RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The pluton-volcano connection: Integrating processes, volumes and time scales in magma plumbing systems' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Volcanoes frequently affect our lives and thus have been studied since people started living and farming on their nutrient-rich, ash-covered flanks. The processes that cause eruptions also control the compositions and volumes of erupted material and ultimately the eruption styles. These processes and the time scales at which they operate are not well understood. Part of the reason is that many processes controlling eruptions occur in magma reservoirs deep below the volcano. These reservoirs are not easily accessible until they are solidified forming plutons and exposed millions of years later, when volcanic cover rocks are removed through uplift and erosion.The proposed study will, for the first time, integrate research on a fully exposed magma plumbing system in Colorado, USA. Here, volcanic materials are juxtaposed with their plutonic equivalents. The broadly educated applicant, who has carried out field, geochronology and geochemistry studies of plutons in the USA, is teaming up with the host, who has focused his research on volcanic rocks worldwide. The idea is to converge their respective expertise and conduct an interdisciplinary, multilevel analytical study on both volcanic and plutonic rocks. Research will commence with field work, petrographic studies and determination of relative ages. The main element of this study employs novel mineral-scale analyses of crystals from both rock types. The recovery of geochemical information from single crystals, in particular, will be used to provide a record of the processes and timescales operating during magma evolution. The host institution at Durham University has built a state-of-the-art geochemical laboratory for single mineral studies where such detailed crystal scale information recorded during crystal growth can be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Targeted inhibition of TRRAP as a strategy against aggressive brain cancer', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Patients with aggressive brain cancer have a very poor prognosis with an average life expectancy of only ~12 to 17 months. High grade brain tumors are extremely difficult to treat due to tumor cell invasion, plus resistance of tumor cells to DNA-damaging therapy. This cellular aggressiveness within brain tumors has been attributed to a subpopulation of tumor cells that possess stem cells-like features.Unlike differentiated tumor cells, brain tumour stem cells (BTSCs) possess the ability to self-renew, to withstand DNA-damaging therapy, and to give rise to new tumor mass. Therefore, targeting BTSCs is expected to improve the efficiency of anti-brain cancer therapy. In particular, targeting pathways that sustain the undifferentiated state of BTSCs is a novel strategy to treat aggressive brain tumors. However, this approach is hampered by a poor understanding of appropriate targets promoting the BTSC phenotype.Recently, we have demonstrated that the adapter protein TRRAP maintains BTSCs in an undifferentiated and highly tumorigenic state. Consistently, elevated expression of TRRAP in human brain tumors has a strong negative effect on patient survival. Therefore, we aim to provide a basis toward the development of an effective therapeutic strategy against the malignant function of TRRAP in BTSCs.To this end, we will use our established BTSC assay system and BTSC in vivo models in combination with differential proteomics to characterize TRRAP protein domains and TRRAP-protein interactions that critically promote the BTSC phenotype. Moreover, we will investigate the role of TRRAP during brain tumor invasion and potential additive effects between DNA-damaging therapy and inhibition of TRRAP function in vivo.Overall, these interrelated approaches will validate TRRAP as a brain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Carbon Offset Plug-in' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Carbon Checkout is a technology company that facilitates carbon offset transactions through eCommerce and mobile channels. We integrate our carbon finance software application into partner sites and mobile platforms to enhance the customer experience with a sustainable purchasing option – an option to offset the carbon footprint of their purchase, in one-click at checkout.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Use of BioEngineered Plant-Integrated Cover (BioEPIC) to Enhance Slope Performance' (BioEPIC).

assistant: **Concept**

Climate change threatens the stability of infrastructure slopes, which form a large proportion of the European transport network. Slope failures due to increasing intense rainfall have already resulted in significant socio-economic loss across the Europe. Slope revegetation is identified as a more environmentally friendly and aesthetically pleasing stabilisation technique, when compared to other high-embodied-CO2 methods such as sprayed concrete cover. However, there are series of research questions at the interface of unsaturated soil mechanics and plant biophysics relating to this application that, if answered, will allow better engineered and widespread deployment of this ‘green’ solution. Many of these questions relate to the effects of plant transpiration on slope stability. The key aims of this project are to improve the understanding of soil-water-plant interaction, and then to apply the improved knowledge to quantify the performance of BioEngineered Plant-Integrated Cover (BioEPIC) slopes under a changing European climate. Through laboratory testing, parameters controlling root-water uptake will be identified, and they will be used to interpret the responses of BioEPIC slopes observed from scaled centrifuge tests. By “vegetating” novel “transpiring” root models to BioEPIC slope in the centrifuge, plant effects on long-term slope failure mechanisms will be investigated. This will create a high-quality database that will give engineers increased confidence in adopting BioEPIC to mitigate slope stability problems anticipated under climate change. Through the CIG, this project will generate original findings that will provide the first step for the applicant (who is holding his first permanent academic appointment in Europe) to build his research team as an integrat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel Energy Materials: Engineering Science and Integrated Systems (NEMESIS)' (NEMESIS) targeting Seventh Framework.

