RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular mechanisms involved in the phagosome-endosome fusion' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Phagocytosis is the uptake by cells of large particles into vacuoles. During this process, newly formed phagosomes fuse with endosomes and lysosomes. The Griffiths group has established the use of latex beads with macrophages as a model for studying phagocytosis, and set up an in vitro fusion assay between phagosomes and endocytic organelles. Several data suggest a role of actin in the phagosome-endosome fusion. I propose to characterize membrane and actin interactions, by identifying membrane proteins of the phagosome which directly or indirectly bind actin. The major proteins will be identified using high resolution 2D gel electrophoresis, and a collaboration could be set up with groups having expertise in molecular biology. This line of research will allow to more understand some steps in phagocytosis which plays a central role during host defense against infective agents.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'High throughput sequencing to reveal the causes and consequences of Mycobacterium tuberculosis genomic variation'.

assistant: **Concept**

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis in humans, is estimated to infect one third of the human population leading to circa two million deaths a year. While many work has been done onto the socio-economic and host factors affecting the different outcomes of the disease, little is still known about the possible influence of Mycobacterium tuberculosis strain variation. Compare to other bacteria, Mtb has very low polymorphism which have prevented until now a detailed study of the evolutionary forces behind this pathogen. With the advent of next-generation sequencing this gap in our knowledge on the population genetics of Mtb with respect other bacteria is starting to close. This project will be aimed to analyze 100 Mtb strains currently being sequenced by the Sanger institute using Illumina technology which added to our previous panel of 30 strains already generated will allow detail population genetics and evolutionary studies with an special focus on the evolution of known Mtb antigens. Collaborations with laboratories with expertise in immunology, transcriptomics and molecular epidemiology will allow us to put in context the consequences of the Mtb genomic variation found in this study.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Fundamental Research on Aircraft Wake Phenomena'.

assistant: **Innovation**

The aim of this project is to gain new knowledge on vortex phenomena, critical in the context of wake turbulence behind civil aircraft, but not sufficiently addressed or understood in previous studies. Many projects have investigated the behaviour of aircraft vortices, aiming at their characterisation and the search for means of reducing the associated hazard. Although a lot of information has been gathered, and much progress made in understanding these flows, some central questions remain unanswered, preventing major advances in this domain. They include: the precise role of vortex instabilities on wake decay, the effects of engine jets and fuselage wakes, and the influence of ground proximity on wake evolution, relevant to the airport environment. This project attempts to resolve these issues. Emphasis is put on the study of generic vortex configurations to gain the missing physical understanding, complementing the existing, mostly empirical knowledge. In support of new experimental and numerical investigations, theoretical/analytical treatment is applied, with the aim of obtaining a systematic description and understanding of the phenomena. Furthermore, extensive use is made of results/data from previous projects or available data bases on aircraft wake turbulence, whose analysis is far from being complete. The assessment of the impact of the new results on practical applications and realistic situations is an integral part of the project. It will create a solid knowledge base for the future development of strategies of wake prediction and reduction, relevant for increasing capacity and safety of air transport, one of the priorities of the EC work programme. The use of a concentrated effort to solve outstanding problems on a fundamental physical level, involving many
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Electric Propulsion Innovation and Competitiveness' (EPIC) under Horizon 2020.

assistant: **Objectives**

EPIC proposes a Programme Support Activity which will produce a clear integrated roadmap & masterplan for its implementation through a Strategic Research Cluster (SRC) on In-space Electrical Propulsion & Station-Keeping.EPIC plans to do a survey of the current worldwide Electric Propulsion (& related) technologies & their TRL. A collection of requirements from all stakeholders will be done, also assessing potential future missions. Both tasks will build on the 2014 EP Harmonisation & the consultation will be expanded to all EU actors. This will allow to focus efforts on the SRC roadmap’ specific goals.Based on this work, a critical gap analysis of technologies & needs will be done, to create the basis for selection of candidate SRC developments, oriented to satisfy short-term (incremental advances) & medium/long term (disruptive) needs.Then the prioritisation will be the driver & challenge, leading to the selection of activities for an SRC roadmap & masterplan for its implementation, aiming at a validation flight in 2023 & to contribute to European leadership in EP technologies.EPIC will provide a solid & widely consulted advice to the EC on the call texts for operational grants & continuous support to EC/REA to maximise the SRC success. EPIC will analyse the SRC progress, evaluate its risks & put a mitigation plan in place, including the Collaboration Agreement.The EPIC consortium will disseminate its progress & results, & intends to contribute to the SRC results’ dissemination not only with an exploitation plan but also by exercising a close coordination with all operational grants.EPIC is coordinated by ESA & complemented by renowned National Agencies: ASI, BELSPO, CDTI, CNES, DLR & UKSA, & by the major European space industrial associations, Eurospace & SME4Space. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Circuits of con-specific observation', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

