RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Creation of Tokens in Late Antiquity. Religious 'tolerance' and 'intolerance' in Fourth and Fifth Centuries AD' to be submitted under Horizon 2020.

assistant: **Abstract**

This innovative project aims to investigate the phenomenon of the production of late-antique tokens as objects embodying the relations between different religious identities in Roman society. In particular, the study focuses on the so-called “Vota Publica coinage” (or “Festival of Isis coinage”) and “Asina tokens”, both minted in the Roman West during the fourth century and perhaps the fifth century AD. These issues are still partly unpublished and furnish valuable data. Since the creation of these “pagan” objects took place during the gradual repression of polytheistic cults by a Christian government, the project will shed light on the question of religious freedom and on the dynamics of religious “propaganda” during an era that saw the transformation of the pagan Roman Empire into a Christian one. Unlike traditional approaches, religious politics will be examined through the innovative perspective supplied by the numismatic evidence of tokens, which, as an expression of relationships, exchanges and culture, contain a remarkable informative potential for the understanding of broader aspects within ancient communities. Through this lens, the project will focus on specific social, religious, and cultural experiences in the context of the “conflict” between pagans and Christians in the fourth and fifth centuries AD. The adoption of an interdisciplinary approach and the mobilization of intellectual tools forged by classical disciplines will help to formulate appropriate patterns and to develop an analytical inquiry on the psychological, social, religious and political changes and interactions revealed by tokens in the late Roman empire.This project will therefore make a historical contribution to current reflections on religious “tolerance” and “intolerance” that have a si
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Estimation of the reproduction capacity of European eel. (Enhancing the biological basis for sustainable fisheries and aquaculture)' (EELREP) under Fifth Framework.

assistant: **Objectives**

The ultimate goal of the project is to stop the decline of the European eel population. For this purpose we need to understand the underlying cause of the decline. In this project we will determine the reproduction capacity of silver eels from different locations and the impact of diseases on their physical fitness. Furthermore we aim to provide management tools allowing the formulation of reliable decisions for eel ecosystems and eel fisheries management. For this we will estimate the capacity of yellow eel to transform into the downstream migratory silver eel ('silvering'). Finally we aim to provide fundamental knowledge on the reproduction process, which is likely to be critical for the recruitment of the species. This knowledge might be used in future studies to develop a procedure for artificial reproduction.Specific Objectives1) The capacity of the silver eel to swim to the spawning grounds will be studied. To that end they need to have an impressive endurance, and the capacity to navigate at 50-200 atm water pressure. Current knowledge suggests that pressure is an important factor because its disturbing effects on biophysical and biochemical processes (10, 39). Previous experiments have shown that the first hours under pressure constitute a critical period during which the mortality could be high (40). This mortality is related to the fish's fitness. However, pressure has also been suggested as stimulus for maturation (10). The relation between swimming fitness and infection will be determined as well as the relation between pressure tolerance and infection.2) Fundamental knowledge will be developed that can be used to estimate the silvering capacity. So far, little is known about morphological and physiological changes coupled to the transition from yellow to si
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Immunogenicity and protective efficacy of intranasal delNS1(H5N1) influenza vaccine'.

assistant: **Concept**

The aim of the project is to characterize replication-deficient pandemic influenza vaccine candidates (H5N1) in clinical and preclinical studies. The replication-deficient vaccine is based on the deletion of the NS1 protein (DelNS1 vaccine).  First, several vaccine candidates will be screened for parameters including antigenic properties, receptor specificity, attenuation and immunogenicity in animal models. Studies on elucidation of mechanisms responsible for protection will comprise parameters of innate an d adaptive immunity.  Several standardized immunological techniques such as hemagglutination inhibition (HI) and ELISA will be used for evaluation of vaccine candidates. In addition, novel sensitive methods based on synthetic sialic receptor analogues will be developed for assessment of the antibody response against the hemagglutinin (HA) and neuraminidase (NA). Protective properties of the vaccine against homologous and heterologous influenza strains will be tested in ferret challenge experiments using dif ferent H5 strains. To close the gap between the ferret model and human studies we will use the macaque model to evaluate the immune response.  These pre-clinical studies will allow the selection of the most potent vaccine candidate, which will be produced according to cGMP guidelines on Vero cells. After toxicological evaluation of the vaccine, clinical phase I/II studies will be performed. If permitted by authorities, a human challenge study using attenuated H5 virus will be carried out. Alternatively, for proof of principle of the delNS technology, an H1-delNS1 vaccine will be produced and used in an H1 challenge study.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Crystalline and vitreous silica films and their interconversion' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Silicon is the most abundant element in the earth’s crust. Its oxide, silica (SiO2) is the basis for most minerals of the earth’s crust, and also for a number of technological applications ranging from window glass, via electronics to catalysis. The structure of crystalline materials such as quartz or silica-based minerals is well understood due to the application of scattering techniques such as x-ray or neutron diffraction, for example, which allow accurate structure determinations. Silica, however, also forms glasses, which are amorphous or vitreous. Its structure is not well understood. In fact, diffraction techniques have only been able to deliver pair correlation functions, which reveal the density of a material around a given atom, but do not allow a detailed reconstruction of the atomic structure as in the case of crystalline materials. Until recently, a real space image of a silica glass with atomic resolution had not been recorded. Using scanning probe techniques applied to a thin silica film grown atomically flat on a metal substrate, it has been possible to reveal, for the first time, an atomically resolved image of vitreous silica. Both, a crystalline as well as a vitreous phase have been imaged. With this system, it is now possible to address the transition from a vitreous state to a crystal-line in real space by developing a scanning probe microscope that allows the study of its structure over a wide range of temperatures ranging from cryogenic temperatures to 1500 K. It is the purpose of this grant application to build such a device and apply it to the crystal-glass transition and the study of vibrational properties. This instrument may also be used to address a number of scientific problems related to other glass-formers, such as borates and the influen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Clinical development of oral oleylphosphocholine as a new drug for the treatment of Old World Cutaneous Leishmaniasis' under Horizon 2020.

