RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'THOR: Organometallic Thorium Chemistry'.

assistant: **Concept**

Erli Lu is a young multi-award winning scientist of enormous promise and potential and his work is of the highest international quality with publications in top journals. He wishes to build on and apply his formidable array of scientific skills to this ambitious and innovative programme to develop the organometallic chemistry of thorium which is 50 years behind the d-block. Many textbook d-block examples are yet to be achieved for thorium so our fundamental understanding is poor.The PI has extensive experience in actinide chemistry providing a proven method. However, in respect of thorium a more detailed experience of metal-ligand multiple bonds is needed. Thus, the PI has the facilities and actinide expertise, but needs detailed metal-ligand multiple bond input to proceed. Lu brings unique metal-ligand multiple bond expertise but he is unable to progress on his own as he does not have prior actinide expertise.Thus, this Fellowship will exploit the synergy from pairing the PI with Lu and deliver high impact science, future textbook examples, and will further our knowledge of thorium to advance EU science against strong competition from the US in catalysis, magnetism, materials, and energy. This will give invaluable research training and knowledge transfer between Lu, the PI and his group, industry, and other research groups to spread excellence in training and research across the ERA.The PI will move into a new area of research and gain career opportunities. The Host will deliver higher quality research and access new internationally leading frontiers of research. Thorium research will make major step-changes relevant to sustainability and energy priority areas of catalysis and clean energy. The ERA will see a strategically important yet stifled area of research revived
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Rethinking sources and consequences of business cycles'.

assistant: **Innovation**

Up until 2006 most macro-economists held the view that combination of technology and monetary factors could explain the bulk of business cycles, and that overall business cycle fluctuations were not a major source of concern for policy (at least in developed economies and in the post-war).  The 2007-2009 crisis and its aftermath has radically shaken this view. First, most industrialized countries have experienced the largest and more synchronized downturn since the great depression and neither productivity nor monetary factors seem to have played a major role in it. Second the downturn has left profound scars on developed economies, in particular it has left a combination of high unemployment, large fiscal deficits, sluggish and unbalanced growth which are causing serious social discomfort together with political and international instability. The goal of this proposal is to better understand causes and consequences of the crisis. I intend to work on the 6 specific projects outlined below. All 6 projects are empirically motivated by the great depression and surrounding events, and all projects try to draw relevant policy implications from the analysis.On the causes of the 2007-2009 crisis:i)Wealth and volatility. The project explores the role of self-fulfilling demand crises as a drivers of business cycles. Main finding is that situation in which asset prices (in particular housing prices) are low makes the economy more vulnerable to these crises.ii)Spatial Business Cycles. Project shows that increase in unemployment did not hit all US counties at the same time but rather started in few counties and over time spread to neighbouring areas. We draw lessons for the importance of housing prices and other local factors in causing, transmitting and amplifying fluctuations.iii
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Twinning to skyrocket scientific excellence towards individual radiosensitivity prediction by raising the bar in knowledge transfer, networking, and technological innovation in radiobiology' (RadExIORSBoost).

assistant: **Concept**

Prostate cancer patients receiving radiotherapy (RT) may develop radiation-induced side effects, which significantly impact quality of life. One of the main challenges in radiobiology is to predict individual patient's normal tissue radiosensitivity to tailor personalized RT. Although the Institute for Oncology and Radiology of Serbia (IORS) is a highly specialized health, scientific, and educational institution it is necessary to develop a strategic action plan and sustainable knowledge transfer networking with top-class leading European institutions. Through the 6 Specific Objectives, RadExIORSBoost project aims to develop and implement institutional Scientific Strategy on radiobiology, to investigate individual radiosensitivity by transcriptome profiling, radiation-induced lymphocyte apoptosis, and measurement of DNA damage levels, to design a high-quality clinical study, and to raise the research capacity of IORS and partner institutions through 5 international workshops, 8 short-term visits, and 6 trainings. RadExIORSBoost project aims to strengthen the administrative and research management skills of IORS. RadExIORSBoost project realization will increase the scientific excellence of IORS to approach high-ranking partner institutions, Medical Faculty Mannheim, Heidelberg University (UHEI), Germany, the University of Leicester (ULEIC), United Kingdom, Medical University of Vienna, Center for Cancer Research, (MUW) Austria, and the Institute of Oncology Ljubljana (IOL) from Slovenia. Artificial intelligence-based models, such as machine learning may give directions towards the clinical application of peripheral blood mononuclear cell transcriptome, and list potential biomarkers predicting radiotoxicity, not only in cancer patients, but also in healthy individuals at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Advanced Technology for Holographic Storage'.

