RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Program for Innovative Global Prevention of Streptococcus suis.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Streptococcus suis is an endemic porcine disease causing causing significant economic losses to the pork meat production industry in all countries where pigs are reared on a large scale. In some countries S. suis is the primary cause of mortality and morbidity in young pigs and the most frequent reason to prescribe antibiotics of the amino-penicillin group as a preventative measure. S. suis is also a zoonotic pathogen of humans and infections reported worldwide has increased significantly in the past years. Within S. suis many different types (serotypes, genotypes, pathotypes) exist causing problems in the development of control strategies targeting all types. Asymptomatic carriage in adult pigs is common and combined with a lack of knowledge on the host-pathogen-environment interactions, are the main reasons for failure to control the endemic nature of this pathogen.  The project outputs will impact on on understanding host-pathogen-environment interactions of S. suis infections through the genome sequencing of 1200-1500 S. suis isolates from representative geographic areas of the major pork producing countries and performing genome-wide-association studies with invasive disease and asymptomatic carriage. New diagnostic methods will be developed for global monitoring of infection risk and tested on case-farms. Epidemiology studies will determine risk factors for invasive S. suis disease, including the role of co-infections, and for the first time properly assess the dynamics of the disease on a representative farm. We will increase our understanding of the virulence mechanisms involved in pathogenesis including interactions of S. suis with the innate immune system. The project outputs will strengthen the evidence base for prevention and control strategies through testi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Experimental and Computational Tools for Combustion Optimization in Marine and Automotive Engines', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

ECCO-MATE aims to create a research and training platform for the development and implementation of novel fuel mixture preparation, injection profiling, air management and staged/low temperature combustion technologies both in marine and light-duty automotive diesel engines. The marine (slow speed, large-sized, two-stroke engines) and land-transport (high speed, small-to-medium-sized, four-stroke engines) sectors share essentially the same strategic challenges, namely the implementation of energy efficient and fuel flexible combustion technologies, in order to improve efficiency and meet stringent emission standards. However, there is little established training and academic communication between the two sectors, despite the common problems relating to the fuel injection, ignition and combustion methodologies and potentialities of new – more environmentally friendly – fuels. ECCO-MATE bridges this gap by creating a platform for research output exchange between the two sectors on diesel engine combustion by coupling state-of-the-art flow physics and combustion chemistry with CFD tools and advanced optical diagnostics.The consortium comprises 16 key partners - 6 Universities, 5 major key-stakeholders from the marine and automotive engine industries and 5 associate partners - from 7 EU countries and Japan. The consortium processes multi-disciplinary expertise, strong interests and tradition in both sectors and the necessary critical mass to achieve the research and ensuing training activities that highlight synergies, complementarities and provide solutions to the addressed common problems of the two sectors. The comprehensive training program (academic and professional training, focussed dissemination activities, trans-national and trans-sectoral mobility) exploits the mu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SPRHOUT (Solar PoweRed Horticultural Off-grid UniT) – the first economically viable off-grid energy system to power horticultural projects, boosting the transition towards sustainable food provision' (SPRHOUT), addressing dissemination and exploitation.

assistant: **Impact**

There will be 2.5 billion more people living on Earth by 2050, dramatically pushing the need for agriculture to both increase food production and at the same time reduce resource-consumption in order to ensure a sustainable future for humanity. Greenhouse-based horticulture could highly contribute to this goal, thanks to its unparalleled benefits in terms of reduced use of water and higher quality and quantity of product with respect to traditional agriculture. Nonetheless, greenhouse facilities need both huge amount of electricity and gas to be operated, accounting for energy consumption of about 3.4 MTOE per year only in Europe, which pushed European policy-makers to promote renewable-based energy solutions for the horticulture sector among the priorities.SOLHO is a high-tech company incubated at Yes!Delft which developed an innovative and fully off-grid energy system called SPRHOUT, that uses solar energy to fulfil the energy needs of a greenhouse facility.SOLHO’s core innovation is a proprietary thermal energy storage system which allows round the clock operation of all other units, enabling 24/7 energy supply during the night or whenever the sun is not available. We plan to market our SPRHOUT units by 2021 in Europe, Africa and Middle East through a B2B approach, selling the SPRHOUT system to large global greenhouse manufacturers, which will act as EPC contractors. Three global leaders of advanced horticultural projects have already expressed their interest in our solution. The Phase 1 project will be a launch pad for the future commercialization of the system, enabling SOLHO to validate the SPRHOUT performances and the market opportunity in key areas, assess the process’ economic performance indicators, and refine the business plan to attract the future investment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The European Hydrogen Academy' (2021-2027) under Horizon Europe.

