RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'EUROPEAN PERFORMING SCIENCE NIGHT'.

assistant: **Objectives**

The theatre company La Fura dels Baus (established in 1979) started a creative foundation Fundacion Epica to transfer -as informal training- the lessons learnt during the many decades of organising successful and engaging performances. Epica developed and tested creative interaction methodology and their physical venue in Badalona (Spain) will host the proposed  European Performing Science Night.  The European Performing Science Night (EPSN) puts forth a science- expanding methodology based on the combination of scientific excellence and performing arts as generators of faked realities and engagement. Through co-designed preparatory work leading to a Night of Performing Science, the event will bring researchers closer to the general public (and vice versa). It will increase awareness of what is research, its function in a democratic society, and its benefits for a diverse Europe. EPSN proposes a wide range of innovation activities, with a view to supporting the public recognition of researchers, their work, and the value it brings to society. EPSN will in itself be a scientific event, where research groups will deploy experiments with a broad spectrum of civil society and science both online and face to face. Audiences will perform, in artistic terms, as subjects themselves in experiments, taking part in both the tests during the event and expected results in the performaforum.EPSN will test and demonstrate new methodological approaches to bring researchers closer to the public through an innovative language based on the performing arts and new language tools for researchers, that is, 1 training to equip researchers with new tools to deal with scientific communication; 2 the realization of artistic co-creation based on the work of researchers to show the diversity of sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Capitalising Notch Biomarkers in the Drug Development Market' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

CapNotch is the translation from discovery of multimodal cancer biomarkers of the Notch pathway to a strong market proposition. Biomarker products for validating specificity, efficacy and toxicity of preclinical compounds that target this pathway are highly wanted by academia and industry and could fuel progress in this area. One step further lays the opportunity to exploit such biomarkers for patient stratification and treatment monitoring, as well for advancing clinical trials as for supporting clinical decision making. The outcome of CapNotch should guide the selection of the most feasible proposition.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Solid Basis for Symmetric Cryptography' (SoBaSyC).

assistant: **Concept**

Symmetric cryptography, essential for enabling secure communications, has benefited from an explosion of new results in the last two decades, in big part due to several standardization efforts: many public competitions have been launched since 1997, where the community proposes cryptographic constructions and simultaneously evaluates their security and performance. The security of symmetric cryptography is based on cryptanalysis: we only gain confidence in a symmetric cryptographic function through extensive and continuous scrutiny. However, the current context has not allowed the community to digest all the new findings, as can be seen from several recurrent issues. The two main ones are: 1) primitives proposed at top-tier venues often get broken by slight modifications of already known techniques;2) published cryptanalysis at top conferences sometimes include mistakes or are suboptimal. They are also often re-invented and re-named.The main challenge of SoBaSyC is to establish solid bases for symmetric cryptography. Using cryptanalysis as the starting point, my aim is to unify the knowledge obtained through the years on the different families of attacks, to transform it with an algorithmic approach and to endow it with optimizations. The final result will be a toolbox congregating all our newly proposed optimized algorithms, that will provide the best known attacks on a given construction, through an easy application. Next, I plan to derive from this algorithmic approach some theoretical bounds, as well as some properties that I will include in the security proofs of symmetric constructions, providing more meaningful and realistic security arguments.This would allow, for the first time, to ensure that any newly proposed primitive or construction is already resistant to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Using deep-sea corals to test the role of the deep Southern Ocean in ocean circulation and the regulation of atmospheric carbon dioxide', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The convective circulation of the world's ocean exerts important controls on two key aspects of the climate system: the transport of heat around the Earth and the degree to which the oceans sequester greenhouse carbon dioxide away from the atmosphere. Models of the past circulation predict variations in its strength that have been implicated in climate change. Marine sediments record changes in ocean chemistry that can be used to test these models. This approach has been pursued with great success in the North Atlantic. The Southern Ocean, on the other hand, is much less studied because of a lack of suitable sediments that record ocean chemistry. And yet, the Southern Ocean and its circulation system may be the key to both heat transport and isolation of a deep ocean carbon reservoir.   This proposal seeks to provide key constraints on some of these issues using a unique set of deep-sea coral samples from the Pacific sector (70°S) of the Southern Ocean provided by the British Antarctic Survey and the Alfred Wegener Institute. Specifically we aim to use the radiocarbon ages of the corals, coupled with their calendar ages, to investigate the degree of isolation of the deep Southern Ocean carbon reservoir from the atmosphere, and therefore the extent to which this isolation might explain low atmospheric CO2 during recent glacial periods in Earth history. We also seek to use them to provide basic chemical information on the deep Southern Ocean, information that is key to many studies that use the chemistry of the past North Atlantic Ocean to try to understand ocean circulation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Direct Manufacturing of stator vanes through electron beam melting', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

