RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Big Data of Small Molecules'.

assistant: **Innovation**

As Google mapped and photographed the streets and terrain of our planet, the main objective of the project is to map and spectrally fingerprint the small organic molecules of various organisms and introduce to the market a fundamentally new cloud driven compound identification platform.Our pioneering solution will allow continuous identity assignment of unknown molecules in biologically relevant samples by developing a technologically mature architecture and infrastructure for storage, processing, search, exchange, analysis, data mining and visualization of millions of spectral, structural, chromatographic and biochemical data of small molecules.Our project will become the world most comprehensive database platform of spectral fingerprints of endogenous metabolites, natural products and environmental contaminants that will allow identification of substances present in biological samples that could not be identified using conventional technology that is a crucial bottleneck in many biotechnological and pharmaceutical applications.Since the biomedical, pharmaceutical and biotechnology industry in general are constantly detecting numerous unknown compounds and searching for new biomarkers and disease specific targets, our technology platform is direct response to their needs with the prospect of new business opportunities and future growth.The feasibility study will be important for acquiring additional financing of the project, to review technological solution (most effective and sustainable, without infringing patents, copyrights, and trademarks of third parties), to precise marketing strategy for corporate, small group & individual users, to identify, clarify and protect own inventions, new approaches and new technical solutions. Finally, the Phase 1 outputs will give p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The role of lipopolysaccharide in mucosal protection against shigella flexneri infection' under Fourth Framework.

assistant: **Concept**

Research objectives and content Shigella flexneri is the causative agent of endemic bacillary dysentery, a disease primarily afflicting children in developing countries. The pathogenesis of Shigella infection stems from the ability of the organism to invade eukaryotic cells. Once the organism gains entry into the host tissue, intense inflammation and tissue destruction ensue. During natural infection and in experimental models of shigellosis, the immune response against the organism is primarily directed towards epitopes present on Shigella lipopolysaccharide. Additionally, a monoclonal immunoglobulin A (IgA) antibody against a serotype-specific epitope of Shigella LPS is sufficient to protect animals during experimental infection. The objective of this proposal is to understand the mechanisms underlying LPS-specific mucosal immunity against Shigella infection. Two specific objectives form the basis of these studies. The first objective is to examine the ability of anti-LPS IgA to prevent bacterial invasion of eukaryotic cells by blocking bacterial-host cell interactions. Second, the possibility that free LPS taken up by epithelial cells can be blocked by LPS-specific IgA will be examined. Inhibiting either bacterial uptake or the transcytosis of soluble inflammatory mediators such as LPS may prevent the intense inflammatory response and tissue destruction characteristic of Shigella infection. These studies into anti-Shigella mucosal immunity will influence the development and design of vaccines against S. flexneri infection. Training content (objective, benefit and expected impact) Diarrheal diseases cause considerable morbidity and mortality throughout the world. The impact of diarrheal disease is greatest in children, particularly in developing countries. It is estim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Patient specific image-based computational modelling for \nimprovement of short- and long-term outcome of vascular access \nin patient on hemodialysis therapy' (ARCH) targeting Seventh Framework.

assistant: **Abstract**

More than half a million people live in Europe on chronic renal replacement therapy by hemodialysis (HD). This number increases annually at a constant rate of 8%. The Achilles heel of HD is the vascular access (VA) used to connect patient circulation to the artificial kidney. The current recommendation for VA is the native arteriovenous fistula (AVF), surgically created in the forearm. VA dysfunction is the major cause of morbidity and hospitalisation in HD patients, and the major limitation of HD treatment. Short- and long-term AVF dysfunction includes non-maturation (inadequate increase in blood flow after surgery), stenosis due to intimal hyperplasia, and ultimately thrombotic occlusion. Steal syndrome and cardiac failure are also common complications of AVF creation. Prediction and prevention of VA dysfunction are still open clinical challenges with more than 90,000 procedures/year in Europe for revision or reoperation. Despite the magnitude of the clinical problem, there has been a paucity of novel therapeutic interventions in this field due to complex mechanisms responsible for AVF complications, which are closely related to both the sudden and sustained hemodynamic changes involved in AVF creation.The ARCH project will develop image-based patient-specific computational modelling tools to simulate hemodynamic changes induced by AVF surgery and long-term vascular and cardiac adaptation. The modelling tools will be designed and experimentally validated to predict AVF function for improvement of surgical planning and AVF management, and will be provided to clinical end users by a distributed IT infrastructure. Verification of model prediction of AVF maturation, patency, onset of steal syndrome and cardiac overload will be performed on the basis of prospective observa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'An innovative business model, systems and services for market-based habitat banking in Europe'.

