RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'GREen ENdeavor in Art ResToration', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

European Cultural Heritage (CH) is a crucial resource that must be maintained, preserved and accessible, to counteract degradation enhanced by unfavorable environmental conditions and climate changes. Conservation methodologies lack durability, sustainability and cost-effectiveness, and are typically based on energy-consuming processes or non-environmentally friendly materials.  Coping with these issues, GREENART proposes new solutions based on green and sustainable materials and methods, to preserve, conserve and restore CH: 1) Protective coatings based on green materials from waste and plant proteins, with self-healing and reversibility character, possibly functionalized with organic/inorganic nanoparticles to impart VOC capture, anti-corrosion and barrier behaviors. 2) Foams and packaging materials made by biodegradable/compostable polymers from renewable sources (polyurethanes and natural fibers) to control T/RH. 3) Consolidants based on natural polymers from renewable sources, to mechanically strengthen weak artifacts. 4) Gels and cleaning fluids inspired by the most advanced systems currently available to conservators, improving them according to green and circular economy. 5) Green tech solutions for monitoring CH assets non-invasively against pollutants and environmental oscillations. Life cycle Assessment and modeling will favor the “safe-by-design” creation of affordable solutions safe to craftspeople, operators and the environment, and minimize energy-consumption in monitoring museum environments. Such holistic approach is granted in GREENART by a multidisciplinary partnership that gathers hard and soft sciences and engineering, including academic centers, innovative industries and SMEs, conservation institutions and professionals, museums whose collections h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fundamental investigations of high-resolution LA-ICPMS: Fast Imaging – Resolution, Sensitivity, and Time (FIRST)' in the context of a Seventh Framework call.

assistant: **Objectives**

Laser ablation–inductively coupled plasma mass spectrometry (LA–ICPMS) is a robust, sensitive, and wide-dynamic-range micro-analytical technique for the spatially resolved determination of elemental composition. In LA–ICPMS, a pulsed laser beam removes (ablates) minute quantities of solid sample, which are transferred online to an ICPMS for elemental and/or isotopic analysis. When combined with precise sample positioning, LA–ICPMS can generate two- or even three-dimensional maps of element-abundance maps across a sample surface. However, conventional ICPMS instruments only measure ions of one mass-to-charge value (m/z) and, in combination with the transient nature of LA signals, this limits the precision and accuracy of multi-elemental LA-ICPMS.  Additionally, commercial LA cells are designed to distribute the ablated analyte over a period of several seconds to deliver pseudo steady-state analytical signals; these long residence times increase measurement time and limit spatial resolution. In this project, I will combine recently developed fast-washout LA-cell technology with a new ICP–time-of-flight mass spectrometer (ICP–TOFMS) developed in the Günther lab at ETH Zurich. The LA cell temporally compresses and concentrates ablated aerosol into a narrow plug, which improves signal-to-noise ratio, and delivers it into the ICP–TOFMS for rapid simultaneous and complete elemental mass-spectrum generation (1 spectrum every 33 µs). Fast-flow LA–ICP–TOFMS overcomes the limitations of sequential-acquisition MS approaches, and can be used to produce high-resolution elemental images with measurement speeds two orders of magnitude faster than conventional systems. Current ICP–TOFMS sensitivities should allow trace-element mapping with resolution approaching one micrometer; this res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Geomar' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Description:GEOMAR, the Research Center for Marine Geosciences of Kiel University(CAU) pursues basic environmental research in the broadest sense. GEOMAR is composed of four scientific divisions (Marine Geodynamics, Volcanology and Petrology, Paleoceanology, and Marine Environmental Geology). The scientific divisions of GEOMAR are characterized by their global perspective, by the multitude of scientific problems, and by the attempt to reach an integrated understanding of the marine geoprocesses. The Marine Geodynamics Department of GEOMAR, Kiel, Germany focuses research on tectonic processes shaping the Earth's crust and upper mantle. Most research is accomplished using seismic data, which offer the best resolution of subsurface structure. We offer access to state-of-the-art marine seismic reflection data processing software operated on a network of more than 20 workstations. GEOMAR computer facilities are by their size, functionality, and sophistication unique in the European academic community, as no one has such devoted software for analysis and processing of seismic data. Also, we offer access to our Ocean Bottom Hydrophones and Seismometers (OBH/S). The GEOMAR OBH/S has received a worldwide recognition since it has been put into service because of its reliability, data capacity, and cost effectiveness. The system currently consists of 30 instruments, two data recovery and transcription systems, and workstations equipped with the necessary software and peripherals for onboard processing. Visiting scientist will be guided by experienced personnel through the different seismic data processing steps and also onboard research vessels during OBH/S data acquisition.Applications can be send at any time, and user selection will be made approximately twice per year. We there
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Nonlinear Mechanisms of Spatial Symmetry Breaking in Living Systems'.

