RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Capturing the value of intangible assets in micro data to promote the EU's growth and competitiveness' in the context of a Horizon 2020 call.

assistant: **Objectives**

GLOBALINTO will provide new measures of intangible assets at the firm level, filling an important gap in measurement which has restricted statistical production, micro-based analysis and evidence-based policymaking. GLOBALINTO will analyse the various potential explanations of the productivity puzzle, both at micro and macro levels. Our work will bring further the earlier work by the EU FP7 Innodrive project to create refined and validated intangible capital data and indicators that can be implemented in official statistics production. Importantly, this also includes the development of measures of public sector intangibles and their impact on innovation and productivity. The analyses in GLOBALINTO are novel, focusing not only on firm behaviour at the micro level but by also being able to observe the common growth characteristics in industries and the role of intangibles for changes in market structure. Broader measurement of intangibles (in particular non-R&D) at the firm level helps to identify new sources of growth to reverse the trend of lower intangible capital deepening after financial crises in 2008. Knowledge on human and intangible capital at the firm-level also helps to promote new intangible capital formation under the ageing population. Such a micro data approach is by definition necessary also in the effort to understand the role of small firms as engines of growth and hindrances for market entry. The analysis also aims to show the global structure and fragmentation of value chains, and their role in innovation, knowledge diffusion and the exploitation of new knowledge. On the basis of empirical results and theoretical advances, GLOBALINTO will also explore and further the role of policy for the mobilisation of intangibles. The ambition of GLOBALINTO is not
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding and targeting pathogenic IgG4 responses' (IGG4-START), addressing dissemination and exploitation.

assistant: **Impact**

The predominant autoantibody (sub)class is an important determinant in the pathophysiology of autoimmune diseases (AID). Autoantibodies can be pro-inflammatory, such as IgG1, causing disease by complement-mediated or immune cell-mediated tissue damage. In 2015 I was the first to describe a second group of AID where IgG4 autoantibodies, which are largely unable to activate the immune system, cause disease. Till date at least 29 different diseases classify as IgG4-predominated AID (IgG4-AID). Why certain AID are predominated by IgG4 autoantibodies is not known, but this is confirmed to be critical for precipitation, mechanism and treatment of the disease. In fact selective permissive determinants for class switching to IgG4 in general are not known. Recently, I realized that in contrast to IgG1 autoantigens, IgG4 autoantigens are single pass transmembrane proteins which are continuously shed from the cell. I therefore hypothesize that a key element of the aetiology of IgG4-AID is IgG4-AID antigen shedding resulting in chronic, systemic antigen stimulation in the absence of ‘danger’ signals like bacterial antigens, viral antigens or cellular damage. The goal of this project is therefore to unravel the antigenic and environmental cues that initiate and drive IgG4 (autoreactive) responses following this innovative paradigm, and to find strategies to specifically reduce pathogenic IgG4 responses.I will study this hypothesis using the archetypical IgG4-AID MuSK myasthenia gravis as a model. The combination of state-of-the-art antibody technologies including human lymphoid organoids and AI-based antigen-antibody modelling, with my IgG4 autoimmunity expertise and our set of patient-derived monoclonal antibodies, puts me in an unique position to address the goal of this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Digital Technology Use and Teen Wellbeing in Context: An Ethnographic Investigation' (TecWell), addressing dissemination and exploitation.

