RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Optimalization of mineral repair Mortars for historic buildings'.

assistant: **Innovation**

During the restoration of historic building much attention is paid to as well t he conservation of the historic materials as the historic shapes. Superficially damaged stones or stones with missing parts are traditionally replaced by newl y carved material. Very often however the original building material is no long er available and thus replacement materials have to be used, which very often a re imported from other countries. These systematic replacements resulted in a s ituation that after the a restoration intervention major parts of the building can be considered as completely new. Since several decades, the use of repa ir mortars becomes more and more popular. Repair mortars are mixtures of bindin g media with granulates. After hardening and eventually reshaping of the surfac e, they mach aesthetically and technically the original material. In this way a ll original material which still is in good condition can be conserved and the intervention can be executed at much lower cost. At the same time, more origina l material is conserved. Products based on slake lime, hydraulic lime, cement, mixtures of lime and cement and of cement and pozzuolana, polyesters, epoxies a re currently commercialized. The purpose of this proposal is twofold: to improv e the quality of an mortar based on zinc oxide and to explore the possibility o f the industrial manufacturing of a repair mortar based on ethyl silicate. The mortar based on zinc oxide has been invented in the 19th century, but due t o a lack of basic research there are still a number of parameters which are unk nown. This research aims to investigate the kinetics of the reaction in order t o allow the manufacturer to improve the quality of his product and due to a bet ter understanding of the chemistry to help him in for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Neon observing school' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The Network of European Observatories in the North (NEON) proposes to focus its light on and favour the development of modern style astronomical observation by organising a yearly observational summer school in active observatories with state of the art optical/IR instrumentation. The School proposes tutorial observations in small groups of 3 students, centred around a small research project, under guidance of a tutor dedicated to each group, and going through all steps of a standard observing run: preparations, observations, calibrations and data reductions. Results have to be presented the last day. A few lecturers that are experts in their field also give necessary fundaments of optics, photometry, spectroscopy, etc. This school is set-up by an initial consortium of three European observatories (Asiago-Italy, Calar Alto-Germany/Spain and Haute Provence-France), with prospects to be enlarged in the future (discussions in the Opticon network). It brings in addition the opportunity to foster collaborative research projects among the participants and to develop among the various contributing astronomers the practical knowledge of available instrumental packages, a necessary step for future co-ordination among observatories. It is open to young researchers from all member states and associated states of European Community.The ultimate goal is to give to the participants the instrumental and observational knowledge necessary for successful applications at the various European observatories and beyond. This is particularly important in the era of space observatories and large 8m telescopes that have to be used with utmost efficiency.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sustainable competitiveness of SMEs in turbulent economic and social environments - a network approach' to be submitted under Seventh Framework.

assistant: **Abstract**

The proposal aims at strengthening research partnerships through staff exchanges and networking activities between 2 European research organisations from Germany and Spain, and 2 research organisations from Argentina and Brazil. The scientific objective is to create a co-evolvement process towards a successful management model for SMEs that combines the European innovation and organizational learning model with Latin American survival strategies in turbulent economies (exemplified by Argentina and Brazil) based on learning networks and clusters.Both, in Europe and Latin America, SMEs are the most important sources of job creation and development in increasingly knowledge based economies.  The economic environment in which SMEs operate, however, have differed significantly until recently. As the turbulence of the global economy is increasing European SMEs will have to learn to remain competitive in this new kind of economic environment.  The answer lies in the development of “dynamic capabilities” of innovating, learning and knowledge management by SME networks.Following established theories and practices of organisational and social learning knowledge research activities are conceived as a joint  learning and co-evolvement cycle in four phases  Creating a joint vision,Learning from European approaches, Co-evolve SME model and practice in Argentina and Brazil,IHarvest and  sustain.To achieve this objective a joint learning and co-evolvement process will be developed by four   international research teams  focusing on 1)Developing dynamic capabilities via SME networks and 2)  via SME clusters , 3)Media + tools for developing dynamic capabilities, 4) monitoring dynamic capability developmentThe proposed project will create 4 major impacts:1. A new understanding of sustaina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Integrated approach to the biological basis of age estimation in commercially important fish species'.

assistant: **Innovation**

Our objective is to develop a fuller understanding of the environmental influences on otolith growth, leading to a new protocol for estimating fish age. Focusing primarily in gadiform otoliths, we will use known-age material to develop artificial neural network models of age.Otolith growth models will be integrated with results from new laboratory and field investigations to improve the objective basis for interpreting seasonal and non-seasonal growth structures. We will work on hake and cod representing a large proportion of the European fisheries in value and volume. As such, this proposal will improve the confidence and reliability of the scientific data used to underpin management of sustainable fisheries.ObjectivesThis project is a co-operative venture to improve our understanding of the biological basis of age estimation for commercial fish species.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel production routes for the fabrication of tailor-made, crystalline, self-structuring oleogels for functional food and pharmaceutical applications' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

