RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Supported Porous Nanoparticles for Functional Plasmonic Materials' (PlasmoPore) under Horizon 2020.

assistant: **Objectives**

Localized surface plasmon resonance (LSPR) occurring in metal nanoparticles has opened the door to the realization of fascinating novel concepts and technologies. This is possible due to the unique properties of the light-metal nanoparticles interaction mediated by LSPR, for example the efficient light absorption and scattering by metal nanoparticles at resonance, as well as enhanced electromagnetic fields in the vicinity of the nanoparticles. A particularly interesting, yet rarely explored nanoparticle feature with great potential for the creation of plasmonic nanostructures with novel functionalities is porosity, which exhibits numerous so-called ""hotspots"": regions where the local electromagnetic field is greatly enhanced with respect to the incoming field. Combined with large surface-to-volume ratios, porous metal nanoparticles offer potentials for e.g. sensing and plasmon-mediated catalysis applications. Despite these prospects, porous nanoparticles have so far been rarely exploited due to the fact that they are produced via colloidal synthesis, which introduces several limitations.The objective of the proposed research is to establish a nanofabrication route, by combining nanolithography and wet chemical route, to produce supported array of porous plasmonic nanoparticles with excellent dimension control and utilize these nanostructures in the fields of plasmon-mediated catalysis and plasmonic hydrogen sensing. The action will combine the researcher expertise in nanofabrication, experimental plasmonics and hydrogen sensing and the supervisor and host institute experiences in wet chemistry, single-particle spectroscopy and plasmon-mediated catalysis. The successful results of this action will contribute to the development of new class of materials, that is support
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Sexual Plant Reproduction – Seed formation' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

By 2050, it is estimated that the human population will reach 9 billion. To feed this growing population, it will be necessary to at least double agricultural yields, without increasing the amount of arable land. Understanding the factors that regulate sexual reproduction will enable this critical aspect of agricultural production to be engineered for increased productivity, without increasing arable land. Our project will provide new insights into the network controlled by SEEDSTICK (STK), a MADS box transcription factor, which is the master regulator in the production of seeds. The objective of this proposal is to strengthen research partnerships through staff exchanges and networking activities, at international and intercontinental levels. By combining transcriptomic and genetic approaches, we aim to uncover new functions for STK targets and implicate them in putative signalling cascades, increasing our knowledge on the network that controls seed formation in Arabidopsis. Arabidopsis is an excellent model to study seed formation, as it shares a conserved developmental program with major seed-producing crop plants, important to improve not only gross agricultural productivity, but also the composition of seeds and hence the production of components used for high added-value seed-derived products. The growing importance of seeds and seed-derived products to humanity and the central role of STK in seed development means that this project has great potential to contribute to Europe’s excellence and competitiveness in the world.Detailed analysis of the network of regulatory genes controlling reproductive development in Arabidopsis represents the biological theme around which our training programme will be built. By taking advantage of the scientific competences developed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'INNOVATIVE DIGITAL SUSTAINABLE AGGREGATES SYSTEMS' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The European aggregates extractive industry is, by far, the biggest non-energy extractive industries in the EU (Eurostat 2017): 26000 estimated extraction sites: 81,26% of the total EU mining and quarrying sites, 3000 million ton extracted and supplied to the EU internal market, ~ 220000 persons directly employed. Hence the EU faces the need of sustainable and competitive future for European Raw Materials specially in the construction sector due to a greater anticipated demand for products linked to human well-being, health, safety and sustainability. DIGIECOQUARRY will exploit the aggregates industry´s great potential through a coordinated approach towards construction materials management with the final goal of reducing EU external supply dependency as well as leading an efficient use of resources. DIGIECOQUARRY will develop systems, technology and processes for integrated digitisation and automation real-time process control, to be piloted in 5 EU quarries with the target of improving health and safety conditions for workers. The pilot campaigns will lead to improved efficiency of processes maximizing quarry resources and sustainable management of water, energy emissions, minimised environmental impact and expanding the EU aggregates and construction business. Coupling Artificial Intelligence approaches with cyber-physical systems and the Internet of Things concept, make Industry 4.0 approach possible and the smart sustainable extractive site a reality.  All phases of the process, from extraction to the end user are covered by DIGIECOQUARRY, ensuring communication with policy makers, social awareness activities and international cooperation with Colombia and South Africa to share knowledge and best practices. The development of innovative an Intelligent Quarrying Sys
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Generation of safe and efficient, off-the-shelf, chimeric antigen receptor (CAR)-engineered T cells for broad application'.

