RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'REFRAMING NON-METROPOLITAN LEFT BEHIND PLACES THROUGH MOBILITY AND ALTERNATIVE DEVELOPMENT' (Re-Place), addressing dissemination and exploitation.

assistant: **Impact**

Peripheral non-metropolitan areas are the subject of narratives with different degrees of pessimism. The pessimistic view relates to the hotspots of discontent that have arisen across Europe and the optimistic view to revitalized visions of small cities and rural localities as offering a higher quality of life in pandemic times than the metropolitan centres. Both views point to the complexity in deciphering the role spatial mobilities play in the future of peripheral places traditionally victims of outward migration and a lack of investment in economic and social infrastructure. Re-Place will study the dual function of places as areas of origin and destination focusing on heterogeneous forms of dwelling enmeshed in place. The overall objective is to mobilize participative research in non-metropolitan left-behind areas (LBAs) to examine the impact that spatial (im)mobility has on origin and destination areas and how it can be harnessed to improve local alternative development, cooperative building of human capital, wellbeing and sustainability across contexts. It will reach this through five specific objectives: i) to develop empirical tools – namely a typology and an online representative population survey- to advance complex understandings of development pathways and mobility; ii) to scale down to 12 areas in 6 countries to examine the (im)mobility drivers and movement to and from different types of LBAs assessing ensuing spatial, economic, social, and cultural transformations; iii) to qualitatively examine perceptions and livelihood practices of (im)mobile residents across life domains to understand micro strategies of dealing with peripherality; iv) to co-create place-based policies to enhance mobility benefits and alternative local development through village living
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Fuel Recycle and Experimentally Demonstrated Manufacturing of Advanced Nuclear Solutions for Safety'.

assistant: **Concept**

FREDMANS aims to increase safety and efficiency in both nuclear power production as well as the recycling of spent fuel. Changing from oxide fuel to a more fissile dense material with higher thermal conductivity can enhance both safety of operation and the economic impact of nuclear power. At the same time, a transition to a greener society with respect to both the generation and usage of electricity will drastically increase consumption of finite materials. Generation is predicted to increase by 16?20 times, in particular as electrification replaces the direct use of fossil fuels for heating and transportation. The nuclear industry can mitigate their part of the resource use through the recycling of spent nuclear fuel. This can enhance the actual power output by about 20 times. However, today there has been no full industrial demonstration of the complete recycling of nuclear fuel, although one time recycling, including of plutonium, has been used on large scale for many years e.g. in France. The model fuel is nitride fuel. It may be more energy efficient/economically advantageous to recycle not only the fissile material, but also the required isotopically enriched N-15 that is otherwise currently a costly raw material.The project sets objectives that address the overall goals of the SET plan, SNETP and EERA JPNM SRA to answer the specific aims of this call relating to the safety of advanced fuels and their recyclability, in particular nitrides highlighted in the call. We will prove that advanced fuels are a viable option for industrial use that can enhance the safety, sustainability and economics of nuclear power operation.The work packages are: Advanced Manufacturing, Recyclability, Waste Management, and Industrial Applications. Across all these WPs, the crucial aspe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deciphering the molecular language orchestrating host-microbiome interactions and their effects on health and disease' to be submitted under Seventh Framework.

assistant: **Abstract**

The gastrointestinal tract hosts the microbiome, one of the highest microbial densities on earth. Diverse host-microbiome interactions influence a multitude of physiological and pathological processes, yet the basic mechanisms regulating host-microbiome interactions remain unknown. Deciphering the codes comprising the host-microbiome communication network and factors initiating loss of homeostasis (termed dysbiosis) will enable the recognition of pathways and signals critically important to initiation and progression of common immune and metabolic disorders. We recently identified the NLRP6 inflammasome as a critical innate immune regulator of colonic microbial ecology, with its disruption resulting in auto-inflammation and tumorigenesis. We will use this unique system, coupled with innovative robotic high-throughput modalities, gnotobiotics, metagenomics and multiple genetically altered mouse models to generalize our studies and decipher the critical principles governing host-microbiome interactions. We will elucidate the host-derived microbiome recognition signaling pathway at its entirety, from its upstream activators to the downstream effector molecules controlling microbial ecology; uncover the principles generating a stable microbiota composition; and develop and apply computational modelling to dissect the general mechanisms disrupting microbiome stability leading to dysbiosis. Using this innovative experimental and computational toolbox we will study the impact of dysbiosis on key components of the metabolic syndrome, and apply our findings to devise the first rational proof-of-concept approach for individualized microbiome-based treatment for these common disorders. At the basic science level, unraveling the principles of host-microbiota interactions will lead
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Inside mechanisms sustaining cancer stem cells' (InMec).

