RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nanosystems for the early Diagnosis of Neurodegenerative diseases' (NADINE).

assistant: **Innovation**

Medical diagnosis is currently undergoing a major revolution due to the fast discovery of molecular biomarkers, and the development of multimodal “metabiomarker” signatures. Progress, however, is hindered by low abundance of many biomarkers of interest in body fluids, in absolute concentration and with regard to other biomolecules. The aim of the present project is to apply these progresses in biotechnology, nanoparticle synthesis, and nano-instrumentation to the development of fully integrated lab-on chip instruments able to perform elaborate multimodal biomarker analysis on a routine basis and at the ultrasensitive level required to allow minimally invasive tests. In particular, we aim at overcoming a major bottleneck on the path to this objective, which was identified in a previous project in the “HEALTH” priority: no satisfactory solution currently exists to bridge the several orders of magnitude between the nanoscale volumes at which ultrasensitive new generation sensors operate, and the often millilitre volumes of samples in which the molecules of interest must be found. For this, we shall combine innovations in pre-concentration, micro and nanofluidics, self-assembly, micro-nanofabrication, and nanodetection. The project will develop a generic, multipurpose, platform of compatible enabling technologies, and integrate them into devices. In order to maximize impact and societal benefit, the project will be validated on an application of major interest for health, namely the early detection of biomarkers for neurodegenerative diseases (including Alzheimer), with special emphasis on subtyping of these diseases for improved treatment strategies. The consortium includes a multidisciplinary group of technology developers, three leading biomedical groups in clinical neur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'UA NCP FOR DEEPER INTEGRATION OF UKRAINIAN RESEARCHERS TO EURATOM' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The Association Agreement between Ukraine and Euratom was signed on 27 June 2016 and entered into force on 28 October 2016. Better integration of Ukrainian nuclear research entities into European nuclear research networks could be seen as mutually beneficial for the whole Euratom research community.“UA NCP for deeper integration of Ukrainian researchers to Euratom” project (Acronym: UAinEuratom) is initiated in order to provide deeper integration and improved participation of Ukrainian researchers and research entities in Euratom research activities with future aim to increase their participation in Euratom projects, thereby enabling a more broad and effective cooperation in the field of research on fission and fusion, and fully exploiting the potential of Ukrainian research entities regarding their infrastructures, capacities and research programmes.NSC KIPT was officially appointed by the Ukrainian authorities as National Contact Point to Euratom in 2017. UAinEuratom is an 18 months project that is initiated as support and coordination action for the NCP to Euratom in Ukraine (UA Euratom NCP) to integrate Ukrainian researchers and research centers to Euratom.UAinEuratom project specific objectivesUAinEuratom project has the following specific objectives:•Strengthening of UA scientists participation to Euratom programmes;•Enhancing of Ukrainian - EU networking activities in Euratom research area;•Raising of Euratom programme awareness among representatives of Ukrainian research centers, SMEs, authorities and strengthening the link between Euratom and Ukrainian science communities;There are four work packages that include all project activities to achieve the objectives. All work packages will be managed and implemented by KIPT (Ukraine).•WP1. UA Euratom NCP skills and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Real-time Evaluation and Classification of Plastics'.

assistant: **Objectives**

The Virtual Chemist is a quality analysis machine used within the plastic recycling chain, based on artificial intelligence. This project aims to increase the accuracy of this analysis through the implementation of new, state-of-the-art AI architectures and by using real-time data for further optimization. This proposal calls for a help for a new research associative to help drive this innovation faster and more efficient, thus enabling high accuracy classification algorithms. These algorithms would  enable the plastic recycling industry to increase recycling rates while creating a quality recycled material that can be used in new high-grade applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Process improvement based on PSP' (PIBOP) under Fourth Framework.

assistant: **Objectives**

INTRACOM's main business concern is to provide reliable and safe products as well as to improve its market competitiveness. To the satisfaction of this common business concern, the objective of the PIBOP experiment is to introduce W.H. Humphrey's Personal Software Process (PSP) method at INTRACOM S.A. This method, focusing on the individual software engineer level, allows for systematic implementation of proven practices on planning, tracking and analysis of software design work and products.THE EXPERIMENTThe PIBOP experiment will introduce the PSP method at INTRACOM, focusing on a typical project as a baseline. The initial step of the PIBOP PIE is the setting-up and integration of the experiment within a typical baseline project. Then, introduction and training on the PSP method is carried out, and the specific adaptation procedures for the baseline project are documented. The PSP will be executed throughout the baseline project and the PIE results will be evaluated based on appropriate measurements. The four main phases of the experiment are: PSP introduction, PSP adaptation, PSP execution and PSP evaluation. The baseline project involves development of software modules for AXE-10 Ericsson digital exchanges. The duration of the baseline project will be 12 months and the estimated effort will be 8 person-years.The PIBOP experiment will take place at INTRACOM's Software Design Centre which employs 180 highly qualified software engineers.EXPECTED IMPACT AND EXPERIENCETechnical benefits from PIBOP include: identification of process improvements, prevention of defects in software development, better planning and control in projects and improved product quality. Commercial benefits include: reduction of software development cost, shortening of the time-to-market for softwar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Early Medieval Glosses And The Question Of Their Genesis: A Case Study On The Vienna Bede' (GLOSS-VIBE) targeting Horizon 2020.

