RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DDRNA-based cancer therapy targeted telomeres' to be submitted under Horizon 2020.

assistant: **Abstract**

The so-called “DNA damage response” (DDR) is a coordinated set of evolutionary-conserved events that, triggered upon DNA damage detection, arrests the cell-cycle and attempts DNA repair.  Recently, we have unveiled and reported that DDR activation depends on RNA. We observed that DNA double-strand  breaks (DSBs) trigger the local generation of small non-coding RNAs at the site of DNA damage carrying the sequence surrounding the damaged site. These DDR RNAs (DDRNAs) are essential for DDR activation: removal of DDRNAs by RNAse A treatment of permeabilized cells inhibits DDR activation and DDR can be fully restored by the addition of chemically-synthesized DDRNA carrying the sequence surrounding the damaged site but not other sequences (Francia, Nature 2012). Cancer cells must preserve unlimited proliferative potential. We have previously shown that oncogene activation (and therefore cell transformation) is associated with DDR activation at fragile sites (Di Micco, Nature 2006). Several studies have shown that RNA functions can be inhibited by antisense oligonucleotides (ASO) that act by pairing with target RNAs. We propose scientific development and commercialization activities to bring to a clinical application a therapeutic approach for tumors based on DDRNA inhibition by ASO. Analysis of prior art indicate that there is no overlapping IP protection. Based on our solid IPR, we trust we have an excellent candidate for a first-in-class tool to block proliferation in a subtype of tumors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Making Wind Energy More Bankable…Faster!' (ZephyCloud) targeting Horizon 2020.

assistant: **Abstract**

At Meteopole we set our sights on making the wind energy sector more profitable by maximising the economic value of thewind energy site through optimising wind “quality” and “quantity” and de-risking market and performance uncertainties.Meteopole specialising in wind power optimisation. We realised there was a need in the wind energy sector to provide bothtechnical and technological expertise to an industry suffering from a lack of confidence and reliability. Our ZephyWDG (WindData Generator) and ZephyCDF (Computational Fluid Dynamics) products are currently sold as desktop packages to utilitycompanies, Green Field developers, consultancies, certification bodies and research institutions and banks.These analytical tools reduce uncertainties at each and every stage of a wind project development to ensure that a windfarm project (onshore and offshore) deployment will be profitable with optimum power performance for all key playersmentioned. These industry-proven tools also rectify and optimise performance on existing wind energy projects.However, these tools, in their current format as desktop packages are holding us back and do not give us the benefits ofbeing on the Cloud. This is why need this Phase 1 to carry out a feasibility study and draft a business plan to be full ourambitions to our platform and tools on the Cloud (to offer it as a SaaS to scale-up our products and offer it as a worldwideservice, to offer the platform as Opensource, and to be able to analyse and gather big data to for our customers to be usewhen analysing and evaluating similar “case studies”). We will also define a pricing strategy for our 3 types of users (freeusers who pay for what they calculate), active users who pay an annual fee and also get premium services and academicusers).Together wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Testing the mitochondrial theory of ageing' under Fifth Framework.

assistant: **Concept**

The mitochondria theory of ageing proposes that the accumulation of somatic mutations in mitochondria DNA during life results in a progressive decline in energetic function and eventual cellular and organism senescence. We propose to test this idea directly, by engineering and expressing a version of the mitochondria DNA polymerise POLG that lacks proofreading exonuclease activity, and hence results in the rapid accumulation of medina mutations. This medina matador will be created and tested in parallel in four model systems: yeast, the mouse, cultured human cells and the fruit fly Drosophilae. The phenotypic consequences of an enhanced rate of accumulation of medina mutations will be investigated via studies of cellular bioenergetics function, ageing-related physiological decline and tissue degeneration, alterations in the pattern of gene expression, and overall lifespan.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Peer to peer learning for financing of innovation in the food & bioeconomy' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

The European bioeconomy strategy has estimated that the bioeconomy in Europe has a total value of €2.3 trillion, accounts for 8.2% of the EU's workforce, and  is a central element to the functioning and success of the EU economy. The aim of P2P FINBIO is to enable innovation support institutions and clusters in regions across Europe to quickly and effectively develop new initiatives as well as refine current methodologies to identify SMEs in the bioconomy  with growth potential, to engage with them and assist them through the process of obtaining access to finance, as a means of  maintaining or increasing competitiveness, growth and jobs.The consortium consists of innovation support organisations working within the entire bioeconomy value chain, who recognise the need to learn from each other, to improve the process of assisting SMEs, start-ups and spin-outs with access to finance. The five partners will share the current support services and methods offered to SMEs and will exchange good practices in order to renovate insights and develop a common Design Options Paper. The Design Option Paper will be the result of the peer-review process and will serve as a guide for other innovation agencies interested in implementing the addressed innovation support service. For the best use of the results of the project the goal is set on the possibility to reach as many innovation agencies as possible with the support of the European Association of Regional Development Agencies, EURADA, the Enterprise Europe Network (EEN), as well as clusters working with Bio-based Industries (BBI)


