RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Aestheticization of Life and Cosmopolitan Modernity: The Poetics of Elegance in the Long 19th Century' (PoetEleg) under Horizon 2020.

assistant: **Objectives**

In the course of the long 19C the pursuit of 'elegance' emerged as a phenomenon aiming at an intensification of life through aestheticization. The distinguishing features of an 'elegant' appearance manifested themselves in the self-fashioning of an individual person (language, attire, behaviour) and in the shaping of domestic and public environments (artefacts, interior design, architecture). The concept of elegance was realized in social action and cultural practices, particularly in convivial conversation, entertainment and leisure activities. The  project demonstrates that one of the crucial patterns of modernity manifests itself in the phenomenon of elegance, which inaugurates a specific aesthetic of the surface as a distinguishing social feature as well as a marker transcending the established order: an imaginary community of urban origin that supersedes historically conditioned social and gender norms. Committed to the methods of transnational historiography, the study outlines the European topography of the so-called ‘elegant world’ in the tension between national aspirations and transnational aesthetic norms. The project focuses on ‘circulating things’ and examines the social agency of press and material goods. It pays particular attention to an innovative type of cultural journals, which reported in detail on urban social, cultural, and material life and helped spread the new urban styles of living and had a decisive impact on the staging of a new, imaginary cross-border community. Its geographic range is marked by the imperial metropolises, as well as by aspiring Central and Eastern European cities such as Berlin and Leipzig, Prague and Pest, which developed into new urban centres in the course of the 19C. The main output of the project is a monograph that map
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

An estimated 500.000 sudden cardiac deaths (SCD) occur each year in the European Union. Patients at risk for SCD may benefit from prophylactic treatment with an implantable cardioverter-defibrillator (ICD). ICD implantations have dramatically increased in recent years leading to multi-billion Euros of costs with significant regional disparities across Europe. Information on risks, benefits and costs supporting current guideline recommendations may be outdated, and the influence of gender remains unclear.EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in Europe) aims to generate contemporary clinical outcome data on ICD effectiveness in Europe. Clinical outcomes including all-cause mortality, appropriate and inappropriate ICD shocks, and quality of life (QoL) are assessed by:- a prospective study of patients undergoing indicated ICD treatment for primary SCD prevention, with a control group of patients not undergoing ICD treatment- a large European registry collecting available data on prophylactic ICD treatment- meta-analyses of available and emerging ICD outcome studiesQoL-adjusted cost-effectiveness will be estimated from actual cost comparisons and Markov decision models with attention to sub-groups, regional, and sex comparisons. Outcomes in patients receiving ICDs for primary SCD prevention will be compared in sub-strata, and with patients fulfilling guideline criteria but not undergoing therapy as per prior decision of treating physicians. Sub-groups with particularly large or small benefit from ICD implantation will be identified using risk markers and clinical characteristics with specific emphasis on gender. EU-CERT-ICD is expected to provide important novel information to validat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Smart Systems for Small Molecule Activation and Sustainable Homogeneous Catalysis' (EURECAT).

assistant: **Concept**

This proposal addresses currently unresolved fundamental questions concerning the activation and functionalization in homogeneous catalysis of challenging, inherently unreactive substrates like NH3, CO2 or water. Responsive ligands in combination with earth-abundant first row transition metals may hold the key to selective bifunctional activation of these small molecules. This innovative, bioinspired concept, utilizing ligand-metal cooperativity to enhance, tune and control the reactivity of base metals, mimics and circumvents the use of expensive and/or toxic 2nd and 3rd row transition metals. A comprehensive tool-box of readily accessible smart ligand systems with cooperative, redox noninnocent or adaptive features will be used for stoichiometric and ultimately catalytic reactivity studies with Fe, Co, Ni and Cu. This will result in mechanistic understanding of novel pathways for selective N-H and O-H activation on well-defined mono- and dinuclear cooperative complexes. Coupling and insertion reactions with alkenes to yield efficient C-N and C-O bond forming processes and CO2 functionalization will be investigated. This fundamental knowledge is then applied for unprecedented cooperative catalysis with first row transition metals. The project will ultimately result in important leads for the direct intermolecular hydroamination of alkenes, including with ammonia, which is one of the top-ten challenges in catalysis, and the efficient, sustainable production of carboxylic acids from CO2 and alkenes. Also relevant contributions to the oxidative activation of water for hydration reactions with alkynes are foreseen. When successful, my initiatives will enable significant breakthroughs in the design of unique, smart ligand systems for the cooperative activation and functiona
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of a multi-stakeholder dialogue platform and Think tank to promote innovation with Nature based solutions' (ThinkNature).

