RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'MOBILE USER GENERATED GEO SERVICES' (MUGGES) targeting Seventh Framework.

assistant: **Abstract**

The MUGGES project proposes the usage of LBS GNSS technology as a driver of the Mobile User-Generated social service paradigm, which represents a very clear current trend of business innovation. The mobile terminal will evolve to become also a server. When put into exploitation directly by using the mobile device, a mobile user will provide constantly updated information, relevant to other users instantaneous interests and current context, in particular with location tagging. The project will develop the basic components and market-ready MUGGES applications to permit the provision, remote discovery and access of information from a mobile device to a mobile device, by means of the “location” attribute of context as key service and content characterization. A full evaluation of the components and business models brought forward by MUGGES, i.e. social mobile location-aware user-generated services, will be carried out through a trial. This trial will remain open after the project ends, providing a long-term behavioural assessment on the adoption of the GNSS-based technology for the proposed mobile exploitation scenarios, where location clearly adds value. The subsequent analysis of the data will provide valuable information for the widespread deployment of this innovative type of mobile GNSS-based solutions in Europe in further steps. The project addresses the obstacle identified in the topic GALILEO-2007-1.1-0.2, by exploiting the full potential of GNSS for the deployment of a new (on the move) type of innovative, mass market user-generated services. MUGGES will definitely contribute to the GALILEO objectives by demonstrating that there is a great mass market potential for LBS in Europe and that the technology is mature enough to deliver real benefits to users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Safer gene repair and targeting based on the monomeric meganuclease I-DmoI by design of homologous-recombination-inducing nickase activity' (DMONICKASEDESIGN) under Seventh Framework.

assistant: **Objectives**

An important aspect of cancer therapy is the specificity of the treatment. Significant progress has been made in drug design. However, gene therapy by direct targeting of oncogenes has not yet met equal success. Among the most valuable tools are meganucleases, also known as homing endonucleases (HE). These enzymes recognize and cleave long (around 20bp) DNA sequences and have been shown to induce gene repair in vivo efficiently. The mechanism involves induction of homologous recombination (HR) by creating a double strand break (DSB) of DNA. HEs also have the significant advantage of being amenable to redesign for new target sequences. Applications have been demonstrated, for example, in the treatment of xeroderma pigmentosum, a condition associated with skin carcinomas. Unfortunately, inducing HR by DSB tends to produce genetic instabilities. A safer alternative would be to use single-strand-cleaving enzymes (nickases). However, this must be done retaining sequence specificity, a property unavailable in natural enzymes. Consequently, engineering is necessary. A promising candidate for redesign is the monomeric HE I-DmoI, but details of the mechanism, namely the role of metals in the active site and the precise timing of strand cleavage, must still be unraveled. X-ray and mutagenesis experiments performed at CNIO provided significant, although incomplete, evidence on those crucial aspects. Experimentally-supported theory and computational modeling can help clarify remaining incognitas, such as the strand preference of the enzyme. We will use state-of-the-art computational methods (ab-initio molecular dynamics, hybrid Quantum Mechanics/Molecular Mechanics and molecular modeling), to gain insight into aspects of the mechanism not seen in experiments, including the timing o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Towards a “Topography” of Tolerance and Equal Respect. A comparative study of policies for the distribution of public spaces in culturally diverse societies' to be submitted under Seventh Framework.

assistant: **Abstract**

Tolerance has been increasingly invoked as the inspiring ideal of a number of social policies in European democracies. Appeals to tolerance have animated especially the political debates on those policies addressed to accommodate minorities’ requests. Among such requests those for the allocation of public spaces have recently acquired pride of place in the political agendas of many European and extra-European countries (e.g. the allocation of space for Roma sites; Muslims’ requests to build places of worship and housing policies for migrants). Despite such a generalized political and societal relevance of the notion of tolerance, some problems may occur when policies inspired by it are implemented. In particular, the implementation of tolerance-inspired spatial policies may result in the marginalisation of differences and thus risk undermining social cohesion. What conception of tolerance may be invoked to limit such a risk? To answer this question, we shall test the hypothesis that grounding tolerance on equal respect for persons may contribute to the development of spatial policies capable of resolving the tensions between tolerance and social cohesion in culturally diverse societies. In particular, the project pursues 4 objectives:1.to develop a conceptual taxonomy to clarify the liaisons between tolerance, respect and spatial issues;2.to study the ways in which appeals to tolerance have informed the development of spatial policies;3.to investigate the influence of cultural diversities on the interpretations of tolerance in different national contexts;4.to extrapolate from the above studies an overall view of the connections between tolerance and equal respect. Our findings will be of interests to national and international Civil Society Organisations (CSOs), policy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Low cost manufacturing process for selectively plated, 2 shot moulded plastic Interonnectors with IDC and spring beam features' in the context of a Fourth Framework call.

