RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Developing high-thoughput bioassays for human cancers in zebrafish'.

assistant: **Objectives**

Recently the zebrafish has emerged as a new important system for cancer research because the zebrafish genome contains all orthologs of human oncogenes and forms tumors with similar histopathological and gene profiling features as human tumors.  The zebrafish provides an in vivo vertebrate model for identifying novel mechanisms of cancer progression and for development of new anticancer compounds in a time- and cost-effective manner. The ZF-CANCER project aims to develop high-throughput bioassays for target discovery and rapid drug screenings applicable in preclinical validation pipelines. Fluorescently labelled human and zebrafish cancer cells will be implanted (xenogenic and allogenic transplantation) into zebrafish embryos transgenic for a GFP-vascular marker and quantitative, multi-colour fluorescent intravital bio-imaging of tumour progression will be set up as the readout. Because of its amenability to genetic manipulation and optical transparency, the zebrafish is currently the only vertebrate model that allows the simultaneous in vivo imaging of all hallmarks of cancer progression including cell survival, proliferation, migration and induction of angiogenesis.  The combination of visual, non- invasive monitoring in translucent host embryos with powerful RNA interference technology, successfully developed for human cancer cells will enable identification of novel targets in a wide variety of human cancers. Automation of these fluorescent readouts will accelerate the screening process with chemical libraries to discover new compounds involved in different aspects of cancer progression and inhibition. In the case study, a selected panel of genes and lead compounds will be screened on a high-throughput platform, possibly resulting in the identification of important
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Rapid and Reliable Detection of Foodborne Pathogens by Employing Multiplexing Biosensor Technology'.

assistant: **Innovation**

Pathfinder is a important research project focused on development of innovative means of detecting important pathogenic organisms  associated with food poisoning. This will be achieved using biosensor technology capable of detecting many different pathogens simultaneously. To achieve the main goal the Marie Curie Fellow, Dr. Nitsara Karoonuthaisiri from Thailand will bring her skills in microarrays and pathogen detection and lead a team of scientists at the Host Institute at Queen’s University Belfast. The Fellow will work closely with the Institute Director, Professor Chris Elliott, an eminent European researcher in the field of advanced diagnostics on this two year project at the host institution followed by one year return phase. The outcomes of this research will be extremely important to Europe as food poisoning affects many millions of citizens each year and improved diagnostics has been identified as one of the key topics requiring more research activity. Dr. Karoonuthaisiri has been motivated to apply for this prestigious Fellowship to work in a European centre of excellence to enable transfer of her skills & knowledge to an EU research team.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Underground Large Scale Seasonal Energy Storage for Decarbonized and Reliable Heat' (USES4HEAT).

assistant: **Innovation**

Today, the heating sector is not on track toward achieving the IEA Net-Zero targets: it represents more than a third of the energy demand and it mainly relies on fossil fuels. District heating is recognized as a major solution allowing decarbonization of the heating sector. The integration of large-scale seasonal energy storage, compensating for the mismatch between supply and demand whilst ensuring the service, is key for a wide spread of district heating. USES4HEAT aims to demonstrate innovative, large-scale, seasonal thermal energy storage solutions enabling a future decarbonized and reliable heating supply. USES4HEAT demonstrates, at TRL8 and for a one-year test campaign, two innovative, cost-effective, large-scale, seasonal underground TES units to maximize the availability and resilience of heating supply while reducing energy losses and environmental impact. USES4HEAT seeks to demonstrate the storages as fully integrated units in commercial large-scale district heating networks and industrial waste heat recovery and fulfilling industrial thermal demand. In doing so, USES4HEAT also demonstrates six innovative key enabling components/technologies and their integration with seasonal storages: advanced drilling equipment and remotely controlled machines halving drilling times, innovative layered high-temperature borehole pipes, efficient groundwater heat pumps integrated with aquifer storages, hybrid solar panels and thermal solar collector, and accurate AI-based energy management tools. USES4HEAT will systematically demonstrate the effectiveness and techno-economic-social viability of innovative, large-scale, seasonal energy storages ensuring limited CAPEX, reduced environmental impact and energy losses, efficient integration in district heating and accumulation of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mineral Surface Reactivity' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

