RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of n-type polymer materials used as alternative to soluble C60 derivatives and their use in organic solar cells', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The utilisation of conjugated polymers in solar cell active layers is based on a photo induced electron transfer phenomenon and first promising results came from donor/acceptor hetero-junction solar cell based on polymer/fullerene blends, the conjugated polymer being a p-type material and fullerene a n-type material. Since that first discovery, main research on donor/acceptor hetero-junction solar cells has focused on p-type materials and very little on n-type materials, with fullerene and its derivatives currently being the major electron acceptor studied and used in all developments. Conjugated polymers can be divided in two classes: p-type materials with hole transport properties as for example the well-know MEH-PPV and n-type materials with electron transport properties such as CN-PPV. So far, only a few reports have explored n-type conjugated polymers and the main efforts towards such materials were focussed on LED applications with almost none on solar cells. Dedicated conjugated polymers having n-type properties to be used as alternatives to fullerene C60 and fullerene derivatives PCBM in organic donor/acceptor hetero-junction solar cells are now a real need in the organic solar cell research community. The network SolarNtype - made of excellent academic (5 ), pure and applied non-academic research institutes (4) and industrial (1) partners from 7 Member States - will contribute to the design, synthesis and testing in devices of novel n-type electron acceptor" conjugated polymers for an application in organic donor/acceptor bulk hetero-junction solar cells. The multidisciplinary character of the SolarNtype network and the world recognition of the network partners will broaden the possibilities of the young and experienced researchers to acquire complementary s ki
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Nanofabrication of biomaterial surfaces for investigation of individual protein molecule adsorption'.

assistant: **Concept**

Implants placed within the body are of great clinical and social use in today's society. Initial protein adsorption to the surface of such implants critically influences integration of the implant and while being strongly dependent on surface properties, is not well understood. A detailed look at the interactions between nanofabricated surfaces and protein molecules is a key step towards better implant surfaces. The aim of the project is to isolate the interaction of individual protein molecules with surface features below lOnm in size, by using state-of-the-art nanofabricative techniques. The conformation and functionality of such proteins will be probed and the systematic variation of feature size and chemistry will be used to seek a relation between specific surface properties and protein adsorption characteristics. These biological model studies are likely to suggest new preparation methods involving biomolecules to obtain tailor-made, functional implant surfaces.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Biomimetic Cornea fabrication by 3D printing and adult Mesenchymal Stem Cell directed differentiation.' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

MIMECOR aims to develop an artificial and biomimetic cornea to achieve a major improvement in the quality of life of corneal disease patients, reducing their dependence on corneal transplants. This will be reached through the preparation and further modifications of a human-like cornea through the combination of additive manufacturing, stem cell transdifferentiation, and colonisation as an alternative to natural cornea donation. This approach is going to be a major breakthrough in Ophthalmology, as it will overcome the existing limitations of current treatments: it could become a reference in the therapy for specific corneal pathologies. The candidate researcher, Dr. Marć will provide to the project with her broad experience in applied preclinical research, gained in academic and industrial research groups of different European countries.  She will learn cutting-edge techniques in Regenerative Medicine applied to Ophthalmology, through the interaction with a multidisciplinary, collaborative, and creative environment with specialists in engineering, medicine, physics, biology, and biochemistry. The candidate will perfect research skills such as experimental design, scientific writing, open science and data analysis. Moreover, through diverse training activities and a non-academic placement at a small-medium enterprise (the largest monographic ophthalmological private hospital in Europe), Dr. Marć will also acquire transferable skills and experience in grant implementation, ethics in Responsible Research and Innovation, time management, and scientific communication and divulgation. Besides, this formative plan accommodates her needs with the capabilities of the hosting group and institution. All this knowledge and skills will be crucial for the career success of the resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Chaotic quantum transport in semiconductor superlattices and bose-einstein condensates' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

This project will investigate the classical and quantum properties of electrons in semiconductor superlattices (SLs) and Bose-Einstein Condensates (BECs) in optical lattices. The applicant and host have discovered that these systems have many unique and technologically important features. In particular, they exhibit a highly unusual type of chaotic motion, non- KAM chaos, which has attracted wide theoretical interest, but not previously been realized in experiment. Non-KAM chaos provides an innovative mechanism for controlling the transmission of electrons and photons through semi-conductor and photonic devices: a critical area for the development of quantum electronic devices and ultra-fast switching. The project will explore this mechanism through two mutually-supporting tasks, linking together semiconductor technology, ultra-cold atomic physics, and non-linear dynamics Task A. Effects of non-KAM chaos on quantum transport in SLs and analogous photonic devices. Key objectives are to:(a) Explain recent observations, in Nottingham, of giant resistance fluctuations associated with the onset of non-KAM chaos;(b ) Develop SLs optimized for using non-KAM chaos to control device resistance and effect ultra-fast switching. Task B. Effects of non-KAM chaos on alkali-atom BECs. Key objectives are to:(a) Investigate how the onset of chaos affects the BEC ground state and excitation spectrum;(b ) Motivate experiments, which will provide insights into the SL and photonic systems considered in Task A. The project will provide training in the state-of-the-art theoretical, computational and experimental techniques required for interdisciplinary research at the interface between quantum electronics, atomic physics and non-linear science. The results will strengthen the hosts' internat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'LaRGE SCALE FACILITY FOR MARINE PELAGIC FOOD CHAIN RESEARCH' in the context of a Fourth Framework call.

