RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Next generation small-scale biomass combustion technologies with ultra-low emissions' under Seventh Framework.

assistant: **Concept**

The UltraLowDust project aims at the demonstration of an European approach for ultra-low emission small-scale biomass combustion based on three novel technologies which cover the whole range of residential biomass heating applications. For pellet and woodchips combustion a new ultra-low emission boiler technology operating at almost zero CO, OGC and PM emissions will be demonstrated. Moreover, a new stove technology based on optimised air staging and an automated control system which shows significantly decreased PM, CO and OGC emissions compared with present stoves will be introduced. For PM emission reduction in old and new logwood boilers, old stoves as well as boilers for non-wood biomass fuels, a new ESP system will be demonstrated. These three technologies shall after successful demonstration define a new state-of-the-art regarding ultra-low emission biomass combustion covering an intelligent combination of primary and secondary measures. The technologies will be demonstrated within field tests over two heating seasons. Moreover, the project aims at the development of market introduction plans for the new technologies which will be supported by a market study as well as techno-economic analyses and overall impact assessments based on the results of the field tests. Additionally, the project aims at the development of recommendations for future emission limits under consideration of the results achieved, which shall then be discussed with national and EU authorities active in legislation making. To reach these aims a consortium of partners from 3 EU-countries consisting of the manufacturers of the three key technologies, research institutions which will support the industrial partners with their expertise in biomass combustion, one partner who is active in the fiel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Improving Diagnosis by Fast Field-Cycling MRI' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Many diseases are inadequately diagnosed, or not diagnosed early enough by current imaging methods. Examples of unmet clinical needs arise in thromboembolic disease, osteoarthritis, cancer, sarcopenia, and many more areas. Our solution, Fast Field-Cycling (FFC) MRI, can measure quantitative information that is invisible to standard MRI. FFC scanners switch magnetic field while scanning the patient, obtaining new diagnostic information. FFC-MRI has been demonstrated by us, but many challenges must be solved before clinical adoption.Objectives:Understand the mechanisms determining FFC signals in tissues;Create technology to measure and correct for environmental magnetic fields, enabling FFC at ultra-low fields;Investigate contrast agents for FFC, to increase sensitivity and to allow molecular imaging;Improve FFC technology, in order to extend its range of clinical applications;Test FFC-MRI on tissue samples and on patients.Achieved by:Developing the theory of relaxation in tissue at ultra-low fields, leading to models and biomarkers;Developing magnetometers for FFC-MRI, and environmental-field correction;Creating and in vitro testing of new FFC contrast agents; studying existing clinical agents for FFC-MRI sensitivity;Improving technology to monitor and stabilise magnetic fields in FFC; improving magnet power supply stability; investigating better radiofrequency coils and acquisition pulse sequences;Testing FFC methods on tissue samples from surgery and tissue banks; proof-of-principle scans on patients.FFC-MRI is a paradigm-shifting technology which will generate new, quantitative disease biomarkers, directly informing and improving clinical diagnosis, treatment decisions and treatment monitoring. Its lower cost contributes to healthcare sustainability. The proposal cons
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Safe Food Enhancement System' (SAFES).

assistant: **Innovation**

Trial the integration of an existing prototype with standard web browsers to provide user friendly access to remote client/server software. The prototype was previously developed for use with real time data collection to improve HACCP-based food safety and quality objectives.Adds value by automating SME day to day operational management using existing data gathering devices to ensure improvements are analysed with the use of data models which will also create smarter practice to achieve rapid training of personnel, reduction of process and team times, improve due diligence by building it into the system and aid Community objectives by improving best practice software solutions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mitochondrial calcium signalling: molecules, roles and pharmacological targeting' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Mitochondrial Ca2+ homeostasis is an important component of the calcium-mediated cellular response to extracellular stimuli. It controls key organelle functions, such as aerobic metabolism and the induction of apoptotic cell death, and shapes the spatio-temporal pattern of the cytosolic [Ca2+] increase. While its physiological and pathological relevance is now fully appreciated, lack of molecular insight has severely limited mechanistic understanding and pharmacological targeting. We have now identified the long sought “mitochondrial Ca2+ uniporter” (MCU). This project stems from this ground-breaking result, and with a multidisciplinary approach investigates the biological role of MCU, tackling also its structure/function relationship and possible pharmacological exploitation. Specifically, the project will be divided in five major tasks: i) the elucidation of the subcellular distribution of MCU and of the supramolecular organization of the mitochondrial Ca2+ influx machinery; ii) the clarification of the cross-talk with other signaling pathways, with major focus on regulatory mechanisms based on post-translational modifications (phosphorylation, acetylation, oxidation); iii) the development of suitable heterologous systems, in which wild-type MCU or mutants can be expressed; the purified protein (or the isolated mitochondria) will be utilized in electrophysiological studies to investigate the functional properties of the channel; iv) the elucidation of the protein structure, with the aim of developing specific inhibitors, based on molecular modeling and crystallization of the protein produced in the appropriate heterologous system; v) the generation of conditional and tissue-specific knockout models for investigating MCU function in vivo; the analysis of the phenotype,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sensitisation and resistant determinants of cancer cells to death receptor related therapies' (ONCODEATH), addressing dissemination and exploitation.

