RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Environmental factors, helicobacter pylori infection, genetic suceptibility and the gastric cancer risk in the european population (EUR-GAST)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Helicobacter pylori (Hp) infection is an important cause of gastric cancer (GC), duodenal and gastric ulcer, and gastric lymphoma. Factors affecting progression, pathways and outcomes of this process are not known. Vegetables and fruits are associated with GC, but the mechanism of action remains unknown. Role of nutrients, alcohol and tobacco has not been established. Genetic susceptibility may influence individual responses to these factors explaining why only a minority infected persons developed GC. In a multicenter prospective study carried out in nine European countries, a nested case-control study will be conducted aimed to elucidate the individual and joint effects of Hp infection, genetic polymorphisms, nutritional status and environmental factors putatively involved in the aetiology of GC in the European population.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The evolution of cis and trans-regulators in eukaryotes' (RegEvol) under Horizon Europe.

assistant: **Objectives**

Gene regulation plays an essential role in shaping species differences and modulating phenotypes across development and environmental conditions. It essentially works through the recruitment of trans-acting intermediates to cis-acting DNA sequences affecting the expression of the nearby gene. While gene expression regulation is central in molecular, cellular, developmental, and system biology, its detailed mechanisms have relatively little been incorporated into modern evolutionary theory. I previously discovered two processes specific to gene expression evolution in diploids, cis-regulator runaway and divergence. They arise because of (i) transient dominance modifications that automatically occur following the evolution of cis-acting regulatory elements and (ii) coevolution of these cis-acting elements with trans-acting regulators. I have shown that accounting for these processes calls into question a half-century of theory on sex chromosome evolution and may rejuvenate empirical and theoretical work in this field. Here, I will develop the evolutionary theory of cis- and trans-regulators at full scale and empirically test its core features and predictions. Specifically, there are sound reasons to believe that this new theory also has the potential to strongly advance our understanding of other fundamental and enigmatic features of eukaryotic life. It may be a crucial missing element to explain the origin of eukaryotic regulatory complexity and how and why sex  asex transitions fail or succeed and, therefore, why eukaryotic sex is maintained. RegEvol offers a new and original approach to important problems in evolutionary biology. If successful, it will significantly advance our understanding of eukaryotic life-forms and provide a general framework for gene expression e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Improving European aquaculture by advancing selective breeding to the next level for the six main finfish species' (FISHBOOST).

assistant: **Concept**

Only about 10% of today’s global aquaculture production use genetically improved stocks. In Europe, some breeding programmes consist of only the basic components of a breeding scheme. Hence, there is large potential to increase efficiency and profit by domestication and genetic improvement of farmed finfish. The main challenge of FISHBOOST is to realise this potential into economic and social acceptable breeding schemes, and advance these for each of the six target species. Acknowledging the different capacities of the species, the aim of FISHBOOST is: To improve the efficiency and profitability of European aquaculture by advancing selective breeding to the next level for each of the six main finfish species through collaborative research with industry. FISHBOOST considers the main components of breeding programmes for Atlantic salmon, common carp, European seabass, gilthead seabream, rainbow trout and turbot. Disease resistance and production efficiency are genetically improved through detailed phenotyping and advanced genomic technologies. The economic impact and producers’ perceptions will be assessed for the recommendations for each of the species. 14 well-recognised RTD participants in Europe on aquaculture breeding will collaborate in a five year comprehensive research project with 7 SMEs, 4 large industries and 1 NGO throughout Europe that are in the lead of the development of their species’ breeding programmes or are vectors between industry and RTD. A mixture of low and high-tech technological advances depending on current capacities of the species will be developed to move each species’ breeding program to the next level. This step-change advance will facilitate balanced and sustainable breeding programmes applying a wide set of traits, breeding tools and tech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Frontiers of Quantum Atom-Light Interactions'.

