RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'DEveloper COmpanion for Documented and annotatEd code Reference' (DECODER) targeting Horizon 2020.

assistant: **Abstract**

Software is everywhere and the productivity of Software Engineers has increased radically with the advent of new specification, design and programming paradigms and languages. The main objective of the project DECODER is to introduce radical solutions to increase productivity and by means of new languages that improve the situation by abstractions of the formalisms used today for requirements analysis and specification.  We will develop a methodology and tools to improve the productivity of the software development process for medium-criticality applications in the domains of IoT, Cloud Computing, and Operating Systems by combining Natural Language Processing techniques, Modelling techniques and Formal Methods. The combination is a novel approach that permits a smooth transition from informal requirements engineering to deployment and maintenance phases. A radical improvement is expected from the management and transformation of informal data into material (herein called ‘knowledge’) that can be assimilated by any party involved in a development process. Thus, the DECODER project will 1) introduce new languages to represent knowledge in a more abstract manner, 2) develop transformations leading from informal material into specifications and code and vice-versa, 3) define and prototype a Persistent Knowledge Monitor for managing all relevant knowledge, and 4) develop a prototype IDE. The project will automate the transformation steps using existing techniques from the Big Data (knowledge extraction), Model-Driven Engineering (knowledge representation and refinement), and Formal Methods (specifications and proofs). The project will produce a novel Framework combining these techniques and demonstrate its efficiency on several uses cases belonging to the beforehand mentione
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Soft Biomade Materials: Modular Protein Polymers and their nano-assemblies' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

From a polymer chemistry perspective, the way in which nature produces its plethora of different proteins is a miracle of precision: the synthesis of each single molecule is directed by the sequence information chemically coded in DNA. The present state of recombinant DNA technology should in principle allow us to make genes that code for entirely new, very sophisticated amino acid polymers, which are chosen and designed by man to serve as new polymer materials. It has been shown that it is indeed possible to make use of the protein biosynthetic machinery and produce such de novo protein polymers, but it is not clear what their potentials are in terms of new materials with desired functionalities.I propose to develop a new class of protein polymers, chosen such that they form nanostructured materials by triggered folding and multimolecular assembly. The plan is based on three innovative ideas: (i) each new protein polymer will be constructed from a limited set of selected amino acid sequences, called modules (hence the term modular protein polymers) (ii) new, high-yield fermentation strategies will be developed so that polymers will become available in significant quantities for evaluation and application; (iii)  the design of modular protein polymers is carried out as a cyclic process in which sequence selection, construction of artificial genes, optimisation of fermentation for high yield, studying polymer folding and assembly, and modelling of the nanostructure by molecular simulation are all logically connected, allowing efficient selection of target sequences.This project is a cross-road. It brings together biotechnology and polymer science, creating a unique set of biomaterials for medical and pharmaceutical use, that can be easily extended into a manifold of biof
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ESConet Trainers' (ESCONET).

assistant: **Concept**

This proposal by ESConet Trainers is to train high-level EC-funded scientists in science communication skills, so that they can interact effectively and confidently with the mass media, so that they can make use of the internet and its capabilities, and so that they can engage European citizens in dialogue about science in society issues. Our team combines the talents of media and policy professionals, with a solid basis in science communication training. It builds on highly successful science communication training workshops and modules developed under FP6, and raises the European dimension in such training.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Reframing European Gastronomy Legacy through Innovation Sustainability and Heritage' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Through an innovative and systematic approach to the understanding and use of traditional EU recipes via digital and AI-powered technology, RELISH embarks in the production of a visual and verbal food storytelling web platform that aims to mediate social cohesion, reinforce EU cultural heritage transmission at home and abroad through education and public engagement, while addressing sustainable practices in the EU hospitality sector.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deep learning analysis of imaging and metabolomic data to accelerate antibiotic discovery against antimicrobial resistance' to be submitted under Horizon Europe.

assistant: **Abstract**

Antimicrobial resistance (AMR) is one of the most pressing global health problems of our times. To counteract AMR, we urgently need new antibiotics, particularly with novel modes of action (MoA). However, while typical antibiotic screening pipelines can identify compounds that impair bacterial growth, they are unable to predict drug targets and MoA so must be followed up by time-consuming target identification steps. By synergizing our expertise in microbiology, genetics, advanced microscopy, metabolomics, medicinal chemistry, computational biology and artificial intelligence (AI), we propose to create a new pipeline at the forefront of the antibiotic discovery field that will be capable of informing simultaneously on the bioactivity and MoA of new antibiotic candidates. Working with seven pathogens, our improved acquisition strategies for both imaging-based high-content screening and metabolomics will generate a massive dataset of rich multidimensional phenotypes of libraries of genetic mutants and of bacteria exposed to a range of perturbants, at unprecedented scale. Deep learning analyses will then enable us to explore these massive datasets to correlate chemical-induced phenotypes to those from mutants, linking drugs to genes to elucidate the target/MoA of new drugs. This innovative pipeline will enable us to explore unique chemical spaces, including complex natural product extracts (without the need for isolation of individual components) and novel synthetic compounds. Promising candidates with novel MoA will be tested against drug-resistant clinical isolates and against a future pandemic 'pathogen X', demonstrating our pipeline as an AI-powered solution for achieving higher productivity in antibiotic discovery. AI4AMR will provide the community with a new pipeline
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Shedding microvesicles as drug loaded Trojan horses (SMART) – an exploration of unique drug carriers using a versatile enzyme nano assay' (SMART).

