RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Advancing knowledge to improve outcome in Paget’s disease of bone'.

assistant: **Concept**

Paget’s disease of bone (PDB) is a common skeletal disorder in people of European descent characterised by abnormal bone remodeling which disrupts normal bone structure causing pain, deformity, nerve compression syndromes and fractures. The causes of PDB are incompletely understood. Genetic factors play a key role and some predisposing genes been identified but many remain to be discovered as do the mechanisms by which these genes influence bone cell function. Environmental factors also contribute but these are poorly defined, and it remains unclear how genes and environment interact to regulate susceptibility and severity.  Further research is required to permit earlier diagnosis and to define the genetic and environmental factors that influence susceptibility to PDB so that new therapeutic strategies can be developed to improve outcome.The Paget-Advance programme will progress beyond state-of-the-art by identifying new genetic variants that predispose to PDB by extended genome wide association studies and next generation sequencing of early onset familial cases where the causal genes are unknown. A genetic profiling test will be developed to facilitate early diagnosis and treatment. The functional mechanisms by which the variants affect bone cell function will be investigated using bioinformatics, cell culture studies and preclinical disease models. Potential environmental triggers will be explored focusing on the intestinal microbiome diet and biomechanical loading using preclinical disease models and prospective clinical studies.  The result will be to increase understanding of PDB and to facilitate earlier diagnosis and timely therapeutic intervention which will improve clinical outcome for patients and those at risk of the disease. The research will also have wide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Photo-excited State Dynamics and Non-equilibrium States under Laser in Van der Waals Stacked Two-dimensional Materials'.

assistant: **Innovation**

The project of “PeSD-NeSL” is a fundamental and scientific project that will be carried out by Dr. Jin Zhang under the supervision of Prof. Angel Rubio. Dr. Zhang is a theoretical scientist with extensive experience and good publication records in the field of laser-excited carrier and structural dynamics. Prof. Rubio is the managing director of the Theory Department of MPSD and one of the leading experts in fields of ab initio calculations of electron excitations and dynamics in Physics, Chemistry, and Biophysics. This project will also involve collaborations with top international experimental and theoretical groups.The proposed project “PeSD-NeSL” is focusing on the non-equilibrium states and dynamics under laser in van der Waals (vdW) stacked materials, including carrier multiplications, light-induced Moiré engineering, interlayer Moiré exciton, light-induced insulator-metal phase transition among others. The intriguing processes provide a strong motivation for studying microscopic details of optical responses in vdW materials upon laser excitation. The underneath microscopic interactions among photon, electron, exciton, phonon and other quasi-particles are crucial and far from being clearly understood as they relate to the macroscopic quantum phenomena. We will perform state-of-the-art numerical experiments in three parts: Part 1. Carrier multiplications in two-dimensional monolayers and vdW heterostructures; Part 2. Light-induced Moiré engineering and Moiré excitons in vdW bilayers; Part 3. Photoinduced phase dynamics and non-equilibrium states in TMD layers. We aim to establish a clear relationship between microscopic interactions and macroscopic quantum phenomena in low-dimensional materials under field perturbations. The success of “PeSD-NeSL” will consolidate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Bee Ethic Frames 2.0 a disruptive technology in Apiculture' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

The main objective of this innovation is to provide a durable and sustainable solution to the Varroa Destructor, a bees’ mite which – in the past 30 years – has spread all around the world contributing to the well-known Colony Collapse Disorder (CCD) which has resulted in a drastic economic and ecological damage to beekeeping and pollination.For the first time, The Bee Ethic Frames consist of an electronic resistor which is heated by an electricity flow managed through a control unit. Research conducted with the Universities of Perugia and Torino has demonstrated the high efficacy of the system, which has also proved to be safe both for bees and bee-keepers. The system kills adult Varroas but also infants which transmit viruses to the bees (an important research by Torino University is showing that the use of the system lowers virology in the bee family). This system does not generate any chemical residues, unlike the alternative chemical treatments currently in use. Since 2013, the Bee Ethic system is protected by a patent, which have been registered under PCT in 2015. Extension has been obtained in the main world markets. The Bee Ethic Frames have been sold in the Italian market for the past three years to the satisfaction of our customers. However, their market penetration has been slowed down by two factors: 1) high price compared to alternative solutions; 2) poor user-friendliness of the system. A new and highly innovative generation of thermic frames, the Bee Ethic Frames 2.0, are currently being prototyped to address these issues. By incorporating a micro-control unit within each frame, it will be possible to reduce costs drastically and to improve considerably the ease-of-use of the system. These improvements will open up significant market opportunities, enabli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'It takes two to TAngO2: unravelling the role of syntrophic interactions in the evolution of anaerobic eukaryotes' under Horizon Europe.

