RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'NON SPECIFIC SEROLOGICAL REACTIONS IN BOVINE BRUCELLOSIS. DEVELOPMENT OF DIAGNOSTIC TOOLS FOR DIFFERENTIATION BETWEEN BRUCELLOSIS AND INFECTION DUE TO YERSINIA ENTEROCOLITICA O:9' under Fourth Framework.

assistant: **Concept**

Background :Bovine brucellosis (BB) has been eradicated in most parts of Northern EU countries but herds must be monitored continously for the potential presence of the disease. An unacceptable prevalence of the infection persists in certain areas of EU member states. A high level of non-specific reactions to serological tests has recently emerged in several countries. Another bacteria, Yersinia enterocolitica O:9 (YO9), seems to be responsible for these cross-reactions. Unnecessary restrictions, waste of resources, genetic losses, failure to control the disease, as well as trade restrictions are some of the consequences of this situation. The objective is :This proposal aims at developing diagnostic tests able to differentiate infection byBrucella abortus (BA) from infection by YO9. Blood tests based either on cellular orhumoral immunity detecting only the anti-BA response as well as tests to detectspecifically infections due to YO9 will be developed. Short description of the project :The project will consist of 7 main tasks: - Development of a bovine gamma-interferon enzyme immunoassay for Brucella; - Development of ELISA tests specific to Brucella; - Development of an indirect ELISA using antigens specific to Yersinia; - Development of immunoaffinity enrichment to improve direct bacteriological isolation of Yersinia; - Development of a polymerase chain reaction-gene probe detection system specific for pathogenic strains of Yersinia; - Experimental infection of cattle; - Field trials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Open Robot Control Software'.

assistant: **Innovation**

OROCOS designs and implements software for robot control, under Open Source license. The goal is to make a library of modular software components that are flexibly useable for all kinds of robotic systems. The major goals are: independence of computer and robot platforms, broad scope (not just industrial robots, but all kinds of mechatronic devices), bottom-up development (implementation of the basic control layers, on top of which larger systems will be built later on).The Open Source nature of the project must allow to reach a critical mass of co-designers and implementors that are not sponsored by the project itself.Objectives:The technological objectives are:- to produce a functional basis for general robot control software,- which is released under an open source software license, i.e., the (L)GPL (GNU (Lesser) General Public License);- which is computer platform independent (i.e., runs on most hardware, or is portable to any appropriate hardware with modest effort);- which is robot independent (i.e., has software modules that can be adapted (with modest effort) for all known robot hardware, manipulators as well as mobile robots);- which is modular and distributable (e.g., using the CORBA standard for distributed components);- which obeys international standards;- which integrates with, and reuses the open source software code of, relevant complementary projects (e.g., for 3D visualisation, numerical methods, networking, etc.).Note that the goal of the OROCOS project is just to produce a functional basis, and not a full-blown robot software system!Work description:The project contains three major components:Core component and interoperability identification;design and implementation of components;and documentation.The specific modules that will make up the presente
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Gene mining of metagenomes for novel enzymes and therapeutics' in the context of a Fifth Framework call.

assistant: **Objectives**

Microbial diversity is a key element in the search to new, valuable compounds such as enzymes with novel properties for industrial applications or which may lead to new or modified antimicrobials. Only a limited number of microorganisms from the environment can be cultured. Therefore, this project will exploit the vast genetic potential of the unexploited Met genome in a culture-independent process using functional genomic, PCR-based screens and in silicon gene mining. The deification of novel genes coding for plant cell wall degrading enzymes and antimicrobials will be emphasized. Their expression potential in industrially important hosts to give economically relevant yields will be investigated. Altogether, the project will combine the enormous potential of biodiversity with cutting edge screening technology, molecular biology and bio informatics to develop products with high biotechnological or pharmaceutical value.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Metal-containing Radical Enzymes' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The pharmaceutical, chemical and polymer industries are cornerstones of Europe’s economy. A key element for theirtransition to more sustainable processes and to innovative new compounds is biocatalysis.Of particular interest are metallo-enzymes, i.e. proteins that host a metal cofactor. They catalyze a multitude of redox andradical reactions. To access reactions that are unknown in nature, artificial metallo-enzymes can be created. They combinethe new-to-nature catalytic activity of metal complexes with the selectivity-inducing environment of the active protein site.To develop novel biocatalysts, a highly interdisciplinary skill set is needed. MetRaZymes will create a PhD school acrossleading European universities that will train the next generation of scientists capable of tackling the design, development andimplementation of novel enzymatic reactions in a holistic approach. It brings together computational bioscientists,bioinorganic and polymer chemists, and bioprocess engineers. Using artificial and repurposed metalloenzymes as the focalpoint, the ESRs will develop novel biocatalysts for radical reactions of high synthetic value, such as the late stagemodification of pharmaceutical intermediates or the synthesis of polymers from renewable monomers. To train the ESRs inthe needs of industrial biotechnology, the consortium includes eight of Europe´s leading pharmaceutical, chemical andenzymology companies. The ESRs will benefit from a vast transferable skills training program delivered by five trainingpartners. Highlights include a Nature Masterclass and Wikipedia workshop. Communication partners such as Wikimedia andthe Industrial Biotechnology Innovation Centre will act as muliplicators for the communication of results. Moreover, the ESRswill work with artist that us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Smartness, Health Assessment and Performance Evaluation' to be submitted under Horizon 2020.

