RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Inter-hemispheric Coupling of Abrupt Climate Change' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The primary goal of the proposal is to advance understanding of the governing mechanisms and inter-hemispheric coupling involved in abrupt climate change. Abrupt climate change involves complex non-linear interactions between all components of the global climate system. Such changes have been caused by natural factors in the past but could in the future be triggered by anthropogenic forcing. The proposal will exploit past abrupt change in order to inform on future risks. We propose to synchronise the Law Dome (Antarctica) ice core record to the state-of-the-art Greenland ice core chronology (GICC05) during the most prominent abrupt climate change within the current interglacial period (the ‘8.2 ka event’) and also during the sequence of abrupt climate changes which preceded the last deglaciation. The core offers unrivalled temporal resolution and dating precision for a southern hemisphere record. Rapid global variations in methane gas concentration will be used as dating ties for these synchronisations. The project will lever from the accurately dated Law Dome record to obtain a broad inter-hemispheric view of abrupt climate change. The palaeoclimate data will be interpreted alongside transient climate model simulations of abrupt climate change and integrated with those simulations. The applicant has strong experience in interpretation of southern hemisphere records and in the synthesis of palaeoclimate data. The modeling component of the project and hosting at the leading European centre for the study of Greenland records of abrupt climate change will broaden his expertise and cement his international research career. The new skills brought to Europe and multidisciplinary approach of the project offer strong potential to catalyse lasting collaborations and advance our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A multi-cancer screening platform for fast and accurate early stage cancer detection from urine samples' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Globally, more than 18 million people are diagnosed with cancer each year and this number is set to exceed 22 million by 2030. According to the World Health Organization (WHO), about 50% of cancer deaths could be avoided by enabling early cancer detection. Unfortunately, the market is still lacking a general test, suitable for the whole population, for detecting any type of cancer before the presentation of symptoms. Current gold standard procedures are highly invasive and risky, specific for one cancer type, and highly expensive. These factors limit their adoption to suspected cancer cases – i.e., after the presentation of symptoms, delaying cancer diagnosis and contributing to the huge economic burden on healthcare systems. To overcome this problem, MDB DIAGNOSIS GROUP LTD (‘MDBD’) has developed Cancersensing, a revolutionary accurate and rapid screening platform for early diagnosis of multiple cancers from a single urine sample. The platform includes a highly specific and sensitive test that measures cancer-related biomarkers present in the urine, and a diagnostic software suite powered by proprietary machine learning algorithms and reference databases. Cancersensing makes cancer detection in its early stage available to all, maximizing survival rates and quality of life for patients, and reducing treatment costs and the cancer-related economic and societal burden.During the feasibility assessment, MDBD will establish a go-to-market strategy and a supply chain, and define further development plan. During the second phase of innovation project, MDBD will optimize the Cancersensing screening platform, and perform clinical validation activities with hospital partners in the EU to obtain regulatory approval for commercialization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Getting ready for multi-vendor and multi-terminal DC technology' to be submitted under Horizon Europe.

assistant: **Abstract**

Power Electronics is enabling radical transformation in the power grid and, in particular, it is opening the opportunity for a massive application of DC technology. DC technology will increase the overall flexibility and efficiency of the infrastructure. Nevertheless, this innovation comes with challenges in terms of interoperability when we consider networks with multi-vendors. The concrete case of off-shore wind farms is then the starting point for the transformation. READY4DC will create the right conditions to establish a community of experts that will discuss all the implications of the process both from a technical and a legal perspective. Thanks to the work of a set of working groups with open participation, position papers will be produced to create the proper conditions for consensus paving the way towards changes in the regulation and in the legal framework. The results of this work will impact not only the off-shore use cases but, in principle, all the application of power electronics driven grids and at every voltage level, determining a very important step towards a futuristic infrastructure in which DC will play a central role at every level.


**Keywords:** Power Electronics, HVDC, Interoperability, off-shore grids
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Dependence Of NUcleosome Transactions on Sequence'.