assistant: **Impact**

The project is a comparative study of adolescent digital literacy and digital media use, using a mixed qualitative approach with an emphasis on ethnography. The rapid increase in children’s engagement with digital technologies raises questions regarding their potential impact on wellbeing. However, the data currently available to us as to this impact are largely inconclusive. This is partially due to the fact that most studies rely on quantitative measures that offer little insight into the actual content consumed, or the contexts within which engagement with media takes place. The study addresses these limitations by introducing the use of ethnographic methods to investigate the broader relational contexts within which teens’ interaction with digital media takes shape. Specifically, it investigates the relationship between two factors found to potentially impact teen wellbeing while using digital media: digital literacy, and the manners in which digital media is integrated into family life. Differences in digital literacy and family integration patterns are examined across both gender and socioeconomic divides, as well as between children who mostly consume digital media, and those who also produce digital media artifacts and contents through active engagements in spaces such as Fabrication Labs or Makerspaces. By taking a qualitative, holistic and longitudinal approach, the study aims to identify mechanisms involved in facilitating a fruitful integration of digital media into children’s lives, and to generate data needed for the development of strategies and guidelines to aid teens, parents and educators promote digital media engagement in manners that would enhance teen wellbeing.


**Keywords:** Medical Anthropology, Digital Media, Digital Literacy, Wellbeing, Famil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'System level modelling of metastasis from signalling to cell motility'.

assistant: **Objectives**

The most intriguing phenomenon in cancer research is the ability of tumour cells to spontaneously migrate away from the primary tumour and metastasize. Metastases are strongly related to poor prognosis and reduced patient survival. Therefore, studying motility properties of cancer cells may benefit the development of therapeutic methods, and can hopefully contribute to improved survival.Cancer cell motility is achieved by motility structures such as lamellipodia, filopodia and blebs. Blebs are large, round deformations of the cell, mostly driven by hydrostatic pressure that involve changes in the actomyosin cortex. While the mechanical process of bleb formation and retraction is pretty much known, its dependence on internal and external signalling is still missing. In this research we focus on the relations between signalling, blebbing and cell migration, using both experimental data and system-level modelling.The Met tyrosine kinase is an endogenous receptor that normally initiates directional motion, needed for various homeostatic tasks such as embryogenesis and wound healing. High levels of Met were shown to be related to malignancy and metastases. In the proposed research we will study Met amplifications and activating mutations, and their influence on cell shape, motility, tumourigenesis and metastasis, both in vitro and in vivo, using advanced imaging modalities.The experimental results will be used to construct a mathematical model. which couples membrane signalling to actual membrane protruding forces such as hydrostatic pressure and cortical tension, and to the overall cell motion. This allows us to learn how directional motion is achieved by apparently random blebbing and how they are both connected to cellular signalling. This model can also be used to test a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Prefrontal plasticity underpinning resilience against cognitive ageing.'.

assistant: **Concept**

As global life-expectancy increases so do pathological age-related conditions impacting cognition. The worldwide prevalence of Alzheimer’s Disease is expected to rise from 46 to 131.5 million affected people in the next 30 years, which will drastically compromise quality of life for many individuals and place a considerable economic burden on society. As acknowledged by the EU Commission, there is an imperative to ‘improve our understanding of the causes and mechanisms underlying…healthy ageing and disease. Older adults differ vastly in the extent to which their cognitive functions, such as memory, attention, and decision making remain healthy. Highlighting sources of interindividual variability in this resilience to cognitive ageing, particularly in the face of neuropathology such as Alzheimer’s Disease will enhance the development of targeted neurorehabilitation interventions to prevent and redress cognitive decline. Several lines of work indirectly indicate the right fronto-parietal network (rFPN) in the brain, particularly the dorsolateral prefrontal cortex, is critical for healthy cognition in ageing. This proposal will combine advanced cognitive neuroscience techniques to directly investigate whether neurocognitive markers of healthy ageing (i) relate to interindividual differences in white-matter (WM) structural organisation within the rFPN, and (ii) can be improved by upregulating activity within this network. This fellowship will be conducted at the Oxford Department of Experimental Psychology under the supervision of Prof Kia Nobre, world expert on the cognitive neuroscience of attention, and in close collaboration with Prof Heidi Johansen-Berg, leading authority on white matter plasticity at the Wellcome Centre for Integrative Neuroimaging (WIN).


