RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Bristol environmental atmospheric chemistry' to be submitted under Sixth Framework.

assistant: **Abstract**

Air quality and climate change are two of the most pressing environmental challenges facing us in the 21st Century. The vast majority of the population of Europe live within or near to an urban conurbation and are subject to the resultant air pollution, wi ll-implications for the health of humans, animals and plants. Release and chemical degradation of pollutants from urban and industrial centres, as well as from biomass and fossil fuel burning, contributes significantly to the atmospheric loading of so-call ed greenhouse gases, and hence to climate change. The pressing importance of an improved understanding of the atmospheric chemistry, photochemistry and dispersal of various organic pollutants is the motivation for this project to establish an Early Stage R esearch Training programme at the University of Bristol. The research programme addresses: ¿ Atmospheric modelling, including regional scale modelling of air quality; ¿ Experimental studies of heterogeneous processes at aerosol surfaces and condensed phase chemistry within aerosoldroplets; ¿ Experimental and theoretical studies of molecular and radical photochemical and reaction mechanisms; ¿ Development of new analytical instrumentation for monitoring of trace atmospheric constituents; ¿ Deployment of such novel instruments for in situ measurements of concentrations and dispersal of pollutants; ¿ Assessing the impact of air quality on public health. These six projects involve novel scientific research at the forefront of atmospheric science using state-of-t he-art instrumentation and computational methods, supported by the world-class resources of the Bristol department. The results from these projects will be fed into relevant policy making units in the UK and the rest of Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Modulation of neocortical microcircuits for attention'.

assistant: **Innovation**

At every moment in time, the brain receives a vast amount of sensory information about the environment. This makes attention, the process by which we select currently relevant stimuli for processing and ignore irrelevant input, a fundamentally important brain function. Studies in primates have yielded a detailed description of how attention to a stimulus modifies the responses of neuronal ensembles in visual cortex, but how this modulation is produced mechanistically in the circuit is not well understood. Neuronal circuits comprise a large variety of neuron types, and to gain mechanistic insights, and to treat specific diseases of the nervous system, it is crucial to characterize the contribution of different identified cell types to information processing. Inhibition supplied by a small yet highly diverse set of interneurons controls all aspects of cortical function, and the central hypothesis of this proposal is that differential modulation of genetically-defined interneuron types is a key mechanism of attention in visual cortex. To identify the interneuron types underlying attentional modulation and to investigate how this, in turn, affects computations in the circuit we will use an innovative multidisciplinary approach combining genetic targeting in mice with cutting-edge in vivo 2-photon microscopy-based recordings and selective optogenetic manipulation of activity. Importantly, a key set of experiments will test whether the observed neuronal mechanisms are causally involved in attention at the level of behavior, the ultimate readout of the computations we are interested in. The expected results will provide a detailed, mechanistic dissection of the neuronal basis of attention. Beyond attention, selection of different functional states of the same hard-wired circui
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Bose-Einstein condensated atoms into a high finesse optical cavity.'.

assistant: **Objectives**

The proposed project will enter a novel physical regime which becomes accessible when a Bose-Einstein condensate (BEC) is placed inside a high finesse optical cavity. On the one hand, the BEC allows the creation of well controlled few atom samples and of mean field dominated many-body systems. On the other hand, high finesse cavities, which have been so far been used in the field of quantum electrodynamics (QED), offer the possibility of single atom detection and of atom-photon entanglement.   In a first experimental step it is planned to measure the arrival time statistics of atoms extracted from a BEC, thereby giving access to the intensity correlations of an atom laser. The next experimental challenge will be to bring the condensate into the optical cavity. A moving optical lattice, created by phase controlled counter propagating lasers, will act as a conveyor belt for the atoms. The condensate will then be used as a zero temperature thermal bath to constantly cool one or few atoms in a different internal state. These can be manipulated with methods of QED. Entangled states between several atoms or atoms and photons can be engineered. Cavity QED in this regime is as yet unexplored and will give access to questions of decoherence, which is crucial for quantum information processing with neutral atoms. In particular, we plan to entangle internal states of two atoms, forming a non-classical state which is expected to be long lived in this environment.   The project stands at the border line of two quickly developing domains, dilute quantum gases and quantum information processing. These two domains recently show a convergence and training a researcher with such a dual experience is certainly of interest for the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Adaptive services grid' (ASG).

