RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Engineering a Sugar-targeted Nucleic Acid delivery Polymer to understand and enhance vaccination by self-amplifying RNA' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

I aim to expand the broad clinical potential of  self-amplifying RNA (saRNA) vaccines by crafting nanomaterial formulations that will target intracellular delivery of saRNA and molecular adjuvants to the key cells that mediate immunity. Both the devastating SARS-CoV-2 pandemic and annual flu seasons expose a significant need for more rapid development of effective vaccines. Nucleic acids such as self-amplifying messenger RNA (saRNA) are an exciting new class of subunit vaccine cargoes that promise to address the need for more adaptable, scalable, and more efficacious vaccines in comparison to those rooted in laboriously produced recombinant proteins.  Although saRNA-based vaccine production offers a powerful platform to address these major issues with vaccine development, there is a huge need for innovative methods that can deliver nucleic acids across the body's many physiological barriers and generate protective immunity. This project seeks to apply the materials expertise of the applicant and the Stevens group (Imperial College London [ICL]) to the improved delivery and function of first generation saRNA vaccines that have been pioneered in the Shattock group (ICL).  We hypothesize that polymer nanomaterial design can enable delivery of saRNA vaccine components to key cells responsible for generating adaptive immune responses and that this ""targeted"" saRNA vaccine delivery will lead to enhanced protective immunity compared to current vaccines.  I will apply advanced polymerization techniques to tailor the delivery of saRNA to antigen presenting cells and to master cutting-edge imaging techniques to characterize the cellular response to targeted vaccine uptake (Raman, FIB-SEM). I will then collaborate with the Shattock lab to evaluate vaccine targeting in mice in vi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Rheology and Mechanics of Active Glasses' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The mechanics and flow behaviour of living or active matter is key to biological processes like wound healing or cancer metastasis, but today there is very limited understanding of what governs the mechanical properties of such dense active systems. The proposed project will harness tools from the Statistical Physics of Glasses to provide new fundamental insights into Active Matter mechanics and rheology. This will not only help understand the deformation and flow of living glassy systems but also pave the way to the creation of designer active materials. The project will use particle-based simulations of model active glasses to construct a detailed phenomenology of their behaviour for a broad range of deformation scenarios including steady shear, shear startup and oscillatory shear. The insights from this will be condensed into a mesoscopic model that extends and builds on the very successful Soft Glassy Rheology (SGR) model, by incorporating essential biophysical ingredients and in particular the driving by active processes. This mesoscopic approach will allow scaling up to realistic system sizes and will identify the key parameters that need to be tuned in the design of new active materials. The insights gained on a wide range of systems from the cytoplasm and cellular aggregates to synthetic active matter will have a strong impact both on the academic and, in the medium term, non-academic sectors. They will reach across traditional boundaries to researchers in physics, biology and chemistry and strengthen an important interdisciplinary field within the European Research Area. The outreach opportunities provided by the fascinating behaviour of active glassy materials will be exploited with dedicated dissemination and communication activities targeted at a broad range
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Promoting sustainable patient treatment by an intelligent online medicine dispenser for home care use.'.

assistant: **Innovation**

THE BUSINESS CONCEPT: 8% of total healthcare expenditure or about 500bn USD per year globally, can be avoided with optimized use of medicines (IMS Health).  eMediCare is a online medicine dispenser for home care use that connects the person taking the medication directly to the distributor and prescriber (GP).  This challenges and disrupt the current suboptimal medication delivery from nurses or pharmacies, eMedicare offers a secure and monitored logistics chain of drug delivery where the prescriber (GP) frequently adjust the dosage to the appropriate level.THE SOLUTION:This ICT driven disruptive business model and product innovation will reduce the amount of medicines prescribed, dispensed or sold inappropriately. We base the project on a existing cloud ICT infrastructure where the intelligent online medicine dispenser eMediCare will eliminate error sources and secure that patients take medicines correctly at right time. THE USERS: eMediCare is intended for home care use and build a strong link but at the same time disrupt the current interplay between the health-care provider, the patient and the pharma companies producing and distributing the medication. THE PROJECT: The phase 1 of the project is devoted to establishing business model and deliver a business plan for the key market Scandinavia and UK. The phase two of the project will pilot and further refine the business model and systems engineering design of the eMediCare and create a working prototype to be implemented in test cases in the key markets. THE MARKET: The EU market for pre packed medication, online medication distribution with the supporting ICT/telehealth solution is estimated to 2.5B bill EUR/year that will result in a 25 bill EUR/year in healthcare cost reduction. THE EU DIMENTION: The success of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unified eLearning Environment for the school' under Sixth Framework.