A great deal is known about the neural basis of associative fear learning. However, many animal species are able to use social cues to recognize threats, a defence mechanism that may be less costly than learning from self-experience. We have previously shown that rats perceive the cessation of movement-evoked sound as a signal of danger and its resumption as a signal of safety. To study transmission of fear between rats we assessed the behavior of an observer while witnessing a demonstrator rat display fear responses. With this paradigm we will take advantage of the accumulated knowledge on learned fear to investigate the neural mechanisms by which the social environment regulates defense behaviors. We will unravel the neural circuits involved in detecting the transition from movement-evoked sound to silence. Moreover, since observer rats previously exposed to shock display observational freezing, but naive observer rats do not, we will determine the mechanism by which prior experience contribute to observational freezing. To this end, we will focus on the amygdala, crucial for fear learning and expression, and its auditory inputs, combining immunohistochemistry, pharmacology and optogenetics. Finally, as the detection of and responses to threat are often inherently social, we will study these behaviors in the context of large groups of individuals. To circumvent the serious limitations in using large populations of rats, we will resort to a different model system. The fruit fly is the ideal model system, as it is both amenable to the search for the neural mechanism of behavior, while at the same time allowing the study of the behavior of large groups of individuals. We will develop behavioral tasks, where conditioned demonstrator flies signal danger to other naïve ones
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Food Circuits: Hidden Connections between Migrants and Societies', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Most fruit and vegetables required and enjoyed by European and North American societies would not be possible without the planting, harvesting and transporting performed by migrant labourers. Yet, the contribution of migrants to crucial food systems is generally hidden in the experience of buying and consuming food. In this project, I take asparagus from Germany, oranges from Spain and strawberries from California as the vantage points from which to see connections between migrants and societies as well as the ways in which those connections become invisibilized. I focus on embodied experiences in food circuits in order to understand the labour of producing and transporting food and the process of consuming and incorporating food into oneself. Tracing asparagus, oranges and strawberries through their circulation, I investigate the embodied experiences of migrant farm labourers – who are treated simultaneously as essential, disposable and sometimes prohibited; supply chain workers – who are made up increasingly of migrants and work under tight delivery time constraints; and consumers – who eat with diverse intentions of survival, enjoyment, identity and ethics. I propose a new way of seeing social and embodied connections between migrants and societies – through the beauty, brutality and necessity of food. With FOODCIRCUITS, I will provide novel contributions on three primary fronts:(i) developing a theory of connections between migrants and societies – including on embodied levels – by following fruit and vegetables as they circulate from the hands that pick them, through the arms that deliver them to the mouths that eat them; (ii) re-conceptualizing the ways in which indirect connections between different categories of people are invisibilized through the infrastructur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Super-resolution Fluorescence Microscopy based on Artificial Mesoscopic Structures'.

assistant: **Innovation**

Studies of the dynamical process of biological samples benefits from real-time imaging microscopy which can provide wide-field high resolution with sufficient material contrast. Hence, fluorescence-based microscopy has become one of the essential tools of modern biology. However, fluorescence techniques as other optical tool suffer from a fundamental resolution limit due to the wave nature of light. While resolution is denoted by the ability to discern different objects, much effort has been devoted to improve the spatial resolution of far-field fluorescence microscopy and it has spurred the emergence of many innovative techniques. Stimulated Emission Depletion (STED) microscopy has shown the best lateral resolution among the far-field techniques. However, based on point scanning, it is too slow to catch fast molecular dynamics in an image time series. Photo-activated localization microscopy (PALM) and stochastic optical reconstruction microscopy (STORM) are equally powerful techniques that strictly spoken do not improve the spatial resolution, but the localization precision to pinpoint single molecules. The major drawback is that image acquisition is time consuming and thus makes them even less compatible for fast real-time imaging. Henceforth, the lifesciences community is still missing a microscopy technique that provides both high speed and super-resolution. To hurdle these limitations, we propose a fluorescence method that is based on artificial mesoscopic structures that are fully biocompatible and allow for super-resolution imaging of molecular dynamics in live cell with video-rate acquisition speed. Using an artificial mesoscopic structure one can manipulate light and design new components not previously realized such as a “perfect lens”. It has the potential fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'LIGHTCAP: Light, Cognition, Attention, Perception'.

