RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Magnetic Solid Lipid Nanoparticles as a Multifunctional Platform against Glioblastoma Multiforme' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Central nervous system (CNS) tumors are an important cause of morbidity and mortality worldwide. Among them, glioblastoma multiforme (GBM) is the most aggressive and lethal, characterized by extensive infiltration into the brain parenchyma. Under the standard treatment protocols, GBM patients can expect a median survival of 14.6 months, while less than 5% of patients live longer than 5 years. This poor prognosis is due to several factors, including the highly aggressive and infiltrative nature of GBM, resulting in incomplete resection, and the limited delivery of therapeutics across the blood-brain-barrier (BBB).The present project aims at addressing these therapeutic challenges by proposing a nanotechnology-based approach for the treatment of GBM, focused on the selective uptake of drug-loaded multifunctional magnetic solid lipid nanoparticles (SLNs). An external magnetic guidance will help the SLN accumulation on the cerebral endothelium, where, owing to their lipid nature, they will be allowed to enter the CNS. Here, appropriate surface ligands will drive their internalization inside cancer cells. The chemotherapeutic payload will undergo release, allowing a targeted pharmaceutical treatment that will be combined to hyperthermia upon appropriate radiofrequency application. A synergic attack against GBM will thus be performed, consisting of a chemical attack thanks to the drug, and a physical attack thanks to hyperthermia, that will dramatically enhance the possibilities of therapeutic success.By demonstrating the effectiveness of the platform to cross the BBB and to support tumor regression, a huge impact on human healthcare is envisioned. Moreover, further outcomes of this project are expected by considering the development of nanotechnology-based, multi-functional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Generic Evaluation Platform for Services Interoperability and Networks', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

IASON project aims to design and develop a novel, flexible and highly efficient system capable of operating as a uniform evaluation platform, able to measure the performance of networks of diverse technology, such as, ISDN, SS7, ATM, GPRS, 3G UMTS, IP as well as the services provision and any type of inter-operability among them. The IASON evaluation platform will make it possible to bridge the gap in evaluation systems by providing the ability to measure the performance of heterogeneous network technologies (i.e. GPRS, 3G UMTS and ATM, ISDN) and offer the ability to measure the quality of services over diverse network technologies. The IASON solution will exhibit an open architecture that is meant to be fully flexible, as it will be a single system able to connect to a wide range of telecommunication networksObjectives:To design, develop and integrate the hardware and software sub-systems for providing the modular and generic architecture that is required to enable the evaluation procedures of heterogeneous networks, services and applications.To design and adopt the evaluation methodology of network traffics in terms of generic measurements set that best represent the quality of protocol, services and real users applications operation.To identify and deliver the required protocol stacks (3G and 2G UMTS, GPRS, GSM, ATM and N-ISDN) functionality so that to enable the extensive evaluation of networks based on existing sub-systems from partners, on both signalling and user plane communication sections.To validate IASON system's ability to assess networks and services performance by setting up a trials environment on the 3G UMTS platform of Siemens and Alcatel.Work description:The project is organised in six (6) workpackages bringing the necessary partners and ingredients f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'SELF-INSTALLING TELESCOPIC SUBSTRUCTURE FOR LOW-COST CRANELESS INSTALLATION OF COMPLETE OFFSHORE WIND TURBINES. DEEP OFFSHORE 5MW PROTOTYPE'.

assistant: **Innovation**

In ELICAN, a strong team of complementary European companies with worldwide leading presence in the Wind Energy industry join forces to provide the market with a disruptive high-capacity and cost-reducing integrated substructure system for deep offshore wind energy. The technology is exceptionally fitted to meet the technical and logistical challenges of the sector as it moves into deeper locations with larger turbines, while allowing for drastic cost reduction. This project will design, build, certify and fully demonstrate in operative environment a deep water substructure prototype supporting Adwen’s 5MW offshore wind turbine, the be installed in the Southeast coast of Las Palmas (Canary Islands). It will become the first bottom-fixed offshore wind turbine in all of Southern Europe and the first one worldwide to be installed with no need of heavy-lift vessels. The revolutionary substructure consists in an integrated self-installing precast concrete telescopic tower and foundation that will allow for crane-free offshore installation of the complete substructure and wind turbine, thus overcoming the constraints imposed by the dependence on heavy-lift vessels. It will allow for a full inshore preassembly of the complete system, which is key to generate a highly industrialized low-cost manufacturing process with fast production rates and optimized risk control. The main benefits to be provided by this ground-breaking technology are: •  Significant cost reduction (>35%) compared with current solutions. • Direct scalability in terms of turbine size, water depth, infrastructure and installation means. • Complete independence of heavy-lift vessels • Excellently suited for fast industrialized construction. • Robust and durable concrete substructure for reduced OPEX costs and i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Reducing myopia progression with red light therapy: Treatment mechanisms and safety levels.'.

