RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'ASAS Thematic Network 2' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The ASAS Thematic Network II is a Co-ordination Action organised within European Commission 6th Framework Programme on Aeronautics and Space. The project is an Open Upstream Research activity for new generation ATM supported by Advanced Airborne System A pplications. The main objective of the ASAS Thematic Network II is to accelerate the application of ASAS/ADS-B operations in the European Airspace taking into account global applicability in order to increase airspace capacity and safety. The ASAS-TN2 b uilds on the experience of the ASAS Thematic Network project (ASAS-TN). The ASAS-TN is a two-year project (11/2002 - 11/2004) that is primarily a communication activity sponsored by the EC DG Research. The ASAS-TN delivered 3 successful workshops (Rome, 04/2003, Malmö, 10/2003 and Toulouse, 04/2004). The project will conclude with a seminar in Brighton in October 2004. The ASAS-TN Library is also a key feature of the Thematic Network. The ASAS-TN has been very successful and has attracted more members than initially expected. ASAS-TN2 is a continuation of this fruitful exchange among the R&D community, the ATM stakeholders and the industry. The ASAS-TN2 is innovative in several areas: - It concentrates information related to ASAS/ADS-B applicatio ns; - It is getting air-oriented or ground-oriented people working more closely; - It involves all key players; - It creates forums for communication, discussion, harmonisation and dissemination on ASAS/ADS-B issues; and - It creates a review group to develop guidance and recommendations. The main ASAS-TN2 outputs concern the sharing of current knowledge on ASAS/ADS-B between all stakeholders and in recommendations for future activities required to reach the operational use of ASAS/ADS-B applications. It is expected that these r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Reversible causally-consistent debugging of concurrent programs' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Modern computing devices execute complex software to provide every-day services and applications. The development of such software is challenging, time consuming and costly. It involves writing a program code, testing it and debugging it, namely finding an error in the code and correcting it. It is estimated that debugging costs an estimated 312 billion USD a year. The most successful commercial debugging tools are reversible debuggers. They allow the users to undo an execution of a faulty program, to find and correct errors, and then to run the corrected code forwards again. UndoDB by Undo Software is the top reversible debugger currently on the market. However, even the best reversible debuggers are not suited very well to debugging of concurrent programs. Moreover, it is not universally agreed yet how to reverse the code of concurrent or distributed software. This project aims at addressing these shortcomings by exploiting the promising notion of causally-consistent reversibility as the basis for reversible debugging tools. Novel formal models and new techniques for recording, analysis and replay of concurrent programs will be created. An execution engine for the shared-memory and message-passing styles of programs will be developed in a close collaboration with Undo Software and Erlang Solutions, the leading software companies. The scientific outcomes will be turned into an experimental prototype software, called Reversible CAusally-consistent DEbugger (RCADE), which will extend and enhance commercial debugging tools, especially for concurrency.The Fellow will undertake a world-class programme of research, industrial and academic training and collaboration. He will obtain formal lecturer qualification and deliver an undergraduate module. The knowledge and experience
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Elucidating the Role of Phosphorylation by Polo-like kinases in Modulating Alpha-Synuclein Aggregation and Toxicity in Parkinson's disease and Related Disorders' (2007-2013).

assistant: **Concept**

Increasing evidence suggest that alpha-synuclein (a-syn) phosphorylation plays an important role in the regulation of a-syn aggregation, Lewy Bodies (LBs) formation and neurotoxicity in Parkinson’s disease (PD) and related synucleopathies. However, the exact kinase(s) responsible for phosphorylating a-syn and the relationships between phosphorylation, a-syn fibrillogenesis, LB formation and cell death have not been fully elucidated. Preliminary data in our Laboratory have pointed out a Polo-Like Kinase family (Plks) as an interesting candidate for a-syn phosphorylation and modulating protein aggregation. To determine the relationship between the phosphorylation of a-syn by Plk family, protein aggregation and neurodegeneration, we plan to use an integrative approach combining in vitro and in vivo approaches. In the in vitro part, we seek to elucidate the role of phosphorylation by Plks in modulating a-syn aggregation in vitro and in primary cell culture. In the in vivo part, we plan to study the possible co-localization of Plks and phosphorylated and unphosphorylated a-syn in LBs inclusions in the brain of parkinsonians patients and animal models of PD. We also seek to evaluate the biochemical and functional consequences of co-delivering Plks and various modified forms of a-syn directly to the rodent brain. This proposal will give us the opportunity to better understand functional consequences of a-syn phosphorylation and mechanisms by which it contributes to neurotoxicity. That will allow us to identify new therapeutic targets of synucleopathies treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Novel targeted intervention to prevent brain aneurysm rupture' (INTERRUPT).