assistant: **Objectives**

Eukaryotic genomes are packaged into chromatin, which restricts access to the DNA. Key genomic processes therefore involve the rearrangement of chromatin by ATP-dependent chromatin remodelling enzymes (remodellers), which actively place and reorganise nucleosomes. The precise positioning of nucleosomes plays a crucial role in regulating transcription, replication, and DNA repair. DNA sequence impacts this nucleosome architecture by affecting the activity of remodellers. However, what mechanisms underlie this critical sequence dependence in remodelling remains unknown. Here, we propose to address this longstanding question based on the following rationale: the nucleosome represents a highly constrained substrate with many histone-DNA interactions. Remodeller action therefore involves multiple sequential catalytic cycles and a series of transient structural intermediates of the nucleosome. We hypothesise that the nature and stability of these intermediates determine the effects of DNA sequence on remodelling. Probing this hypothesis requires the direct observation of transient remodelling intermediates as a function of sequence at the genome scale, which cannot be achieved with currently existing methods. We aim to address this major challenge by developing a novel high-throughput platform that combines, for the first time, single-molecule measurements of complex dynamics with next-generation sequencing. This platform will enable the comprehensive profiling of sequence-dependent processes at the single-molecule level. We will leverage the platform in combination with molecular simulations and in vivo experiments to gain groundbreaking insights into the mechanisms of sequence-dependent remodelling and its role in the establishment of chromatin architecture. Ultimately, we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Modular Approach to Hybrid Electric Propulsion Architecture' under Horizon 2020.

assistant: **Concept**

The overall objective of MAHEPA is to bridge the gap between the research and product stage of a low emission propulsion technology to meet the environmental goals for aviation towards the year 2050. Two variants of a low emission, high efficiency, serial-hybrid-electric propulsion architecture will be advanced to TRL 6: the first uses a hydrocarbon fuelled internal combustion engine and an electric generator as primary power source, while in the second a hydrogen fuel cell is used to produce power showcasing the flexibility of the architecture. Common to both variants is the power control module, used to implement advanced power management methods to optimize mission, range and emissions of hybrid electric aircraft, and the new power electronic devices namely a highly efficient, airborne qualified electric propulsion motor and next-generation inverter technology. The modular approach is further demonstrated by integration and flight testing of each variant on a different small aircraft to showcase flexibility and scalability of the powertrain. A visionary implementation study towards commercial/transport category aircraft rounds up the project. The core value of MAHEPA is to build-up technological know-how and use flight test data to validate performance, efficiency and emission reduction capabilities of above technologies. This will allow to make conclusions about the suitability of these solutions towards megawatt-scale hydrocarbon driven hybrids and zero-emission hydrogen-powered solutions. For small aircraft this propulsion system development can be the door opener for a commercialized, new, low emission, highly efficient airplane category.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Energy Transfer Catalysis: A Highway to Molecular Complexity' in the context of a Horizon Europe call.

assistant: **Objectives**

The development of novel synthetic methodologies is one of the most essential chemical research areas since the access to organic molecules is the foundation for many applied sciences (e.g. medicinal chemistry, materials science). In recent years, the construction of increasingly complex molecular scaffolds has gained significance, with a particular need for conformationally restricted, three-dimensional architectures. However, the synthesis of such molecular frameworks remains exceptionally challenging, limiting their application in other research branches. Consequently, revealing novel strategies to convert simple feedstock chemicals into complex building blocks has a beneficial impact on society as a whole. In HighEnT we will disclose ground-breaking methodologies augmenting the synthetic toolbox of organic chemists focusing on expanding the chemical space to discover pharmacologically relevant structural motifs. The key to success is the creative and innovative utilisation of the unique triplet excited state reactivity enabled by visible light-mediated EnT catalysis, providing a platform for unconventional retrosynthetic disconnections. Based on our broad expertise in this field, we will investigate diverse areas of EnT catalysis including non-classical and dearomative cycloadditions as well as σ-bond cleavage processes. In each domain longstanding challenges will be solved with respect to product motifs, chemical space expansion, and mechanistic understanding. Furthermore, we envision the merger of N-heterocyclic carbene (NHC) organocatalysis with EnT catalysis, opening otherwise locked reaction pathways. Finally, to guide our product- and mechanism-oriented reaction discovery, we will develop and apply a novel prediction platform based on the interconnection of qu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Exploring the lower concentration limits of micropollutant biodegradation in oligotrophic microbiota' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Organic micropollutants (OMPs) such as pesticides, pharmaceuticals, and synthetic hormones, are emerging contaminants in environmental freshwaters including drinking water resources. OMPs occur at extremely low concentrations (μg – ng/L range), but they may have adverse ecotoxicological and/or human health effects. The EU therefore strives to minimize OMP pollution in freshwaters and introduced stringent concentration limits in drinking water (100 ng/L or lower). Many bacterial strains have been reported that use OMPs for growth and hence mineralize them. Therefore, biodegradation is considering an important mechanism for OMP removal in freshwater systems. However, recent research has shown that the intrinsic trace concentrations of OMPs compose a major bottle neck of OMP biodegradation, since they poorly sustain the energetics of degraders’ cells and leading to physiological adaptions that eventually affect microbial degradation activity. OMP biodegradation has been exclusively studied using copiotrophic strains that thrive well at high pollutant concentrations while the oligotrophic degraders adapted to low substrate concentrations have been largely neglected. The Micropol_Oligo project aims to comparatively study the capacities of oligotrophic and copiotrophic bacteria to degrade OMPs at relevant trace concentrations and to explore the mechanisms underlying the lower concentration limits of OMP biodegradation. To this end, we will examine whether differences in lower concentration limits exist between copiotrophic and oligotrophic 4-chloro-2-methylphenoxyacetic acid (MCPA) catabolic bacterial strains, and investigate the roles of mass transfer limitation and the molecular mechanisms of physiological adaptations in biodegradation of trace MCPA. The outcome of the proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Architectural Culture of the Early Modern Eastern Adriatic' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

