RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '3D geodynamic modelling of sedimentary basin and passive margin formation' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The work proposed here focuses on understanding the evolution and structural style of sedimentary basins and passive margins in 3 dimensions (3D) using state-of-the-art computational modelling techniques. Very few 3D models exist that follow the evolution of rifting to large deformation with sufficient resolution to resolve individual fault and shear zones. We will use state-of-the-art finite element techniques developed in collaboration with research partners in Canada and France to model the 3D evolution of sedimentary basin and passive margin formation. Insight into the 3D structural evolution of these systems is both a fundamental first order scientific problem but is also highly relevant for hydro-carbon exploration, as well as for understanding seismic hazard potential in these settings.The proposed project is part of the larger goal of establishing a Computational Geodynamics laboratory at the University of Bergen. The project will continue ongoing collaboration with research partners in Canada and France and will facilitate knowledge transfer from leading groups in the field (Geodynamics Groups at Dalhousie and Rennes University) to the host University. Significant expertise exists within the host University on observational aspects of sedimentary basins and passive margins, and on computational science and high performance computing, which both will be of direct benefit to the proposed project. Marine Sciences is one of the strategic areas of Bergen University.The Bergen Centre of Computational Science hosts one of the main supercomputer centres in Norway and associated expertise on high performance computing. The computational modelling techniques require use of substantial computer facilities. The proposed funds will be directed towards new computational infr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ecosystem-based strategies and innovations in water governance networks for adaptation to climate change in Latin American Landscapes' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

International debates on climate change highlight the need to foster adaptation planning in Latin America where significant impacts are expected. However, little progress has been made due to the difficulty of managing environmental dynamics characterized by deep uncertainties and potential tensions at various scales.EcoAdapt is built on the outcomes of two rounds on regional consultation with Latin American civil society organizations (CSO) and scientists. It aims at increasing the capacity of local communities, CSOs, policy-makers and scientists to engage in inter-disciplinary action-research to increase their collective capacity to adapt to climate change. The EcoAdapt CSOs stated that watershed services were the most critical with respect to possible tensions and social conflicts that may arise due to climate change. The EcoAdapt team considers that 1) adaptation to climate change is not something that can be done in isolation, and 2) ecosystem-based management is a robust basis for successful adaptation to climate change in Latin America. Therefore in the project concept, watershed ecosystem services (WES) are mainstreamed in an overall adaptation strategy by a variety of players involved in science-policy-civil society networks across-scales.EcoAdapt will be implemented in “model forest” landscapes in Argentina, Bolivia, and Chile. Knowledge sharing forms the backbone of the project and provides scientists and policy-makers with an in-depth insight into local knowledge and issues, which will frame the research to be done. Based on this common understanding EcoAdapt will assist communities in developing their WES-based adaptation strategy. This will be achieved by combining exploratory scenario analysis, participatory backcasting, and social validation via hybrid f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Electric bReaker Hammer transforming the mIning aNd cOnstruction industries to zero-emission.' (RHINO) targeting Horizon Europe.

assistant: **Abstract**

A fully electrical impact hammer (LEH) is proposed in this project in order to address the fundamental limitations from hydraulic breaker hammers (HBHs), as well as fostering opportunities in regard to electric transformation, digitalization (DigiLeka) and data based business in the construction and mining industries. This novel patented technological innovation is based on the tubularic linear permanent magnet motor. Compared to HBHs, LEH reduces CO2 emissions up to 100%, saves energy up to 60%, ends oil spills and excessive consumption of hydraulic oil, is fully adjustable, increases safety, lowers noise and tremor levels, provides significant life-cycle-cost savings (80000 EUR/hammer in 4 years), increases performance and precision, and allows adjusting striking sequence. This project will result in a totally new approach to hammering process in mining and construction providing a ground-breaking cost efficient, digitalized, connected, safe, environmental and user friendly solution.


