RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Phenotypes and genes linked to insulin resistance and risk for type 2 diabetes', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Type 2 diabetes is a major global health problem, which is undergoing an epidemic development. Effective intervention and treatment require the understanding of the genetic and molecular mechanisms involved. The objectives of this proposal are to identify at least 800 healthy first-degree relatives to Type 2 diabetic subjects. And a similar control group lacking known genetic predisposition. Extensive and novel technology will be used to characterize clinical subphenotypes. Adipose and muscle biopsies will be obtained for analyses of gene expression using the novel cDNA array technology. Differentially expressed cDNAs will be identified and cloned and biological functions of novel proteins identified. Transgenic/knock-out animals will be generated to identify in vivo functions. In parallel, focused research will be performed aimed at identifying candidate genes, including intracellular signalling molecules and nuclear receptor transcription factors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'INNOVATIVE AND EFFICIENT SOLUTION FOR PRODUCTION IN MICROALGAE OF EASILY EXTRACTIBLE AND HIGHLY PURE ASTAXANTHIN FOR ADDED-VALUE PRODUCTS' under Horizon 2020.

assistant: **Concept**

Astaxanthin is a carotenoid with a high commercial value. Its high anti-oxidant activity makes Astaxanthin being used as a food/feed supplements, in cosmetics, and in nutraceutics. Microalgae are the main primary sources of Astaxanthin, being produced at industrial level mainly by cultivation of the green alga Haematococcus pluvialis with high costs for cultivation and extraction, hindering its market.In the ERC-StG-SOLENALGAE project the investigation of the role of carotenoids in photoprotection in microalgae led to the development of an innovative platform for Astaxanthin production.  Strains with high Astaxanthin accumulation were indeed obtained by metabolic engineering in the green alga Chlamydomonas reinhardtii (usually not accumulating Astaxanthin), producing up to 4 mg/L per day in non-optimized growth conditions. Astaxanthin production by bkt15 strain revealed unique advantages compared to other source of natural Astaxanthin: production of Astaxanthin in continuous, in a single cultivation step; high bio-accessibility for animal or human assimilation; easier extraction of astaxanthin even without costly cell pre-treatments; lower extraction costs and no contamination from oxidant molecules as chlorophylls during extraction process. These advantages lead to a potential increase in pure Astaxanthin productivity up to 16-fold higher than the current methods. ASTEASY PoC aims to the technological development of the new system, by optimizing the cultivation conditions and extraction processes of Astaxanthin from the bkt15 strain and validating the performances in 60 litres demonstrator units. We will also identify and protect the IP generated and analyse the certification needed for commercialization. A business plan will be drafted as a result of interactions with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'INNOVATION ASSOCIATE FOR RESEARCH, DEVELOPMENT, AND APPLICATION OF INTELLIGENT MODELLING FROM EARTH OBSERVATION DATA' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The envisaged innovation of our company is the development, implementation, and commercialization of a local short- to medium-term atmosphere forecasting Software-as-a-Service platform for climate and energy forecasting applications based on original self-learning modelling technologies from high-resolved space-based earth observation data maintained in a Big Data platform. For validating and realising the full potential of the innovation a number of complex and specialized tasks have to be executed in preparation of full-scale implementation. To complement our resources, knowledge and skills in order to further strengthen the competitive advantage of our geo-forecasting solutions we are hiring an Innovation Associate in Intelligent Inductive Modeling for further development of current concepts and preparation of follow-up EU/ESA/national innovation and commercialization project proposals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Towards a unified theory of surfaces 5' under Fourth Framework.

assistant: **Concept**

At the research level, this proposal aims to address the conjectured relations between the algebraic, diophantine,and hyperbolic geometry of surfaces,as conjectured by lang, vojta,bombieri et AL. Specifically it intends to concentrate on the relation between the algebraic and hyperbolic geometry (via my method of dynamic diophantine approximation) together with its topological implications,in addition the arithmetic consequences (particularly improvements in Roths's theorem) which the said method may have will be considered. In this respect,while further advanced and more sharply focused, the research themes are broadly similar to those ennunciated on obtaining my aforementioned research training grant. However,being of category 40 type, this proposal includes the intention to broaden the base of the neopolitan mathematical community through frequent lectures and seminars on this and related material.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'The Agri-environmental Footprint: Development of a common generic methodology for evaluating the effectiveness of European agri-environmental schemes.'.

