RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Agriculture and Energy Efficiency', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Until now energy efficiency in agriculture has received little attention, except for energy use in greenhouses. Nevertheless, it is considerable, especially when indirect energy use is taken into account. AGREE has the objective of showing the potential of short term energy efficiency gains and the promise of the long term potential. Environmental effects of savings on direct and indirect energy use in agriculture are integrally considered, as energy use efficiency also implies reduction of greenhouse gas emissions. Because energy savings in agriculture depend highly on the agri-environment (climate), AGREE will bring together south-eastern, south-western, north-eastern and north-western agroproduction systems. Evidence from energy saving potential and corresponding environmental and economical effects on country level are brought to the transnational level to identify an agenda for transnational collaboration to increase the learning curve on energy use efficiency. AGREE will set up a participatory process for two reasons. 1. Stakeholders will be involved in the set-up of the agenda which will facilitate the implementation of the results. 2. AGREE needs the opinions and views of stakeholders to produce an agenda that reflects the needs of and opportunities by practice. To ensure implementation, a link has been created with a European network of researchers committed to adopt the issue. This network (ENGAGE) is closely associated with the European Society of Agricultural Engineers (EuAgEng). This link will facilitate the adoption process. To ensure that the results will create relevant and effective R&D programmes, AGREE has established a close link with the Collaborative Working Group on Agriculture and Energy. This group is embedded in SCAR and the KBBE-Net and is thu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'NUMERICAL SIMULATION OF DEFORMABLE SOLIDS IN TURBULENT FLOW' (NSDSTF).

assistant: **Concept**

The numerical simulation of deformable solids has many applications in fluid-solid interaction such as hydroelasticity and aeroelasticity. The greatest application is in medical engineering in which it will be possible to simulate the movement of tube like structures such as the oesophagus, intestines, bile duct, fallopian tube, uterus, ureter and blood vessels etc. However, the numerical simulation of the movement of individual blood cells in either a laminar or turbulent fluid flow is particularly difficult because it not only involves the correct modelling of the fluid flow but also the movement of the cells themselves which, in turn, requires the correct modelling of their dynamics, surface stresses and their surface deformations in response to these stresses. This project is aimed at investigating the deformation, movement and collision of deformable solids in laminar and turbulent flow. In order to do this it will be necessary to couple existing in-house discrete element and computational fluid dynamics codes. The boundaries of the solids will be allowed to deform under the pressures and stresses imposed on them by the surrounding fluid. Such a numerical scheme would also involve taking into account the possible collision of the cells and their ‘shielding’ and imbrication by other cells. The potential benefits of a code that could do this are enormous as it would be possible to investigate the exact cell movement mechanism, and lead to the design of better stents.   A further project objective is to carry out simulations of peristaltic pumping by wavelike contractions  which are fundamental biomechanical mechanisms  for fluid and material transport and are used in the oesophagus, intestine, oviduct and ureter.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Lower nitrogen losses in dairy farming through marker assisted breeding for nitrogen use efficiency and feeding value in ryegrass' under Fourth Framework.

assistant: **Concept**

The production of milk and meat in dairy farming in the EU - which is to a large extent based on the use of forage grass for feeding dairy cows is associated with high use of nitrogen inputs and with high imports of feed concentrates. This leads to high losses of nitrogen that pollute water (nitrate leaching) and air (ammonia volatilisation). This project aims at the development of selected genotypes and cultivars of forage grasses, in particular perennial ryegrass (Lolium perenne L.), That need lower nitrogen inputs to achieve the same milk and meat production. This will be achieved by the development and use of molecular masker selection for nitrogen use efficiency (NUE) and feeding value of grass for dairy cows. At present, grass breeding is not aimed directly at improving nitrogen use efficiency and only for a limited extent at improving feeding value. The reason is that the available evaluation techniques are too expensive or take too long for a fast genetic improvement. The development and use of marker aided selection for nitrogen use efficiency and feeding value of ryegrass would substantially speed up the process of genetic improvement, but requires the integration of different disciplines (plant physiology, animal nutrition and molecular biology).  This project aims to achieve this integration in order to develop fast and effective selection procedures (marker aided breeding) for nitrogen use efficiency and feeding value and to use the developed marker technology for the selection of ryegrass genotypes. This will be achieved by the combined effort of three research institutes, two grass breeding companies and a seed trading company (among which two smes). This development serves the long term goal of making it possible for dairy farmers to produce the same amo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Rupture of Aortic Aneurysms (AA), which kills more than 30 000 persons every year in Europe and the USA, is a complex phenomenon that occurs when the wall stress exceeds the local strength of the aorta due to degraded properties of the tissue. The state of the art in AA biomechanics and mechanobiology reveals that major scientific challenges still have to be addressed to permit patient-specific computational predictions of AA rupture and enable localized repair of the structure with targeted pharmacologic treatment. A first challenge relates to ensuring an objective prediction of localized mechanisms preceding rupture. A second challenge relates to modelling the patient-specific evolutions of material properties leading to the localized mechanisms preceding rupture. Addressing these challenges is the aim of the BIOLOCHANICS proposal. We will take into account internal length-scales controlling localization mechanisms preceding AA rupture by implementing an enriched, also named nonlocal, continuum damage theory in the computational models of AA biomechanics and mechanobiology. We will also develop very advanced experiments, based on full-field optical measurements, aimed at characterizing localization mechanisms occurring in aortic tissues and at identifying local distributions of material properties at different stages of AA progression. A first in vivo application will be performed on genetic and pharmacological models of mice and rat AA. Eventually, a retrospective clinical study involving more than 100 patients at the Saint-Etienne University hospital will permit calibrating estimations of AA rupture risk thanks to our novel approaches and infuse them into future clinical practice. Through the achievements of BIOLOCHANICS, nonlocal mechanics will be possibly extended
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Wireless Interactive Terrestrial Network Systems and Services'.

