RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Smart Clothing Gamification to promote Energy-related Behaviours among Adolescents' in the context of a Horizon 2020 call.

assistant: **Objectives**

Energy-related behaviours (physical activity, sedentary behaviour) are main modifiable determinants of several non-communicable health conditions, e.g. diabetes type 2, overweight and obesity, and track into adulthood. Promoting these behaviours among youngsters can have great health and societal gains. Meeting recommended levels for these behaviours is especially low among adolescents, girls and those of lower socio-economic status. An intervention to promote energy-related behaviours among adolescents is thus indicated, and may also address social inclusion. Exergames, which require movement to be played, have great yet underused potential to promote these behaviours. To fully utilise this potential, exergames need to promote moderate-to-vigorous physical activity; need to be tailored to the individual user; and need to be more engaging. The SmartLife project aims to create such an exergame. The SmartLife exergame will be: 1) a mobile game requiring lower body movements; 2) combined with a smart textile that provides immediate physiological feedback (e.g. heartrate, respiration) and ensures exercises are performed at a moderate-to-vigorous intensity level; 3) tailored to individual user’s needs, using the smart textile data, and based on available evidence and big data analysis; 4) highly engaging, e.g. by adding a narrative and context information, and using user input throughout the design (‘participatory development’). The project includes extensive testing and dissemination of results. Market analysis will explore commercial business opportunities (e.g. technology-based connected health) and social marketing opportunities (e.g. via schools). The SmartLife project proposes a technological innovation via integration of exergames and smart textiles, to optimally reac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Ultrafast Imaging of the Heart Using Ultrasound: a breakthrough for early diagnosis of cardiac diseases'.

assistant: **Innovation**

Heart failure (HF) affects 14 million people in Europe, and this number is forecast to increase to 30 million by 2020. Early diagnosis of HF is essential for successfully addressing underlying causes. However, initial diagnosis is difficult in many situations so that HF is correctly diagnosed in only half of affected patients. Diastolic HF, for example, that accounts for more than 50% of all HF patients, is due to abnormal ventricular stiffness which remains very difficult to diagnose. The characterization of myocardial properties remains today a challenge and there is currently no imaging technique that can assess myocardial stiffness in clinical practice.In ULTRAECHOCARDIO, a novel ultrafast imaging approach is proposed not only to image myocardial stiffness but also myocardial electromechanical properties and blood flows with high sensitivity. Whereas conventional ultrasound scanners can achieve 100 images/s, ultrafast imaging can perform 100 times faster, up to 10,000 images/s. This ultrafast capability is a breakthrough in cardiac imaging that opens new possibilities, such as imaging tissue and blood motion with high temporal resolution, but also mechanical (shear waves) and electromechanical waves that remain undetectable with conventional techniques. New echocardiographic modalities will be developed based on a unique ultrafast imaging platform: (1) Shear Wave Imaging for quantitative evaluation of myocardial stiffness, (2) Electromechanical Wave Imaging for mapping of electrical activation in the heart and (3) Ultrafast Doppler Imaging for blood flow mapping with high sensitivity. These modalities will be validated on preclinical models with early modifications of myocardial stiffness and electrical disorders. Finally, the clinical impact will be evaluated on pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Alzheimers Disease Apolipoprotein Pathology for Treatment Elucidation and Development - Sofia ref.: 115975' in the context of a Horizon 2020 call.

assistant: **Objectives**

APOEɛ4 has long been known as a risk factor of LOAD, yet the biological mechanisms through which it acts remain largely unknown and affect both the vasculature and the brain. This complexity and pleiotropic influence demands an integrated hypothesis-free approach to embark on a fundamental study of the gene, the phenotype and modulation by other risk factors. ADAPTED proposes to leverage extreme genotypes from consortium cohorts dating back more than 25 years to generate, and use existing, lines of human induced pluripotent stem cells (iPSC). These cells, with blood cells, will form the backbone of the research programme. We will differentiate them to the most relevant cells for APOE and AD studies and with gene editing create bespoke homozygote ɛ3 and ɛ2 cells for a highly focussed effort on APOE biology. A series of experiments including neuron-astrocyte and macrophage-endothelium co-culture and Organ on a Chip models combined with state-of-the-art omics including quantitative proteomics assays will generate data for rigorous integrated analysis to uncover new signalling pathways related to APOE. Lipid homeostasis, endocytosis, metabolism and immune systems pathways will be investigated in a broad approach. The findings are expected to lead to identification of new treatment approaches and blood based AD signatures with a temporal dimension from the earliest stages of risk identification and progression through MCI to AD. Testing and validation of biomarkers will be performed by examining their influence and predictive capacity in a longitudinal ADAPTED cohort harmonised using a combination of approaches for marker and diagnostic consistency. The impact of this work can be expected to include seminal new finding to illuminate the research path towards new diagnostics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Phthalocyanine-biopolymeric nanoparticle delivery systems for cancer photodynamic therapy'.

