RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'FOOD 2030 Flagship Conference on Research and Innovation for Food and Nutrition Security and Quality Empowerment' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

In the prospect of the discussions on proposal of the EC on the next Multiannual financial framework and the 9th Framework Program for Research and Innovation, coupled with exploring the opportunities for promoting public-private partnership for increasing the processes of inclusive participation involving actors from different sectors, the project for a Flagship conference during the Bulgarian EU Presidency intends to provide a platform for discussions on increasing the impact of R&I for the whole food chain, in response to societal needs and expectations, climate change and globalization. To do this, Bulgaria will address, invite and involve a wide diversity of actors to build a shared and inclusive vision, boosting future investments in R&I in Europe and leveraging private investments and increasing synergies with public funding.Within the overall European Research and Innovation context, this would mean maximizing the impact from R&I on industry, policy and society, and making difference for local and regional communities and enhancing their innovation potential.The focus of the conference will be on R&I for future proofed Food and Nutrition Systems. Food 2030 – Research and Innovation for Food and Nutrition Security and Quality Empowerment conference concept will be built upon the whole Food System approach, linking land and sea, producers to consumers and back to addresses the four FOOD 2030 priorities: Nutrition for healthy and sustainable diets, Climate and environmental sustainability, Circularity and resource efficiency, Innovation and empowering communities.Such decision is motivated by the accord that research and innovation are key for a better future for societies and will bring secure and competitive environment including transforming existing food system
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Next-generation Dynamic Digital EPCs for Enhanced Quality and User Awareness' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

D^2EPC ambitiously aims to set the grounds for the next generation of dynamic Energy Performance Certificates (EPCs) for buildings. The proposed framework sets its foundations on the smart-readiness level of the buildings and the corresponding data collection infrastructure and management systems. It is fed by operational data and adopts the ‘digital twin’ concept to advance Building Information Modelling, calculate a novel set of energy, environmental, financial and human comfort/ wellbeing indicators, and through them the EPC classification of the building in question. Under the project vision, the proposed indicators will render dynamic EPCs a realistic, accurate and comprehensive tool that can lead the transformation of the European building stock into zero-energy buildings and stimulate energy efficient behavioural change of the building occupants. To this direction, D^2EPC proposes a digital platform that will enable the issuance and update of new EPCs on a regular basis, integrate a GIS environment and provide, on top, value added services including user-centred recommendations for energy renovation, benchmarking and forecasting of buildings’ performance as well as performance verification services. The proposed scheme will contribute to the redefinition of EPC-related policies and to the update of current standards, along with guidance for their implementation and will introduce incentivisation and restriction practices into the EPC rationale. Additional benefits include enhanced user awareness and engagement on buildings’ energy efficiency, facilitated planning and decision making on local and regional policy level. To accomplish the above, the D^2EPC framework will be demonstrated in 6 sites, while its 12 partners coming from 7 European countries will collabor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Microbial Biomarker Records in Tibetan Peats: Monsoon Variability and its Impact on Methane Biogeochemistry' (TIBETMETH) targeting Seventh Framework.

assistant: **Abstract**

It is crucial to understand terrestrial microbial processes because they govern greenhouse gas emissions; unfortunately, the long-term microbial responses to climate change remain unclear, causing uncertainty in predictions for how they will impact future climate and atmospheric composition. The peatlands from the Tibetan Plateau, controlled by the Indian Monsoon and East Asian Monsoon systems, have been major players in climate change and carbon cycling, such that these deposits represent a truly novel potential to address the above scientific issues. This proposed research will expand the Tibetan Plateau dataset of peat-forming plant δD values, a key hydrological indicator; quantify and isotopically characterise microbial biomarkers and especially those derived from organisms involved with methane cycling; evaluate the link between precipitation, vegetation, redox conditions and microbially mediated processes and especially methanogenesis. These records will be developed using cutting edge approaches exploiting gas chromatography (GC), GC-mass spectrometry, high performance liquid chromatography-mass spectrometry, GC-isotope ratio mass spectrometry (IRMS) and GC-thermal conversion-IRMS. This dataset seeks to understand methanogenic and methanotrophic processes and will be used to develop higher resolution and longer-term CH4 biogeochemical records over the Holocene and to better understand the effect of Asian monsoon change on modern and ancient CH4 biogeochemistry, and to ultimately embed them in the framework of known and hypothesised relationships between microorganisms and climate change. This work will be one of the very first applications of these novel methodologies to the study of past changes in peat biogeochemistry outside of Northern Europe. It will validat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Lithuanian Network on Food Quality and Safety', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The present proposal aims to contribute substantially to the Integration and Strengthening of the European Research Area in the field of food safety, food quality control, knowledge-based multifunctional materials and new production processes and devices, by means of specific support actions in Lithuania. These actions will be implemented to stimulate Food Quality priority area. It will involve the screening of research establishments active in Food Quality area, promotion of Lithuanian competencies, support to Lithuanian researchers to participate in consortia building, to prepare proposals, information, awareness and training activities, prospective studies aimed at defining research policies and organisation of research systems, and most importantly the establishment of a Lithuanian Food Quality network (LIT-FQSN), and implementation of networking between the LIT-FQSN institutions, and between LIT-FQSN and four well-known, European Food Quality Research centres. The planned supporting activities will address not only cross cutting horizontal issues such as development and implementation of research and innovation strategies, trans-national technology transfer and related services, but also a wide range of other related activities to promote dissemination, information and communication activities (workshops, seminars, awards and competitions), gender issues and ethical aspects. The planned actions will be coordinated by the Lithuanian Institute of Biochemistry in close collaboration with all Lithuanian research institutes and other institutions, which are carrying out high quality research in the Food Quality field. The participating European Food Quality Centres will act not only as advisory organisations for the LIT-FQSN researchers, but will also be actively involv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Phase I/II ex vivo gene therapy clinical trial for recessive dystrophic epidermolysis bullosa using skin equivalent grafts genetically corrected with a COL7A1-encoding SIN retroviral vector' in the context of a Seventh Framework call.

