RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Hydride and hydrogen transfer activity in enzymatic and nonenzymatic systems through the lens of three-component thermodynamics - study of the role of enzymatic microenvironments', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The crucial step for selective cleavage and formation of C-H bonds is a concerted transfer of proton (PT) and electron(s) (ET): hydrogen atom abstraction (HAA) or hydride transfer (HT). The HAA and HT processes can be employed to various chemical transformations: from activation of inert bonds to reduction of CO2. This approach, however, requires a strict control of the regioselectivity of the reaction. Notably, enzymes - catalysts developed by Nature, are characterised by high activity and selectivity. In this project, we would like to provide insight into the interplay of reaction thermodynamics and sterics given by the microenvironment of prototypical enzymatic active sites (employing HAA or HT as a key step in catalysis) and to decipher which of these effects is more important in enzymatic selectivity.The focal point of the project is the novel three component thermodynamic-based model for reactivity, developed for concerted H+/e abstraction. The model captures the coupled nature of PT and ET by the relative magnitutes of redox potentials and acidity constants of the reactants - their values determine not only the the reaction driving force but also the two novel contributions: asynchronicity and frustration with opposing effects on the barrier for the reaction. An asynchronous process, featuring a large disparity in ET and PT components of the reaction driving force, is more efficient. In contrast, a common large size of these ET and PT components makes HAA more frustrated and hence less effective.Based on this model we would like to look into systems capable of CO2 reduction and C-H bond activation to assess to what extent their reactivity is tweaked by the local conditions given by the enzymatic microenvironment versus the canonical factors affecting enzymatic ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Adaptation of Caenorhabditis elegans technology to express and identify parasite target genes' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

There are about 82 million cattle in the EU, most of which are exposed to infection with gastro-intestinal nematodes at grazing, with resultant, often substantial, impaired production efficiency. The most common and most pathogenic of these nematodes is Ostertagia ostertagi, which infects the abomasum of cattle.Control of O. ostertagi in Europe is based almost exclusively on the use of anthelmintic drugs. However, these drugs have several drawbacks such as the high costs, interference with natural immunity, drug residues in food products and in the environment and the increasing incidence of parasite resistance against the anthelmintics. Vaccination is being considered as the most feasible alternative to anthelmintics.Recently, we identified three excretory-secretory antigens from O. ostertagi which induced practically useful levels of protection (~60% in faecal egg counts) in calves against a homologous infection. Unfortunately, it is practically unfeasible to harvest large quantities of the native antigens for vaccine production on a large scale.The challenge now is to produce these antigens in an immunologically active form using DNA technology. Recombinant versions of several gastrointestinal nematodes antigens, produced in bacteria, yeast or insect cells, have proven to be largely ineffective.Glycan is strongly implicated in protection, is quite unique to nematodes and is predicted to be highly immunogenic. A solution is to develop an expression system in the free-living nematode C. elegans where post-translational modifications closely resemble those found in parasitic nematodes.Focussed work is required to improve the level of expression by investigating the use of different promoters and different sites of expression in C. elegans tissues. This is the primary fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'HYBRID BIOMETHANE PRODUCTION FROM INTEGRATED BIOMASS CONVERSION' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The ongoing decarbonisation of the energy and transport systems is a current challenge in Europe. As the rising prices of fossil natural gas make evident, the need to increase renewable gas capacity is undeniable and goes hand in hand with solving bottlenecks that current biomethane production technologies cannot effectively address. The HYFUELUP project aims to demonstrate a flexible and hybrid pathway for the efficient and cost-effective production of biomethane through thermochemical technologies combined with renewable hydrogen. A complete deployment value chain, including biomethane offtake and distribution, will also be demonstrated to contribute to the market penetration of biomethane in key sectors. Thanks to the broad composition of the consortium, the project will blend market knowledge with advanced academic and industrial perspectives to demonstrate the production of biomethane at scale. First, the flexible conversion of low-grade feedstocks via sorption-enhanced gasification will be validated, coupled with syngas or flue gas clean-up, in a demonstrator at TRL6. Then, a second demonstrator will also validate fluidised-bed methanation of either syngas or flue gas with the dynamic addition of hydrogen at TRL6, before both technologies are integrated into a third demonstrator to produce biomethane at scale and reach TRL7. Together, such developments work toward reaching the impacts of the work programme and lead to relevant changes in action and practice via two well-defined impact pathways (“technological development and adoption”, and “enhancing capacity”) that will ultimately help strengthen the European scientific leadership for the development of a highly competitive renewable gas industry, widen the technology portfolio of biomethane production technologi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Enhancing Large-scale chemical Reactions based on Elementary Kinetics' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

