RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Discovering chronic inflammation biomarkers that define key stages in the Healthy-to-NASH (non-alcoholic steatohepatitis) transition to inform early prevention and treatment strategies' in the context of a Horizon Europe call.

assistant: **Objectives**

Non-alcoholic fatty liver disease (NAFLD) is a multifactorial chronic inflammatory disease that is prevalent in 1 of 4 individuals with a significant personal, socioeconomic and healthcare burden, especially at the later, more severe inflammatory stage of disease - non-alcoholic steatohepatitis (NASH). Despite the severe negative impact of the disease on society, NAFLD remains difficult to diagnose and treat. Additionally, the molecular mechanisms underlying the transition from health to fatty liver to NASH remain poorly understood due to the lack of models that faithfully reflect the complexity of human disease. Hence, Halt-RONIN aims to uncover the early triggers of disease initiation and complex mechanistic drivers of disease progression by implementing a systems biology approach with integrative disease modelling resulting in opportunities for the improvement of the existing detection methods, providing a blueprint to inform personalized intervention strategies and drug discovery for NAFLD. To achieve this goal, Halt-RONIN will combine experimental data from advanced in vitro and in vivo models with multimodal data from extensive human NAFLD cohorts and biobanks and use in silico machine learning approaches, to discover new biomarkers and molecular targets specific to each stage of the health-to-disease transition. By validating preclinical experimental findings with real-world data, RONIN will allow for the discovery of novel biomarkers and molecular targets that are specific to the individual patient’s pathology. Consequently, healthcare professionals will gain the tools and knowledge required to diagnose and establish guidelines for the prevention and treatment of inflammation-driven health to disease. As such, in the long-term RONIN will decrease the number of N
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Co-construction of the Health Promoting Sports Clubs-Policy Audit Tool'.

assistant: **Innovation**

Currently, 12% of European citizens participate in organised sport weekly. Scientists and policy makers have underlined that the potential of sports clubs to promote health has been underutilized, limiting its contribution to society. Beyond the promotion of physical activity, sports clubs can also promote social, mental and physical health and well-being among its participants, as well as playing an active role in sustainable development. With the increase of unstructured sports practices (individuals practicing on their own), sports clubs need to reinvent themselves, in regard to the services they offer to their participants and society. Previous studies have identified sports clubs’ policies as a key determinant in health promotion efforts, but these have been acknowledged by sports clubs managers and coaches as their biggest weakness, across European countries. My knowledge in shaping the theoretical model of health promoting sports clubs and implementing health promoting interventions in sport, will combine with Professor Woods’ experience in physical activity policies framing and implementation to generate a health promoting sports clubs’ policies analysis tool (HPSC-PAT). Three research objectives will contribute to this aim: (1) document policies of sports clubs having participated in a unique health promotion program: the “Healthy Clubs” initiative of the Gaelic Athletic Association, (2) identify how national to local health and sport policies are known and implemented by sports clubs and (3) co-construct a policy analysis tool with sports clubs’ stakeholders. The provision of the HPSC-PAT for sports and health professionals will support sports clubs in their engagement of EU policies on the potential of sport to serve the society by developing health promotion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Development of Continue, Intelligent, Autonomous, Real Time Monitoring the Alarming System for Radon Detection in Water'.

assistant: **Innovation**

Surveys of radon levels in air have been carried out throughout Europe to determine the magnitude of average exposures and to identify situations where excessive exposures occur. At present, specialists can use several types of apparatus based on different detectors, for measuring radon in air and providing spot, integrated or continuous measurements. In contrast, there are few techniques for measuring radon in water, and practically none provide continuous measurements in this medium and a very few works have been carried out. The proposed project involves the development of a real time, automated and continuous radon detection in water, monitoring and alarming system under full computer Supervision. It will be efficiently used either after site remediation or as a warning system on endangered, or potentially to be contaminated sites.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Modeling and Simulation of the Impact of Public Policies on SMEs' under Seventh Framework.

