RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Self-healing screen-printed perovskite photovoltaics beyond Shockley–Queisser Limit' (SHERPA) under Horizon Europe.

assistant: **Objectives**

Due to environmental benefits, scalability, competitive cost and limited maintenance, photovoltaic (PV) systems are the fastest-growing renewable energy technology enabling large-scale carbon-free electricity production. Within the family of PV systems, Metal Halide perovskite (MHPs) solar cells are the most performant at converting sunlight to electricity, due to their excellent optoelectronic properties and cheap fabrication process. MHP based on hybrid organic–inorganic lead halides are the most effective perovskite solar cells. Yet, there are two major challenges to widespread adoption of lead based LHP PV: (i) Instability, especially against moisture and ii) High level of lead (Pb) and lead leakage which are toxic to humans and wildlife; according to EU’s “Restriction of Hazardous Substances” (RoHS) directive. This proposal will develop for the first-time perovskite photovoltaics with self-healing capabilities while decreasing lead leakage to near zero, by transferring the microconcentrator PV concept to MHP. Such a configuration enables to save 90 to 99% raw materials compared to a planar device. More importantly, it increases the theorical efficiency and reduces the Pb content and leakage. So, the main goal of this proposal is to boost the stability of lead halide perovskite PV systems by introducing microconentrator PV concept and concentrated light to MHP in addition to taking advantages of microconcentrator PV i.e., physical separation and embedding of each microcell, to enable the PV system to theoretically exceed the Shockley–Queisser limit and reduce toxic lead levels to below RoHS requirements. SHERPA’s achievements will make advancements on cutting edge MHP solar cells that are pivotal to reach EU’s environmental targets for a reliable and green energy tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Technology for the production of health related substances by marine sponges' (SPONGE) targeting Fifth Framework.

assistant: **Abstract**

Interesting new compounds have been isolated from marine sponges: e.g. cytotoxic compounds that may be used as anti-cancer drugs, antibiotics, anti-viral agents and compounds with anti-inflammatory and cardiovascular properties. Biotechnological production under well defined conditions of sponge biomass is a necessary step towards commercialization of these potentially interesting products. So far, no primary-cell suspension cultures showed growth. Sponge cells need cell-cell contact to proliferate. In order to obtain axenic sponge tissue cultures, sponges can be dissociated, cleaned from other organisms than the sponge cells and reaggregated. Primary cell cultures can be reaggregated to strong spherical aggregates, primmorphs. The goal is to develop a process for in vitro cultivation of marine sponges for the production of biological active compounds. Sponges will be grown as primmorphs in bioreactors. Optimisation of the growth of and isolation of bioactive components from these primmorphs is the main objective of the project. A process design (including the market analysis) will be made.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Retinal Vascular Modeling, Measurement and Diagnosis""'.

assistant: **Concept**

The REtinal VAscular Modeling, Measurement And Diagnosis (REVAMMAD) project will train a new generation of scientists able to effectively translate the latest vascular modeling theory and computerized image analysis techniques into effective interventions for some of the most important chronic medic conditions afflicting the EU, including hypertension and diabetes. It will particularly ensure that there is rich clinical and industrial involvement to ensure that the training is focused with end-users and exploitation in mind.The vasculature undergoes changes in response to early stages of these diseases, reflecting fundamental physiological processes within the vessels.The retina provides a unique “window onto the vasculature,” allowing it to be viewed and measurements made in vivo, and advances in imaging technologies make it increasingly possible to measure subtle changes using computer vision algorithms, including through routine medical checks such as eye tests.The field is currently fragmented, with many excellent pockets of collaboration focused on defined specialisms, particularly between clinicians and modelers, or clinicians and measurement specialists, but lacking overall structure. Despite the importance and incidence of the diseases and the evidence for the possibility of better diagnosis through imaging, there has been relatively little translation of theory into clinical practice.Integrative action is required to train researchers who understand the medical, clinical, technological and commercial aspects of the problem domain and to establish common working methodologies and tools across the field. REVAMMAD will train early careers researchers who combine these skills in order to motivate the introduction of high impact interventions in the future.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Paramagnetic, fluorinated and water-soluble metal complexes for 19F MRI' (PARA-FLUOR).

