RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Prototyping Internet Lot of Things Software' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Virtual platforms have been mainly used to support anticipation of embedded software (eSW) development of very complex System on Chip (SoC) or for Software-based functional validation of complex IP. The explosion of the number of connected things change the complexity paradigm: the challenge is now to manage hundreds of distributed platforms (SoCs or boards) that include processors, sensors, MEMs and communication devices.  Using physical board to prototype each of these platforms to verify the overall system behaviour is too expensive and not scalable for system providers. System integrators require a scalable solution for system prototyping. The use of virtual platforms appears to be the answer, but they lack tools to deploy and integrate this solution in their prototyping flow.  According to state of the art and technical analysis with CEA and Fraunhofer, no such solution is available today; as a long time provider of hardware integration platform, Magillem has been a pioneer in design environment software for SoC integration and SoC virtual platform since its early days and believe to be in a unique position to introduce a very innovative solution for IoT enablement. By using PILoTS, European leading system integrators, as well as suppliers of MEMS, micro-controllers, connected systems would save time and cost, during design, verification and certification, and vastly improve their competitiveness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Biophysical Genetic Design Automation Technology' (PLATE).

assistant: **Concept**

Advances in our capabilities to program, synthesize and modify DNA has led to a surge in the field of synthetic biology. Various gene circuits have been proposed and designed in various organisms for application domains ranging from biomedicine over biotechnology to biomaterials. Our current bottleneck is not anymore our ability to program and synthesize custom DNA, but rather our ability to design regulatory circuit that realize the desired functionality and operate reliably in a specific target host cell or in vitro systems. The largest hurdle that we identify is the context-dependency of synthetic circuits, i.e., their perturbation by other molecular factors belonging to the host cell. Given the complexity of these molecular systems, current design approaches that rely on trial-and-error will not be able to produce meaningful designs in a reliable, fast and systematic manner at the scale required for industrial applications. Although genetic design automation tools are available to overcome this unsatisfactory state of affairs their practical impact have been limited. This is due to the fact that the used models are not accurate enough, in particular, they cannot predict reliably the performance of a circuit design when operating within a host cell. The main reason for this limited predictive power is that models do not take into account the named context-dependency of circuits. The current project PLATE takes on this challenge and leverages methods developed within the ERC Project CONSYN that allow for accurate modeling of context-effects through the use of detailed biophysical models. The aim of PLATE is to integrate all those computational methods into a coherent design environment for the synthetic biology researcher in academia and in industry. The resulting PLA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Innovative Strategies for High-Grade Material Recovery from Construction and Demolition Waste', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The main goal of the IRCOW project is to develop and validate upgraded technological solutions to achieve an efficient material recovery from C&D waste by considering a life cycle perspective.The innovation beyond the state-of-the-art will focus on:1.Developing new approaches and models aimed at raising the rate of reuse components.2.Developing and adapting recycling technology with the overall purpose of improving the quality of C&D recycled materials: recycled aggregates, wood, plastics, granular gypsum from mixed streams and emerging waste materials.3.Developing high grade construction products by using C&D recycled materials; not only those related to the stony fraction, but also the other fractions where there is currently a strong knowledge gap.4.Demonstrating results under real conditions with the aim of providing potential stakeholders with information on the global performance.5.Setting the basis for specific European policies on C&D waste aiming at fostering a high and efficient level of material recovery.To accomplish IRCOW objectives, the project is structured into 7 work packages and 5 in-field case studies. Three of the work packages focus on the development of new management schemes, separation technologies and products that are needed to significantly increase the reuse and recycling rates of C&W waste in the EU. The outcomes of the three technological work packages will be assessed and validated from an economic, environmental and toxicological point of view, by using both Life Cycle Assessment tools and case studies throughout Europe.The involvement of industrial stakeholders (both industrial companies and associations from the construction and recycling sector), and national and regional authorities ensures the relevance and applicability of the proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Nutrient redistribution by mammals as a key mechanism for ecosystem restoration' in the context of a Horizon Europe call.

assistant: **Objectives**

Declining soil fertility represents one of humanity’s major challenges in the 21st century. In the past, large vertebrate animals played a crucial role in transporting nutrients between ecosystems, supporting a more fertile planet. Today, however, species extinctions, diminished population abundances and constraints on animal movement have reduced animal-mediated nutrient transport by >90% compared to the late-Pleistocene. In contrast, anthropogenic use of certain nutrients (nitrogen [N], phosphorus [P] and potassium [K]) vastly exceeds planetary boundaries. Consequently, some areas of the world experience excessive nutrient pollution and others nutrient depletion. Agricultural abandonment trajectories provide opportunities for large-scale ecosystem restoration, including rewilding of large vertebrates. However, where humans have altered nutrient geographies, redistribution by wild animals may have unintended consequences for nearby ecosystems, including to plant productivity, carrying capacity, carbon storage and endemic competitive advantages. Consequently, changes to either anthropogenic nutrient loading or to animal dynamics during ecosystem restoration projects can have far-reaching implications.RE-NOURISH will develop an agent-based modelling framework that quantifies the redistribution of multiple nutrients across landscapes by different guilds of large mammals. Crucially, this model will include the direct and indirect influences of predators – an essential, but often overlooked aspect of nutrient redistribution in terrestrial landscapes. The RE-NOURISH framework will then be applied to two restoration case studies in (i) nutrient-deficient and (ii) nutrient-polluted environments. This transformative approach will directly help conservation practitioners achieve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quantifying Evolution: a platform for the synthetic evolution of molecular ecosystems.' (Q-EVO).

