RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards Application specific tailoring of CarbOn nanoMAterials' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Impact of carbon nanomaterials (CNM) on society can be significant as they have the potential to revolutionize applications in sensors, catalysis, supercapacitors and energy storage. For sensors, currently used materials such as glassy carbon (GC), cannot selectively and sensitively detect neurotransmitters in physiological environment and the required surface properties in a given application environment are not known. However, by understanding the connection between sensing performance and material properties we can enable tailor-made materials. Unfortunately, even with the rigorously studied GC, this is not known. This can be attributed to the limited access to highly sensitive and high-resolution characterization methods and especially to the lack of in situ measurements. TACOMA-Project offers implementation of the world’s first in situ soft X-ray Spectroscopy (X-RS) setup with Stanford Linear Accelerator Laboratory and NASA based on the new transition edge sensor technology allowing detailed spectroscopic studies of carbon, its surface functional groups and various carbon-metal bonds under realistic use environments. Further, a novel hybrid characterization method combining photoelectron, absorption and X-ray emission spectroscopy to study CNM as fabricated, chemically modified and aged under laboratory conditions will be established. TACOMA is supported by a network of collaborators providing (i) access to machine learning and atomistic simulations that are integrated with the experimental work, (ii) insight into electrochemistry and (iii) access to high-resolution transmission electron microscopy. The TACOMA-Project will address questions such as what is the root cause of the electrocatalytic properties of CNM and how surface of the CNM evolves in the application
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of Reconstructed Electron Energy Loss techniques for Elemental Mapping in macromolecular structures' (REEL-EM) under Horizon Europe.

assistant: **Objectives**

A perfect macromolecular structure would provide an all-atom description of the molecule, including not only the well-ordered polypeptide or polynucleotide framework but all other species: metals and other ions, cofactors, lipids, substrates and inhibitors. However, current structural data include no or very little information on elemental composition, leading to significant errors and omissions in atomic models. To address this issue, I propose to develop a method, Reconstructed Electron Energy Loss - Elemental Mapping (REEL-EM), that will map elemental distribution within macromolecular complexes by bringing together well-established principles in analytical electron microscopy (EM) and biological cryogenic EM.Atomic-resolution elemental mapping in the electron microscope is well established for dose-tolerant samples. Electron Energy Loss (EEL) techniques capture information from inelastic scattering events in the sample, and energy losses are characteristic of the element and chemical state of the scattering atom. These techniques require a high electron dose to achieve useable signal-to-noise ratio, severely limiting their application to biological samples.Our novel approach combines the image processing tools of single-particle cryo-EM with EEL techniques, allowing us to add EEL signal in the 3D particle space, effectively dividing the dose required for sensitive elemental analysis between many images. Preliminary work in my research group confirms that our proposed approach is valid - we are able to generate maps of specific elements in the 3D particle space. I propose to extend this early work to achieve single-atom detection at 1-nm spatial resolution in the course of this five-year project. Our work will characterise and optimise all aspects of data collection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Portable Real Time Detection of Airborne Asbestos Fibres for Tradespersons' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Asbestos-related diseases are the leading cause of occupational death in Europe. 500,000 European workers, mostly within the construction, demolition and remediation industries, are expected to die by 2030. Despite a ban on asbestos use, our members’ workers are continually exposed to this potent, invisible carcinogen from legacy products such as insulation, water tanks, ceiling panels, floor tiles and textured wall coverings. We feel that this level of risk is completely unacceptable for our members and must be addressed. Currently, asbestos is detected by a slow process of air sampling, with samples sent off to a lab and results being returned days later. Not only is this too late to take action, but tests are only performed if asbestos is suspected to be present. There is currently no way to detect asbestos in real-time. The ALERT project will change this. A decade ago, researchers discovered a way to detect asbestos fibres through a light-scattering technique. This work stalled due to technical and cost barriers; barriers we now believe we can overcome. We have assembled a world-leading consortium to extend this early research and develop a low-cost portable detector that can be worn by the worker to continuously monitor their work environment. By developing the ALERT system, we will provide 30 million European workers with a means of detecting asbestos the moment it is disturbed, allowing them to protect themselves and avoid becoming one of the 100,000 people worldwide killed each year by exposure to asbestos.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Scalable Semantic Product Data Stream Management for Collaboration and Decision Making in Engineering' (2007-2013).

