RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Historical Grounding of Migration Decisions of the People at Environmental Risks'.

assistant: **Objectives**

The HoMe (Historical Grounding of Migration Decisions of People at Environmental Risks) project will provide insights on historical reasons of migration decisions (to migrate or to not migrate) of people at environmental risks. Current research on environmental migration claims that mostly the poor are migrating due to disaster. However, motivations of environmental non-migration go beyond resources constraints and are understudied and not yet understood as migration decisions. The factors contributing to non-migration are supposed to be not simply the inverse of those that motivate to migrate. Rather it is assumed, non-migration is also influenced by the settlement history of a community. Going beyond the state-of-the-art, this project will develop for the first time an analytical framework using Ostrom’s socio-ecological system framework for examining the historical grounding of migration decisions. Second, it will model how changes of the social, political and environmental conditions over time influence migration decisions using agent-based modelling. Third, the model will be used to explore possible future migration decisions based on alternative scenarios of changing societal and environmental conditions in the future making use of the findings from the influence of the historical grounding. This novel and timely study will significantly advance scientific knowledge on environmental migration and the respective modelling capabilities, particularly in the emerging field of 'Environmental Non-Migration'. Results will provide a major contribution to global adaptation policy frameworks, including the SDGs and the EU’s Agenda on Migration. The realisation of this cutting-edge project will substantially support the applicant to achieve higher level of professional matur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'New methods to evaluate the impact of single point protein mutation on human health'.

assistant: **Innovation**

The Single Nucleotide Polymorphisms (SNPs) are the main cause of the sequence variability in human. For this reason, the prediction of the impact of SNPs is one of the most challenging problems in computational biology and bioinformatics. The increasing growth of the genome-scale studies is providing a large amounts of SNP data, allowing the application of rigorous statistical approaches for predicting whether a given single point mutation has an effect on human health. In spite of the scientific effort, the identification of disease-associated human SNPs remains a difficult task and a satisfactory solution of general applicability is yet unavailable. This proposal is focused on the study of those SNPs, called missense SNPs (mSNPs), that are responsible of single protein mutation, because the mSNPs can be related to the insurgence of pathologies decreasing the stability or the functional activity of the protein. The main aim of this project concerns the development of new machine learning based methods to predict the effect of a given single point protein mutation. A set of mSNPs corresponding to proteins with known with atomic resolution will be collected and studied evaluating the evolutionary information retrieved using the protein sequences and the structural information derived from the protein 3D structures. The description of the structural and evolutionary related features will allow the implementation of more accurate predictors able to discriminate between disease causing or neutral polymorphisms. In a second part of the project, the resulting predictors will be also used to elucidate the relationships between mSNPs and the resistance to a given drugs. This aspect will be vary important in order to evaluate which therapy could have better effect on a particula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'AD4: 4D Virtual Airspace Management System'.

assistant: **Concept**

Future scenarios do not simply involve an increase in air traffic; new forms of co-operation and co-ordination are expected to emerge and new flight and control schemes and procedures will come into operation through the utilization of precise Satellite p ositioning. A new 4D technology, called D4 to differentiate with the existing 4D ATM concept - creates new opportunities in the way the controller will visualize and interact with information: adding a 4D metaphors in terminal area might help perceptua lly the management of a funnel-like" space an enhancement of a tube inclined perspective, typical of current ATM systems. New ways of representing the information, while not necessarily decreasing workload, provide an opportunity to reduce existin g knowledge gaps, supporting optimal decisions making. The AD4 proposal target to build an innovative Virtual Air-Space representation for ATM system, providing valuable benefits to support efficient control systems where 3D real time interaction with air traffic/airport space is accessible to the controllers. Shared views of information and inter- operability between ground and on-board systems can allow workers to cooperate, managing efficiently complex operations. AD4 will be based on extensive reu se of a technology called D3 (D-Cube), developed in a successful National project co-funded by the Italian Space Agency. Such open technology supports dynamic management and scalable data elaboration for DEM, Meteorology, Pressure and Wind fields, Radar tracks and Telemetry data using auto-stereoscopic displays and 3D mouse devices. D3 will be improved by 4D constructs, supported by Model Driven Architectures and Secure middleware, data-fused with real ATM systems and validated in a European ATM cente r. Specific Human Factors pri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CONtaminants in Food and Feed: Inexpensive DEtectioN for Control of Exposure.' under Seventh Framework.

