RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Crystallisation Systems Engineering –  Towards a next generation of intelligent crystallisation systems' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The project proposes the development of an intelligent crystallisation system by combining state-of-the-art process analytical technologies and novel model-based and statistical feedback control approaches, to provide a fully integrated and adaptive system for efficient engineering of particulate products. The developed adaptive and robust control approaches will be incorporated in a Crystallisation Process Informatics System, to provide an intelligent decision support system, which triggers the suitable control algorithm taking into account the effect of crystallisation on the downstream processing units and final product properties. In this way crystallisation becomes a key intelligent “process actuator” in the whole production system, that manipulates final properties of the solid product taking into account operational, regulatory and economic constraints of the entire process, opening the way towards novel product engineering approaches. The project will bring the implementation of a new generation of integrated, intensified and intelligent crystallisation systems with drastically improved flexibility, predictability, stability and controllability. The system will be used for detailed evaluation of the current paradigm shift from batch to continuous processes in the pharmaceutical industries. Besides providing a breakthrough in crystallisation science the results could revolutionise the methods in which crystallisation will be designed and controlled in the future, yielding to the development of the emerging research field of Pharmaceutical Systems Engineering, by providing a comprehensive framework for the development of novel integrated pharmaceutical production units and product engineering technologies, for sustainable pharmaceutical production, with the aim of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Surveillance mechanisms regulating nuclear envelope architecture and homeostasis'.

assistant: **Concept**

The nuclear envelope (NE) is a major hub of eukaryotic cellular organization, influencing a myriad of processes, from gene regulation and repair to cell motility and fate. This central role of the NE depends on its elaborate structure, particularly on the organization of its inner nuclear membrane (INM). This peculiar membrane is continuous with the rest of the endoplasmic reticulum (ER) but faces the nucleoplasm and contains a distinctive set of proteins, which confer a unique identity to the INM. Importantly, mutations in several INM proteins result in a wide range of diseases, such as muscular dystrophies and premature aging syndromes, highlighting the key roles of the INM proteome in cell homeostasis. However, the mechanisms establishing and maintaining the INM proteome identity and integrity have remained mysterious. My lab recently identified a quality control system that, by targeting aberrant proteins for degradation, regulates INM identity and homeostasis. This proposal describes a framework to expand our findings and to provide a comprehensive and integrated understanding of the INM proteome. By combining my expertise in membrane protein analysis with newly developed proximity biotinylation and proteomics approaches, we will for the first time probe the complex INM environment of living mammalian cells. A systematic examination of the INM proteome, its turnover rates and changes in response to different physiological conditions will reveal functions of INM proteins and their regulatory pathways. Moreover, it will characterize INM surveillance mechanisms and evaluate their contributions to NE proteostasis. In sum, this proposal will provide a panoramic yet detailed view of the mechanisms underlying INM functions, identity and homeostasis, both in interphase and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nano-particles: their application in the development of electrochemical molecular beacon biosensors' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Affinity biosensors, due to their selectivity, sensitivity and the fact they can be developed in a reagent-less and reusable format, find large application in environmental and clinical analysis. Key elements in biosensor development are: (i) the electrode surface (transducer) chemistry/properties, (ii) the recognition element and (iii) the signal generation element.  In this proposal electrodeposition of nano-particles will be investigated as a way of modifying the transducer (electrode) chemistry/properties in order to improve/optimise the performances/layout of electrochemical molecular beacon biosensor.  Several applications of RnEs will be investigated.  · RnEs as a possible route to improve biosensors sensitivity (due the intrinsic catalytic properties of the nano-particles) · RnEs as a way generating specific attachment sites suitable for the recognition element. · Nano-particles as physical masks (template) for patterning, at nano size level, self assembled monolayer (SAM) of thiolated molecules onto Au surface (definition free sites, suitable for the recognition element attachment, in an antifouling matrix).  Furthermore the influences of nature of the redox centre over the performances of electrochemical molecular beacon will be investigated in this proposal. The knowledge generated will be applied to the realisation of electrochemical molecular beacon DNA sensors for the prenatal diagnosis of Cystic Fibrosis and Thalassemia two of the most common genetic diseases. These areas of application have been chosen because of the relevance of the two diseases and because of the necessity to simplify the pre natal diagnosis of them that currently is performed with invasive, costly and risky procedures such as amniocentesis and “chorionic villa sampling”.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Customizable Hyperguide To Cultural And Scientific Webs' to be submitted under Fifth Framework.

