RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Light, easy to Cut and moisture proof façade Wallboard' (CUTEWALL).

assistant: **Innovation**

The construction sector employs directly 11.8 million people and is EU's largest industrial employer accounting for 7% of total employment in EU. About 910 billion Euro was invested in construction in 2003, representing 10% of the GDP. The construction sector is characterised by a large number of small enterprises, and relatively few large ones, with most enterprises serving a relatively small geographical market. When constructing blocks of flats the framework consist of a concrete skeleton making up the floors, ceilings, and transversal interior walls of the building. It is important to cover the facades as soon as possible so the building can dry properly and protect the interior from rain. Façade covers are traditionally temporary structures such as e.g. plastic covers supported by light wood or steel beams or permanent structures of wooden beams and gypsum. The temporary structures create a considerable amount of waste whilst the plaster and wood beams soak water that may give grounds for fungus and mould. Our idea is to develop a custom size, prefabricated façade wallboard to form part of the permanent construction based on water repellent closed cell polyurethane foam and construction waste as reinforcement. The wallboard will be up to 3 by 7.5 meter so no joints will be needed and light enough to be easily mounted using a lift and no scaffolds. The polyurethane foam has good insulation capabilities and combined with construction waste granulates as well as a geodesic net for reinforcement will provide the sufficient mechanical strength. Using waste as filler helps the construction industry to reduce the waste that normally would go to landfill. The product must be easy cut on the site to facilitate door and window assembly that often change from initial plans. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Cold Atom Rubidium Interferometer in Orbit for Quantum Accelerometry – Pathfinder Mission Preparation'.

assistant: **Innovation**

The overarching goal of CARIOQA-PMP is to prepare the deployment of quantum gravimeters/accelerometers in space, within the decade, through a Quantum Pathfinder Mission. Indeed, the emergence of quantum sensors offers an opportunity to provide new applications for climate sciences through the improvement of space gravimetry performance. Hence, the mastery of this technology in space is one of the major environmental, technological and strategic challenges of the decade. Three main objectives have been set for the scope and duration of CARIOQA-PMP:1. To develop an Engineering Model (EM) of the mission’s instrument and to increase the TRL of the critical subsystems up to 5. Complementary EU industrial partners develop the subsystems of the instrument (i.e. Physics Package, Laser System, Microwave Source and Ground Support Equipment) and increase its TRL by assessing the critical technologies in relevant environments. Excellent institutes bring their quantum expertise for the definition of the EM and the mastering of its performance2. To guarantee the adequacy of the hardware development with the future scientific needs. Through their knowledge of scientific applications, leading institutes in geodesy analyse and simulate potential mission scenarios for the Quantum Pathfinder Mission and future Post-Pathfinder scientific missions3. To establish a technical and programmatic roadmap for Quantum Space Gravimetry Missions. This roadmap will be shared and validated by European stakeholders. It ensures the impact maximisation of the project’s results through its harmonisation with the European programmatic frameworkCARIOQA-PMP brings together the main players of quantum sensors in Europe. It gathers unique skills among 16 partners from 5 EU Member States including 2 space agenci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Description of information transfer across macromolecules by concerted conformational changes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Signal transduction in biology relies on the transfer of information across biomolecules by concerted conformational changes that cannot currently be characterized experimentally at high resolution. In CONCERT we will develop a method based on the use of nuclear magnetic resonance spectroscopy in solution that will provide very detailed descriptions of such changes by using the information about structural heterogeneity contained in a parameter that is exquisitely sensitive to molecular shape called residual dipolar coupling measured in steric alignment.  To show how this new method will allow the study of information transfer we will determine conformational ensembles that will report on the intra and inter-domain concerted conformational changes that activate the androgen receptor, a large allosteric multi-domain protein that regulates the male phenotype and is a therapeutic target for castration resistant prostate cancer, the condition suffered by prostate cancer patients that have become refractory to hormone therapy, the first line of treatment for this disease. To complement the structural information obtained by nuclear magnetic resonance and, especially, measure the rate of information transfer across the androgen receptor we will carry out in a collaborative fashion high precision single molecule Förster resonance energy transfer and fluorescence correlation spectroscopy experiments on AR constructs labelled with fluorescent dyes. In summary we will develop a method that will make it possible to describe some of the most fascinating biological phenomena, such as allostery and signal transduction, and will, in the long term, be an instrument for the discovery of drugs to treat castration resistant prostate cancer, a late stage of prostate cancer that is incurabl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Agency in Law' (LEGACY), addressing dissemination and exploitation.

