RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel business on DURable and COMPostable products based on REcycled plastic' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

More than 25 million tonnes of plastic waste are produced every year in the EU28 (50 kg per EU citizen). Although the rates of plastic waste recovery have increased (26% mechanical recycling; 35.6% energy recovery), 38.4% of this waste is still landfilled (9.6 million tonnes). This goes against the EU Waste Framework Directive 2008/98/EC as it has a high environmental impact (0.105kg CO2/kg plastic waste landfilled; production of one million tonnes of CO2) and wastage of resources (€590/tonne of recycled plastic ; losses of €5,664 M).INTERVAL, S.A. is a family-owned business created in 1982 specialised the recycling and transformation of plastics. We employ 22 people and have an annual turnover of €3,240,066. We produce more than 7,000 tonnes of plastic products per year using the most advanced technology in our production processes.Through ReDurComp, we aim to launch innovative, low-cost products onto the EU market based on premium recycled PE. We will start by introducing two products for which a clear market need has been identified (i.e. plastic sacks for household waste collection and plastic covers for pallets). As a whole, sales of about €48.3 million are forecast within a five-year period, generating profits of over €4.8 million. During phase 1, a feasibility study including a business plan will be developed  in line with the overall internationalisaton and growth plan of our company. This study will include: (1) a market assessment to confirm INTERVAL’s products acceptance in the two segments considered; (2) a technical assessment to validate our recycled PE material according to relevant EU standards and procedures, as well as final testing; (3) a stakeholder assessment to identify the key players and activities for the second and third phases of the project;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Single-shot X-ray Pulse duration Acquisition (SiXPAc)&Time-Resolved X-ray spectroscopy on molecules (T-ReX)' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Three-dimensional (3D) imaging techniques to investigate the spatial composition of crystalline materials and biological specimens have over the last decades been steadily refined to their current nano-scale resolution. However, nearly all of the methods relying on X-ray or electron 3D tomography only deal with static samples and cannot convey simultaneous information about structural changes. One very promising approach in this direction is to make use of ultrabright state-of-the-art X-ray sources, so-called free-electron lasers (FELs), which routinely produce coherent X-ray radiation with unprecedented intensities. Combining the high spatial and ultrashort temporal resolution of X-ray pulses for a full 4D characterization of the complex samples has been a long-standing goal of material and biological science.Due to the ultrashort duration of FEL pulses currently no measuring technique is able to precisely determine their time structure. The first step of this project at the LCLS will demonstrate a technique capable of measuring the X-ray pulse duration for every single shot with a precision of a few 100 attoseconds utilizing photoelectron streaking spectroscopy. This method will in addition permit us to directly investigate the substructure of the FEL pulses on an attosecond time-scale.In the second step we want to apply these pulses for time-resolved X-ray absorption spectroscopy: A UV pulse initiates a molecular reaction and the X-ray pulse is used as a probe, in effect sampling the dynamics of the complex system in real-time.The project would firstly greatly profit from the knowledge on ultrafast optics the applicant acquired over the past 4 ½ years at the MPI of Quantum Optics and secondly provide him with first-hand experience in the novel field of FELs at the mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dissecting the role of transcription in meiotic DNA double-strand breaks patterning' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Meiosis is a specialized cell division process for producing gametes, and meiotic defects frequently cause infertility or birth defects (e.g. Down syndrome). Successful meiosis is ensured by the induction of hundreds of DNA double-strand breaks (DSBs) at the correct chromatin sites. The pattern of DSBs is suggested to be controlled by some special chromatin features that are established upon transcription. However, as transcription is essential for life, it is difficult to directly study whether and how transcription influences DSB patterning during meiosis in common model organisms.The unicellular protist Tetrahymena thermophila has two nuclei and, importantly, transcription can be shut off in the meiotic nucleus without affecting meiotic progression. Therefore, the DIRECT-DSB project was designed to overcome the intrinsic limitations of other model systems by investigating the impact of transcription on DSB patterning in Tetrahymena.Through in-depth collaborations with the host supervisor, who has a profound knowledge of chromatin biology, and with other leading researchers with expertise in meiosis, I will first characterize and compare DSB patterns and chromatin features in the presence and absence of transcription and then study potential correlations between DSB pattern alterations and transcription-induced chromatin alterations. The successful accomplishment of the project will (i) clarify the relationship between transcription and DSB patterning, which has been a much-debated topic in the meiosis field for many years; (ii) deepen our understanding of meiosis, which, in the longer term, may contribute to solving the problem of increasing infertility rates in the European Union and elsewhere; (iii) enable knowledge exchange and dissemination, and the establishment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'AAV-mediated Gene Therapy for Haemophilia A' (Genophilia).

