RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Stem cell riboregulation: a new layer to control self-renewal, differentiation and metabolism' to be submitted under Horizon Europe.

assistant: **Abstract**

Although multiple regulatory layers have been reported to control stem cell differentiation, including epigenetics, cell signaling and metabolism, we still lack sufficient knowledge on how differentiation processes are connected and coordinated. The Hentze laboratory recently discovered that RNA modulates (riboregulates) the activity of the glycolytic enzyme Enolase 1 (ENO1) and that this interaction is essential for in vitro murine embryonic stem cell differentiation. Additionally, unpublished data from the laboratory show that the glycolytic enzyme pyruvate kinase (PKM) is also riboregulated. However, the role of riboregulation during primary stem cell differentiation remains elusive. Previously, RNA-bound proteomes have either been identified in cultured cells or ex vivo in whole organs. I aim to investigate enzyme-RNA interactions in primary stem cells and differentiated progeny, using the hematopoietic system as a model. First, I will analyze the RNA-binding activity of previously in cellulo profiled enzymes ENO1 and PKM in vivo and ex vivo during hematopoietic stem cell (HSC) differentiation by RNA-proximity ligation assays, profiling of stem cell activity and transcriptome analysis (aim 1). Secondly, I will analyze, identify and comparatively quantify global RNA-protein interactions in HSCs, progenitors and mature blood cells by developing a method to profile in vivo RNA-protein interactions (aim 2). In an interdisciplinary approach, I will pair fluorescence-activated cell sorting with state-of-the-art RNA-protein cross-linking approaches and ultra-low input proteomics analysis. The generated data will help, for the first time, to understand at the analytical and functional level whether and to what degree riboregulation of enzymes represents a regulatory paradig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Construction of Aqueous-soluble Ruthenium Catalysis for Asymmetric Synthesis' (CARCAS) under Sixth Framework.

assistant: **Objectives**

Development of catalyst-based processes is critical for creating sustainable technology. One such class of reactions, olefin-metathesis mediated by transition metal complexes has recently emerged as a vital tool for organic synthesis. Besides the creation of organic polymers through ring-opening, a new methodology involving tandem synthesis offers a facile route to macrocyclic systems, which now comprise many new pharmaceutical agents. Ruthenium-alkylidene complexes of the Grubbs and Hoydeia variety perform efficient metathesis for a diverse variety of substrates with high functional group tolerance. However, are three main problems encountered with olefin metathesis by these types of complexes, namely, low-yielding asymmetric synthesis, unpredictable cycloisomerization, and inefficient operation under aqueous conditions. The latter has become necessary in order to prepare high molecular weight biological targets. To address these problems, a Ru-based catalyst based on the N,N-chelating ligand, beta-diketiminate, is proposed. Advantages of this ligand include easy and high yielding preparative procedures with flexibility to attach a variety of substituents, including water-soluble functionalities. Furthermore, possibilities exist to create a chiral ligand for promoting asymmetric reactions. Anchoring of the catalyst through attachment of the ligand framework to a solid state support would facilitate high-throughput screening of substrates and assist in the rapid identification of problematic cases. The conditions which promote cycloisomerization over olefin metathesis will also be investigated. Structural data from single crystal X-ray diffraction studies combined with models calculated by the combination of density functional theory and molecular mechanics will help to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for '3D Printing of Pyrolytic and Graphitic Carbon', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

3D printing of carbon materials has significantly impacted several research fields, including energy, electronics, transport, health, and space. Particularly in tissue engineering applications, it promises the fabrication of patient-specific personalized scaffolds, offering a suitable combination of essential properties. However, several challenges remain in the marriage of 3D printing and carbon materials. Two of the current challenges are little control in the properties of 3D printed pyrolytic carbon (3DPyC) and the complex fabrication process of 3D graphitized carbon (3DGC). Therefore, even though preliminary studies show good cytocompatibility of 3DPyC and 3DGC, a proper investigation of the cell-carbon interaction, essential for tissue engineering applications, cannot be reliably performed. The 3D-Carbon project aims to solve these two challenges by developing a pathway to reliably control the micro and macro-structural properties of 3DPyC and introducing a facile fabrication approach for 3DGC. These will be achieved through synthesizing customizable functionalized green precursor materials suitable for stereolithographic 3D printing and controlled pyrolysis. Cell culturing within 3D printed carbon scaffolds with controlled properties will further allow us to have a better understanding of the cell-carbon interaction, which could, therefore, lastingly impact innovation on carbon scaffolds for tissue engineering applications. Furthermore, such a study will lead us to the future development of carbon-based engineered living materials.


