RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeting Circadian Clock Dysfunction in Alzheimer’s Disease' (TClock4AD), addressing dissemination and exploitation.

assistant: **Impact**

Recent Nobel Prize-winning discoveries on circadian clock (CC) have laid the foundation for ground-breaking approaches to treat many diseases, including Alzheimer’s disease (AD). AD is a current public health priority. Amplifying the demographic burden of the rising numbers of patients is the low success rate of AD therapies. Given that CC genes regulating memory, sleep, and neurodegeneration have altered expression profiles in AD, CC has recently emerged as a viable therapeutic target for new effective drugs. However, how to develop them remains a fundamental challenge. The “Targeting Circadian Clock Dysfunction in Alzheimer’s Disease” Doctoral Network (TClock4AD) is proposed to create a new generation of researchers able to face such challenge by harnessing neurobiology, medicinal chemistry, pharmaceutical nanotechnology, neuroimmunology, big data, bioinformatics, and entrepreneurship. TClock4AD will exploit unique expertise and advanced technologies at 10 leading universities, 3 research centers, a hospital, 10 non-academic institutions including SMEs, a large pharma company, a Health industry association, and a patient organization across EU, UK, Israel, USA and China. TClock4AD will deliver double degrees to 15 doctoral candidates, with triple-i knowledge/skills, broad vision and a business-oriented mindset. Their research activities will be structured around 5 scientific themes to: (1) develop novel artificial intelligence-, proteolysis targeting chimeras- and multitarget-based strategies for new CC drug candidates (2) develop novel drug delivery nanotechnologies, which take into consideration CC (3) investigate innovative in vitro (stem-cells, 3D cultures) & in vivo (Drosophila), as well as organ-on-chip techniques, for preclinical validation of CC drugs (4) get
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Scientific Excellence in Animal Reproductive Medicine and Embryo Technology' in the context of a Horizon 2020 call.

assistant: **Objectives**

The aim of the SEARMET project is to improve the scientific knowledge and innovation capacity of the Estonian University of Life Sciences (EMU) in the linked fields of animal reproductive medicine and embryo technology. This will be done by strengthening collaboration with two high-ranking foreign academic institutions: Sheffield University (USFD), a leading university in the field of reproductive physiology and in the gametes and embryo maternal interaction and Copenhagen University (UCPH), which is a model of excellence in the in vitro production (IVP) of bovine embryos and in induced pluripotent stem cells (iPSC) research. Furthermore, in order to achieve scientific excellence in animal reproductive medicine, EMU must also work to make stronger linkages with human reproductive research. For this reason, EMU’s long-time collaborator within Estonia, the University of Tartu (UTARTU) will participate as a 4th partner. Due to their high level of competence in making this link, both USFD and UCPH will serve as mentors in this process as well. In addition to building bridges to human reproductive research, EMU will increase its research excellence by improving staff expertise, expanding its network of potential scientific partners and building the overall capacity of the organization so that it can become a leader in the field. By doing so, EMU will achieve a greater impact in both the scientific community and in society by reaching out to key stakeholders such as industrial actors so as to exploit the results of research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovative tank design and groundbreaking infrastructure model to enhance the availability of renewable energy by collecting, storing and transporting hydrogen, biomethane, nitrogen and LNG' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The depleting reserves and the increasingly high cost of extraction are making oil difficult to access. The development andpromotion of abundant and clean alternatives such as liquid hydrogen, liquid biomethane, nitrogen (all renewable fuels) andLNG is becoming a necessity. These gaseous fuels are among the serious options to be considered. Hydrogen, for example,can be produced anywhere where there is water and a source of electricity. And hydrogen-fueled vehicles emit nogreenhouse gases or other pollutants. During combustion, hydrogen produces only water vapour.However, these fuels have significant infrastructure and transport limitations. Hydrogen is currently expensive also becauseis difficult to handle and store. The same applies to fuels like LNG.The current method of transporting LNG and other gas-based fuels like hydrogen, biomethane and nitrogen, is the cryogenictanker. Specialised driver/operator training, and expensive equipment is required to handle these tanker—trailers and assuch, there is often limited infrastructure for them outside states with large petrochemical industries. This limited transportinfrastructure has, in turn, led to limited support infrastructure.GGLS has developed the GBG™, lightweight composite tanks for collecting, transporting and storing cryogenic materials,specifically gaseous fuels. These patented tanks can be used as an integral part of a system to maintain a continuouscryogenic gas supply or as on board fuel tanks for use in road vehicles, particularly heavy trucks, coaches, buses and vansor for rail, marine and aircraft applications.GBG™ innovative tanks are capable of revolutionising the collection, distribution and storage at the point of use ofrenewable fuels in both cryogenic and gaseous forms. Indeed, rather than transferri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Attosecond X-ray spectroscopy of liquids' in the context of a Horizon 2020 call.