assistant: **Objectives**

Optical memories are one of the most promising data storage technologies, economically and technically. In 2002, around 500 million drives and 13 billion disks have been manufactured. Optical memories ideally combine media removability, random access and lowest media costs. However, the conventional bit-wise recording technologies are facing the basic diffraction limitation, which prevent to further increase the areal data density. A way to further boost the effective data density is volumetric storage, which is a unique feature of optics. Thanks to recent material and component technology advances, holographic data storage is now a viable solution to efficiently use the volume of a storage material. The objective of this project is to develop the technological basis for a new-generation, high-capacity, compact and cost-effective holographic data storage system. Specific key components such as laser sources, optical, opto-electronic components, electronics and media substrates will be developed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A coupled thermo-hydro-mechanical model for physically-based assessments of slope stability accounting for climate change' under Horizon 2020.

assistant: **Concept**

Climate change will alter the frequency and patterns of landslides, increasing the risk to people, infrastructures, and ecosystems in many regions worldwide. Scientists mainly draw this conclusion from predicted changes in precipitation, ice covers, sea level, and land use. The direct effect of temperature on slope stability is usually neglected, even though a mechanical failure in various soils appears to be dependent on their thermal state. Temperature-dependent behaviours in soils have been documented in several laboratory experiments and field studies. I plan to use for the first time a coupled thermo-hydro-mechanical (THM) soil model based on the theory of hypoplasticity to better quantify the effects of climate patterns on slope stability. By this model, implemented in an in-house code, I expect to be able to reproduce complex hydro-mechanical responses caused by changes of temperature, including effects on water pressures, water retention, and swelling/shrinkage. I will perform short- and long-term parametric analyses under climate scenarios, to compare the direct role of temperature with that of other forcings. In this way, I expect to quantify how much local warming/cooling and altered patterns of temperature can control some types of landslides, and consequently affect current landslide hazard assessments. I plan to investigate an actual case study as well, to verify the model performance under complex boundary conditions, and demonstrate its applicability to practical slope-scale problems. Finally, I will conceptualise an upscaled model, to unlock the possibility of regional assessments.  This project is in line with the EU strategy on adaptation to climate change as well as with the Sendai Framework of the UNDRR because, by improving the knowledge on the beh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Novel gas diffusion layer for PEM fuel cells' to be submitted under Seventh Framework.

assistant: **Abstract**

The objective of this research proposal is to generate a novel gas diffusion layer (GDL) which will be a combination of existing carbon paper and cloth GDLs to ensure effective water management in PEM fuel cell. Water management is one of the technological challenges which needs to be addressed to commercialise PEM fuel cell technology and for hydrogen energy based future. Commercial paper and cloth GDL’s are good at handling specific water profile as carbon paper can handle dry operating mode effectively and carbon cloth handles flooding effectively.  When fuel cells are deployed for automotive application they are subjected to wider operating condition depending on the load profile and hence there is a need to combine paper and cloth to obtain advantage of individual GDLs. The combined paper and cloth GDL will be achieved by two different means; first a bi-layer GDL will be developed by physically stacking paper and cloth GDL and compared with the performance of a conventional single paper or cloth GDL of equivalent thickness. Secondly hybrid paper-cloth GDL will be developed by directly coating slurry of chopped carbon fibers and resin on carbon cloth substrate followed by sintering. The properties of hybrid GDL will be determined as a function of coating thickness and hence the degree of hybridization will be optimized. The novel GDLs will be tested for their water management when subjected to European and Indian automotive driving cycles. The degree of hybridization between paper and cloth will be further refined for each of the driving cycles and knowledge obtained will be of greater interest for both European and the Indian community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Pilot implementation of process plant lifecycle' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The PIPPIN project is an essential part of a strategic programme directed at deriving competitive advantage from improved information management processes across the lifecycle of process plant assets.It aims to measure the business benefit from the improved utilisation and exchange of specific information between the design contractor and the plant owner-operator in real business situations.The results of the project are of three types a) the documentation and measurement of the business benefit and how it was achieved b) the software products that were developed to realise the benefit c) technical documents, which include the specifications of the requirements and the  solutions.The project is driven by the business requirement to improve information management processes, in particular ensuring lifetime data availability by standardising the meaning and relationships of data. The project builds on the work done to develop the Standard for the Exchange of Product Model Data (STEP - ISO 10303) and its application to the needs of the Process Plant Lifecycle. In particular it will develop prototype software which can be quickly converted to full function products, and utilise these on real live industrial products. These products will include Application Program Interfaces capable of producing STEP files to some conformance class of AP 221 and AP 227: but will also include an implementation of a database design as a data repository. Previous proof of concept demonstrators based on realistic business scenarios have indicated the potential for major business benefits in terms of reduced time to market, improved quality of information, and reduction in costs. The PIPPIN project will demonstrate these benefits in a real industrial environment using real software. This will hav
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Relevance of double strand break repair pathway choice in human disease and cancer'.

