RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Constructing understandings of homeless populations' (CUHP) targeting Fifth Framework.

assistant: **Abstract**

The proposed thematic network brings together seven teams from Scandinavia, Northern Industrial Southern and candidate (Eastern) EU states with expertise in the field of homelessness research, to share knowledge of robust methodologies, substantive findings and policy outcomes. The multi-disciplinary network has used quantitative and qualitative methods to undertake national and local estimates and surveys of homeless populations, tracked services users, and accessed the voice of diverse homeless populations (gender, ethnic groups, migrants) and initiated debates on theories of social and cultural capital, risk, social exclusion, welfare regimes and biographic analysis in the study of homelessness. The network seeks to draw this knowledge together, to produce seminaries of methodologies used in harmlessness research; of substantive findings and conceptual frameworks, providing guides and sharing knowledge with NGOs, researchers and policy makers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Therapeutic discovery for cholangiocellular carcinoma'.

assistant: **Concept**

Cholangiocarcinoma (CCA) is one of the deadliest cancers comprising a heterogeneous cluster of malignancies that are distinct to hepatocellular carcinoma (HCC) and that can emerge at any point in the biliary tree. While not very common, CCA is responsible for 2% of cancer-related deaths worldwide annually and rising. The incidence in European countries is increasing rapidly ranging from 1 to more than 4 cases/100,000. CCA is mostly diagnosed very late resulting in aggressive disease progression, poor treatment response, and dismal prognosis with a median survival of less than 2 years. Curative hepatic resection is an option in 10-30% cases and is mostly linked to recurrence within 12 months in over 50% of patients. For most patients, diagnosis will occur when the disease is already too advanced, and the only options are chemotherapies or palliative care. Current standard-of-care for CCA is unsatisfactory with very limited efficacy and adverse effects. Recently approved second-line therapeutics slightly improve outcome but are only suited to a small subset of CCA patients. Thus, there is a major unmet medical need for novel therapeutic strategies to improve patient outcome. Based on a robust data package obtained in a panel of CCA models within ERC HEPCIR, here we will explore the use of a novel class of compounds exploiting a unique and differentiated first-in-class mechanism-of-action and validate their efficacy in vivo as a first-line therapeutic for CCA. Proof-of-concept studies will be performed in state-of-the-art patient-derived models combined with scRNASeq and proteomics. The data obtained will serve as a pre-IND data package for this indication. An established collaboration with a pharma partner will ensure fast-track completion of the preclinical development t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Thick oxide films for passive and active optical components' (1994-1998).

assistant: **Innovation**

Thick oxide films for passive and active optical components  High performance low cost passive and active optical components are required for the wide spread use of optical telecommunication networks. At present they are fabricated from planar waveguides consisting of micropatterned and doped glass layers with lateral dimensions of several cm and thickness of 3 to 15mm by expensive deposition and patterning techniques.  The objective of this project is to develop a new low cost technology based on wet chemical processing of micropatterned glass layers for waveguiding at 1.55 mm wavelength and to demonstrate its technical and economical feasibility by three demonstrator devices:a 1:2 splitter with insertion loss < 7 dB a length of < 8 cm and costs < 35 ecu/port,  a planar amplifier with a length of 5 - 8 cm, higher than 10 dB gain for pumping power less than 100 mW, and cost of < 200 ecu,  a wavelength demultiplexer with specifications to be developed by the final user partner. The base line of the project is the experience of the industrial partners involved in planar waveguide production and an already existing nano technology for making thick films SiO2 particulate sols.  The technical innovation claimed is the development of low propagation loss waveguide structures based on silicates and/or phosphates glass layers of 3 to 15 mm thickness by a one step process with a high potential for low cost optical components and high indirect benefits for microsystems technology. The general approach is the use of wet chemical routes for the synthesis and processing of high solid content coatings sols and slurries using fine particles and stabilised suspensions by the appropriate basic technologies. In order to obtain the demanded homogeneity in thickness state of the art coatin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Welcoming immigrants in Central and Eastern Europe: lessons from Russia's invasion of Ukraine' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The negative attitudes towards immigration in Central and Eastern European (CEE) countries were on clear display during the 2015/2016 immigration crisis, particularly in the Visegrád Group countries, but also in the Baltics. Against this backdrop, the overwhelming support for Ukrainians fleeing the war in CEE has come as a surprise to many. It has highlighted the huge inequalities in the treatment of Ukrainians vs. other third country asylum seekers and clearly revealed conditionality of migration and integration systems as well as their potential for change. While there have been countless examples of populist leaders being able to successfullystoke hostility towards immigrants, there is little evidence to indicate what can systematically decrease anti-immigrant sentiments in CEE on such a broad scale.Making use of the unique historical conditions, the project draws from scientific disciplines often overlooked in research on attitudes towards migrants (memory studies, history, security studies, political science, behavioural economics, communication etc.) aiming to generate an original understanding of societal attitudes that go beyond ‘xenophobia’ and ‘prejudice’, and raises broader questions about the relationship between structural, political, cultural, economic, ideological, and agential influences on attitudes towards immigration.The project is based on case studies of three CEE countries (Poland, Latvia, Hungary) and Italy as a benchmark case. While most previous research focuses on negative narratives surrounding immigration, this project seeks to learn from the experience with Ukrainian refugees in CEE and looks for practical solutions on how to effectively counter the negative narratives. In addition to qualitative research methods, it relies on a novel experi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Instabilities and homoclinic phenomena in Hamiltonian systems' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

