RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integration of the Biochemical and Mechanical Networks of Cell Division' (BIOMECANET) targeting Horizon 2020.

assistant: **Abstract**

Cellular and sub-cellular organisation at the micrometre length scale ultimately reflects the activity of molecular networks that harness chemical energy to perform precise mechanical work, create functional spatial gradients, and sustain timely temporal changes in molecular activities. In eukaryotic cell division, the biochemical oscillations of the cell cycle drive dramatic morphological changes of the cytoskeleton necessary for bi-orientation of chromosomes and for their subsequent delivery into two daughter cells. This mechanism is at the heart of biology, but it is poorly understood and hard to address because it involves out-of-equilibrium chemistry of many components and Brownian mechanics of the cytoskeleton. BIOMECANET’s extraordinarily ambitious goal is to unravel this interplay by re-engineering it in vitro and by modelling it in silico. To achieve this, BIOMECANET will mobilize an unrivalled catalogue of purified human proteins to reconstitute four fundamental and interlinked biochemical and mechanical protein networks: 1) the cell cycle oscillator with the spindle assembly checkpoint; 2) the metaphase spindle; 3) the chromosome bi-orientation machinery of kinetochores; and 4) the central spindle and its links with the actin cytoskeleton required for cell fission. Then, BIOMECANET will combine these reconstituted networks, integrating temporal control and mechanical forces to analyse the emergence of complex life-like biological function, thus elevating scale and scope of in vitro reconstitutions to an entirely new level. Crucial to the attainment of BIOMECANET’s long-term goals is the synergetic alliance of two biochemists having pioneered different types of biochemical reconstitutions in the complementary areas of cell cycle and chromosome biology (Musacch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European prospective investigation of ischaemic heart disease and nutrition' (EPIC-HEART).

assistant: **Concept**

- To investigate the relationship between diet and fatal myocardial infarction, as an expression of ischaemic heart disease (IHD) in nineteen cohorts in nine European countries (Denmark, France, Germany, Greece, Italy, Netherlands, Spain, Sweden, United Kingdom);- To obtain this information in the same cohorts enrolled - for the purpose of studying the relationships between nutrition and cancers at major sites - in the European Prospective Investigation into Cancer and Nutrition (EPIC) and associated studies coordinated by the International Agency for Research on Cancer, this being of considerable public health relevance for deriving overall dietary recommendations.The direct objective of the EPIC-HEART project is to investigate the relationship between diet and fatal myocardial infarction, as an expression of ischaemic heart disease (IHD), in nineteen cohorts in nine European countries (Denmark, France, Germany, Greece, Italy, Netherlands, Spain, Sweden, United Kingdom) enrolled in the European Prospective Investigation into Cancer and Nutrition (EPIC) and associated studies, coordinated by the International Agency for Research on Cancer, already including nearly 200 000 subjects, the largest ongoing prospective study of any kind in Europe.In addition to investigating the role of all main foods and nutrients the study focuses in particular on:(a) foods and food patterns as typically represented in Mediterranean diets rich in fresh fruits and vegetables, grains and cereals;(b) alcoholic drinks;(c) two groups of nutrients, namely: (i) long-chain polyunsaturated fats of the omega-3 family, in particular alfa-linolenic an eicosapentenoic fatty acid, and (ii) antioxidants, in particular vitamin C, alfa-tocopherol, retinoids and selenium as well as the antioxidant profile (e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A TRUSTworthy speech-based AI monitorING system for the prediction of relapse in individuals with schizophrenia' (TRUSTING) targeting Horizon Europe.

