RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Improving the optical readout instrumentation and supernova-readiness of XLZD, the next-generation dark matter experiment'.

assistant: **Concept**

Understanding the nature of dark matter (DM) is a primary question in modern physics. Dual-phase liquid xenon (LXe) time projection chambers (TPCs) have led the search for particle DM, particularly for DM candidates above ~5 GeV. Building on the success of current experiments like XENONnT and LZ, the XLZD consortium aims to design, construct, and operate a 60-80 t LXe-TPC to probe WIMP-nucleon cross-sections down to the neutrino fog limit. XLZD will also search for low-energy solar neutrinos, neutrinoless double beta decay, solar axions, and supernova neutrinos, making it a genuine ""rare event observatory.""In this context, I propose to enhance the optical readout system for the LXe skin detector using silicon photomultipliers (SiPMs) and to study the sensitivity of the TPC to supernova (SN) neutrinos. The first part of the project is designing and characterizing VUV SiPMs and a minimal-radioactivity readout system for the LXe skin region. Achieving a 100 keV threshold will improve gamma-ray tagging from the active target, reducing electronic recoil background and, to a lesser extent, the nuclear recoil background. A prototype will be developed and tested at Imperial College London (ICL) and later at the University of Zurich (UZH), including in LXe.The second part focuses on enhancing the SN detection capabilities of LXe detectors, including contributions to an online SN monitor for the LZ experiment and its integration with the Supernova Early Warning System (SNEWS). The project will assess XLZD's sensitivity to SN neutrinos, evaluating its potential impact on neutrino property measurements and SN model discrimination, and contribute to the design of a parallel DAQ system for near-continuous SN monitoring.The proposed research will significantly advance the design and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Search for axion-like particle produciton in kaon decays at CERN-NA62 experiment' (KaonToALP) under Horizon 2020.

assistant: **Objectives**

It is proposed to perform the first search for production of a short-lived axion-like particle (ALP) in charged-kaon decays (K+ --> pi+a), which decaying promptly into a di-photon final state, using world's largest data set of charged kaon decays collected by the NA62 experiment at CERN in 2016-18. New powerful constraint on the ALP phase space will be established; a possible ALP discovery would be a breakthrough in particle physics. To achieve credible results on the ALP search, it is mandatory to understand the main Standard Model background process K+ --> pi+ gamma gamma. Therefore a comprehensive study of this process is also proposed, including a re-analysis of the inputs to the description of this decay within Chiral Perturbation Theory, and the most precise measurement of this process to date. This measurement by itself represents an important test of the theories describing low-energy dynamics. These novel measurements are based on an existing data sample collected recently, thereby minimizing the associated risks.


**Keywords:** Rare decays, kaon decays, axion-like particle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Environmentally Friendly Aviation for all Classes of Aircraft' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The EFACA project consists of 6 main objectives at 3 levels. Level 1 consists of three TRL3 demonstrations of technologies relevant to the greening of aviation: (WP1) bench testing of a gearbox combining input from gas turbine and electric motor for an hybrid turbo-electric propulsion system for a propeller-driven regional aircraft; (WP2) comparative testing of fuel cells with conventional liquid and novel phase cooling, to show the benefits up to 20% of the latter in higher net power, reduced heat losses, and smaller volume and weight also reengineering of fuel cell and structural components to increase power-to-weight ratio up to 80%; (WP3) static ground testing of a complete liquid hydrogen fuel system from cryogenic tank to vaporization and combustion in a wide range of operating regimes and simulation of application to the speed and altitude flight envelope of jet airliners. Level 2 consists of two preliminary designs: (WP7) an 80-seat 1000-km range regional propeller driven aircraft including design and integration of hybrid turbo-electric propulsion; (WP89) a 150-seat 2000-km range jet liner with liquid hydrogen fuel including design and integration of cryogenic tanks and fuel system. At level 3 a road map (WP10) for the achievement of the EU environmental targets for aviation synthetizing conclusions in four steps: (i)  current status on (WP4) emissions and (WP5) noise versus future targets and gap to be covered; (ii) assessment of relevant technologies to cover the gaps, including (WP6) battery electric and (WP9) sustainable aviation fuels, besides hydrogen (WP7) fuel cells and (WP8) turbines; (iii) most suitable technology for each class of aircraft (light, small and medium regional, single and twin aisle jetliners), and maturation time of the technology; (iv)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Validation of the disease model  and therapy for retinitis pigmentosa 11' in the context of a Seventh Framework call.

