RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Real-time inversion using self-explainable deep learning driven by expert knowledge'.

assistant: **Innovation**

IN-DEEP is a European Doctoral Network composed of nine doctoral candidates (DCs) and top scientists with complementary areas of expertise in applied mathematics, artificial intelligence, high-performance computing, and engineering applications. Its main goal is to provide high-level training to the nine DCs in designing, implementing, and using explainable knowledge-driven Deep Learning (DL) algorithms for rapidly and accurately solving inverse problems governed by partial differential equations (PDEs).Inverse problems in which the unknown parameters are connected to experimental measurements through PDEs cover from medical applications - like cancer growth assessment - to the safety of civil infrastructures, and green geophysical applications such as geothermal energy production. Their application value is measured in human lives and society's well-being, which goes beyond any quantifiable amount of money. This is why equipping a new generation of specialists with highly-demanded skills for the upcoming transition toward safe and robust AI-based technologies is imperative.Despite the promising results in many applications, DL for PDEs has severe limitations. The most troublesome is its lack of a solid theoretical background and explainability, which prevents potential users from integrating them into high-risk applications.IN-DEEP aims to remove these constraints to unleash the full potential of DL algorithms for PDEs. We will achieve this by: (a) focusing on emerging applications of DL for PDEs with immense societal and/or industrial value, (b) designing mathematics-infused advanced solvers to address them efficiently, and (c) involving, from the beginning, industrial and technological agents which can monitor, upscale, and exploit this knowledge. On the way, we shal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ORBITS, CRYSTALS and REPRESENTATION THEORY', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Representation Theory is presently undergoing a spectacular To ensure a continuing tradition of excellence the network aims to provide development with new insights coming from both Theoretical Physics and training through personal contact and through advanced courses at graduate and postdoctorial level. All centres have at least one senior member who be other areas of Pure Mathematics. The network aims to strongly enhance the able to provide expert guidance and overall this will cover practically all European contribution to this field through close cooperation between teams in both Europe and Israel drawn from many of the finest the topics within the programme. The network will support roughly 80 mathematicians actively involved in these exciting developments.The postdoctorial months per year, exchange of Junior Researchers and a total of seven conferences over the three-year period. These activities will all proposed research extends over the full range of algebraic and geometric have both a training and research content. topics having as common base the rich and intricate structure of semisimple algebraic groups. The project will tackle open problems in the following areas: 2) Development and applications of crystal bases. 4) Developments emanating from the Functorial Approach (Geometric Langlands Conjecture, Localization, Topological invariants).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'EM safety  and Hazards Mitigation by proper EV design' to be submitted under Seventh Framework.

assistant: **Abstract**

The project aims at increasing the public confidence in the safety regarding electromagneticfields (EMF) in the fully electric vehicles (FEV).Public expectations to move towards the electrification of road transport are driven by a multitudeof factors and concerns including: climate change, primary energy dependence and public healthas well as cost and scarcity of raw materials. Road transport remains the main source of manylocal noxious emissions including benzene, 1,3-butadiene, carbon monoxide (CO), nitrogenoxides (NOx) and particulate matter (PM). Within urban areas, the noxious emissions due to roadtransport are particularly high. There is a growing body of evidence linking vehicle pollutants tosevere health effects such as respiratory and cardio-pulmonary diseases and lung cancer. Ingeneral according to the World Health Organization the emissions from car exhausts areresponsible for more deaths than road accidents.On the other hand, there is widespread public concern regarding the possible adverse effects ofelectromagnetic fields (EMF). Thus, there is a need to avoid the spread of panic or unjustifiedfears that would delay the enormous and crucial economic and environmental benefits that theFEV can provide when deployed on a large scale.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrating sensor and verbal information to infer the structure of a mobilerobot environment' (1994-1998).

assistant: **Concept**

This project focuses on the integration of sensor information and linguistic descriptions in order to guide the navigation of a robot that works in previously unknown environments. Route and office descriptions provided by persons that know the working area will be used to obtain general information of the kind of objects to be found and their global distribution in the environment. Ultrasonic sensors will provide metrical information of the environment outline, while vision will be used for object identification in order to solve conflicts, confirm expectations and focus on areas of interest. In this way, we will use three independent sources of information, each one of different nature and characteristics, but complementary among them in such a way that from their integration we can obtain the necessary information to solve the navigation tasks. We will also consider the problems of how to represent and propagate (using fuzzy sets) the uncertainty that is inherent both to the linguistic descriptions and to the perceptual information. Particular importance will be given to experimentation with the mobile robot already available at the host institution. This project proposal combines fields of research where the applicant has already a long experience with other fields that are new to him and where he can strongly benefit from the knowledge and expertise form the members of the host institution. The training he will acquire is also of significant interest for his research centre at his country of origin in order to continue this research line at the end of this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Decoding multimodal TBI markers for optimized recovery' (NeuroVitalizer), addressing dissemination and exploitation.

