RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Equinom computational breeding system' (ECBS) targeting Horizon 2020.

assistant: **Abstract**

Protein is critical to human health, but the way we produce and consume it today presents many challenges, both in terms of global consumption patterns as well as their social, environmental and economic impacts. Consumers, aware of the impact a carnivorous diet has on health, animal welfare, and the environment, aim to replace animal products with plant-based protein-enriched products, which explains an increasing demand for clean-label plant-based protein-rich products. However, of the total plant protein produced, less than half is used for human consumption, with just three crops (maize, wheat and rice) accounting for about 50% of the world’s consumption of calories and plant protein. Regarding the EU, the European Union is suffering from a major deficit in vegetable proteins mainly due to the needs of its livestock sector, being dependent on imports from third countries. In order to put an end to this dependency, the EU is building a strategy to promote protein crops, encouraging the production of protein and leguminous plants in EU’s agriculture. On the other hand, the lack of cost-effective plant-proteins diversity (dominant species are soy and pea), organoleptic and functional challenges, and low protein content and quality, is holding-back the market. The food industry is therefore unable to satisfy consumer demand for affordable tasty plant-based protein-enriched products. Via our advanced and non-GMO computational breeding technology (ECBS), we are able to develop customized crops based on the food industry needs, i.e. with those traits required by the industry. This cost-efficient technology enables to create crops with specific traits much more accurately (>10 times higher). On that basis, to meet the current plant protein needs in the industry, we are able
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Strengthening the multifunctional use of European land: coping with marginalisation', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The project will address how multifunctional land use can cope with marginalisation and land use change. The project will:(1) identify areas most vulnerable to marginalisation of agriculture in seven countries at national level;(2) develop a set of tool s and scenarios for recommendations for appropriate land use based on a selection of ecological, cultural and socio-economic criteria for policy and decision makers at the EU, national and municipal level.(3) study the role of the CAP in the process of marginalisation and developing of tools and recommendations for appropriate land use.(4) assess the viability of multifunctional land use given the vulnerability to and acceptability to marginalisation, and CAP
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Accurate simulations of strongly correlated systems with tensor network methods' (TENSORNETSIM).

assistant: **Innovation**

This project aims to achieve ground-breaking advances in the biggest challenge in computational condensed matter physics: the accurate simulation of strongly correlated systems (SCS), which give rise to fascinating phenomena such as high-Tc superconductivity (HTSC), quantum spin liquids with topological order, and other exotic phases of matter. While for one-dimensional (1D) systems tremendous progress has been made thanks to the famous density-matrix renormalization group (DMRG) method, in higher dimensions accurate methods have been lacking for many years. Recently, I achieved several major breakthroughs with tensor network methods, which can be seen as an extension of DMRG to higher dimensions. I was able to show that these methods outperform previous state-of-the-art approaches for several challenging models, making it clear that these methods will play a pivotal role in understanding SCS in 2D, in the same way as DMRG has revolutionized the study of 1D systems.The goal of this project is to build upon these breakthroughs and to develop the next generation of tensor network methods to simulate relevant open problems in SCS with an unprecedented accuracy, in order to make substantial progress in understanding the physics of these systems. Milestones of this project include:- development and improvement of 2D tensor network methods for finite temperature simulations, the computation of excitation spectra, and the classification of topological states, and pioneering work with tensor networks for 3D systems- accurate simulation of the 2D Hubbard model to answer the longstanding question if it captures the essential features of HTSC - study of extended Hubbard models to understand which ingredients are really essential for HTSC- prediction of novel phases of matter in SU
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Recombinant measles virus as a vector for HIV vaccines' (RMVHIV) under Sixth Framework.

