RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Immunome project consortium for AutoInflammatory Disorders' (ImmunAID), addressing dissemination and exploitation.

assistant: **Impact**

Systemic autoinflammatory diseases (SAID) encompass several rare disorders characterised by extensive clinical and biological inflammation. SAID are caused by the dysregulation of the innate immune system. Due to numerous and unspecific symptoms, tentative diagnosis often leads to failure/delay and inadequate treatments. ImmunAID will deliver a method for rapid and accurate diagnosis across all the spectrum of SAID, in order to improve clinical management of SAID patients. Thanks to parallel analyses run on samples from more than 600 patients with monogenic or undiagnosed SAID collected throughout Europe, Immunaid will generate a unique and comprehensive set of data, based on unbiased multiomics approaches (gene, transcript, protein, microbiome), and hypothesis-driven assays exploring inflammasome, inflammation resolution and immune networks. A centralised data management strategy will enable to conduct integrated analyses for diagnostic biomarker identification. In a discovery phase, semi-supervised clustering of omics data will be combined to supervised analysis of pathway-related data to provide robust classification and strong link to clinical features/impact. The related biomarkers will further be validated externally on independent samples and cohorts. Overall, ImmunAID will disentangle the spectrum of SAID, and propose a new omics- and pathogenesis-based SAID classification associated to a clinical decision making algorithm implementable in daily practice. An efficient dissemination plan will target e.g. guideline-forming bodies, the medical community and patients with the help of the ERN RITA and with the objective of turning our results into clinical practice. To further support this, proactive innovation management will be implemented. To reach its ambitious g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Bacterial Degradation of Marine Particles: Colonisation, Dispersal, and Impact on Vertical Export in the Ocean' (BacPac), addressing dissemination and exploitation.

assistant: **Impact**

Sinking of organic particles from the ocean’s productive surface layers is a key component in the biological carbon pump, and essential to carbon sequestration by the ocean. Its regulation needs to be comprehended in order to accurately determine the oceans’ role in the global climate system. The impact of bacterial degradation on the fate of marine particles demands further study in order to significantly strengthen our understanding of oceanic carbon cycling. By investigating the prokaryotic community composition of suspended and sinking marine particles, the degradation activities of different prokaryotic groups, and colonisation of particles, BacPac will provide new knowledge elucidating the role of bacteria in vertical flux regulation.The project will use state-of-the-art molecular tools (DGGE, ARISA, and 454-pyrosequencing) to determine the prokaryotic community in ambient seawater, on marine particles (zooplankton faecal pellets, algal aggregates and marine snow), and on sinking particles collected by sediment traps. The main sampling activities in the Mediterranean Sea will be supplemented by field collections from North-Norwegian and European Arctic waters. The project combines the researcher’s expertise on vertical export and the host's expertise in marine microbial ecology in order to advance both disciplines.BacPac’s objectives are directly relevant to contemporary research in marine carbon cycling and microbiology, and will contribute to strengthening European scientific expertise in these fields. The proposed activities will advance both the scientific and complimentary skills of the researcher and will be an important step in his career development. The mobility (University of Tromsø, Norway, to the Marine Science Institute in Barcelona, Spain) will be be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A “Universal” Influenza Vaccine through Synthetic, Dendritic Cell-Targeted, Self-Replicating RNA Vaccines' (UniVax) targeting Seventh Framework.

