RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of anandamide-synthesising pathways of primary sensory neurons in the development of pathological pain' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Pain associated with chronic peripheral pathologies is often intractable and, thereby negatively affects the quality of life of patients and places a huge financial burden on public health systems. Therefore, identifying novel efficacious ways to control pain is essential. N-arachidonoylethanolamine (anandamide) is a key signalling molecule which is produced by a major sub-population(s) of primary sensory neurons (PSN) following noxious stimulation or tissue damage. Exogenous anandamide, depending on concentration, duration of application and responsiveness of target molecules either inhibits or activates responses of a group of PSN, which plays a pivotal role in the initiation and maintenance of pain associated with peripheral pathologies. Further, our pilot data show that several enzymes implicated in anandamide synthesis are expressed in PSN in a cell-specific manner, suggesting that PSN-derived anandamide could induce responses in a pathway-specific fashion. Here, we aim to define the expression pattern of pathways and enzymes involved in anandamide production in PSN. Further, we aim to find changes in that expression pattern and activity of those enzymatic pathways by inflammation of peripheral tissues and injury to peripheral nerves. Finally, we aim to find the role of anandamide-synthesising pathways in the development of pain of inflammation and nerve injury origin. The Fellow will use cellular, molecular and behavioural approaches and broaden her technology repertoire by in vivo siRNA application, confocal immunofluorescent microscopy, microsurgery and analysing pain-related behaviour. Regulating anandamide levels in nPSN has previously been suggested for controlling nociceptive processing therefore anandamide-synthesising pathways in PSN are potentially target
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Solar-to-Chemical Energy Conversion with  Advanced Nitride Semiconductors' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

As photovoltaic technologies gain prominence, an outstanding challenge is the development of systems that can robustly store solar energy with high density. Within this context, the capture of sunlight and its direct conversion to chemical fuels in artificial photosystems provides a promising route for sustainably meeting future energy demands. However, a central challenge is the lack of systems that can efficiently direct light excitations towards desired chemical products with high efficiency and stability under harsh reaction conditions. In recent years, advances in using thin films to protect chemically sensitive light absorbers have relaxed the requirement for intrinsically stable semiconductors and motivate an entirely new perspective for rational design of materials and interfaces. Within this context, SECANS aims to create the scientific basis for solar-to-chemical devices that achieve unprecedented combinations of efficiency and stability, enabled by targeted exploration and rational optimization of an underexplored class of materials  transition metal nitride semiconductors. The electronic structures of these materials can enable a favourable balance between large charge carrier mobility and high defect tolerance. However, due to the high stability of molecular nitrogen, the expansive range of possible nitrides is largely unexplored and their basic properties poorly understood. SECANS overcomes these challenges through an interdisciplinary approach that couples non-equilibrium semiconductor deposition and newly developed interface engineering methods, supported by advanced operando spectroscopies, to enable high efficiency light harvesting systems with self-healing interfaces. This project will develop novel nitride semiconductors optimized for solar-to-chemic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Hierarchical Junction Solar Cells: Theory guides Experiements'.

assistant: **Objectives**

Light harvesting and the conversion of solar energy into other usable forms of energy is currently one of the most challenging topics on the field of renewable energy. Different possible scenarios exist to achieve this goal, some are based on solar thermal power and others on a variety of pathways for artificial photosynthesis. Perhaps the most promising approach is based on direct conversion of solar energy into electric current using photovoltaic cells. Needless to say, any significant advancement in cheap, accessible, photovoltaic technology will have a tremendous impact on the world energy economy. The overall goal of this proposal is to develop enabling technology needed to realize breakthrough photo-conversion efficiencies for nanostructured thin film photovoltaic systems. We will meet this goal through fundamental physical understanding of the kinetic and photo-physical processes involved in the conversion of solar radiation into useful electrical current for these systems. Building on this understanding will enable the development of new nanoscale materials, device structures, and interconnection schemes that will transcend the limitations of current devices providing for efficiencies to support new classes of all-inorganic solar cell devices. At the heart of the present program is the collaborative experimental (Berkeley host) - theoretical (PI) scientific effort. We believe that the field of renewable energy calls for such a close, fruitful, and fertilizing program. It will generate new ideas, thoughts, and directions required for a major paradigm shift in these systems. Furthermore, it will open novel directions for fundamental and applicable research for years to come.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Uncertainty and insecurity in europe' in the context of a Fifth Framework call.

assistant: **Objectives**

This project will explore uncertainty and insecurity (U&I) as crucial horizontal categories for understanding and anticipating public reaction to social and economic planning in four European countries (UK, France, Greece and Hungary). It addresses the problem of the vicious circle that increasing quality of life comes about through practices and policies that actually fuel and overall culture of U&I, which in its turn decreases quality of life. It aims to explain how U&I are constructed in contemporary Europe and to identify the effect that U&I have the life of European citizens and on their relationship with institutions of political and economic governance. Through extensive qualitative and quantitative research, cutting across six task areas, the project will bring together an interdisciplinary range of skills in the social sciences involving social theory, anthropology, political science and economic sociology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'The Development of Prenatal Screening in Europe : the past, the present and the future'.

