RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Hopes and Futures of Academia: Reimagining Bacon's New Atlantis' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

ATLANTIS tackles the multifaceted challenges facing academia today by focusing on alternatives articulated within or at the boundaries of higher education. These challenges are not only practical, but also deeply theoretical and engage fundamental epistemological and ontological discussions about the intertwinedness of science and society, and the knowledge this relation generates. Using Francis Bacon’s New Atlantis (1626) as a reference point, this project’s ambition is to co-create different narratives, infrastructures and frameworks that amend the consequences of the technocratic imaginaries of knowledge and progress crystallised in this story. Following the lead of researchers that have taken people’s hopes and visions as objects of analysis and entry points into broader societal concerns, ATLANTIS aims to: 1) develop a nuanced account of the diverse challenges facing academia and better understand emergent or successful responses and transformation; and 2) co-create possible and utopian academic worlds that open new horizons for meaningful discussions and paradigm-shifting actions that account for its current weaknesses and blind spots, particularly when it comes to gender and multispecies entanglements. ATLANTIS is anchored in anthropology and science and technology studies (STS) and focuses on three distinct but interconnected lines of inquiry about academia and its future at the present (neoliberal) moment. ATLANTIS takes a forward-looking approach that is historically and ethnographically grounded, while engaging innovative co-creation and future-oriented techniques articulated at the intersection of anthropology, innovation, and design. ATLANTIS is hosted at the Norwegian University of Science and Technology (NTNU) and includes a secondment at the University o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development and verification of microstructure, residual stress and deformation simulation capability for additive free-form direct deposition using multiple superalloys' (SUPERMODEL).

assistant: **Innovation**

SUPERMODEL will (1) develop a state-of-the-art microstructure evolution model for blown powder laser metal deposition processing and post-processing of multiple super alloys (including Inconel 718) that can predict grain sizes; orientation and texture; phase composition (including precipitation & particle size); and defect (pores and lack of fusion) distributions; (2) link the microstructure model to part-level (global) thermo-mechanical LMD process simulations to enable a direct coupling between continuum-scale stress-strain behaviour and the evolution of microstructural internal state variables; (3) validate the computational models through iterative, detailed and comprehensive experimental test programmes including in-line monitoring of melt pools, thermal transients, stresses and deformation; post-build, 3D scanning of part distortions; metallographic examination and CT scanning; and (4) demonstrate the predictive powder of the model on a complex part (curved substrate with angular features) incorporating two different superalloys with runtimes less than 5 days. This will be achieved through an ambitious numerical-experimental procedure leveraging design-of-experiments methodologies and iterative feedback between modelling activities and testing to develop a robust software system.SUPERMODEL contributes to the aims of the Clean Sky Engines ITD by providing experimental data and simulation tools that will enhance the reliability of additive manufacturing technology, thereby streamlining LMD part certification and qualification, minimises experimental trial-and-error along the way. SUPERMODEL will therefore make progress towards achieving the EC goal of moving from “Modelling-for-Industry” to “Modelling-by-Industry” which means shifting effort from laboratory- and RTO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Science, technology and civil society - Civil society organisations, actors in the European system of research and innovation' (STACS).

assistant: **Innovation**

The issue of civil society involvement in research has received little attention. But the European vision of a knowledge-based society demands early dialogue between scientists, policymakers and civil society. Increasing the societal relevance of research implies numerous questions: In which cases and how civil society can be fruitfully involved in the regulation and production of scientific knowledge' How to prepare civil society organisations (CSOs) to participate in foresight and science policy activities and in research projects' How to get scientists interested in projects with CSOs' How to make the case to policy makers for the constructive participation of CSOs in research' How to ensure that scientists and CSOs can build common projects for Framework programme 7 (FP7)' Our project will attempt to explore these questions we propose 1) training sessions on socially-important scientific issues to build the capacity of CSOs to approach scientific questions. 2) workshops serving as research project  nurse ries ", identifying research topics for co-operation between CSOs and public research institutions and aiming at involving CSOs in future research projects for FP7. 3) a website, lasting beyond the project, providing a European-wide platform for exchange between CSOs and scientists. 4)an analysis of the European research system, raising awareness for CSOs and strengthening their capacity to benefit from European research. 5) meetings with members of the European Parliament and officers of different DGs of E C (presentation of our findings, generate discussions on how to bring European research closer to citizens). Training sessions and workshops will identify ways to build links with research institutions and identify research groups interested in working wit h CSOs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Metabolic regulation of growth and body composition: key modulators of long-term health' (META-GROWTH).

