RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Psychology of Administrative Burden' in the context of a Horizon 2020 call.

assistant: **Objectives**

The burdens of dealing with administrative rules and red tape in government are a fact of life around the world, ranging from small hassles to heavy burdens in the form of stigmatizing processes of proving eligibility and facing potential sanctions. In light of the immense importance of such burdens for millions of people and for the effectiveness of benefit programs, we know surprisingly little about the conditions that give rise to experiences of burden. POAB combines and extends extant theory and uses a unique combination of experimental methods and data to explain how, why, and for whom administrative rules are experienced as burdensome.POAB studies comprehensive rules regarding unemployment and social benefits and will provide novel register, physiological, and survey measures of welfare benefit recipients’ experiences of burden. I develop and test three theories to explain differences in experiences of burden: 1) How resource scarcity causes cognitive load and hence reduces the ability to cope with rules; 2) How self-efficacy increases the ability to cope with rules; and 3) How perceptions of being undeserving cause stigma and stress.POAB analyses the causal impact of rules on burden. To this end, I use a unique combination of complementary experimental methods in political science: 1) Cross-national lab experiments with physiological measurement and manipulations of rules, scarcity, efficacy and deservingness perceptions; 2) Cross-national survey experiments to assess different aspects of rules in different contexts; 3) Quasi- and field experiments to assess the impact of rules on register measures of burdens in a real-world context.POAB offers a fundamentally new interdisciplinary approach by bridging the gap between research on administrative burdens and psycho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multidisciplinary evaluation of the diagenetic and weathering signature on the paleomagnetic record from neogene to recent sediments', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The proposed research aims at achieving an interdisciplinary in-depth analysis of the impact of the diagenetic and weathering processes on the paleomagnetic record of some marine sediments. For this purpose a variety of both rock magnetic, petrographic observations and geochemical techniques will be employed. Further, a suite of multivariate statistical techniques will be applied to interpret the data and thus the development of new interpretational approaches is envisaged. This will contribute to a more rigorous knowledge of the acquisition mechanisms of the paleomagnetic signal in sedimentary rocks, which is of urgent need before adequate and meaningful interpretations can be gathered from the available high-resolution paleomagnetic records. In the underlying proposal both land-based Neogene marine sequences as well as available (piston) cores will be targeted permitting thus to evaluate the (potentially) varying influence of diagenesis and weathering. In conjunction, the validity of currently applied criteria for paleointensity determinations will be assessed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Deciphering deep architectures underlying structured perception in auditory networks' in the context of a Horizon 2020 call.

assistant: **Objectives**

The principles of sensory perception are still a large experimental and theoretical puzzle. A strong difficulty is that perception emerges from networks of recurrently connected brain areas whose activity and function are poorly approximated by current generic mathematical models. These models also fail to explain many of the fundamental structures effortlessly identified by the brain (shapes, objects, auditory or tactile categories). I here propose to establish a new approach combining high-throughput population recoding methods with a tailored theoretical framework to derive computational principles operating throughout sensory systems and leading to biologically structured perception. This approach follows on the recent mathematical proposal, suggested by Deep Machine Learning methods, that complex perceptual objects emerge through series of simple nonlinear operations combining increasingly complex sensory features along the sensory pathways. Starting with the mouse auditory system as a model pathway, we will recursively extract, with model-free methods, the main nonlinear sensory features encoded in genetically tagged output and local neurons at different processing stages, using optical and electrophysiological high density recording techniques in awake animals. The role of these features in perception will be identified with behavioural assays. Specific intra- and interareal feedback connections, typically not included in Deep Leaning models, will be opto- and chemogenetically perturbed to assess their contribution to precise nonlinearities of the system and their role in the emergence of complex perceptual structures. Based on these structural, functional and perturbation data, a new generation of well-constrained and predictive sensory processing models will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mechanisms linking stress and ageing in two avian species exhibiting contrasted natural resistance to stress (NAtural REsistance to Stress-Induced Cellular Ageing)' (NARESICA).

assistant: **Innovation**

Previous research has identified stress exposure as a key factor influencing health state and ageing rate. The overall aim of the proposed project is to investigate the precise mechanisms linking stress exposure to accelerated cellular ageing (using telomere length as a biomarker of ageing), and to identify potential mechanisms allowing some species to better prevent stress-induced ageing than others. To this aim I will use two avian species (Japanese quail and king penguin) to investigate (1) if chronic stress affects telomere shortening differently between species exhibiting contrasted stress resistance, (2) if glucocorticoid ‘stress’ hormones are directly responsible of the stress-induced alterations in telomere dynamics, (3) by which mechanisms (i.e. alterations of mitochondrial function, oxidative stress and DNA damage, impaired mTOR cellular signalling or telomere maintenance) stress exposure is accelerating telomere shortening, and if king penguin have specific mechanisms preventing/limiting stress-induced telomere shortening, and (4) if chronic stress / glucocorticoid hormones modify the acute oxidative stress responses of individuals. To this end, I will employ experimental approaches manipulating stress exposure and glucocorticoid hormones in captive Japanese quail and wild king penguins, and measure the resulting impact on telomere shortening and its potential cellular drivers (mitochondrial function, oxidative stress, mTOR cellular signalling). This project will enable a two-way transfer of skills and competences between the applicant and the host, by providing training to the applicant regarding mitochondrial biology, cellular signalling and gene expression, and by providing the host with the opportunity to integrate an ageing component through the use of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploring Strongly Correlated Quantum Matter  with Cold Excited Atoms' under Seventh Framework.

