RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innovative FRET-based toolkit for screening of drugs to fight miRNA-related diseases and its use in the development of cancer treatment with miRNA-96 as a therapeutic target' in the context of a Horizon 2020 call.

assistant: **Objectives**

The overall goal of this project is to develop a universal FRET-based toolkit for screening of drugs targeting microRNA (miRNA). Specific outcome will be a high-throughput assay for finding drugs targeting miRNA-96, a tumor-suppressing miRNA in pancreatic cancer cells. FRET is the technique of choice and recently, Prof. Marcus Wilhelmsson, Chalmers University of Technology (CHALMERS; project main supervisor) pioneered the development and photophysical characterization of fluorescent base analogues (FBAs) optimized for high-resolution FRET analysis of nucleic acid systems. There is an urgent need in pharmaceutical industry for an in vitro, cell-free, pre-miRNA-small molecule interaction high-throughput assay and also to increase the understanding of the nature of miRNAs. In this project, the unique FRET FBAs will be utilized to develop such assays and to provide new knowledge regarding miRNA structure, dynamics and interactions with other biological molecules or drugs. Apart from taking on the new research field stated above and developing my professional skills, I will bring in new competences to CHALMERS in RNA biochemistry (from the University of Warsaw and Max Planck Institute in Göttingen). Moreover, as part of my training, I will carry out research at AstraZeneca (AZ) and Gothenburg University (UGOT) through secondments. CHALMERS/AZ/UGOT have an established collaboration and I will take full advantage of their R&T capacities in order to gain interdisciplinary and intersectoral expertise as well as to master my skills in scientific communication, scientific writing, coordinating research projects, results exploitation, critical assessment, mentoring, supervision, presentation and networking with other researchers across the globe. This MSCA Postdoctoral Fellowship w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Rethinking the Welfare State under Political Constraints in a Changing World' (RESTATE) under Horizon Europe.

assistant: **Objectives**

Initially intended to shield individuals from adverse macroeconomic shocks, welfare programs such as social security have grown significantly over time, evolving into politically entrenched entitlements. Demographic changes, including declining fertility rates and increasing life expectancy, have further fueled their expansion, raising fiscal pressure. While retrenchment reforms are recognized as essential for economic sustainability, strong public support for welfare programs often renders them politically unviable.How should an optimal welfare state be designed in a changing world to balance economic sustainability and political viability?RESTATE will develop a new theoretical framework to rethink the design of an optimal welfare state, accounting for intergenerational redistribution and addressing political frictions that arise from the fiscal authority’s limited ability to enforce participation, thus departing from traditional frameworks that assume mandatory programs. The optimal welfare state must balance a fundamental trade-off between maximizing welfare, incentivizing participation, and honoring entrenched entitlements.RESTATE will tackle this complex trade-off across diverse fiscal domains explored in three interconnected work packages, combining theoretical and empirical analysis. Work Package 1 will study how optimal social security systems can address the long-term sustainability challenges posed by demographic aging while mitigating political frictions. Work Package 2 will examine the optimal management of public debt, emphasizing its role as a hedge under political limits on raising primary surpluses. Work Package 3 will analyze the role of optimal public investment in securing the fiscal sustainability of social security systems and public debt.By providi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Single Cell Imaging of Gene Activation during Oxidative Neuron Death: Towards Quantitative Systems Approaches'.

assistant: **Concept**

Ischaemic stroke and neurodegenerative disorders are leading causes of death and disability and their incidence is rising rapidly due to increases in European life expectancy. Excessive apoptosis is pathogenic when it concerns post-mitotic cells such as neurons; for instance in stroke or neurodegenerative diseases. Oxidative stress is a major contributor to ischemic and neurodegenerative processes; however, the molecular mechanisms and biological switches that determine outcome, i.e. neuronal tolerance or neuronal apoptosis, in response to oxidative stress are not fully characterised. This aim of this project is to analyse these events at the single cell level. The applicant has an excellent track record in the molecular analysis of pro-apoptotic gene activation in response to oxidative stress. Here, we propose to monitor and quantify the activation of cytoprotective (ARE- and HSE-containing) vs. pro-apoptotic (BIM) gene expression in neurons and astrocytes in real-time using GFP-based reporter assays and employing quantitative confocal and epifluorescence microscopy approaches. The quantitative single-cell data obtained will be incorporated into mathematical models of apoptosis activation developed by the host laboratory. The suggested fellowship will advance our understanding of this critically important biological process by allowing for a quantitative analysis of this signalling/gene activation network. The fellow will strongly complement the research activities of the host laboratory, and most importantly, will acquire new skills and be exposed to a unique interdisciplinary training programme. Furthermore, this work could provide important information for the development of new therapeutic strategies for ischemic and neurodegenerative disorders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'The Geometry of Scattering Amplitudes'.

