RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced Photonic Integrated Circuits Pilot Line for Europe' (PIXEurope).

assistant: **Innovation**

PIXEurope will establish a globally unique Open Access Pilot Line, addressing key technological and production challenges associated with Photonic Integrated Circuits (PICs). PIXEurope is a distributed Pilot Line, built on a collaboration between world-class research organisations using state-of-the-art equipment to develop breakthrough technologies and processes across the complete PIC supply chain. This includes improved monolithic chip fabrication and novel materials integration processes, advanced wafer-level packaging processes, and high-throughput test and reliability analysis procedures. These breakthroughs will also enable the integration of PICs with EICs to produce advanced semiconductor systems. PIXEurope’s concept is to create a uniquely unified research, training and commercialisation platform, providing well-coordinated services to develop and de-risk advanced PIC technologies, giving Europe unprecedented control, sovereignty and a competitive advantage in this critical technology. PIXEurope will work with European manufacturers to transfer breakthrough technologies and processes to industry, creating a unique research and industrial ecosystem to increase PIC production capacity. PIXEurope will also support research organisations to bridge the gap between lab and fab, accelerating research commercialisation, and will train a high-skills workforce, ensuring companies can access the expertise they need to grow their businesses. When operating, PIXEurope will offer an unparalleled range of MPW runs, from chip to package and test, as well as specialised services.  PIXEurope will establish in-depth online and hands-on training courses on advanced PIC manufacturing, targeting 1000 attendees annually. PIXEurope will foster a vibrant European PIC community, accele
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bump and Hole approach to elucidate function of individual bromodomains of BET proteins' (Bump-BET) under Horizon 2020.

assistant: **Objectives**

Small molecules can be used to probe for biological function of individual proteins. Achieving high selectivity with small molecules against structurally similar paralogues is a challenging task that makes it difficult to characterize function of individual member in the same protein family or individual domain in protein containing multiple target domains. The Bromo and Extra-Terminal (BET) proteins play important roles in transcriptional regulation by controlling networks of genes involved in cellular proliferation and cell cycle regulation. Key to the functions of BET proteins is a pair of highly homologous bromodomains (BD) in tandem, which bind and recognize histone acetylation on its tail. Elucidation of the process controlled by BET proteins would benefit greatly from chemical probes that perturb individual BD with high selectivity. Development of small molecules, including clinical candidate drug I-BET, builds a foundation for us to utilize this chemical probe approach, however lack of selectivity of I-BET against individual BD renders it inapplicable to serve as a chemical probe for individual protein or domain. Recently, we had demonstrated the feasibility of a “bump-and-hole” approach to engineer BD of BET proteins and I-BET molecule to achieve high selectivity. Here we propose to enhance the selectivity of BD and I-BET derivative pair to apply this technology and to probe for the function of individual BD in a cell-based model. Interaction between modified I-BET and selected BD variant, which retain its histone binding functionality, will be further optimized  to achieve >100 fold selectivity against all wildtype BD. After that, a cell-based model will be built to substitute endogenous BET protein with exogenous BET containing BD variant. The ultimate goal i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular characterization of cartilage development in the cephalopod mollusk Sepia officinalis' (SEPIACARTILAGE) under Seventh Framework.

assistant: **Objectives**

The presence of cellular cartilage-like tissues outside the chordate lineage is either indicative of a common origin of cartilage as a metazoan tissue type (homology), or alternatively highlights developmental and/or structural constraints in constructing an internal cellular support tissue or endoskeleton (convergence). If a genetic program for specifying chondrocytes (cartilage cells) arose only once during metazoan evolution, there should exist a molecular fingerprint that is common amongst all lineages, despite their long independent evolutionary history. The alternate hypothesis is that cartilages found within invertebrate groups are unrelated, and thus a common molecular fingerprint would not be expected. The current study is aimed at distinguishing between these two alternatives through molecular characterization of the regulation and specification of chondrocytes in the cephalopod mollusk, Sepia officinalis. The specific objectives of this study include: 1) analysis of candidate genes involved in vertebrate chondrogenesis in the context of Sepia development. 2) identification of novel genes involved in cephalopod chondrogenesis with particular focus on transcription factors. 3) functional analysis of identified genes of interest through the use of RNA interference during Sepia development. 4) characterization of the role of any novel cephalopod genes in vertebrate chondrogenesis using the zebrafish, Danio rerio.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Modeling Assays Platform ""MAP"" for hazard ranking of engineered nanoparticles (ENPs)""' (ENPs).

