RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Accelerating drug repurposing for rare neurological, neurometabolic and neuromuscular disorders by exploiting SIMilarities in clinical and molecular PATHology' (SIMPATHIC).

assistant: **Innovation**

Drug repurposing can fill an important gap for rare disease patient groups with large unmet medical needs. In comparison to traditional drug development, drug repurposing reduces the time and costs for drug development, regulatory approval, and market authorization. Yet, we need to increase the efficiency of the drug repurposing pathway to provide broader access to new therapeutic modalities for larger groups of patients. SIMPATHIC’s main objective is to accelerate drug repurposing for rare neurological, neurometabolic and neuromuscular disorders. SIMPATHIC’s main accelerating innovation is the simultaneous drug development for groups of patients with different genetic diagnoses but overlapping neurological symptoms and molecular pathomechanisms. SIMPATHIC’s key outputs accelerating the drug repurposing pathway include: Standard operating procedures for culturing stem cell-derived neuronal cell models with proven relevance for clinical symptoms and amenable to high-throughput drug screens; New drug repurposing candidates with proven efficacy in advanced brain-on-a-chip and 3D brain organoid models, as demonstrated by reversal of molecular biomarker signatures and cellular readouts associated with clinical symptoms; Designs of innovative basket clinical trials to which patients with different disorders are recruited, utilizing and aggregating personalized clinical endpoints; A training module for patients and patient organizations to empower them as drivers of the drug repurposing pathway; Blueprints for intellectual property strategies, business models, regulatory dossiers and patient access strategies, developed in co-creation between all relevant stakeholders. SIMPATHIC’s proof-of-concept for the simultaneous development of repurposed drugs for multiple indications wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of an energy management system for hotels with standard sensor/actuator components and the european installation bus' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Today the energy management of multifunctional buildings like Hotels consists o f island solutions Typical these are various centralized systems for management of heating, electricity, room access control, fire protection, time management , house breaking with individual wiring. The objective of: this project is the development of general demonstrator for an energy management system with standa rd sensor/actuator components and the European Installation Bus (EIB) for heati ng, lightning window status, air conditioning, guest presence detection and an interface to the Hotel managemen systems. The information available in the Hote l/Room management system will be used for ar effective energy management. It is expected to reduce total energy costs by 20 %. Installation cost' will be redu ced because of the integration and multifunctional use of sensors and actuators for systems like access control, fire protection, Single room energy managemen t, break in protectior and hotel visualization and communication only by the EI B. After an analysis of hotel operations and the building automation a demon strator will be defined developed and installed in a suitable hotel. Results wi ll be evaluated and disseminated by, exploitation workshops. The project has been prepared by means of an exploratory award under the Joule programme, area 2.1 Rational use of energy in buildings . Five SMEs from the industrial secto r building automation one manufacturer of EIB components and three R&D performe rs form the consortium. The demonstrator enables the partners to show the advan tages of the European Installation Bus technology to other interested hotels, d evelop it into a commercial product after the end of the project and to strengt hen the competitiveness of EIB techmology compared to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'PERISTALTIC MULTISTAGE MICRO-MECHANICAL PUMP FOR NEXT GENERATION DIABETES MANAGEMENT' (PRISMA), addressing dissemination and exploitation.

assistant: **Impact**

More than 30 million people are living with diabetes in the EU, with a prevalence expected to grow to over 10% of the adult population by the year 2030. Despite modern treatments, the life expectancy of patients with type 1 diabetes remains reduced as compared to healthy people due to lack of efficient therapies. An “artificial pancreas” is the ultimate solution for such therapy: a device performing a continuous glucose measurement and pumping precise doses of insulin and other hormones needed for the treatment. The closed-loop artificial pancreases promises an agile solution where the diabetes patients may effectively feel relieved from their disease as the blood glucose level is automatically controlled using a mixture of multiple hormones simultaneously. Such an innovative technology alleviates the burden of carbohydrate counting and automatically ensuring the optimal glucose level at all times. However, a small, lightweight device which is able to administrate multiple hormones is still lacking. This proposal seeks to develop a novel micro-peristaltic pump on silicon, to be integrated with a transdermal smart patch loaded with the three hormones delivered by silicon microneedles. The PRISMA innovation is possible thanks to the achievements of the FET-OPEN project “BioWings”, where the concept of thin-film micropump using actuating materials has been prototyped.


