RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Imaging Single Glycoconjugates' under Horizon Europe.

assistant: **Concept**

GlycoX aims to develop single molecule analytical methods to address the challenge of elucidating glycoconjugate structures. Glycoconjugates are glycans (a.k.a carbohydrates) that are attached to another biomolecules such as proteins or lipids. Glycoconjugates are essential to all living organisms, carrying out key cell-cell communication roles in immune system or in microbial infection. Glycoconjugates are found in all biological systems and yet, when compared to proteins or nucleotides, very little is known about their structures and how they lead to their biochemical properties or how they can be exploited in therapeutics. Efforts to reveal their structures by ensemble averaged approaches, whether primary structures (sequences) or secondary structures (conformations), have been severely hampered by the high complexity and flexibility of glycans.GlycoX addresses this challenge by direct imaging of single glycoconjugate molecules, devoid of any ensemble averaging. To this end, glycoconjugate ions generated from electrospray ionization are soft landed on surface and imaged one-at-a-time by scanning probe microscopy in vacuo. The Project proposes the use of direct imaging (1) to identify the glycoforms of any glycoconjugates (i.e. variants of a specific glyconjugate that possess different glycan primary structures), (2) to sequence any glycan residues in any glycoconjugates, and (3) to determine the conformations of any glycoconjugates. The Project plans to focus on glycoconjugates that are intractable by present analytical methods, many of which are central in immune system, in microbial infection, and in emerging diagnostics, drugs, and vaccines. These works have far reaching impacts: shedding light into the language used by cells to communicate and by pathogens to inf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'IMERSO - Virtual Reality System' (IMERSO).

assistant: **Innovation**

This innovation project aims to introduce IMERSO: a revolutionary Virtual Reality (VR) system for the enterprise market. VR technology has been used for decades by large firms with well-documented economic benefits, but the required equipment remains too expensive and cumbersome for millions of SME’s and Public Actors. Our unique concept disrupts the established high-price VR market by democratising this technology to organisations of any size. IMERSO enables its customers to drastically reduce product development costs and increase sales through better customer engagement. This project will modernise the multimedia aspects of product design and prototyping, customer engagement, and workforce training. Likewise, it addresses Europe’s objectives of modernising education and training systems, along with boosting industrial competitiveness.The global VR Head-Mounted Display (HMD) market is estimated to grow rapidly to €11,7 billion by 2020, with a CAGR of 74% from 2015 - 2020. In Europe alone a potential customer base of 22 million SME’s can benefit from using IMERSO in their work processes. Initial customer contacts have increased the team’s confidence in the value-proposition of this innovative solution. This Phase-1 study will minimise technical and market acceptance risks by involving customers early in the system design phase and assure a user-driven development process. ODI’s support of this project enables filling a market gap that strengthens Europe’s position on this powerful emerging technology — a market sharply divided between established vendors catering to high-end customers and upcoming consumer VR Gaming devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Feasibility study of yarns and fabrics with annexed electronic functions' (ARIANNE).

assistant: **Innovation**

The project concerns a feasibility study of textile circuits made with an electronically functionalised yarn, aimed to the development of a textile yarn with electronic functions (a 'textile transistor') and to the study of the electronic behaviour of the fabric seen as a complex electronic network whose complexity and final behaviour is determined both by the electronic properties of the yarn and by its topology in the fabric. The project is divided into some fundamentals lines:1) Project and feasibility study of fibres and yarns endowed with electronic properties;2) Elaboration of a circuital model of the yarn which takes into account its electronic properties;3) Determination of the yarn topology in a fabric and simulation of the electronic properties of the fabric with the aim of defining its electronic transfer function.OBJECTIVESThe project aims to assess the feasibility of yarns endowed with electronic functions and, as a consequence, the properties of fabrics made-up with such yarns. The feasibility evaluation concerns several aspects: on one hand, those concerning materials and technologies employed to obtain such yarns; on the other hand, their electrical model which allows to consider yarns as elements of a 'textile circuit', the fabric. Finally, the electronic transfer function of fabrics with different yarn topologies will be evaluated. The research idea to assess has considerable potential spin-offs in a number of fields, such as biomedicine, telecommunication, rehabilitation, sport performance monitoring, virtual reality, where there is an increasing demand for portable, fully automated, easy-to-use, remote controllable, electronic systems. Electronic yarns will allow the development of a new generation of portable electronics, wearable electronic systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Design of an agricultural greenhouse for intensive growing of microalgae in fresh / sea water with a syngas production plant and organic farming of chickens and pigs outdoors.' under Horizon 2020.

