RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ceramic Heat exchangers with enhanced materials properties' (CEREXPRO), addressing dissemination and exploitation.

assistant: **Impact**

Heat recovery at a high temperature level is essential in industrial thermal processing. The use of ceramic materials yields higher temperatures and subsequently a higher efficiency.  The present project aims to develop a new generation of ceramic heat exchangers for high temperature heat recovery with the target of significantly reducing the size and weight as well as also the price of such components by simplifying the manufacturing process and allowing a higher flexibility in the heat exchanger geometry. The use of precursors/template materials taken from the textile industries and a subsequent ceramic conversion is proposed as the main technological path for reaching the above objectives. Although this principal option is not new, there are no development efforts known, to utilize such a technological approach for industrial high temperature heat exchangers. The proposed route will lead to an increase in freedom of the geometric design at low costs for shaping. The development/refinement of the conversion process for such materials into a thermal-shock resistant gas-tight ceramic (e.g. silicon infiltrated silicon carbide) and the multi-objective optimization in terms of size, geometry, material and production costs is the major challenge of the proposed project.  A complete ceramic heat exchanger component shaped by textile technologies is targeted. The combination/junction of existing robust ceramic components already applied in industrial furnaces, like silicon infiltrated SiC tubes, with compatible ceramic heat enhancement elements, built through the textile technology based manufacturing process, allows a robust construction in terms of application safety as an intermediate technology development step. At the same time a significant size reduction or increase of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cancer metabolic profiling through ion mobility and mass spectrometric-based methods' (CMPtIMSMS) under Seventh Framework.

assistant: **Objectives**

Cancer is a leading cause of death and there is little doubt regarding the importance of its early detection, in order to reduce both mortality and healthcare costs. In this regard, metabolomics is becoming a popular approach on the prowl for early diagnosis of cancer.Because biomarker discovery requires the analysis of numerous samples of high complexity, the development of high-throughput analytical platforms is of great interest. One such technology is ion mobility-mass spectrometry (IMS-MS). However, interfacing traditional drift-tube IMS with commercial MS requires substantial modifications of the latter, precluding its rapid expansion in metabolomic studies. Alternatively, differential mobility analyzers (DMA) are more easily combinable with commercial MS. We propose here to use a DMA-MS system to interrogate the metabolic phenotype of lung cancer tissue extracts.Complementarily to this plan, we intend to execute a second research strategy. Exhaled breath provides a continuous window to the biochemical activity within a person, and so holds promise as a diagnostic tool. However, in spite of the important milestones achieved following different approaches during the recent years, several issues remain to be solved before breath analysis may become a routine cancer screening method. Recently we have shown that with simple modifications, commercial mass spectrometers can sense in real time novel metabolites (e.g. glucose) in breath than previously detected.  Here, we propose to employ this technology to compare the breath metabolic profiles of control subjects and cancer patients; and cancer patients before and after tumor removal.The aims are: (i) to advance in the development of alternative analytical platforms in metabolomics, (ii) to increase the knowledge of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrated photonics-based structured illumination for sequencing' (INPHOSIS).

assistant: **Concept**

High-throughput next-generation sequencing has revolutionized healthcare. Nevertheless, widespread adoption remains hindered by a trade-off between clinically relevant turnaround times and cost-effectiveness. This trade-off arises from the limitations of sequencing-by-synthesis (SBS) chemistry and traditional optical readout architectures. To address this, integrated parallel readout on a CMOS imager is the preferred technology – as opposed to free space microscope scanners. However, size and number of pixels pose a critical limit on throughput. A novel technology developed in the IROCSIM ERC StG presents a unique solution by enabling sub-pixel resolution readout, leading to orders of magnitude increase in read density per pixel—unlocking the 1 billion-plus reads range. It monolithically integrates an imager with filters and photonic-integrated-circuit-generated, IP protected, structured illumination patterns. This project aims to demonstrate the commercial and technical potential of this technology for sequencing applications. This innovation could be a fundamental breakthrough in a longstanding bottleneck in sequencing products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Verification of Concurrent Data Structures', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Increasing performance demands, application complexity and explicit multi-core parallelism makes concurrency omnipresent in software applications. However, due to the complex interferences between threads in an application, concurrent software is also notoriously hard to get correct. Instead of spending large amounts of money to fix incorrect software, formal techniques are needed to reason about the behaviour of concurrent programs.In earlier work, we developed a variant of permission-based separation logic that is particularly suited to reason about multithreaded Java programs with dynamic thread creation and termination, and reentrant locks. The VerCors project will extend expressiveness of the logic, to specify and verify concurrent data structures. The verification logic will be parameterised over the locking policy, so that a high-level specification of the behaviour of a data structure can be reused for different implementations. Thus the implementation of a concurrent data structure can be changed, without affecting correctness of the applications using it.The logic will also be parameterised with concurrency and synchronisation primitives, so that a logic for a different programming language can be defined as an instance of the general logic. It will also be adapted to reason about programs with benign data races, i.e., data races where the same value is written simultaneously by different threads. Also techniques to generate part of the specifications automatically will be developed. Finally, the logic will be adapted to a distributed setting, where data consistency between the different sites has to be maintained.All results will be integrated in a tool set that generates and proves proof obligations automatically. It will be validated on realistic case studi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Research Knowledge Documentation, Analysis and Exploration in Empirical and Descriptive Sciences' under Horizon 2020.

