RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular organization and dynamics of synapse diversity:  novel genetic, imaging and computational approaches' (SYNNOVATE) under Horizon 2020.

assistant: **Objectives**

Synapses are a hallmark of the brain, showing remarkable anatomical and molecular complexity, and central to the aetiology and progression of hundreds of brain diseases. The vertebrate brain has a vast potential synapse diversity arising from the differential distribution of combinations of proteins into individual synapses. This has led to the recognition that “synaptome mapping” needs to be developed where the expression level of individual proteins is robustly measured in individual synapses across the whole brain.  We developed a novel and unique ‘synaptome discovery and imaging platform’ that links the molecular organisation of synapses with the spatial and temporal anatomical diversity of individual synapses and charts molecular synaptome maps across the brain. This platform enables routine and rapid quantification of genetically encoded molecular markers, with multiple functionalities, in almost a billion synapses in hundreds of brain regions of the mouse and generates statistically robust synapse catalogues and molecular maps of the brain. We have uncovered remarkable new neuroanatomical features and revealed a synaptic molecular architecture at the systems-wide scale. We have discovered this architecture is radically reorganised by mutations that cause schizophrenia, intellectual disability and autism. We have also shown these new methods can label activity-dependent reorganisation of single synapses at a whole brain scale, enabling the tracing of synaptic memory engrams. Our goals are to understand how synaptome maps develop and are reorganized by mutations causing cognitive disorders; examine experience-dependent map plasticity during development, following learning and electrophysiological stimulation in normal animals and those carrying cognitive disorder m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Cosmochemical Exploration of the first two Million Years of the Solar System'.

assistant: **Objectives**

One of the major outcomes of recent studies on the formation of the Solar System is the reconnaissance of the fundamental importance of processes which took place during the first 10 thousands to 2 or 3 millions years of the lifetime of the Sun and its accretion disk. Astrophysical observations in the optical to infrared wavelengths of circumstellar disks around young stars have shown the existence in the inner disk of high-temperature processing of the dust. X-ray observations of T-Tauri stars revealed that they exhibit X-ray flare enhancements by several orders of magnitude. The work we have performed over the last years on the isotopic analysis of either solar wind trapped in lunar soils or of Ca-, Al-rich inclusions and chondrules from primitive chondrites, has allowed us to link some of these astrophysical observations around young stars with processes, such as irradiation by energetic particles and UV light, which took place around the T-Tauri Sun.   The aim of this project is to make decisive progress in our understanding of the early solar system though the development of in situ high-precision isotopic measurements by ion microprobe in extra-terrestrial matter. The project will be focused on the exploration of the variations in the isotopic composition of O and Mg and in the concentration of short-lived radioactive nuclides, such as 26Al and 10Be, with half-lives shorter than 1.5 millions years. A special emphasis will be put on the search for nuclides with very short half-lives such as 32Si (650 years) and 14C (5730 years), nuclides which have never been discovered yet in meteorites. These new data will bring critical information on, for instance, the astrophysical context for the formation of the Sun and the first solids in the accretion disk, or the timing a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'NUclear reactions at RINGs'.

assistant: **Objectives**

Neutron-induced cross sections of short lived nuclei are key quantities in many domains, such as fundamental nuclear physics, astrophysics and applications in nuclear technology. However, the difficulties to produce and manipulate the necessary amounts of radioactive nuclei make the measurement of such cross sections with current techniques extremely difficult or even impossible. Surrogate reactions in inverse kinematics represent the most promising indirect approach to determine these cross sections: The excited nucleus of interest is produced by a different reaction than the neutron-induced reaction. The measured decay probabilities strongly constrain model parameters enabling accurate predictions of the desired neutron cross section. We propose to combine surrogate reactions with the unique possibilities at ion storage rings, which are high-precision tools to study nuclear reactions in inverse kinematics with radioactive ion beams. The advantages range from greatly improved beam properties over the absence of target contaminants and backings, and a strong reduction of the straggling, thanks to the use of pure, windowless and ultra-thin targets. However, the demanding vacuum conditions of storage rings put severe constraints on the detection setup. In addition, it is necessary to validate this completely new methodology by comparing first results with good-quality data measured in direct kinematics. Still, there is a lack of direct-kinematics data that can be used as benchmark.We propose to perform simulations to define the set-up for the first surrogate-reaction measurements at the storage rings of the GSI facility. We will also investigate innovative solutions to overcome the vacuum issues like the use of solar cells. Finally, we will measure the 208Pb(d,d’) reactio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Micrometer scale patterning of protein and DNA chips' (MICROPROTEIN).