assistant: **Innovation**

The “Cancer Stem Cell (CSC) Hypothesis” postulates that the capacity to maintain tumour growth is owned by rare cancer cells, the CSCs, endowed with self-renewal properties. This hypothesis implies that CSCs must be eliminated to achieve cancer cure. Nevertheless, direct proof is still lacking, and recent findings challenge our concepts of CSCs, showing the limits of the CSC-defining assay (transplantation) and suggesting that CSC-identity might be context-dependent. We found two properties of CSCs self-renewal that are indispensable for the maintenance of an expanding CSC-pool and tumour growth: increased frequency of symmetric divisions, due to inactivation of the p53 tumour suppressor, and increased replicative potential, due to up-regulation of the cell-cycle inhibitor p21. We will now investigate: i) How loss of p53 in tumours leads to expansion of the CSC pool, by testing the hypothesis that p53-loss activates the Myc oncogene which induces CSC-reprogramming of differentiated cancer cells. ii) Whether p53-independent pathways are also implicated, by in vivo shRNA screens of primary tumours or normal progenitors to identify pathways involved, respectively, in CSC self-renewal or inhibition of SC-reprogramming. iii) How p21-induced cell-cycle arrest protects CSCs from self-renewal exhaustion, by investigating regulation of cell-cycle recruitment of quiescent CSCs. iv) Whether activation of p21 in CSCs induces a mutator phenotype, due to its ability to activate DNA repair, by investigating mechanisms of DNA-damage, mutation rates, and relevance of CSC mutations for development of chemoresistance. We will test self-renewal functions in a transplantation-independent assay, based on tumour re-growth in vivo after cytotoxic treatments and “clonal tracking” of re-growing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Policy influences on technology for agriculture - chemicals biotechnology and seeds' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Technological innovation in the agrochemical, biotechnology and seeds industries and in associated public sector research establishments (PSREs) has the potential to deliver more socially and environmentally sustainable farming systems and to improve the quality of life in Europe. However, interactions and gaps in the policy, regulatory and market environments of these organisations can discourage or delay such improvements. The project will investigate these issues as follows: (i) a study of major influences on industry and PSRE decision making, including policies and regulations at national, regional and EU levels, as well as the demands of food processors, retailers, public opinion and attitudes (market-related factors); (ii) (the core of the project) an investigation of the impact of such issues on the strategies and decisions of companies, trade organizations and PSREs, focusing on decisions about product development, levels of investment and location of investment; and (iii) a study of the outcomes of these decisions, as reflected in effects on European and international competitiveness, employment levels and the sustainability and biodiversity of European intensive agriculture. The results from the project will be fed back to policy makers at national and EU levels and to managers in companies and PSREs to facilitate future development and implementation of policies in these areas. Partners will be based in the UK (including overall coordination), Netherlands (including coordination of policy-related research), France (including coordination of industry studies), Spain and Denmark. Deliverables will include reports on policy and market-related factors relevant to decision making in industry and PSREs, reports on strategic decision making in industry and its outco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'REAL-WORLD IMPLEMENTATION, DEPLOYMENT AND VALIDATION OF EARLY DETECTION TOOLS AND LIFESTYLE ENHANCEMENT' (AD-RIDDLE), addressing dissemination and exploitation.

assistant: **Impact**

Alzheimer's disease (AD), the main cause of dementia, is one of the major global health challenges of our time. This disabling disorder affects 55 million people worldwide, with costs above $1.3 trillion. With 67 million people at risk for AD dementia (prodromal and preclinical AD) in Europe alone, it is a major unmet public health need, with increasing burden for European economies, healthcare and social care systems and a concern for the future. Yet, prevention and early detection strategies have been lacking. Recent advances in disease-modifying therapies and the huge potential benefits of preventive multidomain interventions based on modifiable lifestyle and vascular factors (prevention potential ~ 40%) provide new opportunities. New developments in blood-based biomarkers (BBMs) and digital cognitive tests enable broader, cost-effective testing. The AD-RIDDLE platform is envisioned to revolutionize how AD is detected and diagnosed, prevented and treated across healthcare settings (HCS). AD-RIDDLE centres around a toolbox platform concept, providing a series of validated tools at each key step to enable HCS and practitioners to deploy enhanced AD management across diverse patient populations. The AD-RIDDLE toolbox platform will include a) community outreach tools to increase awareness/activation on AD prevention; b) combination of easily available, clinically validated biomarkers: digital cognitive tools and BBMs, for early detection of AD dementia risk; c) validated algorithms supporting clinical decisions, to identify people who can benefit from specific preventive therapies (pharma and/or non-pharma) using precision prevention approach. The toolbox usability and efficacy with be tested in real-world settings. We expect that the AD-RIDDLE modular and flexible desig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Characterization of the chlamydia containing vacuole and its interaction with other intracellular compartments' under Fourth Framework.