assistant: **Abstract**

The early medieval period is marked by constant interchange and multicultural relationships, and has significantly shaped Western intellectual history. During this time Irish scholars started to annotate texts, i.e. underlining, highlighting, glossing etc. – techniques that quickly spread across the European continent and are still used today. Gloss-ViBe will research the early medieval Celtic glossing tradition on the Venerable Bede’s De Temporum Ratione. Its main research question is: “Are vernacular glosses original compositions or translations from original Latin glosses?” The present project will investigate the Celtic and Latin glosses found in the manuscript Vienna, Österreichische Nationalbibliothek, Codex 15298 (olim Suppl. 2698) from different angles including methodology from the digital humanities, philology, linguistics and translational studies. Since there is a lack of comprehensive editions of early medieval glossed manuscripts, this study is a pioneering and challenging task. One of its main deliverables will be the first such comprehensive digital documentary edition. It will include the primary text and all the glosses and annotations found in the Vienna Bede.  Because of the fragile nature of the manuscript and recent advances in digital humanities in conjecture with a simultaneously arising interest on how to annotate (digital) documents caused by the recent shift from paper to digital media, the proposed research is highly topical at this time. It offers insights into how information has been processed that can be directly applied to modern annotation systems. Additionally, researching the multicultural environment in which early medieval manuscripts were composed also has impact for understanding modern migration patterns, especially in a scholarl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Enabling Catalytic Cross Couplings with only Zinc Electrophiles, Nucleophiles and Boranes'.

assistant: **Objectives**

This high-impact, challenging CoG Proposal integrates multiple novel ideas in boron and zinc chemistry into an overarching project to open up new horizons across synthesis and catalysis. The Applicant’s successful ERC StG has opened up new avenues of pioneering research in main group element mediated transformations that were not conceivable before the work was done. Components of this proposal extend out from the StG into new, exciting research areas that are completely different. Developing low toxicity earth abundant catalysts for important transformations is vital to the EU with the focus herein being on; (i) the Suzuki-Miyaura (S-M) cross coupling reaction which is ubiquitous in industry and academia, and (ii) the formation of organoboranes that are essential synthetic intermediates. Both of these are currently dominated by toxic, expensive and low abundance precious metal catalysts (e.g. Pd, Ir). This project will deliver innovation through utilising combinations of main group Lewis acids and nucleophilic anions that do not react with each other, i.e. are frustrated pairs. This “frustration” enables the two species to concertedly transform substrates to achieve:(i) precious metal-free S-M cross coupling reactions of sp3C electrophiles catalysed by zinc and boron compounds, including stereospecific couplings and one pot two step cross electrophile couplings(ii) trans-elementoboration of alkynes, including the unprecedented fluoroboration of alkynesOther new approaches will be developed to access novel (hetero)arylboronic acid derivatives using only simple boranes and without requiring noble metal catalysts, specifically: (i) boron directed C-H borylation and (ii) directed ortho borylation to enable subsequent meta selective SEAr C-H functionalisation. This CoG will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A fire-resistant, thermal and acoustic insulating lightweight fabric'.