assistant: **Objectives**

With a prevalence of 1 in 3500 retinitis pigmentosa (RP) is a significant cause of blindness in the Western world. RP is a group of hereditary retinal disorders, for which there is no effective treatment. It is mostly caused by mutations in genes related to the biochemistry of photoreceptors. PRPF31, however was the first ubiquitously expressed gene implicated in this disorder. Mutations in this gene are responsible for one of the commoner forms of autosomal dominant RP (RP11) with implications for a significant proportion of patients. Overall it has been noted that patients who manifest the disease present a severe form of retinal degeneration, often losing vision completely by the third decade. With the cloning of PRPF31, a novel class of genes, i.e. splicing factor genes, causing RP was revealed (PRPF3, PRPF8, PAP-1). These four genes are associated with a common splicing complex, U4/U6.U5 snRNP, and they are likely to share the molecular mechanism of the pathology. It has been noted that in families affected by PRPF31 mutations, manifestation of the disease is also dependent on the expression level of the wild-type PRPF31 allele. Thus, high levels of wild-type PRPF31 protein, can override the effect of mutant copy of the PRPF31 gene. This is known as partial penetrance and can be viewed as nature’s way of curing the disease. Learning from the clinical data, I would like to establish an RP11 animal model to validate the therapeutic effect of increasing PRPF31 expression. At first instance, Prpf31 levels in mouse will be reduced with RNA interference (RNAi) technology and the course of the disease progression will be assessed. The RNAi will be administered by subretinal injections. Subsequently, the rescue of the retinal phenotype will be brought about with delivery o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Transglutaminase in disease: a novel therapeutic target?' (TRANSPATH), addressing dissemination and exploitation.

assistant: **Impact**

TRANSPATH is a multisectorial Network designed to facilitate the exchange of knowledge and technology between 7 leading European research teams and 3 SME partners and 2 associate SME Partners involved in basic and applied research into transglutaminase (TG) related human diseases.  Its ambitions are to accelerate the development of new strategies for the treatment and diagnosis of human diseases related to transglutaminases, including metastatic cancer, neurodegeneration and celiac disease.  The subject is highly relevant as deregulation of tissue transglutaminase activity is observed in a number of human diseases while the exact mechanisms are still largely unknown.  The project targets this unmet clinical need.  The main objectives are :1) to establish the molecular nature of the role of transglutaminases in the pathogenesis of diseases which are known to involve these multifunctional enzymes with a view to developing novel specific inhibitors and new therapeutic approaches which will have a major impact on their treatment ;2) provide an extensive cross sectorial scientific and supporting training network that will increase the capabilities of highly skilled researchers for the European biotechnology industry and academia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European Twin Study Network on Schizophrenia' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Schizophrenia is one of the most severe and common mental disorders and a major challenge to health sciences in the European area and worldwide. Recent advances in neuroscience have shown disturbances of brain structure and function in schizophrenia. The genetic component is, however, complex and poorly understood. For this purpose, twin studies are a powerful approach in identifying endophenotypes, i.e. specific heritable biological markers, which might differentiate subgroups of schizophrenia with distinct genetic underpinnings, brain pathology, clinical course, and treatment response.The EUTwinsS consortium is a multidisciplinary network of European partners using neuroimaging, neurophysiology, and neurocognitive methods, as well as molecular genetics approaching the problem of schizophrenia by studying twins with this disease. It aims to combine several EU collaborations into the largest twin study on schizophrenia so far. The scientific programme of EUTwinsS will consist of studying both the phenotype (e.g. brain structure, cognitive function etc.) as well as the genotype (e.g. specific genetic markers) in this unique sample to allow the combination of multiple approaches to evaluate potential endophenotypes. Identifying how specific genes influence brain structure, function and cognition in order to predispose to schizophrenia will help to better understand this devastating disease.At the same time, EUTwinsS is a training network serving the need for state-of-the-art training in a highly multidisciplinary field involving scientists from various backgrounds. EUTwinsS will combine a number of high-quality practical training with a broad background in neuroscience, as well as problem-based approaches. Local training in the participating centres will be combined with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Intelligent physiological navigation and control of web-based applications'.

assistant: **Objectives**

The IPCA project aims to develop a new intelligent interaction mechanism that will enable people with severe motor and speech disabilities to control standard and especially web-based applications. The system will be based on a flexible combination of existing non-invasive sensors and encoders able to control different physiological parameters (EEG, EMG, RR/RA, etc.), and a set of software tools that will allow the user to interact with existing computer applications. IPCA will also develop a Smart Web Browser, based on top of existing web clients, that will facilitate the user interaction with different Internet applications and services by tapping into their semantics and optimising the interaction mode to the user preferred mode. IPCA will explore its applicability to other devices, context-based handicapping situations and ambient intelligence tools. IPCA will analyse the influence of emotional response to increase user satisfaction.DESCRIPTION OF WORKThe IPCA consortium is composed by four members including an international user group of people with disabilities, a commercial company with expertise in the area and two research centres with a wide experience in interface design and ergonomics issues for people with special needs (D&E).The IPCA project is divided in two components:* Development of a Multi-channel Monitoring System (MMS), based on non-invasive sensors able to control several physiological parameters from the user such as: Electro-encephalography, Electromyography, Respiration rate and amplitude, etc. The MMS will allow multiple sensor combinations tailoring the input parameters to different user characteristics. Furthermore, the system will be able to integrate other physiological parameters (e.g. heart rate) that give indications of the user attentiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A Sequence Classification Framework for Human Language Technology' under Horizon 2020.

