RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Virtual Design, Virtual Processing and Virtual Testing of Metallic Materials' (VIRMETAL) under Horizon 2020.

assistant: **Objectives**

The project VIRMETAL is aimed at developing multiscale modeling strategies to carry out virtual design, virtual processing and virtual testing of advanced metallic alloys for engineering applications so new materials can be designed, tested and optimized before they are actually manufactured in the laboratory. The focus of the project is on materials engineering i.e. understanding how the structure of the materials develops during processing (virtual processing), the relationship between this structure and the properties (virtual testing) and how to select materials for a given application (virtual design). Multiscale modeling will be tackled using a bottom-up, hierarchical, modeling approach. Modeling efforts will begin with ab initio simulations and bridging of the length and time scales will be accomplished through different multiscale strategies which will encompass the whole range of length and time scales required by virtual design, virtual processing and virtual testing. Nevertheless, not everything can or should be computed and critical experiments are an integral part of the research program for the calibration and validation of the multiscale strategies. The research will be focused on two cast metallic alloys from the Al-Si-Mg and Mg-Al-Zn systems. The expected breakthrough is precisely to demonstrate that the structure and properties of two standard engineering alloys of considerable industrial interest can be obtained from first principles by bridging a cascade of modeling tools at the different length scales. Once this is proven, further research will lead to the continuous expansion of both the number and the capability of multiscale simulation tools, leading to widespread application of Computational Materials Engineering in academia and industry. This w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Role of microRNAs 143 and 145 in cardiovascular physiology and disease: from bench to bedside'.

assistant: **Concept**

Cardiometabolic diseases (CMD) (such as atherosclerosis, hypertension) are the primary cause of death and disability in the Western world. Although lifestyle programmes and therapeutic approaches have significantly reduced the socio-economic burden of CMD, a large number of events still cannot be avoided (residual risk). Neointimal hyperplasia is the principal pathogenic occurrence underlying atherosclerosis, restenosis. The common feature in these disorders is de novo tissue formation in the intimal layer due to inappropriate vascular smooth muscle cell (SMC) proliferation and migration. MicroRNAs (miRs) are short, non-coding RNAs that negatively regulate the proteins expression by binding to the 3’ UTR of target mRNAs. Bioinformatic analysis predicts that each miR may regulate hundreds of targets, suggesting that they might play roles in almost every biological process, including those of the cardiovascular system. Studies are beginning to unravel their fundamental importance in vessel biology. In this grant, we propose to study the role of 2 clustered miRs, miR-143 and -145, in vessel SMC and pericyte biology, and their possible application as biomarkers of vessel diseases and as a therapeutic tool for curing occlusive vasculopathies. These 2 miRs are part of the same bicistronic unit; we previously found that they are particularly expressed in the vasculature and are able to regulate vascular homeostasis and SMC migration and proliferation: thus, their modulation may have clinical implications in the pathogenesis of vessel disease. Previous data revealed that vascular stress is associated with down-regulation of these miRs in SMCs: their modulation was found to be responsible for SMC phenotypic switch from a contractile/non proliferative to a migratory/proliferative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Defining the key requirements for sensing pain using mouse and fruit fly behavioural models and new gene ablation techniques' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Chronic pain affects approximately ten percent of the population. Pain management is therefroe asignificant global concern. However, despite its prevalence, medicine has yet to offer an effectivetherapy for chronic pain.The goal of this proposal is to iden tify novel participants in the mammalian pain detection system, withthe long-term goal of targeting these novel participants to develop new painkillers. Our hypothesis isthat, due to its necessity for survival, the underlying mechanisms involved in sensing and reacting topain will be evolutionarily conserved. We propose to screen a complete Drosophila library to identifyall essential components involved in Drosophila pain detection. Taking this information, we will screenthe mouse genome for murine ortholog ues of these factors. We propose to create murine knockoutsdeficient in these orthologues, and then evaluate the ability of these mice to respond to pain. In micewith an impaired ability to respond to pain, we will use DNA microarrays to characterize the t issue-specific global gene expression patterns in various neuronal and non-neuronal tissues. Completion ofthis project should reveal all conserved mechanisms to sense pain.In addition to elucidating conserved mechanisms for detecting and sensing pain, our proposal attemptsto define a new paradigm for characterizing complex biological processes. We hypothesis that the basicmechanisms nature has selected to organize conserved complex biological processes will have beenafforded less evolutionary leeway. While specific players may have subtly different roles, the structureand conceptual organization of this complex process will be similar. Thus, we believe that invertebratemodels like Drosophila contain clear answers to how many complex mammalian systems areorga nize
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Evolutionary conserved T cells specific for a microbial metabolite: deciphering their development in the thymus and mapping their interactions with the gut microbiota in vivo.'.

