RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European vlbi network via the joint institute for vlbi in europe' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Description:In Europe most VLBI observations are carried out by the European VLBI Network (EVN), formed in 1980 by a consortium of five of the major radio astronomy institutes in Europe (the European Consortium for VLBI). Since 1980, the EVN and the Consortium has grown to include 9 institutes with 12 telescopes in 8 EU countries as well as associated institutes with telescopes in Poland, Russia, Ukraine and China. Together, the EVN telescopes form a large, distributed research infrastructure: a continent-wide radio telescope. The combination of simultaneous observations made by a widespread network of radio telescopes (interferometry) generates images of cosmic radio sources with a detail which would otherwise only be achievable by a hypothetical single telescope of continental dimensions. The Joint Institute for VLBI in Europe (JIVE) was established in 1993 to support and coordinate network operations from a central location. JIVE operates a 16-station VLBI Data Processor and provides extensive support to EU researchers.Application:An EVN Call for Proposals" is issued three times a year. Interested researchers wishing to use the facility are invited to submit a scientific proposal to the EVN Programme Committee - a User Selection Panel that peer reviews proposalsand awards and schedules observing time on the EVN. The "Call for Proposals" isadvertised in the European Astronomical Society Newsletter and widely-circulated to astronomical institutes within Europe and beyond. This call is also distributed via the internet, in particular through the world wide web and targeted e-mail exploders.Project Manager:Michael Garrett, The European VLBI Network of Radio Telescopes & JIVEEVN Support group, Oude Hoogeveensedijk 4, Dwingeloo 7990 AA, P.O. BOX 2, The NetherlandsTel: +31-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Mont-Blanc 2020, European scalable, modular and power efficient HPC processor'.

assistant: **Concept**

The Mont-Blanc 2020 (MB2020) project ambitions to initiate the development of a future low-power European processor for Exascale. MB2020 lays the foundation for a European consortium aiming at delivering a processor with great energy efficiency for HPC and server workloads.  A first generation product is scheduled in the 2020 time frame.Our target is to reach exascale-level power efficiency (50 Gflops/Watt at processor level) with a second generation planned for 2022. Therefore, we will, within MB2020: 1. define a low-power System-on-Chip (SoC) implementation targeting Exascale, with built-in security and reliability features;2. introduce strong innovations to improve efficiency with real-life applications and to outperform competition (vector instruction implementation, memory latency and bandwidth, power management, 2.5D integration);3. develop key modules (IPs) needed for this implementation; 4. provide a working prototype demonstrating MB2020 key components and system level simulations, with a co-design approach based on real-life applications;5. explore the reuse of these building blocks to serve other markets than HPC. Our key choices are:a) To use the ARM ISA (Instruction Set Architecture) because its has strong technological relevance and it offers a dynamic ecosystem, which is needed to deliver the system software and applications mandatory for successful market acceptance. b) To design, implement or leverage new technologies (Scalable Vector Extension, NoC, High Bandwidth Memory, Power Management, …) as well as innovative packaging technologies to improve the versatility, performance, power efficiency, reliability, and security of the processor.c) To improve on the economic sustainability of processor development through a modular design that allows to retarge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enabling advances in diagnosis, patient stratification and treatment for dilated cardiomyopathy patients and families.' (DCM-NEXT).

assistant: **Concept**

Dilated Cardiomyopathy (DCM) is a heart muscle disorder characterised by thinning and stretching of the heart ventricles, making it harder for the heart to pump blood (systolic dysfunction). This disorder, with an estimated prevalence of up to 1/250, predominantly affects younger adults. It is associated with significant morbidity and mortality, including heart failure and sudden cardiac death, with end-stage DCM being the leading indication for heart transplantation.The current disease burden in DCM is largely attributable to two important gaps in scientific knowledge: Firstly, our understanding of the aetiology and genetic architecture of DCM remains limited, hindering the utility of genetic testing in clinical patient management. Secondly, there are limited therapeutic options for DCM patients. Existing therapies are generic and target symptoms. No curative treatments exist, apart from invasive heart transplantation and there are no approved therapies targeting underlying molecular disease mechanisms. A fuller understanding of the genetic architecture of DCM and knowledge of the genes and genetic variants involved are critically needed to provide solutions for these unmet medical needs.The DCM-NEXT consortium combines world-leading interdisciplinary expertise and resources of 8 investigators in the fields of DCM, deep clinical phenotyping, cardiogenomics, cardiac transcriptomics, artificial intelligence, in silico drug target discovery and functional studies. They will uniquely leverage their unparalleled cohort of 11,750 DCM probands and relatives with extensive clinical and omics data.Through cutting-edge genomic and cardiac transcriptomic studies, the project aims to (1) revolutionise genetic testing and patient stratification for more precise prediction of diseas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'MediaRoad – European Media Ecosystem for Innovation' (MediaRoad) under Horizon 2020.

