RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project '5G+ evoluTion to mutioRbitAl multibaNd neTwORks' (TRANTOR) under Horizon Europe.

assistant: **Objectives**

5G mobile networks will be soon fully available, handling all types of applications and providing services to massive number of users. In this complex and dynamic network ecosystem, an optimized end-to-end satellite support is key to manage requirements imposed by multiple vertical industries requiring full global connectivity. The European space sector acknowledged this as a key opportunity to expand its business towards the massive deployment of broadband services, what resulted in standardization efforts to adapt 5G to satellite needs. In this context, the aim of TRANTOR is to perform a significant step forward by paving the path for the 5G NTN evolution towards 6G. To do so, TRANTOR targets the in-orbit validation of a complete satellite value chain involving an automated management of satellite resources across multiple bands, satellites, and orbits, and a converged radio access network. Specifically, at the ground segment, TRANTOR targets the development of novel satellite network management solutions, fully integrated in the 3GPP management framework, which allow the significant scaling up of heterogeneous satellite traffic demands and capacities in a cost-effective, highly dynamic, band and orbit agnostic manner. AI governance will be a main pillar here enabling real time radio resource management across multiple satellite systems for efficiently and trustworthy addressing satellite client needs. In parallel, in the user segment, TRANTOR aims to radically increase the flexibility of access architecture by enabling pre-6G non-terrestrial multi-connectivity. It will be supported by the design of a multi-orbit and multi-band antenna for satellite UEs as well as by the development of gNB and UE 5G NTN equipment able to attend the multi-connectivity needs. Finally, T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Reactivation of the Fanconi anemia-BRCA pathway in cells carrying patient-derived missense mutations: finding a drug to cure Fanconi anemia' (FANCODRUG), addressing dissemination and exploitation.

assistant: **Impact**

Fanconi anemia (FA) is a genetic disease characterized by bone marrow failure, malformations and cancer predisposition. Currently, there is no cure for FA and life expectancy is 29 years. In addition, FA cells are hypersensitive to DNA coss-linking agents used in chemotherapy making cancer treatment difficult. The genetic cause of FA is heterogeneous, involving at least 19 different FA genes (FANCA, B, C, D1/BRCA2, D2, E, F, G, I, J, L, M, N, O, P, Q, R, S/BRCA1 and T) all interacting in a common DNA repair pathway (the FA/BRCA pathway). FANCD2 ubiquitination and localization at sites of DNA damage is a key step in the activation of the FA pathway and it is used to assess its functionality. Importantly, mutations in FANCA are the most prevalent, accounting for 60-85% of FA cases. FANCA missense mutants mislocalize FANCA to the cytoplasm instead of the nucleus, thereby inactivating the FA pathway. However, FANCA mutants may retain its functionality, suggesting that correction of the subcellular mislocalization of FANCA missense mutants may be an effective way to reactivate the FA/BRCA pathway in these patients. In this application, we propose to conduct a study to develop a system to promote nuclear localization of FANCA missense mutants and evaluate its impact on the activation of the FA/BRCA pathway. This study will yield valuable information about the molecular mechanisms that determine FANCA subcellular localization and pathogenicity of the mutations. In a second part of the project, we will use an unbiased high-throughput approach to screen for drugs that can reactivate the FA/BRCA pathway in cells containing FANCA missense mutations, independently of their mechanism of action. In summary, using a combination of targeted and unbiased approaches, we aim at finding th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Extreme Precipitation Response to Temperature Variations: The Role of Storm Types and Global Circulation Patterns'.

assistant: **Objectives**

Extreme precipitation-related disasters are causing serious concern to our society. Especially over the last few years, their intensity and frequency have become substantial throughout the globe, a trend that is projected to continue in the coming decades. While existing studies indicate that extreme precipitation increases with temperature—a phenomenon known as scaling—the exact rates of this increase are not spatially homogeneous, and global distribution remains highly debated. Furthermore, current literature has only considered temperature, with no studies examining how different storm types and global circulation patterns could affect this scaling rate, especially at the global level. Since extreme precipitation results from complex phenomena and depends on multiple factors, accurately forecasting and predicting these events is extremely challenging. This, in turn, hampers early warming, efficient mitigation, and strategic planning for such future events. Addressing these research gaps, the PTSTORM project introduces a novel approach to estimating how storm types and global circulation patterns can modulate the scaling of extremes. The project is interdisciplinary in nature and incorporates a range of datasets from satellites, reanalysis, and observations. The project will have significant societal impacts as it will play a pivotal role in providing a broader understanding of the physical mechanism behind the extremes and, consequently, preparing mitigation plans accordingly. Furthermore, it is in line with the EU strategy for the sustainable development goal 13 'Climate action' and thus contributes to the enhancement of EU scientific excellence. Moreover, the project will enhance the researcher's career growth, expand his knowledge and expertise in the field of atm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'microRNA replacement therapy for mature B cell neoplasias'.

