RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Plant adaptation to heavy metal and radioactive pollution' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Anthropogenic activities continue to impact the environment causing soil and ground water contamination in many regions and the effects are often persistent especially where heavy metals and radioactive substances have been released. Ecological problems can be particularly severe in the case of atomic power facilities and recent occurrences (Japan) indicate that the Chernobyl incident in 1986 was by no means unique. Moreover, such accidents hold a profound “dread” factor for the general population. Environmental pollution can be equally profound and even more persistent in the case of mining waste which contaminates large areas of Europe with diverse heavy metals. Plants adapt to chronic radiation and heavy metal contamination as demonstrated by re-colonization of polluted areas. This project aims to understand the basic principles of protective mechanisms and how such pollution affects the stability of the genome. We propose to establish a research network to evaluate and exploit unique resources in the Chernobyl zone and in mining sites (Wales, UK) as “open area” laboratories for studying how changes of DNA are coordinated with internal cellular networks during plant response to these pollutants. We use a combination of genetic, cell biological, molecular and evolutionary strategies. Part of the project is devoted to crop plants and their ability to grow in contaminated sites with the idea to increase productivity and safety. For the first time, eight research teams with complementary experience in radiation and other plant stresses will cooperate for solving the common for Europe problem of survival in contaminated nature. This will provide the insights on an increasingly detailed knowledge of the regulatory mechanisms for plant stress tolerance and gives an opportun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'SYNBIO.ECM: Designer extracellular matrices to program healthy and diseased cardiac morphogenesis' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

To meet medical needs worldwide, tissue engineering must move from successful pre/clinical products towards an effective process to meet Worldwide medical needs, but this is challenging since a quantitative design framework has not emerged, yet.  Synthetic biology (SYNBIO) was the solution that genetic engineers found to the same problem: “Despite tremendous individual successes in genetic engineering and biotechnology […], why is the engineering of useful synthetic biological systems still an expensive, unreliable and ad hoc research process?” asked Dr. Endy in a 2005 letter to Nature. The SYNBIO solution included: i) libraries of DNA parts with well-characterized effect on cells; ii) tools to computationally design system-level assemblies, or designer-DNA; and, iii) bottom-up engineering of cell functions using progressively more complex designer-DNA. Effectively, SYNBIO introduced a computer-aided design and manufacturing (CAD/M) platform that transformed the process of engineering cells. However, since inputs from the extracellular matrix (ECM) have largely been ignored, progress towards programmable tissue-level behavior have been more modest. Here, we will build on my experience with computational and experimental models in cardiac tissue engineering to develop a CAD/M framework for engineering cardiac tissues with computationally predictable properties, or designer-ECM. To characterize ECM-cell interactions, we will use traction force and super-resolution microscopy with fluorescence in-situ sequencing. To model multiscale ECM-cell interactions, we will use ordinary differential equations and subcellular element models. Finally, we will leverage ECM parts and human induced pluripotent stem cells to bioprint designer-ECM that recapitulate three phases of heart dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Optogenetic decomposition of inhibitory micro-circuits in the mouse V1 and S1' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

GABAergic interneurons are known to play a central role in sensory processing, circuit plasticity in the developing cortex and several neurological disorders. However, the role of specific interneuron subtypes in the emergence of functional properties or in the modulation of spontaneous cortical dynamics is still unclear. In this project, we propose to study interneuron micro-circuits in two primary sensory areas of the mouse.Extensive work has emphasized the role of feedforward thalamo-cortical projections in the formation of orientation tuned cells in the primary visual cortex. However, the precise interplay between these afferent synaptic inputs and the participation of recurrent cortical connections is still largely debated. During the outgoing phase, we will use 2-photon calcium imaging together with fluorescent labeled interneurons and optogenetics technologies to dissect out, in the mouse V1, the specific role of two interneurons subtypes (parvalbumin- (PV+) and calretinin-expressing (CR+)) in the orientation tuning and the emergence of simple-like receptive fields in pyramidal cells.Recent works in the mouse barrel cortex have shown that different interneuron subtypes are correlated to animal behaviors in specific ways. The spiking activity of PV+ cells decreases when the mouse undergoes a transition from a resting state to a whisking behavior whereas other GABAergic cells increase their firing rate. We hypothesize that specific PV- interneurons play a central role in the filtering of sensory information during whisking whereas PV+ interneurons could participate in the emergence of slow oscillations that are present during quiet wakefulness. During the return phase of the project, techniques that have been applied during the outgoing phase will be used to addres
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Building an Ecological Approach for Monitoring Groundwaters'.

