RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nativism, Islamophobism and Islamism in the Age of Populism: Culturalisation and Religionisation of what is Social, Economic and Political in Europe' under Horizon 2020.

assistant: **Concept**

The main research question of the study is: How and why do some European citizens generate a populist and Islamophobist discourse to express their discontent with the current social, economic and political state of their national and European contexts, while some members of migrant-origin communities with Muslim background generate an essentialist and radical form of Islamist discourse within the same societies? The main premise of this study is that various segments of the European public (radicalizing young members of both native populations and migrant-origin populations with Muslim background), who have been alienated and swept away by the flows of globalization such as deindustrialization, mobility, migration, tourism, social-economic inequalities, international trade, and robotic production, are more inclined to respectively adopt two mainstream political discourses: Islamophobism (for native populations) and Islamism (for Muslim-migrant-origin populations). Both discourses have become pivotal along with the rise of the civilizational rhetoric since the early 1990s. On the one hand, the neo-liberal age seems to be leading to the nativisation of radicalism among some groups of host populations while, on the other hand, it is leading to the islamization of radicalism among some segments of deprived migrant-origin populations. The common denominator of these groups is that they are both downwardly mobile and inclined towards radicalization. Hence, this project aims to scrutinize social, economic, political and psychological sources of the processes of radicalization among native European youth and Muslim-origin youth with migration background, who are both inclined to express their discontent through ethnicity, culture, religion, heritage, homogeneity, authenticity,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CHerenkov Light mOdulE for time-of-flight Positron Emission Tomography' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Time-of-flight positron emission tomography (TOF-PET) is the standard-of-care in cancer detection. TOF-PET scanners’ performance is dependent on the radiation detectors they use. Improving time and spatial detection features in such detectors will dramatically impact the diagnostic capacity of TOF-PET systems. The goal of this project is to build a gamma detector concept for TOF-PET able to improve the time resolution and spatial segmentation of state-of-the-art detectors by a factor of up to 7 and 10, respectively, without additional production costs. CHLOE-PET is a forward-looking gamma detector design for TOF-PET able to exploit the new photodetector technologies that are currently under development and will become available within the next 5-to-10 years. The novelty of the proposed design lies in using Cherenkov light as a prompt time source, using an innovative geometry optimized to maximize light collection, and employing photodetectors with small pixel pitch. This project is the first attempt to build a detector module scalable to a full-size system that can be used in a hospital setting. The CHLOE-PET detector will consist of bismuth germanate (BGO) crystals with 12 mm thickness and will combine the readout of scintillation and Cherenkov light. CHLOE-PET will provide an effective 3D segmentation of 2x2x2 mm3, an intrinsic photon time spread of 20 ps, and no intrinsic radiation background (unlike state-of-the-art TOF-PET detectors). Such improvements will allow increasing the signal-to-noise ratio of images by >2-fold, to be able to detect lesions of 2 mm size (>3 times the current performance), to build portable high-performance organ-dedicated TOF-PET systems, and to universalize the use of dynamic TOF-PET studies. The combination of these outcomes will provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Electron Capture Decay of 163Ho to Measure the Electron Neutrino Mass with sub-eV sensitivity' in the context of a Seventh Framework call.

assistant: **Objectives**

HOLMES is aimed at directly measuring the electron neutrino mass using the electron capture (EC) decay of 163Ho.The measurement of the absolute neutrino mass represents a major breakthrough in particle physics and cosmology. Due to their abundance as big-bang relics, massive neutrinos strongly affect the large-scale structure and dynamics of the universe. In addition, the knowledge of the scale of neutrino masses, together with their hierarchy pattern, is invaluable to clarify the origin of fermion masses beyond the Higgs mechanism.The innovative approach of HOLMES consists in the calorimetric measurement of the energy released in the decay of 163Ho. In this way, all the atomic de-excitation energy is measured, except that carried away by the neutrino. A finite neutrino mass m causes a deformation of the energy spectrum which is truncated at Q-m, where Q is the EC transition energy. The sensitivity depends on Q - the lower the Q, the higher the sensitivity - and 163Ho is an ideal isotope with a Q around 2.5keV. The direct measurement exploits only energy and momentum conservation, and it is therefore completely model-independent. At the same time, the calorimetric measurement eliminates systematic uncertainties arising from the use of external beta sources, as in neutrino mass measurements with beta spectrometers, and minimizes the effect of the atomic de-excitation process uncertainties.HOLMES will deploy a large array of low temperature microcalorimeters with implanted 163Ho nuclei. The resulting mass sensitivity will be as low as 0.4eV. HOLMES will be an important step forward in the direct neutrino mass measurement with a calorimetric approach as an alternative to spectrometry. It will also establish the potential of this approach to extend the sensitivity down to 0
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Immunological mechanisms of protection against classical swine fever virus: towards the development of new efficacious marker vaccines' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The high costs of a Classical Swine Fever (CSF) -outbreak, the social impact and resistance against destruction of pigs have led to reconsideration of emergency vaccination against CSF. The application of marker vaccines that can provide early protection might contribute to improved intervention and control strategies and might limit the duration and costs of an outbreak. The objective of this project is to understand the immune mechanisms underlying protection against CSF, in particular the mechanisms involved in early protection against clinical signs of CSF and in the reduction of (horizontal) virus transmission. The knowledge about relevant viral components, and about the quality of the vaccine-induced immune response may contribute to the future development of new and safe marker vaccines that can induce a fast protective immune response.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Innovative protective and corrosion resistant coating systems for glass and other laboratory and chemical industry materials' to be submitted under Fourth Framework.

