RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Policies to extend working life: implications for gender, ageing and precarious work.' in the context of a Seventh Framework call.

assistant: **Objectives**

The proposed project is a cross-national comparative qualitative analysis of the impact on older workers in Ireland and the United States of policies introduced to extend working lives; it will focus on gender, precarious work, health and the impact of the global recession. Demographic ageing poses a formidable policy challenge for governments in western countries and will do so for the foreseeable future (OECD, 2012). There is a need for increased pension provision as workers live longer after retirement. This has major implications for budget allocation and labour market policies. In response to this, governments, including Ireland and the U.S. have moved, rather swiftly, to introduce new policies designed to extend working life, such as increasing state pension age, and allowing flexibility to work beyond retirement age. However, the consequences of such change for individuals are not well understood. To inform the policy process, several kinds of unanswered questions regarding the implications of such policies for peoples’ lives urgently need to be addressed. This project proposes to investigate the experiences, decision-making and outcomes for older workers in Ireland and the United States, in relation to recently-introduced policies designed to extend people’s working lives. This study will use an innovative lifecourse methodology to compare the experiences of workers around retirement age in the U.S. and Ireland, using interviews with 120 men and women (60 per country). A special feature of this project is its internationally comparative dimension, through which the experiences of Irish and American older workers will be compared
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Automatic Performance Analysis: Real Tools' (APART2) targeting Fifth Framework.

assistant: **Abstract**

The working group APART2 will network national European development projects working on automatic performance analysis tools. These projects are based on the results of the Esprit Working Group APART 1 (Project No. 29488) on Automatic Performance Analysis, which was being funded until December 2000. APART 2 will extend the specification techniques developed in APART 1 and will investigate a broad range of implementation technologies. Besides collaboration among the national projects, the working group will investigate requirements and techniques for performance analysis in grid environments. The European and American partners of this working group will closely collaborate to disseminate and collect information on automatic performance analysis tools. Three international workshops will be held in the style of the successful APART 1 workshops. The working group APART2 will network national European development projects working on automatic performance analysis tools. These projects are based on the results of the Esprit Working Group APART 1 (Project No. 29488) on Automatic Performance Analysis, which was being funded until December 2000. APART 2 will extend the specification techniques developed in APART 1 and will investigate a broad range of implementation technologies. Besides collaboration among the national projects, the working group will investigate requirements and techniques for performance analysis in grid environments. The European and American partners of this working group will closely collaborate to disseminate and collect information on automatic performance analysis tools. Three international workshops will be held in the style of the successful APART 1 workshops.OBJECTIVESThe goals of the working group APART 2 (Automatic Performance Analysis: Real Tools)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Logistic Efficiencies And Naval architecture for Wind Installations with Novel Developments' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

A new EU 7th Framework Programme project, “LEANWIND” (Logistic Efficiencies And Naval architecture for Wind Installations with Novel Developments) seeks to apply lean principles to the offshore wind farm project lifecycle. The primary LEANWIND objective is to provide cost reductions across the offshore wind farm lifecycle and supply chain through the application of lean principles and the development of state of the art technologies and tools.The offshore wind industry in existing near shore shallow sites has yet to become cost competitive with traditional forms of energy while new sites are being planned for greater distances from shore or deeper water bringing new challenges. The offshore wind industry has not yet applied lean principles to the logistical operations of the wind farm in all stages of the lifecycle as proposed by the LEANWIND project. “Lean” principles were originally developed by Toyota to optimise the processes of manufacturing industries; these principles of optimisation and efficiency have subsequently been adopted by many other industries to remove wasteful stages and streamline processes.This new “lean” paradigm will be applied to each of the critical project stages: logistical processes, shore-based transport links, port and staging facilities, vessels, lifting equipment, safety and O&M.The LEANWIND approach will ensure that unnecessarily complex or wasteful stages of the development process are removed, flow between the required stages is streamlined, quality is enhanced and thus overall cost and time efficiency improved to enable the industry to bridge the gap between current costs and industry cost aspirations. Properly applied, lean management will improve quality, reliability and H&S standards across the project supply chain and throughout t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Operational model order reduction for nanoscale IC Electronics'.

assistant: **Concept**

The project aims at developing methods capable of reducing simulation time. The common denominator in these methods is the creation of a model of the Integrated Circuit (IC) behaviour, in which the model behaviour is less complex than the complete behaviour of the IC itself, but in which the essential characteristics of IC behaviour have been preserved. Such methods are Behavioural Model Order Reduction (BMOR) methods, Model Order Reduction (MOR) methods and Response Surface Modelling (RSM) methods. Behavioural simulation with the models created with these methods is much less computation intensive than simulation of the complete IC behaviour. This enables the simulation of complete systems that otherwise would be impossible to simulate. Developing the above mentioned model reduction methods, requires knowledge that currently is scattered over many sites in Europe. Much algorithmic knowledge exists at universities, much of the application knowledge however is present in industry. The combination of the two types of knowledge is essential to come to algorithms that are suited for industrial use. This is the key aspect of the project: it facilitates the exchange of knowledge between the industrial partner Philips (PHI) and three academic partners renowned for their competence in model reduction methods. These partners are Chemnitz University of Technology (TUC), University of Antwerp (UNA) and Eindhoven University of Technology (TUE), with their respective competences in MOR-, RSM- and BMOR methods. The project creates a multiple win-win situation: the industrial partner can improve its competitive position, while the academic partners can rise to a level that meets international standards. The research carried out in the project is the basis for innovation, that allows t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Recombinational DNA repair analyzed by simultaneous scanning force and single molecule fluorescence microscopy: role of RAD54 in presynaptic and postsynaptic events'.

