RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A Comprehensive Supramolecular Approach for an RNA vaccine for Influenza A (H1N1)', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

*The development of vaccines is key for disease prevention, and is a major focus globally in the healthcare sector. Seasonal influenza is an acute respiratory infection caused by influenza viruses which circulate in all parts of the world. Seasonally, it remains a persistent health threat and has been declared an epidemic in some states. Typical vaccines have been less effective against rapidly evolving pathogens such as influenza. A new class of vaccines based on nucleic acids, namely RNA, have recently been developed and show immense promise due to their robust nature, short manufacturing times and enhanced efficacy. Here we propose an RNA delivery system based on a supramolecular assembly approach for the vaccination of influenza A H1N1 strain. Specifically, a π-amphiphile will be used as the platform molecule for covalent RNA conjugation and delivery. A messenger RNA (mRNA) targeting the hemagglutinin (HA) gene from a model influenza virus strain will be employed as the therapeutic (H1N1/PR8-HA). The central π-amphiphile moiety will befunctionalized with the mRNA strand via a redox responsive disulfide bond, and hydrophilic oligo-oxy aryl groups connected via a hydrogen bonding unit to promote self-assembly. Steric stabilization will be afforded to the surface decorated mRNA to protect from enzymatic hydrolysis in the complex biological environments, through co-assembly with an analogue π-amphiphile which has been alternatively decorated with poly(ethylene glycol) (PEG) chains. Efficient intracellular transport of the delivery vehicle to achieveoptimum mRNA transfection will be achieved through the incorporation of a TAT-peptide on the PEG chain end. The therapeutic efficacy of the nanoassembly will be evaluated through transfection efficacy in macrophage cell lines
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Arctic Research Icebreaker Consortium: A strategy for meeting the needs for marine-based research in the Arctic' to be submitted under Horizon 2020.

assistant: **Abstract**

The recent changes of the Arctic and the increased economic activity in the region have triggered a demand for accurate sea-ice and weather predictions, for information on the status of the Arctic Ocean, and for complex predictions of future scenarios. To address these issues of particular environmental and societal concern and to develop policy recommendations for a sustainable usage of the Arctic Ocean and its resources, the Arctic science community needs world-class research icebreakers (RIs) to access the ice-covered Arctic Ocean. The current shortage of availability of RIs and a not optimally coordinated polar research fleet impedes Europe’s capacity to investigate this region. There is thus an urgent need for providing European researchers with better RI capacities for the Arctic. ARICE aims at reaching this goal with the existing polar fleet by:1) NetworkingARICE will develop strategies to ensure the optimal use of the existing polar research vessels at a European and international level, working towards an International Arctic Research Icebreaker Consortium which will share and jointly fund operational ship time on the available RIs.2) Trans-national access (TNA)ARICE will provide TNA to six key European and international RIs for European scientists, based on scientific excellence of submitted proposals:- PRV Polarstern, Germany- IB Oden, Sweden- RV Kronprins Haakon, Norway (under construction, to be operative in 2017)- RRS Sir David Attenborough, United Kingdom (under construction, to be operative in 2018)- CCGS Amundsen, Canada- RV Sikuliaq, United States of America3) Joint research activitiesARICE will improve the RIs’ services by partnering with maritime industry on a “ships and platforms of opportunity” programme and by exploring into new technologies that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Models and observations to test climate feedbacks' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The project will assess the ability of state-of-the-art European models used to project future climates to reproduce a climate different from today through comparisons with benchmark palaeo environrnental datasets. We will analyse both mean climate, internal to multi-decadal climate viability, and the relationship between them. The European models include dynamic representations of the atmosphere, ocean, sea-ice and land-surface, and interactions among these components. The project will use different configurations of the coupled models to study feedbacks between ocean circulation, vegetation and the atmosphere. We focus on 6000 years before present (6 ka) and 21 ka, which represent different states of the climate system and the ocean circulation. In addition to using global syntheses of palaoenvironmental data to evaluate the simulated mean climate, we will use high-resolution terrestrial and marine records to evaluate the simulated changes in high-frequency variability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An assessment of VOC and ozone fluxes in crop plantations from the leaf to the ecosystem level. Relationships with the plant physiology and implications for air quality' (CITROVOC) targeting Seventh Framework.

