RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Dissecting the chromatin dynamics at telomeres during mouse pre-implantation development.' (TeloChromatin), addressing dissemination and exploitation.

assistant: **Impact**

In the last decades, the progress in medicine have contributed to extend human lifespan considerably. Unfortunately, this aging of populations gives rise to the increased appearance of degenerative diseases and cancers, and therefore represents a critical problem for public health. During embryonic development, cellular proliferation is an essential process that is required to generate all the tissues and organs that contribute to the adult organism. However, alterations in the molecular mechanisms regulating this fundamental process can drive developmental defects and tumors. Cellular fail-safe systems evolved to prevent these events to happen. One of them is the natural shortening of chromosome ends, termed the telomeres. This “molecular clock” prevents cells from proliferating if their telomeres become critically short, which could lead to chromosomal alterations. This mechanism is responsible for cellular aging in Human. Unfortunately, cancer cells can bypass this process through the activation of telomere maintenance mechanism allowing for virtually unlimited proliferation. Interestingly, such maintenance mechanisms naturally occur during early embryonic development. The proposed research is aimed at understanding how telomeres are regulated in this system and under a physiological context. My expertise in mouse embryonic work associated with the competences in telomere biology of the host laboratory of Dr. Jerome Déjardin will likely be a suitable combination to answer these questions. On the long term, these researches could lead to the discovery of key factors regulating telomere maintenance. Finally, as the suppression of telomere length maintenance inhibits cell growth, the present proposal could contribute to the development of new treatments against cancer o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'EVALUATING THE IMPACT OF STRUCTURAL POLICIES ON HEALTH INEQUALITIES AND THEIR SOCIAL DETERMINANTS AND FOSTERING CHANGE' (SOPHIE).

assistant: **Concept**

The need to deal with health inequalities is now on the agenda of key supranational institutions, such as the European Commission (EC). To tackle the so-called “causes of the causes of health inequity”, the focus should be put on structural policies, policies that – especially in the current times of financial and employment crisis – influence patterns of social stratification, living and working conditions, and thus people's health. The SOPHIE project aims to generate new evidence on the impact and effectiveness of structural policies in reducing health inequalities, and to develop innovative methodologies for the evaluation of these policies in Europe.We will study major policy areas, including macro-economy, welfare state, labour market and employment relations, built environment, housing, as well as gender-oriented and immigration-related policies. Examples of these policies at the European, national and local levels will be examined, in addition to their impacts on health inequalities by social class, gender and migrant status.  The project will develop theoretical frameworks as well as quantitative and qualitative methods for evaluating the effectiveness of such policies in different contexts. Novel methods that are useful for evaluating the impact of complex social interventions will be employed, including realist reviews, explanatory case studies and concept mapping. Particular attention will be given to increasing the involvement of affected stakeholders (civil society and deprived population groups) in the identification, design and evaluation of policies to tackle health inequalities. Affected communities and stakeholders will work with responsible policymakers in activities of dissemination of results, knowledge transfer and translation of findings into poli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Preparation of a european network for renewable energy hybrid power systems (PREHYNET)' (PREHYNET), addressing dissemination and exploitation.

assistant: **Impact**

This measure has the aim to prepare a European network for hybrid power systems that contain renewable energy generators. The scope of the activities will embrace small, medium and large island power supplies (1 kW some 100 MW). The broad application of such hybrid concepts requires a lot of agreements on the technological level including aspects like power quality, safety, interfaces, communication and control. Experts from the involved disciplines have to be identified in order to prepare an effective network.Committees which are able to prepare appropriate European standards have to be established. Activities from different countries will be harmonised and actual European projects will be exploited in order to strengthen the competitiveness of the involved European industries and to enable especially SMEs and companies of less favoured regions to contribute to a well-defined technology with future prospects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'High performance hydrophobic suberin nanoparticles for the generation of liquid-air biphasic droplets with application in food and therapeutics', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

An antibubble is a droplet of liquid with a shell surrounded by a thin film of gas. Antibubbles have many potential applications, e.g. drug delivery with application in a clinical setting and the food industry. The major challenge is to develop antibubbles with a long life time; essential for industry usage. The gas shell can be stabilized using hydrophobic nanoparticles to create a particle shell surrounding the air. The use of particles, instead of surfactants, to stabilize dispersed systems is an attractive sustainable solution for the food industry. Our demonstration of the ionic liquid-catalyzed purification of the polyester suberin - from plant materials in the form of hydrophobic nanoparticles led us to investigate their potential application for the generation of high performance antibubbles.


