RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enhancing Biogeochemical Essential Ocean Variables for European and Global Assessments', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Changes and variability in ocean biogeochemistry are poorly observed despite its profound impacts on ocean ecosystems and associated services, and sensitivity to and for climate. The overall aim of BioGeoSea is to significantly close the research and knowledge gaps on biogeochemical Essential Ocean Variables (BGC EOVs), validate them in-situ and in models, and use them to feed ocean metrics in the form of indicators and data products that reflect their relevance to the society. This aim includes updating EOVs requirements and specifications to enhance their usefulness in providing ocean biogeochemistry indicators, which BioGeoSea will develop and deliver. These indicators will reflect different spatial and temporal scales, and be focused around: 1) ocean acidification; 2) ocean deoxygenation 3) the biological carbon pump; and 4) greenhouse gas fluxes. BioGeoSea will: 1) improve the requirement setting of BGC EOVs; 2) Improve the observational capability of BGC EOVs over a large range of temporal and spatial scales; 3) Provide better representation of biogeochemical processes in models and more accurate predictions; 4) Improve ocean BGC data products that are invaluable to understand complex ocean phenomena; 5) Deliver ocean BGC indicators and engage actively with stakeholders. Key results will be communicated to international networks and entities for endorsement, approval and efficient dissemination of the outcomes. This project will help to better observe and deliver biogeochemical ocean data and information, and ultimately advance our understanding about ocean health and its role in climate regulation. BioGeoSea will demonstrate the importance of long-term observations of the ocean, focusing on BGC EOVs. The quality of information from all BGC EOVs will be improved,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Regularity and singularities in elliptic PDE's: beyond monotonicity formulas' (EllipticPDE).

assistant: **Concept**

One of the oldest and most important questions in PDE theory is that of regularity. A classical example is Hilbert's XIXth problem (1900), solved by De Giorgi and Nash in 1956. During the second half of the XXth century, the regularity theory for elliptic and parabolic PDE's experienced a huge development, and many fundamental questions were answered by Caffarelli, Nirenberg, Krylov, Evans, Nadirashvili, Friedman, and many others. Still, there are problems of crucial importance that remain open.The aim of this project is to go significantly beyond the state of the art in some of the most important open questions in this context. In particular, three key objectives of the project are the following. First, to introduce new techniques to obtain fine description of singularities in nonlinear elliptic PDE's. Aside from its intrinsic interest, a good regularity theory for singular points is likely to provide insightful applications in other contexts. A second aim of the project is to establish generic regularity results for free boundaries and other PDE problems. The development of methods which would allow one to prove generic regularity results may be viewed as one of the greatest challenges not only for free boundary problems, but for PDE problems in general. Finally, the third main objective is to achieve a complete regularity theory for nonlinear elliptic PDE's that does not rely on monotonicity formulas. These three objectives, while seemingly different, are in fact deeply interrelated.


**Keywords:** elliptic PDE,  free boundaries
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Enhanced information retrieval and filtering for analytical systems' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Today successful competing on the market requires better handling of external and internal information in companies and local governments. Their managers demand tools that could gather, process and store information and knowledge - management information s ystems (MIS). Our key competence is information filtering for MIS. The information filtering system is an access service that stands between information source and information consumer, providing a personalised view on the information space. Contemporary i nformation retrieval and filtering (IRaF) systems lack the appropriate representation of user information needs and information itself. This has motivated us to undertake a project that would enhance our IRaF key competencies, and also improve IRaF system in order to better satisfy user needs. Our innovative concept is to join the achievements in information filtering, knowledge representation and decision support systems. Semantic Web technologies and especially the use of ontologies, are expected to enabl e a much higher degree of automation in performing operations pertaining to the searching and extracting information. In order to enhance the capabilities of IRaF we need training in the following areas: formal models of ontologies, software and tools for ontologies, Semantic Web and Web Services, human language technology, decision making. Our project is scheduled for 4 years and requires 48 person-months (24 p-m for incoming). Scientific quality of the training is assured by a co-operation with leadingres earch centres from Austria, Germany, The Netherlands, Norway, and UK. The main goal of the knowledge transfer is to build new competencies of our Department in order to achieve a European level of research in information retrieval and filtering from the In ter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Biophysical principles of cellular morphogenesis' under Seventh Framework.

assistant: **Concept**

Living cells are endowed with structure and mechanical stability by an intricate elastic network of protein filaments known as the cytoskeleton. These filaments are stiff on the scale of the cell and thus readily deform the cell membrane, while simultaneously being affected configurationally by spatial confinement. The coupled morphogenesis of cytoskeleton and membrane ultimately appears as dynamic rearrangements that drive physiological processes such as cell migration or division. I strive to unravel biophysical principles of cell morphogenesis. To this end, I propose to construct biomimetic cell models by confining actin biopolymer gels to cell-sized lipid vesicles mimicking cellular confinement. I will systematically investigate the interplay between entropy-driven organization, and that induced by cross-linker proteins which connect actin filaments, or motor proteins which actively slide them. A key innovation lies in the bottom-up approach of gradually increasing system complexity to eventually achieve a model which is far more realistic than existing assays. The system permits quantitative measurements of network and membrane shape (using fluorescence microscopy) and of local and global mechanical properties as well as active driving (using innovative particle tracking microrheology). This will allow me testing and development of new theoretical models. The proposed project promises to significantly advance our understanding of how cells orchestrate their shape and movements, and to foster novel medical treatments of diseases related to malfunctions of the cytoskeleton. Simultaneously, it addresses exciting physical questions raised by the unusual properties of cells, such as self-organization of non-equilibrium soft matter and material properties of polymer-memb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Enhancing car safety through accurate and real time side-slip angle assessment' to be submitted under Horizon 2020.

