RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Pedestrian pre-crash reactions and their effects on crash outcomes'.

assistant: **Concept**

Under perceived risk such as an imminent pedestrian accident, basic human survival instinct can result in sudden involuntary reactions which eventually affect muscle activity, posture and location just before and during the pedestrian impact. Consequently, pedestrian kinematics, kinetics and injuries could differ from that of predicted using passive human surrogates such as cadaver, dummy or passive numerical models. This could have multiple consequences as the procedures currently used to design and evaluate the performance of safety systems are based on such passive responses. For example, it could lead to complete failure of a safety system due to an inadequate posture or to underestimation of an injury risk in lack of additional muscle forces. Furthermore, increase in frailty, functional disorders and decline in visual, cognitive, sensory and reactive abilities with aging could affect these reactions. This could be important to consider as the elder population is significant portion of pedestrian fatalities. Thus the objectives of this project are to investigate: (1) Is reaction of a subject placed in pedestrian accident situation able to modify the outcome of accident in terms of kinematics and injury risk? (2) Are age related changes in reaction behaviour (i.e. reaction time and muscle force capacity) important to consider in this context? This project will be separated in two major tasks i.e. experiment and computer simulations. Tests will be performed with human volunteers of two different age groups (elderly and young). Their postural and muscular reactions to sudden audio-visual perturbations will be captured. Tests will be done in a controlled lab setting using non-impacting simplified setups to avoid risk to volunteer. Test results will then be used as initi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biomass Mobilisation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The overall concept of BioMob is the development of research-driven clusters for biomass-mobilisation. The project, built on the outputs of a previous Altener-funded project, has a strong business focus and its ultimate goal is to see knowledge-based enterprises grow and thrive in the biomass sectors. This will support the sustainable use of biomass and the meeting of regions&apos; renewable energy targets. At a time of intense demand for renewable energy, real possibilities exist for the transformation of rural economies through the commercialisation of applied research in the mobilisation of biomass. The challenge is to identify appropriate synergies between rural regions, research themes and enterprise opportunity. The Biomob clusters, from DK, HU, BG and IRL, have widely varying biomass resources, levels of industrial development and research profiles. Biomob provides the opportunity for them to develop world-leading research outputs, in line with lead market principles. The work programme which will facilitate this includes specific actions for identifying the gaps between industrial demands and research capabilities, international benchmarking, regional action plans and JAP development, business plans for individual enterprises, development of regional funding proposals, the development of a replication model and an action to federate the clusters into the European Institute of Technology. Dissemination activities include 8 workshops, exchanges and mentoring activities, as well as brochures, CD-ROMs and a web site, which will remain for 2 years after project conclusion. The participants include the 13 partners, 4 regional user groups comprised of industry, research instates and development organisations, an international expert group and a European organisation fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Microscopic Image Processing, Analysis, Classification and Modelling Environment'.

assistant: **Concept**

The main objective of this exchange scheme is to establish a long-term research co-operation at an international level and to create new research opportunities in the emerging area of microscopic image processing. To this day, analysis of histology images of the human tissue biopsies remains the most reliable way of diagnosing and grading cancer. Our work on the computer-aided classification and rating of histology images is motivated by the fact that there is significant inter- and intra-rater variability in the grading and diagnosis of cancer from histology slides by human experts. Computational histopathology can assist the pathologists in making their grading and diagnosis reproducible, and by providing useful quantitative measures. Therefore, this new research will result in significant health benefits for patients. In this exchange programme, young researchers in Ph.D. programmes will be trained in a virtual lab consisting of facilities from Bilkent University (Turkey), The Ohio State University (USA), University of Warwick (U.K.), the University of Caen (France), and ITI-CERTH (Greece). As a result of this collaboration, image processing algorithms and software for images of follicular lymphoma will be developed, workshops will be organised, joint scientific papers will be published, including a proposal for a special issue in a respected scientific journal on the topic of microscopic image processing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High resolution dissection of non-coding determinants of disease' (B-ALLeles).