**Keywords:** Carbon, 3D printing, Pyrolysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Universal regulatory library for any cell type'.

assistant: **Concept**

DNA synthesis technology has greatly developed over recent years, serving a growing multi-billion synthetic DNA market. Synthetic DNA is used in projects that optimize reagents, chemicals, crops and other organisms, in projects seeking to increase the manufacturing efficiency for the above, as well as in studies of molecular regulation and other cellular processes. The latter is the focus of the MRG-GRammar H2020 FET project. As part of the results of MRG-Grammar, we have developed a universal regulatory library that is made of binding sites motifs that have been shown to be highly active in every cell type that we have tested from yeast to mammalians. The library is synthesized with a new composite-base technology that was also developed in MRG-Grammar. In this study, we propose to explore the application space for the universal library and resultant market potential. Requested funding will be used to complete the universal library proto-type and to demonstrate that expression of a biologic can be optimized with this tool. In addition, we will explore a potential service model, business model, and a licensing mechanism for the dissemination of the universal library for various stake-holders in the academia and private sectors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Vuvxiii' (VUVXIII).

assistant: **Innovation**

The VUV conferences bring together experimentalists and theoreticians in the field of physics, chemistry, biophysics, biochemistry and related research fields from universities, research laboratories and industry and attract leading scientists from Europe, America and Asia currently contributing to state-of-art development of the particular aspect of the field under study. It is organised with a significant number of key and invited lectures from leading international experts and several hundred presentations distributed in parallel sessions.A vitally important aspect of the VUV conferences is that they serve as effective media for (i) dissemination of recent achievements and relevant new developments in specific fields, (ii) raising scientific interests of young researchers and establish contacts with acknowledged experts and company representatives, (iii) encouraging the young researchers to move to new and potentially rewarding domains.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Building collaborative networks for new product development'.

assistant: **Objectives**

This research project seeks to examine the building of internal and external networks for new product development by evaluating and comparing such practices in three European countries UK, Denmark and Germany. The aim is to identify the key socio-economic factors involved in shaping collaborative product innovation and to highlight broader European policy implications of such activities. Special attention will be paid to the social processes through which 'network builders' form, develop, and sustain internal/external collaborative networking and the manner in which policy interventions might be directed to support these activities. The research will investigate examples of new product development and focus on three interrelated themes and their policy implications: (a) The formation and development of internal collaborative networks within enterprises. (b) The formation and development of external collaborative networks in interaction withinternal collaborative activity. (c) The roles of 'network builders' in forming, developing and sustaining internal and external collaborative activities. The work programme will involve comparisons of collaborative product development networks within three contrasting European national settings. The unit of analysis will be the 'product development network' rather than a single firm, though clearly one firm is very likely to be at the focal point of each network. In each country at least three networks will be studied in one or more industrial sectors. A case study approach with semi-structured interviews of all relevant participants will be used. The aim will be to increase the understanding of the diversity of collaborative practices within the enterprise as well as at sectoral and regional levels. The project will deliver a final
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Hybrid Photocapacitors for Ambient Light Applications' under Horizon 2020.

assistant: **Concept**

The sustainable future of humankind will be possible through energy use optimization, enabled by billions of Internet of things (IoT) devices. In this proposal, I will design an innovative device architecture for energy-autonomous IoT devices, namely Photocapacitor for Ambient Light (PHOTALA), which will be specifically adapted to indoor-light harvesting. The PHOTALA is constituted of 1) a hybrid photovoltaic joined to 2) an electrical double-layer supercapacitor (EDLC) based on the family of polyviologens. Ambient-light offers universally available energy, normally ranging from 100 to 500 lux, which is sufficient to supply the low power densities needed by IoTs. Photovoltaic devices can harvest this energy and use it to design near-perpetual smart IoTs. Hybrid solar cells (HSCs), such as dye-sensitized solar cells (DSC), and perovskite (PSC) solar cells, are a family of emerging photovoltaics with promising properties. DSCs have demonstrated to be one of the best technologies for ambient-light harvesting, outperforming silicon and thin-film technologies. DSCs can be tailored to match the spectra of indoor lightning, and operate at high voltages under low light using copper-based redox mediators. The polyviologen supercapacitor will store intermittent energy with fast charge–discharge steps, high specific power and long-life cycles, successfully providing energy during dark periods. This fellowship will enable a ground-breaking path in the design of self-powered wireless electronic devices, and will enable the researcher to bring together previous knowledge and expertise to the host institution and obtain new knowledge in the field of coordination chemistry, nanotechnology and computer science together with other transferable skills.


**Keywords:** Ambient light photov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'A General Toolkit for “GPUtilisation” in SME Applications'.

