RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Strategic Narrative of Nuclear Order' (SNNO) under Horizon 2020.

assistant: **Objectives**

In this project, I investigate the emergence, projection, and contestation of what I call the 'strategic narrative' of nuclear order in Europe. This narrative emerged in the 1960s as the ideological foundation of the nuclear non-proliferation regime, displacing alternative visions of nuclear politics such as comprehensive disarmament and a supranational European nuclear community. Navigating between the alleged extremes of immediate abolition and unrestrained proliferation, policy elites in Europe and North America converged on the goal of freezing nuclear politics in its current form. For the narrators of nuclear order – influential policymakers and defence intellectuals – the primary task of any diplomatic process should be to avert disruptive changes and secure stability through managerial control. To that end, the narrators of nuclear order promoted the ideas that nuclear weapons are indispensable for the maintenance of peace, that extended nuclear deterrence provides a bulwark against proliferation, and that nuclear risks are controllable. This narrative has since been solidified through official government communication and incorporation into high-school textbooks, policy discourse, print and broadcast media, and other cultural products. The strategic narrative of nuclear order has been most powerfully projected by members and supporters of NATO. The continuation of the policies of extended nuclear deterrence, ‘nuclear sharing’, and step-by-step arms control has come to be defined as irreplaceable elements of the alliance’s material and ontological security. Since the end of the Cold War, however, the narrative of nuclear order has collided with attempts at developing an image of Europe as a human-security oriented normative power. Moreover, the prevailing narrati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of strategies to eliminate cancer cells from the bone marrow' (ELIMINATE).

assistant: **Concept**

The bone marrow (BM) represents the prime location in which cancer cells survive aggressive treatments. This poses a major health challenge because the mortality rate of patients with curable cancer doubles if tumor cells persist in the BM. One unresolved question is why the immune system fails to eradicate cancer cells from this microenvironment even though it represents a lymphatic organ. Surprisingly, despite the ongoing revolution in immune oncology, the regulation and potential therapeutic activation of the immune response in the BM still remains largely unexplored. In this grant application a new line of research is proposed with the overall objective of understanding the cellular and molecular mechanisms, which control anti-cancer immune responses in the BM. The originality of this proposal relates to the hypothesis that innate and adaptive immune cells are suppressed by stroma cells in the BM. Therefore, we will conduct a comprehensive phenotypic and functional profiling of immune and stroma cells in the BM of cancer patients with and without persisting tumor cells. Based on these insights we will develop novel strategies to harness the immune system to eliminate malignant cells from the BM. The ground-breaking nature of the project is that it will shed light on the unappreciated immune microenvironment in the BM. Its specific strength lies in the multidisciplinary design encompassing informative patient cohorts, state-of-the-art mouse models and cutting-edge technologies including Next-Generation-Sequencing as well as innovative drug candidates. Hereby I can build on my internationally recognized expertise in the BM microenvironment field, which has already led to the successful development of a clinical-stage drug. Novel strategies to eliminate malignant cells
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Tracking conformational dynamics of cohesin with MINFLUX' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The DNA contained in each of our cells has a size of about 2 m and is fitted into the nucleus which is about six orders of magnitude smaller. It is unclear, how this extraordinary compaction is achieved and how the cell can still carry out highly regulated processes like gene expression, DNA replication, and DNA repair in such a dense environment.Cohesin is a protein that has been shown to play an important part in DNA compaction, especially in sister-chromatid cohesion. Recently, it has been observed that cohesin extrudes loops of DNA to achieve compaction, but how exactly it carries out its function is unknown.Fluorescence spectroscopy is a powerful tool to investigate conformational dynamics of biomolecules. MINFLUX is a recently developed method which localizes single molecules with a precision of a few nanometers. Here, I propose a new method based on MINFLUX which will allow to track fluorescent labels on large bio-molecular complexes with nanometer spatial and millisecond time resolution. The method will be used to study conformational dynamics of cohesin in vitro and investigate the mechanism of loop extrusion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Collaboration Environment for strategic innovation' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Innovation has become the main source of competitive advantage for European companies in the globalised economy. Existing collaborative working environments (CWEs) mainly focus on supporting traditional working paradigms of linear workflows by providing IT-based platforms for planning, scheduling and executing tasks. However, in order to achieve continuous strategic innovation and thus create persistent competitive advantage, organisations need to increase their capacity for carrying out open-ended and nonlinear problem solving involving a wide participation of people in knowledge-rich environments. This must be supported by the next generation CWE's, which in turn, requires new paradigms for managing the knowledge transfer, the social dynamics, and the decision processes involved in the front-end of innovation.The goal of Laboranova is to create this next generation Collaborative Tools which will change existing technological and social infrastructures for collaborating and support knowledge workers and eProfessionals in sharing, improving and evaluating ideas systematically across teams, companies and networks. Laboranova will do research to develop and integrate models and tools in three specific areas, the three pillars in the project: ideation, connection and evaluation and decision making. These pillars will be leveraged by advanced game methodologies in order to improve collaborative work processes.By integrating these efforts the results will be innovative collaboration approaches and organisational models for managing early innovation processes, software prototypes and the integration of the isolated models and tools into a Collaborative Innovation Platform. This will change the way knowledge work is done and increase the innovative output of companies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The 9th International Conference on Intelligent Systems for Molecular Biology - 2001' (1998-2002).

