RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Numerical CRACK simulation and Identification Techniques' in the context of a Horizon 2020 call.

assistant: **Objectives**

Europe’s built cultural heritage is very diverse, ranging from large and impressive Roman amphitheaters to small and modest dwellings of European cities’ historic quarters. Despite the immense differences in dimensions, architecture and use, these structures share the construction technique: brick or stone masonry. Built cultural heritage is a key factor for Europe’s social cohesion, economic growth and sustainable development. However, heritage structures in a large part of Europe are under the threat of earthquakes. While we can do nothing to prevent earthquakes, we can prepare predictive tools for assessing the seismic safety of masonry structures. This proposal aims to develop numerical CRACK simulation and Identification Techniques (CRACK-IT) for stone masonry structures that can be used in professional practice. To achieve this, we will first develop a crack detection tool that will allow the automatic and objective crack documentation of damaged masonry structures, by combining information from experiments with image processing and machine learning aproaches. This tool aims to be applicable in post-earthquake surveys for automated crack detection in masonry structures. Second, we will develop and validate a structural analysis tool that permits the efficient and accurate simulation of stone masonry structures and the robust estimation of their seismic response. For this, we will focus on the simulation of irregular stone masonry, because despite being a common used typology in historic structures, there is still no structural analysis approach tailored to it. The core for the development of these two numerical tools will be the execution of an experimental campaign including the shear-compression tests of irregular stone masonry walls. This campaign, apart from a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Structural basis of Cullin-RING ligase regulation by the COP9 signalosome' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The components of the Cullin-RING Ligase (CRLs) E3 ubiquitin ligase family play key roles in a wide range of cellular processes including stress response, signal transduction, apoptosis and cell cycle progression, and accordingly, defects in their function and/or regulation are prominent in many pathologies including cancer. The modular CRL architecture is centred upon one of seven different cullin scaffold proteins which associate on one side with a RING protein that acts as receptor for an E2 ligase and, on the opposite side, with a substrate receptor (SR) that confers specificity to the complex. The multiplicity of SRs allows the recognition of many different substrates by the same CRL catalytic core. CRL-mediated ubiquitination modulates the substrate´s biological activity and in many cases targets them for proteasomal degradation. The COP9 signalosome (CSN) complex plays a fundamental role in CRL regulation both by forming stable inhibitory complexes with the CRLs where the E2 ligase and substrate binding sites are occluded, and by enzymatically removing Nedd8 (a homologue of ubiquitin) from the cullin scaffold subunit, in a process termed deneddylation, that leads to inactivation of CRLs. CRL regulation by CSN is still an incompletely understood topic mostly because of the lack of high resolution CSN/CRL structures due to the challenge that the crystallization of multi-protein assemblies of such complexity represents. Fortunately, recent technological developments in another structural technique, cryoelectron microscopy, now allow structure determination of relatively small protein complexes (< 500kDa) to near-atomic resolution. Hence, we propose to use this powerful technique to reveal very high-resolution structures of several different CSN/CRL holocomplexes and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modulation of cortical activity by median raphe neuronal assemblies with identified behavioural effects' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Cortical operations are built up from states associated with distinct behaviour-dependent network activity patterns that subserve information aquisition, encoding, memory consolidation and retrieval. Thus, they can be considered as manifestations of different processing modes. Groups of modulatory, largely monoaminergic neurons located in subcortical nuclei innervating all forebrain areas are indispensable for the generation, stabilization and termination of cortical activity states. In recent years the concept of subcortical modulation has been expanded by the discovery of a fast type of modulatory action driving the rapid readjustment of cortical activity and associated behaviours. Thus, cortical networks are under the influence of a tonic, slow, as well as a phasic, rapid component of subcortical modulation that are acting in parallel. Results from our laboratory revealed that the median raphe (MR) nucleus, one of the main sources of serotonergic innervation of the limbic system , besides the non-synaptic diffuse action, also exerts a fast type of modulation via the selective innervation of cortical GABAergic interneurons. This selective effect on local inhibition may be ideal for the synchronous resetting of the target principal cell circuits, or for the continuous tuning of their activity. These discoveries, together with the methodological advances of recent years, enable us to map the neuronal network mechanisms behind transitions of brain states, as well as associated behaviours, induced by subcortical inputs. We will focus on the MR – limbic connection with the aim to unravel the physiological, pharmacological and anatomical features of MR neuronal assemblies, both the slow- and fast-acting, as well as the serotonergic and glutamatergic components (together wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tracing the Epipalaeolithic origins of plant management in southwest Asia' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The transition from foraging to farming represents one of the most transcendental shifts in the history of humanity. Decades of research in southwest Asia have shown that this process culminated with the development of Neolithic agricultural systems c. 10 ka cal. BP. Yet, how it started, that is, how hunter-gatherers became, for the first time, engaged with the management of plants, continues to be largely undetermined. Palaeorigins aims to fill this major gap of knowledge. Benefiting from the exceptional Epipalaeolithic archaeobotanical materials that are now available (c. 23-11 ka cal. BP), it will ask: To what extent were Epipalaeolithic hunter-gatherers managing the land and the plant resources around them? Did climatic factors trigger plant resource intensification, or were cultural dynamics, like the need for specific foodstuffs, that first motivated plant-food production? To achieve such an ambitious aim PalaeOrigins will pioneer a holistic and high-resolution approach to study the plant-based subsistence. It will use a unique combination of traditional and most novel archaeobotanical materials, state-of-the-art stable isotope analyses, computational science, and theoretical models to: 1) Reconstruct the distribution and availability of plant resources during the environmental shifts of the late Pleistocene and the early Holocene; 2) Determine how plant procurement strategies, land uses and management activities articulated during the Epipalaeolithic period; and 3) Define hunter-gatherers' food culture, assessing their plant-food selection, processing and consumption practices. Taken together, PalaeOrigins will move beyond traditional Neolithic-centred paradigms to explain the origins of plant-food production. It will open up new research horizons, merging scienc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Forest conservation in a changing world: using the past to manage the future' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Current ecological understanding has recognised that most ecosystems are dynamic; all are subject to ongoing processes of environmental disturbances, and many landscapes have been shaped by humans for millennia. This is particularly true for European forests, many of which were first cleared by humans around 6000 yr ago. With predictions suggesting that climatic variability will increase and human impact in many regions becoming more intense, it is essential that we have the capability to understand and man age the response of the vegetation. This is especially the case in the natural temperate woodlands of Europe, many of which maintain a level of biodiversity not seen elsewhere. However, almost without exception, the management of these natural forests is focussed on practices that see these forest systems as stable and any change, be it from human activity or climate, as detrimental; the ultimate goal in most of these conservation practices is to maintain the status quo or restore the forests to some former's natural benchmark. But what are these `natural benchmarks? This project proposes to reconstruct long-term vegetation histories of some of largest tracts of undisturbed natural temperate forests in Europe, in Romania.The research will concentrate on the long-term vegetation dynamics of the Apuseni Natural Park, a region of high natural biodiversity. The project aims to inform on the natural variability of this forest over time in response to climate change, other disturbances such as fire, and human impact. Techniques will include analysis of fossil pollen, plant macrofossils, charcoal, stable isotopes 13C, 15N, mineral magnetic records in combination with Pb210 and 14C dating. Results will be directly applied to management practices and planning of the A puseni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'African Abolitionism: The Rise and Transformations of Anti-Slavery in Africa' (AFRAB).