A fundamental problem in the study of  dynamical systems is to ascertain whether the effect of a perturbation  on an integrable Hamiltonian system accumulates over time and leads to a large effect (instability) or it averages out (stability). Instabilities in nearly integrable systems, usually called Arnold diffusion, take place along resonances and by means of aframework of partially hyperbolic invariant objects and their homoclinic and heteroclinic connections.The goal of this project is to develop new techniques, relying on the role of invariant manifolds in the global dynamics, to prove the existence of physically relevant instabilities and homoclinic phenomena in several problems in celestial mechanics and Hamiltonian Partial Differential Equations.The N body problem models the interaction of N puntual masses under gravitational force. Astronomers have deeply analyzed the role of resonances in this model. Nevertheless, mathematical results showing instabilities along them are rather scarce. I plan to develop a new theory to analyze the transversal intersection between invariant manifolds along mean motion and secular resonances to prove the existence of Arnold diffusion. I will also apply this theory to construct oscillatory motions.Several Partial Differential Equations such as the nonlinear Schrdinger, the Klein-Gordon and the wave equations can be seen as infinite dimensional Hamiltonian systems. Using dynamical systems techniques and understanding the role of invariant manifolds in these Hamiltonian PDEs, I will study two type of solutions: transfer of energy solutions, namely solutions that push energy to arbitrarily high modes as time evolves by drifting along resonances; and breathers, spatially localized and periodic in time solutions, which in a proper set
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dynamic Signal Transduction in Individual Cells' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Regulation of proliferation and differentiation is a fundamental challenge for multicellular organisms. The decision between alternative cell fates is therefore tightly controlled by cellular signaling. During the past decades, the central components of the signaling machinery have been identified. The challenge we are facing now is to understand how signaling networks act dynamically in living cells and how they intersect with each other to control the physiological response of a cell. Since signaling networks contain complex, non-linear interactions that are difficult to understand intuitively, it will be important to use an interdisciplinary approach, combining quantitative experiments and theoretical analysis. As cellular decisions often vary even in genetically identical cells depending on the initial conditions and the micro-environment, we have to measure signaling on the level of individual cells.In the proposed project, we will investigate the TGFbeta pathway, a central growth-inhibitory pathway in epithelial cells. We will acquire quantitative data with high temporal and spatial resolution using time-lapse microscopy of live fluorescent reporter cells and combine it with mathematical modeling. Using this approach, we will determine how the structure of the network shapes its dynamic response, how activation of the signaling pathway is translated into changes in cellular physiology and how TGFbeta interacts with other networks to control cell fate. The resulting mechanistic understanding will enable us to manipulate cell decisions in-vivo and develop therapeutic interventions to regain control over aberrant signaling processes diseased cells.After a postdoc at Harvard Medical School, the applicant is moving back to Europe to start a career as an independent res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Neural Field Equations: Stochastic Approach and Numerical Simulations' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The aim of the present project is to provide the numerical modeling of neural processes, which can help to interpret the experimental data coming from EEG imaging. With this purpose we will use the Neural Field Equations (NFE), a widely used class of equations to model connected areas of neurons in the brain, in one to three dimensions. We  emphasize on employing stochastic variants of NFEs to describe neural activity. We intend to develop new numerical methods and use them to carry out numerical simulations of the processes under investigation. We will test the results of our simulations by comparing them with the ones obtained by other methods in neuroscience, in particular data driven methods. The project includes in its final phase a collaboration with a research team working with medical data.  The applicant, Pedro Lima  (www.math.ist.utl.pt/~plima), is a member of  the CEMAT (Center of Mathematics and Applications- www.cemat.ist.utl.pt),  a research unit of the Instituto Superior Técnico  (www.ist.utl.pt ), which is part of the Technical University of Lisbon (www.utl.pt). He  will visit for one year the Johannes Kepler Univesity  (JKU- www.jku.at ) at Linz, where he will work at the Institute of Stochastics  ( www.jku.at/stochastik) , under the direction of Prof. Evelyn Buckwar (the leader of the  Institute).The main  training objective of the applicant is the development of expertise in Stochastic Numerical Analysis,  Modelling with NFEs and Mathematical Neuroscience.   He will benefit from  the excellent experience of the research team of the Institute of Stochastics of the JKU,    which is renowned for its interdisciplinary strengths and track record on applied mathematical modeling. This project will have a very significant impact in the career of the applican
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Neural circuits for optimal prediction of timing' under Horizon 2020.