assistant: **Objectives**

The feasibility and effectiveness of adoptive T cell therapies for cancer has now been proven in several clinical settings. Yet, the current approaches are still “individual-tailored” and thus, their progress and broader use is limited. Having rapid access to “off-the-shelf”, safe cellular products, which can be applied across histocompatibility limitations, would greatly benefit the broader applicability of adoptive T cell therapy. To this end, the applicant recently reported, in a proof-of-concept study, that genetic engineering of T-cell derived induced pluripotent stem cells (TiPSC) with Chimeric Antigen Receptors (CARs) can be an efficient strategy to concomitantly harness the unlimited availability of induced pluripotent stem cells and direct the specificity and functional potential of TiPSC-derived T cells in an HLA-independent manner. Based on this technology, this proposal aims to further investigate novel stem cell genetic engineering strategies in order to obtain in vitro, unlimited, safe and broadly applicable T cells targeting Multiple Myeloma (MM). We propose to target MM with a novel CD38-targeting CAR (CD38CAR). Since CD38 is not a MM-specific target, we aim to simultaneously tackle the on-target/off-tumor toxicity by introducing a drug-regulated expression of CD38CAR. In addition, we aim to use the CRISPR/Cas9 system to achieve targeted knockout of the endogenous T cell receptor (TCR) and the HLA antigens on the CAR-engineered TiPSCs (CARTiPSC) in order to extend the applicability of CARTiPSC-derived T cells across HLA-barriers. The success of this proposal will lay the foundation for further translational application of CARTiPSC-derived T cells cells and investigation of new strategies to enhance their effector function and persistence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of optical NDT techniques and automated defect detection' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

This project aims to- Develop NDT optical methods far beyond existing capabilities, in particular, moiré interferometry and speckle shearography.- Develop automated defect recognition and auto-sentencing algorithms used in interpreting NDT images.High-density moiré has been used in characterising nano and micro scale mechanical behaviour of materials in previous work. This project seeks to build on and extensively develop this work so as to transport the method from optical laboratory and render it suitable for detecting flaws in engineering structure and materials during manufacture and in-service.Efforts will be focused on improving a technique--deformed specimen grating replication--for in-situ measurements and developing algorithms to enhance the fringe quality. Speckle shearography has been shown to detect successfully defects in composite materials but results can be very subjective and requires skill and experience to correctly characterise indications.Here the emphasis will be on optimising t he associated optical set-ups, developing new algorithms to improve defect detection and characterisation, and improving repeatability and ease of use.The project will also seek to develop algorithms for automated defect detection. Methods such as multi-variant analysis and neural networks etc will be used to automatically analyse NDT images to identify potential defects.The host organisation, TWI, has been working closely with SMEs across Europe to develop new NDT techniques for many years. Projects have successfully involved the whole supply chain including SMEs, RTDs and LE end users. TWI's 6500 membership base will ensure that the fellow will be exposed to a wide range of potential contributors and end users.This project will benefit end-users across a range of industri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Are Heat Shock Protein 90 (Hsp90) Co-Chaperones Virulence Factors in the Human Fungal Pathogen Candida albicans?'.

assistant: **Objectives**

Most women will suffer at least one Candida albicans infection in their life. While the majority of infections are not life-threatening, 50% of systemic infections in immunocompromised patients are lethal. Treating C. albicans is challenging due to the close association with its human host, paucity of drug targets and drug resistances. The conserved essential heat shock protein 90 (Hsp90) governs virulence, morphogenesis and drug resistance in C. albicans. Yet, Hsp90 inhibition during mouse candidemia caused host toxicity.Hsp90 does not operate alone. In C. albicans it associates with ten co-chaperones. In C. albicans but not its non-pathogenic relative Saccharomyces cerevisiae, co-chaperone genes are close to telomeres, which is reminiscent of virulence genes in other pathogens. By targeting virulence genes, instead of essential genes, C. albicans virulence could be decreased without reducing its fitness, which would alleviate selective pressure favoring drug resistance mutations. Thus, are C. albicans co-chaperones virulence factors that could be exploited as drug targets?Hsp90 co-chaperones will be investigated in three objectives: (1) Quantify the impact of Hsp90 co-chaperones on fungal virulence. Gene deletion mutants will be tested in four virulence assays. (2) Determine the causes and consequences of the telomere proximal localization. Loss-of-heterozygosity (LOH) and transcriptional silencing will be measured in wild type as well as LOH and silencing mutants to determine cause of proximal telomere location and consequences on virulences. (3) Elucidate the transcriptional regulation of Hsp90 co-chaperone genes. Co-chaperones will be screened for transcription factor (TF) binding sites and ChIP-seq conducted on TFs controlling co-chaperone expression.Understanding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Collective work science approach to solving the common problems of occupational health and performance in European forest operations SMEs'.

assistant: **Concept**

COMFOR will carry out research to develop an innovative knowledge transfer concept on behalf of forest operations SMEs. This will enable the adoption of ergonomically effective work practices and mitigate the problems of poor occupational health and economic performance. COMFOR will create added value through a more competitive and sustainable forestry workforce. The change to out-sourcing of forest operations mechanised harvesting and poor financial returns are having a major effect on forestry SMEs throughout Europe. As a result of these structural changes, the occupational health problems in forestry work and economic pressure on SMEs are increasing. Current ergonomic research provides answers for healthier working practices which also improve performan ce. However, putting science into practice is difficult for these SMEs who face practical and financial barriers to change their way of working and are not in a position to undertake research and development themselves. To achieve its objective, COMFOR ha s gathered a consortium of 10 core SMEs, led by two IAGs, three university and six field-based RTDs from across North, West Central and East Europe. The consortium, directed by the core SMEs will undertake a 3 year pan-European project of integrated work s cience research linked to the most effective ways of transferring knowledge to forestry operations SMEs. This will include new research into the impact of structural change across the European wood supply chain, the economic benefits of ergonomic investmen t and the learning patterns of SMEs. The main output will be an innovative knowledge transfer package for the improvement of health and performance, customised for SMEs operating in three European regions. Core SMEs will trial the knowledge transfer packa ge and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A novel neurotrophin-signalling pathway that controls gene expression in neurons' (2002-2006).