assistant: **Concept**

19F MRI relies mainly on the use of fluorine-dense perfluorocarbon nanoemulsions. However, poor water solubility, limited stability, droplet heterogeneity, rigorous liver accumulation of the particles, as well as the relatively long fluorine relaxation times often limit their applicability. Fe(III) and Mn(II) have the most advantageous paramagnetic properties to shorten T1 relaxation time of 19F without strong line-broadening T2 effect, deleterious for 19F MRI detection. The combination of these paramagnetic metal ions with small molecular weight ligands containing maximized number of magnetically equivalent fluorine atoms is proposed here to circumvent the problems associated with perfluorocarbon nanoemulsions. We will create complexes that provide high thermodynamic stability and kinetic inertness important for safe biological application, good water solubility, as well as short 19F T1 relaxation time, allowing for fast MRI scans and high signal to noise ratio. A series of open-chain and macrocyclic ligands will be synthetized and their Mn(II) and Fe(III) complexes characterized with respect to their application as 19F MRI agents (water solubility, thermodynamic and kinetic stability, 19F relaxation properties). Structural variations of the ligands will allow for optimizing the 19F-metal distance for optimized relaxation effect. For a proof of concept cell labelling study, we will choose dendritic cells (DC) and T lymphocytes (TL), two cell types frequently used for adoptive cell transfer strategies in oncology. Cytotoxicity and cell labelling capacity of the probes will be assessed and in vitro MRI phantom images will be acquired on cells labelled with the paramagnetic complexes.


**Keywords:** 19F MRI, Mn(II), Fe(III), cell labelling and tracking
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Biologically inspired chiral oxidation catalysts for commercial applications of fine chemistry'.

assistant: **Objectives**

The ERC-funded project BIDECASEOX ERC-239910 has produced a series of chiral catalysts with broad applicability in various commercial fields associated with synthetic organic chemistry. These catalysts are based in earth abundant metals and activate hydrogen peroxide to perform asymmetric introduction of oxygen atoms into readily available and cheap non chiral organic molecules, producing highly valuable chiral products, leaving water as the only byproduct. By virtue of these reactions, valuable chiral products that nowadays are only accessible by expensive enzymatic methods, or in some cases by toxic, expensive and large waste-producing traditional stoichiometric oxidants, become available in a sustainable manner. Pharmaceutical and agricultural industry, polymer chemistry and fine chemistry are envisioned as potential targets for the interest of the catalysts. With the aim of accelerating their access to the market, the present Proof of Concept (PoC) project, named CHIROXCAT, will target to study the feasibility of bringing these catalysts into a pre-commercial stage. This will be achieved by scaling-up current mg-scale synthetic methods, in order to establish economically optimized multigram scale procedures, and by validating their use in the production of representative chiral molecules of potential interest to the fine chemical industry. This PoC activity will also include an analysis of intellectual property (IP) protection needs within the field of application, as well as setting up the basis for any patent filling procedure required to provide an adequate protection of the catalysts and their uses. Moreover, a market study will be conducted to identify specific potential uses of these compounds, and a review of potential commercialisation partners will be carri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Monica: multinational monitoring of trends and determinants in cardiovascular disease cohort component'.

