RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Exploiting intra-species diversity to identify genomic properties that affect the cell biology, proliferation and pathogenicity of Klebsiella pneumoniae' (KLEBSCELL) targeting Horizon Europe.

assistant: **Abstract**

Klebsiella pneumoniae is an opportunistic pathogen that can cause particularly serious disease and mortality in immune-compromised, elderly, or otherwise vulnerable individuals. A high burden of mortality is attributed to K. pneumoniae: a 2019 study estimated that K. pneumoniae was associated with 790.000 deaths that year. Due to its incidence, mortality, and growing antibiotic resistance, the World Health Organization placed K. pneumoniae at the top of the Bacterial Priority Pathogens List in 2024, highlighting its danger to public health. Despite the high healthcare burden posed by K. pneumoniae, it remains a rather understudied pathogen, particularly regarding non-canonical virulence factors. Antibiotic resistance, for example, is rather well-studied in the pathogen, but our understanding of K. pneumoniae physiology, including the keys to its growth, replication, and survival in diverse environments is limited. K. pneumoniae displays extensive intra-specific diversity, with its pangenome encoding close to 30.000 protein-coding sequences. The general goal of this proposal is to exploit the extensive intra-species diversity of K. pneumoniae to determine how specific genomic properties affect cellular physiology, contribute to growth and proliferation, and underlie pathogenicity. The functional role of selected regions will subsequently be determined in more detail. K. pneumoniae intraspecific diversity will be investigated using a library of 100-200 strains across different growth conditions and antibiotics. A high-throughput cell imaging system will be used to collect various phenotypic measures. Next, genomic studies will uncover genetic differences among the strains, and these differences will be connected to phenotype. Finally, genetic manipulation will be used to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Coordination of Research e-Infrastructures Activities Toward an International Virtual Environment for Biodiversity' (CReATIVE-B).

assistant: **Concept**

ESFRI initiatives with a need to work on a global scale will have to collaborate with international comparable partners. The CReATIVE-B project will seek to support the interaction between the LifeWatch ESFRI Research Infrastructure with RI on biodiversity and ecosystems research in other parts of the world. The immediate objective is to define a road map for interoperability on the technological level, on the governance level and on the interrelation with the scientific communities using the RIs. The project will therefore be a catalyst for worldwide collaboration in this field by supporting and initiating coordination activities of these RIs. The greater objective of this collaboration is to serve the goals of GEOSS. At the same time, the international outreach of LifeWatch can lead to further international collaboration on interoperability of these infrastructures to even better serve research communities worldwide. In order to do so, CReATIVE-B will initiate with the international 'sister' infrastructures to have a second edition of the e-Biosphere conference, to be organized in 2013, and contribute to this conference. In achieving the goals of this coordination and support action, CReATIVE-B will further support the European Commission flagship, vision 2020.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrated AI Diagnostics in Breast Cancer' (GRANITE).

assistant: **Innovation**

In EU-27, it is estimated that >355,000 were diagnosed with breast cancer (BC) in 2020. Initiatives to reduce this burden in Europe involve early and precise diagnosis in the standard-of-care management to decrease unnecessary or insufficient treatment. Notably, precision medicine in BC is still in its infancy and is becoming even more critical with neoadjuvant chemotherapy (NAC), a standard of care treatment protocol in HER2-positive and triple negative subtypes. Recently, the use of digital diagnostics with AI is gaining momentum since it shows great promise towards accelerating personalized BC patients’ pre- and post-NAC predictions. While AI paves the way to next generation diagnostics, this has yet from been translated as a) it mostly operates in single data modalities that fail to capture the complex disease alterations, b) integrated AI usually suffers from data incompleteness usually leading to models trained with limited data that fail to generalize to new patients and/or that are not able to integrate partially observed multimodal information from the whole population. GRANITE focuses to address these unmet needs and goes beyond the state-of-the-art, fusing the most relevant standard of care data (radiology, pathology, clinical, demographic), leveraging novel AI and radiomics algorithms. GRANITE will deploy pre-trained deep learning models that will be fine-tuned, technically validated and clinically evaluated against pertinent clinical data of non-metastatic BC cases from the Bank of Cyprus Oncology Centre, Cyprus. We will engage with the AI4HI project to transcend FUTURE-AI guidelines (Fairness, Universality, Traceability, Usability, Robustness and Explainability; future-ai.eu) into GRANITE towards generating real-world evidence and making our AI technology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Improving the precision of behaviour change theories: Development and validation of a computational model of lapse risk in smokers attempting to quit' (COMPLAPSE).

