RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enabling mass market adoption of SOFC fuel cell systems', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Elcogen’s mission is to be instrumental in realising the potential for distributed power generation from deploying SOFCs, the most efficient fuel cells when it comes to converting fuel to power and heat (CHP). However, there are two main obstacles to successful mass commercialisation: high manufacturing cost and insufficient life-time.Elcogen's SOFCs have best-in-class electrical efficiency of 74%, their lower operating temperature allows lower cost (up to 76%) fuel cell systems to be produced by CHP system manufacturers. They are fully validated for standard manufacturing techniques, are fully tested by customers and approved as the best performing.  Over the last 5 years Elcogen has developed the market for CHP (combined heat and power) and has now received purchase commitments from several customers. It has signed agreements with three key CHP Sumitomo Precision Products and LOI’s from SolidPower (Italy) and Convion (Finland). They are now waiting for large volume deliveries from Elcogen. Manufacturing scale up is a top priority now. Elcogen needs to plan the manufacturing plant scale-up with initial capacity of 2m cells p.a., envisaging revenues of €57m and EBITDA of €36m in 2023. The feasibility of the deployment of standard manufacturing equipment has been established during a Phase 1 study. It will be possible to reduce cell manufacturing cost by nearly 90% to €5 by 2021, compared with €40 for the current 2nd generation.Elcogen will deploy a cost-effective method for mass production of SOFCs, cutting fuel cell system costs by 65% compared with current system costs. This will open the path to widespread adoption of stationary power generation, unlocking a €25bn+ market for fuel cell systems, of which ~ 1/3rd will be for SOFC unit cells. The ramp-up of sales volume
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Synergistic modeling of gene-brain couplings with applications in affective neuroscience' (SYNEURGY) under Seventh Framework.

assistant: **Objectives**

Exploiting cross-modal integration for enhanced power and sensitivity, the recently emerged field of imaging genomics is at the frontline of available tools for identifying genes which influence the neurobiology of human behavior and psychiatric illness. Computational approaches are not, however, up to par with the complexity of the disparate data: there is an urgent need for integrative predictive modeling to overcome the interdisciplinary fragmentation between genomics and neuroimaging to harvest the full potential of the data. The methodological objective of this project is therefore to develop and implement integrative cross-modal algorithms for synergistic modeling of human genetic effects on brain responses patterns. To this end, the project will use tools from machine learning which allow powerful, multivariate, generic, data-driven, general purpose predictive modeling. Application side, the project will target the neurobiology of affective behavior and disorders through modeling gene-brain correlates in a population of individuals carrying a mutation resulting in atypical sense of affective touch and insensitivity to pain. Employing a cross-modal, multi-disciplinary approach, integrating genomics, neuroimaging and engineering at the frontier of neuroscience research, the project enables holistic modeling of genetic correlates of human behavior and psychiatric conditions revealing new therapeutic avenues. The project embodies the work program by providing excellent international, multi-disciplinary, cross-modal academic training, establishing a solid yet dynamic basis for a prolific long-term scientific career for the Fellow. The project will increase the attractiveness of the ERA through promoting the world-leading Swedish neurobiology research and facilitate mu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Clustering converging Tech Transfer Projects and innovative SMEs across 10 regions' (2002-2006).

assistant: **Innovation**

Tech SME Partnering project is to provide critical tools for 2 target groups in 11 Regions: 200 selected technology transfer (TT) projects presented by over 100 TT officers of Public Research Organisations (PROs), and; 200 innovative SMEs seeking to widen their resource base. The project will allow the 11 Regions to cluster these TT projects around the 200 SMEs.This will be done in a 2-year programme by:1. better defining the 200 TT projects together with the 200 experts and dynamic innovative SMEs in 11 Partnering Academies, or 1 in each Region;2. clustering the 200 TT projects and SMEs across the Regions into 6 specialised Clustering Fora (by sector) to facilitate partnerships;3. publish electronically the profiles and partnering requests of the TT projects and SMEs in an e-catalogue on the project portal to facilitate partnering and solicit interest from over 400 corporate and VC investors and partners.The project will lead to value and job creation: 40 TT projects or SMEs in discussion with investors, and; 60 TT projects or SMEs in discussion with research or business partners. There are 6 main and 4 smaller Regions participating each represented by a public or private body with a mandate (incl. a support letter for private bodies): Flanders, Stockholm area, UK NorthWest, Minho and Centre Portugal and Valencia, Rhine Alpes, and; Cyprus, Central Macedonia, Madeira and Great Plains Hungary (Szeged).The project is driven by 3 leading European organisations bringing unparalleled expertise: Europe Unlimited with a track record in coaching start-ups at the Gate2Growth Venture Academies and arranging investment fora, in cooperation with the IST and LSH programmes, ProTon Europe representing the majority of TT offices of PROs in Europe promoting tech transfer best practice,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Deep Learning for Automated Quantification of Radiographic Tumor Phenotypes'.