assistant: **Objectives**

Low cost manufacturing process for selectively plated, 2 shot moulded plastic interconnectors with IDC and spring beam features - 2KINTERCON - Of the 38,000 moulding, plating and toolmaking companies in Europe, around 75% are SMEs. However, the end customers for electronics interconnector products such as telephone & computer plugs and sockets, tend to be dominated by larger, often American technology led and owned companies, using traditionally manufactured electronic interconnectors with stamped and selectively plated conductive metal inserts. Over recent years, an alarming trend has developed for European manufacturers in the electronics sector to source electronic interconnectors from a growing number of cheaper Pacific Rim manufacturers. The shift away from European supply has the effect of taking with it the typical traditional supply chain for tooling, metal plating and injection moulding, causing increasing concern to the SMEs sectors involved. Around 98% of the market is currently serviced by these products, with the remaining market split between several moulded interconnector device (MID) production routes, including photo imaging, flexible carrier films, subtractive processes (eg. Iaser ablation), multi-stage moulding and 2 shot moulding. Each of these processes has a significant premium in terms of price and, with the exception of two shot moulding, limited capability for mass production, which has prevented mass take-up of the process, even though there are significant benefits in increased functionality over traditional interconnectors. The industrial objective of the proposed RTD is to provide European SME supply chain companies with selectively plated, two shot moulded electronic interconnector technology, with the following advantages over traditional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Digital Journey across Musical Places in Europe and Extended Realities' (2021-2027) under Horizon Europe.

assistant: **Objectives**

This research project focuses on creating digital applications that enable users to explore significant “places of music” across European regions and cities. The applications aim to provide an interwoven narrative, encompassing the musical event itself, its cultural and historical context, the location, and physical museum objects. This multi-layered storytelling approach will draw upon a diverse range of sources, including musical scores, instruments, chronicles, diaries, letters, philosophical treatises, and images.The project involves geographically mapping musical locations and creating engaging thematic itineraries based on places, people, themes, and historical periods, encompassing a wealth of tangible and intangible heritages. It will be implemented through case studies which will be further adaptable and extensible in the future.The project will focus on developing cutting-edge digital tools to enrich the visitor experience at these places of music through virtual and augmented reality experiences, multimedia accessible through different applications and tools integrated in the ECCCH. This includes a particular emphasis on reconstructing historical soundscapes, as well as the acoustic properties of spaces for musical performances, exploring the interplay between music and architecture, and harnessing the potential of virtual and augmented reality technologies.  Furthermore, the project will create design and simulation tools, conduct analysis and evaluation of the impact of audio-visual communication in museums.To achieve these aims, the project will cater to a diverse audience, encompassing scholars, museum curators, the entire educational sector, creative cultural industries, citizens and tourists.All datasets, metadata, and interaction tools will be Open Sou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Integrated water management of Mediterranean phosphate mining and local agricultural systems'.

assistant: **Concept**

The phosphate industry is a major contributor to the economy of some Medit. countries (Morocco, Jordan, Tunisia, etc). Large volumes of water are required by the mining industry from areas where water resources are scarce or limited. Water scarcity may be worsened by a degradation of the water quality after phosphate processing. The pressure on water is liable to hamper the development of phosphate industry and results in competition with other water reliant economic sectors such as agriculture or tourism. The El'Maa project meets this strategic need: to reduce tensions on water resources (quantity and quality) at regional scale; to consolidate the sustainable development of the phosphate mining industry. El'Maa will focus in priority on the interface betwee n the mining and agricultural sectors, given the economic and social importance of the latter sector. The general objective of El'Maa is to provide the phosphate industry and the water managers with a methodology for the integrated management of water reso urces in the zone of influence of the mine sites and supply technological innovations to reduce the pressure on water resources, in mining (e.g. use of municipal wastewater in phosphate process) and agricultural practices (e.g. use of phosphate process wat er). This methodology will integrate a customised Decision Support System with a realistic representation of water management system, integrating technical, economic, social and environmental dimensions. El'Maa DSS will serve i) to identify and rank the fa ctors controlling water management and sharing; ii) to optimize the water consumption and re-use; iii) to measure the potential impact of changes in the mining and agricultural practices related to technological innovation or evolutions in the institution al o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cell line development platform for SMEs to reduce the length and cost of biologic drug development' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Biologic drugs ($160+ billion market) provide better long-term health outcomes with fewer side effects than many traditional drugs. However, due to high development and production costs, these drugs are 20x more expensive, on average, limiting the access to these therapies and burdening healthcare systems. To a great extent, this is because traditionally flexible and creative biotech SMEs currently lack rational tools for mammalian cell line development (most of the biologic drugs are produced in mammalian cell lines), meaning that large investment in terms of capital and time is required to make a production cell line.ICF, an established player in the biotechnology industry, develops a technology for more efficient development of mammalian cell lines for high-yield protein production. It reduces the need for robotic systems and high-throughput screening facilities (€900 000 -> €200 000), the time (6-12 months -> 3) and cost (€100 000 -> €50 000) of cell line development. These advantages stem from specific landing platforms, predefined integration sites, recombination-dependent insertion and amplification of expression units. The technology will enable biotech SMEs to develop the process of production of new biologic drugs at lower costs and faster, eventually enabling biologic drugs to penetrate more cost-sensitive indications and target groups.IcoCell project is aimed at optimizing the landing platform, generating cell lines compatible with process of development of industrial cell factories, generating regulatory documentation, preparing standard operating procedures, demonstrating the production of different types of proteins and implementing initial exploitation activities.Cell line development market is expected to grow at CAGR of 12.8% (2014-2022) and the market
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Project cluster support - accompanying measure' to be submitted under Fifth Framework.