assistant: **Concept**

The understanding of quantum matter in and out of equilibrium is among the biggest challenges of modern physics. Despite decades of research fundamental questions, such as the preciseworkings behind rather ubiquitous materials such as high temperature superconductors are still unresolved. At the same time there is a new generation of experiments approaching which realises and probes quantum matter with novel and exotic interactions at an unprecedented level of precision. This has already highlighted new avenues of research but also demands for radically new theoretical approaches which lie outside the scope of just a single traditional physical discipline. Novel and in particular multidisciplinary lines of thinking are required to tackle this immense challenge. Such new research will not solely be delivering invaluable insights into currently unresolved problems but rather form a new basis for the understanding of quantum matter from a multidisciplinary perspective. This will open up new horizons for fundamental research and at the same time will pave the way for future technologies and materials which rely on non-equilibrium phenomena or quantum matter. This research proposal takes on this challenge by setting up a broad theoretical research programme which is multipronged and multidisciplinary and which directly connects to the most recent research efforts in ultra cold atomic physics. Here currently a step change is taking place where new experiments explore strongly correlated quantum physics within gases of excited atoms – so-called Rydberg atoms.  Exploiting this unique moment we will develop a framework for the description of the equilibrium and non-equilibrium properties of these complex and very versatile quantum systems. This system-specific research approach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mapping metabolic regulators at a genome-scale to switch bacteria from growth to overproduction of chemicals' (MapMe), addressing dissemination and exploitation.

assistant: **Impact**

Metabolic engineering creates improved microbes for industrial biotechnology. Rational design of industrial microbes centres on modifications of genes with known roles in the production pathway of interest. However, genes that are unrelated to the production pathway are also known to substantially impact productivity. To date there are no methods that allow the prediction of such distal genes on a rational basis. Effects of distal genes are indirect, and mediated through regulatory interactions between metabolites and proteins, most of which are currently unknown even in the well-studied microbe Escherichia coli. The lack of knowledge of metabolite-protein interactions thus effectively prohibits systematic exploration of distal regulatory relationships, with the consequence that models used to predict metabolic engineering targets are severely limited and rarely applied in industrial biotechnology. Previously, we used small-scale metabolic models and metabolomics to infer metabolite-protein interactions in specific pathways. In this project we propose a novel genome-wide endeavor to map metabolite-protein interactions across the entire metabolic network. For this purpose, we will use the recently developed CRISPR interference system to quantitatively perturb >900 single metabolic genes in E. coli. Combining the metabolomics data of these >900 gene perturbations with a genome-scale metabolic model will enable us to infer functionally relevant metabolite-protein interactions. Finally, we will apply this knowledge to the model-guided metabolic engineering of superior E. coli strains. Specifically, we want E. coli to cease growth upon induction and focus all its metabolic resources towards synthesis of succinic acid. This controlled uncoupling of growth from overproduction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Complete Characterization of Photochemical Reactions by Time- and Energy-Resolved Electron Scattering' to be submitted under Horizon Europe.

assistant: **Abstract**

Many processes in nature and industry are intricately linked to the structure-function relationship of molecules, which optical stimuli can profoundly alter. Chemists and physicists have long sought to unravel the ultrafast structural changes of photochemical reactions. Using two short pulses with precisely synchronized time delays, a series of snapshots of the evolving electronic and molecular structures at various reaction times can be collected, analogous to assembling frames in a video. Measuring coupled electronic-nuclear dynamics remains a formidable challenge due to the small time, energy and spatial scales involved. State-of-the-art ultrafast electron diffraction (UED) techniques excel in molecular structure retrieval, but the critical signatures stemming from simultaneous transformations in electronic structure remain elusive, as several molecular reaction channels overlap and cannot be separated with current imaging technologies.My goal is to pioneer a novel time- and energy-resolved electron scattering (TERES) method for real-time monitoring of coupled electronic-nuclear dynamics in photochemical reactions by energy-resolving UED. TERES will experimentally separate and identify electron scattering signals arising from different electronic structures of excited molecules (e.g., in different excited states) while preserving molecular structure information, comprehensively mapping the potential energy surfaces involved at different reaction times  capabilities significantly exceeding current UED technology. Successful realization of TERES promises to usher in a new era in photochemistry, unveiling hidden aspects of chemical reactivity.


