RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding cellular mechanisms of human brain development using cerebral organoids' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The development of the human brain is a key and fascinating question in neurobiology. Studies in model organisms have provided enormous insight into basic mechanisms of neurogenesis, which relies on the balance between proliferation and differentiation of neural stem cells. Although human neurogenesis follows the same principles, human specific processes that lead to human brain expansion are largely unclear. In vitro models that recapitulate human brain development are invaluable tools to provide insight into human specific processes and brain expansion. In this application, I propose to use human cerebral organoids, a novel in vitro model system of human brain development, to investigate human specific mechanisms of brain development.Studies in primates suggest that the orientation of the mitotic spindle in neural stem cell divisions may be a key factor driving the expansion of the human brain. In order to gain insight into the role of spindle orientation in human brain development, I will use cerebral organoids to investigate how changes in spindle orientation affect proliferation of human neural stem cells and their differentiation into neural fates. To induce changes in spindle orientation in cerebral organoids, I will inactivate known regulators of spindle orientation. For this, I will establish an inducible loss-of-function system in human embryonic stem cells to inactivate such regulators in a controlled manner during the development of cerebral organoids. By using live-imaging techniques in such organoids, I will analyse how changes in spindle orientation affect the outcome of neural stem cell divisions. Then, by using immunohistochemical analysis, I will examine how changes in spindle orientation influence neuronal layering and cortical architecture. Overall,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Colouring the Dark in Fluorescence Light' to be submitted under Horizon Europe.

assistant: **Abstract**

Abstract The radical vision of CoDaFlight (Colouring the Dark in Fluorescence light) is the development of a next-generation imaging platform capable of revealing in real-time new and more accurate information related to a patient’s body and its diseases through an innovative time-domain fluorescence imaging (tdFLI) technology. Real-time imaging of fluorescence lifetime, deep into the patient, permits the unlocking of rich information, where today’s medical imaging systems remain in the dark. This novel, breakthrough technology is expected to find in first instance broad applicability during medical surgery, where it will influence intraoperative decision-making on a per patient basis. The consortium encompasses unique, complementary and multidisciplinary expertise, by bringing electronic and biomedical engineers, physicists, chemists, medical scientists and medical doctors together. In a multidisciplinary, holistic approach they allow both parallel and integrated research progression, on semiconductor image sensors, mathematical algorithms, fluorescent dyes, and biological proof of concepts under medical guidance. CoDaFlight will kickstart a new biomedical research field, the development of new solutions towards unmet clinical needs and addresses the growing need for safe diagnostic tools that can interrogate molecular and/or physiological parameters in real-time for immediate feedback during medical interventions or for continuous health monitoring. The objectives of CoDaFlight are to develop the technological foundations that are needed to enable real-time in vivo tdFLI in medical practice and to integrate these foundations into a complete working imaging system. CoDaFight will demonstrate and disseminate the capabilities and potentials of this novel technology throu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Capability building for research and development in traditional fermented African dairy products' (1994-1998).

assistant: **Concept**

The main objectives are as follows:* To upgrade the quality of dairy research in Africa by promoting co-operative research and networking among African scientist and dairy technologists.* To phenotypically and genotypically characterize the microflora desired for the production of traditional sour milk and yoghurt and to explore their probiotic properties.* To identify and characterize the dominant lactic acid bacteria responsible for the fermentation of traditional sour milk and yoghurt and determine their suitability for use as starter culture.* To upgrade traditional dairy fermentation technology to semi-industrial scale production using selected cultures as well as improved processing layout and equipment design to ensure product safety, quality and stability.Expected Outcome* Generation of information on microbiological, biochemical and nutritional and probiotic aspects of traditional fermented dairy products could lead to the selection and tailoring of microorganisms which could be used as starter cultures for the controlled fermentation of fresh milk in order to improve the quality, safety and shelf life of dairy products.* The application of GMP practices to traditional fermented dairy products will lead to a reduction in risks of foodborne intoxications and infections that can be encountered in dairy products.* Local technological capacities will be strengthened by the establishment of a network for scientific co-operation among African food scientists.The key activities envisaged are:* Comprehensive national reviews of research on dairy products including literature reviews and evaluation of previous scientific works. Publication of a regional review report and an annotated bibliography on fermented traditional dairy products.* Characterization of dominant mic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Networks of Trade and Religion in Richard Hakluyt's 'Principal Navigations'' under Seventh Framework.

