RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Systemic Effects on Metastasis - a look beyond the tumor' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

What would you do if you were diagnosed with pancreatic cancer? The chance that it would happen is not that high (life-time risk of 1/60), but neither is the chance to survive (10%). In addition, the quality of life as a patient is severely compromised by inadequate understanding of the metastatic process, and lack of targeted treatment options or biomarkers to individualize treatment, leading to severe side-effects despite lack of treatment response in most cases. To make a difference and challenge this disease, by appreciating the systemic nature of cancer, I propose to focus on the role of the liver, the main organ of metastasis leading to subsequent death, in pancreatic cancer. I recently demonstrated the potential of using liver-derived information to predict outcomes in pancreatic cancer patients undergoing resection for localized disease (Bojmar et al., Nature Medicine, 2024). With this proposal, I suggest that the liver plays an active role in the progression of pancreatic cancer, and that this can be used to inform on treatment decisions, thereby improving the survival and quality of life in this patient group. I will investigate this concept through a translational study led by my team to evaluate treatment decisions guided by liver-based diagnostics, aiming at directing treatment locally or systemically, based on the metastatic biology of the cancer. Improving our knowledge about this stage of the disease could provide a treatment-window and open the door for tailoring chemo- and immuno-therapy, based on the systemic nature of the disease. I am uniquely positioned to lead this study, with my previous experience from the U.S., leading the first study of the human “pre-metastatic liver” in pancreatic cancer patients. Now independently established with my transl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enhancing European Coordination for National Research Programmes in the Area of Security at Major Events' (2007-2013).

assistant: **Concept**

Enhancing European Coordination for National Research Programmes in the Area of Security at Major Events – THE HOUSE is aimed at strengthening the ERA on Major Events security by applying the research coordination tools/methodologies developed during seven years of activity within the projects EU-SEC and EU-SEC II. THE HOUSE builds on the assumption that Major Events are “windows of opportunity” to increase inter-agency/intra-agency coordination at national and regional level and they are suitable to have a long-lasting legacy on the national security planning of the hosting countries.Capitalising on the existing EU-SEC II platform of cooperation, THE HOUSE gathers a wide Consortium of 24 national public end-users. The main Consortium’s goal is to achieve a harmonised implementation approach to security research in the field of Major Events in Europe via the European House of Major Events Security (the House). The coordinated research resulting from the application of the House coordination tools/methodologies to specific Major Events in Europe will benefit the partners in terms of provision of a common European taxonomy, planning and evaluation standards elaborated to respond to the specific needs of the security end-users groups.In addition, THE HOUSE will foster the advancement towards the adoption of a common policing approach across Europe and will facilitate the practical implementation of the most recent EU policies in the field, such as the Stockholm Programme.As a complementary action, the proposed Consortium envisages studying the most appropriate framework to render the House a long lasting European tool and seeks to identify a European Coordinator for Major Events.Finally, the training services and dissemination activities undertaken by THE HOUSE will ensure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Self-Foldable Origami-Architected Metamaterials' under Horizon Europe.

assistant: **Concept**

Technological progress and increasingly environmental-related problems call for new cutting-edge design strategies to improve materials’ functionalities. The S-FOAM's challenge is to breakthrough metamaterial design by implanting origami/kirigami capabilities within architected cellular structures at different scales, thus bringing metamaterials to unprecedented mechanical performance. The resulting metamaterials will combine multistability, anisotropy, geometrical frustration, control of localized deformation, and ellipticity loss to achieve a new capability: self-foldability and shape-morphing induced by external stimuli. Unlike what happens in currently available origami, the location of the creases is not a priori imposed, but self-guided by ellipticity loss, occurring in the homogenized material, equivalent to the kirigami/origami, and self-controlled by embedding within the microstructure topological point and line defects. This introduces an unexplored field of research in which a material element will become able to mechanically react to actions from the surroundings through a direct change in its shape, thus reaching a configuration that optimizes its stiffness, strength, toughness, and, in a word, its environmental resilience. The research project S-FOAM will develop modelling based on the mechanics of solids and structures, numerical simulations, and experimental tools for the optimal design of origami/kirigami-lattice metamaterials. Applications are envisaged in soft robotics where grippers grasp and manipulate objects without damaging them, and in wearable devices where materials gently adapt to humans’ movements. Moreover, the design principle provided by S-FOAM is of great interest in developing adaptive medical devices and in maximizing solar power intak
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'INdependent LIving support Functions for the Elderly' in the context of a Horizon 2020 call.

