RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'THE ROLE OF ECOLOGICAL COMPETITION IN THE EVOLUTION OF ANIMAL SIGNALS'.

assistant: **Innovation**

Species interactions are known to play an important role in community ecology but their influence on phenotypic evolution is not well understood. Where closely related species come into contact they could diverge, converge, or competitively exclude each other. This project will examine the importance of the level of phenotypic and genetic similarity of species in determining patterns of phenotypic variation at contact zones. In particular, the project will focus on variation in traits important in social interactions and how these may diverge or converge between species based on the intensity of resource competition. It will incorporate geographic variation across the landscape and the importance of environmental variation between populations. Bird songs are known to play an important role in territorial interactions, and this study will focus on how the level of ecological and genetic similarity influences the extent of divergence or convergence in songs of Hypocnemis antbirds. Because of the importance of bird song in species recognition, variation in the direction of displacement is of fundamental importance to our understanding of the processes that explain evolutionary diversification. Furthermore, an understanding of how the extent of phenotypic similarity and ecological competition affects the level of range overlap that occurs between species at different contact zones may aid in better understanding current species distributions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploiting eXascale Technology with Reconfigurable Architectures' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

To handle the stringent performance requirements of future exascale High Performance Computing (HPC) applications, HPC systems need ultra-efficient heterogeneous compute nodes. To reduce power and increase performance, such compute nodes will require reconfiguration as an intrinsic feature, so that specific HPC application features can be optimally accelerated at all times, even if they regularly change over time. In the EXTRA project, we create a new and flexible exploration platform for developing reconfigurable architectures, design tools and HPC applications with run-time reconfiguration built-in from the start. The idea is to enable the efficient co-design and joint optimization of architecture, tools, applications, and reconfiguration technology in order to prepare for the necessary HPC hardware nodes of the future.The project EXTRA covers the complete chain from architecture up to the application:• More coarse-grain reconfigurable architectures that allow reconfiguration on higher functionality levels and therefore provide much faster reconfiguration than at the bit level.• The development of just-in time synthesis tools that are optimized for fast (but still efficient) re-synthesis of application phases to new, specialized implementations through reconfiguration.• The optimization of applications that maximally exploit reconfiguration.• Suggestions for improvements to reconfigurable technologies to enable the proposed reconfiguration of the architectures.In conclusion, EXTRA focuses on the fundamental building blocks for run-time reconfigurable exascale HPC systems: new reconfigurable architectures with very low reconfiguration overhead, new tools that truly take reconfiguration as a design concept, and applications that are tuned to maximally exploit run-time r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Molecular mechanism of separase dependent PP2ACdc55 downregulation' to be submitted under Seventh Framework.

assistant: **Abstract**

Activation of the protease separase at anaphase onset leads to cleavage of cohesin, thereby triggering chromosome segragation. At the same time, an essential protease-independent function of separase promotes cell cycle progression out of mitosis. In the host laboratory it has been recently shown that separase interacts with the Cdc55 isoform of protein phosphatase 2A (PP2ACdc55) at anaphase onset, downregulating it (Queralt et al. 2006). However, the molecular nature of this non-proteolytic activity of separase and how it mediates PP2ACdc55 downregulation is still unknown. In this research project we propose to address the molecular mechanism by which separase downregulates PP2ACdc55 at anaphase onset.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Center of Excellence in Advanced Pharmaceutical Technologies' (ExcellPharmTech) under Horizon Europe.

