RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Sensing Aberrant Transcription by MYC Multimers'.

assistant: **Concept**

Deregulated expression of MYC or one of its paralogues, MYCN and MYCL, maintains the growth of most human tumors. All current models explain the oncogenic potential of MYC proteins by their ability to form complexes with MAX that universally bind to active promoters and the ability of these complexes to induce a tumor-specific gene expression pattern. While MYC conforms to this model during unperturbed cell growth, we have discovered two paradigmatic situations in which MYC proteins undergo fundamental changes in their biochemical state, association with MAX and localization on chromatin: In response to pharmacological or physical disruption of transcription elongation, MYC moves away from active promoters to form large, spherical multimers that surround stalled replication forks. These multimers contain transcription termination factors and form a zone that shields stalled forks from RNA polymerase. Second, MYCN forms high molecular weight complexes during the S phase of the cell cycle that do not contain MAX and, like MYC multimers, contain termination factors. Their assembly depends on RNA that is normally degraded by the nuclear exosome, arguing that they too form in response to aberrant transcription. The switch between heterodimeric and multimeric states depends on non-proteolytic ubiquitylation of MYC, which alters protein-protein interactions that retain MYC at promoters. Our data show that MYC proteins exist in a hitherto unknown dynamic equilibrium between globally promoter-bound heterodimers and multimers that form locally in response to perturbed transcription. We aim to show that these dynamics enable tumor cells to cope with stress arising from deregulated transcription and are crucial for MYC´s oncogenic function. We expect that inhibiting MYC multimeriza
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Consultation meeting to reach consensus on approaches to enhance european research capacity in the behavioural and social sciences relevant to the prevention and management of cancer (EUCANSOC)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Cancer represents a major health burden within the European Union comprising some 200 different diseases. 4.5 million people suffer from cancer , there are 1 .6 million new cases each year and 1 million die of the disease despite the considerable advances in prevention, early diagnosis and treatment. A major research deficiency which was identified at the meeting of the Cancer Forum (5 November 2001) was for the development of research in the behavioural and social sciences relevant to the prevention, diagnosis and treatment of cancer. Support is sought for a two stage consultation meeting to reach consensus on the most effective means to enhance research capacity and develop an integrated research strategy at the European level. These objectives will underpin the development of other initiatives being promoted by the Cancer Forum and will contribute to the establishment of the European Research Area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Training network Of PhD researchers on Innovative EMI analysis and power Applications: ETOPIA' (ETOPIA), addressing dissemination and exploitation.

assistant: **Impact**

Our modern society becomes highly interconnected where power supply is not only providing energy between many distributed sources and loads but are also a main path of interference, especially in large complex systems, platforms and facilities, where interoperability of the electronic systems has to be achieved. There is an urgent need to train new researchers with a closer interaction of electrical power and power electronics with information technology and communications equipment. The ETOPIA consortium of key academic partners, supported by industry, has been brought together not only to train a sufficient number of qualified researchers but also to provide the fundamental research that underpins future technological developments. The detailed coordinated multidisciplinary multinational doctoral training program will provide the trainee researchers with a complete broad experience and at the same time allow them to develop and eventually lead their focused area of research. The program will focus on the development of novel methods to model, simulate, design, evaluate, measure and monitor. ETOPIA will also develop corrective economical measures for a safe, reliable, efficient and greener electrical power distribution system in and between buildings and vehicles. Specific innovations expected to be achieved through ETOPIA are methodologies to optimize the design of complex electrical/electronic installations with respect to compatibility and efficiency. Dissemination methods to realize optimal impact will include scientific publications, presentations and workshops, summer schools, training of engineers in industry and dissemination through newsletters, interviews, school visits, websites and social media.


**Keywords:** interference
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modelling And Characterisation for Reliability Of Silicon MEMS' in the context of a Fifth Framework call.

assistant: **Objectives**

MACROS addresses the modelling and simulation methodology of MEMS, in order to accurately verify the performance and characterise the impact of faults and defects, by extending existing component models and developing an efficient analytical modelling methodology. The technical results from this project will be verified and demonstrated on both a TANG oscillator and a microactuator for hard disk drive applications. These commercial applications will support the exploitation of results into better design and manufacturing validation procedures for MEMS customers. The modelling methodology will be demonstrated through an enhanced commercial VHDL-AMS simulation environment, prototype Cosserat simulator, and model generation methodology. Exploitation within MACROS will be aimed at MEMS modelling and services and at the dissemination through international conferences and academic courses.OBJECTIVESEfficient design and manufacture of MEMS products is still restricted due to difficulties in establishing a modelling and simulation methodology that can accurately verify performance over the full specification space, characterise the impact of both potential faults and defects within the manufacturing process and predict the effect of external environmental parameters such as thermal stress.MACROS will address these problems through:- extension of existing MEMS component models to include critical package induced stress, damping mechanisms, pre-stress and failure modes,- development of an efficient analytical modelling and simulation environment through the use of Cosseratt theory to support component level model generation,- integration of the resulting methodology into a VHDL-AMS simulation environment.DESCRIPTION OF WORKMACROS will be carried out by three partners, two industr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'AUTOmating MATerial modeling for composable and learnable behaviors' to be submitted under Horizon Europe.

