RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Control of flowering time in arabidopsis thaliana - determination of spatial and temporal requirements for fca activity identification of molecular partners' (1994-1998).

assistant: **Innovation**

Research objectives and content The floral transition is a fundamental developmental switch in the plant life cycb. fca Arabidopsis mutantsexihibit delayed flowering under inductive lon8 days. The FCA protein contains two RNA-binding domains and a putative WW domain which could mediate protein-protein interaction. The FCA protein is likely to function as a post-transcnptional regulator. The research project will address two questions. Firstly, when and where the FCA protein is required in the plant to control the floral transition ? The bacteriophage loxP/Cie site-specific recombination system will be use to generate FCA +GUS- sectors in anfca GUS+ background. In silu staining of GUS activity in plants of wild-type phenotype will indicate where the FCA function is precisely required. In parrallel, a chimeric FCA-GRE protein of which expression will be triggered at specific stages of plant development by watering plants with steroid will also be constructed. Secondly, to which molecular partners does the FCA protein bind in vivo ? We plan to identify RNA sequence motifs using the SELEX procedure that have high affinity for the FCA protein. Two-hybrid studies will put forward proteins that specifically interact with the FCA protein. Training content (objective, benefit and expected impact) The proposed experiments involve a large variety of molecular biological, plant genetic and plant cell biological work, most of which I have no experience with. For me working in Dr. Dean's lab would mean an excellent chance to work in a laboratory which has got a leading role in Arabidopsis research. It will give me the opportunity to interact with the many scientists of the John Innes Centre. A post doctoral fellowship in Dr. Dean's lab will greatly improve my intellectual and technic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Metabolic Dynamics in Colorectal Cancer' (MDCRC) targeting Horizon 2020.

assistant: **Abstract**

Metabolic reprogramming has recently emerged as a key hallmark of cancer. Despite many efforts made to identify metabolic properties of cancer cells, there is a complete lack of understanding of the specific steps in the tumorigenic process when this metabolic rewiring occurs and its biological consequences. In this regard, our previous work has revealed a critical role of glucose metabolism in driving tumor initiation, in particular in the intestine. Importantly, recent studies have demonstrated that intestinal stem cells (ISCs) are the cell of origin of colorectal cancer (CRC), and our preliminary data suggests that glucose metabolism could be important for ISC activity. Based on these findings, we propose to study the specific metabolic properties of intestinal stem cells (ISCs) and its relevance in stem cell dynamics and CRC initiation and progression. Specifically, we will develop three aims:1. To analyze the role of metabolic reprogramming in ISCs and its contribution to CRC by employing a combination of genetic, metabolic and imaging techniques.2. To study the metabolic evolution of CRC.  In this aim, by using patient-derived xenografts and intestinal organoids expressing a genetically encoded metabolic reporter, we will analyze glucose metabolism in vivo at a single cell level to define step-wise the role of metabolic reprogramming in CRC progression. All together, the successful completion of this proposal will identify the specific cells and steps during CRC where glucose metabolism is functionally relevant and the underlying molecular mechanisms, thus expanding our view of metabolic reprogramming beyond the idea of being just an adaptation to increased proliferation. Importantly, the results derived from this project could potentially be used to improve curre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Decoding hidden Structural Variants in unsolved Rare Genomic Diseases' (DETECT-SV-RD).

assistant: **Concept**

Rare Genomic Diseases (RGDs) affect >200 million individuals globally, however less than half of patients receive a molecular diagnosis, forcing millions into year-long diagnostic odysseys, and limiting the possibilities for personalized care. New studies suggest that forms of DNA mutation affecting many base pairs of at once, so-called 'Structural Variations' (SVs) and 'Short Tandem Repeats' (STRs) may play a dominant role in the biological underpinnings of many undiagnosed RGDs. The DETECT-SV-RD project will  utilise one of the largest-to-date RD-patient datasets, containing >1,400 genomes obtained by latest long-read sequencing and optical genome mapping technologies, to identify the full spectrum of SVs and better understand their impact on disease formation. To achieve this, a new computational workflow for detecting SVs will be developed, which will have a special focus on mutations that occur in the most complex, repeat-rich regions of the human genome. Using these technological advances, SVs and STRs will be identified across all patients, and carefully characterized in terms of their rarity, the properties of their breakpoints and likely biological formation mechanisms. Lastly, these insights will be combined with orthogonal 'omics' and phenotypic data to gain new insights into the underlying biology of rare diseases. In collaboration with the diagnostic department at Radboudumc, new genetic tests for SVs and STRs will finally be implemented to improve patient care. The project will, for the first time, assess the effect of SVs and STRs even in complex genomic regions comprehensively and provide an estimate for their involvement in the formation of RDs in general, as well as likely a better understanding of previously undiagnosed RDs. The project will thus cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Energy Efficient Transprecision Techniques for Linear Solver'.

