RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multifunctional surfaces structured with electroactive and magnetic molecules for electronic and spintronic devices' (ELECTROMAGIC) under Seventh Framework.

assistant: **Objectives**

ELECTROMAGIC is embedded in the field of molecular electronics which has gained much attention during the last decade. The current limitations of the silicon based technology for the fabrication of electronic devices able to fulfil the actual demand, i.e., speed, miniaturization, low cost and flexibility among others has drawn the attention of the scientific community. The use of functional molecules appeared as a very attractive alternative. The current goal is to develop new molecular systems and immobilize them on surfaces to obtain real devices based on the molecular intrinsic properties leading to specific functions such as memories, switches, sensors, etc. The main aim in ELECTROMAGIC is to functionalize surfaces structured with self-assembled monolayer (SAMs) with TTFs and PTMs that are multifunctional (electroactive and magnetic) systems. TTF radical cation and PTM radical forms are highly persistent and have a spin moment. Using these molecules it is possible to obtain surfaces with an electroactive function with optical and magnetic properties that can be easily and reversible tuned. The possibility of performing a partial oxidation of the molecules forming the SAM would permit the electronic transport within the layer itself. Thanks to the opposite electroactive properties of TTFs and PTM, the preparation of mixed SAMs would lead to multifunctional 3-state switch devices. This project addresses some of the main barriers in molecular electronics which in many occasions are limiting the possible future integration of the molecules into real devices, such us the stability of the different states of the molecules (stability of the ON and OFF state of the memory device), the easy access to these different states and, finally the long-term stability. A big effort w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The Free French and the British Forces: a case study of transnational military cooperation, 1940-1945'.

assistant: **Objectives**

FFABFORCE has the following research objectives: to assess the British approach to organising effective multinational forces during the Second World War, using the Free French as a case study, and to analyse the responses of the Free French to their host’s efforts to integrate them. My career objectives are to become a European Research Leader in the university sector and to obtain the skills to work in the private sector as an editor in a history publisher.  The research objectives will be achieved by examining the relevant literature and by doing archival research in at least 11 archives in 3 countries. The sources examined will include government documents, personal papers, diaries and memoirs. The career objectives will be achieved by: training through research under the mentorship of Prof Guillaume Piketty, dissemination activities, training courses on Collaborative Projects, Open Access, ERC grant proposals, data management and interview preparation. This will give me the required skills in advanced project management, teamwork, communication and technical know-how. The research will also help me reach a position of professional maturity, as FFABFORCE will result in my second monograph and deepen my expertise in modern history.My innovative project will contribute to one of the key drivers of Horizon 2020: to develop new knowledge and enhance the skills of excellent researchers. Moreover, one of the societal challenges outlined in Horizon 2020, ‘Europe in a changing world’, aims at ‘supporting inclusive, innovative and reflective European societies’. FFABFORCE will contribute to this goal by increasing academic & public understanding of the transnational nature of the Allied war effort during the Second World War and by demonstrating the weakness of the nation-cen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Simple B-Lactams in the Synthesis of furopyridine Antibiotic: Total Synthesis of CJ-15,696 and Analogues' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The emergence of bacterial resistance has significantly underscored the importance of the discovery of novel classes of antibiotics. The common occurrence of multiple-drug resistant microbes, particularly in hospital settings, is cause for serious clinical concerns. Additionally, the existence of large cohorts of immune compromised patients and the need to utilise anti-infective agents prophylactic ally in their lifetime therapy compound the problem. Finally, the potential activities of dysfunctional nations and their disciples of death are chilling additions to the threat to the welfare of mankind. In 2002 Pfizer scientists reported the isolation of CJ-15, 696 and seven related fur pyridine antibiotics from the fermentation broth of the fungus Cladobotrywn varmint CL 12284. CJ-15, 696 showed modest activities against various Gram-positive bacteria including some drug resistant strains such as Staphylococcus aurous 01 A1 105, Staphylococcus progenies 02C1068, Staphylococcus pneumonia 02J1095 and Entercoccus faecal is 03A1069. S: pneumonia is frequently the causative agent for upper respiratory tract infections and is rapidly acquiring multi.- Drug resistance. Research will focus on the development of a new strategy for the total synthesis of CJ-15, 696. This will be amenable for the concise synthesis of fur pyridines as a general class and for the elaboration of analogues of the natural product to probe antibacterial activity. A concise and flexible total synthesis of CJ-15, 696 should make available a family of fur pyridine derivatives of potential value as novel antibiotics. The synthesis involves a new ring expansion process for the conversion of N-arenesulfonyl-ÿ-lactam derivatives, by reaction with emulates derived from y-lactones, into fur pyridine compounds. A li
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Urban Transitions Mission of Mission Innovation (MI UTM)' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The Urban Transitions Mission (UTM) mobilises decision makers across all levels of government to prioritise climate-neutral and net-zero pathways enabled by clean energy and systemic innovation across all sectors and in urban governance.By accelerating capacity-building and closing the gap between research, development and deployment, the Mission empowers cities to adopt innovative solutions and help reach tipping points in the cost and scale of those solutions for urban transitions.Launched at COP26, the UTM is one of the seven missions of Mission Innovation - a global initiative catalysing a decade of action and investment in research, development and demonstration to make clean energy affordable, attractive and accessible for all. The Mission brokers solutions, approaches, and knowledge for net-zero transitions at each step of a city climate action journey. The work proposed aims to: - Consolidate and capitalize on two years of achievements - ensuring that the Mission stays its course and remains both relevant and ambitious against the ever-evolving goals and challenges that sustainable urban development faces.- Expand the UTM cohort by recruiting up to 200 new cities - working towards the Mission's goal to support 300 cities globally to be well on their way to reach net-zero by 2030- Strengthen capacity building, knowledge sharing and technical support for new and existing cohort of cities - helping cities apply the UTM net-zero Transitions Framework to future-proof their current strategies and climate plans, and offering a platform to exchange robust, cross-sectoral and integrated solutions- Accelerate demonstration of innovative solutions in response to the most urgent needs and R&I priorities for cities - in collaboration with research, academia, a Global Allianc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Genomic and epigenomic signatures of climate-mediated selection in cattle' in the context of a Horizon 2020 call.