assistant: **Innovation**

AE-FOOTPRINT will investigate and develop a common methodology for the environmental evaluation of the level of achievement of common objectives across European Agri-Environmental Schemes (AESs) which can be customised for the evaluation of locally-specific AES objectives. The methodology centres on the struction of an Agri-environmental Footprint Index (AFI) that can be used to measure and compare environmental impact of AESs by aggregating the measurement of a selected range of agri-environmental indicators. A series of tasks will be ducted to support the development of the AFI. A desk-based review will identify agri-environmental objectives that are common, shared or unique across a representative selection of EU Member States; agri-environmental indicators will then be selected that correspond to these various objectives. sultations with national AES experts and stakeholders will allocate weighting factors to individual objectives; differences in weighting factors will therefore reflect the relative priority of national/regional- level objectives. In this way, customisation of the AFI can be achieved. sultation exercises will be an important opportunity to engage with and inform a variety of stakeholders, policymakers and implementation agencies. We will assess the availability and utility of existing information-gathering exercises and their data sets e.g. national and EU-wide farm surveys. A feasibility analysis of the AFI will identify and prioritise any information gaps, and sider the benefits of alternative methods of implementing the AFI. We will use available data for appropriate indictors to calculate AFI scores to measure and compare the environmental performance of AES- participating and non-participating farms. AE-FOOTPRINT will also explore the use of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Baltic Consortium on Promoting Gender Equality in Marine Research Organisations' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Baltic Gender is a consortium of research organisations and higher education institutions from the Baltic Sea Region aiming at reducing gender segregation and gender inequalities in Marine Science and Technology. The diversity of the consortium members (from Nordic, Continental and Eastern countries) with regard to gender equality policies and practices as well as gatekeeping provides an excellent basis for exchange, comparison, collaborative learning and transfer of knowledge. The action will work toward the establishment and implementation of Gender Equality Plans (GEPs) as instruments that can catalyse institutional change. Collection, standardisation and evaluation of gender-segregated data will facilitate the establishment of gender-sensitive indicators and enable the consortium to develop concrete targets and measures for reaching the set goals of the GEPs and to monitor the progress of their implementation. GEP implementation activities will be supported by established approaches and innovative strategies developed in the four core work packages on (i) career advancement, (ii) work and family, (iii) structural changes, and (iv) gender dimension in marine research. Cross-cutting work packages will support action’s progress via giving trainings, strengthening networks, raising awareness, disseminating results and reaching out to a wider scientific community and public in general. The outputs are designed to maximize impact and, due to the inter-disciplinary nature of marine sciences, to have a broader impact in the field of natural science and technology. The deliverables include blogs, brochures, best-practice handbooks, recommendations, training-materials, synthesis reports. Schemes and good practices established during the action (e.g., grass-root networks, work
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SHocks: structure, AcceleRation, dissiPation' (SHARP).

assistant: **Innovation**

SHARP aims to achieve a major leap in understanding of the structure of collisionless shocks in various environments and of the acceleration processes at all shock scales. This will be done by: (a) intensifying exploitation of the heliospheric data and performing a comprehensive comparative analysis of the Earth bow shock, planerary shocks, and interplanetary shocks, (b) establishing a collaboration of the world renown groups working together on all aspects of the shock physics, (c) utilizing and combining the knowledge obtained in in situ measurements on heliospheric shocks and in remote observations of distant astrophysical shocks, and (d) developing a high-level databases of shocks and advanced tools for the shock analysis and making them public. The research will encompass the three ""pillars"" of the shock physics: the shock structure, the shock energy deposition, and the radiation from the shock energized particles. The study will address the most fundamental unsolved issues of the shock physics: the structural changes of the shock with the increase of the Mach number, the intimate relation between the shock fields and the particle distributions, the injection problem, and the electron acceleration puzzle. The research will bridge over the in situ observed heliospheric shocks and supernovae remnant (SNR) shocks which are observed only indirectly, by emission from energized particles, by combining the knowledge of the heliospheric shock structure and constraints provided by the radiation measurements from SNR shocks. Starting with the observational data, the research will ultimately provide new diagnostic measures for the ongoing and future experiments, such that will allow to improve the efficiency of the measurements and data analysis, contribute to understanding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Mechanisms of neuronal silencing in Alzheimer’s Disease – investigation of cellular and network mechanisms in mouse models of β-amyloidosis', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Alzheimer’s disease (AD) is defined by pathological brain changes, including the accumulation of β-amyloid and tau deposits over decades. In addition, data in human patients and rodent models indicate that neuronal dysfunctions, i.e., altered action potential firing rates, are further hallmarks of AD. Two forms of neuronal dysfunctions exist - neuronal hyperactivity at early stages, followed later by neuronal silencing. The causes of neuronal hyperactivity have been widely studied. However, the mechanisms of neuronal silencing are still incompletely understood, likely due to the high complexity of interdependent brain changes in late AD stages.MONSil-AD aims to unravel the multifactorial pathways leading to neuronal silencing in AD mouse models. My preliminary data indicate that silencing co-occurs with emergent tauopathy, loss of dendritic spines, and decreased presynaptic inputs in mouse models of β-amyloidosis. Moreover, the soluble ectodomain of the microglial ‘triggering receptor expressed on myeloid cells 2’ (sTREM2), which is upregulated in AD, suppresses neuronal activity. Based on these findings, I will investigate whether synaptic uncoupling from the circuit causes the silencing of individual neurons (aim 1) and test if intracellular tau accumulation silences neurons on a cellular level (aim 2). In addition, I will explore the contribution of sTREM2 to neuronal silencing in AD (aim 3) and the interactions between the three mechanisms. To reach the ambitious aims of MONSil-AD, I have implemented cutting-edge in vivo two-photon imaging techniques and developed specialized protocols enabling me, for the first time, to provide a comprehensive picture of the mechanisms leading to neuronal silencing in AD. In addition, MONSil-AD may have direct clinical implications
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Oberwolfach 06: Algebra, Number Theory, Geometry, Topology, and Applications' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Oberwolfach 06: This project is merged from proposals 29459 (Oberwolfach I06) and 29459 (Oberwolfach II06).It concerns the support of 16 conferences in 2006 at the Mathematisches Forschungsinstitut Oberwolfach (MFO) on modern developments and applications in Algebra, Number Theory, Geometry and Topology within the programme Marie Curie Conferences and Training Courses / Series of Events (SCF)", identifier FP6-2005-Mobility-4.The MFO is one of the leading mathematical research centres worldwide, which organises weekly high-level international conferences in all fields of mathematics and its applications.The aim of these conferences is to present the most recent developments and to discuss further research projects. Many important developments in mathematic s originated from one of these workshops and almost all relevant mathematical results were presented here and discussed by the leading experts.We apply for support of 256 eligible event participants and we propose an amount of 177.600 Euro for living expenses of the eligible event participants (including organisational costs) and 51.200 Euro for travel expenses."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Electron spin resonance spectroscopy in strongly correlated materials' (ESRISCOM) targeting Sixth Framework.