assistant: **Objectives**

RDEB is one of the most severe rare genetic skin diseases of children and adults characterized by skin blistering resulting  from lack of expression of type VII collagen. There  is no treatment for this life-threatening disease. In March 2009, we obtained the orphan drug designation for the Medicinal product:  “Skin equivalent graft genetically corrected with a COL7A1-encoding SIN retroviral vector”, which was developed during the THERAPEUSKIN project (FP6) to treat RDEB patients by ex vivo gene therapy. This approach uses autologous skin grafts made of primary keratinocytes and fibroblasts  genetically corrected with a safe  (SIN) retroviral vector expressing type VII collagen under  the control of the EF1alpha promoter. We have  demonstrated the feasibility of the approach in pre-clinical  studies in mice and the absence of tumorigenicity. We now aim at preparing and undertaking a first clinical trial in 3 selected RDEB patients.This project will involve the transfer and the adaptation from the research laboratory to clinic, of the entire experimental procedure for genetic correction of RDEB skin equivalents suitable for transplantation in patients. This will include validation of the viral pilot batches and the GMP viral vector lot, the establishment of SOPs,the identification and selection of the best  GMP culture system and the scale-up of the graft preparation. A clinical-grade cell bank of primary keratinocytes and fibroblasts  will be established from 3 selected RDEB patients who are tolerant  towards type VII collagen. Determination of transgene integrity, analysis of the proliferative capacities of transduced keratinocytes and the level of type VII collagen expression will be assessed. Safety  assessment will include tumorigenicity  assays, survey  of grafted
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'SelfPOCNAD - Development of a Point of Care Detection Device and Self     Sampling Device for Cervical Cancer Screening –'.

assistant: **Objectives**

Our project is to develop a commercial pre-production prototype point of care test for invasive cervical cancer (ICC). This easy-to-use lab-on-a-chip system (SelfPOCNAD) will enable women to collect samples in the comfort of their own homes and take them into a GP surgery for testing and provision of immediate results.   This will dramatically increase compliance of women with the ICC screening programs will and drastically decrease the ICC incidence and save lives. ICC is the second most common cancer in women.  Each year, there are over 470,000 new cases globally.  Of these, 33,000 are in the EU.  Once the disease is established, it is hard to cure, so each year 233,000 women die - 15,000 in the EU[1].  After breast cancer, it is the second-most-common cancer amongst women.  However, this is a preventable and treatable disease, if detected in the early stages.  Some EU member states have well-organised screening and effective prevention programmes.  But better compliance with screening using this inexpensive lab-on-a-chip system, especially in New Member States, could save the lives of 3-5,000 European women p.a.This demonstration project will enable the SelfPOCNAD consortium to prove that they have a technological and commercially sound proposition.  It will allow them to  secure investment by either a major blue chip company or an investment house to fund the scale up to production of this life saving and commercially attractive Point of Care (POC) test.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Make-ready of an acoustic system based on transverse vibration analysis applied to NDT of mechanical performances of timber and wood based composites'.

assistant: **Innovation**

Starting from the acoustic vibration technology, the project has to perform the make-ready of NDT systems adapted to the main following markets: -Development of a system based on the use of a standard portable computer in order to obtain a commercial product costing less than 15 K ECUS for an on site use. (especially in the building sector) -Receipt controls on panels packages at the entry of the plant. -Version integrated in a production line while retaining the constraint of simplicity, soundness and an instrumentation cost inferior to 30 K ECUS. (out of supply and draining devices) The aim of the research project is to use acoustic vibration analysis techniques to grade wood based panels or timbers according their stiffness properties. It implies the verification of the grading capability and the conception of an adapted equipment. Furthermore, the prediction of defects that allows prediction of strength and also the level of internal stresses, which is a serious defect in panels production, seems to be possible. Indeed, the study of the eigenfrequencies spectrum which can be disturbed by the presence of big defects (it can be observed some eigenfrequencies shifts and peak spreading) gives information about the quality of the panel. The possibilities to exploit these perturbations is also part of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cultural diversity in Europe: a series of conferences' (EURODIV).