assistant: **Concept**

This project aims to explore an exciting discovery in mathematical physics, a new algebraic approach to perturbative gauge theory, the colour/kinematics duality, which also provides a connection between gauge theory and gravity. This duality says that the quantum-mechanical amplitudes for particle scattering in gauge theory depend on the momenta and polarisation of the scattered particles (kinematics) in a way that mirrors the dependence on the “colour”, the internal degree of freedom of gauge theories. Kinematics and colour appear, at first sight, in a very different manner, so this strongly suggests that the traditional methods of quantum field theory give us a very limited understanding of gauge theory amplitudes, and many recent results have strengthened this idea. The colour/kinematics duality has the potential to provide new connections between mathematical physics and other areas of mathematics, such as differential and algebraic geometry, twistor theory and graph theory. This proposal is perfectly suited to the expertise of the Mathematical Physics Group of the Mathematical Institute of the University of Oxford, which is the host institution for this project, and to my own research experience across different subjects in mathematical physics, from general relativity and string theory to scattering amplitudes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Critical Action Planning over Extreme-Scale Data' in the context of a Horizon Europe call.

assistant: **Objectives**

The vision of CREXDATA is to develop a generic platform for real-time critical situation management including flexible action planning and agile decision making over streaming data of extreme scale and complexity. CREXDATA develops the algorithmic apparatus, software architectures and tools for federated predictive analytics and forecasting under uncertainty. The envisioned framework boosts proactive decision making providing highly accurate and transparent short- and long-term forecasts, explainable via advanced visual analytics and accurate, real-time, augmented reality facilities. To achieve its vision, CREXDATA will develop a next generation Prediction-as-a-Service (PaaS) system where action planners will easily register their multimodal data stream sources and compute resource federations and graphically design predictive analytics workflows including (i) data ingestion, fusion, (ii) simulation, (iii) federated learning for pattern extraction and (iv) multiresolution forecasting operators. Decision makers will receive back extremely precise forecasted representations of future worlds reasoned about using transparent AI facilities and with reduced complexity via visual analytics and intuitive augmented reality provided on-site or remotely. The CREXDATA architecture incorporates 10 exploitable assets based on cutting edge research, which will significantly outperform the current state of practice in respective fields.  CREXDATA will be evaluated in three use cases where real-time critical action planning and timely decision making are of utmost importance: i) maritime domain, for forecasting hazardous situations at sea and impose safer navigational routes, ii) weather emergency management, to allow authorities and first responders proactively act so as to avoid or re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Marine Protected Areas as tools for FISHeries management and conservation' in the context of a Sixth Framework call.

assistant: **Objectives**

The present research proposal has three general objectives: I) To investigate the potential of different regimes of MPAs in Europe as measures to protect sensitive and endangered species, habitats and ecosystems from the effects of fishing. II) To develop quantitative methods to assess the effects of marine protected areas. III) To provide EU with a set of integrated measures and policiy proposals for the implementation of MPAs as fisheries and ecosystem management tools. Objective I is to be completed through the compilation, comparative analysis, and interpretation of data issued from selected case studies amongst EU MPAs, considering ecological (WP1), fishery (WP2), and socio-economic (WP3) aspects (the latter making the distinction between consumptive, non-consumptive, and institutional benefits and costs). In all cases, data already exist, or, in some cases, will be sampled in situ to complete the inputs to subsequent tasks. Case studies will be selected among the most studied European MPAs after a first typification, considering the following major management regimes: i) no-take zones, ii) partial reserves, and iii) species-oriented reserves. A second source of information will emerge from meta-analysis of published results (both in the European context, and worldwide). Objective II is being approached by providing and evaluating impact indicators of MPA effects (WP4) (considering ecological, fisheries, and socio-economic effect), and through the use of bio-economic modelling (WP5) (the latter serving also to complete the depiction of scenarios defined by different protection regimes, as empirically observed from previous WPs). Objective III will consist on, based on the results of prior WPs, providing management guidelines for the implementation, management, moni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Identity matching from still images without face information' (StillNoFace).

