RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'GENeric European Sustainable Information Space for Environment' (GENESIS) targeting Seventh Framework.

assistant: **Abstract**

The GENESIS Project has the objective of providing Environment management and Health actors with an innovative solution based on advanced ICT. Relying on interoperability standards and harmonization process, GENESIS helps to constitute complex information networks, by combining benefits of various information systems with a collaborative systems approach. The proposed generic solution allows easy deployment and customization to thematic needs on a wide range of applications, at regional, national or Europe levels for various thematic fields. The main benefits of GENESIS solution are two-fold :-to improve and facilitate actors daily practices in relation with the management of environmental data; -to perform an essential step in the deployment of the Single Information Space for the environment in Europe. The GENESIS solution will be validated through dedicated scenarios addressing thematic fields of Air Quality, Water Quality and their impact on Health. For the final benefits and information of European citizens, the needs of Environment and Health stakeholders are covered through fundamental services like : -environment monitoring,<br/>-multi-criteria finding of the information; -visualization and combination of static or near-real-time information; -fusion of various sources of environmental data; -correlation between environmental with health data; -support of decision making processes; -support of the risk management and response to crisis; -near-real-time information of citizens. The GENESIS generic solution is open and sustainable as based on de facto and emerging standards (OGC, OASIS, INSPIRE,...). Moreover, the GENESIS project development integrates current state of the art and innovative researches of major EC or ESA projects. GENERIS project represents an imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Reprogramming of somatic cells into organOids: patient-centred neurodevelopmental disease modelling from nascent induced pluripotency' (ReprOids) under Horizon Europe.

assistant: **Objectives**

Understanding the neurodevelopmental causes and mechanisms of the brain disease is challenging due to the limited access to the human brain tissues, the complexity of brain anatomy and the lack of accurate models to recapitulate human brain development. The convergence between induced pluripotent stem cell and organoid technology enable to recapitulate key features of early human neurodevelopment disease in vitro. However, the low efficiency, high cost and technical variability of generating induced pluripotent stem cells (hiPSC) and organoids make an impossible challenge to design a powered study for associating patient genotype to organoids’ in vitro phenotypes.  I will generate technology to produce human brain organoids from a selected patient in a robust, timely and seamless process and to capture - so far undetected - neurodevelopmental phenotypes. This will be obtained by combining reprogramming to nascent states of pluripotency with neurodevelopmental morphogenesis in three-dimension. Starting from a single nascent naive hiPSC, we will develop a process to form an epiblast cyst, then neuroepithelial cyst and forebrain organoid in continuous three-dimension process.   I will use this technology to investigate genetic and epigenetic modifications in the early phase of neural development of Fragile X Syndrome (FXS). We will generate brain organoids from large cohorts of FXS patients for: i) profiling the whole spectrum of in vitro phonotypes associated with the variety of patient’ genetic and epigenetic modifications; ii) revealing unexplored developmentally regulated mechanisms; iii) design a powered study to assess targeted therapeutic options in FXS.  ReprOids will allow the generation of human brain organoids from large cohorts of patients capturing in vitro th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Digital Repository Infrastructure Vision for European Research' (2007-2013) under Seventh Framework.

assistant: **Objectives**

DRIVER is a multi-phase effort whose vision and primary objective is to establish a cohesive, pan-European infrastructure of Digital Repositories, offering sophisticated functionality services to both researchers and the general public. The present proposal (`DRIVER Phase-II') aims to introduce key innovations compared to the original `DRIVER' project, while building on its results. The main novelties envisioned are: Establishment of a ``European Confederation of Digital Repositories'' as a strategic arm of DRIVER; Inclusion of Digital Repositories with non-textual or non-publication content, e.g., images, presentations, and possibly primary data; Construction of ``enhanced publications'', which combine interrelated information objects into a logical whole, e.g., publications coupled with relevant presentations and associated datasets; Provision of advanced functionality to address the requirements raised by the above innovations or to serve varied modes of scientists' research explorations. Additionally, DRIVER Phase-II moves from a test-bed to a production-quality infrastructure, expands the geographical coverage of Digital Repositories included in it, intensifies state-of-the-art and future-direction studies, and escalates dissemination, training, and community building activities. `DRIVER Phase-II' significantly broadens the horizons of the whole DRIVER endeavour regarding infrastructure operation, functionality innovation, and community relevance, and constitutes a major step on the way to the envisioned Knowledge Society.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'PROLIFERA - Proliferative Arrest and its Ecological Relevance as a Resource Allocation Strategy in Arabidopsis'.

