RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Role of LASP1 and PDLIM4 in Stress Fiber Dynamics and Mechanoresponsive Signaling' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The LIM domain proteins LASP1 and PDLIM4 are associated with the actin cytoskeleton, and implicated in many diseases. However, their precise molecular functions are poorly understood. Recent protein interaction studies from my host laboratory provided evidence that these two proteins associate with stress fibers (SFs), the contractile actomyosin structures of non-muscle cells. Distant homologues of LASP1 and PDLIM4 are also present in muscle sarcomeres, suggesting a potential structural role of these proteins in SFs. However, several other LIM domain proteins are involved in a wide-variety protein-protein interactions and signaling pathways, suggesting possible roles for LASP1 and PDLIM4 in signal transduction, especially in mediating mechanosensing in SFs. Indeed, previous studies proposed that LASP1 is a possible regulator of translation, whereas PDLIM4 may function as an adaptor between the cytoskeleton and kinases. The aim of my work is to elucidate the molecular functions of PDLIM4 and LASP1 using a combination of proteomics, cell biological, genetic and biochemical approaches. My specific interest is to uncover whether PDLIM4 and LASP1 are structural components of stress fibers, or if they function as mechanosensitive regulators of translation or intracellular signaling. The findings will uncover the roles of PDLIM4 and LASP1 in cytoskeleton organization, potentially providing new insights into various diseases, including cancer. Additionally, understanding the interplay between SF-mediated mechanosensing and translation may reveal new mechanisms by which cells respond to mechanical cues. Overall, this study will broaden our understanding of SF-signaling, and has potential implications for therapeutic interventions in diseases linked to SF-dysregulation.


**Keywo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MuscleUp - Towards an Interface for Detailed Musculoskeletal Models' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Computer simulations are an increasingly popular tool for investigating and enhancing our knowledge of the human body. They can provide valuable insights and provide in silico experiments to test hypotheses of complex biological relationships. Due to the inherent complexity of the structures and the highly-specialised area of expertise of the researcher/user, computational models are often reduced to the components that are essential to fulfil the least amount of assumptions such that their results can be interpreted and discussed within a specific context. The purpose of this proposal is to bring together researchers with complementary expertise to develop (i) detailed models of complex musculoskeletal systems (the ‘next generation models’) and (ii) a novel web interface to disseminate those models. The improvement of models existing in research groups participating in this proposal will include the spine, hip, pelvic floor, and the tongue. A special focus will be on the inclusion of 3D soft tissue structures, e.g. skeletal muscles, and their material descriptions. The aim of the interface is to provide easy access to such near-complete descriptions of complex models. The interface is guided by the development of the models and will appeal to similar concepts as standard web pages and the ability to include 3D scenes of models. This can only be achieved through an international network of well-established research groups with expertise in material science, computational science, software design, whole organ modelling, modelling biotribological systems, clinical contacts, biomechanics, sports science, etc. The network includes the Cluster of Excellence for Simulation Technology, SimTech (University of Stuttgart, Germany), the Institute of Medical and Biological Engineer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'SUrrogate measures for SAFE autonomous and connected mobility'.

assistant: **Innovation**

SUperSAFE ""SUrrogate measures for SAFE autonomous and connected mobility"" will address the problem of the safety evaluation of the interaction between conventional vehicles and connected and automated vehicles (CAVs). The project builds on the notion that vehicle automation is posing new risks that the traditional accident-based and proactive safety analysis methods are unable to investigate. In SUperSAFE, I will select the relevant variables drew on the newly identified risks posed by CAVs, and with these I will develop a new proactive method based on surrogate measures of safety for studying the effects of the physical and digital infrastructure on the interaction between road users in a mixed-mobility environment. Also considering the benchmarks for cities’ liveability and transport sustainability that include road casualties as a primary factor, the European White Paper on Transport calls to reach zero fatalities by 2050 following Vision Zero’s policy (zero serious casualties). Recent statistics indicate a reduction of traffic accidents but also that this development has slowed and additional efforts are required. At the same time, CAVs are already a reality. Tendency towards vehicle automation is even more evident in the European policies which encourage member states to push with the introduction of vehicles with advanced driver assistance systems. However, the road towards full automation is still not open because there is a fear of crashes/injuries and low acceptance of potential CAV accidents. This is mainly because the CAVs’ behaviour vis-a-vis the conventional vehicles on the road and the digital and physical infrastructure is still unknown. To meet these rapidly approaching needs, I propose SUperSAFE, which will contribute to attaining the aforementioned E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Membrane Interaction Modulates RNA Secondary Structures and Phase Separation' in the context of a Horizon Europe call.