assistant: **Concept**

The historiography of Euro-American abolitionism is so vast that it has a history of its own (Brown 2006). By contrast, research on African abolitionism is a narrow field focused primarily on European anti-slavery activities. It presupposes that when Europe abolished slavery in Africa, Africans became abolitionists. This conclusion is unfounded. Many general questions have never been asked: When and where did African abolitionist movements develop? Who are the main ideologues of African abolitionism? How did abolitionism spread, among which groups? What forms of political struggle did African anti-slavery give rise to? While individual African abolitionists and regional movements have attracted limited attention, there is no major review of the phenomenon on a continental scale. AFRAB fills this gap. It contributes to African and global history and slavery studies by analyzing and comparing African abolitionist ideas and anti-slavery movements, the long-term consequences of European abolitionism, and the resilience of pro-slavery discourses.


**Keywords:** Slavery,  abolition,  abolitionism,  Africa,  colonialism,  missions,  NGOs,  activism,  social movements,  resistance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Breakthrough solutions for adaptable envelopes for building refurbishment' (BRESAER) under Horizon 2020.

assistant: **Objectives**

The overall objective of BRESAER project is to design, develop and demonstrate an innovative, cost-effective, adaptable and industrialized envelope system for buildings refurbishment including combined active and passive pre-fabricated solutions integrated in a versatile lightweight structural mesh:‒ Dynamic window with automatic and controlled air-tightness and insulated solar blinds complementing energy saving and visual comfort strategies, such as light redirection and response to solar radiation‒ Multifunctional and multilayer insulation panels made of Ultra High Performance Fibre Reinforced Concrete to be used as rigid shells integrating an insulation material‒ Combined solar thermal air and PV envelope component for indoor space heating and ventilation, thermal insulation and electricity generation‒ Multifunctional lightweight ventilated façade module‒ BIPV and Combined thermo-reflexive (improving fire resistance) and self-cleaning coating (through photo-catalytic nanoparticles)The building will be governed by an innovative BEMS covering a specific control system for governing the envelope, the energy use of the building and the strategies for the electrical energy storage.A real demonstration will be performed in an education building in Turkey. Four additional virtual demonstrations will be done in using real building in other European countries covering complementary climatic zones, constructed before the EPBD requirements were enacted.Expected impact:‒ Energy demand reduction for space heating and cooling 30,7% due to envelope refurbishment‒ Contribution solar thermal for space conditioning of 37,3%‒ Contribution of RES for electricity of 12,8%‒ The combination gives a total primary energy consumption reduction of 76,4%‒ Improved indoor environment quality by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel permanent magnets for high temperature applications' (HITEMAG) under Fifth Framework.

