RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'International Study for Treatment of Childhood Relapsed ALL 2020'.

assistant: **Objectives**

Relapse of acute lymphoblastic leukemia (ALL) remains a leading cause of mortality in childhood cancer. IntReALL 2020 will conduct randomized and historically controlled trials in children with relapsed B-cell precursor (BCP) ALL with the aim to replace toxic chemotherapy with better tolerated and more efficacious immunotherapeutic drugs. In standard risk (SR) patients, the CD22 directed antibody-drug conjugate inotuzumab ozogamicin (InO) will be randomly compared with standard of care (SOC) ALL-R3 induction. All patients will receive one SOC consolidation- and one Blina course, compared to historical controls. SR patients with MRD good response will receive 2 additional Blina courses replacing chemotherapy randomly compared with SOC. Patients with high-risk relapse will receive induction investigating InO versus ALL-R3 in an industry-sponsored trial, followed by IntReALL consolidation and allogeneic HSCT. Patients with isolated extramedullary (IEM) relapse are treated based on ALL-REZ BFM 2002 backbone. IntReALL 2020 will establish a federated relapsed/refractory leukaemia board generating personalized recommendations based on clinical, molecular-genetic and drug response profiling data. Patients with very-high risk disease will receive experimental/personalized  therapies, including a trial investigating CD19-directed chimeric receptor antigen (CAR) T-cells produced in academic institutions. Other CAR T-cells trials as well as an induction trial for T-ALL relapse will be developed. Documentation and monitoring of the trials and the individualized treatment will be realized using the MARVIN database. Comprehensive statistical and data management activities will warrant the accuracy and interpretability of the data. IntReALL 2020 involves representatives from participat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Methods for predictAble Design of heterogeNeous Embedded System with adaptivity and reliability Support' (MADNESS).

assistant: **Concept**

The MADNESS project aims at the definition of innovative system-level design methodologies for embedded systems, able to drive the optimal composition of an heterogeneous MPSoC architecture, according to the requirements and the features of a given target application field.<br/>The proposed methodologies will extend the classic concept of design space exploration, to cope with high heterogeneity, technology scaling, system reliability and multi-application demands, pursuing the following objectives:<br/>-Improve design predictability of highly heterogeneous embedded systems, bridging the so called implementation gap", i.e. the gap between the results that can be predicted during the system-level design phase and those eventually obtained after the on-silicon implementation.<br/>-Consider, apart from more traditional constraints (typically, cost, performance, power consumption), continued availability of service, taking into account fault recovery as one of the optimization factors to be satisfied.<br/>-Support adaptive runtime management of the architecture.<br/>The technical approach of the project will rely on the following methods:<br/>-In order to improve the design predictability, traditional system-level design methodologies will be extended to consider variables strictly related with physical implementation of the architecture, leveraging a specific layer for rapid and accurate on-hardware FPGA-based emulation.<br/>-In order to address fault tolerance and adaptive runtime resources management, new methodologies are going to be defined and included in system-level exploration. Specific hardware/middleware IP modules will be developed to pursue those objectives.<br/>The results of the project are expected to have a deep impact on the design flow for high-complexity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Chrome-teflon surface coating for process rollers' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

This project is concerned with fluoropolymer coated rollers and drying cylinders such as those used for the production of paper, paper products and textiles. Fluoropolymer coatings are essential in these industries due to their excellent non stick, low friction properties which allow the production rollers to operate at high speeds without creating friction or contamination of the final product due to sticking of production materials such as size and other additives. The aim of the project is to effect cost savings in the paper, paper products and textile industries through the development of an improved coating for production plant rollers. The project will develop an advanced roller coating with improved wear resistance to better withstand the aggressive treatment meted out in the production environment. This new coating material will be based on a composite material of fluoropolymer and chrome metal and is estimated to increase the lifetime of current fluoropolymer roller coatings tenfold from approximately 1 year to 10 years. The utilisation of this new technology in paper and textile plants across Europe will bring a number of economic benefits. The replacement of fluoropolymer roller coatings in situ will vastly improve the efficiency and reduce the production costs in these industries, where the replacement of roller coatings currently causes a hug amount of lost production time. The economic impact of the introduction of this new technology has been estimated at over 90MECU pre annum. Environmental and social benefits will also arise from the implementation of this new technology. There will be a reduced need for transportation of the rollers to and from a coating site and safety benefits will result from the reduction of the need to remove these large, often co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Novel Adaptive Cybersecurity Framework for the Internet-of-Vehicles' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

