RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Cellular interactions in peripheral immune regulation'.

assistant: **Concept**

The immune response is a potent defensive reaction within the organism that can lead to deleterious self-damaging effects in absence of control mechanisms. The modulation of the immune response is exerted at many different levels including T cell-mediated immuno-regulation. Regulatory T cells (TR cells) have recently been identified which have the capacity to control the activity of effectors T cells. Operationally, TR cells are defined by the ability to suppress the expansion of pathogenic naive T cells in vitro and to inhibit inflammatory reactions in mouse experimental systems. However, the mechanisms by which TR cells mediate immune-regulatory events are poorly described. In fact, it is not known whether this TR cell mediated suppression requires a direct cell-to-cell contact between TR cells, Antigen Presenting Cells (APCs) and target Tcells. Furthermore, the stochiometry of the cellular interactions, the dynamics of such interactions and the site(s) of in vivoimmune regulation are largely unknown. The aim of this project is to characterise the cellular interactions occurring during immune regulation events in vitro using the suppression assay system, and in vivo by analysing intact organs of different animal models of immune regulation. Conventional and multi-photon confocal microscopy will be applied to visualise invitro and in vivo interactions of APCs with CD4+CD25+ TR cells and naïve (effector) T cells previously sorted by flowcytometry, from Yellow Fluorescent Protein and Cyan Fluorescent Protein transgenic mice, respectively. These experiments will be designed to assess (1) whether CD4+CD25+ TR cells suppress naïve T cells by direct interaction or through an indirect effect via APCs, (2) whether the CD4+CD25+ TR cell-mediated immune regulation occurs at the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Fostering Learning and Adaptation through Predictability'.

assistant: **Concept**

The FLAP project explores the intricate relationship between environmental predictability, early-life conditions, and avian cognition. Environmental predictability refers to the consistency of environmental cues linked to responses, while cognitive abilities include flexibility, inhibitory control, and attentional focus. We hypothesise that birds’ early understanding of predictability can have lasting effects on their cognition and temperament. FLAP examines this question across ontogeny (how cognition is shaped by environmental factors in individual development), mechanism (how predictability affects cognition and what changes can be observed), and function (how cognition adaptations enhance fitness). We designed two research streams: one focusing on individual interactions with the environment (WP1 and WP2) and the other on the role of social dynamics (WP3 and WP4). Our models—domestic chickens, Northern African ground hornbills, and both Rhinoceros and Helmeted hornbills—enable an unprecedented comparative study across these diverse avian species, marking the first time such an approach has been undertaken. By combining insights from precocial chickens and altricial hornbills with unique breeding styles, we can understand how different life history strategies influence an individual's ability to respond to environmental (un)predictability. FLAP also provides insights for welfare and conservation combining foundational knowledge with applicative perspectives: although our models occupy opposite ends of the conservation and management spectrum, they similarly require intervention to address human-induced environmental changes. Overall, FLAP creates a powerful synergy poised to yield groundbreaking findings in both fundamental science and applied animal welfare, generat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New integrated precision machinery system for soil treatment & sowing & fertilisation & non-chemical weed control for growing of row cultivated crops' under Fifth Framework.

assistant: **Concept**

The SME Coordinator has invented an automatic guidance system enabling conventional implements to be operated with a very high accuracy and speed. The Second SME Proposes comprise a major German machine pool and a highly respected Swedish farmer. The SMECoordinator has made agreement with the Danish lnstitute of Agricultural Sciences (DIAS) Andréa Engineering A/S (WEA) to act as research partners. WEA is at present engaged in 3 EU-financed projects within renewable energy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Single Particle Cryo-EM Reconstruction with Convolutional Neural Networks' under Horizon 2020.

assistant: **Concept**

Electron cryo-microscopy (cryo-EM) is the fastest growing technique to explore the structure of biological macromolecules. To limit radiation damage, images are recorded under low-dose conditions, which leads to high levels of experimental noise. To reduce the noise, one averages over many images, but this requires alignment and classification algorithms that are robust to the high levels of noise. When signal-to-noise ratios drop, cryo-EM 3D reconstruction algorithms become susceptible to overfitting, ultimately limiting their applicability. The algorithms can be improved by incorporating prior knowledge. The most widely used approaches in the field to date incorporate the prior knowledge that cryo-EM reconstructions are smooth in a Bayesian approach. However, in terms of information content, the smoothness prior reflects poorly compared to the vast amount of prior knowledge that structural biology has gathered in the past 50 years. I aim to develop a computational pipeline that can exploit much more of the existing knowledge about biological structures in the cryo-EM structure determination process. I will express this prior knowledge through convolutional neural networks that have been trained on many reconstructions, and use these networks in novel algorithms that optimise a regularised likelihood function. Similar approaches have excelled in image denoising and reconstruction in related areas. Preliminary results with simulated data suggest that significant improvements beyond the existing methods are possible, both in computational speed and in signal recovery capabilities. The proposed methods will enable faster computations with less user involvement, but most importantly, they will extend the applicability of cryo-EM structure determination to many more samples
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Establishing Services Enhancing the Innovation Management Capacity of SMEs in North Rhine-Westphalia, Germany' under Horizon 2020.

