RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Doctoral Network on Interfacial Water in Membrane Transport' (WATER).

assistant: **Innovation**

Water is essential to life. 70% of the water in cells belongs to the hydration shells of proteins, lipid membranes or occupies protein cavities - so-called interfacial water. The difference in structure between interfacial water and bulk water gives rise to a key force in molecular biology: hydrophobic attraction. We do not fully understand how exactly this force contributes to protein folding, stability, structure, function, dynamics or membrane fusion.WATER aims to train 16 PhD students to unravel the multiple roles of interfacial water in biological membranes. They will characterise water mobility and ordering inside membrane receptors, carrier proteins and channels, adjacent to their ligands and lipid bilayers, and in the reaction centres of membrane-bound enzymes, using a broad methodological spectrum including cryo-electron microscopy, simulations, light-spectroscopy and imaging. To assess the functional consequences of water confinement, they will analyze facilitated water and solute transport, chemical reactions inside proteins, ligand-protein interactions, the intraprotein H-bond network, and membrane fusion events, exploiting, e.g., electrophysiology and synthetic chemistry. The results will pave the way for the development of personalised, targeted therapies and more effective drugs and vaccines through improved binding and delivery. Biotechnological applications include artificial channels in biomimetic applications.WATER will bring together world-class theoreticians, experimentalists and computational scientists to provide multidisciplinary training in biophysics, molecular biology, medicinal and organic chemistry, structural and synthetic biology, advanced microscopy and computer science. Besides scientific excellence, WATER offers a cross-sectoral approac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sensory information processing impairments following prenatal cannabis exposure: focusing on noradrenaline to move towards early and sex-tailored therapeutic strategies' (SPICE-FONTS).

assistant: **Concept**

How we experience the world is fundamental to survival and guides our behavior from completing a simple motor task to forming relationships. Perhaps unsurprisingly, the inability to filter out sensory information, a function termed sensorimotor gating, is an early and transversal endophenotype for diverse neuropsychiatric disorders. Nevertheless, research on the mechanisms linking maladaptive information processing and psychopathology is surprisingly lacking. According to epidemiological data, prenatal cannabis exposure (PCE) is a predictive risk factor for sensorimotor gating deficits. Notably, a rat model of PCE was able to (1) show that only preadolescent males display impaired sensorimotor gating functions upon subsequent “hits” (e.g. acute stress), and (2) associate this at-risk endophenotype with aberrant dopamine (DA) signalling in the mesolimbic pathway, which stretches from the ventral tegmental area (VTA) to the nucleus accumbens shell (NAcS). Remarkably, females do not show any of these alterations. One proposed gate towards these sex-dependent vulnerable and resilient phenotypes is the locus coeruleus (LC), the major source of noradrenaline (NA) in the brain and a key regulator of the stress response. Indeed, the LC, besides being a sexually dimorphic nucleus, is known to innervate the VTA and influence the mesolimbic DA pathway, including transmission in the NAcS. Nevertheless, the implication of LC→VTA NA inputs in the context of sensorimotor gating has never been investigated. The current project proposes to employ state-of-the-art neurobiological techniques to test with unprecedented precision and resolution the overarching hypothesis that the LC NA system exerts a sex-dependent regulatory role onto VTA DA functioning in the context of sensory informatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Understading the Maize Epigenome and its Role in Development' in the context of a Horizon 2020 call.

assistant: **Objectives**

Phenotypes are largely determined by genetic factors. However, a given genotype can give rise to very distinct phenotypes, as exemplified by the diversity of cell types in multicellular organisms. This phenotypic plasticity results from epigenetic changes; that is, reversible modifications to the DNA molecule and its associated proteins that modulate gene expression patterns. Epigenetic changes are critical to the establishment of developmental programs, but also to adjust transcription in response to the environment. The latter is particularly important for plant adaptation: owing to a sessile (immobile) lifestyle, plants cannot run away from adversity, and thus adapt to their environment by tuning gene expression in response to changing conditions. Most epigenetic information is erased from one generation to the next, so that new organisms start their life cycle with a “fresh” potential. However, there are instances in nature of heritable epigenetic marks that can be transmitted to the next generation. Thus, owing to their role in shaping gene expression, and the potential for heritable changes, epigenetic factors are of great interest for plant breeders, in their quest for adaptable, high yielding phenotypes. Most of our current understanding of epigenetic processes in plants has been developed in Arabidopsis, a key model system. However, the Arabidopsis epigenome is rather idiosyncratic, and this knowledge might translate poorly to crops. Here, we will use an interdisciplinary approach combining original genetic materials and bioinformatics to analyze epigenetic regulatory pathways in maize, with a focus on reproductive development. Maize is an important model plant, with a large and dynamic epigenome much more typical of crops. It is also a crop of great economic i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Unerstanding and predicting the Resilience of marine ecosystems' (ROMANCE), addressing dissemination and exploitation.

