RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Waveform-based prediction of AD-related pathology for patient diagnostics (WAVEAD)'.

assistant: **Innovation**

Due to the early AD-related pathology present in a subpopulation of idiopathic normal pressure hydrocephalus (iNPH) patients, the brains of the iNPH patients offer a unique window to evaluate events taking place during the course of AD pathology progression. Here we take advantage of our continuous access to living brain biopsies from iNPH patients and related clinical data to assess, how AD pathology affects the neuronal circuit operational properties in human brain. During the ERC consolidator project, we have discovered that pre-existing AD-related pathology alters neuronal circuit operational properties, and importantly, impairs the ablity of the network to elicit synaptic strenthening, as evaluated using stimulation protocols on multielectrode arrays (MEA).  Interestingly, a supervised machine-learning -based classifier was able to classify and predict the patient pathological status using the synaptic plasticity -induced waveforms. Here we now investigate the whether the waveforms related to glutamatergic signaling and cholinergic signaling have similar predictive value of the patient pathological status and possible clinical diagnosis and whether these readouts obtained from the ex vivo biopsies are correlated in the clinical settings using transcranial magnetic stimulations (TMS) and EEG recordings. Moreover, we probe whether the recorded TMS and EEG waveforms have the same predictive capacity in clinical settings. If succesful, these waveforms could facilitate personalized therapy or serve as a diagnostic tool for detection of early AD and thus have a significant commercialization potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Quantitative Modeling of Calcium Signaling in Vascular Smooth Muscle Nanojunctions'.

assistant: **Objectives**

The proposed work focuses on vascular smooth muscle cells, which control our veins and arteries. Their ability to contract is governed by the amount of calcium ions inside the cell. Sodium too in these cells helps regulate cellular calcium levels. In the past two decades, researchers have observed that during muscle contraction intracellular calcium concentration varies periodically. These variations are referred to as oscillations. Our research has helped establish a link between these oscillations and the health of the cell, and consequently of our cardiovascular system. In the past we have shown that such calcium ion movements in the thin smooth muscle cells spiraling around our blood vessels are controlled by complex ultra-structure of membranes within the smooth muscle cells. Since these molecular processes take place at a scale that cannot be visualized and measured by available instrumentation, we will develop quantitative computational models of calcium and sodium movement in these cells. This will greatly enhance our understanding of the basic cellular mechanisms behind these oscillations and of the machinery that enables these mechanisms. The project will use methods and concepts from pharmacology, microscopy and biophysics. The medical relevance of this research is related to the fact that all of our daily functions including movements of our limbs, beating of our hearts, regulation of our blood circulation, as well as short term memory are regulated by movements of intracellular calcium ions. Joining the researcher's expertise in quantitative modeling of ion transport in vascular smooth muscle and the partner's knowledge and understanding of ion transporters provides an ideal situation both to improve our understanding of the above mentioned mechanisms as we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'TRUSTWORTHY INTELLIGENT SYSTEM FOR REMOTE DIGITAL TOWER'.

assistant: **Objectives**

Remote digital towers (RDT) are taking place around the world to ensure efficiency and safety.  TRUSTY harnesses the power of artificial intelligence (AI) to enhance resilience, capacity, and efficiency in making significant advancements in the deployment of digital towers. The overall goal of TRUSTY is to provide adaptation in the level of transparency and explanation to enhance the trustworthiness of AI-powered decisions in the context of RDT. Through the video transmission data from RDT,  TRUSTY considers the following major tasks:1.Taxiway monitoring (i.e., bird hazard, presence of a drone, autonomous vehicle monitoring, human intrusion, etc.).2.Runway monitoring (approach and landing) misalignment warning and the corresponding explanation.To deliver trustworthiness in an AI-powered intelligent system several approaches are considered: •‘Self-explainable and Self-learning’ system for critical decision-making•‘Transparent ML’ models incorporating interpretability, fairness, and accountability•‘Interactive data visualization and HMI dashboard’ for smart and efficient decision support•‘Adaptive level of explanation’ regarding the user's cognitive state.•“Human-centric AI” enhances the trustworthiness of AI-powered systems.•“Human-AI teaming” to consider users’ feedback to insure some computation flexibility and the users’ acceptability.To achieve the goal, TRUSTY will rely on the SotA developments in interactive data visualization, and user-centric explanation and on recent technological improvements in accuracy, robustness, interpretability, fairness, and accountability. We will apply information visualization techniques like visual analytics, data-driven storytelling, and immersive analytics in human-machine interactions (HMI). Thus, this project is at the crossroad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Development of late transition metalloenzymes and metallo-DNAzymes for higly efficient catalytic processes'.

