RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The Transformation of Post-War Education: Causes and Effects'.

assistant: **Objectives**

The educational context that children are born into dramatically shapes their life chances, affecting not only their future economic well-being but also their propensity to participate in civic and political life. That education matters is hardly a new insight; however, an increasing body of research points to the importance of varying educational contexts on a range of outcomes. Despite these insights, we have little systematic comparative data on the educational contexts in which most the current adult population was actually educated, the political determinants of these contexts, or their long-term impact on a range of social and political outcomes. SCHOOLPOL proposes three innovative and high-reward work streams aimed at filling these lacunae. It will create the first systematic database of a) educational policy from 1945-2015 and b) regional educational performance from 1980-2015 across advanced democracies. Building on insights from both sociological studies of educational choice, economic analyses of geographic sorting, and recent work in political science on educational investment, SCHOOLPOL will reshape our understanding of education politics, showing how broad public objectives (growth, equality) in educational provision interact with the private objectives of organized groups and voters in particular communities to shape different distributions of educational resources and quality. Finally, SCHOOLPOL investigates the consequences of earlier political choices over education on long-term social and economic outcomes, examining the link between varying cohort educational experiences and social mobility and political participation using new and existing surveys. This innovative project breaks new ground in both the study of education and advanced political econom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Light assisted single electron manipulation' (LASEM).

assistant: **Innovation**

The aim of this project is to develop new technique that allows single electron manipulation by the light. The novelty of the project is to take advantage of the unique capabilities of carbon nanotubes for single electron detection to study electronic properties of various types of molecular systems subjected to external light source. To do this a novel nanodevice layout consisting of the carbon nanotube (CNT) combined with quantum dots or molecules is proposed. In the device layout the CNT is acting as a ultra-sensitive detector for single electron detection and the quantum dot is attached to only one electrode – a nanotube. Two configurations of the device layout are proposed. In the first scenario the nanotube and the probed molecule are laying on an insulating oxide surface and in second scenario the device is suspended. This layout overcomes problem seen in standard devices where a molecular system is placed between two electrodes and very often it turns out that it is impossible to pass any measurable current through the system.Detection scheme is based on the fact that electrons can tunnel between the quantum dot and the tube detector. Electron transport between these nanoobjects will be controlled by light illumination and it will be detected by means of electron counting spectroscopy technique. The proposed idea represents a new strategy to study the separation in energy between the electronic discrete levels of the quantum systems subjected to the light illumination.Another aim of the project would be to investigate the effect of light on the transport properties of molecules that can undergo structural and electronic modification upon light exposure. Upon light exposure some molecules can undergo a process that results in change of the shape of the molecule.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Running in the FAMILY -  Understanding and predicting the intergenerational transmission of mental illness'.

assistant: **Concept**

Mental illness runs in families. The FAMILY consortium aims to improve the life of mentally-ill persons with novel prediction models that are based on better understanding the mechanisms of intergenerational transmission of mental illness. The objectives are to improve causal understanding and gain prediction power from the family context by the innovative combination of statistical modelling of genetically informed designs, causal inference, multimodal and multilevel normative prediction, and molecular mapping, brought by world-leading neuroscientific expertise of the consortium, and address key bioethical and social issues raised by the concept of intergenerational risk transmission and risk prediction. FAMILY will bring together the largest existing human (epi)genetic and neuroimaging datasets from both within-family population cohorts and familial high-risk offspring studies, as well as utilise innovative animal models to shed light on pathways underlying intergenerational risk transmission. FAMILY will focus specifically on risk for mood and psychosis symptoms and diagnoses. In-depth causal analyses of how and when risk for mental illness occurs will help identify early risk and resilience factors and predict who is likely to be diagnosed or develop symptoms of mental illness. Advanced insights can uncover new targets for the development of preventive strategies to break the intergenerational cycle of mental illness and to support strengths and resource building. An immediate benefit will be to open direct translational perspectives to mental health care professionals by providing new (family-based) risk prediction tools for the early identification of adults and children at risk and to deliver ethical guidelines to guide its implementation. This will accelerate pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Engineering of the cellular quality control systems in bacillus subtilis for the production of high value-added proteins' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The Bacillus protein secretion machine contains cellular quality control systems that efficiently remove misfolded or incompletely synthesised proteins. Paradoxically, these quality control systems represent a major problem for the production of heterologous proteins at commercially significant concentrations. The ultimate objective is to develop a set of super-producer strains. Full use will be made of recent advances in genomics (eg.: DNA arrays), proteomics, bioinformatics, directed molecular evolution and information obtained from previous, EU-funded programmes on Bacillus protein secretion, genome sequencing and the systematic gene fuction analysis. The proposal includes the potential to 'spin-off a research-based biotechnology SME or trust company.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Stepping into the light: exploring mono-ADP-ribosylation through super resolution STED microscopy' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

