RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unraveling the impact of polyfluoroalkyl substances on aquatic microbial communities to create biodegrading microbial consortia between mixotrophs and fungi' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Polyfluoroalkyl substances (PFAS) are compounds widely used in commercial and industrial applications. Due to their presence in many household products, they are often found in wastewater effluent and urban runoff, from where they reach other aquatic ecosystems. PFAS present several significant issues associated to their persistence, transport (they have been detected in more than 90% of European rivers); and health effects as endocrine disruptors. The main objective of the MIXFUN project is to understand how PFAS may impact the structure of aquatic microbial communities by favoring organisms capable of degrading them, and to use this information to develop biological systems (microbial consortia) based on organisms with high biodegradation potential in combination with physical conditions (ultraviolet radiation-UVR and temperature) that enhance their capacity. We know that the presence of organic carbon in PFAS molecules could be their Achilles' heel, and that those microbial organisms capable of using this carbon could biodegrade the compounds in a cheaper and more sustainable manner than physico-chemical treatments. Additionally, temperature can influence biodegradation metabolism, while UVR has shown a photodegradative effect on PFAS. Since microorganisms coexist in their natural environment with fluctuations in UVR and temperature, our proposal to create a hybrid system of microbial consortia under various UVR and temperature conditions could yield satisfactory results. To achieve this, we plan to identify mixotrophs and fungi that are favored through a gradient of PFAS-contaminated lakes and subsequently develop mixotroph-fungi consortia. By combining empirical data and predictive models, we will be able to determine the optimal growth and biodegradation condition
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'De nova of transcription regulators from taxol®-producing endophytic fungi' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

SummaryWe propose to biosynthesis de novo of fungal taxol® production by the regulation of transcription factors (TFs). However, such a scenario is not yet to be investigated in case of taxol-producing endophytic fungi. The principle aim of this project is to isolate TFs genes WRKY, AP2, MYP etc. that specifically regulate the expression of taxol biosynthetic rate limiting gene promoters using transient RNAi. The attractive features of this study, examining the elicitor-induced regulator of selected TFs genes to see whether their mRNA levels correlate with fungal taxol biosynthesis. In order to identify key regulators of taxol pathway, cDNAs will be explore to obtain the recombinant TF protein. This project offer de nova interactions between the TFs and the TB gene promoters, which results of DNA binding cis-elements. It can be exploited to produce superior increased taxol yields from wild or transgenic fungi. This programme of work will provide a new strategy for unlocking the full potential of fungal biotechnology at the interface with metabolic engineering and rDNA technology to establish of fungal fermentation through genetic engineering approaches. The complementary expertise of Dr Kamal (Fungal biotechnology) and the supervisor Prof. Dr. Frank Kempken (FK) (Fungal genetic and molecular biology) offer the unique combination to realize the fungal taxol biosynthetic potential. Overall, this research will lead to a comprehensive understanding of the key TFs that control elicitor induced metabolic changes to produce highest yield of fungal taxol and will provide intellectual property (IP), technology development, which lead to Dr. Kamal with new and cutting-edge research training.


**Keywords:** Taxol biosynthesis, Transcription factors, Elicitor, Endophytic fungi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SCIENCE-POLICY INTERFACES FOR BIODIVERSITY: RESEARCH, ACTION, AND LEARNING' (SPIRAL), addressing dissemination and exploitation.

assistant: **Impact**

SPIRAL aims to enhance the connectivity between biodiversity research and policy making. Although conservation and the sustainable use of biodiversity are fundamental requisites of human well-being, the biodiversity issue raises unprecedented challenges regarding science-policy interfaces. The project proposes state of the art interdisciplinary research on science-policy interfaces for sustainability governance at the theoretical, methodological and practical levels. This will support the design, implementation and operation of the ""real-life"" institutional designs that are currently emerging to interface biodiversity research and sustainability policy. The project will also provide an opportunity for the main actual or potential policy actors and stakeholders in biodiversity science-policy interfaces to learn, share experiences and network. SPIRAL will deliver a series of practical products for the benefit of users involved in interfaces, including workshops, networking opportunities, handbooks, policy briefs, targeted synthetic reports, an internet pilot platform, and a dedicated website. Overall this will allow scientists, policy-makers and other stakeholders to capitalise on a better understanding of science-policy interfaces and implement better practices.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanisms of Chromatin-based Epigenetic Inheritance' (EpiMechanism) under Seventh Framework.

