RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Catalysing Digitisation throughout Europe' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The project Smart4Europe responds to ICT-04-2017, Smart Anything Everywhere (SAE) Initiative, scope b), Coordination and Support Actions. In recent years innovation in products and services is to an increasing extent based on digitisation. Prominent examples are consumer products like smart phones, autonomous driving, Industrie 4.0 etc. Digitisation enables enhanced or new functionalities in most products and services. A key question is “How to optimise the transformation of this potential?” Especially SMEs need an easy access to digitisation technologies. Here SAE will help by pooling different offers in a one-stop-shop.The concept of Smart4Europe is to serve SAE at three levels: • the Commission• projects aligned to SAE and • all parties interested in SAE, with a focus on SMEs and mid-caps. The ultimate goals of Smart4Europe are to provide support in:• reinforcing the collaboration between projects supported under SAE• increasing their outreach and impact• providing wide coverage of stakeholders in technological, application, innovation, and geographic terms.In order to achieve this, Smart4Europe will expand an existing website to create an Innovation Portal, provide a service centre; facilitate brokerage; coordinate communication and dissemination activities; help in sharing best practices and experiences; create a Technology Radar to identify technologies SAE can benefit from; and last but not least, establish links to regional/national initiatives to leverage investments and stimulate growth.Smart4Europe is driven by a strong consortium of partners that have already demonstrated their commitment and engaged for several years in shaping the SAE Initiative. Under the SAE umbrella there will be a growing number of projects, focusing on different technology domains and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Activation and assembly mechanisms of the rhodococcus proteasome' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Proteasomes are essential components of eukaryotic cells and have also been found in prokaryotes. They play a key role in intracellular protein degradation and are composed of related subunits which fall into two families, named a- and B-type subunits. A general feature of all proteasome B-type subunits is a highly variable prosequence. We plan to explore the role of the B propeptide in the activation and assembly mechanisms of the Rhodococcus prokaryotic proteasome. It is an extremely useful research tool because it displays an intermediate complexity between the archaebacterial and eukaryotic complexes. A prime focus of our work will be to elucidate the mechanisms involved in the cleavage of the prosequence. The other major goal will be to investigate the potential role of the prosequence in targeting a B subunit to its a partner. These investigations will be performed by using multidisciplinary approaches combining recombinant DNA techniques, site-directed mutagenesis and electron microscopy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'An industry-led Forum for Innovation and Research in European Earth Observation' (FIRE) under Horizon 2020.

assistant: **Objectives**

As Europe’s Forum for Innovation and Research in Earth Observation, FIRE aims to build a strong community and a well-defined, recurrent process that will help to capture the “now” and to shape the “tomorrow” of the European EO sector. To achieve this overarching objective, FIRE will nurture the coordinated exchanges between innovators, policy-makers, technologists, businesspeople and researchers, towards designing a long-term Research and Innovation Strategy that will guide the development, delivery and uptake of EO services for the benefit of economy and society. The practical steps to get there are reflected onto the 4 specific objectives: O1: Build a community of research and innovation actors with the mission to keep a finger on the pulse of different market sectors that can benefit from EO-services enabled value. O2: Foster the coordinated interaction between the identified EO and non-EO actors, through a series of events and on-line tools. O3: Develop and implement a collaborative and integrated European research and innovation strategy that will guide the development, delivery and uptake of EO services. O4: Maximise the impact of project activities through a well-defined and appropriate communications strategy and a robust sustainability plan. These objectives are tackled through a Four Pillar approach of Collecting background information and relevant sector actors; Conversing with these actors and EO sector experts to identify EO target market pain points and developing a roadmap to ameliorate these pains through uptake of EO technologies; Collaborating with the broad existing network of GEO and Copernicus initiatives to maximise EU funding efficiencies; and Communicating the results of these discussions within the target market sectors and beyond through an exc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Providing Real Integration in Multi-disciplinary Environments', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The main objective of the PRIME project is to give business professionals a learning environment where they can experiment with new ideas and learn how to handle the entire life cycle of products and processes for all stakeholders of the organization. PRIME proposes to achieve this by enhancing current work environments with a new paradigm based on serious gaming. This will provide the means for learning by experience within a virtual environment that is safe and foments risk taking without detrimental impact on the business. The experience garnered is based on strategic management, including multi-stakeholder negotiation and business connectivity.  The technological objectives are: - The development of a virtual business environment based on a simulation model of strategic manufacturing; - The system architecture supporting the virtual business environment; - The development of a PRIME client that supports ubiquitous platforms and has flexible interfaces; - The design and development of intelligent virtual stakeholders; - The adoption of the intelligent virtual stakeholders technologies to develop agents that complement the user's activities in virtual business environment.  From these workpackages, the main project outputs will be:  - User requirements for the serious gaming approach - Specification of the software architecture - Functional specifications of the gaming environment - The PRIME toolset, software, and content library - Three pilot studies - Exploitation plan  The main impacts from PRIME are expected to be:  - Reinforcing competitiveness through training of professionals in various expected or unexpected scenarios - Reinforcing economic growth by allowing optimisation of business operations through simulation and evaluation of various scenarios - Reinforc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Harnessing Proto-Enzymes for Novel Catalytic Functions' (COMPENZYMEEVOLUTION).

