RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Optical characterisation methods for mems manufacturing (OCMMM)' (OCMMM).

assistant: **Innovation**

While testing electrical properties in microsystems is a well-developed art the testing of mechanical properties of MicroElectroMechanical Systems (MEMS) is not. However, the micromechanical characterisation plays a crucial role, both during design and development of microstructures and during chip-production, assemblage and life cycles of the finished MEMS products.Two different optical approaches are proposed to improve the MEMS testability, based on:i) on-chip integrated techniques and;ii) external full-field interferomety. The qualification and validation of proposed testability procedure is made by industrial driven demonstrations and application examples (data storage, microsensors for avionics). The OCMM proposal represents the European module of a world-wide cluster that is going to co-operate within an IMS action, where an interdisciplinary and industry-led consortium has been formed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European summer school in cultural studies' under Sixth Framework.

assistant: **Concept**

The European Summer School in Cultural Studies offers to organise research training based on new research agendas in the field of cultural studies on a European scale. With the European Summer School in Cultural Studies we wish to supply an international forum for the development of cultural studies with a focus on new research methodologies and research organisation in this trans-disciplinary landscape.The relevance for such a forum stems from four needs:­The need for a profiled European platform for the development and dissemination of the important, but fragmented research effort in cultural studies­The need to train doctoral candidates with background in the humanities in trans-disciplinary problems and methods in order to equip them to meet the new challenges arising in their respective fields of specialisation through the paradigm of cultural studies­The need to enter into a dialogue with the contemporary art practices where new strategies for manoeuvring in a changing cultural landscape are developed­The need to build effective and sustainable networks in this new field of research for doctoral students.The ESSCS will contribute to the strengthening of European doctoral training in cultural studies through synergy between advanced research environments at the partner institutions. The European collaboration within the framework of the ESSCS will create a platform for innovation and systematic sharing of knowledge among graduate schools in cultural studies, including mutual recognition of qualifications and unproblematic transfer of credits between the institutions and explicit incentives to enhance structures and agendas for research and teaching at the individual institutions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'LivingKnowledge – Facts, Opinions and Bias in Time', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Knowledge and its articulations are strongly influenced by diversity in, e.g., cultural backgrounds, schools of thought, geographical contexts. Judgements, assessments and opinions, which play a crucial role in many areas of democratic societies, including politics and economics, reflect this diversity in perspective and goals. For the information on the Web (including, e.g., news and blogs) diversity - implied by the ever increasing multitude of information providers - is the reason for diverging viewpoints and conflicts. Time and evolution add a further dimension making diversity an intrinsic and unavoidable property of knowledge.<br/>The vision inspiring LivingKnowledge is to consider diversity an asset and to make it traceable, understandable and exploitable, with the goal to improve navigation and search in very large multimodal datasets (e.g., the Web itself). LivingKnowledge will study the effect of diversity and time on opinions and bias, a topic with high potential for social and economic exploitation. We envisage a future where search and navigation tools (e.g., search engines) will automatically classify and organize opinions and bias (about, e.g., global warming or the Olympic games in China) and, therefore, will produce  more insightful, better organized, easier-to-understand output.<br/>LivingKnowledge employs interdisciplinary competences from, e.g., philosophy of science, cognitive science, library science and semiotics. The proposed solution is based on the foundational notions of context and its ability to localize meaning, and the notion of facet, as from library science, and its ability to organize knowledge as a set of interoperable components (i.e., facets). The project will construct a very large testbed, integrating many years of Web history and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Synaptic Systems: dissecting brain function in health and disease' (SYNSYS), addressing dissemination and exploitation.

assistant: **Impact**

Major disorders of the Central Nervous System (CNS) affect one in three people in the developed world, often seriously disable the affected individual, and together account for the single largest burden on the healthcare systems of the EU. Most of these disorders act at the neuronal synapse, a cellular organelle comprising in the order of 2000 proteins. Pleiotropy, cross-talk between proteins and the complexity of the underlying signalling complexes pose a significant challenge to dissecting the molecular mechanisms of disease and to design efficient drugs. SynSys assembles leading European laboratories to provide the expertise and established research platforms that uniquely enable a systems-level analysis of synaptic signalling. The consortium features a closed loop from data integration and modelling, human genetics, physiology, proteomics and the application of engineered model systems to test model predictions. The main objectives of this project are to (i) provide a qualitative and quantitative description of the protein composition and the interactome of the mammalian glutamatergic synapse that integrates known human variation in these genes, (ii) to generate quantitative dynamic models describing the main functional features of the synaptic system, (iii) to reiterate on modeling by relating model predictions to synaptic function, (iv) to identify and validate, using appropriate model systems, human vulnerability genes that may form the basis of future therapies. Only a Systems level analysis can provide the means to describe synaptic transmission from molecule to function, its dynamics in relation to physiology and, brain function and brain disorders. As such, SynSys will establish a new platform for iterative molecular analysis of synapse function and dynamic m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'XVI Polish Peptide Symposium' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The conference planned for ca. 200 participants from various countries, is held every second year and organized by various universities in Poland. The aim of the meeting is to discuss the present achievements in peptide research and their potential application in pharmacology/medicine (peptidergic drugs), chemistry (synthesis including combinatorial synthesis, conformational studies, structure-activity-relationships) and physiology (new functions in drug addiction, pain and neurodegenerative disorders (Alzheimer, Parkinson). Preliminary topics include: Workshop: Biomolecules - identification and function" Methodology for peptide synthesis Biological action of synthetic peptides Function of the endogenous peptides Round table discussion "Future perspectives of peptides" Poster sessions The official conference language will be English, and the meeting is organized under patronate of the Rectors of the Jagiellonian University. Our intention is to promote this meeting among younger scientists (ca. 50% of participants). An opportunity to have a direct contact with internationally recognized scientists and discussions in English gives a perfect chance for young researchers. The conference will have, for the first time, an interdisciplinary profile, gathering together chemists, biochemists, physicists, immunologists and pharmacologists.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00048-1.pdf"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Animal health biosafety research centre cisa-inia'.

