RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Gene therapy for mucopolysaccharidosis - adeno-associated virus and lentivirus as vectors for muscle, liver, central nervous system and bone marrow' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content The goal of this project is to permanently correct beta-glucuronidase deficiency in the mucopolysaccharidosis type VII (MPS) mouse model. For this purpose, we will perform gene transfer experiments in several tissues affected by this lysosomal storage disease such as liver, skeletal muscle, central nervous system and bone marrow cells using adeno-associated virus and lentivirus as gene transfer vectors. These vectors have been proven to be efficient for gene transfer in muscle (adeno-associated virus), central nervous system and bone marrow cells (lentivirus). An alternative approach that will be tested is a cell-encapsuladon method where the cells, permanently transfected with AAVs or retroviruses, will be protected against the host immune system by a permselective membrane and then, implanted into the target tissue. The efficiency of these gene transfer systems in the MPS mouse model will be analyzed by specific enzyme staining as well as phenotypic correction of storage lesions at short and long term. Training content (objective, benefit and expected impact) The training objective of this project is to test alternative gene transfer strategies to improve gene therapy for mucopolysaccharidosis. The applicant will be able to learn new gene transfer techniques and the impact of this research will be very significant for treating MPS patients in the future. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Transcriptional control of plasma cell development and function' in the context of a Horizon 2020 call.

assistant: **Objectives**

Antibody-secreting cells consisting of short-lived proliferating plasmablasts and long-lived quiescent plasma cells are essential for the acute response to infection and long-term protection of the host against pathogens. Only a few regulators (Blimp1, IRF4, XBP1, Aiolos, Ikaros and E-proteins) have been implicated in the transcriptional control of antibody-secreting cells, and their target genes, with the exception of Blimp1 and E-proteins, are still unknown. This proposal aims to systematically identify key players in the development and function of antibody-secreting cells by using the CRISPR/Cas9 and Cre/loxP methods.     For this, we improved existing protocols to extend the duration of in vitro plasmablast differentiation and showed that Rosa26(Cas9/+) B cells infected with Blimp1 or Xbp1 sgRNA-expressing retroviruses recapitulated the Blimp1 and Xbp1 mutant phenotypes in this proof-of-principle experiment. Moreover, Cre retrovirus-mediated deletion of Irf4, Ikaros and Aiolos strongly impaired plasmablast differentiation in this optimized system.     To discover new regulators of plasma cell differentiation, CRISPR/Cas9-based screens will be performed with pooled sgRNA libraries targeting all known upregulated genes in plasmablasts and plasma cells, followed by individual validation of the best hits. Selected top-ranked genes will be analyzed in vivo by conditional mutagenesis with newly generated, plasma cell-specific Cre lines. Regulated target genes of IRF4, Ikaros, Aiolos, XBP1 and the XBP1-regulated transcription factor Bhlha15 will be identified in plasmablasts by ChIP- and RNA-seq analyses. Target genes with potentially interesting functions will be further characterized by CRISPR/Cas9- or Cre/loxP-mediated mutagenesis.     These experiments will provide fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nanomist for fire suppression and explosion mitigation' (NANOMIST), addressing dissemination and exploitation.

assistant: **Impact**

NanoMist is the trade name for the proprietary process technology of producing, scaling, transporting, and delivering nano- to micron-sized droplets, particles and mists. These technologies can be used to produce ultra fine water mist systems for fire suppression and explosion control and serve as an environmental friendly replacement of Halon 1301. The proposal aims to carry out numerical investigations of the dynamic âStwo-wayâ interaction of ultra fine water mist droplets with flames in the context of fire suppression and explosion control. In particular the following four aspects will be investigated: (i) gas-phase cooling, (ii) oxygen depletion/dilution and (iii) surface cooling (likely to be negligible due to the ultra fine size) and (iv) the attenuation of thermal radiation. Both the Eulerin-Lagrangian and Eulerin-Eulerin approaches will be considered within the frame of an existing large eddy simulation (LES) code. The key objectives of the project includes: Â-Develop/implement SGS combustion models that will facilitate the investigation of the dynamic interaction between ultra fine water mist with fires and propagating flames which would otherwise lead to explosions. Â-Develop/implement a âStwo-wayâ coupling approach through which the influence of the mist droplets on the flow can be classified. Â-Develop a phase transition model for the mist formation and couple the model with an existing LES code. Â-Validate the model for the predictions of fire suppression and extinction effect of nanomist with published experimental data. Â-Validate the model for simulating the mitigation effect of nanomist on gas and dust explosions. Â-Establish a sustainable research programme with international collaboration on ultra fine watermist for fire suppression and explosion co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Measurement of cp violation using the kloe detector at the daphne collider' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The research work will be devoted to the measurement of the CP violation parameter Rf (et/e) in the KLKS system. The work will be made in the frame of the KLOE collaboration (18 laboratories, 140 members) working on the KLOE detector at the DAPONE e+e collider.  The research work will consist of 2 kinds of activities: the first activity will be devoted to the analysis of the data collected by the KLOE detector to reconstruct the decays of the KL and Ks mesons. This will require the development of computer programs in which selection criteria will have to be defined to reconstruct these particles. The second activity will consist of participating to the construction of the central drift chamber and the tests of its performances, to be compared with the expected ones. These tests will concern the resolution on the track parameters, losses due to the track fit and the efficiency of the background rejection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'FibroFix™ Cartilage, silk-based implant for cartilage repair and regeneration, introducing a new paradigm in osteoarthritis treatment.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

