RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Next Generation Sequencing to Identify Genes Underlying Extreme Psychiatric Illness and Extraordinary Cognition' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The goal of this research is to use next generation sequencing (NGS) to identify genes that have pronounced, early-onset effects on specific cognitive and psychiatric processes by sequencing children with exceptional cognitive abilities or exceptionally early onset psychotic illness. Mental disorders present an enormous societal burden, largely because of our inability to effectively treat them.  An improved understanding of their genetic basis could lead to the identification of novel drug targets and improved treatments. Unfortunately, genetic analysis of common neuropsychiatric disorders such as schizophrenia, bipolar disorder, epilepsy, autism and ADHD suggests that they are very genetically heterogeneous, and very large sample sizes will be needed to gather statistical evidence for individual genes and variants. However, there is also evidence for a considerable genetic overlap between different neuropsychiatric traits, suggesting that identifying key genes underlying any neuropsychiatric or neurocognitive process could potentially benefit the entire class of disorders. My program of work seeks to identify genes underlying both pathological and non-pathological traits that: (i) represent the extreme of a particular neurocognitive domain, and (ii) onset very early in childhood before any known environmental contributors would be expected to have much impact. The underlying hypothesis is that in some cases these traits are caused by a single genetic variant that can be identified by comparing the genomic sequence of the affected and unaffected family members. During the period of reintegration to the UK that is supported by the requested funding (2014-2018), I will focus my research program on childhood onset schizophrenia, and exceptional early-onset mathematical an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'The Merging of Innovation Management Techniques in Norway'.

assistant: **Innovation**

Project Innovation Management Techniques - IMT" in Norway aims at helping SMEs to strengthen their long-term business prospects through innovation management consultancy assignments by :developing a common agreed and tested approach combining experience from former programmes and projects in Norway.Training 12 consultant in the methodologies which are based on BUNT and FRAM techniques but also include tools which deal with:- integrated processer with customers and suppliers- Production improvement- Process development- Process simplificationCarrying out 35 company assignments.Producing written training material suitable for presentation in broader areas.Organising regional meeting to spread the results.Disseminating the experience both on a national and European level."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Kinetic Pathways to Control Nanocrystal Shapes' (2021-2027) under Horizon Europe.

assistant: **Objectives**

The shape of nanocrystals is crucial in determining surface area, reactivity, optical properties, mechanical strength, and self-assembly behavior. The current theory on shape formation is based on thermodynamic equilibrium and predicts that each crystal structure should enforce a unique shape, with few morphological variations depending on solution chemistry. Whereas this theory succeeded in explaining crystal habits in mineralogy, it mispredicts many nanocrystals, pointing out the necessity of a non-equilibrium description of shapes. Critical to this project are robust and scalable simulation techniques that capture kinetic effects of ligands and ions in solution at the atomic/molecular scale, while enabling the formation of facets and shapes at mesoscopic scales. Research questions include understanding (i) kinetically trapped shapes in metastable equilibria, (ii) symmetry-breaking from the underlying crystal structure, (iii) the bifurcation of growth pathways leading to synthesis yield, (iv) the emergence of chiral and asymmetric features, and (v) the role of the concentration field in the solution. Central will be the finding of shape diagrams that pinpoint thermodynamic conditions and kinetic factors to tune crystallographic direction and surface area of facets with maximum synthesis yield. Shapes of interest include classic polyhedra, 1D and 2D geometries, multiply twinned particles, concave and high Miller index facets, and branched shapes. This project will allow theory- and computer-aided design and optimization of synthesis protocols of nanocrystals with kinetic shapes.


**Keywords:** nanocrystal shape, crystal growth, crystallization-diffusion, mass transfer-limited crystallization, kinetic Monte Carlo, molecular dynamics, simulation method development, mult
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'It’s not my fault I am aggressive, they picked on me: How early peer relations affect DNA methylation and neurocognitive development in children'.