assistant: **Innovation**

Nature-based solutions (NBS) aim to help societies to address a variety of environmental, social and economic challenges in sustainable ways. They are actions which are inspired by and supported by nature. Some involve using and enhancing existing natural solutions to challenges, while others are exploring more novel solutions, for example, based on how non-human organisms and communities cope with environmental extremes. NBS are energy and resource-efficient, and resilient to change, but to be successful they must be adapted to local conditions.The main objective of the present project is the development of a multi-stakeholder communication platform that will support the understanding and the promotion of nature based solutions in local, regional, EU and International level. Through dialogue uptake facilitation and steering mechanisms as well as knowledge capacity building, the ThinkNature Platform will bring together multi-disciplinary scientific expertise, policy, business and society, as well as citizens. This platform will be efficient, fluent to use and attractive to a wide variety of actors and stakeholders because it merges all aspects of NBS in a clear, pyramidal methodological approach.  It will create a wide interactive society that builds new knowledge with a wide geographical scope. As a result, ThinkNature will provide the necessary policy and regulatory tools to solve significant societal challenges such as human well-being, tackling energy poverty, impacts of climate change, etc. through continuous dialogue and interaction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dis-inhibitory circuits in the human cerebral cortex' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Temporal co-ordination of the activity of cortical neurons underlies cognitive processes. Intracortical inhibitory circuits set temporal windows for modulation of glutamatergic pyramidal cell firing. In non-human mammals, the activity of the GABAergic neurons is governed by other specialised GABAergic neurons, which can dis-inhibit pyramidal cells. The overarching aim of this project is to define cellular and pharmacological mechanisms of dis-inhibitory circuits in the human cerebral cortex. These circuits could act as regulators of cognitive process. First, we will investigate the neuron types and their synaptic influences to characterise how dis-inhibition controls synaptic integration and the output of neurons. Second, we will elucidate synaptic plasticity in dis-inhibitory circuits, as plastic events likely represent physiological substrates of cognitive operations. Third, we will identify the subcellular sites and the mechanisms of action of key receptors for ACh, monoamines, endocannabinoids, neuropeptides and mGluRs modulating dis-inhibitory circuits, which are targets of small molecule CNS drugs, such as cognitive enhancers. We will test three hypotheses: 1) the human cortical pyramidal cell output is gated by compartment-specific dis-inhibition mediated by specific interneurons; 2) activity-dependent plasticity occurs in dis-inhibitory circuits and has consequences for the output of cortical pyramidal neurons; 3) small molecule drugs act via dis-inhibitory mechanisms at cell-type specific sites altering the inhibitory dynamics of pyramidal cells leading to subcellular redistribution of inhibition and alteration in their output. Combined electrophysiology/imaging with neuropharmacology and high resolution molecular receptor localisation will generate an unpreced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Instrument developement proposal: Development of a condensation particle detection system (COPAS) with multiple inlets for implementation on stratospheric aircraft or balloons' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Objective of this project in addition to the instrument design and construction is to have the COPAS instrument implemented on the Geophysika stratospheric research aircraft thus completing the Geophysika payload for aerosol measurements. During the Geophysika flights in connection with the Airborne Polar Experiment (APE) in the period from late 1996 until 1998 the instrument is utilised to obtain in situ stratospheric aerosol measurements with special emphasis on the lee wave mountain polar stratospheric clouds over the Scandinavian Alps and the Urals, and the mid latitude stratosphere. The detailed scientific objectives are to: - detect and count (not size) the smallest stratospheric particles in the important particle size range from 0.01 fm to 0.4 fm. - measure the number concentration of the smallest aerosol particles to characterise the microphysical processes of the formation and lifecycle of polar stratospheric clouds. - detect freshly nucleated aerosol particles from gas-to-particle conversion as basis of the Junge layer formation. - improve accuracy of total aerosol surface and volume measurements especially in volcanically quiescent periods. Most other airborne stratospheric particle instruments do not detect particles smaller than 0.01 fm and this small particle fraction is not included in total surface measurements. - obtain information about nonvolatile residues of the particles, i.e., address the homogeneous vs. heterogeneous nucleation issue for polar stratospheric cloud formation and for the formation of the stratospheric background aerosol. - separate PSC I from PSC II particles while enhancing PSC II particle concentration in the sample. Thus better particle detection counting statistics, an important issue for short events like lee wave PSCs. - measu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Linking Pathogen Evolution and Epidemiology' (PATHEVOL), addressing dissemination and exploitation.

assistant: **Impact**

The goal of the proposed research is a comprehensive understanding of how evolutionary potential of pathogen populations interacts with epidemiological dynamics in natural populations. The empirical work will be conducted on the specialist fungal pathogen Podosphaera plantaginis and its host plant Plantago lanceolata in a large network of host populations. I will address the key theories of pathogen evolution, involving life-history trade-offs, competition for resources under multiple infection, and sexual reproduction. This project takes advantage of the exceptional research opportunities offered by the focal study species to test models that have not been validated with respect to realized population dynamics and the persistence of pathogen populations.I have studied the coevolutionary dynamics between P. plantaginis and P. lanceolata for several years. Unique epidemiological data have been collected annually on the occurrence of the pathogen in a network of 4000 host populations since 2001. Recently, I have generated an EST library for the pathogen that allows and facilitates genetic studies. In the planned research, I will combine laboratory experiments with large-scale population surveys, genetic studies and mathematical modelling to achieve the objectives of this proposal.The proposed research has potential for groundbreaking results on pathogen evolution and epidemiology through: i) Simultaneous study of multiple forces driving pathogen evolution and their importance in natural populations, with direct connections to epidemiology. ii) Development of new methodology for the study of obligate parasites like P. plantaginis. iii) Construction of a stochastic, spatially explicit epidemiological model predicting pathogen occurrence from one season to the next with appl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Evolution from the first stars to massive black holes' (FS-MBH).

