RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Thinking rough towards sustainability' under Horizon 2020.

assistant: **Concept**

To tackle its critical raw material (CRM) dependency, Europe needs comprehensive strategies based on sustainable primary mining, recovery from secondary resources and recycling. The EC classified 20 CRMs due to their high economic importance and high risk of supply interruption. e.THROUGH has the ambitious vision of turning the challenge of CRMs dependence into a strategic strength for Europe, contributing towards declassifying some CRMs, as tungsten, indium, gallium and chromium, by: 1) Promoting new trends in the characterization and exploration of mineral deposits; 2) Mapping CRMs between EU mining regions; 3) Gaining knowledge on innovative processes for recovery secondary CRMs; 4) Redesign construction materials using secondary materials, closing loops, strongly supporting waste minimization; 5) Life Cycle Assessment (LCA) for the evaluation of global environmental impacts; 6) Transferring newly generated knowledge to stakeholders, both for policy development and standardization, and for shaping responsible behaviours. e.THROUGH is an intersectoral and interdisciplinary consortium of EU & Third Country partners of leading institutions that see waste as a resource to recover CRMs, influencing the whole value chain. By training human resources in CRMs´value chain, their recovery, recycling, further reuse and LCA, they become the much needed young and senior scientists and engineers for the growing EU CRM industry. The consortium comprises 40% industry and 60% research partners. This should help push Europe to the forefront in CRM sectors, providing eco-friendly alternatives in supply. The generated scientific relevant knowledge will be transferred to shape industries, communities and individual citizens’ behaviour, fostering corporate sustainability performance, impo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Development of a Chimpanzee Adenovirus Type 3 Ebolavirus Zaire Vaccine'.

assistant: **Objectives**

The first Ebolavirus Zaire (EBOV) outbreak of 2014 was declared on 22 March in Guinea. As of 30 September 2014, the World Health Organization (WHO) reports the total number of cases in the current outbreak of Ebola virus disease (EVD) in West Africa at 7470, with 3431 deaths. The US Centers for Disease Control and Prevention states that the number of cases is currently doubling every 20 days and estimates the true number of cases at 2.5 times higher than that reported.  Countries that have been affected are Guinea, Liberia, Nigeria, Senegal and Sierra Leone. Ten percent of fatalities have occurred among front line health care workers attempting to contain the epidemic. On 7 August 2014, the WHO requested that GSK “fully engage in WHO-coordinated efforts to test, license and make available safe and effective Ebola interventions” to assist in the control of the outbreak.Taking into account the early stage of development, EbolaVac seeks to accelerate the clinical development of the GSK chimpanzee adenovirus type 3 Ebolavirus Zaire (ChAd3-EBO Z) vaccine candidate to make the vaccine available to frontline health care workers at risk and to be used in the containment of EBOV outbreaks.The project specifically aims to: (i) complete Phase 1 development of the ChAd3-EBO Z vaccine by supporting a clinical study conducted in Lausanne, Switzerland (WP2); (ii) evaluate the ChAd3-EBO Z vaccine in Phase 2 testing on adults and children at established clinical study centers in West Africa outside the current most heavily affected countries of Guinea, Sierra Leone, and Liberia (WP3);  (iii) investigate immunological effects of vaccination and the effect of booster vaccination (WP4) and (iv) centrally manage and analyse clinical study data (WP5).Besides using an innovative vaccine techn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'LAUNDRY Application Using RFID tags for Enhanced Logistics' to be submitted under Fifth Framework.