assistant: **Concept**

The objective of the present proposal is to develop techniques and processes for micrometer scale patterning of protein and DNA arrays for the next biochip generation. Three different techniques will be developed and tested that are largely bio molecule and substrate independent:a. The development of biocompatible photo patterning methodologies including polymeric photo resists with adequate characteristics,b. The development of processes and materials compatible with the use of laser ablation for micropatterningc. The development of methods and materials for patterning by low-voltage electrowetting micro spotting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Integration of wind turbines into electricity supply networks with limited power transportation capacity'.

assistant: **Innovation**

Wind energy had a tremendous growth in European countries in the past years, and this will continue if policies do not change significantly. In areas with high installation densities large penetration of wind energy is likely to occur. This leads to a significant influence of wind energy generation on the whole network situation from low to high voltage grid levels: the power quality of wind turbines (WT's), the energy flows to local consumers and the control of WT's play an important role. The reliability of wind energy generation strongly depends on WT power quality and grid conditions. The prime aim of the project work, is to significantly improve the economical and technical situation of WT's connected to a grid by lowering connection costs or grid reinforcement costs and increasing use of existing grid capacities. Especially in networks with already high wind energy contribution and/or weak grid conditions the cost and technical situation can be improved significantly. The tools and results gained within this project will help utilities, developers and manufacturers in the following way. - Better use of existing grid capacities will be made due to the fact, that utilities will be enabled to use not worst case assumptions for grid distortion calculation but detailed tools, taking into account the specific power quality of WT's and the specific local grid situation. Thus the grid capacity can be used intensively, allowing higher installation capacities and reduction of grid connection costs. - The development of WT control strategies towards reduction of distortion and stabilisation of line voltage will help to stabilise and improve the network situation especially in weak, soft and isolated grid conditions. This will also help to improve reliability of power generat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ionisation-based detector of airborne bio-agents, viruses and toxins for fast-alert and identification' to be submitted under Seventh Framework.

assistant: **Abstract**

The malevolent use of Anthrax spores on civilians in late 2001 has shown the necessity to protect European citizens from criminal use of biological agents and viruses. Although these attacks had been punctual and crude, more sophisticated attacks on dozens or hundreds of injured or killed people are conceivable. When launching such an attack its success depends on concentrating a sufficient amount of pathogens in a defined area.Hence safeguarding a certain area regarding biological agents demands the detection of pathogenous bacteria, spores and viruses in various matrices (e.g. Anthrax in flour or sugar) or suspicious aerosols. This can only be accomplished by triggering a short-term alarm and its validation as well as the identification of the type of threat.Since most of the bio sensors available are laboratory bound or require special equipment which needs training as well as experience, new systems are needed.The concept of BIO-PROTECT is the development of a fast-alert, easy-to-use device to be applied for detection and identification of airborne bacteria, spores, viruses and toxins . Its technology is based on bioaerosol detection by fluorescence, scattering and background aerosol measurement followed by ionisation of air flow and analysis of the spectrum of relative speed of passage, which, in turns, enables identification of harmful biological agents.This device may also be used for controlling potential accidental release of bio-agents from biotechnology laboratories.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Self-Assembling, Self-Monitoring, Multi-Stimuli-Responsive Implants for the Minimally Invasive Treatment of Critical-Size Defects'.

assistant: **Innovation**

The treatment of critical-size defects—too large to heal naturally—is typically approached with invasive surgical procedures or external fixation devices, with the associated long rehabilitation times, emotional exhaustion, and high failure rates. This project aims at creating self-assembling implants capable of inducing tissue and bone regeneration in critical-size defects using minimally invasive procedures. The implants will feature a frame of superelastic and shape-morphing NiTi wovens, with the ability to fold for facilitating insertion and unfold after placement. The geometry of the NiTi structure will be custom-designed to meet the dimensions of the defects and define the healing volume. After inserting and unfolding the frame, the core of the implant will be filled with stimuli-responsive and anti-bacterial hydrogels, and self-assembling piezoresistive and electromagnetically functional structures for stimulation, sensing and monitoring. The implant will be completed with the incorporation of cells, spheroids and organoids to act as versatile cell sources and enable tissue regeneration. The project builds upon expertise from the host institution in additive manufacturing (AM) of NiTi employing laser powder bed fusion and from the candidate in the 3D and 4D printing of stimuli-responsive electroactive composites. It will contribute to the research line on materials for healthcare from the host institution and to its research program on advanced materials processing. The host institution will benefit from an expanded portfolio of materials and technologies, especially as regards the printing of piezoresistive and electromagnetically functional structures, while the candidate will expand his background on biomedical applications of AM and initiate a personal resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Development and application of remote sensing techniques and geographic information systems for designing environmentally sustainable land-use systems - ii)'.

