RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Proteasomal degradation of toxic intracellular amyloid-beta protein by nanobody-enabled proximity to ubiquitin ligase' (Protambbody) under Horizon Europe.

assistant: **Objectives**

The amyloid-beta (A) protein arises from the sequential proteolytic cleavage of A precursor protein (APP). The accumulation of A oligomers has been regarded as the causal factor of Alzheimers disease (AD). Basal metabolic production of the A peptide is typical in healthy people, and its production rate is normally lower than its rate of clearance. In AD, the uncontrolled accumulation of toxic forms of A stemming from problems in its clearance and degradation results in memory loss, chronic neuroinflammation and neurodegeneration. AD is a leading cause of disability and death both in Europe and the world, and currently has no cure or clinically-proven disease-modifying therapies. There are over 10 million new cases of dementia each year worldwide (up to 80% of which are due to AD), implying one new case every 3.2 seconds. In Europe, about 10 million people currently suffer from this disease and about 50 million in the world; with these estimates projected to double by 2050. Thus, the identification of novel disease-modifying therapies has become very critical to eradicating AD from Europe and the world. My project proposes a radically novel approach in the AD field of utilizing the bodys cellular waste disposal system to selectively degrade A peptide, the causative agent of AD. This is in sharp contrast to the current approach of immunization against the A peptide, which has repeatedly failed to yield any cure or disease-modifying therapies for AD.This project will aim to identify the specific cytotoxic A peptides responsible for neuroinflammation and neurodegeneration in human induced pluripotent stem cells and target these peptides for degradation by the ubiquitin proteasome system. Emphasis will be on the cytotoxic A peptides of intracellular origin as emerging target
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Travel Companion enhancements and RIDE-sharing services syncronised to RAIL and Public Transport' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