assistant: **Objectives**

the aim of this project is the development of new magnetic materials and prototype devices for high temperature applications i.e. up to 450C working temperature. New standards and measurement protocols will also be developed and defined for high temperature permanent magnets. The discovery of high -performance NdFeB magnets in 1983 has led to an extraordinary development of permanent magnet applications. The annual global production of these materials is presently over 10000 tones. The properties of these materials however rapidly degrade as temperature is increased and they cannot be used above 150°C-180°C. From these temperatures and up to 300°C, the Sm(Co,Cu, Fe, Zr) magnets are preferred to the NdFeb. Above this temperature, no material is available although important potential applications exist in the fields of aeronautics, the space (satellite) industry, electronics, and the automotive (petrol and electric) industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Biocontamination Integrated cOntrol of Wet sYstems for Space Exploration' under Horizon 2020.

assistant: **Concept**

Microbiological contamination can be attenuated, never eliminated. Space exploration requires development of reliable rapid significant and safe methods for preventing, monitoring and control the biocontamination within manned closed environments. These methods have to be automated, simple and conceived to decrease the (re-)supply mass from ground.Both space and terrestrial monitoring and prevention/mitigation methods are currently working separately instead of working in synergy. The proposed BIOWYSE project foresees development and demonstration of an integrated system suitable for future accommodation aboard the International Space Station (ISS) and from a long-term viewpoint, within Moon and Mars habitats. The BIOWYSE consortium will design, build and test single prevention, monitoring and mitigation modules. Thus, they will be integrated in a single system inside a compact breadboard and tested. Critical aspects or gravity-dependent technologies of the breadboard will be designed with the perspective of a future accommodation within a rack of the ISS (e.g.: in EDR-2 of Columbus), as a precursor of elements for long-duration space missions and future planetary outposts (e.g. Mars). In order to validate key technologies for the biocontamination control integrated system in real conditions and with representative features, the BIOWYSE project is based on the following major objectives:1. Exploitation of ISS data from recent project related to the system functionalities2. Designing single modules taking into account the intent of a demonstration aboard an International Standard Payload Rack 3. Building a system in order to test integrated key technologies 4. Developing and demonstrating operational techniques and processes for preventing, monitoring and mitigating the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Story Maker' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Wonder Media Productions (WMP) is a SME active in the development of 3D animation software and the production of related animated content. With its disruptive animation software technology called animation now, WMP has the ambition to change the way animation is being created, produced, expressed and used. Key differentiators compared to state-of-the-art 3D animation software suits are its real-time capabilities, its ease of use, and its cost efficiency. This makes it possible for untrained people to create their own stories using 3D animation.One highly interesting application for this animation technology is its use as a tool for education. Within the project Story Maker, WMP has the ambition to develop its tool into a project-based digital learning solution and to introduce it into the EU educational market. Within the project, WMP will achieve different developments envisaged for a commercially viable digital learning solution based on animation now. WMP will provide a proof of concept of the Story Maker educational tool and will extend its available libraries of animated content. Furthermore, WMP will study the economic feasibility of the project by a detailed market and competition analysis, identify key stakeholders and strategic potential partners, will perform an internal cost analysis and develop the business model, beside legal and regulatory framework studies.Story Maker project will address identified needs of schools, teachers and students and will impact about 10 million students in primary and secondary education in about 100.000 schools in Europe, with more than 450.000 teachers involved. The project will change the way teachers motivate children to learn with modern tools and will help children to become more creative and express themselves in a purpos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'LUCERO - Smart Optofluidic Micromanipulation of Biological Samples' (LUCERO) targeting Horizon 2020.

assistant: **Abstract**

The goal of Lucero is to create autonomous micromanipulation solutions for biological applications integrating optical manipulation, microfluidics, and machine intelligence. Single-cell analysis is critical in many biomedical applications, such as clinical trials, in-vitro fertilization, forensic analysis, and single-cell omics. In fact, it is an ideal moment to enter the single-cell analysis market, because this market is valued at $1.4 billion globally and expected to keep on growing with a compound annual rate higher than 17%. While some techniques are already commercially available, single-cell approaches still have several limitations. Mechanical tools (e.g., motorised micropipettes and microneedles, centrifugation) are invasive and prone to damage the cells. Labeled-sorting methods (e.g., flow-cytometry) can affect cell viability for subsequent protocols. Non-invasive sorting procedures based on microfluidics require high amounts of cells and numerous repetitions to obtain a significant fraction of target cells. Furthermore, in all cases these methods require expert handling and are labor intensive. With Lucero, we propose a solution that overcomes these problems based on a smart optofluidic platform: contactless thanks to the use of optical tweezers, capable of controlling the local cellular environment thanks to the use of microfluidics, and capable of autonomous and accurate operation thanks to machine intelligence. Lucero will be compatible with standard microscopes already available in biomedical laboratories, permit to completely automatize single-cell protocols, and therefore drastically lower the cost of biomedical research. Lucero already counts with an outstanding core team of scientists and experienced business people, and it will provide ~20 jobs to un