RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PatientDataChain - Blockchain approach to disrupt patient-provider medical records data exchange' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Setrio’s PatientDataChain blockchain-based technology is a game-changer for decentralizing infrastructure and building a trust layer in the healthcare value chain. This could dramatically reduce time delays, added costs, and human error that plague healthcare value chain today. PatientDataChain has significant power to disrupt healthcare and put data in the hands of patients. PatientDataChain uses Smart Contracts to map patient-provider relationships (here the contract shows a list of references detailing the relationships between nodes on the blockchain). It also puts patient-provider relationships in the hands of the patient, giving them the ability to accept, reject, or modify relationships with healthcare providers such as hospitals, insurers, and clinics. PatientDataChain gives patients and doctors an immutable log of healthcare records. It takes a different approach to incentivation for patients by giving access to anonymized healthcare data in exchange for sustaining the network. It breaks down the existing barriers that currently obstacle communication on patients’ journey along the health value chain. Thus, for the care pathway, the workflows and patient processes are streamlined. The solution improves care adherence, operational efficiency and patient experience thus leading to better health outcomes and lower costs. PatientDataChain will lead to (i) an enhanced exchange of information among health players and stimulation of new synergies, (ii) a reduction of costs and simplification of procedures for demonstrating regulatory compliance, (iii) an increased awareness on patients’ data also among patients themselves together with a better understanding of their health journey, and (iv) generation of big data on the patients’ journey along the health value chain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Photoinduced Chemistry: Development and Application of Computational Methods for New Understanding' under Seventh Framework.

assistant: **Concept**

The interaction of light and matter gives rise to a multitude of important and fascinating phenomena.Computational studies of excited states are vital to further our basic understanding of these processes, anddesign and optimise new processes for particular applications. However, the computational chemistry ofexcited states gives rise to many challenging features, including differential static and dynamic correlationeffects, which can often be difficult to separate. Furthermore, regions of non-adiabatic coupling betweenvarious potential energy surfaces are ubiquitous in photochemistry. Such regions where the Born-Oppenheimer approximation breaks down are among the most difficult to treat.The computational chemist must use a wide variety of methods to study photochemistry. However,one important ‘tool’ in the computational arsenal is currently missing for general photochemical problems:namely the ability to undertake systematically converging computations over all of the relevant regions ofthe various (multi-state) potential energy surfaces. The Monte-Carlo Configuration Interaction (MC-CI)method is ideal for this purpose, and has many desirable features, including automatic inclusion of strongstatic correlation effects, and a balanced treatment of all states. Development of MC-CI methods, includinggradients and non-adiabatic couplings is proposed. This will give rise to the unprecedented ability tobenchmark a large variety of photochemical problems, across the entire potential energy surfaces, withsystematic accuracy. The method will be further extended by coupling within molecular mechanics in aquantum mechanics / molecular mechanics (QM/MM) framework to study general excited state / open-shellproblems in complex environments.The work will lead onto the applications res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Ecological and human health risk assessments of antibiotics and anti-cancer drugs found in the environment.'.

assistant: **Concept**

A consortium of world-class scientists from both academia and industry has been assembled to assess the risks to wild animals and humans posed by environmental exposure to pharmaceuticals.  Their expertise will be supplemented by an advisory group consisting of representatives of all stakeholders. This project will concentrate on two classes of human pharmaceuticals, namely antibiotics and anti-cancer drugs, because there are good reasons for thinking that these could be of particular concern.  In order to conduct sound risk assessments, including providing estimates of uncertainty, it will be necessary to obtain accurate data on both exposure concentrations and effects levels. Hence, new data on both environmental concentrations and effects on aquatic organisms will be produced during the project. The comparative sensitivities of embryos and adults will be determined, and used to reduce uncertainty in the risk assessments. The stable transformation products of the selected pharmaceuticals will also be investigated. All stakeholders and beneficiaries will be represented in the project, so that results are rapidly and reliably transferred to all interested parties. A prototype web-based classification system will be developed during the project with the intention of enabling all EU citizens to make their own informed decisions about the risk posed by human pharmaceuticals to their health and to the health of the environment. The results will able EU regulators and policy makers to make better informed decisions on the issue of pharmaceuticals in the environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Demonstration of a new combined mechanical / thermal waste incineration process' to be submitted under Fifth Framework.

assistant: **Abstract**

European waste policy focuses on the following priorities: Prevention, Recycling and Disposal. According to the legislation producers and owners of waste are obliged to recycle waste or use it thermally (energetically). Against this background there is a great market demand for new and innovative solutions in order to transform the chemical bounded energy (CBE) of waste into valuable products such, for example, as electricity. The process proposed here has been developed to be applied in small and mid size communities and to produce secondary fuel at high quality standards which gives the possibilities to avoid conventional waste incineration plants. The objective of the proposed demonstration project here is to prepare and implement a demonstration plant, which enable small and mid size communities to solve their water problems economical and ecological. The main objective of the process is to produce secondary fuel with high quality standard.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Gated INTERfaces for FAST information processing' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