assistant: **Objectives**

The Marine Pelagic Food Chain Research Facility offers a combination of a strong scientific environment with outstanding experimental installations for research in a key area of marine natural reserves - the Pelagic Food Chain. (F ish Ecology was defined as a priority area in COM(93)95 European Fisheries Research.) The integrated high-quality research facilities offer a rare combination of possibilities for laboratory-based and natural environment research on planktonic food chain dynamics and early life history of fish and shellfish, fish recruitment and environmental health all within one hour travel distance. The LSF offers a sophisticated infrastructure of sea-water laboratories for studying impact of environmental factors on marine organisms and on sustainable juvenile production or marine fish and shellfish. An international laboratory in molecular marine biology organised on the EMBL model is proposed in Bergen. A floating laboratory for mesocosm studies is especially suited for large-scale experimental work on primary and secondary production, planktonic succession and environmental health under controlled conditions. A large-Scale semi-enclosed lagoon and an isolated basin are accessible and represent unique experimental installations or studies of food chain dynamics and larval fish ecology. Well described ecosystems ('Model environments'; accessible by research vessels) are appropriate for studies of natural and antropogenic factors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European graduate programme in social protection policy' (ESPP) targeting Sixth Framework.

assistant: **Abstract**

The objective of the European graduate programme in Social Protection Policy (ESPP) is to train a critical mass of young researchers in social protection and social policy in a European and multidisciplinary perspective by pooling the resources of 12 top r esearch institutes and universities in 8 EU-countries.Social Protection is a research area wherein many European institutes have built up serious expertise. However, no specialised PhD- programmes are found at universities. Most research- and training-grou ps at universities across Europe are relatively small. The proposed network pools the expertise and competence of a significant number of the top European scholars in the field. It also combines the input and the research perspectives from various discipli nes: economics, political science and other social sciences as it counts protagonists in the various disciplines among the supporting institutes. The ESPP programme brings together a significant part of the European expertise in social protection in order to provide a sound scientific foundation of EU social policy and in order to be able to attract the best young researchers in the world. The experienced researchers and teachers will contribute to a coherent PhD programme taught in a central location and s tudents/fellows will spend a significant period at one of the supporting institutes, while a tightly organised supervision and monitoring programme guarantees a successful start of a high level research career. The ESPP programme will build on the experien ce and the know-how of the host in implementing graduate programmes in the field of social protection. Excellence in teaching and research in Social Protection are the explicit objectives.The sustainability and the reform of European Welfare States, will b e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'INvestigating SDN Programmability ImpRovING optical South- and North- bound Interfaces' (INSPIRING-SNI).

assistant: **Innovation**

Population needs for Internet connectivity rely on carrier networks currently challenged by the ever-increasing network complexity, traffic volume, and dynamicity. Software Defined Networking (SDN) has entered the networking scene as an enabling technology that brings programmability to the network by decoupling the forwarding data-plane actions from the logic control-plane decisions through application programming interfaces. However, the variety of controllers governing different network segments and interfaces for control and management endangers actual carrier-grade SDN deployments.INvestigating SDN Programmability ImpRovING optical South- and North- bound Interfaces (INSPIRING-SNI) aims to enhance programmability in SDN ecosystems addressing two critical aspects. First, INSPIRING-SNI will control, manage and operate technology diverse environments through the SouthBound Interface (SBI) relying on innovative industry-driven standardization initiatives such as OpenROADM and the expertise of Dr. Garrich in experimental SDN applications for optical networks. Second, INSPIRING-SNI will develop an optimization-as-a-service (OaaS) framework for dynamic optimisation of multilayer backbone/metro networks (IP over optical) jointly with metro/access segments via the NorthBound Interface (NBI), greatly widening Dr. Garrich's background and empowering his career perspectives. The OaaS framework will be based on the open-source network planning tool Net2Plan, developed within the host group, that is receiving a growing international attention and funding from industry and academia. INSPIRING-SNI will include a strategic inter-sectorial secondment at TID to experimentally validate the SBI and NBI proposals and to provide to the host and Dr. Garrich a realistic perspective on tele
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Around Braids, Categories and Distances' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