assistant: **Abstract**

Citrus plants are largely grown and economically valuable crops in densely inhabited and polluted Mediterranean areas. Citrus species produce and emit VOC (Volatile Organic Compounds) which enter gas-phase reactions leading to formation of dangerous levels of atmospheric ozone especially in the presence of anthropogenic pollutants. On the other hand, biogenic VOC destroy ozone at leaf level enhancing plant protection against the pollutant. CITROVOC is keyed at understanding the dual role of VOC emitted by Citrus in regulating ozone formation and deposition in Mediterranean areas that are plagued by high ozone episodes. A three-year study, at cellular, whole plant, and ecosystem level, is proposed to understand basic mechanisms leading to ozone interactions with BVOC, to quantify VOC-dependent ozone removal, and to scale up results at community level. Temporal and spatial variations of stomatal ozone uptake, and VOC-induced ozone destruction or ozone formation in the low troposphere will be assessed. The ozone-VOC chemistry will be studied as functions of genetics, phenology, environment, and agricultural practices. The outstanding expertise of the host Institutions, spanning from plant biology to atmospheric chemistry, will allow the applicant to consolidate the strong, interdisciplinary background needed to undertake complex and novel studies about biosphere-atmosphere interactions and their impact on a changing environment. CITROVOC results will usefully complement or upgrade VOC and pollution emission models, contributing to practices and policies for the improvement of air quality and plant protection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'FASTAP Transformer for Wind Turbines' in the context of a Horizon 2020 call.

assistant: **Objectives**

The energy market in general, and the wind energy market in particular, are experiencing constant decrease of prices, together with harsher and harsher grid conditions. In order to comply with worldwide environmental policies, revolutionary solutions, such as FASTAP, need to reach the market as soon as possible. The FASTAP project aims at scaling from TRL6 to TRL8 the wind turbine application of a very fast on-load tap changer transformer technology. This solution uses thyristors specially connected to multi-tap transformer windings to provide On-Load Tap Changer capability to a standard wind turbine (WTG) transformer. This technology allows to choose the optimum voltage at which the WTG operates in, not only in steady-state conditions but also for dynamic and transient events. This technology will increase WTGs' electric capabilities in weak grid conditions, enlarge WTGs' Low and High Voltage Ride Through capabilities and allow reducing electrical components oversizing. As an overall, the FASTAP will be able to reduce wind's Leverage Cost of Energy up to 5.5% and will be able to connect to worldwide grids an additional 71.64GW wind capacity. The consortium partners have been working together for the last three years to bring the technology up to TRL6. They cover the whole value chain, which guarantees that the product will reach the market 33 months after the project kicks-off: - INF, the market leader in bipolar high-performance semiconductors, brings the technical know-how and commercial capacity for thyristors-based semiconductors. -SGB,  number one medium-sized manufacturer of transformers in Europe, brings the technical know-how and commercial capacity for transformers. -SG, WTG market leader, will be the integrator and validator of the FASTAP product into <5MW an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'INcrease Corporate political responsibility and Accountability (INCA)' (INCA).

assistant: **Innovation**

INCA project investigates the impact that so-called digital platforms have on European democracies and institutions. Indeed, while promoting economic growth and labour transformations, these platforms pose challenges to policymakers and citizens in relation to people’ participation in decision-making processes, wealth inequalities and erosion of trust into public institutions. In particular, so-called GAFAM (Google, Amazon, Facebook, Apple and Microsoft) are becoming more and more infrastructures for opinion-making, labour organization and political debate. Their increasing power in shaping and influencing such issues through lobbying, industrial relations and cultural impact opened up a wide debate on the way to deal with these transformations. While European societies grew up based on liberal democracies and institutions with their capacity to sustain a coordinated market economy, today their role seems to be reduced because of the difficulties to regulate platforms’ corporate power that spread through politics, economy and culture.INCA aims to•define forms to sustain trust in institutions and new models of governance capable to combine the growth of platforms with social inclusion and citizens participation in decision making processes;•stimulate alternative business models and industrial relations so to make GAFAM and platforms accountable to social fairness while preserving their innovation;•to clarify the way GAFAM influence European citizens opinion conditioning democratic processes.Exploring the socio-historical roots behind platforms growth and the erosion of a coordinated market economy, collecting solid data on GAFAM lobbying, industrial relations and opinion-making, and producing participatory actions for the empowerment of democratic processes and citizens’
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Demise of the Atlantic Grey Whale'.

assistant: **Innovation**

The grey whale (Eschrichtius robustus) is a baleen whale species currently restricted to the North Pacific. Palaeontological and archaeological evidence has, however, revealed that the species was once also present in the North Atlantic, having migrated from the North Pacific by 50,000 cal BP. These Atlantic Ocean populations were then extirpated in historical times, perhaps around the 12th century AD in the eastern Atlantic and by the 17th/18th century AD in the western Atlantic. In the past decade several individuals from the North Pacific population have been sighted in the Atlantic, suggesting the species might return to European waters in the future. If the species returns, strong conservation actions need to be implemented implemented in order to safeguard its recolonization of European waters. Modern marine management strategies are often reliant on data which lacks the long-term perspective that archaeology can contribute. Informing these modern approaches to protecting the grey whale can be achieved through investigating baseline data in prehistoric and historic periods. It is the aim of this project to apply an interdisciplinary approach, combining archaeological/historical methods, traditional zooarchaeology, ZooMS analysis, stable isotope analysis, and aDNA analysis on a step-by-step basis in order to identify past species selection by whalers, the past space/time distribution of the grey whale in European waters, reconstruct the past migration route(s) and feeding ecology of grey whales in European waters, and reconstruct grey whale demographic history and genetic diversity. This will reveal what factors led to the extirpation of the grey whale from the eastern Atlantic and whether anthropogenic pressure played a role. Besides the archaeological and histori
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Identification and characterization of the factors involved in CYP3A4 inter-individual variability' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

