RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of Next Generation Cobalt Superalloys - Understanding and Limiting Microstructure Degradation and Creep' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Ni superalloys utilised in gas turbine hot sections are mature, and their temperature capability is the limitation to improving engine efficiency and reducing CO2 emissions. The Co superalloys demonstrate higher temperature capabilities and are a potential replacement. Successful alloy development will boost the EU economy by increasing the competitiveness of Rolls-Royce (UK’s largest exporter), and invigorate multi-disciplinary research across the ERA. Other gas-turbine technologies will require research and development due to higher operating temperatures, such as ceramic coatings and mechanical design of turbomachinery.Superalloys are strengthened by fine coherent ordered γ′ particles that hinder dislocation motion through the γ matrix. The γ/γ′ interface has an associated interface width, and the importance of this width in governing microstructural evolution (coarsening) and associated loss in creep strength is debated. It has recently been shown that the interface width can be controlled with alloying additions. In this proposal, interface widths will be systematically altered across a range of Co-Ni-Al-W-Cr superalloys, measured by atom-probe tomography, and coarsening experiments performed to determine if this width is the rate-controlling mechanism during coarsening. Interpretation will be aided by development of a coarsening model. Coarsening will be related to mechanical properties by performing creep tests on samples with different microstructures, and an extensive TEM study is proposed.The supervisors, Prof. Seidman, Prof. Voorhees, and Dr. Stone, are world leaders in their respective fields at world leading Universities, Northwestern University and Cambridge University. The application discusses the development of the researcher to ensure his future succes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Neuroactive compounds in Tomatoes and their role in the development of neurodegenerative diseases via the gut-brain axis using a multi-Omics approach'.

assistant: **Objectives**

Neurodegenerative (ND) diseases are debilitating and largely untreatable conditions that affect millions worldwide, including 7+ million Europeans. Although there remains no cure, there is growing evidence of a correlation between diet, gut, and ND diseases but a deeper understanding of what happens to neuroactive compounds once digested and their role in the communication between gut and brain is still missing. In response, NeuroTOm will answer complex questions about human exposure to neuroactive compounds (using tomato as a model food), such as what happens to these chemicals during digestion and their role in the gut-brain axis and ND disease development. It will use advanced mass spectrometry-based techniques to characterise neuroprotective and neuro-disrupting compounds in tomatoes produced organically, conventionally, and processed. An in vitro batch colon model will then be applied to investigate the fate of these compounds in the gut microbiome and identify gut-microbial metabolites. A step towards more realistic conditions will be made by investigating how the presence of neuro-disrupting compounds influences the bioavailability and beneficial effects of neuroprotective compounds in the gut. Selected compounds will also be tested using an innovative in vitro 3D colon (organoid) model to determine the role of neuroprotective/disruptive compounds and their gut microbial metabolites on intestinal epithelium cells. The proposed research is highly interdisciplinary and encompasses analytical and food chemistry, holistic and multi-omics approaches, nutritional biochemistry, biotechnology, and aspects of neuroscience. The goal of NeuroTOm is to extend the knowledge of diet–gut microbiome–host (brain) interactions and will contribute towards preventing or alleviating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The role of rna polymerase transcription factor iih tfiih as a molecular switch between transcription and repair', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content Eukaryotic cells have evolved a spectrum of mechanisms to cope with DNA damage. A large number of genes encoding proteins involved in the major cellular repair pathway, nucleotide excision repair (NER), have been identified and analyzed. A protein complex, RNA polymerase II transcription factor IIH (TFIIH), has been shown to be involved directly in transcription, DNA repair, and cellcycle regulation. Thus, TFIIH likely represents a main component in the communication of signals from damaged DNA to the transcription and cell-cycle machineries. Therefore, studies of TFIIH function in these processes, and as a molecular switch between them, are crucial for our understanding of the mechanisms cells employ to avoid deleterious DNA damage leading to oncogenic transformation. By combining the power of yeast genetics with molecular techniques and biochemical analyses, I wish to focus my post doctoral training on: Reconstitution of the TFIIH complex from single (recombinant) subunits to define the functional core, and thereby shed light on the specific role(s) of each protein in the complex. And furthermore, characterization of the nucleotide excision repairosome assembly pathway and the conversion of TFIIH from a transcription factor to a repair complex. Training content (objective, benefit and expected impact) See above.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Advanced RF front-end TEchnology using MIcro machined Si/SiGe structures'.

