RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'LITHUANIAN MOBILITY CENTRE' (2002-2006).

assistant: **Innovation**

The goal of the proposal is to set-up and make operational the Lithuanian node (further referred as Lithuanian Mobility Centre) of the European network of Mobility Centres with a mission of providing information and assistance to mobile researchers and their families that come to Lithuania and outgoing Lithuanian researchers. The Lithuanian Mobility Centre will act as: point of entry for incoming researchers looking for practical information and guidance; service provider providing proximity assistance directly or through signposting to specialised agencies; first information source to outcoming researchers on practical matters and available assistance in other EU and candidate countries. It is proposed to establish one office in the host organisation - Lithuanian Centre for Quality Assessment in Higher Education. Lithuanian Mobility Centre, on the one hand, will act as a service centre, providing services to mobile researchers. In this function, it will identify relevant information sources, structure, translated and adapt information for specific target groups. This information will be placed on the Lithuanian Researcher's Mobility Portal, the main information tool of the Centre. Proximity assistance services will be developed and provided by the Centre staff or signposted to specialised service providers. On the other hand, Lithuanian Mobility Centre perform the functions of bridgehead organisation: creating informal local network with hosting institutions and other organisations, developing and maintaining links with European Mobility Network, ensuring sustainability of the Centre activity, etc. It is proposed to create mobility network consisting of actors related to the mobility of researchers at national level. This will ensure mutual understanding and exchange o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cross-kingdom investigation of the mammalian retroviral silencing suppressor Tas to identify novel silencing factors' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

RNA silencing is a fundamental process controlling gene expression in eukaryotes. Although a set of core proteins that initiate and execute RNA silencing have been identified, the complexity of the pathways involved suggests that additional components are yet to be discovered. In particular, negative regulatory pathways of RNA silencing remain poorly understood, although evidence for their existence has recently emerged. Such pathways are likely to be recruited by viral suppressors of silencing.The goal of the project is to unravel novel silencing factors conserved across kingdoms and to characterize their function paying particular attention to involvement in negative regulatory pathways. We will exploit our recent finding that the mammalian retroviral suppressor of silencing Tas is functional in both human cells and plants. A combination of genetic, functional genomic and biochemical tools will be used to identify host proteins that are targeted by Tas in both Arabidopsis and human cells. Their implication in the various silencing pathways will then be investigated.For example, the plant system will be exploited for its amenability to forward genetic analysis by screening directly for mutations in host genes that alleviate silencing suppression conferred by Tas. Likewise, the conserved function of Tas across kingdoms allows powerful filtering of functional genomics data obtained in both systems, facilitating identification of host targets relevant to RNA silencing pathways.Altogether, this project will illuminate key aspects of the biology of RNA silencing and open new avenues to further investigation of this important research field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Virtualization of Real Flows for Animation and Simulation' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Besides their application in a very broad range of engineering disciplines, physically-based simulations have become a prevalent tool for all forms of computer-generated environments. Simulations of fluids are a particularly important area that has applications ranging from the design of aerodynamic bodies to the realization of impressive visual effects in movies.  However, despite their extremely wide-spread use there are fundamental problems: a lack of practical flow capturing technologies and the inherent difficulties of resolving crucial features such as turbulence. These issues are show-stoppers preventing the area from realizing its full potential for animations and interactive environments.The goal of this research is to address these central problems: 1) by designing novel data-centric approaches for fluid simulations to enable re-use, and 2) by establishing an innovative pipeline for capturing flow motions yielding details that were previously unachievable.  To this end, I plan to design algorithms that tightly integrate accurate  physics solvers with methods for the reconstruction of motion from volumetric images. At the same time, I will work on novel structured representations that decompose complex flows into hierarchical space-time structures. These structured virtual counter-parts will not only enable powerful avenues for intuitive editing, but will also serve as a basis for robust and efficient data-driven fluid simulations. This virtualization of flows opens the door for interactive design tools and medical applications, allowing to incorporate complex physical constraints.  In addition, this research could radically change the way we work with synthetic and captured flow data, and has significant potential to break new ground in terms of data-centric w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The role of cell-to-cell variability in pneumococcal virulence and antibiotic resistance' under Horizon 2020.

