RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dynamics of transporters dependent on ubiquitin in plants : mechanisms, roles in plant nutrition and beyond' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Cells use a battery of cell-surface proteins to monitor their environment, communicate and take up nutrients. The mechanisms driving the temporal and spatial distribution of plasma membrane are therefore of critical importance for growth and development. Endocytosis dependent on ubiquitin (Ub) has been mostly involved in the retrieval of cell-surface proteins and their targeting to the lysosome/vacuole for degradation in mammals and yeast.Higher plants evolved from an ancient branch of the eukaryotic tree and are more distant from animals and yeast than the latter two are from each other. In parallel, a huge number of gene families in plants have undergone independent expansion and a significant percentage of plant genes have no orthologs in yeast and animals. As such, a great number of endocytic processes in plants are mediated by factors known in animals but used i) in different ways, ii) mediated by plant-specific factors, or iii) using factors belonging to dramatically expanded families for which no functional information is available.My work recently demonstrated the existence of Ub-mediated endocytosis in plants, using the root iron transporter IRT1 as a model. IRT1 represents a unique opportunity to address ubiquitin-dependent trafficking and to study the functional link between a fundamental cellular process and its nutritional outcome at the level of the multicellular plant organism. In this proposal, I aim to identify the precise roles of ubiquitination in the dynamics of plant cell-surface proteins and shed light on the machinery driving Ub-dependent internalization and sorting in plants. This proposal is based on novel and large scale biochemical and genetic approaches in synergy with systematic use of cell biology and phenotypic analyis. This work is expect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Codimension-one properties of singularities', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Our entire scientific understanding of nature is based on various types of systems of equations (linear, polynomial, analytic, differential) and their solutions. Singularities are points of local instability of these equations that can have tremendous impact on the global behavior of solutions. Thus, singularity theory is fundamentally important for mathematics and natural sciences.For polynomial/analytic equations, the singular locus is that of failure of the manifold structure of the solution space and can be described in terms of differential forms. An main tool to study this phenomenon is desingularization which relates complicated singularities to simple ones - normal crossing divisors. Normalization is a step in this direction that removes singularities in codimension one.Codim1Sing will ultimately lead to the first simple algebraic conditions characterizing normal crossing properties. To this end, a widely laid-out research project will be completed: Kyoji Saito's theory of logarithmic forms will be embedded into the theory of regular differential forms of Kersken and Kunz/Waldi and generalized beyond the hypersurface case, including the concept of free divisors crucial in singularity theory. In the process, Codim1Sing discovers the geometric meaning of deep algebraic conditions in terms of regular differential forms and (natural partial) normalizations. The project's innovative results include generalizations of the Le-Saito theorem, a proof of Faber's conjecture, as well as novel insights in the geometry of free divisors and in Vasconcelos' normalization algorithm.Codim1Sing addresses fundamental constructions and objects in singularity theory and it advances long-term collaborations between experts in Europe and worldwide, notably North America. Consequently,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Concept of fully hydraulic-mechanical shock absorber system sensitive to load, dedicated to motorcycle and of general applicability to road transport means' in the context of a Fourth Framework call.

assistant: **Objectives**

The objective of the project is the obtention of Rear shock-absorber for road vehicles, and motorcycles in particular, featured by variable hydraulic and automatic self-adjusting calibration related to the transported load and, whenever possible, sensitive to acceleration. The aim of the research consists in the development of a technology able to supply a self-powered trim control and an advanced shock absorbition law that does not need any computer-aided device or a hydraulic power supply external to the shock absorber. Obtention of Rear shock-absorber for road vehicles, and motor-cycles in particular, featured by variable hydraulic and automatic self-adjusting calibration related to the transported load and sensitive to acceleration. In particular future Brite - Euram collaborative research project intends to develop a technology based on the: - automation of load variation on the suspension by pneumatic set of pre-load (in motor-cycles the purpose is to optimise the front - back trim); - automatic hardening of the suspension according to the weight; - whenever possible, development, and coupling to the above principles, of a suspension sensitive to the vehicle acceleration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Governing ResOurce UrbanisaTion (GROUT): Multi-stakeholder governance of extractive industries in the era of planetary urbanisation' (GROUT) targeting Horizon 2020.

