RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'LAsers for Applications at Accelerators: A Marie Curie Initial Training NETwork'.

assistant: **Concept**

The advancement of science and engineering in the past decades is inherently linked to the development of lasers. Ever higher laser beam powers, brightness and shorter pulse lengths have helped establish them as an invaluable tool for both a wide range of industry and medical applications, such as for example material treatment, precision measurements, laser cutting, display technologies, and  laser surgery, and for fundamental research, where many of the most advanced experiments in astrophysics, atomic, molecular and optical physics, as well as in plasma research would be impossible without the latest laser technology.Moreover, lasers have become increasingly important for the successful operation and continuous optimization of particle accelerators: Laser-based particle sources are well suited for delivering the highest quality ion and electron beams, laser acceleration has demonstrated unprecedented accelerating gradients and might be an alternative for conventional particle accelerators in the future, and without laser-based beam diagnostics it would not be possible to unravel the characteristics of many complex particle beams.The LA3-NET consortium proposes to develop laser applications for particle accelerators within an initial training network. The network brings together research centers, universities, and industry partners to jointly train the next generation of researchers. The partners aim at developing long term collaboration and links between the involved teams across sectors and disciplinary boundaries and to thus help defining improved research and training standards in this multi-faceted field
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High Efficient, Single-Use-Bioreactor simulating mammalian tissue conditions for expression and proliferation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

A unique combination of earlier EU funded projects allow four research SME´s to create a combined most visionary and innovative product for improved health. There is a strategic decision from pharmaceutical companies and hospitals for:1. continues expressing of biologicals to fulfill the expectation to “personalized medicine” and 2. proliferation of cells to support therapeutic applications and 3. proliferation of stem cells to prepare manufacturing of real “human spareparts”. Advanced process control inside tailor made and cell harboring scaffolds integrated in a High-Efficient-Single-Use-Bioreactor simulating mammalian tissue conditions will fulfill this requirements
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Stress-Induced Hypertension and the Role of the Neuroimmune System' in the context of a Seventh Framework call.

assistant: **Objectives**

Hypertension is a major health concern because it markedly increases risk of death from stroke, atherosclerosis, and other diseases.  An important environmental risk factor that contributes to the development and sustainment of hypertension is psychological stress. Given that the daily life in Western society has become increasingly stressful, a continued rise in stress-related diseases, including hypertension, is highly likely.  It has become increasingly clear that inflammation and immune cell activation are fundamental to its development.  In particular, T lymphocytes have been shown to play an important role in the pathophysiology of hypertension and more recently in psychological stress and depression related disabilities.  Therefore, further understanding of the adaptive immune response and the underlying neuroimmune mechanism(s) in stress-related hypertension is warranted. In the proposed studies we plan to investigate the role of the adaptive immune response in stress-induced hypertension and to further characterize the underlying neurocircuitry in the brain.  Using Cre-lox technology, we plan to use genetically modified mice that will allow us to specifically identify stress hormone producing cells in blood pressure control regions of the brain.  In addition, we plan to delete genes such as the angiotensin II type 1a (AT1a) receptor in neurons that produce stress hormones, such as corticotropin releasing factor. These studies will provide new information for the central and peripheral mechanisms that mediate inflammatory diseases such as hypertension and may provide a better understanding for the link between the negative impact of stress on hypertension and cardiovascular disease development.  The combined expertise from the host university in the pathophysiol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New improved orthopedical implants with laser processed bioactive coatings' to be submitted under Fourth Framework.

assistant: **Abstract**

A longer lasting, cost reduced and better osteointegrable orthopaedic knee implant has been developed. The work performed on the application of high power laser surface processing methods has delivered a calcium phosphate coating that shows a graded interface layer between the Ti substrate and the coating consisting of calcium titanate, which provides a good bonding. At the outermost surface the coating composition is hydroxylapatite and its glassy phase. Such a well adhered bioactive coating should promote faster and better osteointegration of implants for bone substitution.Various processing routes have been explored with two different high power lasers, namely the CO2 and the Nd:YAG laser. The most successful process has been the Nd:YAG laser surface cladding. A patent has already been granted.A sol-gel process has been developed to produce CaP powder specially suited for laser processing. In compliance to ASTM designation it is a high purity material with crystallinity greater than 99 % and Ca/P ratio of 1.67.Cost reduction of the implant has been obtained by the introduction of a simpler design and instrumentation together with the use of fully automated 3-dimensional CAD/CAM and Real-Virtual-Real Technologies to fully analytically model, simulate and automate the design and manufacturing of the prosthesis and its coating. Design of 4 sizes of all parts of the knee prosthesis has been completed, and a 15% reduction in the cost of the surgical instrumentation has been achieved.The prototype of the automated machine was completed and commissioned at the laser-processing site. The CAD model of the design of the knee prosthesis has been added to the simulation display software in order that the part is articulated in reality on the positioning system by simply moving t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mass Customisation of the ceramic and glass decoration. A contribution to the Future Manufacturing Industries.' (CUSTOCER) targeting Sixth Framework.

