RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Novel bi-lamellar lipid vesicles for studying double-membrane transenvelope proteins' under Horizon 2020.

assistant: **Concept**

Double membranes are ubiquitous throughout the domains of life, accommodating remarkable protein machineries which are fundamental to the cellular activity. However, the study of these proteins is restricted by the lack of a suitable membrane model to accommodate them. Within the framework of BiLamVesicles I will develop a novel bi-lamellar lipid vesicle as a tool for hosting and studying proteins which naturally span across double membranes such as the nucleus and Gram-negative bacteria envelopes. To integrate the protein of choice within the vesicle envelope I will design and employ a highly regulated layer-by-layer assembly in a microfluidic chip. This approach will combine the host’s expertise in microfluidics and biophysics with my expertise in surface interactions and surface chemistry to allow an exquisite control over the membrane composition of bi-lamellar vesicles and the protein insertion process. Once assembled, I will use these vesicles to study the activity of the entire Gram-negative bacterial transporter system AcrAB-TolC, an archetype multidrug efflux pump of Escherichia coli. I will spatially isolate vesicles in a microfluidic chip and directly quantify transport rates through a full efflux pump system at the single-vesicle-level for the first time, using an advanced optofluidic system. The synergy between microfluidics and the proposed double membrane vesicles will produce a ground-breaking biotechnological technique for studying the activity of as yet inaccessible proteins in a biologically-relevant environment. This research will stretch the existing boundaries set by current membrane models and will pave the way for developing advanced techniques for drug screening assays.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'SUStainable INsect CHAIN'.

assistant: **Concept**

The expected global population growth to 9.1 billion people in 2050 and the significant change of global dietary patterns require increasing world-wide food production by about 60%. The protein supply for feed and food is most critical, and requires a transition in protein sources. Edible insects can upgrade low-grade side streams of food production into high-quality protein, amino acids and vitamins in a very efficient way. Insects are thus considered to be the “missing link” in the food system of a circular and sustainable economy. Insects and insect-derived products have entered the European market since first being acknowledged as a valuable protein source for feed and food production at around 2010. However, scaling up the insect value chain in Europe is progressing at a relative slow pace. The aim of this project is to contribute to novel protein provision for feed and food in Europe by overcoming the remaining barriers for increasing the economic viability of the insect value chain and opening markets by combining forces in a comprehensive multi-actor consortium. The overall project objective is to test, pilot and demonstrate recently developed technologies, products and processes, to realise a shift up to Technology Readiness Level 6 or higher. The project focuses on these crucial activities, as well as living labs and workshops with stakeholders in the insect protein supply chain for feed and food. These actions provide the necessary knowledge and data for actors in the insect value chain to decrease the cost price of insect products, process insects more efficiently and market insect protein applications in animal feed and regular human diets that are safe and sustainable. This will pave the way for further upscaling and commercialisation of the European insec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Vehicle integral simulation for pass-by noise reduction (an innovative step towards low noise traffic emissions) (visper)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Pass-By Noise (PBN) generated by road vehicles is one of the most relevant environmental issues, in particular for urban areas. The reduction of the PBN relies on experimental work considered in a late stage of the vehicle development process, as today no reliable prediction tool is available. Thus, noise reduction procedures are extremely time/cost intensive and don't lead to optimised low noise vehicle concepts. To contribute for the solution, Hybrid Engineering Tools (simulation test) for the PBN prediction are proposed. A novel methodology and prediction system will be developed in order to assess possibilities for future low noise vehicles. To demonstrate the validity of the developed prediction methodology, a 3 dB (A) target for noise reduction has been defined for two demonstrator vehicles modifying the power train and exhaust/ intake systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Marine sponges as models for assessing biological effects of the Mediterranean Sea warming' (BIOWARM).

assistant: **Concept**

Potential effects of global change act at different organisation levels from physiological to community level and can ultimately lead to a significant diversity loss and affect ecosystem functioning. Some of the expected effects of the global warming have already been detected in the NW Mediterranean, although not all have been related to a global change scenario. Moreover, many effects could be already acting but not yet visible though resulting in important phase-shifts events in the near future as observed in other habitats. Bearing in mind that the Mediterranean occupying only a 0.82 % of oceans surface harbours between the 4 to 18 % of marine biodiversity, potential effects of global change could have dramatic consequences for marine diversity conservation. Among the most severe impacts on marine biodiversity, a mass mortality occurred in the NWMediterranean in summer 1999. This event affected 30 species of invertebrates from 5 differentphylums, the most affected taxi being sponges and cnidarians. This mass mortality took place under an abnormal environmental context characterised by high and stable water column temperatures. In such conditions, the impacted invertebrates have probably reached their higher thermo tolerance, the exposure time having lethal consequences either directly, leading to some physiological depletion, and/or indirectly by triggering the virulence of pathogens. The main objective of the proposed programme is thus to better understand the cause of such mass mortality from an ecophysiological point of view and to propose bio indicators of the Mediterranean warming trend. It can be reasonably argued that biodiversity loss or widespread mortality manifests itself long after biochemical dysfunction, physiological abnormalities, and growth or repro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mastering Electronic Doping in Tin-Halide Perovskites to Develop Near Infrared Light Emitting Diodes' under Horizon Europe.

