RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Intelligent Stochastic Computation Methods for Complex Statistical Model Learning' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Very recently, it has been claimed that the Bayesian paradigm has revolutionized statistical thinking in numerous fields of research, as a considerable amount of novel Bayesian statistical models and estimation algorithms have gained popularity among scientists. Despite of the evident success of the Bayesian approach, there are also many research problems where the computational challenges have so far proven to be too exhaustive to promote wide-spread use of the state-of-the-art Bayesian methodology. In particular, due to significant advances in measurement technologies, e.g. in molecular biology, a constant need for analyzing and modeling very large and complex data sets has emerged on a wide scale during the past decade. Such needs are even anticipated to rapidly increase in near future with the current technological advances. The prevailing situation is therefore somewhat paradoxical, as the theoretical superiority of the Bayesian paradigm as an uncertainty handling framework is widely acknowledged, yet it can be unable to provide practically applicable solutions to complex scientific problems. To resolve this issue, the research project will have a focus on stochastic computational and modeling strategies to develop methods that overcome problems associated with the analysis of highly complex data sets. With these methods we aim to be able to solve a multitude of statistical learning problems for data sets which cannot yet be reliably handled in practice by any of the existing Bayesian tools. Our approaches will build upon recent advances in Bayesian predictive modeling and adaptive stochastic Monte Carlo computation, to create a novel family of parallel interacting learning algorithms. Several significant statistical modeling problems will be considered to demonstr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Functional liquid crystal elastomers' (FULCE).

assistant: **Innovation**

The young pre- and post-doctoral researchers will obtain specialist training in the group laboratories and by Network-wide workshops focused on programme objectives. The appointed young researchers will be based in one of the participant laboratories. However, a substantial part of their training will include stages at other participant groups to use the available advanced techniques. Therefore, cross-disciplinary training will be achieved. The training of young researchers in the frame of the present project will produce scientists with a broadened perspective of techniques in molecular and material design and characterization. The industrial relevance of functional liquid-crystalline elastomers as new materials will be addressed and placements of researchers at the companies which support this research training programme will be sought. Ultimately this Network which is considered as laboratory without wall will produce researchers having high level of specialist trainings, and a critical awareness of related scientific disciplines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Modular architectures for natural language description and artificial intelligence' under Sixth Framework.

assistant: **Concept**

Our research topic is placed within the theory of formal languages, specifically we center our attention on three modular architectures defined within that field in the last years: membrane systems, colonies and eco-grammar systems. We intend to show tha t those three modular architectures can be very useful in the fields of natural languages and artificial intelligence The main research objective of the proposal we present here may be said to be the demonstration that modular architectures developed in the last years within field of formal languages may be of great utility in the description of natural languages and in the field of artificial intelligence. The overall goal of the project is to offer simple theories for describing natural languages in o rder to make easier their manipulation and their implementation in natural language processing systems. Specifically, what we intend to do is the following: 1.We want to show that membrane systems may reveal as a useful tool for the description of diffe rent levels of natural languages. We would like to apply membrane systems to the description of natural languages in order to develop something that may be called biological linguistics. 2.We intend to use colonies in order to generate natural language s and reconcile two apparent different conceptions in present-day linguistics â¿¿the one that regards natural languages as infinite objects, and the one that regards them as finite objects. 3.And finally, we want to use eco-grammar systems in the field of human-computer interfaces in natural languages. We intend to show that it is possible to use a modular formal-language-theoretic tool to model conversation and that such a formal device may be useful for the designing of effective and pleasants compu ter dialogue systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Computational Dissection of Effective Circuitry and Encoding in the Retina for Normal and Restored Vision' (CODE4Vision).

assistant: **Concept**

Understanding how neural circuits process and encode information is a fundamental goal in neuroscience. For the neural network of the retina, such knowledge is also of concrete importance for the development of vision restoration therapies for patients suffering from degeneration of photoreceptors. Artificial stimulation of retinal neurons through electronic implants or inserted light-sensitive proteins (“optogenetics”) aims at reconstructing natural transmission of visual information to the brain. Recreating natural retinal activity, however, will require a thorough understanding of the complex and diverse neural code of the retina. The challenge lies in deciphering the various nonlinear operations and dynamics in the around 30 parallel signalling streams that emerge from the retina, represented by as many types of ganglion cells, the retina’s output neurons.The CODE4Vision project will tackle this challenge by identifying the effective connectivity between the different types of retinal ganglion cells and their excitatory presynaptic partners, bipolar cells, and by determining the features of information processing between these neuronal layers. We will characterize the layout of bipolar cell inputs to large populations of ganglion cells with novel analyses that we derive from computational statistics and machine learning. We will then study the nonlinear and dynamical features of these connections by designing closed-loop experiments that automatically adjust visual stimuli to the identified layout of bipolar cells. These analyses will be supplemented by direct measurements of connections through simultaneous bipolar and ganglion cell recordings. The results will pave the way towards new models of how the retina encodes natural visual stimuli. Finally, we will apply
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Mechanism of facilitated homology search and the logic of its meiotic regulations'.

