RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Chirped quasi-phasematching gratings for optical parametric chirped pulse amplification: physics, devices, and applications'.

assistant: **Innovation**

Chirped (aperiodic) quasi-phasematched (CQPM) gratings offer many advantages in the context of optical parametric chirped pulse amplification (OPCPA), including ultrabroad bandwidths, engineerable gain spectra, and potential for high efficiency via adiabatic frequency conversion. Our main goals are to investigate CQPM devices and apply them to mid-infrared OPCPA systems. We will determine the limiting factors of our current high repetition rate mid-IR OPCPA system, develop an accurate numerical model, and design improved devices. As an example, with optimal nonlinear CQPM profiles, we plan to suppress spectral gain narrowing, and thereby obtain higher efficiencies and broader bandwidths.For future experiments, increases to the power and bandwidth of our existing system are required. We plan to develop an improved seed source based on a 1-micron-wavelength thin disk laser, spectrally broadened via supercontinuum generation (SCG). Concurrent upgrades to the pump laser to hundreds of Watts power are planned. To support these powers, we will explore approaches to scaling the CQPM devices to higher power.Recent developments in SESAM mode-locked thin disk lasers have enabled high-power, short-pulse operation (580 fs, 275 W, 17 microjoules). For some applications, much shorter pulse durations are needed. One way we plan to approach this problem is by performing SCG (seed generation) followed by OPA (for efficient conversion). Due to the short pump pulses, we will develop group-velocity matched CQPM OPCPA designs.With these laser sources, we plan to perform strong-field laser-matter experiments. For example, the high repetition rates and tunability will help us to explore the wavelength scaling of several processes related to high harmonic generation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Functional dissection of X-linked regulatory DNA: unravelling the impact of genome topology on transcriptional regulation' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Mammalian genomes are structurally organized into sub-chromosomal self-interacting domains called topologically associating domains (TADs). Functionally, genes embedded within the same TAD appear to be co-regulated by their shared regulatory landscapes, suggesting the tendency of the genome to be divided into discrete regulatory domains. Although disrupting TAD boundaries has been shown to result in aberrant patterns of gene expression, whether TAD organisation is cause or consequence of transcriptional activity remains largely unknown, as well as the regulatory elements that direct TAD formation and long-range chromatin interactions within TADs. This project aims to define the exact functional link between genome topology and transcriptional regulation by exploiting the mammalian dosage compensation mechanism X-Chromosome Inactivation (XCI) as a model system. First, I will identify the combination of regulatory elements that allow a subset of X-linked genes to resist the transcriptional silencing of one entire X chromosome in female cells. Then, I will characterise their functional and structural relevance by combining advanced epigenetic tools for the manipulation of complex regulatory networks with transcriptomic analysis and chromosome conformation capture, an innovative method that allows to define the 3D structure of chromosomes within the nucleus. This project represents a unique opportunity to enhance our understanding of genome topology, providing valuable insights into the roles of the non-coding genome in gene regulation. Considering my personal professional background, and the outstanding level of scientific excellence of the host institution, this project promises a great potential of radically advancing the field and, in addition, will provide the European
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Cofactors at the core of tau prion behaviour'.

assistant: **Concept**

Tau is an intrinsically disordered protein that regulates microtubule activity in neurons. Aggregation of tau into amyloid fibrils is diagnostic of several diseases, termed tauopathies, that include Alzheimer's disease. Distinct amyloid aggregate structures, so-called ""strains"", are involved in different tauopathies. These assemblies can spread and recapitulate pathological phenotypes when injected in cells and animals. This is the hallmark that tau aggregates follow a prion behaviour. To date, the factors guiding the formation or propagation of specific strains are unknown. Showcasing this crucial gap in knowledge is the fact that none of the brain-extracted tau amyloid structures has been reproduced in vitro. This project intends to establish a paradigm shift for the very definition of tau strain. I propose the novel hypothesis that the co-aggregation of tau with other biomolecules such as lipids or polyanions, so-called cofactors, is a defining property of tau prion strains. To demonstrate this hypothesis, I will test that the tau-cofactor interactions (i) dictate the structure of tau aggregates, (ii) enable structure replication through seeding and (iii) dictate the neuropathology developed in cells and mice after inoculation of tau seeds. My approach is to study the pathological properties and the conformational evolution of tau aggregates in the presence of biologically-relevant cofactors possessing different physico-chemical properties. By mapping the interactions between tau and cofactors, my goal is also to establish the canonical rules governing tau structural differentiation. This proposal combines multiple methods including EPR and NMR spectroscopy, AFM-based nanospectroscopy, biochemistry, cell biology and animal histology. The proposed paradigm shift wou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A Post Growth Deal' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