assistant: **Innovation**

Haemophilia is a group of hereditary genetic disorders that impair the body's ability to maintain normal blood coagulation. Haemophilia A (clotting factor VIII deficiency) is the most common form of the disorder, occurring in ~1 in 5,000 males in Europe. Although different gene transfer strategies for factor replacement have been evaluated, several properties make adeno-associated virus (AAV) vectors the most promising. Most importantly, AAV directs long-term transgene expression from non-dividing cells in animal models after a single administration of vector. In addition, AAV has an excellent safety profile. Unlike other vectors of viral origin, AAV has never been associated with any human disease and is naturally replication deficient.The overriding goal of the proposal is to improve the probability that AAV-mediated FVIII gene transfer can be used to successfully treat patients with haemophilia A. To achieve this goal, the Fellow will 1) establish a simple and efficient GMP compliant manufacturing platform for rAAV-HLP-codop-hFVIII pseudotyped with serotype 8 capsid2) assess the safety and efficacy of this AAV vector encoding a novel, potent FVIII-variant in mice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Towards designer peroxidases: application of protein engineering techniques to the design of novel peroxidase biocatalysts'.

assistant: **Objectives**

Peroxidases are of strategic importance to industry because of their numerous applications, including: biosensor construction, diagnostics, food processing, remediation of waste water, decolourization of pulp paper and textiles so avoiding the use of chlorine, and in dye transfer inhibition (bio bleaching). This project's objective is to design 'improved' peroxidase enzymes by a combination of protein engineering and chemical modification techniques with: (1) increased stability towards heat, organic solvents and denaturants. (2) greater resistance to catalytic inactivation and damage by radical products. (3) enhanced activity during steady-state catalytic and chemiluminescent turnover. We will study four peroxidases with important commercial applications or potential: The most used cationic horseradish peroxidase (HRP C), Coprinus cinereus peroxidase (CIP), soybean peroxidase (SBP) and anionic horseradish peroxidase (HRP A2). Scientifically the project will: (1) study the factors at the protein level which control the stability and unfolding of these enzymes, in particular the role of Ca in stabilising enzyme structures. (2) Determine new peroxidase crystal structures. (3) Determine the structure of their high oxidation state intermediates using fast x-ray / Microspectrophotometer methodology. resonance raman and NMR spectroscopy will support these investigations (1)-(3). The industrial participants, Ortho-Clinical Diagnostics Ltd and Novo Nordisk A/S, desire improved peroxidases for diagnostic and industrial enzyme applications. For new peroxidases which are found to offer a significant performance advantage, a business evaluation will be completed to assess the overall benefit of replacing current reagents with those based on the new `engineered' peroxidases. The pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sustainable energy system for achieving novel carbon neutral energy communities' (SUSTENANCE), addressing dissemination and exploitation.

assistant: **Impact**

The overall purpose of the SUSTENANCE project is to set up sustainable energy systems for achieving novel carbon neutral energy communities. The project focus on the development of smart technological concepts ensuring a green transition of the energy systems with higher share of local renewable energy and more efficient integrated energy solutions for the electrical, heat, water, waste as well as transportation infrastructure. The set up solutions will at the same time have good socio-economic impact in the local communities and ensure ecofriendly solutions and good infrastructures, which provides support to sustaining the essentials of life. The demonstration activities are set up in four countries: Denmark, India, Netherlands and Poland. These countries has different local energy resources, socio-economic, user behavior, political structures, market conditions and regulations. The project will show how same technical concepts such as coupling of different energy vectors, storage solutions, demand response, intelligent control schemes and digitalization can be applied to all demonstration cases despite the huge differences in the local conditions and regulations. Road maps will be set up based on these technical solutions together with guidelines for methods for user engagement and ensuring cooperation among the users in relevant cases leading to cooperatives. Finally, business cases will be set up for the different demonstration sites seen from both user perspective, small enterprises and utility point of view taking into account the local conditions. In this way, synergy effects with inputs from the different demonstration sites are expected and the results give abundant possibilities for maximum impact and replication in other local communities in the four countrie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Visiting the Margins. INnovative CULtural ToUrisM in European peripheries'.