**Keywords
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Foods for diabetes and cognition' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

FODIAC aims to develop a dietary solution to tackle type 2 diabetes and cognitive dysfunction of the elderly. FODIAC will enhance the quality of R&I in Europe, promoting cooperation along the Food Value Chain. This is achieved through advanced international, intersectoral, cooperation between 7 academic and 8 industry partners. For this purpose, FODIAC assembles a European multi/interdisciplinary consortium, composed of partners in 5 countries that provide expertise in: extraction and purification of bioactive molecules, nanotechnology, nano/micro-encapsulation, toxicology, nutrition, biomarkers, clinical trial management. Rationale: lack of knowledge sharing among academia and industry  acts as a barrier for the development of functional foods for the elderly, who represent one of the fastest-growing population segments worldwide. Approach and Outcomes: FODIAC coordinates the actions of individual partners, academic and industrial, using Exchange of Staff as a tool to capitalize on complementary competences to: i) conduct joint research; ii) protect the Intellectual Property based on this research; iii) foster the transference of the generated knowledge, skills, and technology to the industrial sector; and iv) exploit research output to the benefit of society. FODIAC’s outcomes will include: i) an increase in the R&I capacity among participating partners; ii) boosting of knowledge transfer of emerging micro/nano-biotechnologies from academia to industry, to develop cost-effective processes; iii) commercialization of new functional ingredients and functional foods containing antidiabetic and cognitive-enhancing bioactive molecules; iv) acceleration of the development of dietary recommendations and interventions based on those products, to improve the quality of life of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PeRsOnalized DocUmentary Creation based on Automatically Annotated Content' in the context of a Horizon 2020 call.

assistant: **Objectives**

Recent market research has revealed a globally growing interest on documentaries both from the demand and supply side. Documentary genre has now become the 2nd most populated content-wise genre in the movie titles catalog, surpassing traditionally popular genres such as comedy or adventure films. At the same time modern audiences appear willing to immerse into more interactive and personalised viewing experiences, through second-screen content and advanced video formats such as 360° video. Documentaries, even in their linear version, involve high costs in all phases (pre-production, production, post-production) due to certain inefficiencies, partly attributed to the lack of scientifically-proven cost-effective ICT tools. PRODUCER aims at filling this gap, by delivering a set of innovative ICT tools that focus on supporting various stages of the documentary creation process, ranging from the user engagement and audience building, to the final documentary delivery. Apart from the key objective of reducing the overall production cost and time, enabling small documentary production houses (SMEs) to increase their market share and competitiveness, our project would result in: a) providing greater creativity and productivity to documentary creation professionals, stimulated by new production sophisticated tools that enable searching, annotating, editing, personalizing professional and user generated content, b) enhancing viewers’ experience and satisfaction by generating multi-layered documentaries, and delivering to the viewer personalized services, and c) facilitating the promotion of the documentaries to investors. The consortium is composed of three SME partners, one broadcaster, one large ICT industry, and two research institutions, all of them actively involved as key a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Improving bioproduction through dynamic regulation circuits' (BioCircus) targeting Horizon Europe.

assistant: **Abstract**

Biological production of chemicals and materials is a renewable and economically viable alternative to the current chemical processes, easing the transition towards a biology-based circular economy. The current biomanufacturing industry faces a scalability problem. Frequently, producer strains created in the laboratory do not respond well to industrial conditions (e.g., large fermentation volumes, accumulation of toxic intermediates, media acidification, etc.). The goal of BioCircus is to address the issue caused by the lack of robustness of the engineered microbial strains. BioCircus is based on three main research pillars: (1) the construction of biosensor and dynamic regulation circuits that measure and control the production of the target molecule, (2) the use of machine learning predictive models and automation to improve these circuits and (3) validating the designed strains in pre-industrial conditions, closer than standard molecular biology laboratory procedures to real-world bioproduction operations. Naringenin, a key molecule of the flavonoid family, will be used in as proof-of-principle molecule. E. coli will be used as model organism. The design and construction of biosensors and dynamic regulation circuits controlling naringenin production is expected to support the development of methodologies and tools suitable for any other detectable metabolite. BioCircus will produce academic and industrial impacts that will boost the bioproduction field by enabling a shorter strain time-to-market for a wide variety of adaptive and scalable microbial bioproducer strains.


