RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Targeted anti-cd40 monoclonal antibodies for treatment of multiple sclerosis'.

assistant: **Innovation**

To generate a high affinity anti-CD40 antibody/transferrin molecule (CD40-Mab/Tf) with improved access to the central nervous system (CNS) for immunotherapy of multiple sclerosis (MS) patients.To determine access of the CD40-Mab/Tf to the CNS of healthy and EAE (experimental autoimmune encephalomyelitis) rodents.To determine access of CD40-Mab/Tf to the CNS of healthy and EAE marmosets.To demonstrate feasibility of therapy with CD40-Mab/Tf in chronic relapsing EAE in marmoset monkeys and identification of effector mechanisms. In Europe more than 200,000 people suffer from multiple sclerosis (MS) a severe neurological autoimmune disease for which at present time no adequate therapy exists. This project aims to develop a novel immunotherapy for MS based on the modulation of antigen-specific activated T cells that infiltrate the central nervous system (CNS), provoking disease exacerbations through as yet unidentified mechanisms. The interaction of CD40 ligand (CD40L, exclusively expressed on activated T lymphocytes), with the CD40 molecule (expressed on antigen presenting cells) has recently been identified as a novel and accessible target for immunotherapy of MS. During exacerbations of MS, the CD40 molecule is highly upregulated on endothelial cells and mononuclear cells present in perivascular infiltrates. CD40L-CD40 interactions can activate a number of pathological effector mechanisms contributing to the inflammatory process of MS. A crucial role for these molecules was recently confirmed by showing that monoclonal antibodies blocking the CD40L-CD40 interaction effectively reduce disease severity in mice suffering from experimental autoimmune encephalomyelitis (EAE, an acute MS-like disease). This project aims to generate prototype high affinity anti-human CD40 antibo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'C53 and Ufmylation Regulation In Endoplasmic Reticulum-Autophagy (ER-phagy)' under Horizon 2020.

assistant: **Concept**

Autophagy is a highly selective cellular quality control pathway. Selective removal of autophagic cargo are mediated by cargo receptors that contain cargo binding domains and ATG8 interacting motifs to bridge the cargo with autophagosomes. Although cargo receptors are the key players linking autophagy to cellular quality control, most of them are still waiting to be uncovered in plants. Identification and characterization of novel cargo receptors will pave the way for future translational studies that aim to enhance stress tolerance in crop species.The host lab recently identified an Endoplasmic reticulum (ER) autophagy receptor C53, that interacts with ATG8 via non-canonical shuffled ATG8 interacting motif. Besides, C53 is regulated by an enigmatic posttranslational modification called ufmylation through binding to another ubiquitin-like protein UFM1. Interestingly, ATG8-UFM1 interaction is mutually exclusive. However, the structural basis of C53-ATG8 or C53-UFM1 interaction are currently unknown. Also, the physiological roles of ufmylation and the ufmylated protein substrates have not been studied in plants.In this proposal, I aim to structurally and genetically characterize C53-ATG8 and C53-UFM1 interaction. In parallel, using proteomics, I will determine the ufmylome, i.e., ufmylated protein catalogue in plants for the first time. Finally, I will move beyond model species Arabidopsis and establish autophagy and ufmylation studies in rice. Altogether, my studies will further our understanding of a novel ER quality control pathway in model plant species and beyond.I will work at the Gregor Mendel Institute (GMI), Vienna BioCenter (VBC) in the lab of Yasin Dagdas. VBC is one of the largest life sciences hubs in Europe. It has a dynamic postdoc community, with structure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Quantum-Optic Silicon as a Commodity: Extending the Trust Continuum till the Edge of ICT Networks'.

assistant: **Innovation**

The rapid rise of quantum computation has raised concerns about conventional encryption methods. In response to this emerging threat, quantum key distribution (QKD) offers an information-theoretically secure key exchange. However, its complexity currently hinders its widespread adoption.QOSiLICIOUS introduces a disruptive “commodity” approach, integrating every element of quantum random number generation (QRNG) and QKD monolithically on silicon. This results in ultra-compact implementations with clear photonic/microelectronic co-integration strategy and excellent cost credentials allowing us to address new QKD markets. A pixel-size (0.01 mm²) QRNG will be realized in 0.18-µm CMOS, including a multi-dot silicon light emitting diode surrounded by a ring-shaped single-photon avalanche detector (SPAD) with co-integrated active quenching. Its true random numbers will feed a QKD transmitter developed on a silicon-photonic BiCMOS platform on a footprint of no more than 1 mm². Simplicity is ensured through a novel GeSi light emitter sourcing a BB84 polarization state encoder. This yields an all-silicon solution free from the burden of complex and costly III-V / silicon hetero-integration. The efforts on QOSiLICIOUS’ QKD transmitter are complemented by surface-normal GeSi SPAD technology for 1550-nm operation at detection efficiencies of 50% under Peltier cooling. The GeSi SPAD will be transferred to the waveguide-based silicon-photonic platform to further yield an integrated QKD receiver including BB84 state analysis.The applicability of QOSiLICIOUS’ technology to commodity segments will be evaluated in techno-economic challenging scenarios (i) intra-datacenter interconnects, (ii) access and 6G networks and (iii) mobile applications with a close-proximity free-space optical key
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Glycans array fingerprints for the study of synbiotics' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

