RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Energy Harvesting for Precision Agriculture Applications'.

assistant: **Innovation**

ENTRAP is multidisciplinary research project aimed at developing an Energy Harvesting (EH) device which will convert the locomotion of domestic animals, i.e. animal kinetic energy, into electrical power. This device would then supply autonomous power to a wide range of wireless sensing Precision Agriculture applications. Precision Livestock Farming is used to monitor individual animals' health, behavior, location and more so as to increase the efficiency and sustainability of food production. Millions of battery powered smart collar devices used in Precision Livestock Farming are being marketed today in the EU and through ENTRAP these devices will become powered by the animals themselves. In fact, the locomotion of domestic animals hasn't been characterized as a power source at all and to develop an EH device designed specifically for free grazing animals, extensive field experiments are necessary. Experiments are designed in cooperation with the Faculties of Agriculture in Zagreb and Helsinki, and will be performed at their respective experimental farms. The host beneficiary, Tampere University of Technology, is providing  supervision in electromagnetic EH device design through mentorship by asst. prof. Paavo Rasilo, an expert in modeling of electromechanical systems. To enhance the projects prospects of success and to gain knowledge necessary for the development of my future career I will be seconded to an industry leader in the EH field, ReVibe Energy(SWE). The device will be integrated at Nofence(NOR), the world's first producer of a cloud based Virtual Fencing system (a Precision Livestock Farming application). The motivation for  the restart of my career arose from an academic break and subsequent 6 months spent as a goat herder which allowed for this novel resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multianalyte automatic system for the detection of drug resistant bacteria' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Infectious disease are responsible of high human health burden and cost. Time to diagnosis release and quality of the microrganism detection represent an area of interest for optical fiber based device application.OPTObacteria propose an highly expert consortium in which 4 SME and 4 research peformers from 3 European countries would synergize their efforts to provide a unique Automatic Laboratory Detector (ALD) to deliver a drug resistance report in a 4 or 4-8 hours timeframe. The time is depending on the experiment required, it avoid bacterial grwoth time, typical of the antibiogram typical report and provide an detection up to low ng concentration or even low. With respect to other optical-based device (like SPR, surface plamon resosnance) many limitations are overcome.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Engineering B cells to fight cancer' (EngineerBcells) under Horizon Europe.

assistant: **Objectives**

B cells have an important role in the immune response against cancer. Tumor specific B cells in tertiary lymphoid structures and anti-tumor antibodies in the plasma are associated with a favorable prognosis and with an improved response to checkpoint inhibition in different sarcomas and carcinomas. Antigen specific B cells home to tumors and prolong survival in mice, while B cell based vaccines allow durable anti-tumor activity in cervical cancer patients. We have recently demonstrated both ex vivo and in vivo B cell engineering for the expression of anti-HIV antibodies. Here, we propose a novel cancer immunotherapy approach based on engineered B cells. In particular, we use CRISPR/Cas9 and AAV to target the integration of anti-tumor antibody genes into the IgH locus. In diverse tumor models, we plan to demonstrate localized B cell activation upon antigen engagement. The B cells will exert multiple anti-tumor effects. Secreted antibodies will induce ADCC, CDC and ADCP. In addition, a polyclonal T cell response with epitope spreading will be facilitated by engineered B cells acting as APCs as well as by antibodies forming immune complexes to be taken up by dendritic cells and macrophages for cross-presentation. The B cell will be co-engineered to locally secrete additional immune effectors upon activation. These include: stimulatory cytokines, BiTEs, checkpoint inhibitors, CD40/27 agonists and cell penetrating nanobodies. Localized secretion is predicted to increase efficacy while reducing systemic toxicities. When targeting self-antigens, B cells will be engineered to co-express a CAR, relaying CD40 or TLR signals for T cell independent B cell activation and allowing allogeneic therapy. We will further demonstrate in vivo B cell engineering for increased scalability, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mechanisms of Soil Restructuring by Bacterial Aggregates: towards a more efficient and resilient Agriculture' (AgriGate).

assistant: **Innovation**

Soil bacteria are of critical importance to soil health. Soil pore-size distribution over multiple length scales, which facilitates nutrient transport, depends on the presence of soil aggregates, cohesive organo-mineral assemblies formed by bacterial activity. Aggregates support plant health and increase soil stability. Although restoring aggregate structure in degraded soil can yield great benefits for extreme-weather resilience and agricultural productivity, we lack any mechanistic understanding of how aggregates are formed by bacteria. This knowledge gap hampers the deployment of promising bio-augmentation strategies for soil restoration, such as inoculation of soil with aggregate-promoting bacteria. The objective of AgriGate is to narrow this gap by elucidating the biophysical mechanisms of bacterial aggregate-formation. I will focus on the reciprocal mechanical interactions between bacteria and soil grains, using interdisciplinary methods over multiple spatial scales. I will first develop a novel microfluidic chip granting real-time optical access to bacterial dynamics inside a three-dimensional bed of model soil grains. AgriGate’s hypotheses are that (1) there exists an optimal grain size and inoculant richness for bacteria-led aggregation, and (2) that bacterial extracellular polymeric substances (EPS) are necessary for aggregation. I will test these hypotheses by varying grain size, inoculant richness, and bacterial EPS-production in the chip. Microfluidic experiments will be combined with experiments in bacteria-loaded soil columns observed by X-ray tomography, to extend results to the macroscopic scale and link microscale structure to macroscale function. The search for optimal aggregation conditions will be formalized mechanistically and extended by a numeric
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LELY SIC HIGH TEMPERATURE POWER DIODE FABRICATION' (PODILESCA).