assistant: **Innovation**

Artificial Intelligence (AI), deep-learning in particular, is propelling the field of radiology forward at a rapid pace. In oncology, AI can characterize the radiomic phenotype of the entire tumor and provide a non-invasive window into the internal growth patterns of a cancer lesion. This is especially important for patients treated with immunotherapy as, despite the remarkable success of these novel therapies, the clinical benefit remains limited to a subset. As immunotherapy is expensive and could bring unnecessary toxicity there is a direct need to identify beneficial patients, but this remains difficult in clinical practice today. Radiomic biomarkers could address this, as, unlike biopsies that only represent a sample within the tumor, radiomics can depict a full picture of each cancer lesion with a single non-invasive examination. Previous work found significant connections between radiomic data, molecular pathways, and clinical outcomes. However, a direct link between radiomics and immunotherapy response has not yet been established.  This project will address this problem by analyzing unique multicentre clinical data, including non-invasive imaging, clinical outcomes, and extensive biologic characterization of patients with lung or melanoma cancer. Specifically, I will develop deep-learning radiomic biomarkers to predict immunotherapy response using baseline (WP1) and follow-up imaging (WP2). I will also investigate if radiomics can characterize underlying biological factors, and, in turn, can be used to improve response predictions (WP3). Successful completion of this proposal will demonstrate the potential of radiomics to help physicians in selecting patients who will likely benefit from immunotherapy, while sparing this expensive and potentially toxic treatmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Adaptive functions of visual systems'.

assistant: **Innovation**

The processing of visual information allows humans, animals, and computer-vision based machines to navigate the world. All visual systems face common challenges when the world rapidly changes. Such changes are often generated by an animal’s own movement. Self-motion for example causes fast changes in illumination and generates global motion patterns on the eye, due to the movement of the world relative to the observer. Diverse visual systems face these common challenges but must also deal with important differences. First, animals experience different environments. Second, animals show different types of behavior, such as walking or flying, and behavior will alter the visual cues that the animal encounters. The goal of AdaptiveVision is to first understand common principles of visual system function, and to then work out how diverse visual systems adapt to specific environmental and behavioral constraints. To achieve this, AdaptiveVision will study two essential visual computations, the robust estimation of contrast in dynamically changing environments, and the encoding of global motion cues generated by self-motion. For both topics, AdaptiveVision will follow a common approach: We will first study the mechanisms of visual computation in D.melanogaster. This model organism allows to identify molecular, biophysical, and circuit mechanisms of visual system function and link these back to behavior, ensuring a comprehensive understanding of visual computation. Second, a comparative approach will answer how diverse visual systems adapt to the individual constraints brought about by the environments and by the animal’s own behavior. Developing different Drosophila species as genetic models or applying transcriptomic techniques in different Diptera will allow us to obtain mole
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Conceptualising Processes of Monumental Architectural Creation in the Eastern Mediterranean Bronze Age'.

assistant: **Concept**

DAEDALOS aims to challenge the predominant metanarrative that uniformly sees monuments as an attribute of centralised, hierarchical political economies and top-down power structures, a view that exerts a strong influence on our understanding of the organisation of Bronze Age Eastern Mediterranean societies. In the 2nd mill. BCE, Mainland Greece, Western Anatolia and the islands of Crete, Cyprus and the Cyclades witness a growing architectural elaboration. Impressive ‘palatial’ monuments are built, which are often interpreted as the seat of rulers exerting centralised control over the population. The surmised political power necessary for the mobilisation and management of the human and material resources invested in monumental construction is taken as further evidence for the leading function of these edifices, and for the position of their commissioners at the top of hierarchical socio-political systems. Taking into consideration the ability for human groups with no centralised leadership to efficiently manage and control resources, DAEDALOS questions the preconceived conflation of monumental architecture and centralised hierarchical power. To assess this, the project will analyse integration and segmentation patterns in 2nd mill. BCE monumental building projects of the Aegean and Cyprus, and investigate the organisational centralisation of the societies that managed the labour and material resources invested in construction. Based on the architectural study of monuments distributed over 35 sites and their examination through new, specially devised analytical parameters, DAEDALOS will explore the possibility for grassroots, bottom-up building processes and their impact on architectural creation. By doing so, the project aims to trigger a paradigm shift in the ways we a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Body-Politics: Personhood, Sexuality, and Death in the Iron and Viking Ages' in the context of a Horizon 2020 call.

