RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Smart monitoring solution for better procurement and supply chain management - Speeding up chemical industry digitalization', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The global chemical industry is witnessing rapid changes in demand and leveraging digitalization to improve its operational efficiency has now become a vital need for the industry. Logistics is a key aspect of the chemical industry as production and consumption locations are mostly separated. Managing the supply chain has always been a major problem for the chemical industry. Companies work on tight margins and need constant monitoring of fill-level to ensure on-time product delivery and safety. The optimization of the logistics is the key factor which could differentiate one company from the other. However,chemical companies are stuck with the archaic fill level tank monitoring that blocks supply chain optimization and automation. To overcome the specific challenges, Nanolike created TankSensor,an IoT nanosensor and software solution for fill-level monitoring of industrial tanks. It creates network of the connected smart tanks, providing fill level and geolocation information remotely and in real time, enabling to plan, manage and optimise the supply chain. TankSensor is a non-invasive, easy to install Plug and Play device. It works for liquids,solids, gases and dangerous chemicals. It enables total visibility & control of chemicals fill levels improving stock management and eliminating risk of unexpected running out of stock. Our key customers are industrial sites, chemical suppliers and container manufacturers. The TankSensor uses our breakthrough, proprietary strain nanosensor to continuously monitor the fill-level of any container. It has been validated in tests with industrial chemical suppliers and has generated their strong interest. The project is well aligned with what we have done so far on nanosensor market, providing opportunity to scale-up our sales by rea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tracking interactions between RNA and RNA-binding proteins by thermal profiling of the proteome' to be submitted under Horizon 2020.

assistant: **Abstract**

RNA-binding proteins (RBPs) are among the key players in post-transcriptional gene regulation. A detailed knowledge of the RBPs bound to a specific RNA target is critical to the unravelling of the regulatory steps of RNA expression under normal and disease conditions. However, the study of these interactions is complex and requires methodologies that go beyond the scope of individual RBPs. So far, the techniques have been confined to post-lysis protein or RNA enrichment, which limits the identification of non-abundant targets and often relies on the insertion of tags.To solve these issues, thermal proteome profiling (TPP)—relying on the stabilisation of the endogenous protein through the binding of its ligand—will be applied in this project. Here, using mass spectrometry, TPP will be applied to investigate complex RBP-RNA interactions on a proteome-wide level in an unbiased manner ('meltRBP'). First, the methodology will be benchmarked with the help of a well-characterised interaction: the iron regulatory proteins and their RNA target, the iron response element (IRE). Secondly, TPP will be applied to a biologically relevant system, namely the mRNA of the Amyloid Beta Precursor Protein (APP). The proteolysis of mutant APP proteins, which are generated from alternatively spliced mRNAs, generates highly aggregation-prone β-amyloid peptides, a hallmark of Alzheimer’s disease (AD). The application of TPP to identify RBPs bound to the wild-type versus mutant APP mRNA will reveal new potential targets for AD treatment. Finally, TPP will be used to determine the specificity of the hybridisation of antisense oligonucleotides (ASOs), currently of great interest to the field of neurodegenerative disease treatment and whose global cellular effects have thus far not been investigate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced Training Environment for Crisis Scenarios' (PANDORA).

assistant: **Innovation**

Crisis management is a major issue to prevent emergency situations from turning into disasters. In last years a not correct management of emergencies often created critical situations. In the happening of a catastrophic event, it is human behaviour-- and often human behaviour alone--that determines the speed and efficacy of the crisis management efforts. Frequently speed and efficacy do not stem from the ignorance of procedures, but from the difficulty to operate in contexts where consistent damages are occurring, for the difficulty of managing emotional aspects. Training plays an important function to the preparation of the crisis manager. Currently two main modalities for training purpose are two: table top exercise and real world simulation exercise. Table top exercises are low cost and can be easily and frequently organized, but it cannot recreate the real atmosphere, (e.g. stress, confusion) and need to keep critical decisions in very little time. On the other hand, crisis managers trained through simulation exercises on the field can be very effective, but such a simulations are very expensive and cannot be easily and quickly organized. PANDORA will bridge the gap between table-top exercises and real world simulation exercises, providing a near-real training environment at affordable cost. In a real-time, physics-based environment, PANDORA authentically simulates all the dynamic elements of the entire disaster environment. PANDORA will emulate a complete crisis room: realistic 3D visuals and audio create a truly immersive, chaotic and stressful environment. PANDORA realistically responds to actions taken to enable real individual training value and the development of complete skill sets. Pandora will train at all levels of response, from management and control to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Exploiting Therapy-Induced Neo-Epitopes to Overcome Drug Resistance in Triple-Negative Breast Cancer' (TI-uORFe) targeting Horizon Europe.