assistant: **Concept**

EURODIV aims to organise a series of five Conferences on the understanding of cultural diversity in Europe and the ways of dealing with diversity and its dynamics in the globalisation era. The analysis of (cultural) diversity in Europe and related issues i s now very high on the political agenda and is a most debated research area. However, the interdisciplinary feature of cultural diversity is rarely adequately reflected in the current training offer.EURODIV events stand as the only existing academic and interdisciplinary-oriented series of Conferences in the field of European cultural diversity that centres on early-stage training of researchers. The project offers a highly valuable opportunity for young researchers and leading scientists to communicate in a spirit of mutual learning, providing an organised training at the frontiers of current research.This is done by:- providing a better understanding of cultural assets and of how their diversity contributes to human welfare;- exploring cultural dialogue as a key mechanism through which cultural differences can be expressed and interact in a positive manner;- providing a better understanding of the dynamics of cultural diversity in Europe and the world in relation to the process of globalisation.Five themes have been identified to design a training and research path to improve understanding of cultural diversity: two wide Conferences (the first and last, 80-90 participants) and three thematic Conferences (30-40 participants). The three thematic events are training sessions on more specific subjects, including a knowledge-building session.The events focus on the following issues respectively:- Understanding Diversity, FEEM (6)- Diversity in Organisations: Delineating Processes and Management Practices, K .U. Leuven (1
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Comparative functional genomics of cellular signalling pathways'.

assistant: **Concept**

Cancer and many other human diseases are often caused by aberrations in cellular signalling pathways. Mutations in signalling genes have been shown to stimulate cell proliferation and migration, and ultimately leading to uncontrolled growth and metastasis. Such examples include Wnt, Hedgehog, Notch signalling pathways which are also required for proper development from invertebrates to mammals.Signal transduction pathways are essential cellular processes in development and homeostasis for every complex organism. Studies in model organisms such as C. elegans, Drosophila and mice have contributed significantly to the understanding of how cells transmit information in vivo. We have previously shown that Wnt pathways in human and Drosophila cells lead to the activation of distinct intracellular signalling routes that control cell specification, proliferation and migration. Specifically, we propose here to use cellular assays and genome-wide RNAi to systematically identify components of signalling pathways both in human cells and Drosophila cells.During the past years, we have developed methodologies to perform rapid high-throughput RNA interference screens in cell-based assays. We will use a comparative functional genomics approach that will allow us to use the advantages of a less complex invertebrate genome to comprehensively identify genes that may be missed in our parallel approaches in human cells. Identified pathway components will be further characterized using genetics, biochemical and molecular methods and will be analysed for deregulation in human cancers. These components constitute targets for drug discovery to interfere with inappropriate signalling pathway activation during disease.We envision building a team that is highly competitive at the forefront of inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Antagonizing GnRH signaling as a “holistic” therapeutic strategy for Polycystic Ovary Syndrome' (GRASP).

assistant: **Innovation**

PCOS is the most common endocrine disorder affecting up to 18% of women worldwide. The syndrome imposes a heavy health burden, covering infertility, obesity, type 2 diabetes and metabolic syndrome. The development of treatment options is an urgent need since there is currently neither a cure nor mechanism-based treatments, leaving patient management suboptimal and focused solely on symptomatic treatment. One key neuroendocrine aberration in most women with PCOS is increased luteinizing hormone (LH) pulse frequency. This suggests an increase in activity of gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. The LH hyper-pulsatility contributes to increased ovarian thecal androgen secretion and failure of ovulation, constituting a pivotal pathogenic role in the syndrome. These evidences suggest that alterations of GnRH neuronal activity/secretion could be the basis for neuroendocrine anomalies that accompany the reproductive disturbances in the syndrome. In GRASP we will test the hypothesis that low administration doses of a GnRH antagonist, aimed at tempering LH secretion/pulsatility, can ameliorate both reproductive and metabolic PCOS traits in animal models of PCOS and in women with PCOS. The specific objectives of GRASP are to i) dose-range GnRH antagonism to rectify LH pulse amplitude and frequency in PCOS-like mice ; ii) to perform a long-term treatment with the selected doses of GnRH antagonist to assess its potential beneficial outcomes in correcting reproductive and metabolic alterations of this preclinical model; iii) to perform a pilot dose-effect clinical investigation testing the ability of sub-therapeutic doses of GnRH antagonist to rectify the altered hormonal dynamics in women with PCOS.  The overall goal of GRASP is to provide a proof-of-co