RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Qualitative and Quantitative Social Science: Unifying the Logic of Causal Inference?' (QUALITY), addressing dissemination and exploitation.

assistant: **Impact**

Good public policy should make society healthier, happier, safer, and more productive. Social scientists can help: they can look for the causes that promote or prevent these outcomes. Some do this by building models, which they test against large datasets using statistical tools. Others use non-formal tools, applied to a small number of cases: tracing processes, comparing cases, interviewing participants, writing ethnographies. Policymakers can then try to weigh up all this 'quantitative' and 'qualitative' evidence in order to judge the likely effects of a policy.There are established ways to weigh up the evidence from multiple quantitative studies, and for organizing the evidence from multiple qualitative studies. There are also excellent research designs that yield both quantitative and qualitative evidence. However, it's currently unclear how to weigh up the evidence from multiple qualitative studies, either on their own or together with quantitative studies. For example, how should one judge the efficacy of a policy when the findings from quantitative studies contradict the findings from qualitative ones? This poses a momentous problem: it exposes one's causal judgements to an increased risk of error, as it does any policies based upon these judgements.QUALITY aims to solve this problem by bringing together cutting-edge work in epistemology with the expertise of leading social scientists. It will analyse some prominent qualitative studies in sociology and political science, and it will contrast them with some prominent quantitative studies based on econometrics. QUALITY will then determine whether there is, despite their differences, a handful of basic heuristics for causal inference that underlie both types of approach. If there is, QUALITY will use these heuristic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Decoding and controlling cell-state switching: A bottom-up approach based on enhancer logic' to be submitted under Horizon 2020.

assistant: **Abstract**

Cell-state switching in cancer allows cells to transition from a proliferative to an invasive and drug-resistant phenotype. This plasticity plays an important role in cancer progression and tumour heterogeneity. We have made a striking observation that cancer cells of different origin can switch to a common survival state. During this epigenomic reprogramming, cancer cells re-activate genomic enhancers from specific regulatory programs, such as wound repair and epithelial-to-mesenchymal transition.The goal of my project is to decipher the enhancer logic underlying this canalization effect towards a common survival state. We will then employ this new understanding of enhancer logic to engineer synthetic enhancers that are able to monitor and manipulate cell-state switching in real time. Furthermore, we will use enhancer models to identify cis-regulatory mutations that have an impact on cell-state switching and drug resistance. Such applications are currently hampered because there is a significant gap in our understanding of how enhancers work.To tackle this problem we will use a combination of in vivo massively parallel enhancer-reporter assays, single-cell genomics on microfluidic devices, computational modelling, and synthetic enhancer design. Using these approaches we will pursue the following aims: (1) to identify functional enhancers regulating cell-state switching by performing in vivo genetic screens in mice; (2) to elucidate the dynamic trajectories whereby cells of different cancer types switch to a common survival cell-state, at single-cell resolution; (3) to create synthetic enhancer circuits that specifically kill cancer cells undergoing cell-state switching. Our findings will have an impact on genome research, characterizing how cellular decision making is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'MINT ERA-NET From Micro- and Nanoscale Science To New Technologies for Europe' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Micro-Nano-Technology (MNT) is a key enabling technology covering the fields of micro-technologies, nanotechnology and microsystems. MNT is expected to impact significantly on future economic and social development. It will stimulate new products and services, create and secure employment in Europe and improve living conditions, including of people who presently lack autonomy as a result of age, illness or accidents. MNT will also contribute greatly to meeting ecological challenges and achieving sustainable development, innovatively and economically. The main objectives of MNT ERA-NET during the four years are: * to exchange among the participating programmes strategic information about programme design and management; * to learn from each other through the exchange of good practice; * to implement joint and coordinated activities among participating programmes so as to add value for programme users, programme managers and programme owners; * to secure mid-term cooperation between the participating programmes through a detailed action plan; * to expand the project to further countries and regions in Europe so as to broaden its impact, and * to establish long-term cooperation by exploring options and selecting and implementing a preferred institutional framework for sustained co-operation between the participating programmes, other European intiatives and other relevant stake-holders. Europe currently holds a good scientific and technological position in MNT, but in comparison with North Amerika, Asia and Australia our research and application efforts are dispersed and fragmented. In order to exploit Europe's good position, this dispersion and fragmentation have to be addressed through, inter alia, better co-operation between national MNT programmes on a transnational le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'advanced technologieS for drug dIscovery and precisioN mEdicine: in vitRo modellinG human physiology and diseAse'.

