RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'High-Dimensional Sparse Optimal Control' to be submitted under Seventh Framework.

assistant: **Abstract**

We are addressing the analysis and numerical methods for the tractable simulation and the optimal control of dynamical systems which are modeling the behavior of a large number N of complex interacting agents described by a large amount of parameters (high-dimension). We are facing fundamental challenges:- Random projections and recovery for high-dimensional dynamical systems: we shall explore how concepts of data compression via Johnson-Lindenstrauss random embeddings onto lower-dimensional spaces can be applied for tractable simulation of complex dynamical interactions. As a fundamental subtask for the recovery of high-dimensional trajectories from low-dimensional simulated ones, we will address the efficient recovery of point clouds defined on embedded manifolds from random projections.-Mean field equations: for the limit of the number N of agents to infinity, we shall further explore how the concepts of compression can be generalized to work for associated mean field equations.- Approximating functions in high-dimension: differently from purely physical problems, in the real life the ”social forces” which are ruling the dynamics are actually not known. Hence we will address the problem of automatic learning from collected data the fundamental functions governing the dynamics.- Homogenization of multibody systems: while the emphasis of our modelling is on “social” dynamics, we will also investigate methods to recast multibody systems into our high-dimensional framework in order to achieve nonstandard homogenization by random projections.- Sparse optimal control in high-dimension and mean field optimal control: while self-organization of such dynamical systems has been so far a mainstream, we will focus on their sparse optimal control in high-dimension. We will invest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Patient Information Combined for the Assessment of Specific Surgical Outcomes in Breast cancer' in the context of a Seventh Framework call.

assistant: **Objectives**

Breast cancer is the most common cancer to affect women in Europe and has a lifetime risk of 1 in 9. It is an increasingly treatable disease, however, and 10-year survival now exceeds 80%. Thus many women will live for many years with the potentially disfiguring aesthetic consequences of their treatment. When a woman faces a breast cancer diagnosis, and surgery is proposed, two options are available: breast-conserving surgery or mastectomy. The decision as to which type of surgery to offer patients is totally subjective and based almost exclusively on the judgment and experience of the clinician. In breast-conserving surgery, approximately 30% of women receive a suboptimal or poor aesthetic outcome, however there is currently no standardised method of identifying these women.The PICTURE project aims to address this issue by providing objective tools to predict the aesthetic outcome of breast conserving surgery. Using a combination of 3D photography, together with routinely acquired radiological images (i.e. mammography, ultrasound and MRI, when available), we will develop techniques to biomechanically model the anatomy of the breast and the effect of surgical removal of cancerous tissue. These predictive tools will enable alternative surgical strategies to be explored and the consequences of the available options, with respect to the appearance of the breast, to be visualised. This will aid communication of the type of breast surgery recommended by the surgeon, to the patient, and will empower patients to take an active role in a shared decision making process. These tools will also enable the patient's aesthetic appearance after treatment to be objectively evaluated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of industrial solutions for the recycling and valorization of the olive oil fabrication residues for biopolymers and fine chemicals', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The olive oil industry is a major activity in Southern Europe and the Mediterranean basin, which produces 95% of the world olive oil, 2.4 Mt, and 30 Mt of solid/liquid residues, alpeorujo". The project will develop new processes to valorise the alpeorujo in the biopolymer and fine chemical industries. The lignin and cellulose contained in the solid residue "Trujillo" will be transformed by liquefaction into new polymer components for polyurethane/phenoplaste polymers and will replace the polio/phenol components issued from the neurochemistry. The fats contained in the liquid residue "alp chin" will be extracted by a vegetal adsorbent made with hydrophone Trujillo and other vegetal fibbers. This process should allow the recovery of fine chemical products from the fats for further valorisation in the pharmacology."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Runic Kitsch: Medieval Modernity, Modern Medievalism, and the History of Philology' (RUNEKITSCH).