assistant: **Innovation**

The research program that is proposed addresses the formation and evolution of gravitationally collapsed objects in the universe, from the first stars formed from primordial gas to the most massive black holes that exist at present. Particular attention is paid on observational consequences of the theory, including the 21 cm emission and absorption from the early atomic medium when the first stars formed, the reionization period, the growth of black holes and the development of an alternative scenario to understand quasar activity, the capture of low-mass stellar black holes by high-mass black holes in galactic nuclei and the consequences for LISA events.The objectives will be achieved through development of theoretical ideas using analytical tools and simple numerical calculations, as well as the use of cosmological simulations. The work will be facilitated by hiring a European postdoc, and through the integration in the host institution where the cosmology group is involved in the Dark Energy Survey.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Early detection of HIV-1 using ultra-sensitive, rapid capacitive biosensor""', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The HIV pandemic continues to be a worldwide public-health problem.  The virus, which is spread through sexual contact, exposure to infected blood, or through shared syringes, is highly infective, rapidly mutates, and has no cure. Because there is no effective vaccine or other prophylaxis available, the current best practice and standard of care for those infected is an early, accurate diagnosis for the presence of HIV followed by immediate treatment on antiretroviral therapies and counseling. The most commonly used and widely accessible diagnostic tests and assays rely on the presence of HIV antibodies, but the window period before seroconversion takes place to produce these antibodies in the host can take up to six months. Moreover, newborns cannot be tested with these methods due to maternal antibodies masking their true HIV status. Thus, antibody-detecting approaches have major shortcomings in incidence and infant testing, which are critical components to early treatment and reduced transmission rates. Diagnostic tests targeting antibodies or nucleic acids are also susceptible to false or discordant results due to viral variations.Hence, of particular interest as a target then is the conserved viral capsid protein, p24 antigen. Under certain conditions, antigen assays can achieve sensitivities that nearly match those of NATs without the need for amplification steps, and the antigen has a much shorter window period than the antibody, allowing it to be much more effective at incidence and infant testing.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Variational Metadynamics'.

assistant: **Concept**

We propose to extend the time scale accessible to atomistic-based simulation methods from the current   range to millisecond and beyond without special-purpose machines.  We shall do this by combining and extending two recent developments: a recent reformulation of the enhanced sampling problem into a powerful variational principle that opens a wealth of possibilities and provides a novel and fruitful standpoint for new developments; and a procedure for extracting rates from enhanced runs.  We shall apply the methods thus developed to two major problems of great practical interest. One is the lifetime of a ligand-protein bound state.  This quantity is not easily accessible experimentally and yet it is crucial in drug design to determine the potency of a drug.  We plan to develop a viable and widely applicable way to compute it.  The other is a study of crystallization from solution, for which we wish to determine the nucleation mechanism and nucleation rates and understand and control crystal growth.  These are all issues of great relevance in engineering, pharmacology and nanotechnology.  Besides being relevant on their own merits, these two applications present different challenges to the enhanced methods.  We also believe that new methods should not be developed in an abstract way but in close interaction with real-life applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Tracing galaxy evolution with Nuclear Structures in Late-type galaxies' (TraNSLate) targeting Horizon Europe.

assistant: **Abstract**

Central regions of galaxies are inhabited by dense small structures, such as nuclear star clusters (NSCs) and nuclear disks and rings. These, at the bottom of the galactic potential well, are important tracers of the overall galaxy evolution, but the dominant mechanisms of their formation in galaxies of different masses and morphologies are still unclear. The TraNSLate project (Tracing galaxy evolution with Nuclear Structures in Late-type galaxies) will shed light on this issue, combining high-resolution zoom-in cosmological simulations with state-of-the-art integral-field spectroscopy observations. TraNSLate will be conclusive on the role of gas accretion and inflow followed by nuclear in-situ star formation, and stellar accretion and migration to the center of a galaxy. First, I will quantify the relative contribution of these processes in the central regions of 50 simulated galaxies. I will identify potential nuclear structures and unveil how they formed going back in time to previous snapshots of simulations. Secondly, I will focus on NSCs in observations of eight massive late-type galaxies (so far poorly studied), and their properties will be interpreted with the help of recipes provided by simulations. Finally, since higher resolution than current state of the art is needed to detect the smallest NSCs, TraNSLate will deliver one NSC-oriented pilot simulation, with a factor of 10 higher resolution, and a detailed plan for a future complete run of 20 more simulations. The TraNSLate project will be carried out at the Instituto de Astrofísica de Canarias under the supervision of Dr. C. Brook, expert on theoretical studies on the formation of galactic structures in a cosmological context. The theoretical expertise of the supervisor and the host research group is very c