RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mutational processes and impact of structural variants in somatic cells' (STRUCTOMATIC).

assistant: **Innovation**

Mutational processes that generate structural variants (SV) in human and other genomes are understudied and merit attention, and similarly so for the functional impact of the SVs on gene function and regulation.  SVs may explain some of the missing heritability in population studies, they may provide candidate pathogenic variants in pedigree studies of hereditary diseases, as well as constitute yet-undiscovered driver events that were anticipated from cancer genomics.  Reasons why the SV mutational processes and SV functional impact are understudied are both of a technical and a conceptual nature; both aspects will be addressed in the STRUCTOMATIC project.  We will study structural variation in human somatic cells by combining diverse computational and experimental approaches, drawing on a genomic resource of hundreds of tumors and healthy tissues sequenced using long-read WGS that we will generate.  We will further perform mutation accumulation and directed evolution experiments using cell line models of chromosomal instability, generating further genomic data that will support observational analyses of tumor genomes.  The project aims are: thoroughly cataloguing the diversity of SVs in multiple somatic cell types including those not detectable by short-read WGS, elucidating the underlying mutational mechanisms that generate SVs, their heterogeneity across the human chromosomes as well as their variation between individuals, and developing rigorous statistical methodologies for identifying positive and negative selection on SVs in human somatic cells.  Characterizing the landscape of somatic SVs is crucial for a more complete understanding of the genetic basis of carcinogenesis and of the variable cancer risk across tissues and individuals, and may also provide evidenc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Restarting the Economy in Support of Environment, through Technology'.

assistant: **Innovation**

Time is running out to achieve a more sustainable development.  Post COVID-19 economic stimuli need to deploy a green new deal (GND) that ReSETs economic systems to create secure and meaningful employment whilst protecting nature for people, for climate change and flood mitigation, temperature regulation, pollution prevention and soil and biodiversity conservation.  This green new deal needs to harness safe, renewable technologies and nature-based solutions.  A business as usual (BAU) post-COVID stimulus would embed employment, economic and environmental precarity in what is now fundamentally an unsustainable and unequitable model.RESET aims to leverage developments in spatial modelling, artificial intelligence and interoperable environmental sensing to better understand pathways to RESET agricultural and urban development across Europe for sustainability. For agriculture we will examine BAU versus an alternative trajectory of regenerative agriculture and rewilding.  For cities we will examine BAU vs a more telecommuting focused trajectory of  lowered densities, re-greening, traffic reduction to reduce (air, water, noise) pollution and improve the quality of urban life.  In all cases we will examine impacts on employment, environment and economy.We focus on farmland and urban land uses as understudied environments and as key for sustainable development. We will build upon the success of our previous work in developing spatial policy support systems and accompanying user-led design processes, to further develop and integrate advanced environmental sensor networks with a focus on per-person individualised employment, economic and environmental outcomes of investments. This will require environmental and social intelligence to an unprecedented degree bringing together envi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Unassisted photochemical water oxidation to solar hydrogen peroxide production' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The growing demand for clean energy, and serious nature of global warming are unquestionable. Moreover, the finite nature of fossil fuel reserves and the increasing pace of climate change mean that we must find and harness clean and sustainable energy sources. H2O2 can be one such energy source because it is one of the most potent fuels, generating more energy than any other fuel without generating any pollutant. Although the green hydrogen economy is projected as a solution to clean energy demand, it suffers from storage problems due to the low volumetric energy density in the gas phase. However, there is no storage issue associated with liquid form H2O2. Undoubtedly, the photochemical O2 reduction route has great potential for H2O2 production but the systematic requirements limit its commercialization. However, there is no photocatalyst reported so far, which oxidized the water to H2O2 without any assistance (without the use of a sacrificial agent, external bias, oxygen supply, etc.). This project USHPP (Unassisted photochemical water oxidation to solar hydrogen peroxide production) is designed to address all these problems by synthesizing a stable, shielded, and water oxidizing PC for commercially viable and eco-friendly H2O2 production route. Furthermore, the spontaneous reduction of H+ ions to H2 in conduction band in the proposed  USHPP project will resolve the major problem of gases separation associated with photochemical H2 production in powder system (as there will be two separate phases: H2O2 in liquid (oxidative product), and H2 in the gas phase (reductive product)). Further, the success of this project also opens the possibility of simultaneous production of H2O2 via H2O oxidation at valence band, and O2 reduction at conduction band, which will increase the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Low-cost all-polymer integrated circuits for low-end high-volume identification applications (PLASTRONIX)' (PLASTRONIX).

