RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Prediction of Air Pollution in Latin America' in the context of a Horizon 2020 call.

assistant: **Objectives**

The overall objective of the PAPILA project (Prediction of Air Pollution in Latin America and the Caribbean) is to establish a sustained network of partners with complementary expertise, which will develop and implement an analysis and forecast system for air quality with downscaling capability for Latin America and the Caribbean region (LAC region), and assess the impact of air pollution (background and peaks) on health and on the economy. This forecast system will help decision-makers improve air quality and public health, and avoid the occurrence of acute air pollution episodes, particularly in urban areas.The project combines an ensemble of state-of-the-art models, high-resolution emission inventories, space observations and surface measurements to provide near real time forecasts and analysis of regional air pollution in the LAC region. To reach this objective, the project will bring together an interdisciplinary team of scientists from Europe, Latin America (Argentina, Bolivia, Brazil, Chile, Colombia, Mexico, Venezuela) and the Caribbean (Puerto Rico), and foster synergies between the groups involved in research and service activities. The project will co-develop with users and other stakeholders several products and services of importance for the LAC region. An important objective of the project is to make use of complementary competence to develop innovative ideas, to established sustained partnerships between research groups, to transfer information to the public, to develop educational activities and to create a dialogue with interested stakeholders. Societal impacts, specifically on human health, on crop production, on ecosystems, on the mountain snow cover and on the hydrological cycle as well as the economic benefits of mitigation policies will be assessed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Novel map-population and rendering techniques for reinventing massively multiplayer online computer games'.

assistant: **Innovation**

Computer games are experiencing an incredible evolution. With 2.2B gamers across the globe (25% of the EU online population playing video games), this industry has a constant demand for new creative approaches, essential to maintain players' loyalty in a very demanding market. In MMORTS games (Massively Multiplayer Online Real-time Strategy), spatial representation in hex-maps has a huge impact on how engaging a game is. But current approaches for hex-map population/rendering are suboptimal when applied to the latest tendencies in MMORTS, which assume thousands of simultaneous online players and lead to massive hex-map dimensions. STARBORNE brings a set of novel technological developments, based on Artificial Intelligence, for solving these problems: (1) a unique 3D-maps Procedural Generation Engine, that makes the creation of large in-game 3D maps much easier; (2) a new rendering method, enabling dynamic visualization of large 3D maps without over-taxing the processing capacity of players' computers; and (3) a single-game experience across all platforms that leads to a more immersive playing experience. We take advantage of these novelties not only to reduce the cost and time-to-market of our future products, but also to introduce a totally novel innovation in the MMORTS genre: a 3D map capable of hosting over 25K players, with no rendering delays and running on modest players' hardware. This creative-technological combination will greatly increase player retention, leading to considerable revenue growths and global market share. Time-to-market (so costs) will substantially decrease too, enabling impressive fast development of current and future games. Grown over the achievements of our current alpha-testing results, that has already generated much excitement in the ga
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Characterization of Reactive Oxygen Species as Innate Immune System Mediators that Control Inflammation', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Biomedical research in the post genomic era will depend on the establishment of collaborative efforts between clinical and preclinical researchers, combining bedside medical research with experimental science. This project stems from initial gene expression studies on immune compromised patients with severe inflammatory disorders. The results allowed us to generate the hypothesis that reactive oxygen radicals are key anti-inflammatory agents in the immune system. We also embrace the novel idea that it is possible to stimulate an innate immune response without exciting harmful inflammation and moreover, that it is possible to identify molecular regulators as potential therapeutic targets that allow such an immune response. The proposed project will be multidisciplinary, incorporating old and new technologies in both the wet and dry lab environments that combine aspects of immunology, cell biology, bioinformatics and clinical microbiology. It will constitute the first comprehensive study of the role of oxygen radicals in inflammation and immunity outside the traditionally described roles of radicals in oxidative microbial killing and neutrophil apoptosis. In addition, it will highlight a novel set of immune regulators with therapeutic potential and provide a template for future biology-based drug discovery platforms that originate in the clinic.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The evolutionary dynamics of pathogen emergence and establishment: from Reservoir Detection to Outbreak Control' (ReservoirDOCs) under Horizon 2020.

