RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'ORGanic UPconversion device for SWIR imaging'.

assistant: **Innovation**

Short-wave infrared (SWIR) imaging is a powerful tool to access and visualize the composition of (bio-)materials contact-free and in real time. It can be used for example for in-vivo deep-tissue bio-imaging as well as for the inspection and quality assurance of manufacturing processes, including agriculture, pharmaceutics, chemicals, photovoltaics, wafers, metals and glasses. The global SWIR market is estimated to 213 million USD for 2022 and predicted to increase by 72% until 2028. However, the complex and costly manufacturing of commercial SWIR imaging prohibits consumers and low-end applications from benefiting from its vast application potential. Within ORGUP, we propose organic upconversion devices as an attractive low-cost alternative. They convert the invisible, infrared image into a visible image, being then captured by a low-cost commercial camera or sensor. However, so far, such devices have failed to provide the relevant SWIR sensitivity above 1100nm, i.e. the silicon cut-off. The goal of ORGUP is to develop and showcase for the first time high-quality, organic SWIR imaging with a sensitivity up to 1500nm and an upconversion yield of 30% - at a low cost, while avoiding the use of toxic elements. Two industrially relevant demonstrators will prove reliable and durable mono- and multispectral vision at high resolution and contrast. We will combine in-house, recently developed ultra-low gap organic semiconductors with unique know-how in organic near-infrared opto-electronics and stacked, state-of-the-art organic light emitting diodes. Selectivity for specific SWIR wavelengths will be achieved by embedding the organic stack into optically amplifying and spectrally selective microcavity structures. As research and development of the proposed type of organic upconve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'TOwards imProved screening for breast, cervical and colorectal cancer in Eastern-Europe: Equitable, Actionable, Sustainable and Trustworthy' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Colorectal, breast and cervical cancer cause 155,000 deaths each year in middle income countries (MIC) in Eastern Europe, while there is good evidence that a large proportion could be prevented by organized screening. Although many MIC in Eastern Europe have implemented some form of cancer screening, this screening is often non-organized, leading to lack of data and quality assurance systems. Also, coverage is commonly low and minority groups are not reached. In a previous HORIZON2020 project ‘EU-TOPIA’, we developed road maps to improve cancer screening programmes in Europe. In the current project, EU-TOPIA-EAST, these roadmaps will be refined and translated into action plans for three MICs: Georgia (breast), Romania (cervix) and Montenegro (colorectal). These action plans will take the local health and social system into account by performing detailed barrier and stakeholder analyses, leading to feasible changes to current screening programs. Next, we will implement these action plans: e.g. in Georgia, we will increase coverage of the programme by establishing a new screening unit; in Romania, we will develop new IT infrastructure to allow invitation-based cervical cancer screening; and finally in Montenegro we will establish a new colonoscopy center to increase programme capacity decrease travel time for participants. The implemented programs will be monitored and evaluated using key indicators and sophisticated decision models to predict the long-term and country-wide benefits, harms and cost-effectiveness. During workshops and roundtable discussions for policymakers and screening program coordinators from all countries in Eastern Europe and the Mediterranean to build capacity and upscale the implementation of these intervention(s) in Equitable, Accessible, and SusT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Investigation of ceramic membranes for ozone/oxygen separation' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Ozone is one of the strongest oxidising media. It is used a.o. for contaminant-oxidation inindustrial and local drinking and waste water treatment (ground water and drinking water purification, leachate treatment, industrial waste water treatment, process water recycling), for waste gas or exhaust air treatment and for bleaching in the pulp-, paper- and textile industry. Ozone is by the factor 1,5 more effective than the predominantly used oxidant chlorine. Ozone which is decomposed to oxygen does not produce any contaminating substances whereas chlorine produces salt contents and partly also chlorinated hydrocarbons in the oxidised media. The major obstacle for a significantly larger spreading of ozone technology are the high ozone production costs. On the one hand high energy is used to produce comparatively low quantities of ozone and on the other hand a large amount of initial high-purity oxygen is needed of which only a small fraction (3-13 weight-%) can be converted to ozone. The objective of this project is to reduce the energy required to produce an ozone-gasstream with a high ozone concentration and simultaneously reduce the oxygen consumption. The ozone containing gas will be produced from oxygen at the energy optimal operating point of the ozonizer by the conventional way of silent electrical discharge. The ozone portion will then be separated and upgraded by ceramic gas membranes and the not converted oxygen will be recirculated to the ozonizer. Because Europe is world's leader in the production of ozonizers (about 75%) and the consumption of ozone (about 50%) it is the paramount interest of the European producers and users of ozone technology to further develop the performance of modern ozonizers, i.e. the economic efficiency of the production of high conce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards microRNA modulators by fragment-based drug discovery (FBDD) approaches' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

