RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Reliable Operating Systems for Embedded Systems'.

assistant: **Concept**

Current computer software, including operating systems, have poor reliability and security. Unfortunately, this lack of reliability also applies to embedded systems, that is physical systems controlled by a microprocessor, such as those used on cars, airplanes, MRI scanners, pacemakers, insulin pumps, cameras, set-top boxes, mobile telephones, appliances, and many more. Software failures in these devices can have catastrophic effects. Bugs in the code of the Therac-25 and Cobalt-60 radiation machines killed several dozen people due to overdoses of radiation and bugs in the software of the Prius’ software-controlled braking system have led to fatal accidents, for example.The related ERC Advanced Grant was about redesigning operating systems to make them more reliable, with a focus on desktop systems.In this project we want to use the results of the research to try to make embedded systems more reliable and then move toward commercializing the software. One area of interest to us is embedded systems that are currently or will soon be networked. It will not be too long before, say, next generation pacemakers get networking capability to send patient monitoring information to the hospital in real time. Such systems need to be extremely reliable and protected against hackers. They also need to be updatable while they are running. No current embedded systems provide this kind of capability, but we think we can provide it and we believe there will be a market for it. The first step is to port our desktop system to the ARM processor, which dominates the embedded systems world, and make a prototype to show potentially interested parties. At that point we will be able to see if the project is commercial viable. Before the ARM port and a sample application have been done, that is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Investigation of ob gene expression in immortalized human brown adipocytes' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

This project aims to determine the regulation of ob gene expression in immortalized human brown adipocytes. The ob gene product, leptin, is a putative hormone that acts on hypothalamic centres, recently shown to induce weight loss in obese mice. Leptin functions as a central component in the body weight regulatory system, including insulin, B3-adrenergic receptor and hypothalamic centres. Since obesity constitutes the greatest health problem in Western society, the elucidation of leptin regulation is of considerable scientific and social relevance. A unique cellular system of immortalized human brown adipocytes forms the basis of this work Northern blot, PCR and nuclear run-on analyses will examine the dependence of ob gene expression on insulin and various B3-adrenergic ligands. The ob gene and its regulatory regions will be examined to define enhancer and transcription elements. Cell lines with a mutant B3-adrenergic receptor will be generated and selective inhibitors/activators of signal transduction pathway components will be employed to define intracellular processes in ob gene expression.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DPP9 degradation-induced pyroptosis for treatment of acute myeloid leukemia' to be submitted under Horizon Europe.

assistant: **Abstract**

Dipeptidyl-peptidase 9 (DPP9) is a proline-selective serine protease that belongs to the peptidase S9 family. During recent years, DPP9 inhibition has shown to cause pyroptosis, selectively in acute myeloid leukemia cells. Pyroptosis is a lytic form of programmed cell death, that has mainly been observed in immune cells. The process typically recruits and activates other immune cells and inflammatory mediators, causing a localized activation of the innate immune system. This is particularly appealing for leukemia treatment, because the immune-response to leukemic cells is typically severely subdued. Recent mechanistic insight suggests that native DPP9 suppresses pyroptosis through a stabilizing protein-protein interaction (PPI) with the NLRP1 inflammasome sensor. Furthermore, DPP9 inhibition with small molecules only has a mildly destabilizing effect on the [DPP9-NLRP1] PPI. This proposal suggests the targeted clearance of DPP9 from the cytoplasm in acute myeloid leukemia cells to cause pyroptosis through enhanced NLRP1 activation. PROTACs and AUTACs are heterobifunctional molecules that mediate the degradation of a protein of interest (POI) by hijacking cells own proteasome and autophagic system, respectively. The implementation of PROTAC and AUTAC technologies for targeted clearance of DPP9 and consequent pyroptosis induction in acute myeloid leukemia cell lines is proposed in this project. PROTAC and AUTAC molecules will be designed and synthesized, followed by in vitro evaluation of their cell permeability, DPP9-engagement, DPP9 clearance potency and selectivity, and dose/time dependence of DPP9 clearance. Furthermore, a comparison of the pyroptosis signatures of PROTACs, AUTACs and DPP9 inhibitors will be performed. Overall, this proposal can provide a superior the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Spin-charge conversion in highly resistive spin-orbit materials' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

With the current technology of transistors reaching characteristic sizes of a few nanometers, and heating effects becoming more severe, the regular functionality of processors is at stake. In the next few years, new technologies are required to sustain the increasingly high demands imposed by the consumer electronics industry worldwide. Among the wide range of proposed options, spintronics is considered to be one of the leading candidates to fill this gap, backed by recent proposals for spin-based computation using magnetoelectric spin-orbit devices. In these devices, the magnetic state of a ferromagnetic material is read through the conversion of spin currents in charge currents, where two resistance levels can be unambiguously detected depending on the magnetization direction of the ferromagnet, i.e. a “1” and a ”0” state. The main goal of SPECTER is to find the most suitable material exhibiting large spin-to-charge conversion efficiencies combined with large resistivities, allowing the generation of high output voltages for a subsequent writing step. To achieve this result, a careful balance between adequate materials beyond the conventional high spin-orbit coupling metals, and device fabrication of nanostructures that maximize spin-to-charge conversion detection needs to be achieved. With this proposal, we want to explore nanostructured topological insulators and correlated oxides fabricated by industry-friendly techniques, such as sputtering and e-beam lithography, while benchmarking them for future spin-based devices. This way, SPECTER not only poses a revolutionary step towards the next generation of processors, but also aims at acquiring scientific knowledge with technological applications to be useful for both academia and industry. Moreover, the ultimate goal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ONLINE ANALYSIS TOOL FOR THE OPTIMIZATION OF SOCIAL MEDIA CAMPAIGNS' (OPTIMIZR).

