RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Aerosols, Clouds, and Trace gases Research InfraStructure' in the context of a Horizon 2020 call.

assistant: **Objectives**

ACTRIS-2 addresses the scope of integrating state-of-the-art European ground-based stations for long term observations of aerosols, clouds and short lived gases capitalizing work of FP7-ACTRIS. ACTRIS-2 aims to achieve the construction of a user-oriented RI, unique in the EU-RI landscape. ACTRIS-2 provides 4-D integrated high-quality data from near-surface to high altitude (vertical profiles and total-column), relevant to climate and air-quality research. ACTRIS-2 develops and implements, in a large network of stations in Europe and beyond, observational protocols that permit harmonization of collected data and their dissemination. ACTRIS-2 offers networking expertise, upgraded calibration services, training of users, trans-national access to observatories and calibration facilities, virtual access to high-quality data products. Through joint research activities, ACTRIS-2 develops new integration tools that will produce scientific or technical progresses reusable in infrastructures, thus shaping future observation strategies.  Innovation in instrumentation is one of the fundamental building blocks of ACTRIS-2. Associated partnership with SMEs stimulates development of joint-ventures addressing new technologies for use in atmospheric observations. Target user-groups in ACTRIS-2 comprise a wide range of communities worldwide. End-users are institutions involved in climate and air quality research, space agencies, industries, air quality agencies. ACTRIS-2 will improve systematic and timely collection, processing and distribution of data and results for use in modelling, in particular towards implementation of atmospheric and climate services. ACTRIS-2 invests substantial efforts to ensure long-term sustainability beyond the term of the project by positioning the project i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'SAC robustness in the transition from meiosis to mitosis' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Meiotic divisions in the oocyte have been shown to be surprisingly error-prone compared to the reliable chromosome segregation that takes place in dividing somatic cells. The high frequency of chromosomal abnormalities found in pre-implantation embryos in mammals coupled with the fact that the first divisions of the embryo resembles meiosis in several aspects suggests that the mechanisms controlling chromosome segregation, most importantly the spindle assembly checkpoint (SAC), only become fully operational after the transition from meiosis to mitosis during early development. Despite the importance for early embryonic development, the sensitivity of mammalian embryos to light and the absence of a functional reporter of the SAC in mice have precluded real-time imaging of chromosome segregation and its control in the first embryonic divisions. Recent advances in light sheet microscopy in the Ellenberg lab now allow me to study chromosome segregation. In addition, in collaboration with the EMBL Transgenic Facility I will be able to rapidly generate the first SAC reporter mice that will permit me to test the checkpoint functionality up to the blastocyst stage.Taking advantage of this unique opportunity to combine new technology with a novel reporter animal model, I plan to study how the SAC changes from meiosis to the first embryonic divisions of blastocysts. To this end, I will analyze SAC signalling and dynamics and assess whether the robustness of the SAC increases with development. My project aims to improve our understanding of chromosome segregation during mammalian pre-implantation development, and therefore the results of my research will be important to shed light on the molecular causes of aneuploidy in the early embryo, fundamental for our understanding of infer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Thermal Magnetic Resonance: A New Instrument to Define the Role of Temperature in Biological Systems and Disease for Diagnosis and Therapy'.

