RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Molecular dissection of inflammatory pathways'.

assistant: **Concept**

Inflammatory diseases are highly prevalent, often chronic diseases that cause diminished quality of life and are connected with major causes of death in Western societies. Despite their societal impact, their pathomechanism is incompletely understood, hindering development of novel therapeutic strategies. In particular, little is known about the intracellular signal transduction processes involved in the tissue destruction phase of aggressive autoimmune diseases such as rheumatoid arthritis. The present proposal aims to clarify this issue using in vivo and in vitro studies on genetically manipulated mice. During the proposed studies, mice deficient in various signal transduction molecules such as Syk, PLCg2, Gab2 and p190 RhoGAPs will be used to test their contribution to inflammatory responses. In vitro studies will test the activation of major effector cells of inflammation (neutrophils, macrophages and osteoclasts) while in vivo studies will utilize mouse models such as autoantibody- and cytokine-induced inflammatory arthritis or autoantibody-induced glomerulonephritis. Further studies will be performed to test the contribution of the above signaling molecules to disease pathogenesis in a lineage-restricted manner, using the Cre-lox approach. Finally, wild type and mutant versions of the signaling molecules tested will be retrovirally re-expressed into the relevant knockout hematopoietic stem cells in vivo to allow structure-function studies during in vivo inflammation. Two novel transgenic strains and a knock-in (floxed) mutant will also be generated during the course of the project. Using state-of-the-art approaches and techniques, this project will provide information at unprecedented molecular detail on signal transduction mechanisms involved in inflammatory dise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cooperative Robots for Extreme Environments' (CoRob-X), addressing dissemination and exploitation.

assistant: **Impact**

CoRob-X develops and demonstrates enabling technologies for multi-agent robotic teams. The primary target application is the exploration of planetary surfaces, with a focus on hard-to-reach areas. CoRob-X builds on robotic hardware provided by the project consortium and software building blocks developed within the framework of the SRC Space Robotics Technologies. These building blocks are reused and extended to support a multi-agent exploration team of robots. A first iteration of the Conceptual Study led us to select a set of specific scenarios for the exploration of Lunar surface and lava tubes with a team of three Robotic Explorer Units (REUs). The  rovers are at different scale (dimensions, mass) and exhibit different locomotion principles/capabilities. The final demonstration will be performed in a Moon/Mars (outdoor) analogue simulation environment and include the use of an instrument that will be used on a real space mission (same ground penetrating radar GPR as used in Exomars), and will be aimed to demonstrate how to improve the performances of a space mission (in terms of scientific return, timeliness, availability, responsiveness, and operation costs) and maturity level of the existing building blocks.Additionally, a terrestrial mining scenario will be demonstrated that reuses the SW packages developed for the space mission but on  different robotic platforms. The final demonstration for the terrestrial scenario will be in the mining facilities of Santa Barbara Foundation.CoRob-X is firmly embedded in the SRC Space Robotics Research ecosystem. Corob-X´s team is formed by key partners that have been involved in each and every previous OG,s from the 1st and 2nd PERASPERA SRC call (from OG1 to OG11). Therefore, we can maximize the capability for re-use and iden
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Emergence of Global Non-Governmental Spaces in Education: Non-Governmental Organizations and the Global Turn in Education' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

About 30 per cent of the world’s population are children. Children are not only the most important people for their parents, but also the future of our societies. Providing them with the best possible education is of inestimable importance. Which education is best, however, is a question that is continually being negotiated. For a long time, this question was answered primarily by national governments. For some years, however, ongoing processes of globalisation are significantly shaping education, leading to what scholars term the global turn in education. Non-governmental organisations (NGOs) have become core actors in this global turnaround. They are increasingly joining forces in education-related transnational networks (i.e., global non-governmental spaces) that express an obvious claim to influence schools and education systems worldwide. Hence, questions arise about the associated risks and benefits for schools, particularly with regard to education's role in promoting educational achievement and equal opportunity among students from different backgrounds. However, despite this increasing relevance scholars have neglected to investigate transnational networks of NGOs in the field of education. EmergEd aims to drastically improve scientific knowledge on NGOs in education by analysing the emergence of global non-governmental spaces in education and how they influence education systems and schools – a contribution from which a far-reaching scientific – and in the long run societal – impact is to be expected. It will do so by developing an inter-disciplinary methodology integrating (inferential) Social Network Analysis (SNA) and Discourse Network Analysis (DNA), alongside qualitative data analysis based on Grounded Theory, to contribute to further theory building. Thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Control exchange-coupling Interactions in poRphyrin-based Quantum logIc gaTes'.

