RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Retrograde atrophy induction: a paradigm shift in prostate and  pancreatic cancer prevention and therapy.' (PROPANTHERA), addressing dissemination and exploitation.

assistant: **Impact**

Pancreatic cancer (PaC) is a leading cause of cancer-related death in the Western world and its incidence is increasing. Prostate cancer (PrC) is the 2nd most frequent cancer in men and the 5th leading cause of death globally. These tumors arise in exocrine glands with secretory ducts. Standard treatments like the Whipple procedure or radical prostatectomy are aggressive and carry significant morbidity. PROPANTHERA proposes a first-in-class, minimally invasive alternative: targeted radiofrequency ablation (RFA) of exocrine ducts to induce localized retrograde atrophy leading to functional elimination of preneoplastic lesions and tumors. This breakthrough is enabled through the design of novel ultra-miniaturized catheters developed by world leaders in bioengineering and surgical oncology, enhanced by key expertise in state-of-the-art genome editing and genomic biology tools. The project builds on strong prior evidence in mice and uses tools ready for translation. Preclinical validation will use genetically engineered swine models mimicking human KRAS/TP53-driven and BRCA2-associated pancreatic cancer. For the first time, we will ablate lobular structures in the pancreas and the prostate in vivo, offering a precision medicine, organ-preserving approach.PROPANTHERA pioneers a paradigm shift: replacing resection with precision-guided atrophy. This approach will reduce complications, costs, and recovery time. Its impact will be highest in high-risk patients and those unfit for surgery. PROPANTHERA will not only redefine the treatment of PaC and PrC but it will also inaugurate a new class of organ-preserving interventions for a wider range of malignancies. The new medical devices, with a clear path to CE marking, and the strong biology to guide further refinement align with E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A completely biological and human tissue-engineered mesh produced from Cell-Assembled extracellular Matrix (CAM) in vitro for the treatment of Pelvic Organ Prolapse (POP)' (CAM) under Horizon Europe.

assistant: **Objectives**

Pelvic Organ Prolapse (POP) is a major medical issue for women. It is estimated that 1 in 10 women will undergo a surgery to treat POP during her lifetime. To provide mechanical support to the slipping organ, strong and stiff synthetic meshes have been used. Transvaginal meshes are now withdrawn from the market in many countries due to high complication rates. Hence, there is a strong medical and societal need for breakthrough innovations.We propose a new paradigm targeting the fundamental problem of synthetic meshes, i.e., the foreign body reaction, by providing a completely biological, tissue-engineered mesh to treat POP. Our strategy is based on a unique, biological material: the Cell-Assembled extracellular Matrix (CAM) produced by cells in vitro. Robust CAM sheets are cut to produce yarn subsequently knitted into a mesh.In 12 months, this proof of concept (PoC) aims to deliver unambiguous experimental evidence that a CAM-based tissue-engineered mesh has the potential to become a relevant alternative surgical solution to treat POP. This project is divided in 2 main tasks:1) Production and mechanical characterization of a human CAM mesh, and of an equivalent ovine mesh, with properties justifying a preclinical test.2) In vivo validation of an allogenic CAM mesh in a female sheep model at 2 and 6 month.This PoC will provide:1) Proof that a human CAM-based knitted mesh can have clinically relevant mechanical properties;2) Demonstration that an ovine CAM mesh can be successfully implanted to treat POP in a clinically relevant, allogeneic, large animal model;3) Direct comparison between the biointegration of an ovine CAM mesh setting and the inflammatory response to a synthetic mesh.Overall, this PoC will increase the technology readiness level of our product from 1-2 to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '(Magneto)Chiroptical spin crossover switches – from crystals to nanomaterials' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The MagChirSwitch MSCA-PF project pioneers cutting-edge chiral Fe(II) and Fe(II)Ln(III) materials, leveraging spin-crossover (SCO) phenomena to achieve unprecedented control over chiroptical and magneto-chiroptical effects. Focusing on magneto-chiral dichroism (MChD) and (magnetic) circularly polarised luminescence ((M)CPL), MagChirSwitch aims to be the first to follow these phenomena over Fe(II) transitions, driven by the design of innovative chiral SCO complexes. The bistability of Fe(II) ions between paramagnetic and diamagnetic states offers breakthrough potential for switching chiroptical properties – an unexplored frontier that could redefine magneto-chiral materials and expand SCO applications.The project unfolds in two phases. The first focuses on the development of chiral SCO crystalline materials and the successful detection of MChD and/or (M)CPL switching, triggered by temperature (thermally-induced SCO) or light (light-induced excited spin-state trapping, LIESST). This molecular approach enables precise design and rapid optimisation of magnetic and chiroptical properties. The second phase pushes the boundaries by transferring these magneto-switching effects to nanomaterials, advancing their real-world application potential. Nanomaterials that retain these switching abilities will enable scalable production, such as thin films for next-generation magneto-chiroptical devices. Additionally, transitioning to nanoparticles may reveal novel phenomena, such as shape changes linked to Fe(II) spin transitions.MagChirSwitch will profoundly enhance the post-doctoral fellow’s expertise by exposing her to advanced synthesis and measurement techniques (including MChD measurements during short visits at LNCMI, CNRS), as well as interdisciplinary collaboration. This experie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A novel amorphous silicon cell-based solar cogeneration system using the coupled thermal storage/organic Rankine cycle as an alternative to battery'.

