RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Set to change: early life factors restricting and promoting neurocognitive plasticity through life' (Set-to-change), addressing dissemination and exploitation.

assistant: **Impact**

Cognitive function in old age can be predicted from how you functioned when you were young. This is remarkable, as there are substantial cognitive age changes. Are we neurodevelopmentally set to change through life in certain ways? The objective of Set-to-change is to test whether and how early life environmental factors and genetic makeup interact to regulate neurocognitive plasticity through the lifespan. Neurocognitive plasticity; i.e. changes in brain and cognition in response to environmental demands over time, shows huge individual variability, for unknown reasons. Neurodevelopmental origins of functional variation through the lifespan are acknowledged, but the pathways need to be identified. As individual constitution and environment are intrinsically correlated, to make progress beyond state of the art, this can only be tested in an experimental setting.The novelty and ground-breaking nature of the project lies in the synthesis of a targeted experimental approach testing differences in neurocognitive plasticity by training of younger and older adult mono- (MZ) and dizygotic twins (total n = 400 individuals), with varying degrees of prenatal environmental variance, as indexed by their extent of discordance in birth weight (BW). BW discordance in MZ twins enables me to disentangle early environmental and genetic influences on neurocognitive plasticity. I will employ a novel ecologically valid memory intervention utilizing navigation with true locomotion and prospective memory in virtual reality. Twins will be assessed with brain MRI, cognitive, health and epigenetic measures at multiple time points spread across 2.5 years pre- and post- 3 months intervention in a AB/BA crossover design, to investigate neurocognitive plasticity and age change longitudinally, as wel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel Materials Based on Alkali Chromites and Manganites  for the Generation of Magnetic Skyrmions' (ACHROMAS).

assistant: **Innovation**

The planned project explores a new class of frustrated magnets with the potential to host magnetic skyrmions. Skyrmions are nanoscale magnetic states and can be characterized as topologically protected spin vortices. They can be manipulated using low electric currents, thus can act as information bits in a new generation of energy efficient, ultradense memory and logic devices. Until now skyrmions have mainly been found in chiral magnets and at the surfaces of certain materials, but are often limited to a tiny pocket of the applied magnetic field versus temperature phase diagram. Furthermore, the skyrmions themselves in these systems are often of tens of nanometers or more in size, thus too large to be useful as information bits. Recent theoretical works have predicted that much more compact skyrmions might be found in frustrated magnets, and guidelines have been established to identify the most desirable structure features for hosting skyrmions. One group of materials that meet the structural criteria are the alkali chromites and manganites ABO2 (A = Na, K, Rb, Cs; B = Cr, Mn) and their derivatives, which are the focus of the proposed research. A comprehensive physicochemical investigation of the ABO2 family will be carried out, using cutting-edge methods of syntheses and modern analysis techniques for the determination of structure and composition. An investigation of their bulk magnetization and transport properties, combined with a study of their magnetic structures using Lorenz microscopy, neutron and resonant X-ray scattering, will enable magnetic phase diagrams to be mapped out and skyrmion phases to be identified and characterized. This interdisciplinary project involves close relationships between multiple related fields of science, such as solid state and magn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Applications of nanobiotechnologies to yeast: optimization of bioprocesses for products of industrial, medical and agricultural importance.', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The goal of this project is to develop Nan biotechnologies in order to exploit information obtained from global gene expression studies. The programme wills the built on the use of reliable, cheap and re-usable micro/macro arrays for high throughput, low-costs screenings. Their technological development will enable to restore the competitive position of European industry. S. Cerevisiae, the only eucalypti for which the complete genome sequence is available and the functions of the genes are being rapidly elucidated will be used to characterize in details regulatory networks on a genome-wide scale. Drawing the integrated genetic and metabolic map of this simple eucalypti will allow biotechnologicalimprovments of many bioprocesses, access to key target genes homology to human genes involved in diseases and systematic screening of new drugs and fungicides.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Chaotic dynamics of multi - dimensional hamiltonian systems and applications to partial differential equations of physical significance' under Fourth Framework.

assistant: **Concept**

Research objectives and content The main purpose of this project is to investigate analytically and numerically the chaotic properties of multi-dimensional dynamical systems. In particular, we will study near-integrable discretizations of certain partial differential equations (pdes) of physical significance like the Nonlinear Schrodinger equation describing pulse transmission in optical fibers and the sine-Gordon equation monitoring the flux of supercontacting current in Josephson junctions. Besides the relevance of our study to the continuum limit of the corresponding pdes, we will also analyze our systems as multi-degree-of-freedom Hamiltonian lattice models. Thus we expect to obtain results concerning the existence and stability of localized oscillatory excitations called breathers, as well as investigate energy transport between interacting breathers. Our basic analytical tools will be the application of invariant manifold theory, Mel'nikov analysis and 'horseshoe' dynamics to establish the occurrence of homoclinic chaos. We also intend to apply various other methods, like the implicit function theorem in the so-called anti-continuum limit which have recently proved very useful in the investigation of such breather solutions. Guided by our analytical results we also plan to carry out extensive numerical computations to study the stability of our localized oscillatory states and global behavior of these systems for very long times. Training content (objective, benefit and expected impact) My stay at Cambridge is expected to be of great benefit as it well enable me to work with outstanding researchers in the field of Hamiltonian Dynamics. Furthermore, my background in higher-dimensional Mel'nikov analysis, invariant manifold theory and pdes should be beneficial for t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Postdoctoral Program in Integrative Kidney Physiology and Pathophysiology'.

