RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Demonstration; usefullness of human recombinant proteins in specific measurement of autoimmune antibodies for effective diagnosis and treatment of kidney diseases' in the context of a Fourth Framework call.

assistant: **Objectives**

Antibodies against basement membrane's (BM) collagen (type IV) are formed in some severe autoimmune diseases affecting one of the main function of the kidney, the filtration of urine from the blood. This leads to the degradation of BM, and finally to the loss of the kidney. Most of the cases are fatal, if not treated appropriately. The diagnosis has earlier been based on ono-specific, indirect methods or on non-quantitative ELISA methods utlizing antigens isolated from bovine kidney. The prime proposer of this project has produced the antigenic domains of all six alpha chains of type IV collagen as human recombinatn proteins nearest to their native form. The binding of autoanti-bodies has especially been taken into consideration in downstream processing of the proteins, which have then been used to develop assays for detection of antibodies. These assays are supposed to be much more specific compared to assays which use antigens isolated from animal kidney. The aim of the proposed project is to demonstrate the superior usefulness of human recombinatn proteins in clinical diagnosis and follow-up of treatment autoimmune kidney BM diseases. To be able to correlate the specificity and amount of autoantibodies to the degree of the damage of the tissue (and threatening rejection) of the kidney, the assays will be used complementary with the assays developed by the second proposer SME of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Oxidative attack by necrotophic pathogens new approaches for an innovative and non-biocidal control of plant diseases' to be submitted under Fourth Framework.

assistant: **Abstract**

This research collaboration aims at creating the knowledge basis for a significant innovation in protecting plants from fungal diseases. Currently, the control of fungal diseases in all major crops is based on fungicides possessing biocidal activity against the target organism(s). A reduction in the use of such biocidal plant protectants can be achieved by two strategies: I) improvement of plant resistance by plant breeders, or 2) interference with specific fungal pathogenicity factor(s), which are responsible for fungal aggressiveness and infection. The second strategy requires a comprehensive and detailed knowledge of the infection mechanism. We have located severe gaps in the science of plant pathology and plant protection concerning the 'attack weapons' of the very important necrotrophic pathogens. Necrotrophs need to kill the plant tissue before invading and colonising it. The process of killing (necrotisation) is the crucial step that determines the success of infection. For several economically important pathogens such as the grey mould fungus, Botrytis cinerea, the necrotising factors are not known. B. cinerea causes severe losses in a wide range of crops such as rapeseed, sunflower, beans, cabbage, onions, lettuce, strawberries, ornamentals, grapevine and it also represents a post-harvest problem of many fruits. The threat imposed by this fungus requires the intense and constant use of fungicides in many of these crops. This research proposal builds on the recent discovery that oxidative forces are involved when B. cinerea infects the plant. We demonstrated that aggressive infections trigger an early 'oxidative burst' in the infected plant cells which leads to rapid host cell death and thus enables the infection. As opposed to biotrophic pathogens, which are hi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Algebraic topology' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The scientific objectives are mainly provided by research themes of the French GDR/CNRS number 1110 on Algebraic Topology, to which belong the organisers and about 70 French topologists working at Paris 7, Paris 13, Ecole Polytechnique, Nantes, Lille, nice, Strasbourg and elsewhere.Our proposed event will follow immediately the Annual Assembly of the GDR at Nantes University. Research of this group is centred on present problems of modern Algebraic Topology, concerning mostly algebraic theories coming from the solution of the Sullivan conjecture (like Theories of Unstable Modules over the Steenrod algebra), Homotopy Theories with Models (like Rational Homotopy and Operades), MaClane homology, Cyclic homology and also Algebraic K-theory. Presently we also open research to more geometric problems on quantum invariants of low dimensional manifolds and knot theory. Typical examples are the relations of Vassiliev invariants to universal LIE algebras, Hochschild cohomology and rational homotopy, or foliations and algebraic schemes and L2-cohomology and knot concordance.Our proposal aims to intensify research cooperation of the GDR with two groups of European partners:1) About 40 individual cooperate with topologists in SP Am (Barcelone, Malaga, Santiago, Granada), Belgium (Louvain-La-Neuve), Italy (Bologne), Switzerland (Lausanne, Neuchâtel) have reached a high level calling for regular research meetings. 2) Relations between the Mathematics Departments of Nantes and Duesseldorf (Germany), organised within the institutional framework of the German-French University (UFA), have led to close cooperation with Topology Seminars of Nantes/Angers/Vannes and Duesseldorf/Bonn/Wuppertal.We want to associate them closely to our GDR. By organising regular scientific meetings of the resu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Algorithms for Complex Collective Decisions on Structured Domains' (ACCORD) targeting Horizon 2020.