assistant: **Innovation**

The indicative start date is 01 January 2017.This fellowship will bring an excellent young researcher (Dr Jing Li), the winner of Springer Thesis Prize and Excellent PhD Graduate Award of the President of Chinese Academy of Sciences, to investigate a medium temperature photovoltaic/thermal (PVT) system incorporated with the coupled thermal storage/organic Rankine cycle (ORC) as a novel alternative to battery. Due to its unique positive power temperature coefficient, the efficiency of amorphous silicon (a-Si) cell can be higher than that of a crystalline silicon (c-Si) cell when the operating temperature is above 100°C, at which heat is able to drive the ORC. This has therefore stimulated the applicants to propose the a-Si PVT-ORC system which combines the respective advantages of PV and solar ORC technologies. The a-Si PVT-ORC system is estimated to have an overall electrical efficiency up to 12.8% at 120°C, which is comparable to the c-Si PVT system at 75°C, but the former can eliminate expensive battery and use the coupled thermal storage/ORC instead, offering more economic and environmental benefits.The proposed project will offer an excellent opportunity of training and development for the very promising young researcher. The project has been carefully designed to match Dr Li’s expertise in solar thermal power systems and the expertise of the University of Nottingham in CHP, BiPV, CFD and 3D printing technologies, and thus facilitates a two-way knowledge transfer. Successful completion of this fellowship will contribute to the European excellence in solar power technology, and promote the professional competence and career prospect of Dr Li. He will share his knowledge and expertise on ORC and a-Si cell techniques by hosting a series of seminars for EU researchers a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Operational project for integrated urban management'.

assistant: **Concept**

1- To design and implement a range of physical traffic management measures in six cities (Liverpool, Gent, Heidelberg, Nantes, Patra, Utrecht). These measures will be in the areas of parking management and guidance, traffic calming and bus priority measures.2- To evaluate the impact of the measures on transport efficiency, safety and modal split in urban areas, with particular reference to the impact on vulnerable road users.3- To make recommendations for the future development of urban transport policies taking account of different urban environments including legal and institutional barriers, the need to improve the quality of life and the needs of different users of the urban transport system (including elderly and disabled persons) %Liverpool (UK), Gent (BE), Heidelberg (DE), Nantes (FR), Patra (GR), Utrecht (NL) %For task 5.1.3/7 a second contract has been awarded to the CAPTURE project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'International, Interdisciplinary and Intersectoral Postdocs' (PSI-FELLOW-II-3i).

assistant: **Innovation**

Large-scale research facilities are enabling cutting edge research and innovation in important domains such as materials science, health and energy. A number of such accelerator facilities is currently under construction in Europe and will become operational within the next ten years. Thus, there is a growing need for highly qualified researchers trained in interdisciplinary research at such facilities and also an increasing demand from companies to use these facilities for developing and testing innovative products.The Paul Scherrer Institut (PSI), one of Europe’s leading research centres and particularly renowned for its accelerator facilities and long-standing industry collaborations, intends to establish a novel post-doctoral research programme with new interdisciplinary and inter-sectoral training elements.PSI features a unique combination of excellent research facilities, including neutron, muon and light sources and (as of 2016) an X-ray free electron laser, which all exceed the possibilities of universities or industrial research centres. Motivated by the successful implementation of the FP7 COFUND programme PSI-FELLOW, PSI now wants to take post-doctoral education to the next level and proposes to set up PSI-FELLOW-II-3I. This 5-year programme will offer a total of 60 fellowships of two years duration each. The fellowships will be awarded in two calls for proposals with 30 fellowships in each call. In order to maximise the benefit for the fellows and offer the widest possible range of research topics, PSI has teamed up with 16 partner organisations (9 research institutions and 7 companies). The unique setup of PSI-FELLOW-II-3i will allow using synergies with other leading research institutions for the training of the next generation of researchers specialised i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ecological aspects of stress resistance in a migratory bird, the barn swallow' under Fourth Framework.

assistant: **Concept**

Environmental stress may give rise to increased levels of developmental instability measured in terms of fluctuating asymmetry (random deviations from bilateral symmetry in morphological characters), but also deviations from optimal physiological and immunological performance. Linking developmental instability to physiological condition and fitness is an unexplored avenue of research in behavioural ecology which will allow assessment of how environmental conditions mechanistically affect the development of phenotypes and the consequences of such phenotypes for reproductive success. An understanding of the magnitude of the stress factor imposed by migration relative to other stresses in the life history of birds could be used to predict the effects of climatic change on bird populations. Developmental instability in morphological characters is particularly important in migratory birds. Barn swallows are highly sensitive to environmental stress because foraging, migration to Afiica and other activities are highly dependent on weather conditions, and males have an elongated, costly tail due to a directional female mate preference. The main aim of the present project is to determine during which part of the annual cycle of the barn swallow conditions are most stressful as experienced by the swallows themselves, and to make a comparison in this respect between Danish and Spanish populations, which migrate over different distances. Measurements of fluctuating asymmetry will be related to data on physiological condition, immonucompetence and breeding success. Environmental stress will also be simulated by manipulation of tail length. The research training will take place in a stimulating international environment, with Dr A.P. Moeller, Dr N. Saino and Pro? F. de Lope, experts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Strong Probabilistically Checkable Proofs' (STRONGPCP).