assistant: **Abstract**

I aim to address association of health, wellbeing, smartness and indoor environmental quality (IEQ) with nearly zero energy buildings (nZEBs) in Université catholique de Louvain (UCLouvain, Belgium) under the supervision of Professor Sergio Altomonte. We are living in a decade in which problems such as climate change, global warming, lack of resources, detrimental impact on human health and solutions such as sustainable development, resilient environments, mitigation of carbon emissions, excellence in energy efficiency have never been much more significant before. The Directive 2018/844/ EU amending the Energy Performance of Buildings Directive (EPBD) Directive 2010/31/EU) indicates the requirements for nZEBs. Post-occupancy evaluation (POE) and building performance evaluation (BPE) are significant processes to assess user satisfaction, identify problems in buildings and develop solutions. The main aim of SHAPE project is to propose, deploy, and validate a new BPE tool for healthy and smart nZEBs, tracking holistically and measuring rigorously user comfort, health and well-being, alongside buildings’ energy efficiency and smartness. As the first step of the research methodology, a framework of performance indicators for healthy and smart nZEBs will be created. Secondly, a BPE tool will be developed for assessing health, wellbeing, productivity, IEQ and smartness for new and renovated nZEBs in use. In the third step, the developed BPE tool will be validated in selected existing smart nZEBs. Furthermore, the BPE tool will be finalised in the fourth step and disseminated in the fifth step. In conclusion, the BPE tool will identify problematic areas in nZEBs and recommend improvements for a better building performance with a higher quality for occupants considering human f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'A system approach to optimising diagnosis of smear-negative tuberculosis in high and low prevalence countries of south-america'.

assistant: **Objectives**

Smear-negative pulmonary tuberculosis (SNPTB) is a problem both for clinicians, and for tuberculosis programme managers. This research project approaches SNPTB from three different perspectives:(1) the laboratory perspective, by testing the feasibility of more valid and efficient methods for quality assurance of smear-microscopy,(2) the clinical perspective, by testing the clinical audit cycle as a method to improve the quality management of smear-negative tuberculosis suspects and the validity of diagnostic work up and(3) the health services organisation perspective in relation to (de)centralisation of different elements of the diagnosis of smear-negative tuberculosis. This study will contrast high and low incidence, centralised and decentralised, urban and rural settings. HIV-related aspects will be examined. Special emphasis is given to the operationalisation and dissemination of study findings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Through Understanding of Socioeconomic Metabolism towards Sustainability' (THUNDER).