assistant: **Objectives**

Twenty years after the discovery of human immunodeficiency virus (HIV)as the causative agent of the acquired immune deficiency syndrome (AIDS) a vaccine to prevent virus infection or mitigate disease is still not available. Accumulating data suggest that CD8-positive T cells play an important role in the control of HIV in the infected host. Therefore, several vaccine strategies based on DNA or recombinant viral or bacterial vectors have been devised to induce this type of immune response, and some of th ese vaccines are in early clinical testing. This proposal aims at demonstrating the safety and immunogenicity in humans of a novel recombinant measles virus (MV) vector for use as an AIDS vaccine. The vector is replication competent in vivo and is deriv ed from a widely used measles vaccine strain (Schwarz), which is known to induce very long lasting immunity. Therefore, this novel vector potentially offers a unique combination of safety and potency. The recombinant HIV MV vectors will express three re latively conserved HIV proteins (Gag, Pol, Nef) from HIV clade B and A strains. A good manufacturing practices (GMP) compatible production process for the recombinant MV vector will be developed and a GMP lot will be produced for two clinical studies. Th e first study will evaluate the safety profile of the MV vector, while the second study will assess in addition the immunogenicity in MV-immune volunteers. With these two clinical studies, the project will specifically address potential shedding of the r ecombinant vector into the environment and the potential negative impact of pre-existing MV immunity. It is expected that at the end of the project sufficient clinical data on the safety and immunogenicity will have been generated to decide on subsequent advanced technical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovative quality control methods for rotating machines using artificial intelligence methods' (INQUAC).

assistant: **Innovation**

Objectives and content The project addresses the needs of manufacturers of rotating machines like gearboxes and electric motors for the purpose of final product test. The technical approach is the development of a trainable, artificial intelligence based inspection system. The system will be introduced into the assembly line for the purpose of real-time in-line quality control. Output of the system is a fault diagnosis, received by the evaluation of complex acoustic signals. Environmental conditions like aging of test bench mechanics, the influence of spare parts to the classification result, and an optimised sensor concept will be considered. End-user 1, a domestic machine manufacturer, and End-user 2, an electric motor producer, anticipate cost savings in a volume of several hundred kECU per year by automatic test procedures, and well defined fault diagnosis.In the case of End-user 3, a manufacturer of gearboxes, an objective and reliable test is necessary with a reproductive accuracy of 3 dB compared to present 12-15 dB. The inspection system will detect and classify minimum 95% of the most frequent faults like missing parts, faulty assembled components, faulty gear mesh noise. These faults must be detected in an incipient and well-defined stage. The inspection system must work in real-time. A fault classification rate of at least 97% is envisaged. The consortium consists of three end-users, two SMEs and three research institutes universities. The end-users are first users of the inspection system under development; the end-users have complementary applications. The product ranges of the SMEs involved are complementary as well as the expertise of the research organisations BE97-4872.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Deciphering female’s SEx hormones - MIcrobiota interactions during a menstrual CYCLE for an efficient personalized medicine in cardiometabolic disorders' under Horizon Europe.

assistant: **Concept**

Cardiometabolic disorders (CMD), a group of conditions that include cardiovascular diseases, type 2 diabetes and metabolic syndrome, are characterised by dysfunction of glycaemic and/or lipid metabolism. Clinical manifestations, severity and progression are different between sexes, the underlying mechanisms of which are largely unknown. The poorer prognosis in women globally calls for an urgent need for better women’s tailored prevention and treatment strategies. Still, for an efficient personalised strategy, female-specific mechanisms have to be identified. The SEMICYCLE project will systematically investigate female’s sex hormones-microbiota interactions to unravel female-specific microbiota features regulating glycaemic and lipid metabolism in women during homeostasis and diseases. Findings of this research project will pinpoint key mechanisms useful to improve current prevention and diagnostic tools as well as therapeutic options of CMD. SEMICYCLE will follow up 300 healthy women during one menstrual cycle and longitudinal cross-omics data (five layers of information from host genome, gut microbiome, gut metabolome, vaginal microbiome, plasma proteome) will be generated, analysed and integrated with female sex hormones variations, lifestyle and diet, glycaemic and lipid phenotypes using state-of-the-art methodologies and computational approaches. Subsequently, mechanisms identified during homeostasis will be investigated for association with CMD onset and progression, using already existing cohorts totalling more than 10,000 samples. This research is based on my expertise and that of my research group in generating and analysing omics data in large data sets. Findings will reveal previously unknown microbiota regulators of CMD in women thus offering alternative rout
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Revolutionising Organic Synthesis: Efficient One-Pot Synthesis of Complex Organic Molecules for Non-Experts' in the context of a Seventh Framework call.