assistant: **Objectives**

To maintain homeostasis, cells utilize compartmentalization, traditionally achieved through membrane-bound organelles. However, recent discoveries have highlighted the importance of membrane-less compartments, known as biomolecular condensates (BCs), which form via liquid-liquid phase separation (LLPS). BCs, rich in nucleic acids and proteins, create distinct chemical environments that regulate key metabolic processes and can be temporally controlled. Dysregulation of BCs is linked to diseases such as cancer and neurodegeneration. Whilst the role of proteins in LLPS has been extensively studied, nucleic acids' contribution has been underexplored and attributed solely to electrostatic effects. More recently, it has been demonstrated that nucleic acid alone can drive phase separation, and G-quadruplex (G4), a non-canonical secondary structure, has been identified as a key element. G4s are formed in guanine-rich sequences and can act as crosslinking elements, promoting multivalent interactions required for LLPS. However, understanding the molecular mechanisms of RNA-driven phase separation remains incomplete. A key challenge is identifying mechanisms that reduce the critical concentration required for RNA-based phase separation, making models more biologically relevant. In MIMoSeS, I investigate the role of phospholipid membranes in promoting RNA condensation by selectively recruiting specific RNA secondary structures to their surface, thereby lowering the concentration needed for phase separation. While this mechanism is known for protein-based BCs, it is still underexplored for RNA. MIMoSeS will identify and describe the interplay of lipid membranes and RNA G-quadruplex structures as a putative mechanism for Liquid-Liquid Phase Separation and will provide new insights to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Knowledge management platform for clinical use of brain data' under Horizon 2020.

assistant: **Concept**

The connectome is a map of all neural connections in the brain that can provide information about the brain’s (re)wiring in neurological diseases, injuries, or drugs responses. The use of connectomes in clinical practice has enormous potential to improve treatment efficacy, enhance patient stratification, disease characterization, and ultimately diagnosis. However, the means to clinically utilize connectomes are limited. Therefore neurologists still rely on subjective analysis of brain scans. Although the use of big data tools in neuro-diagnostics is growing, no commercial application for clinical practice is available yet. Biomax developed the first commercial solution to translate big connectome data into clinically relevant information: NeuroXM. In combination with patients’ clinical data this can be valorized to improve neuro-diagnosis. NeuroXM has successfully undergone pilot studies at two major institutes. The proprietary NeuroXM platform includes all features and security levels that are required in the clinic. Biomax is a strong bioinformatic SME with 20 years’ experience, including >25 European grants, 5 successful bioinformatic products, and a pioneering reputation.NeuroXM targets a very large and diverse neurology market with multiple clinical applications, e.g. diagnosis of dementia using brain imaging, detecting brain wiring “disconnections” in schizophrenia, and establishing treatment efficacy (longitudinal assessments of the connectome). This SME Phase 1 project will assess the feasibility of these different applications, which will help Biomax to establish a Go/No-go for further clinical validation for the specific clinical applications. With a strong first mover advantage and freedom to operate, NeuroXM has the potential to become the gold standard for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Evaluating new technologies for surgical repair of inguinal hernia - a concerted action based on European randomised controlled trials' under Fourth Framework.

assistant: **Concept**

Objective:The objective is to clarify the place within European surgical practice of two novel approaches to inguinal hernia repair by performing a systematic review, including meta-analysis, of data from randomised trials. Tension-free open and laparoscopic techniques will be compared with conventional open methods, in respect of clinical effectiveness, particularly freedom from long-term pain and hernia recurrence, and health economics outcomes.Brief Description:Repair of inguinal hernia is performed over half a million times each year in Europe. The standard method changed little over the 100 years up to the late 1980s: conventional, open repair relies on tension on the suture line to close the defect and avoid recurrence. Recently, there have been two revolutionary developments in surgical methods. The first is 'tension-free' open repair, associated with the name of Lichtenstein, and the second is the use of minimal access, laparoscopic techniques. Both appear to have short-term advantages, but their cost-effectiveness and long-term clinical performance is uncertain. Evaluative evidence will be most reliable if it is derived from randomised controlled trials in which the surgeon's approach has been chosen by random assignment. Within Europe, at least 35 such trials are either underway or recently completed and it is these which are the focus of this project. The aim is to synthesise data from all these studies using meta-analysis to provide much clearer evidence of effects than the individual trials alone. The project will do this by: increasing precision; improving generalisability; examining sub-groups; exploring the effects of 'minor' modifications in surgical technique; and expanding economic analyses.Completed and ongoing randomised trials of tension-free or la
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High Efficiency Access Solution for the Internet of Things' in the context of a Horizon 2020 call.