assistant: **Concept**

Chronic Kidney Disease (CKD): the silent epidemic. CKD is a progressive condition due to irreversible kidney damage and loss of function. Recent data show that 10% of the European population has some degree of CKD, sometimes progressing to dialysis or transplantation. The CKD prevalence is rising because it is linked to other modern epidemics such as obesity, hypertension or diabetes. Worldwide more than 50 million people are affected, leading to costs of more than 6% of health care budgets. Unfortunately in most cases people are unaware of the fact that they have CKD. In a recent meeting at the European Parliament, the European Kidney Health Alliance called for European health policies to support early identification and treatment of CKD. Efforts should be pulled together at European level by putting the prevention of CKD high on the agenda, through exchange of best practices between Member States and improvement of existing technologies for early CKD detection. Integrative Kidney Physiology and Pathophysiology – a Swiss Postdoctoral program. The main reason for the devastating consequences of impaired renal function is the central role of the kidneys in body homeostasis. In this regard our network of nephrologists and renal physiologists builds on a longstanding and strong tradition of kidney research in Switzerland. We propose to gather leading specialists in experimental and clinical nephrology to set up a new Postdoctoral program at Swiss Universities for European fellows, in order to strengthen integrative thinking and awareness for kidney-centered homeostatic systems. Our program will provide Europe with a new generation of kidney researchers and considerably improve the research quality of the ERA. Postdoctoral fellows will be trained in communication and manage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Green and robust approaches towards dual-purpose dendritic adhesives: Novel minimally invasive methodologies for bone fracture fixation applications' (DendroBAP).

assistant: **Innovation**

A vast number of human bone fractures rely on screw-fixated metal implants.  While being effective, their rigid design, combined with open surgical conditions and general anesthesiology, make them poor candidates for thin or fragile bones, such as those that might be found in the elderly population.  The proposal is intended to identify a minimally invasive surgical concept, based on novel bone adhesives (glues) for treatment of complicated bone fractures, under local anesthesia. This will be accomplished by developing a library comprised of a dendritic scaffold, a cross-linker and a fibre component.  Upon mixing, the dendritic component is programmed to efficiently adhere to wet bone surfaces and on-demand react with the cross-linker to form a bone adhesive patch (BAP).  The fibre component is embedded to produce BAPs covering a range of load bearing properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'New system for recovery of valuable metals from exhausted xatalyst'.

assistant: **Concept**

All industrial processes Inevitably lead to the creation of sub-products which, unless another use of fund for them, are regarded as waste. They are a source of land, water and air pollution. Often, products regarded as waste contain precious materials because they are rate or difficult to extract. This is why now increasingly attempts are made to minimise the amount of waste, to recycle or re-use sub-products as secondary raw materials. The aim of the present research project is to study processes, systems and technologies capable of recovering precious metals from spent catalysts. Catalysts in fact contain metals with a high economic value (such as Molybdenum and Vanadium, as well as others) which, if recovered, could allow rational re-utilisation of the raw materials in full compliance with the approach encouraged by the European Community. The process idea The central idea is to recover the metals present in spent catalysts using a chemical process which consists in: 0 a first phase where the catalyst is dissolved to obtain a solution containing the metals in liquid state; 0 a second phase where the metals react in order to obtain a precipitate in salt form Obviously the process is already at the level of laboratory tests and additional, substantial research activity is needed to create a pilot system that exploits the process in order to recover Vanadium and Molybdenum from all spent catalysts containing them. It is also important to discover methods of recovering the metals present in the catalysts most frequently used in industry throughout Europe. More specifically, it is necessary to: test the possibility of recovering other metals from catalysts, quantify the costs and economic benefits of industrialising the process; in particular, we need to find out in what
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Live attenuated replication-defective influenza vaccine' (FLUVACC) under Sixth Framework.