One out of five deaths in the EU in 2017 were linked to unhealthy diets and it is estimated that 53% of the EU population is overweight or obese, creating an unsustainable burden on national sanitary systems. Overconsumption of fats, particularly saturated ones, is one of the main causes of obesity; hence promoting diets that are lower in fats is essential. One strategy could be the reformulation of fatty foods with a lower amount of both saturated and total fats. However, this is challenging as fats provide characteristic functional properties that are hard to replicate with different ingredients. The use of oleogels to replace pure fats is a valuable option to solve this difficult task. Oleogels are materials with a reduced content of saturated fatty acids, achieved via the structuring of a liquid oil with a gelator agent. They can be further processed to obtain more complex food ingredients with reduced calories and interesting organoleptic properties (oleocolloids). The application of oleogels is still limited due to several regulatory, technological and environmental limitations. Building on the knowledge gained from the ERC StG grant CryForm, NewOilFactory aims at overcoming these limitations by developing novel manufacturing processes for the production of crystalline oleogels made from sustainable liquid oils, without using hydrogenated fatty acids or expensive gelling agents, and following the mild-processing paradigm. As part of the project these processes will be tested at laboratory scale, optimized using engineering simulation tools and validated in terms of scale-up feasibility, as well as economic and environmental sustainability. In parallel, an evaluation of their market potential and a competitive analysis will be performed. A knowledge transfer strate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Determining the instructive tissue signals and the master transcription factors driving Kupffer cell differentiation' under Horizon 2020.

assistant: **Concept**

We have recently shown that contrary to common hypotheses, circulating monocytes can efficiently differentiate into Kupffer cells (KCs), the liver-resident macrophages. Using self-generated knock-in mice that allow specific KC depletion, we found that monocytes colonize the KC niche in a single wave upon KC depletion and rapidly differentiate into self-maintaining KCs that are transcriptionally and functionally identical to their embryonic counterparts. This implies that: (i) access to the KC niche is tightly regulated, ensuring that monocytes do not differentiate into KCs when the KC niche is full but differentiate very efficiently into KCs upon temporary niche availability, and (ii) imprinting by the KC niche is the dominant factor conferring KC identity. Understanding which cells represent the macrophage niche, which signals produced by these cells imprint the tissue-specific macrophage gene expression profile and through which transcription factors (TxFs) this is mediated is emerging as the next challenge in the field. We here propose an original strategy combining state-of-the-art in silico approaches and unique in vivo transgenic mouse models to tackle this challenge specifically for KCs, the most abundant macrophage in the body. We hypothesize that the liver sinusoidal endothelial cell (LSEC) to which the KC is attached represents the most likely candidate to sense KC loss, recruit new monocytes and drive their differentiation into KCs. Thus, this proposal aims to: (I) determine the TxFs through which the niche imprints KC identity, (II) map the LSEC-KC crosstalk during KC development, (III) generate LSEC-specific knock-in mice to study LSECs in vivo, (IV) demonstrate which LSEC factors influence KC development and function. Importantly, understanding how the KC-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploring the impact of gut microbiota-derived octadecanoids on mucosal healing' under Horizon Europe.

assistant: **Concept**

The microbiota-host crosstalk is crucial for several processes in the gut and its dysregulation is a hallmark of diseases such as colorectal cancer (CRC) and inflammatory bowel disease (IBD). Despite its key relevance for a holistic understanding of human (patho)physiology, how this crosstalk affects the cellular and molecular programs in the intestine remains is yet to be fully understood, mainly due to a lack of suitable technologies and models. It is known that one of the ways that the gut microbiota interacts with the host is via metabolite production. Among these, octadecanoids, lipid mediators from 18-carbon (18-C) polyunsaturated fatty acids, are poorly studied in the context of the gut despite their high abundance and diversity. Studies on this topic have only focused on inflammation, neglecting the mucosal healing response, highly relevant for IBD outcome and CRC tumorigenesis. In GUTMATES, I will use a new zebrafish model of intestinal damage/regeneration- and organoid-based screening platforms, together with murine colitis models, spatial transcriptomics, metabolomics, metagenomics, and clinical readouts to visualize the effect of microbial octadecanoids in intestinal regeneration. This project will provide the first large-scale exploration of how these metabolites modulate the mucosal healing process in vivo, as well as giving a multi-omic atlas of the impact of selected 18-C compounds in the mouse colon during regeneration. My ultimate aim with GUTMATES is to have a comprehensive view of the mucosal healing landscape given by gut microbial octadecanoids, to eventually find compounds or microbes that can be exploited for regeneration-based therapies in IBD and biomarkers for CRC.


