RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Elucidating the role of the protein STING in innate immunity to DNA and intracellular pathogens' under Seventh Framework.

assistant: **Concept**

Infectious diseases kill 16 million people world-wide each year. Understanding how the immune system functions to sense and fight pathogens is essential for improving human health. A key host response to infection is the production of type I interferons (IFN). STING (Stimulator of IFN Genes) is a protein proposed to be essential for host type I IFN production in response to various intracellular pathogens including DNA and RNA viruses and bacteria. The reasons that STING may be involved in host defence against such a broad spectrum of pathogens is that STING is a critical player in the signalling pathway activated by cytosolic sensing of viral and bacterial DNA leading to type I IFN induction. Studies done in STING-deficient mice have demonstrated that STING is essential for host defence against viral infections. However the in vivo role of STING in intracellular bacterial pathogen infections is not clear. Moreover, it is not completely understood how and where STING activates type I IFN production in the cell. In this proposal, the Fellow will adopt biochemical and cell biology approaches to define the STING-mediated DNA sensing signalling pathway as well as the intracellular location(s) where signalling takes place (Objective A). The Fellow will use a conditional STING-deficient mouse that he recently generated to study the in vivo role of STING in host defence against intracellular pathogen infections (Objective B). This proposal is designed to utilize the strengths of both the Fellow and the Host lab to facilitate mutual transfer of knowledge and expertise for both parties. The host lab has a strong interest in studying the role of STING in sensing pathogen DNA, and the Fellow will provide the expertise and tools to allow these studies to bear fruit. In turn, the Fe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'COLOPHONS AND SCHOLARS: TOWARDS A SOCIAL HISTORY OF KNOWLEDGE IN BABYLONIA DURING THE FIRST MILLENNIUM BCE' (Colophons-Scholars), addressing dissemination and exploitation.

assistant: **Impact**

My Colophons and Scholars project will undertake an infrastructural intervention into the history and sociology of science urgently required for the one of the longest-living traditions of learning. It will open a major new data set and exploit it for evidence on the production, consumption, and transmission of knowledge in Babylonia. Why are colophons important? The entire lives of scribes, keepers of knowledge, can be traced through the colophons appended at the bottom of their works. As paratexts they offer a hitherto untapped opportunity of understanding the social context of the transmission of knowledge.I will change the state-of-the-art by offering a systematic study of all Neo-Babylonian colophons. Creating an online relational and GIS database and analyzing the colophon data will improve our understanding of Mesopotamian knowledge and give a new impulse for further study. My method combines the approaches of social networks analysis (SNA) with those of the sociology of science, anthropology, archaeology, economic history, and philology. The project will be supervised at Leiden University by Prof. Waerzeggers, the first Assyriologist to adopt SNA for studying Babylonian cuneiform records. It will collaborate closely with her ERC project Persia and Babylonia. Access to the specialist library and cuneiform tablets of the Netherlands Institute of the Near East in Leiden, and working within the multidisciplinary structure of the Leiden Institute of Area Studies offers an ideal environment for conducting my research and disseminating my results. This will be achieved by providing an open access database, publishing a monograph, and organizing  international seminars. I expect to acquire proficiency in consulting Neo-Babylonian archives and refine my theoretical train
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Silicon Photonics Transceiver and Routing technologies for High-End Multi-Socket Server Blades with Tb/s Throughput interconnect  interfaces' under Horizon 2020.

assistant: **Concept**

The overall objective of STREAMS is to develop the necessary Silicon Photonics Transceiver and Routing technologies towards a new, power efficient, WDM-based, Tb/s, optical on-board interconnection paradigm that enables multiple high bandwidth, point-to-point direct links on the board level, as a step forward to the realization of exa-scale computing systems. Through the migration of successful WDM networking practices to the mid-plane computercom level, STREAMS will develop a distributed routing system based on a passive Si-Pho AWGR routing element to provide simultaneous any-to-any communication between 16 end-points, such as high-end processor sockets.  STREAMS will also develop a novel DWDM, software controlled, Si-Pho embedded optical modules to interface each socket CPU with the WDM routing platform, in order to guarantee successful wavelength routing and interconnection of CPUs by correctly correlating the data to the designated transmission wavelengths. STREAMS optical engine will exhibit 1.6 Tb/s throughput with 50 Gb/s line rate over 32 wavelength channels, enabling a massive any-to-any, buffer-less, collision-less and extremely low latency routing platform with 25.6Tb/s aggregate throughput. The proposed STREAMS distributed routing system allows maximum granularity of the network resources and their optimal allocation with energy saving criteria. Finally, STREAMS will develop a single-mode polymer based electro optical-PCB to host the WDM-based optical engine and router modules to form a complete power efficient, cost-effective high-speed Optical Path Interconnect for multiple end-point mid-board systems that will outperform current state-of-the-art multi-socket server blades technology by an order of magnitude in aggregated throughput and link power efficien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development and commercial production of standardized PCR-assays for detection of hemorrhagic fever viruses and variola virus and their implementation in the diagnostic service of EU P4 laboratories' under Sixth Framework.