assistant: **Concept**

As a key advancing technology, near-infrared light-emitting diodes (NIR-LEDs) cover nearly all aspects of our daily life due to their supported large applications, such as biomedical imaging, optical communication, security, and data storage. With extensive efforts, the efficiencies of LEDs have been improved by over 20% in the emission range below 800 nm. However, the development of NIR-LEDs over 800 nm is modest due to the fundamental limitation of emitters. Recently, tin-halide perovskites (THPs) have emerged as one of the most promising candidates for NIR-LED application. Through easy composition engineering, the emission of THPs can be readily tuned from 680 nm to 1000 nm. Meanwhile, the low-toxic Sn-based perovskites follow the requirements of the European Green Deal, which ask for reducing pollution to enhance the protection of human life, animals, and plants. However, the excessively high p-type doping in THPs, which reduce the carrier injection efficiency and radiative recombination efficiency, currently limits the development of THP-based NIR-LEDs. This project (MaDLED) will promote the development of NIR-LEDs by developing novel strategies to increase carrier injection and recombination efficiency. The results of this project will advance the knowledge about NIR emissive semiconductors, and be of value in other fields, such as solar cells, detects, transistors, etc. This will be achieved by integrating deep knowledge of materials science with expertise in advanced optical-electronic spectroscopies in the host (Istituto Italiano di Tecnologia, Italy). Besides, a secondment (Helio Display Materials, United Kingdom) is planned to define a suitable route to industrialization. After training in this project, I will have an increased set of research and transferabl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Enthusiasm, Passion, Inspiration, Challenge (EPIC) – join us during the Researchers’ Night and see for yourself how by connecting science and passion one can make a difference!' (EPIC) under Horizon 2020.

assistant: **Objectives**

Researchers’ Night again in Poznan! EPICNight! Enthusiasm, Passion, Inspiration, Challenge– join us during the Researchers’ Night and see for yourself how by connecting science and passion one can make a difference! Come and uncover the secrets of scientists and researchers! Open the doors to your good neighbours – researchers! Measure immeasurable and see invisible! Become a researcher for one night and construct DNA helix, have a ride in 3D helmet, design your own clothes or learn the secrets of Eco-robots! Come and sing karaoke songs with researchers and at the end dress up like a famous scientist and dance with us cha-cha or jive. Feel like doing some sport? These and many other attractions are waiting for you to reveal your passion for science and convince you that researchers are just ordinary people with an extraordinary job and various hobbies!EPICNIGHT is a continuation of the Researchers’ Night projects of the past seven years, which were highly successful gathering last year app. 57 000 people willing to meet researchers face to face and to learn new things about their work and personal lives. The project, promoting an image of researchers, builds on last years’ experiences and aims at enhancing further public recognition of researchers and their work by bringing them closer to the public, underlying their important contribution to the daily life and well-being of the European citizens. Activities organised during the Night on 26 September 2014 and 26 September 2015 will be focused on public at large and will have even more hassle-free and festive character, being a valid alternative to ""traditional Friday night activities"" while allowing learning more about researchers and research. Those activities will offer a direct contact between researchers and publi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '10th International Conference on Bioinorganic Chemistry' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

ICBIC meetings are a series of conferences, which was ideated by Ivano Bertini in 1983 to gather together scientists from all over the world working in the field of inorganic chemistry applied to biological systems. After the first edition held Florence, the success of these meetings, as well as the number of scientists dealing with biological inorganic chemistry, has steadily grown. The International Organizing Committee has decided to have back to Florence the 10th ICBIC. As in the tradition of these meetings, the scientific program is designed to cover all aspects of bioinorganic chemistry such as model chemistry, metalloproteins and metalloenzymes, DNA/RNA/nucleotides and metals, radicals and life, signal transduction, from the gene to ion uptake and release, metal-based drugs, environmental biotechnology.Particular attention will also be devoted to the physical methods of interest to this discipline. As a sign of innovation with respect to the past, the Neon Jubilee" edition of the International Conference on Bioinorganic Chemistry aims at framing all the various aspects of the research in the new field of post-genomic research. The availability of the complete genome of an increasing number of organisms is indeed deeply influencing the approach of those working in the field of biological sciences. The short-term benefits expected from post-genomic research will be a deeper understanding of processes at the basis of life. On the long run results from post-genomic research are expected to contribute to drug-design, selective and harmless therapeutic strategies, to diagnosis of genetic disease and cure of tumours. Bioinorganic chemistry is expected to have a fundamental role in this future development of science and special sessions at the conference will be explicit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'The european biological resource centres network'.

