RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Self-assembled 2D Chiral Plasmene Nanosheets for Biomarker Detection Based on Surface-Enhanced Raman Scattering' in the context of a Horizon Europe call.

assistant: **Objectives**

In this project, I will develop chemical methods to synthesize colloidal chiral plasmonic nanoparticles and assemble them into 2D plasmene nanosheets. Chiral components on the surface of metal nanocrystals enantioselectively interact with chiral growth-directing molecules, such as amino acids and peptides, leading to the asymmetric evolution of chiral plasmonic metal nanoparticles. The chirality transfer from soft chiral molecules to inorganic metal surfaces derive from the highly twisted surface features on the nanoparticles induced by the chiral molecules during overgrowth. I will synthesize chiral plasmonic nanoparticles with different morphologies, finely tune the twisted surface elements, adjust their interparticle spacings and orientation, and optimize their chiroptical responses. Highly chiral 2D graphene-like plasmonic superlattices, or “plasmene nanosheets”, will then be fabricated on flexible substrates to serve as all-hot-spot practical chiral sensing platforms via control over interparticle spacing and orientation. A novel functional chiral plasmonic biosensing platform will be constructed by the self-assembled 2D chiral plasmene nanosheets, based on surface-enhanced Raman scattering, for ultrasensitive biomarker detection and chirality discrimination.


**Keywords:** Chiral plasmonics, circular dichroism, surface-enhanced Raman scattering, biomarker detection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'A SIOPEN pragmatic clinical trial to MOnitor NeuroblastomA relapse with LIquid biopsy Sensitive Analysis'.

assistant: **Objectives**

High-risk neuroblastoma accounts for 15% of cancer related-deaths in children. Half of the >1500 patients yearly diagnosed with neuroblastoma in the EU have high-risk disease, which will relapse or progress in half these cases after first-line treatment. Relapsed neuroblastoma is aggressive and often therapy-resistant. Monitoring for disease relapse and therapy response is crucial for the survival chance of these patients. The current standard-of-care for monitoring are imaging technologies and bone marrow assessment, which are costly, invasive and a burden for children, who often require anesthesia. These drawbacks limit how often is monitored. More sensitive, less invasive and less toxic monitoring techniques are needed. The mutational spectrum often changes in recurring tumors, which may explain therapy resistance and provide additional druggable targets. Imaging, however, provides no information about molecular characteristics. Liquid biopsy tests are minimally invasive, allow frequent sampling and sensitively detect tumor molecular markers in tumor-derived DNA and messenger RNA circulating in peripheral blood. MONALISA aims to close existing gaps and establish liquid biopsies as standard-of-care to monitor relapsed/refractory neuroblastoma, as a blueprint for other pediatric cancers. Reliable, early assessment of molecular progression or relapse is the main aim of the pragmatic randomized clinical trial proposed in MONALISA. We develop a digital decision support tool to help oncologists use the new monitoring and apply patient-reported outcomes to integrate patient viewpoints and assess the effect of minimally invasive, liquid biopsy diagnostics on quality of life. We will establish whether events can be detected earlier using liquid biopsy monitoring, and whether
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Uncovering the role of new synaptic adhesion molecules in encoding synaptic connectivity in the brain' in the context of a Seventh Framework call.

