RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Chromatin Fiber and Remodeling Factor Structural Studies' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

DNA in higher organisms is organized in a nucleoprotein complex called chromatin. The structure of chromatin is responsible for compacting DNA to fit within the nucleus and for governing its access in nuclear processes. Epigenetic information is encoded chiefly via chromatin modifications. Readout of the genetic code depends on chromatin remodeling, a process actively altering chromatin structure. An understanding of the hierarchical structure of chromatin and of structurally based, remodeling mechanisms will have enormous impact for developments in medicine.Following our high resolution structure of the nucleosome core particle, the fundamental repeating unit of chromatin, we have endeavored to determine the structure of the chromatin fiber. We showed with our X-ray structure of a tetranucleosome how nucleosomes could be organized in the fiber. Further progress has been limited by structural polymorphism and crystal disorder, but new evidence on the in vivo spacing of nucleosomes in chromatin should stimulate more advances. Part A of this application describes how we would apply these new findings to our cryo-electron microscopy study of the chromatin fiber and to our crystallographic study of a tetranucleosome containing linker histone.Recently, my laboratory succeeded in providing the first structurally based mechanism for nucleosome spacing by a chromatin remodeling factor. We combined the X-ray structure of ISW1a(ATPase) bound to DNA with cryo-EM structures of the factor bound to two different nucleosomes to build a model showing how this remodeler uses a dinucleosome, not a mononucleosome, as its substrate. Our results from a functional assay using ISW1a further justified this model. Part B of this application describes how we would proceed to the relevant cryo-E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Understanding the functional role of Retinoic Acid Receptor Beta2 in the development of oral cancer'.

assistant: **Objectives**

The most common cancer in India is oral squamous cell carcinoma (OSCC), a tumour with poor survival whose incidence has also markedly increased in the UK over the past 30 years.  There has been much interest in chemoprevention of OSCC, but large clinical trials of agents such as Vitamin A analogues (retinoids) have proved disappointing.  One reason is that the function of retinoids in precancerous/cancerous oral tissues is poorly understood and this is a hindrance to individualisation of therapy.  It is known that expression of the retinoid receptor RARbeta2 is lost as OSCC develops and we have compelling evidence that this is due to a novel role in replicative senescence, an in-built cell division limit, which functions as an anticancer system.  We have a unique panel of cells from all stages of OSCC development, some which undergo replicative senescence and others which are immortal. These cells differ in their expression of RARbeta2 and are the ideal system in which to investigate the function of this receptor.   We will manipulate expression of RARbeta2 in these cells and assess the effects on senescence, proliferation, apoptosis and differentiation and generate a transcriptional network.  To assess these changes in a more physiological environment we will label these manipulated cells and use them in to construct tissue engineered oral mucosa, with real time quantification of the effects of retinoids and alterations in receptor expression.  We will compare these results with the pattern of RARbeta2 expression in a panel of precancerous oral lesions which may allow us to identify retinoid-sensitive lesions which are amenable to retinoid therapy.  This is a timely and exciting project at the basic science/clinical interface, bringing together a rising star of Indian
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A locus on mouse chromosome 14 controls plasma plant sterol levels and cholesterol absorption' to be submitted under Sixth Framework.

assistant: **Abstract**

The absorption of cholesterol from the intestine plays an important role in determining the plasma level of cholesterol, a well-established risk factor for atherosclerosis cardiovascular diseases. Nevertheless, the molecular basis of the absorption process and its regulation are largely unknown. We identified two inbred mouse strains, C57BL/6J and castaneus (CASA/Rk), that differ in cholesterol absorption and plasma plant sterol levels, a surrogate measure of cholesterol absorption from the intestine. An inter-cross between these strains revealed a plasma plant sterol locus on chromosome 14, which peaked at 17cM with a maximum LOD score of 9.9. Construction and studies in one chromosome 14 congenic strain, designated 14DKK, with 40.5cM of CASA/Rk interval introgressed onto the C57BL/6J background confirmed the effect of this locus on plasma plant sterol levels and cholesterol absorption. Moreover, studies in 14DKK animals disclosed a modified ileum-liver signalling pathway that affects bile acid metabolism and is likely to explain the effect of this locus.The main purpose of this grant proposal is to discover the culprit gene(s) at the 14DKK interval that modify plasma plant sterol levels and cholesterol absorption. To achieve this goal we will fine-map causative genes through construction of sub-congenic mouse strains, apply high throughput expression studies, sequence genes in our interval and test the effect of candidate genes through over-expression and knockdown in cell cultures. The discovery of these genes may lead to the development of novel genetic markers of susceptibility to hyper-cholesterolemia and new targets for therapy of dyslipidemic states and coronary heart disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cascading impacts of predator biodiversity loss: development of a predictive framework' to be submitted under Seventh Framework.

