RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'PREventive Care Infrastructure based On Ubiquitous Sensing'.

assistant: **Objectives**

PRECIOUS: PREventive Care Infrastructure based On Ubiquitous Sensing will provide a preventive care system to promote healthy lifestyles, which is comprised of three components: (1) transparent sensors for monitoring user context and health indicators (food intake, sleep and activity) deliver ambient data about current user behavior; (2) users are represented by individual virtual models which allow inferring health risks and desired behavioral changes; (3) state-of-the-art motivational techniques originating especially from gamification and motivational interview trigger a set of feedback tools to change the user habits toward more healthy conduct.<br/>While related projects usually focus on developing specific sensors, middleware solutions, health monitoring systems, eHealth services, etc., both the individual virtual model and the associated motivational tools will now provide key innovation steps towards a preventive care system with measurable impact on user behavior and thus a clear potential for large scale commercialization and sustainable societal footprint (e.g. with respect to cost saving in the public health sector as well as life quality improvements).<br/>To reach these goals, PRECIOUS consortium gathers partners from academia, SMEs and hospitals with comprehensive expertise in networking, pervasive sensing, cognitive analysis, nutrition research, semantic technologies and motivational techniques. We have chosen to focus on type II diabetes as a central use case, while our prototype will be easily adaptable also to other lifestyle induced diseases. The system will not only detect and communicate detailed early warning signs, but also provide forecasts of future developments and associated problems (if change recommendations are not followed). Extensive lab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Conductive characteristics and mass fabrication of nanoscale integrated circuit nanowires' (NANOWIRES).

assistant: **Concept**

Objectives of the project are: Quantifying the limits and stability of electron conduction in short and long Nanowires, determining the low-temperature properties and the effects of space and charge quantisation on transport through Nanowires, quantifying, optimising and modelling transport properties of a molecular-metal junction and realising methods for parallel fabrication of Nanowires by elastomeric stamping.This variety of phenomena and possibilities will be explored in wires ranging from 0.1µm to atomic dimensions and with length scales from 0.1µm to a few nanometres. Fabrication and characterisation using both high-resolution electron beam lithography and scanning probe techniques (STM, AFM, SNOM, SSFM, MFM, conducting AFM) will be used. Additionally first principle calculations and transport theory for the metallic and molecular nanowires will be performed so as to augment the experimental work. The members of the consortium have been chosen by their abilities and proven specialities to realise the points above.Exploitation of the results of the project will open new perspectives in the coming era of nanoscale circuit integration. Terabytes of information storage will be possible where single molecules and the current flowing through them will be able to switch a specific unit in the circuit. However, even if the writing technique might be able to achieve a circuit interpretation, there is no way that this interpretation can take place and be functional if the conduction and the I-V characteristic of the interconnecting nanowires are not understood. The technological implications of these studies are the basis for the future integrated nanoscale device.In the future development of nanoscale integrated circuits and devices a crucial element is the role of the in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SUstainable and PERsuasive Human Users moBility in future cities' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The SUPERHUB project aims at realizing a new services mobility framework supporting an integrated and eco-efficient use of multi-modal mobility systems in an urban setting.SUPERHUB provides a user-centric, integrated approach to multi-modal smart urban mobility systems, through an open platform able to consider in real time various mobility offers and provide a set of mobility services able to address user needs, promote user participation and to foster environmental friendly and energy–efficient behavioural changes. Moreover, the take-up of virtuous behaviours, characterized by a reduced environmental footprint, is also facilitated by the SUPERHUB open platform matchmaking and negotiation capabilities between (public-private) providers and consumers of mobility offers and by the use of persuasive technologies to achieve wide adoption of results.To achieve these objectives SUPERHUB will develop a persuasive engine based on captology principles to facilitate the voluntary adoption of environmentally-friendly multi-mobility habits, novel methods and tools for real-time reasoning on large data streams coming from heterogeneous sources, new algorithms and protocols for inferring traffic conditions from mobile users by coupling data from mobile operator networks with information coming from GPS based mobile phones and for dynamic matchmaking or resources that will generate journey plans best fulfilling user mobility needs and preferences while minimizing negative environmental impact.Specific services and user studies will be realized to demonstrate the SUPERHUB concepts and technologies through field trials in Barcelona, Helsinki and Milan, involving large end-users communities. Results of SUPERHUB field trials shall influence local policy makers and municipalities in the d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'CHD1 Deletion: Implications to Outcome and Treatment in Prostate Cancer' (CDELP) under Seventh Framework.

