RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Host-virus chemical arms race during algal bloom in the ocean at a single cell resolution' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Phytoplankton blooms are ephemeral events of exceptionally high primary productivity that regulate the flux of carbon across marine food webs. The cosmopolitan coccolithophore Emiliania huxleyi (Haptophyta) is a unicellular eukaryotic alga responsible for the largest oceanic algal blooms covering thousands of square kilometers. These annual blooms are frequently terminated by a specific large dsDNA E. huxleyi virus (EhV). Despite the huge ecological importance of host-virus interactions, the ability to assess their ecological impact is limited to current approaches, which focus mainly on quantification of viral abundance and diversity. On the molecular basis, a major challenge in the current understanding of host-virus interactions in the marine environment is the ability to decode the wealth of “omics” data and translate it into cellular mechanisms that mediate host susceptibility and resistance to viral infection. In the current proposal we intend to provide novel functional insights into molecular mechanisms that regulate host-virus interactions at the single-cell level by unravelling phenotypic heterogeneity within infected populations. By using physiological markers and single-cell transcriptomics, we propose to discern between host subpopulations and define their different “metabolic states”, in order to map them into different modes of susceptibility and resistance. By using advanced metabolomic approaches, we also aim to define the infochemical microenvironment generated during viral infection and examine how it can shape host phenotypic plasticity. Mapping the transcriptomic and metabolic footprints of viral infection will provide a meaningful tool to assess the dynamics of active viral infection during natural E. huxleyi blooms. Our novel approaches will pave
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Child-friendly justice for the climate crisis: Post-paternalist judgments, litigation, participation' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

YOUTHCLIMATEJUSTICE is the first large-scale transnational examination of youth justice in the climate crisis. In climate activism/litigation, under-18s are often leading on a political issue on a global scale – this is unprecedented in human rights law. Yet most children’s rights literature examines children as victims in the climate crisis. We know from other areas of law (e.g. family, criminal etc.) that justice processes are ill-suited to children, and have to be tailored to their needs. A body of work on ‘child-friendly justice’ has arisen to deal with this. YOUTHCLIMATEJUSTICE examines how child-friendly justice, and consequently children’s rights scholarship, is transformed by youth climate activism. The project proposes the ‘post-paternalism’ hypothesis – traditionally it is assumed that children are ‘given’ rights by adults such as the right to be heard, but youth climate activists are taking control of their own rights, e.g. in justice systems. YOUTHCLIMATEJUSTICE aims to work beyond contemporary paternalistic approaches to the UN Convention on the Rights of the Child; examining intergenerational dynamics in this ‘post-paternalist’ climate context. This will be done through three work packages examining youth climate justice in: 1.judgments 2.litigation and 3.participation. This transdisciplinary project will include innovative methodology including IDEAL causal modelling of case law data; surveys; and participatory action research (in Barbados, Canada, Ireland, Nepal, and South Africa) to theorise transformation in children’s rights through youth climate action. It is a groundbreaking democratic endeavour whereby children can shape both academia and human rights for a post-paternalist world. Outputs include a new evidence-informed framework on Child-Friendly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Exploiting GLIOblastoma intractability to address European research TRAINing needs in translational brain tumour research, cancer systems medicine and integrative multi-omics'.

assistant: **Innovation**

Glioblastoma (GBM) is the most frequent, aggressive and lethal of all brain tumours. It has a universally fatal prognosis with 85% of patients dying within two years. New treatment options and effective precision medicine therapies are urgently required. This can only be achieved by focused multi-sectoral industry-academia collaborations in newly emerging, innovative research disciplines. GLIOTRAIN will exploit the intractability of GBM to address European applied biomedical research training needs. The ETN, which comprises 9 beneficiaries and 14 partner organisations from 8 countries, will train 15 innovative, creative and entrepreneurial ESRs. The research objective of GLIOTRAIN is to identify novel therapeutic strategies for application in GBM, while implementing state of the art next generation sequencing, systems medicine and integrative multi-omics to unravel disease resistance mechanisms. Research activities incorporate applied systems medicine, integrative multi-omics leveraging state of the art platform technologies, and translational cancer biology implementing the latest clinically relevant models. The consortium brings together leading European and international academics, clinicians, private sector and not-for-profit partners across GBM fields of tumour biology, multi-omics, drug development, clinical research, bioinformatics, computational modelling and systems biology. Thus, GLIOTRAIN will address currently unmet translational research and clinical needs in the GBM field by interrogating innovative therapeutic strategies and improving the mechanistic understanding of disease resistance. The GLIOTRAIN ETN addresses current needs in academia and the private sector for researchers that have been trained in an environment that spans translational research, me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Modular Design of Bacterial Lipid Mimics for Next-Generation Antimicrobials'.