assistant: **Abstract**

Schizophrenia affects a staggering 21 million people worldwide, with 80% of these citizens suffering from a relapsing disease, putting their health and safety at enormous risk. Timely detection of these psychotic relapses would require very frequent contact with clinicians, which is neither desirable nor feasible. An accurate online relapse predictor could alert clinicians of subtle deterioration, which enables timely intervention and allow safe discontinuation of long-term medication, which so many affected citizens desire. Our Consortium demonstrated that subtle alterations in speech carry a predictive signal for psychosis onset. This project will develop an AI monitoring system that leverages spoken language processing (SLP) and natural language processing (NLP) of speech recorded at home to calculate the relapse risk.  The monitoring tool we develop will be validated retrospectively in a longitudinal cohort, cross-sectionally, across six languages, after which it will be tested prospectively in a multicenter randomized trial, with the end goal of improving functional and clinical outcomes of those affected by schizophrenia. Developing such a system for exceptionally vulnerable people requires ‘buy-in’ from clinicians and mental health care service users, namely trust. A lack of trust is the biggest obstacle to the real-world implementation of a speech-based monitoring system. TRUSTING will develop a framework that systematically ensures addressing all the criteria for trustworthy AI put forward by the EU. This will ensure an empirically based and validated tool that can reliably detect pending relapse. As the core philosophy of trustworthiness is part of every aspect of the project, it will be a system more likely to be welcomed and embraced by service users and the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Developing biochemical and molecular markers for determining quality assurance in the primary processing of cocoa in west africa'.

assistant: **Objectives**

The main purpose of the project is to improve the current quality assessment practices used both by producers and buyers of cocoa in West Africa, which are currently based on subjective parameters. The project will carry out detailed microbiological and biochemical analysis of the fermentation process as well as handling methods, from the field to drying and storage, in order to identify biological or chemical markers and to relate these to the quality of the final product. The aim is to develop a set of objective quality indices which provide a more objective indication of cocoa quality and which can be used in the laboratory and in the field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cephalopod resources dynamics: patterns in environmental and genetic variation' to be submitted under Fourth Framework.

assistant: **Abstract**

The aim of this proposal is to improve understanding of the variability in distribution, abundance, and biological characteristics of economically important cephalopod stocks of EU waters of the Northeast Atlantic and Mediterranean.Specific objectives are:1. To develop a GIS system for cephalopod fisheries in European waters and to integrate fishery, survey, and environmental data at appropriate temporal and spatial scales.2. To refine the quantitative description of seasonal and inter-annual patterns of distribution and abundance of fished cephalopods and to develop models to predict their abundance from biotic and physical oceanographic parameters.3. To use microsatellite DNA variation as an indicator of stock structure and interactions of neritic and oceanic cephalopod resources through the use of DNA marker tags", supplemented with allozyme and mitochondrial DNA (mtDNA) studies.4. To integrate the new environmental and genetic approaches with recent findings on biological variability in the European cephalopod populations of the north east Atlantic and Mediterranean to evaluate whether this variation is due to plasticity of responses to environmental conditions or due to underlying genetic variation.METHODOLOGY AND RESEARCH TASKSThis project is still in its 1st year and progress has not yet been evaluated at full project co-ordination meetings. Consequently further details are given here of the proposed methodology and research tasks.Task 1. Environmental Variation To investigate the relationships between environmental conditions and the distribution and abundance of fished cephalopods of the Northeast Atlantic, Mediterranean and Saharan Bank by means of the development of GIS together with related statistical analysis and modelling work. The main cephalopod categor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'HIgh storage density solar power plant for FLEXible energy systems' (HIFLEX) targeting Horizon 2020.

assistant: **Abstract**

The HIFLEX (“HIgh Storage Density Solar Power Plant for FLEXible Energy Systems”) proposal has the ambition to develop and demonstrate a complete pre-commercial flexible CSP prototype plant featuring cheap solid particles as storage and heat transfer medium. Operation of the thermal storage system over a temperature span of 700°C results in a 2.5x higher storage density and 50% lower cost. During the project a complete pre-commercial solar tower system will be developed and built. The system will be located at a Barilla pasta plant in Foggia, Italy, with the following components: a 20 MWh thermal storage able to provide 800 kWth for 24h, innovative solar particle receiver with 2.5 MWth peak power, heliostat field with about 6000m² of mirror area, a 620°C particle steam generator, a 100 kW electric heater and a 800 kW fuel heater. Fast ramping steam generation at 620°C enabling grid balancing will be demonstrated. The renewable-fuel heater ensures weather-independent availability. Further support of grid stability is achieved by using excess or cheap power from the grid to charge the storage for time-shifted electricity production (power-to-heat-to-power).Continuous long-term operation for 18 months will be conducted to prove the performance. The project aims to verify the technical maturity of the technology for market introduction. Based on the experience from the pre-commercial prototype, the cost reduction potential for a 100 MWe solar tower plant will be validated, as well as the least-cost mix of renewables (PV, wind power, CSP, storage capacity, power-to-heat capacity, renewable fuel) for the future commercial application at Barilla as CHP system will be evaluated.A business plan will be developed for fast market introduction of the technology. The project will pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modeling cytoplasmic trafficking and molecular delivery in cellular microdomains' in the context of a Seventh Framework call.

