RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Reversible and irreversible cardiac electroporation: Establishing the fundamentals to advance cardiac treatments'.

assistant: **Innovation**

Cardiovascular diseases are the No. 1 healthcare challenge in the world, among which ischemic heart disease and atrial fibrillation are the most prevalent. Better treatment strategies are greatly needed to reduce the medical, economic, and social burden of these conditions.Electroporation (application of intense pulsed electric field) is showing tremendous potential for treatment of atrial fibrillation, enabling a safer and shorter treatment procedure compared with existing thermal ablation approaches. Moreover, recent pioneering studies provide evidence that electroporation can also be used as a nonviral vector for intracellular delivery of therapeutic nucleic acids that promote cardiac regeneration, potentially offering a way to cure the so-far incurable ischemic heart disease.For treatment of atrial fibrillation, electroporation must be irreversible, resulting in the death of cardiac muscle cells, to locally destroy (ablate) the arrhythmogenic cardiac tissue. Conversely, for treatment of ischemic heart disease electroporation must be reversible, meaning that the pulsed electric field transiently enhances cellular uptake of nucleic acids while the cells are able to survive and express the delivered transgene(s). Due to a lack of fundamental understanding of cardiac electroporation, there are currently no reliable methods able to ensure electroporation (ir)reversibility and the desired treatment outcome.This project is designed to decipher the biophysical mechanisms of cardiac electroporation at the molecular, cellular and tissue level as to develop methodologies that will enable optimal implementation of both irreversible and reversible electroporation. By combining bottom-up experiments in primary cardiac cells and tissue slices with computational modeling and advanc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Innovative Methodologies for New Food Product Development: combining Sensory Science and Experimental Economics' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

European food industries have to continue developing new food products in order to improve their competitiveness on the increasingly competitive food market. It is a generally accepted fact that far too many new food introductions on the food market fail every year which negatively affect business performances in the food industry. This high failure rate is widely recognised to be due to the lack of incorporation of the consumer-voice in the process of new food product development (NPD). Afterall, consumers take into account a large number of product attributes, both intrinsic and extrinsic, when making food choices. The food industry requires a manageable protocol for NPD which includes more realistic marketing information. The project aims to illustrate a formalised and innovative methodology which combines both intrinsic and extrinsic food attributes, therefore acquiring a better understanding of consumer acceptance of novel food in real market buying situations in order to contribute to the improvement of the process of NPD. With this in mind, a multidisciplinary and international research approach is necessary which involves different scientific disciplines, such as food and economic sciences, as well as strong collaboration among research institutes and the food industry. Points of investigation will be high quality novel foods which are expected to be introduced into the food market in the near future. Novel foods to be investigated will be identified through qualitative research carried out with experts and food industries. Then, sensory analysis and qualitative consumer research will be performed. Finally, quantitative consumer survey will be designed and carried out by applying a new scientific methodology based on an innovative experimental economic approach.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The EDUCAGE: A Behavioral Platform for Naturalistic Learning' (EDUCAGE).

assistant: **Concept**

Understanding behavior is still one of the holy grails in the natural and social sciences. Behavior is often utterly complex because it is a result of an extremely rich set of past experiences, the present state of the animal and the animal’s predictions about the future; all of which affect learning, decision making and consequently behavior. Given the complexity of behavior, most researchers work in the realm of highly simplified learning tasks but these only test very basic attributes of learning and are constraining discovery of more sophisticated behavior. To date, there are only few available platforms for rigorous study of complex behavioral paradigms in experimental animals; not in basic science nor in biomedical research. Our goal is to bring to completion (and potential commercialization) a novel platform for analyzing complex animal behavior named “The Educage” to allow fully automatic, hands free assessment of higher cognitive functions in freely behaving animals. Potential customers are research labs, and the biomedical industry. The Educage will allow researchers to study behavior at unprecedented resolution, 24/7, for any duration of time. The learning paradigms can be tailored to the specific task of interest. The Educage has many advantages that outperform existing technologies by allowing rigorous statistical assessment of complex behaviors in laboratory animals. The Educage allows researchers the flexibility to monitor, analyze and manipulate the experiment during the behavior. Our system can be reliably used to analyze perceptual learning in mice and is well suited for being a new and rigorous behavioral platform. It has great potential to become a central tool to fuel discovery in animal research both in biology and biomedical research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'GÉANT Horizon Europe GN5-IC1'.