assistant: **Concept**

The evolution of schools from teaching institutions towards community centres for learning raises a number of pedagogical and social challenges. Learning is no longer confined to the traditional teacher-pupil relationship but learner-cantered, personalized learning approaches are being implemented and the effectiveness of collaborative learning is now generally recognized. This evolution of schools takes place at various paces throughout the enlarged European Union.Technology can be an important enabler of this evolution. However, in order to be accepted by all the actors, the technology must be flexible and adaptable to the specific learning contexts (situations and environments) of each school rather than imposing a common model upon all schools.The objectives of UNITE are in the areas of both ICT as well as education:- In the area of ICT, the conceptualization, design, and development of a very comprehensive, highly modular eLearning and communication platform, supporting the development, management and re-use of learning objects, activities and experiences, and appropriately linking up the mobile phone technology for learning purposes, an area still very challenging for learning environments.- In the area of education, the design of innovative pedagogical methods enhanced by this ICT platform to be used and validated in a variety of different types of schools. These new pedagogical approaches will be applicable to all schools, taking into account the diverse cultural and educational backgrounds.The project will also study in depth issues about 'accessibility for all' and good practices in context-specific learning design, to enhance the learning experience and to ensure that learners are empowered and motivated to learn in this manner.UNITE will greatly contribute t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Effects of emotion and stress on different memory phases' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Where were you when you heard about the terrorist attack on the world trade center? Can you remember receiving your high school diploma, your first kiss? Very likely you are able to remember these emotional events. Emotions have a profound impact on what we learn and keep in mind and thus influence who we are. In particular, emotions affect various stages of memory, i.e. encoding, consolidation, retrieval, and reconsolidation. Stress hormones, i.e. glucocorticoids as well as catecholamines released upon an emotionally arousing experience influence emotion’s effects on all stages of memory formation. The major aim of my research is to characterize the behavioural and neurobiological processes that underlie the effects of emotion and stress on different memory stages. To study this topic, I use human experimentation combining behavioural studies, pharmacological manipulations and neuroimaging techniques. Using these various approaches, I am creating a research framework that integrates the cognitive and affective level with the underlying neurobiological mechanisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'AI Driven industrial Equipment product life cycle boosting Agility, Sustainability and resilience' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Machinery industry in Europe is a basis for employment, growth and wealth, with around 3.2 million people employed. Industrial equipment is considered a key enabler for industrial development and the EU has a historically strategic position in this sector. However, it lives from a technological edge in a very competitive landscape. Hereby, it is crucial to provide all stakeholders of the EU with AI technologies that guarantee a resilient design, deployment and reuse of industrial equipment for an increased global competitiveness and a reinforcement of its industrial strategic autonomy and resiliency.AIDEAS will develop AI technologies for supporting the entire lifecycle (design, manufacturing, use, and repair/reuse/recycle) of industrial equipment as a strategic instrument to improve sustainability, agility and resilience of the European machinery manufacturing companies. AIDEAS will deploy 4 integrated Suites: 1) Design: AI technologies, integrated with CAD/CAM/CAE systems, for optimising the design of industrial equipment structural components, mechanisms and control components; 2) Manufacturing: AI technologies for industrial equipment purchased components selection and procurement, manufactured parts processes optimisation, operations sequencing, quality control and customisation; 3) Use: AI technologies with added value for the industrial equipment user, providing enhanced support for installation and initial calibration, production, quality assurance and predictive maintenance for working on optimal conditions; 4) Repair-Reuse-Recycle: AI technologies for extending the useful life of machines through prescriptive maintenance (repair), facilitating a second life for machines through a smart retrofitting (reuse) and identification of the most sustainable end-of-life
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Regulation of immune responses and autoimmunity by activating and inhibitory NK receptors expressed by T lymphocytes: role of ITAM versus ITIM signal balance' (LY49-AUTOIMMUNITY).

assistant: **Innovation**

Immune cell activity is regulated by both activating and inhibitory receptors, which transduce signals through two motifs: ITAM and ITIM, respectively. ITIM receptors play a key role in the regulation of ITAM induced activation of leukocytes, thus creating a balance, which regulates cellular functions and the outcome of the immune response (immune priming or tolerance).Moreover aberrant expression of activating and/or inhibitory immune receptors and of their ligands can lead to deleterious effects, including autoimmunity. While inhibitory NK receptors are also often expressed by normal T cells, the activating counterparts are mostly found on pathogenic self reactive T cells in autoimmune diseases.Transgenic mice expressing activating receptor Ly49D/DAP12 an d/or its inhibitory counterpart Ly49A (in presence/absence of H 2Dd as ligand) offer the opportunity to better understand the role of ITAM/ITIM balance in T cell biology, and the relevance of T cell ITAM signalling (via DAP12) in autoimmunity.We first pro pose to address T lymphocyte differentiation in Ly49D/DAP12 transgenic mice, by studying thymocyte development and TCR repertoire selection. Peripheral T lymphocyte function will be investigated upon Ly49D engagement alone or in combination with TCR stimulation.With the aim to assess the function of activating receptors expressed by CD8+ T cells in autoimmunity, a model of diabetes will be used (RIP-LCMV mice). The CD8+ T cells of the Ly49D/DAP12 transgenic mice will be will be transferred into RIP LCMV G P transgenic mice, whose beta islet cells express LCMV GP (lymphocytic choriomeningitis glycoprotein) as self antigen.In this model, self-reactive CD8+ T cells trigger diabetes only upon adequate stimulation (e.g. LMCV infection, CD28/B7.2 costimulation). We will t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Mass, heat and spin transport in interlinked quantum gases'.

