RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Special 3d-simulation system for fasteners industries' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The Fasteners industries are component suppliers mainly of the automotive industry, aircraft industry, aerospace industry and electronics industry. The design of the manufacturing processes is based largely on experience and scientific rules formulated in the past without knowledge of modern process technology and material properties. Often a suitable process design is found using a cost intensive trial and error approach. The finite element method (FEM) enables technologically optimal process designs and thus enables considerable cost savings of materials, tools and tests. At the same time it aids the introduction of new technological process designs for new materials and for new products. At present for 3D modelling this method is used only in scientific institutions or in large enterprises with their own research and development departments and usually by specialist employees. The main disadvantage in 3D modelling is the complex and difficult nature of Preand Postprocessing. The existing systems were originally designed with a general purpose character and they are therefore difficult to master and time consuming. For cold forming processes typical of fastener production tool surfaces and process conditions must be accurately described as part of the pre-processing system. Usually the description of tool surface is given by a mesh of triangular elements generated by general CAD systems. This tool description often results in a model of insufficient accuracy for the purposes of process simulation. The partners have therefore gathered to develop a 3D simulation tool for process modelling which fits the requirements specifically of the cold forming fastener industry. Special semi-intelligent Pre- and Postprocessing modules will be added to an existing 3D code. The tooli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Unmasking the dynamic influence of the hematopoietic niche as an oncogenic path to myeloid neoplasms evolution'.

assistant: **Concept**

Although oncogenic driver mutations are found in healthy tissues sometimes at a prenatal stage, they do not often result in overt cancer. This genotype – phenotype discrepancy warrens the search for extrinsic mechanisms of cancer development and maintenance, such as aging or exposition to specific environments. Using myeloid neoplasms as a cancer model, I aim here at dissecting the hematopoietic-niche partnership at the “pre-leukemic”, “leukemic” and “post-leukemic” stage to identify innovative therapeutic strategies to prevent acute myeloid leukemia (AML) development, maintenance and recurrence. To enable experimental modelling of the bone marrow niche at different disease stages, I collected longitudinal paired stromal and hematopoietic primary patient samples, and generated physiologically-relevant in vitro and in vivo humanized models. In this proposal, I will first apply large-scale pooled genetic screening approaches to gain insights into the role of the hematopoietic-niche cellular communication processes in leukemic transformation of “pre-leukemic” clonal myeloid conditions. In the second part of the proposal, I will combine cutting-edge spatial single-cell RNA sequencing technologies with functional genetic screening to dissect the “leukemic-niche” crosstalk and ultimately fuel the development of concomitant “seeds” and “soil” therapeutic strategies. Finally, I will design a functional single-cell screening approach allowing modulation of the “post-leukemic” niche, to open the road for novel maintenance treatment strategies re-establishing healthy hematopoietic stem cells fitness advantage to prevent relapse.Overall, the proposed research project provides a framework for defining and understanding the dynamic influence of the hematopoietic niche as an oncogenic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of a smart workflow based on high resolution mass spectrometry for the assessment of the performance of wastewater treatment technologies' (SMART-WORKFLOW) targeting Horizon 2020.

assistant: **Abstract**

Discharges from wastewater treatment plants (WWTPs) are one of the major sources of aquatic pollution. The increased detection of a wide range of organic micropollutants in the aquatic environment shows the limitations of conventional WWTPs (developed and designed to protect natural aquatic systems and water resources mainly by removing loads of carbon, nitrogen and phosphorous) in removing these compounds. Therefore, advances in WWTP technologies are crucial to limit the burden of WW-originated contaminants. To date, one of the main challenges is to appropriately evaluate the different treatment technologies regarding their potential to minimize the toxicological risks for biota and human health. The main objective of SMART-WORKFLOW is to integrate the last advances in high resolution mass spectrometry (HRMS) and statistical analysis of data to develop and optimize a smart methodology (workflow) for the assessment of the overall quality of wastewater treatment. Treatments that will be evaluated include the ones (i) based only on physical processes (e.g. membrane filtration or carbon adsorption) where there is no change in the chemical identity of the pollutants and (ii) with changes in the identity of the pollutants due to chemical reactions, including biological treatments or advanced treatments based on oxidation processes (AOPs). The generated workflow is understood as a procedural sequence for data acquisition, data processing and data mining and it will be applicable to both already-known and new wastewater treatments, providing a rapid assessment on its performance regarding the removal of polar organic compounds and generated transformation products (TPs). The present project aims to produce a substantial impact on the field of water research, one of the Europe’
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Embedded fault tolerant supercomputing' to be submitted under Fourth Framework.