assistant: **Objectives**

Prostate cancer can be stratified as ETS gene rearranged (ETSR) andnon-rearranged (ETSNR), with the latter comprising a heterogeneousgroup of 50-60% of all cancers. This project will characterize a subgroupof ETSNR cancers that have a CHD1 deletion (CHD1del). Recentsequencing studies have elucidated CHD1- cancers as ETSNR, andcommonly PTEN and p53 wildtype and SPOP mutated, comprising up to26% of all prostate cancers (1). ETSR cancers largely have hormonedriven oncogenes that may have prognostic and predictive utility (2, 3).Less is known about ETSNRCHD1del cancers. Their lack of ETS fusionsraises concern that these may not be generated through androgenreceptor (AR) transcription and are not AR driven. ETSNRCHD1del cancershave a huge excess of somatic intrachromosomal rearrangements (up to800) compared to ETSR cancers presumably due to a DNA repair defect(1). This is supported by CHD1’s association with the SSRP1, part of theFACT complex, that is implicated in transcriptional regulation and DNArepair (4-9). We hypothesize that CHD1 deleted tumors are lesssensitive to endocrine and taxane therapy, have a worse prognosisand need alternative treatment strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Retinal Imaging prevention and early detection of chronic diseases' (RETINAL) targeting Horizon 2020.

assistant: **Abstract**

"The World Health Organization (WHO) in its “Global status report on noncommunicable diseases 2014” shows that the impact of noncommunicable diseases (NCDs), also known as chronic diseases, is steadily growing. NCDs are the leading cause of death globally (68% of all deaths in 2012). The 4 main types of NCDs are cardiovascular (CVD) diseases (like cerebrovascular accidents or strokes and heart attacks), cancers, chronic respiratory diseases and diabetes. Cardiovascular diseases account for most NCD deaths (17.5 million people annually), followed by cancers (8.2 million), respiratory diseases (4 million), and diabetes (1.5 million).This proposal addresses the prevention and early diagnosis of 2 types of NCDs, Cardiovascular (CVD) diseases and diabetes, by providing health professionals a tool for automatic quantification of parameters of the retina and automatic detection of lesions of the retina, with capacity for prevention and/or early detection of various diseases.ULMA Embedded Solutions (UES) has developed a non-invasive and cost-effective tool for Automatic evaluation of Retinal Imaging Biomarkers (ARIB), which can be used in public health interventions delivered through a primary health-care approach to strengthen early detection and timely treatment of various diseases. Evidence shows that such interventions are excellent economic investments because, if applied to patients early, can reduce the need for more expensive treatment. """"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Acetogenic bacteria: from basic physiology via gene regulation to application in industrial biotechnology' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Demand for biofuels and other biologically derived commodities is growing worldwide as efforts increase to reduce reliance on fossil fuels and to limit climate change. Most commercial approaches rely on fermentations of organic matter with its inherent problems in producing CO2 and being in conflict with the food supply of humans. These problems are avoided if CO2 can be used as feedstock. Autotrophic organisms can fix CO2 by producing chemicals that are used as building blocks for the synthesis of cellular components (Biomass). Acetate-forming bacteria (acetogens) do neither require light nor oxygen for this and they can be used in bioreactors to reduce CO2 with hydrogen gas, carbon monoxide or an organic substrate. Gas fermentation using these bacteria has already been realized on an industrial level in two pre-commercial 100,000 gal/yr demonstration facilities to produce fuel ethanol from abundant waste gas resources (by LanzaTech). Acetogens can metabolise a wide variety of substrates that could be used for the production of biocommodities. However, their broad use to produce biofuels and platform chemicals from substrates other than gases or together with gases is hampered by our very limited knowledge about their metabolism and ability to use different substrates simultaneously. Nearly nothing is known about regulatory processes involved in substrate utilization or product formation but this is an absolute requirement for metabolic engineering approaches. The aim of this project is to provide this basic knowledge about metabolic routes in the acetogenic model strain Acetobacterium woodii and their regulation. We will unravel the function of “organelles” found in this bacterium and explore their potential as bio-nanoreactors for the production of biocommodities and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Fast & automated droplet tracking tool for microfluidics' (DROPTRACK).

assistant: **Concept**

Microfluidics technology targets droplet manipulation by confining fluids to manufacture materials for many industrial applications and life sciences. Data analysis obtained by microfluidic experiments remains a bottleneck to this day due to the lack of a reliable interface converting raw observations to informative data fast enough and at low operating costs. Many computer vision tools exist, which permit to infer useful physical information from video data but they typically target specific physical systems and lack broad applicability. Moreover, the existing tools need intensive development and fine-tuning before they can be useful in a specific scenario. Thus, such a lack of computer vision tools with broad applicability hinders the penetration of this technology for extensive microfluidics applications.This PoC aims to develop a stand-alone, easy-to-use software (DropTrack) that can detect and track individual droplets from experimental videos. Two cutting-edge deep-learning algorithms, YOLO for droplet detection and DeepSORT for droplet tracking, will be at the software's core. DropTrack will provide trajectories of the individual droplets and measure physical quantities of interest, such as the droplet numbers, flow rates, packing fraction, etc., by analyzing videos from experiments. Our preliminary work indicates that DropTrack is capable of analyzing images much faster than the image capture rate of a typical digital camera, thereby opening entirely new prospects for real-time feedback control in experiments. The realization of DropTrack will lead to dramatic time and resources savings in video data analysis of deformable moving objects in microfluidics. Beyond this PoC, the successful demonstration of this technology in microfluidics is expected to attract sig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Mesoscopic THz impedance microscopy for quantum materials'.

