RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mechanisms of control of e. coli sigma factors involved in stress gene regulation' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content Regulation of bacterial responses to stress often involves control of activity and stability of sigma factors. This project aims to dissect such regulatory mechanisms using E. coli sigma32 and sigmaS. Sigma32 controls heat shock genes encoding chaperones and proteases. Heat shock increases stability and activity sigma32 thereby increasing expression of heat shock genes. The DnaK and DnaJ chaperones mediate this regulation by stress-dependent association with sigma32 thereby repressing its activity and controlling its degradation by the protease FtsH. SigmaS controls general stress genes which protect cells from starvation damage. Starvation prevents sigmaS degradation by the ClpXP protease in a DnaK-dependent process. For both sigma factors genetic evidence suggests that control of their stability and activity requires short segments within the sigma32 and sigmaS polypeptides that are in similar relative position. Using genetic and biochemical tools it will be investigated whether these segments represent regulatory modules. It will then be attempted to identify residues which are essential for protease and ligand (DnaK, DnaJ) recognition. Identification of the recognition principles are relevant to the understanding of other stress regulations involving similar control mechanisms of sigma factors (e.g. SigB in B. subtilis) and eucaryotic transcription factors (e. g. . heat shock transcription factor). Training content (objective, benefit and expected impact) The planned project is expected to identify molecular principles governing the regulation of two important stress responses in E. coli. The results may serve as a paradigm for understanding other stress responses in bacteria and the heat shock response in eucaryotes. It may also allo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Rechargeable Telemetry-Based Electrochemical Sensors: Kidney Oxygenation and health' (ReTeBESKO).

assistant: **Concept**

Translational research for human health on major diseases such as cancer, cardiovascular disease, diabetes and obesity requires modalities that can monitor an ever widening spectrum of physiological signals over extended periods of time in animal models unhindered by anaesthesia or restraint. We hypothesize that a novel generation of in vivo rechargeable, telemetry-based electrochemical sensors will facilitate continuous recording of a hitherto uncharted spectrum of signals in different tissues and thereby will hugely improve testing and validation of new drugs as well as our understanding of physiology and pathophysiology.Elucidating the link between renal oxygenation and kidney health, will have major impact in the clinical practice, making it a very promising and timely subject. To allow such a breakthrough this proposal will start with the realisation of a telemetry-based solution for chronic measurement of oxygen in the kidney.This inherently multidisciplinary project will partner with the University of Auckland, a leading site in biomedical engineering, for the development and testing of novel telemetry devices. In acute experiments surgical methods and hardware will be refined and tested before progressing to experiments in conscious animals. Thereafter renal oxygen will be continuously recorded in an accepted rat model of chronic kidney disease without and with therapy to confirm disturbed oxygen homeostasis and to evaluate treatment efficacy.This fellowship will not only generate groundbreaking technology, knowledge and expertise to study kidney oxygenation, but it will also allow me to be at the forefront of a new area in physiology research. On my return to the home institute we will be able force breakthroughs within the European Research Area for mechanisti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project ''Use It Up, Wear It Out, Make Do or Do Without'. Reuse, Repair and Recycle in Late Medieval Italy (13th-15th centuries)' (ReLMI) under Horizon Europe.

assistant: **Objectives**

My project aims to produce the first social and economic history of cast-offs management and conversion and reuse in late medieval Italy through the analysis of three case-studies, Fabriano, Florence and Bergamo and their hinterland. By examining the circulation of cast-offs in medieval crafts, identifying practices of reuse, repair, recycling and upcycling, as well as by discovering networks of waste management, this project seeks to suggest that certain crafts eventually become embedded practices in the urban economy of late medieval Italy. My aim is to demonstrate that in medieval urban society, where raw materials were expensive and profit margins tight, the re-employment of scraps and by-products was an essential part of craft strategy. The goal is to verify that general economic growth and rise of consumption at the end of the Middle Ages stimulated the use of waste and recycling, and therefore, alternative forms of production to those traditionally employing raw materials. Academic research in the fields of archaeology, material culture, and, more recently consumption has rarely used historical data and material findings together, and generally have considered each element of reuse, repair, and recycling in isolation. My project on Italy in the Middle Ages instead examines all three elements of reuse, repair, and recycling by looking at previously unexplored and unpublished documentary evidence combined with data coming from archaeological surveys and GIS web resources. This will assist in the reconstruction of the technological, economic and social processes that turned cast-offs into complex and tradeable commodities. The cycle of waste, the key role of artisans and producers, their guilds, and on the foreground, institutional policies in cast-offs management w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Agoprene - biofoams for the future furniture', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Agoprene develops furniture foam from biomass to help the furniture industry reduce the need for petrochemicals. By combining biomass from plants such as seaweed and wood waste, we have developed a furniture foam with zero petroleum. The idea came to life in November 2019, after a long research within the field of biomaterials. We learned that petroleum is a by-product of degraded biomass over time (this might be common knowledge to others), and that this enables us to produce the same materials from plant-mass as petroleum. The end-product is somewhat different when composed from crude oil because it has been converted over geological time, but in principle we can make the same products. That is exactly what Agoprene is doing.


