RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Comparative analysis of primate genomes, transcriptomes and proteomes with an emphasis on cognitive capabilities' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The biological basis of the unique human features separating us from even our closest relatives, the chimpanzee, constitutes one of the most fascinating problems in biological research. Based on the sequence of the human genome, the recently completed finished sequence of chimpanzee chromosome 22, the recently released draft sequence of the chimpanzee genome, as well as additional gene sequences in other primates (e.g. Clark et. al. 2003), we plan to identify likely candidates for playing an essential role in the molecular basis of these differences. This will particularly include genes with potentially novel functions in man, formed by fusion events between pre-existing genes or pre-existing genes with repetitive elements, genes showing accelerated evolution i n the human lineage, with appropriate expression patterns (or human specific changes in expression patterns), and appropriate molecular or cellular function, as well as the orthologs of genes identified as being involved in cognition differences in the mouse.Candidate genes selected by this process will be analysed by evolutionary shadowing of their promoters, as well as, in some cases, coding and other regulatory regions, by in-situ hybridisation of mouse orthologues in the postnatal mouse brain, and where appropriate, by in-situ hybridisation in the brains of selected primates, complemented by a range of other techniques available at the different centres. Moreover, selected candidate genes for higher cognitive capabilities will be studied in vivo in the common marmoset monkey. Data generated within this project will be made available to collaborating groups in a special project data base, analogous to genome-matrix (http://www.genome-matrix.org), a common functional genomics database developed jointly by the M
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Towards Rational Understanding of the Fe-quarterpyridine-mediated CO2 Reduction to Solar Fuels'.

assistant: **Objectives**

The reduction of atmospheric CO2 to useful chemicals and fuels has been established as one of the most promising, clean and renewable alternatives to fossil fuels. Although the field has grown enormously during last years, information regarding mechanism and transient intermediates formed during the catalysis is still limited.TRUSol aims to explore the mechanism and the factors that control catalytic performance through the rational design of ligands and spectroscopic studies. With this goal in mind, we develop a strategy to synthesize a novel family of Fe-based quarterpyrine-based CO2 reduction catalysts. The new complexes will be tested photocatalytically, combining the molecular catalysts with mesoporous carbon nitride (mpg-C3N4) as semiconductor. The comparison of the complexes with fine-tuned ligands in regard to redox properties and photocatalytic activities will help to elucidate key aspects that govern kinetics and thermodynamics under turnover conditions. Complexes will first be explored under steady state and operando conditions by using a spectroscopic tool-kit including EPR, Mössbauer, X-ray absorption and emission spectroscopy to shed light on the electronic structures. Then, taking advantage of the ability of synchrotron techniques to selectively irradiate the metal center, laser/X-ray pump/probe time-resolved X-ray absorption and emission spectroscopy will investigate the highly reactive and/or short-lived transient intermediates in ps-ns time scales. TRUSol will put the fellow in a perfect position to achieve his career goal, a tenure track position in academia, through transferable skills such as project management, and scientific and personal training actions of the project. This interdisciplinary project promises a valuable mechanistic understanding t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Genetic diversity of Stone Fruit trees (Peach, Apricot and Cherry) in Europe, Caucasus and Central Asia'.

assistant: **Innovation**

The STONE project addresses scientific issues related to stone fruit (Prunus species) biodiversity. In a worldwide competitive context, stone fruit breeding programmes have to face new challenges regarding the maintenance of high quality fruit production under a changing climatic environment and increasing threats from pathogens, especially the sharka disease. STONE is a four years coordinated joint programme of staff exchange for short and medium periods between two European organisations, an associated and two ICPC third countries. The IRSES scheme is designed to provide opportunities of mobility to researchers and support research organisations. It integrates existing bilateral collaborative activities into a coherent long-term multinational programme addressing a key issue to two high priorities on the political agenda of the EU, i.e sustainable agricultural fruit production and biodiversity. The programme of exchange is intended to develop common tools and to jointly use these tools for the comparison of the genetic biodiversity in the European, Caucasian and Central Asian Apricot, Peach and Cherry germplasms. The project objectives include the assessment of the genetic diversity at selected loci directly affecting response to virus infection and to climate changes. The range of common fruit tree species of interest and of climatic conditions, as well as the strategic importance of fresh fruit production in all the countries involved will provide a coherent framework and socio-economic background for the planned research activities. Three topics have been identified as most relevant for all partners involved in the STONE project: assessment of the broad genetic diversity at the centers of origin and along the expansion routes of Prunus species after domestication a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Feedback mechanisms in models for ecological forecasts' in the context of a Sixth Framework call.