assistant: **Innovation**

Think about the day you took your child to kindergarten for the first time. You were worried. Worried about the social experiences of your child. Would peers like your child, or would it get bullied, or rejected by classmates? Many children have positive social school experiences, but 10-15% of children become rejected, victim of bullying, have few friends and have poor relations with teachers. Such experiences have been linked to aggression development, but we poorly understand how.I hypothesize that adverse social experiences in kindergarten and elementary school affect the neurobiology of children. Specifically, I aim to study how adverse social experiences (1) affect DNA methylation of genes implicated with stress regulation, and (2) affect neurocognitive functions underlying self-regulation, thereby increasing aggression. I will use a multidisciplinary approach to comprehensively study these hypotheses by using the strengths of twin-, observational and experimental studies. I will first study the impact of bully-victimization on children’s methylation of DNA and neurocognitive function development in monozygotic twins differing in bully-victimization, to test whether bully-victimization affects the neurobiology above and beyond possible genetic effects.I will then focuses on cross-time influences of multiple social experiences on DNA methylation and neurocognitive functions. Adverse versus protective effects of peer- and teacher-relations on DNA methylation and neurocognitive functions will be studied to explore possible cascading, accentuation, and buffering effects. Further, sex differences will be addressed.In the final set of (lab-experimental) studies I aim to unravel how DNA methylation of genes implicated with stress system responses, and altered neurocognit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Collective quantum operations for information technologies' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The purpose of this project is to study quantum systems which allow only a partial control by a constrained set of quantum operations. Typical examples are many particle quantum systems like cold atoms in optical lattices or other multi-atom ensembles, which can be manipulated collectively but not individually (e.g. because the spatial resolution of the used devices is not good enough to address single particles). Such restrictions are currently one of the biggest obstacles against working quantum computers. Instead of improving the corresponding experimental methods (i.e. searching for better implementations) this project aims at a systematic study of the tasks which can be performed with currently available techniques. To this end we want to develop theoretical models which can on the one hand reflect the limitations of current experimental setups, but are on the other hand powerful enough to allow non-trivial practical applications. This point of view is new and complementary to most other research in quantum information science, where complete control over a small number of particles is assumed.  Based on these models we plan in a second step to produce strategies for the generation ofdevices which are -- at least for a very special task -- more powerful than classical computers, and at the same time easily implementable. Possible applications of this procedure are simulations of other quantum systems, like models for ferromagnetic materials with long range quantum correlations or lattice approximations of quantum field theories, which can not be treated efficiently on classical computers (i.e. the computation time grows exponentially with the system size). The advantage of our approach over other research which directly  tries to implement universal quantum compute
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'HiPERCAM: A high-speed camera for the study of rapid variability in the Universe' (HIPERCAM).

assistant: **Innovation**

When stars die, they form white dwarfs, neutron stars or black holes. These are key objects in astrophysics as their extreme gravities, densities and pressures allow us to test our theories of fundamental physics at the limits of their predictive powers. One of the best ways of studying white dwarfs, neutron stars and black holes is via their variations in brightness. Unfortunately, due to the small physical sizes of these objects, they are extremely faint and their variability occurs on timescales of milliseconds to seconds, too fast to be recorded by the current generation of astronomical instruments on the world's largest telescopes.What is required is a new type of astronomical instrument with the capability to take high-speed exposures with no noise from either the detector or the atmosphere. Such an instrument would enable us to answer some of the most important questions in astrophysics, such as: What are the progenitors of type Ia supernovae? What is the equation of state of the degenerate matter found in white dwarfs and neutron stars? What is the nature of the flow of matter close to the event horizon of black holes? What gravitational wave signals are likely to be detected by the next generation of space and ground-based detectors?My aim is to answer the above questions by building and exploiting a new astronomical instrument: HiPERCAM. HiPERCAM will be by far the best high-speed camera in the world, giving an order of magnitude improvement in performance over what has come before. It will be mounted on the world's best telescopes, including the 8.2-m VLT in Chile and the 10.4-m GTC on La Palma. This revolutionary new camera will incorporate a novel scintillation-correction mechanism and the latest in low-noise, high-speed detector technology. Although challe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tele-Medicine Platform to support Home Rehabilitation based on Internet Technologies' to be submitted under Fifth Framework.

assistant: **Abstract**

In the envisaged scenario, where a rehabilitation treatment is prescribed, the physician, in co-operation with the physiotherapist, identifies a personalised rehabilitation program for the patient, taking into account the patient status and needs. At the centre, the rehabilitation protocol is accurately defined, based on actual patient status; using the Rehabilitation process management tool the rehabilitation period, the frequency of visits, possible additional examinations, is accurately planned, based on patients personal needs.Based on patients condition, the period in which the treatment needs to be performed at the rehabilitation centre can be reduced to the minimum; the remaining treatment is performed at patients home, using Rehabilitation machines that are connected to the Internet via a modem. Through the Supervision system and the Internet connection, the Rehabilitation machines receive the session parameters and transmit the patients data. The specialist can then monitor the patients performance in real time of the ongoing session, and can graphically display the patients parameters to identify any possible problem. All data are also stored in a Central repository to allow an accurate review of the results and an adjustment of the rehabilitation protocol if needed. In the subsequent sessions, the Supervision system will download the updated parameters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A Mnemonic system based on stimulation-free Neuroimaging' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This project’s aim is the commercialization of a neurotechnology device, MNeuronic, that helps its users to improve their memory retention. MNeuronic can be used in cognitive rehabilitation on patients with mild to moderate decline in memory function as well as by healthy users, as a cognitive training method at home. The system will be mounted on wearable, relatively affordable hardware. Its core technology is grounded on principles and ideas developed in my current ERC-StG project on attention and perception. In particular, MNeuronic capitalizes on the natural fluctuations of neural excitability in the human brain using real-time phase prediction. This confers two important commercial strengths. One is efficiency, because MNeuronic anticipates upcoming optimal brain states before they occur, rather than reacting to past states. Second, MNeuronic affords unprecedented levels of temporal precision. Besides its direct application for memory enhancement, the core principles that ground MNeuronic are transferable to further applications in neurotechnology for learning/education, cognitive training, recreation (neurogaming) or, wellness. This opens a second commercialization route that reaches out to other neurotechnology companies, which will also be exploited in this project. The software implementing MNeuronic (real-time analysis filters and prediction algorithms) will be protected under a dual license that will allow us to combine a proprietary license offered to client companies, and open-licenses addressed to non-profit research and education organizations. Because MNeuronic offers non-invasive, stimulation-free solutions, it will appeal as a less aggressive rehabilitation support tool to be marketed in clinical contexts. In addition, with an effort toward affordable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Intake Flow Simulation and Optimisation for Hydropower'.

