RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Harnessing Novel Micropeptides in Cardiomyocytes to promote Cardiac Regeneration' (2021-2027).

assistant: **Innovation**

Despite advances in clinical care, heart failure consequent to myocardial infarction remains a leading cause of mortality worldwide. Absence of cardiac regeneration post-infarction is mostly explained by the reduced mitotic potential of adult cardiomyocytes, that, in comparison with their embryonic counterparts, have an accumulation of morphological, metabolic and biochemical adaptations that render them recalcitrant to proliferation. Devising tools to precisely control the maturational status of cardiomyocytes would enable novel therapies for cardiac regeneration, either by stimulating cell cycle reentry of pre-existing cardiomyocytes, or enhancing the maturational status of cardiomyocytes derived from induced pluripotent stem cells for cell therapy. Novel.CaRe will explore the therapeutic potential of micropeptides, a novel class of proteins that, despite their small size, can play major cellular roles. Based on extensive preliminary work, I propose an ambitious interdisciplinary research program bridging advanced omics, animal models, human samples, bioinformatics, cellular phenotyping and innovative strategies for gene therapy. We will apply new translatomics and proteomics approaches to identify micropeptides conserved across species and modulated during cardiomyocyte maturation, define their cellular functions and test their potential to induce proliferation of cell cycle withdrawn cardiomyocytes or enhance maturation of stem cell-derived cardiomyocytes. In a high-risk, high-gain part of the project, we will develop a novel approach for gene therapy enabling time-controlled, cardiomyocyte-specific expression of a combination of micropeptides normally expressed by embryonic cardiomyocytes and assess if this strategy successfully promotes regeneration of the adult h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Heterogenous Photo(electro)catalysis in Flow using Concentrated Light: modular integrated designs for the production of useful chemicals' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The aim of this project is to develop and model an integrated modular system based on continuous-flow heterogeneous photo(electro)catalytic reactors to produce relevant chemicals such as ethylene in the chemical sector, precursor to ""green plastics"" and many other high-value chemicals using abundant resources such as water, carbon dioxide and light. We aim at delivering cost-efficient small-scale systems for intermittent operation to respond to the needs of rural, isolated territories, and distributed manufacturing. Novel multifunctional photo(electro)catalytic materials integrated into practical and scalable reactors are required in Europe to maintain the technological leadership in chemical manufacturing, while ensuring the deployment of sustainable processes which meet circular economy and green industry for a low-carbon future. FlowPhotoChem will use the expertise of the partners to design, model, construct and validate an integrated modular system with improved energy efficiency and negative CO2 emissions, since concentrated CO2 will be valorised to high-value chemicals. The integrated system will be studied from a life cycle analysis perspective to quantify such effects, and to include a techno-economic study to quantify the cost of the technology and compare with comparable renewable solutions for the production of the same/similar chemicals.""


**Keywords:** Materials engineering, flow reactors, modelling, solar chemicals, photoelectrochemistry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Study of the indirect and direct influences an climate of anthropog enic trace gas emissions' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Objectives : To continue and extend in the previous SINDICATE projects to include chemical process descriptions in a state-of-the-art GCM (ECHAM4) to interactively simulate the climate effects of all relevant trace species in addition to CO2, like methane, ozone and aerosols. Brief Description of the Research Project : The anthropogenic increase of non-CO2 greenhouse gases causes a radiative forcing of climate that is approximately equal to that of CO2. On the other hand, increasing aerosol abundances cause a significant negative climate forcing. Not only the signs of these forcings, but also their geographical and height distributions can be very different and thus lead to a different climate response. General circulation model (GCM) studies, in part by this group, have shown that by accounting for anthropogenic changes in aerosols and stratospheric ozone, in addition to the long-lived greenhouse gases, the comparison between GCM results and observations has substantially improved. In order to further improve the quantification of climate effects from non-CO2 greenhouse gases and aerosols relative to CO2 the sources, transformations, transport and removal processes of radiatively and chemically active trace species have to be simulated explicitly using a general circulation model. A high resolution version of the chemistry-GCM will be further developed to simulate the ozone chemistry and dynamics of the stratosphere and interactions with the troposphere. Ozone and aerosol simulations will be extensively validated on the basis of in situ measurements and observations from satellites. The climate forcings from historical reconstruction of trace gas emissions will be calculated with the chemistry-GCM. Furthermore, we will perform interactive (transient) chemistry-climate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Nanostructured molecular decoders for the quantitative, multiplexed, layer-by-layer detection of disease-associated proteins' (Immuno-NanoDecoder).