assistant: **Objectives**

The role of quantum computing in simulating quantum and complex systems (e.g., molecular and biological systems) is central to the ""second quantum revolution"", generating enormous investments of industrial companies (e.g., IBM, Google, etc.) and EU members. Current technologies are mainly based on solid-state fundamental units, i.e., the qubits, whose working principles rely on superconductivity or electron/nuclear spin physics. Beyond them, molecular systems based on magnetic compounds are attracting specific interest in the community. By exploiting the versatility of molecular systems and the infinite possibilities enabled by synthetic chemistry, it is possible to engineer the systems' physical and chemical properties. For instance, several qubits can be interconnected within a single structure through organic and coordination chemistry approaches, thus improving more complex structures for implementing advanced quantum logical operations (i.e., quantum logic gates). The CIRQUiT project aims to go beyond the current state-of-the-art molecular quantum logical units by introducing molecular machines for quantum information processing. The three main ingredients of this project are: i) organic and coordination chemistry, ii) light, and iii) magnetism. Two molecular qubits will be anchored to a central diamagnetic photochromic unit acting as a switch of magnetic interactions. The differences in magnetic anisotropy properties of the two qubits will keep them distinguishable and manipulable through microwave pulses. By exploiting cyclization and cycloversion reactions of the photochromic core (enabled by continuous or pulsed irradiation with UV and Vis light sources, respectively), it will be possible to switch exchange coupling interactions between side units. In this wa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pushing the limits of online mass spectrometry' (EXOTRAP).

assistant: **Concept**

Mass measurements of utmost accuracy are extremely relevant for many physics areas: For particles like the electron or the nucleons, the mass represents fundamental properties of building blocks of nature. For complex composite quantum mechanical systems such as molecules, atoms and nuclei, masses allow to determine the binding energy of the system and thus give access to all fundamental physical forces acting between its constituents. Furthermore, mass measurements allow tests of symmetry concepts in physics and searches of physics beyond the Standard Model. Accurate mass determinations are also essential for reliable nucleosynthesis calculations in astrophysics or for testing mass models applied for theoretical mass predictions of even more exotic isotopes. Penning traps have solved the problem of isobaric and also very often that of isomeric contamination and are presently the mass spectrometers enabling the highest accuracy and resolving power. For a stable particle or stable nuclide, its mass can be determined with a relative accuracy reaching 10-11 and by performing the complete experiment with only one single ion. In the case of radionuclides, masses could be measured with a relative mass uncertainty better than 10-8 (e.g. Mg-22), a resolving power approaching 10 million (Hg isotopes), production rates as low as 1 ion/s (No-252), half-lives as low as 10 ms (Li-11), and for singly or maximum doubly ionized ions. However, these impressive performances in accuracy, resolving power, sensitivity and applicability could not be achieved simultaneously for one specific species. Therefore, this project aims at pushing the present limits of online mass spectrometry even further, thus allowing studies of nuclides and physics questions inaccessible before. To reach this goal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Species specific dna markers for food authentication' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The research involves the identification of target DNA sequences for use in the determination and differentiation of species of plant or animal origin. The aim is to develop suitable DNA-based methodology that can be applied to processed food products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Ketone Body Mediated Modulation of GABAergic Signaling: Mechanisms and Consequences'.

assistant: **Innovation**

The brain’s high metabolic requirements mean that the mantra of nutritionists worldwide, “You are what you eat!” could be more accurately phrased, “you are what your brain metabolises!”. While glucose provides the major source of energy for the brain, ketone bodies (KBs) also play a critical role during the neonatal period, during fasting and during periods of metabolic stress (1,2,3). The ability of KBs to powerfully modulate neuronal activity is highlighted by the fact that the ketogenic diet has been used for the management of “difficult -to-control” seizures since the 1920s (4,5), and is currently undergoing trials for the management of a variety of neurodegenerative disorders (6). However, neither the molecular mechanisms by which ketone bodies act, nor the role of KBs during normal development and physiology are known. In vitro studies in a wide variety of animal species and brain structures, indicate that GABAergic signalling is depolarising during the early neonatal period (7). However, preliminary results, in vitro and in vivo, suggest that KBs induce a decrease in [Cl-]i and consequently a hyperpolarising shift in GABAergic signalling in neonates. In this project we will study both the mechanisms of this KB mediated effect and its consequences for neuronal network activity in vivo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Introducing the first fully flow-conveyed and magnetically-steered microcatheter system', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Minimally invasive medical procedures, such as endovascular catheterization, have drastically reduced procedure-associated risks for patients and costs for hospitals. However, practitioners still cannot quickly and safely reach deep body tissues due to the miniaturization issues associated with the existing manufacturing paradigm and the tedious process of navigating commercially available catheters. MagFlow introduces an innovative approach towards minimally invasive surgery that realizes the delivery of ultra-lightweight and ultra-flexible microscopic probes by taking full advantage of the existing viscous flow inside blood vessels. With this technique, the microengineered devices are transported through vascular networks with arbitrary complexity almost effortlessly. We developed an endovascular microrobotic toolkit with cross-sectional area that is approximately three orders of magnitude smaller than the smallest microcatheter currently available for chemical, mechanical, and electrical interrogation. Our technology will improve the state-of-the-art practices as it enhances the reachability, reduces the risk of iatrogenic damage, drastically increases the speed of robot-assisted interventions, and enables the deployment of multiple leads simultaneously through a standard needle injection. As a result, several invasive surgeries can shift to endovascular interventions, knowledge on neuronal electrophysiology can grow significantly, and a novel type of brain-machine interface can be established. The goal of the MagFlow project is to both explore the commercial viability of our unique technology and take the first steps towards the clinical trial phase by adapting the platform for in vivo experimentation.


