RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The holistic understanding of superconductivity in moiré quantum materials' under Horizon Europe.

assistant: **Concept**

Moiré materials are a unique platform to study novel quantum phenomena. Their exotic properties, resulting from electron interactions, present an opportunity to develop novel fundamental knowledge and innovative technologies.Moiré superlattices arise when atomically thin layers are slightly misaligned. Their hybridization creates flat bands – states where electrons have zero kinetic energy. As a consequence, interactions between them dominate the physics. This means that the material’s properties cannot be understood in terms of the individual electrons but as a collective phase that all belong to. Superconductivity, correlated insulators and topology have been reported, but their nature and interplay remain unknown.A great limitation in the field is the lack of microscopic information and the disparity in experimental results that arise from sample inhomogeneity. In this context, local probes are key to unravel the true ground state.STMoiré aims to understand the quantum phases that emerge in magic-angle twisted graphene. STMoiré will explore the unconventional superconducting mechanism and the interplay between correlated phases through an experimental strategy that independently and complementary addresses these open questions. I will do so by means of low-temperature Scanning Tunneling Microscopy and Spectroscopy. STMoiré will benefit from my unique expertise in moiré physics and device fabrication to develop an experimental approach beyond the state-of-the-art that combines high-quality sample engineering, ultra-high-energy resolution and atomically-resolved measurements.The goal is to explore the nature of superconductivity and develop a holistic understanding of the phase diagram. This will significantly contribute to condensed matter physics by deepening our kno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Quantifying behavioural phenotype space: chemistry-to-gene screens and combination therapies', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

A central goal of precision medicine is to tailor treatments for individuals based on their genomic sequence. However, many common diseases are associated with mutations in multiple genes and drugs often interact with multiple targets, making it difficult to go from genome sequence to drug selection. Spontaneous locomotion in the nematode C. elegans provides a model to address fundamental questions about the mapping between chemical and genetic perturbation and complex phenotypes. To take full advantage of this potentially powerful model system, we will develop high-throughput tracking technology, both hardware and software, and use it to measure changes in worm behaviour in response to treatment with small molecules and genome-wide RNA interference. The result will be an unprecedented view of a multidimensional phenotype space in a genetically tractable model animal that will allow us to predict mechanisms of action, discover new gene-behaviour associations, and suggest new indications for approved drugs. We will then analyse this mapping to define design principles for combination therapies and test them quantitatively in vivo. The final aim is to combine automated phenotyping and liquid handling with a genetic algorithm to evolve complex drug cocktails. The result will be a better understanding of the potential of precision medicine and progress towards quantitative methods to realise that potential with combination therapies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Revolutionary OnLine Fermentation monitoring'.

assistant: **Objectives**

Holloid will transform food production based on precision fermentation and microalgae cultures with the world’s most advanced real-time bioprocess monitoring and control platform. The current absence of real-time monitoring systems capable of characterizing different microorganisms and cells in bioprocesses, including their states, hinders breakthroughs in bioprocess production of food ingredients from transitioning beyond the lab, greatly reduces productivity, and leads to frequent waste. Primarily, companies in this area face challenges in 1) quickly detecting low concentrations of spoiler microorganisms to avoid waste and 2) monitoring all microorganisms in large liquid volumes to develop and control new and optimized bioprocesses.Holloid develops a unique bioprocess control system based on groundbreaking high-throughput, automated in-line holographic microscopy. In this project, we will add pre-emptive remote maintenance, upscale secure data management pipelines, and use AI to distinguish microorganisms and their phenotypic states in real-time. Our platform will analyze millions of microorganisms in minutes, identifying even rare populations with high statistical significance. It is the missing key enabling technology, giving food bioprocess engineers the ability to directly monitor the microorganisms present and control production with unprecedented precision. We will deliver actionable insights in real-time that our pilot customers say can double their output while using significantly fewer resources, critically enhancing the quality and safety of fermentation and microalgae products. Our scalable SaaS platform and low-cost sensors will be easily integrated into any production process, making statistically relevant, single-cell monitoring accessible to businesses
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Jules Verne Climatic Wind Tunnel', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Principal characteristics of the facility and of the support offered to users: The Jules Verne Climatic Wind Tunnel was designed by the Centre Scientifique et Technique du Batiment (CSTB) to undertake on a full scale basis a wide range of environmental and climatic studies of structure behaviour. With the large size of the facility the main advantage of the JVWT rely on the possibility to reproduce the different combinations of climatic parameters: wind and its natural fluctuations is recreated and associated with temperature, rain, snow, fog, sun, frost, hail or sand storms, smokes, within an aerodynamic field which reproduces the effective climatic development conditions of the phenomena. The exceptional performances of the simulator allow therefore to set up new research targets in the fields of aerodynamics (turbulent and unstationary), thermal science (with transient response), thermal and hygro mechanics, two-phase flows (including ballistic effects), effluent diffusion, radiation, aeroacoustics and so on... applied to buildings, machines and equipments submitted to climatic conditions of the atmospheric Boundary layer. The present proposal aims to expand availability of the JVWT to european researchers working in the previously mentioned fields. The access offered to the JVWT comes along with free access to all infrastructures (mechanical and electronic workshop, desk room and secretary office...). Researchers working in the JVWT, are assisted by high-level technical teams devoted to the setting-up of experiments (mechanical and electrical achievements), test implementation (instrumentation and acquisition of data) and data analysis. Hosted external researchers are mixed with CSTB teams and benefit from their proficiency and expertise. Quantity of access being of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Generation of human disease models by homologous recombination in human embryonic stem cells' (2002-2006).

