RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Wireless Friendly Energy Efficient Buildings'.

assistant: **Innovation**

The wireless performance of building design is not understood and the construction industries do not consider wireless system performance in their designs or specifications despite the rapid employment of metal skins and windows and facades containing metallised layers for energy conservation, both of which are a significant problem for wireless signal propagation. Hence there is a significant need to understand the performance of buildings and construction materials for efficient energy consumption and for the efficient propagation of radio waves. This project’s objectives are to develop and verify the new concept of the wireless friendly, energy efficient building. The wireless propagation properties of building and insulation materials must be assessed. The same properties must be measured for building structures such as walls (internal and external), floors, facades and window systems. These properties will be evaluated from 400 MHz to 20 GHz to include both current and future wireless networks and systems. A significant part of this project is the development and optimisation of CAD tools that combine wireless propagation models with energy efficiency models producing a complete model for the built environment. New innovative construction materials such as glass and steel fibre reinforcement will be studied and new architectural designs investigated to improve wireless signal propagation while maintaining energy efficiency. The project will address how existing buildings can be reconfigured in addition to showing how new buildings can be designed for wireless and energy efficiency.Several case studies will be modelled including a secure building, a smart home including smart energy metering, the use of intelligent reconfigurable structures and a mixed use shopping/
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Transgenic animal models to study the mechanisms that lead to non-insulin dependent diabetes mellitus'.

assistant: **Innovation**

Research objectives and content Non-insulin-dependent diabetes mellitus (NIDDM) is the most common metabolic disease in humans and the prevalence of this disease is increasing in Europe. Dr. Fatima Bosch's group have developed several transgenic animal models to study the pathophysiological causes of NIDDM. One of them is a model that overexpresses phosphoenolpyruvate carboxykinase (PEPCK) in the liver. In these transgenic mice, the resulting hepatic overproduction of glucose lead to insulin resistance and obesity. Using this model, I aim to determine the role of chronic hyperglycemia in the alteration of pancreatic ss-cell function, fat accumulation and muscle insulin resistance . Other models overxpressing PEPCK, in the liver and adipose tissue, or in adipose tissue alone will also be studied. The interaction of the liver with other tissues like fat, muscle and pancreatic ss-cells will also be examined.  Training content (objective, benefit and expected impact) I have studied the regulation of PEPCK gene expression in adipocytes. This approach helps us to understand the molecular mechanisms of transcriptional regulation. However, the development of transgenic models is essential if this type of study is to be extrapolated to the pathophysiological context. The host laboratory is very competent in this domain and is ideal to further my training.  Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Understanding and Postponing Yeast Death to Improve Production' in the context of a Horizon Europe call.

assistant: **Objectives**

Yeasts are model organisms for eukaryal cell biology studies but are also used to sustainably produce a large variety of compounds. Although unicellular, death spares no one and yeast can undergo regulated cell death (RCD) in response to a wide variety of intra and extracellular signals. In industrial processes, the occurrence of yeast RCD negatively impacts yields and production rates. How yeast cells die under these conditions is however hardly studied nor understood. UPsYDe aims to decipher how yeast cells die under industrial conditions and engineer RCD pathways to postpone cell death and improve production, while simultaneously training the 13 doctoral candidates needed to tackle this kind of challenges. This requires a synergetic approach combining fundamental cell biology, bioprocess engineering, yeast physiology, and systems and synthetic biology. Four different yeast species, Saccharomyces cerevisiae, Komagataella phaffii, Yarrowia lipolytica and Debaryomyces hansenii, will be studied and engineered in a consortium of 7 beneficiaries and 15 associated partners varying from start-up companies to major biotechnology industries. This consortium offers all the expertise and methodology needed and provides the DCs with a highly diverse, multidisciplinary and intersectorial training plan across Europe. Expected outcomes are novel (rapid) screening techniques to detect cell death phenotypes on site, advanced genome-scale metabolic models, improved yeast strains and more sustainable and profitable yeast bioprocesses. In addition, UPsYDe will deliver the next-generation scientists capable of integrating different knowledge fields to lead the full transition to a sustainable bioeconomy, in academia or industry.


**Keywords:** Yeast, bioprocess engineering, regulated cel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Interdisciplinary European Postdoctoral Fellowships at LEAPS Facilities' (2021-2027).

