RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Web for schools', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The Web for Schools (WfS) project seeks to make substantial contributions to the creation of the Information Society by preparing the ground for a concerted effort to establish a community of teachers all over Europe, ultimately large enough for self-sustained growth, who are able, in terms of skills and infrastructure, to use and contribute to a network of people involved in the production of electronic educational material.It should be clear that the Information Society cannot be equated with an infrastructure such as the Internet, but should be regarded as a society of people able to cope with the fast changing Information Technology (IT) and who are skilled in making effective use of IT in obtaining its goals.Education in this field can not be deferred just to higher education as only some 30% of young people follow higher education in Europe as opposed to 70% in the US and 50% in Japan. Schools must educate their pupils to become the effective change agents of tomorrow. Eventually IT must be employed in classrooms in a variety of subjects, such as art, history, music, mathematics, languages, etc.Although many local and international initiatives exist in this area, they are mostly directed towards the creation of an infrastructure. While this is an essential prerequisite, it does not constitute an information society. It is the way this infrastructure will eventually be used that will make the difference. Hence, a shift of focus towards community building and skill transfer, the expected problem areas a few years from now, is required. The WfS project focuses on putting the WWW and Internet technology to use in the classroom in a pedagogically sound manner.In order to reach a critical mass from where infrastructure, skills transfer, and community building will reach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Embryonic stem cells for therapy and exploration of mechanisms in Huntington disease', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Embryonic stem cell (ES) lines have potential interest for exploring mechanisms and therapeutics of genetically-determined diseases, due to their fundamental attributes, unlimited expansion and pluripotency: isogenic cells of any phenotype can be produced in any requested amount. STEM-HD aims at validating this potential for Huntington's disease (HD), on the basis of the analysis of ES cell lines expressing the mutant HD gene. These will be obtained either following derivation after pre-implantation genetic diagnosis from an embryo expressing the mutant hunting tin gene (existing cell line) or through engineering of existing native human and mouse ES cell lines.The consortium will:- establish protocols to enrich ES cell progeny in cell phenotypes of interest, in particular striatal GABA neurons.- design and implement infrastructures for mass cell production and long-term cultures of ES cells either undifferentiated or following guided differentiation.- identify, using large-scale resource-driven" approaches, HD biomarkers in mutant HD-expressing ES cells progeny appearing as alteration in the expression of genes (transcriptome). Mutant-association of these molecular markers will be validated using patients' samples and assays developed.- explore the mechanisms of the diseases in the mutant HD-expressing ES cells progeny using functional genomics (RNAi and gene over-expression) and "hypothesis-driven" approaches.- perform high content drug screening on HD gene-carrying ES cell progeny using validated biomarkers as signals and available compounds libraries."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeting G-quadruplex DNA Structures in Bacteria to Combat Antimicrobial Resistance' (G4-AntiBac), addressing dissemination and exploitation.

assistant: **Impact**

There is a pressing need to develop new antimicrobial approaches to combat bacterial resistance to antibiotics.  Pseudomonas aeruginosa – a dreadful Gram-negative bacterium pathogen associated with severe acute and chronic human diseases – is responsible for 10-15 % of hospital-acquired infections worldwide. Thus, it is important to identify new biomolecular targets in bacteria and design new molecules that can selectively target them. This project aims to study G-quadruplex DNA (G4 DNA) structures as a new bio-molecular target for the development of new classes of antibiotics. G4 DNA is a non-canonical structure of DNA whose formation has been associated to a number of important biological processes. While the function of G4 DNA is well established in eukaryotic cells, far less is known about their functions in bacteria. Preliminary data from the host group has shown that G4 DNA’s can form in gene promoter regions of the genome in P. aeruginosa. They have also shown that metal complexes can bind to this G4 DNA regions and display antibacterial activity. In this project, I propose to develop novel compounds (via a ‘target-guided synthesis’ approach) that can specifically bind with high affinity to G4 DNA structures of relevance to bacteria. If the newly developed bacterial G4 DNA binders exhibit low cellular uptake, I propose to implement the well-established liposomal delivery strategies to improve their uptake into the targeted bacterial strains. Finally, the highly active compounds will be used to study the proposed gene regulatory role that G-quadruplexes play in P. aeruginosa. My proposed research falls under one of the key priorities (i.e. Infectious diseases and improving global health) of the Horizon-2020 work programme. The outcome of the proposed study will ha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'e-Infrastructures Reflection Group Support Programme 2' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

