RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'NAD synthesizing enzyme NMNAT1 as a fine regulator of the survival of neuron', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

We propose here to investigate the role of the nuclear NAD-synthesising enzyme nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1) as a fine regulator of neuron survival, aiming at identifying new targets for intervention in age-associated pathological conditions of the nervous system. NAD synthesis is central to neuron maintenance and to the action of enzymes such as sirtuins (SIRTs), poly(ADP-ribose)polymerases (PARPs), NAD glycohydrolases and ADP-ribose cyclases, involved, via gene transcription or by signalling mechanisms, in the regulation of cell and organism lifespan, in the response of neurons to stress and in protection in models of neurodegenerative diseases. NMNAT’s involvement in these processes is rapidly emerging but has not been investigated in detail. Our preliminary studies indicate that nuclear isozyme NMNAT1 is required for neuron maintenance. Building on this, here we will test the hypothesis that NMNAT1 controls neuron survival by regulating the activity of downstream enzyme SIRT1. This project is based on the unique availability to the host laboratory of Nmnat1 genetically modified mice and on the perfect match between the expertise of the host laboratory and the complementary skills of the IEF applicant, Dr Jessica De Ingeniis, a talented researcher who has received extensive training in NAD biochemistry and metabolomics in Italy and USA. This study, which can only be accomplished by combining these skills of the IEF fellow with the mouse genetics and neurobiology expertise of the supervisor, will serve two crucial purposes. It will provide vital insights into the mechanisms of neuronal survival and the role of nuclear NAD biosynthesis, constituting a fundamental prelude to the development of specific inhibitors and activators of NMNAT1 wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Automated spectographic egg-inspection system for the production of poultry vaccines' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Today, the inspection of eggs during the production of poultry vaccines is done manually. Eggs for poultry vaccine production are candled all way through their embryonic development. Candlers" try to identify the right time for harvesting the vaccines from the egg and remove non-viable eggs on the basis of their internal color, the embryonic development stage, the embryos location in the egg, possible damages of the embryo etc. Such techniques are difficult and unreliable although corresponding experts are well trained and experienced in conducting this work. Experiences show that, since the work is extremely monotonous, the error rate is in the range of 5-15%. Additionally, the time required for inspecting a single egg is with approx. 15 seconds comparatively high and pose a bottle neck for increasing productivity in poultry vaccine production. The objective of this project is the development of an automated non-invasive optical method for the detection of infected, rotten and dead eggs as well as for the determination of the exact harvesting time in poultry vaccine production."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High Efficiency Fuel Pumping' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The concept of this project is the TRL 6 demonstration of a high speed, light weight, large capacity variable displacement piston pump for medium and large aero-engine fuel system applications, capable of high efficiency performance at fuel flows of up to 40,000 pounds per hour and pressures up to 2200 pounds per square inch.Piston pumps currently find application on the fuel systems of small and medium engines. This project aims to build on AEC’s pedigree and inherent high reliability in this market while addressing the speed limitations of the current piston pumps. By increasing the maximum speed capability the large flow output can be achieved with a smaller displacement pump, to meet the required mass target of 50 lbs. Higher speed requires a greatly increased duty, a term used to compare the relative levels of stress and velocities of the pumping elements.This higher duty performance will be achieved through application of modern materials, coatings, manufacturing technologies and advanced analysis methods. The pump shall be designed to retain the current high mean time before failure of 300,000 hours, with an overhaul life of 30,000 hours.The project is split into eight work packages, with the overall aim being to design and manufacture a variety of options for the high duty pump’s internal components to be tested within a flexible demonstrator vehicle. The optimum combination will then be identified and subjected to further testing to demonstrate TRL6, resulting in a final design proposal for a large engine application.AEC has in-house pump design, manufacture and performance and environmental test capability.  However, this technology programme will require external capabilities relating to specific design and manufacturing processes and capabilities, and materi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Medical Applications of Rapid Prototyping' in the context of a Fourth Framework call.

assistant: **Objectives**

Data collected from common medical scanning systems will be transferred onto computers and rendered as images to be processed into 3D models, then analysed by an ad hoc expert system in terms of unique definition and intervention requirements, and submitted to simulated operational tests (structural, mechanical, thermal, etc...); afterwards, models will be transferred to rapid production using previously selected materials (according to their bio-compatibility): finally, quality control will be performed on products by functional tests and measurements. Data collected from common medical scanning systems will be transferred onto computers and rendered as images to be processed into 3D models, then analysed by an ad hoc expert system in terms of unique definition and intervention requirements, and submitted to simulated operational tests (structural, mechanical, thermal, etc...); afterwards, models will be transferred to rapid production using previously selected materials (according to their bio-compatibility): finally, quality control will be performed on products by functional tests and measurements. Data collected from common medical scanning systems will be transferred onto computers and rendered as images to be processed into 3D models, then analysed by an ad hoc expert system in terms of unique definition and intervention requirements, and submitted to simulated operational tests (structural, mechanical, thermal, etc...); afterwards, models will be transferred to rapid production using previously selected materials (according to their bio-compatibility): finally, quality control will be performed on products by functional tests and measurements. Data collected from common medical scanning systems will be transferred onto computers and rendered as images to be proc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Advanced software system for energy management of chp plants' in the context of a Fifth Framework call.