**Keywords:** biosensors, dynamic regulation, engineering biology, scalable bioproduction, automation, machine learning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sublinear Optimization for Machine Learning' in the context of a Seventh Framework call.

assistant: **Objectives**

The explosion of data with the expansion of the World Wide Web, social networking and e-commerce is a ripe opportunity for smart data analysis and machine learning on a scale never before encountered. In many applications, making even a few passes over the data is prohibitive. Our research goal is to develop sublinear time optimization algorithms for data analysis and machine learning, i.e. algorithms that do not observe all the data even once, and yet return a provably correct solution with high probability.Previous research of the PI, conducted mainly at Princeton University and IBM Research, has produced promising preliminary results. This proposal aims to expand this line of research at the host institution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Separation Technology for A Million Peaks' (STAMP) under Horizon 2020.

assistant: **Objectives**

Extremely high separation powers are required to fully characterize complex mixtures that are of crucial importance in many fields, such as life science (including systems biology), food science, renewable energy sources and feedstocks, and high-tech materials. The STAMP project is aimed at obtaining a peak capacity of one million in liquid-phase analytical separations. Spatial three-dimensional liquid chromatography will be used to achieve this goal. The major advantage of this technique is that all second-dimension separations and – in a next step – all third-dimension separations are performed in parallel. This allows high-resolution separations to be performed in each dimension, while the total analysis time remains reasonable. Optical and mass-spectrometric imaging techniques are envisaged as detection methods after printing (STAMPing) the effluent from the 3D separation body on a suitable substrate. The STAMP project also has a number of sub-targets that will bring additional significant benefits to all the above application fields.  The target and the sub-targets of the STAMP project may be summarized as follows.• Separations with a peak capacity of 1,000,000 (through the use of spatial 3D-LC)• Fast and efficient spatial 2D-LC separations• Devices for spatial 2D-LC and 3D-LC• Detection principles for spatial 2D-LC and 3D-LC• Suitable stationary-phase materials and mechanisms for orthogonal 2D and 3D separations• Relevant applications of all of the above in various fields of science.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Key insights into oxidation chemistry through synthetic systems: N2O activation with first-row transition-metals and O2 activation in heterobimetallic Fe-Ni systems' (NEWOXMET).

assistant: **Innovation**

Oxidation reactions are one of the most important chemical transformations applied both in bulk and fine chemistry. In nature, this type of reactions is catalyzed by metalloenzymes which can perform highly selective transformations under mild conditions. Several bioinspired model systems have been developed but key issues remain to be successfully developed both from the catalysis point of view and also from the fundamental understanding of key reaction intermediates. In this project, we will tackle two of these topics.Activation of N2O with first-row transition-metals: nitrous oxide (N2O) is a greenhouse gas but it also constitutes an environmentally friendly alternative to the traditional oxidants used nowadays as it only generates N2 as waste. Despite being thermodynamically a potent oxidant, N2O is kinetically very stable. However, these kinetic barriers can be overcome through activation by suitable metal centers. In the present proposal we will activate N2O with mononuclear first-row transition metal complexes. The prospective species derived from this process will be used as oxidants for the selective oxidation of organic substrates.Fe-Ni heterobimetallic systems involved in O2 activation: heterobimetallic-O2 intermediates are of interest due to the possible “synergistic” effect of two different metal ions acting together. In addition, O2 activation at heterobimetallic complexes will result in novel chemical species distinct from homometallic species, and therefore they will exhibit new oxidation reactivity patterns that could eventually translate into novel selectivity. Here, we pursue the synthesis of heterobimetallic complexes involved in O2 activation combining iron and nickel. These species are prepared by reaction of a well-characterized and thermally stabl