assistant: **Innovation**

FoQAL aims to completely re-define our ability to control light-matter interactions at the quantum level. This potential revolution will make use of cold atoms interfaced with nanophotonic systems, exploiting unique features such as control over the dimensionality and dispersion of light, the engineering of quantum vacuum forces, and strong optical fields and forces associated with light confined to the nanoscale. We will develop powerful and fundamentally new paradigms for atomic trapping, tailoring atomic interactions, and quantum nonlinear optics, which cannot be duplicated in macroscopic systems even in principle. Targeted breakthroughs include:1) Nanoscale traps using quantum vacuum forces. Nanophotonic structures enable strong quantum vacuum forces acting on atoms near dielectric surfaces to be harnessed for novel “vacuum traps.” Their figures of merit (e.g., trap depth and spatial confinement) will exceed what is possible with conventional trapping techniques by 1-2 orders of magnitude.2) Strong long-range spin-photon-phonon interactions. We will show that nanophotonic systems enable the formation of new “quasi-particles” consisting of atoms dressed by localized photonic clouds. These clouds produce strong multi-physics coupling between photons and atomic spins and motion, facilitating novel long-range interactions and the generation of exotic quantum states of light and matter.3) New routes to single-photon nonlinear optics. We will develop novel techniques to attain strong interactions between individual photons, which are not based upon the saturation of atomic transitions. These approaches will take advantage of engineered long-range interactions between atoms, and “atom-optomechanics” in which the optical response of atoms and their motion strongly couple. S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Generation of  a new class of antiretrovirals targeting HIV-cellular cofactors interactions', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Highly active antiretroviral therapy is effective at controlling HIV-1 replication, however emergence and transmission of drug-resistant viruses is increasing, including viruses resistant to the newly developped integrase catalytic inhibitors. It is essential that new antiretrovirals (ARVs) become available. Most ARVs in development belong to the classes of viral enzyme inhibitors. Since HIV requires cellular cofactors for its replication cycle, we aim to develop novel classes of ARVs inhibiting specific virus-host interactions. Because host cell factors mutate rarely, this new class of ARVs should be less vulnerable to resistance. We selected two cellular targets, LEDGF/p75 and Transportin-SR2 (Trn-SR2), cofactors of Integrase (IN) and Capsid (CA) respectively, important for viral integration and nuclear transport. Partners of this consortium, R. Benarous, P. Cherepanov, A. Fassati and S. Emiliani, discovered, with others, these targets and elucidated their structure and function. Partner 1 SME BIODIM (FR), consortium leader, has developped small compound inhibitors of IN-LEDGF interaction. BIODIM compounds have a clear structure activity relationship, nanomolar ARV activity and are based on a new, structurally defined pharmacophore. The objectives of this project are to 1) Advance BIODIM IN-LEDGF inhibitors up to the proof of concept (POC) in man in a phase I/IIa clinical trial with partner 6 J. Gatell (SP) 2) Discover small compounds targeting the Trn-SR2 pathway in HIV-1 infection using a high throughput screening assay validated by partner 2 A. Fassati (UK), determine the pharmacophore by solving the 3D structure of Trn-SR2 with partner 3 P. Cherepanov (UK) and optimize the compounds up to the POC in a humanized mouse model of HIV infection with partner 5, B. Berkh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Hardware- and Network-Enhanced Software Systems for Cloud Computing' (HARNESS) under Seventh Framework.

assistant: **Objectives**

The dominant approach in offering cloud services is based on homogeneous commodity resources: large numbers of inexpensive machines, interconnected by off-the-shelf networking equipment, supported by stock disk drives. This is consistent with the predominant business model for data centre cloud computing, which leverages homogeneous computation, communication, and storage to provide low-cost application hosting.However, cloud service providers have reached a limit in satisfying performance and cost requirements for important classes of applications, such as geo-exploration and real-time business analytics. In particular, their platforms cannot benefit from the revolution in new hardware and network technologies for computation, communication, and storage, such as FPGAs, GPGPUs, programmable routers, and SSDs, which promise vastly increased performance, reduced energy consumption, and lower cost profiles. Their heterogeneity and complexity makes integrating them into the platform a fundamental challenge.The HARNESS project aims to bring these innovative resources into cloud platforms through a rich programme of research, validated by commercial and open source case studies. The innovations brought by HARNESS include: precise models describing requirements, policies, and expected performance of heterogeneous hardware and network resources; new virtualisation techniques tailored to these resources for flexible allocation and reallocation; advanced techniques for optimising cost/performance allocation trade offs, including spot pricing; an integrated, next-generation platform service (PaaS) for cloud-hosted applications, extending upon but compatible with existing standards; and software engineering principles for enabling applications to take full advantage of heterogeneou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Efficient sequential decision making under uncertainty'.

assistant: **Concept**

Many applications require efficient methods for automated decision making, such as control systems, crisis response, finance, logistics, network security, robotics and traffic management. These problems involve sequential learning and decision making under uncertainty in an unknown environment. As we have incomplete information about the state and dynamics of the  environment, the outcome of any specific plan is uncertain. Statistical decision theory offers a framework for finding optimal solutions, but in most problems of interest exact inference and planning are intractable.The project will develop efficient approximate methods for nearly optimal learning and decision making in such problems. Our first goal is to obtain provably efficient algorithms for decision making in discrete, fully observable environments.  Our second goal is to extend these to continuous and partially observable domains.  Recent advances in statistical learning theory and in stochastic planning, make this avenue of research particularly promising. Our third theoretical goal is to consider collaborative planning among multiple agents in unknown environments for each of the above cases.Finally, we shall develop open source code and perform extensive comparative experiments in classical benchmark problems for evaluation purposes. As a more realistic test-bed, we shall focus on the network intrusion detection and response problem, where we must safeguard a network against the attacks of malicious users.The project coordinator is an expert on Bayesian reinforcement learning and stochastic planning and the host institution has produced seminal breakthroughs in the area of distributed planning, while both have prior experience in problems of network intrusion detection.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of in vitro detection techniques for analysing allergen-specific t cell responses in humans' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The project aims at the development of a reliable in vitro T cell test system for diagnosis of contact allergy. Limitations of previous T cell-based models will be overcome through supplementation with recombinant cytokine cocktails and addition of monocot-derived antigen presenting cells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Beyond 5G multi-tenant private networks integrating Cellular, WiFi, and LiFi, Powered by ARtificial Intelligence and Intent Based PolicY'.