assistant: **Objectives**

GreenWaves Technologies’ strategy is to offer a high-data-rate radio interface, Green-OFDM, to LPWAN networks. Green-OFDM brings a significant cost advantage and more autonomy than Wi-Fi and LTE alternatives, while maintaining the existing network architecture and functionalities of LPWANs, which neither Wi-Fi nor LTE can do. There is a consensus among experts regarding the explosion in the number of connected objects in the coming years and certainly a speculative inflation. The company’s core strategy is to boost the transfer speeds of LPWANs from 10 kbit/s to few Mbit/s, upgrading them to high-data-rates networks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'IntelligenT twinning of WIreless Networks for 6G' (TWIN6G).

assistant: **Innovation**

New emerging applications demand performance requirements that exceed the capabilities of 5G networks, requiring a rapid evolution towards 6G networks. 6G is expected to offer data rates of the order of Tbps, time responses of the order of sub-milliseconds, and localization accuracies of the order of sub-centimeter, while meeting united nations’ sustainable development goals. This calls for the deployment of paradigm shifting technologies and design methods, and the use of new frequency bands, including the deployment of reconfigurable metamaterial transceivers, the integration of communication and sensing functionalities, and the migration towards the sub-terahertz spectrum. This will make 6G an extremely complex system to model and optimize.   Digital twins (DTs) and machine learning (ML) are two vital technologies to tackle the modeling and optimization complexity of 6G. A DT is a virtual replica of the 6G physical network. DTs are essential to model complex systems in real time, providing valuable insights into their behavior and performance, as well as for generating enormous amounts of training data. ML provides advanced analytics and decision-making capabilities, enabling 6G communication systems to self-optimize, self-configure, and self-heal. The integration of DTs and ML offers a powerful approach for modeling, simulating, and optimizing 6G communication networks. It is expected to lead to the creation of a highly intelligent and dynamic network environment, where physical and virtual objects interact seamlessly, and where decisions are made and executed in real time.   TWIN6G is the first-of-its-kind staff exchange research and transfer-of-knowledge program whose aim is to build the world’s first open-access and open-source digital twin emulator to design 6G
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Markets and their limits' (MARKLIM).

assistant: **Innovation**

This project aims at investigating new frontiers in the regulation of individuals, firms and the state. It will build on traditional tools, game theory, information economics and mechanism design, further these tools and apply them to a wide range of important economic issues. It will be organized around five topics:- Morality and markets. The goal is to organize the disparate evidence from economics and psychology on how moral behavior is generated, to provide a coherent framework on how to think about moral issues to study their implications for organizations and to run experiments on the matter.- Intellectual property and public policy with the writing of a monograph and an empirical analysis of the standards-patent pool interface. - Industrial organization, and more specifically two-sided markets and merger policy. The research will apply two-sided market economics to shed light on the “must-join platform” argument and on potential regulations of the intermediation activity.  - Debt crises including various and yet little studied aspects of banking and sovereign debt crises.  - Investigate the political economy of regulation, and much more generally political science.Finally, the project will emphasize methodological aspects. It will extend the concept of Markov Perfect Equilibrium to games of imperfect information. On the mechanism design front, it will pursue a new line of research on “positive selection”.This methodological project will branch into a more applied project. It will consider an organization or a country run by a ruler/dominant group that is hostile toward a minority on religious, ethnic, linguistic, cultural, wealth or sexual-orientation grounds. It will investigate the dynamics of compositional change in such environments. Also, the project will co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Unraveling the code of DNA replication origins and its link with cell identity' (ORICODE), addressing dissemination and exploitation.

assistant: **Impact**

DNA replication origins remain poorly defined in metazoans, in contrast to bacteria or S. cerevisiae. We believe that, in eukaryotes, a differential encoding of chromosomes by DNA replication origins is instrumental for the acquisition of cell identity during development. We wish to decipher this encoding, to determine whether it is linked to gene expression, and identify the mechanisms used to build a replication origin. First, we will unravel the origins code in mouse undifferentiated pluripotent cells with a genome-wide approach and correlate the replication origins' map with other chromosomal genetic or epigenetic features. The origins code will be deciphered also in the same cells when engaged into a specific (neural) differentiation. We predict that this differential mapping will identify constitutive and regulated origins, the latter specific to gene domains expressed in differentiation and providing cell identity. In the second axis of this project, we will identify proteins that constitute a replication origin. We will exploit two novel screening procedures developed in our laboratory. The chromosome-trap" assay uses DNA beads to collect factors assembling at replication origins, using Xenopus cell-free systems. The "Replication foci capture" method allows the isolation of replication origins at their in-situ chromosomal location. Key objective 1: to unravel DNA replication origins' code in pluripotent embryonic stem cells. Key objective 2: to identify a link between replication origins and cell identity . Key objective 3: to investigate whether replication origins are responsible for the spatio-temporal organization and cell identity regulation by Homeobox domains. Key objective 4: to perform a functional analysis of replication origins by SiRNA silencing of d