RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Making hydrogen easy to deliver' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Hydrogen is an excellent energy vector with nearly 3 times more energy density by weight (120 MJ/kg) than gasoline. It plays a strategic role in energy transition, being essential to achieve the decarbonisation objectives. But the big challenge that hinders the deployment of hydrogen as a real solution for zero-emissions mobility is how to transport and storage big quantities in a safe and economic way.Our company HySiLabs has developed and patented an innovative hydrogen carrier called “HydroSil”, a liquid silicon hydride derivative, which is stable, non-toxic, non-explosive and non-dangerous. It enables to release hydrogen at the consumption site easily, on-demand and without any external energy input. Furthermore, it can be reused as many times as desired.HydroSil is aimed to big energy companies aiming to supply hydrogen to the market. This solution allows them to use the existing logistic infrastructure for fossil fuel, thus revolutionising the hydrogen delivery sector. Its high hydrogen content enables to transport 7 times more H2 per truck than with high-pressure H2 gas, drastically reducing the operational costs and the related emissions. Our innovation will have a disruptive impact in the mobility sector as it has the potential to remove the barriers that currently prevent a wide deployment of hydrogen-based applications by tackling safety, regulatory and supply chain issues. Moreover, HydroSil is a unique carbon-free solution, suitable for onboard applications in heavy mobility (trucks, trains, maritime, etc.).HySiLabs was created with the objective of developing and exploiting this new technology which is based in a recent scientific discovery. Properly industrialised, it has all the ingredients to become a game changer in hydrogen distribution industry, enab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Preventing Alport syndrome with a natural amino acid'.

assistant: **Innovation**

Chronic kidney disease (CKD) is a major burden on society, causing significant morbidity and mortality. A typical symptom of CKD is the loss of protein into the urine, also termed proteinuria, which is usually associated with a poor prognosis. In most cases, a defective glomerulus leads to proteinuria, resulting in damage of the neighboring proximal tubular cells due to protein and lipid overload. In RENOTREAT, we aim to treat Alport syndrome with a natural amino acid, that is known to inhibit the tubular protein uptake receptors cubilin and megalin. This amino acid is already available as a safe treatment in humans, but has never been used for kidney disease. Alport syndrome is a rare disease with underestimated prevalence. It is caused by defective collagen fibers due to pathogenic genetic variants in collagen IV genes. The lack of functional collagen fibers leads to a more permeable glomerular basement membrane, resulting in proteinuria with subsequent proximal tubular damage. In our therapeutic strategy, we will induce tubular proteinuria by blocking protein uptake into the proximal tubule, overturning the paradigm that the degree of proteinuria correlates with kidney damage. First, we will test dosing regimens and bioavailability for three different formulations of the amino acid with regard to the induction of a stable tubular proteinuria in wild-type mice. Using a murine model of Alport syndrome, we will then evaluate these treatments for their potential to slow CKD progression and prolong the survival of the mutant mice. In parallel, we will conduct a pilot trial in healthy human volunteers with the already available form of the amino acid to prepare for a future clinical trial in Alport patients.In summary, we will verify the innovation potential of a novel the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Integrated Models of Airlines for a Green Impact on the New Economy'.

assistant: **Concept**

Project IMAGINE aims at developing operational constraints and cost models representative of airline operations.As part of the MTM activity of CleanSky’s SGO ITD, these models will be integrated in the GATAC Optimization framework to add the operational and economics dimension to the multi-criteria optimization of flight trajectories.IMAGINE will develop models for:- Operational constraints (aircraft and operations limitations, minimum turn-around time, etc.)- “Basic operations costs” (Aicraft ownership, maintenance, landing and navigation, overhead, etc.)- Environmental costs (ETS, airport emission charges, noise charges…)- Crew costs- Fleet and schedule related costs, including revenue opportunities and lossesThe originality of IMAGINE relies in:- The ability to address all the costs with different models: simulation based, statistics based and OR based- The ability to handle fleet-wide problems in a single optimization run and take into account interactions between the flights (for example for crew pairings and schedule impacts)- The ability to propose near-exact models (with high accuracy but requiring many airline parameters) or approached models based on the innovative surface response methodology, which is well adapted to a generic optimization framework such as GATAC- The validation of the models against real airline data exploiting different types of aircraft: regional turboprops, single-aisles and widebodies.- The ability of the consortium to deliver industry-level object oriented code for the implementation of the model.The consortium involves 2 SMEs with extensive experience in aviation, environment and the development of costs models and optimization engines used daily within different models of airlines.Finally, the participants have experience in handling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The evolution of human gut microbiomes in the plastics era' (2021-2027) under Horizon Europe.