assistant: **Concept**

Myopia (shortsightedness) represents a mismatch between the eyes length and its dioptric system (refracting power), which results in distant fixated objects being imaged in front of the retina. The underlying problem is typically excessive eye elongation, multiplying the risk of sight-threatening eye diseases. Faced with rapidly increasing myopia prevalence figures worldwide, and associated huge economic burdens, public health systems need more and improved myopia control in children. A recently described, controversial method for reducing myopia progression in children is low-level red-light therapy (LRL), with clinical trials reporting significant effects with daily, short periods of direct retinal red laser light stimulation. However, a recent report of retinal damage and reduced vision, along with inadequate safety monitoring calls its safety into question. MyReL addresses open questions regarding the underlying mechanism, ocular effects, risks and long-term safety of LRL using an established animal (guinea pig) model of myopia and complimentary studies in humans. The interdisciplinary project will allow detailed evaluation of LRL-induced structural and functional changes in myopic guinea pig eyes. Results from the latter will be used to inform a complimentary human study focused on 3 areas, in which choroidal thickness will serve as a biomarker for therapeutic effects: (1) the intensity-dependent dose-response effects of LRL (limited to established safe intensities), (2) short-term effects of ambient red-light exposure, (3) effects of manipulating the spectrum of digital device screens. Plausible outcomes of these novel studies include a prototype for hazard-free LRL, as well as recommendations on optimal spectral settings for digital devices, both aimed at control
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Manufacturing Visions - Integrating Diverse Perspectives into Pan-European Foresight' (MANVIS).

assistant: **Concept**

An informed view of the possible futures for manufacturing industries is essential as input for policy-making and industrial strategies while aiming at the Lisbon goals. In order to reach these objectives, multiple actors have to discuss their visions, val ues and expectations on the future of manufacturing establishing a knowledge community on trends, visions and alternatives in manufacturing, product and service engineering. As a tool, a pan-European Delphi expert survey will be launched in 22 states (EU-M S, ACC, EUREKA). It will cover developments in all relevant aspects of manufacturing, from technologies via organisational concerns to questions of the working environment and sustainability. Enabling technologies for developments in all these areas will b e identified. Arising demands on skills and competencies will also be derived from the results. In addition, a group of international experts from all continents will be involved in the statement generation. Another activity collects the views of users, co nsumers and other societal groups concerned with manufacturing. Scientists from eight European research institutes, all of them well experienced in foresight and national partners from another 14 European countries will ensure the results. These will be co nsolidated in a web-based database, comprising the views of approx. 3,000 experts and allowing national subsamples. The reports will provide policy recommendations for the Commission (mid-term reviews, Manufacturing Action Plan) and at national or EUREKA l evel.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for '(EU) Explorations in Next Generation Internet emerging research opportunities, technOlogies and methods.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

No other technology has been able to radically reshape and permeate the very fabrics of our societies as rapidly and fundamentally as the internet has. But the increased concentration of power on the internet in the hands of just a few ever more dominant players makes that few now reap the true benefits of the digital economy; the growing complexity and opacity of the processes and technologies that govern it makes challenging this status quo exceedingly difficult.  Serious interventions are needed to make the next generation internet inclusive, resilient and competitive again. By intervening in the development process of emerging technologies, we are able to steer the process of innovation in a human-centric and ethical direction and allow European businesses and civil society organisations to play a leading and pioneering role in their development.  But to help direct and shape the future internet, we need to know which technologies will underpin it. To identify the technologies that will likely be game changers for the internet in 2025, we use cutting edge big data methodologies and novel web-scraped data sources to capture early signals about technologies and research topics, and develop a rigorous process for evaluating whether a technology will positively contribute to the development of a more desirable internet.  The EU Engineroom project approach is centred around the articulation of an ambitious and concrete vision for the future internet, and the development of a methodology for identifying those technologies and research topics that will underpin that vision of a more inclusive, resilient and competitive internet by 2025. This methodology will form a key pillar for future phases of the NGI initiative as an easily-reproducible and comprehensive tool for conti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Climate relevant interactions and feedbacks: the key role of sea ice and snow in the polar and global climate system'.

