RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Chemistry of the upper troposphere: laboratory studies of heterogeneous processes on ice'.

assistant: **Objectives**

Problems to be solvedOzone in the upper troposphere is an important greenhouse gas that is formed mainly by photolytic degradation of NOx. Between 40 and 50° N, some 40 % of upper tropospheric NOx over Europe is a result of transport from the polluted boundary layer, with aircraft emissions contributing a further 30 %. This program of research will allow us to estimate the influence of ubiquitous cirrus ice particles on upper-tropospheric oxidant cycles, and ozone concentrations. The resulting advancement in understanding of the photochemistry of this sensitive part of the atmosphere will enable improved assessment and control of ground and aircraft emissions that impact on upper-tropospheric ozone concentrations and thus the atmospheric radiation budget. The objectives of this proposal are consistent with contents of the Kyoto protocol and the Long-Range Transboundary Air Pollution Convention, which aim to better control the chemical species that have an impact on air quality and climate. It also has direct bearing on the policies of the Framework Convention on Climate Change (IPCC) and the International Civil Aviation Organisation (ICAO) which is responsible for the implementation of standards to regulate international air traffic.Scientific Objectives and approachThis is a proposal of laboratory based research designed to enhance our understanding of the factors that influence the seasonal and latitudinal variability of ozone in the upper troposphere, and in particular the extent to which the natural chemistry of the upper troposphere is being impacted by growing atmospheric pollution. This proposal focuses on the role of cirrus ice in modifying the chemical composition of the upper troposphere, and its response to pollutant inputs. The chosen approach is to combine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Intervention strategies against malaria' to be submitted under Seventh Framework.

assistant: **Abstract**

Malaria exacts a devastating social and economic cost across  the globe. Europe is at the forefront of the battle against this disease. It contains many of the leading malaria research groups, most of which are members of at least one of two consortia; BioMalPar, a Network of Excellence focused on basic research  into the biology and pathology of malaria; and AntiMal, an integrated project aiming to develop a portfolio of new antimalarial drugs, urgently needed to meet the problems of drug-resistant malaria. To sustain the competitiveness of European malaria research into the future, there is a need to integrate these initiatives by the establishment of a broad-based training programme that emphasises the path from fundamental research to translation into disease control strategies.  To address this need, it is proposed to establish an international training programme called InterMalTraining which will train a cohort of early stage researchers (ESR) to PhD level by means of collaborative malaria research projects. Each project will be jointly supervised by two principal investigators from separate partner institutions and usually different countries, affording a multicultural and multidisciplinary element to the training. Through this and additional broad-based, intensive training provided by experts from both the malaria research community and the industrial sector, it is intended to create a new generation of mobile, highly skilled young scientists who will be well acquainted with each other and with the leading malaria groups in Europe and beyond, enhancing their prospects for a career in their chosen area and suiting them to be future leaders in research institutions and industry. The cross-disciplinary nature of the training will have the breadth to ensure that it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ion Transport at atomic level' (ITrans).

assistant: **Concept**

Cell membranes provide compartmentalization and allow cells to keep their physical-chemistry balance. Ion transport across cell membranes is vital for life, establishing and maintaining a difference of electrochemical potential.  From the biosynthesis of energy to the transport of solutes, ion transport is central to the energy transduction process.One of key players in the energy transduction process is the respiratory Complex I (NADH:ubiquinone oxidoreductase.  This membrane domain of Complex I has three homologous antiporter subunits where the proton channels are proposed to be located. Recently, new results indicate that Complex I from different bacteria are also able to transport H+ and Na+ in opposite directions. This data prompt the debate on the atomic mechanism behind such antiporter subunits and how such process can be regulated.The aim of this project is to provide the missing piece of behind the antiporter subunits puzzling mechanism. To approach such task two objectives have been draw: a) decipher the mechanism of ion transport of the antiporter subunits of Complex I at atomic level, b) unravel the how the regulation and control of ion transport is performed in Complex I antiporter subunitsTo pursue these objectives a novel sample preparation methodology to perform NMR spectroscopy of membrane proteins will be setup. This experimental setup will combine recent advances in cell-free expression system of membrane proteins with nanodisc technology, providing the antiporter subunits a native membrane like environment to perform solution NMR.To follow ion transport, the antiporter subunits will be selectively isotopic labelled and the NMR spectra will be monitored for changes upon ion transport. These changes will provide a map of the ion channel in the antiport
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The obesity-induced macrophage: a new player in atherosclerosis development' (MACOBESITY) targeting Seventh Framework.

