RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Research of new marine inhibitors targeted against desease-relevant proteins kinases' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Project OCEANCHArCoT – OCEAN CHemodiversity Against Cell cycle Targets.Protein Kinases (PKs) are involved in various human pathologies such as cancer, neurodegenerative diseases or can be targeted to alter the life cycle of various parasites such as those responsible neglected parasitic diseases such as leishmaniasis and malaria. There are no physiological events not involving significant changes in protein phosphorylation. Therefore, PKs constitute currently the first class of targets used by pharmaceutical companies for the characterization of novel bioactive compounds. In a project intended to exploit the ocean biodiversity, Jean-Baptiste Charcot (1867-1936), a pioneer in oceanography established large collections of marine organisms. Taking this one step further, my project aims to source marine crude extracts from the Nature Bank collection (Queensland, Australia), and from the unique Roscoff Culture Collection of microalgae (France) to identify new PK inhibitors. We will focus our analysis on PKs involved in the control of the cell division cycle (CDKs, TLKs and mitotic kinases such as Haspin and Auroras). The cellular effect of the selected inhibitors will be analysed on various cancer cell lines. This project will benefit from a new cutting edge technology will be used for the early screening of marine chemodiversity: bioaffinity (focused on PKs) mass spectrometry with a Bruker SolariX 12 Tesla FTMS. The lead-like enhanced fractions will be tested against various disease models and dereplicated in order to quickly identify bioactive molecules. Hit fractions will be produced in larger quantity before purification, characterization and pharmacological evaluation. In conclusion, OCEANCHArCoT will contribute, from Australia to France, to the research of marine bioac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Interactions between the marine environment, predators, and prey: implications for sustainable sandeel fisheries' to be submitted under Fifth Framework.

assistant: **Abstract**

OBJECTIVES AND EXPECTED ACHIEVEMENTSThe industrial sandeel fishery is the largest single fishery in the North Sea. Sandeels are major prey for top-predators such as seabirds. Severe ecosystem effects of sandeel stock collapses might have occurred, but the fishing industry contests the view that its activities negatively affect top-predators.Earlier studies on ecosystem effects have focused on the geographical overlap between feeding areas of seabirds and sandeels, but the relationship between prey density and availability to predators is still poorly understood. In this project, predator-prey in marine ecosystems are studied in unprecedented detail using advanced technology. Threshold values of prey density will be established under which feeding is not feasible.The knowledge obtained within this project should suffice to give fishery managers high quality advice with respect to exploitation strategies that mitigate the impact on top-predators of the marine foodweb.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Power conversion from low heat temperature with a new supercritical engine ('SUPER-C')'.

assistant: **Concept**

Low temperature engines are an obvious choice for power generation, but there are few suitable machines The Supercritical Power Converter from Slovakia generates electricity from waste heat, and solar energy. It uses dense phase fluids to achieve conversion efficiencies of 10% (>60% of Carnot) and produce electricity for less than E0.05/kWh Low grade heat is a carbon free source of electricity. A 10% conversion of existing industrial waste heat would save 70PJ/yr of primary energy, the equivalent of 4mill ton/yr of CO2, with a market worth of Euro250 mill. The solar potential is larger than this. the project will investigate a 0.5-&kW version of the engine in market specific applications. The partners will verify the product concept and determine the path to commercial exploitation. From the results the partners can establish engine manufacture in Slovakia in 2002.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'WIND TURBINE VERGNET GEV 16/75 : A NEW WIND TURBINE WITH ARTICULATED BLADES', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The aim of this project is to test and validate the new VERGNET GEV 16/75 wind turbine equipped with an innovating and economic (1100 FRF per unit) epoxy blade articulation, on a particularly windy (9.41 m/s) site of La Desirade, FWI.This major innovation, compared to current GEV 15/60, has permitted to lower investment cost by 25% by increasing productivity, and operating cost by 12%, by increasing lifespan of major components.It also allows significant lowering of noise level (by 3db(A)). It will be tested on four GEV 16/75, on extreme site of La Desirade, regularly subject to hurricanes and tropical storms.The demonstration of the essential contribution of this innovating disposition will be realised in real conditions : suppression of the effects of bending moments, flutter, of twist movements, of gyroscopic moments and of transmission of blades vibrations to the rest of the machine.This new machine comes within the scope of Vergnet's conception, that is to say :- light machine,- various applications,- simple,- of lowest maintenance,- can be lowered for maintenance and in case of cyclones.Its target price is 4500 FRF/kW machine or 8000 FRF/kW installed anywhere in the world, that is to say 25% reduction on cost of systems currently available on difficult sites in this power range.The project consists in installing 4 of these new performant wind turbines, connected to the grid on the site of Vergnet wind farm of La Désirade in Guadeloupe (This wind farm has been realized in 1992 with the help of the European Commission).This project benefits from various favourable elements :- an innovating construction with epoxy blades articulations, which allows to increase both power and life span of the wind turbine GEV 15/60 (15 m diameter, 60 kW, 13.5 m/s) up to more than 25%
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Integrated Computational Model Framework for the Study of Atherosclerosis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Atherosclerosis, a disease of large- and medium-size arteries, is the major cause of death in most of the Western world. The blood flow and its interaction with the arterial wall deformation are considered to play a significant role in the pathobiological mechanisms (i.e. LDL concentraton) involved in the process of atheroma formation. Therefore, a unified computational model framework is proposed herein, which integrates blood flow dynamics and arterial wall mechanics, and based on the findings, it aims at describing the biological events that trigger the atherogenic process and its progression, through the study of LDL transport. It is believed that such an integrated computational model framework will provide a better understanding of the pathobiology of the disease and the underlying biological processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ecological intensification in horticulture: Increasing crop quantity and quality by understanding relationships between functional diversity, ecosystem services and genotype-specific traits.' (ECO-INTENS-HORT) targeting Horizon Europe.

