RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Shaping text, Shaping melody, Shaping experience in and through the Old Hispanic office' (2007-2013).

assistant: **Innovation**

Scholars have neglected Iberia’s early-medieval Christian liturgy, reflecting the insurmountable difficulties the non-pitch-readable music notation presents for conventional methodologies. This project’s trans-disciplinary methodology integrates the study of melody and text across the Old Hispanic liturgy for the first time. With theologians and musicologists, I will explore the potential the Old Hispanic chants had for promoting a particular religious experience within an almost-forgotten liturgy. Together, we will bring the many-layered and cross-referential Old Hispanic approach to text choice, musical punctuation and melodic pacing explicitly to the attention of modern composers, encouraging them to explore compositional processes that evoke similar spiritual responses. The composers will act as a communicative channel between the pure scholarship demanded by the Old Hispanic material, and contemporary concert audiences and congregations. We will produce a team-authored book, several peer-reviewed articles, a series of publicly performed compositions, an EU-workshop and an International Festival of new music inspired by the project findings. The Old Hispanic liturgy is one of the musical, intellectual and theological jewels of our European cultural heritage, and this project will give a wide audience a holistic understanding of its richness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'UPF Fellows' (UPFellows) under Seventh Framework.

assistant: **Objectives**

The UPFellows program promoted by Universitat Pompeu Fabra - UPF aims to offer career development opportunities to outstanding junior postdoctoral researchers of any nationality. They will join one of the most unique and dynamic research environments in Europe, where they will be able to advance in their research and further develop their professional skills with a career development plan guided by a senior scientific mentor and strong administrative support.From an institutional perspective, the program’s objectives are:- To maximize the potential for UPF to attract top quality researchers from all over the world, particularly by offering competitive salaries, attractive employment and working conditions, and career prospects.- To boost an exemplary postdoctoral program aligned with the principles of the Charter & Code which contributes to reinforce current good practices- To serve as an initial impulse and pilot for a permanent internal postdoctoral program which UPF plans to maintain beyond the COFUND period.The applicant-oriented objectives are:- To enhance career prospects by providing structured postdoctoral training; scientific, technical and personal support; and monitoring and evaluation that will maximize fellows’ opportunities for continued professional development and the possibilities of continued success.- To benefit from the intensive research environment at UPF (11 ERC grants)- To guarantee the maximum degree of information about and equality of opportunity to access postdoctoral employment opportunities at UPF.- To provide a stepping stone to future employment opportunities, whether within Spain or abroad.The program is an “incoming” scheme that will, in this pilot, consist of 2 calls, one during each of the first 2 years. Each call will offer 12 3-year
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'An Integrated Network of  Glucose Sensing Cells in Glucose Homeostasis' (INSIGHT) under Seventh Framework.

assistant: **Objectives**

Glucose sensing cells constantly monitor glucose absorption from food and variations in blood glycemic levels. They control the secretion of GLP-1, insulin and glucagon, and the activity of the autonomic nervous system. These hormonal and nervous signals coordinate glucose utilization by liver, fat and muscle, and endogenous glucose production as well as feeding and energy expenditure. Type 2 diabetes, a disease that afflicts an increasing proportion of the world population, is characterized by insufficient insulin production by pancreatic beta-cells, abnormal secretion of GLP-1 and glucagon, and is often associated with imbalance between feeding and energy expenditure. Type 2 diabetes can thus be considered a disease of glucose sensing. Here, I propose a research program using cell biological, genetic, genomic and physiology techniques to investigate three aspects of this integrated glucose sensing network:1. The identification of novel molecular pathways activated by GLP-1 and that control adult beta-cell proliferation, glucose competence and apoptosis in order to maintain sufficient insulin secretion capacity.2. The identification and molecular characterization of brain glucose sensors, which share functional similarities with pancreatic beta-cells, and which control glucose homeostasis and pancreatic islet mass and function.3. The discovery by unbiased genetic-genomic analysis of loci, genes, and gene networks involved in central hypoglycemia detection and the secretion of glucagon, a process whose deregulation is a major limitation in insulin treatment of both type 1 and type 2 diabetes.Together these investigations will bring new knowledge on the integrated control of glucose homeostasis that may lead to novel strategies to control diabetes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The role of ethylene and of ERF gene regulators in the grapevine berry ripening' in the context of a Seventh Framework call.