assistant: **Concept**

Living without oxygen is challenging. To live in low-oxygen environments, some microbes exchange nutrients allowing for a division of labor among individuals in a process called ‘syntrophy’. Such interactions are often a pre-requisite for prokaryotes living in these environments. Whether syntrophy is necessary for the survival of microbial eukaryotes (protists) is unexplored and yet, critically important to discerning the roles of eukaryotes in nature and how eukaryotic cells adapt to live without oxygen.TAngO2 will test the hypothesis that syntrophic partnerships allow eukaryotes to thrive in anaerobic environments and underpin the evolution of key eukaryotic cell biological characteristics. This will be accomplished using state-of-the-art genomic, computational, and experimental approaches.I will discover genes essential for interactions between a model protist and its ectosymbiont using massively-parallelized transposon mutagenesis. This will discern the molecular mechanisms, metabolic interplay, and selective forces dictating eukaryote:prokaryote interactions.I will deliver metagenomes of cultured anaerobic eukaryote:prokaryote consortia predicted to be engaging in syntrophic interactions. This will drastically expand our knowledge of the biodiversity of eukaryotic genomes and microbial interactions from low-oxygen environments. I will interrogate the frequency and diversity of syntrophy in eukaryotes by simultaneously sequencing the genomes and transcriptomes ofindividual protist cells and their microbiota sampled from nature. This will provide the first elucidation of what communities co-exist with natural anaerobic protists.Understanding how syntrophic interactions have influenced eukaryotic cell biology will reveal hidden connections in the complicated functiona
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ADvanced Validation of A Novel TB Active disease diagnostic to address Global unmet needs: a European consortium approach' (ADVANTAGE).

assistant: **Concept**

Tuberculosis (TB) remains an EU and global healthcare priority resulting in over 1.4 million deaths each year. Despite this and efforts to reduce TB by the EU commission, the WHO and others, a simple, rapid, diagnostic test for active tuberculosis (TB) remains elusive. Current diagnostic procedures, while accounting for over $1 bn globally, are poorly selective for active TB, hold risks for healthcare personnel, are slow to yield results and costly. The large potential and high unmet need provide a clear target for commercialisation of a point-of-care (POC) test. Using over 400 clinical samples, ProteinLogic (a UK based diagnostics company) have demonstrated proof of concept for a ground-breaking approach using a panel of protein biomarkers on human serum samples that profile the cell mediated patient response to TB. The objectives of the eight structured work packages within this three year project are to build on the validation of the biomarker TB panel transitioning from a laboratory assay to Biosensia’s novel microfluidic POC platform that has already been successfully proven with a variety of human analytes. Reagents will be developed as part of this project to ensure reduced costs and security of commercial supply. A unique instrument reader plus TB cartridge-based product will be developed to meet EU regulatory standards. The products will be validated in order to confirm analytical and clinical performance, and to provide evidence of major time, cost & performance improvements compared to current TB testing practises. Successful commercialisation will lead to the creation of  over 30 new jobs and will stimulate further private investment in each of the companies. In summary, ADVANTAGE has the potential to deliver a disruptive POC TB diagnostic test that can help
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Extended degrees of freedom in QFT' (EXTENDED) targeting Horizon Europe.

assistant: **Abstract**

Quantum field theory (QFT) is the formalism that underlies modern particle and condensed matter physics. Standard perturbative methods in QFT have been extraordinarily successful in explaining physical phenomena involving weakly-interacting quantum fields. On the other hand many fundamental phenomena, including phase transitions and nuclear interactions, are described by strongly coupled QFTs for which perturbative techniques are insufficient and a rigorous, predictive theoretical formulation is lacking. Heuristic arguments indicate that a full non-perturbative formulation of QFT must include extended degrees of freedom (a prototypical example being the flux tubes that bind quarks inside the nucleus).My proposal describes a novel approach for studying extended objects in a wide range of QFTs, based on two recent conceptual breakthroughs: first, my research on a special class of theories (the six-dimensional SCFTs) has brought to light a rich algebraic structure that captures the properties of its stringlike excitations; and second, new developments in mathematics and physics point to the existence of a vast generalization of this structure, which is perfectly suited to describe the extended objects of a much wider range of QFTs.This program is organized along three directions: analyze the families of QFTs that can be studied by string-theoretic and geometric methods, and gradually uncover the algebraic structures that describe their extended degrees of freedom; exploit these algebraic structures to obtain novel principles that govern the dynamics of strongly-interacting QFTs; and determine the new mathematical structures that arise from the combination of the geometric and algebraic description of the extended objects.An ERC starting grant will allow me to undertake thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '6th european international conference on biocatalysis and biotransformations' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