assistant: **Abstract**

Although vaccination is the cornerstone of prophylaxis, current vaccines provide only moderate protection. Most employ inactivated or protein-based, including multimeric antigen, vaccines requiring annual updating. Their limited antigen loads provide limited capacity for inducing robust immune defences, without assurance that both humoral and cell mediated (CMI) responses, as well as durable immunity, will be induced. Replicating vaccines may provide several rounds of antigen production, increasing potential for humoral and CMI defence induction. Neither live, attenuated nor vector vaccines can be produced synthetically, being reliant on cell culture or egg production. They cannot be targeted to immune cells; interference from pre-existing immunity is also a risk.Efficacious, synthetic vaccines would be the answer, as seen with self-replicating RNA replicon (RepRNA) technology – these replicate and translate without producing infectious progeny. RepRNA produced in vitro is combined with synthetic delivery vehicles targeting dendritic cell (DC) receptors –essential for efficient immune defences– with glycoconjugate ligands. The UniVax project promotes the first synergising of approaches with synthetic targeted delivery systems for RepRNA. The innovation integrates technologies of (i) RepRNA vaccines, (ii) lipoplexes (biodegradable lipid/adjuvant/RNA for cytosolic delivery), (iii) polyplexes (biodegradable, polysaccharide vehicles), (iv) glycoconjugates targeting DC receptors, (v) adjuvants with well-defined molecular targets and effector functions. This promotes efficacious mucosal and systemic responses, ensuring for the first time both humoral and CMI responses. Components developed in PANFLUVAC and Replixcel projects allow UniVax to create the first Universal” Flu vac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NEW Business models for ITS' (NEWBITS), addressing dissemination and exploitation.

assistant: **Impact**

The overall objective of the NEWBITS project is to provide with a deep understanding of the changing conditions and dynamics that affect and/or influence C-ITS innovations. New KPIs will be designed to feed reactive and network oriented value creation propositions that improve the collaborative decision-making process across the various stakeholders. This improved value definition must minimize the failures inherent to (C-) ITS innovation diffusion, evolve present business models, and identify effective incentives to accelerate (C-) ITS deployment.To support its main goal, the project proposes to apply a business ecosystem approach for (C-) ITS which acknowledges the context of economics of networks by introducing a higher conceptual level than that of individual organisations, focusing at how organisations create value within the context of the networks in which they interoperate. NEWBITS consortium will design and implement a holistic intelligence process that will gather key information and indicators on market, demand, stakeholder’s involvement and innovation diffusion for ITS and C-ITS.  Furthermore, the project will develop a tailored application of the Value Network Analysis (VNA) business modelling method, which enables to model value networks, either internal or external to the organizations acting in the business ecosystems. NEWBITS method will be applied at macro-level (ITS and C-ITS context and market) and the meso-level (upon 4 pre-selected case studies). NEWBITS will configure Communities of Interest to foster a fully integrated network approach to the business modeling and develop a web-based network platform to support the project approach. NEWBITS will formalise the enhanced understanding of the potential system benefits and fundamental economics of new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Disposable Point-of-Care DNA kit for Mycobacterium tuberculosis' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Tuberculosis Bacillus (TB) and poverty come together to perpetuate a vicious cycle. Poverty contributes to the spread of TB as people are forced to share close living quarters and are often in overall poor health. Simultaneously, costs associated with diagnosis and treatment create further hardship, both for patients and their families – including their children. Worldwide, TB creates hundreds of thousands of orphans, increases child malnutrition and forces many children to leave school in order to work or care for their family or because of the stigma associated with the disease. To stop the spread of TB globally, the world needs better TB diagnostics: rapid, practical and accurate in poor-resource, which is critical to ensure that people receive proper and timely treatment. This proposal aims to integrate an experienced researcher in clinical microbiology to fulfil the multidisciplinary team among STAB VIDA’s consortium of partners and coordinate the development of a cost-effective and appropriate new Point-Of-Care diagnostic assay (portable nucleic acid test using gold nanoprobes) that will contribute towards improved control of the global TB epidemic and improve the quality of patient care by addressing yet unmet clinical needs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Polarimetry of Anomalous Microwave Emission: Implication for B-mode Polarization Detection and Galactic Science' in the context of a Horizon 2020 call.