assistant: **Impact**

The impacts of climate change are now more pervasive than ever before in human history. Marine ecosystems have been particularly impacted by climate change, with several of them being at the brink of collapse. As a response, the international efforts to reduce carbon emissions have never been so ambitious. However, even in the most optimistic CO2 emission scenarios, the planet will continue to warm and experience the effects of climate change over the coming decades. For this reason, several international conservation targets have been set to maintain the resilience of marine ecosystems to climate change. Despite these calls, resilience research has been hampered by a lack of coherent ways to quantify it and the limited availability of empirical data.ROMANCE overcomes these limitations by taking an interdisciplinary approach to understand and predict the resilience of threatened Mediterranean marine ecosystems to current and future climate change. More specifically, in ROMANCE I will (1) study the resilience of marine communities to past marine heatwaves, (2) develop a deep algorithm to detect early warning signals of collapse and (3) use cutting-edge to predict the resilience of marine communities to different climate change disturbances. The results arising from ROMANCE will provide relevant information for the application of EU directives, especially related to climate change adaptation and coastal resilience, as well as a great leap for the applicant’s career, with valuable training and high-level publications expected.


**Keywords:** Climate change, Conservation, Corals, Marine Heatwaves, Mediterranean, Regime Shifts, Resilience
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Core sets of outcome measures and definition of improvement for juvenile systemic lupus erythematosus and juvenile dermatomyositis'.

assistant: **Objectives**

Juvenile systemic lupus erythematosus (JSLE), and juvenile dermatomyositis (JDM) are rare conditions associated with substantial morbidity/monetary costs, and with disease- and age-related characteristics, that differentiate them from the analogous adult counterpart.Their treatment is still unsatisfactory and drug efficacy evaluation is hampered by the absence of reliable and standardised measures of disease outcome. Consequently, drug safety and efficacy data tends to be from small, uncontrolled, non-comparable case series.Our goals are:1) to identify a core set of outcome variables for JSLE and JDM, and2) to use the core sets to develop a single definition of improvement for JSLE and JDM, to determine whether individual patients respond adequately to therapy.These goals will be the second effort of a 22 countries European research network called Paediatric Rheumatology International Trials Organisation - PRINTO" created with a grant under the 4 Framework Programme.It is our basic premise that without a wide European involvement these studies will never be conducted."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structural Studies on Focal Adhesions' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Focal adhesions (FA) are gigantic protein complexes whose formation is triggered by integrin ligand activation. FAs represent (1) a sensing platform and anchoring points to the outside environment and, (2) a machinery to transduce this information by initiating signaling pathways for cell growth, survival, migration and polarization. Failure in the regulation of FA leads to developmental defects and contributes to the formation of aggressive cancers. Hence, understanding FA formation is the basis for counteracting these detrimental effects. Recently, mass spectrometry and advanced light microscopy clarified players involved in the FA assembly and implicated sophisticated regulation networks of membranes and actin cytoskeletons in the growth of FAs. However, the molecular mechanisms of FA formation and signaling still remain unclear.We propose to study the molecular mechanisms governing the growth of FA by bottom-up reconstitutions using purified recombinant protein components. We will employ a systematic and hierarchical assembly of the FA machinery on an integrin platform as well as on an actin cytoskeleton in a stepwise fashion. We will use a combination of cutting-edge techniques of hybrid structural biology (cryo-EM and X-ray crystallography), light microscopy and biochemical/biophysical approaches. Our core expertise is cryo-EM, which has emerged as the method of choice to study the molecular mechanisms of (super-)macromolecular assemblies. Furthermore, we will set up a system to observe the behavior of tension-sensitive FA components in the presence of force under cryo-EM. Finally, lessons learned from our biochemical and ultrastructural analysis will be directly transferred and tested in living cells. Using these innovative methods, we will tackle fundamental and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The intelligent online platform for lean packaging eco-design' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

About 80% of all environmental impact in the packaging sector starts with the initial phase of its design since it determines the packaging sustainability. The process of prototyping and validating the packaging design is slow, difficult and costly due to the complex workflow integrating the different players in the final design. There is a need in the rigid packaging industry to accelerate the time to market of eco-designed packages. Currently, there is no solution in the market that offer a lean & agile packaging design while the new EU Circular Economy strategy and eco-consumers demands 100% recyclable or 100% reusable or 100% compostable packages. Our e-pack 3D SaaS (TRL6) is based on an online collaborative platform for the packaging ecosystem, which allows customize packaging directly in 3D and validation at the point of sale through Augmented Reality and 3D printing without 3D software design expertise. 3D click´s team has strong expertise in the packaging industry, AR&AI, packaging design & validation, and Circular Economy. We accelerate the time-to market of new packaging products by 88% by providing digital 3D mock-ups in real time with eco-design criteria. So far, we have raised a total of €450,000 to develop our technology (e.g. VIAGALICIA, WA4STEAM) and been selected to participate in prestigious acceleration programmes such as startupbootcamp Commerce and FIWARE Accelerator. We have strong partnerships with packaging manufacturers, technological centres, designers and brands in Spain (Packaging Cluster, Ecoembes), the Netherlands (Innoleaps, Friesland Campina), and Germany (Nivea) that are interested in testing our prototype up to a market-ready solution. We aim to become the leading company in the packaging sourcing, design and validation market and now w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Health Economic Impact of Population-based Interventions for Prevention of Overweight and Obesity'.

