RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The missing link: inhibitory interneurons as the core of anxiety and depression comorbidity' (ZoomINs).

assistant: **Innovation**

Rates of depression and anxiety are constantly surging, resulting in a growing global mental health crisis. These two disorders have a remarkably high prevalence of comorbidity, with anxiety generally preceding depression. However, the biological basis of these disorders and their comorbidity is poorly understood, leaving millions of patients with inadequate treatments and thus an urgent need for improved medications. Accumulating evidence suggests that both disorders involve GABAergic deficits, but the nature of these deficits is undefined and may be the holy grail for cracking the mysteries of depression and anxiety comorbidity. Here, I will apply cutting-edge technologies to focus on hippocampal GABAergic interneurons (INs) and propose a data-driven hypothesis for the cellular and molecular basis of anxiety and depression comorbidity. I suggest that INs selectively recruit microglia to reshape inhibition in the depressed brain. This hypothesis may provide the missing link between major hallmarks of depression: GABAergic deficits, synaptic loss, and neuroinflammation. I seek to unravel the molecular adaptations of INs to stress that lead to microglia recruitment and connect them with anxiety preceding depression. Finally, I will elucidate a novel model for innate anxiolysis mediated by local dendritic translation in INs. I will combine, for the first time, the robustness of two analytical methods: translating ribosome sequencing and spatial transcriptomics to identify the involved genes, the INs subtypes expressing them, and their hippocampal location. These data will be complemented by calcium imaging, behavioral tests, imaging, connectomics, and electrophysiology. ZoomINs targets an urgent public health concern by providing a novel hypothesis for a long-standing que
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Reduction of volatile organic compound residues in emulsion polymer processes'.

assistant: **Innovation**

Determination of the key parameters implied in reduction of volatile organic compound residues in emulsion polymer processes. Theses key parameters may be based on the emulsion polymerization technologies or on the chemistries used during the process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Aerodynamic and acouStic for high-by-Pass ratIo tuRbofan intEgration' in the context of a Horizon 2020 call.

assistant: **Objectives**

The ASPIRE proposal, gathering DLR, NLR, ONERA and TsAGI, responds to the topic JTI-CS2-2014-CFP01-AIR-01-01 “Aerodynamic and acoustic capabilities developments for close coupling, high by-pass ration turbofan Aircraft integration”. The comprehensive experience of the partners working on innovative engine aircraft integration concepts both individually and in previous collaborative efforts motivated their common application. The high level objectives of the ASPIRE proposal lead to improve and validate numerical and experimental capabilities to assess the aerodynamic and acoustic performance of innovative aircraft configurations equipped with ultra-high by-pass ratio turbofan (UHBR). For that purpose, the numerical activities will be performed on a reference configuration partially designed by the consortium (generic fan/OGV combination) and by the lead industrial partner (nacelle, pylon, wing). Cross-comparison of codes are foreseen in specific tasks to improve the reliability of tools and better understand the tremendous interactions between airframe and UHBR engines. The experimental activities aim at improving the efficiency of acoustic means during wind-tunnel and flight tests.  The ASPIRE total grant request to EC is 2 908 235 € for DLR, NLR and ONERA, the activities conducted by TsAGI being funded outside (national grant). The project will be conducted over 33 months in close alignment with the overall LPA-IADP and AIRFRAME-ITD needs and in agreement with the concerned IADP & ITD industrial coordinators and further selected and involved core partners and/or partners. The ASPIRE proposal will also be conducted in manner consistent with the other research activities performed in the AIRFRAME-ITD and the LPA-IADP. The integration of experimental and numerical capabil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Maritime industries virtual enterprise linkage' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

To assure best exploitation of IT developments for the benefit of the industry and the environment it is imperative to identify and harmonise basic requirements of wide user groups. The co-ordination and harmonisation of user requirements finds an easy test-bed in maritime industries, as they have natural experience in horizontal and cross-sectoral approaches. MARVEL OUS's objective is to identify and harmonise generic requirements for use of advanced IT in manufacturing and engineering across the maritime industry building up links with other sectors for mutual benefit. The project will guarantee consensus on requirements across the whole range of maritime users and work closely with the technology providers. It will also ensure that the end-user requirements are feasible and can be translated into product development.This project will develop detailed specifications of IT user requirements and will start the prototyping effort that will ultimately test and demonstrate the concepts. The effort will be continued in separate projects, co-ordinated by MARVEL OUS.MARVEL OUS is an end-user driven project. The impetus behind the development comes from the end-users of the system: Euroyards a consortium of five major European Shipyards (Astilleros Españoles, Vulkan Schiffbau-Verbund GmbH, Chantiers de l'Atlantique, FINCANTIERI, Howaldtswerke - Deutsche Werft AG) and Odense Steel Shipyard Ltd. are representing the European Marine Industry. MARVEL OUS will be strengthened by the participation of the classification societies Lloyd's Register of Shipping, Det Norske Veritas, Germanischer Lloyd and Research Institutes such as, BMT and BIBA. MARVEL OUS will install open IT and Vendor Groups to guarantee the transition of the user requirements to the IT products and further User Gro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular understanding of metabolic complexes: Towards engineering the next generation of synthetic biosystems' (METABOLON).