assistant: **Concept**

The goal of Adaptive Services Grid (ASG) is to develop an open development platform for adaptive services discovery, creation, composition, and enactment. To achieve its goal, ASG addresses scientific and technological issues making use of the knowledge and expertise of major European research institutions with significant contributions from the software, telecommunications, and telematics industry. ASG provides the integration of these related sub-projects in the context of an open development platform, including tool development by small and medium sized enterprises.ASG will allow companies to register services they provide through standardized interfaces. Based on semantic specifications of requested services by service customers, ASG discovers appropriate services, composes complex process services and if required generates software to create new application services on demand. Subsequently, application services will be provided through the underlying computational grid infrastructure based on adaptive process enactment technology. In the proposed project, methods and concepts from software architectures, software development methodologies, Web services composition and workflow process planning and coordination will be complemented by recent results in domain engineering, software generation and Semantic web and agent negotiation research.Impact on a European level is achieved by strong industry involvement both with respect to platform development, deployment, and exploitation in the areas of telecommunications and telematics. To this end, ASG makes a difference for the people in the Society since it helps bridging the gap between member states and important candidate states in the areas of telecommunications and telematics. On the exploitation side, the developmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Hybrid Fixed Leading Edge'.

assistant: **Concept**

The proposal is adressing the topic JTI-CS2-2016-CFP03-LPA01-14 Automated injection RTM system process based on innovative sensor technologies in a low cost smart manufacturing tooling prototype and any tooling involved in the manufacture or the validation of the structure.The final objective of this topic is to produce the needed tooling to manufacture the HTP Leading edge structure (modified to include a HLFC system) using liquid resin injection processes, in particular RTM process to produce the mentioned part. The resulting structure shall comply with the actual regulation of the aerospace sector, in particular regarding geometrical tolerances and defects. Coexpair is the leader of this project, the other partners are Tecnalia, Pégard Productics and University of Liège. In order to produce the needed tooling to manufacture the HTP Leading edge structure, 5 elementary technology blocs are defined as objectives : 1°) low cost/ natural materials employed in the tooling manufactured, 2°) eco-design for of the tooling manufactured, 3°) energy savings during the manufacture processes of the future parts, 4°) manufacturing processes simplification in order to improve the repetitiveness of the process, 5°) production time savings to reduce the cost and production lead times. A “quick” specimen was manufactured prior to project submission to show the RTM process is suitable for the project. The project focuses on the automation of manufacturing steps of RTM process, including ply cutting and mold cleaning. Elementary tests of a few key points of the automation will be performed in industrial environment (Coexpair shop). In order to optimize floor shop organization, work flow simulation will be performed. In addition to Coexpair experience on RTM process and mold design, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Chronic inflammation leading to scarring, the major mechanism for kidney failure' in the context of a Fourth Framework call.

assistant: **Objectives**

Objectives: The aim of the present application is to develop a European collaborative research programme to study pathogenesis of progressive kidney failure. The purpose will be use the insights gained to define specific targets for therapeutic intervention, and to identify markers for disease activity suitable for use as surrogate end points in clinical trials.Brief description: Throughout Europe well over 250,000 people with chronic renal failure are being treated by dialysis and renal transplantation. The human and economic burden of chronic renal disease is already enormous and the number of patients requiring this treatment for end stage renal failure is increasing by 10-15 % per year as new patients are added to the program. The most common causes of chronic renal failure include vascular disease, autoimmune diseases such as diabetes and glomerulonephritis, and chronic bacterial and viral infections. They progress to the end stage over many years despite treatment which is generally ineffective.Current treatments for progressive chronic renal disease have been developed empirically, based on the results from randomised controlled clinical trials. These take many years to complete and involve major investment in finances and personnel. Thus far, treatments developed in this way have been non-specific and largely ineffective. In order to develop rational and specific approaches to treatment we need to know more about the mediators that control chronic inflammation and scarring in the kidney. Studies of clinical and experimental renal disease combined with results for in vitro experiments provide a compelling case that a common underlying pathogenesis, independent of the original cause or renal injury, leads to progressive renal scarring and renal failure. An insight
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Pushing Myc inhibition towards the clinic'.

assistant: **Innovation**

Deregulation of the Myc oncogene promotes tumorigenesis in most if not all cancers and is often associated with poor prognosis. However, targeting Myc has long been considered impossible because of potential catastrophic side effects in normal tissues. Despite this general assumption, we showed that Myc inhibition displays extraordinary therapeutic benefit in various transgenic mouse models of cancer, and caused only mild, well-tolerated and reversible side effects in normal tissues. For these studies we have employed a dominant negative of Myc, called Omomyc, which we designed and validated, and that is able to inhibit Myc transactivation function both in vitro and in vivo. Omomyc has so far been utilized exclusively as gene therapy and served the purpose of pre-clinically validating the therapeutic impact of systemic Myc inhibition. In this proposal we intend to push such a therapeutic approach further towards the clinic, making use of1. Omomyc-based Cell Penetrating Peptides (CPPs): a novel, state-of-the-art potential method for directly utilising Omomyc itself (or a similar peptide) as a drug;2. A new generation of Myc inhibitory small molecules generated by our collaborators at the Roswell Park Cancer Center.Our study in different mouse models of cancer will provide a comprehensive preclinical validation of such innovative therapies and will potentially boost our therapeutic arsenal against the majority of human cancers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Autonomous light intervention vehicle' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

