RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'CRYSTAL CLEAR: determining the impact of charge on crystal nucleation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

All of the crystals that form in water on Earth are formed through reaction between oppositely charged ions. In these crystals, the ions are present in an ideal, charge-balanced ionic ratio. In contrast, the natural solutions in which they form, contain widely diverging ionic ratios. When crystals nucleate from natural solutions, they will be charged, and charge has a massive impact on the behaviour of small new crystals. Most nucleation experiments have been conducted in solutions with charge-balanced ionic ratios. This leads to uncharged crystal formation, which can be described with nucleation theories based on uncharged gas condensation into droplets. My pilot data show that this does not apply when ionic ratios diverge. New crystals then form and grow much slower than expected. Similarly, in natural solutions, crystals are often expected to form, but they do not, and vice versa. Clearly, we still have no idea how, why and how fast crystals nucleate in Earth surface environments. In this project, I will test the hypothesis that ionic ratio has a dramatic impact on nucleation: crystals will be charged, and this charge will determine their size, how and how fast they grow, aggregate, and transform.I will conduct state-of-the-art experiments and analyses that will provide in situ knowledge of the impact of ionic ratio on the charge, size, growth, aggregation and transformation of nuclei. Experiments will be complemented with advanced modelling to derive charged-nuclei stability and surrounding water properties. The results will be assimilated in a new crystal nucleation theory. CRYSTAL CLEAR will focus on barite, calcite and pyrite as examples of highly relevant Earth Materials. The outcome will be improved geoengineering options such as drinking water production and C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Selective glycoimmuno-targeting for cancer therapy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Immunotherapy recently became an important alternative to conventional treatment regimes, yet cancer remains a universal leading cause of death. Thus, novel cancer theranostic approaches are still much desired. Although altered cell surface glycosylation is one of the hallmarks of cancer, targeting this ‘sweet aim’ for cancer therapy has been elusive, largely due to carbohydrates poor immunogenicity and the low affinity of antibodies against them. A red meat-derived carbohydrate antigen is a novel immunogenic moiety providing a key to unlock the theranostic potential of tumor-associated carbohydrate antigens. This foreign non-human sugar can be acquired only through the diet and subsequently appears on diverse cell surface glycoconjugates as ‘self’, accumulating mostly on carcinomas, and resulting in a polyclonal xeno-autoantibodies response. I have shown that such antibodies have both diagnostic and therapeutic potential, although basic understanding of their specificity and potency is scarce. The primary objective of this proposal is to design a novel personalized cancer therapeutic approach based on xeno-autoantibodies against the dietary sugar antigen. We propose an innovative interdisciplinary approach crossing the boundaries of cancer research, glycosciences, immunology and nanotechnology, with cutting-edge technologies, to design, engineer, screen and fully investigate potent targeting of ‘SweetAim’ moieties. Our discovery line is based on a two-arms platform to generate optimized antibodies for passive/active therapy, together with refined tumor cells through glyco-engineering/reprogramming for unveiling novel theranostics, finally evaluated both in vitro and in vivo. I expect our groundbreaking achievements will lead to promising new clinical tools, particularl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Public awareness on sustainable high - technologies' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

According to the general perception of the science and technology development the public is confined to the role of the passive recipient, without any control or influence on the technology trends and research priorities. Innovation benefits suddenly occur without considering the general consensus or the social consequences they may cause. In this framework, P.U.S.H. project aims at developing a social Communication Methodology relying on an Internet-based platform enabling for a direct and in real time consultation of the public on specific issues, simultaneously delivering, in a direct and easy to access way all those relevant information, outstanding opinions, current controversies while highlighting ambiguous aspects which are the basis for a constructive and conscious dialogue.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Smart Reconfigurable photovoltaic modules for Building Integrated PhotoVoltaic applications' in the context of a Horizon 2020 call.

assistant: **Objectives**

The use of PhotoVoltaic (PV) modules in the built environment has rapidly been growing during the last years, especially in Europe. Building Integrated PhotoVoltaic (BIPV) modules cannot always be placed under ideal circumstances due to restrictions arising from the building profile. Therefore, non-ideal orientation and inhomogeneous irradiation resulting from shadowing from obstacles will often create non-uniform illumination. This, in turn, creates current mismatch among the different PV modules as well as among the different cells each PV module is made of. This mismatch can cause a dramatic reduction of the overall PV module power. Since current PV module technologies, both standard and smart, are not able to efficiently and effectively face the mismatch issue in highly non-uniform applications such as BIPV, innovative PV module technologies are required. The aim of this proposal is to realize a first fully functional demonstrator of Reconfigurable Smart PV (RSPV) module, able to dynamically change the electrical interconnection between the PV cells in real-time as the PV module adapts to its environment, and to develop the integrated intelligence. Both hardware and software will be designed ad hoc in order to balance additional cost and energy harvesting in non-ideal conditions. Such a solution will increase the energy harvesting in BIPV applications, where non-uniform operating conditions often occur.


