RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The elucidation of the biological role of annexin and their complexes using a combination of structural and cell biology techniques' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. Although this common property may be due to highly conserved sequences, the existence of at least ten different annexins in the mammalian species suggests that they have specific and diverse biological functions. Specificity and diversity may be carried by the N-termini, different for all annexins, but may also be the consequence of interactions of annexins either with other annexins or other cellular partners. Indeed, the knowledge of the three-dimensional structure of the conserved core of some annexins has not given sufficient understanding of their biological function. To address the issue of the complexity and diversity of the biological functions of annexins, therefore, we wish to investigate the interactions of annexins with other proteins combining the following structural, cell and molecular biology methods: - preparation of annexins and interactive proteins by recombinant molecular techniques - production of large quantities of these proteins to a high degree of purity for crystallographic purposes - X-ray crystallography - low- and high-resolution electron microscopy - electrophysiology experiments (patch-clamping and calcium imaging) - static and dynamic fluorescence spectroscopy using synchrotron radiation - search for cellular partners of annexins using the yeast double hybrid system - immunolocalization of proteins within cells - transfection experiments on the partners for annexins: the overexpression of either a wild type or a mutated form of the partner. With the following aims: - the 3D structure determination of intact annexin molecules. - characterization of annexins in solution. - study of interactions between annexins and oth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'ACelerated COnvex OPTimization'.

assistant: **Objectives**

The amazing rate of progress in the computer technologies and telecommunications presents many new challenges for Optimization Theory. New problems are usually very big in size, very special in structure and possibly have a distributed data support. This makes them unsolvable by the standard optimization methods. In these situations, old theoretical models, based on the hidden Black-Box information, cannot work. New theoretical and algorithmic solutions are urgently needed. In this project we will concentrate on development of fast optimization methods for problems of big and very big size. All the new methods will be endowed with provable efficiency guarantees for large classes of optimization problems, arising in practical applications. Our main tool is the acceleration technique developed for the standard Black-Box methods as applied to smooth convex functions. However, we will have to adapt it to deal with different situations. The first line of development will be based on the smoothing technique as applied to a non-smooth functions. We propose to substantially extend this approach to generate approximate solutions in relative scale. The second line of research will be related to applying acceleration techniques to the second-order methods minimizing functions with sparse Hessians. Finally, we aim to develop fast gradient methods for huge-scale problems. The size of these problems is so big that even the usual vector operations are extremely expensive. Thus, we propose to develop new methods with sublinear iteration costs. In our approach, the main source for achieving improvements will be the proper use of problem structure.Our overall aim is to be able to solve in a routine way many important problems, which currently look unsolvable. Moreover, the theoretical de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Development of novel 3D vascularized cardiac models to investigate Coronary Microvascular Disease'.

assistant: **Concept**

Coronary microvascular disease (CMD) is a significant healthcare challenge, contributing to ischemic heart disease, the number one global cause of human mortality. CMD is associated with dysfunction of small coronary vessels, due to ageing, obesity and metabolic disease, that reduces blood flow and oxygenation in the heart. Despite its widespread impact on health, our understanding is limited to animal studies, which do not recapitulate the pathophysiology in humans, nor can they be used to reveal cellular crosstalk in a controlled manner. Thus, there is a critical need to develop a humanized in vitro model to mimic CMD. Advances in organ-on-chip and induced pluripotent stem cell (iPSC) technologies, together with our state-of-the-art 3D humanized vascular models, provide new opportunities to investigate CMD. 3DVasCMD builds on our expertise to develop a complex vascularized cardiac model, to reveal pathological mechanisms and novel therapeutic targets of CMD. By combining cutting-edge tissue-engineering approaches we will: 1) Develop and characterize a 3D vascularized cardiac model, 2) Determine the impact of known risk factors on the pathophysiology of CMD; 3) Develop a high-throughput system for cardiovascular drug screening. Our model will reveal cardiac tissue-vessel crosstalk by combining autologously-differentiated iPSCs in a controlled fluidic environment. This model will enable unprecedented study of ischemia, diabetes, and sex-hormone contributions to CMD using 3D in vitro tissues. Ultimately, a high-throughput version of our model, combined with machine learning, will predict the efficacy of therapeutic targets.Using an interdisciplinary approach, 3DVasCMD will impact our understanding of how microenvironmental and heritable risk-factors contribute to CMD.  T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'OpenSMESearch (OSS)' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

