RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Novel vinca alkaloids analogs as anticancer agents: a multidisciplinary quest' (VVINCANCER).

assistant: **Concept**

Small natural molecules represent an irreplaceable tool in the search for new agents and new directions in medicinal chemistry. In the cancer treatment area, the 79.8% of the new chemical entities approved for drug use from 1981 to 2006 were registered as naturally derived or inspired. The organic synthesis of natural product analogs of varying degrees of structural complexity is a powerful way of providing new drugs, improving ADME (Absorption, Distribution, Metabolism, Excretion) properties, fighting drug resistance and performing SAR (Structure-Activity Relationship) studies. The current project concerns the joint use of a synthetic methodology recently developed at the host group and of in silico modeling, for the synthesis of vinca alkaloids analogs. The vinca alkaloids and their analogs are mainstays of cancer chemotherapy, as they are able to bind tubulin and interfere with microtubule formation in mitosis, however the structural diversity of this group of drugs is very poor, with scarce divergence from the original natural products. The potential of the planned approach consists in the possibility of generating natural products analogs with key differences in the core structure, that are unprecedented in respect to “state-of-the-art” analogs syntheses and are not accessible through derivatization of the natural products or modification of their biosynthetic pathway. The newly synthesized chemical entities will then be examined both for their bioactivity (as anticancer agents) and for their pharmacological profile in collaborations with leading experts. The project presented herein merges Organic Chemistry, Biology and Pharmacology in a multidisciplinary quest that will certainly represent a high-quality contribution to cancer research in Europe and may be the ba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Geometric Manufacturing Solutions for Freeform Shapes'.

assistant: **Concept**

Freeform shapes represent one of today's important manufacturing challenges. This applies to numerically controlled (NC) machining of parts to be produced in large amounts as well as to outer surfaces and subconstructions for unique designs in modern architecture. However, currently no systematic method exists which could reconcile the competing aims of faithfully reproducing smooth surfaces with their efficient segmentation into easily manufacturable parts. GEMS aims to overcome this challenge by a geometric approach: We consider surfaces generated by the motion of either a milling tool or a profile curve, and investigate their properties and approximation power. Our ultimate goal is to algorithmically determine a segmentation of freeform surfaces into parts exactly manufacturable by a single sweep. This amounts to highly nonlinear optimization with side conditions originating in both geometry and manufacturing and requires a detailed shape analysis. Subsequently these mathematical results have to be expressed in terms of manufacturing processes, such as NC milling, styrofoam cutting, or the building of molds from a sequence of simple curves. Successful completion of this research would mean a very significant contribution to the manufacturing of freeform shapes, and indeed some complex tasks will be made feasible for the first time. We strongly believe that the proposed consortium of five partners has the capacity and knowledge to achieve success: (1) ModuleWorks, a leading provider of CAD/CAM software components (2) TU Wien, a university with deep knowledge in geometry processing and differential geometry (3) Technion, an internationally renowned technical school very successful in computer aided geometric design (4) Evolute, a high tech start up company specializing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel Design of Nanostructures for Renewable Energy:Fundamental Questions and Advanced Applications' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Photovoltaics and liquid fuels are poised as major contributors to the global energy market, promising cleaner, renewable sources of energy than fossil fuels. However, the technologies required to make this possibility a reality are limited by their high cost per kWh, and current share of photovoltaics and liquid fuels in the energy market is thus extremely small. One method of reducing the costs of photovoltaics lies in the use of semiconductor nanocrystals to absorb and convert solar photon energy to usable electricity and liquid fuel. Among the advantages of a nanocrystal-based design for photovoltaics are the requirement for thinner absorbing layers, the less energy-intensive refining processes, and their scalability with respect to photovoltaic production.To address these challenges, I plan to initiate a multidisciplinary research project that comprises three separate, but interrelated and complementary, parts that will be conducted in parallel. The first and the main part will be the preparation of novel hybrid nanostructures that have potential for PV and fuel cells applications. The second will focus on a systematic study of the fundamental processes of charge dynamics in the nanoscale regime. The materials and knowledge generated can then be applied in the third part of the project—development of PV and photoelectrochemical devices with scale-up potential for large-scale solar energy exploitation, and examination of benchmark properties (overall efficiency, I V characteristics, external quantum efficiency, hydrogen and liquid fuel production) of our new hybrid materials and devices. These properties will be used as feedback for the synthesis of more complex hybrid structures and for improving our device assembly methods and the choice of materials and/or compos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mombasa cervical cancer screening project' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The MCCSP operational research project aims to address the important public health issue of screening for cervical cancer in developing countries through the assessment of different methods for cervical cancer screening (papanicolaou (PAP) smear, visual inspection with acetic acid (VIA) and testing for human papilloma virus (HPV)) in field conditions as alternative screening methods for poor resource countries. The project will also evaluate the performance of the out-patient treatment methods loop electro excision procedure (LEEP) and cryotherapy in field conditions. A Community outreach approach will be used to try to enhance coverage of the at risk women for cervical pre-cancer. The research will be carried out in 5 primary health centres and one referral centre in Mombassa, Kenya.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Growth of size-determined metal nanoclusters on gold substrates and study of their redox and electocatalytic behaviour', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content (i) Growth of clusters of Silver, Copper, Platinum, Palladium of nanometer dimensions (typically < 5nm diameter) in preformed nanometer sized holes in Au(111) single crysal surface as substrate, and ascertain the correlation between deposition overpotential and cluster size. (ii) Investigate the electrochemical properties of the size-determined nanoclusters and compare with those of the bulk metal. The redox potential for oxidation of the nanoclusters will be determined as a function of their size. (iii) The electrocatalytic behaviour of these clusters will be investigated as model systems for active sites which are of vital importance in heterogeneous catalysis and electrocatalysis. The use of nanoclusters as model systems for catalytic processes is of major industrial importance. Training content (objective, benefit and expected impact) Use of modern very high resolution surface techniques (not available in Cork) to produce and investigate minute features on surfaces and interfaces. Exposure to wide variety of ancilliary techniques and expertise.  Links with industry / industrial relevance (22) Nanocluster behaviour is of major significance in areas such as catalyst / electrocatalyst development, microelectronics and microfabrication technology - these are areas of major and increasing importance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Adaptive redox regulation in inflammatory macrophages' (2021-2027).

