RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Studies of the fo membrane sector of atp synthase from escherichia coli' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

ATP synthase (F1F0- ATPase) is the central enzyme in energy conversion in mitochondria, chloroplasts and bacteria, driving the synthesis of ATP from ADP and inorganic phosphate. This multisubunit assembly consists of a globular domain, Fl (A group led by Dr.Walker has already determined the structure of F1-ATPase from bovine heart mitochondria), linked to an intrinsic membrane domain, F0. The long term aim is to establish the structure of the F0 membrane domain using the enzyme from E.coli. The simplest known F0 is found in E.coli. It consists of three subunits a","b" and "c" (a1b2c9-12). Subunits "a" and "e" are hydrophobic membrane proteins. Subunit "b" is a highly charged hydrophilic protein, which is thought to act as a central component in the interactions with F,. Over-expression of subunits "c" and "b" individually has been achieved, but neither F0 nor subunit "a" alone has yet been expressed successfully. The basis of the inestabitity will be first investigated, and once the problem has been overcome, the complex will be reconstituted. This will then permit the sites of interaction between the three subunits to be studied by mutation and cross-linking, and it will provide F0 for crystallization trials. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'NOVEL COMBINATIONS OF NATURAL ANTIMICROBIAL SYSTEMS FOR THE IMPROVEMENT OF QUALITY OF AGRO-INDUSTRIAL PRODUCTS' to be submitted under Fourth Framework.

assistant: **Abstract**

The principal objective of this project will be to improve the quality of agro-industrial products (especially but not exclusively food products) by applying low levels of novel natural antimicrobial systems in combination with reduced levels of traditional physical and chemical food preservation processes.The work will address the effects of new natural food preservatives such as bacteriocins, enzymes, chitosan, herbs, spices etc. in combination with milder forms of traditional preservation systems such as pasteurization, refrigeration, acids, benzoates, sulphites etc. on pathogenic and spoilage organisms in foods and associated with food processing. The ecological interactions of microorganisms with each other and with the components of foods (proteins, carbohydrates, fats, etc.) will form an important aspect of this work. The maintenance and/or improvement of the sensorial as well as microbial quality of food products will be of paramount importance. The food products selected for study will include fresh sausages, pate,cured meat products (ham and bacon), low-fat cheese spread, lowsugar preserves, beer, salads and fruit and vegetables (fresh and minimally processed). There will be an element of predictive microbiology using mathematical modelling techniques.The potential for replacing chemical biocides used for cleaning of industrial surfaces with novel natural antimicrobial compounds will be investigated. The usefulness of natural antimicrobial compounds in non-food applications such as cut flowers will alsobe studied. Any potential toxicological consequences of novel antimicrobial compounds will be tested. Finally, novel extraction methods and enzymic upgrading techniques will be investigated in an attempt to extend the utility of selected existing and novel natur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'An innovative platform for tomorrow's cars' to be submitted under Fourth Framework.

assistant: **Abstract**

The objectives of this research are to use the advantages of aluminium honeycomb panels developed in the aeronautic sector in the automotive sector, for the development of a platform (the structural part supporting the engine and body of the vehicle) using welding techniques to meet a three-points challenge: A. a 15% gain in weight compared to other panels B. to pass European Safety Norms EUR03-93 C. low costs of production for SMI's To achieve these objectives, the R&D programme will: 1. work on the optimisation of the processing of welded aluminium based honeycomb for increased mechanical strength and durability. 2. work on the optimisation of platform design for crash resistance 3. use numerical simulation of crash and crash tests for validation of platform prototypes In accordance to the CRAFT programme, the goal of the companies involved in this cooperative research is, through the development of this platform, to make possible the arrival of a new generation of economic, flexible, safe, environmental friendly vehicles for low volume production. to respond to growing demand for tomorrow's transportation means (e.g. urban automated people movers, electrical cars ) . The main expected impacts of such a technical innovation are: - environmental friendly vehicles with lower pollution levels - more affordable flexible, urban and leisure vehicles in accordance to the new European life style - the creation of direct and indirect employment in the composites, parts and automobile industries
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Stable high hydrogen low NOx combustion in full scale gas turbine combustor at high firing temperatures', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Nowadays, the increasing awareness of the need to decarbonise the economy has put pressure on the power generation sector to reduce their share CO2 emissions. In this context, gas turbines are the most robust, mature, and cost-effective technology especially for large-scale power generation. A convenient approach to decarbonise the fuel of gas turbines is to mix natural gas with increasingly amounts of hydrogen. As such, it becomes essential although challenging for gas turbines to operate any mixture of natural gas and hydrogen. HELIOS will develop the needed technology for hydrogen combustion as a retrofit solution based on the FlameSheet™ combustor. Essential for this approach is a sound fundamental understanding of hydrogen combustion, combined with advanced numerical modelling techniques and measurement techniques of hydrogen combustion in a full-size combustor. This is essential to boost the required technological developments for utilization of hydrogen-enriched natural gas with the FlameSheet™ combustor. The HELIOS project will start at the gas-turbine testing using the FlameSheet™ combustor at well-defined lab conditions (TRL 4) and will reach realistic conditions in a relevant environment (TRL 6) by the end of the project. Besides the technical developments, HELIOS will stimulate the emergence of an immense innovative ecosystem and create a fertile ground for future up-take of this technology at larger scale. This becomes more and more relevant since GTs are one of the few options to generate high amounts of energy that are needed to compensate a grid that heavily relies on Renewable Energy Sources (RES) due to fluctuating wind and solar electricity supply. This HELIOS concept has the potential to contribute significantly to solving substantial challenges that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Lines of exclusion as arenas of co-operation: reconfiguring the external boundaries of Europe -- policies, practices, perceptions' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Assuming that the development of cross-border interaction mechanisms is a vital element in dealing with the political and socio-economic challenges of EU expansion, EXLINEA examines opportunities and constraints to local/regional cross- border co-operation in CEE. State borders are viewed as socio-political constructs whilst cross-border region building is conceptualised as a process of formal and informal integration conditioned by overlying policies, co-operation practices and perceptions of the significance of cross-border interaction.The research questions (applied to 6 case studies) include:1) how do EU and national policies regulating the permeability of borders influence local cross-border co- operation patterns,2) what specific formal and informal co-operation practices have developed and why,3) what have been the national, regional and local responses to EU border policies in specific border region contexts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Quantum Simulation on a Photonic Chip' to be submitted under Horizon 2020.