assistant: **Innovation**

There is a need for contactless readable electronic barcodes for identification and product tagging. The applications range from electronic article surveillance, identification tags for retail, anti counterfeit devices to access control, airline luggage tracking and recycling. Present transponders made with regular ICs are too expensive. A cost price reduction by an order of magnitude is required. Polymers are associated with low-cost due to their ease of processing. Recently, the first all-polymer integrated circuits and functional transponders have been realized. Apart from low-cost they offer considerable environmental advantages. The target of this 2 year research project is to design and control a manufacturing process for the polymeric semiconductor, and to develop an industrial process technology for flexible polymeric integrated circuits. This project will open the new emerging field of polymer electronics.- A reproducible process technology for all-polymer integrated circuits has been developed with acceptable process windows. The process is based on patterned films of polyaniline and photochemical via's .The process is based on a 150-mm batch technology. The technology is IC compatible. The technology could be demonstrated with high performance 15-bit polymeric code generators. The operational and shelf life time of the devices, at ambient conditions, are hours and months respectively;- The synthesis of the Wessling monomer could be scaled up to batches of 300 gram. Batches for the precursor PTV polymer could be delivered to the partners in sufficient amounts to test the new 150-mm IC line. The manufacture on a still larger scale is hampered by the physical form of the polymer, which is not yet not suitable for industry standard vessels and filtration equipmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Evolution and Transfer of Antibiotic Resistance' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Antibiotics are essential therapeutics in the treatment of bacterial infections. However, the indiscriminate use of antibiotics has led to the emergence of antibiotic resistant bacteria that pose a major threat to human health as options for treating infections by these bacteria have become limited. The evolution, emergence and spread ofantibiotic resistance genes are still only poorly understood and expanding our knowledge on these aspects will provide novel leads to combat the emergence of antibiotic resistance.The EvoTAR consortium gathers a multi-disciplinary group of leading European researchers in the fields of antibiotic resistance, microbial genomics and mathematical modelling. In addition, three research-intensive SMEs participate in EvoTAR, two of which are involved in the development of novel approaches to minimize the emergence and spread of antibiotic resistance.The purpose of EvoTAR is to increase the understanding of the evolution and spread of antibiotic resistance in human pathogens. EvoTAR will characterise the human reservoir of antibiotic resistance genes (“the resistome”) by investigating the dynamics and evolution of the interaction between resistant and non-resistant bacteria fromthe human microbiome and the interrelations of the human resistome with non-human reservoirs of resistance genes. Novel methods will be used to quantify resistance transfer under controlled conditions in gene exchange communities. Mathematical modelling will be applied to predict gene flow between different reservoirs and topredict future resistance trends. Novel in vitro and in vivo models will allow the study of the efficacy of novel therapeutics aimed at reducing selection and spread of antibiotic resistance.The EvoTAR project will generate novel insights into the evol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Variety, Veracity, VaLue: Handling the Multiplicity of Urban Sensors'.

assistant: **Objectives**

Urban environments are awash with data from fixed and mobile sensors and monitoring infrastructures from public, private, or industry sources. Making such data useful would enable developing novel big data applications to benefit the citizens of Europe in areas such as transportation, infrastructures, and crime prevention.  Urban data is heterogeneous, noisy, and unlabeled, which severely reduces its usability. Succinctly stated, urban data are difficult to understand. The goal of the VaVel project is to radically advance our ability to use urban data in applications that can identify and address citizen needs and improve urban life.  Our motivation comes from problems in urban transportation. This  project will develop a general purpose framework for managing and mining multiple heterogeneous urban data streams for cities become  more efficient, productive and resilient. The framework will be able to solve major issues that arise with urban transportation related data and are currently not dealt by existing stream management technologies. The project brings together two European cities that provide diverse large scale data of cross-country origin and real application needs, three major European companies in this space, and a strong group of researchers that have uniquely strong expertise in analyzing real-life urban data. VaVel aims at making fundamental advances in addressing the most critical inefficiencies of current (big) data management and stream frameworks to cope with emerging urban sensor data thus making European urban data more accessible and easy to use and enhancing European industries that use big data management and analytics. The consortium develops end-user driven concrete scenaria that are addressing real, important problems with the potential of enor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Omics integration for precision cancer immunotherapy'.

assistant: **Concept**

The development of immunotherapies based on checkpoint inhibitors marks the beginning of a new era in the treatment of cancer, with 20-30% of tumor response in advanced non–small-cell lung cancer and melanoma. However, the rational use of these agents has been limited by the lack of definitive predictive biomarkers.The recent “omics revolution” provides great opportunities to elucidate the biological processes linked to the treatment outcome. Here we propose a multilayer integrative omics analysis using transcriptomics and genetic and epigenetic mapping, together with detection of specific immunologic proteins, to identify biomarkers of clinical response to immunotherapy amenable to be used in liquid biopsies.Objective: to identify definite biomarkers predictive of the response to anti-PD-1, anti-PD-L1, and anti-CTLA4 therapy in patients with metastatic melanoma and advanced non–small-cell lung cancer. We structure the proposal in two parts:WP1. Signature of response to the immunotherapy by integrating transcriptomics and genetic and epigenetic mapping in tumor tissues: solid biopsy. Genome-wide transcriptomics on FAC-sorted tumor and stroma cells followed by targeted genetic and epigenetic mapping in the differentially expressed genes in responders.WP2: Identification of circulating biomarkers of response to the immunotherapy: liquid biopsy. Pre- and post-treatment blood samples from a validation cohort will be used as liquid biopsy. Genetic and epigenetic biomarkers of WP1 will be tested as circulating biomarkers. In addition, LINE-1 methylation, total Circulating Tumor Cells, CD56+, or CD8+ PD-1+ cells will be tested.This project applies multiple innovative approaches to address the urgent need of identifying biomarkers of clinical response to immunotherapy in cancer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'regeNerAtive Resilient smaRt mAnufacTuring nEtworks'.

