RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Diagnostic Ecotoxicology: cell-based methodology to develop markers for early, sublethal effects assessment' (1994-1998).

assistant: **Concept**

The proposed project aims at a rational development of scientifically based ecotoxicological effects assessment methodology as required for refinement of water quality objectives in EC countries. The combined utilization of novel cell culture technology with conventional whole animal experiments represents an innovative approach in establishing markers for the early diagnosis of exposure and sublethal effect. The proposal can achieve this task because it assembles a unique group of European experts in cell culture technology and whole animal physiology. The proposed programme has been targetted at freshwater organisms, particularly fish and amphibia. A comparison between these evolutionary related animal groups with clearly different life history will illustrate fundamental processes of toxicant action as well as the value of cellular markers for diagnosis of pollutant exposure and effect. The design of the work programme integrates a cell-to-organism approach - establishing diagnostic markers in studies with isolated cells and asking whether these markers still work in the intact animal - with an organism-to-cell approach - using animals exposed to low levels of toxicants and asking whether the diagnostic markers are expressed in their cells: - Mechanisms and characteristics of chemical action will be studied in isolated cells (alternative models) that are targets of toxicant uptake, metabolism or effect (skin, gills, gut, liver, muscle, spermatogonia, leucocytes, macrophages). - The ecotoxicological implications of accumulation and effect of chemicals will be assessed by (a) differentiation between protective (tolerance) and pathologic (disease) processess, and by (b) validating the in vitro findings in in vivo studies, usi both field sampling (agricultural areas, Elb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cryogenic wide-Area Light Detectors  with Excellent Resolution' under Seventh Framework.

assistant: **Concept**

In the comprehension of fundamental laws of nature, particle physics is now facing two important questions:1) What is the nature of the neutrino, is it a standard (Dirac) particle or a Majorana particle? The nature of the neutrino plays a crucial role in the global framework of particle interactions and in cosmology. The only practicable way to answer this question is to search for a nuclear process called ""neutrinoless double beta decay"" (0nuDBD).2) What is the so called ""dark matter"" made of? Astrophysical observations suggest that the largest part of the mass of the Universe is composed by a form of matter other than atoms and known matter constituents. We still do not know what dark matter is made of because its rate of interaction with ordinary matter is really low, thus making the direct experimental detection extremely difficult.Both 0nuDBD and dark matter interactions are rare processes and can be detected using the same experimental technique. Bolometers are promising devices and their combination with light detectors provides the identification of interacting particles, a powerful tool to reduce the background.  The goal of CALDER is to realize a new type of light detectors to improve the upcoming generation of bolometric experiments. The detectors will be designed to feature unprecedented energy resolution and reliability, to ensure an almost complete particle identification. In case of success, CUORE, a 0nuDBD experiment in construction, would gain in sensitivity by up to a factor 6. LUCIFER, a 0nuDBD experiment already implementing the light detection, could be sensitive also to dark matter interactions, thus increasing its research potential. The light detectors will be based on Kinetic Inductance Detectors (KIDs), a new technology that proved its pote
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'FORTE/PSTV International Conference on Formal Methods for Distributed Systems and Communication Protocols-Pisa, October 2000' in the context of a Fifth Framework call.

assistant: **Objectives**

FORTE/PSTV 2000 is a single, articulated event consisting of a Tutorial day followed by a three-day Conference; both focus on Formal Methods for the development (requirements capture, specification, verification, performance analysis, implementation, testing) of distributed systems and communication protocols. A multidisciplinary Satellite Workshop, in parallel with the Tutorials, is meant to explore applications of Formal Methods to a variety of other fields. Several approaches are considered, based on Process Algebras (CCS, pi-calculus, LOTOS, stochastic), Extended Automata, (SDL, Estelle, timed automata, statecharts, reactive), Set Theory (B, Z, VDM), Petri Nets, Logics (temporal, TLA), Abstract Data Types (OBJ, Larch) and other standard notations (MSCs, ASN.l, TTCN, etc). FORTE/PSTV has been and still is the only international conference to provide such a wide coverage of theory and application of Formal Methods, perhaps with the exception of FM'99 (World Congress on Formal Methods for Computing Systems - Toulouse). A demo-room shall be available during the conference for industrial and academic tool demonstrations. The objective of the conference project is to continue providing an internationally recognized forum for presentation of the state of the art in theory, application, tools and industrialization of Formal Methods, and to provide a comprehensive orientation for young researchers and newcomers.The topic of Formal Methods has quite strong European roots. As the attention to this topic increases outside Europe, and, most notably, in the United States, this first Italian edition of the Conference will once more represent a European contribution to an area of Computer Science where Europe can still claim some leadership.ftp://ftp.cordis.lu/pub/improving/docs/HP
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Thermolytic Recovery of Cu and Precious Metals from Electronic Circuit Boards and Cu -'laminas', in a Fluidized Bed Reactor' (1994-1998).