assistant: **Objectives**

Masaryk University (MU) is the second-largest university in the Czech Republic located in Brno. Thanks to the ESIF funding, MU was able to acquire top research infrastructure attracting talented researchers who gradually built the position of the MU as the top regional hub for education, research, and innovation.To further exploit this potential, the management structures and processes of the university must thoroughly implement the European Research Area (ERA) Priorities. As an outstanding researcher/innovator can have a decisive and positive impact on the culture and performance of any institution, MU will recruit a world-class research manager as an ERA Chair for its newly-established Faculty of Pharmacy.The Faculty of Pharmacy (MUNI Pharm) is, besides others, focused on the development of advanced drug formulations and molecular biology techniques. The ERA Chair will intensify the research and development of advanced drug formulation and nanotechnologies to open new opportunities to intensify MUNI Pharm research capacities in the field of pharmacy and develop strategic partnerships with the application sphere and public sector for faster translation of the advanced drugs into clinics.The recruitment of leading scientist will enforce the connection of the MUNI Pharm to research structures of MU, and the ERA Chair will make a bridge in the formation of unique education and research facility at one place titled MUNI BioPharma Hub, supported from National Recovery Plan (part of RRF  Recovery and Resilience Facility, NextGeneration EU).To solve the targeted delivery and transportation of nucleic acids into target cell environment, the MUNI Pharm will establish an interdisciplinary center of excellence (Pharma Center of Excellence in Advanced Technology) with prof. David
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Genomic Modifiers of Inherited Aortapathy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Thoracic aortic aneurysm and dissection (TAAD) is an important cause of morbidity and mortality in the western world. As 20% of all affected individuals have a positive family history, the genetic contribution to the development of TAAD is significant. Over the last decade dozens of genes were identified underlying syndromic and non-syndromic forms of TAAD. Although mutations in these disease culprits do not yet explain all cases, their identification and functional characterization were essential in deciphering three key aortic aneurysm/dissection patho-mechanisms: disturbed extracellular matrix homeostasis, dysregulated TGFbeta signaling and altered aortic smooth muscle cell contractility. Owing to the recent advent of next-generation sequencing technologies, I anticipate that the identification of additional genetic TAAD causes will remain quite straightforward in the coming years. Importantly, in many syndromic and non-syndromic families, significant non-penetrance and both inter- and intra-familial clinical variation are observed. So, although the primary genetic underlying mutation is identical in all these family members, the clinical spectrum varies widely from completely asymptomatic to sudden death due to aortic dissection at young age. The precise mechanisms underlying this variability remain largely elusive. Consequently, a better understanding of the functional effects of the primary mutation is highly needed and the identification of genetic variation that modifies these effects is becoming increasingly important. In this project, I carefully selected four different innovative strategies to discover mother nature’s own modifying capabilities in human and mouse aortopathy. The identification of these genetic modifiers will advance the knowledge significantl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Eurosceptic Populist Party Organization and Representation: A Comparative Study' (POPREP).

assistant: **Concept**

This proposal can be summed up under the following two headings 'Project' and 'Training'. While separate here for clarity, the conduct and success of each is essentially intertwined with - and dependent on - the other:(1) PROJECT: The project analyzes party organization and representation in six Eurosceptic populist parties: the Northern League (Italy), Sinn Féin (Ireland), the Swiss People's Party (Switzerland), Front National (France), the Danish People's Party (Denmark) and the Socialist Party (Netherlands). No comparative indepth study of this type, depth and breadth currently exists. The approach taken is conceptually innovative, methodologically interdisciplinary and theoretically ambitious. It answers calls for empirical research on populism by scholars and by the European Union itself (Work Programme, 2010). The research aims to provide the first comparative empirical study to date of Eurosceptic populist organization and representation, in a monograph with a top international publishing house, thus helping me achieve a leading independent academic position and an international profile as a key comparative European politics scholar.(2) TRAINING: Given the ambitions both of this project and my own career goals, high quality training in applied interdisciplinary methods, data analysis and project management are all essential prerequisites. With advice and support from renowned scholars and colleagues at the EUI, the overall aim of this fellowship is to build on my prior research career, but take it now to a far greater level of comparative and theoretical breadth, sophistication and originality thanks to the quality of mentorship, training and international research environment offered by the EUI. Through the skills acquired - and applied in the project - I will m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Breaching the boundaries of safety and intelligence in autonomous systems with risk-based rationality' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Autonomous systems able to comprehensively assess and model risks would be a scientific breakthrough leading to highly intelligent system behaviors, safe interactions in unstructured environments, and public trust. Currently, risk perception is an important part of human cognition not adequately implemented in the situation awareness, control and decision-making of autonomous systems. Therefore, this project addresses fundamental research challenges related to risk-based autonomy and safe and efficient shared control with human supervisors. The aim is to develop powerful risk modelling and built-in risk control solutions, closely connected to risk-based decision support for human supervisors in-the-loop. The outcomes of the project will allow for new, safe, and advanced types of transport, mapping and monitoring of oceans and land, and inspections of structures difficult to access. Although there are a few preliminary concepts coupling risk models with control algorithms and artificial intelligence (AI), a fundamental framework providing risk-based control and decision support – for both the autonomous system and human supervisors – does not exist. In BREACH, I will establish such a framework constituted by quantitative risk models merged with data-driven approaches, simulation and model-based approaches, integrating hardware, software, human, and environmental risk elements. The complexity of the framework will gradually evolve in two parallel tracks along with demonstrations for mission planning and execution for autonomous marine “organizations”. The focus on marine systems is due to the demanding challenges in that domain, and my knowledge and experience as a researcher in the Centre of Excellence on Autonomous Marine Operations and Systems (NTNU AMOS). For several
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Drivers and consequences of coevolution in protective symbiosis'.