assistant: **Abstract**

LAUREL aims at developing a RF ID tag system with multi-read capability and very small read/write RF tags. LAUREL will achieve a never reached cost/performance level. Computer simulation will be used to optimise RF system design, to predict reading performance, support compliance with RF regulations and facilitate adaptation of LAUREL to various applications. LAUREL targets industrial mass-market applications. Tag packaging, antenna and chip embedding will be designed to meet the needs of mass-production of very low-cost items of 100s of million units per year. The LAUREL tag technology will be validated in a linen identification and tracking system for the laundry industry. It will be generic and adaptable to other application needs e.g. supply chains, courier/parcel delivery, medical applications. The consortium includes a leading tag manufacturer, a research institute, a system integrator and an end-user.Objectives:LAUREL aims at developing an RF ID tag system with multi-read capability and very small RF tags with read/write memory while achieving a never reached cost / performance level. LAUREL targets industrial mass-market applications which have clearly identified immediate needs and for which cost benefit can be reached rapidly. The tag packaging, antenna and chip embedding, will be designed to meet the needs for mass-production of low-cost items of 100s of million units per year. Successful introduction of LAUREL in the laundry industry will provide the critical mass required to cut tag production cost and facilitate penetration into other markets. Computer simulation will be used to optimise RF system design, to predict reading performance and support compliance with international RF regulations. The LAUREL tag technology will be validated as a part of a linen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Targeting Rab27A with covalent inhibitors for the treatment of metastatic breast cancer' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Invasion and metastases remain to date the major causes of cancer mortality around the world. Rab27A is a small GTPase that regulates vesicles trafficking and is involved in many physiological processes, e.g. melanosome transport. Being a small GTPase, Rab27A acts as a molecular switch that cycles between an inactive state (GDP bound) and an active state (GTP bound), in which this protein is able to bind to specific effectors to trigger signalling cascades in cells. Current studies suggest a role for Rab27A in exosome-mediated pre-metastatic niche promotion. Hence, interfering with Rab27A PPIs could be effective in reducing and preventing the occurrence of metastasis in cancer. Small GTPases are renowned as challenging targets and have been long considered undruggable, but the unique presence of two non-conserved cysteines in Rab27A offers a perfect starting point for the development of selective covalent inhibitors. These residues are located in the proximity of a major interaction site with a known effector of Rab27A, Slp2, therefore encouraging for targeting PPIs. A screen of covalent fragments based on the recently developed quantitative Irreversible Tethering (qIT) assay has led to the discovery of novel hits with enhanced reactivity for Rab27A against glutathione. The current project aims to (i) obtain potent Rab27A covalent inhibitors by growing hit fragments, and (ii) demonstrate selective Rab27A target engagement in cells, and efficient disruption of the PPIs of Rab27A with its main effectors. Collaboration with the CRUK Beatson Institute will provide direct access to in vivo models to validate the contribution of Rab27A to metastatic development in cancer by use of such chemical probes, whilst state-of-the-art covalent fragment know-how will be accessed for co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Clonal Deletion versus Clonal Diversion: Footprints of Self-Tolerance in the T Cell Repertoire' (2014-2020).

assistant: **Concept**

Self-tolerance is a key feature of the immune system; its failure causes autoimmune diseases such as Multiple Sclerosis or Type-1-Diabetes. Remarkably, T cell tolerance operates via two fundamentally different mechanisms: potentially dangerous cells are either eliminated (clonal deletion) or re-programmed to differentiate into regulatory T (Treg) cells (clonal diversion). Paradoxically, both tolerance modes can ensue from self-antigen-encounter in the thymus, and the parameters specifying these opposing cell-fates remain poorly understood. Moreover, the relative contribution of clonal deletion versus clonal diversion to tolerance at the level of diverse immune cell repertoires has not been determined. In particular, the paucity of antigen-specific cells is a major experimental obstacle to unravelling to what extent cells with shared autoreactive specificity, yet different T cell receptors (TCRs), are subject to either mode of tolerance.Breakthroughs in visualizing minute cohorts of antigen-specific cells, characterizing the TCRs on individual cells and large-scale TCR sequencing now provide a unique opportunity to tackle these challenging questions. Based upon my expertise in thymus biology and T cell selection, I will exploit these technological advances to reveal where and how tolerance either generates ‘holes’ in the repertoire or diverts cells into a ‘benign’ sub-repertoire. The main objectives are (i) to identify and classify deleted or diverted TCR-entities through comparing ‘uncensored’ and ‘censored’ repertoires in the absence or presence of a disease-relevant autoantigen and (ii) to identify TCR intrinsic features as well as T cell extrinsic determinants that specify clonal deletion versus clonal diversion.The proposed research elucidates a fundamental aspect o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Novel characterization of crop wild relative and landrace resources as a basis for improved crop breeding'.

assistant: **Concept**

The goal of agrobiodiversity conservation, unlike other forms of conservation, is not only the conservation of species and intra-specific genetic diversity related to agriculture, but also to promote its sustainable use in facilitating agricultural production. Although significant progress has been made in the conservation and management of plant genetic resources for food and agriculture (PGRFA) globally and in Europe, there remain two critical areas where progress has been limited: (a) the use of conserved agrobiodiversity by breeders and (b) the systematic conservation of crop wild relative (CWR) and landrace (LR) diversity. Specifically for breeders and CWR / LR diversity conservationists, the status quo is no longer an option as human-induced climate change is threatening the maintenance of the very diversity breeders require to mitigate the adverse impact of climate change. Conventionally, breeders have used their own lines and stocks to generate novel crop varieties, but these materials are relatively genetically uniform and it is now increased recognition that CWR and LR offer the breadth of genetic diversity required by breeders to meet the novel challenges of climate change and rapidly changing consumer demands. Therefore, the aim of PGR Secure is to research novel characterization techniques and conservation strategies for European crop wild relative and landrace diversity, and further, to enhance crop improvement by breeders, as a means of underpinning European food security in the face of climate change.  To achieve these goals PGR Secure has four research themes:  1. Investigation of novel characterization techniques, including: (1a) Genomics, phenotyping and metabolomics, (1b) Transcriptomics, (1c) Focused Identification of Germplasm Strategy; 2. CWR and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Distributed Intelligence and Technology for Traffic and Mobility Management' (DIT4TraM).