assistant: **Abstract**

Ojectives:Product customisation.A computer tool will be developed for the client to generate his own product design via the Internet; confirmation will then automatically commission production, thus providing fully customised service. Development of a prototype for decoration by application of an industrially feasible laser. Prototypes will be based on one or several laser techniques, classified in two groups:deposition and activation techniques. In the former, decoration occurs by depositing colouring materials on the surface of the fired ceramic tile and glass. The laser fuses the colorants and incorporates them into the surface, producing the design. Deposition occurs beforehand by a digital printing system. In another deposition technique the laser head itself feeds the material, with parallel fusion or cladding". In the activation techniques, decoration is by changing surface colour by exposure to laser radiation. In both techniques, the development of colouring materials and optimum glaze compositions is critical. Production optimisation. Tile decoration is customised by so-called "third-fire" manufacture, tiles fired by conventional techniques are decorated and then re-fired. Third fire requires relatively large production lots to be cost effective, thus limiting production of small customised orders.Decoration by laser technology will eliminate this last firing stage, reduce energy costs and gas emissions, and enable making small fully customised lots. It will also greatly reduce factory work space with the envisaged prototypes. In glass and ceramic tiles manufacture, organic colouring materials are mainly used for decoration, which are a source of pollutants and potential VOCs. The techniques envisaged will enable eliminating these. With regard to laser techniq
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Proteomics Research Infrastructure Maximising knowledge EXchange and access (XS)'.

assistant: **Innovation**

Genome sequencing initiated a new age in biology. Now, the emphasis is on the biological interpretation of the genome: zooming on the biological functioning of the gene-products, i.e. the proteins, emerging into a filed termed proteomics. Protein levels depend not only on mRNA levels, but also on translational controls & regulated degradation, making the measurement of expression at the protein level a prerequisite. The expression levels of all proteins, their modifications, localization and interactions, provide the most relevant single data set characterizing a biological system.The PRIME-XS consortium aims to provide state-of-the-art proteomics technologies to the European biological and biomedical research community. Its twelve partners, all leading in the field of proteomics, will provide access to their technology at six access facilities, distributed over Europe, will develop new technologies to better aid the research community in answering current day scientific questions, and will organize a wide range of meetings, courses and training events to disseminate their knowledge and expertise. Special emphasis will be placed on extending this knowledge to new member states of the European Union and other regions of Europe with less privileged availability of proteomics facilities.Access to the facilities will be advertised widely and will be open to all researchers in Europe, via an open, independently reviewed, online application system. Research proposals will be evaluated and, if selected, linked to an appropriate access facility.Many of the partners will be involved in research projects aiming at the development of new methods and tools to aid the access facilities and users. Results obtained will be communicated to both facility operators as well as user via pu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'EPIGENETIC MEMORY BY COMMUNICATION ACROSS CHROMOSOME SCALES' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The ability of cells to specialize and maintain their identity through multiple cell divisions is critical for development, tissue renewal and diseases avoidance. A key frontier is therefore to understand how genome organization and function is inherited to daughter cells. EPICHS targets a new paradigm for how epigenetic information is propagated, in which communication between the 2D epigenome and 3D genome organization maintains cellular identity. Inheritance of epigenetic states involves the copying of modifications on DNA and histones in cis on replicated DNA. However, this model lacks a spatial dimension, integrating that similar chromatin types separate spatially in the nucleus and replicates in a coordinated fashion. DNA replication severely disrupts the 2D epigenome, but it is unknown how replication locally impact on 3D organization and how spatial context shapes replication of the epigenome. EPICHS will interrogate chromosome replication across scales; we will develop new technology to address the interplay between 2D and 3D epigenome in epigenetic inheritance across replication. We will combine these technologies with machine learning, proteomics and fast-acting degrons to manipulate chromatin replication. Functionally, we will explore replication-induced 2D/3D dynamics and inheritance mechanisms in regulation of transcription and stem cell plasticity. Together, this will 1) provide the first knowledge of interdependencies and directionality in propagation of 2D and 3D organization, 2) reveal functions of DNA replication-induced plasticity in cell fate transitions, and 3) unveil spatio-temporal epigenetic mechanisms and their synergy with cis-based memory in maintaining cell identity.


