RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dynamically loaded filament wound composite parts tailored for hot and wet environments', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

One of the most challenging tasks of composite design is to predict durability. This means that composite structures must be designed to maintain strength and stiffness throughout their service life in order to prevent excessive maintenance, repair or modification costs. However, due to the lack of proper models and experimental data, the designer is often faced with an impossible task. This is a controlling feature for the general use of modern engineering composites which leads, many times, to uneconomical structures. The industrial objective of this project is to construct proper tools to design dynamically loaded filament wound composites which have adequate durability when subjected to high-cycle fatigue and/or hostile environments. This issue is of major importance for industry because filament winding provides a very inexpensive way to manufacture composite laminates. For example a modern paper machine uses many rolls subjected to high cycle fatigue. These components are often also subjected to environmental spectra including moisture, high temperatures and corrosive agents. In detail, the main industrial objectives can be achieved by the following developments: 1. New simulation models for estimating the lifetime of composite structures in hostile environments. 2. New production technologies to obtain structures with the pre-calculated, optimised laminate configuration as well as producing a void free material. 3. New quality control systems in order to ensure the structures are produced as near as possible to the optimum model. 4. New methods to obtain information concerning internal stresses present within a composite structure. 5. Innovative resin compositions having optimum long-term strength properties in hot and wet environments by application of new addit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multi-scale and Multi-physics Modelling of Soft Tissues' (MULTI-SOFT) targeting Horizon Europe.

assistant: **Abstract**

Mechanics exerts significant influence on biological growth, development, and disease through multi-physical factors and at multi scales. Current modelling research in cancer growth, spreading and morphogenesis lags far behind experimental studies, and this gap has seriously hindered cancer diagnosis and treatment. The advanced mathematical and computational modelling of soft tissue and cancer-related phenomena, combined with systematic experimental studies and robust numerical simulations, are of great research significance to the health and economic values of Europe.The main goal of the MULTI-SOFT project is to overcome these challenges in an original and innovative manner by developing multi-scale and multi-physics modelling of soft tissues to improve our understanding of cancer and develop tools for its identification and treatment. The work will be approached from theoretical, computational, and experimental perspectives based on the applicant's and host laboratory's expertise. The training program is exhaustive and will allow the applicant to grow as an independent researcher. The proposed research will foster further development in this direction, a step that is fundamental in healthcare and for the benefit of society. The applicant is a Chinese scholar with expertise in the areas of applied mathematics, solid mechanics, soft matter, instability and bifurcation, and multi-filed coupling. He has been trained in prestigious academic institutions in China, Ireland, and the UK. He publishes articles in high-impact factor and top journals, at the frontiers of applied mathematics, biomechanics, and other disciplines. He is requesting funds for two years, to work with Prof. Davide Bigoni and his Solid and Structural Mechanics Group at the University of Trento, Italy, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Wind Hybrid Evolution for Low-Carbon Solutions'.

assistant: **Innovation**

The overall objective of the WHEEL project is to fully demonstrate and bring to a precommercial Technology Readiness Level (TRL) a revolutionary floating wind technology excellently suited for deep water locations, effective industrialization strategies, breakthrough cost reduction and minimized carbon footprint. This shall enable a radical step forward for LCoE reduction, whilst also addressing scalability, harbour infrastructure suitability and availability, and the sustainability & circularity of floating offshore wind.  Development and demonstration needed to reach the pursued TRL will be achieved through the design, installation, certification and testing of a fully operative 6MW Pilot unit, which will showcase and demonstrate the breakthrough advantages that the WHEEL technology can deliver to the floating wind industry. It will be installed in a deep-water location in the PLOCAN testing area (Canary Islands, Spain), where it shall be thoroughly monitored along a period sufficient to underpin the commercialization and bankability of the technology. The WHEEL project pulls together a Consortium of renowned European companies and research institutions with extensive experience and a spearhead position in the renewables and marine industry. This multidisciplinary team joins forces to complete the full demonstration of such a disruptive technology by integrating complementary expertise fields and capabilities which effectively cover all key areas of floating wind systems in pursuit of the ambitious objectives of the project.