assistant: **Innovation**

A key step in the drug development process is to predict information on safety, efficacy and mechanisms of action of a candidate molecule as early as possible in the pipeline (drug screening). To accomplish this aim, physiological and pathological pre-clinical models that closely approximate the human body are required. The limited capabilities of most of the existing pre-clinical screening tools, unable to meet the physiological relevance required to screen out failing drug candidates, reflect in the current weak performances of drug discovery: high attrition rates indeed affect the process of taking drugs from lab to market. Despite emerging new technologies exist with potential for advancing the field of in vitro modelling, their successfully implementation in the drug discovery pipeline to make it more efficient is still challenging. This is also imputable to a lack of structured dialogue between academic technology providers, market-oriented and regulatory-aware CROs, Biotechs and Pharma companies, which finally affects the research, training and development pipeline. SINERGIA aims at integrating a training network where academic and non-academic actors contribute to unravel the potential of the synergistic and rational use of four key bioengineering technologies. In particular, SINERGIA features academic leading experts of i) organs-on-chip and microfabrication technologies; ii) bioreactor and tissue engineering; iii) 3D Bioprinting; iv) induced-pluripotent human stem cells. These techniques are deployed to CROs and Biotech Consortium members that will ensure rational development, exploitation, validation and compliancy with regulatory and industrial aspects. Ultimately, this concerted action will lead to advanced models of human physiology and diseases to be intr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Studies of Materials and Catalysts by Dynamic Nuclear Polarization Enhanced Solid-state NMR' (DNPMAT).

assistant: **Concept**

Recent innovations in dynamic nuclear polarization (DNP) have transformed the sensitivity of solid-state nuclear magnetic resonance (NMR), resulting in a reduction in experiment time of up to 100,000-fold. This means that previously unobtainable structural details can be quickly obtained by NMR, even for dilute species, such as binding sites in catalysts or  functionalizing molecules at surfaces. The objectives of the action are the improved sample preparation protocols, new experimental approaches and proof of principle studies necessary to make DNP-enhanced solid-state NMR the method of choice for the molecular-level characterization of the surfaces of materials. These objectives will be achieved by knowledge exchange between Dr S. Chaudhari, an experienced researcher with a background in developing DNP, and researchers at the University of Nottingham involved in solid-state NMR studies of materials and catalysts. The action is designed to train Dr Chaudhari though high-quality research into applications of DNP-enhanced solid-state NMR to four technologically useful materials: mesocellular silica foams, alumina catalyst supports, surface-coated hydroxyapatite nanoparticles and model catalytic converters. The training will take place at the state-of-the-art UK Facility for DNP-enhanced solid-state NMR operational at the University of Nottingham since November 2015. The Facility’s instrumentation is unique in the UK and is available to external users from both industry and academia, resulting in a vibrant research environment and a ready-made network of collaborators for Dr Chaudhari. In addition, a secondment at a leading sustainable technology company (Johnson Matthey) will ensure that industrial and commercial aspects are fully integrated into the action. The trainin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'European rice: transgenes for crop protection against fungal diseases'.

assistant: **Objectives**

We propose to improve and evaluate the use of genes expressed and involved in the resist- acne to fungal attack in the control of rice blast and other fungal diseases, as major pests for rice in Europe. Selected resistance genes under inducible or constitutive promo tars will be engineered to create new rice genotypes enhanced for resistance. The oboe- active is the construction of modified cultivars protected against attacks of the pathos- genes as well as to an evaluation of the GM genotypes in the environment. Once resistance had been demonstrated, the programme aims to understanding the mechanisms of action of the new trait acquired at the level of genetics, molecular biology, physiology and path- logy, in an integrated approach. The final objective of the programme is to identify a valuable strategy in terms of crop protection of rice in Europe, associated to an assessment of the impact of GM-rice in the areas where rice is cultivated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Polymeric composite materials with enhanced thermal conductivity properties for heat exchangers applications' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The main goal of the project is to develop a new family of low cost polyolefin based components (sheets, pipes and fittings) to be used in the manufacture of flat-plate solar thermal collectors. These components are expected to be a viable alternative to current collector’s metallic components. However, due the current limitations of thermoplastics materials (low thermal conductivity and low resistant coatings) two main developments will be claimed in this project: • Polyolefin nanocomposites by using different nanoparticles with high thermal conductive properties as additives. • A novel and specific surface treatment based on SAM technology to provide an energy absorber flexible coating (based on metallic oxides, e.g. TiO2 or ZnO) to the different components. These developments will allow novel low cost and low weight components design’s with enhanced thermal conductivity and high solar energy absorption to develop high efficiency thermal collector designs. The use of plastics components instead of metallic ones offers additional advantages: folding and easy assembling structures design, low energy consumption in motorized thermal collectors (follow sun light), corrosion resistance, low friction coefficient (less pump energy consumption), prevent theft or vandalism (due the low cost of components in comparison with copper). The solar thermal collector parts to be substituted by the new thermal conductive materials and flexible absorber coatings will be the extruded pipes and injected fittings of the collector heat absorption circuit and extruded sheets which will be used as absorber plate. In this context, the polymeric materials appear as a real alternative to develop new low cost procedures in which a wide variety of component’s designs could be obtained to optimize
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular indicators of DNA damage in aquatic organisms' (MIDIA).

