RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Implications of tissue stiffness in growth control during limb regeneration in salamanders (Ambystoma mexicanum)' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In several regenerating organisms it has been observed that distally amputated structures grow slower than proximally amputated ones, resulting in an overall time of regeneration that is independent of the tissue to be reformed. This observation suggests that cell proliferation or cell size could be adjusted with the plane of amputation along the proximo-distal (PD) axis, leading to an interesting scaling behaviour. It has been proposed that positional identity in the limb may be encoded as a proximal-to-distal gradient of cell surface molecules, that would in turn alter intercellular adhesions. Thus, it is possible that such differential adhesions are associated to the control of cell growth during regeneration. The central aim of this proposal is to address this question by combining cell biology, mathematical and physical tools, with the ultimate goal of understanding how the biomechanical properties of tissues affect regeneration, which may have important implications for the design of biomaterials aimed at being used for regenerative medicine.We will tackle this question in the highly regenerative salamander species Axolotl mexicanum, in which limb regeneration is initiated regardless of the amputation plane, and the regenerating limb grows until its size matches the contralateral undamaged one. We will evaluate growth rate and cell cycle of regenerating limbs amputated at different levels, and mathematically describe cell proliferation patterns. We will characterize several cell surface and extracellular matrix molecules along the PD axis, and measure tissue mechanics in vivo. Furthermore, we will for the first time, evaluate the Hippo pathway in salamanders, an important modulator of cell growth in response to several physical inputs, as the causal link between i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Stochastic Optimal Planning for Renewable energy sources Integration in power Systems' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Environmental concerns and the pursuit of sustainable energy sources have resulted in policy measures toward high shares of renewable generation. However, Renewable Energy Sources (RES), such as wind and photovoltaic power generation, are non-dispatchable, variable and uncertain. Traditionally, conventional generators provide balancing reserves. The increasing share of RES results in an increasing amount of required reserves, and hence it may have an opposite effect both from an environmental and economic point of view. The latter raises the need of cheaper and environmentally friendlier reserves providers. Demand response and storage resources could be utilized to offer ancillary services including reserve provision. However, these technologies include uncertainty, mainly introduced due to human behavior and weather conditions, rendering their successful exploitation challenging.Making optimal scheduling decisions in the presence of uncertainty is a challenging problem. The core in such mechanism to assess the trade-off between optimality and reliability. The SOPRIS project aims to address this problem by providing algorithms and tools for optimal decision making in power systems with uncertainty and provide performance guarantees for the system reliability.  Specifically, we propose using stochastic and optimization based techniques to address the problem of unit commitment, reserve provision and energy scheduling both on the generation and the demand side, while taking the network and reliability constraints into account. The SOPRIS project proposes additional corrective control schemes that exploit the controllability not only of the demand side but also of other network components that may not provide reserve capacity but their set-point can be modulated in a post-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Continuous health monitoring and non-destructive assessment of composites and composite repairs on surface transport applications' (COMPAIR).

assistant: **Innovation**

Composites are used in a wide range of applications in surface transport. Damage to composite components in vehicles and surface transport applications is not always visible to the naked eye and the extent of damage is best determined for structural components by suitable non-destructive and evaluation (NDT & E) techniques. A detailed NDT and/or health monitoring procedure for proper damage assessment needs to be performed. This involves identification of the nature of the damage, its position and its extent, during different phases of the material and/or structure, i.e. during manufacturing and assembly, as well as during maintenance and repair.   One can also locate damage by simply tapping the composite’s surface and listening to the sound (boundary between good and damaged composite can easily be mapped to identify the area for repair). Inspection for composite damage should be included in the regular maintenance schedules for composite structures. Nonetheless, particular attention should be made to areas that are more prone to damage by using continuous health monitoring approaches, as well as prompt and reliable NDT approaches.   Transient thermal NDT is a prompt and reliable approach and has the ability to provide quantitative information about hidden defects – features in composite materials and/or structures. Analysing the transient temperature in the time domain typically attains this. Furthermore, since most damage to fibre-reinforced composites is a result of low velocity and sometimes high-velocity impact, 3-D laser micro-topography could also be used for the surface morphology and analysis of the composites.  The SMEs and RTOs in this project are proposing to bring their expertise in composites assessment and/or NDT & E and in partnership with the LEs – Pu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'An environment for a virtual hypermedia factory'.