assistant: **Concept**

Biodiversity is crucial for maintaining ecosystem stability and environmental health. The anticipated extinction of over one million species in the coming decades poses a grave threat to ecosystem functions and services, particularly in freshwater systems, which are among the most neglected in conservation efforts. Groundwater ecosystems, in particular, are critically overlooked, with less than 10% of known habitats globally protected. These ecosystems, which are highly biodiverse and rich in endemic species,  provide the majority of the world's drinking water. However, their close connection to surface ecosystems makes them especially vulnerable to surface threats such as urbanization, which can raise groundwater temperatures by 3-4ºC. This urban heat island effect endangers groundwater species and the vital functions they support. Despite their importance, research on groundwater biodiversity remains limited due to the inaccessibility of these environments and the challenges posed by traditional sampling methods.This proposal explores the use of environmental DNA (eDNA) metabarcoding to monitor biodiversity in alluvial groundwater ecosystems and link eDNA profiles to species' functional traits. By developing and refining eDNA protocols and building a functional biodiversity library for groundwaters, the research seeks to establish a cost-effective, accurate method for monitoring biological processes in groundwater. Additionally, the study will apply these protocols to assess the impact of subsurface urban heat islands (SUHI) on groundwater communities and their functional diversity. In collaboration with experts from Slovenia, Austria, Denmark, and Guatemala, this project aims to enhance our understanding and management of groundwater ecosystems, ensuring their long-t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'scaling sustainable Anodes for efficIent water ElectroLysis' (ARIEL).

assistant: **Concept**

ARIEL (scaling sustainable Anodes for efficIent water ElectroLysis) seeks to demonstrate and validate a scalable process for the synthesis, activation, and implementation of non-platinum-group catalysts for water electrolysis  a bottleneck on the path to the projected gigawatt deployment of this technology that is needed to meet carbon emission targets. We have previously demonstrated, at the lab-scale, the feasibility and potential of cobalt-based anodes as alternative to iridium in proton-exchange membrane water electrolysers (PEMWE), achieving activity and stability at PEMWE-relevant current densities (Science 384, 1373, 2024). ARIEL aims to build on these results translating original, non-scalable synthesis and manufacturing protocols into scalable processes that retain catalytic activity and stability. The aim is to demonstrate a process compatible with kg-synthesis and activation, prototyping electrodes up to 400 cm2; and externally validating these, as a prelude to the potential commercial exploitation of this invention. ARIEL will further assess the sensitivity of the different parts of the process on reliability, and perform scale-informed technoeconomic and lifecycle analysis to evaluate differentexploitation schemes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Global view of food allergy: opportunities to study the influence of microbial exposure' (GLOFAL).

assistant: **Innovation**

Modern European living conditions are creating a cascade of events that lead to increase in allergies. The changes in food processing, food intake, mucosal permeability and immune reactivity to allergens need to be understood in depth before appropriate interventions are possible. This process may be facilitated with a more global view of food allergies is taken. This, because, allergic disorders have been increasing in prevalence particularly in western countries. If we are to understand why allergies are increasing, we need to study regions that are in transition; with lifestyles that represent Europe one hundred years ago and moving towards lifestyles that resemble modern Europe. By understanding the causes and mechanisms that underlie the apparent tolerance for allergens in some geographical areas where prevalences of allergies are low, one can make knowledge based plans to combat allergic disorders in Europe. However, most studies thus far have been examining inhalant allergies and now food allergies need to be adressed in particular. The estimates of food allergies are considered to be imprecise and much pan-European efforts are being put into applying standardised diagnostic methods to get accurate measures. It is important to plan ahead and aim to build up strong teams that are able to do research in the area of food allergy in regions where allergies are less common. There are currently no medical or paramedical staff with a good perception/knowledge of food allergy. The present proposal aims to bring together a group of European experts in the area of food allergy who will train a number of medical doctors, nurses and scientists from African and Asian centers by organising workshops and laboratory based courses With the view to the future this will stimulate I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Launching the First Non-Invasive Brain-Monitoring System for the Early Detection and Management of Encephalopathy In Preterm Babies' under Horizon 2020.

assistant: **Concept**

Over the last two decades preterm babies (neonates with less than 37 weeks of gestational period) have rise tremendously reaching 15 million births worldwide in 2014, and the figures are growing. Anyhow, despite we have been successful at maintaining alive premature babies until their live it’s not at risk, we are failing at solving important side-problems. Preterm babies are at high risk of suffering encephalopathies (brain damage) during the artificial gestational stage on the neonatal intensive-care units (NICUs). In fact, about 20% of babies born before 6.5 months gestation experience lasting brain damage. This leads to lifelong disorders such as attention deficit, autism, cerebral paralysis, and hearing or visual impairments.To early detect cerebral damage in a precise manner it’s necessary to provide real time and accurate measures of cerebral oxygen metabolism and blood flow in the brain. This problem remains unsolved since current commercial solutions provide partial measurements or are extremely invasive. BabyLux will be the first device allowing early detect and manage encephalopathies in preterm-babies in a non-invasive and affordable manner by combining two leading photonic techniques.Our product fall within the sub-segment of “monitoring equipment” for NICUs, which is a € 1.200M market growing at a CARG of 6.5%.BabyLux will be sold at a first commercialization stage to pre-clinical markets (research institutions studying brain damage in neonates). We will proceed in such way since to gain credibility among scientific community, easing the entrance to clinical segments. At a second commercialization stage we will approach clinical segments, in particular hospitals with NICUs. This mixed business model will allow HemoPhotonics to achieve a turnover of € 13 M
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Methodologies and applications of emission measurements on rotorcraft' in the context of a Seventh Framework call.