assistant: **Innovation**

In computer vision, human identity matching from images and/or video has been an active research topic for more than two decades and its popularity is increasing with the increase in computing power. The state of the art techniques are based on face images and gait recognition from long video sequences. However, in many real applications only some static images of the subject may be available where face information is missing (e.g. posterior views). These scenarios have not been addressed by the research community as they are difficult to handle. In this action, we propose a method for matching identities from a set of 2D images of a person without any facial information. The method consists of two steps: at first, the human body is modelled by a 3D articulated model whose pose is estimated by its 2D projections onto the images. Then, biometric features are computed by fitting 3D deformable models to the image data, thus capturing the form and size of the main parts of the anatomy. The overall framework works under a probabilistic framework, with a learning step, in order to encode pose and anatomy variations between a set of individuals that are to be identified.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Improved ship design for marine safety: extreme loads effects and h ydroelastic coupling' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Objectives and content European Marine Industries are now strongly concerned by integrated ship design including safety assessment (industry priority in Maritime Industry R&D Master Plan as well as in Task Force Maritime Systems of the Future). For the extreme accidental hydrodynamic loading and associated hydroelastic response, there is a strong need for reliable prediction tools/methodologies. The industrial research effort in SEAWORTH is aimed to develop analyses and design tools that are now necessary to produce new ships (competitive engineering) satisfying the most stringent safety and environmental regulations and the most demanding of markets (inside Europe in short sea shipping, and outside Europe for South East Asia). This will benefit to the European Maritime Industries, which will increase their capabilities to produce and operate ships at the right safety level. In the present project, industrial design scenarios will be defined by partners end-users and a Classification Society for four types of ship (task 1). To address the problem of extreme hydrodynamic loads (local slamming impacts loads, global hydroelastic response), there will be numerical analyses with existing software (hydrodynamics, structural analyses and hydroelastic coupling with finite element and finite difference methods) and experimental tests (seakeeping in model basin and water impact tests on bow shapes), with particular concern on fluid-structure interactions (tasks 2 and 3). A database of these results will be built and integrated within an expert system structure open to other types of ship (task 4). For practical purposes of design work, a predictional methodology for extreme loads will be derived from these basic analyses, through deterministic and statistical approaches (task 5).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Earth Observation based services for Monitoring and Reporting of Ecological Status' in the context of a Horizon 2020 call.

assistant: **Objectives**

EOMORES (Earth Observation-based Services for Monitoring and Reporting of Ecological Status) aims to develop new highly efficient commercial services for operational inland and coastal ecological water quality monitoring. Inland and coastal water bodies constitute essential components of ecology and biodiversity, they buffer climate change and influence many aspects of economy (recreation, fisheries) and human welfare (e.g. drinking water supply). Knowledge about the state of these waters is therefore of great importance. This is recognized by the Water Framework Directive (WFD) requiring the EU member states to monitor and improve the status of these water bodies. EOMORES will develop fully-automated commercial, reliable and sustainable services based on the integration of Earth observation (Sentinel 1, 2 and 3), in situ monitoring using optical in situ sensors with integrated GNSS positioning, and ecological modeling. The validated data from these components will be flexibly combined into higher-level products to fit the users’ information needs. Three service concepts are envisaged: 1) operational water quality monitoring and forecasting for operational water management, 2) implementation of validated EO-based water quality indicators for WFD and other reporting and 3) historic compilation of data for specific ecological analysis. The target users of EOMORES are international, national and regional authorities responsible for monitoring and management of water quality and for WFD reporting. Additional targeted users are private entities dealing with water quality. Thirteen users from six countries have committed to collaborate with the consortium to define and evaluate the EOMORES services. The services are expected to result in lower operational costs, more reliable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'From longitudinal proteomics to dynamic individualized diagnostics' (DynaOmics), addressing dissemination and exploitation.

assistant: **Impact**

Longitudinal omics data hold great promise to improve biomarker detection and enable dynamic individualized predictions. Recent technological advances have made proteomics an increasingly attractive option but clinical longitudinal proteomic datasets are still rare and computational tools for their analysis underdeveloped. The objective of this proposal is to create a roadmap to detect clinically feasible protein markers using longitudinal data and effective computational tools. A biomedical focus is on early detection of Type 1 diabetes (T1D). Specific objectives are:1) Novel biomarker detector using longitudinal data. DynaOmics introduces novel types of multi-level dynamic markers that are undetectable in conventional single-time cross-sectional studies (e.g. within-individual changes in abundance or associations), develops optimization methods for their robust and reproducible detection within and across individuals, and validates their utility in well-defined samples. 2) Individualized disease risk prediction dynamically. DynaOmics develops dynamic individualized predictive models using the multi-level longitudinal proteome features and novel statistical and machine learning methods that have previously not been used in this context, including joint models of longitudinal and time-to-event data, and one-class classification type techniques.3) Dynamic prediction of T1D. DynaOmics builds a predictive model of dynamic T1D risk to assist early detection of the disease, which is crucial for developing future therapeutic and preventive strategies. T1D typically involves a relatively long symptom-free period before clinical diagnosis but current tools to predict early T1D risk have restricted power.The objectives involve innovative and unconventional approaches and address