ADP-ribosylation (ADPr) is a key post-translational modification catalyzed by the ADP-ribosyltransferase (ART) superfamily, including poly-ADP-ribose polymerases (PARPs), which, despite their name, can transfer either a single (mono-ADPr) or multiple (poly-ADPr; PAR) units of ADP-ribose to their targets. This process occurs in response to various biological and pathological stimuli, regulating numerous cellular functions. For many years, research in the ADPr field focused primarily on poly-ADPr PARPs, often overlooking the physiological importance and therapeutic potential of mono-PARPs. Recently, the development of new reagents, including versatile antibodies to detect mono-ADPr, provided essential tools to finally explore this elusive modification. Emerging evidence, partly obtained by using these antibodies, suggests that mono-ADPr responses could be promising therapeutic targets for immune-related diseases, pushing mono-ADPr into the spotlight. However, this growing pharmaceutical interest contrasts with our limited understanding of the molecular mechanisms and biological functions of mono-ADPr and the catalyzing enzymes. In this MSCA project, I aim to shed light on the functions of the underexplored mono-ADP-ribosylation by pioneering the development of super-resolution microscopy methods to visualize mono-ADPr localization across different cellular structures. Through this cutting-edge approach, my research will provide unprecedented insights into the spatial dynamics of mono-ADPr, potentially uncovering novel aspects of its functional roles in cells and providing powerful new methods for the ADP-ribosylation field. Additionally, I will investigate the crosstalk between two PARPs that, according to preliminary data from the host lab, may collaboratively mediate AD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Software development process improvement experiment'.

assistant: **Concept**

MAZ is a development and system house founded in 1990 by the Free and Hanseatic City of Hamburg. The main objective of MAZ is a product oriented technology transfer in the area of microelectronics applications. MAZ has undergone a BOOTSTRAP assessment in December 1994. As a result of this a quality system based on the V-Modell is currently being installed, which will improve the software development process significantly. Within this PIE, the reachability of the next milestone, i.e. introduction of OOA/OOD and configuration management methodologies, procedures, and techniques, shall be evaluated. If the PIE is successful these techniques will be trained and used throughout the department.THE EXPERIMENTThe experiment will be carried out in five major phases. During Phase I all organisational issues of the project will be settled. Phase II deals with the selection of appropriate methods and tools. A first introduction of the selected methods and tools in context of a strategic baseline project will be executed in phase III and evaluated. Phase IV is concerned with a broader introduction. The latter two phases comprise extensive training for the staff members and augmentation of the software production guidelines and the quality manual. During Phase V a BOOTSTRAP assessment will be carried out in order to evaluate the results of the experiment. The baseline project is a system for knowledge-based machine monitoring, fault diagnosis, and maintenance support (known as DiaMon). The software for this system is developed in C++ using the object-oriented paradigm. The software is consisting of roughly 120 modules, 20 percent of which are multiply reused under different configurations. The experiment will focus on this latter part of the software because this part would benefit m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reliable and scalable procedures for the isolation and loading of extracellular vesicles' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Exosome-based therapies are among the hottest topics in biomedical research, driven by the unique properties of exosomes regarding stability, low immunogenicity, prolonged circulation and especially, selective targeting. In 2022, over 50 clinical trials using exosomes for therapy were under way, in diseases ranging from cancer to diabetes to central nervous system disorders. However, both current research on exosomes and their future translation into clinical therapies are hindered by two significant problems. The first is the isolation of exosomes (and of extracellular vesicles in general), a highly challenging task due to: i) the high complexity of the body fluids that contain them, and ii) the delicate nature of exosomes themselves: soft entities of 50-150 nm whose membrane is responsible for key properties and must be preserved. Ultracentrifugation, the standard isolation method, has clear limitations: low yields, impurity of the products and damage to exosomal membranes due to long processing times at high g. While numerous alternatives have been commercialized (size, affinity and precipitation-based methods), these issues remain unsolved. The second problem relates to the loading of therapeutic agents (nanoparticles, drugs, siRNA, miRNA), into exosomes without damaging their membranes, another challenge without a solution today. LABORIOUS leverages the experience gained in AdG CADENCE to propose innovative solutions. A novel tangential filtration procedure will segregate exosomes by size, removing impurities and minimizing pressure-induced membrane damage. Also, a pioneering continuous electroporation system will provide unprecedented control, allowing the load of therapeutic cargo with minimal membrane disruption. Results will be closely monitored for patenting a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Strategies and tools for Real Time EArthquake RisK ReducTion' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Earthquakes are a serious threat for many European countries, particularly those around the Mediterranean Sea. In many cities exposed to high earthquake hazard, a substantial proportion of the population still lives in buildings that do not meet modern earthquake-resistant standards.  Preventive actions, such as retrofitting of structures, are essential, but they are not sufficient and cannot be applied easily on a large scale.  Real-time actions focussing on decreasing the physical vulnerability and exposure of populations are a viable way to reduce earthquake risk.The primary objective of REAKT is to improve the efficiency of real-time earthquake risk mitigation methods and their capability of protecting structures, infrastructures and populations.  REAKT aims to develop methodologies that will enhance the quality of information provided by earthquake forecasting, early warning and real-time vulnerability systems, as well as establishing best practices for how to use all of this information in a unified manner.  In order to be used effectively, such information needs to be combined into a fully probabilistic framework, including realistic estimates of the uncertainties involved, that is suitable for decision making in real time. The REAKT consortium draws together most of the main European institutes and research groups, in addition to major non-European institutes, that are working on different aspects of earthquake early warning and probabilistic models of operational forecasting.  The project is divided into 7 scientific work packages that constitute a logical sequence from, at one end, the processes involved in earthquake generation and the physics of short-term seismic changes, to the other, the threatened people. through operational earthquake forecasting, early
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Idea, Ideal, Idyll: Garden Cities in Central Europe 1890s-1930s'.

