RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Chromatin and antigenic variation: The role of histone H1 in gene regulation in African trypanosomes' under Seventh Framework.

assistant: **Concept**

Trypanosoma brucei is a unicellular parasite that causes African sleeping sickness, a fatal disease in humans. There is no vaccine and drugs are very scarce and toxic. T. brucei evades the host immune system by periodically changing its dense, uniform coat of variant surface glycoproteins (VSGs), a mechanism knows as antigenic variation. There are hundreds of VSG genes in the genome, but only one is transcriptionally active at a time. I recently observed major structural differences between the chromatin of active and silent VSGs, with the active VSG essentially being devoid of regularly spaced nucleosomes. The factors involved in establishing and maintaining such disparate chromatin conformations remain unknown. In other eukaryotes, much has been learned about the role of canonical histones in gene regulation, but the role of the linker histone H1 remains elusive. Here I propose to characterize histone H1 in T. brucei, specifically investigating its role in VSG regulation. T. brucei has six different H1 isotypes, which can be grouped into three classes based on their N-terminal sequences. Each class will be epitope-tagged so that their nuclear localization can be compared and the genome-wide distribution of each class can be determined. RNA interference will be used to deplete either all or class-specific H1 and the phenotypes will be examined in two ways: by testing the effects on overall chromatin organization and by testing the specific effects on the VSG gene family, including transcriptional regulation, chromatin structure and switching. Finally, bulk or individual H1 proteins will be purified in order to map the post-translational modifications of H1, and amino acid mutagenesis will subsequently be used to test the role(s) of a subset of these modifications. In t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Diffusion de l'offre d'education sur le marche du travail - effets nationaux et regionaux a travers une comparaison Franco-Espagnole'.

assistant: **Concept**

The tertiarisation of the economy, advances in new technologies and transformations in the organisation of work represent a challenge for governments. They have been able to anticipate public education policy to these changes. Our goals is to summarize the actively advanced ideas, findings and difficulties in the examination of the relation between education policies and labor market in two countries of European Community: France and Spain.  The theoretical framework is provided by the human capital theory (Becker, Mincer...) and the literature about over-education (Sicherman, Groot, Verdugo and Verdugo, Rumberger...). The different papers about over-education use two methods to justify over or under-education: the return rate of education and the matching between actual schooling level and job requirements (Sicherman). Our analysis approaches the second issue. The particularity of our approach comes from the study of the evolution of schooling level and experience (approximated by the age) of all the labor force during the last decade.  The first part of our empirical approach focuses on the explanation of the evolution of the labor force by age, job, and schooling level in France and Spain with data analysis methods and RAS model. We can separate the effect of public education policy (institutional increase of the schooling level) and labor demand effect. The first results of our research team show that the effect of public education policy is very high in France and it is greater than the labor demand effect resulting from firms and technology. Moreover, between 1982 and 1990, the results are very amazing: if we omit the effect of the institutional growth of schooling: the level of schooling decreases for the qualified workers and increases for the unqualified worker
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'RestPoll: Restoring Pollinator habitats across European agricultural landscapes based on multi-actor participatory approaches' (RestPoll) under Horizon Europe.

assistant: **Objectives**

RestPoll is a highly transdisciplinary project aiming to provide society with tools to reverse wild pollinator declines and to position Europe as a global leader in pollinator restoration. RestPoll will, together with stakeholders ranging from individual land managers to governments, co-design, evaluate, and refine measures and cross-sectoral approaches to restore pollinators and their services. The RestPoll consortium combines the expertise of natural and social scientists, NGOs, businesses, and ministries. Stakeholders along the food value chain will be engaged through newly developed participatory approaches at diverse social, ecological, and political scales. Central to RestPoll is the establishment of a Europe-wide network of pollinator restoration case-study areas and Living Labs (LL), which are unique hubs for experimentation, demonstration, and mutual learning.RestPoll aims to position Europe as a global leader and set the future agenda for pollinator restoration worldwide. The transdisciplinary RestPoll consortium will develop, test, evaluate and refine cross-sectoral pollinator restoration approaches to conserve biodiversity and to benefit nature and society. To restore wild pollinator diversity and their vital pollination services, RestPoll will co-design measures with different stakeholders (ranging from individual land managers to governments) at various spatial scales (field, farm, landscape, European scales), in agricultural landscapes that are dominated by intensively managed crops or grasslands. Our holistic approach, informed by cutting-edge transdisciplinary research, will integrate stakeholders and actors at multiple levels as well as natural and social science disciplines to engage in participatory planning and development of new business models. Le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The eye as a window to the brain' (NeuroRetina), addressing dissemination and exploitation.