assistant: **Innovation**

MOD-ENP-TOX project is a multidisciplinary project aiming to accomplish the following objectives: (i) to develop a novel and rational “Modelling Assay Platform (MAP)” which can be used as a « Risk Indicator » tool to predict the toxicity of metal-based NPs (MeNPs), and (ii) to demonstrate the feasibility of a MAP prototype – on a shortlist of MeNPs - which can be further developed to screen the toxicity of a large number ENPs. Based on the concept of Integrating Testing Strategies (ITS), the proposed generic MAP combines two main and complimentary paradigms: (1) a novel Computational Modeling Package (CMP) based on structural, mechanistic, as well as kinetic modeling tools and (2) an innovative screening (IS) strategy that allows performing multiplexed streamlined assays for calibration, refinement and validation of the computed models.First a series of classification algorithms will be applied to identify MeNPs with similar toxicity patterns, then computational modelling tools will be developed to establish a more rational relationship between MeNPs descriptors and their toxicity in a dynamic and quantitative way. An in-vitro/in-vivo IS paradigm will be developed as a scalable assessment tool to calibrate and validate the predictive power of the CMP using subsets of the training set or independent set of MeNPs (validation set) respectively.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Macro Market Power and Distribution'.

assistant: **Objectives**

Market power is about the distribution of economic surplus between firms, customers and workers. In this proposal, I use modern heterogeneous agents macro tools that incorporate heterogeneity in firm productivity, in preferences, and in market structure. I investigate the macroeconomic mechanisms that link market power and distributional characteristics and formulate welfare-improving policies that lead to efficiency gains and re-distribution.I propose a unifying framework of market power and distribution in general equilibrium, and use unique data to address the following 3 questions:1. How does firm size determine monopsony power? Large firms have lower markups yet higher markdowns. This is a key determinant behind the lower labor share in superstar firms, but we have no mechanism that explains why. I propose to use the unifying framework and Belgian VAT transaction data combined with matched employer-employee data to quantify the economic mechanism by which markdowns vary in the firm size distribution.2. How do financial frictions influence market power? Low productivity firms tend to face tighter financial constraints, leading to higher dispersion in the distribution of capital and technology. This in turn increases market power. I have access to data from a private bank (Caixabank) on a representative sample of firms' payroll, accounts, as well as credit. Within the unifying framework I aim to quantify the impact of financial frictions on the distribution of market power.3. How does labor-saving technological change affect the distribution of the labor share and market power?  Technology adoption is driven by the firm's attempt to increase profitability. Incorporating general equilibrium effects and market power, I propose to analyze the substitution patterns withi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Transactional investigations of learning in view of sustainability transitions' (LESTRA) under Horizon 2020.