assistant: **Abstract**

The aim of NEMESIS is to establish a world leading research center in ferroelectric and piezoelectric materials for energy harvesting and energy generation. I will deliver cutting edge multi-disciplinary research encompassing materials, physics, chemistry and electrical engineering and develop ground breaking materials and structures for energy creation. The internationally leading research center will be dedicated to developing new and innovative solutions to generating and harvesting energy using novel materials at the macro- to nano-scale.Key challenges and novel technical approaches are:1. To create energy harvesting nano-generators to convert vibrations into electrical energy in hostile environments (e.g. wireless sensors in near engine applications).2. To enable broadband energy harvesting to generate electrical energy from ambient vibrations which generally exhibit multiple time-dependent frequencies.3. To produce Curie-temperature tuned nano-structured pyroelectrics to optimise the electrical energy scavenged from temperature fluctuations. To further enhance the energy generation I aim to couple thermal expansion and pyroelectric effects to produce a new class of thermal energy harvesting materials and systems.4. To create nano-structured ferroelectric and piezoelectric materials for novel water-splitting applications. Two approaches will be considered, the use of the internal electrical fields present in ferroelectrics to prevent recombination of photo-excited electron-hole pairs and the electric charge generated on mechanically stressed piezoelectric nano-rods which convert water to hydrogen and oxygen.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Diagnostic Applications of Synchrotron Infrared Microspectroscopy' (DASIM).

assistant: **Concept**

The purpose of this proposal is to advance diagnostic applications of infrared microspectroscopy and functional imaging using synchrotron light sources. Existing networks between biologists, clinicians and synchrotron scientists are already making impressive progress in IR microspectroscopy of cells and tissues leading to the identification of spectroscopic markers of diagnostic relevance. However, the European dimension is missing in these efforts because very few countries have synchrotron IR microspectroscopy facilities. In order to further explore and advance the diagnostic possibilities of infrared microspectroscopy and imaging using synchrotron sources, there is a need to coordinate this research effort by networking the existing centers of excellence on the European scale and adding further necessary multidisciplinary expertise. This includes promotion of access to synchrotron facilities for experts from countries without their own facility, especially candidate countries. Management aspects are important in this proposal, in order to avoid wastage through duplication of effort, to promote methodological validation by adding a multicentric quality control perspective, and thus to facilitate transfer of this emerging technology into clinical practice. To this end, we plan a disease-oriented, clinician-driven approach rather than a technology-driven approach. The overall goal of the proposal and chief deliverable will be a report assessing the potential of synchrotron IR microspectroscopy for diagnosis on a per-disease basis, and making recommendations for further action in the sense of defining the future Framework Programme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Top Partners at the LHC' (PARTNERS) under Seventh Framework.

assistant: **Objectives**

The objective of this proposal is a thorough study of the minimal LHC phenomenology of partners of the top quark and other standard model particles. The existence of these partners is a prediction of many approaches to solving the hierarchy problem: that is, the question of why the mass of the Higgs boson is small compared to fundamental scales in physics. In essence, the role of these new partners is to cancel quantum corrections to the Higgs mass which arise from standard model particles. The top quark is responsible for the largest correction to the Higgs mass in the standard model, and therefore the mass of its partner is expected to be well within the experimental reach of the LHC.Theorists have proposed a variety of models which solve the hierarchy problem. Some of these models have been studied in detail but others have not. This proposal will fill the holes in our knowledge of what physics at the LHC will look like if there is a solution to the hierarchy problem in nature. The approach will be very general, focusing on effective field theories which incorporate approximate cancellations of the corrections to the Higgs mass. We will identify and describe experimental signatures of the models and validate these signatures by numerical simulations. We will also investigate the question of whether new developments in the understanding of scattering amplitudes open new methods for discovering the new symmetries which are usually required to cancel the quantum corrections.In addition to the value of this research, the proposal will contribute to the competitiveness of European science by transferring knowledge of particle physics from the US to Europe. This knowledge transfer will occur through mentoring students; teaching courses and public outreach activities. The r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'In vivo drug discovery for cellular reprogramming to β-cells  – towards a future regenerative therapy for diabetes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

