RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Improving Prostate Cancer Outcome with Vectored Vaccines' (IMPROVE) targeting Seventh Framework.

assistant: **Abstract**

A successful vaccine against cancer is most likely to work through the induction of potent CD8+ T cells that can successfully kill tumour cells. But achieving this has proved difficult and only low level responses are induced by current vaccine approaches. Nonetheless, two therapeutic immunisation strategies have shown partial success in targeting prostate cancer, and one recently reached licensure.Recently, advances in infectious disease vaccinology have identified an exceptionally potent heterologous prime-boost immunisation strategy that has repeatedly induced T cell responses far greater than those observed in cancer immunotherapy. We will test this simian adenovirus – MVA approach for the first time in cancer immunotherapy, targeting prostate tumours. We will use an MVA vector encoding the oncofetal antigen 5T4, that has been used safely already in over 500 patients. We will add a priming immunisation with a simian adenovirus aiming to enhance immunogenicity to therapeutic levels. We will use a new accelerated clinical trial design aiming to detect efficacy in relatively early stage prostate cancer patients, exploiting sensitive histological, biochemical and magnetic resonance imaging measures of vaccine efficacy. We will combine this with detailed immunomonitoring, quantitative analysis of immune effector cells in the prostate following immunotherapy treatment and assess a new predictor of vaccine performance.For the first time, we will evaluate whether checkpoint inhibitor treatment (PD-1 and PD-L1 monoclonal antibodies) can be clinically effective in prostate cancer if it is given in combination with antigen-specific immunotherapy and whether both early and late stage prostate cancer patients can be benefit from it. Tumour burden following immunisation will be m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Coordination of national research programmes in Agri-Food and biotechnology - Joining forces of ERA-Net Cofunds, EJP and self sustained initiatives' (2021-2027) under Horizon Europe.

assistant: **Objectives**

The Green ERA-Hub (GEH) represents 15 currently active EU ERA-Net Cofunds and self-sustained initiatives in the field of Agri-food and biotechnology. Together with already ended predecessor initiatives, they represent 29 co-ordination actions in which more than 1100 Mio Euro funding has been mobilised via 89 transnational calls. The ERA-Net scheme is a success model for transnational co-operation of national research programmes. The partners consider GEH an ideal measure to continue and extend this fruitful co-operation. The aims of GEH are to:- continue to build on previous achievements and further enhance cross-sector collaborations between Agri-food and biotechnology ERA-Nets, through joint transnational funding of collaborative research projects- valorise and implement joint activities supporting the market, regulatory or societal uptake of results after the end of individual ERA-Nets- identify common research and innovation priorities, agreed upon by the participating national programmes, and address them via new joint calls- preserve best practice and managerial competences- contribute to the planning and complement the implementation of the new HEU Partnerships and Missions- broaden the actions and impact of initiatives towards stakeholders and in terms of geographical coverage - contribute to achieve the strategic goals of the SDGs, in particular zero hunger, industry innovation and infrastructure, responsible consumption and production, life on land, partnership for the goals, the farm2fork strategy and EU's Green Deal.GEH will provide clear perspectives for ERA-Net (Cofunds), national research funders and researchers in the Agri-food and biotechnology sector to find dedicated support at the level of information, communication, co-operation, networking and join
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'OPTIMAL METHODS TO CHARACTERIZE ADC RESISTANCE IN SOLID TUMORS AND IDENTIFY CLINICALLY USEFUL BIOMARKERS'.

assistant: **Innovation**

Over the past 5 years, antibody drug conjugates (ADCs) have shown impressive improvements in survival outcomes of solid tumors and hematological malignancies. With 14 ADCs already approved across different countries and more than 140 that entered the clinical development, they are intended to replace standard chemotherapies across multiple tumor types over the next decade. Although ADCs show great clinical efficacy, resistance eventually occurs, and it becomes critical to understand resistance mechanisms to guide the choice of the following lines of therapy for patients who progress on a given ADC. Given the complex nature of ADCs, immunocompromised mouse models (nude mice, NOD-SCID or NOG mice) and currently used clinical assays (standard radiology, IHC, WES etc) are not the optimal preclinical and clinical tools, to identify the multiple causes of resistance. The OASIS project aims to generate a biobank of different patient-derived organoids (PDOs), which better recapitulate ADCs resistance and integrate different assays, spanning from whole-body molecular imaging (Ab-radiolabeled PET scan or immunoPET), circulating tumor cells (CTC), plasma proteomics, to multiplex immunofluorescence (MIF) and machine-learning enhanced digital pathology (AI-digital pathology) to capture most of the parallel mechanisms of resistance to ADCs. Such tools will enable to define biomarkers of ADC resistance that can inform further therapeutic decisions.


