RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'How natural hand usage shapes behavior and intrinsic and task-evoked brain activity.' (HANDmade) under Horizon 2020.

assistant: **Objectives**

A seminal concept in modern neuroscience is the plasticity of the developing and adult brain that underpins the organismic ability to adapt to the ever-changing environment and internal states. Conversely, recent studies indicate that ongoing sensory input seems not crucial to modulate the overall level of brain activity, which instead it is strongly determined by its intrinsic fluctuations. These observations raise a fundamental question: what is coded in the intrinsic activity? This project tests the hypothesis that intrinsic activity represents and maintains an internal model of the environment built through the integration of information from visual and bodily inputs. The bodily inputs represent the physical and functional interaction that our body establishes with the external environment. In this framework, the hand has a special role, as it represents the primary means of interaction with the environment. Do behavior and mental activity change as a function of the effector we use to interact with the external environment? In virtual settings, I test the resilience of the internal model to extreme manipulations of the body by replacing the hand with everyday tools. The hypothesis is that prior representations constrain novel behaviors and plastic changes of both intrinsic and task-related brain activities. This prediction is also tested on samples of acquired amputees. These subjects represent an interesting model because the hand loss might reflect loss of sensory representations and less constrain on task-related brain activation. Throughout a combination of behavioral approaches, methods and techniques ranging from kinematics to functional neuroimaging (fMRI and MEG) and virtual reality, this project provides insights on how the synergic activity of body and en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Simulation-Based Imaging: A New Tool for Revolutionizing the Diagnosis and Treatment of Cardiovascular Disease'.

assistant: **Innovation**

The 3D, time-resolved blood flow measurement technique known as 4D Flow Magnetic Resonance Imaging (MRI) is highly valuable for research and can play a crucial role in cardiovascular disease (CVD) diagnosis and treatment planning. However, it is limited by the fundamental trade-off between resolution, image quality, and scan time since current 4D Flow MRI methods use compressed sensing or spatiotemporal acceleration to achieve only a spatial resolution of 1-3mm and temporal resolution of 25-100ms in a scan time of ~10 minutes. To overcome this challenge, simulation-based imaging (SBI) may provide a method to augment 4D flow MRI data by fitting computational fluid dynamics (CFD) simulation to low-resolution and noisy 4D Flow MRI data.The primary objective of SBI is to generate a high-resolution velocity field by optimizing the simulation to closely match the available data. This approach overcomes the aforementioned limitations of 4D Flow MRI, which often suffers from inherent errors in resolution and scan time, leading to both quantitative and qualitative discrepancies. By utilizing SBI, a more precise and comprehensive visualization of blood flow can be achieved.Therefore, the ultimate goal of this project is to develop a novel SBI method for MRI that will be used to address a wide range of cardiovascular (CVDs) such as heart attacks, strokes, and congenital heart defects; providing high-quality images of structure and function with ultra-high resolution and fast scan time. The long-term impact of the proposed SBI framework is expected to revolutionize clinical diagnosis and surgical decision-making leading to more effective treatments and improved outcomes for CVD patients.


**Keywords:** simulation-based imaging; 4D Flow MRI; blood flow; computational fluid dynamics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ireland and Late-Georgian British Imaginings of Belonging: With Particular Reference to William Wordsworth' (ILBIB), addressing dissemination and exploitation.