**Keywords:** Photovoltaic energy, Power converters, Reconfigurable architectures, Maximum Power Point Tracking
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Implementation of new machine learning algorithms for the optimisation of drug formulations' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Correctly developing and predicting crystalline forms with specific physico-chemical properties is essential to the pharmaceutical industry. The main challenge this industry faces is the fact that most active pharmaceutical ingredients in most drugs can interconvert into a different (usually more stable) polymorph, potentially reducing the solubility of the drug, slowing down the release of the API and affecting the pharmacokinetics, bioavailability and efficacy of the drug. For instance, due to the complex interplay between thermodynamics and kinetics, it often happens that unexpected polymorphs emerge either in development (best case scenario) or long after the drug has been approved for market (worst case scenario). A previously known stable form that disappears or the sudden appearance of an even more stable form can have grave consequences. For instance, the new form may have new properties that are not suitable for the intended purpose of the drug, leading to significant economic and public health repercussions. This ERC Proof of Concept project aims to implement new machine learning approaches that would allow to accelerate the process of predicting crystal structures by a factor of 100, thereby making it sustainable and enabling industry to investigate other crystal structures of the same drug to find the most suitable formulation (e.g. hydrates, salts, co-crystals, etc). Beyond pharma (which is our target application for MACHINE-DRUG), polymorphism of chemical structures has significant importance across many other different industries. For instance, the polymorphism of a pigment can generate a different colour, or the polymorphism of a chemical structure can lead to a material with significantly different properties (thermal, plastic, etc.). As such, MACHINE-D
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The cardiovascular consequences of endurance exercise', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Problem: Exercise training represents an attractive and low-cost strategy to improve cardiovascular health. Recent studies, however, report novel evidence that endurance exercise can lead to potentially detrimental cardiac maladaptations. First, acute exercise-induced elevations in cardiac troponin (cTn) levels have been found, which typically reflect myocardial (micro-)damage and are predictive of future cardiovascular events and mortality. Secondly, myocardial fibrosis has been reported in 12–50% of individuals engaged in lifelong exercise training, reflecting scarring of cardiac tissue that is typically found in patients with cardiovascular diseases (CVD). These cardiac maladaptations are highly unexpected and largely unexplained in apparently healthy individuals.CARDI-ACHE: Based on the latest scientific insights, the overall aim of this proposal is to elucidate the clinical importance of exercise-induced cTn elevations and myocardial fibrosis in endurance athletes. Better understanding of the clinical relevance of these adaptations is important to differentiate between the beneficial and the potentially harmful effects of exercise. Accordingly, I will study the following scientifically and clinically relevant questions: I. What is the prognostic value of exercise-induced cTn elevations?II. What are the functional consequences of myocardial fibrosis and are these mediated by lifelong physical activity?III. Do exercise-induced cTn elevations contribute to the development of myocardial fibrosis?Relevance for science & candidate. With this project, I will use the most technologically advanced approaches and tools to understand the clinical relevance of potential cardiac maladaptations to exercise training. The studies are performed in a world-renowned research group wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Therapeutic immunization for HIV/AIDS', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Beyond the huge public health implications, the HIV/AIDS epidemic is now threatening economic growth and national security in many countries, with worldwide implications. Although highly effective drug therapies have been a major breakthrough, the limitations of life-long continuous treatment are becoming apparent and these therapies are limited to patients with access to these drugs. Prophylactic vaccines are not expected to be available before 2010 and could only control infection. Hence the needs to develop Therapeutic Immunizations, which can boost the patients' own specific immune response to help control vire replication. Immunization with such a vaccine is an attractive strategy for treatment as it is simple, feasible on a global scale, and can be combined with drug therapy.The Commission has recognized this and has made support available for European research in this field, but much of the expertise and intellectual capital is concentrated in large institutes in the USA. There is now a rare opportunity to attract a world-level expert, currently working in the USA, back to Europe to lead a European expertise centre on HIV infections. Prof Lisziewicz has worked at NIH with dr Gallo, one of the discoverers of the HIV virus, has established a leading Research Institute and is Professor at the renowned Georgetown University. Her grouphas developed an innovative therapeutic immunization program, which has been demonstrated in monkeys to work, and is now ready for the first clinical trials in patients. She has already established a small consortium to carry out immunological research, a clinical trial and obviously this program has even commercial exploitation potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Genome-wide identification of factors controlling the telomere damage response and telomere-driven genomic instability.' (TELOMERES).

assistant: **Innovation**

Telomeres are specialized nucleoprotein complexes that protect chromosome ends against recognition as DNA breaks. In somatic cells telomeres shorten every cell division, eventually compromising telomere function. This leads to activation of a DNA damage response that induces irreversible growth arrest or cell death and serves to suppress tumorigenesis by preventing outgrowth of incipient cancer cells. Furthermore, by limiting replicative potential, telomere dysfunction contributes to aging. However, deprotected chromosome ends are also subject to DNA repair activities that lead to chromosome end-to-end fusions. Upon cell division these fusions give rise to genomic instability through breakage-fusion-bridge cycles generating complex, unbalanced chromosome rearrangements. Cells with such instable genomes are highly prone to develop into cancer. The mechanisms underlying the telomere damage response and telomere-driven genomic instability are poorly understood. To increase our understanding of the cellular consequences of telomere dysfunction we will perform genome-wide functional genetic screens to identify factors with important roles in the telomere damage response and telomere-driven genomic instability. We will mechanistically study these genes for their role in the cellular response to telomere dysfunction. In addition, we will address if these factors act uniquely at telomeres or also affect the response to DNA lesions. Due to their unbiased nature these screens represent a unique opportunity to obtain highly novel and potentially unsuspected insights in the events following telomere deprotection. This work will lead to significantly increased mechanistic understanding of how dysfunctional telomeres affect genome stability, cancer development and aging, but might al
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Innovative eco-friendly activated carbon filters for harmful vapors & gases VOC purification' (CARVOC) targeting Seventh Framework.

