RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'MULTIMEDIA GEOCENTRIC NETWORKED ENVIRONMENT'.

assistant: **Innovation**

The main objective of the GeoNet 4D project is to evaluate and develop multimedia-based access to online cartographic information, using easy-to-use interfaces based on geographic data for information presentation, navigation, search and retrieval.The project is driven by the conviction that interfaces based on interactive 'smart maps' will become a standard in distributed communications and networked computing. Such intuitive multimedia tools will support the creation of a wide range of new value-added services, especially where complex information resources are used for group collaboration. GeoNet 4D addresses the technical and design issues required to work across platforms using a scaleable modular architecture, and aims to develop an open systems environment that will permit diverse users to work together easily over networks via animated smart maps which include 4D multimedia information. Such an online cartographic system integrates several key components: - 3D capacity to enable visualisation of mapping information on buildings, mountains, the sea bed, pipelines, statistics, etc. - 4D time stamping to allow the display of time-related data from hydrodynamics, movement of objects on the sea, simulations, etc. - networking to support fast collection, integration and online distribution of information between different users. Use of ATM, ISDN, TCP/IP and IPng functions and protocols. - Object Oriented Database Management System (OODMS) client server engineering to permit correlation of users, multimedia and GIS data, temporal and spatial information, threaded and meta-linked data, security and transaction processing, etc. - World Wide Web client server protocols and browser design/development, including full use of Java, VRML, OGIS and MHEG for easy online access t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Combating desertification in mediterranean europe : linking science with stakeholders' (DESERTLINKS) targeting Fifth Framework.

assistant: **Abstract**

DESERTLINKS will support stakeholders at the local, sub-national and national level in combating desertification. It will bring the results of past research on the physical and socio-economic aspects of desertification to bear on practical ways to combat it at various geographical scales from the local to the European.DESERTLINKS will provide indicators to monitor desertification as well as syntheses of the understanding of the physical and socio-economic processes that cause it. It will establish the ways in which major current Mediterranean-wideband uses are affecting desertification. It will show how to mitigate its effects by taking different land management decisions at both the public policy and individual level and by adopting practical land management techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Receptor-Doped Ionogels: New Materials for Inherently Biocompatible Molecular Sensors' under Seventh Framework.

assistant: **Concept**

The issues faced today with biochemical sensors are device reliability and power consumption, liquid handling over extended periods of time, as the micro-dimensioned fluidic channels are prone to blockage, and micro pumps/valves being unreliable. The aim of this proposal is to develop a biocompatible molecular sensor that would address the key issues holding biocompatible sensors and would be at the forefront of molecular sensing. Advantages of such sensors would be selectivity for target ions in the body such as sodium, potassium and calcium. Sensors of this nature would be important in areas of every day life for example, monitoring cancer, / cancer pass surgery, obesity and people recovering from heart surgery. Such molecular sensors would contain hybrid materials consisting of monomeric components polymerized within biocompatible ionic liquids yielding various platforms for modification. Doping of the ionogel hybrid material with a selective ionophore will enable ion selectivity and hypothetically develop any chemical or biological sensor by introducing its corresponding selective ionophore. This type of material would render most optical sensing technologies on the market obsolete.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

The EN-ACTI2NG program (European Network on Anti-Cancer Immuno-Therapy Improvement by modification of CAR and TCR Interactions and Nanoscale Geometry) emanates from the recent clinical evidence that T cells expressing engineered tumor-specific immune receptors can eradicate certain tumors that do not respond to conventional treatment. To obtain T cells with reactivity to a wider array of tumors and to improve efficiency and on- and off-target toxicity are current challenges Therefore the EN-ACTI2NG program aims 1) to train PhD students with expertise in development of new and improved T cell-mediated cancer immuno-therapies; 2) to endow the PhD students with the ability to establish efficient communication between the academic and industrial research environments and between scientists and the general public; 3) to improve T cell mediated anti-cancer immuno-therapy by the identification and development of new cancer-specific immune receptors and enhancing their function by identifying and modifying their molecular mechanism of action. To reach these objectives we have designed individual research projects ranging from biophysical analysis of immune receptors, via molecular modification of their structure and testing their tumor killing capacity in cell-based and pre-clinical assays to product development. Secondments will assure that each PhD student will be exposed to these complementary approaches and that there will be synergic feedback between the projects, producing innovative results that could otherwise not be achieved. Extensive training in research-specific skills, career development and a continuous training in communication skills will allow the PhD students to become facilitators of the process of transformation of scientific innovation into products with so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Peptidomimetic therapy to promote central Nervous System repair' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Vision enables 70% of our sensorial interactions with the outside world, making blindness a devastating condition with profound impact on quality of life. Glaucoma, the second leading cause of blindness globally after cataracts, affects over 80 million people worldwide, including more than 1 million in France alone. The disease impacts approximately 2% of the population over 40 years old and 10% of those over 70. With an aging global population, these numbers are projected to rise significantly in the coming years.Glaucoma is fundamentally a neurological disorder characterized by optic nerve degeneration and death of Retinal Ganglion Cells (RGC), the crucial neurons that transmit visual information from the eye to the brain. The primary treatment approach focuses on lowering intraocular pressure (IOP) through medications like prostaglandins and beta-adrenergic receptor antagonists, or through surgical intervention. However, these treatments are purely preventative - they can only protect remaining healthy neurons and slow disease progression. They cannot reverse existing damage to the optic nerve or prevent RGC death in advanced cases. Moreover, not all forms of glaucoma are associated with elevated IOP, leaving some patients without effective treatment options. POPEYE introduces a groundbreaking approach to treating glaucoma that represents a significant departure from existing therapeutic strategies. Our innovation lies in developing a first-in-class therapeutic that directly promotes functional recovery through axon regeneration and proper neural circuit reconstruction.The cornerstone of our innovation is the novel use of synthetic peptides to promote both axon regeneration and precise pathfinding. This dual action mechanism distinguishes our approach from all existi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A novel modeling framework for predicting animal communities under global change' (SESAM-ZOOL).