assistant: **Concept**

Though the worldwide state of knowledge in SiC technology is already well advanced (as demonstrated by prototypes holding records at high temperature, high voltage and high microwave power), the SiC devices market is behind due to basic material problems. Actually, the Lely modified" SiC substrates, which are more suitable for large scale wafer production, suffer from a high density of structural defects and they are not yet acceptable for large active area components. On the other side, the very pure "Lely" SiC substrates are no longer fabricated, and only 1 cm2-area substrates are available today from a remaining stock that belongs to the Russian Company "Compozit" Ltd. However, the main investigator in SiC growth technique by the "Lely" method is still the manager of "Compozit".Having gathered three important partners in this field - a good quality SiC supplier ("Compozit" Ltd., RU), a technology provider for High Temperature Power Diodes (LSPD laboratory, RU), and a semiconductor industry interested in SiC components manufacturing (BANEASA, RO) -, the aim of this project is to demonstrate the feasibility of a Lely SiC high temperature (300°C) power (400 V, 5A) diode fabrication in industrial environments. The main role of the French, Romanian and Spanish research teams also involved in the project is to bring their skills in designing, modelling and characterising SiC devices and material. The birth of an innovative high temperature power diodes commercialisation in Romania, and the renewal of a "Lely" SiC material industrial production in Russia (with an enhanced substrate size) are the two main objectives of this project."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Substitution of o-phthalate plasticizers used in rotomoulding' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Di-alkyl-phthalates are the compounds mainly used as plasticizers in the manufacture of vinyl plastisols These plasticizers have subject of recent controversy due to their potential toxicity. Some limitations to their use in toys for babies are likely to be implemented in a short term for the migration of such components. This new situation will require the substitution of these materials in toys manufacturing. The use of di-alkyl-phthalates has not represented any obstacle up to now , since they were used to fulfill the safety requirements of toys. The substitution of phthalates to other compounds to be used as plasticizers will require of the potential candidates the following considerations: During the process:- A high compatibility with the resin- The material must present an appropriate rheology- The material must have an appropriate behavior at high temperatures to avoid degradation. The materials must present a good behavior to the mould release. On the finished product:- The study of volatility and migration of plasticizer in the final product with the double effect of a possible damage to the child and/or the piece.- The effect of living agents (mildew, bacteries, etc...) on the plasticizer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Phenotypic characterisation of nogo deficient mice.' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Nogo has been shown to be a major inhibitor of regeneration in the adult CNS acting with a potency similar to MAG. Studies with the function blocking IN- 1 monoclonal antibody have allowed a limited investigation of the role of Nogo-A. Technical difficulties with antibody delivery, stability and specificity limited the scope of these studies. A definitive understanding of its full role can only come from the performance of lesions in animals in which the Nogo gene has been inactivated. We are generating such animals and will be in a unique position to study them. The successful candidate will utilize skills in the performance of spinal cord and other CNS lesions and monitor the growth responses of surviving neurons. Studies will also be necessary to quantitate and characterize the expression of residual Nogo-C expression and analyze possible compensatory changes in the expression of other inhibitory components of myelin. We have extensive experience in a wide-range of technologies and training will be provided in molecular-biological characterization of knockout mice, analysis of neurite-outgrowth, purification of inhibitory components from the CNS and expression of recombinant inhibitory proteins. Work will be carried out in the Neurology Centre for Excellence in Drug Discovery. This department has an excellent track record in the training and development of post-doctoral fellows that has access to some of the best research facilities, equipment, technologies and highly trained and motivated staff available anywhere in the world.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tissue-specific mitochondrial signaling and adaptations to mistranslation' (MISTRANSMITO).