assistant: **Concept**

RASFF alerts show that monitoring of chemical contaminants in food and feed is very relevant in European food safety. Also consumers placed chemical contaminants on top of the “worry-scale” of food-related risks. According to the General Food Law, food and feed industries are responsible for the safety of their products. Often expensive instrumental single-analyte methods are being applied by regulatory and industrial laboratories. There is an urgent need for replacement by validated screening tools which are simple, inexpensive and rapid, but also show multiplex capability by detecting as many contaminants in parallel as possible. The CONffIDENCE proposal has been designed to provide long-term solutions to the monitoring of persistent organic pollutants, perfluorinated compounds, pesticides, veterinary pharmaceuticals (coccidiostats, antibiotics), heavy metals and biotoxins (alkaloids, marine toxins, mycotoxins) in high-risk products such as fish and fish feed, cereal-based food/feed and vegetables. A balanced mix of novel multiplex technologies will be utilized, including dipsticks, flow cytometry with functionalised beads, SPR optical and electrochemical biosensors, cytosensors and metabolomics-like comprehensive profiling. After validation, the simplified methods will be applied in impact demonstrators that contribute to exposure assessment and validation of hazard models. Moreover, hazards of emerging contaminants will be assessed through toxicological testing. Dissemination to scientists and to relevant stakeholders, including the food and feed industry, regulatory control bodies, DG-SANCO, EFSA, exporting countries, CRLs, routine laboratories, CEN and consumers will be assured by e-communication, press releases, public workshops, open days, presentations, publica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exercised breastmilk: a kick-start for childhood obesity prevention' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Innovative preventive strategies are urgently required to halt the rising prevalence of childhood obesity given the inefficacy of current interventions. Mother-to-child transmission of obesity accounts for a large proportion of childhood obesity, more than what can be explained by genes. Nutrition during the first 3 months of life is crucial, with rapid weight gain in this period associated with subsequent obesity. Breastmilk is considered optimal for infant nutrition, but its composition depends on the mother’s metabolic health: the concentrations of some breastmilk compounds linked to infant obesity are associated with maternal body mass index. Maternal lifestyle factors, such as diet, can alter breastmilk composition. Little is, however, known about the effect of exercise during lactation. Exercise is a major regulator of systemic metabolism affecting multiple tissues and organs. In this ambitious, inter-disciplinary project, I will determine how exercise during lactation influences breastmilk composition in women with overweight/obesity and whether exercise-induced changes in breastmilk will influence infant obesity risk. My preliminary data show acute effects of exercise on breastmilk concentrations of adiponectin and lipid metabolites relevant for energy metabolism. In ExMilk, I will determine both acute effects and adaptations after regular exercise on a complex matrix of breastmilk compounds. By linking breastmilk data to comprehensive data for the infants, I will investigate the potential mechanisms underlying the effects of maternal exercise on infant obesity risk, mediated by changes in breastmilk composition. To reach my goals, I will perform gold-standard randomised trials and analyse biological samples from mothers and infants on multi-omics platforms. My
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Inflammatory and genotoxic effects of engineered nanomaterials' (NANOSH) under Sixth Framework.

assistant: **Objectives**

Nanotechnology is a rapidly increasing area of industry providing new and innovative solutions into many industrial sectors. The challenge faced by policy makers and the scientific community is that very little is actually known about the health effects of nanoparticles. It is essential that reliable information should be gathered before these particles enter widespread use to avoid potential health problems induced by the exposure to workers and consumers.The overall goal of this research project is t o characterize features of specific engineered nanoparticles, to the delineate levels of exposure in occupational environments, and to explore health effects of exposure to these particles. Exposure levels will be evaluated under laboratory conditions and in occupational environments. The particles will be characterized with respect to their size distribution, solubility, surface activity, and potential for agglomerate formation. Health effects to be studied include genotoxicity and inflammatory response s. Genotoxicity will be assessed in relevant pulmonary cells measuring DNA and chromosomal damage. Inflammatory responses will be evaluated by measuring alterations in the panorama of pulmonary inflammatory cells as well as expression of biochemical markers of inflammation, i.e. cytokines and chemokines in vivo. To assess the effects on the vasculature, the potential of nanoparticles to induce pro-inflammatory or prothrombotic effects in the microcirculation of experimental animals will be explored.Assuring the safety of new nanomaterials will be a crucial prerequisite for successful promotion of nanotechnological innovations and their applications in the future. This research aims at creating a reliable and sound foundation for the assessment of safety of nanoparticles,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The future of geometric quantisation' (FGQ), addressing dissemination and exploitation.

assistant: **Impact**

Geometric quantisation is a fundamental link between classical and quantum mechanics, and especially between the key roles of symmetry in these types of physics. It has been studied intensively since the 1980s, and has led to important new insights into the relation between classical and quantum mechanics, and the mathematics underlying these fields. However, the way geometric quantisation has been studied so far fundamentally only applies to classical phase spaces and symmetry groups that are compact. Compact sets are bounded and have other convenient properties that make geometric quantisation considerably easier to deal with, but preclude most applications in mathematics and physics.A generalisation to the noncompact case would lead to a staggering potential for such applications, but also requires a completely new approach to the problem, as the techniques used traditionally become meaningless. There have been some first results using ad-hoc approaches that allow certain amounts of noncompactness, but none have the general and far-reaching applications that should be possible if a general theory of noncompact geometric quantisation is developed. This is exactly what I intend to do. The first steps taken have laid bare the challenges of noncompact geometric quantisation, and the time is now ripe to achieve ground-breaking results, using a completely new and general approach.The key feature of this approach is the integration of the mathematical fields symplectic geometry (which describes classical mechanics), representation theory (which describes symmetry in quantum mechanics), and noncommutative geometry (which is a powerful tool for studying complex classical and quantum mechanical phase spaces). First results combining these fields indicate that this integration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Functional studies on the cytochrome-type nitrite reductase of thiosphaera pantotropha' (1994-1998) under Fourth Framework.

