RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An Interdisciplinary Analysis of GenAI’s Systemic Risk to Cultural Pluralism in the Music Sector' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

musAIc aims at exploring whether the legal category of systemic risk recently provided by the AI Act can include the systematic impacts posed by certain generative AI systems (genAI) on the fundamental rights of cultural pluralism.The use of genAI is growing rapidly, particularly in the music domain, which accounts for 8% of its global market. While their indisputable economic and societal benefits are well recognized in existing literature, concerns about their potential negative impacts on cultural pluralism are raising. Nonetheless, so far scholars have not yet fully acknowledged these impacts as systemic risks according to EU digital law (including the Digital Services Act), nor as potentially leading to cultural impoverishment.Focusing on the music sector as a paradigmatic case, musAIc aims to address this gap by building a new framework to facilitate the development of the methodology and criteria required by Art. 51 and ff. of the AI Act and the drafting of codes of practice (Art. 56). To build it, I will analyze and test in practical environments what is a creative process within an algorithm-dominated context, and I will explore cultural impoverishment as a possible consequence of the architecture of these systems and their usage context. This will culminate in developing guidelines to aid stakeholders to assess this risk and EU policymakers to address it.To reach this goal, musAIc uses a strong interdisciplinary approach, bridging law, sociology and computer science and considering the needs of the general public as well as professional and amateur musicians.To ensure the successful completion of the project, I will conduct my research at both EU and non-EU institutions (Switzerland, US) -which is invaluable for the global nature of the issues at its core and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'International Cooperation 0n Semiconductors' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The objective of this project is to support the EC in defining topics and measures to strengthen the position of Europe in the global value chain of semiconductor and semiconductor-based photonics, by focussed cooperation initiatives with other leading semiconductor regions.The starting point will be the identification of European and non-EU industrial strengths and gaps in the field of semiconductors with the support of industrial organization, while emerging technologies will be explored through the participation of leading research centres.The project will profit of already existing international cooperation initiatives among regions, like ITRS2 and IRDS, to define possible cooperation areas and modes. ICOS will also benefit from a project leader who has matured extensive experience in the coordination of 6 EU projects in the field of semiconductors.As a result, the project will provide advice to the EC on joint actions to be implemented with leading semiconductor countries to reinforce the European position, supported by an in depth analysis of risks vs. expected benefits. The actions may include exchange of research results, joint research activities, researchers’ exchange programs and joint definition of standards.A proper dissemination of results will take place through joint events and participation to main conferences of the sector, both European and international.


**Keywords:** International cooperation in semiconductors, Semiconductor economic analysis, Advanced computation, Advanced functionalitiy in integrated circuits, Emerging semiconductor technologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Primary mouse hepatocytes as a model system to study polarized endocytic trafficking'.

assistant: **Concept**

Hepatocytes as polarized cells consist of two distinct membranes, the apical (towards the bile) and the basolateral (towards the blood and each other). Discrete endosomal networks and machineries are responsible for their proper maintenance and function. Therefore, internalized cargo is delivered specifically via different populations of endosomes to the apical and basolateral membranes ensuring their specificity in trafficking and signaling. Isolated mouse hepatocytes maintain polarity and in vivo functionality when cultured using a 3D collagen sandwich system and provide therefore a good model system to study polarized trafficking. By adapting functional transport assays we can quantitatively measure the flow through the endosomal system using immunofluorescence microscopy. The aim of our project is to develop a mathematical model that can describe and predict the behavior of the endocytic pathway in hepatocytes with respect to cargo transport as well as signaling. It is clear in fact from resent studies that a complete understanding of the signaling machinery will not be achieved without taken into account the endocytic trafficking of signaling molecules. To pursue this goal, we set out to characterize in a quantitative fashion the endosomal distribution in the apical versus basolateral area by using confocal imaging analysis. The acquired data are fit into modeling software, to model mathematically the endosomal system. These results are compared with data we obtained in non-polarized HeLa cells. This system has been used to identify regulators of endocytosis in a functional genomics screen. The genes identified therein will be tested in isolated primary mouse hepatocytes. This will help us to understand the function of the endosomal system in hepatocytes and how it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Deciphering host-microbiome  interactions in anti-cancer immunity' (MICROBIOGUARD) under Horizon Europe.

