RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Protecting Small and Medium-sized Enterprises digital technology through an innovative cyber-SECurity framework'.

assistant: **Innovation**

Small and Medium size Enterprises (SMEs) are an important driver for innovation and growth in the EU. SMEs also stand to gain the most from innovative technology, because it is complicated and costly for them to set-up and run ICT in the traditional way. Taking into account cyber-security, SMEs do not always understand all the risks and business consequences for the development of technologies without the adequate level of protection against cybercrime.The European Union Agency for Network and Information Security (ENISA) declares on the “Information security and privacy Standards for SMEs” study of 2016 that, despite rising concerns on information security risks, the level of SMEs information security and privacy Standard adoption is relatively low.SMESEC consortium is proposing to develop a cost-effective framework composed of specific cyber-security tool-kit to support SMEs in managing network information security risks and threats, as well as in identifying opportunities for implementing secure innovative technology in the digital market; for this consortium, it is important that SMEs do not only look at cyber-security as an obstacle, but also they understand the business opportunity beyond it.In this scenario, an international group of experts proposes SMESEC as a response to the cyber-security challenges for business companies with a limited background on cyber-security and a restricted budget. The SMESEC project will be developed in 36 months by a competitive consortium of 12 partners from 7 countries, which corresponds to a well-balanced structure, involving big companies, SMEs, research centres and universities. Despite the great diversity of entities within the proposal, SMESEC is an industry-oriented project, since the private companies will cover more than 7
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Managing water scarcity: Intelligent tools and cooperative strategIes' (MAI-TAI), addressing dissemination and exploitation.

assistant: **Impact**

MAI-TAI deals with integrated water resources management. It is designed as a 3 year coordination action of leading research and innovation operators, aiming at developing a coherent set of innovative, relevant and cooperative policy options and management strategies. Regionally it works with partners from China and India, and the work will focus around one river basin in each country.The proposal features the following core coordination activities:1. Enabling a dialogue between researchers and practitioners promoting state of the art and indigenous technologies & practices: The consortium believes that modern systems alone are not capable of solving the water needs of the people in many developing countries, and there is a strong need of generating innovative options through cross fertilization between both worlds". This "cross-fertilization" will be enabled by methods and rich experiences of user innovations research.2. Based on (1), innovative policy options and management strategies will be compiled. Then, a multi-stakeholder interaction in order to evaluate these options and strategies will be carried out, supported by intelligent knowledge management tools: In the presence of a variety of actors (institutions, organisations, individuals) each with specific forms of knowledge with respect to scale, topic, reasoning processes, and a large number of information expected to be generated through the multi-stakeholder interaction, the issue of learning and knowledge management is of paramount importance.A strong impact of the coordination action is ensured by a highly inter- and transdisciplinary team, (in total 13 project partners) encompassing internationally reputable scientific institutions as well as strong governmental partners and NGOs. The latter two will consid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Oxidative stress in endothelial cells' under Sixth Framework.

assistant: **Concept**

Reactive oxygen species (ROS) have been recently qualified as intracellular second messengers essential to many growth factors signalling. However, excess of ROS production by the newly discovered integral membrane NADPH oxidases (NOXs) results in or accompanies a large spectrum of life-threatening human diseases including cancer, diabetes, vascular diseases, neurodegeneration and aging. Although NOXs are the main ROS producing enzyme in vascular cells where they are involved angiogenesis and in the atherosclerosis pathology (through endothelial senescence), a lot is unknown about the pathways regulating NOX activity in endothelial cells.Therefore, I used the yeast two-hybrid system to identify TEM8 as a novel protein interacting with NOXO1, an essential adaptor and regulatory protein of NOXs. TEM8 is expressed in the vessels of tumours and early developing mouse embryos. I propose a multidisciplinary approach using specific ROS probes, shRNA, live imaging and physiological readouts to functionally character ize the TEM8/NOXO1 interaction in what could be a new angiogenic pathway. Furthermore, I will use the new and innovative yeast membrane split-ubiquitin system to identify proteins interacting with (and regulating) NOX1 and NOX4, the membrane proteins within the NOX complex. In contrast to the traditional yeast-two hybrid system, the split-ubiquitin system allows for the identification of protein interacting with transmembrane proteins. Moreover, the split-ubiquitin system will be modified to allow co-expression in yeast of NOX1 (or NOX4) with p22phox the essential component of the complex.Then, I will identify proteins interacting with the NOX/p22phox complex. This is especially relevant since known NOXs effectors, NOXA1 and NOXO1, interact preferentially with the c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Plasma membrane probes for photo-controlled release of signaling molecules' (MemCage) targeting Horizon Europe.

