RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Extending On-Demand wheel Drive to On-Road applications' to be submitted under Horizon 2020.

assistant: **Abstract**

Today sectors like agriculture, forestry, transport, mining and construction require heavy duty vehicles that must outperform in highly demanding off-road conditions such as slope climbing and/or wet/slippery terrain. All while hauling or pulling large dead weight and facing obstacles bound to appear in un-paved roads. When performing these works, failure of the tractor to provide pulling force to the wheels leads to the convoy getting stuck. The solution is not a  more powerful engine in the tractor head, the most efficient solution is to apply high torque at low speeds directly to the wheels.  Black Bruin has developed the most efficient On-Demand wheel Drive solution, based on the integration of a unique wheel motor design. The result is an ODD system that can be integrated in trailers to power wheels, delivering traction force where is most needed, i.e. under the cargo. In this way, total power reduction of 30% and 20% fuel savings can be achieved, while increasing vehicle off-road / on-road use flexibility.  Black Bruin is today’s third hydraulic LSHT motor supplier worldwide after giants like Bosch Rexroth and Poclain. We are a nearly 100-employee company, where 70% are employed in the manufacturing area and 30% in our offices. We count with a powerful portfolio of suppliers, research and academic institutions, consultants and engineering firms supporting our internal team.  The new E-ODD system will allow us to move from a 15 M€ company to a 35 M€ company by dramatically extending the range of vehicle applications our product can be suited for.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Metabolic Reprogramming by Induction of Transcription'.

assistant: **Objectives**

Plants continually monitor the environment to modify physiology and development at the molecular level to ensure maximal fitness. Central in the signaling network is the SnRK1 kinases (homologous to AMPK and SNF1 in mammals and yeast respectively). These kinases are vital to the energy balance of the organism and regulate primary metabolism by controlling transcription factors, which control the expression of genes encoding key enzymes. SnRK1 signaling and reprogrammed metabolism have turned out to be crucial for establishments of tolerance and sustained growth during stress.This proposal suggests a multilevel approach to signaling in which all levels of the signal transduction pathway are addressed. The proposal is truly interdisciplinary and a wide range of methodology will be deployed ranging from classical physiology to state-of-the-art mass spectrometry based protein and metabolite profiling, massive sequencing of immuno-precipitated chromatin and whole genome expression profiling. This will be further supported by bioinformatic approaches, phylogenetical as well as network based. The aim is to understand the mechanisms regulating energy balance in plants and their impact on plant performance under stress. Improved stress tolerance of plants is of strategic importance in a world with rising population and changing climate. This strategic importance as well as future recruitment possibilities motivates the high involvement of industrial partners in the proposed activities.The proposed training activities will coach future top-performers for professional career in the biotech industry as well as in the academia. The training program includes network-wide workshops (methodology, industry relevant skills and more) as well as structured local training in the host instit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Integrated analysis of expression and chromosomal organisation of genes localised on human chromosome 1q21: implications for human disease and cancer'.

assistant: **Innovation**

Chromosome 1, which is the largest human chromosome and harbours about 8% of the entire human genomic information, reveals in region lq21 a most remarkable clustering of genes that fulfil important functions in development and differentiation. Among twenty-five individual genes identified and physically mapped so far, fifteen encode structural proteins that are indispensable for terminal differentiation of the human epidermis and ten are genes for S100A small calcium binding proteins involved in signal transduction and cell cycle progression. Co-localisation of genes coding for calcium binding proteins with genes expressed late during epidermal differentiation is particularly intriguing since calcium levels tightly control the differentiation of epithelial cells and the expression of genes encoding epidermal structural proteins. Moreover, S100 proteins have been found to be differentially regulated in human cancer cells and region lq21 is often rearranged in human tumours. In addition, amplification of region lq21-q22 has recently been identified in human sarcomas. Since the groups joining for this proposal have previously been engaged in the identification and/or mapping of these important clustered genes, it appears appropriate to concentrate European resources for a combined, multidisciplinary effort aiming at a comprehensive characterisation of all known and novel genes residing in region lq21 and their tissue-, developmental-, and differentiation specific regulation. Likewise, the potential role of these genesin genetic disorders of keratinisation that obliterate the physical and chemical resistance of human epidermis will be analyzed as will be the effects of their disproportionate representation and abnormal regulation in tumorigenesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'MeAsuRements by LasEr techNiquEs' (MARLENE), addressing dissemination and exploitation.

