RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Mechanical Basis of Genome Organisation through INO80'.

assistant: **Innovation**

Recent breakthroughs found that mechanical features of gene promoters influence nucleosome positioning through ATP-dependent chromatin remodeling enzymes. This finding challenges classical models of DNA-sequence-dependent histone recruitment. While mechanisms for the translation of DNA’s physical parameters to nucleosome positions are debated, their experimental validation is still pending. MebaGINO aims to address this fundamental gap in knowledge. Taking advantage of recent advances in time-resolved CryoEM, I will answer the following research question:What is the biophysical mechanism underlying the influence of DNA mechanics on nucleosome positioning by INO80?I will use the INO80 chromatin remodeler as a model system to understand how nucleosomes are positioned adjacent to gene promoters featuring specific mechanical patterns. Firstly, I will interrogate how the nucleosome translocation process will be stalled through substitution of ATP with ATP-analogues on DNA with varying stiffness. From these experiments, I will obtain molecular structures via single-particle CryoEM. Next, I will obtain molecular structures from short-lived states using time-resolved CryoEM. For this, I will contribute to the development of an automated platform for CryoEM sample freezing which will be made available to the scientific community via EMBL's Electron Microscopy facility. Finally, I will build a biophysical model explaining the influence of DNA mechanics on INO80’s translocation process. Thus, I will provide novel views onto the mechanical basis of gene regulation which are relevant beyond fundamental research as for example during cancer development.During this project, I will receive extensive training on cutting-edge structural biology instrumentation while contributing with my
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Hypothalamic mechanisms of thermal homeostasis and adaptation'.

assistant: **Innovation**

Mammalian organisms possess the remarkable ability to maintain internal body temperature (Tcore) within a narrow range close to 37°C despite wide environmental temperature variations. The brain’s neural “thermostat” is made up by central circuits in the hypothalamic preoptic area (POA), which orchestrate peripheral thermoregulatory responses to maintain Tcore. Thermogenesis requires metabolic fuel, suggesting intricate connections between the thermoregulatory centre and hypothalamic circuits controlling energy balance. How the POA detects and integrates temperature and metabolic information to achieve thermal balance is largely unknown. A major question is whether this circuitry could be harnessed therapeutically to treat obesity. We have recently identified the first known molecular temperature sensor in thermoregulatory neurons of the POA, transient receptor potential melastatin 2 (TRPM2), a thermo-sensitive ion channel. I aim to use TRPM2 as a molecular marker to gain access to and probe the function of thermoregulatory neurons in vivo. I propose a multidisciplinary approach, combining local, in vivo POA temperature stimulation with optogenetic circuit-mapping to uncover the molecular and cellular logic of the hypothalamic thermoregulatory centre and to assess its medical potential to counteract metabolic syndrome. Acclimation is a beneficial adaptive process that fortifies thermal responses upon environmental temperature challenges. Thermoregulatory neuron plasticity is thought to mediate acclimation. Conversely, maladaptive thermoregulatory changes affect obesity. The cell-type-specific neuronal plasticity mechanisms underlying these changes within the POA, however, are unknown. Using ex-vivo slice electrophysiology and in vivo imaging, I propose to characterize ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'High throughput analysis of the in vivo metabolite/protein interactome in plants'.

assistant: **Concept**

In the last decade, new technologies have emerged to study protein-protein and protein-nucleic acid interactions under near-physiological conditions at large scale. In contrast, development of similar performing technologies for screening and discovery of in vivo metabolite/protein interactions has received little attention. Nonetheless, metabolites comprise a large and important fraction of the cellular molecules. Many can bind proteins as substrates, products, cofactors, and ligands, and thereby constitute metabolic networks or regulate a myriad of environmental and developmental responses, often at very low concentrations. Here, we will establish a performing method for the discovery of novel in vivo protein-metabolite interactions in the model plant Arabidopsis thaliana by adapting an available high throughput protein affinity purification/mass spectrometry platform used for detecting protein-protein interactions. Receptor proteins involved in jasmonate signalling will be used as the model systems to discover new metabolites that interact in vivo with proteins. Ultimately, the role of the identified metabolites and the relevance of their molecular interactions for the jasmonate signalling cascades that steer growth and metabolism will be investigated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Woodoo Augmented Wood - transforming wood into construction material strong as concrete and translucent as amber'.