assistant: **Innovation**

Nutrient exposure during pregnancy and childhood strongly affects growth and induces persistent metabolic programming of lifelong health. Recent data show that obesity and related disorders are induced by both fast childhood weight gain, and by formula feeding that promotes higher weight gain than breastfeeding. Lower protein in infant formula at levels similar to breast milk normalizes early weight gain and reduces later obesity risk as much as 2.5fold. Optimizing growth through improved substrate supply is of major importance for health prevention, but information is lacking on key mediators, effects on body composition and mechanisms of action, e.g. epigenetic modification. We use innovative approaches to identify key substrates that may mediate growth and body composition in humans, e.g. branched chain amino acids, n-6 polyunsaturated fatty acids, and others, and their epigenetic effects. We employ novel methods for high throughput targeted metabolomic and lipidomic profiling, genome-wide DNA methylation analysis, and state of the art bioinformatics. These powerful tools are applied to five well designed prospective cohort studies covering critical time periods from pregnancy to puberty. All cohorts offer precise phenotyping incl. body composition and are already or will be established. Comparative analyses across studies and populations provide added scientific value. We will identify which metabolic signals induce rapid weight gain and body fat deposition throughout childhood. We aim at identifying susceptible age periods, nutrient effects on epigenetic DNA methylation, and whether early metabolic exposures induce persistent or fluid metabolomic and epigenetic changes over time. The results should provide answers to key questions on the regulation of growth, with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Intelligent shuttle fleet connecting a split container storage area for intermodal operation improvement (ASAPP ONE)' (1998-2002).

assistant: **Concept**

This project proposes the solution the growth impossibility of the second rank container terminal due to space and traffic constraints. The system is a dedicated rail track (new or existing) connecting the port yard to a peripheral inland depot, operated by automated shuttles and managed optimising the line exploitation driving the shuttles from the front end to the loading bays also. The vehicle ASAPP One will run as autonomous shuttle or in a  convoy mode" without any mechanical link between the shuttle trains. The system will eliminate the road traffic problems in the urban areas surrounding the ports (> 2000 trucks/ day for a second rank port) in favour of the middle range railway transport. The consortium is formed by container handling machinery industrial companies, engineering houses, research institutes and intermodal business users. A validation field test will be done."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Structure-function-relationship of biomolecules probed by infrared spectroscopy' (1994-1998).

assistant: **Concept**

Vibrational spectroscopy, of which infrared spectroscopy is the most widely applicable, perfectly fills the gap between the structural techniques of X-ray crystallography and NMR, which yield frozen, static structures, and the time- resolved but structurally weak methods of UV/vis and CD spectroscopies. X-ray crystallography and NMR have provided many biomolecular structures while bound substrates and inhibitors have helped in defining the functions. In order to understand the functions of enzymes, redox proteins, DNA-binding proteins and other biological macromolecules in terms of structure, further spectroscopic probes are essential. Raman spectroscopy has fulfilled an important role in time-resolved studies but is applicable only in limited circumstances. IR spectroscopy provides a structural probe with time-resolution and can be used to determine protein secondary structure in equilibrium and on a time resolved basis (folding/unfolding), protein-ligand interaction in enzyme catalysis and inhibition, and the structural changes upon photo reactions and electron transfer reactions. A variety of IR instrumental methods (of which Fourier Transform methods are currently the most widely used) give versatile measurements at very high sensitivity and time resolution, with reasonable effort and cost, and will be applied to these topics in this programme. Isotope- editing coupled with difference methods will allow specific structural features to be highlighted against a dense spectral background, such as a ligand bound to a protein. The interaction of proteins with membranes as well as determination of the mutual perturbing effects of the interaction and the orientation of the protein with respect to the membrane will be measured. Band deconvolution, band fitting, and factor a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European value of a quality adjusted life year' (EUROVAQ) under Sixth Framework.

