RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Large Scale Silicon Photonics Matrix for Low Power and Low Cost Data Centers'.

assistant: **Objectives**

Cloud storage and computing, big data analytics and social media are driving the need for higher bandwidth communications in data centres (DCs). Concurrently, disaggregation and virtualization trends in the DC are forcing the traffic to be between servers and storage elements in the east-west direction. These changes require massive switching capabilities from the discrete switch elements. However, the technology is rapidly reaching a limit. The result is a multi-layered DC topology with high power consumption and long latency. The L3MATRIX project provides novel technological innovations in the fields of silicon photonics (SiP) and 3D device integration. The project will develop a novel SiP matrix with a scale larger than any similar device with more than 100 modulators on a single chip and will integrate embedded laser sources with a logic chip thus breaking the limitations on the bandwidth-distance product. Use of embedded laser sources and integration with a full logic CMOS chip are innovative steps that will have a profound effect on the European market as these technologies will make a noticeable change in the power consumption, performance and cost of DCs. A novel approach will be used with embedded III-V sources on the SOI substrate which will eliminate the need to use an external light source for the modulators. L3MATRIX provides a new method of building switching elements that are both high radix and have an extended bandwidth of 25 Gb/s in single mode fibres and waveguides with low latency.  The power consumption of DC networks built with these devices is 10-fold lower compared to the conventional technology. The outcome of this approach is that large networks, in the Pb/s scale can be built as a single stage, non-blocking network. The single mode nature of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Inner models and infinite computations' (IMIC) targeting Horizon 2020.

assistant: **Abstract**

This proposal is in mathematical logic. It aims to study interactions between set theory and computability. More specifically, we want to apply techniques from inner model theory to computability and randomness. The development of modern set theory began with Paul Cohen's solution of Hilbert's first problem in 1964. Since then, set theory has been used to solve important problems in various areas of mathematics. Descriptive set theory studies definable sets of reals, for instance Borel and analytic sets, and computability studies computable functions and its higher analogues. We propose to develop applications of inner model theory in computability. Inner model theory is a major field of set theory  which was pursued for instance by Ronald Jensen (recipient of the AMS Steel prize 2003 and Hausdorff medal 2015) and Hugh Woodin (recipient of the Hausdorff medal 2013).  A major aim of this field is to determine the logical strength of theories. Recently, several new approaches for constructions of inner models have been studied, for example via strong logics by Menachem Magidor and Jouko Väänänen. We propose to follow this line of research and to study models constructed via ideas from infinite computation related to work of Joel David Hamkins and Philip Welch. We further propose to apply inner model theory and descriptive set theory to study random sequences. Algorithmic randomness is a central field in computability with connections to theoretical computer science, that has been studied intensively, for instance by Ted Slaman and Andre Nies. We aim to solve problems in the higher generalizations of algorithmic randomness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Characterisation of glia and their precursors in the human brain.' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

This proposal aims to generate unbiased estimates of the total numbers of astrocytes, oligodendrocytes, imbroglio and their precursor cells in the normal developing and adult human brain, and to study the ontogenesis and differentiation of the supporting atrocities, the myelin-forming oligodendrocytes and the immunocompetent imbroglio cells. Additionally, the functionally very important process of mediation of axons will be studied quantitatively in children.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'HOT III-V  II-VI Focal Plane Arrays for Space Applications in the Upper SWIR Band' to be submitted under Horizon 2020.

assistant: **Abstract**

Missions from space for high-resolution earth observation (including greenhouse gases monitoring) require optical sensors covering both Visible channels and the Short Wavelength InfraRed band (SWIR). For SWIR optical sensors, the current approach in Europe is HgCdTe N/P sensors cooled to cryogenic temperature. SWIRup is aiming at developing an alternative photosensitive material to current HgCdTe N/P sensors. It will focus on InGaAs/GaAsSb super-lattice lattice matched to InP substrate, named III-V. The objective is to push the cut off wavelength up to 2,5µm (currently limited to 1,7) adding SWIR bands to the common VISIBLE channels generally proposed on instruments dedicated to earth observation from space. The SWIRup sensor technologies will also provide alternatives to HgCdTe N/P detectors for commercial applications in the SWIR spectral range, such as hyperspectral imaging systems (for airborne, field applications) and Lidar (or active imaging applications). The 2nd objective is to achieve high operating temperature for focal plane arrays, to be the closest possible to room temperature (230 to 290K) compared to the typical 200-210K for current HgCdTe detectors. This will eliminate cryogenic cooling, improving miniaturization, power reduction, efficiency and versatility of the optical payloads, all of which could provide room for increased functionality. The SWIRup technology will be compared to the current reference II-VI technology which is the HgCdTe P/N material, leading to a technology prioritization by type of application, as each material has its own advantages. This II-VI material, already optimized for cooled astronomical application, will be improved to work at higher temperature. The proposal includes the manufacturing and tests of 2D arrays with sensitive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Explanation in Online Help and Offline Training Based on Continuous Simulation' to be submitted under Fourth Framework.