assistant: **Objectives**

The number of elderly living with cognitive impairment is growing rapidly due to increasing life expectancy. The percentage of those who live alone depends upon the condition (i.e. roughly 30% of those diagnosed with dementia) but the majority would like to live in their own home or with family, provided that it is safe, comfortable, and cost effective. IN LIFE aims to prolong and support independent living for elderly with cognitive impairments, through interoperable, open, personalised and seamless ICT services that support home activities, communication, health maintenance, travel, mobility and socialization, with novel, scalable and viable business models, based on feedback from large-scale, multi-country pilots. Building on existing knowledge and tested AAL technology/services IN LIFE will offer 19 different services, which will be further optimised and adapted to the particular needs and wants of various elderly groups, including mild cognitive impairment (MCI), early dementia and cognitive impairment with co morbid conditions, plus formal and informal caregivers. These interoperable services will be integrated into an open, cloud- based, reference architecture to be tested in 6 Europe-wide pilots in Greece, Netherlands, Slovenia, Spain, Sweden, and UK, with over 1200 elderly with cognitive impairments, 600 formal and informal caregivers, and 60 other stakeholders. Attention will be paid to issues concerning multilingual and multicultural environments. The project will establish and extensively test new business models for a new taxonomy of elderly with cognitive impairments, encompassing those that are clustered as “dependent”, “at risk”, “assisted” or “active” and formulating and accessing new business scenarios, such as the “user-centric”, “service provider-cen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on '3D JETPEP - REVOLUTIONIZING HIGH-VALUE MANUFACTURING WITH MULTI-AXIS JET PLASMA FINISHING'.

assistant: **Concept**

Imagine a world where the tedious, time-consuming, and error-prone process of manually finishing metal precision parts is a thing of the past. At plasmotion, we are making this vision a reality with our groundbreaking 3D JETPEP technology. This innovative solution combines plasma physics, electrochemistry, and fluid dynamics to automate the polishing, deburring, and cleaning of metal parts with unparalleled precision and efficiency. High-value manufacturing industries, such as semiconductor, medical, aerospace, and analytics, are plagued by the inefficiencies of manual finishing processes, which are labor-intensive, time-consuming, and prone to human error. The dependency on skilled labor is a crucial bottleneck in precision parts production, leading to delays, increased costs, and inconsistent quality. Our 3D JETPEP technology addresses these challenges by automating the surface finishing process using environmentally benign saltwater electrolytes. This makes us 15 times faster than laser polishing and suitable for serial production. The global market for precision parts was valued at 178,4 B€ in 2024 and is projected to reach 894,6 B€ by 2037, with Europe expected to lead the industry. Our competitive advantage lies in the unique combination of plasma-electrolytic processing and jet-based application, offering faster processing times, unmatched geometric fidelity, and environmental sustainability. Our business model includes machine sales, electrolyte sales, and after-sales services, creating a continuous revenue stream. To achieve our goals, we seek blended finance from the EIC Accelerator program – 2,5 M€ in grant funding to develop and validate our technology, and 3,23 M€ in equity funding to support deployment and scaling. With the support of EIC, we can de-risk o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Per‐ and polyfluoroalkyl substances impact on reproductive health of firefighters'.