assistant: **Objectives**

The recent explosion of GPU (Graphical Processing Unit) power has not been fully utilised by many SMEs, possibly because GPU programming requires specialist skills different from those of conventional programming. GPSME will provide the SME participants  with a simple route to accessing GPU power.Each of the SME participants is facing increasing competition in the market and GPSME will allow them to greatly improve their products in terms of speed and quality without major overheads. By involving close cooperation between the SMEs and RTD performers, GPSME will develop a toolkit to automate the conversion of existing sequential CPU code to an optimal GPU implementation. With such a toolkit, the SMEs will be able to convert their existing CPU code without committing significant effort and time. It will also support the execution of advanced techniques within acceptable runtimes and hence allow the SMEs to use more complex computing models in their new products. This will bring them major commercial benefits and significantly improve their market positions.Technically, GPSME features techniques to adapt automatic parallelization to the latest GPU compute architecture to deliver optimal performance. This is expected to greatly improve on traditional CPU-based automatic parallelization. The literature review has suggested that the techniques in this area are still very much in their infancy and that there is no existing toolkit that can benefit the SMEs immediately.The application areas of the SME participants are widely differing, so GPSME will produce a breakthrough that will open the door for great performance gains across many areas of application. This development will be particularly suitable for SMEs that focus applications on moderate platforms. In the long term, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Realizing the political rights of persons with disabilities' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Taking as its point of departure the adoption of the UN Convention on the rights of persons with disabilities the fellowship – Realizing the political rights of persons with disabilities (PODI) – examines under which conditions disabled people’s organisations are most likely to achieve voice and influence on decision-making processes of importance for their own lives and for society as a whole. The United Nations Convention on the Rights of Persons with Disabilities requires state parties, and the EU, to ‘closely consult with and actively involve persons with disabilities’, notably ‘through their representative organizations’. Enhancement of opportunities for disabled people’s organisations to fully participate in policy process will assist the EU in furthering its wider ambitions to engage civil society, and to fulfil its international treaty obligations to the UN on disability rights. The fellowship –will produce new knowledge to help make this a reality. It will launch the first cross-national and multilevel study of disability movements in Europe, beginning with in-depth data from four European countries (Germany, Italy, Norway and UK), and from EU and UN institutions. PODI will collect and analyse data on individual and organisational level as well as at national, EU and international level. PODI will identify implementation facilitators and barriers and make proposals for indicators to aid the EU and the Member States in monitoring their fulfilment of the UNCRPD (Articles 4.3, 29 & 33). A European centre of excellence (the Centre for Disability Studies at the University of Leeds, UK) will collaborate with an experienced researcher (Dr Rune Halvorsen, Norway) and civil society organisations of persons with disabilities (via the European Disability Forum) for inters
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Self-Healing Hydrogels for Material-Assisted Cell therapy in Osteoarthritis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Osteoarthritis (OA) is an incurable and painful disease. Over 70 million Europeans are currently affected by OA – a number that is set to increase with aging population and prevalence of obesity. To date, no clinically-efficient therapy exists to treat this socioeconomically debilitating disease. In this context, innovative regenerative therapies for joints are a pressing medical challenge.Intraarticular mesenchymal stromal cell (MSC) injections hold the great promise of stopping and reversing age-associated inflammation and degeneration of joints by providing the necessary trophic factors to mitigate immune responses. However, translational progress using conventional cell delivery (saline) has been seriously hampered by the limited control over cell survival, location and fate in damaged joints. It is now common knowledge that cell microenvironment plays a crucial role in the success of cell transplantation; and appropriate synthetic matrix design is key to success.To address challenges in intraarticular MSC-based immunomodulation strategies, we have envisioned an original hydrogel-assisted cell therapy. In this strategy, an injectable hyaluronic acid (HA)-based hydrogel with long-lasting viscoelastic properties will allow MSC encapsulation and cytoprotection, ensuring the production of anti-OA soluble factors in vivo. To best mimic synovial environment and support MSCs in vivo, we will synthesize a novel boronic acid-based, self-healing HA hydrogel with unique properties of injectability, stability and fast relaxation under mechanical load.After carefully characterizing the physicochemical properties of this new class of biomaterials, we will investigate the effects of cell encapsulation on adipose stromal cell (ASC) survival, morphology and factor secretion. Then, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The role of neutrophils and their proteases in the pathology of allergic airway disease' (NEUPROTALL).

assistant: **Innovation**

Asthma is an active area of respiratory research due to its impact on morbidity and mortality worldwide. The limited treatment options available to severe asthmatics represent a great challenge. Severe asthma is associated with neutrophilia but the role of neutrophils in this pathology remains poorly defined. A greater understanding of the role of neutrophil proteases will lead to the development of novel avenues for therapy.This project provides a unique opportunity to define the role of neutrophils and their proteases in directing the cellular inflammation and pulmonary remodelling in a clinically relevant model of allergen induced airway disease. I will combine established murine models of house dust mite-induced asthma and expertise in neutrophil/protease biology to address key questions on this unmet need for the first time. I will define the contribution of neutrophils to the development of pulmonary inflammation and structural changes due to HDM, to what extent are neutrophils responsible for the pulmonary protease imbalance in the allergic lung and the roles of their proteases and matrikines, and I will address how do neutrophils alter the homeostatic regulatory pathways within the lung. I will enhance my expertise gaining a comprehensive understanding and hands-on experience of in vivo models of asthma and complex downstream analysis by flow cytometry, mass spectrometry and microarrays, benefitting from the internationally renowned experience of the host groups. My current expertise in respiratory diseases coupled with a capacity to readily assimilate new knowledge and skill sets provides me with the ideal platform to address and successfully execute the project.This project will provide key tools for understanding the role of neutrophils in asthma, contributin