assistant: **Abstract**

When we drive, our safety is protected by a set of technologies that silently watch over the car’s behaviour, intervening tominimise the risk of accidents. The Electronic Stability Control (ESC) is by far the most impactful safety technology in cars,having reduced by around 40% the number of fatal accidents caused by the vehicle’s loss of control. Although effective, anyESC on the market suffer from one significant flaw: it cannot directly measure the sideslip angle, which is the key indicator ofskidding, namely the situation when the car deviates from the driver’s intended direction. The result is that present ESC candetect up to 80% of skidding events, thus still leaving room for improvements that can save lives. To address this issue andcatch a huge market opportunity, Modelway has developed a machine learning technology able to accurately estimate thevehicle’s sideslip angle in real time. And without adding any new sensor to the car. The key to obtain this result is theproprietary and patented Direct Virtual Sensor technology, which can be embedded in standard ESC units to further improvethe vehicle’s capacity to detect a skidding event. The DVS technology has been prototyped and extensive tests have beencarried out with car manufacturers and their Tier-1 suppliers, showing that the performances are already in line with theexpectations of a highly regulated industry as automotive. Now the development roadmap focuses on understanding thefeasibility of the integration of the DVS technology in commercial ESC units (Phase 1), to enable a co-development effortwith global ESC manufacturers (e.g. Bosch, Magneti Marelli) leading to a pre-commercial validation test-bed (Phase 2). Interms of business potential, with around 100 million cars sold each year globally and around 5
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Promoting co-designed sustainable health interventions with young changemakers for reduced risk of non-communicable diseases (NCDs) in urban Burkina Faso, Kenya and Tanzania' (NCDs), addressing dissemination and exploitation.

assistant: **Impact**

Changemaker objective: To implement & evaluate a sustainable health intervention program on health, nutrition, & environmental outcomes for the primary prevention of adolescent obesity & related non-communicable diseases (NCDs) together with adolescents in three rapidly urbanizing cities in Burkina Faso, Kenya, Tanzania. Background: There is an increasing epidemic of adolescent obesity that can contribute to adult obesity, morbidity & NCDs in a broader sense. Sustainable health interventions in urban low- and middle-income countries are critical in addressing lifestyle factors that contribute to obesity, diabetes & hypertension in later life, such as unhealthy dietary habits, inactivity & sedentary behaviors while shaping urban environments. Considering obesity is a complex issue that is influenced by wide range of interconnected factors, such as policy, environment, social, economic, cultural, behavioral, commercial, & biological determinants, a whole-systems approach that converges multiple sectors (i.e., health, education, environment, and agriculture) and stakeholders (i.e., adolescents, caregivers, staff, local government, communities, policymakers & implementers) are needed for obesity prevention in LMICs. Our strategy: Four evidence-based strategies, which will be adapted to context through a co-design process: 1) urban farming in schools with satellite farms and organic waste composting, 2) sustainable health modules for classrooms, 3) linking to healthcare workers through health talks using motivational interviewing techniques and 4) WHO Best Buys: Mass media campaign. Our evaluation: 3 cluster-RCTs in secondary schools, within the framework of urban Health & Demographic Surveillance Systems, implementation, process evaluation & cost-effective evaluation. Our e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Supramolecular attack particles to prevent cancer recurrence', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Supramolecular attack particles (SMAPs) are proteinaceous particles ~120 nm in diameter released from cytotoxic T cell and natural killer cells.  The particles have a core of cytotoxic proteins including perforin andgranzymes enveloped in a dense shell of glycoproteins including thrombospondin-1, which provides specificity for SMAP mediated killing. SMAPs released from T-cells are stable for at least 24 hours and can kill target cells autonomously.  The human cell line NK92 secretes SMAPs based on inclusion of perforin and granzyme B.   We have filed a patent on SMAP engineering and isolation and propose to work with experts in glioblastoma (GBM) and ovarian high-grade serous carcinoma (OC), and with interest from a biotech company with expertise in particle based therapies, to develop SMAPs as cancer therapies. GBM and OC are both diseases with high unmet need that are treated by surgical resection followed by chemo-radiation and patients succumb to local recurrence. GBM and OC don’t respond to immunotherapies.  As SMAPs are autonomously cytotoxic and can readily be delivered to surgical sites to destroy residual disease after resection we see an opportunity to develop SMAPs as therapies to reduce recurrence. The next  step after SYNECT completion will be to determine if SMAPs can be used to attack the tumour selectively without damage to normal tissues. We request funding to enrich SMAPs from NK92 cells supernatants and test these against GBM and OC cell lines in vitro.  We will also label SMAPs with fluorescent dyes and test biodistribution and toxicity in mouse models of intravenous, intracranial and intra-peritoneal injection.  This 1 year effort will enable mathematical modelling to design efficient preclinical studies in humanized mouse models in one or both of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Interhemispheric differences in cirrus properties from anthropogenic emissions' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Problems to be solvedRecent assessments on environmental impacts from changes in atmospheric composition stress the importance of natural and anthropogenic changes in aerosols, which may influence ozone depletion and climate forcing. One topic of growing concern is the expected increase in use of aviation fuel, which may have substantial effects on coverage, thickness, and frequency of occurrence of cirrus clouds. High water vapour contents in combination with low temperatures make cirrus clouds potentially very important in converting reservoir species to active chlorine in the midlatitude tropopause region. These high ice clouds also play an important role to the Earth's climate system. In fact, the IPCC-Aviation report of 1999 states that the key uncertainty, which has to be overcome in the future for better assessing the climate impact from aviation, is the knowledge of contrail and aerosol impact on cirrus cloudiness.Scientific objectives and approachAnthropogenic emissions predominantly occur in the Northern Hemisphere, which may result in a geographical difference in the effect by aerosols.Therefore, the objectives of the INCA project are to:I) Determine the difference in cirrus properties, which are of importance for climate and ozone distribution in the upper troposphere and lower stratosphere, in air masses with low and high aerosol loading.II) Provide a first set of data of the michrophysical and morphological properties of young cirrus clouds at southern and northern mid-latitudes, in relatively clean and polluted air masses, under otherwise comparable conditions. To meet the objectives, the INCA project conducts the first measurements ever performed of cirrus and aerosol properties in the Southern Hemisphere and compares these observations with comparable m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'APPLICATIONS OF ANALYSIS IN COMPLEX HYPERBOLIC GEOMETRY', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

