RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Social media platform dedicated to rare diseases, using collective intelligence for the generation of awareness and advanced knowledge on this large group of diseases.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Share4Rare is a collective awareness platform of patients, caregivers, researchers and other stakeholders involved in the Healthcare of Rare Diseases (RD).  Based on a socially innovative approach, and building on citizen science and collective intelligence, we will engage and connect all the relevant stakeholders, towards the improvement of the quality of life, the management and the collection of scientific knowledge. The platform will be built around three important pillars: care, education and research. Our Collective Awareness Platform will take advantage of the high-motivated group of citizens (from patients to researchers, from volunteers to public health representatives and health professionals) linked or not to rare diseases, and their expertise. It will build on existing knowledge and initiatives, and will ensure a space for debate and co-creation, and a space for further research.  S4R will be based on the shared open data, and on the priorities set collectively. Collective intelligence from patients and families, democratic and transparent participation and a secure environment focused on three layers of interaction will ensure a platform to put in value citizen science that is needed to promote new research initiatives with a patient centred approach.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'AUTOMATED NMR STRUCTURE-BASED ASSIGNMENTS' (NMR-SBA) targeting Seventh Framework.

assistant: **Abstract**

While automation is revolutionizing many aspects of biology, the determination of three-dimensional protein structure remains a long, hard, and expensive task. Novel algorithms and computational methods in biomolecular NMR are necessary to apply modern techniques such as structure-based drug design on a much larger scale. The goal of this project is to address a key computational bottleneck in NMR structural biology, resonance assignments. We will accelerate protein NMR assignment by exploiting a priori structural information. By analogy, in X-ray crystallography, the molecular replacement (MR) technique allows solution of the crystallographic phase problem when a “close” or homologous structural model is known, thereby facilitating rapid structure determination. In contrast, a key bottleneck in NMR structural biology is the assignment problem. An automated procedure for rapidly determining NMR assignments given an homologous structure, will similarly accelerate structure determination. Moreover, even when the structure has already been determined by crystallography or computational homology modeling, NMR assignments are valuable because NMR can be used to probe protein-protein interactions and protein-ligand binding (e.g. via chemical shift mapping), and dynamics (via, e.g., nuclear spin relaxation). We will develop an MR-like approach for structure-based assignment of resonances and NOEs, to be applied when a homologous protein is known. The tool that we develop will accept both CH- and NH- RDCs, and 4-D NOESY data, and will implement a Bayesian scoring function for structure-based assignments. It will provide the user the option to use only NH RDCs or NH and CH RDCs and will be tested on real proteins. The source code will be released as open source with the user man
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Climate change, Environmental contaminants and Reproductive health'.

assistant: **Concept**

The research project investigates the possible impact of global climate change on reproductive health in one Arctic and two European populations. The key questions to be addressed are, firstly, how may climate change influence human exposure to widespread environmental contaminants and, secondly, how may contaminants impact occurrence of reproductive disorders as sensitive indicators of health? To provide affirmative answers to these questions the proposal will as a first step identify and describe mechanisms by which a changing climate may affect the exposure of Arctic and other human populations to contaminants through change in chemical use and emissions, delivery to the arctic ecosystem as well as processing within the arctic physical environment and human food chain. This work relies on modelling of existing data. Secondly, the project will expand the existing knowledge database on human exposure to polybrominated biphenylethers, perfluorinated surfactants and phthalates by analyses of 1000 biobanked serum samples collected in a EU FP5 project. Thirdly, the project will increase the limited knowledge on links between human exposure to contaminants and reproductive health. This work relies on a large existing parent-child-cohort, where a follow-up survey provide new data that are fed into risk assessment. Furthermore we will perform reviews of experimental and epidemiological literature to identify critical reproductive effects and exposure-response data for selected compounds as input to the risk assessment. Finally the project will integrate data on climate induced changes in contaminant mobility and distribution and links between contaminant exposure and reproductive health into a risk evaluation providing insight into possible future risk scenarios related to gl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Edged Crystalline Cohomology' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