assistant: **Objectives**

Official assessments of climate change impacts in Europe predict substantial economic losses due to the progressive upward trend in average temperatures over the next century, and the decrease in annual accumulated rainfall. Global warming will lead to a decreased forage production and quality, and an increased disease risk, which will significantly change conditions for livestock production. Therefore, increasing climate resilience and enhancing sustainable production for animals in harsh environments are important goals for the livestock industry. Fortunately, a natural experiment already exists where a rapid adaptation to extreme climatic conditions was imposed on a limited number of livestock, Columbus’ arrival in the Americas, which therefore provides a model system to study adaptive selection. Given the accumulating evidence that epigenetic processes may increase the evolutionary potential of organisms to respond to stress and other challenges, the aim of this project is to compare the genomes and methylomes of two tropical Creole bovine breeds, their main Spanish ancestors, and one taurine breed from Africa, to understand rapid adaptation to extreme climatic conditions and identifying biomarkers of resilience. The anticipated outcomes from this project will help in designing management systems to improve productivity, thermal and stress tolerance, and disease resistance in cattle.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Multiscale dynamics in soft matter and biophysics' (1998-2002).

assistant: **Concept**

The aim of the school is to teach some selected problems in biophysics together with physical concepts which are of central importance in biology. These include, models of cell adhesion and migration, statics and dynamics of soft matter, complex fluids, dynamics of cytoskeletton and patterns and instabilities in chemistry and biochemistry. The objective is to bring together neighbouring communities and address questions on how to describe in an effective manner problems ranging over a wide spectrum of length and time scales, and whether there is relevant physics emerging from biology.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00418-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding the evolutionary mechanisms of invasion success: Selective footprints in the genome of an Euro-invader – the raccoon dog (Nyctereutes procyonoides)' (EUROINVADERS), addressing dissemination and exploitation.

assistant: **Impact**

It is a worldwide, worrisome phenomenon that faunal endemism is threatened by introduced species populating new habitats, a process that is aided by the growing globalization which makes natural dispersal barriers more permeable. One of the most successful invaders of Europe is the raccoon dog (Nyctereutes procyonoides), a mammal that severely affects endemic biodiversity while thriving in new environments. The species’ peculiar evolutionary history was primarily facilitated by its ability to quickly adapt. While previous research has provided some knowledge of the ecological and environmental conditions the species has adapted to, we lack crucial understanding of the genetic mechanisms that render such a dramatic expansion possible.I propose a genetic study utilizing modern, next generation sequencing and DNA capture methods in order to investigate the underlying mechanisms that have facilitated adaptive processes in raccoon dogs. More specifically, by means of sequencing the complete transcriptomes I will determine candidate loci selection has acted upon, investigate population specific patterns of alternative splicing and lastly infer genes that are differentially expressed. In a second phase of the project I will employ targeted DNA capture on a population wide sampling of European raccoon dogs to assess allele frequency spectra of all candidate loci showing signatures of selection. In combination with additional neutral loci and the implementation of spatially explicit modeling I will develop an evolutionary model depicting how adaptive variants are spread and maintained in a changing environment. By synergizing novel molecular technologies with sophisticated modeling approaches the study pioneers the field of wildlife population genomics and will provide new, valu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Distributed Virtual Prototyping' under Fifth Framework.