assistant: **Concept**

The main objective of the Virtual Hypermedia Factory (VHF) project is to demonstrate an advanced information production and dissemination environment for the electronic publishing industry. VHF aims to allow publishers to simplify the writing phase and publisher/author interaction, and also to bundle related documents in hypermedia form.VHF will be a network-based electronic publishing environment used to support publishers' technological needs and services in the areas of cultural heritage and tourism. VHF users will be able to start from an initial bundled package of electronic books, and buy or build their own electronic publication in which the content is customised to suit their own individual needs. The VHF demonstration environment addresses the needs of several specific domains, namely: - electronic publishing.- cultural heritage information dissemination. - electronic distribution of tourism information. Using such an electronic publishing environment, information publishers can simplify the authoring process to share products among different specialised markets, without duplicating their own multimedia input into individual publications. For publishers this means reduced effort in information production and dissemination, with consequent economic savings. As a first step a basic VHF environment will be experimented with using an ISDN network infrastructure for the delivery environment, and an ATM-based one for the production environment. It will be built upon a basic kernel of integrated tools for: - multimedia document publishing.- multimedia-based document browsing.- multimedia-based information retrieval. - security, accounting and trans-border publishing services. The various project partners each have specific objectives in the exploitation of the results
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Geometric Methods in Inverse Problems for Partial Differential Equations' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Inverse problems are a research field at the intersection of pure and applied mathematics. The goal in inverse problems is to recover information from indirect, incomplete or noisy observations. The problems arise in medical and seismic imaging where measurements made on the exterior of a body are used to deduce the properties of the inaccessible interior. We use mathematical methods ranging from microlocal analysis of partial differential equations and metric geometry to stochastics and computational methods to solve these problems.The focus of the project are the inverse problems for non-linear partial differential equations.  We attack these problems using a recent method that we developed originally for the geometric wave equation. This method uses the non-linear interaction of waves as a beneficial tool. Using it, we have been able to solve inverse problems for non-linear equations for which the corresponding problem for linear equations is still unsolved. We study the determination of a Lorentzian space-time from scattering measurements and the lens rigidity conjecture. We use geometric methods, originally developed for General Relativity, to analyze waves in a  moving medium and to develop methods for medical imaging. By applying Riemannian geometry and our results in invisibility cloaking, we study counterexamples for non-linear inverse problems and use transformation optics to construct scatterers with exotic properties.We also consider solution algorithms  that combine the techniques used to prove uniqueness results for inverse problems,  manifold learning and  operator recurrent networks. Applications include new virus imaging methods using electron microscopy and the imaging of brains. Practical algorithms based on the results of the research will be develop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Novel anodes for rechargeable lithium batteries' under Fourth Framework.

assistant: **Concept**

Research objectives and content The focus of this application is on novel oxide anodes for lithium batteries, which have recently been demonstrated to exhibit very large capacities. The work will involve both main group, especially tin, and transition metal oxides, paying particular attention to microstructure, nanostructure and the formation of amorphous structures. Various complex oxides, eg spinel MgSn204, ramsdellite Li2MgSnO8, which should tolerate a larger degree of Li-insertion will be investigated. Tin phosphates will also be synthesised and phase equilibrium relations in the Sn:P:B:O system investigated. Glassy systems in the lithia: phosphate: borate system will be targeted and the extent of SnO2 solubility in these systems investigated. PbO, Bi203 and Sb203 offer similar behaviour to SnOx, as do some transition metal oxide spinel systems. These will be investigated and attempts made to optimise potential and capacity by control of composition and nanostructure. Training content (objective, benefit and expected impact) The candidate already has an excellent background in applied electrochemistry, this project will allow him to develop his expertise in solid state chemistry and solid state electrochemistry. On completion of the Fellowship the candidate will have an excellent curriculum in these technologically important areas. This will not only greatly enhance his career prospects it will also be of benefit to the European economy. Links with industry / industrial relevance (22) The research group has strong links with companies involved in Lithium battery manufacture in Europe and with companies actively considering inward investment to set up a manufacturing capability in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Deciphering the role of astrocytes in chronic depression.' in the context of a Horizon 2020 call.

assistant: **Objectives**

Depression is a debilitating psychiatric disorder that affects 1 in 7 people worldwide. Despite coordinated efforts from researchers and clinicians alike, the neurobiological substrates of depression remain largely unknown. As a result, therapeutic options against depression are inadequate.Using a valid preclinical model, I recently demonstrated that depression alters the molecular composition of astrocytes and the organization of extracellular matrix (ECM), an assembly of molecules that are primarily synthesized and released by astrocytes. This results in disrupted information relay in the hippocampus and in cognitive impairment, both commonly seen in depressed patients. Thus, my work suggests a role of astrocytic (dys)function in the depressive state. In the proposed project, I aim to unravel the contribution of astrocytes in the pathophysiology of depression. First, I will address how the depressive state affects astrocyte proteome, morphology and function. Second, I will address the role of astrocytes and astrocyte-derived ECM in the manifestation of depression at the molecular, cellular and the behavioural level. To reach my goals, I will make use of genetically engineered mice that allow for visualization, metabolic labeling and targeting of astrocytes. These mice will be subjected to social defeat to induce a chronic depressive state. I will study astrocyte morphology, physiology and proteome alterations in depressed mice vs. controls. After establishing astrocyte-specific changes, I will employ i) viral vector-assisted silencing of the expression of astrocytic genes contributing to the ECM and ii) designer receptor exclusively activated by designer drugs (DREADDs)-assisted modulation of astrocyte activity. I will then assess whether these interventions can ameli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European clinical study for the application of regenerative heart valves' to be submitted under Seventh Framework.

