RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Understanding nitrogen signalling and metabolism to tailor plants with improved sink-source relations and nitrogen utilization characteristics', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

We aim to investigate and manipulate nitrate metabolism and signalling in order to produce plants with improved nitrate use and sink-source relations. Nitrate and nitrogen metabolites act as signals to regulate metabolism and resource allocation affecting many key processes such as the uptake, assimilation, and accumulation of nitrate, the regulation of the cytosolic pH, the regulation of organic acid and starch metabolism and the regulation of source-sink interactions including shoot-root allocation, the timing of flowering, and nitrogen re-mobilization during seed filling. To achieve this objective, we will: (a) produce and analyse Arabidopsis transformants with altered expression of nitrate transporters, and of native and modified forms of nitrate reductase. b) analyse the signalling pathways that regulate the expression, activity and turnover of these proteins. We will isolate Arabidopsis mutants defective in nitrate-induction or ammonium-repression of these genes, and identify and investigate the biological function of nitrate-induced genes whose sequence indicates a role in signal transduction. We will also analyse the post-translational regulation of nitrate reductase. This is a biochemically amenable system, in which rapid progress is being made in the identification of key structural features of the target protein, and components of the transductlon pathways including multiple protein kinases and 14-3-3 proteins. Molecular Characterization of these signalling pathways will provide us with tools and Strategies to overcome endogenous feedback regulation and maximise the Expression of the genes and activity of the proteins needed for nitrate acquisition. It will also allow us to identify other important target proteins that are regulated by these signalling pathwa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Open collaboration and open Digital Twin infrastructure for Green Smart Shipping' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

DT4GS is aimed at delivering an “Open Digital Twin Framework” for both shipping companies and the broader waterborne industry actors to tap into new opportunities made available through the use of Digital Twins(DTs). The project will enable shipping stakeholders to embrace the full spectrum of DT innovations to support smart green shipping in the upgrade of existing ships and new vessels. DT4GS will cover the full ship lifecycle by embracing federation of DT applications as well as utilising DTLF policies and related shared-dataspace developments for the sector. DT4GS applications will focus on shipping companies but will also provide decarbonisation decision-support system for shipyards, equipment manufacturers, port authorities and operators, river commissions, classification societies, energy companies and transport/corridor infrastructure companies. DT4GS’s objectives are to: 1. Support shipping companies in achieving up to 20% reduction in CO2e with a 2026 horizon, by developing and deploying real-time configurable DTs for ship and fleet operational performance optimisation in 4 Living Labs involving shipping companies, with different vessel types, and establishing fully validated industry services for Green Shipping Operational Optimisation DTs expected to be adopted by 1000+ ships by 2030.2. Establish a comprehensive zero-emission shipping methodology and support Virtual Testbed and Decision Support Systems that address both new builds and retrofits comprising: a. A DT4GS (Green Shipping) Dataspace for the broader shipping sector contributing to GAIA-X by establishing a core European industry resource that accelerates the green and digital transition of waterborne shipping and transport value chains.b. Simulation based solutions to retrofit ships, targeting 55% r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Renewable systems engineering for waste valorisation ΙΙ'.

assistant: **Innovation**

The project  goal is  to further advance the emerging area of Bio - process - systems engineering (BPSE) by capitalizing the recent advances and ITN of RENESENG (FP7 - PEOPLE - ITN) toward the following  project objectives :- Expanding the knowledge for value chains across feedstocks,  products and industries, e.g., by  looking into the potential of MSW (including food waste) energy chemicals nexus.- Investigating the area of  knowledge management (i.e., data structures, workflows, protocols)  for the effective communication across the diverse academic research scales and industrial applications (i.e., lab to unit operations, toprocess and plant design, to business development, sustainability assessment).- Applying the existing RENESENG tools, models, methods, know how as well as the newly  developed in this project to emerging topics of bioeconomy and links to circular economy,  with special focus on various forms of “waste” biomass (e.g., MSW, glycerol, lignin). Enhancing the network with new aca demic and non academic partners and significantly  contributing via meaningful secondments to the career development of ESR and ER.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Smartphone-based Mobile Positioning System' (SmartPosition).