assistant: **Concept**

This project will develop a multi-sensory, distributed virtual environment for the prototyping of products. The system will explore and support capabilities that are taken for granted with physical prototypes, but missing in current simulations: natural two-handed manipulation, accurate real-time constraint modelling, and the ability to touch and manipulate objects using haptic feedback. A novel combination of local and distributed processing will be used to meet stringent real-time constraints, while permitting geographically distributed users to interact with a shared model. Assessment and demonstration will be by developing four modular applications: assembly, maintenance, electronic handbook and interactive assistance. These applications support the product life cycle by allowing manufacturing and subsequent usability and maintenance issues to be considered. They are targeted at the aerospace and automotive sectors, but will be important in any industries involved in product design, where assembly, maintenance and customer support - that is, life cycle issues - must be considered during design.Objectives:The objective of the project is to generate a virtual environment that integrates multi-sensory interaction (visual, audio and touch senses), real-world simulation utilities, such as collision detection, gravitational force, and flexible elements and a distributed environment that will allow multiple users, in the same or different locations, to work concurrently with the same virtual model. This environment will be used by different teams, such as design, assembly, maintenance and post-sales teams, throughout the life cycle of a product. The final system will be a Distributed Virtual Prototyping Environment, that will allow users in the same or remote locations to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Identification of the ligand of a human public anti-HCMV/cancer γδ T cell receptor' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

gd T cells are the prototype of unconventional T cells and play an important role in the protection against infections and cancer. The group of David Vermijlen has recently discovered a human Vg8Vd1 T cell receptor (TCR) which was highly enriched in every individual (therfore ""public"") infected in utero with human cytomegalovirus (HCMV), and that reacts towards adult cancer cells, suggesting that it can detect signals of ""cellular stress"" induced in both infections and cell transformation. The major aim of this project is the identification of the ligand of this cross-reactive public Vg8Vd1 TCR. Two strategies will be adopted to address this aim. In the first strategy (indirect approach), a list of candidate ligands will be tested  for the capacity to stimulate the TCR via functional assays. This list of genes is provided by gene expression profiling of target cells known to stimulate the public TCR (""stimulator cells"") verus non-stimulators, as well as from data in literature. In the second strategy (direct approach), in order to isolate or ""fish"" the ligand from a strong stimulator cell line we plan to adopt several methods, such as: i) production of blocking antibodies, ii) generation of ""gd bodies"", iii) proximity dependent biotinylation (BioID). The direct binding of promising ligand candidates with the public Vg8Vd1 TCR will be further investigated by surface plasmon resonance. Finally, in order to address the potential of this project for cancer immunotherapy we will evaluate the killing of primary cancer cells expressing the ligand by public Vg8Vd1-transduced PBMCs.The background of the MSCA applicant on HCMV-host interplay will highly complement the expertise of the group of David Vermijlen on gd T cells. As the public Vg8Vd1 TCR is present in every i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Reshaping the nucleome to reveal its gene- and mechano-regulatory function'.

assistant: **Innovation**

The content of the cell nucleus is highly organized at different levels. Chromatin is partitioned into domains that carry different post-translational histone modifications, and it exhibits a multiscale structural organization from small loops to large compartments. Nuclear RNAs and proteins recognize cues on chromatin, forming different types of chromatin-associated complexes and condensates. The nucleus as a whole is the largest and stiffest organelle of the cell and modulates its mechanical properties. Dysregulation of the nucleome at any level goes along with altered gene- and mechano-regulation in diseases such as metastatic cancers. Currently, the functions of the different organizational levels of chromatin, their mutual relationships and the impact on cellular phenotypes are poorly defined.Progress in this field has been hindered by several technical limitations. One is the inability to study chromatin folding in single living cells, which would allow to interrogate its dynamics, to assess its response to perturbations in real-time, and to relate it to the mechanical properties of the same cell. Another limitation is the lack of tools to selectively reengineer different levels of the nuclear organization to test their function.With the RENOME project, I propose to overcome these limitations by developing systems to study chromatin compartments in real-time and to reshape different organizational levels of the nucleome in a tunable manner. These tools will make it for the first time possible to define the functional impact of nuclear organization across scales, from single molecules to mammalian cultured cells and 3D organoids.RENOME links chromatin regulation, phase separation and nuclear mechanobiology, with the goal to connect molecular mechanisms to cellular
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel drug targets specific to persistent (latent) tuberculosis infection : crystallisation, structure determination and functional studies (persistent tb)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

M.tuberculosis remains the leading cause of death worldwide from an infectious agent and is responsible for nearly three million deaths every year. About one-third of the world population is infected with M. tuberculosis, 10 % of which will develop the disease at some point in their lives. Currently available antibiotics are completely ineffective against persistent bacteria The aim of our project is to solve the 3-D structure of several sterilising drug targets, some of which have been identified by us recently. This would lead to the development of totally novel antibiotics, with completely new modes of action, which are active against stationary phase persistent Mycobacterium tuberculosis. These antibiotics will shorten the duration of chemotherapy and/or synergies with existing antibiotics in humans by reducing bacterial subpopulations, which are tolerant to conventional antimicrobials and thus control reactivation of TB.