assistant: **Objectives**

Grapevine is one of the most important crops in Europe for production and cultivated area. Ripening is a process that increases flavor and aroma due to the accumulation of anthocyanin and aromatic compounds in berries but it limits transport, store and manipulation. Grape ripening follows a double sigmoid curve characterized for a first volume increase of the berry and a second phase, also called véraison, of accumulation in sugars, softening, coloring and a second increase in size. Grapevine is traditionally classified as a no climacteric fruit supposing an ethylene independent pathway while new recently insights showed a common genetic mechanism between climacteric and no-climacteric fruits where ethylene plays a fundamental role (Lin et al., 2009).The final step in ethylene signaling is regulated by transcription factors called Ethylene Responsive Factors (ERFs) that are involved in fruit ripening and stress processes. It was demonstrated that they bind to a specific GCC-box and modulate genes expression (Fujimoto et al., 2000) and they have been described in tomato, Arabidopsis and other fruits. At FEM, the two interesting ERFs, VvERF045 and VvERF063, have been identified showing the most interesting expression profile correlated to véraison in grape. The first accumulated its transcripts after veráison while the second one showed a clear decrease in expression. Also transgenic plants overexpressing VvERF045 were obtained.The main purpose of the project is a first characterization from a molecular, morphological and biochemical point of view of these transgenic plants to observe the main phenotypical alterations. The research is further focused on the identification of the targets of VvERF045 to better know. We will focus on the most interesting genes resulting for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular mechanisms of bacterial invasion and colonization in the human gut microbiota' in the context of a Horizon Europe call.

assistant: **Objectives**

The human gut microbiota plays a critical role in safeguarding human health by defending against pathogens and supporting essential metabolic and immune functions. Nevertheless, our understanding of how the gut microbiota influences bacterial invasion and evolution within the human body is incomplete due to the complexity of these interactions. Furthermore, the specific mechanisms through which commensal bacteria, such as Escherichia coli, successfully invade and evolve in distinct human gut microbiota compositions remain unclear. The MICROINVADER project aims to address this knowledge gap, utilizing an established in vitro gut simulator to investigate the precise mechanisms underlying the successful invasion of distinct human gut microbiota ecosystems by the commensal bacterium E. coli. Furthermore, MICROINVADER aims to characterize at the molecular level the processes that shape the evolution of invading strains in response to specific human gut microbiota compositions. Subsequently, MICROINVADER will validate these findings through in vitro and in vivo experiments, focusing on quantifying the selection strength acting on the genetic mechanisms that are crucial for bacterial invasion and colonization in different human gut environments.By unveiling these novel mechanisms driving bacterial invasion and colonization within diverse human gut microbiotas, MICROINVADER seeks to provide critical insights that may have far-reaching implications for enhancing human health. Ultimately, MICROINVADER aims to contribute to our understanding of how to manipulate the gut microbiota in ways that promote and sustain overall well-being.


**Keywords:** Colonization resistance ,  Intrahost evolution ,  E. coli ,  Human microbiome ,  Experimental evolution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Reappraising Middle Nubian Identity through Material Culture' (INBETWEEN) targeting Horizon 2020.

assistant: **Abstract**

INBETWEEN is a theory-driven, comparative archaeological reassessment of the Middle Nubian cultures (C-Group, Pan-Grave, and Kerma) during the Second Intermediate Period in Egypt and Nubia (c. 1750-1500 BC). The project operates in the liminal spaces between the groups to re-evaluate their relationships with one another, asking how they are the same, how they are different, and if imposed modern cultural divisions are valid. Material culture takes the focus, and an analysis of the relevant chaînes opératoires using cultural phylogeny, entanglement, and border theory will identify shared or differing technological heritages that may reflect corresponding cultural relationships.  The project challenges modern constructs of the Middle Nubian cultures as bounded cultural entities: how did the ancient Nubians perceive their own cultural boundaries? how fluid were they? A deep theoretical investigation of the processes driving cultural change will address questions of how and why cultural components crossed boundaries in certain situations, and what impact this had upon each group’s identity.  INBETWEEN will be the broadest and most up-to-date survey of Middle Nubian material culture available. The acquisition of new skills via training in XRF-spectroscopy and RTI photography to analyse raw materials and technological processes will yield concrete evidence to support the outcomes. Research collaborations exploring the application of archaeological and anthropological theory will further expand my skillset in new directions, building my European network. The theoretical framework makes the project relevant to multiple disciplines, and the resulting monograph and publications will serve as a methodological case study for archaeologists and anthropologists alike. By examining th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Industrial quality assurance control' (IQAC).

assistant: **Innovation**

In the current competitive market, industrial companies must establish and maintain Total Quality Management Systems (TQM), in order to fulfil important objectives:- To assure the appropriateness of the products supplied by the organisation.- To obtain the confidence of the customers (existing and prospects)- To accomplish Governmental or Administrative rules in their respective markets.Many European industrial companies have just passed, are passing, or will pass in the near future through an ISO-900x Certification procedure as a first step to implement TQM in their organisations. Frequently, this process is done in a manual basis, by hiring external consultancy services to define and to implement the Quality System. Later, the company must maintain the Quality Management System (QMS), control the quality related documentation, continuously assess the state of the system, allow its users to introduce suggestions or modifications to improve the system functionality and, to control this process, pass successive internal and external audit reviews. These requirements impose significant costs to the companies since normally the QMS is fully based in documents and procedures stored and maintained in a paper format.In addition to the previous requirements most target organisations are currently exploring Business Process Re-engineering (BPR) technologies and methods, as a way of improving their competitiveness. Unfortunately many BPR projects fail because of the high costs and difficulties of obtaining accurate information about the processes, and in the deployment of the process changes because of organisational resistance. This project focuses on integrating TQM and BPR objectives, minimising the costs of information capture and implantation through an appropriate synergy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unravelling the mechanism of eukaryotic helicase activation' (MechHelicaseActiv8on).