assistant: **Innovation**

Temperature is a physical parameter with diverse biological implications and crucial clinical relevance. With an ever increasing interest in thermal applications, non-invasive in vivo methods to modulate temperature and characterize subsequent effects are imperative. Magnetic resonance (MR) is a mainstay of diagnosis but lacks inherent means for focal thermal modulation.Ultrahigh field (UHF) MR employs higher radio frequencies (RF) than conventional MR and has unique potential to provide focal temperature manipulation and high resolution imaging (ThermalMR). Our simulations show that we can adapt an UHF- MR device to generate heat in highly focused regions of tissue by using high-density RF transmitter arrays. This new instrument will provide a revolutionary method for precise in vivo temperature manipulations. To establish high-fidelity thermal dosimetry, we will investigate pioneering strategies that exploit electrical and heat transfer tissue properties. For thermal dosage control, novel methods of MR thermometry will be developed. The capacity of ThermalMR for thermal intervention will be demonstrated in model systems. Its efficacy for drug release will be explored using new thermo-responsive nanocarriers loaded with fluorinated probes, exquisitely quantifiable with 19F MR. The applicability and safety of ThermalMR will be demonstrated in animal models followed by a feasibility study in healthy subjects. To link thermal responses of MR contrasts with molecular signatures, gene expression profiling will be performed. The aim is to understand the thermal properties of healthy and pathological tissues and explore the use of temperature modulation as a therapeutic tool. ThermalMR will eradicate the main barriers to the study and use of temperature - a critical dimension
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Extracellular Vesicles and exosomes from adult stem cells in the regeneration of organ injury' (EVESTEMINJURY) targeting Seventh Framework.

assistant: **Abstract**

Acute and chronic kidney disease is a worldwide medical and public health problem in all developped and undevelopped Countries. It is clear that a large part of the bad outcome of end-stage renal diseas (ESRD) patients is due to deficient follow-up during the earlier chronic kidney disease (CKD) stages.The concept that extracellular vesicles and exosomes (EVs) by transferring extracellular RNAs can modulate the phenotype of target cells is an emerging paradigm in the intercellular communication. The extracellular RNAs are thus now considered as paracrine/endocrine signals. EVs contain diverse species of RNAs (mRNA, miRNAs and long non-coding RNAs) reflecting the functional state of the cell of origin. Recent studies on adult stem cell-induced tissue regeneration pointed out paracrine/endocrine mechanisms rather than permanent engraftment and trans-differentiation of stem cells. Therefore, the paracrine/endocrine hypothesis has changed the perspective of the therapeutic use of stem cells in regenerative medicine. Additionally, several studies indicate that EVs play a relevant role as mediators of stem cell induced regeneration by reprogramming injured cells.Within this project, we will explore the different necessary aspects in order to get a more profound knowledge on EVs, on their mechanisms of action in tissue injury, and on the definition of the most promising “active biological ingredients” of their content to further promote EV as new potential therapeutic strategies in the field of regenerative medicine. Also, within the EVStemInjury project, two different approaches of EV production will be explored: Biological and Synthetic, showing the different potential design strategies and to assess their efficiency. Finally, in order to explore the renoprotective effect of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'FT, a global regulator of plant flowering and architecture'.

assistant: **Innovation**

The floral transition has been an excellent system to study the molecular basis of primordia fate determination in response to environmental conditions in plants. In Arabidopsis, long days result in the transcription of the potent floral stimulator FT in the leaves. Transport of FT protein to the SAM enables an interaction between FT and FD to occur. This interaction leads to the expression of floral homeotic genes, and the subsequent programming of primordia as flowers. On the other hand, it is critically important for the plant to have a system for counteracting the floral promoting effects of FT/FD in part of the shoot to maintain vegetative stem cells and indeterminacy. In Arabidopsis, this role is carried out by TFL1, which acts in combination with FD to repress expression of flowering genes. In addition to FD, there is a paralog of FD, FDP, which appears to have similar functions to FD and be partially redundant with FD in activity. FDP has a very similar expression pattern to FD, and will therefore be considered in parallel with FD.  The main objectives of the research project described in this proposal are: on the one hand figuring out what the components required for the FT/FD/FDP signalling module are. For this purpose I shall screen mutagenised tfl1-1 plants since in the absence of TFL1 protein, FT activity is greatly enhanced and this plants therefore provide an excellent genetic system to search for additional factors that are required for FT signalling which might not be revealed in a wild-type situation where FT is usually limiting. Furthermore, I aim to know what the cis-elements determining FD/FDP expression are by using a series of transgenic plants containing deletions in FD and FDP promoters in order to characterise the elements within FD and FDP pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'SHAPE. Deciphering sarcoplasmic reticulum shaping in heart function'.

