RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Impact of stress-induced transposon activities on human disease' (TRANSPOSOSTRESS) under Seventh Framework.

assistant: **Objectives**

The evolutionary success of transposable elements (TEs) is underscored by the finding that about 45% of the human genome is TE-derived. However, recent high throughput approach studies indicate that the impact of TE-associated activities was seriously underestimated. The first objective is to investigate the impact of TE-derived activities on the human genome in general and on disease mechanisms in particular, based on the central premise that some of these activities are stress-induced. To model how a vertebrate-specific transposon responds to stress signals in human cells, I will study molecular interactions of the Sleeping Beauty (SB) transposon with host cellular mechanisms to understand how stress-signalling and response triggers transposon activation. My second aim is to decipher the relationship between stress-induced activation of endogenous TEs and TE-derived regulatory sequences and human disease. I aim at investigating conditions and the consequences of activation of a particular copy of the MERmaid transposon located in the Sin3B transcriptional corepressor, frequently observed in cancer. The impact of global epigenetic remodelling will be investigated in the model of a complete (induced pluripotency) and partial (trans-differentiation) epigenetic reprogramming. In parallel, I aim at translating experience accumulated in TE research to cutting-edge technologies. First, the SB transposon will be adopted as a safe, therapeutic vector to treat age-dependent blindness (AMD). Second, a mutagenic SB vector will be used in a forward genetic screen to decipher a genetic network that protects against hormone-induced mammary cancer. The anticipated output of my research programme is a refined understanding of the consequences of environmental stress on our genome medi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The TENTORTUBE: an innovative improvement of a passive tip mechanism' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Objectives Most present wind turbines are equipped with actively controlled tips as a safety system. For variable speed wind turbines passive controlled tips can be utilised for both power control and as a safety system, as has been demonstrated on a rotor equipped with a tip mechanism, consisting of a metal screw cylinder and a spring. The main problems with this mechanism are the large mass and complexity and high maintenance costs, but these can be solved with a TenTorTube combining the functions of the spring and the screw cylinder. The TenTorTube is a long, slender tube made of composite material in which the anisotropic behaviour of fibre reinforced material is utilised. The objective is to reach an aeroelastic stable configuration of a blade with a TenTorTube tip mechanism and to deliver reliable information on its costs and applicability. Technical Approach For rotor structures with a low torsional frequency aeroelastic stability is a potential problem which may lead to blade loss. For a TenTorTube blade an additional coupling occurs. The aeroelastic behaviour will be evaluated using available prediction tools in terms of aeroelastic stability boundaries. From this information a wind tunnel test specimen will be specified and manufactured and a test plan will be formulated to explore the boundaries. During the test different parameters will be varied to define their influence. This may be followed by improvements of the prediction codes and, if necessary, additional tests. The full scale blade and TenTorTube will be designed to meet the draft IEC regulations. After manufacturing acceptance tests will be carried out to ensure the functionality and safety of the rotor configuration. During the full scale test different properties will be monitored to enable evalua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innovative mixed-anion approach to design materials with optical and selective ionic conduction properties' in the context of a Horizon 2020 call.

assistant: **Objectives**

Because the Earth’s atmosphere contains mainly reactive oxygen (and inert nitrogen), conventional inorganic syntheticmaterials are mostly oxides. From the research point of view, the 20th century was a prosperous era in the field of solid-statechemistry with discoveries of many inorganic oxide compounds that laid strong foundations of materials synthesis andcharacterization. The impressive development of oxides followed by other single-anion compounds, such as fluorides,nitrides, and chlorides is mainly due to their stability and ease of synthesis. Nevertheless, after a century of intensiveresearch both conventional solid-state techniques and numerous combinations of metals (or cations) are reaching a pointwhere they have been exhausted, which makes further development of new single-anion inorganic materials more and moredifficult. Consequently, today, compounds with multiple anions beyond the single-oxide ion composition, offer a newplayground for materials development where greater functionality can be found. Besides, unlike oxides, which exhibitchemistry and structures often known from mineralogy, the structures of most mixed-anion compounds are yet less exploredwith much more to learn.The aim of this project it to show how the mixed-anion approach will be beneficial to many fields of solid-state chemistry andhow the candidate and the host researcher will apply it to the topics tackled by the host group: materials with opticalproperties and selective ionic conductivity. On the one hand, the candidate experience in oxide-derived materials and on theother hand, the host researcher expertise in the fluorine-derived materials will allow a broad prospection of new compoundsand consequently functional materials with new properties. Finally, the combined efforts of the cand
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Welfare and individual choice when identity matters'.

