RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'On line continuous aroma extraction from agrofood processing wastes', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The main objective of this project is to develop a new technology on resins which will enable extraction and selective recovery of aromatic compounds from food processing wastes. Indeed, nowadays, food industry does not have technologies efficient enough to avoid aromatic losses and to recover the whole aromatic compounds of the product. It results in many losses and biochemical changes which affect the quality of the extracted flavour. The main objectives of the project are: * The development of a continuous process to recover flavours from agro-food processing wastes on-line. This is an important innovation as actual processes are batch one. This is a necessary goal in order to achieve the economical viability for the system.* Improvements for the agro-food industry: amelioration of the taste by using natural reinforcements at low cost.* Taking into account the increasing demand of high quality natural products from consumers. Consumers are now more aware of green issues and are rejecting artificial substances in favour of natural alternative. There is a growing trend in favour of aromatic extracts for a number of large scale uses, including flavouring, fragrances, agricultural, pharmaceutical or medicinal preparations.* Conversion of environmentally-unfriendly wastes into food or non food ingredients. There is considerable industrial and political pressure to convert wastes into useful products. This project will bring together European partners to develop means for exploiting wastes for the extraction of high quality and commercially valuable products. SMEs will be very interested in the results of the project because they will find a new way to valorise their wastes with a high added value. Indeed, the flavour consuming branches of activity are a very interesting t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A drug strategy targeting heat shock protein 90 to combat metastatic, p53 mutant ovarian cancer.' (GANNET53), addressing dissemination and exploitation.

assistant: **Impact**

Epithelial ovarian cancer (EOC) is the most lethal gyncaecological malignancy causing 41900 deaths annually in Europe. The predominance of aggressive Type II tumours (comprised of high-grade serous, high-grade endometrioid, and undifferentiated carcinomas) and primary or acquired resistance to platinum-based chemotherapy profoundly contribute to the high mortality rate. The preeminant molecular hallmark of Type II tumours is the near ubiquitous presence of p53 mutations (in >96% of patients). There is a pressing need for more effective, innovative treatment strategies to particularly improve survival in Type II EOC patients. The two clinical trials GANNET53  and EUDARIO aim to achieve this goal by applying a highly innovative concept that has grown from solid basic research findings made by members of the GANNET53 consortium. This is a drug strategy inhibiting the central chaperone Hsp90 (heat shock protein 90) in p53 mutant (mutp53) EOC. In the GANNET53 trial this innovative Hsp90 inhibiton mechanism is used to target the central driver of aggressiveness and metastatic ability of these EOC cancers - namely stabilised mutant p53 protein - for degradation. In the EUDARIO trial the concept of Hsp90 inhibition is exploited to crucially inhibit DNA repair by rapid decay of key components of the Fanconi anemia pathway as well as of cell cycle checkpoint mediators following DNA damage by platinum-based chemotherapy. The clinically most advanced, second-generation Hsp90 inhibitor currently available (used in >600 patients in unrelated clinical studies) is used, Ganetespib, in a stratified approach in EOC patients with mutp53 Type II EOC. The first part (Phase I) of the GANNET53 trial will test the safety of Ganetespib in a new combination with standard chemotherapy (Paclitaxel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Spatial Competition between Railway Stations' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Policy makers and railway operators share a similar goal, increasing the use of rail, whether to meet policy goals (e.g. improved accessibility) or to improve the railways' financial viability. The key factor in rail use is the number and location of railway stations and their catchment area. Opening new stations, to reduce access/egress distance to/from the station, can be a way to increase rail use, but it is costly and can result in travel time penalties for passengers using the line but not the (new) station. Due to the value of transport services they provide (node value) and the value of other services (e.g. retail - place value), railway stations have an economic impact on their surroundings. This is (partly) manifested in the prices of real-estates around stations. This impact can play an important role in the financial viability of the railways, and in itself can justify changes in the number and location of railway stations in a given network. Spatial competition between stations would normally exist in large cities where demand for rail is served through several railway stations. Such competition can be counter productive in terms of increasing rail use and improving the railways' financial viability. In the above context the research main question is: Do overlaps in railway stations’ catchment and impact areas represent a burden on railways' financial viability while not contributing to the use of rail as a mode of transport? To answer the above question, the following objectives are set, which also illustrate the methodology adopted. • Measuring railway stations’ catchment areas and assessing the factors influencing it • Measuring railway stations’ impact areas and assessing the factors influencing it • Mapping the railway stations’ catchment and impact are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Unique Biomaterial-Drug Solution for Multifunctional Central Venous Catheters'.

