RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Understanding how selection for body weight in mouse operates at the RNA level', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The aim of this project is to enhance our understanding of how genetic selection for body weight in mouse drives changes at the RNA level. This is a key point for quantitative genetics because a better knowledge of the genetic control of gene expression would imply a better prediction of changes in the regulatory networks and subsequently in the phenotype. Moreover, the biological insight gained by this understanding could, in turn, be used by the animal breeding industry to design more efficient breeding strategies. However, generally, genetic studies focus on understanding mean phenotypic differences among genotypes, although genes can also lead differences in the phenotypic variance between genotypes. Thus, this research will use a systems approach to model the genetic control of both, the mean and the variance of gene expression, and to identify regulatory networks than can be modified by selection. In addition, important environmental effects, such as maternal effects (e.g. uterine capacity), play an important role on the response to selection for growth in mammals. The second project aim is to elucidate how maternal effects shape the expression of genes and gain insight into the mechanisms underpinning gene by environment interactions. The recent emergence of high throughput technologies such as mRNA sequencing allows the study of the genetic and environmental makeup of cellular phenotypes. Furthermore, answering these questions require experimental designs and biological resources that are not usually available. The Roslin Institute has an extraordinary resource to carry out this research. After many generations of divergent selection for body weight multiple mouse lines were inbred, and kept inbred through brother-sister mating for over fifty generations. Four o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Lead potential of marine microorganisms from coastal, shelf and deep sea sediments, a comparative assessment for optimized search strategies' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Problems to be solvedThe objectives of this project for industrial, life science oriented marine product research are aiming at natural products as leads and/or enzymes, which are: target specific, aiming at defined classes of industrial life science effects, minimise unwanted side effects, relying on bio-sedimentary sources which are accessible, in a technical, economic and institutional sense, also for repeated re-sampling and re-supply, amount to products obtainable by cultivation or other bioengineering, and be obtained in sufficient quantities in a cost effective and environmental manner.Scientific objectives and approachSediments containing typical marine bacteria, known or expected to be producers of secondary metabolites from selected coastal, shelf and deep-sea areas of the North-East Atlantic and other open ocean regions are to be compared. Sedimentary-microbiological and symbiotic interactions, constituting factors of the sea floor in all water depth, are investigated and quantified. Sediment samples from an enclosed sea with oceanographic-environmental parameters different from the open ocean, the Mediterranean, and the eastern Mediterranean in particular, are special regional targets. Additional steps are cultivation experiments in the lab, isolation and pre-screening. Further tasks are the study of cultivation opportunities in the ocean, characterisation of bacteria and their secondary metabolites, structure elucidation, lead oriented multi-screening and bioassays. A general evaluation of responsible uses by life science industries and of existing and forthcoming rules and regulations will complement the research on the commercial and regulatory side. Application and adaptation of well-proven methods and necessary new developments of marine sampling and in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Bone from blood: Optimised isolation, characterisation and osteogenic induction of mesenchymal stem cells from umbilical cord blood', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

There is an urgent clinical requirement for appropriate bone substitutes that are able to replace current autologous and allogeneic grafting procedures for the repair of diseased or damaged skeletal tissues. Mesenchymal stem cells (MSCs), found predominantly in the bone marrow, are able to differentiate into osteogenic, chondrogenic, adipogenic and tenogenic lineages, thus offering considerable therapeutic potential for tissue engineering applications. However, invasive extraction procedures and insufficient viable cell yields have necessitated the identification of alternative tissue sources of MSCs. Growing evidence suggests that umbilical cord blood (UCB) contains a population of rare MSCs that are able to undergo multilineage differentiation.The aim of this proposal is optimise the isolation and expansion of MSCs from human UCB (CB-MSCs). The differentiation capacity of CB-MSCs will be examined, with a specific focus on osteogenesis. The CB-MSCs will be characterised by genomic, proteomic and bioimpedance profiling and compared to MSCs isolated from human bone marrow as well as embryonic stem cells. Full bioinformatics integration of datasets will identify specific and/or novel signalling factors associated with CB-MSCs. The immunophenotype and alloreactivity of CB-MSCs will be determined. Comparative analyses of the population doubling times, telomere length and telomerase activity will identify the lifespan of CB-MSCs. Novel expansion techniques will be combined with scale-up procedures and the generation of CB-MSC lines for banking using optimised cryopreservation protocols. In vitro and in vivo biocompatibility assays using a range of biomimetic scaffolds will be exploited, complementing in vivo homing and engraftment models. Our integrated approach using comple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Robust, Explainable Deep Networks in Computer Vision' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Deep learning approaches, mostly in the form of convolutional neural networks (CNNs), have taken the field of computer vision by storm. While the progress in recent years has been astounding, it would be dangerous to believe that important problems in computer vision are close to being solved. Many canonical deep networks for vision tasks ranging from image understanding to 3D reconstruction or motion estimation perform incredibly well ""on dataset"", i.e.~in the very setting in which they have been trained. The generalization to novel, related scenarios is still lacking, however. Moreover, large amounts of labeled data are required for training, which are not available in all potential application areas. In addition, the majority of deep networks in computer vision show deficiencies in terms of explainability. That is, the role of network components is often opaque and most deep networks in vision do not output reliable quantifications of the uncertainty of the prediction, limiting the comprehension by users. In this project, we aim to significantly advance deep networks in computer vision toward improved robustness and explainability. To that end, we will investigate structured network architectures, probabilistic methods, and hybrid generative/discriminative models, all with the goal of increasing robustness and gaining explainability. This is accompanied by research on how to assess robustness and aspects of explainability via appropriate datasets and metrics. While we aim to develop a toolbox that is as independent of specific tasks as possible, the work program is grounded in concrete vision problems to monitor progress. We specifically consider the challenges of 3D scene analysis from images and video, including tasks such as panoptic segmentation, 3D reconstruct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'PReparing for Optimal Phase III/IV maTErnal Group B StreptococCal vaccine Trials in Africa (PROTECT)'.