assistant: **Objectives**

Mucosal Associated Invariant T cells (MAITs) represent an evolutionary conserved subset that express a semi-invariant TCR recognizing a new class of microbial metabolite antigens presented by the MHC class Ib molecule, MR1. In addition to their wide anti-microbial specificity, the high inter-species conservation of both MR1 and invariant TCR infers an important biological role for MAITs. MAITs are abundant in human blood (1-8 % of T cells), mucosa and liver (20-50%). After development in the thymus, MAITs reach the periphery where they acquire a memory phenotype and expand in a process that requires a commensal flora, indicating that MAITs play a role in host-commensals interactions. Admittedly MAITs blood frequency is modified in several pathologies in which dysbiosis of the gut microbiota has been implicated such as IBD, MS, type 2 diabetes and obesity.MAITs were first described over 15 years ago by the Host lab, but the understanding of their development has remained limited because of their scarcity in laboratory mice. Here we will overcome this challenge by using a new mouse strain with increased frequency of polyclonal MAITs.Using my expertise acquired in the US and building on unique tools, we will:1) Define MAITs lineage: we will use a transcriptomic approach together with dedicated transgenic mouse models to determine how MAITs selection leads to their specific differentiation program in the thymus.2) Elucidate the mechanisms of MAITs peripheral expansion: we will use germ-free mice and modified bacteria to map the in vivo availability of MAITs ligands upon colonization with commensal microbes.The proposal will provide insights into an evolutionary conserved model of interactions between the adaptive immune system and the gut microbiota.By enabling me to perman
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Integrating non-living and living matter via protocellular materials (PCMs) design and synthetic construction' under Horizon Europe.

assistant: **Concept**

The bottom-up construction of synthetic cells or protocells from inanimate molecules and materials is one of the grand challenges of our time. While research thus far has been focused on increasing the biochemical complexity individual protocells, this research proposal intends to pioneer the first scientific advancements towards the controlled assembly of protocell building blocks into forms of adaptive and self-regulating protocellular materials (PCMs) that can integrate with living cells and target their mechanochemical sensory pathways.To achieve this, I am proposing to work at the interface of synthetic chemistry, materials science, microfluidics, and tissue engineering to address the following unprecedented aspects of PCM design and synthetic construction: (1) the engineering of PCMs with mechanical properties that mimic those of soft living tissues; (2) the engineering of PCMs with rudimentary adaptive and self-regulating higher-order behaviours; and (3) the development PCMs capable of interacting and integrating with living cells. I will start by developing the first experimental methodologies to assemble PCMs with a range of elastic moduli that mimic those of soft living tissues from protocells endowed with synthetic polymeric cytoskeletons of different composition. I will then engineer the first adaptive PCMs capable of autonomously converting environmental luminous stimuli into mechanical motions and reconfigurations that will self-regulate their endogenous enzymatic reactivity. Finally, I will develop the first forms of PCMs capable of delivering both mechanical and biochemical cues for living cell spreading, proliferation and differentiation in vitro.Overall, the proposed work will pioneer new internationally leading science at the life/non-life interface t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'To Notch up a broken heart' (STRESSFATE) targeting Seventh Framework.