assistant: **Abstract**

Algorithms for Complex Collective Decisions on Structured Domains. The aim of this proposal is to substantially advance the field of Computational Social Choice, by developing new tools and methodologies that can be used for making complex group decisions in rich and structured environments. We consider settings where each member of a decision-making body has preferences over a finite set of alternatives, and the goal is to synthesise a collective preference over these alternatives, which may take the form of a partial order over the set of alternatives with a predefined structure: examples include selecting a fixed-size set of alternatives, a ranking of the alternatives, a winner and up to two runner-ups, etc. We will formulate desiderata that apply to such preference aggregation procedures, design specific procedures that satisfy as many of these desiderata as possible, and develop efficient algorithms for computing them. As the latter step may be infeasible on general preference domains, we will focus on identifying the least restrictive domains that enable efficient computation, and use real-life preference data to verify whether the associated restrictions are likely to be satisfied in realistic preference aggregation scenarios. Also, we will determine whether our preference aggregation procedures are computationally resistant to malicious behavior. To lower the cognitive burden on the decision-makers, we will extend our procedures to accept partial rankings as inputs. Finally, to further contribute towards bridging the gap between theory and practice of collective decision making, we will provide open-source software implementations of our procedures, and reach out to the potential users to obtain feedback on their practical applicability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'POWER2DM - Predictive model-based decision support for diabetes patient empowerment'.

assistant: **Innovation**

The main objective of POWER2DM is to develop and validate a personalized self-management support system (SMSS) for T1 and T2 diabetes patients that combines and integrates (1) a decision support system (DSS) based on leading European predictive personalized models for diabetes interlinked with predictive computer models, (2) automated e-coaching functionalities based on Behavioural Change Theories, and (3) real-time Personal Data processing and interpretation.The DSS will be based on the complementary combination of proven predictive models for short term plasma glucose prediction, medium term diabetes progression, and long term risk scoring for diabetes complications. These models will be integrated in adaptive personalized behavior change interventions to increase adherence of the patients to their care  program and improve their interaction with health professionals. A cloud-based Data Integration Service, collecting and processing data from personal devices and EHR/PHR in real-time feeds the DSS.The results of the SMSS with respect to clinical parameters, awareness, acceptance and empowerment of the patient to participate in the care process will be evaluated in three studies in NL, DE and ES.The deliverables of the project will  increase self-management capabilities and participation of the patient in the care process, resulting in better self-control and management of the disease. This will lead to better glucose management, thereby preventing severe episodes and long-term complications. POWER2DM will reinforce the prevention sector in healthcare by raising the acceptance of SMSS based on DSS that use predictive models fed by data from personal devices. POWER2DM will challenge individuals towards more frequent and long-term use of personal devices for self-monitor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Actions for the environmental rehabilitation of the Aral sea' to be submitted under Fourth Framework.

assistant: **Abstract**

Foreseen ResultsThe program is designed to bring engineers and scientists together in a structured format in order to exchange results and views on the measures which need to be taken to remedy the current state of affairs in the Aral basin, and to clearly identify all the existing data which can be used to form a sound basis for achieving sustainable management of the water resources of the basin.The general objects of the programme are :a) to bring together scientists and engineers at a technical level, i n order to identify how the constraints that have arisen in finding solutions to the water resourses problems of the Aral basin can be overcomeb) to produce costed collaboratirve proposals for the development of tools which will allow rational planning and management of the water resources of the Aral basin.The specific objectives of the programme are to :(i) produce a combined catalogue of the data and information available in the riparian states and Russia. The catalogue will include information on exactly what information is available, its quality, who holds it, and how it might be obtained(ii) work towards developing an agreed system which will overcome the constraints on the availability of data, including costs and marketing(iii) create a network of researchers capable of developing and working on water management decision support tools(iv) reach agreement between engineers and researchers of the riparian states on the methodologies to be used and identifying optimum investment strategy for maximum environmental gains for minimum costs; prepare detailed proposals(v) produce a demonstration water management programme for the Aral Sear and use it to introduce scientists and engineers of the riparian states to modern river basin management tools.Researchers from e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Concept of ""World"" (Sattva-bhAjana-loka) in Indian Early YogAcAra Buddhism: An Intellectual History""' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Current scholarship on the philosophy of early Indian YogAcAra Buddhism (4th-5th centuries CE) has come under criticism for its de-contextualized understanding of the school's worldview. My research addresses this shortcoming through an intellectual history of the Yogacara's philosophical, cosmological and literary understanding of 'sattva-bhAjana-loka' (the sentient and insentient 'external world'), a fundamental concept that has not received adequate treatment in Scholarship to date.Understanding loka as a unique and pervasive social fact within the Yogacara worldview, this research will:(1). supply a genealogy of the Yogacara's understanding of loka by historically contextualizing it in the school's texts (Sanskrit, Tibetan, and Pali) and in the works of its Indian intellectual milieu.(2) Examine the ways in which the Yogacara's notion of loka - as an intersubjective, illusionary realm - is constructed by the imagery and metaphor of the school's shastric and sutra literature.Contextualizing philosophical analysis with cosmology and imagery, this interdisciplinary research aims to supply a more complete and nuanced picture of the Yogacara's worldview, which will in turn (1) contribute to the clarification of current debates over the schools core doctrines, and (2) contribute to an ongoing and increasingly influential interdisciplinary analysis of intersubjectivity, engaging Buddhist Studies, Philosophy of Mind and Phenomenology.Having recently returned from my doctoral studies at Columbia University in New York to assume a tenure-track position (starting in 2010) in Tel Aviv University’s East and South Asian Department, the IRG would enable me to conduct this research comprehensively (at two leading European research institutes, among other locations), leading to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European centre for theoretical studies in nuclear physics and related areas (ECT*)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Description:The European Centre for Theoretical Studies in Nuclear Physics and Related Areas (ECT*) offers a broad spectrum of dedicated and structured high-level activities for established and young researchers, theoretical and experimental physicists from all over the world (users). The scientific projects of ECT* are carried out under the responsibilities of the Board of Directors (Selection Panel) and with the supervision of the Director (Project Manager).The Board of Directors conceives the scientific strategy of the Centre, implements the consequences and co-ordinates the resulting projects and activities. The Centre is based in Villazzano (Trento, Italy) in a property called Villa Tambosi. It offers ample office space and conference halls, different meeting rooms, a library and a canteen. Furthermore the Centre is equipped with computing and networking facilities, able to serve a wide range of needs, including high-performance parallel computing with a new cluster configuration.Application:Any ECT* Activity is open to all qualifying people (users also called participants), but is however limited by capacity control and a selection procedure. People wishing to participate can either contact the project co-ordinators or the Project Manager, the Director of the ECT*, directly. Each activity and its closing dates will be announced separately on our web-site (http://www.ect.it).Project Manager:Wolfram Weise, European Centre for Theoretical Studies in Nuclear Physics and Related Areas, Strada delle Tabarelle, 286, Villazzano (TN) 38050, ItalyTel :+39-046-1314722/35Fax: +39-046-1314747E-Mail: rachel@ect.unitn.it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Femto- and attosecond imaging of molecular multiple ionization: Time-resolved electron and nuclear dynamics using free electron lasers and ultra-short pulses' (ATTOTREND).