assistant: **Concept**

This project will develop a unifying framework of novel methods for sequence classification and thus make a major break-through in automatic speech recognition and machine translation, advancing these areas of human language technology (HLT) beyond state-of-the-art. Despite the huge progress made in the field, the specific aspect of sequence classification has not been addressed adequately in the past research in these disciplines and remains a big challenge. The proposed project will provide a novel framework under consistent consideration of the leading aspect of sequence classification. It will break the ground for a deeper, more comprehensive foundation for sequence classification and pave the way for a new generation of algorithms that will put human language technology on a more solid basis and that will accelerate progress in the field across several disciplines. The leading research objectives are: 1. A novel theoretical framework for sequence classification. 2. Consistent sequence modeling across training and testing, which is specifically lacking in machine translation. 3. Adequate sequence-level performance-aware training criteria to learn the free parameters of the models. 4. Investigation of (true) unsupervised training for HLT sequence classification: its principles, its prerequisites, its limitations and its practical usage. The study of these four problems will provide key enabling techniques for HLT sequence classification in general that will carry over to and create high impact on the areas of speech recognition, machine translation and handwritten text recognition. Using our top-ranking research prototype systems, we will verify the validity and effectiveness or our research on public international benchmarks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Conducting organic materials for tissue engineering and drug delivery' under Seventh Framework.

assistant: **Concept**

Tissue engineering aims to facilitate the re-growth of damaged or diseased tissues through the design of three-dimensional scaffolds and has implications for society in terms of treating spinal cord injuries and degenerative brain diseases. The overall objective of this research programme is to design, synthesize and develop new conducting and biodegradable scaffold materials with the capacity to deliver drugs or growth factors for applications in tissue engineering. To achieve this, three approaches are being considered. The first is the formation of nanoparticles and/or nanofibers of polypyrrole (PPy) with existing biodegradable polymers to form composites. Secondly, conducting polymer materials with both conducting and non-conducting segments will be developed. And finally, this objective will be examined using a natural polymeric material, melanin. These approaches will be achieved through a number of chemical and electrochemical techniques including electrospinning, electropolymerization and chemical vapour polymerization, as well as, organic synthesis and spin coating. These materials will also be studied in terms of their biodegradation rates, biocompatibility and their ability to promote cell attachment, cell proliferation and to stimulate nerve cell regeneration. In achieving this objective Dr. Hendy will develop new experimental skills, gain expertise in the synthesis of advanced polymeric materials for controlled drug delivery and tissue engineering and gain expertise in all aspects of a researcher’s role. In this area of biomaterials, MIT is the most prestigious University in the world, allowing Dr. Hendy to become exposed to new equipment, which in turn will help develop a host of new complementary skills; consequently this training, will have a key impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Investigation of the risk of cyanide in gold leaching on health and environment in central asia and central europe' (IRCYL) targeting Fifth Framework.

assistant: **Abstract**

Rich gold resources are a relevant economic potential of NIS. Cyanide leaching, introduced by joint venture companies of NIS and Western states, can be considered a severe hazard for environment and health under conditions of insufficient regional infrastructures. In 1998, an accidental cyanide spill in Kyrgyz Stan caused severe thread for environment and health. To reduce the probability of such disasters and to provide inadequate environmental risk and emergency management. the lacy objectives are the investigation of the impact on environment and health of the Kyrgyz Stan accident by means of an epidemiological study including exposure and risk assessment, the development of expertise in disaster medicine including the provision of a cyanide disaster management pan, and the provision of a forum for risk communication about the cyanide leaching technology between stakeholders including a comprehensive review of technological alternatives and cost-benefit analyses. The IRCYL consortium comprising a broad interdisciplinary panel of scientists as well as industry and industrial consultants is especially suitable to achieve these objectives.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Community Friendly Miniliner'.

assistant: **Objectives**

UNIFIER19, the Community Friendly Miniliner, is an innovative commuter concept specifically designed to enable a new, environmentally sustainable and cost-efficient air mobility solution. This 19-passenger near-zero-emission aircraft is designed to provide a diffused service connecting smaller airports among them and with hubs, accommodating both scheduled and on-demand shuttle flights. The ability of the UNIFIER19 concept to capture the mobility demand for short- and very short-haul travel rests on a dedicated market study focusing on two scenarios: the “miniliner”, serving a potentially huge small airport network, and the “microfeeder”, providing a rapid transfer to hubs from local airports and even unpaved airfields. The capability to achieve substantial emission reduction performance is based on the adoption of modular propulsive solutions including different propellers and different combinations of battery and range-extending technologies. The propulsive architecture is integrated with airframe design, in the quest for maximum aerodynamic advantages, while guaranteeing producibility and maintainability of the design solution.The result is a family of aircraft sharing a single airframe, accommodating multiple cargo and passenger-seating layouts, as well as multiple motive power-generation solutions. Powertrain modularity eases future upgrades via supplementary type-certificates, granting an extended commercial life.Aiming to a reduction in CO2, NOx and acoustic emissions by at least 20% compared to the 19 seaters in service today, UNIFIER19 shall offer a new mobility experience for our communities that is as easy to use as a bus. UNIFIER19 shall exploit the sparse, underused European small airport network avoiding overwhelming burdens for new ground infrastructures