**Keywords:** Antidoby drug conjugates; Patient Derived Organoids; Ab-radiolabeled imaging; Circulating Tumor Cells; AI digital pathology; Proteomics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Nezam and Nazm: Iran's Concept of International Order'.

assistant: **Objectives**

The past, present, and future of the International Order are recurrent subjects of exploration and studies in International Relations, Middle East Studies, and History. Yet, most of such studies fail to grasp particularities and changes across time, space, and languages. In fact, International Order is traditionally discussed as an extension of the West or understood as a purely American-led phenomenon.  How can we talk and study international order without grasping particularities of the concept across different geographies and histories? Relying on a universal concept and the Eurocentric and Anglophile analyses of the international order undermine the agency of the non-Western states and societies,  obscures history,  and limits the scope of our knowledge production by focusing on just a few cases. Attempts to go beyond the West are also usually framed as a way to assess the risks to ‘Western’ order or policies.  By focusing on the case of Iran, this action challenges the assumption that 'International Order' has the same meaning across times, spaces, languages, and cultures. The action's state-of-the-art contributions to International Relations, conceptual history, and Middle East studies are manifested in its main objective to argue for investigating not just different conceptions of the international order but also analysing various usages of concepts to make sense of and order the international. The project asks how is international order conceptualised? Where does the order come from? What distinguishes a new order from an old order? It seeks to understand origins, conceptions, and evolutions of the international order at a time when the future of the order is being debated.  Through conceptual history, Iran's distinct language and religious discourse also enable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Secondary Pseudepigraphy: Claimed Apostolically-Connected Authors and the Reception of Early Christian Literature'.

assistant: **Objectives**

The CLAIM Project studies the late antique and medieval practice of assigning an apostolic connection to a series of writings composed under the name of early Christian characters like Dionysius the Areopagite, Clement of Rome, Ignatius of Antioch and others, thought to have met central apostolic figures like Paul, Peter, or John. Unlike similar apocryphal works (attributed to the apostles themselves and implicitly claiming their direct authority), this broadly transmitted literature draws on a mediated type of authority and offering its own brand of derived access to idealised early Christian pasts. Aiming to offer a new approach to the history of Christian literature in late antiquity and middle ages and challenging the received idea that late antique and medieval Christians in idealised pasts turned to the apostles only (from the New Testament or apocryphal accounts), the CLAIM Project will explore the reception-historical dynamics of this type of secondary pseudepigraphy around the Mediterranean space, in five key late antique and medieval manuscript cultures: Greek, Coptic, Latin, Syriac, and Armenian. This investigation breaks new ground by challenging the received categories for late antique Christian literature currently in use in modern scholarship (including gender-based ones), and by integrating comparative manuscript studies with cultural history.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of innovative welding systems for structural joints of Thermoplastic matrix-based Composites' in the context of a Horizon 2020 call.

assistant: **Objectives**

DEWTECOMP project proposal objective will be To develop an induction welding system to achieve innovative and efficient way of structural bond of reinforcement parts (gussets, wedges, fittings) to structural frames to obtain a highly integrated Door Surround Structure (DSS), as well as to be able to weld assembly clips on stiffened panel.In order to achieve the main foreseen objective and system characteristics DEWTECOMP project will:-Provide at the beginning of the project a comparison of the state-of-the-art welding technologies (i.e. Laser, Induction, Conduction, Resistance and Ultrasonic welding-but not limited to them) with a benchmark of maturity to justify the use of Induction welding CETMA patented technology vs baseline resistance welding.-Propose and manufacture the most suitable and innovative system design for the induction welding technology to be applied for DSS, including supporting tools, automated devices, heating systems, end effectors required to weld DSS frames to DSS fittings and clamping methods to ensure welding surfaces contact. The induction welding system will be based on CETMA patented technology.-Generate process parameters in such a way that delivers the relevant information to Topic Manager but keeps the industrial secret that will be part of the exploitation plan of the consortia. For instance welding parameters (temperatures, speeds, pressures, tolerances…) as well as the tooling list and materials required will be provided to Topic Manager.-Manufacture and test coupons to validate the equipment and tooling. -Delivery of the Prototype System and tooling set for manufacturing to the Topic Manager facilities . -Carry on different manufacturing trials in order to proof the welding system characteristicsSupport set up in the Topic Manager pre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'International symposium om enterococci in foods. functional and safety aspects""' (ENTISYMPOSIUM).

assistant: **Innovation**

All partners involved in the Project FAIR-CT97-3078 Enterococci in Food Fermentations. Functionalism Safety Aspects", in collaboration with the Federal Institute for Health Protection of Consumers and Veterinary Medicine (Bevy, Germany), will organise an International Symposium on "Enterococci infolds. Functional and Safety Aspects". This conference aims to present the positive items of enterococci as food fomenters and robotics, and confront them with disadvantages such as potentialvirulence factors, antibiotic resistance development and spreading. The Symposium will focus on topics such as :-Ecology, Taxonomy and Physiology of Enterococci-Functionality of Enterococci in Foods-Functionality of Enterococci in the GI Tract-Safety Aspects of Enterococci"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'NEXT Low Power Magnetic Random Access Memory with Optimised Writing Time and Level of Integration.' in the context of a Fifth Framework call.

