RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Performance testing, calibration and implementation of a next generation system-of-systems Risk Governance Framework for nanomaterials' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The objective of the caLIBRAte project is to establish a state-of-the-art versatile Risk Governance framework for assessment and management of human and environmental risks of MN and MN-enabled products. The framework will be a web-based “system-of-systems” linking different models and methods for: 1) screening of apparent and perceived risks and trends in nanotechnology, 2) control banding, qualitative and fully integrated predictive quantitative risk assessment operational at different information levels, 3) safety-by-design and multi-criteria decision support methods, 4) risk surveillance, -management and -guidance documents. The risk management framework will  support assessments of emerging and existing MN and MN-enabled products following the recent ISO31000 risk governance framework, as well as safety in innovation by matching models to the principle innovation steps in the “Cooper Stage-Gate®” product innovation modelControl banding tools and quantitative models will be subject to sensitivity analysis and performance testing followed by a revision as needed. After revision the models will again be analyzed by sensitivity testing, calibration, performance tested to establish the uncertainties. After calibration, the models will be part of the framework, which will be demonstrated by case studies. Stakeholders will be involved for defining the user requirements of the framework and will receive training in the framework at the end. The caLIBRAte project proposal answers to the call of NMP30-2015: Next generation tools for risk governance of MNs. The project is specifically designed to address the key challenges defined in the scope of the call text. There is particular focus on model revision, calibration and demonstration of existing models and methods that suppo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innovative, easily applicable vaccine for poultry industry against five Salmonella serovars: Enteritidis, Typhimurium, Hadar, Virchow  and Infantis – SAL ETHVI' in the context of a Horizon 2020 call.

assistant: **Objectives**

Salmonella species (also called serovars) are important zoonotic pathogens that cause gastrointestinal disease in humans and animals. Poultry products contaminated with these pathogens are one of the major sources of human Salmonella infections worldwide. Salmonella Enteritidis and Typhimurium are the serovars most frequently associated with human food poisoning (78.3 % of all cases in 2003). The serovars of Salmonella having places three to five are Virchow, Infantis and Hadar. Vaccination of chickens, along with other intervention measures in the overall biosecurity system of chicken farms, is an important strategy that is currently being used to reduce the levels of Salmonella in poultry flocks, which will ultimately lead to lower rates of human infections. However, despite numerous studies that have been performed, there is still a need for safer, well-defined Salmonella vaccines. At Immunolab we invented SAL ETHVI – innovative vaccine against above listed 5 serovars of Salmonella. We also breakthrough the technology for the vaccine production in a way that allows any configuration of serotypes, therefore if there is a need for a vaccine against another serovar, its production will be very easy. The end users of the vaccine will be poultry breeders, namely hens and broilers flocks owners. The unique features of our vaccine constituting our competitive adventage comprise : (1) easy application ; (2) low price ; (3) immediate vaccination upon hatching; (4) no risk of bacteria activation and spreading. We have filled a patent application for the technology and upon the vaccine registration and certification, we aim to commercialize it at the broilers markets of the biggest European poultry meat producers: Poland, Germany, France, the Netherlands, United Kingdom and Rus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Establishing defined communities of Antarctic soil bacteria as potential sources of antimicrobials' in the context of a Horizon 2020 call.

assistant: **Objectives**

The discovery of antibiotics is one of the greatest achievements in human medicine. However, the introduction and overuse of antibiotics led towards selection of multidrug-resistant bacterial pathogens that are one of the major concerns of modern medicine. Novel antibiotic classes are the most promising way to overcome current antibiotic resistance. To achieve this goal, antibacterial drug development is re-focused once again on natural products, especially by sourcing not-yet-explored or underexplored environments that represent a rich source of potentially bioactive microorganisms. One of such unique and intact environments is Antarctica with surprisingly high microbial biodiversity. The Antarctic soil microbiome has been proven as a rich reservoir of biosynthetically active bacteria with potential to produce novel antimicrobial molecules. However, simple exploration for antimicrobials among isolated microorganisms has its limitation, one of which is supressed expression of biosynthetic genes in laboratory conditions. The aim of the proposed project is to search for antimicrobial metabolites among unique Antarctic isolates and to streamline the process through a novel approach. Biosynthetic potential of isolates will be firstly characterized through genomics to identify the most promising strains. Afterwards, a novel tool, co-cultivation combined with high advanced omics methods will be implemented to design and grow well-defined microbial communities. Mutual microbial interactions in communities will stimulate metabolic activities of individual strains and expression of otherwise ‘silent’ genes resulting in production of various compounds, some of which may express antimicrobial activities. This project will result in establishment of the first defined Antarctic micr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Exploring electron vortex beams'.

