RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'FS MARINE+: Hydrogen syngas injection unit for ships to save fuel and cut emissions' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

FS MARINE+ is the world's first hydrogen-powered engine assistant unit for ships. The patented hydrogen generator produces a proprietary synthetic gas that is injected into a ship's engines to significantly improve combustion efficiency.FS MARINE+ has been proven to reduce net fuel consumption by at least 10%, cut carbon dioxide (CO2) emissions by at least 10%, cut nitrogen oxide (NOX) emissions by at least 50%, and save at least 33% on engine maintenance costs.The customizable unit can be installed on any vessel, and the cost amortized within three years. This makes FS MARINE+ the most viable technology for overcoming the shipping sector’s environmental and economic challenges. Regulations require ships to reduce CO2 by 10% every five years. Struggling operators must cut fuel costs, which make up 50-60% of expenses.For an average ship, FS MARINE+ will save €2.9M in fuel and maintenance costs and prevent 19,200 tonnes of CO2 over 10 years. The company offers ROI-based pricing and build-lease-transfer options to make it accessible even for cash-restricted shipping companies.As a pioneering technology innovation, FS MARINE+ has no direct competition and is protected by two patents. Indirect competition comes from energy efficiency and pollution abatement methods that have inferior outcomes.There are 50,442 seagoing vessels worldwide, and 16,500 inland vessels registered in Europe. 50% are viable for FS MARINE+. This creates a total reachable market size of €28.1 billion. The company aims to sell 379 units and earn €181M in revenue by 2021. Demand and willingness to pay have been demonstrated through pre-commercial test and sales agreements from 11 shipping companies with a combined fleet of 159 vessels.FS MARINE+ is the innovation of FUELSAVE GmbH, a German engineering co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Does vegetation derived organic nitrogen fuel algal blooms in coastal waters of the Baltic Sea?'.

assistant: **Concept**

Shallow coastal waters in the Baltic Sea, rich in organic matter, are threatened by toxic dinoflagellates blooms, which have deleterious effect on human health and aquatic life. The toxic Alexandrium ostenfeldii blooms in coastal waters where vegetation start to decompose in late summer and release dissolved organic nitrogen (DON). Dinoflagellates are potentially mixotrophic; they are photosynthetic and can use DON. However, the mixotrophic activity for Alexandrium in the Baltic Sea is unknown. The issue will be addressed using stable isotope 15N tracer experiments with enriched substrates from decaying vegetation and visualization of N incorporation pathway (direct uptake or via bacteria) in individual cells using NanoSIMS to determine the mixotrophic capacity of Alexandrium from different geographical sites in the Baltic Sea that differ in vegetation cover and type. A difference in adaptation to N sources may further support the genetic differentiation shown between Alexandrium populations in different areas of the Baltic Sea. The project will provide new understanding to nutritional physiological ecology of toxic dinoflagellates. Our aim is to understand if DON from decaying vegetation can be a source of N for toxic Alexandrium blooms in the Baltic Sea. By matching vegetation and habitat variables with Alexandrium bloom occurrence and mixotrophic activity we will develop a tool to identify potential bloom sites of Alexandrium in shallow coastal waters and to make recommendations for local management. If the application is accepted as IF the training in population genetics and spatial modelling using A. ostenfeldii as a model species, will be a key step for the development of the applicant in light of the research objectives towards modelling how metabolic activity di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'AROMATIC FOLDAMERS AS DRUG DELIVERY CARRIERS'.

assistant: **Objectives**

The Huc group is a world leading research team in the fields of Biomimetic and Bioorganic Chemistry. One of group’s main contributions is focused on the synthesis, structural elucidation and biological application of aromatic oligoamides. These compounds adopt exceptionally stable folded conformations, helices, stabilised by intramolecular hydrogen bonds and - interactions. The high structural predictability, tunability, ease of synthesis and resistance to hydrolysis of such foldamers has led to an increasing attention towards those oligoamides. Very recently, Huc and co-workers have proven that despite the high hydrophobicity of those aromatic foldamers, they can be made highly hydrosoluble by inserting cationic side chains, providing important possibilities for their biological application as cell penetrating agents. This project focuses on the investigation of structural characteristics and the ability of aromatic oligoamides to cross the cellular membrane and deliver different cargoes efficiently. The qualitative and quantitative determination of uptake of the helices, intracellular trafficking and translocation of cargo will very importantly allow us to gain an insight into the kinetics and mechanism underlying the cellular translocation, areas that are currently being subject to a lot of controversy. The project is concerned with an emerging area of interdisciplinary chemical research in which the development of drug delivery technologies based on the new understanding of cross-membrane transport is expected to have a very strong impact on health and the design of novel therapeutic and diagnostic agents.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The role of an expanded family of exported effector kinases in environmental sensing and regulation of virulence in human malaria.' in the context of a Horizon Europe call.

