RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Systems Chemistry: Steps Towards De-Novo Life' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Can we synthesise life de-novo in the lab? This is one of the Grand Challenges of contemporary Science. Overall objective of this project is to set important steps in turning chemistry into biology by building fully synthetic chemical systems that contain and integrate some of the essential elements of life: replication, metabolism and compartmentalisation. Functional coupling of any of life’s essential elements has not been achieved, at least not without making use of biomolecules. We now aim to achieve such coupling and develop fully chemical systems to become increasingly life-like. Specific aims are:1. Achieve and explore Darwinian evolution of a fully synthetic system of peptide-based self-replicating molecules.2. Develop self-replicating molecules that are capable of catalysing not only their own formation, but also other chemical reactions. We will specifically target chemical reactions that result in the production of building blocks which the replicators can utilize to replicate, thereby integrating replication with a rudimentary form of metabolism.3. Achieve self-reproducing compartments and develop ways to couple replication inside compartments with compartment division. Three parallel approaches will be explored, based on (i) vesicle-type compartments made from self-replicating molecules; (ii) coascervates and (iii) compartments made by surfactants that are produced by catalytically active self-replicators.4. Extend replication from peptide-based building blocks to ones containing nucleobases. We also plan to investigate reaction networks made from mixtures of peptide- and nucleobase-containing building blocks).5. Develop kinetic modelling tools that allow an efficient exploration of multi-parameter space of the reaction networks developed in 1-4. Through st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'miR-182 as new Therapeutical Target in Renal Transplantation' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Delayed graft function (DGF) after kidney transplantation represents the main risk factor for allograft loss. While DGF occurs rarely after living donor transplantation, about 25% of deceased donor kidney recipients develop DGF and require dialysis within the first week after transplantation. Various molecular mechanisms have been elucidated. Pro-inflammatory response after brain death and ischemic reperfusion injury are significant factors contributing to development of DGF. Nevertheless, prevention of DGF after transplantation is desirable but still not feasible.MicroRNAs (miRNAs) are a class of small non-coding 18 to 24 nucleotide-long RNAs involved in the regulation of diverse cellular functions and in the pathogenesis of DGF. One of the most appealing properties of miRNAs as therapeutic agents is their ability to target multiple molecules, making them extremely efficient in regulating distinct biological cell processes relevant in specific diseases. One of their members, miR-182 is strongest increased during acute renal transplant failure. miR-182 regulates approx. 50% of significantly deregulated genes in renal allograft biopsies developing DGF within the first week after transplantation. Furthermore the inhibition of miR-182 showed anti-inflammatory properties over the target gene FOXO1.Aims:1. We will investigate whether the inhibition of miR-182 will revert transcriptional activation of genes involved in DGF in the rat donor kidney2. To elucidate the efficacy of miR-182 antisense in preventing the incidence and duration of postischemic DGF in a rat model.3. The third aim is to test the proposed treatment in human deceased donor kidneys, which are declined for transplantation. Machine perfusion technique (lifeport®) will be used to apply the drug into the donor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Femtosecond comb optical parametric oscillators for high-resolution spectroscopy in the mid-infrared' in the context of a Seventh Framework call.

assistant: **Objectives**

The research necessary to extend the application areas of femtosecond frequency combs through the development of compact, robust, low-cost, commercially-exploitable sources is now possible; taking advantage of the fact that ultrafast laser pulses of femtosecond widths, separated by nanoseconds, manifest themselves as a phase-coherent comb of frequencies spread over a wide spectral band. Furthermore, the development of femtosecond frequency combs in the infrared region of the electromagnetic spectrum and beyond offers enormous opportunities for exploitation in broad spectrum detection and metrology.  Robust industrial laser sources such as those produced by the SME supply chain grouping brought together in this proposal can be used by the leading research groups in this consortium to develop frequency comb based spectroscopy systems offering unprecedented detection sensitivity and measurement accuracy.  Moreover, if the wavelength range of the comb sources can be extended to cover the mid-IR region then such a source would be ideal for coherent Fourier-transform spectroscopy in the absorption-rich mid-IR 'molecular fingerprint' region delivering real-time acquisition of molecular spectra and real-time imaging with chemical identification for applications in large fast-growing global markets including environmental monitoring, real-time analysis of chemical /bio threats and explosives, trace molecular detection, and medical breath analysis. The project will be led by the SME group coordinated by M-Squared Lasers and produce IP which can be exploited across the supply chain covering optics, crystals, lasers and OPOs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'AB Initio Simulations for Super-Earths', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Since the discovery of the first exoplanet, a gaseous giant planet, two decades of an extensive planet hunt led to an amazing inventory of close-by planet systems. Among these planets a substantial number are slightly larger than Earth but are still expected to be rocky. No similar object exists in the solar system and little is known about them. One interesting aspect is to determine the habitability of these exotic planets and if life could develop there. It is therefore important to determine what is the structure of the deep interior of these planets and if it can generate a protecting magnetic field.In the proposed project, the fellow plans to develop a set of state-of-the-art ab initio simulations of iron-nickel mixtures to study the properties of these materials at high pressure. These materials are likely to be dominant in the core of Super-Earth but it is unclear if the pressure-temperature conditions are compatible with a solid core surrounded by a liquid and conducting phase as expected to be favorable for magnetic field generation. The fellow will focus on the phase diagram of these mixtures up to 1 TPa. He will also explore the transport properties in order to better constrain the possible scenarios of convection and magnetic field generation. Based on these results, the fellow will build evolution models of Super-Earths to be compared to the discovered exoplanets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'AlgaHealth: novel cultivation technologies of unique microalgae strains for high quality of fucoxanthin-based products.' (AlgaHealth), addressing dissemination and exploitation.

