RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SOIL microbial fuel cells TO (2) POWER precise irrigation systems.' in the context of a Horizon Europe call.

assistant: **Objectives**

Smart agriculture is determined to play a major role to foster water and energy conservation solutions, and innovation technologiesshould be aimed at overcoming current technical, economic, and sustainable barriers. The SOIL2POWER project focuses ondeveloping a breakthrough power sourcing technology based in Microbial Fuel Cells (MFCs), that leverage the natural microbialmetabolism processes using organic matter present at the soil to generate electrical energy. The consortium will build a controlledelectrogenic biofilm formation by immobilization techniques to increase overall biobattery performance, creating a continuous,clean, safe, and maintenance-free energy supply solution. By facing relevant challenges throughout the project, such as bacterialbehavior, startup time conditions or electrode architecture an innovative biological battery of rapid start-up and stable high-powersupply will be conducted to control irrigation valves without maintenance and replacement.Feasibility and validation of separate components have been already conducted through lab studies and will be the starting point toperform a continuous improvement development during the first stages of the project. Afterwards, a prototype will be tested insimulated environment by the end of year 2. If solution is validated with the whole functions up and running, during year 3(2024-2025) a complete deployment of marketing and investment strategies will be performed, alongside operational environmentvalidation to rate real performance based on real feedback from end-users.SOIL2POWER will contribute and ease the transition to develop novel technological solutions by boosting the innovation in cleanenergy solutions industry, strengthening human capital, biotechnological research innovatinos and eventually ena
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Repurposing the CRISPR-associated transposons (CAST) system for gene editing applications' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The rapid advancements in CRISPR-Cas technology have revolutionized gene editing, yet significant challenges persist, particularly the reliance on DNA Damage Response (DDR) pathways and the limitations in integrating large DNA segments. These constraints hinder the application of CRISPR-Cas systems, especially in non-dividing cells and complex genomic modifications. The recently discovered CRISPR-associated transposon (CAST) systems offer a transformative solution, enabling the insertion of large DNA cargos (10–30 kb) into specific genomic locations without inducing double-strand breaks (DSBs), thereby providing a safer and more versatile genome-editing tool. The CASTedit project aims to repurpose CAST systems as next-generation genome editing tools, with a focus on mammalian cells. Specific objectives include the development of engineered CAST systems (Types V-K and I-D) for precise DNA integration, the exploration of novel CAST complexes for RNA-guided transposition, and their validation at the organismal level. Successful implementation of these systems in eukaryotic cells could overcome current CRISPR limitations, paving the way for innovative applications in cell engineering, regenerative medicine, and biotechnology. Under the guidance of Prof. Guillermo Montoya, a leading expert in the structure-function analysis of nucleases, and with his pioneering research in CAST complex assembly at the University of Copenhagen, I will be well-positioned to achieve the goals of this project. I will leverage my expertise in CRISPR-based genome editing, protein expression systems in eukaryotes, and high-throughput mutant screening to optimize CAST systems for precise DNA integration in mammalian cells. The successful execution of CASTedit will establish me as a prominent researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Methods in Neuroimaging', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Body and Brain imaging and its methodological development is a fast growing technique, both quantitatively as well as qualitatively. A long term prospective is that the field needs multidisciplinary expertise of internationally oriented young researchers with a profile of a Neuroimaging scientist, as described in one of the many open job positions (Box 1). The Marie Curie Initial Training Network (MC-ITN) “Methods in Neuroimaging” aims to cover these needs at the European continent. The partners propose a unique multidisciplinary and integrative research and training program with a strong focus on methods. The program aims to specialise early stage researchers and experienced researchers via in-depth integrative training. The training network “Methods in Neuroimaging” will enable them to contribute in a significant, international and multidisciplinary way to the development of new imaging frontiers, i.e. to the development and improvement of image quality, paradigms, analysis, application – and efficiency. Overall the MC-ITN has three aims. First, improved disease understanding and new concepts for early diagnosis and therapeutics evaluation through advance in neuroimaging methods and applications. Second, career development and capacity building for a key technology resource: Expertise in advanced imaging is in short supply and limits expanded use and development of facilities. Third, realising greater value from current imaging investments in research and clinical settings. These aims can be accomplished by the proposed research and training program developed by a multidisciplinary network of core partners. These core partners have an excellent, internationally oriented research and teaching reputation and have available world top laboratory facilities. The core contr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'PRESERT: linking prefrontal cortex, serotonin transporter and social cognition.'.