assistant: **Objectives**

The gut microbiome (GM) is essential to human health and its dynamics allow for compositional and functional changes, giving it the potential to help hosts to adapt to rapidly changing environments. Although there is growing concern and public pressure to understand the impacts of increased plastic pollution on human health, a detailed assessment of this xenobiotic’s impacts on GMs is a major gap in research that this proposal seeks to bridge. I hypothesize that given (a) human exposure to plastics began very late in human evolution at the turn of the 20th century, (b) this exposure is ever increasing, and (c) preliminary results from my previous research show associations between plastic ingestion and changes in GM diversity and compositions, then plastics likely play a role in shaping GMs and their functions in modern humans. I aim to test this hypothesis by (1) determining the prevalence of plastic-degrading (PD) microbes and functions across modern GMs in order to (2) validate and characterize in vitro a subset of candidate gut microbes’ capacity for previously unidentified PD to finally (3) investigate plastics as a modulator of modern GMs. This will unveil unexplored factors behind the evolution of human gut microbiomes that could lead to the discovery of new plastic degrading microbes relevant for plastic pollution remediation strategies. This project takes an unconventional and multidisciplinary approach by exploiting advances in microbiome research encompassing bioinformatic tools and databases, applying these to the plastics field, and targeting humans. By building on my existing skills in wildlife and microbial ecology and plastics research and expanding them into human and computational metagenomics (strengths of the host), I am confident that plasticOME wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'StUDY OF THE NOVEL ENVIRONMENTALLY FRIENDLY SYNTHESIS OF GUAIACOL' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Current guaiacol synthesis technology is not environmentally fricndly, involves high plant capital costs and results in the production of hydroquinone as a bi-product. Hydroquinone synthesis is now carried out in the USA which makes the co-production technology inappropriate. The study will aim to increase process safety: reduce process costs by up to 20 %: control the process to produce a single intermediate: reduce the capital costs of the plant by up to 50 %: and reduce waste and pollution to a minimum. The RTD goals to meet these aims are: eliminate the use of phenol (highly toxic); eliminate the use of methyl chloride with subsequent elimination of chloride waste; exploit some alternative chemistry based on cyclohexene, using novel catalysis improve on the current very low conversion rate. It is intended to do this by the studs of novel synthesis routes of guaiacol as the main product, in an environmentally way.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Public SAfety & CommeRcial Info-Mobility Applications & Services in the MOUNTains' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Hiking is one of the major sporting activities in mountainous regions, e.g. the Pyrenees or Alps. PARAMOUNT is a project funded within the European Commission IST fifth framework program with the main objective to develop a prototype for an info-mobility service for mountaineers and hikers. Therefore a combination of telecommunications (GSM/UMTS) and satellite navigation (GNSS) with geographic information systems (GIS) is used for delivering various information to the user and increasing the safety of the user. The two major components of the system are a mobile device carried around by the user and a set of services provided by the PARAMOUNT servers. The communication between those two components will be assured by state of the art telecommunication technologies. Furthermore research will be made on the regional availability of GSM, GNSS and GIS data in the Pyrenees and Alps to identify regions in which such a service could be tested and commercially exploited.Objectives:PARAMOUNT aims at developing a prototype for a user-friendly info-mobility service for over 150 Mio mountaineers in the EU by combining telecom (GSM/UMTS) and satellite navigation (GNSS) with geographic info systems. A mobile digital TourGuide (a smartphone like) device which is carried around by the users and several server based functionalities will allow them to use the following services and features. Communication between the mobile component and PARAMOUNT servers will be based on state of the art technology (e.g. GPRS).The services offered to hiker's include:- Download and visualization of appropriate maps depending on the current user's position;- Displaying the user's position on the map as well as numerically;- POI (e.g. huts) and additional information about them;- Offering routing assistance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Nurturing Environment - BioPrinting Human Renal Organ Networks'.

assistant: **Innovation**

Chronic kidney disease (CKD) results in loss of kidney function in patients, ultimately requiring organ transplant. Critical organ shortage and organ rejection after transplant make extended dialysis inevitable and the only therapy available. To exacerbate this problem, the incidence of CKD is increasing worldwide, with >14% of the general population affected. Hence, there is an urgent need for novel therapies. Induced pluripotent stem cells have been used to create kidney organoids representing early renal development stages. These organoids might be a suitable therapy in the future but fundamental challenges to achieve late stages of physiologically relevant maturation and function need to be addressed. The lack of vasculature and collection duct systems limits the viability and filtrate removal. To overcome this challenge, I aim to develop a novel, mature in vitro kidney model by exploiting different bioprinting technologies combined with organoid knowledge. This solution will include a bioengineered kidney extracellular (ECM) microenvironment, a vascularized network and a collecting duct system. I hypothesize that the strategic combinations of different bioprinting techniques will allow the development of key structures such as vasculature, essential for promoting maturation of the in vitro model, and a collecting duct for filtrate collection with an expected increase in function resembling the organ. Finally, the combination of the different modules on a microfluidic platform will allow the accurate control of the organoid perfusion and long-term cultures. NEPHRON will allow further knowledge on bioprinting functional kidney units while providing scientists an improved in vitro model to study development, disease and regeneration of the kidney. This knowledge can l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ENERGY EFFICIENT, SPACE EFFICIENT and COST-EFFECTIVE DATA STORAGE SYSTEM FOR HEALTHCARE' (BasePort), addressing dissemination and exploitation.