assistant: **Objectives**

This project's key question is how can learning fruitfully contribute to Sustainability Transitions (ST). Its objectives are 1) to develop a new analytical and conceptual framework for investigating the connections between learning processes, the transformation of habits and customs, and (potential) STs; 2) to identify the key conditions for learning to contribute to STs; and 3) to develop a roadmap for future research in diverse settings and contexts. Achieving a breakthrough requires us to successfully connect the process and outcomes of micro learning processes to the emergence of macro societal transitions.Transactional pragmatism provides valuable inspiration to investigate the learning that takes shape in response to sustainability problems that are increasingly disturbing our habitual way of acting. It will be used to develop a novel analytical and conceptual framework by building on earlier work in environmental and sustainability education research, didactics and sustainability transition studies (WP1). The newly developed analytical toolbox will be applied to empirical data collected in three case studies: a sustainable food system in Ghent, sustainable mobility in Wetteren and a sustainable way of handling plastics in Flanders (WP2). The analyses focus on identifying key patterns of how learning through engagement with sustainability problems results in the consolidation, enrichment or (trans)formation of habits and customs (WP3), assessing and categorising the outcomes of learning episodes in terms of their potential to contribute to STs (WP4), and analysing (changes in) the socio-technical systems in the three cases in order to identify and describe potential STs in-the-making (WP5). Synthesis should result in succesfully tracing the connections between the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Wageningen nmr centre' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Description:Access to a number of different NMR spectrometers, covering a wide range of possibilities for analytical and (bio)physical research and applications in biology, agriculture, food technology, biophysics and biotechnology. Instruments available are:- 0.2-0.75 T variable field (portable) NMR spectrometer for relaxometry, diffusometry, magnetizatioj transfer and flow studies in intact plants, products (i.e.fruits, seeds, bulbs) and porous (bio)systems- 0.25-0.75 T NMR imager, based on an electromagnet with a 10 cm air gap, for anatomical and functional imaging of porous materials, (bio)reactors, plants, and other living organisms- 3 T NMR imager with a 50 cm vertical bore magnet for anatomical, functional and spectroscopic imaging of porous materials, (bio)reactors, plants, and other living organisms under well-controlled environmental conditions in a mini-phytotron (available mid 2002)- 7 T wide bore NMR spectrometer for in vivo spectroscopy, metabolic studies of living organisms, solid state NMR, and magic-angle-spinning NMR- 9.4 T wide bore NMR spectrometer for analytical NMR, high-resolution micro-imaging, multi-dimensional NMR spectroscopy for molecular structure elucidation, and solid state magic-angle-spinning NMR- 9.4 T narrow bore NMR spectrometer for analytical and fluorine NMR, and equipped with an LC accessory and MS storage unit.- 11.7 T high-resolution NMR spectrometer for high resolution molecular structure elucidation.Applications can be submitted to the facility during the whole year according to the procedure described on the web site of the Centre : http://www.wnmrc.comProject ManagerDr. H. Van As, Wageningen NMR Centre, P.O. Box 8128, Wageningen 6700 ET, P.O. BOX 8128, 6700 ET Wageningen, The NetherlandsTel: +31-317-482034/482044Fax: +31-317-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Development of an oral Helicobacter Pylori vaccine'.

assistant: **Concept**

Helicobacter pylori infection is highly prevalent worldwide and is an important cause of gastritis, peptic ulcer disease, and significantly gastric cancer. Because eradication requires treatment with multidrug regimens, there exists a very strong need for a vaccine to prevent initial infection.Immunization with H pylori protein subunits in humans has shown adjuvant-related adverse effects and only moderate effectiveness. However, with much greater knowledge of the molecular basis of infection and having learnt lessons from previous vaccine developments, the current consortium have drawn together three strand that are considered critical to the development of an effective vaccine:-Powerful, safe and multivalent antigens-Powerful, safe and multi-acting adjuvants-Powerful, modular and flexible oral vaccine delivery systemAll three of the above innovative technologies have been proven to be effective in doing what they are required to do, namely:-Antigens – produce antibodies against a number of key H pylori bacterial components-Adjuvants – stimulate the immune cells to produce significant numbers of long lasting antibodies-Delivery – formulate antigens and adjuvants together and target the stomach and intestineThis consortium (HELICOVAXOR) uniquely converges all three into a true vaccine with real potential to protect from H pylori infection. The vaccine is being designed for oral administration, efficacy, safety and temperature stability.This consortium has assembled leading academic, industrial and regulatory groups, the activities of which will be coordinated to perform analysis of the formulations, efficacy and safety testing of the vaccines and the preparation of a regulatory dossier, all required before the product can enter human clinical studies.If successful in pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Virtual tongue to predIct the oRganoleptic profile of mediterranean IngredienTs and their effect on hUman hOmeostasis by means of an integrated compUtational multiphysicS platform' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

