RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Research and development of a new concept of mass production low tension connectors with new self stripping and permanent high compression technology' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The main goal of this prcgect is to create new products in the field of low tension connections wi th self stripping technology for mass use and study and test of material in insulating technology (rubber, polycarbonats, PVC, thermo hardeners and thermoplastics) and using permanent high compression technology only used actually for telecommunications The aim of the research prqect is to develop moulds and prototypes of this new product and test it for its best economical and technical definition and then, try to specify the necessary machine for, after the research, manufacture this equipment and process lines to be able to develop a future industrialization first on a professionnal market and then for the general Public The interest of such a research is to create a new product replacing old technologies with screws, crimp connections or brazing for security, ergonornic, insularion, reliability and performance purposes The SME proposers - manufacturers of electronic and electrical components and producing equipments for energy (piles, batteries) and of of automatismand electronic tools - would be interested to contribute to this project and work with RTDs dedicated to research on insulating materials, study and specifications of the prototype, performing tests of this prototype, and study of the specifications of manufacturing equipment and process line
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'SEIMED services to enhance innovation management capacity of SME's  KAM services' to be submitted under Horizon 2020.

assistant: **Abstract**

Innovation support by the Enterprise Europe Network - SEIMED to enhance the innovation management capacity of SMEs & services as key account managers for the SME Instrument beneficiaries in the regions of Comunidad Valenciana y Murcia. In order to enhance SME innovation management capacity, we will support SME´s to implement truly effective processes in order to become more competitive and have a pro-active attitude towards the changing business environment. The traditional approach to innovation is insufficient to make a qualitative leap in competitiveness and facilitate the renewal of the company. Our purpose within this programme is to accompany the enterprise in the process of diagnostic audit, definition of an action plan and the implementation of an innovation management system. It is necessary to create a system that could continuously generate innovation and not only erratic and sporadic progress. This service will be implemented as comprehensive seven-day service packages following the processes and guidelines that are laid down for this purpose. It will be delivered by suitably qualified senior innovation experts and be linked to the other support services of the Enterprise Europe Network SEIMED.


**Keywords:** SME Instrument, coach, innovation assessment, gaps, choaching plan, diagnostic audit, innovation management system, IMP3rove, innovation strategy, culture and creativity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LYMPHIT: an innovative easy-to-use and cost-efficient diagnostic microneedle patch for the early detection of Lymphedema' (Lymphit).

assistant: **Concept**

Lymphedema is a chronic condition, outlined by a progressive accumulation of fluids in a limb, leading to great physical and psychological debilitation of the affected patient and often occurring secondary to oncologic treatments. There is not early diagnosis for lymphedema. Current diagnostic methods are highly inadequate and detect the disease only at an advanced stage, leading to serious complications, greatly decreasing quality-of-life of the patients while increasing healthcare costs. In response to this challenge, Dicronis has developed a diagnostic tool (LYMPHIT) based on a painless and minimally-invasive delivery of ICG, an FDA approved fluorescent agent, with an extremely high safety profile, integrated into polymeric dissolving microneedles patches which allows determining the status of the lymphatic system by optically measurement of the fluorescence decay. LYMPHIT enables patients and clinicians the earliest possible detection of lymphedema, by quantitatively tracking the function of the lymphatic system in a painless, easy-to-use and highly-scalable manner. LYMPHIT will be disrupting in the market by empowering medical practitioners to timely and selectively prescribe conservative treatments, which can contain or avoid a worsening of the swelling in the affected limb. Therefore, LYMPHIT will reduce lymphedema treatments costs up to 50% and reduce 10-fold the social costs associated to productivity loss, both of them associated with late stage lymphedema. Upon completion of the project, LYMPHIT will boost the growth of our company generating additional 64 FTEs, revenues of €398M and a ROI of 10.25 by the fifth year after Phase 2 execution. With the help of the SME instrument, Dicronis aims to complete the product optimization and clinical validation so that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Supersymmetry, supergravity and geometry in particle physics and string theory' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The Standard Model of particle physics, which has so far provided a successful description of elementary particles, is believed to be an incomplete theory. New experiments are starting to probe physics beyond the Standard Model. Supersymmetry, supergravity, and string theory are the theoretical tools that are expected to describe the new physics proposing solutions to fundamental problems such as the nature of dark matter, the unification of forces and the formulation of quantum gravity. Moreover, a symbiotic relation between string theory and mathematics has proven to be central for both fields. The present project aims at a deeper understanding of challenging features of supersymmetry, supergravity and string theories in the intersection of physics and mathematics. The applicant has recently developed a projective superspace approach to off-shell matter-coupled supergravity with eight supercharges in four- and five-dimensions. The main line of research we are proposing will focus on the application and extension of this approach. As a major application we will construct new quaternionic-Kahler geometries. The new techniques will be used to achieve a better understanding of 4D effective-actions in compactified string theory. Superspace approaches to supergravity theories are also relevant in studying extra-dimensional phenomenological scenarios in dimensions less than six. A second goal of the project concerns the study of 2D supersymmetric sigma-models having generalized complex manifolds as target spaces. Generalized complex geometry naturally arises in string theory and a better knowledge of the underlying mathematics will lead to powerful tools for the physicists. Using superspace techniques we will study the topological sectors of these theories that could give ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project '13MW CHP plant based on biomass Gasifier with gas engines' (BGGE).