assistant: **Innovation**

A major challenge of the coming years will be to maintain biodiversity under changing environmental conditions. Anticipation is an important dimension to tackle this challenge, where models play a major role. So far however, our capacity to predict communities from single species has remained limited. We now need to improve existing models and develop new ones to better account for assembly processes. This is the aim of the recently proposed SESAM framework (Spatially-Explicit Species Assemblage Modeling). Arising from this theoretical formulation, I aim to develop, implement, and test an innovative framework to model species assemblage combining many pre-existing approaches to biodiversity prediction to produce improved spatially explicit projections and overcome single methods limitations. As efforts are currently made on plants, this project will be the first to attempt this comprehensively on animal assemblages, here European reptiles, in 3 nested study areas. To ensure its feasibility, it will be developed in a step-by-step way: i) gathering species and environmental data; ii) performing modeling analyses (species distribution models) to obtain the potential composition of assemblages filtered only for abiotic constrains; iii) defining macroecological constraints on community properties through macroecological modeling; iv) identifying species interactions and deriving ecological assembly rules (EARs) for the considered assemblages, to be used as biotic filter; v) using data and results previously obtained to unify all components; for this, I aim to develop a highly original step to integrate the identified EARs in the novel predictive process. I will test the robustness and scale-dependence of all component and of the whole framework; and finally vi) applying the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a new dispersion technology for the production of macromolecular flocculants' (1998-2002).

assistant: **Concept**

Based on their considerable experience within the field of mixing technologies especially in the high-viscosity product range (Prime proposer HEBOLD) and in the production of PA and PSA (Second proposer ACIDEKA) it is the proposers intention to develop a new process enabling the production of highly reactive precipitation agents and precipitation support agents. Initially the products should fulfill the following requirements: - High performance/reactivity due to a high content on polymers with a high molecular weight. - Reduction of the dosage needed compared to conventional chemicals by 20 % - Negligible residual monomers (98/83/EC) - Thermodynamic stability - Ready to use without dissolution or stirring and easily invertible when poured in water- Liquid and low viscosity products which simplifies their handling The proposed work programme for the intended research project will be finalized during the exploratory phase.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Motivic Cohomology of Schemes' under Horizon 2020.

assistant: **Concept**

The project belongs to the field of arithmetic algebraic geometry and is centred around algebraic K-theory, motivic cohomology, and topological cyclic homology. The overall goal is to develop a general theory of motivic cohomology for arbitrary schemes, extending the existing theory of Bloch, Levine, Suslin, Voevodsky, and others in the special case of smooth algebraic varieties. This will describe non-connective algebraic K-theory via an Atiyah--Hirzebruch spectral sequence. The project relies on very recent breakthroughs in algebraic K-theory and topological cyclic homology.In the case of singular algebraic varieties, our goal will be to develop a theory of motivic cohomology which both satisfies singular analogous of the Beilinson--Lichtenbaum conjectures and is also compatible with the trace maps to negative cyclic and topological cyclic homology. Its properties will refine those of K-theory in the presence of singularities; for example, we will study a motivic refinement of Weibel's vanishing conjecture and a theory of ``infinitesimal motivic cohomology'' satisfying cdh descent.In the case of regular arithmetic schemes we will propose a new approach to the theory of p-adic motivic cohomology, based on topological cyclic homology and syntomic cohomology, which works in much greater generality than previous approaches. Perfectoid techniques will play an important role and we will establish the p-adic Beilinson--Lichtenbaum and Bloch--Kato conjectures.