assistant: **Objectives**

Woodoo transforms natural wood into an augmented material that is strong, light, durable and stunningly translucent. It uses a patented scalable technology to replace wood’s lignin with a bio-polymer that boosts its performance. The result is a material as strong as concrete and luminous as amber. It will be used to create unique auto interiors, lightweight car chassis and sustainable wooden buildings. It will benefit Europe by revitalising the forestry sector. Problem: Global shortage of construction materials (concrete, steel), even as the urbanisation boom exacerbates demand. Current building materials are unsustainable. Wood is too weak to replace steel and concrete. Solution: Woodoo creates augmented wood, a new material that is abundant, sustainable and extremely strong. Woodoo wood can be bent into any shape, used like touchscreens for electronics, and replace concrete to build massive wooden constructions with low environmental footprint. Innovation: Wood is treated to remove lignin, then impregnated with a proprietary polymer. This modifies wood’s structure, increasing strength and durability, while allowing light to penetrate. Commercialization: Woodoo will produce small batches for auto suppliers for interior panels and wooden touchscreens. It will later license technology to carmakers and sawmills to enable large-scale localized production. Demand: Interest from major premium car manufacturers and tier 1 suppliers. Markets: Auto outfitting, construction materials, lignin by-product. All large and growing. TAM of €125B for the automotive interior materials and €313B for wood construction. Company: Founded in 2016. Team of experienced managers and R&D experts. Ready to scale. Project: Woodoo will develop an auto interior part (a dashboard) from augmented wood.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'AutoMatic and Personalized Mental HealthCare Solution' to be submitted under Horizon 2020.

assistant: **Abstract**

The need: There are over 1,100 million people who have a mental disorder worldwide1, of which 268 million suffer1 from depression and 800,000 people yearly die from suicide2. According to WHO, mental illnesses are the leading causes of disability-adjusted life years worldwide3, and depression accounts for one third of this disability4. In 2010, the global cost of mental illness was estimated at nearly $2.5 trillion (two-thirds in indirect costs) with a projected increase to over $6 trillion by 2030.5 In spite of these figures, treatments for mental disorder work and suicide attempts are partly preventable if doctors and caregivers monitor the treated patient mental health progression adequately.6 However, the healthcare and treatment of psychiatric patients are still inefficient because there is a lack of systems providing real-time information of the patient.Our solution: In response, we have developed MindCare, a mHealth solution that addresses the current lack of a real-time heath status monitoring for mental disorder patients. MindCare is a smartphone Apps (Fig. 1) that: 1) passively gathers data through a wearable device about the patient; 2) transforms the data into interpretable information using Artificial Intelligence (AI) for doctors, patients and caregivers; and, 3) integrates and displays the patient information, providing personalized information so that doctors and caregivers can quickly change the patient treatment or intervene at the right time.As a result, MindCare facilitates diagnostics, improves the quality of care, accelerates recovery, saving costs of treatments (€340,000 to €6.3 million/year), lowers the days of hospitalizations (~20%), and empowers psychiatric patients for a better self-management.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The competitiveness of firms, regions and industries in the knowledge-based economy: What room for job-rich growth in Europe?' (MICRO-DYN).

assistant: **Innovation**

MICRO-DYN (stands for 'Micro-Dynamics') is a project that attempts to tackle the issue of growth, employment and competitiveness in the knowledge-based European economy through a micro-founded firm-based approach. The nature of the analysis will be 'bottom-up' i.e. moving from the micro-entities of economic actions and strategies at the enterprise level to sectoral, regional, national and European levels.The rationale for such an approach is that understanding the microeconomic foundations of innovation, competitiveness and growth at the firm level, as well as the firms' interactions with the labour market, is key to understanding the nature of these phenomena at a more aggregated (regional, sectoral or macro) level and of the resulting aggregate economic performance. From a policy-perspective, this implies that the impact of corporate, industrial and regional strategies and policies at national and European levels can be really understood only through the changes they induce in individual firm behaviour.Integrated and comparable cross-country firm-level evidence will shape the core of the research effort undertaken within the project. The analysis will use as far as possible comprehensive data-sets across all European regions and industries. Statistical models of individual behaviour will be used which will be aggregated at sectoral, regional and national levels to recover the behaviour of aggregate variables.At the moment, there are very few such models around as different researchers have concentrated on different levels of aggregation with little exploration of their interdependence. The project mobilises a large network of top European researchers specialized in the relevant sub-fields necessary for the successful execution of an ambitious research programme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Growth balance regulation by SnRK1 under ABA-stress conditions' (ABA-GrowthBalance) under Horizon 2020.

assistant: **Objectives**

In response to adverse environmental conditions, such as water scarcity, extreme temperatures or salinity plants trigger responses that promote stress tolerance and survival at the expense of growth. Despite the negative impact of stress on crop productivity how growth is modified by stress signalling pathways is largely unknown. One major component of the response to the most devastating stresses is ABA, a hormone that triggers cellular and whole-plant adaptive mechanisms via the activation of SnRK2 protein kinases. Another major player is the energy sensing SnRK1 protein kinase, which promotes plant stress tolerance and survival through the vast regulation of metabolism and gene expression. Preliminary results in the host lab have revealed deficient ABA responses in a partial SnRK1 loss-of-function mutant as well as the physical interaction between SnRK1 and the ABA-activated SnRK2 kinases, suggesting a functional connection between these two pathways. Furthermore, SnRK1 and SnRK2 have recently been implicated in the repression of a central growth regulator, the TOR (Target of Rapamycin) protein kinase. The aim of this proposal is to investigate the interaction between these two major stress-related kinases (SnRK1 and SnRK2) and to elucidate the mechanism(s) by which they modulate growth-promoting signalling pathways in response to ABA. To tackle the functional relevance of the SnRK1-SnRK2 connection, a combination of biochemical approaches, genetics, microscopy, cell-based assays and chemical genomics will be used. To identify growth regulators downstream of the SnRK axis, targeted analyses of TOR readouts will be employed in combination with unbiased analyses of SnRK1 interactors and substrates in ABA. Altogether this project will provide novel molecular insight on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'A Coordination Action for Soft Robotics'.

