RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Small4Good: Sustainable multifunctional management by small forest owners in support of bioeconomy, biodiversity and climate' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The strategic objective of Small4Good is to enable and activate small-forest owners to safeguard biodiversity and enhance the provision of ecosystem services from Europe's forests through multifunctional and locally adapted management models that are financially supported by PES and implemented with support by of digital- and AI-based solutions. Snall4Good will develop multifunctional management and business models for owners of small forest financially enabled by schemes for PES with focus on biodiversity and carbon farming. The management models are supported by digital and AI solutions to improve the capacity and engagement of small-forests owners. To ensure the long-term impact the models must be aligned with the motivations of the individual owners and the local ecosystem and socioeconomic conditions. Hence, Small4Good focuses on understanding the motivations of small-forest owners and pursues the development of business and management models through a multi-actor living lab approach in four regions across Europe. This follows a co-creation approach that promotes rapid acceptability, prototyping, and implementation to outline realistic locally adapted pathways towards multifunctionality that are aligned with the ambitions outlined in the EU Forest Strategy. The lessons learned will be used to enable small-forest owners across Europe to enter the pathway towards sustainable and multifunctional management as a basis for a fair and inclusive transition towards the bioeconomy. Small4Good is aligned with the work programme by providing outcomes contributing to the policy goals of the European Green Deal including increasing the multifunctional role and resilience needs under climate change and contribution to halting and reversing biodiversity loss. This is achieved thr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Structural and functional analysis of nup84, a novel nuclear pore complex protein associated with can/nup214' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The interphase nuclear envelope is a selective barrier which defines the boundary between the nucleus and cytoplasm and as such governs the transport of macromolecules between these two compartments. In this regard the nuclear envelope plays a central role in determining nuclear activity during cell growth and development. The channels which mediate this regulated traffic of molecules across the nuclear envelope are the nuclear pore complexes (NPCs). These are not simple pores embedded in the nuclear envelope but large and elaborated supra molecular assemblies. At present the nature of the molecular machinery within the pore complex and interactions with other nuclear and cytoplasmic components remain largely obscure. We have characterized a group of nuclear complex proteins and begin to map their functional and physical interactions. It is the goal of this proposal to study in greater detail a novel component of the NPC that we have identified and cloned. This will provide new information on the organization and function of the NPC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Single cell analysis of tumor cells for personalized cancer vaccines'.

assistant: **Concept**

Personalized cancer vaccines are therapeutic vaccines custom tailored to target tumor-specific mutations unique to a given patient. Such a treatment offers great hope for cancer patients as it does not harm healthy cells and has the potential to provide life-long remission. The emerging view of cancer as a dynamic evolutionary process that produces startling genetic heterogeneity and escapes treatment poses challenges for cancer vaccines. Yet progress in elucidating the nature of tumor heterogeneity has been impeded by experimental challenges, and the impact on vaccine design has not been investigated. The comprehensive research agenda outlined in this proposal aims to investigate tumor heterogeneity at the single cell level using novel experimental and theoretical methods with the end goal of maximizing the efficacy of personalized cancer vaccines. To accomplish these goals, I will first develop cost-effective high-throughput methods to measure the “mutanome” of hundreds of single cancer cells, integrating next-generation sequencing with microfluidics. Next, novel lineage treeing algorithms will be developed to reconstruct the evolutionary history of the cancer. I will then systematically apply this method to murine and human tumors and thus shed new light on cancer heterogeneity and evolution, reveal driver mutations with unprecedented resolution, enable the design of highly potent cancer vaccines and pave the way for new diagnostic tools. This proposal fits well within the scope of research conducted by the host institute, which aims to develop fundamentally new individualized cancer immunotherapies, with the first personalized cancer vaccines entering clinical trials in the near future. The host institute therefore has the experience and the resources to support thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cloud archive user service', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The fundamental aim of the Cloud Archive User Service (CLAUS) project is to provide dimate modellers with easy access to an archive of satellite based doud data. This aim can be sub-divided into three separate, measurabie objectives: Objective 1Data set provision It is proposed to prepare an archive of integrated satellite images based upon data from the Intemationai Satellite Cloud Climatology Project (ISCCP) and covering the period 1983 - present. In response to customer requirements these data will be produced on a reguiar 0.5ø grid at 3-hourly intervals. The data processing method wili be based on a technically proven method developed using single year of data. Objective 2Data Access The data, and descriptions of the integration methods employed, would be made freely available over the network using the CEO European Wide Service Exchange (EWSE). Objective 3 Operational Testing The archived data will be tested by the participating dimate research groups in an operational environment over an extended period. Folbwing an inffial testing phase, modffications may be made in consultation with the users. The customers for CLAUS are global climate modeilers and climate researchers who need to compare observed data (as provided by CLAUS) with their own model outputs. Such comparisons would allow the models to be improved and be of enormous benefit to the dimate modelling community. The developrnent of General Circulation Models (GCMs) able to reproduce climate variables on various spatial and temporal scales, coupled with increases in computing power, has ied to greatly increased understanding of the world's climate. However, there are very real difficulties in validating the models; the Intergovemmental Panel on Climate Change (IPCC) has identified the provision ot observat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'PErPetuating Stemness: From single-cell analysis to mechanistic spatio-temporal models of neural stem cell dynamics' (PEPS).