assistant: **Abstract**

The main outcomes of the research activities of the EXTRAS project are the generic knowledge framework, and an extensive amount of the software produced which has allowed further steps in developing explanation systems. Explanation systems that are quite difficult, if not impossible, to obtain by other means. The project has had three major outcomes that can be used for explanation.A methodology which will allow the use of intelligent simulation systems of on-line decision support and off-line training.A set of generic software tools for interaction and explanation that can be combined with most existing simulation systems for developing future EXRAS systems;The application of such toolkit to one important industrial process which is the power distribution substations.Generally speaking, additional effort would be necessary in some methodological aspects, such as the multiple models switching strategy, as well as in the software toolkit to improve the robustness, reliability and integration of the whole system to allow a proper industrial exploitation. However, the system as it is, can be definitely profitable and the experience gained in the framework of the project will allow developing future simulator-based explanation systems in a cost-effective way.The results of the applications are:The Fossil Fuel Power Plant Application (FFPPA), an ISS for off-line training of power plants control room operators by means of real-time simulators. The training goal is the assessment and the improvement of the personnel capabilities related to the plant operation, mainly in usual and faulty. FFPA can constitute an effective support to the current training activity carried out by the Specialist Training Service of ENEL: it can be used both as an exercising tool for in-house trainin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecules Inhibiting Translation in Cancer cells' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

YB-1 is one of the major mRNA binding proteins and a master regulator of translation in cancer cells. It has been recently considered as a therapeutic target for the treatment of cancer and drug-resistant cancer. However, no small molecules with high affinity and specificity against YB-1 have been proposed so far, and the structural data essential to interrogate their relevance are missing. Understanding the function of translation regulation systems in order to design drug candidates is a very delicate procedure that requires a high level of accuracy and state-of-the-art techniques. Based on a promising preliminary finding of an active compound, we will focus in depth on studying the inhibition mechanism of YB-1 in order to help design new anti-cancer drugs able to overcome drug resistance. The research approach developed in this context aims to use in synergy advanced computational and experimental techniques while overcoming all limitations in a concerted way. This work is concerned with providing a sufficiently accurate computational model that is computationally efficient, specific experimental data and combining them with data mining techniques, for a molecular-level characterization of the inhibition dynamics and thermodynamics. This project is based on a multidisciplinary approach that requires knowledge of biology, biochemistry, physical chemistry, theoretical chemistry and bioinformatics in order to contribute to the medicine of the future.


**Keywords:** YB-1, Cancer, Drug Design, NMR Spectroscopy, Microtubule Bench, Molecular Dynamics, Free Energy Simulations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Engineering substrate-based inhibitors of Plasmodium SUB1, a potential target for Malaria treatment.'.

assistant: **Concept**

The Researcher AK Puszko will be in charge of the development of peptidase inhibitors with potential interest in the treatment of Malaria.Malaria is the most important human parasitic disease and multi-resistant parasites seriously threaten its treatment and control. The situation strengthens the constant need to fuel the antimalarials pipeline with candidates active on new targets, expressed at essential stages of Plasmodium.  The egress of merozoites from infected host cells is such a pivotal step that strictly depends upon parasite proteases, including a novel highly promising target, the Plasmodium-specific subtilisin SUB1, for which no useful inhibitor has been discovered yet. SUB1 plays a key role in the egress from hepatocytes and erythrocytes, including for male gametes (involved in parasite’s transmission via the Anopheles vector), indicating that an inhibitor would have both prophylactic and therapeutic value and obey to most severe WHO’s criteria of future anti-malarials, i.e. targeting all stages of parasite life cycle. Based on Hosts’ promising results, including the resolution of crystallographic structures of SUB1-inhibitor complexes, the SUBUN project aims at identifying highly potent and selective SUB1 inhibitors, active against parasite growth in vitro and in vivo. Such innovative pre-lead candidate(s) will be patented before results dissemination within academia, industry and to wider audience.This project will combine expertise in molecular design, medicinal chemistry, biochemistry, structural biology and parasitology. In this multidisciplinary context, the project will benefit AK Puszko who will gain extensive knowledge in new fields well established in the Host and secondment Host laboratories. This, together with scientific and transferable traini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Decoding the DNA damage signalling in C. elegans by proteomic analyses of ADP-ribosylation' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Preservation of genome integrity and stability is critical for survival and propagation of individuals and species. Organisms have thus evolved rapid and efficient mechanisms -collectively termed the DNA damage response (DDR)- to combat threats posed by DNA damage. Among these, the post-translational modification (PTM) ADP-ribosylation (ADPR) plays a decisive role in effective DDR. Although much is known about the relevance of ADPR upon DNA injury, the underlying molecular mechanisms are still poorly understood and no systematic, unbiased proteome-wide study to determine ADPR targets in vivo has been conducted to date. The most challenging and innovative goal of this proposal is to profile in vivo ADP-ribosylated peptides during DDR in the well-established model system Caenorhabditis elegans by the combined application of advanced proteomic approaches. I will develop novel enrichment strategies that will allow me to confidently map for the first time all the sites of ADPR throughout the C. elegans proteome. I will take advantage of SILAN technology, which allows stable isotope labelling in C. elegans, to determine the quantitative profiles of thousands of ADPR sites during DDR. By bioinformatic analysis, I will select candidate proteins for further investigation of the biological role of DNA damage-induced ADPR. I will then test the biological impact of ADPR of these candidates through site-specific mutation of their identified modification sites. Finally, I will perform biochemical, molecular and functional experiments to study how ADPR alters the activity of these proteins and thereby characterize the mode of ADPR action. Understanding the regulatory networks that underlie such a complex biological process at the organism level will provide new insights for improved t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Novel bioresorbable scaffolds and culture methods for cartilage tissue engineering (SCAFCART)'.