assistant: **Abstract**

Biodiversity is a vital resource for humanity, providing essential ecosystem services for food production. Agriculture is a main driver of biodiversity loss, thus jeopardising the biodiversity-based ecosystem functions and services agriculture itself depends upon. The demand for agricultural products is rising, so alternatives to conventional intensification are urgently needed. Ecological intensification strengthens natural processes through regulating and supporting ecosystem services instead of using human-produced inputs. Current research on temperate and tropical crops indicates that many crop systems experience pollination deficits, limiting crop production. Effective pollinators have been identified for some crops, but we lack a mechanistic understanding of how functional biodiversity translates to gene flow across plantations, and thus crop yield and quality. How floral traits of different crop genotypes affect gene flow has also received little to no attention. This interdisciplinary project is designed to create species-specific data showing how pollinator species move pollen, and which genotype(s) of pollen they carry, as this determines yield and nutritional quality. Further, this project is dedicated to assessing whether mixed cropping of genotypes can affect pollination services by measuring genotype-specific floral traits and associating traits with variation in pollinator visitations. This will create a mechanistic understanding of pollinator movement, necessary to develop ecological intensification strategies that use genotypes with specific flower traits to strategically attract and retain the most efficient pollinators. The outcome of this research has scientific, economic, and societal impact, by delivering strategies to make food systems more produc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Adaptive edge/cloud compute and network continuum over a heterogeneous sparse edge infrastructure to support nextgen applications' to be submitted under Horizon 2020.

assistant: **Abstract**

There is an increasing number of signs that the edge computing concept is going to play a dominant role in the forthcoming technology developments, disrupting economies at a large scale. The big cloud providers promptly jumped in to get the lion’s share but edge computing is intrinsically more “democratic” than cloud computing. In fact, its distributed and localized nature can be an antibody for big trusts, if properly exploited. Synergistically employing edge computing with upcoming technologies such as 5G provides an opportunity for EU to capitalize on its local resource and infrastructure and its SME-dominated application development landscape and achieve an edge-computing-driven disruption with a local business scope. To this end, ACCORDION establishes an opportunistic approach in bringing together edge resource/infrastructures (public clouds, on-premise infrastructures, telco resources, even end-devices) in pools defined in terms of latency, that can support NextGen application requirements. To mitigate the expectation that these pools will be “sparse”, providing low availability guarantees, ACCORDION will intelligently orchestrate the compute & network continuum formed between edge and public clouds, using the latter as a capacitor. Deployment decisions will be taken also based on privacy, security, cost, time and resource type criteria. The slow adoption rate of novel technological concepts from the EU SMEs will be tackled though an application framework, that will leverage DevOps and SecOps to facilitate the transition to the ACCORDION system. With a strong emphasis on European edge computing efforts (MEC, OSM) and 3 highly anticipated NextGen applications on collaborative VR, multiplayer mobile- and cloud-gaming, brought by the involved end users, ACCORDION is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Phospholipid metabolism, a novel target for antimalarial drugs - development of the pharmacological model' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The main objective of the project is the development of new antimalarial drugs that interact with the malarial parasite phospholipid metabolism and could provide a solution to P. falciparum polychemoresistant malaria.Although there is no indication of potential resistance to date, we believe that we must actively initiate studies concerning mechanisms that could be involved in potential acquisition of resistance to the effectors. This molecular approach is worth immediate investigation since precise mechanisms can be expected from the suspected drug site. Results could lead to the knowledge of a whole set of metabolic pathways vital for parasite growth. The main objectives will be to synthesize new series of original and potentially alternative compounds aimed at improving tolerance and oral absorption. Identification, isolation and characterization of the pharmacological target. To carry out thorough antimalarial activity studies including chemosensitivity, therapeutic index after in vivo oral formulations in P. falciparum-infected monkeys, and against others stages (non erythrocytic) or species (e.g. P. vivax). To describe the pharmacokinetic properties and toxic evaluation of lead compounds will also be studied. Experimental induction of resistances, characterisation of effector-resistant P. falciparum malaria and alternative to resistance. In case of resistance, combinations with other current approaches would be studied.Expected OutcomeThe work content is totally devoted to the establishment of a new pharmacological model. Although the outcome of fundamental and experimental research can never be known in advance, the numerous complementary experimental approaches that are planned within the different partner laboratories, should allow to reach the proposed objecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Industrialisation of Jet Noise Prediction Methods' (INSPiRE) targeting Horizon 2020.