assistant: **Abstract**

Simulation is a fundamental computational tool for modern science with applications ranging from drug design to materials science. Quantum simulators have the potential to revolutionize the way simulations are performed by accessing system sizes that are untractable in classical machines. As a result, they will become a suite of powerful and precise instruments enabling the investigation of relevant phenomena in the dynamics of complex quantum systems, such as quantum transport and energy transfer, as well as implementing quantum improved computation -  tasks hard to simulate classically. QUCHIP aims at implementing quantum simulation on integrated photonic processors. Photons present unique advantages deriving from their mobility and the immunity to decoherence: these two features make them substantially different from any other quantum system. Moreover integrated quantum photonics capitalizes on the multi-billion dollar investment already placed into photonics development and commercialization. QUCHIP will exploit these advantages to implement quantum walk experiments in which several photons propagate over complex circuit architectures “jumping” between different waveguides. This platform represents the most resource-efficient quantum computation scheme to date: Boson Sampling. Recent computational theory findings have shown exceptional potential for this scheme to achieve the quantum supremacy regime in which quantum systems surpass classical ones. QUCHIP will develop new photonic technologies, ranging from on-chip sources of single photons to complex waveguide architectures and on-chip detectors. We will explore the dynamics of noisy quantum networks and develop practical schemes to demonstrate key structural and functional elements of the network dynamics. The ben
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Processing and control of novel nanomaterials in packaging, automotive and solar panel processing lines' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Nanocomposites are promising for many sectors, as they can make polymers stronger, less water and gas permeable, tune surface properties, add functionalities such as antimicrobial effects. In spite of intensive research activities, significant efforts are still needed to deploy the full potential of nanotechnology in the industry. The main challenge is still obtaining a proper nanostructuring of the nanoparticles, especially when transferring it to industrial scale, further improvements are clearly needed in terms of processing and control.The OptiNanoPro project will develop different approaches for the introduction of nanotechnology into packaging, automotive and photovoltaic materials production lines. In particular, the project will focus on the development and industrial integration of tailored online dispersion and monitoring systems to ensure a constant quality of delivered materials. In terms of improved functionalities, nanotechnology can provide packaging with improved barrier properties as well as repellent properties resulting in easy-to-empty features that will on the one hand reduce wastes at consumer level and, on the other hand, improve their acceptability by recyclers. Likewise, solar panels can be self-cleaning to increase their effectiveness and extend the period between their maintenance and their lifetime by filtering UV light leading to material weathering. In the automotive sector, lightweight parts can be obtained for greater fuel efficiency.To this end, a group of end-user industries from Europe covering the supply and value chain of the 3 target sectors and using a range of converting processes such as coating and lamination, compounding, injection/co-injection and electrospray nanodeposition, supported by selected RTDs and number of technologi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Generation of asymmetry in mitotic exit network (MEN) signaling' (MEN).

assistant: **Innovation**

The mitotic exit network (MEN) is a signaling pathway that promotes exit from mitosis in Saccharomyces cerevisiae by maintaining the protein phosphatase Cdc14 released from the nucleolus into the nucleus and the cytoplasm, where it eventually promotes mitotic cyclin degradation. MEN resembles a RAS-like signaling cascade. The GTPase Tem1 and the two component GTPase-activating protein Bfa1-Bub2, which function at the top of the MEN, have been shown to localize only to the spindle pole body (SPB, the yeast’s centrosome) that enters the daughter cell during anaphase, while they are excluded from the SPB that stays in the mother cell. Based on our observations, the differential localization of Bfa1, Bub2, and Tem1 to SPBs is determined by a different efficiency in loading of the complex onto the SPBs that is dependent on specific microtubule-cortex interactions. We have also found that polarization of the actin cytoskeleton plays an important role in the generation of the asymmetry. However, the determinants of this asymmetry and the exact mechanism are still unknown. The objectives of this proposal are to: (i) Evaluate the role played on this asymmetry by proteins that either interact with the Tem1 complex or involved in other processes of generation of polarity; (ii) Perform genetic screens to identify genes required for the asymmetric localization of Bfa1, Bub2 and Tem1; (iii) Identify the regions within Bfa1, Bub2 and Tem1 that are necessary for their localization and for the generation of the asymmetry; (iv) Examine the consequences of disrupting the asymmetry in the Tem1 complex localization on the progression through the cell cycle. Answering these questions will increase our knowledge about the regulation of the exit from mitosis and the mechanisms that control the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Protein complex purification by in vivo biotinylation' under Sixth Framework.