assistant: **Objectives**

The flow simulation and optimization in terms of the efficient water power utilization is the essential topic of the proposal. The main goals of the submitted project are: - To identify the negative influence of ill-designed intake structures at run-off river power plants on the water turbine efficiency and the rotor vibrations; - To find and prove the methodology of intake structure geometry optimization by means of the numerical flow simulation and the physical modelling, and to reach the best conditions for maximal turbine efficiency and its output. The project combines civil hydraulic engineering with mechanical hydraulic engineering. Turbine producers focus on the design of a runner and adjacent water passage, whereas civil engineers concentrate on a broader area of free surface. The project is going to solve the complex intake flow interdisciplinary concerning the entire intake section configuration. The fellow will thus utilize his recent expertise in both fields and to help bridging the existing gap between both civil and mechanical engineering. Undertaking of the project will also enable the fellow to acquire the better familiarity with CFD simulation methods and their implementation into hydropower and to deepen many other complementary skills. The excellent computation accessories of the host organization will be used for flow simulations. The computed results will be verified on a physical test model in the Hydraulic laboratory at the host institution too. Modern disturbance-free laser anemometry will be applied for measurements at physical model. Regarding the support of power renewable resources, the resolved problems are very current nowadays. There are lots of refurbishments of outdated low head run-off river power plants in order to increase higher effi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Modelling of complex Earth systems' (MODCES).

assistant: **Concept**

I propose to re-establish my research group specializing in modelling complex Earth systems by sophisticated numerical methods, analog experimentation and field studies, following my move from the Australian National University to the University of Rennes 1 (Geosciences-Rennes.). The main area of investigation of the group will be the study of the interactions between the Earth's crust, the overlying hydrosphere and the underlying mantle during major orogenic events, past and present. Coupling along the Earth's surface is through erosion, mass transport and sedimentation by a range of processes including fluvial, hill-slope and glacial processes. Deformation of the crust is caused by the large-scale movement of the tectonic plates, itself driven by buoyancy forces originating in the convecting mantle. To study this complex system, I propose a unique and ambitious multi-disciplinary approach combining the use of numerical methods, analog experimentation and field-based data collection. The innovation of the proposed research lies not only in the questions that it addresses about the behaviour of the Earth's system on geological time scales, but also on the sophisticated, state-of-the-art numerical methods that have been developed and will be used. In particular, a unique three-dimensional model of lithospheric deformation will be coupled to a plan-form landscape evolution model. Funding is requested for equipment (the construction of a dedicated computing facility), personal (post-doctoral fellow and PhD student) and travel. The proposed research will contribute to enhance EU scientific excellence by facilitating the return of a European researcher after almost twenty years of research activity overseas (in Canada and Australia) and will promote his re-integration within
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Understanding the Stability and Plasticity of Emotional Memory' (ErasingFear).

assistant: **Concept**

The breakthrough discovery in animal research that fear memories may change upon retrieval – referred to as memory reconsolidation – has drastically changed the view on the malleability of emotional memory. Inspired by these insights, we have developed a novel approach to pharmacologically erase the affective component from fear memories in humans. Although these findings suggest a paradigm shift in clinical practice, there are many fundamental questions to be resolved.The objective of this proposal is to gain an in-depth, comprehensive understanding of the dynamic balance between the stability and malleability of emotional memory, and consequently develop a revolutionary theory-driven treatment for emotional memory disorders.This program presents a novel mechanistic framework on memory reconsolidation challenging in several ways the dominant model of emotional memory modification. First, while during traditional interventions cognitive changes are required for a reduction in fear, in our procedure cognitive changes preclude the neutralization of fear memory. On the other hand, post-retrieval changes in the cognitive (WP1) and neural  (WP2) expression of fear memory may serve as read-outs to demarcate the underlying processes necessary for memory reconsolidation. Second, in contrast to the immediate, but gradual decline of fear during traditional interventions, with memory reconsolidation the fear reduction is delayed, yet abrupt, and sleep may be essential (WP3). A thorough understanding of these processes is essential for developing a reconsolidation intervention in clinical practice (WP4). Finally, the program aims to understand the paradoxical dissociation, yet interdependence, between the cognitive and emotional expressions of fear memory (WP5). This proposal is un