RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'No country for old sperm: male aging, sperm aging, and external stressors as determinants of sperm quality and fertility' (SPERMAGE).

assistant: **Concept**

Deterioration in sperm quality with age is a major cause of male infertility. This has particular socio-economic relevance for Europe where fatherhood is increasingly delayed and infertility has reached near epidemic levels, costing the EU  €4 billion per annum. The mechanisms causing, and the full consequences of declining sperm quality with age remain very poorly understood. For example, it is unclear how much of the reduction in sperm quality is due to advanced male age or the time sperm are stored within males reproductive organs, and we do not understand the mechanisms responsible for deteriorating sperm quality with increasing male age. The general aim of this project is to disentangle the effects of male aging and sperm aging on sperm quality, fertility and reproductive fitness using Drosophila melanogaster as a model. We will also test putative mechanisms thought to cause age-related fertility declines and test two possible general pathways through which sperm age. This proposal is a much needed integration of evolutionary ecology and sperm physiology, benefiting from the ideal match of skills and expertise of the Applicant (Tourmente - physiology), and the PI (Hosken - evolution). Since the mechanisms and phenomena studied are conserved across animals, the research proposed has high potential to produce results relevant to fundamental and applied research in human aging and reproductive health and animal breeding. The MSC fellowship will be pivotal for Applicants development toward independent research and offers the unique opportunity to work in one of the most prominent evolutionary ecology groups worldwide. The Biosciences Department at the University of Exeter is world-leading and provides excellent opportunities for the personal career development of the A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'NDTonAIR: Training Network in Non-Destructive Testing and Structural Health Monitoring of Aircraft structures' in the context of a Horizon 2020 call.

assistant: **Objectives**

The “NDTonAIR” consortium involves Universities, Research Organisations and major European companies working on new Non-Destructive Testing (NDT) and Structural Health Monitoring (SHM) techniques for aerospace, of which both are key technologies. The goal is to train a new generation of scientists and engineers with a wide background of theoretical and experimental skills, capable of developing their research and entrepreneurial activities both in academy and industry and playing an active role in promoting the importance of quality inspection and structural monitoring in aerospace components. The objective of the training programme is to provide the recruited researchers with an extensive and varied training on:  (1)  Fundamentals skills for NDT and SHM through participation in short-courses and seminars organized by the Consortium; (2) NDT and SHM Techniques for Aerospace through research training at host institutions and participation in Workshops and Conferences organized by the Consortium and major international research associations; (3) Technology Transfer and Entrepreneurship through participation in short-courses and seminars organized by the Consortium.The objective of the research programme is to consolidate and innovate current NDT and SHM techniques for Aircraft inspection by (1) investigating new physical phenomena and sensors; (2) developing analytical and numerical models to correlate the results of inspection with material properties; (3) quantifying NDT techniques through their probability of detecting reference defects; (4) developing procedures for the automatic detection and classification of defects; (5) transferring these results to industry. The members of the Consortium will work together for realizing this training programme and scientific coll
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Generalised Tree Automata, Monadic Second Order Logic and Transfer Principles in Combinatorial Limits' under Horizon 2020.

assistant: **Concept**

The project will concentrate on two main directions (MD), which are connected through them both relying on Monadic Second Order (MSO) and its variants.   (MD 1) Shelah's conjecture. In his celebrated 1975 paper Shelah proved that the monadic second order theory (MSO) of the real order is undecidable. He conjectured in his Conjecture 7B that  Conjecture: MSO of the real order where the second order quantifier ranges only over Borel sets, is decidable.  In spite of important efforts on this question in both mathematics and computer science community, the conjecture is still open. Many strategies, including the one suggested by Shelah in his paper (to use Borel determinacy) have been tried. We propose to study this question using the recent methods of the generalised descriptive set theory and the generalised automata that we intend to develop. This is novel and might lead to important advances and the solution.   (MD2) Countable combinatorial limits. Since the work of Lovasz and others in his group around 2006, a new area of discrete mathematics emerged: the combinatorial limits. This fast growing area aroused much interest and found many applications Its first development was that of a graphon, which is an uncountable limit of a sequence of finite graphs, but there have been several others. It is always important to understand the transfer properties of statements between the sequence forming the limit and the limit itself.  The question has been considered through ultrapowers and through topology and Stone's  pairings. None suffices for the transfer of MSO sentence. We propose to study that transfer through the novel notion of a countable model where the notion of satisfaction has been changed so that the countable model reflects the structure of the sequence of finite
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Disease Risk And Immune Strategies In Social Insects' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Group-living has been predicted to have opposing effects on disease risk and immune strategies. First, since repeated contacts between individuals facilitate pathogen transmission, sociality may favour high investment in personal immunity. Alternatively, because social animals can limit disease spread through collective sanitary actions (e.g., mutual grooming) or organisational features (e.g., division of the group’s social network into distinct subsets), sociality may instead favour low investment in personal immunity. The overall goal of this project is to experimentally test these conflicting predictions in ants using advanced data collection and analytical tools. I will first quantify the effect of social organisation on disease transmission using a combination of automated behavioural tracking, social network analysis, and empirical tracking of transmission markers (fluorescent beads). Experimental network manipulations and controlled disease seeding by a robotic ant will allow key predictions from network epidemiology to be tested, with broad implications for disease management strategies. I will then study the effect of colony size on social network structure and disease transmission, and how this in turn affects investment in personal immunity. This will shed light on far-reaching hypotheses about the effect of group size on social organisation ('size-complexity’ hypothesis) and immune investment (‘density-dependent prophylaxis’). Finally, I will explore whether prolonged pathogen pressure induces colonies to reinforce the transmission-inhibiting aspects of their social organisation (e.g., colony fragmentation) or to invest more in personal immunity. This project will represent the first empirical investigation of the role of social organisation in disease risk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Digital radio game changer' (DABCAST), addressing dissemination and exploitation.

