RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Insulated Programmable Carbon Nanotube Nanowires with DNA Recognition for Nanoelectronics Applications' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The proposed project will develop a novel programmable ultrathin insulating sheet wrapped carbon nanotube nanowire with DNA recognition ability. The proposed work will for the first time create SWCNT insulated by ultrathin insulating layer. ssDNA recognition element will be attached to the coated/insulated SWCNT. Since DNA is one of the most ""programmable"" molecules, such dual-type of ultrathin layer insulated SWCNT-DNA assembly is unique and will have profound effect on development of nanoelectronic (molectronic) devices, nanobiosensors and on whole area of material science. The understanding of experimental variables as well as electronic/insulation characteristic of assembled programmable SWCNT-DNA will have important effect for proposed project, but it will also have dramatic influence on all field of CNT based nanobiomaterials and nanoelectonic devices. In view of the availability of various carbon nanotubes of different structures and DNA strands of different base sequences, the work proposed will represent an important advance in constructing many multiple carbon nanotube programmable self-assembled structures for multifunctional material, sensing and nanoelectronic device applications.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Slimming and Memory-Booster MIcroaLgae Extract' (SMILE).

assistant: **Innovation**

Building up on a successful Phase 1, the French SME MICROPHYT has demonstrated its ability to industrially over-produce specific marine bioactive compounds from selected microalgae. Through innovative and patented processes, it delivers unequalled concentration of these compounds which have already shown preliminary positive effects in the nutrition & health domains. Leveraging the company initial knowledge and expertise, the SMILE program aim at delivering a ready-for-market and highly effective microalgae-based ingredient for food supplement and nutraceutical applications. This ingredient will target weight management and preservation of cognitive function, two current major societal challenges, through a differentiated and sustainable approach. The successful commercial launch of SMILE Ingredient will depend on its ability to create added-value to the industry customers and to demonstrate full safety and efficacy for the end-user. As outcomes of Phase 2, MICROPHYT will deliver demonstrated and reliable information on the future ingredient and will have secured regulatory compliance in order to market SMILE ingredient in the EU and the USA. SMILE project is of strategic importance for MICROPHYT since it allows the company to extend its expertise from microalgae culture to downstream processes, and thus to market a higher added-value product, addressing consumers’ needs for natural and safe ingredients. As the new MICROPHYT’s “star product”, SMILE is essential to foster company’s competiveness and to strengthen its position on attractive and profitable market segments. At mid-term, this disruptive innovation has the potential to change the dynamics of food supplement market. With at least two new patents filed, SMILE will represent more than 85% of MICROPHYT’s sales an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cork wastes recycling in high prformance isolation composite panels.' (1998-2002) under Fifth Framework.

assistant: **Objectives**

In the European Union is produced the great majority of the worldwide cork production, mainly in Portugal (50%) and Spain (30%). As consequence of the production processes, are generated a big amount of cork residues that can note used. Those wastes are suitable to be used as raw material for another products as: I. Cork wastes from cork manufacture recycling. Isolation panels in buildings of recycled cork and polymer based composites as new product with new qualities for the construction sectors. Light concrete using cork aggregate for special uses. The aim of this proposal consists in the characteristic cork waste identification to determine if it can be used in the purposes aforementioned. These products would be used as construction materials, improving the existents in price and performance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Complex eco-evolutionary dynamics of aquatic ecosystems faced with human-induced and environmental stress' (COMPLEX-FISH) under Horizon 2020.

assistant: **Objectives**

Resilience and recovery ability are key determinants of species persistence and viability in a changing world. Populations exposed to rapid environmental changes and human-induced alterations are often affected by both ecological and evolutionary processes and their interactions, that is, eco-evolutionary dynamics. The integrated perspective offered by eco-evolutionary dynamics is vital for understanding drivers of resilience and recovery of natural populations undergoing rapid changes and exposed to multiple stressors. However, the feedback mechanisms, and the ways in which evolution and phenotypic changes scale up to interacting species, communities, and ecosystems, remains poorly understood. The objective of my proposal is to bridge and close this gap by merging the fields of ecology and evolution into two interfaces of complex biological dynamics. I will do this in the context of conservation and sustainable harvesting of aquatic ecosystems. I will develop a novel mechanistic theory of eco-evolutionary ecosystem dynamics, by coupling the theory of allometric trophic networks with the theory of life-history evolution. I will analyse the eco-evolutionary dynamics of aquatic ecosystems to identify mechanisms responsible for species and ecosystem resilience and recovery ability. This will be done through systematic simulation studies and detailed analyses of three aquatic ecosystems. The project delves into the mechanisms through which anthropogenic and environmental drivers alter the eco-evolutionary dynamics of aquatic ecosystems. Mechanistic understanding of these dynamics, and their consequences to species and ecosystems, has great potential to resolve fundamental yet puzzling patterns observed in natural populations and to identify species and ecosystem properties
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MARie Curie Intelligent UltraSound' to be submitted under Horizon 2020.

