RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Methylaluminoxane (MAO) activators in the molecular polyolefin factory'.

assistant: **Concept**

MAO-ROBOTS address the aspects of call NMP2009-1.2-2 molecular factory. We aim to perform basic research on nano-to-micro-sized systems used for industrial polyolefin (PO) production in order to “develop sustainable processes for nano-structuring for specific applications which should present high potential industrial and/or market relevance.” Molecular PO factories consist of methylaluminoxane based structures and a transition metal complex often but not always anchored on a heterogeneous, nano-structured silica support. On the basis of an in-depth understanding of the molecular and supra-molecular assembly and construction principles of MAO we aim to: Create MAO building blocks with a narrow molecular weight distribution and optimum nanostructure in terms of their activation efficiency, probably in the range of molecular weights ≈1000g/mol, “to achieve components and/or systems with predictable and controllable properties such as the composition and physico-chemical structure.” Identify the most productive nano-to-micro structural arrangement (molecular factory layout) of the components MAO, transition metal complex and silica support in order to create “structures with controlled properties over multiple scales, multi-component structures” Establish the basis for reproducible production of the above-identified and newly designed molecular PO factories. Develop methods for quality control of the polyolefin production process in the molecular PO factories on a laboratory scale. Validate the results for the newly developed molecular factories from the laboratory scale by a series of test runs in industrial polyolefin production facilities Stimulate the broader application of nano-structured MAO for an increased spectrum of molecular factories, thereby accessing a broade
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Theoretical prediction of spectral biomarkers for Alzheimer's disease enabled by highly efficient and adaptable mutli-level response methods' (FreezeAlz), addressing dissemination and exploitation.

assistant: **Impact**

Luminescent conjugated oligothiophenes are highly promising candidates for biomarkers for amyloid misfolds and thereby for early-stage detection of neurodegenerative diseases such as Alzheimer’s and Parkinson's disease. The elucidation of the microscopic mechanism and design principles behind these biomarkers requires theoretical assistance. Finding suitable theoretical models that allow sufficiently accurate spectra calculations for such large, dynamic, and complex biomolecular systems is a highly challenging task: In practice, it is currently neither possible to include all possible factors, nor to rigorously test their importance for the actual simulation. There is, hence, a great need for efficient and adaptive theoretical models capable of incorporating the essential factors in spectra calculation of biomolecular systems sufficiently accurately.In order to devise an efficient and adaptable methodology for assisting the interpretation of existing spectra and predictingthe performance of new candidates for biomarkers, we will combine the advantages of several state-of-the-art computational methods. More precisely, we will combine the so-called frozen density embedding scheme with linear scaling density functional theory techniques and incorporate additional polarization effects in a manner inspired by the polarizable embedding method. We will moreover devise efficient and pragmatically adaptable schemes to accurately capture vibrational coupling in these spectra. All these method developments will be done in close collaboration with groups conducting the actual experiments. In this way, a strong interdisciplinary research project will be established. Still, the formulation and implementation of the new methods will be as general as possible in order to devise flexibl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hidden Hunger, Forgotten Food' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Food Security is a grand challenge of our time, but three factors inhibit our ability to meet global targets. First, interdisciplinary approaches incorporating ecological, social, and health sciences are fundamental, but lacking. Second, a disproportionate focus on food quantity overlooks ‘hidden hunger’, or micronutrient deficiencies, which are implicated in over a million deaths annually. Third, small-scale fisheries (SSF) reach 100s of millions of people in the developing world, hold potential for achieving food security, but remain ‘forgotten food’ in global discourse. Consequently, an interdisciplinary approach that tackles hidden hunger within SSF is a critical frontier for food security research.Fish are particularly high in many micronutrients, but a systematic understanding of which species have the greatest concentrations of key nutrients is needed. Inadequate access to nutritious food is one of the most significant problems of the modern age, which can be illuminated through analyses of power. The failure to realise the tremendous potential for improving food security through fisheries stems from a lack of understanding of how social drivers exacerbate or ameliorate nutritional inequalities. Consequently, an in-depth analysis that quantifies how key social drivers impact nutritional inequality, is essential.FAIRFISH will address these gaps to uncover the ecological and socio-cultural determinants of the contributions SSF make to human health:1. Establish the ecological and environmental determinants of nutrient availability among fish species using a traits based approach. 2. Advance social practice theory, by integrating an analysis of power, to determine what power relations enable or constrain access to nutritious food. 3. Progress interdisciplinary scienc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Histone modifying enzymes as direct regulators of metabolic reprogramming: Towards a New Paradigm' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Accumulating evidence in recent years has highlighted strong regulatory interactions between epigenetic mechanisms and metabolic transformations, mainly through transcriptional control of key metabolic genes. However, what has been overlooked is the direct effect of histone modifying enzymes on cellular metabolism as they are large consumers of sentinel metabolites. Therefore, I hypothesize that histone modifying enzymes and their mediated post-translation modifications (PTMs) on histones directly drive metabolic rewiring which subsequently impacts various cellular processes including gene expression. Specifically, this fellowship will focus on histone acetyltransferases (HATs) that use acetyl coenzyme A (Acetyl-CoA) as their sole substrate. Using interdisciplinary, state-of-the-art approaches that integrate subcellular metabolomics and high-throughput epigenomic techniques I will interrogate how the activity of HATs controls the abundance of acetyl-CoA and, in turn, defines the metabolic status of a cell leading to a subsequent reciprocal effect on the epigenetic landscape and genome regulation. Firm preliminary data, that I have recently generated, support the proposed project hypothesis and demonstrate that the experimental design is credible. During this project, my in-depth knowledge of metabolism and mass spectrometry skills will be combined with the expertise of epigenetics and histone biology that I will acquire at the host lab to reveal a new pathway through which histone PTMs function. This work will unveil a new fundamental link between epigenetics and metabolism and will be the commencing point for important future work in health and disease. Importantly, this fellowship will propel my academic career and help me become a scientific leader at the interface o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Evolution of Direct Reciprocity in Complex Environments'.