assistant: **Innovation**

For the first time in history, spending on Internet advertising surpassed newspaper spending, a trend that will increase in the future. The large bulk of this spending was invested in non-traditional social media marketing programmes, involving multiple channels such as Twitter, social networks, blogs and more. Alongside the growth of social networks the birth of a new methodology of analysis: Social Network Analysis. This methodology, based on graph theory and social analysis, is of increasing importance in Marketing 2.0. As online marketing has shifted away from a model based on Click-through rates and impressions and has moved towards a less measurable model – with multiple transmitters of information (tweeters, bloggers, fans, etc.) it is becoming increasingly difficult to measure ROI for these types of marketing actions. The product to be developed during the project will be a SaaS system that will help companies (or their social media agencies) to increase the visibility of their products, services or brands, by means of:1. Maximizing the impact of social media campaignsBased on a previous analysis of the network structure of main social network services (Twitter, blogs and Facebook) and a deep content-based information diffusion analysis, users will learn to:Identify influencers that could help to improve the diffusion of messagesIdentify online communities that best fit their campaign target, and focus the actions on them.Increase engagement with these actions, identifying the factors that improve involvementPredict the social spread of the campaign, enabling the adjustment of the actions according to real performance and contrast with expectations.2. Monitoring social media marketing impactThe aim will be to establish metrics for evaluate the efficiency of an o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Miniaturized System for Screening of Primary Cells based on Droplet Microarray' to be submitted under Horizon 2020.

assistant: **Abstract**

Current cell screening systems based on microtiter plates are mainly used to perform drug discovery experiments. However, performing a larger number of therapeutic tests on patient derived (primary) cells is yet impossible due to the high consumption of reagents and cells when using microplates. In the clinical context, personalized drug screenings for optimal medical treatment are not possible due to the scarcity of precious primary cells. In pre-clinical drug discovery, the extremely high cost of primary cells limits the innovation potential as researchers hardly have access to screening models which are relevant for human physiology. The possibility to use scarce cell types like primary cells or stem cells therefore is the future of basic life science research, drug discovery (replacing animal models) as well as personalized medicine applications (individual precision therapies) and will have significant impact for a healthy society. Further miniaturization of current assays would inevitably allow the wide use of scarce cell types and at the same time reduce costs, increase throughput, and increase biological relevance of screening results. DMA allows researchers and clinicians to perform meaningful experiments with primary cells and circulating tumor cells – alternative technologies hardly work with low cell numbers.EC funding Phase 2 will allow Aquarray to mass produce its offer – the DMA Cartridge and also the disruptive Cell Screening System that integrates the DMA Cartridge with a nanoliter dispenser, an incubator and a read-out apparatus. Aquarray’s disruptive business model will employ a B2B direct sales of the DMA Slides and the Screening System, and at the same time sales can be maximized through partnerships with companies selling liquid nano-dispensers suc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Strain-graded MAGnetoelectric composites based on NanoporoUS materials for information and biomedical technologies' in the context of a Horizon 2020 call.

assistant: **Objectives**

Magnetoelectric (ME) composites have the potential to revolutionize current nanotechnologies due to their ability to simultaneously respond to external magnetic and electric stimuli. However, archetypical ME materials prepared on rigid supports show either small effects due to the clamping with the substrate (e.g., Si wafers) or require of extremely high voltages (in case ferroelectric –FE– substrates are employed). To overcome these drawbacks, MAGNUS proposes a comprehensive research program built on the disruptive idea of using strain-gradient (i.e., flexoelectricity), instead of homogeneous strain, to boost the properties of ME composites deposited onto rigid substrates. The project encompasses new strategies to grow ‘mechanically flexible’ nanoporous magnetostrictive materials (FeGa, FeCo, Co ferrite) and fill them with FE polymers (P(VDF-TrFE)), rendering new functionally graded composites, operated with magnetic/electric fields, that will surpass classical compositionally-graded materials. The project aims at using these composites for (i) ME (wireless) bone tissue engineering and (ii) functionally-graded magnetic recording media. MAGNUS will take advantage of (i) my previous experience on electrodeposited Fe-based alloys and spin-coated FE polymers, (ii) the strong background of the main Host Institution (UAB) on magnetism and (iii) the expertise of the Partner Organizations on ME materials for biomedicine (ETH Zürich) and the growth of porous oxides (Univ. Cambridge). MAGNUS will bring interesting cross-cutting outcomes in the field of magnetoelectricity, exploiting strain-gradient mediated ME effects to an unprecedented extent and settling the grounds to consolidate the use of these frontier materials in the newly launched “Horizon Europe” Framework Programme (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'INNOVATIVE ROUTES TO NOVEL CATALYST FOR UTILISING RENEWABLE ENERGIES' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The alarming increase in the amount of green-house gases in the atmosphere and its severe climate consequences is a fact that will put life on Earth to serious risks if no quick action is taken on a global scale. C2CAT expertise in catalysis for H2 production, storage and recycling of CO2 will come into play. Contribution to the H2 economy and CO2 reduction will be achieved at C2CAT via design, development and commercialisation of cost-effective alternative catalysts suitable for sustainable processes.


