform offers producers a compelling proposition to increase their global exposure, maximize profit by getting most of the created value themselves. It is a socially
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Assessing Seismic Performance of Integral bridges for improved Resilience and lifecycle in Earthquake-prone areas' in the context of a Horizon 2020 call.

assistant: **Objectives**

The ASPIRE project aims at assessing the feasibility to construct Integral Abutment Bridges in earthquake-prone areas. In the last years in Europe there was an increasing interest on this particular class of structures, characterized by the absence of bearing supports and expansion joints, elements commonly used in bridges which are subjected to deterioration due to ageing and thermal effects, thus requiring expensive periodic maintenance. Integral Abutment Bridges have very low costs of maintenance and improved durability while their increased redundancy can result to superior behavior during an earthquake. Still, there are high uncertainties and a lack of standard procedures to systematically evaluate their seismic performance. As a consequence, no indication is given in Structural Eurocodes as well as in other major seismic codes worldwide. The project proposes an innovative multi-disciplinary procedure including: (a) the evaluation of structure-specific seismic hazard; (b) experimental investigation on the shaking table of the University of Bristol Earthquake Lab (c) the calibration of numerical models including their complex Soil-Structure Interaction; (d) the development of novel fragility curves tailored to the salient features of integral bridges, and (e) the development of Risk and Resilience metrics for the estimation of the improved lifecycle associated with the better durability and lower damage of integral bridges due to earthquakes. The project will be implemented at the University of Bristol, integrating and extending the experimental and numerical capabilities of the Earthquake Laboratory on Integral Abutment Bridges, improving at the same time the skills and competences of the researcher. The results of the project will provide a robust scientific basis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Reference Materials for Biofuel Specifications' (BIOREMA) targeting Seventh Framework.

assistant: **Abstract**

With the increased addition of biological products to petrol and diesel, e.g. ethanol and FAME, the quality of these products becomes more important. There is, however, up to now no international consensus on the technical specifications of biofuel. Nor is it clear what measurement standards, reference materials and measurement techniques are needed.  The proposed project will deal with the subject of measurement standards (= reference materials). Reference materials with well-characterized reference values are essential for pre-normative research and standardization, i.e., in the development and validation of measurement methods. In the project it will be investigated which reference materials are already available and how the reference values for these materials were established. From this investigation it will become clear for which parameters and for which type of bio-ethanol and FAME reference materials are missing. The next step will be to investigate the feasibility of developing these reference materials for the identified parameters. Finally the project will establish the current quality of measurement practice by means of interlaboratory comparisons using these materials. The information supplied on the applied methodology and the performance characteristics can be used for the development of harmonized standard methods. An additional aim is to provide guidance and material for producing reference materials for the different test methods required by the ultimate global biofuel blend specifications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Platform for European Medical Support during major emergencies' in the context of a Seventh Framework call.

assistant: **Objectives**

In Europe, one of the core emergency response services to deadly threats such as pandemic disease and major terrorism attacks is the European Health Services (EHS). The EHS comprise key stakeholders that include hospitals, community health services, pre-hospital emergency care services, medical suppliers, rescue services, health related voluntary services and others.  It is crucial to the EHS that it remains in an excellent state of preparedness supported by first-class planning and decision support tools. Moreover, in the response phase, EHS need consistent, coordinated and standardised advanced support methods and tools providing support in critical tasks like e.g. early threat detection, common operational picture, creation of surge capacity etc. Finally, at a pan European level, EHS also need an interoperable framework with the ability to provide a coordinated European response to any major medical incident.PULSE aims to meet these challenges.The project will begin by a) comprehensively studying the procedures, processes and training requirements in current operation at the EHS using the support of end users available to the project. It will then b):• Develop standard and consistent response procedures and processes;• Provide tools to support decision making in both preparedness and response phases;• Provide a Framework that ensures decision makers have access to timely key data, planning and decision support tools and to international best practice and lessons learnt;• Present innovative training techniques to improve personnel response training;• Develop an ‘emergency app’ for smart phones that will allow users fast and flexible access to emergency resource availability information;The primary benefit will:• Reduce administration, bureaucracy and ensure better use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Overnight Volatility in Financial Markets:  Causes and Consequences' under Seventh Framework.

assistant: **Concept**

This project consists of four parts, each of which will analyze a different aspect of interbank overnight rate volatility (hereafter “OV”).In the first part of the project, the implications of OV on longer term interest rates will be investigated. The expectations hypothesis notes that longer-term rates should equal expected future short-term rates plus a term premium.  We will look for evidence that OV can affect the term premium embedded in longer-term rates. The analysis will be conducted for the US, Euro Area, and the UK. Cross-country comparisons are essential to identify the impact of OV under different monetary policy frameworks.  We expect to find that lower OV in the interbank market leads to a lower term premium by reducing uncertainty, and thus lower longer-term rates for a given setting of the overnight rate.In the second part of the project, we will focus on the sensitivity of OV to different reserve management regimes by utilizing a dynamic optimization model of daily reserve management.  Using this model, we will investigate the implications of alternative reserve management strategies on OV including the reserve management practices at the Fed and the ECB.  This way, we will check whether a particular reserve management strategy is preferable in terms of achieving lower OV.The third part of the project will utilize an interdisciplinary causal search algorithm to investigate the links between OV and broader macroeconomic variables such as the GDP, the price level, and the yield curve in a structural vector auturegression framework.The last part of the project will develop an intertemporal optimization model to estimate the demand for term deposit facilities and their implications on OV. Term deposit facilities are established by the central banks (Fed, EC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'On-surface design of lanthanide coordinated networks featuring single atom magnetism' (4f-Mag) targeting Horizon 2020.