**Keywords:** bioinnovation, biomaterials, seaweed, bioplastic, foam
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quality engineering tools for assembly and small batches manufacturing' (QUETA).

assistant: **Concept**

IT solutions are needed by users to effectively support advanced Total Quality Management (TQM) concepts aimed at ensuring the zero defect objective at minimal cost. As the advanced TQM concepts are more sensitive to perturbations in manufacturing systems than traditional ones, they require effective preventative quality control (QC) and strong feedback loops in order to guarantee their efficiency. QUETA's objective is to develop new IT-based tools to support TQM in those areas which have not been sufficiently covered by adequate tools, specifically in the complex assembly area and flexible, small batches manufacturing with high model mixed production. The project addresses both product and process quality aspects in order to effectively support TQM concepts and the continuous improvement of product and processes in reference to ISO 9000 requirements, as well as the more strict norms of QS 9000 applied in the US car industry. Specifically, the objectives of the R&D activities in QUETA are to develop new approaches and tools for:- Quality focused analysis of assembly aimed at identifying/predicting critical components/dimensions/characteristics by error propagation techniques and probability based component analysis.- Error analysis of components, subassemblies and assembly in order to identify quality critical manufacturing and assembly processes, i.e. to identify the reasons for errors: the project is focusing on those areas where classical statistical approaches are not directly applicable (e.g. small batches manufacturing) and, therefore, innovative procedures/tools have to be developed, based on the identification of the common features of products to enable definition of quality critical processes (feature based sampling).- Generation of cost effective action plans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Best-Estimate Projections of Future Compound Extreme Heat, its Impacts and Driving Mechanisms' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In a warming world, extreme heat will become more likely, and more extreme. Extreme heat can lead to devastating socioeconomic and ecological impacts, especially when peak maximum temperatures occur together with other compounding stressors, such as high ambient humidity, lack of nighttime cooling, or persistent drought. When unprecedented record-shattering compound heat extremes occur, it raises the question of whether current climate models are able to sufficiently capture the risk and intensity of such unlikely but devastating extremes under present, and especially future climate conditions. Are climate model projections downplaying the risk and intensity of current and future heat due to missing or incorrect process representation? Can climate models sufficiently sample the most unlikely and extreme albeit still plausible events? And how would such utterly unlikely extreme compound heat develop? Which intensity, persistence, or compounding could it reach? These are the questions I will answer in TrueHeat, and by doing so I will produce the best-informed knowledge of the unlikely but plausible heat that we may come to experience in the near-term future, and how single instances of extreme heat can turn into their most devastating and unprecedented version.To do this, I will first exploit the vast amount of existing large ensembles from different climate models that allows me to curate best-estimate future heat and heat-impact projections using superior evaluation and performance-weighting frameworks. Then I will use climate prediction ensembles to assess where chance brings the largest heat intensification, while determining why forecasted black swan heat extremes did not occur, or occurred in a less extreme form in reality. Lastly, I will generate novel targeted boo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Oxalic acid from CO2 using Eletrochemistry At demonstratioN scale' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The OCEAN project aims to develop an integrated process for the production of high-value C2 chemicals from carbon dioxide using electrochemistry. This will be achieved by: 1) improving and optimizing a TRL5 technology that can convert carbon dioxide to formate, to TRL6. OCEAN will bring this technology just one-step away from commercialization, by demonstrating this technology at the site of an industrial electricity provider, converting 250 g of CO2 per hour at 1.5 kA/m2. The energy efficiency will be improved by coupling the cathodic reaction to the oxidation of glucose at the anode, using a novel technology to match the kinetics of the reactions at both electrodes. The obtained formate can be converted to oxalate. 2)Developing new electrochemical methodologies to further convert formate and oxalate to formic acid and oxalic acid, respectively. Novel salt-splitting will be investigated using bipolar membranes. Again, this allows for direct coupling with an electrosynthesis step at the anode and/or cathode. 3) Developing new electrochemical methodologies by converting oxalic acid to glycolic acid and other high-value C2-products, these will be benchmarked with conventional hydrogenation. 4) Integrating the TRL6 and new (TRL4-5) electrochemical technologies in an industrial process, aimed at the production of high-value C2 products and polymers thereof by developing the process steps needed to produce oxalate, C2 products and polymers. 5) Demonstrating the economic feasibility by performing a market analysis and making a business case and exploitation strategy. Overall, OCEAN aims at addressing the critical elements that are currently hindering new electrochemical processes by targeting high value products that have the corresponding production margin to introduce this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Artificial Placenta (ArtPlac) - Miniaturized Integrated Lung and Kidney Support for Critically Ill Newborns' (ArtPlac) under Horizon Europe.

