RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quasirandomness in Graphs and Hypergraphs' under Seventh Framework.

assistant: **Concept**

A structure is called quasirandom if it has a number of properties that one would expect from a random structure with similar parameters. For instance, a graph is quasirandom if its edges are spread evenly over the vertices. This concept has been remarkably useful in many areas, including Number theory, Graph theory and the design of algorithms.Quasirandomness is a field that is developing very rapidly, but there are many connections and properties that are still unexplored. In my proposal, I will concentrate on 4 important topics where I believe that quasirandomness is crucial to further progress: hypergraph matchings, decompositions of graphs, topological subgraphs as well as sparse graphs and hypergraphs.As an illustration of a matching problem, consider a group of people and construct a graph by drawing an edge if they like each other - a perfect matching splits the people into teams of 2 which can work together. How and when this can be achieved for teams of 2 is well understood, but not for teams of 3 or more people. This can be formulated as a hypergraph matching problem. I believe that quasirandom decompositions can be used to give quite general sufficient conditions which guarantee a perfect hypergraph matching.A better understanding of quasirandomness of sparse hypergraphs would have applications e.g. to checking whether a Boolean formula is satisfiable. This is one of the fundamental problems in Theoretical Computer Science.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Generation of AAV-based, arrayed genetic libraries for in vivo functional selection: an innovative approach to identify secreted factors and microRNAs against degenerative disorders'.

assistant: **Innovation**

A foremost health problem stems from the burden of degenerative diseases, including heart failure, neurodegeneration, retinal degeneration and diabetes, essentially linked to the aging of the human population and the incapacity of post-mitotic tissues to undergo efficient repair. This is an ambitious, highly innovative project aimed at developing an in vivo selection procedure, based on gene transfer of two genetic libraries cloned into Adeno-Associated Virus (AAV)-based vectors, for the identification of novel secreted factors or microRNAs providing benefit against various degenerative diseases. Two arrayed libraries will be generated, one coding for ~1,300 cDNAs from the mouse secretome, the other for all known microRNAs (~800 genes). Pools of vectors from each library will be obtained with serotypes suitable for in vivo transduction of different organs. The vectors will be injected in a series of mouse models of degenerative disorders involving damage to cardiomyocytes,, neurodegeneration, retinal degeneration and loss of beta-cells in the pancreas. The degenerative conditions will drive the selection for secreted factors or miRNA putatively preventing cell apoptosis, enhancing residual cell function or, in the best possible scenario, promoting tissue regeneration. This in vivo selection approach, which is supported by very encouraging preliminary results, has never been attempted before and is rendered possible by the property of AAV vectors to be produced at high titers, infect tissues at high multiplicity, persist in the transduced cells for prolonged period of times and efficiently express their transgenes in vivo. In addition to its final goal of identifying novel biotherapeutics, the project entails the successful achievement of several intermediate objectives
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Intelligent Airbag Model Systems Based on Environmental Friendly Gasgenerators'.

assistant: **Innovation**

Objectives and content The actually used airbag gas generators based on NaN3 produce harmless gases. However, the basic material is extremely toxic and induces risks with respect to production, storage, transport, processing and environmental impact. Worldwide research activities aim at its substitution. It is the objective of the research project to develop a model airbag gas generator which shows an economic solution as an alternative to NaN3 on systems of more intelligent and flexible reactions on accidents - a two-chamber airbag gas generator with a fast and slow gas output - no environmental and toxic impacts - reduced costs - long term stable The model airbag module will show a gas output exceeding actual gas generators by a factor of 1.5 and reduced costs of about 0.75. It will be: - based on a non-toxic gasgenerator producing only nitrogen and carbon dioxide with trace constituents far below the limits of regulations: - a concept of module to react flexible on accidents combining gas production unit in e.g. a two stage generator with an adapted igniter and electronics and sensorics which take into account the complexity of an accident The successful development will bring car occupant systems to a new level of technological stage. The complementary activities of the project partners allow the development of a complete new system being able to be brought to the market 3 years after project end.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Patient Centric Approach for an Integrated, Adaptive, Context Aware Remote Diagnosis and Management of Cardiovascular Diseases'.