assistant: **Concept**

Neural stem cell (NSC) populations in the vertebrate brain generate adult-born neurons for plasticity, growth, and repair. Neurogenic and gliogenic capacity, based on long-term NSC maintenance, functionally define “stemness”. Stemness embodies massive NSC heterogeneity at the single cell level and requires control of maintenance or differentiation decisions at the population level. These features remain mechanistically unreconciled. We hypothesise that spatiotemporal interactions among heterogeneous NSCs are coordinated to control the population behaviour. Thus, we propose a multi-dimensional project exploring these features in time and space, to decode the mechanistic principles of stemness. To this end, we bring together experimental and theoretical groups with complementary expertise in NSC biology, biostatistics and mathematical modelling. In an iterative experimental-mathematical approach, we will (1) solve the topology of individual NSC trajectories in transcriptomic space, (2) identify local cell-cell coordination mechanisms that impact these trajectories in situ, and (3) decode the resulting systemic properties and outputs of NSC ensembles at long-term and large spatial scales. This programme will result in original methods, including retrospective transcriptomics in single cells, innovative barcode transfers, and a novel mathematical framework to describe structured spatio-temporal population dynamics. We will focus on two biological model systems, the adult mouse ventricular sub-ventricular zone and zebrafish pallium, where NSC ensembles display comparable heterogeneity but differ in spatial organisation and fate dynamics. Together, PEPS will uncover the general principles and regulatory mechanisms of perpetuating stemness in time and space. It will lay the co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'On some open problems about curves in Algebraic geometry' (XTATADUCROHET).

assistant: **Innovation**

After four years of full-time research during my PhD Thesis, a partnership with the French Ecole Polytechnique and the Indian Tata institute of Fundamental Research represents the best opportunity to widen my mathematical expertise as well as to establish a strong relationship with the top ranked researchers (especially in my field of interest) in a country that is called to play a major role in the beginning century.On the one hand, my Thesis work raised several questions of interest. One the other hand, this excellence partnership will help me to understand deeply the background of some important open problems I am interested in order to be able to contribute to their resolution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Development of new therapeutic substances and strategies for treatment of pain in patients with advanced stages of cancer'.

assistant: **Concept**

Prolonging the life expectations of patients with progressive cancer could be done by modern medicine. However progressive pain that is associated with progression of disease is the major factor that destructs last moment of life. Severe and progressive and uncontrolled pain is a major reason of requesting euthanasia. The applications of oral (morphine) pills or transdermal patches with lipophylic analgesic drugs are the most common treatments of cancer pain. These compounds penetrating into central nervous system produce side effects (respiratory depression, constipation, tolerance, sedation, etc) to such extend that pain treatment is reduced by the doctor or refused by the patients. The discoveries of the last years indicated the changes in expressions of pro- and antynociceptive receptors in pathologically changed peripheral tissues as well as in central nervous system. The modulation of these receptors with composition of receptor ligands may block nociceptive signal formation and transmission more effectively than traditional monotherapies. The objectives of this project is to focus on development of new multitarget compounds and the method which will interact in large proportion with opioid receptors expressed in inflamed and/or pathologically modified tissues. Partial penetration into central nervous system will results in synergic pain suppression interaction between peripheral and central nervous system. Alternatively, developed compounds could be applied directly into central nervous system to interact with specific, pathological composition of receptors. Developed compounds will be screened in vitro in a cell silicon hybrid biosensor and selected compounds, in vivo in rodent's cancer pain models. Project wills results with new basic data on structural require
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Autonomous multimodal implantable endoscopic capsule for the gastrointestinal tract' (AUTOCAPSULE).

assistant: **Innovation**

AUTOCAPSULE aims at demonstrating the viability of a technology for early diagnosis of Inflammatory Bowel Disease (IBD) and bowel cancer and for monitoring of treatment effectiveness at primary or secondary point of care. The technology vision is based on an untethered autonomous capsule that is both implantable in the gastro-intestinal (GI) tract for several weeks in order to monitor a specific area, and that can explore the GI tract for endoscopy in a point of care, through magnetic manipulation with an external robotic arm and limited expertise of the operator . The capsule is capable of multimodal sensing, including micro ultrasound imaging, white light imaging, ph monitoring and inflammation monitoring.The GI system is highly complex, subject to frequent external stimulus through eating and digestion, and carries an extremely high burden of disease: 15 – 40% of the European population report functional GI conditions. However, the range of conditions encompassed is too diverse a target for immediate action and we will therefore focus on inflammatory bowel disease (IBD) and colorectal cancer. Even for those diseases alone, the affected European populations are large, with colorectal cancer being the most common cancer in men (30% of all new cancers) and second most common in women (25% of all new cancers) with a total of about 350,000 cases in the EU in 2012. Moreover, the burden on healthcare systems is rising worldwide, with increased screening cited as the primary reason.In the course of the AUTOCAPSULE project two parallel tracks will be followed to demonstrate the technology vision, each focusing on a subset of the vision capsule features. One focuses on the development and demonstration of an untethered autonomous robotic capsule, capable of micro ultrasound im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular photoacoustic imaging of stem-cell driven tissue regeneration' (MOPIT), addressing dissemination and exploitation.

