RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Role of BDNF and BDNF-related genes in animal models of neuropsychiatric disorders' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Brain-derived neurotrophic factor (BDNF) has been initially regarded as a growth factor, but a broader function is suggested by the observation that BDNF is anterogradly transported, released in an activity-dependent manner, and elicits rapid synaptic responses. The host laboratory has demonstrated that BDNF controls the expression of the dopamine D3 receptor (D3R) that various pharmacological and neuro-anatomical data have suggested to be implicated in drug addiction, Parkinson's disease and schizophrenia. Moreover, BDNF-dependent up-regulation of the D3R triggers behavioural sensitisation, a cardinal process in compulsive drug consumption in drug addicts, in dyskinesia in patients with Parkinson's disease, and in psychotic symptoms exacerbation in schizophrenia.The objective of this proposal is to define and characterize the functions of BDNF as an extra-cellular transmitter. For this, we will characterize BDNF-regulated genes, which, like the D3R gene, may be important for the three disorders, by exploiting data of using high-throughput transcriptome analysis with DNA micro-arrays and design a selective BDNF antagonist. We will also engineer transgenic mice over-expressing BDNF in selected neurons to mimic BDNF over-expression that we observed in animal models of drug addiction, Parkinson's disease and schizophrenia.The major possible outcomes of this project are likely to enhance our understanding of the pathophysiology of drug addiction, Parkinson's disease and schizophrenia and provide new therapeutic approaches. For this scientific programme, an IRG is requested for reintegration in Europe of an experienced female researcher, initially trained in France, then for 6 years in the US, where she was nominated Research Assistant Professor and developed various experim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'VARIFN: Understanding variation in the type I interferon response and its impact on infection susceptibility in humans.'.

assistant: **Innovation**

Both antiviral immunity and susceptibility to viral infections are remarkably variable. Factors such as older age, increased body mass index, and male sex can increase the risk of developing severe viral disease, yet the impact of these features on antiviral immunity, particularly the type I interferon system (IFN-I), is not understood. Here we propose to use a systems immunology approach to identify features that influence IFN-I responses and understand their impact on infection susceptibility. We will use datasets and samples from the Milieu Interieur (MI) cohort of 1000 donors consisting 500 males and 500 females aged 20-69 years old. Using Simoa digital ELISAs, we have quantified IFN-I (IFNa and IFNb) in the supernatants of whole blood from the 1000 donors that was stimulated ex vivo with 7 agonists that activate the IFN-I system. Preliminary analysis of these results shows interesting age and sex differences in the IFN-I response. We will integrate the IFN-I cytokine data with existing demographic, microbiome, immune cell phenotyping and plasma protein data from the cohort and determine their associations with IFN-I levels. To investigate sex differences in IFN-I we will quantify sex hormones in the plasma of the 1000 donors. We will perform RNA-sequencing on IFNa-stimulated whole blood on a subset (n=200) of the donors to investigate the factors that shape the response to IFNa itself. We will perform genome wide association studies of the IFN-I response in the cohort to identify variants that influence IFN-I production using SNP genotyping data from MI. To determine the impact of these features on IFN-I and influenza infectivity in vitro, we will develop an organ on chip model encompassing features that we find to be associated with IFN-I levels in MI. Results fro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Circuits ultimate miniaturisation utilising multi-layer build up substrates' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Components: Usage of flip chip with pitch down to 150 um or with redistributed pitch down to 250 um as well as Chip Scale or Chip Size Packages (CSP), peripheral pitch down to 200 um or grid array pitch down to 300 um.First level interconnect: Mounting onto filled and tented vias. Reflow soldering for fine pitch flip chip, combined with underfill. Flip chip and SMD on flexible substrates combined using adhesive technology. Substrates: Fine line multilayer substrates with lines and spacing down to 50 um, both in rigid and flex form with via in pad technology realised by photo imaging or laser drilling.Second level interconnect: Interconnect to the outer world, through a moulded injection device ( MID).The Multi-Chip Module (MCM) technology will be made more attractive for use in communications, automotive, industrial and consumer electronics applications.This will be realised by the development of a highly miniaturised and low overall cost MCM technology. It comprises innovative and low cost production processes at all levels- components, first level interconnect, substrates, second level interconnect- of the MCM architecture. The goals can be achieved through :
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development and field testing of a compact HTS hydro power generator with reduced investment costs, lowered environmental impacts and strongly improved performance to reduce the price per KWh' (HYDROGENIE) under Sixth Framework.

