RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Outer membrane protein complexes of mycobacteria' (MYCOOMP) targeting Sixth Framework.

assistant: **Abstract**

Tuberculosis is a severe human disease and the appearance of a growing number of multiple-drug resistant Mycobacterium tuberculosis strains makes it a necessity to learn more about cell wall formation, drug uptake and drug mechanisms. A major hurdle for the development and improvement of newug candidates is the notorious difficulty in identification and characterization of the corresponding drug targets in M. tuberculosis. This limitation results mainly from the fact that we do not yet have the means to study protein function and protein-protein interactions within the mycobacterium itself. We therefore propose to develop a novel approach to study protein-protein interactions in living mycobacteria which addresses this important need. The approach is based on a recently developed fusion tag that can be labelled with a variety of chemically diverse compounds in living cells. The labelling of a protein of interest in living mycobacteria with a reactive oxygen species-generating photosensitizer and the subsequent proteome-wide detection of protein modifications by reactive oxygen species should allow the identification of proteins that are localized in the direct vicinity of the labelled protein of interest. The application of this technique to proteins associated with the outer membrane of mycobacteria should allows us to identify and characterize new mycobacterial outer membrane proteins and protein complexes, thereby yielding new insights into the biochemical features of the highly complex and unusual structure of the mycobacterial cell wall. Only the discovery of new mycobacteria-specific drug targets will lead to the development of new drugs for a better treatment of tuberculosis. In addition, this new technology should be applicable to the identification of protein-p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fluorescent nanocrystals for activation and delivery of platinum drugs' under Seventh Framework.

assistant: **Concept**

Chemistry has made major contributions towards fighting cancer (Europe's major cause of death) by developing small molecules which can act as anticancer drugs. But despite extensive research efforts, defeating cancer is proving to be an enormous challenge. Inorganic chemistry has made its most important contribution in the form of platinum (Pt) complexes, which provide highly effective chemotherapy for testicular, ovarian, neck, cervical and esophageal cancers. Drug resistance and toxic side effects means that there are many occasions when Pt-based treatment must be discontinued and limit the ability of Pt drugs to cure other forms of cancer such as the more common colon and breast cancers. The problem is that the drugs are not ‘smart’ – they are not capable of identifying cancer cells and they react with a wide range of molecules. Another significant limitation is that it is not possible to control when and where they exert cytotoxicity. Here we propose a novel methodology to make: 1) Pt complexes capable of identifying cancer cells, 2) Pt drugs with a built-in security device –a switch which we can turn on externally to make the Pt drug active only when it reaches the tumour.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Interaction between the protein repair enzyme L-isoaspartyl methyltransferase and insulin/IGF-1 signaling in mice and worms'.

assistant: **Innovation**

The protein L-isoaspartyl methyltransferase (PIMT) is well known for its protein repair function, namely the reconversion of deamidated and/or isomerized asparaginyl and aspartyl residues (L-isoaspartyl residues) into their normal, non-isomerized forms. The conversion of biomolecules to non-useful and potentially toxic products by unwanted chemical reactions represents probably an important aspect of the aging process in living organisms. To the extent that they can minimize the accumulation of damaged molecules, they can endure. PIMT knockout mice accumulate high levels of damaged proteins in their tissues, especially the brain, and die of massive seizures at an average age of 42 days. On the other hand, worms and flies overexpressing this enzyme live longer, strongly suggesting a role for PIMT in the aging process. A particularly intriguing observation is that the insulin/IGF-1 signaling pathway is activated in the brain of PIMT knockout mice. Genetic evidence also exists for an interaction between PIMT and insulin-like signaling in Caenorhabditis elegans. It has recently become clear that insulin-like signaling plays an important role in the regulation of the aging process. Lowered insulin/IGF-1 signaling, especially in neuronal tissues, leads to lifespan extension in worms, flies and mice. The overall objective of this project is to understand the link between PIMT and insulin-like signaling. A first aim is to consolidate the interaction between PIMT and insulin-like signaling in worms. A second aim is to analyze the effect of PIMT deficiency on the phosphoproteome of mouse brains. A third aim is to elucidate the mechanism by which PIMT deficiency leads to the observed changes in protein phosphorylation. Several routes, including direct regulation of protein phospha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'VISION for RETAIL'.