assistant: **Objectives**

The European audiovisual and radio sector has long led the world in its collaborative development of technology, standards and content. Due to media convergence and global competition, media organizations now face challenges from disruptive technology and business models. New policy agendas require their proactive and coordinated attention.Despite these challenges, EU media players have many advantages: they produce much of the quality content shared on social media, invest heavily in R&D, and are well placed to launch dynamic collaborative innovations.To further this substantial legacy, a consortium of public and commercial broadcasters, creative producers and research bodies now proposes to launch MediaRoad, a highly innovative coordination project with three interconnected Hubs:- The Sandbox Hub will enable media organizations to create a series of interlinked incubators, or Sandboxes, where SMEs can test and scale innovative concepts in operational environments. Each Sandbox will offer workspace, infrastructure and internal support for short periods. The Hub will create a toolkit, support Sandbox launches, and attract startups.- The Policy Hub will develop a policy vision for the whole radio and AV sector on topics such as the EU research agenda, data, 5G, security, immersive media, investment, training and regulatory issues. It will hold workshops, share updates, draft vision documents and link to other research projects.- The Network Hub will create a series of events to bring together broadcasters, researchers, content creators, technologists and entrepreneurs to inspire collaborations and share knowledge. Topics will include social media, post-convergence radio, multi-platform content, new audience measurements and robot journalism.MediaRoad will turn EU diversi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High resolution diode laser carbon dioxide environmental monitor' (1994-1998).

assistant: **Concept**

To develop a new instrument for measuring atmospheric CO2 based on diode laser absorption spectroscopy. Carbon dioxide is a very well known gas, and its importance for greenhouse effect is well established. All  around the world there is a network of measurement points (GAW, Global Atmospheric Watch of the World  Meteorological Organization) in order to measure its change in the local or in the global scale. In Italy the two  stations in this network are on the Cimone Mountain (owned by the Air Force) and at the Lampedusa Island  (belonging to ENEA). The Italian National Electricity Committee owns a further station at Plateau Rosa. In  Germany there are several stations belonging to the Umweltbundesamt and three other ones are in the area of  Garmish-Partenkirchen (Garmish-Partenkirchen itself, Wank Peak and Zugspitze). The knowledge of the exact  value of CO2 concentration in the atmosphere is fundamental for the determination of the actual contribution  of this gas to greenhouse effect and to give an estimation of the future trend. The average concentration of CO2  (referred to dry air) is about 350 ppm, and for an isolated station the range of variation is at most 345-375 ppm.  Higher values are obtained nearby woods, towns or plants. Moreover, the seas have a buffer effect on CO2.  A percentage in the range 20-50% of CO2 produced by burning fossil fuels is estimated to be absorbed by the  oceans. The uncertainty in this value is due to the lack of knowledge of the mechanism of exchange of CO2 at  the water surface. Performing CO2 measurement for climatological studies requires precise, fast and water  vapour insensitive instruments. The only kind of instrument presently used in this field is based on the  absorption of infrared radiation by carbon dioxide. Measureme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Improvement of quality and productivity for rolled and extruded aluminium products through microstructure and texture modelling' (1994-1998).

assistant: **Innovation**

Software code for the modelling of deformation texture developmentSoftware code for the modelling of flow stressSoftware code for the modelling of recrystallizationEvaluation of a set of different methodes for microstructure characterisation and the determination of the response in the microstructure to external factorsEvaluation and benchmarking of a set of different test methodes for the mesurement of flow stress.Verification of the models through application to industrial processes and products.This project aims to improve the quality of semi finished aluminium products by optimising the thermomechanical processing schedules involved in hot rolling and extrusion. A large number of alloy products destined for the building and packaging industries are subject to increasing international competition impelling the European producers to upgrade quality and to achieve higher productivity Thermomechanical processing, in particular controlled hot working, is the most cost effective method of achieving these objectives, but the complex strain paths encountered in hot rolling and extrusion preclude empirical optimisation. The primary objectives of this project are (i) to quantify the effects of deformation parameters (e, g, T) and shear on the development of microstructure and textures and (ii) to develop physically based computer models for practical use by the engineer in hot thermomechanical processing of industriai alloys. Current industrial problems concern grain structure and texture control for hot rolled sheet and extrusion speed, surface grain size and texture for extruded sections. The physically based model will focus on microstructure, grain size and texture evolution during hot working and subsequent annealing and will be the first of its kind for thermomechanical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biosensors based on membrane organisation to replace animal testing' to be submitted under Sixth Framework.

