RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Transport and Receptor Mechanisms of Human Solute Carriers' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Human solute carriers (hSLC) form a superfamily of integral membrane proteins that transport small molecules and ions across membranes, and their transport functions are essential to processes ranging from synaptic transmission to apoptosis. Moreover, some hSLCs are the cellular receptors of human and pathogenic proteins, and play important roles in organogenesis, as well as infectious diseases.The hSLC transport and receptor functions are involved in a wide range of pathological conditions, which makes them important emerging drug targets in cancer, psychiatric disorders, and infectious diseases. Despite their paramount importance in human physiology and pathology, the current understanding of hSLCs molecular mechanisms of function and pharmacology still relies extensively on prokaryotic homologs that serve as structural and molecular models. However, due to the evolutionary divergence of these homologs, they fall short of uncovering the complexity of the hSLCs’ architectures and molecular mechanisms.Here, we aim to unravel novel transport, receptor and pharmacological mechanisms of medically important hSLCs using a multidisciplinary biophysical approach. To achieve this, we will determine the high-resolution structures of hSLCs and their macromolecular complexes with other membrane, as well as soluble proteins. Moreover, we will complement and challenge the structural data with functional approaches to probe the proteins dynamics and thermodynamics, as well as computational approaches to aid in drug discovery. Our research will expand our current molecular knowledge on the hSLCs, and aid understanding their cellular functions, as well as, uncovering their tremendous pharmacological potential.


**Keywords:** human solute carriers, membrane protein structure, membrane
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nonclassical quantum states in bec (with a tunable scattering length)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

We propose to take advantage of the intrinsically quantum nature of Bose-Einstein condensates (BEC) to create nonclassical states of matter waves, that is to say, states which cannot be described by a classical field. The first part of the project consists of directly observing number squeezing in a BEC loaded into an optical lattice, when the tunneling between adjacent wells is reduced. By using a lattice with a large separation between the sites, we plan to optically resolve each individual well and observe number fluctuations in each well below the usual sqrt(N) level, N being the number of atoms. The second part of the project consists of producing a BEC with attractive interaction between the atoms, and loading it into a double well optical potential made of two sheets of light. The system is predicted to evolve towards a highly nonclassical state consisting of a quantum superposition of all the atoms being in one well and all the atoms being in the other well. Such a Shrodinger-cat-like state is extremely fragile: we will study the sources of decoherence for a total atom number ranging from 10 to 100. These experiments are meant to open up the new field of quantum atom optics to experimental examination, and pave the way for sub-shot- noise atom interferometry and neutral atom quantum computing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Valorisation of splice-switching oligonucleotides for lung cancer therapy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Here we propose to test the therapeutic potential of a novel class of reagents, known as splicing-modifying antisense oligonucleotides, in preclinical models of lung adenocarcinoma, including patient-derived tumours in mice. Alternative splicing is a major mechanism of gene regulation by which different messenger RNAs and proteins are generated from a single gene, often displaying distinct, even antagonistic functions. Alterations in alternative splicing have been linked with a plethora of pathologies ranging from neurodegenerative disease to cancer. As a result of detailed mechanistic analyses of alternative splicing regulation in the context of the ERC-funded MASCP project, we have identified antisense oligonucleotides that modulate alternative splicing of a gene that plays key roles in the control of lung cancer cell proliferation. These reagents repress cell growth in vitro as well as inhibit tumour growth when administered intranasally in mouse models of lung adenocarcinoma. The main experimental goal of the ERC PoC proposal is to test the therapeutic value of the antisense oligonucleotides in a variety of patient-derived xenografts in mice, alone or in combination with other treatments, including chemotherapy. This will require previous optimization of dose and delivery route, which is being carried out with available support from other healthcare innovation funds. These goals are aligned with requests from various stakeholders, and funding from the ERC PoC program will be critical for successful valorisation of our assets, intellectual property protection and recruitment of venture capital to establish a spin-off company. Given the high incidence, poor prognosis and lack of efficient therapies for lung cancer, the work proposed can translate fundamental knowledge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Smart chips for smart surroundings' to be submitted under Sixth Framework.

