RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cell compartmentalization, individuation and diversity' (BARRAGE) targeting Seventh Framework.

assistant: **Abstract**

Asymmetric cell division is a key mechanism for the generation of cell diversity in eukaryotes. During this process, a polarized mother cell divides into non-equivalent daughters. These may differentially inherit fate determinants, irreparable damages or age determinants. Our aim is to decipher the mechanisms governing the individualization of daughters from each other. In the past ten years, our studies identified several lateral diffusion barriers located in the plasma membrane and the endoplasmic reticulum of budding yeast. These barriers all restrict molecular exchanges between the mother cell and its bud, and thereby compartmentalize the cell already long before its division. They play key roles in the asymmetric segregation of various factors. On one side, they help maintain polarized factors into the bud. Thereby, they reinforce cell polarity and sequester daughter-specific fate determinants into the bud. On the other side they prevent aging factors of the mother from entering the bud. Hence, they play key roles in the rejuvenation of the bud, in the aging of the mother, and in the differentiation of mother and daughter from each other. Recently, we accumulated evidence that some of these barriers are subject to regulation, such as to help modulate the longevity of the mother cell in response to environmental signals. Our data also suggest that barriers help the mother cell keep traces of its life history, thereby contributing to its individuation and adaption to the environment. In this project, we will address the following questions: 1 How are these barriers assembled, functioning, and regulated? 2 What type of differentiation processes are they involved in? 3 Are they conserved in other eukaryotes, and what are their functions outside of budding yeast? These
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Function of host cells during infection' under Fifth Framework.

assistant: **Concept**

Students joining this training site will gain unique expertise in microbiology, compromised- logy and cell physiology and are thus perfectly trained to unravel cellular mechanisms of host cell cooperation and defence during infection with intracellular pathogens
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Prevention and definition of autoimmunity through dipeptidyl-peptidase IV signaling'.

assistant: **Innovation**

Type-1 diabetes remains one of the most devastating childhood disease of the day. Despite over acentury of research into the condition diagnosis still carries with it a sentence to lifelong daily insulininjection. Despite its prevalence, medicine has yet t o offer preventative therapy for the condition.Dipeptidyl peptidase IV (DP IV) is a ubiquitous multifunctional membrane ectopeptidase withparticularly high expression levels on the endothelial lining of the vasculature and on the surface ofimmune cells. Th e aims of the current investigation are built upon several pieces of evidence:i. immune cells expressing DP IV have been implicated in the process of autoimmunityii. DP IV-inhibitors have been shown to suppress immune activationiii. DP IV-inhibitors have b een shown to augment the actions of the ß-cell enhancing peptides GIPand GLP-1, effecting enhanced secretory function, neogenesis and cell survivalThe aims of the current application are three-fold: to use DP IV-inhibitors as tools to both pry into therole of DP IV in development and function of cellular immunity; to investigate the unique therapeuticpotential of DP IV-inhibitors (combined immunosuppression and ß-cell enhancement) in the treatmentof type-1 diabetes mellitus; and, through establishment of an embryonic stem cell line containing atype-1 diabetes (NOD) genome, to generate NOD mice with a specific deletion of the DP IV gene. Inaddition to possibly establishing the first preventative therapy for type-1 diabetes mellitus, fulfillmentof these goals would represent major advances in a number of areas; first, deepening ourunderstanding of immune cell development and function as well as autoimmunity, whilst providingthe scientific community with a powerful tool for the investigation of the genetic under pinn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Electronic Doping of Soft Semiconductors' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

