RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Direct and Indirect Emotion Regulation as a New Path of Conflict Resolution'.

assistant: **Innovation**

Intractable conflicts are one of the gravest challenges to both humanity and science. These conflicts are initiated and perpetuated by people; therefore changing people's hearts and minds constitutes a huge step towards resolution. Research on emotions in conflicts has led to the realization that intergroup emotions are critical to conflict dynamics. This project’s intrinsic question is whether and how intergroup emotions can be regulated to alter attitudes and behavior towards peace. I offer an innovative path, using two strategies of emotion regulation. The first is Direct Emotion Regulation, where traditional, effective emotion regulation strategies can be used to change intergroup emotional experiences and subsequently political positions in conflict situations. The second, Indirect Emotion Regulation, serves to implicitly alter concrete cognitive appraisals, thus changing attitudes by changing discrete emotions. This is the first attempt ever to integrate psychological aggregated knowledge on emotion regulation with conflict resolution. I propose 16 studies, conducted in the context of the intractable Israeli-Palestinian conflict. Seven studies will focus on direct emotion regulation, reducing intergroup anger and hatred, while 9 studies will focus on indirect regulation, aspiring to reduce fear and despair. In both paths, correlational and in-lab experimental studies will be used to refine adequate strategies of down regulating destructive emotions, the results of which will be used to develop innovative, theory-driven education and media interventions that will be tested utilizing wide scale experience sampling methodology. This project aspires to bridge the gap between basic and applied science, creating a pioneering, interdisciplinary framework which contribute
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Stretchable mesh-electrodes interfacing human iPSC brain organoids' (STRELECOID).

assistant: **Innovation**

Recent advances in cellular engineering allow to recruit skin cells from donors and reprogram them into neural stem cells. These induced pluripotent stem cells (iPSC) bear the genetic code of the human patient. Efforts to culture these cells in-vitro have been successful in creating a wide variety of 3D arrangements called neurospheres. Because the human central nervous system is by and large inaccessible at all developmental stages, these functional tissue preparations are invaluable. Furthermore, clinical studies performed in animal models are known to translate poorly to humans and therefore these systems provide unprecedented advantages: human neurons in a controlled environment that have the genetic signature of psychiatric or mental disorders borne by the donor patient, such as Alzheimer’s or Parkinson’s disease. Finally, compared to animal studies where overwhelmingly only male animals are studied, stem cell research can operate on both sexes.The combination of new biomaterials, genome engineering and massively parallel single-cell transcriptomics opens opportunities to precisely study human brain diseaseA new exciting development is the possibility to form so-called assembloids, whereby organoids of different brain regions, as for example cortical and thalamic neural ensembles, are brought in proximity and self-assemble into anatomically correct brain regions. These approaches are necessary to study disorders like epilepsy. However these cultures lack physiological sensory input which are key in the development of mental plasticity. Here we plan to overcome this limitation by integrating new mesh-based electrodes that integrate seamlessly into brain tissue and expand symbiotically with the neurosphere as it grows, and thereby have a spatially refined mean to mea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Comparative Study of Voice Perception in Primates' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

With COVOPRIM I propose to reconstruct the recent evolutionary history of one often overlooked component of speech and language: voice perception. Perceptual and neural mechanisms of voice perception will be compared between humans, macaques and marmosets –two highly vocal and extensively studied monkey species–to quantify cross-species differences and infer mechanisms potentially inherited from a common ancestor. Two key building blocks of vocal communication detailed in my past research in humans will be compared across species: (1) the sensitivity to conspecific vocalizations, and (2) the processing of speaker/caller identity.COVOPRIM is organized in three workpackages (WPs). WP1 will use large-scale behavioural testing based on ad-lib access of monkeys to automated test systems (following the highly successful model developed locally with baboons). Two main behavioural experiments will establish psychometric response functions for robust cross-species comparison. WP2 will use functional magnetic resonance imaging (fMRI) to measure cerebral activity during auditory stimulation in the three species. I will compare across brains the organization of what I hypothesize constitutes a “voice patch system” similar to the face patch system of visual cortex and broadly conserved in primates. I will also take advantage of the monkey models and use long-term, subject-specific enrichments of the auditory stimulation to probe the experience-dependence of neural coding in the voice patch system—an outstanding issue in human voice perception. WP3 will use fMRI-guided microstimulation in monkeys and transcranial magnetic stimulation in humans to establish the effective connectivity within the voice patch system and test the causal relation between voice patch neuronal activity and v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'IntraVenous Immune Boost'.

