RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Braid groups and the jones polynomial in arbitrary 3-manifolds' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The project is concerned with the construction of Jones-type invariants of knots in arbitrary 3-manifolds using and developing algebraic techniques analogous to Jones' original ones for the 3-sphere. It continues my current HCM project, in which I succeeded in constructing all such knot invariants in a solid torus, and then extended this construction to the lens spaces L(p,l) (as it had been proposed). For extending the construction to arbitrary 3-manifolds, the following has been done: I have established the necessary knot-theoretical background as well as the existence of associated braid structures in 3-manifolds, and also proved braid isotopy theorems. The method used for L(p,l) seems to be the appropriate one for resolving the problem in the general case. one of the objectives of the project is to provide a unifying understanding of the Jones-Witten theory in 3-manifolds. As this is a proposal for a Return Fellowship, I wish to add that in parallel to my research project I plan to set up in Athens a postgraduate course in Knot theory, the Jones polynomial and its connections to Statistical Mechanics and Biology. I shall also give a seminar series on my research work and organise a Low-Dimensional Topology conference in Greece (with Professor V.F.R. Jones as a co-organiser).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Bss/blc_2002'.

assistant: **Innovation**

The scientific objective of the Baltic Summer School 2002 (BSS-2002) is to offer scientific information at the highest possible level on the topic Signalling in Muscle Metabolism". The course will give a deep insight into methods used in modern muscle research, a deep understanding of the fundamental aspects of regulation in muscle metabolism, as well as application of this knowledge to prevent and/or treat diseases like obesity, type II diabetes, the metabolic syndrome and muscle atrophy in the aging population. These diseases currently burden mankind and have a large socio-economical impact on modern society. The scientific objective of the Baltic Lab Course 2002 (BLC-2002) is to offer laboratory experience related to the abovementioned topic. The course will give a deep insight and hands-on experience into methods used in modern muscle metabolic research. It is intended as a continuation of the Baltic Summer School 2002, which provides deep theoretical insight into the topic and the way knowledge in this field can be used to prevent and/or treat diseases like obesity, type II diabetes and the metabolic syndrome.Thus, the Baltic Summer School 2002 (BSS-2002) and the Baltic Lab Course 2002 (BLC_2002) addresses a wide scientific community, from researchers in basic sciences to physicians working in clinical research. The rapid technological development in the field of signalling in muscle metabolism and the large socio-economical impact of the disease states related to modern life style and characterized by abnormalities in muscle metabolism makes this summer school particularly important and relevant."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Increasing metabolic engineering efficiency using a conditionally quiescent fission yeast mutant'.

assistant: **Objectives**

The proposed project aims to solve a major challenge in metabolic engineering. In microbial metabolic engineering platforms, consumed nutrients are primarily invested into population growth instead of the production of chemicals of interest. Our team is studying a temperature-sensitive mutant of fission yeast (Schizosaccharomyces pombe), which grows normally at 26°C, but enters quiescence at 36°C, while at the same time maintaining its metabolic activity. Such an engineering platform could represent the holy grail of the metabolic engineering field - a chassis strain that can stop growing but keeps producing metabolites. Application of such pseudo-quiescent strain would be useful to both industrial and academic players. To develop this mutant into a new metabolic engineering chassis, I will first design a molecular cloning toolkit to perform metabolic engineering in S. pombe, which will enable construction and expression of complex biosynthetic pathways. Second, I will characterize the phenotype of the pseudoquiescent S. pombe mutant using a multi-omics approach. I will generate knowledge about mRNA, protein, metabolite and flux dynamics to delineate a genome-scale metabolic model of the chassis under pseudo-quiescence. Then, I will assess the ability of the S. pombe mutant to overproduce 3 different high-value compounds (kavain via phenylalanine, theophylline via purine and artemisinin precursor via mevalonate). Finally, I intend to reproduce the pseudo-quiescent mutant phenotype in other commonly used yeast species (Saccharomyces cerevisiae and Yarrowia lipolytica). In the short term, this research will deliver a new type of a metabolic engineering chassis for the production of complex chemicals to the metabolic engineering community. In the long term, it will contrib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Photonic Spectrum Analyzer for the Terahertz Spectral Domain' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Scientific and commercial utilization of the Terahertz spectrum (100 GHz -10 THz) is often hindered by the lack of affordable characterization tools for developing systems towards maturity. This proposal aims for the prototype development of such tools, namely  affordable spectrum analyzers (SA), in order to boost component development in the Terahertz domain (100 GHz-10 THz), particularly electronic and opto-electronic components. These are employed in 6G hardware, spectroscopy including bio-medical trace gas detection, security, non-destructive testing and quality control. To date's most employed systems are electronic frequency-extended microwave SAs. Whilst very powerful, they have a few draw backs:1.) it is very challenging to develop electronic systems for higher THz frequencies. The highest commercial frequency extension to date goes to 1.5 THz.2.) the higher the frequency, the exponentially more expensive are the frequency extenders.3.) The extender modules are bound to specific waveguide bands. Spectra larger than 50% of the center frequency can only be obtained by employing several extender bands.In PhoSTer THz, we will implement a photonic spectrum analyzer system as opposed to electronic ones, with the following advantages:1.) Spectral coverage from microwaves to several Terahertz with a single system without the need of exchanging bands.2.) Accessing frequencies yet not accessible with commercial electronic systems3.) Inexpensive solution: a single photonic system costs less than the electronic base unit (i.e. without extenders)PhoSTer THz emerged from the ERC grant Pho-T-Lyze (GA 713780) where the first versions of photonic spectrum analyzers were developed. In PhoSTer THz, we will bring the first prototypes close to market entry together with powerful com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Enhancing natural wastewater treatment systems: the role of particles in sunlight-mediated virus inactivation' (PARVIRDIS).