assistant: **Objectives**

Tourism is more than travelling and consumption; it has great potential when it comes to culture, nature, knowledge and personal experiences. Travelling is a way to learn and improve oneself, to enrich one’s vision and improve mutual understanding.The INCULTUM project deals with the challenges and opportunities of cultural tourism with the aim of furthering sustainable social, cultural and economic development. It will explore the full potential of marginal and peripheral areas when managed by local communities and stakeholders. Innovative participatory approaches will be adopted, transforming locals into protagonists, able to reduce negative impacts, learning from and improving good practices to be replicated and translated into strategies and policies. Furthermore, INCULTUM fosters intercultural understanding through the implementation of bottom-up strategies that can have positive effects for both, locals and tourists.Ten pilot cases of living territories and communities will be investigated and on the basis of the findings innovative customised solutions will be co-created. Additionally, pilots will be used to identify and compare drivers and barriers that account for the success or failure of participatory models. Pilots will also enable us to assess outcomes and analyse the pre-conditions needed for a future full implementation and scaling up of potential solutions.Pilots will provide new quantitative and qualitative data that will be combined with official statistics and novel data gathered by the use of self-developed IT applications and the exploitation of previously untapped data sources. The implementation of advanced econometric methods and the pioneering introduction of machine-learning tools into tourism research will push the boundaries of our knowledge.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel minimal-damage steel seismic-resistant frame' (MINDAMSEISMICFR).

assistant: **Innovation**

Conventional seismic-resistant structures are designed to experience significant damage in structural members and residual storey drifts under moderate-to-strong earthquakes. The losses associated with damage and residual storey drifts are repair costs and costly downtime during which the building is repaired and cannot be used or occupied. Under very strong rare earthquakes, conventional structures may be also vulnerable to collapse (life safety issue). In addition, past earthquakes showed significant damage in non-structural elements (walls, storage racks, acceleration-sensitive medical equipment, etc) due to large storey drifts and total floor accelerations. The aforementioned socio-economic risks highlight the need for minimal-damage structures with increased collapse resistance and the inherent potential to reduce structural and non-structural damage. The ambitious main objective of the proposal is the development of a novel minimal-damage steel frame that has the potential to: (a) address all the disadvantages of previously developed seismic-resistant steel frames; (b) experience minimal damage that can be rapidly repaired, and so, offer immediate return to building use or occupation after strong earthquakes; and (c) eliminate the probability of collapse (i.e., protection of human life) under very strong rare earthquakes. The project will develop fundamental knowledge, design details and criteria, and performance-based seismic design methods for the proposed novel steel frame by conducting state-of-the-art integrated experimental and analytical research. The project directly responds to the global need of societies for structures which are less vulnerable to earthquakes; drastically reduces the economic losses related to repair of structural and non-structural sei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Eu-japan workshop-access to research and development by higt-tech smes', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

SMEs are 99,8% of a EU companies and are the main employment provider (66%, sources Euro stat). SMEs are also paying a prominent role in Japan. Innovation is a strategic factor for SMEs even if they often show major difficulties in acceding to R&D results or in developing R&D activities on their own. Against this framework, specialised networks could play a pivotal role in bringing SMEs closer to R&D. In both the EU (about 400 members) and Japan (about 500 members) the Chambers of commerce system is wide and capillary, is catalyst of resources, promoter and co-ordinator of initiatives and is considered a focal point for different bodies/actors involved in R&D activities like development agencies, research institutes, etc. This network could better liase SMEs and R&D also according the EU subsidiary principle. In this context, Mondimpresa (co-owned by the Italian Union of Chambers of commerce and the National Federation of Industry) plans to organise a workshop between the EU and Japan aimed at promoting, on a permanent basis, an exchange of experiences and know-how in assisting SMEs to get closer to R&D. The workshop should take place in Rome during the first half of 2001.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Preventing 10.000 European hospital deaths by securing efficient hand disinfection through an automatic, easy to use, environmentally friendly and verifiable disinfection process (CLEANHAND)' (CLEANHAND).

assistant: **Concept**

Each year 2,8 million patients are infected while receiving treatment in European hospitals, these are referred to as nosocomial infections. These nosocomial infections cause patients to incur other illnesses and making treatment more complex. To the patient, hospital infections means a prolonged stay and more suffering at the hospital, and may also lead to permanent health damage or death. While statistics indicate many major causes of death are now decreasing, hospital infection deaths have doubled in 40 years. It is estimated that at least 10.000 people die from hospital infections in EU annually. International studies show that high intensity surveillance and infection control program can reduce the prevalence of hospital infections. Hence; high intensity surveillance and infection control programme with high focus on hand sanitation represents a potential for a 30 % reduction in hospital infections. The Community Network for the epidemiological surveillance and control of communicable diseases, established by the European Parliament and Council Decision 2119/98/EC is an example of the EU focus on hospital infections. Our project also contributes to the basis for EU objectives and actions with respect to combating hospital infections (Article 152 -ex Article 129). Despite there are no commercial Automatic Hand Sanitizers the market is estimated the potential annual global market for sale of apparatus' and sanitizing liquids at + 1,6Bn giving an EU market of +783m pa. Assuming a modest market penetration of 3% in EU and 2% globally and also including the health care sector outside the Hospital market segment, the potential market for the AHS is +310m pa. The objective of this project is to develop an Automatic Hand Sanitizer (AHS) that disinfects hands of nurses, doc