assistant: **Abstract**

Predator species are disproportionately vulnerable to human-caused extinction and their loss can trigger ecosystem altering trophic cascades. Elucidation of the consequences of predator biodiversity loss is therefore central to forecasting how ecosystems will respond to real-world losses of biodiversity. Experiments to date reveal a high degree of variability around effects of predator species losses, leading to high uncertainty of predictions. The Aim of the project proposed here is to develop a predictive understanding of the cascading effects of predator species loss. Two key sources of variability in effects of predator species loss are hypothesized, both based on the functional traits of predators. An experimental approach is proposed involving an international network of collaborators to identify key functional traits underlying the direct and interactive effects of multiple predators on their prey and ecosystem functioning . Once identified, key traits of predators will be challenged to explain and predict the effects of predator species loss in novel contexts and across different systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Anthrax Environmental Decontamination Network' (AEDNET) targeting Seventh Framework.

assistant: **Abstract**

Anthrax, caused by the spore forming bacterium Bacillus anthracis, is  a disease of animals which can infect humans either directly through contact with infected animals  or indirectly as a consequence of bioterrorism.  In regions of the world such as  Eastern Europe and Central Asia the pathogen still constitutes a significant threat to human and animal health. A lack of effective veterinary facilities, access to  vaccines and the burial of  untreated infected animals has resulted in the contamination of large areas due to the ability of the spores  to survive in soil for many years.  Given that the  bacteria is non-contagious its elimination  from contaminated soil and surfaces would have a major impact on disease incidence.   We are seeking to to develop an approach which is specific for B.anthracis and will have minimal impact on the environment.  Following preliminary field trails on animal burial sites in Turkey we have  developed a technique whch triggers the conversion (germination) of  B.anthracis spores into bacteriophage (phage) susceptible vegetative bacteria.  Phages are  natural preditors of bacteria, are species specific and found in close proximity to their prey.  We hypothesize  that a  combination of germinants and B.anthracis specific phages will be an effective and ecologically friends means of reducing spore numbers. Indeed in laboratory studies we have demonstrated the feasibility of this approach.  Additional  phages have been isolated from burial sites in Georgia and Turkey and will be evaluated as part of this study.  While there are a  number of  funded phage based anthrax decon projects in the region  their is as yet no dedicated scientific network to facilitate the sharing of best practices and to link researchers in neighbouring countries fa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Labour Skills from Occupations: Quantifying Human Capital before and during the Industrial Revolution' (QHC) targeting Seventh Framework.

assistant: **Abstract**

Most economic growth theorists see human capital input as a key factor in long-term economic development. Little is known, however, about the role of human capital in the historical process of industrialization of Western Europe. Recent empirical attempts to identify human capital in the past face the problem that human capital is difficult to quantify, particularly before public schools become widespread. Existing measures of human capital in preindustrial Europe (notably literacy rates, numeracy rates and number of apprenticeships) suffer from the drawbacks that they either identify only very basic skills (as in the case of numeracy and literacy) or that they cover only a modest and biased fraction of the population (as in the case of apprenticeships). More importantly, all of them are subject to the criticism that not all the skills acquired by workers were necessarily used in their productive activities.The present study offers a new approach to measuring human capital used in productive activities based on historical occupational titles. The methodology relies on a well-established classification of historical occupations known as the HISCO system. The HISCO system categorizes tens of thousands of occupational titles from countries and languages all around the world from the sixteenth to the twentieth century. In combination with the HISCLASS system, which maps occupational titles into skill-levels used in order to conduct the work described by the occupational title, it is possible to subdivide occupations according to four degrees of working competences depending on the level of ability required to perform the work, namely higher-skilled, medium-skilled, lower-skilled and unskilled occupations. By assigning a score to each of the four skill-levels, it is then pos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Open Access Single entry point for scale-up of Innovative Smart lightweight composite materials and components' (OASIS).

