RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A new approach to gene therapy: development of a model for application of therapeutic proteins against human Philadelphia positive leukaemias' in the context of a Fourth Framework call.

assistant: **Objectives**

A key obstacle in the effective treatment of patients with cancer is to distinguish between tumour cells and normal cells, and this represents the major limitation for most of the current treatments. Through the de novo design of zinc finger proteins which can bind to any specific DNA sequences this distinction can be made by designing these to bind specifically to the genetic modifications which can be defined at the DNA sequence level in some cancers. This was recently demonstrated by developing a zinc finger protein which specifically recognized the unique DNA sequence at the breakpoints junction of the chromosomal translocation which creates the BCR-ABLp190 oncogene. The DNA binding of these proteins was shown to be effective in repressing transcription in vivo resulting in apopotosis of the cells. To realistically conceive of using this approach in patients we need first to be able to test its efficacy in an animal model system which recapitulates the DNA rearrangement events resulting in oncogene activation. We therefore plan to generate in the mouse the equivalent DNA rearrangement found in the human acute lymphoblastic leukaemia associated with the Philadelphia chromosome, which involves fusion of the BCR and c-ABL genes by translocation. To model this abnormality in-vivo we will develop a binary transgenic system to allow activation of a site-specific DNA recombination event that will be restricted to the lymphoid lineage. In this scheme, gene targeting in ES cells will be used to construct murine bcr and c-abl sequences containing loxP sites, which are short sequences which can be cut and rejoined by a recombinase Cre. The precise arrangement of the bcr and c-abl sequences will be such that in mice derived from these ES cells these will be in a non-functional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Imaging Mass Spectrometry of Fungal – Bacterial Interplay'.

assistant: **Objectives**

FUNBIT aims to enhance the discovery rate of natural products applying a multidisciplinary workflow guided by Imaging MS.Microbial genetics predict that the natural products we have discovered so far are only the tip of the iceberg, thus we may be missing the antibiotics and biopesticides of the future. In fact, many natural compounds remain invisible under standard laboratory conditions, but their biosynthesis can be triggered by re-establishing the structure of their native community in multi-microbial co-cultures. Thus, hidden natural products that enable microbes to communicate and compete with each other can be revealed. However, microbial interkingdom partnerships such as fungi-bacterial microbial interactions are still in general poorly explored. The detection of cryptic natural products from microorganisms is a major challenge because many of them are produced in small quantities, in a specific area and during a short period of time. The emerging technology of Imaging Mass Spectrometry can be the best candidate to investigate multi-partner microbial interactions in their native ecological environment, and find the natural products involved in their cross-talk. FUNBIT aims to speed up the rate of natural product discovery (especially polyketides, and lipopeptides, since many antibiotics fall into these groups) by integrating Imaging MS with High Resolution MS, spatial statistics and molecular network analysis. We will focus on fungi-bacterial partnerships involved in important agricultural infections, such as root diseases. These microorganisms are safer to handle, but the discovered antibiotics and antifungals will potentially target human pathogens. FUNBIT will be supervised by Prof. Christian Hertweck, who was awarded in 2015 with the Gottfried Wilhelm Leibniz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Flexible Optical Cross-connect Nodes enabling next generation flexible optical networking' in the context of a Seventh Framework call.

assistant: **Objectives**

Flexible optical networking is widely proposed today by major vendors and operators as the solution that offers smooth system upgradability towards Tb/s capacities and optimized use of network resources. Latest research and development efforts proposed a variety of multi-carrier signal transmission methods with significantly increased spectral efficiency, (compared to legacy WDM), allowing the transport of ultra-high capacity channels and the adaptive filling of wavelength channels according to the demands and the required performance on a link distance basis. These developments enable the flexible bandwidth utilization of the optical links but are limited to the point-to-point transport of data. The key network element required to truly enable the realization of a flexible optical networking system is a flexible switching node capable to adaptively add, drop and switch tributaries with variable bandwidth characteristics from/to ultra-high capacity wavelength channels at the lowest switching granularity.<br/>The FOX-C project aims to design, develop and evaluate the first functional system prototype of flexible add-drop multiplexers and flexible optical cross-connects, with fine switching granularity at the optical subcarrier level with the purpose to enable the end-to-end network routing of any tributary channel with flexible bandwidth down to 10Gb/s carried over wavelength superchannels, each with an aggregated capacity beyond 1Tb/s. Moreover, the project will define and evaluate the flexible transmission solutions and their exact characteristics, thus providing a holistic flexible optical networking approach applicable in next generation networks.<br/>The FOX-C project consortium consists of industrial partners with leading position in the field of optical node desig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'FARMING AND RURAL INFORMATION, EXPERTISE AND DISSEMINATION SERVICE'.