assistant: **Objectives**

Cytoplasmic motion is a key determinant of organelle transport, protein-protein interactions, RNA transport and drug delivery, to name but a few cellular phenomena. Nucleic acid trafficking is important in antisense and gene therapy based on viral and synthetic vectors. This proposal is dedicated to the theoretical study of intracellular transport of proteins, organelles and DNA particles. We propose to construct a mathematical model to quantify and predict the spatiotemporal dynamics of complex structures in the cytosol and the nucleus, based on the physical characteristics and the micro-rheology of the environment (viscosity). We model the passive motion of proteins or DNA as free or confined diffusion, while for the organelle and virus motion, we will include active cytoskeleton-dependent transport. The proposed mathematical model of cellular trafficking is based on physical principles. We propose to estimate the mean arrival time and the probability of viruses and plasmid DNA to arrive to a nuclear pore. The motion will be described by stochastic dynamics, containing both a drift (along microtubules) and a Brownian (free diffusion) component. The analysis of the equations requires the development of new asymptotic methods for the calculation of the probability and the mean arrival time of a particle to a small hole on the nucleus surface. We will extend the analysis to DNA movement in the nucleus after cellular irradiation, when the nucleus contains single and double broken DNA strands (dbDNAs). The number of remaining DNA breaks determines the activation of the repair machinery and the cell decision to enter into apoptosis. We will study the dsbDNA repair machinery engaged in the task of finding the DNA damage. We will formulate and analyze, both numerically and an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Novel Materials Discovery Laboratory' (NoMaD) targeting Horizon 2020.

assistant: **Abstract**

Essentially every new commercial product, be they smart phones, solar cells, batteries, transport technology, artificial hips, etc., depends on improved or even novel materials. Computational materials science is increasingly influential as a method to identify such critical materials for both R&D. Enormous amounts of data, precious but heterogeneous and difficult to access or utilise, are already stored in repositories scattered across Europe. The NoMaD CoE will open new HPC opportunities by enabling access to this data and delivering powerful new tools to search, retrieve and manage it.NoMaD will foster sharing of all relevant data, building on the unique CECAM, Psi-k and ETSF communities, putting Europe ahead of materials science in other continents. Unprecedented, already initialised networking with researchers, with industry, with students and with other stakeholders will guarantee relevance and end-user value.  NoMaD will become a crucial tool for atomistic simulations and multi-scale modelling in the physical, materials, and quantum-chemical sciences. This field is characterised by a healthy but heterogeneous eco-system of many different codes that are used at all HPC centers worldwide, with millions of CPU hours spent every day, some of them at petascale performance. NoMaD will integrate the leading codes and make their results comparable by converting (and compressing) existing inputs and outputs into a common format, thus making these valuable data accessible to academia and industry:NoMaD will develop “big-data analytics” for materials science. This will require novel algorithms, e.g., for statistical learning based on the created materials encyclopedia, offering complex searches and novel visualisations. These challenges exploit the essential resources of ou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Comprehensive photophysical study of lead-free halide perovskite nanocrystals: towards eco-friendly and high-performance light-emitting diodes' (PHOLED) under Horizon Europe.