assistant: **Impact**

There are two main areas in which laser - based measurements techniques have proved to be extremely effective and have therefore found wide application: vibration measurements and flow velocity measurements. Laser- based measurement techniques for the eval uation and analysis of vibrations (Laser vibrometry, ESPI, Holographic interferometry, etc.) and Laser- based flow velocity measurement techniques (FIV, LDV, etc.) are highly employed in a variety of industrial fields (aerodynamics, car industry, turbomach inery, combustion) and in other areas such as biomedicine, artworks etc. The MeAsuRements by LasEr techNiquEs (MARLENE) proposal, is a project which arms at: ? disseminating knowledge in laser technology stored up by universities, research institutes and e nterprises; ? promoting formation and training of researchers and engineers in the laser measurements field; ? creating and stimulating an active forum where researchers, manufacturers and experts in the field of optical and non invasive instrumentation, a nd industrial users can share current research results, expertise and technical advances; ? enhancing gateway activity to promote future co-operations and projects; ? establishing and cultivating active and fruitful relations among researchers and engineer s from universities, research centres and enterprises in order to favour the continuous dissemination and exchange of knowledge and discoveries; ? favouring interactions between the academic field and enterprises; ? presenting needs and problems which can be solved with the use of laser systems; ? promoting the development of new systems for laboratory use, field testing and industrial applications and supporting new applications. In order to reach the aims Usted above, the following series of events will b e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Scalable Computer Architecture' under Sixth Framework.

assistant: **Concept**

SCALA is an integrated project concerned with long-term research in advanced computer architecture. It focuses on a systematic scalable approach to systems design ranging from small energy critical embedded systems right up to large-scale networked data servers. As current methods of designing computer systems will no longer be feasible in 10 -15 years time, what is needed is new innovative approach to architecture design that scales both with advances in underlying technology and with future application domains.This is achieved by fundamental and integrated research in scalable architecture, scalable systems software, interconnection networks and programming models each of which is necessary component in architectures 10+ years from now. If successful, this will allow Europe to capitalise on its dominance in embedded systems and interconnection networks and gain market share as consumer electronics and general purpose computing continue to converge.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Photoactive Metal-Organic Framework for Solar-Driven Atmospheric Water Harvesting in Arid Climates' in the context of a Horizon Europe call.

assistant: **Objectives**

Atmospheric water harvesting (AWH) using solar energy has gained significant attention; however, its application in arid climates poses challenges due to low relative humidity (RH) and reduced efficiency of conventional sorbents. metal-organic frameworks (MOFs) are a class of porous materials with an engineerable structure that have the ability to capture water even at very low RH. Usually, the combination of photothermal materials with MOFs is used to desorb water sorbed by MOFs. One of the challenges of this method is the reduction of MOF sorption capacity, which is very unfavorable, especially in arid climates. Reducing the performance of sorbents in arid climates due to the blocking of sorption sites by dust is another challenge that has received little attention so far. To address these challenges, this study evaluates the synthesis of a unique water-stable MOF with photothermal and photocatalytic (photoactive) properties (PAMOF), in addition to high water affinity. Phthalocyanine and porphyrin ligands decorated with Ti and Cu ions, along with Yttrium (Y) and Erbium (Er) clusters, are considered as promising candidates. Molecular modeling using density functional theory (DFT) will be conducted to guide the synthesis process, followed by experimental synthesis and characterization. Subsequently, the samples will be evaluated in an AWH device to assess short-term efficiency and long-term maintenance in real conditions. In addition to harnessing natural solar energy, the AWH experiments will involve the utilization of a custom-made solar simulator. The SAWH device will be evaluated across a range of RHs, spanning from 10% to 90%, while considering the presence of artificial dust. Through comparative analysis of existing research and with the aim of enhancing previousl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'To host an Innovation Relay Centre covering the South West region of England'.

assistant: **Objectives**

This proposal is being submitted by the South West of England Regional Development Agency (SWRDA). For the past 2 years, SWRDA has hosted the South West of England Innovation Relay Centre (SWIRC). As the sole contractor for this project, SWRDA will seek to improve the overall innovation and technology exploitation performance of the South West of England by ensuring that SWIRC continues to work in concert with other regional business support agencies in order to provide high quality Transnational Technology Transfer (TTT) services to its clients. The proposal indicates how the project's objectives contribute to the scientific, technical, wider societal and policy objectives of the Research and Innovation activity area. It demonstrates that, by working closely with a range of other initiatives across the region, the project will have a substantial impact on SWRDA's ability to deliver key aspects of its Corporate Plan. The proposal establishes that, given its experience of managing SWIRC since April 2000, SWRDA is a suitable and committed host organisation which will ensure that the project is managed and delivered successfully. From a methodological perspective, the proposal shows how SWIRC will provide the best possible innovation and TTT support to SMEs in the South West of England by tailoring its services to suit the innovation needs of client firms. At a regional level, the proposal highlights the fact that SWIRC will be a major source of expertise in the exploitation of intellectual property and in transnational technology transfer for the South West of England during 2004 - 2008 and beyond. At a European level, the proposal indicates how SWIRC will help to strengthen and develop the IRC network by playing an active role as a network member. Finally, by demonstrati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Microfluidic chambers for establishing physiological and pathological human iPSC-derived neuronal circuits'.