assistant: **Innovation**

The ISMB2001 conference provides a general forum for dissemi- nating the latest developments in bioinformatics. It is the 9th conference in a truly multidisciplinary conference series that brings together scientists from computer science, molecular biology, mathematics and statistics. Its scope includes the deve- lopment and application of advanced computational methods for biological problems. Relevant computational techniques include, but are not limited to: Machine learning, pattern recognition, knowledge representation, databases, combinatorics, stochastic modelling, string and graph algorithms, linguistic methods, robotics, constraint satisfaction, and parallel computation. Biological areas of interest include biomolecular structure, genomics, biomolecular sequence analysis, evolution and phylogene- tics, biomolecular interactions, metabolic pathways, regulatory networks, developmental control, and molecular biology generally. Emphasis is placed on the validation of methods using real data sets, on practical applications in the biological sciences, and on development of novel computational techniques.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00364-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Perception of contact chemicals by parasitic wasps' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content The project will study the chemoreception of (apolar) arrestants (host related cues) and feeding stimulatory chemicals by | parasitic wasps (parasitoids) and the variation in the response to those compounds at the periphera/sensory level due to learning/experience.The project is expected to yield the first information on taste perception by parasitoids and on the chemoreception of apolar | compounds by insects in general. Two closely related wasps, Cotesia glomerata and C. rubecula (Hymenoptera: Braconidae), will be used as model organisms Their host location behaviour is well understood and they differ strongly in their host and host-stage specifity and in their | ability for associative learning. Results of this project will help to understand the link between sensory physiology and behaviour, and the relationship | between associative learning and changes in the electrophysiological response of chemoreceptors in the two Cotesia species. Training content (objective, benefit and expected impact) The applicant will be given the opportunity to learn new methodologies involved in measuring the electrophysiological response of parasitoids to contact chemicals. This is a new field of research which is of great interest as it allows us to understand the physiological processes behind the behaviour of parasitoids which has been studied in great detail. In addition, the project will link two research groups at the host institution which so far had little collaboration. Links with industry / industrial relevance (22) The project does not have active involvement with the industry. However, there are links between both host research groups with European industries in the field of semiochemistry and suppliers of biological control agents (see detail
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Theoretical implications of microlensing searches', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content  My main research objective is seeking to identify the nature of the dark galactic halos, with particular emphasis on baryonic candidates. The interpretation of the AGAPE microlensing results towards M31 will give new key-elements. I also plan to investigate others alternatives for baryonic dark matter. In parallel I will take part to forthcoming AGAPE observations towards M31. (55%)  Surface brightness fluctuations on ellipticals or bulges could be measured on existing data (AGAPE, HST). A distance estimate could be deduced using stellar population models and contribute to the Ho deter- mination. (20%)  During my thesis work I have discovered a large number of very red stars. The identification of these stars could allow to extract possible new informations on stellar physics. (25%)  Training content (objective, benefit and expected impact)  The objective of this training is to study direct and indirect theoretical implications of microlensing surveys, using my expertise on observational aspects and my access to the data. The main benefit is to enlarge my field of research, engage international collaborations and keep contact with french people. With the approach outlined in the research programme, we should be able to identify the nature of the halo dark matter. In parallel new results are also expected from the variable stars and SBF projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Seizing Electron Energies and Dynamics: a seed for the future'.

assistant: **Concept**

Electronic correlation causes a wide range of interesting phenomena,  such as superconductivity or the fractional quantum hall effect. It strongly impacts our surroundings – think about defect creation through a self-trapped exciton, or, in the animal world, the adhesion of a gecko on a surface (through the van der Waals attraction). Although the underlying Coulomb interaction  is « simple » and well understood, a unifying framework is still missing that would allow us to describe, analyze, understand and predict all those phenomena on the same footing. In this project we will introduce and establish a completely new method for the calculation of properties of correlated electron systems including ground state total energies, excitation spectra, electron-phonon coupling and non-equilibrium dynamics. The method is based on a non-perturbative solution of a multidimensional functional differential equation. This equation is the SEED from which distinct sub-lines of research will be grown.Based on my widely recognized experience in the field of many-body physics and starting from recent results of an exploratory study, the project will encircle the problem working on different levels of approximation, each of them introducing new physics. Thus every step along the project will allow us to tackle challenging questions, such as: “Does strong coupling in a material lead to new or exotic elementary excitations?” or “What can we say about multi - exciton generation, and how could it be tuned?”. These questions and our theoretical answers will be embedded in a tangible context through the study of emerging topics including Mott insulators and materials for photovoltaic applications. Each of these theoretical steps and planned applications carries the potential for breakthrough; t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MicroLED Pixel Display for Augmented Reality Smart glasses' (MICROPIX).