assistant: **Impact**

Obesity, diabetes and other metabolic syndromes affect an increasing proportion of the population and pose significant economic burden to healthcare systems. To prevent and treat lifestyle-related diseases, it is not sufficient to use an exclusively pharmacological treatment. Nutrition also plays a critical role. Therefore, researchers began to find safe and effective functional ingredients in food to prevent and treat such diseases. One of these functional ingredients is fucoxanthin - a golden-brown carotenoid found in macro and microalgae.The common method to harvest fucoxanthin is from macroalgae (brown seaweeds), but it is not an acceptable alternative because it is seasonal, not sustainable and allows to the extraction of very low quantities of fucoxanthin. The only alternative for a more efficient and sustainable production of fucoxanthin are microalgae. However, existing production techniques of microalgae require high investment and large energy input, preventing large scale and sustainable production. At AlgaHealth we isolated, developed and cultivated new and proprietary microalgae strains of Isochrysis species and novel agro-physiological manipulations to make them grow faster and produce more fucoxanthin. These novel technologies constitute a proven and efficient platform for industrial scale production of high quality fucoxanthin-based oleoresin, at lower energy and environmental-friendly production costs.AlgaHealth is an Israeli biotech company founded in 2017 and stemming from its co-founders’ 20-year experience in microalgae and carotenoids industries. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of AlgaHealth products
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Stone conservation for the refurbishment of buildings' (STONECORE) targeting Seventh Framework.

assistant: **Abstract**

STONECORE is a project dealing with the development and application of nano materials for consolidation and conservation of natural and artificial stone. Six SMEs, four universities, one public research organisation and one public body from seven countries have jointed together in order to find a new approach for refurbishment. The idea is to develop and test nano materials compatible to the components originally used during construction together with non destructive stone assessment methods. Colloidal sols of calcium hydroxide, calcium / barium carbonate, calcium sulphate or related compounds will be in the centre of interest. These materials will be used also as new, biozide free agents for mildew removal. The project will lead from laboratory investigations and small scale applications on trial areas to the use of the developed materials on selected real objects. It is a project that aims on knowledge based refurbishment of buildings as well as monuments of cultural heritage and that combines natural sciences and the art of conservation. Thus, main subjects of STONECORE are:    • The development of nano materials compatible to natural and artificial stone for refurbishment of buildings, monuments, fresco, plaster and mortar, • The development and test of suitable technologies for their application and  • The development and test of non destructive assessment methods (such as georadar) in combination with traditional assessment methods (SEM, XRD, drilling resistance and other). The project will have duration of three years. The results will be presented to the public and interested companies in three workshops, in which interested parties are invited to test the developed materials and techniques on own objects. The project contributes to the EC objectives by the deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Centre for energy efficient technologies and systems in indoor environment engineering' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The goal of the Centre is raising the level of scientific skills and engineering abilities of Polish professionals in shaping indoor environment in buildings. The Centre will offer opportunities for Polish specialists to adapt to up-to-date European standards and take advantage of the experience in creating energy effective HVAC systems.In result it will be possible to introduce new, energy efficient devices and systems using RES, apply new methods of assessment and reduction of environment related heal th risks and influence establishing technical and legal regulations concerning the installations in question, patterned on EU acts. The Centre will consolidate links with other similar centres and networks in EU and NAS, preparing the ground for easier and enhanced participation of Polish research centres in 5/6 Framework Programme (Key Act.4&6).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'REAL-time monitoring and mitigation of nonlinear effects in optical NETworks' to be submitted under Horizon 2020.