assistant: **Objectives**

Sea ice is an integral, changing part of the global Earth system. The polar climate system affects lives and livelihoods across the world by regulating climate and weather; providing ecosystem services; and regulating the ability of humans to operate (hunting, shipping, and resource extraction). CRiceS improves understanding of how rapid sea ice decline is interlinked with physical and chemical changes in the polar oceans and atmosphere. In order to plan for and adapt to polar and global climate change, CRiceS aims to fully understand the causes and consequences of this polar transition. Climate and Earth System Models (ESMs) are the key tools for projecting climate change in order to mitigate the impacts and to adapt. However, these models have major shortcomings in their descriptions of interconnected polar ocean-ice/snow-atmosphere interactions that limit their ability to project teleconnections, feedbacks, and impacts. CRiceS will quantify the controlling chemical, biogeochemical, and physical processes/interactions within the coupled ocean-ice/snow-atmosphere system through comprehensive analysis of new and emerging in-situ and satellite observations. CRiceS improves process, regional, and climate models/ESMs by advancing descriptions of (1) sea ice dynamics/energy exchange, (2) aerosols, clouds and radiation, (3) biogeochemical cycles/greenhouse gas exchanges and (4) fully coupled system behavior. This improved understanding allows for assessment of the role of ocean-ice/snow-atmosphere interactions in polar and global climate and delivers improved quantification of feedback mechanisms and teleconnections within the Earth system. Improved future projections and multi-sectoral impact assessments will increase our capacity to mitigate and adapt to climate and enviro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Enhancement of mesenchymal stem cell therapy for graft versus host disease' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Steroid resistant acute Graft versus Host Disease (GvHD) is a very serious complicationassociated with allogeneic haematopoietic stem cell transplantation. There is no established consensus on the therapy for this disease and the prognosis for these patients is poor. Early reports of MSC therapy for acute GvHD involving small numbers of patients were promising, however, results from large scale multi-centre phase III trials have questioned the therapeutic efficacy of MSC therapy for GvHD. Our hypothesis is that MSC require licensing for therapeutic efficacy in GvHD. This project addresses a number of very important and clinically relevant questions; Why are IFN-gamma licensed MSC more efficacious in the treatment of acute GvHD in pre-clinical models? What are the differences between licensed and unlicensed MSC that facilitates the enhanced efficacy? The final element that this project will address is whether or not correlates of MSC therapeutic efficacy can be identified and translated into the clinic. This research is both internationally competitive and innovative in that no correlates have been identified for MSC therapeutic efficacy and the provision of such information would transform the field of MSC therapy for the treatment of GvHD.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Innovative adhesives for ear drum healing'.

assistant: **Innovation**

The ERC ADG “Engineering of biomimetic surfaces – Switchable micropatterns for controlled adhesion and touch” (SWITCH2STICK) has developed micropatterned polymer surfaces for innovative adhesive functions without glues, based on the “gecko adhesion principle”. While robotic applications were originally in the focus of these developments, a radically new application field of these microstructures will be taken to the initial steps of application and subsequent commercialization: the repair of injuries of the human tympanic membrane. Tympanic membrane damage is a frequent medical affliction, affecting over 30 million patients worldwide each year. It results in hearing loss, associated with a dramatic impact of the patients’ quality of life and a significant healthcare burden. Our invention suggests a new therapeutic option to replace conventional therapies: Wound management with a novel gecko-inspired surface structure. In collaboration with clinicians, the feasibility of the new technology has been demonstrated. When designed for interaction with skin, our surfaces cling reliably to mouse ear drums for up to 28 days. In addition to the adhesive function, they provide support for cell growth and proliferation and allow the option of local drug delivery due to the micropattern. Besides detailed market analyses and dissemination, activities in the proposed project range from a technical and pre-clinical validation in an animal model to establishing an IPR strategy and an initiation of the medical product certification. Our invention will overcome several critical limitations of existing solutions. Besides ear-drum repair, the project enables a wide field of additional medical applications ranging from electrode fixation to the fitting of wearable healthcare electronics. Thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Joining Efforts for Responsible Research and Innovation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The goal of the project is to foster RRI transition in Europe by developing and testing good RRI practices in pilot cases, for a further upscaling among the RTOs in the EU28. A Responsible Research and Innovation (RRI) Plan will be developed and implemented at the biggest European RTOs, the Fraunhofer-Gesellschaft and TNO, covering the five RRI key dimensions (societal engagement, gender equality and gender in research and innovation con-tent, open access, science education and ethics). After identifying the state-of-the-art of good RRI practices, goals will be developed for within each dimension. Barriers for the achievement of these goals will be analyzed, and an action plan to overcome these barriers will be formulated. The project will be set up as a mutual learning process between the consortium, further European RTOs, stakeholders, and two international associated partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrated services aimed at dual diagnosis and optimal recovery from addiction (ISADORA)' (ISADORA).

assistant: **Concept**

This prospective multicoated study is designed to describe service provision for patients with dual diagnosis in seven European psychiatric settings and to compare morbidity and service use for these patients with morbidity and use for patients with single diagnosis over a period of 12 months. The pattern and distribution of severe psychiatric illness and addiction will be described in each sample. The study will examine risk factors for subgroups in the samples with a specific focus on gender. The outcomes studied will comprise severity of addiction, psychiatric symptoms, treatment compliance, psychosocial functioning, social network, relapse and mortality and will be compared with a control group. Views of clients and staff concerning the adequacy of service provision will be explored. On the basis of these analyses, an educational programme for the staff of the participating centres will be developed and disseminated on a European basis.