assistant: **Innovation**

The first generation of 5G networks launching commercially in 2019 will focus on the eMBB service for the retail sector. Thus, public 5G networks will not be able to address, in the short term, the promise of novel critical communication services required by vertical users. Private 5G and beyond 5G networks are seen as a promising way to bridge this gap, allowing private venues to deploy the required 5G capabilities early on. Factories and private venues, like stadiums or transportation hubs, are seen as key early adopters of these technologies.5G-CLARITY puts forward a beyond 5G architecture for private networks, which features a novel access network integrating 5G, WiFi, and LiFi, compute and transport resources, and novel management components to enable AI driven network automation. Based on this architecture, 5G-CLARITY will define communication services that deliver measurable enhancements with respect to the eMBB and URLLC services defined by 3GPP in Release 16, in terms of low latency, area capacity, reliability, and accurate positioning and synchronization capabilities. In addition, 5G-CLARITY will develop a management plane featuring SDN/NFV components together with an AI engine that will automate network management by receiving high level intent policies from the network administrator.5G-CLARITY brings together an ambitious consortium that ensures the delivery of the project innovations to standard bodies, where 3GPP, O-RAN, IEEE802.11bb, and ETSI-ZSM, have already been identified as preferential targets. Finally, the 5G-CLARITY technology will be demonstrated in two relevant use cases, including a human-robot interaction application in a museum in Bristol, and a network slicing and AGV positioning application for Industry 4.0 services in a factory near Barcel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'TAnk HYdrogen Automotive'.

assistant: **Concept**

While automakers have demonstrated progress with prototypes and commercial vehicles traveling greater than 500 km on a single fill, this driving range must be achievable across different vehicle makes and models and without compromising customer expectations of space, performance, safety, or cost. The TAHYA project, mainly led by industrial partners -already involved in producing and manufacturing hydrogen solutions for the automotive and aviation industry-, will focus on the development of a complete, competitive and innovative European H2 storage system (a cylinder with a mounted On-Tank-Valve with all integrated functionalities) for automotive applications up-performing the actual Asian and US ones. The TAHYA consortium composed of Optimum CPV, Anleg, Raigi, Volkswagen, Chemnitz University of Technology, Bundesanstalt für Materialforschung und -prüfung, PolarixParner and Absiskey will ensure that the development phase of the storage system remain in line with the expectations (cost, performance and safety) required by the market, end users’ and car manufacturers.The key objectives of the TAHYA project are: OBJ#1: Preparatory work to provide a compatible H2 storage system with high performances, safe and Health Safety Environment responsible.OBJ#2: Provide a compatible H2 storage system with mass production and cost competitive.OBJ#3: Regulation Codes and Standards (RCS) activities to propose updates on GRT13 and EC79 according to tests results obtained over the duration of the project.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'HEritage Resilience Against CLimate Events on Site' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

HERACLES main objective is to design, validate and promote responsive systems/solutions for effective resilience of CH against climate change effects, considering as a mandatory premise an holistic, multidisciplinary approach through the involvement of different expertise (end-users, industry/SMEs, scientists, conservators/restorators and social experts, decision, and policy makers). This will be operationally pursued with the development of a system exploiting an ICT platform able to collect and integrate multisource information in order to effectively provide complete and updated situational awareness and support decision for innovative measurements improving CH resilience, including new solutions for maintenance and conservation. The HERACLES effectiveness will be ensured by the design and validation of manageable methodologies also for the definition of operational procedures and guidelines for risk mitigation and management. It will be validated in two challenging test beds, key study cases for the climate change impact on European CH assets. The strength of HERACLES solutions is their flexibility in evaluating a big quantity of different information that can be changed and tailored to the specific CH assets needs, guaranteeing in that way a general applicability. In  this context, a fundamental role will be played by end-users, which will be active part in the project activities. HERACLES system will be designed and developed by accounting for the economic sustainability and future acceptance by the market and for the social and economic impact for public and local communities while respecting the integrity of CH and the value it hold for communities. Effective technological transfer of HERACLES outcomes to large companies, SMEs and end users, suitable disseminati