assistant: **Concept**

The aim of the project is to develop a user-friendly policy simulation system allowing forecasting and visualizing the socio-economic potential impact of public policies. This will allow policy makers to make experiments with different socio-economic designs, with the participation of citizens and potentially impacted stakeholders, before a public policy is settled. It will also allow the different stakeholders to participate into the process and better understand different scenarios possible and their side effects.Focus will be set on SME-oriented policies in order to manage the scope of R&D activities. They have been selected given the importance of SMEs in EU Economy, and the R&D potential given by the nature of policies and impacts addressing this collective.Combining suitable data, models, artificial intelligence and interactive visualization tools, the final goal is to develop a policy wind tunnel". MOSIPS system will be suited to craft policy options, giving social and economic stakeholders a decision arena visualizing and illustrating policy insights, providing valuable decision-support, as it will make counter-intuitive feedback, cascading and side effects understandable.MOSIPS will be able to significantly improve the quality of policies implemented by public authorities at any administrative level, and at the same time, facilitate access to meaningful information to citizens about the expected consequences of policies designed for the region/locality/country/area they live at, promoting their engagement and active participation in the policy-making and implementation process.Concrete S&T objectives are related to the consecution of this project aim, mainly dealing with the areas of modelling, multi-agent based intelligent and dynamic simulation, visual techno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'FAST SEMI-ANALYTIC MULTISCALE METHODS FOR MULTISCALE ELLIPTIC PROBLEMS' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The goal of this research is to merge state of the art developments in homogenization theory with multilevel discretization and solution techniques for elliptic equations. Complex multiscale problems are integral part of modeling and numerical simulations in a number of engineering, environmental and biomedical sciences. These problems have physical phenomena in hierarchical structures with multiple, poorly separated length scales. This can result in very large discretizations, which often require advanced supercomputing equipment. Today’s supercomputers, however, allow a limited number of high fidelity simulations. We propose to develop fast semi-analytic methods for multiscale simulations of elliptic systems, when the media has poor scale separation. The key idea is to incorporate analytical approximation of fine-scale local solutions into multilevel methods. These solutions, currently developed for scalar elliptic equation, have been used to approximate both the cell solution of classical homogenization as well as to compute upscaled tensor coefficients. By incorporating those in multilevel iterations on can achieve considerable computational savings compared to state of the art numerical multiscale techniques. The approximations to the fine-scale cell solution will allow to implement both efficient and accurate prolongation operators from coarse to fine levels, as well as coarsening strategies involving the analytical effective tensor coefficient. The procedure will then be extended to the elasticity operator, targeting biomedical applications, such as simulations of bone tissue, relevant to osteoporosis disease. Similar procedure can be also applied for field scale environmental problems, such as carbon sequestration. The expected transfer of knowledge in the area
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High-Impact Injection Moulding Platform for mass-production of 3D and/or large micro-structured surfaces with Antimicrobial, Self-cleaning, Anti-scratch, Anti-squeak and Aesthetic functionalities' in the context of a Horizon 2020 call.

assistant: **Objectives**

Nobel Prize winner W. E. Pauli warned, “God made the bulk, surfaces were invented by the Devil”. Surface properties must be controlled and modified to satisfy demanding engineering requirements for sectors as diverse as consumer appliances, packaging, automotive, aerospace, and energy. The mass manufacture of functional surfaces is currently achieved via the application of expensive coatings, which can have proven harmful consequences on the environment. HIMALAIA proposes the first up-scalable, adaptable, industrially relevant, cost-effective manufacturing platform that would allow the mass-production of high-performing functional micron and sub-micron structured surfaces on 3D and/or large polymer parts with antimicrobial, anti-scratch, anti-squeak, self-cleaning and aesthetic properties without coatings. Latest advances in laser surface patterning/texturing, particle self-assembly for photonic nanojet patterning, and surface  engineering of injection moulds at TRL4 will be combined and brought to TRL6 for the efficient and flexible micro / nano-structuration of large, 3D mould cavities. These moulds will allow mass production of parts with functional surfaces via injection moulding. This process will be developed with great strides made notably on the modelling of structure-function relationships and on the demoulding step. Finally, in-line, model-based inspection of surface topographies and functionalities will be developed and implemented on the platform. Results will be supported by Life-Cycle Analysis, project management, dissemination and IP/innovation management to ensure the economic sustainability and the European deployment of the platform towards 2030.HIMALAIA will validate the efficiency and flexibility of the manufacturing platform through three high impac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Conformational Shift Inducers (CSI): An atomistic level investigation of Aurora kinase A (AurkA)–MYC interaction and its distortion by CSI compounds' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In recent years, remarkable advances in cancer research and treatment have been made. Still, little progress is observed in the treatment of specific solid tumours, e.g. hepatocellular carcinoma. The oncoprotein MYC is frequently involved in the genesis and maintenance of human solid tumours and therefore represents a highly promising drug target. Unfortunately, as MYC does not withhold any potential binding cavities for druglike small-molecules, it has been long considered as an undruggable protein. Recently, however, a potential way to target this oncogene indirectly via Aurora kinase A (AurkA) was introduced. When bound to MYC, AurkA shields it from proteasomal degradation. Specific AurkA inhibitors that are conformational shift inducers (CSIs) prevent MYC binding to AurkA, finally leading to MYC’s proteasomal degradation. This type of inhibition holds a great promise for indirectly targeting MYC. However, the precise mechanism of AurkA–MYC binding is unknown and it is unclear what the most important characteristics of a CSI compound in preventing this protein–protein interaction are. These uncertainties are currently the limiting step in the compound design process and hinder the ongoing drug development. To this end, this research project aims to characterize and study the AurkA–MYC interaction and CSI compounds’ binding to AurkA by long-timescale all-atom molecular dynamics (MD) simulations. The main objectives of this research are to understand the AurkA–MYC interaction on the molecular level and to provide a mechanistic explanation of why the CSI compounds prevent the MYC binding. As a result, this research will guide the design and development of CSIs and thus may provide therapeutic possibilities for cancers with inadequate treatment options. Finally, this wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Engineering soft microdevices for the mechanical characterization and stimulation of microtissues' (MELCART) under Horizon Europe.