assistant: **Objectives**

Hydropower is the largest and most mature source of renewable energy. Hydropower is also sustainable energy 'par excellence'. It replaces fossil energy production and protects nature and society from many harmful emissions such as greenhouse gases and sulp hur dioxide which have the worst environmental impact. These environmental advantages already led the European Commission to a strong commitment to support the development of hydropower. High Temperature Superconductors (HTS) combine nearly loss-less flow of electricity with extremely high current densities, when combined with viable refrigeration. Thus, enabling most compact and highly efficient rotating machinery. In the European Union alone, hydropower contributes to the production of about 19% of electr icity. Already now hydropower is averting thereby the emission of some 76 million tonnes of CO2 annually. Since generators based on HTS technology can deliver energy at a considerably higher efficiency (+7%), 15.4 GW could easily be produced for free" on the global scale without any environmental impact. This would be equivalent to roughly 40 conventional power stations that can be deferred due to the use of efficient HTS technology - a significant contribution to the Kyoto-protocol targets. The combinatio n of these two key technologies, HTS power generation and hydropower as such has not been addressed before, despite its large potential. The target of HYDROGENIE is to develop and field test a compact HTS hydropower generator with reduced investment costs, lowered environmental impacts and strongly improved performance to reduce the price per kWhby10%. Key merits of HYDROGENIE include - Reduced investment cost on the generator - Reduced price per kWh for power generation - More energy produced by the same w ater
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'From Dark Matter to the Large Hadron Collider: A New Data-Driven Era' in the context of a Seventh Framework call.

assistant: **Objectives**

The upcoming years are poised to be exciting. The frontiers of particle physics will expand as new data from high energy colliders, astrophysical measurements and Dark Matter (DM) direct detection experiments become available. After more than 40 years dominated by the Standard Model (SM) of particle physics, it is likely that soon the way will be paved to an extended, more profound theory of Nature.  This proposal investigates several aspects of theories beyond the SM, collider phenomenology and DM physics, emphasizing the interplay between the subjects, and following closely the experimental results.  One emphasis is  placed on DM and in particular on paradigms that go beyond the vanilla Weakly Interacting Massive Particle (WIMP) scenario.  Specifically, we propose to study the theoretical motivations and experimental avenues to detect the largely unexplored light DM paradigm.  Another natural focus of attention is the Large Hadron Collider (LHC).   We propose to study low scale hidden sectors and their collider consequences.  In particular, we focus on related non-standard Higgs decays that require dedicated searches to discover.  In this new era, theorists must ensure they are prepared to interpret, correlate, and refine their understanding of nature, as new data flows in from the myriad of ongoing experiments. This is the spirit of the proposal at hand.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Backscattering coherent Stokes Raman scattering (sCiSsoRS) for real-time cancer diagnostics' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

The gold-standard for cancer diagnosis is the pathological examination of Hematoxylin & Eosin (HE) stained tissue. Though well adopted worldwide for the coloration of large numbers of cancer sections, the classical HE-staining procedure is unable to provide a fast-feedback to surgeons within less than 30min. This latency compromises the efficiency and accuracy of any tumor resection with numerous negative impacts for the success of the surgery and patients health prospect. Recently, the chemical-bond-specific image contrast provided by stimulated Raman scattering (SRS) was shown to be suitable for the generation of HE-like images. However, the SRS signal fundamentally propagates forward and is absorbed in thick biopsies rending a SRS-based diagnosis impossible. Furthermore, the SRS imaging speed is still too slow for the real-time determination of cancer borders in large specimen.Here, I want to resolve these obstacles by combining the non-linear optical contrast Coherent Stokes Raman Scattering (CSRS) with high illumination angles. CSRS will permit for the HE-like image generation, but will direct the signal photons into the backward direction as a result of a unique momentum conservation law. Backward CSRS will allow for the investigation of thick cancer samples and will enable technical solutions to boost the imaging speed that were never an option before.  Thus, the development of CSRS is not only a scientific breakthrough that circumvents the fundamental dogma of always forward scattered light but will provide HE-like images of thick samples as a real-time feedback to improve the success rate and time-efficiency of cancer surgery.


**Keywords:** Coherent Raman spectroscopy, coherent Raman Histology, wide-field coherent Raman microscopy, non-linear multi-focus micr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Renovation of Residential urban spaces: Towards nearly zero energy CITIES' (R2CITIES) targeting Seventh Framework.