assistant: **Innovation**

The study of experimental pattern formation mechanisms and its relevance to biology has been restricted to nonlinear chemical systems that produce spatial Turing patterns (CDIMA reaction), spiral waves (BZ reaction), propagating fronts and pulses (GO reaction). The important differences between these artificial systems and the natural spatial differentiation occurring in living cells do not allow for direct application of nonlinear dynamics tools to analyze biological patterns. The complexity of living organisms is also complicating the understanding of the underlying mechanisms for the arising of living patterns, therefore a much simpler symmetry breaking mechanism in living cells will allow a closer connection between developmental biologists and nonlinear physicists. The implementation of a spontaneous symmetry breaking mechanism in tissue culture mammalian cells using engineered cell-to-cell communication will constitute a highly improved model system for morphogenesis, early embryo development and skin patterning. This mechanism will be implemented using a highly interdisciplinary approach combining experimental /theoretical experience in chemical symmetry breaking systems and nonlinear physics tools together with a background in synthetic biology and signaling pathways. The candidate background in pattern formation, biophysics and cell biology combined with the expertise of the host laboratory (Elisa Martí at the Parc Cientific of Barcelona University) in symmetry breaking during early development constitute the perfect complement to carry out this type of research. An in-vitro pattern formation system will change the way biologists and physicists interact to understand the complexity of self-organization in living organisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Principles of endogenous and therapeutic mRNA turnover in vivo' (ViveRNA).

assistant: **Innovation**

During the COVID-19 pandemic, we witnessed the application of mRNA vaccines for SARS-CoV-2, paving the way for the widespread use During the COVID-19 pandemic, we witnessed the application of mRNA vaccines for SARS-CoV-2, paving the way for the widespread use of therapeutic mRNAs in medicine. However, lack of knowledge regarding mRNA metabolism in vivo limits the optimization and refinement of such therapies. Our preliminary data, acquired via Direct RNA Sequencing (DRS), shows that variability of poly(A) tail length and, therefore, stability of endogenous and therapeutic mRNAs in different tissues and cell types is much larger than previously thought. Here, we propose the ViveRNA project, which will enhance the DRS (eDRS) pipeline and combine it with analyses of mouse models, primary cell cultures, and synthetic biology approaches to examine the nature of mRNA turnover in vivo and characterize the metabolism of endogenous and administered mRNAs. The goal of the ViveRNA project is to elucidate the complexity of mRNA lifetime regulation. Specifically, our aims are:•Part 1: Construction of an enhanced nanopore Direct RNA Sequencing pipeline (eDRS) for comprehensive analyses of mRNA metabolism. eDRS will assess the composition and lengths of poly(A) tails, modifications, isoforms, and dynamics.•Part 2: Comprehensive analysis of the lifecycle of endogenous mRNAs, analyzing: dynamics, ribosome association, and poly(A) tail metabolism in organs and primary cells and providing insights into the role of particular enzymes. The reach data resource will help designing better mRNA therapeutics and enable the formulation of testable mechanistic hypotheses.•Part 3: Description of the metabolism of therapeutic mRNAs in relevant cell types and tissues. Then, together with the knowledg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Female employment and family formation in national institutional contexts'.

assistant: **Concept**

The aim of this project, in the general framework of Task 1: social and economic challenges of changing family structures, and more specifically the work/education/family relations, is both:- to improve the scientific knowledge of the relations inside and between the two dynamics respectively of family formation and female professional life cycle,- to contribute to the European employment strategy in terms of employability and adaptability of the female work force in congruence to the equal opportunity policy.The research will be strongly based on the mobilisation of Eurostat data bases and comparative in nature.It will focus on the role of the institutions in the explanation of the differences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Molecular divergence in a marine animal-microbial symbiosis since the closure of the Isthmus of Panamá' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Recently it has become clear that host-associated microbes play a major role in host adaptive responses to environmental change. To predict future responses, we can explore the past and use geological events, which provide valuable insights into adaptive mechanisms because these events were major drivers of evolution. The formation of the Isthmus of Panamá separated a previous, ancient ocean and all of its marine life into the Pacific Ocean and the Caribbean Sea. These two oceans have developed into very different habitats. Closely related animal populations that were separated by the Isthmus had to adapt to diverging environmental conditions. Today we find closely related species pairs, i.e., geminate species, that are genetically very similar but live in highly divergent habitats. This provides a powerful study system to explore drivers and processes of speciation, diversification, and adaptation. In this project, I am integrating this knowledge to study the evolution of an animal-microbial symbiosis that was divided into several geminate species pairs by the Isthmus of Panamá. I am going to compare lucinid clam populations (Lucinidae) and their endosymbiotic bacterial chemosymbionts (Candidatus Thiodiazotropha) at the genomic and transcriptomic level. Lucinid clams are an excellent model system in this context because their shells are preserved as fossils and we know that they have existed before the Isthmus closed. Hence, I can calibrate the rates of molecular evolution with the closure of the Isthmus. By studying several populations of hosts and bacterial symbionts, I will be able to use population genetic theory to inform how this symbiosis evolves in response to changing environmental conditions.