assistant: **Objectives**

Antimicrobial resistance in bacteria is a growing public health crisis, as common drugs are becoming ineffective against many species of pathogenic bacteria. This research aims to devise highly specific and stable antimicrobials, which target the amphiphilic component that anchors LPS to Gram-negative bacterial membranes, “Lipid A”, for direct antimicrobial effect and to potentiate other antimicrobials.  Taking inspiration from bacterial lipids, which possess multiple tails and a polybasic headgroup, synthetic cationic lipidoids have the potential to be highly specific bacterial membrane-targeting antimicrobials. Preliminary results demonstrate that some cationic lipidoids bind and disrupt bacterial lipid assemblies, and significantly inhibit the growth of E. coli at micromolar concentrations.  However, the breadth of potential molecular structures arising from the range of available starting materials makes the search for optimum compounds an insurmountable task. This proposal outlines an innovative use of statistical software to steer modular synthetic design and expedite the identification of promising new antimicrobials. Relative to a ""one-factor-at-a-time"" approach, statistical design can quickly uncover correlations between structure and activity, and unexpected interactions between structural variables, thus accelerating the discovery of antimicrobial compounds that would not otherwise be obvious. In addition to uncovering new compounds selective to bacteria, libraries of lipidoids will be investigated to help uncover design rules for the effect of shape on membrane interactions, and generic mechanisms of membrane-targeting antimicrobial action. Results could also lead to new means to potentiate obsolete antimicrobials that are impermeable to bacterial membrane
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Bioactive coating to prevent catheter infection and thrombosis'.

assistant: **Concept**

Peripheral and central venous catheters are among the most implanted blood-contacting medical devices for short and long-term clinical applications, respectively. Despite implementations of in-hospital measures, catheters are often subject to infection and thrombotic complications, which result in longer hospitalization stay, higher health care costs, or even death.   The CMD-COAT project aims at providing an innovative and rapid solution to this major medical, economical and societal need.  The solution comes from our patented technology, referred to as Coatigel, that consists of grafting multilayer cross-linked nanogels with combined antifouling, antimicrobial and antithrombotic properties onto catheter surface. The combination of these properties can guarantee longer catheter clinical performance than any currently available products.    Our project includes all the validation steps that will enable us to bring Coatigel on the catheter market. We will assess Coatigel compliance with ISO standards and compile the technical file for CE mark application in accordance with EU directives for class III medical devices. The whole process will be realized under the guidance of a company specialized in quality management to ensure optimal reliability and efficacy. The project also involves setting up partnerships with catheter industries to adjust our technology to manufacturing constraints. Via services of marketing experts, we will take on a competitive market analysis, including geographic segmentation, to position Coatigel in the catheter market. This project will result in the creation of a coating spin-off company with the exclusive right of Coatigel commercial exploitation. The presence of several big catheter manufacturers in Belgium is a main asset for our business s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'UnderstandiNg fraIlty tOwards a future of healthy ageiNg' under Horizon Europe.

assistant: **Concept**

With falling birth rates and increasing life expectancy we are an ageing society. 20% of boys and 25% of girls born in 2019 are expected to reach their 100th birthday. This would be good news if it were not for the fact that healthy life span has not kept pace with increasing longevity and now on average adults spend the last 15-20 years of life in ill health.  Frailty is a major component of ill health in old age and refers to an enhanced vulnerability to stressors, such as falls, surgery or infections, which was demonstrated clearly in the mortality data for the COVID19 pandemic. The transition from robust health to frailty is a critical factor in the loss of independence and places increased pressure on health and social care. All of this has led governments to prioritise the enhancement of healthspan.The Doctorate Network on UnderstandiNg fraIlty tOwards a future of healthy ageiNg (UNION) is a multi-partner joint doctoral research training network with the overall aims of educating 13 Early Stage Researchers (DCs), advancing the current understanding of frailty, and providing innovative solutions on how healthy ageing can be achieved. UNION brings together world leaders in a range of relevant disciplines (frailty, ageing biology and ageing medicine, inflammation, immunosenescence, immunometabolism, stem cell biology) with state-of-the art technologies including mass spectrometry metabolomics, advanced imaging, artificial intelligence, CRISPR-CAS9 libraries, SPECTRA 35-colour flow cytometry, global and conditional knockout mice. This technological excellence is applied to the clinical situation through unique longitudinal human ageing and frailty cohorts, longitudinal assessment of age-related multimorbidity in animal models and innovative multidimensional frailty in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Future Fashion Design\nReal-time, Accurate Fabric to Garment Virtual Prototyping in \nCollaborative Environments' (FFD).

