RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Household Ecology. Consumption and Wellbeing in Early Modern Iceland' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

HECoW's aims are to quantify and qualify an observed increase in domestic consumption in early modern Iceland (1750-1900) in order to assess the effects new household material culture had on gender relations and the wellbeing of families. This will be achieved through an truly interdisciplinary, historical and archaeological, methodology applied to  two different data sources: historical probate inventories and artefact assemblages from archaeological excavations. These sources will provide information on what new materials were consumed by families during this period, how their introduction and spread varied across the social spectrum, from poorer labourers to land owning farmers, and how they were distributed through time. The project will be supervised by Prof. Lucas, who is a leading thinker in archaeological theory and practice. His supervision will provide the applicant with new abilities in archaeological analysis and increase her confidence in interpretation and communication of archaeological data. Specifically, his expertise in materially focused approaches and relational archaeology will guide the candidate in the application of the project's central theoretical concept of ""household ecology"" through which the affects of new material culture on gender relations and the wellbeing of households will be assessed.  The project's co-supervisor is Prof. Jónsson, who will train the applicant in historical approaches and the quantitative and qualitative analysis of probate inventories. Prof. Jónsson is an expert in Icelandic medieval and late medieval history and has studied Icelandic probate inventories and their use in historical research. His guidance will supply the applicant with new transferable skills in historical research, which will increase her employabi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'GENETIC FACTORS FOR OSTEOPOROSIS' under Seventh Framework.

assistant: **Concept**

Osteoporosis is a common, age-related disease with a strong genetic component. With increasing age of the population, Europe and industrialised countries across the globe are facing a substantial increase in osteoporotic fractures, which account for considerable disease-burden and costs. Early identification and treatment of subjects at risk can help preventing this, and genetic susceptibility alleles are the most promising risk factors in this respect. Large-scale prospective meta-analysis of individual gene polymorphisms in the EU-funded GENOMOS consortium was shown successful in identifying the expected subtle effects of  gene polymorphisms which predispose to osteoporosis. The recent development of powerful genome-wide genotyping technology now allows to identify -hypothesis free- strong and common genetic risk factors for complex diseases by Genome Wide Association (GWA) analysis. The AIM of the proposal is to identify osteoporosis susceptibility alleles by meta-analysis of GWA data obtained from a large collection of osteoporosis genetics cohorts in Europe and outside (n=46.000). Prospective meta-analysis of GENOMOS, a large consortium of  genetic studies on osteoporosis (n=80.000), is used to assess generalizability of genetic effects and develop sufficient power to quantify even small, but clinically important risks. The improvement in clinical risk-assessment for osteoporosis by adding the diagnostic panel of osteoporosis risk-alleles identified in this project, will be quantified in prospective studies including genetic and classical risk factors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multilingual locals, significant geographies: a new approach to world literature' (Mulosige) under Horizon 2020.

assistant: **Objectives**

“World literature is literature that circulates globally. It is mostly in English. Its main genre is the novel.” These are caricatures of how World literature as a set of discourses is shaping the field of literary studies, but in fact Non-Western literatures are positioned with reference to a single global timeline and a single map, and translations supposedly ensure that worthy texts enter the global canon. What does not circulate globally is provincial, not good enough, not “world literature”. This picture bears little resemblance to the multilingual world of literature, which consists not of a single map but of many “significant geographies” specific to language, group, and genre. By exploring the often fractured “multilingual locals” and “significant geographies” of literature in north India, Morocco, and Ethiopia—each with different experiences of literary multilingualism, colonial diglossia, and continuing oral traditions—we seek to establish a multilingual and located approach to world literature in place of meta-categories like “global” and “world”. Mindful of older histories and networks of literary multilingualism and critical of the monolingual straitjacket of modern literary histories that partition Anglophone and Francophone literature from Arabic, Amharic, and Hindi/Urdu, we focus on three periods: imperial consolidation, decolonization, and the current globalizing moment. We will study local transculturations, local debates on world literature, old and new forms of multilingualism, actors and technologies of print and orality, to highlight dynamics of appropriation rather than imitation, co-constitution rather than diffusion, and the multiplicity of choices and trajectories that together form local and transnational literary fields (“world literature”).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dedicated to stimulate demand for sustainable energy skills in the construction sector' (BUSLeague).