assistant: **Concept**

Direct reciprocity is a fundamental mechanism for cooperation among non-kin. It is based on the idea that individuals are more cooperative when they interact in stable groups in which retaliation is possible. To model the evolution of reciprocity, researchers have used the framework of repeated games. Traditionally, these models rest on two assumptions. First, players are symmetric: they coincide in their strategic options, in their incentives to cooperate, and how they discount future payoffs. Second, the players' environment is fixed: players face the same game, with the same payoffs, in every round. Both assumptions are crucial, as they promote conditionally cooperative strategies like Tit-for-Tat.  Yet in most natural applications, individuals are heterogeneous, and the games they play change over time.   To address these two critical model limitations, we need to expand the theory of reciprocity. We focus on the following objectives: 1) Develop a theory of reciprocity in heterogeneous groups. Based on mathematical models and simulations, we study how different dimensions of heterogeneity affect the evolution of reciprocity. 2) Develop a theory of reciprocity in changing environments. Here, we explore the evolution of cooperation when the players' environment (and hence their feasible payoffs and strategies) can change from one round to the next. We ask which environmental feedback is most favorable to cooperation. 3) Explore the dynamics of asymmetric games with changing environments. Here, we analyze the intricacies that arise when both previous sources of complexity are present. 4) Verify the theory using behavioral experiments with human subjects. The success of the project will establish a novel framework and new tools to study the evolution of strategic behavi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'The potential contribution of skeletal muscle to TDP-43 associated ALS.'.

assistant: **Innovation**

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by motor neuron degeneration that leads to progressive muscle atrophy. Currently only a few FDA-approved drugs are available for ALS, which merely extend patients’ life by a few months. Thus, there is an urgent need for new and more effective disease-modifying treatments. Although ALS is characterized by selective motor neuron degeneration, extensive evidence indicates that other cell types contribute to both onset and progression of ALS. An unresolved question in the ALS field is whether skeletal muscle fibers are merely bystanders or rather active contributors to motor neuron degeneration in ALS, and if so, through which biological pathways. Previous and ongoing work by the host laboratory has demonstrated the contribution of skeletal muscle in FUS-ALS, (1-2% of ALS cases). As TDP-43 cytoplasmic inclusions are a universal feature in nearly all ALS patients, assessing whether mutant TDP-43 toxicity in muscle contributes to ALS may be relevant to the broad community of ALS patients. I hypothesize that TDP-43 toxicity in skeletal muscle contributes to motor neuron degeneration and ALS-related phenotypes through specific molecular programs. I will use genetic and viral approaches to modulate mutant TDP-43 levels specifically in skeletal muscle in a TDP-43-ALS mouse model, and assess the effects on ALS-related phenotypes. Moreover, I will use single-nucleus RNA sequencing, a cutting-edge technique that became recently available, to determine – for the first time – the biological function of TDP-43 in skeletal muscle in the context of ALS, and to potentially identify novel therapeutic targets. Indeed, if mutant TDP-43 expression in skeletal muscle would influence the age of disease onset
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enhancing the (cost-)effectiveness of diabetes self-management education:  A comparative assessment of different educational approaches and conditions for successful implementation' under Seventh Framework.

