RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Audio-visual Streaming platform for domestic Leisure and Security', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

ASTRALS is a project focused on personalised, scalable, A/V encoding, transcoding/transrating, storage and distribution in existing households via streaming-optimised wireless links. ASTRALS motivation is to implement scalable solutions, which will enable a new beam of innovative A/V products and services including personalised, network aware video adaptation and distribution in multiple heterogeneous terminals (from low-cost PDAs to high-end home cinemas) and intelligent surveillance, utilising an in-home network. ASTRALS envisages a personalised, network agnostic, A/V architecture. A beyond state-of-the art Residential Gateway (RG) enhanced with A/V optimised and broadband wireless extensions will be the centre of ASTRALS home-centred A/V platform.Without excluding legacy network interfaces, ASTRALS will specify and prototype a streaming-optimised, IEEE 802.16 based, wireless platform as the major in-home distribution medium. MIMO and mesh technologies will provide for efficient home coverage and ad-hoc networking, with minimal administration requirements. In parallel, the RG will provide enhancements for A/V scalable/personalised encoding, transcoding, storage and distribution based on user/services profiles, content and network conditions. H.264 AVC and SVC, A/V transcoding/transrating and erosion-featured storage derived from personalised preferences, will be provided on a specialized fully programmable A/V platform.Moreover, content media adaptation and efficient transmission based on feedback from the wireless MAC and network layer will be implemented and validated. ASTRALS will eventually provide citizens with the means to build new personalized, A/V user-centric services (entertainment, healthcare, e-learning, home surveillance), improving their quality of life
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Sustainability Transition Assessment Rules for Bio-Based Systems' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

STAR4BBS is a three-year multidisciplinary and multi-actor collaborative project, involving seven partners, three associated partners and one linked third party. The overall aim of STAR4BBS is to maximize the potential of Sustainability Certification Schemes (SCS) and labels to support a successful transition to sustainable bio-based economy. At the core of the STAR4BBS project is the development of indicators and a new monitoring system for assessing the effectiveness and robustness of existing international and EU SCS, B2B labels, and related traceability systems applicable to biological feedstock and bio-based materials and products. This information will create the foundations to support achieving the much needed harmonization between schemes and transparency in global and EU trade flows. Through the developed new monitoring system, existing SCS and labels will be analyzed, and the results, as well as additional research on certified and uncertified trade flows and on the impacts and costs and benefits of certification and labels, will substantially increase understanding of the potential of these schemes to contribute to policy and industry sustainability goals and will build awareness of the differences between the schemes. The project will involve important stakeholders (including scheme owners, policy makers, and industry) in the design of research and the monitoring system and in the development of practical recommendations emerging from the research and analysis in order to ensure that the project achieves its ultimate goal. In particular, an increased uptake of the most effective SCS and labels by the bio-based industry will support the development of circular, climate-neutral,  sustainable biobased systems that will mitigate climate change, increase resource
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Genomic investigation of chronic intestinal inflammation (GENETICS OF IBD)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Inflammatory bowel disease (IBD) is a complex, polygenic disorder, which affects mainly young adults. Genetic linkage to susceptibility areas on chromosomes16, 6 and 12 has been confirmed in affected sib pair studies. The life-style of modern industrialised civilisations appears to be a strong trigger for disease manifestation. The applicants use their well-characterised collection of multiplex and monoplex families to identify the genes by systematic association studies utilising polymorphisms of genes in linkage regions. Gene-chip based expression screening (using acDNA array with 38,000 clustered ESTs, which is proprietary to the applicants) will be used to understand the function of known and novel genes in disease pathophysiology. Proteomics approaches are taken to understand the function of differentially expressed genes and for a systematic post expression analysis. Through a complex genotype-phenotype analysis the applicability of molecular findings to the population will be defined. This will result in a validation of molecular abnormalities as novel targets for therapy and/or as screening tools. Extensive statistical and epidemiological analysis will develop a disease model describe the interaction between multiple genetic and life style factors. The proposal will therefore produce exploitable intellectual property resulting in a substantial improvement...
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'An Internet Based Electronic Voting System', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The objectives of the project are to design, implement and validate an Internet-based electronic voting system that will provide the required services for organizing and conducting a voting process.The main functionalities that the e-VOTE system will support are ballot generation, specification of voting precincts, voters registration and credential validation, calculation of the vote tally and communication of candidate parties with the public.The system will be accessible through, mainly, conventional Web browsers, and WAP-enabled mobile phones. Furthermore, it will exhibit a Voting Protocol that can prevent opportunities for fraud or for sacrificing the voter's privacy, by implementing a wide set of security criteria and thus enjoying much of the trust and confidence of voters and process organizers.Personnel specializing on voting procedures, legal aspects, as well as on the sociological and behavioural aspects of such processes and systems will be employed for testing e-VOTE's acceptability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Single protein folding Pathways' under Sixth Framework.

