RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Screening method for Water data Information in support of the implementation of the Water Framework Directive' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The monitoring requirements for successfully implementing the WFD will directly depend upon available measurement techniques of demonstrated quality, which will be able to deliver reliable data at unaffordable cost. Besides the necessary classical" laboratory analyses, screening methodologies will play a key role in the WFD implementation, in particular for the detection of accidental pollution or the control of water bodies at risk. The WFD will represent a powerful management tool only if monitoring data are of reliable and comparable quality. The costs of wrong decisions based on erroneous data could be tremendous, which justifies that Community efforts are made to ensure that data are produced according to a proper quality assurance regime. In the light of the above, the objectives of SWIFT-WFD should focus on the production of quality control tools for validation purposes of screening methods, an inventory of existing screening test (chemical and biological) methods through laboratory-based (tank experiments) and/or field interlaboratory studies based on a selection of reference aquatic ecosystems at European scale, and with classical laboratory-based analyses to validate their results and demonstrate their equivalence for parameters regulated both WFD. In parallel, the project should consider the development of new "low-cost", innovative, screening techniques (both for chemical and biological parameters) and their validation using the same approach (interlaboratory testing and comparison with laboratory-based methods). In addition, exchange of knowledge, transfer of technologies and training related to water monitoring will represent a key issue for ensuring the comparability of data produced by screening methods"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A coherent view of Glasses: How coherent x-rays can elucidate the complex dynamics of glasses' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Glasses are mysterious materials. Fundamental blocks in many natural and technological processes, still, their properties keep puzzling a large community of scientists nowadays. Following different experimental routes, materials as diverse as colloidal suspensions, emulsions and viscous liquids can be driven in an out-of-equilibrium state, where they solidify under conditions that still remain unknown. This process, traditionally called glass transition, leads to many intriguing phenomena as the emergence of multiple relaxations processes, dynamical heterogeneities, crossovers between distinct amorphous states, and uncommon mechanisms of particle motions.  Within the large family of disordered systems, structural glasses play a key role being often considered as archetypes of out-of-equilibrium materials. Despite decades of studies, a microscopic theory of glasses is still missing due to the difficulty to probe their atomic motion with experiments and simulations. Few years ago, I used coherent x-rays to perform the first worldwide experiments probing the atomic motion of glasses. My works reported on a surprising glassy dynamic reminiscent of an anomalous stress-driven particle motion observed in some soft systems. Due to severe technical constraints, the studies performed so far were limited to the external, tiny portion of the huge ""iceberg” of dynamical features occurring at the atomic level, whose comprehension would enable substantial advances in the frontiers of knowledge.Thanks to the new possibilities offered by coherent x-rays, now is the right time to unveil the atomic dance of glasses in all its complexity with the CoherentGlasses project. Following four challenging experimental Research Objectives, we will provide a coherent picture of the microscopic dyna
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Super-enhancer modules controlling plasticity and response to therapy in pancreatic cancer', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Recently discovered subtypes in pancreatic ductal adenocarcinoma (PDAC) have potential to better guide the choice of therapy. However, this is challenged by the lack of robust data, patient heterogeneity, tumour cell plasticity, dynamic crosstalk with surrounding cells, and post-chemotherapy induced alterations. A few transcription factors may act as drivers of specific PDAC subtypes and changes in there expression through aberrant activation of super-enhancers may lead to ‘’subtype switching’’. However, the effect of the tumour-microenvironment on enhancer-driven gene expression programme to promote ‘’subtype switching’’ in pancreatic tumour cells remains largely unexplored. Hence, with this proposal I aim to provide in-depth characterization of this dynamic crosstalk combining reporter tracing through fluorescent labelling of subtype-specific transcriptional drivers of tumour cell states with powerful high throughput single-cell technologies, and super-enhancer single cell profiling which will translate to a clinical study of neoadjuvant chemotherapy with sequential tumour sample profiling. This work will ultimately provide a platform for the development of methods to precisely determine the ""phenotypic"" state of PDAC cells and aid in designing new agents to target these processes, with the ultimate goal of converting non-responder to responder tumours and improve patient outcome.""