assistant: **Impact**

Traumatic brain injury (TBI) occurs when mechanical forces shake the brain and disrupt normal brain function, affecting biological processes like cellular, molecular, and electrical functions. These processes are highly interconnected, making it difficult to fully understand TBI recovery with traditional single-discipline methods. Current approaches often fail to address the complexity of TBI even in mild to moderate cases, creating an urgent need for new methods to overcome existing limits in data collection, integration, and interpretation across multiple subdisciplines.In this project, I will set up a new framework for a comprehensive and systematic analysis of recovery processes post-trauma and the effect of electrical stimulation (ES) in in vitro models for mild to moderate TBI, which allows for a detailed examination in a controlled environment. Our experimental workflow will integrate insights on cellular morphology and structure from microscopy images, electrical activity, and network synchronization from multi-electrode array recordings, protein expression changes from immunostaining, and cell viability and stress markers found in the cell medium. Calcium imaging will provide insights into ionic homeostasis maintenance. An AI-driven data fusion approach will facilitate the analysis of these multimodal datasets revealing hidden patterns and relationships that traditional approaches cannot uncover.Specifically, we want to address questions such as•How do astrocyte protein expression and neuronal electrical activity relate to repair after TBI?•To what extent can ES prevent neuronal death, and what are the best stimulation protocols? When should we start the treatment?•Are there early biomarkers that can predict recovery success or delays?This project introduces a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'NEXT generation methods, concepts and solutions for the design of robust and sustainable running GEAR' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The rail sector has recently seen only limited changes in running gear.The rail sector has recently seen only limited changes in running gear. A reason is that innovations have the tendency to increase the first cost of the running gear while they reduce the LCC by reduce maintenance costs. The long-term cost reduction, however, is not easy to quantify. This dilemma will be addressed in WP1 where an updated Universal Cost Model based on the one from the Roll2Rail project will be developed that makes it possible to judge the economic impact of the innovation suggested for an operator using the vehicle. How can the costs for buying, operating and maintaining the vehicle be influenced? Lower bogie weight would reduce wheel-rail forces and allow for higher payload. In WP2, the project is going to suggest ideas that are based both on the use of new materials and new manufacturing methods. Simulation techniques will be explored to allow optimisation of designs. It will be investigated whether required properties of the running gear such as stiffness and damping could be distributed through the structure rather than requiring specific components. In parallel, active control strategies will be investigated to improve the level of ride comfort or reduce wheel and rail damage. The wheelset is another extremely important and safety-critical component in a rail vehicle.  Since it represents a so-called “unsuspended mass” there is a desire to minimize the wheelset weight. The main objective of WP3 is a feasibility study on the use of composite materials for the construction of railway wheelsets. Technology concepts for a lightweight wheelset will be defined. Main focus areas are material selection, durability, manufacturing process and joining methods.The output of this project will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Two facets of viral RNA: mechanistic studies of transcription and replication by influenza-like viral polymerases and detection by the innate immune system'.

assistant: **Innovation**

RNA viruses infect cells to replicate and repackage their genomes in progeny virions. In response, the cellular innate immune system detects viral RNA and triggers powerful anti-viral countermeasures. This proposal aims to elucidate atomic resolution molecular mechanisms associated with these conflicting interests, and will address the following questions: firstly, how do RNA polymerases of segmented, negative sense, single-stranded RNA viruses such as influenza and bunyaviruses transcribe and replicate viral RNA and secondly, how do RIG-I like helicases, intracellular, innate immune, pattern recognition receptors, selectively detect RNA only of viral origin, thus triggering interferon production and induction of the anti-viral state? A third, more exploratory part of the proposal will use proteomics analysis to identify all host factors that are bound to viral mRNAs in influenza virus infected cells. The interdisciplinary project will combine state-of-the-art structural biology with cell-based functional assays and global analysis. Results will advance fundamental understanding of polymerases and helicases, both complex RNA-dependent molecular machines, give new insight into the regulation of innate immune receptor activation and signalling, and shed new light on RNA metabolism in the perturbed environment of the infected cell. They will also impact virology and public health by bringing new knowledge on RNA virus-host interactions, virus evolution and inter-species transmission. More pragmatically the project will boost structure-based anti-viral drug development targeting serious and/or emerging human pathogens such as influenza A, which poses the perennial threat of a devastating pandemic, and the many disease causing bunyaviruses, which in a globally warming world
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigating the interplay between VWF, platelets, and neutrophil extracellular traps in pathologies involving thrombosis of the microvasculature' (2014-2020).