assistant: **Abstract**

The exponential surge in the global data traffic driven by the skyrocketing proliferation of different bandwidth-hungry on-line services, such as: cloud computing, on-demand HD video streams, on-line business analytics and content sharing, sensor networks, machine-to-machine traffic arising from data-centre applications, the Internet of Things, and various other broadband services, brings about the escalating pressure on the speed (capacity) and quality (bit error rate) characteristics of information systems. It is well recognized nowadays that rapidly increasing data rates in the core fibre communication systems are quickly approaching the limits of current transmission technologies, many of which were originally developed for communication over linear (e.g. radio) channels. It is widely accepted that the nonlinear transmission effects in optical fibre represent now a major limiting factor in modern fibre-optic communication systems. Nonlinear properties make optical fibre channels considerably different from wireless and other traditional linear communications channels. There is a clear need for development of radically different methods for coding, transmission, and (pre & post) processing of information that take the nonlinear properties of the optical fibre into account and for training of a new generation of engineers with expertise in: optical communications, nonlinear science methods, digital signal processing (DSP), design of implementable algorithms. From the industry perspectives, design of practical and implementable processing algorithms requires knowledge of ASICs and real world conditions and restrictions. The mutli-national & multi-interdisciplinary REAL-NET project will provide timely doctoral training for 6 PhD students through industry relevant resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Twinning Innovation Hub for Microbial Platforms in Plastic Upcycling' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Plastics have become indispensable in various industries today, but their widespread use has resulted in a severe environmental crisis—plastic waste accumulation. Traditional methods of plastic waste management are insufficient and recycling faces quality and degradation challenges. Enter upcycling, a process gaining prominence in converting plastic waste into valuable chemicals and materials in an eco-friendly manner.TwInn4MicroUp presents an innovative approach to plastic waste upcycling, employing green bio/mechano/chemical technologies to recover plastic monomers. Modern molecular techniques will be utilized to create microbial cell factories capable of producing bioactive compounds from these plastic-derived feedstocks, revolutionizing industries related to bio-colorants, biotherapeutics, bio-nutraceuticals, biosurfactants, and biomaterials.TwInn4MicroUp is on a visionary mission to create the MicroUp HUB, an advanced Research and Innovation Hub in Synthetic Microbial Biotechnology. In our pursuit of maximal impact, we aim to establish strategic partnerships, strengthen NTUA's capabilities, enhance scientific excellence, and promote entrepreneurship and innovation. Our overarching goal is to establish NTUA at the core of the MicroUp HUB, leaving a lasting legacy by advancing scientific knowledge, environmental protection, public awareness, economic development, and global collaboration. Together, we are steering toward a sustainable and responsible future.


**Keywords:** Mechano-Enzymatic plastic degradation, Upcycling, Synthetic Microbial Biotechnology, Research Innovation Hub, Capacity building, Biopigments, Polyhydroxyalkanoates, Bio-oil, Bio-surfactants
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Compensatory strategies across languages during reading acquisition'.

assistant: **Innovation**

Reading acquisition primarily relies on acquiring novel orthographic forms. In this process, efficient decoding of orthographically novel words can be difficult due to the unpredictability of the written-spoken language relationship. Thus, children are forced to develop strategies for effectively acquiring novel words. The main goal of my project is to investigate the compensatory strategies employed by novice readers. I will study two compensatory strategies: one suggests employing a larger processing grain during decoding for better accuracy, based on the Grain Size Theory, while the other recommends using contextual cues to learn despite decoding inaccuracies.Given the predominant focus on English monolinguals in behavioral and computational studies and the central role of language opacity in reading, I will focus on languages with varying degrees of opacity. Additionally, I will also study reading acquisition among bilingual individuals, considering the widespread prevalence of bilingualism in Europe, an area that has been relatively under-explored.In the study of compensation strategies, I identified both computational and behavioral research needs in the literature. Therefore, in this project, I propose a computational study to define a reliable opacity measure. Building on the computational model of reading acquisition I developed during my PhD, I also aim to simulate the Grain Size Theory, and implement a bilingual reading acquisition model to simulate relevant behavioral data. Additionally, I will conduct cross-linguistic behavioral studies on context effects, including both monolingual and bilingual individuals.Cross-linguistic comparisons will help improve the generalizability of findings, addressing an urgent need in the literature. This multidisciplinary ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Tha novo catalytic synthesis of β-aminoacids from CO2' (NOVOCAT) under Horizon 2020.

assistant: **Objectives**

This proposal deals with the development of an innovative and unconventional catalytic de novo approach to β-amino acids, compounds of remarkable biological significance, using simple, available and abundant carbon dioxide (CO2) as C1 synthon. Specifically, NOVOCAT will promote a synergistic catalytic C-N bond-cleavage/CO2 insertion event of readily available aziridines from a synergistic and rather challenging C-N cleavage/CO2 insertion event. The project will offer all the necessary understanding behind the factors influencing both C-N bond-cleavage and the subsequent CO2 insertion event, thus opening up new horizons in preparative organic chemistry as well as offering solutions to a social, industrial and academic problem such as the use of CO2 as chemical feedstock. NOVOCAT´s design will allow for promoting a counterintuitive catalytic desymmetrization or dynamic kinetic resolution events of aziridines with CO2 en route to β-amino acids. This proposal will lead to new knowledge in synthetic design, thus providing new logics in retrosynthetic analysis that will likely attract the interest of both pharmaceutical and industrial laboratories.