RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Sensing, monitoring and actuating on the UNderwater world through a federated Research InfraStructure Extending the Future Internet'.

assistant: **Innovation**

We must learn to both sustainably exploit & protect our vast oceans, provider of oxygen, food, hydrocarbons & other resources. A solution lies in sensing & interacting through an Internet of Things, with distributed networks of intelligent sensors & actuators.  Unfortunately, we currently lack a marine Internet, crucial to achieve distributed, coordinated & adaptive control, due to the rapid absorption of light & radio waves in seawater.<br/>The SUNRISE objectives are to develop:5 federated underwater (UW) communication networks (CommsNet), based on pilot infrastructure already designed, built & deployed by consortium partners, in diverse environments, web-accessible & interfaced with existing FIRE facilities to experiment with Future Internet technologies.A software-defined open-architecture modem & protocol stack that will empower open collaborative developments.Standard platforms for simulation, emulation & replay testing to estimate CommsNet performance at a fraction of current at-sea experiments, validated by tests conducted on the SUNRISE networks over a variety of applications & environments.A user-friendly interface for diverse users to interact with SUNRISE systems to conduct trials & benefit from databases of CommsNet performance data gathered over long periods from the SUNRISE infrastructure.<br/>SUNRISE directly addresses FIRE objectives by combining technology with novel paradigms in new, open experimental facilities, integrating physical systems with software development in a new physical domain.  SUNRISE will provide a way to select UW CommsNet standards based on objective measures of performance, strengthening as more sites are added in the future. The SUNRISE network will remain key for UW Internet development long after the project ends, with broad inv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Measuring GENomic diversity change over time in avian enDANGERED species' (GENDANGERED) targeting Horizon 2020.

assistant: **Abstract**

Biodiversity is declining at alarming rates mostly due to anthropogenic impacts, such as climate and land-use change. This in turn generates reductions in the genomic diversity that species require to persist and adapt in the face of future environmental change. Thus, a thorough understanding of how genomic diversity changes in the face of species’ declines is essential for planning conservation actions. The use of genetics in conservation biology has been extremely valuable in recent decades, and the quick adoption of cutting-edge genomics tools offer new and powerful insights, however, important challenges are yet to be tackled. Crucially, the conditions that lead to genomic diversity decline, and the details of how exactly genomic diversity is lost in response to population decline are currently unknown.  Current approaches focusing on reduced portions of the genome, and/or limited to the use of contemporary samples, are not enough. To fill these gaps in knowledge, I propose a plan that combines computer modelling with empirical genomic data to unveil signatures of genomic diversity change over time after recent global environmental change. The proposal consists of three complementary steps. (1) Simulate how genomic diversity declines across the genome according to different demographic models. (2) Obtain the first directly observed estimates of the pace, amount and type of genomic diversity change using whole-genome sequencing from historical (i.e. pre-decline) and contemporary (i.e. post-decline) avian samples. (3) Simulate common conservation practices to develop a predictive modelling tool capable of guiding conservation management in light of future environmental change. Altogether, this approach will allow me to dissect how genetic diversity is lost across the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Multistage Logic Platforms'.

assistant: **Objectives**

Microfluidic technologies offer significant advantages in crystal growth design and guided assembly when compared to conventional synthetic methods. For this reason, the motivation of the present project will be leaded to construct microfluidic platforms, hereafter called Multistage Logic Platforms (MuLoPla), where site-specific crystal growth, different patterns, and multiple template assemblies can be feasible in a single chip and on a surface. Among others, charge transfer complexes, charge transfer salts, and metal-organic frameworks will be the scope of the present project due to their broad interest in areas comprehending chemistry, nanotechnology, materials science, and physics communities. Furthermore, a premise of the proposed project will not just be a localized crystallization of functional materials, but their integration to read out components (i.e. electrodes) will be envisioned in a single MuLoPla.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Diversification with crambe; an industrial oil crop'.