assistant: **Concept**

According to the World Health Organization cancer was responsible for approximated 9.6 million deaths in 2018 what is the reason of being one of the biggest civilizational health problem, just behind the heart diseases. The global objective of interdisciplinary BIOnanoPDT project is to develop novel biodegradable phthalocyanine (Pc)-polymeric nanoparticles (NPs) which enhance cancer photodynamic therapy (PDT).Up to now, there is no ideal therapy for cancer treatment but among the others PDT presents several advantages, e.g. it is a selective treatment with less secondary effects than other therapies. This promising therapy combines three components: photosensitizer (PS), light and oxygen. 20 years ago PDT was approved by Food and Drug Admnistration as a clinical protocol for cancer treatment but it still have limitations to use it in all types of cancer. The development of new powerful PSs, which specifically target cancer cells, and can more deeply penetrate tissue allowing to treat large tumors is still a challenge.Phthalocyanines (Pcs) are one of the most promising second generation PSs and meet many requirements for being ideal PSs. Unfortunately, very often Pcs are hydrophobic species and undergo self-aggregation in aqueous solutions, which drastically reduces their photosensitizing efficiency. In BIOnanoPDT project the limitations of Pcs will be overcame by tailoring their properties in terms of singlet oxygen generation and by incorporating them with polymer NPs which could improve their photophysical properties, selectivity for targeted tissues by surface modification, eliminate aggregation of the PSs and their low water solubility. Additionally, it can enhance the treatment by increasing the blood circulation and selective accumulation in tumor cells.The BIOnan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'How antibodies and complement orchestrate protective  immune responses against bacteria' (ACCENT).

assistant: **Innovation**

Due to antibiotic resistance, there is now great interest in the development of antibody-based therapies against bacterial infections, for instance via antibodies that boost the host immune system. In order to kill bacteria, antibodies should trigger activation of the complement cascade, which forms bactericidal Membrane Attack Complex (MAC) pores and strongly enhances phagocytosis. Although the power of complement could be exploited for antibody therapies, such developments are hampered by our limited insights into the mechanisms underlying antibody-dependent complement activation on bacteria. My team has developed unique assays to study complement activation on bacteria. In this proposal, we will combine our function-driven approaches with novel B cell sequencing methods to identify anti-bacterial antibodies with strong complement-activating potential. We will develop novel approaches to identify the variable (VH:VL) sequences of human antibodies that recognize whole bacterial cells. After FACS sorting of memory B cells or yeast Fab display, we will use multi-well functional assays to select monoclonal antibodies driving potent complement activation and subsequent killing of E. coli (via neutrophils or MAC). Thanks to our unique tools and unprecedented insights, we are in an unique position to decipher basic mechanisms by which antibodies induce bacterial killing via neutrophils or MAC. We will combine live-cell imaging and structural approaches to determine how bactericidal antibodies assemble lethal MAC pores in the bacterial cell envelope. Finally, we will explore the design of potent antibody combinations and study the mechanisms by which antibodies steer different effector functions, both in the context of clinical and non-pathogenic E. coli strains. Altogether,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Environmental impact assessment of transgenic grapevines and plums on the diversity and dynamics of virus populations' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Our proposal addresses environmental safety issues of transgenic plants expressing virus-derived genes. Our main objective is to evaluate under field conditions the incidence of coat protein genes in transgenic grapevines and plums on the dynamics and variability of virus populations, particularly on the development of viable recombinant viruses with potential harmful properties. We will also assess whether transgenic plants present additional risks compared to non-transgenic plants, examine if heterogonous viruses can revert post-transcriptional gene silencing in plums, and analyse if transgenic transcripts can translocation from transgenic rootstocks to non-transgenic scions in grapevines. Identifying potential risks and assessing their impact is the safest approach to protect the environment prior to the release of virus-resistant transgenic crops.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Determining the system parameters of low mass X-ray binaries' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Low mass X-ray binaries are two gravitationally bound stars where the secondary is a normal solar type like star and the primary a compact object, i.e. a black hole or neutron star. Matter is transferred from the secondary, thereby forming an accretion disk around the compact object that gives rise to the X-rays. These systems are excellent laboratories to test several theories, including stellar evolution, theory of accretion and the theory of relativity. However, accurate measurements of the masses of the two components in these binaries are necessary to test these theories, and that has been complicated since the secondary is many magnitudes fainter than the accretion disk around the compact object. We propose a new technique to measure the masses more accurately than has been possible thus far. Recent observations have shown that a signature of the secondary is present in certain fluorescence lines, in particular the Bowen fluorescence lines around 4640 Angstroms. Furthermore, the observed optical emission is mainly due to reprocessing of the X-rays, and any variability observed in the X-rays should also be present in the optical, but delayed with a few seconds depending on the reprocessing time and distance of the optical site compared to that of the X-rays. Simultaneous high temporal X-ray and optical observations, either narrow band photometry or spectroscopy, should be able to measure the delay in the fluorescence lines coming from the donor, and thereby constrain the system parameters of low mass X-ray binaries. For the optical observations however, large 10 m class telescopes with high timing capabilities will be necessary, and these will become available early 2009 in the form of GranteCan. Here we ask for the grant to have  minor adjustments to the instrumen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pathways to(wards) carbon neutrality for climate, environment, health and socio-economic co-benefits (PANTHEON)' (PANTHEON).