**Keywords:** Marketing, entrepreneurship, business strategy, collaboration, communication, technology management
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The structure of aqueous electrolytes - experiment and theory' under Fourth Framework.

assistant: **Concept**

Research objectives and content Experimental studies will be carried out on representative 1:1 and 2:1 aqueous electrolytes using three experimental methods: Neutron diffraction with isotopic substitution (NDIS), extended X-ray absorption fine structure (EXAFS) and anomalous X-ray scattering. The primary objective will be to obtain information on the ion-ion correlations and on ionic hydration as a function of concentration, dielectric constant and density. The results will be compared with predictions based on current theories of model electrolytes and computer simulations of ionic hydration. A quantitative comparison will be carried out of the relative accuracy of the various experimental techniques used. Training content (objective, benefit and expected impact) The applicant will be trained in the techniques of NDIS, EXAFS and anomalous X-ray scattering at ILL (Grenoble, France), ESRF (Grenoble, France) and ISIS (RAL, UK). She will also learn the present status of the theory of aqueous electrolyte solutions. This programrne will provide an excellent grounding for future research in both experiment and theory. Links with industry / industrial relevance (22) Aqueous electrolytes are important in many natural processes in biochemistry, geology and solution science. A better understanding of their fundamental properties will be of interest to developments in the chemical and pharmaceutical industries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Prevalance characterisation & prevention of latent autoimmune diabetes in adults (lada) in europe (action lada)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

A substantial proportion of patients with non-insulin requiring diabetes progress to insulin therapy. Many cases, despite being adults, have immune and genetic features of autoimmune type 1 diabetes. Such adult autoimmune non-insulin requiring diabetic patients probably comprise the majority of cases of autoimmune diabetes in Europe and their condition is described as latent autoimmune diabetes of adults (LADA). This proposal aims: 1 ) to define the prevalence of LADA across Europe by testing non-insulin requiring diabetes patients for antibodies to glutamic acid decarboxylase; 2) to characterise LADA in terms of genetic, immune and metabolic features, and 3) to prevent or delay progression to insulin dependence in LADA using a immune modulation therapy with a heat shock protein altered peptide (Diapep 277). The double-blind randomised prevention trial will determine in a group of recent onset LADA patients whether therapy with Diapep277 can modify the natural history of the disease. Such therapy, if successful in reducing progression to insulin dependence, could be used to prevent autoimmune type 1 diabetes in children.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nephilid spider phylogenetics as a test for antagonistic coevolution of sexes' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The recent literature does not support arms race models in spiders, but my preliminary data on nephilid spiders (Nephilidae Simon) suggest otherwise. Spiders are ideal for studying genital divergence because that is often the only salient trait that differ s; all others (life-history, reproduction) are thus held constant. Evolutionary questions are best asked in the context of a solid phylogeny. Here, we propose to test a new morphological phylogeny for nephilids (and thus the evolution of sexual traits) wit h genomic data. The combination of morphological and genomic data should provide the best context in which to analyse currently available behavioural evidence.The three lines of evidence together form the basis for a proposed long-term collaborative inter national research programme that unites three spider biology experts with different expertises. This project will reintegrate me into European science after six years of research in the USA. Spider genitalic evolution contrasts with better-known animal models, and may strongly challenge existing models of sexual selection and related evolutionary processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Design and development of imaging device, with on-line access, for molecular analysis of human biopsies to permit genomic disease management.' in the context of a Fifth Framework call.

assistant: **Objectives**

Initiate planning (market analysis + patents survey) and select partners to design and develop a prognostic device, with results available on-line, that would perform biochemical and histological analysis, at the single cell level quantitatively with critical genetic indicators for certain cancers, cardio- osteoarthritic, pathological- and muscular degenerative diseases. Critical parameters vary with disease; often they are gene-related. Device: § uses in site hybridisation + ELISA to correlate nucleic acid changes to protein. § Examines biopsies to compare normal with diseased tissue. § Establishes sequence and concentration standards + controls sampling errors. Not only are sampling procedures and measurements standardised, but also the data are fed, anonymously, into a common pool for statistical met analysis, to improve prognosis and treatment - a major consideration for subscribers.