This proposal aims at addressing classical problems about the braid group by making use of recent advances in higher representation theory. More precisely, I want to use Khovanov-Seidel categorified Burau representation and Bappat-Deopurkar-Licata's work on stability conditions to work on the faithfulness problem for the Burau representation and on the Haagerup question for the braid group.The faithfulness of the Burau representation for the 4-strand braid group is one the oldest and most tantalizing problems in braid group theory. I strongly hope that new light can be shed on it by using recent tools from higher representation theory. My strategy is to develop with Licata a ping-pong argument, which will rely on  a diagrammatic description of morphisms in the category of bimodules over the zig-zag algebra. Then a fine control of the decategorification process will be needed, that I will study with Bonnaf.Braid groups also play a major role in geometric group theory, a field of research that arose under the impulse of Gromov. Amongst open questions, knowing whether the braid groups enjoy the Haagerup property is a central one, as it has ties with several open conjectures. I plan to use Bappat-Deopurkar-Licata's work on Bridgeland stability conditions on the category of representations of the zig-zag algebra to build a space with walls on which the braid groups in type A would act. This would yield a proof of the Haagerup property for braid groups in type A.Both of these work problems are major challenges in braid theory, and my approach to study them will create innovative mathematics entangling tools from several fields (geometric group theory, triangulated categories, diagrammatic algebra). This project will only be made possible thanks to the help of world-leading ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrative phagosomal biology: antigen presentation and developmental programs in dendritic cells' (PHAGODC) targeting Seventh Framework.

assistant: **Abstract**

Integrative phagosomal biology: antigen presentation and developmental programs in dendritic cells   Dendritic cells phagocytose incoming pathogens and dead cells in peripheral tissues, and then migrate to the draining lymph nodes where they deliver to lymphocytes all the  information  required for the initiation of adaptive immune responses. This information relates to the nature of the pathogen, which is sensed, both directly through pattern recognition receptors (including Toll-like receptors, TLRs), and indirectly through different receptors for cytokines and stress factors. This information also concerns the structure of the antigens, which will be presented to T lymphocytes in the form of proteolytic peptides loaded on MHC molecules. Phagosomes play a critical role in the processing of antigens for presentation to both MHC class II-restricted CD4+ T cells, and to MHC class I-restricted CD8+ T cells (a process called cross presentation). Importantly, antigen processing and presentation to T cells is influenced by the environment of the dendritic cells and by the type of TLR-ligands engaged. The present project aims to identify the molecular basis for the regulation of phagosomal functions (including oxidation, pH control and degradation) and antigen processing during the different developmental programs of DCs. Our main specific aims are: 1) to analyse the regulation of the phagosomal function during dendritic cell maturation, 2) to identify novel molecular players and pathways in antigen cross presentation using shRNA- based screens, and 3) to image dynamically phagocytic dendritic cell functions, in vitro and in vivo. This project will provide an integrated vision of the phagosomal function of dendritic cells and of its regulation during dendritic cell maturation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dynamic control of membrane curvature and its role in membrane protein assembly' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Changes in the curvature of the cell membrane play an important role in many important biological processes, including cell division, vesicle trafficking, and neurotransmission. These changes in morphology are not just a passive consequence of other events in the cell, but can also drive the action of other proteins. For example, changes in curvature are thought to affect protein binding, the gating kinetics of ion channels, and to direct the localisation of proteins in vivo.Although current methods can measure the presence of such interactions, they cannot directly measure real-time changes in membrane curvature or correlate individual protein binding events with changes in curvature. Dr Junhong Lu has a proven track record in Biological Atomic Force Microscopy. We propose to combine his expertise with new synthetic mimics of the cell membrane recently produced in the laboratory of Dr Mark Wallace at Oxford University. This combination of methods will enable us to manipulate and characterize the curvature of the cell membrane, and study its effects on protein function using single-molecule methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'EPiTB: Addressing an unmet need: same day diagnosis of extra-pulmonary TB in a high burden setting.' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Better diagnostic approaches are required to improve TB control in Africa, which is suboptimal. One neglected aspect of TB diagnosis is that of extrapulmonary TB (EPTB), which comprises ~15% of the TB caseload. However, in HIV-endemic settings over one third of cases are due to EPTB (the most common manifestation being pleural TB). Frontline same day sputum-based diagnostic tools such as GeneXpert perform poorly when using fluid derived from EPTB-specific compartments (e.g. pleural fluid). Indeed, GeneXpert sensitivity in pleural TB is ~35%. ADA, the current standard of care used in clinical practice has poor specificity, especially in pericardial TB and TB-meningitis (see preliminary data). By contrast, unstimulated interferon-gamma (not T-cell-based IGRAs that require overnight stimulation) is an excellent biomarker for the diagnosis of EPTB (confirmed in 2 meta-analyses). A South African university start-up has now developed a low-cost same-day EPTB diagnostic test (IRISA-TB), which has been evaluated and published in several small clinical trials (see main proposal) and is locked-in for scale-up dissemination in 2022. The test is CE marked, SAHPRA approved,  and endorsed by the Global Fund. This proposal encompasses a large prospective multicentric study (n= 2170 patients) of IRISA-TB in various forms of EPTB (pleural, pericardial, and peritoneal TB, and TB meningitis). The proposed study (EPiTB) has excellent fidelity with the EDCTP call because it will enable “the registration of a new health technology through pragmatic effectiveness studies”, “enable uptake of results into clinical practice” and facilitate WHO endorsement. Thus, EPiTB will drive the facilitation and uptake of an important new TB diagnostic test in Africa. Importantly, an African-invented and des