assistant: **Concept**

This project examines processes of cultural and intellectual exchange between Britain and Central Europe, with particular regard to ideas of urban and architectural design. It focuses on the utopia of the garden city, invented by Ebenezer Howard in the classic work To-morrow: A Peaceful Path to Real Reform, published in 1898. Howard sought not only to reform architectural design, but also to effect social change through facilitating new forms of communal living, including the role of women. Soon after, the first garden cities were built in Britain. It is generally accepted that the visions of British thinkers and designers such as Howard was influential in central Europe. However, beyond Germany, the impact of British ideas and practices in central Europe has only been studied in a schematic way. This project therefore interrogates the transfer of ideas from Britain to central Europe in the late 19th and early 20th centuries, their implementation, development and application in particular, garden towns and garden suburbs. Its main focus is on the Czech and Slovak lands (part of Austria-Hungary before 1918, afterwards, Czechoslovakia), but it also makes comparative reference to Austria and Germany. Equally, the project examines how urbanist ideas from central Europe were then transferred back to Britain, in the form of the company town built in East Tilbury in England by the Czech shoe company Baťa in the 1930s.It will be the first systematic and comparative study to take into account not only the local national context (as well as that of the German speaking countries), but also the wider networks of ideas and practices that were in circulation. As such, it asks a key question: How and why were the utopian ideals of English garden cities “translated” into the Czechoslov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Translational and Functional Onco-Genomics: from cancer-oriented genomic screenings to new diagnostic tools and improved cancer treatment.' under Sixth Framework.

assistant: **Concept**

The TRANSFOG project aims at the systematic identification and functional characterization of novel cancer genes with high potential diagnostic and therapeutic value. The TRANSFOG Partners will bring together world recognised competences and resources to reach the following, integrated research objectives: 1) identification of novel candidate cancer genes through cancer-oriented genomic screenings, using tumour tissues as well as cellular and animal models, to generate a prioritized panel of genes involved in breast, colon and lung cancer progression and metastasis; 2) Full-length cDNA collection of the identified candidates, and setup of systems for high-throughput in vitro and in vivo gene delivery; 3) Collection of retroviral expression plasmids encoding small interfering RNAs, for systematic downregulation of candidate genes; 4) identification of new molecular targets for cancer therapy, which will involve adaptation of existing cell-based and model organisms assays to a high throughput configuration, for systematic analysis of gene gain- and loss-of function of the identified candidate genes, using vectors developed under Activities 2 and 3, and selection of genes for preclinical, proof-of concept validation of novel therapeutic targets; 5) Proteomic analysis of signal transduction and protein-protein interaction; focussed on the candidate cancer genes; this will allow better dissection of aberrant cancer signalling pathways. 6)Validation of the diagnostic potential of the identified cancer genes, towards the clinical use of diagnostic molecular signatures; 7) Generation of a shared informatic platform for data handling and gene functional annotation. This will greatly increase Europe competitiveness, provide a huge structuring effect on the ERA in the field of fun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'OpenCarData'.

assistant: **Innovation**

Vehicle Emission Profiles leverage OpenCarData / OBD-II Technology to generate real-world carbon emission profiles from passenger vehicles to contrast these with European Union legislation for Car Energy Labelling (Directive 1999/94/EC).Emission Profiles have a one-to-one relationship with a driver's automotive behaviour, hence they provide a management tool for drivers, fleet owners & governments to share, compare & change real world – location based – car related CO2 emissions.