assistant: **Concept**

The long-range goal of this project is to develop a molecular nanodevice, based on nucleic acid-protein conjugates, for the multiplexed, quantitative imaging of biomarkers in tissue samples and cultured cells.The Immuno-nanodecoder will be used for the accurate molecular characterization of skin cancer (melanoma) and glycogenosis type II cellular models and to evaluate the in vitro response to experimental therapies.The nanodevices (nanodecoders) will consist of self-assembled DNA nanostructures that can reversibly change their fluorescence signal output in response to hybridization to nucleic acid sequences, or to a specific enzymatic reaction.  Each nanodevice will be coupled to a specific molecular probe, such as an antibody, peptide, or protein that uniquely recognize disease biomarkers. The coupling will allow the nanodecoder to detect biomarker presence and distribution in cells and tissues, in a layer-by-layer fashion, using optical fluorescence microscopy. The number of biomarkers that can be detected will be limited only by the capacity to design nanodecoders with differing specificities, which is essentially unlimited. The creation of nanodecoders and optimization of their function will greatly advance biomarker imaging, which currently lacks a high-throughput, convenient method for the in situ, quantitative microscopic analysis of altered tissue regions. This project will be driven by knowledge exchange and the expertise of an interdisciplinary team comprised of both early-stage and experienced university and hospital researchers.Complementary research programs, ranging from nanotechnology to molecular medicine and pathology will support each step of the developmental and applicative parts of the project towards the achievement of its objectives. Funding of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'European Training and Research Centre for Imported and Highly Contagious Diseases'.

assistant: **Objectives**

To ensure that the European Union is able to respond appropriately to possible misuse of biological agents or outbreaks of rare, but deadly tropical diseases, there is a need to provide secure and safe laboratories with associated research competencies to develop and maintain expertise in this field. The Bernhard Nocht Institute for Tropical Medicine (BNI) in Hamburg is an internationally recognised centre of such expertise and is host to one of only six bio-safety level 4 labs (BSL 4) in the EU. The BNI has received planning permission for a 5000 m2 building extension to house BSL 4 and BSL 3 laboratories and a remodelled treatment centre for viral hemorrhagic fevers, thereby creating an interdisciplinary research centre environment unique in Europe. Th e extension is to be financed by German Government authorities. This application is for additional financial resources from the Support for Research Infrastructures Programme to permit the optimal equipping of this facility which otherwise due to the fun ding constraints set nationally is very limited. The infrastructure measures will support the international recognition of BNI as a European Training and Research Centre for Imported and Highly Contagious Diseases (EUTRICOD). Due to the current perceived international security threats, several Member States are considering to establish BSL 4 facilities. It is not clear that such facilities need or can be established in many centres around Europe, and indeed for security and safety reasons this may not b e desirable. Instead investment in central facilities to maintain international leadership and open up access to researchers, is for Europe as a whole a more optimal strategy in line with the key objectives of the Programme as well as the development of the ERA.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Photoelectrosynthetic processes in continuous-flow under concentrated sunlight: combining efficiency with selectivity' (SunFlower).

assistant: **Innovation**

To be the first CO2-neutral continent by 2050, Europe needs to develop and implement disruptive new technologies, based on scientific breakthroughs. In this regard, utilization of CO2 and organic waste as feedstock to generate valuable products will play a key role in turning the chemical industry on a more sustainable, circular path. In the SunFlower project, we are going to demonstrate that two high-value processes (CO2 or CO reduction and glycerol oxidation will be studied first) can be synergistically coupled to produce chemicals (such as ethylene and lactic acid) and fuels, using novel photoelectrode assemblies (both photocathodes and photoanodes), original photoelectrochemical (PEC) device architectures, and automated processes. The SunFlower project is based on the following three hypotheses:1. Proper engineering of continuous-flow PEC cells operating under concentrated sunlight will allow current densities similar to the electrochemical (EC) methods.2. One semiconductor alone can supply the necessary energy input for bias-free operation of PEC cells, while generating two high-value products.3. PEC methods can provide superior selectivity compared to their EC counterparts, even at high current density operation (as the current density and potential can be decoupled).To validate our hypotheses, we are going to use for the first time:• The pairing of two high-value generating redox processes (none of them being H2 or O2 evolution).• Concentrated sunlight (which has only been used for water-splitting so far).• Custom-designed and developed PEC cells, elaborating on the photo-gas diffusion electrode concept.• Machine learning, based on the broad dataset collected by the sensors built in the PEC system, optimizing the performance at a system level.The proposed combina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Recirculated tissue macrophages (TiMa) in blood: Novel approach to early diagnosis and treatment monitoring in oncology' (TiMa) targeting Horizon 2020.