assistant: **Innovation**

One of the major pain points in retail is the lack of speed and precision in information from the selling floor. Acquiring accurate and real-time feedback on inventory distortions, such as out-of-stock, overstock and misplaced items is of paramount importance for all retail operations. This has been pinpointed as an $800 billion global problem for wholesalers, market researchers and retailers. The current practice of supermarket shelf monitoring and auditing relies on the visual inspection of supermarket shelves by a human auditor. This visual inspection mainly involves recognizing packaged products displayed on the shelf and producing an approximate shelf share value for each. The main concept of our innovative solution is to transfer this visual recognition task performed by the auditor to our computer vision based visual recognition software service, which can produce much more accurate and much more detailed counts using a few digital pictures of the supermarket shelf. We think such a service will ease many of the labour intensive problems in retail auditing and consequently be extremely beneficial for our target customers consisting of wholesalers, market research companies and retailers. We have already developed a prototype system for computer vision based automated supermarket shelf monitoring and has tested this prototype in a pilot study carried out jointly with an international market research company. We have therefore shown the technical feasibility of the innovation. At the current stage, we aim at carrying out a feasibility study with two-fold objectives: (1) An extensive analysis of the target markets, (2) A concurrent scalability analysis of the solution in terms of operational and financial aspects. These two objectives will lead to an elaborate busine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Generic approach to manufacturable optoelectronic interconnects for VSLI circuits' to be submitted under Fourth Framework.

assistant: **Abstract**

In this project, we want to find solutions to the difficulties of electronic interconnects to handle high throughput data transfer within and between silicon VLSI chips. This fundamental problem arises from the ever increasing IC complexity, speed and interconnection requirements. Several European research projects (e.g. OLIVES, HOLICS and SPIBOC) have proposed optical solutions to this interconnect bottleneck at a higher level of interconnect hierarchy (inter-cabinet and back plane interconnects). It is the main goal of this project to establish key technologies and define relevant processing architectures allowing introduction of area (as opposed to edge) optical interconnections for intra- and inter-MCM data exchange.The data rate per channel will be compatible with extrapolated CMOS clock rates (0.5 to 1.5 GHz) and the number of interconnects will be in the 100 to 1000 range, leading to aggregate bit rates in to order of 100 to 1000 Gb/s. This will alleviate the interconnection problems imposed by purely chip edge electrical interconnects, enhancing processing power beyond performances offered by purely electrically interconnected VLSI chips.The project will demonstrate the advantages of high-throughput optical chip-to-chip interconnects by integrating area optical interconnections with standard (i.e. foundry based) CMOS chips, also addressing cost effectiveness as well as manufacturability. Processor architectures where the area optical interconnects offer substantial benefits will be identified. A CMOS VLSI chip will be designed, implementing at least partly such an architecture, and equipped with integrated analogue driver and receiver circuitry to interface the digital processing module to the optoelectronic components. Source arrays (VCSEL and LED arrays) and d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SHAPE - Situating Hybrid Assemblies in Public Environments' (SHAPE).