assistant: **Objectives**

Important discoveries have enlightened a strong competitor to existing RAM which is Magnetic RAM (MRAM). Instead of using electric charges as data storage (like it is done in all kinds of RAM, even NVRAM), MRAM are using cells which magnetic state can be reversed, like in Hard Disk drives, so as to store '0' and '1' with the difference that memory is Randomly Accessed, increasing drastically data transfer rates. Based on a recent advance in the magnetism field and in order to overcome the current difficulties, the consortium will investigate two different, new, promising writing processes: the Current Induced Magnetic Switching (CIMS) and the Thermally Assisted Switching (TAS).The objective of the project is therefore to perform scientific investigation allowing either one or the other technique to result in a fully operational 1Mbit prototype which performances would be: R/W cycle < 30ns and Power consumption < 5mW for one write cycle of 256 bits.DESCRIPTION OF WORKIn the project timeframe, the work will be divided in three actions:1. Development of materials and structures for TAS and CIMS operation with the aim of reducing the writing energy. The current density to be flowed during the writing step should be compatible with the use of magnetic tunnel junctions (MTJs). In parallel, all technological issues for the integration of the magnetic structures will be worked out: etching techniques (reactive ion etching or ion beam etching) for magnetic stack, integration of damascene interconnections with low surface roughness, cross compatibility between CMOS and magnetic tunnel junctions in terms of process conditions and temperature history.2. Demonstration of single operating cells using TAS or CIMS mode for electrical performance evaluation (R/W access time, R/W consump
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Supporting the Just transition for the Fashion sector' (2021-2027).

assistant: **Concept**

“Just Fashion”, is set to develop a portfolio of approaches to support and accelerate climate transition in the fashion industry, by providing businesses in the partner countries with a reference framework and tools to shift their production methods, internal proceduresand final products towards more sustainable models that are lower carbon, circular and socially inclusive.Just Fashion aims to address this problem by (1) mapping the current state of fashion and sustainability in Europe, (2) mapping and evaluating tools and on circular business models(3) create a process of interventions to support these tools and support existing networks in preparing MSMEs and SMEs for the new legislation on the European Green deal.4 central elements of the projects:1) Development of a new sustainability index as well as testing and refining several circular business model tools that are already in use in different areas and are already being tested in these countries.2) Run 6 pilot cases from different regions focussing on different aspects of circularity (end of life, materials, zero waste prototyping, circular business models, recycling techniques, transparency/traceability, ...).3) Update current instruments and tools in transformation & mitigation 4) Develop the necessary instruments to better prepare (M)SME's for European Green deals in terms of policy regulations (through buidling an AI support tool).


**Keywords:** Fashion, circularity, business models, sustainability
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Adenovirus Vector Technology: Next Generation Systems for Medical Therapy' to be submitted under Seventh Framework.

assistant: **Abstract**

We propose a programme (AD-VEC) involving two industrial and three academic partners with the aim to identify new adenoviral vectors as vehicles in novel medical applications for cardiovascular disease and infectious disease.This will be achieved through broad knowledge exchange between partners with complimentary and cutting edge technological and in-depth skills relating to adenovirus phylogeny, biology and pathology in order to explore and exploit adenovirus existing in nature as new vectors in areas of unmet clinical need such as cardiovascular disease and infectious disease. Our major objectives of AD-VEC are:(1) The provision of adenovirus genomes from novel rare human and non-human adenoviruses and engineering of these genomes to develop high quality recombinant adenovirus vectors expressing reporter genes;(2). To provide detailed evaluation of novel adenovirus vectors with respect to infectivity, receptor usage, tropism, and the interaction with the blood and immune system;(3). To evaluate these novel vectors at the pre-clinical level in areas of unmet clinical need, both using in vitro and in vivo studies.These three key objectives will enable excellence in adenovirus research amongst the AD-VEC consortium members through creating a synergistic and unique opportunity in this research field. The synergies are those that cross academic and industrial boundaries and create access to a pipeline of activity that will include basic virology, new assay development, novel preclinical models, pre-clinical manufacture and vector testing. This provides empowerment to the research teams through synergistic industry/academia collaborations developed towards a common goal, i.e. exploiting adenoviruses for medical therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Using evolution to uncover the importance of alternative pre mRNA splicing' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

A major mystery of the genome age is why complex and simple organisms all have a similar number of genes. My specialism is in ‘Alternative Splicing’ which is the means by which different products can be made from a single gene by differential incorporation of regions of pre-mRNA. Alternative splicing is therefore a mechanism to increase gene complexity in complex organisms like man and in complex tissues like the brain. Alternative splicing has since been shown to be a pervasive mechanism crucial to normal health and development. For two decades labs studied alternative splicing on a gene-by-gene basis. In the last ten years genomewide data has increased the number of known alternative events, and recent developments have found that at least 80% of genes produce alternative mRNAs. The major questions in the field currently concern which of these alternative splices are important, and the problem remains of how to answer this using a huge amount of data. The key innovation of this application is to use an evolutionary approach to identify the important alternative splices using a unique high throughput RT-PCR approach. The proposed project will involve collaboration with biological experts in Newcastle studying brain, muscle and stem cells, with an expert on evolution in France (Dr. Philippe Fort) and with the genomics platform (for which I worked for three years) in Quebec, Canada.