RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A minimal Cys-cyclobutene non-canonical amino acid for bioorthogonal imaging of proteins in live cells' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Insight into dynamic processes such as uptake and intracellular trafficking and signalling of small molecules and proteins in cells is key in basic biology and drug development. The use of bioorthogonal chemical reactions for labelling and probing specific biomolecules is an exciting option but a very challenging task as these transformations should proceed very rapidly in physiological conditions with complete chemoselectivity. So, in this application we propose to achieve site-selective protein labelling by the introduction of a non-canonical Cys-cyclobutene aminoacid and a very fast alkene chemoselective ligation reaction. The small size of the proposed alkene-tagged aminoacid should not interfere with the protein structure, function, activity or localisation in contrast with other fluorescent tags such as the use of fusion proteins as GFP. This project aims at 1) developing  a new photo triggered [2+2] cycloaddition bioorthogonal ligation between two alkene containing partners and to apply the already established IEDDA reaction between tetrazines and dienophiles. While the use of light as a trigger offers the possibility for an improved spatial and temporal resolution,  the use of tetrazine fluorogenic probes allows for ‘turn-on’ fluorescence on their rapid reaction with dienophiles 2) use these optimized reaction to study apoptosis in cells and tissues by introducing the proposed Cys-cyclobutene non-canonical amino acid into C2A Domain of Synaptotagmin-I followed by the ligation reaction ex vivo and in vivo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'USF transcription factors as crucial skin-stress-mediators', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The skin is the first body defence towards various injuries including UV-rays. The molecular mechanism underlying the UV-response is in part dependant on gene expression modulation implicating the ubiquitous family of USF transcription factors. They have been largely involved as critical UV-activators of genes expression in melanocytes, mediating the UV-induced tanning-response following activation of the stress-responsive p38 kinase. Mitf, the master melanocyte regulator, mediating melanocyte stem cells and melanoma proliferation/differentiation is also a member of the b-HLH-LZ family and is a downstream target of the p38 kinase. How do these transcription factors cooperate to influence skin protection and melanoma progression remains an opened question? The specific aims of the project will be focused on the less documented member the USF-family and are as follow: 1. To determine the role of USF1 at skin level, after UV induction (USF1 KO mice model). 2. To identify the target genes of USF factors at a high level (ChipChip). 3. To correlate USF activity with stress mediated transcriptional regulation and protein modifications. We anticipate that the results will reveal both general principles on USF-target genes and function after UV or environmental stress and also general molecular process implicated in skin-protection and melanoma formation that are regulated at the transcriptional level. The proposal addresses important issues by the use of physiological model in order to identify key pathways for metabolism with long term implications for skin protection and melanoma treatment. The project provides high quality technical and intellectual inputs on the basis of close collaboration and technology transfer with scientific and medical laboratories in France. The proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Coherent Elastic Neutrino Nucleus Scattering and Dark Matter with Spherical Proportional Counters' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

neutrinoSPHERE, following a multidisciplinary synergic approach, will comprehensively investigate the wider aspects of astroparticle physics. It will exploit the potential of Spherical Proportional Counters (SPC) developed by NEWS-G Collaboration and will develop novel tools based on Machine-Learning (ML) techniques to conclusively respond to long-standing puzzles in particle physics such as the nature of neutrinos and the existence of dark matter (DM). The ultra low-threshold capabilities of SPCs are ideal to explore neutrino magnetic moments through coherent elastic neutrino-nucleus scattering (CEvNS), and sub-GeV boosted-DM signatures induced by: cosmic rays, Diffuse Supernova Neutrino Background and solar reflection. Furthermore, neutrinoSPHERE will open new directions expanding the scientific programme and physics reach of NEWS-G to additional components of the dark sector via the dark boson portal: dark photons, dark scalars, and axion-like particles. To address these challenges, neutrinoSPHERE will develop NEWS-ML, a novel simulation framework based on ML, offering rapid and fully validated state-of-the-art simulations of CEvNS, DM and hidden sector signals in SPCs. The performance of NEWS-ML will be accelerated with GPU technology and MPI-parallelisation, facilitating statistical inference and accurate constraints extraction. neutrinoSPHERE offers the ideal template to achieve the required breakthroughs in astroparticle physics by investigating previously-unexplored regions of BSM scenarios, in which existing rare-event searches have limited sensitivity, thus complementing them. The research team has diverse expertise, ranging from instrumentation and detector R&D to beyond the Standard Model phenomenology. The scientific results will be disseminated in differen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Distributed Human-Robot System for Chemical Incident Management' (DHRS-CIM).

