RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Optimization of stone processing using diamond tools' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The global market for polished stone materials has increased significantly over the last two decades with some of the non EU countries progressively enhancing their share of the market. Significant advances have been made in technology in this sector in terms of improved extractive and transformative machinery, increased automation and introduction of diamond tools in the earlier stages of stone extraction and sawing. However, the state of the diamond tool technology for grinding and polishing is still in its infancy and the diamond tools are finding a limited use on the machines which are designed primarily for conventional abrasives and therefore lack the necessary capability for full exploitation of the advantages offered by the use of diamond tools. Also machine operation is based on operator skill and experience rather than objective assessment of the raw materials and the required product quality. This together with the absence of adequate condition monitoring and automatic control lead into non-optimal conditions which result in excessive costs and rejects. The proposed research is directed at developing cost effective diamond tools for use with multihead stone processing machines for grinding and polishing of natural stone materials. The project also aims to determine the machine tool characteristics required for maximising the advantages offerd by diamond tools, culminating in the design of a prototype machine with appropriate dynamics incorporating the necessary systems for monitoring and control of processing parameter. To achieve optimal tool and machine perfomance in terms of cost and product quality, a precise knowledge of raw material properties related to grinding and polishing is needed to allow an objective determination of machine and tool parameters,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'INTERCONNECTED EUROPEAN INNOVATION ECOSYSTEMS FOR SUSTAINABLE GROWTH AND DEVELOPMENT' to be submitted under Horizon Europe.

assistant: **Abstract**

Rural innovation ecosystems refer to the networks of individuals, organizations, and institutions in rural areas that work together to foster innovation, entrepreneurship, and economic development. In a rural innovation ecosystem, these actors collaborate to identify and develop new ideas, products, and services that address local challenges and opportunities. Successful rural innovation ecosystems typically have several key characteristics, including strong community engagement, supportive policies and regulations, access to capital and resources, and a culture of experimentation and learning. InnovationGUIDE objectives closely align with the European Commission Communication on a New European Innovation Agenda objectives by increasing the inclusion and interconnection of less represented regions and actors into a more strongly integrated European ecosystem.With this starting point InnovationGUIDE designed to pinpoint regional needs and possibilities for connecting them into international ecosystem which can be a driver of regional economic development, attract and retain talent, build local businesses, and create new jobs and industries.InnovationGUIDE will use 12 months to map the geography covered by the partners and design roadmaps and bi-annual plans for future to serve rural communities overcoming the disparities with proper services and activities compared to urban ecosystems. InnovationGUIDE will have a focus for policymakers, researchers, and practitioners interested in promoting sustainable, inclusive economic growth in rural areas.Connecting Dutch, Spanish, Maltese and Turkish experience and ecosystems InnovationGUIDE will enable information and knowledge diffusion from stronger innovator ecosystems to moderate innovator ecosystems.


**Keywords:** rural inn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Towards an improved risk assessment of the contaminant spreading in factured underground reservoirs' under Fifth Framework.

assistant: **Concept**

Problems to be solvedThe soil and groundwater contamination by hazardous substances tends to become one of the most significant problems for the environmental and economic policies of the European Union (EU). Macroscopic simulators of the transport of non-aqueous phase liquids (NAPLs) in fractured porous media are required for the implementation of fast and cost-effective risk assessment procedures to contaminated fractured sites. In spite of the progress that has been accomplished on the development of intelligent numerical solvers of the multiphase transport equations in fractured reservoirs, there is a lack of fundamental knowledge concerning the relations of the flow physics with the complex morphology of fractures as well as of self-consistent phenomenological models of the mesoscopic transport coefficients (e.g. absolute permeability, relative permeabilities, hydrodynamic dispersivities) of fractured media.Such models, properly integrated into industrial macroscopic simulators, are required for the development of generalized, cost-effective and reliable risk assessment methodologies, which are expected to contribute to:(i) the mapping of the huge number of contaminated sites in EU,(ii) the rational design of clean-up strategies for the contaminated aquifers of EU, and(iii) the development of new EU-policies about the sustainable management of soils as natural resources.Scientific objectives and approachThe overall objective of the project is threefold:(a) to develop new, self-consistent and true-to-mechanism phenomenological models to describe the transport coefficients of fractured porous media as functions of the fracture morphology and fluid rheology,(b) to integrate the new phenomenological models into a novel and reliable numerical simulator of the macroscopi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Capital Science: Meet your local researcher at Bern's first Researchers' Night' to be submitted under Seventh Framework.