**Keywords:** floating, wind energy, atlantic, circular economy, sustainability
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Centre of excellence: institute of experimental medicine, prague' (1998-2002).

assistant: **Concept**

Founded in 1975, the Institute of Experimental Medicine is a member of the biomedical group of research institutes of the Academy of Sciences of the Czech Republic, whose scientific orientation is towards basic research in biomedicine. The eight departments of the Institute currently focus on several main areas of research for which the Institute is recognised as the leading centre in the Czech Republic: Cell Biology and Ultra structure, Neuroscience, Molecular Epidemiology and Teratology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European project of obstetric haemorrhage reduction: attitudes, trial, and early warning system', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

This project aims both to decrease the prevalence of severe obstetric haemorrhage and to improve management when it occurs. A global five steps has been taken tithe problem. The five steps of the project are the following:(i) Description of current level of agreement and actual clinical practice(ii) Establishment of European" guidelines(iii) Randomised trial of effectiveness of routine measurement of blood loss with graduated collector sac,(iv) Internet consensus and "early warning" list for professionals,(v) Internet platform for women and families to gain information and exchange experiences."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Detection of endpoints and biomarkers of repeated dose toxicity using in vitro systems' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Assessment of repeated dose toxicity is a standard requirement in human safety evaluation and relies on animal testing as no alternatives are currently accepted for regulatory purposes. An integrated research strategy for the replacement of animal tests needs to comprise the development of biomarkers of long-term toxicity in human target cells. To this aim, the DETECTIVE project will set up a screening pipeline of high content, high throughput as well as classical functional and “-omics” technologies to identify and investigate human biomarkers in cellular models for repeated dose in vitro testing. In view of industrial use in automated high throughput systems, essential questions of repeated dose toxicity such as stability and robustness of readouts will be investigated in a first phase. This will be the foundation for innovative biomarker development based on integration of multiple data streams derived from “-omics” readouts with traditional toxicological and histopathological endpoint evaluation. Toxicity pathways identified in “-omics” readouts can thus be further investigated by the functional readouts.DETECTIVE will initially use human hepatic, cardiac and renal models as common target organs of repeated dose toxicity. Ultimately, the strategy for establishing biomarkers will also be applicable to other organs or organ systems affected by systemic toxicants. It is also expected that DETECTIVE will be able to define human toxicity pathways relevant for all organs.Based on integrative statistical analysis, systematic verification and correlation with in vivo data, the most relevant, highly specific, sensitive and predictive biomarkers will be selected. Within DETECTIVE, partners from academia, industry and research will hence generate pathway- and evidence-based un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Locomotor issues in Parkinsonian's Mesencephalic Locomotor Region and Subthalamic nucleus' (LINKERS), addressing dissemination and exploitation.

assistant: **Impact**

Parkinson disease (PD) is the most common movement disorder. Dysfunction of basal ganglia circuits in PD leads to characteristic motor deficits including bradykinesia, with hypometria and reduced EMG activity, tremor, and frequently gait disorders with start hesitation or freezing of gait (FOG) associated with increased falling. On the one hand, there is a large literature on the postural adjustments during gait initiation and the biomechanics of ongoing gait in healthy and patient populations. On the other hand, neuronal recording in the pallidum, subthalamic nucleus (STN), substantia nigra pars reticulata (SNpr) and mesencephalic locomotor region (MLR) demonstrate activity related to movement and locomotion in rats, cats, primates and humans. DBS, particularly STN- and MLR-DBS, can effectively alleviate postural and locomotor deficits in PD, although the neural mechanisms and the precise role of each structure in locomotion is still matter of debate. The aim of this study is to characterize the association between STN and MLR neuronal activity and the biomechanical parameters of locomotion and gait initiation. I will characterize these associations in PD patients using neuro-muscular, neuro-kinematic and neuro-neuronal (STN-STN, MLR-MLR) coherence in different locomotor paradigms under different treatment conditions. This study will make an important contribution to a poorly studied but important aspect of motor control in PD. From a knowledge transfer point of view, it will provide important information to clinicians and researchers using DBS to ameliorate postural difficulties and FOG. From an interdisciplinary point of view, it will help neurologists to refine diagnosis as well as foster the core of knowledge and help targeting new avenues of treatment to rehabilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DEmystifying Targets in Endothelial Cells for anti-Tumor Immunity improVEments' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Despite significant medical advancements, cancer remains a major cause of mortality worldwide, and several cancer types still lack efficient therapy, in part due to resistance to traditional immunotherapy (IT). Endothelial cells (ECs) present an important yet overlooked modulator of tumor immunity, possessing an immunosuppressive nature, and proposed to contribute to IT resistance. Studies of the host lab indeed identified immunomodulatory features in EC subsets (coined IMECs). My central hypothesis is that targeting immunosuppressive (IMMUSUP) genes in tumor ECs may promote anti-tumor immune reaction to overcome resistance and improve the efficacy of traditional IT. The aim of this work is to identify novel, IMMUSUP genes expressed by tumor ECs and assess the potential of targeting these genes in vivo to promote anti-tumor immune response. I will explore in particular mystery genes (with poor functional annotation, ca 1/3 of the mammalian coding genome and an unexplored resource of potential targets) to maximize the identification of novel IMMUSUP genes beyond the currently used targets in traditional IT. Thus, I will (i) identify and prioritize EC IMMUSUP genes using artificial intelligence/machine learning approaches and (ii) in silico bioinformatics coupled to a mystery-genome wide siRNA screen to reveal IMMUSUP activity; (iii) confirm IMMUSUP targets via lipid nanoparticle-based siRNA delivery to generate EC-specific knockdown mice in models of lung, esophageal, and liver cancer; and (iv) determine the Mode of Action of the most promising targets using multidisciplinary approaches. My work will yield insights about previously unknown drug targets in tumor ECs, potentially paving the way for development of alternative IT with enhanced efficacy. My prior experience i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DECiphering the seismic signature Of aseismic DEformation' to be submitted under Horizon Europe.