assistant: **Abstract**

Therapy-induced neo-antigens represent a novel class of tumor-specific antigens that arise from therapeutic interventions such as chemotherapy and targeted therapies. These neo-antigens, resulting from genomic mutations, aberrant post-translational modifications, and dysregulated RNA splicing, are recognized by the immune system as foreign, prompting an immune response that bypasses central tolerance mechanisms. Despite advancements in next-generation sequencing and bioinformatics that facilitate the identification of these neo-antigens, distinguishing drug-induced neo-antigens from inherent tumor antigens remains a significant challenge. This proof-of-concept proposal aims to leverage therapy-induced neo-antigens to develop personalized cancer vaccines and immunotherapies, particularly targeting triple-negative breast cancer (TNBC), where drug resistance is prevalent.By utilizing ribosome profiling, we have identified non-canonical peptides translated from therapy-induced changes in cancer cells, which are presented by MHC-I molecules and recognized by T lymphocytes, leading to specific tumor cell killing. Our approach focuses on generating mRNA vaccines based on these neo-epitopes, with the goal of enhancing chemotherapy responses and overcoming drug resistance. The proposed research will address critical bottlenecks in neo-epitope therapy, including accurate identification of immunogenic neo-epitopes and validation of immunogenicity in preclinical models. Ultimately, this innovative strategy aims to improve therapeutic efficacy and patient outcomes in TNBC, offering a transformative approach to combat drug resistance and enhance survival rates.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MICROWINE - Microbial metagenomics and the modern wine industry' to be submitted under Horizon 2020.

assistant: **Abstract**

A diverse, complex, and poorly characterised community of microorganisms lies at the heart of the wine – an industry worth over €220 billion globally. These microorganisms play key roles at all stages of the viniculture and vinification processes, from helping plants access nutrients from the soil, driving their health through protection against pathogens, to fermentation processes that transform the must into wine with its complex array of aromas and flavours. Given this importance, an improved understanding of the microbial community and its interplay will have significant effects on the industry. In recent years, 'Next Generation' DNA sequencing has revolutionised many areas of biology, including microbiology, through conferring the ability to characterise microbes on the deep community scale, through both ’shotgun’ and ’deep amplicon’ sequencing approaches. To exploit this power for the benefit of the wine industry, we propose MICROWINE, a 15 ESR Marie Curie Actions European Training Network. The network is constructed as a close collaboration between industry and academic partners, around the theme of the microbial community’s role in the wine production process. Through combining microbial metagenomic sequencing with powerful computation analyses, with metadata generated using techniques such as metabolomics and geochemistry, we will study the action of microbes from the plant protection and nutrition, through to wine fermentation process, using samples collected from both Europe and beyond. We will further train the ESRs across a wide range of relevant disciplines, and maximise information transfer through multiple host and academic-industry cosupervision and secondments. In this way, we anticipate contributing to the strength and scientific progress of the wine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Social software for inclusion of (marginalized) young people' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

INCLUSO aims to deliver verifiable proof that ICT, and more precisely, social software tools, can facilitate social inclusion of marginalized young people.  INCLUSO will make suggestions for future research and development, based on desk research, expert input, pilot projects in 4 countries, the development of a measurement tool to screen evolution in social inclusion/exclusion and a business and sustainability model for organizations working with ICT in the area of social inclusion. <br/>The pilot projects will be initiated in strong, existing organizations with or no experience in the use of social software, but already working with marginalized youngsters and with a high potential to succeed in successful ICT implementation. 4 pilots will focus on complementary groups of youngsters <br/>(1) young people that are all subject of the Flemish 'Special Youth Assistance'-act or the Belgian 'Child Protection,  located in Brussels (BE);<br/>(2) socially excluded youngsters in city area of Aberdeen (UK);<br/>(3) young people from day-care of full-time-care institutions described in the Social Service Act (PL)<br/>(4) young people recruited by social workers and street-workers who are in contact wit marginalised and disadvantaged youngsters in the city of Schwechat (AT)<br/>Social software tools will be introduced as an empowering tool for inclusion in general and, more specific, to meet the participating organizations' goals. <br/>Feedback from the pilots will enhance the white-book that presents implementation scenarios for ICT as a tool for social inclusion. Pilot feedback will also strengthen the business and sustainability models and the measurement tool tat screens social inclusion/exclusion. <br/>The partnership is a strong combination of organizations working with marg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Construction of a new drosophila delection collection & a european drosophila network' (DROSDEL), addressing dissemination and exploitation.

assistant: **Impact**

The objectives of this proposal are (I) to develop new stocks of wide utility to researchers in Member States. These stocks will enhance the power of Drosophilae genetics and, in particular, provide tools for the functional analysis of the Drosophilae genome. (ii) To provide opportunities for the European Drosophilae Research Community to meet in a network, which will develop the cohesiveness and interaction within the Community research. The major components of this Project are by far best carried out at the Community level, since it is to provide a core infrastructure resource that must be available to, and will be used by, the entire EuropeanDrosophila research community, which is estimated to comprise 2000 researchers. The relevance of this Project comes from the fact that extensive research with the Drosophilae model in Europe's in the forefront of the new field of functional genomic, and that Drosophilae comprises a field of increasing importance to biomedical research in general. This project will contribute to European competitiveness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'TRANSFER OF COMPUTERISED AGRO PREWARNING SYSTEMS TO THE SOUTH EUROPEAN ENVIRONMENT' (1994-1998).