assistant: **Objectives**

Anomalous Microwave Emission (AME) is potentially polarized in the frequency range [1-100] GHz. The polarization properties of this astrophysical signal have to be characterized and understood completely for one willing to remove Galactic foregrounds in order to detect B-mode polarization for cosmology. The characterization of AME polarization properties is also fundamental in term of Galactic Astrophysics to understand the mechanisms producing the AME. The PolAME project aims to use the QUIJOTE-CMB experiment and its two instruments (the MFI and the TGI) for measuring the degree of polarization of the AME in the domain range [10-30] GHz on a sample of selected sources. This new data, in addition to new C-BASS data and the WMAP and PLANCK maps and ancillary data will be compared to theory and state-of-the-art modelling results. The Galactic science community will greatly benefit the new advances that will be provided by the PolAME project. The main outcome of this project will lead to a stronger characterization of the Galactic Polarized Foregrounds which is fundamental for cosmology. Knew knowledge will be produced about our understanding of the nature of the AME and dust grain evolution processes in our Galaxy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Exploration of targeting GPR56 and its cancer cell ligand as a novel immune checkpoint inhibition strategy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy over the last decade. In essence, ICIs block the interaction of immunosuppressive receptors and their ligands, which attenuate T cell activity and the secretion of pro-inflammatory cytokines. Blocking these inhibitory signals results in the release of immunosuppression and promotes anti-tumor T cell reactivity.Unpublished data from our research group, emerging in collaboration with the biotech company InProTher suggests a novel immune checkpoint receptor-ligand pair consisting of an adhesion G protein-coupled receptor (GPCR) and a viral protein.With therapeutic targeting of GPCRs being our main focus, we - together with our collaboration partner InProTher - aim to investigate the blockade of the interaction between immune cells expressing the adhesion GPCR and cancer cells expressing the viral protein as novel ICI and cancer therapy strategy. The exploration of novel immune checkpoints and expanding the repertoire of cancer therapy drugs are paramount for overcoming therapeutic resistance and advancing cancer treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Music as youth empowerment: creating connection to self and others', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Can music solve global challenges, lead to improved connection and empowerment, foster an inclusive society? I introduce music engagement as a ubiquitous daily resource to advance a critical capacity in a modern world: youth ability to connect with self and others. The challenge of assessing music as a human resource is that it functions at emotional, bodily, and situated levels of experience that are difficult to objectively measure. However, such aspects are integral to state-of-the-art conceptions of human cognition and, further, advancements in empirical research now enable their quantitative assessment. In MUSICONNECT, I will conduct groundbreaking research to address the emotional-bodily-situated nature of music, to conceptualize and objectively measure how, when, and for whom music engagement functions as empowerment. Three dialogical work packages will address music as 1) emotional self-regulation 2) embodied interaction and 3) situated engagement. Young people (N = 5000, aged 15-25) with diverse backgrounds will participate in studies ranging from surveys to experiments. I will implement and develop cutting-edge methods to quantify the “unmeasurable” of music: ecologically valid experience sampling of real-time listening experiences, physiological measures, computational music feature analyses, optical motion capture, deep learning techniques (deep pose estimation), digital ethnography, and psychometric assessment. Results will revolutionize the scientific capacity to address music engagement as testable, falsifiable, and evidence-based practice. Breakthrough knowledge will be created on the mechanisms of action through which music functions as empowerment and how the effectiveness of this is determined by the interplay of musical, individual, situational, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'The role of the frontal cortex in planning decision making and problem solving'.

