RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Photoelectron Imaging and Spectroscopy of biomolecules using VUV light' (IMAGINGELECTRONS), addressing dissemination and exploitation.

assistant: **Impact**

The principal aim of this project is to develop a versatile photoelectron imaging (PEI) apparatus capable of measuring both the kinetic energy and angular distribution of photoelectrons emitted from a variety of gaseous molecular and atomic targets in a single experiment. Photoelectron spectroscopy and the angular distributions of emitted electrons are highly sensitive to the electronic structure and symmetry of molecules. To aid the interpretation of the resulting photoelectron spectrum the researcher intends to apply the training obtained in the previous Marie Curie Fellowship on computational methods as well as nurture collaborations with established theoreticians. The novel aspect of this project is the combination of this versatile detector with a range of light sources from a noble gas resonance lamp, synchrotron radiation and a combination of laser + synchrotron radiation. This range of sources will permit a number of targets to be investigated. The first of these targets will be a series of halogenated pyrimidines and purines. This class of molecules (which form model systems for radiosensitisers) is being investigated by a number of other methods from Auger spectroscopy to electron impact spectroscopy within the host institute. The researcher will interact closely with these other aspects to allow a wide ranging investigation of these molecules. In general, the use of the highly sensitive PEI technique in combination with intense third generation synchrotron sources will be sufficiently sensitive for less volatile molecules which may be impossible to investigate using other techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Developing a standard modularised solution for flexible and adaptive integration of heat recovery and thermal storage capable of recovery and management of waste heat' (Smartrec), addressing dissemination and exploitation.

assistant: **Impact**

Waste heat is a problem common to high temperature processing industries as a significantly underused resource, often due to challenges in economic heat valorisation. Secondary aluminium recycling and ceramic processing were identified as key examples with economically recoverable waste heat. Several challenges are inherent; these processes are batch-based rather than continuous with corrosive particulate-laden flue gas over a wide temperature range. The Smartrec system meets these challenges by development of a standard, modular solution for integration of heat recovery with thermal storage that valorises medium to high grade waste heat, adaptable to different temperatures and industries. Following end-user analysis and characterisation of exhaust streams and waste products, full life cycle costing and assessment will be carried out with candidate molten salts selected for thermal storage and heat transfer fluid, validated by corrosion testing. A custom heat pipe heat exchanger will be modelled and designed around the requirements of heat transport capacity wick structure and capable of heat exchange with a molten salt pumping loop. This loop will include dual media thermocline thermal storage system with cost/system modelling, validation and instrumentation incorporated. A pilot Smartrec system will be constructed and deployed in a secondary aluminium recycler and/or ceramic processor valorising high grade heat for continuous energy-intensive salt-cake recycling. Smartrec will be validated by integration with existing systems with >6 months operation including a fully developed instrumentation framework. A knowledge-based tool will be developed containing all relevant Smartrec parameters and information to model the system fully and allow users to determine their requ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Co-ordination mechanisms for Smart Card Charter implementation' to be submitted under Fifth Framework.

assistant: **Abstract**

The eEurope Smart Card Charter (SCC) has resulted in industry approved action plans and steering mechanisms to initiate and support common deployment and specifications for smart cards in Europe.Smart Card provides essential infrastructure and coordination mechanisms necessary to reinforce this momentum and bring the SCC Action Plan to fruitful conclusion.It empowers the Smart Card Charter Steering Committee, enables the High Level Group, involves the Smart Card Constituency, and ensures essential coordination required with and between the twelve Trailblazer initiatives.Benefits will be reduced industry fragmentation increased links with European R&D and relevant standardisation initiatives, and improved interoperability of smart card based systems and services. The resulting increase in deployment and adoption of smart cards will accelerate the development of the digital services economy in Europe.Objectives:The eEurope Initiative has prompted intense European collaborative activity resulting in an agreed Smart Card Charter (SCC) and action plan. By the end of 2000 work culminated in the establishment of a Smart Card Charter Steering Committee with 12 specific application and technology initiatives called Trailblazers, each with aggressive development and deployment plans.Smart Card will provide the essential infrastructure for the SCC Steering Committee to support and enable dedicated expert leadership, a secretariat and website facilities, and an extensive range of short term specialist competencies in a wide range of disciplines which include technology, application and user requirements, marketing and information dissemination. At its conclusion it will have implemented the agreed SCC/SC Action Plan.Work descriptionSmart Card is structured into three work-packages:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Relocating Modernism: Global Metropolises, Modern Art and Exile' in the context of a Horizon 2020 call.