assistant: **Concept**

The principle objective of this project is the development of a technology, which will be friendly to the environment and capable for the efficient retrieval of copper (Cu) and other precious metals (Au, Ag, Pd). These metals are embedded in a variety of scrap composite materials, such as composite copper laminas and old or used Printed Circuit Boards (PCBs). The proposed recycling technology is based upon thermo physical principles, focused on the separation of organic mater from copper or from the embedded precious metals and from . The separation and the recovery of copper can be achieved via a thermolytic process which is applied on pre processed pieces of scrap, utilising a multistage fluidized bed reactor technology. In case of using as raw material laminas the process retreives small pieces of copper (Cu 99,9%). In case of recycling PCBs the process retrieves agglomerates consisting of copper and other precious metals. In the first case the recycled product (copper) is fed directly to the market, in the last case agglomerate mater, should be post processed (electrochemicaly) in order to separate the copper from the other precious metals. The effluent gases will be treated by CaCO3 in order to absorb the produced Cl2 (5 10% w.w.) during the multistage fluidisation process. In case of excess of effluent gases, they will be further treated in order to avoid any undesired environmental effects and to achieve the overall process compliance with the EEC environmental regulations. Thousand of tons of composite scrap matter is produced every year by industries who manufacture copper laminas, electrical and electronics products, world wide. Up today no radical solution has been established capable of recycling efficiently this type of scrap materials. As a result, the mai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Genetic dissection of the SEMA3C/Neuropilin 1 signalling pathway in Chronic Kidney Disease progression' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Regardless of the initial insult, human Chronic Kidney Disease (CKD) is characterised by progressive destruction of the renal parenchyma and the loss of functional nephrons.  Renal fibrosis is the common end point of CKDs, the hallmark of which is the deposition of pathological matrix by myofibroblasts.  The worldwide incidence of CKD has reached epidemic proportions with an estimated 10-14% of the adult population known to have CKD.  A key challenge for medical planning is to better understand the mechanisms of CKD progression in order to target pharmaceutical interventions at the early stages of the disease.  Semaphorins are guidance proteins which influence cellular morphology and function, and play important roles in organogenesis and disease.  We found that the secreted glycoprotein SEMA3C was upregulated in two mouse models of kidney injury and in prealbuminuric stages of paediatric CKD patients.  We also found that its receptor NRP1 was expressed in proliferating extracellular matrix-producing cells during CKD progression.  We propose to use genetically engineered mice to investigate the function of the SEMA3C/NRP1 signalling pathway in CKD progression with three major objectives: 1.  Investigate whether SEMA3C and its receptor NRP1 promote CKD progression by analysing the levels of surgically-induced renal injury in mice deficient for Sema3C and Nrp1.2.  Provide an improved mechanistic understanding of the disease by using cutting-edge technologies to unravel new signalling events promoting myofibroblast production and microvasculature rearrangement during kidney injury.3.  Assay the use of SEMA3C as a potential biomarker in the diagnosis of CKD and its progression.   This work will substantially contribute to our current understanding of the pathophysiology of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of Auxiliary Power Unit for Recreational yachts' under Seventh Framework.

assistant: **Concept**

IIn Europe there is a very narrow technology base in portable fuel cell systems which can be applicable for various areas like emergency and remote power, recreational applications, personal portable power and educational devices. The PURE project targets these markets with the primary focus on maritime applications with a device, which will be portable, low weight and volume, based on improved HT PEM fuel cell technology. This proposal describes the project in which a fuel cell system will be designed, build, tested and demonstrated with emphasis on meeting all major technical requirements the codes and standards required to be integrated in a maritime application.The objective of the PURE project is to create a system fueled by propane/LPG, which is converted into a hydrogen rich stream and subsequently fed into a HT PEM stack based on PBI technology. In the end the system delivers electric power to a cover the hotel power demand of a small yacht. The use of off-the-shelf, mass-produced components and design practices both developed in previous European funded projects will result in a small system which is low cost and able to reach the specifications.The consortium gathered to work in this project is a combination of partners who have experience in:1. Defining the market requirements, codes and standards of the system2. Translating these requirements into technical specifications and models3. Designing and building prototype systems4. Testing and validating the systems in laboratory environment and through real lifedemonstration in a yacht.This covers the value chain of the system under discussion.The final result will be two working prototypes of the PURE system, which will be demonstrated under laboratory environmental condition and in a real ship to show that it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Interactive Extreme-Scale Analytics and Forecasting' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