assistant: **Concept**

Novel methodology involving the specific in vivo biotinylation of tagged proteins in mammalian cells has been developed. The proposed project entails the application of this methodology as a one step high affinity approach in purifying novel protein complexes of the hybrid proteins formed from translocations in Chronic MyeloProliferative Disorders (CMPDs).The CMPDs, a category of leukaemias, are characterized by uncontrolled proliferation of one or several cell types of the myeloid or haematopoietic lineages. Translocations found in CMPDs create hybrid genes, producing hybrid proteins functioning as activated tyrosine kinases that trigger the uncontrolled cell proliferation. The proposed project will focus on the purification of complexes of two such hybrid proteins: BCR-FGFR1 and BCR-PDGFRA.A bio-tag will be fused to the specific proteins and will be co-expressed in mammalian cells with a bacterial biotin transferase, which recognises and specifically biotinylates the tagged protein. Complexes of biotinylated proteins will be purified by binding to streptavidin and bound proteins will be eluted and identified by mass spectrometry. This project will elucidate the molecular mechanisms causing the CMPDs and will provide insights in the field of proteomics for these disorders.The future goal will be to translate this knowledge into new strategies for clinical management, at both the diagnostic and therapeutic level (i.e. identification of novel inhibitors of the proteins identified for treatment of CMPDs and potential siRNAs assays to inhibit the hybrid proteins or their partners).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovation relay centre Luxembourg trier saarland proposal for period 2004-2008' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Geographical Area: Grand-Duchy of Luxembourg (L) - Region of Trier (D) - Saarland (D) Strategic Objectives On the basis of the experiences achieved during its activities under FP4 and FP5, the trans-national Innovation Relay Centre Luxembourg-Trier-Saarlan d (IRC-LTS) has become the regional platform for supporting European technology co-operation and international technology transfers. According to European and regional policy objectives, the IRC-LTS will support its customers by providing a full service re lated to trans-national innovation activities by: - Providing advice and assistance in terms of generating trans-national technology transfer agreements - Promoting trans-national initiatives and IRC network services and events - Stimulating the capacity o f firms to adopt new technologies - Making use of European R&D results By carrying out these IRC services, the consortium ensures an increase in the openness and competitiveness of companies and a reinforcement of the link between research and industry at a European level. The IRC-LTS clearly understands the indispensable presence of the IRC network for regional companies and therefore plays a role of intensive co-operation not only with all other IRC's but also with other related European networks. Spe cial attention will be placed on key topics in order to raise the quality and attractiveness of the services: - Increasing the customer relationship management approach in order to facilitate follow-up and the knowledge management - Increasing the use of n etworking and best practice exchange, especially with the neighbouring IRC's - Links with other services and/or networks such as ESA and EUREKA - Use of a clustering approach on specific thematics Thanks to its highly experienced and multi disciplinary tea m, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quality-of-Experience Improvement for Mobile Multimedia across Heterogeneous Wireless Networks' under Seventh Framework.

assistant: **Concept**

With the rapid innovation in sophisticated wireless communication technologies, the past years have witnessed a dramatic growth of content-rich and resource-hungry mobile multimedia applications that demand high Quality-of-Experience (QoE). The overall objective of this project is to bring together a highly qualified group of researchers from both European countries and China to explore the strategies for QoE improvement of mobile multimedia across heterogeneous wireless networks. Built upon the solid ground of cooperation and knowledge transfer between the partners, this project will be unique in its advocate of the seamless integration of network-aware adaptive multimedia processing at the application layer and multimedia-driven heterogeneous wireless networking at the transmission layer. The optimal interaction through a cross-layer design plays an important role in efficient utilization of scarce wireless communication resources to deliver mobile multimedia and improve the users perceived QoE with the aim of creating a new era where multimedia service providers, network operators and end users all benefit.The techniques to be developed will fill important gaps in the fundamental understanding of QoE-improved wireless multimedia communications and provide the theoretical underpinning for system design and algorithm implementation. By strengthening the mobility of European and Chinese researchers, the project will bring new blood and ideas into the academic research of both regions. Moreover, this staff exchange programme will help to cross-fertilise and exchange ideas in order to accelerate the development and knowledge transfer of wireless multimedia networks, set up future joint research projects, and build up long-term world-class collaboration. This project will