assistant: **Objectives**

Charge and energy transfer are the key steps underlying most chemical reactions and biological transformations. The purely electronic dynamics that control such processes take place on attosecond time scales. A complete understanding of these dynamics on the electronic level therefore calls for new experimental methods with attosecond resolution that are applicable to aqueous environments. We propose to combine the element sensitivity of X-ray spectroscopy with attosecond temporal resolution and ultrathin liquid microjets to study electronic dynamics of relevance to chemical, biological and photovoltaic processes. We will build on our recent achievements in demonstrating femtosecond time-resolved measurements in the water, attosecond pho-toelectron spectroscopy on a liquid microjet and measuring and controlling attosecond charge migration in isolated molecules. We will first concentrate on liquid water to study its electronic dynamics following outer-valence ionization, the formation pathway of the solvated electron and the time scales and intermolecular Coulombic decay following inner-valence or core-level ionization. Second, we will turn to solvated species and measure electronic dynamics and charge migration in solvated molecules, transition-metal complexes and pho-toexcited nanoparticles. These goals will be achieved by developing several innovative experimental tech-niques. We will develop a source of isolated attosecond pulses covering the water window (285-538 eV) and combine it with a flat liquid microjet to realize attosecond transient absorption in liquids. We will complement these measurements with attosecond X-ray emission spectroscopy, Auger spectroscopy and a novel hetero-dyne-detected variant of resonant inelastic Raman scattering, exploiting the large ba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'MERGING ATOMISTIC AND CONTINUUM ANALYSIS OF NANOMETER LENGTH-SCALE METAL-OXIDE SYSTEMS FOR ENERGY AND CATALYSIS APPLICATIONS' in the context of a Seventh Framework call.

assistant: **Objectives**

The stability of thin films in contact with different materials is a critical issue for a wide range of modern devices, including high-k films in the microelectronics industry, metal electrodes for fuel cells, and nanometer sized particles on oxides for catalysis. Some groups are working on thermodynamic analysis of thin film stability, who correlate relative interface energies with dopant adsorption. While this provides important thermodynamic parameters which can be used to evaluate the stability of thin films, information on the detailed atomistic structure and chemistry of the same interfaces needs to be correlated with the thermodynamic approach. Other groups use advanced characterization approaches to determine local atomistic structure and chemistry, and theoretical groups explore interface structure and energy through computational methods. It is the goal of this project to bridge between these working groups.   This project will establish an environment to promote communication and collaboration between groups using thermodynamic approaches with groups studying the atomistic structure of interfaces, since bridging this particular scientific gap has the potential to result in new design criteria for advanced material systems. The project is based on a core group of European, and International partners, who have realized that such a form of communication is critical to advancing the field of interface science and interface based technology. The partners will establish structured programs for discussion via focused public workshops and summer schools, and via scientific exchange. While the core group of partners is academic, European industry will be involved in the structured discussions.   The expected impact from this four-year project is methods to correlate b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Ultra-high resolution imaging of GluR1 trafficking in neuronal spines'.

assistant: **Innovation**

The spatial and temporal regulation in the composition of the postsynaptic membrane of synapses participates to the different forms of synaptic plasticity that trigger the cellular processes of memory formation, consolidation, and retrieval. Neurotransmitter receptors move rapidly in and out of synapses by lateral diffusion. This mobility is crucial to control the number of receptors present at a given synapse. AMPA subtype glutamate receptors mediate most excitatory transmission in the brain. Thus, the equilibrium between the synaptic and extrasynaptic AMPA receptor number is crucial in controlling basal transmission and synaptic plasticity. This balance is regulated by the subunit composition of these receptors and by interacting intracellular scaffold proteins. The GluR1 subunit of AMPA receptors plays a crucial role in activity dependent synaptic plasticity. However, how trafficking of GluR1 in and out synapse is controlled remains unknown. The major aim of this project will thus be to determine the relative distribution and trafficking properties of GluR1 at unprecedented spatial and temporal resolution using a variety of ultra-high resolution fluorescence imaging approaches. Emphasis will be laid on the molecular basis for the activity dependant changes in GluR1 localization and mobility. We will study in particular the role of calcium induced phosphorylation events and GluR1-SAP97 interaction in controlling GluR1 fluxes in and out of synapses. This will provide a unique insight into the fundamental aspects of synaptic plasticity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Photovoltaic materials from novel self-assembling nanostructured liquid crystals' (LC-ENERGY) targeting Sixth Framework.

assistant: **Abstract**

This proposal aims to improve the current generation of organic photovoltaic materials by controlling the molecular morphology, a key parameter in the development of organic solar cells. Self-organisation is activated by a newly discovered nanophase segregation process between rod- and disc-shaped molecules. Moreover, the overall liquid crystalline properties of the system allow macroscopic alignment, giving rise to an optimised geometry at all length scales.The proposed project covers the entire chain of knowledge: the design and preparation of the nanophase segregating materials, a detailed investigation of the electro-optical properties, and the analysis of the photovoltaic behaviour. This approach is an attractive method for studying functional materials and allows a direct link from fundamental research to technology-based industries.Apart from developing new concepts in light harvesting and sustainable energies, the proposal envisages advances in the field of nanosciences, particularly in the control of self-organisation and nanostructure formation. Basic understanding of the parameters for self-organisation will be generated, which contributes to the process of conceptualisation, required to support future technological breakthroughs in the field of nanosciences.In the proposal, a close collaboration between the scientist from top-level institutes like MIT, Boston and the University of Nijmegen is realised. The institutes provide a state-of-the-art training opportunity for the applicant. Knowledge and experience built-up during the project can easily disseminate into national and European projects concerning photovoltaic technologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Intelligent recognition materials for extraction and detection' (IRMED).