assistant: **Objectives**

HyAcademy.EU will capitalise on the investments already made by the European Commission and Member States in education and training activities. The consortium brings together representatives from multiple projects (Table 1), enabling previous outputs to be consolidated and exploited, maximising the Academy impact and reach.In order to realise its objectives, the European Hydrogen Academy will have achieved by midterm to-build and sustain a network of over 100 universities (The Network of 100) offering recognised qualifications, specialisations, and degrees in hydrogen technologies,-build and sustain a network of over 500 schools integrating hydrogen topics into their science teaching, including technical schools and colleges with more specific technical training, -create a network of 5 hands-on, physical training laboratories,-offer a portal to showcase and link the educational programmes available in the network and beyond, in order to supply prospective trainees with accurate and detailed information on training and career opportunities, with a minimum of 100.000 accesses to documents specialising in hydrogen topics,-provide free training materials across European languages to lecturers and teachers in order to enable educational staff to deliver the vast body of educational measures necessary, -develop and integrate novel (online) teaching methodologies into university, college and school curricula, and train educational staff to successfully employ these, and -create and implement an organisational structure and a successful business case allowing continuation of the project activities post-funding in establishing a European Hydrogen Academy spanning all levels and types of education and training.HyAcademy.EU will considerably contribute to the EU goals of offering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Regulation of Brain Macrophage Development and Function' (MADEFUN), addressing dissemination and exploitation.

assistant: **Impact**

Macrophages are part of the mononuclear phagocyte system and play critical roles in innate immune responses. They further exert crucial organ-specific functions to warrant tissue homeostasis. Most macrophages are long-lived and derive from embryonic precursors. The central nervous system (CNS) contains several macrophage populations, of which microglia are the most prominent and abundant population residing in the CNS parenchyma. Besides being implicated in CNS pathologies, microglia guide neuronal development, are critical for neurogenesis and contribute to the maintenance of tissue homeostasis. At the interface between the brain and the periphery reside choroid plexus, perivascular and meningeal macrophages (‘border-associated’ macrophages, BAMs). While they mostly also originate from embryonic precursors, the differentiation cues and their specific roles in development and in health and disease are poorly understood. Here we will delineate the spatiotemporal emergence of BAMs and microglia, the impact of the local microenvironment on their phenotype and function, and their role in brain development. We will further analyze the role of BAMs and microglia in physiological and neuropathological conditions (neurodegeneration, CNS infection and inflammation). We have recently described a novel ‘microglia-specific’ conditional mouse and we are currently establishing an inducible system to specifically manipulate BAMs. We will use these to genetically intervene in different cytokine signaling pathways in combination with fate-mapping in vivo. The proposed research project will provide a deeper insight into microglia and BAM biology and their functional specializations at different stages of life.


**Keywords:** Macrophage, Microglia, Brain, Development, Function
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mechanisms of epigenetic gene regulation by R-loops' to be submitted under Horizon 2020.

assistant: **Abstract**

The last decade has revolutionized our thinking about regulatory RNAs and yet we are still at the beginning of understanding their biology. One such challenge is presented by R-loops, prevalent DNA:RNA hybrids, which lie at the interface of different nuclear processes, including transcription, RNA processing, lncRNAs, DNA damage, chromatin, and neurodegenerative disease. Long-time considered a threat to genomic integrity, recent evidence indicates that certain R-loops can act as epigenetic gene regulators. The hypothesis is that nascent RNAs retained at their site of transcription may function as sequence-specific component of mammalian chromatin to shape gene expression. Notably, R-loops found at GC-enriched promoters are implicated in preventing DNA methylation and promote transcription, but how this might occur has remained obscure. In a breakthrough discovery, we identified the first epigenetic R-loop reader. This protein binds directly and specifically to DNA:RNA hybrids in vitro and in vivo, and mediates local DNA hydroxymethylation and demethylation via TET (Ten-Eleven Translocation) cytosine oxidases. Using the R-loop reader as a tool provides a unique entry point to address fundamental questions regarding mechanisms and regulation of the epigenetic function and biological role of these DNA:RNA hybrids. Applying genome-wide approaches and studying the biology of embryonic stem cells (ESCs), we will 1) systematically identify regulatory R-loops, 2) characterize their common features, 3) address how R-loops are decoded in ESC pluripotency and differentiation, 4) investigate how regulatory R-loops are erased, and (5) screen for additional R-loop binders/readers and characterize their epigenetic role.  The HybReader project will allow for ground-breaking discoveries
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Non-Linear Bayesian partition-modeling of the Earth's mantle transition zone' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The Earth’s mantle transition zone (TZ) is a complex region exhibiting mineralogical phase changes as revealed by sharp increases of seismic wave-speed near 410 and 660 km depth. The TZ is a key region for understanding how efficient is mantle convection to recycle chemical heterogeneities. Attempts to isolate the effects of temperature and composition on elastic properties have faced several issues. First, due to the imperfect seismic data coverage, the scales of thermal and chemical heterogeneities remain poorly constrained. Second, seismic and mineral-physics data suffer from large uncertainties, and the relation between seismic observables and in situ thermo-chemical parameters remains questionable. To overcome these limitations, this project will use a partitioning (multi-scale) approach to isolate the effects of mantle temperature and composition from comprehensive seismic databases. Using a Bayesian probabilistic framework, the experienced researcher (ER) will simulate the multi-scale physical properties of the TZ, confront the results with high-pressure mineral physics experiments and with predictions from mantle convective mixing models. The interdisciplinary approach of this project relies on using state-of-the-art numerical methods and high performance computing to answer fundamental questions in Earth Sciences. The uniqueness of the approach arises from quantifying in a probabilistic sense how conceptual mantle-mixing models fit seismic data. The skills developed during this project will re-enforce the competitiveness of both institutions to build seismic models, and to study the Earth’s deep interior. The expected researcher outcome is the re-enforcement of his research network; the benefit of a new environment to efficiently prepare articles and professors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advanced and New Simulation Methods in Vehicle Vibro-acoustics - Scientific Analysis, Experimental Verification and Development of Methodologies for the Industrial Application.' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