assistant: **Concept**

The overall  aim of BUSLeague is to address and overcome the challenges of the stimulation of demand for energy skilled workforce (demand side), along with hands-on capacity building to increase the number of skilled workforce across the building design, operation and maintenance value chain (supply side). BUSLeague will achieve this objective by developing and implementing a cross European recognition of energy skills, together with upscaling successful training methods and techniques which have already been developed in previous EU and National initiatives such as BUILD UP Skills, Construction Skills. BUSLeague focusses on a blend of four elements: mutual recognition of energy skills, awareness raising, capacity building and legislative changes. Implementation will be done at country specific and regional levels; based on a blend of measures to stimulate demand complimented with hands-on and practical upskilling of involved local and regional workforce. In this way engagement of SMEs will be ensured. BUSLeague is formed by a coalition of former BUILD UP Skills and Construction Skills projects. The partners believe that by working together the national implementation plans and developed means will improve and become more attractive and effective. BUSLeague is strengthened by experienced anthropology researchers and educational technology researchers in order to prove impact and to optimize the blends for stimulating demand and optimizing learning transfer of applied learning means and materials.


**Keywords:** sustainable energy, stimulation of demand, energy skills, mutual recognition, capacity building, legislative changes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Delivering anti-cancer drugs beyond the blood-brain barrier'.

assistant: **Concept**

Founded in 2010, CarThera is a clinical stage company that develops first-in-class medical devices using therapeutic ultrasounds to treat severe brain disorders (Glioblastoma, Brain Metastasis, Alzheimer’s Disease). The company is developing the SonoCloud Device, an implant emitting Low Intensity Pulsed Ultrasound (LIPU) to temporarily open the blood-brain barrier (BBB) on demand, thus enabling the targeted delivery of a higher concentration of therapeutics agents into the brain, up to therapeutic levels (5 to 7 times more than what is possible today). Its LIPU technology can physically increase the permeability of the blood vessels by a mechanism of action that is safe and reversible, allowing molecules to be delivered towards infiltrating brain tumor cells that are normally protected by the BBB.   The SonoCloud is offering for the first time in decades a means for clinicians to delay the recurrence and to prevent disease worsening in severe brain disorders like glioblastoma. The efficacy of chemotherapies will be increased. Encouraging results from a first-in-man were recently published in prestigious medical journals. It could also give a second chance to some of the hundreds of  drugs against brain tumors that have been abandoned and allow existing, approved oncology drugs to be repurposed for brain tumors, greatly accelerating clinical translation and potential patient benefit.  The DOMEUS project is at a pivotal moment, where CarThera is gathering data from an international (American/French), multi-center,  pilot clinical study with an enlarged version of the device (SonoCloud-9). The DOMEUS project will  allow CarThera to carry out a pivotal phase 2b/3 clinical trial, to industrialize the implant and to prepare for international market introduction in 2023. CarTh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Structure and Cellular Dynamics of the Sarcomere'.

assistant: **Concept**

Muscles are specialized tissues that power voluntary, fast and coordinated movements, a hallmark of animal life. The force-generating and load-bearing devices of muscles are called sarcomeres, highly structured ensembles of many proteins. While many sub-components are structurally and functionally characterised, muscle is more than the sum of these parts: its function is highly cooperative and its structure dynamic over time and space. The high-resolution structure of sarcomeres is unknown, yet a precise molecular understanding of how the entire sarcomere machine forms and functions is required to understand its role in health, disease and ageing. This consortium will deploy an unparalleled complementary knowledge and technology base to address these fundamental and translational questions. We will solve the structure of the sarcomere at near-atomic resolution, uMuscles are specialized tissues that power voluntary, fast and coordinated movements, a hallmark of animal life. The force-generating and load-bearing devices of muscles are called sarcomeres, highly structured ensembles of many proteins. While many sub-components are structurally and functionally characterised, muscle is more than the sum of these parts: its function is highly cooperative and its structure dynamic over time and space. The high-resolution structure of sarcomeres is unknown, yet a precise molecular understanding of how the entire sarcomere machine forms and functions is required to understand its role in health, disease and ageing. This consortium will deploy an unparalleled complementary knowledge and technology base to address these fundamental and translational questions. We will solve the structure of the sarcomere at near-atomic resolution, unravel the fundamentals of its force-driven assemb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mapping the Deprived Visual System: Cracking function for prediction' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

