RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'JWST Breakthrough in Galaxy Formation: Mass Build-up Efficiency at Cosmic Dawn'.

assistant: **Concept**

We present SFEER (Star Formation Efficiency in the Epoch of Reionization), an ambitious project to enable one of the most significant and long-lasting leaps in our understanding of early galaxy formation. The discovery of exceptionally massive galaxies in the distant Universe has confronted us with puzzling questions about how galaxies could assemble so efficiently at early cosmic times. Unfortunately, significant instrumental limitations have prevented us from robustly reconstructing their physical properties. The recent launch of the James Webb Space Telescope (JWST) has ignited a revolution. Its exquisite sensitivity and spatial resolution are going to provide dramatically new information on massive galaxies in the the Epoch of Reionization (EoR) and beyond. SFEER is set to play a dominant role in this process. At its core is a cycle 1 JWST/NIRSpec program I am leading which will obtain spatially resolved spectroscopy for 12 exceptionally bright galaxies in the EoR. Remarkably, estimates of the interstellar medium (ISM) reservoirs of this sample are already in our hands thanks to recent Atacama Large Millimeter Array (ALMA) observations, providing information on their molecular gas and dust content, and the fraction of obscured star formation. This joint dataset clearly stands out in the panorama of current JWST programs, and constitutes an important benchmark. SFEER will enable to probe the assembly history of these tantalizing objects through the characterization of their ages, stellar mass, energy-balanced star-formation rates, metallicity, merging fractions and gas kinematics, and their relationship with the host dark matter halos. Taking advantage of complementary JWST programs and wide-area multi-wavelength data from ground and Euclid, we will extend our result
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'HYDROGEN HAZARD PASSIVE AUTOCATALYTIC RECOMBINERS STATE OF THE ART' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

This thematic network consists of performing the state-of-the-art of passive autocatalytic recombiners, which represent the best solution in mitigating hydrogen hazard.The main purposes of this work are:1) to expand knowledge about PARs among the main users;2) to built up a large synthesis on such devices;3) to assess PAR applications in different fields such as small fission reactors, nuclear and conventional fields. This work will be carried out by an EU work group including the main players in this area like recombiner manufacturers, safety authorities, research experts, nuclear power plant designers and utilities. Five reports will be written by the co-ordinator and approved by partners (preliminary report, intermediary report, yearly progress report, final public report, final report for partners).Environmental safety of nuclear power plants may be severely affected by uncontrolled hydrogenoxygen reactions in-case of severe accidents. The introduction of passive autocatalytic recombiners is an interestincr method to remove together hydrogen and oxygen. This thematic network consists of performing the state of the art in passive autocatalytic recombiners, which seem nowadays to represent the best solution in mitigating the hydrogen hazard. The main purposes of the work are: - to expand knowledge about passive autocatalytic recombiners among the main users,- to build up a large synthesis on such devices in order to create an aid tool for users,- to assess PAR applications in different fields (fission or fusion reactors, chemical industry). This. work will be carried out by a EU workgroup including the main actors in this area like recombiner manufacturers, safety authorities, research experts, nuclear power plant designers and utilities. Three reports will be written
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Non-equilibrium phenomena in complex systems - a microscopic approach', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Structures emerging in systems out of equilibrium are in general of greater complexity and variety than their equilibrium counterparts. This wealth of be- haviour is both the reason for current interest in the field and the source of dif- ficulties in the analysis of non-equilibrium phenomena. We propose to study a class of model systems with simplified microdynamics (lattice gas automata) in order to investigate the meso and macroscopic behaviour of spatially extended systems under non-equilibrium constraints. Lattice gas automata exhibit features that make them well-suited to model these complex systems under both equi- librium and non-equilibrium conditions: They possess a large number of degrees of freedom, they are non-linear and, furthermore, they exhibit spontaneous fluc- tuations. Their discrete nature facilitates the computational implementation of their dynamics, making it possible to investigate large systems, and yielding ac- cess to quantities that are hard to obtain in experiments or from other theoretical approaches. As a prototypical system, we shall analyze theoretically and numeri- cally a thermal lattice gas automaton to investigate the appearance of long-range correlations in a fluid subject to a temperature gradient, away from critical points and hydrodynamic instabilities. We further investigate the properties of the dis- tribution of temperature fluctuations in such a fluid, when both a temperature gradient and turbulence are present. The results of these simulations will be com- pared to experiments and also to stochastic models, which include the effects of fluctuations in a phenomenological manner.  This proposal is intended as a continuation of current research being carried out by the applicant under a EC 'Human Capital and Mobility' fellowsh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Intracellular Methylases Delivery as therapeutic tool for carcinoma specific regulation of Gene expression.' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The goal of this CRAFT consortium is the generation of a prototype of a new generation of drugs, which are based on the combination of established technologies in the field of protein engineering, DNA-targeting and drug delivery. The combination of the diverse fields of technology is very innovative and a reachable task. As prototype we aim for a double targeted therapeutic compound which is a carcinoma cell specific delivered and carcinoma gene specific in his DNA-methyltransferase activity which can switch the expression of a tumour-associated gene involved in carcinogenesis expressed in 40% of all human tumours, from on to off. Cancer is the second cause of death in the Western world and continues to emerge at an accelerated rate in the developing countries as well. Although progress has been made in the therapy of some types of cancer, the overall survival prognosis with current standard therapy is poor. Therefore, new treatment strategies are needed. The approach we propose here is based on the selective silencing of the epithelial glycoprotein-2 (EGP-2) gene, which is abundantly expressed in a variety of carcinomas, counting for 40% of all cancers. The goal of the proposed method is to selectively silence the EGP-2 gene by targeted methylation of the EGP-2 promoter. The therapeutic compounds we wish to develop consist of a targeted DNA methyltransferase and a targeted delivery system, based on synthetic amphiphiles, specific for EGP-2 positive cells. The targeted DNA-methyltransferase is a covalent complex of a triplex forming oligonucleotide (TFO) and the CpG-specific DNA methyltransferase M.SssI. This TFO-M.SssI conjugate has the potential to methylate a unique CpG site in a genome. Because of the high targeting specificity of the envisaged product, the proposed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Understanding the infection by the bacterium Listeria monocytogenes as a way to address key issues in biology' in the context of a Seventh Framework call.

