RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bioelectricity and gene regulation interplay in embryonic development' (ELECTROGENDEV).

assistant: **Concept**

Turning a single cell into a complex organism is a key biological process usually studied through molecular signals that guide cell specialization and tissue development. Although chemical gradients and transcription factors have been extensively studied, recent research highlights the critical role that bioelectric signals play in embryonic patterning and gene regulation. These bioelectric signals are produced when charged ions flow through certain proteins, such ion channels and pumps, and pass through the cell membrane. Unfortunately, because these two disciplines are frequently investigated independently, the precise interaction between bioelectric signals and gene control throughout embryonic development remains substantially unknown. The objective of the ELECTROGENDEV project is to unite these two fields and present an exhaustive explanation of how gene regulation and bioelectricity work together to govern embryonic development in the ascidian Ciona intestinalis. Due to its quick growth and simple body plan, this marine invertebrate has become an invaluable model organism for researching the molecular underpinnings of early embryonic development.In this project, I will map the bioelectric landscape during ascidian embryogenesis using genetically encoded voltage indicators and ion sensors. Parallelly, I will study a variety of ion channels, which are responsible for establishing that bioelectric landscape, and determine which ones are co-expressed with important developmental genes. Integrating these findings will pinpoint important regulatory nodes in the development of embryos, which I will then modify pharmacologically or genetically to create a full model of how bioelectric signals interact with the genetic program during embryo development. The findings have t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Virtual Pathological Heart of the Virtual Physiological Human' in the context of a Seventh Framework call.

assistant: **Objectives**

Heart failure accounts for almost a quarter of all admissions to hospital for cardiovascular events, has a high mortality (median survival around 18 months), and places a great burden on all healthcare systems, with estimated direct costs of £905m (?1350m) in the United Kingdom in 2000, 2% of total NHS expenditure.VPH2 aims to develop a patient-specific computational modelling and simulation of the human heart to assist the cardiologist and the cardiac surgeon in defining the severity and extent of disease in patients with post-ischemic Left Ventricular Dysfunction (LVD), with or without ischemic mitral regurgitation (IMR). Specific computational methods will allow clinical decision making and planning of the optimal treatment for left ventricle-valve repair. The goal is not only to deploy a fully validated technology to partner clinical institutions, but also to develop a sustainable business model associated to it.The associated technological aim of the project is to deliver the most advanced software application framework for the development of computer-aided medicine in cardiology and cardiac surgery available in the world, going beyond the state of the art of available models.This goal will be achieved by integrating some of the leading Open Source software in the area of computer-aided medicine and of computational bioengineering. This framework will be used by VPH2 to realise its objectives, but also by any other future project (academic or industrial) aiming to improve or extend VPH2 objectives.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sigec nanostructures: a new path to silicon based optoelectronics' in the context of a Fifth Framework call.

assistant: **Objectives**

The requirement for smaller devices puts high demands on the knowledge and skills of comprehensively educated physicists and engineers. The proposed network has the goal to improve the scientific training of at least 9 PhDs and post-doctoral researchers by providing access to research infrastructure at institutions of high reputation in the field. MPI, UniLinz, PSI and INFM provide access to large-scale research facilities (clean rooms with line for Si processing, synchrotron centres). The knowledge, the experimental and theoretical expertise and the technological skills of the fellows will be expanded. This will be appealing for industry, and thus enhance the career prospects of the young researchers. The network provides several routes to accomplish these training goals. Not only shall samples be exchanged, but, more importantly, young researchers will be sent to the different laboratories. Besides the opportunity to participate in international conferences, there will be regular meetings within the network. Every 4-6 month the young researchers will organize a meeting to exchange data and to plan the consecutive experiments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Regulation of Processing Body Composition, Function and Fate during Different Stresses at Endoplasmic Reticulum-Membrane Contact Sites'.

assistant: **Concept**

One of the first responses to eukaryotic cellular stress is the formation of cytoplasmic granules like processing bodies (PBs) and stress granules (SGs). PBs are membrane-less structures that are dynamic in their assembly/disassembly and composition depending on the type of stress that they encounter. While glucose starvation is the main stress applied to study PB formation and dynamics, much less is known about PBs under other stresses, especially endoplasmic reticulum (ER) and mitochondrial/lysosomal stresses. We propose to study the formation, content and dynamics of PBs under ER and mitochondrial/lysosomal stresses, together with their turnover (autophagy/dissolution) during stress recovery. I plan to use pharmacological and acute genetic interventions to induce stresses. PBs will be purified according to the established protocol in the laboratory, which enables subsequent Liquid chromatography-mass spectrometry (LC-MS) analysis for proteins and RNA-sequencing for the RNA content. Probing stress response further, we will also perform total RNA-sequencing and Ribosome-profiling. The fate of specific sets of mRNAs will be determined by FISH-IF and RNA decay analysis, thereby identifying the signals effectuating PB localization and fate (storage or decay) during ER and mitochondrial/lysosomal stress. The study will be extended to check conservation of PB stress response in mammalian cells. The proposed research will provide a holistic view on the pathways that are up- or down-regulated during ER and mitochondrial/lysosomal stress, the identification of common pathways between the different stresses and PB -mRNA and protein- turnover. This project will be of high impact in the fields of cancer, cell, and neuro biology.


