RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'COLOStage : A new prognosis test for the prediction of metastasis in Colorectal Cancer and Hepatocellular Carcinoma' to be submitted under Horizon 2020.

assistant: **Abstract**

ColoStage is a new prognostic test, based on a novel gene expression signature, able to predict robustly the risk of disease relapse after therapeutic intervention in colorectal cancer (CRC) and potentially in hepatocellular carcinoma (HCC).  We have previously demonstrated that CRC recurrence and metastasis strictly depend on high TGF-beta signaling (Calon et al., 2012). ColoStage is a gene expression signature that reflects the TGF-beta status of the primary tumor. Therefore, the expression of the ColoStage  geneset is tightly linked to the formation of recurrent CRC after therapeutic intervention in CRC. Importantly, Colostage may also aid in the selection of patients for clinical trials who will likely benefit from newly developed drugs that target the TGF-beta signaling pathway in CRC, and possibly in other types of tumors, HCC among others, (potential use as a companion diagnostic test; i.e. Companion Dx). This proposal aims to develop the Colostage Test for competitive use in the clinical setting. This includes validation of the predictive power of the Colostage Test in an independent cohort of patient samples. Worldwide, CRC and HCC are the 3rd and 6th most commonly diagnosed cancers, with nearly 1.4 million and 800.000 new cases diagnosed in 2012 respectively. The primary treatment for CRC and HCC is surgical resection of the tumor. Prescription of chemotherapy depends on the stage of the disease at the time of diagnosis, yet current staging systems have a limited power to predict disease relapse which is usually associated with poor prognosis. Thus, an accurate method for selecting treatment based on aggressiveness and recurrence probability of the tumor such as Colostage will allow to allocate resources in a cost-effectively way and to make existing drug ther
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Reconstructing Mediterranean-Atlantic exchange during the Miocene'.

assistant: **Objectives**

MEDGATE combines the expertise of 29 geoscientists from both the oil industry and academia in the training of 10 researchers.  It aims to equip these researchers for successful careers in either sector through interdisciplinary projects focussing on an intriguing problem which has implications for both environmental change and hydrocarbon exploration.  The research aim of MEDGATE is to reconstruct the evolution of the marine corridors that linked the Atlantic and Mediterranean prior to the formation of the Gibraltar Straits about five million years ago. Closure of these gateways led to catastrophic changes in Mediterranean sea-level and salinity and to the formation of hydrocarbon accummulations.  Despite decades of research, the exact timing of closure, the geometry of the corridors and the pattern of exchange through them, remains uncertain. Previous work has been conducted mainly using single research methodologies. The MEDGATE project provides a unique opportunity to undertake a suite of ten interdisciplinary projects that integrate state-of-the-art technologies, surface and subsurface datasets and expertise supplied by both academic and industrial partners. These new data will clarify the environmental impact of gateway exchange and help assess the petroleum potential of the region.  MEDGATE network-training programme will support the skill requirements of each project and foster interdisciplinary collaboration.  It also emphasises training in advanced field geology and biostratigraphy, to address the declining skill levels in geoscience graduates reported by MEDGATE’s industrial partners. All eleven participating institutions will contribute substantially to network-wide technical and complementary skills training and each institution has committed to seconding on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ultrasensitive Luminescence-based Yeast Sensors for Specific Early Cancer Sensing' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