OSS (OpenSMESearch) aims to provide a platform to the online visibility problem facing by millions of micro SMEs in Europe. Despite they are regarded as the backbone of the European economy, important source for jobs, SMEs are losing online visibility with massive explosion of big data in the Internet era. This phenomenon is caused by two main factors:  1) more than 40% do not have a website yet and 2) they are not transparently shown in web searches, as the order of results is influenced by optimized, sponsored and paid business results. Therefore, small local businesses are suffering clear erosion in their individual sales, taxable sales for government revenue, which is based on local consumers (B2C) and services to other business (B2B). This problem is of vital relevance for the EU.OSS is our future flagship product based on pool of public and private data. OSS will be a dedicated search ecosystem for European SMEs, will provide transparent, relevant and global online visibility, facilitating the matching of business to consumers (B2C) and business to businesses (B2B), eliminating any disintermediation’s. OSS is crowd sourcing, ads free search model coupled with semantic database technologies built on the combination of both open and our private data sources. This product also has potential to extract commercial value from open data and increase private data profitability.The goal of OSS is to make local micro, SME knowledge globally visible in big data internet world. In this line, we present an analogy of our ambition. Wallet verses internet analogy: Big companies are like ""Bank cards & bills"" where as micro SMEs are like ""coins"". Most of the wallets are not having provision for coins likewise SME results are not getting enough visibility on global search platf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Control of assembly and charge transport properties of immobilized DNA' in the context of a Sixth Framework call.

assistant: **Objectives**

The goal of this proposal is to establish the basic conditions for DNA-based biotechnology-biotechnology. The programme which rests on biochemistry, advanced co-ordination chemistry, molecular spectroscopy, surface physics and theoretical chemistry comprises:(1) the optimisation of topology and dynamics of surface-immobilised DNA hybrids using a novel spectroscopic approach applying electrochemical and spectroscopic techniques in parallel;(2) the development of novel binding procedures of DNA to metal or semiconductor surfaces;(3) tailored modifications of DNA bloomers and assembly of complex DNA architectures as elements of biosensor devices;(4)high-resolution mapping of the metal/DNA interface;(5)the investigation of intra-hybrid charge transfer based on time-resolved optical spectroscopy;(6)the study of interfacial charge transfer using scanning tunnelling microscopy;(7)an assessment of the mechanism of electron transport in DNA hybrids and across metal/DNA interfaces based on NMR structure and sophisticated molecular modelling simulations The strong impact expected of this joint effort rests on the combination of different synthetic approaches, on the high level of structural resolution, time-resolved electron transport dynamics, topology and electrochemistry of surface-immobilized hybrids of DNA and its analogues and single molecules imaging techniques as well as on quantum chemistry and molecular dynamics simulations. Taken together, this so far unique combination of methods in experiment and theory will yield results crucial for existing and future medical diagnostics and DNA-based environmental biosensorics. In terms of immediate exploitation this CIDNA project will rest on novel robustness structures and analogues. In more general terms of DNA-chip technology t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Reversing Tumor Immunotherapy Resistance via TME Modulation', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

T cell infiltration and persistence in solid tumors are crucial for the success of T cell-based immunotherapies, yet the tumor microenvironment (TME) often suppresses T cell access and function. Our ERC-funded research has identified a G protein-coupled receptor (GPCR), activated by a metabolite commonly enriched in solid tumors, that substantially impairs T cells. We showed that inhibition of this GPCR enhances T cell infiltration, persistence, and cytotoxicity, thereby substantially improving the efficacy of CAR-T, TCR-T, and immune checkpoint blockade (ICB) therapies across tumor models of various cancer types.To advance these findings towards clinical applications, we developed monoclonal antibodies (mAb) against this GPCR, which exhibit potent blocking functions and high specificity. Our lead mAb effectively reactivates patient-derived tumor-infiltrating lymphocytes (TILs) against autologous primary tumor cells, underscoring its therapeutic potential.Project REVIVE aims to 1) humanize and optimize our mAbs target this GPCR, 2) conduct preclinical validation to assess efficacy and safety in advanced models, 3) develop predictive biomarkers for patient selection, and 4) establish a comprehensive intellectual property (IP) and commercialization strategy, integrating freedom to operate (FTO) analyses, market assessment, licensing opportunities, and industry partnerships to facilitate clinical translation. By executing these steps, REVIVE will generate an investor-ready, clinically viable, IP-protected antibody targeting this GPCR, supported by comprehensive preclinical validation and a biomarker-driven patient selection strategy. These outcomes will enhance the commercial attractiveness of our therapeutic candidate for licensing or spin-out opportunities, paving the wa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DEFINING THE MECHANISMS OF AGE-RELATED MUSCLE LOSS: FOCUS ON AUTOPHAGY' (MyoPHAGY).