assistant: **Concept**

This project is to be understood as an integrated component of the Enterprise Europe Network activities in North Rhine-Westphalia for the years 2015 -2016. For this period ZENIT will undertake - as part of the future NRW.Europa project - the additional task of ""Enhancing the innovation manangement capacities of SMEs"".This task consists of two service packages pre-defined by the European Commission / EASME and foreseen for a limited number of enterprises:1. Beneficiaries of the SME Instrument of Horizon 2020 (Key Account Management, KAM)2. SMEs with significant innovation activities and a high potential for internationalization (promising SMEs with gaps in the innovation management systems).Whereas the first action is reserved for beneficiaries of the new SME instrument with a dedicated coaching scheme, the second is targeted at highly promising innovative enterprises, which will be assisted with a two-step support scheme:1. Recording, analysis and evaluation of the individual status quo and of fundamental requirements and possibilities as well as of the threats and risks of the participating enterprises (analysis of needs and gaps, SWOT analysis).2. Development and implementation of individual concepts, measures, and activities (action and / or coaching plan). ZENIT considers a combination of self-assessment and interview with a senior consultant to be the most effective solution for the first stage and to fulfil the requirements of CEN / TS 16555-1 (innovation management system). The ZENIT Self Assessment tool will be used as priority, other tools like IMP³rove, Steinbeis or N-Bank will be introduced to meet specific needs of SMEs. ""


**Keywords:** Two Consultancy Services for SMES: a) Key Account Management for SMEs participating at the SME-instrument, b) Innovati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Development of an animal feedstuff additive on the basis of micro algae and essential oils to stabilise the immune status of agricultural livestock'.

assistant: **Innovation**

There are a lot of possibilities to replace antibiotics as growth promoters. In this project we want to develop feed supplements based on MicroAge's and spice oils to stimulate the immunsystem. We want to check this supplements by poultry, pigs, calves and lambs. The past trails is have shown that it is possible to stabilize the immunstatus by animals with MicroAge's and spice oils. We want to bring these results in a practicable Product. This product had a market mainly in Europe but in other countries to. The animal feedstuff industry is on the lookout for the development of new production systems, which takes the requirements with profitability, consistent management of resources, product quality and employment as well as animal protection specifications sufficiently into account.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Encapsulation and contacting of two-dimensional materials'.

assistant: **Innovation**

Two dimensional materials such as graphene and transition metal dichalcogenide (TMDC) are very sensitive to surface adsorbates and thus require proper encapsulation. In addition, functional devices based on those materials, like transistors, diodes or electro-optical modulators require high-k gate dielectrics to be deposited on top of the material. However, the deposition of high quality dielectric layers ontop of 2D materials is very challenging due to their inert surface. The project ECOMAT addresses the important challenge of depositing high-k dielectrics on top of 2D materials. In particular, the experienced researcher Dr. Barbara Canto will explore different routes to encapsulate graphene and MoS2, which is the most explored TMDC material, with different high-k dielectrics using a combination of atomic layer deposition and surface functionalization using seed layers.  The key control parameters for those layers are dielectric constant, breakdown voltage, charge traps, minimal thickness achievable, and gas barrier properties, which will be characterized by electrical and spectroscopic methods. Finally a new route for fabricating low-resistive edge contacts to MoS2 will be explored, building up on encapsulated MoS2 layers. This contacting scheme is expected to significantly reduce contamination of the MoS2 layer during processing, while offering low-resistive contacts and thus will significantly increase the performance of electronic device based on MoS2.This interdisciplinary research activity builds up on the experience of Dr. Canto in the field of material science and physics and utilizes the infrastructure and knowledge at AMO on high-k dielectrics and electronic devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Auditory Processing in Insect Brains' (AUDITORYFLY) targeting Seventh Framework.

assistant: **Abstract**

Acoustic signals are used to communicate in many species. It is found from insects to humans to, for example, locate preys, in courtship behaviour or to transmit more complex information to other individuals. To use auditory cues efficiently animals must be able to recognise species-specific sounds. This means that the auditory system is tuned to these sound patterns. Current models assume that sound recognition occurs through matched sensory filters along the auditory pathways, but the identification of neurons with these properties has proved challenging. A characterisation of the auditory system, from sensory input to behavioural output, is currently missing in any animal.Here we proposed to study these mechanisms in simple model systems: the brain of Drosophila fruit flies and honeybees. We will first take advantage of the small brain and of the powerful genetic tools in Drosophila to identify single neurons in the auditory brain centres. Drosophila use auditory signals during their very robust courtship behaviour. We will first record in vivo from neurons and characterise their auditory responses using whole-cell patch clamp recordings while playing natural courtship sounds. With these experiments we will identify neurons responding to species-specific sound features. Second, to identify new neurons in the auditory centres of Drosophila we will use a new tracing methods based on photoactivatable green fluorescent proteins. Here we will discover the higher order targets of auditory neurons in the brain. Finally, we will use intracellular and optical imaging methods to identify neurons in the auditory centres of the honeybee. We will take advantage of studying brain structures involved in a sophisticated communication mode (waggle dance) but in a simple organism. Our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Shoe Information Network' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