assistant: **Objectives**

The most severe form of malaria in humans is caused by Plasmodium falciparum. Cytoadhesion of infected red blood cells (iRBCs) to host endothelium and iRBC rigidification are the major contributors to pathology. Cytoadhesion is mediated by transport of a protein called PfEMP1 onto the surface of the iRBC. It prevents clearance of iRBCs in the spleen and promotes parasite survival, but can cause the obstruction of blood vessels leading to pathology. Thus, the parasite has to strike a fine balance between preventing its own clearance through sufficiently strong cytoadhesion and control of rigidity, and killing the host. The paradigm in the field is that the strength of cytoadhesion is dominated by expression of PfEMP1 variants with different affinities for host cell receptors. We now have strong evidence that the parasite can rapidly regulate its cytoadhesive properties using a family of atypical kinases (the FIKK kinases) it exports into the host cell. This gives the parasite a yet unrecognized ability to respond to conditions encountered in the host, such as fever or hypoxia in areas of high parasite sequestration, and influence disease outcome. This is important: Of the 6 human infecting Plasmodium species only P. falciparum exports FIKK kinases into the host cell. As this species is responsible for ~95% of all fatal human malaria cases, it is paramount to understand FIKK- function in pathogenesis. We will use cutting edge approaches to: (1) identify the function of FIKK kinases in controlling cytoadhesion and rigidity in conditions frequently encountered in the human host and determine RBC remodelling in samples from patients. (2) Identify the molecular underpinnings of FIKK function in controlling cytoadhesion and (3) perform a thorough biochemical characterisation o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Stable Halide Perovskite Nanocrystals for Efficient Optoelectronic Devices' (StabPerov) targeting Horizon 2020.

assistant: **Abstract**

Perovskites have shown impressively outstanding performance in solar cells and light emitting diodes (LEDs) but are still limited by the non-negligible stability issues. With high efficiency achieved, now it is time to fill the research gap for pursuing stable perovskites. My priority goal for the StabPerov project is to obtain highly stable perovskite nanocrystals by using amphiphilic molecules such as liposomes. Upon successful realized, more stable optoelectrical devices can be explored targeting one of the most serious concern for commercialization of perovskite based applications. At the beginning of my project, I will optimize the synthesis of perovskites nanocrystals. For coating perovskites, amphiphilic molecules are used as coating materials. The amphiphilic molecules may also function as ligands. Different types of amphiphilic molecules will be introduced. Detailed and comprehensive characterizations of (HR)TEM, XRD and optical spectroscopy of materials will be carried out before and after degradation. The stability improvement of perovskite nanocrystals is now urgent, whilst getting the insight of how perovskites are decomposed is also necessary with regard to optimize synthesis and to evaluate protected nanocrystals. At the next stage, the as-prepared high quality stable perovskite nanocrystals will serve as emitters and catalysts for the demonstration of applications. My results are of great feasibility and practical significance, which pave the way towards the applications of stable high performance perovskite based devices. Combining my background with the training of optical spectroscopy offered by the host as well as being an independent investigator of this project, the Marie Curie fellowship will not only provide an excellent chance for me to become a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Large-scale computation without synchronisation' to be submitted under Seventh Framework.

assistant: **Abstract**

The goal of SyncFree is to enable large-scale distributed applications without global synchronisation, by exploiting the recent concept of Conflict-free Replicated Data Types (CRDTs). CRDTs allow unsynchronised concurrent updates, yet ensure data consistency. This revolutionary approach maximises responsiveness and availability; it enables locating data near its users, in decentralised clouds.<br/>Global-scale applications, such as virtual wallets, advertising platforms, social networks, online games, or collaboration networks, require consistency across distributed data items. As networked users, objects, devices, and sensors proliferate, the consistency issue is increasingly acute for the software industry. Current alternatives are both unsatisfactory: either to rely on synchronisation to ensure strong consistency, or to forfeit synchronisation and consistency altogether with ad-hoc eventual consistency. The former approach does not scale beyond a single data centre and is expensive. The latter is extremely difficult to understand, and remains error-prone, even for highly-skilled programmers.<br/>SyncFree avoids both global synchronisation and the complexities of ad-hoc eventual consistency by leveraging the formal properties of CRDTs. CRDTs are designed so that unsynchronised concurrent updates do not conflict and have well-defined semantics. By combining CRDT objects from a standard library of proven datatypes (counters, sets, graphs, sequences, etc.), large-scale distributed programming is simpler and less error-prone. CRDTs are a practical and cost-effective approach.<br/>The SyncFree project will develop both theoretical and practical understanding of large-scale synchronisation-free programming based on CRDTs. Project results will be new industrial applications,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Structural and mechanistic insights into RING E3-mediated ubiquitination' under Horizon 2020.