assistant: **Innovation**

On one hand, economics can be defined as the study of efficient resource allocation to alternative ends. On the other hand, economics can be defined as the study of rational choices. However, these two views of economics go hand in hand: the evaluation of efficient resource allocation is based on the idea of the economic agents' rational choices and both rely on the assumption that people have unchanging preferences over time. Current researches in experimental economics show however that people violate fundamental axioms that are at the basis of rational choice theory (RCT) and that their preferences change over time. In this line, philosophy, cognitive studies, psychology and sociology demonstrate that people's choices can be motivated by other than standard RCT.Behavioural economics now tries to respond to some of these results by offering a modified theoretical and rational account of human behaviour. Yet, by doing this, behavioural economists fall from a single-and-unchanged-preference-conception" to the other extreme of a "multiple" or "hierarchical-self-conception". The individual then turns out to be equilibrium of competing interests. The question thus is what becomes of welfare evaluations with this modified rationality and conception of the in dividual? I propose to consider individual choice and welfare evaluations when preferences change. However, I will base my considerations on the philosophical conception of personal identity introduced in an economic context.The advantage of these philosophical considerations is that it reintroduces a coherent conception of an individual over time that explains how people change without becoming multiple. This will be an extension of my PhD, where I developed a "model of identity" that allows seeing the economic agent a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'PRECISION CARE IN SYSTEMIC AUTOIMMUNITY: AN INTEGRATED MULTI-TISSUE/LEVEL APPROACH FOR SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)'.

assistant: **Concept**

Systemic lupus erythematosus (SLE) is a heterogeneous disease whereby an interplay of environmental, genetic and epigenetic factors lead to perturbation of complex biological networks culminating into diverse clinical phenotypes of varying severity. High throughput methods have allowed an “initial glimpse” into pathogenesis and have laid the foundations for a molecular-based taxonomy for personalized therapy. Based on our experience with the molecular characterization of SLE, a recently completed RNA sequencing analysis of 150 patients, and our track- record of “paradigm shift” trials in SLE, we will integrate data from multi-tissue analyses with novel technologies to improve its diagnosis, monitoring and therapy, and ask fundamental pathogenetic questions in systemic autoimmunity. More specifically, we will design gene expression panels and “expression profile”/”clinical trait” correlation matrices for diagnostics, personalized immunotherapy and improved clinical trial design. In a systematic multi-tissue approach, we will examine the role of somatic mutations in enhancing immune hyperactivity and the risk for lymphoma. The staggering (7-9:1) female predominance will be elucidated through elaborate genomic, epigenomic and microbiota analyses of family trios. Finally, we will be pursuing the innovative hypothesis that the fundamental abnormalities of SLE lie within the bone marrow hematopoietic stem cells (HSCs) - from which all cells that participate in the pathogenesis of SLE originate - and establish it as a unifying pathogenetic mechanism. By a combination of novel experimental analyses with single cell genomics, multi–omics, humanized animal models, genome editing and an “organ on-a-chip” device, we will validate HSCs as a therapeutic target. The utility of SLE res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Magnetically actuated bio-inspired metamaterials'.

assistant: **Innovation**

This project will deliver a new class of metamaterials whose functionality can be controlled by external magnetic fields. The materials consist of micromotors, comprising an anisotropically “hard” and “soft” ferromagnetic particle pair embedded in a polymer matrix, and promise wide-ranging technological applications. The project, involves 5 partners with expertise in experimental and theoretical physics, biological science and technology. Building upon a detailed analysis of the physical properties of the individual motors, and their dependency on their magnetic and material properties, the team will develop methods for incorporating the motors into elastic membranes (MEMs). We shall analyse the mechanical and optical properties of these constructs and the ways in which they can be modulated by the external magnetic fields. These novel properties will then be used to produce prototype devices: • Pumps for fluids and tuneable filters for dissolved solutes, operating down to microscopic length scales and based on magnetically driven membrane deformation and changes in internal pore structure.• Tuneable optical devices such as lenses and filters based on magnetic strain-induced changes in the optical and photonic properties of the constructs.• Substrates for biotechnology, tissue engineering and regenerative medicine. These devices will be based on our ability to apply to cells in culture the patterns of temporally and spatially varying strain fields to which they are exposed in vivo and which maintain their phenotype and metabolic activity.The prototypes will find immediate applications in expanding areas of technology ranging from lab-on-a-chip systems to biomedical implants. They will also help the team to develop a thorough understanding of the novel emergent propertie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Janus Graphene supported Single atom catalysts for ultrasensitive cytokine point of care sensors' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Cytokines, such as TNF-α, hold immense significance as protein biomarkers, pivotal for diagnostic, prognostic, and therapeutic management across various clinical disorders like Alzheimer’s disease, sepsis, and cancer. Nonetheless, prevailing techniques like enzyme-linked immunosorbent assay (ELISA) and Polymerase Chain Reaction (PCR) prove to be expensive, time-intensive, and reliant on specialized personnel, intricate instrumentation, and infrastructure. Furthermore, the performance of present biosensing techniques necessitates refinements in terms of real-time outcomes, sensitivity, affordability, and user-friendliness. Within this context, the RESPONSE project sets out to forge an innovative approach, intertwining Janus graphene derivatives (JGDs) and Single Atom Catalysts (SACs), or atozymes, for Point-Of-Care (POC) biosensors for cytokine detection. This undertaking involves the strategic utilization of selectively and densely functionalized JGDs, serving dual roles: i) as signal transducer immobilized on a paper lateral flow electrochemical sensor (LFES), and carrying the cytokine bioreceptor (primary/capture antibody; Ab1) and ii) as signal amplifier JGDs, housing the SACs and the secondary/signal antibody (Ab2), which binds to a different epitope of cytokine. The binding between TNF-α and JGDs-Ab1 initiates the sandwich formation with SAC-JGDs-Ab2 complex at the test region. Here, the SACs catalyze the oxidation of an appropriate reporter molecule, liberating electrons and thereby significantly amplifying the signal output which can be quantified through an integrated electrode system. REPSONSE offers affordability, point of care readiness and commercialization potential. Importantly, RESPONSE’s strategy defines the blueprint for transitioning from the current,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Materialities of Operatic Performance in Risorgimento Italy' (MOPRITALY).