assistant: **Concept**

What if we could finally treat metastatic patients and uncurable cancers like sarcomas ?HEPHAISTOS-Pharma developed ONCO-Boost, the first-in-class intravenous TLR4 immunostimulant that will be a game changer in immunotherapy. This innovation was discovered after 40 years of research from a woman entrepreneur who developed a mature, scalable, disruptive and eco-friendly platform. ONCO-Boost can cure hard to treat cancers as a stand-alone treatment but can also increase the efficacy of existing treatments. Our cure is injected intravenously and this changes everything, we can offer therapeutic options for patients with metastatic cancers and hardly accessible tumors. As such, ONCO-Boost can cure 10x more patients than competitors, all limited to intratumoral injection. HEPHAISTOS' ambition is to become the European leader in immunostimulants, with a platform able to supply the market with large quantities of drugs, able to save millions of patients each year.


**Keywords:** TLR4, immunostimulant, immuno-oncology, immunotherapy, osteosarcoma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Characterization of the role of nuclear factor rip140 in estrogen receptor mediated transcription' to be submitted under Fourth Framework.

assistant: **Abstract**

TRANSCRIPTION ACTIVATION BY THE ESTROGEN RECEPTOR AND OTHER NUCLEAR RECEPTORS REQUIRES TRANSCRIPTION INTERMEDIARY FACTORS (TIFS). RECENTLY, A NOVEL NUCLEAR FACTOR (RIP140) HAS BEEN CLONED WHICH BINDS TO THE ESTROGEN RECEPTOR IN THE PRESENCE OF LIGAND. THIS INTERACTION REQUIRES A SHORT SEQUENCE IN THE LIGAND BINDING DOMAIN OF THE ESTROGEN RECEPTOR WHICH IS KNOWN TO BE IMPORTANT FOR ITS TRANSCRIPTIONAL ACTIVITY, AND WHICH IS CONSERVED IN ALL TRANSCRIPTIONALLY ACTIVE NUCLEAR RECEPTORS. THE OBJECTIVE OF THIS PROJECT IS TO ATTEMPT TO ELUCIDATE THE ROLE OF RIP140 IN TRANSCRIPTION, USING TWO APPROACHES. THE EFFECT OF RIP140 ON ESTROGEN RECEPTOR-MEDIATED TRANSCRIPTION WILL BE EXAMINED IN A RECONSTITUTED SYSTEM IN BUDDING YEAST, WHICH IS DEVOID OF ENDOGENOUS NUCLEAR RECEPTORS. THE YEAST TWO HYBRID SYSTEM WILL BE USED TO IDENTIFY ADDITIONAL PROTEINS ASSOCIATED WITH RIP140, AS BIOCHEMICAL EVIDENCE SUGGESTS THAT IT EXISTS AS PART OF A HIGH MOLECULAR WEIGHT COMPLEX WHICH MAY BE IMPORTANT FOR ACTIVATED TRANSCRIPTION.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Geometric algorithms for industrial application' under Fourth Framework.

assistant: **Concept**

The area of computational geometry has developed over the last twenty years as a discipline of theoretical computer science, which drew much of its motivation from geometric applications (computer graphics, robotics, VLSI design, CAD, GIS, scientific computing). It has extracted the essential basic geometric algorithmic problems and developed efficient solutions for them. Only a few of the results had previously made their way into the application areas.The goal of the project was to make the most important of these solutions and methods available to users in industry and academia in the form of a C++ library: CGAL (Computational Geometry Algorithms Library). The distinguishing features of CGAL are the careful and efficient treatment of robustness issues, the wide scope of the algorithms and data structures provided, and flexibility, extendibility, and ease of use.Expected deliverables:The deliverables of the project were to take the form of software packages to be incorporated into the library, research reports on the algorithmic and software engineering issues related to these software packages, and web pages, tutorials, and presentations about CGAL targeted for the user community. The software to be provided included a core infrastructure for constructing correct, flexible, and efficient geometric software. This was to take the form of work packages dealing with robustness issues, program checking, maintenance and evaluation, and interactive visualization. Software modules for spatial subdivisions, arrangements, Nef polyhedra, triangulations, Delaunay and Voronoi diagrams, data structures for geometric queries including secondary memory, and geometric optimisation were also to be delivered. In addition, a commercial version of the library was to be made available thr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Qualitative Jump in Customer Experience: Omnichannel Impact of Distributional Semantics' (SentiSquareCX) under Horizon 2020.