assistant: **Innovation**

The goal of SMART VORTEX is to provide a technological infrastructure consisting of a comprehensive suite of interoperable tools, services, and methods for intelligent management and analysis of massive data streams to achieve better collaboration and decision making in large-scale collaborative projects concerning industrial innovation engineering.<br/>SMART VORTEX captures the tractable product data streams in the product lifecycle of design and engineering. In each phase of this lifecycle, different streams of product data are generated. Amongst other, these product data streams contain streams from sensors (data rates of Gigabytes per second), simulation, experimental, and testing data (millions of complex data sets), design data (complex and exchanged between different domains), multi-media collaboration data (heterogeneous, and high information density), and higher level inferred events generated by analyses.  These data streams are produced and consumed in all phases of the product lifecycle. The large volume of data in these streams makes the detection of pertinent information a hard problem for both technological infrastructures and humans. SMART VORTEX uses a Data Stream Management for managing, searching, annotating, analysing and performing feature extraction on these data streams.<br/>Within the lifecycle of design and engineering projects a large number of people need to collaborate in order to achieve the individual project goals, such as bringing the next generation flat panel TV to the market before the competition does, identifying opportunities for improvements of existing products, or the maintenance of products in use. These projects are basically large distributed collaborative processes, where people from different domains of expertise and differe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'REMOTE MICROSCOPY, NANOSCOPY AND PICOSCOPY BY HYPERSPECTRAL LIDAR' under Horizon Europe.

assistant: **Concept**

HyperSense will spearhead hyperspectral lidars expanded to exotic spectral regions outside the imaginable by lidar community, and demonstrate stand-off biosensing beyond what can be resolved by existing methods by employing plasma and supercontinuum light sources. Leveraging my patented hyperspectral Scheimpflug lidar concept, adding an uncontested number of spectral bands, spatio-temporal resolution and sensitivity, We will reveal aspects of our biosphere inaccessible by existing lidars. Active remote sensing of our biosphere uncovers details that cannot be resolved in space and time by sunlight, e.g. protein absorbance shielded by the ozone layer, life in dark ocean depths, narrow oxygen lines in a breath or nocturnal movements of disease vectors. Lidar constitute an efficient measurement technique where the same light transilluminates a volume until it interacts with the sample and simultaneously reports range and backscatter quantitatively, whereas hyperspectral lidar also provide microscopic absorption pathlengths, nano-features on biological surfaces, and deformations of electron shells on the picometer scale.HyperSense will explode multiple boundaries of current lidar, demonstrate and revolutionize biomonitoring, by my inexpensive, robust, compact and portable Scheimpflug method. HyperSense comprise 4 novel hyperspectral lidars with short, long, narrow and broad spectral coverage, applied to 8 biological challenges, showcasing light-biology interactions on the micro, nano and picoscopic level:A) DUV lidar (220-440 nm) Biomolecules specificity for classification of pollen and lichenB) Aquatic lidar (400-800 nm) Profile plankton biodiversity using both oscillatory and spectral propertiesC) Hires NIR lidar (760-762 nm) Resolving O2 and temperature in breath to under
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The developpent of corrosion-resistant alloy spray coatings' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The working life of a variety of large machine components can be extended by the use of alloy spray coating technology. This is applied in two main ways; Fabrication of parts to smaller specification than required, then application of alloy coating to give higher materials performance at surface compared with the bulk material Rebuilding of worn surfaces on used parts to original specification The composition of the spray alloy is adjusted to give the desired combination of wear and corrosion resistance. For alloy materiais. these properties are to some extent mutually exclusive. In most engineering applications, wear resistance is required over corrosion resistance, and the spray alloys are optimised for this property. However. for the food and chemical process industries, an equivalent stress is placed upon corrosion resistance, Spray alloys developed for these applications therefore represent a compromise of wear and corrosion resistance, with limited performance for both materials properties. There is therefore a need for innovative materials research and development to widen the number of alloy composition variables in order to allow maximum performance in both wear and corrosion resistance. This project will specify optimal compositions of Ni/Cr spray coating alloys for use in a number of representative end user applications. The central aim will be to increase the working life in terms of both wear and corrosion resistance, but at reasonab!e cost. It will also be necessary to develop the spray fusing techniques already in common use for the application of the new alloy compositions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Smart interrogation of the immune synapse by nano-patterned and soft 3D substrates' (SYNINTER).

assistant: **Innovation**

We aim to design smart substrates and suitable detection techniques to understand better the dynamics and spatial organization found in the immunological synapse, with the ultimate goal of developing new diagnostic tools for sensitive detection of immune deficiency diseases that arise from faulty adhesion. The immunological synapse (IS), formed at the interface between a T-lymphocyte and an antigen presenting cell, has been the target of intense multidisciplinary research in the last decade. Studies point to a crucial role for adhesion mediated by protein clusters for the stability and activity of the synapse. However, even the cluster size - micro or nano scale - remains contentious. Furthermore, while in vivo, the synapse is formed in a soft 3D environment, most in vitro experiments are on hard 2D surfaces. Clearly, one way to probe how the micro/nano environment of the T-cell influences the IS is by interrogating it with artificial substrates that are soft, three dimensionally structured and exhibit motifs down to the cluster length-scale. We shall develop 3D and soft polymeric structures with controlled placement of adhesion molecules and antigens on a single molecule level. The structure, assembly and signalling for stable as well as dynamic IS, on such substrates, will be investigated. Mechano-transduction at IS will be probed by using soft substrates of tunable Youngs modulus. Advanced optical techniques will be developed for quantitative and dynamic mapping of proteins and the cell-cell interface topography. Quantitative reflection interference contrast microscopy, will permit characterization of adhesion of native cells without the need of a special labelling strategy. Our advanced substrates and observation techniques will open up new ways to probe inter-cellu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'HBV GenetIc and Proteomic Screen' in the context of a Horizon 2020 call.