assistant: **Objectives**

The air transport industry is paying a lot of attention to growing public concern on the environmental issues of air pollution. Clean Sky is a Joint Technology Initiative that will develop breakthrough technologies to reduce environmental impact. In order to reduce environmental impact from rotorcraft, the Green Rotorcraft integrated technology demonstrator will develop environment-friendly flight paths: they are procedures and mission profiles designed to reduce fuel consumption and NOx emissions. To this aim it is necessary to create a data base containing flue emissions by rotorcraft during flight and in different weather conditions. This data base will be used in order to design green mission profiles; to create complete database, generic rotorcraft will be mathematically modelled to calculate flue gas emissions, by means of state of art numerical codes. Results from numerical codes always need to be validated by extensive test campaign. In this proposal Centro Combustione Ambiente (CCA) proposes as a partner for flue gas emission measurement. In order to perform accurate measurement activity in a not standardized field, CCA will use its broad experience in flue gas measurements from stationary gas turbines. Due to the lack of standard procedures to perform measurements on rotorcraft, CCA will define the most appropriate methodology and the best practices for the measurements of emissions from aeronautical engines. The equipment defined in the methodology will be suitable to operate properly in flight tests. The guidelines from methodology will drive during test campaign to perform accurate measurements of CO, CO2, NOx, SO2 and soot concentration during flight tests. Using data gathered during flight tests, CCA experts will contribute to edit a report with data rela
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Search and monitoring of Harmful contaminants, Other pollutants And Leaks in vessels in port using a swarm of robotic fish' (SHOAL) targeting Seventh Framework.

assistant: **Abstract**

We have identified a cutting-edge method for monitoring pollution in ports as specified in EU Directive 2005/35. This monitoring process is currently costing approximately 350 million Euros per year in the EU. SHOAL will develop a shoal of robotic fish to analyse contaminants in water and produce a real-time map of which pollutants are in the water, in what concentrations and where these are on a 3D map of the port.  SHOAL will use advanced swarm intelligence techniques to control the robots, utilising hybrid particle swarm/ant colony optimisation techniques in order to coordinate the group efficiently and adapt quickly to changes in the environment. This will benefit not only monitoring operations in ports across the EU, but also lead to important advances in robotics, chemical analysis, underwater communications and robot intelligence. At present there are no fully autonomous systems for monitoring pollution in ports. SHOAL is innovative in that it can analyse chemicals not only on the surface of the water (e.g. oil) but also those that are dissolved in the water (e.g. nitrates). This will allow the fish to find pollution from agriculture as well as leaks from vessels in a port.SHOAL will build robot fish which will function independently and as part of a larger group to analyse and monitor pollution in a port. These robotic fish will be equipped with chemical sensors to find pollutants in the water and modems to create an ad hoc network for communication within the swarm. This will allow the shoal of robot fish to build up a broad map of the pollutants moving through the port in real time whilst adapting naturally to changes in environmental conditions in the port. Beyond this, due to the design of the robots, they will be able to search underwater rather than simply
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanics of Energy Storage Materials: Swelling and Fracturing in Lithium ion Batteries electrodes during Charging/Discharging Cycles' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

One of the greatest challenges facing the electric power industry is how to deliver the energy in a useable form as a higher-value product, especially in the area of renewable energy. By storing the power produced from immense renewable sources off-peak (e.g., daytime for solar energy) and releasing it during on-peak periods, energy storage can transform low-value, unscheduled power into high-value “green” products.The development of high-energy and high-power storage devices has been one of the research areas of top-most importance in recent years. Lithium batteries currently have the highest energy storage density of any rechargeable battery technology. Their behavior is based on the classical intercalation reaction during which lithium is inserted into or extracted from both cathode and anode. Huge volume changes are associated with this process, often resulting in disintegration of the material.Exploration of nanostructure is one of the encouraging research directions in order to avoid materials failure. Experiments suggest that size reduction is an effective strategy in creating fracture resistant electrodes.Using a combination of diffusion kinetics available in the literature and fracture mechanics, the first part of project aims at giving insights on the critical size for flaw tolerant nano-structured battery electrodes. Approximated analysis of crack coalescence and debonding at the interface between active particles and porous electrodes will be achieved by means of new ad-hoc multi-physics cohesive interfaces.Since effects at different scales are involved during charge/discharge cycles, the simulation of the mechanical response of Li-Battery systems requires a multi-scale approach. The second part of the project aims at enriching current computational homogeni