assistant: **Innovation**

The overall objective of this project is to combine forces of Europe’s leading industrial (Thales Nederland B.V., Space Application Services N.V., IdMind - Engenharia de Sistemas Lda) and academic organizations (Universities of Sheffield, Amsterdam and Örebro) in the field of ‘Disaster Management’, in order to deliver, through a strategic and intersectoral exchange of researchers, an intelligent decision support system for humans to manage chemical incidents (a Distributed Human-Robot System for Chemical Incident Management or DHRS-CIM).   The proposed research deals with human and artificial sensing and sense-making to support human decision making in crisis management. The focus on both artificial- and human-system research in order to integrate both is one of the essential contributions of this research proposal: by doing so the artificial systems and humans together become an intelligent collaborative system. This is highly relevant for Europe as future deployment of such intelligent systems able to detect (potential) chemical incidents, helps crisis professionals take informed decisions to manage chemical incidents.  Intersectoral exchange of knowledge will not only lead to (short term) development of innovative technological breakthroughs within this domain, but will also ensure the development of participating researchers towards interdisciplinary scientists needed for research in this (timely) relevant field.   Various types of transfer of knowledge are envisioned, such as numerous visits resulting in joint research projects, integration sessions and meetings (e.g. yearly summer schools).  Furthermore, structuring effects at the European level are expected by a more structural and strategic future collaboration between the project partners. Finally, the project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Securing the European Electricity Supply Against Malicious and accidental thrEats' (SESAME), addressing dissemination and exploitation.

assistant: **Impact**

Threats for the supply of electricity have changed dramatically throughout the last decade: additional to the natural and accidental ones, the new threat of malicious attacks needs to be considered. Such attacks might be jointly imparted so as to affect large portions of the European grid, make repair difficult and cause huge societal impact. The outstanding importance and the far more complex level of interconnectivity of electricity distribution / transmission / generation – compared to the supply through other energy carriers - makes the development of a highly focused toolkit for its protection an essential and urgent task. SESAME develops a Decision Support System (DSS) for the protection of the European power system and applies it to two regional electricity grids, Austria and Romania. This DSS enables to:• identify the vulnerabilities and to detect their origins,• estimate the damage / impact of real or simulated network failures,• identify the possible measures for prevention of outages and acceleration of automatic restoration,• rank these measures according to their effectiveness and their cost-benefit ratios,• carry out contingency analyses of the transmission / distribution network and generation facilities,• detect long-term erroneous trends in the security of energy supply and counteract against them by adjusting the market mechanisms.There do not exist State-of-the-Art approaches incorporating all of these core dimensions of the problem: the increase in complexity of the security of energy supply requires a comprehensive and multi-disciplinary solution. SESAME brings together the most distinguished experts in the fields of power network security, technology policy and regulatory economics, impact assessment of disasters, network simulation software and kn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European early warning system for systemic risk.' in the context of a Horizon 2020 call.

assistant: **Objectives**

EARLINESS.eu proposes a new European early warning system (EWS), able to identify and signal economic vulnerabilities in order to allow policy makers to intervene in a timely manner. The ongoing European financial crisis poses a serious challenge to the stability of the euro area and growth prospects in Europe. The aim of the EARLINESS.eu project is to implement a EWS for systemic risk to prevent and mitigate financial instability by exploiting the linkages among the financial markets and the real economy. Given the potentially high and unsustainable costs caused by systemic crises, it is of fundamental importance to establish a comprehensive system of early warning signals and indicators to monitor them. Recent studies suggest that empirical analysis should focus on the macroeconomic and financial shocks transmission across countries, allowing for nonlinear propagation of these shocks. The innovative purpose of EARLINESS is to fill this gap by modelling nonlinear interactions between the financial market and the macroeconomic system. The main challenge is the realization of a comprehensive system able to detect and measure each marginal change in the sources of systemic risk by developing an innovative building block structure. A novel Dynamic Quantile Factors model is introduced to extract the latent signal of systemic risks at micro and macro level from a panel of institutions belonging to the European area and partner countries. The project uses state-of-the-art systemic risk measures and integrates new methodologies in financial econometrics, systemic risk measurement and big data analysis tools. According to the Macroprudential Research Network of the ECB, the implementation of macroprudential policy is still at an early stage and much effort is needed to support
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Partnerships for Sustainable Shrimp Aquaculture' (PASSA).

assistant: **Innovation**

Aquaculture effluents represent a main environmental concern because of their high polluting potential. While fish farms of advanced countries adopt a medium/high-tech approach to this issue, less industrialised countries rely on low-tech systems, if any. Shrimp culture is an important economic sector in which Asian countries are the main producers/exporters and industrialised countries are the main importers/consumers. Asian aquaculture makes up almost 80% of world shrimp (P. monodon and P. vannamei) production. As most of the shrimp farms have serious negative impacts on environment caused by waste effluents containing pollutants, one of the main needs of Asian shrimp culture is the implementation of advanced effluent management systems which can burst the rearing efficiency up to manifold increase of production, reducing the environmental impact. On the other hand, EU aquaculture, which possesses a large know-how on intensive fish farming, lacks of intensive shrimp culture because the only species reared (P. japonicus) can be grown only in extensive plants. The present project envisages a complementary cross-exchange of their know-how and competencies in the field of shrimp culture between EU and Indian researchers. Respective aims are: (i) the implementation of cost-effective systems for the treatment of shrimp farm effluent to reduce the environmental impact of  Indian commercial aquaculture; (ii) the implementation of closed systems for the reproduction and growth of new shrimp species (P. monodon and P. vannamei) suitable for intensive rearing in EU aquaculture. Available systems and applicable technology will be considered for application and their efficiency to prevent recipient ecosystem pollution will be verified and monitored through analytic characterisatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'p-wave superfluidity and BCS-BEC crossover of ultracold polar molecules' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