**Keywords:** Sustainable mining,Electric Breaker Hammer,Construction,zero-emission
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Employment and health at 50+: a life history approach to european welfare state interventions'.

assistant: **Objectives**

Health and work are key determinants of our well-being. They are thus major objectives of the European welfare state, e.g. of the Lisbon agenda. Yet, health and employment vary tremendously across EU member states. The aim of this proposal is to shed light on the mechanisms through which welfare state interventions may be responsible for such differences and thus contribute to improved governance and policy design.We propose an innovative analysis of past and current welfare state interventions in Europe that has three powerful features: First, we will take a life history approach as we believe that the full effect of welfare state interventions can only be assessed over the entire life course and not by comparing concurrent policies and outcomes. Specifically, the proposed research will collect life history micro data to identify intervention points at which welfare state policies - such as education, income support programs, work place regulations, health care systems, old-age and disability pension systems - affect women and men at various points in their lives.Some interventions offset, others amplify each other, and they may have cumulative effects over the life course. Also, the timing of interventions is key in identifying their causal effects. Second, we use a multidisciplinary approach that explicitly accounts for the interactions between health, work conditions and employment. Analysing health or employment in isolation ignores the interactions between health care and labour market policies. These interactions are long-term but we believe that they are crucial in creating different health and employment outcomes.Finally, we base our analyses on an innovative combination of life history, cross-sectional micro and institutional macro data that takes account of g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dedicated integration and modelling of novel data and prior knowledge to enable systems biology' (DIAMONDS) targeting Sixth Framework.

assistant: **Abstract**

We will demonstrate the power of a Systems Biology approach to study the regulatory network structure of the most fundamental biological process in eukaryotes: the cell cycle. An integrative approach will be applied to build a basic model of the cell cycle, in four different species including S. cervisiae (budding yeast), S. pombe (fission yeast), A. thaliana (weed, model plant) and human cells. To do this,a Consortium is assembled of leaders in the fields of cell cycle biology, functional genomics technologies, database design and development, data analysis and integration technology, in addition to modelling and simulation approaches. The project combines a number of complementary data sets, toward an advanced mining and modelling environment designed to assist the biologist in building and amending hypotheses, and to help the investigator when designing new experiments to challenge these hypotheses. By doing this simultaneously in widely different organisms we will ensure that the tools are generally applicable across species. By bringing together in the design phase biologists, bioinfomaticians, biomathematicians and (commercial) software developers we will ensure that a user-friendly, intuitive data analysis environment is created.The main data streams generated de novo within the project concern transcript profiling and proteomics data (Y2H and TAP).These data will be complemented with information extracted through comparative genomics, and prior knowledge coming from literature mining (text mining toots). The project will bring together a number of existing technologies to build a knowledge warehouse in a relational database designed to contain cell cycle regulatory network information, accessible through an intuitive user platform (GUI) with embedded modelling t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Study of CP Violation and Flavour Structure as a Probe of Physics beyond the Standard Model' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