The EST project SIM-VIA 2 aims to provide training facilities and scientific supervision for young researches in the field of vibroacoustics for vehicles. The focus of SIM-VIA 2 is to motivate and encourage early stage researchers for scientific work in th is interdisciplinary field. The training facilities include latest facilities for computation and experimental testing. Specific workshops, courses and educational programmes are existing and planed respectively within this training centre. The aim is to t he predictive qualities of modells of different simulation techniques (FEM, SEA, BEM,..). Furthermore, complementary techniques should be introduced and improved (e.g. Wave Based Technique) as well as simulation modelling for new technologies (active layer s). Emphasis is placed upon the verification of the improved simulation models and enhanced techniques by advanced experimental methods. Hybrid and intergral techniques will be developed to enhance the predictive potential for industrial applications. SIM-VIA 2 is formed by a group of participating hosts, combining high education and research institutions as well as industrial enterprises in different countries of the EC including New Member States. Thus, the engineers will have the chance to participate in both the scientific reasearch work and the practical application of developed methods. They will profit from extended international knowledge in the field of simulation techniques and vibro-acoustic methodologies and will thus profit at the time they star t to work in the industry after their academic education. Furthermore, the industry will gain from the specific training of the young researchers for the requirements in the development of new and technologically improved products in the sensitive field of noi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Local New Energy Technology Implementation (LETIT)' (LETIT) targeting Sixth Framework.

assistant: **Abstract**

Europe is facing increasing difficulties in meeting the ambitious renewable energy, energy efficiency and climate change targets set over the past decade. This is despite the instigation of numerous Community and Member State projects, programmes and legislative drivers. One of the key reasons for these difficulties stems from the fact that much of the responsibility for or the-ground approval, licensing and implementation of initiatives rests at a local level, with local authorities and local investors, whose levels of awareness and priorities are diverse and governed by another set of drivers. Local authorities typically lack the essential tools and capabilities to identify opportunities for investment or for promoting investment in sustainable energy.The proposed Local New Technology Implementation - LETIT" project aims to address each of these needs in a systematic manner to promote investment in new technology to achieve Europe' s sustainable energy targets. It brings together energy sector and technology experts from six European countries, to work with key local- level stakeholders in the participating countries.The main actions are to:Assess local priorities and develop a framewoik for identifying and valuing local assets from a sustainable energy perspective.Engage key stakeholders, most particularly local authorities and investors, in defining and managing risk within a replicable European framework.Develop asset, technology, externality (benefits and costs) and risk matrices, which then form the basis for setting scenarios and modelling investment options under the project.Form local action plans that address key priorities of the local authorities, as identified at the start of the project.Through these actions, the project with develop the tools and the fra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cell-type specific features of serotonergic neurons in the raphe nuclei' to be submitted under Seventh Framework.

assistant: **Abstract**

Serotonin (5-Hydroxytryptamine, 5-HT) has long been known to be involved in a variety of behavioral, cognitive and emotional processes and is commonly pharmacologically targeted in the treatment of some major psychiatric and neurological diseases. Most of the brain 5-HT innervation arises from a specific neuronal network in the brainstem, the raphe nuclei RN. For a better understanding of the brain 5-HT functions an in depth knowledge of RN network is required with a special emphasis on the activity of 5-HT neurons, since these can be directly linked to 5-HT release. Despite great interest in 5-HT function, relatively little is known about the activity of 5-HT cells in relation to behavior mainly because technical difficulties in identifying the neurochemical identity of the cells recorded. Here we propose an optogenetic approach which will allow us to to identify the neurochemical and anatomical identity of neurons recorded in behaving animals. In combination with specific behavioral paradigms, these experiments could provide insights into novel aspects of 5-HT function. The results obtained could have important pathophysiological implications.