RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Black Hole Interactions and Neutron star Collisions Across the universe'.

assistant: **Objectives**

Recent years witnessed a blossoming of multi-messenger astrophysics, in which gravitational waves (GWs), neutrinos, and photons provide complementary views of the universe and its most enigmatic objects, such as black holes (BHs) and neutron stars (NSs).  The staggering dataset collected for the compact binary merger GW170817 -- including fundamental contribution by the PI -- showed the tremendous discovery potential of this field, which will unfold in the years ahead of us. The global network of interferometers will progressively sharpen its view of the gravitational wave sky and could soon allow us to see a new kind of light, arising from the encounter of a NS with a stellar mass BH. At the same time, wide-field gamma-ray instruments will continue to pinpoint these violent collisions in distant galaxies, and sensitive all-sky surveys might soon reveal the collision aftermath without the aid of gravitational or gamma-ray alerts.  On the verge of a transformational era in the study of transients, I propose a cutting-edge investigation of compact binary mergers harnessing the unprecedented wealth of multi-messenger and multi-wavelength data. By combining a vigorous observational program with theoretical research at the forefront, this project will allow my team to fully exploit the discovery potential of a vastly uncharted territory and tackle the following emerging questions. Do all compact binary mergers launch relativistic jets?  Are they the primary cosmic source of heavy metals?  What are the properties of cold ultra-dense matter, and how do they affect the observed light? Can we use these mergers for precision cosmology? Stemming from the PIs pioneering results, BHianca is uniquely positioned to timely address these central questions, and lead to seminal results in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The DIffuse Galaxy Expansion SignaTures In Various Observables project: understanding the emergence of diffuse, low surface brightness galaxies and the link to their dark matter haloes', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

I propose to carry out the ‘DIffuse Galaxy Expansion SignaTures In Various Observables’ (DIGESTIVO) project, a joint theoretical and observational effort alongside observers at the Instituto de Astrofisica de Canarias (IAC), to study the evolution and formation of Low Surface Brightness galaxies (LSBs), including the recently discovered Ultra-Diffuse Galaxies (UDGs). LSBs are extremely dark matter dominated, faint objects hardly distinguishable from the night sky. In the last decade it has became clear that large numbers of LSB galaxies exist, opening a new window on galaxy evolution and formation. How do such diffuse galaxies form and evolve? How are they linked to their dark matter haloes, and how do they fit within the current cosmological model of galaxy formation?  To answer these questions, I will make use of state-of-the-art, sophisticated hydrodynamical numerical simulations of galaxies, my field of expertise, combined with new observational data of LSBs/UDGs, which will be attained by observers at the host institution thanks to new techniques that will push the frontier of LSB imaging with optical telescopes. The goal is to study and understand the properties of diffuse galaxies: we will test our current theory according to which LSBs/UDGs arise from gas outflow episodes driven by supernovae feedback, which give rise to an expanded distribution of dark matter and stars. Searching for signatures of dark matter and stellar expansion in LSB galaxies is indeed a central theme of the proposed research, as we try to  understand how LSBs  arise in a galaxy formation context, which is currently an open issue.This is the first time that a joint theoretical and observational effort on LSBs is developed: ultimately, this will offer invaluable insights on the formation of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Bioeconomic modelling of the fisheries of the English channel.', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The English Channel/La Manche contains a number of multi-species multi-gear fisheries. These fisheries are exploited by UK, French and Belgian fishers. The objective of this project is to develop a bioeconomic model of the fishery than encapsulates the key economic, biological and technical interactions in the fishery. This model, when finalised, may be use to examine the potential effects of fisheries management policies on both the financial and economic status of the fishers as well as the biological status of the resource.Biological componentThe key species in the Channel were classified into three main categories (Table 1). The first category are species for which data are considered adequate to develop age structured dynamic models. The second group of species are those where the data is adequate for the development of dynamic models, but these are likely to be simpler models (e.g. surplus yield models). The third category includes those species where there is insufficient data to develop dynamic models, but are sufficiently important (economically) to keep in the model as separate species. All other species will be aggregated into general categories (e.g. other crustaceans etc.).TABLE 1. CLASSIFICATION OF SPECIES FOR WHICH DATA IS AVAILABLEN° Dynamic Modelling ICES assessed species Modelling possible(Data rich) Simple stochastic model (ad-hoc) cod edible conger eel  hake crab crawfish mackerel pollack john dory  herring scallops lobster  monkfish spider lemon  plaice crab sole sole turbot ling whiting brill megrim  bass pout cuttlefish  dab  spurdog gurnard  red mullet queens  black bream  skates and rays squidTo date, only limited analyses have been undertaken. Initial use of length and age based assessment techniques on UK data for turbot, brill and black bream
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Reinforcement of the centre for computational solutions in the life sciences' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The Centre for Computational Solutions in the Life Sciences is a multidisciplinary collaborative research venture situated at the Ruder Boskovic Institute in Zagreb, Croatia. The activities of the Centre range from bioinformatics of entire genomes to quantum-mechanical treatment of small model systems and include efforts focused on docking, proteomics, and mechanistic biochemistry.The primary objective of this project is to improve and reinforce the research capacities of the Centre. It is from this position of enhanced strength that we intend to work towards our goal of increasing the uptake of computational approaches to the life sciences in the Western Balkan region. We propose to realize our objectives on several different, yet equally important, fronts. Firstly, through the implementation of a novel dynamic recruitment initiative, we intend to complement our existing human resources and combat an important cause of brain drain" in Croatia.By improving our material infrastructure, we intend to strengthen our potential to perform high quality research and to increase regional access to hi-tech facilities. We intend to coordinate an extensive programme of exchange and training visits with key partner centres in the Member States and the other Western Balkan Countries. These visits will be strategically timed to maximize the regional impact of our local educational measures. Wider reaching dissemination activities will include the organization of two regional workshops.The meetings are conceived with the particular emphasis of increasing awareness of, and access to, computational approaches to the life sciences for young researchers from the Western Balkan Countries. Finally, in addition to the aforementioned activities, by carrying out research directed at key themati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The next generation of railway crossing asset management technology' to be submitted under Horizon Europe.