assistant: **Concept**

Why most plant natural products escape industrial production? So far, synthesis of many of these high-value compounds in microbes is simply based on putting together all the players in a pathway. Nevertheless, to produce its stunning chemical diversity, nature uses much more elaborate biosynthetic networks, frequently involving the formation of macromolecular assemblies termed metabolons. These complexes utilize dynamic interactions and partner exchange to produce the desired compounds in a coordinated fashion. To take my biotechnological expertise one step further, I will study the dynamic mechanisms that rule the assembly and regulation of metabolons and use this knowledge to reshape the way microbial production platforms are engineered.METABOLON clearly introduces a new level of analysis and intervention into metabolic engineering, by examining the efficiency of complex formation and the fine molecular details that could affect enzyme performance. In addition, it develops tools and methods to obtain a molecular understanding of the role of the host membranes in heterologous enzyme function. Importantly, it introduces the concept of altering the host environment to mimic that of the native pathway host, and suggests approaches to achieve this in the case of the ER membrane. With a pressing need to move towards a bio-based society (H2020 priorities), METABOLON will set the blueprint for the rational engineering of the many complexes that create a plethora of bioactive compounds, natural aromas, flavours and colours. METABOLON will help me immensely to develop a unique skill-set that brings together my previous expertise in metabolic engineering with newly acquired knowledge in enzymology, single-molecule microscopy and biophysics. This will enable me to develop an inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A novel method for pigment production from seafood industry waste' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The main objective of this project is to develop a sustainable adsorption method for isolation and production of natural pigments of high commercial value. The basic innovative feature of the method is the application of solid waste from fisheries as a natural adsorbent of pigments. The principal product target is a natural pigment, astaxanthin, extracted from seafood industry wastes of crustaceans. There are commercial interests in astaxanthin production for feed formulations and as nutraceutical, as prices and market value are high and growing. Astaxanthin in commercial use is produced synthetically. Consumers are increasingly interested in natural feed and food additives, but the commercial availability of natural astaxanthin is limited. The benefits of this innovation are both economical and ecological:1. Production of natural pigments.2. Better use of waste from crustacean industry.3. Purification of wastewater from crustaceans industry.4. Value-added product from
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Zebrafish avatar as a real-time in vivo platform for personalized cancer therapeutics' in the context of a Horizon 2020 call.

assistant: **Objectives**

The Zebrafish Lab is a biotechnological company leader in the development and commercialization of novel, tailor-made solutions based on in vivo zebrafish assays. Thanks to the extensive knowledge acquired by the R&D projects performed in the field by our team for many years and a close collaboration with Hospitals and Cancer Research Institutions, we have identified a remarkable opportunity in MY FISH CURE project that will mean a 5-year after tax-R.O.I of 490% according to our estimations. The ultimate goal of the project presented as MY FISH CURE is to complete the clinical studies required to bring to the healthcare market a novel real time in vivo platform for personalized cancer treatment based on the use of zebrafish “avatars” as personalized, living test tubes. Cancer is a leading cause of morbidity and mortality with approx. 35 million people affected by this disease and more than 7 million deaths per year. A major difficulty found in effective cancer treatment is the complexity of the biological mechanism underlying cancer onset and disease progression. As such, different people respond differently to the same therapy. Personalized cancer therapy can provide a solution to these challenges in cancer treatment. In MY FISH CURE project we seek overcoming the mayor barriers currently preventing the use of zebrafish avatars as in vivo models for patient-directed interventions, so for their use in a clinical context instead of a research or drug development context. Thanks to MY FISH CURE project, we will become the first company in the world offering zebrafish avatar models for personalized cancer care.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Monitoring forest degradation using terrestrial lidar and satellite images', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Natural resource managers, policy makers and researchers demand knowledge of deforestation and forest degradation over increasingly large spatial and temporal extents for addressing many pressing issues such as climate change mitigation and adaptation, carbon dynamics, biodiversity, and food security. The scientific community is witnessing a significant increase in the availability of different global satellite derived biophysical data sets (e.g. biomass and surface photosynthesis). However, the use of such data is not supported by accurate in-situ biophysical measurements (e.g. canopy structure) for the monitoring of forest and land dynamics. Consequently, there is an urgent need for methods to measure in-situ canopy structure accurately and better integrate with improved and innovative remote sensing approaches.Major advancements in laser technology and earth observation are offering a revolution in information. An innovative science program is required to fully realise the benefits of these discrete technological advancements. This proposal addresses this need by solving three core challenges. Firstly, methods are developed to retrieve forest canopy structure attributes and biomass using a novel type of ground-based upward-looking laser scanner.  Secondly, a physical modelling approach is used which provides a more rigorous framework than prior methods, which largely used regression relationships, to study relationship between the retrieved canopy attributes and satellite data. Finally, these accurate satellite-derived biophysical data sets enable assessment deforestation and forest degradation. However, existing methods to detect changes in satellite data are not able account for seasonal climatic variations. A new approach is therefore proposed to account for seaso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Software architectures for ship product data integration and exchange' (SEASPRITE).