New aeronautical engine designs strive the manufacturers to use new processes which permit to add specific features such as stiffeners, often leading to weight or lead time saving. Electron Beam Melting (EBM) process is potential candidate but is not yet fully understood and controlled because of its lack of maturity. Case studies show that the waste of raw material is reduced by up to 40% when using Additive Manufacturing (AM) technologies - such as EBM - instead of subtractive (machining) technologies. It is due to the capacity of AM technologies to build parts directly from 3D models.For the aerospace parts, the reduction of the raw material consumption is essential, but mechanical properties must be guaranteed. One must guarantee that the recycled powder is comparable in all above mentioned aspects to fresh powder. Also, the differences that may appear between fresh and recycled powder must not interfere in mechanical performance of functional parts built of recycled powder. So far, no specific criteria exist in terms powder recyclability such as the number of manufacturing. Also, no study of recyclability has been published.AEROBEAM is aimed at investigating the mechanical properties of aeronautical Ti6Al4V stator vanes elaborated by EBM. During this project, optimization of build parameters, characterization of processed material, characterization of recycled powder and characterization of material processed out of recycled powder will be performed. The results aim at ensuring that the stator vanes built in WP5 are completely reliable regarding aeronautical requirements and can be equally used no matter if vanes are built from fresh or recycled powder as long as the powder is below its maximum level of recyclability.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Towards high-affinity ligands for orphan receptors GPR3, GPR6 & GPR12' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The family of G protein-coupled receptors (GPCRs) comprises more than 800 human cell surface receptors that perceive and transmit extracellular stimuli into the cell interior. Due to their involvement in numerous biochemical processes, GPCRs represent prime targets for the treatment of various diseases and are modulated by more than 30% of approved drugs today. However, a large proportion of the druggable GPCRome remains pharmacologically untapped, including the so-called ‘orphan’ GPCRs (oGPCRs) - receptors for which the endogenous ligands remain unknown.GPR3, 6 and 12 constitute a cluster of orphan GPCRs that is involved in numerous (patho-)physiological processes including neurodegenerative disorders such as Parkinson’s and Alzheimer’s dementia. GPR3 and GPR12 further mediate meiotic arrest in oocytes and suppress the development of metabolic diseases. Other physiological processes and diseases associated with GPR3/6/12 are neuropathic pain perception, addiction and different forms of cancer. Although these receptors represent promising pharmacological targets and researchers have been trying to discover molecules targeting these receptors for more than two decades, only a limited set of five ligands is currently available. Modern GPR3/6/12-targeted drug discovery is still hampered by the lack of verified endogenous ligands, our poor understanding of their structural organization and signalling cascades promoted by these receptors, and a limited panel of assays revealing GPR3/6/12 activity in living cells.Here, I propose to implement an interdisciplinary research approach combining computational methodologies with advanced biosensor technology in order to discover advanced ligands for these attractive drug targets. These novel compounds will aid in developing advanced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Demonstration of the feasibility of recombinant virus-like particles derived from baculovirus for vaccine production in industrial conditions' to be submitted under Fourth Framework.

