RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DNA Excitonics' in the context of a Seventh Framework call.

assistant: **Objectives**

The bases that make up the DNA double helix absorb ultraviolet light. There is much debate about the way nature avoids radiation damage to DNA. Furthermore, the unique characteristic of an organized sequence of closely spaced base pairs, exploited in living organisms, can be used to tune the electronic structure for photo physical functionality in future applications. To understand the special properties of the DNA double helix that make it possible to avoid radiation damage, and their use in applications, new state of the art laser experiments are in progress in the host group. However, although these experiments give a wealth of information about the properties of DNA, due to their highly complex nature their interpretation is far from straightforward. New theory is necessary to interpret these measurements. This project aims at the establishment of a unique collaboration between theory and experiment to understand how the closely spaced DNA bases control its optical properties, and how manipulation of the base sequence can be exploited for applications. In particular, the transport of energy through the helix after absorption of light and the possibility of charge separation will be clarified. To this end, a new theory will be developed in close collaboration with experimental work. The theory will find direct application to DNA, but will also be applicable to related systems such as conjugated polymers and biological light-harvesting complexes, where both energy transport and charge separation are directly relevant for the function.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Investigation of the mechanism of action of antimalarial agents, by means of computational methods. Bases for the rational design of new antimalarial drugs'.

assistant: **Innovation**

Malaria is one of the three major communicable disease linked to poverty identified in Priority Thematic Area 1.1.1.ii.c. It is estimated to cause up to 500 million clinical cases and over one million deaths each year, with the African child the parasite's main target. The host organization will participate to the work package number WP 4.1.2.4, of the Integrated Project ANTIMAL, supported by EEC under the 6th FP. Chemotherapy has been and will remain the central strategy for malaria treatment. Currently the emergence of resistance, particularly to the first and second line treatments (chloroquine and Fansidar respectively), coupled with the dearth of new anti-malarial drugs under development, has compromised the ability to deal with this major human pathogen. Thus there is an urgent need for new drugs. The objective of this proposal is to approach antimalarial drug design by means of an innovative computational protocol which combines ab-initio calculations on metal-organic complexes with a classical drug design approach. Albeit marketed antimalarials are very old drugs, their mechanism of action is still being debated. Nevertheless it is current opinion that, at the basis of their activity and/or toxicity, despite wide structural differences, there is the common capability to interact with redox processes leading to surviving parasite, through a metal-mediated radical formation. Among computational methods, ab initio calculations represent the more suitable tool to evaluate radical formation and stability. Therefore, in order to develop effective antimalarial drugs, the host organization needs to implement the skills in rational drug design, by the acquisition of expertise in the quantum chemistry field. Moreover, the transfer of knowledge will contribute to the stren
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'EVA - patient ventilation beyond limits' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

EVA - Expiratory Ventilation Assistance – , or expiration by suction, is an innovative method to mechanically ventilate patients and is a key step in ventilation towards less-invasive, tailored and improved patient care as it enables:1. full ventilation through a thin catheter instead of a thick tube2. low and – if needed – negative pressures in the lungs promoting blood circulation3. controlling the expiration, reducing sheer stress, which may prevent lung injury and improve patient outcome.The EVA technology has already been on the market for some years in its most basic form: the manual, disposable emergency ventilator Ventrain®. Since market launch in 2011, Ventrain® is now being sold by 16 distributors in over 20 countries. Ventinova’s flagship is the “EVA device”: a fully automated ventilator based on EVA technology meeting the emerging needs of less invasive, tailored and improved patient care. First is focused on the large markets of elective surgical procedures and emergency care (€ 400 M, globally) and in 2nd generation on ICU-ventilation (€ 500 M, globally), before becoming ‘standard care’ (€ 4.6 billion, globally). The device, currently at TRL6, is still in development and CE marking is expected in Q3 2016. Next to marketing activities, such as organizing workshops and training sessions, and careful selection and support of distributors, penetration of the conservative medical market should be ensured by demonstration of better and tailored patient care using EVA ventilation in pre-clinical studies and controlled clinical trials. These are to be designed and executed in close collaboration with Key Opinion Leaders of established and world leading academic medical centers. The described technology and products are protected by 5 patent families and design and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Acquisition processes in maximally diverse languages: Min(d)ing the ambient language'.