This project has the general objective of adopting broad solutions and novel tools aiming at developing the innovative capacities of SMEs of a traditional sector such is the footwear and auxiliary industry, through the implementation of IS based systems which will allow to establish new work procedures.The fields covered by the proposal are:- CAD/CAM as source of value chain integration;- Shoe data management systems, as derivation from big systems used in other sectors;- Quality management systems based on the internet for decentralised organisations (companies with production, sales, design, in different places);- Support to shoe vendors and integration with productive sites through mobile systems.An additional objective of the project is to perform an exercise of defining a pilot action of a future Integrated Project according to EC criteria towards the shoe industry (or traditional industries). This proposal offers good advantages for doing that, as it involves industrial partners, technology sectorial centers, dissemination centers and provides strong potential to develop a project definition study under good complementariry criteria.Objectives:The specific technical objectives of the project are:- To integrate specific CAD solutions for shoe components and shoe design and manufacturing, aiming at the reduction of time in the creative process by 60%;- To improve the exchange of technical data between companies (shoe data management, quality data management, technical support to vendors);- To speed up the process of sales-start up of production by 20%;- To design and implement specific design-production-quality management methods for companies involved in the implementation of the new work procedures;- To reduce the costs of pre-series production by 50%;- To decreas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Structured attosecond pulses for ultrafast nanoscience'.

assistant: **Objectives**

Light is one of today’s most powerful tools for exploriLight is one of today’s most powerful tools for exploring nature at the frontier of the human knowledge. The rapid development of laser technology allow us today to generate ultrashort pulses of coherent structured light: light fields with custom spatial and temporal properties, such as intensity, phase and angular momentum. The later one represents one of the most interesting light properties nowadays, as topological light beams carrying angular momentum interact with matter differently, introducing mechanical motion to micro and nano-structures, and affecting fundamental excitation rules. High-order harmonic generation (HHG) stands as a unique mechanism to provide coherent flashes of light with outstanding properties: its radiation spectrum expands from the vacuum ultraviolet to the soft x-rays; it can be synthesized in pulses as short as several attoseconds (10^-18 seconds): and it can be structured in its angular momentum properties. This proposal represents a timely opportunity to explore the ground-breaking opportunities offered by attosecond structured x-ray sources. It conveys computing light-matter interaction in extreme conditions, which requires an extraordinary effort in the elaboration of new theoretical tools to design, propose and guide future experiments at the frontier of ultrafast science. We shall pioneer the new scenario of angular momenta in structured ultrashort x-rays –the most complex coherent pulses to date–. It is not difficult to envision a new era in ultrafast nanotechnology that makes use of these x-ray sources. In particular we shall pioneer their application to nanoscience and ultrafast magnetism. We aim to establish the grounding principles of attomagnetism, taking advantage of the un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dietary fat, body weight control and links between obesity and cardiovascular disease' (FATLINK) under Fourth Framework.

assistant: **Objectives**

Cardiovascular disease is a major health problem in Europe, causing 50% or more of all deaths at considerable cost to health services. Obesity is a growing problem in Europe, and as the population becomes more obese so an increase in obesity-related diseases, especially cardiovascular disease and type 2 diabetes mellitus, is to be expected. Therefore a better understanding of the origins and treatment of these common conditions must be important both in public health terms and in terms of advice to, or treatment of the individual. Both cardiovascular disease and obesity must represent the result of interactions between genetic and environmental factors. Both have increased rapidly in the present century, over a period when the gene pool in Europe is unlikely to have changed significantly. On the other hand, not all people develop these conditions despite many common environmental factors throughout Europe. A clear example is seen from the results of the Europe-wide MONICA study: death-rates from cardiovascular disease vary widely in different parts of Europe, even when adjusted for factors such as obesity. The overall working hypothesis for FATLINK is that dietary fatty acids are an important mediator of the development of obesity and cardiovascular disease, and that a greater understanding of the effects of dietary fatty acids, in terms of their role in regulation of gene expression and their metabolic pathways in different tissues, will enable us to provide more soundly-based nutritional advice, to develop new pharmacological treatments for these diseases, and possibly to develop new foods with specific physiological functions aimed at combating the development of these conditions. In parallel, we propose that the effects of very-low-calorie diets and exercise program