assistant: **Abstract**

The principal objective of this proposal is to demonstrate the applicability of the new technology based on the expression of recombinant viral empty capsids in insect cells using the baculovirus expression system (BEVS) for the production of vaccines on an industrial scale. The production of empty particles that mimic perfectly the original viral structures is becoming more and more popular in the literature. Most, if not all, of these empty particles have shown optimal immunological properties that make them suitable candidates for vaccine production. Unfortunately, the applicability of this technology has been hampered by several factors, including: lack of knowledge of the BEVS culture and recovery conditions for medium and large scale in insect cells, the cost and organization of the experiments required for showing the efficacy and potency of the antigens in field conditions, and, finally, the burden and complexity of the regulatory affairs to get the registration of a recombinant vaccine. In this proposal we address the first two problems using the production of porcine parvovirus empty particles as a model. PPV is responsible for a major reproductive disease in pigs, which is usually controlled by vaccination. This product has been successfully expressed in the baculovirus system but need application of medium to large scale culture technology to demonstrate that they have real potential as cost-effective recombinant vaccines. It is anticipated that knowledge derived from the study of this target will also be useful for the production of other proteins and vaccines. The problem will be studied through several work packages. The first package will address the issue of optimising expression of the recombinant particles, to maximize protein production. Optimal grow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EURopeAn MEDical application and Radiation prOteCtion Concept: strategic research agenda aNd ROadmap interLinking to heaLth and digitisation aspects' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The 3-year EURAMED rocc-n-roll project aims to propose an integrated and coordinated European approach to research and innovation in medical applications of ionising radiation and related radiation protection based on stakeholder consensus and existing activities in the field (incl. existing SRAs of radiation protection platforms, EC health and digitisation programmes, EURATOM-funded projects, SAMIRA initiative). To achieve this, research and radiation protection needs in the clinical disciplines using ionising radiation will be analysed with the aim to generate the largest benefit for the European population in an equal, safe, high-quality way throughout Europe, by fostering clinical translation, while also strengthening economic growth and industrial competitiveness, supported by research and innovation in the field. Representation of relevant radiation protection disciplines like radiation biology, dosimetry for medical applications, ethics  as well as clinical expertise in the fields of radiology, nuclear medicine, radiation therapy, oncology, cardiovascular diseases, neurology, paediatrics complemented by regulatory and health policy, AI and industry experts in the consortium will ensure a fully integrative approach and allow a broader framework of quality and safety in healthcare. Based on wide stakeholder input and consultation on above aspects, EURAMED rock-n-roll will produce an SRA for medical applications of ionising radiation and related radiation protection and a corresponding roadmap, as well as an interlink document, integrating the views and identifying synergies from the areas of radiation protection, health research and digitisation, with impactful guidance to the EC and stakeholders on future research including the potential needs for centres of excel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Thermal and electrical Mock-ups for Thermal Management of a Ground Integration Test Rig' (TEMGIR).

assistant: **Innovation**

The TEMGIR project is for the design and development of Thermal and Electrical Mock-ups for the validation of the thermal behaviour in the electrical air systems architecture at aircraft level.TEMGIR will provide a thermal model of an aircraft with both electrical and thermal behaviour, which will be able to develop any relevant condition and scenarios within the different flight phases. The TEMGIR has a thermal response based on its power supply which will be governed and monitored by the Control and Monitoring SW System. TEMGIR SW will let loading equipment profile and a flight scenario in order to simulate behaviours during flight phase with special situations and location in aircraft.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Joint research on various types of radiation dosimeters' (RADDOS).

assistant: **Innovation**

The project includes research on various types of radiation dosimeters for application in space, nuclear facilities, high energy particle physics research, clinical environments, and personal dosimetry. Complementary expertise and infrastructures of the project partners are employed through a coherent set of activities aimed at increasing partners' research output, exchange of experience, and networking with renown European laboratories. Particular emphasis is put on development of Western Balkan partner's S&T potential to achieve its better inclusion into European research community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Interplay between genetic determinants of glycaemia, type 2 diabetes and cardiovascular disease in interaction with dietary and lifestyle factors' (INTERPLAY) under Horizon 2020.

assistant: **Objectives**

Genome-wide association studies (GWAS) for complex traits, including glycaemia, type 2 diabetes (T2D) and coronary heart disease (CHD) have been successful in identifying genetic variants associated with those phenotypes. However, they explained only a small proportion of the estimated heritability. Possible reasons include the interplay between genetics and lifestyle determinants, small-effect variants, structural variations and the difficult to characterize non-coding functional variants that interact with other genetic regions. This proposal, in a new era of precision medicine, englobes the systematic study of the interplay between genetic variants associated with glycaemia, T2D, CHD and dietary and lifestyle factors. We propose to conduct a comprehensive analysis of gene and gene-lifestyle interaction, including the existing international GWAS consortia of CARDIoGRAM, DIAGRAM, MAGIC, the U.S. based DPP clinical trial, and the European-wide networks of EPIC-InterAct and PREDIMED. We will test hypothesis about: 1) whether genetically driven hyperglycaemia increases risk of CHD, 2) the association between genetic determinants of CHD and intermediate metabolic phenotypes, and 3) whether dietary components and lifestyle changes influence these associations. Finally, we will extend and replicate these previous results in two independent populations, and to deploy a new method to identify implicated biological pathways. Information that will emerge from that project will provide valuable insights into missing heritability for T2D and CHD. Specifically we expect to uncover genetic determinants for faster CHD progression in T2D, identifying vulnerable individuals who are more likely to experience a differential response to current prevention strategies and to validate potent