RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Machine learning for integrated multi-parametric enzyme and bioprocess design'.

assistant: **Concept**

Currently, our world is facing several global challenges like climate change, water pollution, land erosion, resource depletion and unsustainable manufacturing. Biotechnology can provide many solutions to these problems. One example is the development of sustainable bioprocesses, which is at the heart of the EU’s green deal. Enzymes are nature’s catalysts at the core of such transformation since they can catalyse complex biocatalytic reactions. Biocatalysis has been slowly but gradually displacing traditional organic chemistry in several processes by virtue of its better efficacy, with the added value of being less wasteful as evidenced by the cornucopia of EPA Green Chemistry Awards conferred to enzymatic processes. Thanks to protein directed evolution (Nobel Prize 2018), enzyme function can be tailored to new-to-nature industrial conditions within bioreactors. However, there are still many challenges limiting bioprocess scalability, owing to a lack of deep understanding of enzyme function and of efficient strategies to overcome the complex multi-factorial optimisation problem of both enzymes and bioprocesses. To address this gap, also known as the valley of death (i.e., a large investment gap between fundamental and applied research), ELEGANCE will offer a unique educational program combining state-of-the-art experimental and computational approaches including data science and artificial intelligence to design better enzymes and bioprocesses faster. The main goal is to train a new generation of specialists with essential hard and soft skills for transforming biocatalysis into a data-driven discipline to accelerate bioprocess development, thereby anticipating potential challenges arising in the valley of death. ELEGANCE will focus on enzymes catalysing highly selective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'AUTOMATED THERMOGRAPHIC INSPECTION SYSTEM FOR THE INSPECTION OF AERONAUTIC WELDINGS'.

assistant: **Concept**

Thermography opens a new paradigm because shifts actual manual inspections like those of Fluorescent Penetrant Inspection (FPI) into automated inspection and detection to avoid human errors. AUTHENTIC addresses the development and adoption of automated inductive active thermography to improve the probability of detection (POD) of surface defects generated or appearing in welded safety-critical engine components both for in-process control and for final inspection and quality acceptance. The high sensitivity of the technology enables the detection of cracks down to 200 μm. An improvement higher than 50% is expected on the detectable critical defect size, on POD basis.Automation will be implemented during the inspection process through an adequate robotic system and also during the defect detection, characterization and localization, thanks to the developed algorithms. Furthermore, a second sensory will be added to the main system in order to tackle geometrically complex cases where thermography might fail or give a partial result due to accessibility issues. The system developed will provide (i) faster inspections on full-scale components, (ii) elimination of human subjectivity from inspections, and (iii) healthier and cleaner working environment for technicians. The easier, faster and more accurate maintenance inspections will lead to safer aircrafts and to the extension of their lifetime contributing to a globally more innovative, sustainable and competitive EU aircraft industry. AUTHENTIC will cover from the complete definition of the NDT system based on process and inspection requirements to its implementation and validation through the inspection of a real component provided by GKN (topic leader). The achievements of project objectives will be supported by the multi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Three Dimensional Spintronics' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Spintronics, in which both the spin and the charge of the electron are used, is one of the most exciting new disciplines to emerge from nanoscience. The 3SPIN project seeks to open a new research front within spintronics: namely 3-dimensional spintronics, in which magnetic nanostructures are formed into a 3-dimensional interacting network of unrivalled density and hence technological benefit. 3SPIN will explore early-stage science that could underpin 3-dimensional metallic spintronics. The thesis of the project is: that by careful control of the constituent nanostructure properties, a 3-dimensional medium can be created in which a large number of topological solitons can exist. Although hardly studied at all to date, these solitons should be stable at room temperature, extremely compact and easy to manipulate and propagate. This makes them potentially ideal candidates to form the basis of a new spintronics in which the soliton is the basic transport vector instead of electrical current. ¬3.5M of funding is requested to form a new team of 5 researchers who, over a period of 60 months, will perform computer simulations and experimental studies of solitons in 3-dimensional networks of magnetic nanostructures and develop a laboratory demonstrator 3-dimensional memory device using solitons to represent and store data. A high performance electron beam lithography system (cost 1M¬) will be purchased to allow state-of-the-art magnetic nanostructures to be fabricated with perfect control over their magnetic properties, thus allowing the ideal conditions for solitons to be created and controllably manipulated. Outputs from the project will be a complete understanding of the properties of these new objects and a road map charting the next steps for research in the field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer' in the context of a Horizon 2020 call.