assistant: **Innovation**

Research objectives and content The proposed project consists of a land evaluation assessment in the Ebro delta using remote sensing techniques and geographic information systems. The objective of the research is to identify and quantify the main factors limiting rice production as well as, an integrated environmental study of the landuse management alternatives. First of all, special emphasis was made on multitemporal appraisal of remote sensing data. During 1994, 1995 and 1996 strong efforts were made to model rice crop growth and development, to evaluate the geobiophysical factors limiting the optimal yield, and to establish the soil-plant relationships and reflectance. During the return grant. the thematic mapping pattern spatial analysis together with the rice production modeling will specify a landuse management optimization. Finally a geographical information system of the study area with all the data collected will be developed, where the environmental variables and their interrelations will be evaluated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'How the physical environment shapes the human brain' in the context of a Horizon Europe call.

assistant: **Objectives**

BrainScape constitutes a timely approach to study a widely unexplored aspect in the neurosciences, namely whether and how the physical environment that surrounds us day in, day out impacts our brain, well-being and mental health. BrainScape aims to spearhead the emerging field of Environmental Neuroscience and will make an impact by building a knowledge base for evidence-based urban planning to promote healthy living environments with significant practical implications. Given that our environment is undergoing rapid changes (urbanization, climate change), understanding how these changes may impact humanity is a crucial challenge of our time. First evidence suggests that long-term as well as day-to-day variations in exposure to solitary environmental factors (e.g. air pollution) may be relevant. The goal of BrainScape is twofold: (1) to identify the “active ingredients” of the environment by introducing a more holistic understanding of the environment, as a multi-layered complex phenomenon and (2) to gain insight into the pathways and mechanisms by which the environment affects the brain and mental health. To accomplish this, BrainScape will utilize existing large-scale cross-sectional and longitudinal neuroimaging data sets (UK Biobank, NAKO, HCHS, IMAGEN) to identify the most important features of the physical environment. These features will be at the core of prospective controlled studies, including a discordant monozygotic twin study. Here we will combine the assessment of objectively experienced (e.g., wearable sensors) and subjectively perceived environment with brain plasticity measured using 7 T MRI. The identification of the most influential environmental salutogenic features will inform a targeted intervention study and experiments in highly controlled lab env
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Anthropogenically induced changes in groundwater outflow and quality, and the functioning of Eastern African nearshore ecosystems' to be submitted under Fourth Framework.

assistant: **Abstract**

The key objective of the research project is: * To assess the significance of changing inputs of groundwater and the anthropogenic substances it contains for Eastern African nearshore ecosystems.* To meet the general objective of the project, three more specific objectives will be pursued, which are indicated below together with an outline of the project methodology:(1) To construct a model of groundwater flow along the Eastern African coast.(2) To elucidate differences in nearshore community structures and ecosystem functions in relation to groundwater outflow.(3) To elucidate the importance of groundwater as a vector of anthropogenic inputs into the coastal zone.Expected OutcomeThe project will contribute to the assessment of the significance of groundwater flow and contamination for tropical nearshore ecosystems, and on the vulnerability of these systems to changes in groundwater outflow. The programme will lead to the definition of a hierarchy in components and functions of the nearshore coastal ecosystems that are most sensitive to groundwater efflux. This information will help to delimit vulnerable coastal areas. The hydrological model developed in the project, moreover, will make it possible to assess the impact of various levels of disturbance on the groundwater flow, thereby improving the perspectives for sound management of the coastal environment.The key activities envisaged are:* Existing data on aquifers and the water balance in Eastern African coastal areas and hydrological field data will be collected, with the aim to construct a model of groundwater outflow that will allow a prediction of the response of the hydrological system to anthropogenic disturbances.* Community structures in nearshore habitats will be studied in relation to different levels of gr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Earth observation based flood risk information Management service' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The overall objective of the SIREN project is to define and specify an Earth observation based flood risk information service in order to bridge the gap between customers" and "EO data" for flood management (prevention, crisis and post-crisis). The design of such a user oriented service is justified by the interest expressed by customers (Civil Protection authorities, river basin authorities...) concerning the use of EO derived information in the domain of flood risk management but also by their difficulties to introduce this new technology in an operational context. The proposed service is organized in two main functions which are considered to be necessary to satisfy the needs expressed by end-users. The first is the "customer service", interface between the customer and the EO data provider. It allows the customer to submit queries and to receive the relevant information products. The second one is necessary to transform EO data into the high level thematic products required by these customers in relation to their prevention, crisis and post-crisis activities. The information system as well as the distributed architecture proposed in SIREN will be defined in the "spirit" of the CEO. Their complementarity and synergy with the CEO programme represent one of the main characteristics of this project. If some components of SIREN contribute to CEO programmes (User Support, Enabling Services), the service demonstrator implemented in this project will also take advantage of the services provided within the framework of the CEO, in particular to raise potential customers awareness about the interest of EO products in the field of flood risk management. Starting with the consolidation of users requirement (part of the needed information is coming from previous studies in which