RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Language origins and grounding: simulating the transition from holistic to compositional languages' (LOGHOLTOCOM).

assistant: **Concept**

This project involves research into the origins and evolution of human language by using computer simulations. The research will concentrate on the following question: Have the underlying principles of language arisen through biological evolution or through cultural evolution? If language has evolved through biological evolution, the human genome should capture certain aspects of human languages. If it has evolved through cultural evolution, languages must be shaped through the interactions between humans rather than through biological adaptations. Within these two positions, the project focuses on the evolution of two particular aspect of human language, namely its compositional structure and its grounding in reality. In language expressions are composed of meaningful parts that can be recombined in other expressions; compare, for instance, the expressions the red square" and "the blue square", where "the square" is composed with "red" and "blue". This is compositionality. Grounding relates to the question how the meanings of utterances relate to the real world phenomena they stand for. For instance, how does a language user know what "the red square" means? The research will be carried out using computer simulations in which a population of virtual robots will try to develop a language from scratch in order to communicate events that take place in their environment. We will investigate the question of whether language evolved culturally or biologically by developing two studies. In the first study no biological evolution will be used, but the robots will use communicative interactions and individual learning mechanisms to develop and transmit linguistic knowledge from one generation to the next. In the second study, where we investigate biological evolution, we will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Non-invasive solution for periodontal and peri-implant diseases' (INPERIO).

assistant: **Innovation**

Nanoker Research, S.L has identified a potential business in dNanoker Research, S.L has identified a potential business in developing and promoting global dental solutions of the highest quality for patients with periodontal or peri-implant disease, which is the most prevalent form of bone pathology in humans, affecting 50% of the entire adult population. Nanoker has developed an aesthetic, mechanically reliable and tissue friendly all-ceramic dental reconstruction solution at TRL6 that prevents periimplantitis; in 2016, the global market value of dental implants and prosthetics reached 6.175 M€, with an estimated compound annual growth rate (CAGR) of 7-9% for the next few years. Nanoker has the potential to become the only company in the world with an available, long-lasting, non-invasive dental solution for periimplantitis patients. This solution is expected to obtain around 0.49% of the dental implant market share 3 years after project termination, and around 1.13% (133 M€) of the dental implant market share 5 years later. Thus, in only four years, Nanoker could reach a turnover of +47.3 M€ with a production capability of 100,000 implants-abutments/year and an accumulated EBITDA of +33.9 M€ (over four years). To remove the last dental health market barriers it is necessary to make a final investment in terms of product industrialization and certification, as described in this proposal, to become known and worthy to key opinion leaders. In this regard, this project, with a total budget of 4,370,373.75 € covers the expenses related to: a) the successful industrial-scale development of a set of dental prosthetic components made from a coated and highly resistant ceramic nanocomposite; b) performing a Clinical Validation; c) business growth, through two different distrib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mechanisms of cell Death and Disease: Advances in Therapeutic Intervention' in the context of a Fifth Framework call.

assistant: **Objectives**

The field of apoptosis or programmed cell death research remains among the most rapidly advancing areas in the biomedical sciences. As a consequence of this interest it is widely appreciated that inappropriate or disordered cell death contributes to the pathogenis of many common diseases including cancer, auto-immunity and neurodegenerative diseases. This appreciation has recently enabled new therapies to be developed and implemented. This meeting will focus on therapeutic targets, which have been recently identified based on mechanistic studies in the field of cell death research. Importantly, current information will be presented from clinical trials designed to assess feasibility and efficacy of cell death manipulation for therapeutic effect. The conference will bring together a multidisciplinary and internationally recognized group of scientists and clinicians to focus on the issues of new therapy development in this context. Therefore, the emphasis of the meeting will differ from other cell death speciality conferences whose focus is primarily linked to molecular and biochemical studies of cell death regulation. Because of the enormous interest and investment on the part of commercial biotechnology and pharmaceutical companies in this area, it is intended that this conference will facilitate interaction between scientists, clinicians and industry. We hope to facilitate the participation of younger European scientists, thus giving them the opportunity to make new professional contacts among the different partners interested in the development of therapies based on the manipulation of cell death and to contribute to the development of novel transdisciplinary research projects involving basic, clinical and therapeutic science.It is hoped that one outcome of this inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Functional and structural analysis of the mammalian nonsense-mediated mRNA decay pathway' (NMDpaths) targeting Seventh Framework.