assistant: **Objectives**

Environmental change poses a major threat to the maintenance of biodiversity and ecosystem services in this century. Management strategies that counteract this threat need to be based on forecasts of the impact of environmental change (changes in land use and climate, biological invasions, nutrient enrichment, etc.) on ecological systems at various hierarchical levels (populations, communities and ecosystems). Mathematical models are indispensable tools for the development of such ecological forecasts. However, most models ignore the hierarchical feedbacks between the dynamics of communities, populations and genotypes that critically affect the response of ecological systems to environmental change.FEMMES aims1. to better understand such hierarchical feedback mechanisms,2. to incorporate them into ecological models, and3. to use these models to identify management strategies.This requires a complement to the host's broad experience in theoretical and empirical ecology through transfer of knowledge on evolutionary, food web and systems theory. In particular, to determine the response of ecological systems to environmental change, we need to better understand and model feedbacks between(1) demographic and evolutionary processes,(2) communities and individual populations, and(3) the dynamics of communities, populations and genotypes.FEMMES will enable the host to develop a new area of competence in formulating ecological forecasts that explicitly account for hierarchical feedback mechanisms. This will help to better forecast and manage the effects of environmental change, and to overcome the lack of suitably trained ecological theoreticians and modellers that prevails throughout Europe. FEMMES will contribute to the priority theme 'Sustainable Development, Global Change an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Advanced analysis of multiparametric volumetric ultrafast ultrasound: a novel approach for non-invasive breast cancer diagnosis'.

assistant: **Objectives**

Tumour development follows a diversity of complementary biological pathways, including the modification of the tissue structure and vascularization, which are not currently captured by imaging techniques in the clinic. Breast cancer patients undergo a series of imaging sessions using complementary modalities, including ionizing mammographies. In many cases, this imaging is not precise enough for a diagnosis, so that tissue samples in the form of biopsies are used to further characterize the tumour and determine the appropriate treatment. Beyond the pain and stress associated with biopsies, this complex process is costly and time consuming, and delays the time to diagnosis.Ultrasound B-mode imaging is largely used in the diagnostic process of breast cancer, in part because it is low cost, portable and largely available, as well as non-ionizing and non-invasive. Our laboratory, Institute Physics for Medicine Paris has recently developed several quantitative techniques allowing for the measurement of tissue stiffness, fiber organization, and vascular mapping, all relevant to tumour development. In this project, I propose a new approach to diagnosing breast cancer non-invasively by applying machine learning analysis to rich volumetric multiparametric maps of complementary tumour aspects, obtained using these innovative ultrafast ultrasound techniques. The project will tackle the technological challenge of integrating these techniques into a common acquisition and analysis framework, and include the collection of a large clinical dataset and the development and validation of a predictive malignancy model informing on tumour characteristics for the diagnosis. This approach will open the door to fully virtual biopsies, impacting society on a large scale in terms of cost, diagn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Transient directing group for catalytic distal C–H functionalisation' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The development of methods for the transition metal (TM) catalyzed functionalisation of C–H bonds has emerged as an extremely important topic in present-day organic synthesis aiming at providing tools that allow treating the ubiquitous and normally inert C–H bonds as any other functional group for synthetic modifications. However, controlling the site of C–H activation or distinguishing between the subtle differences in reactivity of two given C–H bonds is one of the major challenges yet to be addressed. In this context, meticulous design of directing groups (DG) over the last decades has enabled a variety of relatively unreactive C–H bonds to be functionalised under transition metal catalysis. To date, much progress has been made in developing strategies for the ortho-functionalisation of arenes mainly through the installation of DGs in the stoichiometric amount. However, these DGs are not part of the final target molecule; as a consequence, its covalent installation and/or removal from the substrate will add additional steps to the synthetic sequence thus lowering the efficiency and applicability of these approaches. On the other hand, distal meta- and para-C–H functionalisation approaches, are extremely scarce despite these substitutions are widespread motifs amongst biologically active molecules.  The research outlined in this proposal aims at developing a process that makes use of a transient DG in a catalytic amount which binds reversibly with carbonyl compounds via imine formation leading to a novel direct meta- and para-functionalisation methodology. Precisely, we seek to develop a protocol that removes the need for the use of stoichiometric directing groups to activate distal C–H bonds.  The realization of the proposed objectives will push the boundaries of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Strengthening the European Court of Human Rights: More Accountability Through Better Legal Reasoning' (ECHR).

assistant: **Innovation**

Human rights are under pressure, in Europe as elsewhere, due to several developments, namely [1] War on terror: the pressures generated by competing discourses [2] Coping with the dangers of rights inflation [3] Conflicting rights: how to handle rights as contested claims [4] The challenges of dealing with universality under fire In this context, the human rights leadership of the European Court of Human Rights is of crucial importance. Yet the Court is not fit for purpose. Inconsistencies and sloppy legal reasoning undermine both its credibility and the impact of its decisions. The research programme that I propose will strengthen the consistency and persuasiveness of Court s legal reasoning so as to improve its accountability and transparency. My aim is to identify new technical solutions for important human rights problems, by the development and application of creative methodologies. The substantive innovations within the field of European human rights law that I propose to make are: [a] the development of new legal tools, which will consistently integrate the accommodation of the particularities of non-dominant groups into the reasoning of the European Court of Human Rights [b] the development of a new theoretical framework combining minimum and maximum approaches to human rights protection, followed by its translation into clear legal criteria for use by the European Court of Human Rights [c] the development of a script that will enable the adoption of a consistent approach by the European Court of Human Rights to conflicts between human rights My methodological approach is characterized by the combination of empirical and normative dimensions, a 360° comparison, and the integration of qualitative research methods (interviews and focus groups with key stakeholders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Short supply chain Knowledge and Innovation Network' (SKIN).