A growing awareness of the relationship between diet and health has led to an increasing demand for food products that are able to enhance health, as well as provide basic nutrition. Synbiotics are functional foods that combine probiotics (living microorganisms) and their substrates - prebiotics. Synbiotics demonstrate synergistic health benefits on the consumer. Synbiotics' mode of action is poorly understood. Even so, it is suggested that synbiotics have antimicrobial, anticarcinogenic, immunomodulatory, antidiarrheal, antiallergenic, and other activities. Therefore, scientific documentation is of major importance for the credibility of the synbiotic products. Glycans play an important part in human nutrition; these include glycoconjugate molecules that are part of food ingredients and secreted glycans from microorganisms in food fermentation.The issue of glycan analysis technology is repeatedly mentioned as key to the development of safer and better food. As the new head of biochemistry in NutriCognia, I will combine the company technology with the expertise I acquired in the USA to make use of synbiotics' glycan composition as a scientific tool for the characterization and monitoring of synbiotic aspects. Our approach to glycan analysis is based on lectin glycan interactions: glycoanalysis is performed by binding the intact glycoprotein to a lectin array (CarboDeep) and identification by specifically labelled lectin probes. CarboDeep presents a unique approach, that enables efficient, precise, qualitative, and quantitative methods for the study of synbiotics.We propose to:(1) optimise CarboDeep technology for the synbiotics field;(2) develop synbiotic glyco-fingerprinting application, using the synbiotics' glycans biochip; and (3) develop a biochip with higher speci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Training and Innovation in Reliable and Efficient Chip Design for Edge AI' (TIRAMISU), addressing dissemination and exploitation.

assistant: **Impact**

Artificial intelligence is increasingly being brought to the source of data, thus establishing the Edge AI concept. Edge AI is gaining momentum across various industries and services by public authorities and enables new applications requiring high performance, ultra-low latency with high bandwidth, efficient power use, and intelligence beyond regular computing. Its strategic importance is emphasised through the EU Chips Act monetary investments in the EU semiconductor supply chain, highlighting the urgent need for a qualified workforce. The advancements in Edge AI applications face critical research and engineering challenges related to limited computing and energy resources of the edge devices, limitations of the existing AI algorithms and their insufficient fit. Also, the related rapid technological advancements, market dynamics, interdisciplinarity, and regulatory uncertainty set a unique challenge for the valorisation and management of Edge-AI innovations. The general research objective of TIRAMISU is a practical methodology for reliable and energy-efficient Edge AI hardware backbone design and innovation management.The action will provide strong interdisciplinary training for future European engineers and researchers driving the innovation for reliable and energy-efficient Edge AI chips. The consortium is strategically designed to foster cross-disciplinary synergies, by seamlessly integrating innovation management research with the technical aspects of Edge AI design. The non-academic sector is represented by a European flagship R&D hub for nanoelectronics - IMEC, a global leader in industrial electronics and the largest semiconductor manufacturer in Germany - Infineon, a trusted automotive solutions provider - PUNCH, the worldwide leader in EDA tools development
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'State Agents on Trial: Hierarchies of State Criminality in Israel and France', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Since WWII, global politics has developed a heightened sensitivity to state violence. Although this sensitivity contributed to a reduction in state violence, it also constructed an economy of state criminality that situates sex crimes as the worst atrocity while normalising other forms of violence. This logic is further exacerbated when state security agents (SSAs) stand trial for crimes committed during service. These trials require the public to come to terms with the cost of security and renegotiate the boundaries between legitimate and illegitimate state violence. Studying SSAs’ trials as sites of contention over the state’s legitimate use of violence, I will explore: (1) What hierarchies are at work in shaping conceptions and reactions to state criminality? (2) What do these hierarchies teach us about social and political tolerance of state violence? and (3) Which political, social, and moral factors are at work in transforming hierarchies of state criminality? Conducting qualitative research based on archival work, I will explore how legal-normative infrastructures facilitate hierarchies of state crime in Israel and France from WWII to the end of the 20th century. By studying SSAs’ trials in these sites, the project will develop a model to assess hierarchies of state criminality based on three categories of felonies: crimes against body and life and property and sex crimes. I hypothesise that a different hierarchy is at play when SSAs commit such felonies compared to ordinary citizens. When SSAs are the perpetrators, I expect to find that property and sex crimes are judged more harshly than crimes against life and body that can be justified as a security necessity. If so, it is essential to design policies that break down these hierarchies, treating state criminal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovative espresso machine with new water heating and boiler design to improve efficiency and coffee quality' (ESSENCE).

