RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European Research Infrastructures in the International Landscape' (RISCAPE).

assistant: **Innovation**

RISCAPE will provide systematic, focused, high quality, comprehensive, consistent and peer-reviewed international landscape analysis report on the position and complementarities of the major European research infrastructures in the international research infrastructure landscape. To achieve this, RISCAPE will establish a close links with a stakeholder panel representing the main user groups of the report, including representatives from ESFRI, the OECD and Member state funding agencies to ensure usability and the focus of the Report. It will also benefit from close co-operation with other projects and initiatives in the European research infrastructures development to ensure consistency with the existing landscape work. Particularly, RISCAPE builds on the European Research Infrastructures (RIs) in the ESFRI landscape report (2016) and on the landscape analysis done or currently underway in the H2020 cluster projects. RISCAPE leverages the experts on the European RIs with extensive knowledge on the disciplines involved and RI development in Europe and the  project benefits from the contacts and tools developed in the cluster- and international RI collaboration projects to maximize the discipline-specific usability of the results. A key factor in the RISCAPE analysis is that the complementarities will be analyzed in a way which is natural and suitable for the discipline and RI in question. The resulting Report and the used methods will be independently peer reviewed to maximize the usability and objectivity of the information provided for the EU strategic RI development and policy. The project answers directly to the European Commission strategy on EU international cooperation in research and innovation, particularly on the need to obtain objective information in order to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Enabling Cost-effective Process Simulation for the Composites Industry: Efficient Characterisation of Complex Fibre Preforms'.

assistant: **Concept**

Composite materials offer significant benefits over traditional engineering materials, combining low mass with increased stiffness and strength, making composite materials a very attractive option for engineers and manufacturers. However, commonly applied manufacturing techniques have been labour and skill intensive. This has significantly increased the usage of a range of processes known as liquid composite moulding (LCM), involving injection of resin into a compressed fibre reinforcement, capable of high-volume, high-quality production.  Simulation of LCM processes offers significant advantages in process design, cycle time and setup cost reduction, however the practicality of existing simulation software is limited by the considerable time and resources required to obtain the necessary material data input.The overall aim of the proposed project is to develop efficient techniques to characterise the permeability and compaction response of fibre reinforcements. These are the dominant material properties governing LCM processes, representing a material’s resistance to fluid flow and resistance to being compressed. Efficient characterisation techniques will benefit Europe through enabling cost-effective process simulation for the composites industry.A number of work packages will be required to meet the project aim. Firstly: development of permeability and compaction measurement facilities at the Institute for Carbon Composites at TUM. These facilities will be used to conduct studies on fabric reinforcements to determine the dominant material parameters affecting permeability and compaction response.  Significant consultation will take place to determine the requirements of a range of sectors within the European composites industry, assessing industrial requirements in r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Enhancing the Innovation Management Capacity of Cypriot SMEs in the Enterprise Europe Network - KAM2CY' (KAM2CY), addressing dissemination and exploitation.

assistant: **Impact**

The Research Promotion Foundation (RPF) is submitting the Proposal entitled “Enhancing the innovation management capacities of Cypriot SMEs in the Enterprise Europe Network”. Founded in 1996, the RPF was established at the initiative of the Government of the Republic of Cyprus, to promote the development of scientific, technological research and innovation in Cyprus. The Foundation is an independent organisation and its main objectives include: The design, launching and monitoring of National Research and Innovation Funding Programmes and also the promotion of the participation of Cypriot entities and researchers in European Research and Innovation Programmes. The RPF has the overall responsibility for the coordination of activities relating to the Horizon 2020. The RPF is the Coordinator of the Cyprus Business Support Centre (BSC-Cy) and responsible for the implementation of the innovation, technology and knowledge transfer activities and provides information and support for the participation of BSC-Cy clients in the national and european research and innovation programmes.The general objective of the project is to contribute to smart growth in the European Union and specifically in Cyprus by contributing to a better and more efficient connection of participants along the innovation chain. The RPF will deliver its specially designed services by assisting the local SMEs in the area of innovation management. These services will be provided to two specific groups: (a) Beneficiaries of the SME Instrument, and (b) SMEs with significant innovation activities and high potential for internationalizationSeven days’ service packages will be designed and delivered by consensus between innovation experts as additional support services of the BSC-Cy targeting the two abovementioned
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'FUNCTIONAL PROPERTIES OF THE SUPERIOR TEMPORAL POLYSENSORY AREA AND THEIR ROLE IN THE MIRROR SYSTEM""' under Sixth Framework.

