RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular basis of misfolding diseases - human lysozyme as an amyloidogenic protein model' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content Amyloidosis is associated with a range of major diseases such as Alzheimer's and Creutzfeld-Jabob's. Amyloid fibril formation is due to the accumulation of a normally soluble protein in a non soluble conformation. Different results suggest that this abnormal aggregation is due to misfolding of the protein which forms the aggregates. For this reason the study of the folding pathways involded in systemic amyloidosis due to lysozyme mutants seems to be a major way to understand the amyloidosis process common to every amyloidic disease. Lysozyme folding has been extensively studied, and the comparison of wild type protein and mutant proteins forming the aggregates should allow to identify the intermediate responsible for aggregation, and probably to design an inhibitor to stop this aggregation. Denis Canet will be involved in this project for its kinetic expertise, to study the unfolding and refolding kinetics of the human lysozyme mutants, and to characterize the structure of the folding intermediate leading to aggregation. His ability to run rapid kinetic experiments, and to interprete the data collected, particularly with the help of computer simulations, will be of great interest for this project, in a work in collaboration with protein structure and amyloidosis specialists. Training content (objective, benefit and expected impact) Insight into the amyloidic aggregation process. Training in protein folding and structure, and new techniques such as real time NMR.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of method for protection of underground pipelines by internal application of a rapid reacting coating' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Pipelines are preferably underground but at leakages this is not advantageous. A few techniques have been developed that can repair pipelines internally while keeping them underground, but still many problems exist like at pipe diameter variations, branches and bends, by local adhesion failures and decrease of pipe volume. Goal of an intended project is to develop a new innovative technology by application of a rapid reacting spray coating. Combined with innovative cleaning and on line inspection, this technique will overcome existing problems, give a two times faster protection of pipe interiors and thus safe much energy and maintenance costs. The technique will be developed for corroded steel, concrete and PVC making a broad penetration on the European market possible. Several SME-companies will combine their knowledge and experience in cleaning, coating and inspection areas and will use research measures of RTD companies to develop the system, ready for the market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Developing new therapies for Batten disease' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The goal of BATCure is to advance the development of new therapeutic options for a group of rare lysosomal diseases - neuronal ceroid lipofuscinoses (NCL) or Batten disease. There are > thousand affected across Europe, with a combined incidence of c.1:100 000. The NCLs are devastating and debilitating genetic disorders that mainly affect children, who suffer progressive dementia and motor decline, visual failure and epilepsy, leading to a long period of complete dependence on others, and eventually a premature death. Existing palliative treatment can reduce, but does not eliminate, the burden of seizures and the progressively worsening effects on the whole body due to decreasing CNS influence and control. There are no curative treatments in the clinic for any type of NCL. We will follow a novel integrated strategy to identify specific gene and small molecule treatments for three genetic types of Batten disease that include the most prevalent world-wide, juvenile CLN3 disease, and in southern and mediterranean Europe, CLN6 and CLN7 diseases.To develop new therapies for these 3 types of Batten disease, BATCure will:1. Create new models, tools and technologies for developing and testing therapies2. Further delineate disease biology and gene function to identify new therapeutic target pathways utilising yeast and pluripotent stem cell models3. Identify biochemical therapeutic target pathways, facilitate effective evaluation of preclinical therapies and improve diagnostics4. Extend a comprehensive natural history beyond the brain to include cardiology, the spinal cord, PNS, psychiatric and metabolic changes5. Identify new and repurpose existing small molecule therapy6. Triage new compound treatments in zebrafish, a high-throughput small vertebrate model 7. Deliver and monito
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Radiation Response Models for Personalised Radiation Oncology' (RADRESPRO).