assistant: **Abstract**

R2CITIES aims to develop and demonstrate an open and easily replicable strategy for designing, constructing, and managing large scale district renovation projects for achieving nearly zero energy cities. For this purpose, it will be developed a demonstration and dissemination framework of very innovative strategies and solutions for building energy renovation at district level, based in the following pillars:• Three demonstrations of residential district retrofitting, in different countries, climate conditions, user’s habits, etc.• A very ambitious dissemination programme focused on public and professional audiences.• Several studies of cost-effective solutions for the holistic improvement of the energy performance of buildings at district level (definition of standard indicators and new diagnosis approach, analysis of existing energy technologies in a systemic approach, new strategies for urban energy planning, …)•Deployment of a rigorous measurement and verification of energy performance and savings plan for each demonstration, taking into account standard protocols as IPMVP.•A market and replication deployment plan, in order to ensure the project impact at business level, and a results exploitation strategy suitable for achieve a wide impact.3 demo sites will be addressed for demonstrating the framework and associated impacts by developing real cases going beyond current market standards but ensuring the replicability of the concepts deployed. R2CITIES makes a difference from current state of the art, as it will be far away from current expensive and stand alone pilots that have failed into reaching the market. Valladolid, Genoa and Kartal (Itanbul) municipalities will provide three demo sites for a very ambitious renovation of three residential districts, involving
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Low-dose breast CT with monochromatic x-ray sources', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Although breast cancer screening and improvements in treatment have reduced breast cancer mortality by 30%, this disease still kills over 600,000 women yearly worldwide. To further reduce its morbidity and mortality, new and improved imaging modalities that improve the detection, diagnosis, and treatment of breast cancer are needed.Over the last two decades, changes in x-ray detector technology have revolutionized x-ray-based breast imaging. Among other developments, new digital detectors made feasible the ERC Consolidator project BREAST4D during which a new imaging modality, dynamic contrast enhanced dedicated breast computed tomography (4D DCE-BCT) is being developed to personalize treatment of breast cancer.However, x-ray source technology has remained essentially unchanged for the last 100 years. The continued use of the x-ray tube as the source of x rays restricts the reduction in dose and the quantitative accuracy achievable with advances in the rest of the system. Very recently, however, a new monochromatic x-ray source has been developed that provides the necessary flux, x-ray energy, field of view, and portability, to be used in x-ray breast imaging devices.In MONOBREAST, the capabilities, applicability, and innovativeness of BREAST4D will be extended by introducing these monochromatic x-ray sources to breast CT imaging and combining them with the advanced image reconstruction method developed during BREAST4D. Resulting in a dose reduction of at least two thirds, such a monochromatic breast CT system will be applicable to every stage in the breast cancer chain, from screening with non-contrast BCT at doses equivalent to those of current screening with digital mammography and digital breast tomosynthesis, to static CE-BCT for diagnosis and the originally planned
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Carotid-artery-on-a-chip device to model thromboembolisms induced by vascular lesions and perform drug screenings' (CAR-OAC).

assistant: **Concept**

This project will be focused on designing a microfluidic device to visualize haemodynamics within a carotid-artery mimetic device. The system will be designed to evaluate associations especially between fibrinogen, erythrocytes, and platelets when subjected to shear and coagulation-inducing factors. The design will include biologically and mechanically variable properties as may occur in transient ischaemic attacks (TIA). The intended system is to have similar composition and dimensions as the extra-cranial (common to internal) carotid arteries. Physiologically relevant dimensions will be implemented where the common artery will have a lumen diameter of 6.1 mm with variable thickness (0.6 to 0.9 mm), whereas the internal artery will be 4.7 mm in diameter with thickness of 0.7mm. The system will be equipped with pressure and stretch-inducing mechanics which can be modulated to trigger rheological and biological responses. Specifically, stretching will cause exposure of tissue factor and lipids, capable of triggering inflammatory coagulation. The proximal formation of biological or physical occlusions will be assessed using this device. Also, the design will enable visualization of intra-vascular activity as may be illustrated in live high-resolution confocal microscopy. Flow properties of liquids with varied rheological properties similar to blood will be tested. Clinicians and researchers studying the pathology of strokes and TIAs or conducting studies on intravascular thrombosis will be able to engage this device in experiments while pharmaceutical developers will be able to engage the device in testing actions of therapeutic agents.Stroke remains the second leading cause of death globally and through the development of this device, both developers and potential users
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'nanoVAST: a novel, non- viral LNP for precision payload delivery of genome editors and other cargo' in the context of a Horizon Europe call.

assistant: **Objectives**

Cell-specific cargo delivery is a key remaining problem in the field of RNA-based therapeutics. Thus far, delivery has relied on lipid nanoparticles (LNPs) which encapsulate RNA with high efficiency, but broadly lack in specificity. Viral vectors are currently the only FDA approved tissue-specific cargo delivery option, with specificity being the result of manipulation of outer capsid proteins. However, viral systems are also associated with drawbacks such as oncogenicity, antigenicity and pre-existing immunity to the viral carrier itself. The ideal carrier system would involve LNP-efficient cargo encapsulation together with specific targeting in the absence of oncogenicity or immunogenicity.      DKFZ and Panosome GmbH have together developed this exact particle – the nanoVAST: a patented vesicular phospholipid bilayer densely decorated with a single protein that can be fused to a targeting molecule of interest through specific, efficient, and separately patented chemistry. Importantly, the attachment of the targeting component relies on a coupling of the vesicle to the targeting moiety, rather than a genetic manipulation of the carrier itself (as is the case with viral vectors), giving this system an unparalleled level of versatility. Additionally, our vesicular system is inherently fusogenic with target membranes, thus permitting cargo delivery directly to the cytoplasm and avoiding the reliance on the incredibly inefficient “endosomal escape” mechanism that plagues LNPs (it is estimated that conventional LNPs only deliver approximately 1% or less of their payload into the cytoplasm).     This ERC PoC proposes to use the nanoVAST particle to (a) deliver specific RNA cargo to CD19+ B cells; (b) transport within the cells this cargo to the endogenous RNA editing machin