assistant: **Objectives**

A major issue in cost effectiveness analysis is that of the value to place on a quality adjusted life year (QALY), commonly used as a measure of health effectiveness across Europe. This has come to the fore in several European countries, resulting from the creation of national health technology and pharmaceutical assessment agencies. Such agencies were established to make recommendations on technology adoption, addressing issues of affordability and sustainability of publicly funded health care systems. Recommendations are most often made on the basis of QALYs produced relative to costs incurred. Methods of estimating cost per QALY, based on rigorous decision analytic models, are now very sophisticated. However, 'threshold' values adopted (such as £20-40,000 per QALY above or below which a new therapy will be rejected or recommended for adoption in England) are essentially arbitrary, with little or no economic foundation.This critical policy issue is reflected in growing interest across Europe in development of more sound methods to elicit such a value. The aim of this project would, therefore, be to develop robust methods to determine the monetary value of a QALY across a number of European Member States. This would be addressed in two ways: through 'modelling' such a value based on values of statistical lives currently used (or implicit values from adoption decisions in various fields) across Member States; and through survey research to test two methods of deriving a societal willingness-to-pay (WTP) based monetary value of a QALY. A European-level research initiative is required in the interests of subsidiarity and coherence. Different Member States will have different levels of affordability of QALY production. Country-specific values would lead to improve decision
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Biomedical CRMs for clinical diagnostics' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Specific Objectives- To provide a vital link for building a common reference system in the clinical chemistry sector not only within the European Research Area but also rather on an international level.- To provide clinical CRMs to users world-wide as required to support international health care and in co-operation with the IFCC;- CRMs for alpha amylase, first steps towards a calibration panel of glycated haemoglobin and the certification of RMs, such as cardiac markers (myoglobin), serum reference solutions and reference materials for genetic markers.Planned DeliverablesSpecific Deliverables to DGs- Production and short term stability of a Hb1Ac reference material;- Production and homogeneity study of a myoglobin reference material;- Completion of homogeneity and short term stability study of progestorone and total protein CRM;- Setting up the JCTLM committee under the auspices of BIPM to achieve a common reference system in the clinical sector.Deliverables as a result of the research- Finalisation of the commutability study on amylase;- Publication of 4 international reference procedures for enzyme activity measurements;- Progress report of the CRMGEN project (production of human DNA CRMs).Summary of deliverables made by: 31/12/2001Certification ASAT DG RTD/IFCCThe certification of ASAT reference material at 37°c instead of 30°c is now mandatory because most routine measurements of catalytic activity are carried out at this, the normal body temperature.ASAHI developed a recombinant material and has freeze dried a trial batch offering significant advantages compared to a liquid frozen material. If proven to be commutable and since ASAHI can only produce the material in screw cap vials IRMM will produce the material in ampoules and is awaiting information regarding the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel Receptor:Ligand Interactions in Osteolytic Diseases' (NRLIOD) under Seventh Framework.

assistant: **Objectives**

Pathological bone loss (osteolysis), the process whereby osteoclasts erode mineralised bone matrix, remains an unresolved challenge in the pathology of osteolytic diseases, such as osteoporosis, rheumatoid arthritis (RA) and osteolytic bone cancers. Identification of the receptors involved in osteoclast development (osteoclastogenesis) is currently a high priority in osteoclast research. The goal of this research is to identify and understand the receptors and ligands regulating osteoclastogenesis. The primary aim of this proposal is to identify how these osteoclastogenic signals operate in osteolytic diseases. OSCAR is an osteoclast receptor that delivers potent osteoclastogenic signals. I have discovered that type I-IV collagens (major structural proteins at sites of diseased joint and bone erosion) are ligands for OSCAR and drive osteoclastogenesis. This exciting new finding has changed our understanding of the environmental signals regulating osteoclastogenesis. I will use gene knockouts, mouse and human disease models to dissect the molecular interactions required for osteoclastogenesis using OSCAR as a model receptor/ligand interaction. Using these techniques, I will determine the role of the OSCAR, and other receptors, in osteoclastogenesis in vivo and in the diseased state.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New anaerobic bioprocess involving simultaneous sulfate reduction and ammonia oxidation.' to be submitted under Fifth Framework.

assistant: **Abstract**

A new bioconversion process involving the simultaneous oxidation of ammonia and the reduction of sulfates taken place under anaerobic conditions (redox potential of -425 mV) has been experimentally observed when treating industrial wastewater rich in organic carbon, nitrogen and sulfate. Experiments were performed in a Anaerobic Fluidized Bed Reactor (AFBR) filled with Granular Activated Carbon (GAC particles that were colonized by the biomass growing within the reactor. The mass balances of the different nitrogenous and sulfur compounds entering and leaving the reactor in the liquid and gas phases clearly indicated an uncommon evolution. An important percentage of the nitrogen entering the reactor as TKN (80% as ammonia) was removed from the liquid phase appearing as molecular nitrogen in the gas phase. Simultaneously, the sulfates entering the reactor disappeared being mostly transformed to elemental sulfur the rest appeared as sulfide in the liquid effluent or as hydrogen sulfide in the biogas. These experimental observations suggest a new anaerobic biological conversion involving simultaneous ammonium oxidation and sulfate reduction being ammonium the electron donor and sulfate the electron acceptor (Fdez.polanco et al. Water Research Vol.35(4) , pp.1111-1114, 2001).Keeping in mind this fascinating scenario we seek outstanding post-doctoral researchers with competence in environmental microbiology. Candidates must hold a Ph.D. on Environmental Microbiology or close related field. They will be assigned for describing and characterizing the microbiology involved in the process (here named SURAMOX) including the tracking of chemical intermediates and products generated in the SURAMOX process. Candidates are expected to possess expertise isolating and characterizing gro