assistant: **Innovation**

BRAVEHEALTH proposes a patient-centric vision to CVD management and treatment, providing people already diagnosed as subjects at risk with a sound solution for continuous and remote monitoring and real time prevention of malignant events. The solution proposed will be made up of the following sub-systems: 1)WEARABLE UNIT: it is an innovative concept of miniaturised multi-parameter sensor,  able to continuously monitoring the most critical parameters needed to perform a thorough diagnosis by means of specific diagnostic and prognostic algorithms running on it. It will be possible both to perform scheduled analysis of critical parameters and to remotely trigger the screening of specific vital signs. 2)REMOTE MANAGEMENT UNIT: it represents the main interface between physicians and the system, providing both automated support, in the form of text messages with information or suggestions to the patient directly generated by the system, and doctor managed supervision, allowing direct communication with the patients with voice/text/chat messages. The most important added value of the this unit is the possibility to be interfaced with existing National Health Records and Physiological Data Banks in order to generating and verifying risk prediction models using advanced data mining approaches. 3)LIFE! GATEWAY: Data acquired by the wearable unit will be relayed to a gateway which represents the means by which the information flow from the user to the Central Supervision Unit. This unit will provide the user with the following functionalities: a)Real time communications: in case of anomalies, or simply to suggest specific drugs to be taken, or to advice some particular activity to be performed; 2)Location aware information, exploiting the positioning capabilities of GPS. 3)Mobile
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MOnitoring VEgetation status and functioning at high spatio-temporal resolution from Sentinel-2' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Leaf Area Index (LAI), Fraction of green Vegetation Cover (FCOVER) and Fraction of Absorbed Photosynthetically Active Radiation (FAPAR) are key biophysical variables representing the status and functioning of vegetation. High spatiotemporal resolution LAI/FAPAR/FCOVER products are urgently needed in many terrestrial applications including crop and forest management. However, the trade-off in traditional remote sensing sensors between temporal and spatial resolutions hinders the generation of such products. The launch of Sentinel-2 satellites, with spatial resolution of 10-20 m and 5-day temporal sampling (in tandem), opens a new paradigm in satellite vegetation monitoring. The proposed project “MOVES” will develop an operational algorithm for retrieving LAI/FAPAR/FCOVER from Sentinel-2 data. An easily-invertible radiative transfer model (RTM) will be firstly developed, which will apply a universal model framework for all vegetation types (continuous vs discrete) and terrains (horizontal vs sloping). In this project, the hybrid training and domain adaption paradigms will be introduced into the retrieval of LAI/FAPAR/FCOVER, to enhance the transferability of the retrieval algorithm and achieve spatiotemporally consistent retrieval. The Copernicus ground-based observations (GBOC) and FLUXNET sites will be used to validate the proposed algorithm and assess its potential in the monitoring of vegetation status and functioning. The project is conceived to combine the prominent expertise of the hosting institute in biophysical variable retrieval and remote sensing ecological application, with my well-demonstrated RTM development skills. Overall, MOVES will facilitate the delivery of Sentinel-2 LAI/FAPAR/FCOVER products of physical consistence and high accuracy, and underpin new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The prerequisites of the elderly for living at home: criteria for dwellings, surroundings, and facilities', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The purpose of the project is to improve the conditions of living at home of the elderly. Our specific purpose is to focus on the prerequisites of living at home in presently existing dwelling stock, rather than ideal newly built environments. The project will:1. Clarity the present situation both in terms of supply on the market and by organisations, and demand, as expressed in the needs and wishes of the elderly.2. Develop sets of criteria that cover the preconditions of the elderly for living at home as regards the dwelling, its surroundings and facilities providing services and infrastructure.3. Test and improve sets of criteria, after work in empirical cases.4. Suggest dissemination plans for authorities, builders, service organisations etc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Technology to turn waste from rapeseed oil production into valuable food protein.' to be submitted under Horizon 2020.