assistant: **Innovation**

Cardiovascular diseases (CDs) are the main cause of death in the European Union (EU) and they cost the EU €210 billion a year. Expanding the molecular knowledge on CDs is a key factor in the struggle against them. The sarcoplasmic reticulum (SR) is one of the chief organelles involved in proper cardiomyocyte function due to its implication in calcium handling, and because of that, one of the principal therapeutic targets. SR comprises at least two different regions whose function is well known, however the molecular actors that profile it and how the correct arrangement of them is obtained remain unknown. In contrast, endoplasmic reticulum (ER) shaping and how changes in its shape affects ER function have been recently described. Due to this shape/function relationship and considering the similarities between ER and SR, it is likely that SR shape modulators are fundamental also in maintaining proper SR function. In this scenario, it is tempting to speculate that ER shape alteration is involved in the development of CDs. The aim of this project is to study how the SR shape affects its function. This ambitious goal will be achieved by bringing together my expertise in cardiac physiology with the know-how of my supervisor in ER shape/function and my co-supervisor knowledge on calcium signalling, by using the powerful genetic model Drosophila melanogaster. The results of the project will impact the cardiac function knowledge and could provide possible new therapeutic targets against CDs. Moreover, the results of the project could impact other fields of research, as well as muscular research, by expanding the understanding of SR shape/function relationship.


**Keywords:** Heart, Calcium, Drosophila melanogaster, Sarcoplasmic Reticulum, Endoplasmic Reticulum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Flexible assembly processes for the car of the third millennium'.

assistant: **Innovation**

The decreasing lifecycle times of car models and the increasing number of variants require from automotive industry to design and operate assembly plants and production networks that are completely flexible, capable of switching from producing one model to another to meet fluctuating and diverse demand.A key issue in order to succeed in such diverse, complex and customer driven market-context is to produce on-demand products of high complexity, while improving quality and product-service life cycles.my-Car will develop a new paradigm in the way modern passenger cars are assembled, enabling ultimate degree of car customisation, which could, in its outmost extent, allow every customer purchasing his unique car.This paradigm will be formed on the basis of the self-adaptive assembly plant. my-Car will further develop and integrate technologies that will facilitate the vehicle assembly process into becoming self-adaptive to any kind of market variation and capable of producing cars with extended degree of personalization. my-Car aspires at improving the ability of the automotive industry to integrate the customer into its assembly processes.my-Car recognizes the need of developing assembly concepts that are completely flexible in all their aspects (machine/robot/floor level, system suppliers and supply chain). The implementation of the self-adaptive car factory concept will be the radical innovation of the IP.my-Car aims at increasing by 10% the market share for European automotive car industry, reducing by 15% assembly costs, shortening by 15% the time to market and decreasing investment costs by 20% by promoting assembly equipment reusability.The IP's Consortium includes major stakeholders of the European automotive industry, namely a Core Users Group, a group of productio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'BRIdges the GAp for Innovations in Disaster resilience' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Recent studies from the IPCC indicate that Europe is particularly prone to increased risks of river and coastal floods, droughts resulting in water restrictions and damages from extreme weather such as heat events and wildfires. Evaluations also show a huge potential to reduce these risks with novel adaptation strategies. Researchers, innovators and incubators develop innovative products and services to reduce the increased climate change risks. Many of these innovations however hardly arrive at the markets. BRIGAID BRIdges the GAp for Innovations in Disaster resilience. BRIGAID's approach is supported by three pillars.  (1) At first BRIGAID takes into account the geographical variability of climate-related hazards and their interaction with socio-economic changes, (2) BRIGAID establishes structural, on-going support for innovations that are ready for validation in field tests and real life demonstrations and (3) BRIGAID develops a framework that enables an independent, scientific judgement of the socio-technological effectiveness of an innovation. BRIGAID's objective is ambitious but achievable with strong consortium partners in EU, two Associated Countries and support from Overseas Territories. BRIGAID (a) brings actively together innovators and end-users in Communities of Innovation, resulting in increased opportunities for market-uptake; (b) contributes to the development of a technological and performance standards for adaptation options by providing a Test and Implementation Framework (TIF) and test facilities throughout Europe; (c) Improves innovation capacity and the integration of new knowledge by establishing an innovators network and (d) strengthens the competitiveness and growth of companies with the support of a dedicated business team. Finally BRIGAID deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A novel high-throughput tool to genotype human genome inversions for personalised medicine', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The completion of the Human Genome Project has generated a new industry of personal genomics and personalized medicine, which aims to determine the entire DNA sequence of an individual to predict possible disease risks and improve treatment. However, despite the initial high expectations, it has not been possible to find the genetic causes for many common and complex diseases. Most of the work has been focused in one type of genetic variants, the single nucleotide variants or SNPs, but it has been recently shown that there are many other changes affecting larger regions of the genome, known as structural variants. One type of structural variant that has been implicated in functional differences between individuals and genetic diseases are inversions. Nevertheless, they have been poorly studied due to technical difficulties and there is not a global methodology to determine their presence in a quick and easy way. As part of the INVFEST ERC Starting Grant, we have developed a novel high-throughput screening technique for genotyping multiple inversions in hundreds of individuals. This project proposes the generation of a proof of concept package to move forward in the development of an innovative diagnostic kit of human genome inversions to be licensed to an industrial partner for its commercialization. To achieve this, the main goals are: (1) Optimizing the methodology by decreasing the amount of DNA needed and increasing the coverage to most known human inversions, especially those clinically relevant; (2) Strengthen the current patent through a freedom to operate study and a patent cooperation treaty application, and (3) Analyze the market to determine needs in inversion genotyping and compile feedback from the potential licensees and end-user companies. The availabilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Safety standards for road design and redesign' under Fourth Framework.