This proposed project aims at opening new horizons in Grothendieck and Berthelot's theories of crystalline and rigid cohomology. These are p-adic cohomology theories that are used to study algebraic varieties in positive characteristic. In the last years, the subject has seen an incredible development. Recent important achievements have been, for example, Kedlaya's new proof of the Riemann Hypothesis in positive characteristic and Abe's construction of a p-adic Langlands correspondence for overconvergent F-isocrystals. On the other hand, there are still some fundamental open questions. The main weakness of the theory of rigid cohomology is the difficulty of performing classical geometric operations. For example, it is not known whether the direct image functors have all the desirable propreties (Berthelot's conjecture). This is mainly due to the fact that the definitions rely on differential forms, which need smoothness assumptions to be defined. The Applicant D'Addezio wants to use the edged crystalline site, a new site that he has recently constructed, to solve this issue. In particular, he wants to show that the edged crystalline site gives an alternative new definition of rigid cohomology and overconvergent isocrystals and then use this to prove Berthelot's conjecture. For this second step, he will exploit the fact that the definition of the edged crystalline site is completely algebraic. Other applications that will be developped include the construction of an integral structure for rigid cohomology and the construction of the category of F-isocrystals with log-decay for smooth varieties of arbitrary dimension (extending the results of Kramer--Miller).


**Keywords:** Crystalline cohomology, rigid cohomology, isocrystals, positive characteristic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PrOcess intensification and innovation in olefin ProducTIon by Multiscale Analysis and design' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

New manufacturing techniques such as 3D printing have the potential to drastically transform the chemical industry. Novel, complex, integrated reactor designs can now be created, that will allow to unlock alternative chemical routes, such as for methane activation. Driven by process intensification and the power of high performance computing, this project will enhance heat and mass transfer in advanced chemical reactors by multiscale modelling and experimentation. OPTIMA aims to:(1) develop in silico novel 3D reactor technologies and concepts with significantly improved selectivity and heat transfer by the use of additive manufacturing;(2) generate new fundamental understanding of kinetics, heat transfer and mass transfer by using advanced measuring techniques for processes of both current and future importance;(3) demonstrate the practical applicability of an open-source multiscale large eddy simulation (LES) platform in combination with finite rate chemistry for turbulent reacting flows;(4) transform the chemical industry by valorising methane and converting it to a platform molecule through oxidative coupling of methane.OPTIMA will focus on two olefin production processes of industrial and social importance in Europe, the exothermal oxidative coupling of methane and the endothermic steam cracking, demonstrating the universality of the proposed new paradigm. Starting from fundamental experiments and kinetic modelling (WP1), detailed chemistry will be implemented in an open-source LES multiscale modelling framework (WP2) generating in silico novel 3D reactor technologies with significantly improved selectivity (WP3). The power of the approach will be ultimately demonstrated in a novel, 3D integrated reactor, in which the studied exothermic and endothermic processes are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Comptability of calcarenites with other stony materials in sicilian monuments - the role of physical-chemical properties in deterioration', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The research project takes into consideration the Sicilian monuments built with calcarenites having different petrographic properties and laid with mortars of different nature. The aim of the project is: - to highlight, starting from the observation and the analysis of monument's deteriorations, the principal petrographic, physical and chemical parameters. These are linked to the nature of the stone, the mortars and the atmospheric conditions, and have been modified by the interfacing of different materials; - to perform measurements and experiments that permit the evaluation of: * the hydraulic balance of the solutions that circulate by evaporation and capillarity; * the modifications that are produced when calcarenites and mortars, of different nature come into contact; - to model the conditions of transfer and to determine the intervals in which the physical-chemical parameters may vary in order to assure the maximum compatibility between the different materials; - to determine the conditions according to which these results can be applied to guarantee a better restoration of the Sicilian monuments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Work on Demand: Contracting for Work in a Changing Economy' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Labour law as a scholarly discipline is widely believed to be in crisis. Since the time of its birth, both the nature of working relationships and the context within which they are formed and regulated have changed significantly. The difficulty for scholars is that old concepts don’t perform the function anymore of making sense of the field. Old arguments about the need to protect workers’ interests are met with counterarguments, informed by neoclassical economics, that protective measures inhibit economic growth and increase unemployment. The WorkOD project aspires to nothing less than a fundamental transformation of the discipline of labour law across the whole of Europe and beyond. Understanding the crisis to have at its heart a crisis of methodology, it aims to develop a new methodology for the study of the key legal concept of the contract for work. It aims to explain trends in the field of work organisation and working relationships and to assess the significance of particular labour market institutions to the achievement of policy goals in a way that is useful to scholars and policy-makers. And it aims to pave the way for future contributions by scholars to policy debates, so that they may influence in positive ways the identification of new economically and socially sustainable solutions to the problem of the division of responsibilities and risks between workers and those for whom they work. In a marked departure from the state of the art, the project defines contracting for work as an instance of economic, social and legal behaviour, influenced in a variety of ways by the institutional context within which it proceeds. Rejecting the reframing of labour law according to a full blown market paradigm, it argues instead for the utility of sociological methods. Its
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'INTERconnects enhanced by colloidal qDOT based optical amplifiers' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In the ERC project ULPICC, a new type of optical amplifier was invented that is much more compact than existing optical amplifiers based on rare earth doping and much cheaper to fabricate than the ones based on III-V semiconductors. It is based on our discovery that HgTe colloidal quantum dots (QDs) exhibit a gain threshold several orders of magnitude lower than any other type of QDs studied before.  Semiconductor QDs are fabricated using wet chemical synthesis procedures and can be deposited with cheap solution-based techniques such as printing which makes them competitive with traditional gain host media, with the additional advantage that the gain peak wavelength of colloidal QDs can be set freely by controlling the size of the QD, making them extremely versatile. An application (considered by big industrial players such as INTEL, IBM, NTT, …) particularly suffering from the lack of a compact optical amplifier is that of optical interconnects (OI) between chips to accommodate increasing data-transfer rates elusive for electronics. The OI market is expected to grow to $1 billion by 2021, where we expect the amplifier function can be valued anywhere up to 10% of the total OI value ! A heavily investigated approach to realize such an OI is that of ‘silicon photonics’, which has been shown to fulfil the requirements in terms of bandwidth and power consumption but lacks a native optical gain medium required to compensate the OI intrinsic losses. Therefore, the objective of INTERDOT is to assess the technical and commercial potential of optical amplifiers based on colloidal HgTe QDs, integrated on silicon photonics chips or in board-level OIs. We will validate their gain, specify their efficiency, initiate reliability and performance testing (through close industrial colla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Objectively Measuring MS Fatigue', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Multiple Sclerosis (MS) is the most common debilitating disease in young adults worldwide. Diagnosed in over 2.3 million people, this neuro-immunological disease is most prevalent in Europe and North America, with over 120,000 diagnosed cases in Germany alone. Great strides have been made in developing medications that slow disease progression, however, the daily symptomatology of MS remains largely untreated. This research proposes investigations of (1) an instrument for objectively measuring MS fatigue and (2) a therapeutic methodology for MS fatigue and disability. Despite great individual variation in MS symptomatology, “MS fatigue” verges on characteristic, reported by 80% of patients. However, there is currently no standardized means of evaluating or treating MS fatigue. Movement Behavior Analysis and Scales Test (i.e., BAST) tests and pre- and post-test vital signs of 40 persons with MS will be compared to that of 40 neurotypical matched controls. If the BAST is shown to reliably measure MS fatigue, then a testing and rating system for large-scale clinical use will be developed. To test the ability of the BAST to measure changes in MS fatigue and categorize physical disability, a long-term controlled study of the impact of hippotherapy (i.e., therapeutic horseback riding) will be undertaken in 24 individuals with MS. The standardized BAST will afford a robust analysis of movement ability and disability, enabling measurement of symptoms including gait, balance, spasticity, and fatigue. To achieve project objectives while facilitating ample mentorship, this project brings together the movement research facilities and faculty of the German Sport University Cologne (including mentor Dr. Hedda Lausberg, creator of the BAST), researchers and hippotherapists at the Gold
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'In Vivo Metabolite Modification in Hybrid Biological and Chemical Synthesis Systems'.