assistant: **Concept**

According to many international studies, world population growth and climate change will end in a reduction of food, energy and pharmaceutical resources. One possible solution is an increase in the production of microalgae. The business opportunity consists in the construction of a production plant integrating algae cultivation in photobioreactors with a syngas CHP as a source of carbon, required for the photosynthetic process of microalgae. Market application deriving from algae include: biomass for combustion and organic matrix for anaerobic digestion plants; food supplements for human/animal use; pharmaceutical/cosmetics products; fertilizers; complete pilot line for cultivation. Other applications include licensing of concept, technology and brand and experimental photobioreactors for bio-lighting algae research. It is a growing market with a world potential estimated at +30% each year and a global size of 150M€ in 2016. Key reasons explaining its novelty are: reduced need of land; use in low-quality agricultural land; no emissions of greenhouse gases/pollutants; absence of aggressive waters; significant amount of carbon dioxide captured and stored; pure product with high Ω3 content. Potential customers include: food supplement producers and retailers; livestock and poultry producers; pharmaceutical and cosmetics industry; agricultural product retailers and farmers; bio-fuel refineries; agricultural and processing companies interested in market replication or in becoming licensees; research institutions; general public, families and young people. The structure of the work plan starts with the management (WP1), includes one WP devoted to a pilot line for microalgae production, including PBRs for research on bio-lighting algae (WP2) and continues with a WP dealing wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Unraveling the regulatory network of developmental programmed cell death in plants' (PROCELLDEATH) under Horizon 2020.

assistant: **Objectives**

Programmed cell death (PCD) is a fundamental biological process that actively terminates a cell’s vital functions by a well-ordered sequence of events. In both animals and plants, various types of PCD are crucial for development, health, and the responses to various stresses. Despite their importance, only little is known about PCD processes and their molecular control in plants. Still, an intricate regulatory network must exist that renders specific plant cell types competent to initiate and execute PCD at precisely determined developmental stages. I recently established a powerful developmental PCD model system in Arabidopsis thaliana, based on a PCD process occurring during root cap development. This root cap model has the potential to revolutionize existing concepts of plant PCD, as it combines a precisely predictable PCD process in easily accessible cells on the root periphery with the abundance of resources available for Arabidopsis research. Exploiting the root cap system will enable me to tackle unresolved fundamental questions about the regulation of developmental PCD in plants: How do cells acquire PCD competency during differentiation? Which signals trigger PCD execution at just the right moment? What are the actual mechanisms that disrupt the vital functions of a plant cell? I will obtain answers to these questions through a comprehensive strategy combining complementary approaches, taking advantage of cell-type specific transcriptomics, forward and reverse genetics, advanced live-cell imaging, biochemistry, and computational modeling. Our unpublished data point to the existence of a common core mechanism controlling PCD not only in the root cap, but also in other vital organs including the vasculature, anthers, or developing seeds. Thus, this project will n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a standard method (protocol) for the measurement of organic contaminants tars" in biomass producer gases"' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Measurement methods and definitions for organic contaminants in biomass gasification based CHP (combined heat and power) systems are numerous and non-uniform. As result, comparison of data and definition of clear maximum ollawable concentrations for these contaminants is problematic. This forms an obstacle for market introduction of the CHP systems as the contaminants can cause damage or an unaccemptable level of maintenance. The objective of the project is to remove this obstacle by developing a standard measurement method (Protocol) which is accepted and used by parties working on biomass gasification and has entered the standardisation procedure at CEN. This work continues an initiative started by IEA, EU and US-DoE to develop such a Protocol and will be based on the two draft Protocols which resulted from this initiative . The new Protocol will be optimised and tested thought R&D activities co-ordinated from the project. As acceptance and use by others is considered to be very important, dissemination and internalisation forms an essential part of this project. It will be accomplished by the use of internet, Conference contributions, involvement of Relievers and a Workshop.The actual outcome consists of:- Two first versions of the Guideline issued for internal discussion and reviewing by a group of experts in 2000 and 2001 respectively. - The draft final and final version of the Guideline issued in 2002, before and after the Workshop held at the 12th European Biomass Conference in Amsterdam. - An inventory of R&D requirements for optimisation & evaluation of the Guideline prepared at the start of the project. With this document, new R&D activities were started in the course of 2000 to optimise the Guideline. The results of this R&D, including recommendations for fur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Structure Development During Solidification in the Processing of Crystalline Polymers' in the context of a Fourth Framework call.