assistant: **Innovation**

Enzymes are Nature’s catalysts, reducing the timescales of the chemical reactions that drive life from millions of years to seconds. There is also great scope for enzymes as biocatalysts outside the cell, from therapeutic and synthetic applications, to bioremediation and even for the generation of novel biofuels. Recent years have seen several impressive breakthroughs in the design of artificial enzymes, particularly through experimental studies that iteratively introduce random mutations to refine existing systems until a property of interest is observed (directed evolution), as well as examples of de novo enzyme design using combined in silico / in vitro approaches. However, the tremendous catalytic proficiencies of naturally occurring enzymes are, as yet, unmatched by any man made system, in no small part due the vastness of the sequence space that needs navigating and the almost surgical precision by which enzymatic catalysis is regulated. The proposed work aims to combine state of the art computational approaches capable of consistently reproducing the catalytic activities of both wild-type and mutant enzymes with novel screening approaches for predicting mutation hotspots, in order to redesign selected showcase systems. Specifically, we aim to (1) map catalytic promiscuity in the alkaline phosphatase superfamily, using the existing multifunctionality of these enzymes as a training set for the introduction of novel functionality, and (2) computationally design enantioselective enzymes, a problem which is of particular importance to the pharmaceutical industry due to the role of chirality in drug efficacy. The resulting theoretical constructs will be subjected to rigorous testing by our collaborators, providing a feedback loop for further design effort and methodolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deciphering translocation-based genome topology effects and their role in lymphoma formation' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

A central goal in cancer research is to identify the molecular mechanisms underlying tumor formation, such as translocations that result in expression of fusion genes or proto-oncogenes located at the translocation breakpoints. While the consequences of this erroneous expression have been widely studied, other effects of translocations remain largely unexplored. Nevertheless, these can provide vital new insights into tumorigenesis. I hypothesize that translocations disturb the global 3D genome architecture, causing alterations in chromosome territory positioning and interchromosomal interactions. And, that these can account for (in)activation of key genomic loci for which the cause of deregulation remains so far unknown. I will address this hypothesis in the context of Non-Hodgkin lymphoma (NHL)-related immunoglobulin (IGH) translocations. By genome editing we will create lymphoblastoid cell lines and cord blood cell-derived B lymphocytes in which IGH translocation-based effects can be cleanly dissected in vitro and in vivo. In these models, we will study how IGH translocations affect genome topology, the epigenetic and gene expression landscape and NHL formation. To that end, we will assess (i) chromosome territory structure and interchromosomal crosstalk by chromatin conformation capture and fixed- and live-cell imaging, (ii) epigenetic and gene expression maps using bulk and single-cell profiling and (iii) in vivo tumor formation. Importantly, after exploring the presence of the observed gene expression changes in NHL samples, we will target the coinciding changes in in vitro and in vivo approaches to probe their relevance for lymphomagenesis. Overall, LymphoTOP shall lead to deeper insights into translocation-based genome topology reorganisation and its role in tumo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Commercial feasibility of the Novio-PlainGel: a novel synthetic,  reversible thermosensitive, biomimetic hydrogel for organoid-based precision medicine' to be submitted under Horizon 2020.

assistant: **Abstract**

Noviocell BV is a highly innovative biotechnology company and builds upon its proprietary polyisocyanopeptide (PIC) hydrogel. This is a novel synthetic, reversible thermosensitive hydrogel for 3D cell culturing. PIC hydrogels uniquely perform like a natural biomaterial, while being fully reversible thermo-sensitive, which allows for ease of cell/tissue recovery and easy downstream processing after culturing. In addition, PIC hydrogel has a unique combination of bio-functionality and biomechanics that makes them excellent matrices for 3D stem cell culture. During OPTIMIsE, Noviocell BV will investigate the technical and commercial feasibility of using the PIC hydrogel as a platform for the clinical use of organoids (mini organs ex vivo). The use of organoids in a clinical set-up has the potential to open up unique possibilities for precision medicine, as it can facilitate organoid-based drug testing and provide disease specific models. However, their clinical use is currently hampered because of batch-to-batch variability, sub-optimal extracellular matrix,  small scale production and the risk of immunologic response and pathogen transmission (as they cultured in Matrigel which a basement membrane extract from mouse sarcoma). The PIC hydrogel, due to its unique characteristic, can address these unmet needs and facilitate the use of organoids for personalised medicine. The validation of  PIC hydrogel initially as the best hydrogel for growing organoids (using pancreatic organoids as a proof of concept) and at a later stage as a diagnostic platform in clinics will spur the profitability and growth performance of Noviocell BV. It is estimated that within 5 years after market introduction of the PIC hydrogel, Noviocell BV will have cumulative revenues of >€40,7 million (only
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A New Agenda for European Security Economics' (EUSECON).

