RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ecosystem approach to sustainable management of the marine environment and its living resources' (ECOSUMMER).

assistant: **Innovation**

There is an increasing need for the adoption of an ecosystem approach to the exploitation on marine resources, to promote, ecological, environmental, economic and social sustainability and preserve biodiversity. The next generation of marine scientists will need to be fully trained in these concepts. A consortium of eight internationally-recognised universities and marine science institutes in UK, Spain and Greece offers early stage training in a range of topics related to the project theme (e.g. life history biology, population, community and ecosystem ecology, immunology, physiology, molecular genetics, stock assessment, fishery and coastal zone management, fisheries economics, physical oceanography and marine GIS), with particular emphasis on an ecosystem approach to sustainable management of living resources.There partners are University of Aberdeen (including Oceanlab, Lighthouse field stations and the Scottish Fish Immunology Research Centre, UK), Fisheries Research Services Marine Laboratory (UK), Scottish Association for Marine Sciences (UK)Institute of Marine Biological Resources (Greece), Centro Oceanografico de Vigo (Spain), University of Vigo (Spain), University of Aegean (Greece) and Instituto de Investigaciones Marinas (Spain). The proposed project will run for 4 years and offer training periods of 3 to 6 months, with trainees encourage choosing projects involving stays at more than one partner centres. The partnership has extensive research experience and an excellent track record in training early stage researchers, with full quality assurance provisions in place. Training will include a strong element of core transferable sills as well as specialist training. Supervision will be provided by acknowledged experts in each field and trainees have access to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Environmentally friendly and economical gelcasting using natural gelformers' under Fifth Framework.

assistant: **Concept**

'Environmentally Friendly and Economical Gelcasting Using Natural Gelformers' The Flemish Institute for Technological Research (Vito) implements client-driven research projects and develops innovative products and processes. The multidisciplinary skills and technological know-how of a 440 persons strong R&D-community make this organization a crossroads of technology, where state-of-the-art technologies are successfully blended into practical applications. Specific problems are addressed in Vito's 8 so-called 'centres of expertise' dealing with energy consumption in processes, new materials and environmental protection and innovation. One of the 'centres of expertise' is the Materials Technology Centre, with own facilities for analysis and characterization, where a crew of 15 researchers are involved with processing and application of ceramics materials, with focus on colloidal shaping techniques. For enhancing its competence in the field of shaping of ceramics by colloidal near net shaping techniques, more specifically the application of bio-polymers for ' eco-ge casting' of ceramic components, Vito is looking for a , Doctor (M/F) in Biochemistry, Food Technology or Food Chemistry with a background and/or experience in the I field of bio-polymers for a 2-years fellowship. The research fellow is expected to lead work on chemical or physical modifications of biopolymers to enhance the shaping capabilities and the compatibility with the nature of ceramic slurries. He will report his results in written and will give seminars on a regular basis. A good knowledge of English or French is required, and the willingness to acquire a basic knowledge of Dutch during your stay is a plus. If you are interested, please send your application letter and curriculum vitae to Jan Luyten, V
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Neuromuscular-cognitive interactions in sensorimotor decision making' (MYODECISION).

assistant: **Concept**

Successfully interacting with one’s environment requires a rich interplay of perceptual judgement and neuromuscular control, with each taking account of the other in real time. Miscalculations in this accounting, as happens in demanding sensorimotor tasks (e.g. sports), cognitive and motor disorders, or with age-related decline, can have serious consequences. Despite the huge growth in modelling and neurophysiological studies of perceptual decision making, the critical role played by neuromuscular processes has been largely neglected due to challenges in parsing distinct effects of sensory, cognitive and motor processing in the brain. Our recently developed computational framework for jointly modelling behaviour with well-characterised neurophysiological signatures of sensorimotor decision formation now provides a means to overcome this parsing problem, offering a window onto the hierarchy of cortical processing involved. MYODECISION will capitalise on this advance to develop new decision paradigms that interface directly with muscle outputs, making the participants active agents in meeting changing neuromuscular demands, and hence resolve major outstanding questions regarding how sensory and motor systems interact in the brain. First, I will investigate how people adjust sensorimotor processes to meet changing time and effort demands on their motor outputs, including fine-grained manipulations of muscle-activation strength requirements, speed pressure, and effort biases. Then, using open- and closed-loop stimulus perturbations I will probe how these processes underpin dynamic changes of mind that rescue erroneous behaviours. Finally, I will develop a robust approach to neurally-constrained modelling aimed at examining individual differences in decision making in challe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Histone H3.3 oncogenic mutations: a role in genome instability through altered DNA repair and replication fork stability?' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Genome instability is a hallmark of cancer and is caused by the accumulation of DNA damage. Genome integrity is preserved by DNA repair machineries that operate on a chromatin substrate where DNA wraps around histone proteins. Interestingly, point mutations in histone H3.3 in particular have been identified as drivers of tumorigenesis. Beyond their impact on gene expression, some of these mutations were recently shown to inhibit homologous recombination-mediated repair of DNA double-strand breaks (DSBs) in human cells (K36M mutation) and to contribute to replication fork stability in yeast cells (G34R mutation). Furthermore, H3.3 histones are deposited de novo at sites of DNA damage in human cells. These findings call for a more systematic characterization of the impact of H3.3 mutations on genome instability. We hypothesize that H3.3 point mutations may alter the cellular response to DNA damage, thus leading to malignant transformation. Here, we propose to test this hypothesis through a set of complementary approaches in human cell lines. We will initially examine whether H3.3 mutations affect histone deposition at DSBs and at damaged replication forks and chromatin relaxation at DSBs. Next, we will evaluate whether H3.3 mutations affect DSB repair and replication fork stability and repair, ultimately inducing genome instability. We will then evaluate the potential clinical applications of our results by testing whether H3.3 mutations may in turn impact drug sensitivity. These complementary research angles should help understanding whether H3.3 oncogenic mutations affect genome integrity independently of their impact on gene expression, providing new molecular bases for their oncogenic potential. This work might ultimately identify druggable defects that confer chemoth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Plant Ecology for Nitrous Oxide Mitigation and Sustainable Productivity'.