assistant: **Concept**

Among the fundamental processes governing Nature, evolution is one of the most thoroughlAmong the fundamental processes governing Nature, evolution is one of the most thoroughly described and less formalized. The grand goal of describing evolution via clean universal laws is made difficult by the inherent complexity of both the biological systems and the available experimental models, which generally involve a large number of potentially relevant variables of difficult quantification. This project is built around the Affinity-based DNA Synthetic Evolution (ADSE) platform, an experimental strategy to generate and study evolution at a molecular level that enables full quantitative description of the eco-evolutionary processes. ADSE is inspired by the in-vitro molecular selection protocol “SELEX” and enables observing the evolution across generations of large populations of DNA oligomers whose identity is given by their sequence. The key innovation is that here evolutionary mechanisms and ecological interactions (selection of the fittest, resource gathering capacity, parasitism, mutualism etc…) are given by molecular interactions based on DNA-DNA hybridization, a process that is well known and predictable from sequences. Q-EVO is based on a combination of ADSE with an innovative array-based biosensor, approaches of data science and notions of theoretical ecology. Q-EVO aims at providing a (still missing) quantitative description of the key concepts of fitness and speciation, and of the relationship between a given environment and the evolution of its ecosystem. I propose a program capable to produce hundreds of parallel evolutions for tens of generations exploring a vast variety of conditions. Raw data, formed by hundreds of millions of reads, will be analysed to follow po
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Extensive UNIfied-domain SimulatiON of the human voice', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Everyone needs their voice, and speech has a pivotal function in modern society. A detailed, working model of the voice would contribute to the human atlas and would find profound applications in fields such as speech technology, medical research, pedagogy, linguistics and the arts. But the physics are very intricate: we make the sounds of speech, song and emotions using multiple mechanisms; and these are under exquisite control, through muscle activation patterns acquired from years of training. Physically, voice involves complex interactions between laminar and  turbulent airflow; vibrating, deforming, colliding elastic solids; and sound waves resonating in a contorting duct. So far, these mechanisms have had to be studied one at a time, using disparate tools and often gross approxi¬mat¬ions, for each of the subproblems. Now, advances in computing techniques suggest the possibility of simulating the entire voice organ, including its biomechanics and aeroacoustics, in a unified numerical domain. This major computational challenge would bring research and education much closer to reality. In the EUNISON project, we seek to build a new voice simulator that is based on physical first principles to an unprecedented degree. From given inputs, representing topology or muscle activations or phonemes, it will render the 3-D physics of the voice, including of course its acoustic output. This will give important insights into how the voice works, and how it fails. The goal is not a speech synthesis system, but rather a voice simulation engine, with many applications; given the right controls and enough computer time, it could be made to speak in any language, or sing in any style. The model will be operable on-line, as a reference and a platform for others to exploit in further
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DISTRIBUTED TEMPERATURE SENSOR' in the context of a Fourth Framework call.

assistant: **Objectives**

To determine that a distributed fibre optic temperature sensor (DTS) used as an early warning fire/heat detector can give an improved system for fire detection on offshore oil/gas production platforms. Critical factors to be tested out will be the long term reliability of the system in such environments including the ability of the fibre optic sensing cable to withstand the tough North Sea weather conditions and rough working environment.The trials was carried out on the Heimdal platform which is operated by ELF Petroleum Norge. The trial started up on 14 November 1996 and was terminated 3 December 1997. The performance of the system was monitored continuously and any alarm event recorded. In addition, monthly tests were made to check performance of alarm functions, cable loss and temperature accuracy. In general the demonstration was successful. It gave much useful experience and information for later actual installations. The software used for identifying a possible fire situation worked well, but some problems were also experienced. The DTS-unit did once in a while make erroneous temperature measurements. This problem appears to have been solved in the newest version of the DTS.The DTS based system is meant to replace the heat detectors presently in use. One length of fibre cable will be equivalent to a number of point detectors.This technology is to be tested out on an offshore oil/gas platform to find out if it will give an improved heat detection system for early warning fire alarm systems. In this context the long term reliability of the system in such an environment including the ability of the fibre optic sensing cable to withstand the tough North Sea weather conditions, the corrosive sea air, and the rough working environment on a platform.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Hochschild cohomology, non-commutative deformations and mirror symmetry' (HHNCDMIR).

