RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'New NANO-technology based high performance insulation FOAM system for energy efficiency in buildings'.

assistant: **Innovation**

The NANOFOAM project consortium is formed by leading and experienced players in the sector of manufacturing innovative chemical products, engineering nanostructured foams and materials, energy efficiency for the Construction sector, Materials Science and advanced modelling and characterization of material properties and thermo-physical processes.Through the proposed RTD and DEMO project they will:• Develop an innovative high-performing nanostructured polymeric foam, employing a low GWP blowing agent such as CO2 and having a lower thermal conductivity and superior properties (mechanical, fire resistance, moisture/fungi resistance) than commercial insulation products at a competitive price.• Evaluate and test the compliance of this technology with respect to current standards and environmental, health and safety regulations in real scale settings (laboratory rooms or real dwellings).• Assess the full technical, economic and environmental performance of the novel engineered insulation nanofoam for its commercial implementation on the market in new buildings and for retrofitting of old ones.The expected results of the NANOFOAM project have the potential to drastically reduce energy consumption and to decrease CO2 emissions for both new buildings and the renovation of existing assets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Combining supramolecular chemistry, physico-chemical characterization and theoretical modeling to understand multivalent interactions at the cell-hyaluronan matrix interface""' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Multivalent interactions are characterized by the simultaneous binding of multiple ligands on one entity to multiple receptors on another. Multivalency provides the basis for mechanisms of both agonizing and antagonizing biological interactions that are fundamentally different from those available in monovalent systems. Even though multivalent interactions occur broadly in biological systems, they are still poorly understood and assaying them remains a fundamental challenge. In this project, we propose a new approach to reveal the regulatory mechanisms underlying multivalent interactions at cell surfaces. We apply this approach to the investigation of the hydrogel-like matrices that are rich in the polysaccharide hyaluronan (HA) and surround many cell types. The supramolecular organization of the HA-rich matrix and its attachment to the cell surface has been associated to a variety of cellular functions and numerous biological processes, including fertility, inflammation and cancer. Our goal is to understand how multivalent interactions regulate the attachment of HA to the cell surface and the physico-chemical properties of HA-rich matrices, and how these mechanisms are connected to biological functions. To this end, we will develop highly controlled and tunable in vitro model systems that are based on multivalent host-guest interactions. Purpose-designed HA and solid supports will be equipped with host and/or guest functionalities using modern synthetic chemistry. The binding of HA to the supports, and the assembly and physico-chemical properties of HA-rich matrices will be interrogated using a toolbox of surface-sensitive biophysical characterization techniques. Theoretical simulations will help to obtain mechanistic insights into the regulation of multivalent interac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Building a Model Cell to Achieve Control of Cellular Organization' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

A hallmark of profound understanding of the organization of a living cell is the ability to reconstitute essential cellular functionalities from minimal components. To achieve this breakthrough a concerted effort of cell biology, biochemistry and biophysics is required. Our project brings together this expertise to reconstitute the cell’s ability to control the organization of cytoskeletal networks in an artificial ‘Model’ Cell.To achieve a mechanistic understanding of how cell organization is regulated, we will develop methods to manipulate cytoskeletal interactions in space and time and study the effects of such manipulation on functional cytoskeletal organization in the confinement of both artificial systems and cells. We will focus on regulatory interactions at dynamic microtubule plus ends, which play an essential role in cell division, polarization, and migration. Using a combination of in vitro, in vivo, and theoretical approaches, we aim at the following goals:1. Achieve a molecular scale understanding of cooperative and competitive relationships between regulators at microtubule ends, and their effect on microtubule dynamics, microtubule behavior at the cell boundary, and interactions with actin filaments.2. Generate a quantitative understanding of symmetric and polarized positioning of the microtubule cytoskeleton by microtubule-cell boundary interactions during cell division and cell migration.3. Obtain a mechanistic view of microtubule-actin co-organization driven by regulatory effects at microtubule ends, with and without the additional contribution of microtubule-cell boundary interactions, and apply this knowledge to manipulate cell polarization and migration.Synergy between our complementary expertise, tools, infrastructure and local collaboration networ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'EnVIronmenTALly Friendly Aero Engine' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