assistant: **Impact**

In the last decade, an encouraging decline of the death rate from cancer has been observed, as a result of recent advances in prevention, early diagnosis and therapy. Efforts are made towards the generation of smart" anti-cancer drugs that will target specific molecules depending on the molecular phenotyping of the patient's tumour. TNF-related apoptosis-inducing ligand (TRAIL) is currently a promising anti-tumour agent with proven activity on several cell and animal cancer models. A unique feature of TRAIL is its specificity towards malignant cells while sparing normal cells. At present, pre-clinical studies with recombinant TRAIL are in progress as well as with an anti-TRAIL-R2 monoclonal antibody with no hepatotoxicity.The aim of the present proposal is to identify components in colon tumours which confer sensitivity or resistance to cell death induced by TRAIL. This project is based on recent findings that oncogenes like RAS or MYC sensitise cells to TRAIL induced apoptosis. For this purpose, human cancer cells a) bearing oncogenic mutations, b) overexpressing oncogenes and c) silencing mutated forms of oncoproteins by RNAi or homologous recombination will be utilised.In order to identify specific cell death determinants induced by KRAS, BRAF and PIK3CA oncogenes, examination of specific pathways like B-RAF, MEK, PI3K, Rho, BCL-2 will be performed. Studies will be further extended to animal models of tissue specific K-ras induced carcinogenesis. Combined action of TRAIL with other therapeutic molecules will be utilised, in order to succeed optimum effects with minimum concentrations and toxicity. The potential findings of our study will be determined by the present research network and will provide mechanistic basis for a pharmacogenomic approach which could be furt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Sustainable Silks Programme' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Silks are fully sustainable, non-perishable and climate-smart agricultural products.  They are uniquely suited for areas of low-wage/high-unemployment and fragile ecosystems sensitive about water and soil.  At the same time, silks and silk-derived materials are used for simple as well as highly sophisticated applications and products with low to high potential for adding value with rather moderate investment.The Oxford Silk Group’s research on the ERC funded “Silk as Biomimetic Ideals for Polymers” led to a number of novel and important insights that combine proprietary know-how with patented concepts.  A key invention allows a wide range of novel silks to be accessed - thus freeing the global industry from the heavy reliance on mulberry silks and adding novel wild silks to the market.  This, together with other original insights and innovations, and combined with Silk ‘Life Cycle Analysis’ allows now the planning and execution of novel silk projects in an economically robust as well as environmentally sustainable way.Our unique selling points are: (1) our Oxford research group is one of very few market leaders globally in the field of R&D on silks and has (2) unique insights in wild silk IP, in addition to (3) a pipeline of novel, sustainable silk products combined with (4) proprietary LCA models developed from silk farms around the world and derived from a rapidly developing and extensive network of collaborators.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Why do cancers occur where they do? A genetic and evolutionary approach.' (EVOCAN).

assistant: **Innovation**

Tumorigenesis is a form of somatic evolution, a topical subject given the advent of cancer genome sequencing. However, we contend that some features of Darwinian evolution have been neglected when cancer is studied, as have some aspects of evolution that are special to cancers. For example, tumours comprise an expanding population of cells, cancers must occur within a normal human lifespan, and genotypes detrimental to growth of the tumour as a whole may be selected. These factors may render invalid the classical model in which successive mutations with large advantages arise and  spread through the tumour in selective sweeps. To incorporate these neglected features and to test how tumorigenesis depends on factors such as mutation rate, selection and size constraints, we shall set up a comprehensive model of tumour growth incorporating cell birth, death, division and mutation parameters. We shall examine specific aspects of cancer-as-evolution in mice. By marking mutant clones using fluorescent proteins, we can track them and see how they persist, spread and die. We shall also determine the mutation profiles and genetic diversity of mutant clones and whole tumours in mice and humans using next-generation sequencing. Specific experiments will determine: (i) the fate of new advantageous clones arising in an existing tumour; (ii) whether new disadvantageous clones can persist in tumours; (iii) whether apparently maladaptive traits for tumour growth, such as suppressing the growth of competitors, can be selected; (iv) why do housekeeper gene mutations cause cancer in specific sites; (v) can cancer cells have too much genomic instability; and (vi) whether all cancers develop owing to driver mutations with big effects, or are there “mini-drivers” of tumorigenesis? There will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New sustainable, functionalized and competitive PHB material based in fruit by-products getting advanced solutions for packaging and non-packaging applications' in the context of a Seventh Framework call.