assistant: **Concept**

In the European Union, an estimated 15 million individuals harbour unruptured intracranial aneurysms (IAs), each at constant risk of rupture and subsequent subarachnoid haemorrhage (SAH). The imminent threat of IA rupture remains a significant clinical challenge, further exacerbated by the absence of safe and efficacious non-invasive treatments, mainly due to gaps in understanding the underlying mechanisms. Notably, intrasaccular clot formation is a prevalent feature of both ruptured and unruptured IAs, with activated platelets facilitating leukocyte recruitment. We hypothesize that platelets play a pivotal role in the development and rupture of IAs. We have identified a platelet receptor as a critical factor in IA rupture, based on compelling data from a preclinical mouse model. The goal of our ERC-POC project is to investigate and establish pharmacological inhibition of this platelet receptor as a groundbreaking therapeutic strategy for preventing IA rupture. To achieve this, we have designed a comprehensive, interdisciplinary approach encompassing a preclinical model and computational fluid dynamics applied to 3D aneurysm-like vessels. Our objectives are to validate the efficacy of inhibiting this platelet receptor in preventing IA rupture in mice and to thoroughly examine the impact of a receptor inhibitor on platelet function under dynamic conditions that mimic aneurysmal environments. Ultimately, our project aims to establish the clinical proof of targeting this platelet receptor with a leading compound to prevent IA rupture and significantly reduce the risk of SAH. By doing so, we aspire to alleviate the societal burden of intracranial aneurysms, offering a pioneering therapeutic framework for the management of unruptured IA.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fundamental biological adaptations underlying persister formation and multi-stress tolerance in Mycobacterium abscessus and their impact on host-pathogen interactions' to be submitted under Horizon Europe.

assistant: **Abstract**

The rapid spread of bacterial antimicrobial resistance (AMR) poses a major global health threat, leading to treatment failures. Beyond resistance, bacteria employ also other strategies to counteract antibiotics. Persisters represent a bacterial subpopulation that can survive transient exposure to different stresses, such as nutrient depletion, low pH or the presence of antibiotics. Increasing evidence suggests clinical importance of persister formation, since their ability to regrow after termination of antibiotic treatment is a cause for prolonged and relapsing course of many bacterial infections. Formation of persisters also accelerates the emergence of antibiotic resistance, worsening the problem of bacterial AMR. Recent research indicates that mechanisms involved in persister formation may also enhance the overall adaptability of bacteria to antibiotics and stresses imposed by host immune system. Targeting these dual mechanisms could represent a unique two-pronged strategy to improve treatment efficiency, preventing resistance development and decreasing bacterial survival within the host. However, our understanding of these mechanisms is very limited. Combining microbiology, molecular biology and infection models, together with cutting-edge techniques such as metabolomics and transcriptomics, I propose to identify key biological adaptations underlying the formation of bacterial persisters and to explore their impact on host-pathogen interactions and infection outcomes. As an emerging pathogen known for its high antibiotic resistance and ability to endure harsh conditions during infection, I selected Mycobacterium abscessus (Mabs) as a clinically relevant model for this study. Discovery of such adaptations can lead to the development of innovative treatments tackling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Energy Transitions and the Rise and Fall of Great Financial Centers' (ENFIN).

assistant: **Concept**

For all their differences, modern nation-states are both the energy transition leaders and financial leaders of their time. They are also home to our great financial centers (GFCs), and the question of the rise and fall of GFCs is a matter of longstanding debate. Existing explanations struggle to explain the timing and forecasting of the rise and fall of GFCs in a systematic manner. No researcher has connected the dots between energy transitions, financial transitions, the role of financial systems, and the rise and fall of great financial centers. My nontraditional hypothesis is that energy transitions drive financial transitions and GFCs.   The core aims of ENFIN are:   Create a new field of research integrating elements from comparative institutionalist literature, socio-technological transition research, and research on financial centers.   a) Integrate the role of energy transitions in the literature on financial centers. I will use cross-national and cross-temporal comparisons to establish the sequences and relationship between energy transitions and financial transitions.   b) Lift the analytical power of socio-technological transition research with regard to the reciprocal logic of low-carbon energy and green finance transitions. I will examine causal mechanisms through inductive process tracing on evidence about the pressures arising from energy transitions on existing financial structures and socio-economic actors’ responses.   c) Investigate the role of institutions in the relationship between green-energy transition and future financial leadership. I will conduct σ-convergence analysis to develop a global database to compare green financial standards by countries and a multigroup latent growth curve (LGC) model to compare and predict growth trajectories of m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Train Crashworthiness for Europe Railway Vehicle Design and Occupant Protection'.

assistant: **Objectives**

Railways are a particularly safe mode of passenger transport. This high level of safety is achieved through active systems such as signalling. Nevertheless train accidents (particularly end collisions between trains and collisions between trains and road vehicles at level crossings) continue to occur and result in fatalities and serious injuries to passengers and crew; on average over 100 passenger and crew fatalities a year occur in train accidents within the EU. The objective of this project is to devise standards for vehicle construction, based on measures to improve vehicle crashworthiness and occupant survivability, which will, in due course, lead to a substantial reduction in the overall rate of fatalities to rail passengers and crew in the EU. A more specific target will be developed after a more detailed review of accidents within the project. This project will outline the philosophy for the design of railway vehicles so as to achieve the objective of reducing casualties as is described above and to bring forward appropriate standards and codes of practice which will be applied to trains in the future. Although the application of active safety through the signalling system is fundamental to railways, passive safety (the crashworthiness of vehicles) will continue to need attention and improvement.The main principles can be set down as: provide collapse zones capable of absorbing the collision energy in accidents up to (15rn/s 54 km/hr). The collapse zones would be in areas not occupied by passengers; avoid vehicle overriding, reducing the extent of vehicle collapse and hence casualties; limit accelerations experienced by passengers; provide additional protection to staff located at ends of trains e.g. Cab occupants. This leads to a structural design philosophy ba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Generative Pre-Training on MEDical event streams in Intensive Care' under Horizon Europe.