assistant: **Abstract**

Initiative to take up an interactive push application, which provides an interpretative dynamic storyboard based on a customisable methodology for web description. The application will be: dynamic, in the sense that it allows to be easily modified; interpretative, in the sense it will accommodate information items in XML metrical documents; interactive and searchable in a query oriented context.Objectives:The objective is to provide a tool to build customisable hyper guides to cultural and scientific webs. It aims at developing an interactive push application that provides an interpretative dynamic storyboard based on a customisable methodology for web description (CUM). The software application will be designed and implemented in the up-to-date XML architecture. This hyper-guide addresses the need of improving web access, selection and filtering and usability of information resources in specific domains.Work description:The hierarchies of nominalistic listings as well as database paradigms are not completely suitable to the Internet information universe. In order to increase the web usability a new XML-based template model is needed to structure and record webs. Qualified support comes from the legacy of information studies, which have developed the ability to extrapolate the information elements from heterogeneous information materials of different nature, to reorganize these elements in complex value added and dynamic systems and to proactive disseminate and communicate the results into a knowledge process. The tool will be an interactive push application, which provides the template to build a storyboard in XML to facilitate identification of selected websites of heterogeneous or homogeneous nature. It will make use of the CUM methodology developed and tested in sci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Supporting innovation in traditional companies' (TRADINN).

assistant: **Concept**

Innovative solutions are often combined with companies operating in the modern technologies industry, highly automated production companies or start-ups launching products and services based on the latest research and discoveries. Meanwhile, the market is dominated by companies offering traditional solutions that do not show, at first glance, the perspective of transformation towards broadly understood innovations. The belief in the lack of development opportunities by implementation of significant changes in traditional businesses is the reason for the stagnation, shrinkage and even the collapse of many SMEs in Europe.Traditional companies are enterprises operating in industries that have been operating on the market for several dozen or even several hundred years, e.g. agriculture, forestry, construction, gastronomy and hotel industry, education, legal or accounting activities, as well as the activities of libraries, archives, museums and various types of transport services. The degree of their modernity and approach to the implementation of innovation often opposes modern industries related to broadly understood digitalisation and based mostly on the latest knowledge, such as IT, IoT, AI, AR, VR, drone industry, telemedicine or even hydroponics in favor of these others, of course.Although effective combinations of innovations with traditional services or products, such as thermoactive clothing, on-line food stores, train simulators or foot scanners in shoe stores are already well known, entrepreneurs' willingness to develop towards new technologies is still small. The reason may be the lack of awareness of existing solutions and technological possibilities. The goal of the project is to develop a strategy for promoting innovation in such business, that could be imple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ST PIERRE ET MIQUELION WIND DIESEL REMOTE INSTALLATION', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

To install a 1.8 MW wind farm consisting of six 300 kW turbines on a remote island location, without conventional crane erection techniques. To demonstrate diesel fuel savings for the existing diesel generation facility. To build on the experiences of the 2.7 Dunkerque wind farm project by continuing the development of the Francisation of the WindMaster 300 kW turbine, by successful integration of French manufactured components. Redesign of existing turbine technology to facilitate shipment by means of standard containers i.e. a self-contained unit for application in remote regions. Design and implementation of self erection technology for application in remote regions. Delivery of advanced control and inverter technology for wind-diesel hybrid systems for application in remote regions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Atrc - tetra' to be submitted under Fifth Framework.

assistant: **Abstract**

As a continuation of a previous series of Eurconferences, the objective of the proposed series of High-Level Scientific Conferences is to promote cross-cultural translation research and research groups by measures that will facilitate the creation of joint European translation PhD programs and will eventually lead to a network of translation competence centres in Europe (esp. including the associated states in middle and Eastern Europe). For this reason, it is planned to stage the conferences at three European venues (Charles University, Prague, Aarhus Business School, Aarhus, and Saarland University, Saarbrücken) that are representative for the research done in relation to the three interrelated topics of the series. In addition, the conferences will enhance the international transparency of research results in translation and promote the mobility of researchers in the field.The three conferences will deal with the overall topic of 'Text and Translation' and will feature three perspectives: 1) Modes and parameters of describing the internal structure of texts and its transfer modi from a source culture to a target culture (first event Textology and Translation", venue: Prague), 2) the interaction of texts with the world in terms of the interrelationship of the established parameters with presupposed world knowledge systems in texts, its representation and translation (second event 'Knowledge Systems in Text and Translation', venue: Aarhus), 3) The possibilities for systematizing these relationships with a view to establishing a (computer-aided) theory and methodology for the translation of texts (third event 'Translation Theory and Methodology', venue: Saarbrücken). The conferences deal with the general question to what extent human translation decisions (with respect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enabling Best Practices For Oncology' in the context of a Fifth Framework call.