assistant: **Abstract**

Heart failure is a major health issue and a cause of death and disability. The endogenous regenerative capacity of the heart is too weak to recover from damage and instead the heart repairs damage by synthesis of a scar tissue leading to functional deterioration. To improve cardiac regeneration, stem cell therapies and material-based approaches have been developed but up till now with limited success as we still lack detailed knowledge of and the functional technology to guide the regenerative process. Cardiac tissue is composed of muscle cells, non-muscle cells and extracellular matrix organized into a complex 3-dimensional architecture. The regeneration process requires specialization of cardiac stem cells in combination with remodelling of the extracellular matrix to form a functional contractile tissue. The Notch signalling pathway is a unique therapeutic target for regeneration of the heart, but we no nothing about the crosstalk between Notch and the biomechanical microenvironment. We aim to develop an in vitro model system using in situ differentiation of cardiac stem cells  on 3-dimensional microtissue. The tissue can be engineered to mimic healthy or diseased myocardium tissue and be mechanically stimulated to mimic the beating heart.  Using the model we aim to gain in-depth understanding on how the  extracellular matrix and changes therein and the Notch signalling pathway, are interlinked. To use Notch modulation as a handle in cardiac regeneration we will develop technology for temporally and spatially controlled modulation of Notch signalling and build a prototype of functional scaffold for cardiac stem cell differentiation comprised of controlled delivery of Notch modulators from a synthetic matrix.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Manufacturing quantum advantage via scalable germanium quantum processors' under Horizon Europe.

assistant: **Concept**

Europe faces growing computational challenges that cannot be solved by classical computers, from drug discovery to materials science to cybersecurity. Quantum computing may address these challenges, but we must scale to millions of qubits while maintaining high performance - a goal that has eluded all current approaches.Groove Quantum has pioneered a revolutionary quantum computing platform using holes in germanium as qubits. Our breakthrough innovation combines the manufacturing scalability of classical semiconductors with quantum computational power. We have demonstrated world-leading performance including single-qubit fidelities exceeding 99.99%, two-qubit fidelities above 99.3%, and operation at higher temperatures than competing platforms. Most importantly, our technology has a path to scale to millions of qubits in a compact size using standard semiconductor manufacturing processes.We will complete development of our quantum computing platform for industrial deployment. We will optimize manufacturing processes for consistent high-performance qubits, implement these processes in semiconductor facilities, and begin commercial deployment through both cloud access and on-site systems. Our innovation will establish European leadership in quantum computing while strengthening semiconductor manufacturing capabilities and control of these strategic technologies.Groove’s success will transform multiple industries and provide Europe sovereign access to practical quantum computing capabilities critical for future competitiveness and security.


**Keywords:** quantum computing; quantum technology; fault tolerance; qubits; germanium spin qubits; scalable Fault-tolerant Quantum Computing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrity of welded and weld repaired cast iron components' (1994-1998).

assistant: **Innovation**

Iron castings represent over 80% of total foundry production and provide key components in the automotive powers earthmoving, construction and machine tool industry. As a near-to-net-shape forming technique, casting exhibits the optimum in material economy. Not only is expensive machining minimised but substantial economies in valuable raw material can be realised. At present, however there exists no universal acceptance criteria for the welding of cast iron component, either during production or for weld repair during service. This makes it difficult for producers. mostly SMEs" to specify acceptable weld standards. SME foundries would benefit considerably by reducing production costs. by having the capacity to repair casting defects and users will be able to weld repair failcd or damaged service components in preference to complete renewal. However, in acting individually neither SME producers nor SME users have been able to develop internationally accepted weld procedures for cast iron. primarily due to a lack of R&D facilities and insufficient funds for a major undertaking of this kind. The overall aim of the proposed project is to develop improved and widely accepted procedures for the welding of cast iron. Such a study will benefit both the users of cast iron components and more specifically the foundries that produce them. Overall costs will be reduced as a consequence of lower scrap rates. The existence of accepted procedures is likely to extend the potential application of cast iron. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Upper Austrian Researchers' Night' (OOE-NIGHT), addressing dissemination and exploitation.