assistant: **Abstract**

The continuing growth of world population is pushing demand for food. Climate changes and limited resources for farming lead to increased interest in new sources of nutrients alternative to meat. Additionally, human diet undergoes a significant shift towards proteins. Therefore, the growth of plant protein market is predicted to be drastically driven up in the coming years. Oilseeds, known for their high content of nutritious proteins, are expected to take center stage as main source of plant proteins aimed for human consumption. Nowadays, the main product of rapeseed processing is oil. A by-product – rapeseed cake – is used as animal feed. There is no commercial technology capable of extracting fully functional protein from rapeseed cake. At NapiFeryn BioTech (NFB) we came up with a new technology which allows more efficient use of this by-product. Our technology is protected with three patent applications. It enables full recovery of high-quality rapeseed cake proteins, ready to be used in food industry. Our business model is based on licensing of the technology to rapeseed processors. Licensing fee will be calculated individually for each oilseed processor or integrated formulator, based on the annual scale of the processed rapeseed. We have validated the pricing strategy with rapeseed processors. The first license agreement has been signed already in 2016. In the Ph2 project we aim primarily at delivering full-scale demonstrator (TRL9) of the rapeseed protein isolation technology at the commercial level (market launch), collect and prove all the data needed to quantify the cost-effectiveness of our technology. These activities will provide the input required for the main deliverables of the project: The Basic Engineering Level design of Biorefinery. With our technol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '3D silicon detector for imaging of diagnostic  and therapeutic nuclear medicine radiotracers with outstanding efficiency and high spatial resolution.' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

This project aims to design, construct, and evaluate a novel instrument for molecular imaging of radioactive nuclides in the human body. The hypothesis is that, by using next-generation silicon sensors to measure each photon interaction and applying kinematic constraints, the incident photon direction can be calculated. Thus, we can remove state-of-the-art mechanical collimators. The main objective of this project is to explore the physical limits of efficiency and spatial resolution and evaluate the concept for this new technology in medical imaging applications.The new instrument should improve detector efficiency by about a factor of one million, reducing examination time from an hour to less than a second.  The concept aims to overcome Compton cameras' shortcomings such as complicated geometries with low efficiency, that, despite several attempts, prevented this technique from going beyond an early prototype stage. The new sensor concept consists of a massive block of silicon built up from a multitude of sensors, with high resolution in space, energy and time and including signal shaping and data processing. The system will have orders of magnitude more read-out pixels than ever before in medical imaging. The system design and image reconstruction process are conceptually challenging, addressing several scientific problems at the component level such as pixel charge collection and capacitance, but also including image reconstruction from fragments of event circles, combinatorial problems involved with tracing each event to discern the correct order of interactions and to reject background events. Over a 10–20-year period, the technology could replace the current installed base, leading to significant impacts on adjacent research fields, such as drug development and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Phage infection of bacterial biofilm', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

