RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'TRIAD: Enhancing Synergism on Telomere Function in Health and Disease' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Over the years, the EU investments, i.e., ERDF and RRF, have played a crucial role in advancing biomedical research in underperforming EU Member States. However, in competitive research fields, ERDF/RRF-funded labs face significant challenges, including mismatches between regional and European approaches, disparities between Horizon thematic priorities and national/regional smart specialization strategies, as well as variations in funding allocation between consortia and single beneficiaries. The absence of coherent internationalization strategies, limited training programs and skilled personnel, fragmented research endeavors, and funding constraints further hinder the development of sustainable research synergies with leading research institutes. To address this pressing need, we propose TRIAD, a program utilizing the upstream synergy model under pathway A to enhance collaboration among three ERDF-funded labs in Greece, Portugal, and the Czech Republic with a scientific focus on the functional role of telomeres in health and disease. Leveraging ERDF funding, the three research teams have developed complementary expertise in research tools, platforms, and approaches at a regional level. The core objective of TRIAD is to enable the individual ERDF beneficiaries to overcome isolation through cross-border collaboration and successful participation in Horizon Europe calls. This will be achieved through a comprehensive collaborative strategy to share methodologies, an extensive human resources development plan, a set of activities to enhance innovation capacity and improve access to European R&I networks, as well as to increase competitiveness in research funding, and establish effective management and administrative structures on site. We anticipate that this strategy will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Regional Acceleration for the INnovation circle in the ICT Sector' (RAIN) targeting Sixth Framework.

assistant: **Abstract**

The project aims at increasing innovation and competitiveness in European industry by means of harmonising the activities of regional, national and international research initiatives. It will significantly contribute to creating enhanced circumstances for attracting increased regional investment into ICT sector RTD, and consequently more streamlined means for ICT innovations to reach full their market potential.The project will involve regional innovation organisations, research and industry actors, many of which are from New Member States. Regional circumstances will be scrutinised and success rates of prior and existing regional RTD investment policies will be benchmarked. As the main deliverable, the project will create a set of guidelines for best-practice RTDI policy-making under diverse regional conditions.During the project, public or publicly owned companies will join the forces with local, regional and national bodies and universities in shaping innovation policy. The consortium comprises expertise and knowledge contributed by a balanced combination of RTDI policy-makers and stakeholders that implement the policy.Project activities will include systematic gathering, exchange and analysing of knowledge on a regional and national levels and elaborate d in selected cases in some of the regions, regarding the current structure of RTD investment into the ICT sector. Based on the benchmarked information and experiences set forth by consortium participants, the aforementioned set of RTDI guidelines will be composed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Chemical Rewiring of Oncogenic Transcription' under Horizon Europe.

assistant: **Concept**

Many cancers are driven by mutations affecting transcription regulation. Through cancer genome sequencing studies, we understand that these aberrations are pervasive through many layers of gene control. Yet, with few exceptions, this knowledge has not precipitated in effective treatments since pharmacologic inhibition of transcription is often infeasible or functionally inconsequential.To address this limitation, I want to innovate chemical strategies that move beyond loss of function (LOF) approaches. Gene control is organized at the level of proximity. Hence, I hypothesize that transcriptional regulators can be chemically rewired by neomorphic small molecules that recruit functionally opposing gene-regulatory effectors, thereby prompting an acute, deep, and sustained disruption of oncogenic transcriptional circuits. The identification, characterization, and translation of such Neomorphic Transcriptional Compounds (NeoTraCs) will be the subject of the GE|NEomorph proposal. We will focus on NeoTraCs to rewire the repressive PRC2 complex, the p400 chromatin regulator complex, and the non-canonical BAF complex. While these targets have established roles in various cancers, inhibitors are not available or have limited functional impact.To identify NeoTraCs that address these limitations, we will implement a diverse discovery approach that incorporates hypothesis-driven design with phenotypic strategies geared to co-opt undrugged transcriptional effectors via bivalent NeoTraCs, and unligandable effectors via molecular glue-like NeoTraCs. Identified hits will be characterized via multi-omics approaches. Through careful mechanistic investigation, we will deduce general mechanistic principles, understand their impact on oncogenic transcription and investigate associated transl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Skill-based Propagation of ""Plug&Produce""-Devices in Reconfigurable Production Systems by AML""' (SKILLPRO) targeting Seventh Framework.