assistant: **Impact**

The promise of Precision Medicine that was envisioned decades ago with the mapping of the human genome is fast becoming a reality. While genomic research is paving the way for significant advances in healthcare, its practice has led to new challenges for biotechnology firms in terms of increasing data volume, variety and complexity. Given that the data representing a single human genome takes up to 100 gigabytes of storage space, biotech companies engaged in genomic research must develop the computing infrastructure and skills to manage, store, analyse and interpret massive quantities of highly complex data. Healthcare centres, in particular, need a data storage solution that uses low power, small space, small volume, low weight, and is quiet, and easy to implement. It is quite a challenge for an inner-city hospital to construct and operate a data centre like those built by Google, Amazon, & Microsoft. Current alternatives are either too costly, or exhibit low reliability and/or performance, and none of them achieve the right level of security. In answer to this need, Swiss Vault is developing a high-density, modular genome sequencing/storage proprietary system, which enables organisations to scale their data capabilities in terms of both computing power and storage with high security and low carbon footprint. The BasePort project will allow us to bring to market a data storage hardware integrated with software that operates with 1/10th power consumption, 1/4th volume, and 1/5th weight of conventional comparable systems. The innovative form-factor is 10X more power- & 20X more space-efficient, easy to manage, ideal for Industry 4.0, Smart Cities and Edge computing. Our platform makes data storage a “Green Technology” and enables organizations to reduce their data storag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Axon survival: the role of protein synthesis' in the context of a Seventh Framework call.

assistant: **Objectives**

Neurons make long-distance connections with synaptic targets via axons. These axons survive throughout the lifetime of an organism, often many years in mammals, yet how axons are maintained is not fully understood. Recently, we provided in vivo evidence that local mRNA translation in mature axons is required for their maintenance. This new finding, along with in vitro work from other groups, indicates that promoting axonal protein synthesis is a key mechanism by which trophic factors act to prevent axon degeneration. Here we propose a program of research to investigate the importance of ribosomal proteins (RPs) in axon maintenance and degeneration. The rationale for this is fourfold. First, recent genome-wide studies of axonal transcriptomes have revealed that protein synthesis (including RP mRNAs) is the highest functional category in several neuronal types. Second, some RPs have evolved extra-ribosomal functions that include signalling, such as 67LR which acts both as a cell surface receptor for laminin and as a RP. Third, mutations in different RPs in vertebrates cause unexpectedly specific defects, such as the loss of optic axons. Fourth, preliminary results show that RP mRNAs are translated in optic axons in response to trophic factors. Collectively these findings lead us to propose that locally synthesized RPs play a role in axon maintenance through either ribosomal or extra-ribosomal function. To pursue this proposal, we will perform unbiased screens and functional assays using an array of experimental approaches and animal models. By gaining an understanding of how local RP synthesis contributes to axon survival, our studies have the potential to provide novel insights into how components conventionally associated with a housekeeping role (translation) are linke
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cell entry of influenza a virus and human cytomegalovirus' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Outbreaks of influenza A in humans, birds and animals constitute a continuous major threat to public health as influenza A viruses are capable of species shifts and enormous genetic variation. More than two decades ago, influenza entry was described to occur by endocytosis via clathrin-coated pits. Some evidence was also found for an alternative, clathrin-independent endocytic pathway, but it has not received attention until recently. I will focus on the novel, alternative process. Another virus becoming clinically more important, human cytomegalovirus (hCMV), can be detected in over 80% of the worlds population. Although most humans keep a latent infection without any symptoms, the virus can be reactivated in immuno-compromised individuals. Furthermore, severe mental defects as well as deafness can occur in case of congenital infection of newborns which is up to 1% of all newborns in the USA.The endocytic entry mechanism of hCMV is largely unknown. Only recently specific integrin-subunits were identified as receptors. I propose to investigate the entry mechanism of hCMV in more detail. In general, the whole analysis will be carried out in a comparative manner to two already quite well studied model pathogens, namely simian virus 40 (SV40) and semliki forest virus (SFV). Experimentally, I will investigate the behaviour of individual, labelled viruses in and on cells using state of the art life-cell-imaging microscopy. I will set up screening assays for influenza A and hCMV infection applying siRNAs in a loss of function screen. Construction of stable cell lines harbouring a conditional RNAi / shRNA knockdown system targeting the clathrin-dependent uptake mechanism will enable me to separate the pathway from the parallel clathrin-dependent pathway.These result s are expe