assistant: **Concept**

In vitro cultures of brain cells generate an ease and accessible ensemble of neurons In vitro cultures of brain cells generate an ease and accessible ensemble of neurons which has been invaluable for innumerable cellular and molecular studies. However, brain tissue dissociation and neuronal plating in vitro causes a complete loss of the original connections present into the brain tissue. Therefore, in vitro neuronal cultures do not allow to model specific neuronal circuits and study their specific properties. The same limitation is valid for human stem cell-derived neuronal cell cultures. In fact, several neuronal cell types can be differentiated from human iPS cells (iPSCs), but without any organization in terms of connectivity or synaptic specificity. We have established a microfluidic platform, named BrainCircuit-on-chip, which allows to growth human iPSC-derived neurons with a stereotyped organization and to establish patterned connections between different neuronal cell types. These microchips contain a central chamber where synapses between the two neuronal cell types are generated establishing the correct functional integration between the two neuronal populations. PDMS-microfluidic chambers are transparent and enables high-power and time-lapse imaging in the different neuronal compartments for sub-cellular and molecular studies. Moreover, the design of the central chamber enables to expose the synapses to chemicals or other cells types like astrocytes or microglia to study their effects on a specific class of synapses. We will produce a convenient kit with the frozen human neurons, the microfluidic chamber and a detailed protocol for generating the patterned neuronal circuits for research studies, compound testing and toxicology research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular mechanisms controlling X chromosome inactivation' (2007-2013) under Seventh Framework.

assistant: **Objectives**

In mammals, gene dosage of X-chromosomal genes is equalized between sexes by random inactivation of either one of the two X chromosomes in female cells. In the initial phase of X chromosome inactivation (XCI), a counting and initiation process determines the number of X chromosomes per nucleus, and elects the future inactive X chromosome (Xi). Xist is an X-encoded gene that plays a crucial role in the XCI process. At the start of XCI Xist expression is up-regulated and Xist RNA accumulates on the future Xi thereby initiating silencing in cis. Recent work performed in my laboratory indicates that the counting and initiation process is directed by a stochastic mechanism, in which each X chromosome has an independent probability to be inactivated. We also found that this probability is determined by the X:ploïdy ratio. These results indicated the presence of at least one X-linked activator of XCI. With a BAC screen we recently identified X-encoded RNF12 to be a dose-dependent activator of XCI. Expression of RNF12 correlates with Xist expression, and a heterozygous deletion of Rnf12 results in a marked loss of XCI in female cells. The presence of a small proportion of cells that still initiate XCI, in Rnf12+/- cells, also indicated that more XCI-activators are involved in XCI. Here, we propose to investigate the molecular mechanism by which RNF12 activates XCI in mouse and human, and to search for additional XCI-activators. We will also attempt to establish the role of different inhibitors of XCI, including CTCF and the pluripotency factors OCT4, SOX2 and NANOG. We anticipate that these studies will significantly advance our understanding of XCI mechanisms, which is highly relevant for a better insight in the manifestation of X-linked diseases that are affected by XCI.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Genomic sequence variants that correlate with gene expression and different epigenetic patterns modify risk for mTLE+HS' (MTLE-HS) targeting Seventh Framework.

assistant: **Abstract**

Epilepsy is the second most common neurological disorder after stroke and mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE+HS) represents the most common epilepsy syndrome in adult patient with medically intractable partial epilepsy. Studies of genome-wide association (GWA) with epilepsy are critical to provide an unbiased assessment of genes contributing to disease risk and/or response to treatment. However the results of GWA studies give little information about the underlying disease mechanisms. The proposed research project will try to identify those genomic sequence variants that correlate with gene expression and different epigenetic patterns that could modify risk for mTLE+HS. Starting with an already established epilepsy GWA study, we propose to obtain gene expression and methylation data from 100 biopsy specimens obtained from well-characterized chronic pharmacoresistant mTLE+HS patients, who underwent resection of the temporal lobe at the National Hospital for Neurology and Neurosurgery (NHNN) and for whom we already have whole-genotyping data. Individuals will be matched for age, gender and ethnic background with healthy controls from two ongoing whole genome expression and methylation studies at UCL. The integration of gene expression with genetic variability will provide insights into the causal variants and how this may lead to mTLE+HS. In addition, we will investigate an additional biological mechanism, methylation that could alter an individual's susceptibility to mTLE+HS risk. Our interdisciplinary approach will contribute to the understanding of the molecular mechanisms underlying mTLE+HS pathology. In the long term, this understanding will lead to the preventative identification of high-risk patients and the development of novel therapie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Risk Analysis, Ruin and  Extremes""' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This project, named Risk Analysis, Ruin and  Extremes (RARE), aims at developing the theoretical side of the analysis of ruin probabilities in case of disasters or extreme shocks for insurance-like risk pools, by the introduction and analysis of new risk measures, and by (asymptotic)quantification of aggregated risk, central topics of interest for the prediction of financial disasters and more generally for risk management.Since specialists working on the areas of extremes and rare events are scarce and sparse, such an exchange program helps creating a needed network of knowledge, ideas and experience. We propose 12 international leading research centers from European, emergent and developed countries, to establish an initial network basis of 20 experienced researchers and 20 early stage researchers.""