assistant: **Objectives**

The project aims at developing intelligent management and regulation system for CHP pants, with characteristics of artificial intelligence and auto-learning, able to manage a plant of co-generation in a dynamic way in relation to internal and external parameters to the plant such as:-Instantaneous pattern of electricity and heat demand on users' side-characteristics of the pricing system of the country in which the plant is settled -characteristics of plant operation in relationship with maintenance requirements The tool will be expressly conceived to interact with the users through simple and easily available input data but will contain a high level of sophistication inside, and will be able to retrieve autonomously updated information (e.g. through Internet) about prices, tariffs, etc; such a system can possibly integrate techniques of artificial intelligence (e.g. to identify complex operation patterns of the plant through simple operating data), DSS and expert systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Development of innovative biotic symbiosis for plastic biodegradation and synthesis to solve their end of life challenges in the agriculture and food industries'.

assistant: **Concept**

RECOVER is a disruptive RIA proposal built upon the actual needs to solve the contamination of agro-fields with non-biodegradable agro-plastics as well as to improve municipal waste handling by decreasing drastically the packaging fraction going to unsustainable waste management routes.We intend to reach our ambitious objectives applying biotech solutions that will include symbiotic bioprocesses between previously reported high powered microorganisms through microbiotic systems vectored by several insect species. Indeed, one of the main innovations in our proposal is the combination of endogenous and exogenous microorganisms and their inoculation on insects. This will allow achieving higher levels of biodegradation and direct conversion (at the same time) of agri-food plastic wastes in insect by-products such as chitin, that can be converted in chitosan (high value as bioplastics raw materials and other interesting industrial applications due to anti-microbial activity) that will be used in active packaging, enhanced mulching films and biofertilizers applications.RECOVER will help providing novel biotechnological solutions applying microorganisms, enzymes and insects to degrade conventional plastic packaging and agricultural films waste streams but also result in new feedstocks for the bio-based industries. The process will be optimized and performed either ex-situ in composting reactors (preferred route for non-recyclable plastics from municipal solid waste or for agricultural films that can be collected easily) or in-situ in the case of bioremediating soil pollution, by e.g. mulching films, further contributing to the long-term removal of non-biodegradable polymers from the environment. In addition, RECOVER can solve the microplastics pollution at the level of both in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Metabolic Profiling of the Vaginal Microbiome for Reproductive Health'.

assistant: **Objectives**

There is ever increasing evidence that the vaginal microbiome plays an important role in reproductive health. Studies have shown that dysbiotic states can culminate in bacterial vaginosis, urinary tract infections and premature birth. Although the microbiome is usually characterised by 16S rRNA sequencing, the methodology is time consuming and expensive. Here we describe the development of a desorption ionisation mass spectrometry (DESI-MS) based technique which characterises microbial community structures based upon metabolomic analysis. The technique has been successfully demonstrated for a range of applications and here we describe its commercial development as a diagnostic tool, firstly, for assessing the potential success rates of in vitro fertilisation treatments and, secondly, for stratifying patients at higher risk of pre-term birth. During the first 12 months of the project the technology will be assessed using a unique sample set collected as part of two longitudinal cohort studies. During the later stages a thorough market assessment will be performed to identify the addressable demand and to evaluate market competitors. It is envisioned that this information will allow an in depth business case, including our current intellectual property position, to be written, from which further funding can be obtained for the eventual creation of a spin out company.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Developing a new monitoring protocol for lead in drinking water' (1994-1998).

assistant: **Concept**

The EC Drinking Water Directive currently under developmend will follow the World Health Organisation recommendation to adopt 10 ug/L of Pb as the parametric value for lead in drinking water. At the moment the parametric value for this element is 50 ug/L. Lead in drinking water originates mainly from service pipes and internal plumbing. The actual exposure of consumers to lead depends strongly on the plumbing materials used, water composition (e.g. pH, alkalinity) and on the contact (or stagnation) time of the water and the plumbing system. The last varies according to consumer's behaviour (water use pattern). Therefore, the new EC DWP states that statutory monitoring of lead should take place at the consumer's tap and should be based on a sample 'representative of that consumed by man'.The overall objective of this project is to develop and validate a monitoring protocol for lead in drinking water which meets the demands of being:1. representative of that consumed by man;2. accurate;3. practical; and4. cost effective.Three possibly successful sampling procedures have been selected. These sampling procedures are being tested throughout Europe. The results show correlations with the reference method. All laboratories involved in the test showed sufficient analytical capability.The monitoring protocol consists of sampling at the consumer's tap and pre-treatment and analysis at a laboratory. To address these different aspects the work programme is divided into four work packages:1. design of a new sampling procedure: based on theories on lead release to drinking water, statistical assessment of water use at the tap and experience with sampling procedure currently in practice, a new procedure will be developed;2. assessment of analytical capabilities: the analytical accurac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fast-tracking ROOTStock breeding in olive' under Horizon 2020.