assistant: **Innovation**

This research project will examine a history of views of pre-Christian Scandinavia that begins in the High Middle Ages and continuesin the present day, focusing on a persistent association between runic inscription, eddic poetry, and magic. Rather than continuitiesor survivals of pre-Christian practices into the Christian period, this research will reveal them as fundamentally High to Late Medievalpractices (such as magical runic inscriptions using eddic meters, and eddic poetry referring to runes and magic) showing a form ofalienated attraction toward the pagan past. The survival of this attitude will be traced through the Early Modern period, in whichlearned writers not only take these Medieval Christian textual objects at face value, but also reproduce their stance of alienatedattraction, continuing to view the pre-Christian past as a source of esoteric knowledge. Finally, we see this view continuallyreproduced through the nineteenth and twentieth centuries even as modern philology continues to develop. In this period, we alsosee both “serious” scholarship on this subject and para-academic occultist interest in it become increasingly entangled with thepolitics of the far right. Ultimately this research will reveal the continuing stance of alienated attraction as a form of runic “kitsch.” Theproject will be carried out in four phases to cover the necessary methodological concerns and sources from three periods (Medieval,Early Modern, Modern). The results will be disseminated as a monograph manuscript, as well as in media articles and through papersgiven at international conferences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Resolving the Nuts and Bolts of Gene Body Methylation' (GeneBodyMethylation) targeting Horizon 2020.

assistant: **Abstract**

DNA methylation, the covalent binding of a methyl group (CH3) to cytosine base, regulates the genome activity and plays a fundamental developmental role in eukaryotes. Its epigenetic characteristics of regulating transcription without changing the genetic code together with the ability to be transmitted through DNA replication allow organisms to memorize cellular events for many generations. DNA methylation is mostly known for its role in transcriptional silencing; however, its functional output is more complex and is influenced in part by its DNA context. Recent genomic studies, have found DNA methylation to be targeted inside sequences of actively transcribed genes, thus termed gene body methylation. Despite being an evolutionary conserved and a robust methylation pathway targeted to thousands of genes in animal and plant genomes, the function of gene body methylation is still poorly understood at both the molecular and functional level. Similar to the chicken and egg conundrum, because we do not know what gene body methylation does, therefore scientists could not apply its function to discover its regulators either. Gene body methylation is targeted to a very specific subset and subregions of genes, thus we strongly believe that specific factors exist and are missing simply because that no one has ever searched for them before. Hence, to make major breakthroughs in the field, our approach is to artificially generate gene-body-specific hypomethylated plants that together with customized genetic and biochemical systems will allow us to discover regulators and interpreters of gene body methylation. Using these unique genetic tools and novel molecular factors, we will be able to ultimately explore the particular biological roles of gene body methylation. These findings w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'The reward system in healthy ageing and its modulation by gonadal steroid hormones: multimodal neuroimaging studies (fMRI/PET)'.

assistant: **Concept**

Reward processing plays a fundamental role in motivation, learning and cognition. Using fMRI in humans, we recently identified the neural structures involved when anticipating uncertain rewards. Cognitive impairments and dysfunction of the dopaminergic system are observed in healthy aging and in several neurological and psychiatric disorders. Moreover, damage from stroke and neurodegeneration in dementia may be retarded by estrogen and estrogens may prevent the deleterious effects of aging on cognition when administered soon after the cessation of ovarian function. However little is known about the effects of ageing and hormone replacement therapy (HRT) on the reward system and dopamine synthesis. The goals of this research program are to investigate the role of ageing in men and women and the effect of age-related hormonal decline in post-menopausal women with and without hormone replacement therapy on activation of the reward system and on dopaminergic. Using both fMRI and fDOPA PET, we shall investigate: 1) the activation of the reward system with fMRI in our monetary reward task; 2) dopamine synthesis in the midbrain and the striatum using F-DOPA PET; 3) the relationships between activation of the reward system and the levels of midbrain/striatum dopamine synthesis by combining fMRI and F-DOPA PET results in the same individuals; 4) the effect of HRT on the reward system and the dopaminergic function in post-menopausal women. Our findings should clarify the relationships between activation of the reward system, dopamine synthesis and the effect of ageing and HRT.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Twinning to excel materials engineering for medical devices' under Horizon 2020.