assistant: **Objectives**

The creation of new molecular entities and subsequent exploitation of their properties is central to a broad spectrum of research disciplines from medicine to materials. However, despite substantial progress, the problems and difficulties associated with chemical syntheses severely limits the development of these disciplines. In order to meet the emerging challenges across new disciplinary boundaries in a rapidly changing scientific landscape we require a step-change in the development of more rapid and robust techniques in organic synthesis. Our plan is to develop new reactions and strategies which enable us to essentially grow a carbon chain with complete control over its shape (stereochemistry) and functionality (which groups are incorporated). Specifically, we propose to create a family of chiral carbanions with good leaving groups attached which can be inserted into C-B bonds sequentially and in one pot so that at the end of the operation a complex natural product, pharmaceutical or material will be produced. Our ultimate vision is to render complex organic synthesis as easy as peptide/oligonucleotide synthesis is now by attaching the boronic esters to a solid support and automating the steps. This would enable complex organic molecules to be accessible even by non-experts in synthesis. Furthermore, by variation of the reagents and their stereochemistry any compound and any stereoisomer will be accessible thus allowing diversity elements to be introduced without additional cost. The impact for organic synthesis and the wider scientific community is immense as it will allow the properties and potential function of complex molecules (from pharmaceuticals to materials) to be studied and then exploited. It is enabling science.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Long-term synaptic plasticity in interneurons: mechanisms and computational significance'.

assistant: **Innovation**

Memory encoding occurs by strengthening or weakening of synapses among principal neurons. However, excitatory synapses on some inhibitory neurons in the hippocampus also exhibit use-dependent long-term potentiation and depression (LTP and LTD), with important consequences for network homeostasis and information processing. This proposal addresses the following areas: 1. Although the rules determining which forms of plasticity occur at which synapses are emerging in the hippocampus, relatively little is known in other parts of the brain involved in cognition, movement initiation and emotion. We will use electrophysiology, optical imaging and mouse genetics to map out the expression of activity-dependent plasticity at excitatory synapses on inhibitory neurons in the cortex, striatum and amygdala, and relate these to the biophysical and pharmacological properties of the neurons and synapses involved. 2. Although one form of interneuron LTP resembles plasticity in pyramidal neurons, another form requires Ca2+-permeable AMPA receptors and metabotropic glutamate receptors for its induction, and shows features suggestive of pre-synaptic expression. A similar dichotomy exists in two forms of LTD, which depend on either NMDA or Ca2+-permeable AMPA and metabotropic glutamate receptors. We will test the involvement of candidate intracellular and trans-synaptic signalling cascades to understand the mechanisms triggered by distinct conjunction patterns of pre- and post-synaptic activity. 3. What is the computational significance of LTP and LTD in interneurons? The elemental computational roles of different GABAergic interneurons and their firing patterns during behaviourally relevant brain states are beginning to emerge. How synaptic strengthening and/or weakening interact with thes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Controlling interfacial spin effects in magnetic devices through applied electric fields'.

