RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Financial Markets and Regulation: A Genetic Programming Approach' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This project contributes to the understanding of the impact of financial regulation on securities markets through the development and application of an interdisciplinary approach which combines finance, economics and computer science to study order book and OTC markets. Our research supports regulators in forecasting and quantifying the effect of regulations.  The insights gained in this project are highly relevant for policy makers as European competitiveness and growth can be negatively affected if regulations are poorly designed.Despite a dearth of scientific insight into the effects of regulatory measures, short sale bans and financial transactions taxes to curb `speculation’ have strong political support in Europe. On the market design side, OTC markets, whose lack of transparency is believed to have deepened the financial crisis, are under scrutiny with the aim to centralise trade.We study microstructure models where investors and security traders submit orders or write contracts to adjust their asset holdings over time. Trader behaviour is represented by computer programmes which process information.  We identify behavioural equilibria through genetic programming which exerts evolutionary pressure to successively improve the traders' decision-making abilities until abnormal returns are eliminated. In these equilibria of behaviour and market dynamics, traders are optimally adapted to the institutional and regulatory setting.Results are obtained on the impact of regulatory measures on market stability (excess volatility and crashes), microstructure properties (market quality, price discovery) and the behaviour of investors and traders (asset allocation, skills) which are highly relevant to the understanding and prevention of market breakdowns and financial crises.T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advanced laser techniques to investigate C isotope discrimination during decomposition' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The ALICE project is aimed at acquiring two post-doctoral fellows with a research experience of less than 10 years to develop and apply an advanced laser spectroscopic methodology for laboratory and field investigations on isotopic fractionation effects associated to soil-atmosphere exchange processes. If C isotopic fractionation associated to photosynthesis and to dark respiration and photorespiration processes is quantified, our understanding of discrimination during decomposition is still poor.Current isotopic research on the C Cycle is based on the assumption that no discrimination occurs during respiration and decomposition processes. This hypothesis needs unambiguous testing. The research proposed is highly innovative not only for its scientific component but also for the methodological approach. In fact, the ALICE project is designed to convert the state-of-the-art spectroscopic technique into a deployable technology capable of providing accurate determinations of d13C-CO2 at atmospheric concentrations. Off-axis integrated cavity output spectroscopy will be implemented, using a room-temperature semiconductor diode laser at the unusual wavelength of 2.053 micron.In this spectral region, 12CO2 and 13CO2 molecules exhibit interesting absorption features, with optimum spectroscopic parameters for isotope ratio determinations. The use of a diode laser and a pair of small optical cavities enables to build a very compact device, suitable for field applications, satisfying, at the same time, the need of an extremely high detection sensitivity, as required to measure d13C in atmospheric CO2.Exploiting the high temporal resolution and the non-invasive nature of the analysis, the diode laser spectrometer will enable to design a number of laboratory and field experiments aim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The Physics of Galaxies 7 Gyr Ago'.

assistant: **Concept**

Over the past decade, redshiftsurveys and multi-wavelength imaging campaigns have drawn up anempirical picture of how many stars had formed in which types ofgalaxies over the history of the universe.  However, we have yet tounravel the individual pathways along which galaxies evolve, and thephysical processes that drive them.  Continuing with the previousapproach -- larger and deeper photometric samples -- is not adequateto achieve this goal.  A change of focus is required.In this ERC project I will embark on a new way to address the questionof galaxy evolution.  I will do so as Principle Investigator of therecently approved LEGA-C observing program that has been allocated 128nights of observation time over the next 4 years with ESO's flagshipfacility the Very Large Telescope.  This new survey will produce for2500 distant (at z~1) galaxies with, for the first time,sufficient resolution and S/N to measure ages and chemicalcompositions of their stellar populations as well as internal velocitydispersions and dynamical masses.  This will provide an entirely newphysical description of the galaxy population 7 Gyr ago, with which Iwill finally be able solve long-standing questions in galaxy formationthat were out of reach before: what is the star-formation history ofindividual galaxies, why and how is star-formation ``quenched'' inmany galaxies, and to what extent do galaxies grow subsequentlythrough merging afterward?LEGA-C is worldwide the largest spectroscopic survey of distantgalaxies to date, and ERC funding will be absolutely critical inharvesting this unparallelled database.  I am seeking to extend myresearch group to realize the scientific potential of this substantialinvestment (6.5M Eur) of observational resources by the Europeanastronomy community.  Timing of the ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Evaluating Practices And Validating Technologies In E-democracy And E-voting' (EVE) targeting Fifth Framework.