assistant: **Abstract**

Cardiovascular diseases (CVD) are the number one cause of death in EU. Echocardiography is the most important imaging tool to assess cardiac function, since it is real time, cost effective and can be performed without discomfort and harmful radiation. A typical cardiac ultrasound examination takes 30-40 min, with image analysis and reporting doubling this time. Thus, cardiologists are now calling for a step change in diagnostic speed and accuracy to allow significant improvements for the care of CVD patients. We propose to develop intelligent algorithms to provide diagnostic support by automatic interpretation of regional cardiac contraction patterns and myocardial image texture. MARCIUS will leverage recent progress in machine learning to train a neural network to recognize unique disease states using a large database of patient data with known pathophysiology and outcome augmented with virtual patient data obtained using a well-validated mathematical model of the heart and circulatory system in combination with a beyond the state-of-the-art ultrasound simulation tool. The resulting diagnostic algorithm will be validated clinically. MARCIUS will take on research activities with high added value, both clinically for patients suffering from cardiac diseases, commercially for the industrial beneficiary and societally with reducing healthcare costs. The long-term and high-risk aspect of these activities makes them unsuited for execution within a normal product development context. Through training and knowledge development in a focused research project built on a unique combination of state-of-the-art technologies, MARCIUS will provide Europe with researchers trained with the cross-disciplinary understanding and skills necessary to develop enabling technologies in an indus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Exploring the diagnostics market for simple and fast point-of-care antibody detection'.

assistant: **Objectives**

Antibody detection assays are used in many fields of biomedicine including the diagnosis of infectious diseases, autoimmune diseases and allergies. Current analytical techniques for antibody detection come with intrinsic limitations such as the requirement for multiple time-consuming incubation steps, multiple reagents, and/or sophisticated equipment. Supported by an ERC consolidator grant we have developed a highly modular sensor concept for  antibody-responsive reporter enzymes (AbSens) that addresses many of these challenges. Key advantages include the ability to monitor antibodies directly in solution, easy read-out based on a simple color reaction, adaptability to target any antibody of interest, and high affinity and specificity. We believe that this generic sensor platform could find applications in low-cost point-of-care diagnostics, clinical research, and the development of therapeutic antibodies.The goal of AbSens is to identify those opportunities in the huge market of antibody-based diagnostics where our sensor platform provides unique advantages over existing technologies, both in terms of analytical performance and economics.To enable the next step towards commercialization, the analytical performance of our technology will be compared to current gold standards using relevant clinical samples in collaboration with commercial parties and clinicians. Other commercially important parameters are the long-term stability of the assay components and the development of a yeast-based production system to lower the cost of enzyme production. Based on an in-depth market analysis and the feedback we receive from external stakeholders on the performance of our technology, a realistic strategy will be developed for the further commercialization. In anticipation of explo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MOLECULAR CYTOGENETICS 2001-2002' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Molecular cytogenetics is a more and more widespread and successful field of research and discovery in the field of genetics. Molecular Cytogenetics techniques are crucial in Tumor Cytogenetics (with special reference to hematological malignancies) and in prenatal diagnosis. While there are many cellular-level genetics courses throughout Europe, the average training activity of this kind is usually pretty focused on very particular and technical topics. On the other hand, there is a strong need for young researchers to get learned about the numerous and different technical and scientific approaches to this field, which are developed throughout the most advanced laboratories in Europe. A European effort to develop training programmes in the field of genetics requires a strong support for molecular cytogenetics, both for its more and more widespread and successful use, and for exchanging and/or integrating the different viewpoints about this topic.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2001-00194-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Brain computer interface to study and manipulate mamories of aversive experience during sleep' to be submitted under Horizon 2020.