assistant: **Innovation**

Children learn any language that they grow up with, adapting to any of the ca. 7000 languages of the world, no matter how divergent or complex their structures are. What cognitive processes make this extreme flexibility possible? This is one of the most burning questions in cognitive science and the ACQDIV project aims at answering it by testing and refining the following leading hypothesis: Language acquisition is flexible and adaptive to any kind of language because it relies on a small set of universal cognitive processes that variably target different structures at different times during acquisition in every language. The project aims at establishing the precise set of processes and at determining the conditions of variation across maximally diverse languages. This project focuses on three processes: (i) distributional learning, (ii) generalization-based learning and (iii) interaction-based learning. To investigate these processes I will work with a sample of five clusters of languages including longitudinal data of two languages each. The clusters were determined by a clustering algorithm seeking the structurally most divergent languages in a typological database. The languages are: Cluster 1: Slavey and Cree, Cluster 2: Indonesian and Yucatec, Cluster 3: Inuktitut and Chintang, Cluster 4: Sesotho and Russian, Cluster 5: Japanese and Turkish. For all languages, corpora are available, except for Slavey where fieldwork is planned. The leading hypothesis will be tested against the acquisition of aspect and negation in each language of the sample and also against the two structures in each language that are most salient and challenging in them (e. g. complex morphology in Chintang). The acquisition processes also depend on statistical patterns in the input children rec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biodiversity assessment and conservation science' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

This programme will allow Fellows great flexibility to obtain a blend of skills & experience that best matches their own career aspirations, and that builds on their own past experience. Fellows will enjoy an inter-disciplinary & multi-national work environment, where they will gain experience of a wide range of active research programmes. Participating Fellows will benefit from the three principal innovative aspects to the CBC: 1) Juxtaposition of state-of-the-art expertise in theoretical modelling, laboratory and field experimentation, and long-term observation. 2) Integration of biological, geographical and geological perspectives to provide the appropriate disciplinary expertise for scaling up biological work in space and time. 3) Global reach of field programmes, with active biodiversity research on seven continents.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Entailing Perpetuity: Family, Power, Identity. The Social Agency of a Corporate Body (Southern Europe, 14th-17th Centuries)' (VINCULUM), addressing dissemination and exploitation.

assistant: **Impact**

Few legal phenomena have been so relevant to premodern southern Europe societies as entails, a specific strategy that evolved to protect family inheritances, thus enabling the reproduction of elite social status. The VINCULUM project aims to explain how entailment became possible, how it functioned, and why it lasted for so many centuries. The project rests on the innovative theoretical claim that entails, as corporate bodies, functioned as a key social agent, created and acting within societies for which non-personal legal subjects were normal. Building on the Portuguese-Iberian case, and on the extensive research already carried out by me and my team, I propose to study 'entailment' as a diverse but pivotal practice, one embedded in law, aristocratic discourse, and kinship-based organization, and to carry out comprehensive analysis that explores this global nature.  The research approach systematically breaks with traditional research frontiers: cases will extend from the 14th to 17th century in both continental and Atlantic spaces, and include both comparative perspectives and the study of later social reconfigurations.VINCULUM will be anchored in extended research in public archives and on unprecedented access to extensive private family archives, which have been opened to research by the ARQFAM program I have led since 2008. Data collection will allow for the construction of a large database, gathering all documents relating to each entail, under a theoretical model that seeks to reconstruct past information systems, thus testing a novel methodology developed in my previous research. The database that will gather c.7000 thousand entails, enabling systematic inquiries organized around the new conceptual definitions proposed by the project. The research will be stron
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel approaches to determining the function of tissue-specific regulatory T cells' (Tissue-Tregs) under Horizon 2020.

assistant: **Objectives**

Regulatory T cells (Tregs) are formed through the expression of the transcription factor Foxp3 in T cells, resulting in the rewiring of the cell function into an immunosuppressive phenotype. Recently, it has been proposed that Tregs also have additional tissue-specific physiological roles when resident in different tissues. For example, tissue-specific Tregs residing in the muscle and adipose tissue possess immunological and non-immunological functions in these tissues, distinct from the generic Tregs in circulation. Currently, research into tissue-specific functions of Tregs, or any other migratory cell type, is limited by the available research tools. A vital part of immunological studies is cell depletion, yet a major limitation of all available methods is that they deplete target cells across the entire organism. This makes it extremely difficult to ascertain the function of tissue-resident Tregs, as systemic deletion results in severe autoimmunity, confounding the study of tissue-specific subsets. In order to assess these tissue-resident subsets new research tools are required to deplete the target cells in a specific anatomical region while leaving the same cell type unaffected in other organs. This project proposes to generate new synthetic biology tools for depleting tissue-resident cells and then to apply these tools to the study of tissue-resident Tregs in the brain, lung, liver, kidney and pancreas, thus creating a comprehensive atlas of tissue-specific functions. These studies will be extended by systematic molecular, cellular and kinetic analysis using existing innovative methods established in the laboratory. Finally, our tissue-specific deletion system will have a profound impact on immunology beyond the direct scope of the project, as the tools will be d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'European Training and Research Program in Translational Vision Science to ensure Optimal support of Visually Impaired Individuals through Tests and Tools of Functional Vision'.