A proof-of-concept software tool for microkinetic model construction, ready for commercialization will be developed starting from an available version of the tool that has been validated in an academic research context.A detailed understanding of the elementary steps involved in large-scale chemical reactions provides several advantages: it may not only lead to a better control of the corresponding processes and, hence, safer operation, it also provides a sound basis for enhanced process design. More particularly in the area of catalysis, material development has typically occurred using trial-and-error procedures. While the number of catalysts that could be evaluated has been augmented by so-called high-throughput techniques, an adequate understanding of the underlying phenomena was still limited. Microkinetic modeling is ideally suited to get a view on these phenomena, as it accounts for all elementary steps in the reaction mechanism without any simplifying assumption.The construction of such microkinetic models and corresponding determination of kinetics and catalyst descriptors is not straightforward and requires dedicated (software) tools. The microkinetic engine (μKE), developed within the ‘Catalytic Reaction Engineering’ research group of the Laboratory for Chemical Technology at Ghent University, is such a unique piece of software to facilitate microkinetic model construction. Without requiring any programming from the end-user, kinetic models based on elementary steps can be developed. It allows identifying the kinetically relevant steps that entail the opportunity to further improve the concerned catalytic materials and, implicitly, also the reactors and processes in which they are employed. The microkinetic engine has been validated against in-house data as w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Improve biorefinery operations through process intensification and new end products'.

assistant: **Objectives**

Building on successful projects and relevant assets from partners and an interdisciplinary approach, BioSPRINT applies process intensification in the context of biorefining operations, so as to improve the efficiency of the purification and conversion of sugars from the hemicelluloses fraction of lignocellulosic biomass and to enable their transformation into new bio-based resins for substituting fossil based polymers in a range of applications. The ultimate objective is to lead to a reduction in operation costs, feedstock and energy resources, greenhouse gas emissions and higher yields, while increasing operation safety, by concentrating on technologies which can intensify processing methods and create an integrated biorefinery concept.  Of particular interest in BioSPRINT is the valorisation of hemicelluloses streams derived from hard wood and straw, from processes employed in the production of paper pulp or biofuels. Such streams are readily available from the pilot or production processes of the projects research and industrial partners (Fraunhofer and UPM). A case study using a stream from Clariant will also be carried out.  With regards to processing technologies, BioSPRINT will focus on 4 activity areas (a) Upstream purification; (b) Catalytic conversion; (c) Downstream purification and (d) Polymerisation. The project will develop and validate an intensified and integrated purification strategy leveraging innovative anti-solvent precipitation and membrane separation methods, novel intensified and integrated catalytic processes for dehydration of C5 and C6 hemicelluloses sugars into monomers, extractive-reaction methods to isolate the reaction products from the reaction medium in situ, heterogeneous catalysts and an intensified polymerisation process for furan-bas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Responses of precambrian life to environmental changes' (PALEONANOLIFE) under Seventh Framework.

assistant: **Objectives**

This multidisciplinary proposal has the objective to enhance our knowledge on the early steps of the evolution of life on Earth by providing a foundation for better deciphering the molecular fossil record as well as the geochemical signals hidden in ancient rocks. Based on the multiscale and multitechnique study of morphologically preserved microorganisms fossilized within ancient siliceous nodules, I propose to chronologically reconcile the evolution of metabolisms of life forms during the Precambrian with the variation of (sea)water paleo-temperatures registered by the silica matrix in which the investigated organic microfossils are embedded.Spatially-resolved information on fossil organic constituent speciation and their structural relationships with the silica matrix will be obtained at the nanometer scale using a unique combination of spectroscopy and microscopy techniques, notably including STXM and TEM. Crucial information on paleo-metabolisms will be obtained from NanoSIMS experiments by measuring the stable H-C-N-S isotope composition of the investigated fossilized objects at the scale of individual cells. In parallel, laboratory experiments will be conducted to better assess the potential isotopic and molecular evolution of organic molecules during the fossilization process. Estimations of water paleo-temperatures – likely corresponding to oceanic paleo-temperatures – will be achieved based on the distribution of the silicon and oxygen isotopic composition of silica closely associated to the fossil cells, measured at the very high spatial resolution of the NanoSIMS. Furthermore, the study of natural proxies will provide a more profound understanding of the significance of the temperature registered by the isotopic compositions of Precambrian cherts. In additio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New embedded Systems arcHItecturE for multi-Layer Dependable solutions', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The nSHIELD project is, at the same time, a complement and an improvement of “pSHIELD”, a pilot project funded in ARTEMIS Call 2009 as the first investigation to build the SHIELD Architectural Framework for SPD. The roadmap proposed in this pilot project aims at addressing Security, Privacy and Dependability (SPD) in the context of Embedded Systems (ESs) as “built in” rather than as “add-on” functionalities, proposing and perceiving with this strategy the first step toward SPD certification for future ES. Within this scope, the role of nSHIELD will be to realize, demonstrate and validate this roadmap.The leading concept is to demonstrate composability of SPD technologies. Starting from current SPD solutions in ESs, the project will develop new technologies and consolidate the ones already explored in pSHIELD in a solid basement that will become the reference milestone for a new generation of “SPD-ready” ESs. SHIELD will approach SPD at 4 different levels: node, network, middleware and overlay. For each level, the state of the art in SPD of single technologies and solutions will be improved and integrated (hardware and communication technologies, cryptography, middleware, smart SPD applications, etc.). The SPD technologies will be enhanced with the composable functionality that are being studied and designed in pSHIELD, in order to fit in the SHIELD architectural framework.To achieve these challenging goals the project aims to create an innovative, modular, composable, expandable and high-dependable architectural framework, concrete tools and common SPD metrics capable of improving the overall SPD level in any specific application domain, with minimum engineering effort. The whole ESs lifecycle will be supported to provide the highest cross-layer and cross-domain levels
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Right to an Open Future?: An Ethnographic study of parents and professionals experiences of the diagnostic and predictive genetic testing of children in the Era of Genomics' (GENETESTINGCHILDREN).

