RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A Strategic Roadmap Towards the Next Level of Intelligent, Sustainable and Human-Centred SMEs' under Horizon Europe.

assistant: **Concept**

Over the last ten years many efforts have been made to transfer Industry 4.0 from research to practice. Recently, great progress has been made to introduce also SMEs to the use of Industry 4.0. The next big challenge for SMEs will be to implement the dual (or twin) transformation in sense of a digital transformation towards more intelligent manufacturing, while tackling and accelerating the sustainability transformation to enhance economically, socially and environmentally sustainable processes, factories and value chains. In this project we aim to take SMEs to this next level by developing a Strategic Roadmap for making them not only intelligent but also sustainable, resilient and human-centric. This next level of SMEs will be data and intelligence-driven, thus using available data to acquire new knowledge and to apply it for optimization purposes using artificial intelligence in a secure way. Further, a great attention is paid to how manufacturing and value chains in SMEs can become more circular, green and resilient by considering ethical, human and societal values for more socio-centred factories. In this next level of SME 5.0 factories the human will play a much more important, albeit changing, role. Besides identifying emerging future work profiles and competencies of SME employees, we will develop guidelines for rendering SME workplaces in industry more inclusive and diverse and for empowering them for increased well-being and attractiveness of SME jobs. The main outcome of the project is to develop and propose a Strategic Guideline and Roadmap that will facilitate SMEs in Europe and worldwide to achieve the above mentioned goals. To expand the impact and exploitation an SME 5.0 Stakeholder & Training Network will be build. The applicability of the results and gu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Understanding the specialized function of human neurons and circuits', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Human cognition stands out from other species, but how neurons and circuits in the human brain support cognition is poorly understood. Our recent work showed that human brain holds specialized neuron types – pyramidal neurons in cortical layer 3 (L3 PNs) – with distinct properties that associate with IQ scores. In the human brain, L3 PNs form circuits with each other and another human-specialized interneuron type, double bouquet cell (DBC). These circuits might be critical for human cognition as they are selectively lost in cognitive disorders, but their function in the human brain is unknown. In addition, our data show that human L3 PNs are modulated in a distinct manner by a metabotropic glutamate receptor 3 (mGluR3), a receptor that is important in human and primate cognition. Here, I will test my prediction that cortical computation in the human brain relies on the hyperconnected network of human-specialized neuron types with strong and fast synaptic connections, that can be regulated by mGluR3 to increase computational power. This can only be achieved by novel techniques we recently applied to neurosurgery brain tissue: to study the neuronal function and synaptic properties, I will use multi-cell patch-clamp recordings of genetically-labelled L3 and DBC circuits in organotypic cultures of human brain tissue. To study the molecular mechanism of mGluR3 action, I will combine single cell RNA sequencing (patch-seq technique), and mechanistic interventions by manipulating mGluR3 pathway with viral CRISPRi/a tools. Finally, to link these results to cognition, I will collect cognitive scores and in vivo network function from the same subjects. My proposal will not only deliver valuable data on human neurons but will also provide mechanistic understanding of how human brai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Accelerating the commercialisation of a disruptive analytical technology which enables the biopharmaceutical industry to manufacture drugs faster, cheaper and with greater regulatory confidence'.

assistant: **Objectives**

The global Biologic drug [including Vaccines] market exceeds €500 bn with an annual growth of 8%. Biopharmaceutical companies need to be able to produce these new biologic drugs faster and cheaper to meet the needs of patients, regulators and the governments and insurance companies who are paying for these high cost therapies. Valitacell is an Irish SME which currently supplies this market and is a validated supplier to a growing number of market leaders including GE Healthcare & MedImmune. BIOSIM will accelerate the commercialisation of our ChemStress technology platform for this industry. Scientificallythese tests measure a cell’s performance when exposed to small molecule chemicals which simulate the stresses that the cell will experience in the scaled-up manufacturing process. When applied together they can reduce the average Cell LineDevelopment stage of drug manufacture from 16 to 6 months and reduce the average cost from €2.3million to €1.1 million.BIOSIM will support: the demonstration of ChemStress at 4 leading biopharmaceutical manufacturing sites resulting in the generation of a customer endorsed value proposition; productise the ChemStress platform for the Biopharmmaceutical industry; refinement, scale-up and validation of the product manufacture; priming the sales & marketing for product launch..ChemStress will realise €40m of end-user product sales and support 50 jobs in the 5 years following the project. ChemStress will provide EU Biomanufacturers with the opportunity to maintain their leadership position byimplementing this disruptive innovation and realizing cost reductions. ChemStress will reduce the cost of biological drugs through lower manufacturing costs so enabling EU governments to provide these drugs to EU citizens at a lower cost.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'End-user access to european rtd for the forest and wood industries sector.'.