assistant: **Objectives**

Central venous catheters (CVCs) play a critical role in healthcare and few medical devices are more important and widespread in modern medicine. Catheter-related bloodstream infection (CRBSI) is the most common life-threatening complication of CVCs. Reducing the risk of CRBSI among patients would save costs, reduce length of stay and improve mortality and morbidity. The major challenge of UNICAT is thus to develop a new CVC solution to prevent infection and thrombosis. The project partners will introduce a whole new way of thinking by introducing a disruptive approach which is more than just a coating of devices. A new material will, for the first time, combine ultra-biocompatibility with chemical resistance and desired mechanical properties, to effectively prevent adverse host response, inflammation and infection. A major problem in biomaterials science is that bioresistant materials are inevitably also chemically inert and hence highly difficult to manipulate by traditional wet chemistry. If manipulation (e.g. coating) is achieved, the solution is often unstable and fragile. UNICAT will address this problem by combining two materials using a novel method based on super critical CO2-chemistry. It will result in a hybrid material which is stably formed and combines the best properties of two or more materials.The success criterion is to exceed performance of coatings by producing the first fully biocompatible material to be used as sole robust bulk material of vascular access lines.UNICAT is an international and inter-sector collaborative project comprising R&D activities and secondments between the SME BioModics (BM), the University of Minho (UMinho), the Bar-Ilan University (BIU) and the Simula Research Laboratory (Simula). The consortium has identified the RISE progr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Functional Organization of Immunity by Lymphoid Stromal Cells' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The immune system is faced with a substantial challenge – it must provide rapid, tailored immunity to the host without a priori knowledge of when, where and which pathogen will invade, and at the same avoid damage to self. Recent evidence, including my own prior work, suggests that the anatomical organization of the lymphoid organ in which the immune response is initiated determines the quality and quantity of the response. Lymph nodes (LNs) are supported by a scaffold of mesenchyme-derived stromal cells (SCs) that not only provides gross anatomical support, but also produces critical survival factors and localization/movement guidance cues to antigen-presenting cells and antigen-responsive lymphocytes during the initiation of the immune response. Despite the now emerging role of SCs in immune responsiveness, it is unclear at a molecular and cellular level how these cells support the fine-grained spatial and temporal requirements for robust immunity. Here, using novel single cell datasets, advanced highly-multiplex immunofluorescence imaging, spatial statistics, genetic targeting and in house-developed tools to track the development of immune responses, I aim to 1) create a comprehensive single cell atlas of LN organization in homeostasis, 2) unravel the rules of lymphoid SC specification and organizer function, 3) determine the impact of LN architecture on protective immunity, and 4) determine how such organization is altered in asthma, a highly prevalent chronic inflammatory airway, since alterations in SC-immune cell intercellular communication could explain increased immunity to harmless allergens, in the face of reduce immunity to viral infection and vaccination. By combining my qualifications in SC biology and LN organization with the expertise of the host lab in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Human mini hearts: looking for culprits and victims in cardiac disease' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cardiac disease causes morbidity and mortality as frequently as cancer. Predicting cardiac arrhythmia and cardiac failure, understanding multicellular (patho)physiological mechanisms, and devising new treatments represent unmet needs in the field. Human induced pluripotent stem cells (hiPSC) could revolutionise the way we study human disease but unfortunately, they still fall short in recapitulating variable phenotypes and complex cardiovascular diseases. This is partly due to functional immaturity of hiPSC-derived cardiac tissues, shortage of methods for accurate functional analysis and inability to identify cell-type specific contributions to disease pathology. I will address these challenges in Mini-HEART. We recently assembled novel three-dimensional multi-cellular cardiac microtissues as an important step towards full maturation and used these to demonstrate that cardiac disease mutations might directly affect non-myocyte cardiac cells. However, application of hiPSC microtissues to precision medicine remains to emerge. Using a multidisciplinary approach, I will combine isogenic hiPSC, their differentiation into distinct cell types of the heart, multifaceted biophysical assays, and tissue engineering to prove cell-type causality of disease and identify new molecules targeting the culprit cells to rescue the disease phenotype. I plan to use our unique complex hiPSC-cardiac microtissue to 1) identify and synthetically enhance maturation mechanisms; 2) reveal late arrhythmic and fibrotic phenotypes; 3) dissect cell-type specific contributions to complex cardiac diseases, including the role of macrophages and sympathetic nerves; 4) test two therapeutic strategies based on drug-tailoring and gene editing, to modulate the disease phenotype.  Together, Mini-HEART will crea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced flow meter to measure the flow of liquids in partially filled pipes' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

All over Europe today there is a great need to accurately measure the amount of sewage water flowing through a pipe to retain tight control of the treatment process and thus ensure an efficient and environmentally safe operation. However, the current methods experience significant problems when trying to measure either open channel flow or the flow in partially filled closed pipes. In this context it is found that there is a great need for a simple, inexpensive and accurate flow measuring system that remains reliable in partially filled and open flow systems. The project aims to develop a flow meter based on high frequency radar technology using a partnership of organizations that combines proven research ability with market driven demands and consumer expertise. This partnership will give the project an excellent chance of success and will eventually lead to the exploitation of the proposed radar and signal processing technologies as well as widespread use of the flow meter.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Molecular Catalysis At Uea' under Sixth Framework.