assistant: **Concept**

The project will realize novel low-cost RF front-end subsystems for operation preferably in the license-free 24 GHz ISM band, such as high-speed data links for advanced smart card applications, and RADAR sensors for automotive and traffic control applications. It will combine advanced Silicon-Germanium heterostructure semiconductor devices with advanced passive components using Silicon micro machining and organic dielectrics. The application of micro machining techniques and organic dielectrics will allow to realize on-chip antenna structures and low-loss passive components, while maintaining the cost and manufacturing benefits of standard low-resistance Silicon substrates and established Silicon processing techniques.Objectives:Silicon/Silicon-Germanium heterostructure bipolar transistors and Silicon micro machining techniques will be combined to provide a novel monolithic integration technique capable of providing low-cost solutions for wireless communications and sensing applications in the upper microwave frequency range. Specifically, the technology aims at realizing short-range wireless data communications and RADAR sensor subsystems operating in the license-free 24 GHz ISM band. Micro machining techniques are being used to reduce microwave losses in low- to medium-resistivity Silicon substrates, and to realize on-chip antenna elements. Micro machining and passive structures using thick organic dielectrics will be used preferably as a backend process to Si/SiGe IC fabrication; their development will be guided by mass-production compatibility. Novel packaging solutions will be researched as an integral art of providing low-cost RF front-end solutions.Work description:An emerging commercial Si/SiGe HBT process with cut-off frequencies up to 80 GHz will serve as the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Development of standard test procedures for electromagnetic interference (EMI) tests and evaluations on photovoltaic components and plants'.

assistant: **Objectives**

OBJECTIVES OF THE PROJECT On the 1 st January, 1996, new laws on the 'electromagnetic compatibility of appliances (EMC)' came into force as legal basis for the electromagnetic compatibility in most countries of the European Union. There is uncertainty among representatives of the affected trades on the specifications which have to be met by components and systems (especially for PV). The objective of the 'PV-EMI-Project' is the realization of a standardized European approach towards the Electromagnetic Compatibility of Solar Photovoltaic ('PV') Systems by means of elucidating the legal situation, developing measuring concepts, doing concrete sample measurements and realizing information dissemination to standardization committees and final users (industry, SMEs, plant owners). TECHNICAL APPROACH The technical approach is to reconcile legal pretensions on EMC and safety aspects with specific technical features of PV systems and components by: - collecting a survey over EC EMC standards applicable to PV systems and plants. The technical demands resulting from the standards and regulations will be adapted to PV systems and basic requirements for measurements will be identified. - identifying and developing measuring concepts to prove, that PV systems comply with essential protection requirements, - discussing the relation between EMC measures and other safety concepts, especially by elucidating the influence of lightning and overvoltage protection measures to the EMC behaviour, - performing sample measurements to prove the applicability of the developed measuring concepts and to produce general examples as orientation. - preparing recommendations on guidelines, forms and information sheets for use of standardization committees and application by PV specialists and owners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developing and implementing a community-based intervention to create a more supportive social and physical environment for lifestyle changes to prevent diabetes in vulnerable families across Europe' (Feel4Diabetes) targeting Horizon 2020.

assistant: **Abstract**

The Feel4Diabetes project addresses “HCO5-2014: Global Alliance for Chronic Diseases: prevention and treatment of type 2 diabetes”. The aim of this project is to develop, implement and evaluate a community-based intervention aiming to create a more supportive social and physical environment to promote lifestyle and behaviour change to prevent type 2 diabetes among families from low and middle income countries and from vulnerable groups in high income countries in Europe. Methods: The PRECEDE-PROCEED Model will provide the theoretical framework for the development, implementation and evaluation of the Feel4Diabetes intervention. The framework has two phases, namely the PRECEDE and PROCEED phase. During the PRECEDE phase, the target population as well as behaviours related to type 2 diabetes and their determinants will be identified. Existing research programs and guidelines for type 2 diabetes prevention, policies, legislation, local infrastructure and human resources will also be recorded. Based on the knowledge gained from this phase, a low-cost and applicable in low-resource settings community-based intervention programme will be developed, with the active engagement of local stakeholders, providing access to the existing infrastructure and human resources wherever feasible. During the PROCEED phase, the intervention will be implemented and its process, impact, outcome, cost-effectiveness and scalability will be evaluated. The results of the intervention will be disseminated, aiming to embed it into policy and practice. Consortium: The Feel4Diabetes multidisciplinary consortium incorporates the necessary expertise on diabetes prevention, behaviours, nutrition, physical activity, policy and health economics. It consists of 10 partners from 7 universities, 1 research in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Molecular mechanisms of resistance, virulence and epidemicity in Streptococcus pneumoniae. PREVIS (Pneumococcal Resistance Epidemicity and Virulence - an international study'.