assistant: **Objectives**

Synapses connect neurons into a network that encodes our thoughts, memories and personalities. Loss of synaptic connectivity is thought to underlie a variety of cognitive disorders such as autism, schizophrenia and Alzheimer’s disease, but little is known about the molecules and mechanisms that establish and maintain the precise patterns of synaptic connectivity in the brain. Neither is it understood how perturbed synaptic connectivity affects cognitive function. The synaptic adhesion molecules that connect pre- and postsynaptic partners across the synaptic cleft provide the key to understand these processes.I hypothesize that the proper formation and function of synaptic connections depends on synapse-specific complexes of adhesion molecules. Together, these complexes form a synaptic adhesion code that specifies synaptic connectivity and contributes to the functional and structural diversity of synapses in the brain. In my preliminary studies, I have identified a large complex of novel synaptic adhesion molecules that is required for normal synapse function, and is ideally suited to confer precise synaptic connectivity. Using in vivo manipulation of these novel synaptic adhesion molecules, I will uncover how the diversity in synaptic adhesion complexes contributes to the specification of synaptic connectivity and the diversity of synapses. Furthermore, I will determine how loss of these novel adhesion molecules affects cognitive function. This will yield new insights in the molecular and cellular mechanisms that underlie the establishment of precise synaptic connectivity in the brain. Ultimately, this insight will guide the development of new strategies for the treatment of cognitive disorders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nanoscale Magnetization Dynamics' (NOMAD), addressing dissemination and exploitation.

assistant: **Impact**

The aim of NOMAD is to develop frontier approaches to control the magnetodynamic properties of nanometer-sized molecular and metallic elements. The first part of the project recognizes the importance of molecular materials for future technologies based on magnetoelectronic devices. It addresses the stabilization of the magnetic moment of individual molecules beyond their intrinsic limits (slow timescale). Moreover, the construction of spin-sensitive probes with spatial atomic-resolution and a dynamic range extending up to the GHz regime is proposed. These shall be used to characterize magnetodynamic phenomena of individual molecules and metal particles in a nanoscopic environment (fast timescale). The second part relates to the control of magnetic relaxation and coercivity in nanoscale metallic particles. Electric-field manipulation of ferromagnetism has been proven in dilute magnetic semiconductors at temperatures below 50 K. Here, the aim is to demonstrate and optimize electric field-induced changes of the magnetic anisotropy energy in metal layers and nanoparticles embedded in a double tunnel junction, providing a direct or indirect (transition-driven) handle to their magnetic dynamics at room temperature. Metal-based materials constitute the mainstay of present magnetic technology; their electric-field actuation would lead to simpler and power-saving devices that process magnetic information using electrical signals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'MEMS ATOMIC CLOCKS FOR TIMING, FREQUENCY CONTROL AND COMMUNICATIONS' (MAC-TFC) under Seventh Framework.

assistant: **Objectives**

Atomic clocks provide enhanced accuracy, stability, and timing precision compared to quartz-based technologies. However, the size and power consumption of existing atomic clocks far exceeds that those of quartz-based clocks, not preventing their deployment in portable applications.The goal of the MAC-TFC proposal is to develop and demonstrate all the necessary technology to achieve an ultra-miniaturised, low-power an ultra-miniaturised caesium atomic clock, presenting a short-term stability of 5x10-11 over 1 hour while operating on the power of an AA battery, with less than 200 mW power consumption.Phased technology development approaches are planned. The first phase focuses on establishing theoretical limits of MEMS atomic clocks and demonstrating practical design and fabrication feasibilities, optimizing the performances of atomic resonator. Then, the second phase of proposal aims at demonstrating and developing the technologies of the building blocks for the miniaturized clock including a fully customised semiconductor laser, an innovative approach of filing the clock cell with alkali vapour and a low-power ASIC for the analog Radio Frequency (RF) electronics. The third phase is concentrated on the final chip-level integration and package of two alternative prototypes of MEMS atomic clock using LTCC technology. The physics package includes a micromachined cell with well controlled alkali vapour, a semiconductor laser , collimatting/polarizing microoptical elements and a photodetector. Finally, a fourth phase is devoted to the testing the final assembly of the physics package together with the developed electronics, as well as setting the basis for technology transfer and pre-industrialisation for potential applications.To this aim, MAC-TFC brings together a consortiu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Application of practical experience gained from two recent large earthquakes in the south iceland seimic zone in the context of earthquake prediction research to develop technology for improving preparedness and mitigating risk' to be submitted under Fifth Framework.