INTERFAST will develop a novel technological platform for the voltage control of interfacial magnetism. The key idea is to manipulate, via a gate, the hybrid states at the interface between a magnetic material and an organic layer, in a way to affect the effective spin-orbit coupling at such interface. This will allow us to actively control the interfacial magnetism of a wide range of magnetic and supporting compounds, thus providing a universal platform, which is not specific of the rare magnets having massive voltage-control magneto-crystalline anisotropy coefficients. INTERFAST will demonstrate the applicability of this technology to a range of key spintronic functions, encompassing voltage control of magnetisation reversal at fJ/bit energy cost, drastic reduction of the spin-orbit-torque switching currents, and ultrafast THz information processing in all-metallic spintronic devices aided by gateable hybridisation unit.


**Keywords:** Beyond CMOS, interface spintronics, fast information processing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cardiac regeneration by mRNA-triggered proliferation of cardiomyocytes' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Heart failure (HF) is a major health problem worldwide because of the high number of patients and the related costs. Current treatments are not consistently efficacious and fail to address the major underlying cause of HF: the massive loss of cardiomyocytes in damaged regions. REGeRNA has been designed to address this issue by leveraging advances in synthetic mRNAs and their lipid nanoparticle (LNP)-based carriers to generate a construct able to reactivate mechanisms mediating cardiomyocyte proliferation in development but which are shut-down shortly after birth. REGeRNA is organised in 6 work packages that follow a roadmap towards endogenous heart repair. The program starts tailoring various human assays and in vitro models such that they can reliably document cardiomyocyte proliferation. These will then be used for screening pathways thought to be involved in cardiomyocyte division, among which Hippo is our primary candidate. mRNA(s) encoding the relevant proteins will be subsequently synthesised and engineered such that their expression is restricted to cardiomyocytes and no stromal cell expansion occurs. An LNP formulation will then be developed for incorporation of the synthesized mRNA(s) and optimized for cardiomyocyte-specific delivery. Subsequently, we will test the mRNA+LNP construct in our human model systems and in mouse models of myocardial ischaemia/reperfusion including transgenic strains that allow unequivocal assessment of cardiomyocyte division in vivo. We will then construct a GMP production line for the mRNA-LNP encapsulation technology to generate pilot batches for pig studies entailing catheter-based endomyocardial injection of the construct in a similar myocardial ischaemia/reperfusion model. The final work package will be responsible for the manag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Four dimensional x-ray crystallography of penicillin and biosynthetic enzymes: towards new antibiotics'.

assistant: **Concept**

Penicillin and cephalosporin antibiotics are amongst the most important therapeutic agents in use (est. size of antibiotic market is 15 billion ECU per year). Some penicillins are produced by direct fermentation, but all cephalosporin and most penicillin antibiotics are produced by complex and expensive synthetic modifications of fermented products. The objective of this project is to develop our understanding of the structures and mechanism of two enzymes which catalyse key steps in penicillin and cephalosporin biosynthesis to allow engineering of their specificity. Subsequently, the modified enzymes will be introduced into micro-organisms so that penicillins and cephalosporins of choice may be directly fermented without the need for synthetic modification, with concomitant reductions in production costs and toxic by-products. The key steps in penicillin and cephalosporin biosynthesis are catalysed by the ferrous dependent oxygenases, isopenicillin N synthase (IPNS) and deacetoxycephalosporin C synthase (DAOCS), respectively. The genes for both of these enzymes have been identified, cloned and over expressed. The crystal structure of an inactive form of IPNS has been solved by us and the structure determination of DAOCS is in progress. In order to identify the key residues for catalysis and substrate specificity structural data on enzyme substrate/intermediate/product complexes is required. This will involve the development of new techniques for fast protein purification, anaerobic co-crystallization of these highly labile and oxygen sensitive enzymes and for the triggering and monitoring of reactions in the crystalline state. The latter will include a combination of time-resolved diffraction techniques and other biophysical methods (e.g. time resolved single crystal X
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Molecular, Environmental and Nutritional Evaluation of Bambara Groundnut (Vigna subterranea L.Verdc.) for Food Production in Semi-Arid Africa and India', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Bambara groundnut can contribute to food security of some of the worlds poorest people. Traditional landraces have good nutritional properties, drought tolerance and can yield protein-rich pods where other crops may fail. Recent EU-funded research has deve loped the first hybrids of bambara groundnut landraces. This proposal links partners in Africa, Europe and India in a project that combines molecular, environmental and nutritional studies and end-users of bambara groundnut. By dissecting the underlying ge netics of the crop and testing its performance across a range of environments, the project will establish criteria and resources required for systematic, regional breeding and improvement programmes that minimise duplication of effort. Within 4 years colla borators will produce the first varieties of the crop, assess products for a range of uses and identify cultivars and management practices to optimise performance in specific environments. Two genetic linkage maps of bambara groundnut will be made - a `wid e' cross (cultivated x wild relative) and a `narrow' cross (cultivated x cultivated), using AFLP, SSR and DArT markers. Collaborators will identify genes and QTL's for drought, heat and cold tolerance and photoperiodic control of pod filling and will link genetic and biochemical composition of seeds from genotypes to quantify nutritional composition, nutritive value and processing potential. The development of microarray-based accessions for landraces, microsatellite markers and genetic maps for bambara gro undnut, will be coupled with agronomic and physiological assessment, through multi-environment QTL analysis and the testing of common landraces across locations. Key traits will be dissected and markers developed. The genetics underlying nutritional and pr oc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Perfectly interfaced nanomaterials for next generation oxide electronics' (NOVOX), addressing dissemination and exploitation.