assistant: **Innovation**

Clinical radiotherapy for cancer has seen dramatic improvements in recent years, driven by developments in imaging and delivery techniques. However, the ability to deliver radiation is now out-stripping radiotherapy planning techniques. Despite the goal of radiotherapy – tumour control – being primarily biological, radiotherapy planning tools focus on a purely physical metric: dose. This has significantly hampered the translation of knowledge gained from laboratory radiobiology to clinical settings. This project will lay the foundation for a unified model of therapeutic in vivo radiation responses by developing a computational model to describe these systems in a bottom-up fashion, integrating not only macroscopic parameters such as tumour size and dose, but also microscopic parameters such as radiation track structure and the cellular micro-environment.As part of this project, collaboration will be developed between the radiation biology group in the  Centre for Cancer Research and Cell Biology, Queen's University Belfast, and Massachusetts General Hospital. The applicant will take advantage of time spent in MGH to gain skills and experience in the delivery of proton therapy, broadening his technical background and placing him in a strong position to contribute to the development of this increasingly important treatment modality upon his return to the EU.These models will enable a more natural integration of physical and biological parameters into radiation response models, facilitating improved knowledge transfer from laboratory to clinical practice. Through this, they can be used to address outstanding questions in modern radiotherapy, such as identifying the optimum dose distribution and delivery schedule for individual patients, and understanding the differences in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A new  process for removal of odour from Post Consumer Waste Polymer for non-food applications – ODEX' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Although much progress has been made in recycling the easier polymer streams such as at-line production waste, or through specialist closed loop systems, the challenge to recycle Post Consumer polymer waste (mainly packaging from consumer goods such as food, sauces and detergents) is still strong, particularly for polypropylene and polyethylene.  These polymers strongly absorb odours from their contents, and form musty taints due to bacterial action in the waste stream, which currently needs uneconomic levels of cleaning before they can be recycled into high value products such as automotive fascias and building products.  Of all of the post consumer polypropylene waste produced, under 1% is recycled into high quality products; the rest is used in low value applications such as buried geotextiles, or is landfilled or incinerated. The ODEX process concept from Luxus, a recycling compounder for automotive plastics, has been specifically created to provide a cost effective method to deodourise polymers for higher value uses; it uses only the existing heat energy from the compounding process to drive the odourous compounds out of carefully designed pellets within a continuous at-line process.  This project is intended to validate the feasibility of the process and formulate a business plan, to underpin our future objectives of scaling it up to commercial application.  The future embodiment of the technology is envisaged as a turnkey or retrofit option for Luxus and other existing compounders as licencees, allowing them to provide high quality polymers from materials that would otherwise have been destined for landfill or incineration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Disruptive Digitalization for Decarbonization' (2D4D), addressing dissemination and exploitation.

assistant: **Impact**

By 2040, all major sectors of the European economy will be deeply digitalized. By then, the EU aims at reducing greenhouse gas emissions by 60% with respect to 1990 levels. Digitalization will affect decarbonization efforts because of its impacts on energy demand, employment, competitiveness, trade patterns and its distributional, behavioural and ethical implications. Yet, the policy debates around these two transformations are largely disjoint.The aim of the 2D4D project is ensure that the digital revolution acts as an enabler  and not as a barrier  for decarbonization. The project quantifies the decarbonization implications of three disruptive digitalization technologies in hard-to-decarbonize sectors: (1) Additive Manufacturing in industry, (2) Mobility-as-a-Service in transportation, and (3) Artificial Intelligence in buildings.The first objective of 2D4D is to generate a one-of-a-kind data collection to investigate the technical and socio-economic dynamics of these technologies, and how they may affect decarbonization narratives and scenarios. This will be achieved through several data collection methods, including desk research, surveys and expert elicitations.The second objective of 2D4D is to include digitalization dynamics in decarbonization narratives and pathways. On the one hand, this entails enhancing decarbonization narratives (specifically, the Shared Socio-economic Pathways) to describe digitalization dynamics. On the other hand, it requires improving the representation of sector-specific digitalization dynamics in Integrated Assessment Models, one of the main tools available to generate decarbonization pathways.The third objective of 2D4D is to identify no-regret, robust policy portfolios. These will be designed to ensure that digitalization unfolds in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Lorax Project: Understanding Ecosystemic Politics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The Lorax project is a comparative effort to expand our understanding of global political architecture through the consideration of a potential set of ‘missing cases’, namely supranational policy fields organized around regional ecosystems.  The project explores this question: Do regional politics around national border-crossing ecosystems share important resemblances and differ in significant ways from global politics? To address this question, the Lorax project analyzes the networks of actors, hierarchies between actors and diplomatic norms of the governance fields that have grown up around efforts to ‘speak for’ border-crossing ecosystems in three locations – the Arctic Ocean, the Amazon Basin, and the Caspian Sea. ‘Ecosystemic politics’ is meant to indicate regional-level political efforts justified by the shared management or discussion of collectively acknowledged ‘border-crossing’ ecosystems. Frequently, the political cooperation may be on issues that would be seen as environmental or regulatory politics relating to the ecosystem itself, but ecosystemic politics is not, by definition, limited to such questions of environmental politics. Rather, the word ‘ecosystemic’ gives the Lorax team a sense of where to look without presupposing the interests and issues that engaged actors may bring to those regional interactions. The project aims to generate new insights about the architecture and dynamics of global governance by rigorously researching and then comparing three cases of policy fields around national border-crossing ecosystems. The team will consist of the PI, a postdoc, a PhD and additional senior researcher capacity as needed. An ambitious, but achievable, publication plan (9 articles, 1 book) is mapped out to ensure rigorous finalization of results and diss
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Changing Energy Efficiency Technology Adoption in Households' in the context of a Horizon 2020 call.