assistant: **Objectives**

All computations that use floating-point arithmetic are built on the fundamental assumption that the computation is meaningful when employing only a limited precision. The required precision typically varies throughout the computation and depends on the actual represented values. Many computations use too many bits of precision, which reduces performance and increases energy consumption. The Entrans project aims to utilize the optimal precision during a computation without loss of accuracy, which will result in higher execution speed and lower energy consumption. This idea, dubbed transprecision computing, requires novel results in numerical analysis and runtime decision making to adapt the precision of a computation on the fly.The Fellow, JunKyu Lee, is an expert in numerical analysis and will collaborate with the research group of Dr Hans Vandierendonck at Queen’s University Belfast, who are experts in high-performance and parallel computing. The Fellow will collaborate with experts in runtime systems software and with experts in computer architecture. This unique collaboration and combination of skill sets is crucial to embed dynamic, runtime behavior in numerical algorithms.This ambitious research project, in conjunction with formal training and bespoke mentoring will enhance the Fellow’s academic profile, research experience, and breadth of skill set in numerical analysis and high-performance computing. Providing fundamental insights in the runtime variation of precision requirements of numerical algorithms will improve their execution speed and energy-efficiency, but will also lay the foundation for the development of novel algorithms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Physical modelling of drilling fluid filter cake failure phenomena' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content Filter cakes formed from drilling fluids invading the hydrocarbon reservoir are inherently damaging. The cakes contain swollen polymer gel and particulates (weighting agents and drill solids). EC Joule 3 Programme JOF3CT950020 'Environmentally-acceptable Polymer-based Wellbore Fluids for Optimising Reservoir Productivity', joining Schlumberger Cambridge Research, Institut Frangais du Pitrole and Statoil as partners, is defining key experimental parameters to improve filter cake clean up. The proposed research will complement the EC/Joule project by developing a physical model for filter cake removal. The model will explain observed behaviour and define areas for further experimental study. Analytical models for filter cake deformation and adhesion to the rock substrate will be identified and developed. Complementing these, meso-scale numeric modelling will be applied. Training content (objective, benefit and expected impact) I will extend expertise in applied physics to an oilfield application. New knowledge will be gained in polymer gel properties, flow through porous media, and meso-scale modelling. Experience will be gained in industrial research and the petroleum industry. Links with industry / industrial relevance (22) A physical model of filter cake removal would have direct impact on petroleum production and would lead to products/services to reduce the cost of retrieving oil. Such a model will also enhance the precision for estimation of hydrocarbon production from a well and change preferred practice to optimise well production.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Networked cultures - negotiating cultural difference in contested spaces'.

assistant: **Innovation**

Departing from sites of geopolitical conflict and social confrontation, the Networked Cultures project aims to reconsider the cultural transformations under way in Europe through examining the potentials and effects of networked spatial practices. The project seeks to extend current debates of architectural and spatial planning by addressing the emergence of new forms of urban engagement, by re-evaluating the relationship between space and conflict and by establishing trajectories of an architectural culture geared towards network formation. As the emergent cultural networks start to grow and interface with the more dominant cultural economies of globalisation, there is the immanent danger that they are being naturalised, homogenised and translated into stable entities, i.e. into simple forms which tell us nothing about how links and relations are being made between different cultures. The proposed research will examine how networks may resist these dynamics and how they can retain their innovative powers by transforming into something else. In doing so, the research employs a variety of strands along which the project itself can develop within networks of exchange and intervention. First, it brings art and architecture projects together with video-interviews, photographic and film material produced in contested geographic regions during the initial Marie Curie Intra-European Fellowship for a documentary film to be shown in galleries, cinemas and other public venues. Second, it installs research platforms" in museums, galleries and other public art/cultural institutions to critically engage a variety of knowledge producers in a debate on the transformation of emerging networked art/urban practices. Third, it widens the scope of the initial Marie Curie fellowship by link
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A process for the assessment of scientific support for claims on foods' under Fifth Framework.