The molecular basis that makes a therapeutic drug become toxic has an enormous clinical relevance: it has been estimated that the fatal adverse drug reactions are between the 4th and 6th leading cause of death in developed countries. In addition, the lack of therapeutic effect of a drug by a deficient formation of the active metabolite or by its fast elimination can also lead to death.The cytochrome P450s (CYPs) are the most relevant enzymes catalysing the biotransformation of drugs, and many of the fatal adverse drug reactions, as well as a lack of therapeutic effect of drugs, are due to an abnormal CYP activity. In the human liver the most important enzyme catalysing the biotransformation of drugs is the cytochrome P450 3A4 (CYP3A4).This CYP is involved in the metabolism of 50% of currently used therapeutic drugs. As a consequence, variations in CYP3A4 activity have a major impact on pharmacokinetics and metabolic fate of drugs, drug-drug interactions and toxicology. In the population there are great differences in CYP3A4 activity and the result is a great inter-individual variability in the susceptibility to toxics, optimal drug doses and adverse reactions.Nowadays, CYP3A4 activity variability is unpredictable, since the molecular mechanisms responsible for it are still unknown. Several studies have shown that this variability is genetically determined, ruling out environmental factors. In this project we intend to identify the critical mechanisms regulating CYP3A4 expression and then investigate whether these mechanisms are susceptible of inter-individual variability.In a first step, the obtained information (genetic markers) will be used in connection to cardiovascular diseases, trying to find an association between them and the pharmacological effect obtained with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nanowires for single photon detection and spin memory devices' under Seventh Framework.

assistant: **Concept**

The ultimate limit in the miniaturization of electronics and photonics is at the nanometer scale. Here the signal level can be controlled at the fundamental level of a single electron and a single photon. These limits are actively being pursued for scientific interest with possible applications in the area of quantum information processing and communication. We propose novel devices aimed at single photon detection and single spin memory using nanowires. The basic building block is a III-V quantum dot defined in a Si nanowire. We will develop the following technology: (1) growth of complex semiconductor nanowire, (2) quantum state storage and transfer onto a photon state for the memory device, and (3) single photon detection and electron multiplication for single photon detection. The nanowires will be grown by the vapor-liquid-solid mechanism. The structures and devices obtained after growth and each nanofabrication steps will be thoroughly characterized and the final test devices performances will be evaluated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'NGI FORWARD' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

NGI Forward brings together a consortium of leading organisations in the NGI and the internet space more broadly to help further the Next Generation Internet as the key European entity and space for radical new thinking on the future internet, by both conducting and bringing together the latest thinking and cutting edge research, and reaching a critical mass of Europeans through our ambitious engagement strategies.Our main aim is to articulate an ambitious vision for what we want the Next Generation Internet to be, involving diverse voices in the process. We set out a clear set of next steps towards this vision through the development of technology, value and policy roadmaps, and build a network of the key European stakeholders we need to empower in order to achieve these goals. Employing cutting-edge data methodologies we continuously identify newly emerging technologies, social issues and communities likely to play a key role in the shaping of the future internet. Understanding these emerging dynamics allows us, and by extension the European Commission, to become involved in shaping their development early on, embedding key values for the Next Generation Internet in the process. We build a strong and vibrant community of key stakeholders (innovators, researchers, policymakers and the general public) surrounding these topics to drive forward the NGI, involving both leading internet thinkers and well-established innovators, as well as young talent and otherwise untapped talent pools. Through leading edge qualitative and quantitative research (such deep learning, ethnography and futures methodologies), we map out the main research and policy needs and opportunities surrounding these topics, empowering our stakeholders group to take action.


**Keywords:** Human-centric,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European ocean energy association' to be submitted under Sixth Framework.

assistant: **Abstract**

The newly established European Ocean Energy Association (EU-OEA) is seeking financial support from the EC for activities aimed to complement other instruments in the implementation of the Framework Programme. This proposal for the Specific Support Actions intended to support EU-wide dissemination of information and activities relative to the development of Ocean Energy to become a significant contributor to renewable energy generation in Europe. The aim of the proposed activities is to contribute and actively support implementation of activities of the Framework Programme, analysis and dissemination of results, and definition of future activities, with a view to enable the Community to achieve its RTD strategic objectives.