MicroRNAs have been identified as important endogenous regulators of gene function. Aberrant regulation of them has been linked to various human diseases. Small molecule intervention has the potential to provide a new therapeutic strategy. The aim of the project is the identification of selective microRNA modulators by fragment-based drug discovery (FBDD) approaches.MicroRNAs are short ribonucleic acid (RNA) molecules, on average only 22 nucleotides long that act as post-transcriptional regulators by binding to complementary sequences in the three prime untranslated regions (3`UTRs) of target messenger RNA transcripts (mRNAs), usually resulting in efficient sequence-specific gene silencing, which is referred to as RNA interference (RNAi). The numerous reports indicating a role of microRNAs in connection with diseases such as diabetes, neurological disorders, and cancer  raises the question whether microRNA could be targeted in the development of a novel therapeutic strategy.Fragment-based drug discovery (FBDD) methods have been developed for finding lead compounds as part of the drug discovery process. The approach is based on identifying small molecules (with a molecular weight less than 250 Da and so called fragments), which generally bind only weakly to the biological target, and then iteratively elaborating them to produce successively more potent compounds.The target microRNA will be microRNA-122, which plays a key role in hepatitis C virus infection, microRNA-155, an inducer of pancreatic cancer by suppressing the expression of cell-cycle protein p53 and let-7 microRNA, which has been shown to control the timing of development of nematode Caenorhabditis elegans from the last larval stage to adulthood.Detailed binding studies will be done by NMR spectroscopy. In co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'EEN Anatolia supports to increase the innovation management capacities of SMEs' (EENinnoSMES4) under Horizon 2020.

assistant: **Objectives**

The proposed project addresses the action for “Establishing services “Enhancing the innovation management capacity of SMEs” in the Enterprise Europe Network” to improve the innovation management capacity of SMEs. In the period covering the years 2015-2021, Tier 1 and Tier 2 services were offered to SMEs by EEN Anatolia Consortium. (The contents of Tier 1 and Tier 2 were respectively generic promotion, networking services given by EEN staff and specialized advisory services given by innovation advisers). The activities foreseen under this proposal is to give Tier 3 services to SMEs.106 full enhancing SMEs’ innovation management capacity service packages and 20 Key Account Management service packages will be offered to SME’s till the end of 2021 and every service package is foreseen. Partner 06 of EEN Anatolia Consortium, has undergone changes in the structure and staff of the organization and will be inactive in 2020-2021.


**Keywords:** Innovation management, Key Account Management, Improve assessment,  SME Instrument, Fast Track Innovation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Guidelines for interoperability in networks and atm deployment' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The primary objective of GINA is to harmonise, enhance and disseminate guidelines about Network Evolution, Network Interoperability and ATM deployment, reflecting the latest findings and results of trials within ACTS (which will be run on a chain-basis" by projects in the Network Interoperability Chain Group) but also reflecting the findings about the world-wide evolutionary trends in Network Interoperability and the development and deployment of ATM.Guidelines are needed by users (residential users as well as small, medium and large enterprises), by telecom and computer vendors, by PNOs and service providers, by telecom/IT SMEs, but also and equally important by regulators, social and legal advisors, by the Parliament, the Council and other politicians.The second objective of GINA is to provide logistic and administrative support, co-ordination and assistance in the concertation process within the Network Interoperability Chains and Chain Group, in order to achieve high quality during the production of guidelines.The third objective of GINA is to document the guidelines in a structured, comprehensible, up-to-date, frequently reviewed and upgraded form in simple wording, free of jargon and intricate technical terminology, and supported where necessary, by short but basic clarification of the telecom/IT technology to a non-technical audience.In the world of telecommunications, the right information at the right time is the most important issue for decision making at both the strategic and research levels. GINA provides timely and accurate information in the form of "guidelines", collated from the results of ACTS projects, (refined through the concertation mechanism of chains), Standardisation Bodies, research activities world-wide and public information available from sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Role of Granzymes A, B and M in Sepsis' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Sepsis, the systemic inflammatory host response to infection, is a major health problem. Inflammation is considered the first line of defence in host-pathogen interactions. Granzymes (grzs) are a family of proteases released from secretory granules that have been suggested to have relevant effects in inflammation. Outstanding findings are the rationale to hypothesize that granzymes play an essential role in the host response to bacterial sepsis: various bacteria can induce release of GrzA and B by leukocytes; elevated plasma levels of GrzA and B have been found in patients with sepsis; intravenous injection of LPS into healthy humans is a potent inducer of GrzA and B; deficient mice in GrzA and M are resistant to LPS-induced systemic inflammation and lethality; and GrzA-deficient mice show an improved host defence during pneumonia caused by S. pneumoniae.The aim of the proposed project is to determine the role of GrzA, B and M in host response to bacterial sepsis, studying which cells produce them and via which receptors this production is induced, and what their function is during sepsis. For this purpose, we will use mouse models of sepsis, pneumonia and peritonitis (the most common causes of sepsis) and human subjects from the Intensive Care Unit with and without sepsis and healthy controls. We will determine grzs producing cell types and grzs plasma levels both in humans and mice. We will examine the role of Toll-like receptors (TLR) in the bacterial induction of grzs in splenocytes from TLR-deficient mice incubated with relevant bacteria, and then compare grzs expression of wild-type and TLR-deficient mice with sepsis. Finally, grz-deficient mice will be compared with normal wild-type mice with regard to key host responses during pneumonia, peritonitis or primary s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Molecular mechanisms of mature B cell lymphomagenesis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Most of the lymphomas diagnosed in the western world are originated from mature B cells. The hallmark of these malignancies is the presence of recurrent chromosome translocations that usually involve the immunoglobulin loci and a proto-oncogene. As a result of the translocation event the proto-oncogene becomes deregulated under the influence of immunoglobulin cis sequences thus playing an important role in the etiology of the disease. Upon antigen encounter mature B cells engage in the germinal center reaction, a complex differentiation program of critical importance to the development of the secondary immune response. The germinal center reaction entails the somatic remodelling of immunoglobulin genes by the somatic hypermutation and class switch recombination reactions, both of which are triggered by Activation Induced Deaminase (AID). We have previously shown that AID also initiates lymphoma-associated c-myc/IgH chromosome translocations. In addition, the germinal center reaction involves a fine-tuned balance between intense B cell proliferation and program cell death. This environment seems to render B cells particularly vulnerable to malignant transformation. We aim at studying the molecular events responsible for B cell susceptibility to lymphomagenesis from two perspectives. First, we will address the role of AID in the generation of lymphomagenic lesions in the context of AID specificity and transcriptional activation. Second, we will approach the regulatory function of microRNAs of AID-dependent, germinal center events. The proposal aims at the molecular understanding of a process that lies in the interface of immune regulation and oncogenic transformation and therefore the results will have profound implications both to basic and clinical understanding of lymp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Function of small RNAs across kingdoms' under Sixth Framework.