assistant: **Concept**

MOPRITALY examines the wide range of new theatrical practices shaping Italian opera in the period 1815-1861: from stage technologies and stage manuals, to transformed architectural spaces, to newly powerful voices and orchestras. Italian opera at this time has long been studied in relation to the political upheavals surrounding Italian unification. MOPRITALY instead offers a new history of modern operatic performance, highlighting Italian opera's role in shaping wider experiences of modernity within Italy and abroad. In so doing, the project develops a more sophisticated framework for exploring the relationships between opera, aesthetics and politics, and defines a new role for Italian opera in narratives of modern European and Western history, by interrogating opera's relationship with broader social, cultural and technological developments. MOPRITALY achieves these objectives by concentrating on Rome, Naples, Venice, Florence and Milan - key centres of theatrical innovation - and drawing upon a wide range of archival sources: from operatic scores and libretti, staging manuals, acting guides, singing treatises, press reviews and letters, to institutional records, political tracts, scientific and medical treatises, and memoirs of the spoken theatre. The project will be carried out at La Sapienza (Rome), an outstanding international centre for musicology and ideally placed for archival work throughout Italy. MOPRITALY will be supervised by Professor Emanuele Senici, a renowned expert on nineteenth-century Italian opera, and it includes a six-month placement at the Archivio Storico Ricordi (housed at the Biblioteca Nazionale Braidense) that will support implementation of earlier research findings. MOPRITALY will overall transform my research skills and professional networ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'TCBL – Textile and Clothing Business Labs Transformative Business Models for the Textile Clothing Sector' (TCBL) under Horizon 2020.

assistant: **Objectives**

TCBL uses Europe’s Textiles & Clothing (T&C) industry as test beds for evolutionary-driven co-design, dynamic optimisation and deployment of business models. It aims to increase the performance of a sector that, over the past two decades, upheld three main strategies to handle global competitive pressure: cost-oriented, product/service-oriented and productivity-oriented. TCBL provides a business experimentation framework for exploring variations on such strategies. The framework will be supported by Knowledge Spaces as a generative force and Business Services as an enabling force. A network of Business Labs will be set up, based on three key variations: Design Labs (e.g. creating emotionally-oriented immaterial value), Making Labs (e.g. converting skilled labour into material value), and Place Labs (e.g. generating spatial community- and socially- oriented value). Each of these Labs will explore the issues of cost, product/service and productivity enhancement in a transversal manner and from cross-disciplinary perspectives - including economic, anthropological, and engineering approaches as well as new business values such as environmental and social responsibility, sharing economy, social enterprising, customer-driven small series production (the focus of this call) and emergent or disruptive technologies. With these tools, and supported by an open Associates Programme, TCBL will carry out real-life experimentation and market deployment of a number of Supply Chain, Localisation, Business, Skill Management and Policy innovations involving no fewer than 160 workshops, laboratories and manufacturing plants at EU level with at least 15,000 T&C workers involved. In addition, 10 new innovative companies will be generated within the supply chain of T&C, enabling the diffusion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'How plant cells set the tempo of rhythmic shoot construction'.

assistant: **Innovation**

Time is central to the development of the body plan of multicellular organisms. One prominent developmental timing mechanism is the rhythmic, iterative addition of tissues and organs. While the tempo of rhythmic construction is often set by developmental clocks, plants use a unique mechanism in the shoot, whereby rhythmic organogenesis emerges from dynamic changes in the distribution of the hormone auxin. High auxin levels trigger organogenesis but, contrary to a long-standing theory, the period of shoot organ production - or plastochron - cannot simply be encoded in periodic auxin oscillations, due to noise in these oscillations. Revealing how the tempo of shoot construction is established thus remains a critical knowledge gap in plant biology.In TEMPO, we hypothesize that cells record and use the history of their auxin exposure, in order to robustly set the timing of organogenesis and the plastochron at the tissue scale despite noisy auxin temporal information. This fundamental change in the way we understand the relationship between auxin and the plastochron stems from preliminary data from my team suggesting histone acetylation as an epigenetic-tracking mechanism, which allows auxin temporal information to be recorded and utilized for transcriptional control.Uncovering how auxin temporal information establishes the tempo of shoot construction requires multiscale, multidisciplinary approaches. We will combine cutting-edge live-imaging, synthetic biology and computational modeling with innovative optogenetics and single-cell genomics to both ascertain and perturb auxin temporal information and histone acetylation at high resolution, while assessing the effect on cellular transcriptional states and the timing of organ production. Beyond testing whether epigenetic track