RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Evaluation et utilisation de la biodiversité des microsymbiotes de Calliandra Calothyrsus" pour optimiser la production fourragère au sein de peti tes exploitations agricoles en zone tropicale humide"' under Fourth Framework.

assistant: **Concept**

The main objective of the project is to optimize the forage production of C. calothyrsus on small farms by inoculation with highly efficient strains of rhizobia and/or mycorrhiza strains selected under laboratory, greenhouse and field conditions. In order to achieve this objective we will investigate the main symbiotic characteristics of C. calothyrsus, evaluate a range of potential inocula, and attempt to produce a suitable microbial inoculum for inoculating plants under field conditions.Expected OutcomeThe participating research organizations will be able to produce and dispense selected strains of microsymbionts suitable for use on farms in order to increase forage production. Researchers involved in the project from both European and third country institutes will have the opportunity to train in technical areas, such as inoculum production, and in scientific areas, such as survey of the biodiversity of rhizobia strains and study the persistence of rhizobia after inoculation in soil.Research activities are concentrated in two main areas :1. Collection of microsymbionts of C. calothyrsus. The project will establish a large collection of rhizobia and mycorrhiza isolated respectively from the nodules and roots of this species harvested in its native range (Honduras, Costa Rica and Mexico), and in humid countries where it has been successfully introduced (Cameroon, Kenya and New Caledonia). After evaluation of the biodiversity within the collection of microsymbionts, a symbiotic screening will be carried out in the laboratory and greenhouse in order to select the most efficient strains for inoculation under field conditions.2. Field inoculation of C. calothyrsus. Existing methodologies for producing rhizobial inoculum and inoculating plants under field conditions will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The neural correlates of the self in altered states of consciousness.'.

assistant: **Innovation**

The consciousness of self is fundamental to our human existence. In several mental health afflictions there appears to be a change in the relation between the self and conscious experience: in anxiety and depression, people can be absorbed in negative thoughts, while in (traumatic) dissociation, distance between the self and conscious experience can occur. Studies report that meditation and hypnosis can help alleviate symptoms of anxiety, depression and post-traumatic stress, but it is unclear why. I hypothesise that meditation and hypnosis change the relation between the self and the conscious experience. I aim to study the neural correlates of these changes in self-consciousness during meditative and hypnotic states with functional Magnetic Resonance Imaging in healthy controls and intracranial electroencephalography in people with epilepsy, which is the only way to directly measure the activity of deep brain structures thought to play a role in self-consciousness, such as the insula. I will combine these measurements with first-person interviews and behavioural tasks. This innovative study will elucidate the neural correlates of the consciousness of self and will help understand the reported beneficial effects of meditation and hypnosis on mental health.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Natrocarbonatites: are they unique, or are they keys to understanding how volcanoes erupt igneous carbonate from the Earth's mantle?'.

assistant: **Concept**

We aim to establish whether the Oldoinyo Lengai volcano, Tanzania is unique in erupting Na-rich 'natrocarbonatite', or is representative of other carbonatites. As the only active carbonatite volcano, Lengai has been the subject of many studies but whether it truly represents other carbonatites is key to understanding one part of the C cycle: that which brings carbonate from the Earth's mantle. With access to a unique collection of altered Lengai lavas, we will construct [1] a model of subsolidus alteration in Lengai and other carbonatites, linking the various carbonatite types, and [2] a detailed analysis of the alteration, including identifying key minerals to recognise weathered natrocarbonatite in volcanic successions, sediments and soils. We will undertake a pilot study of east African soils and sediments from archaeological sites to search for evidence of carbonatite. We will ascertain whether Lengai is unique, discuss the role of Na in carbonate magmas, and collaborate with soil scientists and archaeologists to apply the results to land management and reconstruction of palaeoconditions. Based at the Natural History Museum London, a world centre for carbonatite studies, and in collaboration with experts in Germany, Hungary and UK, we will undertake a meticulous and comprehensive approach involving advanced studies in mineralogy, petrology, geochemistry (including isotopes), soil science, and thermodynamic modelling. Additionally, the project will provide interdisciplinary training in petrology, soil science , modern analytical techniques and the public presentation of science to enable the candidate to become a research leader in Russia, with a return phase at St Petersburg University. The project contributes to 3 aims of structuring the ERA: human mobility, commun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Flying Electromagnetic Toroids' (FLEET) under Horizon 2020.