assistant: **Abstract**

The objective of EVE is to evaluate the impact of the ICT on the authorities and on the citizens by an international comparison of political uses.It should draw clear conclusions on the successes and limits of e-democracy, establish technological standards for business models and low cost, safe and efficient systems expected to be applicable at the local, national and European levels, by targeting these goals:- To identify synergies and complementarities between the various investigated initiatives in the European Union;- To study social and cultural reactions to the development of new services offered by digital cities and new voting systems in the European and the global context thanks to uses research and operations of benchmarking;- To provide consolidated input to standardisation and legal initiatives and to implement the appropriate dissemination actions.Work description:EVE is structured around 3 main streams of action, detailed in 6 operational workpackages and 1 management workpackage:1. Consolidate the base of knowledge This stream of action will deal with the evaluation of the existing experiments and implementations, not only in Europe but also on a global basis, and establish the corresponding documentary basis, with a regular update. It will assess the technological basis, the industrial environment and the foreseeable evolutions in order to identify the opportunities as well as the gaps.2. Coordinate, harmonise and optimise existing projects with EC support and co-ordinate with European and global practice. This stream of action will deal with the practical co-ordination and clustering of the existing IST supported projects, and will confront this practice with the global activities in the field of e-democracy and e-voting. It will evaluate the opportunit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A hoListic framework in the quality Labelled food supply chain systems' management towards enhanced data Integrity and verAcity, interoperability, traNsparenCy, and tracEability' (ALLIANCE).

assistant: **Innovation**

ALLIANCE represents a paradigm shift in the Food Supply Chain Systems’ management for the combat against Food Fraud, distinguishing from the traditionally approaches that leverage monolithic digitalized logistic solutions and standalone FSC interoperability protocols. ALLIANCE aims to provide a holistic framework that safeguards data integrity and veracity, enhances traceability and transparency and reinforces interoperability in quality labelled supply chain of organic, PDO, PGI, and GI food, through innovative technology solutions and validated approaches (such as distributed ledger technologies supported by IoT sensing devices, providing extensible anchors to interoperability protocols and use of in-situ portable rapid testing devices to detect adulteration and verify food origin and authenticity) and fosters evidence-based decision making through AI and ML for preventative interventions and actionable planning. The proposed framework will improve social and economic sustainability of quality labelled food supply chains by ensuring quality & authenticity, increasing food safety, while also considering climatic and environmental impacts of food products. The technologies to be employed in this project will be described and demonstrated in detail to reach higher technology readiness levels (TRLs) and enable smooth and rapid adoption by all stakeholders.


**Keywords:** treceability, authenticity, daata integrity, interoperability, food chain systems, quality label organic, PDO, PGI, GI food
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Innovation services and key account management support for Basque SMEs for 2020-2021', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

EU-28 SMEs made a significant contribution to the recovery and subsequent expansion of the EU-28 economy. They accounted for 47% of the total increase from 2008 to 2017 in the value added generated by the non-financial business sector, and for 52% of the cumulative increase in employment in the sector. In fact, their contribution exceeded what would have been expected on the basis of their relative importance in the economy.The internationalisation of SMEs is this year's special theme. SMEs can expand internationally in a number of different ways. Examples include exporting or importing goods and services, making outward foreign direct investment or attracting foreign investors to their business, becoming part of a national value chain which has an international focus, or being part of a global value chain, engaging in cross-border R&D and innovation collaboration, or licencing or franchising products or services.Thus, innovation management plays a key role at this respect and the Basque Country is not an exception at all. Programs supporting SME exports benefit directly only a sub-set of SMEs. However, indirectly, all SMEs benefit to someextent from growth in exports as higher exports raises a) overall income levels, and hence the demand for goods andservices sold by domestic demand facing SMEs, and b) the demand for goods and services originating from exporting-oriented enterprises. Some of the main drivers for a high competitiveness score can be linked to the presence of strong skillsand innovation capacity and capability, entrepreneurship and easy access to finance. In the Basque Country we are verymuch aware of this scenario and that is why the Basque Node has designed an implementation plan aiming at contributing tothe objectives of COSME. Facilitating access to E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Investigating similarity-breaking in galaxy clusters with XMM-Newton and Chandra'.

assistant: **Innovation**

If galaxy clusters, containing 80% dark matter, formed hierarchically under the influence of gravity alone, we would expect their intrinsic properties to follow self-similar scaling derived, assuming hydrostatic equilibrium, from basic viral relations. Such similarity applies equally to the hot X-ray emitting intra-cluster medium and thedark matter components. For instance, the total mass would be proportional to the X-ray temperature (M µ T³/²) and the X-ray luminosity would be proportional to the square of the X-ray temperature (Lx µ T²). While observations of the ICM have shown that there is an obvious similarity in the form of the gas temperature and density profiles, the scaling relations break down in the low mass limit. That real clusters do not follow the expected scaling laws points to the influence of non-gravitational processes during their formation. That the similarity breaking occurs in the low mass limit implies that here, the non-gravitational processes affect the properties of the ICM in direct competition with gravity. I propose to use high-quality XMM-Newton and Chancre data to attack the question of why galaxy clusters donor follow the expected scaling relations. Radial temperature, density, chemical abundance, mass and entropy profiles will be obtained for a large sample of clusters across a wide mass/temperature range. Such a sample will allow a global and integrated approach to testing the current theories of non-gravitational input presumed responsible for modifying the observed scaling properties. In particular, I will be able to test whether the dark matter component is collision or non-collision, and investigate he non-gravitational energy input through examination of the entropy and chemical abundance profiles. The project will make extensive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Mapping genetic suppression interaction networks in DNA break repair disorders'.

