RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Signals for accommodative responses in humans' (SACCO).

assistant: **Innovation**

Long-term objectives are to identify optical signals that control accommodation and emmetropization of the eye, and to identify the mechanisms that mediate the optical signals. A primary goal is to determine whether accommodation responds to the wavefront characteristics of light [defocus and higher-order aberrations (HOAs)], without feedback from change in defocus astigmatism or HOAs. Accommodation, pupillary responses and aberrations will be monitored by an imaging simulator that incorporates Hartmann-Shack wavefront sensing, adaptive optics and Hirschberg x-y eye tracking. Adaptive optics and Badal optics will compensate for the refractive error of the eye, alter or remove HOAs, and remove feedback from changes in accommodation and/or HOAs. Accommodation will be driven by defocus with normal HOAs present or removed. To determine whether accommodation responds to wavefront aberration per se, or simply to the shape or skewing of blur, aberrations will be removed while simulation of defocus targets are imaged on the retina, with and without the effects of HOAs on the blur. Standard model that accommodation operates as a closed-loop negative feedback system to maximize the contrast retinal image, will be tested by using adaptive optics to remove defocus, astigmatism and HOAs and by establishing a closed feedback loop between accommodation and target contrast. An alternative hypothesis that accommodation responds to wavefront defocus rather than blur of the retinal image, will be tested by driving accommodation with defocus without feedback from blur, in the absence of HOAs. A final experiment will determine whether the pupil changes independently of lenticular accommodation to provide better acuity in the presence of spherical aberration. Better understanding of the opti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Elites, networks, and power in modern urban China (1830-1949).'.

assistant: **Objectives**

This project proposes a step-change in the study of modern China reliant upon scalable data-rich history. It will deliver precise historical information at an unprecedented scale from heretofore untapped sources - as well as reshaping the analysis of existing sources - to create a new dimension in the study of the transformation of elites in modern China. It will deploy an array of cutting-edge digital methods — including data mining, sampling, and analysis within an integrated virtual research environment. To establish the validity of this approach, the project focuses on the three urban areas (Shanghai, Beijing/Tianjin, Canton/Hong Kong) that had the most profound impact on the course of modern Chinese history. Starting from the mid-19th century, the narrow elite of Confucian-trained scholar-officials that had ruled the country for a millenium was finally swept away. Power and social prestige shifted to socially more diversified groups of Chinese and foreigners who operated within interlocked transnational networks. The project will challenge the China-centered and group-based approach dominant in the historical literature of the past two decades. The project envisions elites in urban China as actors whose status, position, and practices were shaped by the power configurations that developed over time and whose actions through institutions and informal/formal networks in turn were a determining factor in redrawing social and political boundaries. The project will place the emphasis on the networks through which information, capital, and individuals circulated. It will investigate the transnationalization of elites as a process that overstepped the limits of institutions and nation states. The key issue that the project will address is breaking through existing limits
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'HyCO2 - Upscaling of Metalhydride compressor for flexible application ranges', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

HyCO² aims to revolutionize hydrogen compression technology by upscaling and demonstrating an innovative metal hydride (MH) compressor tailored for diverse application ranges across mobility, distribution, and industrial sectors. The project addresses the critical need for efficient, cost-effective, silent and environmentally sustainable compression solutions in a hydrogen-based economy.The central objective is the development of a modular MH compressor package capable of flexibly addressing varied pressure requirements, from 30 bar for industrial applications, to 300 bar for distribution, and up to 900 bar for mobility applications. This versatility will be validated with a full-scale prototype demonstrating high flow performance (30 kg H2 in 12 minutes at 900 bar) under real-world conditions at a dedicated research facility. To ensure environmental compatibility and long-term sustainability, HyCO² aims to select and integrate a non-toxic, highly recyclable, and abundantly available metal hydride alloy offering superior performance and durability. The project will further explore cost reduction strategies through effective waste heat utilisation and advanced thermal management techniques by means of a sophisticated simulation toolchain, significantly lowering the operational costs of hydrogen compression in targeted applications.In parallel, an innovative hydrogen-based heat box will be developed to enhance the compressor’s flexibility and operational efficiency across various environments and configurations.By tackling key challenges in hydrogen compression, HyCO² directly supports the objectives of the Clean Hydrogen JU’s Annual Work Programme, particularly the advancement of robust, scalable, and sustainable hydrogen technologies. The outcomes of HyCO² will accelera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The role of phylogenetic relatedness in invasion success: A multidisciplinary study of marine biological invasions' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The recent expansion in the field of molecular biology, and its implementation within other fields, has inevitably changed our perception of many biological sciences. As a result, new fields including community genetics and community phylogeny have emerged, which have greatly influenced the study of biological invasions. Our understanding of biological invasions has benefited from the use of community phylogenetic approaches; however, these advances have been made through the study of terrestrial ecosystems, while the study of marine environments remains largely unexplored. Marine ecosystems worldwide are being dramatically altered due to the vast arrival of non indigenous species (NIS). MarInvasPhylogen will employ an innovative multidisciplinary approach to obtain a holistic and mechanistic understanding of the role of phylogenetic relatedness in the invasion process. The following research questions will be addressed: Is invasion success in marine systems predictable based on phylogenetic relatedness? Are particularly problematic invasive species more phylogenetically distinct from natives than those that pose little threat? This project will focus on invasive marine invertebrates, as they are the NIS that most affect native communities, human economies and global biodiversity along coastal areas worldwide. During the outgoing phase, extensive training on phylogenetic tools will be undertaken and research on community phylogenetics, molecular phylogeny and community ecology implemented. During the return phase, a morphological phylogenetic study will be developed. This project will ascertain the congruence among the results found in the study of community phylogenetics, molecular and morphological phylogenies, and community ecology. MarInvasPhylogen will therefore pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Quercus Ilex proteomic studies on the germination and early seedling growth under drought stress' (QUIPROD).