assistant: **Concept**

Two vaccines designed for pregnant women, to protect their unborn infant, are entering late phase development and will prevent infections from group B Streptococcus and respiratory syncytial virus, respectively. For these vaccines to be approved, the vaccine must work effectively without causing any unwanted responses. To implement these vaccines in countries with low resources, healthcare systems must be strengthened by improving vaccine safety monitoring and surveillance of infection, and advancing vaccine delivery, vaccine confidence, and patient participation.  The rapid rollout of electronic health records (EHR) in Kenya, Mozambique, Malawi, and Uganda offers an opportunity to use routine data to strengthen reporting of rates of adverse pregnancy, neonatal and infant outcomes, and any adverse events following immunisation; this will be imperative in informing and preparing for future large scale vaccination rollout campaigns. Our approach will address key gaps in EHR to develop pregnancy registries embedded within national reporting systems to establish this data, including baseline rates of pregnancy and infancy outcomes for Tetanus and COVID19 vaccines currently in use. These reporting systems will allow monitoring of potential safety signals once new vaccines are introduced. Experts in EHR, obstetrics and gynaecology, paediatrics, microbiology, clinical trials, and implementation research will develop the motivation and tools needed to monitor and evaluate current and future maternal vaccines.  We will work closely with the WHO, African Medicines Agency and Country Stakeholders, co-developing pregnancy registries, sentinel site microbiological surveillance systems, and maternal vaccination communications toolkits in preparation for the decade of maternal vaccine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SOLAR ASSISTED DESICCANT COOLING SYSTEM' in the context of a Fourth Framework call.

assistant: **Objectives**

In the project a new building climatization technique (dessicant cooling technique) is utilized for the climatization of a portugese office building. This technique allows the use of solar thermal energy for summer cooling as well as for winter heating. In the project this technology will be demonstrated and optimized operation and control strategies that fit well to the climate at the site will be developed. A monitoring program will yield information about system performance and allow to calculate saved energy, economic aspects and saved CO2-emissions.INNOVATIVE TECHNOLOGY : The new climatization system is driven with low temperature heat and replaces a conventional cooling/heating system driven by electricity and/or fossil fuels. The new technique, called dessicant cooling technique, is based on the process of evaporatic cooling; but the potential of evaporative cooling is distincly increased by using a dessicant material for the dehumidification of air. The system needs low temperature heat in the range of 50-60°C for the regeneration of the dessicant material. In the proposed project this regeneration step is done utilizing solar energy yielded from a solar collector field.CONTEXT OF OPERATIONS :Solar assisted dessicant cooling technique may be applied favourably for the climatization of buildings with high air circulation rates such as lecture rooms, restaurants, office buildings and similar.COST OF ENERGY :Estimated payback time presently is in the range of 20-30 years, but there is considerable potential of cost reductions.MONITORING : A monitoring program is an essential part of the project, since up to now there is nearly no experience about practical operation of solar assisted dessicant cooling systems in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Crystal-chemistry and reaction paths of kaolinite-smectite mixed-layer clays'.

