RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanisms of protein translocation in ER-associated protein degradation and the related protein import into the apicoplast of Plasmodium falciparum' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The removal of misfolded proteins is an essential process in all cells. Failure to dispose of such proteins often results in disease. A particularly intriguing process serves to discard misfolded proteins from the endoplasmic reticulum (ER). The ER does not itself degrade proteins, so machinery has evolved that moves misfolded proteins into the cytosol where they can be degraded by the proteasome. This retro-translocation process is called ERAD (for ER-associated protein degradation). By comparison with other membrane translocation processes, the mechanism of ERAD is poorly understood. How are misfolded proteins distinguished from folding intermediates? How are proteins moved across the membrane? How is the energy for membrane translocation provided? To answer these fundamental questions I will use a combination of in vitro reconstitution experiments with purified proteins from S. cerevisiae and experiments in intact yeast cells. It appears that some ERAD components have been adapted to function in protein translocation in a very different setting. Many parasites like the malaria causing P. falciparum contain a plastid-like organelle, called the apicoplast. It is the site of several metabolic pathways essential for the parasite’s survival, and thus an important drug target. Like other organelles of endosymbiotic origin, the apicoplast lost most of its genetic information and has to import proteins. This is a particularly challenging endeavour because four membranes surround the apicoplast. It is thought that symbiont specific ERAD-like machinery (SELMA) mediates proteins translocation across the second-outermost membrane. However, not much is known about SELMA. What is its molecular composition? Which aspects of SELMA are conserved in comparison to the classical ERAD ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Institutional Changes and Trajectories of Socio-Economic development Models'.

assistant: **Innovation**

The aim of the project is to analyse, within a comparative institutionalist analytical framework, the trajectories of socio-economic development models. Comparative analyses of forms of capitalism have underlined the diversity in institutional configurations. Within the EU, it is assumed that four types of socio-economic models exist: market-oriented, continental, Nordic, and Southern, with the position of transitional CEEC under discussion. The project will reconstitute the historical trajectories of these socio-economic models, in order to understand how their institutional configuration mediates the synergies and trade-offs between the economic, social and environmental dimensions of development. By focusing on complementarities and conflicts as well as changes in socio-political compromises, by contesting the hypothesis of convergence towards a specific European model and by analysing the impacts of globalisation and structural reforms, the possible future for these models will be discussed. The project will combine three approaches Firstly, a quantitative analysis of the trajectories of socio-economic models. Using long-term data bases for industrialized countries, statistical and econometrical analyses will allow for a quantitative historical analysis of trajectories for the period 1975-2005. The analysis will be completed with analysis of CEEC and emerging countries for the period 1990-2010. Secondly, a comparative analysis of socio-political dynamics and institutional changes. Twelve European and four non-European countries will be examined in order to identify, from an historical perspective, the evolution of socio-political compromises and their influence on the dynamics of institutional changes. Thirdly, sectoral analyses of institutional configurations and i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Modes of Expectation Formation in Macro and Finance' (MODES).

assistant: **Concept**

Expectations are central in macroeconomics and finance. I propose to study modes of expectation formation in macro and finance: the ways in which expectations are constructed. These modes can differ in the inputs used and in how these inputs are processed. For instance, agents could consider relevant macroeconomic state variables and process this information through a developed mental model of the economy. A different approach could be based on spontaneous recall of easily accessible personal experiences and use of a simple heuristic.Empirical studies suggest that different modes are relevant, but we do not understand their relative importance, drivers, decision-relevance, and aggregate consequences. This poses a barrier to a unified understanding of belief formation, preventing the field from moving forward. My objective is to answer these questions for the most central domains in macro and finance. I use a novel portable, survey-based approach building on an AI chat, laying the groundwork for a unified account of macroeconomic expectation formation.In Part 1, I study modes of forming inflation expectations among households, managers and experts. I use experiments to understand how rational inattention and memory shape modes of belief formation. I use a New-Keynesian model to study macro consequences.In Part 2, I study modes of expectation formation about aggregate stock returns using surveys with investors. I use linked administrative bank account data to study the consequences of the mode of belief formation for the pass-through of beliefs to decisions. I explore aggregate implications in an asset pricing model.In Part 3, I study modes of expectation formation about aggregate unemployment. I conduct household surveys linked with administrative register data to unders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Subversion of the host cell by Shigella flexneri: the role of the type III secretion substrates OspB and OspC1'.

