RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structural and functional analysis of a novel family of transcriptional regulatory factors, the KRAB zinc finger proteins' (1994-1998).

assistant: **Innovation**

- To identifiy KOX zinc finger specific target sites and genes. - To analyse human zinc finger gene clusters on chromosome 10 p11.1-q11.1. - To map zinc finger genes to chromosomal loci. - To determine the structure of the KRAB domain and characterize proteins mediating KRAB specific repressor functions. - To generate knock-out mice with deleted zinc finger genes. - To evaluate the potential of transcription response modifiers in HIV infections.The identification and dissection of regulatory networks, which control the expression of human genes in space and time, would represent a breakthrough in both human genetics and developmental biology. Transcription factors of the Kruppel zinc finger type (ZNF) are nucleic acid binding factors which, due to the binding properties and organisation features of their finger domains, are each likely to bind to a small number of specific DNA sequences within the human genome. Furthermore, approximately one third of the 300 to 700 human ZNF genes contain a highly conserved protein domain (the KRAB domain), which is the strongest known repressor of transcription in any mammalian organism. The number, structure, biological activity and sequence conservation of ZNF genes studied in Xenopus and Drosophila indicates that they play a critical role in the control of gene expression. An important advance in our understanding of coordinated gene regulation will, therefore, be defining the precise function of specific KRAB zinc finger proteins in mammals and, in particular, in man. Significantly, once the function of one KRAB zinc finger protein has been conclusively determined, putative functions for other members of this huge family of transcriptional regulators can be assigned and investigated. In addition, this will enable the repression act
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A revolutionary I/O Planning Solution for  2.5D & 3D Nanoelectronic Systems Design'.

assistant: **Objectives**

HIPER is an advanced EDA (Electronic Design Automation) software for the optimization of I/O Planning of 2.5-D micro/nano electronic systems. This is an important enabling technology to assist in the design of 2.5D electronics and has been developed by MONOZUKURI S.p.A.  HIPER is capable of analysing, designing and optimizing the 2.5-D I/O planning of all electronic components (ICs, silicon interposer and package(s)) thanks to its software platform and revolutionary algorithms. This innovative solution will leverage a 30% reduction in the production costs, a 50% decrease in design lead-time, and an improvement in the overall product performance due to 65% reduction in wire crossing and 80% reduction in total connections length. The $7billion EDA market is dominated by three companies, Synopsys, Cadence Design Systems and Mentor Graphics. As a result of the work undertaken so far, in the 4th quarter of 2016 we started an official partnership with Synopsys where we have been granted access to their Physical implementation platform and we are currently working together to help two customers who are taping-out HBM-based 2.5D-IC.The solution, which is already backed by many prospective clients, targets major semiconductors companies, design houses, package manufacturers, and OSAT businesses, and is expected to be used by leading electronic companies in Europe (Italy, Germany, UK), ASIA, and USA within three years after its commercialization. The Global Electronic Design Automation market is expected to grow at a CAGR of 8.52% over the period 2016-2020 which provides an encouraging base for introducing new EDA tools. Moreover, HIPER perfectly serves the “Electronics Strategy for Europe”, adopted in May 2013 by the European Commission.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hydrogen As the Reducing Agent in the REcovery of metals and minerals from metallurgical waste' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

HARARE will demonstrate sustainable pathways to produce metals using hydrogen as an enabler, for removing waste and valorising materials in carbon free processes. The consortium’s concern and thus the drive to build this initiative, starts with an industry that is key contributor to a sustainable future: the metallurgical sector. The switch to renewable energies requires vast amounts of metals, such as steel and aluminium for solar panels and wind turbines, and copper for bolstering the electricity grid necessary for transport and industry. However, the metallurgical industry amounted to 70 million tons direct CO2 emitted in 2017. Moreover, carbon-based processes make the European metallurgical industry dependent on imports.Using hydrogen as a reductant to substitute carbon is one of the few ways metallurgical industry can potentially become truly free of CO2-emissions, utilizing raw materials that can be produced in Europe. HARARE’s vision is to tackle these challenges and become part of the solution, making the metallurgical industry more sustainable by presenting a circular concept that is based on a two-fold reasoning:1)Recover wastes with hydrogen. choosing two representative wastes from the copper and aluminium production processes, namely: flash smelter slag from primary copper production and Bauxite residue (BR) from aluminium production.2)Hydrogen-based processes will allow for an environmentally friendly metal industry while decreasing dependence from hard coal imports and being cost competitive. HARARE will thus eliminate waste from the metallurgical industry while recovering valuable materials, and increasing the use of hydrogen in the industry, thereby increasing its circularity, the utilization of raw materials and the profitability, lessening the negative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Promoting integrated transport in peripheral areas of the union. Case scandinavia', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