assistant: **Objectives**

Modelling analyses typically suggest that policies accelerating the adoption of energy-efficient technologies (EETs) by overcoming barriers to energy efficiency in the residential sector provide benefits for individual households, the energy system and for society as a whole. Yet, implicit discount rates, employed to reflect households’ decision criteria and response to policy, are disputed in policy and academic circles. CHEETAH (CHanging Energy Efficiency Technology Adoption in Households) provides evidence-based input to energy efficiency policy design and evaluation, thereby supporting the market uptake of EETs in the EU residential sector. It contributes to the work programme by addressing the interrelations between microeconomic factors, sectoral energy demand and macroeconomic effects, relying on a consistent methodological framework.CHEETAH:• Provides empirical evidence on household response to established and new energy-efficiency policies and on factors driving adoption of EETs, accounting for differences across households, technologies, and countries. A multi-country survey (2000 interviews per country) will be carried out and analyzed econometrically• Assesses the impact of established and new policies energy demand in the EU residential sector until 2030 (meso-level). Established vintage stock energy models will be employed for appliances (FORECAST) and for buildings (Invert/EE-Lab) and linked with an agent-based modelling approach (ABM)• Explores the macro-level impacts of changes in microeconomic decision-making and energy-efficiency policy on employment, GDP and exports until 2030, relying on simulations with a recognized macroeconomic model for the EU (ASTRA)• Offers evidence-based recommendations for key energy efficiency policies and input for impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mapping complexity in language' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

This project addresses a fundamental paradox in linguistic theory: different components of grammar appear to rely on conflicting notions of structural complexity. For instance, the way nouns are inflected for number (e.g., singular/plural) suggests that plural forms are more complex than singular ones. However, the way these forms pragmatically compete to create meaning (e.g., implying ""exactly one"") suggests the opposite. This indicates that the processes governing pronunciation (morphological spell-out) and meaning (pragmatic competition) are sensitive to different types of complexity.The project's main objective is to resolve this paradox by developing a more nuanced, unified theory of linguistic complexity. This will be achieved through three steps. First, we will conduct a large-scale, cross-linguistic investigation to map the notion of complexity relevant to morphological spell-out, expanding beyond number to phenomena like case and pronouns. Second, we will critically examine and refine the theory of pragmatic alternatives to map the notion of complexity relevant to meaning competition. Finally, we will synthesize these findings into a single, coherent formal model that explains how different grammatical components access different levels of morphosyntactic structure.This research will significantly advance our understanding of the architecture of the human language faculty. By providing a more precise model of the interface between syntax, phonology, and semantics, the project will make key contributions to linguistic theory. In the long term, these fundamental insights can inform the development of more sophisticated and human-like language technologies in fields such as Natural Language Processing. The combined expertise of the applicant and the supervisor i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Fostering self-adaptive e-government service improvement using semantic technologies' (FIT) targeting Sixth Framework.

assistant: **Abstract**

For e-government initiatives to succeed, public services should be organised in a way to serve every citizen individually. Since citizens pose different access possibilities, skills and motivation, service delivery should be tailored to the widest possible end-user population. This adaptivity means that all citizens have access to the public services in a manner which is enabling and satisfying. It requires not only the personalized service delivery, but more important the extension of the service description by including dynamically changing citizens' needs. The overall objective of FIT is to develop, test and validate a self-adaptive e-government framework based on semantic technologies that will ensure that the quality of public services is proactively and continually fitted to the changing preferences and increasing expectations of e-citizens. FIT aims to:- Create a conceptual framework for realizing self-adaptive e-government (i) by taking into account users needs, domain knowledge and semantic descriptions of existing administrative processes and (ii) through ensuring continually improved services delivery, detecting new services and context-aware restructuring of existing services- Increase citizens' satisfaction by providing an intelligent and personalized front office through dynamically eliciting preferences of every user and proactive provision of context-sensitive and customized services/ information- Increase the adaptivity of the back office through semantic modelling of customizable administrative processes and embedding these models in the daily work- Enable knowledge sharing between front offices through semantic modelling of front offices best practice and efficient transferring of shared experiences to other front offices- Pilot and evaluate the FIT p