assistant: **Innovation**

Many gram-negative bacterial pathogens, including the intracellular human pathogen Shigella flexneri, use a dedicated secretion system, termed type III secretion (TTS) system, to inject bacterial proteins directly from the bacterium, across the host plasma membrane, into the host cell cytosol. The translocated bacterial effectors facilitate infection and virulence by manipulating host signalling pathways, including those regulating apoptosis, cytoskeletal rearrangements and cytokine production. Recently, a n umber of new effectors, named Osps (outer Shigella proteins), including OspB and OspC1, that are secreted by the TTS system of S. flexneri.We hypothesize that OspB and OspC1 are secreted into the invaded host cell to subvert the host cell response to bacterial infection and facilitate the disease process. To test this hypothesis we aim to characterize the function of OspB and OspC1 by:i. analysing the in vitro and in vivo phenotype of OspB and OspC1 deletion mutants,ii. following the fate of OspB and Osp C1 in the host cell, andiii. identifying cellular targets of OspB and OspC1.These experiments will lead to a greater understanding of the subversive mechanisms used by S. flexneri and other gram-negative pathogens to manipulate the host and cause disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ghosts from the past: Consequences of Adolescent Peer Experiences across social contexts and generations' in the context of a Horizon 2020 call.

assistant: **Objectives**

Positive peer experiences are crucial for young people’s health and wellbeing. Accordingly, multiple studies (including my own) have described long-term negative psychological and behavioral consequences when adolescents’ peer relationships are dysfunctional. Paradoxically, knowledge on adult social consequences of adolescent peer experiences –relationships with others a decade later - is much less extensive. Informed by social learning and attachment theory, I tackle this gap and investigate whether and how peer experiences are transmitted to other social contexts, and intergenerationally, i.e., passed on to the next generation. My aim is to shed light on how the “ghosts from peer past” affect young adults’ relationships and their children. To this end, I examine longitudinal links between adolescent peer and young adult close relationships and test whether parents’ peer experiences affect offspring’s peer experiences. Psychological functioning, parenting, temperament, genetic, and epigenetic transmission mechanisms are examined separately and in interplay, which 1) goes far beyond the current state-of-the-art in social development research, and 2) significantly broadens my biosocially oriented work on genetic effects in the peer context. My plans utilize data from the TRAILS (Tracking Adolescents’ Individual Lives’ Survey) cohort that has been followed from age 11 to 26. To study intergenerational transmission, the TRAILS NEXT sample of participants with children is substantially extended. This project uniquely studies adult social consequences of peer experiences and, at the same time, follows children’s first steps into the peer world. The intergenerational approach and provision for environmental, genetic, and epigenetic mediation put this project at the forefront
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Doping Compensation in Thin Silicon Sensors: the pathway to Extreme Radiation Environments' (CompleX).

assistant: **Innovation**

Silicon sensors have been extensively exploited in high-energy physics experiments in the past 40 years, from their first use in NA11 at the SPS (CERN) to their application in the present-day design of very large particle trackers. The capability of silicon sensors to work in environments with high radiation levels has been of utmost importance for experiments at accelerating machines with very energetic and intense particle beams. Presently available silicon sensors can operate efficiently up to particle fluences of 2E16/cm2, while future frontier accelerators envisage the use of silicon sensors in environments with fluences exceeding 5E17/cm2. If not overcome, this gap will prevent the use of silicon sensors in future hadron-collider experiments.CompleX aims at extending the range of operation of silicon detectors by more than one order of magnitude, up to a fluence of 5E17/cm2. The idea behind this unprecedented target in radiation tolerance relies on a novel understanding of the saturation of the radiation damage and on the advantages that compensated implants bring to radiation hardness. The application of these two breakthroughs to thin silicon sensors (20–40 microns) with an internal gain of 10–20 will allow the design of sensors able to operate up to the target fluence.I am the PI of three projects to develop silicon sensors for extreme fluences (eXFlu – INFN, eXFlu-innova – AIDAinnova, FLEX – UNITO), which represent preparatory developments for the CompleX proposal. In this context, I introduced the principle of doping compensation in silicon sensors to the detector community. My expertise in the design and testing of silicon sensors, my involvement in radiation hardness studies, and my experience in project coordination qualify me as a recognised expert in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Anti-Biopharmaceutical Immunization:Prediction and analysis of clinical relevance to minimize the risk' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines. ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recruited per year. This should lead to the constitution of the largest possible cohort in Europe for the study of immunogenicity, a condition critical for the success of the program. ABIRISK will also benefit from the unique expertise of immunologist partners in the development of innovative strategies for predicting the immunogenicity of biopharmaceuticals and for defining its mechanisms. The large number of patients enrolled in the ABIRISK cohorts should make it possible to study the genetic basis of immunogenicity in a new way. We will standardize all clinical and biological information before its integration into a large database for evaluation of the clinical relevance of immunization against biopharmaceuticals and stratification of the risk to patients as a function of factors linked to treatment or to the individual. Computational biology and biostatistical modeling will be used to develop models for predicting immunogenicity that will be validated with the ABIRISK database.The complementarity between the clinical partners from different disciplines, immunologists, methodologists and biostatisticians will create a unique task force for studies of biopharmaceutical immunogenicity. The direct outcomes of the proposed work will be greater understanding of the mechanisms involved in the emergence of anti-drug antibodies, the development of new methods for predicting immunogenici
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Unraveling Bilobalide Biosynthesis for Sustainable and Scalable Production in Yeast' (2021-2027) under Horizon Europe.