assistant: **Concept**

Within clonal bacterial populations not all cells exhibit the same phenotype, even though they grow in the same environment. The molecular sources contributing to phenotypic variation are diverse and can originate from noise in gene expression to heterogeneity in growth rates or cell cycle state. Phenotypic variation helps pathogenic bacteria to elude the host immune response or resist antibiotic pressure. Vice versa, there is cell-to-cell variability in the host’s response towards pathogens that can be exploited by bacteria. How the combined cellular heterogeneity of both host and microbe contribute to infection outcome is poorly understood. The role of phenotypic variation on antibiotic resistance development is also unclear.Recently, we developed novel single cell imaging systems as well as genetic engineering and screening platforms for application to the important opportunistic human pathogen Streptococcus pneumoniae. In addition, we generated a dual-transcriptomics overview of pneumococcal infection of human lung epithelial cells and setup collaborations to perform several infection models. This now places us in an excellent position to investigate the mechanisms and the importance of single cell behaviour for pneumococcal virulence and antibiotic resistance.The driving hypothesis of this application is that the combined heterogeneity of host cells and pneumococci influences infection and antibiotic therapy outcome. To test this, we will use innovative approaches for infection biology by combining synthetic biology and quantitative single cell biology including single cell RNA-seq, CRISPRi, engineered bistable switches and microfluidics. We will reveal the molecular mechanisms underlying cell-to-cell variability and its importance in virulence and antibiotic resis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Jewish women in pre-modern Italy: Magic, medicine and the inquisition' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The comprehensive objective of JeWit is to provide the first historical reconstruction of Jewish women’s everyday life and material culture in medieval and early modern Italy based on medico-magical traditions related to procreation, childbirth and other matters associated with the female body. Despite recent advances in the study of Jewish magic, gender, and Jewish-Christian relations, integrated in-depth research on Jewish women through the lens of medico-magical texts and from a perspective which considers local, oral-aural, and cross-cultural dynamics of knowledge transmission has been mostly neglected. Using a sophisticated methodology which integrates for the first time in-depth analysis of different types of sources (i.e. Jewish and non-Jewish manuscripts, archival documents, material and artistic evidence), JeWit seeks to: a) make accessible for the first time in a commented edition a selection of the most relevant manuscript excerpts on Jewish childbirth techniques circulated in pre-modern Italy; b) detect patterns of continuity, rupture and change in the dissemination of Jewish medico-magical lore related to childbirth during the shift from late antiquity to the medieval era and in the transfer from the East to the West; c) assess the boundaries between Jewish magic and science in medieval and early modern Italy; d) unravel traces of the sense of childbirth as experienced by pre-modern Italian Jewish woman that occasionally survive encapsulated in the texts, thus contributing to a more inclusive intellectual and cultural history of Italian Jewry and fostering large-scale debates on women’s well-being, diversity and inclusion, religious and cultural identity. After prestigious postdoctoral positions in Israel, the U.S., and Europe, a MSCA-PF at EPHE in Paris un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Community method for the detection and diagnosis of potato brown rot - pseudomonas solanacearum' (1994-1998).

assistant: **Innovation**

The major aim is to provide a harmonised scheme for the detection and diagnosis of Pseudomonas (Ratstonia) solanacearum, the potato brown rot pathogen which will be used to support the proposed EC Potato Brown Rot Control Directive. Potato brown rot disease has recently become established in several Member States and poses a major risk to potato production in the EU, affecting the seed potato, ware potato, and potato processing industries. The success of implementation of the Control Directive depends on having reliable diagnostic methods with adequate sensitivity and specificity. Because of its recent establishment in the EU, such tried and tested methods are not yet available. Early work will develop and evaluate a series of methods with potential for detection of the pathogen in all the substrates covered in the Control Directive. These include potato, tomato and weeds (biotic substrates) and soil, irrigation and surface water, potato waste and sewage (abiotic substrates). Much of this early development will be on sample preparation rather than on the methods themselves, because we have methods which work quite well on pure cultures of the bacterium but not, for example, in potato tissue, soil or water. The methods with the best potential for each substrate will be selected and further refined if necessary. These methods will then be evaluated for each substrate in over 30 laboratories throughout the EU. Parallel but smaller studies will evaluate methods for identifying and confirming cultures of the pathogen, also a process demanded by the Control Directive. Another small study will develop and evaluate kits for rapid detection of the pathogen in symptomatic plant tissues, which will be of use during statutory inspections especially of imports from known infected th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Computing Phase Diagrams of Binary Nanoalloys' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The geometrical structures and chemical ordering (mixing/segregation) of binary nanoclusters (nanoalloys) are critical in determining their physical properties and their chemical reactivity – including their catalytic activity. The variation of these properties with cluster size and elemental composition, as well as temperature, are therefore of significant technological interest. In this project, we propose to carry out an extensive study of several key, representative binary nanoalloy systems within a unified methodological framework, combining zero Kelvin minimization and finite temperature Monte Carlo simulation, in order to obtain quantitative phase diagrams. An important aspect of the project is the combination of theoretical research carried out in the laboratory of the scientist in charge with experimental electron microscopy measurements performed by one of the collaborators within the host institution, the University of Birmingham.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Probing many-body localization dynamics using ultracold fermions in an optical lattice' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The question of how an isolated quantum mechanical system thermalizes is not only significant in condensed matter physics, but it also invokes the intriguing problem of the apparent loss of information in a complex system as it thermalizes. A curious case is when a complex system fails to thermalize altogether -- a phenomenon known as many-body localization (MBL). Here, we propose to use interacting ultracold fermions in a lattice to experimentally study the distinctive properties of MBL using a novel set of observables. Among the questions in MBL debated intensely today are those concerning the existence of a many-body mobility edge, many-body intermediate phase and localization in higher dimensional lattice systems. Moreover, the striking relation between non-ergodicity and Hilbert space fragmentation is also not fully understood.In this view, our research objectives include: [1.] Stark many-body localization and Hilbert space fragmentation. We plan to study MBL in a tilted lattice, i.e., a Stark Hamiltonian and study non-ergodicity resulting from Hilbert space fragmentation.[2.] Bipartite fluctuations in an MBL system of >100 lattice sites: We propose to characterize the localization properties using bipartite fluctuations which is a proxy for the Entanglement entropy of a 1D lattice.[3.] Approximate theories for fermionic MBL systems:  Due to the exponential Hilbert space dimension of an interacting many-body system, studying their properties numerically is also exponentially hard. We plan to use a quantum simulator with >100 lattice sites develop efficient approximate theories to describe these systems.The aforementioned projects are easily accessible to the current experimental capability and they will enhance our general understanding of MBL physics. Moreover, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Gromov-Witten Theory: Mirror Symmetry, Birational Geometry, and the Classification of Fano Manifolds' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The classification of Fano manifolds is a long-standing and important open problem.  Fano manifolds are basic building blocks in geometry: they are `atomic pieces' of mathematical shapes.  We will take a radically new approach to Fano classification, combining Mirror Symmetry (a circle of ideas which originated in string theory) with new methods in geometry and massively-parallel computational algebra.  Our main geometric tool will be Gromov-Witten invariants.   The Gromov-Witten invariants of a space X record the number of curves in X of a given genus and degree which meet a given collection of cycles in X; they have important applications in algebraic geometry, symplectic topology, and theoretical physics.  We will develop powerful new methods for computing Gromov-Witten invariants, and will apply these methods to Fano classification and to questions in birational geometry.