assistant: **Objectives**

Understanding customer voice is fundamental in building products, services and customer facing processes. Although companies have abundance of data, they still lack insight. According to Gartner, fewer than 10% of companies have a 360° customer view, and only 5% are able to use it to systemically grow their businesses. The reason is that listening to customers has been difficult and technologies available either arduous to use, non-scalable or providing skewed interpretation of the data collected. To meet the needs of data intensive industries and deliver cost-effective NLP, we offer our AI-based, self-learning solution for any text. It is language agnostic, applicable thus to any language without limitations and even in multi-language datasets. Compared to alternatives, where search content is predefined (pre-tagged), our disruptive technology genuinely reflects the actual meaning of text, not being limited by lexicons or biased by content predefinition. The unique qualitative advantage of our engine stems from our research in Distributional Semantics. This approach enables the vectorial representation of word meaning. Every word is associated with a vector which reflects the contextual (distributional) information across a text dataset. Vectorial representation allows us to quantify the similarity between meanings. On this basis, our algorithms are employed to automatically discover hidden patterns. We realize that most data in organizations is about customer engagement. For this reason, we want to offer the portfolio of products covering the entire multichannel 360° view: providing AI-powered analytics from insights, through inbound communication assistance, to contact center process automation to semantic segmentation. Private and public organizations, with large vo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Contactless, Multidimensional Sleep Monitoring and Assessment Solution', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Sleep loss is an aggravating factor in the global burden of disease with collateral effects on cardiovascular and mental health as well as injury and death through human error. State of the art clinical diagnostic tools that measure sleep data are expensive, complex to interpret, and stressful for the patients. Today’s most accurate diagnostic tools require patients to strap electrodes and chest monitors to their body and undergo overnight testing, often in a clinic. Sleepiz AG has developed a breakthrough solution in clinical sleep-monitoring solutions. Our innovation, Sleepiz, is a contact-free sensor-based diagnostic device for sleep specialists and clinics. It can analyze patients’ vital signs and environmental measurements without touching the patient. We use test results to continuously feed and improve our self-learning algorithms. Sleep specialists will prescribe Sleepiz to patients to use in their homes. Doctors can view the results remotely and in real-time. We will charge clinics a fee per session in line with today’s diagnostic costs; our solution will be up to 2x more time- and cost-efficient. The approval of Sleepiz as a clinical diagnostic device in the EU and US, together with the ramp-up of commercial activities and stakeholder outreach, comprise the major objectives of this project.The goal of phase 1 is to further validate product-market fits, along with planning and allocating resources for clinical validation trials during phase 2. Sleepiz AG is a Swiss startup comprised of young entrepreneurs and innovators. We have already created great interest: 4 hospitals that use clinical-grade sleep diagnosis tools - a market worth close to €5Bn – want to validate our system. An advisory board of leading experts in related tech and innovation fields will help
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sleep microstructure in Parkinson's Disease and REM-sleep Behavior Disorder' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Idiopathic REM sleep Behavior Disorder (iRBD), a condition characterized by abnormal behaviors during sleep associated with dream enactment, is considered a prodromal state of Parkinson’s disease (PD). Both disorders share a common pathophysiology consisting of abnormal protein deposition from the gastrointestinal tract to the brain via ascending pathways. Whereas motor aspects have been extensively studied in iRBD/PD, a comprehensive view of the effects of the pathology on sleep-wake microarchitecture is still lacking. This Sleep_PD-RBD project focuses on the sleep disturbances associated with iRBD/PD and what they may reveal about the neurodegenerative process. Besides characterizing alterations in vigilance state regulation and sleep oscillations, I will correlate these EEG observations to gastrointestinal symptoms and daytime sleepiness, which both greatly impair patients’ quality of life. The original aspect of this project consist of studying sleep alterations with the recent concept of sleep and wake as non-mutually exclusive states, emphasizing sleep-wake dynamics as opposed to sleep scoring with conventional polysomnography variables, and with innovative EEG analyses investigating the properties of specific sleep oscillations and their cross-coupling. The project also links the brain to the guts, a current hot research topic. This multi-disciplinary project will rely on retrospective databases of patients obtained in Lyon and collaborative centers across France, as well as ongoing recruitment of patients and controls. For this project, I will benefit from the strong expertise of the Lyon Neuroscience Research Center in neuroscience research and of the Center for Sleep Medicine and Respiratory Diseases of Lyon University Hospital for clinical research aspects. W
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Stimulated Brillouin Scattering based RF to Optical Signal Transduction and Amplification'.