During the 15th century, the political process of reducing the Eastern Adriatic, here considered as encompassing what is now littoral of Slovenia, Croatia and Montenegro, to a thin strip of border territories substantially separated from the continental massive to which they belong, reached its conclusion. The insularity of its large natural archipelago, i.e. almost exclusive dependence on the maritime communications, became characteristic even of mainland coastal towns, with lasting consequences. The project explores the impact of this change in the area between 15th and 18th c., focusing on architecture as the most evident materialization of a culture and its transformations. The goal is to examine the architectural culture in question in terms of both consumption and production. Factors such as political and economic consolidation of Venetian and Dubrovnik Republics as well as Habsburg Empire in the area, war and commerce with the Ottomans, but also the quick spread of revival of antiquity and the Catholic Revival, all fuelled the need for architectural creation with certain functional and symbolic characteristics, setting the cultural standards. On the other hand, the economics of production of architecture consisted of interrelated systems of the provision of materials (esp. Istrian stone) and organisation of construction sites, which, given the ease of the sea transport, resulted in an active market for architectural goods. This approach will provide an original contribution to the understanding of cultural practices that not only produced specific buildings, the most significant among which are now listed as World Heritage sites but also put into circulation ancient and modern models, techniques and materials for a European-wide audience. Moreover, it will invest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advanced semisolid forming of complex structural somponents' to be submitted under Fourth Framework.

assistant: **Abstract**

The object of this project is the production of safety important structural component by aluminium semisolid forming (Tixoforming). Semisolid forming is a relatively new process of metal shaping in the semisolid state which incorporates elements of both casting and forging. This leads to technical and economic benefits:  high dimensional accuracy which enables the process to be suitable for the production of near net shape parts (important reduction of machining operations)  energy saving because the process requires only 50 60% of the energy necessary for high pressure die casting  high mechanical properties (similar to the forging ones)  better working conditions  longer die life On such a base, the industrial goals of the project could be summarised as follows: 1. overcoming the present limits of the thixoforming process in order to produce net shape important (weight>1kg) and complex structural components 2. definition of a methodology for die design and process parameters optimisation which permits to reduce more than 30% the time necessary to obtain the first sound part. The main expected deliverables of the project are the following:  a methodology for component/die design and process parameters optimisation based on experimental data and process numerical simulation;  two different car component for structural, safety application;  one aeronautical components for structural application;  one motorcycle component for structural application;  economical benefits evaluation. The planned activities are structured for complementary competencies (automotive, motorcycle, aeronautical, SME industries) through quality methodologies in concurrent engineering, design for process capabilities and simultaneous cost analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mechanisms of Emotion Control: Identifying Neuro-Cognitive Abnormalities Predisposing to Hypertension' (COEM).

assistant: **Concept**

Essential hypertension (EH) is the most important risk factor for cardio- and cerebro-vascular diseases, the most common cause of premature death in industrialized countries. This proposal addresses the hypothesis that neuro-cognitive abnormalities serve as a key risk factors in the development of EH. It is well established that patients with EH, and healthy individuals genetically at risk to develop hypertension later in life, show cognitive abnormalities. They further exhibit magnified neural and vascular reactions to aversive stimuli. Taken together, this evidence suggests that abnormal functioning of cognitive control mechanisms may underlie the enhanced reactions to aversive events, which may result in persistent hypertension.The current proposal is based on two phases: first, a series of behavioural experiments will examine attention-emotion interactions in healthy participants. These experiments will examine which stages in emotional processing may be modulated by attention, as well as possible interaction between expectancy and attention biases. At a second step, research will focus on identifying neuro-cognitive abnormalities in individuals at high-risk to develop EH. To this aim, the tasks established in the first phase will be employed in healthy individuals at high- or low-risk to develop EH. This phase will be based on simultaneous measurement of fMRI and continuous blood pressure in order to assess the impact of attention on immediate vascular responses to aversive stimuli.The proposed experiments are expected to shed light on deficient cognitive mechanisms of emotion modulation predisposing to EH. The use of cutting-edge measurement methods and advanced analysis is expected to provide much needed new data on how the brain controls reactions to aversive in