assistant: **Abstract**

The project, entitled ""Industrialisation of Jet Noise Prediction Methods"" (INSPiRE), addresses fully the scope outlined in Topic JTI-CS2-2015-CFP02-ENG-03-02 ""Jet Noise Reduction Using Predictive Methods"".Turbulence-resolving CFD coupled to efficient far-field integration methods is established as an accurate means for the prediction of isolated jet noise. The trend towards increasing fan diameters however leads to the growing importance of installation effects, such as jet-flap interaction noise.The simulation of such effects however requires numerous developments in the underlying numerical approaches to achieve increased computational efficiency, flexibility and reduced user burden. Such improvements will be developed, implemented and validated for complex installed jet flows (including configurations with noise-reducing design features) within the INSPiRE project.Together with comprehensive best practice guidelines, the developments will make a significant contribution to improving confidence in simulation methods and to achieving industrial exploitation of turbulence-resolving approaches. This is furthermore ensured by the implementation and validation of methods directly in the HYDRA software.High cost-efficiency and low technical risk of the INSPiRE project is facilitated by the input of advanced methods and best practice developed within the framework of previous and ongoing projects, both European and nationally-funded.A strong and positive impact is foreseen, both towards the challenging noise reduction goals set in the renewed ACARE SRIA, as well as towards the Horizon 2020 pillar of building industrial leadership in Europe. Clear perspectives for the exploitation of INSPiRE results, both by the European aero engine OEM sector and by the SME coordinator,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Diagnostic approaches to chimerism testing after allogenic stem cell transplantation for early detection of graft rejection and relapse: technical development, standardization, and european coordinated clinical implementation (EUROCHIMERISM' to be submitted under Fifth Framework.

assistant: **Abstract**

Transplantation of haematopoietic stem cells from related or unrelated donors is becoming an increasingly important approach to treatment of different malignant and non-malignant disorders. There is thus growing demand for clinical diagnostic methodologies permitting the surveillance of donor- and recipient-derived hemopoiesis (=chimerism) during the post transplant period. The techniques currently used are very heterogeneous, rendering uniform evaluation and comparison of diagnostic results between centres difficult. International efforts aimed at the development of standardized methods are therefore urgently needed. We intend to establish a diagnostic standard for the monitoring of chimerism after allogeneic stem cell transplantation (SCT). Leading laboratories in this field from 10 European countries will collaborate to develop and standardize a molecular diagnostic assay meeting stringent quality criteria that could be adopted at all diagnostic centres involved. Implementation of international consensus criteria for appropriate investigation of chimerism after allogeneic SCT will provide a basis for optimum diagnostic support for clinical decision-making.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Networked Embedded System middleware for heterogeneous physical devices in a distributed architecture' (HYDRA), addressing dissemination and exploitation.

assistant: **Impact**

Producers of devices and components are increasingly facing the need for networking their own and complementary products in order to provide higher value-added solutions for their customers or because citizen centred demands require much more focus on intelligent solutions where the complexity is hidden behind user-friendly interfaces to promote Inclusion.Given the enormous amount of heterogeneous devices, sensors and actuators with embedded systems already existing in the market, the diversity of the producers and manufactures, the different clock speed of the deployed technologies (from several decades to some months), there is a very large need for technologies and tools that easily can add, implement and exploit the intelligence embedded in the devices. The goal for the producers is to be able to build cost-efficient ambient intelligence systems with optimal performance, high confidence, reduced time to market and faster deployment and still build on the enormous assets of the installed base.Due to fast changing user environments of mobile users, ambient services and applications adapt to changing local and environmental sets of accessible sensors and actuators, and must piece together partial states of internal and situational available knowledge. When the user moves around interacting with any private device and public surrounding computers, it's the right information that must follow her migrating from different hosts in changing environments.The main objective of the project is to develop a platform for ambient computing supporting the self-adaptive interplay of different components, not only sensors but also modelling components, controlling components implementing the application logic, and actuators. The present project proposal for HYDRA proposes to address