assistant: **Concept**

Descriptive and empirical sciences, such as History, Archaeology, Biodiversity, and Cultural Heritage, are the sciences that collect, observe and describe phenomena in order to explain them and draw interpretative conclusions about their behaviour and their relationships under given circumstances. Researchers in these sciences usually encounter problems related to the integration of data coming from different sources, the epistemological adaptation and refinement of their research under specific circumstances, the usability of their data analysis methods and tools, and the transparency and reliability of their research processes and results. The ReKnow project aims to support researchers in descriptive and empirical sciences to better handle these problems by providing models, algorithms and tools that allow for better documentation, analysis and exploration of research processes and data. This will be achieved by combining i) the expertise of the host institution in cultural informatics, its strong background in conceptual modeling and argumentation theory, and its long-standing collaboration with a large number of organisations in descriptive and empirical sciences, ii) a set of training activities that will provide the principal researcher with the required disciplinary and interdisciplinary background to achieve the project objectives and which complement his current expertise in semantic web technologies, exploratory search, and data mining, and iii) the close collaboration with two History projects and a research institute dedicated to the study of the history of science, that provide requirements, use cases and data as well as the opportunity to directly apply the ReKnow results in real scenarios.


**Keywords:** cultural informatics,  conceptual modeling,  argum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Climate and conflict in the Eastern Pacific: exploring a possible catastrophic coastal El Niño event and its impact on ancient Peruvian societies (320-200 BCE) through an interdisciplinary approach.'.

assistant: **Innovation**

Coastal El Niño (CEN) events have affected the northern half of Peru's coast for millennia bringing very warm climate conditions that lead to heavy rainfall and floods. In the central Peruvian desert of Casma, the presence of numerous fortified settlements dating from around 320-200 BCE suggests that their construction occurred during a period of warfare and regional instability. However, the reasons behind this instability remain unclear. The larger of these fortresses, Chankillo, may hold the key to understand when and why these structures were built.Well-preserved wooden lintels in Chankillo’s structures provide an opportunity to study the environmental past. A preliminary tree-ring width study revealed an anomalous wide ring in timbers from the lintels just before Chankillo’s construction, which could be the result of a CEN-induced catastrophic episode of heavy rainfall. This extreme CEN may have sparked instability and warfare, shaping central Peruvian history around 2,300 years ago.PACHACUTI aims to determine whether a catastrophic CEN event took place around 320-200 BCE, before Chankillo’s construction, by combining dendroarchaeology, annually-resolved stable oxygen isotope (18O) analysis and radiocarbon wiggle-matching. This ground-breaking interdisciplinary approach will use samples from Chankillo’s architectural timbers to develop an 18O chronology capturing hydroclimate variability over the 120 years before Chankillo’s construction. This novel record will encapsulate the frequency, magnitude and impacts of past CEN events during this period, offering insights into the climatic context surrounding Chankillo’s origins. Furthermore, it will also serve to date other archaeological sites in the region. If proven, this discovery will reveal the oldest known CEN eve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Targeting a science-based approach to REd coral reSTORation in a climate change scEnario' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

RESTORE deals with the need to restore Corallium rubrum, the Mediterranean red coral, a species of great ecological and commercial value that is of priority for conservation under European legislations because in sharp decline due to overharvesting and climate change effects. RESTORE will pave the path to innovative nature-based restoration approaches harnessing ecological processes thereby underpinning red coral recruitment success to foster its long-term and large-scale recovery and support its resilience to climate changes, overcoming the limitations of the existing restoration methods (e.g., coral transplantation). RESTORE will provide advanced knowledge on positive species interactions - i.e. between coral larvae, coralline algae and their associated microbiome, which are recognized as potential enable factors to enhance coral larvae recruitment. Biofilms of selected isolated bacteria strains will then be produced and tested to be used in coral restoration techniques in both control and natural conditions. The effects of global warming on these positive species interactions, and as a consequence on coral recruitment success, will be experimentally assessed to provide threshold values to be integrated in mathematical modelling approaches that will be applied to predict climate refugee areas for red coral recruits and to spatially guide future restoration projects in the view of diverse climate change scenarios. A marked multidisciplinarity, i.e. in-field and experimental ecology, DNA-based techniques and bioinformatics, mathematical modelling, will boost RESTORE effectiveness through the application of cutting-edge techniques. RESTORE will deliver relevant outcomes to support restoration actions under the EU Biodiversity Strategy and the Green Deal, and will provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Computational Investigations of Allostery between Proteins and Nucleic Acids in CRISPR-Cas9' in the context of a Horizon 2020 call.