ULYSSES is a pioneering project aimed at developing a non-invasive, portable, and user-friendly biosensor for the early detection of breast and prostate cancers through urine analysis. Its core vision is to identify cancer-related volatile organic compounds (VOCs) and develop a biotechnological device for their detection in urine. The innovation lies in mimicking the extraordinary olfactory system of the nematode Caenorhabditis elegans, which can distinguish cancerous from healthy urine with over 90% accuracy. This ability is mediated by a large repertoire of olfactory receptors (ORs) expressed on specialized sensory neurons. ULYSSES replicates this sensing capacity in a synthetic biology framework by introducing selected C. elegans ORs into engineered yeast (Saccharomyces cerevisiae). These ORs are functionally coupled to a bioluminescence resonance energy transfer (BRET)-based biosensing construct. Upon binding cancer-associated VOCs, conformational changes in the ORs trigger measurable BRET signal shifts, serving as indicators of cancer-specific profiles with nanomolar sensitivity. In parallel, urine VOCs will be analysed via gas chromatography–mass spectrometry (GC-MS). Machine learning will be applied to the spectral data to identify key compounds that differentiate cancer from healthy samples and link them to specific OR activation profiles. Engineered yeast biosensors, each with a distinct OR-BRET construct, will be arrayed on a disposable device. Upon urine exposure, BRET signal changes will be recorded and interpreted via an AI algorithm trained on activation heatmaps. This enables the identification of cancer-related patterns with high sensitivity and specificity. Feasibility is ensured by the convergence of expertise within a strongly interdisciplinary consor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'COLFIN: Colonial Financial Infrastructures' under Horizon Europe.

assistant: **Concept**

COLFIN develops a new approach to understanding and responding to the colonial durabilities in modern financial infrastructures. The starting point is that the relation between finance and colonialism is infrastructural, not purely related to individual families or companies. Financial innovation co-evolved with colonial expansion and vice versa. The longer time horizons, transnational payments and novel uncertainties of colonial expansion are at the heart of modern financial innovation. Academic literatures acknowledge this but largely write colonial violence out of the history of finance. The aim of COLFIN is to understand and analyse how the experimental beginnings and development of financial instruments were shaped by and through colonial exploitation and appropriation. The novel approach is to focus on financial infrastructures, understood as socio-technical and historically durable ways of organizing political-economic life. The key question of COLFIN is: How are modern financial infrastructures, including credit, currency and collateral, shaped by and through colonial practices of exploitation and appropriation? COLFIN focuses on four infrastructural elements: (1) material technologies; (2) circulation; (3) adverse inclusion; (4) practices of temporality. COLFIN breaks new ground because (1) it offers systemic analysis of a largely neglected part of the history of political economy and finance; (2) it shows how present financial infrastructures indirectly entail refashioned colonial practices and routes. It is urgent because it reconnects the account of financial innovation to the history of colonial exploitation, to generate new avenues of accountability in the present. It is feasible because of the availability of newly digitized archives of early modern publi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'GN4-2 Research and Education Networking - GÉANT' (GN4-2) under Horizon 2020.

assistant: **Objectives**

GN4-2 is the proposed project for the second Specific Grant Agreement under the 68-month Framework Partnership Agreement (FPA) established between the GÉANT Consortium and the European Commission in April 2015.This second phase of implementing the FPA will raise European research to the next level by promoting scientific excellence, access and re-use of research data. It will also drive European-wide cost efficiencies in scientific infrastructure by promoting interoperability with other e-infrastructures on an unprecedented scale.The FPA objective for the GÉANT Partnership is to contribute to effective European research by making Europe the best-connected region in the world. GÉANT must offer European researchers the network, communications facilities and application access that ensure the digital continuum necessary to conduct world-class research in collaboration with their peers, regardless of geographical location.GÉANT will maintain the operational excellence of the established GÉANT services, while achieving economies on the costs of the backbone network. The reliable, secure and state-of-the-art network services offered to researchers and other network users across Europe will remain exceptional. Massive data-transfer capacities required by extreme-scale instruments and by the penetration of big data in many areas of science will be prototyped with due consideration to the specific security and deployment challenges. Trust and identity is also prioritised with the introduction of a scalable operational model and with user requirements addressed in close concertation with the AARC and proposed AARC2 projects.GN4-2 developments are also guided by the vision of a future where a set of coherent and integrated European e-infrastructure services will offer convenient,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MULTIFUNCTIONAL MICROFLUIDIC PATCH FOR INFECTIOUS DISEASES DIAGNOSIS' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