assistant: **Innovation**

The initiation of DNA replication requires dynamic biomolecular interactions, which are temporally and spatially regulated to allow genome duplication only once per cell cycle. During eukaryotic replication initiation, the MCM helicase is loaded as an inactive double hexamer encircling double-stranded DNA (dsDNA). It is activated by a set of proteins called firing factors in a kinase-dependent manner, thereby forming the CMG complex (Cdc45, MCM, GINS), which encircles single-stranded DNA (ssDNA) and thus can unwind dsDNA.  Although the essential components for helicase activation are known, we do not understand the remarkable topological transition between the inactive helicase encircling dsDNA and the active helicase encircling ssDNA. For this to happen, the ring-shaped MCM helicase must open between two subunits in a regulated manner. Therefore, I aim to (1) uncover the trajectory of ssDNA ejection from the helicase central channel and (2) dissect the role of firing factors in helicase activation. The objectives of the proposal are to determine (i) which helicase subunit interface has to open to eject ssDNA, (ii) which region of helicase interacts with ssDNA during helicase activation, (iii) what is the topology of helicase activation intermediates and (iv) which firing factors interact with ssDNA during strand ejection.  I will employ biochemistry with various crosslinking strategies combined with mass spectrometry to characterize the dynamics of protein-protein and protein-DNA interactions during helicase activation. Using cryogenic-Electron Microscopy (cryo-EM), I will investigate the structure of intermediates of helicase activation.  MCM helicase subunits and firing factors are conserved from yeast to humans, and their increased expression is correlated with poor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Advanced Modeling of Pulsar Emissions at Radiowaves'.

assistant: **Objectives**

Magnetospheres of neutron stars (NSs) represent unique plasma-physics labs of extreme environments characterized by ultra-high magnetic field strengths, relativistic processes, and the presence of quantum electrodynamic effects – parameters far unreachable on the Earth. Detailed information on these processes comes to us via coherent radio emissions of pulsars and possibly fast radio bursts (FRBs), being observed by fast-developing sophisticated instruments of radio astronomy like FAST, CHIME, ALMA, and in near future, SKA. However, no agreement has been reached on their exact coherent radio emission mechanism that can interpret the observations, mainly because the modeling of the radio emissions requires operation of the extreme-physical processes and simultaneous consideration of the wave coherency at plasma kinetic micro-scales.This project addresses the question of which specific mechanisms are responsible for coherent radio emissions of NSs; in detail, which qualitative radio emission properties of pulsar pair-creation events and propagating kinetic Alfvén waves in the magnetospheres of NSs can lead to the interpretation of pulsars and transient events like fast radio bursts. The mechanisms will be investigated by combination of my expertise in first-principle particle-in-cell simulations of the micro-kinetic instabilities with the long-term experience in advanced dispersion and coherency analyses of radio waves in the simulations at the host institute.This combination of skills will allow me to make predictions on coherent properties of radio waves in terms of their total power, luminosity spectrum, its directivity and polarization as they escape the emission sources. I will distinguish, for the first time, how the extreme plasma instabilities lead to the coherent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Batch operations logistics and design' to be submitted under Fourth Framework.

assistant: **Abstract**

In the production industry, changes and uncertain market demands lead to important production and productivity losses, due to inappropriate scheduling of production process. This is particularly true in the case of batch process SME's which are often under-equipped to face such complex problems and are obliged to quickly adapt their production to the market in order to survive.The objective of this consortium is to demonstrate that the technology deployed in the trial application BOLD is able to solve these scheduling problems at low cost and as a consequence allows for an increase in productivity gains and a reduction in product losses.This demonstration will be reached through the industrialisation of a leading edge scheduling information solution prototype named MOPP, developed under RTD projects (EUROBATCH, JOULE programme, SECUNDO programme, PACE), and which has already shown in tests its ability to solve batch processing scheduling problems. The technology consists of the combined used of three basic programmed algorithms (probabilistic algorithm, heuristic algorithm and expert system algorithm) coming from mathematical models. The intelligent use of these algorithms in more than twenty compensation modules will permit to envisage and solve the majority of the possible problems which could occur in a production process in a short processing time.The expected advantages are the following:- high level of performance (short-time processing to give the optimised decisions, for scheduling and simulation of new solutions),- low cost and easy use with regards to US products used in the batch process market,- European origin, as the market is monopolised by such US solutions or generic solutions which provide scheduling, production management as well as accountancy functi