**Keywords:** Motivic cohomology, K-theory, topological cyclic homology, syntomic cohomology, p-adic schemes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Archaeal keystone species in host microbiomes: Understanding and controlling Methanobrevibacter for Environmental and Health Benefits', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Archaea, the most ancient domain of life, play a crucial yet largely underappreciated role in human microbiomes and Earth's nutrient cycles. Among them, Methanobrevibacter species are particularly important for methane production in ruminants, accounting for up to 6% of anthropogenic greenhouse gas emissions and are prevalent in animal and plant microbiomes. In recent years, I have become intrigued by the impact of Methanobrevibacter on human physiology. Our research has shown that two distinct Methanobrevibacter species influence the availability of essential vitamins and metabolites by shaping the entire gut microbiome. Despite their recognized importance for health, our mechanistic understanding of archaeal dynamics and communication within the human microbial ecosystem remains limited due to technical challenges and a historical research bias. Methanobrevibacter never acts alone but relies on complex syntrophic, mutual interactions with bacteria. In these inter-domain networks, Methanobrevibacter functions as central hub. This creates an exciting possibility to strategically manipulate human microbiomes through a unique focus on the archaeal component. Given their distinct biological features, a major challenge is developing a robust methodological toolkit and engineering synthetic archaeal-bacterial consortia with therapeutic potentials. Through an integrative approach combining computational, experimental, and in vivo studies, I aim to elucidate the underlying mechanisms governing Methanobrevibacter networks, with the overall goal of elevating Methanobrevibacter to a central position in microbiome research. The gained knowledge will deepen scientific understanding of archaea and yield valuable applications in host-associated microbiomes. With extensive, globally u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Cholesterol and Sugar Uptake Mechanisms'.

assistant: **Concept**

Cardiovascular disease, diabetes and cancer have a dramatic impact on modern society, and in great part are related to uptake of cholesterol and sugar. We still know surprisingly little about the molecular details of the processes that goes on in this essential part of human basic metabolism. This application addresses cholesterol and sugar transport and aim to elucidate the molecular mechanism of cholesterol and sugar uptake in humans. It moves the frontiers of the field by shifting the focus to in vitro work allowing hitherto untried structural and biochemical experiments to be performed.Cholesterol uptake from the intestine is mediated by the membrane protein NPC1L1. Despite extensive research, the molecular mechanism of NPC1L1-dependent cholesterol uptake still remains largely unknown. Facilitated sugar transport in humans is made possible by sugar transporters called GLUTs and SWEETs, and every cell possesses these sugar transport systems. For all these uptake systems structural information is sorely lacking to address important mechanistic questions to help elucidate their molecular mechanism.I will address this using a complementary set of methods founded in macromolecular crystallography and electron microscopy to determine the 3-dimensional structures of key players in these uptake systems. My unpublished preliminary results have established the feasibility of this approach. This will be followed up by biochemical characterization of the molecular mechanism in vitro and in silico.This high risk/high reward membrane protein proposal could lead to a breakthrough in how we approach human biochemical pathways that are linked to trans-membrane transport. An improved understanding of cholesterol and sugar homeostasis has tremendous potential for improving general pub
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'New treatments for surgical implants (NEWTRESI)' (NEWTRESI) targeting Sixth Framework.

assistant: **Abstract**

The objectives of thIs project are to set-up two innovative vacuum thin film treatments to be deposited on the surface of surgical implants. We will study two categories of implants: The first category is represented by electronic prosthesis for Intracoclear implants; in this case the treatments must replace the ceramic case now used, too thick, and must have a very high level of barrier against water (body's fluids) and to be dielectric (to guarantee the wireless communication with external parts) and to be biocompatible. The second category is represented by Dental and Orthopaedic Titanium prosthesis; the purposes of this coating are: to protect the prosthesis itself by the erosion of body's fluids, to guarantee a faster Osseo integration (not less than 50% reduction of ossification time), to be biocompatible and to avoid rejection by softening of the interface between bone and implant (more than 20 years of lifetime). To obtain this performances we planned to use two innovative deposition technologies: Ion Plating Plasma Assisted (IPPA) (mainly in the configuration Reactive Low Voltage Ion Plating Plasma Assisted (RLVIPPA); High Density Plasma Enhanced Chemical Vapour Deposition Plasma Assisted (HDPECVD).Using this deposition process we aspect to obtain very dense, compact, adherent and very hard layers. To realize the dielectric barrier treatment for electronic prosthesis we planned to use a multilayer of alternate inorganic and semi-organic layers, deposited by IPPA and/or HDPECVD (such as SiC, AI203 and SiOxCy). We planned to use for dental and orthopaedic implants coatings of TiCxOy TitaniumOxicarbide that, deposited by laser ablation showed the desired properties. The use of the proposed deposition techniques is necessary because Laser Ablation is not suitable f