**Keywords:** Bioeconomy, food, finance, funding, venture capital, acceleration, investment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Prevalence and Influence of Sexual Antagonism on Genome Evolution'.

assistant: **Objectives**

Males and females display profound differences in phenotype, physiology and behavior, and understanding the evolutionary forces driving this diversity is a long-standing goal in evolutionary biology. Sexually antagonistic conflict, resulting from traits and/or mutations that are beneficial to one sex but harmful to the other, can in theory lead to strong dimorphism, and has been invoked to explain many evolutionary features, including the large number of genes that acquire sex-biased expression. Quantifying it, however, has proved difficult, and only a few experimental studies have attempted to systematically identify genes under sexual conflict. Species groups with both sexual and asexual populations offer a promising approach to tackle this question, as they allow for a direct comparison of gene expression when selection occurs ½ of the time in females and ½ of the time in males (in sexual species), versus a female-only selective regime (asexual species). Here, we will test the hypothesis that widespread sexual conflict maintains sex-biased gene expression, using the brine shrimp Artemia as a model. Specifically, we will:1. Compare gene expression levels of closely related Artemia sexual and asexual species, to test if the absence of selection on males (in the female-only species) leads to general shifts in expression, and if these changes are consistent with predictions made under sexual antagonism.2. Characterize the Z (sex) chromosome of the sexual and asexual species, to test if this chromosome is particularly prone to maintaining genes under sexual conflict, as predicted by theory.3. Investigate the population genomics profile of genes under sexual conflict, to find signatures of sexual conflict that may be diagnostic for sexually antagonistic genes in other syst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A European Training Program to Foster the Full Therapeutic Potential of Antisense Technology across Tissues' in the context of a Horizon Europe call.

assistant: **Objectives**

The EFFecT Doctoral Training (DN) Network responds to the evolving landscape of RNA-based therapeutics and in particular antisense oligonucleotides (ASO). Over the last 25 years, only 21 antisense nucleic acid-based molecules have been approved by the FDA or/and EMA. However, the field is now at the tipping point of maturity to achieve regular translation from bench to bed side, provided that certain obstacles are successfully addressed. Our consortium involves experts from academia, industry, and non-profit organizations across nine European countries with first-hand experience in the successful translation of this new technology and in-depth knowledge of the remaining hurdles for its success. With leading scientists at different career stages, EFFecT’s core is form by nine academic and three industrial partners. EFFecT's objectives include addressing tissue-specific delivery challenges, imparting knowledge on diverse ASO modalities, and creating a roadmap for ASO therapeutics in Europe. The network's composition leverages over 20 years of experience in nucleic acid drug development, and was born from the successful COST Action ""Delivery of Antisense RNA ThERapeutics"" (DARTER). The EFFecT training network ensures a comprehensive education for Doctoral Candidates through knowledge exchange, secondments, research workshops and dissemination. This network is expanded with the collaborations of experts in communication, intellectual property, and open science that will train the DCs in good scientific practices. By addressing training gaps and fostering collaborations, EFFecT is poised to deliver the next generation of experts in this up-and coming field, elevating Europe's visibility and competitiveness in antisense RNA therapeutics.""


**Keywords:** antisense oligonuc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unravelling the chemical-physical principles of life through minimal synthetic cellularity' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

A grand challenge in bottom-up synthetic biology is to design and construct synthetic cells with life-like properties from a minimal number of parts. Achieving this goal would be a major engineering feat and enable an understanding of how living systems work from the perspective of physical chemistry. Towards this, we have exploited bottom-up approaches and generated new insights into the impact of compartmentalization on the thermodynamics and kinetics of incorporated enzyme reactions. Our findings that dynamic coacervation can ignite dormant enzyme reactions provides the conceptual framework for our plan to build sustained out-of-equilibrium synthetic cellular systems. In MinSyn, the aims are to:  1) Define how molecular reaction networks are tuned by compartmentalization. 2) Build minimal synthetic compartments with self-sustained, out-of-equilibrium behaviour. 3) Utilize communication to coordinate reaction networks within populations of cells.   Together, these objectives test our overarching hypothesis that sustained out-of-equilibrium systems can be established by interconnecting three features: molecular reaction networks, compartmentalization and communication. Key to this endeavour is our unique combination of chemical, biochemical and biophysical tools for quantitative characterization of synthetic cellular systems. We are primed to address the major engineering challenge of building sustained out-of-equilibrium synthetic cellular systems and to tackle a central problem in biological sciences: “How do biological cells and tissues sustain life from collections of non-living molecules?” Our interdisciplinary approach will provide novel tools to the community and represents a unique multidisciplinary approach that will ultimately define the chemico-physico param
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The Enriched Primate'.