assistant: **Concept**

The main objective of the project is the development and distribution of a set of high-quality, standardized, and evaluated PCR-based detection methods for variola virus and viruses causing hemorrhagic fever (VHP; Ebola virus, Marburg virus, Lassa virus and related South American arenaviruses, and CCHF virus). The implementation of these assays in the diagnostic service of all existing European P4 laboratories will establish a laboratory infrastructure that can provide high quality diagnostic services to all Member States. Furthermore, in order to facilitate wide distribution and safe handling of PCR assays for the most relevant viruses (variola virus, Ebola and Marburg viruses, Lassa virus, and CCHF virus), the assays will be produced by a company (SME) as ready-to-use kits. These assays are intended as a rapid first-line diagnostic tool. They will also be made available to experienced laboratories in Member States, for example those of the European Network of Imported Viral Diseases (ENIVD), which do not have direct access to P4 facilities. A different set of PCR assays shall be developed for confirmatory testing. These are not produced as a kit and are to be used mainly by the P4 laboratories. The development of the PCR assays requires the concerted action of all European laboratories experienced in handling and diagnosing VHF and pox viruses as well as of a company experienced in developing and producing PCR kits for infectious agents. The project is based on pooling of the resources available in all P4 laboratories (technologies, virus strains, human and animal samples) to optimise and evaluate the PCR assays. Great attention is paid to demonstration activities and inter-laboratory quality control measures to ensure that the novel technologies arising from the proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Process Improvement Explorer: Automated Discovery and Assessment of Business Process Improvement Opportunities' (PIX).

assistant: **Concept**

Business processes are the operational backbone of modern organizations. Their continuous improvement is key to the achievement of business objectives, be it with respect to efficiency, quality, compliance, or agility. Accordingly, a common task for process analysts is to discover and assess process improvement opportunities, i.e. changes to one or more processes, which are likely to improve them with respect to one or more performance measures. Current approaches to discover process improvement opportunities are expert-driven. In these approaches, data are used to assess opportunities derived from experience and intuition rather than to discover them in the first place. Moreover, as the assessment of opportunities is manual, analysts can only explore a fraction thereof. PIX will build the foundations of a new generation of process improvement methods that do not exclusively rely on guidelines and heuristics, but rather on a systematic exploration of a space of possible changes derived from process execution data. Specifically, PIX will develop conceptual frameworks and algorithms to analyze process execution data in order to discover process changes corresponding to possible improvement opportunities, including changes in the control-flow dependencies between activities, partial automation of activities, changes in resource allocation rules, or changes in decision rules that may reduce wastes or negative outcomes. Each change will be associated with a multi-dimensional utility, thus allowing us to map a process improvement problem to an optimization problem over a multidimensional space. Given this mapping, PIX will develop efficient and incremental methods to search through said spaces in order to find Pareto-optimal groups of changes. The outputs will be embodied in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Numeric simulation of magnetic properties of molecular magnets and high-spinclusters using the Monte Carlo metropolis methode' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content The goal of the project is to simulate magnetic properties of complex systems like molecular based magnets or high-spin clusters by Monte Carlo Calculation. In a first place the simulation will concern magnetic clusters and 2D or 3D compounds based on spins S=2 or 5/2.A considerable ammount of this type of compounds are known in the litterature and some of them have been prepared in our laboratory. For these systems we propose to use classical Monte Carlo calculations to derive the amplitude of interaction between the magnetic centers. Secondly, systems containing spins S=1/2,1 and 3/2 will be studied. In this case the spins have to be treated as quantum spin. Here we propose to use Quantum Monte Carlo method to elucidate the magnetic properties of these systems. Training content (objective, benefit and expected impact) The knowledge of Monte Carlo methods to simulate physical properties will be complementary to my formation in theoritical chemistry during my Ph D thesis. This method of calculation will allow me to interpret the physical properties of extended network and high nuclearity clusters synthesized in the Inorganic Chemistry Department of University of Valencia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dynamic aspects of biodiversity management of Quinoa' (QUINOA).

assistant: **Innovation**

Traditional agricultural selection and domestication practices have generated rich and original intra-specific diversity. Farming systems in developing countries integrate this diversity of species and varieties to cope with the variability of the lands farmed. In response to global change, the project focuses on the definition and implementation of management practices adapted to dynamic in situ preservation of genetic resources. It aims at identifying new  practices of managing varietal diversity based on interaction at different levels of farmer, commercial, and institutional seed systems. The project addresses in the field on in situ conservation of traditional cereal diversity. Its framework is focusing on the re-emergence in Chile of Quinoa using ex situ collections. The proposed methodology is based on the joint  construction of innovative tools - multi-agent models - capable of integrating the points of view of different stakeholders and then simulating the dynamic aspects of biodiversity management in order to analyze the impact of future developments. France and Italy have developed researches on Quinoa with Chile separately and the IRSES proposal is an opportunity to enforce coordination within E. U. to achieve jointly common objectives for in situ biodiversity conservation within a better understanding of nutritional and genetic properties of Quinoa that can be recognized by European markets. These exchanges will benefit to each partners interested in the importance of Quinoa for food security with a safety  approach. CIRAD in France (partner 1) is interested in modelling seed system to increase complementarities between actors involved into in situ and ex situ conservation. Chile is an example for us with different forms of seedbank including some open to f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LAND-use based MitigAtion for Resilient Climate pathways' (LANDMARC).