assistant: **Innovation**

DNA double-strand breaks (DSBs) occur frequently during a cell’s lifetime and constitute the most cytotoxic DNA lesion. DSBs compromise genetic integrity and have the potential to trigger cell death and generate pathological mutations. To counteract such threat, cells possess a complex protein network termed DSB response (DSBR) which senses, signals and repairs DSBs. Two predominant mechanisms repair DSBs: homologous recombination (HR) and non-homologous end joining (NHEJ). While loss of DSBR factors such as KU and XRCC4 (i.e. NHEJ proteins) or BRCA1 and BRCA2 (i.e. HR proteins) leads to early embryonic lethality and cell death, inactivating somatic mutations in these very same genes are associated with certain immunological and neurological disorders, premature ageing and cancer. This implies the existence of a suppressive (epi)genetic background that enables diseased cells to tolerate the otherwise lethal loss of essential DSBR factors.This project aims to systematically identify suppressor mutations which rescue viability upon loss of essential HR (BRCA1 and BRCA2) and NHEJ (KU80 and XRCC4) effectors. To reach such goal, I propose to (a.) genetically sensitize wild-type “healthy” mouse embryonic stem cells and B lymphoid cells by introducing mutations using a genome-wide CRISPR KO library. In such diversely sensitized background, I will then (b.) trigger the acute degradation of KU80, XRCC4, BRCA1 and BRCA2 proteins, using the auxin-inducible degron (AID) system. Suppressor mutations will be directly identified by sequencing sgRNA retrieved from survivor cells. (c.) The resulting suppression network maps will be integrated to clinical datasets to identify the relevance of these mutations in disease.Together, this project will unravel the DSBR protein networks that pe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The InDx CMC Implant. A new treatment for thumb base joint arthritis.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The InDx CMC Implant is for the treatment of thumb base joint arthritis. It is the first evidence-based, surgeon-led innovation, implant solution for this major clinical problem. The potential market is estimated at over €700M per year.The implant meets a major unmet clinical need for an ageing EU population. The implant re-creates the natural joint biomechanics to give a more reliable and clinically superior outcome for patients. This disruptive technology can change the treatment landscape for this condition. The implant provides an exciting new treatment option for an under-served population. It has been shown to eliminate pain and restore full joint mobility. The InDx Implant is smarter, safer, and simpler to insert than any current treatment options.The InDx Implant is patented, with a clear pathway to regulatory clearance in the EU and US. The company is led by a physician-innovator and is supported by medical device industry veterans and world-leading hand surgeons.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Brain remodeling during sexual differentiation and water to air transition in a hemimetabolous insect', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The evolution of the brain deeply transformed the animal kingdom leading to extraordinary animal diversity. Brain evolution and plasticity were necessary for many major evolutionary changes (e.g. terrestrialization of tetrapods, evolution of sociality) as well as developmental changes within an organism's life span (e.g. metamorphosis). In this project, I propose to study the brain remodeling in the mayfly Cloeon dipterum whose biology has the advantage of offering us multiple perspectives and insights on brain plasticity: (i) evolutionary perspective: mayflies are part of the insect lineage in which wings originated. This project will shed light on brain processes controlling wings and flight.(ii) developmental perspective: mayflies are hemimetabolous insects that present a gradual metamorphosis that nonetheless accompanies a major lifestyle transition from an aquatic juvenile form to an aerial winged adult.(iii) sexual dimorphism: the species C. dipterum displays significant sexual dimorphism as males have an extra pair of eyes (turbanate eyes), whose sensory signals need to be processed by the brain.Using a combination of single cell transcriptomics (sc-RNA-seq), in situ hybridisations and drug treatments, this project will yield a gene expression atlas of the brain of C. dipterum separately for both male and female individuals, across multiple points of its life cycle (two nymphal stages and two adult stages). This atlas will give us information on the brain processes necessary for the water to land evolutionary transition, those associated with flight and the acquisition of wings and those underlying the appearance of a new sensory organ - the turbanate eyes - in males, with the data conveniently navigable along annotated chromosomes. This study will also establish