The e-Infrastructures Reflection Group Support Programme 2 (e-IRGSP2) project provides full support to the work of the e-Infrastructures Reflection Group (e-IRG). The e-IRG has been instrumental in the development of the policies and documenting the best practices, producing five white papers and a roadmap presenting the consensus of the leading European Grid and networking infrastructure experts. The e-IRGSP2 uses the experiences of the previous support action (e-IRGSP), combined with an in-depth analysis of the evolution of the e-IRG itself, to plan for an optimal support strategy. The activities of the project are based on supporting the process of the e-IRG, modelled as an iterative repetition of four phases: (1) Studying the state-of-the-art and best practices, (2) Creating scenarios based on the data (white papers and roadmaps), (3) Establishing consensus about the actions needed (e-IRG recommendations) and (4) Engaging with the necessary stakeholders. The support is based on three services: Secretarial support, which is involved in all of the activities. Its role is central in enabling e-IRG to study the state-of-the-art and engage with the necessary stakeholder groups through communication and dissemination support. Support for the policy activities provides  rapid analysis of the impact of the developments on relevant levels (policy, technical, usage patterns) of e-IRG goals. The activity takes the input generated in the phase 1 through the next two steps. Liaisons with research and other stakeholders focuses on identifying the key activities, developments and trends emerging in the world surrounding e-IRG. It facilitates dialogue about the interplay between the opportunities, goals and gaps related to the e-IRG vision and the surrounding legal, technical and s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Clean Black Sea Working Group' to be submitted under Sixth Framework.

assistant: **Abstract**

It is widely recognized that the Black Sea faces serious environmental problems. Some of the major European rivers e.g. Danube, Dinper, Dnester, Bug discharge into the Black Sea carrying significant pollution loads. About one third of the land area of continental Europe drains into this semi-enclosed sea, which is connected to the Mediterranean through the narrow Bosphorous Channel. The increased pollution load that enters the Black Sea has led to significant deterioration of the marine ecosystem and a sharp decline of fisheries resources. The main aim of this SSA project is to organise future European and regional research activities under an EC-FP6 financed project, for the elaboration and implementation of a new strategy about i) mitigation of the Black Sea negative impacts and ii) sustainable environmental management of the Black Sea region. The objectives of this SSA project are: to establish an international, interdisciplinary Clean Black Sea Working Group involving experts from different fields (e.g. marine scientists, decision makers and policy makers) coming from Black Sea, Eastern Mediterranean and other European countries related to the Black Sea environmental problems; to organise a meeting of this group. The aims of this meeting shall be: exchange of resent information and experience, discussions on measures for minimizing the pollution, establishment of links for collaboration; to prepare a new competitive Clean Black Sea STREP with the framework of FP6 that will in turn produce innovation strategies for minimizing the discharge of pollution and for achieving sustainable environmental management in the Black Sea area. For this purpose a project consortium with the participation of all countries presented in the Working Group will be established. The projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Online Predictive Tools for Intervention in Mental Illness (OPTIMI)' in the context of a Seventh Framework call.

assistant: **Objectives**

Mental health care represents over a third of the cost of health care to all EU nations. However little is being done to develop effective systems for Prevention of the onset of the illnesses or to provide easier Diagnosis with a view to better determine the effects of treatment.OPTIMI will change this by developing tools to perform Prediction through early identification of the onset of an illness by monitoring poor coping behaviour. It is based on the hypothesis that the central issue and starting point of longer term mental illness depends on the individual's capacity and ability to cope with stress.OPTIMI will first identify the occurrence of high stress in the individual on a daily basis. Then it will determine the ongoing effect of stress on the individual by studying the behaviour pattern over a longer period. Finally it will also make estimates of the base line changes in the person's state of mind using symptomatic measurements that closely link depression with cognitive, motor and verbal behaviour. We will use wearable and domestic appliances and identification will be based on noting when stress occurs, at a fine time resolution using ECG and Cortisol, and daily using the Electronic Diary. The effects on behaviour will be identified using EEG, Voice analysis, Physical Activity analysis and the Electronic Diary. Finally specific markers of depression will be checked using EEG, Voice analysis and Physical Activity.The smart sensors will be enhanced with a knowledge based rule system to interpret the data and provide a diagnostic tool for both pharmacological and CBT based preventative and intervening treatments. We will then augment two existing CCBT systems to use these tools in real time to optimise the treatment cycle. We will conduct two phases of trials wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Survey on health, ageing and retirement in europe (SHARE)' to be submitted under Fifth Framework.

assistant: **Abstract**

We propose to initiate a longitudinal Survey on Health, Ageing and Retirement in Europe (SHARE) as a fundamental resource for science and public policy. The pro-jest brings together scientists from many disciplines, including epidemiology, sociology, statistics, psychology, demography, and economics. Scientists from some countries will be involved in feasibility studies, experiments, and instrument development, culminating in a survey of about 12000 individuals over the age of 50 in 8 EU-countries. The multidisciplinary nature of the data (freely available to the research and public policy community) will provide new insights in the complex interactions between economic, healths; psychological and social factors determining the quality of life of the elderly. These interactions, along with pertinent methodological findings, will be detailed in a series of reports emanating from the project, laying the foundation for a longitudinal SHARE in all EU-countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Extending ICT research co-operation between the European Union, Eastern Europe and the Southern Caucasus' to be submitted under Seventh Framework.