assistant: **Objectives**

Breaking new ground, METROMOD proposes a rewriting of modern art history as a history of global interconnections, spurred by migration movements and rooted in cities. Revising the historiography of modern art, which still continues to be dominated by the hegemonic and normative narratives of (Western) European Modernism and ignores the significance of exile movements, METROMOD conceptualizes art history as a result of interrelations and negotiations in global contact zones, unstable flows, transformations and crises. In its analysis, METROMOD focuses on the first half of the 20th century. During this era the modern movement emerged as a paradigm in art and architecture, and rapid urbanization took place globally; thousands of persecuted European modern artists fled their homes, re-establishing their practices in metropolises across the world. Reflecting both the geographical extent of these exile movements and their local urban impact METROMOD examines 6 key migrant destinations—the global cities of London, New York, Buenos Aires, Istanbul, Shanghai and Bombay (now Mumbai)—following three main objectives:  to explore transformations in urban topographies, identifying artistic contact zones and places of transcultural art production; to investigate networks of exiled and local artists as well as collaborative projects and exhibitions; and to analyse art publications and discourse generated in centres of exile. Digital mapping will locate sites of artistic migration in the cities and demonstrate linkages between transforming metropolises and flows of people and objects around the world. The conceptual triangle of modernism, migration and the metropolis forms the foundation of an innovative comparative, interdisciplinary methodology. As well as impacting art history, METRO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Role of Microtubule Regulators in Centriole Elongation'.

assistant: **Objectives**

Centrioles are cellular organelles made of microtubules that are essential for centrosome, cilia and flagella assembly and as such are involved in a variety of cellular and developmental processes, including cell motility, division and polarity. Centriole biogenesis is first seen during S phase by the appearance of procentrioles that elongate as the cell cycle progresses to reach nearly full length in mitosis. Most mature centrioles in an organism have similar length, yet very little is known on how centriole length control is exerted. The purpose of the current project is to investigate centriole biogenesis, in particular centriole elongation, its kinetics and regulation. We will search for novel molecular players in this process via two complementary approaches. We will perform an RNAi screening of microtubule regulators in mammalian cells and check for their role in centriole elongation. In addition, we will perform pull-down assays using already known molecular players in centriole length control and search for new binding partners by mass spectrometry. These combined approaches will identify novel players in centriole biogenesis that we will further study using in vitro and in vivo (Drosophila) approaches, to better understand their mechanism of action and their relevance to the organism.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Using comparative genomics to uncover the origins of phenotypic modularity in squamate reptiles' (ULTRAMOD).

assistant: **Innovation**

The genomic determinants of morphological change are of great interest to evolutionary biologists, particularly how they relate to the loss and evolution of key traits. Ultraconserved elements (UCEs) are regions of genomes that are highly conserved across distantly related organisms. Many UCEs are located in cis-regulatory (enhancer) regions of the genome that play critical developmental roles in determining morphology; when UCEs are removed notable changes to the skulls and limbs of mammals can occur. These UCEs are highly conserved across vertebrates and the evolutionary loss of a single UCE (Sonic hedgehog limb enhancer) has been associated with partial and complete limb loss in squamate reptiles. However, much of what is known about the causal role UCEs play in development is derived from functional studies, which have only examined a handful of model species. A broader phylogenetic and genomic perspective of how UCEs relate to morphological variation would offer much needed information for interpreting the results of functional studies. Comparative genomics offers a means to dramatically increase the taxonomic sampling of UCEs, both through examination of annotated genomes and comparison of UCE loci obtained using sub-genomic sampling methodologies. I will use UCEs to characterize the enhancer landscapes of squamate reptiles that putatively underpin cranial and limb diversity. I will then relate the dynamics of these genomic landscapes to the modularity and integration of crania and limbs that occur across squamates using 3-dimensional (3D) scan data derived from museum specimens. This project will produce novel sub-genomic data and 3D scans that will be shared in online repositories. I will be aided by my hosts and their world-renowned museum collections to delive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Prediction and assessment of the aquatic toxicity of mixtures of chemicals' (PREDICT).

assistant: **Concept**

Surface waters and aquatic organisms are typically exposed to numerous chemicals simultaneously or in sequence. Consequently, hazard assessment in aquatic toxicology has to include rational approaches to predict possible combination effects. Different concepts allow to calculate expected toxicities of mixtures by analysis of concentration response relationships of their components. The recent report to the Scientific Advisory Committee on Toxicology and Ecotoxicology of the EEC concluded that the concept of concentration addition provides a reasonable basis to predict combined effects of similar acting substances. It should be applied when environmental quality norms are set. However, three questions remain to be answered: - Which criteria shall be used to classify substances as similar acting? - Is the concept of concentration addition valid for the prediction of mixture toxicities on more complex than single species levels? - What are reasonable predictions for combined effects of substances with dissimilar modes of action? The objectives of the research project PREDICT are: - to avaluate the potential of quantitative structure activity relationships (QSAR) for the prospective assessment of mixture toxicities and to optimise grouping criteria for pollutants like the list 1 chemicals of directive 76/464/EEC. - to experimentally validate predictions made from the concept of concentration addition for similar acting substances on a periphyton multispecies community test level, and - to compare the predictive values of the concepts of ,concentration addition and independent action for multi-component combinations of dissimilar acting substances especially for low, non-significant effect concentrations (EC1%) of the individual constituents. D. Calamari & M. Vighi (1991),EE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Wavefunctions for strongly correlated systems' under Horizon 2020.

