RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Nanoscale dynamics in the extracellular space of the brain in vivo' in the context of a Horizon 2020 call.

assistant: **Objectives**

Aggregates of proteins such as amyloid-beta and alpha-synuclein circulate the extracellular space of the brain (ECS) and are thought to be key players in the development of neurodegenerative diseases. The clearance of these aggregates (among other toxic metabolites) is a fundamental physiological feature of the brain which is poorly understood due to the lack of techniques to study the nanoscale organisation of the ECS. Exciting advances in this field have recently shown that clearance is enhanced during sleep due to a major volume change in the ECS, facilitating the flow of the interstitial fluid. However, this process has only been characterised at a low spatial resolution while the physiological changes occur at the nanoscale. The recently proposed “glymphatic” pathway still remains controversial, as there are no techniques capable of distinguishing between diffusion and bulk flow in the ECS of living animals. Understanding these processes at a higher spatial resolution requires the development of single-molecule imaging techniques that can study the brain in living animals. Taking advantage of the strategies I have recently developed to target single-molecules in the brain in vivo with nanoparticles, we will do “nanoscopy” in living animals. Our proposal will test the glymphatic pathway at the spatial scale in which events happen, and explore how sleep and wake cycles alter the ECS and the diffusion of receptors in neuronal plasma membrane. Overall, BrainNanoFlow aims to understand how nanoscale changes in the ECS facilitate clearance of protein aggregates. We will also provide new insights to the pathological consequences of impaired clearance, focusing on the interactions between these aggregates and their putative receptors. Being able to perform single-molecule
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Shifts in ecosystems state in Mediterranean landscapes: when, where and how? The interacting effects of multiple disturbances under climate change' (RESCRI) targeting Seventh Framework.

assistant: **Abstract**

The consequences of altered disturbance regimes in the context of global change will be profound. Despite the interacting effects of multiple disturbances and of altered disturbance regimes are extremely difficult to predict, it is becoming increasingly clear that many ecosystems have critical thresholds at which the system shifts abruptly from one state to another. Such behavior has profound implications for ecosystem management and conservation and for the sustained production of ecosystem services.Mediterranean-type ecosystems (MTEs) may be among the most impacted systems by global climate change drivers as a result of increased recurrence in climatically-induced drought events and its interaction with altered fire regimes. Although MTEs vegetation is highly adapted to fire and drought, alteration of such disturbances can promote ecosystems shifts due to crossing of ecosystem thresholds and/or altered system feedbacks. However, little work has been done in MTEs in this respect and the understanding of mechanisms underlying their resilience and the combined and synergistic effects of multiple disturbances need to be better understood.This proposal aims to fill an important scientific knowledge gap by evaluating ecological mechanisms governing system behavior and the occurrence of alternate states in MTEs. The main objectives are i) to increase our capability in predicting changes in ecosystem properties and dynamics and ii) to assess early-warning signals that may indicate proximity to drastic system changes, to aid in the definition of adaptive management policies to successfully address environmental threats. A novel dynamic modeling framework incorporating the stochastic effects of multiple disturbances (fire and drought) and their interaction with vegetation chara
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Simple minds – competition of parallel neural filters in behaviour selection of Drosophila'.

assistant: **Innovation**

How we and other animals make up our minds is an everlasting question that has occupied philosophers and scientists for centuries. Sensory-evoked activity patterns, memory engrams and internally generated brain activity conveying the animals internal state are meant to integrate to promote an appropriate behaviour. Still, direct evidence for how integration works on the network, the neurophysiological and the molecular level remains limited. Exemplifying internal needs with tiredness and hunger, and focusing on the numerically simple brain of Drosophila, we here test a parallel filter hypothesis to explain how sensory and internal states are integrated across the relevant centres of the fly brain. We posit that parallel neural filters will have changed permeability for sensory stimuli and to compete: e.g., if hungry, neural networks promoting food approach behaviour will change their permeability for sensory cues relative to those promoting sleep. Our approach will visualise neural activity, while recording online fly behaviour related to hunger, sleep and experience on a treadmill. It will tackle the physiological basis shaping filters, including oscillatory cell and network activities as well as synaptic gating, while recording whole brain activity. We capitalise on our expertise in functional imaging and previous discoveries of hunger and sleep gates as well as their synaptic and network substrates. We will investigate and interfere with key molecular factors underlying filtering to directly challenge network integration and behavioural outcome. Finally, we will remote control competing parallel filters, to test whether sensory permeability can switch the animals state between an ego- and an allocentric-like world view and whether depression-like states related to le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Developing New Technologies to meet 21st Century Demands in Animal Forensics' in the context of a Seventh Framework call.