assistant: **Innovation**

The development of efficient drug carriers is a major challenge in the field of drug delivery. Most existing delivery systems do not deliver their cargo efficiently or are rapidly inactivated by the immune system leading to unwanted side effects or no effect at all. Shedding microvesicles are cell-derived membrane vesicles constituting the body's own intercellular “shuttle service”. Due to their physiological constitution and stability in biological liquids these carriers hold great promise in fundamentally improving efficient drug delivery. The goal of this project is to assess the potential of shedding microvesicles as drug delivery vehicles by means of an innovative and broadly applicable assay for the detection of enzymes in living cells. Measurement of intracellular enzyme activity is crucial for the elucidation of molecular disease mechanisms and the development of efficient treatment strategies. The versatile enzyme assay is based on a novel nanoneedle system which allows parallel detection of intracellular enzyme activity. Nanoneedles are functionalized with different enzyme-specific, short fluorophore-labelled peptides. Once introduced into living cells, peptides will be cleaved intracellular releasing the fluorophore leading to a specific emission pattern depending on which intracellular enzymes are active. The assay constitutes a simple but broadly applicable technique for the measurement of any intracellular enzyme activity and can be adapted to monitor other cellular processes. In this regard, I propose to study shedding microvesicles and to develop them as unique drug loaded “Trojan horses” using the versatile enzyme nano assay. These microvesicles have not been explored in-depth for drug delivery purposes. Thus, this project will pave the way towards a be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The transcriptional regulation of cardiomyocyte polyploidization and its relevance in cardiac regeneration' (REACTIVA), addressing dissemination and exploitation.

assistant: **Impact**

The mammalian heart is a non-regenerative organ due to the extremely limited ability of fully differentiated cardiomyocytes (CMs) to proliferate. While neonatal hearts still contain mostly diploid CMs and regenerate efficiently, physiological postnatal CM polyploidization/hypertrophy ensures the contractile capacity of the adult myocardium but represents a roadblock to cardiac regeneration. Due to this limitation, diseases that provoke CM loss, like acute ischemia, frequently lead to heart failure. REACTIVA will establish a new strategy for heart regeneration based on the reactivation of a dormant endogenous mechanism, thereby achieving unprecedented advances in the field of cardiac regenerative biology. In mice, the proportion of adult diploid CMs (ADCs) correlates with regenerative ability, however, efforts to identify a molecular signature for ADCs have been unsuccessful, which has precluded exploring their roles in heart regeneration. Using an improved methodology for single-CM RNAseq, my group has identified a molecular signature of ADCs related to the fetal program and controlled by a single repressor transcription factor. This factor is specifically expressed in the polyploid CM population (PCM) and its inhibition in the postnatal mouse heart robustly increases ADC abundance and proliferative activity. Based on these findings, we propose that ADCs underlie a vestigial endogenous mechanism for adult mammalian heart renewal and that their stimulation will promote heart regeneration. REACTIVA will exploit our new findings on ADCs to 1) Fully characterize the ADC regulatory network, identifying factors to modulate it, 2) Identify and trace ADCs in the adult heart, defining their niches and contribution to renew and expand the CM population during heart homeostasis, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'BoostEuroTeQ: strengthening institutional transformations for responsible engineering education in Europe.'.

