RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'SMEs, Research & Innovation: Turning knowledge into profit'.

assistant: **Concept**

SMEs are more than ever a fresh topic raising many questions and expectations for Europe’s future. In this regard, the main concern remains the reinforcement of innovation in SMEs. This issue is taken into account through specific programmes and measures intending to transform the innovation challenge into new business opportunities: the Lisbon Strategy, the support programmes 2007-2013 and the Member States’ strategic plans. The Conference on SMEs, Research and Innovation will be based on these observations and will be held under Belgian Presidency, at the ideal period of re-designing of the FP8 and other major EU support programmes (Structural Funds, CIP,...). The overall purpose of the Conference will be: (1) To take stock of the current situation (the business reality in which SMEs operate, existing SME support measures and incentives for technological innovation, lack of support in areas such as service innovation etc.). The focus of the discussion would be on the creation of synergies between existing support measures at regional, national and European level. This forum will directly raise the awareness of participants towards current measures/instruments and economic opportunities open to them. (2) To prepare a comprehensive vision for future SME Research and Innovation policies. Research, innovation, and SMEs should be tightly linked elements shaping Europe’s future. The idea here is to look beyond the 2013 horizon when FP7 and CIP will be finished. Questions to address could include: how to develop research and innovation policies starting from the needs of SMEs?; what sort of research and innovation programmes best address the needs of SMEs?; what role for the MS / EU?; how to create the conditions and environment that will make SMEs more innovative? The resul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European Underground H2 STorAge Reference System' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The overall aim of the project is to demonstrate underground hydrogen storage in depleted porous natural gas reservoirs at TRL-8. RAG Austria AG is in the unique position to start with an already existing pilot facility, developed within the framework of the USS-2030 project (www.uss-2030.at) to TRL 6. EUH2STARS will bring the pilot to TRL8 using results of several relevant projects (HyUSPRe, HyStoRIEs, Underground Sun Storage, Underground Sun Conversion and others).  To achieve the overall aim and maximize the exploitation of the project results for replication in other regions of Europe the following specific objectives and outcomes are planned: - Provide recommendations to best manage all environmental, legal and (future) regulatory, societal and market-related aspects to ensure a successful implementation of an underground hydrogen storage facility in Europe (WP 1) - Provide recommendations on the topic of Health, Safety, Environment and Quality (HSEQ) including a monitoring plan to ensure an ALARP (as low as reasonably practicable) risk level when operating the demonstration site and future commercial storage sites (WP 2) - Run 4 cycles of seasonal operation with different characteristics and usage profiles to demonstrate the ability to integrate with different energy infrastructure systems with highest purification levels of Hydrogen (WP 3) - Show transformation pathways to replicate demonstrator findings in full-scale commercial settings at existing underground gas storage facilities and new to be developed storage sites in depleted natural gas reservoirs in Europe  located in Austria (RAG), The Netherlands (Shell), Hungary (HGS), and Spain (TES)  (WP 4) - Show how to integrate hydrogen storage facilities into the local, national and European energy infrastructur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Synthesis of cyclopeptides from marine origins'.

assistant: **Objectives**

Research objectives and content The project consists of the synthesis of patellin 2 and trunkamide A, two cyclopeptides of marine origin, on a gram scale for the completion of medical trials. These products have not, as yet, been synthesised and are thus only available on a limited scale from natural sources. Patellin 2 and trunkamide A share a common cyclopeptide motif based upon natural rigid aminoacids, such as proline and thiazoline, and feature two unusual serine or threonine derivatives with reverse prenyl group side-chains. A solid phase approach is planned for the linear peptide, followed by either cylisation and then thioazline formation, or initial construction of the thiazoline motif followed by cyclisation. The synthesis of an aminothioacid is also required. Training content (objective, benefit and expected impact) This project will involve several areas of chemistry such as organometallic, organic and peptide synthesis, wich have become of increasing interest in both pharmaceutical and combinatorial chemistry providing ideal training for an academic position in this area (for which post-doctoral experience is essential) but also offering an attractive opportunities for an industrial career Links with industry / industrial relevance (22) Two Spanish companies, Pharma Mar (a world leader in marine source metabolites) and LIPOTEC, are strongly interested in the synthesis of patellin 2 and trunkamide A, since this will allow them to complete characterisation and therapeutic studies, focusing particularly on the fight against cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bio-inspired structural materials' (BISM).

