RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how '210pb and 137Cs as tracers of global circulation' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

RTD actions implementing ENRICH are part of accompanying measures of the Environment and Climate Programme, the Marine Science and Technology Programme and the International Cooperation Programme. CORDIS generally does not hold information on accompanying measures of RTD programmes. Therefore for further details please contact: Ib Troen, European Commission, DGXII.D.I at ib.troen@ec.europa.eu.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The values of French language and literature in the European Middle Ages' (TVOF).

assistant: **Innovation**

Two questions about linguistic identity lie at the heart of this project. What is the relation historically between language andidentity in Europe? How are cognate languages demarcated from each other? Normative models of national languageshelped shape Europe. Yet they did not become hegemonic until the 19th century. Indeed, they were imposed (not alwayssuccessfully) on a linguistic map of Europe more fluid and complex than most histories of national languages allow. In theMiddle Ages multilingualism was common, as was the use of non-local languages, notably Latin, but also French. Thisproject undertakes a revaluation of the nature and value of the use of French in Europe during a crucial period, 1100-1450,less in terms of its cultural prestige (the traditional focus of scholarship) than of its role as a supralocal, transnationallanguage, particularly in Western Europe and the Eastern Mediterranean. The project fosters collaboration between, andcuts across, different intellectual and national scholarly traditions, drawing on expertise in codicology, critical theory,linguistics, literature, and philology; it involves scholars from a range of European countries and North America, entailingempirical research around a complex and widely disseminated textual tradition vital to medieval understandings ofEuropean history and identity, L’Histoire ancienne jusqu’à César. This case study will ground and stimulate broaderspeculative reflection on the two core questions concerning linguistic identity. While the project builds on prior critiques ofthe construction of, and investment in, national languages and literary traditions, it has a broad historical scope, and willoffer an innovative, genuinely international perspective, in terms of both its object of study and method. Indeed,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A Minimal-Tag Bioorthogonal Labelling Approach to Protein Uptake, Traffic and Delivery' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The ability to probe dynamic cellular events that involve disease-associated proteins is limited, to a large extent, by the lack of development of a strategy that can use small coupling partners to react in chemoselective fashion with rapid kinetics that does not interfere with biological function(s) and localisation. In this application, I describe a conceptually new bioorthogonal-labelling approach that combines the introduction of a minimal non-canonical amino acid with chemoselective reactions, which display rapid kinetics, to label proteins in live cells. The small size of the new alkene-tagged amino acids, which will be genetically encoded, should not interfere with the protein’s innate structure, function(s) or localisation. Site-selective bioorthogonal labelling will be achieved through the use of a new photo-triggered [2+2] cycloaddition reaction with an alkene-bearing fluorophore and the known inverse-electron-demand Diels-Alder reaction with a fluorogenic tetrazine. Although the former offers potentially improved spatial and temporal resolution, the latter allows for turn-on fluorescence. The proposed new methodology will be applied in the context of a key cytokine involved in cancer progression. The ability to label this cytokine with minimal perturbation of its structure, function(s) and localisation will enable monitoring of its internalisation and intracellular trafficking pathways in cells that overexpress its receptor. In doing so, new insight into cancer biology will be generated that will inform the construction of safer, selective and more efficient protein-drug conjugates for targeted cancer treatment. The concept proposed here is designed to be generally applicable to label and study disease-associated proteins that are difficult to access by means
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Language switching and script mixing: multilingual landscapes of medieval Scandinavia'.

assistant: **Objectives**

The present project aims to investigate the encounter between the Latin and the native vernacular written culture in medieval Scandinavia, through phenomena of language and script switching in epigraphic sources. The spread of Latin is a pivotal point in the development of all European literate societies. Scandinavia represents a unique case study where Latin and the Roman script encountered and mixed itself with an 800 year old native tradition based on the local vernacular and the runic script. From being monolingual and monoscriptal, Scandinavia became multilingual and multiscriptal.Through an interdisciplinary framework to be developed in synergy with leading scholars at the University of Oslo, epigraphic methods completed by multimodal and sociolinguistic analyses within a linguistic landscape perspective will serve to determine: 1) the medieval writers’ multilingual and multiscriptal proficiency; 2) the status relationship between the Latin and runic written tradition; and 3) the ideological presuppositions and purposes of the use of different languages and scripts.For the first time, these phenomena will be studied systematically and through an unexplored combination of historical material and modern sociolinguistic methods. This will not only yield new insights in the multilingual literacy of medieval Scandinavia and on its underlying cultural and ideological aspects, but also in its significance in a European context. By embedding the Scandinavian case in the process of cultural and political formation of Europe, this project will also contribute to understand the common cultural heritage in modern European societies.