**Keywords:** intestinal regeneration, gut microbial metabolites, lipid media
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Food risk communication and consumers' trust in the food supply chain' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The research investigates the antecedents of trust in information sources and risk management along the food chain and the mechanisms that determine the social diffusion of trust. It focuses on the evaluation strategies brought about by consumers to assess the reliability of the message, the way they process risk information with regards to different food hazards, and the cultural gaps between professional risk managers and laypeople. It examines the interplay of the various psychological, sociological, demographic, and economic factors at individual, market, and social level. The proposal aims at providing a better understanding of consumer demands, attitudes and perceptions, with special reference to trust and risk perception in the food chain, and developing better strategies to communicate more effectively to consumers issues surrounding food risk.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'CIrcular SUstainable FLOor coverings' to be submitted under Horizon 2020.

assistant: **Abstract**

CISUFLO aims to set up a systemic framework for circular and sustainable floor coverings (carpets, resilient floor coverings and laminates) and minimise the sector’s total environmental impact. Several challenges exist within flooring to make the transition to a circular economy: (i) complex value chain, varying from country to country; (ii) link to various sectors (construction & building, plastics, textiles & wood); (iii) products cover various raw materials, plus numerous additives; (iv) product lifetimes range from over 20 years (commercial flooring) to 3-4 days (event carpet).CISUFLO provides systemic innovations at the technical, information and socio-economic level and performs 6 pilots to demonstrate their feasibility and value (future flooring, sorting, separation, laminate, vinyl and textile flooring recycling). The basis for circularity is realising circular material streams. Therefore, we focus on the main flooring material streams: wood (laminates), PA (carpets) and PVC (resilient).We aim to realise circularisation via innovations that deliver value along the chain: (i) manufacturing flooring that is easier to remove, re-use, repair & recycle, as a competitive advantage to the manufacturer, and beneficial to several players along the value chain; (ii) integrated product information system enables sorting, but also offers extra functionalities for installation, cleaning and maintenance, and sustainability info for customer at purchasing phase.To engage a broader range of stakeholders and ensure uptake beyond the project we have established a Transition Support Group (TSG) with over 30 members covering technology providers, retailers and collectors.Assuming our impact reaches 30% of the market, CISUFLO will help to shift a turnover of ca. 5 billion to the cir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A New Strategy for Vibronic Spectroscopy of Radicals' (RadSpec) targeting Horizon 2020.

assistant: **Abstract**

This proposal aims to develop a novel strategy for high resolution vibronic spectroscopy of radicals, withunprecedented sensitivity, specificity, and applicability. The proposed scheme will provide answers tolongstanding quantum mechanical questions about non-adiabatic dynamics, and, in combination with aunique, recently developed transparent microreactor source of reactive molecules, enable the pursuit ofunknown reactive intermediates.Radicals and transient reactive intermediates are centrally important to chemistry but notoriously difficultto study. The proposer has recently led several successful experimental and theoretical efforts directedat molecules and transition states thought to be extremely difficult if not impossible to characterize. Herewe propose to launch a revolutionary approach to spectroscopy of these important species, exploiting akey insight into dissociation dynamics on top of elements of state of the art laser spectroscopy techniquesin the infrared, ultraviolet, and vacuum ultraviolet to forge a new universal method. It possesses the highsensitivity and mass selectivity of ion detection, while simultaneously being multidimensional and fullyrovibronic in scope to extract the maximum possible information about coupled nuclear and electronicdynamics.We anticipate that this advance will also be of great interest and utility to a broad swath of researchersin related fields, such as combustion, atmospheric chemistry, and surface science, who require the abilityto track rare but reactive species. The nitrate and cyclopentadienyl radicals will initially be targeted asparticularly important examples, and we also plan to hunt for as yet unobserved reactive intermediatesusing our new spectroscopic scheme alongside the flexibility of our molecular source to ra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Isolating tuple1 homologues from fugu and drosophila'.

assistant: **Innovation**

TUPLE1 is a putative transcriptional factor which has been isolated from the DiGeorge critical region. Haploinsuffiency for TUPLE1 could be partly responsible for DGS and related abnormalities. TUPLE1 is highly conserved across many species including mammals, tish and insects. The work I propose is to isolate TUPLE1 homologues from Fugu (puffer fish) and Drosophila. This approach will allow the identification of conserved or functional motifs. The human TUPLE1 cDNA has been isolated and sequenced. The complete gene structure and flanking regions of the Fugu TUPLE1 homologue will be determined by sequencing from genomic DNA then the sequence will be compared with the human gene. A similar analysis will be done in Drosophila. Conserved elements between the species will provide clues to the functional relevance of particular motifs and provide a basis on which to begin experiments to determine function. Comparisons among species may identify important conserved features in the promoter and upstream flanking region of TUPLE1 which could be the first candidates for mutagenesis studies using Drosophila as a model system. In addition, with the isolation of TUPLE1 from the fish and fly we can compare the evolution of TUPLE1 in human, mouse, chick, fish, frog, fly and yeast.