RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Interactions between water treatment membrane surfaces and biofilms'.

assistant: **Concept**

The present project will study the interaction between biofilm formation and structure, membrane surface properties and performance, and the characteristics of the treated water. Such a study requires interdisciplinary interaction between experts in the synthesis, physical chemistry and technology of membranes who understand membrane properties and performance, and environmental microbiologists with expertise in the formation mechanism, structure and properties of biofilms.While researchers of the host organization BGU-ZIWR - have considerable expertise in membranes, knowledge on the mechanisms of biofouling and the techniques, knowledge on the mechanisms of biofouling and the techniques used to study the biofouling phenomenon is not available in any of the departments of BGU. It is proposed to form a close collaboration with leading laboratories in Europe in biofilm studies in order to form a solid basis for understanding the membrane -biofilm interactions in membrane based water treatment processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Pro-tumorigenic effects of TGFb - elucidation of mechanisms and development of selective inhibitors' (SelectiveTGFb-inhib) targeting Horizon 2020.

assistant: **Abstract**

Transforming growth factor-b (TGFb) is a multifunctional cytokine which has important functions during embryonal development and in tissue homeostasis. In cancer, TGFb is often overexpressed and has both tumor suppressor effects (induction of growth arrest and apoptosis) and tumor promoting effects (stimulation of epithelial-mesenchymal transition (EMT) of tumor cells, stimulation of angiogenesis and cancer associated fibroblasts, and suppression of immune surveillance).Our aim is to elucidate the mechanisms for the pro-tumorigenic effects of TGFb and to develop selective inhibitors which can be used to suppress tumor invasiveness and metastasis in animal models, and later on for treatment of patients with advanced cancer. We think it is important to develop selective inhibitors, which do not affect the tumor suppressive effects of TGFb, since complete inhibition of TGFb may cause severe side effects and may even promote tumorigenesis.We plan to:1.perform a systematic analysis of posttranslational modifications and interactors of the TGFb receptor I (TbRI) and II (TbRII), and determine their functional importance for the induction of various pro-tumorigenic pathways;2.determine the mechanism whereby TGFb activates the tyrosine kinase Src, and its role in invasiveness and metastasis;3.attempt to selectively inhibit the activation of phosphatidylinositol 3´-kinase by TGFb, in order to inhibit tumor cell survival and migration;4.elucidate the functional role in the nucleus of the cleaved intracellular domain of TbRI, and attempt to inhibit its formation and thereby tumor metastasis;5.determine the cellular compartment where the pro-tumorigenic signaling pathways are activated;6.elucidate mechanisms for TGFb-induced EMT and develop candidate low molecular weight inhibitors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Airborne Platform for Earth observation: the contribution to THESEO' under Fourth Framework.

assistant: **Concept**

Scientific information: It is proposed to undertake a two-phase tropical/Antarctic airborne mission with the aim of measuring trace gases and particles in the stratosphere. The tropical phase focuses on turbulent transport of tropospheric air into the stratosphere via tropical cumulonimbi, on stratospheric dehydration, cloud-related stratospheric chemistry, and the origin of the stratospheric background aerosol layer. The Antarctic phase will investigate early formation of polar stratospheric clouds, chemical processing and the role of gravity waves in ozone depletion. The ferry flights, from northern mid-latitudes to the base of the Antarctic phase and to the base of the tropical phase, will allow us to obtain information on global-scale transport across the sub-tropical mixing barrier". The airborne platforms suggested are a stratospheric high-altitude research aircraft, M-55, reaching up to 21 km, equipped with in situ and remote sensing instrumentation, supported by a pathfinding Falcon research aircraft, flying at 14 km with remote sensing instrumentation. This connection of the tropical and Antarctic phases, together with the combination of the high-flying stratospheric research aircraft and a lower-flying upper tropospheric aircraft, addresses the fundamental mechanisms underlying - the influence of the processes occurring in the tropical regions on the chemistry of the global stratosphere. - the downward trend of ozone in the middle latitudes. - polar ozone depletion. Financial information: Support by the EU is sought mainly for the tropical phase, while there already exists almost complete national funding for the Antarctic phase. Note also that the transfer flights from Europe to the tropical base will be largely financed as part of the Antarctic phase. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Improving egg and larval quality in pikeperch by broodstock management, husbandry and nutrition and sex control' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Recent research has demonstrated the feasibility of cultivating intensively pikeperch Sander (Stizostedion) lucioperca, a valuable fish under increasing demand for both the consumption (large size fish, 2-4 kg each) and the restocking (0+ and 1-year old fish) markets. However, the supply of eggs and larvae is still largely dependent on the spawning of wild breeders or captive fish held in ponds during the maturation process. Production of pikeperch eggs and larvae is thus seasonally restricted and extremely variable in quality and quantity. The main objective of the project is to secure the supply of high quality eggs and larvae of pikeperch. To reach that goal, the following specific objectives have been identified :1. Securing continuous supply of eggs and larvae by developing out-season spawning technology by temperature and photoperiod control.2. Investigating the effects of different husbandry and dietary variables on reproductive physiology and nutritional status of breeders and related effects on spawning performances, gamete and larval quality.3. Comparing the quality of eggs and larvae from breeders stocked in various environments (tanks vs cages vs ponds) and definition of a referential for the quality of pikeperch eggs and larvae.4. Setting efficient procedure of broodstock and larval rearing to produce pikeperch sex-reversed males and, in a second step, all-female populations of juveniles.To compare efficiently the effects of the different variables on gamete and larval quality, standardized larval rearing conditions will be precisely defined at the onset of the project and applied to all experiments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Constraints on Io's and Europa's atmospheres and interiors from modeling of the satellites' aurora' (AuroraMHD).