In vitro diagnostic (IVD) technologies have revolutionized healthcare, yet remain confined to the laboratories. As witnessed during the COVID-19 pandemic, this traditional centralized approach was not sufficient to prevent and manage viral outbreak because it massively failed to deliver quick and cost-effective diagnosis. The ongoing pandemic further emphasizes the growing need to urgently bring lab-quality diagnosis to the hands of end users (i.e. point-of-care, POC). Despite high expectations from Lab-on-Chip technologies, they failed so far to disrupt the IVD market due to their complexity of integration/operation, high cost, off-chip sample preparation, poor scalability, to mention only a few. The FORTIFIEDx consortium aims to revolutionize the POC IVD field by making use of novel multifunctional biocompatible polymers and their (micro)structuring with mass fabrication technology to develop for the first time a true sample-to-result POC test. We will develop a FORTIFIEDx microfluidic-based patch capable of both biofluids (self-)sampling via hollow microneedles and immediate analysis of this sample on the very same patch in a completely self-powered manner. Two unmet clinical needs, posing epidemic/pandemic treats to both the developed and developing world, are selected: (1) sexually transmitted diseases, in particular simultaneous diagnosis of HIV and Syphilis, to enable timely diagnosis of patients not always able to reach centralized settings due to stigma or financial difficulties and (2) viral haemorrhagic fever, in particular Ebola and Lassa viruses, to battle their highly contagious and deadly outbreaks. To tackle this challenging aim, the interdisciplinary and experienced FORTIFIEDx consortium (2 universities, 5 research institutes and 2 SMEs from 6 countries
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Development and evaluation of mineralized silk based composites for orthopaedic applications.'.