assistant: **Innovation**

Based on detailed Microclimate Data collection, computerised pre-warning systems have been developed which ensure efficient and ecologically sound crop protection. Solar powered radio weather stations collect microclimate data and transfer it to a receiver. Each station can transmit and receive within a radius of up to 20 km so that large radio networks can be erected quickly and economically. The transferred data includes typically relative humidity, temperature, precipitation and leaf wetness. Optionally wind speed and direction, soil moisture and temperature, air pressure and further meteorological sensors can be integrated. The individual micro climate conditions are transmitted (every 15 min.) to a central data base for evaluation and analysis.Using this Database agricultural expert systems have been developed to allow early detection of crop diseases. The systems are based on microclimate conditions and take into account growth rates, crop treatment and environmental conditions. Potential diseases are thus detected early allowing focused usage of crop protection.Expert systems are now available for wine, fruit, potato and sugarbeet. Reference networks exist in the German speaking countries and Scandinavia.The aim of the TOCAP project was to adapt the expert systems to crops (fruits, vegetables, etc.) and diseases of southern European countries. In order to achieve this goal medium sized test networks with solar-radio weather stations were installed in Italy and Spain. Prototype networks were specified by the end users, which typically were larger agricultural companies, associations, co-operatives and local government. Once the environmental data had been analysed new expert systems were adapted to the requirements of southern European crops and implemented throug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Enhancement of electroluminescence in polymers-from molecules to materials'.

assistant: **Concept**

Research objectives and content The research project has two specific objectives, viz. the development of a range of blue light emitting polymers and improvement of polymer luminescence efficiency by control of polymer processing and order. Some elements of the project fall) within control of order on the molecular scale; others rest on control of the meso scale. (i) New Materials With Light Output at Short Wavelength New solvent-processible conjugated polymers carrying sterically bulky substituents, which will reduce coplanarity and hence favour a blue-shifted emission, will be synthesized by dehydrohalogenation and organometallic cross-coupling reactions. (ii) Exploration of Improved Solvent Processibility in Hydrophilic Solvents It is considered advantageous to be able to build up polymer layers by deposition of a polymer from a solvent which will not dissolve the previously deposited polymer layer. Layer-by-layer deposition of polyionic materials should also also exceptionally thin devices to be fabricated. For this purpose an environmentally benign solvent such as water is attractive Polyionic species soluble in water will be prepared by polymer-analogous alkylation reactions. (iii) Enhancement of PL Efficiency by Blends of Luminescent Materials in a Semiconductive Polymer Host Layer. The objective is to gain control of macroscopic ordering in copolymers by the design and synthesis of polymeric material which are compatible as polymer blends. Training content (objective, benefit and expected impact) The group is well equipped to provide a suitable training ground for a postdoctoral investigator. The research group provides; stimulating environment for polymer synthesis. Control of polymer architecture is one of the key research themes spanning stereoregular polymer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Temporal predictions in the auditory cortex: neural mechanisms and their specificity across species and stimulus domains' (BrainPredictDynamics), addressing dissemination and exploitation.

assistant: **Impact**

Following a recent paradigm shift in neuroscience, the brain is often thought to generate active predictions of its environment. Neural predictions of temporal information, in particular, are a current research frontier. A key challenge is to provide a unifying mechanistic explanation of neural expectations ranging from microscopic electrophysiology, via models of interacting populations of neurons, to macroscopic signals observed non-invasively. Auditory and speech perception are the optimal testing ground for studying temporal dynamics of predictive processing in the brain, as most auditory signals only gain meaning as temporal sequences. This project aims at (1) providing a mechanistic model explaining how temporal expectations influence neural activity in auditory cortex across species (rats and humans), and (2) test whether the mechanisms established for simple auditory stimuli generalise to rich, complex and hierarchical structures characteristic of speech stimuli. These research objectives will be addressed in a coherent programme based on well-controlled psychoacoustic and psycholinguistic experiments, combining extracellular electrophysiology in rats and neuroimaging (magneto- and encephalography) in humans with novel analytic tools. By integrating knowledge from disparate fields such as systems-level neuroscience and psycholinguistics, the project will yield novel and unique evidence testing the generality (across species and stimulus domains) and specificity (regarding the proposed neural mechanisms) of the influential theories construing the brain as an inherently predictive organ. Besides its immediate research objectives, the current project is optimised to provide me with training necessary to reach professional independence, complementing my interdiscipl