RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Environment friendly food production system: requirements for plant breeding and seed productionomental' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The most rigorous low-input system is the organic farming system as defined by EU directive 2092/91 where pesticides and synthetic fertilizers are generally not allowed and yield stability and quality have to be ensured by the cropping system itself. Often in low-input systems yields are highly variable and have varying quality, partly because the varieties grown have not been developed for this system and are therefore not optimal. An important means of stabilising crop yields and quality is, therefore, selection and evaluation of varieties and lines based on varieties characteristics of relevance for low-input production. Modern cereal varieties have been developed with the aim of combining high productivity and uniform product quality under high input conditions with pesticides, synthetic fertilizers and growth regulators, which also help to reduce environmental variation. This project will bring together the currently fragmented cereals research expertise with the EU in order to initiate emergence of strong transnational regional into an research network on cereals quality for food/feed production able to provide strong partnership to the colleagues in Baltic Sea region and EU. During this seminar plant breeders and seed producers of Baltic States as well as the partners from other countries with experience in organic agriculture will provide platform for discussion and exchange of knowledge and expertise between conventional and organic plant breeding and seed and food production. Representatives from each country will inform about the situation in each country in this area. Based on the results from national research and achievements to develop scientific concepts for breeding, a network among breeders, researchers, seed and food producers will be established. Suc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Somatic hypermutation of immunoglobulin genes' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Somatic hypermutation is, in part, responsible, for affinity maturation during an immune response. This process is highly regulated at both the cellular as well as at the molecular level. The frequency, distribution and nature of these mutations strongly suggest that the hypermutation process is not random. The underlying mechanism, however, has remained elusive.  Recently, lymphoid-specific enhancers have been shown to play a crucial rule in targetting the antibody V region (Betz et al., Cell 77, 239-248; Sharpe et al., EMBO J. 10, 2139-2145). Moreover, is has been demonstrated that the process exhibits specific base substitution preferences (Betz et al., PNAC, 90, 2385-2388) and is able to distinguish between the coding and noncoding strand. The aim of this project is to gain a better understanding of the regulation of the hypermutation machinery. For example, transgenic mice have been produced in Dr. Neuberger's laboratory to characterize the roles of enhancers. Using the above system I have already obtained interesting results (Nature, submitted). I will continue these studies as a PhD student starting October 1995.  The results will facilitate the establishing of an in vitro hypermutati system which could be used, for example, to produce mutant non-immunoglobulin proteins in vivo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Functional Calculus for Computational Statistics' (FunCalc4Stats) targeting Horizon Europe.

assistant: **Abstract**

Computations with spatial or spatiotemporal data occur in various areas such as the social and environmental sciences. The technological progress in data collection and storage capacities in recent years has caused a tremendous growth in data, and thereby exposed the limitations of state-of-the-art computational methods for statistical inference and predictions. Achieving computational feasibility severely limits the dependency structures of underlying random processes in currently deployed models. Above all, there is a strong need for methodologies that capture intricate spatial or spatiotemporal dependencies.This project seeks to characterize flexible dependency structures by means of functional calculus and to exploit this characterization for efficient computations with Gaussian processes. My overall aim consists of a systematic construction and approximation of covariance operators, corresponding to sophisticated nonlocal dependencies, via the action of functions on local linear differential operators.To establish numerical methods for operator functions, I will consider contour integral representations. Expedient transformations of the contours will facilitate operator-valued quadratures based on sinc approximations, which I will combine with uniformly stable discretizations for variational formulations of partial differential equations (PDEs) such as elliptic diffusion, parabolic and Stokes equations. To derive sharp rates of convergence, I will employ discrete inf-sup theory. Thereby I will address specific classes of functions and of differential operators suitable for inference from data. A particular focus will be on spatiotemporal statistical models based on fractional powers of non-autonomous parabolic operators, for which I will analyse space-time finite e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular basis of human enhanceropathies' (ENHPATHY) targeting Horizon 2020.

assistant: **Abstract**

Mutations within coding genes have traditionally been considered the major genetic cause of human disease. However, it is becoming increasingly clear that the genetic, structural and/or epigenetic disruption of enhancers and enhancer landscapes represent major etiological factors in numerous human diseases (i.e. enhanceropathies), ranging from rare congenital disorders to common diseases associated with ageing (e.g. cancer, diabetes). Although changes in enhancer activity are predicted to have broad pathological and therapeutic implications, we currently have a limited mechanistic understanding of human enhanceropathies. This reflects, at least partly, our still primitive and partial understanding of the mechanisms whereby enhancers can control gene expression. We hypothesize that enhancers are a diverse group of regulatory sequences that can utilize different mechanisms to control gene expression at the transcriptional and/or post-transcriptional level. Consequently, human enhanceropathies are likely to display an equally diverse molecular basis that, we believe, can only be uncovered using highly multidisciplinary systems biology approaches. Chiefly, elucidating the molecular basis of human enhanceropathies has far reaching translational implications, especially considering the pandemic proportions that some of these disorders are acquiring in recent years. Therefore, the major goal of the ENHPATHY network is to provide early-stage researchers with a multidisciplinary training in which cutting-edge genomic and genetic engineering approaches are  ombined with various in vitro and in vivo disease models. Moreover, together with our private partners we aim at translating our molecular findings into new diagnostic and therapeutic strategies.