assistant: **Innovation**

Objectives: To establish a large European cohort study of CHD and stroke in men and in women in all centres with follow-up data in the MONICA Project: the estimated number of CHD events is 8,385 and stroke events is 2,983 by the end of 1997. To assess the predictive ability of the genetic polymorphisms of candidate genes for the subsequent development of CHD or stroke. To provide a scientific dissemination facility of the MONICA database in the form of CD files of data and also as a Monograph.The MONICA Project was established in the early 1980s in many Centres around the world to MONItor trends in Cardiovascular diseases (coronary heart disease (CHD) event registration is obligatory, stroke registration optional), and tolerate these to risk factor changes in the population over a ten year period. It was set up to explain the diverse trends in cardiovascular disease mortality, which were observed from the 1960s onwards, particularly a decline in CHD in the United States. Such trends are plainly apparent within MONICA. There is a total of 17 Centres in 9 out of the 15 European Union member countries (Belgium2, Denmark 1, Finland 1, France 3, Germany 3, Italy 2, United Kingdom 2, Spain1 and Sweden 2): there are 6 centres in 4 European third countries: Czech Republic, Lithuania, Poland, and Russia. Iceland (1 Centre) can be a partner and, therefore, eligible for funding, and Switzerland (1 Centre) is negotiating for similar status.There are a further 7 centres elsewhere in the world: 3 in Austral Asia, 2 in North America and one each in China and the former Yugoslavia. The 10 year data collection is now complete and the major 10-yearanalyses are underway. The completion of MONICA is supported through a grant under BIOMED 2 (PL951693) grant, which became available from 1 Ju
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Novel functionalization of liposomic nano-vehicles for strongly-enhanced drug delivery', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Delivery to diseased cells or tissues of therapeutic agents attached or encapsulated in nanoparticles – nanomedicine - presents many benefits, and comprises a rapidly-growing multi-billion-euro market. Lipid-based drug-delivery nano-vehicles, where drugs (not least the recent, very-widely-used, mRNA-based COVID-19 vaccines) are encapsulated in lipid vesicles (liposomes) or lipid nanoparticles, form a substantial part of that market. Nearly all FDA-approved liposomic vehicles are functionalized with poly(ethylene glycol), PEG, moieties, the current gold-standard. These act both to sterically-stabilize the vesicles, and, importantly, increase their blood-retention time and thus their therapeutic efficiency. At the same time, such PEGylation has several drawbacks, including reduced cellular uptake, accumulation of PEG in tissues, and accelerated blood clearance on repeated intravenous dosage due to heightened immune response. We use novel functionalization approaches to overcome these drawbacks.  The present project explores the innovation dimension of our new approach. In particular, is it effective? is it efficient? How widely applicable is it? What is the IPR position for future exploitation of this new strategy? These questions illustrate the high-risk/high-gain nature of this proposal, and are addressed here through several inter-related work packages. Success of our project in demonstrating that our novel approach is significantly superior to the current universally-used PEGylation would not only have a therapeutic advantage for many diseases, but also tap into a large and growing market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Regional validation of meris chlorophyll products in north sea coastal waters', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

REVAMP aims at supporting the monitoring of the eutrophication state of the North Sea by measuring and validating a key bio-geo-physical parameter (Chlorophyll or CHL concentration) using MERIS observations. Because of regional variations in North Sea water composition, REVAMP will develop and validate regional CHL products . The end product will be a North Sea atlas for the period spring 2002 to spring 2003, containing CHL maps, accuracy products and Added Value Products (e .g. monthly mean values). A selection will be made of state-of-the-art bio-optical models and analytical algorithms. Selected algorithms will be adapted for regional use. REVAMP will do high quality in-situ sampling for the purposes of parameterisation, calibration and testing of algorithms and for validation of the end products .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Energetics, Mechanism and Structural Characterisation of Protein-Protein Interactions by Computational Docking Simulations' (2002-2006).