assistant: **Objectives**

The proposed project ‘BoostEuroTeQ’ aims at strengthening the research and innovation dimension of the EuroTeQ Engineering University. It strongly builds on synergies with its education-focused activities (funded by Erasmus+) to reinforce institutional change towards responsible research and innovation. It aims, in particular, at enabling individuals in technology value creation to interact with stakeholders of the wider society to ensure desirable and socially robust pathways for societal transformation. The work plan set out in BoostEuroTeQ strengthens and complements core parts of the EuroTeQ Engineering University. In a first pillar, the project will develop a concept for training learning professionals at universities and position them as key actors facilitating knowledge transfer and co-creative innovation between the university and the wider ecosystem. By defining a EuroTeQ upskilling strategy, it will help establish the partner institutions as constant companions in the lifelong learning journeys of engineers in Europe. This will enable the consortium to develop and implement an improved strategy for strengthening human capital and will re-inforce the cooperation with non-academic actors. In a second pillar, the project will analyse the EuroTeQ partners’ needs in terms of institutional strategies for reflexivity and develop a “EuroTeQ manifesto” for institutionalization. It will investigate how universities can engage with their surroundings by developing “learning networks” and will design an approach to evaluate the impact of co-creative education for innovation and understand its scalability. With that, BoostEuroTeQ will reinforce the impact of university research and innovation and build sustainable involvement and engagement with citizens and civil society.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Hydrological and hydrodynamic studies and predictions of the Caspian sea water level rise - impact of climate factors and man's activities' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Foreseen ResultsThe results obtained will be available, for planning of national and regional economies in the Caspian countries, for the design and operation of projects aimed at ecologically sound management of land and water resources in the Caspian sea itself, along its coastal fringe, and in its catchment area including the Volga river.The project partners are research institutes and private research company representing two NIS countries (Russia and Turkmenistan) ant three EU members ( France, Germany and United Kingdom) with a balanced input from NIS and EU.The projects results will be made available to a wide , international scientific community both through dissemination of the deliverables (reports) and via access to the data concerning the Caspian sea.A significant rise of the water level in the Caspian sea since 1978 was accompanied by inundation of large areas and by a rise in the water table, which resulted in a disastrous situation in the Caspian sea basin. Experts differ both about why this phenomenon has occurred and about the future course of events.The proposed project aims at the understanding of numerous hydro-meteorological factors involved, without which effective protection of the population on the coastal areas and of their environment are impossible. The project outlines multi-disciplinary approaches to :detailed water balance study of the Caspian sea;study of water exchange within the sea basin andthe hydrology of the Volga River (80 % of the inflow to the sea)These studies are directed at an elucidation of the reasons for the present sea level rise and an assessment of the most probable sea level trends over the next 10 to 20 years. The project will also consider the possible consequences of climate change and global warming. To achieve these
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Regional Comparative Advantage and Knowledge Based Entrepreneurship'.

assistant: **Concept**

This proposal addresses Topic 1 of Priority 7 of the Second Call. It aims at developing a comprehensive report on how societal, legal, and economic factors affect the patterns of regional economic growth and how Knowledge-Based Entrepreneurship (KBE) contributes to shifting patterns of regional comparative advantage and to regional growth and social cohesion.Our research will assess the links between societal, legal, and economic mechanisms and KBE at micro level, while studying the resulting regional dynamics and growth patterns at macro level. We will use a cross disciplinary approach to study KBE as a complex, multi-dimensional process. While theoretically grounded, our analysis will be mainly empirical and will provide a detailed blueprint for the implementation of the Green paper on Entrepreneurship.The project will have three main objectives:(1) Analyse the societal, legal, and economic factors that determine the forms and intensity of KBE. We will identify factors that affect risk-taking and entrepreneurship and create a conductive environment to the circulation of ideas within and across firms, fostering creative destruction. We will document how societal values, social capital, legal factors (e.g., intellectual property rights and corporate governance codes) and the provision of finance (especially through venture capital) affect KBE across European regions.(2) Analyse how KBE contributes to shifting patters of regional comparative advantage. We will assess the experiences of regions with different policies for the creation of human and social capital, for the elimination of barriers to entrepreneurship, for influencing the location decision of knowledge-based firms, and for technology transfers from established companies and universities to start-ups. We will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Safe Implementation of Innovative Nanoscience and Nanotechnology'.

assistant: **Concept**

The primary aim of the SIINN ERA-NET is to promote the rapid transfer of the results of nanoscience and nanotechnology (N&N) research into industrial application by helping to create reliable conditions. In order to strengthen the European Research Area and to coordinate N&N-related R&D work, the project has the aim of bringing together a broad network of ministries, funding agencies, academic and industrial institutions to create a sustainable transnational programme of joint R&D in N&N.The commercial application of nanomaterials (NMs) products is increasing rapidly, but one important question, the safety of NMs, still represents a barrier to their wide innovative use. Therefore the first priority of SIINN is to focus on developing a consolidated framework to address nano-related risks and the management of these risks for humans and the environment by investigating the toxicological behaviour of NMs.European R&D activities in N&N remain largely uncoordinated and fragmented, resulting in the sub-optimal use of available resources, such as human resources, research equipment and funding. Since available data on their toxicological behaviour is often scant, unreliable or contradictory, the SIINN Project will focus on ways of remedying this situation.After defining the criteria important for NM toxicology, the environmental health and safety (EHS) information currently available to Europe will be examined. Liaisons will strategically be established and maintained. They will network with organisations looking into the EHS of NMs within Europe and abroad with the aim of continually exchanging information with these. Available information will be examined for their reliability in respect of the assessment of the risks of NMs towards human health and to the environment and ma