RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Artificial Intelligent Dentistry for cost-efficient X-ray analysis and diagnosis'.

assistant: **Innovation**

Promaton has built the first of its kind fully automated 2D and 3D X-ray analysis and diagnosis solutions. These Artificial Intelligent Dentistry (AID) solutions significantly  reduce labour time and costs of dentists. They speed up tasks of dentist, such as X-ray data cleaning, annotation, segmentation, classification and detection of dental structures and diseases with 90%. Competitors’ offerings require annually on the average as much as 18 days of work or €29,000 in labour costs per dentist more. Promaton aims to penetrate first the French, Benelux and Southern Europe dental analysis and diagnosis markets before scaling up to the German and the American markets. It expects to achieve at least a 2% share of the €2b dental X-ray analysis and diagnosis market and to have grown to more than 200 employees by 2027. Thereto, it proposes large manufacturers to integrate its AID solutions with their own software and hardware platforms for dental X-ray analysis and diagnosis and license the AID solutions at €500 per year per client (being practice or dental clinic). In return, these manufacturers are allowed to white label, co-brand, and license the integrated AID solutions to their client base at their own convenient price points. Asking more than €1,000 per dental practice per year, Promaton’s competitors are expected to phase themselves out quickly. During the AID project, Promaton will validate its value proposition and business model (based on fixed or per analysis-diagnosis fee) with Benelux, French and Southern Europe strategic partners. It will benchmark competitive and alternative solutions, consulting renowned members from medical industry and science. It will consolidate the project results in a viable business plan for industrialization of its DL-based innovations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'POLAR BEAR RESPONSE TO GLOBAL WARMING: Insights from shotgun sequencing of the Polar Bear Genome' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The polar bear (Ursus maritimus) is the top predator of the northern hemisphere polar regions and the human iconic symbol of the Arctic and climate change itself. Due to projections of accelerated global environmental changes leading to dramatic reductions in range size over the next 50–100 years, global warming is believed to be the most important long-term threat to the polar bear’s future survival. However, these current projections are based on short-term ecological, behavioural, and genetic studies, and no scientific studies exist that directly quantify the effect of climate-induced environmental changes on the species. This study will apply novel shotgun sequencing methods to build a genome-wide SNP (single nucleotide polymorphism) library of the polar bear genome, initially using modern populations, and subsequently transferring these methods to subfossil samples. By projecting the temporal genetic data against precise estimates of past climatic events derived from Arctic ice and lake cores, we will be able to estimate the precise timing, duration, and effects of past demographic changes. By understanding the significance of how environmental perturbations affected the species in the past, the first informed predictions can be made of how polar bears, and ultimately other Arctic marine mammals, will respond to the ongoing global warming that is threatening their ecosystem. This study will generate the first population genomic dataset of its kind, using both ancient and modern samples. The refinement of current laboratory methods and the development of analytical methods during the statistical analysis of the data will significantly contribute to the fields of evolutionary genetics and ancient DNA. In addition, the study will make an important contribution to pola
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'BioExcel Centre of Excellence for ComputationalBiomolecular Research', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Life Sciences have become increasingly digital and this is accelerating. Computational techniques play key roles in processing, analysis and generating new knowledge from experiments, even in replacing them. This has been enabled due to tremendous advances in techniques such as docking and molecular simulations at both atomistic and quantum levels to which world-leading European research and software are contributing. Pushing computational capabilities towards Exascale will advance the area, enabling researchers to tackle increasingly complex questions related to biomolecules' function, mechanisms, dynamics and interactions. This will impact on our daily life, in health, for the development of new drugs and efficient drug delivery methods, in biotechnology, environment, agriculture, food industry and education. To exploit this great computational power, in academia and industry, significant efforts on software efficiency, scaling, usability and education are needed. This is the mission of the BioExcel Centre of Excellence for Computational Biomolecular Research launched in 2015 with EC support. It has made significant contributions by focusing on highest-impact European codes, workflows and an extensive, international education program. BioExcel-2 will continue and expand this work, with a focus on Exascale impact, improved usability, expanded training and commercial applications, while strengthening its user-driven governance. Specifically it will: * Push performance, efficiency, scalability and usability of the selected software packages towards Exascale in a co-design manner, contributing to the EuroHPC vision * Support convergence of HPC, HTC, and HPDA with workflows combining simulations with data management and analytics * Support and enlarge the user community by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Linking Ketone Metabolism and Signaling in Heart Failure with Preserved Ejection Fraction' under Horizon Europe.