assistant: **Concept**

This proposal will enhance the career development of the IEF through a research project that engages with Richard Hakluyt’s 'Principal Navigations' the most important collection of early modern English travel writing. The project will introduce a more sophisticated understanding of religious identity into the discussion of Hakluyt and his sources. In light of recent research on religious identity formation, we can no longer label Hakluyt as simply a staunch Protestant when he featured material from those of other faiths and his anti-Catholic rhetoric simply reflected state policy. The second objective is to re-establish the centrality of global trade to Hakluyt’s vision. Scholars have devoted disproportionate attention to the material relating to the Americas despite the fact that it comprises just one third of the Principal Navigations. The majority of the text is devoted to trading ventures. These overlooked voyages to Russia, Turkey and Persia will form the heart of this project. The project will be interdisciplinary in engaging with aspects of early modern trade, religion, culture and literature. It will also be interdisciplinary in blending methodologies of textual analysis with prosopography and social network theory. Outputs will be a monograph alongside open access digital resources in the form of a prosopographical database and collection of biographies. Research will be disseminated also through conference organization and participation. An outreach programme in schools will help to create lasting dialogue between the university and local community, whilst helping students become proficient in the use of digital resources and creating a future generation of researchers equipped with transferable skills. It will enable the IEF to enhance their contribution to t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of sensitive methodologies for exploitation of early epigenetic marker diagnosis in major types of cancer' (EPIDIACAN), addressing dissemination and exploitation.

assistant: **Impact**

Cancer is one of the major causes of mortality. Epithelial cells become malignant after accumulating genetic mutations followed by morphological changes in the epithelium. DNA Alterations include stable genetic changes in oncogenes, tumor suppressor genes and reversible epigenetic changes. Different forms of epigenetic mechanisms have been shown to modify the expression of key genes during tumour progression. Promoter DNA hypermethylation of tumour suppressor genes or DNA repair genes, and covalent histone modifications appear in early stages of neoplasia. Methods to identify early markers in different types of cancer are being developed, although very few are specific and sensitive enough to be applied in the clinic. The aim of the present proposal is to develop sensitive and specific methodologies to identify early epigenetic markers for major types of cancer, like prostate and colorectal cancer. This project is based on recent findings that selected covalent histone modifications and their modifying enzymes can be early markers of tumourigenesis. For this purpose, the following will be applied. a) selected covalent histone modification like acetylation, methylation, phosphorylation, ubiquitination among others b) their modifying enzymes, like DNA (de)methylases and histone (de)acetylases, (de)methyltransferases c) appropriate diagnostic methods and tests for detection of selected markers in clinical samples.  These markers are revealed from studies in cell and animal models as well from patient cohorts. Non-invasive diagnostic methods based on technologies developed in the participating organizations will be tested in clinical samples. Appropriately selected clinical samples will be utilized according to EU and national ethical procedures. The major task of this cons
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Tackling the Cyclacene Challenge' (TACY) targeting Horizon Europe.

assistant: **Abstract**

Cyclacenes, i.e., cyclic versions of acenes consisting of linearly fused benzene rings, were first discussed in 1954 by Heilbronner, but -  despite considerable synthetic efforts over decades - have remained an elusive class of compounds. Theoretical investigations suggest that cyclacenes are highly reactive due to pronounced polyradical character and significant ring strain. All prior attempts to synthesise cyclacenes failed, mainly because the final synthetic step of establishing a fully conjugated π-system was energetically prohibitive. Despite these challenges, cyclacenes remain intriguing synthetic targets because of their unique chemical, electronic, and structural properties as well as their potential applications in organic (opto-)electronics or spintronics. In this collaborative project, we will develop novel synthetic approaches, which synergistically combine efficient and high-yielding synthetic strategies of belt-type precursors that we will transform to cyclacenes by extrusion of suitable leaving groups under cryogenic matrix isolation conditions, on surfaces, in the solid state, and ultimately even in solution. Our synthetic approach is highly modular and allows to structurally vary the belt-type precursors, and thus the cyclacenes, by placing different substituents at the rims, including peri-annulation or isosteric substitution of CH units by heteroatoms. This research, combined with state-of-the-art computational investigations and characterization even on the single-molecule level, will provide unprecedented insight into the structure-property relationship of the fully conjugated zigzag topology present in cyclacenes and address fundamental questions of chemical reactivity and the interplay of aromaticity, strain and polyradical character. This knowled
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Problem-based learning trajectories in discrete mathematics education' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Our research project is inscribed into the domain of mathematics education (didactic of mathematics): a research domain at the interface of mathematics and social sciences. The project is based on the collaboration of three researchers: Katalin Gosztonyi as Experienced Researcher, assistant professor at the Eötvös Loránd University of Budapest; Viviane Durand-Guerrier as Principal Supervisor, emeritus professor at the University of Montpellier; and Simon Modeste as Co-Supervisor, assistant professor at the University of Montpellier. Our project is focused on the development and analysis of complex problem-networks which will then serve for the conception and implementation of problem-based teaching trajectories. We aim to develop an efficient modelling framework in order to construct, analyse and represent problem-networks and problem-based trajectories for mathematics education – both for research purposes and for supporting teachers’ work in planning their teaching processes. We focus more particularly on problem-networks and teaching trajectories in the domain of discrete mathematics: on their potential place and role in mathematics curricula; their values for conceptual learning as well as for the development of generic mathematical skills (related to problem solving, abstraction, proof etc); and their potential connections with other mathematical domains, including links between mathematics and computer science. A theoretical and epistemological work and a priori didactical analysis of examples of problem-networks will be combined with experimental research on teachers’ and students’ work with problem-networks. The theoretical background of the project combines theories of the didactics of mathematics from the French research tradition with current research on the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ENHANCING BIODIVERSITY AND SOCIAL INCLUSION BY TRANSFORMING EUROPE’S LIVING ENVIRONMENTS' (INNATURE).