assistant: **Innovation**

The processes by which viruses are inactivated in sunlight-exposed surface waters remains largely unknown.  This lack of information severely limits our ability to predict the efficiency of and rationally design natural treatment systems that utilize sunlight-mediated inactivation (e.g., constructed wetlands). Viruses commonly associate with particles in surface waters, including photoreactive particles that can 1) adsorb viruses and 2) produce reactive oxygen species (ROS) when exposed to sunlight.  Virus adsorption onto the surface of photoreactive particles exposes them to elevated ROS concentration and may increase inactivation compared to free viruses.  The goal of this research is to characterize the adsorption and inactivation of particle-associated viruses in the dark and exposed to sunlight, with the aim of predicting the fate of viral pathogens within natural systems and using this information to improve their efficiency.  We will quantify how different viral characteristics (e.g., isoelectric points, capsid size and composition, genome type) influence adsorption and inactivation, and which modes of inactivation are dominant (e.g., ROS damage to viral host binding sites, destruction of viral capsids by ROS or adsorption, and modification or destruction of genomic nucleic acids by ROS or nucleases).  To aid in this study, a novel qPCR-based method for determining virus viability will be developed, a tool that will be of use for a variety of fields including environmental microbiology, public health and medicine.  The detailed information gathered in this study will then guide the development of methods to improve the viral removal efficiency of a highly controllable constructed wetland.  Different wetland configurations will be tested to promote virus adsorptio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mapping and Direct Sequencing of the Non-Canonical Cap Code' (MaDCap), addressing dissemination and exploitation.

assistant: **Impact**

From their creation to their degradation, mRNAs are under extensive regulation. This regulation is directed not only by their nucleotide sequence and their promoter but also by post- and co-transcriptional modifications attached to the RNA. One of the most ubiquitous of these modifications in eukaryotes is the 5' cap  typically a methylated guanine (m7G) attached inversely to the first transcribed nucleotide. Several decades of research have revealed the m7G cap as an interface for regulating stability, splicing, polyadenylation, localization, and translation. The m7G cap was long presumed to be the only functional cap in eukaryotes, but this view was recently overturned by the discovery of the non-canonical nicotinamide adenine dinucleotide (NAD+) cap. Following this, several other eukaryotic cap structures were discovered: NADH, flavin adenine dinucleotide (FAD), uridine diphosphate glucose (UDP-Glc), and uridine diphosphate N-acetylglucosamine (UDP-GlcNAc). The function of most non-canonical caps is unknown, but their presence suggests the existence of a regulatory cap code.Currently, the complete cap structure can only be identified through bulk methods that cleave caps from their transcripts, thereby losing the link between mRNAs and their specific caps. For NAD-caps enrichment techniques exist that can be followed by sequencing, but no such method exists for other non-canonical caps, and no sequencing method exists that can identify more than one cap. This limitation is a significant obstacle in understanding the cap code and the function of its more enigmatic members.The objective of this project is to 1) develop a novel single-molecule method that can directly sequence native caps with their full-length RNA transcripts, 2) use this method to characterize the cap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Engineering a living human Mini-heart and a swimming Bio-robot' in the context of a Horizon Europe call.

assistant: **Objectives**

Cardiovascular disease (CVD) is still the N1 cause of death worldwide despite the significant efforts of academia and pharmaceutical industry to understand the different underlying causes of CVD. They have been hampered by the lack of proper human cardiac models as the animal models have different physiology and gene expression from the human situation and the flat cell culture in vitro models are not capable of producing pumping motion, which is the main function of the heart. Furthermore, pesticides toxicity and risk for human health are controlled at a European level through a well-developed regulatory network, however, cardiotoxicity is not described as a separate hazard class while it can have long-term cardiovascular complications. Here we propose to make better predicative in vitro cardiac models by making a vascularized beating mini-heart and a self-propulsion swimming bio-robot made by assembling human cardiac cells into 3D tissue structures using sacrificial molding and high-resolution 3D bio-printing. The mini-heart and the bio-robot will enable the scientific community to have a more realistic human cardiac model in vitro and a proper tool to assess the presence of cardiotoxicants in the environment. This work will be done in a consortium of four parties with the necessary expertise, ranging from heart development, human pluripotent stem cells, 3D bioprinting, tissue engineering and biosensing, to bring these engineered living tissues to reality.