assistant: **Objectives**

Per‐ and polyfluoroalkyl substances (PFAS) are highly fluorinated compounds, with a variety of industrial and consumer uses, including stain resistant coatings, plastics, fire‐resistant coatings, and fire‐fighting fluids. PFAS are the active ingredient in aqueous film‐forming foam (AFFF) use to extinguish fuel-based fires. Potential links between the occupational use of AFFF by firefighters and certain negative health outcomes have not been sufficiently studied. As the overall objective of this study is to investigate the influence of PFAS newly identified in AFFF on reproductive health of firefighters, we will fully delineate PFASs composition found in AFFF and use by firefighters during their duties. We intend to characterize the composition of individual PFASs and their precursors in AFFF using unique analytical set up consisting of liquid chromatography-inductively coupled plasma tandem mass spectrom¬etry (LC-ICPMSMS) followed by high resolution mass spectrometry (LC-OrbiTrap -MS). We will perform sampling and analysis of blood and semen in newly recruited group of firefighters after their first exposure to AFFF to monitor the change in concentration levels of the compounds identified in the AFFF and evaluate the relations with fertility parameters (sperm count, morphology, motility), as firefighters are at higher risk to be diagnosed with male infertility. To directly compare in vivo observations and verify our findings we will set up in vitro experiments to elucidate the effects of these compounds on steroidogenesis and spermatogenesis pathways. The proposed interdisciplinary study is a major step in elucidating the role of PFAS originating from AFFF in male reproductive health. Moreover, these findings will also support efforts designed to introduce a more rigoro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of highly efficient solution-processable blue organic light-emitting diodes based on liquid-crystalline thermally activated delayed fluorescent emitter materials' (TADF-DLC-OLEDs), addressing dissemination and exploitation.

assistant: **Impact**

Recent years have seen tremendous advances in the area of vacuum-deposited organic light-emitting diodes (OLEDs) and these are now commercialized as displays in small portable devices, flat-panel full-colour televisions, and solid-state lighting sources for the automotive industry. The state-of-the-art emitters in these devices consist of a combination of fluorescent and phosphorescent materials, each of which has weaknesses in terms of performance and sustainability.  Thermally activated delayed fluorescent (TADF) emitters offer the potential to overcome these weaknesses. Vacuum-deposition fabrication processes are, however, both costly and materials-wasteful and it is also difficult and expensive to fabricate large-area pixels given the size of the evaporator. Solution-processed OLEDs addresses these detracting features of the fabrication process. The state-of-the-art solution-processed OLEDs, and in particular blue OLEDs typically show poor device performance both in terms of stability and external quantum efficiency (EQE) that is significantly worse than vacuum-deposited devices. This proposal addresses these specific issues using an innovative approach. We will develop solution-processable blue TADF emitters based on discotic liquid crystalline (DLC) molecules, which we contend will provide horizontal alignment in solution-processed films, something not possible at present, in order to improve the light-outcoupling efficiency and hence the EQE.


**Keywords:** Organic semiconductors, luminescent materials, horizontal alignment, liquid crystals, delayed fluorescence, organic light-emitting diodes, electroluminescent device, solution-processing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SPEcification, Analysis & Re-calibration of High Energy pArticle Data' (SPEARHEAD).

assistant: **Concept**

Through a detailed analysis of very high-energy particle observations from the most important heliophysics missions combined with ground based measurements, SPEARHEAD will provide answers to three science questions:1) How are protons accelerated beyond 100 MeV and electrons beyond 1 MeV in solar eruptions?2) What are the release times and spectral characteristics of near-relativistic particles from solar eruptions?3) How do coronal and interplanetary structures affect the transport processes of very high energetic particles?To enable the scientific data analysis SPEARHEAD has three technical objectives:1) Determining the response functions of a large number of spacecraft instruments to derive high-energy particle fluxes from observations at unprecedented accuracy releasing revised and completely new datasets2) Performing cross-calibration of datasets measured by science-grade and monitoring instruments to enable the use of monitoring data for scientific analyses3) Combining high-energy particle and context observations together with modeling of plasma structures for easier in-depth analysis of solar eruptions, quantifying their effect and delivering them to the community.SPEARHEAD combines eight partners possessing the best European resources (in terms of data, models and infrastructure) in very high-energy particle research into a consortium that will deliver answers to the three science questions and consolidated datasets, methodology and open access tools to the community enabling breakthrough science on these open problems. The work is organized efficiently in 8 work packages with carefully picked top European expertise in each of them. SPEARHEAD will also facilitate the future application of its results through dedicated and comprehensive user engagement, direct pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Impact of medical drugs on the evolution of human microbiome function and antimicrobial resistance development' (DIMEvAR), addressing dissemination and exploitation.