**Keywords:** PDAC, plasticity, tumour microenvironment, super-enhancers, therapy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A simple blood test to monitor disease progression in patients undergoing cancer therapy'.

assistant: **Objectives**

The ultimate objective of the ONCOCHECK project is to bring to the healthcare market a unique solution for cancer monitoring which is a simple blood test that will allow oncologist the evaluation of disease progression in patients affected by the great majority of cancers, with no distinction between haematological of solid tumours. Our test will be based on the determination of telomere length in peripheral blood, which is a cancer biomarker that has been identified in the great majority of cancers.   The ONCOCHECK test will offer to the healthcare community a test that is simpler (blood test), less costly (200€/test) and more effective (regular monitoring will lead to improved efficiency) as an alternative to other cancer monitoring alternatives that are expensive (2.000-5.000€), complex (need for specialized and very expensive equipment) and less effective (impossible to be performed regularly) imaging techniques conventionally used in the clinic. Moreover, the great advantage of the ONCOCHECK tests over other newly developed competing blood tests based on validated biomarkers is that ONCOCHECK will serve for monitoring all types of cancer, while competing biomarker based solutions are useful only for a specific cancer/tumour. Therefore, Life Length´s test will offer a universal solution for cancer monitoring, with no competitors offering a similar approach.Considering that there are more than 35 million of people affected by cancer all over the world and that the ONCOCHECK will serve for monitoring all cancer types, the business opportunity seems unquestionable.  Through the ONCOCHECK project, we seek positioning our company as a leading player on the Advanced Next Generation Cancer Diagnostic Market, which is estimated globally at €5.3 billion in 2015 and expected
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Variational problems in geometric analysis' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content During the last few years I have been working in the general area of Geometric Analysis. I am interested in the study of area minimizing and minimal submanifolds, harmonic maps, and other related variational problems, where insight on existence and /or regularity properties of the solutions can be attained by bringing together tools from the theory of Partial Differential Equations, Geometric Measure Theory, and Diffential Geometry. Amongst other things, I propose to examine some questions concerning minimizing the area functional in certain classes of lagrangian submanifolds of a given symplectic manifold and the mean curvature flow. Training content (objective, benefit and expected impact) At this point of my mathematical career I have gained some experience in the fields of Geometric Measure Theory and Elliptic Partial Differential Equations, but I feel I need to improve my understanding of the more (differential) geometric aspects, and of other types of PDEs (in particular parabolic ones, in view of my interest in the mean curvature flow). I would hope to use a TMR grant to pursue these objectives. The Mathematische Institut at the University of Bonn is one of the leading centers in the field of Geometric Partial Differential Equations, thus the experience gained there would certainly contribute greatly to my further development as a researcher.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'AI technologies for enhancing capabilities, greater efficiency and effectiveness for customs'.

assistant: **Innovation**

EU customs authorities are a cornerstone in the international trade landscape, playing a critical role in preventing the entry of illegal goods, safeguarding revenue, & ensuring the seamless flow of goods. Balancing these responsibilities is particularly challenging in today’s environment, where the volume of global trade continues to expand rapidly. Mitigating the entrance of illegal goods is becoming increasingly difficult, especially with limited human resources.Aiming to address these challenges, the CustomAI consortium has united its expertise and competences to develop an AI-toolkit that will reduce the number of false positives (situations where the cargoes like shipping containers or parcels have been selected for inspection despite not containing contraband). The proposed AI-toolkit will revolutionise customs operations by involving non-intrusive and robust AI-enhanced technologies for predicting, detecting, and selecting high-risk cargoes for inspection. The VCCO concept is adopted for managing all processes in the customs control of artefacts (e.g. container, parcel). Key components of the AI toolkit include:* AI-based risk anticipation relying on AI-analysis of internal knowledge in compilation with external multilingual data, including manifest and declarations. Only relevant cargos will be sent for inspection.* AI-enhanced vapour-based detectors implied only on the containers selected in the previous step.* AI-based x-ray for threat detection in containers applied on output of step two (the human inspection takes place only after this step).* Multimodal LLM Continual Learning model, which will have as input, x-ray and camera images, and will be trained on threat dataset composed of threat samples (x-ray and visual images of threat parcels) updated by custo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'MicroScale system integrating Patient-specific cancer Organoids in a 3D Tumor microenvironment for Therapy rEsponse preDiction'.