assistant: **Objectives**

The overall objective of BODY-POLITICS is to provide an original and creative analysis of body-politics and personhood in first millennium Northern Europe. It is the first large-scale research project that seeks to understand political development through the battleground of the body and through the construction of the person in the Scandinavian Iron and Viking Ages. BODY-POLITICS will break new ground in combining cutting-edge natural science methods (aDNA, isotope analyses, osteobiography) with core social and philosophical concerns. The project will moreover provide problematizing research on challenging topics: sexual assault, subalterns as non-persons, and ritual violence, in an era that is frequently romanticized and has never seen more popular attention.Through an interdisciplinary research programme, the body will be centred as a political medium targeting three core themes: personhood, sexuality, and death. To operationalize the overall objective, BODY-POLITICS will conduct ground-breaking analyses of five interlinked datasets: 1) a never-before studied database of bodies deposited in settlements in the first millennium; 2) an in-depth study of infants, who are situated between sentient object and full social persons; 3) a novel dataset of sexuality and sexual violence in texts and things; 4) body imagery as it exposes body concepts; and 5) textual evidence of distinctions in personhood. In combination, these analyses provide glimpses of radically diverse concepts of the body: of ‘proper’ death, of sexuality as an instrument of violence and medium for power, of complex interplay between bodies and body imagery, and of blurring between bodies as social subjects and meaningful objects. Ultimately, the question of who could be a person in Iron and Viking Age Scand
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Opportunity Ecosystems Bridging the Gender Gap' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Bridging the gender gap, in its mature phase, means moving through collaboration in scientific sectors towards innovation in business sectors. Shemakes.eu blends the approaches of two leading innovation ecosystems – Fabricademy (https://textile-academy.org/) and TCBL (https://tcbl.eu/) - within the textiles and clothing sector and acts to promote, highlight and celebrate the leading role of women in innovation, with the goal of permanently re-shaping the opportunity structures of at least 16 European Member States and Associated Countries.To carry out this goal, shemakes.eu develops an integrated innovation ecosystem promoting gender parity along three strategic axes:- Learning Paths, modelled on the Fabricademy curricula, engage girls and women innovators belonging to three age groups.- Innovation Services, based on the TCBL Lab Service model, engage local communities and businesses in collaborative innovation activities as well as carrying out networked multi-Lab innovation projects and validating new business concepts.- Reputation Management promotes different types of role models within the community of the girls and women leading the way in the sector’s transformation.These activities are accompanied by four transversal WPs – Opportunity Ecosystem, Evaluation and Impact Assessment, Communication and Dissemination, and Project Management - that ensure their coherence in working towards the overall objectives.Shemakes.eu is a two-year initiative with a consortium of 10 partners in 7 countries, led by the service company of the TCBL network; its activities expand from a first set of 6 core Labs to incorporate 12 ‘transfer’ Labs in a second phase of implementation. Sustainability is ensured by incorporation of the new learning and service modules into the two pre-exist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular signals for synaptic pruning by microglia' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

While emerging body of evidence implicates microglia in synaptic pruning and indicates the role of complement system in mediating phagocytosis of synaptic elements by surrounding microglia, no neuronal signals that label synapses according to their activity and maturity have been identified yet. Here we propose to develop an organotypic hippocampal slice culture system to investigate synaptic pruning during development, and to use it to identify candidate molecular tags that mediate discrimination between weak and strong synapses during circuit maturation. We will test two candidate molecules: ""don’t-eat-me"" signal sialic acid and ""eat-me"" signal phosphatidylserine. Using time-lapse spinning disc microscopy of live organotypic slices, pharmacological manipulations and optogenetics we will observe local neural activity-dependent dynamics of desialyation and phosphatidylserine exposure on synapses. Organotypic hippocampal cultures prepared from genetically modified animals lacking sialidase or phospholipid scramblase as well as their chimeras with wild-type animals will help to validate the role of candidate phagocytic signals in synaptic pruning and to determine whether these signaling molecules are cell-autonomous or disturb the system as a whole. Since aberrant or impaired synaptic pruning is hypothesized to be involved in the pathology of various neurodevelopmental disorders, such as autism and Rett Syndrome, as well a mental illness, such as schizophrenia, uncovering the mechanisms that mediate circuit formation and refinement are crucial for understanding these disorders and to develop new approaches to their treatment. The research proposed here will provide invaluable insight into the cellular and molecular mechanisms by which microglia refine circuits and con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Identifying the role of injury-associated cellular reprogramming in the early oncogenic transformation of human colonic epithelium' (PreCODE) targeting Horizon Europe.

assistant: **Abstract**

Colorectal cancer represents a major public health problem being the second leading cause of cancer-related deaths worldwide. The treatment management of the already developed disease is however often time-consuming, expensive and rarely 100% effective. Therefore, the goal should be to start diagnosing and managing the diseased state as early as possible when cancer is still curable. The early cellular transformation events remain poorly understood as cancer-associated mutations have been found to be surprisingly prevalent in seemingly healthy tissues, suggesting the requirement for a potent trigger mechanism. With this project, I aim to study the early colonic transformation via a completely unique hypothesis and approach. My strategy is built on the emerging new “injury-triggered fetal-like state” concept guided by my host lab and the hypothesis that oncogenic mutations require transcriptional reprogramming to a more susceptible fetal-like state to trigger transformation. This hypothesis relies on the fact that the fetal-like state is observed during injury and also in subsets of tumors indicating that cellular reprogramming could play a prominent role in promoting oncogenic transformation. As a primary model system, I will make use of my extensive experience with cancer modeling via 3D human-derived organoids and CRISPR technology, and elevate these techniques by the state-of-the-art expertise available at the host lab and/or institution, such as in vivo orthotopic cell transplantation, epigenetic profiling, advanced CRISPR-screening methodology and clinical collaboration. By bringing together such intelligent methodology, I will be able to effectively investigate the role of injury-induced cellular reprogramming in the transformation of human colonic epithelium. The