**Keywords:** RNA decay, Endoplasmic Reticulum-Me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quantum Sensing with van der Waals Heterostructures based on hexagonal Boron Nitride' (BoNi-SENS).

assistant: **Concept**

The project idea is to implement a new quantum probe based on hexagonal boron nitride (hBN) containing spin defects to study the properties of artificially stacked two-dimensional (2D) materials and devices. The essential building blocks of such van der Waals (vdW) heterostructures are the quantum defects in hBN recently discovered by the PI and his team. These intrinsic lattice defects - negatively charged boron vacancies VB - can be optically spin-polarized and coherently manipulated, allowing the read-out of quantum information during the coherence time. Our experimental approach is based on coherent manipulation of the spin state using high-frequency pulse protocols, followed by optical readout to explore the adjacent environment, in particular by studying the local lattice strains, pressure, temperature and magnetic fields. The unique feature of hBN is its non-disturbing chemical and crystallographic compatibility with other vdW materials, which gains a new fundamental functionality with the embedded spin centres and allows sensing in heterostructures serving as a boundary itself. Optical readout will be extended by electrical control of spin and charge states, which is an unexplored area and a major step forward in the development of quantum applications of vdW heterostructures. We focus on i) the enhancement of VB emission and spin resonance contrast by coupling with plasmonic resonators to identify single defects never seen before, ii) the identification of the sources of spin decoherence of these defects, in particular the interaction with other electronic defects and hyperfine-coupled nuclear bath, and their bypassing, and iii) the exploration of semiconducting and magnetic heterostructures and electronic devices based on them. The project aims to establish 2D
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Aerial Situational Awareness for Every Firefighter' (Fotokite), addressing dissemination and exploitation.

assistant: **Impact**

Fotokite aims to provide firefighting and public safety teams with a new tool to safely and easily access aerial situational awareness information to help in their mission to save lives and preserve property. Fotokite has developed a vehicle-integrated and tethered UAV technology to deliver mission-critical information to firefighters during emergency response situations. Use of drones at the exploration of emergency zones is limited due to safety, regulatory, and technical capabilities. Drones that are piloted manually are prone to user error, unsafe in cities and around crowds of people, and do not scale operationally. Flight time is also a fundamental limitation, as free flying systems are generally limited to 20-30 minutes of flight time. Despite these disadvantages, traditional drones are increasingly used to improve Public Safety team operations.Fotokite’s tethered UAV systems can be launched from the fire trucks autonomously, with the single push of a button. Fotokite systems fly themselves and stream live thermal + visual video to firefighters on the ground, providing mission-critical situational awareness to help lifesaving operations. Fotokite has immediately created a substantial demand, proven by strong customer feedback and significant market uptake. Fotokite systems have successfully been implemented in live fire responses, search & rescue missions, and training exercises to help firefighting teams.Revenue is generated by selling hardware systems for an upfront cost plus an annual service contract subscription, which includes dedicated support, remote data accessibility for teams, and secure data management services. The requested grant is needed to develop scaled-up manufacturing processes and significantly accelerate market introduction with this game-ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Physical forces driving fibroblast-led cancer cell migration' (CAFFORCE) targeting Seventh Framework.

assistant: **Abstract**

Cancer cell invasion and metastasis remain the leading cause of cancer-associated death. It is now clear that invasion is not simply a cancer cell autonomous process but the result of complex interaction between tumour cells and their microenvironment. A number of studies have now shown that the presence of Cancer Associated Fibroblasts (CAFs) in the tumour microenvironment enhance cancer cell invasion within the surrounding tissue, thus highlighting the interaction between CAFs and cancer cells as a promising therapeutic target to counteract cancer progression. Recent evidence has established that CAFs are able to guide the collective migration of cancer cells. While the ability of CAFs to rearrange the matrix and favour invasion is well established, how CAFs guide the forward motion of cancer cells remains unknown. To decipher the biophysical features of this cellular interaction we propose here a multidisciplinary project to study the physical forces that drive fibroblast-led collective cancer cell migration. To achieve this goal, we will use novel techniques developed at the host laboratory to measure the physical forces that cells exert on each other and on their surrounding matrix. Next, we will combine these force measurements with genetic and biochemical interventions targeting the interaction between CAFs and cancer cells. As the collective movement of cancer cells into tumor microenvironment is the first step in the spread of metastatic cancer, deciphering the interplay between mechanics and biology at the CAF-cancer cell interface will bring crucial insight into metastatic processes and potentially new therapeutic targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'An adaptive peer-to-peer software Infrastructure for supporting collaborative work of human operators in emergency and disaster scenarios'.

