RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Heparanase inhibitors in antiangiogenic and antimetastatic cancer therapy' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Inhibition of heparanase overexpressed by tumours, preventing not only the release and activation of angiogenic growth factors stored by heparan sulfate (HS) proteoglycans but also the disruption of the basement membrane and the extracellular matrix is regarded as a very promising strategy to develop anticancer drugs. This project aims at:a) mapping the binding sites of heparanase for HS;b) determining the structural requirements of HS-like polysaccharides for interaction with the enzyme as substrates and as inhibitors;c) improving the heparanase-inhibiting properties of polysaccharides by generating specific sulfation patterns optimised on biological activity (inhibition of heparanase, antimetastatic-antiangiogenic activity).These aims will be pursued through a study of the inhibition of heparanase with natural and synthetic HS-like oligo/polysaccharides, glycomimetics, and its in vivo effects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Comorbid Conditions of Attention deficit / hyperactivity disorder'.

assistant: **Concept**

Understanding mechanisms underlying comorbid disorders poses a challenge for developing precision medicine tools. Psychiatric disorders are highly comorbid, and are among the last areas of medicine, where classification is driven by phenomenology rather than pathophysiology. We will study comorbidity between the most frequent psychiatric conditions, ADHD, mood/anxiety, and substance use disorders, and a highly prevalent somatic disease, obesity. ADHD, a childhood-onset disorder, forms the entry into a lifelong negative trajectory characterized by these comorbidities. Common mechanisms underlying this course are unknown, despite their relevance for early detection, prevention, and treatment. Our interdisciplinary team of experts will integrate epidemiologic/genetic approaches with experimental designs to address those issues. We will determine disease burden of comorbidity, calculate its socioeconomic impact, and reveal risk factors. We will study biological pathways of comorbidity and derive biomarkers, prioritizing two candidate mechanisms (circadian rhythm and dopaminergic neurotransmission), but also leveraging large existing data sets to identify new ones. A pilot clinical trial to study non-pharmacologic, dopamine-based and chronobiological treatments will be performed, employing innovative mHealth to monitor and support patients’ daily life. Integration of findings will lead to prediction algorithms enhancing early diagnosis and prevention of comorbidity. Finally, we will screen to repurpose existing pharmacological compounds. Integrating complementary approaches based on large-scale, existing data and innovative data collection, we maximize value for money in this project, leading to insight into the mechanisms underlying this comorbidity triad with its huge burd
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Toughbranching: Discovering how root branching is affected in compacted soil' to be submitted under Horizon Europe.

assistant: **Abstract**

Soil compaction is a major constraint on root growth, reducing lateral root branching and limiting plant access to water and nutrients. While the physical effects of compaction are well documented, the hormonal and genetic mechanisms underlying root responses—particularly lateral root branching—remain largely unexplored. Auxin is a central regulator of lateral root development, but how auxin signaling interacts with mechanical stress to influence branching is not well understood. To address this, I will use state-of-the-art high-resolution X-ray computed tomography (X-ray CT) to examine how lateral root branching is altered as roots grow across compacted soil zones. This approach mimics natural field conditions, where roots encounter heterogeneous soil with randomly present compacted and non-compacted regions.The host lab has made groundbreaking discoveries showing that ethylene accumulation in compacted soil triggers a cascade of signaling events that modulate ABA and auxin signaling to reshape root growth. Recently, the lab published a single-cell transcriptomic analysis of rice roots grown in compacted and non-compacted soils in Nature journal, identifying key auxin signaling genes induced by soil compaction in the pericyle cells from where lateral root development initiates. Building on these findings, I will investigate whether these genes are also involved in regulating lateral root branching under soil compaction. To uncover cell-specific gene expression changes associated with this process, I will apply spatial transcriptomics, enabling the identification of novel genes and pathways that control lateral root development under mechanical stress. This integrated approach will advance our understanding of root branching plasticity in response to soil compaction and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Longevity-focused health management of complex engineered systems' (HEROES).

assistant: **Concept**

The HEROES project proposes a transformative framework for longevity-focused health management of complex assets, shifting the focus from short-term performance metrics to long-term sustainability, reliability, and efficiency. While traditional methods prioritize immediate fault detection, they often overlook the interdependencies and evolving operational loads that influence asset lifespan. HEROES bridges these gaps by developing novel physics-informed machine learning (PIML) techniques to model long-term interdependent degradation and AI-driven, interpretable decision support tools.The framework features a module for modeling, understanding, and forecasting the health evolution of wind turbines and their components under dynamic operational conditions. By developing cutting-edge PIML methods, HEROES predicts degradation, assesses interdependencies, and evaluates lifetime consumption under varying operating conditions. The project leads the way in integrating and developing physics-informed graph neural networks (GNNs) with Neural ODEs, transformers, and hierarchical GNNs, enabling accurate long-term predictions and scalable modeling across components, systems, and fleets.Building on these predictive degradation models, HEROES proposes a pioneering decision support system for longevity optimization. It develops multi-agent reinforcement learning for health-aware control to extend component lifetimes, and optimize design for maintenance through operational feedback and generative models. HEROES further innovatively integrates counterfactual reasoning and neuro-symbolic AI to simulate long-term “what-if” scenarios, providing fully interpretable interaction with decision makers.Validated on wind turbines, HEROES aims to optimize operation and maintenance strategies at com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Virtual european laser institute (VELI)' (VELI).

