RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mobility initiatives for local integration and sustainability' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The cities of Toulouse (France), Debrecen (Hungary) and Ljubljana (Slovenia), their public transport operators, the private sector and research institutions are committed to establish a European partnership for 'Sustainable Mobility Measures and Innovations in Transport' (SUMMIT).Aiming for radical strategies for clean urban transport, the political leaders of the three cities joined forces to create a new culture for clean mobility in European cities in the wider frame of sustainable development, broad participation of all relevant actors and particular care of social inclusion. The cities have developed a solidly packaged work programme which addresses all eight CIVITAS Policy Fields in an integrative approach.The highlights of policy areas are:- broadening the use of alternative fuels and clean vehicles through large-scale operation of clean vehicles for public transport (CNG, bio fuels);- emphasising on determining the optimum mix of alternative fuels, following EU objectives to migrate in long-term from bio-fuel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fusarium ear blight and mycotoxin control in europe's cereal crops' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The research discipline is molecular genetics and the studies involve interactions between pathogenic fungal species and cereal plant species. The projects will give each Fellow a thorough training in either wheat genomics or microbial genomics, proficiency in the use of numerous bioinformatics tools, the molecular skills necessary to prepare vector constructs for either plant or fungal transfonnation, and a thorough appreciation of how GM organisms are evaluated. Both Fellows will be trained in how to link specific gene expression profiles to critical aspects of biology. Through directed scientific reading and scientific team discussions, both Fellows will be able to recognize how this increased understanding of a host -pathogen interaction can be commercially exploited. In addition, the Fellows will gain knowledge and experience in a research area that is under funded in the academic community: Although knowledge on the molecular basis of plant defense and resistance to microbial attack is increasing most data comes from model pathosystems involving Arabidopsis These studies are currently of limited value to the solving of disease problems in cereal crops. There is a paucity of molecular knowledge on host-pathogen interactions controlled by race non-specific resistance mechanisms. Even fewer molecular groups study flower/ear/fruit-attacking pathogens, where the consequences of disease can affect end -user quality and product safety. Both Fellows research projects will identify many novel-underlying principles applicable to cereal attacking pathogens.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'COmpound 21 and MElatonin in CArdiovascular REmodeling' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Cardiovascular (CV) diseases are the major source of morbidity and mortality in the EU with annual costs of € 169 billion. The control of hypertension and prevention of left ventricular (LV) hypertrophy and fibrosis, which could interrupt the CV continuum, still remain insufficient world-wide. A substantial part of current therapies modulate the renin-angiotensin system (RAS) and decrease the unfavorable stimulation of angiotensin type 1 receptors (AT1R). Results of the host group indicate that many of AT1R effects are opposed by type 2 receptor (AT2R) activation. AT2R are up-regulated in several pathologies, making targeting of AT2R effective specifically in disease. The investigation of long-term effects of direct AT2R activation on hypertension and CV remodeling was allowed only recently by the discovery of AT2R agonist, compound 21. Fellows results suggest, that the pineal hormone and antioxidant, melatonin, prevents fibrosis and can be especially useful in combination with RAS modulation. We aim to investigate the effects of 5-week administration of compound 21, melatonin and their combination in L-NAME hypertensive rats on CV remodeling and relevant protein expression pattern. Advanced, interdisciplinary techniques from physiology to molecular biology will be implemented. The findings should indicate whether the exciting AT2R targeting is a promising approach to CV diseases and whether the use of a novel drug combination can preserve myocardial structural homogeneity. This project will yield important scientific and clinical implications and provide an outstanding training, guaranteed by excellent researcher in charge. Proposed training will unfold researcher’s creativity, networking and other complementary skills and promote his scientific maturity and independen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unraveling mechanisms of immunotherapy resistance through biomarker profiling in triple-negative breast cancer' under Horizon Europe.

assistant: **Concept**

Breast cancer remains a major public health issue, being the leading cause of cancer deaths among women in France, with around 58,459 new cases and 12,146 deaths reported in 2018. There are three main types: hormone receptor (HR)-positive (75-80% of cases), HER2-positive (15% of cases), and triple-negative breast cancer (TNBC) (15-20% of cases).Standard treatment involves surgery, radiotherapy, chemotherapy, hormone therapy for HR-positive cases, and targeted anti-HER2 therapy for HER2-positive cases. Recently, immunotherapies like pembrolizumab (an anti-PD1 antibody) have been approved for TNBC patients, in combination with chemotherapy. However, immune checkpoint inhibitors are associated with immune-related adverse events (irAEs) due to generalized lymphocyte activation, which can affect any tissue and even lead to death in severe cases.There is an urgent need to better understand the anti-tumor immune response to reduce toxicity, improve immuno-oncology strategies for TNBC, and broaden their application to other breast cancer types. Additionally, treatment resistance is a significant challenge, with unknown reasons limiting the number of patients achieving complete response.The proposed project aims to advance breast cancer immunotherapy by developing a comprehensive molecular approach to discover TNBC immunotherapy biomarkers of treatment resistance and irAE development, thank to the access to TNBC patient cohorts.Molecular characteristics and clonotype dynamics of T cells (CD8+, CD4+ Tconvs, and Tregs) at the single-cell level during anti-PD1 treatment, will be correlated with tumor transcriptomic data and clinical data. Analysis of an existing cohort of 83 TNBC patients treated with pembrolizumab and neoadjuvant chemotherapy will uncover aspects of the anti-tumor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Electronic Customer Relationship Management' (ECREM), addressing dissemination and exploitation.