assistant: **Innovation**

Crambe is a 'new' spring oil crop, suitable for diversification, which was first investigated in national and EU programmes (ECLAIR nø 0046 and Concerted Action AIR3 CT 2480). Seeds can be easily processed using conventional crushing and solvent extraction techniques, yielding oil and proteinic meal. The seed contains about 35% oil, which has a fatty acid composition of ca. 60 % erucic acid. This fatty acid is also found in High Erucic Acid Rape (HEAR) oil, although at lower concentration (ca. 45%). However, high and low erucic acid oil seed rape are cross fertile, and therefore the composition of seeds from neighbouring fields cannot be guaranteed. Thus the two rape genotypes cannot be cultivated in the same area. Crambe does not cross pollinate with rape and thus it can be cultivated in the same areas (North and Atlantic Europe). Further more, due to its Mediterranean origin, crambe is also well adapted to marginal land areas with mild winters and hot and dry summers. Cold tolerance would increase the locations where crambe can be successfully cultivated and may enable it to be grown as an overwintering crop. The use of erucic acid in lipochemistry is well established and an increasing market for this compound already exists. Recent experiments, carried out during the Concerted Action in co-operation with some private companies, showed that crambe oil can effectively replace mineral oil in many mechanical industry processes, viz. Metal working, lubrication, quenching, cutting, etc.  The proteinic meal contains about 6% of glucosinolates, which during processing, are hydrolysed into antinutritional compounds which reduce the nutritional value of meal for animal feed. During the Concerted Action, we developed a detoxification method, but in the longer term, the best sol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Composition, Decision-Making and Effectiveness of top Management Teams' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and contentBy using data set as already created at IMI and the Institute of Work Psychology, we will study how the composition (size, diversity, professional backgrounds) and decision-making processes of top management teams influence their effectiveness and the performance of their companies.Questionnaire data held at IMI and extensive videotape data of top management team decision-making will be augmented by further data gathered from top management teams in Ireland in order to determine how team composition, decision-making and other group processes influence team and company performance.Training content (objective. benefit and expected impact)Those in the IMI will be trained in the use of multi-media decision-making simulations to study) top management teams functioning. Theoretical bases for research on teams: group decision-making, team effectiveness and innovation will also be thoroughly described. Methods for undertaking detailed analysis of top management team decision-making and functioning will also be shared with researchers in the host institutions.Links with industry / industrial relevance (22)The research will be conducted in collaboration with top management teams in Eire and will involve feedback to those teams on their programme. The teams will be involved in the execution of the project and in helping to disseminate the results of the work.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes'.

assistant: **Objectives**

RationaleThe inability of pre-clinical studies to predict clinical efficacy is a major bottleneck in drug development. In severe asthma this bottleneck results from: a lack of useful and validated biomarkers, underperforming pre-clinical models, inadequate and incomplete sub-phenotyping, and insufficient disease understanding.HypothesisThe use of biomarker profiles comprised of various types of high-dimensional data, integrated with an innovative systems biology approach into distinct phenotype handprints, will enable significantly better prediction of therapeutic efficacy than single or even clustered biomarkers of one data type and will identify novel targets.StrategyU-BIOPRED proposes a staged-strategy:I)Generating an international consensus on diagnostic criteria for severe asthma.II)Unbiased discovery of sub-phenotypes of severe asthma in adult and paediatric patient cohorts using biomarker profiles (“fingerprints”) and systems biology to define “phenotype/handprints”.III)Validating the handprints for exacerbations, disease progression, and experimental challenges.IV)Using the handprints to improve human/animal in vivo and ex vivo models.V)Establishing the responsiveness and predictability of the handprints in gold standard and experimental therapeutic interventions.VI)Refinement of the diagnostic criteria and definition of severe asthma sub-phenotypes by incorporating the handprints, thereby enabling more focused drug development and faster delivery proof of concept for novel drugs.VII)Education, training and dissemination through a stakeholder platform and academic-industrial exchange, with potential for further growth as appropriate.Innovative approachWe will use a novel systems biology approach to integrate high dimensional data from invasive, non-invasive and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'IRB Barcelona International Postdoctoral Programme' in the context of a Seventh Framework call.

assistant: **Objectives**

IRB Barcelona is an independent, non-profit research institution engaged in basic and applied biomedical science at the interface between biology, chemistry and medicine. One of the main missions of IRB Barcelona is to provide young life scientists with the opportunity to do training and research in a unique and multidisciplinary scientific environment. The Institute has a young but well-established international PhD fellowship programme. After having consolidated our PhD Programme and achieved excellent results, our aim now is to draw on the strength of this example and enhance structures and resources for researchers at the next stage of their careers. Our goal is to offer postdoctoral fellows an optimal scientific environment at this critical time in their career and to prepare them on their journey to take up positions as independent scientists. With this objective, the contribution from the COFUND action will create a new fellowship programme for postdoctoral fellows. The IRB Barcelona International Postdoctoral Programme will offer 8 two-year competitive fellowships in the first call (2010-2011) and 10 two-year fellowship in the second call (2011-2012), based on the Incoming mobility trans-national element. The programme aims to highlight the attractiveness of our Institute to high-talented scientists, increasing European-wide mobility possibilities for training and career development of experienced researchers. Fellows will be selected through an international committee of experts, ensuring transparency and equal treatment of all applications. The programme will be promoted internationally. Applicants will receive support throughout the selection process and awardees will be helped and mentored for the duration of the fellowship period. Postdoctoral fellows under
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'DEVELOPMENT OF A TECHNOLOGY TO PRODUCE MICROCAPSULES, based on the formation of drops from viscous non-Newtonian liquids sprayed through fan-jet nozzles, TO USE IN CANCER THERAPY'.