assistant: **Objectives**

Epigenetic mechanisms heritably maintain gene expression states and chromosome organization across cell division. These include chromatin-based factors that are propagated independent of local DNA sequence elements, and are critical for normal development and prevent reprogramming, e.g. during induction of pluripotency. We focus on the role of nucleosomes, the histone-DNA complexes that make up chromatin. While prominently implicated in epigenetic memory, how histones and their local modifications can actually be inherited is largely unknown. We take aim at three fundamental aspects that we argue are central to this problem: stability of the epigenetic mark, self-templated duplication, and cell cycle coupling.We developed a unique pulse-labeling strategy to determine whether silent and active chromatin can be inherited and how this relates to transcription, both in cancer cells and in vitro differentiating stem cells. By coupling this strategy to an imaging-based RNAi screen we aim to identify components controlling nucleosome assembly and heritability. We achieve this by focusing on the human centromere, the chromosome locus essential for chromosome segregation which serves as an ideal model for epigenetic memory. This locus is specified by nucleosomes carrying the histone H3 variant, CENP-A that we have previously shown to be highly stable in cycling cells and to be replicated in a strict cell cycle coupled manner. We build on our previous successes to uncover the molecular mechanism and cellular consequences of the coupling between CENP-A propagation and the cell cycle which we postulate, ensures proper centromere size and mitotic fidelity. Furthermore, by genome engineering we developed a strategy to delete an endogenous centromere to determine how centromeres can f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Intrusion Detector Testing (IDT) - Development of methods and equipment for the measurements of the response threshold of volumetric intrusion detectors' in the context of a Fourth Framework call.

assistant: **Objectives**

The objective of this project is to develop a suitable test method and to design and produce the associated apparatus.Clearly the successful results of this project will benefit standardisation bodies and manufacturers by providing a means for more accurate assessment of detectors. It will provide product manufacturers with a faster route to the market place, by avoiding unnecessary duplication of tests at different laboratories. This in turn is likely to reduce costs and increase exports.Mid 2000 the IDT project have manufactured the first Prototype of the Intrusion Detector Testing Apparatus and the equipment has started its travel amongst 3 partner sites, where a benchmark testing and evaluation of the model are carried out.End 2001 it is planned that the Stability Test Apparatus will be commercially available to Test Houses as well as to Alarm Detector manufacturers. aBackground: On account of the rapid increase in crime, the number of installed intrusion alarm systems have risen sharply in recent years. The total number of detectors manufactured in Europe per year is approximately 5 million amounting to a market value of 200 MECU. The value of items being protected by such systems exceeds this value many times. However, there is a definite lack of consistency in the requirements between the national standards and vastly differing test methods, none of which could provide an adequate level of reproducibility of type approval testing of volumetric intrusion detectors. Objectives The objective of this project is therefore to develop a suitable test method and to design and produce the associated apparatus, which can be prescribed in the EN standards being prepared by CLC/TC79-WG2.Clearly, the successful results of this project will benefit standardisation bodies and m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Large scale system approach for advanced charging solutions', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The number of battery-powered electric vehicles is expected to be at 30-40 million by 2030 in the EU. This strong increase of electric vehicles is a big challenge for the energy system in Europe, but at the same time a chance to use V1G/V2G/V2X-technologies. As vehicles are mainly parking, they can be used as energy storage in order to increase grid stability.The overall project objective is to optimize the entire charging chain - from energy provision to the end user - to create a clear benefit for all stakeholders. Therefore, a ubiquitous on-demand charging solution based on an optimized charging network considering human, technical and economic factors along the entire charging chain shall be developed. The investigation of the user behavior as well as the analysis of the energy system and grid will form the basis from a research side, to predict the future behavior of EV owners and fleet operators as well as possible shortcomings in the electric grid and energy system. The development of advanced charging technologies and control mechanisms as well as advanced charging and sector coupling concepts, will form the basis for the virtual and real evalulations/demonstrations conducted in 4 different European countries (Belgium, Germany, Italy, Portugal). In parallel a smart charging simulation environment (digital twin of the charging chain with a holistic simulation environment with multilevel component models and representative information flow between all agents) will be built up. This digital twin will incorporate the results of the demonstration actions and enable an upscaling to show the impact of these technologies. To ensure the interoperability and the optimization along this charging chain, the consortium comprises all relevant partners/stakeholders (energy pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Expanding our knowledge on Citizen Science through analytics and analysis' (CS-Track) targeting Horizon 2020.