assistant: **Objectives**

DNA double-strand breaks (DSB) repair by homologous recombination (HR) entails identification of an intact homologous template DNA molecule in the genome. Homology search is guided by the DSB-flanking ssDNA sequence assembled into a RecA-family nucleoprotein filament (NPF). A biased version of this process, regulated in an ill-defined manner by chromosomes’ structure and meiosis-specific HR proteins, also underlies homolog recognition and recombination during meiosis I in most examined eukaryotes. Despite its centrality for genome maintenance and sexual reproduction, how homology search operates in cells and the nature of its meiotic regulations are largely unknown. Our goal is to solve these two major biological conundrums with a simple idea: that substrate properties (chromatin composition and motion) provide cues for search simplification and regulation.First, we will address the existence of a homology search facilitation mechanism based on combined (i) DNA occlusion by nucleosome and (ii) seeding of homology search by pioneer transcription factors (WP1). These insights will be applied to accelerate yeast evolution and improve gene-editing. Second, we will address how uncoordinated movements of semi-rigid meiotic chromosomes can generate mechanical cues underlying HR regulations that result in patterned recombination between homologs (WP2). The experimental strategy will involve extensive genetic engineering and large synthetic chromosomal regions for targeted alteration of chromatin composition, chromosome physical properties and chromosome motion in cis. Novel genomic and molecular approaches we developed to directly detect transient HR intermediates in yeast make this project uniquely feasible. This work should elucidate enigmatic interplays between chromosome bi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sustainable, affordable and code compliant 3D printed houses' (2014-2020).

assistant: **Concept**

3D printing has already revolutionized several industries and achieved unprecedented speed of delivery, quality and cost reduction. It has experienced a remarkable technological development in the last few years, being possible to find applications in various sectors, especially in the automotive, healthcare, aerospace or machines and tooling. 3D printing technology is therefore considered mature in high value products, although it has not yet been successfully transferred to the construction business. This is where A3D is positioning itself. A3D builds homes at fraction of the traditional cost, using sustainable materials and done on-site, reducing transportation costs, pollution, and waste. A3D has developed novel lightweight concrete formulations and 3D printing system able to build on site code compliant, sustainable and affordable houses. Our groundbreaking solution has been recognized by urban developers who are seeking to provide affordable and sustainable homes. Now, successful commercialization requires demonstrated field results. Through the feasibility study phase, we will establish the roadmap to build a full scale OVO Habitat (our first optimized design) ready to be commercialized.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Management, Orchestration and Supervision of AI-agent COmmunities for reliable AI in software engineering' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The reliable application of LLM-based agents to SE requires a tremendous increase in their accuracy and minimisation of their bias. While LLMs continue increasing in size and performance, it seems that phenomena like hallucinations of a single agent are substantially inevitable, since they are linked to the fundamental inference mechanism in generative models. On the other hand, evidence starts accumulating about the possibility of achieving the required performance by collaboration and debate among groups of agents. As it happens among humans, quality of work increases with specialisation of workers on tasks, organised collaboration, and discussion among workers with different backgrounds. Differently from humans, the instantiation of multiple required AI agents, and the collaboration and discussion among them, are very fast and cheap, making this approach particularly convenient.MOSAICO proposes the theoretical and technical framework to implement this approach and to scale it to very large groups of collaborating agents, i.e. AI-agent communities. The developed solutions are composed into an integrated MOSAICO platform, handling communication, orchestration, governance, quality assessment, benchmarking and reuse of AI agents. MOSAICO is integrated with existing development environments, to present the results to software engineers, and allow expert users to intervene in the AI decisions.The performance and reliability of MOSAICO technologies and tools to achieve given software engineering tasks are assessed within 4 different use cases scenarios coming from immersive technologies, bank/financing, aerospace and Internet of Things sectors.The long-term adoption of MOSAICO results and technologies will be ensured by open sourcing the code and fostering an open collabora
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'European partnership for autologous chondrocyte implantation'.

assistant: **Objectives**

Injuries to the articular cartilage of major joints are difficult to treat and with time can lead to osteoarthritis. The proposal is to support the further collaboration of six European partners to improve and to extend the tissue engineering technique of autologous chondrocyte implantation (ACI) for the long-term repair of articular cartilage defects. This has the potential to improve the activity and quality of life of the individual and to reduce the long-term costs of healthcare across the European Community. Central to the proposal is the establishment of a common database of patient symptoms, surgical and biological variables and outcome measures, together with a regular Intranet link over which the data will be discussed. The concerted action will deliver harmonized guidelines on patient selection and surgical technique, and recommendations for good laboratory practice in autologous cell culture. Further objectives are to enhance training, develop skills and to encourage the development of ACI in new European centres.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development and use of a microchip for molecular genotyping' (1994-1998).