assistant: **Objectives**

As a key enzyme of the biological nitrogen cycle, bacterial nitrite reductase (cytochrome cd1) reduces nitrite but it also catalyses the reduction of oxygen to water. Cytochrome cd1 serves as an ideal model in elucidating three fundamental questions in biology: - How do electrons move between haem groups? - How is nitrite reduced to nitric oxide? - How is oxygen reduced to water?  Based on the first crystal structure of cytochrome cd1, isolated from t soil bacterium T. pantotropha, the structural/ functional properties of this enzyme will be studied via various spectroscopic and electro- chemical methods.  Visible spectroscopy, especially stopped-flow experiments, will elucida the kinetics and catalytic mechanisms of this enzyme with respect to its nitrite and oxygen reducing capabilities. The effect of various substrates and inhibitors will be studied using the wild-type, specifically designed mutants and metal-substituted species.  In addition, redox-titrations and cyclovoltammetry will be used to stud the thermodynamics of inter- and intra electron-transfer processes between haem groups.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biomass to chemicals: Catalysis design from first principles for a sustainable chemical industry' to be submitted under Seventh Framework.

assistant: **Abstract**

The use of renewable feedstocks by the chemical industry is fundamental due to both the depletion of fossilresources and the increasing pressure of environmental concerns. Biomass can act as a sustainable source oforganic industrial chemicals; however, the establishment of a renewable chemical industry that iseconomically competitive with the present oil-based one requires the development of new processes toconvert biomass-derived compounds into useful industrial materials following the principles of greenchemistry. To achieve these goals, developments in several fields including heterogeneous catalysis areneeded. One of the ways to accelerate the discovery of new potentially active, selective and stable catalysts isthe massive use of computational chemistry. Recent advances have demonstrated that Density FunctionalTheory coupled to ab initio thermodynamics, transition state theory and microkinetic analysis can provide afull view of the catalytic phenomena.The aim of the present project is thus to employ these well-tested computational techniques to thedevelopment of a theoretical framework that can accelerate the identification of new catalysts for theconversion of biomass derived target compounds into useful chemicals. Since compared to petroleum-basedmaterials-biomass derived ones are multifuncionalized, the search for new catalytic materials and processeshas a strong requirement in the selectivity of the chemical transformations. The main challenges in theproject are related to the high functionalization of the molecules, their liquid nature and the large number ofpotentially competitive reaction paths. The requirements of specificity and selectivity in the chemicaltransformations while keeping a reasonably flexible framework constitute a major objective. The work w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'SOS - Science on Screen' to be submitted under Seventh Framework.

assistant: **Abstract**

Everyday we are flooded with scientific terms: in the media, at the supermarket, at the pub with our friends. But who makes this science? And how is it done? How is a scientists’ everyday life? Who better to set things straight than scientists themselves?Using amusing but accurate real life stories, this proposal aims for the production of a television show, to be broadcast on the 23rd of September 2011 in a national television channel. The TV show will include scientific stand-up comedy, previously recorded street interviews with the general public on scientific subjects, a section specially dedicated to the International Year of Chemistry, true reports of real scientists' everyday life, and a award-giving ceremony to an outstanding young Portuguese scientist.The proposal also includes build-up activities, starting in April 2011 and going up to the Researchers' Night. These activities will be developed in the national Ciência Viva Science Centers Network, spread throughout the country, drawing the public's attention to the main event. On the night of September 23rd, these Science Centers will also develop local activities, in coordination with the televised event.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Objectual Memory: Remembering Objects by Simulating the Past'.

assistant: **Objectives**

Much attention in our theorizing about the mind has been devoted to episodic memory. In episodic memory, a subject remembers an event from their personal past in a way accompanied by conscious imagery, typically from the first-person perspective, through which they 're-live' the experience. Other species of memory are no less significant to our mental lives, however. We remember objectsfor example, one's first car, or one's childhood family dogand we do so in ways which may outstrip our memory of events in which those objects featured. It is possible, for example, to remember a face while having no sense of where in one's past one's memory of it derives. While we presently lack a philosophical account distinctive of what I will call 'objectual memory', the raw materials are there for the taking. This project will use state of the art, 'simulationist' approaches to memory in order to address this lacuna, establishing the following core hypothesis:  Objectual memory is not a mere form of episodic or semantic memory (Work Package 1). We can best understand it, in harmony with broadly simulationist approaches to remembering, as a kind of epistemically informed imagination (Work Package 2). Though broadly simulationist in character, this view is compatible with experiences of objectual memory constituting a direct relation to the past (Work Package 3).  This project has immediate implications for philosophy of mind and epistemology, but it also generates questions for the sciences. If objectual memory is to be considered a product of the so-called 'episodic' memory system, it is misleading to think of this system as a means of constructing temporally structured episodes from ones past. For the system also produces occasions for the awareness of past objectsthings which lack