RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Improving the services of the NMP NCP Network through Transnational Activities' in the context of a Horizon 2020 call.

assistant: **Objectives**

NMP TeAm 3 is the continuation of the successful EU projects NMP TeAm 1&2. It aims to facilitate transnational cooperation between NCPs within the Industrial leadership Part with a view to identifying and sharing good practices and raising the general standard of support by the NMP NCPs to programme applicants as described in the work programme. NMP TeAm 3 will achieve a consistent, improved and professionalised NCP service across Europe, thereby helping simplify access to Horizon 2020 calls, lowering the entry barriers for newcomers, and raising the average quality of proposals submitted. NNP TeAm 3:- Will create the mechanisms and tools for capacity building of NCPs' skills that will ensure the NCP Network's high and consistent level of services to clients. These will include  10 training events, 10 staff exchanges and twinning schemes and self -assessment through benchmarking.- Will provide the necessary tools to all NMP NCPs so that they can assist their clients to increase their success rate in H2020 and lower the barriers for participation for new applicants. These will include the improvement  of the Partner Search Facility of NMP TeAm 1&2, organisation of 4 brokerage events at large EU presidency conferences and 6 virtual information seminars for clients on H2020.- Will improve the outreach of the NMP NCP Network and maximise the impact of its activities, services and results to a wide audience of clients and stakeholders. This will be achieved through the continuation of the NMP TeAm website, which is already a focal point of the community of NCPs and programme applicants, continuous dissemination of information through social media and participation of NCPs at large NMP related events to provides assistance and services. NMP TeAm 3 will also maintain and creat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced MMICs for SOTM and satellites constellations' (2014-2020).

assistant: **Concept**

The proliferation of LEO (Low Earth Orbit) and MEO (Medium Earth Orbit) satellite constellations is changing the requirements needed by satellites and antennas in order to support the bandwidth and beam agility to accommodate the much more challenging tracking requirements uniquely associated with NGSO (non-geostationary orbit) operations. The development of beamforming techniques beyond today’s state-of-the-art is an important demand in the telecommunications industry. WIMMIC is currently developing a novel beamforming system for the ground antenna market. We now want, through SME Innovation Associate programme, to implement our expertise in this area to develop a beamformer to be implemented in telecommunication satellites. This is an important business innovation opportunity as there are no similar products in the market yet. For this, we need and IA expert in space qualified processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Structural determination and mechanistic understanding of membrane proteases', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Proteases are large group of proteins that cleave the amide bond in peptides and proteins. Common properties of all these proteases is the activation of water molecules for catalysis and that the proteins undergo conformational changes upon substrate binding.Hence it came as a surprise when membrane embedded proteases was identified. Proteases residing in the membrane should be able to create a microenvironment for water and the hydrophilic residues required for catalysis and should be capable of bending o r unwinding hydrophobic substrates making them suitable for cleavage.Membrane proteases have been implicated in different processes such as cellular differentiation, in unfolded protein response, lipid metabolism, signal peptide processing and, in prokaryotes, generation of peptide pheromones and response to extracellular stress.These have been collectively termed as Regulated Intramembrane Proteolysis (RIP), which has emerged as a novel mechanism in cell signalling. Some transmembrane proteins are kept inactive in their membrane-tethered form and require proteolysis for activation. Intramembrane proteolysis results in the release of these domains that move to a new location where they can carry out their biological function.Two of the well-studied membrane proteases include the rhomboid proteases involved in the Drosophila EGF receptor pathway and the g-secretase implicated in the processing of amyloid precursor protein (APP) implicated in Alzheimers disease. The membrane proteins belonging to this family have similar catalytic residues as some of the classical soluble proteases.This raises the question how these conserved amino acids embedded in the lipid bilayer have access to and activate water that is required for catalysis, and how the substrate is recruited. To
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Novel biological systems to study the role of single oncoproteins and tumour suppressors and their co-operation in leukaemogenesis'.

assistant: **Concept**

Human leukaemias are associated with identified genetic alterations including recurrent chromosomal translocations which lead to the synthesis of novel fusion proteins or to the ectopic or enhanced expression of normal proteins and deletion and point mutations which result in loss of function of tumour suppressor genes. Although considerable progress has been made in the identification of genes associated with specific leukaemias and the way their expression is altered, much less is know on how single genetic alterations contribute to leukaemic development and how dominant oncogenes and recessive tumour suppressor genes cooperate to generate the full leukaemic phenotype. We propose to use and further develop new cellular models to analyse how oncoproteins and tumour suppressors which are known to be involved in human leukaemias alter the proliferation, survival and differentiation control of primary hematopoietic progenitors in tissue culture. Fusion proteins involved in preleukaemic states like myeloid dysplastic syndromes (MDS), in chronic myelogenous leukaemia (CML) and in acute leukaemias of both the myeloid (AML) and lymphoid (ALL) lineage's will be considered. Specifically, we will analyse the properties of CMML-associated Tel-PDGFRbeta, of CML-associated BCR-ABL and of several oncoproteins associated with AML including PML-RARalpha, DEK-CAN, TLS-ERG as well as AML1 and MLL fusion proteins. Very few genetics alterations are known to be implicated in MDS. A major effort will be put in the identification of novel genetic lesions specific to MDS and in the study of the activity of the corresponding genes in hematopoietic progenitors. The cellular models we propose to use are also ideally suited to investigate how known tumour suppressor like p53 or candidate suppress
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Selective Alkylation of Complex Molecules in Flow' to be submitted under Horizon Europe.