assistant: **Objectives**

The proposal is to move the group of Dr. Paul Kamer to the School of Chemistry, University of St. Andrews to carry out an exciting range of projects related to sustainable development. Waste-free chemical processes are a must for a sustainable society. In nature, enzymes enable the atom economic synthesis of numerous natural products, but there are no enzymes for the synthesis of the many pharmaceuticals, agrochemicals and fine-chemicals that our society needs. To solve this problem, we seek a paradigm shift in catalysis research by developing transition metal containing artificial enzymes" for catalytic transformations towards industrial products.We propose a "de novo" design of transition metalloenzymes, using molecular recognition properties of biomolecules to develop (late) transition-metalloenzymes by functionalising oligonucleotides and proteins with phosphino ligands and binding them to late transition metals. Adjusting the structures of the biomolecule and the phosphine ligand will optimise the catalytic performance of these artificial enzymes. Artificial "metallo-DNAzymes" can be developed by complex formation of transition metal prosthetic groups and DNA aptamers as "apo-DNAzyme", starting from large aptamer libraries. The search for efficient "metallo-DNAzymes" will be aided by complex formation with transition state analogues, starting from large dynamic combinatorial libraries. We will create a new class of highly selective catalysts for demanding transformations, like CO insertion, alkene insertion and (asymmetric) C-C bond forming reactions. The biopolymer part will induce the proper substrate orientation to the metal centre. Encapsulating substrates by these "synthetic biopolymers" will then be exploited to achieve clean conversion of unfunctionalised mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Function of calcium in photosynthetic water oxidation and tyrosine redox kinetics in photosystem II' in the context of a Sixth Framework call.

assistant: **Objectives**

Photosynthetic water oxidation that occurs in photosystem II (PSII) is one of the key processes in photosynthesis. Understanding the reactions in PSII on molecular and electronic level is of fundamental interest for photosynthesis research and also important for the development of artificial photosystems for energy production. A redox active tyrosine (YZ) is known to be essential for the electron transfer reactions that ultimately lead to water oxidation in PSII and it has also been suggested that this amino acid is directly involved in catalysing water oxidation. The mechanism for YZ redox reactions, and specifically the mechanism for proton coupled redox reactions, is however unresolved. The mechanism for YZ oxidation is part of this proposal.   The first crystallographic data on an atomic level that was recently published suggests that a calcium (Ca) ion is the metal closest to YZ and that this Ca ion is an integral part of the catalytic water oxidation site. Clearly the role of Ca is at the heart of the mechanism for YZ redox chemistry as well as for the catalytic water-splitting activity in PSII. To find the impact of Ca on YZ redox kinetics as well as on the water oxidation activity in PSII I will use Ca depleted PSII samples. On this material I will perform a complete study of the effect of pH and temperature on YZ redox kinetics to determine the mechanism for YZ oxidation using time resolved absorption measurements.   I have previously shown that the pH-dependence of tyrosine oxidation can be used for mechanistic discrimination for proton coupled electron transfer reactions in synthetic tyrosine model complexes. In parallel I will examine the redox events occurring in the water oxidising complex using advanced EPR to determine the functional role of Ca for water
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Targeting cancer with multi-engineered selenium nanoparticles (SeNPs): Development of a biocompatible nanocomposite for targeted gene therapy in BRAF-mutated resistant melanoma.'.

assistant: **Innovation**

Nanotechnology has grown at an exponential rate in the last decade, finding a large application in the biomedical field. Nanoparticles are emerging as effective drug delivery tools, since they overcome most limitations of free therapeutics - while offering a series of physical/chemical advantages. Among engineered nanomaterials, selenium nanoparticles (SeNPs) have shown a growing potential as a therapeutic platform since they offer both the properties of selenium (Se) and the ones of a nanoscale system. SUNSET project aims is to design and develop a hydrogel-based nanocomposite containing multi-functionalised SeNPs, to use as an effective nanoplatform for cancer gene therapy. The designed system will be evaluated in resistant melanoma, specifically BRAF mutated lesions, which represent 66% of the cancer cases and are those that show resistance to currently available therapies, causing most cancer deaths. Here, the synthesis of SeNPs is followed by surface functionalisation with a specific small interfering RNA (siRNA) and their embedding in the polymeric phase. All the materials will be synthesised through green chemistry routes, to guarantee a low environmental impact of the procedure and its scalability and reproducibility. The anticancer activity of the nanocomposite will be evaluated both in vitro and in vivo. Overall, the combination of RNAi technology, nanomedicine and biocompatible materials – selenium and natural hydrogels – will be useful to gain a more efficient therapy, overcoming the main current challenges in the care of resistant melanomas. Moreover, the simplicity of the fabrication and the possibility to scale up the procedure, make the proposed system possibly attractive for clinical applications, promoting European Scientific Excellence. Lastly, I will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Politics of the Periphery’ in Urban Latin America: Reconceptualising Politics from the Margins', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Existing theory on how residents of urban peripheries engage with the state is largely state-centric. Political anthropology and urban studies have generally conceptualised periphery-state engagements as non-standard citizenship, informal politics, or protest. Such conceptualisations risk contributing to inequality, as they understand the politics of marginalised city residents as less than or only as anti formal state policies and citizenship regimes.POPULAR will counter this disparity by developing a theory of politics that reconceptualises periphery-state engagements from the vantage point of the periphery. This reconceptualisation will connect the concepts and practices residents use as part of their political praxis to recent anthropological debates that pluralise and decentre our understandings of politics. It will approach the variety of practices inherent in periphery-state engagements as a politics of the periphery, a diverse politics in its own right and on its own terms that emerges from local modes of agency, subjectivities, and the social configurations of urban populations which are marginalised on a daily basis. POPULAR will ethnographically study the politics of the periphery in three domains: governance, electoral politics, and activism. It will compare these politics in low-income neighbourhoods in three cities in Latin AmericaMedelln (Colombia), Santiago de Cuba (Cuba), and Recife (Brazil)a region known for its urban poverty, popular mobilisations, and the diversity of government engagements with marginalised populations. The three city governments can be characterised as, respectively, neoliberal capitalist, socialist  and moderately neoliberal with a socialist legacy. Each case represents a distinct approach towards the urban periphery. Through a ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Policies for sustaining environments and livelihoods in mountain areas' under Fourth Framework.