assistant: **Concept**

This project will be an in-depth qualitative study of the practice and social consequences of the diagnostic and predictive genetic testing of children, focusing specifically on the experiences of parents and health professionals.The study will be based a t the Research Centre for Biotechnology, Society and the Environment (BIOGUM) at the University of Hamburg and carried out by Dr. Jacquelyne Luce in cooperation with children's hospitals, clinics and genetic research centres in a multicultural region of Germany.The objectives of this project are to use rich in-depth interview and participant-observation methods to investigate:- how distinctions between diagnostic and predictive testing are made;- what meanings are given to the age of the child at the time of the proposed test; and- the reasons given for the test request, by either parent or professional.In doing so, the project will open up a discussion of current guidelines based on empirical findings, explore the implications of a current proliferation of possible genetic tests following the completion of the Human Genome Project, and address the genetic testing of children for not only healthcare purposes but also current research into the complexities of genomics.Dr. Luce will achieve:- new disciplinary skills in clinical and lab settings;- skill at translating findings into policy recommendations;- German language fluency and cultural competencies; and- advanced leadership and teaching skills.The fellowship will enable Dr. Luce to lead a multi-disciplinary project involving parents, clinicians, geneticists, technicians, and science and medicine students with the support of high profile mentors, further contributing to the identified Community objective of developing ¿scientists¿ critical thinking and responsivenes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of innovative manufacturing technologies for reducing process chain' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

New manufacturing technologies have brought some advantages, lowering the environmental impact and improving the work ambience of the machining processes. Many research efforts have been spent in this way, but unfortunately some of these new technologies have remained without industrial applications. So, for this reason, insufficient advantages have been made in improving the industrial manufacturing process, and the exploitation of results has always been a great problem for the research activity. To overcome these problems, the aim of this project is to set up a whole, high-productive, reliable and quality oriented process; able to increasingly develop the most innovative machining processes, and to fit them in one innovative manufacturing process chain for one component that will be widely used in the automotive industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Imprinted Polymers as Coffee Sensors', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Food quality is a global key priority area where technological advances in terms of quality control have been limited. The aim of the IPCOS Network is to bring innovation to the field of food quality by offering an international, interdisciplinary and intersectorial doctoral training programme that will target the development of chemical sensors, using the molecular imprinting technology, for application in the coffee industry, focusing on three main targets: chlorogenic acids, cafestol and kaurene terpenes, caffeine and its metabolites, all of which have been shown to have an impact on consumers’ health. This project brings together 2 academic teams, 1 large international company, 1 SME and one non-profit research centre of excellent, supported by 4 associated teams, with a very multidisciplinary and multisectorial expertise. The IPCOS training program will require ESRs to work 50% of their time in industry, providing them with a set of unique scientific and transferable skills that will match both public and private sector needs, together with a strong development of innovation and entrepreneurship ethos, therefore considerably enhancing their career perspectives. All researchers will aim to achieve a doctoral degree at the end of their training. As a result of the close collaborative links, IPCOS will strengthen the innovation capacity of universities/research institutes to commercially exploit their research and enhance the research potential and competitiveness of European companies and SMEs.