assistant: **Objectives**

The study of heritable variation in ecologically relevant plant traits can lead to insights into evolutionary processes and to increased agricultural output. Resource allocation strategies in flowering plants are of great interest, from an ecological and agricultural point of view. As plants have a modular body plan, they often initiate reproductive organs sequentially and the maternal plant has to balance current and future expenditures on offspring to produce an optimal number of seeds. Control mechanisms exerted by reproductive structures over maternal growth have been observed in several plant species -amongst them important crops- and are termed “correlative controls”. Such  mechanisms might represent offspring begging strategies in plants, whereby offspring influences maternal resource allocation patterns. The molecular bases and ecological relevance of these control mechanisms are, however, unclear.The applicant aims to i) use state-of-the art molecular techniques to investigate correlative controls in an annual plant ii) isolate genetic variation in the strength of controls that offspring exerts over maternal growth ii) apply recently developed methods in ecological competition experiments to compare fitness parameters amongst offspring from genetic variants and examine genotype-environment interactions. This will provide an ecological context to formulate an evolutionary hypothesis concerning the adaptive value of correlative controls in plants.The interdisciplinary project will be implemented at the University of Zurich under supervision of Prof. Schmid, a world-renowned ecologist located at the Institute of Evolutionary Biology and Environmental Sciences. It will be co-supervised by Prof. Grossniklaus (Institute of Plant Biology), expert in plant reproductive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'FUELLING STARTUP VILLAGES WITH CIRCULAR BIOECONOMY STRATEGIES' in the context of a Horizon Europe call.

assistant: **Objectives**

FoodCoP is an innovative venture to enhance interregional collaboration among Startup Villages to ignite the transformation of food systems. At the heart of this initiative lies the challenge of aligning diverse stakeholder interests and catalysing sustainable growth through the principles of the circular bioeconomy. The project aims to deliver three main impacts: establishing a robust collaborative framework, fostering sustainable food system transformations, and enhancing knowledge and awareness of circular bioeconomy solutions among rural innovators. Methodologically, FoodCoP unfolds in 3 phases. First, it lays the groundwork by establishing a conceptual framework and stakeholder engagement, drawing insights from best practices to shape a collaborative agenda and design pilot projects. The subsequent phase transitions into developing a transformative Community of Practice (CoP), emphasising resource optimisation, collective learning, and implementing co-creation methodologies to bolster innovation. The final phase focuses on sustainability and resilience, highlighting the role of FoodCoP ambassadors and leveraging dissemination and communication activities to share successes and insights. FoodCoP comprises a diverse network of stakeholders, including Startup Villages, regional networks, clusters, SMEs, research centres, and knowledge and innovation communities. Standing uniquely positioned to drive this initiative. With its comprehensive approach, FoodCoP aims to revolutionise the food industry's innovation landscape and ensure its impacts resonate well beyond the project's lifetime. The collaboration brings together a wealth of expertise and resources, promising to create a sustainable and inclusive ecosystem that supports the transformation of food systems through
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Targeting Cancer Stem Cells (CSC) for the development of more effective treatments to cure cancer patients' (CSC).

assistant: **Innovation**

Global cancer market is growing at a CAGR of 6.9% with an estimated value of $81bn in 2016. Although the huge R&D investment observed in the past years in the development of new treatments, there is still lack on an effective treatment in many tumour types. In particular, the median survival for glioblastoma multiforme (GBM), a high-grade brain tumour affecting 23,000 patients a year in US and EU, is 14 months and its 5-yr survival less than 5%. It is therefore urgent to develop more effective treatments against this fatal disease.It has been recently demonstrated that Cancer Stem Cells (CSCs) are responsible from tumour initiation, maintenance, relapse and treatment resistance, and therefore therapies targeting CSC should eradicate the tumour. Our team has discovered a molecular pathway critical in the regulation of CSC. The project presented here entails the proof of concept and pre-clinical development of a humanized antibody blocking this pathway. Our murine version of the antibody blocks CSC development in vitro by 54% and tumour recurrence in a mice model by 50%. At the end of the ERC POC project we will have a patent protected and fully humanized antibody active in vivo and in vitro and ready to enter Phase 1 clinical trials in humans to continue its commercialization process. The forecasted annual peak revenue for this therapeutic antibody is $530M with additional sales coming from line extensions in other cancer indications.With the ERC POC project we are dramatically increasing the commercial value of the therapeutic antibody, transforming an R&D finding (CSC are critical for cancer development) into a potential new solution to patients (a therapeutic antibody targeting CSC). Hence, we are de-risking the product, advancing it through the commercialization path
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project '“Microelectromechanical System wake-up receiver for Zero-Power sensor nodes”' (MEMS0P) under Horizon 2020.

assistant: **Objectives**

This project aims to design and fabricate a new fully passive microelectromechanical (MEM) wake-up receiver to be used in next-generation wireless sensing nodes. The metric for success will be to achieve the figures that are given by preliminary simulations (see later in the text). Specifically, this would be near-zero stand-by power (Psb<1 pW,DC) and ultra-low threshold power (Pth<-50 dBm,RF). Both of these values are orders of magnitude lower than what demonstrated through current state of the art WURs based on solid-state components.