assistant: **Concept**

The partners will demonstrate and optimize a novel CHP plant based on biomass gasification on a full scale (13 MW thermal input). In this plant two biogas fueled engines produce electricity (4 MWe) from gasified biomass. While the district heat (8 MWth) is produced in various heat exchangers.The BGGE CHP plant will be built at an existing CHP plant in Lemvig, Denmark. Since this is the first time that some of the main plant components will be built and integrated on this scale important aims of this project will be the process optimization and demonstration of the integration. The ultimate goal is to make this technology competitive with the power plants based on fossil fuel.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Temporal coordination of gene expression during development' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

During embryonic development cells coordinate spatiotemporal patterns of gene expression. A prominent example of this coordination is found in the gastrulation of amniotes, where Brachyury (Bra), a transcription factor, is synchronously and transiently expressed in a localized population, the Primitive Streak (PS). Even though the current view is that a morphogen gradient drives the spatial arrangement of Bra expression, the precise mechanisms controlling timing and coordination of cells remain to be elucidated. Recent evidence of the existence of RNA polymerase II (Pol II) pausing control in the bra locus in differentiating mammalian cells prompts the question of whether this mechanism is involved in the coordination of Bra expression. In Drosophila, Pol II pausing has been associated with developmental control genes, where it has been suggested to enhance the synchrony of expression in response to stimuli, and consequently increasing cell coordination during morphogenesis. Despite Pol II pausing is pervasive in mammalian embryonic stem cells (ESCs), its role in the fast and coordinated activation of gene expression has non been addressed yet.Here I propose to study how coordination of Bra expression is attained in differentiating mouse ESCs, which are known to recapitulate the cellular and molecular events observed in the PS. I will combine live cell imaging with theoretical modelling, to investigate the temporal dynamics of Bra activation. I surmise that Pol II pausing modulates stochasticity in the response and thus affects cellular coordination in Bra expression. To test this hypothesis, I will modify the levels of pausing in the bra promoter and correlate them with achieved cellular coordination.The results of this project will deepen our insight in the mechanisms
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European mouse mutant archive' (1994-1998).

assistant: **Innovation**

1. Objectives The past decade has seen the development of new technologies which allow the precise manipulation of the mammalian genome. These procedures mean that it is now possible to mutate any mouse gene to either a null or a conditional allele, in all cells of the organism or only in selected cells, and to transmit such mutations through the germline exactly as if they were classical, spontaneously arising mutations. The extraordinarily rapid progress of the human genome project means that all genes will be identified shortly and that the major issue for the future will be study of the biological functions of these genes. The creation of mutant mice is the only presently practicable way of doing this It is already abundantly clear that such mutant mice are of enormous value both for the understanding of basic biological processes and for the creation of models of human diseases that are the major threats to the health of European societies and the major targets for European pharmaceutical industries Many laboratories are now capable of applying this technology, in the development of which Europe played a major role, and some of them are operating on quite a large scale. However, it is proving to be impossible, for even the largest and best funded research institutes, to retain all of these animals once the purpose for which they were originally made has been achieved. It is essential that all mutants that are created are retained and help in a central repository from which they many valuable mutant animals will be destroyed because of the constraints of space and finance that affect the individual laboratories. The value of such central repositories has been well established by the contributions made by these that maintain collections of the genetically tractable o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Benchmarking complex event processing systems' to be submitted under Sixth Framework.

assistant: **Abstract**

Many IT systems consist of several distributed pieces of software processing thousands of events (or messages) per second. Complex Event Processing (CEP) is a new area at the intersection of relational databases and data stream systems that promises to discover, in near-real time, relevant information hidden in the million of events processed by IT systems.As an example, a CEO of one CEP company described an application that, using RFID technology, detects and locates missing children in amusement parks even before the parents notify the child is missing. A number of companies in the US have just made available their first CEP products.However, the products were developed by people from different backgrounds: arbitrage companies, query language researchers, data stream developers, and database vendors. The different backgrounds and the rush to beat the competition lead to a fragmented market: essentially every CEP product has a different query language, semantics, feature set, and performance concerns. This market fragmentation is not just unfortunate; it also stifles research.The CEP field looks today as the database field looked 30 years ago: competing data models and lack of standards and benchmarks. In databases, SQL and the relational model were eventually accepted, benchmarks proposed and a common ground was found. Scientists proposed new algorithms, which could then be applied to a large product base and the database field exploded into a multi-billion dollar market with first-class research ideas yea r after year.This is a great time for Europe to step into this new field, and lead it. In that direction, we propose an important first step: Benchmarks for CEP systems (BiCEPs). BiCEPs can help unify the CEP market, can help the discovery of the fundamental scienti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Application of novel cyclic ligation auxiliaries in the study of Transthyretin and derived pathologies' (CycLATTR).

