RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'FROM TELOMERE CHROMATIN TO STEM CELL BIOLOGY' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Telomeres are ribonucleoprotein complexes at the ends of chromosomes that are essential for chromosome protection and genomic stability. Telomeres consist of tandem TTAGGG repeats bound to a 6-protein complex known as shelterin. More recently, telomeres have been also shown to contain long non-coding telomeric RNAs (TelRNAs or TERRAs), which are associated to the telomeric chromatin and have been proposed to be potential regulators of telomerase activity and telomere length. In addition, telomeric chromatin is enriched in epigenetic marks characteristic of constitutive heterochromatin, such as histone trimethylation (H3K9 and H4K20 tri-methylation) and DNA hypermethylation, which act as negative regulators of telomere length. Telomere length defects are associated to both cancer and aging processes, and have been recently shown to have a profound effect on stem cell behaviour. Here, we propose to determine the role of both genetic and epigenetic telomere regulators in cancer and aging by generating new mouse models. Finally, we will study the role of these factors in stem cell biology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The early sequestered germline of fungi - spatial distribution, mechanism and generality across the kingdom' to be submitted under Horizon Europe.

assistant: **Abstract**

The FunGerm-project aims to investigate the phenomenon of an early sequestered germline in the fungi. As of today, it is well known that in unitary animals the germline is defined early during development, while in fungi, plants, and other metazoans, the current dogma is that the germline is defined much later in development, meaning that mutations that have accumulated over growth can enter the germline. Recent, and yet unpublished, whole-genome-sequencing data in my group show the unexpected pattern of an early sequestration of the germline in the basidiomycete fungus Marasmius oreades, suggesting convergence in evolution of this key trait among major eukaryote lineages. M. oreades grows in fairy rings: circular, underground mycelia common in lawns and grasslands across the northern hemisphere. At the edge of the ring, the annual, sexual, fruiting bodies (mushrooms) develop from the mycelium. In recent years, we have developed the system as a natural, long-term evolution experiment to study the rise and fate of new mutations over sexual generations. With an ERC Advanced grant we will be able to use this system to fully explore the finding of an early sequestered germline, and also expand it to identify the breadth of occurrence across the fungal kingdom. Specifically, I propose to use a wide range of approaches and M. oreades as model organism to investigate: I) The spatial distribution of the somatic and germline cell-lines in mycelia, II) The mechanism determining and controlling germline segregation, and III) The mutation rate and spectra of the different cell lines. Furthermore, we aim to investigate IV) the prevalence of an early germline sequestration across basidiomycetes and other fungi. With the FunGerm-project we will thoroughly test if, and how, an early ge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Magnetically induced nano-forces in neuromuscular organoids for disease modeling' (2021-2027).

assistant: **Concept**

*Neuromuscular disorders, whose incidence and prevalence have increased over time have currently no cure, and understanding their pathological mechanisms remains challenging due to the lack of reliable human in vitro models. A groundbreaking approach involves human 3D trunk neuromuscular organoids (NMOs) that replicate the cellular diversity and the functional dynamics of the neuromuscular system. However, the absence of in vivo-like external stimulations leads to reduced contractions and prevent terminal maturation, restraining their applicability for studying long-term neuromuscular diseases. The primary goal of this project is to design innovative multi-disciplinary approaches to mimic in vivo mechanical and brain inputs and provide new paradigms for organoid generation. A new method will be developed to apply spatiotemporally controlled nano-forces within NMOs, with the aim of enhancing the maturation of both the neural and muscle tissue. Additionally, magnetically induced nano-forces will be exploited to guide the reconstruction of the corticospinal tract within newly generated cerebral-NMOs and integrate brain inputs. Cutting-edge imaging, optogenetics, and single-nucleus RNA sequencing will be used for in-depth characterization of the outcomes. The hypothesis is that these stimuli will significantly promote NMOs maturation, resulting in a more sophisticated model for neuromuscular disease research. As case-study, the enhanced NMOs will be applied to model and explore the complex pathological mechanisms of X-linked spinal and bulbar muscular atrophy (SBMA). Patient-derived nano-forced cerebral-NMOs will be generated to investigate the impact of SBMA on neuromuscular system and corticospinal tract. Supporting this project will enable the implementation of innovativ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Formability modelling of aluminium base PM alloys' under Fourth Framework.

assistant: **Concept**

Foreseen ResultsExpected achievements and benefits of the project are:A consistent description of material behaviour, which will establish a reference knowledge base;A proof of constitutive relations applicability for the target alloys;A better understanding of correlation between process parameters and the achievable product specifications in terms of resistance and quality will lead to a better production control;Improvement of product quality;Extension of the application area of PM products;Sensitizing the target industry branches about the feasibility of PM products production;Stimulation of the development of a scrap-free manufacturing method;Contribution towards development of a technology which can use recycled materials;Acceleration of modernization in a high technology sector.The exploitation of the project results will have a stimulating effect on the industry in the involved Central Europeancountries. The target group of industrial companies has got already several interested members, which have provided letters of endorsement.Powder metallurgy parts, a result of consolidation of metal powders into various shapes using pressed compaction of powder in precisely shaped metal dies, provides a means for generating low-cost parts for high-volume, small parts applications. CAB of powder metallurgy processes has been doing progresses by development of material models which allow the simulation of evolution in critical phases like compaction, sintering and forging. The Finite Element Method has established itself as the most efficient and flexible one. However, attention is continuously given to the characterization of the material properties at the micro- and macro-structural level, in order to make a realistic estimation of key parameters of the mathematical model,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'NEOdymium-Iron-Boron base materials, fabrication techniques and recycling solutions to HIghly REduce the consumption of Rare Earths in Permanent Magnets for Wind Energy Application' to be submitted under Horizon 2020.