assistant: **Concept**

This project aims at importing in Europe key scientific competences developed by the applicant researcher during a period of almost 10 years spent at UC Berkeley (group of Prof. Carlos Bustamante) working on the technique of laser tweezers applied to the study of folding/unfolding pathways of single proteins.The aforementioned group has pioneered the measurements of the tiny forces which allow a biopolymer to attain and maintain its native structure. Laser tweezers applied to protein folding, have the remarkable advantage of operating on a single molecule, avoiding the ensemble average typical of classical bulky techniques and providing naturally a reaction coordinate to follow the thermodynamic process of folding.We propose to build the double trap laser tweezers at CNR-INFM-S3 in Modena and to investigate the energy landscape of the folding trajectories of the protein RNaseH by:- estimating the activation energies between different molecular states along the reaction coordinate from the dependence of the folding rate constants on temperature;- determining the structures of the transition states through Phi-value analysis;- analyzing the anisotropy of the energy landscape by denaturing the molecules along different pulling axes, and- carrying out molecular dynamic simulations to gain insight into the microscopic details of the folding reactions.The results of these experiments should help elucidating the role of the energy landscape in determining the folding, dynamics and ultimately the function of a protein. The applicant researcher possesses all the needed capabilities to face this ambitious goal.The host offers in this sense an ideally suited environment for the prompt transplantation and successful development of this technique in Europe. By this action we would i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Automated Synthesis of Stochastic Cyber-Physical Systems: A Robust Approach'.

assistant: **Innovation**

Cyber-physical systems (CPS) are complex systems with tight interactions between cyber elements and physical components. The cyber elements are control algorithms implemented by computer-based software. Developing the embedded control software for CPS is currently ad hoc and error-prone, which has created costly undesired behaviours, particularly in safety-critical applications. Examples of such undesired behaviours include frequency deviation in power networks causing outages or blackouts (e.g., in Jan 2021 in EU, affecting 200k households), crash of airplanes due to software bugs (Boeing 737 Max, costs 15.9 billion euros) or autonomous cars having software bugs (Toyota recalled 65,000 cars in 2015). Nowadays, most of the costs of CPS design is spent on ensuring that the system meets all the requirements especially when it is working in uncertain conditions. In order to design reliable CPS and to reduce the costs of such a design, I propose a novel robust synthesis approach that computes automatically the control software from high-level requirements. This novel approach creates a paradigm shift in CPS design as it computes control software in a push-button manner and eliminates time-consuming, costly post-validation steps. The approach tackles the CPS complexity by developing new abstraction techniques that are compositional and robust to model uncertainties, which will be integrated in a unified framework for automating the design of the control software. This synthesis paradigm is founded on novel compositional similarity relations with coupled uncertainties and coupled computations on abstract models. My project is high-risk because it requires merging and re-thinking different design methodologies from multiple disciplines including control theory, computer scienc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Search for a sustainable way of exploiting black shale ores using biotechnologies' (BIOSHALE).

assistant: **Innovation**

The BIOSHALE project aims at evaluating biotechnologies for the safe, clean and viable beneficiation of black shale ores and at designing an innovative model of development of the mining activities, which addresses the relevancy of a biological approach, along with the evaluation of the environmental impact of the industrial exploitation of black shale ores, at all steps. European deposits of black shale ores contain considerable reserves of base and highly valuable rare and precious metals (Cu, Ni, Zn, Pub, Ag, Zn, Co, More, V, Se, Son, Bi, Au, Pt, Pd, etc.) of which Europe is the main consumer in the World, so availability assumes a strategic importance. Two major difficulties restrict the exploitation of such abundant resources. The first is the low efficiency of the conventional technical means for recovering valuable metals, from mining extraction to metallurgical processing. The second is the environmental impact of the application of the conventional techniques. The success of bio hydrometallurgy lies in the efficiency of the process with a reduced impact on the environment compared to conventional techniques. Bio leaching dissolves metals and a variety of chemical and electrochemical methods allow the selective recovery of each of the valuable metals and the transformation of the rest of the material into an inert waste. BIOSHALE will use an original and rational strategy based on a significant part of the tasks in every work- package of the project being systematically dedicated to the study of the role of biological phenomena from the processing and environmental points of view and to the environmental impact assessment, the social and economic benefits of this project in Europe would be to allow an extension of the exploitation life of European mining sites i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Oxidoreductases of the mammalian secretory pathway' (1998-2002).