assistant: **Objectives**

DeTECH21 will provide through SME led and directed research new forensic testing services based on metabolomic profiling which will identify the misuse of prohibited and licensed chemicals in bovine and equine animals. The new services which the SME partners will obtain from the project will offer an innovative approach to drug analysis based on the monitoring of biological responses to drug use in animals rather than on the direct detection of compounds which forms the basis of current testing. The administration of both legal and illegal drugs to animals destined for food production and performance sport competition continues to be an enormous challenge. Current testing typically analyses individual samples for a single specific drug and thus is inefficient and costly. These limitations have become evident through sport anti-doping enforcement where similar testing has proved ineffectual with individuals proven to have continually evaded detection despite sustained testing. These challenges have been identified by SME partners as challenges to their long-term business sustainability. DeTECH21 aims to deliver new services to increase SME competiveness, service cost-effectiveness and market reach. This will be achieved through the use of the skills of RTD partners in innovative sample profiling techniques and the skills of SME partners in the commercial provision of analytical services. The uniqueness and innovation of the DeTECH21 project will lie in the construction of metabolomic databases which can be used to identify animals which have been exposed to exogenous substances and assist in the identification of administered compounds. This 2 year project brings into collaboration key partners from across Europe who have come together with the joint objective of deliver
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Baltic basin case study' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

To review and expand environmental research on the Baltic Basin, with special regard to socio-economic aspects; to develop a framework for sustainability in Baltic Europe, including maintenance of maximum flexibility for alternative future use, long-term economic development and preservation of the environment.The project is composed of the following:  i) build an information base which describes the essential characteristics of the Baltic Basin and its natural resource use patterns, and provides a basis for subsequent evaluations of their associated sustainable practices and policies;  ii) describe alternative practices and policies required for achieving sustainable ecological systems;  iii) evaluate current practices and policies from multiple points of view to ascertain their sustainability;  iv) recommend mechanisms for promoting the implementation of these practices and policies as appropriate to each region;  v) identify research priorities needed to address unanswered questions about sustainable ecological systems.  These activities will be focused on a few selected ecosystems or watersheds, with a prevailing activity, such as  forestry, industry, agriculture. A whole array of stakeholder groups will be involved: scientists, resource  managers and users, decision makers, citizen groups.  Commissioned papers on critical problem areas, seminars, hearings, and workshops create the bases for the final  products that include:  i) mechanisms for conflict resolution in the field of natural resource conservation, restoration and management;  ii) easy accessible information base on how to approach sustainability for decision makers;  iii) methods for linking of sustainable practices and policies at different scales and among different  stakeholders;  iv) recommendations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nexus framework for biodiversity-relevant transformative change' (BIOTRAILS).

assistant: **Innovation**

BIOTRAILS aims to generate knowledge and develop tools that will inspire and accelerate biodiversity-relevant transformative change in our society. BIOTRAILS will use Participatory Systems Dynamics Modelling to take into account the complex interrelations between the indirect drivers of change in four value chains of traded products (cocoa produced in Peru; forest-based cultural products created by indigenous communities in the Brazilian Amazon; fisheries and aquaculture products supplied by the Mediterranean basin and consumed within the Mediterranean countries; and gold mined in Ghana), and in an integrated manner alongside the climate and social justice agendas. Based on this knowledge and tools, BIOTRAILS will bring together stakeholders across different stages of product/material global value chains to collaboratively design pathways that can lead to a sustainable future, proposing interventions in policy, urban consumption patterns and corporate policies. BIOTRAILS will set up Learning and Action Alliances: groups of organisations and individuals with a common interest to address the multiple challenges of climate change, biodiversity loss and people’s good quality of life, across different spatial and administrative scales and stages of global value chains. Environmentally Extended Multi-Regional Input–Output analysis and Life Cycle Assessment methods will be used to trace the environmental pressures arising from extraction / production, trade, and consumption activities, and behaviour patterns along global supply chains in the target sectors. The project will assess, besides the economic values, the biophysical, social and relational values emerging across different steps of value chain. Behavioural studies will be conducted based on the Theory of Planned Behavi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Networked Audiovisual Media Technologies' in the context of a Sixth Framework call.

assistant: **Objectives**

VISNET II builds on the success and achievements of the existing VISNET NoE to continue the progress towards achieving the NoE mission of creating a sustainable world force in Networked Audiovisual (AV) Media Technologies. VISNET II is a network of excellence with a clear vision for integration, research and dissemination plans described in various sections of this proposal. The research activities within VISNET II will cover 3 major thematic areas related to networked 2D/3D AV systems and home platforms. These are: - Video Coding - Audiovisual Media Processing - Security  VISNET II brings together 12 leading European organisations in the field of Networked Audiovisual Media Technologies. The consortium consists of organisations known for their proven track record as well as both national and international reputations in audiovisual information technologies. VISNET II integrates a number of researchers who have made significant contributions to the advance of this field of technology through standardisation activities, international publications, conferences and workshops activities, patents as well as many other prestigious achievements. The 12 integrated organisations represent 7 European states spanning across a major part of Europe, thereby promising the efficient dissemination of resulting technological development and exploitation to larger communities.  VISNET II will continue to be coordinated by the Centre for Communication Systems Research (CCSR), a part of an academic school at the University of Surrey that is heavily involved in EU IST projects and is one of the 2 only universities in the UK which have achieved a 5*A ranking in the last RAE (Research Assessment Exercise) carried out for UK universities. VISNET II has a demonstrable plan of activities involvi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on ''Tissue is the issue': a multi-omics approach to improve prostate cancer diagnosis'.

