RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Transition from sea to land: Olfactory function and adaptations in terrestrial crustaceans' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Within adult anomuran land crabs (Coenobitidae: Anomura) there are various degrees of terrestrialization, but all species have retained marine larval stages. The ability to recognize and discriminate chemical cues in the environment is essential for most animals, and thus a successful transition from sea to land calls for dramatically new demands on the chemosensory system, where stimulus changes from mainly water-soluble molecules to hydrophobic, volatile chemical cues carried by the air. Hence, these land crabs represent an excellent opportunity to investigate the effects of the transition from sea to land on the olfactory system. The olfactory organs of Coenobitidae show structural similarities with the insects, indicating an adaptation for function in air and both field and laboratory studies show that land crabs do make use of their olfactory system on land and seem to have quite sophisticated olfactory abilities for distant chemoreception. Also new neuroanatomical studies indicate that the coenobitids have superb olfactory processing and discrimination capacities.  The main objective of this research project is to explore the seemingly extraordinary olfactory abilities of the Coenobitidae and to understand how they have evolved as adaptations to the terrestrial environment. In a highly interdisciplinary approach, behavioural investigations will be integrated with modern neurophysiological and optical imaging techniques, to identify which chemical substances induce biological activity and to study olfactory processing and discrimination capabilities. The project will generate new knowledge about how environmental and evolutionary forces dictate specific adaptations in olfactory systems, which will contribute to our general understanding of the olfactory sense. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PeptiEUForce: a game-changing ingredient for the pre-diabetic population' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Diabetes is accepted as a global and EU epidemic, with 415 million people suffering type 2 diabetes worldwide. Europe has 60 ml. diabetics, swallowing 13% of the EU healthcare budget, or €290bn. This is before we add the 318 ml. people globally with impaired glucose tolerance (prediabetics). The EU has highlighted functional foods as a valuable solution to prevent diabetes but to date, no advances of any significance have been made in scientifically proven functional food solutions in the diabetes arena. Existing methods for discovering such solutions are ancient and are exceedingly time, resource, and cost heavy. Nuritas Founder, Dr Nora Khaldi disrupts the paradigm using artificial intelligence and DNA analysis to find new disease-beating molecules in natural foodstuffs. She pioneers the field of food bioinformatics where she has won multiple EU competitive grants in her 11-year long academic research career. Recognised as having the potential to grow bigger than Facebook in size, Nuritas boasts the world’s largest peptide database, which along with a unique discovery method has helped find a groundbreaking, scientifically validated and patent-filed peptide molecule. This regulates blood sugar, which is key in the battle with diabetes type 2. Together with the exclusivity of our 20-year patent protection, it will deliver a very significant and on-going partnership with a food/pharma multinational company. Nuritas is expected to generate significant global sales by 2024 with a resultant high delivery on job creation through the development of this peptide. The significant learnings from this project will also be utilised on Nuritas’ consistently expanding portfolio of other novel life-changing molecules. The  European and global socio economic impact will be huge. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Signalling in migrating T lymphocytes' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

T cells have a central role in the bodys immune response to pathogens and other disorders such as in cancer and autoimmune disorders. T cells are constantly moving and this migration involves the interactions of different adhesion molecules such as the integrins. One important member of this family is the integrin LFA-1. When this integrin binds to its ligand ICAM-1, it has an adhesive function but it also has a key role in signalling. The Hogg lab has shown that the binding of LFA-1 to ICAM-1 signals reorganisation of the cytoskeleton and motility in the T cell. In fibroblasts and endothelial cells, the regulation of integrin-containing adhesions is dependent on a Ca2+-requiring cysteine protease called calpain. The Hogg lab has demonstrated that calpain is involved in formation of the LFA-1-mediated adhesions made by T cells and that it has a specific role in the de-adhesion of the migrating T cell. The applicant has evidence that the activation of calpain is dependent on the G protein heterodimer G12/13 an d also on phospholipase C which can give rise to the Ca2+ flux necessary for calpain activity. The aim of the proposed project is to identify the individual signalling pathway members leading from G12/13 to active calpain and, secondly, to understand how they affect T cell migration. Briefly we will identify the downstream elements from G12/13 and we will first investigate the role of GTPase Rho and its major effector Rho kinase and also the role of PLCepsilon. Importantly, we will link these findings to a lteration of T cell migration and look in more detail at specific alteration of LFA-1 adhesions. T cells spend most of their lives either circulating in and out of lymph nodes as naïve cells or, following exposure to antigen, migrating into other tissues. Therefo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Physics Beyond the Standard Model at the LHC and with Atom Interferometers' under Seventh Framework.

