RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'System biology of nitrogen-carbon-signal integration in the overall Arabidopsis signaling network' (ATSYSTM-BIOL), addressing dissemination and exploitation.

assistant: **Impact**

Plant development is under the control of abiotic environment. Nitrogen (N) and Carbon (C) signaling are well known to interact together, but also with a set of diverse signaling pathways including light and the plant hormones, auxin or cytokinin. Relationships of C/N “balance” with these “growth factors” are hypothesized to trigger the regulation of broad developmental processes such as root/shoot development or flowering.  The overall aim of this proposal is to use a genomics and systems biology approach to design and explore an experimental space to test how the intersection of light, carbon, nitrogen and hormone signaling pathways acts to coordinate responses of gene networks in Arabidopsis. Combinatorial Design will be used to select a set of treatments designed to broadly cover the experimental space of interactions using a minimal number of treatments, as described in Lejay et al 2005, and whole genome responses will be assayed using Affymetrix Gene Chips. The work flow includes:  Aim 1.  Design and test the entire experimental space of treatments using reporter gene constructs, to aid in selection of an optimal CD set for transcriptome analysis. Aim 2.  Integrate & analyze transcriptomic data in the context of Arabidopsis multinetworks to identify regulatory gene networks whose expression is controlled by the interaction of these different signals on gene regulation. This analysis will allow us to identify “hub”-genes involved in coordinating gene network responses to N/C/Light/Hormones signals. Aim 3. Validate the gene regulatory networks by classical reverse-genetics concerning “hub”-gene and to place these molecular actors into previously identified gene networks. This project will mark a significant and useful turn in my scientific experience to genomics, bi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'LEAP home, a new home for a sustainable future. A functional and aesthetic answer to a liberated living.' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The aim of our project is to fully meet the new demands for energy sustainability and reduced environmental impact throughout a building's entire lifecycle as well as the emerging trends for a lifestyle more deeply steeped in nature. This will be achieved by supplying truly high-performance buildings. The offer will consist of kits: individual, customizable, pre-wired and furnished homes, that even including auxiliary internal outfitting. Innovative materials and production technologies, advanced building engineering processes for components and production using numerical control systems, will allow to obtain extremely high dimensional precision, thus making dry assembly of all components possible with a reduced use of polluting materials like mortars and  glues. Thanks to the the use of composite materials and of specific construction technologies, the weight of the building components will be limited and thus shipping, even over long distances, will be cheaper.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Understanding divisions and fostering dialogue among Berlin’s Turkish speaking communities' (ARAMIZDA) under Horizon Europe.

assistant: **Objectives**

After 60 years of migration in countless waves, Germany’s Turkish-speaking communities are complex and diverse. Routinely lumped together by policymakers, media and the public as “Turks”, they in fact encompass a multitude of ethnicities, religions, classes and political groupings. Though they live side-by-side, they often have little contact and frequently harbour disparaging, even hostile feelings towards each other. ARAMIZDA (meaning “between/among us” in Turkish), draws on methods and theories from a range of disciplines to produce novel, high-quality research on divisions within Berlin’s Turkish-speaking communities. It explores the role civil society organisations play in easing and exacerbating those divides. Previous work on Europe’s large Turkish-speaking diasporas (including Kurds) has been mostly concerned with these groups’ links to Turkey or their integration with host populations. No detailed study has focused explicitly on how they interact with each other. At a time when European policymakers are grappling with the paradox of growing spaces for minority communities but shrinking opportunities for social dialogue, the project will use a mix of social science methods (including ethnographic fieldwork, diaries and interviews) to collect rich data to understand divisions within Turkish-speaking communities. It will foster collaboration with research participants by inviting them to play a role in determining data collection methods and taking an active role in a key non-academic offshoot of the project. This final aspect will take the form of workshop, run in partnership with an anti-polarisation charity, aimed at piloting ways of encouraging diverse groups to engage in dialogue. The findings — which will be widely dispersed through academic and non-academic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Marie Curie summer schools on the human dimensions of global environmental change' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The applicants propose a series of four Marie Curie Summer Schools on the Human Dimensions of Global Environmental Change. The summer schools would be held back-to-back with the annual European Conferences on the Human Dimensions of Global Environmental Change (European Conferences), which are endorsed by the International Human Dimensions Programme on Global Environmental Change (IHDP), as well as by major European research programmes. Combining the Summer School series with the European Conferences will benefit European researchers in their early career stages, by enabling them to participate in a conference series of international reputation (through a contribution to participant fees) and by ensuring a high level of quality of lecturers (because keynote speakers and other senior conference speakers can be recruited to give lectures at the Summer School).The summer schools would occur annually over the period from 2007 to 2010. Each summer school will be ten days' duration and bring together about 40 young European researchers. The four summer schools will form a consistent and coherent programme of four training events under the overall theme of earth system governance. This theme has been chosen to reflect both the current state of discussion in the field of human dimensions of global environmental change, and the recent attempts at integrating social and natural science research in this field.This integration stands at the centre of comprehensive models of earth system analysis and sustainability science, which try to bring together most academic disciplines at multiple spatial and temporal scales. To educate and train young European social scientists to participate in these global debates and to shape the future European contribution in the social sciences to thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Exploring inflammasome activation and targeted inhibition'.