assistant: **Innovation**

Tobacco smoking remains the leading preventable cause of premature morbidity and mortality in Europe. Gold standard treatment for smoking cessation includes pharmacotherapy and behavioural support. However, smoking lapses  influenced by momentary fluctuations in cravings and social cues  are a key source of treatment failure. COMPLAPSE aims to advance the state-of-the-art by developing and validating a dynamic computational model of lapse risk, improving the precision of static behaviour change theories to account for observed complexities and laying the foundation for dynamically tailored, person-centred digital smoking cessation interventions for increased effectiveness. COMPLAPSE is interdisciplinary in scope  drawing on know-how from behavioural science, engineering, and computer science  and directly contributes to Europes Path to the Digital Decade and its Strategic Framework for the Prevention of Non-Communicable Diseases. First, a conceptual model will be developed by articulating a diverse group of stakeholders (e.g., researchers, policymakers, smokers) dynamic predictions through participatory systems mapping. Next, a computational model will be developed through formulating mathematical equations for each model component, followed by a series of simulations to iteratively refine the model to align with stakeholders predictions. Finally, the model will be validated against temporally dense experience sampling and sensor data collected in smokers daily lives to critically examine whether the computational model outperforms static state-of-the-art theories. The research objectives are linked to key training, knowledge transfer and communication activities to advance the researchers expertise and transferrable skills, enabling her to develop independence; valoris
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enabling European SMEs to remediate wastes, reduce GHG emissions and produce biofuels via microalgae cultivation' (BIOALGAESORB) targeting Seventh Framework.

assistant: **Abstract**

The BioAlgaeSorb collaboration will benefit European SME-AGs in diverse business sectors by developing technologies for remediating and valorising industrial and agricultural/aquacultural effluents via microalgae cultivation. The resultant microalgal biomass will form a carbon neutral, environmentally sustainable raw material that is a source for commercially valuable end products, among them renewable energy. The set task is to utilise unwanted effluents as nutrient sources for photosynthetic microalgae, thereby reducing effluent discharge by SMEs and yielding high quality biomass which will be harvested and upgraded using an integrated biorefinery approach into valuable products. Leading commercial systems for microalgae cultivation will be optimised for capturing inorganic nutrients from aqueous effluents (intensive agriculture and aquaculture; municipal anaerobic digesters) and CO2 from power plants, thereby mitigating the environmental impacts of these sectors and contributing to the European Low Carbon Economy via a new source of biomass-based biofuels, and by reducing the discharge of GHG to the atmosphere. Novel physical processes will be developed to efficiently harvest, stabilise and fractionate microalgae biomass for downstream conversion into valuable products. An innovative biorefinery approach will be adopted incorporating biomass pyrolysis (liquids, gas and char) for bioenergy and biofuel production, as well as separation into lipid, protein and carbohydrate fractions. Processes will be optimised for transforming micoalgal lipids into second generation transport fuels. Biomass extracts and purified compounds (eg, omega 3 fatty acids, pigments) will also be developed for use as food and feed additives. A holistic approach will be used throughout the projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A Healthy Diet for a Healthy Life - Coordination Action' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The overall objective of the CSA is to support the development and the implementation of the Joint Programme Initiative A Healthy Diet for a Healthy Life (HDHL) promoting healthy lifestyles. The CSA will coordinate the activities within the Joint Programming Initiative and support the development of a strategic agenda for harmonised and structured research activities in the area of food, nutrition and health.VisionThe vision of the JPI on A healthy diet for a healthy life is that in 2030 all Europeans will have the motivation, ability and opportunity to choose a healthy diet from a variety of foods and the incidence of diet-related diseases will have decreased significantly.StrategyJoint programming or effective integration of research in the food-, nutritional-, social- and health sciences with enough critical mass will deliver innovative, novel and improved concepts and knowledge that will contribute significantly to the construction of a fully operational European Research Area on the prevention of diet-related diseases and strengthen leadership and competitiveness of the agri-food industry.Strategic goalTo change dietary patterns based on developments in food-, nutritional-, social- and health sciences and develop new innovative product formats, that will, together with concomitant changes in physical activity, have a major impact on improving public health, increasing the quality of life and prolonging productive life.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Decoding epistatic genome/RNome interactions in eukaryotic fitness gain using Leishmania parasites as a unique model system' (DECOLeishRN), addressing dissemination and exploitation.

assistant: **Impact**

Darwinian evolution plays a central yet poorly understood role in human disease. Iterations between genetic mutation and environmental selection drive cancer development, microbial infection and therapeutic failure, thus increasing human mortality. The molecular mechanisms that harness the deleterious effects of genome instability to generate beneficial phenotypes in these pathogenic systems are unknown. Here we investigate this important unsolved question in the protozoan parasite Leishmania that causes devastating human infections. In the absence of transcriptional regulation, these early-branching eukaryotes exploit genome instability to regulate expression by gene dosage. Leishmania thus represents an ideal system to investigate how genome instability drives fitness gain in fast evolving, eukaryotic cells, such as observed during cancer development. Synergizing our expertise in genomics, evolution, systems and RNA biology, we have recently made several breakthrough discoveries that link parasite fitness gain to epistatic interactions between co-amplifying genes of small, non-coding RNAs, which program epitranscriptomic and translational regulation. We hypothesize that these genome/RNome interactions generate the phenotypic landscape underlying Leishmania fitness gain. Our proposal investigates this ground-breaking concept through two Specific Aims that (i) combine experimental parasite differentiation and evolution in vitro and in vivo to reveal molecular mechanisms underlying Leishmania predictive adaptation and fitness gain, and (ii) investigate how RNA modification and non-coding RNAs contribute to adaptation by regulating mRNA stability and translational control. Our findings will be highly relevant to other fast growing, eukaryotic systems that rely on genome i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Shaping cortical computations via higher-order feedback'.