assistant: **Innovation**

The purpose of this project is to identify the key ethical, legal and social aspects of developments in prenatal screening in order to inform public policies in the fields of public health and biomedicine. This three year project includes a series of studies to be carried out simultaneously in 4 member states, including Finland, Greece, Netherlands and UK.These studies entail overall mapping of individual countries' services as well as legal and ethical codes; extensive literature reviews of the popular press and professional journals; surveys of key players including experts, physicians and midwives and in-depth studies of lay people's views including groups of women's and/or families with experiences of pre-pregnancy or prenatal screening. The total study months are 233, while the total cost is 1017500 ECUS, a sum for which half (508750 ecu) is applied in this proposal.The unfolding of prenatal screening and the public awareness of this development provide a new framework for the perception of important ethical, legal and social issues.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Affirmative Post-Cinema: Narrative and Aesthetic Responses to Gender and Power'.

assistant: **Innovation**

The power dynamics and the effects of gender on social, spatial and political behaviour have regained major interest in public debates in the last years. If media (and new media) play an important role in relaying this debate, it does also in producing and reinforcing normative gendered practices. In response to the incapacity of mainstream media to induce effective change, video and digital artists explore the technological and political possibilities of digital media, video art and virtual reality to transform gendered norms affirmatively; that is creating alternative futures to the status quo rather than lamenting the current situation. Calling for a post-cinematic spectator, both individualised and participative, video and digital artists produce new genres and formats through which they express affirmative responses to gender and power. Building a bridge between film theory, new immersive media and social engagement, this research project will investigate how post-cinematic arts produce micropolitical instances of activism through narrative and aesthetic experiences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Tropical Rainforest-Atmosphere iNteractionS:Achieving a Coupled CLoud-Aerosol Interactions Model' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The main goal of this project is to characterize the amount of atmospheric aerosol particles formed, transported and deposited within deep convective clouds over the Amazon. In addition, we will quantify the impact of perturbations to the natural aerosol population on deep convective cloud properties. The European Union has in its 7th research framework program (FP7) recognized the need for increasing our knowledge of the interactions between the climate, biosphere, ecosystems and human activities. Aerosol-cloud interaction has also been identified by the Intergovernmental Panel on Climate Change (IPCC) as a key uncertainty in our current understanding of the climate system. Aerosol composition in the tropical environment is dominated by carbonaceous compounds. The sources of these compounds vary throughout the year, from oxidative processing of biogenic volatile organic gases during the clean, wet season to direct injection of biomass burning aerosols and organic gases in the polluted, dry season. By combining the experienced researcher’s in-depth knowledge of organic aerosol modeling with the aerosol and cloud expertise available in the host environment, we will develop the first cloud-resolving model to explicitly account for in-cloud organic aerosol formation, growth, and removal. The model will be able to simulate in detail the dynamical and microphysical evolution of a deep convective cloud, as well as the two-way interaction between the cloud and the atmospheric aerosol population. Using the new tool, together with upcoming and available in-situ measurements from different aircraft campaigns over the Amazon, we will increase the knowledge regarding the issues pointed out by FP7 and IPCC. We will also improve the description of aerosol-cloud interaction processes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Translation of adaptive optical microscopy expertise to the commercial domain' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Adaptive optics (AO) is an important technology for high-resolution microscopy that overcomes imaging problems when focusing inside biological specimens. Through the ERC Advanced Grant AdOMiS we have developed and experimentally validated new, broadly applicable AO tools that make integration of this technology more practical for a range of different microscopy techniques. We have also accumulated significant know-how about effective implementation of this technology. The challenge now is to translate these laboratory-based methods and know-how outside the academic research environment. This project will facilitate access to the products of our research to potential research and commercial adopters so that they can successfully deploy our AO methods in their systems.