assistant: **Innovation**

While the detection of weak signals (down to the single photon level) in the optical frequency range is routine on account of the high photon energy (compared to thermal excitation energy kBT) and the availability of efficient detectors, this is not the case in the radio frequency (RF) and microwave frequency regimes wherein thermal (Johnson) noise in detectors swamps out the faint RF signals (in applications from radio astronomy, MRI to radar) and requires the use of cryogenic amplifiers. The ability to map signals efficiently from the microwave to optical regime becomes paramount for distant systems to communicate with each other using low loss telecom fibers. Both classical (radio over fiber systems) and quantum (linking two superconducting qubit processors in two dilution fridges) information processing systems will benefit greatly from the development of an efficient RF to optical signal transducer. I have been developing efficient RF to optical transduction schemes in GaAs cavity optomechanical systems (KC Balram et al., Nature Photonics (2016)) by exploiting its favorable piezoelectric (for coupling RF signals to propagating acoustic waves) and elasto-optic (for engineering strong acousto-optic interactions) properties. In this project, I would like to extend this work and address the issue of weak RF signal detection by up-converting RF signals to the optical domain using integrated Stimulated Brillouin Scattering (SBS) and shot-noise limited optical detection. Piezoelectric SBS systems can also be used to build high frequency, high gain RF amplifiers with noise figures that can be lower than conventional RF amplifiers. Working in a novel GaAs on insulator platform helps provide some unique advantages (tightly confined acoustic and optical modes with large modal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Green Transformation of Steel Scrap into Next-Generation Ultra-High-Strength Steel through Advanced Process Design'.

assistant: **Objectives**

Steel remains the backbone of modern industry, but its manufacturing is one of the world's most carbon-hungry process, accounting for over 7% of worldwide emissions. With more effort directed towards achieving net-zero targets and with higher demand for ultra high-strength steels (UHSS) in transport, construction, and defence, there needs to be a radical shift in paradigm away from traditional extractive metallurgy and towards low-carbon, circular alloy design.REVALORISE-STEEL addresses this by designing a revolutionary next generation of ultra-high strength steel (UTS > 1000 MPa, elongation > 20%), fabricated from over 90% recycled ferrous scrap material. The project targets the development of advanced plain carbon steel through modified multi-phase microstructures (ferrite, martensite, bainite, retained austenite) by the application of novel thermo-mechanical processing (TMP) techniques including hot rolling, intercritical annealing, and quenching & partitioning.Among the innovations is using machine learning-based scoping of alloys with TMP verification via experimentally validated methods, accelerating alloy discovery and tailoring required microstructure and mechanical properties. The approach is based on deep understanding of phase transformation, microstructure evolution, corrosion resistance, and weldability. My research will target guiding model development, optimizing alloy processing, and performance validation against industrial standards.Life Cycle Assessment (LCA) and techno-economic studies will evaluate the economic and environmental viability of these alloys, aiming to reduce the carbon content by over 60% compared to conventional Advanced High-Strength Steels (AHSS).Supported by Imperial College London and industry collaborators and aligned with the UN