assistant: **Innovation**

Of 504 primate species currently recognized worldwide, almost half are classified as endangered or critically endangered. Captive breeding is vital for primate conservation, with modern zoos serving a crucial role as ambassadors of endangered species, breeders of populations acting as buffers against extinction, and educators of the general public. However, captive populations may experience welfare issues that also undermine their breeding success. Particularly, zoo management is challenging because of the mismatch between natural and captive environments. The aye-aye (Daubentonia madagascariensis) is the only surviving species of the Daubentoniidae, the oldest family of the living lemurs, one of the 25 most endangered primates in the world, and currently showing a low success rate in captive breeding. This multi-zoo project aims to identify and reproduce the female aye-aye’s fertile chemical signature and then test its effects on the breeding success and welfare of three captive troops. We will meet these goals using methods that integrate cutting-edge semiochemistry with established behavioural observations and faecal endocrinology as well as innovative faecal gut microbiota analysis. This novel project will provide findings which should also entail quantifiable impact, such as best practices adopted by target zoos and extended to other institutions through amendments in management policies released by the Studbook Keeper and the Taxon Advisory Group Coordinator for the study species. The complementary expertise of the Fellow and the supervisory team make this project feasible and highly multidisciplinary. The training provided by the supervisor and the host organisation will contribute significantly to the profile of the Fellow, adding new methodological and scienti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Climate Change and Areas with High Species Diversity at Global Scale'.

assistant: **Objectives**

The aim of this project is to estimate possible climate-induced changes to species richness in three categories, total, endemic and threatened richness.  Possible impacts will be assessed: a) at a global scale; b) for centres of endemism for vascular plants, birds, mammals, amphibian and reptiles; c) in CI global biodiversity hotspots; and d) for the Global 200 ecoregions. In just the same way that Conservation International recognise biodiversity hotspots, by considering the combined effects of land use change and biodiversity value, an aim of the proposed work is to map regions of climate-induced rapid loss in species richness, which will be described as “climatic biodiversity hotspots” (ClimBioHotspots).  Identification of vulnerable to climate change areas, where species extinction for the five taxa and three categories is expected to be highest, requires several steps:  1.  To collect and harmonise databases (biotic, environmental, land use, human population density, climate scenario) 2. To test existing tools and methods, including the species-energy relationship for vascular plants and general dissimilarity models and software, a means of predicting total, endemic and threatened species-richness. 3.  To develop new concepts and statistical models for estimating dissimilarity in intra-taxa congruence. 4.  To carry out computer experiments for assessment of species richness changes for the six climate change scenarios.  5.  To identify regions important for biodiversity that are vulnerable to climate change areas. We expect that our results for climate change induced impacts upon species diversity in the global conservation priority areas and identification of ClimBioHotspots will have a significant response in scientific literature and mass-media. The users in nat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Common agricultural policy strategy for regions, agriculture and trade' under Fifth Framework.

assistant: **Concept**

The project CAP-STRAT aims at Supporting DG-AGRI by projecting the development of the agricultural sector and analysing the impact of current and alternative policy programs through the application of the rationalised modelling system CAPRI. In order to apply the system, its database will be updated, the empirical base of the model specification enhanced, and extensions introduced with respect to envisaged policy scenarios. A reference run will be prepared representing the most probable development of Em's agriculture until 2010. Policy scenarios will be defined, simulated and analysed in co-operation with DG-AGRI. The project mainly relates to point 5.4.2 of the work program of the fifth framework, which states specifically the actions forecasting the development of agriculture, ... identifying the necessary adjustments in the CAP and evaluating the potential impact of policy decisions, the improvement of existing models"."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Geometric Reconstruction And noVel semantIc reunificaTion of culturAl heriTage objEcts' (GRAVITATE) under Horizon 2020.

assistant: **Objectives**

The overall objectives of the GRAVITATE project are to create a set of software tools that will allow archaeologists and curators to reconstruct shattered or broken cultural objects, to identify and re-unify parts of a cultural object that has been separated across collections and to recognise associations between cultural artefacts that will allow new knowledge and understanding of past societies to be inferred. The project involves, as partners, a world-renowned museum, an archaeology institute, and research partners working in the manipulation of 3-D objects, semantic analysis and ICT integration. The project is driven by the needs of the archaeological institutes, exemplified by a pertinent use case, the Salamis collection shared between Cyprus and the British Museum. Expertise in 3-D scanning from previous project experience enables the partners to embark on a programme of geometrical feature extraction and matching on the one hand, and semantic annotation and matching on the other. The integration of these approaches into a single decision support platform, with a full suite of visualisation tools will provide a unique resource for the cultural heritage research community. We anticipate that the insights to be gained from the use of these tools will lead to faster and more accurate reconstruction of cultural heritage objects for study and exhibition, to greater opportunities for reunification of objects between collections and greater insights into relationships between past societies which can be communicated as coherent narratives to the public through new forms of virtual and tangible displays, involving the reconstructed objects themselves as well as 3-D printed objects and digital visualisations.