assistant: **Innovation**

Under the new 72-month GN5 Framework Partnership Agreement in Horizon Europe (GN5-FPA), this proposal responds to Horizon Europe Call HORIZON-INFRA-2021-NET-01-SGA-2 (Work Programme ’21-22 Other Actions: 2. SGA for investments on International connectivity and collaboration), received 1 February 2022.  GN5-IC1 sets out a new plan and implementation for the first phase of a new intercontinental connectivity investment programme, meeting the huge growth in network capacity demands and leading the network through a paradigm shift in the digital science and computational infrastructures in the next 10 to 15 years. It builds on the successful and relevant experience in planning and procuring and introducing into operation direct intercontinental links, such as BELLA S1, as well as a number of other existing bilateral and reciprocal arrangements for operational links negotiated with other intercontinental partners. This project will help ensure sufficient capacity is put in place through procurements and implementations of links during the project term or through setting a roadmap for future investments beyond this timeframe.The GÉANT Consortium has a long established and successful track record in securing long-term intercontinental network connectivity, interconnecting with an increasing number of gateways in the network, in co-ordination with global peers. Applying proven skills and expertise, GÉANT is well placed to maximise the value of the links to be procured, with innovative contracts and to secure reciprocal global peering contributions to increase the impact of the resources available in GN5-IC1.


**Keywords:** connectivity, networks, research networking, multi-domain networking, communication networks, secure, trust, innovation, media, digital sovereignty, compute
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Structural studies on calmodulin - novel modes of binding of calmodulin to target enzyme sequences from phosphofructokinase' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content Calmodulin is a calcium binding protein ( 148 residues) which can respond to changes in calcium concentration and cause activation of a number of important enzymes. High resolution structures have been reported for calmodulin complexed with target peptides from muscle myosin light chain kinases and calmodulin kinase II. These show the 'canonical' structure of a largely helical peptide embedded between the two domains of calmodulin. In the case of the phosphofructokinase, the regulation is unusual in that Ca2+ -calmodulin causes inhibition of the enzyme. Peptides from its target sequence for calmodulin binding have been synthesised and Circular Dichroism studies of their complexes with calmodulin suggest that these peptides have a different mode of interaction: the characterisation of this conformation could provide the first high resolution structural evidence of a target conformation other than the canonical form. The object of this project is to determine the conformation of the bound peptides and the structure of their binding sites using multidimensional Nuclear Magnetic Resonance methods (including isotopic editing techniques) on calmodulin-peptide complexes. Labelled (15N/ 13C) calmodulin has already been prepared and a detailed set of multidimensional NMR experiments will be carried out to determine the constraints required to calculate the structures of the complexes. Training content (objective, benefit and expected Impact) Learning to use apply modern multidimensional Nuclear Magnetic Resonance techniques for examining protein-ligand complexes and for determining their structures. Methods for examining multiligand binding will be learnt. Circular Dichroism and other spectroscopic techniques will also be used. Links with industry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Unified Novel Deep ExploRation for Critical Ore discoVERy' (UNDERCOVER) under Horizon Europe.

assistant: **Objectives**

Recent EU initiatives for a circular 'Net Zero' economy highlight the need for increased raw materials, especially critical mineral resources (CRMs). Traditional exploration methods are limited in scale and depth, often missing large CRM deposits under thick cover (500-1000 m). UNDERCOVER aims to transform deep CRM exploration, introducing a paradigm shift by extending the mineral systems concept, currently underutilised in quantitative exploration, to exploration relevant spatial scales. UNDERCOVER integrates key technologies developed by EU academia and companies:- Low-cost lithosphere-scale surveys (e.g., MT and passive seismic) in full 3D target prospective regions.- Regional scale mapping using innovative airborne techniques for identifying exploration targets beyond 1 km depth.- Improved cost efficiency for high-resolution, deeply penetrating seismic and EM methods (e.g., compressive sensing or drones) for deposit study and environmental exploitation planning.- Application of AI and joint inversion methods to integrate multi-scale, multi-method, geological, geochemical, and geochronological data, resulting in a 4D multi-scale mineral systems model.- Incorporation of ESG studies to increase social acceptance and the adoption of our technologies.- Introduction of UNFC guidelines, integral in our novel exploration strategy as part of the Value of Information.UNDERCOVER’s strategy envisions public-private partnerships collecting precompetitive regional and lithospheric data across Europe. Companies can leverage this data to de-risk exploration programs and enhance funding prospects. The anticipated impacts are substantial – a systematic and reliable approach to deep exploration could double the EU CRM potential, achieved at a lower cost than conventional methods. Case
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Materials’ Innovations for a Safe and Sustainable nuclear in Europe', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The European Energy Research Alliance, set-up under the European Strategic Energy Technology Plan, has launched an initiative for a Joint Programme on Nuclear Materials (JPNM). The JPNM aims at establishing key priorities in the area of advanced nuclear materials, identifying funding opportunities and harmonizing this scientific & technical domain at the European level by maximizing complementarities and synergies with the major actors of the field. The JPNM partners propose, through MatISSE, a combination of Collaborative Projects and Coordination and Support Actions to face the challenge of implementing a pan-European integrated research programme with common research activities establishing, at the same time, appropriate strategy and governance structure. Focusing on cross-cutting activities related to materials used in fuel and structural elements of safe and sustainable advanced nuclear systems, the project aims at covering the key priorities identified in the JPNM: pre-normative research in support of ESNII systems, Oxide Dispersed Strengthened steels, refractory composites for the high temperature applications, development of predictive capacities. MatISSE will foster the link between the respective national research programmes through networking and integrating activities on material innovations for advanced nuclear systems, sharing partners best practices and setting-up efficient communication tools. It is expected that, through MatISSE, a real boost toward Joint Programming among the Member States, the European Commission and the main European research actors, will be achieved.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Multifunctional Spin Crossover Materials' (SPINSWITCH).