This proposal focuses on the new interdisciplinary area known as Mineral Surface Science. Understanding the reactivity of mineral surfaces is fundamental to understanding the interaction of minerals with their external chemical environment, and so is concerned with earth processes as diverse as the crystallisation of minerals in metamorphic rocks, to the interaction of minerals with man made pollutants. The very rapid advances made in the last decade in the experimental study of mineral surfaces, and the fact that computational mineralogy is at the point of being able to realistically simulate mineral surfaces in contact with fluids, makes this conference series timely. The objective is to bring together experimentalists and theoreticians and attempt to define the direction of this diverse subject area, specially with the aim of involving young research workers in an enterprise which will be of increasing importance in the future.The computer simulation of growth, adsorption and dissolution processes at mineral surfaces represents the next major challenge in computational minerology. We expect rapid advances over the next few years, and this underlines the importance of bringing together experimentalists and theoreticians at an early stage. The first meeting will therefore emphasise the nature of the problem, the kinds of questions we are poised to answer, the experimental methods we have at our disposal and the results obtained so far. The current state of computer simulation methods in relation to mineral surfaces will be defined, and realistic goals set for the future. The second meeting, two years later, will emphasise computational models of mineral surfaces and their relationship to experimental results. At that stage we expect to be able to report applications of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Signaling and activation pathways of the NOD-like receptors Ipaf, Nlrp1b and Nlrp12' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

My overall aim is to define the role of NOD-like receptors (NLRs) in immunity and to understand the importance of their signaling networks in health and disease.NLR family members are thought to sense pathogens and endogenous alarmins in intracellular compartments to trigger innate immune responses. Recent progress was made in mapping the signaling pathways of the NLRs Nod1, Nod2 and Nlrp3, but the roles and signaling cascades of most other NLRs remain unclear. Indeed, the NLRs Ipaf and Nlrp1b assemble caspase-1-activating inflammasome complexes, but the molecular events leading to Ipaf and Nlrp1b activation remain enigmatic. Similarly, mutations in the NLR Nlrp12 are associated with auto-inflammation, but the precise molecular functions and signaling networks of this NLR require further study.To increase our understanding of the role and signaling pathways of Ipaf, Nlrp1b and Nlrp12, my first aim is to define the subcellular localization and co-regulated genes of these NLRs in naive and activated immune cells. In the second aim, I will define and validate the interactomes of Nlrp1b, Ipaf and Nlrp12 in immune cells from Ipaf, Nlrp1b and Nlrp12 mutant mice. In my third aim, these results will be used to map the activation mechanisms of the Nlrp1b and Ipaf inflammasomes in macrophages intoxicated with anthrax lethal toxin or infected with Salmonella, respectively; and to define the role of Nlrp12 and its interaction partners in innate immune signaling.To approach these aims, I will combine enabling proteomics approaches such as the proprietary mass spectrometry-based COFRADIC technology and interactome technologies such as MAPPIT with detailed biochemical and cell biological studies in NLR knockout cells and mice.Given the importance of NLRs in infection and autoimmunity,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Coding for Interactive Communication and the Power of Adaptivity', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Error correcting codes allow for reliable transmission of data over unreliable channels. The 70 years of development that went into the study of error correction, following Shannon's ground-breaking paper in 1948, yielded a fairly complete theory with far reaching applications to other theoretical and practical fields. However, many modern communication settings are not simply about transmitting information, but rather operate over many rounds of interactive communication between different parties. Cloud computing, cryptographic protocols, and distributed computing schemes are prime examples of such settings.  Due to the overwhelming success of classical error correcting codes, and because interaction is central in many applications, we strongly believe that the theory of interactive error correcting codes will be transformative.Crafting error correcting codes tailored for interactive settings, as well as understanding their fundamental limitations, is the main goal of this proposal.We will study some of the most exciting fundamental open problems in interactive communication. In particular, this includes computing the rate distance trade-off for interactive coding, and building error resilient schemes for distributed computing.  We will consider a diverse set of ``classical'' questions in the interactive setting, as well as aspects of interactive coding that are unique and have no counterparts in classical coding. Further, we will build adaptive coding schemes which will achieve better rates than non-adaptive counterparts.  Indeed, one of the main powers of interactive communication, and an integral part of this proposal, is adaptivity.  Here, each party can adapt its actions based on previous communication.  As our research draws ideas from several scientific communit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Optimisation, demonstration and implementation of an all-encompassing smart site management system for infrastructure construction and maintenance.' (SmartSite) under Horizon 2020.

assistant: **Objectives**

Highway Resource Solutions (HRS) is an emerging technology leader in the field of temporary worksite safety solutions that can be rapidly deployed. Engaging closely with end-users during the development of its Intellicone® technology platform it became apparent that there is a major need for flexible technologies that can help improve safety as well as improve operational efficiency on temporary worksites. These worksites exist in highway maintenance and major infrastructure construction. In order to mimise disruption these are often confined and continuously changing. As a result it is a challenging to avoid potential harm to workers on foot by moving plant or to prevent high vehicles from hitting over head structures and cables. In order to remain competitive Europe needs to maintain and improve its transport infrastructure. However, as there is limited scope for new roads and railways, there is an increasing pressure on national governments to maximise the capacity of their existing networks to achieve infrastructure upgrades and renewals. SmartSite will provide a technology solution that is easy to use and scalable. It will help the construction industry improve site safety whilst enabling safer interaction between personnel on foot and moving plant. As a result it will help improve productivity which will minimise delays for motorists and helps achieve Europe’s ambituous transport plans for 2030. SmartSite will help HRS achieve exponential growth increasing sales potential within Europe and beyond. The resulting  sustainable competitive advantage will create major employment opportunities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Retrofitting of museums for antiquities in the Mediterranean countries. Case study: the archaeological museum of Delphi'.