At an increasing rate, industrial and scientific institutions need to deal with massive data flows streaming in from a multitude of sources. For instance, maritime surveillance applications combine high-velocity data streams, including vessel position signals emitted from hundreds of thousands of vessels across the world and acoustic signals of autonomous, unmanned vessels; in the financial domain, stock price forecasting and portfolio management rely on stock tick data combined with real-time information sources on various pricing indicators; at the fight against cancer, complex simulations of multi-cellular systems are used, producing extreme-scale data streams in an effort to predict the effects of drug synergies on cancer cells. In these applications, the data volumes are expected to dramatically grow in the future. Processing this data often requires not only using an HPC infrastructure, but also having data scientists, who are typically not expert programmers, program complex workflows, with a vast number of parameters to tune through time-consuming repeated programming and testing.INFORE will address these challenges and pave the way for real-time, interactive extreme-scale analytics and forecasting. The ability to forecast, as early as possible, a good approximation to the outcome of a time-consuming and resource-demanding computational task allows to quickly identify undesired outcomes and save valuable amount of time, effort and computational resources, which would otherwise be spent in vain. Consider, for example, the ability to forecast the outcome of a complex multi-cellular system simulation for tumor evolution, without the need to wait for the simulation to be completed.  INFORE will also design and develop a flexible, pluggable, distributed software arch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Swine-farm revolution' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

During recent decades, the negative environmental impacts of livestock production and manure handling have been controlled by stricter regulations for manure storage and spreading. However, the intensification of livestock production has led to larger herds on fewer farms and industrial scale operations that produce large quantities of manure at centralised locations. As intensive livestock farming is being placed under increasing pressure to minimise the environmental impact of its operations several number of processes have been assessed as Best Available Technologies (BAT) for manure treatment while at the same time improving utilisation of the nutrient resources.However, most of the state-of-the-art solutions (SoA) are neither technologically, nor economically viable nowadays, and the most important fact, they are usually subjected to national subsidies to be profitable.EUROGAN is based in Spain (one of the largest pig producer and exporter countries worldwide) and have been active in the livestock sector since 1964. Our company, moved by real customer demand and aiming to exploit pig slurry business potential, has recently patented an innovative manure treatment process that accomplishes:1. The concentration of contaminants in the manure (nitrogen, phosphorous, metals, bacteria, virus…) is minimized.2. Treating the pig slurry at its origin3. Its technical and economic viable for the farmer, being independent from national subsidies.4. valorizes the manure (energy recovery and fertilizer)The DEPURGAN project aims to bring to the market an efficient pig manure treatment process, with an initial investment 4 times lower compared to other solutions and operation costs being also very competitive. It base its innovative character in the use of an optimized electrocoagul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Synthetic carbohydrate-based vacinnes'.

assistant: **Concept**

A fully synthetie candidate meningococcal vaccine will be developed which is composed of a synthetic carbohydrate B-epitope derived from meningococcal LPS, a synthetic peptide T-epitope and a lipopeptide. The synthetic methodology will be of general importance for synthetic carbohydrate-based vaccine development. The physical properties of the glycoconjugates will be studied by eleetron microscopy. The conjugates will be tested for T-cell recognition and experiments will be performed with peripheral blood mononucleated cells from HLA-typed volunteers. The conjugates will be used to evoke antibodies in mice and the T-cell-dependent properties of these antibodies will be examined. The antibodies will be determined by ELISA inhibition studies. The research will also provide a further understanding of the requirements for the induction of relevant T-helper reponce.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mammalian Cell Surface Reorganization During Cell Division' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Cell division is a fundamental process by which all living things propagate. The cell surface is the only part of the cell that communicates with its environment, and is thus of critical importance for tissue development, homeostasis and disease. Almost all aspects of the cell’s interior undergo dramatic reorganization by the entry into mitosis and these changes have been extensively studied. In contrast, very little is known about how the cell surface changes during cell division, though surface changes are likely to be important in metazoan tissues and cancers. To investigate the cell surface reorganization during cell division, I took advantage of the quantitative proteomics analysis of cell-cycle to evaluate the changes in the cell surface as cells progress through mitosis.The proposed research will focus on proteins that we identified in our proteomic analysis as strongly up regulated on the cell surface in mitosis. Because, i) such regulation is unprecedented, and its mechanism is unknown, ii) these are rare changes, suggesting a single unique mechanism, and iii) a cell-surface biomarker for mitotic arrest could be useful for improving anti-mitotic cancer chemotherapy. Investigation of mitosis dependent surface-exposed proteins will reveal novel biological regulation, for example how dividing cells loose adhesion and cell round up, and also how mitotic cells interact with the extracellular matrix and communicate with their neighbors in tissue. I identified two members of the protocadherin family that are enriched on the mammalian cell surface as cells move from interphase to mitosis. This proposal will examine the upstream cellular mechanisms that cause cell cycle dependent surface exposure as well as the downstream consequences at the cellular and tissue levels.