assistant: **Concept**

Over the last 15 years the discovery of metallocene-based catalysts for the polymerisation of olefins has rejuvenated and innovated the polyolefin industry in an unprecedented way. Whole families of new polymer and copolymer materials that were previously inaccessible can now be made at will and with predetermined properties. These materials are now breaking into new types of applications, and consequently this is internationally a highly competitive research area. More recently, in addition to the well known and highly successful metallocene catalysts, a range of non- metallocene complexes have been developed which show high activity for the polymerisation of alkenes, copolymerisations of alkenes with CO, and for copolymerisations with polar monomers. These catalysts promise to produce new ranges of materials that are not accessible today, and consequently there is intense international research effort in this area. In addition, industry realises that polymers derived from sustainable sources and which are biodegradable will be increasingly important. In particular, research in underway to find new, selective catalysts for the synthesis of polyesters, notably polylactide from biomass. Many of the non-metal locene catalyst types suitable for olefin polymerisation are equally suitable here. The work is likely to produce results with high industrial potential and exploitable IPR. As is in the nature of catalysis research, the distance from invention to implementation and wealth generation can be very short for successful catalysts. The project will provide high-quality scientific training in an industrially highly relevant and sought-after area and reinforce the European research potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Breaking Barriers in Scalable Quantum Computing'.

assistant: **Innovation**

At Quobly, we are charting a realistic path toward large-scale quantum computers using our proven semiconductor manufacturing processes. Our solution addresses the critical need for a new computing paradigm in the face of rapidly advancing artificial intelligence and big data technologies. We have developed silicon spin qubits with integrated on-chip control electronics, implemented on CMOS FD-SOI technology. Our ground breaking innovation, protected by 40 patents, is the result of two decades of rigorous European research and development. Our methodology involves modifying only 10% of standard semiconductor fabrication processes, enabling us to leverage existing infrastructure for the efficient and cost-effective production of quantum processors. We have already achieved significant milestones, including the successful demonstration of one and two-qubit gates, the fabrication of four-qubit chips, and the seamless transfer of processes from our pilot line to a commercial foundry. We have set ambitious targets in our development roadmap, aiming to demonstrate a 100 physical qubit chip by 2027 and a 1000 logical qubit chip by 2030. These advancements will facilitate real-world applications of quantum computing in medical research, drug discovery, mobility optimization, energy management, and other fields critical to Europe's technological sovereignty and economic competitiveness. Quantum computing offers a once-in-a-generation opportunity for Europe to leap ahead in the global tech race. With EIC Accelerator support, we will ensure that the next wave of world-changing innovations will be made in Europe


**Keywords:** quantum computing,  quantum technology,  fault tolerance,  qubits,  quantum error correction,  Silicon Spin Qubits, FD-SOI Technology, CMOS Integration, Fau
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Citizen Sense Air Monitoring Kit'.

assistant: **Objectives**

In January 2013, the five-year ERC funded project Citizen Sense was launched, investigating the role of low-cost and digital monitoring technologies in facilitating and organising new types of environmental engagement. This proposal brings together a comprehensive citizen-sensing toolkit for users to undertake air quality monitoring that realises the social and environmental potential of these technologies. With the benefit of five years of intensive and cutting-edge research, the Citizen Sense research project is exceptionally well positioned to develop an AirKit, thereby bridging the gap between our research and the early stages of innovation in order to realise the innovation potential of the project. Our research pioneers new strategies of citizen-led monitoring and data analysis that join up hardware and software developments along with social innovations in order to produce an AirKit toolkit that has the potential to revolutionise community monitoring infrastructures and practices. This PoC will help to establish the viability of the AirKit, to refine and address technical issues, and to consolidate the overall direction of the AirKit.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Electronic, Didactic and Innovative Platform for Learning based On Multimedia Assets' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Distance learning has become a great ally in the current Pandemic situation. The e-DIPLOMA project will establish the e-learning in an upper quality level in a three years’ research project, posing the use of Augmented Reality/Virtual Reality, Artificial Intelligence (Machine Learning/Deep Learning), Interactive Technologies, chatbots and gamification in a newly designed e-learning platform. This project will use techniques and technologies previously proven successfully in the broadcasting, gaming, and eSports industries. They will be adapted to the educational world developing innovative learning practices. A co-creation methodology will be used to include the main educational actors (teachers, educators, pupils, families, course providers and policy makers) and their social relationships. Inclusiveness, accessibility and sustainability will also be taken into account. This project states that knowing the potential, opportunities, barriers, accessibility and risks of use of emerging technologies for teaching and learning in educational practices, including necessary innovation skills for teachers, will support their digital transformation and will contribute to understanding the social, ethical, political and economic impacts of digital practices, and, in addition, it will increase the resilience of the educational world accepting the benefits of this digital change. As well, this project will consider the needs for an adequate teacher training in relation with new educational technologies, analyzing the shifting role of teachers, trainers and educational leaders in the digital transition affecting education and training as well as their training needs, including digital and leadership skills, required in an emerging society of permanent and quick technological change