assistant: **Abstract**

The work performed through the CHEMRESIST project has allowed to synthesise sol-gel systems with various possibilities of application. First, there is the strong alkali protection of CeO2-TiO2 (system 6, thickness 250 nm) on flat borosilicate glasses with a spin-coated primer usable for windows or other plane glasses. Second, the thick glass-like coatings with sodium (system 1) and especially potassium (system 2) with thicknesses of 2 - 3 µm increase the bending strength of borosilicate glasses up to 70 %. Third, a further advantage of the CeO2-TiO2 coating is the UV absorption below 380 nm. The coating could be used to protect UV decomposing agents stored in bottles with the new coating. Particularly in the chemical industry but also in the pharmaceutical, plastics and other areas, corrosion of glass equipment and laboratory articles is a major universal problem. Different solutions exist such as use of plastic coatings (PUR, Polyester), but these coatings are generally limited to low temperature applications. A particular problem is illustrated by hydrofluoric acid against which even glass is not resistant. The objective of this project is the development of technologies to prepare protective coating systems on large scale glass containers and instruments capable of resisting alkali and acid attack (including hydrofluoric acid) at medium and high temperatures at a cost comparable to polymer coatings. Therefore the industrial objective of the SME partners (Gras Plus, HWS Labortechnik, VS Technologies, G. Farley & Sons) is to use new NANOMER(R) coatings (NANOMER(R): organicinorganic nanocomposites), prepared by the sol gel process at the R&D partner INM. These coatings combine the advantages of organic coatings (i.e. flexibility, transparence, etc.) with the specific ad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Integration and international migration: pathways and integration policies'.

assistant: **Innovation**

According to UN assessments, there are 214 million international migrants worldwide and another 740 million internal migrants . The OECD highlights that there seems little likelihood of substantial reductions in numbers of international migrants in the current decade . Rises in global population, new demographic trends including ageing population, environmental deterioration and an increased globalisation of the economy are some of the factors which will encourage emigration flows in coming years. International migration, firmly at the top of the EU’s political agenda, must be analysed from the integration perspective as the key factor for the future cohesion of European societies.The INTEGRIM programme is developed by a sound and well established network of 8 full partner academic institutions and 6 non-academic associated partners from the private and public sector, civil society and international organisations with outstanding research and training credentials on migration and integration issues. The aim of this programme is to structure the existing high-quality research capacity on migration and integration policies and processes in Europe through 480 person-months of Early-Stage Researchers. INTEGRIM will consider processes and policies concerning integration of foreign nationals within EU countries, including third-country nationals and European nationals migrating to other European states when they face substantial integration difficulties.The existing fruitful collaboration among the Network’s partners through existing research networks such as the EC acknowledged network of excellence IMISCOE has evidenced the capacity and added value to pool the talent to the benefit of a common critical mass and enhancement of the academic knowledge. INTEGRIM aims to enhance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Improving therapy of NPM1-mutated AML', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Acute myeloid leukemia (AML) is the most common acute leukemia in adults accounting for approximately 15,000 new cases/year in Europe and 20,000 new cases/year in US. Currently, 40-50% of AML patients (age 18-60 years) and only 5-10% of older patients (who are usually more frequently affected by the disease) can be cured using conventional chemotherapy +/- allogeneic hematopoietic stem cell transplantation. Thus, AML still remains an urgent medical need which calls for new forms of molecular targeted therapies (similarly to those available for acute promyelocytic leukemia). The P.I. previously discovered the nucleophosmin (NPM1) mutations, the most common genetic lesion in AML (about one-third of cases) and gave fundamental contributions in the translation of this seminal discovery into the clinic (improved classification of myeloid neoplasms according to WHO, genetic-based risk- stratification of AML patients, monitoring of minimal residual disease and first demonstration of the anti-leukemic activity of actinomycin D). The present research proposal is focused on improving therapy of NPM1-mutated AML. Specifically, it is aimed to: i) identify novel chemical tools interfering with NPM1 functions by interacting with the N-terminal portion of the protein (objective 1); ii) conduct a clinical trial (AML-PG02; Eudract 2014-003490-41) with actinomycin D in older untreated and/or unfit patients with NPM1-mutated AML and to better understand in vitro and in mice models the mechanisms of action of this drug, used alone or in combination with other agents (objective 2); iii) develop compound mouse models aimed to investigate how NPM1 mutations cooperate with FLT3-ITD or DNMT3A mutations in promoting AML with the goal to better understand the characteristics of relapsed cases and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'CYBERnetic CARS for a new transportation system in the cities' to be submitted under Fifth Framework.