assistant: **Abstract**

The cell plasma membrane (PM) of eukaryotic cells is a highly dynamic structure, which plays important role in diverse biological processes such as cellular uptake, neural communication, muscle contraction, and cell trafficking and signaling. The PMs are also responsible for communication between cells, especially between neurons. In particular, the exocytosis process leads to liberation of neurotransmitters and neuromodulators. On the other hand, it is a platform for receptors that convert the recognition of neuroactive molecules into ion flux and/or action potential. Therefore, to modulate and monitor the activity of neurons, an attractive approach is to design molecular tools that target cell PMs. In this project, we will combine PM-targeting anchors with photoactive fluorescent cages capable to photo-release signaling molecules. The obtained chemical tools (MemCages) will be applied for 1) imaging the neuronal organization and 2) photo-controlled activation of neurons and brain of mice by photo-uncaging of signaling molecules close to PM. The work is composed of 3 steps. First is synthesis of MemCages for dopamine and glutamate and their validation in solvents and model lipid membranes. Second is application of MemCages in cellular systems, which includes imaging and photo-stimulation of model cancer cell lines and neurons. The first step will be in vivo validation of MemCages, which will be done during the secondment. The applicant and the host laboratory plan extensive two-way knowledge transfer: the applicant will gain knowledge and expertise in membrane probe design, bioimaging in model membranes, cells and animals, whereas he will provide his expertise on design and characterization of molecular photocages for signaling molecules. The successful utility of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Stability and dynamics at different spatial scales: From physiology to Alzheimer's degeneration'.

assistant: **Objectives**

How neuronal circuits maintain the balance between stability and plasticity in a constantly changing environment remains one of the most fundamental questions in neuroscience. Empirical and theoretical studies suggest that homeostatic negative feedback mechanisms operate to stabilize the function of a system at a set point level of activity. While extensive research uncovered diverse homeostatic mechanisms that maintain activity of neural circuits at extended timescales, several key questions remain open. First, what are the basic principles and the molecular machinery underlying invariant population dynamics of neural circuits, composed from intrinsically unstable activity patterns of individual neurons? Second, is homeostatic regulation compromised in Alzheimer's disease (AD) and do homeostatic failures lead to aberrant brain activity and memory decline, the overlapping phenotypes of AD and many other distinct neurodegenerative disorders? And finally, how do homeostatic systems operate in vivo under experience-dependent changes in firing rates and patterns? To target these questions, we have developed an integrative approach to study the relationships between ongoing spiking activity of individual neurons and neuronal populations, signaling processes at the level of single synapses and neuronal meta-plasticity. We will focus on hippocampal circuitry and combine ex vivo electrophysiology, single- and two-photon excitation imaging, time-resolved fluorescence microscopy and molecular biology, together with longitudinal monitoring of activity from large populations of hippocampal neurons in freely behaving mice. Utilizing these state-of-the-art approaches, we will determine how firing stability is maintained at different spatial scales and what are the mechanisms leading
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Absorbable and wearable keratin-based nanofibers for wound healing and skin reconstruction' (SkinKer).