assistant: **Concept**

Chlamydiae are obligate intracellular bacteria occupying a vesicle called an inclusion throughout their life cycle. They evade lysosome destruction by inhibiting fusion of the inclusion with lysosomes. There is very little information on the origin of the vacuolar membrane surrounding the chlamydiae or the properties of the compartment in which they proliferate. Additionally, little is known about the role of the cytoskeleton in chlamydiahost cell interaction. My proposed project concerns the intracellular survival of chlamydiae. The subcellular compartment(s) in which chlamydiae survive will be characterised by 1) following the distribution of specific intracellular organelle markers of the host cell in the chlamydiae compartment(s) and 2) measuring the pH of these vacuoles. In addition, the mechanism whereby chlamydiae avoid lysosomal destruction and the role of cytoskeletal elements in the formation of the chlamydia inclusion and the chlamydia infectious cycle will be investigated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Developmental neurotoxicity assessment of mixtures in children' (DENAMIC), addressing dissemination and exploitation.

assistant: **Impact**

Various recent epidemiological studies have indicated that exposure to low doses of environmental biologically active contaminants during human development can alter gene expression and have deleterious effects on cognitive development in childhood. The DENAMIC project is ultimately focused on reducing such effects of environmental contamination on learning and developmental disorders in children. It aims to study and evaluate environment-health relationships in children. Key elements are: development of sophisticated tools and methods for early warning and screening of compounds for neurotoxicity, to study mechanisms of disease development and the role of individual susceptibility, to improve assessment of exposures and effects, focus on combined exposures to environmental agents that can interact to enhance adverse effects and reduction of health inequalities of children through Europe. One of the main aims of DENAMIC is to develop tools and methods for neurotoxic effects of mixtures of environmental pollutants at low levels, possibly resulting in (subclinical) effects on learning (cognitive skills) and developmental disorders in children (e.g ADHD, autism spectrum disorders and anxiety disorders). A broad suite of contaminants will be included in the studies, with options to bring in new chemicals in case evidence comes up during the project. With 14 partners from ten different countries DENAMIC has a true international character. It is a comprehensive, multi-disciplinary project. Six SME’s will play a key role in the development of biotechnological screening tools. The most modern techniques in the fields of genomics, proteomics, metabolomics and transcriptomics will be applied. Dissemination will ensure the project results to arrive at policymakers' desks, and will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'DEVELOPMENT OF A NEW AUTOMATED MACHINE TO UNWRAP PALLETS EFFICIENTLY AND SAFELY' (AUNPALL), addressing dissemination and exploitation.

assistant: **Impact**

Located in Emilia Romana, EMMETI is a world leader in the field of palletization and depalletization thanks to its vastexperience and the high quality standards of its machines. In the last 5 years, our sales figures have reached € 30 million.Established in 1976, and thanks to the huge investments made in the past, and with more planned in the future, EMMETIguarantees consistency of its high technological standards and the competitiveness of its products in a market that continuesto demand higher performance. The majority of our quality work is based on long-term relationships with key customers whorely on our company to find solutions that provide added value to their products in terms of production processes. Ourcustomers require our expertise to provide in-house research and having found some common direction, we wanted to findan effective unwrapping solution that would improve and speed-up production, reduce costs and guarantee safety at workstations. The result is our AUNPALL project, a novel machine which aims to automate the process of unpacking filmwrappedpallets in the packing line before its depalletization, in a rapid, reliable and safe way.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DYNAMIC IMAGE COMPUTING USING TERA-SPEED ANALOGIC VISUAL MICROPROCESSORS' in the context of a Fifth Framework call.

assistant: **Objectives**

DICTAM aims to produce a new class of image-processing systems based on an optimum, adaptive synergy of Analog Programmable Array Processors (APAPs) and conventional DSPs, including concurrent image transduction and processing by means of Focal-Plane APAPs (FPAPAPs). Substantial advantages in computing speed, system cost, power consumption, and overall quality of the processing functions are expected. The tasks include advanced microelectronic circuit design of mixed-signal APAPs, FPAPAPs and image memory devices, development of optimum hardware/software architectures, of system-specific processing algorithms, and the integration of these basic ingredients into several demonstrators. Within the wide range of applications, the project will focus on real-time dynamic image coding, video authenticity and integrity verification, visual inspection in automated production processes, and motion picture related applications. DICTAM aims to produce a new class of image-processing systems based on an optimum, adaptive synergy of Analog Programmable Array Processors (APAPs) and conventional DSPs, including concurrent image transduction and processing by means of Focal-Plane APAPs (FPAPAPs). Substantial advantages in computing speed, system cost, power consumption, and overall quality of the processing functions are expected. The tasks include advanced microelectronic circuit design of mixed-signal APAPs, FPAPAPs and image memory devices, development of optimum hardware/software architectures, of system-specific processing algorithms, and the integration of these basic ingredients into several demonstrators. Within the wide range of applications, the project will focus on real-time dynamic image coding, video authenticity and integrity verification, visual inspection in automated p