RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Investigating macrophage-nerve crosstalk in homeostasis and post-stroke spontaneous urinary tract infection' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

UTI is one of the most common bacterial infections, affecting >150 million individuals annually, worldwide. Unexpectedly, UTI is also the most common complication after stroke, occurring in up to 40% of patients. This suggests a dysregulation between the bladder and the brain, however this has never been studied. In other mucosal organs, neurons are in direct contact with tissue-resident macrophages and modulate their function during infection. Indeed, stroke causes striking changes to the immune compartment, including macrophages, in peripheral organs. As a result, stroke patients experience increased susceptibility to infection, alongside systemic inflammation, which is associated with neurological decline. In this project, I will investigate bladder macrophages in homeostasis and during acute stroke recovery. I will assess the impact of stroke on bladder immune cell-nerve crosstalk, including bladder macrophages and susceptibility to UTI. Specifically, I hypothesize that changes in macrophage-nerve crosstalk after stroke alters macrophage response to infection, leading to systemic inflammation and subsequent neurological decline. In collaboration with The University of Edinburgh, I will use a model of ischemic stroke in the lab of Dr Laura McCulloch to test this hypothesis. During this project, I will use state-of-the-art technologies such as spatial transcriptomics, 3D-imaging and spectral flow cytometry. Training at the University of Edinburgh, alongside in the host lab, will provide me with a unique set of skills combining the disciplines of immunology, microbiology and neurobiology. The expertise I will acquire in this project are in line with my career goals to become an independent researcher, and provide me with the tools to address a novel question in a large
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Healthcare Alliance for Resourceful Medicines Offensive against Neoplasms in HematologY - Sofia ref.: 116026'.

assistant: **Objectives**

Despite significant recent progress in the field of hematological malignancies (HMs), with increasing survival rates and improvement in quality of life, many children and adults with HMs still die from these disorders or experience disabling complications. Therefore, improvement of health care of HMs is an unmet medical need. Thus, it is important to define and align standard and efficient sets of HMs outcomes to measure and evaluate HM data for clinical decisions, long term risk/benefit profile, reimbursement, value analysis, and clinical trials design. Improving outcome measures and endpoint definitions by taking into account “real-life” data and differences in cross-national healthcare practice will undoubtedly result in an optimized, sustainable and effective treatment delivery, as well as in desirable and innovative accelerated pathways for novel drug availability. All these challenges will be addressed within a pan-EU perspective by HARMONY (Healthcare Alliance for Resourceful Medicines Offensive against Neoplasms in HematologY), a comprehensive public-private European consortium of excellence.HARMONY consortium is made up of 51 partners: 44 participants from 10 European countries and 7 pharmaceutical companies from the EFPIA. HARMONY aims to assemble, assess, connect, and analyze heterogeneous HM patient derived Big Data sets to define sets of outcome indicators that can be used for decision-making by key healthcare stakeholders. The consortium will orchestrate leading experts and working cooperative groups in HMs, European study alliances, pharmaceutical market leaders, patient advocacy groups, HTA and regulatory agencies, to: (i) optimize Europe-wide data collection and create a high-quality HM data repository for further explorative studies; (ii) establish a c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Chemical Looping Combustion CO2-Ready Gas Power' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