assistant: **Objectives**

An important frontier in condensed matter physics is the understanding of quantum materials in which different ground states compete, leading to electronic inhomogeneity and the concept of ‘quantum electronic liquid crystals’. The challenge for experiments is to measure the local electrodynamic properties in materials, which are electronically inhomogeneous, but atomically homogeneous.I propose a new technique to determine these local variations of the electronic properties. The central objective is to measure with nanometer-scale spatial resolution the frequency-dependent electrodynamic properties, such as complex dielectric constant and complex conductivity of quantum materials at frequencies in the several hundreds of GHz range. The method is derived from the recent progress in astronomical instruments for the submillimeter (hundreds of GHz to THz) frequency band. This progress, to which I contributed extensively, is driven by the desire to study the universe. Now, with this technology and expertise in hand, the disciplinary boundaries can be crossed once more and directed to the other challenging frontier of quantum materials. With this instrument it will become possible to determine the local (and possibly frequency-dependent) electromagnetic properties, such as the dielectric constant and conductivity, for a range of materials.Through this technique, I will make it possible to study the local properties of new materials and even to get access to the local energy-scales of their excitations. It is clear that the program is ambitious and risky, but if successful it provides a major step forward in experiments to reveal the various electronic states of quantum materials and a new scanning-probe technique operating in a new frequency range.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'NR4A2 target genes important in Parkinson's Disease' in the context of a Sixth Framework call.

assistant: **Objectives**

The major motor disabilities of Parkinson's disease (PD) are associated with the progressive loss of dopaminergic neurons in the substantia nigra. The physiological changes and biochemical pathways involved in the selective demise of these neuronsare unclear. Survival of the dopaminergic precursor neurons during differentiation requires the function of NR4A2, a ligand independent nuclear receptor. Mutations in NR4A2 have been discovered in patients with familial PD. The mutations resulted in a marked decrease in NR4A2 mRNA levels in transfected cell lines and in lymphocytes of affected individuals.Additionally, the mutations in NR4A2 affected the transcription of the gene encoding Tyrosine Hydroxylase (TH), an enzyme required for dopamine biosynthesis. Endogenous ligands that regulate RXR function as well as synthetic H gands that activate NR4A2-RXR heterodimers have been shown to mediate RXR ligand-induced signalling in neuronal cells. TheseRXR ligands require the presence of NR4A2 and increase the number of surviving dopaminergic cells and other neurons.It is speculated that NR4A2, as a transcription factor, controls the expression of neuroprotective factors possibly by associating with RXR. In this proposal we aim to identify such factors. Since the number and the identity of the genes whose expression is controlled by NR4A2 and/or NR4A2/RXR heterodimers are unknown we propose to identify these genes and determine the function of the ones that mediate neuroprotective effects. In addition, we propose to clarify the transcriptional relationship of NR4A2 to the other genes that have been linked to familial PD including alpha-synuclein, parkin, DJ1, UCHL1 and PINK. The results of our experiments may reveal the factors that lead to the prevention or perhaps reversal of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Novel active nanophotonic devices in rare-earth doped double tungstates' under Seventh Framework.

assistant: **Concept**

The objectve of Re-ACT is to establish the foundations for a long-term research effort in integrated active nanophotonic devices based on the use of rare-earth doped double tungstate crystalline materials. Re-ACT puts together several disruptive leading edge technologies in an innovative manner to solve several important problems that are hindering the complete integration of nanophotonic circuits. Research areas that will be investigated include plasmonic propagation with gain, gain assisted all-optical processing, integrated optical isolators and the use of plasmonic resonant effects for novel on-chip sensing devices and nanolasers.It is expected that the results obtained in Re-ACT will lead to several breakthroughs that will enable the realization of long searched fully integrated active nanophotonic devices. The possibility to integrate as much functionality on the chip as desired, with almost unlimited bandwidth and with very low power consumption will open the door to new concepts in telecommunications, computing and personal entertainment that will revolutionize the way human communications will take place. Several breakthroughs in diagnostics, medical imaging and environmental monitoring are also expected.  In our ageing society, there is an increasing need for technologies enabling non-invasive medical diagnostics and preventive medicine. Environmental care will benefit from the deployment of distributed networks of very small and sensitive sensors that will help monitoring our fragile resources. Water could become a scarce resource in the future and the importance of having safe water is increasingly becoming a priority. These realizations will be enabled thanks to the development of novel miniaturized microspectrometers and networks of biosensors coupled with