RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Automated process for stable preservative free pastry base mix for high added value bakery goods to increase the competitiveness of SME bakeries' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The proposed research will develop a technical solution that will relieve some of the more mundane tasks associated with producing higher value baked goods and enable SME bakeries throughout Europe (190,000) increase their efficiency and be more competitive against the threats from industrial bakeries and supermarkets. The SME-AGs within this SME dominated sector and through their leading role in this project will enable the results from this proposed development to be brought to the benefit of a significant number of SME bakeries most effectively. This will result in SME-AG members using the technology to increase profit to over €40 million per annum in the first 5 years of this post project commercialisation To achieve this, the following technical objectives will be met: 1. Process control & automation. Rheological sensor system to detect, qualify and quantify the point of time for finishing the roasting process for automatic process control (± 15 seconds). To enable immediate automated response for step changes in viscosity in dough. Rheology changes reflect key stages in dough formation. 2. Process automation, enabling non-manual contact with food material after controlled ingredient metering. 3. Automatic CIP (clean in place) system, for rapid cleaning between batches. 4. The development of an aseptic pastry manufacturing system, with a novel aseptic filling and packaging system to enable subsequent chilled storage and distribution after the heating process step with microbiological integrity. 5. Shelf life stability of choux pastry mixes (16-24 weeks at 4 C°). Organoleptic comparison by trained taste panels will be regularly undertaken to validate no significant variation from traditional manual production of same recipes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Organic phases in cells: Elucidating the physical nature of biological liquid droplets' (BlobMech).

assistant: **Concept**

Recently it has emerged that ‘membraneless organelles’ a commonly encountered body for compartmentalisation in Eukaryotic cells that include ‘nucleoli’ and ‘stress granules’, are phase separated liquid droplets suspended inside cells, formed from highly mobile disordered proteins. My research has focused on the prediction from physical theory, that the interior of liquid droplets should have very different chemical properties to the exterior dilute phase. By quantitatively analysing model biological liquid droplets formed by the Ddx4N1 protein, we discovered that their interior resembles an organic solvent (DMSO), can melt double stranded DNA, and selects which proteins can enter based on a simple sequence-based algorithm, akin to a chemical solubility rule.The field of biological liquid droplets has largely focused on phenomenological observations. This proposal aims to step beyond this and test the central hypothesis that “intermolecular interactions drive biological liquid droplet formation to create regions of solvent tailored to promote specific chemical functions”. By studying a diverse range of biological liquid droplets, I seek to establish that physico-chemical properties explain both when liquid droplets mix and when they do not, explain which molecules are absorbed and which are not, use these features to predict new properties to design new functionalised sequences using rules based on their fundamental inter-molecular interactions, determine structures of the liquid droplets using NMR and cryo-electron tomography and investigate the effects of liquid droplets on chemical reactivity. This research has the potential to change our understanding of the mechanisms of biochemistry, and use principles from physical chemistry to explain why cells naturally create t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Matching CNS Lineage Maps with Molecular Brain Tumor Portraits for Translational Exploitation' under Horizon 2020.

assistant: **Concept**

Brain tumors represent an extremely heterogeneous group of more than 100 different molecularly distinct diseases, many of which are still almost uniformly lethal despite five decades of clinical trials. In contrast to hematologic malignancies and carcinomas, the cell-of-origin for the vast majority of these entities is unknown. This knowledge gap currently precludes a comprehensive understanding of tumor biology and also limits translational exploitation (e.g., utilizing lineage targets for novel therapies and circulating brain tumor cells for liquid biopsies). The BRAIN-MATCH project represents an ambitious program to address this challenge and unmet medical need by taking an approach that (i) extensively utilizes existing molecular profiles of more than 30,000 brain tumor samples covering more than 100 different entities, publicly available single-cell sequencing data of normal brain regions, and bulk normal tissue data at different times of development across different species; (ii) generates unprecedented maps of normal human CNS development by using state-of-the art novel technologies; (iii) matches these molecular portraits of normal cell types with tumor datasets in order to identify specific cell-of-origin populations for individual tumor entities; and (iv) validates the most promising cell-of-origin populations and tumor-specific lineage and/or surface markers in vivo. The expected outputs of BRAIN-MATCH are four-fold: (i) delivery of an unprecedented atlas of human normal CNS development, which will also be of great relevance for diverse fields other than cancer; (ii) functional validation of at least three lineage targets; (iii) isolation and molecular characterization of circulating brain tumor cells from patients´ blood for at least five tumor entities; and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Probing the mysteries of sweet “on-off” switches of the human immune system: toward the development of novel glycomimetics against bacterial infections' to be submitted under Horizon 2020.