assistant: **Concept**

Our research programme addresses several interesting current issues in non-commutative algebraic geometry, and important links with symplectic geometry and algebraic topology. Non-commutative algebraic geometry is concerned with the study of algebraic objects in geometric ways. One of the basic philosophies is that, in analogy with (derived) categories of (quasi-)coherent sheaves over schemes and (derived) module categories, non-commutative spaces can be represented by suitable abelian or triangulated categories. This point of view has proven extremely useful in non-commutative algebra, algebraic geometry and more recently in string theory thanks to the Homological Mirror Symmetry conjecture. One of our main aims is to set up a deformation framework for non-commutative spaces represented by ""enhanced"" triangulated categories, encompassing both the non-commutative schemes represented by derived abelian categories and the derived-affine spaces, represented by dg algebras. This framework should clarify and resolve some of the important problems known to exist in the deformation theory of derived-affine spaces. It should moreover be applicable to Fukaya-type categories, and yield a new way of proving and interpreting instances of ""deformed mirror symmetry"". This theory will be developed in interaction with concrete applications of the abelian deformation theory developed in our earlier work, and with the development of new decomposition and comparison techniques for Hochschild cohomology. By understanding the links between the different theories and fields of application, we aim to achieve an interdisciplinary understanding of non-commutative spaces using abelian and triangulated structures.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'MARPOL RULES AND SHIP GENERATED WASTE' in the context of a Fourth Framework call.

assistant: **Objectives**

The project can be broken down into three major areas of research :* the collection and synthesis of data on waste and pollution resulting from routine maritime operations ;* the design of a model to describe environmental changes resulting from improved technologies and the widening application of the MARPOL rules ;* the definition and resting of possible solutions for the improved management and treatment of ship generated waste.The results of the data synthesis will be used as the starting point to devise a model to characterise the environmental changes resulting from improved technologies and the widening application of MARPOLrules. Using the model this programme will attempt to establish a relationship between improvement and cost and to suggest realistic objectives at reasonable cost.The results from the data analysis exercise will also be used to assist in drawing up the specification for commercially viable improved waste management systems. A review of current practice will provide the baseline for this phase of the research programme. Methods of exploitation of these systems will be put forward.In detail the objectives are :* To analyse operational waste produced by ships* To assess the impact of MARPOL rules on the port environment in Europe* To develop a conceptual model to investigate the indicators in the natural environment which are affected by pollution from ships and the changes in these indicators as a result of MARPOL* To implement the model to simulate the functions and responses of the system* To identify the constraints on possible improved waste management systems* To define, evaluate and test possible solutions for the improved treatment and management of ship generated waste* To propose policy guidelines %
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Characterisation of chiral gels by capillary electrophoresis'.

assistant: **Objectives**

The incorporation of various chiral molecules in hydrophobically modified polymeric gels will constitute the first step of the study. Depending on the type of interactions (electrostatic, hydrophobic) governing the partition of these molecules in the gels, along with the ability of micellar aggregates to be present in the gel lattices, the separation of ionic and neutral optical isomers will be studied and modelled. The understanding of the separation process will be carried out as a function of the usual operating parameters of Capillary Electrophoresis The second approach of the study will consists in the synthesis and the characterisation of chirally modified-gels synthesised from the copolymerisation of modified and unmodified units. The ability of the synthesised gels to separate enantiomeric solutes as a function of various physico-chemical parameters (degree of modification, crosslinkage...) will be studied.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Role of Notch signaling pathway in Glioma Stem Cells'.

assistant: **Innovation**

Glioblastoma multiforme (GBM) is the most common malignant intracranial tumor in adults. Despite the knowledge of the genetic alterations associated to GBM and the improvement in neurosurgery and chemo- and radiotherapy, little improvement has been achieved in the median survival. Recently, glioma stem cells (GSCs) have been identified to be responsible of the origin, recurrence and drug resistance in GBM, constituing so an attractive therapeutic target in the fight against gliomas. The present project aims to study the biology of GSCs and characterize their genomic and transcriptomic in response to inhibitors of the Notch pathway. This pathway has been demonstrated to be very important in glioma and alterations in components of this pathway have been identified in GBM. The research line proposed here will be multidisciplinary and in close contact with the patient. The objectives of the present project are:1. Isolation of GSC from clinical samples obtained after brain surgery through sorting for stem cell markers and characterization by SNP arrays, RT-PCR, CGH, etc.2. Analysis of the response to Notch inhibitors in GSCs ex vivo and in vivo. Analysis of the status of this pathway in GSC and the response to Notch inhibitors in culture (proliferation, apoptosis, neurosphere formation, differentiation, etc) and in vivo after injection of GSCs intracranially into mice. Gene expression analysis of tumors treated with Notch inhibitors in order to identify genes associated with response to treatment.3. Test of candidate genes involved in resistance to treatment in vitro and in vivo.  By blockade using RNA interference or inhibitors.4. Clinical correlation. Results obtained in the laboratory will be correlated with clinical data from patients involved in the Notch inhibitor clin