RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Establishment of a Neutrophil elastase Activity home test for the Better management and treatment of Lung Exacerbations' (ENABLE), addressing dissemination and exploitation.

assistant: **Impact**

Chronic obstructive airways disease (COPD) is a leading cause of death of increasing prevalence worldwide and is characterised by progressive airflow reduction, breathing difficulties and irreversible lung damage.  Management of COPD varies extensively, with patients not receiving proactive disease management at greater risk of poorer outcomes. Routine measurement of an active protease (enzyme) biomarker called neutrophil elastase (NE) will empower clinicians and patients to adopt proactive approaches to disease management and treatment, reducing exacerbations and emergency hospital admissions. Our goal is therefore to develop a novel, simple to use ‘Point-of-Care’ (PoC) test that will improve patient outcome and reduce the clinical, societal and economic burdens associated with chronic respiratory disease (CRD). The activity of NE (NEa) in the airways is known to correlate with the severity of several CRDs such as COPD, cystic fibrosis (CF) and bronchiectasis, and importantly is highly predictive of infection and an early marker of exacerbation. Our novel device, NEATstikTM (Neutrophil Elastase Airways Test), will enable the rapid measurement of NEa at PoC and has been designed for home use (patient self-management) in mind, with a view to remote monitoring. It is expected that this test will help to improve patient management and outcome, with the ultimate goal of reducing the individual, European and global burden of COPD. This phase 1 proposal is to provide a feasibility assessment which will maximise the potential for success the clinical validation of NEATstikTM, a PoC device that will enable the proactive management of chronic respiratory diseases such as COPD.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Optical Probe and Manipulation of Magnetization at the nanometer scale' to be submitted under Seventh Framework.

assistant: **Abstract**

This project focuses on fundamental scientific issues of spin manipulation in nano-structured magnetic materials subject to optical/magnetic excitations and further provides the scientific underpinnings of next generation of heat-assisted magnetic recording (HAMR). The research will focus on two related research themes (i) ultrafast magnetization dynamics, (ii) optical switching of nanomagnets which have the common property of using optical pulses to both probe and manipulate magnetism at the nanometer spatial and femto-second temporal scales.The strength of this project is to address a novel and challenging scientific program by bringing together international experts with complementary expertise:Ultra-fast optical (Y.Fainman UCSD)Nanomagnetism and spintronic  (S.Mangin SM the applicant)Nanomagnetic theory and modeling (V.Lomakin UCSD)Magnetic data storage  (E.E. Fullerton EEF the outgoing host)The partner organisation CMRR at the University of California, San Diego (UCSD) is directed by EEF. This famous research centre serves as a catalyst for joint investigations between industrial and academic partners. EEF is an outstanding scientist (235 papers, 80 invited talks, 48 US patents, h factor = 42).The collaboration between EEF and SM has already been very active and productive in the past. This program will be a unique opportunity to take the collaboration to a higher level on an innovative and original scientific project and on a broader scale (with new members and student of both partner and host organisation). Since both collaborators are taking more responsibilities a strong trans-Atlantic collaboration will be profitable for their carriers and their institutions. It is also an exceptional chance to bring back to the host organisation competence and knowledge on th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'SHARING A GENOME: CASTE ANTAGONISM AND COADAPTATION IN SOCIAL INSECTS' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Eusociality, in which workers sacrifice their own reproduction to rear the offspring of queens, is a major focus of interest in evolutionary biology. A key aim during recent decades has been to understand the conflicts of interest within eusocial groups. In contrast, however, little is known about the underlying genetic architecture. In this proposal, we will use a mixture of field experiments and transcriptomics to address novel questions about the evolutionary dynamics of queen-worker interactions. Borrowing concepts from the field of sexual conflict, we will investigate a new idea: that the productivity of social groups is limited because castes are constrained by inter-caste genetic correlations from simultaneously reaching their optimal (dimorphic) phenotypes. We will also quantify caste dimorphism across an environmental gradient, and investigate the plasticity of dimorphism using transplants and social manipulations. In addition, we will cross-foster individuals between nests to test for coadaptation between queens and workers. And we will test a long-standing hypothesis experimentally for the first time: that queens manipulate worker phenotype in their own interests. The proposed research will force us to look at eusociality in a completely new way. How caste dimorphism can evolve, the possibility that its evolution could be limited by genetic constraints, and the processes that could resolve those constraints, are topics that have hardly been considered. Recent research has strongly emphasized conflict between queens and workers, but the coadaptation of complementary phenotypes may be just as important. Our approach will be multidisciplinary: we will capitalize on state-of-the-art transcriptomic technology in combination with innovative field methods, and use s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mechanisms and functions of microtubule plus end tracking proteins in mammalian cells: development of inhibitory strategies' to be submitted under Seventh Framework.

