RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Translation Control in Development: when, where and how' under Horizon Europe.

assistant: **Concept**

The translation of mRNAs by ribosomes is a key step in decoding the information stored in our genome. Animal development requires a strict regulation of translation, in particular when transcription is absent, as in most early embryos. A range of mechanisms ensure that mRNAs are translated with the right efficiency and location, in the right cell types and exactly when their protein products are needed. Disruption of this regulation can lead to developmental defects and embryonic lethality. Despite the recognized importance of translation regulation, the impact of translation regulation, and especially localized translation, on protein levels remains largely unknown for most genes. Furthermore, the mechanisms that drive localized and cell-type-specific translation are poorly understood, partly due to a lack of methods that enable the real-time visualization of translation in live embryos. The goal of this proposal is to discover translationally regulated mRNAs across the genome in early development, and reveal, with single-molecule precision, how spatiotemporal cues and cell type-specific mechanisms drive differential protein translation. Using ribosome profiling, we will create a genome-wide single-cell map of translation efficiencies during embryonic development of C. elegans, thus delineating the translation landscape that guides development. Using real-time single-molecule translation imaging, we will reveal how local translation patterns are formed and maintained between and within cells. Finally, we will explore how RNA-binding proteins modulate both translation efficiencies and spatial organization, to reveal the underlying mechanisms that drive translation during development. This combination of genome-wide and single-molecule studies will lay the groundwork for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Label-free microarrays for the parallel analysis of small (bio)molecules' (COMBIARRAY).

assistant: **Concept**

Microarrays- flat surfaces that bear hundreds or thousands compounds, each of which able to recognize a complementary molecule- are mostly used today in nucleic acid analysis, but the technology is not developed in the screening of small drug-like (bio)molecules.We propose to exploit the combinatorial parallel approach for the fabrication of small (bio)organic molecule microarrays on glass support, and to adapt the technique in order to screen directly the molecules for biochemical activity. The main innovation of the project is the original idea to attach both small (bio)molecules and fluorophores onto a glass substrate in the fabrication of the microarrays.The fluorophore, which plays the role of an internal read-out system, will allow a direct screening b y fluorescence microscopy without extra labels. The arrays will be prepared using either light-directed or microcontact imprinted fabrication. Using the first method, glass substrate functionalized with photodegradable protecting groups will be modified on specific areas by using photolithography masks.The areas deprotected with light can be reacted with first a (bio)molecule, secondly a fluorophore on the same site. Next, light is directed to another region of the substrate using a second mask, and the chemical cycle is repeated with a different molecule and a different fluorophore. The second method involves the use of a polymeric stamp coated with a solution of (bio)molecule or fluorophore, which is pressed onto the functionalized glass substrate.Molecules are transferred only at the place of direct contact between the stamp surfaces and the substrate. Screening of these microarrays upon addition of an analyte can then be performed simply using fluorescence microscopy. This new approach allows faster and cheaper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'REGENERATING NATURAL AESTHETICS' (REGENERA), addressing dissemination and exploitation.

assistant: **Impact**

Every Year, globally ca. 0.8 million people experience reconstructive surgery after mastectomy or lumpectomy and 1.2 million undergo breast augmentation surgery. Currently, breast defects are not properly reconstructed but only temporary filled with silicone implants, which however present several drawbacks such as the need of substitution after approximately 10 years, rupture (30% of incidence), leakage and capsular contracture. An alternative procedure that is currently available in clinics is fat autotransplantation. However, this technique presents potential carcinogenic risks and is still limited to small volumes, requiring multiple interventions to achieve larger reconstructions.REGENERA is an innovative mammary prosthesis based on biodegradable, porous, synthetic biomaterials and manufactured with internal micro-channels replicating the blood-vessels architecture. This distinctive combination, obtained by a patented process, promotes the natural fat growth, and allows the regeneration of a large adipose tissue volume. REGENERA’s overall objective is to improve patients’ quality of life, by restoring permanently the breast’s natural shape, appearance and size following a mastectomy/lumpectomy. Moreover, since REGENERA does not require further surgical operations for the rest of the patient’s life, it can drastically reduce the pain of the patient and decrease the associated Healthcare costs. REGENERA specific objective is to provide a biocompatible support able to induce the ingrowth of adipocytes and subsequently degrade, allowing the complete maturation of a stable adipose tissue, that replaces the original volume occupied by the prosthesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Human Computer Interaction Models forInteractive Exploration of Behavior Datasets' (INTERACTIVEX), addressing dissemination and exploitation.