assistant: **Concept**

Elementary particle physics is entering a spectacular new era in which experiments at the Large Hadron Collider (LHC) at CERN will soon start probing some of the deepest questions in physics, such as: Why is gravity so weak? Do elementary particles have substructure? What is the origin of mass? Are there new dimensions? Can we produce black holes in the lab? Could there be other universes with different physical laws?  While the LHC pushes the energy frontier, the unprecedented precision of Atom Interferometry, has pointed me to a new tool for fundamental physics. These experiments based on the quantum interference of atoms can test General Relativity on the surface of the Earth, detect gravity waves, and test short-distance gravity, charge quantization, and quantum mechanics with unprecedented precision in the next decade.  This ERC Advanced grant proposal is aimed at setting up a world-leading European center for development of  a deeper theory of  fundamental physics. The next 10 years is the optimal time for such studies to benefit from the wealth of new data that will  emerge from the LHC, astrophysical observations and atom interferometry. This is a once-in-a-generation opportunity for making ground-breaking progress, and will open up many new research horizons.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for '5G ExPerimentation Infrastructure hosting Cloud-nativE Network applications for public proTection and disaster RElief', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

5G is considered to be the next decade mainstream broadband wireless technology and can leverage the efficiency and effectiveness of everyday high demanding operations such as public protection and disaster relief (PPDR). ITU considers LTE-Advanced systems and 5G as a mission critical PPDR technology able to address the needs of mission critical intelligence by supporting mission critical voice, data and video services as an IMT radio interface. 5G-EPICENTRE will deliver an open end-to-end experimentation 5G platform focusing on software solutions that serve the needs of PPDR. The envisioned platform will enable SMEs and developers to acquire knowledge with regard to the latest 5G applications and approaches for first responders and crisis management, as well as to build up and experiment with their solutions. The 5G-EPICENTRE platform will be based on an open Service oriented Architecture, following the current best DevOps practices (containerization of micro-services) and will be able to accommodate and provide open access to 5G networks’ resources, acting this way as a 5G open source repository for PPDR Network Applications. For the assessment of the abovementioned platform, the realization of several use cases is being foreseen which will be realized as a PPDR vertical.  The purpose of the use cases is to expand along the entire range of the 3 ITU-defined service types (i.e. eMBB, mMTC and URLLC) as well as to provide the floor for overseeing the platform’s secure interoperability capabilities beyond vendor-specific implementation. The engaged SMEs and organizations that will participate into the realization of the use cases constitute active players in the public security and disaster management, thus acting as key enablers for the assessment of 5G-EPICENTRE with r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sensor islet organoids (SILORGS) for in vivo identification of anti-diabetic drugs' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

To develop new drugs for treatment of diabetes, there is an immediate need for an in vivo approach allowing the assessment of β-cell function and survival in the living organism non-invasively, longitudinally and at single-cell resolution. We therefore transplant genetically engineered sensor islet organoids into the anterior chamber of the eye of mice for functional microscopic imaging. Using the cornea as a natural body-window, following their engraftment various aspects of β-cell function and survival can be readily imaged in these organoids. Functional studies demonstrate that engrafted islet organoids in the eye respond to the diabetic milieu of diabetic mouse models. We have extensively in vitro tested fluorescent biosensors that reflect key-events in β-cell function and survival. Following intraocular transplantation of mouse and human islet organoids expressing biosensors in their β-cells into healthy or diabetic mice, they will allow non-invasive, longitudinal in vivo monitoring of 1) glucose responsiveness, 2) Ca2+ handling, 3) functional β-cell mass, and 4) proliferation. Based on the in vitro tested biosensors, the major objective is to establish a robust pharma-industry in vivo imaging platform for validating newly developed diabetes treatment lead-compounds in early drug development. This screening service shall be performed on a commercial basis. The milestone of this proposal, to be achieved within 18 months, is the validation of the sensor islet organoid-based in vivo platform for testing the effects of new potential diabetes medicines on human β-cell function and survival in normal and diabetic mice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Fair Pensions and Population Ageing'.

assistant: **Innovation**

Demographic changes in survival rates and age structures require adaptions in public policies. This grant will produce a social benefit by providing policy makers with two kinds of tools that they will need to make these adaptions, fair normal pension ages and consistently up-to-date measures of population ageing that take the changing characteristics of populations into account. An important area of adaption is national pension policy. Recently changes in pension policies have been driven by financial considerations and have aroused a great deal of dissent. One reason for the unhappiness with proposed pension reforms is that they place the burden of reform inequitably. People generally dislike inequitable policies. In this grant, we will produce a detailed case study of equitable pension ages. In the ReAgeing project we dealt with fairness in a very general framework. In this grant, we present an innovative methodology that produces scenarios of equitable normal pension ages using the details of a specific pension system. This grant shows how fairness can enter public policy discussions of ageing.In the future, new problems with respect to population ageing could arise and new data will certainly become available. In the ReAgeing grant, we produced many new measures of population ageing that took the changing characteristics of populations, such as remaining life expectancy and health into account. Our presentations were based on data that were available at the time of writing. In order for the results of the ReAgeing grant to remain relevant requires a second innovation, a way to keep the new measures of population ageing up-to-date. We do this with two pieces of software that can immediately be updated every time the UN produces a new round of data. We cannot predict
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a reliable and cost effective seal to protect glass containers from contamination' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