**Keywords:** Plant polyesters,  suberin,  hydrophobic nanoparticles,  Pickering,  antibubbles,  food grade ingredients
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'on-Demand System Reliability' (DeSyRe) under Seventh Framework.

assistant: **Objectives**

DeSyRe will perform research on the design of future reliable Systems-on-Chip (SoCs). These are systems that guarantee continuous and correct operation in the existence of different types of faults. It is a well known fact that various systems are extremely sensitive to faults. Typical examples are medical (i.e. implantable cardiac pacemakers) or automotive systems (i.e. vehicle stability control), in which the shortest stop in operation will cause dramatic damages. Therefore, such applications require a fault-tolerant system, which guarantees correct and reliable functioning at any time.However, as semiconductor technology scales, chips are becoming ever less reliable; prominent reasons for this phenomenon are the sheer number of transistors on a given silicon area and their shrinking device features. As a consequence, fault tolerance, e.g. provided through various redundancy schemes, has an enormously increasing power and performance cost. To make matters worse, power-density is becoming a significant limiting factor for performance and SoC design in general. In the face of such changes in the technological landscape, current solutions for fault-tolerance are expected to introduce an excessive overhead in future SoCs. Attempting to design and manufacture a totally fault-free system, would impact heavily, even prohibitively, the design, manufacturing, and testing costs, as well as the performance and power consumption of a system.DeSyRe will build new, more efficient, adaptive fault-tolerant SoCs delivering a new generation of by design, on-demand reliable systems. Compared to existing approaches, the DeSyRe objective is to reduce the power and performance overheads of fault-tolerance by 10-20%, as well as to improve yield by decreasing the number of defective chips by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Comic Motifs in Romances of Chivalry of Spanish Golden Age' (CoMoRoC), addressing dissemination and exploitation.

assistant: **Impact**

Romances of chivalry are one of the most representative literary genres of Spanish Golden Age,which gained great popularity in XVI century. In the last few years, critical studies have stressed theimportance of the uniformity of this corpus, which includes many imitations, sequels, and prequels resumingthe threads of the narration where they were dropped. The main consequence is that the genre involves agreat deal of stereotyping of the same situations, contexts, even episodes, which became common motifs andrecognizable formulas for the readers. The fictitious biography of a knight-errant, a Christian prince whoestablishes his heroic credentials, finding love and power, is only the basic thread of a structure whichpresents a reiterative pattern where themes and motifs are usually combined in the same fashion. A motif isthe smallest narrative unit of a tale, that shows persistence in the tradition, where it survived with a specificidentity, and can be included in different contexts; it is a recurrent unit with a fixed narrative or descriptivecontent; generally, it concerns a specific episode or accident: the main action is consistent in everymanifestation of the motif, but details can (and do) change. The main focus of this proposal is the analysisand categorisation of comic motifs (jokes and pranks) in the corpus of chivalric novels, starting from its mostfamous cycles. The research is also meant to study poetic and literary treatises of XVI-XVII centuries, todevelop a reflection on the value, function and meaning of comic expression at the time. The comic elementsof the genre will be then compared to the parody of the romances of chivalry realised by Cervantes in DonQuixote. This research will consolidate the general paradigm of the genre, studying its morphology; thec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Oil and herbicide pollution in the Black Sea : detection and biological impact'.

assistant: **Objectives**

Foreseen ResultsThe data collected on the pollution in the monitored areas will be correlated with the population distribution and physiological state of benthic/interstitial organisms that represent in this project the response of the biota to pollution induced stress. The biological impact will be studied largely as a cooperative Ukrainian : Israeli effort.The proposed research is focused on the North and North-West sectors of the Black Sea and on the deltas of the three major Black Sea tributaries : Danube, Dnieper, Dniester. 150 sampling stations are planned. Two types of pollutants are selected for monitoring : oils representing industry/transportation of produced pollutants and herbicides representing pollutants originating from the agricultural sector. Potential of total pollutants contained in the water to generate biological damage will be assessed in the laboratory by unspecific, highly sensitive algal bioassay and in the Sea by monitoring response of benthic organisms.It is proposed to develop novel low-cost techniques for detection of oil and herbicide pollution. The feasibility of the novel techniques will be assessed in the laboratory and subsequently in the field conditions by comparing them with conventional analytical methods. The techniques will be developed as a cooperative effort of Czech and French research teams and of a small Czech business. Testing of the novel techniques will on the cooperation with Ukrainian and Israeli teams. Conventional analytical methods will be used by the Ukrainian proposers to provide standardized information about composition and spatial distribution of the pollutants.In parallel to the highly specific conventional and novel analytical methods, unspecific bioassays will be used to estimate the biological impact of the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fern diversity of malaysia - systematics of selected genera of the brake family - pteridaceae' to be submitted under Fourth Framework.

assistant: **Abstract**

Malaysia is one of the global hotspots of biodiversity, especially ferns: ca. 1/3 of the world's fern species occur in the region. One of the most species rich groups is the family Pteridaceae (approx. 250 species), well known for its horticultural representatives. The aim of the present project is to revise two subfamilies Taenitidoideae and Cheilanthoideae (with approx. 15 genera in total). This will be done by extensive analyses of the morphology, and especially comparative studies of anatomical and sporangium structures. The resulting data base will be used to establish a phylogenetic classification of the family. The taxonomic results will contribute to the international Flora Malesiana project, which aims at a full inventory of the flora; including identification tools and multimedia presentations. The reconstructed phylogeny will greatly enhance our understanding of the evolution of this ancient fern group. Field work is required to collect material as well as to capture ecological and morphological variation essential for species delimination.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'REGULATING STAFF ENHANCEMENT IN ORGANISATIONS (GLASNOST)' (GLASNOST).