assistant: **Abstract**

Regarding NdFeB PM technology for WT, it is still necessary to break through 3 important barriers: Strong dependence on China for supply and high price of REE present in PM, high difficulty of substitution of REE in PM, and technical and economic barriers that avoid establishing commercially viable, large-scale REE recycling framework.In this context, NEOHIRE main objective is to reduce the use of REE, and Co and Ga, in WTG. This objective is mainly achieved through the development of: a) New concept of bonded NdFeB magnets able to substitute the present state-of-the-art sintered magnets for WT, and b) New recycling techniques for these CRM from the future and current PM wastes. In this way, the EU external demand of REE and CRM for PM in WTG will be reduced in a 50%.The specific objectives are: i) To develop a new NdFeB material solution that reduces the use REE and CRM amount in PM for WTG (100% of HRE, 30% of LRE Nd/Pr, and 100% of CRM Co and Ga), ii) To increase the deliverable electric power in wind power electric generators from current 2.74 MW to 3.56 MW per 1Tn of REE owing to novel electric machine designs, iii) To research and develop two recycling processes to highly increase the CRM recycling rates in NdFeB PM wastes for sintered PM from current WT (increase from 0 to 70% the recovered Nd, separate 100% of Dy and recover 90% of Co) and novel Bonded NEOHIRE PM (recycling almost 95% of Nd), iv) To achieve an economic and technically feasible large-scale framework for NdFeB PM commercial recycling, and v) To ensure the economic and technical sustainability of NdFeB resin-bonded PM developed technologies.NEOHIRE will count on PM material RTD experts (CEIT, UOB), material recycling experts (UOB, KU LEUVEN), material characterisation RTD experts (CEIT, UPV, LBF),
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Assessment of the hazard and opportunities of using carbon nanotubes as a new nanocarrier for drug delivery in neural tissue', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

While neurodegenerative disorders and brain cancers increase in the population, current therapies have shown their limits. But thanks to recent advancements in nanosciences and nanotechnologies, new therapeutic opportunities are offered based on the development of nanoscale drug delivery systems. Among those, carbon nanotubes (CNT) have shown promising applications for therapy of a broad range of diseases because of their highly tunable abilities to transport different molecules and to penetrate cells. In this multidisciplinary project, we propose to use chemically functionalised CNT (f-CNT) as drug delivery systems for brain disease. However, since the knowledge concerning the interaction of CNT and the brain parenchyma is poor, the main goals of the project will be to define: (i) the potential hazard of using f-CNT in the brain and (ii) the pharmaceutical opportunities that these nanocarrier systems could offer. Our overall objective will be to identify critical parameters for the design/engineering of safe and effective carbon nanotubes based drug nanovectors for brain disease, with a special focus on the CNT surface functionalization. We will use both in vitro and in vivo studies to adresses these different questions.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Salt-free tanning for the production of high-tech uppeleather for military boots' (1998-2002) under Fifth Framework.

assistant: **Objectives**

This project will focus on the practical assessment of alternative high ph no- pickle" tanning processes. Aiming the eventual reduction of salt consunption and total dissolved solids (tds) concentration levels in tannery effluent. In particular, testing and optimisation of "no-pickle/no-deliming" chrome-alum tanning systems, as well as the development of an innovative "no-pickle" organic tanning process, for the production of upper leather for military boots manufacture will be undertaken. Currently available options for meeting thee fluent quality standards are restricted in replacement raw stock preservation systems and salt reduced use and recycling (tds reduction 20-30%). On the other hand, the viability of a prototype combined high-ph tanning system is far from being established as a best available cleaner technique for the commercial production of full and corrected grain upper leather with sufficient hydrothermal stability and hydrophobic character."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'SOLVING THE TECHNOLOGICAL PROBLEMS OF SHEEP CHEESE PRODUCTION' (TECHEESE) targeting Seventh Framework.