assistant: **Innovation**

In order for the European marine industry to retain and increase its market share, it must take advantage of the possibilities afforded for information handling technologies and methods, which are becoming available.  In order to facilitate this, the objective of SEASPRITE will be to create, implement, test and evaluate an architecture to enable the management, monitoring and transfer of ship hull data throughout the ship lifecycle; from tendering, initial conceptual design through model basin tests, plan appraisal, stability and loading analysis, detailed design, production, operation and repair. The data to be managed will include the hull definition, steel structure, internal arrangements and compartmentalisation, space usage, loading, and hull structural survey results. This product data will be supported by data representing work flow, quality and project information. SEASPRITE will demonstrate its application in a number of business scenarios.The architecture supporting the integrated engineering management systems will ensure that not only is data exchanged, but that there is real management of the data in the context of business usage. The data will be encapsulated at the highest level, whether this be as a ship or project, having the effect that the lifecycle management will require the roll-on of a single high level entity rather than a collection of disparate data items.In order to provide an efficient implementation the underlying requirement is the development of a complete ship product model to act as the basis for a Data Exchange and Management (DEM) architecture. SEASPRITE is an end-user project, driven by the need for the European maritime industry to make maximum utilisation of the information handling capabilities of Information Technology and communi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Biogeochemistry of an acidic and metal-rich river-estuary system, consequences for atlantic shelf waters' (TOROS) targeting Fourth Framework.

assistant: **Abstract**

Its objectives are: 1) To quantify fluxes of traces metals discharged by the Rio Tinto and Odiel to the Gulf of Cadiz and assess how this is modified by estuarine processes during the extreme pH (2-8) changes encountered in this system. 2) To determine the fate and fluxes of metals in the Gulf of Cadiz and their relation to hydrodynamics and biological activity. 3) To record effects of human activities through historical times, from ancient mining (Phoenician, Roman) to the next closure of the present mine.TOROS is a mulstidisciplinary approach which intends to study the inputs of two acidic (pH 2) and metal-rich  rivers (Tinto and Odiel rivers) draining one of the most important sulfide mineralised in the world and  discharging in the Gulf of Cadiz which provides up to 20% of the Mediterranean inflow waters.  Dissolved trace metal (Cd, Cu, Ni, Co, Pb, Zn, As, Fe, Mn) concentrations and speciation will be determined  in the Tinto and Odiel rivers, estuary and in the Gulf of Cadiz. The mobilisation of trace metals from the  sediment to the overlying waters will also be evaluated using near bottom sampling. The extent of human  impact on trace metal mobilisation in the Huelva catchment will be assessed on the sedimentary phase, using  variations of metal content and ratios and stable Pb isotopes as tracers of mine inputs.  The main characteristics of the hydrology and the sedimentology of the rivers and estuarine system will be  studied (i.e. major ion concentrations, water and sediment discharge, sedimentation rates and mineralogy).  A 3D-hydrodynamics of the Gulf of Cadiz will be implemented. This hydrodynamic model, dealing primarily  with water circulation, will be modified to incorporate the data obtained for trace metals, nutrient concentrations  and primary product
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Further developing strategic RandD cooperation with South-East Asia on ICT' (SEACOOP) under Seventh Framework.

assistant: **Objectives**

The SEACOOP project addresses the development of SandT cooperation on ICT with Southeast Asia, a region of strategic interest for the European Union. Its two main objectives are to identify, promote, and support strategic cooperation opportunities, and to support bilateral and multilateral dialogues. The project also aims at developing awareness on SandT cooperation on ICT under FP7 in Southeast Asia, and at widely disseminating project perspectives and results in the European and Southeast Asian ICT communities.<br/><br/>The SEACOOP activities build upon the achievements reached by the BASIC, ENGAGE, and GAPFILL FP6 SSAs, and will develop synergies with other programmes and initiatives similarly addressing EU-Southeast Asia cooperation on ICT. Project outputs will include:<br/> The identification of, and support to 10 to 15 key opportunities of strategic cooperation, transformed, before the end of the project (18 months), into major cooperation initiatives between the two regions,<br/> The organisation of a cooperation event in Europe and of awareness workshops in Vietnam, Cambodia, and Laos (or Brunei),<br/> The development of a web-based portal devoted to EU-Southeast Asia cooperation on ICT, part of an extensive set of promotion and dissemination activities.<br/><br/>The SEACOOP project is coordinated by Orionis, who has successfully coordinated the GAPFILL SSA. The partnership includes, on the Southeast Asian side, the national Agencies managing ICT research in the 7 most advanced countries, which, added to the fact that ASEAN has brought its support to the project, will ensure the largest participation of the Southeast Asian ICT community in project activities, and will provide a suited environment for the development of EU-Southeast Asia policy dialogues.<br/>