assistant: **Innovation**

A lot of efforts is being put lately on the development of active wound care products. The use of keratin in dressings for dermal injury (such as a burn injury) could support skin reconstruction and would healing. However, so far this has not been possible due to: 1) the low quality of the hydrolyzed keratin extracted so far that make it useless and ineffective in biomedical formulations; 2) the hydrophobic solvents used make it impossible to mix the keratin in water-based formulations and to produce nanofibers through electrospinning.KerLine has a ready-to-patent proprietary method to fabricate nanofibrous dressings for biomedical applications through electrospinning technique starting from hydrosoluble keratin and active ingredients in water solution (SkinKer dressings). This has been so far never possible because water insoluble keratin cannot be electrospun. Kerline technology offer an outstanding technological and manufacturing advantage as respect to competitors as it allows to fabricate safer, cost-effective and advantageous SkinKer dressings. In addition, SkinKer dressings offer: i) a complete coverage of the injured tissue adhesion; ii) a protection against infections and dehydration with air permeation and iii) the delivery of drugs (e.g. antioxidant, anti-inflammatory and antimicrobial agents) to the wound.KerLine aims to produce electrospun SkinKer dressings for the biomedical sectors and sell customized products by reaching B2B licenses and commercial agreements with companies operating in the field of biomedical devices for skin reconstruction and wound healing. Kerline aims to become a market leader in natural biomaterials used for biomedical applications by substituting inert biomaterials with the natural and multifunctional properties of hydrosoluble ke
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Nanostructured Magnetic Materials for Nanospintronics'.

assistant: **Concept**

We are proposing a Collaborative Project, NAMASTE, on nanostructured dilute magnetic semiconductor and metal materials. The key ideas are to control and manipulate the nanoscale properties of magnetic materials by local strain and electric fields making possible new types of magneto-electronic and spintronic devices. This is a co-ordinated programme of theoretical, experimental and technological research by a consortium of European academic and industrial research groups, each of which is internationally leading in the complementary, multidisciplinary research fields essential to the project delivery. The proposal builds on recent advances in the state-of-the-art by the consortium members and is based on the design of materials whose specific nanostructure yields the required tailored properties. NAMASTE should significantly advance the understanding of nanostructured magnetic materials and magnetic phenomena at the nanoscale. The project has a high probability of major medium and long term impact on many aspects of spintronics, magnetic data storage and processing, and magnetic sensors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MARINE BIODIVERSITY AND ECOSYSTEM FUNCTIONING', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Knowledge on marine biodiversity in Europe is fragmented within and between disciplines. The approach to understanding the effects of increased anthropogenic pressure on marine biodiversity has hitherto been ad hoard local. In particular, to understand how marine ecosystems will adapt to climate change, we need addressing especially the long-term and large-scale changes in marine biodiversity. This requires an entirely new research framework.The creation of the network of excellence MARBEF (Marine Biodiversity and Ecosystem Functioning) aims at integrating research efforts by forming a dedicated group of marine scientists and institutes and creating a virtual European institute with a long-term research programme and dedicated links with industry and the public at large. This involves besides coordination of research the training, exchange and outreach activities in several relevant fields of science, including marine ecology and biogeochemistry, fisheries biology, taxonomy and socio-economic sciences. Better integration of research is also required to support the legal obligations of the EU and its member states and associated states for the Convention for Biological Diversity, Theo SPAR and Barcelona conventions as well as several EU directives (Bird Directive, Habitat Directive, Water Framework Directive). Society needs this information because a large and growing number of industries depend on the sustainable use and exploitation of marine biodiversity. This includes tourism, fisheries and aquaculture but also new industries that explore and commercialise marine genetic and chemical products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European methanol powered fuel cell CHP' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In the EMPOWER project a methanol fuelled 5 kWe mini-CHP system based on HTPEMFC technology is developed, manufactured and validated in a relevant environment. The system efficiency over 50% (DC, LHV) is achieved with novel ideas of thermal integration with a two-stage reformer setup and by using thermoelectric generators (TEG), utilising the high temperature heat of HTPEMFC stack.An aqueous phase reformer (APR) for methanol pre-reforming is applied for the first time in a commercial scale HTPEMFC system. The use of APR and its thermal integration in the FC system enables efficient utilisation of the stack waste heat and enables reformer efficiency approaching 95%. The best available catalysts will be screened and adapted for the reformer, both for the APR and for the 2nd stage reformer, which employs commercialised reformer technology from project partner Catator and recently developed methanol-reforming catalyst from partner University of Porto.The system efficiency is further improved by increasing the fuel utilization to above 95% in the HTPEMFC stack. This is enabled by improving anode gas flow distribution in the cells as well as improving the stack end plates. The new end plate design will also enable stack pressurising and improving stack efficiency over 55 %. The improvements in the HTPEM system design for mini-CHP use are validated in relevant environment, coupled to the heating and power system of a detached house, so that reliable data of the operation and stability can be generated. The accelerated test will be carried out for a period of 6 months and for at least 2,000 h of operation.  Lastly, the project includes planning for scaling both the reformer solution and CHP system to 50-100 kWe size, including the addition of expanders. The technical work is co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploring nonclassical states of center-of-mass mechanical motion with superconducting magneto- and levitomechanics' under Horizon Europe.

