RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Role of E3 Ub-ligases in TGF-beta signaling and tumorigenesis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The binding of TGF-b to its receptors induces phosphorylation of Smad2 and Smad3, their subsequent association to Smad4 and their nuclear translocation. In the nucleus, the Smad3/Smad4 and Smad2/Smad4 heterodimers act as transcription factors and induce specific target genes. TGF-b pathway has a tumor suppressor function characterized by its ability to inhibit cell growth. Many cancer cell lines have acquired resistance to the antiproliferative effect of TGF-b. This is mainly achieved through loss of function mutations or deletions that affect TGF-b receptors or Smad4, particularly in colon cancer and pancreatic cancer. During my Postdoctoral training in Caroline Hill’s laboratory, I have shown that the E3 Ub-ligase Arkadia is involved in the degradation of the transcriptional repressor SnoN and is therefore absolutely required for the activation of Smad3/Smad4 target genes such as PAI-1. The laboratory of Azeddine Atfi has recently performed a two-hybrid screen using another repressor of the pathway, TGIF, as a bait. This study has led to the identification of a new partner of TGIF, TIP11 (TGIF interacting protein 11), which is a new potential E3 Ub-ligase. Preliminary results indicate that TIP11 also contributes to TGF-b responses. Recently, we both have independently identified that Arkadia and TIP11 can be altered in tumor cell lines. Our study aimed to determine whether these two E3 Ub-ligases, essential for the TGF-b pathway, are novel tumor suppressor genes. Our objectives are: (1) to identify Alterations of Arkadia and TIP11 in human carcinoma cell lines and tumor samples. (2) to study the function of Arkadia and TIP11 by reintroducing Arkadia or TIP11 in deficient cell lines, in order to better understand their role in TGF-b signaling and tumorigenesis. (3) to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'THE NON-ABELIAN HODGE THEORY OF AN ORBIFOLD KLEIN SURFACE' (HORUS), addressing dissemination and exploitation.

assistant: **Impact**

For centuries, mathematical concepts have inspired technological progress. As the distance between fundamental research and applications shortens, the impact of mathematics on our everyday lives becomes stronger, and the long-standing European tradition of excellence in mathematical research reaffirms itself as a key factor of sustainable economic growth. In line with that tradition, the goal of the present project is to achieve and disseminate high-impact research results in the field of Differential Geometry, that will irrigate related disciplines, such as Theoretical Physics and, in the longer run, more applied fields. The applicant’s outstanding research record in Gauge Theory and Representations of Fuchsian Groups, combined with the expertise of his European hosts in the rapidly growing area known as Higher Teichmüller Theory, make the proposed collaboration between them unique, timely, and ideally shaped for success. The research results that they are setting out to obtain will redefine the field and open new lines of research. Moreover, the host institution is committed to providing high-quality training of the applicant at every step of the action, from concrete initiatives to reduce the gender gap in mathematical sciences to the use of technological tools for the dissemination and communication of research results. The completion of the present research project will thus bring a significant boost to the applicant’s career and establish the host institution as a pioneer in a new line of research, hereby strengthening its tradition of excellence and innovation. The project is in accordance with the recommendations of the 2016 consultation of the European Commission for Mathematics in Europe, according to which “the wealth of mathematical competence in Europe and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Process Intensification through Adaptable Catalytic Reactors made by 3D Printing' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Catalytic reactors account for production of 90% of chemicals we use in everyday life. To achieve the decarbonisation of European economy and comply with the 20-20-20 target, resource utilization and energy efficiency will play a major role in all industrial processes.The concept of PRINTCR3DIT is to employ 3D printing to boost process intensification in the chemical industries by adapting reactors and structured catalysts to the requirements of the reaction. This manufacturing technique is particularly useful in reactions where diffusion, mixing and/or heat transfer are limitations against reaching higher performance. The utilization of the concept of 3D printing will also reduce the resource utilization of reactor and catalyst manufacture, energy consumed (< 15%) and transportation.The rationale of using 3D printing will follow a generic and systematic structure for implementation. The methodology will be applied to three markets of fine chemicals, specialty chemicals and fertilizers, ranging from few tons to millions of tons of production per year. This demonstrates the enormous versatility of 3D printing for reactor and catalyst designs that cannot be improved with traditional building and design tools. For all these processes, the challenges to be solved are thermal management, innovative reactor design and flow distribution. These examples will provide realistic data in different markets to delineate business case scenarios with the options of new integrated plants or retrofitting for large-scale applications.Application of cutting-edge 3D printing to catalytic reactors will foster higher productivity, a more competitive industrial sector and higher value jobs in Europe - keeping leadership in such a challenging arena. PRINTCR3DIT is a joint effort between world-l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'circulaR bioecOnomy Business mOdels owned by agroCOOPeratives'.