assistant: **Innovation**

This project aims to develop two new estimation paradigms for designing a reliable, high precision and real-time mobile positioning system (MPS): clustering for filtering (C4F) and fitting for smoothing (F4S). The present MPS faces two immediate challenges from the real life world. First, little is known about the background and therefore accurate system modelling is difficult or even impossible and the use of conventional filters/smoothers is challenging or even infeasible. Secondly, the data is very rich in the sense that it comes from multiple and many types of sensors with improved scanning frequency and accuracy. The rich sensor data can be used to circumvent poor background knowledge and to provide a greater breadth of observation regardless of individual sensor failure. However, it is expected that rich data will also pose a great challenge for real time filtering implementation.This project will develop a new concept, “Big Sensor”, to flexibly utilize the rich time-varying sensor data in the concerned MPS and to implement C4F and F4S. The Big Sensor-based C4F and F4S use all available information including WIFI, Bluetooth, GPS signals as well as altitude, acceleration, and direction information based on embedded software to locate mobile devices. The resulting MPS will not rely on sophisticated filters and will therefore be more reliable and computationally faster.The research emphasis of the project will be on flexible and optimal sensor data inference which is found by developing novel clustering and fitting algorithms. The researcher and the partitioning organizations have synergic expertise and solid research track records in the related fields. Smartphone-based realistic MPS applications (apps) will be developed, with the potential use of European GNSS. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of NG2 cells in the neural network in health and disease' (NG2-cells) targeting Horizon 2020.

assistant: **Abstract**

Loss of myelin and oligodendrocyte dysfunction is being recognized in many neurodegenerative diseases, such as Multiple Sclerosis, Alzheimer's or Parkinson's disease or Epilepsy, although the mechanisms are not yet understood. Oligodendrocytes are generated from NG2 cells, a glial cell population that covers the entire parenchyma of the central nervous system. The multitude of disorders involving oligodendrocyte pathologies in grey and white matter underscores the importance to understand how oligodendrocyte differentiation and myelination are regulated, and the role of NG2 cells therein. The highest density of NG2 cells can be found during the first postnatal weeks, when they differentiate into mature oligodendrocytes ensheathing axons with myelin. NG2  cells retain the capacity for self-renewal throughout life, rendering them a huge regenerative potential in the adult brain. It is still unknown whether all NG2 cells have the same potential to generate oligodendrocytes or whether a subpopulation of them becomes permanent NG2 cells. Neurons form synaptic contacts onto NG2 cells and depolarize them, in order to regulate myelination. Considering the finding, that processes of NG2 glia contact neurons at the node of Ranvier, it could be possible that NG2 cells in turn are able to modulate neuronal activity. To address these questions, this project is designed to investigate how altered neuronal excitability affects the structural and functional relationship between neurons and NG2 cells and how these changes impact the neural network. Using a combination of several cutting-edge techniques, the details of the morphological contact formation as well as the physiological function of these contacts in vivo in models of enhanced neuronal activity will be assessed. The results w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Towards a computational account of natural sequential behavior' under Horizon Europe.

assistant: **Concept**

Imagine navigating through your kitchen, walking around your table and chairs, reaching the counter, sliding a cup on the countertop, pouring yourself some coffee, and preparing a sandwich. Such an every-day situation requires a sequence of behaviors involving the sophisticated interplay of perception, attention, cognition, planning, and action, all unfolding in an ambiguous and uncertain world. Yet, although past research in the behavioral sciences has revealed many properties of these constituent faculties, the understanding of how humans coordinate these cognitive abilities when carrying out every-day tasks is still rudimentary.The goal of this project is to carry out behavioral experiments and develop computational models to identify and characterize perception, cognition, and action in the wild. Our hypothesis is, that sequential actions involving perceptual uncertainty, action variability, internal and external costs and benefits can be understood and modeled in the unified framework of optimal sequential decision making under uncertainty. To achieve this goal, we integrate ideas and methods from psychophysics, statistical decision theory, active vision, intuitive physics, optimal control under uncertainty, navigation, and inverse reinforcement learning. The proposal is structured in such a way that subsequent work packages consider tasks with increasing naturalness, from classical psychophysical production tasks, visuomtor control, to navigation and sandwich making. We will develop methods that allow recovering subjects’ perceptual uncertainties, beliefs about tasks, their subjective costs and benefits including effort, and action variability. Based on our previous experimental work on visuomotor behavior and theoretical work in modeling such behavior on an indiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A novel immunotherapy against brain metastasis: Anti-Galectin-3'.