assistant: **Abstract**

Obesity is an independent risk factor for atherosclerosis but the exact mechanistic link between these conditions is unknown. Parallel to atherogenesis, obesity induces the recruitment of pro-inflammatory macrophages from bone marrow to adipose tissue (AT).We hypothesize that obesity-induced macrophages, through interactions with adipose tissue-derived free fatty acids, are important players in atherosclerosis development and thereby represent the key link between these conditions.First, we will investigate the effects of obese AT on the phenotype and function of adipose tissue macrophages (ATMs) and the consequences for atherogenesis. Since it is known that obesity leads to recruitment of CD11c-positive, dendritic cell-like ATMs, the effects of local AT-derived free fatty acids (FFAs) on ATM phenotype and their antigen-presenting capacity will be assessed in vitro and in vivo using mouse models. Additionally, we will isolate CD11c-positive and CD11c-negative (resident) ATMs from obese AT and compare them by genome-wide expression analysis and functional studies. Moreover, the effects of ATMs on adaptive immune responses and atherosclerosis will be assessed by transplantation of obese AT to atherosclerosis-prone low-density lipoprotein receptor deficient (ldlr-/-) mice. Second, we will investigate the effects of FFAs on the differentiation of macrophages from bone marrow cells and the consequences for atherosclerosis development. Hereto, we will determine how FFAs affect differentiation of bone marrow cells into macrophages by performing functional characterization. The obtained results will be evaluated in vivo by adoptive transfer of bone marrow-derived macrophages, treated ex vivo with FFAs during their differentiation, to ldlr-/- mice. Atherosclerosis development an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CircHtt in brain development and Huntington`s Disease: elucidating  in vivo brain functions of a novel circular RNA molecule stemming from the Htt locus' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

I am a neuroscientist specialized on brain development and genetic brain disorders. During my PhD with Dr. Gaia Novarino (IST Austria) I developed a strong expertise in using in vivo mouse models and a large number of different techniques to investigate the underlying cause of intellectual disability and autism. My work helped to better understand the pathophysiologic mechanisms driving these complex neurodevelopmental conditions, as well as the process of brain development more in general. Now, I aim to expand my research profile to neurodegeneration and the non-coding genome, specifically circular RNAs (circRNA). As a postdoctoral researcher in the lab of Dr. Biagioli at Dep. CIBIO (UniTN) I seek to combine my strong background in functional in vivo studies with her outstanding expertise in Huntington`s Disease (HD) research and epigenetics to elucidate a novel regulatory pathway in HD. In this proposal, I designed a dedicated research and training plan that will significantly expand my scientific portfolio and uncover the in vivo functional role(s) of circHTT, a newly discovered circRNA molecule -discovered and initially characterized by Dr. Biagioli’s lab - stemming from the HD locus. We will study its mouse orthologue, circHtt, focusing on expression dynamics and pattern during development and aging and visualize its cellular and subcellular localization in the brain. We will analyse its relevance for HD pathology by using HD mouse models and uncover its molecular brain function(s) by exploiting the innovative and highly specific CRISPR-Cas13 knock-down machinery in vivo. The results of this project will highlight a novel regulatory network in HD pathophysiology in which circHTT may act as modifier of/or novel biomarker for HD progression, or represent a novel mole
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Solar Prominences: Stability, Magnetohydrodynamics, and Seismology""' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The solar corona is a natural laboratory to study the behavior and properties of plasmas under conditions that cannot be realized in a laboratory on Earth. Understanding the plasma behaviour in the solar atmosphere is a necessary prerequisite for our understanding of plasma behaviour in the atmospheres of other stars and space weather. The focus in this proposal is on Solar Prominences, spectacular large-scale magnetic structures of the solar corona. Very recent observations have reported on exciting prominence dynamics with unprecedented temporal and spatial resolution as, e.g., oscillations, waves, flows, and instabilities in the fine structure of prominences (threads). Thread oscillations have been interpreted as magnetohydrodynamic (MHD) waves. Flows may drive Kelvin-Helmholtz instabilities (KHI) and resonant flow instabilities (RFI), while the fine structure may be thermally unstable. Despite the timeliness and relevance of the observations, these phenomena are not well-understood. The present research project aims to investigate oscillatory dynamics and stability of prominence threads from a theoretical point of view. This proposal is organized into two sub-projects. The main goals of sub-project A will be to study MHD wave properties in prominence threads. The combination of our theoretical results with the observations will allow us to apply the technique of MHD seismology to indirectly infer the values of relevant physical parameters of the prominence plasma. In sub-project B, we will focus on prominence plasma instabilities. We will study thermal instability of threads and both KHI and RFI driven by shear flows. Throughout this investigation, we will make use of analytical methods in combination with advanced numerical simulations. The research results of this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Photonic Applications of Nanoparticle Assemblies and Systems' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The proposal covers  the  planned actions of  a  consortium consisting of  five  members. These are  all  research organisations, three of which are EU -based with one other being based in Russia and the final organisation being based in Japan. The  consortium  intends  to establish a research programme which  is aimed at the production of  advanced structures that include colloidal assemblies, nanoparticles, oxides and metals  in order to gain a fundamental understanding of their properties with the aim of using them for manipulation of light on the nanoscale. The planned work is described in detail in the form of three work packages (WP). The first addresses key roadblocks in the exploitation of nanophotonic materials and is entitled 'From ‘imperfect’ colloidal crystals to functional engineered nanophotonic architectures'.    The second is entitled 'Metallodielectric colloidal crystal platform for plasmonic circuits and optical transformations ' and addressing key issues associated with novel device operation. The third is devoted to the idea of organising two  Summer  Schools, one in Europe and one in Japan, thus disseminating the most up-to-date knowledge available. The School(s) intend to cover the area  of  the  interaction  between light and  a range of optically-active materials  under differing conditions, while they will also focus on possible applications of these materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Science for the People' to be submitted under Sixth Framework.