assistant: **Impact**

Magic Software Enterprises and its partners would like to introduce to the European market a powerful new Electronic Customer Relationship Management (ECREM) System, to enhance the relationships between the supplier and its consumers. ECREM software system will comprise of Analytical and Operational subsystems, intends to automate services and business processing transactions in a personalised Web environment. It is intended to particularly suit for multinational businesses, operating in a competitive environment, dealing with large number of customers, and with substantial amounts of repetitive business. The system will give a secure, robust and scalable back-end solution to manage efficiently facilities like Call Centres and Customer Service Departments sing Computer Telephony Integration (CTI).The project contain a unique and innovative approach to perform a comprehensive research, followed by a working prototype ready for validations and trials.Objectives:EU project ECREM will address the following business goals:- Increase customer loyalty and satisfaction.- Conduct market targeting more cost-effectively.- Integrate customer services through the web.- Globalise customer services.- Enhance customer personalisation.- Personalize web pages and automate Personal Notification Services.- Increase productivity of the organisation's customer service facility.The Technical Objectives to achieve these goals are:- Automation of services and business processing transactions.- Real time multi-language system capability and regional regulatory.- Integrated Data Mining design and implementation to accomplish adequate Business Intelligence.- Utilise the capabilities of the web.- Customer data management as the key to driving personalisation and measuring success by value and shari
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Organic Nanomaterials for Electronics and Photonics: Design, Synthesis, Characterization, Processing, Fabrication and Applications' under Seventh Framework.

assistant: **Concept**

The call 4.2.2-1 “organic materials for electronics and photonics” is based on the observation that the limited availability of high-performance multi-functional materials is a roadblock to further industrial progress. To address the wide scope of the call, we have identified specific materials bottlenecks to the fields of electronics and photonics. They constitute the focal points of our project. One-P main objective is: “to invent, design, synthesize, characterize, process, and to supply the missing materials in the fields of organic electronics and photonics and to develop appropriate patterning methods for micro- and nano-structuring of these materials that can be up-scaled to roll-to-roll technologies”. The work plan is composed of five technical workpackages, each one addressing current materials challenges: 1) charge transport and injection, 2) detection and sensing, 3) light emission, 4) functional self-assembled monolayers, 5) continuous processing and technology. Computer-aided design of materials and the use of advanced characterization tools are transversal activities that are integrated in technical workpackages. The sixth workpackage is devoted to dissemination, exploitation, and management of intellectual properties that are essential for the project success. To carry out this multi-disciplinary project, a cross-sectorial consortium has been formed at the European level. It is composed of strong academic and industrial teams with necessary and complementary expertises to cover all scientific, technological and exploitation aspects. The project will generate fundamental knowledge and help to develop unprecedented technologies. They will have a positive impact on competitiveness of European industries, environment, job creation, health, security, safety, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Metabolites as immunomodulatory additives for biomaterials' (Met4Bone).

