RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'CHECKPOINTS IN CHECK: Novel Chemical Toolbox for Local Cancer Immunotherapy' to be submitted under Horizon 2020.

assistant: **Abstract**

Cancer evades the immune system by generating an immunosuppressive tumour-microenvironment through various mechanisms to enable unhampered growth. Recent breakthroughs in blocking one of these mechanisms – the so called ‘immune checkpoints’ – put cancer immunotherapy back in the spotlights. Although promising, clinical benefits of these checkpoint inhibitors as single treatment has been limited to a subset of patients and goes along with unwanted systemic autoimmune toxicity. I hypostasize, that attacking the tumour microenvironment from multiple immunological angles simultaneously by local, conditional, and multimodal immunomodulation will greatly improve success of cancer immunotherapy and patient wellbeing. To achieve this, I will develop a highly defined synergistic chemistry-based molecular therapeutic toolbox to specifically attack cancer, acting on effector T cells, macrophages as well as tumour cells simultaneously. In this highly multidisciplinary endeavour I will (i) generate novel multifunctional dendritic cell targeted anti-cancer vaccines to ‘educate’ the patient’s immune system to recognise the tumour, (ii) I will develop conditional, targeted immune checkpoint inhibitors to release the immunosuppressive break specifically within the tumour microenvironment without the risk of autoimmunity and (iii) I will generate chemical tools to locally eliminate the tumour-associated macrophages to tear down a major immunosuppressive barrier. I will do so utilizing the novel ModimAb technology which I developed to obtain functionalized antibody fragments. These individual therapeutic tools will allow me and my research team to explore uncharted tumour immunological territories in vitro as well as in vivo, greatly advancing the field of cancer immunotherapy. But above
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Impact of continuous flow mechanical unloading on the failing human heart' to be submitted under Seventh Framework.

assistant: **Abstract**

Heart failure (HF) represents a major public health problem with high morbidity and mortality. Health care expenditure for HF exceeds those of all cancers and myocardial infarctions combined. We aim to investigate structural, cellular and molecular changes of the failing human heart before and after non-pulsatile,continuous flow,left ventricular assist devices (LVAD) - induced unloading and to correlate them with changes in myocardial function.Tissue analysis will focus on 3 key myocardial remodeling features (fibrosis, microvasculature/endothelium and cardiomyocyte hypertrophy) which appear to be mechanistically associated during the remodeling process that eventually leads to HF (“endothelial to mesenchymal transition”).This translational investigation will a)formulate a standardized approach to acquire and evaluate myocardial tissue data along with clinical and functional data in HF patients before and after mechanical unloading and b)establish a baseline for the basic biologic effects of continuous flow LVAD unloading on the function and structure of the failing human heart.We emphasize that two major outcomes are possible, and both are important. The first outcome is that we observe significant degree of improvement in myocardial function induced by non-pulsatile LVADs. In this case our study will provide the basis for identifying the hallmarks that are associated with unloading-induced recovery. The second possible outcome is that the unloading-induced myocardial recovery is minimal or rare. This would further encourage investigations that combine LVAD use with adjuvant therapies. Our results would provide the clinical, functional and pathologic baseline necessary for investigations of the impact of pharmacologic or cell-based or other advanced therapies added to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Foundations of Intergenerational Discounting' to be submitted under Seventh Framework.

assistant: **Abstract**

Decisions about climate change, pension systems and other long-term issues affect not only the present but also future generations. Among the difficult questions raised by such intergenerational decisions, the following stands out as particularly controversial: how can the method of time discounting be applied to intergenerational decisions? In an intergenerational context, time discounting is the method of weighting costs and benefits to future generations less than those to the present one. This method is widely employed in public policy decisions with a large time-scale. Famously, there is widespread disagreement about intergenerational discounting, in particular about its social scientific foundations and its conceptual and ethical justification. This project in the philosophy of economics seeks to develop sound foundations for intergenerational discounting by employing approaches in measurement theory from philosophy of science, such as the representational theory of measurement. The project asks what kind of qualitative concepts a discounting factor expresses and under which conditions it is well founded.The proposed research has four objectives. Firstly, the project will provide general axiomatic foundations for intergenerational discounting, outlining the conditions that have to be met in order to establish discounting factors. Secondly, the project will assess conceptual motivations for intergenerational discounting that have been put forward in the literature on the social discount rate on the basis of the general axiomatic foundations, such as those that appeal to pure time preference, uncertainty, and the growth rate. Thirdly, the project will examine to what extent a distinction between facts and values can be upheld in intergenerational discounting, determ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Digital creative tools for digital printing of smart fabrics' (CREATIF).