assistant: **Concept**

The area of influence of proteins comprise most biochemical reactions and recognition process that govern a living body. However, its malfunction often lead to devastating diseases, like the ones related to Transthyretin:famylial amyloid polyneuropathy (FAP), famylial amyloid cardiomyopathy (FAC) and systemic senyl amyloidosis (SSA), cureless to date. Chemical approaches to some of these biomacromolecules have been possible after the discovery of the native chemical ligation, which involves assembly of unprotected Cys-peptide and peptidyl-thioester fragments in aqueous environments. Nonetheless, this technique still encompasses major limitations that has prevented its application to virtually all proteins, such as the requirement of N-terminal Cys peptides and low yield in bulky ligation sites. To increase the scope of ligation, thiol-containing building blocks and thiol-directing ligation auxiliaries have been designed, which allow ligation at non-cysteine ligation sites, but are either sequence dependent or lack sufficient efficiency.In this proposal, we aim to introduce new families of ligation auxiliaries that overcome the classical restrictions of this technique and improve previous strategies. In more detail, two complementary templates will be investigated: mercapto-cyclopentadienil and mercapto-cyclopropylethyl. The former structure is specifically designed to enhance the ligation rate by placing the thiol group in an ideal position with respect to the nitrogen, whereas the latter decreases the sterical hindrance and enhances the acid lability of the auxiliary. To practically illustrate the applicability of this new methodology, the native sequence and mutated analogues of Transthyretin at critical positions will be chemically achieved, a major milestone in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Automated Maskless Laser Lithography Platform for First Time Right Mixed Scale Patterning' (OPTIMAL), addressing dissemination and exploitation.

assistant: **Impact**

Laser-based technologies for creating structures in the range from nanometer up to millimeter size find many applications such as free form optics, photonics, multifunctional surfaces, lab-on-chip, etc. with a global market volume of > 200 billion euros. The original structures know as masters are the first step in the making of tools for key-enabling technologies like injection molding or nanoimprinting. Some of the current limitations in the laser lithography processes are the limited depth of the structures, small area and low speed at process level, high-power consumption in the laser interference lithography, and multiple and expensive processes required for the development of hierarchical multifunctional structures at industrial level.The OPTIMAL project will integrate for the first-time different laser lithography technologies, quality monitoring systems and processes in one platform for the development of structures with (i) high depth (150 micrometer), ii) dimensions in the range from 100 nm to sub-mm in XYZ, iii) 2D&3D shape on flat surface, (iv) combining parallel & serial patterning, (v) no need for external treatments on samples; vi) increased speed (1 cm2/min) and large area (up to 2000 cm2), vii) > 40% of reduction in the consumption of resources for the whole manufacturing process. The OPTIMAL project uses self-learning algorithms to optimize the virtual photomask as well as integrates methods for an inline control of the laser patterning. By accelerating and upscaling the structuring process, the OPTIMAL project will increase the process efficiency and yield, which will reduce the energy consumption, avoid material waste, decrease costs, and lead time in many applications. The platform will potentiate the possibilities in the sustainable making of high
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Towards understanding non-canonical phosphatidylinositol kinases in the maintenance of prostate metabolism.' (PCAPIP).

assistant: **Innovation**

As a result of it’s specialized secretory functions, the prostate has a unique biology that makes it prone to the development of cancer. Specifically, a strong dependence on hormonal stimulation through the androgen receptor (AR) pathway that is implicated in driving downstream changes to the central metabolism of the cell. To find answers to clinical questions, I am delving into the fundamental mechanisms of a previously overlooked family of lipid kinases. The type II phosphatidylinositol-5-phosphate 4-kinases (PI5P4Ks) are responsible for regulating a proportion of phospholipid species found embedded in the membranes of various cellular organelles. Intricate differences of the composition of these membranes can have a major effect on the regulation of cell cycle, metabolite trafficking, growth and survival. Herein, I outline a basic examination of the PI5P4Ks that will establish the first understanding of their phenotypic importance in prostate cells. There is reason to believe that these enzymes are critical regulators of the AR pathway that may be a trafficking conduit for changes to AR regulated metabolites. To test this, I am generating the first prostate-specific PI5P4K knock-out mouse model. A state-of-the-art metabolomic evaluation of both this animal model and a collection of human cell models will uncover the ultimate relevance of the PI5P4Ks in prostate biology. The proposed study will provide valuable insights into a non-canonical family of kinases that could lay the groundwork their development as novel drug targets.