RIDE2RAIL aims to integrate multiple (public/private/social) data sets and sources and existing transport platforms to promote an effective Ride Sharing practice of citizens, making it a complementary transport mode that extends public transport and rail networks. The RIDE2RAIL framework for intelligent mobility will integrate and harmonise real-time and diverse information about rail, public transport, ride-sharing and crowdsourcing in a social ecosystem, which will allow users to compare and choose between multiple options/services classified by a set of criteria – including environmental impact, travel time, comfort, cost – according to their preferences; this will make the travel experience both more positive for individual users, and globally more sustainable.This framework, consisting in a combined suite of travel offer classifications and software components, will be natively integrated into existing collective and on-demand transport services, connecting and reinforcing mobility offers, especially in rural and low-demand areas, in order to promote the access to high-capacity services (rail, bus and other public transport services), thanks to easy-to-use multimodal and integrated travel planning, booking and payment features. RIDE2RAIL will design, develop and test in real demonstrators a set of software components for the IP4 ecosystem, including advanced Travel Companion features and a crowd-based Transport Service Provider, which will foster the combination of flexible and regular multimodal mobility through an easy personalisation in diverse existing environments, thus facilitating the market uptake.RIDE2RAIL will deliver a set of validated proof of concepts and business cases envisaging future mobility scenarios, where advanced transport solutions will be se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The PRIvacy and Security MirrorS: “Towards a European framework for integrated decision making”' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The PRISMS project will analyse the traditional trade-off model between privacy and security and devise a more evidence-based perspective for reconciling privacy and security, trust and concern. It will examine how technologies aimed at enhancing security are subjecting citizens to an increasing amount of surveillance and, in many cases, causing infringements of privacy and fundamental rights. It will conduct both a multidisciplinary inquiry into the concepts of privacy and security and their relationships and an EU-wide survey to determine whether people evaluate the introduction of security technologies in terms of a trade-off. As a result, the project will determine the factors that affect public assessment of the security and privacy implications of a given security technology. The project will use these results to devise a decision support system providing users (those who deploy and operate security systems) insight into the pros and cons, constraints and limits of specific security investments compared to alternatives taking into account a wider society context.The project will achieve these results through a set of work packages providing an analysis of security and privacy technologies (WP2), a policy assessment of security and privacy (WP3), a criminological analysis (WP4), a legal perspective (WP5), a discourse analysis of media attention to privacy, security and trust issues (WP6) and an analysis of existing public opinion surveys (WP7). The findings of these WPs will be integrated (WP8) as part of the preparations for our survey (WP9), the first of its kind to sample public opinion in all Member States on these issues. The survey findings, together with the expert findings from WPs 2 – 7, will be analysed and interpreted in WP10 and form the basis for the d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of full size electric bus with second generation fuel cells stacks' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Objectives Increasing demand for zero emission transport in densely populated areas is usually provided for by electric systems, which are either limited in range (battery) or require heavy infrastructures (trolleys, trams). The objective of the project is the realisation of a pre-commercial fuel cell powered electric bus with high energy efficiency, which will be environmentally compatible (ZEV vehicle), without range limitation and autonomous. Technical Approach A 35-50 kW PEM hydrogen/air fuel cell will be installed in hybrid combination with an energy buffer, allowing energy recovery when slowing or braking. The energy buffer will consist of an advanced Magneto Dynamic Storage (MDS) system and the energy flows between the fuel cell, the MDS and the electric motor will be managed by a special electronic component (Power Sources Integrator) in order to minimise the global energy consumption. The fuel cell and all its ancilliaries will be packaged in a self contained Power Module that will replace the original ICE in the engine bay of a Neoplan N4114 city bus. A significant task will be the industrialisation of the fuel cell technology, in order to make available a really low-cost, fuel cell capable of being mass produced. Expected Achievements and Exploitation The claimed innovative aspects of this project include:  Development of the fuel cell technology, intended as a step forward from existing technology (FEVER Project), developing a stack with a unit power in the range of 10-17 kW, and demonstrating possibilities for cost reduction as low as 300 ECU/kW.  Re-design of the fuel cell system (power module), i.e. all auxiliary components and subsystems needed for operating the fuel cells, in order to improve efficiency and significantly reduce weight and volume (2 to 3
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Chemical signalling between microbial films and spores of the marine macroalga Ulva' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The aim of this project is to gain knowledge of processes in the early stages of marine bio fouling. This is an important and expensive problem and recent estimates suggest that the worldwide annual cost to shipping and marine industries is more than US$6 billion. Current attempts to control bio fouling rely on toxic chemicals and alternative ways not detrimental to the marine environment are urgently needed.This fellowship will allow the researcher to combine her existing expertise on bio hydrodynamics with the expertise in microbial ecology of the Plymouth Marine Laboratory (PML) and to develop a thorough understanding of the biological processes involved in bio fouling. The seaweed Ulva, which is a cosmopolitan intertidal macroalgae, is a highly successful bio-fouling organism.The reproductive stages, spores, are motile and settle onto a hard surface where they develop into a new plant. Settlement involves a process of `sensing a surface, and a choice of whether to attach permanently or move to another more suitable surface. Many factors are known to influence spore surface-selection but work at PML has shown that the presence of bacterial bio films is essential. In addition, the PML group has shown that spores respond to the chemical signal molecules that bacteria produce and use to communicate with other bacteria, a process known as quorum sensing".This fellowship will allow the researcher to gain expertise in the microbiology of surfaces and of how Ulva spores exploit bacterial signal molecules. It will complement her existing knowledge of the influence of water flows on spore settlement. The collaboration provides an opportunity to investigate new questions relating to how variable water flow dilutes the bacterial signal molecules in marine bio films. The researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Developing an integrative framework of goal flexibility, depression, and anxiety symptomatology' (GoalFlex).

assistant: **Concept**

Mental health is a global priority, with disorders such as depression and anxiety projected to become leading causes of disease worldwide by 2030. This underscores the urgent need for innovative research to understand protective factors and inform preventive measures. My fellowship aims to explore the potential protective effects of goal flexibility—the ability to adjust one’s goals and strategies in goal pursuit—against the development of depression and anxiety symptoms in emerging adults. Currently, we have limited understanding of how goal flexibility and mental health dynamics unfold over time or how and when to promote goal flexibility. By developing an integrative conceptual framework and adopting contemporary dynamic approaches such as ecological momentary assessment and computational modelling, I will demonstrate how these processes unfold over time. In this fellowship, I will pursue three research objectives: firstly, I will conduct a systematic review to develop a new conceptual framework linking goal flexibility and mental health processes; second, I will perform an empirical study using ecological momentary assessment to preliminarily evaluate the framework; and third, I will utilize computational modelling to simulate the proposed model, and to refine the conceptual framework. By achieving these objectives, this fellowship will guide future practices in developing personalized interventions for depression and anxiety. It will identify modifiable factors at critical time points, enabling the prevention or reversal of mental health symptoms.


