RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Catalytic cascade reactions, generic technology for glycobiology' (CASCADECARBOHYDRATES) targeting Sixth Framework.

assistant: **Abstract**

Innovative chemical manipulation of carbohydrates has lagged significantly behind advances in glycobiology (the biochemistry of carbohydrates). Moreover, despite the widespread involvement of carbohydrates in the fundamental processes underpinning human an d animal health and their involvement in the growth and maturation of many of the species responsible for human/animal illness, e.g. bacteria, viruses, there has not been a concerted and substantial involvement of major pharmaceutical /animal health companies in the design and discovery of novel carbohydrate based medicines. A major part of the perceived problems of carbohydrate based drugs are poor pharmacokinetics (PK), high molecular weight, and the accompanying reduced potential for tuning" PK and lack o f compliance with Lipinski's rules. Additionally the need for novel bioprobes to facilitate elucidation of the pathways and mechanisms of important carbohydrate mediated processes continues to grow.For example glycolipids and glycoproteins have key cell surface recognition / adhesion functions in important diseases such as obesity, inflammation, cancer, host-microbial interactions, toxin-receptor interactions etc. Advances are being made in these areas but would be greatly assisted by "tunable" multivalent bioprobes. This project proposes novel catalytic cascade chemistry (multiple sequential reactions of 3,4 or more reactants occurring in "one-pot") of carbohydrates, which delivers products with high diversity and molecular complexity and allows incorporation of important biomolecules such as nucleosidesor lipids as well as the small heterocycles (privileged structures) at the heart of modern drugs. The high regio- and stereo selectivity of the proposed cascades and their ability to provide multivalent assemblies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'HIV and HIV-related opportunistic infections : study of iron chelation'.

assistant: **Innovation**

The progressive tissular accumulation of iron in HIV infection has deleterious consequenses. Therefore more studies are needed on: - mechanisms by which iron and its chelation modulate oxidative stress and HIV-1 replication;- effects of iron-lowering drugs on AIDS-related opportunistic pathogens;- effects of iron chelation in HIV-infected patients.Iron is known to progressively accumulate in several tissues of HIV-infected patients, such as the macrophages. This excessive iron burden leads to an increased oxidative stress, a decreased host defence and a stimulation of the growth of many AIDS-related opportunistic pathogens. The proposed investigors' network will study:1- The mechanisms by which iron or its chelation (by the natural ferritin or by iron chelators) modulates oxidative stress and HIV-1 replication.2- The activities of iron chelators from different classes and of drugs that lower cytosolic iron concentration on AIDS-related opportunistic pathogens from bacterial (Mycobacterium tuberculosis and M. avium), fungal (Cryptococcus neoformans and Candida albicans) and protozoal (Leishmania spp.) origin.3- The effects of iron chelation therapy in HIV-1 infected patients. The first investigation will concern the effects of desferrioxamine on viral load and plasma cytokine patterns; depending on the results of this pilot study, other investigations will follow.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Light driven motion of molecules on surfaces'.

assistant: **Concept**

The relentless drive towards nanoscience and nanotechnology is characteristic of our time. A vital component of the nanotechnology toolbox would be a molecule or molecular assembly that acts as a motor, driving mechanical processes at the molecular level. Ultimately such a miniscule motor can be controlled, be switched on and off, change direction, and move purposefully on a surface. To do all this, the molecule has to perform work and should therefore be able to convert one type of energy into another. One of the ways this energy can be provided would be through light. As we have learned to control and engineer light fields on nanometer length scales on the fast time scales intrinsic to optics this would lead to complete control over the molecular motor. It is not hard to imagine that for the movement of a molecular motor the interaction with the surface and the conformation of the molecule plays a crucial role. For the fabrication and construction processes that must surround the production of working machi nes from molecules it is necessary to obtain a detailed understanding of the chemical and physical properties of these molecules absorbed on a surface. Only with a deeper insight into these properties it is possible to tailor devices to the desired functio nality. In the last years, STM has become one of the most powerful tools to obtain this information by means of high resolution STM images, STS spectra and STM movies of diffusing molecules. It is the purpose of this project to contribute significantly to the understanding of how the motion of large molecules on surfaces can be influenced by light. The approach taken is to excite specific optically induced vibrations in (specifically engineered) molecules and follow their motion in time with STM. By directl y mak
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A panEuropean framework for strengthening Critical Infrastructure resilience to climate change' in the context of a Horizon 2020 call.