assistant: **Concept**

The LEAPS ULTRAFAST Programme presents an unparalleled opportunity for 57 postdoctoral researchers to engage in groundbreaking research and advanced training across renowned international research facilities in the field of Ultrafast Science. DESY and its partners within the League of European Accelerator-based Photon Sources (LEAPS) offer a unique combination of research tools, especially in terms of table-top and large-scale light sources, enabling the decoding of matter at the smallest length scale and the fastest time scale.Fellowships will be offered at eight excellent facilities located in France, Germany, the Netherlands, Spain, Sweden, and Switzerland. The manifold synergies among the LEAPS ULTRAFAST partners will be employed to train the next generation of scientists. Fellows will be guided to leverage the full potential of European light-source facilities while transferring knowledge and stimulating innovation. The competitiveness of European research and technology rely on the education and career development of these experts, both in Academia and Industry.The training programme offers Fellows broad guidance both for their own scientific project and for the next career steps—be it in academia, industry or founding a start-up company. It focuses on i) their scientific progress and prospects, ii) transferable skills and entrepreneurial knowledge, and iii) modern safety courses. A pool of carefully selected supervisors and mentors, equipped with modern mentoring tools, will support the Fellows. The outcome of this programme will be a modern and sustainable career and training platform that will benefit many research infrastructures in Europe. The professional and personal development of the Fellows will also be sustainably driven towards their individual goals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Customer related water supply management and optimisation'.

assistant: **Innovation**

Benefit for research fellow: The obvious interest for the subject of the CARE- W project, joining more that 20 partners, illustrates that there is a great need for advanced training in decision support systems for water network management. This need will be met by establishing a Marie Curie Industrial host site in close collaboration with the CARE-W participants. The visiting research fellows will participate in broad-scaled, market-related and international oriented state-of- the art research and development in one of Europe's most potent public water R&D teams. Through various international projects they will have opportunity to establish contact to other leading European research organisations. Some of the expected benefits are:1. Training on simulation tools 2. Training on water management methods, exploring how different tools affect management strategies 3. Training on interaction of raw water quality, treatment and water quality processes in network 4. Pipe inspection and rehabilitation technologies Benefit for Industry: Testing and verification of methods and models developed or under development at SINTEF. Potential establishment of long-term collaboration and customer relations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Scenarios for reconciling biodiversity conservation with declining agricultural use in the mountains of europe' (BIOSCENE), addressing dissemination and exploitation.

assistant: **Impact**

Europe's mountain biodiversity is central to Natural 2000 and the European Biodiversity Strategy. Decline in agricultural use in mountain areas has dramatic biodiversity consequences including threats to priority species and semi-natural habitats but also opportunities for reintroduction of large mammals and habitat restoration. The project objective is to develop and evaluate strategies for reconciling conservation of mountain biodiversity with declining agriculture. Options for conservation of priority species and habitats are configured into three conceptual policy scenarios; business as usual, managed decline and biodiversity enhancement. Biodiversity consequences are predicted using advanced ecological modelling. Scientific, economic and policy feasibility and public acceptability are evaluated through an innovative sustainability appraisal. Practical outputs are ensured through the participation of stakeholder panels.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Characterization of nuclear SHP2 function in breast cancer progression and metastasis' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Breast cancer is the most frequently diagnosed cancer in women with ~1.1 million worldwide cases. Despite intense study, in a significant fraction of women, tumor progression and disease relapse is inevitable underscoring a crucial gap in our understanding of these important hallmarks. Currently, little is known about the biochemical networks controlling these processes. The host lab has shown a fundamental role for the protein tyrosine phosphatase, SHP2, in tumor progression and metastasis in two aggressive breast cancer subtypes, human epidermal growth factor 2 (HER2) positive and triple negative breast cancer. Preliminary data in breast cancer cell lines revealed nuclear localization of SHP2 and proteomic analysis identified candidate nuclear substrates including nucleolin. However, whether a nuclear function of SHP2 and how SHP2 and its binding partners (i.e nucleolin) might impact breast cancer progression and metastasis remain unknown. This proposal will take advantage of original, state-of-the art technologies including multiphoton intravital imaging developed by the host laboratory to determine the nuclear function of SHP2 in normal mammary epithelial cells and during breast cancer progression and metastasis. Finally, it will validate nucleolin (and other identified candidates) as a SHP2 nuclear substrate and determine whether it is a critical downstream effector of SHP2 in breast cancer. Elucidation of the mechanisms driving tumor progression and metastasis is paramount for the development of novel therapeutic strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mitochondrial Assembly Disorders' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Impaired mitochondrial energy metabolism is recognized as an increasingly relevant cause of human disability in Europe, especially for infants and children.Besides mutations in the mitochondrial genome, mitochondrial disorders can be the consequence of mutations in numerous nuclear genes encoding factors involved in mtDNA maintenance and expression, and in the formation and regulation of the mitochondrial respiratory chain (MRC). In particular, mutations in genes encoding factors controlling the assembly o f MRC are responsible for severe, early-onset mitochondrial syndromes.However, in spite of the wealth of information gathered in recent years on the genetic basis of these disorders, neither the detailed molecular mechanisms leading to cell or tissue failure are known, nor are the metabolic consequences ultimately determining the clinical phenotype, completely understood.The aim of this project is to allow Dr. Erika Fernandez-Vizarra, a researcher with experience in Biochemistry and Molecular and Cellular Biology, to undertake training through research at the Istituto Nazionale Neurologico Carlo Besta in Milan, Italy, with a view to completing her expertise in the mechanisms of formation, structural modulation and functional control of MRC and mitochondria l homeostasis.In collaboration with the host, she will shed light on the normal function of, and pathogenic mechanisms due to mutations in three disease-associated MRC assembly factors, Surf1, BCS1L and COX15.The project will be implemented via a multidisciplinary approach including in vitro characterization of mitochondrial proteins, cell biology and cell imaging on normal and mutant cell lines, and in vivo studies based on the creation and investigation of recombinant animals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ghosts in parthenogenetic daughters  - epigenetic effects on clonal organisms can reveal the degree of phenotypic plasticity due to biotic cues' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