assistant: **Abstract**

The capacity of investigate and tailor the materials properties down to nanoscale created new perspectives for the development of functional devices using single atoms or molecules. Concerning magnetism, the stabilization of magnetic remanence in single atoms represents the ultimate limit on the size reduction of storage devices. After recent advances in this field, lanthanides have emerged as promising candidates for atomic magnets. However, the high diffusion of single standing atoms hinder the development of real-world applications. The next step to further advance towards practical devices is the coordination of these atoms in networks preserving their outstanding magnetic properties. This project will explore the high versatility of molecular linkers to coordinate lanthanides atoms. The combination of state-of-art surface science techniques as scanning tunneling microscopy (STM), non-contact atomic force microscopy, X-ray absorption spectroscopy (XAS) and X-ray magnetic circular dichroism (XMCD) allows a complete investigation of their fundamental properties. It will be possible to unveil the structural, electronic, chemical and magnetic properties of lanthanides networks prepared on different surfaces. The 4f-Mag project aims to find out suitable combinations of surface and molecular linkers to design regular networks of lanthanides maintaining their functionality as single atom magnets and enhancing their remarkable magnetic properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Network for Sensor Knowledge Transfer' (IBS-NETWORK).

assistant: **Innovation**

The aim of Research Exchange programme Ionophore Based Sensor Network (IBS-NETWORK) is to establish the scientific basis from which the utility and potential for IBSs can be extended in a range of new sectors. To achieve this requires the combined expertise from a number of disciplines and backgrounds, including analytical science focused on IBSs, organic synthesis, material science, microfluidics and statistics. All these disciplines exist within the partnership IBS-NETWORK. We bring together in this project a multidisciplinary team of 10 research groups from 8 institutions. These teams originate from 7 countries within and outside of Europe, all recognised leaders in their respective fields. Our partners possess complementary skills and knowledge and the necessary skills to develop new methodologies and sensing platforms. IBS-NETWORK includes researchers involved in basic research working with researchers with applied expertise. The collaborations of the partners involved in this project represent a significant audience of stakeholders from academia and industry, national and international levels, creating high potential for the take-up and use of results.We expect that the research exchange between these groups will achieve the following main goals:• Greatly expand the utility and potential for application of IBSs in a range of new sectors with recognized potential for benefit (climate action, health, wellbeing, marine and maritime research and food security)• To strengthen existing and create new research collaborations between experts from a number of disciplines, techniques and equipment.• To provide the basis for long-term, sustainable collaborations in research with the knowledge to take forward developments in the IBS fieldThese goals will be achieved through a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Next-Gen NMR Prediction and Analysis: A Cutting-Edge Tool for High-Precision Structure Identification' under Horizon Europe.

assistant: **Concept**

The proposal aims to advance diagnostic technology by enhancing Nuclear Magnetic Resonance (NMR) as a tool for personalized medicine. Current NMR techniques face limitations in sensitivity, resolution, and uncertainty quantification, particularly in analyzing complex biological mixtures. These challenges hinder its potential to deliver the precise, non-invasive diagnostics required in personalized healthcare. Our solution is an advanced NMR software that integrates quantum-chemical calculations with empirical data to significantly improve NMR's accuracy and reliability.Current methods fall short in accuracy when dealing with complex or novel molecular structures. Our tool addresses these limitations by providing accurate conformer sampling and error propagation techniques to quantify uncertainties in peak assignments and chemical shift variations, which are crucial for high-precision analysis. Additionally, it aims to enable low-field NMR devices as a viable option for advanced diagnostics, particularly in cost-sensitive sectors such as pharmaceuticals, biotechnology, and environmental science. The software automates many aspects of NMR analysis, reducing time and effort for researchers while improving accuracy, enabling wider adoption and faster results.This innovation is particularly relevant to the EIC Transition program’s focus on bringing deep-tech innovations from lab to market. The software has the potential to revolutionize fields like drug discovery, personalized medicine, and environmental monitoring, opening new markets for point-of-care diagnostics and expanding the use of low-field NMR in industries previously restricted by high costs. Early interest from key players, including Merck and the University Medical Center Freiburg, supports the commercialization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'IMPROVED FASTENING SYSTEMS OF CLADDING WALL PANELSOF PRECAST BUILDINGS IN SEISMIC ZONES' (SAFECLADDING), addressing dissemination and exploitation.

assistant: **Impact**

The current design practice of precast buildings is based on a frame model where the peripheral cladding panels enter only as masses without anystiffness. The panels are then connected to the structure with fastenings dimensioned with a local calculation on the base of their mass for anchorage forces orthogonal to the plane of the panels. This design approach does not work, as it was recently dramatically shown by several recent violent shakes, like L’Aquila in 2009 and Grenada in 2010. The panels, fixed in this way to the structure, come to be integral part of the resisting system conditioning its seismic response. The high stiffness of this resisting system leads to forces much higher than those calculated from the frame model. These forces are related to the global mass of the floors and are primarily directed in the plane of the walls. Furthermore, the seismic force reduction in the type of precast structures of concern relies on energy dissipation in plastic hinges formed in the columns. Very large drifts of the columns are needed to activate this energy dissipation foreseen in design. However, typically the capacity of the connections between cladding and structure is exhausted well before such large drifts can develop. Therefore, the design of these connections cannot rely on the seismic reduction factor used for design of the bare structure. New technological solutions for connectors with proper design approaches areurgently required. The research project SAFECLADDING is thus aimed to investigate, by means of a balanced combination of experimental andanalytical activity, the seismic behaviour of precast structures with cladding wall panels and to develop innovative connection devices and novel design approaches for a correct conception and dimensioning of the fa