assistant: **Objectives**

Despite unprecedented clinical success, T cell-based immunotherapies present significant heterogeneity in response rates, often attributed to dampened activation and limited tumour infiltration of CD8+ T cells. Studies in mice and humans have shown that gut commensals can modulate anti-cancer immune responses dictating the efficacy of immunotherapy, but have failed to identify species that are consistently associated with improved patient prognosis. I recently made a breakthrough in our efforts to understand the host determinants that define microbiome-dependent cancer immunity. I discovered that a single micronutrient, vitamin D (vitD), enhances the ability of the gut microbiome to induce potent T cell-mediated immunity to cancer, dictating immunotherapy success in pre-clinical models. Unlike any other study, I found that vitD modulates the function of the microbiome without significantly affecting its composition, diverging from a species-centric view of the microbiome to focusing on key host-microbiome interactions regulated by nutrient availability.MICROBIOGUARD attempts to systematically dissect the multidirectional gut-immune-cancer axis. We first address a key question in the field: what defines a good microbiome that promotes immunity to cancer? Aim 1 of this proposal will dissect the mechanisms by which vitD transforms the function of the gut microbiome with a focus on identification of microbial-derived bioactive molecules. We will then assess how these altered microbial functions interact with host cells bidirectionally to shape anti-cancer immunity (Aims 1/2). We will broaden our findings and determine how vitD-microbiome-immune interactions impact cancer development. Finally, we will investigate if vitD enables human microbiome to augment immunotherapy resp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of Short Distance WELding Concepts for AIRframes (WEL-AIR project)' (WEL-AIR), addressing dissemination and exploitation.

assistant: **Impact**

The age of sustainable growth in which the world aeronautics is entering will require to the Research and Technology development to contribute to the strengthening of the competitiveness of the aeronautic manufacturing industry with more economical, performant and better quality products. Weight and cost efficiency will be obtained on the Integral Structure" or "Rivet-Free"Al-alloy airframes through the use of advanced welding technologies such as laser beam (LBW) and friction stir welding (FSW) and the introduction of new aluminium alloys with improved performances : welded integral structures are claimed to offer a cost saving of up to 60% over built-up structures. Large distance LBW skin-stringer joints for manufacturing of panels of the current fuselage of A318 are used and similar applications are also planned for other next generation aircrafts. Now, there is a need to extend this current level of technological achievement to "more critical and difficult-to-join" sections of the metallic airframes through replacement of conventional riveted sub-sections with short distance welded integral structure which exhibits lightweight and damage tolerant features. The main scientific and technological objectives of the project are : * To optimise and validate the most suitable short distance LBW process parameters for various Al-alloy combinations for joining of stiffener/cleat-skin connections (containing run-outs) of the airframes by understanding and control the basic mechanisms of the hot tearing, crack initiation and crack growth.* To develop short distance friction stir welding process for some FSW suitable joints and non laser weldable alloys and hence gaining new knowledge for both joining processes for such new applications.* To develop repair schemes of short dist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Early Earth Dynamics: Pt-Re-Os isotopic constraints on Hadean-Early Archean mantle evolution' (2007-2013).

assistant: **Innovation**

This project aims to directly constrain the melting history and composition of the mantle of the Earthfor the first 750 Ma of its history. So far, our limited knowledge hinges on isolated detrital zircons fromArchean crustal rocks. They indicate crustal extraction as early as 4.4 Ga with peaks at 4.0 and 4.3 Ga butreveal conflicting models for the composition of the Hadean mantle. Both the timing and extent of theseearly crust formation events and the composition of the Hadean mantle have crucial implications for ourunderstanding of the Early Earth’s chemical evolution and dynamics as well as crustal growth and thermalcooling models. Sulfides (BMS) and platinum group minerals (PGM) may hold the key to these fundamentalissues, as they are robust time capsules able to preserve the melting record of their mantle source overseveral billion years.I propose to perform state-of-the-art in-situ Pt-Re-Os isotopic measurements on an extensivecollection of micrometric BMS and PGM from Archean cratonic peridotites and chromite deposits, andpaleoplacers in Archean sedimentary basins. For the first time, < 20 μm minerals will be investigated for Pt-Re-Os. The challenging but high-resolution micro-drilling technique will be developed for in-situ samplingof the PGM and BMS with subsequent high-precision 187Os-186Os isotopic measurements by NTIMS. Thishighly innovative project will be the first to constrain Hadean Earth history from the perspective of theEarth’s mantle. By opening a new window towards high-precision geochemical exploration for micrometricminerals, this project will have long-term implications for the understanding of the micro to nano-scaleheterogeneity of isotopic signatures in the Earth’s mantle and in extra-terrestrial materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Jet exhaust aerodynamics and noise (JEAN)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The JEAN proposal will address the prediction of noise by jet flows including the effects of mixing enhancement and co-axial configurations CFD techniques will be applied and validated to predict the turbulence characteristics of jets. These will be coupled to noise source generation and propagation models to estimate the near and far field noise. The results will be critically evaluated against data obtained from a series of carefully designed experiments. The validated noise prediction procedures will be applied to mixing enhancement and to co-axial jets and the results compared with existing high quality data for these configurations. The work will recommend the use of a particular suite of techniques which will have been validated for specific applications. These will then provide the basis for the development valuation tools for new concepts in low noise design of jet engines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Welcome to the age of frictionless mobility.', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