nIoVe aims to deploy a novel multi-layered interoperable cybersecurity solution for the Internet-of-Vehicles (IoV), with emphasis of the Connected and Autonomous Vehicles (CAVs) ecosystem by employing an advanced cybersecurity system enabling all relevant stakeholders and incident response teams to share cyber threat intelligence, synchronize and coordinate their cybersecurity strategies, response and recovery activities. To do so the project develops a set of in-vehicle and V2X data collectors that will feed nIoVe’s machine learning platform and tools for threat analysis and situational awareness across the IoV ecosystem. Advanced visual and data analytics are further enhanced and adapted to boost cyber-threat detection performance under complex attack scenarios, while IoV stakeholders are jointly engaged in incident response activities through trusted mechanisms. The proposed approach is supported by interoperable data exchange between existing and newly proposed cybersecurity tools. nIoVe solution will be demonstrated and validated in 3 pilots: Hybrid execution environment, simulated environment and real-world conditions. Overall, nIoVe ambitiously expects to  (i) reduce the attack surface of the overall IoV ecosystem, (ii) showcase effective and real-time detection of novel advanced threats and cyber-attacks in IoV ecosystems; (iii) reduce substantially the response time and reduce drastically the impact of breaches; (iv) contribute to the establishment and sustainable operation of Computer Security Incident Response Teams (CSIRTs) stimulating information and knowledge sharing across the IoV ecosystem; and (v) paves the way for the next generation robust, scalable and resilient IoV infrastructure. nIoVe draws and builds upon the accumulated experience from its conso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Functional analysis of Alternative Polyadenylation during neuronal differentiation at single cell resolution' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Understanding how stem cells differentiate into the myriad of cell types that compose an organism is a fundamental question in biomedical sciences. The recent development of single-cell transcriptomic techniques has already allowed the study of the cell composition of organs and tissues, developmental stages, and even whole adult organisms. Yet, in most cases, these studies are primarily descriptive and often provide little insight into the mechanisms regulating gene expression during cell differentiation. Here, I propose to study the role of alternative polyadenylation (APA) and associated RNA binding proteins (RBPs) in neuronal differentiation. For this purpose, I will: (i) develop new computational tools to detect and quantify APA events from single-cell transcriptomics data; and (ii) perform a single-cell-based functional CRISPR screen. The results obtained from this study will provide an in depth analysis of the changes in gene expression and APA during neuronal differentiation at a single cell resolution and identify dozens of APA targets specifically associated with individual RBPs. Together, this study will provide a solid molecular knowledge of the role of APA in neural differentiation, enabling the development of new personalized medicine therapies, which is in compliance with the Horizon H2020 Health demographic change and wellbeing programme.


**Keywords:** single cell transcriptomics, CRISPR screening, Alternative Polyadenylation, RNA binding proteins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'LPool - Rack-scale servers to Revolutionize AI Datacenters for Fast, Sustainable, Cost-efficient Computing' (Lpool).

assistant: **Innovation**

Over the past decade, the on-device performance of CPUs, GPUs, and AI accelerators has improved 100x faster than off-device data movement. This increasingly causes chips to wait for data, lengthening the time to run a job. This data bottleneck thus leads to massive inefficiencies, raising the cost, energy consumption, and carbon footprint to run AI jobs by 57% for datacenter providers and their end-users. ExpectedIT's solution consists of two new proprietary chips: the Large Pool CPU (LP-CPU) chip, its matching Pool chip, and accompanying novel server packaging technology. ExpectedIT will license the intellectual property (IP) for these innovations to chip and datacenter server vendors, enabling the best use of each device's precious off-device data movement. By removing the bottleneck, ExpectedIT's new solution allows AI or other data-intensive applications to run up to 10x faster. By completing the jobs in less time and using fewer hardware resources, LPool will offer datacenters and their end-users up to 2x reduction in costs, energy consumption, and carbon emissions to run a specific job. Our LPool technology will thus significantly impact AI's scalable and sustainable growth for diverse sectors like healthcare diagnostic AI, greentech, enterprise generative AI, and much more.We have validated our technology through over 100K simulation runs of the Verilog code. Based on these promising results, we have attracted the interest of one of the world's leading chip vendors with whom we are in active discussions for them to license the IP for our technology.This project will allow ExpectedIT to complete the engineering of the full chip logic for the Pool chip, the LP-CPU, and server packaging. It will also enable us to double our team size to 30 to carry out these activit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Atraumatic system for embryo recovery and transfer in sheep' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The use of embryo transfer (ET) can increase the rate of genetic development in ovine species. ET is also the most efficient method to move genetics over long distances and, properly managed, embryos are free of production diseases common to sheep. Embryo recovery and transfer in sheep require complete general aesthetic and full abdominal surgery or laparoscopes. So, the risks include other abdominal organs and stress. On the other hand, the success of an ET program will be reduced since these techniques impair the embryo viability. The objective of this project is to develop a non-surgical, Tran cervical technique to recover/pass embryos through the cervix into the uterus. The Tran cervical approach is very difficult in the ewe, because her cervix is small, very collagen us, with a tiny, tortuous path through it to the uterus.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Structural characterisation of the interaction between the small g-protein, rhoa, and its downstream effector rok kinase' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content Small G-proteins belonging to the ras superfamily acts as molecular switches, linking external signals to a wide range of basic biological functions. Among these, the members of the rho-family are involved in regulation of cytoskeletal formation, cell-cycle progression, cell proliferation and apoptosis. The molecular basis of the interaction between these proteins and their downstream partners does not parallel the vast amount of genetic and biochemical information available. The research objectives of this proposal are aimed to fill this gap, by determination of the structure of one of these small G-protein, rhoA, in complex with the rhoA binding domain of one its downstream targets, the ROK kinase. The work will involve the cloning of ROK constructs encompassing the rhoA binding domain, their expression and purification for biochemical and biophysical characterisation, crystallisation of the complex and the determination of the crystal structure. Training content (objective, benefit and expected impact) The kind of work to be done involves most of the advanced biochemical and biophysical techniques. It is expected that all these techniques will be usefully employed in Italy, in order to increase the human capital invested in structural biology, a field of life sciences largely neglected in the past, which is beginning to receive the attention it deserves.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Selection for antimicrobial resistance in a complex community context', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Increased antibiotic resistance (AMR) in a wide range of human pathogens is a growing public health threat, and the World Health Organization (WHO) forecasts a post-antibiotic era for the 21st century (WHO, 2014). The evolution of AMR in bacteria is determined by both the acquisition of resistance through horizontal gene transfer or chromosomal mutation and by the way resistance affects the competitive ability of a microbe in the presence and absence of antibiotics. The majority of research on selection for AMR to date has focused on detailed in vitro studies of selection for AMR in specific bacterial clones. More significantly, no studies to date have explicitly investigated the implication of being embedded in a complex community for the evolution of AMR. Therefore, in the proposed research I aim to use a multidisciplinary approach by for the first time combining the precision of in vitro experimental evolution experiments with the high resolution of molecular biology to study the evolution and spread of AMR in complex community contexts.The proposed project will allow me to complement my strong background in molecular biology and microbial ecology with evolutionary microbiology and novel bioinformatic approaches. Being situated in one of the most prominent microbial ecology and evolution laboratories worldwide, based at the Biosciences Department at the University of Exeter will be crucial for my personal development in becoming an independent European researcher. The University of Exeter provides an EU accredited program for academic training and personal career development.The proposed research will moreover provide ample opportunities to instigate and be involved in internal and international collaboration with world-leading researchers in diverse research fields.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'TagItSmart! - Smart Tags driven service platform for enabling ecosystems of connected objects' to be submitted under Horizon 2020.