assistant: **Objectives**

The objective of our overall innovation project is to boost the growth potential and internationalisation of EBL’s unique and highly innovative business model, systems and services for habitat banking. The subsequently expected outcomes will be: (1) habitat banks demonstrated and critical market mass attained in England (our current market); (2) habitat banks demonstrated and market replicated in Spain (where new regulation provides the most promising entry point for market replication in continental Europe). The overall project will provide a robust springboard for further growth in England and Spain and market replication in other EU countries, allowing us to seize the business opportunity presented by expected growth of a € multi-bn/yr habitat banking market. The specific objectives of this Phase 1 feasibility study are: (1) To fill key gaps in our feasibility assessment for England, through: (a) legal analysis to give clarity to planning mechanisms for habitat banking; (b) market demand studies for three pilot areas (Buckinghamshire, Oxfordshire, Surrey); (c) land manager partner searches for these pilot areas; (d) economic analysis of the cost of operations to create and manage restoration of native grassland; (e) legal analysis of IP protection, or strategy for subsequent commercialisation of licences, for project-derived metrics. (2) To fill key gaps in our feasibility assessment for Spain, through: (a) refining our assessment of potential market demand and supply in Extremadura; (b) developing partner and user relations, building on our existing links with central government, regional planning authorities, developers, landowners, lenders and consultants; (c) refining our assessment of feasibility in relation to the emerging legal framework in Spain. (3) To devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Detection, simulation, modelling and loading of thunderstorm outflows to design wind-safer and cost-efficient structures' to be submitted under Horizon 2020.

assistant: **Abstract**

Wind actions are crucial for the safety and cost of structures.The wind climate of Europe and many parts of the world is dominated by synoptic extra-tropical cyclones and mesoscale thunderstorm outflows. Thunderstorms are frequent events causing wind speeds often higher than cyclones.In spite of an impressive amount of research, there is not yet a model for thunderstorm outflows and their actions on structures like that for cyclones. Thus, thunderstorm actions on structures are still determined using the cyclone model developed half a century ago and engineering practice often leads to unsafe or too expensive construction.This happens because the complexity of thunderstorms makes it difficult to develop realistic and simple models. Their short duration and small size make the available data very poor. There is a great gap between research in wind engineering and atmospheric sciences.The realization of an unprecedented wind monitoring network, the role of the PI and his novel vision, a project team leader in wind engineering with interdisciplinary skill in atmospheric sciences, the chance to simulate large-scale thunderstorms in a new unique laboratory, the recent advance in CFD simulations, the success and synergy of previous and on-going projects, and a top host institution represent extraordinary conditions to overcome these shortcomings.THUNDERR is an acronym of THUNDERstorm that points out the ground-breaking Roar of this project. It aims to detect novel thunderstorm measurements, to create a huge dataset of field acquisitions and a new interpretation of their weather scenarios, to conduct unique wind tunnel tests and CFD analyses, to formulate a thunderstorm model that is physically correct and suitable to develop a loading scheme easily transferable to engineering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Application of peptide screening technology for identification of substrates of the Jumonji-C histone demethylases' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In recent years it has become evident that the functional human proteome is vastly expanded by post-translational modifications (PTMs)  that modify protein function and gene expression in a time- and context-dependent manner. Misregulation of these modifications leads to developmental disorders and often contributes to disease biogenesis. However, with the possible exception of protein phosphorylation, the full roles and regulation of these modifications remain poorly understood. Currently, in particular, arginine methylation is proposed to be largely stable and irreversible. Building on my exciting preliminary data that demonstrate that Jumonji C histone demethylases (JmjC KDMs) can catalyse removal of arginine methylation, this proposal aims to identify biologically relevant methylarginine substrates of the JmjC KDM. Cutting-edge mRNA display-based peptide screening technology will be adapted for use as a substrate identification assay in collaboration with Prof Hiroaki Suga at the University of Tokyo. Consensus sequences identified using this novel methodology will be used to identify biologically relevant peptide sequences by bioinformatic searches. On the return to the UK, results with isolated proteins will be correlated with in-cell studies and the functional consequences of these reactions assessed. Given the high level of interest in the post-translational modification field, the results of this study will be of interest to a very wide-range of scientists including other academic researchers in the field of epigenetics and beyond, and major biotechnology and pharmaceutical companies studying JmjC KDMs as drug targets. The fellowship will provide training in state-of-the-art techniques. The collaboration between the University of Oxford and the University of Tok
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Democracy-Migration Paradox: Anti-Immigrant Attitudes and Commitment to Democracy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The emerging paradox between widespread support for liberal democracy and rising anti-immigrant attitudes across Europe and the Middle East presents a critical challenge to democratic governance. This contradiction threatens core democratic values, as societies that advocate equal rights simultaneously adopt exclusionary attitudes. The Democracy-Migration Paradox (DEMIG) project investigates this complex relationship, exploring how negative attitudes toward immigrants can coexist with, and potentially undermine, democratic principles.DEMIG’s strength lies in its integration of frontier theoretical research and cutting-edge methodological innovation. Theoretically, DEMIG examines how anti-immigrant attitudes intersect with democratic values, exploring whether exclusionary attitudes lead to selective adherence to democratic principles, where citizens uphold ideals in theory but resist applying them to specific groups. This sheds light on the tension between democratic ideals and exclusionary practices, offering deeper insights into the ongoing crisis of democracy.Methodologically, DEMIG distinguishes itself through AI-assisted survey techniques and longitudinal surveys with embedded experiments to measure attitudes toward immigrants and democracy across diverse contexts. DEMIG will develop an AI model that generates precise, bias-resistant survey questions, advancing survey implementation and an experimental panel study. By minimizing social desirability bias and improving survey quality, DEMIG sets new standards in survey research, providing accurate measurements of how immigrant attitudes interact with democratic attachment.Insights from DEMIG will help policymakers craft inclusive migration policies, while its methodological breakthroughs will provide lasting resources
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of an Advanced Software Tool for Aircraft-level Investigation of the Impact of new Architectures for Avionics and On-board General Systems for the Green Regional Aircraft' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Under this proposal PACE GmbH will develop the required functionality using its leading knowledge-based engineering platform Pacelab Suite and the add-on module Pacelab APD for conceptual aircraft design. Both tools are well-established, industrialised products that offer an excellent basis for extension to consider novel, more electric architectures, and specifically the modelling of avionic and on-board general systems and their impact on the overall aircraft design. The resulting tool set will allow the ITD leaders to modell the system architectures in a graphic-interactive manner. Through the integration with Pacelab APD it will be possible to assess the impact on mass, center of gravity, power demand and cost. User-definable flight phases and failure modes will allow identification of the sizing conditions for the system components, the power plant and the overall aircraft structure. PACE GmbH is an SME that develops Knowledge Based Engineering (KBE) software solutions to the aerospace, automotive and transportation industries which enable its customers to better predict and plan the feasibility, performance as well as the economic and ecological viability of their products. PACE GmbH offers world-class IT technology in combination with excellent engineering skills that allow supporting its customers throughout the entire solution development process, from specification and development to maintenance and support. This proposal comprises twentythree (23) man months of development, project management and documentation, and fits into the overall budgetary frame of the project. The requirements as laid out in the Topic Description are fully met. Under the Implementation Agreement, PACE will supply the ITD leaders with licenses for the commercial products used as a basi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Turbine Aero Thermal External Flows' (TATEF), addressing dissemination and exploitation.