CP violation and flavour changing phenomena provide an unique window to physics beyond the Standard Model. Our main goal is to extract information about new particles, for instance the super-partners of quarks (squarks) predicted by the super-symmetric ( SUSY) extension of the Standard Model (SM), by fully taking advantage of the data from B meson experiments (Babar, Belle, LHCb). Being the world highest luminosity machines, these experiments are able to observe extremely rare B decays, in which we would search for manifestations of CP and flavour violations not predicted by SM.In SUSY models, extra sources of CP and flavour violation are introduced through SUSY breaking, which explains the large masses of SUSY particles. Our target is to strictly constrain the flavour structure of the down-type squark mass matrix by using data from B meson experiments. We will proceed our project providing high precision theoretical predictions for B decays, which is most important since new physics effects can be extremely small.The largest difficulties for this purpose come from strong interaction effects, requiring various techniques in quantum chromo-dynamics (QCD). We will carefully incorporate their latest developments, such as QCD factorisation, perturbative QCD method, QCD sum-rule and large Nc expansion (Nc being the number of colours). Actually, CP violation and flavour structure are also intensively studied in the neutrino sector, triggered by the confirmation of massive neutrinos by SuperKamiokande and SNO experiments.It has recently been shown that the observed third and second-generation neutrino oscillations can have an impact on the same generation quarks (bottom to strange) transition, in the framework of SUSY Grand Unified Theory (GUT). We are therefore interested in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The initial stream of a urine void.' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The ability to easily obtain appropriate and reliable biological samples is critical to advancing life sciences and public/personal health. Having a sample that is non-invasive and can be self-collected at home has major acceptance and implementation advantages. Our team has already demonstrated that first-void urine (FVU) samples can replace clinician-collected cervical samples in Human Papillomavirus (HPV) based cervical cancer screening. Using the initial or first-void urine stream is crucial here. Indeed, the outer layers of the epithelium of the genital tract exfoliate and together with the genital mucus form the utero-cervico-vaginal secretions. This discharge accumulates between the labia minora, around the urethral opening, and is washed away with the FVU upon initiation of urination. The URISAMP project is making good progress to demonstrate that, using HPV infection and vaccination as a model, FVU is indeed an ideal genital tract liquid biopsy to monitor both disease and immune response of women at the site of infection. Importantly, diagnostic, screening, and monitoring applications via FVU samples are growing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Establishment of a novel CML model using Multi-Hit technology' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The chronic phase of chronic myeloid leukaemia (CML) is characterized by the expression of the chimeric BCR-ABL gene, extended survival, and profligate growth of maturing granulocyte stemline. It provided the rationale for producing first imatinib and then a series of small molecules designed to inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein, all of which can induce complete cytogenetic remissions in the majority of patients with CML in the chronic phase (CP). Selective inhibition of the BCR-ABL tyrosine kinase by imatinib is a promising new therapeutic strategy in patients with CML. Despite significant haematologic and cytogenetic responses, resistance occurs, particularly in patients with advanced disease, accelerated phase and blast crisis. The mechanism by which the transition from chronic to accelerated phase (AP) or blast crisis (BC) occurs remains poorly understood. The AP and BC phase of CML are usually manifested by additionally acquired oncogene aberrations, resistance to therapy, advancing anaplasia, progressive organomegaly, and increased blast count. Abnormal expression of some proto-oncogenes may accompany or even precede AP or BC of CML. Therefore, it is a critical issue to identify the molecule(s) which is (are) involved in the transition from CP to BC. To better understand such a complex clinical course of human CML, the generation of animal models that closely resemble the situation in people is indispensable. Our objective is to reveal the in vivo pathogenesis of CML with advanced phase using a novel mouse model. Moreover, an indispensable molecule for CML transition can be expected to be found in our study, which might be exploited for both prognostic indicators as well as new targets for therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nodding Syndrome:  a trans-disciplinary approach to identify the cause and decrease the incidence of river epilepsy', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Nodding syndrome (NS) is a neurological, incurable syndrome, currently affecting mainly children between 5 and 15 years of age in South Sudan, Uganda and Tanzania. Since 1950, when NS was first described, its cause has remained a mystery. NS is characterized by head-nodding (an atonic form of epilepsy), often followed by clonic - tonic seizures, developmental retardation and faltering growth. In the affected regions, NS is a major public health problem associated with severe socio-economic consequences. After exploratory missions to South Sudan, Uganda and the Democratic Republic of the Congo (DRC), we gathered epidemiological evidence that supports the hypothesis that NS is a disease caused by a pathogen transmitted by blackflies, the  vectors that transmit the parasitic worm that causes onchocerciasis.  This pathogen could be an unknown neurotropic virus or another pathogen that is transmitted either independently or as a symbiont of the worm. We postulate that this pathogen is able to cause typical NS, but also other forms of epidemic epilepsy. We hypothesise that the same disease is also endemic in other onchocerciasis hyper-endemic regions e.g. in the Mbam valley, Cameroon and the Orientale Province, DRC (where it is referred to as “river epilepsy”).  In this project we aim to investigate our hypotheses in South Sudan, Uganda, Tanzania, Cameroon and the DRC with a trans-disciplinary approach including clinical-epidemiological, post-mortem, eco-entomological, and metagenomic studies. We will study the effect of vector control methods and ivermectin distribution on the incidence of river epilepsy. So far a multi-country study on NS was never done and nearly all previous studies were cross-sectional, carried out during short country visits. With this long term researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'GIMM-CARE: BOOSTING CLINICAL RESEARCH FOR THE BENEFIT OF SOCIETY' (GIMM-CARE).