assistant: **Abstract**

GROUT will address the governance challenges posed by mining projects advancing close to urban areas. Europe is making a concerted effort to increase a sustainable supply of minerals from European sources, This project will improve knowledge and expertise on the governance of these urbanising frontiers. This fellowship will be carried out in the Centre for Social Responsibility in Mining (CSRM) at University of Queensland (UQ), Australia, under the supervision of Dr. Jo-Anne Everingham, expert in governance studies. After two years I will return to the Institute of Science and Environmental Technology at the Autonomous University of Barcelona (ICTA-UAB), Spain, under the supervision of Prof. Isabelle Anguelovski, head of the Lab for Urban Environmental Justice and Sustainability. Through the study of a Coal Seam Gas extraction project in the outskirts of Sydney I will innovatively combine qualitative (in-depth interviews and participant observation) and participative (World Cafe) methodologies to analyse the transformations of subjects and institutions through the analysis of power relations and environmental justice. By bringing together the inter-disciplinary fields of political ecology of extractive industries (my own expertise) with resource governance and critical urban studies (training plan) I will advance theory and analysis in the new theoretical field of Resource Urbanisation Governance (RUG). I will place special emphasis in understanding the transformations affecting women (narratives and demands, power imbalances and consequences). My training plan will include training on resource governance (at CSRM), critical urban-studies (at ICTA-UAB and UQ), Environmental Justice (ICTA-UAB and University of Sydney) and transferable skills such as gender research, faci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A disruptive innovation for the minimisation of railway maintenance costs' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Rail infrastructure managers in Europe invest yearly over €869 Million (from public funds) in repairing railway track damages caused by the poor conditions of train wheels. Nowadays, the most advanced systems to monitor the conditions of the train wheels (WID or Wheel Impact Detectors) to prevent/ minimise the damage produced to the railway track cannot anticipate accurately the occurrence of the failure or indicate to the train operating companies which maintenance operations must be performed and when it is the optimum moment. AMINSA have developed DTD System, an innovative system capable of detecting with high precision wheel defects at the onset of deterioration, and using this information to design a predictive maintenance plan. The added value of DTD SYSTEM compared to its competitors is based on:- Its superior accuracy thanks to the new filtering process carried out by its innovative analysis module (DTD system has been readily technically and operationally validated with a 99% success rate on the tracks of FGC-Spain). - Its ability to design an optimal preventive maintenance plan for wheel defects through a new software that works as a diagnosis module using artificial intelligence algorithms (train operator companies will reduce the number of failures and maintenance expenditures in their wheels by more than 20%). - Its lower price, up to 350,000 € less per unit than available WID systems in the market.DTD SYSTEM overcomes all limitations of the state-of the-art solutions available on the market, and looking at Europe only, opens the way to the market worth of nearly 61 M€In Phase 1, we will focus on the elaboration of a comprehensive business plan and establish strategic alliances with key stakeholders, ensuring a quick market deployment through the developmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Sunlight driven carbon-dioxide reduction: Hybrid catalytic systems consisting of molecular catalysts and light-harvesting Quantum-dots and semiconductors'.

assistant: **Innovation**

Artificial photosynthesis, in which sunlight is directly used to generate fuels from CO2 and water, is an attractive solution to both global energy challenges and environmental issues caused by rising CO2 levels. However, implementation of such a quasi-carbon-free fuel-economy requires efficient catalysts and light-harvester to power this uphill reaction. The proposed project is aimed at developing novel hybrid photocatalysts and photocathodes for light-induced CO2 reduction using molecular catalysts and semiconductor light-harvesters. Molecular catalysts will be immobilized onto the semiconductor-materials to generate robust photocatalysts, and subsequently, these semiconductor-catalyst assemblies will be transferred to transparent electrodes to build photoelectrodes. The innovative aspect of CO2RED is to employ inexpensive, carbon-based semi-conducting ligh-harvesters (carbon-nitride, carbon quantum dots) and 3d-metal based molecular catalysts, and use robust  linkages to interface them with transparent photoelectrodes. Finally, this hybrid photocathode will be tested in a tandem CO2/H2O photoelectrochemical cell by coupling it with a photoanode for water oxidation. The project being at the interface of synthetic, materials, photo- and electro-chemistry, will provide an excellent opportunity for the experienced researcher (ER) to develop a wide range of technical skills. In addition, the fellowship will allow the ER to gain important complementary skills including proposal writing, manuscript preparation, public outreach, networking, and IPR protection that will be invaluable for his independent career. The combination of the cutting-edge science and training excellence of the project will greatly improve the ER’s career prospect and enhance the host group’s internati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Maintenance of clonal diversity in asexual rotifer populations' (1994-1998).