assistant: **Concept**

The redox enzymes ErolL-alpha and Ero1L-beta play a central role in the maintenance of the Endoplasmic Reticulum (ER) by catalysing disulphide bond formation. Ero family proteins probably act byoxidising Protein Disulphide Isomerase (PDI), which in turnoxidises substrate proteins, enabling substrates to form disulphide bonds. Ero proteins are required for disulphide bond formation, however the substrate specificity of Ero proteins has not been addressed up until now. My project will ask the question:What is the substrate specificity of human Ero proteins and how is this specificity achieved?I would like to study the ER redox machinery by focusing on the MHC class I and II antigen presentation molecules. The components required for the oxidation of MHC molecules are largely unknown. Understanding the oxidation process of MHC molecules is very relevant as the binding of antigenic peptides to these important mediators of immunity requires properly folded molecules. In addition, I will address a number of specific questions:- Are Ero proteins involved in the oxidation of MHC molecules? If so, how do they catalyze this process?- What other (unknown) oxidoreductases or intermediates are involved in MHC class I and II oxidation ?- How does MHC class I oxidation influence peptide loading?- How is MHC class II and Ii oxidation coordinated in relation to Iiassociation? These experiments should result in an increased understanding of how oxidation of MHC class I and II molecules is regulated and coordinated. I hope to determine what proteins are involved and via what intermediates the formation of disulphide bonds proceeds. I will extend my expertise by coming to terms with novel techniques, especially proteomics, ultra-short pulse chase experiments and by establishing novel metho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A real-time slope stability and subsidence monitoring service to improve productivity and to prevent catastrophic events in the mining industry' (MOTIONMAPPER) under Horizon 2020.

assistant: **Objectives**

The mining industry is growing and is a key global economic driver, providing raw materials for consumer and industrial products, being Europe one of the most demanding regions of raw materials. Mining operations relie on large scale, continuing, and safe operations in and around geological sites, but with repeated accidents and non-complete monitoring of how operations are impacting the terrain, the issue is far from resolved.Disasters occur, such as collapses of mining slopes, or ‘tailings dams’ with a release of chemicals leading to loss of life, interruption of mining operations and catastrophic environmental consequences: a collapse of a tailings dam may destroy natural drinking water and rivers for centuries.DARES, a European company formed by staff with multiple years’ of experience in the industrial remote monitoring field wish to change this. We have been developing and commercializing an industry leading satellite-based remote monitoring solution. Now we are adding Drone, Ground Radar and near-realtime processing to generate a complete wide area to local area monitoring and alerting solution. Called MOTIONMAPPER 2.0, it represents a ground-breaking solution to ensure safety of operations and to guarantee operational efficiency.We are in a unique position to do this. We have both the academic and industrial skill sets, as well as monitoring contracts with several large mines operating our satellite-based solution. Following a successful phase 1 feasibility study, we propose a two-year project to fund the complex technical work and commercial entry preparations. Generating a new product category in a sector with clear demand, we predict sales of 22M€ by 2022, growth to 55 employees and a substantial impact on the protection of the environment as well as the Euro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mesocorticolimbic System: functional anatomy,  drug-evoked synaptic plasticity & behavioral correlates of Synaptic Inhibition' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The mesocorticolimbic (MCL) system, extending from the ventral tegmental area (VTA) to the nucleus accumbens and prefrontal cortex, comprises a dopamine (DA) projection implicated in reinforcement learning. The MCL system is the target of addictive substances and of drug-evoked synaptic plasticity, a cellular mechanism that may underlie the adaptive, pathological behaviors that occur after repeated drug exposure. While most previous work has focused on excitatory transmission, recent studies suggest that inhibitory transmission may play a crucial role in mediating specific functions of the MCL system. However the identity of the inhibitory synapses and circuits and the plasticity mechanisms underlying these forms of normal and pathological learning remain elusive. We hypothesize that distinct inhibitory circuits in the MCL system mediate specific behaviors and that adaptive synaptic plasticity of these circuits are fundamental to both normal reward learning and addictive behaviors.We will test this hypothesis using optogenetic projection targeting to characterize specific inhibitory projections, to selectively change the activity of these neurons in freely behaving animals to explore their behavioral relevance, and to identify precise circuit changes that underlie behavioral alterations after drug exposure. Taken together, the experiments we propose will not only identify the specific circuits and basic role of inhibition in mediating reward-related behaviors, but will allow us to understand how the alteration of these circuits after drugs can result in pathological behavior. Ultimately, our results will establish the importance of inhibitory synaptic transmission in the MCL system, are likely to fundamentally change current views of this important modulatory system, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Introduction of normal flora to infant gastrointestinal tracts' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

There is an increasing frequency of food allergy and intolerance in infants in the developed world. A substantial body of evidence suggests that this increase is due to the failure of the 'priming' activities of the normal flora of human intestinal tracts on the immature immune system in advanced societies. This may be caused by over hygienic conditions in hospitals, use of antibiotics and other modern techniques in infancy. This project aims to produce a nutritional supplement containing probation bacteria isolated from the bacterial flora of the infant gastrointestinal tract. These will prime the gastrointestinal tract to promote the optimal maturation of the infant gut mussel immune system and minimise subsequent allergic sensitivities. The project will thus enhance the health of infants suffering from food allergy and intolerance - an important section of the population. Research objectives are to identify key microorganisms; develop a product comprising these microorganisms; carryout safety testing and design and implement at least three clinical trials of the product before launching it in the marketplace.