assistant: **Objectives**

The consortium seeks to develop a highly novel bone substitute material (BSM) from mineralized silk composites for use in medical procedures requiring bone tissue replacement. Spinox have developed Spidrex, a novel silk-silk composite based on a fibre and matrix generated from spider silk analogues. Spidrex is biocompatible, bio-absorbable and has excellent mechanical properties and cell adhesiveness. Pilot studies at Bristol have shown it is rapidly and heavily mineralised by the component of natural bone, hydroxyapatite. Mineralised Spidrex will be developed into a BSM by incorporating osteoinductive factors in the silk matrix and biochemical tailoring both fibre and matrix. Progentix will develop non-foetal stem cell technology with which to seed the BSM. 3H Biomedical and U Kon InPuT will test human cell reaction to BSM in vitro. This will reduce the need for animal trials and allow material modification early in the design process.Soton will optimise bone formation in the BSM in vitro. A cellularised, load bearing, resorbable BSM is unprecedented and will provide entry to a market estimated at 2.5 billion euros. It will be particularly advantageous for the treatment of fractures resulting from osteoporosis and bone lesions in cancer patients. The consortium comprises 3 highly innovative, research based SMEs from 3 member states whose competitiveness will be enhanced by access to this market and by collaboration with the consortium's 5 leading RTDs. Individually, each SME does not have the capability to pursue a project of the above magnitude. Tissue engineering, adult stem cell research and implantable biomaterials have been flagged as future growth markets, keenly pursued in the U.S. and Asia. Developing know-how in these areas, and subsequent dissemination of res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of standards for testing the cleanability of textile articles in commercial wet cleaning and hydrocarbon solvent cleaning processes' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Background: With the banning of R113 (CFC) production and the Volatile Organic Compounds (VOC) Directive, the European dry cleaning industry has already been reduced in capacity. New technologies of wet cleaning and hydrocarbon solvents are needed to re-establish the cleaning capacity, which the textile industry and the public require. This study will provide the basis for drafting commercial machine based test methods for assessing the cleanability of textile articles in the new processes and will make possible appropriate care labelling. Objectives The overall objectives of this project are to present draft standard test methods for wet cleaning and hydrocarbon cleaning of textiles to CEN/TC248. In particular test methods must take into account of the need to have a faster-than-real time predictable test for wet cleaning to allow for the lower volatility of hydrocarbon solvents in drying.Work programme Wet cleaning involves treating the textile with reduced mechanical action and chemicals to both protect and enhance cleaning efficiency. An accelerated, predictive test method, will be developed which may be carried out in a wide variety of commercially available systems. This test method, which will be validated in an inter- comparison trial and will be conversed to a draft standard. The higher flash point and lower volatility of hydrocarbon solvents may give rise to problems in the drying of sensitive textiles. Alternative techniques for aiding drying include high extraction forces, longer drying times and higher drying temperatures. These variables will be investigated in order to develop a test method, which will be validated in an inter-comparison trial, prior to conversion to a draft standard.State of progress: The project has recently started.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ERA-Chair in Science and Innovation Policy and Studies', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The ERA Chair in Science and Innovation Policy & Studies (SInnoPSis) aims to attract a high calibre academic in order to bring together excellent academics from the linked scientific departments and consolidate all related research activities at the University of Cyprus (UCY). This vision will be realised by attracting and maintaining an international calibre professor accompanied by a group of exceptional scientists in the field of Science and Innovation Policy and Studies (SIPS), coupled with the establishment of a multidisciplinary research unit which will allow optimal exploitation of the existing research capacity and infrastructures of UCY and facilitate the gradual upgrade of the research activities in the field. The principal thematic focus will be on the SIPS field, including all connected fields with emphasis on Economics & Management and secondarily Social and Political Sciences, Philosophy and Information Technology. The Chair will be the Research Director of the foreseen SIPS research unit having full autonomy in carrying out a research programme formulated by him/her a few months after the recruitment. This will enable the ERA-Chair team alongside scientists from linked departments of UCY whose expertise ranges in these fields to produce cutting-edge multidisciplinary research output and innovative educational and training programmes. The Chair will also create significant impact in Cyprus, by contributing with the expertise and research results of her/his group in advocating the Chief Scientist, the National Council of Research and Innovation and the Research Promotion Foundation in significant issues related to SIPS and the implementation of research and innovation policies in Cyprus. UCY will make all necessary arrangements and institutional changes nee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Real-time bradykinin monitoring during acute pancreatitis using on-line dialysis combined with liquid chromatography-immunochemical detection'.

assistant: **Objectives**

Research objectives and content Objectives: Real-time" monitoring of bradykinin during acute pancreatitis Content: Development of an on-line analysis method consisting of dialysis, liquid chromatography and immunochemical detection Training content (objective, benefit and expected impact) Application of novel analytical tools in a clinical situation Links with industry / industrial relevance (22) No "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Shaping European Research Leaders for Marine Sustainability'.

assistant: **Innovation**

SEAS will provide exceptional inter- and transdisciplinary research and training opportunities, supported by a dedicated team supervision and inter-sectoral mentoring scheme for 37 ERs in the area of marine sustainability, a strategic focus of the beneficiary University of Bergen, Norway. The SEAS programme promotes excellent, transdisciplinary research at the marine science-society-policy nexus. The programme will attract excellent researchers (for both incoming and outgoing mobility) through an inclusive, transparent, merit-based, and structured recruitment process. The ERs will acquire novel insight and skills in high-calibre research projects set within a transdisciplinary context, with the opportunity to transfer knowledge and skills between disciplines, organisations and sectors, and to harness entrepreneurial mindsets for innovation. SEAS will offer academic freedom, equal opportunities, personal career support, structured skill-based training, a regional ecosystem of marine actors, and high-quality working conditions. The ERs will be employed in postdoctoral researcher positions at UiB, with three-year contracts and full social coverage. Through SEAS, the ERs will gain unprecedented possibilities to diversify their marine career options within Norway, the European Research Area (ERA) and internationally.


**Keywords:** inter- and transdisciplinarity, marine sustainability, science-society-policy nexus