assistant: **Innovation**

CREATIF provides the CCI with a creative experience collaborative tool consisting of intuitive software design tools coupled to a digital dispenser printer allowing them to create bespoke smart fabrics by printing. The design tools consist of software to collaboratively design, layout, visualise and simulate smart fabrics which are then produced using a dispenser printer; conventional fabrics are functionalised by printing active electronic inks. 'Visualisation' and simulation will interact in the collaborative design process with the senses of sight (through a monitor image), hearing (through Skype and by the smart fabric function of sound emission from the PC speakers) and touch (through the use of touch screens for design and the simulation of the feel of the fabric and the feeling of being touched on a haptic PC screen). CREATIF offers to the CCI the ability to transform everyday fabrics into knowledge intensive smart fabric based creations incorporating a high level of intellectual creative content, by mass customisation of basic templates, or in one off designs. The consortium consists of a design software developer (G-Soft), a university specialised in fabric machine design (ITA), a university with world leading expertise in creating smart fabrics by printing (UoS), a creative design SME (Diffus), an SME, active in design-led buildingstructures and architecture (BASE), a large company active in architecture and creative design (ZHA) and an SME specialised in advanced inkjet printers (Ardeje). We demonstrate the creative experience tools use in a real environment by producing, within CREATIF, three advanced smart fabric prototypes (for interactive light emission, interactive colour change and sound emission/touch) and apply them in two applications relevant to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovative integrated energy efficiency solutions for railway rolling stock, rail infrastructure and train operation' (RAILENERGY) under Sixth Framework.

assistant: **Objectives**

Within this call of FP6, the railway industry elaborates the Railenergy Integrated Research Project to develop a holistic framework approach, new concepts and integrated solutions to improve energy efficiency in the railway domain under specific technical, operational, political and socio-economic constraints. The overall objective of Railenergy is to cut the energy consumption within an optimised railway system thus contributing to a reduction in the life cycle costs of railway operation and of CO2 emissions per seat/kilometre or tonne/kilometre. The project target is to achieve a 6% reduction in the specific energy consumption of the rail system by 2020, assuming that traffic volumes double in comparison with current figures. Within the time frame of 48 Months of project duration, the 28 consortium partners will deliver: -Relevant baseline figures and scenarios for selected reference systems -A system-based concept for modelling energy consumption -A common and standardised methodology to determine energy consumption by rail sub-systems and components in the development and procurement phases -An integrated simulation tool for energy consumption and LCC -An integrated railway energy efficiency management approach and decision support tool -Strategic energy efficiency targets for rolling stock, infrastructure and traffic management -An Energy Management Module which could provide the operator with a diagnostic of their complete installation -New validated energy efficiency-oriented railway technologies for trackside and on-board sub-systems and equipment, developed in compliance with the new integrated approach -Refined best practices for Railway Operators and Infrastructure Managers -Strategies for incentives, pricing, and policies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'i2factory- Disrupting integration platform: secure and easy integration without any programming or component installation' in the context of a Horizon 2020 call.

assistant: **Objectives**

CONTEXT: In an increasingly global economy, both information and information technology are of great significance to SMEs to increase their competitiveness, achieve their economic potential and internationalize. The transfer of this information between different platforms or applications is called integration and it’s a critical element for companies and organizations to survive.PROBLEM: Integration need to be done such a way as to reduce the administrative and IT burden while keeping costs low and fostering internationalization. up to the date integration is out of reach for most organizations because of its high cost and complexity:NEED: it is necessary to provide SMEs with integration solutions with an appropriate level of abstraction to allow connection of software applications in a secure and consistent in a cost-effective way.OBJECTIVE: demonstrate the technical and commercial feasibility of a security integration platform as a service (iPaaS). i2factory is a cost-efficient platform where organizations can develop all their integration projects and link functionalities between different systems and platforms as they like it when they like it, without any programming or component installation. To date, i2factory has invested Approx. € 1.5 M to release the first functional version of i2factory v1.0, which is currently tested in users. We estimate that a sum of 914 K is still needed to rapidly and effectively launch i2factory v2.0 innovative solution into the market. With the development of i2factory v2.0 we will allow our company to consolidate and expand its market in Europe.Phase 1 will include a to feasibility assessment to guarantee the technical and commercial viability and profitability of our project confirm a business plan for successful commercialisation of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Nonlinear Energy Sink Metamaterial Approaches for Flow-Induced Vibration Attenuation' (METASINK) under Horizon 2020.

assistant: **Objectives**

Flow-induced vibration can occur in many engineering systems and structures such as bridges, transmission lines, aircraft control surfaces, offshore structures, marine cables, and other hydrodynamic applications. A novel approach to attenuate such vibrations could be the application of mechanical metamaterials, which are artificial engineering materials having unique elastic wave propagation properties based on the existence of stop and pass bands originating from the material or geometric periodicity. Nonlinear energy sinks are having a wider frequency band of vibration attenuation than linear vibration absorbers due to strong nonlinear stiffness. This project aims at taking the functionality of metamaterials to the next level by performing the design, modeling and experimental aspects of advanced materials research by combining the features of a hysteretic nonlinear energy sink, energy harvesting, dissipation effects and tuning of metamaterial properties based on magnetorheological composite in the metamaterial subunit design. This, in turn, will give rise to a novel class of semi-active magnetorheologically tuned metamaterials (MTMs) for flow-induced wing flutter and pipeline vibration control using linear and nonlinear approaches for bandgap forming, vibration attenuation, and energy harvesting. The computational framework based on numerical and semi-numerical methods together with pseudo-arc continuation techniques will be developed to discover dispersion characteristics of linear models, and frequency-responses and bifurcation points of nonlinear models. Novel 3D printing techniques will be developed for the fabrication of MTMs with magnetorheological composite. Experiments will serve to validate mathematical models and identify parameters of the nonlinear MTM mod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Establishing European Production of Hydrogen from RenewAble energy and integration into an industrial environment' (EPHYRA).

