RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Multi-layer biopolymer films demonstrating selective gas barrier and functional properties suitable for high performance food packaging, derived from integrated bio-refining of sustainable biomass'.

assistant: **Innovation**

Conventional biorefineries target production of a single product stream utilising a dedicated crop based feedstock. Such processes offer limited commercial viability, generate significant waste streams and raise ethical and sustainability concerns with regards to the feedstocks used (competition with food crops & genetic modification to improve yield). Paralleling conventional petroleum refineries, integrated biorefining overcomes these limitations through utilisation of the wider biomass components to deriving multiple bulk and high value product streams (zero waste processes), thereby achieving commercial competitiveness in line with conventional refineries and enabling a transition from dedicated non-food crops to low cost, readily available and sustainable biomass. The Phytatec Technology Platform is built on this concept, combining environmentally benign critical fluid processes with the selectivity and efficiency of enzyme transformations.The BREW-PACK project will apply and further develop the existing Phytatec platform for the integrated biorefining of brewers spent grain ‘BSG’ (a readily available and low cost biomass feedstock), building on two core areas of innovation:- Application and further development of existing critical fluid processes for the sequential hydrolysis and fractionation of BSG to lipophilic, proteinaceous and polar (carbohydrate rich) primary material fractions- New know-how, strategies and technological development for the separation and knowledge based transformation of BSG proteins, enabling development of multi-layer biopolymer films demonstrating enhanced performance and functionality suitable for innovative high value packaging applicationsThe project will conclude with a desk based feasibility study for design of a pilot and subseque
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Dopaminergic Neurons for Cell Therapy in Parkinson's Disease'.

assistant: **Concept**

Replacement of lost dopaminergic neurons by neural transplantation with embryonic nigral tissue is a most promising approach to the treatment of Parkinson’s disease. However, the limited availability of human embryonic dopaminergic neurons makes the search for alternative sources of transplantable neurons a priority. Based on an existing collaboration, a French academic research group with expertise in neurobiology and brain disease and a German company specialized in cell isolation and molecular gene analyses united to investigate the regulation of dopaminergic diffentiation and to develop new tools for the purification of dopaminergic neurons.We will analyze the molecular regulation of neuronal, in particular dopaminergic, diffentiation of new neurons that are permanently generated in the adult mammalian brain. To do so we will use sophisticated cell isolation strategies in concert with analysis of minute amounts of nucleic acids to observe changes in gene, transcript and protein expression in time and space. We will functionally test identified factors using in vivo assays and generate new tools for the isolation of neuronal subpopulationsWe will improve already known and develop new approaches that allow the efficient and reliable purification of dopaminergic neurons at different points of maturation from cultured stem cells. Furthermore, we will use known and identify new surface markers of neural progenitor cells and pluripotent cells to generate positive and negative cell sorting methods that will lead to transplantable cells in the absence of contaminating pluripotent and proliferative cell types. We will demonstrate the efficiency of these positive and negative selection approaches via transplantation experiments in vivo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

We concur to the IMI on “Reclassification of SLE, connective tissue diseases and RA” call by presenting a proposal aimed at using the power of OMICs, and bioinformatics to identify new classifications for diseases known to share common pathophysiological mechanisms. Such knowledge has not been applied to individual patients, depriving them from potential benefits in terms of the use of new therapeutic agents that are being developed for one disease but cannot be applied in another due to current clinical classifications. We will investigate individuals with systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjögren’s syndrome (Sjs), rheumatoid arthritis (RA), primary antiphospholipid syndrome (PAPS) and mixed connective tissue disease (MCTD), jointly as systemic autoimmune diseases (SADs). We believe that there will be overlapping clusters of individuals across diseases that will share molecular features. To determine these clusters we will, study 2000 cases of SADs, and 600 healthy controls to identify molecular clusters and their cellular and clinical correlates. In addition, we will study kidney and skin biopsies to define the development of molecular markers with severe kidney disease or with skin fibrosis. In this way we will define systemic and tissue taxonomies. We will study complete as well as isolated peripheral blood mononuclear cells and subpopulations and in biopsies gene expression and epigenetic marks with a combination of array and next generation sequencing (NGS) strategies. These studies will define cellular counts and proportions and changes in gene expression related to specific cellular populations. We will also use NGS strategies to define the presence of risk alleles (HLA and non-HLA) in all individuals. The data will be complemented wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Early screening of eye diseases using automated diagnosis of high-fidelity 3D images' (EASED3D) under Horizon 2020.