**Keywords:** three hormones therapy, diabetes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Winter Climate Variations and Plant Death in the North: a Workshop to share understanding of managed and natural systems' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

At high northern latitudes extreme winter cold, or rapid fluctuations of temperatures above and below freezing, can cause damage and death of perennial agricultural/silvicultural crops, and plants within unmanaged ('natural') ecosystems. Winter damage can also operate indirectly via microbial pathogens and/or insect pests, and can have knock-on effects on vertebrate herbivores. The prospect of anthropogenic climate change - with warming of greater magnitude during the winter than the summer, and increased frequency and intensity of climatic extremes - has increased the focus on the effects of variation in winter climate. A seminar held in Iceland in May 2000 highlighted (i) the differences between research approaches used for managed and natural systems, and (ii) the very limited exchange of information between the research communities. Basically, agricultural and forestry scientists have an in-depth knowledge of the genetic, physiological, biochemical and phenological mechanisms by which crop monocultures respond to climate change. In contrast, researchers on natural systems have greater understanding of the phenology, growth and reproduction of a much wider range of plant species under field conditions, but relatively little understanding of the detailed mechanisms controlling responses. Thus the two research communities have markedly different, but complementary, expertise.Euro Workshop objectives & format: The workshop is designed to bring together researchers from managed and natural systems to:- Summarise/compare understanding of the direct and indirect mechanisms/processes of winter damage in managed and natural systems in northern regions;- relate this understanding to assessment of system and regional variations in the potential responses to winter climate chan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'ULTIMO - Advancing Sustainable User-centric Mobility with Automated Vehicles' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

During the past few years many projects and initiatives were undertaken deploying and testing Automated Vehicles (AVs) for public transportation and logistics.  However in spite of their ambition, all of these projects stayed on the level of elaborated experimentation and never reached the level of a large-scale commercial deployment of transport services. The reasons for this are many, the most important being the lack of economically viable and commercially realistic models, the lack of scalability of the business and operating models, and the lack of user oriented services required for large end-user adoption of the solutions. The ULTIMO project will create the very first economically feasible and sustainable integration of AVs for MaaS public transportation and LaaS urban goods transportation.  ULTIMO aims to deploy in three sites in Europe 15 or more multi-vendor SAE L4 AVs per site. A user centric holistic approach, applied throughout the project, will ensure that all elements in a cross-sector business environment are incorporated to deliver large-scale on-demand, door-to-door, well-accepted, shared, seamless-integrated and economically viable CCAM services. We target the operation without safety driver on-board, in a fully automated and mission management mode with the support of innovative user centric passenger services. ULTIMO’s innovative transportation models are designed for a long-term sustainable impact on automated transportation in Europe, around the globe and on society. The composition of the consortium ensures the interoperability between multiple stakeholders by making adoption of new technology at minimum costs and maximum safety. The integration of the ongoing experiments of previous AV-demonstrator projects ensures highest possible technical and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Upscaling and commercialization of a highly efficient wood pellets fired steam engine CHP for heat and power generation' in the context of a Horizon 2020 call.

assistant: **Objectives**

Upscaling and commercialization of a highly efficient wood pellets fired steam engine CHP for heat and power generation.The aim of this project is the upscaling and commercialization of a developed CHP (combined heat and power generatingsystem) comprising a highly efficient wood pellets fired steam engine. The CHP power output is 50kW electrical and 175kWthermal power with 20% electrical and 90% overall efficiency based on wood pellets . We achieve these test bench provenparameters by developing a steam engine technology with a new approach. The technology readiness level is TRL7. ThisCHP technology has a potential energy costs saving rate of up to 84% for customers compared to natural gas heating and grid power. This high efficiency is achieved by applying steam inlet conditions in excess of 500°C and 100bar. This technology is developed with the focus on costs, reliability, efficiency and mass production. The basic patent process will be finished in 2014. By applying this technology throughout the EU, the carbon dioxide production could be lowered significantly as the fuel for this technology is wood or any other solid biomass or organic waste, which is burned highly efficient within the process. As this technology has base load capability, this would be a perfect supplement for the existing renewable energy systems like photovoltaics and wind.Also, the dependency on fossil energy like oil and gas could be lowered. As the used fuel grows everywhere in the EU, theprice of energy produced by this technology will be lower. Moreover the price will be much more time stable as there arethousands of wood suppliers who make this market much more competitive than the existing fossil fuel market with themonopoly of only a few suppliers.The aim of of the feasibility study is to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Initial Training Network: Lateralized Attention Networks' (ITN-LAN).

assistant: **Innovation**

The proposed Initial Training Network for Lateralized Attention Networks (ITN-LAN) brings together 6 research teams with established international reputations and, more importantly, is founded on well established collaborations.  The long-term scientific objectives of the proposed ITN-LAN are: (1) To validate and standardize a behavioural battery for assessing the attentional networks of the two cerebral hemispheres and their interaction,  (2) To study its neurophysiological correlates using EEG/ERP, fMRI, NIRS and TMS,  (3) To assess methods for modulating the attention networks in each hemisphere and their interaction using: (i) biofeedback of the participants own ongoing EEG or fMRI, (ii) TMS to generate selective 'virtual lesions' of hemispheric attentional networks.   The focus of the current proposal is to assess critically and rigorously the effectiveness of biofeedback in modulating attention, a goal which has both basic and applied aspects. Common to both aspects is our ability to harness cortical plasticity in the service of ameliorating not only acquired, but also congenital attention deficits. The clinical application has commercial potential and this will be pursued by the industry associated partner (Bio-Keshev). The proposed ITN-LAN offers a comprehensive range of research methods and theories in attention research. First, we cover ALL the non-invasive research methods applied in this field, and second, we look at attention processes at all levels, from sensory to frontal cortex regions, from childhood to old age, and from normal performance to acquired and developmental disorders. We ask to fund 312 person-months, mostly (92%) ESR. One of the centres is located in a less-favoured region. We are privileged to have Prof. Michael Posner as our consultant, b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Structure-function relationships in proteins: determination of ionization properties of proteins' under Fourth Framework.