**Keywords:** Microbiome, symbiosis, evolution, ecology, allopatr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Decoding the Biochemistry of Terpene Synthases' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Enzymes are biological catalysts indispensable for biotechnology. Conventional approaches to enzyme design and optimization, relying on biochemical intuition and combinatorial mutagenesis, have yielded significant success over decades. Building on these foundations, the TerpenCode project aims to instantly elucidate and engineer enzymatic reactions by designing a new generation of deep learning models that (1) incorporate biochemical principles as inductive biases and (2) model all intermediate biochemical transformations that occur sequentially in the active site of each enzyme. We will focus on terpene synthases, which produce the core hydrocarbon scaffolds of terpenoids, the largest and most diverse class of natural products. My group has already curated a comprehensive training dataset comprising thousands of terpene synthase reaction mechanisms. In Objective O1, we will develop deep learning models for predicting the substrates, products, and reaction mechanisms of terpene synthases directly from their amino acid sequences. In Objective O2, we propose to engineer a generative machine learning algorithm for designing new variants of terpene synthases with altered quantitative product distribution, adjusted product stereochemistry, or new reaction cascades that lead to novel terpene products. We will experimentally validate these models by yeast expression experiments, including complete chemical structure elucidation of the detected reaction products. Breakthrough progress on these objectives would be a key important step towards the holy grail of biotechnology: providing a computational prediction of the exact enzyme function from its amino acid sequence and instant de novo generation of new enzymes for catalyzing desired biochemical reactions for an important clas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Support stakeholders in zero emission fossil fuel power plants and energy intensive industry' (SSFZEP).

assistant: **Concept**

This proposal is submitted in response to call LC-SC3-CC-4-2018. The overarching goal of this project is to draw together a broad, effective and inclusive network of Carbon Capture and Storage (CCS) and Carbon Capture and Utilisation (CCU) – hereafter referred to as CCUS – stakeholders to support the development of zero emission fossil fuel power plants and energy intensive industries. Supporting the coordination of diverse stakeholders - including the private and public sectors - will contribute to a common agreement on the role that CCUS technologies can play in the transition to a low-carbon economy. This proposal will support the coordination of the stakeholders’ activities through the SET-Plan CCUS European Technology Innovation Platform (ETIP). A key activity of the ETIP will be to support progress of the CCUS Research and Innovation (R&I) activities contained in the SET-Plan CCS and CCU Implementation Plan . The Implementation Plan was developed by a temporary working group and adopted by the Set Plan Steering Group on 27th September 2017. The Implementation Plan R&I activities will support delivery of the SET-Plan targets agreed for Action 9 on CCS and CCU.           This proposal is to continue the ETIP ZEP activities supported through the project SESZEP funded under LCE-36-2016. The grant for this project ends on the 30th of April 2018 and so there will be a gap in the support to the ETIP stakeholders. If this proposal is successful we would wish to start providing support to the stakeholders at the earliest possible opportunity in order to minimise disruption . If this proposal is successful we would like to discuss the options for a timely start for these services with the Commission.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'On-site remediation of ground water contaminated by polar organic compounds using novel adsorption technology' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Problems to be solvedGroundwater is the main source for drinking water production in most regions of Europe. In many areas this groundwater is contaminated by a variety of mainly organic pollutants threatening the drinking water supply in the future. Existing methods for remediation of groundwater have limitations and disadvantages, in particular, when used on-site. In general, very polar compounds have not been removed by these techniques.Scientific objectives and approachA novel technology will be developed which allows the removal of organic contaminants from polluted groundwater. Groundwater clean up is achieved by adsorption of the pollutants onto organic polymers of small particle size packed in radial beds. The surface of the polymer particles will be modified to reduce pore plugging. After loading with pollutants the polymers can be regenerated on-site. Explosives and phenols have been selected as model compounds to test this new technology. Contamination by these compounds is widespread in Europe. Moreover, they are representative for polar compounds in general, which are difficult to remove from groundwater. The project starts with laboratory studies on the adsorption process (determination of adsorption isotherms and breakthrough volumes) followed by laboratory studies on the regeneration process. Based on the results of laboratory studies mathematical simulation models will be developed which allow the design and finally the construction of the pilot plant. In the final part of the project this pilot plant with a capacity of 1 - 3 m³/h will be tested in the field and further optimized.Expected impactsIt is expected that the new technology allow an efficient remediation of polluted groundwater also in remote areas, as one means to ensure the sustainability of