assistant: **Concept**

In this project I will exploit new possibilities opened up by the recent succesful demonstration of our ability to create electron vortex beams in a transmission electron microscope. Electron vortex beams carry a helical phase and angular momentum around their propagation axis. They form the counterpart of optical vortex beams that were invented almost 20 years ago and have lead to many exciting new applications in optics.In preliminary experiments with electron vortices I have demonstrated (Verbeeck et al. Nature, 467,301 (2010)) their usefulness for magnetic state mapping. This property makes them very desirable for solid state physics and materials science since no other tool exists that can map the local magnetisation inside materials with atomic scale resolution. We aim to develop atomic resolution magnetic state mapping and apply it to gain insight in spintronics devices as well as in topological insulators. We will follow two routes to this end, one using the combination of electron vortex beams and electron energy loss spectroscopy (EELS) and another making use of the Aharanov Bohm effect in elastic scattering.Preliminary experiments proof that both routes are feasible and a wealth of interesting physics is ready to be explored.We will also explore the potential of electron vortex beams to manipulate nanoparticles and transfer angular momentum from the electron beam to these particles. This would open up the road to assemble and create nanoscale devices and to study the fundamental laws that govern the interaction between vortex beams and particles with different physical properties.I believe that this highly creative and innovative idea, combined with access to a state of the art transmission electron microscope and a young PI with a proven track record is comb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Identification of various flow regime boundaries in different bubble columns based on Chaos Analysis of CARPT, CT, Optical Probe and Pressure Transducers Data'.

assistant: **Innovation**

The identification of various flow regime boundaries in bubble columns (BCs) is a very important issue because different mass and heat transfers as well as mixing characteristics are observed in each flow regime. In our proposal, the flow regime boundaries will be identified by applying the non-linear chaos theory to Computer Automated Radioactive Particle Tracking (CARPT) and Computed Tomography (CT) data, which will be taken at Washington University in St. Louis (USA) (the outgoing host). Since both CARPT and CT techniques are very sophisticated and expensive, they are not available at any European research centre. Therefore, the accumulation of rich experimental database in the USA and its subsequent treatment by chaotic algorithms at TU Brunswick (Germany) (the reintegration host) will contribute to the enhancement of the EU scientific excellence in the field of BCs. At TU Brunswick (Germany) the chaos theory will be also applied to mass transfer data obtained by means of an optical probe in a high-pres sure (up to 4.0 MPa) BC. In addition, pressure transducers data will be analysed by means of chaos theory.The above-mentioned measurements will be performed in various organic liquids. Numerous gas distributor layouts will be tested, as well. The application of chaos theory to BCs is a new and emerging research area. BCs exhibit a chaotic behaviour and thus chaos analysis can be a powerful tool for flow regime identification. It was shown that the Kolmogorov entropy (KE) profile exhibits a sudden dip at each regime transition velocity. By means of this criterion will be derived empirical correlations for prediction of the various transitional gas velocities in different gas-liquid systems. A model for KE prediction in each flow regime will be developed, as well. By m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Chaotic Cellular Neural/Nonlinear Networks for Solving Constraint Satisfaction' (CHAOPT) targeting Seventh Framework.

assistant: **Abstract**

Constraint satisfaction problems (such as Boolean satisfiability) constitute one of the hardest classes of optimization problems with many applications in technology and industry. In a recent paper the Fellow revealed a novel connection between these problems and chaotic dynamical systems. The paper provided an exact mapping of Boolean satisfiability (k-SAT) into a deterministic continuous-time dynamical system with a unique correspondence between its set of attractors and the k-SAT solutions. It was shown that optimization hardness is fundamentally equivalent to the phenomenon of chaos and turbulence: after a critical constraint density is reached, the trajectories become transiently chaotic before finding the solutions, signaling the appearance of optimization hardness. Numerical results have also shown that the presented dynamical system is very efficient in solving SAT problems. The system presented has the simplest possible form designed for fulfilling the mathematical requirements and is not yet suitable for direct implementation. However, the system is not necessarily unique. Using the same principles the goal of this project is to develop a deterministic continuous-time Cellular Neural/Nonlinear Network (CNN) model for solving constraint satisfaction. CNN models were already implemented in analog computers so this could result in a possible physical implementation of the model in the future, leading to numerous applications. The project will follow three major steps: 1) developing the CNN model and analyzing its mathematical properties. 2) Studying the efficiency of the CNN solver and properties of the transient chaotic behavior in hard problems. 3) Testing the robustness of the model to noise effects.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular dynamics of size sensing at the single cell level.' (SizerSingleCell).