assistant: **Abstract**

This proposal aims to develop technology and understanding needed for warning where, when and with what effects large earthquakes will strike. The Iceland Natural Laboratory" with its intensive earth activity and high level monitoring system is the test area for the project. The unique data collected for the large, Ms=6.6, June 2000 earthquakes in the South Iceland seismic zone will be used to test and validate the results. Another base for the proposal are the results of the EC projects PRENLAB and PRENLAB-2 (1996-2000). The project aims at establishing methodology for improving probabilistic hazard assessment, time dependent hazard assessment and for short-term warnings, to be implemented for active warning service."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Gestures in nonhuman and human primates, a landmark of language in the brain? Searching for the origins of brain specialization for language' under Horizon 2020.

assistant: **Concept**

Most of language functions are under the left brain control in both left- and right-handers and involve structural asymmetries between the two hemispheres. While this asymmetry was considered as associated with handedness, such a relation has been recently questioned. Considering the strong language/gesture links in humans and the continuities between the gestural system in apes and monkeys and some language properties, we recently suggested the hypothesis of a continuity between language lateralization and asymmetry of communicative gestures in both human and nonhuman primates. Given the phylogenetical proximity between those species, comparative research on brain specialization between a non-linguistic gestural system (i.e., in monkeys) versus a linguistic gestural systems in humans (i.e., sign language in deaf) might help evaluating the gestural continuities with language lateralization in term of manual asymmetries, structural and functional lateralization of the brain. To this purpose, a first objective is to evaluate the continuities of manual and brain asymmetries between (1) a linguistic gestural system in humans using MRI in 100 adult native deaf French signers, and (2) a non-linguistic gestural system of adult baboons Papio anubis using 106 MRI brain images.A second objective is to explore the functional brain lateralization of gestures production in baboons (versus manipulation) using non-invasive wireless Infrared Spectroscopy in 8 trained subjects within interactions with humans.A last innovative objective is to investigate, through the first non-invasive longitudinal MRI study conducted from birth to sexual maturity in primates, the development and heritability of brain structural asymmetries and their correlates with gesture asymmetries in 30 baboons.At b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dissecting the neutrophil-cancer cell interactome in the metastatic bone niche', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Bone is one of the most common organs for solid tumour metastasis. 75% of patients with late-stage breast cancer develop recurrence in bone. Current treatments are palliative, leaving this condition incurable, with an unmet need to identify new therapies. Inflammation is an important player in cancer. My pilot data show that depletion of a specific immune cell type, neutrophils, impairs bone metastasis in vivo, suggesting that neutrophils have tumour-supporting functions. However, the role of neutrophils in the metastatic bone niche remains largely unexplored, it is unknown whether they contribute to the seeding or the expansion phase of bone metastasis and if tumour cells regulate neutrophil plasticity, therefore skewing the balance towards pro-tumourigenic neutrophil subsets. I hypothesise that neutrophils acquire pro-tumourigenic phenotypes when in close proximity to cancer cells and support metastatic progression by regulating the tumour niche. By using a liposoluble fluorescent protein expressed by cancer cells, neighbouring neutrophils will be characterised: Neutrophil subsets will be identified by spectral cytometry, their transcriptomic signature analysed using RNA sequencing and their pro-tumourigenic role functionally assessed in vitro and in vivo. By employing a combination of MALDI-MSI and multiplex antibody-based imaging, neutrophil-cancer cell interactome will be established in order to identify candidate molecular mechanisms regulating neutrophil pro-tumourigenic functions. By using in vivo models of neutrophil extracellular traps (NETs) blockade, neutropenia, neutrophilia and enhanced neutrophil retention in the bone marrow, neutrophil candidate mechanisms shaping the metastatic niche will be determined. Dissecting the molecular mechanisms regulating pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Repression and deportation in the Stalin Era. The life and time of Iranian migrants in Caucasus' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The Project provides for writing a monograph titled Repressions and Deportations in the Stalin Era: Life and Time of Iranian Migrants in Soviet Caucasus". The topic of the research work is both of scientific and social-political interest. Embracing a wide range of questions - nearly 40-year complex and tragic page in the history of the Soviet Union, the research work attempts to throw light on the essence of authoritarian regimes, trace back the dangerous pernicious nature state totalitarianism in the destinies of millions of people, both local and foreign, who for different historical reasons, as the fates decreed, resided in the Soviet state in the first half of the 20 Century. Note that Stalinism is not solely historic-ideological and social-political phenomenon, typical for the Soviet Union only.Stalinism is a system of views and methods of state administration. Deportations and repressions were an integral part of terrorism methods, devised by Stalin, to ensure vital activities of the system. These methods were widely applied against all the peoples of the Soviet Union, including those residing in South Caucasus. The research work focuses on universal features of repressions and deportations in the Soviet Union, characteristic of all dictatorship - base d countries, distinctive features of Stalin persecutions, etc. The research work has first ever brought original archival documents into scientific use. Authors collected hundreds of original documents from archives of Russia, Azerbaijan, Iran, Georgia, Great Britain.Project will be based on the already tested methods to comply with the most advanced European and Soviet historiographers, free of any ideological dogmas and preconceptions. The Project also provides for delivering a course of lectures on the general hi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Corporation integrated intelligent multimedia assistant for field operators' (INTFO) under Fourth Framework.