assistant: **Impact**

Terrestrial broadcasting digitization is an ongoing process – television across Europe has been already switched to digital standard. Digitization of radio is next step and EU has already recommended the standard for it: DAB+. It gives great benefits to both listeners and radio stations (broadcasters), including better sound, rich content (visuals, text, web contents) and more radio stations available.Despite recommendation is already 10+ years old, the transition process was so far very slow (only Norway decided to switch over to DAB+ signal in 2017). The reason is that broadcasters are reluctant to carry high costs of this transition. It is unbearable especially for Small and Medium Broadcasting (SMB) stations, with limited budgets and resources to handle the expensiveness and complexity of digital broadcasting.To address this market niche, BCAST has invented the first ever complete digital transmission service in the cloud, called DABCAST. It hides all the complexity of DAB+ transmission (from studio down to transmitters and antennas) behind single service, being also cheaper than traditional DAB+ installations and offering added services available only in expensive products, e.g. content preparation software, monitoring and quality assurance tools.This remarkable characteristics were only possible to achieve by combining technological innovation with market position and business resources of BCAST company. As one of three Polish broadcasting operators (one of 50 on European scale), we provide transmission services to broadcasting stations, both analog and digital. We own and expand continuously our transmission network (antennas and transmitters). With DABCAST we plan to further utilize it to serve SMBs digitization.The objectives of this project are to finalize the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bio-Orthogonal Chemo-Specific Ligation' (BIOCHEMLIG).

assistant: **Concept**

The Post-genomic era calls for a deep understanding of protein structure and function. The elucidation of protein structures, localization, post-translation modifications, and protein-macromolecule interactions are important to establish their role in the biology of the cell. To establish their role and investigate the protein functions requires the integration of various complementary disciplines. Among all disciplines, chemistry is central in establishing new effective ways to manipulate a biological entity to understand cellular processes with molecular precision. For studying, analyzing and manipulating a macromolecule, the site-specific incorporation of reporter molecules, by virtue of ligation reactions, is a key factor. The BioChemLig research project presented herein describes novel approaches for the discovery of new bio-compatible and chemo-specific ligation reactions. The aim of this project is to develop new ligation processes with high efficiency, large scope of application, high chemoselectivity and high rates. Through a well established network, with demonstrated success (IBAAC Project: FP6-505020), we propose to focus our efforts in a highly combined and integrated training research action conducting research and using: unusual organic chemical functionalities for ligation, environmentally benign “on water” ligation reactions, specific 18F radiolabelled reagents, dendrimers conjugation methodologies, high-throughput screening for bond forming reactions, bio-chemo informatics platform for theoretical investigations, artificial metalo-enzymes for template-directed ligation, templated ligation reactions and HTS. This high quality integrated research should ultimately allow scientists to dissect cellular processes with molecular precision, speed up preparati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Pan-European Food Systems Science Network' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The vision of FoSSNet is a strengthened and deepened academic network to support a new Knowledge and Innovation governance structure for Europe’s food system. A new structure is needed as the current Knowledge and Innovation system in the European Research Area is insufficient to address the emerging challenges of nourishing the European food system in a healthy, sustainable and fair way. The aim of FoSSNet is twofold, on one hand to establish a permanent pan-European network for Food System Science and on the other hand to advance inter- and transdisciplinary Food System Science and education. This will contribute directly to the farm to fork objectives and FOOD2030 priorities. Developing the network and advancing Food Systems Science and education will be underpinned by an inclusive approach to ensure engagement of all relevant disciplines, researchers and non-academic actors in advancing Food System Science. In order to reach the vision and aim, FoSSNet will 1) develop a conceptual framework and a process for developing food system transformation pathways to create a common language and understanding among food system thinkers, 2) establish, mobilise and consolidate an inclusive inter- and transdisciplinary pan-European academic network for food systems science to bring European food systems scientists and the science institutions together, 3) enhance inclusivity of the Knowledge and Innovation system for a sustainability transformation of EU food systems by addressing sensitivities to power relations and inequities that pervade food systems and contested transformation processes, 4) co-produce research for sustainable food system transformation to remove existing barriers to interdisciplinarity in food system science, 5) build food systems capability through an acad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Dynamic and Mechanical Role of Spectrin in Membrane-Cytoskeleton Interplay'.

