RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Single Molecule Junctions With Non-Conventional Architectures, Crafted In Silico' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Unimolecular electronics is a cutting-edge field of materials research. It employs the ability of an organic molecule to conduct as a key component of miniature electronic devices and as a powerful tool for studying the intricate details of molecular structure. While state-of-the-art experimental techniques have been developed to manufacture and characterise the single molecule junctions (SMJs), empirical trial-and-error approach, predominant in this field so far, struggles to address some of the common shortcomings and deduce the design principles for future devices. In this proposal fundamental physical-organic chemistry concepts and high-level computational chemistry methods are employed to test the ability of several architectures to improve the performance and broaden the functionality of the SMJs. Specifically, cyclophanes and cage (polycyclic) alkanes are chosen due to their peculiar structures and intriguing charge transfer properties. Cyclophanes offer, in addition to conventional conduction pathways through the π-conjugated system, through-space transport via lateral π-coupling, while cage alkanes, e.g. adamantane, possess compact σ-electron density within a multitude of interfering conduction pathways. Moreover, inherent strain in such species can be utilised for direct coupling to the electrodes, while their hollow skeleton may be used as a molecular switch (via trapping). Potential of such systems in unimolecular electronics has already been illustrated in the recent literature, however a systematic ceteris paribus assessment is necessary to bridge their chemical-physical properties to SMJs efficiency. In this proposal both common and in-house computational chemistry tools will be used to identify molecular-level performance descriptors and deduce the relev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Complicity: A Crisis of Participation in Testimonies of Totalitarianism in Contemporary German-language Literatures'.

assistant: **Concept**

The aim of COMPLIT is to analyse the role of language in structures of complicity in humanitarian, political, ecological, moral and other wrongdoings that raise the question of what democratic participation means.The research project aims at interdisciplinary innovation, relating recent research in law and social sciences to testimonies of totalitarianism in contemporary German-language literatures by Herta Müller, Aglaja Veteranyi, and Elfriede Jelinek. The project expounds the comprehensive role of language in structures of participation and involvement, and highlights that the concern of testimonies of past totalitarianism is for the present: They outline modes of partaking in institutional violence that draws on heritage, culture, social, and gender distinctions still active in the globalized world of the present. The outlook onto the broader academic discussion and current societal problems strengthens the stance of humanities research by demonstrating its relevance to citizens at large.The scientific rationale of the project is a two-way knowledge transfer in the training-through-research of the applicant, who is an experienced researcher in the field of comparative literature with special regard to law and literature, and currently a research fellow at Yale University in the US. While transferring knowledge about an interdisciplinary, comparative approach to literature with a strong outlook onto societal challenges on highest international academic standards to the host institution, Universität Wien, the applicant will be reintegrated into the European research network.The COMPLIT project is of clear relevance to the Marie Skłodowska-Curie actions programme because it contributes to a better understanding of the current crisis in European integration and the back
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MITOCHONDRIAL RESPIRATORY CHAIN ASSEMBLY' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Oxidative phosphorylation (OXPHOS) is the metabolic process that provides most of the energy usable by the cells. OXPHOS couples two sets of reactions, respiration and ATP synthesis. Respiration consists in the sequential transfer of electrons carried out by the mitochondrial respiratory chain (MRC) complexes I (CI), II (CII), III (CIII), and IV (CIV). The proton gradient generated during respiration is used by the ATP synthase (CV). The components of the OXPHOS system, localized in the inner mitochondrial membrane, are large heteromeric enzymes whose subunits are encoded in two separated genomes, the nuclear and mitochondrial (mt) DNAs. The assembly of these subunits into the complete complexes is an intricate process in which many factors must interplay. In addition, it has been proved that CI, CIII and CIV interact with each other giving rise to supercomplexes (also called respirasomes). It has been determined that many mitochondrial disorders result in an altered assembly of one or several components of the MRC. However, many aspects of the mechanisms underlying the molecular defects in these disorders are still unknown. Therefore, it is necessary to investigate the assembly processes and the involved factors, in order to get a deeper understanding on OXPHOS biogenesis that will shed light on the pathogenetic mechanisms underlying the mitochondrial disorders caused by defective complex assembly. The objectives of the study will be: 1) to determine the entry point of the mtDNA-encoded CI subunits in the assembly process of this complex, which remains to be established; 2) to determine the order of events and the involved factors in the assembly process of human and mouse CIII which has not been studied yet in mammalian systems and 3) to study the factors and processe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Immune-Image: Specific Imaging of Immune Cell Dynamics Using Novel Tracer Strategies' (Immune-Image), addressing dissemination and exploitation.