assistant: **Abstract**

AUTOMATIX addresses challenges in constitutive material modeling by integrating machine learning with existing material knowledge in solid mechanics. Constitutive models are crucial for predicting material behavior under various loading and environmental conditions, yet traditional approaches often struggle to represent complex, non-linear, and time-dependent behaviors, limiting their accuracy across engineering applications. This project aims to bridge this gap by developing Material-Informed Neural Networks (MINNs), which combine empirical data with established mathematical structures to enhance interpretability, data efficiency, and predictive accuracy. By creating a modular, high-performance open-source library, the project will enable flexible modeling of complex material behaviors like plasticity, viscoelasticity, and damage mechanics. To improve generalizability and data efficiency compared to black-box ML models, the AUTOMATIX framework incorporates mathematical structures and partial material knowledge directly into a modern machine learning architecture. This gray-box approach allows MINNs to require less data while providing interpretable predictions aligned with known physical principles like thermodynamics. The framework is expected to enhance modeling accuracy in civil and mechanical engineering while advancing data-driven material modeling in multiphysics and multiscale systems. The project will test its approach on real-world applications of 3D printed fiber-reinforced concrete, which presents distinct challenges like layer-wise anisotropy, complex curing conditions, and various damage mechanisms, necessitating models that capture both microstructural and macroscale responses. By merging innovations from machine learning with material knowledge, the proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Providing tools to prevent emergence of enteric viruses' under Sixth Framework.

assistant: **Concept**

Food- and waterborne transmission play an important role in the spread of norovirus (NV, previously named Norwalk-like viruses) throughout Europe. NV are ubiquitous, highly contagious, and cause large international outbreaks of gastro-enteritis. This is of concern: current quality control for food and water in Europe measures bacterial contamination, and does not monitor viral contamination.Therefore, food can pass microbiological quality control, but still contain viruses. Matched with the virtual absence of a surveillance system for detection of common-source outbreaks of illness due to enteric viruses, this highlights a weak spot in European infectious disease control. The NV in fact serve as sentinels: when present, common-source outbreaks will relatively easily be detected due to the high attack rate and short incubation period.More insidious, however, are the enteroviruses and faecally-transmitted hepatitis viruses with a high proportion of asymptomatic infection after an incubation period of up to 2 months. These viruses cause illnesses like hepatitis (hepatitis A and E viruses) and infections of the central nervous system (enteroviruses). Signalling common source outbreaks with these viruses is virtually impossible without a strong (molecular) laboratory component to underpin the epidemiological investigations, aided by international exchange of laboratory data.The work in this proposal aims at providing the laboratory tools needed for successful (epidemiological) surveillance networks on food-borne outbreaks, hepatitis A viruses, and rare and emerging diseases (attributable to enteric viruses) that are being developed under DG Sanco's Communicable Disease Surveillance Network.We build on information gathered through a previously funded (FP5) research network, i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Thawing Carbon From LAND to SEA: Microbial Degradation of Organic Matter and Response to Thawing Permafrost in the Northeast Siberian Land-Shelf System' (TCFLAND2SEA) under Horizon 2020.

assistant: **Objectives**

Arctic permafrost (PF) as vulnerable carbon stock to global warming is increasingly receiving attention due to significant importance in global climate change. Immense carbon stock is held in surface soils on land, coastal Pleistocene Ice Complex Deposit and sediment of shallow subsea in Arctic. Under global warming, the emission of greenhouse gases CO2 and CH4 from PF could further intensify global warming; however, the key link between thawing PF and greenhouse gas emission -microbial degradation remains poorly understood. Microbial degradation of organic matter and its response to thawing is conducive to understanding the biogeochemical carbon cycle and even the future prediction of greenhouse gases in Arctic. To better understand microbial mediation on PF-carbon feedback to global warming, this proposal aims to quantitatively estimate the microbial activity and metabolism in different types of PF (inland, coastal Ice Complex Deposit and marine sediment of subsea PF) from the northeast Siberian via multidisciplinary techniques including microcosm incubation, lipid-based stable isotope probing, modelled metabolic flux analysis and metabolomics. This proposal will improve the understanding of microbial ecosystem in response to thawing PF and their roles in biogeochemical carbon cycle in Arctic.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Twinning on Functional Layered Materials for Advanced Applications' to be submitted under Horizon Europe.

