RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Researcher's night in the APULIAn sites of cultural interest' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

The European Researcher's night ARES will be organized by the Apulia Region, with the support of ARTI - the Regional Agency for the Technology and the Innovation - and the Apulian Universities. It will be animated by games, interactive activities and scientific experiments. The manifestation will be opened to the public at large and will demonstrate the importance of the scientific job for the progress of the society.The initiative addresses in particular way young people, encouraging them, in such an occasion, to consider the research like a possible profession and Europe like a dynamic place where to study and work. The night will be animated by different attractions organized in all the regional territory and connected in a virtual way through web TV. The activities will be carried out in different laboratories and departments of the five regional Universities and in some sites of cultural interest.The planned activities can be summarised in two categories:- activities aiming at the scientific spreading, as - simultaneous guided tours/visits in the university laboratories and sites in the region (Open Labs); - pro-active and hands-on experiments in the laboratories of the five universities (S&T demonstrations);- entertainment activities, covering different topics such as theatre, cinema and music related to science, in order to amuse people's interest and make the event strongly attractive (entertainment events).Both typology of activities will likely satisfy different age targets, from children to adults, not forgetting teen-agers. In order to support the regional innovation system, a specific promotion of the Human Mobility programme will be manage within the ARES APULIA project.More effort will be devoted in defining and promoting a permanent result aimed to favou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Multipartite Entanglement in Quantum Optical Systems' (ENTANGLQOPT).

assistant: **Innovation**

As one of the most interesting part of quantum optics and quantum information, I chose to study multi-partite entanglement. While bipartite entanglement is well understood, multi-partite entanglement is still under intensive research. Beside the point of v iew of theory, this topic is also very important from the point of view of experiments since with the rapid development of quantum control it is now possible to study experimentally the entanglement of many qubits using photons, trapped ions, or cold atom s on an optical lattice.In detail, I propose to study the following timely topics:(i) During the mobility period, I have developed several methods for detecting entanglement in optical lattices of cold two-state atoms. I would like to discuss further my fi ndings with experimentalists and look for a possible experimental realization.(ii) I plan to continue my work on characterizing the entanglement arising in spin chains. In a recent work I proposed to use energy for detecting entanglement in systems in ther mal equilibrium. This approach is very useful also from the point of view of solid state physics, since it gives further insight on the thermal ground state of familiar spin models.(iii) I would like to do further research on entanglement witnesses, or ent anglement criteria, in general, independent from direct connections to experiments. (iv) Finally, I would like to determine in what sense genuine multi-party entangled states are different from many-qubit states with partial entanglement. Are there quantum information processing tasks which need exclusively genuine multi-party entanglement? The answers to these questions would help considerably understanding multi-partite entanglement and would also point to new applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Climate Security with Local Authorities (CLISEL)  From insecurity takers to security makers: mobilizing local authorities to secure the EU against the impacts of climate change in Third Countries' under Horizon 2020.

assistant: **Concept**

CLISEL proposes an innovative approach to the question of how Europe can be secured from the impacts of climate change in Third Countries. Most academic and policy initiatives to date have focused on the direct security impacts of climate change in Third Countries and/or on the indirect impacts on international security (e.g. concerning regional economic or political stability). While those initiatives offer invaluable insights, CLISEL is based on the presumption that many indirect impacts on Europe’s security emerge and are felt at the local scale, within Europe itself. This is overlooked by most existing initiatives on the so called climate-security nexus, and the conditions under which local authorities act upon climate change (in)security within their operations are not well understood. To fill this gap, CLISEL explores the climate-security nexus from the perspective of local administrations and communities, based on the idea that innovations in the exercise of regulatory power of local authorities can contribute to enhance the understanding of the indirect security implications of climate change in Third countries, as well as to take proactive action. In particular, CLISEL looks at the issue of climate-induced migration, an issue often cited as an indirect security dimension of climate change, from the perspective of local administrators in Sardinia. The aim is to understand the extent to which migrants from ecologically vulnerable Third Countries are perceived as a security issue, the reasons why that is (not) the case, as well as the policies and actions through which local administrators can ward off the emergence of security crisis within their territory.


**Keywords:** Local Authority, Climate Change
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Microfabrication-Based Rational Design of Transcriptional-Metabolic Intervention for the Treatment of Hepatitis C Virus (HCV) Infection' to be submitted under Seventh Framework.