assistant: **Concept**

Two of Jupiter’s large Galilean moons - Io and Europa - are among the most interesting planetary bodies: Io is the most volcanically active body in our solar system and its neighboring moon Europa harbors a subsurface water ocean and high water vapor plumes were observed at its surface. The moon’s surfaces and atmospheres interact with the surrounded moving magnetized plasma forming a complex plasma interaction.Observations of auroral emissions from the moons’ atmospheres and numerical modeling of the plasma interaction are used to derive plasma physical, geophysical and atmospheric properties, such as the composition and the distribution of the moons’ atmospheres and subsurface oceans. However both approaches, observations and numerical modeling, are mostly treated independently and hence often provide an ambiguous interpretation. The research goal of this project is to combine the two approaches and the different data sets- in-situ measurements from the Galileo spacecraft and the large set of aurora images from the Hubble Space Telescope- in order to advance the understanding of the atmospheres, interiors and magnetic surroundings of Io and Europa and to investigate the influence of induction from a subsurface ocean on the moons’ aurora. This action will be fulfilled by an advanced magnet-hydrodynamic model which self-consistently simulates the plasma interaction and aurora emissions.The results of the project will advance the understanding of the properties of the moons and their plasma interaction, lead to several publications in peer-reviewed scientific journals and will provide useful input to the planning of future spacecraft observations such as the Jupiter Icy moon Explorer or the Europa Clipper mission. During the fellowship at the KTH I will greatly expand my
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Real Processing in Phase Change Memory' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Separation of processing and memory is the root cause of the main performance and energy bottlenecks in modern computers. In the PI's ERC Stg, we proposed to combine data processing and storage in the same cells, to develop a novel unit called the 'memristive memory processing unit' (mMPU). This unit was based on resistive RAM (RRAM), which is still not commercial in large capacity. A different memory technology, phase change memory (PCM), is commercially available in large capacity (for example, Intel's Optane has 1.5 TB memory), and can serve as an appropriate technology to form an mMPU with short time-to-market.In this PoC, we aim to experimentally demonstrate a working mMPU based on commercially-available PCM.This mMPU will enable fast and energy efficient computers that are cheaper than existing computers. This will impact different applications such as artificial intelligence, databases, and genomics. The mMPU-based computers will allow faster and cheaper execution of the aforementioned applications.In this proposal, we target the required technical and business steps required to develop such an mMPU and to commercialize it.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Support for realising new Member and Associate States’ potentials in transport research'.

assistant: **Concept**

TransNEW is a Horizontal Activity for the implementation of the Transport Programme.  It is a Coordinating and Support Action aimed at supporting transport research activities in the New Member States. It contributes to the implementation of the Framework Programme and to the preparation of future Community research and technological development. It also stimulates, encourages and facilitates the participation of the New Member States and particularly SMEs in those countries in national, regional and European research. TransNEW has one primary focus to assess, analyse and define strategies for realising New Member and Associated States potentials in transport research. This is absolutely in line with the Integration/Efficiency Topic TPT.2008.8. TransNEW aims to map the transport research capacities in new Member States (and Associated States) by analysing their transport research activities to establish their recent patterns of collaboration. With this information evaluated by Mode and by Activity this will then be used to maximise the benefits of transport research at regional level and at a mode level.  TransNEW covers all the transport modes including Aeronautics and aims to evaluate research capability in order to support the involvement of New Member States in a number of topics and potentially exploit the synergies between Air transport and surface transport modes. Through mode evaluation, TransNEW will assess the research actors who can make an active contribution to the common (transport research) objectives of advancing competitiveness, anticipating and responding to the socio-economic and environmental challenges of the transport system.   TransNEW will cluster the research capacity results by Activities.  The five Activities are: 1. Greening - environmental i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dynamics of memory: The Notion of representation revisited' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

