RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multiphoton Microscopy and Ultrafast Spectroscopy: Imaging meets Quantum' in the context of a Horizon 2020 call.

assistant: **Objectives**

In the quest to decipher the chain of life from molecules to cells, the biophysical questions being asked increasingly demand techniques that are capable of identifying specific biomolecules in their native environment at the smallest possible scale, and measuring their interactions quantitatively without perturbing the system under observation. Laser-based optical microscopy is a key technology to drive this progress in the 21st century. Still, many challenges remain in particular toward i) achieving imaging with biomolecular specificity without the artefacts from sample staining, ii) quantitative imaging, and iii) single molecule sensitivity. Progress toward biomolecular specificity at very high temporal resolution has been brought by the development of ultrafast two-dimensional electronic spectroscopy, able to address the importance of quantum coherences with the potential to unravel the fundamental machinery of Nature. Yet, measuring quantum phenomena with an optical microscope is technically challenging, and far from real-world biological applications. MUSIQ is designed as an innovative research and training network, where we will recruit 15 Early Stage Researchers to work toward the central ambitious goal of developing the next-generation optical microscopy exploiting quantum coherent nonlinear phenomena. The network brings together a unique team of 7 world-leading academics and 6 high tech companies at the forefront of optical microscopy and ultrafast laser technology developments merged with fundamental understanding of coherent light-matter interaction phenomena, development of quantitative image analysis tools, and biomedical/pharmaceutical real-world applications. MUSIQ will establish an intersectoral training and research programme at the physics/chemistry/l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Pannexin 1 – a novel target for pediatric orphan epilepsy'.

assistant: **Objectives**

Epilepsy is a group of syndromes with high unmet medical need, especially in children as frequent seizures affect the immature brain and its development. In some orphan syndromes, drug resistance is 70% with dramatic consequences for patients and their families. Novel treatments must prevent the negative effects of seizures, but also minimize off-target effects on brain development and cognitive functions. Our solution is the specific blockade of the activated form of the Pannexin 1 (Panx1) channel using a reformulated form of probenecid: PTI5803. This compound, a first-in-class drug, inhibits seizures preclinically in >80% of cases without hampering cognitive functions. Designed to be adapted to children (from 6 months of age) and to improve the bioavailability, PTI5803 is a highly specific breakthrough product to counteract the pathological activation of Panx1 in patients with an ultra-resistant orphan epilepsy, with the potential to disrupt the market of paediatric epilepsy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Legal Annotations Within Scandinavia', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The Legal Annotations Within Scandinavia (LAWS) research project will examine medieval legal manuscripts for notes left in the margins by readers; these additions include evidence for the changing understanding of the law across the medieval and post-medieval periods. The marginalia in these texts include reader reflections and erasures and I will examine these marginal annotations for insights into the ongoing reception and interpretation of the laws, including the circumstances of its evolution. This is particularly important because unlike the rest of Continental Europe, medieval Scandinavian legal manuscripts were less influenced by the Bolognian and Parisian law models, and similarly the reader annotations do not follow the customary glossing patterns. This provides an opportunity to examine a unique reading and legal culture that existed literally in the margins, some of which will only be visible and legible now after centuries due my use of the multi-spectral imaging scanner at the Arnamagnæan Institute. The main objectives of my research project are therefore to: 1) To examine the medieval legal texts in the Arnamagnæan Manuscript Collection for evidence of use by medieval and post-medieval readers; 2) To develop a detailed record of the marginalia, both standard and nonstandard, present in the legal texts in order to track the changing understanding of medieval legal terminology; 3) To consider the broader questions of literacy and the Nordic legal cultures as seen through two important 18th-century manuscript collections, which serve as a representative sample of the time; and 4) To produce an exhibition comparing the patterns of use on these medieval Scandinavian manuscripts to those used, read, and annotated in medieval England and Continental Europe. My re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Building multidisciplinary evidence to support Integrating Malaria VACcine with Seasonal malaria chemoprevention in West Africa' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Despite available efficacy data on two malaria vaccines designed for broad use, there is little evidence about scalable delivery strategies in areas with seasonal malaria transmission. We propose a multi-site, multi-disciplinary Phase IV cluster-randomized trial in Burkina Faso and Mali to evaluate the effectiveness, real-life impact, acceptability, feasibility and cost-effectiveness of a novel integrated delivery strategy of R21/Matrix-M in areas with highly seasonal malaria transmission.We will compare campaign-style vaccination co-administered during Seasonal Malaria Chemoprevention to vaccination following an age-based strategy in routine Essential Programme on Immunisation activities using a non-inferiority design. We will engage with all stakeholders to co-design the integrated strategy, collect malaria incidence data via surveillance and prevalence via cross-sectional surveys, generate data on coverage, assess feasibility and acceptability among stakeholders and end-users using qualitative longitudinal study methods, and describe the cost-effectiveness of both approaches, with costs and outcomes measured from the societal perspective. We will also use the trial platform to perform post-licensure pharmacovigilance of R21/Matrix-M. The project will ensure translation of results into policy and practice throughout areas of highly seasonal malaria transmission. It responds to SDG3, and is aligned with the Immunization Agenda 2030, particularly by testing a community-based vaccine approach that should reduce the number of “zero-dose” children. By leveraging the SMC platform, we hope to mitigate vaccine hesitancy.    Our multi-disciplinary approach aims to generate a comprehensive package of evidence that will allow policymakers to make informed guidelines for malaria
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Studies on a cohort of Serbian children exposed to x-irradiation to determine the contribution of the non-coding genome to susceptibility at low doses' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