assistant: **Innovation**

Muscle loss occurs in many diseases including cancer, AIDS, diabetes, renal or cardiac failure and sepsis. The wasting of muscle mass is characterized by the activation of an atrophy program that coordinates the ubiquitin-proteasome and autophagy-lysosome systems. The simultaneous activation of these systems allows the breakdown of contractile proteins and the removal of organelles. Ageing sarcopenia and frailty are also characterised by progressive muscle loss. However, the mechanisms that are at the base of this weakness are obscure. Sarcopenia results in a progressive loss of mobility that decreases the quality of life and has major economic and social consequences. In fact the age-dependent muscle atrophy favour traumatic events, accident, fracture or illness which lead to aged person to become hospitalised and bed-ridden or housebound, thus -having a high mortality in the year following their accident. The signalling pathways, which regulate loss of proteins and organelles in muscle fibers, are just at the beginning to be understood. We have recently found that autophagy-lysosome system is critical to maintain muscle mass and that its alteration leads to muscle atrophy, weakness and to several features that are present in ageing sarcopenia. Thus, dissecting the regulation of autophagy system in skeletal muscle and its role in muscle homeostasis is crucial for developing new therapeutic tools to counteract sarcopenia. This project is an effort in this direction. We aim: i) to identify molecular mechanisms and pathways which are responsible for autophagy regulation in skeletal muscle and which may be targeted to combat age related muscle weakness, (ii) to dissect the cross-talk between muscle and nerve, (iii) to determine the cross-talk between autophagy-lysosome and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Intelligent System Development Platform for Intelligent and Sustainable Society', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The aim of the IMPRESS project is to provide a Systems Development Platform which enables rapid and cost effective development of mixed criticality complex systems involving Internet of Things and Services (IoTS) and at the same time facilitates the interplay with users and external systems. The IMPRESS development platform will be usable for any system intended to embrace a smarter society. The demonstration and evaluation of the IMPRESS platform will focus on energy efficiency systems addressing the reduction of energy usage and CO2 footprint in public buildings, enhancing the intelligence of monitoring and control systems as well as stimulating user energy awareness.The IMPRESS project aims at solving the complexity of system development by providing a holistic approach that includes an Integrated Development Environment (IDE), middleware components, and a deployment tool. The main technical and scientific objectives of the IMPRESS project are: Developing an Integrated Development Environment (IDE) to facilitate Model-Driven Development of Smarter Society Services. Providing a Service-Oriented Middleware to support Mixed Criticality Applications on Resource-Constrained Platforms. Developing easy-to-use and configurable tools for Cloud-based Data Analysis and Context Management. Develop Network and Communication management solution to handle the heterogeneity of Internet of Things. Creating efficient Deployment Tools for Internet of Things applications.The project will be deployed in the Teatro Amazonas Opera House as an attractive showcase to demonstrate the potential of a smart system for reducing energy usage and CO2 footprint in an existing public building.The IMPRESS platform re-uses and extends results from several existing EU projects on Internet of Things
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'York: City of the Past, City of the Future' under Horizon 2020.

assistant: **Concept**

York is an incredibly exciting, vibrant and diverse city, rich in heritage, discovery and an overriding sense of curiosity – in short a city where ideas spring to life and flourish and where collaboration is celebrated. YorNight is symbolic of this collaborative energy with partners across the city involved in promoting a wide range of stimulating events.  Our over-arching objective is to enhance the public recognition of researchers and their work.  YorNight will achieve its objective through the delivery of five key messages:  M1.  Researchers are amongst us  M2.  What’s up with research and innovation?   M3.  Research eases your life and increases your well-being   M4.  Research is fun  M5.  Being researcher is exciting and amazingThese five messages will be central to our Awareness Campaign and our Activities on the Night. YorNight will specifically target young people and seek to influence their perception of researchers and promote scientific careers. The team has received special permission from the UK Scouting and Guiding movement to design a new two-part occasional badge to celebrate European Researchers’ Night. In 2014 and 2015 YorNight will pilot this badge with the aim of expanding the innovation across Europe as part of future Researchers’ Nights, where the Scouting and Guiding movements actively engage an estimated 2.4 million young people.As the UK’s only Heritage and Science city, York is a relevant and unique Researchers’ Night host. The project’s Work Programme will celebrate and explain the depth and breadth of this research across the two years in the theme York: City of the Past, City of the Future. The Work Programme seeks to deliver its key messages through an integrated programme encouraging participants to “Discover and Explore” the research tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Satellite imaging swarms with distributed onboard intelligence'.

assistant: **Innovation**

Space-based monitoring systems for Earth observation are being increasingly employed by industry and governments, and large constellations having tens to hundreds of units will be deployed in the near future. This project considers swarms of satellites in formation flight, and it investigates innovative cooperation modalities to enhance image quality and enable satellite distributed onboard inference. Through artificial intelligence (AI), multiple simultaneous and redundant satellite image acquisitions from different viewing angles will be cooperatively combined into scene representations having significantly higher spatial and spectral resolution and augmented with surface profile information, enabling imaging beyond the diffraction limit by using very high-resolution training sets. These representations will be computed onboard the satellites in a distributed fashion and will be used for inference and image reconstruction; they will allow to increase quality, availability and timeliness of the data and to optimize the usage of inter-satellite and satellite-to-ground communication links. Enabling this cooperation requires major scientific advances; the project will generate new knowledge via innovative scene models allowing spatial/spectral resolution enhancement and 3D augmentation, innovative AI-based compression techniques, novel distributed inference methodologies for AI, as well as a new generation of fast and energy-efficient AI models powering distributed onboard computing. This ambitious research will become the cornerstone of next-generation satellite imaging and inference systems, increasing scientific and economic value for the users and allowing public and private entities to exploit advanced image products and analytics that can benefit the economy and the