assistant: **Abstract**

Glycans are directly involved in the normal physiology and in the etiology of several major diseases, spanning from bacterial and viral infections through to cancer and autoimmune disorders. Thus, deciphering the glycome holds huge promise to provide new targets and diagnostics for human health. Despite the tremendous advance of knowledge in the field of Glycoscience during the last decade, the comprehension at high resolution of the molecular basis of many pathogen-mediated diseases is still incomplete. GLYCOSWITCH will significantly contribute to fill this gap, providing a holistic picture of the manifold mechanisms of host responses to microbial infections, with a special focus on Gram-negative bacteria. I propose to address bacterial glycans recognition by host immune proteins by using a multidisciplinary approach, combining state-of-the-art synthetic organic chemistry, molecular biology, biochemistry and biophysics techniques, massively including NMR spectroscopy. I will apply them in an innovative integrated chemical biology approach in order to decipher key glycan recognition aspects beyond current knowledge. Understanding of molecular mechanisms of detection of invasive virulent bacteria by host organisms will allow to reach the ultimate goal of GLYCOSWITCH project: the design and development of novel and effective glycomimetics able to modulate the function of host immune receptor proteins. The success of GLYCOSWITCH will unlock attractive opportunities for the development of host-directed strategies to boost the immune response or reverse pathogen-induced immunosuppression.My unique approach to this project, as an organic chemist with wide expertise in NMR and bacterial glycans, will provide groundbreaking information on protein-glycan interaction systems of p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Partnership for the Development of Cognitive Radio'.

assistant: **Concept**

By the year 2020, mobile and wireless communications will play a central role in all aspects of European citizens’ lives. As more devices “go wireless” and human wireless networks proliferate at unprecedented speed more bandwidth and better use of the RF spectrum will be required to avoid future “wireless traffic jams”. In this context the realisation of cognitive radio (CR) is essential to meet the requirements of future wireless communication infrastructures. Software-defined radio (SDR) should be a step on the path towards CR. Par4CR brings together a consortium of seven major European players to perform a joint research programme and exchange knowledge on technologies crucial for the development of software-defined radio and cognitive radio. Based on the joint research programme the partners will implement an intensive exchange programme. In the context of Par4CR 29 researchers will spend up to 16 months working within a research team of another partner, involving in total 121 person months. Targeted recruitment of six experienced researchers will complement the knowledge available within the consortium, involving 120 person months. Furthermore during Par4CR the consortium will organise 4 two day workshops, actively involving external researchers in the progress of the research programme. By the end of Par4CR an international conference will be organised to actively disseminate lessons learned. The overall goal of the research programme of Par4CR is to develop a new architecture for software-defined radio as a step towards cognitive radio based on wideband operation of transmitter and receiver. It is anticipated the research programme will result in the following main innovations: - cost reduction of SDR to a level below multi-mode multi-band transceivers; - perform
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Identification and characterization of novel genetic defects in unsolved Congenital Disorders of N-glycosylation type II (CDG-IIx) patients'.

assistant: **Concept**

Glycobiology is considered as an emerging field of biology and the importance of complex carbohydrates in health and disease is increasingly recognized. In the last decade, a new group of diseases related to defects of glycosylation and called Congenita l Disorders of Glycosylation (CDG) has been identified. CDG can be divided into two groups according to the molecular defects, CDG-Iand CDG-II. Group I disorders relate to defects in the synthesis of the N-glycan in the endoplasmicreticulum.This project relates to Group II disorders, which arise from the defects in the processing of the glycans, mainly in the Golgi apparatus. Given the complexity and the large number of enzymatic steps involved in protein glycosylation in this compartment, the number of unsolved cases of CDG-II(CDG-IIx) has considerably increased. The INOV-CDG project aims to identify and characterize novel genetic defects in these CDG-llxpatients. This will be done by a multidisciplinary approach, which includes: The characterization by novel techniques of abnormal glycans structure in these patients, to pinpoint the defective step(s) and select the candidate gene(s). The systematic screening for mutations in these genes or gene-families. The functional analysis, in expression studies or complement at ion assays of the pathogenic nature of the mutation(s). In addition, we propose a novel hypothesis for defects that may derive from a mislocalization of the culprit glycosyltransferases.This project combines knowledge from the genetics and glycobiology, to further the understanding of the molecular and biochemical basis of a group of rare disorders. It fits within the objectives of the thematic area Combating, cardiovascular disease, diabetes and rare diseases" and is specifically aiming at bringing the ba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'aGent Oriented Zero Defect Multi-stage mANufacturing'.