**Keywords:** Enhancer, enha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'COllective action Models for Energy Transition and Social Innovation'.

assistant: **Concept**

There are large knowledge gaps around the governance of the low carbon energy system transition in a smooth and participative way, ensuring that citizens are at the centre of the required fundamental transformation and enabling the full efflorescence of their creative potential. Social innovation is a prime way to tap into that potential while Collective Action Initiatives (CAIs), a social innovation in itself, are a prime way to mobilize people and to ensure the acceptance for and participation in the necessary transition process. However, both social innovation and CAIs lack proper scientific and field-tested understanding of their development and factors for success. As of today, the role of citizen-driven CAIs (e.g. energy communities, cooperatives, purchasing groups) and their contribution to the energy transition has neither been quantified at an aggregate level, nor has their contribution potential been estimated or understood in sufficient depth. The COMETS project aims to fill these knowledge gaps by quantifying the European-wide aggregate contribution of CAIs to the energy transition at national and European levels by investigating their evolution and scaling up at an in-depth level in six selected countries. The main expected impacts of the project are two-fold. Firstly, COMETS will advance the scientific knowledge on the motives, desires, objectives and barriers of such collective action initiatives and their historical and future role in the energy transition. Building on the information gathered and tested for its robustness, we will then co-develop and test supportive tools together with CAI members, decision makers and the scientific community. Lastly, these stakeholders will then be able to exploit the main outputs of COMETS, namely a Supporting Platfor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Euroconference Bavar 2000, BAroreflex and cardiovascular VARiability supported by the European Commission, DGXII, Human Potential Programme, High-Level Scientific Conferences.'.

assistant: **Concept**

Hypertension and cardiovascular disorders are major health risk factors and significantly reduce life expectancy of the population in the countries of the European Union. Recently, the importance of blood pressure variability and arterial baroreceptor function has been recognised as important diagnostic markers and independent risk factors in circulatory disease, such as hypertension and myocardial infarction. Thus, a nucleus of experts specialised in the field of baroreceptors and variability have set out to spread the newest techniques for assessing these pivotal elements in the disease of heart and vessels (the so called BAroreceptors and VARiability).Baroreflex sensitivity can now be approximated by different analytical procedures. The methodology ranges from highly complex mathematical algorithms, over statistical assessment, down to simpler, but robust procedures such as the sequence method. The BAVAR 2000 meeting in Berlin brings together the nucleus of European investigators who have played the leading role in the development and advancement of these techniques. It is unique that we comprise a wide range of scientists from several different fields such as applied mathematics, engineers, biologists, and finally medical researchers and clinicians. Taken together, the scientific technological objectives of this meeting is to improve the assessment of bar receptor sensitivity using non-, or minimal, invasive techniques. Furthermore, the role of blood pressure variability for endorgan damage and the consequences of hypertension will be elucidated.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00038-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'SHAring Researchers’ Passion for Excellence and Results. European Reserarchers' Night in the Centre of Italy 2014 - 2015'.

assistant: **Innovation**

The SHARPER project (Sharing Researchers’ Passion for Excellence and Results - The European  Researchers’ Night in the Centre of Italy, 2014 – 2015) wants to make the researchers’ quest for excellence accessible to everybody in cities and communities where researchers act and live. Excellence is one of the main goal that researchers aim at through high level research projects that can generate innovative results. Enthusiasm, emotions and knowledge are the driving force leading researchers constantly to face new challenges. Making this process accessible means to share with people this quest for innovative results. SHARPER will take place on 26th of September 2014 and the 25th of September 2015 simultaneously in Perugia, Ancona and L’Aquila, the capital cities of three regions in the centre of Italy: Umbria, Marche and Abruzzo. The network of cities together with their Research Institutions and science communication teams provides a group of excellence at national and international level. Perugia combines its tradition as University city with the presence in the city of a fifteen years experienced team (Psiquadro) of science communicators with a European profile. In L’Aquila, The Laboratori Nazionali del Gran Sasso (LNGS), of  the Italian Institute for Nuclear Physics, the University and the GSSI (Gran Sasso Science Institute) provide examples of world leading researchers teams. The Università Politecnica of Ancona is a growing Institution in the field of technological applications of research. SHARPER will include: street labs, exhibitions, performances or other communication actions in venues plenty of symbolic and practical value for the future development of the cities and their future based on excellence and innovation. The SHARPER communication actions will engage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Safe organic vegetables and vegetable products by reducing risk factors and sources of fungal contaminants throughout the production chain: the carrot - alternaria model' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