assistant: **Innovation**

The bioeconomy roll-out on a large scale needs the establishment of new models and interactions between the primary sector and other stakeholders toward co-participated bioindustries.In this sense, ROBOCOOP-EU proposes a breakthrough cultural change in the agrosector, by deploying effective regional and circular bio-based Business Models for the valorisation of waste streams from 3 agricultural sectors: grape, olive and stone fruit. This will expand real scenarios of commercial opportunities to diversify the economy of small and medium scale farmers and cooperatives, enabling a more versatile biorefinery with a portfolio of biobased products. This model will allow the integration of secondary streams in a holistic closed loop, thus improving the ecological footprint and revenues with social impact. ROBOCOOP-EU will: involve 8 actors of the primary sector in the establishment of biobased value chains; avoid 25-30% of GHG emissions by means of supply chain and logistic optimisation; design 1 zero-waste multi-feedstock biorefinery at industrial scale (based on existing processes for biocompounds extraction and 2nd streams valorisation); validate 17 new products (3 food formulations, 3 feed additives, 5 cosmetics and nutraceutics, 1 plasticiser and 5 biofertilisers).In order to achieve a successful implementation of the business models in its 3 regional hubs (Extremadura, Apulia and Western Macedonia), ROBOCOOP-EU will integrate multidisciplinary knowledge by developing co-creative spaces called “Living Labs”, where partners and stakeholders will discuss and validate the most consensual pathway towards sustainable and profitable co-participated biorefinery and seek for public and private fund scheme workable scenario. ROBOCOOP-EU consortium is composed by 22 multisectorial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Indoor operation of 1000x multijunction cells by fibre transmission (PV-FIBRE)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The project proposes to develop an indoor cell receiver made of substrate plates carrying small high efficiency (30%) multi-junction solar cells operating at l000X using conventional two axis tracking low cost sunlight concentrators. The transmission of the concentrated light will be carried out by means of optical fibres that will share the beam focused on a transparent light to the indoor located cells. In this way, all the problems associated to outdoor operation are avoided with a better controlled indoors . The project will develop a complete 25% efficient system of 200 Wpeak, consisting of 200 monolithic ML cells each 5 mm2 in size, mounted on heat sink plates located indoor. The objective is to develop complete alternative concentrator systems for such cells, the most promising way today to reach cost competitiveness. Three R&D centres and a company, each specialised in every part of the project form this European consortium.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of a Rapid Test Kit and supporting Reference Standards Capable of Detecting the Emerging Fish toxin Ciguatoxin in European and Global Waters' under Seventh Framework.