assistant: **Innovation**

WITNESS aims to upgrade existing prototype set top box units (from the iTTi project) for use with network interactive broadcast equipment to perform field trials of terrestrial interactivity. This work will lead to the deployment of improved and industrialised units for trials in real transmission networks. The performance of the complete system will then be extensively tested via technical field trials at two independents sites. WITNESS will examine EMC issues for the usage of the return channel and will improve the existing unit's diplexor architecture.Frequency planning and spectrum usage recommendations will be derived from planning tools for the deployment of in band UHF interactive terrestrial services.The emerging DVB-TRC standard will be evaluated and results of the WITNESS field trials and planning recommendations will be made available to the DVB projects.WITNESS will establish a users group drawn up from a wide variety of broadcasters and equipment manufacturers to help define and develop a consensus on interactive terrestrial technologies. WITNESS will participate in IST based summits and conferences and will produce papers to highlight and promote the technology.Objectives:The WITNESS Project Objectives may be summarised as:1. To develop, test, and validate the operation of a DTT Return Channel by deploying up-graded interactive wireless terminals in homes, and implementing challenging applications.2. To investigate the inter-working of 3rd generation mobile telephony and interactive terrestrial broadcasting networks.3. To develop spectrum planning tools, and frequency recommendations for complimentary DVB-UMTS services.4. To develop resource management techniques for DVB wireless interactive services.5. To drive standardisation in DVB and ETSI for a DTT in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Working careers and social advancement strategies of migrant women from Maghreb. The cases of Bologna and Naples, Italy.' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

The proposed research deals with the feminisation of migrant flows in southern Europe and, in particular, investigates the case of migrant women from Maghreb residing in Italy. The research analyses life and professional careers and social advancement strategies of migrant women living in two Italian cities, Naples and Bologna. In doing so, the research intends to provide a further understanding of the dynamics of women's social insertion into local labour markets and urban spaces in Europe.  The research takes into account four types of professional strategies as representative examples of the careers of the migrant women residing in Italy: domestic workers, business women, social workers and prostitutes. With reference to these professional positions, the research seeks to understand the extent to which women's constraints and opportunity structures mutually interact together within women's life trajectories, drawing on a multifaceted set of social networks, personal skills and individual strategies. The research shows the way in which, far from being subordinate and passive actors, women play a role as protagonists in migratory movements. In this perspective, the research seeks to demonstrate how the act of migrating has the potential for fostering relevant changes in women's lives and in those of the people surrounding them.   The proposed research is intended to enlarge my research interests and to re-connect my work to that undertaken by a broader community of scholars and practitioners alike. In particular, the research training will be devoted to developing a Euro-Mediterranean dimension of inquiry and debate over issues of gender and international migration. In doing so, the research fellowship will provide a unique opportunity to enhance my research profile as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Molecular mechanisms orchestrating  the lifecycle of human tRNAs'.