**Keywords:** Epigraphy, philology, multilingualism, linguistic landscapes, multimodality, runology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Computational Microscope on Molecular Binding: from atom to cell membrane scale'.

assistant: **Concept**

Molecular binding is a major research topic that has undoubtedly benefited of recent technological innovation, especially in the area of the so-called computational sciences. However, the predictive power of computations remains low mainly due to the poor correlation of the in-silico models with the real world. A clear example is drug discovery where the drug in vivo efficacy is seen correlated to the ligand residence time, which is hardly predictable by current computational methods. The present proposal tackles the challenge aiming at reshaping the border of the state-of-the-art simulations in molecular binding. I outline a research program that realises a vision where drug design is entrusted to ligand binding affinity and kinetics prediction, and molecular binding interactions are simulated in a realistic plasma membrane model. To achieve the ambitious goals of the research, my team will develop and apply cutting-edge computational techniques based on free-energy calculations, machine learning and multiscale molecular dynamics simulations. Evidence of the innovative nature of the developed approaches will be given by elucidating fundamental aspects of the functional mechanism of the G-protein coupled receptors (GPCRs), a pharmacologically prominent membrane protein family targeted by ~ 40% of marketed drugs. We will achieve a thorough characterization of the binding thermodynamics and kinetics of signal molecules (antagonists and agonists) that will be used by an original machine learning model to identify novel receptor antagonists with prescribed binding affinity and residence time. We will then investigate the receptor conformational transition from the inactive to the active state and develop an ad hoc multiscale approach to characterize the formation of GPCRs d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Deprogramming of the mammalian genome for stem cell production' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Cell based therapies potentially allow for alternative treatment of several human diseases. The search for an autologous cell source merits the investigation of novel means to de-program patient derived differentiated cells into pluripotent embryonic stem (ES) cells (or ES-like cells) with therapeutic potentials. The technique of cloning by somatic cell nuclear transfer (SCNT), where a differentiated somatic cell is transferred into an enucleated oocyte has now in several mammalian species proven that the oocyte possesses factors that can entirely de- and re-program the somatic cell genome.In this project, cytoplasmic extract of bovine oocytes obtained at the slaughterhouse will be used to de-program bovine and human granulosa cells into potential pluripotent ES-like cells. Recent data from the host laboratories indicate that the nucleolus can be used as a marker for genomic de-programming in conjunction with SCNT and that the de-programming effect of the oocyte is not species specific. Building on this back ground, we intend to use the nuclear and nucleolar architecture as well as markers of pluripotency of a somatic cell exposed to extracts from oocyte cytoplasm, to examine whether de-programming of the somatic cell genome is possible and to gain insight into the underlying molecular changes that are required to induce gene de-programming. This new knowledge generated in this research training project will constitute the basis for creating ES or ES-like cells for autologous cell replacement therapy circumventing the need for producing SCNT-embryos for ES cell derivation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'SolarGaps - Energy generating solar smart window blinds'.

assistant: **Concept**

With the constant growth of population in the world, the demand for electricity is rising. The biggest electricity consumers are buildings. In EU heating and cooling in the buildings and industry accounts for 50% of the EU’s total energy consumption. However, generating electricity from conventional sources of energy increases the greenhouse effect and escalate the environmental problems on Earth. One of the existing solutions to these problems are alternative sources of energy, in particular, solar. However, the existing solar solutions have several problems: solar panels are too expensive and can be mounted only on the roof or flat surfaces, and billions of city residents don't have access to roofs, or private land. Energy generation from vertical surfaces (such as solar window technology) is still on prototyping stage and has low efficiency. SolarGaps came up with the innovative solution – the company developed first in the world solar smart window blinds – a device that combines a shading appliance (venetian blinds) with solar panels, which allows generating electricity for further storage or use, as well as protecting the room from overheating, and the windows from poor weather conditions. The electricity, generated with SolarGaps, will allow to reduce external electricity consumption by up to 70% To ensure successful commercialization, in Phase 1 of SME Instrument, SolarGaps intends to develop an elaborate feasibility study for SolarGaps blinds commercialization that would include a thorough market research, dealership network development, a business plan with an extensive financial, pricing, and IPR strategy. This will help the company to have a more detailed vision of the target markets, improve the design and features of the product to meet the users’ needs, bu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Re/os systematics on oceanic cumulates' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content The Re/Os decay system is a new geochemical tool to study mantle processes. Its behaviour during magma formation and extraction is not well understood at the present time, due to the very specific chemical properties of these two elements (siderophile-chalcophile-lithophile). In a previous work, we have demonstrate the role of within-mantle cumulate crystallization to explain the systematically evolved chemical characters of MORBs (Mid-Ocean Ridge Basalts). In this project we attempt to use the same gabbroic suite found in the Oman ophiolite as a 'natural laboratory' to study and understand the Re/Os systematics during ocean crust formation. Special attention to Re/Os behaviour in melt extraction, migration and interaction processes should provide explanations to the observed Os isotopic disequilibrium between mantle residus and MORBs. This project is also hoped to provide a set of new high-quality data to geochemists who work on this particular isotopic tracer. Training content (objective, benefit and expected impact) The complete formation on Os separation technic (using the new chemical procedure), including test of yield, blanks, standarts plus analysis on selected samples should last 6 to 8 months. The last months will be used for the interpretation of Os isotopic signatures and the integration of these results in models of magma extraction and migration at oceanic ridges. Scientific objectives and benefits: The main objective is the understanding of the Re/Os behaviour during magma extraction from the mantle. Previous works on this topics have focussed on the analysis of oceanic lava or mantle residus. We think that the cumulates features of Oman could be a clue to understand the Re/Os systematics. Personal objectives and benefits:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Optimization and its Applications in Learning and Industry' under Seventh Framework.