assistant: **Innovation**

Probabilistically Checkable Proofs (PCPs) encapsulate the striking idea that verification of proofs becomes nearly trivial if one is willing to use randomness. The PCP theorem, proven in the early 90's, is a cornerstone of modern computational complexity theory. It completely revises our notion of a proof, leading to an amazingly robust behavior: A PCP proof is guaranteed to have an abundance of errors if attempting to prove a falsity. This stands in sharp contrast to our classical notion of a proof whose correctness can collapse due to one wrong step. An important drive in the development of PCP theory is the revolutionary effect it had on the field of approximation. Feige et. al. [JACM, 1996] discovered that the PCP theorem is *equivalent* to the inapproximability of several classical optimization problems. Thus, PCP theory has resulted in a leap in our understanding of approximability and opened the gate to a flood of results. To date, virtually all inapproximability results are based on the PCP theorem, and while there is an impressive body of work on hardness-of-approximation, much work still lies ahead. The central goal of this proposal is to obtain stronger PCPs than currently known, leading towards optimal inapproximability results and novel notions of robustness in computation and in proofs. This study will build upon (i) new directions opened up by my novel proof of the PCP theorem [JACM, 2007]; and on (ii) state-of-the-art PCP machinery involving techniques from algebra, functional and harmonic analysis, probability, combinatorics, and coding theory. The broader impact of this study spans a better understanding of limits for approximation algorithms saving time and resources for algorithm designers; and new understanding of robustness in a variety of mathemat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'From zebrafish to man Modifying amyotrophic lateral sclerosis (ALS): translation of biology into therapy' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor neurons. As for other neurodegenerative disorders, translation of newly acquired biological insights into therapies has been difficult. In the current project we intend to contribute to the development of therapeutic approaches for ALS. We want to generate novel models, identify new therapeutic targets for intervention, and translate these into validated options for drug development in ALS. This will be done by establishing a continuous line of research from the (unbiased) screening for targets in a small animal model (zebrafish), to the exploration of their therapeutic potential, and the validation in patients. In addition, by exploring the significance of some of the findings for other neurodegenerative disorders, we hope to demonstrate this approach to be valid for the field of neurodegenerative disorders in general. This research will be performed bases on 6 work packages (WP): 1.screening of a zebrafish model for ALS to identify therapeutic targets; 2. validation of these targets in larger vertebrate ALS models; 3. investigation of the mechanism of action of these targets in order to establish approaches to interfere with them; 4. validation of these targets in human ALS; 5. generation of preclinical data on these targets; 6. exploration of the possible role of these targets in other neurodegenerative diseases.Results from WP1 will be used for further research in WP2, results from WP2 in WP3, etc. We have gathered a large set of data in preparatory work in zebrafish, enabling us to start all WPs from the beginning of the project on.This project involves collaborations with several other groups, national and international, which all have been established. Furthermore, all transgeni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'NanoTribochemical Investigation of Advanced Lubricants' (NanoTrIAL) under Horizon 2020.

assistant: **Objectives**

Energy and resource losses in moving mechanical components as a result of friction and wear impose an enormous cost on national economies and thus call for the development of new design strategies, engineering systems, and materials with improved properties. Besides allowing significant economic savings, the reduction of frictional losses and the protection of mechanical components from wear can also have beneficial environmental effects, i.e., a reduction in the emission of carbon dioxide or other greenhouse gases.The goal of the proposed project is to develop an understanding of the mechanism(s) of surface molecular reactivity of a new class of “green” lubricants, i.e., ionic liquids (ILs), under mechanical stress. The gap in our understanding concerning the interaction(s) between ILs and solid surfaces leading to a reduction in friction and wear drastically hinders our ability to predict, control, and improve the behaviour of ILs and motivates the current project.Through the use of novel analytical methodologies that allow a multi-scale investigation of the processes occurring at buried sliding interfaces in the presence of ILs, insights into the origin of the promising tribological properties of ILs will be gained. The project has a strong multidisciplinary character and will greatly benefit from the expertise that the fellow acquired from his mobility between research institutions in different countries. Through NanoTrIAL, the fellow will broaden his scientific background, develop complementary knowledge in new areas, and increase his chances of success in academia.The broader impact of NanoTrIAL will be to aid in the rational design and synthesis of new, modified, and improved ILs that can reduce energy and resource consumption in advanced tribological application