assistant: **Abstract**

Hepatitis C Virus (HCV) infection affects over 3% of the world population and is the leading cause of chronic liver disease worldwide. Current treatments are effective in only 50% of the cases and associated with significant side effects. Therefore, there is a pressing need for the development of alternative treatments. Recently, our group and others demonstrated that the HCV lifecycle is critically dependent on host lipid metabolism. In this context, we demonstrated that the grapefruit flavonoid naringenin blocks HCV production through PPAR± and LXR±, transcriptional regulators of hepatic lipid metabolism. While these results are promising, our ability to rationally control metabolic pathways in infected cells is limited due to an incomplete understanding of the regulation of hepatic metabolism by its underlying transcriptional network. This project aims to develop a comprehensive model of hepatic metabolism by integrating metabolic fluxes with transcriptional regulation enabling the rational design of transcriptional-interventions which will minimize HCV replication and release. Our approach is to develop two microfabricated platforms that will enable high-throughput data acquisition and a human-relevant screening. One component is the Transcriptional Activity Array (TAA), a microdevice for the high-throughput temporal acquisition of transcriptional activity data. The second is the Portal Circulation Platform (PCP) which integrates intestinal absorption module with a liver metabolism compartment enabling the high-throughput human-relevant screening of treatments as a substitute to animal experiments. This work will lead to the development of novel drug combinations for the treatment of HCV infection and impact the treatment of diabetes, obesity, and dyslipidemia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Lung cancEr fusiOn geNes: a new dIagnostic Device'.

assistant: **Innovation**

The main scope of LEONID project is the development and validation of the clinical performance of a new diagnostic Nanostring-based device against existing standards (FISH and IHC) for the detection of in vitro biomarkers with predictive power of response to tyrosin kinase inhibitors used for lung cancer treatment. The device will be the first CE-IVD kit that detects all ALK, ROS1 and RET rearrangements with known and unknown partners in one multiplex assay and that, at the same time, identify the main variants of EML4-ALK.The clinical validation will be extended to the associated software for secondary analysis of data that will guarantee the results standardization, avoiding any personal interpretation. The new diagnostic device-software combination, that passed the technical feasibility analysis and is ready for experimental verification, will be the easiest, cheapest, fastest and standardized solution for ALK, ROS1 and RET fusions detection without losing sensitivity, specificity, robustness and reproducibility.The end users will be all molecular pathology laboratories supporting hospitals where lung cancer patients are treated, that (are going to) perform the analysis of fusion genes and want to reduce hands-on-time, error rate, and costs, saving specialized technical expertise and increasing the throughput of biomarkers and samples. At least 85 European medium-high throughput labs running 450 lung samples per year can be considered as potential customers.For Diatech Pharmacogenetics, the new device will be complementary to the existing products for pharmacogenetics analysis in oncology and will boost the company’s approach of potential European distributors. GeneticLab can offer the test to low throughput labs and can speed up the entrance into the oncology busine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Transcription complex dynamics controlling specific gene expression programs' (TRANS-REG).

assistant: **Concept**

In the pathways of gene expression, by which information is transferred from DNA to end-up with a functional protein, the first regulated and in most cases rate-limiting step is the process of transcription. Despite the detailed picture that is emerging about the composition of the RNA polymerase-ll machinery, a great number of conceptual as well as mechanistic questions are still needed to be resolved before we can attain a complete picture of the principles employed by living organisms to control this process. One of the main gaps in our knowledge is the limited insight we have on transcription regulation in the nuclear environment. The dynamic association of RNA polymerase-ll with general transcription factor complexes within the nucleus, the trafficking of the components between nuclear structures, the forces governing complex-complex interactions and the pacemaker of their intrinsic dynamics at the DNA-protein surfaces of the genes is poorly understood.The general goal of the network is to obtain a comprehensive knowledge on the mechanism of regulation of model genes during cell differentiation, cell proliferation and signal transduction. The network will undertake concerted efforts to develop and apply fluorescent imaging techniques, coupled with genetic, proteomic and conventional molecular and cell biology approaches to study the molecular characteristics and functions of individual multiprotein complexes and their dynamic interplay in the context of unique chromatin structures in living cells.Successful execution of the project is expected to result in:i. New knowledge on the in-situ dynamics of RNA polymerase-ll machinery,ii. New knowledge on the molecular mechanism of transcription regulation that leads to pathway-specific gene expression programs,iii. Develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multiscale mechanobiological synergies  in vascular homeostasis, ageing and rejuvenation' under Horizon Europe.