assistant: **Objectives**

In this project I will study the generation, detection, and interaction with matter of Flying Toroids, a new type of light pulses never experimentally studied before. This represents an exciting opportunity to advance optics and electromagnetism in a radically new direction since Hertz, Marconi, Popov and Tesla developed technology for generating, detecting, and communicating with transverse electromagnetic waves. Conventional transverse electromagnetic waves propagate in free-space with the electric and magnetic field vectors perpendicular to the wave propagation direction, forming the famous triad. Theoretical analysis of recent years has shown that another, very different type of waves exists, which propagate at the speed of light, but only occur as short bursts of electromagnetic energy in the form of Flying Toroids. Flying Toroids are inseparable solutions of Maxwell equations with a unique, doughnut-like configuration of the electric and magnetic fields.  Flying Toroids interact with matter in unique ways, drastically different from that of conventional electromagnetic pulses. In a broader context, the electrodynamics of Flying Toroids is an exciting emerging field of optical science linked to intriguing recent developments in physics such as toroidal dipoles and anapoles, and, due to their topology, to Majorana fermions and skyrmions. Building on my recent proof-of-principle demonstration of Flying Toroid generation through conversion of few-cycle conventional transverse light pulses in artificial photonic nanostructures, my goal for this project is to experimentally study and understand the fundamental properties of Flying Toroids and their interaction with matter at optical frequencies, and to assess their potential for developing new technologies.  In my visio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The National Centre for Research and Development (NCRD) as a Centre of Excellence for EU-Jordan S&T Cooperation: Towards Jordan's Integration into ERA' (NCRD) under Seventh Framework.

assistant: **Objectives**

The overarching aim of the J-ERAcenter is: To contribute to the effective integration of Jordan into ERA, through building the National Centre for Research and Development (NCRD) organisational, strategic and human capacities to actively participate in European S&T partnerships and execute large-scale projects in the key area of Renewable Energy, with a view to creating a centre of excellence within Jordan and actively promoting further dissemination and replication in the region. Specifically J-ERAcenter aims:•To build capacities in international R&D cooperation and EU project management, by providing targeted training to NCRD staff and researchers and enable them to replicate the knowledge benefiting a wider target group of researchers in Jordan.•To strengthen direct links between research teams of NCRD and their EU counterparts and initiate joint R&D initiatives in the area of Renewable Energy, through a series of networking/partnering events and facilitating mobility of researchers.•To ensure firm and sustainable implementation of the enhanced capacities at NCRD with a view to promoting the centre’s international competitiveness and improve its response to socio-economic challenges; through implementing specific internationalisation, visibility, IP and competitiveness strategies (for enhancement of the institutional development strategy), and the implementation of a R&D Cooperation Unit.•To promote the visibility and impact of this pilot action, positioning NCRD as a Centre of Excellence for EU-Jordan RTD cooperation, via targeted multiplication and dissemination actions (networking events, info-days, seminars).Jordan’s leading research centre in Renewable Energy is the main beneficiary and coordinator, due to its high multiplier potential to act as catalyst for int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Plasma-assisted development and functionalization of electrospun mats for tissue engineering purposes' under Seventh Framework.

assistant: **Concept**

In this project, I will explore the unique combination of two fascinating research themes: electrospinning and plasma technology. Electrospun nanofibrous matrices (so-called mats) are an exciting class of materials with a wide range of possible applications. Nevertheless, the development and functionalization of these electrospun materials remain very challenging tasks.Atmospheric pressure plasma technology will be utilized by my research group to create advanced biodegradable electrospun mats with unprecedented functionality and performance. To realise such a major breakthrough, plasma technology will be implemented in different steps of the manufacturing process: pre-electrospinning and post-electrospinning.My group will focus on four cornerstone research lines, which have been carefully chosen so that all critical issues one could encounter in creating advanced biodegradable electrospun mats are tackled. Research cornerstone A aims to develop biodegradable electrospun mats with appropriate bulk properties, while in research cornerstone B pre-electrospinning polymer solutions will be exposed to non-thermal atmospheric plasmas. This will be realized by probing unexplored concepts such as discharges created inside polymer solutions. In a third cornerstone C, an in-depth study of the interactions between an atmospheric pressure plasma and an electrospun mat will be carried out. Finally, the last cornerstone D will focus on plasma-assisted surface modification of biodegradable electrospun mats for tissue engineering purposes.Realization of these four cornerstones would result in a major breakthrough in their specific field which makes this proposal inherently a relatively high risk/very high gain proposal. I therefore strongly believe that this research program will open
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Role of the circadian clockwork in the anterior pituitary gland' (2002-2006).

assistant: **Concept**

The aim of this proposal is to investigate the physiological relevance of the molecular circadian clockwork expressed in peripheral organs. This question will be addressed in a new and original paradigm: the endocrine pituitary gland. Indeed, several so-called clock genes that form the molecular cogwheels of the biological clock have recently been identified. Surprisingly, besides being activated in structures known to host an internal clock (namely the suprachiasmatic nuclei, SCN, in mammals) they are also expressed in many -if not all- other tissues, among which the pituitary gland where strong oscillations of the clock machinery have been found. Using mutant mice that bear an altered clock, we will research the impact of the clock upon several key parameters of the gland physiology such as electrical activity of endocrine cells and hormonal secretion in basal and stimulated conditions.This project constitutes the frame of a stable research position of the applicant in his native country. It will be achieved thanks to several scientific collaborations at the national, European and worldwide levels. Results obtained from this research are expected to answer critical questions in fundamental chronobiology and cell biology but also, the understanding of the fine mechanisms that pace the daily functioning of organs may have potential important outcomes in modern medicine, e.g. development of chronotherapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Regulation of cytotoxic T lymphocyte activity at the lytic synapse' (2002-2006) under Sixth Framework.