assistant: **Abstract**

The main idea behind organizing the project is to raise public awareness of the role played by researches in society, to demonstrate that practical applications of scientific achievements profoundly affect our day-to-day existence, and to encourage young p eople to pursue scientific careers. In frame of the IX Science Festival - Warsaw - 2005 (16-25 September) five additional chain-like events will be organized. They include the following topics: 1. Educational and reserach possibilities for undergraduate, graduate, and postgraduate students in European Research Area. Polish society, a new member of the EU community, needs more information about new and attractive opportunities in the field of education and research. 2. Science (physics) is not difficult. Lack of understanding physics is a significant barrier to learning of natural science. It may further result in discouraging young people from studying natural science. 3. See how it works: science in everyday life. General public is not aware how nume rous basic studies are hidden behind new technologies. 4. From disease to therapy. Rational drug design is a perfect example of how combined methods of biochemistry, molecular biology, physics, bioinformatics, and computer technology contribute to invent ing new drugs. 5. Decreasing the level of aggression. Increasing level of aggression observed within societies, as well as between different countries has become one of the most pressing problems for mankind. We should better recognize the true causes an d mechanism behind this worrying phenomenon. Forms: debates, workshops, demonstrations, interactive presentations performed by academics and scientists. All events will be open both to general public and to organized school classes. Entry: free of char ge.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Novel Experimental and Modelling approach for Optimisation of Light alloys' to be submitted under Seventh Framework.

assistant: **Abstract**

We propose a novel multi-disciplinary approach for the optimisation of light alloys for structural applications in the objective of weight savings and reduction of greenhouse gas emissions for transportation applications. This approach will combine advanced experimental investigations in the fields of physical metallurgy and materials electrochemistry and the development of a mesoscopic modelling tool, and will be applied to precipitation-hardening Aluminium alloys. The development of nano-scale, multi-phase precipitate microstructures will be quantitatively characterised by advanced experimental techniques, including time-resolved synchrotron X-ray scattering, nuclear magnetic resonance, atom probe tomography and electron microscopy. It will be modelled by a physically-based approach, going well beyond the state-of-the-art by addressing the complexity of the sequence of metastable phases and of the competitive formation of multiple phases in multi-constituent alloys. The project will be carried out first on a model Al-Cu-Sn alloy and then applied on industrial alloys. The project will be carried out in two institutions that are world leading in their respective fields of physical metallurgy and design of light alloys. It will involve active training of the main researcher on multi-disciplinary experimental research tools, on modelling of phase transformations in metals, and on research administration. The project will improve the excellence of the return host (Grenoble Institute of Technology) in the field of light alloy research, improve its international links and recognition, and will impact Europe’s capabilities in the design and production of high performance light alloys. The project will improve the prospects of the main researcher to reach a prominent academic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Privacy Preserving Perimeter Protection Project' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The goal of the P5 project is an intelligent perimeter proactive surveillance system that works robustly under a wide range of weather and lighting conditions and that has strong privacy preserving features. The system will monitor the region outside the security area of critical buildings and infrastructure, and give early warning if terrestrial or airborne threats are detected. The system will support, rather than replace, a human operator. A low false alarm rate due to animals or other innocuous events, combined with high threat detection sensitivity and privacy standards, are central ambitions of the project. To achieve these goals, a multispectral sensor suite comprising both passive and active sensors is envisaged, i.e., a system based on radar, visual and thermal sensors. The sensor suite will be complemented with advanced algorithms for information fusion, object detection and classification, privacy preservation, and high level modelling of intent and behaviour analysis.  The P5 project is strongly user-driven and demonstration of the developed surveillance system will be conducted at two different critical infrastructure sites.  Finally, the P5 project will make contributions to evolving standards in detection systems.