assistant: **Concept**

The main aim of this project is the development of a new technology to produce smart drug deliverysystem for chemotherapeutic agents per recognition event. For that affinity-microparticles (10-20 micronsdiameter) loaded of paclitaxel (PTX) or Endotastin will be produced.Microcapsules will be made using a new technology based on the formation of drops from viscous non-Newtonian liquids sprayed through fan-jet nozzles. This process is based on generation of kinetic energy to aliquid jet resulting on controlled spray generation. The technique will be modelled in order to ensure the scale-upthe process.The microparticles, based on alginate polymer, will be functionalised on his surface by affinity ligand, epidermalgrowth factor (EGF) which will be able to recognize a specific protein of the tumoral cell, (EGFR) epidermalgrowth factor receptor.Surface plasma resonance will be carried to control the interaction between the microparticle and the protein andtherefore to ensure the efficiency of the microparticles produced. This information will be used to developed adynamic model to assess the importance of spatial phenomena and then we will evaluate the accuracy of partialdifferential equations (PDEs) in transient when spatial effects are important.Control release from microcapsules loaded of anticancer agent will be characterized by control release kinetics,mass transfer, mechanic stability and permeability studies. Mass transfer through the tissue, or therapeuticleakage from storage cavities and their consequent transport through the organ, are among the several physicalprocesses, where knowledge of the unsteady transport of a scalar quantity (mass of an active) is of importancefor cell therapy. For that reasons it is necessary to derive an analytical solution for the unstea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Access to neutron scattering and imaging facilities at orphee-laboratoire leon brillouin' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

LLB is a major Research Infrastructure devoted to the study of condensed matter by thermal neutron scattering. The neutron beams used by LLB are produced by the reactor ORPHEE which has a maximum thermal flux of 3.5 1014n/cm2/s. ORPHEE, the most recent and the highest flux medium size reactor in Europe, is equipped with two cold sources (liquid H2, 20 K) and one hot source (graphite, 1400 K), allowing to produce neutrons with wavelengths ranging from 0.5 to 20Å. 25 neutron scattering and imaging instruments, running simultaneously, are opened to EU users of the member states and associated states: 4 powder diffractometers, 3 single-crystal diffractometers, 2 materials science diffractometers (strains , textures), 4 small-angle scattering instruments, 2 reflectometers, 4 three-axis instruments, 1 time-of-flight and 2 spin-echo spectrometers for inelastic scattering, 2 diffuse scattering diffractometers and 1 Neutron Radiography imaging facility. Several instruments use polarized neutrons. The LLB instruments are equipped with many facilities such as cryostats and furnaces, high pressures and high magnetic fields.Written proposals have to be sent before October 1st and April 1st of each year. Proposal forms can be obtained from and must be sent to the Scientific Secretariat of the LLB. Call for proposals for potential users will be published in Nature, Neutron News, Physics Today and Europhysics News, and advertised on a dedicated web page on Internet. Project Manager: Pierre MONCEAU Director of LLB CEA/SACLAY/F-91191 Gif-sur-Yvette/France Tel: 33-1-69083254 (Secretary: Mrs Claude ROUSSE: Tel.: +33-1-0169085417) Fax: +33-1-69088261 E-mail: monceau@llb.saclay.cea.fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Demonstration of safety and efficacy of an anti-tumor therapy based on plasmoviruses expressing Apoptin R' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The main objective of this project is to demonstrate that our biotechnological product, our plasmovirus expressing Apoptin(r):  - is effective and safe in animal cancer-models and - can be produced at an industrial scale. - to be able to initiate and raise funds for Phase I and II clinical trials with patients suffering cancers  The project brings together three SME's, LEADD BV, Leiden, The Netherlands, GENOPOIETIC/SARL, Paris, France and BIOTECNOL, Lda, Porto Salvo, Portugal. All SME's originated and developed in the vicinity of academic centers of excellence. Two Universities, PIERRE ET MARIE CURIE UNIVERSITY, Paris, France and LEIDEN UNIVERSITY, Leiden, The Netherlands, both harboring an Academic Hospital are partner in this project..  GENOPOIETIC/SARL has generated the novel gene transfer vector system, which is called plasmovirus. It combines the simplicity of plasmids, with the infectivity and long-term expression of retroviruses. The plasmoviruses represent a new generation of gene-therapy vectors, which should be easy to produce in large quantity as clinical grade materials and allow efficient and safe in-vivo targeting for tumor cells. GENOPOIETIC applied for an international patent on this know-how.  LEADD BV has generated the novel anti-tumor agent Apoptin(r), which is specifically active in malignant cells, but not in normal cells. Therefore, the toxic effect of an Apoptin treatment might be relatively low. The fact that Apoptin induces a p53-independent and Bcl-2-stimulated type of apoptosis suggests that Apoptin-treatment is possible for various types of tumors, among those resistant to chemotherapy. LEADD holds international patents on this know-how.  In the past months (Exploratory Award: BIO4-CT97-9064) the plasmovirus vector expressing Apoptin was succ