P-wave superfluids of fermionic particles are a crucial subject of study in condensed matter systems, where fermions pair up with nonzero angular momentum and exotic quantum phenomena like Majorana zero mode are predicted to exist. Investigation into the p-wave superfluids not only helps unravel the underlying mechanism of high-T superconductors but also provides insights into the fundamental symmetry of elementary particles. Over the last decade, ultracold quantum gas of polar molecules with controllable long-range dipolar interaction has emerged to be a powerful testbed to investigate such exotic quantum phases. At sufficiently low temperatures, fermionic molecules can pair up with p-wave symmetry and form a many-body BCS state. With the molecular scattering controlled with field-link resonances, the BCS-BEC crossover of diatomic molecules can be achieved. However, cooling of these fermionic molecules to this regime and the detection of their emerging properties remains challenging. The main goal of MolPWSupFluid project is to cool polar fermionic NaK molecules to unprecedentedly low temperatures and study the many-body behavior with strong dipolar interaction including p-wave superfluidity and their crossover to a Bose-Einstein condensate of tetratomic molecules. This project will focus on technical advancements in microwave field control, enabling state-of-the-art evaporative cooling of dipolar molecules and facilitating the precise manipulation of molecular scattering with microwave-induced field-link resonances. With successful cooling of the NaK molecules below the superfluid critical temperature, we will investigate the anisotropic pairing property and the Higgs mode excitation of the molecules with critical velocity and Bragg spectroscopy. Finally, we will inve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Awareness and training for the ncp-poland network', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The objective of POLNET is to raise awareness and provide training for more than 100 members of newly established network of 24 Regional/ Thematic Contact Points (trainers) as well as representatives of universities, research institutes and SMEs referred to as Local Contact Points (multiplications). German, Austrian and Polish experts will carry out three training courses in northern, central and southern Poland. The manual (lecture notes) and the trouble shooting guide will be prepared.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Entropy for Quantum Information Science' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Entropy for quantum systems is the fundamental, interdisciplinary concept to quantify the advantage of quantum technologies for processing of information. It is well-established that the quantum advantage originates from the strong correlations found in the entanglement spectrum of multipartite quantum states, as exactly characterised by the information-theoretic tool quantum entropy. Contrary to the case of classical systems, however, our knowledge about the mathematics of quantum entropy is much more limited. Nonetheless, special entropy inequalities that are known to hold in the quantum case, such as the strong sub-additivity of quantum entropy, give crucial insights into the entanglement structure of multipartite quantum states. In this project, I will focus on understanding multipartite entropic constraints, which will lead to tight characterisations of the ultimate, physical limits of quantum information processing.My recent mathematical works in quantum information led to operational extensions of the concept of strong sub-additivity from the seventies. Starting from that, I propose a research program that will lead to an understanding of quantum entropy that is on the same level as for the classical, commutative case. In the first part of my project, I will establish techniques in matrix analysis and optimisation theory to understand the interplay of arbitrarily many non-commuting operators. This mathematical framework will allow to prove novel quantum entropy inequalities that lead to refined approximations on the entanglement structure of multipartite quantum states. Second, I will employ the newly obtained entropic constraints to derive approximation algorithms for a plethora of fundamental problems in quantum information science. This includes schemes for ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'ExplorinG by in situ and operando techniques the native dEgradation MechanIsms and longe range propagatioN In metal halide perovskite'.

assistant: **Innovation**

GEMINI aims to advance fundamental understanding about the halide perovskite structure dynamic subsequently to photons absorption and how the latter can seed the early stage degradation. The state-of-the-art overflows of comparative ex situ analysis before and after ageing. This approach does reveal neither information on early stage degradation nor relevant information on their propagation. GEMINI has the ambition to fill in this understanding gap through a holistic approach to cover the multiscale degradation facets. For this, specific developments are integrated, in particular a table-top time-resolved X-ray scattering diffractometer to explore ultrafast structural dynamic in lab. GEMINI addresses all drawbacks of ex situ analysis and the constrains of the perovskite sensitiveness to high probe dose or high vacuum which itself contribute to the degradation. GEMINI will reveal live information resulting exclusively from in situ and operando approaches based on low-dose techniques, through specifically developed sample chambers and setup modifications. Ultrafast time-resolved and electron spin resonance spectroscopies, time-resolved and steady-state X-ray diffraction and live-scanning environmental transmission electron microscopy (STEM) combined to the latest development in 4D-STEM/ASTAR are combined to gather comprehensive multiscale information about degradation upon all relevant ISOS stressors, one at once and in combination to assess the synergetic effects. GEMINI is built upon solid background competences with these advanced techniques to ensure impacts beyond the state-of-the art (SoA): (i) understanding perovskite structural dynamic and relaxation upon photo-excitation down to 1ps time scale, (ii) revealing the multiscale degradation pathways from seeds to long