assistant: **Objectives**

This proposal aims to integrate the fields of synthetic biology and synthetic organic chemistry. This project aims to achieve this through the application of biocompatible chemistry: non-enzymatic reactions capable of modifying small molecules in the presence of a living system. The idea of using microbial metabolites as reagents for non-enzymatic transformations in the presence of the producing organism will greatly expand the range of organic molecules that can be accessed using natural and engineered living systems.We plan on applying a newly discovered engineered strain of E.coli that produces molecular hydrogen to important synthetic targets. We have demonstrated the use of this microbe in the presence of a palladium catalyst to hydrogenate a range of alkene- and alkyne-containing unnatural substrates. We propose to use this biocompatible hydrogenation reaction to the synthesis of industrially important advanced biofuels from biologically available starting materials. This would avoid the current need to extract the products of an engineered organism for further chemical manipulations, and would be the first example of the synthesis of these proposed molecules through purely biological means. Using bacterial olefin biosynthesis for the production of alkanes by interfacing single-/multi-system bacterial metabolism and a non-enzymatic, biocompatible hydrogenation reaction will represent an important advance in metabolic engineering and in biofuel manufacture.We then plan to develop a batch- or flow-reactor set-up in order to investigate the viability of advanced biofuel synthesis using an engineered microbe/non-enzymatic chemistry synthesis systems for the bulk production of these important target molecules.