assistant: **Innovation**

GIMM-CARE will deliver a pioneering Centre of Excellence (CoE) in human-centred clinical and translational research in Portugal by teaming up Gulbenkian Institute for Molecular Medicine (GIMM) with Vall d'Hebron Barcelona Hospital Institute of Research (VHIR). Having VHIR as a role model and strategic partner will create the framework and actions to have the best health care and research on a single campus – the Lisbon Academic Medical Centre (CAML) - catalysing a virtuous continuum across all stages of biomedical research, from bench to bedside and back again.GIMM-CARE will develop and promote excellence in clinical and translational research, profoundly transforming how clinical and translational research is conceptualized, planned and implemented to deliver effective solutions to the most pressing health needs. The CoE will have at its core a mission-driven, human-centred, data-driven research and innovation (R&I) model as a new way to engage all stakeholders – citizens, patients, healthcare professionals, scientists, entrepreneurs, industry, health authorities and government – in interdisciplinary, cross-sectoral collaborations to solve health challenges. An articulated set of coordination and support actions will be driven by disease-specific missions, place people (citizens and patients) at the core of the R&I process, and leverage the power of new digital technologies and data to accelerate the path of R&I in broad collaborative efforts across the healthcare value chain. The broad collaborative efforts will follow the quadruple helix approach, use open innovation and open science methods to develop and enhance R&I capacities and projects to facilitate a rapid uptake of advanced technologies and solutions by healthcare systems at national and international levels.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'IPM-4-Citrus, Citrus desease Integrated Pest Management: from Research to Market' to be submitted under Horizon 2020.

assistant: **Abstract**

IPM-4-Citrus aims to strengthen collaborations between academic and non-academic partners based in 3 European Member States (FR, GER, IT), 2 Associated Countries (Turkey and Tunisia) and 1 Third Country (Lebanon), in order to develop a new bio-pesticide active against citrus pests and scale it up from lab to market. The project’s research and innovation activities are based on a multidisciplinary approach, which aims at understanding and sensitising stakeholders about the health risk factors related to citrus pests and their treatment by chemical pesticides and developing an alternative Integrated Pest Management (IPM) approach based on biological control. Bacillus thuringiensis (Bt) based bio pesticides occupy almost 97% of the world’s bio pesticide market and their use was estimated to exceed 30,000 tons. Despite this widespread use, the originality of Citrus-IPM is to focus on 2 promising, newly identified strains (Bt kurstaki BLB1 and LIP), which were shown to be more efficient than the commercial (Bt kurstaki HD1). In conjunction with validation through field tests, the project will pave the way for future commercial exploitation of a new biopesticide product by drawing up a feasibility study for future spin-off activities and/or new production lines in partner SMEs. Staff secondments and inter-sector and international mobilities between complementary partners will represent a unique opportunity to optimise bioproduction processes and obtain high added-value bioproducts, while building up the partners’ skills and reinforcing the training of early-stage researchers through knowledge sharing and networking. Inter-sectors mobility will bring SMEs and researchers to work conjointly on conditioning procedures for field tests, impact evaluation and product maturation/exp