RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Digital Signal Processing in Audiology', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The rapid advance in embedded digital signal processing technology has recently led to significantly enhanced hearing devices. Besides the very basic task of restoring loudness, modern hearing aids and cochlear implants feature a range of advanced processing capabilities such as beamforming microphone arrays, noise reduction and automatic controls. While some of these features have already resulted in improved performance, advanced approaches to signal enhancement, to auditory scene analysis and to signal reproduction strategies promise much improved user benefits. The application of advanced signal processing schemes in hearing instruments for the improved rehabilitation of hearing impaired users, however, requires close collaboration of researchers in digital signal processing, audiology and psychoacoustics.  The ITN AUDIS will perform research and training in digital signal processing for applications in hearing instruments. The unique approach lies in the research and development of advanced statistical signal processing algorithms in the interdisciplinary area of audiology. This network thus reacts to the strong demand of hearing aid and cochlear implant companies for highly qualified researchers who are proficient in both the advanced signal processing methodologies and their application in the context of hearing instruments, and who are thoroughly familiar with user requirements in this domain. This network consists of 4 university and 2 industrial partners and associated partners. A key characteristic of this network is that all partners have substantial experience in interdisciplinary work and can thus provide exciting research opportunities to network fellows.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enhancing the conversion of 'power to ethylene' through developing surface oriented catalysts' (PEEC).

assistant: **Concept**

Ethylene, as a key building block in the chemical industry, has large market demand. Currently, the dominant production route is steam cracking of ethane, which is a highly endothermic and carbon intensive process. Proton ceramic electrochemical cells (PCECs) can selectively remove hydrogen from the reaction system, thus breaking the thermodynamic equilibrium limitation. In this project, the improved PCECs equipped with high-performance anodes catalysts will be used as environmental-friendly, efficient, and reliable way to co-produce ethylene and hydrogen from ethane at low temperature (400-550 C), demonstrating ethane conversion not less than 50% and ethylene selectivity not less than 80%. Here, we will combine hydrothermal synthesis and in-situ grown nanoparticles from matrix crystal lattice to develop the nanocatalyst with the specific surface facet and meta-oxide interface. The research tasks will be distributed into 6 work packages (WPs).  In WP1, We will use hydrothermal synthesis to prepare nanocatalysts with specific surface orientation and in-situ growth of metal nanoparticles from the pre-doped matrix crystal lattice to form a special anchored interface structure, improving the stability and efficiency of the catalysts. In WP2, we will integrate the well-defined catalysts into the halfcells with the BaCe0.7Zr0.1Y0.1Yb0.1O3 anode backbone through infiltration. In WP3, the ethane conversion and ethylene selectivity of the PCEC will be characterized by gas chromatography supported with electrochemical characterizations. In WP4, DFT calculations in combination with surface characterization will be conducted to explore the reaction mechanism of ethane dehydrogenation at the anode. In WP5, we will cooperate with other laboratories for discussion and advice. In WP6,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Hhat inhibition as a novel approach for selective cancer treatment', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Being the first or second most common cause of premature death in over 100 countries, cancer imposes a major burden on modern societies worldwide. Inhibition of the Hedgehog pathway has had success, both in vitro and in the clinic, but resistance is a commonly encountered problem, making alternative Hedgehog modulators in high demand. Hhat is a membrane associated O-acyl transferase (MBOAT) whose only known function is the palmitoylation of Hedgehog, a posttranslational modification crucial for Hedgehog signalling. Targeting Hhat thus represents a uniquely specific way to target the hedgehog pathway that could be less prone to gaining resistance, but research in this area is hampered by a lack of good tool compounds. Here I propose to use cutting edge chemical biology tools to develop selective high potency Hhat inhibitors with thoroughly validated cellular activity. Such inhibitors are crucially needed to validate Hhat as a target in cancer therapy and the methodologies developed could be transferred to target other clinically relevant MBOATs in for example the Wnt pathway.


**Keywords:** Hedgehog, Organic synthesis, Parallel synthesis, Chemical proteomics, Photo-affinity ligation, Cancer, biology, Cellular target engagement
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The biological role of tandem repeats as hypervariable modules in genomes'.

assistant: **Innovation**

Living organisms change and evolve because of mutations in their DNA. Recent findings suggest that some DNA sequences are hypervariable and evolvable , while others are extremely robust and remain constant over evolutionary timescales. The long-term goal of our research is to combine theory and experiments to investigate the molecular mechanisms underlying genetic robustness and evolvability. Apart from the fundamental aspects, we also plan to explore practical facets, including swift evolution of pathogens and construction of hypervariable modules for synthetic biology. In this proposal we focus on one specific topic, namely the role of tandem repeats as hypervariable modules in genomes. Tandem repeats are short DNA sequences that are repeated head-to-tail. Such repeats have traditionally been considered as non-functional junk DNA and they are therefore mostly ignored. However, our ongoing research shows that tandem repeats often occur in coding and regulatory sequences. The repeats show mutation rates that are 10 to 10.000 fold higher than mutation rates in the rest of the genome. These frequent mutations alter the function and/or expression of genes, allowing organisms to swiftly adapt to novel environments. Hence, repeats may be a common mechanism for organisms to generate potentially beneficial variability in certain regions of the genome, while keeping other regions stable and robust (Rando and Verstrepen, Cell 128: 655; Verstrepen et al., Nature Genetics 37: 986; Verstrepen et al., Nature Microbiol. 2: 15). We propose a multidisciplinary systems approach to unravel the biological role of repeats. First, we will use bioinformatics to screen various model genomes and identify, categorize and analyze all tandem repeat loci in the model eukaryote Saccharomyces cerevi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'SUPERSTAR FIRMS IN THE GLOBAL ECONOMY'.