assistant: **Objectives**

The objective of the proposed project is to create a versatile experimental and methodological platform for exploring transport mechanisms with quantum gases. Our approach will enable studying the dynamics of mass, heat and spin transport between linked reservoirs with a unique degree of control and flexibility, and promises to open up a route to discovering yet-unknown transport phenomena.Over the past two decades, ultracold atomic quantum gases have taken an increasingly lively role in the endeavour to understand quantum many-body systems, offering insights into a wide range of quantum phases and transitions between them. Recently, the approach has proven its potential to take us beyond the simulation of existing concepts and to provide a platform for probing the physics of quantum many-body systems in novel contexts. In particular, we have shown that measurements of directed transport through channels connecting atomic reservoirs not only emulate scenarios known form electronic transport in solid-state systems, but can test new experimental situations and give rise to new questions.We now propose to establish a general quantum-gas platform for exploring a wide range of configurations for transport measurements. Specifically, we will study the non-equilibrium dynamics in systems consisting of connected fermionic quantum-gas nodes, which serve as particle reservoirs of different size, shape and dimensionality that can be individually initialized and coupled to one another using configurable links. Time-dependent drive or controlled dissipation can be applied to the nodes and links. Using such networks, we will study transport between reservoirs of different nature, probe superfluid samples with controlled particle currents, characterize transport processes at the inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Evolving communication systems in response to altered sensory environments'.

assistant: **Innovation**

How animal communication systems evolve is a fundamental question in ecology and evolution and crucial for our understanding of adaptation and speciation. I will make use of the process of urbanization to address how communication signals adapt to changes in the sensory environment. I will focus on the impact of noise and light pollution on acoustic communication of Neotropical frogs and address the following questions:1) How do senders, such as a male frog, adjust their signals to altered sensory environments? I will assess plasticity and heritability of signal divergence found between urban and forest populations of the tungara frog. 2) How do signals evolve in response to direct (via sender) and indirect (via receivers) selection pressures? I will expose forest sites to noise and light pollution, parse out importance of multiple selection pressures and carry out experimental evolution using artificial phenotypes.3) What are the evolutionary consequences of signal divergence? I will assess inter-and-intra sexual responses to signal divergence between urban and forest populations. 4) Can we predict how species adapt their signals to the sensory environment? I will use a trait-based comparative approach to study signal divergence among closely related species with known urban populations. Our state-of-the-art automated sender-receiver system allows for experimental evolution using long-lived species and opens new ways to study selection pressures operating on animal behaviour under real field conditions. Our expected results will provide crucial insight into the early stages of signal divergence that may ultimately lead to reproductive isolation and speciation.


**Keywords:** signal evolution,  urbanization,  sensory pollution,  anthropogenic noise,  artificial light
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Baculovirus surface display - development and applications' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

This project aims to develop a system for the display of complex eukaryotic proteins on the surface of insect baculovirus particles, thus complementing the powerful bacterial phage display" technology which is already so successful. This latter system was developed to isolate specific ligands from pools of different binding proteins expressed on the viral surface as fusion proteins with a phage coat protein. This approach, however, has severe limitations when the proteins under study are large complex, eukaryotic proteins that cannot be processed correctly in a bacterial expression system. Surface display has been performed in eukaryotic cells via the use of yeast, retroviral vectors and plant viruses but a system of comparable power to the bacteriophage has yet to be developed. The insect baculovirus, Autographa californica nuclear polyhedrosis virus (AcMNPV), is utilized for the expression of recombinant proteins. The virus has a single major envelope glycoprotein, gp64. As a prominent surface projection, gp64 has recently been shown to be suitable for the display of foreign proteins on the baculovirus surface. Moreover, AcMNPV can accommodate large DNA insertions and grow to high titre, making it satisfactory for the generation of display libraries representing a variety of large proteins such as surface receptors, viral glycoproteins, ion channels, and enzyme complexes in a stable and functional form. Before this goal can be realized, however, further research needs to be done to understand the basis of fusion protein pick-up on the virus surface and to improve the technology for recombinant formation to enable the construction of complex libraries. This application addressed these needs with the following specific objectives: - To determine the three dimensional st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Innovative firm's performances and internal/external workforce flexibility and personnal/social consequences'.

assistant: **Concept**

A consortium of 11 European institutes including 7 countries proposes to undertake a study on the links between work organisation and performance including social dimension.European SMEs are highly exposed to more and more concentred and fierce competition. At first glance, continuous innovation, developing and sharing new technologies, increased productivity seems to be adequate solutions. We think that the real source of Europe's competitive advantage lies in its capacity to do think differently, in a way that cannot be easily imitated by our competitors. The SMEs potential is not strong enough individually to face this substantial and structural change. It seems vital to build a public and European sphere of knowledge where a new common learning amongst employers, employees and social partners can take place. This network to build will also include policy makers.