assistant: **Objectives**

We propose to develop an intranasal vaccine against pandemic influenza, based on reverse genetics. This technology will permit to rapidly generate replication-defective strains from new emerging influenza viruses that are safe and effective. We will generate reassortant vaccine viruses containing the surface glycoproteins from emerging wild-type influenza strains and the internal proteins of a master strain lacking the NS1 gene. The efficacy and safety of the resulting vaccine strains will be evaluated in chickens and ferrets. In addition we will scale up our production technology based on Vero cells. To establishing a fast and efficient downstream process we will further develop and scale up our purification method on monolithic columns. Subsequently, after toxicological evaluation of the cGMP produced candidate vaccines, clinical studies will be performed in healthy volunteers.The complementary constellation, the quality of the partners, efficient project management and availability of the combined resources will enable to successfully reach the goals of this project. It will allow the SMEs to significantly shorten the time necessary for the preclinical development phase and will bring the proposed chimeric vaccine viruses a major step closer to a marketable stage. Therefore, the project will contribute to the integration of partners in European research networks and, by its highly innovative features strengthen the European research. Through the involvement of partners from the Czech republic and from Slovenia this project contributes to the integration of new member states. Due to the enormous market potential, significant earnings can be expected. The patents, virus strains and technologies generated through these project will allow the SMEs to negotiate significan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Plasma membrane to nucleus trafficking of the transcriptional co-activator BRX - characterization of a novel hormone signaling pathway in plants' to be submitted under Seventh Framework.

assistant: **Abstract**

A major question in biology is how external and internal cues are perceived by the organism and translated into an adequate response at the cellular level. For instance, organ growth in plants involves a phase of cell expansion, which requires extensive rearrangement of cell wall structure and is triggered by systemic cues, such as phytohormones. The complex topic how such cues are interpreted is of major interest in the field of cell biology, which has succeeded in deciphering various intra-cellular signaling pathways. Nevertheless, additional, conceptually different pathways very likely remain to be discovered. A recent example for a conceptually novel pathway is the perception of the phytohormone auxin in the nucleus by direct binding to and regulation of a certain class of E3 ubiquitin ligases, the auxin receptors . Auxin is of pivotal importance in various processes of plant development throughout the life cycle, mainly through its dose-dependent influence on cell proliferation and elongation. In this proposal, we aim to investigate a novel, parallel auxin signaling pathway involving the plant-specific BRX protein that has been recently discovered in the host lab. Unlike the nuclear auxin receptor pathway, this pathway involves plasma membrane to nucleus signaling and responds to alterations in trans-cellular auxin transport, a key phenomenon in plant organogenesis. The aim of this proposal is to solidify the evidence for this pathway and characterize it in more detail to answer two key questions: i) how is BRX, a transcriptional co-activator, targeted to the plasma membrane in a polar fashion? and ii) what is the mechanistic basis for endocytosis-rate and hormone-triggered nuclear import of BRX? We expect that the anticipated results will not only shed light on a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'LARGE-SCALE LOW-TEMPERATURE ELECTROCHEMICAL CO2 CONVERSION TO SUSTAINABLE  LIQUID FUELS'.

assistant: **Innovation**

ECO2Fuel aims to design, manufacture, operate, and validate the worldwide first low-temperature 1MW direct, electrochemical CO2 conversion system to produce economic and sustainable liquid e-fuels (C1-C4 alcohols) under industrially relevant conditions (TRL7). This will be achieved by the direct electrocatalytic reduction of CO2 using water and renewable electricity without hydrogen at temperatures and pressures below 80?C and 15 bar, respectively. Due to its compatibility to dynamic loads, the ECO2Fuel system allows the efficient and direct coupling to renewable energy sources (RES) or facilitating grid-balancing service. The ECO2Fuel system is based on a genuinely unique CO2 co-electrolysis technology developed under the Horizon 2020 project LOTER.CO2M. This system will be optimized to produce efficiently and selectively C1-C4 alcohols and upscaled from 5kW with an unpretentious approach to a size of 1MW within the ECO2Fuel project. The produced e-fuels will be evaluated as green alternative feedstock in two of Europe?s CO2 emission heavy sectors, transport and energy.


**Keywords:** Power2X, GHG reduction, low-temperature CO2 electrolysis, LOTER.CO2M, e-fuels
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'X-Europe' to be submitted under Horizon 2020.

assistant: **Abstract**

The X-Europe Consortium brings together leading training, acceleration, events, and media companies from across Europe. Together we will link the developing regions of the Baltics and the Visegrad region to the wider European ecosystem, rebalancing the flow of socio-economic capital. Through the delivery of training, matchmaking & promotional services X-Europe will support 150 deeptech startups and help them to internationalise, grow across borders, and into developing frontiers.The consortium has been selected carefully to ensure that each aim can be well attained. We have chosen a leading international training organisation (Growth Tribe), a strong ecosystem builder working to connect the Visegrad region through acceleration & connecting activtities (Design Terminal). Two companies (TNW & F6S) have large databases of startups, investors and job/talent communities. Finally, 2 leading international event orgnaisations in TNW and Techchill have been selected to boost the program exposure and put ecosystem connecting activities central to the programme.The programme will last 26 months and create positive feedback loops to ensure sustainable and mutually supportive impact on developing ecosystems and their deeptech beneficieries. After the completion of the project we expect higher levels of investment and partnership in developing regions and greater awareness of the opportunities and innovations available within the Visegrad and Baltic regions.X-Europe will be an iconic and flagship programme creating high levels of exposure, engagement and be a leading example on how to connect ecosystems and distribute opportunties and growth across the European Union.


**Keywords:** Matchmaking, Ecosystem Building, Events, Training, Service Provision, Deeptech