assistant: **Objectives**

It is presently acknowledged and scientifically proven than climate related hazards have the potential to substantially affect the lifespan and effectiveness or even destroy of European Critical Infrastructures (CI), particularly the energy, transportation sectors, buildings, marine and water management infrastructure with devastating impacts in EU appraising the social and economic losses. The main strategic objective of EU-CIRCLE is to move towards infrastructure network(s) that is resilient to today’s natural hazards and prepared for the future changing climate. Furthermore, modern infrastructures are inherently interconnected and interdependent systems ; thus extreme events are liable to lead to ‘cascade failures’. EU-CIRCLE’s scope is to derive an innovative framework for supporting the interconnected European Infrastructure’s resilience to climate pressures, supported by an end-to-end modelling environment where new analyses can be added anywhere along the analysis workflow and multiple scientific disciplines can work together to understand interdependencies, validate results, and present findings in a unified manner providing an efficient “Best of Breeds” solution of integrating into a holistic resilience model existing modelling tools and data in a standardised fashion. It, will be open & accessible to all interested parties in the infrastructure resilience business and having a confirmed interest in creating customized and innovative solutions. It will be complemented with a webbased  portal.The design principles, offering transparency and greater flexibility, will allow potential users to introduce fully tailored solutions and infrastructure data, by defining and implementing customised impact assessment models, and use climate / weather data on demand.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'neurAl corRelate for the peRception of Others reWard' under Horizon Europe.

assistant: **Concept**

Perceiving what others feel is one of the most fascinating traits of humans, as social animals. It is believed that sharing emotions is critical to facilitate social coordination, empathic experiences, and prosocial behaviors. Over the past decade, thanks to a groundbreaking emergence of neuroscience tools it has been possible to explore brain activity systematically across humans, primates, and rodents in emotional transfer tasks. Up to date, studies have focused on the transfer of negative emotions such as pain, fear, and distress. Despite the importance of affiliative interactions and perception of positive emotional states from others in shaping how animals behave socially, it is surprising that the transfer of positive emotional states has been virtually unexplored. To fill this gap, I propose ARROW, where I will dissect the neural circuit mechanisms of the perception of others’ positive emotions using a recently developed vicarious reward task for rodents. I will ask how the perception of the rewarding states from conspecifics is implemented at the single neuron level in the Ventral Tegmental Area (VTA), and modulated by long-range neuronal circuits (projections to and from the Anterior Cingulate Cortex). To address this aim, I will build on my previous in vivo electrophysiology skills and leverage on the state-of-the-art expertise of Dr. Márquez in studying social behaviors using quantitative approaches and neural circuit manipulations, and Dr. Charlet in dissecting neuron circuit functionality. This bold and innovative project is not simply incremental but will provide groundbreaking research on a fundamental brain function that is currently understudied. Finally, I will use this funding to catalyze my career as a future influential principal investigator, build
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Using TUnnel Magneto Resistance Technology for MAgnetic POSition Measurement TUMAPOS' (TUMAPOS).

assistant: **Innovation**

BOGEN Electronic GmbH, a German company with a 60 year history, is recognized as a leading magnetic production specialist for information recording and measurement. The aim of this project is to improve BOGEN's position in the magnetic measurement field and increase turnover, create new jobs and increase profit. The project objective is to bring a new magnetic measurement solution to market that will extend the applicability of magnetic measurement in two directions: - Higher accuracy, especially to compete with optical measurement systems with a cheaper magnetic solution - Enter a new business area, where customers request bigger reading distances between scale and sensor The development of the new measurement solution requires three parts: - Improve the TMR elements reading magnetic scales to read the scales at adistance of 4 pole pitches, - Improve the inductive writing methodology to write pole pitches smaller than 25 microns, - Replace the AMR elements in the current sensing heads with the TMR elements and finalize the product With the results of the project, BOGEN can increase the reading distance to for several industries, where the accuracy is secondary to the reading distance. With the increased reading distance, finer pole pitches can be read at a shorter distance. This will provide access to many measuring tasks that can be measured only with optical solutions today and open a market potential of € 600 million. The combination – using TMR and smaller scale increments - will lead to magnetic measurement solutions with higher accuracy at lower cost. During the feasibility study, a TMR based solution was developed and successfully tested. BOGEN has a lot of experience in sensing head design and magnetic scale production, with a patent covering the most effective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Driving Investment in Energy Efficiency through Energy Savings Insurance in Europe 2.0' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The Energy Savings Insurance (ESI) Europe 2.0 project aims to: (i) replicate the successful innovative financing scheme ESI (currently being implemented in Italy, Portugal and Spain with the ESI Europe funded by the EU’s Horizon 2020 research and innovation programme) in three high potential countries in Europe – Croatia, Greece & Slovakia; (ii) hold capacity building, and marketing and promotion activities targeting key market stakeholders to help them understand the model and facilitate access to EE finance; & (iii) to create tools to promote & enable the further replication of ESI across Europe.The ESI model consists of financial & non-financial mechanisms designed to work together to improve the risk-return profile of EE investments & overcome the associated barriers to stimulate the demand for EE projects. It consists of: (i) a standardised contract, which clearly establishes the setup to guarantee energy savings to the SME; (ii) a performance insurance that is used to compensate the SME in case the EE project does not reach the expected energy savings; & (iii) validation mechanisms that provides an independent assessment & verification of the project. These three mechanisms work together to create trust & credibility between actors, & convince SMEs to invest in EE. The model is supported by communications, dissemination & outreach activities, as well as capacity building & EE investment roundtables targeting key market stakeholders, including technology providers with EE solutions, financial institutions, SMEs & others, to create dialogue between the relevant stakeholders & facilitate access to EE finance. The ESI model presents a proven & unique, market based approach that makes use of distribution channels & products that are already available on the market. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Modeling TEL/AML1 childhood lymphoblastic leukemia in zebrafish' to be submitted under Seventh Framework.