This project aims at contributing to our understanding of the dynamics of change in complex systems. To do so, we propose to revisit the notion of representation as an emergent process by reconsidering the relationship between cognitive invariants and variability, and by suggesting that it is not the invariants that are represented, but rather the dynamics that makes it possible for the system to reach invariance. In this framework, variability in performance is seen as a central determinant of adapted behaviour.The importance that variability plays in behaviour is highlighted by the fact that living organisms have a remarkable capacity to adapt to a multitude of constraints. This suggests that variability plays a central role in making adaptive stability possible, that is, a kind of stability that also remains flexible enough so as to continue to be able to adapt to changing constraints from the environment. We surmise that achieving this kind of adaptive stability crucially depends on the continued presence of variability in the cognitive system. The work we propose to undertake is to study the process of consolidation in memory, seen as an implicit process as it has been approached in the domain of implicit learning (Cleeremans, 1997, 2002). Because response variability is an unconscious phenomenon, a good way to explore the functional role of variability is to focus on elementary learning situations, that is, implicit learning situations.In this context, I will explore three central issues:(1) the extent to which response variability is an implicit or explicit process,(2) the importance of rules in movement planning, and(3) the computational modelling of motor performance and the study of dynamics of change, using recurrent networks.This work will be conducted at th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The BRight Side: Understanding the role of the Brain’s Right hemisphere for language development in autism' under Horizon Europe.

assistant: **Concept**

BRight will investigate alternative right-hemispheric pathways for language development in autism. While language is especially left-lateralized in the typically developing brain, there is increased right-hemispheric involvement in autism. It is unclear whether these right-hemispheric neural pathways contribute to language deficits or if they form a potential compensatory network, facilitating an alternative route for successful language development. This is especially interesting to examine in the preschool age as language abilities are at their most variable and intervention strategies at their most effective. BRight has four objectives: 1) characterize typically developing neural pathways for language in the left and right hemisphere; 2) compare individua neural pathways of autistic preschoolers to the typically developing children; 3) relate right hemisphere variables to a preschool battery of language assessments; 4) longitudinally examine preschool neural variation to school-age language abilities. BRight will achieve this by collaborating with an existing research consortium that studied autistic preschoolers using MRI and by adding a new time point to examine these children now that they are at the school age. BRight will overcome previous limitations like an overreliance on isolated brain measures and a dependence on group-level analyses that cannot capture the heterogeneity of the autism spectrum by employing novel data fusion and normative modeling approaches. By integrating across multiple brain measures (including structural MRI, diffusion MRI and resting-state fMRI). The highly interdisciplinary approach taken in BRight will fundamentally impact our understanding of brain-behavioral correlations and the neural foundation of language in autism. The project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Asymmetric endosomes in asymmetric cell division and tumorigenesis'.

assistant: **Concept**

Recent Drosophila reports show that directional Notch signalling during asymmetric cell division is mediated by asymmetric endocytic trafficking. Unpublished data from the host lab showed that directional Notch signalling is initiated by the directed targeting towards the signal-receiving cell of specific endocytic compartments, the Sara endosomes, which carry the receptor Notch and its ligand Delta. I will combine automated quantitative analysis of the movement of these endosomes with an RNAi screen to identify cytoskeletal elements controlling Sara/Notch/Delta endosome dynamics. In vitro reconstitution of endosomal trafficking and biophysical micro-manipulation of these endosomes will unravel the fine molecular role of the machineries discovered in the screen. I will then study asymmetric endosomal dynamics in the stem cells of the fly brain in wild-type and tumorigenic conditions. The ultimate goal is to uncover the relation between endosomal dynamics, stem cell self-renewal and brain tumorigenesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Maximizing the Therapeutic Potential of Music through Tailored Therapy with Physiological Feedback in Cardiovascular Disease' (2014-2020).

assistant: **Innovation**

Cardiovascular disease is the world’s leading cause of death, and hypertension is its foremost medical risk factor. Reducing blood pressure in hypertensive patients has positive cardiovascular effects, and music listening offers non-pharmacological ways to regulate heart rate and blood pressure. Presently, the most effective way to administer music inventions with long-lasting effects is labor-intensive and relies on professional therapists’ intuitions, making it non-scalable to large cohorts. HEART.FM is an app-creation initiative to democratize access to personalized music medicine interventions, informed by physiological feedback. Current music therapy apps fail to address the subjectivity and specificity inherent in individual music response; a gap further exists between music therapy apps and physiological feedback. By leveraging advances in wearable ECG monitors and portable blood pressure sensors, HEART.FM will offer music therapy based on individual users’ physiological feedback around musical change points and transitions, which correspond to emotionally salient moments in music listening. HEART.FM exploits the music structure knowledge and cross-modal music-physiology analysis methods developed and trialed in the ERC project COSMOS to advance the state of the art by linking physiological feedback with computational music structure analysis to provide personalized music listening therapy to achieve targeted autonomic nervous system responses. A development goal will be to make HEART.FM ready for large-scale deployment in randomized, controlled research trials that can establish music-hypertension cause-effect relationships for healthy individuals as well as hypertensive patients. HEART.FM will benefit the research community by offering a crowdsourced portal for