assistant: **Impact**

I propose to develop a new generation of molecular photoacoustic imaging technologies and methods capable of detecting single deep tissue cells in preclinical studies of tissue regeneration. In order to achieve this goal, an interdisciplinary research programme involving physicists, engineers and life scientists is required to address the following objectives: 1) the development of novel photoacoustic imaging technology that provides high sensitivity and acquisition speed, 2) the development of the theoretical framework and experimental methods for quantitative imaging, 3) the development of novel genetically expressed reporters, and 4) the preclinical application in small animal models of tissue regeneration. This will result in a preclinical imaging modality has the potential to combine single cell sensitivity and microscale spatial resolution in deep (centimetre range) tissue regions with molecular, physiological, and anatomical imaging capabilities. The instrumentation and methodologies developed in this project will be applied to noninvasive, longitudinal, and quantitative studies of stem cell driven tissue regeneration, such as angiogenesis in bone fractures and muscle trauma. It will allow the detection and tracking of single stem cells and the probing of stem cell function. This will provide unprecedented opportunities for correlating cellular localization, migration, and function and with anatomical changes - knowledge that can be exploited to develop novel drugs and cell-based clinical therapies. Crucially, the technologies and methodologies developed in this project will be directly applicable to a wide range of other fields of the life sciences, such as cancer research and neurology.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Combinatorial synthesis of enzyme inhibitors as new generation anticancer agents' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

In recent years, the search for new lead molecules in pharmaceutical research has been radically altered by the introduction of combinatorial technologies. Our goal is to apply these techniques to the discovery of novel anticancer agents designed to act on a specific enzyme in the cell. This enzyme, termed Protein Farnesyl Transferase (PFTase), is implicated in the post-translational modification of proteins such as Ras, found mutated in approximately 30% of all human cancers. Compared to classical cytotoxic agents, PFTase inhibitors represent one of the few classes of anticancer agents that could constitute a real improvement in the cancer therapy. Indeed, these drugs are able to selectively target cancer cells while normal cells remain unaffected. Ras proteins required prenylation for activity and this transfer of a farnesyl group from farnesyl pyrophosphate (FPP) to a cysteine residue of Ras protein is catalyzed by PFTase. Two approaches are possible to inhibit this farnesylation. The first is to design compounds that mimic the terminal residue of the Ras protein (CAAX box) and the second is to design compounds that will compete with FPP. The efforts of our chemistry team have been mainly focused on the discovery of original PFTase inhibitors that mimic the CAAX box. The project of the Fellow will be to design compounds that will compete with FPP. This new approach will create a stimulating environment in that it will require numerous exchanges with other researchers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Computer Aided Multispectral Ulstrasound Diagnostic Device' (UltraEASY) under Horizon 2020.

assistant: **Objectives**

Every 40 seconds, someone in Europe suffers from a stroke killing 1,000 Europeans daily. The resulting economic damage is immense. In the 2006 wake-up-study funded by the EU the economic damage in Europe amounts to 36 billion EUR per year. The objective of this project is the clinical validation of SoNovum AG’s UltraEASY™ II Brain Vitals Monitoring System and the underlying CAMUD technology for diagnosing and monitoring neuropathologies in acute events and at-risk patient groups. CAMUD stands for “Computer Aided Multispectral Ultrasound Diagnostics” and is a novel diagnostic method based on molecular acoustics. It measures the feedback of ultrasound waves on multiple frequencies, which is interpretable for the first time thanks to modern computer technology. The technology enables, among other things, a fast, very precise and non-invasive diagnosis of the brain tissue in the beginning of the therapeutic time frame as well as further, continuous monitoring. Therewith physicians will be able to diagnose acute events more quickly and preventatively at-risk patient groups, even before harmful incidents occur. Initial target market groups for UltraEASY II include the stroke units in clinics as well as family and specialist's practices in Europe with regard to global markets as well. Because of high mobility, flexibility and the small acquisition costs, it is well suited as basic equipment for practices as well as, in its mobile version, for helicopters, rescue vehicles and ambulances of clinics and emergency organizations. The objectives of this Feasibility Study are the examination of the market acceptance towards UltraEASY II, addressing clinics and physicians as well as involving patients, patient organizations and health insurance carriers, in order to conduct the risk e