assistant: **Abstract**

CARVOC wants to solve the social, environmental and economic problem that represents the emission of VOC/TIC to the atmosphere through the development of innovative activated carbon filters (ACF) based on activated carbons (AC) produced from natural wastes, capable of adsorbing VOC/TIC emitted by highly pollutant industries or that may be released in industrial accidents or in terrorist attacks.The resulting ACF will be primarily integrated into industrial filtering systems and personal protection equipments but may be included in all products whose purpose is the VOC purification. One of the project's goals is to decrease global air pollution.The wastes to be used for R&D of AC are the hemp residues from farming and industrial processing. They are a particularly suitable and novel raw material since hemp represents a sustainable crop with beneficial environmental characteristics not offered by other plants and it has many advantages for the preparation of AC mainly, large amounts of hemp residues are generated and its high carbon content.Different methods for the activation of the residues will be used for preparing AC with a suitable porous texture for gas and vapor phase pollutant abatement. There will be selected the most frequent and harmful VOC for the environment and with the greatest toxicity for Humans and Ecosystems. Adsorption tests will be carried out with the selected VOC, to determine the adsorption capacity of the AC towards those compounds, both in mixture or separately and, to evaluate the performance of the materials obtained.In CARVOC the SMEs will benefit from the R&D conducted by the RTDs, because it will be obtained an ACF with improved structural and functional features to existing AC on the market since it will be produced from a new precursor, h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ANTarctic Sea Ice Evolution from a novel biological archive' (ANTSIE) targeting Horizon 2020.

assistant: **Abstract**

Antarctic sea ice is a critical component of Earth’s climate system. Seasonal fluctuations support unique ecosystems and impact planetary albedo, ocean-atmosphere exchanges of heat and climatically-active gases (e.g. CO2), and formation of intermediate and deep water masses which create the world’s largest sink of heat and carbon. The properties of the sea-ice pack are complex: despite its climatic significance, Antarctic sea ice is challenging to observe and to model, leading to low confidence in future projections in a warming climate.The geological record offers a longer-term context for recent trends. At the last glacial maximum (LGM) a likely doubling of Antarctic sea-ice extent relative to today is hypothesised to have driven an ocean drawdown of atmospheric CO2. However, a combination of sparse empirical datasets and uncertainties in sea-ice modelling means that the properties and climatic impacts of the LGM Antarctic sea-ice pack are poorly understood. The narrow focus of the geological record on key primary producers and grazers further limits our understanding of Antarctic ecosystem responses to changes in sea ice.ANTSIE will exploit a unique biological archive of Antarctic sea-ice conditions to generate a novel ecosystem perspective on the patterns and properties of sea ice during and since the LGM. ‘Antarctic mumiyo’ sequences are preserved remains of regurgitated stomach contents from snow petrels, which feed within and at the edges of the sea-ice pack. A network of mumiyo sequences, which sample across the climatically important Weddell Sea region, will be geochemically analysed to determine snow petrel diet and sea-ice properties with unprecedented century-scale resolution. The results will be used to evaluate new state-of-the-art simulations of the LGM s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developmental pathway towards autonomy and dexterity in robot in-hand manipulation' (HANDLE) targeting Seventh Framework.

assistant: **Abstract**

The field of robotics is undergoing a major revolution as it is increasingly being applied to general purposes outside the production line: for health, rehabilitation and professional services, in domestic and leisure environments, as well as hazardous environments. There, one keystone for robots to carry out accurate and intelligent tasks, with and for people, is their ability both to handle autonomously all sorts of objects and to use human tools. However, today's robots are unable to achieve dexterous and fine manipulation, especially when this requires in-hand manipulation. They are far from being able to understand and reason about their environments, their goals and their own capabilities, to learn skills and improve their performance by what they have been taught and their own experience, to interact with their environments with the efficiency of humans.The HANDLE project aims at understanding how humans perform the manipulation of objects in order to replicate grasping and skilled in-hand movements with an anthropomorphic artificial hand, and thereby move robot grippers from current best practice towards more autonomous, natural and effective articulated hands. The project implies not only focusing on technological developments but also working with fundamental multidisciplinary research aspects in order to endow the robotic hand system with advanced perception capabilities, high level feedback control and elements of intelligence that allow recognition of objects and context, reasoning about actions and a high degree of recovery from failure during the execution of dexterous tasks.Integrating findings from disciplines such as neuroscience, developmental psychology, cognitive science, robotics, multimodal perception and machine learning, the method we will devel