assistant: **Concept**

The present application aims at obtaining a fellowship for a young French researcher, permitting him to carry out a post-doctoral stage. The host laboratory is the Institute of human physiology, located in Parma (Italy) and directed by Pr Rizzolatti. After a preliminary conversation, Pr Rizzolatti has proposed to the candidate Ludovic Escola to participate in a large project concerning the mirror system", a brain function supposed to be implicated in action understanding. The part the candidate will have to deal with is an electrophysiological study of the properties of the superior temporal polysensory area (STP) of the monkey, and their relation with the "mirror system". Ludovic Escola seems to be a good candidate for this work since he has acquired during his doctoral formation a solid background in electrophysiological investigations in the monkeys of different aspects of motricity. Moreover, this stage offers him the opportunity to learn recent techniques such as multi-unit recordings of neuronal activity and echography, which he will then be able to develop in the laboratory he comes from. So this experience is certainly a real gain for his future career as a researcher. A last profit, but not least, is the possible construction of collaboration between two European laboratories working each on differentaspects of motricity, thus strengthening the European scientific Community."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Developing Latin American fruits usin the yeast KLUYVEROMYCES MARXI ANUS and its pectinolytic enzyme endopolygalacturonase' (1994-1998).

assistant: **Concept**

The main objectives are as follows :* To produce strains of Kluyveromyces marxianus that over-express the endopolygalacturonase (endo-PG) gene.* To study and optimise cocoa fermentations using these strains.* To produce the enzyme endo-PG from these strains.* To study and optimise processing qualities of indigenous Latin American fruits using the endo-PG enzyme.* To isolate yeasts from indigenous fruits with superior enzyme and fermentation characteristics.Expected OutcomeThe work carried out should enable existing cocoa fermentations to be optimised which will lead to the production of chocolate of more reliable and improved quality. Some under-exploited Latin American fruits will be developed and be brought to market initially as fruit juices. An enhanced range of microbiological strains will be both created and characterised for use in these and other fruit fermentation industries. A new and independent source of pectinase will be developed for food use on Latin American fruits.The key activities envisaged are :* Create endo-PG overproducer strains of K. marxianus by conventional means. Use these yeast strains to produce stable, dried yeast for use in cocoa fermentations on the farm. Clone and sequence the endo-PG gene and then overproduce the enzyme using genetic modification techniques for large-scale production purposes.* Use both wet and dried modified yeast strains to study altered cocoa fermentations both in laboratory-scale experimental fermenters and in small-scale field trials and determine the physiological parameters to optimise the fermentation.* Develop a production protocol that integrates, in one step, fermentation and purification using the genetically modified K. marxianus yeast strains for bulk enzyme production. Scale-up to produce food-grade, part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enzyme-Linked DNA Displacement (ELIDIS) Assay as an innovative immunoassay platform', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Since its introduction more than 50 years ago, ELISA (Enzyme-Linked Immunosorbent Assay) remains one of the most widely used technologies for research, drug discovery and diagnosis. The reasons for this extraordinary longevity are manifold: ELISA combines the high specificity of antibody-antigen interactions with the high sensitivity of enzyme amplification. However, ELISA also has disadvantages: multiple washing steps and reagents are required and a specialized instrument is needed, which is not always available in all laboratories. An innovative immunoassay technology that can overcome the limitations of ELISA while retaining all of its best features would therefore represent a turning point in the global immunoassay market (> $35 billion in 2023).Under the ERC Consolidator Grant PRO-TOOLKITS, we have developed a novel immunoassay, which we have named Enzyme-Linked DNA Displacement (ELIDIS), which has all the characteristics to meet this need and become an alternative to ELISA. In short, ELIDIS involves 2 steps and is based on the use of enzyme-conjugated DNA strands and disposable electrodes. ELIDIS retains the advantageous properties of ELISA (high sensitivity and specificity) but, unlike ELISA, is easier to perform, does not require enzyme-labeled antibodies and, more importantly, can be performed using portable electronic devices such as a laptop or smartphone without the need for additional instruments.With these considerations in mind, in this PoC project we will validate the ELIDIS assay as a candidate to replace ELISA in any biotech and biopharma laboratory. To achieve the above goal, we will: 1) Validate the ELIDIS assay for the detection of two model targets (Trastuzumab and EGFR); 2) Develop two prototype kits using disposable sensor arrays and a portable d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Doctoral Industrial School on Human Skin models for Staphylococcal infections'.