assistant: **Objectives**

Host-pathogen interactions have recently received much attention. Yet, a more comprehensive understanding of these interplays should provide fundamental advances in biology and help generating new therapeutics. The intracellular bacterium Listeria monocytogenes has emerged as an exceptional model organism to address key questions in biology such as actin-based motility, phagocytosis and post-transcriptional regulation. We will exploit our deep knowledge of Listeria and use this bacterium as a model to explore new landmarks in biology.In that aim, we will analyze several aspects of the infectious process, in a spatio-temporal fashion, at the bacteria, cell, tissue and host levels. Specifically, we will 1) search and analyze the function of new non-coding RNAs involved in virulence, and of new RNA-mediated regulations; 2) investigate new facets of bacterial entry and cell-to-cell spread in particular the role of uncharacterized cytoskeletal components, septins; 3) address the role of mitochondria and their dynamics in infection; 4) systematically analyze post-translational modifications during infection, starting with SUMOylation, a reversible modification and proteolysis, an irreversible one; 5) investigate chromatin remodeling upon infection; 6) characterize new virulence factors identified by their interaction with known signaling components or cellular sensors, by post genomics or by their effect on cellular responses analyzed herein ; 7) investigate further the intestinal phase of Listeria infection by analyzing in the germ-free transgenic mouse that we generated, the impact of commensals on Listeria (growth and transcription including non-coding RNAs) and on the intestinal tissue (histology and transcription of genes and microRNAs).Our main goal is to improve signif
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Searching for Dark Matter in the Higgs boson sector with the ATLAS detector' (DarkMatterAndHiggs).

assistant: **Innovation**

According to modern cosmological models only 16% of all matter in our universe corresponds to the known, visible matter. The other 84% is called dark matter (DM) and could so far only be observed indirectly, which is why its particle nature is poorly understood. Yet, DM played a crucial role during the evolution of our universe and thus the formation of life itself. Therefore, the understanding of DM is an important aim of contemporary physics and is pursued in this fellowship.With this research proposal, I will endeavour to uncover the particle nature of DM by analysing the proton collisions of the Large Hadron Collider recorded with the ATLAS detector at a centre of mass energy of 13 TeV. I will study whether DM is produced in the collisions by analysing events containing a Higgs boson decaying to two tau leptons and missing transverse energy, the iconic signature of weakly interacting particles. This search channel has not been exploited before and complements the current searches for DM performed by the ATLAS collaboration. I will develop a strategy to identify these Higgs decays by using novel physics quantities and machine learning methods. The results will be interpreted in different models that describe DM.Furthermore, I will combine the results of different Higgs plus DM searches of the ATLAS Collaboration to maximise their discovery reach. Their sensitivity will be increased through the exploitation of the uncertainty correlation between the different measurements and results from other DM searches will be incorporated. This way, my proposal connects the fields of high energy physics, astroparticle physics, cosmology and computer science with the aim to uncover the true nature of DM in our universe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Tailored technologies for the development of next-generation PROTAC molecules (DEGRON)'.