**Keywords:** Chromatin replication, 3D genome organization, Cell fate de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'European Embryonal tumour Pipeline'.

assistant: **Concept**

Treatment of embryonal tumours (ET) is a challenge for the pediatric oncologist. Innovative translational research is required to exploit available genomic data and implement state-of-the-art technologies to overcome the deficits of current diagnostic and treatment strategies. We will set up a consortium of leading European institutions and SMEs with extensive clinical and technological expertise to establish a unique pipeline for the comprehensive development and validation of novel diagnostic tools in addition to efficient preclinical drug development for ET. Our holistic approach includes: 1) Validation of a chip-based diagnostic platform tailored specifically for ET including analysis of genes previously shown by the consortium to be affected in ET 2) Generation of ET-specific data on novel array-based platforms for the development of diagnostics at the microRNA and serum proteomics levels 3) Extension of an existing database designed to warehouse complete clinical and experimental data for neuroblastoma to include all ET entities 4) Implementation of a virtual ET-Biobank to improve sharing of patient samples 5) Functional characterisation of the most promising molecular targets previously identified by the partners as a foundation for entry into a drug development pipeline 6) Integration of existing disease-specific mouse models to evaluate new treatment modalities in vivo 7) Development and initial evaluation of an antibody affecting ET invasiveness 8) Application of novel bioinformatic solutions for the meta-analyses 9) Dissemination of the novel tools to researchers and clinical study centers in Europe Our coordinated effort can achieve the critical mass to facilitate the necessary integration of research capacities for translating ET genome data into significan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Estimation improvement based on improved requirements management'.

assistant: **Concept**

Gruppo PRO's core business is information systems automation in medium and large industrial companies. We customise and install products developed by ourselves and we provide assistance to the start up of the automated systems. Our process suffers from the low accuracy of the initial estimate of the customisation task. Due to the incompleteness of the initial requirements and to unmanaged changes a considerable percentage of unanticipated work creeps in during the very last project stages. Our goal is to increase the reliability of our cost and schedule estimates and to reduce the percentage of unanticipated work by improving our requirements management capabilities, including control over the requirements changes.THE EXPERIMENT The main actions in ESTREMA will focus on the following tasks:experimenting a methodical approach to the identification and representation of the user requirements. This method will involve the delivery of a feasibility study document serving as a basis for the initial cost and schedule estimatedefining and experimenting a change control procedure to manage requirements modifications and their impact on the initial estimatesexperimenting with a project performance assessment practice to establish requirements fulfilment and estimation accuracy; to this aim the collection of project performance data should allow the creation of a historical baseline to be used for improving successive estimates.In ESTREMA the experimentation will be carried out on a baseline project which consists of the adaptation and installation of our management information systems package PROJ in two companies belonging to sectors which are strategic for our business, and where the requirements are so different that our requirements and estimation process could be affected.E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantitative modeling of cargo-carrier biogenesis for model-based design of drug-delivery systems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Lipid-based drug delivery systems have shown great therapeutic potential, in particular for tumor targeting treatment. However, the production at relevant scales of such therapeutic agents remains a challenge due to the empirical nature of their development, and limited quantitative understanding of their biophysical properties. Remarkably, cells heavily utilize lipid carrier trafficking to encapsulate and transport with great efficiency various biological components to targeted sites in the intra- and extracellular environment. Inspired by the robustness of cellular trafficking processes, this proposal aims to elucidate the biophysical principles underlying the biogenesis of functional lipid carriers, and thereby direct the design and production of biomimetic transport carriers for drug delivery.Bringing together a complementary team of cell biologists, biophysicists, and mechanical engineers, we will develop a unifying modeling framework of vesicle biogenesis, in constant dialogue with experimental investigations of the mechanisms at play. The objectives of our integrated approach are two-fold: (i) elucidate the quantitative biophysical mechanisms of transport-carrier biogenesis mediated by coat proteins; and (ii) provide a toolbox for model-based design of liposome technologies for therapeutic drug delivery. All together, this project has potential impact in fundamental biology - by providing a systematic framework to formulate experimentally testable predictions and develop new ideas to control cellular functions in health and disease – as well as in biomedical engineering – by offering in silico solutions to design and test biomimetic cargo-carrier production processes for therapeutic applications.


**Keywords:** Cargo transporter, COPI, COPII, Endoplasmic Reticul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Pco2 reconstruction by chemical and isotope characterisation of fossil leaves'.

assistant: **Objectives**

Development of a new and reliable tool to reconstruct the co2 levels of past atmospheres based on 13c/12c ratios in fossil leaves. The method will be calibrated by comparison with the stomatal density of the leaves studies and the isotope measurements will be carried out on specific components to avoid any fossilisation bias.