assistant: **Objectives**

The project will create a Thematic Network linking the leading European organisations supporting the Forest and Wood industries sector. The Network will collate, assess and organise all national and EU funded RTD pertaining to the sector and create a multi-lingual electronic mechanism whereby the results of this RTD is accessible to, and understood and used by the She's that predominate in the sector. The Partner's parent networks and extensive links with the Forest-Wood industry at European, national and branch levels will be mobilised to effect the development of a far-reaching dissemination and technology transfer process. The coalescing of the Partner's networks will create an established vehicle for the creation of an electronic RTD community, dynamically linked to the Forest-Wood sector's industries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fish gill band 3-like anion exchanger - ae2' (1994-1998).

assistant: **Innovation**

The objective of the proposed study is to determine the distribution of band 3-like protein (AE2) in the gills of aquatic vertebrates. The distribution of AE2 will be determined using immunocytochemistry at the light and electron microscopic levels. A suitable antibody probe will be developed against fish erythroid band 3. I will purify the cytoplasmic fragment of band 3 protein from teleost (Oncorhynchus mykiss) red blood cells under non denaturing conditions using differential centrifugation and ion exchange and size exclusion chromatography. Antibodies will be raised against this purified peptide and once the specificity has been validated used to determine the cellular distribution of AE2 in the fish gill under different environmental conditions. In this way the function of different cell types (acid, base excreting cells) in this acid-base reguatory epithelium can be determined.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biomechanical modelling and computational imaging to identify different causes of back pain in large epidemiological studies' to be submitted under Horizon Europe.

assistant: **Abstract**

Chronic back pain is a major burden and source of disability worldwide. It is primarily attributed to different biomechanical factors, but can also have inflammatory, neurological or psychological causes. Clinical findings and conventional imaging cannot reliably distinguish different causes of back pain. In contrast, individual biomechanical models can quantify diverse (pathologic) loading patterns and thus could be used to distinguish different aetiologies of back pain, to better understand individual pathophysiology and guide preventive strategies.During my recent ERC-StG “iBack”, I developed quantitative imaging methods and deep-learning based image processing to automatically generate a fully individualized biomechanical model of the thoracolumbar spine. Simultaneously, two large-scale epidemiologic studies collected clinical and high-resolution imaging data of the spine of more than 15,000 participants so far, aiming at more than 35,000 participants by mid 2022 The high-level objective of iBack-epic is to use such novel image analysis techniques to identify different biomechanical and inflammatory causes of back pain in study participants. I will adopt and extend my recently developed deep-learning based spine labelling and segmentation algorithms to fully automatically calculate individual biomechanical, functional and morphometric parameters of the spine. In this large-scale population data, I will identify different biomechanical loading patterns, use quantitative image-based parameters to discriminate normal ageing from pathologic degeneration and identify pathological conditions that are linked to back pain or subsequent development of chronic back pain. Such a differentiation – for the first time based on quantitative image data – will allow for a better und
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'MATERIALS FOR NEXT GENERATION ALKALINE ELECTROLYZER' under Horizon 2020.

assistant: **Concept**

The aim of the NEXTAEC is development of next generation alkaline electrolyzer with a performance comparable to a good PEM electrolyzer or better without the use of noble metals.   In brief, the PEM electrolyzer can operate at high current densities (several amperes pr. cm2) due to the low internal resitstance of a thin acidic ion conducting membrane (an ion-exchange membrane). The main drawback is that the acidic system demands noble metal catalysts on both electrodes and expensive noble metal coatings on the bipolar plates and electrode backing.  The alkaline electrolyzer, does not rely on noble metals for neither catalysts nor bipolar plates, but it suffers from higher internal resistance because it does not have a thin ion conducting membrane. Despite many years of research, no research groups or companies have been able to develop a satisfactory ion-exchange membrane for the alkaline system. All attempts suffer from sigificantly lower conductivity and poor stability. The alkaline electrolyzer have so far been left with thick porous diaphragms with a significantly higher area-specific resistance, which practically limits the current density to a fraction of an ampere pr. cm2.  In the proposed project, an alkaline electroyzer will be developed around a new membrane concept. The membrane is an ion-solvating membrane. It is a polymer, which dissolves the electrolyte of the electrolyzer (aqueous potasium hydroxide). Like an ion-exchange membrane it is nonporous and it can therefore, in contrast to a porous diaphragm, be as thin as an ion exchange membrane.   The absense of noble metals makes it possible to roll out the technology in the multi GW scale that is needed in the green transition away from the dependence fossil fuels.