assistant: **Abstract**

The PRIDE 1 Accompanying Measure is designed to support a group (cluster) of innovation projects with various aspects of their work over a period of two years. This will be achieved through a series of support measures covering the following:* Initial meeting with all projects in the cluster* Creation of a cluster secretariat with e-mail/web communications* Moderated Planning Workshops for all projects in the cluster* Continuous on line" support to projects with a project management software tool for work programme creation and reporting* A series of seminars/workshops (4 x 2 days) covering intellectual property rights strategies, project management, dissemination, exploitation, marketing, financing innovation and experience exchange* Visits to projects preparing their 6 monthly reports (circa 18 over 2 years)* On line telephone and e-mail support on project management, IPR, etc.* Assistance with all non-technical issues, including dissemination of project-specific results through PR campaigns etc.* Gathering of reports/information/good practices on non-technical issues to create synthesis reports* Helping to understand technical issues (through attending workshops and seminars) in the following fields:- technology supply-technology validation-technology adaptation (pilot projects etc.).In doing so, PRIDE 1 will generate a number of benefits, such as* Transnational approaches to problem solving* Contributions to Community objectives, in particular in the areas of innovations and employment, education and training* Lessons learned from past and ongoing innovation projects"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'TACKLING FUNCTIONAL MATURATION FOR TRANSPLANTABLE HEMATOPOIETIC STEM CELL GENERATION' in the context of a Horizon Europe call.

assistant: **Objectives**

Hematopoietic stem cells (HSC) provide a lifelong supply of blood and immune cells. They are a life-saving therapy for leukemia and have recently found broadened applications to gene and cell therapy, against other cancers, genetic, autoimmune, and infectious diseases. Nonetheless, practical limitations, such as donor-matching or insufficient cell number render these therapies unfeasible or unsuccessful for many patients. Attempts to overcome these limitations have been unable to create a reliable source of HSC for patients: while we can generate human HSC from pluripotent stem cells (PSC), they resemble early development stages, lacking the functional maturation hallmarks. FUN-HSC aims at identifying core and actionable maturation pathways for HSCs and at defining the contribution of coordinated gene expression by chromatin regulation, using a combination of functional and genetic screening technologies and high-throughput readouts in vitro and in vivo. HSC maturation occurs in the liver during fetal development and confers functional multilineage hematopoiesis ability throughout adulthood. Using single cell omics analysis of human embryonic and fetal tissues, we describe multiple gene programs changing during developmental HSC maturation. This study will lead to candidate cell-intrinsic and niche-dependent instructions, which will be dissected in the context of the fetal liver, by analyzing the cell compartments and their interactions and by combining novel organoid technologies with mouse xenografts to model the fetal liver environment. Ultimately, we aim to identify a strategy that mimics these pathways in vitro to bring the maturation stage of the PSC-derived HSC, to a robustly engraftable and clinically valuable HSC source. Harnessing new knowledge in human HSC bi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'An All-Optical computer for solving Hard Optimization Problems' in the context of a Horizon Europe call.

assistant: **Objectives**

LightSolver is developing a new paradigm for computing. We have developed a revolutionary Laser Processing Unit (LPU) that outperforms traditional CPUs and GPUs in specific tasks, such as optimizing supply chains, designing new materials, and managing financial portfolios. This new LPU  Laser Processing Unit can process NP-hard problems orders of magnitude faster because it has no electronic gradients inside the processor. This LPU is small as a desktop size, operates at normal conditions, and consumes minimal power. This full-stack unit includes three layers to provide the most accurate solution within the shortest time frame: a user interface, an operating system and Hybrid Hardware. Our proprietary hybrid solver combines an all-optical solver based on a pure laser processing unit (LPU) with a digital enhancement that increases the number of spins (variables) whilst decreasing the complexity of the problem. All industries will benefit from optimization problems, including government, healthcare, financial services, retail, manufacturing, energy and utilities, transportation and logistics, and more. Asset optimization is gaining notable importance in the manufacturing and energy sectors due to the possibility of obtaining real-time data LightSolvers platform offers distinct advantages from competitors: Faster and More Accurate SolutionsCost-Effective Manufacturing and Energy ConsumptionCloud Accessibility and On-Premises CapabilityUnique Assisting AlgorithmsScalability for Complex Problems


**Keywords:** optimisation,  computer science, scientific simulation, quantum mechanics