assistant: **Concept**

Cancer remains a leading global cause of death, with incidence projected to increase significantly by 2050. Despite advances in detection and treatment, there is an urgent need for more effective and personalized therapies. Personalized medicine (PM) is emerging as the future of cancer care, using 3D patient-specific models to replicate the tumors complexity. Current in vitro models struggle to accurately mimic the tumor microenvironment (TME), including the extracellular matrix (ECM) and stromal interactions, which are critical to tumor progression and therapy response.SPOTTED aims to address these limitations by developing patient-derived (PD) in vitro models integrated into a microfluidic device, by exploiting patient-derived organoids (PDOs) from bioptic tissues from the Biobanca di Ricerca of the University Hospital of Padua. The first vertical case study is on pancreatic cancer (PC), projected to become the second deadliest type of solid tumor by 2040. Our SPOTTED platform will use PDOs and PD-ECM hydrogels to reconstruct a realistic 3D model of PC, incorporating stromal and immune cells. By replicating the TME, SPOTTED enables precise drug screening and therapeutic testing in a highly controlled and automated environment. Its design allows for real-time monitoring and analysis, while the platform’s versatility supports scalable, reproducible experiments tailored to individual patients.SPOTTED, with its customizable, patient-specific approach, aims to bridge the gap between laboratory research and clinical application, paving the way for more effective, tailored therapies for PC and other solid tumors, with the potential to revolutionize personalized cancer treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Non-rigid geometry variation for fabricated aero structure', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In traditional 3D variation simulation (stack-up’s) it is common to consider that the parts are rigid. However, often in production forces are applied manually or by different fixturing solutions to assure that requirements on offset are fulfilled before welding parts together in an assembly. This causes the parts to bend and rigid analysis is therefore not valid. Depending on assembly sequences and geometry variation of incoming material, different fixturing forces need to be applied from component to component to assure the right fit in the seam before welding. It may even be necessary to use active fixturing where the forces are varying during the welding process. The welding process itself also contributes with variation that needs to be considered in order to fulfil geometrical requirements.This project proposes a novel way to combine variation and welding simulation to support the design of future welding fixtures for aircraft engine components. Non-rigid Geometrical Variation Simulation will be further developed to optimize locator and support positions in order to minimize geometrical variation in the weld gap and also take fixturing forces into consideration. Computational Welding Mechanics simulations with integrated control functions will be further developed to prescribe fixturing forces for maintaining specific tolerances ahead of the weld for a stable weld process.The simulation areas will be combined and integrated to support the design of a physical welding fixture suitable for fabrication of aircraft engine components. The results will be demonstrated virtually and physically.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Time-resolved near infrared spectroscopy for non-invasive determination of blood oxygenation in brain tissue', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The aim of the probed is to develop a new method for non-invasive assessment of cerebral oxygenation by the use of near-infrared pulsed laser light. The proposed technique is based on the multi-distance and multi-wavelength time-of-flight measurement and will allow for the discrimination between intra- and extra cerebral signals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cell line engineering for imporved fertility treatment' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

kyron.bio is a female led biotech company on a mission is to unclog bottlenecks in therapeutic protein production, allowing better drugs to reach patients. We are using synthetic biology to engineer mammalian cell lines for improved bioproduction, harnessing highly efficient enzymes from diverse life forms. Our preliminary data demonstrates a 3X yield gain for the amount of therapeutic produced in our system, with further gains in yield, activity and stability predicted post optimisation


**Keywords:** Cell line engineering, Therapeutic production
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Energy-efficient digital outdoor billboards for sustainable advertising' (DynamicColor).

assistant: **Innovation**

Digital billboards are between 6 to 10 times more profitable than traditional printed billboards. The higher profitability is attributed to a higher turnover rate of displayed ads – thus, higher income – and to the reduced costs associated with changing the ads. Whereas traditional billboards require large format printers, a special high-altitude team, a 4x4 truck with crane and produce waste every time the ad is changed, digital billboard ads are changed remotely and can quickly publish new campaigns. State-of-the-art digital billboards are made of light emitting diodes – LEDs – that are lit 24h a day, every day. A 60 m^2 LED billboard uses up to 300 MWh/year depending on the display resolution, which is around €30,000/year – the equivalent to 17 average EU households.  We have developed and energy efficient digital billboard that has low OPEX and reduces environmental impact of current outdoor billboard solutions – less than 5% of the energy consumption compared to state-of-the-art LED billboards and zero waste compared to printed billboards that have to be changed every 10 days. We target billboard owners and advertising agencies who which to increase revenues by adopting digital billboards but are discouraged by the underachieving performance of LED billboards and their high OPEX costs. The out of home advertising market was forecasted to grow at 4% CAGR to reach €28 bn by 2021. Billboards represent 44% of market share - €10.8 bn – of which 98% are still non-digital billboards, which presents a big market opportunity for a high-performance technology. We are aiming to start scale up of our technology by the end of 2019, targeting €33M in revenues by 2023 with 88+ FTEs. In this Phase 1 project we will investigate our target market segments & develop a go-to-market st