RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Computer modelling of abnormal cardiac repolarisation, including comparison with real clinical data' (1994-1998).

assistant: **Innovation**

Research objectives and content An electrocardiogram is usually recorded from all patients with heart problems Electrical recovery of the heart after each beat is essential, and can be seen clearly on the electrocardiogram Differences in electrical recovery time as seen from different electrodes appear to provide a useful indicator of underlying heart disease, but as yet cardiologists do not know enough about this process to make clinical use of the information This project will show how the electrocardiogram can be interpreted to give cardiologists useful clinical data from different regions of the heart. This research proposal will investigate and quantify how well mathematical models of cardiac repolarisation account for the for a range of T wave abnormalities - including bundle branch block, T wave inversion in infarction, ST depression and elevation in all 12 leads of simultaneously recorded 12-lead electrocardiograms (ECGs). The simplest models will be studied with normal ECGs, and the models extended to take account of varying propagation patterns and more complex pathways. Training content (objective, benefit and expected impact) The objective is to acquire knowledge both in the engineering field, particularly in mathematical modelling of biological systems, biomedical data acquisition and processing, and in the medical field, on the cardiovascular system the interaction with patients, and with the experts of the medical field Moreover, I will have a unique opportunity to learn to 'fill the gap' between the world of engineering sciences and that of medical sciences More and more collaboration is now required between these two worlds in order to go beyond the limits of both sciences. I hope I will be able to come back to Naples, in Campania (Italy), my birth plac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Spectral rigidity and integrability for billiards and geodesic flows' (SPERIG) under Horizon 2020.

assistant: **Objectives**

In 1911, Hermann Weyl proved the remarkable asymptotic formula describing distribution of (large) eigenvalues of the Dirichlet Laplacian in a bounded domain Ω ⊂ RdN (λ) = (2π)−d ωd Vol(Ω) λd/2(1 + o(1))as λ → +∞. where N (λ) is the number of eigenvalues of the Laplacian spectrum, which are less than λ, ωd is a volume of the unit ball in Rd, Vol(Ω)  is the volume of Ω,  and the Laplace spectrum of a domain Ω is defined as the set of positive real numbers λ (with multiplicities) that satisfy the eigenvalue problem in Ω with Dirichlet boundary conditions. This result motivated the title of a famous paper by M. Kac “Can you hear the shape of a drum?”. The question is: can the shape of a bounded domain O C Rd be determined by the Laplace spectrum?  Two  domains are  called isospectral if they have the same eigenvalues. Consider the space of domains with a smooth boundary. The existence of isospectral non-isometric domains is a well-known open question.The first goal of the project is to prove the local spectral rigidity for convex planar domains, i.e. for a smooth convex planar domain Ω the Laplace spectrum determines Ω locally.  There are no nearby isospectral non-isometric domains with smooth boundary.  All of the  these questions can also be posed for Riemannian manifolds. The second goal is to prove the local rigidity for Riemannian manifolds with Anosov geodesic flows.The third goal is to prove local rigidity for integrable systems: geodesic flows on  tori (resp. convex planar billiards). The goal is to prove that an integrable metric close to a Liouville metric is Liouville. The second type is billiards inside smooth planar domains integrable near the boundary. We shall prove that domains with integrable billiards belong to a finite-dimensional manifold.The focal goal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'GreenApes Sustainability Software Service: Employee Engagement for Eco-innovation' in the context of a Horizon 2020 call.