assistant: **Impact**

The objective of the proposed research is to develop models of human computer interaction for exploratory data analysis. The research will be focused on the information presentation part of the interaction, especially: (1) interactive exploration of behavior data sets about dynamic systems that include spatial and temporal references; (2) automatic generation of natural language presentations from these data sets (e.g. summaries, comparisons) that are coordinated with mixed media (e.g. charts, timelines, maps, animations, etc.); and (3) adaptation of the generation process to the user and the interaction history.For this purpose, problem solving methods from the field of artificial intelligence will be used to support reasoning for abstraction, planning and configuration during the dialog process. Reusable knowledge sources will also be used in the form of available domain ontologies and knowledge extraction techniques from text and speech corpora in the development of specific components for dialog management and language generation, specifically freely available resources related to behavior data of dynamic systems (e.g., temporal knowledge, spatial knowledge, qualitative physical models, etc.).The research will follow a methodology based on two loops of design-implementation-evaluation of experimental prototypes: the first loop will be carried out during the ongoing phase and the second during the return phase. The goals of the research project include the generation of the products during the two-year project. These products include: (a) two corpora for experimentation purposes for two different domains based on real world problems; (b) two software experimental implementations supported by algorithms corresponding to the inference procedures and reusable domain kno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New Directions in Hybrid Inorganic-Organic Framework Materials' (NEWMATS).

assistant: **Innovation**

The proposed work is in the field of inorganic-organic hybrid materials, focusing mainly on dense rather than nanoporous materials. There are a huge number of opportunities in this area, especially now that is has become relatively straightforward to control the conditions under which dense, often anhydrous phases with excellent thermal stability can be synthesized. The latter have a wide range of interesting properties in terms of optics, magnetism, electronic conductivity, catalysis and so on. We shall work on such functional hybrid materials with potential applications in areas such as lighting and displays, photovoltaic cells, data storage, ferroelectrics, catalysis, and gas storage.  We shall also explore some of the fundamental questions concerning hybrid frameworks: What factors control their crystalline structures? Can we reliably simulate their structures and calculate their energies? What kinds of defects can be incorporated into hybrid frameworks? How do these affect their properties? What factors influence the mechanical properties of hybrid frameworks? Can we develop a general method for preparing nanoparticles of hybrids?  The work will involve a great deal of solution-based synthesis, chemical and thermal analysis, structure determination by single crystal X-ray methods, physical property measurements (mainly optical, magnetic, electronic, and mechanical), computer simulations, and some calorimetry. Most of the facilities needed for this work are available in Cambridge, though I shall collaborate with others where appropriate (e.g. computer simulation, calorimetry).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enhanced Reality For The Video' (ENREVI) targeting Fifth Framework.

assistant: **Abstract**

The ENREVI project proposes new development for the enhancement of a video sequence captured on a real scene with real-time rendered 3D objects. Emphasis is put both on real time and on economically affordable solutions. Research and development objectives include: Fundamental research will provide tools for tracking in unknown environment. Software real time engine that could render 3D synthetic image on affordable hardware platform. Format to generate, store and retrieve data in accordance with existing and future standards. New generation of chroma key product, software configurable. Integration of all different modules in a real life environment, under the specification and control of the end-user.Objectives:The ENREVI project proposes new development for the enhancement of real time video of real scene with real-time render 3D objects. Emphasis is put on economically affordable solutions.This generic technology will open a wide range of applications were Virtual object need to be merged into the real scene:* For a better understanding of action on television,* For aesthetics and creative additions on Tv programs,* For environmental impact analysis,* For Pre-visualisation of Cad/cam result in natural environment,* For Pre-visualisation of special effects in the movie industry,* For future Internet and Interactive television applications,* Some application in training and in medical imaging can also be considered.Work description:The ENREVI consortium plan to focus on the following points:1) Fundamental research will provide tools for tracking in unknown environment in real time. It includes: Hyper tracking system, feature system and tracking system and exploration of tracking without markers in arbitrary environment.These tracking solutions should be compatible with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Integrated Multiscale Process Units with Locally Structured Elements'.

assistant: **Innovation**

IMPULSE aims at effective, targeted integration of innovative process equipment such as microreactors, compact heat exchangers, thin-film devices and other micro and/or meso-structured components, to attain radical performance enhancement for whole proces s, thereby contributing to significant improvement in supply-chain sustainability for the chemical industry. IMPULSE offers new opportunities by encouraging the use of flexible, integrated equipment and process units with appropriately targeted multiscale structuring. The IMPULSE approach represents a PARADIGM SHIFT in chemical engineering : Rather than adapting operating conditions to equipment limitations, IMPULSE proposes to adapt the equipment, structure and process architecture to enable achievemen t of the most desirable operating conditions for a given physicochemical transformation. Impulse goals include proof of principle in several supply-chain sectors (pharma, fine chemicals, consumer goods), validated business models (e. g., distributed prod uction, mass customization, etc.), teachable generic design methodology and optimization and decision criteria for ecoefficiency.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Joint Agency in Groups'.

assistant: **Concept**

The sense of agency refers to the underlying feeling of control over our voluntary actions and the outcome(s) of those actions. Joint agency refers to the sense of agency when we perform voluntary actions with other people. This is the feeling we experience when we move a couch with a friend, build a Lego tower with our younger family members, play sports with friends, or even perform music with a band. Despite its essential role in social life, joint agency has received much less attention than work on individual sense of agency. Furthermore, extant work has primarily focused on dyads. Yet, actions are not done solely by individuals or pairs; indeed, the ability to work together in large groups and perform similar and complementary actions to achieve some goal (e.g., building a large house) undoubtedly played an essential role in the flourishing of human societies. As such, the aim of this research proposal is to fill this gap in the literature by investigating if and how joint agency changes in groups. To tackle this important issue, my work will involve a series of experiments, implemented in a Virtual Reality (VR) setting, featuring both behavioural and neural indices of the sense of agency.