assistant: **Impact**

The overall objectives of the Turbine Aero-Thermal External Flows project are to understand the complex aero-thermal phenomena generated in turbines, to build the associated data bases and to facilitate the validation of improved Computational Fluid Dynamics (CFD) methods. This information is urgently needed for aero-engine and gas turbine companies to improve turbine performance, life and weight and therefore to maintain or increase their competitiveness.The work programme has been sub-divided in four complementary tasks which form all together a project dealing with the most important turbine external aero-thermal aspects:- Temperature distortion and interaction effects in turbines;- Aero-thermal performance of HP turbines;- Fundamental film cooling studies;- CFD calculations.Therefore, 3D detailed experimental studies of unsteady aerodynamics and heat transfer in three full scale 1.5 stage turbines will include the investigations of: the temperature distortion at the turbine entry, the aerodynamic clocking effect, the performance of different types of cooling and the aerodynamic operation of HP/IP and HP/LP interfaces. In parallel to these 3D investigations, some fundamental film cooling studies will be carried out.Finally, advanced CFD methods as well as industrial tools will also be developed, adapted and tested against the experimental results. All these activities take benefit from previous works performed and facilities developed in the European framework. Nearly all the European aircraft engine manufacturers, two important gas turbine producers and the best available research centres and universities in the turbine domain, are involved in the project to form an European platform being able to carry out the work programme BE97-4440.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European mouse mutant archive network (EMMANET)' in the context of a Fifth Framework call.

assistant: **Objectives**

The European scientific community is internationally competitive in producing and characterisation of mouse models for inherited diseases. It is essential that all mutants that are created are retained and held in a well-organised central repository-network from which they can readily be made available to interested investigators. To meet these needs the European Mouse Mutant Archive was established and implemented. EMMA is running under highest quality standards and was opened to the public in 1999. Since new partners joined this European enterprise it is now the time for reconstruction in terms of co-ordination and networking. With the help of EMMA net a director will be implemented responsible for co-ordination and set up of SOPs for every EMMA procedure. This will ensure the accessibility for scientific community and industry. EMMA net will be essential to develope EMMA towards a virtual repository appearing as one centre.