RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for '2D Conformal mapping of protein surfaces: applications to VIsualization and DOCKing software' (VIDOCK).

assistant: **Innovation**

The goals of structural biology include developing a comprehensive understanding of the molecular shapes and forms embraced by biological macromolecules and extending this knowledge to understand how different molecular architectures are used to perform the chemical reactions that are central to life. Since the first resolution of protein structures by X-ray crystallography and NMR, structural biology seeks to provide this picture of biological phenomena at the molecular and atomic level by analyzing 3D structures. In the present proposal, we propose to change this paradigm by changing the mode of representation of protein surfaces to 2D maps. That will open new avenues for 1. the development of innovative high-throughput computation of protein interactions and relationships and 2. the emergence of new forms of visualization and analysis of protein structures and properties. We will apply this powerful tool of conformal mapping to structural biology by representing protein surfaces that are complex 3D surfaces in 2D conformal maps that we will call positive conformal maps. We will extend this representation by also generating the 2D conformal maps of the negatives of the 3D surface of the proteins. These positive and negative 2D conformal maps of the surface of proteins will constitute a new representation of the protein surfaces that will be the basis for innovative high-throughput and/or interactive simulation methods, visualization methods and more generally that will give an other insight on the structure of proteins. The major impact of this proposal lies in the fact that it will at last open the gates of the long awaited proteome docking. Using a simplified representation of protein surfaces will allow to perform faster complete cross docking calculations and crea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Using chemical-biology to synthesis and study nuclear receptor proteins' (CHEMbioNMR).

assistant: **Concept**

The rapidly growing field of Chemical Biology combines the power of synthetic chemistry with the spectrum of micro- and molecular biology techniques, thus important challenges in medicine can be addressed in revolutionary new ways. This innovative methodology allows problems associated with studying diseases and designing novel drug-like molecules to be tackled in a unique approach. A recent example is the combination of synthetic carbohydrate chemistry with parasite glycobiology that has led to a new candidate for a malaria vaccine. Besides infectious diseases, cancer is a major cause of death worldwide and in Europe 2.4 million cases of cancer are reported per year, 50% of which are fatal.In this proposal we present a chemical biology route to propel research in cancer biology forward so that new drug targets can be identified. This global aim will be achieved by using a multidisciplinary approach, which employs peptide synthesis, molecular biology, NMR spectroscopy, X-ray crystallography and other cutting-edge biophysical techniques.This project, which aims to synthesize different ER modified constructs for elucidating comprehensively the role of post-translational modifications in the development of breast cancer and resistance to tamoxifen, would be of high importance for advancing prevention, early detection, monitoring and treatment of the breast cancer disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nonlocal transport and beam smoothing in laser-plasma interaction' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content The objective of the project is to understand the effects of beam smoothing on SBS and filamentation in realistic 3D. The nonlinear effect of density fluctuations created by the microstructure of the laser beam will be investigated both analytically and using large-scale numerical simulation. This knowledge will give a clear understanding of the life-time and speckle size parameters that can be tolerated, discriminating between ' ' dangerous' ' and ' ' secure ' ' regimes in laser plasma interaction experiments characterized by high convective gain. The most direct application concerns the interpretation of experiments conducted at LULI and similar laboratones around the world. Trainig content (objective, benefit and expected impact) The project builds upon my previous knowledge of plasma kinetic theory and transport, and extends this to include wave-wave coupling and other nonlinear aspects. A significant component of the project involves the use of large scale numencal simulations using state-of-the-art, high performance computers. The large body of expertise at Centre de Physique Theorique in both nonlinear plasma physics and numerical simulation is ideally suited to assist me. The proximity and level of communication between theorists at CPHT and experimentalists from LULI will also allow me to gain command of technologically important areas, such as laser physics, modern optics, and sophisticated |diagnostic tools (required in the interpretation of experimental results and in suggesting new expenments). Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Role of Senescence-associated Cysteine Proteases' (SACP) targeting Seventh Framework.

assistant: **Abstract**

Despite the importance of senescence in world food production and safety, the proteases responsible for the massive protein degradation during senescence have not been identified. Strong candidates for senescence-associated proteases are members of various cysteine protease families that localize in lytic vacuoles that presumably engulf the chloroplast during senescence. This project aims at identifying the proteases that degrade chloroplasts in the model plant Arabidopsis thaliana. To detect and identify the active proteases during senescence the Activity-based Protease Profiling (ABPP) will be applied. ABPP is a novel functional proteomics technology based on the use of labeled small molecule inhibitors that label proteases in an activity-dependent manner. This technology can be used to show where, when and which proteases are active during senescence, and will reveal proteases that act redundantly. The role of these proteases in senescence will be further studied using reverse genetics and cell biological approaches. This project extends on the expertise and interest of the applicant in senescence and provides an excellent interdisciplinary training in cell biology, molecular cloning and state-of-the-art chemical biology. By performing this work in the Plant Chemetics lab at the Max Planck institute for Plant Breeding Research in Cologne, the applicant will have access to one of the best research and training facilities in Europe and leave at the end of the project with the knowledge and materials to establish an independent scientific career.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Engineering of multi-domain protease inhibitors for pest control' to be submitted under Fourth Framework.