assistant: **Concept**

Formation of specific protein-protein complexes is an essential requisite for most of biological processes, and constitutes one of the most relevant unsolved theoretical problems. Although several docking methods for abinitio prediction of protein-protein association have been reported, their systematic application at proteomic scale is still challenging.Difficulties arise from both the definition of the scoring function and the complexity of conformational changes upon binding. An important step to solve this problem is the use of (1) docking simulations by Monte-Carlo techniques (pseudo-Brownian movements and Biased Probability minimization) and (2) soft potentials pre-calculated on a 3-D grid.Based on this strategy, the candidate has developed, during his research work at The Scripps Research Institute (La Jolla, USA) and the University of Cambridge (UK), an accurate and efficient docking algorithm and several computational tools to predict protein-binding surfaces.The application of these methods to large databases of structures (generated by structural genomics projects and by homology modeling), together with the integration of biophysical data and genomic information, will facilitate the structural characterization of protein-protein complexes at a proteomic scale.The proposed project will have the following specific objectives:- development and optimization of computational predictive methods for their high-throughput application to PDB structures and homology models (generated at different resolution levels);- creation of a comparative database of protein-protein interactions in order to understand the structural and sequence factors that determine complex formation in proteins;- biophysical and computational characterization of protein-protein interactions of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'PALAS - Powerline as an Alternative Local AcceSs' (PALAS), addressing dissemination and exploitation.

assistant: **Impact**

Power Line Communications, PLC, is a recent and rapidly evolving technology, aiming at the utilisation of the electricity power lines for the transmission of data. PLC technology opens up new opportunities for the mass provision of local, last- mile access at a reasonable cost. The PALAS project aims to develop and test a complete service and commercialisation package to potential players in the PLC market. This package comprises technical simulation and consulting tools, initial business and turn-key service models as well as concrete roll-out strategies. In addition PALAS will provide a complex and coherent approach to reduce time to market and to increase certainty on market, technological, organisational and economic issues. Thus, the project will support a quick and sustainable development of a market segment that will become a major infrastructure for the development of the Information Society in Europe.Objectives:Although there is a large potential in developing and exploiting the PLC technology, a number of issues have to be challenged. Only an integral approach, covering technical, economical and organisational aspects is appropriate to help new players to overcome current obstacles. It is the objective of the project to develop a framework for the fast development and the market orientated implementation of the PLC technology. This requires to meet the following four major goals: providing a clear projection of the PLC market potentials, providing a basis for the evaluation of technological developments, defining and implementing a set of PLC specific services, and organisational implementation of PLC business models. Only the parallel discussion and implementation of all these aspects will help new market players to implement PLC quickly and to shape PLC as a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hippo signalling Pathway in Endosymbiosis' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The rice weevil Sitophilus oryzae is a pest insect which can cause major damages to cereal crops worldwide. S. oryzae hosts an endosymbiont, the intracellular gram-negative bacterium Sodalis pierantonius, which produces amino acids necessary for the host’s cuticle thickening. This biological interaction, called nutritional endosymbiosis, generally increases the weevil’s fitness, for example as a thicker cuticle protects the host against desiccation. Consistently, the bacterial load in S. oryzae has been shown to fluctuate throughout the development, with a peak in young adults, at the same time as cuticle thickening. However, maintaining endosymbiotic bacteria also constitutes an energetic cost for the host, and after the peak in young adult weevils, S. pierantonius load decreases. As the endosymbiont is present in specialised cells (i.e., bacteriocytes), organised in organs (i.e., bacteriomes), regulation of S. pierantonius load relies on a strong coordination between the two partners. The HipPiE project aims at investigating further the regulation of the endosymbiont dynamic, in order to find new sustainable strategies for pest management, using symbiosis disruption. By using dual transcriptomics at different developmental stages in S. oryzae, a recent study from the host team showed that several genes from the Hippo signalling pathway were differentially expressed in young symbiotic adult weevils as compared to weevils with no endosymbiotic bacteria (aposymbiotic weevils), suggesting a role of this pathway in the endosymbiont dynamic. The Hippo signalling pathway is involved in several biological responses like growth, cell differentiation, cell death, and tissue regeneration. However, its role in endosymbiosis has not been studied yet. During this project, we will s