assistant: **Abstract**

Radical technological transformation in the last one hundred years have been based on the understanding electronic properties of materials that has enabled their application in electronics, energy harvesting, among others.  There is no doubt that the solution to the new challenges of our time will also come from the understanding of materials and their applications. In this context, layered materials are very promising on account of their broad range of electronic properties, including insulators, semiconductors, conductors, superconductors, ferromagnets and antiferromagnets, that can lead to a variety of applications. FUNLAYERS will focus on two types of applications, energy storage and spintronics.The exploration of layered materials is such a vast enterprise that requires the engagement of an army of different institutions.  There is a huge effort, worldwide, and if Europe wants to remain competitive and be a major player in this incoming revolution, it is essential to strengthen the capabilities of institutions everywhere, most notably in widening countries. FUNLAYERS will bring together three partners to march together in this direction, two consolidated research institutions with outstanding scientific reputation, MPG and ALBA-CELLS, and INL, in Portugal. Taking advantage of incipient collaborations in layered materials, this twinning exercise will put INL to speed in this blooming research field and will benefit all partners thanks to their complementary strengths.FUNLAYERS will identify weak points in INL research capacity, and provide training, knowledge sharing, exchange of good practices and access to facilities to address these points. It will engage the three partners in collaborative research aiming at high impact results, and lay the foundations to sustai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The care and management of services for older people in europe network' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

This network of research and service-delivery organisations will examine how services for older people can be better managed by exploring the efficiency, quality and user-acceptability of different modes of health and social care services for older people. The network wills1. Focus on the efficiency of integration between three interfaces of care: Primary care (at home) and acute hospitals; acute hospitals and long/short stay residential homes; residential homes and primary care.2. Determine factors that inhibit and promote effective integration3. Examine the coordination of services within primary care and between primary care and social services4. Explore the whole-systems planning & policy implications of 1.2 above 5. Establish a website & database, organise workshops, publish findings, encourage pilot projects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'MULTIFUNCTIONAL APPROACHES TO UNDERSTANDING CRANIOFACIAL ABNORMALITIES'.

assistant: **Objectives**

Craniofacial development is a relatively neglected area of research, in part due to its complexity, and research is often fragmented preventing any real headway to be gained. Yet it is an important clinical problem affecting over 0.75 % of live births worldwide. Such craniofacial malformations, include facial and tooth disorders, cleft lip and palate, muscular and skeletal pathologies, deafness and blindness, and can be debilitating having not only physical but also social consequences. Birth defects are the leading cause of infant mortality accounting for 1 in 5 infant deaths, and contribute to potential life loss and/or long-term disability. The department of craniofacial development has a unique and core group of internationally recognised scientists who have the complementary expertise to address many fundamental aspects of craniofacial biology. Thus the department encompasses researchers investigating all aspects of craniofacial biology from facial patterning to tissue differentiation. The unifying theme of this research is to understand how craniofacial disorders and disease occur. The proposal aims to train junior scientists in this area of research so that they acquire a broad range of technical and transferable skills. A structured programme of laboratory research and lectures will achieve this. Students will carry out feasible but innovative research projects and will be supervised directly by one main supervisor allowing frequent contact and individualised training. They will also undertake foundation training in technical skills at the forefront of research technology and will attend core tutorials in craniofacial and cell biology. In addition they will attend journal clubs and seminars that will ensure they gain skills in presentation and critical scientifi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multifunctional Magnetic Nanoparticles: Towards Smart Drugs Design', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Nature has been utilizing nanostructures for billion of years. The following two properties, (i) being about the size of typical biological objects and (ii) the possibility of tailoring their properties by changing their size, make nanoparticles attractive for biomedical applications. Using nanoparticles to deliver drugs to tumours offers an attractive possibility to avoid obstacles that occur during conventional systemic drug administration. This NANOPUZZLE project pretends to develop an innovative controlled release methodology, based on hyperthermia and magnetic nanoparticles, as platform for the incorporation of different molecules with different functionalities, to obtain a multifunctional system for cancer treatment and diagnose that leads antitumoral drugs discharge only in the tumoral area. Multifunctional magnetic nanoparticles loaded with a targeting agent (folic acid) and a potent antitumoral drug (doxorubicin) will be prepared. These active molecules will be coupled to the magnetic nanoparticles (MNPs) due to complementary oligonucleotides strands (oligo-zipper). Due to the magnetic properties of these nanomaterials, a local heating induced by an alternating magnetic field, will release the drug in the desired target as a consequence of the DNA denaturation (oligo-unzipping). For this approach, the increase of temperature is only required directly in the nanoparticles and the heating of the surroundings is not needed. For instance, less quantity of nanoparticles and a weaker external magnetic field will be required, avoiding the main inconveniences of conventional hyperthermia treatments. Furthermore, the superparamagnetic properties of these MNPs will also allow their use as contrast agents for tracking and diagnosis by magnetic resonance imaging (MRI).