assistant: **Objectives**

Cancer is a leading cause of mortality within the aging European population. Therapeutic targeting is hampered by the complexity of the disease, which includes not only molecular changes within the tumor cell itself, but also within its microenvironment. Tumor angiogenesis, tumor-stroma interactions, interactions with immune cells, with the extracellular matrix and cancer stem cell niches allow for malignant cell survival and promote metastasis, the leading cause for cancer-associated mortality. Proteoglycans (PGs) and glycosaminoglycans (GAGs) – structurally diverse carbohydrates of the extracellular matrix and cell surfaces - have emerged as novel biomarkers and molecular players both within tumor cells and their microenvironment, as they integrate signals from growth factors, chemokines and integrins, and cell-cell as well as matrix adhesion. Importantly, their expression is dysregulated in numerous tumor entities, and has been shown to modulate each of the hallmarks of cancer as defined by Hanahan and Weinberg (Cell 2011). We hypothesize that dysregulated function of PGs and GAGs simultaneously affects all molecular steps towards cancer metastasis as a general principle applicable to multiple tumor entities. Pharmacological modulation of their function thus emerges as an attractive multitargeted antitumoral approach which simultaneously acts at multiple levels of disease progression. Besides providing extensive knowledge transfer and training for researchers, the combined expertise of the GLYCANC consortium aims at performing a detailed structural analysis of PG and GAG glycans in disease using state-of-the art methodology, analysing their regulation via epigenetic mechanisms and microRNAs, and elucidating molecular mechanisms underlying aberrant PG and GAG function
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Lignin Biorefinery Approach using Electrochemical Flow' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Liberate represents a powerhouse consortium, including three major multinational chemical companies, Evonik (EO), Perstorp (PER), Oxiris (OXI), SMEs (Chimar, Megara, NX Filtration, Condias, Enso, Idener and gate to growth), four internationally regarded research and technology organisations (ECN, Fraunhofer, Leitat and Sintef), and European leading universities (University of Mainz and University of Alicante). LIBERATE will overcome the technical developments, pilot line scale-up and commercial exploitation barriers of the next generation of biorefineries. Highly efficient and selective anodic electrochemical oxidation will be applied to the depolymerisation of lignin and the synthesis of propyladipic acid from cyclohexanol to deliver a range of biosustainable feedstocks for drop-in replacements or for superior product performance.   Liberate will deliver a pilot-scale electrochemical plant to demonstrate the commercial opportunities of converting low cost lignin feedstocks in high-value biosustainable chemicals. Liberate will model and physically integrate renewable energy sources to deliver a process that is capable of synthesising chemicals with zero CO2. The renewable energy integration will open up new business models for biorefinery operators to utilise peak renewable energy at discounted rates. Liberate will deliver the following benefits:•An electrochemical depolymerisation of kraft lignin to synthesise vanillin with a 7% yield.•An electrochemical depolymerisation of organoslv lignin to synthesise mixed phenolic derivate oligomers with a yield of > 35%.•An electrochemical oxidation of biosustainable cyclohexanol to synthesise proyl adipic acid with a yield of up to 80%. •A biorefinery process capable of accommodating RES fluctuations without loss in efficiency.•
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'What is Tuberculosis? Challenging the Current Paradigm of Tuberculosis Natural History using Mathematical Modelling Techniques' (TBornotTB) under Horizon 2020.

assistant: **Objectives**

What is Tuberculosis (TB)? How does a person go from infection to disease, and what does this mean at the population level? For a disease that has caused over two billion deaths in human history, and is the biggest cause of death from an infection today, the natural history of TB remains stubbornly elusive. In this ERC award I will challenge current paradigms by exploring the implications of new empirical insights from basic science on our understanding of TB epidemiology and its control using mathematical modelling techniques.My hypothesis is that the prevailing paradigm of TB natural history is overly simple, and one of the key drivers of inaccuracy in projections made by mathematical models thus far. Current models of disease typically account for two distinct stages of infection and disease, with mostly one-directional progression between them. Instead, data has shown that individuals experience a range of stages of disease intensity. Moreover, over time individuals can move between stages through a dynamic interplay between immune induced repression and disease progression.In this ERC award I will first focus on collating the best available data to parameterize a new mathematical model of TB with unprecedented flexibility to capture the required trends. I will settle on the best model structure and understand its behavior. In the second stage, I will use the model to explore critical questions in two areas of TB research that require the detail of the new paradigm: the challenge of addressing latent tuberculosis infection; and incorporating the impact of changes in socio-economic indicators on TB trends.The consequences of such a paradigm shift to better reflect new insights from basic science and epidemiology are important. Initial modelling of intermediate diseas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Triage decision making for the elderly in european intensive care units (ELDICUS)' (ELDICUS).

assistant: **Innovation**

Triage decisions for the elderly requiring intensive care units (ICU), trouble patients, families and challenge public authorities. There is an urgent need for more transparency, increased cost-effective access to ICU and a European harmonisation of standards. This project will develop recommendations for public policy by(1) compilation of empirical data by ICU staff in 7 countries;(2) analysis of triage decisions in the elderly resulting in a social map of ethical values, in a cost-efficiency analysis and in a statistical analysis of the benefit parameters of triage decisions integrated with public policy;(3) a valorisation process to finalise the products as European harmonisation of standards. The project will produce a Europe-wide ICU triage scoring system in the elderly. This ambitious project requires collaboration by a consortium of ICU's and specialists in medicine, geriatrics, economics, public health and ethics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Effective methods in rigid and crystalline cohomology' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The purpose of the project is to develop methods for computing with the rigid and crystalline cohomology of varieties over finite fields. The project will focus on two main problems. First, the fast computation of the Galois action. Second, the effective computation of the cycle class map, and the inverse problem of explicitly recovering algebraic cycles from Galois-invariant cohomology classes (c.f. the Tate conjecture). Research on the first problem would be a natural extension of on-going work of the Prinicipal Investigator and others. By contrast the second problem is entirely new, at least in the context of computational number theory. The overall goal of the project is to provide methods and software which will extend the range of application of computational number theory within the mathematical sciences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Secure communication in atm networks' (SCAN) targeting Fourth Framework.