assistant: **Concept**

Problem: A high resolution structure alone cannot provide a full understanding of protein structure-function relationships. It is necessary to know also the forces that form the basis of protein functional properties. Among these forces, the fundamental importance of electrostatic interactions is evident from the pH, ionic strength and counterion dependence of protein function. No general and comprehensive approach exists to predict the pK values of titratable groups and hence the ionization behaviour of proteins. Existing theories and computational methods do not account for the conformational heterogeneity of proteins in solution nor for the relationship between electrostatics and the thermodynamics of protein-solvent interactions. Solution The main goal of the work proposed in this project is to improve this situation by developing better theoretical and computational methods to describe electrostatic interactions. This goal will be achieved through a combination of experimental and theoretical methods, using well defined model proteins. For this purpose a multi-disciplinary consortium of 7 teams from 5 Member States of the EU has been drawn together. Among them, 4 are academic groups and 3 are industrial enterprises. Activities (i) Determination of the solution structures of proteins and their pH dependent conformational equilibria by improved multidimensional heteronuclear NMR spectroscopy. (ii) Analysis of the effect of electrostatics on the thermodynamics and kinetics of protein folding and catalysis. We will use leucine zippers and ribonuclease T1 as model proteins. Both proteins are ideally suited for a comprehensive analysis of the structural and thermodynamic parameters that form the basis of protein electrostatics. Results will be used to derive a more accur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Elucidating the Spatial and Temporal Dynamics of Acute Myeloid Leukemia Progression Using Functional Omics and High-Throughput In Vivo Screening' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Advances in sequencing-based phylogenetic studies applied to cancer evolution have led to the observation that the linear accumulation of oncogenic alterations over individuals lifespan does not match the late life pattern of cancer incidence. It has thus become clear that beyond the sequential accumulation of oncogenic driver mutations, additional factors also support cancer outgrowth. The temporal and spatial dynamics of tumor evolution represent two of the most critical mutation-independent variables to consider. Hence, we hypothesized that the dual features of aging and spatial dissemination promote critical fitness gains that are at least as significant as driver mutations in cancer. The goal of this proposal is to investigate the spatial and temporal determinants of tumor progression and to dissect the contributions of these processes to cancer pathogenicity.Due to its quite unique occurrence pattern and propagation characteristics, Acute Myeloid Leukemia (AML) is the prototypical disease model that we have elected to template such spatiotemporal-dependent features of disease development. To study these features, we engineered two mouse models of leukemia dissemination and aging using serially-transplantable MLL-AF9-driven leukemic blasts. Using these two models, we propose to i) combine metabolomic- and epigenomic-based profiling to portray the spatiotemporal dynamics of leukemia growth; ii) deploy single-cell transcriptomics coupled with lineage tracing experiments to reveal the pre-deterministic attributes of such dynamics; and iii) leverage innovative multimodal in vivo shRNA and CRISPRa screening approaches to pinpoint and functionally characterize the critical age- and dissemination-related effector genes involved in leukemic progression. The comprehensive a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Signs of Early Adaptation to Climate Change' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Nearly 8% of deaths are attributable to ambient temperatures, but little is known about the future impact in a warming world. I conducted studies in high-impact journals showing that this death toll can be largely reduced if a substantial degree of adaptation to ambient temperatures takes place. Adaptation strategies have been increasingly implemented in Europe in recent years, but the last IPCC report indicated that evidence of their effectiveness is still lacking. I postulate that adaptation measures are starting to generate positive benefits for the wellbeing of societies, including an adaptive response to climate change, but the degree to which they are effectively reducing human vulnerability is largely heterogeneous among and within European societies. I aim to describe the major sources of vulnerability, and if, which and to what extent societies have already started to adapt to changing conditions. Towards this aim, I will use predictive models to quantify the potential beneficial effect of early adaptation strategies through the attribution of temporal changes in human vulnerability. For that purpose, I will generate a massive database with daily counts of death for different subdomains and spatial resolutions, including data for countries, regions, cities and neighbourhoods, together with the best available climate, air pollution, influenza, socioeconomic and demographic datasets. In addition, I will combine the best epidemiological techniques with weather and climate forecasts and climate change simulations to perform an integrated predictability assessment of mortality risks and provide a realistic re-estimation of the likely range of future heat- and cold- attributable mortality. Expected results will provide a better understanding of the real impact of ada