assistant: **Abstract**

In the ageing European population, cancer has become the most common cause of death. Consequently, screening programs aim at early detection of cancer, while scanning/imaging technologies, serum assays and regular biopsies aim at monitoring of treatment effectiveness to improve cure rates and increase quality-of-life, thereby also attempting to reduce health care costs. However, in many cases the screening and monitoring methods do not provide sufficient sensitivity and specificity. Consequently novel diagnostic techniques are required.Completely Novel Concept: Sensitive intra-tissue total body scanning is continuously performed by our immune cells, particularly by monocytes and macrophages. Tissue macrophages (TiMas) continuously phagocytize and digest apoptotic cells and tissue debris. In cancer, many more TiMas are present to keep the involved tissue debris-free. When TiMas have fulfilled their local tissue-cleaning task, they can migrate via lymph vessels to lymph nodes and potentially recirculate to the blood stream, where they can be detected by flow cytometry and evaluated for the contents of their phagolysosomes.With State-of-the-Art technologies, this high-risk project aims to unravel phagocytosis of cancer cells, their digestion into tissue-specific and/or cancer-specific protein fragments, the migration/recirculation of TiMas to blood, and the detection of intra-phagosomal protein fragments in blood TiMas by antibodies. Building on this information, flowcytometric scanning of blood TiMas (TiMaScan) will be developed into a novel tool for early diagnosis and treatment monitoring in oncology, focusing on colon, lung, breast and prostate cancer. TiMaScan diagnostics will be minimally-invasive (~1ml of blood), rapid, accurate, broadly available and cost-effective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced satellite mobile systems-task force specific support action' (MOSSA).

assistant: **Innovation**

The Advanced Satellite Mobile Systems Task Force (ASMS-TF) is an independent, industry-led body, committed to the successful introduction and development of advanced (including 3G and beyond) satellite mobile communications systems and services. The TF was formed in March 2001, at the initiative of EC and ESA. Some of the goals of the TF are to coordinate ongoing and future RandD efforts and to provide inputs to entities like the EC and ESA in support of future MSS development.Thus, ASMS TF members are in a key position to foster the link between overall TF activities and EC works on related RTD. In this context, a group representing TF members, as decided by the TF Steering Panel, is presenting the MoSSA proposal to provide, within the FP6, an industry effort coordination point, with respect to all matters related to the place of satellites in mobile communication systems and applications.The project aims to contribute to the implementation of activities of the FP6, the analysis and dissemination of results and to the preparation of future activities with a view to enable the ERA to define and achieve the RTD strategic objectives as far as satellites are concerned. MoSSA places emphasis on the following support actions:-to promote and facilitate the dissemination, transfer, exploitation, assessment and broad take up of past and present FP results, by using the power of the TF members, traditionally fully engaged in RTD activities related to ASMS systems; particular emphasis will be done on promotion of active participation of FP6 projects in related standardization and regulatory bodies, as CEPT and ETSI and other satellite interest bodies like SAP as well as-to link up with other appropriate fora-to contribute to strategic objectives, notably regarding the ERA-to prep
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'RELatinG quALIties and quantities by resource Approximation' (REGALIA).

assistant: **Innovation**

Qualitative type systems are a widespread technique exploited in the study of programming languages. Types allow to obtain relevant information on the behaviours of programs, such as termination of the evaluation. Quantitative type systems are used to achieve additional information on complexity and resource consumption. While these two families of type systems have been deeply studied, their interaction is still far to be properly understood. Given a program typed in a qualitative way, can we extract quantitative information from it in a compositional manner? This very natural and fundamental question has not received any appropriate answer yet. REGALIA aims to answer the question, deepening our understanding of the relationship between these two kinds of type systems. In order to do so, REGALIA will further develop the theory of resource approximation, by extending Girard's approximation theorems to proofs with cuts and by establishing a translation algorithm between qualitative systems and quantitative ones. I shall then exploit these results to define modular methods to study programming languages, alternative to Tait-Girard reducibility, that will offer quantitative interpretation of relevant qualitative systems in the context of both pure and effectful computation.


**Keywords:** Programming Language Theory, Type Systems, Resource Approximation, Quantitative Bounds
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Supporting new Opportunities for Waste Heat And cold valorisation Towards EU decarbonization' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

SO WHAT main objective is to develop and demonstrate at TRL8 an integrated software which will support industries and energy utilities in selecting, simulating and comparing alternative Waste Heat and Waste Cold (WH/C) exploitation technologies that could cost-effectively balance the local forecasted H&C demand also via RES integration. The SO WHAT integrated tool will be designed to support industries, and energy utilities in 1) auditing the industrial process to understand where WH/WC could be valorised 2) mapping the potential of locally available RES sources to be integrated with WH/WC potential 3) mapping the local forecasted demand for heating and cooling 4) define and simulate alternative cost-effective scenarios based on WH/WC technologies also leveraging TES introduction 5) evaluate the impacts (in terms of energetic, economic and environmental KPIs) that the adoption of the new scenarios will generate against the current situation (i.e., baseline) both at industrial and local level 6) promoting innovative contractual arrangements and financing models to guarantee economically viable solutions and less risky investments. To do so SO WHAT will capitalize already existing tool and knowledge from previous research experiences (REEMAIN, PLANHEAT, REUSEHEAT, CELSIUS…) and the expertise of 11 industrial validation sites from different REII/ non-REII sectors (petrochemical, chemical, metallurgic, food etc.) that will be involved in the project to validate the tool and provide relevant insights for its development. SOWHAT tool will be built indeed following a participatory approach involving both National clusters from Spain, Portugal, Belgium, Sweden, Romania (composed by local industries, public authorities/energy agencies, energy utilities/ESCOs) and external stakeh