**Keywords:** Human induced pluripotent stem cells, cardiac, 3D bioprinting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced Nickel-Titanium Alloys for Medical Device Applications' (MEDALLOY).

assistant: **Concept**

MEDALLOY is an Industrial Doctoral Network that will provide world-class interdisciplinary and intersectoral training to 9 Doctoral Candidates (DCs) through an international consortium across 6 countries. Nitinol is a unique material with remarkable superelastic and shape memory properties and is critical for innovative cardiovascular devices, addressing the healthcare needs of Europe’s aging population. MEDALLOY targets key challenges identified by our industry partners through its research objectives: develop superior Nitinol alloys with enhanced performance; optimise manufacturing processes to control material microstructure; advance defect tolerance and fatigue life prediction; and create validated simulation tools. MEDALLOY combines the proven expertise of its consortium members, cutting-edge industrial-scale facilities, and an ambitious research plan to push Nitinol research beyond the state of the art, enabling the next generation of Nitinol medical devices and opening possibilities for new innovative solutions. Supported by the industrial participants from across the medical device value chain, all DCs will develop a clear roadmap for commercialisation and exploitation of their research. Our innovative scientific methods, built on key recent patents and publications from across our consortium, will provide an excellent training environment for the 9 high-achieving DCs. Our comprehensive training plan, including network-wide and local actions, will build on the research-based training and include contributions from our clinical, industrial, and academic participants. In addition to technical research training in all stages of the medical device value chain, MEDALLOY will deliver interdisciplinary training to DCs in clinical trials, ethics, sustainability, communi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel concept of a low cost, high power density and highly efficient recyclable motor for next generation mass produced electric vehicles' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

HEFT considers that an energy efficient rare-earth synchronous motor is the best option for next generation high-power primary axle traction EVs and proposes a set of innovation challenges on electric synchronous motor configuration based on SiC inverters (direct cooling of rotor and stator, advance insulation for high voltage, multibarrier rotor topology, wave windings) and advanced materials (advanced GBD magnets, epoxy for magnet fixation, composite for motor housing, insulation resin).These innovations will result in a high-efficient and low-cost solution that will be validated on 2 motor topologies, which compared to two main reference automotive IPM commercial motors in Europe (VW ID.3 and FIAT500) will lead to next impacts: >800V, 20% reduction losses, >7 KW/kg and 42kW/l power density, 28% cheaper, 50-66% material savings, including 60% reduction of REE content and >80% REE recyclability rate.As this solution is still dependent on REE from China, HEFT will be aligned with the ERMA action plan towards a circular economy market of rare earth permanent magnets and suggests: one alternative magnet route (Ce based) and two REE recycled routes together with policies promotion towards the foundation of a European rare earths industry, capable of delivering 20% of EU demand by 2030.HEFT plans 8 WPs to implement these concepts, where 5 research partners will be essential for developing innovative ideas around the design-to-x approach, while strong companies (GKN, MAGNETI, VYNCOLIT) will ensure that HEFT results have a clear market orientation and fulfil the industry needs.HEFT plans to organise OEM workshops to ensure wide adoption of HEFT solutions, but also with policymakers to promote regulations towards the EU circular market that would help maintaining the leadershi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A Novel Loop-Heat-Pipe (LHP)-based Data Centre Heat Removal and Recovery System Employing the Micro-channels Cold/Hot Plates'.

assistant: **Objectives**

Date centres consume 1.1-1.5% of the world’s total electricity supply and remain 15-20% of annual increase rate in power demand. Space cooling, owing to vast dissipation of the heat from the data-processing equipment to data centre space, has a very high cooling capacity, accounting for 30-40% of energy delivered into the space. Developing an effective heat removal and recovery system to prevent excessive equipment heat transmission to the space is critical to reducing energy consumption of the cooling system. The proposed MSCA programme aims to investigate an innovative a novel Loop-Heat-Pipe-based data centre heat removal and recovery system employing the micro-channels-cold/hot-plates(LHP-C/H-PLATE-4-DC), by integrating the excellence of the host applicants in loop-heat-pipe(LHP) and expertise of the researcher applicant in hot/cold plates for data processing equipment. The innovative features of the system lie in (1) microscopic interior spaces increase liquid evaporation rate and heat transfer of the LHPs; (2) sensor-controlled liquid upper-feeding and liquid/vapour separator prevent the dry-out and entrainment effects of the conventional LHPs; (3) flat-plate surface of the cold-plate enables a perfect contact with the skin of the data-processing equipment; and (4) novel heat/mass transfer analysis approaches employing the latest fractal and enthalpy/temperature-difference-driven heat transfer theories. The programme tasks include (a) concept development; (b) computer modelling; (c) prototype construction & testing; and (d) economic & environmental analyses. The programme will attract an experienced researcher with particular knowledge in data centre heat removal technologies into Europe. This will (a) achieve transfer of knowledge from outside into Europe, thus he