assistant: **Innovation**

Staphylococcus aureus (S. aureus) is a major human pathogen and cutaneous infections are among the leading cause of emergency department visits. Unfortunately, S. aureus vaccine development is hindered by the lack of known correlates of protection. Three dimensional organotypic human skin models may represent a valid alternative to animal infection model.Indeed, S. aureus expresses several human-specific virulence factors. However, at the present such models have been rarely used in the S. aureus research field and, to our knowledge, never with immune-competent models. Therefore, a major aim of this proposal is to develop a human skin equivalent and integrate key immune components in the epithelial matrix. To accomplish this goal we will take advantage of cutting-edge technologies, such as induced pluripotent stem cells to generate macrophages and neutrophils. The model will be used and optimized to the following main objectives: better understanding of human-specific pathogenesis of S. aureus as well as protective mechanisms against the pathogen; development of the first immune-competent human skin models for vaccine research; determine the role of bacterial communities on skin infections; provide alternative methods to animal models. The proposed scientific program will be complemented with a number of training courses based on specific skills for which both the University of Utrecht and Novartis Vaccines are renowned. Complementary courses on dermatology, human skin infections, hydrogel scaffolds, mass spectrometry, and induced pluripotent stem technology, will be held by associate partners. At the end of the project the students will receive a PhD degree in the area of Infection and Immunity. We believe that this project is at the leading edge of science and technol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A TRIP through chromatin and DNA double strand break repair' (TRIP).

assistant: **Concept**

Genes tend to aggregate, nucleotide usage tends to change over large domains and yet, reasons for this are poorly understood. This suggests that there exists unknown molecular processes at work  for millions of years and that shape the structure of modern genomes. Understanding the organization of genomes is another way to look into these molecular processes. Particularly relevant are DNA repair and chromatin processes, which can have a significant impact on the global organization of a genome. In this project, we hammer out the concept of chromatin print; which represents the effect of the local chromatin structure on the evolution of genomes through DNA repair. The existence of the chromatin print is no longer to be established, but the nature and strength of the phenomenon escape experimentation for lack of appropriate technologies. We are developing a method called TRIP for Thousands of Reporters In Parallel to precisely tackle this issue. The goal of this project is to develop and use TRIP to obtain a genome-wide dataset revealing how double-strand breaks occur and are repaired in different chromatin environments. This will give a clearer picture of the evolution of regulatory sequences and of the strength of the chromatin print. In the long term, knowledge of mutation-prone sequences might be used for routine prenatal checks of human syndromes caused by de novo mutations such as autism.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Atom Probe Tomography (APT) Metrology for future 3D semiconductor devices' (APT) targeting Horizon 2020.

assistant: **Abstract**

This proposal presents a training-by-research plan in the emerging and exciting field of Atom Probe Tomography (APT) and its application in analysing non planar atomic scale state-of-the art semiconductor nanostructures.  Central to this project are the metrology and training advances needed to underpin the next generation of 3 dimensional (3D) device architectures based on atomically engineered materials and interfaces (e.g. FinFETs such as the Tri-gate transistor ). Amongst the possible emerging 3D analysis techniques which meet industrial requirements in terms of 3D-spatial resolution is APT. However, within the semiconductor field APT as a characterisation tool is still in its infancy with many challenges unresolved from both a fundamental understanding perspective as well operational performance.  It therefore remains prone to many artefacts and limitations such that one has not yet reached the robust analysis levels required for the semiconductor industry - i.e. qualitative versus quantitative information, high success yield, tight reproducibility and accuracy, and a full understanding of the data quality. Research on the exploitation of APT for advanced semiconductor devices is restricted as it requires simultaneous access to an (expensive) APT tool and advanced semiconductor technology. Thus, the number of trained researchers is limited. This project therefore aims to: (1) advance the APT technique and (2) complement the applicant’s expertise with substantial training and knowledge of the APT technique. Through detailed investigations into the phenomena most impacting on APT new insights which will feed into the needs of the semiconductor industry will be sought. The research and training activities are designed to enhance the future career of the applicant by b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exascale Compound Activity Prediction Engine' under Horizon 2020.

assistant: **Concept**

Scalable machine learning of complex models on extreme data will be an important industrial application of exascale computers. In this project, we take the example of predicting compound bioactivity for the pharmaceutical industry, an important sector for Europe for employment, income, and solving the problems of an ageing society. Small scale approaches to machine learning have already been trialed and show great promise to reduce empirical testing costs by acting as a virtual screen to filter out tests unlikely to work. However, it is not yet possible to use all available data to make the best possible models, as algorithms (and their implementations) capable of learning the best models do not scale to such sizes and heterogeneity of input data. There are also further challenges including imbalanced data, confidence estimation, data standards model quality and feature diversity.The ExCAPE project aims to solve these problems by producing state of the art scalable algorithms and implementations thereof suitable for running on future Exascale machines. These approaches will scale programs for complex pharmaceutical workloads to input data sets at industry scale. The programs will be targeted at exascale platforms by using a mix of HPC programming techniques, advanced platform simulation for tuning and and suitable accelerators.