assistant: **Objectives**

Neuropsychiatric and neurodevelopmental disorders are a heterogeneous group of mental diseases affecting about 1 billion people worldwide. Common alterations are in the cognitive and social domains, having a critical impact on the public health, daily life, and long-term outcomes of affected patients. Unfortunately, efficient pharmacological interventions are still missing. The serotonin transporter (SERT) re-uptakes serotonin after synaptic release and is an important clinical target. SERT is widely expressed in the prefrontal cortex (PFC), an area profoundly engaged in socio-cognitive functions, and can be targeted by inhibitors -drugs acting by blocking the transporter- or by releasers- drugs acting as a substrate of SERT and then reversing its transport direction. The SERT releaser MDMA showed promising results for treating social dysfunctions in post-traumatic stress disorder and autism spectrum disorders and its pro-social effect seems dependent on SERT-reverse transport. Considering the efficacy of the SERT-releaser MDMA in modulating social dysfunctions, together with the need of SERT-reverse functions in mediating MDMA pro-social effects, and the role of the PFC in the regulation of socio-cognitive functions, the aim of PRESERT is to evaluate the impact of SERT on social cognition in mice. To achieve this overarching goal, PRESERT is divided into three specific objectives: i) investigating the impact of the PFC-expressed SERT on social cognition, ii) identifying the origin and connectivity of the underlying SERT-expressing circuits, and iii) evaluating if social cognition can be differentially modulated by the reverse transport (i.e. efflux) or the simple inhibition of SERT. As a direct consequence, PRESERT has the potential to link SERT, its molecular function
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Subsea socket for offshore Platforms based on Tide turbines', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The longer offshore distances of subsea facilities of Oil&Gas rigs are now placed further than decades ago, and inability to power the instrumentations that they require may lead to an economic loss of billions of euros. The power can be supplied through a subsea power and umbilical communication or turbo generators connected to a battery. Yet, these alternatives are very expensive and can be low efficient. The use of renewable energies set near the consumer (off-shore wind, solar or wave energy) seem to be a feasible alternative, but their availability is intermittent and present high capital and operational Costs.  To solve these issues, born from the idea of Current2Current founders –experienced project managers in subsea oilfield for BP Ltd. projects, we have been working on SUBPORT project since 2007. We have developed a compact and simple tidal turbine that can work with flow from any direction, with current speeds < 0.5 m/s, and stable under any water depth and current speed. It can provide up to 20 kWh /day for up to 25 years without the need to change a battery.With SUBPORT project we aim to disrupt into the offshore Oil&Gas market by providing a standalone supply power tidal turbine that will enable our customers to save up to € 15 Mill.  We expect that our technology will allow us to reach a turnover of € 22.8 Mill by selling 45 units and increase our staff 5 times by 2024. Yet, to achieve the commercialisation stage we still need to validate our turbine with potential customers` equipment and get the necessary certifications, and we must plan the dissemination and exploitation activities.Thus, we have decided to continue with SUBPORT for what we need an additional investment of € 3 Mill, that will give us a ROI of 6.8 by 2024. Therefore, we consider essentia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ecological city transport system. demonstration, evaluation and research project of hydrogen fuel cell bus transportation system of the future (ECTOS)' (ECTOS).

assistant: **Innovation**

A consortium of leading European corporations within the area of hydrogen production and fuel distribution, vehicle manufacturing join forces in Reykjavik, Iceland to perform a real scale comparative assessment of the effect of changing the transport energy base from fossil fuel to regenerative produced hydrogen. The ECTOS-project involves research, demonstration and evaluation of hydrogen infrastructure and fuel cell buses. The research will focus on the socio-economic implications of transforming from one fuel to another, transport model research, life-cycle analysis, environmental monitoring and cost-benefit analysis Iceland has been chosen for the project as it is possible to run a hydrogen project in a CO2 free manner, that is there will be no emission of greenhouse gases in the whole energy chain. Results and experience will then be channelled into other similar European projects through various dissemination activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular Editing Towards Non-Classical Carbocations Enables Unprecedented Stereocontrolled SN1 Reactions' (StereoNOne), addressing dissemination and exploitation.

assistant: **Impact**

SN1 reactions represent a possibility for stereocontrolled substitutions on tertiary and quaternary carbons, however the realization of this transformations remains an open issue.  To tackle the challenge of realizing general protocols including a stereochemical information in SN1 reactions, an intriguing viewpoint involve the exploitation of non-classical carbocation (NCCs). NCCs intrinsically have a stereochemically robust nature since one face is shielded by their carbon skeleton, allowing an easier control of stereochemistry. In the last years, Mareks group have been interested in the chemistry of non-classical carbocations resulting from the dissociation of cyclopropyl carbinols. The group has faced and rationalized this challenge, and stereospecific SN1 at quaternary stereocenters of cyclopropanes has emerged as a powerful tool for the construction of stereodefined acyclic structures. A complete inversion of configuration was observed in the presence of different nucleophiles, filling a methodological gap in organic chemistry. To overcome the current state of the art, the establishment of a general approach that would control stereochemistry for SN1-type reactions extending the generality of the already impressive results obtained by the host group is meticulously planned. The aim of this proposal is to broaden the chemistry of stereocontrolled SN1 using 4-membered rings for the creation of acyclic stereo- and enantiodefined systems. Furthermore, in the following sections a detailed description about the impact that this action will have on the growth of the hosting group, the synthetic chemistry community and my career is highlighted.