FibroFix™ Cartilage, silk-based implant for cartilage repair and regeneration, introducing a new paradigm in osteoarthritis treatment.Cartilage deterioration and injuries often lead to osteoarthritis (OA) – a long-term chronic disease resulting in bones rubbing together and creating pain, stiffness and severe disability. Knee cartilage injuries are very common and almost half of them go on to develop OA, which is second only to heart disease as a cause of work disability. Resulting from decreased qualityof life, hospitalizations and loss of productivity, the economic cost of OA is particularly high in every country that it has been estimated. Currently, all treatments available, including Total Knee joint Replacement (TKR) as the ultimate recourse, are inefficient and expensive: they involve pain, lengthy rehabilitation, frequent complications and high costs. Therefore, giventhe increasing prevalence of knee OA, its associated burdens and the drawbacks of all available treatments, it is becoming increasingly important to develop an innovative cost-effective solution to this major public health problem worldwide.FibroFix™ Cartilage is a well characterised, regenerative orthopaedic repair product to address the unmet and pressing clinical need of large and/or osteoarthritic articular cartilage lesions in the knee, developed by Orthox. It is biostable, biocompatible, emulates cartilage function and supports cartilage regeneration at the minimum cost effectiveness ratio. It allows resurfacing of large and/or potentially OA cartilage lesions, prolonged use of the joint, increased mobility, reduced pain and postponement or prevention of TKR. Smooth, robust, resilient, durable and lubricious, it is a unique combination to be applied in orthopaedics and biomaterials shifting th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding the top-down and bottom-up development of emotional styles in a modern colonial context: The case of the Jewish community in Mandatory Palestine' (ColEMP), addressing dissemination and exploitation.

assistant: **Impact**

How do emotional styles develop in colonial settings? What are their roles in the construction of settler identities? Such processes happen both “from below”—in the daily and often casual behavior of ordinary men, women, and children; and “from above”—in discourses about the ideal and actual characteristics of a settler. As the early Zionists, looking to execute their national project in the colonial world, fully realized, a colony, regardless of its function, always provides an opportunity to produce “new people.”  In the case of the Yishuv—the Jewish community that coalesced in Mandatory Palestine—the top-down direction of this process can be identified in the extensive Zionist literature about the desired “New Jew” as well as in the attempts to embed his or her traits using printed matter (such as parents’ manuals and children’s literature). Drawing on this feature of the Yishuv, the research analyzes both the Zionist project of top-down emotional transformation and the actual expression and experiences of emotions in the burgeoning settler society. By integrating these two levels, the research goes beyond the existing scholarship, which usually focuses on one or the other, and breaks new ground in understanding how emotions were mobilized and how new emotional styles emerged in a colonial context. The outgoing phase, which will last two years at Harvard University, under the supervision of Prof. Derek Penslar, has two aims: (i) to understand how the colonial context (within which early Zionism operated) impacted ideas about new emotional styles; and (ii) to survey the attempts to bring these ideas into the homes of (the mostly European) settlers at the time. The incoming phase, running one year at Bar-Ilan University, under the supervision of Prof. Hizky Shoham, wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'DElineation of Striato-CoRtical contrIbutions to BEhavioral symptoms in FrontoTemporal Dementia' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Second to Alzheimer’s disease (AD) in prevalence, frontotemporal dementia (FTD) is a neurodegenerative condition resulting from the progressive deterioration of the frontal and temporal lobes of the brain. Cognitive and behavioural impairments are the most early and prevalent characteristic of FTD. In numerous studies, these disturbances have been related to cortical atrophy, but recent findings suggest an early involvement of subcortical dysfunctions. Among these subcortical structures, it has been suggested that striatial atrophy is an early feature of FTD. The striatum has important structural and functional connections with frontal, temporal and insula regions, which have been all implicated in the generation of behavioural symptoms. Still, at this stage it is not clear how either cortical or striatal brain regions or their interaction generate these symptoms.In this project, we propose to characterize and contrast the integrity of the striatal subregions (nucleus accumbens, caudate nucleus, putamen) in FTD, AD and Parkinson’s disease (PD), which have respectively more cortical or striatal dysfunction, and in healthy aged controls. In addition, we will employ state-of-the-art structural and functional neuroimaging to delineate striatal and cortical contributions to behaviour in FTD and controls. Finally, we will develop novel tasks assessing the functions supported by striatal structures specifically. These tests will allow a clinical delineation of cortical and striatal degeneration at diagnosis.The results will lead to a better characterization of behavioural dysfunctions in neurodegeneration and in FTD particularly. This project will inform future diagnostic guidelines and disease modifying therapies in FTD. Also, in exploring the behavioural disturbances due to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Modernism and Illness Experience: Embodied Strategies of Textual Production'.