assistant: **Objectives**

Extracted evolutionary and epidemiological information from pathogen genomes has grown into an important instrument across infectious disease research. By harnessing such information, molecular epidemiologists aim to shed light on the origin and epidemic history of pathogens, from reservoir dynamics to emergence and adaptation to new hosts, and their spatiotemporal spread. However, despite the revolution in genome sequencing technologies and advances in statistical methodology, key questions about pathogen emergence and establishment in human populations remain unresolved for major viral epidemics. When confronted with new viral outbreaks, such as the recent devastating Ebola virus epidemic, we also struggle to deploy these technologies in a systematic and concerted way despite a critical need to support public health interventions.In this project, we propose to unravel crucial steps in the emergence and establishment of key viral pathogens. We will scrutinise the reservoir dynamics of HCV by sequencing complete hepacivirus genomes from infected samples emerging from a large-scale screening of African rodents, and analyze the cross-species transmission history using novel evolutionary methods that accommodate spatial and temporal variability in selective pressures. To test hypotheses about the early establishment of HIV-1, we will carve a genomic window into the past epidemic history of the virus by integrating molecular work on archival samples from Central Africa and on samples representative of the current HIV-1 diversity, with the development of ancestral recombination graphs that accommodate dated tips and spatial diffusion, as well as population dynamic models that incorporate epidemiological information. Finally, we will take the recent Ebola epidemic in West Afr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Structural Dynamics of Proton Pumps' (SDPP) targeting Fourth Framework.

assistant: **Abstract**

The principal objective of this proposal is to carry out a comprehensive program in structural biology to understand the mechanism of proton pumping by membrane bound proton pumps. The first work package aims at a determination of the three-dimensional atomic structure of bacteriorhodopsin(bR), one of natures light driven proton pumps, recorded at different time points in the photo cycle. The intermediate states in the photo cycle will be recorded using single crystals of bR combined with millisecond to picosecond diffraction techniques. The combination of high quality crystals, two photon reaction initiation and short x-ray pulses should make it possible to record the structure of the K. L and M intermediates at high resolution which is expected to pinpoint the proton translocation pathway. Complimentary experiments will exploit the temperature dependence of the photo cycle and isolate the intermediates by freeze trapping. Moreover crystals of bR mutants with longer lived intermediates will also be studied. In the second work package we will examine chemically driven proton pumps by looking at oxygen reduction in the haem-containing respiratory oxidases quinol oxidase, cytochrome oxidase, and cytochrome cdl. These enzymes diffract to high resolution and are active in the crystal. Fast diffraction methods combined with spectroscopic techniques will be used to correlate electronic transitions with structural transitions. These techniques will be used to produce a three-dimensional movie of oxygen reduction by respiratory oxidases. The experiments are expected to reveal the oxygen chemistry in cytochrome c oxidase, which will aid our understanding of proton pumping in such enzymes. The studies will allow us to see how redox energy can be switched into conformational energ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'DAFNE: Use of a Decision-Analytic Framework to explore the water-energy-food NExus in complex and trans-boundary water resources systems of fast growing developing countries.'.

assistant: **Innovation**

Global trends in population growth and rising economic prosperity will increase the demand for energy, food and water, with more severe impact in fast-growing economies, such as in several African countries. The constraints on water, energy, and food could well hamper economic development, lead to social and geopolitical tensions, and cause lasting environmental damage. DAFNE advocates an integrated and adaptive water resources planning and management approach that explicitly addresses the water-energy-food (WEF) nexus from a novel participatory and multidisciplinary perspective. This includes social, economic, and ecologic dimensions, involves both public and private actors and is socially inclusive, enhances resource efficiency and prevents the loss of ecosystem services in regions where large infrastructures exist or are being built and intensive agriculture is expanding. A decision-analytic-framework (DAF) will be developed to quantitatively assess the social, economic, and environmental impact of expanding energy and food production in complex physical and political contexts, where natural and social processes are strongly interconnected and the institutional setting involves  multiple stakeholders and decision-makers. The DAFNE approach will be demonstrated by analysing two cross-boundary case studies, the Zambezi and the Omo river basins. The WEF nexus will be quantified and analysed as the trade-off between conflicting objectives such as hydropower production vs irrigation, land exploitation vs conservation, etc. The nexus will be translated in economic values and impact on growth, ecosystems and ecosystem services. DAFNE will allow a better understanding of the WEF nexus, and generate and explore alternative planning and management solutions based on the cooper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A participatory approach for soil and water conservation planning, integrating soil erosion modeling and land evaluation, to improve the sustainabi lity of land use on the Loess Plateau in Northern China', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The aim of the research is to develop alternative land use and conservation strategies on the Loess Plateau in China, using a participatory planning method which integrates both soil erosion modeling and land evaluation techniques. Motive is that soil erosion is the major cause of degradation of agricultural and non agricultural land on the Loess Plateau in the northern provinces of China, inhibiting sustainable use of the land resources. A new participatory planning method, which integrates both soil erosion modeling and land evaluation, will be used. Prospective alternative land use and conservation measures, resulting from the land evaluation process, will be evaluated on their effects on reducing soil and water losses using a recently developed, GIS incorporated, physically-based soil erosion model. Based upon model outcome, alternative land use and conservation measures will be refined and optimized in a participatory process. In the participatory process, land users, local authorities and policy makers will be involved in order to reach an optimum situation (low soil and water losses, high sustainability) for the selected watersheds. The solutions found in this approach are expected to be supported by the different user groups in the area, which will provide a good basis for a successful implementation after conclusion of the project.Expected Outcome* A project summary discussing the results of all research activities undertaken within the project.* The extended LISEM, with inclusion of a gully erosion submodel, capable to compute soil and water flows at the watershed level.* Publications in national and international technical and scientific journals.The key activities involve :* Performing a land inventory in the selected watershed on the Loess Plateau in China,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Monolithic MicroColumn Gas Sensor System: a system for portable low power high selectivity gas analysis' in the context of a Horizon 2020 call.