assistant: **Impact**

The distinction between agents and non-agents is central in law: only agents can decide about their affairs, enter contracts or be held responsible for their actions. Western law has since the 19th century relied on an understanding of agency that has developed in the liberal tradition of thought. According to this Liberal Agency, agents are highly rational human individuals. Persons with cognitive disabilities, artificial intelligences, and nonhuman animals are therefore not agents because of their lack of rationality or humanity. This view of agency is deeply embedded in Western legal systems.Liberal Agency has recently come under increasing criticism and challenges. Many now argue that persons with disabilities, artificial intelligences and/or nonhuman animals could in fact be treated as agents. However, these criticisms have been narrow in scope, and the debate is overall highly fragmented.LEGACY, situated within legal philosophy and history, will offer a comprehensive reappraisal of legal agency. It will investigate three main questions: First, how did Liberal Agency become the dominant understanding of agency in law? Second, what challenges confront Liberal Agency today? And finally, what kind of a theory can best explain the evolving notion of agency in law?The objectives of the project are to deliver:(1) a systematic understanding of the historical background and context of Liberal Agency, its spread in Western legal thought, and its challengers;(2) an in-depth analysis of contemporary agency accounts that incorporates and conceptualizes the historical insights with a systematic understanding of the contemporary debates; and(3) a theory of agency that provides an overall synthesis of the accounts and can explain, reconcile and/or solve the outlined contemporary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Direct conversion hybrid-organic X-ray detectors on metal oxide backplane' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

DiCoMo aims to improve the specificity and sensitivity of flat panel X-ray detectors. This is achieved by a disruptive approach in sensing where we combine radical innovations from leading European players from various disciplines. On the backplane level a new material system enables the realization of an active pixel architecture with amorphous semiconductors. In combination with a custom made read-out IC this promises a significant enhancement in sensitivity. On the frontplane level a novel solvent-free processing technology for hybrid-organic semiconductors is used in conjunction with hybrid-organic core-shell structures to realize thick photodetectors with integrated scintillator particles for minimal optical cross-talk and enhanced resolution.We expect that the results of DiCoMo secure the leading position and strengthen the global competitiveness of European industry in the field of medical imaging. It helps to establish a network between leading players in the field, covering the entire value chain from material provider to system integrator, and enhance the innovation capacity by mutually-profitable alignment of different technologies and IP blocks available to the consortium. Further it advances the safety of environment and health by establishment of a new solvent-free manufacturing process for large area hybrid-organic electronics and provides an opportunity for better diagnosis at lower dose and cost in radiography and mammography.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Histone acetyl-transferases and deacetylases : new target for cancer therapy', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The balance between cell proliferation and differentiation, which deregulation is central to carcinogenesis, is controlled through the interactions between key proteins. These proteins are sensitive to gain-of-function or loss-of-function mutations in cancer, and thus represent potential targets for cancer therapy. Recent basic advances on cell-fate controlling regulatory pathways have demonstrated a key role for histone acetyl-transferases (HATs) and histone deacetylases (HDs).The objectives are:1- to further characterise, at the molecular level, regulatory pathways involving HATs / HDs in normal cells;2- to analyse HATs / HDs in cancer cells;3- to demonstrate that restoring normal function of these enzymes in cancer cells, by modifying their interaction with other proteins, reverses the phenotype.After completion of these steps, drug screening will be set up to reveal new drugs directed against these enzymes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Interstellar Chiral Evolution‒Exploring Enantiomeric Excesses in Evolving Environments' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The origin of life is a profound and experimentally challenging question, with an inherent bias for handed molecules at a chemical level. Homochirality, specifically the preference for left-handed (L-) amino acids in Earth's life, has inspired numerous studies. Meteorite samples provide evidence that this bias originated long before Earth's formation, tied to water-rich interstellar ices and circularly polarized starlight. Yet, we still lack a complete understanding of the chiral photon interaction with organic molecules under realistic astrophysical conditions where chiral species are embedded in an amorphous water-rich ice matrix.Intriguingly, amino acids in highly aqueous-altered meteorites show more than 20% enrichment in L enantiomers, indicating hitherto undiscovered asymmetric amplification mechanisms during secondary alteration processes within parent celestial bodies. While extraerrestrial amino acids have been extensively studied, sugar monomers and aminonitriles are equally important, potentially serving as precursors to amino acids. Neglecting their chiral bias and the prospects of a possible chirality transfer or mutual chiral amplification mechanisms between amino acids and sugars represents a gap in current research. The ICE-EEVOLVE project aims to unravel the journey of amorphous ice and chiral organics from molecular clouds to evolved planetary systems, exploring asymmetric chemical evolution influenced by circularly polarized starlight and alteration processes. This will be achieved through novel laboratory experiments on amorphous interstellar ices processed using synchrotron, laser, and hydrogen lamp sources, combined with enantioselective analyses of pristine extraterrestrial samples. Our research is guided by the idea that the co-evolutionary histo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Two-dimensional colloidal nanostructures - Synthesis and electrical transport' (2007-2013).