**Keywords:** robotics, microtechnology, minimally invasive in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Eu-day for clean and safe vehicles during evs 18 (EU-DAY - EVS 18)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

A EU-Day is planned directly after the 18th International Electric Vehicle Symposium (EVS 18) that will be held in Berlin on Oct. 24th and 25th, 2001. The EU-Day will contain the contractor's meetings of about 45 EU-supported contracts in the area of Clean and Safe Vehicles" in 4 different key actions. The main goal is an informative discussion between the different contract partners themselves as well as with experts from all over the world, which will create an exciting atmosphere of interchange of ideas. A panel discussion will be organized."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Fabrication and magnetic characterization of artificially nano-structured materials for ultra-high density magnetic storage media'.

assistant: **Innovation**

Moore's law predicts that magnetic bits of memories will early approach nano-meter sizes. However, there are a number of challenges that may impede the use of nano-sized magnets; some of them are related with intrinsic effects such as superparamagnetism that arises when material size approaches the nano-meter scale. Others are related with extrinsic effects as proximity effects, chemical interdiffusion, or roughness, so that, they must be excluded before addressing a solution to superparamagnetism. This proje ct is dedicated to analyze these key issues for the development of nano-structured magnetic media for high-density memories. The subjects to be studied are:(a) growth of arrays of patterned magnetic media, (b) characterization of the arrays, and (c) development of conceptual ideas that allow to overcome the fundamental limits imposed by their scale. Quantitative characterization tools will be used (x-ray and neutron diffraction, STM, AFM¿) to combine a quantitative study of the interfaces, adequate fabrication methods, and proper choices of materials. Although the solution is not obvious, it will be there if a detailed research is carried out. The solution to the superparamagnetic limitation is more complex. Some few key ideas are needed and fundamental research must be done to ascertain which approach is the most promising. A possible solution that will be investigated at the University of California is to take advantage of the Exchange Bias in antiferromagnetic/ferromagnetic (AF/F) layers, that provides an additional anisotropy to stabilize the magnetization, and can induce the reduction in the superparamagnetic length scale. Thus, magnetic dots made of AF/F bilayers will be prepared to study the possible role of exchange biasing on superparamagnetic onsets. Duri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Transduction of light signals in the oxyphotobacterium calothrix sp. pcc 7601', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The project aims at elucidating molecular mechanisms involved in the acclimation of cyanobacteria to changing parameters in the environment. It is focused on the adaptation of the light harvesting antenna of Calothrix spp. to the incident light wavelengths, a process called complementary chromatic adaptation (CCA). A detailed characterization of the RcaA and RcaB proteins, two transcription factors implicated in CCA recently isolated in the host laboratory, will be achieved. A main goal will be to prove the proposed identity of RcaA with glutamyl-tRNA synthetase, an enzyme also required for the synthesis of proteins and of all the pyrrolic compounds (hemes, chlorophylls, phycobilins). A detailed analysis of the different domains of this multifunctional protein will be carried out. Biochemical and genetic approaches will also be used for identifying and characterizing new elements involved in the perception of the light signal and its transduction to the effector molecules.  Training content (objective, benefit and expected impact) The proposed project will enable the candidate to complement the scientific skills he previously acquired by studying the regulation of nitrogen assimilation in a simple cyanobacterium and the transduction of signals in eukaryotic cells during oncogenesis. Nowadays recognized as having many potential biotechnological applications, cyanobacteria will in the near future increasingly benefit humankind.  Links with industry / industrial relevance (22)