assistant: **Concept**

The overall objective of the project is the formulation of safety arguments for selecting certain design elements or for recommending certain dimensions. Main output of SAFESTAR will be recommendations for design guidelines or possible standards on the basis of road safety considerations.SAFESTAR will concentrate on roads that can be part of the TERN network, i.e. primarily motorways, express roads and major interurban roads. In addition, some attention will be devoted to urban conditions. %Main expected deliverables and status (C, R or P)*D1.1: Report on Motorways, emergency lanes, shoulders and verges (P)D1.2: Report on Criteria for safety devices on motorways (P)D2.1: Literature review on tunnel design and road user behaviour (P)D2.2: Report on Tunnel design (P)D2.3: Report on Validation of design features in simulator (P)D3.1: Report on Accident analysis on express roads (P)D3.2: Report on Decision making processes (P)D3.3: Workshop (P)D3.4: Report on Safety standards for express roads (P)D4.1: Report on Safety evaluation of different kinds of cross-section (P)D4.2: Report on Head-on and run-off accidents (P)D4.3: Report on Alternative measures to prevent severe accidents (P)D5.1: Literature review on Design of curves in rural roads (P)D5.2-4: Report on Validation of assumptions, speed profile models, and accident models (P)D5.5: Final Report: Best practice for European safety guidelines (P)D6: Report on Marking of bends in rural roads (P)D7.2: Report on Major urban junctions (P)D7.4: Report on review study and empirical studies on major urban junctions (P)D8: Report on Safety Audits (P)D9.2: Final Report (P)*C = Confidential R = Restricted P = PublicDeadlines for deliverablesD1.1: Jun 97D1.2: Jun 97D2.1: Nov 96D2.2: Apr 97D2.3: Jan 98D3.1: Mar 97D3.2: Mar 97D3.3: A