assistant: **Concept**

Our ability to flexibly adapt to changing environments depends on how we perceive, prioritize and act on stimuli. This involves actively integrating our current sensory experiences with our prior knowledge of the world and the surrounding context. Stimulus perception is influenced by contextual top-down signals from areas higher up in the processing hierarchy that carry information about internal state, attention and future actions to early processing stages where they are combined with bottom-up inputs. Commonly referred to as “feedback”, these top-down signals are multi-faceted; they come from diverse brain areas and are integrated at different loci in neural circuits. What type of information they carry and where is still unclear despite their fundamental role in shaping even the most mundane tasks.FeedbackCircuits will investigate the mechanistic circuit basis of feedback-driven cortical computations, including contextual modulation and the amplification of unexpected stimuli, and will pinpoint the synaptic plasticity mechanisms governing the wiring logic of feedback projections. Constrained by experimental data from the mouse visual cortex, I will build a multi-scale theoretical framework that unifies diverse experimental findings and links cellular to circuit-level processing. Our strategy leverages new datasets that encompass multiple modalities, from neural responses in various brain regions to detailed synaptic-level wiring diagrams. The proposed mechanistic models will enable the exploration of distinct feedback sources and sites of plasticity, and together with the data, define plausible parameter spaces underlying feedback-driven computations. In contrast to other efforts training hard-to-interpret artificial neural networks, our models promise to elucidate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ferroelectric Nanocomposites for Enhanced Solar Energy Efficiency' under Horizon 2020.

assistant: **Concept**

Solar photovoltaics (PVs) and sustainable fuel production from photocatalysis are key technologies to displacing fossil fuel use. However, in order to drive rapid growth in PVs, and the commercial viability of photocatalytic solar fuel production, innovative technological approaches are needed to increase efficiencies while keeping costs low.FENCES aims to demonstrate a new mechanism for solar energy conversion and use this to drive up the efficiencies of these key technologies. This will draw on a phenomenon found in ferroelectrics, known as the bulk photovoltaic (BPV) effect. While this has demonstrated photovoltages above the theoretical limit for conventional PVs, efficiency has remained low due to poor light absorption and charge transport. FENCES will overcome these limitations by intimately combining ferroelectrics and photoactive materials in nanocomposite thin films. This will couple the high electric field from the ferroelectric to the photoactive material, demonstrating novel behaviour with the potential to exceed the performance of current technologies.In order to achieve this, FENCES will:1. Design and synthesise optimal ferroelectric nanostructures and gain control over their properties, including the BPV effect, through careful study and tuning of the material properties in both precision model systems and low-cost, solution-based materials;2. Develop detailed device models to accurately describe and predict the behaviour of these novel devices, incorporating progressive knowledge and understanding throughout the project using both empirical data and computational modelling;3. Use these models to predict the optimum materials, structures and designs to demonstrate this novel technology and optimise device performance;4. Fabricate and test proof-of-concept
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Plasma reconfigurable metasurface technologies'.

assistant: **Innovation**

PULSE pursues the ambitious goal of defining a new technological horizon for implementing reconfigurable electromagnetic devices by unifying the research domains of metasurfaces with the plasma physics. The advantages retuned by plasma when combined with metasurfaces are multiple: first, plasma allows overcoming the main limitations of conventional reconfigurability strategies and achieving unprecedented tunability rate at high frequencies. Additionally, plasma enables conceptually new scenarios in which the individual properties of the meta-atoms, and even their shape/size, can be time-modulated. The project, thus, is aimed to fully merging two different research fields for establishing a radically new technology (plasma metadevices) offering unprecedented possibilities. To address this vision, several science-to-technology breakthroughs are proposed, including tunable lenses for antennas, non-reciprocal devices in waveguide technology and four-dimensional (4D) devices, in which the variation of the shape over the time becomes an additional degree of freedom to achieve new effects at the fundamental level. PULSE's technological goals are beyond the state-of-the-art and outside any scientific and technological roadmap of the involved scientific communities. In addition, it is expected that PULSE will also have a dramatic economic and society impact. The unprecedented functionalities of the plasma-based metadevices, in fact, can address the increasingly stringent requirements of the next-generation telecommunication systems. To achieve PULSE's ambitious scopes, the Consortium has been built for success in terms of industry and academic excellence. We have brought together a Consortium with a true European dimension, with eigth beneficiaries from Italy, Spain, Finland, Gr