assistant: **Innovation**

Macrophages are key players of the innate immune system and as such maintain homeostasis, initiate inflammatory and redox responses for pathogen defence, but also regulate resolution of inflammation. Supporting these functions are distinct metabolic programmes, which underlie macrophage functional phenotypes. While recent advances have improved the understanding of macrophage metabolic programmes supporting specific activation states, it remains unclear how the redox system is regulated in macrophage activation states and during pathogen defence. Here, I propose to investigate how redox adaptation is regulated during macrophage activation and its impact on functional phenotypes. I will focus on the following three aims: Firstly, I will quantify expression of cystine transporter SLC7A11, which, by importing cystine supports glutathione and coenzyme A synthesis. This will allow a better understanding of the role of cysteine during redox adaptation in comparison to the well-known heme oxygenase 1 (HO-1). Secondly, I will disrupt key regulators of redox adaptation, including SLC7A11 and HO-1 to investigate their effect on macrophage functional phenotype. This will identify key nodes for redox adaptation in different macrophage activation states. Thirdly, I will investigate the temporal profile of electrophilic stress and redox adaptation in response to macrophage activation and during bacterial infection. Overall, this project will contribute to the detailed understanding of redox adaptation during macrophage activation, which is essential for pathogen defence and protection from oxidative stress. Furthermore, identification of new drug targets for redox regulation in macrophages would provide the basis for novel therapies for oxidative stress induced pathologies.


**Keywo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Electron and X-ray microscopy Community for structural and chemical Imaging Techniques for Earth materials', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Understanding earth materials is critical to creating a sustainable, carbon-neutral society due to their involvement in many vital processes. Earth materials control the feasibility of subsurface energy storage, geothermal energy extraction, and are a source of critical elements for future-proof battery technologies. However, perturbations to geological systems can also result in hazards, such as human-induced earthquakes. If we want to tackle the current, pressing scientific questions related to sustainable development for a circular economy, there is an urgent need to make multi-scale, multi-dimensional characterisations of earth materials available to a broad spectrum of earth-science disciplines. In addition to the society-relevant topics, the properties of earth materials determine how the Earth works on the most fundamental level.To overcome this challenge, 15 European facilities for electron and X-ray microscopy join forces to establish EXCITE (Electron and X-ray microscopy community for structural and chemical imaging techniques for earth materials). The collective aim of the EXCITE starting community is to enable access to high-end microscopy facilities and to join the knowledge and experience from the different institutions. By doing so, EXCITE will develop community-driven technological imaging advancements that will strengthen and extend the current implementation of leading-edge microscopy for earth-materials research. In particular, the EXCITE strategy is to integrate joint research programmes with networking, training, and trans-national access activities, to enable both academia and industry to answer critical questions in earth-materials science and technology. As such, EXCITE builds a community of highly qualified earth scientists, develops correlative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Science and Dogma: Tracing Natural Knowledge within Scholastic Theology (1545–1789)' (SCIGMA) targeting Horizon Europe.

