RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Resistance factors in cancer chemotherapy' (1998-2002).

assistant: **Concept**

The research objectives are to isolate, characterise and exploit, cDNAs encoding novel proteins that are involved in the resistance of mammalian cells to the toxic effects of one class of chemotherapeutic agents which is in common use in the treatment of various types of cancer. I will use well characterised cell lines that have been generated in the host institution by serial selection with increasing doses of such an agent. DNA microarray or subtractive hybridisation strategies described below will be used to isolate cDNAs encoding novel resistance factors. cDNA transfer and expression in bacteria and human cells will allow characterisation of the protein and the effects of its expression in vitro and in cell culture. The demonstration that the factor/s can indeed confer human cell resistance to the killing effects of these agents will be the major objective of the work. I will also examine if the cells have altered responses to other classes of agents (cross-resistance) and if expression affects other biological responses such as DNA repair, mutation and clastogenic effects. Exploitation of these findings will include the generation of antibodies for assessing protein expression in tumour and normal tissues sections in relation to response to these agents and the development of antisense strategies for reducing the levels of the protein in tumour cells to increase sensitivity to these agents. These studies will complement, and benefit from, the very extensive work by the host institution on other drug resistance pathways and the manipulation of these, both to increase the sensitivity of tumour cells and to increase the resistance of normal cells to the killing effects of these agents.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Dual Function Polymer Materials for Blood Contacting Applications'.

assistant: **Concept**

Surface-induced thrombosis and infection are two main complications which cause failure of medical devices. Device-related thrombosis is associated with activation of blood clotting and platelets adhesion and activation. Infection of the implanted devices occurred as a result of bacteria adhesion to the biomaterial surface. A genuinely biocompatible polymer for blood-contacting devices should have both antithrombotic and antibacterial functionalities as both types of complication lead to an increase in morbidity, extended hospital stay and mortality.In order to prevent device-induced thrombosis and infection novel dual function polymer materials - thromboresistant and antimicrobial, will be produced. A novel and original approach that involves construction of multifunctional coatings, which combine formulation of the NO-generating surface with the ability to prevent bacterial adhesion, capacity to inhibit platelet adhesion and the use of surface bound argatroban drug to inhibit any surface-produced thrombin, will be applied. The polymer matrices chosen for the design of dual function materials are the most commonly used synthetic polymers polyurethane (PU) and polyvinylchloride (PVC) and the biopolymer collagen. This aim will be achieved by: i) chemical attachment of the organoselenium or copper nanoparticle catalysts to the polymer surface in order to continuously generate NO by decomposition of endogenous S-nitrosothiols; ii) immobilisation of the direct thrombin inhibitor argatroban to inhibit any thrombin in the surrounding environment. Catecholamines, polydopamine and poly(norepinephrine) will be used as the surface modification reagents, as they form very stable thin films strongly attached to the polymer surface. Owing to the chemical bonding of the ligand to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Disarming the silent threat of ovarian cancer' (DISARM) targeting Horizon Europe.

assistant: **Abstract**

Ovarian cancer (OC) is the most lethal of female cancers, often termed a “silent killer”. DISARM’s overall approach to tackle the significant gaps in hereditary OC management lies in tackling both key elements of risk assessment and early detection. The project will investigate multifactorial risk assessment versus standard practices in 4 EU Member States (MS) (Lithuania, Portugal, Czech Republic, and Greece), and will upscale and validate  a set of easy-to-use, highly accurate and affordable technologies in five countries (UK, Lithuania, Portugal, Czech Republic, and Greece). Several intelligent digital assets will optimally support and enhance our clinical studies, while a range of multifaceted activities will ensure the future uptake and adoption of DISARM solutions. The project aligns with the Innovation Action character of this topic by focusing on both mature technologies that can be upscaled in routine healthcare and on emerging technologies that have already shown a potential to justify larger scale validation activities. Our ultimate ambition is to holistically investigate the preconditions and set the stage for rolling out proven solutions in routine OC risk assessment, and in parallel to create further evidence for the introduction of novel promising elements in early detection programmes. DISARM gathers 26 partners from 12 countries (10 EU MS, the UK and Canada), thereby exhibiting a significant geographic coverage, strengthening European and international collaboration and ensuring widespread diffusion of the project results. This action is part of the Cancer Mission cluster of projects on ‘Prevention and Early Detection (early detection heritable cancers)


**Keywords:** Ovarian cancer, genetic predisposition, risk assessment, early detection, liquid biops
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dissemination of results concerning the integrated production and exploitation of biological materials for non-food uses' (1998-2002).

assistant: **Innovation**

To disseminate the periodic and final results of new (FP5) Renewable Biomaterials projects funded under FP5 Key Action 1.5.2, as well as the final results of approximately 200 projects funded under the FAIR Green Chemicals and Polymers Chain. In addition, a valuable resource of more than 1000 files containing results of around 500 projects and 2500 contacts from previous framework programmes (ECLAIR, AIR, JOULE and THERMIE) would continue to be made available to 4500 existing users on an internet site (NF-2000, previously funded under FAIR-1904). This information is not available in an easily accessible form from any other source. The resource will be of value both to the Commission services and to a targeted audience that includes administrators, scientists, industrialists, Sees, farmers, consumers and others interested in Non-Food Uses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Chemistry and Biology in Synergy -  Studies of hydrogenases using a combination of synthetic chemistry and biological tools' (CaBiS).