assistant: **Objectives**

Description:CISA-INIA is the most modern and functional world-wide conception of a Biosafety Research Centre to work in vitro" and "in vivo" in animal research on high risk and exotic infectious diseases as well as for studies on environmental health. The size and the quality of its infrastructure are pretty unique in the world where only 7 Biosafety large laboratories on Animal Health have similar characteristics. The High containment area covers 10,824 m2 with 26 laboratories and 14 common use rooms of Biosafety level 3 (BSL-3), including tissue culture rooms, imaging treatment, isotopes laboratory, photographic treatment, histology and pathology laboratories and electron microscopy . The animal facilities are composed of 21 individual, multi-species and polyvalent rooms with the potential to shelter from fishes to large animals as cattle and horses. The Environmental toxicology facilities cover an area of 923 m2 and are composed of 10 BSL-2 laboratories, animal facilities and auxiliary areas.Application:On February 2002 a website exclusively dedicated to the project will be available at www.ahbiosafety-cisa.ws , in which all the details of how to apply for access are described including the forms required to fill up the Proposal of Access. In addition an electronic email address for getting information about the programme is already available at info@ahbiosafety-cisa.ws."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The 3D Galaxy' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The main objective of the proposal is the investigation of the Galactic interstellar medium (ISM) and, especially, of its constituents. This study is motivated by the fact that the ISM is the site in which matter in the Galaxy collapses into stars and is then rejected at the end of their life therefore providing a unique source of information for tracing the complete evolution from dust to stars and from these to the final supernova phase. The project , in particular, aims at the 3D reconstruction of the spatial distribution of the three thermal phases of the ISM gas (namely, molecular, neutral and ionised). This goal will be achieved by using an inversion method and such application will be innovative for the unprecedented consistent implementation of the ionised phase of the gas. This action will be performed in two steps: first by including HII regions (localized sources of ionised gas in the Galaxy) through the exploitation of velocity data which are available for a relevant number of these sources; then by implementing the diffuse ionised component thanks to the kinematics information encoded in recently obtained HII recombination lines data. The ionised gas component, which is currently the least known among the ISM gas phases, will be the subject of the second part of scientific analysis. Since one of the most puzzling questions concerns its detection in regions far from sites of star formation where ultraviolet radiation is expected to be, a new approach to this problem will be attempted, based on the observed correlation between dust and ionised gas. These two components of the ISM have been found to correlate on large angular scales but studies conducted on the scale of individual regions of stars formation seem to indicate that the correlation breaks down on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Quorum sensing as a tool to detect and target pro-oncogenic microbial biofilms associated with right-sided colorectal cancer' (BIFCOLC-QS) under Horizon Europe.

assistant: **Objectives**

Colorectal cancer (CRC) development and progression have been linked to the presence of pro-oncogenic bacterial strains in the intestine, such as Fusobacterium nucleatum, pks+ Escherichia coli and enterotoxigenic Bacteroides fragilis. These pathogenic bacteria produce toxins that can disrupt gut epithelial integrity resulting in heightened pro-inflammatory response, enhanced DNA mutations, and increased cell proliferation, which can eventually lead to adenoma formation. In addition, these bacterial pathogens show increased genotoxicity by forming invasive polymicrobial biofilms, thereby resulting in CRC development. Recently it has been reported that anatomical location plays a crucial role in CRC development, progression, microbial colonization, response to therapies and disease outcome. Indeed, right-sided CRC is generally associated with pro-oncogenic bacterial biofilms and is known to have an overall worse prognosis compared to left-sided CRC. Pathogenic bacteria use quorum sensing (QS) machinery in the gut for their communication, which is essential for biofilm formation. We aim to develop an intervention strategy employing QS machinery to engineer a probiotic bacterial strain with sensing and killing properties to detect and target these pro-oncogenic polymicrobial biofilms. The sensor device will detect autoinducers produced by pathogenic bacteria on encountering their biofilms, activating the killing device. The killing device expresses a biofilm degrading enzyme, Dispersin B, which will disrupt these biofilms and eventually kill the pathogenic bacteria residing in these biofilms by the type VI secretion system. These polymicrobial biofilms can act as a marker of CRC and help to understand the role of CRC-associated pathogenic bacteria in CRC development, which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'BOOSTING COLLABORATION BETWEEN RESEARCH CENTRES AND INDUSTRY TO ENHANCE RAPID INDUSTRIAL UPTAKE OF INNOVATIVE FUNCTIONAL TEXTILE STRUCTURES AND TEXTILE RELATED MATERIALS IN A MONDIAL MARKET' in the context of a Seventh Framework call.