assistant: **Innovation**

The biomaterials are crucial for the surgical remediation of bone defects caused by various diseases e.g. osteoporosis and traumatic fractures. However, there are several risks associated with this treatment; first, the surgical procedure itself carries a potential risk of inflammation and bone infection, second, the bone replacement can fail requiring revision surgery. In fact, the host immune response to implanted materials and devices is the main factor that will determine a long-term functional outcome of the biomaterial mediated treatment. Therefore, the bone biomaterial ability to modulate the local immune environment for favorable treatment outcomes has to be considered. The usage of bioactive metabolites has emerged as one of the most novel and potent approach for immune response modulation. The incorporation of metabolites with immune regulatory properties seems an especially attractive option for biomaterials as it would ensure site-specific delivery system and allow modulation of the microenvironment. The goal of this project is to develop novel biomaterials with incorporated metabolites as a potentially effective and safe strategy to modulate local immune response towards favorable outcomes of surgical bone remediation. To achieve it, the recent concept of metabolomics with the state of the art biomaterial design and research will be combined in this project. This proposal includes the transfer of knowledge to the host institution and the training of the researcher in new techniques and skills. The multidisciplinary nature of the project is strong, combining materials science, biochemistry, and molecular biology. Results have the potential to pave the way for novel biomaterials significantly improving clinical outcomes for patients suffering from bone injuri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The role of Toll-Like Receptors  Signaling in Angiogenesis and its Potential Applications in Promoting Vascularization in Regenerative Medicine' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The creation of adequate tissue constructs and other therapeutic products in tissue engineering and regenerative medicine is a highly challenging task. Adequate vascularization of tissue engineering constructs is an important prerequisite, which could be promoted by allowing stem cells or progenitor cells to reach the site of injury/replacement for tissue repair. The development of new approaches leading to a fast and successful vascularization is therefore one of the most intensively studied subjects in tissue engineering and regenerative medicine. Our previous work has demonstrated that endothelial progenitor cells from peripheral blood or cord blood are a potential autologous cell source for cellular therapies aiming to enhance the neovascularization of tissue engineering constructs. However, in these in vitro angiogenesis studies, the effect of one important system present in vivo, the immune system, has not been taken account.Innate immunity plays a very important role in tissue engineering and regenerative medicine. Following biomaterial implantation the host reactions may include tissue injury, blood-material interactions, provisional matrix formation, acute inflammation, chronic inflammation, granulation tissue development, foreign body reaction, and fibrosis/fibrous capsule development.Innate immune recognition relies on a diverse set of germ line–encoded receptors, termed pattern recognition receptors (PRR), which recognize broad classes of molecular structures common to groups of microorganisms. Toll-like receptors (TLR) are one of the largest and best studied families of PRR. Several studies have linked the TLRs with angiogenesis in a variety of conditions. The final goal of this project is to understand the way that TLR signaling pathways affect angiogenesi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Airline TriAls of Environmental Green flIght maNAgement functions'.

assistant: **Innovation**

Aiming at developing systems which enable environmentally sustainable flight operations, SGO part of the Clean Sky is working on the implementation of three new operational concepts suitable of being implemented on board through future Flight Management functions.Based on promising results through Laboratory test, ATAEGINA project should contribute to evaluate those concepts on a real operational environment by involving an Airbus equipped airline to:- Analyze the new proposed Flight Management functions and their compatibility with actual operations- Assess the environmental performance of those new functions, in comparison with actual operations, throughout an operational test plan and corresponding statistical analysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'FEATHERS (FE / MALES AND THEIR SCRIBES): Authorship and the Mediation of Voices, c. 1558-1642', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

When we look at a text, we think we know who wrote it. Indeed, Paradise Lost was authored by John Milton; the warrant of execution for Mary, Queen of Scots by Elizabeth I. The writers of these texts, the pen wielders, however, were Deborah Milton, and W. Davidson with Burghley. Manuscript production was a collaborative or ‘socialised’ enterprise that often involved secretaries and scribes who physically wrote what the author dictated.Sometimes, however, they contributed rather more. Google, MS Word and even dictation software help us write emails – a traditional secretary silently corrects grammatical errors, suggests changes and even creates texts from notes ready for the employer’s authorising signature: the early modern scribe fulfilled some or all of these roles.To distinguish between authorial and scribal voices the project will analyse 3 distinct manuscript types: Historical letters, Legal documents, and Literary works. In doing so it will address 3 questions: who were these scribes; what was their role or function, and where did their influence end and their employer’s begin?Experiences of scribal publication differed along gender and class lines as while high-born men were drawn to it, women and the lower-born were mostly confined to it, rarely holding a pen themselves for reasons as diverse as seemliness and illiteracy. Impacting the fields of literature, cultural history, and digital humanities, this cutting edge project will forever change the way we think about early modern authorship, adding many texts to the canon by authors hitherto marginalised, such as women and the lower-born.The project will create a model applicable to multiple political periods and countries by concentrating on England between 1558 and 1642 (the beginning of Elizabeth I’s reign to t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'THE IMPACT OF TECHNOLOGICAL TRANSFORMATIONS ON THE DIGITAL GENERATION' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

DigiGen aims to develop significant knowledge about how children and young people use and are affected by technological transformations in their everyday lives. The project is organised into eight distinct work packages. It will make use of participatory methodologies that moves the focus from “research on” children and young people to a focus of “research with” children and young people as co-researchers, co-creators and co-designers. The goal of DigiGen is to understand why and how some children and young people benefit from ICT use while others seem to be impacted negatively. It takes as its focus children and young people (from 0-18 years of age), a group growing up today that is described as the digital generation (DigiGen). Through sustained engagement with the digital generation, the project will include the use of innovative quantitative and qualitative methods and in-depth case studies. The cross-disciplinary team of researchers will enhance cooperation between home, schools and the wider community to ensure safe and productive ways of using ICTs. In understanding the impact of technological transformations as they affect the digital generation, we identify a set of systems that are important in young people’s lives. These systems include a focus on family (the home), leisure, education and the wider community (civic participation). The outcome of the project will contribute to the development of explanatory models that will inform relevant stakeholders and practitioners on the long-term effects of ICT on child development and on practices that maximise risks, minimise risks and maximise benefits.


**Keywords:** Technological transformations, educational institutions, family, leisure time, civic participation, innovative research, participatory methodologies,