- Highly interdisciplinary and stimulating European biocatalysts forum for intense scientific education and exchange within and beyond the 5th FP. - (i) Acceleration of the development cycles for bio-processes and a rapid vertical knowledge transfer. (ii) Engagement of young scientists both from EU and CEEC into a research network. (iii) Integration of scientists from CEEC and third countries and industrial representatives into existing and new EU networks; integration into COST D25.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Floodplain biodiversity and restauration 2: integrated natural science and socio-economic approaches to catchment flow management'.

assistant: **Innovation**

Problems to be solvedThis proposal seeks to contribute to enhancement of the ecological quality of riparian ecosystems in Europe through the development of water allocation guidelines. It will achieve this by combining expertise in the natural and social sciences to investigate the flow needs of riparian species, floodplain vegetation impacts on water levels, and institutional structures for decision making in river basin flow management.Scientific objectives and approachThe research involves four linked objectives:Objective l: To develop scientific guidelines for the application of river flow prescriptions which benefit floodplain ecosystems while maintaining acceptable levels of flood control.Objective 2: To quantify aspects of the relationships between hydrological inputs to a floodplain and plant response measured in terms of water consumption, growth and the diversity of regeneration strategies.Objective 3: To investigate the flow resistance associated with woody riparian vegetation using field studies and mathematical modelling.Objective 4: To investigate and compare the effectiveness of selected institutional arrangements for restoring floodplain environments at different spatial scales and in different national/local settings.Expected impactsIt is expected that the research will contribute to the development of water management practices that are sensitive to the ecological needs of riparian ecosystems. This will be assisted by the production of a manual of best practice based on natural science information. Some of this information will be generated within the project. In addition, the project will assess the institutional capacity to resolve problems of environmental degradation (particularly in floodplain environments), while respecting the diverse demands on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The European Biodiversity Partnership' (Biodiversa-plus).

assistant: **Concept**

Being one of the main actions of the EU Biodiversity Strategy 2030, the European Biodiversity Partnership (Biodiversa+) will coordinate research programmes between EU and its Member States and Associated Countries, mobilising environmental authorities as key partners for implementing biodiversity research and innovation, along with ministries of research, funding organisations, and environmental protection agencies (75 organisations from 37 countries). Biodiversa+ has five overarching objectives: (1) improve monitoring of biodiversity and ecosystem services across Europe (status and trends); (2) generate actionable knowledge to tackle the direct and indirect drivers of biodiversity loss; (3) expand and improve the evidence base, and accelerate the development and wide deployment of NbS to meet societal challenges across Europe; (4) make the business case for the conservation and restoration of biodiversity; and (5) ensure efficient science-based support for biodiversity policy making in Europe. Biodiversa+ will meet these objectives by (i) setting up a pan-European network of harmonized monitoring schemes, building on existing national/regional monitoring schemes, creating capacity for setting up new schemes, and feeding into the EC Knowledge Center for Biodiversity; (ii) coordinating research programmes between the EU and its Member States and associated countries, thereby ensuring the long-term pan-European research agenda is co-created and implemented; (iii) contributing science-based methodologies to account for and possibly value ecosystem services and the natural capital, and to assess the dependency and impact of businesses on biodiversity and (iv) better linking of R&I programmes to the policy arena, providing greater input to policy making and improving the ass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Joining the forces of Natural Killer Cells and Ferroptosis to treat Refractory Neuroblastoma' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Neuroblastoma (NB), a rare paediatric solid tumour, accounts for 15% of childhood cancer deaths. Immunotherapy has improved the survival for haematological malignancies, but solid tumours remain a challenge. The high heterogeneity, low mutational load, and strong immunosuppressive tumour microenvironment (i-TME) have hindered the success of immunotherapy in NB. Recently, natural killer (NK) cells have stood as a promising immunotherapeutic tool, as they don’t depend on specific mutations. Still, clinical trials for NB show only modest results, proving further action is needed to overcome the iTME. Late findings show that refractory tumours often respond to Ferroptosis, a novel cell death mechanism that is highly immunogenic. Cancer cells undergoing ferroptosis release HMGB1 and other well-known recruiters of NK cells. Moreover, ferroptotic drugs can act through several mechanisms and can be adapted to patients with different tumour characteristics. The goal of IronKiller is to combine ferroptotic drugs with NK cell therapy to treat refractory NB, and to perform in silico modelling of the results to predict which patients would benefit from this novel therapy.I am an experienced biologist and engineer joining a clinical research group strong in immunotherapies. We will follow an in vitro-in vivo-in silico strategy that will cover a variety of disciplines, from basic biology and pre-clinical research, all the way to bioinformatics and machine learning. I will reinforce my experience in cell death mechanisms and translational research, and I will also acquire new knowledge and skills in the areas of cell immunotherapy and oncological mathematical modelling. The latter through a secondment at an academic institution. Along with the research work, the diverse training, manag