assistant: **Abstract**

Railway crossings degrade significantly faster than plain line track, with lifespans commonly lasting less than 5 years despite their design lives typically being 15 years. This results in Billions of Euros being spent on unplanned corrective maintenance, crossing renewals and delay-minutes, which would not occur if they could be better managed to reach their design lives.XCROSS will develop a suite of integrated disruptive technologies which combine to provide a technological process for the monitoring, inspection, and maintenance intervention of crossing surface profiles. To achieve the objectives, new crossing inspection techniques will be developed using 3D laser scanning technology and computer vision to allow for fast, repeatable and high accuracy crossing measurement. These 3D scans will then be used to create digital twins (DT) of the crossing, embedded with advanced wheel-rail interaction calculation algorithms. Considering these wheel forces and also on-site practical maintenance constraints, the digital twin will use optimisation strategies to calculate the optimal geometry profile achievable via on-site welding and grinding techniques in terms of lifecycle cost. Then, to enable practical implementation of the calculated optimum crossing profile geometries, Augmented Reality (AR) and 3D printing techniques will be developed to provide visualisation guides for on-site welding and grinding. These technologies will allow the maintenance engineers to see their welding and grinding progress ‘live’, and thus be an enabler for a step-change in the quality control of crossing interventions.  Lastly, an early warning system will also be developed to act as the initial trigger for the deployment of the 3D scanning, AR and 3D printing. It is vital for detecting the earl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Active Region Classification and Flare Forecasting' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The Sun is an enigmatic star that produces the most powerful explosive events in our solar system - solar flares and coronal mass ejections. Studying these phenomena can provide a unique opportunity to develop a deeper understanding of fundamental processes on the Sun, and critically, to better forecast space weather. The Active Region Classification and Flare Forecasting (ARCAFF) project will develop a beyond state-of-the-art flare forecasting system utilising end-to-end deep learning (DL) models to significantly improve upon traditional flare forecasting capabilities. ARCAFF will increase the accuracy and timeliness of current operational flare forecast products and create new time series flare forecasts. Furthermore, ARCAFF forecasts will include forecast uncertainties, another major improvement over current systems.The large amount of available space-based solar observations are an ideal candidate for this type of analysis, given DL effectiveness in modelling complex relationships. DL has already been successfully developed and deployed in weather forecasting, financial services, and health care domains, but has not been fully exploited in the solar physics domain. Solar flare forecasts from ARCAFF will be benchmarked against current systems using international community standards, and will demonstrate ARCAFF’s superior forecasting capabilities. The datasets, codes and DNNS developed for ARCAFF will be made openly available to support further research efforts and encourage their re-use.ARCAFF is relevant to the work program as it will exploit currently available data space weather data to train DL models to improve forecast accuracy. DL itself is an innovation enabling technology and analysis of the DL models will improve scientific understanding of solar flares. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Decoupled Insulator-Supported Molecules'.