assistant: **Innovation**

This project deals with an exchange programme of seven research teams with the aim to establish and consolidate a network for the design of innovative multifunctional materials based upon iron(II) spin crossover complexes: their synthesis, magnetic and spectroscopic studies, investigations on their crystalline, liquid crystalline and morphological structures, pressure effects on spin crossover properties and, particularly, their implementation into pressure sensors. The synthetic part of this project aims to access novel types of crystalline and liquid crystalline spin crossover complexes, hybrid luminescent materials, photo-switchable liquid crystalline compounds, composites and nano-objects of original morphologies and transition characteristics. These switchable materials will become a matter of different experiments under pressure: magnetic and Mӧssbauer measurements under hydrostatic pressure and optical experiments in a gas pressure cell. This will allow to reach an important impact on the synthesis of new bistable materials, on their behaviour under pressure, and to make them an active part of different pressure sensors. The academic participants involved in this work have collaborated on joint projects and have co-authored several scientific papers. The two industrial institutions have a recognized expertise in organic and material synthesis, commercialization, as well possessing experience on elaboration of spin transition materials. The establishment of this joint exchange programme will promote and strengthen the complementarity of the participants and will stimulate cross-fertilization, thus forming an excellent centre of synergy in research, innovation and technology in the area of functional materials. This network offers a complete training in the synthes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Female Slavery in Mediterranean Catholic Europe, 1500-1800' (FemSMed), addressing dissemination and exploitation.

assistant: **Impact**

More than one million, and perhaps as many as two million individuals were enslaved in the Catholic regions of the early modern Mediterranean. Despite evidence of the prevalence of female slavery and of the fact that women constituted the bulk of the enslaved population in some areas, scholarship on bondage in Mediterranean Europe from 1500 to 1800 retains a strong androcentric bias. Transcending national historiographic traditions, FemSMed will break new ground by providing, for the first time, a comprehensive investigation of women’s enslavement and its wide-ranging implications during the pivotal period in European history that encompassed the Renaissance, the Reformations, the onset of European colonialism, the Scientific Revolution, and the Enlightenment. Whereas extant scholarship emphasizes religious, political, and economic aspects, FemSMed’s goal is to uncover the sexual, familial, and broader social contexts of these aspects. By elucidating the long-term consequences of women’s enslavement, it further aims to reveal the gendered mechanisms of racialization and ethnicization, and raise awareness of Europe’s multiethnic and multireligious heritage. This will be done by exploring 1) typologies of slave women’s abuse and their implications for perceptions of illicit sexuality and gender-based violence; 2) how the birth of children under slavery bore on the creation of categories of difference; 3) the impact of domestic female slavery on slaveholders’ family life and on conceptualizations of consanguineal and affinal kinship; 4) how the enslavement of minority women shaped collective identities and intercommunal relations. Informed by theoretical advances in the sociological and anthropological study of slavery, FemSMed employs methodologies from social and religio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Second International Congress on Mismatch Negativity and its Clinical Applications' (1998-2002).

assistant: **Concept**

The Second International Congress on Mismatch Negativity and its Clinical Applications aims at creating a unique exchange forum to update the current state-of-the-art on the mismatch negativity (MMN) and related electric and magnetic brain responses. MMN, being elicited to any acoustic change in a sequence of repetitive stimulation, provides a unique physiological measure of sound discrimination accuracy, auditory sensory memory and involuntary attention in health and neurological and psychiatric disease. MMN appears as a promising tool for the prognosis of recovery from coma, to detect perceptual language dysfunction in children with developmental disorders (such as dysphasia or dyslexia), to assess the success of cochlear implants, and to monitor the development of cognitive brain functions in pre-term new-borns and in neuropediatric disorders.During the Congress, an enriched atmosphere will be created for the most experienced researchers, working on the latest advances on the MMN and its clinical applications, to impart their knowledge and experience to the new generation of young researchers and clinicians. The Congress will review the most promising clinical applications of MMN and related basic research through four plenary lectures and six planned symposia. A tutorial on MMN, arranged in a goal-oriented, problem-solving approach will provide the participants with a complete overview on the practical issues concerning MMN recording. A round table on MMN clinical prospects and the poster session will offer the participants with a more informal atmosphere facilitating discussion and exchange of ideas. The Congress will be held at the University of Barcelona (Catalonia, Spain), in June 15-18-2000. To ensure that the new generation of researchers benefits from the adv