assistant: **Concept**

Thrombosis is a complex process involving activation of endothelial cells, and their release of Weibel-Palade body contents such as von Willebrand factor (VWF) and P-selectin. This in turn recruits platelets which form aggregates, and leukocytes such as neutrophils. The recent discovery of neutrophil extracellular traps (NETs) described a novel antimicrobial function of neutrophils.  NETs are extracellular chromatin strands containing microbicidal proteins. The release of histones, serine proteases, and myeloperoxidase concentrated on DNA fibers into the extracellular space can contribute to many pathologies. NETs can bind platelets and red blood cells and therefore also contribute to thrombosis.  Activated platelets can in turn stimulate neutrophils to make NETs, creating a vicious thrombo-inflammatory cycle. Our first objective is to study VWF involvement in the induction of NETosis. We will elucidate the role of VWF as an important mediator of NET formation using VWF mutants.  Innovative live-cell imaging and flow cytometry will be used to unravel the kinetics of VWF/platelet-mediated NET formation. Our second objective is to assess the physiological relevance of (inhibiting) platelet/VWF involvement in NETs-related pathology. We will investigate the role of VWF/NET interactions in three critical clinical settings where microvascular thrombosis contributes to multiorgan failure and/or mortality: sudden inflammatory response syndrome (SIRS), thrombotic thrombocytopenic purpura (TTP), and severe malaria. Mouse models of disease will be used and combined with several strategies for inhibition of VWF/platelet/NETs interactions to assess their effect on disease progression. In summary, with this research project we aim to better understand how platelets and VWF can drive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Shaping up for mitosis: the origins and consequences of the 3D structure of mitotic centromeres' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The centre of the iconic X-shape of human chromosomes is the centromere. It is an extensive locus of specialised chromatin that assembles the kinetochore machinery to connect chromosomes to spindle microtubules for their correct segregation during cell division. How these centromeres obtain three-dimensional (3D) structures that coordinate assembly of kinetochores and resist substantial microtubule-based pulling forces is unknown. We discovered that vertebrate chromosomes are naturally dicentric: their centromeres are two-domain (‘bipartite’) structures, irrespective of underlying DNA sequence or position along the chromosome. Bipartite centromeres assemble bipartite kinetochores that connect to double microtubule bundles, fundamentally altering our view on chromosome-spindle interactions. Chromosome segregation errors in cancer are marked by split centromeres, linking centromere structural integrity to chromosomal instability. Our findings raise many elementary questions about the molecular origins, the 3D structure and the functional consequences of a bipartite mitotic centromere. In CENTROSHAPE, we will integrate advanced imaging and sequencing technologies with state-of-the-art cell models of neocentromeres, inducible centromeres and cancer, to uncover:-How centromere bipartition originates and is maintained,-What 3D chromatin structure shapes the bipartite centromere, and-How destabilisation of bipartite centromeres predisposes to chromosomal instability and centromere damage.The results of CENTROSHAPE will illuminate a hitherto ‘dark’ region of vertebrate mitotic chromosomes – the 3D organisation of centromeres. They will inform on the mechanisms that create this highly specialised chromatin domain in dividing cells and contribute to our understanding of the origi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Supercritical fluids to extract and / or degrade organic waste materials especially flame retardants' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Objectives and content Carbon dioxide and water at supercritical conditions are the basis of powerful methods to extract materials and to degrade or oxidise the extracts fully to minerals without organic solvents. All emissions are under complete control including the oxidation product CO2. It is the objective to develop a highly effective process which is a combination of extraction by C0 for treating mass consumer or industrial wastes and the degradation of these extracts by supercritical water to obtain minerals for re-use (SCE/SCWO). The innovative idea is: moderately contaminated materials are subjected to condition of supercritical CO2; these extracted materials are than concentrated and subjected to the stronger conditions of supercritical H 2 O. The model application will include wastes of electronic mass consumer goods containing substance like flame retardants which induce problems on recycling. About 650.000 t/year of flame retardants are produced worldwide, and today's disposal is in-adequate. The process should be adaptable to other important waste problems in chemical and pharmaceutical industry for treatment of wastes and soil contaminated with halogenated organics. Within the work programme the basic processes have to be investigated to end up finally with a model plant. Tasks will be to design and construct the SCE-extractor, the SCWO-reactor, the interface and the installation and testing of the model plant based on modelling of the flow fields Sensors, electronics and control devices have to be developed for on-line monitoring. To prepare later exploitation applicability to problems of similar substances to be extracted will be studied. An up-scaling concept includes economic and ecological considerations and defines a product to be later introduced t