assistant: **Concept**

All organisms in nature are targets for parasite attack. Over a century ago, it was first observed that symbiotic species living in hosts can provide a strong barrier against infection, beyond the host’s own defence responses. We now know that ‘protective’ microbial symbiont species are key components of plant, animal, and human microbiota, shaping host health in the face of parasite infection. I have shown that microbes can evolve within days to protect, providing the possibility that microbe-mediated defences can take-over from hosts in fighting with parasites over evolutionary time. This new discovery of an evolvable microbe-mediated defence challenges our fundamental understanding of the host-parasite relationship. Here, I will use a novel nematode-microbe interaction, an experimental evolution approach, and assays of phenotypic and genomic changes (the latter using state-of-the-art sequencing and CRISPR-Cas9 technologies) to generate new insights into the drivers and consequences of coevolving protective symbioses.  Specifically, the objectives are to test: (i) the ability of microbe-mediated protection to evolve more rapidly than host-encoded resistance, (ii) the impacts of evolvable protective microbes on host-parasite coevolution, and the effect of community complexity, in the form of (iii) parasite and (iv) within-host microbial heterogeneity, in shaping host-protective microbe coevolution from scratch. Together, these objectives will generate a new, synthetic understanding of how protective symbioses evolve and influence host resistance and parasite infectivity, with far-reaching implications for tackling coevolution in communities.


**Keywords:** experimental evolution, coevolutionary biology, parasitism, mutualism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Zooming in on the core-mantle boundary' (ZoomDeep) targeting Horizon 2020.

assistant: **Abstract**

The core-mantle boundary (CMB) is the interface between the liquid iron core and the silicate solid mantle, and is the most significant internal boundary of the Earth. The core and the mantle interact across the boundary through transfer of heat and material, and various coupling mechanisms. While the nature and variability of these interactions remains uncertain, they strongly affect the convection in the mantle, responsible for plate tectonics and intra-plate volcanism, as well as the much more vigorous convection in the core, responsible for the geodynamo. Constraining the interactions at the CMB is crucial to understanding physical processes in the deep Earth and the thermal, compositional, and dynamical evolution of the Earth. The CMB interactions are strongly controlled by heterogeneous structures on or near the boundary. On the mantle side, seismological imaging has observed slow velocity layering and patches, but their physical significance remains uncertain, and it is unclear whether they represent global or local features. Turning to the core, suggestions of a stable light-element-enriched layer have been made. The estimated thickness of such a layer varies from 40 to 450 km, and the origin of the inferred light elements is heavily debated. In ZoomDeep, I propose innovative seismic techniques to image the structure near the CMB with unprecedented resolution.  One technique, dubbed 'the Frequency Fan', will be newly developed, while another technique has recently been successfully applied at the Earth's surface and will be adapted to the CMB. ZoomDeep will lead to the first high-resolution maps of the structures near the CMB and will specifically focus on the roots of mantle upwellings beneath volcanic hotspots. The implications of these maps on fundamental que
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Computer aided rehabilitation of sewer networks' under Fifth Framework.

assistant: **Concept**

This project deals with public sewer and storm water networks and their problems caused by ageing such as structural failures, insufficient capacity causing floods, local pollution, and increasing maintenance costs. The ultimate goal is to develop a suite of tools, which provide the most cost-efficient system of maintenance, repair and rehabilitation of sewer networks, with the aim to guarantee a security of sanitary sewage collection and storm water drainage that meets social, health, economic and environmental requirements as well as the re-use of water for consumption.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Asymmetric microenvironments by directed assembly: Control of geometry, topography, surface biochemistry and mechanical properties via a microscale modular design principle' to be submitted under Seventh Framework.

assistant: **Abstract**

The interaction of cells with the extracellular matrix or neighboring cells plays a crucial role in many cellular functions, such as motility, differentiation and controlled cell death. Expanding on pioneering studies on defined 2-D model systems, the role of the currently known determinants (geometry, topography, biochemical functionality and mechanical properties) is currently addressed in more relevant 3-D matrices. However, there is a clear lack in currently available approaches to fabricate well defined microenvironments, which are asymmetric or in which these factors can be varied independently. The central objective of ASMIDIAS is the development of a novel route to asymmetric microenvironments for cell-matrix interaction studies. Inspired by molecular self-assembly on the one hand and guided macroscale assembly on the other hand, directed assembly of highly defined microfabricated building blocks will be exploited to this end. In this modular design approach different building blocks position themselves during assembly on pre-structured surfaces to afford enclosed volumes that are restricted by the walls of the blocks. The project relies on two central elements. For the guided assembly, the balance of attractive and repulsive interactions between the building blocks (and its dependence on the object dimensions) and the structured surface shall be controlled by appropriate surface chemistry and suitable guiding structures. To afford the required functionality, new approaches to (i) topographically structure, (ii) biochemically functionalize and pattern selected sides of the microscale building blocks and (iii) to control their surface elastic properties via surface-attached polymers and hydrogels, will be developed.The resulting unique asymmetric environments wil