assistant: **Innovation**

Inflammasomes are cytosolic multi-protein complexes that form in response to a wide range of pathogens, tissue damage, and other harmful stimuli. Members of the family of NOD-like receptors (NLRs) sense these pathogen and danger associated molecular patterns, triggering innate immune responses. NLRP3 is a well-studied NLR whose activation by a broad spectrum of stimuli leads to inflammasome formation and pyroptosis. Yet, the mechanisms inducing NLRP3 activation and the way how antagonistic small molecules counteract its function remain poorly understood. Just recently, we have determined the cryo-electron microscopy structures of full-length human NLRP3 in its inactive form and bound to the inhibitor CRID3. Native NLRP3 is a decamer composed of homodimers of intertwined LRR domains that assemble back-to-back as pentamers. We made the surprising finding that the effector pyrin domain is shielded inside the decamer cage providing a safeguard mechanism against accidental activation. To obtain insights into the activation mechanism of NLRP3 and the molecular formation of the inflammasome, I here propose a challenging and pioneering endeavour: employing biochemical, biophysical and structural analyses, we will resolve the structure of activated NLRP3 associated to lipid membranes, unravel its regulation by post-translational modifications, design specific inhibitors for the targeted protein degradation, and explore filamentous seeds for the maturation of Caspase-1 and Alzheimer’s disease forming amyloid-beta fibrils. Further, transferring our knowledge of CRID3-mediated NLRP3 inhibition to other NLRs as NLRP12 and NLRP1 will shed light on their mechanism of action and open new avenues for directed targeting. Collectively, this work will uncover fundamental molecular principl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Complex adaptation in photosynthetic microbes evolving in response to global change'.

assistant: **Innovation**

Microbes evolve rapidly in changing environments, and global change may soon cause future microbial populations to differ genetically and phenotypically from contemporary populations. We have both pragmatic and intellectual interests in microbial evolution, especially when microbial communities perform important ecological services. For example, marine phytoplankton are responsible for half of global primary production, and make up the biological carbon sink in oceans. However, marine environments are changing in complex ways, and future global carbon and energy cycles may depend heavily on how phytoplankton evolve in response to global change.My research will study how photosynthetic microbes evolve in complex environments. First, I will use mathematical models and experimental evolution in a microalgal model system to compare phenotypic changes between populations that have evolved either in an environment where many variables change simultaneously, or in an environment where only one variable changes at a time. Second, I will use the same model system to study if and how heritable epigenetic change, such as methylation and miRNA regulation, affects long-term adaptation. Both sets of experiments will use environmental shifts that are associated with global change, thus providing information specific to marine phytoplankton evolution, as well as insight into fundamental evolutionary processes. Finally, I will use RAD sequening in natural algal isolates from high CO2 environments to map and produce a list of candidate loci that may have contributed to long-term evolution in elevated CO2. The results of this work will significantly improve our ability to use evolutionary theory to understand how microbes are likely to change over the coming decades.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Calibration of Astronomical Spectrographs with Stabilized Fabry-Perot Etalons' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The “holy grail” of exoplanet research today is the detection of an Earth-like planet in the habitable zone of a Sun-like star. Doppler spectroscopy is an indispensable tool for finding and characterizing extrasolar planets; however, detecting an Earth twin by measuring the radial velocity (RV) perturbation it imposes on the parent star requires nearly one order of magnitude better RV precision than the best current spectrographs provide. A key component in addressing the limitations of existing instruments is the development of extremely precise calibration light sources that can be used to track drifts and imperfections of the spectrograph, removing them from the science data. A stable, reliable, and relatively inexpensive calibrator solves a “chicken and egg” problem in the field – motivating the building of more stable spectrographs, secure in the knowledge that they will be able to perform to their potential. Project STABLE_FABRY consists of developing a novel calibration technique that can be applied to a wide range of high resolution spectrographs. This technique uses a broadband Fabry-Perot etalon to provide the calibration spectrum; the etalon is stabilized by referencing it to an atomic transition using standard laser spectroscopy methods. Our preliminary work already indicates that a stability of 3 cm/s can be reached with this method, making it precise enough for detection of Earth-like planets. The only other currently available calibration technology with demonstrated precision at that level is the laser frequency comb, which is an order of magnitude more complex and significantly more expensive. Our technique can easily be adapted to different echelle spectrographs in the visible and near infrared by simply using an etalon optimized for that particular sp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Contaminant analysis in Food by Liquid Chromatography Mass Spectrometry: towards a generic extraction and screening for pesticides and veterinary drugs'.