assistant: **Objectives**

Agricultural soils are the dominant source of nitrous oxide (N2O), a potent greenhouse gas as well as a major cause of ozone layer depletion. Recent findings show that combinations of plants with complementary root traits can increase nitrogen (N) uptake leading to lower N2O emissions. Based on the microbiology behind soil N2O emissions and on plant-trait based ecology, this project aims to build on this finding and develop a novel N2O mitigation strategy. We aim to reveal how plants and plant interactions via their traits and trait combinations can be used to reduce N2O emissions in a context of climate change related disturbances (drought and intense rainfall). Starting with microcosm incubations using monocultures of different plant species, we will quantify the relative importance of specific plant traits as means to regulate N2O emissions. An ensemble of inter- and multi-disciplinary techniques will be applied to analyse the ecological and agronomical plant characteristics of potential relevance as well as the plant-specific microbiological communities of importance for the N-cycle. Subsequently, greenhouse mesocosm experiments will be used to expand the acquired knowledge to cover interactions between plants and stresses induced by climate change factors. A meta-analysis of published and unpublished datasets will allow further elucidation of specific and interactive mechanisms, differentiated by environmental and management factors and to include studies over longer time frames. Finally, the generated results will be used to calibrate and validate a process-based model in order to extrapolate our findings to regional levels. Deliverables will be peer-reviewed papers, new experimental data on a new N2O mitigation strategy, improved model tools to simulate mitigatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Irisin - a novel myokine protective against metabolic disease' (2007-2013).

assistant: **Concept**

Cardiovascular disease and diabetes constitute the major disease burden in the western world with growing morbidity. Exercise is known to ameliorate many of the key processes in the pathogenesis of these diseases, but the underlying mechanism is not clear. Especially little is known about how exercise affects non-muscle tissues such as the heart, fat and liver. Knowledge of such pathways could lead to new therapeutic possibilities for diabetes and cardiovascular diseases.I have recently discovered a new hormone, named Irisin. Irisin is regulated by PGC1α, secreted from muscle to plasma after exercise and promotes the formation of brown fat via an unknown receptor. Furthermore, irisin is 100% conserved between mice and humans at the amino acid level (89% identity between zebfrafish and human). Nanomolar levels of this protein increase uncoupling protein 1 (UCP1) in cultures of primary white fat cells by 50 fold or more, resulting in very large increases in uncoupled respiration. Perhaps more remarkable, in vivo delivery of irisin stimulates a robust increase in UCP1, increased energy expenditure and reversal of type II diabetes in high fat fed mice. It is thus likely that irisin is responsible for at least some of the beneficial effects of exercise on the browning of adipose tissues and increases in energy expenditure. The therapeutic potential of irisin is obvious; it is a conserved endogenous polypeptide, induced with exercise and with powerful anti-diabetic properties. Irisin could, for example, be administered exogenously, or the secretion of irisin could be enhanced. These approaches, however, require additional studies, and my aim in this project is to advance the knowledge around irisin for future therapeutic testing.Given success of the ERC grant application, I w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'QUSTEC: international, interdisciplinary and intersectoral doctoral programme in Quantum Science and Technologies' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

QUSTEC offers interdisciplinary, intersectoral and international doctoral training in the field of quantum science and technologies (QST) to 39 early-stage researchers. The coordinator is the European Grouping of Territorial Cooperation (EGTC) Eucor – The European Campus that consists of five universities that are located in the  Upper Rhine research area, at the border between France, Germany and Switzerland. Within QUSTEC programme, the Eucor Members, University of Basel, University of Freiburg, University of Strasbourg and the Karlsruhe Institute of Technology are joined by IBM-Research in Zurich and Walther-Meissner-Institute in Munich. The QUSTEC training programme is in line with the European Charter for Researchers, the Code of Conduct for the Recruitment of Researchers and the EU Principles for Innovative Doctoral Training. Fellows can choose their research projects among the offer of the partner organisations and will be enrolled in a doctoral programme of one of the partaking universities. They are selected in an open, transparent, merit-based procedure based on international peer review. All early-stage researchers are offered a generous 4-year employment contract with the corresponding social security provisions. An individual training panel in a three-tier training programme will supervise them. With a budget of 9 139 308,48 Euro and an overall duration of 6 years, the QUSTEC programme offers one call and one reserve call for candidates from the science, technology, engineering and mathematics (STEM) field. The scientific focus lies on the six areas of quantum electronics, artificial quantum systems, quantum nanodevices, non-equilibrium quantum systems, quantum resources, and quantum simulation. The MSCA COFUND support serves as a nucleus for early-stage re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Burden of disease based methods for estimating the socio-economic cost of environmental stressors' in the context of a Horizon Europe call.