assistant: **Objectives**

2BFUNTEX will exploit the untapped potential in functional textile structures and textile related materials. It will bring together all innovation actors in the field fostering a multidisciplinary approach between universities, research institutes, SMEs (in textile 95% of the companies are SMEs) and sector associations. The 2BFUNTEX team will identify technological gaps and will eliminate barriers resulting in a faster industrial uptake of added value functional materials with new functionalities and improved performance and resulting in creation of new business worldwide.Technological needs will be mapped, new joint international research disciplines will be identified and multi¬disciplinary lab teams will be created between universities, research institutes and SME research departments. International cooperation will be favoured to exploit the worldwide market expansion potential. Industry will be involved at all stages of the process and will be able to adapt production methods, management and distribution in an early stage. The inventory will enlarge the team of important textile universities and renowned materials research centres and will identify new collaborations. Synergy will be reinforced and created which will enable to identify and develop new functional materials.Training material for research and industry purposes regarding functional materials will be elaborated and implemented European and worldwide. This material will be designed also for sector organisations to train technical people in their SMEs. It will allow a common language regarding functional textile structures and textile related materials, and will increase the number of well-trained people in this field.2BFUNTEX will organise and participate in conferences, workshops and brokerage events. A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'MUlti-Industry, Semantic-based Next Generation Business INtelliGence'.

assistant: **Innovation**

MUSING aims at developing a new generation of Business Intelligence (BI) tools and modules founded on semantic-based knowledge and content systems. MUSING will integrate Semantic Web and Human Language technologies and combine declarative rule-based methods and statistical approaches for enhancing the technological foundations of knowledge acquisition and reasoning in BI applications. The breakthrough impact of MUSING on semantic-based BI will be measured in three strategic, vertical domains: * Finance, through development and validation of next generation (Basel II and beyond) semantic-based BI solutions, with particular reference to Credit Risk Management *  Internationalisation, through development and validation of next generation semantic-based internationalisation platforms *  Operational Risk Management, through development and validation of semantic-driven knowledge systems for measurement and mitigation tools, with particular reference to IT operational risks faced by IT-intensive organisations.  Main S&T objectives: 1. Development of a self-adapting BI system that integrates and specialises high-level semantic technologies for supporting next level of effectiveness in operations in different industries 2. Combined use of declarative rule-based approaches and statistical methods in the semantic technology 3. Validation of RTD results in three high-social-impact, vertical domains 4. Modelling and recognising evolving knowledge accounting for temporal logic 5. Support to development of innovative technologies that enable enterprises' self-assessment.  Prime tangible results: 1. A set of innovative knowledge management components to be utilised in multi-industry contexts 2. An integrated, self-adapting framework to develop specialised BI applications for vertical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A heart valve prosthesis and delivery system intended to replace damaged tricuspid valves and prevent right ventricle dysfunction', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

About 17 million people die each year from cardiovascular diseases (CVDs), a number that is expected to grow to more than 23 million by 2030. Of these deaths, an estimated 7.4 million were due to heart disease, including heart valve disease (HVD) such as tricuspid regurgitation (TR). The golden standard methods for tricuspid valve diseases are standard open-heart surgery and transcatheter valve replacement. However, high-risk interventions require long recovery time long in-hospital stays and have significant hospital mortality (more than 10%). Transcatheter tricuspid valve replacement (TTVR) is still ineffective due to the increased risk of side effects in right ventricle making this solution not available on the market. TriSol is introducing the TriSol System, a heart valve replacement system for treating severe TR and preventing RV dysfunction which usually follows tricuspid valve surgery. A flexible delivery system allows to position the valve into the heart through support arms for anchoring to the tricuspid physiological site. The entire procedure is performed in a medical center and takes up to 30 minutes compared to 2-4 hours of standard surgery. Trisol System will allow cardiologists to perform a quick and safe implant procedure thus increasing the number of treated population and reducing in-hospital and recovery time. Moreover, it will increase heart performance and reduce the risk of mortality typical of open-heart surgeries. During the feasibility assessment, a go-to-market strategy and a supply chain will be established, as well as further development plan will be drafted.  During the second phase of innovation project, TriSol will upgrade the valve and delivery system components of TriSol system for application in multiple valve conditions such as mitral