assistant: **Impact**

Nocturne GmbH, founded in 2018, is a spin-off from the Charité – Universitätsmedizin Berlin, Germany developing software solutions to efficiently process retina image data for neurological applications at scale across devices using advanced AI-based analysis. The innovative and unique technology developed tackles one the current major challenges in healthcare, the rapidly increasing burden of brain diseases. With the increase of life expectancy and aging population neurological disorders are the leading cause of disability and the second leading cause of death worldwide. The greatest unmet needs are better, faster and more cost-effective diagnostic and monitoring tools that could be widely available and have the potential to detect these diseases at the earliest stage in order to delay disability and provide each patient with a personalized treatment.To address this the team of Nocturne identified two major opportunities, the use of the retina as a window to the brain, and an already established on the market hardware imaging technology, cost-effective, widely available with no burden for the patient that can capture retinal images in less than 5 minutes.With its product, Nocturne addresses customers in pharmaceutical research, academia, and clinical care. In Germany alone, more than 1 million patients suffer from relevant diseases like Multiple Sclerosis, Parkinson’s disease, and others. We estimate the annual market volume in Germany alone at 350 million€, in Europe at 2 billion€. At market entry, Nocturne product is a CE-certified local installable web service, which accepts data from standard retinal imaging devices. The data are then analyzed with Nocturne’s technology, and a report is generated for the physician. The pricing is based on a pay-per-analysis, a model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MOrocco and the EU: strengthening BIlateral Links in Innovation and Science for Economy' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The EU and Morocco are fully engaged in a strong and deepen cooperation supported by a high level policy dialogue, and pertaining to multiple sectors including research and innovation. At the institutional level, the Association agreement (1996), the S&T agreement (2003), the European neighboring policy (2004), The new ‘advanced status’ and the program called “To succeed the advanced status” has put emphasis on the consolidation of scientific and technological ties, and are supported by relevant implementation mechanisms and instruments. In May 2011, an institutional twinning program is launched to strengthen and bring closer the Moroccan research and innovation system to ERA. Morocco is highly devoted to reinforce and intensify the current bilateral initiatives and programs in the field of science and technology, aiming to the preparation and definition of joint activities targeting thematics of mutual interest, to improve oriented industry based on S&T cooperation between EU and Morocco, to set up joint collaboration and networking of technical platforms and research laboratories.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Towards a circular degrowth economy: Explaining the material valorization regime of city-regions' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

A transition towards a degrowth economy is necessary to tackle the related challenges of resource scarcity and waste accumulation. Degrowth pursues socio-economic wealth while reducing material flows and reusing waste in socially responsible and ecologically regenerative ways. As a concrete approach to realizing these ends, the concept of the circular economy has gathered political momentum. However, this model will have no impact on city-regions' ecological footprint unless it challenges the regulations that dismiss certain materials as waste in the first place. DECYCLE lays the groundwork for studying the regulatory frameworks that make it possible to revalue waste materials as a resource for city-regional development. It develops an approach termed 'institutional urban political ecology', which combines city-regions' regulatory, spatial, and ecological dimensions, usually studied separately. It interrogates the legal, spatial, and economic regulations that define waste streams' political responsibilities, geographies, and financial architecture. DECYCLE puts forward a new concept, the material valorization regime, to explain how these regulations govern the valorization of waste across multiple scales. It develops a distinct new method of 'enactment tracing' for critical urban research, which involves mapping actors engaged in defending and contesting regulations. DECYCLE comparatively analyzes how regulations valorize streams of construction, food, and heat waste in Hamburg, Amsterdam, Barcelona, Vienna, and Milan. It also explains how transnational regulatory frameworks affect waste reduction at the city-regional scale. By theorizing the relationship between regulatory change and the urban metabolism in contemporary eco-capitalism, DECYCLE sets out to free urbaniza
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Single Chain Nanoparticles as SImplified Models of Intrinsically Disordered Proteins in CompLex CoAceRvates' (SIMILAR).

assistant: **Concept**

The study of intrinsically disordered proteins (IDPs) in cellular environments is complicated by their complex structures and dynamics, leading to challenges in understanding the role of topology in crowded media. Single-chain nanoparticles (SCNPs) have emerged as simplified synthetic models of IDPs, allowing researchers to explore structural and dynamical behaviors without the interference of molecular interactions. Recent advancements in SCNP synthesis methods for biopolymers and polyelectrolytes present new opportunities to study topological effects in complex phases such as polyelectrolyte complex (PEC) coacervates, which are vital for understanding phase separation in intracellular membraneless organelles. The objective of this research is to use model polypeptide SCNPs to elucidate the effects of their topology on the structure and dynamics of PEC coacervates. We hypothesize that the self-coiled structures of SCNPs influence the stoichiometric distribution of polyion charges, thereby affecting the phase behavior and dynamics of PEC coacervates. Our specific aims include: (1) the synthesis and characterization of polyelectrolyte SCNPs with varying morphologies, (2) investigating the impact of SCNP topology on the local structure of PEC coacervates, and (3) exploring dynamic signatures associated with topologically distinct coacervate structures. Utilizing state-of-the-art techniques such as small-angle neutron scattering, wide-angle X-ray scattering, and neutron spin echo, this project aims to advance our understanding of the topological effects in coacervation and contribute to the broader knowledge of phase behavior in both synthetic and biological systems.