assistant: **Impact**

Belonging – a concept at the heart of which lies a yearning for home – has domestic, regional, national, and even cosmopolitan implications. It was a particularly important concept in late-Georgian Britain (c. 1780-1830), during which time socio-political instabilities fostered an inward-looking impetus, prompting Britons to ask what home meant and what attachment to home entailed. This project looks at Ireland’s place in late-Georgian British imaginings of national and intranational belonging. Various forms of art – verbal, visual, and aural – will be analysed to show how the story of belonging overflowed formal limitations and became strategically embodied in art. To provide a foundation from which to branch out into various writers, artists, ideas, contexts, and works of art – which are selected across national and gender boundaries – I shall focus on the English poet William Wordsworth (1770-1850). Whilst Wordsworth’s writings about Scotland, Wales, and Continental Europe have been explored, his relationship with Ireland has yet to be fully studied.This project contributes to recent scholarly work on British travellers in pre-Famine Ireland, as well as to studies of Romantic writers’ Irish experiences. Focusing on the theme of belonging, this project revisits the debates, in humanistic geography, about the processes of mediation and remediation in which ‘space’ is turned into ‘place’, or, in another theoretical framework, into lieux de mémoire. But the central theoretical concern is to tease out the complex ways in which the story of belonging was framed in various cultural media and the socio-political implications of various forms of 'strategic storytelling'.This project will redress the marginalisation of Ireland in English literary studies, which reflects an abi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Clean technology hydrogen peroxide generation', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The proposal addresses the use of a modern innovative electrochemical approach to solve the problem of zero-emission production of hydrogen peroxide. The method to be developed is based on the use of polymer fuel cell technology employing membranes and electro catalysts specifically developed for the production of hydrogen peroxide. The modular character of the equipment will ensure a more widespread use of peroxide as a benign oxidizing agent and the integration of its modular production into chemical manufacturing, bleaching and disinfections. The concept to be developed has not only direct environmental benefits (the by-product of its use as an oxidation reagent is water) but will reinforce the European position in modern chemical manufacturing and clean electrochemical technologies. The simultaneous production of a valuable chemical and of energy will represent an important advance in manufacturing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The contribution of magma-carbonate interactions in the upper crust to volcanic CO2 emissions: quantitative constraints from experimental petrology, isotope geochemistry and thermal modelling' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Mt. Etna and Popocatépetl, the most important subaerial sources of volcanic CO2 show evidence of interactions with the carbonate rocks forming their sedimentary basement. The present project aims at quantifying the contribution of magma-carbonate interactions in the upper continental crust to massive CO2 production in these volcanic areas. Carbonate assimilation will be investigated by hydrothermal experiments and thermal modelling. The experiments will be performed at magmatic conditions (pressures, temperatures and water contents). The comparison between experimental results and existing data on natural volcanic rocks will allow to assess the degree of magma-carbonate interaction and the ensuing CO2 production. Furthermore, CO2 degassing mechanisms will be experimentally investigated by studying the carbon isotopic fractionation between the magma and the fluid phase, with the final goal of interpreting the isotopic signature of volcanic gases. In conclusion, by this study we intend to define a petrological and geochemical tool to characterize carbonate assimilation occurring at a given volcanic centre to finally quantify its CO2 emissions. By the proposed project the applicant seeks a competence diversification in the volcanological, petrological, geochemical and experimental fields. The demanded host organisation is at the forefront of experimental petrology, thermodynamic and volcanic degassing modelling and therefore represents the most appropriate one to the project and to the applicant’s individual needs. Via the training, the candidate intends not only to attain a high-level of expertise with both experimental and analytical instruments, but also to definitely broaden her methodological approach to volcanology, by increasing her physical and chemical knowledge o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Overcoming Mechanically-Induced Resistance to Chemo-Immunotherapy in Pancreatic Cancer'.

assistant: **Concept**

Cancer progression is closely associated with generation of mechanical stresses that cause the compression of tumor vessels, drastically reducing delivery of drugs. My co-workers and I found that host cells and extracellular matrix in tumors generate these stresses. Furthermore, we identified the anti-hypertensive losartan to alleviate intratumoral stresses and decompress vessels, allowing drugs to enter the tumor. My colleagues tested losartan in pancreatic cancer patients and found improved responses to chemo-radiation. Nonetheless, losartan cannot alleviate all stresses, and my preliminary data indicate that they induce chemotherapy resistance (“mechanoresistance”). Thus, even though vessel decompression facilitates drugs entering the tumor, mechanoresistance renders cancer cells insensitive to drugs. Alleviating mechanoresistance is an urgent clinical need, but this mechanism has not been well studied and strategies to overcome it have not been developed successfully. To address this challenge, I will employ a mixture of cutting-edge bioengineering and biology methods to identify the intracellular mechanisms that promote mechanoresistance, using in vitro and mouse models of pancreatic cancer. I will then employ inhibitors/drugs of the identified mechanisms to overcome mechanoresistance in vitro and in vivo to determine if they increase the efficacy of chemotherapy. I will also confirm whether these drugs work more effectively with losartan or alone. Using the best performing regimen, I will assess the immunological effects and efficacy in combination with immunotherapy, which has yet to induce a benefit in pancreatic cancer trials. In parallel, in order to take this ground-breaking goal of improving pancreatic cancer therapy to the clinic, I will examine the existen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ANGuilliform robot with ELectric Sense' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The aim of the ANGELS project is to design and build a prototype of a reconfigurable Anguilliform swimming robot able to split into smaller agents (and vice-versa), each equipped with a bio-inspired electric sense" used both for recognition of objects and communication between agents. This mode of active perception, present in some fish, is based on the polarisation of certain regions of their body, so generating an electric field flowing through an electroreceptive skin. The robot will exploit both "mechanical re-configurability", by changing body topology, and a new concept of "electric re-configurability" that will allow the robots to self-adapt their perception to their environment by changing the location of emitters and receptors on the robot boundaries. The electric field generated around the robots can be considered as an "electric-body" shaped through electric reconfigurations. ANGELS will explore the range of abilities conferred by different mechanical and electric morphologies, from the shaping of the common electric body shared by the agents navigating in formation, to design of behavioural cooperative rules inspired by fish for improving multi-agent perception through emergent collective behaviours. Thus the intelligence encoded in the animals' morphology will be applied to the design of a new generation of Autonomous Underwater Vehicles able to adapt to their environment and suited to a wide spectrum of uses, in particular in situations where vision cannot be used. To achieve these goals, the ANGELS will form a multidisciplinary team combining the complementary expertise of biologists, roboticians, image-processing specialists and nuclear physicsits specialised in the design of particle detectors."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cytokine signaling in macrophages: beyond JAK-STAT' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Dysregulated macrophage function underlies many inflammatory diseases. Cytokines, small secreted signaling molecules with immune-modulatory functions, shape the macrophages phenotype, thereby affecting disease states. Puzzlingly, many cytokines with opposing functions, utilize highly similar JAK-STAT signaling cascades, leaving it unclear how cytokine-specific responses can occur.In my previous work, I studied enhancer activation in mouse macrophages from genetically different strains. By studying genetic variation, I found that transcription factor (TF) motifs crucial for enhancer activation can be identified. I further developed the bio-informatic tool MAGGIE to study TF motif mutations in different strains of mice, which subsequently enabled me to discover a novel TF important for enhancer activation by the cytokine interleukin-4. Based on my findings, I hypothesize that cytokines require specific, yet unidentified TFs that cooperate with JAK-STAT signaling to mount cytokine-specific effects. CYTOMAC aims to identify these cytokine-specific TFs downstream of JAK-STAT that direct appropriate cell responses. I will exploit the genetic variation across mouse strains and study enhancer activation in macrophages from these strains in response to different disease-related cytokines. Specifically, I will: (1) use genetic diversity between mouse strains to identify specific TFs regulating cytokine-specific responses; to then target these novel TFs in (2) mouse and (3) human macrophages and (4) translate my findings to human disease and inflammatory disease models.Inhibitors targeting JAK-STAT show high potential in clinically treating inflammatory diseases, including rheumatoid arthritis. However, as they affect generic pathways of many cytokines they come with considerable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Semantics-Based Machine Translation' in the context of a Horizon 2020 call.