assistant: **Objectives**

OptiVisT’s key mission is to enhance the societal participation of individuals with vision impairment through innovative and inclusive care. To achieve this, we need new knowledge as well as new, innovative tests to assess functional visual abilities, and develop tools to train and augment them. We thus need Translational Vision Scientists, with expertise in vision science, technology and healthcare. Such scientists are in great demand, but scarce, because there is as yet no specialist training program. OptiVisT arose from the realization that we can only meet this need by joining forces across Europe and integrating our pioneering efforts. We will train 15 early stage researchers (ESRs) to become the pivotal next generation of specialists in Translational Vision Science, ready to take on leading positions to the benefit of healthcare, industry and science. Our consortium offers all the essential components to nurture this new generation of cutting-edge scientists: they will learn how to quantify the visual demands of activities of daily living and to use their new insights to design objective, effective and easy-to-use tests and tools of functional vision. These must also be of an inclusive nature so that also vulnerable people with vision impairment can use them. Experts in the application, evaluation and valorization of solutions will ensure that our ESRs also know how to make their new tests and tools succeed in the real world. Thus, we will equip the ESRs with a unique portfolio of skills and competences, well-balanced for both academic and non-academic careers. Their skills are urgently needed to remove the roadblocks that presently limit progress in the translational vision field. Our innovative research program will guarantee that ESRs can make a real difference
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Fussy logics based control system for the overall production process of ceramic parts' (FLOCO-CERAMIC) targeting Fourth Framework.

assistant: **Abstract**

The proposed research project will be a CRAFT project, directed to the Ceremic bricks and tiles sector. The industrial objective of the proposed research is: - to increase the flexibility and adapatation capacity of the production process for the production of different product types; - to obtain an optimal reduction of energy consumption for production batches; - to enhance production capacity maintaining high product quality; at Manufacturers of Ceramic Tiles and Bricks. The project will develop, install and test at the site of the ceramic brick and tiles manufacturers, a prototype Control System based on fussy logics, controlling the whole ceramic parts production process, from the preparation of the clay, the drying and the baking (Kiln). The RTD goal is to develop a control system of the overall production process of ceramic bricks and tiles: - based on fussy logics, which aliows for more flexibility and more precise adaptation and modification of parameters; - measuring and integrating the values of the variables of the three different production operations; - using the parameters of the product for regulation of temperature, humidity and pressure; The research and development will consist of three main steps: 1 .The development of tools to determine the air parameters/curves necessary to obtain the given (fixed) product parameters/curves 2 The development of the Fussy Logics based control systems for each of the sub-systems 3 Development of the Global (overall) Control system The prime proposer of the project is BERALMAR a Spanish SME manufacturing production equipment for ceramic bricks and tiles manufacturers. Furthermore the project consortium will consist of 4 to 6 ceramic brick andd tiles manufacturers and 2 RTD performers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Discovering microbiome-based disease risk factors' (BiomeRiskFactors).

assistant: **Concept**

Identifying risk factors for diseases that can be prevented or delayed by early intervention is of major importance, and numerous genetic, lifestyle, anthropometric and clinical risk factors were found for many different diseases. Another source of potentially pertinent disease risk factors is the human microbiome - the collective genome of trillions of bacteria, viruses, fungi, and parasites that reside in the human gut. However, very few microbiome disease markers were found to date.Here, we aim to develop risk prediction tools based on the human microbiome that predict the likelihood of an individual to develop a particular condition or disease within 5-10 years. We will use a cohort of >2200 individuals that my group previously assembled, for whom we have clinical profiles, gut microbiome data, and banked blood and stool samples. We will invite people 5-10 years after their initial recruitment time, profile disease status and blood markers, and develop algorithms for predicting 5-10 year onset of Type 2 diabetes, cardiovascular disease, and obesity, using microbiome data from recruitment time.To increase the likelihood of finding microbiome markers predictive of disease onset, we will develop novel experimental and computational methods for in-depth characterization of microbial gene function, the metabolites produced by the microbiome, the underexplored fungal microbiome members, and the interactions between the gut microbiota and the host adaptive immune system. We will then apply these methods to >2200 banked samples from cohort recruitment time and use the resulting data in devising our microbiome-based risk prediction tools. In themselves, these novel assays and their application to >2200 samples should greatly advance the microbiome field.If successful, our pr