assistant: **Concept**

Whilst 30% of EU citizens will be over 65 and 10% over 80 by 2050, the healthspan accounts for only 80% of the total life expectancy according to Eurostat, due to the high prevalence of disabling diseases related to the age-induced arterial stiffening. The current paradigm in medicine is to palliate these diseases with sophisticated devices. In JuvenTwin, I propose a complete shift of paradigm by combatting the mechanobiological effects of vascular ageing. Vascular rejuvenation faces many challenges that have only been explored by molecular biologists. My ambition is to address these challenges with a high-risk approach relying on multiscale digital twins and enabling to simulate and screen effective rejuvenation treatments. My hypothesis, already supported by preliminary results, is that this can be achieved by doping the synergistic effects of mechano-regulation in human arteries, which are gradually compromised with vascular ageing. JuvenTwin’s four specific objectives are: 1/ Decipher how ageing affects cell phenotypes and the signalling pathways of mechano-regulation, 2/ Assess the effects of ageing on the mechanical interactions between cells and their matrix, 3/ Simulate computationally the multiscale synergies participating to patient-specific vascular mechano-regulation and finally 4/ Take the control of mechanobiology in aged arteries using small molecule inhibitors and cell mechanical stimulations. With my team, we will reach these objectives by developing two completely novel methodologies: a 4D high-resolution strain mapper and a micromechanical computational model simulating the dynamical interactions of 100,000 vascular cells in patient-specific arteries. Our interdisciplinary approach combining digital spatial transcriptomics, laser interferometry and ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Making of Monoculture: A Global History' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Monocultures are one of the great projects of industrial modernity. From the corn fields of Iowa to date palms in the Sahara, from banana plantations in the Americas to eucalyptus trees in India – wherever we look, we find large production regimes that focus on a single commodity. They supply the lion’s share of the world’s food and create a plethora of economic, social, political and environmental problems. However, there is a great paradox behind the global hegemony of monocultures: they thrive in the absence of a clear paradigm. There is no biological theory of monoculture – and plenty of evidence for the benefits of biological diversity.The project brings historical research to bear in a field that is traditionally the province of agronomists and activists. In the best tradition of global history, it reveals what isolated case studies have failed to see: problems, solutions and actors were surprisingly similar in otherwise different monocultures around the world. Based on carefully selected case studies and intensive communication with experts from forestry and the agricultural sciences, the project identifies the common patterns in the trajectories that monocultures followed around the world and uses that for a new interpretation of the growth and resilience of monocultures that only a historian can provide: a global narrative of recurring crises, of externalizing costs, and of an ever-growing path dependency. Monocultures are stumbling on in spite of the costs because the price of reverting course seems even greater. Outputs include five monographs, culminating in a path-breaking synthesis. The project seeks to challenge existing boundaries between historical subdisciplines and explore the common ground between agricultural history, forest history, environmental h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Study of the role of BANK1 in antibody production and antibody-independent functions of B cells in SLE' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Systemic Lupus Erythematosus (SLE, Lupus) is a life-threatening and incurable autoimmune disease that affects primarily women, its pathogenesis is related with an exaggerated B cells activation that results both in the generation of antibodies against self-nuclear acid antigens and in the generation of subsets of B cells that can exert antibody-independent roles in Lupus. However, the mechanisms that regulate aberrant B cell functions are poorly understood. In this project, we propose to investigate the role of the B cell scaffold protein with ankyrin repeats 1 (BANK1) in the B cell activation signaling pathways in a mouse model of Lupus. We have previously reported that the absence of BANK1 signaling in mice susceptible to Lupus resulted in the reduction of the activation of B cells, circulating total IgG2c and IgG autoantibodies, pro-inflammatory cytokines, and transcription factors related with TLR7 activation. Our data suggest that BANK1 is an important mediator of B cell hyperactivation. We hypothesize that BANK1 plays an important role in B cell signaling affecting their activation and effector functions in Lupus, however we do not fully understand yet the mechanism behind the function of BANK1. Our specific aims are: 1) to define how BANK1 signaling drives class switch recombination, 2) to determine the mechanism by which BANK1 regulates the cytokine production in B cells, and 3) to examine the participation of BANK1 signaling in the differentiation of pathogenic B cell subsets. To accomplish our objectives, we will use flow and mass cytometry, RNA-based next-generation sequencing (RNA-seq) analysis, the assay for transposase-accessible chromatin followed by deep sequencing (ATAC-seq), and a chromatin immunoprecipitation (ChIP) assay. We expect that the results o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Towards spin qubits and Majorana fermions in Germanium self-assembled hut-wires' (SPAJORANA) under Seventh Framework.

assistant: **Objectives**

A renewed interest in Ge has been sparked by the prospects of exploiting its lower effective mass and higher hole mobility to improve the performance of transistors. Ge emerges also as a promising material in the field of spin qubits, as its coherence times are expected to be very long. Finally, it has been proposed that strained Ge nanowires show an unusually large spin orbit interaction, making them thus suitable for the realization of Majorana fermions. In view of these facts, one is able to envision a new era of Ge in information technology.The growth of Ge nanocrystals on Si was reported for the first time in 1990. This created great expectations that such structures could provide a valid route towards innovative, scalable and CMOS-compatible nanodevices. Two decades later the PI was able to realize the first devices based on such structures. His results show that Ge self-assembled quantum dots display a unique combination of electronic properties, i.e. low hyperfine interaction, strong and tunable spin-orbit coupling and spin selective tunneling. In 2012, the PI’s group went a step further and realized for the first time Ge nanowires monolithically integrated on Si substrates, which will allow the PI to move towards double quantum dots and Majorana fermions. In view of their exceptionally small cross section, these Ge wires hold promise for the realization of hole systems with exotic properties.Within this project, these new wires will be investigated, both as spin as well as topological qubits. The objective of the present proposal is mainly to: a) study spin-injection by means of normal and superconducting contacts, b) study the characteristic time scales for spin dynamics and move towards electrical spin manipulation of holes, c) observe Majorana fermions in a