assistant: **Concept**

The study of international trade has made huge advances in recent decades by moving away from a perfectly competitive view of the world, and allowing for increasing returns and product diversity. However, in this effort it has borrowed very selectively from the theory of industrial organization. Both the “new trade theory revolution” of Krugman and others, and the more recent development of models with firm heterogeneity by Melitz and others, have entrenched the position of monopolistic competition as the dominant approach to modelling international trade. This ignores the insights of oligopoly theory, since it assumes that all firms are infinitesimal in scale, are equally likely to exit in a given period, and do not interact strategically. It also sits uneasily with a growing body of empirical work which shows that much of international trade is accounted for by very large firms.My project aims to bridge this gap by extending the theory of oligopoly and trade. Drawing on my past work, I propose to develop a new theoretical framework which recognizes the central role played by “superstar firms” while also allowing for entry of new firms and for interactions between sectors in general equilibrium. This involves three distinct strands. First is the development of models with a small number of large firms, interacting strategically with each other, while simultaneously competing against a “monopolistically competitive fringe” of small firms. Second is the application of these models to allow for a broader range of behaviour by large firms, including strategic investment in research and development, and a proliferation of products produced and markets served. And third is to use the techniques of monotone comparative statics to explore the properties of superstar-firm model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Monitoring and controlling volatile organic compound (VOC) emissions  by using novel on-line FTIR/iPAS technology', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Strict limits have been set for volatile organic compounds (VOC) emissions due to their direct and indirect effects on the environment and the potential risk to human health. Industrial plants using solvents have to limit their emissions to the levels stated in VOC-directive (Directive 99/13/EC) before the end of October 2007, whereby VOC emissions from the solvent using industry should be reduced by 67% compared to the 1990 VOC levels. Furthermore the directive sets very strict limits (in some cases below 1 ppm) for the so called ”R-labeled” VOCs, which contain for example different chlorinated VOCs.  In environmental analysis, one of the most challenging and still unresolved needs is the reliable measurement of (VOC). VOC emissions are normally present as mixtures. Furthermore, it is typical for many really harmful VOCs to be present at low concentrations. The emission limits for these compounds are also very low. This poses an enormous challenge in terms of the sampling, measurement and the selection of removal methods. To date, however, no reliable, selective and sensitive measurement technique exists that is capable of identifying the VOC emission levels of certain “R-labelled” VOCs in order to fulfil the limits stipulated by new directives.   This project will develop an affordable, reliable tool for on-line monitoring of harmful and toxic VOC emissions. The main focus will be the development of a novel iPAS sampling technique and calibration for online process measurements, which will be applied for its use in several demanding gas measurements (VOC emissions), where the use of traditional measurement techniques have clearly failed, or have proven very difficult and laborious. As a result, reliable emission measurement would form a coherent basis for the developm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Volatile evolution on terrestrial planets' (Kryptonis) under Horizon Europe.