ALIVe project proposes to demonstrate the feasibility of navigating and docking a free underwater vehicle, autonomous in energy and supervised by an acoustic modem, and to dock it on an underwater fixed structure to carry out inspection and maintenance tasks. Unlike conventional Autonomous Underwater Vehicles, this vehicle will feature station keeping, auto docking and manipulation capability. Its applications are: inspection and maintenance of underwater facilities (oil & gas, scientific), assistance in rescue operations, archaeological missions, hazardous materials collection (radio-active wastes, chemical weapons) and any type of intervention where a light vehicle, cost effective and easy to mobilise, can replace an ROV.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Coordination Of Patterning And Growth In The Spinal Cord' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Individuals of the same species vary widely in size, but their organs have reproducible proportions and patterns of cell types. How cell fate specification and tissue growth are coordinated during embryonic development to achieve this reproducibility is a fundamental question in biology. Yet, surprisingly little is known about the underlying mechanisms. A major challenge has been to obtain the quantitative data required to assess the dynamics and variability in growth, pattern and signalling by morphogens – molecules that regulate both cell fate specification and tissue growth. I recently established experimental and theoretical approaches that allowed me to reconstruct with unprecedented resolution the three-dimensional growth and pattern of mouse and chick spinal cord. My data revealed a previously unanticipated role of tissue growth dynamics in controlling pattern reproducibility. This quantitative framework provides an exciting opportunity to elucidate the biophysical and molecular mechanisms of growth and pattern coordination. I will use this unique position to understand: 1) how signalling by multiple morphogens is integrated to control pattern, 2) how morphogens control cell cycle kinetics, 3) how morphogen source and target tissue are coupled to achieve pattern reproducibility. To address these issues, I will build on my experience with quantitative analyses to design novel assays where signalling, cell cycle dynamics and transcriptomes can be precisely measured and manipulated with single cell resolution. I will exploit state-of-the-art genome editing techniques to uncouple the critical feedback links and gain a novel perspective on pattern reproducibility and morphogen function. The project will advance our fundamental understanding of tissue morphogenesis and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Ocean Cryosphere Exchanges in ANtarctica: Impacts on Climate and the Earth system'.

assistant: **Concept**

OCEAN:ICE will assess the impacts of key Antarctic Ice Sheet and Southern Ocean processes on Planet Earth, via their influence on sea level rise, deep water formation, ocean circulation and climate. An innovative and ambitious combination of observations and numerical models, including coupled ice sheet-climate model development, will be used to improve predictions of how changes in the Antarctic and Greenland ice sheets impact global climate. It will make new circumpolar and Atlantic observations in observational gaps. It will  assimilate these and existing data into improved ice sheet boundary conditions and forcing, producing new estimates of ice sheet melt and impacts on ocean circulation, including the Atlantic Meridional Overturning circulation. It will develop, calibrate and assess models used to predict the future evolution of the giant ice sheets. It will reduce the deep uncertainty in the impact of their melt on societally relevant environmental changes on decadal to multi-centennial time scales. OCEAN:ICE will assess the potential for passing ice sheet 'tipping points' and their consequences for ocean circulation and climate.  OCEAN:ICE will raise the profile of European research through its extensive network of international collaborators, who provide scientific and logistical support.  It will directly contribute to the All-Atlantic Ocean Research Alliance through observations, logistical collaboration and analysis. It will significantly advance the state-of-the-art in coupled ice sheet-climate modelling and directly contribute to international climate assessments such as the Intergovernmental Panel on Climate Change and World Ocean Assessment. It will link organically to European data centres to disseminate its data, following FAIR and INSPIRE principles.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Studies of ozone distributions based on assimilated satellite measurements' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The global ozone distribution has changed considerably over the last decade. Record low global ozone levels have been observed in the last few years with downward trends over much of the globe (WMO 1995). The analysis of changes in the ozone fields has been severely hampered by a lack of consistent data sets. This analysis is particularly important when determining the relative roles of chemistry and dynamics in the observed changes in ozone. The main goal of this project is to develop the technique of data assimilation to generate a data base with a consistent description of the dynamics and the ozone distribution in the atmosphere. This will be a prime example of a value-added product derived from satellite data. For this purpose we will build an infrastructure for handling real-time ozone data. The data base will be of considerable value for the documentation of the climatology of ozone, for the interpretation of the chemical data from research satellites, and for the development of policy. Data assimilation is a methodology used successfully in the field of numerical weather prediction to derive, from a limited set of observations, a good, consistent description of the state of the atmosphere. This is a prerequisite for a successful weather forecast. The atmospheric ozone distribution shows strong fluctuations related to weather systems. The proposed four-dimensional variational data assimilation will make it possible to derive information about the dynamical state of the atmosphere from the ozone observations. This will lead to an improved description of the state of the atmosphere. We expect that ozone observations from a variety of satellite instruments will become availahle in the near future. An ozone data assimilation procedure provides a wealth of statistics