**Keywords:** Molecular Editing, Skeletal Rearrangements, Stereoselective Transformations,  SN1 Reactions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'ADvanced Reactor Initiative And Network Arrangement'.

assistant: **Objectives**

The coordinating action ADRIANA (ADvanced Reactor Initiative And Network Arrangement) is proposed to setting up the network dedicated to the construction and operation of research infrastructures in support of developments for the European Industrial Initiative for sustainable nuclear fission. The project as the base for the current long-term taking place coordination activities of Euroatom under financial support of the European Commission for construction of research infrastructure in the frame of Structural funds of the European Union suggests the program of utilization of built-up facilities for the given purpose. The project for this purpose defines in detail the new needed research infrastructures, defines and provides legal and financial structures for major refurbishment or upgrading of existing facilities, the construction of new ones and considers the trans-national access to these experimental facilities. Assurance of long-term reliable and competitive energy resources has been an indispensable request for sustainable development of EU communities and their competition’s positions in the frame of the worldwide economic development and political influence in the process of global governance. The Project solves the above given objectives for reactor systems and connecting technologies: · Sodium Fast Reactor (SFR) · Lead Fast Reactor (LFR) · Gas Fast Reactor (GFR, including very high temperature technologies) · Instrumentation, diagnostics and experimental devices · Irradiation facilities and hot laboratories · Zero power reactors · Road map of research infrastructures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PV FACADE INTEGRATION IN LEHRTER STATION BERLIN' in the context of a Fourth Framework call.

assistant: **Objectives**

The photovoltaic generator with a total area of 3311 m² shall be integrated in the area-covering structure flush with the adjacent single glazing of the glass roofing of the new Lehrter Bahnof railway station in Berlin. The station hall represents itself a east-west oriented and slightly bent barrel vault roof. The PV modules will be integrated tilted from 7° to 19° on the south side of the east/west oriented glass roof hall.By using high efficiency mono-crystalline cells the nominal power of the PV generator will achieve about 325 kWp. Being integrated in the mains, the complete installation shall generate electric power amounting to approximately 274000 kWh. The photovoltaic installation shall be run in parallel operation with the mains. The electric power generated will be supplied to the low voltage mains of BEWAG. Analogously to the EC and ISPRA requirements, the photovoltaic installation will be monitored for a period of two years. Analytic data acquisition will be performed in accordance with the Guidelines for assessment of photovoltaic installations". The architectural and town planning importance of this project is underlined by the direct neighbourhood to the governmental buildings and the significance of the most important railway station of the Berlin capital in the future. The representative and advertising functions of Lehrter Bahnhof for the Deutsche Bahn AG go along with generation of regenerative power from sunlight.- The photovoltaic generator consists of 1440 modules and covers a total area of approximately 3311 m². The nominal output of the generator with its 133200 PV cells is about 325 kWp.- The PV modules are supplied by Pilkington Solar International. The modules are incorporated into the glass structure as part of a triple layer system.- All PV
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Injectable anisotropic microgel-in-hydrogel matrices for spinal cord repair' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

This project will engineer an injectable biomaterial that forms an anisotropic microheterogeneous structure in vivo. Injectable hydrogels enable a minimal invasive in situ generation of matrices for the regeneration of tissues and organs, but currently lack structural organization and unidirectional orientation. The anisotropic, injectable hydrogels to be developed will mimic local extracellular matrix architectures that cells encounter in complex tissues (e.g. nerves, muscles). This project aims for the development of a biomimetic scaffold for spinal cord regeneration.To realize such a major breakthrough, my group will focus on three research objectives. i) Poly(ethylene glycol) microgel-in-hydrogel matrices will be fabricated with the ability to create macroscopic order due to microgel shape anisotropy and magnetic alignment. Barrel-like microgels will be prepared using an in-mold polymerization technique. Their ability to self-assemble will be investigated in function of their dimensions, aspect ratio, crosslinking density, and volume fraction. Superparamagnetic nanoparticles will be included into the microgels to enable unidirectional orientation by means of a magnetic field. Subsequently, the oriented microgels will be interlocked within a master hydrogel. ii) The microgel-in-hydrogel matrices will be equipped with (bio)functional properties for spinal cord regeneration, i.e., to control and optimize mechanical anisotropy and biological signaling by in vitro cell growth experiments. iii) Selected hydrogel composites will be injected after rat spinal cord injury and directional tissue growth and animal functional behavior will be analyzed. Succesful fabrication of the proposed microgel-in-hydrogel matrix will provide a new type of biomaterial, which enables investig