assistant: **Objectives**

Objectives The project will study a selection of typical museums in different Mediterranean countries and define their problems in terms of energy consumption, quality of lighting and acoustics, relation of building design, exhibit handling and user behaviour. The aim is to develop guidelines for innovative existing musea with better indoor air quality, maximum visual and thermal comfort, low energy consumption and rational use of energy. The project will focus on the Archaeological Museum of Delphi in Greece, where a major extension is already under construction. The objective is to propose a realistic integrated design solution for the re-arrangement of the existing building, regarding daylighting, passive cooling, natural ventilation, acoustics and enhanced exhibition of objects. Technical Approach During the first stage of the project, a selected number of museums for antiquities from Portugal, Spain, France, Italy and Greece will be considered under four fields of assessment:  Architectural aspects  Energy behaviour  Daylighting and acoustics  Lighting The measurements will be carried out during a summer and a winter period. A similar approach, with much more in depth measurements, will be followed for the Museum of Delphi in the second stage of the project. The analysis will lead to a design phase (third stage) which will be subject to approval by the Greek Authorities and experts in the field. During the final stage of the project conclusions from the three previous stages will be combined to form a set of general guidelines and recommendations which will be prepared for the retrofitting of archaeological museums in the Mediterranean area. Expected Achievements and Exploitation The outputs of this project will be : - A general Questionnaire for assessing museum b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Clearing House for Open Robotics Development' (ECHORD).

assistant: **Concept**

The European robotics industry plays a key role in maintaining our continent's industrial base. The robotics industry is strong, but fragmented and dispersed. In the future, cutting-edge technology resulting from top-level research will be the decisive factor for success. Europe not only has a powerful robotics industry, but can also boast superb research. By drawing on these resources, ECHORD aims at producing new knowledge through advancing the state of the art in selected research foci and developing novel technology from which new products can be derived. Within ECHORD, opportunities for knowledge advancement and technology transfer between academia and industry will be created across the whole continent. This will be achieved through the solicitation of focused, small-size RTD projects, so-called experiments, which can be rapidly negotiated, funded and executed. Via these experiments, ECHORD will bring about a large-scale introduction of robotic equipment into research institutions. This is expected to result in both tangible and measurable out-comes in terms of the accelerated development of technologies, as well as the deployment of robotics technology into new scenarios for the direct application of research results. For ECHORD, three such scenarios have been defined: human-robot co-working, hyper flexible cells, and cognitive factories. The foremost purpose of the scenarios is to define an environment that is both scientifically challenging to research institutions and commercially relevant to robot manufacturers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Modelling the impact of soil redistribution on carbon sequestration in agricultural ecosystems'.

assistant: **Innovation**

The influence of soil redistribution within the landscape on the global terrestrial C budget is poorly understood. Recent studies estimate that between 0.6-1.5 Get C year-1 are sequestered due to burial of soil particles in depositional areas. Despite the advances in understanding that have been made, large information gaps concerning rates and locations of terrestrial sedimentation remain. The uncertainties mainly relate to the lack of information about C storage in terrestrial ecosystems and the lack of adequate simulation models that allow the fate of the eroded carbon to be predicted. The main objective of this project is to increase our understanding of carbon dynamics in agricultural ecosystems by developing the necessary modelling tools. This will be achieved by combining current generation soil redistribution models with models of carbon dynamics. The benefits of this approach arise from the use of spatially distributed models of water and tillage soil redistribution that allow simulation of the pathways of eroded carbon within the landscape and in the soil profile. The implementation of the CENTURY carbon model will allow accurate estimation of carbon budgets and assessment of the magnitude of the sink associated with sol· redistribution. The model will be tested and validated by means of detailed data on radionuclides distributions for three agricultural fields in contrasting environments within the European Union. Using complementary data on carbon distributions will carry out additional validation.The proposed research project fits within the priorities of the 6th Framework Programme of the European Community, more specifically under theme 6.3 - Global change and Ecosystems.The project proposal addresses the issues of thematic priority 1.1 - Carbon and Nitro