assistant: **Abstract**

Acquired and congenital heart disease can necessitate heart valve replacement. However, current heart valve substitutes are not considered ideal as they need anticoagulation, bearing the risk of bleeding when manufactured from non-organic material, or they degenerate when they derive from animals or human tissue donators (homografts) thereby leading to frequent reoperation especially in the young population. An ideal heart valve substitute would overcome these limitations and even have the potential to grow when implanted in pediatric patients.Haverich et al. have developed an implant for heart valves, which is better tolerated than the known alternatives and which has the potential for regeneration by autologous recellularization. Implants derive from donated homografts, which are chemically treated to inactivate potential microorganisms and viruses. The heart valves then are decellularized chemically, so that only connective tissue remains, the matrix of the decellularized heart valve (DHV). DHV has been examined in extensive animal studies, including immunological and toxicological analysis, long term and growth models, all of which have shown that the implant is well tolerated and spontaneously recellularized by the recipient.The proposed ESPOIR project is based on auspicious early clinical results in 45 children and young adults. In order to drive translation of this promising regenerative approach towards practical clinical use and to reduce the burden of congenital heart defects in particular, the ESPOIR consortium will undertake a prospective multi-centre trial to include at least 200 patients from 8 leading European Centres for Congenital Heart Surgery, for robust statistical evaluation of DHV in direct comparison to conventional heart valve substitutes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European Doctoral programme on ENergy and Environment' (EDENE) under Horizon 2020.

assistant: **Objectives**

The European Doctoral Programme in Energy and Environment (EDENE) is a multidisciplinary, intersectoral and international ambitious project over a 5 years duration offering a quality training to 30 international and highly skilled PhD Fellows in the field of Energy and Environment.Since the University of Pau and Pays de l’Adour (UPPA) obtained in 2017 the excellent label I-site (competitive Initiative Science/Innovation/Territories/Economy by the French Programme Investments for the Future) for its project Energy & Environment Solutions (E2S), UPPA’s priority is to develop international collaborations with targeted universities, to attract new talents, and to develop the international courses offer, mainly in Energy and Environment areas. Using its comparative plus points in terms of location (Pyrenean cross-border France/Spain region), UPPA developed cross-border collaborations and sound partnerships with international companies located in the south west region of France. EDENE was born from these collaborations and gathers leading expertise from a strong consortium: two universities (UPPA, University of Zaragoza), international companies (TOTAL, Enedis, Bertin, Teréga) competitive clusters (POLE AVENIA) and Technology Transfer Office (Aquitaine Science Transfert - AST).EDENE intends to address two major European Societal Challenges SC3 “Secure, clean and efficient energy” and SC5 “Climate action, environment, resource efficiency and raw materials”, by enabling promising Early Stage Researchers to achieve excellent research applied to energy and environment areas in mathematics, engineering, geosciences, aquatic environments, computer sciences, land development, treatment of economic data, or physical-chemistry.


**Keywords:** Energy, Environment, Mathematics, Enginee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'PHEromones for Row crop Applications' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Agricultural productivity needs to rise by 70% by 2050 to provide sufficient food for the growing population on a limited amount of land and water, while climate change and the onset of insect resistance makes pest control increasingly difficult. The current (overused) tools, chemical insecticides and GMO-crops, are not sustainable and most of the alternative biological solutions are not feasible for the large scale agriculture in row crops due to the high cost, complicated application methods, and inconsistent performance. Mating Disruption (MD) is an effective, affordable, and sustainable pest control method, which uses insect sex pheromones to prevent pest reproduction by disrupting their ability to attract mating partners. Mating Disruption is a scalable new solution for row crops, with 20-years of successful application in specialty crops. MD is a sustainable, non-toxic pest control method, which does not affect biodiversity, soil, or groundwater.The key objectives of PHERA are to demonstrate cost-efficient production of three bio-based pheromones at full industrial scale and to demonstrate pheromone effectiveness for pest control and for sustainable increase of agricultural productivity in the field. The cost of pheromones has been a key barrier to the wide adoption of MD in row crops. Biological production of radically cheaper pheromones is a disruptive technology that will allow the application of pheromones for pest control in row crops. PHERA will create a new value chain across biotech and ag-tech, and the consortium brings together all required expertise in biotech production and pheromone formulation and application. PHERA will create a new ag-tech business for MD solutions in row crop applications worth €640 million and 300 new jobs by 2027, and a long-ter