assistant: **Concept**

EPHYRA will demonstrate the integration of a first-of-its-kind renewable hydrogen production facility at industrial scale in South-eastern Europe by employing an improved electrolysis technology, at a scale of 30 MW. The large-scale electrolysis will be integrated with industrial operations within MOH’s Corinth Refinery, one of the top refineries in Europe and the largest privately-owned industrial complex in Greece. It will be operated for at least 2 years under commercial conditions and will supply renewable hydrogen to the refinery’s processes and external end-users.The industrially integrated renewable hydrogen production will be developed around a circular economy, industrial symbiotic approach, as the electrolyser will be coupled with (i) renewable electricity production, (ii) renewable electricity storage, (iii) an innovative waste heat harvesting technology, (iv) water use environmental optimisation, (v) valorisation of produced oxygen in current MOH Refinery operations, (vi) a digital twin and (vii) a dedicated energy management system. EPHYRA will contribute to all electrolysis technology KPIs as detailed in Clean Hydrogen Partnership SRIA objectives. Therefore, the project will demonstrate its reliability for green hydrogen production at the lowest possible cost thus enabling the EU renewable hydrogen economy, industry decarbonisation and zero-emission fuels uptake.EPHYRA will be implemented by a strong consortium with robust research, innovation and industrial capabilities, able to successfully deliver the project within time, budget and detail objectives. The aim of EPHYRA is to enhance European synergies on the globally expanding hydrogen market and build a unique value proposition on industrial symbiotic renewable hydrogen production.


**Keywords:** Gree
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sharp Regularity Bounds of Maximal Functions' (SRMF) targeting Horizon Europe.

assistant: **Abstract**

In 1997 Juha Kinnunen proved that maximal operators satisfy a Sobolev bound if the Sobolev exponent p is strictly larger than 1. His article initiated the study of regularity of maximal functions, a field which has attracted several dozens of authors to this day. Geometric techniques have recently lead to a series of breakthrough endpoint regularity bounds for maximal operators in higher dimensions. This project pursues the novel strategy of combining these new geometric tools with already established extremization techniques in order to solve a wide range of open questions in the field.The goals of the project are organized around two themes: gradient bounds and sharp constants. The main goal from the first theme is to prove that the variation of the non-centered Hardy-Littlewood maximal function can be controlled by the variation of the function in all dimensions. This is the endpoint p=1 of Juha Kinnunen's original bound and is one of the main long standing open questions in the field. This project also aims to prove this variation bound for further maximal operators, along with the operator continuity of their gradient and bounds for higher derivatives.The main goal from the second theme is to prove that the centered Hardy-Littlewood maximal operator in one dimension does not increase the variation of a function. This bound would be sharp because examples show that in general, maximal operators do not strictly decrease the variation of a function. This project further aims to prove this sharp bound for convolution type maximal operators and to find the sharp constant in the variation bound for the dyadic maximal operator in all dimensions.


**Keywords:** maximal function, Sobolev space, variation, endpoint, extremization, sharp constant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Customised Advisory Services for Energy-efficient Manufacturing Systems'.

assistant: **Concept**

This CASES project is aimed at teaming up trans-continental researchers in the areas of sustainable design/manufacturing and ICT to enrich the knowledge base and achieve research synergies to develop smart design and manufacturing planning services in terms of energy efficiency. The objectives include:(1)To establish an active international community and effective communication channel for research teams from various regions of the EU, China and Ukraine to collaborate in the research area of eco-design and energy-efficient manufacturing planning.(2)To integrate the complementary expertise of the European, Chinese and Ukrainian teams to devise ICT-based smart services and standards to address the multi-faceted requirements of eco-design and sustainable manufacturing planning. Activities include:•The impact of globally sustainable trends on the current practices in the EU, China and Ukraine would be evaluated and  relevant strategies and best practices will be proposed;•Research in eco-design, manufacturing planning, cloud and service-oriented computing, and computational intelligence will be synchronised to develop innovative smart services.(3)To leverage the geographical characteristics of all teams for research evaluation, improvement and dissemination. The plan includes:•The smart services, acquired from the integration of research, systems and algorithms within the teams, will be deployed geographically dispersed for evaluation and improvement;•Knowledge sharing and outreach activities will be organised for relevant communities and stakeholders in the EU, China and Ukraine to increase the awareness of the proposed solutions to enable them to shift towards sustainability efficiently.