assistant: **Objectives**

The DECiMOL (DECoupling Insulator-supported MOLecules) project exploits complementary real- and reciprocal space spectromicroscopy techniques to develop key insights into the correlations which exist between electronic structure, interaction forces, and geometry of molecules adsorbed on thin insulating layers on silicon. This understanding is mandatory in areas such as molecule-based information processing or optoelectronic devices. DECiMOL will specifically aim at investigating the transition in binding situation of the deposited molecules depending on the insulator thickness as well as the molecular functionalisation by inspecting molecular properties and explore the capability to locally change the geometric or electronic state of the adsorbed molecules. Most importantly, DECiMOL will study the efficacy of decoupling molecules from semiconductor, rather than metal surfaces, via a thin insulating films by using a combination of three experimental techniques – namely scanning tunnelling microscopy (STM), dynamic force microscopy (DFM, also known as non-contact atomic force microscopy), and photoemission spectroscopy (PES). The experimental approach will be supplemented by density functional theory (DFT) calculations. Within DECiMOL, the researcher will be trained in using PES and DFT methods, which form an important complimentary approach to his previous STM and DFM based work.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unique approach to improving neurological function after stroke with SIN020' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The aim of this project is to develop a business plan to guide clinical development and commercialisation of SIN020; a glutamate receptor 5 (mGluR5) negative allosteric modulator (NAM) to promote recovery of the injured stroke brain.  Every year, 1 million people in Europe have a stroke and the healthcare and non-healthcare cost is estimated at EUR 45 billion. The only treatment option available for restoring neurological function in stroke patients is rehabilitation, which has limited effect. Since there is a 34% anticipated rise in the total number of stroke events between 2015 and 2035, there is a pressing need for a pharmacological intervention to help restore function after stroke.  Sinntaxis is developing SIN020, a repurposed investigational drug that has previously been in clinical development for another indication and can therefore enter straight in to a Phase II clinical trial. In animal models, mGluR5 NAM has been shown to help reverse lost functions in animal models of stroke and we aim to translate this exciting preclinical data to clinically validated results.  The current proposed Phase 1 project will facilitate in the development process and help define clinical and business strategies. SME Instrument funding will allow SIN020 to take a substantial step along the path of commercialisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Fpsac' (FPSAC) under Fifth Framework.

assistant: **Objectives**

Algebraic Combinatorics is a young branch in Combinatorics that undertook an explosive development over the past 10-15 years. Its attraction comes from its significance in and interaction with a variety of different subjects, many of which are major research directions in mathematics, computer sciences or physics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanism and function of gasdermin-induced inflammatory cell death' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Pyroptosis is a lytic pro-inflammatory type of programmed cell death that is induced by inflammatory caspases, a family of proteases that control the innate immune response to infection, injury or noxious substances. Inflammatory caspases are activated within so-called inflammasomes, cytosolic signalling platforms that are assembled by pattern recognition receptors upon the detection of pathogen- or host-derived danger signals. Pyroptosis is essential for antimicrobial host defense, but also promotes the concomitant release of inflammatory danger signals and leaderless cytokines that is detrimental during chronic inflammatory disease.Recently it was found that pyroptosis is caused by the cleavage of a single caspase substrate called gasdermin-D. This cleavage generates a cytotoxic N-terminal fragment of gasdermin-D that targets the plasma membrane, where it forms large permeability pores and thus causes pyroptotic cell death. Gasdermin-D is only one member of the larger gasdermin protein family, an emerging group of cell death effectors that share its pore-forming cytotoxic activity and that appear to be major regulators of inflammatory necrotic cell death.The main goal of this proposal is to comprehensively characterize the function of gasdermins in anti-microbial host defense, to investigate the consequences of gasdermin-D pore formation to the host cell and to elucidate the pathways that regulate gasdermin activation. My objectives are:1) to define the role of gasdermin-D in inflammasome-dependent anti-bacterial host defense2) to study the role of membrane repair in restricting gasdermin-D-induced membrane3) to characterize the function and regulation of other gasdermin family members during infectionBy characterizing the mechanism and function of gasdermin-induced c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Real world Outcomes across the AD spectrum for better care: Multimodal data Access Platform - Sofia ref.: 116020' (ROADMAP).

assistant: **Concept**

The aim of ROADMAP is to provide the foundation for a Europe-wide real world evidence (RWE) platform in AD by piloting multi-modal data integration tools and engaging with all key stakeholder groups for consensual definition of patient outcomes, tools and methods that are actionable and relevant. ROADMAP will leverage best practice and exploit synergies with other projects and initiatives at the national and European levels in pursue of scalable and transferable solutions for dataset characterisation, outcome classification, data standards, data sourcing, software application and guidelines on the handling and interpretation of RWE data. In parallel, the project will deepen understanding of the ethical, legal and social implications (ELSI) and health economics (HE) impact of a RWE approach for a meaningful contribution to the Big Data for Better Outcomes programme in IMI2.The ROADMAP programme will consist of 8 integrated work packages by which the Consortium will work to (1) identify relevant AD outcomes and progression markers; (2) identify and pool AD-related RWE across data sources; (3) develop and validate disease progression models combining diverse datasets and strategies; (4) develop risk/value-based costing and health economics models for HTA/regulators, service providers, industry and carers; (5) establish stakeholder-based guidelines for RWE; (6) develop a communication strategy focussing on the needs of patients and professionals; (7) develop an ELSI framework for the development and application of RWE in AD.The ROADMAP consortium brings together outstanding expertise, experience and traction in the field, including many of Europe’s top institutions, authorities, companies, experts in AD, biomedical informatics and analysis of epidemiologic and routinely col