assistant: **Innovation**

We propose to develop truly two-dimensional continuous materials and two-dimensional monolayer films composed of individual nanocrystals by the comparatively fast, inexpensive, and scalable colloidal synthesis method. The materials’ properties will be studied in detail, especially regarding their (photo-) electrical transport. This will allow developing new types of device structures, such as Coulomb blockade and field enhancement based transistors.Recently, we demonstrated the possibility to synthesize in a controlled manner truly two-dimensional colloidal nanostructures. We will investigate their formation mechanism, synthesize further materials as “nanosheets”, develop methodologies to tune their geometrical properties, and study their (photo-) electrical properties.Furthermore, we will use the Langmuir-Blodgett method to deposit highly ordered monolayers of monodisperse nanoparticles. Such structures show interesting transport properties governed by Coulomb blockade effects known from individual nanoparticles. This leads to semiconductor-like behavior in metal nanoparticle films. The understanding of the electric transport in such “multi-tunnel devices” is still very limited. Thus, we will investigate this concept in detail and take it to its limits. Beside improvement of quality and exchange of material we will tune the nanoparticles’ size and shape in order to gain a deeper understanding of the electrical properties of supercrystallographic assemblies. Furthermore, we will develop device concepts for diode and transistor structures which take into account the novel properties of the low-dimensional assemblies.Nanosheets and monolayers of nanoparticles truly follow the principle of building devices by the bottom-up approach and allow electric transport measurements
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'The role of memory in perception: neural mechanisms and computations'.

assistant: **Innovation**

Perception and memory are intimately linked, yet they are traditionally studied separately, with knowledge gained in one field not significantly impacting the other. Here, I propose to investigate if and how a canonical memory region, the hippocampus, influences perception. Specifically, I hypothesise that the hippocampus generates predictions based on multisensory associations in our environment (e.g. a barking sound predicts that you will see your dog), and sends these predictions to visual cortex, thereby changing what we see. The proposed research uses the gamut of cognitive neuroscience techniques, from cutting-edge neuroimaging to carefully designed psychophysics and machine learning, to investigate the neural mechanisms and computations whereby the hippocampus and visual cortex interact. I will exploit the anatomical precision afforded by 7 Tesla functional magnetic resonance imaging (fMRI) to pinpoint hippocampal subfield-specific signals and their communication to cortical layers, and the temporal precision of magnetoencephalography (MEG) to investigate how the hippocampus coordinates learning and predicting using oscillations. Additionally, I will use deep neural networks (DNNs) to reveal the contents of hippocampal representations during perception. Together, I expect that this work will lead to a step change in our understanding of the interplay between memory and perception, since the hippocampus is generally considered a ‘pure’ memory region, whereas I propose that it actually changes how we see the world. Resolving this issue will establish the neural mechanisms whereby memory and perception interact, shedding light on how our brains generate our rich subjective experience of the world. Ultimately, this will improve our understanding of disorders where pe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'HEavy precipitation in the Alpine Region'.

assistant: **Concept**

To establish a muti-year systematic collection of heavy precipitation episodes by processing combined data sets from ground based radar, surface and upper air observations. To analyse major precipitation events by applying operational and research-type numerical weather forecast models and to quantify the underlying physical processes. To adapt airborne radar algorithms to measurements over mountainous terrain. To develop and to implement new high-resolution numerical techniques (non-hydrostatic grid nesting).These objectives will substantially contribute towards improving the prediction of precipitation and flooding  events in the Alpine region, and the research will provide valuable observational and numerical data sets suited  for continuing research in this area.  The project structure consists of six work packages:  A1: Systematic monitoring of precipitation systems from recent years A2: Coherent evaluation of operational precipitation forecasts A3: Detailed investigation of major cases  B1: Feasibility of airborne Doppler radar techniques over complex orography  B2: Implementation of advanced modelling techniques  B3: Process studies of the key physical mechanisms.  The work packages A1, A2, A3 place the emphasis on observed cases and the application of established  techniques, while packages B1, B2, B3 concentrate on process studies of key physical mechanisms and advanced  techniques which are under development.  Regarding the applied methods the projects aims at a balanced blend of observations from:  - advanced ground based radars (some Dopplerized/polarimetric) - routine surface networks (partly automatted)  - routine upper air soundings  and simulations from:  - operational weather forecasting models  - research models concentrating on key mechanisms  - tests