assistant: **Innovation**

The FFD project (targeting the Objective FoF-ICT-20111.7.4, focusing on target 7.4b and partly addressing 7.4c) aims to remove the main factors inhibiting the wide adoption of Virtual Prototyping  (VP) by the Textile and Clothing companies (TCI), by drastically improving the speed of obtaining  realistic garment simulations (development of massively parallel simulation techniques based on multi-core computing), the  accuracy   (simulation from yarn - to fabric - to garment, virtual garment close to real sample)  and the functional integration aspects (Collaborative Prototyping  offered as a SaaS  platform). The new business model will offer drastic improvements in product development efficiency (reduced number of physical samples from 20% to 100%, time-to-market reduced by 3 weeks, collaboration between fabric and garment producers), services at low-cost (open, vendor independent and scalable platform), while opening new market opportunities to vendors of CAD and PDM/PLM systems. A just-right Consortium of 6  organisations: A leading European Institute (Fraunhofer-IGD) as Coordinator (will develop the massively parallel simulation engine), Assyst (apparel CAD) and ScotCad (fabric CAD) already offering state-of-the-art 3D VP solutions will work on improving simulation accuracy (from yarn to garment), ATC an ICT company with expertise in web integration based on the SOA model will develop a Collaborative Design and Prototyping  platform (CDP),  and two end-users (Piacenza- manufacturer of fine woollen fabrics and Consitex, the garment manufacturing member of the Ermenegildo Zegna Group) will integrate the innovative VP platform in their joint product development processes and will demonstrate/ evaluate its efficiency and impact. Various exploitation schemes will be adopte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Common Highways Agency Rijkswaterstaat Model', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Over the past four years, Rijkswaterstaat, the Highways Agency and the Roads and Traffic Agency  have worked together to share knowledge and approaches to solving common problems. This relationship is embedded in a joint Memorandum of Agreement.The organisations are very similar and share many of the same problems and challenges in managing their Strategic Road Network (SRN). Each organisation faces issues in addressing rising cost of ownership of traffic management systems due to end-of-life traffic technology systems which have strong vendor lock-in.  Neither organisation can solve its problems by purchasing existing commercial off-the-shelf (COTS) solutions in the traffic technology market because the traffic technology market has been slow to adopt a COTS approach. It is only via aggregated demand of the leading SRN operators that the market can be expanded and costs reduced. Both organisations wish to decouple the technology solutions from the business requirements so that the business is free to implement new operating models and realise significant efficiency savings.Without embarking on this programme, the HA will experience accelerated technology maintenance costs, reduced reliability, an inability to cost effectively meet the demands of Traffic Management Directorate (TMD) arising from the implementation of the Future Operating Model (FOM), and jeopardise TMD's programme of efficiency savings. Without this programme RWS will experience a lack of business flexibility.The CHARM programme has two primary objectives:<br/>\tTo establish and validate a Pre-Commercial Procurement (PCP) process in the participating countries\tTo use that process to identify new technologies and services to address the challenge of providing a Traffic Management System.<br/>By the co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ecological significance of uncultured marine stramenopiles' (ESUMAST), addressing dissemination and exploitation.

assistant: **Impact**

This project addresses the key issue of the relationship between diversity and ecological function in the uncultured heterotrophic eukaryotic microbes dominant in marine planktonic food webs. On one hand, heterotrophic flagellates is a functional group wit h accepted central roles in marine ecosystems (grazing on picoplankton, nutrient remineralization) and studies so far have treated them as a black box, formed mostly by small and unidentified cells.On the other hand, several recent molecular studies based on environmental rDNA sequences have revealed the existence of unknown eukaryotic microorganisms. A significant number of these sequences were found to be affiliated to the stramenopile taxon, a very heterogeneous assemblage of protists, but were not similar to any known group. Those were named MAST (Marine Stramenopiles), and some of them are heterotrophic and bacterivorous flagellates.Even though scientists start to have an idea of the distribution and phylogenetic relationships within these MAST groups, their role and significance in marine microbial food webs remains largely unknown. In the proposed research project, we will use a combination of innovative methodologies within a multi-disciplinary oceanographic context to open the heterotrophic flagellates' black box and investigate the ways MAST organisms interact with the other components of the natural microbial assemblage, particularly with photosynthetic picoplankton, which are major primary producers in the oceans.The host research team is one of the most experienced European teams in that field and the structured training program is designed to provide broad experience in the application of cutting-edge techniques to investigate major cross disciplinary issues in modern microbial ecology and oceanography.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Innovative e-environment for Research on Cities and the Media'.

assistant: **Objectives**

I-Media-Cities is the initiative of 9 European Film Libraries, 5 research institutions, 2 technological providers and a specialist of digital business models to share access to and valorise audiovisual (AV) content from their collections for research purposes in a wide range of social sciences (sociology, anthropology, urban planning, etc). The project revolves around cities in European history and identity. A huge quantity of fictional and non-fictional AV works (from the end of the 19th century onwards) in their collections describe cities in all aspects, including physical transformation and social dynamics. Such material could prove of enormous value to scholars in different fields of study. I-Media-Cities plans integration and technical development work to push interoperability among 9 archives and generate two types of e-environments to be used by researchers and innovators for research and other creative purposes. This will allow new approaches to research in social sciences and unleash creativity, in new forms of delivery and consumption of that content which the creative industry would be able to propose for instance in tourism or in the cultural economy. To make that possible, the project relies on collaboration among three main components: a) FHI (Film Holding Institutions); b) research institutions in different areas of social sciences; c) expertise in exploitation processes of digital content. At the end of the project, we will deliver a digital content access platform (interoperable and multilingual), made available to a growing community of researchers and creatives Europe-wide to push the boundaries of what we can learn, through AV material on cities, on European history and identity. The legacy of I-Media-Cities will be a new model for research on digit