assistant: **Abstract**

The overall mission of the proposed 4S project (Smart Chips for Smart Surroundings) is to define and develop efficient (ultra low-power), flexible, reconfigurable core building blocks, including the supporting tools, for future Ambient Systems. The aim is to establish Europe as the dominant player in the field of efficient reconfigurable architectures for ambient devices.Reconfigurability offers the flexibility and adaptability needed for future ambient devices, it provides the efficiency needed for these systems, it enables systems that can adapt to rapidly changing environmental conditions, it enables communication over heterogeneous wireless networks, and it reduces risks: reconfigurable systems can adapt to standards that may vary from place to place or standards that have changed during and after product development. It is envisaged that in the long run, work performed within this project will lay the foundations for the development of a new range of ultra low-power components, architectures, tools, guidelines and standards that underpins the future development of Ambient Systems.Main objectives for the 4S project are:- The design of a flexible reconfigurable platform based on heterogeneous building blocks such as analogue blocks, hardwired functions, fine and coarse grain reconfigurable tiles, DSPs and microprocessors that can adapt to several algorithms for Ambient Systems without the need for specialized ASICs. The concept is verified on hardware platforms. Furthermore, a digital SoC and an analogue front-end IC will be designed. The DRM (Digital Radio Mondiale) and MPEG4 applications will be implemented on the platform in order to verify the flexibility of the platform.- To provide a design flow at compile time, which reduces development time and to provide fun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Discovery and Insight with Advanced Models Of  Nanoscale Dimensions' (DIAMOND), addressing dissemination and exploitation.

assistant: **Impact**

Generating knowledge about new materials and obtaining insight in their properties at the nanoscale level are highly relevant to the scientific objectives of the EU. Here, I propose to advance the current state of the art in atomistic modeling of complex systems. I aim at providing and establishing new tools that will allow for the description of large multi-component/multi-phase systems at experimental temperature and pressure with predictive power and controlled error. Generality and ease of use will be key. Building upon my experience, I have identified two clear needs that I will address. One need is a capable implementation, i.e. suitable for large condensed phase systems, of electronic structure theories that go beyond traditional DFT. Powerful linear scaling methods with excess accuracy are essential to validate, on the complex systems themselves, the use of DFT. The second need is an automatic approach for extracting empirical models from raw electronic structure data. Empirical methods are essential to perform simulations that are multiscale in time, space, and accuracy. This automatic approach must be able to generate models beyond the intuition and patience of an individual scientist using advanced optimization methods such as genetic algorithms or neural networks. Models must have a built-in estimate of their quality. The latter feature will allow for enhancing/correcting these empirical approaches automatically with first principles calculations whenever necessary. Massively parallel computing will be the enabling technology. In line with my track record, I will establish these new methods by demonstrating their potential through challenging applications. Example applications will be in diverse fields, including sustainable energy production, catalysis, env
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'General characterisation of near term quantum advantage regimes' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Quantum computing is a very rapidly developing field with the potential to address problems that were considered intractable some decades ago. Despite the daunting technological challenge, quantum devices have reached a size for which their calculations cannot be fully simulated by classical computers. Nevertheless, noise and short coherence times hinder their actual performances, and the algorithms with proven quantum advantage will not be implemented soon.  This intermediate scenario opens exciting avenues and poses several challenges. How to systematically identify tasks where a quantum advantage over classical computers can be obtained in the near term? Once they are found, how to certify that the same computation cannot be reproduced by any classical means?ENCHANT, gENeral CHAracterisation of Near-Term quantum advantage regimes, proposes a radically new vision: the development of a comprehensive toolset to characterise the remarkable realm of near-term quantum advantage regimes. The toolset is meant to provide three fundamental assets for such an ambitious task: (A) a general framework encompassing the algorithms that can be run in current devices, compatible with their main limitations and constraints. We envision to obtain that by means of a careful  classification of the families of states that can be obtained as the output of near-term quantum computation, (B) an assortment of task-tailored classical algorithms to simulate the performances of quantum devices. Here the interest is two-fold: to provide comparative methods to assess the quality of those devices and to identify tasks with no quantum advantage over classical computers, (C) a selection of techniques to certify quantum effects in computation and relating them to the hardness of simulating the same tas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Paleo-ecogenomics in Daphnia: developing a model for studying evolutionary impacts of climate and environmental change', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

PALECOEVOL is a highly multidisciplinary study combining population genomics with paleoecology, and is firmly embedded in the theoretical framework of evolutionary ecology. This transformative research is based on the direct observation of evolution in the past 2000 years in the highly endangered Arctic environment. By recording population genomic parameters before and after environmental shifts, a pioneering dataset unprecedented in genomic detail will be supplied and rigorously combined with historic environmental data. The overarching goal is to study, across millennia, the genomic responses of the ecological and genomic model organism Daphnia, an aquatic keystone herbivore, to repeated shifts in temperature and related environmental parameters, and to lay the foundation for establishing a novel model system to study the effects of environmental change at the population level. This and future work will transform our current understanding of the magnitude and the constraints of population adaptation to the rapid environmental changes our planet is now facing. The overall impact of this fellowship results from cross-fertilizing the gained ecological and genomic expertise with training the prospective fellow in its application towards environmental regulation and policymaking that will qualify her to provide leadership for academics and legislators alike.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Science promotion in Bistita-Nasaud county'.