assistant: **Objectives**

Ginkgo biloba extracts are among the most widely used plant-based health supplements in the United States and Europe. However, increasing demand has led to unsustainable overharvesting, resulting in Ginkgo biloba being classified as an endangered species. These extracts contain bioactive compounds, such as ginkgolides and bilobalide. Bilobalide, in particular, is valued for its neuroprotective, anti-ischemic, and insect-repellent properties, with potential applications in treating Alzheimer’s disease, dementia, sclerosis, and as a biopesticide.To address these societal and environmental challenges, this project aims to develop a scalable, sustainable production platform for bilobalide using synthetic biology in baker’s yeast. This approach will reduce pressure on G. biloba populations, contributing to biodiversity preservation while promoting innovative biotechnological solutions to meet the demand for natural products. A central focus of this research is to elucidate the biosynthetic pathway of bilobalide, which remains poorly understood.It is hypothesized that bilobalide is synthesized either via sesquiterpenoid pathways or through the degradation of ginkgolides. Using complementary experimental systems in yeast and tobacco, I will systematically test both hypotheses to uncover the key biosynthetic steps. Once the bilobalide biosynthesis pathway is elucidated, I will engineer it in baker’s yeast to create a cost-effective, scalable, and sustainable production system.This project will leverage the tools and datasets available in the host lab, along with my expertise in plant secondary metabolism and pathway gene characterization, to achieve its goals. It aligns with the European Union’s priorities of fostering innovation, sustainability, and natural resource conservati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The role of abc-transporters in pathogenicity and sexual reproduction of mycosphaerella graminicola, the causal agent of septoria leaf-blotch of wheat.' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content heterogeneous group of peripheral neuropathies with an overall prevalence of 1 in 10.000. Charcot-Marie-Tooth disease (CMT) is the most common form of HMSN and has a frequency of 1 in 2500 in Europe. CMT is a heterogeneous disease studied extensively in different research areas such as neurology, neuro- pathology, neurobiology and genetics. Other forms of HMSN and related disorders, such as the hereditary neuropathy with liability to pressure palsies (HNPP) and distal hereditary motor neuropathy (distal HMN) or spinal CMT are being studied. The objective of this BIOMED2 reinforced concerted action application is to encourage collaboration between 46 European laboratories working in the field of CMT and related peripheral neuro- pathies, bringing together their expertise to find solutions to the different research areas. The reinforced concerted action will be coordinated by the project leader in conjunction with the steering group. The various activities will be carried out by the European research teams in order to achieve the defined objectives and targets. The leader will centralize the data obtained in the research field anddisseminate the informations and results. The aims of the European HMSN consortium group can be summarized as: transfer of researc and diagnostic information between the members of the consortium, efficient distribution of genetic material, introduction of new methods for research and diagnostic purposes, solving problems and discussing results during annual meetings of the consortium group via oral presentations and/or poster sessions at the site of the European Society of Human Genetics, organisation of topic specific workshops by sub-committees, mobility and training of young researchers, clinicians and technica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for '18th meeting of the european society of animal cell technology. granada, may 2003' to be submitted under Fifth Framework.

assistant: **Abstract**

The proposal presented pursues to stimulate the participation of young European researchers and scientists from the Associated States to the 18th Meeting of the European Society of Animal Cell Technology, to be celebrated in Granada, Spain, in May 2003. This meeting is at the present one of the most important meetings on this technology, receives about 700 delegates, with about 500 Europeans. The main companies and scientist in the field are well represented. In addition of up-date lectures on Animal cell technology and its applications to the production of biopharmaceutical products, drug discovery programmes, cell and gene therapies, the meeting will offer an intensification on the impact of geophysics in this area including a crush course on these techniques, especially dedicated to the young researchers attending the meeting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of new methods for the solid phase synthesis of benzoannelated nitrogen heterocycles' (1998-2002).

assistant: **Innovation**

Development of new methods in the solid phase synthesis of biological-active compounds in the context of combinatorial chemistry. One of the main objectives of organic and medicinal chemistry is the design, synthesis, and production of molecules having value as human therapeutic agents. In recent years, the synthesis of combinatorial libraries has emerged as a valuable tool in the search for novel lead structures. The generation of molecular diversity to create libraries for drug discovery is an important objective for the applicant; due to her interest in medicinal chemistry, and for the host due to his interest in develop new methods solid phase chemistry.