assistant: **Innovation**

While mutations at protein-coding sequences have been extensively characterized, the functional role of disease-associated non-coding variants remains largely elusive. In fact, germline non-coding variants are often associated with increased risk of childhood cancers. In B-cell derived acute lymphoblastic leukemia (B-ALL), the most common type of cancer in children, non-coding sequence variation at lineage-specific genes, such as IKZF1, GATA3 and CEBPE is associated with disease. Interestingly, the strongest risk factor maps at ARID5B, a DNA-binding protein described to promote the removal of repressive histone marks. Still, the role of ARID5B in leukemia and haematopoiesis remains largely uncharacterized. Thus, we hypothesize that non-coding variants associated with B-ALL affect the activity of distal regulatory elements, modulating the expression of ARID5B and other B-cell lineage-specific genes (objective 1). We further postulate that ARID5B promotes the de-repression of lineage-specific genes (objective 2), playing a crucial role in B-cell development and B-ALL initiation and progression (objective 3). To test these hypotheses, I will develop a novel CRISPR screen approach to dissect ARID5B enhancers at single nucleotide resolution (work package 1). I will use a combination of genomics and transcriptomics methods after acute and prolonged degradation of ARID5B to elucidate the molecular function of ARID5B in B-ALL (work package 2). Finally, I will use mouse models and focus on the physiological relevance of ARID5B in B-cell development and leukemia initiation and progression, in vivo. (work package 3). Together, I will dissect the role of non-coding variants at leukemia-associated loci, characterize the molecular function of ARID5B and elucidate the pathophysiologic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeting macrophage CD163 for treatment of non-alcoholic steatohepatitis' (NASH), addressing dissemination and exploitation.

assistant: **Impact**

Macrophages play a key role in inflammatory diseases. One of the goals of the TROJA ERC program has been to explore drug targeting via the haemoglobin scavenger receptor CD163, which has a high and exclusive expression in macrophages.  We have now developed new biodegradable anti-CD163 antibody-drug conjugates by linking drugs directly to anti-CD163 antibody and by encapsulating drugs in liposomes with anti-CD163 antibodies linked to the surface. The CD163-targeting technology has been proven in in vitro and in vivo models. A very promising line of results show that we by use of this technology in a rat inflammation model can show a fifty-fold increase in the potency of synthetic glucocorticoid (dexamethasone). At the same time we observe virtually no systemic effects, which are known to cause the serious glucocorticoids side effects such as bone mobilization, muscle mass loss, infections and metabolic alterations. We now want to investigate the effect of CD163-targeted glucocorticoid in a major inflammatory liver disease. Nonalcoholic steatohepatitis (NASH) is a common, often “silent” disease but anyway a major treat against general health.  A fatty liver is an important pathogenic factor in line with the fact that the steady increase in incidence of the disease correlates with changes in life style and obesity. The full-blown NASH with macrophage-driven inflammation and damage of liver tissue is a serious a condition with the risk of lethal liver cirrhosis. There is no current medical treatment of the condition The present approach of targeting the liver macrophages with 'safe' glucocorticoid may effectively dampen the acute inflammation and reduce mortality. The TROJA team expects to have PoC in the NASH indication within 12 month whereafter the project can be taken
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Firms in (a) Greener Economy' (FiGE).

assistant: **Concept**

The proposed project addresses the growing importance of stringent environmental regulations as tools to mitigate greenhouse gas (GHG) emissions and improve environmental performance. While there is broad consensus on the need for decarbonization, the economic impact and effectiveness of these policies remain debated. Building on Nunez-Rocha & Silberberger (2021), this project will develop environmental stringency indicators using legal documents from FAOLEX and ECOLEX, focusing on Germany and France. These countries, with distinct energy approaches—Germany favoring renewables and France prioritizing nuclear energy—provide a unique basis for comparative analysis, both operating under EU regulations. The first objective (O1) is to create indicators of environmental regulation stringency for Germany and France. This will enable an in-depth assessment of how stricter regulations impact firms and will also evaluate the effectiveness of these regulations in enhancing environmental performance. The second objective (O2) explores the effect of environmental regulations on trade, focusing on how stricter policies impact imports, exports, and the comparative advantage of firms. The research will investigate the existence of a Pollution Haven Effect, where stricter regulations may push industries to relocate abroad. The third objective (O3) examines the impact of regulatory stringency on firm productivity, considering both short-term compliance costs and long-term innovation gains. This analysis will explore how different industries respond to regulations and whether innovation offsets potential productivity losses. The project aims to provide policy recommendations to design regulations that balance environmental protection with economic stability, enhancing environmental perfor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of marker vaccines, companion diagnostic tests and improvement of epidemiological knowledge to facilitate control of rinderpest and peste des petits ruminants viruses' (2002-2006).