assistant: **Objectives**

The ECO-ENGAGE solution will support companies to achieve Corporate Social Responsibility (CSR) and sustainability targets (mainly energy and resource efficiency), through a novel composition of social networking and gamification solution, capable of stimulating employees’ eco-friendly activities.The project implementation will impact on the optimization of resources, the reduction of the overall environmental impact or organizations and consequent mitigation of climate change. The strength of ECO-ENGAGE solution relies on:  1) Employees-centric sustainability platform, in which employees do not perceive sustainability as a corporate prescription but rather as a contribution to a larger, global sustainability project; 2) Team achievement approach through incentives for the adoption of sustainable behaviors, tangible rewards, gamification techniques for engagement, the creation of a social sustainability profile; 3) Appealing user-friendly interface that turns natural human curiosity into a valuable learning experience. Overall, the innovative ECO-ENGAGE project will benefit: 1) Targeted clients. With the implementation of the greenApes Employee Engagement Platform (EEP), large organizations can obtain a ROI of up to 50% already in the first year . Considering the huge economic, commercial and Environmental advantage Enel Green Power already signed an agreement to adopt the solution once in the market (5000 employees will be involved).2) The Proponent. With an estimated ROI of 88% in 3 years the project has the potential to boost company's growth.The current technology readiness level of ECO-ENGAGE project is TRL 7, and it aims at reaching TRL 8-9 by Phase 3. The financing from Phase 1 will provide ECO-ENGAGE insights on the market and on tools for marketing and structur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'In vivo biology of the mononuclear phagocyte system. A molecular & functional approach' in the context of a Seventh Framework call.

assistant: **Objectives**

Leucocytes are hemopoietic cells involved in tissue homeostasis, inflammation, and the defence against infection. Recent efforts have focused on the  innate immune system , responsible for the early defence against pathogens, at the cost of tissue inflammation and inflammatory disease. New tools and experimental strategies have allowed investigation of an essential component of the innate immune system: cells referred to as the  mononuclear phagocyte system  (MPS), which includes blood monocytes, tissue macrophages, and dendritic cells.In a project supported by an Euryi award in France, we identified bone marrow progenitors for the MPS (Fogg et al., Science 2006), and a surprising exception to this rule: the existence of non-bone marrow precursors for tissue-resident cells (Chorro et al., J. Exp. Med 2009 in press), and in vivo functions of blood monocytes using intravital microscopy (Auffray et al., Science 2007). In 2008 I moved to London to start a new laboratory and benefit from a multidisciplinary environment, but I was not allowed to transfer my EURyi funding.This new project build on our early discoveries, and aims to bring to the next stage the molecular analysis of monocyte/macrophage functions in an intact animal. Toward this aim we will therefore use a direct in vivo approach based on innovative mouse models and cutting edge microscopy techniques, to i) characterise the molecular control of homeostasis of a subset of  resident  cells  of the MPS, the Langerhans cells, which are independent from the bone marrow, under steady state and inflammatory conditions, and investigate whether this model apply to other  resident cells . We will also characterise the ii) functional outcomes and iii) the molecular mechanisms of tissue surveillance by blood monocytes during
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Next generation automated sorting, tracing and closed-loop recycling technologies for non-rewearable textiles' under Horizon Europe.

assistant: **Concept**

AUTOLOOP’s primary ambition is to become a transformative force in the European Textile and Clothing Industry, supporting its transition towards a sustainable circular economy by effectively addressing its current critical challenges. Its overall objective is to develop cutting-edge and scalable technology to build the next generation system for intelligent automated sorting and advanced chemical recycling of non-rewearable textiles (NRT), science-based additive tracing and digitalisation of the textile value chain. Technology development is at the core of the project bringing artificial intelligence powered automated sorting, advanced chemical recycling and additive tracing technologies from their current Technology Readiness Level (TRL) 3 to TRL 5. The textile Data Hub will collect and process data from each recycling step in a Digital Product Passport-compatible format, facilitating transparency, data accessibility and interoperability. The AUTOLOOP chemical recycling technologies are pollutant-resistant and can extract pollutants from the NRT feedstock to deliver a clean and safe fibre product stream through the value chain to the customers. Preliminary modelling suggests that 96% of the net input post-consumer textile can be re-used or recycled by the AUTOLOOP system. According preliminary estimations, a total of 33 AUTOLOOP systems with individual capacity of 11.25 t/h post-consumer textile input can process the total current available NRT potential (1.24 Mt/a) producing: about i) 350,000 t/a of pure NRT fractions, ii) 372,000 t/a Lyocell-fibres, iii) 300,000 t/a virgin quality polyester fibres, iv) 114,000 t/a polyamide and other synthetic fibres. A preliminary estimate suggests that by processing the mentioned NRT potential, the resource savings account to appro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Integrated and functional Lab-on-Chip'.