assistant: **Concept**

Background: Artificial intelligence (AI) holds great promise for improving patient care, but challenges related to data irregularity and complexity have hindered its translation into clinical practice. Modelling rich longitudinal electronic health records (EHRs) such as those found in intensive care units (ICUs) remains especially difficult, as they represent a complex interplay between the patient’s health and clinical decisions made in response.Objectives: We aim to develop a robust AI framework for flexible prediction of any outcome in the ICU and beyond. We will pioneer a class of generative pre-trained models optimised for complex EHR data (Objective 1). Our approach will be rigorously benchmarked across outcomes and hospitals (Objective 2) on a secure, federated infrastructure that ensures data privacy (Objective 3). Methods: Our approach treats EHR data as a stream of clinical events in continuous time and uses generative pre-training to learn both the likely time and the content of the next event. From generated sequences of future events, we will derive explainable predictions for any clinical outcome, including those not encountered before (zero-shot learning). Our approach will be powered by the largest set of harmonised multicentre ICU data to date, covering up to 1 million patients with 33 billion clinical events. We will refine existing methods in federated learning to allow for secure decentralised training of our models at scale.Innovation & Impact: Our work will introduce a novel paradigm for AI-based clinical risk prediction, setting the stage for a new era of flexible, general-purpose AI in medicine. Our unprecedented multicentre benchmarks will provide an urgently needed baseline for meaningful innovations in the field, while our federated approach w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cell type-specific molecular analysis of epigenetic changes and transposable element derepression in Alzheimer's disease progression' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Alzheimer’s disease (AD) is a major contributor to disease burden and healthcare costs worldwide. AD is usually diagnosed once symptoms like memory impairment become evident. However, at this point typical AD pathology such as Aβ plaques and cell death is already widespread, suggesting that molecular changes have occurred decades before symptom onset. With an increasingly aging population and no available treatments, it has become imperative to identify the molecular mechanisms underlying onset and progression of AD. Chronic environmental stress and age-associated changes in stress response have been associated as drivers of AD pathology. The epigenome plays a critical role in translating stress signals into a cellular response by influencing gene expression, which can either promote or inhibit cell survival. Several studies have shown that alterations in chromatin structure, including heterochromatin loss, and associated changes in gene expression contribute to neurodegeneration. In addition, neuronal death was also linked to transposable element (TE) dysregulation due to epigenetic changes, which can lead to changes in gene expression and insertional mutations due to transposition. However, our understanding of epigenetic changes at onset and during progression of AD pathology is very limited, as current studies have two major limitations: 1) lack of cell type resolution due to use of bulk tissue samples and 2) coverage of only few or only one disease stage.Here, single-cell RNA-seq and ATAC-seq as well as CUT&RUN on isolated hippocampal neuron subtypes will be used to identify cell type-specific alterations of gene expression and gene regulatory mechanisms during onset and progression of AD pathology in the APP/PS1 mouse model. APP/PS1 mice are a well-established AD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'A legal advisory system concerning electronic data interchange within the European Union'.

assistant: **Innovation**

The project aims at the creation of a legal advice system on legal aspects of EDI. The JURICAS advice system shell will be used therefore. The project will include issues such as: an horizontal description and analysis of all EDI agreements, types and the ways to draft them, a vertical analysis of the issues which are usually included in EDI agreements, a proposal of alternatives to interchange agreements, it will allow users (SMEs), to draft their own interchange agreements, it will propose ways for alternative dispute resolution (ADR) in an EDI environment, it will provide a survey of national and international efforts for the regulation of EDI. The project aims to offer a high level of information and direct accessibility to the users. For increased user friendliness it will feature : a hypertext facility, document generation, a user interface (for EDI users, network provider), a subject interface.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of urban greenspaces to improve the quality of life in cities and urban regions (URGE)' (URGE).

assistant: **Innovation**

The project considers urban green spaces as important contribution to sustainable development of urban areas. Their ability to improve the quality of urban life is recognised while the present state of urban green spaces are considered as sub-optimal. Therefore the project elaborates an interdisciplinary catalogue of methods and measures referring to urban green policy, based on the experience of European cities organised in a network. The catalogue contains criteria suitable to evaluate ecological, social, economic and planning issues and is verified by application on evaluating model green spaces. Those are provided as 'best practice' by collaborating cities. Comparing the evaluations enables a ranking of green spaces by their contribution to quality of life. Conclusions can be drawn to evaluate the effectiveness of applied national and regional politics. They will be used to optimise existing and alternative strategies in urban green politics in Europe.