VIRTUOUS is a virtual tongue made by an integrated computational framework able to screen food for natural ligands targeting taste receptors. The proposed intelligent algorithm, by integrating drug discovery techniques, machine learning classifiers, algorithms for big data, cloud computing, and experimental data will predict the organoleptic profile of a specific food based on its chemical composition. The outcomes of this research will shed light on the mechanisms driving the information transfer from the chemistry level, where food molecular constituents bind taste receptors, toward a cascade of molecular, supramolecular and cellular events emerging as an elaborated sensation which strongly contribute to the food organoleptic profile. The joint exchange programme involves 9 participants from 4 countries: Italy, Greece, Spain, Switzerland. Participants are both from academic (4 beneficiaries) and non-academic (5 beneficiaries) sectors. The balance between academy and industry and the interdisciplinary nature of the Consortium will grant a unique stimulating environment for researchers involved in the projects.Relevance of the program is identified at European and worldwide level, both for academia and industry. The idea of conceiving a taste predictor to be applied on European food products will boost and widen European food market at global level. The VIRTUOUS tongue may be also thought has an “food computer aided design tool” for EU food technology. For example, based on taste prediction the VIRTUOUS platform may be used in the future to predict the results of a specific grape graft. The Virtuous tongue may be also combined with other technologies to enhance precision agriculture. The VIRTUOUS research also links taste receptors’ activation to the activity of nuclear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Integrated in situ corrosion test of alpha-active high-level waste glass - phase 2'.

assistant: **Innovation**

Reprocessing of spent fuel yielded already more than 1, 150 cubic metres of COMEGAHLW glass. Geological disposal of vitrified waste is worldwide studied as a safe option. Long-term predictions of the glass performance are based on results from laboratory tests. Especially the public experiences these predictions as unreliable, since derived from irrealistic labotory tests". In the proposed project, the reliability of the predictions will be evalued by confrontation with the results of an in situ corrosion test of alpha-active COMEGA HLW glass, performed in realistic conditions (temperature, gamma radiation, backfill materials). Three corrosion tubes will be operated. Both the global glass dissolution and the specific radionuclide release and migration will be measured. If in the situ results agree with the laboratory results, the in situ test will be a small scale demonstration test of the good of the COMAGA HLW glass."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Novel Handheld Ultrasound Medical Imaging Probe: Prototyping, Initial Validation and Business Development' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The LucidWave Project introduces a low-cost, very capable, handheld ultrasound probe for medical imaging based on an entirely new ultrasound technology. It aims to provide a light, but powerful imaging tool to a wide range medical professionals for bed-side, point-of-care, office and operating room diagnostics.  Doing so it will bring the well-known capabilities of classic ultrasound imaging closer and faster to the patient, helping not only radiologists to make better decisions, but also GP?s, nurses, veterinarians.  Consequently, much time, costs and misdiagnosis will be saved for patient and physician.The project has to following objectives: (I) Starting at TRL 4, develop and deliver 2 full functional prototypes with all parts integrated into one slim device. The capabilities will largely surpass those of current handheld devices. (II) Validate the prototype?s performance in a clinical evaluation. Together with the foundations of a Quality Management System (ISO 13485), it will provide a head start for a later formal Clinical Validation according to the new Medical Device Regulation. (III) Build an entrepreneurial and complementary team by inviting entrepreneurs-in-residence. (IV) In preparation of a start-up a complete and quantified business plan will be created, building on a solid Value Proposition Canvas (incl. user-centric design) which is developed into a Business Model Canvas. LucidWave fits well into the EIC Transition Programme since it aims to develop a mature proof-of-concept (validated against state-of art) into a prototype ready for Clinical Validation and for scaling-up of the manufacturing. The technical part is complemented with a business strategy for a new and healthy start-up. It addresses one of the key challenges and priorities of Europe, i.e. t