RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Regulation of gene expression in sebaceous glands', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In the pathogenesis of dermal inflammation, sebaceous glands (SGs) were considered as impotent players that are under the control of other cell types, but without any feedback on them. Only research of the past decade put SGs into our focus showing that besides their contribution to the lipid layer covering the skin surface and the hair, SGs are also capable of exerting inflammatory responses, thus providing an interesting cell type where lipid metabolism and inflammation is linked at a cellular level.The genetic programs responsible for the dual functions of lipid metabolism and inflammation in SGs can be regulated at various levels. Members of the DNA binding nuclear receptor superfamily such as vitamin D or the vitamin A receptors, the master regulators that sense the lipid environment and regulate different cellular functions via the regulation of their target genes, are expressed also in SGs although their cell specific effect on the gene expression was approached in only a limited extent. Recently, microRNAs, short non-coding RNAs that negatively regulate gene expression by binding to their specific target mRNA(s), representing another level of gene expression regulation, were also shown to be expressed in SGs, however, their function in SGs of skin diseases/skin inflammation is as yet unexplored.In the proposed study we aim to identify and link the genetic programs and their possible regulators in SGs that lead to their dual function of active lipid metabolism and inflammation. Furthermore, putting and comparing SGs in different disease specific contexts of inflammation such as acne and atopic dermatitis provides interesting models for dermatological research that may open many new avenues for understanding the role of SGs in disease progression and in the develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ModULar Tools for Integrating enhanced natural treatment SOlutions in URban water CyclEs' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The overall goal of MULTISOURCE is to, together with local, national, and international stakeholders, demonstrate a variety of about Enhanced Natural Treatment Solutions (ENTS) treating a wide range of urban waters and to develop innovative tools, methods, and business models that support citywide planning and long-term operations and maintenance of nature-based solutions for water treatment, storage, and reuse in urban areas worldwide. MULTISOURCE will allow users to identify multiple sources for local water reuse, promote increased uptake of nature-based solutions, and minimize discharge of water that has not received adequate treatment. MULTISOURCE will deliver new knowledge about ENTS and their ability to remove waterborne contaminants and provide effective risk reduction for chemical and biological hazards, as well as their capacity to be integrated into the landscape and contribute to the improvement of urban habitats. The project includes seven pilots treating a wide range of urban waters. Two individual municipalities (Girona, Spain; Oslo, Norway), two metropolitan municipalities (Lyon, France; Milan, Italy), and international partners in Brazil, Vietnam, and the USA will contribute to each of the main project activities: ENTS pilots, risk assessment, business models, technology selection, and the MULTISOURCE Planning Platform. The use of urban archetypes in the Planning Platform will enable users to quickly classify regions (in both developed or developing countries) suitable for the application of nature-based solutions for water treatment (NBSWT) and compare scenarios both with and without NBSWT. This unique approach provides the knowledge, business models, and modular tools that will enable stakeholders to conduct fit-to-purpose, large-scale planning in thei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of a flexible and energy-efficient pressurised microwave heating process to produce 3D-shaped renewable bio-polymer foams for a novel generation of transportation packaging' under Seventh Framework.

assistant: **Concept**

Expanded Polystyrene (EPS), Polyurethane (EPU), Polyethylene (EPE) and Polypropylene (EPP) represent the most popular moulded cushion packaging materials applied for transport packaging applications. However, despite of their functionality, the widespread use of these polymer foams of synthetic origin implies considerable environmental concerns. The depletion of non-renewable fossil raw material resources associated with emissions of greenhouse gases, such as C5H12 and CO2 applied as blowing agents during processing, are the most direct impacts on the environment. Moreover, their non-biodegradable  / non-compostable nature associated with the short life of cushion packaging products rises up fundamental concerns regarding waste disposal. Recycling, which is the solely applicable solution for preventing those synthetic foams entering the waste stream, appears in fact to be rarely applied due to cost-ineffectiveness and lack of effective recycling system.   With this in mind, bio-based plastics represent an emerging highly promising solution for protective transport  packaging provided that they can be processed in foamed products resulting in adequate functional requirements.   Within this framework, the project idea is to develop a flexible, energy-efficient and environmentally-sustainable manufacturing process enabling the production of biodegradable foamed 3D-shaped packaging originating from renewable raw materials (i.e. starch and water). Within the proposed process, expansion and foaming of the bio-polymer will be driven by pressurized microwave technology, exploiting the inner water content of the material itself to generate vapour.   The proposal is fully compliant with the targeted topic “NMP-2007-2.4-1 Flexible efficient processing for polymers”, as the propose
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Universal GPCR Activity Sensor for Next Generation Drug Discovery' in the context of a Horizon Europe call.