assistant: **Concept**

Mitochondria play a central role in the energy metabolism of our bodies and their defects give rise to a large variety of clinical phenotypes that can affect practically any tissue. The mechanisms for the tissue-specific outcomes of mitochondrial diseases are poorly understood. Mitochondrial energy production relies on two separate protein synthesis machineries, cytoplasmic and mitochondrial, but the mechanisms regulating the concerted actions between the two are largely to be discovered. Defects in either protein synthesis system that lead to accumulation of mistranslated mitochondrial proteins, intrinsic or imported from the cytoplasm, result in stress signals from mitochondria and in adaptive responses within the organelle and the entire cell. My hypothesis is that some of these signals and adaptive mechanisms are tissue-specific. My group will test the hypothesis by 1) generating and characterizing mouse models of cytoplasmic and mitochondrial mistranslation to be able to address our questions in different tissues. 2) We will develop methods for detection of ribosome stalling in mouse tissues to identify the consequences of mistranslation for individual proteins. 3) We will use systems biology approaches to identify stress signal responses to mitochondrial and/or cytoplasmic mistranslation using different tissues of our models, to identify those that are unique or global. 4) Our previous study has identified an interesting candidate responder to mistranslation stress and we will test the role of this factor in knockout animal models and by crossing with the mistranslation mice. I expect to gain important new knowledge of in vivo responses to mistranslation and execution of quality control. This proposal investigates key questions in understanding differential tissue
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'IMMERsive multi-modal interactive preSENCE', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The main objective of this Integrated Project (IP) is to enable highly realistic multi-modal interactive immersion into virtual and augmented reality environments. Its focus will be on visual, haptic and auditive sensory components, while addressing an even broader range of human senses. Hand-based interaction will serve as a prototypical framework, but the multimodal feedback of all relevant information will be considered.Three driving scenarios will cover the full spectrum of problems arising when implementing interactive environments: manipulation of an object by a human; direct contact between persons e.g. during a handshake or social dancing; and object mediated collaboration between humans, like jointly carrying a heavy object. These targets can only been reached by a concerted action, unifying competences in cognitive neuroscience, in psychophysics and in technology development. The indispensable scientific fundament will be established by basic research looking for new insights into the psychophysical and neurological mechanisms underlying multimodal interaction.A novel, data-driven algorithmic paradigm will be investigated for the generation of sensory feedback. During a first recording stage all relevant data characterizing interaction are collected by multimodal sensing suites. The recorded data will be processed in order to convert the raw signals into abstract descriptors. This abstraction will not only enable to faithfully replay the interactive session using the collected data while replacing the real counterpart by a virtual one, but will provide the fundament for prediction schemes to create sensory feedback for interaction which never has been observed before. The resulting prototype systems will be systematically evaluated by novel measures of presenc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Observation of beauty and quarkonia with the upgraded ALICE at the LHC', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Quantum Chromodynamics (QCD) predicts that at very high temperature and densities, ordinary matter undergoes a phase transition leading to a state of matter known as Quark-Gluon Plasma (QGP). The Properties of QGP can be investigated by heavy-ion collisions provided by the Large Hadron Collider (LHC) at CERN. The A Large Ion Collider Experiment (ALICE), the devoted experiment to investigate heavy-ion collisions at the LHC, is going through a substantial upgrade in 2019 and 2020 which is crucial to elucidate the properties of QGP by allowing the measurement of challenging probes like low pT heavy-flavor particles and quarkonium states and their coupling with the medium. HeavyQGP has the following scientific objectives: 1) perform analysis of ALICE data for quarkonia and beauty production; 2) ensure the quality of RUN3 ALICE data at forward geometries; 3) explore novel applications for the ALPIDE sensor; 4) operate the Muon Forward Tracker; 5) apply Open Science concepts at ALICE. HeavyQGP explores an innovative combination of expertise provided by the fellow (CPU architecture, computational physics, and nuclear instrumentation) and by the hosting institution (central involvement in ALICE Experiment and its upgrade) which improves the career prospects of the researcher while also supplying the host institution with key competences to initiate a high performance computing group on its premises and to fulfill its commitment to the ALICE upgrade program. A relevant secondment at CERN will offer the opportunity to the researcher to hold an active and prominent role in the ALICE experiment: System Run Coordinator for the MFT. This secondment will allow the high level implementation of the developments performed at the hosting institution, ensuring the continuity and disseminat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Resource allocation based on line measurement' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

We propose to investigate the technique of dynamic, on-line measurement and estimation of resource demand, rather than static modelling, to provide information to resource management systems. We will apply this technique to three distinct but related domains: public ATM networks, local area ATM networks and the operating system in end user computers. The goal is to develop measurement techniques and statistical estimators, and to demonstrate their utility in call admission and network dimensioning in ATM networks, and application resource negotiation in a multimedia operating system. Furthermore, we aim to provide a theoretical unification of resource management across the three domains. If our techniques can be used both in end systems and networks, then there is potential to tackle a serious problem facing distributed multimedia systems, namely the mapping of QoS attributes across the end system/network boundary.The project will approach the problem of measurement and resource allocation in the three domains, using equipment developed at Telia Research in a public ATM network scenario, equipment developed at Cambridge in a local area ATM network, and a multimedia operating system developed by the Pegasus ESPRIT project.The theoretical foundation of this work is large deviation theory, which enables us to derive, for a given system, a rate function which characterises the probability of rare events occurring (such as cell loss). The conventional approach to derive the rate function requires the traffic process to be statically characterised, by fitting model parameters to observed data. Our approach, however, estimates the rate functions directly from on-line measurements, thus bypassing the use of models, by exploiting a close analogy between large deviation rate func