assistant: **Innovation**

One of the most important early indicators of pollution in aquatic environments is the effect on indigenous animals, including invertebrates such as mussels. While cellular damage studies have traditionally played an important role, advances in medical techniques now make it possible to study pollution-induced damage at the DNA level, offering an earlier and more sensitive indicator. These techniques have been pioneered in the USA and urgently need development in Europe.Dr Rochelle at Sussex is one of the leading European scientists in this field, building inexperience from working in the aquatic toxicology group at Johns Hopkins University before taking up her current Sussex post. This proposal will bring Corona Coca to Sussex, to work on development of DNA damage studies in invertebrates, building on her research work in Romania. This fellowship will provide the expertise to enable study of pollution in the Romanian Black Sea via DNA damage in mussels. Studies have shown that the chemicals taken up from the marine environment by organisms bind to DNA, leading to tumours in a diverse range of species. Tumours have been described finfish species but less is known regarding DNA damage and tumours in invertebrates. In Europe, invertebrates have yet to be investigated at this molecular level. The fellow\'s PhD studies have shown that European mussels do possess tumours in contaminated areas of the European Black Sea. The fellow will learn and apply state-of-the-art molecular techniques for characterisation of mussel cancer genes and proceed to examine their association with pollution-induced tumours. Throughout the project the fellow will immerse within the European scientific community, establish contacts, raise their academic profile and prepare for a future independent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'MAP kinase cascades controlling virulence in fungi: from signals to pathogenicity response'.

assistant: **Objectives**

Filamentous fungi make a devastating impact on agriculture and human health. European agrochemical and medical drug discovery companies face a pressing need for safer and more effective products. The major bottleneck in the development of better antifungal s is the discovery of novel cellular targets. SIGNALPATH is a state-of-te-art post-genome project that used highly sophisticated and integrated genetic, genomic, and bioinformatic tools to sort through the large quantities of information available in genome databases, with the aim of elucidating complex biological pathways and pinpointing potential antifungal targets.Our goal is to identify and validate fungal genes and proteins that play a causative role in disease and can be targeted for inhibition through the intervention of small molecules or antibodies. SIGNALPATH will focus on a set of conserved cellular signalling modules called mitogen-activated protein kinase (MAPK) cascades, which play pivotal roles during fungal infection.A panel of multi-facete d approaches will be used to elucidate three key nodal points of fungal MAPK cascades whose role in disease is currently unknown:[1] the signal inputs that activate the pathway,[2] the upstream pathway receptors and[3] the downstream effectors.To fill the existing knowledge gap, SIGNALPATH reaches across the boundaries of traditionally separated fields such as plant pathology, medical mycology, biochemistry, cell cycle research and bioinformatics to gather a team of leading expert groups with a unique s kill-set in fungal biology, genetics and comparative genomics. The network integrated two world-class companies, Bayer CropScience, a global key player in plant protection and Novozymes, the world leader in microbial enzyme solutions. This dynamic interactive platfor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Collective phenomena in quantum and classical many body systems'.

assistant: **Objectives**

The collective behavior of quantum and classical many body systems such as ultracold atomic gases, nanowires, cuprates and micromagnets are currently subject of an intense experimental and theoretical research worldwide. Understanding the fascinating phenomena of Bose-Einstein condensation, Luttinger liquid vs non-Luttinger liquid behavior, high temperature superconductivity, and spontaneous formation of periodic patterns in magnetic systems, is an exciting challenge for theoreticians. Most of these phenomena are still far from being fully understood, even from a heuristic point of view. Unveiling the exotic properties of such systems by rigorous mathematical analysis is an important and difficult challenge for mathematical physics. In the last two decades, substantial progress has been made on various aspects of many-body theory, including Fermi liquids, Luttinger liquids, perturbed Ising models at criticality, bosonization, trapped Bose gases and spontaneous formation of periodic patterns. The techniques successfully employed in this field are diverse, and range from constructive renormalization group to functional variational estimates. In this research project we propose to investigate a number of statistical mechanics models by a combination of different mathematical methods. The objective is, on the one hand, to understand crossover phenomena, phase transitions and low-temperature states with broken symmetry, which are of interest in the theory of condensed matter and that we believe to be accessible to the currently available methods; on the other, to develop new techiques combining different and complementary methods, such as multiscale analysis and localization bounds, or reflection positivity and cluster expansion, which may be useful to further progress on im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Time-resolved optical and magneto-optical spectroscopy of ii-vi and iii-v semiconductor heterostructures'.

assistant: **Objectives**

Great interest exists in clarifying the optical properties of wide gap semiconductor heterostructures, arising from the possibility of obtaining laser diodes and other optoelectronic devices operating in the blue region of the spectrum. We will perform optical measurements in order to determine the intrinsic parameters (band offsets, ...) of ZnSe/(Zn,Mn)Se and ZnSe/(Zn,Cd)Se heterostructures. This will lead to an improvement of the heterostructures, the final scope being the achievement and evaluation of laser structures. Attention will also be paid to fundamental physical properties which can be of interest for device operation and improve the understanding of those structures. Part of the activity will be devoted to investigation of the dynamical optical properties of single GaAs/(Ga,Al)As quantum boxes or wires and will take advantage of the availibility of a space and time-resolved experimental set-up ruling out all the difficulties arising from the size fluctuations usually encountered in OD or 1D systems.