assistant: **Abstract**

The early modern period is usually viewed as a time of profound change, including the so-called ‘Scientific Revolution’ and the Protestant/Catholic Reformation. Historians have linked these two seemingly disparate transformations in many different ways, but one important dimension is yet to be uncovered. SCIGMA’s main hypothesis is that natural knowledge significantly influenced dogmatics as a central branch of theology in the early modern university. University textbooks eagerly addressed many questions related to natural knowledge, such as: Can the bodily resurrection be understood from a physiological perspective? Which physics apply for the Eucharist? While much has been written on the impact of theology on the natural sciences, SCIGMA will turn the tables to uncover their truly entangled relationship. The project will systematically investigate how naturalism and empiricism informed scholastic and dogmatic theology, from the Council of Trent to the French Revolution across all Western Christian denominations. Its research agenda will consider theology as a ‘scientia’ in the premodern university and therefore include it within the history of science and knowledge.SCIGMA’s first goal is to discover the multiple and changing ways in which natural knowledge informed premodern scholastic theology, which sought a rational reconstruction of faith. Second, it will uncover what effective epistemological frameworks accommodated this interplay of empiricism and revelation. Third, it will trace how these epistemological frameworks were determined by their embedding within religious and secular institutions of learning. This complex historical analysis will reveal the significant role of the ‘physico-dogmatic domain’ in institutional learning. Thereby, it sheds novel light on h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fine Pitch / High Density Flex Interconnection' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

FLEXIL project deals with the development of highly integrated man-machine interfaces based on flex interconnection technology.Applications focused are:- large LCDs applied into the harsh environment of avionics (Airbus or automotive), that require high density connection to feed the power and the data to the LCD from the symbol generators and the power supplies,- very flat, integrated small displays for smart cards or portable electronics that require also low cost- high density flexes and high density assembly processes like flip chip on flex, and micro-packages surface mount on flex.FLEXIL project objective is to develop very advanced Flex based technologies and related innovative assembly processes to put European industry in a position to manufacture better flat panel displays and electronic integrated products for high end (avionics, automotive) and high volume applications (smart cards, telecom).Objectives:FLEXIL project objective is to develop very advanced Flex based technologies and related innovative assembly processes to put European industry in a position to manufacture better flat panel displays and electronic integrated products for high end (avionics, automotive) and high volume applications (smart cards, telecom).Particularly FLEXIL is focused on:- very fine pitch tapes (54 µm), and flex for flip chip (80 µm),- surface mount and anisotropic gluing processes,L%- reliability of the technologies developed for severe environments.Applications focused are:- large LCDs applied into the harsh environment of avionics (Airbus or automotive), that require high density connection to feed the power and the data to the LCD from the symbol generators and the power supplies,- very flat, integrated small displays for smart cards or portable electronics that require als
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Electronic Arbitration Tribunal: an Alternative Dispute Resolution for SMEs' in the context of a Fifth Framework call.

assistant: **Objectives**

E-Arbitration-T will provide a networked dispute resolution forum within the eCommerce community. It will analyse and define the technological requirements, the necessary infrastructure and the regulatory framework for establishing and co-ordinating an internationally-distributed Arbitration Tribunal using networked computers and intelligent multi-agent systems as their primary means of communication. The project will also deliver a validated agent architecture and concrete exploitation plans.OBJECTIVESThe main objective is to provide a networked dispute resolution forum with the same style and ease of access as exists between business partners within the eCommerce community. It will develop and validate the regulatory structure and the dynamic and intelligent infrastructure needed to allow simple and efficient distributed processes in electronic out-of-court dispute settlement systems.In particular: (i) to develop a deep analysis of arbitration processes in order to define the tasks that can have the highest degree of ubiquity and automatization; (ii) to guarantee a secure and reliable environment through which users may safely access the service through the Internet; (iii) to provide the legal framework for defining the activities, procedures, best practices and competence of the E-Arbitration. The E-Arbitration-T framework will be particularly targeted at the needs of SMEs.DESCRIPTION OF WORKThe E-Arbitration-T Project will analyse, define, pilot and validate the technological requirements, the necessary infrastructure and the regulatory framework for establishing and co-ordinating a seamless Arbitration Tribunal using networked computers as their primary means of communication. To establish the international legal framework the project needs to analyse existing solu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Collaborative signal processing for efficient wireless sensor networks' in the context of a Sixth Framework call.

assistant: **Objectives**

There has been great interest recently towards the development of Wireless Sensor Networks, whose goal is to monitor the physical world by means of densely distributed wireless nodes. It is envisioned that it will soon be feasible to deploy massive amounts of inexpensive devices to observe large ground surfaces, underwater regions, and areas in the atmosphere. These devices will be able to provide unprecedented opportunities for instrumenting and controlling the environment, our cities, both our microcosm and macrocosm.Networked microsensors is a key technology in various disciplines such as:- environmental monitoring, including wildlife habitat sensing and preservation, climate observation and prediction, seismic activity monitoring and impact;- industrial sensing, including factory and appliances management,- infrastructure integrity, comprising power grid and public construction control and command, and- education, art, and entertainment, enabling exciting virtual and immersive digital spaces.Realisation of large distributed sensor systems requires major advances in the theory and understanding of distributed data processing in highly uncertain environments with power, computation, and communication constraints. Hence, the fundamental scientific reason for conducting research in this field is to address problems including: adaptive collaborative processing in highly uncertain environments, consistent fusion algorithms for networked sensors, and representation and transmission of information in large and uncertain networks.Our goal is to address these challenges drawing on obtained experience in array and statistical non-Gaussian signal processing, adaptive systems, multiresolution signal and image denoising, compression, classification, communication theory, and imme