assistant: **Innovation**

The nascent global augmented reality market is expected to exceed $60 billion in 2023, and offers a lot of growth opportunitites. We expect Augmented Reality to become a part of everyday life as AR smart glasses will make people more connected than ever, in real time, with hands-free and heads-up toward the world. They will also be used to increase productivity for companies in most industries. The race to produce the first pair of commercially successful augmented reality glasses is on, but all products present major drawbacks such as low brightness, low resolution, big size, small field of view, reduced eye box resulting in limited experience. All major drawbacks are linked to microdisplays' weaknesses. Many miniaturised components from the smartphone industry can be integrated into smart glasses but the display is the bottleneck and the main challenge for manufacturers. Current commercialized microdisplays will never meet requirements to produce cutting-edge smart glasses. A new generation of microdisplay has to emerge. MicroLED technology, the same LED technology which revolutionized general lighting 10 years ago but scaled down to microscale pixels, is the most promising solution and must be developed. MicroLED displays have the potential to change everything as they can offer unparalleled higher brightness, a  better reliability be more compact, offer lower latency, provide better contrast ratio and be energy efficient compared to current display technologies. This is exactly what the AR smart glasses market needs. Our latest breakthrough innovation will bring the solution by allowing the fabrication of full color RGB matrices for high-end microdisplays, completely adapted to cutting-edge augmented & mixed reality smart glasses. It is a great opportunity and a goo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project '4D Printing of Human Vascularized Cardiac Patches and Hearts for Regenerative Medicine' (4DPrintedHeart), addressing dissemination and exploitation.

assistant: **Impact**

Heart diseases are a major cause of death in the Western world. No sustainable regenerative therapy is currently available, and cardiac transplantation is the only treatment. However, the scarcity of matching heart donors raises the need to develop new regenerative medicine approaches. Recently, our group has shown the use of patient-specific cells and personalized hydrogels to 3D print vascularized cardiac patches. Moreover, we have developed printing technologies which allowed to print small-scale, cellularized human hearts with the major blood vessels. Despite these and other advances in the field, the premature hearts are very basic, and their ability to pump blood and function in vivo is still considered futuristic, requiring several major breakthroughs. In this proposal, I plan to go far beyond the current state-of-the-art and overcome some of the remaining challenges in the field. We will develop novel 4D printing approaches, allowing to print human cardiac patches and whole functional hearts, including ventricles, atria, pacemakers, conduction system and extensive vasculature, in high resolution. We will decipher the mechanisms underlying the maturation of the printed tissues and hearts, which are essential for the synchronous contraction and heart pumping. Functionality of the printed structures will be compared to that of native cardiac tissues and whole natural hearts by examining their reaction to chronotropic and cardiotoxic drugs, proving their additional potential to serve as reliable, predictive drug testing platforms. The printed tissues and hearts will be then heterotopically transplanted, and their anastomosis with the host blood vessels, contraction and blood pumping capabilities in vivo will be tested. Finally, we will demonstrate the ability of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Authentication and Authorisation for Research and Collaboration (AARC)' (AARC).

assistant: **Innovation**

The goal of AARC is to address technical and functional gaps that prevent the interoperability of existing R&E AAIs. AARC objectives are:1. Deliver the design of an integrated cross-discipline AAI framework, built on federated access production services (eduGAIN) 2. Increase the uptake of federated access within different research communities3. Pilot critical components of the proposed integrated AAI where existing production services do not address user needs4. Validate the results of both the JRA and SA by engaging with the research communitiesAARC goals will be achieved by:• Researching main technical (attribute providers, guest IdPs, support for non-web SSO) and policy aspects (level of assurance, security incidents, etc)• Supporting (commercial) services relevant to the R&E community• Delivering training to targeted user communities (e.g. libraries, biomedical, arts and humanities) on both technical and legal aspectsRelevance to the work programme: 1. Facilitate the deployment and promotion of a pan-European identity federation – Met by:• Designing an AAI framework that builds on federated access and on the evolution of eduGAIN’s interfederation approach  • Extensive dissemination of AARC results 2. Lower barriers to entry for organisations – Met by:• Delivering tools to enable federated access for institutions, services and guest users (also meets obj. Allow for public access at large) • Delivering technical training tailored to institutions and services following the train-the-trainer model (also meets obj. Offer training and outreach for data professionals)3. Overcome technical, organisational and legal obstacles – Met by:• Policies and best practices for operational and security aspects for the integrated AAI• Training on legal aspects, built on experience with