assistant: **Abstract**

Earthquakes are a major threat to humankind, causing damage above 500 billion USD and more than 400,000 fatalities within the last 20 years. Nonetheless, the generation of large earthquakes remains poorly understood. Recent research suggests that the key to deciphering this preparatory phase lies in the complex interplay of seismic and aseismic processes. Three event types are of genuine interest: slow slip events (SSEs), which are episodic aseismic deformations; low-frequency earthquakes (LFEs), a type of earthquake depleted in high-frequency energy; and regular earthquakes.A key factor limiting the understanding of the seismic-aseismic interplay are incomplete LFE catalogs, caused by the difficulty to detect these events. Therefore, in this project I will develop a novel detection method for LFEs building on recent advances in deep learning. Applying this method, I will compile comprehensive catalogs for three regions: Northern Chile, Nankai (Japan) and Nicoya (Costa Rica). These catalogs, in conjunction with continuous geodetic records, SSE catalogs and seismicity catalogs, will allow me to study the seismic-aseismic interplay. This will reveal physical driving mechanisms of the seismic-aseismic interplay and give insights into the preparation of large earthquakes. This will contribute towards the accurate assessment of seismic hazard and the preparedness for seismic events.I will conduct this project at the Université Grenoble Alpes, with a secondment at the Massachusetts Institute of Technology. My scientific background in interdisciplinary research between deep learning and seismology, is complemented by my supervisiors: Anne Socquet, expert on aseismic processes and subduction zones; and William Frank, expert in the detection and characterisation of LFEs. The pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Risks of occupational vibration exposures' (VIBRISKS) under Fifth Framework.

assistant: **Objectives**

VIBRISKS will advance understanding of injuries from hand-transmitted vibration and whole-body vibration by epidemiological studies and laboratory research. The work will enhance primary prevention (technical and administrative controls) and inform secondary prevention (health surveillance, reducing exposure in affected workers). VIBRISKS includes: (I) study of dose-response and natural history of disease from occupational exposures to vibration; (ii) studies of risk in exposed populations where the consequences are uncertain; and (iii) laboratory studies to support the epidemiological investigations (improved measures of exposure, inclusion of important confounding factors, e.g. postural stressors). The coordinated programme of research provides the scale of study and diversity of expertise required to advance understanding of the complex relationships between vibration and disorders, and provide practical guidance on health surveillance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Template grown molecular nanomaterials'.

assistant: **Objectives**

Nanoscience has emerged as an important frontier for fundamental advances in the chemical and physical sciences. This RTN is designed to bring together and co-ordinate an interdisciplinary team whose members each contribute separate areas of expertise relevant to the objectives of the scientific programme. These objectives are to establish and improve the synthesis of interesting new nano materials, with unprecedented properties, via template based processes. In order to evaluate the new nanomaterials a range of physical methods need to be applied and developed. This RTN brings together teams with expertise spanning many areas of synthesis and characterization of nanomaterials. For example single walled carbon nanotubes have been shown to be an exceptionally versatile template for the synthesis of nano crystalline materials and this area will clearly lead to advances in the fundamental understanding of the structures and properties of new low-dimensional namomaterials. The challenge of detailed characterisation of the physical and chemical properties of the new nanomaterials will in turn lead to development of new methodologies. For example, the application of image restoration processes in high-resolution transmission electron microscopy has already proved to be exceptionally valuable for structural characterization. Other state-of-the-art techniques in which the network has expertise will be utilized to gain understanding into the structures and properties of these new materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'BioAhead – an innovative optimization algorithm for amino acid chain analytics' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Globosoft GmbH aims to optimize the drug development process of drug manufacturers, enabling faster and more efficient development of drugs in Europe and worldwide. For this purpose, Globosoft GmbH has developed the innovative optimization algorithm called BioAhead to optimize acid chain analysis, as part of the protein structure modeling field. The innovation will create growth in terms of income and new job creation and have a high return on investment. The proposed model has a high potential for a fast up-take by the market, considering the savings in time and money and also a cloud technology that will make the model easy-to-use in any country. BioAhead adequately addresses issues related to the society. With faster and more accurate drug development processes, the society in Europe and world-wide can benefit from low- priced medicines, faster drug development and highly specialized medicines, which are currently too expensive for economic development.