assistant: **Abstract**

Main ObjectiveMultimedia communications and the impressive advances in broadband networking technologies are increasingly influencing everyday life, causing sweeping changes in the way we work, live, and socialise. Confidential communication is of paramount importance for secure multimedia applications such as teleworking, telemedicine, and commercial applications.SCAN addresses confidential communication in asynchronous transfer mode (ATM) networks. The main objective is to develop solutions by applying state-of-the-art encryption on a per-user connection basis, whilst remaining independent of the user application supported by the ATM network and the underlying physical media. The approach is based on developing a secure ATM network interface card (ATM NIC) for PCs that can handle the two different physical media that are commonly used in local area and wide area ATM networks. These cards will operate at transmission speeds in the range from 2Mbit/s to 155Mbit/s. Security services, such as session key negotiation, are an integral part of SCAN.Technical ApproachSCAN approaches confidentiality by encrypting the ATM cell payload on a per virtual connection (per-VC) basis. This conforms to the ATM Forum Security Specification 1.0, which is widely accepted as a framework for secure communication in ATM network environments. The ATM cell stream is intercepted at a well defined, standardised interface, and can be interconnected to the universal test and operations physical interface for ATM (UTOPIA). Both the ATM NIC itself, and a high-speed data encryption standard (DES) - TripleDES hardware unit connected to the ATM NIC via UTOPIA compliant interfaces - are being developed within SCAN together with the necessary software entities such as the security signalling.The SCAN sec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A new paradigm in boosting orphan crops to super grains: Linking metabolomics and gene editing to improve Teff for global food security and sustainable agriculture' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Food security is one of the prime concerns of the world as the production is affected by increase in demand for cereal crops as food and bioenergy resources. In order to maximize productivity, one strategy is to identify and improve indigenous crops (orphan crops) which are often ignored. Orphan crops (e.g. teff, millet) possess better nutritional and adaptive traits than other cereal crops (e.g. rice, wheat). Teff, Ethiopia’s most important indigenous cereal crop is recently gaining attention among farmers and consumers over other cereals due to its natural gluten-free nature and its adaptation to tough environmental conditions. The high market price for its grains and straw make it a valuable cash crop but has received less attention on research and funding. The main objective of “SUPERTEFF” is to apply omics and gene editing strategies for the improvement of teff. The key objectives of the study are (1) characterization of disparate teff germplasm for agronomically important traits using image-based phenomics (2) to explore the nutrient diversity in teff cultivars using high-throughput metabolomics (3) metabolite-genome-wide association studies (m-GWAS) to understand the genotype to phenotype relation (4) to develop a CRISPR/Cas9 gene editing platform in teff with prime focus to lodging. The proposed study will provide a new paradigm in linking metabolic status to gene expression and will provide valid targets for CRISPR gene editing strategies in teff to convert it from an orphan crop to a super crop which will bare comparison to other established cereal crops. The outputs of this project will result in bridging the gap between orphan crops and other cereal crops in terms of sustainable yield and resilience to environmental conditions, whereby addressing the growing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Computational design and prototyping of acoustic metamaterials for tailored insulation of noise' (METACOUSTIC) targeting Horizon 2020.

assistant: **Abstract**

The PoC METACOUSTIC aims at designing (by resorting to the cutting-edge computational modeling and design techniques arisen from the ERC Advanced grant COMP-DES-MAT), prototyping and testing Locally Resonant Acoustic Metamaterial (LRAM) products (panels and liners) for tailored insulation of ambient noise, to be used in building construction, civil engineering, transportation, and other industrial and social environments.The highly innovative solution that METACOUSTIC offers to the market is a breakthrough service providing bespoke soundproofing solutions that meet and exceed the specific soundproofing requirements of customers. It particularly focuses on being able to identify and supress the exact and unique noise spectrum signature that needs to be attenuated. The solution exploits the locally resonant properties of artificially designed microstructures. A locally resonant acoustic metamaterial (LRAM) is able to cancel or attenuate incident sound waves with frequencies close to its natural frequencies, which emerge from its internal structure or topology. The tailored character of the design solutions outcoming from the METACOUSTIC PoC will add dramatic innovation with respect to the existing ones, since specific frequency regions to attenuate can be selected through the topological design of the LRAM, resulting in lightweight products for tailored acoustic insulation.The METACOUSTIC work-plan considers the two types of objectives which drive Proof of Concept projects. One strand of the work is the ‘proof of technical concepts’ line to have assembled the technical excellence to develop and the research findings from the ERC AdG into proven deliverables, ready to begin the transition from lab to commercial application. Equally important is the strand of ‘dissemination