assistant: **Innovation**

My proposal aims to take advantage of my ground-breaking finding that it is possible to mature, or activate, the [FeFe] hydrogenase enzyme (HydA) using synthetic mimics of its catalytic [2Fe] cofactor. (Berggren et al, Nature, 2013) We will now explore the chemistry and (bio-)technological potential of the enzyme using an interdisciplinary approach ranging from in vivo biochemical studies all the way to synthetic model chemistry. Hydrogenases catalyse the interconversion between protons and H2 with remarkable efficiency. Consequently, they are intensively studied as alternatives to Pt-catalysts for these reactions, and are arguably of high (bio-) technological importance in the light of a future “hydrogen society”.The project involves the preparation of novel “artificial” hydrogenases with the primary aim of designing spectroscopic model systems via modification(s) of the organometallic [2Fe] subsite. In parallel we will prepare in vitro loaded forms of the maturase HydF and study its interaction with apo-HydA in order to further elucidate the maturation process of HydA. Moreover we will develop the techniques necessary for in vivo application of the artificial activation concept, thereby paving the way for a multitude of studies including the reactivity of artificial hydrogenases inside a living cell, but also e.g. gain-of-function studies in combination with metabolomics and proteomics. Inspired by our work on the artificial maturation system we will also draw from our knowledge of Nature’s [FeS] cluster proteins in order to prepare a novel class of “miniaturized hydrogenases” combining synthetic [4Fe4S] binding oligopeptides with [2Fe] cofactor model compounds. Our interdisciplinary approach is particularly appealing as it not only provides further insight into hydro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Physical Unclonable anticounterfeit tags using Nanotechnology' (NanoPUF).

assistant: **Concept**

The problem: 119 billion EUR worth of counterfeit and pirated goods were sold in the EU in 2022 (Europol/EUIPO). Counterfeiting of goods remains a challenge for our society, increasingly so in a globalised world with long supply chains. Concurrently, the market for sensitive goods, such as medicine has also increased, further exemplifying the need for anti-counterfeit measures. The WHO estimates ~ 100,000 children under five die annually from taking counterfeit pneumonia medication. Current anti-counterfeit measures include tamper-proof seals, security numbers, RFID tags, colour-shifting inks as well as holograms etc.. However, current strategies to prevent counterfeiting of authentic goods are proving inadequate. The lack of a simple and robust way of verifying the authenticity of a product is causing economic and human harm. Simply put, the features in current physical authentication tags are clonable.The solution: We propose first steps towards the commercialization of nanotechnology-based unclonable physical tags which can be attached to product packaging and authenticated via a 3D-printed portable microscope. This will result in cheap, reliable and fool-proof encryption AND cheap, reliable and fool-proof decryption. Our work, having advanced in the past years from a visionary idea to a prototype, offers an anti-counterfeit packaging solution and can become a part of the supply chain logistics in industries from pharmaceuticals to luxury goods and even for currency.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The challenges of diversity for current societies: Its impact on social capital and well-being through the lens of identity' (DIVID) under Seventh Framework.

assistant: **Objectives**

Today, widespread availability of transportation together with the globalisation of job markets and changes in current economies has increased the numbers of immigrants in Europe and around the world. Societies are in constant flux, and have become more diverse than ever before. It is thus not surprising to see, within the social sciences (and also in politics and public debate), concern about the impact of these changes for societies. In fact, this increasing concern has escalated to pessimism about the possible effects of diversity and multiculturalism. Robert Putnam (2000) in his book Bowling Alone showed that in diverse communities, people tend to have less trust in neighbours, lower political efficacy, lower levels of voter registration, and are less likely to work on community projects and contribute to charity. Since then, this negative view of diversity has been voiced across multiple social sciences (e.g., economics, sociology, and political science). The present project proposes to evaluate critically these pessimist findings. First, the increasing mobility of people around the world sets a range of challenges that clearly require certain forms of both identity change and development of new identities for individuals and their societies. Although this is a crucial topic underpinning concerns about diversity and multiculturalism, identity processes have been neglected in previous work. The project will adopt a social identity approach to examine when and why diversity has negative implications for societies. Second, it is vital to understand how current policies manage diversity and counteract the decline of social capital. The project will develop analyses of practical benefit to leaders and policy makers responsible for managing the broad range of identity-re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Density functional theory of electron-ion mixtures - phase transitions in liquid metals' (1994-1998).