assistant: **Concept**

Overweight and obesity account for one eighth of the disease burden and five percent of health care expenditures in Europe and cause large societal productivity losses. Thus, cost-effective strategies for the prevention of overweight and obesity are urgently needed to assure the financial sustainability of health and social security systems. Population-based interventions (PBIs) that change the social and environmental context are promising strategies, however, robust evidence on their health and economic impact is lacking. This uncertainty might lead to inefficient resource allocation and harm for patients and society. In EcIMPACT, I aim to 1) quantify the real-world causal effect of two policy relevant PBIs on body weight, 2) estimate the causal effect of excess body weight on health and economic outcomes, and 3) model the long-term health and economic impact of PBIs by combining results from Aims 1 and 2. I will do so by combining innovative methods from economics, public health, and epidemiology. Specifically, I will pool data from large cohort studies, surveillance initiatives, and household panels across Europe and use econometric methods that exploit natural policy experiments (Aim 1), link primary and secondary data sources that comprise granular genetic, phenotypic, and socio-economic information and apply cutting-edge Mendelian Randomization techniques (Aim 2), and build a simulation model that integrates those estimated parameters in a novel model type (Aim 3). Synthesizing cutting-edge methods from different academic disciplines, EcIMPACT will provide urgently needed evidence for decision makers on the value of PBIs that will ultimately improve population health. EcIMPACT will advance public health research substantially by showing that combinations of innov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Engaging approaches and services for meaningful climate actions' to be submitted under Horizon Europe.

assistant: **Abstract**

ClearClimate is aimed to create an International, Interdisciplinary, and Intersectoral (“3-i”) for creative scholars with strong theoretical and practical skills, needed to tackle the major challenges of the Climate Information Services (CIS) development. The focus will be on developing staff and partner skills in the areas of user-centred design and behavioural science coupled with improved computational techniques which in turn will offer more appropriate and efficacious CIS solutions. The researchers will upgrade their “soft skills” that will enable them to transfer effectively their knowledge to the productive world, thus fostering the European market to create innovation. These will result from a close partnership between the academy, providing the researchers with up-to-date training and knowledge on cutting-edge research on targeted multidisciplinary topics, and a group of industries, who will complete the competencies of the ERs and ESRs by exposing them to practical and real-life challenges in CIS development. The main domains of interest of the ClearClimate project lie in the interconnected areas of climate change and climate extremes, data visualization, decision sciences, communication, accessibility, eye tracking research methodology and visual attention models, and XAI, which are the most relevant disciplines for the development of the frameworks for effective CIS. Secondments, soft skills training, exploitation of scientific results, dissemination, and public engagement, play also a central role in this network since they are designed to promote the dissemination of excellent research and diffusion of innovation in Europe. The creation of such an international, cross-sectoral, multidisciplinary, and life-long network of ERs and ESRs, trained across sector
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of MODELICA Libraries for ECS and Thermal management architectures' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The goal of this project is the development of Modelica libraries (Dymola compatible) to simulate Electrical Environmental Control System (E-ECS) architectures including thermal management perimeter. The efforts will be focused on developing an optimized model to simulate vapour cycle systems (VCS) and liquid loop systems at both steady state and transient operational conditions. In addition, an appropriate strategy will be adopted to couple the thermal and the electrical environments to achieve an integrated simulation of the complete architecture.E-ECS architectures include different cooling systems and electrical components which will be modelled within this project. The system/components to be modelled are:• Vapour cycle systems (VCS), including compressors, reservoirs, valves, heat exchangers, etc.• Liquid loop systems, including pipes, pumps, cold plates, heat exchangers, liquid and diphasic coolants, etc.• Air cycle systems, including compressors, turbines, air-to-air heat exchangers, fans, sprayers, etc.• Jet pumps• Electrical components, such as power electronics and electrical motors• Wing ice protection systemsA multi-level approach will be considered given the object-oriented nature of Modelica. In general, components will be modelled based on their appropriate governing equations (e.g. conservation law of energy, mass and momentum), needed empirical information (e.g. heat transfer correlations), and needed relevant parameters (e.g. compressor efficiencies). However, the modelling will be carried out considering different levels of detail. For instance, heat exchangers will be modelled from simple lumped approaches (e.g. ε-NTU based) to more detailed distributed approaches (e.g. finite volume method).