RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Lanthanides as electron Dimmer switch in organometallic catalysis'.

assistant: **Objectives**

Complexes containing redox non-innocent ligands have been well developed in the last decade with transition metal ions and have led to very important chemical transformations at lowest environmental and economic costs. Nonetheless examples with f-element are very rare and the field is almost empty with lanthanides. This is unfortunate since divalent lanthanides are excellent sources of single electron and would provide a good control of the ligand reduction because of strong electron correlation in these systems. Thus, this proposal aims at developing this field with organolanthanides. The synthesis of original complexes containing lanthanides, redox non-innocent ligands and transitions metals is herein proposed: the first providing reversible electron(s) source(s) (remote control), the second acting as electron(s) reservoir and controlling the electron correlation strength (“dimmer switch”), and the last being the site of the selective catalytic reaction. Because of this regulated electron transfer, the oxidation state of the transition metal will be modified only at specific steps, allowing the establishment of a new paradigm is organometallic catalysis with group 9 and 10 transition metals. These original complexes will be synthetized and deeply characterized by specific spectroscopic and theoretical analyses. The principal goal is to synthetize active catalysts toward C-H bonds activation, and methane activation is regarded as an ultimate achievement as is hydroalkylation of olefins. To increase the chances of success, the proposal is based on preliminary results obtained recently in the group. Several examples of original heterobimetallic and heterotrimetallic complexes containing lanthanides and transition metals of group 10 will be discussed as a good starting po
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'UPright radiotherapy: Learning, Innovation, Fellowship and Training' (UPLIFT).

assistant: **Innovation**

Radiotherapy (RT) is a mainstay of modern cancer treatment. Conventionally, RT is delivered to the patient lying on a treatment couch, while a beam steering device (gantry) aims the radiation from any angle around the target. Positioning the patients in upright body posture (upRT) instead enables to orient the patient arbitrarily toward a fixed beam. This enables smaller facility footprint and reduced treatment cost, placing upRT in the core of the UN sustainable development goals, and opening global access to advanced treatment options: 80% of cancer patients live in countries which host only 5% of the worlds RT resources. Moreover, upRT improves patient comfort and is associated with anatomical and physiological advantages, such as reduced breathing motion. It therefore comes as no surprise that, with new upright patient positioning & imaging solutions entering the market, upRT is enjoying a surge in interest. Yet, key scientific questions remain, international guidelines for upRT are lacking, and existing RT workflows are geared to lying patients. As the first clinics adopt new upRT technologies, there is a global need for trained professionals in industry, clinics and academia, to reach the promised benefits for patient care. UPLIFT builds this next generation of experts by addressing key research questions related to: treatment planning, clinical workflow and equipment design. Leveraging latest upRT technology available through our world-class consortium, UPLIFT propels Europe to the forefront of the upRT paradigm shift. UPLIFT focuses on: Learning (through its academic and clinical centres of excellence); Innovation (through its leading industrial partners); Fellowship & Training (through an outstanding cross-sector programme of workshops, secondments & mentoring)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Artificial Intelligence and IoT for seismic monitoring' (Quakebots).

assistant: **Concept**

The objective of the Quakebots project is to introduce and validate a novel technology and tools for disaster management during earthquakes, with the ambition of minimizing both direct and indirect damage during and after a seismic event, increasing people safety and helping in the assessment of post-seismic damage to critical infrastructures.Recent news of disasters in central Italy, and southern Europe in general, demonstrated how earthquakes are one of the most harmful natural disasters, accountable for invaluable losses in terms of damage to critical infrastructures, cultural heritage and impairment of local transportation and energy distribution network. Unfortunately, the countries that are more exposed to seismic risk show also the highest percentage of building heritage older than 40 years, more than 75%, and ancient historical buildings, with no seismic aware design in place. In such countries, earthquakes are also accountable for countless death tolls.Quake Engineering proposes a distributed sensor network that is capable of automatically detect the occurrence of primary waves during a seismic event, and acting as a distributed IoT P2P neural network, propagate an alert to all the other nodes in the network in cascade. This “signaling” wave propagates much faster than the harmful secondary waves, providing the users with a local acoustic and visual alert, giving them a small time frame in the magnitude of tens of seconds for taking safety critical actions.The main purpose of the project is to carry an extensive demonstration of the effectiveness of the solution in a medium scale scenario, targeting the B2B and B2A markets as the most promising and eager early adopters. The project will also cover the incremental research and development effort for a rapid mark
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Membrane-Free Redox Flow Batteries' (MFreeB) under Horizon 2020.