assistant: **Concept**

PROTACs (Proteolysis-Targeting Chimeras) are a groundbreaking class of novel therapeutics capable of targeting disease-causing proteins previously thought to be undruggable. They work by recruiting E3 ligases to ubiquitinate target proteins, leading to their degradation. However, despite their promise, current PROTAC design is severely limited, relying on only two out of 613 E3 ligases. In addition, PROTAC development remains slow, inefficient and heavily reliant on trial-and-error approaches.The DEGRON project aims to revolutionize PROTAC drug discovery by commercializing key innovations originally developed in our ERC Starting Grant. First, we developed a patented high-throughput screening system to systematically identify the optimal E3 ligase for any given PROTAC target, enabling rational drug design. Second, we established real-time in vivo systems that enable target validation and precise measurement of PROTAC activity, replacing inefficient endpoint assays and reducing animal use and costs by over 70%. These innovations lay the foundation for a scalable drug discovery platform that transforms PROTAC development into a systematic and predictive process.Our commercialization strategy is two-pronged:1. Provision of DEGRON services: We plan to establish a company offering PROTAC screening and validation assays to both academic and industrial customers. Over time, our goal is to offer the full PROTAC development pipeline as a one-stop-shop.2. Development of proprietary PROTACs: We are currently advancing our own PROTAC pipeline under an ERC Consolidator Grant, focusing on therapeutics for pancreatic cancer. These preclinical candidates will be integrated and further developed within DEGRON and progressed towards clinical application. This ERC-PoC study will facilitate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Technology transfer of application protocols, standards and health/safety criteria for the use of spray drying technology' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

This Concerted Action specifically addresses the spray drying industry and its applications. Spray drying is an important processing technique, widely used in a number of processing industries, including the food, pharmaceuticals, agrochemicals bulk and fine chemical industries. It is also used in the production of technical ceramics and in the control of acid rain from coal-fired power stations. Optimisation of spray drying in these industries is often limited by a lack of basic scientific understanding. This is particularly true in the food industry, targeted by this network primarily because there is a prevalence of SME's in this industry who do not have access to the latest technologies. This network proposes to overcome this problem by identifying and transferring new technologies from the research level to the industrial field by coordinating ongoing research activities with the member organisations, funded within member states.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Magnetic Biomaterials: Magnetically Loaded Stem Cells as Diagnostic and Therapeutic Vectors for Lung Cancer' (BIOMAG) under Seventh Framework.

assistant: **Objectives**

Lung cancer is the most lethal cancer in the world today. There are limited options for clinicians when treating patients, with only 10-15% of lung cancer patients surviving their malignancy. Despite the introduction of new chemotherapies, lung cancer survival is unchanged from thirty years ago. New ways of treating this disease are needed. We hypothesise that modified mesenchymal stem cells (MSCs) may be used to deliver magnetic nanoparticles through their engraftment, killing both tumour epithelium and tumour vasculature, while preserving normal tissue. We propose to introduce bio-compatible tailored magnetic nanoparticles into the MSCs to enable localised cellular-level sensing and heating while retaining the full viability and functionality of the MSCs. We will examine the kinetics of MSC engraftment and compare histological samples to in vivo quantification of engraftment using contrast-enhanced small animal magnetic resonance imaging (MRI) based on sensing the MRI signal of the introduced nanoparticles. MSCs will subsequently be locally heated by applying a time-varying electromagnetic field to induce heating of the nanoparticles (a process similar in principle to that used in microwave ovens) and consequent tumour destruction. MSC delivered therapy is particularly attractive. MSCs are easy to culture, expand and genetically manipulate. They are immuno-privileged, and also home preferentially to tumour tissues allowing systemic delivery to widespread tumour and metastases. As such they offer a uniquely bio-compatible, patient-derived therapeutic solution to the life-threatening disease of lung cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Intercommunal Space in Late Antiquity', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Educated Europeans hotly debate the position of religion in civil society, both in Europe and now in the emerging democracies of the Middle East. In so doing, they draw on inaccurate assumptions about Mediterranean life in late antiquity, which derive from origins myths forged during the Enlightenment or during the 4th-7th c. itself. But recent work on cities in this period has revealed a society more complex than previously supposed: religious co-existence, as much as conflict, was an important reality. Yet, whilst the history of urban religious space is now being revised, there has been little work on intercommunal space, which was equally important in defining how different communities lived together. Luke Lavan, a specialist in the urban archaeology of late antiquity, will spend two years in Paris researching this theme, resulting in a monograph, whilst sharing with scholars and the general public his innovative fieldwork, tracing the late occupation of non-religious space, alongside his detailed visualisations of everyday urban life. The Centre d'Histoire et civilisation de Byzance, UMR 8167 (‘Monde Byzantin’) has an exceptional concentration of specialists, in archaeology, philology and epigraphy, to support the research. To this, LL will bring skills to enhance the understanding of archaeological excavations and of the everyday details of ancient texts. Above all, the action will produce a balanced view of late antiquity, pointing out its positive contribution, as an ancestor of European society, to the art of living together, despite our differences.