assistant: **Objectives**

The BEPRO project aims to provide five influential centres of cancer specialists, each at the heart of a Regional, National or European network, with resources to extend their current pilot use of results from previous European projects in Information Technologies for Health. They will deploy additional applications, integrate them within their centre's current environment, and receive training. The resulting best practice will then be demonstrated in use. Results will be disseminated to the relevant European medical community and, when applicable, submitted to standardization bodies.Objectives:The BEPRO project will demonstrate best practice in action enabled by the use of innovative telematics applications in Oncology. Five influential centres, each at the heart of a Regional, National or European network of cancer specialists, will experiment these telematics applications for sake of integration in the centres' working environment. Co-operative services will allow sharing experiences between experiments in order to reach consensus at inter-application and trans-national levels. Results will be disseminated to the relevant medical community and will be submitted, whenever applicable, to standardization bodies. Since the project will deal with data exchange procedures based on XML and DTD kept at the most generic and re-usability levels, the project may act as a co-ordinator of other projects dealing with state-of-the-art data exchange technologies independently of the medical application.Work description:The BEPRO project will follow 3 successive phases to reach its main objectives.The SETUP PHASE is aiming to secure the medical evaluation in order to limit the possible negative impact of performing evaluation from technically non-optimal implementations. During this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dissect cargo selectivity in autophagy' under Horizon Europe.

assistant: **Concept**

(Macro)autophagy is an evolutionarily conserved catabolic process induced to preserve cellular homeostasis under conditions of stress, such as nutrient starvation. Upon autophagy activation cellular components are engulfed by autophagic vesicles, which then fuse with lysosomes for substrate degradation. Despite the unquestionable physiological and medical relevance of nutrient- and pharmacological-induction of autophagy in human health, the precise identity of autophagy substrates and the rules governing their selection in vivo are largely unknown. AUTO-SELECT’s goal is to provide a framework to identify physiologically relevant autophagy substrates in different organs and to determine the signaling events that govern their selection. This proposal relies on (1) newly generated mouse models to genetically manipulate autophagy and key autophagy regulators, (2) tools to quantitatively measure autophagy substrate delivery to lysosomes and subsequent degradation in vivo, and (3) -omic technologies and bioinformatic tools to dissect the molecular events that govern substrate selection in response to diverse stimulations in a tissue-specific manner.  In addition, AUTO-SELECT will develop new strategies to modulate selective autophagy and test their therapeutic relevance in connective tissue disorders characterized by the intracellular accumulation of misfolded procollagen molecules. AUTO-SELECT has the potential to discover new rules governing cargo selectivity during autophagy and, hence, to provide new links between energy metabolism and cellular quality control that might be exploited for autophagy modulation to treat human diseases.


**Keywords:** autophagy, selective autophagy, lysosome, nutrient sensing, mTOR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Safe-, sUstainable- and Recyclable-by design Polymeric systems - A guidance towardS next generation of plasticS' (SURPASS).

assistant: **Concept**

Plastic waste outlive us on this planet as they take centuries to break down. Endocrine disruption, land, air and water pollution are only some of the adverse effects of plastic waste on public and environmental health. Still, 70% of plastic waste collected in Europe is landfilled or incinerated.The overall objective of SURPASS project is to lead by example the transition towards more Safe, Sustainable and Recyclable by Design (SSRbD) polymeric materials. The SURPASS consortium of 14 partners consisting of research and technology organizations and industries will:1. Develop SSRbD alternatives with no potentially hazardous additives through industrially relevant case-studies (TRL3-5) targeting the three sectors representing 70% of the European plastic demand:- Building: bio-sourced polyurethane resins with enhanced vitrimer properties to replace insulating PVC for window frames (? 40% C-Footprint reduction)- Transport: lightweight, therefore less energy-consuming epoxy-vitrimer (? 30% C-Footprint reduction), as alternative to metal for the train structure, anticipating emerging use of non-recyclable composites.- Packaging: MultiNanoLayered films involving no compatibilizers to replace currently non-recyclable multi-layers films (? 60% C-Footprint reduction).2. Optimize reprocessing technologies adapted to the new SSRbD systems to support achievement of ambitious recyclability targets.3. Develop a scoring-based assessment that will guide material designers, formulators and recyclers to design SSRbD polymeric materials, operating over the plastic?s entire life cycle, including hazard, health, environmental and economic assessment.4. Merge all data and relevant methodologies in a digital infrastructure, offering an open-access user-friendly interface for innovators.SURPASS