assistant: **Objectives**

This project by a consortium of academic labs and small biotech companies concerns a new key innovation for the development of drugs targeting G protein-coupled receptors (GPCRs). GPCRs are the most important class of therapeutic targets, both for current drugs and those under development, covering about a third of the €1.2 trillion pharmaceutical market. Recent research has revealed that GPCRs do not function as simple on/off switches but instead can adopt multiple conformations leading to complex textures of downstream effects. Functionally selective drugs modulate the GPCR structure to stimulate certain downstream pathways over others. In the search for this next generation of better drugs, the pharmaceutical industry currently employs multiple (10+) distinct GPCR assays, performed in non-identical cellular contexts, and misleading readouts from this approach contribute significantly to costly drug failure. Here we propose a radically new single-assay technology platform that will enable detection and functional classification of drug candidates with superior confidence compared to today's approaches. Its unique design supports streamlined drug discovery from the test tube to the native disease-relevant cell, as well as the capacity to efficiently harness artificial intelligence (AI) in the design of better drugs. The technology is based upon highly informative fluorescent sensor reagents that react to different receptor conformations with subtle, flexible changes in their structure. In this Pathfinder project, our main objective is to demonstrate that the conformational fingerprints generated by these sensors correlate to specific cellular signalling profiles, i.e. GPCR activity states (proof of principle). We believe that the UniSens platform will become the standa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'How will life be in 2020?'.

assistant: **Concept**

This proposal aims to raise awareness of the prominent role researchers and how their work plays in our currently every day and for the future. Bearing in mind Horizon 2020 Societal Challenges, the ERN2013 will promote and disseminate what in terms of science and innovation is being done in Portugal.The extensive and nationwide range of activities already planned and being prepared have one major aim: to show that researchers are ordinary people with extraordinary jobs! This will be done through direct engagement of both the general public and researchers in science awareness, across 26 main cities and villages in several venues.Coordinated by Ciência Viva (Lisbon), there is a regional coordinator in each NUTS II region in Portugal. The role of each regional coordinator is to mobilize the research community, local companies and associations, as well as regional/local press, using the same coordination rational from 2012.This is an inclusive proposal welcoming all interest research-related entities. The key message agreed between partners and all associated/participating entities is that we should take up this opportunity to bring research close to the people and not only expect that people come to a specific venue. Outdoor activities will be organized in partnership with municipalities/regional authorities as an added value of their service and a way to show the richness existing in each territory. In parallel, a very diverse range of edutainment indoor activities is planned and more are on the making.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MidInfraRed PHotonics devices fABrication for chemical sensing and spectroscopic applications' (MIRPHAB).

assistant: **Innovation**

The MIRPHAB (Mid InfraRed PHotonics devices fABrication for chemical sensing and spectroscopic applications) consortium will establish a pilot line to serve the growing needs of European industry in the field of analytical micro-sensors. Its main objectives are to:• provide a reliable supply of mid-infrared (MIR) photonic components for companies incl. in particular SMEs already active in analytical MIR sensing• reduce investment cost to access innovative MIR solutions for companies already active in the field of analytical sensors, but new to MIR photonics based sensing • attract companies new to the field of analytical sensors, aiming to integrate µ-sensors into their products.To fulfil those objectives, MIRPHAB is organized as a distributed pilot line formed by leading European industrial suppliers of MIR photonic components, complemented by first class European R&D institutes with processing facilities capable of carrying out pilot line production. MIRPHAB provides:• access to MIR photonic devices via mounted/packaged devices for laser-based analytical MIR sensors• expert design for sensor components to be fabricated in the pilot line plus training services to its customers.The platform will be organized such that new developments in MIR micro- and integrated optic components and modules can be taken up and incorporated into the MIRPHAB portfolio. MIRPHAB will work on a convincing scheme for the flow of hardware and information, suitable to operate a distributed pilot line efficiently. MIRPHAB will develop sound business cases and a compelling business plan. Potential cost-performance breakthroughs will be shown for reliable MIR sensing products based on building blocks provided by MIRPHAB. MIRPHAB will become a sustainable source of key components for new and highl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Consensus workshops : consumers, scientists and stakeholders from the whole food chain co-operate to identify and define consensus on key food issues, linking these with eu food policy and the european research agenda.'.

assistant: **Objectives**

Consumer confidence in the food supply has been undermined. This proposal will set up THREE CONSENSUS WORKSHOPS with consumer representatives, key EU research scientists and stakeholders from the whole food chain to address issues from the consumer agenda. The objectives are to facilitate interactive dialogue, to understand different perspectives, problems and opportunities; to inform discussion and debate; to communicate, network and identify consensus for the future. Better focus for new technology and policy developments will result from this innovative approach to the lack of understanding and dialogue between consumers, scientists and stakeholders about food safety, quality, new technologies , regulatory developments , nutrition questions and food emergencies. Briefing papers, proceedings, information and policy positions will be published and web pages used to disseminate the findings extensively.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Chromogenic peptide substrate tests for determining thrombotic risk factors in blood' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Thrombotic disorders are the major causes of mortality and morbidity in Europe. Diagnostic assays, including chromogenic peptide substrate assays (CS) for thrombosis and related diseases, have led to a multi million Euro market for kits for the measurement of these factors. Despite the knowledge that blood cells play a major role in thrombosis, all of the CS assays are performed using plasma. It is very probable that a large majority of the thrombotic risk factors not identified in plasma (60%) are associated with cellular elements of blood. The aim of the project is to develop novel CS assays to measure thrombotic risk factors in whole blood. The project will lead to the production of diagnostic kits for routine hospital laboratory assays as well as bed-side" or even "home-use single tute or "Clinistick"-type tests. The commercial possibilities for these assays are enormous, and it is probable that the project will lead to major break through in thrombosis diagnosis."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cognitive-level annotation using latent statistical structure' in the context of a Sixth Framework call.

