RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Super-Resolution deciphers DRP1's Cut: Mitochondrial Fission during Apoptosis via SMLM and MINFLUX' (SuperCut).

assistant: **Innovation**

Illnesses such as neurodegenerative diseases and cancer represent significant public health challenges due to their increasing prevalence, mortality rates, and societal impact. Mitochondrial dysfunction, specifically the dysregulation of mitochondrial fission, is implicated in these diseases.Together with mitochondrial fusion, the mitochondrial fission process,  or the division of mitochondria, is essential for maintaining cellular health. The effector protein of mitochondrial fission is the dynamin-related protein 1 (DRP1). During cell death, mitochondrial fission is elevated and DRP1 interacts with the key apoptotic proteins BAX and BAK. However, the precise role, regulation, and positioning of DRP1 in mitochondrial fission, especially with regards to BAX and BAK during apoptosis remain unclear.The project SuperCut will unravel the molecular architecture of DRP1 as well as its motion pattern during mitochondrial fission in the context of apoptosis by using advanced super-resolution microscopy techniques. Single-molecule localization microscopy (SMLM) will enable the visualization of the spatial organization of DRP1 and its relation to apoptotic pore formed by BAX and BAK. MINFLUX tracking will provide insights into the spatial dynamics of DRP1 and its adaptors in healthy cells and their interaction with BAX and BAK in apoptotic cells. By elucidating these mechanisms, the project will open new avenues for innovative therapeutic strategies targeting dysfunctional mitochondrial fission.The research for SuperCut will be conducted by me, Dr. Sarah Schweighofer at the Max Perutz Laboratories under the supervision of Prof. Jonas Ries, leveraging cutting-edge microscopy techniques to push the boundaries of our understanding of mitochondrial dynamics in health and disease. Thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'DetEction of skin canceR: integrating Morphoelastic theories in biomechanical Analysis (DERMA)' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Skin cancer is the most common cancer in humans, becoming a public health problem of growing concern. Its diagnosis is difficult in the beginning when the tumour is small and specific criteria are still missing.. Clinical examinations alone have a rather low specificity and sensitivity: many benign lesions are over-diagnosed leading to unnecessary surgery; while some malignant ones might remain undiagnosed or be diagnosed too late. The scientific target of the DERMA proposal is to propose both a multidisciplinary approach and new interpretative models of the complex phenomena underlying skin cancer evolution, possibly leading to technology proposals for early diagnosis in clinical dermatology. The intent of investigating the biomechanical bases of skin cancer evolution is perceived through multidisciplinary research activities, with the interwoven backgrounds of applied mathematics, biomedical engineering, biomechanics, and dermatology. The work is structured for further understanding of the paramount biomechanical characteristics governing the process of cancer invasion, with the following objectives: Obj. 1: developing a mathematical description of the phenomena underlying skin cancer evolution, to be used as an input for a growth theory of malignant lesion. Obj. 2: modelling the mechanical characteristics of benign and malignant lesions through the development of different methods referring to the skin cancer biomechanical investigation. Obj. 3: delivering a cost-effectiveness study for an integrated diagnostic instrument for predictive and personalised early detection of skin cancer. The integration of biomechanics, computer science, applied mathematics, and optics is an innovative concept in the design of clinical instrumentations. The DERMA proposal has the potent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A renewable bio-based material that enables efficient, cost-effective production of high-quality insulation, packaging, dry-wall, and other building materials' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Mycotaff is an advanced bio-material designed using mushroom mycelia as a non-toxic binder agent that enables the production of affordable, environmentally friendly and recyclable building materials, for a wide range of applications, from agricultural waste. Mycotaff materials have a low embodied energy and can be manufactured for a cost ~80% cheaper than those made from traditionally used materials such as gypsum board or clay brick. It is ten times more lightweight than these materials and has better production efficiency, allowing for faster construction. Mycotaff is a toxin-free green technology that complies with all imposed EU regulations, is fully biodegradable, and is produced with abundantly available agricultural waste. Its production produces 90% less carbon emissions compared to typically used materials. It is easily customizable for its range of applications, Class A fireproof, and has a low U value of 0.16 W/mK making it an ideal material for insulation, packaging and other building applications.The SME Instrument project aligns itself perfectly with the innovation strategy and mission of Mycotech: to commercialise an affordable, sustainable, and durable biomaterial. Mycotech’s products for building materials (panelling and insulation) will be the technology’s initial test-bed. The results of the project will allow the company to move forward also with the other future applications (packaging, pallets, prefabrication walls etc.).We have developed strategic partnerships with several leading research institutions and companies involved in big impact projects in the field of bio-based construction. Mycotech’s ambition is to disrupt the building materials market by producing sustainable products with high quality and design that has previously been impossible.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Credible Inference for Empirical Macroeconomics' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Following the credibility revolution, macroeconomists have sought plausibly exogenous instruments and other sources of variation to identify causal effects. Given the complex nature of the macroeconomy, characterised by simultaneous causality and intemporal dependence, this is a high bar. Thus, in the pursuit of exogenous variation, researchers often use minor sources of variation or subtle features of the data to identify the effects of interest. When the variation exploited is modest, “weak identification” can arise. In practice, this means that estimators are no longer asymptotically normal, so standard techniques for statistical inference – conducting hypothesis tests or constructing confidence intervals – are invalid. While this likely occurs in much empirical research in macroeconomics, few papers acknowledge these issues, partially because there are rarely appealing options to address them. This proposal provides attractive options for researchers to combat weak identification in macroeconometric models. First, it offers the possibility to avoid weak identification in the first place, via novel frameworks to exploit instrumental variables in panel and time series data. These frameworks extract richer information from a given instrument and expand the set of admissible instruments. Next, I provide tools to construct confidence sets for dynamic causal effects, a key object of interest, that are valid regardless of how strong the identifying variation is. Existing approaches produce confidence sets that are conservative – too large. I first consider models identified using instrumental variables, improving both computational burden and performance relative to frontier methods. Finally, I consider models identified using more general sources of variation, and, workin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'microRNA assay system based on self-assembled nanoscale DNA origami arrays' (2014-2020).