assistant: **Abstract**

The major objective of the project is to provide a framework for the implementation of fault tolerance in embedded supercomputing applications. This framework will provide a flexible, standard approach for programmers making embedded supercomputing applications more dependable. This approach will shorten the time to market, facilitate software development, maintenance and upgrading, and reduce dependence on specific hardware.Fault-tolerant functions will be accessible to application developers through the high-level API of the fault-tolerance library which extends Embedded PARIX (EPX). This will hide hardware-dependent features from the application programmer, guaranteeing that the application can be ported to standard hardware platforms and run-time kernels. The target architecture of the project is an MIMD, homogeneous, distributed-memory, message-passing, multi-processor system. Work will be performed on a Parsytec embedded system, based on the PowerPC microprocessor. The operating system will be EPX and the programming language will be ANSI C / C++. Important industrial end-user applications of embedded parallel computing will drive the requirements and demonstrate the results. The applications include mail sorting (AEG) and control of high-voltage substations (ENEL).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Label-free fluorescence lifetime analysis for the screening of nanoencapsulated drugs' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Nanomedicine has the potential to revolutionize healthcare by enabling targeted drug delivery, reducing side effects, and improving treatment efficacy. However, the field faces a critical bottleneck: the lack of efficient, non-invasive analytical tools to assess drug encapsulation, stability, and release dynamics in nanoformulations. Current techniques rely on destructive, time-consuming methods, limiting their applicability in formulation development and quality control.enLIGHT introduces a breakthrough approach—a patented, label-free fluorescence lifetime-based screening technology that provides real-time, quantitative insights into the physical state of encapsulated drugs. By leveraging exploitation of the intrinsic luminescence of drugs and a phasor-based, fit-free and purely graphical analysis, enLIGHT eliminates the need for fluorescent labeling or complex sample preparation, offering a rapid, cost-effective, and non-destructive alternative to traditional characterization techniques.Validated in laboratory settings, enLIGHT has already revealed unexpected drug behaviors in FDA-approved nanomedicines, demonstrating its ability to uncover hidden formulation instabilities. This Proof of Concept project aims to move enLIGHT from a complex lab setup to a compact, user-friendly device for pharmaceutical and research laboratories. By refining the prototype and validating its performance across diverse nanoformulations, the project will establish enLIGHT as an indispensable tool in nanomedicine analytics.With its potential to enhance drug development pipelines, reduce formulation failures, and streamline regulatory approval processes, enLIGHT represents a transformative innovation for the pharmaceutical industry—ensuring more stable, effective, and safer nanomedicines for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Kernel-based ARchitecture for safetY-critical cONtrol' (Karyon).

assistant: **Innovation**

The use of autonomous mobile systems as unmanned aerial vehicles (UAVs) or smart cars are desirable for example for environmental surveillance like the monitoring of ash clouds emitted by volcano eruptions as seen in 2010. Also increasing traffic throughput by improving vehicle density in roads by smart cars co-ordinating their behaviours without driver involvement will be a means to maintain mobility without the need to build new traffic infrastructures. Sharing the same air- or ground space these systems need to communicate and cooperate with other systems in their environment. However, so far, these systems are not allowed to operate in the public air space or on public roads because the risk of causing severe damage cannot be excluded with sufficient certainty.KARYON addresses the problem of finding robust cruising strategies for vehicles. They are based on information from other vehicles, an estimation of the global system state, and how confident one is about this estimation. KARYON will define a system architecture that is based on a small local safety kernel that will prevent dangerous behaviour. Because this is a very small subsystem compared to the overall complex control system, its predictability can be justified. This is essential for guaranteeing overall safety along a set of safety rules. KARYON will further investigate the relevant fault detection concepts, particularly for the sensor systems, needed to show fulfilment of dependability attributes and argue about safety according to safety standards. Simulation and mixed reality techniques will be developed to validate the approach. KARYON will integrate concepts in advanced event dissemination middleware and in improved simulation and fault-injection tools for assessing the behaviour of autonomous, mobil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Using CARDIac simulations to run in-silicO clinical TRIALS' to be submitted under Horizon Europe.

assistant: **Abstract**

Clinical trials are a key tool for advancing medical knowledge, but they consist of a long and costly process entailing the recruitment of a representative cohort of participants to properly account for the population statistical variability. Computational engineering is a promising approach to gain more insight into patients' cardiac pathologies and to test innovative medical devices before running conclusive in-vivo experiments on animals or medical trials on humans. This technological breakthrough, however, is limited by some technical and epistemic challenges: (i) the reliability of cardiovascular computational models depends on the accurate solution of the hemodynamics coupled with the deforming biologic tissues; (ii) the resulting multi-physics solver requires an immense computational power and long time-to-results; (iii) a great variability among individuals exists, thus calling for a statistical approach. For the first time I will accomplish and employ a computational platform for determining the outcome of pathologies or devices implantation by combining my GPU-accelerated multi-physics solver for the accurate solution of cardiac dynamics with an uncertainty quantification analysis to account for the individuals variability. The input parameters of the computational model will be treated as aleatory variables, whose probability distribution function will be obtained using three-dimensional datasets of cardiac configurations available to the PI's group and acquired in-vivo by the clinical members involved in the project. Simulation campaigns (rather than a single simulation) will be then run in order to sweep the uncertain input distributions and obtain the synthetic population response in the case of selected pathologies like myocardial infarction and the optim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'L-form bacteria, biotechnology and disease' (ELFBAD), addressing dissemination and exploitation.