assistant: **Concept**

A network will be set up to critically assess the criteria currently used, and to determine those, which are needed, for the scientific substantiation of health-related claims on foods. This project will build upon the FUFOSEconclusions that claims for enhanced function and reduced risk of disease should be based on studies using identified, characterised and validated markers. Initially, three Individual Theme Groups (Its) will focus on three diverse physiological areas and a fourth ITG will review the existing scientific criteria in different countries. This initial selection of the criteria will be tested and broadened by four Its who will consider four different areas. A Consensus Group will then identify the gold standard principles for assessing the scientific support for claims that will assist those making and regulating claims, and will also increase their credibility for consumers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High Attenuation Recycling Materials as sustainable barriers for waste disposal sites' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The need to minimize the amount and foster the safe treatment of waste, and thereby reduce the risk of contamination; emphasises the importance of promoting technologies which are environmentally sound with products suitable for re-use/recycling. This project establishes a laboratory experimental study to determine the performance of clay mixed with construction and biomass plant waste (fine recycled aggregates, FRA, and/or biomass bottom ashes, BBA) as materials for the enhanced attenuation of contaminants in landfill leachate. The aim is to (1) evaluate the contaminant attenuation capacity of these mixtures for different conditions, (2) develop design guidelines to construct barriers for waste containment systems and similar applications, and (3) interpret their performance using numerical modelling tools. Column experiments where landfill leachate is passed through different waste:clay mixtures will be run in a state-of-the-art centrifuge facility which simulates realistic times, pressures and temperatures of landfill field conditions. The geochemistry of the column pore water and material residues after permeation with leachate will be examined to deduce the processes responsible for pollutant removal and retention. After permeation with landfill leachate, the effects of exposure of these barriers to an aggressive acid environment, rainfall infiltration and rising water table will be studied. The concept will be applicable for barrier design at other waste disposal facilities. The results will provide a novel and timely improvement which addresses the problem of managing the vast amounts of industrial residues such as FRA and BBA. Instead of disposal these will be re-used/recycled as an additive in host clay for building contaminant barriers, thus also conserving na
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Development of a fabrication and quality assurance facility for the drift- tubes of the muon chambers of the atlas experiment'.

assistant: **Innovation**

Research objectives and content High-momentum final-state muons are amongst the most promising and robust signatures of physics at LHC. To exploit this potential, the ATLAS Collaboration has designed a high-resolution muon spectrometer. The basic detection elements of the muon chambers are aluminium tubes of a typical single wire resolution of 80 llm. The aim of the proposed project is to setup the facilities for the fabrication of the drift tubes and the assurance of their quality. The required single wire resolution commensurate a high precision mechanical construction process of the drift tubes. During or directly after the tube fabrication extensive quality assurance is required, which will verify the wire location and tension, leak rate and proper operation of each tube. Training content (objective, benefit and expected impact) The proposed project will give the opportunity to the scientific staff, the technicians and the under- post- graduate students to be trained on advanced technological techniques. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Processes of vertical exchange in shelf seas' (PROVESS) under Fourth Framework.

assistant: **Objectives**

PROVESS is an interdisciplinary study of the vertical fluxes of properties through the water column and the surface and bottom boundaries. Its objectives are to:A) Improve understanding and quantification of vertical exchange processes in the water column, particularly in the surface and benthic boundary layers and across the pycnocline;B) Explore mechanisms of physical-biological coupling in which vertical exchanges and turbulence significantly affect the environmental conditions experienced by biota;C) Apply innovative technologies to the measurement of physical microstructure features and phenomena, in particular turbulence properties in the water column;D) Provide a new, comprehensive and synoptic data set for validation of vertical fluxes of energy and matter calculated by physical and biological models;E) Develop l-D physical models for the computation of statistical moments of microstructure phenomena and integrated biological-physical models of the water column, including fluxes from the surface and the sediment;F) Test and validate the models against measurements of mean and fluctuating properties in the water column;G) Provide modules for vertical exchanges which can be implemented instate-of-the-art 3-D water quality and ecological models. The project is founded on the integration of experimental, theoretical and modelling studies of vertical exchanges in shelf seas, including the joint analysis and interpretation of measurements and model calculations. Innovative measurements of turbulence properties in continental shelf seas (dissipationrate throughout the water column and intensity over a wide frequency range) are the heart of the proposal. These, together with biological measurements concentrating on fluxes near the sea bed, will be made at two contrastin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mass measurements of neutron-rich nuclei by means of the time-of-flight technique at SPEG' (SPEG04) targeting Sixth Framework.

assistant: **Abstract**

The measurement of the masses of very neutron-rich nuclei is of great interest because it reflects many of the aspects of nuclear structure and offers a unique test of those components of the nucleon-nucleon interaction that depend on isospin degree of freedom. In fact, novel theoretical predictions show that close to the neutron drip line magic numbers such as N=8,20,40 could disappear and new ones as N=6,16,34 arise. The present project proposes the detemination of the masses of a large number of neutron-rich nuclei located around the shell closures N=20, N= 28 and N=40 where very interesting effects seem to emerge.The proposed measurement is based on the direct time-of-flight method that has been already successfully applied at the high-resolution spectrometer SPEG at GANIL. As a result the masses around 70 neutron-rich nuclei will be determined for the very first time and the resolution in the mass determination of more than 20 other nuclei will be improved.