assistant: **Abstract**

Europe leads the development of new transportation systems, based on small-automated vehicles for people or freight delivery in cities, with door-to-door, on-demand service. Several European companies are now proposing to cities and private organisations, transportation systems based on a new generation of cybernetic vehicles, that is vehicles which can run autonomously without a driver on city streets at low speed (up to 30 km/h at the moment), while avoiding fixed and mobile obstacles. The main goal of the Project is to accelerate the penetration of these transportation systems in European cities with the final goal of making life in these cities more pleasant while preserving the freedom to move efficiently and safely. These systems are addressed to everyone, including young and elderly people, and anyone needing some motorized transportation for door-to-door trips at anytime. The objectives of the Project are to improve and integrate the key technologies for the vehicles and for the infrastructure of automated road transportation systems.Objectives:The Project main goal is to accelerate the development and implementation of novel urban transportation systems, based on automated vehicles for movement of people and goods. These systems aim at improving the mobility, while reducing negative effects of the private car use in cities (congestion, pollution), by complementing today's mass transit systems and hence offering a real alternative with better convenience and efficiency than the private car in the cities. The main characteristics of these systems are the use of small electric automated vehicles, which run on the existing urban infrastructure but with a limitation in the number of private vehicles in speed and access. These vehicles will be made available on deman
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'CHOLESTERIC MATERIALS BASED ON POLYMER GELS' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Liquid crystalline materials can be used to manufacture passive or active optical components. Especially the formation of passive optical components by photopolymerization of nematic liquid crystalline (LC diacrylates, and active optical components by photopolymerization of mixtures of nematic liquid crystals and nematic liquid crystalline (LC) diacrylates, the so called anisotropic gels, has been investigate thoroughly within Philips Research. As an extension of this work, it is worthwhile to investigate whether it is possible to make gels with the aid of cholesteric liquid crystals. These materials reflect a band of visible light. In such a way switchable mirrors can be made. In order to broaden the reflection band of these switchable mirrors, one has to establish a gradient in the molecular helix over the cross-section of the gel-layer. This will be tried with the aid of photodegradation of the chiral components of the gel. Also other photochemical processes such as patternwise photopolymerization and holographic techniques, will be used to make components based on nematic and mainly cholesteric polymers and gels. Training content (objective, benefit and expected impact) Dr. Brehmer will receive training in the synthesis of reactive liquid crystals, photopolymerization, electro-optical experiments and application of optical components made from liquid crystalline materials. Electronic products increasingly include optical and electro-optical systems. The components to be developed by Dr. Brehmer will be of importance for the development of new electronic products within Philips. Links with industry / industrial relevance (22) Philips research has very close contacts with the development departments of the product divisions within the Philips company. During the train
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Analysis of AP-1 activation in T cells; new targets against T cell leukemias' (PKCLEUKEMOGENESIS).

assistant: **Concept**

Two critical events propel tumor cells and their progeny into uncontrolled expansion and invasion:<p>deregulated cell proliferation and suppression of apoptosis. The most critical issue is to identify how tumor cells<p>differ from normal cells and how those differences can be exploited therapeutically. Suppression of apoptosis is<p>one of the attributes of cancer cells, and proteins involved in survival pathways can be used as targets of<p>chemotherapeutic drugs.<p>During the past years my colleagues and me have extensively worked with two proteins that play an<p>essential role in T cell proliferation and apoptosis: Vav and Protein Kinase C 6 (PKC6). These two proteins are<p>essential components of the intracellular signaling pathway that leads from TCR engagement to interleukin 2<p>(IL-2) production, the essential marker of T cell activation. An essential component of this pathway is activating<p>protein -1 (AP-1), a transcription factor that binds to the IL-2 promoter. There is evidence supporting an<p>autocrine loop involving IL-2 and IL-2 receptor a (IL-2R d) that is constitutively expressed by the malignant<p>cells in an array of T cell leukemias. In this context, IL-2 gene regulation by AP-1 could be of therapeutical<p>interest. Besides the importance of AP-1 in T cell signaling, most of the intracellular pathway leading to its<p>activation is unknown. We propose to use Vav/PKC0 as a starting point to look for downstream signaling<p>pathways leading to AP-1 activation, with particular emphasis on MAPK cascades. In addition, we propose to<p>identify the components of AP-1 in TCR-activated T cells, using this as well to characterize the upstream<p>pathways that converge on this transcriptional regulator. We propose to dissect this pathway with the idea of<p>developi