assistant: **Objectives**

Allostery is a fundamental property of proteins, which regulates biochemical information transfer between spatially distant sites. Many emerging allosteric targets are large protein/nucleic acid complexes responsible for genome editing and regulation, whose underlying signaling remains poorly understood. Here, we focus on CRISPR-Cas9, a large nucleoprotein complex widely employed as a genome editing tool with enormous promises for medicine and biotechnology. In this system, an intricate allosteric signaling is suggested to span the multi-domain Cas9 protein and its associated nucleic acids, controlling the system’s function and specificity. However, in spite of extensive experimental characterization, the molecular basis for this allosteric response are largely unknown, hampering also efficient engineering for improving its genome editing capability. Allosteric-CRISPR will investigate the allosteric regulation in CRISPR-Cas9 by introducing a novel synergistic approach. This will implement the combination of state-of-the-art theoretical methods, including enhanced and multiscale approaches based on classical and ab-initio methods, with network models derived from graph theory and novel centrality analyses that are emerging as powerful to investigate allostery. This will create an innovative protocol that will enable determining the allosteric network of communication over multiple timescales, as well as the relation between allostery and catalysis, which remains unaddressed through classical approaches. This novel way to describe allostery can impact future studies of large nucleoprotein complexes, including newly discovered CRISPR systems, which are governed by similar allosteric rules and hold tremendous potential for genome editing. Finally, by delivering fundamental
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Impact of climate on mountain denudation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Mountain ranges evolve in response to tectonic uplift, erosion and climatic change, but decoupling the feedbacks between these processes remains one of the most active debates in Earth Science. Resolving this debate is fundamental for successful projection of Earth’s surface response under a changing climate. The Impact of ClimatE on mountain Denudation remains highly contested because no technique is available to resolve changes in erosion rates over the timescale of glacial-interglacial cycles i.e. 10^3-6 years, a key time range for quantifying the role that silicate weathering and denudation plays in modulating global climatic change. ICED will resolve this debate through establishing time-series of rock erosion over 10^3-6 years, allowing erosion rate changes to be related to specific climatic changes, and specific processes, for the first time. These data will show whether tectonics or climatic feedbacks on surface processes are dominant in determining rates of surface denudation, providing insights into the influence of the lithosphere on global climatic change throughout the Quaternary period (ice age).The objective of ICED will be achieved through the development and application of recently established thermochronometers based on the luminescence and electron spin resonance of quartz and feldspar minerals. Thermochronometers measure the rate of rock cooling, from which rates of rock exhumation and thus erosion rates can be calculated. Unlike existing methods, the new techniques developed within ICED are capable of resolving changes in erosion over timescales of between 10^3-6 years. Combining these new methods with cosmogenic nuclide data, using numerical models developed within ICED, will allow the generation of high-resolution time-series of erosion. The strat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biomarker Applications for Nanotechnology and Imaging in Diabetes' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

UroSense is a focussed research programme to generate new concepts from knowledge creation to knowledge transfer between innovative academic and dedicated industry partners utilising a systematic intersectoral secondment programme.  The programme brings leading edge academic European LifeScience capacities of Diabetes research at Dublin City University, Ireland, together with the high-profile protein research center of University of Luxembourg to establish innovative biomarker utilisation. The nano-biotechnologies developed with established life science applications of Tethis S.p.A of Milano, Italy will be the SME partner to translate findings to microfluidic applications while GE Medical System of Sweden will integrate results to the recently established, robust molecular imaging technologies leading to novel diagnostics for the benefit of the diabetes patient. The Chinese partner is a leading biotech company in Guangzhou who will provide not only validation of results but also to develop access to the fastest growing global healthcare market benefiting both academic and industrial partners.  All European partners are unequivocally in the leading edge in their own sectors sharing the vision of true impacts achieved with a new collaborative working model including efficient knowledge transfer and a shared clear scientific focus. Our consortium is particularly well balanced, focussed and well resourced to cover the value chain from discovery research to applications utilising novel intersectoral collaborations to expedite the utilisation process.