assistant: **Abstract**

The European Union promotes the scientific and technological co-operation with the Eastern European and Southern Caucasus (EESC) countries, aiming firstly to restore and reinforce their research capacity and secondly to integrate them in the European Research Area. The Seventh Framework Programme comprises one of the main instruments that is exploited towards this direction, as international co-operation represents an important dimension of it.<br/>The EXTEND project addresses the need for enhanced scientific and research co-operation between the EESC countries and the EU, focusing specifically on the Information and Communication Technologies theme of the FP7's Co-operation Programme. EXTEND aims to support the ICT research communities in the region by: (a) identifying suitable ICT research actors per country, training them on the procedural aspects of FP7 and providing assistance in developing networks across Europe and (b) defining future ICT research priorities that will enhance co-operation between the EU and EESC countries.<br/>The specific objectives of the EXTEND project are to:<br/>(1) Identify key ICT research actors (including academic, private IT sector and not-for-profit research actors) in the EESC countries that are suitable for participation in future ICT research activities.<br/>(2) Develop recommendations on ICT research priorities that are suitable for co-operation between the EU and EESC countries, for the period 2010-2015 following consultation with key ICT research stakeholders.<br/>(3) Provide training on FP7 ICT programme opportunities, procedures and thematic priorities to the identified ICT research actors as well as familiarise them with the European R&D culture.<br/>(4) Facilitate the development of networks between ICT research actors in EES
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Neuronal circuits for emotions in the ventral CA1 hippocampus' (2014-2020).

assistant: **Concept**

A fundamental objective in modern neurosciences is to understand the neural mechanisms of learning and memory in both healthy and pathological conditions. The hippocampus is a high-order cortical brain region important for emotions and cognition. The ventral subdivision of the hippocampus (anterior hippocampus in primates) is mostly involved in anxiety and contextual fear conditioning behaviours. Pyramidal cells of the CA1 region of the hippocampus represent a main hippocampal output to numerous brains regions relevant for emotional and cognitive processes. The activity and timing of these CA1 pyramidal cells are controlled by a set of very diverse long-range afferent inputs and by local GABAergic interneurons. However, the function of afferent pathways to- and of local GABAergic interneurons in the ventral CA1 hippocampus during contextual fear conditioning and anxiety behaviours have not been investigated so far. We hypothesise that distinct sub-circuits in the ventral CA1 hippocampus differentially contribute to emotional behaviours by diverse and complementary neuronal and network mechanisms.To test this hypothesis, we will use an innovative cross-level approach combining single-unit recordings of ventral CA1 GABAergic interneurons and of afferent brain regions to the ventral CA1 hippocampus, local field potential recordings, selective optogenetic strategies, cell-type-specific viral tracing, juxtacellular recording and labelling from ventral CA1 GABAergic interneurons, and behavioural paradigms in rodents. The originality of the proposal relies on identifying specific neuronal circuits and mechanisms in the ventral CA1 hippocampus to understand how normal and pathological brain function might arise at the behavioural level. Altogether, my research proposal aims at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'MOSAICC workshop on intellectual property rights related to microbial genetic resources' under Fifth Framework.

assistant: **Concept**

The project aims at providing information on intellectual property rights (IPR) related to microbial genetic resources (MGRs) and at promoting European standards for accessing and exchanging MGRs as developed in the DG XII funded concerted action MOSAICC - Micro-Organisms Sustainable use and Access regulation International Code of Conduct". A one-day workshop will be organised as satellite event of the Ninth International Congress for Culture Collections (Brisbane, 23-28 July 2000). Beforehand, a survey within the World Federation for Culture Collections (WFCC) will produce a Frequently Asked Questions list to be used to define the workshop contents, prepared and presented with experts of the World Intellectual Property Organisation, the European Culture Collections Organisation and the WFCC Patents and WFCC Biodiversity Committees. A vade-mecum on IPR related to MGRs intended to all users of MGRs will summarise the compiled information."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Globalizing Palliative Care? A Multi-sited Ethnographic Study of Practices, Policies and Discourses of Care at the  End of Life' (ENDofLIFE), addressing dissemination and exploitation.

assistant: **Impact**

This project will undertake a comparative and multi-scalar medical anthropological study of the globalization and cultural mediation of palliative care practices, policies, and discourses. Its central objective is to gain insight in what is universally shared and what is culturally specific in end-of-life care, by analyzing how local end-of-life care practices impact palliative care and how globally circulating discourses of palliative care are transforming local notions of death and dying.In a few decades, palliative care has become widely associated with a good death in high-income countries. Given the current international attention to expanding palliative care to the global south, in particular in relation to the notion of a human right to palliative care, it is essential that we better understand how palliative care does or does not translate across diverse cultural contexts. To this end, this project will research: 1. Why palliative care is expanding globally 2. How palliative care practices, policies and discourses are translated, adapted and reconstituted in diverse socio-cultural settings 3. How this process is impacted by culturally diverse, non-institutional practices of end-of-life care and notions of good dyingThe break-through scientific question that this research will address is: What is universally shared and what is culturally specific to practices of end-of-life care and notions of good dying?Building on the PIs previous research on morality and AIDS care, this project develops a novel analytical approach that focuses on the dynamic interaction between the global mobility and articulation of palliative care discourses, national-level institutional care assemblages, and local end-of-life care trajectories. To discover how this interaction works in prac