assistant: **Objectives**

The environmental concerns over the use of fossil fuels have promoted great interest in generating electric energy from renewable sources such as solar and wind. However, the intermittent nature of those resources demands high performing and cost-effective energy storage systems. Redox Flow Batteries (RFBs) present several advantages, namely, total decoupling of power and energy densities and the possibility of rapid mechanical charging by substituting spent electrolytes with fresh ones. The major issues of the current Vanadium RFBs are the high price and toxicity of vanadium components and the high cost and low performance of the ion-selective membranes they require. MFreeB project proposes to completely remove the problematic membrane of RFBs by developing a disruptive, versatile and scalable concept of Membrane-Free RFB implementing efficient catholytes and anolytes in which the metallic redox pairs are replaced by cheap, abundant and environmental-friendly molecules. In order to achieve this objective, I propose a multi- and interdisciplinary research methodology across a wide range of expertise including fundamental electrochemistry, thermodynamics, physical chemistry, modelling, and mechanical engineering. I will make use of advantages of different electrolytes to develop a versatile concept of Membrane-Free RFB with a wide range of applications.This Consolidator Grant (ERC) would provide adequate support to consolidate my own independent research team and programme. During my scientific career, I have demonstrated creative thinking and excellent capacity to carry out research going beyond the state of the art. My meritorious record of scientific publications (55 ISI articles, h index = 25), project leadership, international collaborations and capacity for supervi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ultrafast phenomena in nanoparticle excitations' in the context of a Seventh Framework call.

assistant: **Objectives**

The proposed research aims at the investigation of ultrafast nanoparticle excitations, especially in the sub-10-fs domain. To this end, state-of-the-art controlled optical waveforms will be used with pulse durations comparable to the oscillation cycle of light. These sources have been enabling breakthrough achievements in ultrafast science in recent years and the extension of their use in nanoplasmonics also promises novel results. I plan to investigate ultrafast, coupled propagating and localized plasmonic modes via spatially and spectrally resolved photoelectron emission from the nanostructured metal sample as well as scaling effects with femtosecond sources having different wavelengths (800 nm and 1800 nm). Ultrafast photoemission from closely spaced, coupled nanoparticle pairs will also be investigated. With these setups, both quantum and classical effects can be investigated on the photoemitted electrons. These experiments will be enabled by state-of-the-art femtosecond sources, high-resolution electron spectrometers and nanofabrication methods available at the host institute. These will be ideally complemented with my know-how of the applicant in femtosecond technology and ultrafast photoemission experiments. The extension of this know-how towards nanoscience is an expected benefit as a result of the research stay.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Making I-CNS A Reality'.

assistant: **Objectives**

In recent years a lot of attention has gone into the concept of integrating Communication, Navigation, and Surveillance (CNS) services.  While no clear criteria exist for what exactly constitutes “integrated” CNS, a common interpretation is that a single radio technology will serve multiple purposes, potentially covering all three domains.  This perspective is most attractive in the sense of spectrum efficiency, as each radio link will serve multiple domains simultaneously, instead of a single one.  In addition to the multi-domain utility of L-band digital aeronautical communication system (LDACS), MIAR will also implement various Positioning, Navigation and Timing (PNT) technologies to concurrently provide a modular approach to navigation.The project aims to demonstrate that LDACS can support CNS services on an aircraft.  The proposal is centered around flight experiments, which will use LDACS-based CNS services to provide optimized separation between aircraft in real time, thus making optimal use of the airspace while being spectrum efficient.In addition to multi-domain use of one technology, MIAR will also feature the ability to support NAV services from multiple, modularly interchangeable technologies.  This aspect will be an important piece to the standardization of “Modular APNT”.A real-time, in-flight demonstration of separation controls will be the first of its kind using a single physical layer: LDACS.  This fact, combined with the ambition of bringing all components to TRL-6, is a show of the potential for LDACS and other new technologies to support the future of aviation.MIAR will cover two crucial developments, which will be world-first: use of LDACS for integrated CNS and the use of multiple non-GNSS technologies to provide an integrated navigation solution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'ER Stress and Photoreceptor Degeneration in Drosophila' to be submitted under Seventh Framework.