assistant: **Concept**

The development of new technologies in areas as diverse as energy, transportation or healthcare requires new lightweight, high-performance structural materials with unprecedented combinations of strength and toughness. Unfortunately, these two properties tend to be mutually exclusive in synthetic structures. Nature, however, is very effective in designing strong and tough materials through the creation of hierarchical architectures which span multiple length-scales from atomic to macroscopic dimensions. The notion of replicating natural designs (biomimetics) has generated enormous interest but has yielded few technological advances, primarily because of the lack of processing techniques able to achieve, in practical dimensions, such complex structural hierarchy. Recent results have shown how the freezing of ceramic suspensions can be used to replicate Nature’s concept of hierarchical design and create strong ceramic-polymer materials with exceptional toughness, up to 300 times higher (in energy terms) than their constituents. The objective of the present grant is to follow this approach and create a new family of bio-inspired structural materials that will exhibit unprecedented combinations of strength and toughness. This will be achieved by combining new processing techniques based on the concept of ice templating with microstructural with mechanical characterization and modeling at multiple length scales, from the atomic to the macro levels. The work will be supported by basic studies in fields as diverse as the freezing of suspensions or mechanical behavior. The results will have significance in fields as diverse as materials science, chemistry or biology. Particular attention will be placed on the creation of bone-like ceramic-based materials for orthopedic implants
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tailoring the electrode-enzyme interface for efficient bioelectrochemical CO2 reduction by formate dehydrogenase' (BERCO2).

assistant: **Concept**

The main objective of this proposal is to optimize the enzyme-electrode interface to achieve efficient bioelectrochemical carbon dioxide (CO2) reduction by formate dehydrogenase (FDH). To achieve the overall goal of the proposed project, the specific objectives are: 1) Incorporation of an unnatural amino acid (UAA) to Molybdenum-containing FDH (Mo-FDH) such that the enzyme can be specifically and covalently attached to electrode surfaces with controlled orientation for improved electron transfer (ET) 2) Tailoring the bio-interface between electrodes and FDH H for facile electrocatalysis by direct ET (DET) or mediated ET (MET). This includes the design electrode surface with pyrene moieties/mediator for directing orientation of biocatalysts on electrode surfaces. 3) Bioelectrosynthetic CO2 capture with electrochemical systems exploiting UAA-FDH H. For this, the prepared UAA containing Mo-FDH based biocathodes will be coupled with a hydrogenase bioanode to provide a complete enzymatic biofuel cell (EBFC) producing formate (HCOO− )and simultaneously producing electrical energy from molecular hydrogen (H2) and CO2. The project will be conducted in 3 work packages associated with research objectives. An UAA will be introduced to FDH H for the first time, yielding an approach for site-specific functionalization of complex metalloenzymes with this project. The proposed technology is highly attractive because it presents a promising solution to tackle global climate issues and energy concerns by providing improved green conversion of CO2 to chemical fuels. This project will be undertaken within the group of Professor Ross Milton (University of Geneva, Switzerland) and a secondment of two months is planned with Prof. Jason Chin (MRC Laboratory of Molecular Biology, Cambridge, UK
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Solar VVC desalination plant' in the context of a Fourth Framework call.

assistant: **Objectives**

PROJECT OBJECTIVES Many attempts have been made at developing commercial solar desalination systems but no such system has materialised. The reason for this is that while technical options have been demonstrated they are too complicated or too expensive to compete with fossil fuel systems. The objective of this project is to design and build a prototype solar desalination plant that will be commercially viable and produce water at less than $2/m3. The plant will have a capacity of 750 m3/day. TECHNICAL APPROACH The approach taken is to use a desalination technology that has the lowest energy consumption and combine it with a solar thermal system that produces the least cost energy that is compatible with the desalination technology: - a commercially available vacuum vapour compression (VVC) desalination system which is normally electrically powered will be converted to run on steam at 25 bar pressure. Mechanical energy consumption can then be reduced to below 10 kWh/m3 - a fixed mirror concentrator and a tracking receiver will provide thermal power for the desalination unit. An annual solar-steam energy efficiency of 43% is predicted. EXPECTED ACHIEVEMENTS AND EXPLOITATION The system can operate in solar only or hybrid mode. The project tasks comprise: 1) Modification and testing of VVC unit to operate on steam 2) Design and testing of the heat transfer system (receiver, storage and boiler), 3)System Optimisation 4) Final Design and Construction 5) Commissioning and Monitoring and 6) Integration Issues. The most risky task is the design of the solar receiver. There are five milestones: - VVC desalination unit achieves an energy consumption less than 10 kWh/m3 - Solar receiver achieves target efficiency of 65% - Prototype is completed and produces 750 m3/day of clean wat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Galactic molecular clouds and star formation' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The study of star formation defines a central theme in modern astrophysics with relevance across the entire field, from the origins of our own Solar System and other, possibly similar systems, to the formation of the earliest galaxies in the Universe.In the next year a suite of revolutionary instruments, including the SCUBA-2 submillimetre array and the HARP-B submm heterodyne array, will begin operations on the James Clerk Maxwell Telescope (JCMT). A number of international collaborations will pursue JCMT Legacy Surveys with these instruments, thereby opening up the poorly-known submm sky to systematic study for the first time and providing the first comprehensive submm survey of star formation throughout our Galaxy.New high velocity resolution surveys of the 12CO and 13CO 1-0 lines from the Five College Radio Astronomy Observatory (FCRAO) 14m telescope have also recently been completed. FCRAO surveys now provide contiguous sub-arcminute resolution mapping of the Northern Milky Way from l=18 to l=192, while targeted FCRAO observations are available for many of the Gould's Belt clouds.At Exeter, we will perform fundamental analysis of the FCRAO and JCMT molecular line data to produce the most detailed database of molecular gas in our Galaxy yet assembled, in the form of cross-linked molecular cloud and submm ore catalogues. This will benefit the entire star formation community and establish a firm foundation for a comprehensive analysis of the JCMT Legacy data.Aside from providing kinematic distance information, spectral line data from the CO lines observed by JCMT and FCRAO probe the molecular gas substrate from which the starless and protostellar core population are forming, and define the mass, and structure, of raw material available for star formation, as well as t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bivalve conditioning and settlement – keys to competitive hatchery production' (SETTLE).