At the end of the project, the following main results have been achieved:- definition of system requirements and specifications of the beverages and glassware producers;- conceptual design of the PROGLASS system, including the seal tape, the applying and removing modular heads;-numerical analysis of the application system (modal analysis to eliminate possible sources of vibrations) and of removing system (fluodynamic analysis to improve the efficiency of the apparatus);- detailed design of the applying and removing systems;- detailed design of the seal tape considering different kinds of plastics and laminated and co-extruded structures;- manufacturing of the prototype of applying system and removing system;- testing of different plastic films of novel formulation for the envisaged application;- the software tool for the control of the system and the adaptation of PROGLASS to different plant layouts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Agent-based Computational Economics for Policy Analysis' (ACEPOL), addressing dissemination and exploitation.

assistant: **Impact**

The recent economic crisis has also been a crisis for economic theory. Hence, the economic profession started to debate and prepare a methodological reconsideration about the general role of economic models; new modeling strategies, alternative and complementary to the standard Dynamic Stochastic General Equilibrium (DSGE) models, have therefore emerged. Among these innovative approaches, Agent-based Computational Economics (ACE) started to occupy a prominent role. However, ACE models still need to be improved in three main directions before being ready to be employed as a standard policy tool adopted by central banks. These three directions are: (i) calibration, (ii) external validation, (iii) formal evaluation of systemic risk.This fellowship aims at directly tackling these three issues by employing new statistical learning, econometric, and algorithmic techniques and by applying them to an ACE model that enables one to analyze private and public debt dynamics by closely following the financial and real sectors at the micro-level.The research plan here proposed aims at developing a calibrated and validated model able to explain how the rise in private debt and the interconnectedness of financial institutions might lead to financial crisis, which then might spread to the real sector and ask for a massive public sector intervention, possibly generating also public debt overhangs. Additionally, the innovativeness in the methods here employed will allow to establish higher standards for the development of descriptive ACE models. Once these model are properly and rigosously calibrated and validated by means of real-world datasets indeed, they can be adopted to evaluate a set of counterfactual policy exercises. In particular we aim at understanding which ex-ante policy meas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Developing a Non-Invasive Kit for Early Colorectal Cancer Detection' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Colorectal cancer (CRC) represents one of the most important health problems worldwide. Decreasing the mortality rate by CRC in Europe is a clear unmet need today. Medical community agrees that this number of CRC related deaths could be prevented by adequate screening programs for early detection. European authorities look for new strategies to address the clinical need for early diagnosis of CRC that will reduce patient care associated costs. Potential savings would be achieved if CRC patients were diagnosed earlier. The objective of this proposal is to validate and commercialize a novel, non-invasive, simple to use kit (ColoFastTM), regulatory approved for the diagnosis of CRC in blood. It is based on a new generation of leading-edge biomarkers that showed very high sensitivity and specificity for early detection of CRC in two prospective cohorts. The commercialization of the kit will have clear impact in improving survival of patients and reducing mortality by CRC cancer, with significant costsavings for National Health Services. It will be easily implemented in the clinical routine of the majority of European hospitals, with better acceptance of patients. ColoFast represents a significant business opportunity, addressing a clear unmet medical need in a large and expanding target population of 189M people in Europe in 2020, growing at 25%, with a significant global market of €1,616M in Europe, the US and Japan this year. It will have a huge impact on the growth of a SME as Amadix over the next 10 years, multiplying the team size by five in five years (41 employees in 2020). 2M European people will benefit from the test in 2024. Amadix turnover in 2021 will be €18 m, which will give our company a profit of €7 m in 2021. From this year on the company will be profitable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dynamic Personalization of Multimedia' to be submitted under Seventh Framework.

assistant: **Abstract**

MyMedia addresses the key social problem of what has been called the Crisis of Choice", the problem of information overload.  We want to increase the level of relevant content over the "noise". The problem worsens year-by-year as more and more content, including self-created content, becomes available online as well as through traditional broadcast means (delivered through satellite, over-the-air, IPTV, and cable).  This is not a new problem yet it still has not been solved in a way that satisfies end-users. We will address this problem by creating an open source software framework to dynamically personalize the delivery and consumption of multimedia.  MyMedia will tame growing volume of content streams by combining them and allow users to sip from a single manageable stream of the most personally relevant content.The project will pioneer the integration of multiple, content catalogues and recommender algorithms in a single system. The project delivers an open source software framework which allows researchers and potential commercial exploiters outside of the consortium to easily plug-in and experiment with new recommender algorithms and content sources.  This simplifies take-up outside the consortium and creates an even wider impact.  The project will evaluate resulting theoretical user models through a set of lab analysis and field trials.  The framework will also be evaluated on multiple trial platforms and will be language agnostic.  To understand cultural differences field trials will be conducted in multiple countries and languages.  MyMedia will innovate by enabling the creation of media-centric social networks that leverage user generated metadata such as tags and explore other possibilities focused on improving the end user experience such as automatically gen