assistant: **Innovation**

The transport sector is expected to alter shape in the coming decades. This transition is driven by user-centred mobility services, integrated and intelligent transport networks, pricing and payments, automation, safety and security, as well as public and private innovation. Next to Big Data and Artificial Intelligence, these developments provide major opportunities, but also increase system complexity. The overarching aim of DIT4TraM is to develop, implement and test a generic distributed control paradigm, applicable at the level of traffic operations, mobility management, demand-supply synchronisation and shared mobility, including advanced monitoring, estimation and (machine learning) forecasting technology, and associated algorithms for a variety of novel multi-modal management and mobility concepts operating at all urban scales. A holistic approach to decentralisation, distribution and mechanism design for monitoring and control is proposed aiming to achieve social optimality, yet with only necessary information exchanges, which is further translated into four key application fields corresponding to four interlaced urban scales carefully selected to ensure that all relevant challenges are tackled. Pilots in several cities across Europe are organised to test DIT4TraM concepts and assess market potential and design business models. Our vision is to support the transition to seamless and sustainable connected and autonomous mobility by disentangling the system components to the highest extent possible, yet ensuring sufficient cooperation and emergent coordination by smart system design, leading to liveability, safety, resilience, efficiency, as well as privacy, participation, fairness and sustainability on a city scale. The DIT4TraM partnership (4 Universities, 5 Indu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Locked between formulas: creativity in oral and transitional  poetic texts' in the context of a Horizon 2020 call.

assistant: **Objectives**

The human mind is capable of creativity and innovation unparalleled by any other species. At the same time, human beings elaborate and preserve complex and highly-stable traditions, transmitting them over very long time spans by means of the spoken word and through a variety of technologies, such as writing. How does human cognition give rise to such complex manifestations as oral poetic performance, and how are they affected by the introduction of writing? ORFORCREA investigates the cognitive basis of creativity in verbal art, examining its interplay with both oral tradition and literacy.How can we approach as intricate a problem as verbal creativity with manageable, but at the same time ecologically valid and culturally situated data? While everyday human speech is extremely complex for analysis and has vast lexical and phraseological resources, the language material in oral traditions is typically organized in narrower terms, with idiomaticity enhanced because of poetic requirements, such as the constraints of the poetic line, rhyme patterns, plots, or themes, as well as form-meaning normativity (validity of a given expression within its poetic tradition). The cognitive study of phrasal and grammatical structures in oral poetic traditions is thus comparable to working in a ‘natural’ lab, where the linguistic material, selected throughout long diachronies and innumerable performances, ideally fits the purpose of examining the creative use of formulaic resources. Thus ORFORCREA targets the essential feature of oral poetic traditions, idiomaticity, seeking to produce insights about the formulaic nature of language in general
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of point of care systems for clinical diagnostics' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Research into new quantitative diagnostic Point of Care (POC) systems using Immunoassay technology with different detection techniques. POC tests can be used I. e. during operations or at the place of accidents to make a quick and accurate diagnosis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Centrality Analysis in Research Networks' under Seventh Framework.

assistant: **Concept**

Tables and graphs measuring cross-national integration and interconnectivity of  research actors and systems in Europe are appropriate tools to monitor progress on ERA and to support the policy discussions. The indicators work carried out in this project will exploit data on transnational integration available from the European research framework programmes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Linking the diversity of Type Ia supernovae to their progenitor systems' in the context of a Seventh Framework call.

assistant: **Objectives**

A detailed understanding of the progenitors and explosion physics of Type Ia supernovae (SNe Ia) remains a missing link in their use as cosmological probes. This project aims to address two of the fundamental questions that exist about SNe Ia; is there more than one way to make a SN Ia and how does their observed diversity depends on their progenitor systems and host galaxy environments? ESO will play a key role in my project; their expertise, both technical and scientific, will be instrumental in its success. ESO will provide me with many new opportunities to expand my skill set, essential for the development of my research career. I will use SN Ia spectral data to discriminate between potential progenitor scenarios by studying absorption lines from circumstellar material (CSM). Recent studies of CSM have linked SNe Ia in spiral galaxies to the single-degenerate progenitor scenario, but did not study SNe Ia in elliptical galaxies. I will expand this study to elliptical galaxies to determine if the progenitor systems of SNe Ia in young and old stellar populations differ. SNe Ia also display surprising observational diversity that correlates with the properties of their host galaxies. Evidence is mounting towards the possibility that there may be multiple progenitor channels for SNe Ia, and that metallicity may play a fundamental role. Recently, I identified an evolution with redshift in the spectra of SNe Ia, which is consistent with decreasing metallicity with increasing redshift. I will investigate how the spectral and photometric diversity of a large, unbiased sample of low-redshift SNe Ia Ia relate to their host galaxy properties. If the diversity of SNe Ia properties (and hence their progenitor systems) is confirmed to depend on host galaxy metallicity, then this w