Chemical looping combustion (CLC) is a new, indirect combustion process with inherent separation of CO2. The CLC technology uses metal oxide particles for oxygen transfer from combustion air to fuel, thus CO2 is obtained in a separate stream without any ga s separation needed. The partners previous EU-project GRACE successfully demonstrated this new combustion technology for the first time, in more than 100 hours operation, and it was found to be one of the absolute best in the cost evaluation of CCP (CO2 C apture Project).  The process features 100% CO2 capture, a highly concentrated stream of CO2 ready for sequestration, no NOx emissions, and no costs or energy penalties for gas separation. CLC uses well-established boiler technology very similar to cir culating fluidized bed boilers, which also means that costs can be assessed with great accuracy. CLC is estimated to achieve CO2 capture cost reductions of 40 to 50% compared to todays best available technology, namely post combustion amine scrubbing. Critical issues for an up-scaling of CLC to a demonstration phase of 20-50 MWe have been identified and it is the objective of the project to establish and validate solutions to these. The project will: - establish industrial-scale metal oxide particle production including availability of suitable commercial raw materials, and also investigate alternate production paths and effects of gas impurities - extend operational experience in long term tests of particles in available prototype, #gt;1000 hour s - scale up process to 100/200 kWth with advanced features, using existing CFB rig  - extend and verify modelling capability for scale-up  - perform process and technology scale-up to prepare for industrial 20-50 MWe demonstration unit and pro duce update of economic assessme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Tracking the Middle to Upper Palaeolithic transition in the Kermanshah Valley, West Central Zagros Mountains, Iran.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The long history of Palaeolithic research in the Kermanshah Valley has revealed a number of sites associated with the Middle to Epipalaeolithic sequences including well-known site of Warwasi Rockshelter. Despite this importance, our knowledge of the Palaeolithic occupation there and even in Iran is suffering from the lack of a clear, up-to-date and scientific work on stratigraphy, settlement systems/dynamics and accurate absolute dating. To overcome some of these problems, the applicant has conducted a Palaeolithic research project in the Kermanshah Valley. This project includes an intensive survey and test excavations around the Warwasi Rockshelter to provide new evidence on the settlement systems, anatomically modern human demography and the process of cultural changes during the Middle and Upper Palaeolithic. This project has resulted into the discovery of 255 Palaeolithic sites and over 7000 Middle though Epipalaeolithic artefacts recovered from the Kermanshah Valley.  Furthermore, the test excavations in three caves in the area uncovered stratified Middle to Upper Palaeolithic sequences. The MUP-Trans Zagros  aims to identify the ghost lineage between Middle and Upper Paleolithic occupations in one of the key regions in the Middle East by multi-proxy and basic approaches of GIS for settlement systems/dynamics, absolute dates and micromorphology analysis of the newly discovered and excavated sites in the Kermanshah Valley. For these aims, the applicant will be greatly benefited from training and experiences offered by the department of Archaeology & Anthropology at Cambridge University in the interdisciplinary researches on the Eurasian’ Middle to Upper Palaeolithic transition.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'REGional Innovation pOlicy, knowledge Spillovers, Productivity, and INstitutions'.

assistant: **Objectives**

The main aim of the REGIO_SPIN project is that of increasing the capacity of policy makers to design appropriate regional innovation policies in the European Union (EU). Regarding innovation policies, a paradigm shift in regional policy has occurred over the last decade in the EU, bringing innovation at the core of the regional agenda. The availability of Structural Funds, as the instrument for the EU cohesion policy, has provided regions substantial resources for innovation policy. The emphasis on the contextual nature of policy has led towards a differentiated territorial innovation policy approach or place-based policies also in EU regional policy.In fact, regional policies are still far away from being place-based: they are often similar and based on policy imitation of 'best practices’. Furthermore, their effectiveness has been questioned. Some key questions arise: Is the region the optimal scale for innovation policy? Do regions have the necessary institutional capability to manage innovation policy? Are regional institutions learning? According to which criteria policies encouraging University-Industry linkages should be designed? These are questions which go at the hearth of the place-based approach of the EU cohesion policy.The REGIO_SPIN project proposal aims to respond to these questions on the ground of empirical evidence. It will take an interdisciplinary perspective bringing together policy-oriented research with the geography of innovation and system of innovation, and the role of institutions. The empirical analysis, covering the European regions in several countries, is divided into three objectives: i. To explore the relationship between quality of the institutions and innovation policy impact; ii. To explore the extent to which policy leads to institu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cold Rydbergs: photoionization, electronic spectroscopy and electrostatic trapping' (CORYPHEE), addressing dissemination and exploitation.