The epidemiological study of Tinea capitis (ringworm) patients has proven useful for the study of carcinogenic effects of low dose radiation. In Dark.risk we will develop a new epidemiological cohort based upon the 24 000 cases irradiated in childhood that we will document to create the Serbian Registry of Tinaea Capitis Children (SRTCC). Unlike many other epidemiological cohorts SRTCC can be used to collect biological materials for molecular epidemiological studies.Dark.risk will prepare the way to use SRTCC biomaterials to quantify the contribution of individual differences in sensitivity to risk from low doses of ionizing radiation. We will focus on a novel and unique process to identify individual differences. Until recently 95% of the human genome was considered to be non-translated  “junk"" DNA. However, almost all of this “dark matter” is actively transcribed into a vareity of non-coding RNA species (ncRNAs) that regulate interactions with the external environment, such as repressing retrotransposons, regulating gene transcription responses to stress, governing chromatic remodeling and coordinating the translation of mRNAs.  The ncRNAs play an essential role in coordinating critical cellular responses to radiation such as maintenance of genomic  stability, senescence, apoptosis and survival. As ncRNAs make major contributions to individual disease sensitivity we will investigate precisly how the “dark matter” regulates responses at low doses (1mGy to 500mGy), and how these responses vary between individuals.Our long-term goal is to use ncRNAs as biological markers of exposure and outcome on an individual basis.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Improving science communication in museums and science centres' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The ISCOM projects aims at creating a SCIENCE communicators Forum during three Years, for exchanging and diffusing science centre/museums best experiences. For a better performance, ECSITE creates a Consortium including the BAAS (UK) and LABCIS-ITCOM based at the Futuroscope (F). The Forum will focus on three major challenges. We face today in the field of economy, communication and society changes. These three challenges will be analyzed over three years and evaluated from the point of view of the professional activity of the partners. The results will be largely disseminated by Printed matters and internet.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Deposition of encapsulated network of drugs to prevent remedial implant treatment emanting fromdeep bone infection.'.

assistant: **Concept**

Prosthesis implantation of the hip and knee are amongst the most common operations carried out, together with the shoulder and finger prosthesis implantation these account for 1.4m operations annually across Europe. Although the prosthesis implants and equipment used for their implantation is sterilised post operative infections occur, resulting in 50000 cases of deep bone infection and 193000 cases of superficial infection. These infections are the result of bacterial contamination during the operation, once removed from the protective packaging, or of contamination of equipment. Deep bone infections often result in the removal of 7% of prosthesis implantations, in severe cases, 9% result in the amputation of the limb. Upon removal of the implantation the patient can be left without an implant for days or months until the infection has been eradicated at which point revisional surgery is performed.Our idea:Develop a dendritic structured surface coating for prosthesis implants that will deliver antibiotics, anti- inflammatory, with bone promotional drugs to the potential sites of infection following implantation. It will be done by encapsulating the desired drugs in a polymer shell that will decompose at a set rate to give the desired drug release over a series of weeks or months. The polymer shells will be linked to each other and the implant surface by a series of opposing pole affinity bonds that will break down as a result of bio-chemical attack from the immune system resulting in the release of the polymer encapsulated drugs into the surrounding area, allowing both deep bone infection and soft tissue infection to be treated.Our aim: Develop a surface coating for prosthesis implants that will revolutionise the implant market by reducing the number of post operative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Characterization of the genomic variability of the 15q11-q14 region and its relationship with genomic disorders', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Human chromosome 15q11-q14 is characterized by genome instability, allele-specificmethylation and gene expression complexity. Several large segmental duplications relocated at this chromosome region and are known to mediate genomic rearrangements leading to genomic disorders. In addition to Praderj-Willi and Angel man syndromes, complex disorders like autism, schizophrenia and epilepsy are found to be associated with rearrangements of ISqII-qH. The understanding of the genomic organization of the 15q11-q14 regions is the first step towards the detailed analysis of the link between variants at the genomic or molecular level and specific disorders. All versions of the draft sequence of this region are still very preliminary and the understanding of its genomic organization is hampered by the large number of segmental duplications that it contains, the complexity of the orientation of the different copies of the segmental duplications, and the variability that exists in the general population and in parents of patients that suffer from disorders affecting this region. Complete supplicant map of 15q11-q14 has not yet been developed and the major breakpoints of rearrangements have not yet been characterized at a precise molecular level. One of the major goals of this project is to further study the detailed segmental duplications organization of 15q11-q14 and to detect the molecular mechanisms that predispose to their genomic rearrangements. The proposed project also aims to identify the breakpoints of rearrangements in patients with autism that carry either deletions or duplications of 15q11-q14. In these patients, gene dosage effect and/or genes with disrupted structure is likely tube a direct cause of disease. Analysis of molecularly defined rearranged segments will ident
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'CloudIX: Cloud-based Indexing and Query Processing' (CloudIX) targeting Seventh Framework.