assistant: **Objectives**

Most current machine translation systems are either rule-based or corpus-based. They typically take the semantics of a text only in so far into account as they are implicit in the underlying text corpora or dictionaries. This is also true for the recent neural machine translation systems, which - in comparison to standard phrase-based systems, tend to have the focus even more on fluency rather than adequacy. However, it has been pointed out that it is unlikely to be able to bring machine translation quality to the next level as long as the systems do not make better use of semantic knowledge. For example, according to Kevin Knight future machine translation systems should use information of the type ""who is doing what to whom and when"", i.e. involving the identification of the semantic roles of the items occurring in a sentence. To move forward in this direction, we propose to implement and evaluate three different approaches: The first approach is based on state of the art machine translation but considers word senses rather than words. That is, a word sense disambiguation system is used to identify the word senses in large parallel text corpora. Then, in analogy to standard word alignment, the word senses are aligned across languages, and the resulting multilingual sense dictionaries are used in conjunction with the word sense disambiguation systems for translating new texts. Our second approach uses role labeling for identifying the semantic roles of the words in a sentence. The roles are aligned across languages, and this information is then used to improve the translation process. The third approach is based on an algorithm which computes the semantic similarity between phrases. It considers the translation task as finding semantically similar phrases across lang
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Democracy Support Practice After the Third Wave: Adapting to Change?' under Horizon 2020.

assistant: **Concept**

Democracy Support Practice After the Third Wave: Adapting to Change? (DemSupPra) aims to assess the significance and impact of three recent developments on the practices of international election observation and assistance: (1) rapid technological change (new voting technologies and communication revolution); (2) ‘social learning’ by autocrats, which made assaults against democratic institutions including elections less visible (‘fake compliance’); and (3) the use of the ballot box to ‘backslide’ or advance illiberal democracy (‘majoritarianism’).  It asks how have these elements affected the two democracy support practices; and how have democracy supporters adapted to these developments?  In doing so, the project also sets out to answers the policy relevant question, whether election observation and assistance are still fit for purpose. It seeks to suggest ways in which the effectiveness and credibility of the two practices may be strengthened, especially at a time when democracy and democratic institutions, including elections, are facing a fresh wave of contestation. The project’s objectives are to: (1) contribute to the conceptual, theoretical and methodological innovation in studies of democracy support, in particular election observation and assistance; (2) explain the impact of the three ‘crises of democracy’ developments on the two practices; (3) improve cross-fertilisation between policy practice and academic research. These objectives will be achieved through a mixed-methods approach that combines: mapping of election observation and assistance as practices and a quantitative assessment of their adaptation to change (WP1); with qualitative comparative case study design to investigate the impact of the ‘crisis of democracy’ developments (WP2);  enriched by diss