assistant: **Objectives**

The role that ill health plays in thematic concerns of modernist literature has been a topic of scholarly interest in recent years. Less considered, however, is the relationship between ill health and modernist practices of writing. The primary research aims of ModIX are to provide a sound methodology for exploring this relationship and to define modernist writing strategies and accommodations as they relate to authors’ illness experiences. Methodologically innovative, ModIX applies affect theory to genetic criticism in order to trace the author’s body as a tool and facilitator of writing. The project focuses on three key modernist authors who experienced illness to a life-altering degree: James Joyce (1882-1941), D. H. Lawrence (1885-1930) and Katherine Mansfield (1888-1923). Drawing together insights from affect theory, health humanities and archival studies, ModIX will reconstruct the literary geneses of Joyce’s Finnegans Wake, Lawrence’s Lady Chatterley’s Lover and selected short stories by Katherine Mansfield, all written during periods of the authors’ ill health and needs for care. ModIX’s research objectives are to consolidate affective genetic criticism as a methodology, to understand modernist illness experience phenomenologically, and to reconstruct the networks of care that surrounded these modernists as a result of ill health and creative needs. ModIX goes beyond the state of the art to understand the lived experience of illness not only as a biographical fact, but as a dynamic, material factor in shaping, facilitating and sometimes frustrating modernist literary labour and production. ModIX is an archival project that will produce original and impactful results. The project outputs will include three peer-reviewed articles in high quality journals, a monogr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Semi-classical dynamics on large systems using the MMVB method: Applications to photochemical switches and electron transfer systems' (MMVBSCD), addressing dissemination and exploitation.

assistant: **Impact**

The aim of this proposal is the study of the complex long-time dynamics of molecular switches and electron transfer systems. It will be achieved by the development of a hybrid approach allowing for highly accurate simulations on large chemical, biological and physical systems due to combination of quantum description for reactive center and classical force fields for surrounding molecular framework. The hybrid MM-VB (Molecular Mechanics ¿ Valence Bond) method which is proven to be a useful tool for studyin g non-adiabatic dynamics will be extended to solve a series of frontier problems in modern chemistry. The photochemistry of azobenzene and fulgides will be thoroughly studied because they are the prominent members of the family of photochemical molecular s witches and have a great potential in development of optoelectronic and photooptical devices. It will require generating reliable parameters for nitrogen and oxygen and calibration of the hybrid MM-VB force field. The second extension is based on the gener alization of the VB treatment of the quantum region. It will allow the MM-VB method to treat dynamics of charged species (for example, radical-cations). It will open access to dynamical studies of electron transfer in biological systems (for example, photo synthetic reaction) as well as to thorough analysis of conducting polymers. The project is based on the experience of the host and the applicant in theoretical methods for large molecules. It will result in new fundamental knowledge about photochemistry of molecular switches and electron transfer systems as well as in computer software for large-scale molecular simulations. The project will lead to the mutual benefit because the joint research will allow strengthening the methodological grounds of the hybri d qu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Massive Neutrinos: Investigating their Theoretical Origin and Phenomenology' (MANITOP), addressing dissemination and exploitation.

assistant: **Impact**

The aim of the proposed project is to shed light on the theoretical origin of neutrino masses and to explore the phenomenological consequences of the model predictions and of possible mechanisms giving rise to neutrino mass. The results of many upcoming experiments in the neutrino sector and beyond will be a crucial discriminator for models and will have to be followed closely. Apart from the usual neutrino oscillation observables, there are more model-dependent implications of neutrino mass models, for instance lepton flavor violating decays and electric dipole moments in the charged lepton sector, or processes involving new particles at colliders such as the LHC. The connection to the baryon asymmetry of the Universe, to dark matter and to proton decay will also be studied. Phenomenology will also be focussed on: in particular, the implications of upcoming (precision) experiments on the neutrino mass and mixing parameters or the neutrino mass matrix will be investigated. The prospects of using high energy neutrino cosmic rays, neutrinoless double beta decay (including analogous processes) and new experimental ideas to probe the parameters of neutrino physics will also be explored.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The mechanism, specificity and inhibition of enzymes belonging to the xanthine oxidase family : medical and industrial applications' (1998-2002).

assistant: **Concept**

Eight young post-doctoral scientists will be trained in the following advanced techniques; enzymology; x-ray crystallographic macromolecular structure solution; transient and steady-stake kinetics; bio-organic and bio-inorganic chemistry; fungal, bacterial, and mammalian genetics; protein purification and over expression systems; molecular modeling of compounds with site-specific molecular interactions with enzymes; continuous wave and pulsed multifrequency EPR and ENDOR .The training will take place in eight well-founded, internationally -recognized laboratories in five EU countries. The young researchers will generally receive training in at least two network laboratories and will make short visits to others. Other young researchers from network laboratories will make short visits to different participants for exchange of information and materials. Involvements in network and local seminar programmes will be encouraged as will short visits to the associated industrial laboratories.