assistant: **Innovation**

Manufacturing and logistics companies are subject to unforeseen events that disrupt the supply chain, causing production slowdowns, reduced output, and increased costs, making it difficult to meet customer demand. To mitigate these risks, manufacturers must build resilience across entire value chains. NARRATE will develop a sophisticated tool using AI, Digital Twin, and IoT technologies allowing end-to-end visibility and control over supply chain operations to monitor and predict potential disruptions, enabling supply chains to achieve improved resilience. The Intelligent Manufacturing Custodian (IMC) will leverage data from various production sources to enable proactive decision-making and act as a nerve centre for a supply-chain network, providing real-time monitoring and coordination of intelligent production processes and logistics. Integrating an IMC into a supply-chain will evolve its operations into Smart Manufacturing Network (SMN): a connected and self-orchestrated ecosystem linked end-to-end with programmable Manufacturing-as-a-Service capabilities that can withstand disruptions.A Digital Twin will provide a reliable model to represent production and operational data of an SMN to unlock deeper IMC intelligence. Collected data will train machine learning models to predict potential disruptions, such as natural disasters or delayed shipments. AI algorithms will analyse the data and provide real-time reporting and visualization on a dashboard. The IMC and Digital Twin interaction will generate powerful insights and self-adapting abilities that support an SMN to evolve under human supervision by switching services between multiple external partners to respond to risks and disruptions and improve energy efficiency, product circularity and environmental sustainabili
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Total environment fab waste gas management via networked and monitored escape disposal systems'.

assistant: **Objectives**

- To evaluate the emission of waste-gas of Al, TiN/Al, and SiO dry etching processes using CF4, CHF3, C2F6, BCl3, Cl2, SiCl4.- To evaluate waste-gas emission of SiO, PSG and SiN CVD using SiH, PH3 ,TEOS, DCS, NH3- To assess and minimise the cost of ownership of above mentioned disposal processes based on network data collection by ESCAPE-NET.The performance of a monitored network of DAS ESCAPE waste gas abatement systems will be assessed in the production line of the IC manufacturer ZMD.Four critical disposal processes have been selected to demonstrate the technical performance of the networked ESCAPE system under production conditions, together with the cost advantage of monitored networks of abatement systems over the same number of independently used ones.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Elaboration de materiaux pour la fabrication de tuyaux flexibles alimentaires ainsi que les equipements appropries' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of this project is to realise flexible riser pipe in long lengths and meeting the regulations of the food industry. Those hoses are basically designed to be used as self sustained risers, resistant to corrosion, encrustation, ageing and abrasion. These flexibles are particularly interesting when the pumping system requires the submersed pumps to be set up and risen rapidly with limited means. For some applications, particularly for drinking water pumping and for the food industry, the hoses must meet the strict regulations set up in several countries (Germany, Belgium, France, ...). Regarding to those regulations, the main objective of the research is the development of a new compound. These are the 2 basic grounds for the technical and commercial success of this product.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Unbabel: Scalable, affordable and seamless content globalization using distributed crowd-post editing' (Unbabel), addressing dissemination and exploitation.

assistant: **Impact**

Globalisation is causing a dramatic increase in the demand for translation services, but current translation solutions are unable to provide the scalability, affordability and quality required to eliminate language barriers between companies and their customers. Unbabel is developing a translation service that combines machine translation and distributed crowd post-editing as a service, powered by innovative technology and a growing community of bilinguals and professional translators. Unbabel’s goal is to integrate seamlessly into tools that companies already use to communicate with their customers, such as Zendesk, MailChimp, WordPress and Github. This approach will enable any company to rapidly and affordably scale their business internationally. Unbabel has already translated more than 8 million words and beta customers of the first two integrations have demonstrated impressive results. In phase 1 of this project, Unbabel aims to prioritise and allocate investments in building further integrations with internet tools such as Github, Salesforce, Wordpress, Gmail and Etsy. A market study will be performed to evaluate the economic viability of each of these integrations. In addition, Unbabel will study the User Experience design of a fully functional mobile application that enables translators to be part of the Unbabel community from anywhere in the world, creating a new source of income to bilinguals worldwide. In phase 2, Unbabel aims to dramatically improve the profitability of the translation process for both Unbabel and the Unbabel Translator Community while reducing the cost of translation for our customers. This project will have a tremendous positive impact on both customers, in quantitative terms, on market size and turnover, and translators, in qualitative te