assistant: **Objectives**

Double strand breaks (DSBs) repair is essential for normal development. While the complete inability to repair DSBs leads to embryonic lethality and cell death, mutations that hamper this repair cause genetically inherited syndromes, with or without cancer predisposition. The phenotypes associated with these syndromes are extremely varied, and can include growth and mental retardation, ataxia, skeletal abnormalities, immunodeficiency, premature aging, etc. Moreover, DSBs play an extremely relevant role in the biology of cancer. Alterations in the DSBs repair pathways facilitate tumour progression and are selected early on during cancer development. On the other hand, DSBs are the molecular base of radiotherapies and chemotherapies. This double role of DSBs in both, the genesis and treatment of cancer makes the understanding of the mechanisms that control their repair of capital importance in cancer research.DSBs are repaired by two major mechanisms that compete for the same substrate. Both ends of the DSB can be simple re-joined with little or no processing, a mechanism known as non-homologous end-joining. On the other hand, DSBs can be processed and engaged in a more complex repair pathway called homologous recombination. This pathway uses the information present in a homologue sequence. The balance between these two pathways is exquisitely controlled and its alteration leads to the appearance of chromosomal abnormalities and contribute to the diseases aforementioned. However, and despite its importance, the network controlling the choice between both is poorly understood.Here, we propose a series of research lines designed to investigate how the choice between both DSBs repair pathways is made, its relevance for cellular and organismal survival and disease, and its po
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biomechancial Aneurysm Risk Assessment Trial' to be submitted under Horizon 2020.

assistant: **Abstract**

The formation of aortic aneurysms is the by far the most common aortic disease and its prevalence (1%-5% in the 65+ population) strongly increases with age. Expensive aneurysm repair interventions (about 60k per year in Europe) are performed in order to prevent aortic aneurysms from rupture. However, oversimplified criteria like the maximum transverse aortic diameter or the aortic expansion rate are used to indicate aneurysm repair. These criteria fail to provide patient-specific (individualized) treatment indication, such that many patients are treated without a reason and health care resources are wasted. In contrast VASCOPS’ A4clinics software allows a detailed biomechanical rupture risk assessment, and hence, allows prioritizing patients according to their individual risk of aortic rupture. The market volume for such diagnostic information is estimated to 12000k€ per year in Europe.  A4clinics is patented, CE approved and achieved already Technology Readiness Level 9. Despite first retrospective validation studies demonstrated the clinical benefit of the system large prospective validation is needed to fully convince clinicians and to commercially exploit the product. Consequently, the aim of this proposal is to develop a clinical validation plan for the A4clinics software, which is tightly linked to its successful large-scale commercialization. Key points are the definition of a targeted validation strategy and the installation of an effective network of clinical partners, who also should serve as national contact points for product commercialization. In addition early measures to gain awareness of the validation initiative and links to product distribution plans are investigated. The planning will be performed in collaboration with our clinical contact at Karolins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Brain meets spine: the neural origin of toddler’s first steps' (Learn2Walk).

assistant: **Concept**

A child’s first steps may be small, but they are a giant leap for its development. Children have an instinct to walk from the moment they are born – a 'stepping reflex' hardwired in their neural circuitry – but it typically takes about one year before they can start walking independently. In a pioneering work published on Science in 2011, I demonstrated that the coordinated muscle activation in neonate stepping is described by two basic activation patterns that are retained throughout development, and supplemented by two new ones that be-come manifest in toddlers.These seminal findings triggered profound questions: Is the development of new patterns an emergent property, indicative of spontaneously changing cortico-muscular interaction? Does locomotor impairment change the spontaneous character of this emergent property into a gradual one? With the proposed research, I plan to answer these questions by studying the interplay between brain and muscular activity at the onset of independent walking.The overarching aim is to characterize the emergence of independent walking in typically developing children and in children affected by cerebral palsy, and to identify an optimal rehabilitation strategy to promote normal walking in the latter. I plan to perform a combined analysis of brain and muscular activity in typically developing children, unraveling the detailed processes underlying the learning of walking. I will then elucidate the reorganization of cortical and cortico-muscular activity accompanying the altered development of walking in children with cerebral palsy. Finally, I will apply these results to the identification of optimal rehabilitation techniques for children with cerebral palsy.It is my long-term ambition to exploit fundamental insights into neuro-motor co