assistant: **Concept**

* The main intention of the research is to encourage the uses of environmental resources (particularly vegetation, soils and water) for the benefit of all people.* A second intention is to improve the understanding of past and present environmental deterioration. We will study the changes which may be a consequence of farming, pollution from towns and mines and the frequency of natural hazards (such as floods, landslides and earthquakes).* We want to see how people make use of the environment in order to live, and how they maintain its quality.* The recent changes in land use will be studied to discover patterns of environmental change which may be associated with such use and whether community and regional inequalities have increased.* Sector policies which influence these changes will be investigated to see if they can be improved for the benefit of all.Expected Outcome* Identification of human use factors underlying positive and negative environmental changes.* Accurate data on how environments have been affected by natural and environmental change factors.* Natural hazards and related coping strategy identification.* High quality findings on policy options.* Delineation of institutional structures coping with environmental changes and stresses.* Identification of resource uses associated with positive and negative environmental change.* Assessment of impact of sector policies at a community and regional level.* Identification of intensive resource uses and their impact on households and environment.The study will be conducted in the Quebrada de Humahuaca (North-Western Argentina), the central Tarija valleys (Southern Bolivia) and the Colca and Puquina river basins (Southern Peru). A Geographical Information System (GIS) will be established for each study area to sho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Unravelling the Genomic Targets of Drugs Using High-Throughput Sequencing'.

assistant: **Innovation**

This proposal is centred on the development of small molecule probes derived from DNA damaging agents to identify their genomic targets using a novel unbiased approach. Although, several genotoxic drugs have been used for decades to treat cancers, the exact mechanisms by which they operate are not fully understood. It is established that these compounds interfere with the processes of transcription and replication, thereby promoting genomic instability and cell death. However, there is as yet no genome-wide map of the exact location of sites that are putative targets for these drugs in vivo. This information is critical to understand and rationalize cellular responses to genotoxic agents. Here, we propose to develop an innovative discovery- based methodology that will combine click chemistry in situ, affinity pull-down techniques and high throughput DNA sequencing (Drug-Seq), to identify the genomic interactome of DNA damaging drugs in order to elucidate their cellular activity at the molecular level. Two independent lines of enquiry will be followed. Firstly, we will establish the genomic interacting landscape of landmark drugs including etoposide, camptothecin and cisplatin using Drug-Seq. Secondly, we will perform regular chromatin immuno- precipitation sequencing (ChIP-Seq) of selected proteins linked to the cellular response of interest to validate Drug-Seq and further identify druggable genomic sites. An important aim of this proposal is to establish a universal methodology to decipher small molecule/genome interactions in vivo that trigger a particular response in disease-relevant models. We also seek to interrogate the role of chromatin in regulating drug/genome interactions and to define whether it is possible to act on the epigenome to modulate the activity an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Unified, holistic medical data collection and analysis platform' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Due to the new EU Medical Device Regulations, the medical device industry needs to continuously obtain more and more accurate clinical data. However, due to limited resources, high costs and long clinical trial durations this data may not be obtained, resulting in (temporary) removal of proven medical devices from the EU market, while new devices may only be available in the EU with significant delay. Hence, the industry is desperately searching for solutions to accurately document clinical evidence of existing and new treatment options in a time and cost-efficient way. We are Raylytic, a German SME from Leipzig, specialised in clinical trials and radiographic image analysis. Since 3 years we have identified the described new business opportunity and started developing UNITY: a unique medical data collection and analysis platform that integrates traditional data collection (clinical data, patient outcome, lab data) with medical image analysis. Thanks to our advances in computer vision and medical image analysis technology, UNITY will be the next state-of-the-art solution, tapping into the clinical diagnostics, imaging software and pharmaceutical trials markets. The impact of UNITY for our clinical trial clients is a cost reduction of up to 40% for the execution of clinical trials. We have identified a favourable regulatory and reimbursement pathway. With the described project we intend to prepare UNITY for FDA and CE market clearance and subsequent successful market launch by 2022. After the project and upon regulatory approval, we intend to directly follow up and sell UNITY to hospitals as a hardware-vendor independent computer-aided diagnosis solution, as they will be using the platform already in clinical trials. Through this project (estimated ROI of 14.2), the comp