assistant: **Objectives**

Europe has an ageing demographic, 25% of the population over 40 years old suffer from eye disesase. As an example, 5% of the diagnosed disease are categorised as Age-related Macular Degeneration (hereafter AMD). This disease can be treated, if diagnosed early.The problem:A number of severe diseases, such as AMD, can be diagnosed by scanning and analyzing the retina, however due to microscopic movement of the eye, only a small part of the retina can be “photographed” as the current technology is too slow to capture a clear image. The method used to diagnose eye diseases is called “Optical Coherence Tomography” (hereafter OCT)  2D imaging, and is usually performed by specialised eye doctors (ophthalmologists). To enable earlier diagnosis,  screening for eye diseases such as AMD are increasingly being done by opticians, but due to the complexity of the eye, and the quality of the 2D images, this leads to many false-positives. Despite the clear benefit of earlier screening, the many false-positive resulys found by opticians are a burden on ophthalmologist and are taking up time and resources.The solution:OCTLIGHT has developed a patented specialized light source module, that enables OCT “eye scanner” devices to scan the eye 10x faster than the technology presently used, giving them the ablity to do clear wide field 3D image scans of the eye.The wide field 3D images make it easier for ophthalmologists to detect eye diseases, but just as significant, the high quality of the data (image) allows for the use of Machine Learning  for diagnosing eye diseases.  This means that OCTLIGHTs technology enables better screening, which can be combined with Machine Learning to enable better and more reliable diagnosis even if performed by opticians. This should reduce the many false-positi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Abstractions for Safe and Secure HW-SW Systems'.

assistant: **Concept**

Trains, planes, and other safety- and security-critical systems that our society relies on are controlled by computer systems, as is much of our critical infrastructure, including the power grid and cellular networks. But can we trust in the safety and security of these systems?The starting point of SafeSecS is the observation that todays hardware-software abstractions, instruction set architectures (ISAs), are fundamentally inadequate for the development of safe or secure systems. Indeed, ISAs abstract from timing, making it impossible to develop safety-critical systems that have to satisfy real-time constraints on top of them. Neither do ISAs provide sufficient security guarantees, making it impossible to develop secure systems on top of them. As a consequence, engineers are forced to rely on brittle timing and security models that are proven wrong time and again, as evidenced e.g. by the recent Spectre attacks; putting our society at risk.SafeSecS will attack the problem at its root by introducing a framework centered around hardware-software contracts that extend the guarantees provided by ISAs to capture key non-functional properties. Hardware-software contracts formally capture the expectations on correct hardware implementations and they lay the foundation for achieving safety and security guarantees as the software level. Below the hardware-software interface, SafeSecS will contribute modular design principles and tools to construct microarchitectures that provably satisfy a given hardware-software contract. Above the hardware-software interface, SafeSecS will develop rigorous, precise, and scalable techniques to guarantee key safety and security properties at the software level on top of hardware-software contracts. As a whole, SafeSecS will enable the systemat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development and differentiation of CD8 T lymphocytes'.

assistant: **Innovation**

CD8 T lymphocytes have a fundamental role in ensuring the control of different types of intracellular pathogens including bacteria, parasites and most viruses. This control may fail due to several reasons. The current aggressive anti-cancer therapies (or rarely certain congenital immune deficiencies) induce CD8 depletion. After bone-marrow transplantation, long time periods are required to ensure T cell reconstitution particularly in the adult. This long lag-time is due to the long-time periods required for hematopoietic precursors to generate T lymphocytes and to a thymus insufficiency in the adult. However, even when CD8 T cells are present CD8 immune responses are not always adequate. Certain chronic infections, as HIV, induce CD8 dysfunction and it is yet unclear how to generate efficient CD8 memory responses conferring adequate protection. To address these questions this project aims 1) To find strategies ensuring the rapid reconstitution of the peripheral and the gut CD8 T cell compartments a) by studying the mechanisms involved HSC division and T cell commitment; b) by isolating and characterizing progenitors we previously described that are T cell committed and able of an accelerated CD8 reconstitution c) by developing new strategies that may allow stable thymus transplantation and continuous thymus T cell generation. 2) To determine the mechanics associated to efficient CD8 memory generation a) by evaluating cellular modifications that ensure the efficient division and the remarkable accumulation and survival of CD8 T cells during the adequate immune responses as compared to inefficient responses b) by studying CD8 differentiation into effector and memory cells in both conditions. These studies will use original experiment mouse models we develop in the laborat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Chickpea as a potential source of high-quality protein for food formulas' in the context of a Fifth Framework call.

assistant: **Objectives**

Plants provide essential elements (protein, photochemical) nutritionally healthy. Actually soybean is the most commonly used protein of plant for oil pressing, as protein for infant food formulas and meat substitutes for vegetarians. Problems are linked to soybean : dependence of European economy from USA exportation, increasing prevalence of alergenicity to its protein, apparition forgo Soya. Then, there is a need to explore another protein source for foods. The nutritional and functional properties of chickpea suggest that its elements have a high potential for use in foodstuff. Until now its potentialities have not been really studied. The aims of the project are- to develop novel chickpea types with a wide micronutrient spectrum (to suit a range of end products and direct uses),- to design and develop technical processes to prepare improved chickpea protein and photochemical products under pilot plant and factory conditions. It is expected to develop a new source of protein with low allergen city and high quality, a new source of non-nutritional factors and provide essential minerals and vitamins to create new foodstuff with improved nutritional value.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Validating Changes and Upgrades in Networked Software' (PINCETTE), addressing dissemination and exploitation.