assistant: **Abstract**

The ultimate goal is the development and validation of alternative techniques to replace animal testing in procedures concerning drug screening and environmental control. The first step is the organisation of a Specific Support Action that brings together fragmented industrial and academic research groups in a Strategic Meeting. In this meeting a powerful platform in biophysical chemistry and biosensor technology will be formed. A prospective analysis will be outlined for future developments of membrane-based biosensors validated by comprehensive inter-calibration techniques. A Work Programme consisting of a set of Work Packages will be produced, with the aims to channel the original research into useful economic and society benefits, which will support the Amsterdam Protocol on animal protection and welfare, 1986. The Directive states in Article 7: An experiment shall not be performed if another scientifically satisfactory method of obtaining the result sought, not entailing the use of an animal, is reasonably and practicably available. Almost 17 years have elapsed since the Amsterdam Protocol was written and since that time research on supported lipid membranes has become increasingly intense. Highly selective biomimetic membranes are now available for biosensing applications in general and for replacement of animal testing in particular. This will increase the options of meeting the requirements in Article 7 above and even carry them further. The participating research groups from Europe, Israel and USA, are centres of excellence in membrane and peptide production, biosensing, physicochemical modelling, surface characterisation, polymer technologies, bioassay techniques and multivariate calibration. The participating industries represent leading pharmaceutical and ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A virtual cervical spine mechanism for biofidelic generation of intervertebral motion for testbed and educational purposes' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content The goal of the project is to design, build and validate a six-degree-of-f_edom mechanism for biofidelic test-bed simulation of inter-vertebral motion, employing standard six-degree-offreedom parallel platform design and control techniques. Hereby, loads and deformations are to be generated by a set of pneumatic legs joining the lower (caudal) vertebra (the 'base') with the upper (cephalic) vertebra (the 'platform'), respectively. Forces at the legs are computed by a suitable feed back control law determining pneumatic cylinder chamber pressures as a function of position of the platform and biologic parameters. As a result, a virtual cervical spine mechanism is produced that, although built differently than the natural spine, behaves physically in the same way, i.e., yielding the same stiffness properties as the real system. This makes it possible to adapt the mechanism behaviour to different test objects and load situations, allowing the analyst (physician, medical researcher, surgeon, or biomechanics engineer) to assess effects of therapeutic or surgical treatment prior to its application to the patient. Moreover, it may serve as a powerful tool for educational purposes, and as a highresolution test apparatus for in vitro accurate measuring of biological parameters of spinal units under controlled motion/load conditions. Training content (objective, benefit and expected impact) The expected training benefit would be in the areas of (1) biomechanics, (2) mechanism design, (3) optimisation, (4) advanced multibody simulation, (5) object-oriented programming, and (6) control of mechatronic systems. Additionally, the creation of the targeted virtual cervical spine mechanism would endow physicians and educational instructors with a powerful t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of dynamic microtubule in the structure and function of dendritic spines' (DYNAMICMTINSPINES).

assistant: **Concept**

Synaptic connections within the adult brain are not fixed and stable but remarkably flexible. This reorganisation of synaptic connectivity is a basic principle of neuronal plasticity and believed to represent the cellular basis for learning and memory function. Dendritic spines form the dynamic postsynaptic component of most excitatory synapses in the brain. Recent studies from the host laboratory revealed the invasion of microtubules (MT) into dendritic spines. Several lines of evidence indicate that synaptic activation increases MT entry in spines. However, it remains unclear how synaptic signals trigger intraspinal MTs and what is the effect of MT invasion for spine structure and function.The proposed project is aimed to investigate the functional consequences of dynamic microtubules in spine plasticity. We will combine molecular biology, organotypic slice cultures, quantitative/high resolution microscopy, and electrophysiology to investigate the role of MT based mechanisms in synaptic plasticity. In this application we propose to: Objective 1. Characterise synaptic signals that control MT spine entry. We will analysis different neuronal activation patterns as potential triggers of MT spine invasions. Objective 2. Determine the role of MT spine entry for structural spine plasticity. Functionally, dynamic MTs can contribute to dendritic spine plasticity by regulating intraspinal actin dynamics or cargo transport into spines. We will test whether MT entry stabilize/modify the invaded spine in slice cultures and analyse the role of dynamic MT in the development of immature dendritic protrusions. Objective 3. Examine the role of dynamic MT for cargo trafficking into spines. The role of dynamic MT for transport of cargo into spines will be studied by analysing kinesin/dyn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mixing Ionic Liquids' (MIL) under Seventh Framework.

assistant: **Objectives**

This proposal is will open a new field of study: Using ionic liquid mixtures to provide optimal solvent systems for chemical synthesis. It is challenging and has input from a wide range of techniques, from theory, physical property measurement to measuring effects on the rates of reactions. It will generate both fundamental understanding of the behaviours of ions in mixtures and the ability to manipulate these behaviours for process development and scale-up. This will enable these exciting new systems to be applied on the industrial scale. The potential impact of the capability building represented by this programme spreads across the chemicals industry and on to society in general through more efficient, greener chemicals processing and the consequent reduction of negative environmental impacts. During the last decade ionic liquids have transformed from interesting, but poorly known materials to the subjects of huge research activity for both academic and industrial chemists. European academics and companies have been in the forefront of the application of ionic liquids. This proposal will be an important contribution to maintaining that lead.  Ionic liquids are  designer solvents  that can be fine-tuned to be the optimum solvent for applications This project will provide a step-change in the synthetic flexibility available for ionic liquid properties  design by making mixtures of ionic liquids.  This is an entirely new approach and there is little information that can be used to make predictions. However, we know from our knowledge of molecular mixtures, molecular/ionic mixtures and mixtures of high melting salts, that the behaviours to be seen are likely to be complex and non-linear. This will provide opportunities to tune different properties independently to provid