**Keywords:** goal pursuit; depression; anxiety; goal theory; motivation; personality; mental health; psychological framework development; goal persistence; goal disengagement; well-being; goal adjustment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'AI-driven IP Intelligence Engine for Drug Discovery' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Today, new drug development on average costs $2.6 billion and takes 10-14 years. But, for example, the global health emergencyover the spread of the deadly new coronavirus, is proving to be a crucial real-life test case for industry to aim dramatically reduce thetime it takes to create new vaccines and drugs to combat emerging pandemics. While AI technologies help to identify thousands ofnew molecules that could be turned into potential medicines, it`s crucial to quickly establish the novelty of the most promisingcandidates. Therefore, more than 135 million patents, 70 million journal articles, and 4 billion web pages are published creating a vastcorpus, Big Data of information that potentially needs to be searched to establish, for example, the novelty of a product, the state ofthe art in the field of interest or the variety of components within complex compositions. Besides, 88% of the Big Data is unstructured(in form of texts) and its volume increases by a staggering 62% annually, according to IDC. It leads to the main challenge: there issimply way too much data for any human to read, analyze and understand.Semantic Intelligence develops an AI-driven IP intelligence Engine enabling users to search, analyze and extract complex knowledgeon chemical-biological interactions in patents. Our proprietary State-of-the-art technology combines Natural Language Processing +Machine Learning + Full linguistic data analysis + Chemical structure processing and Image Recognition, delivering novel ways byintegrating two languages: chemical structure and words, into a single semantic meaning. The target audience for this solution issmall and medium-sized life science companies, which currently have limitations in accessing expensive biochemistry databases. Weare aiming to disrupt the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Policy Design and Evaluation Research in Developing Countries', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Good policy design requires understanding of how agents respond to incentives and how they interact through market and non-market institutions. New approaches to policy design have recently emerged. These rely on controlled experiments as well as analysis of natural policy experiments. They allow us not only to evaluate whether a policy has been successful but also to test the theoretical channels through which the policy is assumed to operate. This can help us generate more effective policies.PODER will train a new generation of European doctoral students in the use of these techniques to design and evaluate policies to fight poverty. The training will combine coursework and methodological tools taught at the academic nodes with on-site training in project management and data collection learnt from private sector partners. PODER’s research agenda will be organized around three workpackages: health and education, private sector development, and governance, political economy and institutions. PODER aims reduce the US-Europe gap in the quality and impact of development economics research.The network will have an impact in three dimensions. It will reorient both the content and approach to doctoral training in development economics, adding a new focus on rigorous techniques for the assessment of alternative policy designs and an emphasis on fieldwork. This will enhance the career prospects of the network’s ESRs and ERs. Second, PODER will help create a durable European infrastructure for research training in development economics, by allowing researchers to take advantage of training opportunities beyond their own institutions and to interact with other researchers working on similar projects in different countries. Third, PODER has a unique set of relationships with donor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'An empowering toolkit for general practitioners to prevent, detect and treat melanoma (Dermtest)', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The aim of the innovation project Dermtest is to develop a toolkit for general practitioners (GPs) to empower them in taking charge of patient management in melanoma prevention, detection and treatment. Melanoma is a growing form of cancer accounting for up to 3% of all cancer incidences in Europe. Problems regarding the health systems in Europe (cost-pressure, low access to specialists, long waiting times, lack of integration, weak primary care) set barriers for early detection and on-time treatment. Yet only if melanoma is detected and treated early, the chance of cure is high. GPs as the first contact for a patient can help, but currently they do not have the necessary tools to do that.  We propose a toolkit for GPs, which will combine (1) teledermoscopy – remote and fast dermatologist consultation and diagnosis confirmation based on a digital image made by the GP, (2) a smart-phone app for pre-screening of moles, (3) decision support with new diagnostic hardware, (4) integrated software for good communication of patient data between the GP and other specialists (dermatologist, surgeon, pathology lab) and (5) an e-marketplace for allowing quick access to dermatologists’ opinion in different markets. By using teledermoscopy, already 700 remote consultations have been provided to GPs. The full toolkit is an innovative combination of state-of-the-art technologies ensuring fluent care provision and communication.The solution seeks to change the existing European market by shifting a greater role of melanoma prevention and treatment to the more than 450 000 GPs in the region. Empowering the GP in melanoma management would reduce waiting times for patients and increase earlier detection rates and provide on-time treatment – in the end, this means lower melanoma mortality i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ecology and effects of parasites in marine zooplankton.' (1998-2002).

assistant: **Innovation**

Protistan parasites/symbionts of marine zooplankton will be studied in the field and in laboratory experiments. The aim is to obtain new quantitative and qualitative knowledge on the biology of parasites and their importance to the population biology of the hosts.