assistant: **Abstract**

Developing new pharmaceutically-active molecules for the treatment of diseases that compromise the health and well-being of society is an essential but tedious process with rising costs, partially due to the arduous chemical synthesis of complex drug candidates. Recently, innovations in organic chemistry have streamlined the access to vast libraries of drugs by applying novel methodologies such as Late-Stage Functionalization of C-H bonds. However, one of the major challenges of editing biologically-active chemical structures is the development of processes that are compatible with diverse functional groups and functionalize one single position ""à la carte"" in an efficient and predictable manner.SELECTFLOW presents a multidisciplinary project that lies in the intersection of synthetic photoredox catalysis with microfluidic technologies, with the objective of delivering a selective, sustainable and predictable methodology for the modification of biologically-active molecules using light alkanes as raw materials. This will require the accomplishment of three specific objectives: 1) Development of a chemo- and regioselective synthetic methodology for the edition of nitrogen-containing aromatic heterocycles. 2) Translation of the developed photocatalytic system into a microflow-based setup, to enable the use of gaseous reagents in a milder and scalable fashion. 3) Understanding the mechanistic intricacies of the developed methodology in order to predict unexplored similar transformations. Overall, this proposal directly tackles one of the most important challenges for the pharmaceutical industry, the rapid and cost-effective production of innovative drugs, by delivering a sustainable valorisation of greenhouse gases, such as methane. It is expected that this innovative ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of liquid metal ion sources for cluster deposition of ferroma- gnetic materials and their application in a focussed ion beam system', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Liquid metal ion sources (LMIS) are point sources having a high angular intensity. Therefore, they are applied to focused ion beam (FIB) systems. The use of FIB systems using atomic ions is well known, but there has been very little work to date on focused clusters from LMIS. The investigation of clusters from ferromagnetic materials is of much interest for basic research as well as for applications in nanoscale magnetic devices and electronics and for new catalytic compounds. The project is concerned with the formation of clusters from ferromagnetic materials by LMIS, their deposition using a high energy ion optical column with ExB mass filter and the investigation of their physical properties. An attempt will also be made to form permanent magnetic microstructures using the high energy focused cluster beam.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'MODULAR DETECTION SYSTEM FOR SPECIAL NUCLEAR MATERIAL'.

assistant: **Concept**

The MODES_SNM project aims to carry out technical research in order to develop a prototype for a mobile, modular detection system for radioactive and Special Nuclear Materials (SNM). To maximize the detection capability for SNM the project will develop new detectors for fast and thermal neutrons, as well as gamma-rays, based on the technology of high pressure scintillation cells using noble gases (as 4-He and Xe) recently developed by ARKTIS. The proof-of-principle of the new detectors has already been recently demonstrated. The project’s goal is to deliver a tested prototype of a modular mobile system capable of passively detecting weak or shielded radioactive sources with accuracy higher than that of currently available systems. The identification of the gamma-ray emitter is also possible by using the spectroscopic analysis performed by high pressure Xe cells whereas the ratio between fast and thermal neutrons will bring information about the eventual shielding around the source. The R&D  aims at improve the current detectors  (i.e. at designing, constructing and testing robust, safe, and lightweight high pressure cells with an advanced read-out system) so that they can be used as basic components of the modular mobile system. A suitable Information System will be also developed to manage the detectors, integrate and analyze the data, and provide to the user simple information derived by a decision tree utilizing the data from the three types of detectors. The prototype detection system is the major deliverable of the project.  The project also includes the qualification of this detection system in laboratory condition to quantify its detection performance and ultimate limits, as well as a demonstration  phase in which the detection system will be field-tested by the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Functional Genomics and Ecological Impact of Viral Infection in the Toxic Haptophyte Prymnesium polylepis' (VINTPRYM).

assistant: **Concept**

Marine viruses are an active and important component of the microbial loop because they regulate microbial mortality, production, community structure, and biogeochemical cycling. They mediate genetic exchange between microbes, thus affecting the genetic diversity of microbial communities. Although marine viruses control blooms and shape the evolution of biodiversity in phytoplankton, little is known about the factors governing resistance and susceptibility of their hosts. Better understanding the host-virus interaction of marine phytoplankton is necessary to properly address its impact on phytoplankton dynamics, socio-economic activities, and medical applications.Over the past century, toxic blooms of Prymnesium have devastated increasingly aquaculture and native fish, shellfish, and mollusc populations worldwide. The toxic haptophyte Prymnesium polylepis produces toxins, which have haemolytic properties, that not only kill fish and other filter feeder but also co-existing plankton. Recently, the first virus of P. polylepis was found. The objectives of VINTPRYM are to investigate the interaction and co-evolution of Prymnesium polylepis and its virus and their diversity and population dynamics by field sampling. State-of-the-art RNA-Seq technology will be used to study the infection cycle of P. polylepis and its virus while classical bioassays will be used to measure the toxicity of the alga. Furthermore, environmental samples along the Norwegian coast will be taken to characterize the patterns of abundance and diversity of Prymnesium viruses by using metagenomic anlayses in comparison with PCR amplifications of the major capsid protein. Co-evolutionary aspects will be investigated by sequencing the viral genome and comparing it with the host genome, which is currently s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Role of the alpha4 integrin (CD49d) in Type-1 Diabetes mellitus prevention and treatment'.