assistant: **Concept**

Research objectives and content Asexually reproducing species may show considerable genetic diversity within a habitat, but little is known about the mechanisms maintaining this diversity. Coexistence of clones within a habitat may be explained by spatial heterogeneity within the habitat combined with clonal differences in drought tolerance or resource use. Alternatively, temporal shifts in key environmental factors may result in alternating dominance of clones. The planned project investigates the mechanisms maintaining clonal diversity in two species of asexual rotifers. The main questions are: 1) What is the role of spatial and temporal heterogeneity in the habitat for maintenance of clonal diversity? 2) Are the abundances and the distributions of clones in the habitat depending on their niche breadths (specialist vs generalist strategies)? The results will have implications for theories on maintenance of clonal diversity as well as for species and habitat conservation. Training content (objective, benefit and expected impact) I have made a successful start within this subject and further studies are essential if I am to use the skills and to test the ideas developed. The Centre for Population Biology has proved to be an excellent place for postdoctoral research due to its active and open atmosphere and the stay will give me the competence and the connections to act as a group leader. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'iDAPT: ice Dependent Adaptations for Plant Terrestrialization', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The evolution of a terrestrial flora from within a single fresh-water algal lineage (Streptophyta) represented a singularity in Earth’s history, giving rise to one of the most profound geobiological transitions in the history of the planet. Adaptations key for the transition from aquatic to terrestrial habitats included the ability to tolerate extremes in temperature, desiccation, and radiation; key stressors characteristic of the surfaces of glaciers, where Zygnematophycean ‘ice algae’, some of the closest living relatives to land plants, currently thrive. With this proposal, I hypothesise that glacier surfaces represent important intermediates between aquatic and terrestrial habitats, driving evolution of unique adaptations in ice algal lineages that represent exaptations of ancestral Streptophytes for the colonisation of land. To test my hypothesis, I will unite the disciplines of genomics, engineering, glaciology and biology to constrain ice algal cold-adaptation mechanisms to life in surface ice and provide unique insight into the aspects of Streptophyte biology that enabled the conquest of land. I will achieve this by i) sequencing the genomes of two ice environment specialists that dominate across the cryosphere, allowing identification of ice algal cold-adaptation mechanisms and homologs in extant basal land plant lineages; ii) develop a controlled environment microalgal assessment system, i.e. ‘photosynthetron’, optimised for deployment in surface ice environments in collaboration with a leading developer of high-throughput plant and algal phenotyping platforms; iii) deploy this across the cryosphere to validate cold-adaptation mechanisms identified from genome interrogation and significantly advance our understanding of how life excels within icy environments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Evaluation Practices in Financial Markets' (EPIFM), addressing dissemination and exploitation.

assistant: **Impact**

EPIFM will be a social-science (rather than, as conventionally, an economic) investigation, by a team bridging science and technology studies (STS), sociology and politics, of how professional participants in financial markets evaluate financial instruments such as shares and bonds.  These evaluation practices are crucial to the operation of financial markets (they help determine the activities to which investment capital does and does not flow, and for example played a key role in the genesis of the credit crisis), but surprisingly little is known about them.EPIFM will study evaluation practices in depth and in their technological and institutional contexts.  It will examine differences amongst how different groups of market practitioners conduct evaluation (including patterned differences that we conceptualise provisionally as ‘evaluation cultures’) and will investigate the factors that shape evaluation practices, factors that we expect to include technological change, organisational processes, external regulation and the articulation between monetary evaluation and other ‘orders of worth’.  EPIFM’s methodology will predominantly be qualitative, including semi-structured interviewing, fieldwork at finance-industry conferences and training courses, documentary analysis, and – where possible – direct observation of practices.  Amongst the phenomena EPIFM will investigate is automated trading, in which evaluation, buying and selling are delegated to (usually ultrafast) computer systems operating without direct human intervention.By achieving its objectives of understanding the patterning and the shaping of evaluation practices, EPIFM will foster the exciting new specialism of ‘social studies of finance’ and encourage a much-needed broadening and deepening of social-scien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Investigating the pathogenic mechanisms underlying TUBB2B-related brain malformations using induced pluripotent stem cells and cerebral organoids.' in the context of a Horizon 2020 call.

assistant: **Objectives**

Mutations in TUBB2B are associated with a range of malformations of cortical development: severe structural brain disorders stemming from abnormal cerebral cortex formation. Functional investigation of TUBB2B mutations will enable us to elucidate distinct pathogenic mechanisms underlying various malformations and advance our understanding of normal brain development.TUBB2B is highly expressed during embryonic brain development. It encodes a major component of microtubules (MTs), which perform essential roles during neuronal proliferation, neuronal migration and cortical organisation. I have obtained preliminary data in non-neuronal cells that suggests certain (but not all) TUBB2B-related malformations result from impaired cell division during neurogenesis. This highlights a potential disease-specific mechanism. I will investigate this hypothesis using state-of-the-art induced pluripotent stem cells (iPSCs) and cerebral organoid (COs) technologies, more relevant to brain development.I will generate iPSCs from fibroblasts obtained from patients with specific TUBB2B genotypes and brain phenotypes. I will use CRISPR/Cas9 genome editing to generate isogenic controls (in addition to a generic wild type line). Mutant and control iPSCs will be differentiated into a neural lineage to study effects of mutations on cell cycle and MT dynamics. Subsequently, differentiated cells will be aggregated into COs; self-organising ‘mini-brains’ that recapitulate human brain development and disease. I will employ immunohistochemistry and microscopy to examine TUBB2B mutation effects on neuronal proliferation, migration and organisation.I will hosted by Dr David Keays (IMP, Vienna). His lab are global leaders in tubulin-gene research and work in close collaboration with the pioneers in CO tec