VITAL will provide a breakthrough in low noise and low emission engine architectures. This breakthrough will be achieved by developing and validating novel light weight and low noise technologies for commercial aircraft engines and thus provides a key step towards achieving the ACARE environmental goals in terms of CO2 and noise. VITAL will design, manufacture and rig test the critical technologies required to achieve this goal: low noise and low weight fan technologies and architectures (direct drive turbo fan and contra-rotating turbo fan), low weight structures for very high bypass ratio engines, more efficient low pressure turbo machinery, advanced low pressure torque shaft and overall engine installation. To complement these technological advances VITAL will provide a techno-economic and environmental risk assessment and accompanying optimiser tool for measuring the impact of engines on the environment as well as their economic impact and make this tool available to all stakeholders via a dissemination activity. VITAL will also take-up the results of on-going research programmes in the field of noise and emissions and will deliver a fully validated, novel technology base together with the roadmap to enable a 20% reduction in CO2 emissions and a 6dB reduction in aircraft engine noise (per certification point) and hence contribute to the full realisation of the ACARE goals by 2020. VITAL will achieve this technology breakthrough by bringing together 53 actors from the European aero-engine industry made up of the leading engine manufacturers, the engine-industry supply chain, key European research institutes and SMEs with specific expertise. The advance and benefits that VITAL will bring to Europe at large in terms of more efficient and environmental-friendly air tran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dissecting the molecular mechanisms of protein glycosylation and glycoprotein trafficking in cereal endosperm' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Plant-derived pharmaceuticals (PDPs) have immense potential to address the economic and capacity limitations of current fermenter-based production technology. Several complex multi-subunit and glycosylated proteins have been produced in transgenic plants, which are safe, convenient and cost-effective for large-scale production. High-biomass leaf and seed crops, such as maize and tobacco, are the most widely used. However, since most clinically-relevant recombinant proteins are glycosylated, one hurdle to the widespread commercial production of therapeutic proteins in plants is the fact that plant N-glycans differ from those found in humans, potentially limiting the therapeutic potential of PDPs. Glyco-engineering, to make plants that generate recombinant glycoproteins with human-like N-glycans is therefore an import goal. Most plant-derived glycoproteins studied thus far have a mix of N-glycans whose profile differs according to species, organ and physiological state. In maize seeds, we have shown that the N-glycans on a recombinant antibody were trimmed extensively, indicating the presence of ENGase activity in the endomembrane system of maize endosperm. In order to realize the greatest benefit from maize as a production system, it is important to characterize this enzymatic activity and the corresponding gene. We propose to utilize transgenic maize lines expressing two marker glycoproteins to monitor ENGase activity and subcellular localization in order to isolate, characterize and clone the ENGase gene. This will help in the development of a maize production system for improved glycoprotein therapeutics with appropriate glycans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Adaptive and smart materials and structures for more efficient vessels' (ADAM4EVE).

assistant: **Innovation**

Materials and structures are called adaptive if they can change certain properties in a predictable manner due to the forces acting on them (passive) or by means of built in actuators (active). Those materials and structures are referred to as smart if they provide best performance when operation circumstances change. The project ADAM4EVE focuses on the development and assessment of applications of such materials and structures in the shipbuilding industry.The types of materials and structures are- adaptable ship hull structures for optimised hydrodynamic properties depending on varying cruise speed,- adaptive materials for noise and vibration damping of ship engines to avoid induction of vibrations into the ship hull and- adaptive outfitting materials that improve ships' serviceability and safety.Technical developments in the project are structured in three groups:- Materials and structures development: Based on available research results and known applications from other industries, adaptive and smart materials and structures will be adopted and further developed in order to make them applicable in the maritime industry.- Solution development: Driven by different shipyards, several application case studies will be performed, in order to achieve customised solutions for particular vessel types and their individual requirements; classification societies will assure that the solutions comply with existing rules and regulations.- Enabling and assessment of technologies: This group of activities provides support to the other ones on the field of testing, assessment of safety as well as economical and ecological impact, and advice for production, operation and dismantling. Due to the novelty of the solutions to be pursued, further development of the required validation meth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Eve – From ‘black box’ to yellow box: full insight technology for chicken hatcheries' to be submitted under Horizon 2020.

assistant: **Abstract**

The EU poultry industry produces 6.6 BN chickens a year for meat and egg production. These chickens are hatched in specialized farms called hatcheries. However, 14% of the incubated eggs never hatches and 6.9% of the produced chickens is unmarketable due to deformities or health problems. Hatcheries are a crucial part in the poultry production chain and early days of a chickens’ live. Nevertheless, the incubation of eggs and hatching of chickens is a poorly monitored process, especially in the light of current advances in sensor and internet technologies. In Ovo, a hightech Dutch startup  - focusing on improving animal welfare and resource efficiency in the poultry industry - is developing a sensors platform for monitoring the hatching process.  With the new platform called Eve, it is for the first time possible to monitor and improve processes in hatcheries by measuring data related to biological processes. By real-time analysis of biological data, it becomes possible to detect flaws and potential problems that until now no one was aware of. Eve is outfitted with cameras and smart sensors for monitoring a large set of biological/microbiological parameters. Early awareness of potential hazards will give breeding specialists in hatcheries the possibility to intervene. This increases production, lowers mortality and morbidity rates and provides higher animal welfare. Research shows a 50% reduction in nonmarketable chicks (improving profitability €375K per hatchery a year), improving resource efficiency (880,000 chicks per hatchery a year) and improving animal welfare (less unnecessary deaths) targeting multiple EU policies, consumer demands and business opportunities. The feasibility study will focus on creation of a business plan. In Ovo was world news when they discover
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The roles of legitimacy and significance in higher education accreditations' (ROLEG-SIG-ACCREDIT) under Seventh Framework.