assistant: **Concept**

The project will address important issues raised by the current OECD Initiative on Biological Resource Centres (BRCs) requiring culture collections to adapt to support biotechnology for the 21st century. It will allow Europe to exploit its expertise in BRCs and Information Technology, set common policies and maintain high standards of operation. It will allow links to be made between the BRC catalogues and other data sets and ensure that the large amount of specialised information that is presently hidden in BRCs is brought into the open and will utilise a single common web site as its electronic centre. Importantly, it will coordinate response to new initiatives relevant to access to, and use of, microorganism and cell line ex situ living resources. It will improve collection capacity and enable cost-effective introduction of new technologies by improving efficiency through co ordination of common activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Keratinocytes and Matrix metalloproteinases: driving force of skin wound contraction?' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Two unconventional concepts of skin contraction are presented that could change the current paradigm of wound healing. The overall objective is to clarify the underlying processes and to develop new therapies to prevent excessive scarring, ameliorate patients lives and reduce medical health care expenses. Specific emphasis lies on the role of Matrix metalloproteinases (MMP) and keratinocytes. Previous internationally acknowledged work of the PI resulted in these challenging concepts. The project will take place at the Medical School Hannover with its vast scientific infrastructure perfectly suited for this type of pioneer research. Unconventional is the concept that MMP lead to contrary cell responses. By degrading matrix molecules, MMP induce cell disassembly and migration. Only MMP-3 and -7 cleave cadherins and induce adhesion. MMP-3 deficient mice showed normal wound epithelialisation without contraction. Presumably by controlled proteolysis of intercellular molecules, cell adhesivity increases. Firm adhesion complexes provide stable anchorage sites for force generation. Selective MMP-3 inhibition would reduce contraction without impairing epithelialisation. The concept of the epithelial role in contraction differs from the paradigm and marks a beyond the state-of-art approach in wound healing. Keratinocytes at the air-liquid interphase close wounds by reepithelialisation and surface minimization. Hence, reduction of surface tension would decrease epidermal contraction. Alveolar surface tension is reduced by surfactants in preterm infants. Assuming that epidermal wounds could profit of surfactants is a high risk high gain approach of tackling hypertrophic scarring, but if successful it would revolutionize burn wound therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'FINGERprinting cold subduction and Plate Tectonics using key minerals', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Plate Tectonics (PT) is a well-established framework of moving plates made of oceanic and continental lithosphere. The main driving force of this system is the slab pull, a force imposed as the older and colder subducting plate sinks into the asthenosphere at convergent boundaries, producing Low Temperature/High Pressure (LT-HP) metamorphic rocks. Although our understanding about PT has improved in the last decades, there are major unknowns remaining, namely when and how its onset took place, a highly controversial topic. The record of LT-HP metamorphic rocks becomes continuous only from 850-750 Ma onwards, but recent evidence of these rocks at 2100-2000 Ma suggests a similar Tectonic regime operated at this time as well. An outstanding question arises: did Plate Tectonics, as we know it today, begin to operate only 850Ma ago or did this change take place much earlier but disappeared as the result of a preservation bias affecting LT/HP rocks? FINGER-PT will test this hypothesis using detrital minerals in sedimentary rocks that can track older LT-HP. Key minerals that can retain pressure, temperature, and age (P-T-t) information will be used, applying chronothermobarometric tools. Through a multidisciplinary approach, we will (i) combine the existing tools with new ones to obtain reliable P-T-t conditions; ii) test these tools and study the survival of eroded LT-HP terranes via mineral analyses in analogue modern sediments draining an exposed subduction zone; iii) identify and sample the most appropriate units, whose detrital minerals record the last 1000 to 4000 Ma, to trace the secular evolution of cold subduction. The emerging new tools from FINGER-PT, some that push current technological boundaries, will be widely applied by other petrologists. Establishing when mode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Political Economy of Youth Unemployment' (YOUTHUNEMPLOYMENT), addressing dissemination and exploitation.

assistant: **Impact**

In recent decades, global and European policy makers have been very slow in recognising youth unemployment and underemployment as a priority challenge requiring decisive policy responses. While an urgent concern at the global level, youth employment is not only an issue for developing countries: in recent decades, both developed countries and countries in transition have seen their labour markets incapable of integrating newcomers.Youth unemployment is nowadays a crucial issue in the EU policy agenda. Several policy instruments have been designed to improve the labour market integration of young people. Up to now, the situation of youth in employment has not substantially improved. At the European Union (EU) level, the biggest challenge is to significantly increase participation rates in employment so as to limit, as much as possible, the effects of an ageing population, and overcome the negative economic consequences of a declining European labour force from 2010 onwards.Moreover, these structural features of the unemployment in EU and Eastern Europe have been exacerbated by the recent recession following the international financial crisis. Many young people involved in temporary work will most likely loose their jobs due to the fact that labour market reforms have been implemented in most countries looking at flexibility side only (and not also at the security side).This poses several policy questions:1. How policy intervention might prevent some particularly weak young people to fall into long-term unemployment or temporary work experiences?2. Is the springboard effect of temporary work contracts universal or is it linked to particular contractual conditions, such as type and length?3. Which kind of labour active policy programmes or passive income support schemes sh