assistant: **Concept**

Ubiquitin (Ub) conjugation regulates a myriad of cellular processes in the eukaryotic cell. Ub-ligases (E3) play a pivotal role in deciding the substrate’s fate and function by catalyzing the transfer of Ub from Ub-conjugating enzyme (E2) to a substrate protein lysine sidechain. Successive rounds of E3-catalyzed substrate ubiquitination lead to the formation of poly-Ub chains or multi-monoubiquitination, which direct the substrate to different biological fates such as degradation by the 26S proteasome. RING E3s comprise the largest family of E3s with approximately 600 members in humans. Over the last fifteen years, structural biology and biochemical studies have paved the way for understanding how RING E3s interact with E2s and substrates, and how they are regulated. Recently my group has trapped the crystal structure of a RING E3 bound to an E2 covalently-linked to Ub (E2~Ub), thus providing a molecular snapshot of how RING E3 optimizes E2~Ub for catalysis. Despite these advances, the mechanisms of RING E3-catalyzed ubiquitination are not completely understood. Here, we propose to investigate three key aspects of RING E3 functions. First, we will determine structures of several RING E3s bound to E2~Ub to dissect the molecular basis for RING E3-E2~Ub selectivity. Second, our recent structure of a RING E3, Cbl-b, bound to E2~Ub and a substrate peptide provides a starting point for structural determination of a more challenging RING E3-E2~Ub-intact substrate complex to elucidate the mechanisms of substrate ubiquitination. Third, we have developed an ubiquitinated Cbl-substrate mimetic to study the mechanisms of RING E3-catalyzed poly-ubiquitination using structural and biochemical approaches. Expected results will greatly expand our knowledge of RING E3-mediated ubiquitin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Enhancing public awareness on the results of Sustainable Energy Systems research actions through television media' (ENERGY-TV) under Sixth Framework.

assistant: **Objectives**

The strategic objective of ENERGY-TV is to contribute to the development of public awareness on European Sustainable Energy Systems research in all European countries through television media.This objective will be reached through the following activities:- Pilot an innovative media-driven TV communication model for the Sustainable Energy Systems Priority projects.- Fill the existing communication gap between the technical content vehiculed by the Sustainable Energy Systems research and the understanding skills of the general public- Identify the key results of the Sustainable Energy Systems Priority, through the permanent consultation of its relevant constituencies (including the Commission Services and an in-depth punctual research towards individual Sustainable Energy Systems projects).- Create a series of 12 high-quality free-of-rights Video News Releases (VNRs) for the general public on the basis of the key results of the research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Modelling wetland hydrology and the impact of human interference on its hydrological processes' (WETLANDMODEL) targeting Sixth Framework.

assistant: **Abstract**

Wetlands have an important ecological and economic function as water resource and regulation areas. However, this function is very fragile for human interference. Land use changes and climate change may have a large impact on the hydrological processes occ urring in wetland soils. This proposal aims at a description of the changes in soil structure and hydraulic properties in wetland soils triggered by human interference. Both an experimental and a modelling approach are foreseen. In a first phase, field exp eriments will be set up for a quantitative description of the hydraulic properties of wetland soils and the impact of human interference. Laboratory experiments are planned to assess the impact of changing environmental conditions such as temperature and m oisture conditions on the soil hydraulic properties. Based on these data, algorithms will be developed that accurately describe the observed processes. Using data from hill slope scale experiments and runoff measurements, these processes are upscaled from pedon scale to a fully functional hydrological model. Modelling hydrological processes in wetland soils is particularly challenging, as many classical soil-water interaction concepts cannot be applied. Swell and shrink properties, preferential flow paths a nd non-Darcian flow occur much more regularly than in mineral soils. As a result, non-rigid soil theories have to be incorporated in the hydrological model. Finally, the developed model will be used to carry out a scenario analysis which assesses the impac t of future changes in climate and land use on the hydrology of wetlands. The results of this analysis are indispensable for future sustainable wetlands management. The study also has a strong interdisciplinary aspect, combining soil physics with advanced com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Probabilistic neuromorphic architecture for real-time Sensor fusion applied to Smart, water quality monitoring systems' in the context of a Horizon 2020 call.

assistant: **Objectives**

“ProbSenS” will develop a novel low-power event-driven probabilistic Very Large-Scale Integration (VLSI) architecture for real-time, adaptive and robust multisensor integration. Multisensor integration exploits the extended coverage of multiple detectors to increase perceptual confidence in Smart Systems, but embedded implementations are yet in their infancy due to the lack of hardware able to infer from the multivariate, nonlinear, time-dependent and noisy signals supplied by modern sensors. By using principles of how biological systems promptly combine multisensory information and generate meaningful features in dynamic and uncontrolled real-world conditions, bioinspired Generative Deep Neural Network (GDNN) models are emerging as a powerful, CMOS-amenable computing paradigm to accelerate sensor fusion and enable quick, reliable self-learning and context-awareness under these constraints.This project aims to develop such technology into a smaller, smarter, calibration-free multisensor solution, tolerant to sensor drifts and suited to process low-latency data from a varied set of solid-state transducers in critical real-world monitoring/diagnosis scenarios where information is acquired on-line and mostly unlabelled, e.g. security, health and environmental care. ”ProbSenS” will broaden state-of-the-art insight in the following multidisciplinary areas: (i) The modelling of GDNNs as probabilistic processors for adaptive event-based sensor fusion in Smart Systems; (ii) the investigation of novel ultra-low-power VLSI circuits to realise their computational units in low-cost CMOS technologies; (iii) the yet unexplored event-driven fusion of electrochemical and optical microsensors using a GDNN; and (iv) the benchmark of this technology in a true EU societal challenge: the re