assistant: **Innovation**

The WORKPAD project aims at building and developing an innovative software infrastructure (software, models, services, etc.) for supporting collaborative work of human operators in emergency/disaster scenarios. In such scenarios, different teams, belonging to different organizations, need to collaborate each other to reach a common goal; each team member is equipped with handheld devices (PDAs) and communication technologies, and should carry on specific tasks. In such a way we can consider the whole team as carrying on a process (macro-process), and the different teams (of the different organizations) collaborate through the interleaving" of all the different processes. Each team is supported by some back-end centre, and the different centres need to cooperate at an inter-organizational level to reach an effective coordination among teams. Each team is referred to one specific organization, which is the only agent in charge of controlling its teams, and the teams thus form a virtual organization.The project will investigate a 2-level framework for such scenarios: a back-end peer-to-peer community, providing advanced services requiring high computational power, data & knowledge & content integration, and a set of front-end peer-to-peer communities, that provide services to human workers, mainly by adaptively enacting processes on mobile ad-hoc networks.The consortium consists of a complementary set of top-level scientific partners (i.e., UOR, TOR VERGATA, TUW, SALZBURG RESEARCH), a world-leading industrial company (i.e., IBM ITALIA S.P.A.), very focused SMEs (i.e., MOVIQUITY, SOFTWARE602) and a user partner capable to take up WORKPAD results (i.e., Regione Calabria - Settore Protezione Civile [Homeland Security Department], PCRC). Such consortium composition guarantees
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Modern methods in mathematics' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Proposal for support of 36 conferences with support for 576 eligible event participants in 2007 at the Mathematisches Forschungsinstitut Oberwolfach (MFO), on Modern Methods in Mathematics" within the programme "Marie Curie Conferences and Training Courses/Series of Events". The MFO is one of the leading mathematical research centres worldwide, which organises weekly high-level international conferences in all fields of mathematics and its applications.The aim of these conferences is to present the most recent developments and to discuss further research projects. Many important developments in mathematics originated from one of these workshops, and almost all relevant mathematical results were presented here and discussed by the leading experts."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'BIOMEDICAL EQUIPMENT ASSESSMENT AND MANAGEMENT' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

BEAM II pursues EU research in telematics for biomedical professionals involved in the distribution, use and follow-up of medical devices. Its main aims are to extend the already developed application, by creating, validating, and commissioning BEAM services over the European information highway, and to prepare BEAM tools for the market. The project will bring developments into the area of field applications, while creating generic applications readily adaptable to individual hospital requirements. It will provide the platform for a new approach to biomedical technology management, based on compliance with EU regulations and standards.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Research reactor dr3 at risoe national laboratory'.

assistant: **Concept**

Description:The neutron scattering facilities at RIS provide intense beams of cold neutrons for research in three main areas: small angle scattering and reflectivity; materials and structural science; and spectroscopy. Under EC sponsored programmes approximately 20% of the total beam, time (equivalent to 60 beam weeks) is made available to outside users. In addition, there is one thermal neutron instrument for powder diffraction and texture measurements.Ancillary equipment available to the users includes: displexes, helium flow cryostats, cryomagnets (9T vertical, 5T vertical, 2T horizontal), dilution fridge, furnaces, sheer cells, and strain rigs. Within the last five years 3 of the instruments (TAS3, TAS6/RITA, TAS8) have undergone major upgrades, and this year an upgrade to TAS7 will be completed. Presently we are in a process of reviewing future upgrades. These will probably include the development of a dedicated reflectometer, and the construction of anew general-purpose materials diffractometer on the thermal source.Application:There are three application rounds per year (April 1, August 1, December 1) when potential Users are invited to submit proposals. The proposals are divided by specialisation, and then sent to the appropriate referee. All referees, however, are sent all proposals. The referees are asked to grade the proposals, and to return their grades with any additional comments.Proposals are graded under five categories:A. Very good, and will be given priority in the beam allocation;B. Good, and will be given time if the demand is not too high;C. Sound, but will only be given time if available;D. Not a suitable experiment for the facility;E. For new Users with little or no experience who require hands-on training.A beam allocation meeting is then held wi