assistant: **Innovation**

The development of new cancer treatments has significantly improved life expectancy of patients. However, these advances increase the risk of suffering from secondary tumours (metastases). Particularly, breast cancer brain metastases are a major cause of morbidity, with meagre life expectancy (3-18 months). These facts highlight the urgent need to find better treatment against this disease.Immunotherapy has recently gained great momentum in the clinic to treat different type of cancers. However, its therapeutic use for metastatic spread to the central nervous system (CNS) remains scarce. The immune response within the CNS during metastasis progression greatly depends on microglial cells (resident CNS macrophages). Their roles in neuroinflammatory and neurodegenerative processes have been intensely investigated, whereas their function in metastasis has received minor attention. During brain metastasis, microglia show impaired immune defence, secreting a variety of anti-inflammatory cytokines (e.g. IL-10 and TGF-B) and growth factors which may contribute to metastasis progression.A key molecule which might alter such adverse behaviour is beta-galactoside-specific animal lectin galectin-3 (Gal-3). Studies of this promiscuous protein has shown a pivotal role during tumour progression and metastasis to non-CNS sites. Importantly, recent studies from Prof Venero’s group have shown how inhibition of microglial Gal-3 shifted the phenotype of these cells into a more pro-inflammatory state. Therefore, since pro-inflammatory state in microglial cells has been described  to exert anti-metastatic effects, Gal-3 inhibition may provide a powerful  and novel brain metastasis immunotherapeutic approach. Moreover, the fact of the existence of Gal-3 drugs in current clinical trials enhanc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Preparatory steps towards a GMO research ERA-Net' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The objective of the PreSto GMO ERA-Net project is to clearly map out the steps needed to create and successfully implement an ERA-Net that will coordinate transnational research on the effects of genetically modified organisms (GMOs) in the areas of human and animal health, the environment, and techno- economics and societies. The focus of the ERA-Net will be on GMOs intentionally released into the environment and/or used immediately in feed and food applications. PreSto GMO ERA-Net brings together ministries, agencies, and funding bodies from different Members States and the scientific community to jointly prepare a strategic plan and roadmap for the implementation of the ERA-Net. In addition, the ERA-Net will explicitly take into account the wider views of a diversity of stakeholders and end-users (e.g. non-governmental organisations, industry, farmers). This is intended to strengthen ownership of the ERA-Net among stakeholders in order to encourage participation of different scientific communities in the future joint transnational calls, to enhance collaboration between actors and to increase the accountability of research trajectories and outcomes.The results of the project will form the basis for a robust ERA-Net proposal. In achieving this the project work will (1) promote the accessibility of existing scientific information to interested stakeholders and end-users, (2) lead to the harmonisation of research requirements and capacity building within Europe, (3) complement international developments, (4) contribute to a more efficient use of research funds internationally and (5) identify how strategic collaboration can be used to respond to these future research and training needs through enhancement of durable partnerships.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dissection of Glycan Function by Engineered Tissue Models' to be submitted under Horizon 2020.

assistant: **Abstract**

Glycans decorate most proteins, cover cell membranes, and represent one of the four building blocks of life, together with nucleic acids, lipids, and amino acids. Yet, our understanding of how glycans influence the life of cells and organisms is limited, and only few functions have been molecularly dissected. Glycans present a huge structural diversity with species and cell- type specificity that underlie specific biological functions. However, more than half a century of research has been severely hampered by the complexity and technical difficulties with analyzing glycans. While, the glycome (all glycans in a cell or organism) is a difficult entry point for discovery, the glycogenome (all genes involved in glycosylation) in contrast is a feasible entry point, because most of the genes controlling glycosylation are now known, and there are fewer technical barriers especially with the emergence of gene editing technologies.Our research group has pioneered the “glycogenome entry” to functional glycomics using gene editing to simplify glycosylation in cells. My research group has pioneered a next generation approach using organotypic tissue models in combination with sophisticated mass spectrometry to decipher glycan functions. The tissue model has provided the first evidence that aberrant glycosylation in cancer directly induce oncogenic features, and that glycosylation of Herpes virus is essential for viral propagation. In this proposal, I will use step-by-step genetic deconstruction of glycosylation capacities in organotypic tissue models for broad discovery and dissection of specific structure-function relationships driving normal epithelial formation, transformation and interaction with the microbiome. Specifically, I will address:1. How glycosylation affect and shap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ascmap' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Marine phytoplankton are the major, sustaining components of ecosystem processes and are responsible for biogeochemical reactions that drive our climate changes. Despite this, many phytoplanktoners are poorly described with little known of broad spatial and temporal scale trends in their abundance and distribution. With new molecular and analytical techniques we can advance our knowledge of phytoplankton biodiversity at the species level to understand how phytoplankton biodiversity supports ecosystem structure, dynamics and resilience. We can then interpret environmental, ecological and evolutionary processes controlling and structuring marine phytoplankton biodiversity. Objectives of the proposed conference are:1) To provide training in the state of the art developments in flow cytometric analysis of phytoplankton populations, 2) To introduce the development of artificial neural networks to analyse the complex multivariate nature of flow cytometric data to provide an automatic identification system for marine phytoplankton, 3) To demonstrate the use of hierarchical ribosomal rRNA probes to identify and quantify phytoplankton biodiversity.With these methods to hand, we can augment our understanding of biodiversity and ecosystem dynamics in especially the pico- and nano fractions of the plankton that have few morphological markers for identification and from which, 3 new algal classes have been documented in the last 10 years. Within 2 EU projects, EU AIMS and EU PICODIV, workshops were planned as a means of disseminating the information to the scientific community.This EU conference is planned to fulfil this obligation. The goals of the EU AIMS Project are to provide an automated identification system for the identification of marine phytoplankton using flow cytometric