assistant: **Abstract**

The aim of this project is to study the influence of sleep in the establishment of aversive memory and to propose a proof of concept for the use of brain-computer interfaces during sleep to treat pathologies associated with fear or anxiety such as post-traumatic stress disorders. It is now  accepted that sleep plays a crucial role in memory consolidation processes that allow the conversion of newly encoded memory traces into more stable information. Numerous studies have shown that some of the positive effect of sleep on consolidation relies on the reactivations of previous experiences. We recently showed that spontaneous sleep reactivations can be used to create an artificial memory during sleep. We made electrical stimulations of a brain reward center contingent on the spontaneous reactivations of a hippocampal place cell during sleep. After this procedure, mice developed a place preference for the location of the place field of the trigger cell, showing that a place/reward association had been created. Our experiment, as most of the studies on place cells or reactivations, was done with appetitive learning and we now intend to tackle this issue in the context of aversive learning. In this project, we will use our closed-loop device to address long lasting controversies such as the existence of reactivations in deep SWS or REM sleep. We will also investigate how avoided places are represented in the hippocampus and whether they are more reactivated during subsequent sleep. Additionally, we will show whether aversive-related wake preplays can be actively modulated, suggesting that “intrusive memories” or rumination can be addressed in animal models. Finally, we will test whether an aversive association performed during wake can be modified by our closed-loop-driven app
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'TRACING IDENTITY IN THE EASTERN MEDITERRANEAN; A Digital Survey of Late Medieval Monuments in the Eastern Mediterranean Islands'.

assistant: **Concept**

This project proposes the interdisciplinary examination of the monumental heritage of the Medieval Mediterranean. Specifically, the program’s objective is the creation of a comprehensive digital repository of the late medieval monuments of the islands of the Eastern Mediterranean using state-of-the-art technological tools. Research will cover the eastern part of the Mediterranean basin beginning with Cyprus, Rhodes and Chios to be progressively extended to Crete and other Aegean islands. The program offers a novel methodology that adjusts to the complex socio-political realities of the Medieval Mediterranean. Research focuses on the understudied period that followed the collapse of the Latin kingdom of Jerusalem in 1187 until the capture of Crete by the Ottomans in 1669. In this volatile environment, Cyprus, Chios, Rhodes and Crete became Europe’s gateways to the East; as such, they will be the central examples of this study. These islands will not be isolated studies but the pivotal mirrors to explore the region. The proposed methodology offers three levels of analysis starting from the broader geographical bodies and their location in the region, then moving to the specific locales, to finally study individual monuments. The application of informatics, GIS technologies, the use of digital libraries, and the utilization of scanning and CAD technologies will offer an invaluable record of extant architectural and archaeological remains. The in-depth documentation of surviving monuments in the above islands will be followed by the comparative examination of physical evidence against textural sources and the historical background of the period. Hosted by the Cyprus Institute, the proposed program traces aspects of the formation and appropriation of social and religious ide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The role of ubiquitin and ubiquitin-like modifiers in replication stress'.

assistant: **Objectives**

Accurate DNA replication is an essential prerequisite of genome stability, and nature has evolved numerous mechanisms to ensure precise and complete genome duplication. Subversion of these protective mechanism results in genome instability, the hallmark of cancer and many human developmental syndromes. Paradoxically, recent evidence suggests that pharmacological interference with these mechanisms represents a promising therapeutic strategy, because cancer cells show a pronounced dependency on these pathways for their survival. One of the most important requirements for faithful DNA replication is the maintenance of replication fork stability under conditions of stress. A number of proteins involved in this process have been identified to date; however, our understanding about their post-translational regulation is rather vague. In particular, although their indispensable role in DNA damage signaling is firmly established, the role of ubiquitin and ubiquitin-like modifiers responding to DNA replication stress has so far not been addressed. We propose to combine high-content microscopy with reverse genetics to identify ubitiqutin-related factors and pathways in the response to DNA replication stress. To this end, we will set up a dual labeling protocol for the quantitative detection of DNA synthesis – an approach never exploited for high content studies. To realize the full potential of this approach, comprehensive expertise in high-content microscopy and RNAi based screens are essential – both of which are among the core competencies of the host institution. We will characterize novel regulators by a combination of basic and highly specialized, biochemical, molecular and cellular biology and physicochemical techniques. We are confident that the results of this study will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Plasma-based point-source CCU technology to recycle CO2 into added value chemicals to decarbonize hard-to-abate industries' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Spin-off from University of Antwerp (PLASMANT research group), D-CRBN is a climate tech company which has developed a cutting-edge technology that enables the conversion of CO2. We recycle captured CO2 and split it into its original building blocks thanks to our proprietary plasma-based technology whose efficiency is 5x higher (or more) than current systems. Our Carbon Capture and Utilization (CCU) process enables not only to decarbonize hard-to-abate industries by eliminating their point source emissions but also to create new value-added products such as e-fuels, polymers, and chemicals. In this way, CO2 recycling is the cornerstone of a circular carbon economy that supports a net-zero future.We offer one of the most profitable, sustainable, and flexible CO2 recycling solutions to the petrochemical, steel industry, and maritime transport. In other words, we turn a harmful gas causing climate change into a business opportunity.


**Keywords:** Carbon capture, utilization, and storage (CCUS); CO2 recycling; plasma-based CO2 conversion; electrified CO production; plasma reactor; hard-to-abate industries; circular economy