MagRail will bring frictionless mobility (levitating trains) to conventional tracks. Our system upgrades a conventional railway line with MagRail infrastructure components (linear motor and levitation beams), supplemented by signaling and traffic control system, and vehicle components (e.g. bogie).As a result, MagRail allows for interoperability of conventional and magnetic trains on the same track, which makes the system unique. Retrofitting conventional railway lines’ (speeds up to 160 kph) or high-speed railway lines’ (330 kph) infrastructure into MagRail will allow to substantially increase the speeds to up to 330 and 550 kph respectively, which will bring massive savings in time and money.MagRail will radically increase the capacity and flexibility of railway lines, bringing more goods and passengers to railways, supporting a real modal shift from road, air, and sea to rail, making zero-emissions goals and sustainability targets more achievable.


**Keywords:** Design innovation,Multimodality
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Functional and structural studies of the U12-dependent splicing in human cells' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Introns are non-coding segment of eukaryotic genes, which are removed from precursors of messenger RNAs (pre-mRNAs) by a large and dynamic RNA-protein complex known as the spliceosome. In human cells, most of the introns are processed by the canonical U2-dependent, major spliceosome. Around 0.5% of human introns utilise an alternative splicing pathway, catalysed by the minor spliceosome, which depends on the U12 small nuclear RNA (snRNA). While U12-dependent introns are rare, often they are located in genes with critical cellular functions and mutations in the minor spliceosome components lead to several genetic disorders. MinorSplice project aims to perform a comprehensive structural and functional characterization of the U12-dependent splicing pathway. The functional studies will be focused on the proteomic characterization of the minor spliceosome assembly intermediates and the involvement of the conserved spliceosomal RNA helicases in the U12-dependent splicing pathway. By combining cell-based assays, proteomics and next generation sequencing methods we will create a detailed picture of the minor spliceosome composition and associated regulatory mechanisms. The core of the projects aims to determine a series of minor spliceosome’s structures using single particle electron cryo microscopy (cryo-EM). We expect that high-resolution structural information will answer some of the fundamental mechanistic questions about the minor spliceosome assembly, U12-dependent intron recognition and will shed a light on structural similarities and differences between the major and minor splicing pathways. The last part of the project will aim to visualise spliceosomes in the native cellular environment using electron cryo tomography (cryo-ET). By doing so, we anticipate to obtain fun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Electrochemical and optical properties of ordered polymer films consisting of end grafted rod like polymers on flat solid surfaces' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Orientation of polymers on a substrate can lead to interesting applications in the field of non-linear optics and conducting or magnetic polymer films. By end-grafting a polymer with a stable secondary structure to a solid surface, a random orientation of the polymer chains is prevented and relaxation can not occur. These polymer brushes" have received considerable theoretical attention over the years. Polypeptides, which are able to form stable Alpha-helices, are excellent polymers for this purpose. I propose to end-graft (co)polyglutamates to flat surfaces in order to obtain the ordered thin polymer films, in which the physical properties arise from the oriented main chains or from functional side chains like polypyrrole. I would like to investigate the ordering and orientation of grafted layers as a function of graft density. This can be done by several techniques available at the MPI/Polymerforschung, the proposed host institution. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Opportunities for re-engineering business processes through advanced it' to be submitted under Fourth Framework.

assistant: **Abstract**

ORBIT is a two year programme of interactive training and dissemination events in the EU and Eastern Europe. It is designed to increase the awareness of senior executives in the process industries as to the major manufacturing advantage to be achieved by strategic investment in advanced IT solutions. The programme of ten conferences, conducted under international business school conditions and including a specially written case study, will enable managers to identify their own business drivers and the necessary steps to developing the most effective business processes underpinned by flexible, open architecture IT solutions. Well defined IT investment plans, produced by user companies participating in the ORBIT programme will provide essential guidance to IT suppliers who have already expressed strong support for this user-driven approach. Endorsed under the PRIMA cluster of projects with shared technology brokerage, ORBIT should lead to a greatly increased uptake of IT solutions emerging from ESPRIT projects.