assistant: **Impact**

Spectroscopic investigation of high (n >>20) molecular Rydberg states below and above the first adiabatic ionization threshold will be carried out with the aims of 1) obtaining fully resolved information on the vibrational, rotational, spin-orbit and hyperfine structures of these highly excited electronic states, 2) characterizing the role of nuclear spins in molecular photoionization, 3) determining the hyperfine structure of fundamental molecular cations at kHz resolution and accuracy by Rydberg series extrapolation, 4) measuring intervals between rovibrational levels of these molecular cations at sub MHz precision, 5) gaining a complete understanding, and providing an adequate description and classification, of angular momentum coupling (including nuclear spins) in high molecular Rydberg states, 6) testing theoretical predictions of the energy level structure of Rydberg molecules by ab initio multichannel quantum defect theory (MQDT) and of the rotational, vibrational and hyperfine levels of molecular cations by ab initio quantum chemistry and QED. The spectroscopic measurements using tunable narrow-band vacuum-ultraviolet and millimeter wave radiation sources will be performed on cold samples in supersonic beams as well as on trapped samples of translationally cold Rydberg atoms and molecules. To this end, our recent approach to trap H atoms in Rydberg states electrostatically (Hogan and Merkt, Phys. Rev. Lett. 100, 043001 (2008)) will be extended to molecules, and the possibility of transfering the trapped species from electrostatic traps to magnetic and optical traps will be explored.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Lindau Nobel Prize Winners Meetings at Lake Constance: Enhancing the outreach of the Interdisciplinary Meeting 2005 to EU member, accession and associated countries' (2002-2006).

assistant: **Innovation**

The Lindau Nobel Prize Winners Meetings are a unique forum bringing together, in the heart of Europe, the world's current and prospective scientific leaders, the minds which will shape the future drive for innovation. They constitute in themselves the core of a uniquely personal and two-way network of excellence.During the Interdisciplinary Lindau Meeting 2005 (26.06-01.07) cutting-edge research is brought closer to more and more young European academics. By treating inherent societal, ethical and intellectual responsibilities contributions to innovation and change are made. The Proposal not only enhances outreach to boost the dialogue between science and society, but its special brain gain initiative also fosters the attractiveness of Europe as a research location.Moreover, the Proposal aims to broaden the scope and reach of the Lindau platform now more systematically to embrace all the EU's 25 member countries, the accession countries and the associated countries so as to expand opportunities for interaction and networking with more than 50 of the world's most eminent scientists. On their home ground the brightest and the best of Europe's young academics interact with their peers and their most promising colleagues from the Americas, Asia and Near-Middle East. In the course of their personal encounters in over a week, Nobel Laureates and young scientists jointly develop new ideas and create networks of co-operation and dialogue, to the benefit of scientific progress.An alumni database and net platform allow continuity of dialogue beyond the Meeting. Benevolent support of the Nobel institutions awarding the Nobel Prize contributes to the exceptional status of the Lindau Meetings. The EC support for the Lindau Meetings fosters the EU's standing in science and the divulg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'SAT-Design – A Web Platform for Programmable Self-Assembly'.