EDO will develop protocols for intentional, spatially controlled, and stable electronic doping in metal halide semiconductors.Electronic doping implies engineering of carrier density in semiconductors through the intentional introduction of a defect and it is necessary to achieve high performances in micro and optoelectronic technologies. Unlike established semiconductors, which are typically covalent solids, those belonging to the class of soft materials, such as molecules and polymers, forming van der Waals solids, and metal halide perovskites, forming ionic solids, host complex doping mechanisms. As a result, the design of free carrier density is far from being established and exploited in metal halides perovskites thin films. Intrinsic challenges, such as compensation and migration of defects, charge localization, phase segregation and the strong doping−processing relationship, may hide or hamper the designed doping process. Characterization and control of such phenomena require the combined knowledge of electronic, chemical and morphological/structural information, which is often missing. As a result, reports are often contradictory and advanced tools are in demand to draw a complete picture. Synchrotron facilities may help reaching the target, however, their limited access hampers direct feedback between synthesis and characterization.EDO will develop an unprecedent multimodal experimental tool, in laboratory environment, to quantitatively assess the doping and examine its impact on the optoelectronic properties of metal halides perovskites semiconductors. A photoemission microscope will be coupled to tunable coherent sources, covering the entire spectrum from NIR to soft X-ray radiation to map at nanometer scale the Fermi level shift, the electronic structure and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Solvated Ions in Solid Electrodes: Alternative routes toward rechargeable batteries based on abundant elements' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Storing large amounts of electrical energy is a major challenge for the forthcoming decades. Today, lithium-ion batteries (LIBs) are considered the best option for electric vehicles and grid storage but these rising markets put severe pressure on resource and supply chains. The principle of LIBs is based on solid electrodes separated by a liquid electrolyte between which Li ions are reversibly exchanged during charge and discharge. The efficient Li+ transport in the different phases and across the interfaces is essential for achieving a good performance. A fundamental difference between ion transport in solid phases and ion transport in solutions is that the ions are naked in the solid phase but solvated in the liquid phase. Recently major efforts have been initiated to adopt the successful LIB concept to other working ions such as Na+, K+, Mg2+, Ca2+ or Al3+. This is motivated by the promise of lower cost thanks to their abundance as well as in some cases higher energy density. The progress, however, is limited mainly due to an unfavourable mismatch between the solid electrode host structures and the ion radii or too large charge/radius ratios. Especially multivalent ions lead to severe lattice polarization frustrating ion mobility in solid electrodes.This project aims at a radically different concept, i.e. instead of naked ions, solvated ions will be intercalated into the electrodes. Solvent co-intercalation is traditionally considered as highly detrimental. Latest results, however, question the generality of this argument. The SEED project will explore the concept of using solvated ions in solid electrodes for the reversible storage of a variety of ions. As the solvation shell acts as electrostatic shield and can be tuned in its composition, lattice polarization can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Comprehensive Platform for Correlating Biomolecular Dynamics and Biomechanics with Multiscale Optical Spectroscopy' (MotionPicture).

assistant: **Innovation**

Measuring the molecular dynamics and interactions of biomolecules in live cells is crucial for understanding cellular mechanisms. While recent advances in super-resolution fluorescence microscopy have enabled molecular-level resolution in fixed samples, capturing dynamics in live cells remains a major challenge. Conventional methods for studying molecular dynamics struggle with high fluorophore concentrations, photobleaching, and the need for extensive prior knowledge about the setup and sample. In addition, measuring the molecular diffusion properties without knowing the local viscosity complicates the study of anomalous diffusion dynamics.The overall goal of the MotionPicture project is the development of a platform based on optical microscopy with massive information content to quantify molecular dynamics and local viscosity with unprecedented detail, speed, and ease of use. The project involves the construction of a photon-resolved microscope combining fluorescence and Brillouin microscopy. We will use various methods to shape and move the fluorescence excitation beam and tag every emitted photon with multiple signatures, such as spatial information, time of arrival, and energy. We will develop a deep-learning based analysis framework to extract molecular dynamics information from the high-dimensional data set. In parallel, we use label-free Brillouin microscopy to correlate the fluorescence data with the biomechanical properties of the same sample. Compared to the state-of-the-art, this project aims to derive a more complete picture of the molecular dynamics and in a faster, more robust, less phototoxic, and more user-friendly way.The unique combination of the fluorescence and Brillouin information will have significant potential for the study of biomolecular dynam
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Study of etching of polymers with a large area inductively coupled plasma discharge' under Fifth Framework.

assistant: **Concept**

The task of the applicant will be the determination of a process control and end point detection method for Reactive Ion Etching process. The knowledge and the experience that I learn from JRC will benefit my current and future research work. I have an excellent experience in material treatments by plasma and laser radiation, as well as a good theoretical and practical experience in plasma reactors, particularly ECR, which will be helpful for the project as a whole.The task of the applicant will be the determination of a process control and end point detection method for Reactive Ion Etching process. The knowledge and the experience that I learn from JRC will benefit my current and future research work. I have an excellent experience in material treatments by plasma and laser radiation, as well as a good theoretical and practical experience in plasma reactors, particularly ECR, which will be helpful for the project as a whole.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Jena initiative of applying molecular techniques for the analysis of variations of ecological processes in space' in the context of a Sixth Framework call.

assistant: **Objectives**

JEN-A-MACE is an inter-disciplinary project with the objective to develop a new area of competence at the Institute of Ecology (IOE) at the University of Jena that allows integrating the ecological consequences of spatial structure into models at various scales. The IOE seeks to complement its expertise at the interface between microbial ecology, animal ecology, and mathematics by recruiting experienced researchers trained in state-of-the-art molecular techniques and inverse modeling.The scientific objectives of JEN-A-MACE are- to develop molecular expertise in analyzing microbial populations with stable isotope probing;- to establish PCR-based microsatellite techniques for analyzing the population structure of insects and mammals;- to develop modeling approaches for the analysis of ecological consequences of spatial structure within animal and microbial populations.Thus, JEN-A-MACE links molecular knowledge across disciplines and dimensions by investigating local changes in microbial diversity, genetic input of dispersers in metapopulations, and constructing spatially explicit models.Since progress in biology demands molecular techniques, the establishment of this competence will expand the excellent standing of the IOE to successfully compete internationally. To achieve these objectives, JEN-A-MACE will bring young researchers to Germany, especially to Thuringia, an area of Europe isolated from the EU until 1989. Temporal overlap of the four experienced researchers will maximize the input of expertise into the existing groups.The tools and synergies developed in JEN-A-MACE will be made available to others for research training and knowledge transfer in environmental sciences. While already strong in community and theoretical ecology, the establishment of molecular too
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Can less be more?: Semiparametric and partial identification in panel data discrete response models with an application to consumer demand' (PartialIO).