assistant: **Objectives**

Type-1 Diabetes mellitus (T1D) is caused by destruction of insulin-producing tissues by autoreactive T lymphocytes, which leads to insulin deficiency. The high frequency of T1D, as well as the significant T1D-associated morbidity and the substantial burden from long-term sequelae despite state-of-the-art insulin substitution therapies underscore the urgency of developing causal treatments. Protection of remaining islet cell mass at T1D diagnosis and (potentially) subsequent islet cell regeneration could palliate or cure T1D and reduce long-term morbidity and mortality. The alpha-4 integrin is a dominant homing receptor for inflammatory lymphocytes, and blockade of alpha-4 adhesion is therapeutic in a variety of inflammatory conditions, including autoimmune diseases, in mice and humans. Thus continued substitution of anti-functional alpha-4 antibodies from birth could prevent T1D in the spontaneously diabetic NOD mouse. Such an approach is, however, not clinically applicable to patients, since the risk of T1D can not be predicted at birth. Therefore, we here propose to test the hypothesis that by ablation of alpha-4 integrin adhesion during pre-diabetes (normoglycemic insulitis) or during early diabetes (recent onset of hyperglycemia), the continued recruitment of autoreactive T-cells to inflamed pancreatic tissue might be arrested. It is proposed that this might protect the remaining insulin producing cells, and thus, depending on the regenerative capacity of the pancreatic islets, might prevent or delay T1D if initiated during pre-diabetes (secondary prevention) or cure or palliate T1D if initiated early after its onset (tertiary prevention). This hypothesis will be tested in a new genetic mouse model of inducible ablation of alpha-4 integrin in the NOD strain. Since h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Improving Mediterranean CYCLOnes Predictions in Seasonal forecasts with artificial intelligence' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Cyclones form frequently over the Mediterranean Sea. The most intense systems cause extensive damage in the region and beyond. The ability to make climate predictions several months in advance of such extreme events has a large number of crucial socio-economic applications for disaster risk reduction.State-of the-art Seasonal Prediction Systems exhibit a good skill in predicting anomalies in the seasonal mean of meteorological fields such as temperature and precipitation. The models’ ability to reproduce variations in the occurrence of extreme events tends to be however much lower. This is particularly true in regions such as the Mediterranean, where extreme events are often driven by small scale processes that are not well reproduced at the resolution at which SPS typically run.The use of artificial intelligence techniques such as machine learning in the study of climate has gained great traction in recent years. The power of those techniques lies in the ability to detect patterns in large datasets without having to make explicit statistical assumptions, allowing to build predictive model whose skill continuously improves as the volume of data on which the models are trained increases. One promising field of application is to use artificial intelligence to improve the prediction of extremes in climate models. In this setting a machine learning model is trained to find relationships between large-scale climate variables (for which dynamical models have a good predictive skill) and the occurrence of extremes.The aim of this project is to improve the predictability of intense Mediterranean cyclones combining advanced artificial intelligence techniques and a state-of-the-art dynamical seasonal prediction system. The project will not only contribute to the knowledge of clim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced Tools Towards cost-efficient decarbonisation of future reliable Energy SysTems' (ATTEST).

assistant: **Innovation**

The objective of the ATTEST project is to develop and operationalize a modular open source toolbox comprising a suite of innovative tools to support TSOs / DSOs operating, maintaining and planning the energy systems of 2030 and beyond in an optimised and coordinated manner, considering technical, economic and environmental aspects. The consortium, from six EU countries, that has been assembled to deliver ATTEST consists of five highly experienced research organisations in the energy systems area, two utilities that manage and operate the transmission system and the distribution system in Croatia, and two industry partners that specialise in the development of advanced ICT solutions and SCADA systems. The development of this broad spectrum of energy-related ICT tools and the utilization of next generation algorithms, demonstrated in a real world environment has not been attempted before. The outputs from the ATTEST project will enable accelerated dissemination, by a wide range of research institutions, within and outside of the project consortium, of the tools that will help TSOs and DSOs to better manage their networks. The demonstration of the results of the project will be valuable for the scientific community and EU energy industry and attest to the relevance of the solutions developed. The ATTEST’s ambition is to enable a wide range of users to utilize and test the tools developed in the project, thereby contributing to spread knowledge and experience in the energy systems community in the EU and on a global scale. This will contribute significantly to addressing not only the specific challenges of the call and the Horizon 2020 Energy Work Program, but also those of the EU’s Energy Union strategy and the 2020 Climate & Energy package.


**Keywords:** design, plannin