assistant: **Concept**

Homologous recombination technique has been applied to murine embryonic stem cells improving significantly our knowledge on the functionality of several genes. Human disease models are very valuable tools for the study of the phenotype as well as potential therapy for genetic diseases.The derivation of mutant mice using the technique of homologous recombination has been essential in the generation of models for human diseases. Despite the success of homologous recombination in mouse embryonic stem cells to study many human pathologies, the morphological, developmental and genetic differences between human and mice pose significant limitations for the use of these mutant animals as models for human disorders.In many cases, the mouse phenotype differs from t hat observed in humans. Human embryonic stem cells are non-transformed cells with the capacities of self-renewal and pluripotency, allowing them to differentiate into a wide range of cell types. Via genetic manipulation, human ES cells can also be used to model human diseases to study the disorder's etiology and pathology.This is especially important where the in vivo animal models have failed to fully recapitulate the phenotype in the human diseases. We propose to generate a model of dilated cardiomyopathy using hES cells by homologous recombination. A single base change mutation will be introduced in the LMNA gene, which encodes the lamin A and lamin C proteins, components of the inner nuclear lamina.This mutation that results in the change of one aminoacid has been associated with a high percentage of sudden death (45%) in affected members of a family, even though all the affected individuals are heterozygous for the mutation. Defining how lamin mutations alter cardiac cell biology will ultimately increase our unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Future Sky Safety'.

assistant: **Objectives**

The EC Flight Path 2050 vision aims to achieve the highest levels of safety to ensure that passengers and freight as well as the air transport system and its infrastructure are protected. However, trends in safety performance over the last decade indicate that the ACARE Vision 2020 safety goal of an 80% reduction of the accident rate is not being achieved. A stronger focus on safety is required. There is a need to start a Joint Research Programme (JRP) on Aviation Safety, aiming for Coordinated Safety Research as well as Safety Research Coordination. The proposed JRP Safety, established under coordination of EREA, is built on European safety priorities, around four main themes with each theme consisting of a small set of projects.  Theme 1 (New solutions for today’s accidents) aims for breakthrough research with the purpose of enabling a direct, specific, significant risk reduction in the medium term. Theme 2 (Strengthening the capability to manage risk) conducts research on processes and technologies to enable the aviation system actors to achieve near-total control over the safety risk in the air transport system. Theme 3 (Building ultra-resilient systems and operators) conducts research on the improvement of Systems and the Human Operator with the specific aim to improve safety performance under unanticipated circumstances. Theme 4 (Building ultra-resilient vehicles), aims at reducing the effect of external hazards on the aerial vehicle integrity, as well as improving the safety of the cabin environment. To really connect and drive complementary Safety R&D (by EREA) to safety priorities as put forward in the EASA European Aviation Safety plan (EASp) and the EC ACARE Strategic Research and Innovation (RIA)Agenda, Safety Research Coordination activities are proposed. F
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Hybrid coupled networks for thermal-electric integrated smart energy Districts' to be submitted under Horizon 2020.