assistant: **Concept**

The global market for technical textiles grows rapidly. It is accompanied by increasing customer needs and stricterregulations combined with the demand for lower prices. This is especially true for high-value markets such as automotiveinsulation, thermal protective clothing or hot gas filtration. Even though these segments appear to be quite different, themajor needs are very similar: higher safety (thermal insulation, flame resistance), higher comfort (lightweight, acousticinsulation, filtration efficiency), better processability, lower price. As current solutions cannot fulfil these high demands andregulations, this represents an excellent opportunity for smartMELAMINE. By enabling thermoplastic processing of melaminein a dedicated meltblown process, it is possible to create a fabric with unmatched fibre fineness and a unique set ofproperties at costs well below competitive solutions. The project is based on a thorough business plan. In talks with morethan 100 potential customers, the need for new solutions has been emphasized and a high interest in smartMELAMINE wasconfirmed. Samples at pilot-scale (width: 300mm) have been produced on a continuously updated pilot plant and tests in anindustrial environment have confirmed the processability of the melamine-meltblown at larger scale (TRL6-7). The mainobjective of the phase 2 project is the upscaling of the production process to industrial scale (2,400mm) and the furtherimprovement of fibre fineness and volume weight, in order to perfectly address the market needs. The partners combineunique know-how regarding melamine processing and meltblown technology. The joint venture SML will build on this know-how to facilitate the commercialisation of smartMELAMINE. Unlimited licenses and patents guarantee the freedom tooperate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Extended studies into the molecular pathogenesis of Congenital Adrenal Hyperplasia - towards novel therapeutic approaches' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Congenital Adrenal Hyperplasia (CAH) ranks amongst the most common inherited metabolic diseases. It comprises a group of autosomal recessive disorders caused by mutations in genes encoding enzymes involved in steroid synthesis. Two key enzymes are the cytochrome P450 (CYP) type II enzymes 21-hydroxylase (CYP21A2) and 17α-hydroxylase (CYP17A1), both requiring electron transfer from the electron donor enzyme P450 oxidoreductase (POR). Functional analysis of CAH-causing mutations currently consists only of in vitro enzyme activity assays that do not address other and potentially very important molecular aspects such as protein folding and enzyme-cofactor dimerisation. Incorrect protein folding may lead to endoplasmic reticulum (ER) stress, which plays an important role in the pathogenesis of various diseases, e.g. diabetes mellitus. The first aim of the proposed project is to systematically analyse mutations in CYP21A2, CYP17A1 and POR by not only studying residual in vitro activity, but also by dissecting the mutations’ effects on protein stability and protein degradation. Subsequent studies will establish the potentially therapeutic role of small molecules (pharmacological chaperones, proteostasis regulators) in refolding and restoration of enzyme function of CYP21A2, CYP17A1 and POR enzymes. Secondly, this project will characterise the ER localisation and interactions of the CYP21A2, CYP17A1 and POR proteins, including dimer-formation. These data will provide essential insights into functional and structural in vivo topology of steroidogenic enzymes. This will lead to a better understanding of molecular mechanisms involved in steroidogenesis. In conclusion, this highly innovative project will apply novel strategies to study and to potentially restore steroidogenic enzym
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SOlar Energy to power CO2 REduction towards C2 chemicals for energy storage' (SOREC2).

assistant: **Concept**

SOREC2 aims at developing a breakthrough technology for a direct transformation of sunlight and CO2 into chemicals, such as ethanol or ethylene, for a safe energy storage. SOREC2 brings expertise in photonic structure design (for optimal sunlight harvesting) together with expertise in catalysis (to reduce CO2 into products that can store chemical energy or with a high economical interest). On the light harvesting side, ICFO will develop a system composed of three complementary light-absorbing elements in order to obtain the largest possible broadband sunlight harvesting. This system will rely on newly developed light trapping nano-configurations and will enable fine tuning of the potential energy needed for the reduction reactions via an innovative arrangement of the low, middle and high bandgap materials. CALTECH will develop a hybrid catalyst system, exploiting a novel combination of CO2 reduction catalysts with a redox/proton mediator to lower overpotentials and enhance selectivity towards C2 products such as ethanol or ethylene. For the photoanode, where the chemistry and the optics in a photoelectrochemical cell (PEC) are interwoven, UAB and ICFO will design a multilayer configuration to achieve an optimal electro-chemistry, while not undermining the optical performance of such PEC. To ensure a transformation of the scientific research into a technology breakthrough with substantial economical and societal impacts, SOREC2 incorporates UNIFE to define the PEC upscaling roadmap and the companies GEM, SAULE, and VITSOLC for the creation of new markets. Finally, to identify non-technical barriers (such as political, economic, and societal) that SOREC2 may encounter, and to engage relevant stakeholders and citizens on the route towards market uptake, SOREC2 incorporates
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development and use of Cell Cultures for Commercially Important Aquatic Invertebrates.' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Farmed crustacea and mollusca account for approximately 60% of the worlds consumption of these groups. The organisms represent high value (in economic terms), and are very important to the economies of France, Portugal, and the Far East. Production is likely to increase substantially over the next ten years. Yet, production is blighted by disease and lack of understanding of physiology, leading to high economic losses. This project addressing some of the fundamental issues regarding the biology and pathology of species of commercially important invertebrates. In particular, the development of cell lines will have an immediate impact on the ability to study viruses diseases, which are often suspected to occur but which cannot be confirmed in laboratory studies. Also, well-characterised cell lines will enable the study of exotoxicology, pathology, and disease-control, such as by vaccination. Basic biological aspects, such as the development of monoclonal antibodies, will enable the proper characterisation and screening of species and tissues.By specifically studying growth factors, e.g. hormones and vitamins, it will be possible to identify growth limiting substances of relevance to whole animal nutrition.Methods and preliminary resultsThis project which is a concerted action has just commenced (December 1997) and an inventory of methods available in member laboratories has been compiled. The main techniques use explanted tissue fragments, which are cultured in commercially available media with the osmolarity increased to facilitate culture of marine invertebrate cells. Tissues being investigated at present include Crustacean (Nephrops) gill and hepatopancreas, crustacean (Nephrops and Cancer ) hypodermis and molluscean (Ostrea ) heart . Specific techniques may be made av