**Keywords:** Alkaline membrane, Alkalin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'CNIC INTERNATIONAL INCOMING FELLOWSHIPS FOR YOUNG GROUP LEADERS' in the context of a Seventh Framework call.

assistant: **Objectives**

The CNIC IIF Programme will offer a total of 24 positions during the COFUND programme life (four years) in the incoming mobility type in the area of cardiovascular research.Every year six fellowships will be offered at the level of  young group leaders: 4 Starting Fellowships (SF) and 2 Advanced Fellowships (AF). In both cases, the duration of the fellowships will be 3 years and have particular objectives both in research training and overall career development. The fellowship will include a research project prepared by the research fellow in coordination with the CNIC research department of choice, tailored to the needs of the researcher to allow him/her to reach a realistic and well-defined objective in terms of gaining new experience to strength his/her new leading independent position (leading research projects, management and organisational skills, building collaborations, student’s supervision, etc.).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of novel biomimetic engineered dental implants for periodontal ligament regeneration', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

BEDimplants project represents an innovative concept in oral implantology based on a multidisciplinary approach in periodontal regenerative medicine and tissue engineering that has the potential to significantly influence the outcome of  medical and dental therapies. The project aims to develop novel biomimetic engineered dental implants (BEDimplants) that self-promote the regeneration of periodontal ligament (PDL) and provide in a single implant therapy the adequate environment to promote specific cell lineages, such as primary human gingival fibroblast (hGF) and dental pulp stem cells (hDPSC), to integrate, differentiate and proliferate within an artificial biomimetic extracellular matrix (aECM). The utilization of natural products and biomolecules present in the native periodontal ECM such as collagen, hyaluronic acid and cell signaling molecules, BMPs and TGFbs, to be grafted onto titanium surfaces is presented as a promising approach to the development of novelty implantable devices that mimic the complexity of ECM which can be reabsorbed or degraded by the organism after their implantation. Furthermore, self-crosslinkable bioactive peptide sequences (RGD and DGEA) can be synthesized and chemically linked to those biomolecules tailoring their biofunctionality and providing a biomimetic three-dimensional aECM-g-Ti scaffold that can be implanted in the presence of the appropriate cell cocktail that fulfill all the requirements of PDL tissue engineering.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innovation Support services by EEN for Enhancing the Innovation Management Capacity of Bulgarian SMEs' in the context of a Horizon 2020 call.

assistant: **Objectives**

The EEN-BG InnoSupp project outlines the scope and services of Work Package 4 (WP4/Activity 4) of the EEN-Bulgaria Implementation Strategy. The overall project objective is to enhance the innovation management capacity of SMEs. It is broken down into the following specific objectives: (i) support the SMEs that are beneficiaries of the SME instrument in strengthening their innovation management capacity and enhancing their overall innovation efficiency throughout their project implementation; The Key Account Management (KAM) service foresees identifying gaps and needs in the innovation management domain, proposing the best match of a coach(es) and acting as mediator between the SME and innovation coach to address these gaps and needs; (ii) to enhance the innovation management capacity of Bulgarian SMEs by addressing gaps and needs with well-devised actions and measures towards increased efficiency and effectiveness of the innovation processes, and thus increased potential to benefit from the European support for research and innovation, in the scope of the ‘Enhancing Innovation Management Capacity – Innovation Expert’ services (EIMC).Within these services assessment of the innovation capacity of client SMEs will be done with the help of the IMP3rove tool. The Innovation Expert Team (IET) consists of 7 experts, 5 of whom are already licensed and trained in using the tool. The project envisages delivering 105 service packs to SMEs. All Bulgarian SMEs beneficiaries of the SME Instrument are entitled to receive the KAM services. Within the remaining service packs EIMC services will be delivered. Screening for prospective clients and beneficiaries for the EIMC services will be performed by all 12 EEN host organisations in their daily work, thus ensuring national coverage of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Microfluidics Roadmap', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The ultimate goals of this proposal are to create visions, identify technological gaps and streamline RTD activities in the field of microfluidics by elaborating a roadmap. The proposed work will bring together key players from different disciplines on a European level thereby creating the critical mass needed for the development of ambient intelligent products. Personal interviews will be held and questionnaires sent out in order to have a sound information base. Companies will be informed about the Roadmap via Internet, email, publications. The Roadmap will also be presented at conferences and fairs. It will raise awareness for this technology field and interweave intra-European activities. The roadmap will bring benefit to industry (including SMEs) as well as RTD institutions by providing a basis for strategic decisions concerning future products and necessary RTD work. It is also thought to support the European Commission in implementing priority themes of the 6th Framework Programme.Objectives:We create a technological roadmap for the field of microfluidics, one of the fastest growing branches of microtechnology. In this strongly interdisciplinary field, there currently exists a broad gap between the technological capabilities on the one side and the know-how available on the developers backend side and the awareness, needs and expectations among potential customers acting on the front end. This project aims to streamline RTD efforts with the demands of system suppliers and end users by plotting a temporal roadmap for the advances expected in microfluidics and by defining the future requirements of the customers. To ensure acceptance of the roadmap, we inquire the expertise of key European players throughout the course of the project, including the validation of re