assistant: **Concept**

SuperMeQ addresses three basic science goals in quantum technologies, targeting to gain new insights into quantum control  over the center-of-mass motion of mechanical resonators: (i) We will push to the limits of decoherence mechanisms of massive objects, (ii) we will maximize the vacuum coupling of the center-of-mass motion of a mechanical resonator to a quantum system, and (iii) we will generate useful nonclassical states such as squeezed states or states with a negative Wigner function, which have direct relevance for quantum-enhanced force and inertial sensing. Our project follows a unique approach by realizing two complementary experimental platforms that are tailored to our goals and that are mutually beneficial through parallel development: (a) magnetically levitated superconducting microparticles that access a mass regime spanning more than seven orders of magnitude between picogram and sub-milligram masses, and that are expected to exhibit ultra-low mechanical decoherence, and (b) integrated clamped magnetic or superconducting mechanical resonators that are expected to reach strong vacuum coupling rates, two orders of magnitude larger than the state-of-the-art. Key in each of these approaches is that we will couple both types of mechanical resonator inductively to superconducting quantum circuits, which allow for full quantum control over the center-of-mass degree of freedom of the mechanical resonators. Our project results will lead to a breakthrough in the development and growth of novel quantum sensing technologies and give new insights into foundational aspects of quantum physics.


**Keywords:** decoherence, massive quantum systems, superconducting quantum circuits, nanomechanical resonators, optomechanics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A biorefinery for upcycling coffee waste into sustainable, healthy, high-value ingredients' (KB-BIOREFINERY) targeting Horizon Europe.

assistant: **Abstract**

Kaffe Bueno has developed an innovative model for upcycling coffee waste into high-value ingredients. Coffee is highly bioactive with huge reservoirs of lipids, melanoidins and phenols. Yet we currently use just 1% of its potential. Discarded coffee waste ends up in landfill, producing methane and CO2, or is reused as biofuel or compost. Kaffe Bueno transforms this wasted resource into a business opportunity. We produce high quality coffee oil, melanoidins and lignin/phenols as sustainable, natural active ingredients, sold B2B to manufacturers of cosmetics and personal care products, helping Denmark and the EU meet their targets for carbon reduction by 2030. We aim to valorise 100% of our coffee waste feedstock. In this project, Kaffe Bueno will build and optimise a demo biorefinery with the capacity to process 200 tons of coffee waste /year, using our efficient, proprietary process, then use equity to expand this plant’s capacity to 1200 tons and invest in R & D for new applications.


**Keywords:** Coffee,Active Ingredients for cosmetics,Nutraceuticals,Cosmetics,Functional food,Bio-refinery,Coffee waste upcyling,Natural products