assistant: **Concept**

Self-assembly offers a powerful route to create nanostructures with applications in photonics, biotechnology, and advanced materials. Yet, designing building blocks that assemble into a desired target remains a fundamental challenge. Within the ERC Starting Grant SOFTWATER we contributed to the developed the SAT-assembly framework, which reformulates the design of self-assembling systems as a Boolean satisfiability (SAT) problem. This approach enabled the design of colloidal particles with water-like properties and the experimental realization of complex DNA-origami architectures.Despite its success, the current computational workflow is fragmented, non-general, and inaccessible to non-specialists. Algorithms are scattered across research codes, require manual steps such as symmetry detection, and do not support mixtures or arbitrary valences. As a result, the transformative potential of SAT-assembly cannot be widely exploited.The goal of this Proof of Concept project is to develop SAT-Design, a unified and user-friendly platform that generalizes SAT-assembly and makes it broadly available through a web interface. Users will be able to upload target structures, select design constraints, and run the SAT pipeline remotely. The platform will provide both digital solutions (bonding rules, placements, orientations) and DNA-specific outputs (optimized strand sequences for laboratory synthesis).By lowering barriers to entry, SAT-Design will democratize inverse design in self-assembly, accelerate materials discovery, and provide a foundation for industrial exploitation in nanophotonics, biotechnology, and programmable materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '8th International Conference on History of Language Sciences' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The 8th International Conference on the History of Language Sciences (ICHoLS) will take place at the Ecole Normale Supérieure de Fontenay-Saint-Cloud, from Tuesday Sept.14 to Sunday Sept.19 1999, under the patronage of the Société d'Histoire et d'Epistémologie des Sciences du Langage (Society of History and Epistemology of Linguistics) et du Laboratoire d'Histoire des Théories Linguistiques (Laboratory of History of Linguistics) UMR CNRS 7597 Paris 7/Fontenay-Saint-Cloud.This series of international conferences which was held for the first time in Ottawa in 1978, takes place alternatively in Europe (Lille, Trêves, Galway, Oxford) and in America. The conference will be a meeting point for researchers working in the field of the History of Linguistics, a domain currently expanding, numerous learned societies and several scientific journals.In view of the multiplication of national and international meetings, ICHoLS, which gathers periodically about two hundred participants, aim at unifying the international community and at spreading the results of works which are more and more complex.The fact that this conferences takes place in France (for the second time after Lille 1981) signs the crucial and internationaly role played by the Laboratoire d'Histoire des Théories Linguistiques: its researchers are members of the scientific committees of ICHoLS since its creation, of several specialized societies and of scientific committees journals of the domain. It is very important that the conference takes place in the best conditions and the financial help of the European Community is capital.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00080-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Plankton in the Gulf of Cadiz: distribution and control by oceanographic processes'.

assistant: **Objectives**

Coastal management of the Gulf of Cadiz is affected by socio-economic impacts and lack of biological and physical information. The objective of this proposal is to know the variability of the plankton distribution in relation with the oceanographic processes at macro and mesoscale levels.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dissecting synaptotagmin isoform function: from vesicle docking to fusion pore formation' (EXOSYTS) targeting Seventh Framework.

assistant: **Abstract**

Exocytosis is at the base of fundamental physiological processes such as neurotransmission and hormone release and elucidating its molecular mechanisms is a major step towards deciphering the immense complexity of brain function. It is well established that synaptotagmins (syts) are essential components of the release machinery that couple the entry of Ca2+ to the fusion of vesicles and subsequent release of their contents. However, many aspects of syt function, and of the interplay between different syt isoforms, in triggering the release process are as yet unknown. In the present project I propose to investigate the roles of different syt isoforms on exocytosis in chromaffin cells and hippocampal neurons. Since both syt-1 and syt-7 cooperatively participate in exocytosis I will first study the modulation of fusion pore properties by these isoforms. This will be done by studying fusion pore formation through single-spike amperometry in chromaffin cells obtained from syt-1, syt-7 and syt-1/syt-7 knockout mice. I will also virally re-express wild type syts and chimeras between both proteins to identify the domains involved in slow and fast secretion. Additionally, I expect to clarify whether vesicles containing syt-1 and syt-7 are recruited during separate phases of release (fast vs. slow) using constructs that express these isoforms tagged with a pH-sensitive YFP. Finally, I will seek to identify a possible function of syt-7 in hippocampal neurons by first studying its subcellular distribution in vesicles vs plasma membrane. Additionally, I will study whether syt-7 plays a differential role in release between GABAergic and glutamatergic neurons. My proposed multidisciplinary approach offers great potential to tackle these questions and is expected to yield original resu