assistant: **Objectives**

Objectives and content This research proposal is based on the general experience that processing of crystallizable thermoplastic polymers is still a highly empirical matter. This holds notwithstanding the fact that, nowadays, the major amount of polymeric materials, as processed world-wide, is of this type. This statement may be surprising in an area of computer simulation and automation. Curiously enough, the reason for this omission must be sought in an already well-recognized problem, viz. the lack of overlapping knowledge and experience of scientists and engineers. But, with such statements alone no problems can be solved. The present group consists of people who have been discussing this matter at length. So, a combined effort is proposed of specialists in polymer science, crystallization kinetics, heat transfer, flow and practical processing. By the interaction of these disciplines new effects are unearthed as flow induced enhanced crystallization, producing special morphologies, or temperature gradient dependent kinetics, also reflected in the product morphology. Model experiments are proposed which, as a general goal, have to deliver the necessary data for modelling and computer simulation. The influences of additives, as nucleation agents etc., will not be overlooked. Last and not least the consequences of any purposely created structure (morphology) on the product quality (dimensional stability, outward appearance, ageing, mechanical test results) will be investigated in the hope to arrive at more than qualitative guidelines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Genome sequencing of the pathogenic bifidobacterial strain Bifidobacterium dentium: insights from genetics and comparative genomics', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Bifidobacteria represent one of the most common inhabitants of the mammalian and animal gastrointestinal tract (GIT). In the human GIT their presence has been associated with beneficial health effects, such as prevention of diarrhoea, amelioration of lacto se intolerance, and immunomodulation. These correlations have led to the widespread use of many bifidobacterial strains as components of health-promoting foods (probiotic foods). Despite the generally accepted importance of bifidobacteria as probiotic components of human GIT microflora, and their use in health-promoting foods, there is a large paucity of information about their physiology, phylogenetic relationship, and underlying genetics. Bacterial genome sequencing is considered to be the gateway to a new era of biological investigation, which will shed light on the interactive genetics underlying all microbial properties.Unfortunately, so far bifidobacterial genomics represent an under-explored field since from a total of over 32 currently recognized species of this genus only one strain harbouring the Bifidobacterium longum species has been fully sequenced. Bifidobacteria represent an ideal target for studying the genetic borderline between health-promoting bacteria (probiotic) and pathogenic bacteria since bifidobacteria include both species with food-grade and probiotic properties as well as species exhibiting typical pathogenic characteristics. This latter group of bifidobacterial strains consists of Bifidobacterium dentium strains, which have been show n to be one of the main actor for human dental caries formation.This proposal will focus on the genome sequencing of a cariogenic B. dentium strain in order to shed light on the virulent determinants of this microrganism and to identify the genetic basis o f th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Empirical Knowledge and Antiquarian Architecture in Sixteenth-century Venice' in the context of a Horizon 2020 call.

assistant: **Objectives**

Cesare Pastorino will carry out this two-year Marie Curie Global Fellowship at Princeton University (USA) and the University of Venice Ca’ Foscari (Italy), with the supervision of Anthony Grafton (Princeton) and Marco Sgarbi (Venice). The overarching aim of the ANTIQUITATES project is to investigate the quantitative empirical practices of the early modern historical disciplines. Pastorino will analyze the case of antiquarian architecture in the Republic of Venice during the sixteenth century. He will consider a group of groundbreaking architects from Veneto, including Andrea Palladio (1508-1580) and Vincenzo Scamozzi (1548-1616), and their patronage networks. The activities of these architects moved seamlessly from texts to objects and back, merging the study of classical authors with archeological reconstructions, surveying, and practical mathematics. In their antiquarian analyses, these figures blended historical and quantitative empirical knowledge. Historiography usually associates quantitative empirical methods with the early modern growth of the natural sciences. Analyzing the patronage networks of antiquarian architecture in the Republic of Venice during the sixteenth century, this project will open a very different and innovative perspective: it will show how the humanistic and antiquarian study of the past included established practices of measurement and quantification. In sum, Cesare Pastorino will lay the foundations for a new and cutting-edge area of historical research on the role of quantification, measurement, and testing in the historical studies of antiquity in early modern Europe. This new research and the skills acquired during the fellowship period will impact his career very significantly. They will expand his current area of expertise, create new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dopaminergic neurons and the reward system in fish: a functional neuroanatomical multidisciplinary study' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The current proposal aims at elucidating the role of the dopaminergic (DA) system in regulation and control of reward systems. The study of DA regulation is of great importance since it has been known to regulate reward, as well as other vital neurological functions and several neuropsychological illnesses, but the underlying molecular mechanisms are still not fully understood. With the emerging technologies of in vivo imaging, optogenetics and transgenic techniques, it is today possible to better study the molecular mechanisms underlying reward behaviour. To this end, the zebrafish (Danio rerio) is an excellent model system where these tools are amenable for complex network analyses. It is believed that, as in mammals, DA neurons provide a central role in signal and response to salient stimuli. Therefore in this project we plan to 1. Establish which forebrain DA neuronal populations, brain targets and signalling molecules are active during reward conditions and2. Establish a causal relationship between these areas and the control of reward-motivated behaviour in fish. We will conduct this research by pinpointing DA neuron populations active during reward situations and their target areas by in vivo calcium imaging analysis and corroborating established focus brain networks by quantifying c-Fos and brain-derived neurotrophic factor (BDNF) expression by means of in situ hybridization (WP1). Thereafter, we will elucidate target molecules that are important during reward processing in established networks, by laser microdissection and a targeted and non-targeted approach, i.e. qPCR and RNA sequencing, respectively (WP2). Finally we will demonstrate causality between focus brain networks and reward oriented behaviour by optical and genetical regulation, i.e. optogenetics, o