assistant: **Concept**

Strongly correlated quantum systems, which are at the heart of many open problems in condensed matter,quantum chemistry, or high-energy physics, are challenging to understand due to their intricate entanglementstructure. Quantum information theory provides the right framework to characterize highly entangledstates and has given rise to the class of Tensor Network States, which capture the entanglement structure ofstrongly correlated systems by building the global wavefunction from local tensors and provide an efficientdescription of their low-energy states.In this project, we will develop a framework for the systematic study of strongly correlated systems usingexact wavefunctions based on Tensor Network States. It will give us the tools to construct controlled familiesof states by encoding the relevant structure of the system directly into the wavefunction, rather than aHamiltonian, and to study their behavior. Since the tensor describing the wavefunction also gives rise to anassociated Hamiltonian, this establishes a framework for building solvable models with the tensor as thenew central object.The novelty of our approach lies in the fact that quantum information gives us the tools to systematicallyconstruct wavefunctions for general strongly correlated systems, while at the same time, encoding thestructure of the problem directly into the wavefunction results in small families of states with a directphysical interpretation of the parameters, unlike for fully variational approaches.We will apply our framework to study the physics of a range of strongly correlated models, in particularfrustrated fermionic and spin systems, in order to understand the possible physics they can exhibit. Thiswill enhance our understanding of the physics of strongly correlated systems, and,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development, validation and promotion of advanced non-animal test methods for chemical substances and products (including stem cells)' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Specific Objectives:Development of advanced test methods and testing strategies that could be used to replace, or reduce and refine, the use of animals for the testing of chemical substances, chemical products and biomaterials. Such methods include in vitro systems based on stem cells. Prevalidation and validation of alternative test methods and testing strategies for chemical substances and products, leading to reports on the outcome of (pre)validation studies and weight-of-evidence reviews. Coordination of the independent peer review of validated methods, leading to statements on the scientific validity of alternative methods. Provision of a publicly-available Scientific Information System on alternative methods and their development/validation studies Support to Commission services and other Customers, including: support to DG ENV, the future Chemicals Bureau, and the OECD in relation to alternative methods for chemicals testing support to DG ENV in relation to the Directive on the Protection of Laboratory Animals (Directive 86/609/EEC) support to DG ENTR and DG SANCO in relation to alternative methods for the testing of cosmetic products (Directive 76/768/EEC) support to DG ENTR, the Council of Europe and the EMEA in relation to methods for assessing the safety and efficacy of biologicals and medicines.Anticipated milestones and schedule:Most of the listed milestones/activities should be considered as a continuous process, which will require the whole year 2003. General Establish project management groups for all areas of chemical and cosmetic safety testing. Develop strategies and partnerships to set ECVAM's recent comprehensive review on the use of alternative test methods and testing strategies in relation to the Future EU Chemicals Policy into practice Establish
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A novel muscle disorders 3D in vitro system for drug screening and validation.' (MUSCLEGUY), addressing dissemination and exploitation.

assistant: **Impact**

MUSCLEGUY represents a unique opportunity to commercialize a novel 3D in vitro system for screening and validation of drug candidates to treat muscle disorders. Although skeletal muscle disorders are relatively rare they pose a huge socioeconomic burden. Currently there is a lack of therapeutic options for the majority of patients. This is, for an important part, due to the lack of reliable, reproducible, and physiological relevant in vitro models of muscle disorders that accurately reflect the in vivo reality on which novel therapeutic strategies may be developed.We generated a novel 3D in vitro system of highly matured myofibers, the relevant functional unit of the muscle affected in most muscle disorders and used it to identify novel therapeutic targets of muscle disorders. During MUSCLEGUY, we will further technically optimise our in vitro system to generate human relevant disease models for muscle disorder. Such systems can be used for drug screening and validation. In addition, we will further investigate the commercial feasibility of our product by conducting an elaborate market analysis and establishing a strong IP portfolio. The ultimate aim of MUSCLEGUY is to develop a business plan to convince the relevant stakeholders. Our novel 3D in vitro system for muscle disorder has the potential to meet the requirements for pharmaceutical drug discovery research (HTS format, reproducible and robust) and drastically reduce the associated costs and the number of animals used, in order to further increase the interest of the pharmaceutical industry for muscle disorders.