assistant: **Abstract**

The advent of cloud computing comprises a new paradigm that entails a large number of low-end processors that perform parallel processing of (usually data-intensive and resource-demanding) computing jobs. This is particularly appealing for a wide variety of data-intensive applications, including scientific data management, analysis and mining of complex data, and internet-scale service provisioning. Nevertheless, processing complex queries in the cloud is still in a primitive stage, largely relying on the concept of map-reduce, without inherent indexing mechanisms that can boost the performance of query processing. In contrast, database research prides itself on scalable techniques for advanced query processing.CloudIX intends to transfer knowledge from data management technology to the cloud infrastructure, in order to support advanced query processing. To this end, CloudIX aims to propose a generic, distributed, dynamic and adaptive indexing framework for handling multidimensional data in the cloud. Capitalizing on this indexing infrastructure, CloudIX will present novel efficient algorithms for processing advanced query types, such as range, nearest-neighbor, top-k, rank joins, and skyline queries. Furthermore, CloudIX will propose new economical cost models that need to be tightly integrated in the process of query optimization.The research results of CloudIX are expected to act as a catalyst that attracts applications that rely on advanced query processing to be moved to the cloud. As a showcase scenario, two applications will be deployed on top of CloudIX, one related with scientific data management, to demonstrate the feasibility and efficiency of the proposed framework.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Choice and learning in a 3-dimensional environment: an investigation of brain and behaviour' (CL-3DE).

assistant: **Concept**

Recent research has shown that both humans and animals respond differently to rewarding objects when they are near compared to when they are far. I have developed a proposal to examine how proximity to rewarding objects impacts the brain, the choices we make and how we learn. This proposal has been explicitly designed to address the three key objectives of Horizon 2020. 1) Excellent Science: as a reintegrated researcher, I will transfer my knowledge of delivering immersive 3D stimuli in a laboratory setting to Jean-Claude Dreher's research group. Here, I will learn state-of-the-art techniques from the field of neuroeconomics to test the notion that a dual system network consisting of the striatum and hippocampus are critical to near and far choice outcomes. I will also test the notion that the same network is critical to how we learn about relationships in near and far space. 2) Competitive Industries: excellent immersive 3D will be essential to research outcomes. In the first of a two-part secondment, I will work with industry experts in visual effects to develop the highest quality stereographic stimuli for my experiments. Second, I will return to engage industry experts with my findings about how the brain is impacted by 3D screen imagery. 3) Better Society: I will engage with the public, especially younger people, from the outset to raise awareness about how the everyday choices we make can be influenced by environmental factors that we are often unaware of. I believe that this innovative research can have a significant impact on European society and industry and my career as a researcher.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Electro-optical light scattering and rheology of electro-rheological fluids' under Fourth Framework.

assistant: **Concept**

Research objectives and content The primary goal of this project is to achieve a better understanding of the aggregation process that promotes the electro-rheological (ER) effect which will yield the development of new electro-rheological fluids with industrial applications. The kinetics of chaining of the colloidal particles will be studied using electro-optical light scattering. This technique permits to follow structural changes in the ER fluids upon application of an electric field. The study will be performed with suspensions of monodisperse spherical particles as well as with polydiperse particles. The rheological behaviour of the ER fluid will be studied as a function of the shear stress and the electric field using concentric-cylinder or plate-plate geometries of rotational instruments. The changes in viscosity of the ER fluids upon the application of an electric field will be studied as function of the amplitude of the electric field and volume fraction of the suspended particles. The results of these investigations will yield new, important information on the input parameters for the modelling of ER fluids. Training content (objective, benefit and expected impact) Acquire skills in electro-optical LS and electro-rheology which are innovative techniques with potential applications in materials science. Links with industry / industrial relevance (22) The applications of greatest interest for electro-rheological fluids are in the transport industry automotive, air and marine - where applications of ER technology could result in large savings in fuel and energy.