assistant: **Concept**

The project aims to contribute to building the evidence base to increase the effectiveness of diabetes self-management education in the EU Member States, as part of a comprehensive diabetes strategy at EU level. To that effect, it will perform a systematic and comparative content analysis of the national diabetes strategies and frameworks across the 27 EU MS, establish a compendium of diabetes self-management education programs in the MS, and assess the costs of diabetes education at present on a per person basis at a national level. To enhance the cost-effectiveness of diabetes treatment and care, it will assess and compare the effectiveness and cost-effectiveness of different methods for diabetes self-management education (individual and group education, IT based education, and self-help), assess the implementation fidelity of current diabetes self-management education programs, consider the moderating role of health literacy in self-management education for diabetic patients and develop and test literacy-appropriate diabetes education materials. It will also assess the conditions for effectiveness of self-management education programs in the way the health services are organised. The results will be used to inform policy decisions on improving the treatment and care for diabetic patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European Network Against Crime and Terrorism' (ENACT) targeting Horizon Europe.

assistant: **Abstract**

The programming of Security R&I is a highly sensitive exercise which has grown in complexity during the past years. Moreover, the uptake of innovation stemming from EU-funded security R&I projects remains a challenge. The goal of ENACT is to set up a Knowledge Network for Security R&I in the Fighting Crime and Terrorism area capable of i) supporting the EU-funded FCT security R&I cycle and the overall community and market actors with actionable evidence, and ii) boosting the Innovation Uptake of the outcomes and results stemming from FCT Security funded R&I projects.ENACT brings together the most unique blend of knowledge, background, skills, resources and connections to: i) deliver a network-enabling service that facilitates the exchange of knowledge and value within the wider FCT community; ii) catalogue, aggregate and exploit the existing knowledge on the FCT area ensuring continuous availability of a structured knowledge base accessible to decision makers of the various R&I domains; iii) communicate project activities and disseminate & exploit project findings in a timely manner, ensuring continuous availability of updated actionable knowledge in each of the four domains addressed, namely capabilities, technology, market and SSH; iv) foster cooperation between FCT market actors in order to improve the market visibility and the uptake of innovation, and; v) ensure the sustainability of the “knowledge as a service” model and the enabled networking environment beyond the project duration.To operationalise these five pillars, ENACT will implement coordination and support measures to extract information from the FCT R&I Community making use of the project’s connections with specific Knowledge Hubs. It will also classify the information according to a recognisable taxonom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Analytical microfocus X-RAY-PEN' (1994-1998).

assistant: **Concept**

Two dimensional elemental surface microanalysis is traditionally performed with Scanning Electron Microprobe (SEM) or hole collimated X-Ray microfluorescence analysis ( XRF). The problem with the electron beam microprobe is that it requires a vacuum for making the analysis and the samples need to be conductive. The X-Ray induced XRF does not have this problem, but the hole collimator based systems have been too slow for most applications. The objective of this research project is to overcome these limitations by studying a new idea to realise the microanalysis by making use of the two recently developed technologies: High purity silicon detectors and X-Ray Capillary Optics (XCO). By placing the high purity silicon detectors to the close vicinity of output of the XCO tube, it is possible to fasten the measurement time of the XRF analysis with a factor up to 1000, compared to existing systems. The fields that can directly benefit from the new probe technology are, for example, the analysis of non-conductive samples, archaeological samples, hair and fiber samples, air filters, coatings in paper industry, composite materials or failure and uniformity analysis of semiconductors and hybrids.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Computational modelling of electromagnetic control of melt flows and heat/mass transfer during manufacturing of bulk photovoltaic materials' under Seventh Framework.

assistant: **Concept**

This is a continuation of our experimental and numerical study of instabilities of melt flows in Czochralski growth of optical oxide crystals, which we plan to extend for bulk growth of photovoltaic materials. Our general target is a full-scale computational modeling of a bulk crystal growth technological process. The research is based on state-of-the-art numerical codes, and experimental and numerical results, which were developed and obtained in our previous studies, in which we established cooperation between Tel-Aviv University (Israel), University of Nottingham (UK) and Institute of Crystal Growth (Berlin, Germany). Our recent results posed new unanswered questions and problems, which are being addressed now. This application is assumed to cover the expenses of a one year stay of Israeli PI in University of Nottingham. The computational codes we developed, as well as setups built for experimental modeling allow us to extend the study to other monocristalline materials. In the present project we wish to focus on manufacturing of photovoltaic materials needed for wider and more effective utilization of solar energy. In the framework of the project the model experimental studies will be continued in Tel-Aviv University, the computational codes will be developed in University of Nottingham by joined efforts of UK and Israeli PIs, crystal growth experiments and the heaviest computations will be carried out in Berlin. The numerical codes will be extended to include additional physical effects and to be able to run fully 3D simulations thus reflecting real growth conditions.