assistant: **Objectives**

Volatile elements, such as water, carbon and nitrogen, with low condensation temperatures, are needed to achieve and sustain habitable conditions. They also regulate planets geodynamics and climate evolution. However, how these volatiles were delivered to terrestrial planets and how they subsequently evolved is actively debated. Due to their inertness and high volatility, the noble gases krypton and xenon are unique geochemical tracers of volatiles. Their non-radiogenic isotopes have kept the signatures of the sources that delivered volatiles to planets and of the evolutionary processes subsequent to accretion, like recycling via subduction. Yet the non-radiogenic krypton and xenon isotopes have barely been used, in particular for krypton, due to major analytical challenges.Here, I propose to develop an original geochemical tool, the non-radiogenic krypton and xenon isotopes. I will develop innovative analytical protocols to allow high precision measurements of these isotopes. The objectives are to determine the source(s) of volatiles for terrestrial planets and to assess when volatiles started being recycled into the Earths mantle via subduction. To achieve these goals, I will (i) determine the precise krypton and xenon compositions of different types of meteorites to evaluate whether one meteorite type can explain the signature of the Earths and Mars mantles, (ii) assess the volatile source(s) of the Martian mantle by studying the krypton and xenon compositions of the Martian meteorites shergottites and nakhlites, (iii) determine the krypton and xenon compositions of different Earths mantle sources, from the present-day to the Archean, by analyzing mid-ocean ridge basalts and granitoids. The analyses on granitoids will be combined with high-pressure high-temperature e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Reprogramming of IELs at the intestinal epithelial barrier during virus infection' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Intestinal epithelial resident CD8+ T lymphocytes, such as intraepithelial lymphocytes (IELs), are located at epithelial barriers. They play a key role in tissue protection by promoting the elimination of infected cells, while producing antimicrobial factors and epithelial growth factor. Due to the positioning of IELs underneath the single epithelial layer and their potential involvement in modulating intestinal pathology, the activation status of IELs is intensively studied. Viruses modify CD8 T cells in many ways. Murine cytomegalovirus (MCMV) belongs to β-herpesviruses and is often used as an animal model to study the pathogenesis of human cytomegalovirus (HCMV). MCMV specific resident memory CD8 T cells has been described in intestine. Memory CD8 T-cell in the gut epithelium induced by persistent viruses such as MCMV has a distinct quality from both conventional memory and “inflationary” memory CD8 T cells, which may be relevant to protection against mucosal infections. The outcome for patients with HCMV reactivation appears worse than for patients without reactivation. It is not absolutely clear whether HCMV is a contributor or a bystander cause of inflammatory bowel disease (IBD). In this proposal we aim to define the possible mechanisms  by which virus impact  IELs at the intestinal epithelial barrier  in comparison to virus impact on circulating CD8 , and how they then behave in different challenges to which intestine could be exposed such as DSS triggered colitis, antibiotic treatment and high fat diet. For this, we will use sequencing approaches and data analysis of gene in different conditions in IELs. How the IELs “reprogram” their gene composition due to combination of the challenges will be our main goal additionally to classical approaches to with the imm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'GREEN ADVANCED HIGH ENERGY PROPELLANTS FOR LAUNCHERS' (GRAIL) targeting Horizon 2020.

assistant: **Abstract**

Solid rocket motors are today the most cost effective, competitive and reliable propulsion technology for space launch systems. State of the art solid rocket propellants are based on the oxidizer ammonium perchlorate, AP, and aluminium powder, embedded in a polymer binder matrix. Unfortunately, AP has a negative impact on the environment and on personal health due to ozone depletion, thyroid gland interference and acid rain formation.The objective of the GRAIL project is to determine if it is possible to replace AP by using a mixture of the new green high energy density oxidizer ammonium dinitramide, ADN, and the low cost oxidizer ammonium nitrate, AN. A high energy density green solid propellant will be developed and compared with state of the art solid propellants with respect to safety, performance and cost, to determine if replacing AP with ADN/AN is a feasible option. The results will serve as important input for decision makers when considering development of future European launch systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SUStainable production of High Entropy Alloys from Secondary metals' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Sustainable Production of High Entropy Alloys from Secondary Metals (SUSHEAS) emerges as a beacon of innovation, targeting the sustainable and efficient production of chemically complex multicomponent High Entropy Alloys (HEAs) through the use of secondary metals. This initiative is set against the backdrop of the current state-of-the-art, where HEA production predominantly relies on virgin materials, which not only contribute to significantly negative environmental impacts but also entail high energy consumption and financial costs. Positioned at the innovation forefront, SUSHEAS introduces a sustainable approach to HEAs production, underpinned by a collaborative framework that unites academic and industrial expertise. Through strategic staff exchanges, the project promotes a dynamic knowledge and skill transfer, enhancing the consortium's innovation and research capabilities. This collaboration accelerates the adoption of eco-friendly HEA production methods and fosters a learning culture. SUSHEAS's focus on AI- driven optimization, alongside techniques for metal recovery, manufacturing, characterization, and prototype demonstration, sets new collaborative research standards in HEA production. By directly tackling environmental, sustainability, and resource efficiency challenges, SUSHEAS demonstrates the power of collaborative innovation in overcoming the complexities of producing HEAs from scraps, marking a significant step towards the advancement of science and technologies in sustainable HEA production. It also highlights the anticipated widespread use of HEAs in future applications that require advanced materials, underlining the importance of defining and popularizing sustainable production methods for HEAs right from the start.


**Keywords:** High Entropy Alloys
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Joint ECO-City developments in Scandinavia and Spain' under Sixth Framework.

assistant: **Concept**

The scientific and technological objectives of the ECO-City development project are to establish a basis for and demonstrate innovative integrated energy concepts in the supply and demand side in three successful Communities in Spain, Denmark/Sweden and Norway. The three Communities all have an advanced energy profile in comparison to other national neighbouring communities. The demonstration activities, which are coordinated with the Communities on-going activities, are based on both the demand (Eco-build/RUE) and the supply of (RES).All demonstrations will be designed using a Whole Community Design Approach" in order to ensure the largest energy saving potential possible, and to ensure coherence and end-user involvement in all the activities. The impact of the Swedish/Danish community actions (2000 household equiv. energy cons.):30% reduction in energy demand,100% supply of heat from biomass,100% supply of electricity from wind power,100% waste recycled and recovered for CHP production."