assistant: **Concept**

The goal of the research is to understand the mechanistic of human genetic recombination at the single molecular level.Homologous recombination, the exchange of sequences between homologous DNA molecules, is essential for accurate genome duplication, DNA damage repair and chromosome segregation. Single molecule analysis provides information on intermediate states, functional and structural variability and the distribution of variable states that cannot be recovered from bulk biochemical assays.Understanding the mechanism of DNA repair by homologous recombination requires detailed structural descriptions of recombination intermediates.We are uniquely poised to unravel key steps in homologous recombination at the molecular mechanistic level using state of the art imaging tools. We have a substantial track record in applying SFM topographic imaging to the understanding of DNA break repair mechanisms and other genome transactions. The recently developed method that combined SFM with single molecule sensitivity fluorescence will expand the information we can obtain from molecular imaging. In particular, our aims will be:1 Simultaneous localization of multiple human DNA repair factors acting on recombination intermediates.2 Analysis of DNA replication after repair.Homologous recombination proteins are the target for important treatment modalities against cancer. By analysing the mechanism through which these proteins cooperate in DSB repair, we expect to provide insights into their molecular assembly.Recombination proteins and DNA substrates labelled with flourophores will be used in single molecule microscopy assays. We have developed methods to combine SFM nm resolution topography and single molecule sensitivity fluorescence (Sanchez, et al., 2010). This SFM-fluorescence mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Actinide User Laboratory' to be submitted under Sixth Framework.

assistant: **Abstract**

The actinides are a unique set of elements. This uniqueness stems not only from their nuclear properties, which have led from the 1940's on to their important role in nuclear energy and nuclear technology, but also from their unusual chemical and physical properties, which have added new excitements and discoveries to both these disciplinesUnconventional strongly correlated electron phenomena and various possible oxidation states, offering a wide variety of chemical reactions, are coming from the unusual behaviour of their 5f electrons - which causes questions such as localisation and delocalisation to come to the forefront and adds complexity not found in the other elements.Ongoing efforts, both experimental and theoretical, include not only a deeper understanding of these unique elements but of the rest of the elements in the Periodic Table as well. However, despite the scientific importance of this endeavour, both from the fundamental point of view and its relevance to issues related to nuclear power generation, waste treatment, and disposal, the knowledge base is seriously at risk.The radioactivity of all materials beyond uranium (and today even for uranium) means that special handling facilities are required. These are expensive to build and maintain, and their number, especially in the universities, is decreasing. Thus, overall capabilities for research are decreasing.The present proposal is aimed to augment our knowledge of actinide materials by opening the Institute for Trans-uranium Elements' basic research facilities to European and Associated Countries researchers by sustaining a User Lab".Our laboratory is unique in Europe in having facilities capable of handling radioactive isotopes greater than microgram quantities extending over a wide range of chemical a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enabling the WHO-Roadmap 2030' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

We will establish for the first time in NTDs an adaptive clinical trial platform and improve clinical research infrastructure in four SSA countries. A drug acting safely on multiple helminths species would be a major leap to tackle NTDs and enable the WHO RoadMap (eWHORM). The cheap and freely-accessible pan-nematode drug oxfendazole (OXF) has such potential. Given the limited portfolio of anthelmintic drug candidates, eWHORM will assess its efficacy in an adaptive clinical trial for simultaneous evaluation against onchocerciasis, loiasis, mansonellosis and trichuriasis. Thus not only the largest group of NTDs, but also diseases that are not (yet) listed will be adressed. This design significantly reduces patient numbers, development time-frames and enables treatment of co-infections. Combined with our highly sensitive molecular tests, we provide a patient-centric approach providing tools for targeted treatment (test and treat) and precision mapping for elimination programs. Strengthening of early career scientists in SSA in all aspects of clinical trial conduct and research including data management, simulation and statistical analysis, will be fostered by introducing a master and PhD program, a mentorship program as well as several webinars. An open-source virtual training and assessment tool for diagnosis of NTDs will complement the knowledge transfer to remote areas in SSA. The consortium encompasses an interdisciplinary partnership from eight different countries (Germany, the Netherlands, Austria, Switzerland, Cameroon, Gabon, Tanzania, and DRC). Each group brings unique knowhow and recognized complementary experience to the project to ensure sustainable capacity building within SSA countries. Through joint development of – and training in – modern, regulatory clin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Cloning and characterisation of factors interacting with the yeast essentialsnorna snr30'.