assistant: **Concept**

FRIENDS seeks to test prototype electronic information networks for better organisation of locally-based rural agricultural associations and cooperatives in Europe, and improved communication between them. Such networks are seen as the key to linking isolated bodies to information sources, as well as to a geographically extended base for provision of expertise and training. The project will address the technology to be adopted, the suitability of information sources vis-à-vis user needs, and the support of both by the organisational structures. Economy as well as user acceptance and speed of take-up will be among the aspects monitored.Electronic information networks will have important ramifications on how rural agricultural community associations and co-operatives communicate with each other and, on a more fundamental level , how they are organised.These networks are the basis for linking isolated organisations to various information sources, and perhaps more importantly to a geographically extended expertise and training base. Furthermore, the same network will also serve to link these isolated organisations to each other. In designing solutions for this environment three fundamental issues need to be addressed in parallel: the actual technology to be utilised, the agricultural information source as related to users needs, and the support of the technology and the information sources by the organisational fabric. We propose to use a combination of fast-prototyping and scenario building which will be used to envisage and explore with the end-users the different possibilities and shortcomings of the proposed technology.The pilot system will be composed of 6 main rural end-user" sites , and several other "expert/information" sites. The trial will be monitored to evaluate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Femtosecond Raman Spectroscopy: ultrafast transformations in physics, chemistry and biology'.

assistant: **Objectives**

We propose the construction and development of a femtosecond broadband stimulated Raman setup to tackle ultra fast chemical, physical and biological processes taking advantage of the top-notch structural sensitivity inherent to the Raman process. The use of a pump-probe stimulated scheme will allow to overcome time-energy restrictions dictated by the uncertainty principle, enabling to reach the femtosecond timescale with energy resolutions which would pertain to the picosecond time domain in the Heisenberg sense. Protein dynamics span several orders of magnitude extending up to macroscopic timescales, the recipes to tailor properties of rubbers and polymers relevant for human timescales are covered by more than 500000 patents, rust reaction occurs over several days, and lethal brain strokes often lead to death within 24 hours on average. The lowest hierarchical level of such processes, however, is hidden in the very act of atomic motion and chemical binding such as the single bond dynamics in a peptide backbone, the monomer cross-linking elemental reactions, the energy flow and re-distribution in a hydrogen bond network, or the oxygen binding to heme proteins, all performing on the femtosecond stage. Mastering these processes is the essence of femtochemistry, born around the backbone of the femtosecond laser technology and boosted by scientific activity which led to the Nobel prize of Prof. A. Zewail in 1999. The new capabilities offered by femtosecond sources have often left behind in the race traditional spectroscopies, which hardly follow the growing emergence of new challenging problems in which the traditional distinction between biology, chemistry and physics is smeared out by the common ultra short timescale. The set up of a non conventional femtosecond Raman tec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Per. design', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The topic of the project is the proposal of a scientific international symposium of academic level on the reflection about the nature, models and cultures of research as taking shape within the boundaries of the disciplines of design, ranging from product to visual or communication design.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Loss of freezing tolerance under warm conditions and low temperature memory in the closely related species Arabidopsis thaliana and Thellungiella salsuginea – metabolomic and transcriptomic approaches'.

assistant: **Objectives**

Cold limits the geographical distribution, yield and growth season of both native vegetation and crops. Temperate perennials show an increase in freezing tolerance under low temperatures. This cold acclimation process involves massive changes in gene expression and metabolite contents. Plants lose freezing tolerance after transfer back to warm temperatures by de-acclimation. While cold acclimation has been studied extensively, de-acclimation and the persistence of the acclimated state under warm conditions (memory phase) have not attracted much attention. Therefore, the physiological and molecular mechanisms that determine the extent of this memory under a given condition remain to be identified. Also, how such a memory phase may influence a subsequent low temperature response has only rarely been investigated on the phenotypic level (i.e. as increased freezing tolerance termed ‘re-acclimation’) and not at all on the molecular level. In this project we aim to: (1) physiologically and biochemically characterize the cold acclimation, memory and re-acclimation responses in natural accessions of Arabidopsis thaliana and its close relative Thellungiella salsuginea. (2) Investigate the metabolic reprogramming as a result of the treatments using GC-ToF-MS metabolite profiling and (3) unravel the transcriptional and post-transcriptional responses of the plants to these treatments using microarray hybridization on total mRNA as well as qRT-PCR on total mRNA and mRNA derived from polysomes. Objective 4 is to identify preferentially regulated functional classes of genes and identify metabolic pathways of particular importance during the different temperature responses in the two species using various bioinformatic approaches. The results will increase our understanding of regulati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Melt-made polymer nanocomposites  melt-nanocomp""'.