assistant: **Innovation**

The OASIS project aims at fulfilling market potential of nano-enabled multifunctional lightweight composites, particularly of polymer-matrix and aluminium composites. The OASIS gathers manufacturing capacity of 12 pilot lines for the industrial production of nanoscale structures in unprocessed form, intermediate products with nanoscale features and nano-enabled products as well as other complementary technical (modeling, characterization, toxicology, life cycle assessment) and non-technical services (Business innovation coaching, business planning, access to private capital). These modular services will be provided to companies, particularly to SMEs, to gain access to unique facilities and knowledge without high capital investment. Such support is particularly needed at the crossroads between three KETs (nanotechnologies, advanced materials and advanced manufacturing and processes) and in era of multifunctional products when wide scope of know-how is needed for pre-production or industrial low-medium volume production.The companies will access these wide offering infrastructures by a single-entry point, which will ensure quality customer relationship and management from request formalization to delivery.The multi-pilot line manufacturing capacity of OASIS will be validated by 6 industrial showcases, where lightweight products (TRL6-7) ensure significant impact in construction, automotive, energy and aeronautic industries. The complete OASIS services to SMEs will be demonstrated by 6-12 democases, which will be selected from identified and potential clients by an open call, to ensure highest possible impact. The OASIS will set up economically sustainable open innovation structure, leveraging the previous investments for the full benefit of European companies introducing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mobile Vapour detection and identification of Synthetic drugs' (PENTION) under Horizon Europe.

assistant: **Objectives**

Drug production and trafficking is a major societal challenge globally, with a high focus on the EU. The drug trade wreaks devastation throughout its value chain: from overwhelmed government administrations, to violence and brutality of the drug cartels, to citizens who succumb to addiction or fatal overdoses. On top of that, we now need to deal with a quickly evolving and very dangerous situation: the proliferation of synthetic drugs, including new psychoactive substances (NPS), which represent a real threat to society, causing serious cross-border threats to health. Synthetic drugs have already changed the traditional drug production and supply model to the extent that traditional seizing methods do not work efficiently and as effectively anymore. This situation forces the authorities to develop and implement new strategies to combat their trade which is based on the importation of chemical precursors from Eastern countries with local production, highly concentrated in different EU areas, such as the case of the Limburg Region (The Netherlands). In addition to such new strategies, novel technologies, with better performances are required for the detection, specifically in terms of sensitivity, selectivity, versatility, portability and wider databases; this is the objective of the PENTION project which aims to develop a new vapour detector that relies on a very innovative concept of a differential mobility analyzer (DMA), which classifies molecular ions based on their electrical mobility, followed by mass spectrometry analysis. This analysis generates a chemical fingerprint of the samples, and after the processing with intelligent detection routines, it becomes possible to accurately classify and detect new drugs and precursors, as well as potential manufacturing sourc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A new portable diagnostic and operating ophtalmic microscope' in the context of a Fourth Framework call.

assistant: **Objectives**

During the past ten years there has been a technical revolution in eye surgery in developed countries Due to the lack of a portable operating and diagnostic microscope many of these developments can only be utilised in Teaching Hospitals in the West and not at all in the Developing World. More than 35 million people in the world suffer from operable blindness. Despite the efforts of man excellent charities it is impossible to keep up with new cases of blindness, and the backlog remains. One major cause is the lack of portable operating and diagnostic microscopes. Also in most developed countries there is pressure on ophthalmic surgeons to provide day case cataract surgery in outreach clinics, but the lack of such a machine imposes restrictions. It is only major centres in the West and some university and private units elsewhere, which can enjoy the benefits of small incision surgery. Consequently surgery taking place away from these centres has to rely on more traditional large incision E CCE and ICCE techniques. The current instrumentation has several basic limit ations for general usage: 1. No integrated operating and diagnostic system available 2. Current systems due to size and weight require fixed operating cent res 3. High costs ($30,000+) restrict use to major centres 4. Current product s use bespoke optics which are heavy and expensive 5. Current lack of automatic focusing creates need for heavy and cumbersome foot pedalsystems. 6. Diagnostic requirements need several different magnification devices. Thus the project will focus on the development of individual lightweight and inexpensive components, each being approved in clinical trials, and in conclusion developing an integrated lowcost complete system. To achieve these ends requires a close International liai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Distinguishability and the physics of quantum information' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Distinguishability and the Physics of Quantum Information The aim of the research project proposed herein lies in the application of recent quantum-information approaches concerning the characterisation of wave-particle Duality in two-way interferometers, in order to design new devices for the quantum processing of information. We consider a pair of two-way interferometers coupled by a dispersive interaction at their central stage. At the point of maximum entanglement, the fringe visibility of both interferometers are totally degraded, demonstrating quantum-information-based wave-particle Duality. We have also shown in a preliminary theoretical calculation that the perfect correlations established at this point enables Bell-state engineering and, in addition, can be used for the design of a quantum controlled-NOT gate. We plan to develop a full characterisation of this multi task device, according to quantum Information Theory. Special attention has to be paid to practical implementation factors, such as decoherence, which could limit the performance of this device. The goals of the project can be linked with the aims of the European Research Network The Physics of Quantum Information.