assistant: **Objectives**

In this project we intend to further characterise the structure and function of the snoRNP (small nucleolar ribonucleoparticle) snR30. This particle, made of the essential snoRNA (small nucleolar RNA) snR30 and several nucleolar proteins, has been shown to be required for the ribosomal processing reactions which lead to the formation of the mature 18S rRNA, the RNA component of the small ribosomal subunit. We propose to identify new genes whose products either interact or have overlapping functions with the snoRNA snR30. This will be achieved through the isolation of multicopy and extragenic suppressors of snr30 conditional mutations, as well as the identification of synthetic lethal mutations. This screening should allow the identification of proteins associated with the snR30 RNP particle, as well as interactions between different snoRNP particles. This will provide a test of current hypotheses for mechanisms involved in pre-rRNA processing in yeast.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Design of novel inhibitors of hcv rna helicase - potential antivirals for treatment and protection against hepatitis c virus-induced diseases (HCV INHIBITORS)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Hepatitis C virus (HCV) infections lead to liver cirrhosis and hepatocellular carcinoma. Currently no efficient drug or vaccine is available. A team of 6 European laboratories from D, F, PL will synthesise and investigate the psycho-chemical and biological properties of a broad range of new modified nucleoside derivatives, guanine, trampoline and anthracycline analogy and their prod rugs, potential inhibitors of HCV RNA helices, a novel and promising target for anti- HCV therapy. The interactions of analogy with HCV helices will be investigated with the use of kinetic methods, crystallography, and multidimensional NMR and CD spectroscopy. Inhibitory activity against HCV helices will be verified in vitro in HCV-infected human macrophages, in human hepatocytes and in yeast cell system. This research should deliver new anti-HCV drugs and may improve the quality of life of millions of HCV-infected patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Investigating how anaphase chromosomal motion is generated during mitosis and meiosis'.

assistant: **Concept**

Cell division is a process essential for life. There are two types of cell division: meiosis and mitosis. Meiosis is a type of cell division specific to germ cells, allowing the formation of fertilisation-competent sperm and eggs. Mitosis allows a single-celled fertilised egg to develop into a mature organism, and also allows tissues to be renewed. During each cell division, the cell must divide two copies of the genome equally between two daughter cells. Errors that occur during this process in oocytes can lead to spontaneous abortion and birth defects, whilst errors occurring in somatic cells can lead to genetic instability, a hallmark of cancer. It is therefore essential to understand how this fundamental process occurs. The phase of cell division during which the chromosomes are physically separated is called anaphase. Although anaphase has been studied for more than a century, the mechanisms that underlie the poleward movement of chromosomes in mammals are still unclear. Several studies have suggested candidate proteins that may power their movement, but there were no conclusive results due to the technically challenging nature of this research. The main challenge is that one must efficiently inactivate the candidate protein(s) only at the onset of anaphase so as to avoid disrupting the previous phases of cell division, which could confound the results. Methods to rapidly inactivate proteins targets have only recently become available. Here, we propose to use these techniques to study the mechanism(s) underlying poleward chromosome movement during anaphase in both meiosis (mouse oocytes) and mitosis (non-transformed mammalian somatic cells). In both cases, we will validate the results using a combination of loss-of-function and optogenetics tools, high-resolution l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'International Innovation Network for the Development of Cost- and Environmentally Efficient Seasonal Thermal Energy Storages' (INTERSTORES) targeting Horizon Europe.

assistant: **Abstract**

Future energy systems will integrate diverse, variable renewable energy sources to replace fossil fuels, use sector coupling and waste heat recovery, and interact symbiotically with a variety of users. Seasonal thermal energy storages (sTES) are existential for peak-shaving and load-shifting in these systems and they increase the usability of decentrally generated thermal energy. INTERSTORES aims to achieve successful market acceptance, technological attractiveness and competitiveness by improving performance, cost efficiency and increased reliability. By pooling engineering, (hydro-)geological, environmental, and applied disciplines as well as expertise from different sectors, 14 partners from 9 countries will ensure a high exploitability through technology transfer measures.For this, INTERSTORES promotes the full-scale realization of two different sTES variants. Two demonstrators address one crucial concept of versatile sTES solutions in European’s future energy systems: The combination of several tuneable sTES.Overarching goal is proving the international market potential of novel Reno-sTES and Giga-CTES by demonstration of highly favourable techno-economic and environmental performance. With the unique opportunity of full-scale demonstration, INTERSTORES’ innovations will close critical gaps for arriving at reliable facilites, robust operational functioning and replicable implementation. The two solutions will reveal crucial differences regarding optimal design, integration potential on different scales, operating conditions, costs, environmental impacts and benefits. Finally, INTERSTORES will not only demonstrate application of planned innovation modules for sTES to project’s demo sites, but set a major focus on maximizing their replication potential. This will be