assistant: **Impact**

Europe relies on the availability and flawless functioning of distributed infrastructures, such as electricity, water, communication, transportation, and environmental management. This infrastructure is based on distributed networked IT systems for monitoring and control.<br/>Technological innovation offers opportunities for more efficient infrastructure.Innovation in infrastructures and the resulting improvement in quality of life are hindered by the danger of upgrades:\tin a new version, some of the existing functionality can be lost;\tincompatibilities between the old and new version can result in major service outages;As it is infeasible to update the entire infrastructure at once, periods of coexistence between old and new components are inevitable.<br/>As a result, infrastructure upgrades are done only once the existing infrastructure performs below acceptable levels.  Lowering the risk of infrastructure updates will benefit society, infrastructure operators, and the European systems vendors. All existing validation solutions do not take upgrades into account. A solution for validating upgrades is in dire need because of shorter product lifecycles and increasing complexity and scale of networked systems.<br/>PINCETTE will develop the technology to ensure safe infrastructure upgrades by validating continuously evolving networked software systems.PINCETTE will 1) reduce the cost and time to market of upgrades by several orders of magnitude; 2) increase the level of confidence in the safety of upgrades; 3) enable certification of upgrades.<br/>The PINCETTE consortium is composed of the leading European research experts and prominent infrastructure providers. The PINCETTE technology will be validated at:\tABB produces and sells components and systems used in utilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European animal disease genomics network of excellence for animal health and food safety' under Sixth Framework.

assistant: **Concept**

The production of high quality safe food, respecting animal welfare and the environment, is the primary objective of European livestock and aquaculture industries. Particular focus will be placed on the improvement of animal health. Genomic tools elucidati ng host-pathogen interactions offer new opportunities to devise sustainable solutions to existing and arising problems, through novel diagnostic, intervention, breeding and husbandry strategies. However, relevant genomics research is fragmented and the res tructuring of the European research capacity is required to create the scale and breadth of competencies needed to realise these opportunities. Hence, a Network of Excellence (106 researchers, 46 PhD, 13 partners, 10 countries) in the genomics of host-path ogen interactions in animals is proposed to bring together sufficient excellence and resources to make a real difference to animal and human health, and improve the quality of animal products. Integrating activities will ensure that all partners have easy and durable access to the best available facilities, biological resources, technological platforms, software, analytical tools and knowledge. The Joint research programme will ensure that this integration results in high quality research that is directed t owards the most pressing issues, and presents the best opportunities to address European concerns. Activities to spread excellence will maximise technology transfer, communication with other scientific groups and society as a whole, whilst addressing ethic al and consumer concerns. Staff training and enhanced mobility are key aspects to success. EADGENE will be bound together by a strong and sustainable management structure. EADGENE will: create a durable virtual European laboratory in genomics of host-patho ge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Spatially resolved subsurface characterization of semiconductor wafers by high resolution x-ray diffraction'.

assistant: **Objectives**

The main knowledge and technology to be transferred is the applicant's experience in characterization of grown-in and process-induced defects and stresses in semiconductors by means of X-ray diffraction techniques and his potential to contribute significantly to the research of surface damage depth profiling and lateral mapping after wafer surface preparation. His multiple beam diffracting technique can be useful base for the development of new techniques related to subsurface damage profiling and characterization and understanding of stresses and defects generation and treatment in semiconductor wafers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mycelium-based substrate for sustainable flexible PCBs' (MycoSub) under Horizon Europe.

assistant: **Objectives**

Printed circuit boards are an indispensable technology present in all classes of modern electronics. Their flexible embodiments (flexPCBs) enable current and emerging form factors and drive the transition to human-centered applications. At the same time, PCBs are notoriously difficult to recycle and contribute majorly to the growth of electronic waste and an unsustainable use of resources. A paradigm change towards bioderived and biodegradable materials promises a remedy, however so far, no viable solution for sustainable (flex)PCBs exists.  MycoSub takes on an entirely new approach of growing and refining fungal mycelium skins as environmentally friendly and entirely biodegradable, yet high performance substrate material for the manufacturing of flexPCBs. Building upon MycelioTronics, the first mycelium-based electronic circuits, we here aim at developing an industry-compatible process flow that seamlessly merges into established commercial procedures for rapid adoption of the technology. With facile post-processing steps that do not impede biodegradability, we will achieve a competitive flexible circuit board substrate with high thermal stability, high flexibility and low surface roughness. We aim to develop both conventional subtractive (etching) as well as fully sustainable additive manufacturing techniques for low-conductivity, soldering-compatible conducting traces. Such MycoSub-flexPCBs will ultimately provide unprecedented levels of sustainability through the combination of a biodegradable yet resilient substrate with efficient waste-minimizing, energy-saving workflows and re-use strategies for precious metals and electronic components. These endeavors will be accompanied by thorough material characterization, ensuring that MycoSub materials live up to the high