assistant: **Impact**

Immunotherapies have emerged as effective treatments for immune system-related diseases, such as cancer and inflammatory diseases. Although immunotherapeutics are effective not all patients benefit and side effects vary greatly. Thus, there is an unmet need for a personalized approach. Blood and tissue biomarkers have played only a modest role up until now in assessing immune status in vivo and we believe that non-invasive whole body imaging will make a significant contribution in the future. Although the field of imaging (PET, MRI, Optical Imaging) is flourishing, its application to patient immune status measurement and monitoring has barely been explored. Within Immune-Image we aim to develop new immunotracers for imaging specific immune cell subsets, develop quantitative imaging workflows, validate the immunotracers pre-clinically in relevant disease models, produce the tracers in a Good Manufacturing Practice (GMP)-compliant way, and conduct smart clinical trials, including with novel tracers.To this end, insights will be gained into the optimal use of drugs and a more efficient development of immunotherapeutics. Moreover, the success rate of immunotherapy development will be enhanced since our molecular imaging platform will provide novel insights into patient immune status, which will support drug development and treatment decisions.To achieve our goals, we have assembled an experienced international multi-disciplinary consortium composed of chemists, biologists, immunologists, physicists, pharmacists, information technologists, and medical specialists with diverse and essential backgrounds who will join forces to design, synthesise, evaluate and validate immunotracers and create sustainable molecular imaging techniques that can be broadly applied in the assessmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'PREFIGURING DEMOCRATIC FUTURES. CULTURAL AND THEORETICAL RESPONSES TO THE CRISIS OF POLITICAL IMAGINATION' (PREDEF), addressing dissemination and exploitation.