assistant: **Objectives**

The objective of this project is to create Lab-on-chip devices that allow sensitive analyte detection as well being highly integrated and have high functionality. The project will develop lab-on-chip platform technologies for fluidic manipulations and analyte detection and develop specific Lab-on-Chip (LOC) applications. Integrated and easy to use fluidic manipulations within LOC devices will be achieved through firstly use of electro-osmotic flow (EOF) and through on-chip pressure system and passive valves. We will also demonstrate that LOC devices can be designed to perform sophisticated fluidic operations over a large element array of microchambers.  large scale valving integration approach will be used to achieve discrete fluidic operation for each microchamber element within the array. A convenient LOC macro-micro world interface for fluidic, mechanical and electrical elements will be developed as well as sensitive optical and electrochemical strategies for detection. Novel optical detection approach which involves increasing the pathlength of the radiation within the microfluidic channel will be further advanced for highly sensitive optical detection within LOC devices. Sensitive electrochemical transduction will also be developed. The developed LOC platform technologies will be incorporated as part of a disposable cartridge to be inserted within a handheld reader device for bioanalysis. Specifically, we will develop systems for (i) biochemical discharges of airborne enzymes, (ii) continuously monitored bioreactor array and (iii) natural toxic monitor for potatoes. The project will bring together a wide range of leading expertise from the public sector and research organisations to create LOC devices that are reproducible, have a small footprint, are easy to use a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Identification of new targets against hepatitis c virus - a genomic approach' (1998-2002).

assistant: **Innovation**

By the use of DNA microarray technique we want to identify human genes, which are important for hepatitis C virus (HCV) replication, pathogenesis, or protection against viral infections. Identification of those genes will represent new targets for the development of new therapeutic and preventive strategies against HCV infections.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Carbon sequestration in BLUe EcoSystems' (C-BLUES) under Horizon Europe.

assistant: **Objectives**

C-BLUES will significantly advance knowledge and understanding of blue carbon ecosystems (BCEs) seagrasses, tidal marshes, mangroves, macroalgae, and macroalgae mariculture aiming to achieve three overarching objectives: 1) develop new scientific knowledge within BCEs to reduce scientific uncertainty and improve reporting of blue carbon under the United Nations Framework Convention on Climate Change (UNFCCC), 2) provide input to a possible revision of the 2013 IPCC Wetlands Supplement to increase inclusion of coastal wetlands in national greenhouse gas (GHG) inventories and reporting, 3) raise awareness and promote the role of blue carbon for delivering global climate policy commitments in collaboration with Chinese and other international partners. C-BLUES will perform the following: produce spatial maps, methodological best practices and standard operating procedures; enable more robust and reliable quantification of carbon emissions and sequestration; model sequestration capacity and upscale regional and global GHG budgets; assess carbon stock changes, GHG emissions and removals related to different management interventions and human activities; review legal and institutional frameworks governing BCEs; and assess the drivers and barriers for integrating coastal wetlands into national reporting mechanisms under the UNFCCC. C-BLUES will target the following Mission Ocean Lighthouse Areas (LA): LA Atlantic/Arctic, LA Baltic and North Sea, and LA Mediterranean Sea. The Black Sea, Dutch Antilles, and through collaboration with China, the Southern China coast will also be covered. C-BLUES will engage with the scientific community, climate and coastal policy makers and the wider civil society to disseminate the knowledge generated, raise awareness of BCEs and build capacity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Hydrostatic extrusion process for efficient production of magnesium structural components' to be submitted under Fifth Framework.