assistant: **Concept**

Tissue engineering approaches have been successfully applied to the treatment of injured particular cartilage. However, problems encountered include the poor quality of regenerated tissue and difficulty in integrating engineered cartilage at the clinical site. This RTD project takes a problem solving approach to improve significantly the quality of tissue engineered cartilage by combining optimized scaffolds with advanced culture methods. Integration at the surgical site will be achieved by generating an osteochondral construct. The latter will also be applied to extend tissue engineering to the treatment of degenerative joint disease and facial cartilage deformity. This RTD project will set new high standards for the biological quality of engineered human tissues to ensure that the European tissue engineering industry is competitive on a world stage, improving quality of life while stimulating economic development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Spectroscopy@IKU - Manipulating and Characterizing Molecular Architectures: From Isolated Molecules to Molecular Crystals', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Spectroscopy@IKU aims to strengthen Molecular Physics, Chemistry and Materials Sciences at Istanbul Kultur University (IKU), by establishing a strong, internationally competitive research team dedicated to molecular spectroscopy at the IKU Faculty of Sciences and Letters. The team will be led by Prof. Rui Fausto (ERA Chair holder), a world-leading scientist in the field. A new research infrastructure dedicated to spectroscopy will be created, supporting the ERA Chair team and serving as a spectroscopy platform for other IKU research groups. Additionally, it will provide spectroscopy services to external users, from both academy and industry. The ERA-chair research team will engage in training young researchers and post-graduate students, contribute to the academic activities of IKU on spectroscopy, and participate actively in outreaching actions. All activities will follow the principle of free circulation of knowledge and expertise, aligning with ERA priorities. Research will focus on two main areas sharing the need for precise molecular structure manipulation and characterization: (i) structure and reactivity of atmospheric and astrophysically relevant molecules, and (ii) polymorphism in molecular crystals and cocrystals. The first subject centers on the laboratory study of isolated molecules and small aggregates, addressing fundamental chemistry and physics in Earth's atmosphere and space, through exploration of new avenues of chemical reactivity and their underneath physical processes, such as reactions resulting from vibrational excitation of molecules or taking place via quantum mechanical tunneling, two subjects the ERA-Chair holder has been pioneering. The second main subject is a hot topic in materials sciences and one of the most crucial subjects for pharmaceu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'INNOVATION RELAY CENTER POLAND NORTH-EAST' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The proposed Innovation Relay Centre Poland North-East (NEPIRC) has been created by the following organisations: University Technology Transfer Centre of Warsaw University(UTTC)-Coordinator, University of Warmia and Mazury in Olsztyn(UWM),Technology Transfer Centre of East(TTCoE) of University of Bialystok, Lublin Technology Transfer Centre(LCTT) of Lublin Technical University and CASE-Advisors Ltd.(CASE).NEPIRC covers three less-favoured regions of Poland: warminsko-mazurskie, podlaskie and lubelskie. Their GDP per capita is far less then 0.7-0.75 of average in Poland. Consortium is built in two dimensions: regional and transregional. In regional dimension three regional partners UWM, TTCoE and LCTT will perform IRC core activity in their regions of responsibility. For UWM it is warminsko-mazurskie, for TTCoE it is podlaskie and for LCTT it is lubelskie. In transregional dimension activity of UTTC and CASE is proposed to support insufficient regional resources. Those will support partners with high quality services for their clients, focused on knowledge and know-how transfer. NEPIRC strategic objective is to provide cost-effective services that promote transnational technology transfer (TTT) co-operation which responds to specific regional needs. This strategic objective will be achieved through 3 operational objectives:1.Enhancement SMEs competitiveness by supporting inward TTT focused on regional specific technology needs.2.Identifying exploitable technologies and research in the NEPIRC regions and promoting them in Europe.3.Strengthening regional partners linking them with IRC network to adopt best European practices in providing TTT services.Objectives will be realized through activities in 9 Workpackages. The most important expected results of the project are:·25