assistant: **Concept**

Human pathogens face two main kinds of evolutionary challenges. A. Survival and growth in an antibiotic rich milieu selects for genetic traits of resistance. B. Successful drug resistant strains must also be able to compete with other members of the species for colonization, spread and disease in the host. The main purpose is to examine the interplay of these two - as well as host and environmental - factors. Streptococcus pneumoniae (SP) remains among the most important causes of life-threatening community-acquired diseases. Drug resistantpneumococcal clones (DRPn) emerging from a major ecological reservoir (healthy children in Day-care centres) are widely spread in Europe threatening effective antibiotic therapy. Our multidisciplinary expertise of collaborating centres will identify bacterial genetic determinants and host factors associated with invasive disease, DRPn and spread of epidemic SP clones. The project will focus on(a) frequency and clonal types of drug resistant and drug susceptible SP causing invasive disease and found among healthy carriers, to study disease potential and transmission dynamics;(b) genetic determinants of virulence and resistance using comparative genomics and transcriptional profiling involving DNA microarrays based on sequenced genomes;(c) sequencing of S. mitis, a frequent source of genes and gene fragments resulting in SP resistance;(d) the ability of antibiotic resistance determinants to affect pathogen-host interactions and identification of host factors;(e) novel approaches to develop anti-virulence drugsf) the threshold level of antibiotic consumption in the community that selects for resistance;g) integrating data by development of a web-based data management infrastructure coupled with advanced machine learning tools for automat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SoundTrack-HF: Noninvasive prediction of acute events in patients with chronic heart failure' (SoundTrack-HF).

assistant: **Concept**

Heart failure (HF) is a chronic condition which tremendously impacts the life quality and expectancy of the patient as well as the healthcare system. The main responsible are acute episodes of decompensation, which are difficult to promptly detect because signs and symptoms occur late in the process. It was previously proved that changes in the hemodynamic parameters anticipate acute episodes by weeks, and their monitoring could be leveraged to predict and prevent the episode itself. Nevertheless, at date, this can only be performed via invasive sensors, which limit the target population to patients with severe HF. SoundTrack-HF targets this gap in the technology for HF monitoring. The goal of SoundTrack-HF is to design, implement and validate an end-to-end system for the non-invasive monitoring of the status of compensation of HF patients using heart sounds (HS).The project grounds on the use of a novel prototype enabling the self-recording of HS by the patient in a homecare setting. Cross-sectional and longitudinal data will be obtained from HF patients at their domicile. Time-related biomarkers related to the hemodynamic functionality will be extracted from the signals and validated against a gold standard (echocardiography). On one side, the patho-physiological spatio-temporal changes in the parameters will be modelled and interpreted in relation to the status of compensation of the patient. On the other side, an explainable AI-based acute episode predictor will be developed and used to extract novel knowledge about the relationship between HS and HF. At the end, signal- and AI-extracted knowledge will be integrated into a final predictor. SoundTrack-HF is a highly interdisciplinary project. Its innovation resides in the development and validation of groundbreaking
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European Programme on Prediction Of climate Variations on Seasonal and interannual Timescales', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

To quantify the predictability of the atmosphere on seasonal timescales over Europe and regions of the world where there may be European interests, and to test the skill of coupled models of the oceans, atmosphere and land surface, including data assimilation to provide initial conditions. The first objective is being pursued through a series of coordinated experiments using four European atmosphere  models. These models are being run in ensemble mode over seasonal timescales using observed sea surface  temperature and initial conditions from the ECMWF reanalysis period 1979-1994. This coordinated  experimentation was underway at the beginning of the project, and is likely to be completed by the end of the  first year. Diagnosis of results will take another year, and involves additional participants in the project.  Complex numerical coupled models and ocean data assimilation techniques are being developed by five  participants of the projects, and the ability to run hindcast experimentation will be possible by the second year  of the project.  Testing the skill of the numerical coupled model seasonal forecasts will begin in the second year of the project,  through coordinated experimentation. Special attention will be given to the period 1990 onwards, since the ocean  (especially the El Niqo region), was relatively well observed in that period.  The skill of dynamically based seasonal forecasts will be compared with that obtainable by empirical prediction  techniques. In addition the possibility of using these techniques (eg based on singular value decomposition) to  correct, a posteriori, dynamical model biases will be investigated.  Finally, close coordination between PROVOST and the monsoon project SHIVA will take place throughout the  term of the project. As well a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Experimental and clinical dissection of innate immunity against intracellular pathogens' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The innate immune system provides a fast response against invasion by pathogens and also determines the quality of the adaptive immune responses. Chlamydia, Mycobacterium and Rotavirus species are intracellular pathogens that cause a variety of severe human diseases. Because of the high incidence of these infections world wide, new or improved tools are necessary to reduce the burden that these pathogens pose on public health. We plan to investigate the role of innate immunity in resistance and pathogenesis of Chlamydia, Mycobacterium and Rotavirus infections in patients and animal models. Our long-term goal is to provide, by targeting the innate immune system, a novel vaccine and therapeutic strategy. Specifically we will examine the roles ofa) pathogen recognition by innate immune responsesb) cytokine modulation of innate responses in the outcome of infection with each of the three pathogens.We will also focus on the identification of human genes responsible for predisposition to disease. Finally, we intend to use innate immune molecules such as cytokines as adjuvants to improve vaccine strategies.