assistant: **Abstract**

Capital Science will attract a large and diverse audience to a unique event celebrating research and researchers in the heart of the capital city of Switzerland. With a rich and vibrant programme the first researcher’s night in Bern will provide many different opportunities for the audience to personally meet researchers from all disciplines. The event will help overcome public stereotypes of researchers and inspire the young to consider research as an option for their own career. Capital Science will build on the success of two large festivals that were celebrated in 2009 on the occasion of the 175th anniversary of the University of Bern. These two previous events assembled each 200 researchers and 10’000-15’000 visitors and generated more than 20 contributions in the national media, thereby vividly demonstrating the creative, organisational and logistic capacities of the organisers and the keen interest of the public at large as well as the local and national media.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Explaining Politicians' and Voters' Behavior' (POLITICALMIND).

assistant: **Concept**

Theoretical models and empirical studies in political economy aim at explaining both the beliefs and the choices of voters and politicians, so as to assess their impact on economic policy. In particular, a recent literature has recognized the crucial relevance of the identity of politicians in taking policy decisions and ultimately in shaping the fate of their country (Besley 2005; Jones and Olken 2005). In this project, we will address two neglected elements in the existing literature: the role of political parties as organizational structures that shape political careers (i.e., who gets on top in democracies); and the nature of social preferences, personality traits, and cognitive biases in understanding the beliefs and the choices of both politicians and voters.To make this research agenda operational, we will cover a set of related topics, which will range from the analysis of networks and career trajectories within political parties to the impact of emotions on protests, from the cognitive biases and personality traits of elected officials to the impact of violence on long-term political attitudes, from cognitive dissonance in voting to the contamination between political and judicial elections.From a methodological perspective, the project will tackle these issues empirically by combining the collection of original individual-level datasets (mainly in Italy) with the implementation of design-based identification strategies (Angrist and Pischke 2010). In particular, based on a careful institutional analysis of the topics under investigation, the empirical strategies will range from randomized controlled trials to instrumental variables, from laboratory experiments with elected officials (i.e., taking politicians to the lab) to regression discontinuity designs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Evaluating a Combination of Immune-based Therapies to Achieve a Functional Cure of HIV Infection'.

assistant: **Concept**

The main goal of HIVACAR proposal is to change the current paradigm of HIV treatment by obtaining a functional cure for HIV (i.e., control of viral load to levels below the threshold of 50 copies/ml and maintenance of high CD4+ T-cell count after discontinuation of antiretroviral therapy) thanks to effectively targeting residual virus replication and viral reservoirs. In order to do so, the planned novel strategy is to successfully combine immune-based therapies, including therapeutic vaccines and broadly neutralizing antibodies with latency reversing agents, in a proof-of-concept phase IIa clinical trial. HIVACAR project will lead to a reduction of the actual costs related to HIV treatment and management and of the social public health as well as an improvement in the patients’ quality of life. HIVACAR project has been conceived under the framework of responsible research and innovation, so patients and other stakeholders will have a key role from the inception of the project until obtaining the results. Patients will be perfectly aware of how this therapy has been conceived and the real impact and change in their actual quality of life, as well as how the clinical trial has been designed and the consequences of participating in it. In addition, patients (and the general population) will tailor the project and its results dissemination and communication. This patient engagement will not be limited to the clinical trial but also to the rest of the activities of the project, so patients and the general society will be aware of how the research is developed and can include the patients’ point of view in the research activities. In addition, the socio-economic and psycho-social impact of the new treatment will be also analysed so overwhelming data on the benefits and impac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ophthalmic OCT on a Chip' under Horizon 2020.

assistant: **Concept**

Silicon photonics is expected to leverage-off many of the advances made in CMOS electronics. International R&D efforts in this field have so far been mainly focused on the silicon-on-insulator (SOI) photonic integrated circuit (PIC) technology platform because it is predestined for datacom, high-performance computing and telecom applications. However, SOI based integrated optical waveguides cannot be used for the VIS/NIR <1.1µm wavelength region, which is important for life sciences and health related applications and, thus, offers a huge potential for PIC technology. To this end, a novel CMOS compatible low-loss silicon nitride waveguide based PIC technology platform will be developed in OCTCHIP and directly applied to the a strong business case in the field of optical coherence tomography (OCT) for ophthalmology.OCT is a revolutionizing in-vivo 3D imaging technique for non-invasive optical biopsy addressing medical needs with early diagnosis and reduction of healthcare cost. OCT has proven its value primarily in ophthalmology and cardiology but recently also in a variety of other medical fields. However, wide adoption has not taken place due to size and cost limitations as well as non-existence of miniaturized devices. The PIC technology developed in OCTCHIP will make a new generation of OCT systems possible with step-changes in size and cost beyond state-of-the-art. The monolithic integration of silicon nitride optical waveguides, silicon photodiodes and electronics combined with the hybrid integration of a III-V laser source will enable a compact, low-cost and maintenance free solution. OCTCHIP will contribute to radically transform OCT towards widespread adoption in point-of-care diagnostics for the early diagnosis of retinal pathologies, which are leading causes f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Research Infrastructures Consortium for Horizon 2020' (RICH) under Horizon 2020.