For almost a century we have been able to control diabetes with insulin injections, yet we still have no cure for this prevalent disease. One possible way to cure diabetes is by increasing the number of insulin-producing β-cells in the pancreas. Here, I propose to uncover factors and mechanisms that can increase β-cell numbers through cellular reprogramming. To do so, we will use two complementary discovery approaches—and transition between zebrafish, mouse and human analyses—to perform functional studies with high translational value.First, we will use a novel drug discovery approach in transgenic zebrafish to identify and characterize small molecules that can promote the reprogramming of various pancreatic cell types to β-cells. Second, we will use single-cell RNA-sequencing to identify genetic signatures of cellular reprogramming to β-cells in humans, and then dissect the function of the identified genes by overexpressing or mutating them in transgenic zebrafish. We will also use lineage-tracing to determine the number and origin of the β-cells the small molecules and genes induce. Once we identify promising hits in zebrafish, we will treat diabetic mice with small molecules or secreted proteins (targeting the signalling pathways regulated by the hits) and evaluate their effects on glucose control and β-cell mass. We will also test their effects on cellular reprogramming in mice, as indicated by changes in the relative proportion of each hormonal cell type, in the generation of bihormonal cells (insulin+ glucagon+ or insulin+ somatostatin+), and in the number of lineage-traced β-cells. Further, we will determine whether these small molecules or secreted proteins induce reprogramming to β-cells in human islets. By coupling whole-organism screens with mechanistic and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Multifunctional Nanoparticles and Materials Controlled by Structure' (NANOMATCON).

assistant: **Concept**

Multiscaled structure-tuned materials with exactly predefined hierarchical architectures composed of multifunctional nanoparticles represent a class of the most advanced future materials for applications in nanobiotechnology, nanomedicine, lighting technologies, green energy resources as well as in military and security branches. The CxI Centre in Liberec will expand its current activities in the field of nanomaterials and engineering technologies by integrating  multiscaled 3D-printing machines combined with wet nanochemistry robotics in order to create the aforementioned breakthrough materials. These activities fully correspond to the agenda defined in Horizon 2020. The project belongs to the CEP themes of composite materials (JI), biotechnology (EI) and non-nuclear energy, consumption and utilization of energy (JE).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Total Diet Study Exposure' (TDSEXPOSURE).

assistant: **Innovation**

Total Diet Studies (TDS) allow getting information on real dietary exposure to food contaminants consumption (heavy metals, mycotoxins, POPs...) and estimating chronic exposure to pesticide residues in food and food additives intake. TDS consider total exposure from whole diets and are based on food contamination as consumed rather than contamination from raw commodities, thus ensuring a realistic exposure measure.TDS facilitate risk assessment (RA) and health monitoring (HM). Some EU Member States (MS) and Candidate Countries (CC) have no TDS programme or use various methods to collect data, which were not examined yet to tell whether they are comparable or not. This is of interest for EFSA or WHO-FAO. Similarly it is important to harmonise methods to assess dietary exposure risks in MS, CC and at the European level compared with other world regions.The methods proposed will aim for food sampling, standard analytical procedures, exposure assessment modelling, priority foods and selected chemical contaminants consistency across MS and CC. Various approaches and methods to identify sampling and analyses will be assessed and best practice defined. Contaminants and foods which contribute most to total exposure in European populations will be defined.Priority will be given to training and support in EU MS and CC currently without TDS. It will demonstrate best practice in creating a TDS programme using harmonised methods in regions previously lacking TDS, and ensure consistency of data collected. A database will be set up describing existing EU studies and collating harmonised exposure measures and designed to allow risk assessors and managers handling dietary exposure more accurately and more specifically.TDSEXPOSURE will spread excellence in TDS throughout stakeholders and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Spectra- A novel diagnostic device to improve retinal imaging' (Spectra) targeting Horizon 2020.

assistant: **Abstract**

Health Intelligence provide medical software as diagnostic medical devices. We have developed retinal (fundus) photograph analytical software - Spectra, complemented by the lower cost, standalone and portable Spectra Retineye. Spectra is one of only three software packages certified by the English National Diabetic Retinopathy (DR) Screening Programme. It has benefitted screening providers by seamless integration with patient records and ability to monitor over time. Providers reported improved throughput and attendance.  Spectra highlights much more than just DR. In deployments to date, over 50% of urgent eye clinic referrals are for suspected non-diabetic retinopathies. Thus, Spectra detects reliable biomarkers for many conditions. The greatest causes of blindness (after cataracts) are glaucoma, age-related macular degeneration and DR. Spectra can detect early and treatable stages of these diseases, in particular low-pressure glaucoma missed by ocular pressure tests. New markets also exist for diabetic eye screening programmes (DESP) in countries lacking the resources of the UK NHS. Teleopthalmology (enabled by Spectra Retineye) could deliver these.   Both Spectra and Spectra Retineye can deliver economic benefits:•Reducing need for expensive equipment and highly-qualified staff•Portability •Increased footfall in high-street optometrists from eye screening patients •Easier and lower cost of screening to patients •Reduced social security costs due to sight loss Spectra will deliver tremendous social benefits. Preventable, irreversible sight damage will become rarer, reducing sickness and caring burdens. Spectra Retineye, which is eminently adaptable to teleopthalmology will allow more delivery models. These will detect more problems earlier, including the 46% of diabet