One of the most striking demonstrations of experience-dependent plasticity comes from studies of blind individuals showing that the occipital cortex (traditionally considered as purely visual) massively changes its functional tuning to support the processing of non-visual inputs. These mechanisms of crossmodal plasticity, classically considered compensatory, inevitably raise crucial challenges for sight-restoration. The neglected relation between crossmodal plasticity and sight-recovery will represent the testing ground of MADVIS in order to gain important novel insights on how specific brain regions become, stay and change their functional tuning toward the processing of specific stimuli. The main goal of MADVIS is therefore to make a breakthrough on two fronts: (1) understanding how visual deprivation at different sensitive periods in development affects the functional organization and connectivity of the occipital cortex; and (2) use the fundamental knowledge derived from (1) to test and predict the outcome of sight restoration. Using a pioneering interdisciplinary approach that crosses the boundaries between cognitive neurosciences and ophthalmology, MADVIS will have a large impact on our understanding of how experience at different sensitive periods shapes the response properties of specific brain regions. Finally, in its attempt to fill the existing gap between crossmodal reorganization and sight restoration, MADVIS will eventually pave the way for a new generation of predictive surveys prior to sensory restoration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'IMPlementation of Affordable gene Correction Therapies' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Rare genetic diseases affect over 30 million people in Europe. Although individually rare and very diverse, they are all caused by genetic mutations. Recent progress in genetic technologies now holds the promise to correct the root cause of these diseases. However, it remains difficult to develop these innovative technologies into affordable therapies for these diseases that only affect few patients, limiting commercial interest.IMPACT aims to overcome the translational gap between scientific gene editing and in human gene correction therapies that will be affordable and readily available for patients with rare genetic diseases.To overcome this gap, we will use a multifaceted approach to set up the infrastructure for a gene correction therapy for Methylmalonic Acidemia (MMA) by elucidating and addressing the essential (1) regulatory, (2) manufacturing, and (3) financial requirements. This approach involves preclinical testing of the therapy in a perfused ex vivo human liver, clarifying the intellectual property strategy, and involving experts, stakeholders, and end users to define the regulatory, manufacturing, and financial strategies required for academic development and clinical implementation. As such, IMPACT aims to valorise the innovative gene correction strategy developed with the ERC Starting Grant to deliver prime editing tools as mRNA encapsulated in lipid nanoparticles to correct the disease-causing mutation in the liver of patients with MMA.With IMPACT, we do not only aim to develop gene correction therapies in our academic hospital for MMA. Through our efforts in generating the infrastructure for a therapeutic platform approach with only slight adaptations to target different mutations, we ultimately aim to develop therapies for the many patients with diffe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'High resolution spectroscopic and theoretical studies of lithium hydride' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content  Our objectives are to study the electronic and rovibronic structure of high energy lying states of the isotopic lithium hydrides using high resolution multiple resonance spectroscopic techniques. Multiple minima are predicted to exist in the potential energy curves of these states but they have yet to be observed. A two laser excitation scheme will be used to reach the Rydberg states of nLimH. By scarming the second laser and detecting the laser induced fluorescence and/or the ion signal, we will explore those states for the first time. We will also study spim-orbit perturbations that have been predicted to be small and require high spectral resolution, attainable with this scheme. Calculations will be performed for LiH im order to improve existing quantum mechanical methods. Training content (objective, benefit and expected impact)  This work will extend and consolidate my previous experience with single mode dye and Ti:sapphire laser systems, pulses . lasers and ion detection techniques, particularly by working with the frequency doubled high resolution pulsed amplified lasers developed at Lab Aime Cotton. Working with one of the foremost French groups in theoretical calculations for small molecular systems, I will acquire expertise in theoretical molecular physics, which will complete my profile as a molecular spectroscopist.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Improving tropical forest conservation in Africa' in the context of a Horizon Europe call.

assistant: **Objectives**

The importance of non-timber forest products (NTFPs) for better balancing tropical forest conservation and poverty alleviation goals is increasingly recognised. Yet, in Africa, poor understanding of the impact of harvesting on species’ populations and forest carbon stocks, together with little information on the traditional institutions which have informally regulated NTFPs extraction in the past -and could continue to do so in the future-, hamper the use of NTFPs in both forest conservation and development initiatives. AFRI-FOR will gather the knowledge needed to determine (1) the key enablers of sustainable harvesting for groups of plant or wild meat species, (2) which types of NTFP harvesting can have synergies with carbon storage, and (3) how traditional institutions can be integrated into formal conservation. To achieve these objectives, AFRI-FOR provide new methods, including (i) a new interdisciplinary approach for investigating NTFPs harvesting impacts, combining traditional ecological knowledge (TEK, from local communities), surveys of plants and wildlife, market surveys and modelling techniques; and (ii) a novel standardised protocol for gathering information about traditional institutions and compliance towards them. AFRI-FOR will gather data and knowledge from 20 socio-ecological forest contexts in five countries (Sierra Leone, Cameroon, DR Congo, Uganda and Kenya), which will allow insights to transcend single sites and provide a much-needed general understanding. This high-risk and high-gain project will provide a step-change in our ability to inform forest conservation in Africa, by identifying synergies between biodiversity conservation, carbon storage and poverty alleviation goals.


**Keywords:** Tropical forests, conservation, biodiversity, carbon sto