**Keywords:** Optical microscopes, adaptive optics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New ergonomical hoists and slings by applying innovative concepts related to users and carers' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Although hoists have existed in the market for decades, and despite of the large number of models available attendants either require too much time to perform transfers effectively or suffer from excessive physical load, which may often lead to injury in the long run. Therefore they are reluctant to use these technical aids. On the other hand, users (elderly and disabled persons with severe mobility limitations) are not willing to accept hoists due to two main reasons: psychological stress (too much time is needed) and physical pain (high pressure areas occur). The project main objective is to develop new models of hoists with slings that make quick and smooth transfers possible without damaging attendants and disabled people. There is a high market demand for a new generation of hoists and slings that give comfort not only to disabled people but also to attendants. The principal industrial objective within this project is to develop such hoists and slings to meet the needs of their customers so that wider market acceptance is gained.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Drug DELIvery to the brain via CHOroid Plexus targeting' in the context of a Horizon Europe call.

assistant: **Objectives**

CNS disorders, e.g. brain cancer and Alzheimer’s disease, are the most common, debilitating, and underserved diseases. CNS drugs have historically suffered from considerably lower success rates during development than those for non-CNS indications. One of the major reasons is the presence of CNS barriers, including the blood-brain (BBB) and blood-cerebrospinal fluid (CSF) barrier. These blood-brain interfaces severely restrict the cerebral bioavailability of pharmaceutical compounds. While numerous attempts have been done to find methods to efficiently shuttle compounds over the BBB, less work has been done on blood-CSF crossers.Here, I hypothesize that targeting the blood-CSF barrier at the choroid plexus (ChP) is an attractive, innovative and underexplored strategy to deliver therapeutics to the brain.  Indeed, this CNS barrier forms a unique interface between blood and CSF and delivery of therapeutics across the ChP epithelial cells may offer added-value for the treatment of CNS diseases. Recently, we could show that the blood-CSF barrier, via hijacking the FOLR1 pathway, is indeed a novel and exciting entry site to deliver therapeutics to the brain. Proof of concept data convincingly show that our in house generated anti-FOLR1 single domain antibody (VHH) is able to deliver a peptide into the brain. Undoubtfully, further validating the use of this VHH as brain shuttle could have major therapeutic implications. Here, I aim to investigate: (1) which cargos can be shuttled into (specific regions of) the brain, (2) which neurological disorders might be targeted and (3) whether other RMT targets at the blood-CSF barrier have similar brain targeting capacity.This project will finally reveal whether the blood-CSF barrier is an interesting entry route to the brain with ther
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Role of Neuropeptides in Learning and Memory' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Humanity has always been intrigued by the nearly mythical properties of the brain. With its billions of neurons and innumerable connections, the brain is of such complex nature, that trying to understand it may seem a vain project. Yet, by using the ‘mini-brain’ of the model organism Caenorhabditis elegans, which shares many components with the human brain but counts only 302 neurons, thorough research can penetrate into this complexity. We here pursue to deliver a much-needed understanding of how learning and memory processes are regulated by neuropeptide signaling in the brain. Neuropeptides are small regulatory proteins that are implicated in a variety of processes. Growing evidence exists for their involvement in learning and memory, but how they exert these effects is largely unexplored. In C. elegans we recently disentangled a conserved vasopressin/ocytocin-related system that –as in humans– mediates associative learning. As such, we can deliver the experience, model and logical approach to provide detailed insights in neuropeptidergic control of learning and memory. We will first identify the endogenous ligand of all orphan C. elegans neuropeptide GPCRs, as this will provide the essential basis to build this project on. Mutants of neuropeptide-receptor pairs will then be tested for their ability to learn or maintain associative short- or long-term memory. We will also define in which cells and circuits relevant neuropeptides and receptors are needed for these functions, in order to generate models of neuropeptidergic control of learning and memory. We envisage the use of novel tools and cutting-edge experimental setups to take this research beyond its current horizon. Via single cell RNA sequencing, optogenetic analyses and in vivo calcium imaging, we will develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Assessing needs, quality of life, outcomes and cost-effectiveness of care for people severly disabled by schizophrenia in the EU' (1994-1998).

assistant: **Concept**

This proposal is a plan of research work over 3 years to (i) establish standardised European measures of service outcomes and costs for people with schizophrenia, (ii) use these measures in a multi-site study to evaluate services, (iii) disseminate these measures and the results of the study. The study sites are Amsterdam, Copenhagen, London, Santander and Verona.The work consists of 2 stages. In stage 1, the common standardised measures will be prepared for the study. In stage 2 these measures will be used in the five centres to study the outcomes and cost-effectiveness of services for representative samples of patients with schizophrenia (n=500).The study has 6 components :i To develop instrumentation. Specifically, we shall facilitate the development of short, reliable and valid measures of : needs assessment for the mental ill; family burden for relatives of the mentally ill; satisfaction with services by patients, relatives and staff; mental health service costs and mental health services utilisation.ii To obtain and compare data from 5 European sites about the quality and outcomes of care (in terms of symptom reduction, disability prevention, needs for care, care-giver burden, and patient satisfaction) under different systems of financing health care. Countries will be selected to represent a range of health care payment styles, and the results will reflect upon similar payments systems elsewhere, in the EU.iii To calculate and compare the total and component costs of care, including direct costs falling to health service agencies, and also the indirect costs borne by other agencies (social services housing, criminal justice), by families of people with schizophrenia, by sufferers themselves, and by the wider society; and so to compare the total economic consequen