assistant: **Concept**

The aim of the ExcellMater project is to advance the research and innovation capacity of the Faculty of Technology and Metallurgy, University of Belgrade (FTM) in the area of biomaterials engineering by efficient knowledge and skills twinning activities and by creation of a sustainable collaborative network with leading international institutions: Aalto University, Finland, Università del Piemonte Orientale, Italy, and AO Research Institute Davos, Switzerland. The project addresses a translational gap in development and utilization of novel biomaterials in medical devices, arising from the lack of relevant procedures and expertise at FTM regarding biological and clinical evaluation of biomaterials, regulatory issues and IPR exploitation strategies. The twinning activities will include short-term staff exchange missions, site expert visits, workshops, summers schools, specialized seminars with dedicated actions towards early stage researchers as well as trainings of FTM staff in project proposal writing and project management. The actions also involve the local partners in the areas of medical and life sciences, innovation and technology transfer organizations and industry to build a functional ecosystem around FTM for successful translation of scientific results from bench-to-bedside.This will assist in overarching the gap by increasing the S&T capacity of FTM and its staff research profile. Efficient dissemination and communication actions will be complemented with an international conference on biomaterials and medical devices as the final project event to increase the FTM national and international visibility, attract major biomedical stakeholders and raise the biomedical awareness of the society at large. The project will ultimately impact on establishment of succes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrated Quantum Clock' (2014-2020).

assistant: **Concept**

Optical clocks are amazingly stable frequency standards, which would be off by only one second over the age of the universe. Bringing those clocks from the laboratory into a robust and compact form will have a large impact on telecommunication (e.g. network synchronization, traffic bandwidth, GPS free navigation), geology (e.g. underground exploration, monitoring of water tables or ice sheets), astronomy (e.g. low-frequency gravitational wave detection, radio telescope synchronization), and other fields. Likewise, techniques developed for robust clocks will improve laboratory clocks, potentially leading to physics beyond the standard model. To make this a reality, we have founded the iqClock consortium, assembling leading experts from academia, strong industry partners, and relevant end users. We will seize on recent developments in clock concepts and technology to start-up a clock development pipeline along the TRL scale. Our consortium represents a nucleus for a European optical clock ecosystem, which will continuously deliver competitive products and foster the development of clock applications. Our first product prototype will be a field-ready strontium optical clock, which we will benchmark in real use cases, such as network synchronization (TRL 6). This clock will be based on a modular concept, already with the next-generation clocks in mind, which our academic partners will realize (TRL 3-4). By their operation principle, these optical clocks are more robust than the current ones and have come into reach by recent breakthroughs, some of which achieved by our partners. We will leverage the foundational work by the consortia QuantERA Q-Clocks and JRP f17 USOQS, which have joined partners with us, and translate their work into a higher TRL. To increase our impact an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Actionable systems integration for energy-enabled sustainable development in sub-Saharan Africa' (IntegrateEnergy).