assistant: **Innovation**

While it may sound strange considering how often coffee is consumed around the world, current professional espresso machines on the market are highly energy inefficient and struggle to consistently achieve and maintain the desired coffee taste quality that people in the industry refer to as “the god shot”. Realizing this market opportunity, an engineering automation company, Eurek SRL, and coffee machine manufacturer, 8B, have partnered to design a new machine that helps bars, restaurants and coffee shops save 50% of their electricity costs while also ensuring customers are served a delicious cup of coffee at any time of day.There have been significant improvements in control technologies that operate coffee machines but the basic internal construction and process of making espresso has changed very little. A coffee machine utilized in a commercial environment must be left switched on 24 hours a day to ensure that the hot water temperature is maintained. This leads to electricity costs that can exceed €7,000 per year.Our innovative design utilizes a modular approach that takes advantage of heating exchange technology to half electricity costs while also ensuring a premium quality coffee brew. New coffee machine designs have so far been unable to achieve this combination.Our new technology therefore has the potential to completely revolutionize the Espresso Coffee Machine industry, which is worth approximately €536 million in Europe alone with over 180,000 espresso machines sold annually. We expect our machine to generate revenues of €8 million by 2022, resulting in profits of €3.35 million that will be split between our two companies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High-Performance Advanced Methods and Experimental Investigations for the Safety Evaluation of Generic Small Modular Reactors' (McSAFER).

assistant: **Innovation**

The main objective of the McSAFER project is the advancement of the safety research for Small Modular Reactors (SMR) by combining dedicated experimental investigations and numerical simulations. Experiments will be performed on existing European thermal hydraulic test facilities to investigate SMR-specific safety-relevant phenomena (subcooled boiling, critical heat flux). The main objective of the McSAFER project is the advancement of the safety research for Small Modular Reactors (SMR) by combining dedicated experimental investigations and numerical simulations. Experiments will be performed on existing European thermal hydraulic test facilities to investigate SMR-specific safety-relevant phenomena (subcooled boiling, critical heat flux, transition from forced to natural circulation) with the goal providing corresponding data on code validation. Advanced computational tools developed and partly validated in the European projects NURESAFE, HPMC and McSAFE, will be used to conduct the neutron physical, thermal hydraulic and thermo-mechanic analysis of the reactor core of different SMR design. In the next step, multidimensional and multiscale methods will be applied to the analysis of the processes inside the reactor pressure vessel. Finally, different numerical tools (conventional, low order and high fidelity) will be applied to demonstrate the inherent safety features of an SMR-core as well as how the SMR-designs under investigation assure the safety function of core sub-criticality and core coolability under postulated design-basis-accident-conditions. The project is a planned as a research and innovation action. Despite the concentration on SMR, the methodology is fully transferable to LWR of Gen-II and -III as well as to Gen-IV reactors due to the versatility of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Subjectivity and Selfhood in the Arabic and Latin Traditions'.

assistant: **Innovation**

The overall aim of the SSALT project is to throw light on the incubation of modern notions of the self and moral agency in the thought of the ancient world, their adoption and adaptation in the European and Arabic middle ages, and finally their transformation in the early modern period. This aim is approached through the twin paths of Arabic and Latin thought, both of which were in equal measure heir to the legacies of Greek rationalism and Hebrew monotheism. While most of the progress made so far in the scholarship has concentrated on Latin scholasticism, a more equally weighted investigation between the Arabic and Latin traditions can not only serve to bring to light much material that is of contemporary philosophical and ethical interest, but will also bring about a deeper understanding and appreciation of the Greek and Hebrew notions of selfhood and moral agency that form the bedrock of our culture. Once we begin to understand the similarities as well as the differences between the various thinkers frequently cited in the discussions (Aristotle and Descartes; Augustine and al-Ghazali; Avicenna and Aquinas), we can begin to discern what the theoretical implications are of committing to a certain philosophical viewpoint regarding human subjectivity and agency. Plainly, the importance of these findings reaches beyond the merely academic.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'A multiscale approach to unsaturated flow in porous media with Preisach hysteresis'.

assistant: **Concept**

Experimental evidence indicates that fluid filtration through unsaturated porous media exhibits a hysteretic behavior, originating at a microscopic level from surface tension at the point of contact between water and air in the pores. As a result, the pressure-saturation constitutive relation turns out to be of hysteresis type, accurately described with the Preisach operator by a thorough fitting procedure.The main objective of the MulPHys project is to expand the knowledge about Preisach hysteresis for fluid filtration and build new mathematical models for unsaturated porous media, employing a multiscale approach.The suitability of the Preisach operator in describing the hysteretic behavior of unsaturated porous solids sparked an intense research effort in the community of experts in PDEs with hysteresis, with the goal of including the Preisach operator in mathematical models. In these endeavors, the presence of a microstructure was neglected, with the approach being directly macroscopic. Another branch of research has considered porous media as objects with a microstructure, and has derived the macroscopic description of fluid flow from local behavior. In this body of research, however, porous media are often assumed to be completely saturated so that no hysteresis can occur.With MulPHys, we will fill the gap between these two research areas, employing homogenization techniques to provide a justification of the Preisach operator as the correct tool for describing filtration. Particular attention will be paid to including gravity effects and understanding solid-liquid interactions at the microscopic level. Numerical simulations and experimental data will be instrumental in achieving these objectives.Potential applications in the preservation of historic buildings are f