assistant: **Impact**

The human gastrointestinal tract harbors trillions of microbes, known as the gut microbiota. This microbial community helps modulating developmental, immunological, and metabolic functions of the human host and it plays an important role in medicinal drug response. Several works showed the bidirectional relationship between the gut microbiota and drugs. Medication modifies microbiome composition both in vitro and in the human gut. Further, commonly used drugs influence the microbiome metabolic functions and increase the abundance of antimicrobial resistance (AMR) genes in human cohort studies, suggesting that non-antibiotic drugs could contribute to the emergence of AMR. At the same time, microbiome-encoded enzymes can metabolize a wide range of medical drugs, participating in both beneficial and adverse effects. Considering that many drugs are used over extended periods of time to treat chronic diseases, long-term exposure to drugs may likely drive microbiome evolution. This could influence and evolve metabolic properties of gut microbes and lead to the emergence of novel AMR.This project aims at better understanding the impact of long-term exposure to medical drugs on human gut microbiome evolution at the phenotypic and metabolic level, the underlying molecular mechanism, and their consequences in vivo. Based on previous data and in analogy to well-understood antibiotics, I hypothesize that non-antibiotic drugs might induce stress-triggered microbial evolution. The project follows three specific objectives: (i) Quantify the impact of drug-induced evolution on microbiome metabolism and antibiotic sensitivity; (ii) Determine the role of bacterial stress responses in microbiome evolution; (iii) Assess drug-induced microbiome evolution using gnotobiotic mouse models. If s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Stratospheric regular soundings' (1994-1998).

assistant: **Concept**

a) to measure regularly and simultaneously the vertical distribution of several source gases (CFCs, H2O, N2O) together with ozone, NO2, OClO, BrO, background and volcanic aerosols, temperature and pressure, at three latitudes in the lower stratosphere, from the tropopause up to 30 km, using relatively cheap and small balloon borne instruments; b) to combine the results of the above measurements with those of instruments in orbit for the upper levels for retrieving the complete stratospheric profiles of the species; c) to simulate the results with 3D CTM and Lagrangian photochemical models to differentiate the transport and chemical terms.The approach is to fly a combination of light instruments below relatively small volume (5.000 or 10.000 m3)  and easy to operate balloons which can be launched on short notice as successfully demonstrated during EASOE  and SESAME. The flight train will associate the following instruments: -the SAOZ payload from CNRS: uv-visible spectrometer, 22 kg including a Global positioning System, an ARGOS beacon, temperature and pressure sensors, for remote measurements by solar occultation of ozone. NO2, OClO and BrO by uv-visible spectrometry and tentatively, H2O and CH4 with a IR spectrometer at 1.6 5m;  -the instrument DESCARTES of the University of Cambridge (20 kg, no telemetry) for in-situ sampling of CFC-11 and CFC-12, CFC-113, N2O and possibly CH4, analysed by gas chromatography after the recovery of the payload;  -the Laser Backscatter sonde LABS of the Italian CNR-IFA (6kg), for in-situ measurements of the aerosol backscattering ratio and polarisation (liquid vs solid particles).  They will be launched at three or four sites:  -at the Norwegian Andoya Rocket Range (69 N);  -at the French CNES balloon centres of Aire sur l'Adour (fall t