assistant: **Concept**

Roughly 30% of Nationally Determined Contributions (NDCs) under the Paris Agreement (PA) include land-based mitigation measures, but there are still significant uncertainties in their effectiveness to deliver negative emissions. Aside from the expected shortfall of all current NDCs to deliver on the below 2 oC ambition, this uncertainty adds to the risks to human wellbeing as a result of climate change. Land-use based mitigation technologies (LMTs) can play a crucial role in the global efforts to meet the PA goals and the Sustainable Development Goals (SDGs). Considering the land-climate-development interface, LANDMARC aims to assess the impacts of LMTs as net sinks for greenhouse gas (GHGs) by applying unique mixed-methods approach. LANDMARC assesses the potential and feasibility of LMTs in the AFOLU sector by: a) quantitatively assessing environmental, social-economic, co-benefits and trade-offs identified through a suite of monitoring tools and model system (including land use, climate and economic models) complemented by; b) qualitative assessments guided by stakeholder engagement. This mixed-method approach allows us to provide more detailed insights on the effectiveness and climate resilience of LMTs at different spatial scales (e.g. scaling up from local/national level to the regional/global level). These tools, services and approaches will contribute to land-based LMT decision support in the private sector and by policy makers. LANDMARC is an interdisciplinary consortium with expertise from ecology, engineering, climate sciences, global carbon cycle, soil sciences, satellite earth observation sciences, agronomy, economics, social sciences, and business. There is a balanced representation of partners from academia, SMEs, and NGOs from the EU, Africa, Asia and the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Building charge-MOSAIC nanofiltration membranes for removing micro-pollutants from surface and drinking water' in the context of a Horizon Europe call.

assistant: **Objectives**

Our surface and drinking water sources are increasingly threatened by the presence of organic micropollutants (OMPs). OMPs are small molecules (100-1000 Da) that originate from industrial, agricultural and pharmaceutical residues, and can cause long-term harm to humans and ecosystems. While OMPs can be removed from water with existing membrane technologies (e.g., reverse osmosis), these methods have significant limitations: they are energy-intensive and lead to problematic brine waste streams, due to their low water and salt permeability.In this project I aim to solve these limitations by building charge-mosaic membranes; membranes with small (nm2) oppositely charged patches that allow coupled passage of negative and positive ions. This design, aimed at reducing salt retention, was conceived over 90 years ago, but was never realized in a scalable manner due to its challenging design. Here, I propose a simple and fully scalable approach to achieve such membranes, using polyelectrolyte multilayers (PEMs) of oppositely charged polymers. I will build these charge-mosaic membranes using ultrathin, ultradense layers in an asymmetric PEM approach to achieve a very high   (> 99%) retention of OMPs and a high water permeability.Combined with state-of-the-art modelling, this project will also provide new fundamental insights into membrane mass transport. Moreover, the project will directly lead to membranes with unique separation properties, allowing the design of completely new processes to effectively remove OMPs from waste water and drinking water.ter.


**Keywords:** Polyelectrolyte multilayers, Nanofiltration, Contaminants of Emerging concern, Membrane Surface Science
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'A novel muscular micro-electro-stimulation device for the enhanced treatment of adolescent idiopathic scoliosis avoiding bracing and invasive open surgery'.

assistant: **Concept**

Adolescent idiopathic scoliosis (AIS) is a progressive structural spinal deformity that affects around 2-3% of children aged between 10 and 16 in the world. Current conservative treatments (bracing and physiotherapy) are not sufficiently effective in stopping curve progression, so that more than 40.000 patients per year need an invasive fusion surgery that eliminates spine mobility. Recent studies evidenced that the spine deformity is a musculoskeletal expression of a central nervous system disorder that affects the paraspinal muscles inducing an imbalance of forces acting over the vertebral segments. The results of these studies and the work of a renowned clinical research group participating in the project (UCV) constitute the basis for the StimulAIS project, whose main objective is the development of a novel device for the treatment of AIS by muscular electro-stimulation of the deep paraspinal rotator muscles. The novel system will provide a customized treatment protocol to each patient, with targeted stimulation and real time control to maintain stimulation effectiveness and maximize treatment outcome. This device will be capable of stopping progression of the curvature and of correcting it, avoiding the side effects of current solutions, reducing the rate of surgery, and being cost effective compared to the abovementioned methods. The consortium integrates three SMEs along the product value chain, experienced in manufacturing and distribution of medical devices, surgical instruments and electrotherapy systems. The core R&D activities will be carried out by UCV, and two more RTD centers, namely IBV and FRAUNHOFER-IPMS, who have the necessary capabilities to achieve the objectives through development, integration and validation stages. The expected potential market f