assistant: **Objectives**

The National Contact Points perform valuable services in guiding and supporting national applicants in preparing proposals for Horizon 2020 funding. We expect that through an enhanced transnational cooperation and networking between National Contact Points for research infrastructures, a higher quality of their consulting services and thus of proposals and projects can be achieved. Therefore, the specific objective of RICH (Research Infrastructures COnsortium for Horizon 2020) is to facilitate trans-national co-operation between NCPs for research infrastructures with a view to identifying and sharing good practices and raising the general standard of support to programme applicants, taking into account the diversity of actors that make up the constituency of the Research Infrastructures Part.By involving 11 formally nominated National Contact Points RICH will be able to  will extensively involve the NCPs that have decided to become “associated partner” also thanks to the setting up of a liaison office.Concretely, activities of RICH towards this goal include, amongst others, multi-level trainings and tripling schemes, experts seminars, simposia and wide promotion of Transnational Access and Service (TAS) as well as a wide range of other communication and dissemination tools and platforms.RICH work programme is designed to achieve an improved and professionalised NCP service across Europe, thereby helping simplify access to Horizon 2020 calls, lowering the entry barriers for newcomers, and raising the average quality of proposals submitted.


**Keywords:** National Contact Point, Research Infrastructures, E-infrastructures, network
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New targets for anti-hiv therapy: entry and integration' to be submitted under Fifth Framework.

assistant: **Abstract**

Four predoctoral positions (6 months - 1 year) are available to perform research as part of a doctoral thesis in the Anti-HIV Therapy Group of the Rega Institute of the KU Leuven, Belgium. This group aims at developing new antiviral compounds for the treatment of AIDS patients. The Rega Institute has a world-wide reputation in AIDS research, especially in antiviral drug design, in determination of the mechanism of anti- HIV action of new compounds and in evaluation and follow up of development of in vitro resistance. Recently our research effort has focused on new antiviral targets, namely HN entry and integration. Doctoral research students who have synthesized new compounds can benefit to great extent from the possibility to evaluate the potential inhibitory effect of their compounds against the replication of HIV in cell culture. Students who study compounds with known anti-HIV activity can profit from the identification of the mechanism of action of their compound. Students who study viral entry or viral integration or antiviral drug resistance in general can use our wide collection of established drugs and HIV strains as well as our proprietary novel technology focusing on HIV entry or integration. Doctoral students will be trained in the different aspects of HIV research and anti- HIV chemotherapy. Special attention will be given to the biosafety training (BL-3 for infectious HIV cell culture work). Skills and techniques trained include: cell culture work; virology (titration, microscopy of cytopathic effect, ultra-centrifugation, time-of -addition experiments, drug-resistance selection, p24 ELISA); and chimeric virus technology (CVT) to elucidate the gene responsible for the reduced sensitivity of the selected strain (cloning, PCR, sequencing, transfection). Stud
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Modulating Tregs in liver disease for therapeutic benefit' to be submitted under Horizon Europe.

assistant: **Abstract**

Regulatory T cells (Tregs) are important for maintaining tolerance to self and are known to contribute to appropriate priming in the case of foreign challenges, however, their role in liver homeostasis and disease remains to be determined. Liver disease represents a significant global health issue with Hepatitis B Virus (HBV), Metabolic dysfunction-associated Steatotic Liver Disease (MASLD), and Hepatocellular Carcinoma (HCC) resulting in considerable morbidity and mortality worldwide and limited treatments are available to address these conditions. This project aims to identify novel mechanisms of targeting Tregs in liver disease to suggest methods to manipulate these cells for therapeutic benefit. Cutting-edge mouse models of HBV, MASLD, and HCC will be used to determine the phenotypes, kinetics, and localisation of Tregs in the liver under homeostasis and during disease. High parameter flow cytometry, spatial transcriptomics, and state-of-the-art intravital imaging will allow us to investigate high-resolution spatiotemporal dynamics of liver Tregs to identify novel molecules, interactions, and functions of these cells. Tissue samples from human patient HBV and HCC cohorts are available to the host lab and can be used to screen and refine the molecules of interest identified in mouse liver Tregs to focus further investigation on clinically relevant molecules. The role of Tregs in T cell priming in HBV, and effects on MASLD progression, and HCC development will be determined using mouse models to specifically deplete Tregs, or delete molecules of interest in Tregs, at defined disease stages. Overall, this project will significantly advance our understanding of Tregs in the liver and has the potential to reveal promising clinical targets. The training in experimental te