assistant: **Concept**

In December 2002,Science magazine selected small Ranks with regulatory function as the scientific breakthrough of the year. Small Ranks play a hitherto unrecognized critical regulatory role in controlling gene expression at different levels in a variety of organisms across kingdoms. The number of small non-coding RNAs discovered in recent years is in a range of one thousand. In a fundamental genomics approach this consortium aims to-wards advancement of knowledge on how regulatory RNAs are integrated into the general network of gene expression. Evolutionary aspects will be addressed to obtain a broad and integrated understanding of riboregulators. Thus, organisms from different kingdoms (eubacteria, protists, plants and animals) will be investigated, along with various classes of regulatory RNAs (microRNAs, snoRNAs, bacterial small RNAs). Molecular targets will be identified and characterised and the expression patterns of target and regulatory RNA monitored under various environmental or developmental conditions. We will develop bioinformatic tools by designing new algorithms for the in silico prediction of RNA targets. A special focus will be directed towards small RNAs from pathogenic bacteria and on human small RNAs that are implicated in human diseases, including common forms of cancer. Research on both these topics should generate vital knowledge applicable for future therapeutic intervention. Multi-protein complexes and other protein components will be studied that are required for the generation or function of small RNAs and that are of potential biotechnological interest. Finally, we will study structural and functional aspects of small RNAs to elucidate mechanisms of interaction with the targets. The experimental strategies will pursue multidisciplinary approa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'MiCrovasculaR rarefaction in vascUlar Cognitive Impairement and heArt faiLure' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Vascular dementia and heart failure represent major health burden to morbidity, mortality and quality of life. Comorbidities (hypertension, aging, diabetes, etc.) affect all organs, but the brain and heart are especially sensitive to these chronic stresses resulting in cognitive impairment (a mental disorder) and heart failure (a non-mental disorder). These comorbidities also induce a reduction in microvascular density, called microvascular rarefaction. We have build a consortium, CRUCIAL, which will develop a coordinated program to investigate the role of microvascular rarefaction in cognitive impairment and heart failure.Diagnosis of microvascular rarefaction is limited by the inability to assess microvascular density. We will develop advanced imaging tools taking advantage of the newest MRI technology including non-contrast and artificial intelligence methods to assess brain and heart microvascular rarefaction. We will also develop other non-invasive measures that will be cheaper and easier to widely disseminate in clinical practice (sublingual and retinal microvascular imaging, and blood microvesicle analysis). We will then apply these techniques to prospective and retrospective patient cohorts with cognitive impairment and heart failure to demonstrate that rarefaction can be used as a biomarker to diagnose and stratify patients. Microvascular regression is now recognised as an active process. We will therefore investigate, through animal models, the molecular mechanism of vessel rarefaction in the presence of comorbidities that could be targeted therapeutically.Therapeutic options for cognitive impairment or heart failure are currently limited to treating co-morbidities. The aim of CRUCUAL is to deliver diagnostic tools to clinician and therapeutic pathways to phar