assistant: **Concept**

The aim of this research project is to identify the link between environmental problems and their drivers. While production activities are responsible for most of the environmental impacts, they are ultimately driven by the final consumption of goods and services. This project will focus on further development of footprint indicators (indicators which assign environmental burden from the whole production chain to final consumers) by their integration into environmentally extended multiregional input-output analysis. Some indicators, such as human appropriation of net primary production, will be calculated from the consumer responsibility perspective for the first time and others, such as nitrogen footprint, will be for the first time integrated into a multi-regional input-output framework. A consolidated set of footprint indicators will be established for the most important environmental problems identified by other researchers. It will provide policy makers with evidence regarding environmental burdens abroad induced by domestic consumption. The set of footprint indicators will help them to measure progress in environmental areas and set up policy goals. A set of footprint indicators is necessary in order to avoid shifting environmental burden from one region to another and across environmental areas. This interdisciplinary project bridges economics and natural sciences and utilizes knowledge from both.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transposition mechanism and the 3' region of the i-factor, a line-like transposable element - ii' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content The main objective of this research project is the functional analysis of the RNase H and zinc-finger motifs located in the 3' region of I factor-like elements. These domains, as well as the termination mode, are characteristic of this subgroup of elements and are not included in the present model of transposition of LINE-like elements. The activity of these domains has not even been tested. As a second objective, ) would like to test the hypothesis that I factor-like elements are retrotranscribed in the cytoplasm.Once established a suitable in vitro transposition system for the I factor element (contract number ERBFMBICT972688), the project will involve the analysis of how site-directed mutation in specific sites of the RNase H and zinc-finger motifs of this element affect its transposition capability. Training content (objective, benefit and expected impact) This whole research project will be acquainted me with completely new techniques on molecular biology, like cell culture, making and handling of gene constructs, site-directed mutagenesis and perhaps protein expression and its analysis. The knowledge or this technology can be useful not only for the development of this project but to analyse any other gene. Working on two different research groups, I will benefit from the training ability of both laboratories as well as an specialised supervision on each part of the investigation. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reinterpreting how forests support people's dietary quality in low-income countries' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Two billion people across the planet suffer from nutrient deficiencies. Dietary diversification is key to solving this problem, yet food security policy, especially in low-income countries, still focuses on increasing agricultural production and access to sufficient calories as the main solution. But calories are not all equal. Indeed, this approach has created a blind spot with respect to the role of forests, which are often overlooked but may be important for dietary diversification for the rural poor by providing wild foods, high-value products which can be sold and thereby enable food purchases, and fodder for livestock which then provide meat, milk and eggs as well as manure to improve agricultural production. This project will identify how forest loss and fragmentation affect people’s dietary quality. I will apply a cutting-edge multi-scale, multi-country, and data-rich approach. First, I will take a broad-scale perspective to explore where forest loss, forest fragmentation, and dietary changes are taking place and identify hotspots of forest change and deteriorating diets. To do so, I will spatially link publicly available household data on food consumption, with metrics on the proportion and spatial arrangement of forest from longitudinal datasets. Second, I will unravel the mechanisms linking forests and diets to develop a comprehensive framework on forest-diet linkages. Third, I will zoom in on selected sites in two countries and use in-depth fieldwork to elucidate causal relations between forests and dietary outcomes locally. The project will break new ground by providing the first generalizable empirical evidence of how and why forests influence dietary quality in low-income countries, thereby laying the ground for a shift in how we think about pathways to f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Towards a New Theory of Optimal Dynamic Graph Algorithms'.

assistant: **Innovation**

Dynamic graph algorithms are of increasing critical importance. They are crucial for coping with dynamic networks, which model the ever-changing physical world, and have been instrumental in achieving numerous major breakthroughs in static graph algorithms.The holy grail in the field of dynamic graph algorithms has been to design algorithms with poly-logarithmic (in the input size) update time. However, recent exciting developments, in which the PI has played a central role, aim to push the update time toward an absolute constantindependent of the input size  which is qualitatively very different than a poly-log bound.This goal is of fundamental importance not just from a theoretical perspective, but also from a practical viewpoint, due to the rapidly growing size of modern networks.An algorithm is intrinsically optimal if its update time matches the ratio of the problems static time complexity to the input size. The main question underlying this research is:Which graph problems admit intrinsically optimal update time?Only few intrinsically optimal graph algorithms are known.  The unique goal of this project is to establish a systematic study of intrinsically optimal algorithms. We will also study provably optimal algorithms, aiming to advance our understanding of the thin line that separates these two distinct optimality notions. To achieve this goal, we must go far beyond the current state-of-the-art, and in particular, confront some of the most central problems in the field. Meeting the projects main goal, even partially, will be groundbreaking. Results of this project will facilitate the use of dynamic algorithms in real-world application domains, and will also be illuminating to other fields, such as distributed computing and fine-grained complexity. Consequently,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Research training in mathematical medicine and Biology at the University of Nottingham' (MMBNOTT) targeting Sixth Framework.

assistant: **Abstract**

The Centre for Mathematical Medicine (CMM) at the University of Nottingham comprises a large group of applied mathematicians, applied probabilists and statisticians who undertake multidisciplinary research in a broad range of topics of relevance to the life sciences.Working closely with collaborators in biomedical disciplines based elsewhere at the University of Nottingham, this team is one of the largest groups of its kind in Europe. It undertakes internationally- leading research using a wide range of mathematical, numerical and statistical techniques.Funding is sought for 10 Fellows to come to Nottingham, each for a 3-year period, in order to undertake directed training in the application of mathematical and statistical methods to the life sciences.The training of each Fellow will include a substantial individual research project on a topic relevant to an area of molecular biology, cell biology, physiology, neuroscience, immunology or tissue engineering.Each project will be conducted under the supervision of two CMM members (ensuring that each Fellow develops skills in both deterministic and stochastic modelling approaches) and an experimentalist (ensuring that the project is highly relevant to the underlying biomedical application).Fellows will receive comprehensive training in relevant research methodologies and in generic research and transferable skills, through taught modules, taught courses, workshops, seminars and individual supervision.Fellows will work in a unique and stimulating research environment, which offers training that is both strongly multidisciplinary (through exploitation of a wide range of mathematical and statistical methods) and interdisciplinary (through close contact with experimental applications).The Programme will equip Fellows with the s