assistant: **Abstract**

The study of strongly correlated materials dominated the second half of the last century. The not exhaustive list of such materials and phenomena - where strong correlation effects give rise to unique behaviour - include superconductors, Mott-Hubbard insul ators with magnetically ordered ground states, materials with density wave ground states, and materials with more exotic states such as the Tomonaga-Luttinger liquid state. Understanding the fundamental phenomena behind strong correlation effects have moti vated numerous theoretical work, which has greatly affected the way many body quantum mechanical systems, and in particular condensed matters, are understood. On the applied side, this has contributed to a range of novel materials that has revolutionized t he today's world. The application of strongly correlated materials ranges from space research through electronics and military applications till medicine. Given the importance of the phenomena occuring for strongly correlated materials, further investigati on of such systems is highly desired. The emerging new materials that are desired to be investigated are carbon nanostructures, and novel superconductors such as MgB2 and organic superconductors. Here, the improvement of electron spin resonance instrumenta tion available at the host is proposed together with detailed study of these systems. The instrument will be dedicated to the research of these systems, however, it will also be offered part-time for other studies such as chemical systems and biological co mpounds. Thus, the proposal contributes to a wider area of research beyond its primary use. This is particularly important as the host is situated in a less developed region of the EU and it will also be beneficial for the reintegration of the applicant. T h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of a trivalent epitope-focused RSV vaccine to boost pre-existing immunity' (RSVTriVax) targeting Horizon 2020.

assistant: **Abstract**

The development of a Respiratory Syncytial Virus (RSV) vaccine is deemed a global health priority by the World Health Organization. Globally, RSV causes 33 million episodes of infection and up to 120,000 deaths annually. The most affected populations are pre-term infants, young children and the elderly. Several decades of intensive research are yet to yield a clinically approved vaccine. This failure is mostly attributed to sophisticated viral mechanisms that prevent the induction of protective antibodies (Abs). Using cutting-edge molecular design tools, we developed a novel vaccine candidate (TriVax) to focus immune responses in such key neutralization epitopes. TriVax is a cocktail composed of three epitope-focused immunogens mimicking three distinct neutralization epitopes targeted by potent neutralizing Abs. Our primary target populations are pregnant women (protection of pre-term infants) and elderly, where the challenge is to boost subdominant, neutralizing Abs elicited during previous natural infections. Recently, we showed that epitope-focused immunogens are exquisite at boosting subdominant functional Abs, and in this scenario, superior to the strongest competitor vaccine candidates. In a preliminary study in Non-Human Primates, TriVax showed great promise by eliciting robust neutralization on an RSV naïve cohort, suggesting a good safety profile and the potential to emerge as a competitive alternative for vaccine development. For manufacturing, epitope-focused immunogens are simple and stable molecules that can be produced at low cost. Overall, we propose a viable vaccine formulation to protect against an important pathogen which carries large financial burdens on public health systems. Thus, our proposal has an important societal and financial impact, and wil