assistant: **Abstract**

Nonsense-mediated mRNA decay (NMD) is an important quality control pathway conserved throughout all eukaryotes: mRNAs which contain premature stop codons (PTC) are detected and committed to accelerated decay to protect the cell from deleterious effects of truncated proteins. NMD also controls abundance of many wild-type genes that contain features recognized by the NMD machinery. Due to the important tasks of NMD, its proper functioning is essential for embryogenesis in vertebrates. Furthermore, NMD plays a prominent role in carcinogenesis and is involved in several genetic disorders.The core NMD factors are identified and a picture of the steps involved is emerging. However, the exact interactions of the NMD factors, the order and orchestration of the processes, and the connection between PTC-recognition and mRNA decay remain unclear. In fact, detailed knowledge about NMD is necessary for drug development and more generally might reveal aspects of control and interactions in complex pathways that could be transferred to other systems.I will dissect the interactions between factors that come into play after PTC-recognition, namely Smg5, Smg6, Smg7, Upf1 and the phosphatase PP2A. First, I will define their interacting domains by co-immunoprecipitation from human cells. Subsequently, I will reconstitute the complexes in vitro, determine binding affinities and try to solve their crystal structure. Mutations that disrupt these complexes will be used to test their role in NMD in vivo. The effect of Upf1-phosphorylation on these interactions will also be investigated. Furthermore, I plan to identify factors that connect PTC-recognition to the general mRNA degradation machineries by a co-immunoprecipitation screen from human cells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of ultrafast mri techniques for functional and physiological brain imaging' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Sub second 3D imaging with high spatial resolution and full brain coverage is desirable in assessing cerebral physiology by MR techniques. An ultra fast 3D MRI sequence will be developed and applied to single-event functional MRI for microsurgical planning and management of acute stroke patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Analytical Wall-function Approach and Large-Eddy Simulation' (AWALES), addressing dissemination and exploitation.

assistant: **Impact**

The proposed research aims to develop and apply advanced computational methods of handling the near-wall region of the fluid flow within the Large Eddy Simulation technique, which is increasingly being adopted by industrial researchers in safety studies of nuclear energy plants and other applications. Despite the fact that Large Eddy Simulation (LES) offers an extremely accurate resolution of free unbounded fluid flows, the near-wall regions that drastically affect heat transfer rates impose a great challenge for LES, due to the very high computational cost of resolving the small turbulent eddies which occur there. Therefore in the vicinity of walls LES often employs wall functions, which are used to evaluate the resistance of the near-wall viscous layer to heat and mass transfer. Unfortunately, the conventional wall functions, which are employed in LES, have considerable limitations in terms of accuracy due to inherent assumptions that are built into them.New wall functions (referred to as AWF), have recently been developed by applicant for use within Reynolds-averaged simulations, and these have proved to be widely applicable since they are based on the analytical solution of Reynolds equations and are not dependent on the prescribed velocity profiles. This allows the AWF to account for many important physical effects that take place at near-wall flows. To date this strategy has been developed and applied to a significant range of flows within a Reynolds Averaged Navier-Stokes (RANS) framework. The main objective of the research project will be to extend and validate the AWF treatment within an LES methodology. Given the improved physics embedded within the AWF, this will equip academic and industrial researchers with a powerful and affordable tool in resolving heat a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Modelling of human body and protective textiles for estimation of skin sensorial comfort and life risk of fire-fighters working in extreme external conditions', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The objective of this IOF project is the application of finite element method (FEM) to model a digital human body (Avatar) while wearing virtual protective textiles (PTs) in order to estimate human skin sensorial comfort and life risk conditions in varied extreme external conditions, like heat, flames.The methodological context focuses on: 1) achievement of realistic human simulation (RHS) in Abaqus programme and estimation of human tissue compliance and stretch resulting from contact with PTs as well as heat stress conditions; 2) estimation of divergences between the results of laboratory wear comfort and burning tests on manikins and finite element model simulation of human torso covered by PTs.The proposed IOF project will contribute to advancement in non standard measuring techniques for investigating the interaction between human body and textiles. It will also seek to tease out the mechanisms of comfort equilibrium, skin sensorial wear comfort and prediction of comfort basing and life risk of fire-fighters, which is the novelty.The project entails a sizable training-through-research component that coexists with research plan as well as enables me to strength my international position as a scientist and to establish an independent position, which have been taken into account while designing my Personal Career Development Plan.The European host in this project is Ghent University (Belgium) and the third country host is North Carolina State University (USA). The choice of both universities is based on unique combination of top-drawer research units in tangible research domains which together sustain the ideal environment for carrying out the proposed research project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integrated study of skin resident Memory T cells and dermal mononuclear phagocytes in the fight against PATHogens' (METAPATH) under Seventh Framework.