assistant: **Innovation**

Multi-stage manufacturing, which is typical in important industrial sectors such as automotive, house hold appliance and semiconductor manufacturing just to name few, is inherently complex. The main idea of GO0D MAN project is to integrate and combine process and quality control for a multi –stage manufacturing production into a distributed system architecture built on agent-based Cyber-Physical Systems (CPS) and smart inspection tools designed to support Zero-Defect Manufacturing (ZDM) strategies. Data analytics tools provide a mean for knowledge build-up, system control and ZDM management. Real time and early identification of deviations and trends, performed at local level, allow to prevent the generation of defects at single stage and their propagation to down-stream processes, enabling the global system to be predictive (early detection of process faults) and proactive (self-adaptation to different conditions).The GO0D MAN project is based on the results of previous successful EU projects and integrates them to realize and deploy a Zero Defect Manufacturing framework for multi-stage production lines, in collaboration with industry partners, a system integrator, two technology providers and three end users. The use cases are representative of key European industrial sectors and have different types of multi-stage production systems: the first use case concerns highly automated serial mass production of automotive components, the second use case is about batch production of high precision mechanical components for automotive electro valves, the third use case produces professional customized products such as ovens for restaurants. Successful completion of this project will provide a replicable system architecture for ZDM. The results will be broadly applicable in a v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Distributed Cloud product specification and supply chain manufacturing execution infrastructure' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The objective of the ManuCloud project is the development of the service-oriented IT infrastructure “ManuCloud” as basis for the next level of manufacturing networks by enabling inter-enterprise integration down to shop floor level. R&D Approach The ManuCloud IT infrastructure will consist of a set of services providing knowledge-based product specification based on the actual available manufacturing capabilities of the network, inter- enterprise data exchange, and inter-enterprise quality assurance. Additionally a highly agile intra-fab integration environment capable to automatically propagate manufacturing capabilities and manufacturing process data to the ManuCloud infrastructure will be developed. ManuCloud aims at bringing impact in the broad field of industrial manufacturing. Therefore ManuCloud does not targeting a specific industry, the concept will be applicable to all types of networked manufacturing. Impact and relevance of the project for a specific use case, but also in general, will be demonstrated by an industrial proof-of-concept. Industrial relevance is guaranteed by involving a strong industrial European key player, the Robert Bosch AG, as driver of the development and as end-user . The company has lately entered the photovoltaic industry and is actually investing in multiple companies in this domain. Several manufactures of innovative organic semiconductors are taking part in the project and will serve as testbed for the proof-of-concept ACP-IT and nxtControl will provide their knowledge in shop floor IT technologies. The scientific relevance is ensured by bringing together leading European institutes from the manufacturing engineering and automation, the organic semiconductor manufacturing, the supply chain management, the knowledge-based product sp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'What is bedouin-type Arabic? The linguistic and socio-historical realities behind the millennia-old dichotomous concept of nomadic and sedentary people in the Middle East and North Africa', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This project will investigate the linguistic differences between originally nomadic and sedentary people, i.e. one of the key concepts in the history of the Arabic language and the grouping of its contemporary spoken varieties. While the dichotomy between Bedouins and sedentary communities is of crucial importance for the (social) history, economy, and linguistic identity of the Arabic speaking Middle East and North Africa, it is still insufficiently understood. WIBARAB aims to establish for the first time a robust set of linguistic phenomena that characterize the bedouin-sedentary split. To this end, it not only considers (1) phonological and morphological features as hitherto has been done, but also (2) typology, grammaticalization pathways, syntax, phraseology, and lexicon, and (3) the influence of intra-dialect contacts and historical migrations.  WIBARAB will provide new data from three under-researched Arabic varieties and investigate linguistic attitudes towards bedouin-type dialects on the basis of five case-studies with different social and geographical settings. Its holistic approach challenges well-established views and methodically shows how diachronic linguistic data can provide proxy data for history and vice versa. WIBARAB also studies the impact of social settings, particularly tribal and patriarchal structures, as possible factors for the linguistic conservatism of contemporary bedouin-type Arabic. It includes recent findings in human genome analysis where appropriate and ethically acceptable, and makes ample use of the possibilities provided by digital humanities. WIBARAB adopts methods grounded in general linguistics, sociolinguistics, and historical interpretation to shed light on a phenomenon of fundamental importance in the history and the present
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Recycling of eaf dust by an integrated leach-grinding process', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Steel producers in Europe have maintained global competitiveness by using mini-mills with electric arc furnaces (EAFs) to make steel. However, during the recycling process, zinc and other non-ferrous metals, present in the scrap metal, as well as some of the iron, are evaporated" forming minute particles of the oxides of these metals. Increasing levels of zinc in scrap steel are forecasted due to the increased use of galvanized materials in automobile manufacture. The objective of this project is to develop a "cold" process to remove the heavy metals, as well as the zinc oxide, from the dust and use the remaining inert material as e.g. construction material. However, earlier efforts in this direction have so far not been entirely successful. A breakthrough shall be made by a process consisting of simultaneous mechanical graining combined with a high selective leaching. Zinc and lead recovery shall be better than 98% and because the leaching process shall be highly selective, the zinc oxide produced is uncontaminated with iron from the raw dust, and is thus more valuable to the zinc manufacturers."