SCANDINET is designed to meet the requirements of Task 3.1/1 dealing with Integrated Transport Chains. Its overall goal to improve the access to the infrastructure, information and market for intermodal trasport services - in particular for SME's and isolated flows".To meet this goal, to study and to demonstrate these aims besed on PACT (Pilot Actions for Combined Transport) activities, the overall objectives of Project SCANDINET are:1. To identify the potential demand and supply for Intermodal Transport services, including line haulage, pick up and delivery for peripheral and isolated areas of EU.2. To identify the possibilities to combine national, inernational and transit flows into selected corridors and terminals by using Intermodal Transport.3. To study the possibilities toreduce the viable usage area of Intermodal Transport from 700 - 800 km and to combine the flows with new services. To build a framework for evaluating environmental and legal aspects of new IT services.4. To identify the gaps and bottlenecks in information in information flows. To define a concept for operational organisation for real time information services. A feasibility judgment of establishing new business to process information will be made.5. To validate developed concepts with simulation and field trials.6. To draw policy conclusions for peripheral and isolated areas. Design a guide for intermodal transport users and service providers. %3 to 4 corridors and transport concepts will be selected and tested during the course of the project. %SCANDINET will use the results of PACT activities"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Restoring Odorant detection and recognition in Smell dEficits' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Sensory deficits are a major source of handicap in people's lives. Scientists have already developed prostheses and implants for hearing impairments and are developing those for vision. Partial and total loss of smell (hyposmia / anosmia) impacts 20% of the world-wide population with deleterious effects on quality of life. However, we have yet to develop such devices to restore the sense of smell, primarily because scientific knowledge linking artificial systems to human biological olfaction is still lacking. Within Rose we envision such a long-term idea. Rose will generate new pieces of scientific knowledge that will be merged to construct a final proof of concept: the Digital Olfaction Module (DOM), a science-to-technology breakthrough enabling people with olfactory loss to perceive their olfactory environment. To this end, Rose will conduct ambitious interdisciplinary research: each partner will be assigned a specific role aligned with their domain of expertise and asked to push conventional boundaries. The Grenoble team (nanotechnology) will develop a new generation of miniaturized odor sensors. The Lausanne team (microtechnology) will develop a stimulation array. The Aryballe team (SME, biotechnology) and the Milano team (design and mechanics) will combine the sensors and the stimulators to design the DOM. The Dresden (neurosurgery), Thessaloniki (clinical olfaction) and Lyon (cognitive neuroscience) teams will test the DOM in humans with smell disorders. To the millions that suffer from hyposmia and anosmia, Rose will provide stepwise innovation previously unfathomed to overcome scientific and societal challenges and industrial competitiveness in the domain of sensory protheses.


**Keywords:** Sensory deficits, Human olfaction, Digital olfaction, CMUT Sensors, St
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European collaborative study on pregnant hiv-infected women and their children' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Vertical transmission rates in Europe have decreased with the recent widespread introduction of interventions such as anti-retroviral therapy, elective caesarean section delivery and no breastfeeding. However, these interventions and changes tithe management of adult disease raise new and complex questions. The European Collaborative Study is a prospective cohort study of children born to HIV-infected women, set up in 1987 to clarify issues relating to HIV infection in pregnancy and childhood. To date 2600 mother-child pairs have been enrolled from 22 centres in European countries. Continued enrolment and follow-up are proposed to explore these new questions, including the issue of adverse effects resulting from exposure to prophylactic antiretroviral drugs, the impact of such exposure on timing of diagnosis and natural history of infected children and the quality of life of affected families, and continued monitoring of vertical transmission rates
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Promoting Multi-Stakeholder Contributions to International Cooperation on Sustainable Solutions for Aquaculture Development in South-East Asia' (EURASTIP), addressing dissemination and exploitation.

assistant: **Impact**

EURASTIP will evaluate and prepare for the launch of an international multi-stakeholder platform (MSP), so as to provide a new mechanism to create and reinforce international cooperation on sustainable aquaculture between Europe and South-East Asia and will focus on actions that will provide mutual benefit to both regions. EURASTIP, headed by the European Aquaculture Technology and Innovation Platform (EATiP) will create and support 3 National Pilot multi-stakeholder Platforms (NPPs) in major aquaculture producing countries (Thailand, Vietnam and Bangladesh) and develop road-map models for others in the region, providing the foundation for an international MSP. It will create, develop and reinforce the networking needed for the promotion of B2B partnerships, using European and SE Asian networks, realising international brokerage events and promoting cooperation. EURASTIP will identify and address common standards for aquaculture site planning, animal health, food product safety and farm governance, supporting sustainable aquaculture development. Focus is given to reinforcing professional skills and competences in industry and research, using European and SE Asian education networks and industrial apprenticeship opportunities. The NPPs will develop vision documents, strategic research and innovation agendas (SRIAs), priorities and proposed actions; these will feed into EURASTIP impact measurement and including influence on national and regional policies. Attention is given to widespread dissemination actions, promoting EURASTIP in SE Asia and in Europe, encouraging a strong legacy position. URASTIP will provide recommendations and a plan for the establishment of an international MSP, covering its scope and operation further to the project timeline, leading to reinforced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Enhanced Ligase based histochemical techniques' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