assistant: **Concept**

In this project novel econometric panel data models of consumer demand will be developed. In particular, the determinants affecting individuals’ decisions will be examined when individuals are observed making decisions over time using new and less restrictive models. The new models will examine the role of inertia, habits and lock-in in choices and the importance of dynamics in decisions, when consumers choose from a set of alternatives offered in different quality levels. The methodologies in this project will allow the examination of substitution patterns not examined before.Traditional panel data demand models often use distributional and functional form assumptions for identification and estimation. If misspecified, these models can lead to interpretation and inference problems, jeopardizing the success and effectiveness in the policy decision-making processes of firms and governments. Semiparametric models that make fewer assumptions have increased credibility, however, can lose identification power hence partially identifying the parameters of interest. Such models can be applied to many different settings and datasets and do not rely on unfounded assumptions, making it clear what can be tested and what conclusions can be drawn from the analysis. This directly relates to one of the seven priority challenges identified by the EU as part of the H2020, related to health, demographic change and wellbeing, since accurate representation of individuals’ decision process has a direct effect on the welfare policies designed. This project will lead to publication outcomes in econometric theory and applied microeconometrics in terms of novel methodologies.  These methodologies will form the basis for a broad spectrum of theoretical and applied research in econometrics and mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel Fiber Cotton Coloration for a Revolutionary Sustainability Breakthrough in Textile Applications' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Cotton is the world's most important non-food crop, accounting for 35% of global fiber production, but it is environmentally demanding and resource-intensive. Its production, especially the dyeing process, pollutes and depletes water and soil resources. The current strategies for cotton dyeing still rely on old manufacturing processes that yield large quantities of chemical and water waste. Thus, it is urgent to seek sustainable alternatives to meet acceptable environmental and social standards.This Proof of Concept (PoC) project aims to prepare the commercialization of novel molecules able to modify cotton fibers in planta for textile applications, providing them with color. This innovative approach minimizes chemical waste associated with dyeing, plus achieving up to a 90% reduction in water usage through hydroponic cotton growth. By growing cotton fibers with built-in colors in hydroponic settings, we seek to pioneer a zero-chemical-waste dyeing process while significantly reducing water consumption. Our innovation addresses the fashion industry's need for distinctive, eco-friendly textile products, presenting exciting opportunities to meet the growing consumer demand for more sustainable products.For this endeavor, our objective is to craft a diverse set of molecules strategically designed to navigate and surpass inherent biochemical barriers. Moving forward, we will seek to demonstrate the efficacy of these novel molecules on cotton plants. Simultaneously, we aim to evaluate the commercial viability and potential market of HYDROCOLTON's groundbreaking innovation within the cotton value chain. We will validate our business model and commercialization plans with the constant engagement of relevant market stakeholders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Chemical Profiling of Inorganic and Pyrotechnic Explosives' (PyroProf).

assistant: **Innovation**

The criminal law system has shown interest in the recent scientific developments with respect to chemical profiling of explosives. This approach goes beyond explosive material chemical identification, providing key intelligence to a counter-terrorism or forensic investigation on the basis of chemical clues in the form of impurities and degradation products. Explosive profiling can reveal relationships between samples obtained from a crime scene and material associated with a suspect. If such profiles can be linked to the production process and the raw materials used such intelligence information can even assist law enforcement in stopping attacks from being successfully executed. However, explosive profiling is challenging since it requires suitable analytical strategies, unbiased interpretation of the results, substantial sample collections and comprehensive knowledge on the chemical variation of explosives, precursors and environmental background levels. The main research objective of the PyroProf project is to offer suitable analytical tools for the chemical profiling of inorganic explosives of forensic interest (e.g., ammonium nitrate based and pyrotechnic mixtures) for their use in forensic casework. This project will yield selective sampling strategies, novel separation methodologies by state-of-the-art CE-MS and IC-MS instruments, complementary statistical approaches and databases with further knowledge on explosive, precursor, and background compositions useful for forensic interpretation. This outcome will benefit the experienced researcher to boost his career as a professional researcher in the analytical and forensic chemistry fields as well as will have impact on the European society since the results will be disseminated and used to/by scientific and forens