assistant: **Objectives**

"Integrated study of skin resident Memory T cells and dermal mononuclear phagocytes in the fight against PATHogens""Control of pathogen infection requires the generation of a tightly regulated immune response that recognizes the invading pathogen and that limits a potentially harmful host response. Recent work highlighted that resident memory T cells (TRM) form a very potent means of establishing effective immunity against infection. In the skin, I contributed to the extensive characterization of mononuclear phagocytes and unveiled the phenotype and some of the functions of the dermal macrophage subsets as well as the different dendritic cell subsets. In the present proposal, I propose to study the role of those different antigen presenting cells in the generation of TRM cells in the dermis upon a first pathogen encounter and their role in the re-activation of those TRM cells upon a second encounter with the pathogen. Learning the mechanisms by which efficient TRM cells are generated in the dermis will be an important step in the design of rational approaches to achieve the appropriate control of the pathogen at the site of infection.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Logic-based Verification of Privacy-Preservation in Europe's 2020 ICT' in the context of a Horizon 2020 call.

assistant: **Objectives**

In line with the EU 2020 Flagship Initiative on a Digital Agenda for Europe and the upcoming EU Cybersecurity Strategy, the goal of the LV-Pri20 project is to aid our ICT-driven lives, by “safeguarding the human right of privacy in the digital society”. Concretely, the main focus of LV-Pri20 is the formal and automatic analysis of privacy-preservation in today’s ICT. LV-Pri20 will focus on the prevalent wireless media, e.g., RF-identification protocols, remote car-unlocking, wearables, machine-to-machine communication in the Internet of Things (IoT)/ubiquitous computing, but it will not neglect wired environments (given their common cloud-connection). LV-Pri20 will assess and automatically analyse privacy-sensitive applications, in their standalone execution, as well as in the more involved setting of multiple, concurrent executions thereof. This will be done systematically and taxonomically: distinct classes of applications (e.g., identification protocols using Electronic Product Codes vs. the Open Smart Grid Protocol) and different privacy properties (e.g., data non-leakage vs. data-user unlinkability) will be respectively analysed via tailored, well-defined techniques. To specify privacy, LV-Pri20 will design/refine different non-classical logic languages which have inherent semantics for privacy-like expression (e.g., strategy logics). For these, we will then develop new model checking algorithms. All will be incorporated in automatic verification software, which already proved efficient in analysing highly distributed systems, inline with, e.g., the IoT applications envisaged herein.LV-Pri20 will have a multi-disciplinary, collaborative nature, an academic core and industrial side. After an initial privacy scrutiny, new/patched RFID-based, privacy-preserving, commu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Set up and comparison of multiple stem cell approaches for kidney repair' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

With the increasing rate of end-stage renal failure and limited alternatives for its treatment, potential regenerative approaches for kidney damages are urgently needed. Because of the complexity of the organ, the development of stem cell therapies for kidney is still in its infancy. Identifying which cell types are capable of beneficial effects is the critical step required to realize the potential of this therapeutic approach. Three possible sources of stem cells can be envisioned for the development of this type of treatment: (i) bone-marrow-derived stem cells, (ii) renal adult stem cells, and (iii) fetal renal stem cells. The focus of this project is to assess the regenerative potential of stem cells derived from different sources and investigate the possible obstacles to their utilization, as well as their potential side effects in preclinical models of acute and chronic renal failure. Indeed, the clinical usefulness of the treatment, as well as the need to understand currently discrepant results, require comparative experimental studies that have never been performed before either in SC therapy of kidney injury, or in that of other organs. Hopefully, this comparison will allow to set up standardized protocols of SC isolation and administration for phase I/II trials in patients affected by acute and chronic renal failure.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Collective dynamics in particle laden lamellae' (PARLAE).

assistant: **Innovation**

Particle laden fluids are of fundamental and contemporary interest due to the recent perspectives of understanding their flows. This research project endeavors to understand the collective behavior of solid particles suspended in fluid lamellae at multiple scales with relevance to aqueous foam. We aim to delineate the concurrence of distinct influences that have thus far been primarily studied in either bulk or single interface studies. These aspects include recent perspectives such as particle jamming in granular media, shear banding/localization in colloidal systems, aggregation dynamics, transitions from thermal to athermal dynamics and the influence of surfactant physical-chemistry. While these phenomena have been studied in 2-dimensional and 3-dimensional spaces, the influence of curved spatial manifolds is expected to exhibit novel and rich phenomenology. Fluid lamellae in are ideal candidates to study many of these phenomenon as a function of spatial curvature. Particle laden foam is also recently being used as precursors to building solid materials. The control of many aspects of the fabrication process relies on an understanding of particle dynamics at the lamellar scale. The proposal outlined here will understand fundamental mechanisms involved in these processes. In the return phase(India), we propose to further the understanding of foam in along with particle inclusions in the regime of impacts. This is expected to be a productive avenue of research as foam and particle inclusions can have multiple relaxation times. At low velocities (impact time >> material relaxation time), impacts are expected to distribute energy over a wider area of the target, however at high velocities (impact time << material relaxation time) the energy is strongly focused at the poi