assistant: **Innovation**

Mature B cell neoplasias include most of Non-Hodgkin Lymphomas (NHL), such as Diffuse Large B Cell Lymphomas and Burkitt Lymphoma and also B cell Chronic Lymphocytic Leukemia. It is estimated that about 60000-80000 new cases of mature B cell neoplasias are diagnosed every year in Europe. About 60% of NHL present with aggressive forms, and need immediate therapeutic action. The most common choice of treatment for mature B cell neoplasia is chemotherapy, and particularly the multidrug R-CHOP, but a fraction of the cancers either are refractory to these therapeutic interventions or relapse after treatment. Indeed, NHL is the cause of close to 26,000 deaths per year in Europe. Therefore, alternative therapeutic targets are imperative to replace or complement the current approaches.microRNAs (miRNAs) have arisen as extremely promising therapeutic tools in a number of diseases, including cancer. We have identified a miRNA specific of mature B cells whose expression is lost in mature B cell neoplasias. We found that re-introducing this miRNA in lymphoma cells in animal xenograft models leads to a dramatic block of tumor growth and extends mouse survival. Our studies show that this miRNA is therapeutically efficient not only in the form of lentiviral vectors but also as a synthetic miRNA mimic. Likewise, both intratumoral and systemic, intravenous delivery of miRNA mimic have yielded positive regression results. In addition, established lymphoma cell lines as well as primary mature B cell lymphomas have proved sensitive to miRNA treatment.Therefore, we propose to take to proof of concept the idea that miRNA replacement is an efficient therapeutic strategy for the treatment of mature B cell lymphomas. With this HEAL-BY-MIRNA proposal we aim at moving forward this idea to a stage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Norsepower Rotor Sail Solution demonstration project' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The Norsepower Rotor Sail Solution enhances the complete propulsion system of a vessel by using wind as an auxiliary propulsion measure. The patented turnkey solution, which is based on the Magnus effect, offers auxiliary wind propulsion for freight vessels, requires no additional crew to operate the Rotor Sails, and is suitable for retrofitting to over 20 000 vessels in the global merchant fleet. The system enhances energy efficiency, and reduces emissions and pollution. Norsepower Rotor Sails are developed to be an affordable off-the-shelf product to be retrofitted into existing vessels or installed into new-build vessels.According to Norsepower’s commercialization plan, a successful full-scale demonstration of the Norsepower Rotor Sail Solution would enable realizing large-scale deployment and manufacturing ramp-up of the technology in relatively short period.The main objective of the RotorDEMO project is implementation of Norsepower Rotor Sail Solution in full scale on a RoPax vessel to boost sales of the solution. Other objectives are performance validation and type approval of the technology and update of Norsepower’s commercialization plan based on the findings. With the Norsepower technology in general the fuel savings potential can be up to 30% and expected long-term ROI is around 20%.At the moment there are no practical auxiliary wind propulsion solutions available on the market. Norsepower has already succeeded in building a working prototype of its auxiliary wind propulsion technology and demonstrated its performance in operational environment in small scale.The global long-term market potential for the technology is 20 000 vessels and 30 B€. The high level of cargo vessel emissions is a big global and EU-level challenge and the maritime industry is lacking
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Examining the use of Metamaterials for acoustic applications'.

assistant: **Objectives**

MetaSonics is an acoustic metamaterial technology that shapes sound (and ultrasound) fields. Our solution is to build an adjustable device that transforms an input acoustic wave into a time-variable, user-defined acoustic field. MetaSonics comprises of a surface made of electronically adjustable acoustic metamaterial bricks. Each brick in the surface can individually vary the phase of an incident acoustic field in order to shape the complex output field.Our vision is to manipulate sound waves using advances in acoustic meta-materials to create novel interactive applications. We see an opportunity to be the world leaders in the design, manufacturing and distribution of MetaSonics a form of Spatial Sound Modulators (SSM) to shape the complex sound fields. MetaSonics has the opportunity to be ubiquitous as LCDs. Our devices will introduce an extremely cost-effective, reconfigurable, very compact and uniquely scalable technology solution. At this stage our potential markets include all applications that require shaped sound fields. This links us to a large and diverse range of potential markets, all of which offer business opportunities. Our focus within this PoC will be to create prototypes, develop commercial traction and develop an exploitation strategy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Neutrophil mediated lung injury: genetic susceptibility and new interventional therapeutic strategies'.

assistant: **Concept**

- To assess genetic predisposition to neutrophil-mediated lung injury via screening for a regulatory sequence mutation of the alphaPI gene. - To assess the potential of antioxidants to prevent inflammatory inactivation of antiproteases. - To assess the ability of antiproteases, alone and in combination with antioxidants, to modulate inflammatory cytokine production by lung cells.A dominant feature of the inflammatory response in the majority of chronic and acute respiratory diseases is an influx on neutrophils to the lung where, via the release of destructive proteases and oxidants, they mediate the tissue injury which results in morbidity and death. Development of early-onset emphysema in individuals with congenital deficiency of the protease inhibitor, alpha1PI, first highlighted the importance of antiprotease defenses in protecting the lung against neutrophil mediated injury. Recent studies indicate that a newly identified mutation in the regulatory sequence of the alpha1PI gene may also confer susceptibility to the development of chronic pulmonary disease. Via genetic screening the project will determine the incidence of this novel mutation in European patient populations and assess whether this mutation might also contribute to individual variation in severity of chronic lung disease and in susceptibility to acute luna injury. Given the central role of neutrophil proteases in mediating lung injury, measures to increase the antiprotease defenses of the lung are of considerable therapeutic interest. A significant problem in the development of effective antiprotease therapies is their susceptibility to oxidant and protease inactivation in the inflamed lung. However, if they can survive inactivation recent studies suggest that, in addition to protecting against direct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Quality and costs of primary care in Europe'.