assistant: **Innovation**

SHAPE is devoted to developing and evaluating assemblies of hybrid, mixed reality artefacts in public places. Hybrid artefacts exhibit physical and digital features and can exist in both physical and digital worlds. They combine interactive visual and sonic material with physically present manipulable devices. Hybrid artefacts can combine to form room-sized assemblies that provide groups of people with a rich sensory experience of a large-scale mixed reality. These assemblies can be deployed in public spaces such as museums and exploratoriums as new kinds of engaging and educational social experience. The consortium combines social and computer science expertise and is concerned to motivate innovation through studies of people's activity in public places and techniques of participatory design. 'Living exhibitions', where results are shown direct to the public, are planned at selected European museums that have agreed to participate. SHAPE is devoted to developing and evaluating assemblies of hybrid, mixed reality artefacts in public places. Hybrid artefacts exhibit physical and digital features and can exist in both physical and digital worlds. They combine interactive visual and sonic material with physically present manipulable devices. Hybrid artefacts can combine to form room-sized assemblies that provide groups of people with a rich sensory experience of a large-scale mixed reality. These assemblies can be deployed in public spaces such as museums and exploratoriums as new kinds of engaging and educational social experience. The consortium combines social and computer science expertise and is concerned to motivate innovation through studies of people's activity in public places and techniques of participatory design. 'Living exhibitions', where results are shown di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Improved experimental and theoretical tools for helicopter aeromechanic and aeroacoustic interactions'.

assistant: **Concept**

Objectives and content:The main industrial objectives of the proposed project is to assure and improve safety, public acceptance and economic/technical efficiency of current and future helicopters. For this reason, the proposed research activities are targeted to avoid technical problems from the beginning of development of anew helicopter or to overcome problems appearing during flight-testing in short time.In order to be able to do so, the following targets have to be attained:- Acquisition of knowledge about specific interference and coupling phenomena, - Validation of existing wind tunnel test methodology and its extension to higher complexity, - Verification and extension of existing comprehensive theoretical models, - Definition of design criteria and know-how about the technical potential of future helicopters.In order to effectively perform the envisaged investigations, the participants will take advantage of different European wind tunnels and helicopter models, particularly suited for the different problems.These may be characterised in the following:- Effects due to low speed interference:- vehicle pitch up during transition from hover to forward speed, (task 3.1with generic rotor/fuselage model in 24ft DRA wind tunnel);- control problems by main/tail rotor interaction during quartering flight(task 3.2 with generic main/tail rotor model in 24 ft DRA wind tunnel);- control problems and extreme bank angles during sideward flight (task3.3 with B0105 model [with main/tail rotor] in DNW);- Effects appearing over larger areas of the helicopter flight envelope:- tail shake (by interference between hub/pylon wake and tail planes),(task 4.1 with DAUPHIN model [with main rotor] in ONERA S2 wind tunnel);- tail rotor noise (heavily influenced by the main rotor wake) (tas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Poly(catechol)-Lignin Hybrid Electrodes for Sustainable Batteries' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Designing safe and sustainable batteries is of great importance for sustainable development of our modern society. Hereof, rechargeable aqueous metal-polymer batteries (RAMPBs) that combine inherently sustainable redox-active polymer (RAP) organic cathodes, safe and abundant metal anodes in water-based electrolytes are identified as promising candidates. However, to date, most of the tested RAPs are synthetic ones, and their commercial exploitation hasn’t been accomplished due to high cost/performance factor. SUBPOL proposal aims to develop sustainable RAMPBs by hybridizing cost-oriented biopolymer (Lignin; Lig) and performance-oriented synthetic RAPs (PolyCatechols; PC) into organic cathodes, and combining with appropriate metal anodes (Zn, Pb, etc), targeting their performance beyond state-of-the-art (150–600Wh/kg, ~$150/kWh). SUBPOL will follow an integrated approach of macromolecular engineering-tailor made PCs, biopolymer platform-ease of Lig modification, novel electrode fabrication methods-LbL of complimentary charged PC and Lig polyelectrolytes or polyelectrolyte complexes and device optimization. This Fellowship will provide ER strong technical, professional and transferable skills, especially with acquisition of biopolymer batteries and scale-up, which will complete his practical expertise in synthetic RAPs, their applicability in different batteries. The success of SUBPOL depends on material design, device fabrication, scale-up, and all members of this consortium: Dr. Patil-ER, supervisors, Prof. Crispin-Linköping University at host, Dr. Marcilla-IMDEA Energia (secondment), Dr. Nilsson-Ligna Energy (placement in non-academia) have already demonstrated required skills in this regard. Optimistically, SUBPOL will cover some of the priorities of HE-WP for energet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identification of new components of the polarity pathway in drosophila', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The control of cellular polarity is one of the least understood aspects of development la Drosophila, like in all insects ia general the right stablishment of planar polarity in epithelial cells leads to the existence of regular arrays of bristles and hairs in wings, legs and body in genmal and the precise spatial arrangement of ammatidia in the adult eye. Little is known about the genes controlling such process. Mutations ia genes like dsh and RhoA, and genetic interactions among them, suggested the existence of a Fz/RhoA signaling for for the stablishment of polarity, which could have some analogies to the JNK signaling pathway partially dissected for a very different process occurring during Drosophila development, dorsal closure. This cascade would be also equivalent to the yeast pheromone signaling pathway and to the SRF activation pathway in vertebrate cells. The main objectives of this project are:1. To determine whether the known components of the JNK pathway involved in dorsal closure have a role in the establishment of tissue polarity.For this' we wil analyze the effect of loss of function of these genes in the adult eye and in the wing, to check whether we can detect a disruption of the regular arrangement of ommatidia or bristles in the mutant tissue.2. Identification of new components involved in polarity signaling.To do this we will perform a genetic screen looking for external modification of the gain of function phenotype of the small GTPase Racl (in which polarity is affected). We will use a collection of P lethal insertions to look for lines which dominantly interact with the tester stock These lines will represent mutant alleles of potential members of the polarity pathway, which can represent new alleles of already kno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'An integrated set of training courses for off-site emergency management in Europe' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The proposal aims at organising an integrated set of training courses for nuclear off-site emergency management in Europe. The series of three courses will be beneficial to those dealing with (aspects of) nuclear emergency planning and management and will be open mainly to participants from the EU and Central and Eastern Europe. The objective of the first course is to give a comprehensive overview of the fundamentals of emergency planning and response. The second and third courses will build on the first course and provide both, training for RODO S users on how to assimilate best the system results in decision making on interventions, and information and training in early and late phase issues by performing exercises using RODOS as didactic tool. These two training courses will be capable of being customised to national conditions (e.g. where RODOS has been implemented for operational use).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Next-generation polymer nanofibers: from electrified jets to hybrid optoelectronics'.