assistant: **Impact**

The Upper Austrian Researchers' Night aims to bring the most successful researchers closer to the public in the region of Upper Austria. During the OOE-NIGHT on 26.09.2008 around 60 researchers and scientists will present themselves and their research activities at six different locations in Linz - the capital of Upper Austria. The visitors will have the opportunity to take part in experiments, interactive games and demonstrations and lively discussions with researchers as well. The areas of topics presented range from robotics, art & media, social sciences, philosphy, theology to nanotechnology and many more.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'eUropean naturalistic Driving and Riding for Infrastructure & Vehicle safety and Environment'.

assistant: **Innovation**

Road transport is indispensable for the exchange of goods and persons, but at the same time has severe negative consequences, among others related to road safety and environment. In order to meet EU targets, both the number of road crashes and vehicle emission levels need to be reduced substantially. For identifying the next generation of measures that will enable us to actually reach these targets, a far more in-depth understanding of road user behaviour is needed. The proposed UDRIVE project is building on the experiences of the PROLOGUE feasibility study and various Field Operational Tests (FOTs), and aims to contribute to developing this in-depth knowledge by:1. Conducting a large-scale European Naturalistic Driving (ND) study;2. Building one central database with the collected ND data;3. Performing targeted analyses in the areas of:o crash causation factors and associated risks,o distraction and inattention,o vulnerable road users,o eco-driving;4. Applying the findings in four specific area, notably:o the identification of new and promising countermeasures,o the potential of simple DAS for monitoring performance indicators over time,o the improvement of driver behaviour models for road transport simulation,o the possibilities for commercial applications of ND data;5. Leaving behind the collected data to be used, subject to legal and ethical constraints, for additional analyses once UDRIVE is finished.During a 21-month data collection effort, UDRIVE will collect information on 210 vehicles, each for one year: 120 passenger cars, 50 trucks, and 40 powered two-wheelers. All data, including video data showing the forward view and the view of the driver as well as GIS data, will be collected continuously to enable knowledge in the various research areas to be brought we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MEchanisms and PHysical processes governing Induced Seismicity: insights from Theoretical models and seismological Observations' (MEPHISTO).

assistant: **Innovation**

Over the last decade induced seismicity became an important topic of discussion both at scientific and societal level. Industrial activities altering the state of stress or the pore pressure of the shallow crust may, in fact, generate seismicity which can be felt by the population, reducing the public acceptance of such activities. The physical connection between operational parameters such as injected (or extracted) volume and the induced seismicity is complex and not yet fully understood. A better understanding of the influence of fluid injection/extraction parameters on the potential failure of pre-existing faults nearby the reservoir is furthermore a fundamental step towards the management of the hazard posed by induced earthquakes. The project MEPHISTO aims to a get insights into the physical processes governing induced seismicity, strengthening the link between seismological observations and geomechanical models. To pursue this scope the project is organized in two complementary work packages (WPs): in the WP1 we plan to develop/improve innovative full-waveform seismological methods for microseimicity characterization, allowing to obtain larger and more reliable seismic catalogues. WP1 aims to retrieve, using innovative full-waveform based methods, a detailed knowledge of the geometry of active faults and stress state within the reservoir. These informations are fundamental for the setup of the geomechanical model. In the WP2 we will use a geomechanical modeling based on fluid flow modeling in poroelastic media and coulomb stress changes to simulate induced seismicity in relation to different geomechanical scenarios. The comparison of the obeserved seismicity with the simulated one will be then used to calibrate geomechanical model and to investigate the influence