assistant: **Objectives**

The prefrontal cortex is phylogenetically the most recent region of the brain, and this structure reaches its highest level of development in humans in whom it represents about one third of the cerebral mass. Yet, the specific functions of the frontal lobes remain poorly understood, and are currently a topic of intensive research effort in neurosciences. Anatomical and neurophysiological investigations as well as studies of human patients and non-human primates with frontal lobe dysfunction, indicate that the prefrontal regions are a site of supramodal integration and that they play an important role in sequentially and hierarchically organized behaviors. It is becoming increasingly clear that multidisciplinary approaches are necessary in order to clarify the neural and cognitive organisation which govern such complex behaviors. The present study focuses on what is thought to be a major function of the frontal lobes in humans, namely the planning of action, using three coordinated research methods. The first method focuses on planning and executive capacities of patients with primary and secondary dysfunction of the prefrontal regions. The second method uses functional brain imaging in intact human subjects to identify the regions involved in planning. The third method uses artificial neural networks to simulate temporally organised actions and and develop a testable model of neural organisation in order to account for normal and pathological planning. The major working hypothesis is that the prefrontal regions and the subcortical areas connected to it, such as the basal ganglia, constitute the substrate of higher-order cognitive representations which serve to initiate, steer and supervise ongoing behavior. The rationale for the experiments described in this project has
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multimodal imaging of lung tissue based on LIBS, MALDI and histology fusion to unravel sarcoidosis causes' in the context of a Horizon Europe call.

assistant: **Objectives**

Sarcoidosis is an inflammatory, granulomatous disorder with unknown cause highly associated with occupational exposures. It has   geographically variable prevalence, with an elevated cost for the patients. It can be detected among metal-exposed workers, firefighters, rock, glass wool or agriculture workers. The most prominent example being rescuers in the World Trade Center in 2001. The need for accurate information about the exposures and causes of sarcoidosis is a limiting factor for clinicians, therefore, supplying them with relevant information will improve the patient's healthcare trajectory.The aim of imATLAS project (IMaging Analysis of Tissues via LAser Spectrometry) is to develop a novel multi-analytical procedure based on LIBS and MALDI-MSI, in combination with standard histology, to identify, localize and relate exogenous and endogenous agents allowing to elucidate possible external causes and biomarkers of sarcoidosis. A data analysis pipeline will be created containing all the bio-statistical steps, graphical representation, exposure and biomarker search approaches, as well as the image fusion results, to provide a global view with elemental and molecular information of the tissue, in addition to the pathologic information provided by histology. The scripts will be publicly accessible, available to other researchers as well as widely adaptable to different imaging techniques and instruments. Furthermore, the results obtained will be released as an easy-to-read file (Quicklook) to present all the useful multimodal analytical information to clinicians and optimize the diagnosis and treatment of patients.


**Keywords:** LIBS; MALDI-MSI; Imaging; Data Fusion; Sarcoidosis;  Occupational Disease
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Glycoprotein (Glyco+protein) of the biomineralized eggshell in birds' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Bird eggshell is a remarkable specimen for proteins analysis in archaeology and palaeontology as it can be used to understand how biominerals form and how they survive into deep time and elucidate phylogeny of the extinct birds. Proteins are known to survive best in association with minerals and proteins can persist in >6 million years old eggshell. Protective shell of eggs serves a crucial role for birds terrestrial adaptation as eggshell provides physical barrier to protect embryo, prevents desiccation during embryonic development, allows gas diffusion and provide calcium source for embryonic bone development. Organic matrix of eggshells is mainly made up of glycoproteins (glycan (sugar) + protein). The glycan study in archaeology and palaeontology is scarce and the application of glycoproteomics and glycomics in ancient eggshells will be a milestone in science, opening a new avenue to analyse sugar. The glycoprotein role in eggshell remains elusive and the GlycoEggshell project intends to describe and investigate specific roles of glycosylation on eggshell proteins across birds and evolutionary time, using modern and sub-fossil samples. GlycoEggshell project has three research objectives: characterise the glycosylated proteins in eggshells, identify the compositions and structures of the glycosaminoglycan (GAG), and determine the GAG-protein interactions. The modern eggshell from diverse bird clades will be used for glycoproteomics analysis to assess the glycosylation status among birds. Glycomics approach will be used to identify the GAG structures and compositions across modern and sub-fossil eggshells while the novel cell-based glycosaminoglycan array developed by my supervisor team in Copenhagen Center for Glycomics will be used to elucidate the interactions of p