assistant: **Innovation**

My project aims to assess the impact of human enhancement technologies used at work onto employees and their performance. Indeed, the use of human enhancement technologies in organisations can shape the fu-ture of work, i.e. how one performs at work, how one feels at work, how one relates to others and managers. It has implications in terms of employee well-being and health. My project will promote the consideration of ethical issues in the implementation of technologies used to enhance the performance of individual employ-ees in organizations. It will first look at how organisations and stakeholders consider ethics in the way they implement the use of enhancement technologies, and then it will consider the role of ethics in shaping em-ployee acceptance and experience of the technology. Based on these elements, I will design together with stakeholders guidelines for the implementation of human enhancement in the workplace and a policy brief. The nature of this project is grounded in Ethics and Information Systems Management (IS), while being poli-cy-driven. Mixing these skills will provide an innovative look on theories of acceptance in IS, a field that traditionally understands ethics as ‘privacy’. Holding a PhD in IS and a master’s degree in Political Sciences, I have expertise in investigating organisations, policy, as well as users’ perception of technology. However, I need to get training in Ethics in order to integrate the forms of ethical assessment and dimensions of ethics to the IS theory. I will complete this research while hosted at the Philosophy Department of the University of Twente (UT) and supervised by Prof. Philip Brey, which will allow me to grow expertise in applied ethics and ethics of technology, and through a 6 month secondment in Dublin City Univ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The importance of Nef effects on HIV-1 infectivity for viral pathogenesis' in the context of a Seventh Framework call.

assistant: **Objectives**

The AIDS epidemic remains a worldwide emergency and the molecular mechanisms leading to the disease are not fully understood. Nef is a gene product of primate lentiviruses crucial for virus replication in vivo and for AIDS progression. The mechanisms supporting its pathogenic role remain undefined. Among other activities, Nef enhances intrinsic virus infectivity, a feature well conserved and under selective pressure during disease progression. While the significance of this activity in vivo is unknown, a recent finding from the applicant (Pizzato M. et al, PNAS, 104, 2007) shows that it requires the interaction of Nef with the cellular GTPase dynamin 2. In addition, preliminary results show that glycogag, encoded by gamma-retroviruses, exerts a similar enhancing activity on HIV infectivity, suggesting that this is a fundamental property of unrelated retroviruses. The aim of the research is to establish in vivo the role of the Nef-induced enhancement of HIV-1 infectivity, and to evaluate the importance of the interaction with dynamin 2. A recently developed humanized mouse will be used as model of HIV infection in vivo. Because Nef exerts several functions, the specific role of the enhancement of infectivity will be studied by separating this from other activities, following four objectives: 1) To establish in vivo the phenotype of HIV-1 carrying Nef mutations which selectively impair specific activities. 2) To study the requirement of Nef in vivo using a CD4-independent HIV whose infectivity cannot be affected by the Nef-induced CD4 downregulation activity. 3) To assess the role of glycogag-induced enhancement of infectivity for HIV replication and pathogenesis in vivo. 4) To study the importance in vivo of the Nef surface interacting with dynamin 2. This research will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'COSMOlogy BEyond Standard Techniques: a program to exploit cosmic voids for precision cosmology' (COSMOBEST) targeting Horizon Europe.

assistant: **Abstract**

Cosmology addresses the fundamental questions about our Universe: what is it made of? how does it evolve? Observations suggest that the Universe is undergoing an accelerated expansion---to explain it, cosmologists hypothesize the existence of a mysterious component: dark energy. Despite major recent advances in the field, up to now traditional methods in cosmological analysis have failed to provide a throughout understanding of dark energy. Large-scale surveys, mapping the distribution of billions of galaxies in the Universe, allow us to look back in time and encompass the era when dark energy rises: they are a powerful tool to address our fundamental questions. The next generation of surveys, and in particular the ESA Euclid mission, will map the Universe with high-quality measurements reaching unprecedented precision; they will sample the galaxy distribution in detail also in the emptier regions with fewer galaxies: voids. Void cosmology is in its golden age, and constitutes nowadays an increasingly active sector of galaxy clustering analysis: by measuring void properties we obtain stringent constraints on cosmological parameters. Voids allow to perform a novel and independent analysis of large-scale structure data, bringing us in the regime of COSMOlogy BEyond Standard Techniques. Voids are extremely sensitive to the properties of dark energy and neutrinos, and are a powerful tool to test general relativity in a new regime. COSMOBEST is an ambitious ERC program aiming to exploit voids as a novel and robust tool to shed light on the puzzles of modern cosmology. It capitalizes on the PI's wide experience in building void science in large collaborations, with a strong focus on calibration-free techniques and systematics control. With COSMOBEST I will lead void analysis