assistant: **Innovation**

EUSECON analyses the newly emerging field of European security economics by identifying the nature and scope of this research field, by bringing together the leading European research players in this field and by building new analytical and conceptual insights on the most pressing research needs in this field. By implementing these research activities, EUSECON will establish an operational network of the leading European researchers in security economics, which in turn will enable research-based policy advice on economic aspects of security. In order to achieve these aims, EUSECON builds an integrated and collaborative approach, which will lay the foundations for the development of a new European multidisciplinary research agenda in security economics and security policy. The unifying theme of the proposed research are the human drivers of the new insecurity, that is terrorism and organized crime. Specifically, EUSECON analyses the causes, dynamics and long-term effects of both human-induced insecurity threats and European security policies. The approach will promote in-depth understanding of insecurity threats emerging from terrorism and organised crime with a view to uncover the much-needed information base for effective domestic and international security policy. In terms of proven research performance in this field and relevant past policy advisory activities, the sixteen members of the consortium represent the best economists and social scientists in this field in Europe today. It is expected that EUSECON will significantly advance the European research capacity well beyond the life.-time of this project, even vis-à-vis the currently strongly dominant American research capacity. This will also improve the long-term viability of the European policy making capacity o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Enhancing Competitiveness, Resilience and Sustainability of Remote Farming, Forestry and Rural Areas through Holistic Assessment of Smart XG, Last-mile and Edge Solutions’ Gains'.

assistant: **Innovation**

New trends such as teleworking and e-commerce, as well as the need for a further increase of digital tools in all sectors (i.e., health, education, transportation, farming, etc.) demanded by the Covid-19 pandemic, are pointing out once again digital territorial inequalities, supply-chain disruptions and deficiencies in economic opportunities that hamper resilience and prosperity of rural communities.  Accessibility and connectivity are key issues to mitigate this erosion of socio-territorial cohesion. However, identifying a common solution for equipping rural communities with increased access to services, opportunities and adequate innovation ecosystems ensuring that no one left behind is a challenging task, mainly due to the diversity of challenges and needs of different locations. In this respect, XGain fosters a sustainable, balanced and inclusive development of rural, coastal and urban areas by facilitating access to relevant stakeholders, such as municipalities, policymakers, farmers, foresters and their associations, to a comprehensive inventory of smart XG, last-mile connectivity and edge computing solutions, and of related assessment methods. The XGain overall project objective is, to deliver a Knowledge Facilitation Tool, facilitating business model development, supporting decision-making in the selection of an ecosystem of technologies, consisting of  connectivity options and edge processing solutions, by following a multi-actor and practitioner-oriented approach, and by coherently assessing their socio-economic and techno-environmental effects, aiming at: increasing systemic resilience and energy efficiency; contributing to climate mitigation; and reducing the digital divides between different types of citizens, farms, sectors and regions.


**Keywords:** XG
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Neuromorphic Flexible Electro/chemical Interface for in-Memory Bio-Sensing and Computing.'.

assistant: **Concept**

Efficient assessment of multiple bio/chemical and electrophysiology biomarkers directly at the area of interest is an indisputable asset in the individualized healthcare. However, current implantable systems and bioelectronic technologies still face limitations in ultra-sensitive bio-sensing, address the electrical and chemical aspects fragmentally, and depend on complex setups and computationally heavy off-line processing. Conventional von Neumann architectures face limitations in efficiently handling the increasing sensor output data that can be mainly attributed to the physical separation between sensing, memory, and computing units. Here the overall objective is to conceptualize a first-of-its-kind, miniaturized, and self-contained biosensing technology employing neuromorphic devices functioning as on-node sensors and processors (in-memory (bio)sensing and computing), in soft, flexible and bio-compatible materials and format. I will demonstrate this technology showcasing, in an in vivo animal model, a proof-of-concept implantable bio-interface that intelligently interrogates and classifies neurodegenerative disease-related bio/chemical and electrical biomarkers, coupled with active elements enabling precise adjustment of stimulation control parameters based on analog inputs. This technology holds great potential to advance our understanding and treatments of pathologies through multiplex electrical and chemical monitoring reducing the demands for power-intensive analog-to-digital conversion and computational processing. Furthermore, it paves the way for tailored interventions, laying the foundation for next-generation biomedical modulation systems.