There is increasing awareness of the importance of epigenetics in regulating phenotypic properties relevant to the ecology and evolution of all organisms. For ages, the waterflea Daphnia, has served as a model organism for ecological, evolutionary and toxicological studies. The efforts and results from Daphnia investigations recently have been rewarded by the National Institutes of Health adopting this species as its 13th model organism suitable for biomedical investigations.  Now, it is emerging as a model organism for epigenetic research due to the wealth of information about ambient regulation of its evolutionary genetic responses to environmental cues. Best of all, Daphnia has a unique mode of reproduction, cyclical parthenogenesis, where under favourable conditions reproduces clonally. Yet males and sexual reproduction are inducible by environmental cues. Daphnia has a short generation time and should prove to be ideal for revealing epigenetic regulations when multigenerational exposure is of interest. As we share more genes with Daphnia than with any other invertebrate, knowledge of epigenetic regulation is of general relevance also for humans. Last 2.5 years, I maintain in culture several isoclonal lines of Daphnia (under different conditions) to understand the mechanisms of molecular responses to environmental challenges. I propose to take advantage of these unique resources to study how the transgenerational stressors due to environmental cues propagate on epigenetic markers of Daphnia, and how they modulate the expression of fitness-related traits. I will utilize unique clonal lines of Daphnia that have been exposed to different food (> 50 generations) as a point of departure for my studies. Together with epigenetic molecular tools, I proposed to develop a mec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Evolutive User-centric Networks for Intraurban Accessibility' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Urban transport is essential for citizens to perform their daily activities, but it also constitutes a major source of pollution. The goal of EUNOIA is to take advantage of smart city technologies and complex systems science to develop new models and tools empowering city governments and their citizens to design sustainable mobility policies.EUNOIA will pursue advances in three complementary directions:1. Use of data. The massive penetration of ICT is modifying social relationships and travel behaviour, and at the same time is providing us with a huge amount of heterogeneous data: intelligent transport systems, Internet social networks, mobile phone call logs, e-transactions. EUNOIA will investigate how to exploit these data to characterise mobility and location patterns in different European cities.2. Urban transportation models. EUNOIA will investigate the interactions between social networks and travel behaviour, e.g. the influence of social networks on the planning of joint trips. This will allow a more comprehensive assessment of mobility policies, particularly of new services emerging around the idea of a shared access to resources, such as car sharing. The new travel behaviour models will be integrated into state-of-the-art agent-based simulation tools.3. Link between modellers, decision makers, and societal actors. The potential of urban simulation models is still little exploited in policy decision contexts. EUNOIA will develop tools, e.g. 3D visual analytics, allowing stakeholders' interaction with the simulation results, as well as a methodology for collaborative, multi-stakeholder policy assessment.In order to ensure maximum credibility and usability of the project results, the models and methodologies developed by EUNOIA will be tested and refined through s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Working on the fringes: immigrant businesses, economic integration and informal practices' to be submitted under Fourth Framework.

assistant: **Abstract**

Summary-Immigrant businesses are crucial economic nodes in social networks of immigrants linking production and consumers in concrete organisational and spatial ways. These immigrant businesses can also be seen as potential primary nodes of informal activities. As in the wider economy, informal economic activity may sometimes involve criminal activities. The aim of the project is to create an innovative, multi-disciplinary trans-EU network. This network will focus on informal economic activities of immigrants as they may have significant implications for the process of socio-economic integration and, thus, of the social cohesion of the societies within the EU.- Immigrant businesses engaged in informal economic activities are, on the one hand, in breach of the law, but, on the other, they may provide immigrants with better economic opportunities. Policy makers, therefore, have a dilemma.- The international network will compare informal economic activities by taking immigrant entrepreneurship as the strategic starting point. The project entailsa comparison of the role of immigrant businesses in the underground economy as well as an assessment and evaluation of rules and regulations and existing policy approaches related to informal and criminal economic activities in European Union member states and an affiliated member.The following objectives will be addressed:- How has immigrant entrepreneurship evolved in the last two decades and what are the structural determinants of the observed trends in the selected countries- What kind of profiles of informal economic activities do the immigrant entrepreneurs display? How are they related to activities in the mainstream economy on the one hand, and, on the other, to the regulatory framework (in particular the welfare state) and