assistant: **Concept**

The presence of potentially hazardous pesticides and veterinary drugs in food remains a major concern among European consumers. It is important to monitor their residues to ensure that they are not found in food at levels presenting an unacceptable risk to humans. A variety of multiresidue analytical methods are used in official routine laboratories to help ensure the safety of food and feed in Europe. However, highly polar analytes cannot be usually included in these methods due to their different physic-chemical characteristics. Also, the number of residues routinely analyzed is limited and data are collected only for those targeted compounds, so other potentially harmful, non-targeted analytes or their metabolites are not detected although being present in the sample.The project’s general main goal will be the development of generic, faster and more cost-efficient multiresidue methods for the extraction and analysis in food samples of a wide range of pesticides and veterinary drugs, both target (focusing on highly polar problematic analytes) and non-target compounds (including metabolites), using state-of-the-art analytical equipment, i.e. liquid chromatography coupled to mass spectrometry. These methods will permit more food samples to be monitored due to the lower cost and time per test. In combination with the broadened spectrum of detectable contaminants and the additional safety provided for unexpected residues, the project will significantly increase food safety in Europe.The overall work will be carried out at the “Laboratory of Pharmaceutical Analytical Chemistry” (LCAP) at the University of Geneva, a long-experienced group in the development of methods for the analysis of drugs and metabolites with modern techniques. As part of collaboration, the developed m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Reliable Communication in Integrated Circuits'.

assistant: **Objectives**

Interconnects responsible for the communication between different parts of a microprocessor are a critical bottleneck in integrated circuits. Indeed, as circuit geometries become smaller, the cost of performing computation continues to decrease while the cost of on-chip communication is not improving. The conventional approach to address this bottleneck is to introduce new materials and refine manufacturing technology of integrated circuits so as to reduce performance limiting effects in interconnects. However, it is expected that to address long-term technology requirements of integrated circuits new design or technology solutions will be needed. One possible solution that addresses performance limitations of interconnects is to use signal coding techniques. Thus, instead of sending data directly from one part of a microprocessor to another, they are first encoded so as to protect them against physical disturbances. This has the advantage that current interconnect technology can be used. However, designing good coding techniques involves the optimization of numerous design parameters and is therefore a challenging task. The proposed project addresses the design of coding techniques for on-chip communication by studying interconnects from an information-theoretic perspective. The following objectives shall be pursued: to identify the main physical phenomena that limit interconnect performance and to propose a channel model; to determine the largest code rate that allows for reliable on-chip communication (information theorists refer to this rate as the channel capacity); and to provide design criteria for designing coding techniques that perform close to this rate. The conclusions that can be drawn from these analyses will help future integrated circuit designers to add
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Southern Ocean and Antarctic Climatic Phasing:Tephrochronological Correlation of Southern Ocean Marine Records and Antarctic Ice-cores' (SHARP).

assistant: **Innovation**

Determining the temporal relationships of large-scale atmospheric and oceanic fluctuations is crucial for advancing understanding of the mechanisms controlling heat transfer between the Northern and Southern Hemispheres. The thermal bipolar see-saw caused asynchronous interhemispheric climatic changes during the last glacial period and Southern Ocean marine records and the Antarctic ice-cores are valuable archives recording this past climatic variability. Ascertaining the precise phasing of the climatic variability between these records provides crucial boundary conditions for testing models simulating the future behaviour of the bipolar see-saw and assessing potential large-scale oceanic and atmospheric reorganisations under anthropogenic forcing. In addition, establishing tighter constraints on phase relationships between sedimentary evidence for deep-water ventilation of CO2, and ice-core evidence for past atmospheric CO2 variations is key to determining the future response of the Earth system to rising CO2 levels. This project will address this challenge by ascertaining the rate, timing and phasing of Southern Hemisphere climatic changes between 40-10 kyr BP using tephrochronology to independently synchronise the palaeoclimatic sequences using common horizons of volcanic ash as time-synchronous tie-lines. Recognition of ash horizons not visible upon core inspection (cryptotephras) within sequences increasingly distal from volcanic regions has increased the scope of this technique. Cryptotephra identification methods will be used to trace ash horizons visible in Antarctic ice-cores into a marine core network from the Southern Ocean Atlantic sector and to trace previously unknown horizons identified in the marine realm into the Antarctic Atlantic sector EPICA DML ice-