assistant: **Innovation**

MicroRNAs (miRNAs) are potential biomarkers for cancer diagnosis, prognosis and treatment monitoring. Specific detection and absolute quantification of miRNAs is of clinical relevance for early cancer detection and monitoring progression. The currently available techniques for miRNA detection based on DNA amplification are limited by lack of absolute quantification, low multiplexing capacity and time consumption. Here, I propose to develop a miRNA assay system based on self-assembled nanoscale DNA origami arrays (miRanDa) for the simultaneous detection of multiple miRNA targets from breast cancer cells and plasma by using DNA-PAINT, state-of-art super resolution technique. The formation of specifically configured finite 2D lattices of self-assembled DNA origami structures based on sticky-end hybridization will further improve the capacity of the detection system beyond the currently available techniques. This assay can be further developed and adapted to the rapid, specific, sensitive and multiple detection of additional nucleic acid species, such as ctDNA, mRNA or lncRNA.


**Keywords:** microRNA, biomarkers, diagnostics, DNA nanotechnology, DNA origami, DNA-PAINT, super resolution microscopy, breast cancer, self-assembly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Point-Of-Care MONitoring and DIagnostics for Autoimmune Diseases' (POCEMON), addressing dissemination and exploitation.

assistant: **Impact**

The POCEMON project aims to the hardware and software development of a multi-purpose autoimmune diseases diagnostic platform by combining Lab-on-Chip (LOC) technologies, genomic microarrays of HLA (human leukocyte antigens) typing, microelectronics, mobile devices, intelligent algorithms and wireless communications. The multi-purpose platform will be provided as a portable integrated platform with application to primary care level. The final product will be capable to communicate through its PDA device with the Laboratory Information Server (LIS) for detailed analysis, diagnosis and information extraction concerning autoimmune diseases; the LIS will be also developed inside the time-framework of the project. Microelectronics-microfludics for the LOC and robotics for the HLA microarrays' construction, constitute the main state-of-the-art scientific technologies which will be employed for the development of the portable diagnostic genomics laboratory.Autoimmune disorders (diseases) develop when the immune system destroys normal body tissues. HLA genes are the major determinants used by the body's immune system for recognition and differentiation of self from non-self (foreign substances). The combination of LOC technologies with genomic microarrays of HLA typing will provide a state-of-the-art diagnosis at primary care level, concerning multiple sclerosis and rheumatoid arthritis which are linked with the HLA CLASS I and II genes. The development of a primary care diagnostic LOC platform based on microarrays of HLA typing is the main target of this proposed project. Easily adapted developments will lead to the diagnosis on the majority of autoimmune disorders. The POCEMON platform will advance and promote primary health care diagnosis across Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A novel approach to determine canopy nitrification in the phyllosphere of European forests: combining multiple isotope tracers and proteogenomic techniques'.