assistant: **Concept**

Heart failure with preserved ejection fraction (HFpEF) is a burgeoning public health problem for which there are little to no evidence-based therapies. This syndrome has proven particularly challenging because of the limited insight into its underlying molecular mechanisms. Metabolic adaptations are critical for cardiomyocyte response to stress. Ketones are metabolites actively produced in heart failure and their role as metabolic rheostat capable of modulating cardiac metabolism and cardiomyocyte signaling pathways has been postulated. However, there is fundamental, open gap in understanding how ketones are utilized as source of energy in HFpEF and how -hydroxybutyrate (-OHB)  the most abundant ketone  plays a role as non-energy carrier governing cardiomyocyte function. In this project proposal, I hypothesize that ketones are major regulators of cardiomyocyte biology representing an alternative source of fuel in HFpEF (energy role) and act as protein modifiers trough -hydroxybutyrylation  a lysine-based post-translational modification (PTM)  thereby regulating chromatin architecture, gene transcription and metabolic signaling in cardiomyocytes (non-energy role). The overall aim of KetoCardio is to define mechanisms integrating ketone metabolic adaptation with signaling pathways and epigenetic changes in HFpEF-stressed cardiomyocyte. Coupling proteomics, transcriptomics and genomics approaches together with cardiac and systemic metabolic evaluation and rigorous preclinical experimental modeling of HFpEF, I will be able to define the previously unrecognized role(s) of ketones as energy substrates in HFpEF and as substrate for proteins PTM impacting on cardiomyocyte function. In summary, focusing on metabolic pathways that govern cardiomyocyte abnormalities in preclinical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Exhibition Stands At: OTC Houston, May 2000 & 2001, EAGE, May/June 2000 & 2001; ONS Stavanger, August 2000; PREGO Egy'.

assistant: **Objectives**

To promote and increase the uptake of EC funded hydrocarbon technologies, which have the potential to solve current and future exploration, extraction and production challenges facing the oil industry. To identify and promote previously unknown technologies which are being developed by SMEs to meet the oil industry's current and future challenges. SMEs are responsible for much of the innovative technology in the hydrocarbons industry. To promote the 5th Framework Programme and its role in the EU energy strategy to industry, and government policy makers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'The implementation of advanced computer tech. and R.P. into product development for the ceramics industry'.

assistant: **Objectives**

THE RAPID DEVELOPMENT OF MACHINE AND COMPUTER TECHNOLOGY HAS LEFT MANY PARTS OF THE CERAMICS INDUSTRY BEHIND. COMPANIES WITHIN THE INDUSTRY RECOGNISE THIS SHORTFALL BUT ARE UNABLE TO AFFORD THE RESEARCH INTO THE TECHNOLOGY DUE TO THEIR SIZE. THE RESEARCH AIMS TO COVER: 1. THE REDUCTION IN LEAD TIMES DUE TO IMPLEMENTATION OF NEW TECHNOLOGY 2. DEVELOPMENT OF METHODOLOGY 3. OPTIMUM METHODS OF DATA TRANSFER 4. INTEGRATION OF RP AND RM INTO A CERAMICS INDUSTRIAL ENVIRONMENT 5. IMPROVE COMPETITION WITH OVERSEAS MARKETS IE: USA, JAPAN 6. IDENTIFY CORRECT LEVEL OF INTRODUCTION
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cryptography for Second Layer Blockchain Protocols' to be submitted under Horizon Europe.

assistant: **Abstract**

Blockchain technologies offer an exciting new alternative for centralized platform providers. They distribute trust over a large number of parties, thereby promising major benefits in terms of security, freedom and efficiency. Unfortunately, due to their inherent distributed nature, state of the art blockchains suffer from a multitude of shortcomings. In contrast to centralized platforms, they are restricted in terms of scalability, confidentiality and functionality, and thus cannot power large scale applications. The ambitious goal of CRYPTOLAYER is to overcome this situation by building decentralized systems that can compete with centralized platforms. We will achieve this goal via building off-chain technologies that form a secure second protocol layer on top of the underlying blockchain. The first component of CRYPTOLAYER builds a family of secure protocols for off-chain transaction systems. These protocols move the massive amount of transactions to a second layer, thereby offering nearly unlimited scalability and instantaneous transaction processing. Our solutions will support smart contracts - complex programs that can handle money - and offer strong privacy guarantees by relying on tools from cryptography.  The second component of CRYPTOLAYER leverages advanced cryptographic building blocks to construct secure off-chain services for confidentiality and access to real-world data. This will enable rich classes of applications to run over decentralized infrastructures. Finally, since secure protocol design is highly involved and error-prone, we will build upon the formal framework of theoretical cryptography. We will develop formal security models using the universal composability framework, and carry out a rigorous security analysis using mathematical proofs. With
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Platform-aware LArge-scale Time-Series prOcessiNg' (PLATON).

assistant: **Concept**

PLATON brings together a highly-experienced researcher in the field of the theory of concurrent and distributed computing with a hosting group which has world-leading expertise on data series management, indexing, and analysis to harness the difficulties of large-scale data series processing by realising the data series processing performance and scalability goals. Specifically, PLATON aspires to build the necessary methods, algorithms and tools for highly-scalable and fault-tolerant processing of huge collections of data series by exploiting, for the first time, the full computational capacity (multiple nodes, multiple cores, accelerators) of modern heterogeneous computing platforms. The proposed research project, named PLATON (Platform-aware LArge-scale Time-Series prOcessiNg), has the potential of great economic and social impact in Europe as multiple scientific and industrial fields are currently in need of the right tools, in order to handle their massive collections of data series.