A major future challenge in biology and medicine is to study biomolecules in their normal context in cells and tissues - in situ - to determine their sub-cellular localization, how they interact with other molecules and participate in signalling and control of cellular function in health and disease. The main purpose of this project is to develop new analytical procedures for the study of nucleic acids and proteins in situ, and to illustrate how they can enable novel biological studies for improved therapeutic targeting using cancer as the primary application area. The methods that will be developed are based on proximity ligation" and "padlock probing", which are the first technologies to meet this challenge and to offer the sensitivity and specificity required for detailed studies of single bio-molecules in situ. We will refine these technologies and develop a spectrum of reagents for the analysis of specific markers of particular interest in oncology. Furthermore, software and algorithms for automatic user-independent in situ image analysis of "digital" single molecule events will be developed. These methods, reagents and algorithms will then be used by scientists within the project to verify the value of such systems in biological studies. The assays will primarily be used in a research setting, but their utility in diagnostic settings will also be explored. A carefully selected interdisciplinary consortium of world class researchers and companies from several European countries are joining forces for the execution of this project. Four companies, of which three are SMEs, are taking leading roles in the project underlining the commercial relevance of the project. The results of the project will constitute an important foundation for products addressing significant m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ULTRAfast growth of ultrahigh performance SUPERconducting TAPEs' (ULTRASUPERTAPE) targeting Horizon 2020.

assistant: **Abstract**

ULTRASUPERTAPE aims to demonstrate an unprecedented approach for fabrication of low cost / high throughput / high performance High Temperature Superconducting (HTS) tapes, or Coated Conductors, to push the emerging HTS industry to market. The breakthrough idea is the use of Transient Liquid Assisted Growth from low cost Chemical Solution Deposition of Y, Ba, Cu metallorganic precursors to reach ultrafast growth rates. The key concept relies on the discovery of a tool to control the ignition effect of the transient liquid formation through the decomposition of barium carbonate even for thick films. The capability to modulate the transient liquid state with composition variations and low cost capital investment equipment enriches its potentiality. Innovative Additive Manufacturing and Digital Printing methodologies are identified to devise an integrated system able to address the full manufacturing process from solution deposition by ink jet printing to ultrafast epitaxial crystallization of the superconducting phase. A combinatorial chemistry strategy ensures fast screening operation. Furthermore, ULTRASUPERTAPE will boost Coated Conductor performances up to outstanding limits at high and ultrahigh fields, by smartly designing and engineering the local strain and electronic state properties of nanocomposite superconducting films. The digital-printing additive-manufacturing approach developed will be cleverly adapted to create unique superconducting nanocomposites from nanoparticle colloids with unlimited concentrations. This new instrument is foreseen to be transferable to many other functional applications of advanced nanocoatings, where long length or large area production of functional epitaxial films or multilayer structures are required. Consequently, wise ideas and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Efficient and accurate simulation techniques for free energies, enthalpies and entropies' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Computational, structure-based, drug design offers insight at an atomic resolution, which is commonly not attainable by experimental means. Detailed calculations on protein-ligand interactions help to rationalize and predict experimental findings. Accurate and efficient calculations of binding free energies is essential in this respect. In addition, knowledge concerning the enthalpic and entropic contributions are highly relevant to determine novel drug design strategies and to understand the underlying principles of ligand binding.Currently available methods to address ligand affinity either do not include all relevant contributions to the binding free energy, or are too computationally demanding to be applied straightforwardly. In addition, calculations on enthalpy and entropy for drug design purposes are very rare, due to the difficulty in calculating these accurately. This proposal describes the research that leads the way to new, standard applications to be used in drug design processes in academia and industry. Furthermore, we propose to investigate the enthalpic and entropic contributions to ligand binding. We define a ligand-surroundings enthalpy and entropy, which conveys more information than the experimentally accessible enthalpy and entropy of ligand binding.In support of this research, we will develop new enhanced sampling techniques which not only render the above calculations practically feasible, but which will also find their application in related research questions such as the protein folding problem or the elucidation of protein-protein interactions.The methods described are highly relevant for the pharmaceutical industry, where currently available computational approaches are insufficient to answer the questions of todays drug discovery programmes.