assistant: **Objectives**

The overall objective of this project is to use research methods to describe different primary care models in Europe, assess their quality in different dimensions – particularly access, equity and satisfaction - and determine their cost. We will analyse variations of both quality and cost as they apply to specific organisational models in Europe, and will study the possible trade-offs between quality and costs in each model. Key research challenges will be the following: (i) to apply an innovative approach to identify and describe European primary care models, (ii) to develop and pilot a methodology to study relevant healthcare costs at macro and micro-level, and (iii) to combine surveys addressing perceptions of public and health professionals along with a review of clinical data to assess quality. The results of the project will develop, test and apply a valid framework for trans-national comparisons of quality atributes and costs with which to facilitate decision making concerning primary care models, the behaviour and delivery of primary care services. This framework will be an asset for those countries aiming at putting primary care at the centre of their healthcare model in terms of its quality, and in perspective with the total costs of healthcare provision and with the state of primary care in Europe. In summary, the core aim of the consortium is to inform policy decisions on primary care, giving explicit evidence of what measures can crucially be used to improve the overall quality of health systems, emphasizing their equity, evidence base, social cohesion, and sustainability as the values underlying the design of primary care models and its provision to European citizens.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Metadata Enhanced Digital Camera with Universal Format for Multiple Broadcast, D-Film and E-Cinema Applications' (METACAMERA) targeting Sixth Framework.

assistant: **Abstract**

The METACAMERA project aims to investigate and implement the real-time handling of wide bandwidth picture content from the high resolution, high frame rate cameras that will be demanded for future D- and E-cinema applications. Such a camera was developed in the MetaVision project and will be used as a research tool to enable the project to study, identify and deliver technologies for transferring the high bandwidth content in real-time through existing communication infrastructures, by the implementation of loss-less and near loss-less compression and a novel motion handling approach. This will include real-time conversion to other resolution and frame rate formats. There is user need for live in-camera processing and this will be addressed similarly through a technology study.The creation of special effects such as slow motion and variable frame rate using local storage in real-time for live broadcast (e.g. sports) and E-cinema will be developed and demonstrated. In parallel with this, new formats will be actively submitted to the international standardisation process, including extensions to the proposed worldwide standard MXF format. A roadmap of technology will describe the steps for implementation of the technology from the separate hardware elements we envisage in this project through to future autonomous camera implementations. Users from the broadcast, film and post-production industries will contribute their expertise and current and future requirements to ensure that the proposed system meets their operating needs. User trials will be undertaken to investigate the quality and performance of the proposed system under real operation conditions using a representative range of moving image content.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Gods’ Shadows. Anthropologies of (Divine) Kingship in Central Asia: Persia, Greece, India, and the Steppes: ca. 330-150 BCE' (Divine) targeting Horizon Europe.

assistant: **Abstract**

The Gosh project will develop a comparative anthropological framework to investigate Central Asian kingship, roughly modern Afghanistan, Northern Uzbekistan, Western Tajikistan, Eastern Turkmenistan, during the Hellenistic period, aiming at replacing outdated binaries that rely on shopworn dichotomies (Greek/Oriental, East/West), or leave the vast extent of Central Asia embedded in ‘Silk Road’ narratives of transit and exchange merely linking other ‘core’ regions of ancient Afro-Eurasia. World-historical, comparative research on kingship does not engage with Central Asian material, particularly coins, a key source on Baktrian ideology of power. Specialists in the region overlook the potential of the social sciences (especially anthropology) for their agendas. By focusing on the Hellenistic Baktrian Empire (ca. 330-150 BCE), I seek to bridge this divide, offering a new methodological framework for approaching Central Asian kingship comparatively across disciplinary boundaries and scholarly traditions. I aim to do so by comparing the coins’ visual vocabulary and titles with Near Eastern (particularly Achaemenid), Indic, and steppic sources on the ideology, rhetoric, visual cultures, and performances of kingship to redress the focus on Alexander’s model, showing how Baktrian monarchy emerged out of the interplay of multiple distinct but interconnected traditions. The project draws on anthropological theories of sacred kingship to examine the role played by religious and cultic traditions in shaping royal self-representation and driving cultural and political change, contributing to the scholarship of global history, political theory, and anthropology. GOSH will present a revisionist theory of the spiritual politics of Baktrian kingship based on a new empirical understandin