assistant: **Objectives**

This project ultimately targets the application of polymer nanofibers in new, cavity-free lasers. To this aim, it wants to tackle the still unsolved problems of the process of electrospinning in terms of product control by the parameters affecting the dynamics of electrified jets. The electrospinning is based on the uniaxial elongation of polymeric jets with sufficient molecular entanglements, in presence of an intense electric field. It is a unique approach to produce nanofibers with high throughput. However, the process is still largely suboptimal, the most of nanofiber production being still carried out on an empirical basis. Though operationally simple, electrospinning is indeed complex as the behavior of electrified jets depends on many experimental variables making fully predictive approaches still missing. This project aims to elucidating and engineering the still unclear working principles of electrospinning by solutions incorporating active materials, with a tight synergy among modeling, fast-imaging characterization of electrified jets, and process engineering. Once optimized, nanofibers will offer an effective, well-controllable and cheap material for building new, cavity-free random laser systems. These architectures will enable enhanced miniaturization and portability, and enormously reduced realization costs. Electrospun nanofibers will offer a unique combination of optical properties, tuneable topography and light scattering effectiveness, thus being an exceptional bench tool to realize such new low-cost lasers, which is the second project goal. The accomplishment of these ambitious but well-defined objectives will have a groundbreaking, interdisciplinary impact, from materials science to physics of fluid jets in strong elongational conditions, from proce