assistant: **Concept**

The aim of our proposal is to enhance and extend existing networks with the goal to develop and transfer optimization models and solution techniques from theory to practice.Since this step is often neglected in academic optimization theory there is the need to motivate research by real world problems in order to bridge the current gap between theory and practice. Each of the participating  sites recognized that such a transfer is an important goal for the mutual benefit of researchers and practitioners. Each site has found pathways to overcome obstacles and to make optimization work in practice within their own national environment in many examples. We now want to join forces and learn from each other's expertise in order to jointly push the boundaries of optimization further towards practice in an international context.The goal will be achieved by a long-term cooperation in which we will share our knowledge about modelling, solving and implementing solutions to real-world problems within a continuing series of lectures, courses, seminars, and project works. In order to increase the impact of our cooperation we will in this proposal also focus on early-stage researchers and PhD students who will help spreading our ideas and techniques to industry and in this way contribute to a long lastingcooperation. Starting from case studies and project work which already has been done at any one of the participating sites we will identify new mathematical challenges stemming from real-world applications. This will enforce high-level research in these areas which will be carried out together with the participating PhD students on an international basis. In order to make our research results visible we will collect and publish case studies and project work and present the major resul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Earthquakes, tsunamis and landslides in the Corinth rift, Greece A multidisciplinary approach for measuring, modelling, and predicting their triggering mode and their effects.' (3HAZ-CORINTH) targeting Sixth Framework.

assistant: **Abstract**

The project will contribute to better measure, model, and predict the processes leading to earthquakes, andslides, submarine slides, and tsunamis, and their effect in terms of hazard. The target area is the rift of Corinth,well known for its exceptional activity with respect to these hazards. This work will focus on the western end of the rift, close to the cities of Patras and Aigion, where the risk is highest. We will study the short term seismic hazard with methods involving seismology, geodesy, geophysics, and geochemistry. In addition to strong motion analysis and prediction, transient processes (seismic swarms, ?silent? earthquakes, fluid transients) will be studied, for a better modelling  fault mechanics and earthquake preparation processes. In addition to the existing monitoring arrays and data base, specific new instrumentation will be built. Near-real time alarms systems for significant earthquakes will be developed and tested. For the long term seismic hazard, the seismic potential of active faults will be assessed on land and offshore. For submarine slope failures, places of past and future potential slumps will be mapped, and complemented by marine sediment coring and dating on selected places. Scenarios of slope failure and of coseismic displacement of the sea floor will be the inputs for tsunami modelling. The latter will be implemented using the existing high resolution bathymetry for modelling of the wave run up. Early warning alarms will be developed and tested. For landslid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biophotonic Nanoparticle-enabled Laser Blood Test for Early Detection of Pancreatic Cancer' to be submitted under Horizon Europe.

assistant: **Abstract**

Pancreatic ductal adenocarcinoma (PDAC) is a deadly form of cancer  that is on the rise due to various factors, including an aging population and unhealthy lifestyles. Regrettably, PDAC is among the top cancer killers, with a dismal five-year survival rate of less than 10%. The lack of adequate screening programs is a significant factor contributing to this dire statistic. However, the identification of PDAC in its early stages could help reduce the mortality rate by as much as 80%. The project LASERBLOOD (Biophotonic Nanoparticle-enabled Laser Blood Test for Early Detection of Pancreatic Cancer) aims to develop an in vitro diagnostic test based on the fluorescence lifetime fingerprint of the personalized protein corona, offering critical information at every stage of PDAC progression. The protein corona (PC) is a coating of bio-molecular substances surrounding nanoparticles when exposed to biofluids. It is both personalized and disease-specific, making it an ideal marker to monitor the variation of nanoparticle PC and correlate it to the development of PDAC. The analysis will use fluorescence lifetime (FL) analysis, a non-invasive, reactant-free, and real-time technique. In the initial phase, the consortium will utilize a mouse model (MKC) to identify the FL fingerprint of protein corona at each stage of PDAC development. The MKC mouse model is genetically engineered to be bioluminescent and develop PDAC in a controlled manner. By linking the development of PDAC observed through bioluminescent imaging to the FL response of PC in blood samples, the consortium will provide an unprecedented fingerprint of the disease's progression from its first occurrence. At a second stage, the project will validate on humans the use of the FL fingerprint of protein corona as a tool for