assistant: **Concept**

Pathways to(wards) carbon neutrality for climate, environment, health and socio-economic co-benefits (PANTHEON) offers a participatory integrated modeling approach, developed via an iterative, co-learning process among researchers, private and public stakeholders, to assess how different mature and future (TRL4) technologies in crucial economic and energy sectors can be morphed into successful (economically, socially and environmentally sustainable), joint decarbonization pathways. The kernel of the project is a two-tier innovative integrated assessment modelling framework that reconciles I) goals for improving energy efficiencies & decarbonization along the supply chain, with ii) socio-economic impacts and challenges (including health and labour); and iii) insights from informed stakeholders’ deliberations on a granular level (national-regional-sectoral-firm public stakeholders, and stakeholders from sectors along the global supply chain.


**Keywords:** participatory modelling,  stakeholder engagement,  integrated assessment modeling,  MRIO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Developing Rapid Inquiry as a pedagogical framework for multimodal interactions in informal science settings' (SCIENCE-MINQ) under Horizon 2020.

assistant: **Objectives**

This project is firmly situated within the Learning Sciences – the interdisciplinary field that aims to further scientific understanding of learning and engage in the design and implementation of learning innovations; focusing on the area of Informal Science Learning – the study of science learning processes and outcomes in informal settings such as science centres.Bell et al. argue that a key challenge for science centres is to enable their visitors to link their emotional, sensory and cognitive interactions with the exhibits – known as multimodal experiences – to science-specific phenomena. This research aims to utilise the structure provided by inquiry-led scientific investigations to harness the engagement power of multimodal exhibits in science centres. To achieve this aim, we will work with science centre educators, science teachers and young people (aged 12-16) to: co-design a Rapid Inquiry framework; elicit user requirements; co-design interaction components that integrate multimodal interactions with exhibits; develop an Inquirer app and evaluate its impact; and develop a set of technical requirements and pedagogical guidelines that will enable science centres to adopt rapid multimodal inquiry as a pedagogical approach. Partnerships with science centres in the UK, local secondary schools and after-school science clubs will be established to secure maximum practical value and dissemination.


**Keywords:** science centres, science learning, informal learning, inquiry learning, multimodal learning, pedagogy, mobile learning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Myelinic nanochannels in neurodegenerative diseases' in the context of a Horizon 2020 call.

assistant: **Objectives**

Myelin is made by highly specialized glial cells and enables fast axonal impulse propagation. We havediscovered that oligodendrocytes in the CNS are, in addition to myelination, required for the integrity andsurvival of axons, independent of the presence or absence of myelin itself. More recently, we found theunderlying mechanism and could show that glycolytic oligodendrocytes provide axons with pyruvate/lactate.These metabolites are transported through a system of myelinic nanochannels to the axonal compartment, inwhich mitochondria generate ATP. The finding was a paradigm-shift for the physiological function of axonassociatedglia, and opens now the intriguing possibility that oligodendrocytes are important modifiers ofneurological diseases in which myelinated axons are lost. This includes, in addition to multiple sclerosis, alsoclassical neuropsychiatric disorders. We will generate novel genetic tools in mice that allow us to study therole myelin and secondary axonal loss in higher brain functions. We will test the challenging hypothesis thatreducing oligodendroglial support of axonal metabolism is a risk for differen neurodegenerative disorders.These involve the previously neglected ultrastructure of CNS myelin with cytosolic (20-300 nanometerwide) channels within the myelin sheath. These 'nanochannels' couple the oligodendrocyte somametabolically to the adaxonal space, but are vulnerable to aging and physical injury. We hypothesize thatcellular mechanisms as diverse as neuroinflammation and the aggregation of misfolded proteins in myelinicnanochannels cause perturbations of the axonal energy metabolism. When combined, the findings ofMyeliNANO will shed new light on previously unknown functions of CNS myelin and will pave the way formetabolic neuroprotection as a the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European Initiative for Basic Research in Microbiology and Infectious Diseases' (EIMID).

assistant: **Innovation**

By initially building a strong coalition among five European centres of excellence, the objectives of EIMID are to reach a critical mass on relevant microbiology topics; to allow rapid and effective scientific reaction to emerging problems; to foster exchange of scientists; to improve the visibility of Microbiology and Infectious Diseases as a discipline of key importance in Europe; to attract the best fellows and post-docs to the area; to counter the current brain drain of young European investigators to USA.  In this context, a consortium will come together, composed of the small Italian company ALTA, the Max Planck Institute for Infection Biology in Berlin, the Centre for Molecular Microbiology and Infection at Imperial College London, the Institut Pasteur in Paris, the Karolinska Institutet in Stockholm, and the vaccine company Chiron in Siena. The consortium will organise a 3-year PhD training programme for fellows who will visit different EIMID centres. Interdisciplinarity and academic-industrial cooperation will be emphasized. Ten fellows will follow an individual training pathway in the areas of host-pathogen interaction and novel strategies for designing vaccines and inhibitors. Parallel training aimed at improving complementary skills will implement the fellows' future role in the global scientific world.