**Keywords:** Mirror Symmetry, Gromov-Witten Invariants, Fano Manifolds, Birational Geometry, Computational Algebra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Electronic, structural and optical properties of the rare-earth-metal fullerides' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

During my reintegration period in Prof. G. A. Kourouklis group (Aristotle University of Thessaloniki, Greece) we plan to study multinary alkaline-earth/lanthanide fulleride salts mainly by means of optical spectroscopic techniques like Raman and luminescence as a function of pressure and temperature. This work is a natural extension of our explorations during my initial M. Curie fellowship in Prof. K. Prassides group (University of Sussex, UK) on these systems which present the possibility of strong coupling between two electronically active sublattices, p(C60) and 4f,5d(rare-earth). Indeed, the rare-earth fullerides exhibit magnetic ordering at low temperatures or electronic phase transitions accompanied by remarkable structural response upon cooling and high-pressure application due to the fragility of the valence states of the lanthanide dopants.As a first step we intend to study the Eu6-xSrxC60 (x: 1-5) compounds using the Raman technique at ambient and low temperature in order to investigate the exact role of the C60 molecular cages in their transitions to ferromagnetic states bellow 14 K, characterized by indirect lanthanide exchange interactions modulated by the C60 anions. Moreover, we plan to further elucidate the origin of the Ln2.75C60 (Ln: Sm, Yb ) fullerides structural anomalies under external perturbations like pressure and temperature, as well as the consequences of the Sm or Yb valence transitions on the electronic and vibrational properties of these compounds using accordingly the optical techniques mentioned above.As a continuation of this project and based on the experience gained during my initial M. Curie fellowship, we will work on the isolation and study of the vibrational, electronic and structural properties of the (Ln1-xLn and apos;x) yC60 and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Molecular-genetic mechanisms of extreme adaptation in a polyphagous agricultural pest'.

assistant: **Objectives**

Generalist (polyphagous) herbivores can feed and reproduce on many different plant species and include some of the most pesticide resistant and notorious pests in agriculture. An evolutionary link between host plant range and the development of pesticide resistance has been suggested. Although crucial for devising efficient crop protection strategies, the mechanisms underlying rapid adaptation are not well understood, especially in generalists. The spider mite Tetranychus urticae is a global pest known to feed on 1,100 different hosts from 140 plant families, including most major crops. With experimental advances and new tools developed for T. urticae, we are now poised for fundamental advances in understanding the molecular genetic make-up of adaption in generalist pests. We will generate a large collection of fully inbred and resistant mite strains and describe the sampled genomic variation in the context of selection and adaptation. We will study gene regulation mechanisms and quantify cis versus trans regulation of gene expression on a genome wide scale. We will then create a unique population resource that will allow us to map master regulators of gene expression and construct a gene-regulatory network of adaptation responsive genes. In a highly replicated experimental evolution study, combined with Bulk Segregant Analysis (BSA), we will uncover, without a prior hypothesis, the genomic loci that underlie complex cases of resistance and plant adaptation. A core set of adaptation genes will be validated by functional expression and high-throughput interaction assays. Further validation will come from the development of genome editing tools. In summary, POLYADAPT will exploit the genomic tools now available for spider mites to elucidate regulatory and causal variants