assistant: **Objectives**

This project (PHOLED) will concentrate on lead-free halide perovskite nanomaterials for their light-emitting diodes (LEDs) application to address the current low-performance issue. The focus of this project will be the synthesis of novel lead-free layered halide double perovskite nanocrystals with surface engineering, and the corresponding mechanism studies, which account for the fabrication of high-performance perovskite LEDs (PeLEDs). PHOLED will combine multidisciplinary research crossing synthetic chemistry, surface chemistry, electrochemistry, photophysics, and optoelectronics. The completion of PHOLED will result in the generation of new knowledge to synthesize novel lead-free perovskite nanocrystals with outstanding optoelectronic properties which can provide crucial hints for chemists to enable further optimization of high-quality lead-free perovskite nanomaterials. An achievement of low-cost and high-performance lead-free-based PeLEDs from PHOLED will significantly highlight the possibility of the replacement of conventional LEDs that are made of exotic semiconductors such as gallium arsenide and gallium phosphide. The replacement of toxic lead by less- or non-toxic lead-free metals achieved by PHOLED will also have benefits for both environment and human beings. This fellowship will allow the researcher to incorporate the study of emerging lead-free perovskite nanomaterials-based LEDs into his research profile, broaden his knowledge and offer the researcher further expertise in the fields of eco-friendly, low-cost, and high-performance PeLEDs, opening new horizons for expanding his career prospects. New technical skills and expertise obtained during the fellowship in the beneficiary institute will strengthen the researcher's experimental capabilities and explo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'InTEGRATED FEED CONTROL OF SPREADING AND CUTTING TABLES FOR THE DISTORTION-FREE MECHANICAL TRANSPORT (FEED) OF GARMENTS WITH RESPECT TO PATTERN AND TEXTURE' under Fourth Framework.

assistant: **Concept**

The mechanical transport of large area flexible goods is usually provided by roller systems. In many industrial examples the mechanical systems acts as a feed, i.e. pushing instead of pulling. During garment manufacture the textile good is spread using full-width rollers driven at a given speed, which inevitably leads to distortions. Manual correction, time-consuming and inhibiting an automated process, and/or a low product quality can be estimated as affecting the manufacturing costs by approximately 20 %. Modem machine technology, e.g. segmented and individually driven rollers might principally correct for the occurance of this effect, but lack an appropriate input of geometry-sensitive sensor systems for indication. On this background it is the objective of the proposed program to evaluate a control circuit for mechanical drive systems by taking up recent developments of fast and rather affordable sensor systems for the evaluation of the texture of textile and other flexible goods with the aim to supply the missing link of a powerful control circuit. The problem shall evaluated in the frame of the proposed project for the example of spreading tables, which form an important part of garment manufacture, but the results of the pre-competitive development shall be universally applicable to other types of machinery.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PRACE 5th Implementation Phase Project' in the context of a Horizon 2020 call.

assistant: **Objectives**

PRACE, the Partnership for Advanced Computing is the permanent pan-European High Performance Computing service providing world-class systems for world-class science. Systems at the highest performance level (Tier-0) are deployed by Germany, France, Italy and Spain providing researchers with over 11 billion core hours of compute time. HPC experts from 25 member states enabled users from academia and industry to ascertain leadership and remain competitive in the Global Race. Currently PRACE is in transition to PRACE 2, the successor of the initial five year period. The objectives of PRACE-5IP are to build on and seamlessly continue the successes of PRACE and start new innovative and collaborative activities proposed by the consortium. These include: assisting the transition to PRACE 2 including an analysis of Trans National Access; strengthening the internationally recognised PRACE brand; continuing and extend advanced training which so far provided more than 18 800 persontraining days; preparing strategies and best practices towards Exascale computing; coordinating and enhancing the operation of the multi-tier HPC systems and services; and supporting users to exploit massively parallel systems and novel architectures. A high level Service Catalogue is provided. The proven project structure will be used to achieve each of the objectives in 6 dedicated work packages. The activities are designed to increase Europe's research and innovation potential especially through: seamless and efficient Tier-0 services and a pan-European HPC ecosystem including national capabilities; promoting take-up by industry and new communities and special offers to SMEs; implementing a new flexible business model for PRACE 2; proposing strategies for deployment of leadership systems; collaboratin