assistant: **Concept**

Rinderpest (RP) and peste des petits ruminants (PPR) control is considered a priority in the countries where the diseases are endemic (Africa, Middle East and West Asia). Because of their high mortality and high morbidity rates, RP and PPR are dreaded animal diseases included in the list A of the Office International des Epizooties, list of dangerous animal pathogens where extremely contagious animal diseases of high economic importance are grouped. Effective control of RP and PPR by vaccination, through international funding, mainly by the EU, contributes to increasing and sustaining livestock and ensures world food security. In the present proposal, the first objective is to develop marker vaccines capable of preventing RP and PPR infections and also companion diagnostic tests to differentiate between infected and vaccinated animals. This differentiation is of major importance for eradication programmes because it would allow more precise targeting of vaccination while serosurveillance of the disease could be maintained through the use of companion diagnostic tests. This would allow for a quicker lifting of control measures. Through reverse genetics technology it is also aimed to improve the quality of these marker vaccines derived from current attenuated strains. Another objective of the proposal is to use improved epidemiological information systems for a better analysis of the current situation for rinderpest and PPR and for predicting the impact of vaccination strategies on the control of the two diseases. Thus the expected outputs from this proposal will give additional support to some existing EU developing country programmes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Study of Strongly Interacting Matter' in the context of a Sixth Framework call.

assistant: **Objectives**

The Project titled: Study of strongly interacting matter" promotes the access to nine European Research Infrastructures (RI), and covers seven Networking Activities and twelve Joint Research Activities (JRA). The Project originates from a common initiative of more than 2000 European scientists working in the field of Hadron Physics. Hadron physics deals with the study of strongly interacting particles (hadrons), as the proton and the pion. Hadrons are composed of quarks and gluons. Their interaction is described by Quantum Chromo Dynamics, the theory of the strong force. Hadrons form more complex systems, in particular atomic. Under extreme conditions of pressure and temperature hadrons may lose their identity and dissolve into a new state of matter similar to the primordial matter of the early Universe. The Networking Activities are related to the organisation of experimental and theoretical collaborative work concerning both ongoing activities at present Research Infrastructures and planned experiments at future facilities. In hadron physics, in fact, the close interaction between experimentalists and theoreticians is of paramount importance (therefore, three of the Networking Activities are theoretical ones). The Joint Research Activities concentrate on technological innovations for present and future experiments at the participating RIs. Applications in material science, medicine and information technology will be pursued vigorously. The main objective of this Project is to strengthen the European Research Area by promoting access to the leading Hadron Physics RIs in Europe and by improving their performances. This will be achieved by developing new methods and experimental tools in the JRAs and by Networking Activities, unifying, for the first time, three previousl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Effects of Joint and Multimodal Remembering on Collaborative Learning' (DISTRIBUTEDLEARNING).

assistant: **Concept**

Often remembering in learning activities is supported by the social and material environment in which the specific activities unfold. However, so far, little research has been done to integrate the ways in which joint remembering supports collaborative learning tasks in social interactions with other people by means of verbal resources (e.g. lexical and syntactic alignment) with the embodied (e.g. using hands to give directions) and distributed (e.g. relying on tools such as pencil and paper to solve mathematical operations) nature of these practices in relation to educational and work settings. Hence, by paying particular attention to role of joint remembering in multimodal interactions related to educational and work environment, the general aims of this project are: i) to examine how collaborative learning is grounded in successful joint remembering processes; and ii) to explore the central role that the integration of linguistic, embodied, social and material resources plays in collaborative learning activities, by transforming them into distributed practices across space and time. The results of this project will constitute a first step towards a more ecologically valid framework on collaborative remembering and distributed learning, which then could be tested by psychologists, and learning and communication scientists in natural as well as experimental settings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'HOmogenous heating of Thermal FlUids based on Metamaterials'.

assistant: **Concept**

HOTFUM aims to demonstrate the feasibility of developing an innovative Power-to-Heat & Thermal Energy Storage (P2H & TES) interconnected technology. The main idea is that a novel power-to-heat approach can induce uniform heating in heat transfer fluids (HTFs), which are used for both heat transfer and TES.Electricity can be converted into heat using technologies like resistive heating, which directly heats HTFs. This method can lead to uneven temperature distribution, causing hot spots that may damage the HTF and reduce the lifespan of the heating elements. Both P2H & TES systems, face similar challenges due to non-uniform heating of HTFs. HOTFUM offers a novel approach by exploring the use of nanoparticles (NPs) suspended in different HTFs like water, synthetic oils, ionic liquids, and molten salts. The objective is to demonstrate a novel power-to-heat approach for heating these fluids.HOTFUM is strategically designed to take advantage of the researcher´s expertise in nanofluids for TES systems, the advanced characterization techniques available at CIIAE, the strong background of the supervisor in the field of TES. The project includes a secondment in a group specialized in nanotechnology and a placement in a SME focused in the development of NPs.


**Keywords:** Nanomagnetism, magnetism and strongly correlated systems, new materials: oxides, alloys, composite, organic-inorganic hybrid, nanoparticles, renewable energy sources