assistant: **Objectives**

As living beings move, touch, or grow, the tissues within them are subject to mechanical stresses that act over minutes, hours, or days. These efforts play a critical role at all stages of life, from early embryonic development to homeostasis in adult tissues or disease progression. Mechanobiology has emerged in response to this realization and has led to many discoveries on mechanosensitive pathways in individual cells. However we are still very far from relating the single-cell behavior to the response within a real tissue that contains mixtures of cell types which are organized in complex 3D structures. In this project we will expand mechanobiology to 3D tissues by developing a new class of micro-devices, based on soft robotics and metamaterials, for active mechanical forcing of spheroids and organoids. We will couple this active forcing with multiscale cytometry methods that we have pioneered, in addition to concepts from many-body soft matter physics. This will allow us to understand how the rheological responses of individual cells add up to result in the global tissue rheology. The outcome is a new paradigm to probe phenotypic changes, e.g. the epithelial-mesenchymal transition in a cancer model or the cellular differentiation and 3D organization in a maturing organoid. Conversely we will map how global mechanical stresses are transferred to individual cells that in turn respond to the forces locally. This will allow us to engineer dynamical forcing strategies to guide the biological response of specific populations within a complex co-culture. When applied to developing organoids this will lead to strategies to mature individual cell types, in view of using them for cell therapy. In the case of cancer models we will identify mechanosensitive pathways that can be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Identification of key chemokine-chemokine receptor interactions that control the memory Th2 cells in allergic asthma' (TH2MEMORY) targeting Seventh Framework.

assistant: **Abstract**

Allergic asthma is a disease of airway inflammation caused by an allergic reaction to an antigen. Pathogenic CD4+ T helper type 2 (Th2) cells in lungs are involved in the initiation and perpetuation of the allergic response in airways of asthmatics and animals. Mouse models generated by systemic immunization and respiratory tract exposure with inhaled antigen or by adoptive transfer of effector Th2 cells into naive mice develop eosinophilic inflammation, mucus hypersecretion, and airway hyperreactivity. To mimic disease in asthmatics, we developed a relapsing-remitting mouse model, in we investigate mice during remission and secondary antigen lung challenge induced relapses. Recovered mice are characterized by the presence of Th2 memory lymphocytes in lungs for their lifetime. Exposure of recuperated mice to inhaled allergen reactivates these lung CD4+ Th2 memory cells, consequently initiating disease relapse. The factors governing the survival and retention of CD4+ Th2 cells in the lungs are unknown. One possibility is that memory CD4+ Th2 cells are retained in the lungs by chemokine- chemokine receptor (CKR) interactions. The objective of this project is to identify key chemokine-CKR interactions that control the migration of Th2 cells. We propose specifically, 1) to determine CKR expression on resting CD4+ T cells in the lungs during remission and correlate phenotype with effector function; 2) to identify the critical CKR expression on Th2 cells allowing them to immigrate from the lung during antigen exposure; and 3) to define antigen-specific Th2 cells using a novel transgenic adoptive transfer system. Discovering a reliable phenotype that distinguishes memory Th2 cells in the lungs would allow for their isolation and characterization and potentially lead to new app
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'FUSION OF RADAR & ADS DATA THROUGH TWO WAY DATA LINK' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

In FARAWAY, telematics is seen as a means of enhancing aircraft surveillance and navigation by using a two-way data link. Processing of radar surveillance and aircraft localisation data will employ novel data fusion processors. The project will confirm that the introduction of such links can help safely reduce aircraft minimum separation standards in served and unserved airspace. Broad participation by airlines and aviation authorities is expected to result in a widespread grasp of the purpose, benefits and costs of the application.The Objective is to investigate the enhanced operational performance of ground surveillance and aircraft navigation which are possible through the use of ADS/TWDL (Automatic Dependent Surveillance/Two Way Data Link), using appropriate fusion of ground generated surveillance data with aircraft localisation data to ground by air to ground links.After Operational and Functional Analysis of User and Service Provider requirements, substantial effort will be dedicated to the development of a demonstration site equipped with innovative data fusion processors and data links, with purposely developed avionic ADS/TWDLs carried by a fleet of Airline carriers.It will in particular be verified that in a peripheral airspace interfacing the Mediterranean (Italy) the introduction of ADS/TWDL will provide improved Separation Standards in unserved airspaces and better surveillance standards in areas covered by Primary Surveillance Radar or Secondary Surveillance Radar facilities. Moreover, the TWDL will be demonstrated also in the Swedish airspace and a connection to the Eurocontrol Experimental Centre in Bretigny, France, will make the data available for integration with data generated through the ADS Europe project.This project will contribute to the ADS Med