assistant: **Innovation**

Nanocomposites exhibit unique combinations of properties e.g. improved mechanical and surface properties, lower densities as compared with conventional reinforced plastics, and halogen-free flame retardancy. However, nanocomposites manufacture requires the use of expensive nanofillers.This RTD project aims at decreasing the costs:i) by avoiding expensive wet-chemistry steps and;ii) by reducing the number of processing steps. A first main innovation is the combination of high-shear compounding and reactive processing techniques to produce concentrates. A second originality is the combination of high-shear and in-line processing technologies, enabling shaping of pieces in one compounding/processing step. Technology demonstrators for the automotive, electrical and mechanical moulded goods will be produced.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A European Training Network for Sustainable Phosphorus Chemistry' to be submitted under Seventh Framework.

assistant: **Abstract**

The SusPhos training network will bring about a paradigm shift in the teaching of sustainable phosphorus chemistry, in the training of multidisciplinary-competent scientists, and in the public’s view on chemistry to preserve the essential element phosphorus from depletion. SusPhos represents the first systematic investigation of the eco-friendly production, smart use, recycling and commercial exploitation of phosphorus-based processes and materials that use the precious element phosphorus in a sustainable manner. This approach should lead to fundamental insights into sustainable technologies and create an ideal platform for the training of young, ambitious researchers in a superb collaborative European setting. SusPhos will educate 14 broadly-oriented researchers at the interface of synthetic chemistry, catalysis, materials science, process chemistry, industrial phosphorus chemistry, and technology transfer. SusPhos’ intense training module combines the complementary strengths of nine academic and three industrial teams to promote intersectoral mobility of top-class multi-skilled researchers to enforce cross-fertilization of enhanced research synergies between the public and private European chemical sector. In its dual-mentor programme each of the ESRs and ERs will be supervised by one mentor from academia and one from industry to ensure an outstanding training in both sectors. The training programme uses highly innovative and timely methodologies to provide comprehensive multidisciplinary training of a new generation of young researchers capable of understanding and applying green chemistry to the conservation of phosphorus by environmentally benign conversions. Our SME Magpie Polymers and leading chemical companies Thermphos, Arkema and DSM will ensure rapid and effe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'GREEN NIGHT'.

assistant: **Innovation**

Taking its name from the European Green Deal, GREEN NIGHT stands on the main pillars and policy areas of the strategy with a general outlook on how science can support the aims and targets set out for Europe?s near future. The current global climate emergency urges an immediate and large-scale response from the countries. For the first time, climate change and environmental issues are seen to have migrated to the center of global policymaking. As a result, GREEN NIGHT highlights the importance of raising awareness of the general public, especially young people, on the necessity of the green transformation for the future of our planet. GREEN NIGHT acknowledges that it is essential to protect and restore natural ecosystems for sustainability. Doing so, GREEN NIGHT will focus on main action areas of energy, food, waste, and transportation, and demonstrate the leading role that sciences have in how to achieve this transformation. GREEN NIGHT project brings together four of the ten higher education institutions in Izmir, Turkey as well as the provincial directorate of national education. The consortium represents the scientific research ecosystem and educational management in ?zmir. The HEIs cooperate in local, national and international research projects, joint social responsibility campaign and activities all of which create strong institutional linkages between HEI partners. IZMEM, being the highest local public body responsible for the coordination of educational activities in preprimary, primary and secondary level in ?zmir, brings the public educational expertise into the project.The night activities will be carried out in four campuses around the city, each with its general theme selected from the main topics. Scientists and researchers from a wide range of discipline
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Optimization of stem cell therapy for clinical trials of degenerative skin and muscle diseases' (OPTISTEM).

assistant: **Concept**

This proposal aims to develop and implement efficacy of clinical trials with adult, tissue stem cells for degenerative diseases of epithelia and skeletal muscle. Extraordinary progress in the understanding of several key features of stem cells has been rapidly translated into novel cell therapy protocols that have yielded positive results in pre-clinical models of genetic and acquired diseases and in the first clinical trials. Much remains to be done on the basic biology of stem cells to provide new tools for cell therapy trials. Also transplantation related issues, such as engraftment, angiogenesis, tissue remodeling and immune response remain to be addressed. In general, cell therapy necessitates a continuous cross-talk among biologists and clinicians as well as crossing boundaries among different tissues/diseases. Despite many structural and functional differences, epithelia and skeletal muscle share some key features such as spatially ordered cell architecture, centered on a supporting basal lamina to which stem cells are anchored. Indeed mutations in structural proteins linking the cell membrane to the basal lamina are responsible for similarly devastating diseases such as muscular dystrophies and epidermolysis bullosa. A multi-tissue approach allows jointly addressing and solving not only scientific and clinical problems but also regulatory and ethical issues related to these novel procedures. Finally, sharing high valued dedicated platforms such as large animal facilities and GMP cell culture facilities increases performance and reduces costs. Based on these considerations, a network of internationally recognized experts in muscle and epithelial cell biology, immunology, angiogenesis, and molecular pharmacology with two stem cell-based Companies has been assemble