assistant: **Objectives**

This Pathfinder project will establish a radical change in the treatment of newborns using an artificial placenta (ArtPlac). What drives us towards a radical new treatment approach? 2 mio. neonatal deaths that occur worldwide yearly. The technological advancements of the last fifty years were based on scaling down adult devices which are not ideal for all babies. Why? Because babies are not just small adults! In fact, the applied treatments are very invasive and cause side effects by damaging their sensitive bodies. Survivors often suffer from life-long complications or cannot live independently. In utero, the placenta is a life-giving organ and serves as fetal lung, fetal kidney, and feeder. Because the placenta cannot be reconnected after preterm birth, we aim to continue the placental support with ArtPlac. Our novel device simply connects to the belly button for lung and kidney support while the newborn can breathe, mature, and heal. To achieve this, a novel compact and miniaturized all-in-one artificial placenta device combining lung and kidney functions will be developed. Our plug-in approach will use the natural umbilical vessels at the belly button with expandable catheters to provide a large bore vascular access like in utero. This allows ArtPlac to be driven solely by the newborn's heart like in the womb. Inline sensors will analyze blood parameters without painful collection. Feedback loops in ArtPlac will provide individual demand-driven support. Inbuilt features for hemocompatibility will prevent thrombosis and use of high-dose systemic anticoagulation with the high risk for brain bleeding. Importantly, ArtPlac allows family integrated care providing a therapy for the newborn in close connection to its family.  In summary, our visionary approach revolutioniz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Multiscale hierarchical imaging of the spiraled structure of narwhal tusk' (HI-Twist).

assistant: **Innovation**

Narwhals are mysterious animals that have fascinated humankind since ancient times. They are known for their unique spiralled tusks, which made people believe in the existence of unicorns for centuries. The up to 3 m long straight tusk displayed by males always has a left-hand spiral macrostructure, making it unique in the animal kingdom. Very little is known about these fascinating animals, and the reason, origin and biological structure of their tusk is a great question mark among marine biologists and bio-material scientists. In the proposed project, we will aim to reveal the hierarchical structure and biomineral characteristics of this unique biological material: their tusk. For that purpose, we will employ a combination of recently developed 3D X-ray imaging techniques in a hierarchical approach, studying their nano, micro and macrostructure with X-ray computed tomography, X-ray diffraction and X-ray small angle X-ray scattering. Novel imaging techniques using synchrotron radiation like tensor tomography will reveal the structural organization and anisotropy of the tusk building blocks, and diffraction computed tomography will provide very valuable information about the biomineral phase in the tusk and teeth. The multi-length scale approach explained in this project will be a pioneer in the field and we expect to establish a new methodology for a more complete structural characterization of biological and composite materials. All that will be implemented and developed in the 24 months of the project, which compiles 4 experiments in large-scale synchrotron facilities, data analysis strategies development and the establishment of a complete multiscale model of the narwhal tusk biological structure.


**Keywords:** X-ray imaging, Computed tomography, Tensor tomography
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Methane related iron reduction processes in sediments: Hidden couplings and their significance for carbon and iron cycles' in the context of a Horizon 2020 call.

assistant: **Objectives**

About one-third of annual methane (CH4) emissions to the atmosphere originate from natural, nonanthropogenicsources. However, if all the naturally produced methane actually did reach the atmosphere, itslevels would increase by an order of magnitude, dwarfing anthropogenic CO2 emissions. Fortunately, naturalscavengers of this methane near its production zone limit its release. One of these scavengers, iron (Fe) oxide,can become a major sink for methane when sulfate concentrations are low. Methane-iron couplings inestablished sediments, however, are poorly understood. Specifically, significant iron oxide reduction has beenobserved in many aquatic sediments at depths well below its expected redox zone, where methane is producedby methanogenesis, often accompanied by decreases in methane concentrations. These observations challengeour understandings of iron-methane couplings and microbial players in the deep methanogenic zone and theirimpacts on the carbon, iron and other cycles. I aim in the proposed research to elucidate the unexploredmechanisms of methane-related iron reduction (MERIR) in the methanogenic zone of establishedsedimentary profiles under various environmental conditions and their impact on global biogeochemicalcycles. I will resolve two striking yet unexplained phenomena: (1) the active involvement of aerobicmethanotrophs in iron-coupled anaerobic oxidation of methane (AOM), and (2) the unusual reactivityof iron minerals toward reduction that is accompanied by intensive authigenic magnetite precipitation, andthe effects of this mineralogy change on sedimentary magnetism. My expertise will enable me to achieve theobjectives of this interdisciplinary proposed work using novel approaches from different fields. The projectwill likely lead to breakthroughs in our