assistant: **Impact**

Despite the clear importance and multiple functions of the bacterial cell wall, many bacteria appearto be able to switch into a cell wall deficient or “L-form” state. L-forms are very heterogeneous insize and shape and generally require osmotic stabilisers, such as 0.5 M sucrose, for viability.However, by lacking the requirement for a cell wall, L-forms are completely resistant to commoncell wall antibiotics, such as β-lactams, and they are probably protected from some elements ofinnate immune recognition. L-forms are therefore of potential interest in relation to their possibleinvolvement in human disease. They have often been reported in clinical specimens obtained frompatients with recurrent or persistent infections or on long term prophylaxis with β-lactam antibiotics.Unfortunately, until recently, most of the work on L-forms had been done in the pre-molecular era,when it was difficult to characterise the L-forms and particularly to identify their origins andrelationship with other resident pathogenic bacteria. Recently, several labs have revisited the L-formissue and started to apply modern molecular and cell biological methods. The proposal is divided into three Themes:• Improve our understanding of key features of the L-forms of our best characterised model system, B. subtilis, including both basic science and possible biotechnological applications. • Extend our analysis of basic L-form biology into several diverse bacterial systems, of relevance to both biotechnology and infectious disease. • Explore in detail the possible clinical relevance of L-forms, aiming to identify specific clinical situations in which they are relevant or, at least, to establish model systems in which the interactions between L-form and mammalian systems can be studied.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Conditions and duration of High tempeRature metamOrphism in large hot orogeNs assessed through petrochronolOgy : insights from Grenville TECtonics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Deciphering duration and conditions of metamorphism in orogenic systems is crucial to understand large-scale tectonic processes. In the last decades, the development of thermodynamic modeling and instrumental advances in elemental and isotopic analysis have open new avenues to unravel the Pressure-Temperature-time paths of rocks, to assess the rates and duration of large-scale orogenic processes. However, orogenic roots in Large Hot Orogens (LHOs) that can attain and maintain temperatures higher than 800°C over several tens of million years still challenge our ability to decode the timing of events, and our understanding of tectonic processes and crustal evolution.CHRONOTEC proposes an innovative multi-approach strategy using state-of-the-art instrumentation, to link the chronometers garnet and zircon through their isotopic (U-Pb in zircon; Lu-Hf and Sm-Nd in garnet, O in garnet and zircon) and elemental (trace element) record, combined to a detailed petrological investigation, including phase diagram modeling. This approach will be systematically used on selected mafic granulites from distinct crustal levels (mid and high pressure) of the Central Grenville Province in Canada, one of the first LHOs on Earth. CHRONOTEC will bring a complete portfolio of new fundamental results from natural samples to assess the link between zircon and garnet in high-T mafic rocks. Integration of the results will provide an unparalleled framework to assess the metamorphic evolution of the central Grenville province, and by comparison to other LHOs, will refine our understanding of large-scale high-T orogenic processes.


**Keywords:** Petrochronology, REE, radiogenic isotopes, stable isotopes, garnet, zircon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'FULLY AUTOMATED ROBOTIC SYSTEM for ALL PROCESS STEPS of the HAIR TRANSPLANTATION SURGERY PROCEDURES (FUE-Robotic System)' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

FULLY AUTOMATED ROBOTIC SYSTEM for ALL PROCESS STEPS of the HAIR TRANSPLANTATION SURGERYPROCEDURES (FUE-Robotic System)We introduce a groundbreaking innovation which is a patented Robotic System into Hair Treatment Field.Hair transplantation is used to treat hair loss, a condition that affects more than 50 million men and 30 million women in theworld. The total market size for hair transplantation surgery has increased 28% since 2012, or from 1.9 billion EURO (€) in2012 to 2.5 billion EURO (€) in 2015*. At almost 1.050.000 Hair Transplantation Procedures are performed annuallyworldwide*. It is a fantastic opportunity to reach an Untapped Market.The submitted proposal relates to a method and apparatus for hair transplantation and in particular a method and apparatusfor FUE Method Hair Transplantation which utilizes SCS (Spherical Coordinate System) Mechanism, Gripper and 3D DataProcessing Software.Our Patented FUE Robotics System is the First and Only Robotic Hair Transplant System to safely introduce completing thewhole Process Steps of the FUE Hair Restoration Surgery Procedure without any Human Error Factor.Furthermore, The FUE Robotics System can reduce up to 85-90 % of surgery time period when compared to manual FUEtechniques and currently being developed other Robotic Systems in the market in the USA. It provides The Best Quality -Quantity - Price Ratio of all available hair transplantation methods. Other hair transplantation techniques cannot offer thesehighly sophisticated technological advancements.*Source; The International Society of Hair Restoration Surgery (ISHRS), 2015 Practice Census.This Proposal was submitted for another Work Programme Topic on the previous Cut-Off Day and ESR Total Score: 13,78but it was not provided because of the Limited Budget in SME