assistant: **Abstract**

The endoplasmic reticulum (ER) is the cell organelle where secretory and membrane proteins are synthesized and folded. The presence of unfolded/misfolded proteins in the ER causes stress to the cell (“ER stress”) and activates the Unfolded Protein Response (UPR), a cellular response to restore homeostasis in the ER. The presence of misfolded proteins and activation of the UPR have been connected with many diseases and pathological conditions. My goal is to elucidate the molecular mechanisms that regulate neuronal degeneration and cell death induced by ER strees, using Drosophila melanogaster as a model system. To achieve this goal, I propose the following specific aims: 1. Analysis of the molecular mechanisms required for induction of cell death in the context of ER stress. 2. The mechanism of induction of cell death by Xbp1spliced 3. Developmental role of the UPR during photoreceptor differentiation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Role of TAM signaling in Retinal Homeostasis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Macular and retinal degeneration are common blinding conditions which affect approximately 30% of individuals aged 75 years, and pose considerable socioeconomic burden. Lack of the daily phagocytosis of photoreceptor outer segments (POS) by Retinal Pigment Epithelium (RPE) cells is the basis of such retinal degeneration (RD). This proposal aims to characterize the role of TAM receptor Tyrosine Kinase signaling in maintaining healthy retinal homeostasis. TAM receptors (Tyro3, Axl, Mer) are homeostatic regulators of the Immune, Reproductive and Nervous systems. Mer knockout mice show normal retinal structure at birth; however, at three weeks of age photoreceptors (PRs) begin to undergo apoptotic death, and by 8 weeks the entire PR population is eliminated, causing blindness. Mer mutations in rats and humans, leads to impaired vision and blindness. The two TAM ligands ProS and Gas6 are expressed in the eye. In-vitro experiments have identified Gas6 as the relevant ligand necessary to activate PR phagocytosis, but adult Gas6 KO mice have no PR degeneration, suggesting a role for ProS. To investigate whether ProS is a TAM agonist leading to PR phagocytosis, I developed a unique ProS conditional knockout mouse model. Preliminary results indicate that mice lacking ProS in the eyes show mild RD, suggesting ProS is a functional ligand in-vivo. Deleting both ligands causes severe RD, implying synergism between both ligands. This novel evidence illuminates the mechanism of TAM signaling in-vivo suggesting ligand hetero-dimerization. Using the newly generated mouse model, I propose to characterize the detailed expression pattern of TAM receptors and ligands in the eye, to establish a role for ProS in retinal homeostasis, and to utilize the unique model to better understand the TAM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Flow duct acoustics: A practical demonstration to noise source reconstruction' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Due to the expected air transport growth, there is a strong need to develop novel noise reduction techniques in order to achieve further significant noise improvements at acceptable cost. Such solutions require a sound characterisation of aeroacoustic sources in the nacelle acoustic duct problem. The main goal of this project is to determine the practical capability of model-based methods in order to reconstruct a given acoustic source distribution in ducted flows, which remains a challenging and open problem. These equivalent models could be further used to devise new strategies for actively reducing the noise radiated from the intake of turbofan engines.The project will investigate the characteristics of in-duct source distributions from the measurements of the pressure field radiated by the intake and from internal aeroacoustic measurements, with a hybrid analysis based on the combination between up-to-date inverse methods and novel measurement techniques. The investigation would be performed on a laboratory-based flow duct acoustic facility installed in the anechoic chamber of the host institution. After the theoretical analysis of inverse methods for noise source reconstruction in a duct with and without flow, the accuracy and the spatial resolution of t he reconstructed source distributions using the testing platform for several source and flow configurations will be practically estimated.The researcher has a strong interest in developing her future career in European universities or automotive and aeronautics companies working with growing problems of noise source characterization. The research training proposed will provide her with a deeper understanding of the influence of mean flow on noise source reconstruction, used in aeronautics, in conjunction with novel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Synthetic Expansion of Magnetic Molecules Into Spintronic Devices' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Molecular spintronics is emerging as a rapidly growing field at the interface of inorganic molecular chemistry, surface sciences, and condensed matter physics fueled by both the fundamental interest in the underlying charge and spin transport mechanisms, and the prospects of the combined exploitation of molecular charge and spin states in a revolutionary new class of molecular-based ultra-low power devices translating their spin/charge response characteristics into novel, non-trivial functionalities. The research project proposes a range of innovative synthetic functionalization strategies of magnetic molecules that allow for targeted multi-terminal contacting of individual molecules in an approach representing a paradigm shift from existing top-down contact techniques in molecular spintronics. The project aims to reverse this existing approach and focuses on multi-step growth, controllable at the molecular level, of metallic electrode structures directly originating at a molecular magnet, as well as on controlled anchoring of the magnetic molecules to metal oxide surfaces of gate electrodes. Central to the proposal are magnetically functionalized polyoxometalates which provide a range of advantages relevant to molecular spintronics such as high stability, redox activity, structural versatility, tuneability of their molecular magnetic structures, as well growth strategies of metallic nanostructures such as quantum size-effect-controlled growth of metallic island structures. The synthetic expansion of molecule-attached metal nanocluster precursor structures into functional multi-terminal contacts addressable by multi-tip STM setups will lead to a breakthrough in reproducible charge transport measurements of single magnetic molecules and access to their fascinating Kondo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Genome-wide screen of aggregation selection' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

As protein aggregation is associated with numerous neurodegenerative diseases, several groups study the mechanism of aggregation formation and its regulation within the cell. However, besides the association with disease, some aggregates also have a functional purpose, e.g. temporary storage of hormones. This suggests that the outcome on cell fitness is determined by the relative contribution of aggregation formation, and its effect: either loss-of-function or gain-of-function.Previous genome-wide screens already identified important processes to maintain proteome stability, but none of these quantifies the origin of the aggregation effect or considers that aggregation could be beneficial for the cell. Knowledge of how each of these are regulated, is essential to obtain a complete model of the aggregation process.Recently, the host lab developed a unique method, based on a population genetics approach using yeast, that is able to simulate these toxic and beneficial effects triggered by the aggregation process. By exploiting this model using knock-out studies, I will determine the impact of each knock-out on cell fitness, quantify what is contributing to this effect (e.g. gain-of-function) and decipher how the knock-out influences the protein aggregation process. This knowledge will allow us to explore new drug targets in order to control protein aggregation.


**Keywords:** protein aggregation ,  cell fitness ,  deep sequencing ,  automated high-throughput microscopy ,  network analysis