How can we sustain human well-being within planetary boundaries? What policies and provisioning systems could enable societies to prosper without growth? What politics and alliances are necessary for seeing post-growth policies through, and how can the public be engaged in them? What new scientific paradigm could answer such questions? Societies face multiple intertwined crises. Bold alternatives are sorely needed. This project develops frameworks for ‘Post-Growth Deals’, from empirical research through to practical applications. First, we develop equitable North-South convergence scenarios, modelling human well-being achievement in all countries within planetary boundaries. Second, we articulate post-growth policy packages for the Global North and South, assessing their political acceptability and modelling their effects. Third, we develop models of provisioning systems to ensure future populations have adequate energy, food, shelter, health and social security. Fourth, we learn from political movements, studying politics and alliances that could bring post-growth transitions forward. Fifth, we identify practical steps to bring Post-Growth Deals to life, working with four representative communities to co-produce knowledge and action on the ground.The potential gains of this research are immense: post-growth transitions may unlock a far more ecologically stable and socially prosperous future than current trajectories lead to. REAL brings a paradigm shift moving post-growth science from economics to sustainability studies. We propose a new trans-disciplinary ‘5Ps of post-growth’ science, grounded in resource/energy modelling, political-economy and socio-political analysis – a skill-set that no single researcher or team presently possesses. The PIs are leaders in their fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Disrupting the Migraine continuum of care for resource constrained settings' (TARA) under Horizon Europe.

assistant: **Objectives**

Chronic migraine is defined as a headache persistent for more than 3 months or a severe headache persistent for more than 15 days within a month. It affects approximately 2% of the world population. The World Health Organization classifies severe migraine attacks as among the most disabling illnesses, comparable to dementia and quadriplegia. Treatments start with pharmaceutical drugs, which have contra-indications and severe side effects and often remain ineffective in chronic migraine patients. Injectable treatments like Botox and nerve blocks can be effective but require multiple sessions per year and also have undesirable effects. Treatments using neurostimulation products that deliver electrical pulses to the occipital nerve have been up to 80% effective but they are designed for the back not the neck which results in high rates of surgical revisions. This leaves the chronic migraine population severely underserved and in need of an innovative solution. Our vision is fundamentally based on disrupting the continuum of care and referral pathway by creating a more effective non-surgical solution that reduces cost and risk and therefore increases accessibility to more physicians and patients.The consortium will develop a novel platform for the treatment of chronic migraine that will be particularly applicable to resource restricted environments and targeting underserved patients. We are working on 4 elements working together seamlessly. 1) LUNA-AIR: An implantable electronics device with neural write stimulation 2) LUNA-CONTROL: A wearable device that will communicate with and power the implantable device. 3) LUNA-APP; a mobile app to control the implant. 4) LUNA-INJECT; an ergonomic, minimally invasive, injection device that minimises tissue trauma and training require
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identification of novel KSHV immune evasion mechanisms using a quantitative temporal viromics analysis' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Kaposi’s Sarcoma-associated herpesvirus, or human herpesvirus 8, is an important cause of morbidity and mortality, causing tumors in immunosuppressed patients, in particular those with AIDS. Like other herpesviruses, KSHV has evolved numerous mechanisms of escape from both the innate and adaptive host immune response. These immune evasion strategies facilitate the virus’s oncogenic potential and contribute to its pathogenesis. Beyond immune modulation, many viral proteins interact with components of the cellular proteome to enable viral replication. However, the complete array of such proteins, their kinetics and fate in both latent and lytic phase of viral infection has never been determined. Here, I propose an unbiased proteomic approach to analyze the expression kinetics of the KSHV proteome in the context of cellular infection, and explore how host cell surface and cytoplasmic proteins are regulated by this virus throughout its infection cycle. To achieve this goal I will resolve both the host cell and the viral proteome in primary endothelial cells and B cells using the recently developed technique, quantitative temporal viromics. This novel approach is interdisciplinary, incorporating virology, immunology, cell biology, state-of-the-art proteomics and has been successfully applied to identify novel markers of latent HCMV infection as well as novel immunomodulation strategies. The proposed study will allow a temporal analysis of how the host and viral proteome change upon latent as well as lytic KSHV infection. Newly discovered viral targets, such as ligands for Natural killer (NK) or cytotoxic T cells will be validated and investigated using biochemical and virological methods available in the host (Lehner) lab. The results of this study will therefore provide uni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Multiscale chemical engineering of functional metal halides' (SCALE-HALO), addressing dissemination and exploitation.

assistant: **Impact**

SCALE-HALO proposes a research program that will advance the development of highly luminescent molecular and solid-state compounds by focusing on the emerging, vast, and rather underexplored compositional and structural spaces comprised of metals and halogens, i.e., metal halides (MHs). SCALE-HALO is motivated by the eventual utility of MHs as versatile photonic sources in modern appliances (e.g., displays and lighting) and in future quantum technologies. The recent success of lead halide perovskites in optoelectronics inspires broader exploration of the chemistry and photophysics of MHs. The clear objective is to determine factors controlling the spectral widths and emission peak wavelengths, Stokes shifts, radiative lifetimes, and quantum efficiencies. In addition to the need to discover new chemically robust and nontoxic MH emitters, there is also a critical need to engineer material morphologies suitable for specific applications (e.g., thin films, nanocrystals, composites, etc.) Ensuring the thermal and environmental stabilities are especially important efforts. SCALE-HALO will therefore encompass the chemical engineering of MHs at the atomic scale (e.g., new compounds), nanoscale (e.g., synthesis of nanostructures and their surface chemistry), and mesoscale (e.g., nanostructure superlattices and composites). Furthermore, modern exploratory syntheses will be accelerated with automated high-throughput methods (e.g., robotics and microfluidics). The characterization toolbox for probing the local atomistic structure will be expanded with multinuclear NMR spectroscopy. The individual and collective optical properties of MH nanostructures and their periodic assemblies will be established and rationalized. Toward diverse real-world applications, first trials will be unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Understanding Emotional Actions' (EmotionalActions) under Horizon 2020.