assistant: **Concept**

Forest canopies play a significant role in regulating carbon and water exchanges with the atmosphere, with profound effects on our climate. However, their role in altering the chemical composition of precipitation and, consequently, the nutrient cycling within a forest has been less investigated. This is particular relevant for nitrogen (N)-limited forests in the Northern hemisphere, which have been exposed to a rapid human-induced increase in Ndep over the last decades. Much of the  scientific attention has been focused on the role of Ndep in enhancing forest C-sink, while we still need to elucidate the fate of Ndep when entering forest and its contribution to N cycling. In particular, it is still not clear whether Ndep is retained, taken up and/or altered by biological transformations when interacting with tree canopies. By applying a quadruple isotope approach I recently demonstrated the occurrence of in-canopy biological nitrification of atmospheric N for UK forests at high Ndep. Hence, NITRIPHYLL intends to extend the multiple isotope approach a) to enlarge the range of conditions under which the process is demonstrated to occur, b) to investigate difference between species in the proportion of microbiologically-derived NO3 and c) the reasons of these differences. Furthermore, by using proteo-genomic techniques we aim to characterize phyllosphere microbial communities involved in canopy nitrification. We will consider i) forests along  a gradient of climate and Ndep within the well established EU-ICP forest network and ii) existing N manipulation experiments. NITRIPHYLL for the first time merges two separate research avenues, i.e., the investigation of canopy nitrification with the study of the occurrence, abundance and diversity of bacteria communities in the phyl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a new generation of bacterial live vaccine carriers: Brucella, Salmonella and Yersinia' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The major objective of this proposal is to develop a new generation of safe and effective bacterial live carriers which are suitable for oral vaccination. To achieve this overall objective a multi-disciplinary collaboration has been set up between four academic institutes and one European vaccine company. In the proposed project all partners are dedicated to assess systematically the potential of attenuated Brucella, Salmonella and Yersinia strains to protect against infectious diseases. Vaccine induced protection often depends on the ability to elicit immune responses against a specific peptide or epitope in a fashion that mimics natural infection. The possibility of delivering an antigen into different processing and presentation pathways promises to be a powerful tool for designing vaccines. In this study a major immunogen of Listeria monocytogens, the p60 protein, will serve as a model antigen that has to be delivered by the different bacterial live carrier. By genetic manipulation of microorganisms and the use of different bacterial secretion systems the p60 antigen will be specifically targeted into either the extracellular, endosomal or cytoplasmic compartment of infected cells. Consequently, different branches of the immune response are expected to be stimulated: Extracellular antigens are known to be eliminated by antibodies, whereas cytosolic antigens are presented to CD8 T-cells via the MHC class I pathway. Antigens derived from endosomal compartments are processed by the MHC class 11 pathway and recognized by CD4 T-cells. Within the scope of this project the newly designed carrier expressing the p60 antigen will be used for in-vitro and in vivo experiments to determine antibody responses, cytokine profiles and T-cell subsets subsequent to infection of variou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Robot standards and reference architectures' under Sixth Framework.

assistant: **Concept**

The objective of RoSta is to proactively take the initiative on the definition of formal standards and the establishment of de facto standards in the field of robotics, especially service robotics. The project does not aim at a broad coverage of topics, which might lend themselves towards a standardisation. Rather we intend to take the initiative in the formulation of standards in a very few, selected key topics which have the highest possible impact. These topics are at the core of robotics research and development, and therefore have the potential to form the root of a whole chain of standard defining activities going far beyond the specific activities of RoSta.More specifically the technological objectives are to coordinate a set of actions initiating and preparing a set of standard defining activities on the following topics of advanced robotics:1. Creation of a glossary/ontology for mobile manipulation and service robots2. Specification of a reference architecture for mobile manipulation and service robots3. Specification of a middleware for mobile manipulation and service robots4. Formulation of benchmarks (of components, methods, middleware and architectures) for mobile manipulation and service robotsEach line of activity will result either in- an action plan for a standard defining activity or- an action plan and a recommendation/proposal to the European Commission for a supported activity (e.g. a open-source project with significant financial support in FP7) or- an action plan for a community driven open-source activity with seed-money for example to run a project office or alikeTo translate the above activities into a standard defining activity, a liaison with IEEE Standard has been established. Recommendations or action plans developed in the above activities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Promotion of modern, clean energy and transport technologies and policies in Latin America & the Caribbean' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Conceptually the main Purpose of the OLA project is to help create conditions for incorporating sustainable development as a priority in the formulation and implementation of energy and transport policies in Latin America and Caribbean countries. The specific objective of OLA is to reinforce and coordinate a cluster of OPET-related organizations in a series of countries, aiming to promote clean and modern energy and transport technologies and policies in the region. The project will strengthen capacity-building processes in energy & transport organizations (both governmental and private) in Latin America and the Caribbean countries, taking advantage of European expertise and RTD results in those fields.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Prevention of falls network europe (PROFANE)'.

assistant: **Concept**

PROFANE is a thematic network with 28 partners focusing on the issue of prevention of falls and improvement of postural stability amongst elderly people. It comprises 4 work packages1) taxonomy and co-ordination of trials2) clinical assessment and management3) assessment of balance function4) psychological aspects of falling. The aim is to bring together workers from around Europe to focus on aeries of tasks required to develop multi-factorial prevention programmes aimed at reducing the incidence of falls and fractures amongst elderly people. The work of PROFANE is practical. It will advance the science but it will also aim to change health care procedures to introduce best practice widely across Europe. Each work package will undertake a series of workshops bringing together experts and observers around specific topics. The network will conduct two network meetings to synthesise work from packages and mount a website to disseminate information.