assistant: **Concept**

Overtreatment in prostate cancer (PCa) is a burden for health care economy and for quality of life. Correct diagnosis of early stage PCa is challenging given the limitations of the currently available clinical tools and the biological understanding of PCa. In this inter-disciplinary project, I propose an innovative approach enabling several cutting-edge ‘omics’ technologies (spatial metabolomics, genomics, transcriptomics) as well as histopathology to be performed on the same tissue sample. My goal is to reveal the molecular mechanisms of novel, but also promising metabolite biomarkers (citrate, polyamines, succinate and zinc) and their connection to recurrence, tissue heterogeneity and immune responses in complex human tissues. Such markers can personalize PCa diagnosis, open up new treatment strategies and fundamentally change the view of how to analyze tissue samples in the future. Furthermore, I want to demonstrate that citrate and polyamines are reliable prognostic markers that can be analyzed both in tissue and in patients in vivo by MR spectroscopic imaging. This work is made possible by the availability of high-quality fresh frozen tissue biobanks of prostatectomy biopsies with 5-10 years of follow-up data (N=1000)/slices (N=1000) and targeted in vivo snap-shot biopsies from clinical MR guided procedures (N=100). Among other techniques, I will implement high speed MALDI imaging (RapifleX MALDI TissueTyper) to the multi-omics protocol to study the spatial distribution and provide high resolution metabolic maps for each cell type, and which can be matched to both histopathology and MR Imaging. Multi-disciplinary platforms on large cohorts are needed to explore the clinical potential of the suggested molecular mechanisms. I expect that this ambitious proposal will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Interoperability Profiles for Command/Control Systems and Sensor Systems in Emergency Management' (C2-SENSE), addressing dissemination and exploitation.

assistant: **Impact**

Effective management of emergencies depends on timely information availability, reliability and intelligibility. To achieve this, different Command and Control (C2) Systems and Sensor Systems have to cooperate which would only be possible through interoperability. However, unless standards and well-defined specifications are used, the interoperability of these systems can be very complex. To address this challenge, in C2-SENSE Project, a “Profiling” approach will be used to achieve seamless interoperability by addressing all the layers of the communication stack in the security field. In this respect, C2-SENSE project's main objective is to develop a profile based Emergency Interoperability Framework by the use of existing standards and semantically enriched Web services to expose the functionalities of C2 Systems, Sensor Systems and other emergency/crisis management systems. This will be developed in three steps: (1) first, an Emergency Domain Inventory will be created by surveying existing standards, real life use cases of sensors, devices, C2 systems and emergency management architectures for different scenarios in security field.  (2) Based on this inventory, a common Emergency Domain Ontology will be developed to gather all stakeholders' knowledge in a unique and flexible data model. (3) Finally, by using the concepts in this ontology, by also taking into account both functional and operational requirements as well as different countries' cultural, linguistic and legal issues, Emergency Interoperability Profiles that will constitute the framework will be developed. The necessary standardization activities will be initiated to evolve C2-SENSE Emergency Interoperability Framework into a standard specification for interoperability between Sensor Systems and C2 Systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A Space Warehouse Concept and Ecosystem to Energize European OSAM' in the context of a Horizon Europe call.

assistant: **Objectives**

Implementing sustainable commercial activities in Earth orbit requires not only the key technologies necessary to offer the targeted services (OOS / ISAM) but also the means to effectively ensure the (re)supply of the associated facilities. Storage and handling of goods and resources in orbit, in support of OOS or ISAM, have received limited attention in the perspectives and roadmaps of the major future space ecosystem and economy players.STARFAB aims to explore a novel concept of an automated orbital Warehouse Unit (WU) within the context of both OOS and ISAM (also known as OSAM) commercial perspectives. It seeks to address a critical gap in the future space ecosystem, serving as an enabler for sustainable OSAM business models.The STARFAB project will develop a Phase A equivalent concept and demonstrator of an orbital Warehouse Unit (WU), drawing inspiration from the state-of-the-art automated warehousing practices on Earth, while considering the challenging environmental conditions encountered in space, such as microgravity, vacuum, extreme temperatures, and radiation. STARFAB's objective is to advance the necessary technologies for handling goods in space (including modular and custom-shaped components, raw materials for manufacturing, fuel, water, and more), using robotics and automation. This will encompass storage elements with varying levels of protection, the Items Handling Solution (IHS), featuring custom automation tools for operations within the warehouse structure, and the Item Transfer System (ITS), designed as a robotic manipulator to provide flexible external item transfer within the WU. The STARFAB concept will also include provisions for robotic inspection and minor maintenance tasks, primarily for STARFAB's own integrity but possibly also as a service