assistant: **Concept**

Research objectives and content The main objective of the proposed project is developing Density Functional Theory (DFT) based techniques to study phase transitions and related phenomena in inhomogeneous electron-ion mixtures such as liquid metals. The proposed methods extend ideas from classical DFT to coupled electron-ion systems by treating the electrons quantum-mechanically, the ions classically, but both by DFT. The first application will be the melting of simple metals; the main ingredients have already appeared in the literature,and need only to be combined into one general theory. Experience gained with the melting problem will guide applications to other phenomena in inhomogeneous electron-ion liquids such as solid-solid transitions, fluid-fluid and fluid-solid interfacial phenomena etc...; problems that currently can be treated only by a classical DFT constrained by simple effective potentials. Training content (objective, benefit and expected impact) The current experience of the applicant has been in classical liquid theory as well as in solid-state-physics. Combining past experience into this one project, together with the unique research environment at Cambridge, will train him in an important area crossing the disciplines of liquid physics, chemistry and materials science. Links with industry / industrial relevance (22) No direct collaboration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Wavefront shaping system for nonlinear fiber-based microscopy and endoscopy' to be submitted under Horizon 2020.

assistant: **Abstract**

The WAVESCOPE project is about exploiting a novel optical concept recently introduced by the PI in the domain of medical imaging.  This concept deals with the frontier research topic in the photonics, i.e.  the self-control of the spatial quality of optical beams in multimode nonlinear optical fibers.  The WAVESCOPE technology is poised to enable a breakthrough in the clinical domain, providing for the first time ever the stable delivery of high power and strongly focused optical beams with multimode optical fibers into the demanding domain of intraoperative imaging. In the state-of-the-art multimode nonlinear optical devices, propagation in multimode fibers is hampered by randomization of light beams, leading to beam scrambling after short lengths of fiber. This makes the use of multimode fibers unviable for real-time imaging, because of the necessary lengthy pre- and post-processing of the optical signal. Our approach is to exploit the intensity dependent refractive index of fibers to recover the spatial beam quality of a multimode wave. In the project we shall develop a new multimode fiber based device for scanning 3D samples with micrometer resolution by using ultrashort high peak power optical pulses, whereby fiber nonlinearity provides an environmentally robust compensation of temporal and spatial dispersion, thus preventing information spreading in time domain, and beam quality loss in the spatial domain. WAVESCOPE technology has applications in many industry fields: here we will demonstrate the proof-of-principle generation of high-resolution optical images in optical microscopy/endoscopy, thereby resolving an uncovered need on the introduction of the intraoperative pathologic assessment in oncology through the in-situ optical biopsy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of spiral heat exchanger/condenser' (1994-1998).

assistant: **Innovation**

In food and pharmaceutical industries spiralheatexchangers t condensers in the following called spiral have been used during many years for heatexchanging and condensing purposes when there is a need of favourable relations between heat transfer area and total volume see App no I. The spiral, with its benefits of long thermal length, compact small size, combination of a high flow and large heat transfer area, is especially suitable for sensitive products as e g flavourings, fragrances and proteins. :In t'ood industries it is used e. g. to condense water vapour at pasteurisation of milk and in pharmaceutical industries it is used when you condense solvents. The main problems with existing techniques to produce spirals are that it is not possible to increase the working pressure from 7 bar to 20 36 bar as it then leaks or breaks off \Vith a spiral of this low cost type which can withstand a working pressure of 36 bar the potential would be very large. The need for new techniques of heatexchanging / condensing have increased considerably as: treons are/will be prohibited in one way or another. energy has become more expensive. the requirements of the authorities have been stricter in t`ood and pharmaceutical processing. better use of energy due to less environmental impact The core group of this project is developing a low cost spiral, which will be able to withstand a pressure of 36 bar. J'hereby the group will innovate a product, which will in many applications fulfl the above mentioned needs. The new product is based on the same principles as existing spirals with a working pressure of 7 bar. However, in the developing work has arisen some technical problems regarding welding and rolling of the ductplates' which impede the development. This RTD project is started to inc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Transcription factor binding as a function of chromatin' to be submitted under Horizon 2020.

assistant: **Abstract**

How the genomic blueprint of an organism is translated into cellular phenotype is a fundamental question in modern biology. The instructions need to be specifically regulated for cells to function. The regulation of the readout of this information is not entirely written in the DNA sequence but also requires epigenetic directives like DNA and histone modifications.The maintenance of cellular states as well as their controlled differentiation requires the establishment of correct transcriptional patterns. Binding of specific transcription factors (TFs) to promoter and cis-regulatory regions is the key factor in regulating gene activity. This binding occurs in the context of chromatin, where nucleosomes and their modification states are thought to limit DNA access. This might in part account for why most TFs only occupy a minor fraction of their preferred sequence motifs. Moreover, chromatin sensitivity can create hierarchies between TFs since sensitive factors might rely on “pioneer” factors to establish a state of open chromatin. Despite its general relevance these models remain speculative due to limited understanding of the actual sensitivity of individual TFs to the local chromatin state.To narrow this gap in our knowledge I will establish a system to locally manipulate chromatin in vivo and measure the resulting effect on binding of individual TFs at a defined chromosomal site. By systematic variation of nucleosome positioning and epigenetic modifications and its impact on TF occupancy this project aims to generate novel insight into the fundamental principles that regulate transcription output.