**Keywords:** Ultrafast electron diffraction, femtochemistry, ultrafast molecular dynamics, electron energy loss spectroscopy,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'How do people perceive the 15-minute neighbourhoods globally? Investigating public perception across developed and developing worlds' (15MINCITY) under Horizon Europe.

assistant: **Objectives**

Over recent years, the novel concept of the 15-minute city is gaining traction across Europe and beyond due to the numerous benefits that it can yield for local communities. Although it builds upon previous urban planning movements and ideas, repackaging them has contributed to extra attention when re-inventing the desired neighbourhood structure at this time of global resource constraints, climate change, vulnerable settlements, pandemics, and social exclusion. The concept promotes a proximity-based approach in neighbourhoods planning and design by which accessing daily needs for locals is guaranteed in a 15-minute walk/bicycle ride of their home. While the fundamentals of the concepts are promising, a prescriptive nature, like its previous counterparts, does not allow for understanding how popular it is for people and replicable across various contexts. In fact, much less is known about the applicability of this new approach with regard to diverse contexts and clients. The present research project will thus shed light on exploring the way people perceive this novel planning and design approach in various urban contexts worldwide. This research follows a case-study design, with an in-depth analysis of public perception, that is based on a combination of qualitative and quantitative methods. The empirical study on context-sensitivity is conducted using predefined developed and developing cities represented by Brussels and Tehran, respectively. These findings contribute in several ways to our understanding of the 15-minute city concept and provide a basis for future applications, having multiple scientific, social, and environmental impacts on global communities in long term.


**Keywords:** The 15-minute city,  public perception,  accessibility,  urban mobility, proximi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Optimisation of the service life of production tools in hot forging, die casting and glass forming by minimising the risks related to thermal fatigue' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The main objective of this project is to develop a computer aided decision support system for improving the service life of production tools which are exposed to severe temperature changes and are therefore sensitive to thermal fatigue failure. Hot forging, die casting and glass forming operations are typical process where these phenomena occur and strongly affect the economy of production and quality of products. The research and development activities will include fundamental investigations by micromechanical modelling and laboratory experiments as well as development of a computer aided decision support system which will be assessed in industrial practice. Micromechanical modelling will be performed by a discrete element approach in order to improve fundamental understanding of the mechanics influencing thermal fatigue failure. Theoretical investigations will be supported by experimental tests which are often very expensive since thousands of thermomechanical loading cycles need to be performed for different combinations of materials and contact conditions. Therefore, an economically efficient laboratory test which represents a wide range of industrial processing conditions will be developed. Te expertise gained in the combined micromechanical and experimental approach will enable formulation of a sound constitutive model which will be implemented into a finite element based decision support system for predicting risks related to thermal fatigue. The decision support system will be applied to optimise tool service life in hot forging, die casting and glass forming operations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Developing novel models of Amyotrophic Lateral Sclerosis using motor neuron cultures and zebrafish'.

assistant: **Concept**

In 2008, I led a team that identified mutations in the TAR DNA binding protein (TARDBP) gene that encodes TDP-43 in ALS patients, which is enriched in inclusion bodies present in motor neurons from ALS patients. Also, mutations in the fused in sarcoma (FUS) gene were identified in ALS patients, with FUS involved in similar molecular mechanisms as TDP-43. This project aims to elucidate mechanisms involved in motor neuron degeneration caused by TDP-43 and FUS and to develop in vivo models to discover potential ALS therapies. Mutant TDP-43 causes degeneration in motor neurons from primary spinal cord cultures. Injection of mutant FUS in these cells will be conducted to determine if motor neurons are selective vulnerable to mutant TDP-43 or FUS. We also aim to characterize protein partners of mutant FUS/TDP-43 using immunoprecipitation and proteomic studies.Zebrafish is an excellent vertebrate model well suited for multigenic analysis and chemical screening in development and disease. Preliminary results suggest that knock-down of tardbp or fus as well as overexpression of mutant FUS and TDP-43 cause deficits in locomotory behavior and delayed axonal outgrowth in motor neurons from zebrafish. I am currently undertaking a multigenic analysis of TARDBP and FUS and previously ALS-related genes (SOD1, ALS2, VAPB) to discover whether common pathogenic pathways lead to motor neuron disorder. Finally, transgenic lines expressing mutant TDP-43 or FUS and fish lines with deletion of tardbp or fus genes are being generated and screened for motor neuron phenotypes. These lines will represent optimal ALS models to determine in vivo molecular mechanisms of pathogenesis. Further, our group is developing an automated platform in order to screen a large library of pharmaceutical compounds.