assistant: **Innovation**

The goal of a Virtual European Laser Institute is the improvement of the accessibility and use of available European expertise and experience on laser technology, mainly for the benefit of SME's in Europe (providing local access to dispersed knowledge), by means of the development and exploitation of a virtual network with major laser institutes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Electrified CO2 Capture using HiGee Vortex Reactors', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The fossil fuel-driven chemical industry is notorious for its massive CO2 emissions and energy consumption, demanding an urgent shift toward cleaner, more efficient technologies, with CO2 capture as a critical component. Existing gas-liquid reactive absorption/solvent regeneration technologies, relying on bulky packed columns or motor-driven rotating packed beds, fall short due to transport limitations and scale-up challenges. e-CAPTURE seeks to revolutionize the field with a scalable and electrified reactor that uses flow kinetic energy to generate powerful centrifugal forces without mechanical rotation, overcoming transport limitations in interphase mass transfer, mixing, and heat transfer, pushing reaction rates to theoretical limits while slashing energy demands. My objective is to build and demonstrate the e-CAPTURE reactor, aiming for at least a tenfold increase in transport-reaction efficiency and a 50% reduction in energy demand over existing systems. To achieve this, I will:1) unlock a deep understanding of transport-reaction fundamentals under extreme centrifugal forces and shear rates, observed with cutting-edge temporal (0.1 µs) and spatial (0.1 µm/pixel) resolutions, via innovative techniques like ultra-high speed imaging and infrared planar laser-induced fluorescence.2) develop a computational fluid dynamics-driven multiscale modeling platform to unravel CO2 interphase mass transfer, turbulence-chemistry interaction, and heat dynamics.3) address design-performance relation of the e-CAPTURE reactor by multi-objective optimization and conduct reactive demonstration for impurities removal, CO2 absorption, and solvent regeneration with integrated Joule heating.Through a synergy of advanced visualization, state-of-the-art simulation, and real-world testing, I w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Heat in the driver’s seat: unlocking the full potential of pulsed photothermal catalysis' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The climate catastrophe urgently calls for greening and intensifying chemical reactors. Most chemical reactors use catalysts to speed up reactions, but their operation at steady-state temperature impairs rate, selectivity, and energy efficiency. To go beyond these limitations, applying short heat pulses theoretically leads to >100× higher reaction yield, lower energy use, and a controlled product distribution. However, pulsed heating has remained out of reach because it is hard to heat catalysts selectively and fast enough.I break this paradigm and take control of dynamic thermo-catalysis by using light pulses and robust “plasmonic” materials that convert light to heat with nanoscale specificity. HEATPULSE comprises three work packages that tackle three challenges: (1) kinetics: modulate pulse timing for controlling reaction rate and selectivity, (2) localization: confine heat at thermal hotspots to boost energy efficiency, and (3) stability and performance: access high peak reaction rates by developing temperature-stable pulsed photocatalysts. Ground-breaking innovations: (1) Access to a normally unreachable reaction landscape, with dynamic tunability of catalyst activity and selectivity; (2) Thermal hotspots break the limit of nanoscale heating and reach 3× higher peak temperatures with exponentially enhanced rates; (3) Metal nitride nano-arrays integrated with single-atom catalysts grant thermal stability beyond 1000 °C.HEATPULSE represents a revolution in green reactor technology by shifting from burning fossil fuels to heat-pulsing with light, powered by renewables. The project will lead to the new field of “photocatalysis beyond the steady-state” at the crossroads of catalysis, nanophotonics, and materials science. With an accomplished track record in nanoscale li
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Coordination Of Maritime assets for Persistent And Systematic Surveillance' (COMPASS2020).

assistant: **Concept**

The external borders of the EU have historically been under great pressure, subject to a variety of threats, which include irregular migration and trafficking of narcotics. Within this context, authorities in charge of border and maritime patrol are faced with different challenges that include the heterogeneity of the traffic that undertakes illegal activities in European waters, limitations in the ability to collect and share timely available data among institutional organizations, as well as a lack of assets by the relevant authorities to cover the wide maritime areas under their mandate. Although there has been an expressive investment done in the domain of surveillance technologies and tools, the intake by the competent authorities has been slow, due to lack of uniformity in the integration of such systems with existing surveillance infrastructures. In order to address these challenges, project COMPASS2020 aims to demonstrate the combined use and seamless coordination of manned and unmanned assets to achieve greater coverage, better quality of information and shorter response times in maritime surveillance operations. The proposed solution will be based on an innovative CONOPS that makes use of multiple aerial and underwater unmanned vehicles with improved capabilities, deployed from OPVs or from land, and will be supported by a central, multi-domain and interoperable Mission System (MS) that enables the operation of these platforms from both locations. UxVs may act as deported ship sensors, providing critical mission data to the MS that can then be exploited through dedicated services to be developed in the scope of the project (e.g. Data Fusion and Threat Risk Analysis). The major goal of COMPASS2020 is to demonstrate an operational solution to ensure long range a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Education and Time-Preference: Causation, Consequences and Intergenerational Effects""' (EDTIMEPREF) targeting Seventh Framework.