assistant: **Concept**

By delivering amino acids to translating ribosomes, transfer RNAs (tRNAs) are central to protein synthesis. These small (~76 nucleotide-long) molecules have very similar three-dimensional structures, which must withstand substantial conformational changes throughout the tRNA lifecycle. To meet these demands, tRNAs are decorated by diverse chemical modifications at multiple nucleotides by highly conserved enzymes. Defects in the genes encoding these enzymes are linked to neurodevelopmental disorders. Yet, our understanding of how chemical modifications promote the biogenesis, function, and stability of individual tRNAs is limited due to technical challenges in quantifying tRNAs and the impact of their modifications on mRNA translation in human cells. We recently developed workflows to meet these challenges, enabling dissection of the tRNA lifecycle in physiologically relevant human induced pluripotent stem cell (hiPSC)-based models. Building on these advances, this proposal aims to uncover the key mechanisms orchestrating the birth, life, and destruction of human tRNAs by answering three questions: which chemical modification steps are essential for the function of individual tRNAs; how do cells sense and respond to defects in translation due to tRNA dysfunction, and how do cells dispose of excess or aberrant tRNAs. To achieve this, we will combine functional genomics with quantitative high-throughput approaches and biochemical assays in hiPSC-derived cells and brain organoid models. This project will significantly advance our understanding of the fundamental mechanisms governing the lifecycle of tRNAs to ensure accurate and efficient protein synthesis in pluripotent and differentiated human cells, and identify molecular triggers for neurodevelopmental disorders linked t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Israel Researchers Night 2006' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Scientific research and its achievements are no longer merely an abstract intellectual pursuit... but a central factor... in the life of every civilized people... (David Ben-Gurion, 1962) The Israel researchers night will take place on the 19th of September 2006 in seven locations across Israel, it will involve 150 researchers and aim to reach 15,000 members of the public.The main aim of this project is to put research and researchers into the spotlight of the general public to enhance, strengthen and pre sent, in an exciting fashion, the rich cultural heritage of science in Israel and the European Union; enhancing science literacy among Israelis of all ages; and attracting and encouraging youngsters to pursue studies and later on, opt for a career in science and technology; render science and technology accessible and enjoyable to Israelis of all backgrounds.Reinforce interactive encounters not only with science educators, exhibits and hands-on experimentation, but also provide an opportunity for lively, informal interchange, between scientists/researchers and the general public of all ages.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Histopathologic and Mechanistic Assessment of Angiogenesis Inhibitor Related Toxicities: A Cross-Sectoral, Multi-disciplinary Approach' (ANGIOTOX), addressing dissemination and exploitation.

assistant: **Impact**

Inhibition of angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a well established therapeutic strategy against cancer. Inhibitors of angiogenesis have been developed to block tumour growth and metastasis, and a number of these inhibitors are now clinically approved. However, contrary to initial expectations, angiogenesis inhibitors can cause a range of toxicities in patients. AngioTox is a cross-sectoral collaboration in the field of biomedicine, responding to a pressing need to understand mechanisms of toxicity associated with angiogenesis inhibitor treatment. AngioTox is comprised of academic groups, SMEs, a global pharmaceutical leader in angiogenesis inhibitor development, and a large company concerned with monitoring drug modulation of cellular pathways. The goal of this consortium is to facilitate comprehensive histopathologic and mechanistic assessment of angiogenesis inhibitor related toxicities following treatment with the two main class of angiogenesis inhibitor; monoclonal antibodies and tyrosine kinase inhibitors. A combined in vivo modelling and digital histopathology approach will be engaged to comprehensively describe a new AngioTox Safety Panel of toxicologic markers. We will develop automated image analysis algorithms to enable quantification of morphological markers of angiogenesis inhibitor toxicity, and will undertake molecular profiling and ex-vivo studies to gain insight into mechanistic pathways. Specialized secondments proposed within AngioTox will facilitate several opportunities for high-end training of researchers across both industry and academia. Findings from the AngioTox programme may be directly utilised by academic, clinical and industry-based investigators to facilitate improved screening of angiogenesi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Modelling Inter-Scale Energetics in  GastroIntestinal ElectroMechanics', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The MiGEM proposal targets one of the remaining grand challenges in biomechanics: the development of a comprehensive, inter-scale, thermodynamically and energetically coherent multiphysics model of gastrointestinal (GI) motility. Despite the importance of gastrointestinal disorders as a primary global health problem, electromechanical modelling of gastrointestinal motility still presents significant theoretical and experimental limitations compared to more advanced fields such as cardiovascular bioengineering. Technical difficulties exist due to the intrinsic multiscale nature of gastrointestinal tissues, the coupling of multiple cell types and roles, and the combination of electrical and mechanical phenomena involving different energetic mechanisms. MiGEM has the potential to unlock new frontiers in GI research, addressing several state-of-the-art problems in gastrointestinal motility and opening unprecedented opportunities in novel subject-specific therapies. By adopting a rigorous theoretical-experimental scientific approach, MiGEM will advance state-of-the-art gastrointestinal theoretical modelling and experimental measurements, unveiling fundamental energetic mechanisms that govern stomach and intestine motility in health and disease. MiGEM will enable the first calorimetric measurement of tissue sample from the GI tract and create a new path in biomechanical modelling by assimilating innovative data into multiscale thermodynamic models. The project will create a new network of scientists with complementary experimental and modelling skills, fostering cross-fertilization, providing senior-to-junior methodological transfer, and supporting gender balance. The scientific experience of the PI, the formal membership to the project of the ABI, University of Auckland, and