assistant: **Concept**

This project will focus on the development and optimisation of intelligent recognition materials for applications in extraction and detection, focusing on the molecular imprinting approach. Three key scientific aims have been identified: (i) development and optimization of imprinted polymers; (ii) MIPs and applications to the market (iii) new concepts and innovative thinking in intelligent recognition materials. This partnership brings together three teams from France and the United Kingdom. The scientific interests of these groups have a common denominator in the application of molecular imprinting for the preparation of new intelligent materials and the use of these materials in synthesis, catalysis and assay devices while the scientific background of the groups is divergent ranging from bioengineering and nanobiotechnology to synthetic chemistry and polymer chemistry all the way to product oriented research and technology R&D. The transfer of knowledge program has been devised taking into account the three main objectives of this partnership, that are (T1) scientific ToK; (T2) professional development; (T3) long term collaborations. The partnership has identified five key actions along which the program will develop, and these are i) secondment of researchers, ii) recruitment of new researchers, iii) partnerships events, iv) return home plan, v) interactions between principal investigators. The field of molecular imprinting has now reached an important stage where further technological advance will require closer interactions of academia and industry. Researchers with broad competences in chemistry, chemical technology as well as product development are needed to bring this promising and truly European technique into its new stage of application and commercialisation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Nuclear singlet state in diamond for overcoming the standard quantum limit in gravitational wave detectors' (SingletSQL).

assistant: **Concept**

The sensitivity of the next-generation gravitational-wave detectors (GWD) are critically limited by the quantum fluctuations of light. The major sources of such noises are shot noise and optomechanical back action noise (BAN). The improvement of sensitivity can be achieved by back-action evading (BAE) measurements, which allows overcoming the standard quantum limit. By trading off between shot and BAN, recently a promising scheme has been proposed which involves another auxiliary system, consisting of an atomic spin ensemble with negative effective mass that can suppress both the noises. The measurement is performed by two entangled beams of light probing the GWD and the spin ensemble. However, the approach exhibits three major implementational issues to focus on, which I have discovered by recent calculations. Firstly, I study how the sensitivity of the GWD is dependent and what the constraints introduced by the entanglement measures between subsystems. Secondly, I come with a novel approach for the BAE by using a nuclear singlet state of carbon in diamond which works at very low NMR frequencies and bandwidth aiming to avoid the discrepancies of the match between the frequencies and linewidths of the spin and the mechanical oscillators. In this aspect, I propose using a novel type readout of electron spin of NV centers, used as a non-perturbing ancilla of the nuclear spin-singlet. Finally, based on the parameters obtained from ongoing E-Test project, where a low thermal noise mechanical oscillator is being built up, I will theoretically investigate if the nuclear singlet state can match the frequency and bandwidth of rational parameters of the oscillator and whether it can be implemented for the BAE measurement. I will study the role played by the input squeezing param
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Molecular and cellular interactions between the plant protective bacterium Bacillus subtilus 49b and the plant pathogen Fusarium oxysporum causing tomato root and foot rot' under Sixth Framework.

assistant: **Concept**

Fungal attack leads to major agricultural crop losses. Use of chemical pesticides to suppress fungal pathogens forms a threat to the environment and human health since some of these pesticides are very persistent and hazardous. Development of environmental friendly disease control strategies, such as biological control based on the use of protective microorganims, is highly required.The efficacy of biocontrol agents (when applied as an inoculant) is not always consistent. Fundamental knowledge on the inter actions between the fungus and the biocontrol bacterium is required to understand how the biocontrol bacterium functions at the cellular and molecular level, which forms the basis for the biocontrol effect, and which will contribute to an improved inoculum application.This study will focus on the biocontrol bacterium Bacillus subtilus strain 49b, which is able to protect tomato roots against the attack of the phytopathogenic fungus Fusarium oxysporum. Bacillus bacteria are very suited for inoculum production since they form heat and drought resistant spores. One of the mechanism through which biocontrol of strain 49b might function is its production of anti fungal metabolites (antibiotics), which after a first analysis seem to be of an unknown class.The project aims at an integrative approach of biochemical, genetic and microscopic analyses to elucidate the biocontrol mechanism(s) of B. subtilus strain b49. State of the art equipment and methods, including confocal laser scanning microscopy and microarray analysis, will be applied to study the interaction of B. subtilus with the target fungus on the tomato root.The project will result in the identification of the anti fungal metabolites, elucidate their relevance for biocontrol, identify genes that are relevant for bi