**Keywords:** Social neuroscience
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'EIC Communities: Building Synergies and Communities around EIC Portfolios to raise the impact of the EIC deep tech research' (2021-2027).

assistant: **Innovation**

The project’s main objective is to increase the visibility and impact of EIC portfolios of projects through the co-creation of diverse online and physical activities, materials and tools that will be implemented in  three thematic Communities of Practice - CoP (green, digital/industry/space and health). Those formats will prompt the creation of multidisciplinary communities around selected portfolios, and will stimulate interactions and synergies among projects inside and across thematic and EIC challenge-driven portfolios, while providing the EIC Programme Managers ( EIC PMs) with sustainable measures and community model structures to build  networks around portfolios and develop new visions for future technologies and innovation breakthroughs.  EIC Communities will work closely with the EIC representatives and EIC PMs through, inter alia, co-creation of new engagement practices and co-developing  policy recommendations for R&I in future deep-tech. Community and synergy building activities will be co-developed with CoP stakeholders and implemented inside and across the three CoPs to ensure cross-sectoral and multidisciplinary interactions between EIC open and challenge-driven portfolios and projects. Those activities will include: (i) pitching sessions, (ii) matchmaking between projects, (iii) organisation of Portfolio Days and online interactive academies, (iv) thematic workshops and (v) re-launch of the Future Tech Week. As a result, a wider community, which goes beyond the selected portfolios, will be established in each CoP. The outcomes of the activities carried out in CoPs will be translated in a set of high-impact communication materials that will aim at showcasing the added value of the portfolio ecosystem and benefits stemming from portfolio interactions. Sust
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'INnoVative dEsign of iNstalled airframe componenTs for aircraft nOise Reduction' in the context of a Horizon 2020 call.

assistant: **Objectives**

Mitigating aircraft noise on both modern and future aircraft is a significant challenge for the EU considering the increase of air traffic and extension of urban areas together with the increasing public health concern. Aircraft noise results from the combination of engine noise, significantly reduced after decades of intensive research, and airframe noise, mostly generated by landing gears (LGs) and high-lift devices (HLDs). Strong integration constraints imposed by other considerations than acoustics and our limited knowledge of the complex flow physics mechanisms generating airframe noise have so far limited the development of noise reduction technologies (NRTs) on airframe components such as LGs and HLDs. Direct design of low-noise airframe components based on multi-disciplinary criteria (including acoustics), remains a challenge as well. Therefore, the primary goal of INVENTOR is to better understand the physics of noise generated by LGs and HLDs thanks to intensive use of new, advanced numerical methods. The ultimate goal is to decrease the external noise from business jet and short-medium range transport aircraft through the development of innovative low-noise installed LG and HLD components as well as new promising NRTs, thus contributing to the achievement of the Flightpath 2050 goals pursued by ACARE SRIA on aviation noise. The main Key Performance Indicator in terms of noise reduction will be to lower far-field noise generated by installed LGs and HLDs at landing/approach by respectively 2-3 and 1dB(A). Considering an equal contribution of engine and airframe to noise, we aim to reach an overall gain of about 1 dB(A) on full aircraft extrapolation in approach certification conditions. INVENTOR, gathering 16 partners (RTOs, large industries, SMEs) from 7 EU co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The role of the transcription factor spl in vivo', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content This project aims to elucidate the biological role of the transcription factor Spl. Spl is expressed ubiquitously and it has been implicated in the expression of many different genes (over 1500 publications). Recently, the Spl gene has been inactivated in the mouse (host laboratory). Spl-deficient mice die at day 10 of gestation, showing that Spl is essential for early embryonic development. However, many putative Spl target genes are expressed normally. Additional results suggest that while Spl is dispensable for growth and differentiation of primitive cells, it is required for viability after differentiation. To test this hypothesis, and to study the role of Spl in fully developed tissues, I propose to generate conditionally targeted Spl mice by flanking exons with loxP sites through homologous recombination, after which the Spl gene can be inactivated by Cre recombinase. To obtain tightly controlled and tissue-specific Cre activity, I will use transgenic mice expressing a hormone-dependent version of Cre in different tissues (host laboratory). Thus, I will be able to inactivate the Spl gene in specific tissues at any developmental stage by injection of artificial hormone, in order to study the role of Spl in gene expression and cellular maintenance in these tissues. Training content (objective, benefit and expected impact) In order to carry out this project, I will employ methods like cloning, ES (embryonic stem) cell technology, genetic manipulation of mice, biochemical and immunochemical techniques, as well as state-of-the-art techniques like Representational Difference Analysis (RDA). Links with industly / industrial lelevance (22) None are foreseen at the moment.