assistant: **Concept**

Soft robotics, intended here as the use of soft materials in robotics, is a young research field, going to overcome the basic assumptions of conventional rigid robotics and its solid theories and techniques, developed over the last 50 years. Overcoming these assumptions raises the risks related to the poor applicability of known robotics theories and techniques, as well as the risks related to the development of new theories and techniques, for solving problems with unknown solutions or which may be ill-posed. Using soft materials to apply forces on the environment, as expected in a soft robot able to locomote, grasp, and perform other tasks, poses new problems at the level of the different components as well as at the whole system level. The technologies for actuating the soft materials have not yet been demonstrated to exist in a general form, although specific effective examples exists. The same is true for sensors embedded in the soft materials and for soft robotic energy suppliers. This high risk is counter-balanced by a very high potential impact. Soft robotics has the potential for allowing the development of a radically new generation of machines with better performance. Even though research in this field is growing world-wide, as witnessed by the increasing number of papers, special sessions and workshops, the community of soft robotics is still scattered. Robotics journals and conferences do not host it adequately. This results from the difference in the expertise required and developed in conventional rigid robotics and in soft robotics.A Coordination Action for Soft Robotics is extremely necessary and timely in the current and future landscape of robotics and biorobotics and can capitalize on the competitiveness of European research in this new field. A comm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Next-generation control system to enhance performance of commercial fishing trawlers'.

assistant: **Concept**

Trawl fishing is one of the most common commercial fishing techniques in the world. Large nets are towed behind a boat and catch massive amounts of fish before being pulled onto the vessel. However, this technique has major drawbacks for those companies using it: as the movement of the nets is extremely difficult to control, captains are required to drastically change the vessels movement and continuously adjust winch control knobs to accommodate the nets position. Thus, they cannot focus efforts on guiding ships, and as a result, there is a waste of fuel in unnecessary, inefficient manoeuvres, and damage to the equipment, which requires constant maintenance. Moreover, the poor ability to control trawl placement also has a negative impact on the environment, as the nets catch unwanted fish or disturb the ecosystems, (e.g. when trawl nets touch the ocean floor as controls do not adjust to maintain a specific depth). Hence, there is a global need for better tools to control trawl nets and vessels in an efficient manner. We, Naust Marine ehf, count with 24 years of experience in the design and development of winch and trawl control systems for fishing vessels. Our latest development is Smart Trawling, an intelligent control platform that will help address the problems of current trawlers. Smart Trawling utilizes 18 data inputs from the trawl net, vessel, and winches to automatically adjust the nets and vessel to the optimum operating conditions. In this way, with the automated control of Smart Trawling, vessels run more efficiently, without wasting time or fuel compensating for missing the targeted fish or fighting ocean currents: Iceland’s Ministry of Environment determined a 15% reduction of fuel consumption for vessels using Smart Trawling. Additionally, trawling equipm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Sustainable Energy Investing and Financing Activation'.

assistant: **Concept**

The project of the Sustainable Energy Investing and Financing Activation (SEIFA) will create incentives to increase private equity investing for the industrial decarbonisation of the built environment. The SEIFA project is focusing on investing and financing of deep renovation industrial projects, energy supply facilities and energy service companies. The investors-first approach will be held with an emphasis on the environmental impact in terms of decarbonisation rate and risk-adjusted rate of return. The new financial schemes to incentivise private individual and institutional investments to sustainable energy projects will be established. Innovative financing schemes will include sustainable energy investing risks metrics and benefits. The network of regional/national project aggregators will be established. Investment pooling and proposed investment vehicles will let achieve lower transaction costs. The financial software tools will be provided for the energy efficiency measurement, quantification and evaluation of additional benefits of sustainable energy investing including decarbonisation rate, increased asset value, impact on investor reputation, and for investment rating and ranking. The detailed methodology of the sustainable energy investment securitisation and detailed roadmap for the secondary market for sustainable energy investing will be created. Initial milestones of the secondary market for sustainable energy investing will be accomplished during the project duration. The planned project duration is 30 months. At least 500 million Eur for sustainable energy projects will be provided during the SEIFA project duration and it is expected that 5 billion Eur mark will be reached during the 5 years after the project completion. The SEIFA project platform wil