assistant: **Objectives**

The EU fruit juice and nectars market stood at a healthy 11.3 billion litres in 2009. A 60% of total volume consumed is packaged with carton, a 25% with PET and the remainder is packaged with glass (13%) and other packaging formats (2%).Environmental sustainability concerns are rising on the public agenda, becoming even more relevant to the consumers.The EU juice and nectars industry is aware of its important role and responsibility, making use of best practice which involves full LCA to reduce both carbon and water footprint.Juices and nectars producers have sought to provide the most environmentally friendly packaging available.Meanwhile, packaging innovations is getting ahead of developments in recycling.It is illogical that VAT as high as 20% to 25% can be applied to packaged fruit juice.There is a need to join efforts between packaging companies, recycling operators and governments to maximise the latest technology.The use of conventional polymeric materials petrochemical – based in packaging, represents an important environmental impact and waste generation due to their non-biodegradability. Some alternative materials obtained from renewable resources can be found in the market. These materials fulfil the environmental concerns but they show some limitations in terms of performance like processing by injection and thermal resistance joined to high associated costs. This situation makes necessary research to improve their added value.The aim of PHBOTTLE project is to develop a new BOTTLE (body, cap & sleeve) from biodegradable material, concretely PHB, which will be obtained by fermentation of wastewater from juice processing industries (renewable biogenic resource); optimising eco and energy efficiency in the material production and processing. The new bottle will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Astrochemistry and chemistry emulation to simulate dust formation and growth around evolved stars' (ASHES) targeting Horizon Europe.

assistant: **Abstract**

The chemical evolution of galaxies is driven by mass loss from stars at the end of their lives. The majority of stars will go through an asymptotic giant branch (AGB) phase, losing their outer layers by means of a stellar outflow and enriching the interstellar medium with the building blocks for the next generation of stars and planets. The outflow is triggered by stellar pulsations that aid dust formation, which then launches a dust-driven wind. Large-scale structures, like spirals and disks, are widely observed and thought to be caused by binary interaction with a (sub)stellar companion.Despite the importance of dust to launching the outflow, we still do not know exactly how it is formed. Dust formation is a fundamentally chemical process: gas-phase molecules form larger clusters, condense into a seed particle and grow by accreting more molecules. Existing dust formation models either assume an initial number of seed particles to be already present at the start of the model or use classical nucleation theory, which is not applicable to AGB outflows as it assumes thermal equilibrium. Now, thanks to a decade of quantum chemical calculations, it is finally possible to model dust formation in a chemical kinetic way in AGB outflows. ASHES will develop the first comprehensive chemical network that includes dust nucleation and growth, allowing us to quantify the effects of large-scale structures and a stellar companion’s UV field on the amount, composition, and size of the dust.Using machine learning to emulate the network, we will build the first comprehensive 3D hydrochemical model. This model will quantify the impact of a binary companion on shaping the outflow and, for the first time, on the chemistry and dust formed within the outflow. The observational tracers generate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'CreAting NonconventionAl Laminates' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The purpose of the CANAL project is to develop new Non-Conventional Laminate (NCL) configurations using Dry Fibre Placement (DFP) and the establishment of engineering tools to ensure implementation of the technology in the aerospace industry and other industries, such as automotive that can benefit from rapid and cost effective production of complex shaped and high-performance composite parts. Whereas up to now composite laminates usually consist of only 90, 0 and +/-45 degree layers, the development of Automated Fibre Placement technology has opened possibilities to divert from this limiting step in design and manufacturing. Currently, no non-conventional laminates are known to be implemented in the industry, though research has shown promising results in virtual analysis and coupon testing. Variable stiffness laminates with curved fibre paths show an increase in buckling loads, as well as tailoring of natural frequencies for both panels and cylinders. Straight-fibre laminates with dispersed fibre angles show a promise for improved damage tolerance. A so-called AP-PLY multidirectional weave pattern can improve damage tolerance for any stacking sequence. Whereas for large aircraft manufacturers like Airbus and Boeing it almost seems default to use composites and a high level of automated fabrication with e.g. AFP, it is also lucrative for the small aircraft industry and the transport industry in general. Both weight and cost reduction can be achieved using automated composite manufacturing like AFP. Further material cost reduction are achieved through use of dry fibres instead of more costly prepregs, in combination with Liquid Composite Moulding instead of costly autoclave curing. The reduction in weight and cost supported by novel non-conventional design and dry fibre