assistant: **Innovation**

Nature Based Solutions (NBS) can support biodiversity, human health and well-being, climate adaptation and resilience, and can reduce pollution and climate change. In reality, many NBS fail to maximise these benefits or do not work over time, exacerbated by a lack of community involvement.  The INNATURE project ambition is to change this and to deliver five diverse demonstration cases across Europe that maximise NBS co-benefits and that will demonstrate best ‘next practices’ in design solutions and processes and upscaling and acceleration of NBS in different contexts. It will do so by bringing biodiversity and people diversity together at all levels (i.e. diverse communities, artists and designers, ecologists, researchers, policy-makers, other stakeholders) and thereby reimagining new (biodiverse, social, cultural and ecological) futures. The New European Bauhaus (NEB) will act as a foundation for the co-production of NBS and all of the INNATURE NBS actions will be NEB ‘by design’, thereby transforming and diversifying existing living environments that will demonstrate how NBS solutions can be inclusive, resilient and adaptable to changes, affecting policy and changing mindsets.  More specifically, the INNATURE project will: (1) co-produce and demonstrate NBS that are NEB (New European Bauhaus) ‘by design’ through Eco-Social Living Labs.(2) protect, celebrate and enhance existing local biodiversity through Art Conversations and collaboration and biodiversity actions with local ecologists.(3) ensure long-term resilience of the NBS through a Holistic Monitoring and Evaluation Framework (including citizen science), facilitated by an Integrated Digital Platform.(4) use NBS to re-imagine new living futures in Europe and create a Local Community Economy-Ecology Value Framewor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Language contact and heterogeneity in the Hybrid Chinese dialects in North-West China'.

assistant: **Objectives**

This project focusses on highly endangered hybrid Chinese dialects spoken in the Gansu-Qinghai aera, namely Wutun, Zhoutun, Gangou, Xining, Linxia and Tangwang, which are reputed to have been highly “Altaicised”. The main objective is to determine their position within the North-Western branch by identifying the different strata of Altaic influence found on the morphonological level. It aims at demonstrating the high degree of heterogeneity of certain specific features that are reputed to have been induced by contact with Mongolic and Turkic languages, namely nominal case markers, pronominal forms (third person and demonstratives) , and tense and aspectual markers. As several Mongolic languages are spoken by different minorities in this region, many scholars thought that these non-Sinitic traits have been induced through contacts with these populations and that a linguistic area has formed, leading to their areal diffusion. However, many of those are also found in dialects that have not been in direct contact with Altaic languages in recent time, including those spoken along the Yellow river spread between the Shanxi and Shaanxi regions. Therefore, a certain continuity between the dialects of these 2 regions exists, while secondary influence of Mongolic languages has further developed the changes in those dialects. By comparing this selection of forms, the project will 1. Document the typological diversity found in the hybrid Chinese dialects of the Gansu-Qinghai area (suggesting different source of borrowing or a different reanalysis process) 2. Link the contact-induced traits and forms identified in the Gansu-Qinghai hybrid dialects with those of the dialects spoken in he Shaanxi-Shanxi region. 3. Identify the different strata of Altaic influence in the hybrid dialect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Reduced Models for Motion in Fluctuating Nonequilibrium Media: Evaluating Energy Transport and Predicting Transition Rates in Steadily Driven Systems' to be submitted under Horizon Europe.

assistant: **Abstract**

The project RedNeq aims for powerful reduced descriptions of nonequilibrium media, including suspensions of active matter or of steadily driven particles, by benchmarking the fluctuation dynamics of test particles immersed in them.  The first goal is to characterize the dynamics of these probes via extended and general Fluctuaton-Dissipation relations, which can be treated as a recipe for writing Langevin equations for probes in nonequilibrium baths. That reduced dynamical description of nonequilibria is essential for the study of at least two other classes of phenomena that are envisioned in RedNeq: (i) Energy and particle transport between nonequilibrium baths, as relevant in Physics of Life systems such as biological power houses, molecular motors and bio-engines more generally; (ii) Metastability in and around steady nonequilibria from effective  nonequilibrium reaction-rate formulae, as for example important in the evaluation of dynamical large deviations, first-passage times and tipping points.The focus is theoretical and foundational for the construction of nonequilibrium statistical mechanics and soft condensed matter, with the core models, techniques, and methodologies being from stochastic processes, graph theory and path-space integration. The results of the project will be closely aligned and helpful for the ongoing biophysics ands soft matter experiments involving calorimetry and microrheology, since it will provide generalized guidlines and ready to use formulas for noise friction relations, athermal energy conductivities, and transition rates, when dealing with nonequilibrium baths.


**Keywords:** Nonequilibrium statistical physics, Response theory, Local detailed balance, Reduced description, Active particles, Stochastic process, Fluctuation theory