assistant: **Objectives**

MicroColGaSe (Monolithic MicroColumn Gas Sensor System: a system for portable low power high selectivity gas analysis) is an action aimed at the development and characterization of a novel microfabrication platform allowing the monolithic integration of a microfluidic separation microcolumn with a gas sensor fabricated with Micro Electro-Mechanical Systems (MEMS) technology. A range of new MEMS microfluidic enhanced sensors can emerge from this platform. The primary result of this action is an ultra compact, low power consumption, high selectivity gas sensing system-on-chip. This novel integrated system is meant to enable high selectivity in mobile gas sensing devices which are forecast to become part of the consumer market in lead applications such as IoT, healthcare, environmental monitoring.Although MEMS gas sensors have been researched during the last 20 years and marketed in the last decade, their selectivity remains an intrinsic limit due to the nature of the detection principle. This action aims at providing high selectivity MEMS gas sensors using a microcolumn to pretreat the gas sample and obtain flow separation of its components. This is already achieved in complex systems which require multiple separate components to be connected, obtaining bulky and power consuming devices.Main objective of this action is to enable monolithic integration of the main components of the above described system: gas sensor, microcolumn, concentrator and filter - all in a single silicon chip. The dramatic advantages of this integration are in the cost, footprint, and energy efficiency. In particular, the extremely reduced footprint will make it possible to embed these sensors in consumer mobile devices such as smartphones and wearables. A network of partners will allow a complete
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fluorescence intraoperative imaging platform for tumor margin delineation' under Seventh Framework.

assistant: **Concept**

According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. Among the distinct types of cancer treatments, surgery, which is the oldest modality, is still often confronted with difficulties in the identification of cancer spread and the accurate delineation of tumor margins. This is of uttermost importance in order to infer the lowest harm to the organ where the tumor originated but without leaving residual tumor. This proposal is intended to improve the surgical outcome, employing a highly sensitive fluorescence imaging approach, which holds a strong potential to become a key technology in intraoperative imaging.The primary goal is to employ real‐time multi‐spectral fluorescence imaging for sensitive and quantitative molecular visualization of infiltrating cancer, which can enable real‐time surgical feedback and improved surgical outcome over the current state of the art and clinical practice. For this goal an advanced multi‐spectral fluorescence imaging system that can significantly improve quantification and the observation accuracy over simple fluorescence video systems considered in the past, will be developed. Further promising new fluorescence probes will be utilized and their ability to offer high detection sensitivity and specificity of tumor margins will be investigated. The performance of this approach will be examined in controlled phantoms and in‐vivo in breast cancer and abdominal cancer in animal models. Moreover, the method will be examined in relation to offering real‐time pathology of lymph‐nodes in‐vivo.If this proposal is successful, it will lead to the development of an accurate imaging platform that can enhance surgical vision while seamlessly integrating in the operating surgical room. Due to the direct relation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'iodine Fed Advanced Cusp field Thruster for Mid-Power', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

iFACT-MP (iodine Fed Advanced Cusp field Thruster for Mid-Power) aims to develop an iodine fed thruster subsystem for the 3-5 kW range. The activity will include work on all the critical building blocks required to enable the realisation of an iodine EP subsystem. This encompasses the upscaling of the Advanced Cusp Field Thruster (ACFT) to that power range at Airbus Friedrichshafen and the development of the fluidic chain at Airbus Toulouse, consisting of the heated iodine reservoir, piping and flow control for the thruster as well as the neutraliser. Further, the necessary verification and formalisation of the fluidic design and iodine handling procedures will be performed to enable the implementation and integration of iodine EP subsystems on platform level. A major building block required to enable a completely iodine based EP chain is an iodine fed neutraliser. For this purpose, further improvements and modifications on C12A7 emitter ceramics will be performed by Fraunhofer IKTS, in close collaboration with the iodine cathode development at Airbus. To validate the necessary control and operational schemes, a breadboard PPU will be developed by Airbus Elancourt that includes all the required supplies, telemetry and functionalities to enable autonomous control of the thruster subsystem. To enable rapid and accurate characterisation of the developed thruster subsystem's performance, an optical iodine flow meter will be developed and integrated by University of Pisa. As currently no test facility exists to perform thruster testing at that power level, a suitable iodine compatible vacuum chamber including a thrust balance and diagnostics will be developed at Aerospazio. This facility will enable full characterisation and 500 h endurance testing of the developed thruster