assistant: **Abstract**

PROTEASE INHIBITORS provide plants with a natural DEFENSE AGAINST INSECT PREDATORS. They complex with insect gut proteases, when they are ingested and thus prevent the breakdown of plant protein. Insects can not survive when their proteases are effectively inhibited, but it was shown recently that they avoid the adverse effects of protease inhibitors with the expression of protease INHIBITOR-INSENSITIVE PROTEASES. Plant protease inhibitor defense can be made more effective by the transformation of plants with genes encoding protease inhibitors that are specific for the insect enzymes that can not be inhibited by the host plant repertoire. A highly effective cysteine protease inhibitor is the multi-domain inhibitor MULTICYSTATIN FROM POTATO. It has the unique property of spontaneously forming natural protein crystals in the plant cell that are visible by microscope, but its structural properties remain unknown. Its EIGHT NEARLY IDENTICAL REPEATED DOMAINS give it the potential to form large complexes with the insect proteases and increased avidity for the insect cysteine proteases to which it binds. Moreover, its multi-domain structure affords it with better stability against proteolytic breakdown by gut carboxypeptidases. The specificity of this inhibitor in its present form is not suitable, however, to inactivate all cysteine proteases of the Colorado potato beetle - the major insect pest of this crop in Europe - and it is desirable to replace the phytocystatin domains with domains from other sources or to IMPROVE their SPECIFICITY. Our aim is to elucidate the STRUCTURE of the natural 8-domain multicystatin cysteine protease inhibitor from potato in order to understand how it can inhibit 8 molecules of papain simultaneously and to construct similar multi-domain molecule
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sharing and re-using clinical trial data to maximise impact' (SHARE-CTD) under Horizon Europe.

assistant: **Objectives**

Data from clinical trials are a rich source of clinical information, highly structured and clearly explained by the accompanying protocols. Responsible sharing of such data holds incredible promises to increase value and decrease waste in medical research. It is built on principles (ethical, scientific), governance structures, skills, and operation infrastructure. Clinical trial data sharing (CTDS) is an emerging activity in academia as well as in the pharmaceutical industry. Both communities develop models for organising and performing CTDS. Thereby, several issues gain relevance: enhancing data sharing with researchers, improving public access to clinical study information, sharing results with patients participating in clinical trials, certifying procedures for sharing clinical trial information, and reaffirming commitments to publish clinical trial results. We see a developing field of professional activities that need well educated experts to define and implement best practices. Training such a new generation of experts in CTDS requires specific teachings with a focus on clinical trial transparency and reproducible research practices. It should include topics such as clinical trials regulations, ethical, legal, and social issues, informatics, data science, biostatistics, and meta-research, as well as domain expertise across different medical fields. In order to gain a deep understanding of this developing field, research activities should be based on meta-research approaches. Those activities focus on research on best practices for CTDS, developing methods to make efficient use of shared data (e.g., methods to augment randomised clinical trials, perform independent participant data meta-analysis, or estimate personalised treatment effects) and measuring CTDS impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Efficient and rapidly SCAlable EU-wide evidence-driven Pandemic response plans through dynamic Epidemic data assimilation'.

assistant: **Concept**

Pandemics have the potential to disrupt our daily lives and to affect every part of society. SARS-CoV-2 causing COVID-19 disease painfully showed how responding too late, in a fragmented mannar and/or with too little coordination across different sectors and countries, led to huge human and economic costs. ESCAPE’s main objective is to improve efficiency and scalability of early pandemic response plans by providing evidence-based guidelines, standardised research protocols, retrospective insights, and digital solutions that will support scientists in producing and integrating evidence and inform public health authorities in taking decisions to avert or reduce disease and societal burden. The project will provide knowledge and tools that will enhance Europe’s preparedness for a pandemic of pathogen X. These include a science-based blueprint for faster and better decision-making in managing pandemics, tools and frameworks to improve data availability, collection and sharing, as well as advanced analytics and models to understand and project transmission dynamics of pathogen X under candidate response scenarios. ESCAPE will also identify determinants of success and failure in managing pathogen X based on the SARS-CoV-2 pandemic, helping to develop effective response strategies for future pandemics. In addition, the project will contribute to fostering a multi-stakeholder intelligent community allowing improved knowledge sharing and cooperation between policy-makers, the scientific community, the media and the public, ensuring a much more effective response to future pandemics. In the long-term, by improving pandemic preparedness and the effectiveness of response to a pandemic of pathogen X, the project will contribute to reducing health burden and potential negative societ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Non-perturbative aspects of reheating' (1994-1998).