assistant: **Abstract**

The scientific content of this research project is concerned with understanding the complex interactions between education, time-preference, mental health outcomes and the transmission of these factors between parents and their children. The research will move our understanding beyond the mapping of correlations between these factors, exploiting large datasets from a number of EU countries, allied with state of the art econometric methodologies, to establish the strength of the causal relationship between education and an individual’s own time-preferences, the time-preferences of their children and the individual’s mental health.Building on the Fellow’s current research skills, experience and competencies, the Fellowship will significantly advance the Fellow along the career path towards securing a leading academic position. The Fellow will be provided with a new and stimulating research environment, working alongside the leading academics in the research field, gaining technical training in new methodologies and being exposed to policy experiment evaluation studies unique to the Geary Institute at University College Dublin. Advanced formal training in complementary skills, plus the technical skills gained and practical experience of project management, will contribute to a rounding of the Fellow’s skill portfolio. The significant advancement of the Fellow’s skills will place him in a position to exploit future funding opportunities in the EU as numerous nations implement policy experiments which will require highly skilled quantitative social scientists to evaluate.  The Fellowship is the next coherent step in the Fellow’s research career progression and will position the Fellow to secure a tenured position at a leading European research institution.Going forward, expo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'A BALKAN AND EASTERN EUROPEAN NETWORK OF EXCELLENCE FOR THE DIFFUSION OF MATHEMATICS FOR INDUSTRY EXPERTISE'.

assistant: **Concept**

MATHIND is a network for mathematics for industry covering the Balkan and CEEC region. The network members comprise university departments with an active interest in mathematics for industry. The problem addressed by the network is the communication's gap between mathematicians and industrial users that prevents the uptake of the latest mathematical techniques by industry within the Balkan-CEEC region. The objectives of the network are to establish a continuous dialogue with industry whereby industry's RTD and training needs can be identified. It is intended to meet these needs through co-operative cross-border research projects, student placements and training activities. Network activities will contribute to the modernisation, competitiveness and convergence of regional industry. MATHIND is a network for mathematics for industry covering the Balkan and CEEC region. The network members comprise university departments with an active interest in mathematics for industry. The problem addressed by the network is the communication's gap between mathematicians and industrial users that prevents the uptake of the latest mathematical techniques by industry within the Balkan-CEEC region. The objectives of the network are to establish a continuous dialogue with industry whereby industry's RTD and training needs can be identified. It is intended to meet these needs through co-operative cross-border research projects, student placements and training activities. Network activities will contribute to the modernisation, competitiveness and convergence of regional industry.OBJECTIVESMATHIND objectives are:a) Motivate mathematical research and research partnership synergies in areas critical to the development of industry in the Balkan and CEEC,b) Develop appropriate communication mech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advancing cell based therapies by supporting implant survival' (ENABLE).

assistant: **Concept**

Tissue engineering aims at the creation of living implants to replace, repair, or regenerate damaged, diseased, or aged tissues, which holds tremendous possibilities to both extend our lives and improve our quality of life. During the last decades, our ability to create small tissues to heal small animals e.g. mice and rats has taken a breath taking leap. However, we have relentlessly struggled to create viable tissues of human-relevant sizes. Creating solid large tissues imposes lethal nutrient diffusion limitations, which causes the living implant to suffer from starvation, loss of function, and inevitable failure. I hypothesize that this key challenge can be tackled by recruiting and developing advanced enabling nano- and micro-technologies. The ENABLE project begins with the design and development of a widely applicable platform that will enable large solid engineered tissues to survive and function by actively sustaining the implants metabolic needs. This platform is based on a unique two pronged strategy that rely on distinct technologies: oxygen releasing micromaterials, fabricated using a next-generation droplet generator, to enable short term survival of the implant, while embedded bioprinting will endow implants with a complex 3D vascular network to enable their long term survival. As proof of principle, the effects of ENABLE’s platform will be investigated using a critical bone defect in which I analyse the survival and function of the created living implants. The anticipated outcomes of this proposal are three fold: first, I will develop a next-generation engineered tissue that will overcome the current size restrictions via the use of enabling technologies; second, I will reveal new knowledge on the role of the oxygen tension on vascularization and tissue f