European agriculture is confronted with a growing demand of consumers for organic vegetables. However, undesirable components such as mycotoxins, fungal poisons which can produce toxic syndromes in humans and animals, pose a challenge to the safety of organic vegetable products. The overall objective of this proposal is to develop strategies to ensure a safe organic food supply by developing detection . methods, anticipating mycotoxin risks, tracing the sources of contaminants in the food production chain, and eliminating the risk factors. The research will be done with the model carrot-Alternaria, the latter fungus being a known producer of harmful myctoxins. This will result in safe organic carrots and processed products, thereby contributing to consumers health and supporting organic farming systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Tracing the FLUX of cosmic dust arriving to Earth during the Phanerozoic' (FLUX), addressing dissemination and exploitation.

assistant: **Impact**

For the last 4.5 billion years, extraterrestrial (ET) materials have continuously bombarded the Earth. Today, the Solar System debris that reaches the Earth’s surface is dominated by particles less than 2 mm in size, termed micrometeorites (MMs). Until recently, the established misconception was that these MMs did not survive geological timescales, limiting reconstructions of the dust flux through time that are currently based on finding rare relict mineral phases or applying geochemical tools (e.g., Ir contents, 3He isotope ratios). Following a successful proof-of-concept study on a Late Devonian section, FLUX proposes first to extract fossil MMs from selected stratigraphic intervals across the Phanerozoic to document their characteristics and origin and second to use them as a novel high-resolution proxy to better understand the dynamical interactions between the Solar System and Earth. As such, fossil MMs may serve as an alternative new source of information on Solar System processes, complementary to classic meteorites. By combining expertise in meteoritics, geochemistry, and chemostratigraphy, FLUX addresses the following questions: 1) How did the flux of cosmic dust evolve during the Phanerozoic? 2) Can stratigraphic intervals marked by a dramatic increase in the mass of cosmic dust accreting to the Earth be identified? 3) Do increased ET flux events reflect asteroid family-forming events in the asteroid belt between Mars and Jupiter, and are they influenced by changes in the shape of Earth’s orbit? 4) Can oxidized iron-rich MMs be used to reconstruct the gross primary productivity or atmospheric CO2 levels of the deep past? 5) Did ET flux fluctuations affect the global Earth environment, for example through ocean fertilization? Ultimately, FLUX will better positi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dendrites and memory: role of dendritic spikes in information coding by hippocampal CA3 pyramidal neurons' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The hippocampus is essential for building episodic memories. Coding of locations, contexts or events in the hippocampus is based on the correlated activity of neuronal ensembles; however, the mechanisms promoting the recruitment of individual neurons into information-coding ensembles are poorly understood.In particular, the recurrent synaptic network of pyramidal cells (PCs) in the hippocampal CA3 area, receiving external inputs from the entorhinal cortex and the dentate gyrus, is thought to be essential for associative memory. Current models of the associative functions of CA3 are mainly based on plasticity of these synaptic connections. Recent work by us and others however suggests that active, voltage-dependent properties of CA3PC dendrites may also promote ensemble functions. Dendritic voltage-dependent ion channels allow nonlinear amplification of spatiotemporally correlated synaptic inputs (such as those produced by ensemble activity) and can even generate local dendritic spikes, which may elicit specific action potential patterns and induce synaptic plasticity. Furthermore, dendritic processing may be modulated by activity-dependent regulation of dendritic ion channels. However, still little is known about the active properties of CA3PC dendrites and their functions during spatial coding or memory tasks.The general aim of my research program is to understand the cellular mechanisms that underlie the formation of hippocampal memory-coding neuronal ensembles. Specifically, we will test the hypothesis that active input integration by dendrites of individual CA3PCs plays an important role in their recruitment into specific context-coding ensembles. By combining in vitro (patch-clamp electrophysiology and two-photon (2P) microscopy in slices) and in vivo (2P imaging a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Marine microalgae-based functional foods and food supplements for the prevention of chronic diseases' (TetraFOOD).

assistant: **Concept**

FITOPLANCTON MARINO S.L. (FM) is one of the European leading companies in marine microalgae production and is the first microalgae production company in achieving the European Novel Food approval for the marine microalgae species Tetraselmis chuii. The company, currently involved in microalgae production for aquaculture, cosmetics and human nutrition, aims to position itself as a leading company in the production of high-value bioactive compounds for the food sector.Building on the results of previous research work conducted by the company, FM aims to use T. chuii as a natural biofactory for the production of high value bioactive compounds with potential to improve health and reduce the risk of chronic diseases. FM will commercialise a food supplement based on whole microalgae T. chuii and an innovative extract rich in bioactive compounds to be used as functional food ingredient. Currently, no commercial product based on T. chuii is available in the market. Potential clients are nearly 170 companies currently involved in the elaboration of functional foods, and potential end-users include general consumers willing to prevent health issues and men and women suffering from health risk factors influenced by diet.The feasibility assessment is structured in three main components: a) detailed market analysis; b) feasibility assessments at the economic & financial, technical and legal & regulatory levels; and c) elaboration of a Business Innovation Plan II setting the strategies (in terms of product development, commercialisation, financing, management of IP rights,...) to bring the marine microalgae-based products to industrial readiness for market uptake.The project will permit to provide European consumers with new innovative functional ingredients and food supplements with