assistant: **Concept**

Sandwiching ultra-thin out-of-plane magnetized materials between heavy metal and oxide layers in multilayer heterostructures has led to important new discoveries which offer a path to fast, non-volatile, low power electronics. The first important effect, the Dzyaloshinskii-Moriya interaction (DMI), favours orthogonal alignment of neighbouring spins, causing stable Néel domain walls of well-defined chirality. The second, spin-orbit torques (SOTs), are torques on the magnetization caused by spin accumulation under applied in-plane currents. In combination these effects lead to very high domain wall velocities and allow the creation of mobile topological objects called skyrmions, both suitable for technological applications. While DMI and SOTs are dominated by the interfaces, their precise microscopic origins are not well understood. This proposal takes advantage of newly developed techniques to control magnetic interfaces with electric fields. Through strain effects, created by electric fields on a ferroelectric layer, or through electrical fields across an insulating oxide or through electric field-induced oxygen migration in an ionic conductor, the interfacial properties of suitable devices will be altered. All these effects change the filling of hybridized interfacial electronic orbitals, which allows the strength of the DMI and SOTs to be tuned for applications and lead to a better understanding of the underlying mechanisms.  Magintlec will be conducted at Aalto University where the host group provides frontier expertise and state-of-the-art experimental facilities for electric-field controlled magnetism (film growth, lithography, magnetic and magnetotransport characterization). The applicant, Dr Rhodri Mansell, brings an excellent track record in nanomagnetism and sp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Combinatorial synthesis of beta-lactones and beta-lactams as potential inhibitors for Cdc25A phosphatase; an interesting target for anti-cancer drugs' (FJDEKKER04).

assistant: **Innovation**

Combinatorial chemistry has emerged as very powerful tool for drug discovery. However, increasing the library size does not necessarily result in many new hits and lead compounds. Because the number of thinkable organic compounds is almost infinite, there are quest arises for a biologically validated starting point in library synthesis. Natural products that bind to certain protein domains might provide such biologically validated starting points. Recent discoveries reveal that three-dimensional folds of different protein domains are often similar and that the number of distinct protein domains and families is fairly limited.Based on this it can be envisioned that natural products that bind to one member of a protein domain family can be used as a guiding principle to design ligands that bind to other members of the same protein domain family. This proposal focuses on the natural product tetrahydrolipstatin (THL) that binds to gastric and pancreatic lipase, which have high three dimensional similarity with the C dc25A phosphatase. This phosphatase has an important role in progression of the cell cycle and is thus a target for anti-cancer drug development. Combinatorial libraries inspired by the THL core structure will be assembled and screened for Cdc25A phosphatase activity, which will ultimately lead to a new generation of anti-cancer drugs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High reach innovative mobility solutions to cope with transport poverty' (HiReach) under Horizon 2020.

assistant: **Objectives**

HiReach aims to eliminate transport poverty by triggering new mobility solutions sustained by products scaling up on mixed needs, backed by mobile information technologies and social innovations, using open tools, technology transfer and startup development techniques to find and exploit new business ideas that reach low accessibility social groups and areas.HiReach builds on the potential of bundling and mixing dispersed, special and non-coordinated/optimised trip requests and needs from different vulnerable user groups to favour inclusive and participated vs. exclusive/special and geographically-limited mobility. By combining different attributes of available transport concepts and bottom-up initiatives with new operational schemes and IT applications, HiReach will explore viable business models for small scale, modular and easily replicable mobility services (e.g. community transport services, ridesharing, minibus pooling, etc.) that can be provided at affordable prices and/or with minimum subsidies. HiReach fosters social innovation processes through an in depth (micro)analysis of capabilities and attitudes of different social groups and their direct involvement as co-users and co-owners of the proposed solutions. Their involvement will be put in relation with the HiReach mechanism for exploring, generating and testing new solutions which is based on the creative work of startups and innovative entrepreneurs.To secure the validation and scaling-up of new business models, HiReach will provide open source tools, guidance and targeted funding to developers as well as testbeds for new inclusive mobility solutions jointly prepared by startups, policy makers and local communities. The legislative and regulative adaptation of newly developed collaborative economy solutions