assistant: **Objectives**

CLASS is a basic research project focused on developing a specific cognitive ability for use in intelligent content analysis: the automatic discovery of content categories and attributes from unstructured content streams. More specifically, it will study object recognition and scene analysis in images, video, and accompanying text streams. Current visual recognition methods either work at unsatisfyingly low semantic levels, or require large amounts of manually labelled data for training. Autonomous learning will make them more adaptive and allow more general classes and much larger and more varied data sets to be handled. This will be useful in many applications of cognitive systems and intelligent agents that handle streams of sensed data.We will study both fully autonomous and semi-supervised methods at three levels of abstraction: new individuals (specific people, objects, scenes, actions); new object classes and attributes; and hierarchical categories and relations between entities. The work will combine robust computer vision based image descriptors, machine learning based latent structure models, and advanced textual summarization techniques. The potential applications of the basic research results will be illustrated by three proof-of-concept demonstrators: an Image Interrogator that interactively answers simple user-defined queries about image content; a Video Commentator that automatically creates textual descriptions of the action and content of situation comedy videos for visually impaired users; and a News Digester that combines television news stories with captions from several sources to create a textual and visual digest of them.The CLASS consortium is interdisciplinary, combining five leading European research teams in visual recognition, text understand
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Bacterial Eavesdropping for Fast Antibiotic Susceptibility Testing' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Antimicrobial resistance (AMR) is a global health problem, endangering milliAntimicrobial resistance (AMR) is a global health problem, endangering millions of lives. Rapid Antimicrobial Susceptibility Testing (AST) plays a crucial role in determining the type and concentration of antibiotics required to inhibit the growth of a pathogen. However, the major issue  with  the  current  ASTs  is  the  slow  diagnostics,  from  24h  to  a  few  days,  leading  to  mis-prescriptions and/or over-prescriptions, thus severely impacting treatment outcomes. At SoundCell, we developed SoundCell technology, a breakthrough technique that reduces the AST time from a few days to less than 1 hour. It is a graphene-based biosensor technology that uses nanomechanical vibrations of ultrathin micron-sized graphene drums to detect the motion of a single bacterium. We demonstrated that motion of alive and dead bacteria are different when adhered to the graphene sensors and we can correlate such changes to antibiotic susceptibility. During the EICT, we will mature SoundCell technology into a high-throughput cost-effective AST. We will develop high-volume manufacturing methods and engineer a user-friendly low-cost prototype readout system. We will validate our AST prototype in 2 clinical labs through testing of a variety of pathogenic clinical isolates and benchmarking speed and sensitivity of our platform against other AST techniques. We will establish our exploitation strategy and regulatory roadmap, develop, and execute the business model, and develop stakeholders engagement. SoundCell technology will directly lower healthcare expenses by shortening hospital  stays  with  fewer  lab  and  diagnostics  tests  and  improve  clinical  outcomes  of  patients  by reducing recovery time, secondary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Diffeomorphism Invariant Gauge Theories, Asymptotic Safety and Geometry', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The aim of the proposed research is to develop a new description of gravity in four spacetime dimensions. This will (i) serve as a new tool to investigate the conjecture that four-dimensional quantum gravity may be ultra-violet complete (asymptotically safe); (ii) provide new techniques for the problem of classification of geometric structures on four-manifolds. To this end we shall study a certain large class of diffeomorphism invariant SU(2) gauge theories. The low-energy physics of these theories is known to be indistinguishable from that of general relativity (GR). At high energies, they provide an interesting type of deformations of GR, with the key property that the number of propagating degrees of freedom is the same as in general relativity. To test the asymptotic safety conjecture we shall perform perturbative one-loop computations to determine how these theories are renormalized by quantum corrections and then study the resulting renormalization group flow. The same class of theories will also be used to solve some of fundamental conjectures about the geometric structures on four-manifolds. The most optimistic scenario results will prove the asymptotic safety in four-dimensional quantum gravity and explicitly describe the physics occurring around the ultra-violet fixed point. The impact of this on theoretical physics will be comparable to the impact of the 1973 discovery of asymptotic freedom on the high energy physics. The work on the proposal will involve some of the world leading scientists as collaborators and advisors. The project will be carried out in the School of Mathematical Sciences at the University of Nottingham, one of the major mathematics research centres in the UK. Regular long-term research visits to our group by leading scientists, as well a