assistant: **Objectives**

In this study I will assess faculty perceptions of European higher education accreditations’ legitimacy and significance and the extent to which these perceptions influence the ways in which accreditations are actually implemented. My research will also assess the role that other factors such as identification with the school and faculty background have on faculty perceptions’ formation. The main strength of this study is its longitudinal design. I will assess faculty perceptions before and after these accreditations take place. This will allow me to better causally link faculty perceptions, attitudes, and behaviours in relation to the accreditations. The context of the study will be that of accreditations linked to the new European Higher Education Area (EHEA). Within such context, this research aims at: -Assessing quantitatively the mediating role of perceptions of legitimacy and significance in shaping faculty reactions to evaluations. -Testing longitudinally the effects of perceptions on attitudes, and attitudes on implementation behaviours. -Assessing the extent to which different evaluation contexts (more versus less threatening) affect the ways in which other variables such as identification or faculty background impact faculty perceptions of evaluations. Last but not least, my project will also involve an ethnographic study of these accreditations to better understand how faculty experience them in real time. With such ethnographic data I intend to build theory on how faculty make sense of European accreditations at their schools. The qualitative findings obtained with my ethnography will be extremely valuable to complement my quantitative findings on perceptions and attitudes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Online monitoring of pathogens in times of Corona virus, influenza and legionella - eliminating infection risk for 20 million Europeans' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

WHO declared Legionella as the highest health burden of all water borne pathogens - even for our developed European countries. There are thousands of infections with mortality rates between 5%-30%. Due to similar symptoms like with pneumonia or with flu (fever, coughing and diarrhoea, shivers, headache and body aches) presumed numbers of unidentified and unregistered cases are estimated to be much higher.There is no automated and scalable solution on market which allows the continuous monitoring of in-house water quality regarding detection and quantification of legionella. Current solutions are laboratory procedures, e.g. cell cultivation, which are time-consuming, costly and mostly error-prone, e.g. by detecting no viable-but-non-cultivatable infectious legionella cells.To improve the health safety of all Europeans, including 20 million people currently under concrete health risks, we developed a worldwide unique solution for highly accurate and automated detection and quantification of legionella bacteria in water. Moreover, our system is able to give predictions and warnings already BEFORE critical value is reached, enabling counter measures. LegioDetect is easy to use also for non-experts, data is easy to understand and thus, the system is perfectly scalable for the fast growing market of Legionella monitoring. Our system is intended for owners/operators of rental houses, public buildings or buildings of special interest (e.g. hospitals, hotels, baths or swimming pools), for private households, but also for operators of cooling towers.


**Keywords:** Residential buildings, RealEstate Market, Water-borne pathogens, Metering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Functional and regulatory interactions between neurogenin3 and signaling pathways during pancreatic endocrine differentiation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

To date, development of beta-cell replacement therapies for treatment of type 1 and type 2 diabetes is limited by the availability of pancreatic islets from organ donors. Hence, alternative strategies rely on generating and expanding beta-cells in vivo or in vitro from renewable sources such as adult progenitors or stem cells, which can be coaxed to differentiate into beta-cells. However, these strategies, based on the knowledge of in vivo embryonic beta-cell differentiation, are still inefficient. Therefore, a more comprehensive understanding of the signaling pathways required for beta-cell differentiation is necessary to make cell replacement therapies a feasible treatment strategy. Neurogenin3 (neurog3), the first transcription factor expressed in endocrine progenitors, is necessary and sufficient to induce endocrine differentiation. Thus, ectopic expression of neurog3 in cultured duct cells triggers the transcription factor cascade that initiates endocrine differentiation. However, little is known about the interplay between neurog3 and intercellular signaling pathways. The main aim of this proposal is to identify genes regulated by neurog3 that are also involved in intercellular signaling pathways and explore their function in endocrine and beta-cell differentiation. Starting from an ongoing study of neurog3 target genes in duct cells, this proposal will use a variety of molecular biology methods to generate a list of candidate genes based on their expression pattern during pancreas development. These molecules or other components of the pathway will be manipulated in vitro in cultured duct cells and pancreatic explants, and in vivo in mouse models to determine their role in beta-cell differentiation. This proposal will bring the applicant, an expert pancreas biolo