assistant: **Concept**

- To develop a specific and cost-effective technology for detecting single nucleotide polymorphisms for genetic diagnostics and gene mapping by combining the AFLP and solid-phase minisequencing methods. - To utilize the AFLP technology for the identification of novel single nucleotide polymorphisms and for the amplification of target material. - To develop a micro-array format of the solid-phase minisequencing method. - To show the feasibility of the technology by analysing population samples for Finnish disease causing point mutations and for Y-chromosomal and autosomal haplotypes.For future molecular diagnostic purposes the aim will be to generate many data points reliably and at low cost. We will develop a technology for the simultaneous detection of large numbers of single nucleotide polymorphisms (SNPs) in a micro chip format. To achieve this goal we will utilize the advantages of the AFLP and solid-phase minisequencing methods. The AFLP technology allows co-amplification of thousands of target molecules simultaneously. The single nucleotide primer extension reaction used in the minisequencing assay alleviates the problem of low specificity of hybridization based methods. The project will consist of two phases. In its first phase the basic technology will be developed. The AFLP technology will be used to identify novel Y-chromosomal and autosomal SNPs and to enable multiplex amplification of genomic target sequences spanning the identified SNPs. A multiplex AFLP system will also be developed for amplification of DNA fragments spanning 50 disease causing mutations that are prevalent in the Finnish population. The minisequencing technique will be employed to acquire the selectivity and sensitivity to interrogate a complex mixture of multiplexed target material for id
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Unraveling Parkinson´s disease diagnostic' (UNMASK) targeting Horizon Europe.

assistant: **Abstract**

Parkinson´s disease (PD) is a progressive, chronic, and debilitating neurodegenerative disease for which there is no cure and no diagnostic test available. About 10 million people live with PD worldwide (1.2 million in Europe), and this number is expected to double by 2030 due to the aging population. PD has a high social and economic burden, and  there is the need to improve PD timely detection and diagnosis, especially in young people.UNMASK aims to validate the technological and business feasibility of the olfaction-inspired technology developed in the ERC Starting Grant SCENT by establishing the proof-of-concept for the non-invasive and fast PD diagnostics. To accomplish this, we will approach the project from both Technical and Business perspectives, with a perfect synergy between the research and business teams, and a close contact with clinical collaborators and stakeholders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Monsoon, Upwelling, Silicon and Carbon cycling: climate driven interplays in the Arabian Sea up to the last InTerglacial' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

In the Arabian Sea, the South West Monsoon (SWM) is active during summer and drives the Somali-Arabian Upwelling System (SAUS). The SAUS brings cold, deep and nutrient-rich water masses to the Indian Ocean’s surface, fuelling siliceous microplankton or silicifiers.  Silicifiers (mainly diatoms and radiolarians), are an important component of the soft tissue pump, a biological mechanism that lowers atmospheric CO2 concentrations. Despite the key role of this soft tissue pump in monitoring global climate and the socio-economic impacts of the SWM and SAUS in middle East and Eurasia, little is known about the monsoon, upwelling and soft tissue pump variability in strength relative to past climate and how they may evolve in the future due to global warming. To palliate this problem, MUSiC ArT proposes to use state-of-the-art technologies and methods to deconvolute the influence of climate on the SAUS and SWM intensity and associated-impacts on siliceous productivity over the last 150,000 years, covering the last interglacial period. The project aims to carry out innovative micropalaeontological and geochemical analyses on two sediment cores of the collections available at the Museum National d’Histoire Naturelle (MNHN, Paris, France). During the outgoing phase at GNS Science (New-Zealand), Artificial Intelligence and conventional microscopy will be used to generate census radiolarian and diatom counts. During a secondment at the University of Lausanne (Switzerland), isotopic ratios of 230Th and 232Th will be measured. For the return phase at the MNHN, diatom counts and high-quality imagery on microfossils will be completed and the isotope ratio of Silicon (δ30Si) and the Ge/Si ratio will be analysed on handpicked monospecific radiolarian and monogenus diatom samples. With th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Modification of starch synthesis and yield in wheat endosperm' to be submitted under Fifth Framework.

assistant: **Abstract**

The aim of this project is to improve the production of starch in wheat through manipulation of key components involved in regulating its synthesis, and an understanding of transcriptional controls, which regulate these components. In particular, the project focuses on factors, which determine the concentration of ad glucose (adpg) in wheat endosperm. Adpg is the immediate soluble substrate for starch synthesis in the amyloplast and affects both the rate of synthesis and the quality of starch produced. the expression of particular enzymes and amyloplastic translocations will be modified by transformation of wheat. Laboratoryu and fields trials will be conducted to determine effects on yield and starch functionality. The molecular mechanisms which control the expression of particular genes will be delineated. The projects bring together 6 partners from academia and industry and clear exploitation plans are in place to optimise the benefits of this research, which will lead to a decrease in production costs and environmental impact in the Eu.