**Keywords:** data processing, large-scale data-series processing, big data, data series, multi-node processing, multi-threaded processing, accelerators, fault-tolerance, scalability, high performance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Massive QCD-Electroweak Corrections to Higgs Production Through Gluon Fusion at NNLO'.

assistant: **Concept**

So far, the standard model has been an enormous success and even after years of experimental measurements no significant discrepancy between the predictions from computations assuming the standard model and experimental observations has been registered. In order to find an indication of new physics beyond the standard model, we will therefore need to improve the accuracy of both experimental data and theoretical predictions. While experimental predictions are automatically improved with each new measurement, there are various ways in which theoretical predictions can be refined. Most theoretical predictions for the Large Hadron Collider (LHC) are computed as an expansion in the strong coupling constant, as QCD corrections dominate scattering processes at hadron colliders. Due to the high energy in the collision, the mass of some particles is negligible in comparison, and computations are often performed considering all particles to be massless. To improve theoretical predictions, one can compute the scattering amplitudes describing a scattering event at the LHC to higher orders in the coupling constant. This requires us to compute scattering amplitudes with more and more loops as well as more and more external particles and is the standard approach to improve theoretical predictions. Another way to improve theoretical predictions is to relax some of the common approximations, like considering all particles to be massless, that are done in order to make the computations more manageable. In the proposed project, I will analyse the mathematical properties of scattering amplitudes with mixed QCD-electroweak corrections in order to improve current computational methods for such observables. In particular, I will compute corrections to Higgs production through gluon fusion at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'How does surprise influence cognition and behavior?' in the context of a Horizon 2020 call.

assistant: **Objectives**

Humans, like many other species, build models of themselves and their environment, to understand the past and predict the future. These models are constantly evaluated and updated based on new, surprising input. Surprise (i.e., the distance between one’s prior and current beliefs) appears an essential ingredient in various cognitive faculties such as perception, learning, motivation and action and it strongly drives brain activity in both sub-cortical and cortical networks underlying goal-directed behavior. Yet, we currently lack a good understanding of the form and function of surprise signals in the brain.  The overall aim of this research proposal is to elucidate how surprise is computed within sensory circuits and how it influences information seeking behavior. To achieve this, I will: 1) test the theoretical proposition that surprise signals emerge from the discrepancy between prediction signals and input signals that are represented in distinct layers of the neocortex, using ultra-high field neuroimaging in human volunteers; 2) investigate how sensory surprise signals may be communicated to downstream areas to update the brain’s attentional sampling policies; and 3) investigate the relationship between sensory surprise and the explicit drive for information that we call curiosity.This proposal bridges several levels of analysis (from laminar circuit models that calculate sensory surprise to systems neuroscience and computational models of behavior) and several cognitive domains (perception, attention, motivation and curiosity). This multi-scale and multi-method investigation of surprise signals is critical for a more complete and integrated understanding of what may be one of the most important drivers of cognition and behavior.


**Keywords:** prediction, surpris
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of human 3D organoid model of Alzheimer's disease', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Alzheimer’s disease (AD) is the leading cause of dementia, affecting over 50 million people worldwide. Characterized by memory loss, cognitive decline, and the formation of amyloid-β plaques and neurofibrillary tangles, AD presents a significant global health burden. Current AD models, particularly in mice, fail to accurately represent the sporadic form of human AD, limiting the translation of research into effective treatments. Human-induced pluripotent stem cells (hiPSCs) offer a promising alternative for creating in vitro models, but these often lack key features of AD pathology and immune cell interactions.This project aims to develop a 3D organoid model for sporadic AD. We will use nanoparticles as nucleation seeds to facilitate amyloid aggregation from AD patient brain extracts, allowing a more faithful representation of AD pathology. By incorporating microglia into the model, we aim recapitulate human-specific microglial states in AD. By analyzing organoids with and without microglia, we will be able to investigate whether and how microglia contribute to initiation and progression of AD-related pathology, thus providing insights into this so far unanswered question in the field. We will compare all obtained readouts to idiopathic normal pressure hydrocephalus patient brain biopsies, that contain early AD-related pathology, thus verifying that our model is able to recapitulate features of human AD brain. This innovative approach will address the limitations of current models by integrating both neuronal and immune components, offering a more comprehensive platform for studying AD and testing potential therapies. Overall, the project has the potential to advance our understanding of AD mechanisms and contribute to the development of more effective treatments.


**K
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Improvement of numerical models for JTI/GRA Shared Simulation Environment' in the context of a Seventh Framework call.

assistant: **Objectives**

The project iSSE aims at developing a Shared Simulation Environment (SSE) able to simulate the static and dynamic performance of on-board aircraft systems with particular focus on electrical power absorption and thermal energy production. The SSE thereby has to be designed and implemented as a comprehensive solution that provides means to master all essential aspects of the dimensioning for the energy management properties. Given the novelty in the concept of an AEA and the fact that no ready-to-use market solution for a SSE is available, the research need is evident. The final scope is to permit the testing and the validation of the logics used by the Energy Management System (EMS), as well as the simulation of the A/C internal environmental condition.