assistant: **Abstract**

Acute lymphoblastic leukemia is the most common childhood malignancy and is diagnosed in about 5000 children in Europe every year. The most frequent B-type acute lymphoblastic leukemia, called TEL/AML1, is due to a chromosomal translocation that results in the fusion of two transcription factors, TEL with AML1 (also called RUNX1). Most treatments of TEL/AML1 acute lymphoblastic leukemia result in a good outcome, although some patients suffer very late relapse which cannot be anticipated at the diagnosis. Anticipating and treating the late relapse is a real therapeutic challenge.Understanding the pathogenesis of TEL/AML1 will allow anticipating the late relapse and proposing adjusted therapy and new targeted therapy.TEL/AML1 translocation leads to increased expression of the normal allele of AML1. AML1 is a major transcription factor for hematopoiesis. AML1 impairments are found in many acute leukemia: lymphoblastic, myeloid, and megakaryoblastic. Finally, amplifications of AML1 in other B- acute lymphoblastic leukemia are suspected to worthen the prognosis.My goal is to address the question of TEL/AML1-associated leukemogenesis by characterizing the cooperation between AML1 and TEL/AML1 in an innovative pathophysiology approach. We will combine molecular and cellular biology approaches with physiological approach in zebrafish, and validation in human samples. We will use TEL/AML1 transgenic zebrafish that is the only model of TEL/AML1 leukemia available. We will focus on studying the rate of onset of leukemia, change in proliferation, survival and differentiation of lymphoblasts in dual transgenic TEL/AML1 and AML1 zebrafish. We will validate the results in a large cohort of human TEL/AML1 pre-B acute lymphoblastic leukemia samples.This study will provide new insights o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sharing knowledge in e-Health Information Systems - a semantic interoperability RTD roadmap' in the context of a Sixth Framework call.

assistant: **Objectives**

To efficiently implement e-Health to meet the rising needs of mobile citizens, patients and providers, the fragmented interoperability initiatives now distributed throughout different EU and Member State (MS) programmes must come together.They must be coordinated with the increasing need to link clinical data to information from basic biological sciences and evidence of best clinical practice. Considering the need for interoperability at the MS and cross-border level of the EU - as expressed in the EU e-Health Action Plan - and for global interoperability - as represented by WHO - it is necessary to embark on a process that will prompt the divergent initiatives to join forces for the benefit of all citizens.This SemanticHEALTH SSA develops a European and global roadmap for research in health-ICT, focusing on semantic interoperability issues of e-Health systems and infrastructures. The roadmap will be based on consensus of the research community, and validated by stakeholders, industry and MS health authorities.It- identifies key short-term (2-5 years) and medium-term (4-10 years) research needs to achieve semantic interoperability of e-Health systems (including issues of nomenclatures presently in use, classifications, terminologies, ontologies, EHR and messaging models, public health and secondary uses, and decision support, their relationships, mapping needs, limitations)- analyses unsolved research issues arising in the context of realistic approaches to priority clinical and public health settings (reflecting on models of use, benefits expected, concrete application experience and lessons learned; relevance of open source model)- takes account of the impact of non-technological (health policy, legal, socio-economic) aspects- reflects and integrates results of relate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Biomarkers: the early warning sentinel of chemical pollution risk assessment'.

assistant: **Concept**

Nowadays the risk assessment of chemical pollutions is considered essential to be evaluated on measurement of the biological effects and not only on chemical analysis of environmental samples because this approach does not provide any indication of deleterious effects on living organisms. To this demand, recently the biological markers, or biomarkers which can be defined as indicator of normal physiology alteration, emerged as extremely important to monitor the pollutant impact as well as to assess the toxic effects on the environmental health. Further, new technologies mainly based on post genomic era, which combine the studies of the gene expression at level of mRNA and protein highlighted more and more questions related to the concept of the risk assessment as well as the definition of safety margin of a chemical in the environment. In this scenario, our project proposes a new method based mainly on a very sensitive technique to monitor the effects of pollutants at transcription level (mRNA) of known biomarkers. For this purpose, two biological models will be exposed to different concentrations of marine pollutants (i.e. heavy metals and organic compound) and the known biomarkers (i.e. Metallothionein, Cytochrome P450) will be analysed at level of mRNA transcription using the Real Time Quantitative PCR (Q-PCR), which allows to detect very small changes at level of mRNA expression. Our attention will be focused on two crucial concentrations of pollutants, the one that so far is considered according to the European policies; the dose without any toxic effect and it is probably that our method could already detect an effect at molecular level. The other concentration will be used to study the so called  chronic effect" of a compound. A very low dose effect will be analy