assistant: **Abstract**

The Call focuses on Citizen Science (CS), understanding it in a comprehensive way and inviting projects to deepen and broaden our knowledge on CS activities and their impact. Indeed, overcoming present hurdles on the way to reach that knowledge will enable the potential benefits of CS – on individual citizens, organizations, and society at large – to be realized more effectively and frequently. This is the aim of our proposed project, CS-Track, which will seek this increased knowledge by “observing” a large and diverse set of CS activities, gathering data from the web, interviews of involved players, etc., and from a more direct inspection of running activities. Vast amounts of data will thus be studied, relying for this on (1) web-based analytics, i.e. the use of computational analyses to study CS activities based on their manifestations and traces on the web and social media, and (2) deepening and combining these analyses with approaches known from social studies through multi-perspective analysis and triangulation. Our data analytics and analysis will target both “own” aspects and developments of the CS activities (organizational/operational characteristics, scientific outcomes, good practices, individual/group learning, other success or failure indicators, etc.), and societal aspects, related to the impact of those activities on society,  such as gender, age, geographical and socio-economic differences; science as a discipline and its role in society, changing attitudes to science, women in science, etc. This will enable us to understand complex processes, disseminate good practices and formulate knowledge-based policy recommendations intended to optimize CS to make it a major, positive factor for EU’s society and economy. The project will last 36 months, involving
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Rhodoshop – a pilot programme to facilitate investment in energy efficiency by creation of One-Stop-Shop in Rhodope Region of Bulgaria.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Rhodoshop project aims at assisting local public authorities and other stakeholders in small sized rural municipalities in Rhodope Region of Bulgaria in successful launching and implementation of sustainable energy projects. The project focuses on creation of a pilot programme for financing investment by establishing Rhodoshop Programme Development Unit (PDU) - a structure to act as central procurement agency on behalf of local authorities to undertake energy retrofitting works in their buildings and street lighting systems. Rhodoshop PDU represents innovative financing model of One-Stop-Shop replicated in Rhodope/Bulgarian context, focused on building investment project pipelines that will combine/bundle suitable projects in the subscribed municipalities (currently six with the possibility to include others in the course of work) in order to gain critical mass and get better financing terms. After accomplishing the pipe-lines respective public tenders will be launched in compliance with Green Public Procurement principles in order to make the best choice of environmentally friendly, energy efficient and cost effective products and services. Within its 48 months pilot phase Rhodoshop PDU will mobilize 7.067 MEUR investments for energy efficiency improvements in 32 public buildings and 0.660 MEUR investments for refurbishment in street lighting networks in 31 settlements of Rhodope Region. The energy savings resulting from the action are assessed to  11.276 GWh/year.


**Keywords:** financing energy efficiency facilitation local authorities municipalities Bulgaria
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'RHINOS - Railway High Integrity Navigation Overlay System will define a GNSS-based system to support the localization of trains respecting the challenging requirements of the railway safety standards.'.

assistant: **Innovation**

RHINOS aims at increasing the use of EGNSS to support the safety-critical train localization function for train control in emerging regional and global markets. RHINOS adds value to EGNSS by leveraging the results from prior or existing projects, and develops a Railway High Integrity Navigation Overlay System to be used by the rail community. RHINOS pillar is the GNSS infrastructure realized for the aviation application with additional layers that meet the rail requirements in the difficult railway environments. RHINOS will feature an international cooperation with the Stanford University that has been involved in the aviation application since the birth of the GPS, gaining an undeniable knowledge of the GNSS performance and high-integrity applications. The ambition is a positive step beyond the proliferation of GNSS platforms, mainly tailored for regional applications, to favor a global solution to release the potential benefits of the EGNSS in the fast growing train signaling world market. The RHINOS work programme includes the investigation of candidate concepts for the provision of the high integrity needed to protect the detected position of the train, as required by the train control system application. The EGNSS (GALILEO and EGNOS) plus GPS and WAAS constitute the reference infrastructure that is available world-wide. Moreover, local augmentation elements, ARAIM techniques and other sensors on the train are the add-on specific assets for mitigating the hazards due to the environmental effects which dominate the rail application. A further objective of RHINOS is to contribute to the definition of a standard for the Railway High Integrity Navigation Overlay System leveraging on the EU-US Cooperation Agreement on ARAIM. The RHINOS dissemination plan includes three s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mechanisms to Attack Steering Effectors of Rheumatoid Syndromes with Innovated Therapy Choices' (MASTERSWITCH), addressing dissemination and exploitation.

assistant: **Impact**

Objective: To delineate the biological and molecular pathways that initiate and drive chronic inflammatory disease and to transform the knowledge obtained into the development of novel anti-inflammatory interventions. Focus will be given to Rheumatoid Arthritis (RA) since longitudinal data indicate that intensive treatment can prevent persistency and chronicity.    State of the Art and beyond: The first generation of targeted therapies in chronic inflammatory disease used RA as prototype disease for clinical development. These therapies are now also used in other inflammatory disorders. Although treatments have been developed that are effective in a proportion of patients, they are aspecific, relatively toxic and do not mediate cure. Currently, it is unknown which molecular effects need to be induced and/or targeted to prevent induction or persistency of RA. However, this is within reach through a strong international consortium of world-leading European groups that cover both basic- and translational research.  Work plan: The general strategy for the project is to enable parallel studies that are focussed on critical switch moments in the biological processes that drive chronicity of inflammation. As the consortium consists of a multidisciplinary team with basic- and clinical expertise, translational research will be conducted to delineate the molecular basis of dysregulated inflammation, the RA-specific autoimmune-response and organ specific pathobiology.  The final aim is to develop novel- and specific anti-inflammatory therapies.  Impact of the project: This project will (i) identify the molecular networks underlying chronic inflammation and thereby (ii) will define novel targets for drug-development as well as (iii) algorithms that will predict outcome of therapy.