assistant: **Innovation**

Research objectives and content A key problem in inflationary models of cosmology is the mechanism by which ordinary matter is produced from the quantum fields driving the initial exponential expansion - the so-called inflaton fields. It was only recently realised that the energy transfer process may be completely dominated by non-perturbative effects. Numerical and analytical studies of the problem have confirmed that a resonance mechanism closely related to the phenomenon of parametric resonance in classical mechanics can lead to rapid decay of the inflaton. Preliminary investigations suggest that due to the peculiar non-perturbative nature of the mechanism the evolution of the Universe after inflation may be qualitatively different from predictions based on the old theory of reheating. In this project we propose to study in detail,both numerically and analytically, the most important new effects arising from the resonant inflaton decay. These include the possibility of non-thermal phase transitions and the associated production of topological defects, as well as a novel mechanism for GUT baryogenesis. We will also investigate the effectiveness of the resonance mechanism for inflationary models outside the class that has been studied in the literature so far. Training content (objective, benefit and expected impact) Prof. Turok is one of the leading cosmologists in the world and I expect to benefit greatly from his insights into the physics of the early Universe. The proposed project will introduce me to a variety of new analytical and computational techniques that will be important tools in future work. The diverse nature of the physical phenomena under investigation will significantly broaden my knowledge of the field and greatly enhance my ability to select and pur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Photoactive napthalenediimide pi-stacking architectures - Versatile building blocks for zipper assembly of cascade redox gradients' (OMARG) under Seventh Framework.

assistant: **Objectives**

The aim of this proposal is to create smart materials for use in molecular optoelectronics. I will prepare novel oligothiophenes (OT) tethered covalently to blue naphthalenediimides (B). The systems will be constructed such that they will self assemble in a ‘zipper’ like fashion. Synthetic tuning of the OT-B building blocks will allow for the preparation of electronically distinct mulitlayers of different OT-Bs to form gradients down which redox equivalents can flow i.e. a supramolecular n/p-heterojunction (SHJ) which upon irradiation with light will enable light harvesting through rapid gradient mediated charge separation. The question to be addressed is whether the HOMO of OTs are sufficiently high for photoinduced charge separation (PCS) in response to excitation. Hole transfer from B to OT after excitation is essential for construction of supramolecular n/p-heterojunction (SHJ) photosystems, where electrons are transported in stacks of B aligned next to hole-transporting strings of OT. If successively, the problem of how to intergrate blue B chromophores into a SHJ photosystem will be solved. If unsuccessful the OT backbone will be modified synthetically to increase the energy of the HOMO. The subsequent question concerns the compatibility of the OT-B structure with zipper assembly on solid substrates. This will be attempted with the methods established with oligophenylethynyl (OPE-R) and p-oligophenyl (POP-Y) zippers (critical thickness, LBL, QCM controls, etc). Initially, the already available OPE-N initiator will be used. Subsequently the OT-B modules will be integrated into orientated multicolour antiparallel redox gradient supramolecular hetereojunction (OMARG-SHJ) zippers. The OMARG-SHJ zipper will be constructed with red OPE-R (R = red naphthalenediimides) on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Determinants of genetic diversity: Important Factors For Ecosystem Resilience' in the context of a Horizon 2020 call.

assistant: **Objectives**

Genetic diversity – that is, the genomic variation among individuals of a given species – is pivotal for adaptation to environmental alterations and an important factor for ecosystem resilience. Yet, the determinants of genetic diversity remain poorly understood. Population size is often used as a proxy for genetic diversity, but the amount of genetic variation within populations is not always reflected by their population size. Instead, factors such as linked selection, the recombination-, mutation-, and speciation rate, or life history and ecological traits may be more strongly connected to genetic diversity. So far, the interplay of all these parameters has not been empirically investigated, so that their relative contributions to genetic diversity are unknown.In DIFFER!, I propose to thoroughly examine the role of all these potential determinants of genetic diversity by means of combining cutting-edge genomic techniques with a highly suitable model system: the more than 200 endemic cichlid fish species of the East African Lake Tanganyika. Owing to their great morphological and behavioral variation, contrasting speciation rates, and their recent radiation, these fishes offer an ideal framework for comparative analyses. Availability of long-read reference assemblies, recombination maps, a massive dataset of underwater photographs for estimating census population sizes, together with population sequencing of selected species and family-based ‘trio’ sequencing will enable me to investigate specifically the interplay between genetic diversity and (i) life history and ecological traits, (ii) speciation and hybridization rates, and (iii) mutation rates, while at the same time controlling for variation in population size, selection, and recombination.The results of this pro