assistant: **Innovation**

BACKGROUND: Proteomics is a high-throughput approach that could provide comprehensive understanding of complex developmental processes. Holm oak (Quercus ilex L.) is a dominant tree in Mediterranean natural communities. Oak seeds are recalcitrant. Seed proteome and germination under stress are studied predominantly in cereals and model plants, but there is very limited information on forest species.OBJECTIVES: This project aims to study germination and early seedling growth of Holm oak at the proteome level, focusing particularly on how these processes are affected by drought. Emphasis will be placed on phosphorylation and ubiquitination as major posttranslational modifications (PTM). Proteome analysis will be complemented with data at the metabolite and transcript levels and with cytochemical observations.METHODOLOGY: Holistic and targeted approaches will be combined.Holistic approach – by using gel and gel-free, including label free quantitation approaches coupled to MS, changes in the protein and PTM profiles associated with the germination and stress responses will be analyzed. PTM will be detected by specific staining or Western blot. Appropriate statistical analysis, algorithms, databases and repositories will be used.Targeted approach – the oxidative status of the tissues will be monitored and more detailed analysis of some proteins of interest will be performed at the transcript level. Analyses at the metabolite level will include carbohydrates (ethanol extraction, GC-MS), aminoacid derivates (ethanol extraction, HPLC quantification), some secondary metabolites (GC or HPLC). Histochemical staining of carbohydrates, phenolic compounds, and H2O2 will also be performed.EXPECTED RESULTS: To gain deeper knowledge of the response to drought in a recalcitrant seed- pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Feasibility study of a bionic agitator – a prototype of this agitator has shown great potential for energy reduction of agitator technology.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

A prototype of a newly developed agitator has shown great potential for energy reduction in agitator technology. The developed agitator was inspired by the way ducks move their feet in the water – a very energy-efficient way. Consequently we call the new agitator a bionic agitator. Now we want to validate the findings from the test of the prototype in a beta-phase test.The idea to question the current agitator technology arose, while analysing the reasons for small biogas plants (<75kW, operating on organic waste) not being profitable. Martin Falger, the inventor of the bionic agitator and major shareholder of the wusoa GmbH, focused on the fact, that the highest fraction of the primary energy consumption of a biogas plant is needed for the agitator used in the same plant. The prototype of the bionic agitator has shown the potential to reduce this energy consumption by 60 per cent or more. Thus more of the produced energy in the biogas plant can be fed into the grid. As a result of this increase in the effective output it becomes more attractive to generate energy from organic waste – which means a 100% carbon neutral way of energy production and a great contribution to the EU goals of reducing emissions by 80% in 2050.The proposed feasibility study includes a field test where the bionic agitator is installed in five existing biogas plants. One additional bionic agitator will be installed in the biogas plant of the University of Hohenheim (Stuttgart, Germany) to test it against a conventional agitator. The aim of the feasibility study is to obtain reliable data on the energy reduction, the material used and to get a solid feedback from potential customers.We estimate that the European market for agitators in the biogas industry is approx. worth 2.7 billion euro. However
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Mining for new antimicrobials in ant associated actinomycetes'.