assistant: **Concept**

Cutaneous leishmaniasis (CL) is a poverty related, neglected tropical disease, which is without an effective and cheap systemic treatment. The aim of TT4CL is to develop a new orally available drug for treatment of CL aimed towards registration with stringent regulatory authorities. Oleylphosphocholine (OlPC), regarded as a new drug by the FDA, is structurally related to the anti-leishmanial miltefosine. It is being developed as an immediate-release tablet for the treatment of CL and, currently, is the only systemically delivered drug specifically being developed for this indication. OlPC is active in vitro and in vivo against different CL-causing Leishmania parasite species and shows curative advantage over miltefosine in rodent models of leishmaniasis.  The primary objective of this study is to complete the pre-clinical package that is essential for the subsequent clinical development of OlPC. The project will aim to optimize the synthesis and formulation of OlPC, including stability testing that is appropriate for tropical climates. It will include in vitro drug sensitivity analyses in parasites causing CL (Leishmania tropica and L. major) in the Islamic Republic of Iran, with our endemic-country partner.  Comparative studies in animal models with existing anti-leishmanial compounds will establish efficacy advantages and determine pharmacokinetic-pharmacodynamic relationships for OlPC. Phase 1 studies will confirm tolerability and pharmacokinetics of single doses and multiple dosing regimens. Results will be used to guide decisions by future partners on the clinical development of OlPC.  This proposal directly addresses the priorities highlighted in this H2020 call. To our knowledge, we are the only consortium that is implementing this type of approach, and there is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Seismic Risk Reduction and Adaptation for Complex Time-Dependent Industrial Systems' under Horizon Europe.

assistant: **Concept**

Adapting to the increasing threat of natural hazards is one of the most pressing current societal issues. Specifically, seismic risk reduction and adaptation of complex intertwined industrial facilities are keys for an effective EU green transition. Nevertheless, the most common policies still rely only on static risk analyses, neglecting temporal and spatial interactions.In fact, no one has yet tackled the critical aspect of industrial system adaptation, accounting for the dynamics of the hazard, of the system itself and its recovery processes. This comes with no surprises, as system adaptation is a highly complex stochastic process, deeply rooted into the future, where uncertainties at all levels play a crucial role. This critical research gap is filled with the Seismic Risk Reduction and Adaptation for Complex Time-dependent Industrial Systems (REACTIS) project, which is the first integrated uncertainty quantification (UQ)-based methodology that aims to solve these open questions. The project will examine the stochastic dynamics of the performance of industrial facilities subjected to time-variant seismic hazards. In particular, the recovery processes of the systems will be deepened and treated from a UQ and stochastic dynamics perspective.Building upon preliminary collaboration, the project will focus on the stochastic dynamics and recovery of a single 1-node system. Then, a real-world complex industrial case study will be deployed. Leveraging concepts from spatial statistics and graph theory, the intertwined network topology of the industrial system will be mapped. Specifically, the evolution of the dynamics of the system will be extended to a m-nodes, initially deterministic, then random, network configuration. Finally, our research will encompass an in-depth anal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Application of omics-based strategies for improved diagnosis and treatment of endocrine hypertension', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Arterial hypertension affects up to 45% of the general population and is responsible for 7.1 million deaths per year worldwide. Although a large therapeutic arsenal exists, blood pressure control is sub-optimal in up to two thirds of patients. Yet, even small increments in blood pressure are associated with increased cardiovascular risk, with 62% of cerebrovascular disease and 49% of ischemic heart disease being attributable to hypertension. Detection of secondary forms of hypertension is key to targeted management of the underlying disease and prevention of cardiovascular complications. Endocrine forms of hypertension represent major targets for stratified approaches of health promotion. They include a group of adrenal disorders resulting in increased production of hormones affecting blood pressure regulation: primary aldosteronism (PA), pheochromocytoma/functional paraganglioma (PPGL) and Cushing’s syndrome (CS). These diseases are associated with increased cardiovascular and metabolic risk and with diminished quality of life.This project will develop and evaluate an omics-based stratified health promotion program for patients with endocrine forms of hypertension. We will define specific omics profiles for patients with PA, PPGL and CS by integrating high throughput genetics, genomics and metabolomics data with phenome annotations through bioinformatics modelling. Established profiles will be validated as stratification biomarkers and applied to the screening of referred hypertensive patients for both stratifying primary forms of hypertension for effective and cost efficient therapy as well as improving identification of endocrine causes for curative treatment and prevention of cardiovascular and metabolic complications. Omics-based profiling should allow identificati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'International Network on Advanced high energy Permanent Magnets' in the context of a Horizon 2020 call.