assistant: **Abstract**

Aim of the project is to improve magnesium manufacturing technology for structural components by development of a direct hot hydrostatic extrusion process and tailoring alloys and billet preparation in order to improve extrudability and meet functional requirements for lightweight automotive, aerospace, railway rolling stock and bicycle applications. Research concerns hydrostatic extrusion processing, alloy development and casting, magnesium processing technologies and the development and testing of demonstrator components. A five to ten-fold productivity increase is expected for magnesium extrusions, which corresponds with a 50 % lowering of the manufacturing costs. The targeted weight reductions for components such as side impact bars, window cross members and bicycle fore forks are 30% and 80% compared to aluroinium and steel counterparts, enabling a breakthrough for magnesium extrusions for transport applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Dissecting mechanisms of epigenetic reprogramming driving metastatic transition using cancer patient-derived organoids'.

assistant: **Concept**

Cancer development is a convoluted biological process that reshapes cellular identity. Genetic mutations are crucial in driving such process, yet fail to fully explain metastatic transition—a critical step in cancer evolution. For this reason, reprogramming driven by non-mutational epigenetic changes is increasingly recognized as a potential mechanism by which cancer cells acquire metastatic properties. Despite the genetic heterogeneity, specific transcriptional programs are activated to promote the acquisition of such properties. Therefore, understanding the role of changes at the chromatin level in facilitating metastatic transitions becomes crucial.To address this, I will use patient-derived organoids (PDOs) generated from primary colon cancer and various metastatic sites. PDOs are an optimal model system available in the hosting laboratory, providing a platform for investigation and subsequent functional validation. The project’s first goal is to profile changes in histone modifications and in the enhancer interactome, in primary and metastasis PDOs. This will identify chromatin states transitions and cis-regulatory elements with a key relevance in metastatic progression and maintenance (Aim 1). Transcription factors (TFs) with potential regulatory roles in these processes will be identified by integrating chromatin accessibility data and performing footprinting analysis (Aim 2). Functional validation of candidate TFs will be conducted using CRISPR perturbations, combined with single-cell multi-omic readout and in-vitro assays to assess PDOs' fitness and invasiveness potential (Aim 3). Altogether, in this project we will employ a comprehensive approach to investigate the molecular mechanisms underlying the activation of pro-metastatic gene regulatory networks, provi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'A unified framework for Perceptual Inference in Sensory cortices'.

assistant: **Innovation**

The neural mechanisms that underlie perceptual inference in cortex are a matter of intense research. Neural models implementing Bayesian models have proved useful to uncover neural computations in a variety of paradigms. Still no existing neurocomputational model provides a general framework for understanding perception in naturalistic conditions. Indeed these models suffer from three shortcomings: i) they cannot perform accurate inference in naturalistic environments where numerous objects interact in complex fashion; ii) they cannot simultaneously represent likelihood estimates over the presence of several objects in the same graphical model; iii) they cannot deal with correlated sensory evidence, though such correlations are ubiquitous in sensory systems.We propose a new unifying model of perception called Constrained Entropy Maximization Network (CEMNet) that provides a theoretical framework for inference in complex naturalistic environments. CEMNet stores an internal model of the environment by representing regularities across stochastic variables as constraints; those constraints shape the response of the network. The aim of the project is to develop the computational model of CEMNet and test it empirically. We will first study how CEMNet can be implemented in a realistic neural network. Second, we will simulate the network and show that, unlike existing neural models, CEMNet can deal with the difficulties of inference in complex environments. Third, a behavioral experiment will monitor how human subjects integrate correlated sensory evidence. Last, we will probe the ability of human subjects to simultaneously maintain likelihood estimates over multiple interacting variables in an audiovisual motion integration paradigm. We will record neural signals in MagnetoEnc