**Keywords:** Wake-Up Radios, Micro-electromechanical Devices, MEMS, Piezoelectric resonators, AlScN, electrostatic resonators
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Catalases for low water textile processes' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Three alkali-thermophilic bacteria (two new species) producing catalases.Hydrogen peroxide monitoring methods suitable for textile bleaching application.Immobilised catalase enzymes stable at high pH and temperature.Molecular and catalytic properties of catalases from two new bacterial strains.A vertical and a horizontal reactor system for the continuous treatment of textile bleaching effluents.New carrier materials for catalase immobilisation.A combined process allowing reuse of enzyme treated bleaching effluents in dyeing.Industrial evaluation: Process is economically attractive for effluent treatment for reuse in dyeing especially in continuous bleaching/washing.The traditional textile wetting industry consumes about 100 litres of water to process about 1 kg of textile materials. Therefore there is a strong need for closed-loop technologies leading to a reduction in water consumption, especially since water resources in Southern European countries are limited. The objectives of this project are the development of enzymatic processes for on-site water treatment after textile bleaching and recycling of the same bath for further dyeing. Catalase enzymes will be used for hydrogen peroxide (H202) degradation in bleaching liquors as an environmentally benign alternative to chemicals, which lead to unfavourable high salt concentration in the process water. Currently there are no processes available using immobilised catalases, which would withstand the high-temperature and high-pH conditions used during textile processing and which would enable recycling of the enzymes. In the proposed basic research project the academic (UniP) and industrial (IndA+P) partners will work closely together to study the background for a continuous process meeting all those criteria. IndA experi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'IP-based Networks, Services and Terminals for Convergence Systems' in the context of a Sixth Framework call.

assistant: **Objectives**

INSTINCT will lay the foundation for the commercial take-up of the co-operation of broadcasting and telecommunication services for people on the move. It will develop a comprehensive vision of the business drivers, based on a study of user requirements and an active monitoring of the regulatory factors. It will also finalise all technical aspects necessary for a wide adoption of the system: multi-modal low-power terminals, scalable network and RF spectrum engineering solutions, standardised service provisioning and content creation tools and end-to-end quality of service. INSTINCT will build e-Europe by providing more radio network access and more affordable and attractive secure services to the end user. It will allow a non-discriminatory access for all potential users, i.e. for all citizens, and it will react to the users' demand for appropriate levels of quality in multimedia applications. It thus directly addresses the aims of eEurope 2005 by providing significant action to stimulate secure services on a widely available broadband infrastructure. Furthermore, it fosters e-inclusion by significantly enhancing the multi-platform provision of services with its cross-over" service concept. In the new business and regulatory environment, the longer-term activities of various international workgroups such as DVB and 3GPP have slowed down as industry searches for a shorter term for return on investment. INSTINCT will bridge this recent trend with the latest technological developments, allowing DVB to keep its worldwide domination as a broadcasting standard toolbox by making DVB-T mobile and by supporting the design and testing of the DVB-H standard. INSTINCT will thus make a major contribution in helping Europe maintain its leadership in mobile and broadband communication
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Identification of genes controlling economic traits in pig' (1994-1998).

assistant: **Innovation**

GENETPIG project will allow teams, from five countries of the European community, to accelerate the mapping and to identify GENes controlling Economic Traits in PIG.  Today, the number of known genes is relatively low in pig (160 genes are localised on this genome), and given this poor map resolution, it is difficult to identify closely linked markers allowing selection for traits, to suggest candidate genes, and to isolate the causal gene.  The existence of conserved chromosomal segments between mammalian species provided a basis for a more rapid progress in the search for candidate genes.. It is essential to use, in the optimum manner, these possibility of comparison between genome taken advantage, for example, of the well-documented human genome. These known method is called comparative mapping strategy.  We must extend knowledge, sharing strategies and data in a timely manner, build a dense network of comparison. 1) to locate as many coding sequences as possible in the pig genome; 2) to focus studies concerning genes with potential zootechnical interest where QTL (Quantitative Trait loci) are being found. Partners will use EST (Expressed Sequences Tags) isolated from tissue specific cDNA libraries (small intestine, ovary, liver and muscle) and human ESTs used in PCR heterologous conditions.  GENETPIG partners propose to increase fourfold the number of localised genes in the pig map. The six Partners (five countries: Denmark, France, Germany, Italy, Sweden ) will localize, in close collaboration, about 700 porcine EST or human EST on the pig genome using, essentially, available hybrid panels tool.  The result will be gathered in data base, using current computing and network possibilities, and will be recorded to the published homology relationships between species