assistant: **Concept**

This proposal, CiguaTools has been developed to deal with a serious emerging problem thought by many to be caused by climate change. Put in basic terms, strains of harmful marine algae which produce deadly toxins and were only associated with tropical climates are emerging in European waters. Due to the complexity of the food chain these toxins accumulate in fish. While the fish themselves show no obvious signs of contamination eating such fish can have very serious health implications. Ciguatera fish poisoning (CFP) is a major economic and social problem worldwide, with up to 500,000 people being poisoned each year. The associated illness caused by this can last for many months. The causative toxins are known as ciguatoxins (CTX).A consortium comprising experts in marine toxins, rapid screening test development and a group of  SMEs specialising in producing vital reference standards, test kits and validating both to international standards has been formed to deliver the following objectives:The identification of the CTX toxin profiles present in EU waters which will lead to the production of vital reference standards.The production of a fast and simple method for high throughput analysis for CTX toxin presence in fish destined for consumption.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'REvitalising tap WATER for reduced consumption of plastic water bottles' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The vision of Retap is to shift the consumption of water away from plastic bottles into environmentally sustainable alternatives. To do this, Retap is developing a solution that is able to convert the consumption of tap-water into a personalised health and taste experience. The aim is to make this solution a wide-spread product, and thereby reduce the consumption of plastic bottles on a global scale. Researchers and campaigners predict that the issue of plastic bottles is an environmental crisis as serious as climate change, as it pollutes every natural system and an increasing number of organisms throughout the planet. Therefore, the potential impacts of our Retap Pure solution are immense, as a switch away from plastic bottles to a tap-water based, environmentally sustainable solution would constitute a major leap forward in relation to solving one of the largest waste issues the world faces today.In this SME Phase 1 project, we will assess the technical feasibility of developing fast-dissolving mineral compounds and in integrating the SuperiorOsmosis technology into a machine infrastructure of the projected size (16.5x24x30cm), and the economic feasibility of assessing the exact production price-point. The outcome of the Phase 1 feasibility study will be a more elaborate business plan, which will include all relevant aspects in relation to the viability of the concept. Following a successful phase 1 feasibility assessment, we will pursue further investments and support, including from the SME Instrument Phase 2, in order to develop and market mature Retap Pure.Retap is an award-winning Danish SME that since 2009 have developed solutions for replacing bottled water with environmentally sustainable solutions. Our primary product is the Retap Bottle, which is a durable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'COmbatting disorders of adaptive immunity with Systems MedICine' (COSMIC) targeting Horizon 2020.

assistant: **Abstract**

Background: EU countries face large health challenges to combat chronic diseases. Recently, systems medicine has emerged as a promising discipline to accelerate the translation of basic research into applications for improved diagnostics and personalized treatment. Its power arises from the integration of laboratory and computational approaches crossing research disciplines and sectors to solve clinical questions. COSMIC delivers the next generation of leading, entrepreneurial, and innovative systems medicine professionals having expertise, skills, and experience to successfully combat complex human disorders. These professional will find excellent career opportunities. COSMIC focuses on B-cell neoplasia and rheumatoid arthritis, prototypical diseases originating from abnormal functioning of immune cells, often resulting in similar antigen specificities. COSMIC enables Early Stage Researchers to play a leading role in this exciting field.Approach: COSMIC develops and integrate experimental and computational approaches and establish a unique cross-fertilization between oncology and auto-immunity. In addition to transferable skills, the training program focuses on establishing a double expertise in laboratory and computational to address clinical questions. It involves a wide-range of stakeholders: (pre)clinical departments, companies, patient groups, students, and the general public. COSMIC will establish a link with the leading European EASyM and ISBE initiatives, and aims to harmonize systems medicine training throughout Europe by connecting to other EU (Marie Curie systems medicine) training initiatives.Impact: COSMIC (i) significantly improves ESR career perspectives (ii) leads to new public-private collaborations increasing competitiveness for companies; (iii) contr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'NanoMaterials Enhanced Membranes for Carbon Capture' (NanoMEMC2) targeting Horizon 2020.