assistant: **Objectives**

The lytic activity of cytotoxic T lymphocytes (CTL) plays a central role in the control of viral infection, cancer and homeostasis. The lethal hit of CTL is delivered to the target cell at the level of a highly organized synaptic structure (lytic synapse). How composition and organization of the lytic synapse contribute to the regulation of the lytic activity is largely unknown. The focus of this proposal is to study the lytic synapse of CTL isolated from patients affected by life-threatening primary immuno deficiencies (PID). CTL from patients with genetic mutations causing defects in cytolytic activity are unique natural knock-out models. The following PID will be considered: 1) Wiskott-Aldrich Syndrome due to WASP deficiency, 2) X-linked Lympho-Proliferati ve disease due to SAP deficiency, 3) Familial Hemophagocytic Lymphohistiocytosis due to perforin deficiency. This project will investigate the dynamics of molecular events that occur at the lytic synapse formed between CTL and antigen-loaded antigen-presen ting cells, using time-lapse video recording of the distribution of receptors and signalling components. Analysis of CTL activation and lytic activity will be performed in parallel. These approaches will be combined to lentiviral vector-mediated transfer o f untagged or GFP-tagged constructs encoding WASP, SAP and perforin, in order to visualize these proteins and to correct the lytic function of CTL from PID patients. In addition, a proteomics approach will be employed to identify novel proteins in healthy CTL that could complete our understanding of the lytic synapse architecture and function. This project will provide new insights in the mechanisms regulating CTL activity and in the physiopathology of severe PID. In addition, it will be instrumental for th e d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Precision Lethality to overcome clonal heterogeneity in high-risk neuroblastoma' (2021-2027).

assistant: **Concept**

Tumors are heterogeneous in nature due to genetic instabilitTumors are heterogeneous in nature due to genetic instability, ongoing selection, and variable microenvironments with local adaptation. Many tumors thus necessitate combinatorial drug treatments to reach all cells. This is true also for neuroblastoma, the most common extracranial solid pediatric tumor. Despite the well-known importance of clonal heterogeneity, most in vitro drug combination strategies, including commonly used synergistic interaction, do not quantify subclonal drug response. Here recently developed cell barcoding strategies will be used to monitor survival of thousands of individual subclones in neuroblastoma organoids, under different drug perturbations. This lineage tracing strategy allows identification of cell populations that survive a specific drug, and to find other drugs that specifically target those cell populations. I call this strategy “Precision Lethality”.In this research program two different precision lethality methodologies will be developed, one where cell barcoding is used to identify drug combinations with low cross-resistance, and one that uses the possibility to express the barcode so it can be captured by single cell RNA sequencing. This allows assessing the transcriptional state before drug perturbation of cells that are known to be either drug resistant or drug sensitive. Combined with publicly available drug sensitivity data repositories, this will be used to construct a deep learning model to predict drug sensitivities of individual cells.Successful completion of this multi-disciplinary research program will identify and verify new drugs to complement standard of care consolidation therapy for neuroblastoma. I also envision that these studies will showcase to the broad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cost-effective automated process for producing innovative high-performance electric motors' (SPARK) targeting Horizon 2020.

assistant: **Abstract**

DEMA is a high-tech SME, world leader of machines for the production of electric motors. We have developed a new manufacturing process and associated machinery enabling production of the emerging segmented motors, where stators and rotors are composed by modules (segments). Compared to traditional motors the segmented ones are: • cheaper, because use of raw materials is more efficient and assembly is simplified,• greener, because waste material during production is massively reduced,• high-performance, thanks to optimization of electrical phenomena.The segmented motors, whose production is enabled by SPARK, meet the needs of motors manufacturers for reduction of waste material in production, due to cost and environmental concerns. SPARK strongly supports the EC Societal Challenges for clean, efficient energy, environment, resource efficiency and raw materials. Segmented motors, in fact, reduce wastes and therefore energy, CO2 and pollution for material recycling and re-processing.The feasibility assessment will focus on the production process and machinery; the goal is twofold: the technical feasibility (to assess what are the necessary developments to be carried out and including an IP regime analysis) and the economic viability (a detailed Business Plan will be built around the 9 classic blocks of Canvas). This would allow to consider the additional funding that will be needed, with a possibility to further develop the concept through a Phase 2 project.Overcoming the technical barriers in manufacturing these motors, implementing an advanced manufacturing process and introducing the related machinery in our product portfolio by end of 2017 is our major objective. If we succeed in developing this, we would be the only company providing this solution, anticipating compet