assistant: **Objectives**

The proposed research is multidisciplinary and involves using state-of-the-art technologies (combined genomic and metabolomic approaches) to discover new antifungal compounds from an untapped environmental niche that the groups of Goss and Hutchings are currently mining. Novel methodologies developed by Dr Gao within Professor Lixin Zhang’s group will be utilized to rapidly mine the ant associated microbes for novel bioactive natural products and to engineer enhanced levels of antibiotic and antifungal production. Synergic interactions of the antibiotics will be explored using high through put assays developed by Dr Gao and Professor Zhang
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Achieving Complex Collaborative Missions via Decentralized Control and Coordination of Interacting Robots' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Imagine a scenario where multiple robots have been deployed to provide services such as object handling/transportation, or pickup and delivery operations. In such a context, different robots with varying capabilities must be coordinated in order to achieve various multi-tasking procedures. Thus, the effective supervision and coordination of the overall heterogeneous system mandates a decentralized framework that integrates high-level task-planning, low-level motion control and robust, real-time sensing of the robots’ dynamic environment. Current practice is at a great deal based on offline, centralized planning and related tasks are usually fulfilled in a predefined manner: this does not utilize the capabilities of the system to operate efficiently in a dynamic environment. In most cases, sudden changes in the environment, the type of tasks, and the need for coordination, would cause the system to halt, ask for human intervention and restart. Despite the fact that public facilities are in some degree prestructured, the need for a framework for decentralized, real-time, automated task (re)-planning is evident in a twofold manner: (i) it will pave the way to an improved use of resources and a faster accomplishment of tasks inside public facilities and workspaces with high social activity; (ii) it will make an important contribution towards the vision of more flexible multirobot applications in both professional or domestic environments, also in view of the “Industry 4.0” vision and the general need to deploy such systems in everyday life scenarios. Within Co4Robots our goal is to build a systematic methodology to accomplish complex specifications given to a team of potentially heterogeneous robots; control schemes appropriate for the mobility and manipulation capabilities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An Open Source Environment to construct Information Services for Children' (PuppyIR) targeting Seventh Framework.

assistant: **Abstract**

As adults we are keen to help children maximize their full potential. Developing children's abilities to find and understand information is key their development as young adults. The Internet offers children exciting new ways to meet people, learn about different cultures and develop their creative potential. However, children's ability to use the Internet is severely hampered by the lack of appropriate search tools. Most Information Retrieval (IR) systems are designed for adults: they return information that is unsuitable for children, present information in lists that children find difficult to manage and make it difficult for children to ask for information. Worse, almost all Internet search engines confront children with pornography and other inappropriate material. PuppyIR will help children search the Internet safely and successfully by the design of an Open-Source platform of child-friendly information services. PuppyIR will provide a suite of components that can be used by system designers to tailor IR systems for their specific needs. PuppyIR will develop new interaction paradigms that allow children to express their information needs simply and have results presented in an intuitive way. It will develop Information Services that can summarise content for children, moderate information for children, help children safely build social networks and intelligently aggregate for presentation to children.  PuppyIR will also contribute to the evaluation of children's IR systems by the development of child-centered evaluation methods. PuppyIR will be a multi-layered architecture: system designers can choose from several interaction paradigms and information services to construct their own system. As PuppyIR is Open-Source it will be extensible for new information source
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Biochemical Characterization of the Apt1/Cdc50 Complex' (BiCoACC).

assistant: **Concept**

Cryptococcus neoformans is an opportunist fungal pathogen lethal for patient with AIDS. Treatment options are limited and there is an urgent need for the discovery of anti-fungal drugs. The membrane proteins Apt1 and Cdc50 from C. neoformans were identified as potential drug targets since it is involved in antifungal resistance and pathogen’s virulence. Apt1 belongs to the P4-type ATPase family and together with Cdc50 proteins they are involved in the maintenance of phospholipid asymmetry in biological membranes. In this project I plan to biochemically characterize Apt1/Cdc50 from C. neoformans, to identify inhibitors and functionally impaired mutants of this complex. These in vitro findings will be translated in vivo in C. neoformans cultures. I plan to join the Laboratoire des Protéines et des Systèmes Membranaires (LPSM) at the CEA Paris-Saclay, a world-leading lab on P4-type ATPases, where I will set up protocols for the expression and purification of the Apt1/Cdc50 complex expressed in Saccharomyces cerevisiae. Furthermore, thanks to my expertise in membrane protein reconstitution in liposomes and functional analysis, I will set up an assay to monitor in vitro phospholipid transport, an expertise still lacking at the LPSM. Using purified functional Apt1/Cdc50 complex we will screen a chemical library to identify inhibitors of this complex. In parallel a structure-function study of the complex using directed mutagenesis will be conducted. Finally, in vitro findings will be translated in vivo thanks to a collaboration with Pr Kronstad (University of British Columbia), a world expert on C. neoformans pathophysiology, where C. neoformans cultures are available. This multidisciplinary project will benefit from the expertise of the host institution on P4-ATPases, my know