assistant: **Innovation**

Cells have strict control over their size to ensure proper cell physiology. They also have ways to correct for deviations, referred to as cell-size homeostasis, leading to a very narrow distribution in cell size at division. Although some of the genes involved in this process have been identified, the underlying molecular mechanism has remained elusive.  One possibility is that the cell can “sense” its size through a protein whose concentrations are related to cell-size ‒ known as the sizer model.  However, this would not completely explain the fact that diploid cells are approximately twice the size of haploids, suggesting that ploidy also plays a role ‒ something that has not garnered a lot of attention in the field. Live-cell fluorescence microscopy is well-suited to address these issues because we can directly visualize the dynamics and localization patterns of sizers, along with cell-size, and quantify these characteristics. I propose to develop a live single-cell fluorescence microscopy approach using a microfluidics device that allows mother cell lineages to be tracked across multiple generations, for use with haploid and diploid strains of the unicellular eukaryotic organism, Schizosaccharomyces pombe. This will allow me to measure protein levels of sizer candidates and their localization, along with cell length, across single lineages. This information could reveal long-term dynamics and correlations between sizer candidates and cell-size, and provide insight into the molecular mechanisms governing cell-size homeostasis and the role that ploidy plays in governing cell-size control within eukaryotes.


**Keywords:** Cell-cycle, microfluidics, size-sensing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Non linearity and quantum lattice fluctuations in strongly correlated electron systems' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Despite its crucial role in standard superconductivity, the relevance of the electron-phonon coupling in high- Tc compounds is still unclear. More generally, it is not yet understood if in the mild/strong coupling regime the electron-phonon interaction can induce strong correlations between the carriers so as to produce superconducting properties compatible with those of the new superconductors. It is the aim of the present proposal to analyze properties of strongly correlated systems and to investigate theoretically this possibility. In particular, we plan to analyze the transition between the adiabatic strong coupling regime (polaron/bipolaron formation), characterized by the nonlinear properties of the electron-phonon coupling and the antiadiabatic intermediated coupling regime, where quantum effects become relevant. In this regime the bipolaronic ground state is expected to become unstable and form a superconductive condensate state. The transition will be investigated using mathematical and computational techniques previously developed in the analysis of quantum properties of small systems where nonlinearity is dominant.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Automated digital fuel system design and simulation process'.

assistant: **Objectives**

SmartFuel Automated Design and Simulation Process (ADSP) develops a tool-supported automated design and verification process for digital fuel systems. Automating the design process will minimise the cost and time needed while providing a high quality result. Today the design of a digital airborne fuel system is a laborious, iterative process to be repeated each time a new aircraft variant or engine model is employed. It is expected that costly test benches may be made redundant by the new design approach. This will provide a significant competitive advantage to the user of the system. In order to test the designed system a simulation system will be defined and developed for the verification of compliance of designed system functionality against the basic system requirements. Simulation of flight operation procedures will be done allowing testing and analysing the functionality of the newly developed system before any hardware is built.SmartFuel ADSP relies and utilises results of the EU funded project SmartFuel (FP5, started Oct. 2002). It is anticipated that the automated designed system will produce the following benefits:- 60% reduction in the time for developing of a fuel system- 70% reduction in the cost for developing of a fuel system- 50% reduction in the time to market for future complete fuel systems- 25% in improvement in the reliability of those systems developed using ADSP- 50% reduction of the cost of new system due to a better use of COTS components- 40% in the reduction of maintenance cost due to advanced quality of the designThe SmartFuel ADSP is coordinated by Autoflug, which is a small and medium sized enterprise. Autoflug and most of the other partners in SmartFuel ADSP are members of the (virtual) fuel system consortium. Availability of the Digital F
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Targeted Anti-Cancer Therapies', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Antibody-Drug Conjugates (ADCs) are fast growing classes of oncology therapeutics. They consist in a highly potentcytotoxic drug connected via a linker to an antibody that is specifically targeting certain tumor markers. By combining thecytotoxicity of the drug and the targeting properties of the antibody, ADCs kill cancer cells whilst leaving the healthy cellsunaffected, a marked improvement compared to classical chemotherapies. However, limitations still exist which could fuelthe development of new generations of ADCs with improved therapeutical properties. Targeted Anti-Cancer Therapies(TACT) is an innovative, international, multidisciplinary training and research programme which thus aims to train 11 Early-Stage Researchers (ESRs) on the development of state-of-the-art anti-cancer therapeutics and equip them with transferable,future career-enhancing skills to create the next generation of experts in Europe. More specifically, TACT’s researchprogramme will focus on key priorities for the conception of new and more potent generations of Protein-Drug Conjugates(PDCs): site-specific bioconjugation methods, more potent payloads, environment-specific cleavable linkers, more efficientprotein-based targeting systems and new analytical tools for acute characterization. This will be achieved by exposing theESRs to the leading intersectoral research scientists and laboratories in Europe who are active in this field. In doing so,TACT combines state-of-the-art research with excellent training in PDCs, one of the hot topics in cancer and targetedtherapies.


**Keywords:** Bioconjugation,  ADC,  PDC,  Antibodies,  Immunotherapy