**Keywords:** Single chain nanoparticles, coacervation, polyelectrolyte complex, neutron scattering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'TWINSHIP – INTEGRATED DIGITAL TWIN FRAMEWORK TO ENABLE GREEN SHIP OPERATIONS TOWARDS ZERO EMISSION VESSELS', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The TwinShip consortium is spearheading an initiative to transform the maritime sector by creating an alliance of premier maritime technology, solution & service providers, ship design and shipping firms, classification societies, ports, software developers, and research and academic bodies. This collaboration is centered around a unique, open-source digital platform enriched with data and powered by domain knowledge-based advanced machine learning and artificial intelligence capabilities. By introducing a Digital Twin (DT) enabled Decision Support System (DSS) in the same digital platform, TwinShip is setting a course for the maritime industry's rapid digital and environmental transformation. The project sets ambitious benchmarks for reducing Greenhouse Gas emissions in international shipping, aiming for a 30-40% reduction by 2030, 80-90% by 2040, and achieving net-zero emissions by 2045, all relative to 2008 levels by utilizing its Pilot Vessels and Futuristic Unmanned Vessel Concept. This initiative focuses on leveraging both existing and emergent clean fuels and technologies, prioritizing renewable energy sources, and the implementation of unmanned vessels. The TwinShip DT-enabled DSS is crafted to navigate the industry toward achieving these significant environmental targets, demonstrating the consortium's dedication to fostering sustainability and pushing the boundaries of innovation.


**Keywords:** Maritime, Shipping, Energy Efficiency, Emission Reduction, Digital Twin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Computational Fluid Dynamics Aided Design of the Propulsion and Locomotion Systems of a Bioinspired Robot Octopus' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The CFD-OctoProp project aims to investigate the fluid mechanics involved with the propulsion and locomotion systems of cephalopods by means of computational fluid dynamics (CFD) tools. The development of an accurate kinematic and fluid dynamics model of the propelling apparatus of these soft-bodied organisms is intended to aid in the design of an actuator which will eventually be implemented in an octopus-inspired robot. The primary focus of the research project will be the development of a series of numerical models capable of dealing with the fluid-structure interactions (FSI) which arise during the displacement of the robot in water. The CFD analysis will try and derive the most suitable shape and elastic characteristic of the siphon which is best suited for generating thrust in order to propel the robot octopus. Secondly, the incorporation of a kinematic model of the crawling octopus in a CFD code will be perfomed in order to provide the essential background on the techniques adopted by the octopus for optimizing its own motion through water. The final goal of this project is to support in the development of an underwater robot capable of unprecedented motion skills for application in environmental monitoring.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Can immune system rejuvenation restore age-related memory loss?', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

With increased life expectancy, there has been a critical growth in the portion of the population that suffers from age-related cognitive decline and dementia. Attempts are therefore being made to find ways to slow brain-aging processes; successful therapies would have a significant impact on the quality of life of individuals, and decrease healthcare expenditures. Aging of the immune system has never been suggested as a factor in memory loss.  My group formulated the concept of  protective autoimmunity , suggesting a linkage between immunity and self-maintenance in the context of the brain in health and disease. Recently, we showed that T lymphocytes recognizing brain-self antigens have a pivotal role in maintaining hippocampal plasticity, as manifested by reduced neurogenesis and impaired cognitive abilities in T-cell deficient mice. Taken together, our novel observations that T cell immunity contributes to hippocampal plasticity, and the fact that T cell immunity decreases with progressive aging  create the basis for the present proposal.  We will focus on the following questions: (a) Which aspects of cognition are supported by the immune system- learning, memory or both;  (b) whether aging of the immune system is sufficient to induce aging of the brain; (c) whether activation of the immune system is sufficient to reverse age-related cognitive decline; (d) the mechanism underlying the effect of peripheral immunity on brain cognition; and (e) potential therapeutic implications of our findings. Our preliminary results demonstrate that the immune system contributes to spatial memory, and that imposing an immune deficiency is sufficient to cause a reversible memory deficit. These findings give strong reason for optimism that memory loss in the elderly is preventable and