assistant: **Abstract**

Membrane separation processes can be applied to many capture processes from Pre-Combustion ( CO2-H2 / CO2-CH4 separation) to Post-Combustion (CO2-N2) and Oxyfuel (O2-N2) and are generally endowed with high flexibility and potentially low operative costs with respect to other capture methods. However the current materials are still lacking of separation performance and durability suitable for an efficient and economically feasible exploitation of such technology. The Project NANOMEMC2 aims in overcoming the current limitation focusing on the development of innovative CO2 selective membranes with high flux and selectivity suitable for application to both Pre and Post-combustion Capture processes.To that aim nanocomposite or mixed matrix membranes will be considered with particular focus on facilitated transport mechanisms promoted by carrier attached to the polymer or the filler. Graphene based nanosheets and cellulose nanofibres will be studied in detail considering their possible modification to improve polymer compatibility and affinity with CO2. A new generation of Facilitated Transport Mixed Matrix ( FTMM) membranes for CCS applications will be developed with increased CO2 flux and selectivity beyond the current target for industrial deployment of carbon capture membrane technologies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cubbit -  the first distributed data-center recycling the internet resources we waste into the most competitive cloud provider.' (2014-2020) under Horizon 2020.

assistant: **Objectives**

All companies using cloud services look for excellent performances, competitive prices, and the highest standards of privacy. Yet, no cloud provider is currently able to provide all these three benefit together. This pain point arises because the current standard of centralized cloud (i.e., one proprietary web farm serving millions of users) has huge operating costs and recurring weaknesses concerning data security.Cubbit develops a technology able to disrupt the global cloud industry by replacing the root cause of its problems, i.e., centralized server farms, with a distributed data center based on a peer-to-peer network free from infrastructural costs, highly scalable, and secure by design.Cubbit turns the storage, CPU, and bandwidth provided by its users - who access the first ever forever-free end-to-end encrypted cloud storage service - into professional web services sold to SMEs customers - who finally get a secure, efficient, and inexpensive cloud.While around 70% of the revenues made by traditional cloud providers are burnt into direct operating costs, Cubbit is the first provider that turns the costs into a revenue stream as it gains a margin on every domestic server activated.Cubbit is also environmentally sustainable, using up to 10 times less energy than centralized cloud. For every TB you store on Cubbit, you save the gross equivalent to 100 kgCO2/year.Founded in July 2016 and based in Bologna, Italy, the company is the first Italian startup ever invested by Techstars & Barclays’ accelerator in Tel Aviv, Israel, a world-class program focused on cybersecurity. It is now backed by 2 VC funds and private investors.In March 2019, Cubbit run a successful product-crowdfunding that hit +821% overfunding and entered the top 1% of most funded Kickstarter campaigns o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Optimal Person-Machine Sensorimotor Coupler for Application to Micro-Manufacturing' (RELAX), addressing dissemination and exploitation.

assistant: **Impact**

Micro-manufacturing is a key sector for the EU industry. Enabling flexible, cost efficient, and compact production is essential to gain competitive edge and leadership in the manufacturing of high value-added miniatur- ized products. The manual, high-precision assembly or manipulation of micro-parts required for miniaturized assemblies is required by several markets. Companies using micro-mechanical processes, such in horology, or miniature devices employed in the aerospace and defense industries, are in great need of semi-automated manufacturing solutions to increase their productivity and lower the costs. This constraint follows naturally from the nature of their products which are manufactured in moderate quantities and in many variations. The manufacturing of such goods would be greatly aided by the availability of semi-automated robotized workstations that are flexible and capable of moderate to high production volumes. Semi-automation means that human intervention plays a key part in a manufacturing process even if some sub-tasks, such as axle insertion in micro-assembly, can be automated. Recent advances achieved under “Computational Theory of Haptic Perception” led by V. Hayward (Advanced Grant 247300) have elucidated a completely new role for afferent, sensory information during movement that mirrors the role of movement during the elaboration of haptic (tactile) percepts. The technology that we have developed, and patented, eliminates the sensory interference from the interaction between the user and a task. The user is in a position to interact with the micro-parts as if they were scaled by a very large factor, with the consequence of letting the sensorimotor system of the user operate in optimal conditions. The project is motivated by the combination of a ba