In 2017, the World Health Organization declared Staphylococcus aureus to be an antibiotic-resistant pathogen for which new therapeutics are urgently needed. Upon infection, S. aureus forms biofilms that can only be treated by the long-term application of several antibiotics in high doses or the surgical removal of the infected tissues. An alternative approach, phage therapy, has not been approved for clinical use, because the effects of phage infection on a biofilm are not sufficiently characterized. We propose to study the dynamics of the propagation of Herelleviridae phage phi812 in a S. aureus biofilm and molecular details of phi812 replication in a cell. We integrated a microfluidic system into a light-sheet microscope to enable continuous multi-day observation of the phage infection of a biofilm. We will determine how sub-populations of metabolically dormant or phage-resistant cells in a biofilm provide herd immunity against phi812 infection. Our system enables the fixation of biofilm segments for subsequent correlative imaging by serial block-face scanning electron microscopy to identify the interactions of phages with bacterial cells. We will use focused ion beam milling together with cryo-electron microscopy and tomography to determine high-resolution structures of previously uncharacterized phi812 replication and assembly intermediates in S. aureus cells. We will study the function of bacterial membranes and macromolecular complexes in the initiation and completion of phage genome delivery, the assembly of phage portal complexes and heads, and the mechanisms of genome packaging and head-tail attachment. This proposal’s biological significance lies in its focus on the as-yet uncharacterized interactions of phages and bacteria under biologically and clinically re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Membrane lipid composition as new antitumor therapeutic target: sphingomyelin synthase (SGMS) at the basis of Minerval® mechanism of action and design of new Minerval®-related drugs' (SGMS).

assistant: **Concept**

MembraneLipidTherapy proposal is a translational research project introducing an innovative therapeutic approach for fighting cancer disease that takes advantage of inter-sectoral industry-academia strengths and international cooperation.Membrane Lipid Therapy relies on the specific lipid composition from the cell membrane in tumour cells as a strong element controlling tumour growth surpassing oncogene activation or tumour suppressor inactivation. Particularly the ratio of membrane lipids phosphatidilethanol-amine:sphingomyelin (PE:SM) is ten times higher in tumour cells when compared to wild type cells.This finding allowed the host group to rationally design the new antitumor drug Minerval®, first known activator of sphingomyelin synthase (SGMS-1 and -2), the protein responsible for maintaining the balance between PE and SM in the membrane by using the former as substrate to synthesize the latter. Minerval®, developed by Lipopharma Therapeutics (spin-off company from University of the Balearic Islands), is currently in multicenter phase II clinical trial for treatment of gliomas and other solid tumours.All of the above supports Minerval® relevance as new antitumor therapy; however, further characterization of the molecular mechanism underlying Minerval® action is needed for approval and distribution of Minerval in the next future. The aim of this project is to gain more insight in this issue.Laboratory animal models combined with histology techniques, microscopy and imaging and molecular biology techniques together with analytical chemistry, molecule structure techniques and computer-aided drug design will be used to determine:1. The molecular mechanism underlying the altered PE:SM ratio in tumour cells.2. The domains in SGMS interacting with Minerval.3. The molecular
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A QUALITATIVE STUDY OF THE CAREER DECISIONS OF ASTROPHYSICISTS: RELOCATION, LIFE-WORK BALANCE, AND REPUTATIONS (ASTROMOVES)'.

assistant: **Concept**

The number of members of underrepresented groups (including women & Eastern Europeans for the EU) participating in science, technology, engineering, and mathematics continues to be of concern at the local, national, and international level including it being a priority of MSCA. The issue of underrepresented groups participating fully in astrophysics has been a long-standing concern of astrophysicists worldwide. Astrophysicists recognize the importance of mobility in building a scientific career, but social science research revealed that women astrophysicists have to move more often & stay abroad longer to achieve the same career rank as men (analysis has not been done for astrophysicists embodying other forms of underrepresentation). ASTROMOVES examines the careers of astrophysicists (men, women & the gender diverse), their career decision-making and the role of mobility. 50 astrophysicists (European or worked in Europe) more than 8 years past their doctorate (>two career relocations), will be interviewed using semi-structured interviews focused on each of their career moves & their underlying decision-making process. Of interest is if their decision-making includes perceptions of scientific reputation, discrimination/bullying, family friendliness & career enhancement and how each astrophysicist ranks these. Training includes learning the latest qualitative analysis software for analysing the interviews and the latest visualization techniques for showing career moves consecutively. The research results will inform policies to support & enhance the careers of underrepresented astrophysicists with broader implications for STEM in Europe. Project deliverables include peer-reviewed articles, scholarly presentations, public lectures & a documentary film. The project will be