assistant: **Innovation**

Cognition, Attention and Perception (CAP) are crucial for professional success, core to educational success, essential to productive, safe and healthy functioning. Yet cognition is hard work, attention is fragile, and perception is selective. Recent research has shown that light directly and indirectly helps CAP, in particular via the activation of a recently discovered photoreceptor in the human eye. Light triggers this photoreceptor, but large-scale migration to cities, increased time spent indoors, and our 24-hour economy have impacted on our light exposure. Disturbance of sleep/wake cycles, fatigue and cognitive failure, mood disorders and even cancer pathologies may be the consequences of ignoring findings on human light processing.  The urgent message is that light can make or break health, social and cognitive functioning. Given the rapid technological developments in light sources (LED, OLED) and the proliferation of intelligent infrastructures (IOT, data science), we are in a crucial period for the realization of truly human-centered lighting.LIGHTCAP aims to address this challenge by providing a strong, innovative and necessary impulse to our insight in the intricate and complex relationship between light, perception, attention and cognition. The goal of LIGHTCAP is to prepare the next generation ofexperts able to deliver on the promise of truly intelligent, human-centric lighting. We promise an international, interdisciplinary, cross-sectional and translational training program. It unites experts from neurobiology, cognitive neuroscience, chronobiology, psychology and lighting technology. It will train a generation of researchers who can look beyond the borders of their discipline and understand the implications of their findings for other fields.


**Keyword
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of an innovative plate multi-effect evaporator for seawater desalination' under Fifth Framework.

assistant: **Concept**

Water scarcity is a global major concern. The use of alternative water sources, such as desalination, is a high potential solution in sustainable development perspective. A qualified workforce has been implemented to promote research and development of an innovative desalination process, based on plate Multi-Effect Distillation, which focuses on four attractive points: low investment and running costs, construction-friendly, high modularity, low-level energy requirements. Economic, political, end-user issues and environmental considerations influence the challenging water desalination market. Water management and desalination policies have to be considered at a regional, social and economic scale. A user-oriented market analysis will enhance the pertinence of the dissemination phase up to industrialisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Scaling biological e-methanation as a Green Deal building block' (Echaea).

assistant: **Concept**

The decarbonisation of natural gas – the biggest energy import product into the EU today – through the production of renewable methane from bio-e-methanation (“e-methane”), a natural gas equivalent, is one of the cornerstones of the European energy transition. Our highly productive microorganism strain and pressure bioreactor design carry the potential to solve the challenge of providing cost-effective large-scale energy storage and a multi-purpose e-fuel. Echaea are the only company worldwide to have validated a biological methanation technology in industrial prototypes that turn CO2 into e-methane, using curtailed renewable power, and storing it in existing gas grids. The fully biogenic e-fuel can be used across sectors, for transportation, power generation or industrial heating. Our technology has shown to produce grid-quality e-methane in a continuous process at a 1MW scale (Biofos, DK Solothurn, CH) and now needs to be scaled up to commercial size. The EIC grant funded project will de-risk Echaea’s Power-to-Methane solution to market-readiness. Subsequently we will build a full 10MWe commercial demonstration plant at Roslev, Denmark, funded by the EIC equity facility. Once industrial operations have been demonstrated, the technology is ready for international roll-out. Expressions of interest for 12 10MWe plants have already been received. We have assessed a market potential today of around 500 biological methanation plants and of 5,000 in the EU, more around the world, by 2050. Green Deal impact: One 10MW plant will convert 5,700 mt of CO2 a year and produce 2,8m Nm3 e-methane, sufficient to heat 2,400 homes. By 2050, this technology could convert 0.8% of annual CO2 released in the EU. Echaea is a venture-backed company and co-led by a female executive, Doris Hafe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A clinical phonetics laboratory service (PhonLab): diagnostics of speech impairment via the web' (PhonLab).

assistant: **Innovation**

In line with present trends to expand eHealth in medical care, this project‘s objective is to provide a commercial web-based service for the automatic diagnosis of impaired speech, given a sample of the client’s speech transmitted over the internet. Currently, speech therapists are required to diagnose speech impairments from only a pen and paper analysis of transcriptions based on auditory impressions. The main advantage of the innovative approach of this project is to quantify the production of speech in time according to the scientific state of the art, which is well beyond the scope of presently used impressionistic, auditory techniques. This will be implemented by enhancing a prototype web-based system with software created during the PI’s ERC Advanced Grant for processing acoustically multilingual adult and child speech data.The overall long-term vision is to provide a web-based resource for diagnosing speech disorders from anywhere with access to a microphone and internet connection. As a first step, the proof-of-concept (PoC) will initiate a start-up process to bring this resource, known as PhonLab, to the point of commercialisation in Germany.  The work plan of the PoC consists in (1) the development of a business plan based on PhonLab’s likely usage and associated revenue (2) technically enhance  PhonLab’s automatisation and user-friendliness (3) developing a promotion strategy towards potential users and clients.The proximate economic benefits lie in the low costs and the rapidity of diagnosis even to remote places. In the long run, PhonLab has therefore also the potential to provide speech therapists in disadvantaged areas of the world with easy access to state-of-the-art techniques for diagnosing speech impairments