assistant: **Concept**

Predicting the timing of events is not only crucial to our survival but seamlessly contributes to everyday activities like riding bicycles, dancing or playing sports. Human and animal prediction of timing is statistically optimal, however, how such behavior arises from neural circuitry is poorly understood. Here I outline a theoretical framework, testable hypotheses and a set of experiments that will help uncover the neural circuits that integrate previous experience to make optimal estimates about the timing of events. In this proposal, the systematic investigation of optimality in complex forms of timing behavior is based on exploiting known neural circuits belonging to simple timing behavior. The anatomical origins of simple timing tasks like eyeblink conditioning are extremely well-characterized in the cerebellum of different species. Using this, I propose a framework for extending this circuit to understand optimal timing in a series of targeted physiology, behavior and optogenetics experiments. This research, if successful, will reveal the neural basis for how the nervous system combines previously encountered stimuli and recent observations to generate statistically optimal estimates and will generate valuable insights into the underpinnings of biological intelligence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'REvolutionary Approaches and Devices for Nucleic Acid Analysis' (READNA) under Seventh Framework.

assistant: **Objectives**

The REvolutionary Approaches and Devices for Nucleic Acid analysis – READNA – consortium is composed of researchers from 10 academic institutions, 5 SMEs and 3 large companies. The goals of the READNA consortium are to revolutionize nucleic acid analysis methods, by 1) improving elements necessary to use the currently emerging generation of nucleic acid sequencers in a meaningful and accessible way, 2) providing methods that allow in situ nucleic acid analysis and methods capable of selectively characterizing mutant DNA in a high background of wildtype DNA, 3) combining RNA and DNA analysis in a single analytical device, 4) providing technology to efficiently analyze DNA methylation (genome-wide, with high resolution and in its long-range context), 5) implementing novel concepts for high-throughput HLA-screening, 6) developing fully integrated solutions for mutational screening of small target regions (such as for screening newborns for cystic fibrosis mutations), 7) developing a device for screening multiple target regions with high accuracy, and 8) implementing strategies for effective and high-resolution genotyping of copy number variations.  An important part of READNA is dedicated to the development of the next generation of nucleic analysis devices on individual DNA molecules by stretching out nucleic acid molecules in nanosystems, using alpha-hemolysing nanopores and carbon nanotubes. These approaches will benefit from improved interrogation and detection strategies which we will develop. Our methods and devices will boost the possibilities of genetic research by closing in on the target of 1000 Euros for the sequence of a complete human genome, while at the same time leading a revolution in cost-effective, non-invasive early screening for diseases such as cancer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Accelerating Clinical Translation. Charting the Politics of Translation in the European Union' (ACTrans).

assistant: **Innovation**

In the post–genomic era, innovation policies in biomedicine are increasingly being driven by the notion that constant advancements in biological knowledge fail to materialize into tangible therapeutic outcomes. Discursively framed in terms of a “gap” between “bench” and “bedside” in need of urgent “bridging”, this representation of the shortcomings of biomedical innovation has propelled growing efforts tailored towards the clinical translation of research results. In the European Union, the acceleration of clinical translation has been positioned as a cornerstone of its innovation strategy, as attested by the launch of a host of translational policy initiatives and a vast array of regulatory reforms in the process of medicines approval.However, in spite of its growing relevance, the broader expectations, dynamics and implications of the translational enterprise at EU level have yet to be comprehensively drawn out by the social sciences. This project sets out to accomplish this objective. Drawing from qualitative research methodologies, it investigates the articulation of translational initiatives in the policy and regulatory context of the EU, with the aim to chart and analyze the different epistemic and normative expectations underpinning translational policies, the sociotechnical dynamics of their implementation, as well as their social and political implications. Specifically, the project focuses on the mobilization of translational initiatives into the service of EU socio–political consolidation and its transboundary exercise of political, economic and cultural power, and will investigate the possible tensions and trade–offs between the political ideal of competitiveness enshrined in such initiatives, and those of democratic accountability and social justice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Characterising plant interactions with bacteria that promote the uptake of nitrogen and sulphur from organic sources', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The plant rhizosphere contains an abundant and diverse array of microbes, and plants interact with this microbial community in diverse ways, from mutualistic to neutral to pathogenic . It is proposed that future agricultural systems should strategically incorporate mutualistic plant-microbe associations, whereby high-performing combinations of plant genotypes and microbial populations are co-cultivated to promote improved nutrient use efficiency and decreased fertiliser application . Currently, there is a poor scientific understanding of the precise biochemical transformations and exchanges that occur in mutualistic associations between plants and microbes, and it is also unclear which specific microbial species are the most effective for supporting plant growth and nutrition. There is evidence that plant genotypes exhibit differing capacities to shape their rhizospheric microbiome , but our poor mechanistic understanding of this phenomenon prevents breeding strategies to select crop varieties that will host favourable microbial interactions. Therefore, this project proposes to address these gaps in scientific knowledge, by undertaking co-cultivation experiments that investigate which specific bacterial species are most effective for enhancing plant uptake of nitrogen (N) and sulphur (S) from organic sources, as well as which specific Arabidopsis accessions are the most receptive hosts for these interactions. Next, isotope labelling and metabolic flux studies will be undertaken in the best and worst performing plant-microbe combinations, to define the specific biochemical routes of N & S transfer that are favourable for plant nutrition. Also, genetic investigations will be undertaken to find the key genes responsible for favourable plant-microbe interactions. This proje