assistant: **Objectives**

Science plays a major role in the development of a society. Despite this, the general population of Romania has little knowledge about the impact of research on all aspects of life. In this context, events that advertise science among the general public are very welcome. Another strong argument in favour of organising the science popularization event in Bistrița is that this kind of events usually take place in major cities, while in small and medium towns they are very rare, so their population is missing the opportunity to discover science from a different perspective; in turn, this lack of information facilitates the occurrence of stereotypes about scientists and their work and about the usefulness of scientific research, which ultimately discourages young people to pursue a career in R&D.The main concept proposed for 2020 is to reduce the passive presentation of what means to be a researcher, by involving the people directly in different interactive activities (workshops, games, competition, debates etc.). The project is constructed around three basic ideas: Future through past; Health and wealth through a clean environment; Economic development of the county through technology and innovation.An important objective is also the future utilization of information gathered during the event, in order to enable cooperation between relevant actors that are committed to support scientific collaboration that may generate new opportunities for research and industry and new knowledge and know-how that can be shared by confronting new ideas and viewpoints.Regarding the audience, the Dissemination Strategy will be directed towards various user groups, such as: the general public, especially young people, the scientific community, public institutions, NGOs, policy-makers, various
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Efficient exciton dissociation/formation in supramolecular semiconducting polymer morphologies - demonstration of the fabrication of efficient electroluminescent and photovoltaic devices' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

We propose a basic research study of mechanisms and conditions required for efficient dissociation/formation of excitons into (from) free charges in organic multilayers and the relation to the morphological parameters of the materials. In the first instance we will concentrate on studying the mechanisms referred to above and the dependence on the electronic structure of monomers, oligomers and specific molecules like C60 and TCNQ. From these basic studies we hope to ma judicious choices of systems which can be tested for device applications. For this a basic research study of the influence the morphological parameters is of great importance since these are known to strongly influence the efficiency of processes New in this proposal are the use of modern molecular beam epitaxy techniques to grow very well defined organic (multi)layers as well as the specific behavior and morphology of block copolymers combined with an in situ study of their electronic structure electrical transport and optoelectronic properties. Knowledge obtained here will be coupled back to the synthesis of new oligomers, monomers and polymers with the hope of further optimizing properties and for a directed effort in the development of multiblock copolymers incorporating all of the required functions for a device. Also judiciously chosen systems will be further studied with regard to the morphology as mentioned above. The development of efficient photovoltaic and electroluminescent devices is one of our long-term targets. Training content (objective, benefit and expected impact) The candidate has an excellent knowledge of and training on the structure of solid state polymers and polymer morphologies. Her involvement in the proposed project will enlarge her knowledge and skills on the functional (photo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Space-based SST (mission, system and sensors network) Horizon Europe TOP3'.

assistant: **Objectives**

This Horizon Europe grant is to be understood within a wider context on EUSST, where other grants are being executed simultaneously with the common objective of improving the EU autonomy on Space Surveillance and Tracking.In particular, this TOP focuses on:- Study and assess several technical solutions for the development of a future European capability of SBSS. - Explore the use of small satellite solutions to reduce CAPEX and OPEX - To develop in the mid-term the European capacity to operate independently SBSS. - To reduce the dependence on critical SBSS technologies and capabilities from outside Europe,The is the first activity related to SBSS within EUSST.


**Keywords:** EUSST, SST, Partnership, Front Desk, Services, Assets, Sensors, Radars, Telescopes, Lasers, Catalogue, Users, Collision Avoidance, Re-entry, Fragmentation, Survey, Tracking, Autonomy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A Non-Surgical Treatment to Restore Heart Valve Function' to be submitted under Horizon 2020.

assistant: **Abstract**

CroíValve is an innovative SME with the mission to lead the treatment of tricuspid valve disease and transform the lives of patients who currently face certain death. In the US and EU, 550,000 patients present with tricuspid valve disease annually. Current treatment involves highly invasive, risky open-heart surgery and <1% receive this due to the risks involved. Recent clinical data is highlighting that the ""forgotten tricuspid valve"" must be treated. CroíValve has developed a non-invasive device uniquely tailored to the challenges of the tricuspid valve. It is a small device that is delivered through a vein into the right heart, restoring the function of the tricuspid valve. Invented by a leading cardiologist, and refined by expert biomedical engineers, CroíValve’s is a non-surgical, safe, effective, easy to use solution for treating all patients with TR.  It will transform patients’ lives, provide physicians a safe and straightforward treatment option and reduce the hospitalisations. There is a significant market potential of > €2.5Bn/year. With H2020 SMEi funding, this Phase 2 Innovation Proposal will support the activities necessary to complete clinical trials and demonstrate safety and efficacy for CE Mark approval. Securing this grant, alongside private funding, will enable the company to expand its manufacturing capabilities, build up its sales and marketing infrastructure. CroíValve’s management team have a successful track record in the development, patenting and commercialisation of medical devices who can position the company as a leader in the treatment of tricuspid valve disease.""