assistant: **Objectives**

The aim of the project is to develop a flexible multimedia application to organise and improve the efficiency of operators performing every-day activities in the field. It will run on corporate information systems and on portable (mobile) personal computers, with cooperation between these two. It will help:- The company's operations managers to organise and allocate tasks to field operators. - The field operators to gather and validate multimedia geographic, alphanumeric and maintenance data (including voice register data and photographs) about existing equipment and facilities. It will also provide guidance and assistance in the inspection, maintenance, operation and modification of equipment.In order to provide this functionality, the application will be divided in two cooperative subsystems: A central subsystem, running in the local operational control centres, will connect to the corporate information system. A remote subsystem, running on portable computers that the operators carry in the field, will support the individual operators and may communicate online with the central subsystem if necessary.The application will be used in three main steps:1. All existing corporate data (photographs, voice registers, geographic, alphanumeric, operational, maintenance and other data) and related knowledge (rules, norms, constraints and other knowledge) about the company's facilities in a selected zone are downloaded from the central computer to the portable personal computer. 2. The operator visits the zone concerned. The application will help the operator to perform the activities required by providing intelligent multimedia support. New data will probably be generated from such activities. A real-time connection to the central system can be established where necessary, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Are you experienced? An exploration into the functions and value of consciousness' (EXPERIENCE), addressing dissemination and exploitation.

assistant: **Impact**

Why would we do anything at all if the doing was not doing something to us? In other words: What is consciousness good for? Here, reversing classical views according to which subjective experience is a mere epiphenomenon that affords no functional advantage, I propose that the core function of phenomenal experience is to enable subject-level valuation: What it feels like is endowed with intrinsic value. Thus, I argue that it is only in virtue of the fact that conscious agents experience things and care about those experiences that they are motivated to act in certain ways and that they prefer some states of affairs vs. others.  Conscious experience functions as a mental currency of sorts that makes it possible for agents to compare vastly different states of affairs in a common subject-centred mental quality space  a feature that explains that consciousness is unified. While my previous work was focused on the how question of consciousness, here, I propose to focus on the even more challenging question of the why of consciousness. EXPERIENCE will address this issue by pursuing a rich interdisciplinary program rooted in integrative philosophy of mind and in innovative cognitive neuroscience methods applied to the interactions between affect and consciousness in perception and action. The project is articulated over four work packages, each addressing a specific claim: (1) Subjective experience has intrinsic value, (2) The phenomenal field is valenced, (3) All intentional action is motivated by subjective experience & (4) Subjective experience has functional effects. EXPERIENCE is high-risk, for the function of subjective experience is largely unexplored territory, and high-gain, for it promises to question entrenched distinctions and to move the scientific approach of co