assistant: **Abstract**

Microtubule plus end tracking proteins are a group of factors that accumulate specifically at the ends of growing microtubules where they control microtubule dynamics and the interactions with different structures, such as mitotic kinetochores, actin cytoskeleton and the cell cortex. The core components of the microtubule plus end tracking machinery are End Binding (EB) proteins, such as EB1, which autonomously track the growing ends of microtubules and recruit to microtubule tips multiple functionally diverse proteins. The aim of this proposal is to use a wide range of microtubule-targeting anti-cancer compounds to systematically probe their effects on the microtubule-EB binding and thus gain insight into the basis of the enigmatic plus end recognition mechanism by the EBs. We also intend to use the detailed knowledge of the mechanisms underlying the interactions of EB proteins with their partners to develop novel reagents to inhibit microtubule plus end tracking of a broad range of proteins and thus probe the general significance of this phenomenon. In addition, we plan to use this knowledge to develop new tools to efficiently visualize growing microtubule ends in different cellular settings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Translational Training network on the Cellular and Molecular Bases of Heart Homeostasis and Repair'.

assistant: **Concept**

The CardioNeT Initial Training Network aims to implement a highly multidisciplinary, intersectoral and competitive training programme in cardiovascular research  through cutting-edge projects and extensive training in complementary areas.CardioNeT training comprises two tightly linked components - research and complementary training - that will be implemented at local as well as network level and which will be united by individual personal career development plans carefully elaborated for each researcher recruited. The training will be complemented by intersectoral secondment opportunities offered by industrial and academic partners.Research training•  Theoretical and technical local training by the different network partners, integrating knowledge from holistic molecular and cellular biology approaches with the aim to better understand the regulation of heart development and disease and to provide novel therapeutic alternatives•  A variety of Network courses and workshops providing theoretical and practical training, from bioinformatics to advanced non-invasive imagingComplementary training•  Complementary skills acquired through participation in local PhD programmes•  A range of different activities covering various aspects of complementary training, from presentation skills, to grant applications, management, IPR and Science & Society courses.The programme will be implemented by a network consortium comprising eleven partners from both the public and industrial sectors which is further enhanced by the participation of two associated partners. Researchers who participate in the CardioNeT training programme will benefit from a significant improvement of their career prospects that will be further strengthened by the trans-national and trans-sectoral collaborations that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Marketable sludge derivatives from sustainable processing of wastewater in a highly integrated treatment plant' under Seventh Framework.

assistant: **Concept**

This project researches, develops and demonstrates a toolkit of novel processes together with market development for advanced sludge-derived products and integration methodologies that can be applied to a range of wastewater treatment plants based on a typical municipal scenario. Supporting economic and life cycle assessment of the resulting gains in energy efficiency and conversion of renewable carbon, together with an implementation strategy based on a product mix with optimal value, will inform step changes that contribute to achieving more secure and sustainable sludge treatment and management practices in Europe while reducing pressure on natural resources and reliance on manufactured fertilisers.  Addressing key sludge management issues in the context of EU climate change mitigation and energy policies, the project concentrates on novel processes for sludge volume reduction, more efficient treatment and downstream processing for high quality sludge derivatives together with application protocols and assessment of the pathogen risk and long term soil impact for greater public confidence. Using an integrated approach with emphasis on the whole wastewater treatment system, the project promises innovative system solutions that have the potential to achieve up 20% annual carbon savings for the water industry by 2020 and ultimately could deliver up to 15,791,131 tCO2e pa savings for Europe.  Composing of 14 partners including 7 SMEs from industry, academia and Government establishments, the Consortium is a balanced mix of highly qualified and committed individuals that are well-placed to tackle the technical challenges, disseminate the results and to exploit the €17.5 billion market for new environmental equipment that will be opened up by the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Cardiovascular Diseases Diagnoses by means of Smart Remote Monitoring System based on known Heart Activity Biomarkers'.

assistant: **Innovation**

Cardiovascular Diseases are the leading global cause of death, accounting for 17.3 million deaths per year, a number that is expected to grow to >23.6 million by 2030. In Europe, it accounts for over 4 million deaths each year which means nearly half 47% of all deaths. Overall CVD is estimated to cost the EU economy almost €196 billion a year. It is clear that there is an economic demand to implement cost effective measures to early diagnoses of CVD and detection of highs risks to suffer a fatal event. The WHO has prioritized these interventions as: early identification of people at high risk in primary care and monitoring of survivors of a heart attack or stroke which are at high risk of recurrences or dying from them. Indeed, spurred by the hefty bill and lack of resources, Hospitals are continuously looking for new solutions to allow them to discharged chronical inpatients who can be remotely monitoring improving its quality of life and providing tailored treatment.The project HELMO aims at developing and clinically validating a no-invasive remote monitoring medical device for the early diagnoses of cardio vascular diseases (CVD) and to provide assistance before fatal consequences, even death. The  product will be launched to the market as an innovative system able to monitor remotely 10 vital parameters which are well known biomarkers of CVD diseases: ECG – 12 leads ECG -, heart and breath rates, blood pressure, movement, oxygen saturation, body temperature, sweat, calories, location. This device, designed by all population including special needs group, will provide alerts both patients and clinicians at critical moments which can lead to loss of consciousness and death.    As a result, the number of hospitalization caused by CVD and eventually the deaths will expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Botanical plant Protection agent from Larix by-products' under Seventh Framework.