assistant: **Impact**

Oxide thin film heterostructures hold the key to a wide range of novel, and energy efficient devices of many different sorts. In the last few years, there has been a plethora of very exciting reports in the top journals on the basic science of single layer oxide films or heterostructure devices. However, the holy grail of applications is still just an event on the horizon. An innovative and emerging materials science led approach is now required to understand the factors at play limiting these highly promising materials, thus opening the door to realising their functional potential. As time progresses the interfaces are playing an ever stronger role in the functionality and multifunctionality. New kinds of interfaces, new ways to control them, and state-of-the art probing of them are all needed to understand how to control and tune them. This proposal strikes at the heart of all these issues and aims to realise the true power of oxide electronics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'CO-benefits and Risks of Enhanced Silicate weathering in agriculture' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

CO2 is a potent greenhouse gas and the primary cause of global climate change (GCC). Among others, GCC induces extreme weather events, producing an extensive impact on natural and agricultural systems. Climate change mitigation requires an urgent decrease in CO2 emissions together with active CO2 removal from the atmosphere. Enhanced silicate weathering (ESW) is a promising negative emission technology for CO2 removal but requires further research. ESW accelerates the natural process of weathering-based silicate to carbonate transformation, by increasing the surface area of silicate rocks. During the weathering process, CO2 is sequestered. Agricultural fields are ideal for ESW, due to ease of access, equipment availability and infrastructural capacity. In an agricultural setting, this application can be further beneficial as the silicate rocks like basalt contains elements that promote plant growth and soil health. In addition, GCC endangers crop production by inducing drought and salinity. Approximately 75% of the cropland is subjected to drought-related yield loss while salinity affects around 50-80% of global croplands. Moreover, impacts of drought and salinity are anticipated to rise in the future due to GCC. The negative effects of drought and salinity can be countered by ESW through (i) the preservation of crop yield and quality by the silicon (Si) mediated drought and salt stress tolerance in plants and (ii) the protection of soil microbiota by the stabilization of soil chemistry. Although ESW could contribute to climate change adaptation in agriculture, these promising co-benefits were never assessed, and further research is needed to evaluate this potential in different agricultural settings. In project CORES, I aim to examine the potential of ESW, with silicat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'VIrtual healTh And weLlbeing Living Lab InftraStructurE' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Researchers in the Health and Wellbeing domain need 1) convenient access to research infrastructures, 2) direct engagement of people in order to validate hypotheses, co-design solutions and services, evaluate their feasibility and effectiveness and participate in the translation and mobilization of outcomes and 3) experience from multidisciplinary domains (e.g. healthcare management, assistive technologies, data science) to deal with the complexity of health and wellbeing research. Over the last few years, Living Labs have emerged as resilient research and innovation infrastructures and have proved to be key to the integration of research and innovation processes in real life settings, focusing primarily on people and their engagement in research procedures. VITALISE opens up Living Lab Infrastructures as a means to facilitate and promote research activities in the Health and Wellbeing domain in Europe and beyond by enabling in-person Transnational Access to 17 Living Lab research infrastructures and by supporting remote digital access to datasets (Virtual Access) of rehabilitation, transitional care and everyday life activities through harmonized processes and common tools. VITALISE will design and develop ICT tools for shared access of similar devices and applications used across Living Labs, as well as for collecting, storing and sharing datasets. Lastly, VITALISE will invest in the development of Training methods towards the wider understanding and valorisation of Living Lab methodologies in the research community.


**Keywords:** health infrastructures, living labs, co-creation, rehabilitation, transisions in care, living environments