assistant: **Abstract**

It is increasingly evident that the era of mass production is being replaced by the era of market niches. The key to creating products that can meet the demands of a diversified customer base is a short development cycle yielding low cost, high quality goods in sufficient quantity to meet demand. This makes flexibility an increasingly important attribute to manufacturing.In response the reconfigurable manufacturing system (RMS) concept has emerged in the last few years as an attempt to achieve the required manufacturing flexibility. A RMS proposes a manufacturing system where machine components, machines, cells, or material handling units can be added, removed, modified, or interchanged as needed to respond quickly to changing requirements. Compared to flexible manufacturing systems (FMS), this approach is believed to have the potential to offer a cheaper solution, in the long run [...] as it can increase the life and utility of a manufacturing system.A lot of research has been conducted towards establishing such a production system, the most prominent of those approaches being the ""Plug&Produce"" paradigm - in analogy to the ""Plug&Play"" paradigm of the Computer Industry. 'Plug-and-Produce' allows the automatic configuration and seamless integration of heterogeneous devices into a system.However, while the ""Plug&Produce"" paradigm has contributed greatly towards reducing commissioning effort and ramp-up time for new components, it has been too focussed on solving interoperability issues by means of standardized interfaces and service or agent-oriented ICT-architectures.Enhancing these approaches by taking into account the knowledge about the capabilities/skills of the new devices and their impact on the overall capabilities/skills of the production system in terms o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Biology of Type IV Secretion Processes'.

assistant: **Objectives**

Top 6,5 et bas a 18 cm Discoveries in recent years revealed that microbial type IV secretion systems play a key role in many medically and ecologically relevant processes. Transfer of virulence factors from pathogenic bacteria to humans and the spread of disease resistance determinants are being studied by researchers from academia as well as industry. The proposed meeting series will give European researchers with different scientific backgrounds (medical, biochemical and ecological) the opportunity to exchange ideas and advance their understanding of type IV secretion. Knowledge has been rapidly increasing since the common mechanism of type IV secretion was suggested about six years ago. Goal of the first meeting will be to collect insights on the Medical and Ecological Implications in different experimental systems. Sessions will mainly deal with different basic aspects of type IV secretion systems, such as substrate metabolism, transfer mechanism, host response and ecological implications.The scientific exchange will help to devise strategies for industrial applications, such as the isolation of inhibitors for type IV secretion-mediated transfer of virulence factors, which will be assessed in roundtable discussions. Goal of the meeting series is to foster basic as well as applied aspects of research on type IV secretion. Therefore, the second meeting on Mechanisms and Applications in Biotechnology will focus on the advances derived from basic studies on the secretion mechanism and their exploitation in biotechnology. Genomic studies on pathogenic microbes proved to be especially revealing in the past, and a special session will address recent developments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'innovative ICE Protection And Shielding System for HLFC Demonstrator' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Aircraft manufacturers are continuously seeking for decreasing their CO2 emissions and trying to make flights more efficient and eco friendly. As part of this searching one major warhorse is the drag reduction during flight; One of this systems is the Laminar Flow Control LFC, where Hybrid Laminar Flow Control (HLFC) is included. Classic systems as IPS and shielding systems have to coexist with the new HLFC system in a much reduced allocation space. Towards the new generation of more efficient aircraft the use of More Electric Aircraft (MEA) is increasing during the recent years and modern aircrafts such as Airbus A350 and especially Boeing 787 are mounting more electrical systems.This project faces two challenges. Firstly to develop an electrical harness for power feed and monitoring systems of the HLFC, and secondly to develop an innovative way of carrying electricity in an aircraft to solve the big problem of lack of space in the leading edge where these HLFC systems operate. Regarding the first challenge IcePass proposal includes a detailed study of the new routings, with selection of components, and application of additive manufacturing tecnologies for brackets, in order to fullfill the complex space requirements of HLFC. For the second challenge  IcePass proposes an innovative flat harness concept with application of 3d printing technology which will solve the space problem in the L/E and make possible an HLFC system. Whatismore, IcePass proposes aswell an innovative way of routing harnesses through mechanisms, and particularly for the actuation system, by application of slip rings.Solving both challenges, IcePass will manage to design and manufacture the electrical system of the HLFC thanks to the application of innovative wiring system concept which will change
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Microcalorimeter Type EDX System Assessment', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

CSP has developed a high resolution, superconducting EDX spectrometer as well as a mechanical, low temperature cooling system. The detector reaches an approximately ten times better energy resolution than conventional EDX. The cooling system allows reaching temperatures of 40mK, its operation is vibration free and can be completely automated. These features and the complete fluid gas free cooling system allow applications on SEMs in cleanroom environments, e.g. on Defect Review Stations. The superior performance makes the detector most suitable for small structure and particle analysis required in IC industry when feature sizes are shrinking as well as for light element analyses. That detector type has an enormous future potential. A participation in the assessment program would support an European equipment manufacturer to take a leading role in an emerging technology and would contribute to the creation of new high tech jobs.Objectives:Objectives are to demonstrate the equipment's capability to perform in a long term reliably in an industrial environment and to evaluate its enhanced capabilities for 0.18/0.15 µm applications and interconnect technology. Due to a superior performance compared to state of the art, the system will offer new solutions in surface analysis. Thus, it will be an issue to demonstrate how the system may contribute to shorter process development times and make quality control more efficient. The natural place for the system is failure analysis labs. Since currently small surface feature sizes are analysed with expensive and time intensive methods, it is an objective to evaluate the cost savings when microcalorimeter EDX is employed as well as other parameters related to economy, reliability, user friendliness and equipment effectiveness. It is a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of glioblastoma and blood-tumour barrier models for investigating the combination therapy of anticancer agents and efflux pump inhibitors' to be submitted under Horizon Europe.