assistant: **Impact**

Democracy is in a crisis of global scale. This crisis has variously been attributed to a loss of belief in political representation, the rising of technocratic post-democracy, or an authoritarian and populist turn. However, a narrow focus on the political system is inadequate. PREDEF starts from the assumption that the crisis of democracy is also a crisis of political imagination. As the infamous TINA-principle (There is no Alternative) illustrates, it has become increasingly difficult to imagine genuine democratic alternatives to the status quo. PREDEF sets out to explore potentials for deepening and pluralizing democracy beyond the sphere of politics narrowly defined as the body of existing political institutions. The project will turn to the fields of culture, art and intellectual history, for these fields hold hitherto untapped potentials for extending our democratic imaginary and disclosing political alternatives. Located at the intersection between cultural research and democratic theory, PREDEF meets this challenge empirically and theoretically. Empirically, artistic and cultural counter-practices are investigated that champion democratization in the time-based arts (through theatrical occupations), international relations (through counter-summits) and law (through mock tribunals). Theoretically, the project seeks to widen our democratic imaginary by searching the history of ideas for forgotten institutions that hold untapped democratic potentials, and by elaborating a democratic theory of counter-institutions. The main objectives are: i.regaining a sense of possibility in a time of vanishing democratic alternatives,ii.exploring the democratizing potential of cultural and artistic practices and institutions;iii.learning from alternative configurations of the past
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Game: Counter-mapping informal refugee mobilities along the Balkan Route' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The Balkan Route is the most important overland informal migration corridor in Europe, taken by thousands of refugees every year. Linking Greece to Western Europe across Bulgaria, Romania, Albania, North Macedonia, Kosovo, Montenegro, Serbia, Bosnia-Herzegovina, Slovenia, and Croatia, the Route is a complex geography of formal and informal, visible and ‘invisible’ sites; an assemblage of diverse actors, camps, borders, violence, solidarity, and a multiplicity of micro-routes, constantly adapting and shifting.    Across and between these interconnected spatialities, refugees forge their trajectories towards Europe through ‘The Game,’ the term they use to refer to clandestine journeys. Along the Route, an archipelago of makeshift camps has emerged, hosting thousands of refugees as they repeatedly attempt to enter Europe. Key in producing and sustaining The Game, these sites serve as temporary shelters, nodes of services and information, where refugees meet smugglers, wait, and plan the next move.    To understand how informal migration corridors work TheGAME aims to: (1) theorize makeshift camps as distinct spatialities with a unique social and political life; (2) investigate the Route’s archipelago of makeshift camp as an inter-connected, corridor-forming counter-geography; (3) produce an archive-in-progress documenting refugee experiences of a corridor endlessly re-invented across space and time; (4) employ counter-mapping as a methodology capable of critically understanding how the Balkan Route functions and propose a novel and replicable approach to studying informal migration corridors globally.     TheGAME is the first transnational, multi-sited, multi-temporal, extensive ethnographic research on an entire informal migration corridor, a ground-breaking project with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Imaging liver immunopathology by intravital microscopy (IVM): a new approach to study the pathogenesis of hepatitis B virus (HBV) infection' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Overall objective and Specific Aims. The overall objective of this proposal is to elucidate the pathogenesis ofHBV infection with the ultimate hope that this knowledge will lead to the development of new therapeuticstrategies to terminate persistent infection and its attendant costs and complications. Our approach is to dissectpoorly understood cellular and molecular pathways responsible for both liver disease and viral clearance takingadvantage of technological advances in the field of live imaging and unique mouse models of HBV infection.Three specific aims will be pursued:1. Visualize and characterize where and how naïve and effector CTL of different specificities adhere tovessels and recognize/kill HBV-expressing hepatocytes within the “normal”, fibrotic/cirrhotic orcancerous liver.2. Characterize the role of platelets in HBV pathogenesis.3. Characterize the role of Kupffer cells in HBV pathogenesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Towards DNA chip technology as a standard analytical tool for the identification of marine organisms in biodiversity and ecosystem science', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Sustainable development is a fundamental goal of the European Union and loss of biodiversity is emphasised as one of the main threats to it. However, biodiversity and ecosystems of European Seas are under human impact, such as pollution, eutrophication, and overfishing. Therefore it is necessary to monitor changes in biodiversity and ecosystem functioning. The aim of the project is the development of DNA chips for the identification of marine organisms in European Seas as a cost effective, reliable and efficient technology in biodiversity and ecosystem science. Many marine organisms, such as eggs and larvae of fishes, plankton, and benthic invertebrates, are difficult to identify by morphological characters. The classical methods are extremely time consuming and require a high degree of taxonomie expertise. Consequently, the basic step of identifying such organisms is a major bottleneck in biodiversity and ecosystem science. Therefore, the project seeks to demonstrate that DNA chips can be a new powerful and innovative tool for the identification of marine organisms. Three DNA chips for the identification of fishes, phytoplankton, and invertebrates of European Seas will be developed. These chips will facilitate research on dispersal of ichthyoplankton, monitoring of phytoplankton, and identification of bioindicators as well as prey in gut contents analysis. To achieve this goal a combined biological and technical approach has been initiated: The biological material will be sampled by marine biologists. The next step is the sequencing of suitable molecular markers for probe design. The technical part consists mainly in constructing gene probe libraries and determining their specificity. This will be done by biotech research centres in connection with SMEs engaged in bioi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Spatial processing under attentional load: from clinical to fMRI evidence', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Everyday life requires to continuously process the surrounding space to extract behaviourally-relevant information. When attention is loaded, however, this processing might become difficult. This happens, for instance, when space has to be attended while additional stimuli have to be processed in parallel (e.g., talking while driving). In the present project the attentional system will be loaded through visual or auditory dual-tasking to investigate the core cognitive and neural mechanisms subtending normal and pathological (stroke patients) spatial processing.Dual-tasking will be adopted in patients to characterize those subtle post-stroke attentional deficits in the processing of one side of space which often go undetected by traditional paper-and-pencil tests. Patients' behavioural deficits will be matched with specific brain damaged areas by symptom-lesion mapping analyses.Healthy participants will be studied through a brain imaging technique called functional Magnetic Resonance Imaging (fMRI). fMRI will detect the functional changes in brain activation under different attentional load conditions, allowing to isolate task-dependent and load-dependent brain areas.By binding together clinical and neuroimaging techniques, this project aims to strongly contribute to understand the cognitive neuroscience of  spatial processing and its normal and pathological limits under dual-tasking. Both the fMRI and the clinical workpackages are expected to provide converging evidence in determining the contribution of specific brain areas while processing space under different levels and types of attentional load.Through this project the applicant will gain a strong expertise in the use of fMRI by joining an excellent cognitive neuroscience lab, embedded within a multidisciplinary co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Centre for Design and Structure in Biology (CDSB)' (CDSB) under Fourth Framework.

assistant: **Objectives**

Principal characteristics of the facility and of the support offered to users: This proposal is aimed at establishing a joint large-scale facility named Centre for Design and Structure in Biology (CDSB) based in Naples (Italy) at the Biocrystallography Research Centre, and in Jena (Germany) at the Institute of Molecular Biotechnology. The two institutes forming the Joint Centre are willing to make their unique combination of high-end instruments for structural biology available to researchers from the European Union. The application presented here describes the access offered by the Jena branch of the Joint Centre, while the application of the Naples branch is submitted as part of the same package. Modern molecular biology and biotechnology rely on a detailed knowledge of the architecture of biological macromolecules, in order to understand their function, to change their properties by engineering, or to design other molecules (e.g. drugs) interacting with them. Today, a whole range of techniques are available to elucidate the three-dimensional structures of proteins and nucleic acids, in particular X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, electron microscopy, and molecular modeling. With the molecular systems being studied getting ever more complex, a combination of techniques for structure determination is becoming necessary in an increasing number of cases. However, all three techniques are rarely available in one institution, and if they are, they are usually not equipped with state-of-the-art instruments. This is different for the Joint Jena-Naples Centre for Design and Structure in Biology (CDSB) proposed here. The Joint Centre could offer access to as many as 4 NMR spectrometers in the 400 - 750 MHz range, three rotating anode X-ray g