assistant: **Concept**

Adaptation to environmental conditions is key to maximise crop productivity under limited water and other stresses related to climate impacts. Combining stress resistance with desired agronomic characteristics through regular plant breeding in fruit trees such as olive requires a huge amount of time and resources and might not be feasible by just using the current available genetic pool. However, the use of rootstocks could overcome some of these stresses that are challenging tree crops worldwide and allow to unlock the genetic potential of wild relatives of olive. The objective of FROlive is to speed up the rootstock breeding process in olive trees by developing accurate, fast phenotyping and grafting methodologies for the early selection of new olive rootstocks, in first instance for drought resistance. This will be done by using techniques that are known to the applicant due to his background in plant breeding and disease resistance screening and analysis techniques, in collaboration with the hosting group, which has a strong track record in the study of olive germplasm resources, genetics and breeding, as well as proven ability to train students and scientists. The approach and techniques used in FROlive will allow a faster development of rootstocks resilient to new challenging environments and pests, therefore reducing the environmental impact and future proofing our olive orchards. The training will allow the applicant to be trained as a fruit tree breeder, increasing the capability in this research area. The project presents a multidisciplinary approach as it brings together plant propagation, germplasm resources, genetics and statistics. It also represents a collaboration of five different partners, the University of Córdoba, the Swedish University of Agricultur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Selecting, Creating and Modifying Embryos: the ethics of new reproductive genetic technologies'.

assistant: **Innovation**

For over three decades reproductive technologies have been available which allow parents to select between embryos based on their genetic makeup. Soon two novel ways of influencing a child’s genome could also become available. In 2013, personal genomics company 23andMe received a patent to a technology called ‘Gamete Donor Selection Based on Genetic Calculations.’ This technology would allow individuals accessing assisted reproductive services to choose between sperm or egg donors based on the likelihood of the embryos having a particular genetic makeup. Technologies like this allow parents to create rather than select embryos with desirable genetic characteristics. In addition genetic engineering technologies continue to improve. The recently developed ‘CRISPR’ technique provides a more precise way of altering the genome than previous methods, and is the first modification technology with real potential to be used on human embryos. Technologies like this may allow parents to modify the genetic material of existing embryos. These developments are seen by some as raising very serious ethical worries, and by others as promising to promote human flourishing. Therefore there is an urgent need to give them systematic ethical scrutiny. If elected to this fellowship I will conduct a rigorous review of embryo creation, modification and section technologies and their ethical, political and philosophical implications. Built on an in-depth understanding of the science behind these technologies, my project will encompass an analysis of relevant philosophical and ethical issues, before delivering practical policy suggestions. This project will be the first extensive overview of the ethics of embryo creation technologies, the specific ethical issues raised by the CRISPR technique, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Interplay between High-Temperature Superconductivity, Magnetism and Composition in Doped Cuprates'.

assistant: **Innovation**

The origin of high-temperature (high-T) superconductivity (SC) is one of the greatest unsolved problems in physics. The solution could potentially lead to room temperature SC with immense technological benefits. There is ample evidence that microscopic magnetic correlations and dynamics are coupled to high-T SC, but a true understanding remains. The proposed research focusses on the effect of dopants on magnetic and SC properties of La2-xSrxCuO4 (LSCO) cuprates. The main research question is: does the SC mechanism has its origin in the magnetic properties of the material? This will be tackled in three ways: 1) The applicant will determine if the new theoretical prediction of the SC transition temperature increase with very small impurity content is justified for LSCO. This whole new effect will strengthen the case for magnetism-induced SC. 2) The applicant will study the low-temperature magnetic phase of LSCO when SC is fully suppressed by doping and field to provide new insights into the nature of intrinsic magnetic tendencies of LSCO. 3) The applicant will synthesize single crystals of completely new cuprates by replacing Sr by Sn, Zr and Ga to study how the ionic radii affect the magnetism-SC interplay. The project involves crystal synthesis, XRD, VSM and transport measurements and has a strong focus on elastic and inelastic neutron scattering experiments and data analysis. The applicant’s physics background and PhD in materials chemistry provide a strong basis for the experiments. The interdisciplinary nature of UCPH creates the ideal environment: the main supervisor Prof. Lefmann is an expert in neutron scattering with decades of experience, has all necessary physical characterization equipment and is a well-appreciated academic teacher. All relevant chemistry infr