This project is concerned with the study of geometrical and analytical aspects of the space of discrete representations of a surface group into the group of isometries of complex hyperbolic space, that is the complex hyperbolic quasi-Fuchsian space QC. It is the important dvelopment of the project the researcher I. Platis is carrying out as a Marie Curie fellow at the University of Durham under the supervision of J.R. Parker. Both projects are parts of a wider programme which aims to understand fully the ge ometry of QC. The main scientific objective of this project is to make further significant contributions to the wider research plan. There is a variety of deep geometrical results concerning the spaces of real hyperbolic isometries such us Teichmueller sp ace, many of them proved with tha aim of strong analytical tools such as quasiconformal mapping theory. An analogous theory already exists and it is fair to ask how it can be implemented in the complex hyperbolic setting. this question is considered one of the main problems in Complex Hyperbolic Geometry. Platis has already proved important and useful preliminary results in this area. By continuing his work on the subject in the Department of Mathematics of the University of Thessaloniki and by collaborati ng with N. Mandouvalos who is considered the top expert of Analysis and Hyperbolic Geometry in Greece, Platis will be able to give answers to the problem and simultaneously, his scientific and professional career will be immensely benefited so that after t he termination of this project he will be established as an independent researcher of Complex Hyperbolic Geometry in Greece.The Department is initially offering him a two-year contract with the view to being able to make this permanent subsequently. The fu nding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'HRMEG: High-resolution magnetoencephalography: Towards non-invasive corticography', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

To date, neuroimaging has provided a wealth of information on how the human brain works in health and disease. With functional magnetic resonance imaging (fMRI), we can obtain spatially precise information about long-lasting brain activations whereas electro- and magnetoencephalography (EEG/MEG) can track transient cortical responses at millisecond resolution. However, none of these methods excel in time-resolved detection of sustained cortical activations, which are typically reflected as bursts of gamma-range (30–150 Hz) oscillations, frequently present in invasive recordings in patients. Although we have recently demonstrated that in exceptional situations MEG can detect even single gamma responses, their signal-to-noise ratio is usually prohibitively low, largely due to the substantial distance (4–5 cm) between cortex and sensors. Here, I propose to exploit recent advances in a novel magnetic sensor technology—atomic magnetometry—to construct a new kind of MEG system that allows capturing cerebral magnetic fields within millimetres from the scalp. Our simulations show that this proximity leads up to a 5-fold increase in the signal amplitude and an order-of-magnitude improvement of spatial resolution compared to conventional MEG. Therefore, a high-resolution MEG (HRMEG) system based on atomic magnetometers should enable non-invasive recordings of cortical activity at unprecedented sensitivity and detail level, which I propose to capitalize on by characterizing cortical responses, particularly gamma oscillations, during complex cognitive tasks. Additionally, since atomic magnetometers can recover within milliseconds from fields of several tesla, I also propose to combine transcranial magnetic stimulation (TMS) with MEG, leveraging the reciprocity of TMS and MEG and th