assistant: **Concept**

Hatchery production of bivalves during autumn and winter (outside natural spawning season) is a challenge, but necessary to keep market shares and ensure sufficient seed supply to European growers on a year-round basis. The SETTLE project will focus on key events during hatchery production of flat oyster (Ostrea edulis) and great scallop (Pecten maximus) which are species native to Europe. The overall objective is to foster year-round production of spat in hatcheries by controlling gonad development and maximise larval metamorphosis and settlement. Flat oyster and great scallop are both highly valued and sought-after products on the European seafood market, but insufficient numbers of high quality seed severely hamper aquaculture development of this sector. Bivalve hatcheries (SMEs) in Spain, France, Ireland and Norway are looking to increase the availability of spat and will engage RTDs in Spain, France and Norway to solve selected problems related to broodstock conditioning and larval settlement. Successful intensive production of bivalve spat depends on predictable procedures for conditioning of broodstock (manipulation with feed, light and temperature) to induce spawning, breeding period, larval rearing and settlement. To solve the seasonal problems the SETTLE project will identify environmental factors leading to successful off-season broodstock conditioning, reveal effects of conditioning and other biological processes on settlement and optimise existing culture methods and technology. By extending the hatchery production season and obtaining new knowledge and technologies the SMEs will increase the available number of flat oyster and great scallop spat. A quantity and value increase 5-10 times of today’s level is anticipated within 5-7 years. This will strengthen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'ENGINEERING AND EVALUATION OF SYST NEMATODE RESISTANCE IN SUGARBEET'.

assistant: **Objectives**

The cyst nematode Heterodera schachtii is an important pest for the sugarbeet crop in Europe.Very few effective nematicides are on the market and increasing environmental concerns will most probably result in restricting these toxic chemicals in Europe by the end of the century. Therefore, the introduction of cyst nematode resistance into @ugarbeet is a priority target for the sugarbeet companies. Since interspecific crossing-in natural resistance genes causes tremendous problems in sugarbeet, we propose the design and evaluation of a novel genetic basis for nematode resistance in plants.The proposed strategy for genetic engineering resistance to cyst nematodes in sugarbeet aims at destroying selectively the nematode-induced feeding sites (syncytia) in sugarbeet roots. Sedentary nematodes (cyst and root knot nematodes) are absolutely dependent on the formation and maintenance of plant feeding sites. The strategy requires a chimeric construct consisting of a nematode-induced plant promoter, more or less specifically active in the feeding site, and a cytotoxic gene.Several plant promoters that are activated (or down-regulated) in the feeding sites have been identified (in Arabidopsis, tomato and potato). These promoters will be tested by fusion to a reporter gene and analysis of their expression in transgenic sugarbeet roots. This will allow to confirm if the isolated promoters are strongly induced (or down-regulated) in the feeding sites of H. schachtii in sugarbeet roots.As a cytotoxic gene, the barnase gene, a natural ribonuclease gene, will be fused to the nematode-induced promoters. A second chimeric gene containing a promoter which is down-regulated fused to the barstar (an inhibitor of barnase) gene will be used to inactivate unwanted expression of the barnase gene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'SemAntically integrating Genomics with Electronic health records for Cancer CARE' to be submitted under Horizon 2020.

assistant: **Abstract**

The aim of this project is to bring together subject matter experts from the academic and non-academic sectors to create a holistic informatics platform for rapidly integrating genomic sequences, electronic health records (EHRs) and research repositories to enable personalised medicine strategies for malignant melanoma treatment.The consortium has engaged in a pre-proposal process with active clinical end users who have highlighted the need for more innovative approaches for the treatment of cancer - in particular the treatment of malignant melanoma, including inter alia the ability to rapidly query of geno-phenotype associations in melanoma such as the recently discovered rs2301641 SNP variability   with ABCB5 function and CDK4 gene indicators . Hence we aim to develop a scalable HPC framework that allows the semantic interlinking between spatially distributed electronic patients’ health records, associated genomic sequences and published research, thereby allowing clinicians to make reasoned queries over vast knowledge bases for the diagnosis, treatment and management of malignant melanoma.