assistant: **Abstract**

HYPERGRYD aims at developing a set of replicable and scalable cost effective technical solutions to allow the integration of RES with different dispatchability and intrinsic variability inside Thermal Grids as well as their link with the Electrical Grids, including the development of innovative key components, in parallel with innovative and integrated ICT services formed by a scalable suite of tools for the proper handling of the increased complexity of the systems from building to Local Energy Community (LEC) levels and beyond, accelerate the sustainable transformation, planning and modernization of District Heating and Cooling (DHC) toward 4th and 5th generation. HYPERGRYD also aims at developing real time management of both electrical and thermal energy flows in the coupled energy network complex, including the synergies between them. Therefore, HYPERGRYD aims at three over-arching General Objectives:    -  To prove Smart Energy Networks as the future of Efficient Energy Management in DHC in synergy with the Electrical Grids in        LEC/Smart Cities of the future,     - To define the roadmap to design and planning of future DHC as well as the modernization of the existing ones in different climates        and RES penetration levels toward 4th-5th generation,      -To demonstrate HYPERGRYD RES-based Enabling Technologies, Smart Energy Grid Solutions empowered by new ICT tools and        services as the key for this evolution.During the project, the HYPERGRYD?s solutions will be implemented across 4 Live-In-the-Labs cases in 3 representative climates provided by the consortium, with special consideration to their cost effectiveness and potential replicability to finally achieve these 3 main objectives. All these tasks will follow the proposed work program activities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Visualizing melting magnetic order and spin fluctuations in the cuprates', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The aim of this proposal is to bring new insight and understanding into the remarkable phase diagram of the cuprates, representing the larger family of unconventional superconductors, by visualizing the process of melting magnetic order and the resulting spin fluctuations (magnons) on the atomic scale.The cuprate phase diagram not only represents many of the long-standing, core problems in physics, but also is remarkably similar to all other families of unconventional superconductors. It is my opinion that a main driving force behind the exotic phases are antiferromagnetic spin fluctuations that might stem from the melting process, but little is known about them and their relation to the exotic phases.With this proposal, I will unveil these key processes on the atomic scale for the first time as existing techniques only probe sample-averaged parameters. Using my innovative, nanofabricated ‘smart tips’ concept, I will develop radically novel spin-sensitive, GHz-compatible scanning tunneling microscopy (STM) techniques to visualize the melting (and fluctuating) order. I will then develop electron spin resonance - STM, to measure and image the spin fluctuations, as well as their relation to pseudogap, charge order, and superconductivity.I will capitalize on my track record in the field of quantum materials (such as having discovered nematic order in iron-based superconductors) and my unique background in circuit quantum electrodynamics and STM to build unprecedented instrumentation that will enable a new, holistic look at the mystery of unconventional superconductors.


**Keywords:** Quantum materials, scanning probe, STM, spin resonance, NMR, unconventional superconductivity, high-temperature superconductivity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Precision Hearing Diagnostics and Augmented-hearing Technologies' (EarDiTech) targeting Horizon Europe.

assistant: **Abstract**

Cochlear synaptopathy (CS) is a recently discovered type of sensorineural hearing loss (SNHL) that compromises the integrity of the auditory-nerve population after ageing, noise-exposure or ototoxicity. This SNHL type occurs before the gold-standard clinical audiogram detects hearing problems and has functional consequences for neural sound encoding and communication in noisy environments. Despite its presumed high prevalence, CS is neither diagnosed nor treated in clinical practice. There is a WHO-identified need for early-diagnosis and treatment of SNHL to reduce the societal and economic burden of hearing loss, and CS-diagnosis falls within this category. In our ERC StG and PoC projects, we developed a robust, encephalogram-based diagnostic test to quantify CS in humans. Based on this test, we individualize hearing-impaired auditory models to design hearing-aid signal processing that compensates for CS. Our model-based, augmented-hearing algorithms can offer an accessible treatment to those suffering from CS and are based on a clever and versatile neural-network architecture that enables real-time sound processing. In this project, we plan to implement our diagnostic CS-test (TRL4) in a portable medical device and perform clinical trials with early-adopters and first-point-of-contact centers to demonstrate its patient benefit and application range in a real-world clinical context (TRL5-6). Secondly, we aim to develop hardware demonstrators that embed our augmented-hearing sound processors. These real-time FPGA processors (TRL5) will be tailored for market-entry in the hearable, hearing-aid and cochlear-implant sectors. Along with consolidating our IP portfolio and setting out a business strategy, this challenge on Medical Technology and Devices will enable us to tran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Enabling personalised diagnosis, treatment, and stratification through whole-body metabolic modelling of an individual’s genome, metabolome, and metagenome.'.

assistant: **Concept**

The increasing availability of whole-genome sequences will ultimately transform medicine into personalised medicine. To realise this potential, we need to understand which of the millions of genetic variants in a person’s genome can alter a phenotype. Genome-wide association studies (GWAS) have associated many genetic variants with thousands of phenotypic traits. Metabolomics has further informed GWAS. However, these methods do generally not consider the biochemical network connecting genetic variants with the metabolic phenotype. Additionally, extrinsic factors, such as diet and the microbiome, also modulate the metabolic phenotype. A computational systems approach is required to untangle this complex interplay. In AVATAR, I shall develop and apply a novel mechanistic computational modelling framework that will significantly expand cutting-edge computational models of whole-body metabolism. The novel in silico models will mechanistically describe the network of genetic variants, genes, proteins, and biochemical reactions, as well as underlying physiological processes that are influenced by microbial and nutrient metabolism. I shall devise a novel algorithm to predict phenotypically relevant genetic variants based on a person’s genome and metabolome. The validated algorithm and the modelling framework shall then be used for two distinct biomedical proof-of-concept studies: the diagnosis and diet-based treatment of inherited metabolic diseases and the metabolic pathway-based stratification of individuals with cognitive impairment. AVATAR will enable novel insights into the genotype-phenotype-environment relationship by enabling systematic mechanism-based analyses of genetic variants, diet, and the microbiome. This ground-breaking, innovative, multidisciplinary project wi