assistant: **Innovation**

Mixed-layer clay minerals occur abundantly in soils and sediments, controlling their properties from mechanical stability to nutrient content. Recent discoveries in the field of mixed-layer clays, made by members of the host research group and the research group where I work, have opened new ways to study these minerals and revealed novel aspects. My project combines these two approaches in a detailed study of the mixed-layer mineral kaolinite-smectite. The main objectives of the project are 1) to fully characterize structurally and compositionally kaolinite-smectite, and 2) to use this information to assess the mechanism of smectite kaolinization. Natural kaolinite-smectite will be analysed using modern, complementary techniques, enhanced by tools of data analysis such as computer modelling.They include x-ray diffraction (composition, structure and particle size analysis), scanning electron microscopy (morphology of micro-crystals), high-resolution electron microscopy and microanalysis (chemical composition and structure of micro-crystals), thermal analysis, infrared spectroscopy (structure at atomic level). The evolution (composition, structure) along the kaolinite-smectite series will reveal the transformation mechanism. The results will contribute to a central problem in clay mineralogy, the nature of mixed-layering. Kaolinite-smectite is an ideal system for this study because it is composed of two members with great compositional and structural differences and will provide unambiguous results. Smectite kaolinization is a typical process of soil degradation and the understanding of its mechanism will help to assess soil degradation and soil sustainability, and to alter undesired trends. The project topic and techniques complement and deepen my previous experience, s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ecological modelling in biodiversity and ecological vulnerability' in the context of a Fifth Framework call.

assistant: **Objectives**

The host research group is composed of 22 modellers with many international co-operations. Thus the fellows will become acquainted with different modem and important branches of ecological modelling, and with a variety of ecological problems which can be modelled. They will learn a structured approach to constructing models which are tailored to the specific problem of interest and available information . This approach to problem solving will enable the fellows to identify a modelling approach that is appropriate for their own doctoral work. Fellows with a PhD theme in ecological modelling will learn both new techniques of ecological modelling (rule-based, individual-based, grid-based spatially explicit, stochastic, GIS-related), and methodologies for connecting their work to general ecological concepts and theories. Fellows who are primarily field ecologists will become familiar with evaluating the published modelling literature, to co-operate with other modellers and to construct small models of their own. Fellows will gain an appreciation of the potential applications of modelling to the own work, and how rule-based modelling can be applied to economic and sociological
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Destination Future' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

During the European Researchers Night researchers will leave their laboratories, take over St. Poelten, the capital city of Lower Austria and transform it into the “Destination Future”.While the successful Researches Night “F.I.T für Forschung” turned the campus of St. Poelten University of Applied Sciences into an intellectual fitness centre in 2011, the event will cover the whole city center in 2013 with loads of different activities taking place at several locations, such as the train station, the cinema paradiso, the state theatre, the city museum, the cathedral, the main square  and temporary disused salesrooms.Visitors of the European Researchers Night will be invited to join a journey through time, to betake themselves  into the future and to experience manifold future prospects. Scientists and researchers as well as designers and artists will present their visions of possible social, cultural, technical developments. Mainly interactive activities on the base of ongoing research projects in fields like information and communication technologies, health, human sciences, design, art  and archaeology ensure an exchange of ideas and experiences between researchers and the public.The main goal of the Researchers Night is to attract as large an audience as possible. It is crucial that researchers will meet all age groups, genders, as well as both rural and urban populations. Learning today is life long and international. All groups can provide the researchers of the future.The Researcher Night will follow a multi-disciplinary approach and will offer a diversified program for the mind, body and soul, which not only presents researchers and their ideas to the public but also gives the audience the chance to take an active role in some of the activities to experience the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Nexus: an experimental system to study marine larval dispersal' to be submitted under Horizon 2020.

assistant: **Abstract**

Dispersal is a fundamental trait for the ecological and evolutionary dynamics of any given species. In marine systems, the primary means of connectivity among fragmented habitats is pelagic larval dispersal (LD). Due to the inherent difficulty of tracking minute larvae in the ocean, we are still lacking critical insights into the internal and external causes and consequences of LD. Here, we propose the development of an experimental infrastructure, the Nexus, composed of 25 interconnected larval rearing/settlement tanks, designed to study larval movements as a model of dispersal. We aim to use the Nexus framework to investigate central questions in LD theory that, up to this point, have been difficult to assess: (1) Do marine organisms exhibit condition-dependent dispersal strategies? (2) If so, how does the interaction of phenotype and environment affect dispersal behaviours (context-dependence)? (3) How will climate change affect condition- and context-dependent dispersal in offspring via parental effects? These are timely issues to address, as a better understanding of the underlying mechanisms regulating LD will help predict species’ responses to rapid environmental change. The intended framework will facilitate the holistic assessment and controlled manipulation of the entire LD process, from the natal environment to post-settlement selection, thereby paving the way for novel research avenues in aquatic dispersal ecology. Each tank in the network can independently be controlled for the type of habitat it provides and corridors can flexibly be opened, closed or made directionally permeable. The versatility of the Nexus offers a high degree of experimental flexibility and control to address key issues in spatial meta-population ecology.