assistant: **Objectives**

Emotions shape our personal lives and society at large. In Europe emotional disorders affect one in five people; it is the most chronic and second to most disabling health condition. The stakes to better understand our emotional behaviour are high; however there is still a lot to gain. Traditionally, emotions are thought to guide our behaviour either through fast instincts or deliberately selected actions. Current explanations of emotional health and disease frequently focus on one of these single components in isolation (or regard them as exclusive antagonists), but likely underestimate our emotional behaviour’s complexity and diversity.Here I will investigate a complementary account: I suggest that in humans optimal emotional behaviour arises not from these instinctual and deliberate action selection systems individually, but from their interaction, mediated in our brain by a likely uniquely human prefrontal control system. First, using an innovative task, behavioural profiling, and formal computational modelling I will determine the influence and interaction of these systems in emotional behaviour. Second, I will use concurrent neuroimaging (fMRI) and neurostimulation (tDCS), geared at the prefrontal control system and its connectivity with amygdala and parietal cortex, to investigate their causal mechanisms during emotional situations.This ambitious project combines my extensive experience in emotional behaviour with the world-leading expertise of University College London in computational neuroimaging and neurostimulation. These investigations are deliberately designed to both further our understanding of emotional behaviour and to initiate a path for improved treatment of emotional disorders in Europe. The computational modelling approach will elucidate hidden mec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Magnetic non-volatile Random Access Memory for SPACE with Serial interface' in the context of a Horizon 2020 call.

assistant: **Objectives**

Memories are critical components for space applications. They can be separated into three types: mass, cache and program memories. The latter permanently stores a program which can be executed as a MCU boot memory or FPGA configuration non-volatile memory (NVM). In space applications, the program memory is the one which requires the highest reliability, zero error tolerance, and the highest radiation hardness as it is directly related to the system power up. On the other side, as the requirements of system performance increased, integrated circuits (IC) are more and more dense. The recent space program memory requires higher speed and density. For example, the European rad-hard FPGA BRAVE NG-Medium requires at least a 13Mb configuration. The next generations NG-large, and NG-Ultra will require 128Mb and up to 512Mb high speed, low pin-count configuration memories.  Currently, for this critical memory, there is no European radiation hardened memory component available.MNEMOSYNE project aims to develop (design and prototype) the new generation of radiation hardened high density NVM with serial interface based on most-advance and matured European commercially available 22 nm FDSOI Magnetic RAM (MRAM) technology.Thanks to FDSOI semiconductor structure, this process naturally provides good radiation tolerance. In addition, MRAM technology is naturally SEU immune. Key innovations are:•The first European RHBD (radiation hardened by design) space NVM with density higher than 1Mb;•The first World Wide RHBD space NVM with density higher than 16Mb;•The first European embedded RHBD high performance space NVM IP core on process lower than 65nm;•The first new generation Spin-Transfer Torque (STT) MRAM for space application;•The first RHBD applied on 22nm FDSOI on both digital and ana
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Surviving the dry state: engineering a desiccation-tolerant mammalian cell', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Certain plants, animals and micro-organisms are able to dry out completely and yet remain viable, a phenomenon known as anhydrobiosis ( life without water ), or desiccation tolerance. This proposal addresses the molecular mechanisms responsible for desiccation tolerance and aims to confer these mechanisms on desiccation-sensitive mammalian cells, establishing a new field in biotechnology: a form of synthetic biology we have called anhydrobiotic engineering.  One feature of anhydrobiotic organisms is the production of many examples of highly hydrophilic proteins (or  hydrophilins ) in preparation for severe dehydration. Although data are limited, these hydrophilins are suggested to fulfil various roles in preserving homeostasis of the desiccating cell, including the maintenance of protein, nucleic acid and membrane structure. The proposed project will investigate the function of hydrophilins, engineer these and other elements as desiccation protection modules, and introduce modules into mammalian cell lines. By combining protection modules and using an iterative deployment strategy, we aim to achieve an engineered mammalian cell with high viability in the dried state.  Anhydrobiotic engineering will find applications in cell banking, e.g. of hybridoma collections, and cell-based technologies including tissue engineering. Principles established should be applicable to agriculture, where drought-resistant crops, or desiccation-tolerant biopesticides are envisaged.  The PI has a distinguished record of achievement in several disciplines in the life sciences and biotechnology, in both academia and industry. Publications in Nature, Science and other leading journals include contributions in human genomics, the molecular genetics of the immune system and inherited disease, the