assistant: **Concept**

SKIN is an ambitious initiative of 20 partners in 14 countries in the area of Short Food Supply Chains (SFSCs). It intends to systematise and bring knowledge to practitioners, promote collaboration within a demand-driven innovation logic and provide inputs to policymaking through links to the EIP-AGRI. SKIN will build and animate a community of about 500 stakeholders, with the strategic objective of setting up, at the conclusion of the project, a European association permanently working for the improvement of SFSCs efficiency and for the benefit of stakeholders and growth in the sector. The community will be built and animated around the identification of good practices in short supply chains across Europe. Partners will scout, analyse and classify a significant number of cases in different countries. “Best practices” (at least 100) will be systematised, processed into highly usable formats (including video and page-flows) and made accessible to stakeholders via the web (following the EIP AGRI formats) and through the set-up of regional nodes, to allow a deeper penetration of existing knowledge into practice. The work on good practices will also allow identifying key issues (hindrances or opportunities) around SFSCs. Such issues will be the main themes of 6 “innovation challenges workshops” the purpose of which is to stimulate stakeholders to propose new ideas for innovation based research or innovation uptake. These will be supported in a coaching phase where consortium partners deliver guidance to stakeholders for the full development of those innovative ideas.SKIN puts significant efforts in dissemination, to reach as many stakeholders as possible, and exploitation, to plan post projects developments in the form of a permanent association that would give continuity t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Improving the Capacity and Usability of EUROMOD'.

assistant: **Concept**

EUROMOD is a tax-benefit microsimulation model covering all 15 current Member States (MS) of the EU. It enables research on the effects of policies and policy reforms that have an impact on incomes, poverty, inequality and social inclusion. It has been de liberately constructed to be independent of any single theoretical or disciplinary perspective, as a platform on which users can implement their chosen approaches. EUROMOD is not only of relevance to social scientists but also of potential value to polic y practitioners, as the model itself embodies a knowledge base about different and changing national policy structures and systems within a comparative framework. The aim is to re-design and up-grade EUROMOD in the light of (a) enlargement and (b) the le ssons learned from operating the first, prototype version. The proposed feasibility studies and technical preparatory tasks are structured so that together they provide the basis for (1) increasing EUROMOD's capacity to address a very wide range of socia l science questions (2) incorporating the 10 new MS (3) improving ease of use and accessibility (4) improving the quality of results by enhancing comparability across countries and (5) reducing the resources necessary to maintain, update and develop EURO MOD in the future. The study will be overseen by a User Group who will test the new components and advise on the various trade-offs and choices as they emerge. As well as laying the technical basis for a 25-country comparative research infrastructure, I-C UE will involve researchers from the 10 NMS in the long-standing EUROMOD collaboration. Together with design up-grades and greater clarity in presenting the knowledge base embodied in the model these developments will prepare for a planned new phase of e xtending acce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Invariant Natural Killer T-cells in atherogenesis'.

assistant: **Concept**

Many survivors of childhood chronic disease struggle with early atherosclerosis later in life. As a physician-scientist I am inspired by their lifelong fight, and my research focuses on the etiology and treatment of early atherosclerosis. Here, I aim to unravel the role of invariant Natural Killer T-cells (iNKTs) in atherogenesis. iNKTs are unique for their restriction to lipid antigens presented on CD1d molecules, which underlies their pivotal role in lipid-driven disorders such as atherosclerosis. The exact role of iNKTs however remains elusive, as long as the involved plaque-associated lipid antigens have not been identified. Therefore, I developed CD1d-sortagging as a novel and innovative approach for lipid antigen identification. CD1d-sortagging employs bacterial sortase enzymes for site-specific cleavage and biotin labeling of CD1d-lipid antigen complexes, followed by isolation and mass spectrometry identification of the lipid antigens. At the Cardiovascular Immunology laboratory of Prof. Monaco at the Kennedy Institute of Oxford University, in a unique collaboration with renowned iNKT-glycolipid expert Prof. Cerundolo, I first aim to identify plaque-associated lipid antigens. CD1d-sortagging will be applied ex vivo in a human atheroma model, and in vivo in a CD1d1-sortagging mouse model for atherosclerosis. Upon identification, I secondly aim to unravel the impact of plaque-associated lipid antigens on iNKT cell phenotype and function using Mass Cytometry of plaque-resident immune cells and study the structural and functional aspects of plaque lipid-iNKT cell interaction. Finally, I will explore the therapeutic potential of plaque-associated lipid antigens to manipulate iNKT cell function and atherogenesis in a mouse model for atherosclerosis. Taken together, thi