assistant: **Abstract**

TagItSmart sets out to redefine the way we think of everyday mass-market objects not normally considered as part of an IoT ecosystem. These new smarter objects will dynamically change their status in response to a variety of factors and be seamlessly tracked during their lifecycle. This will change the way users-to-things interactions are viewed.Combining the power of functional inks with the pervasiveness of digital (e.g. QR-codes) and electronic (e.g. NFC tags) markers, zillions of objects will embed cheap sensing capabilities thus being able to capture new contextual information. Beside this, the ubiquitous presence of smartphones with their cameras and NFC readers will create the perfect bridge between everyday users and their objects. This will create a completely new flow of crowdsourced information, which extracted from the objects and enriched with user data, can be exploited by new services. TagItSmart will create an open, interoperable cloud-based platform with all the tools and enabling technologies, which will address the challenges related to the lifecycle management of new innovative services capitalizing on objects “sensorization”. TagItSmart will empower all steps involved from creating smart markers, Functional Codes (FCs), to supporting secure and reliable acquisition and consumption of such contextual data, while preserving user privacy, to the provision of generic functionalities and a service composition platform which will allow even inexperienced users to create and deploy their FCs based services while maintaining system efficiency.To boost the platform adoption, a set of industrial use cases will be used as a baseline for development, while additional stakeholders will be engaged through a co-creation Open Call approach. A carefully planned enga
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'FERTIliser product recovery from secondary raw materials using best available TEChniques' (FERTITEC), addressing dissemination and exploitation.

assistant: **Impact**

FERTITEC builds upon the knowledge gained from previous EU-funded projects, such as Novafert, FER-PLAY, MainstreamBIO, SOILUTIONS, SuMaNu, AgroTechnology ATLAS, B-FERST, NOVAFERT, CINURGI, Manure Standards, SUSFERT, NUTRI-KNOW, NUTRIMAN etc. which have explored the potential of waste management and nutrient recovery from various perspectives. By integrating the insights and technological advancements from these previous initiatives, FERTITEC is positioned to deliver a comprehensive solution for waste recycling and sustainable fertiliser production from secondary raw materials. The principal objectives of this group of related projects, that FERTITEC aligns with and supports, are to transform waste into high-quality fertilisers, promote a circular economy, and mitigate environmental impact, thereby aligning with the EU's goals of sustainable agriculture, waste reduction, and bioeconomy enhancement. FERTITEC is commited to develop competitive fertilisers that are not only benefit agricultural yield but also promote a circular economy model, aligning with the EU's strategic focus. This dual focus of environmental sustainability and economic viability resonates with the objectives of our previous projects, which aimed to boost the marketability of bio-based products and harmonise global sustainability certification systems respectively. By involving key actors from the agriculture sector and facilitating multi-stakeholder discussion through our KEP, FERTITEC fosters a community-driven approach to boost sustainable innovation in the fertiliser sector. We seek to make a tangible impact at national and regional levels, by deploying our best availalbe fertilising techniques in several EU countries, as well as extrapolationg our outcomes to the African Union landscape by providi