assistant: **Concept**

The main objective of ProLarix is to facilitate the translation of an innovation developed under  FP7 project ForestSpeCs from an intriguing concept to a business model for European SMEs in forestry and the agricultural sector.The potential use of bioactive extracts of by-products of the forest industry was evaluated under FP7 project ForestSpecs. Constituents of Larix by-products (‘Larixyne’) were demonstrated to have a high potential to be developed into a fungicide (plant protection product, PPP) with (i) high efficacy against a key disease of agriculture, (ii) an favourable environmental profile with respect to environmental impact and use of renewable resources, as well as (iii) a high potential to generate added value in the forest industry and European production of ‘smart’ crop protection technologies.Bringing potential plant protection products to the market necessitates substantial investments in the development of the registration dossier and market development. It is therefore essential to provide a priori information in order to predict the scale of investments as well as the time needed for registration of a novel PPP under EU legislation.ProLarix will therefore (i) pilot production and uses of Larixyne, (ii) validate efficacy and demonstrate its value as a PPP in European grapevine production systems, (iii) demonstrate the avenue to large scale production of high quality product, (iv) fill in data gaps and provide an initial data set to be used for future registration and (v) develop a road map for the development of a full dossier and capture of the market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Paleo-nutriet dynamics in the Eurasian Arctic Ocean' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Due to anthropogenic climate change, the Arctic Ocean (AO) is warming rapidly and sea ice is retreating dramatically with a loss of ~40% since 1980. Sea ice retreat will have complex effects on nutrient availability and, subsequently, primary productivity with implications for atmospheric CO2 sequestration through sedimentary organic carbon burial. Nutrient cycling in the AO is poorly constrained in the modern and even less is known about how nutrient delivery will evolve as sea ice continues to retreat. For the proposed project (PaNDA), I would move from the United States of America to Newcastle University in the United Kingdom to undertake a project designed to improve our understanding of how nutrient dynamics in the Eurasian Basin of the AO evolve under warmer climate conditions, which is extremely timely given the rapid warming occurring in the AO due to modern climate change. PaNDA is in line with the research priorities identified in Horizon 2020, as it focuses on both climate change and the Arctic region. PaNDA aims to reconstruct nutrient cycling over the last ~150 ka from sediment samples and pore waters collected north of Svalbard during the 2015 TRANSSIZ expedition (“Transitions in the Arctic Seasonal Sea Ice Zone”), focusing on two previously identified warm periods of sea ice minima, the Early Holocene (11-13 ka) and Marine Isotope Stage 5e (116-129 ka). Nutrient records will focus on changes in the cycling of major bioessential nutrients (phosphorus, nitrogen, and silica) and the main biolimiting micronutrient (iron) reconstructed using bulk elemental concentrations, sequential extractions, and isotope geochemistry. My background in Quaternary paleoceanography and carbon and nitrogen cycling will complement the Arctic experience and inorganic biogeochemic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'A new look at prostitution in medieval Europe: Exploring the potential of ancient pathogen genomics with individuals buried in red light districts.'.

assistant: **Objectives**

SEXWARC contributes to a paradigm shift in the archaeology of prostitution. The discipline has thus far mainly been limited to a description of the structural features of which brothels are constituted, but struggles to make meaningful observations when it comes to the people who have worked in these environments. This project aims to put female sex workers back at the centre of our scientific work, by focussing on human remains as a new source of information for the study of past sex work.The main objective is to get a grip on the health and living conditions of these women in the Middle Ages. I will do this by combining – for the very first time – recent advances in ancient DNA research of pathogens with some unique skeletal populations excavated in identified red light districts of medieval cities in the County of Flanders.As a crossover between the archaeology of sex work and ancient pathogen genomics, I will integrate both the Division of Medieval Archaeology and the Archaeo- and Paleogenetics group at the University of Tübingen. Under the supervision of Prof. Dr. Natascha Mehler and mentoring of Prof. Dr. Cosimo Posth, globally acknowledged as experts in their respective domains, this Action will allow to establish myself as an independent scholar with a highly strategic profile and as a future leader of an interdisciplinary research group in historical archaeology.


**Keywords:** sex work,  osteoarchaeology,  Middle Ages,  pathogens,  ancient DNA