assistant: **Concept**

The advent of ultrafast laser technology in the xuv and x-ray domains, by means of free-electron lasers and high harmonic generation, has opened the path to novel experiments at femto and attosecond time scales with direct applications on Chemistry and Atomic and Molecular Physics. These advances allow one to track in real time ultrafast electronic and nuclear dynamics induced by electromagnetic radiation. This largely unknown dynamics is at the focus of the proposal. Interpretation of ultrafast time-resolved experiments necessarily involves state-of-the-art time-dependent theoretical methods, together with advanced supercomputing resources. This remains a challenge due to the computational difficulty to include all electronic and vibrational degrees of freedom and the added complexity related to a multi-body Coulomb break up problem. ATTOTREND aims to develop a new theoretical tool based on time-dependent ab initio methods to account for the full dimensionality of the problem. Numerical methods combined with recently developed techniques to extract information from time-propagated wave-packets will be implemented. In particular, we seek to perform the first ever ab initio calculations on multiphoton double ionization of the hydrogen molecule including the dissociative channel. The second aim of this proposal is to carry out XUV attosecond pump-probe studies on molecules leading to single and double ionization. Double ionization processes are ideal to explore electron correlation and dynamics, and therefore to acquire a deeper knowledge of the basic mechanisms that governs the physics arising at the attosecond time scale. Finally, by combining these time-dependent methods with existing quantum chemistry tools, ATTOTREND also aims to explore these processes on more compl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Time, space and speed: cdGMP signaling in cell behavior and reproduction' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Bacterial biofilms are the primary cause of chronic infections and of resulting infection relapses. To be able to interfere with bacterial persistence it is vital to understand the molecular details of biofilm formation and to define how motile planktonic cells transit into surface-grown communities. The nucleotide second messenger cyclic di-guanosinemonophosphate (cdGMP) has emerged as a central regulatory factor governing bacterial surface adaptation and biofilm formation. Although cdGMP signaling may well represent the Achilles heel of bacterial communities, cdGMP networks in bacterial pathogens are exquisitely complex and an integrated cellular system to uncover the details of cdGMP dynamics is missing.To quantitatively describe cdGMP signaling we propose to exploit Caulobacter crescentus, an organism with a simple bimodal life-style that integrates the sessile-motile switch into its asymmetric division cycle. We aim to: 1) identify the role and regulation of all diguanylate cyclases and phosphodiesterases that contribute to the asymmetric cellular program with the goal to model the temporal and spatial distribution of cdGMP during development; 2) identify and characterize cdGMP effectors, their downstream targets and cellular pathways; 3) elucidate how cdGMP coordinates cell differentiation with cell growth and propagation; 4) unravel the role of cdGMP as an allosteric regulator in mechanosensation and in rapid adaptation of bacteria to growth on surfaces; 5) develop novel tools to quantitatively describe cdGMP network dynamics as the basis for mathematical modeling that provides the predictive power to experimentally test and refine important network parameters. We propose a multidisciplinary research program at the forefront of bacterial signal transduction that