assistant: **Concept**

Current approaches to increasing energy access in sub-Saharan Africa (SSA) are not working. In 2022, 570 million people had no electricity access in SSA, 130 million more than in 1990 and 10 million more than in 2021. Energy poverty hinders much-needed progress on the UN’s Sustainable Development Goals (SDGs). Many international donors, including the EU, are funding large energy access initiatives in SSA, but recent impact studies show that they often fail prematurely and create little wider SDG impact.IntegrateEnergy proposes a paradigm shift towards integrated solutions that prioritise useful energy services such as irrigation, neonatal incubation or cold chains over mere electricity connections. Finding feasible options for systems integration captures key synergies for energy-enabled sustainable development (EESD). It requires to overcome four design failures of existing energy access initiatives: Conceptually, the initiatives view energy access as an end in itself. IntegrateEnergy  displaces siloes with actionable systems integration. Strategically, the initiatives are guided by least-cost electrification rather than the needs of local people. IntegrateEnergy captures local visions of development and translates them into efficient, feasible strategic plans for EESD. Institutionally, the initiatives are highly fragmented. IntegrateEnergy examines feasible options for policy and institutional integration to govern EESD effectively. Operationally, current delivery models are limited to providing energy connections. IntegrateEnergy finds feasible modes of operation which reconceptualise value creation towards EESD.∫Energy addresses the design failures, and their underlying theoretical gaps, through a ground-breaking, interdisciplinary mix of modelling, socio-technical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Systematic study of IgG4-autoimmune diseases to develop new treatment strategies'.

assistant: **Innovation**

IgG4-autoimmune diseases (IgG4-AID) are rare but collectively correspond to a significant group of devastating diseases affectingmany different organs, e.g. skin, brain, nerves and kidney in patients that often remain unresponsive to current treatments. IgG4-AIDhave commonalities indicating a shared underlying immunopathogenesis that make a joint approach to identify new therapeutictargets and test new treatment strategies feasible and necessary. We hypothesize that genetic risk factors and a dysregulatedimmune response may lead to an increased susceptibility to produce antibodies targeting self-proteins. These are of a specialsubclass called IgG4, which are usually harmless but can cause disease in these patients by interfering with normal functions in thebody. We are the first consortium that aims to study IgG4-AID comparatively, including pathogenic IgG4, and the cells, molecules andmechanisms involved in IgG4 autoantibody production, using an explorative multi-omics approaches in combination with state-ofthe-art cell and molecular biology methodology. We will establish a new humanized mouse model of IgG4-AID for the developmentand testing of a novel immune-apheresis based therapy aimed as immediate relief therapy for all IgG4-AID patients. Our innovativetraining program combines university-based and multidisciplinary research-based training with state-of the art web-based trainingand in-person trainings by the academic and non-academic sector. We aim to foster a new generation of experts in IgG4-AID that are1) are highly employable both in the academic and industry sectors and qualified for innovative multidisciplinary translationalresearch with a focus on biomedical product development and 2) equipped with the skillsets for digitalization, awareness for genderequal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Surrogate end-points for future intervention trials in individuals at risk for insulin-dependent diabetes mellitus' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Objectives: The objectives of this proposal is therefore to develop, refine, validate and standardise assays of existing and novel markers for humoral and cellular anti B-cell autoimmunity with the aim of using these markers as surrogate end-points for IDDM development to be used in future intervention trials in individuals at risk.Brief description: Recent advances in immunobiology has made it possible to identify individuals at high risk for development of IDDM, and studies in animal models have clearly shown that IDDM is a preventable disorder. B-cell mass can be preserved by immunointervention after the onset of overt IDDM, and promising pilot studies have indicated that B-cell mass may be protected in individuals at risk by the administration of the B-vitamin nicotinamide. This concept is currently being trialed with concerted action funding from the European Commission in the European Nicotinamide Intervention Trial (ENDIT). Other promising preventive interventive strategies need to be tested in the near future. The pool of individuals in risk is a precious resource and current studydesigns require large number of individuals if development of IDDM in risk individuals is the only outcome parameter. There is therefore an urgent need for development of surrogate end-points of IDDM development, which can provide an outcome measure in smaller samples of individuals and after shorter follow-up periods.The cellular markers will be studied at different levels of refinement and technical complexity ranging from proliferative and cytokine secretory responses of leukocytes and whole blood cultures in response to non-antigen and antigen specific stimulation, to T-cell reactivity at the clonal cultures in response to non-antigen and antigen specific stimulation, to T-cell rea