assistant: **Objectives**

Hepatitis B virus (HBV) is a major global health problem resulting in progressive liver disease, including cirrhosis and hepatocellular carcinoma – the second leading cause of cancer death worldwide. Although HBV structure and genome have been characterized, key aspects of the viral life cycle remain poorly understood because of the lack of a robust HBV infectious tissue culture system. Moreover, despite the development of a safe and efficient vaccine, over 240 million people are chronically infected with HBV. Thus, the development of efficient anti-viral strategies to cure HBV infection remains a critical unmet medical need. To date, there is an important gap of knowledge in basic HBV biology that results in the lack of identified drug targets to cure chronic HBV infection. These limitations can now be overcome using a state-of-the-art HBV tissue culture model combined with technological advances in genetics and proteomics. The aim of HIPShot (Hbv genetIc and Proteomic Screen) is to use cutting-edge screening techniques in human cells to identify host factors that are essential for HBV infection and at the same time targets for antiviral cure. With my expertise in using forward genetic screening and proteomic approaches, I decided to join one of the leading groups in HBV research, lead by Prof. Thomas Baumert (TB) and based at Inserm Unit U1110 of Université de Strasbourg (UdS), to exploit novel technologies in the investigation of host-virus interaction. The proposed project will provide unmatched insights into the basic biology of HBV infection by shedding new light on cellular host factors exploited by HBV to replicate and persist in human cells. These identified host factors will constitute direct drug targets with an important therapeutic potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'A SYSTEMATIC APPROACH TO SAVE ENERGY IN SWIMMING POOLS'.

assistant: **Innovation**

Save 60% of primary energy through careful combination of conventional and innovative technologies, including integrated solar preheating of ventilation air, CHP, innovative lighting, etc.The technologies committed have been carried out successfully.The innovative part of the project is:- Preheating of ventilation air with solar air collectors integrated in the building structure;- Heat recovery with a cross-flow heat exchanger for the basic load in the swimming pools supplementing the air collector;- Filter system with low pressure drop and a high efficiency for the purification of pool water;- Lighting of the swimming pools (under water) with a light-guide system and high efficiency lamps (market introduction)- Joining and optimisation of innovative and standard energy saving technologies by an energy management system. This is a necessary part of the total system to reach the calculated savings;- Re-use of waste water from the swimming pools for flushing toilets and cleaning;- Heat recovery from waste water;- Reduction of the pressure drop in piping and fixtures;- Closing of the water slide after closing hours;- Electronic regulation of fans instead of re-circulation of ventilation air;- Controlling of the air volume for ventilation depending on the chlorine content;- Co-generation of heat and power for the full heating load by using the heat storage capacity of the pools and supplying the public grid with the superfluous electricity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The blood monocyte as a tool for the prediction of type 1 diabetes' to be submitted under Fifth Framework.

assistant: **Abstract**

Europe has one of the highest prevalence of insulin dependant diabetes (IDDM), with more than one million patients. Treatment modalities are far from optimal, and chronic IDDM has devasting vascular complications with staggering costs for the Community. Six European groups and a research-based biotechnology firm with expertises in the field diabetology and immunology, here together design a novel approach to develop new clinically applicable tools to predict IDDM development. These tools are based on the new insight that monocyte-derived cells play key roles in the aetiology and pathogenesis of IDDM. Major effort will be directed towards DNA micro-array methods for discovering molecules in monocytes specific for the prediabetic state. From this, monocyte-related tests for the prediction of IDDM wil are created. The (pre-) diabetes specific molecules will also have great potential as basis for novel therapies in the prevention of IDDM.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New Molecules of the pentraxin superfamily as markers and regulators of disease.' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The pentraxin group of proteins includes acute phase reactants and is synthesised by cytokine stimulated cells; pentraxin possess pentameric structure (hence the name) and lectin-like three dimensional structure. The best known representatives of this family are C-reactive protein and serum amyloid component. Both of them are produced by IL-6 induced hepatocytes. CRP plays a time honored role as marker of inflammation infection organ damage and according to recent data impending ischemic heart disease. The APR biological function is still undefined, but presumably of relevance if one consider that these proteins are very well conceived in evolution from hose-shoe crab to humans. Recent work has lead to identify a new family of pentraxin related proteins which have been termed long pentraxins" and are produced chiefly by endothelial cells in response to inflammatory mediators such as IBETA but not to IL-6. The prototype molecule of this group PIX 3 has been isolated and characterised by the joint effort of a few European research groups (Brevario et al J. Biol. Chem 1992.) The board objectives of the present project is to explore the feasibility of a collaborative European work aimed to better defining the exploitation of nex pentraxin as diagnostic and therapeutic tools."