assistant: **Objectives**

The outdoor environment has a significant impact on our health and wellbeing. The European Green Deal has introduced the ambitious commitment to a ‘Zero-Pollution Action Plan for air, water, and soil’ to protect humans and the environment. Evidence-based policy making on environmental stressors is however hampered by the methodological challenges to quantify their socio-economic costs.The overall objective of BEST-COST is to improve methodologies for the socio-economic cost assessment of environmental stressors to i) enhance regular usage of economic and health modelling in policy impact assessments and policy evaluation; and ii) promote harmonised and consensus metrics for integrative socio-economic assessments of environmental stressors in Europe. BEST-COST will develop an improved and consensual burden of disease (BOD) framework for estimating the health impact of environmental stressors, with a focus on air pollution and noise and their interactions; an improved and consensual methodology for monetization of BOD estimates of environmental stressors; and a coherent methodological framework for assessing social inequalities in the socio-economic cost of environmental stressors. The methods will be co-developed with key stakeholders, made available as open access tools, and trialled in different EU countries. To ensure sustainability, transferability of the knowledge and methods developed by BEST-COST to other countries and stressors will be established.BEST-COST is conducted by a strong and unique consortium, gathering world-class expertise on environmental BOD assessment. The BEST-COST consortium consists of 17 organisations from 10 EU countries and the USA, and will be supported by an Advisory Board including representatives from JRC, EEA, and WHO. The consortium br
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European Infrastructure Powering the Internet of Things' (EnABLES).

assistant: **Innovation**

EnABLES will integrate key European research infrastructures in powering the Internet of Things (IoT). 6 research institutes together with 5 knowledge hubs of excellence will address the long term needs of energy management in self-powered smart sensor systems as required by IoT innovation. To enable truly ‘invisible’, unobtrusive and self-powered (autonomous) wireless devices a key challenge is to bridge the gap between capturing energy supply from energy harvesting sources (EH), integrating new devices for energy storage (ES) and taking into account the micro-power management (MPM) requirements for the miniaturised system operation. Through providing access to unique infrastructure, world-leading expertise, advanced equipment and state-of-the-art technologies, EnABLES will empower several hundreds of academic researchers and technologists to advance energy harvesting, storage and micropower management solutions for the integrated design and deployment of miniaturised autonomous sensors. Access will range from materials & models to devices and systems and the access providers will work with the user community to accelerate adoption and innovation in real-life applications. The EnABLES integration offers a paradigm shift in building an infrastructure network that links new scientific knowledge with application-driven research. Specifically for energy management solutions, this will deliver a mind-set change for early concurrent and collaborative development of system-optimised IoT devices. This presents a unique opportunity for Europe to uphold global leadership in microsystem energy management and be positioned at a pivotal time at the heart of the IoT innovation.


**Keywords:** Internet of Things, Energy Harvesting, Energy Storage, Micro-Power Management
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanosensitive proteins as a pathway to mechano-targeted drug delivery' (ForceDelivery) under Horizon Europe.

assistant: **Objectives**

Biophysical research over the last two decades has revealed that an impressive number of mechanical signals are key regulators of cell behavior. So far, the focus has been on understanding fundamental mechanosensing and transduction mechanisms in health and disease. As increasing numbers of molecular players and signalling pathways are identified, the time has come to utilize this knowledge for diagnosing and treating diseases where mechanical processes play a role. In this proposal, I aim to target integrins to deliver reporter molecules and drugs to cells with a distinct mechanical phenotype. Integrins are transmembrane receptors through which cells can sense, transmit and discriminate biomechanical forces. During cell adhesion and migration, integrins engage with specific ligands in the extracellular matrix and undergo integrin recycling through continuous endo- and exocytosis. This known endocytic pathway, integrin clustering during adhesion and overexpression in disease states has made integrins a prime target for drug delivery. However, the chemical and physical factors governing integrin-mediated uptake of drugs and their intracellular fate are unknown. I propose to utilize molecular force sensor (MFS) technology to deconvolute the key factors in integrin-mediated drug delivery. Using rational protein design, a series of coiled coil MFSs with distinct chemical (charge and hydrophobicity) and physical (mechanical and thermal stability) properties will be produced. The molecular constructs will be appended with the integrin-targeting RGD motif, a fluorescent protein to investigate the intracellular fate and an actin-binding protein as a model drug that may potentially interfere with the cytoskeleton architecture. This MFS-based drug delivery system will enlighten t