assistant: **Concept**

The ability to detect extra-cellular stimuli and execute appropriate responses is crucial to all cellular functions. Neurons are specialized, morphologically complex cells that represent the functional unit of the nervous system. Neurons are equipped to respond to a variety of cues that direct proper intercellular wiring during development and the maintenance of long lasting synaptic changes during adult life. Mature neurons that have lost the ability to respond adequately to physiological cues or have became unable to overcome stressful stimuli undergo degenerative changes that result in abnormal function and eventually death. Neurotrophins comprise a family of peptide growth factors that sculpt the vertebrate nervous system by regulating cell growth, survival, proliferation and differentiation. One key nuclear target of neurotrophin signalling is the transcription factor CREB. I have previously shown that CREB plays a central role in mediating neurotrophin functions, supporting survival and growth of peripheral neurons.However, the mechanisms by which neurotrophins regulate such diverse responses and the nature of the underlying nuclear changes are still largely unknown. I have recently obtained preliminary data that a novel, neurotrophin-regulated red ox signalling pathway is involved in modulating nuclear responses in neurons under physiological conditions. In particular, neurotrophin-dependent synthesis of nitric oxide and reactive oxygen species (ROS) regulate gene expression by inducing CREB-DNA binding and initiation of transcription.The goals of this project are:1) To characterize the early events leading to neurotrophin-dependent regulation of redox signalling in neurons.2) To identify the nuclear targets and the nature of posttranslational modifications occur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ECO-INNOVATE-AQUACULTURE-SYSTEM' in the context of a Horizon 2020 call.

assistant: **Objectives**

The EASY Project has as its main objective the establishment of a technology that reflects the strategic guidelines for sustainable and profitable development of aquaculture in the EU. In order to follow these guidelines, this project has developed an innovative focused on the development of organic aquaculture feed formula. This formula completely excludes fishmeal and fish oil in its composition, and makes up to 50% cheaper production costs in our product (Tilapia fresh), allowing us to provide the end user, a product with high quality, traceability and profitability. Although Global aquaculture production is increasing, particularly Asian production, European production is stagnated. In EU Countries there is a strong trend in healthier and higher quality fish consumption, furthermore, consumer are requesting fast and comfortable food products without compromising its quality and safety. Obtaining raw material (spirulina and quinoa) inside of our facilities for the production of feed, along with the use of new technologies in the field of aquaponic, is undoubtedly the main key to the viability (feasibility) of EASY Project. The opportunity that this tool SME (Horizon 2020) offers drives the growth of the European inland aquaculture, create new jobs and position us as a world-leader in sustainable aquaculture. Analyzed by University of Murcia the results describe our fish as a very high quality due to the organoleptic properties, and perfectly suitable for the new market challenges. In Phase I our principal aim is to conduct a feasibility study including a business plan and market research with our partners regarding commercialization of the products, specially V range products (new formats), taking advantage over our Asian competitors, thus, becoming a leader in this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a low cost non- destructive inspection equipment to improve the assessment of tyre casing integrity' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Over 1000 EU SMEs are involved in tyre retreading and supply to this industry. Retreading is the process of recycling a used tyre via removal of the worn tread and addition of new tread. During the process each used tyre must be inspected to determine whether it is fit for retread or should be scrapped due to irreparable damage.  The inspection process begins with a visual inspection and is generally complemented by further inspection using non-destructive test equipment. Currently available commercial equipment, such as x-ray, shearography and ultrasound, is too costly for SMEs, bulky, time consuming and in many cases proprietary- developed by the major manufacturers for their exclusive use.  EU tyre legislation means that dependency on the experience of qualified operators is no longer sufficient in assuring tyre quality thus leaving retreading SMEs in a critical situation. A real need has been manifested by Retread Associations for a fast, easy to use, low cost casing inspection machine to enable their SME retreaders to secure retread quality and avoid wasting resources on unsuitable casings.  This project will develop a tyre casing inspection machine (tyretest) to complement the manual inspection of used truck casings in order to reduce operating costs, consistently deliver product quality and safety, as well as promote the recycling and reuse of tyres. The use of pulse-echo ultrasound will represent a real innovation and Tyretest will perform non-destructive inspection of the tyre sidewalls, shoulders and crown area in a total test time of 1.5 minutes.  The inspection is designed to identify any internal tyre defects which could render the retreaded tyre unfit for use. Introducing a low cost and easy to operate inspection technique would enable SMEs to become more