assistant: **Abstract**

The European sheep sector is involved in a structural decline intensified since 2006, that have encouraged the European Parliament to adopt a resolution proposing urgent actions to be taken to safeguard the sheep sector; which includes special support for research and development on both farm and product technical innovations. The sector is made up of three sub-sectors, particularly dairy product has technological problems during cheese elaboration causing lack of competitiveness. These problems during elaboration and ripening of cheese are caused by bacteria or fungi going inside the cheeses and widespread, it is then a topic of interest for SME AGs. The general objective of the TECHeese is to increase the competitiveness of the European sector by reducing the losses causes by undesirable microorganism. They will fight against the problem outsourcing research for two proposes: prevention and control. The preventive actions will be focused on development of feed formulations containing aromatic plants with antiseptic properties able to control specific microbial populations and to enhance sheep health and milk productivity. On the other hand, the control action will be establish on the development of a inspection systems based on low energy X-ray equipment in order to detect internal defects on the product before leaving factory and going to the market. SME AGs and SMEs will be directly involved in the research and demonstration activities within the project, since animals will be feed and cheese will be elaborated at their facilities. SME AGs from different sectors will cooperate with TECHeese project to tackle microbial contamination because the solution to this multifactor problem is not affordable by a single SME.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Liberating Programming' (LIBPR), addressing dissemination and exploitation.

assistant: **Impact**

We propose to provide the theoretical, algorithmic and methodological foundations, and build the supporting tools, to bring about a major, paradigmatic, revolutionary change in the way software and systems are programmed and executed, based on the idea of liberated programming, a sweeping extension of the scenario-based play-in/play-out approach to program design and execution that I and my group have done around the language of live sequence charts (LSCs). Play-in is a new way of software programming, combining the ideas of showing and teaching, instead of telling, relying on friendly advanced user interfaces, and using intuitive yet formal and expressive visual languages.  Play-out is a general name for the technologies of executing played-in programs using powerful tools such as model-checking and synthesis.   Our proposed work is divided into four main threads:  (1) play-in, the development of new languages and interaction techniques; (2) play-out, the development of new execution technologies; (3) domain specific adaptations and applications; and (4) integration and tools.  The play-in techniques proposed include the translation of systems requirements given in natural language into an executable artifact, the use of novel and dynamic human machine interaction techniques, relying on visual languages as target languages. The play-out execution methods proposed include the use of model-checking and synthesis algorithms, compilation, and execution environments that learn.  Domain specific applications proposed include web services, tactical simulators, embedded systems, and biological modeling.    Finally, we propose to build prototype tools that will allow the evaluation of the new technologies and their dissemination into the academic community and industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Direct cooling of dipolar molecules' to be submitted under Horizon 2020.

assistant: **Abstract**

Full quantum control of molecules has been an outstanding goal for decades. Cooling molecules provides a most promising answer to address this challenge. With recent progress in experimental quantum physics, such cooling is finally within reach. The aim of this project is to demonstrate the novel technique of molecular laser cooling for a gas of barium monofluoride molecules. Realizing a cold gas of these dipolar molecules will pave the way for a large number of novel and interdisciplinary applications ranging from few- and many-body physics to cold chemistry and tests of fundamental symmetries. The combination of this unique research project with the excellent environment for training, networking and research at the University of Stuttgart will ideally prepare the applicant, Dr. Tim Langen, for a future career as an independent research group leader.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Calcium-dependent Lectins in Human Pathogenic Infections: From Atomistic Understanding to Ligand Design' (CaLecLig).

assistant: **Innovation**

Lectins are proteins that bind saccharides, thus mediating cell-cell and cell-pathogen adhesion. They are therefore implicated in many devastating diseases (cancer, diabetes). The pharmaceutical industry had to leverage the remarkable progress in modern methodologies to cope with the enormous challenges of targeting lectins (flexible interactions involving calcium, multivalent ligands/multimeric receptors), producing a dozen of successful glycomimetic drugs (e.g. Tamiflu). To develop workflows comparable to traditional drug/target complexes, however, deep knowledge of lectin/ligand interactions must be gained. This project aims to fill this gap by determining the properties of Ca2+-dependent lectins, LecA/B and DC-SIGN, implicated in bacterial infections of cystic fibrosis patients and viral infections (HIV-1, Ebola), respectively. We will establish the microscopic view of Ca2+ binding to these lectins using advanced molecular dynamics (MD), verified by quantum mechanical (QM) calculations, isothermal titration calorimetry (ITC) and neutron crystallography. Then, we will work out protocol for predicting lectin-ligand binding modes and affinities using free-energy simulations, verified by NMR data. Finally, we will create a dynamic model of DC-SIGN tetramer by fitting to SAXS envelope and interpret multivalent binding types. The proposed project is novel and multidisciplinary. The applicant will acquire training in advanced experimental and computational techniques, which will re-enforce his career prospects in research and teaching. Conversely, he will transfer his knowledge of QM calculations to the host and partner institutions. This unique complementarity of competences will bring fundamental and practical understanding of lectin-ligand binding which will advance gly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unlocking the potential of laser 3D printing with ultrasound' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

If successful, this project will be a milestone in the development of 3D printing of metals by laser-directed energy deposition. The purpose of this project is to establish a scientific understanding of laser 3D printing of metals under the influence of ultrasound. A full description of this process will ensure the consistent performance of printed products for critical applications. The applicant will combine cutting-edge in situ synchrotron x-ray imaging and modelling approaches to characterise the development of the melt pool. Expected outcomes are likely to provide production guidance on laser 3D printing of metals with defect-free, highly refined grain structures that can be used to produce high value-added products. This research fellowship will enable the applicant to become an independent research group leader in the field of laser 3D printing.


**Keywords:** Additive manufacturing,  3D printing,  X-ray imaging