assistant: **Concept**

Multicellular organisms have evolved complex mechanisms to sense and adapt to the surrounding environment by dynamically controlling cell shape and exert forces. While the most studied mechanisms are the Actin and Microtubule networks, there is poor understanding of a third system called Intermediate Filaments. In this context, a particularly overlooked mechano-sensing protein is spectrin, a resilient structural platform firstly described to maintain cell shape in erythrocytes and recently proposed to be involved in neuronal plasticity and maintenance of axon rigidity. Spectrin is ubiquitously expressed and the knock-out is detrimental. It is proposed to act as an elastic spring engaged in membrane-cytoskeleton connections, but molecular organisation and dynamic observations are unknown in most eukaryotic cell types. Particularly, is not understood how spectrin-based meshwork assemble-disassemble and react to mechanical perturbations, except from mostly static observations from erythrocytes and neurons. In this proposal, I plan to investigate spectrin dynamic during cell spreading, cell migration and its role in membrane mechanical adaptation. Using fibroblasts, a well characterized model system for membrane and cytoskeletal dynamic studies by Dr. Gauthier’s group, I aim to describe how spectrin dynamically contributes to cell shape changes, cell-substrate interaction and migration. With membrane-tension analysis by optical tweezers, time-resolved super-resolution microscopy, substrate micro-patterning techniques and various mechanical perturbations, I will unveil how spectrin reacts and contributes to mechanosensation and mechanotransduction. Overall, our results in fibroblast will elucidate the poorly understood contribution of Intermediate Filaments during mechanical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Social evolution in Ceratina bees: a comparative approach'.

assistant: **Innovation**

The origin of cooperation between individuals remains one of the main puzzles of evolutionary biology. Eusocial insects are one of most striking examples of extensive cooperation in which some individuals forego reproduction to help others. Yet research on eusocial insects concentrates mainly on species with large societies whereas species which exhibit facultative eusociality (some individuals live socially, other solitarily) are well suited for studying the origin of eusociality. I plan to study small carpenter bees (genus Ceratina), This is a globally distributed genus with approximately 200 described species which is an excellent model system for studying social evolution in a comparative approach because of their large interspecific diversity in social and parental strategies.My research has three main goals. Firstly, I shall construct a high-resolution molecular phylogeny of Ceratina based on next generation sequencing as a necessary framework for my comparative approach, namely the remaining two goals. Secondly, I shall evaluate the importance of traits underpinning sociality, parental care, nesting biology and mating by mapping them on phylogenetic trees. Thirdly, I will study covariance between relatedness and sociality across Ceratina species; they exhibit extensive variability in relatedness between offspring because females of some species mate with one partner, some with several and others are parthenogentic, allowing me to test the role of relatedness in social evolution. Biologists commonly study one or a few species in detail. However, I plan use comparative approach to compare strategies of multiple species and map life history traits onto phylogeny. My unique integrative approach will advance understanding of social evolution, parental care, and cooper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Genetic basis of host resistance and pathogen virulence in the Septoria-Wheat pathosystem' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Increasing agricultural sustainability has become more than ever a priority. In this sense, wheat plays a central role in EU agriculture as a major crop, and controlling yield losses due to diseases can be a serious bottleneck for agricultural sustainability. Septoria tritici blotch (STB) caused by Zymoseptoria tritici, is a globally occurring fungal disease that causes severe yield losses on wheat and is the source of a massive fungicide applications in the EU. Furthermore, Z. tritici populations evolve rapidly and their adaptation to the proposed control measures (monogenic resistance, fungicides) is a well-known phenomenon. Thus, breeding polygenic STB-resistant varieties is timely and represent the most durable and economic way to limit disease epidemics and reduce fungicide dependecy. However, this cannot be achieved without a thorough understanding of host-pathogen interactions and an extensive knowledge of (1) host resistances and their effectiveness in pathogen populations (2) pathogen virulence factors and mechanisms of overcoming host resistance. The research proposed here, “The Genetic basis of host resistance and pathogen virulence in the Septoria-Wheat pathosystem (SEPTOWHEAT)”, aims to address these gaps by using state-of-the-art genomics and genetic resources, to meet the challenges of STB resistance breeding and pathogen’s rapid adaptation. The project will be articulated in three integrated objectives: (1) genetic mapping of novel resistance loci/genes from diverse tetraploid wheats (2) identification of the corresponding pathogen (a)virulence genes and (3) development of diagnostic molecular assays to accelerate resistance introgression into elite pre-breeding material. SEPTOWHEAT will have numerous outcomes on durable STB resistance, reducing fungicid