assistant: **Objectives**

The main objective of this Marie Curie RISE action is to improve and exchange interdisciplinary knowledge of materials design by modelling, materials synthesis, characterization, and materials processing for permanent magnet development to be able to provide a critical raw free permanent magnet to the industry.  Permanent magnets are indispensable for many commercial and military applications. Major commercial applications include the electric, electronic and automobile industries, communications, information technologies and automatic control engineering.  Development and improvement of new technologies based on permanent magnets requires the joint effort of a multidisciplinary researcher collective, involving the expertise of participants on different disciplines including physics, chemistry, materials science and engineering. A consortium with such expertise is put together to undertake an integrative and concerted effort (via knowledge transfer) to provide the fundamental innovations and breakthroughs that are needed to fabricate/implement industrially new phases and microstructures required for the development and application of advanced permanent magnets without the use of critical materials.Results will be widely disseminated through publications, workshops, post-graduate courses to train new researchers, a dedicated webpage, and visits to companies working in the area. In that way, we will perform an important role in technology transfer between the most advanced hard and soft magnetic materials design and characterisation methods for the development of permanent magnets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated research on DEvelopmental determinants of Aging and Longevity' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

IDEAL will obtain insight into the role of early life conditions affecting late-life health, disease and aging, and the role of epigenetic regulation therein. IDEAL will identify the determinants and targets of this epigenetic regulation utilizing a resource of unique human cohorts and animal studies that allow testing of hypotheses on the link between development and aging.Key objectives of IDEAL are1.Quantify the role of epigenetic regulation in the response to developmental conditions that affect growth & metabolism, immunity, and reproduction in animal models and its translation to human conditions.2.Quantify the role of epigenetic regulation in the response to developmental conditions of humans and create the animal model that resembles such responses.3.Create a reference library of gene expression and epigenetic changes as a function of age and obtain insight into principles of epigenetic regulation across species.4.Develop monitoring tools of epigenetic effects following developmental conditions.5.Develop monitoring tools of epigenetic control during aging and their meaning for physiological functions, and for the development of biomarkers of aging6.Identify pathways determining and promoting human longevity.7.Identify pathways determining human health and longevity by influencing developmental processes.8.Develop animal models for testing relevant compounds to modify epigenetic effects early or later in life.We will study known longevity determinants as well as newly discovered pathways, and we will link early development with all adult phases. Our research can provide models for testing interventions through epigenetic regulation that improves healthy aging and longevity and that can be translated into novel drug targets and protein therapeutics. IDEAL integrat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Evaluation of metastatic and angiogenic potential of cancer stem-like cells in distinct mouse models for lung and liver metastasis' (Metastasis) targeting Seventh Framework.

assistant: **Abstract**

Metastasis disease is the leading cause of cancer-related mortality with very few effective treatment options available for patients.  Metastases are characterized by the presence of vascular proliferation, a subpopulation of stem-like cells and infiltration by various bone marrow derive cells (BMDCs).  BMDCs have been shown to provide the premetastatic niches that promote the angiogenic process and create an environment permissive for tumor cell homing and colonization.  The cancer stem cell (CSC) theory defines a subset of cancer cells with the exclusive ability to drive the growth and spread of a tumor. This research proposal is founded on the hypothesis that the CSC theory also applies to the metastasic process.  The aims are to determine the relative contribution of CSCs to tumor cell homing, their ability to recruit BMDCs and induce angiogenesis. The final goals are to elucidate the mechanisms that participate in these phenomena and to develop novel therapeutic strategies to overcome metastasis initiation and progression.Briefly, using well-defined models of lung and liver metastasis, we will 1- determine if CSCs are more metastatic and angiogenic than non-CSCs; 2- identify the genes responsible for the metastatic and angiogenic capacity; 3- characterize the role of CSCs in the recruitment of BMDC; 4- examine whether cancer cells secrete factors that directly activate myeloid cells to produce tumor-promoting cytokines; 5- quantify the number of CSCs in samples from patients with lung and liver metastasis and validate their metastatic potential.