assistant: **Abstract**

Glioblastoma (GBM) remains the most common malignant primary brain tumour with a median survival <2 years. One of the reasons for the failure of GBM therapy involves limited drug access to the tumour site due to the presence of the blood-brain barrier (BBB)/blood-tumour barrier (BTB). Although these barriers differ, they share some common features, such as tight junction (TJ) and efflux proteins of the ATP-binding (ABC) cassette superfamily that regulate drug access to the brain parenchyma. Similarly, efflux proteins have been identified in GBM that form an additional barrier. In the proposed research, five-dimensional (5D) models of GBM-BTB will take into account all characteristics essential to approach more realistic in vivo conditions, mainly the integration of glioblastoma stem cell (GSC) derived pericytes into BTB, and the incorporation of varying degrees of tumour cell differentiation (from GCS to well differentiated cells) showing a different degree of intrinsic chemoresistance. Additionally, microfluidic models reproducing blood flow will add a temporal and dynamic dimension (""5D models""). Once the models are established and compared with static ones, the effect of anticancer therapy and efflux protein inhibitors (EPIs) will be verified in terms of TJ and ABC protein expression using qRT-PCR and confocal microscopy. The identified combination therapy of anticancer agents and EPIs will lead to validation in patient-derived GMB-BTB models with different molecular profiles and degrees of resistance, with the goal of personalised medicine. By working on this project, the researcher will gain valuable experience that is needed to address the challenges associated with the treatment of therapy-resistant tumours. In general, this project may provide a more realistic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Skin-Based Technologies and Capabilities for \nSafe, Autonomous and Interactive Robots'.

assistant: **Innovation**

This project will develop and demonstrate a range of new robot capabilities based on robot skin tactile feedback from large areas of the robot body. An investigation of these issues until now has been limited by the lack of tactile sensing technologies enabling large scale experimental activities, since so far skin technologies and embedded tactile sensors have been mostly demonstrated only at prototype stage. The new capabilities will improve the ability of robots to operate effectively and safely in unconstrained environments and also their ability to communicate and co-operate with each other and with humans. To support this aim, one part of the project will focus on the investigation of methods and technologies enabling the implementation of skin sensors that can be used with existing robots. Other parts of the project will develop new structures for representing and integrating tactile data with existing cognitive architectures in order to support skin-based cognition, behaviour and communication. As a result, the project will address three main objectives. The first is to develop new sensor technologies that can provide tactile feedback from large areas of the robot body. This development process will be incremental and will take advantage of feedback produced from the application of these technologies in the work done on the other project objectives. The second objective is to develop and integrate fundamental cognitive structures for efficient and safe utilisation of tactile data in terms of a robot body image, safe reflexive reactions to tactile events and flexible representations of spatially and temporally distributed patterns of physical contact. The last objective is to develop cognitive mechanisms that use tactile feedback to improve human-robot interactio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ion channels from viruses - simulation and conductance study 6' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content lon channels encoded by viruses are a relatively unexplored class of integral membrane protein which present potential targets for novel drugs. Channels formed by assemblies of the transmembrane (TM) alpha-helices of the M2 protein from influenza A and from the Vpu protein of HIV-1 will be explored. Computer simulations will be applied to:- (i) interactions of viral channel TM helices with lipid bilayers; and (ii) conductance properties of the resultant channels. Measurements of ionic currents across planar lipid bilayers will define the properties of ion channels formed by synthetic TM peptides. Simulation and experimental studies will focus on:- (i) effects of pH (M2) and ionic concentration (Vpu) on channel formation and stability; and (ii) conductance of protons (M2) and of cations vs. anions (Vpu). The project will provide basic physico-chemical characterisation of viral ion channels for future spectroscopic investigations and for design of novel anti-viral drugs. Training content (objective, benefit and expected impact) The overall objective is to investigate structure/function relationships of integral membrane proteins. Techniques of simulation, conductance measurements and peptide synthesis are necessary to complement data from other ion channels by FTIR spectroscopy. Links with industry / industrial relevance (22) The combination of computational and experimental studies of viral ion channels opens up possibilities of drug development and screening.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'High peak power xuv radiation sources based on high order harmonic generation - optimization, characterization and application to xuv multiphoton processes' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The advent of table-top-terawatt lasers has opened the pos- sibility of realizing XUV radiation sources based on extre- mely high order harmonic generation. Some unique features of such radiation are: coherence, short pulse duration, small divergence and tunability. Several aspects of the har- monic generation process are still under study in order to determine experimental conditions that maximize the XUV pho- ton flux. The final goal is to obtain XUV radiation intensi- ties above 1012 W/cm2 which will open a new branch of Ato- mic Physics, namely multiphoton processes with XUV radia- tion. To this end, the applicant will focus his work on harmonic generation optimization, on guiding and focusing of XUV radiation and on some specific application in XUV multiphoton processes.