RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Photonic Integrated Components Applied to Secure chaoS encoded Optical communications systems' (PICASSO).

assistant: **Concept**

The ultimate goal of PICASSO is the development of photonic components and subsystems to build chaos-based optical communication systems. Within the framework of the project, monolithic and hybrid photonic integrated circuits will be designed and developed for the realization of chaotic transmitters and receivers. Extensive security testing, verification and calibration of the chaos encoded communication system will be performed. Different types of transmitter/receiver pairs will be fabricated and the validity of the security assumptions will be proved experimentally. Fully functional transmitter and receiver modules will be developed at four adjacent wavelengths of the ITU grid (100 GHz spacing)  in the C band of the telecommunications window operating at 2.4 and 10 Gb/s. Compatibility with the existing infrastructure will be exhaustively tested and possible interactions between chaos encoded channels and conventional neighboring channels will be investigated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Manufuture 2017 Conference' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

This project proposes to organise and hold the MANUFUTURE 2017 conference in Estonia during the Estonian Presidency. The conference will focus on the competencies and capabilities that EU companies should develop to move into higher value activities and to become globally competitive. Three major issues will be addressed in the sub-themes of the conference: energy and resource efficient manufacturing, digital manufacturing and collaborative technology innovation.  The conference will also look at a number of cross-cutting issues: the development of skills, access to finance, the use of innovative business models and better regulation. This project will support the objectives of the Estonian Presidency as well as promoting the success of the European manufacturing sector.


**Keywords:** Digital, Energy and Resource Efficient, New Business Models, Better Regulation, Innovation, Value Chain, Manufacturing Conference, Access to Finance, Collaborative Technology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'EIT Culture & Creativity Business Plan 2024-2025' (2021-2027) under Horizon Europe.

assistant: **Objectives**

The European Institute of Innovation and Technology (EIT) has launched the 9th Knowledge and Innovation Community (KIC) dedicated to the Cultural and Creative Sectors and Industries (CCSI). Founded in 2023 in Cologne, with 25 partners from 19 nations, EIT Culture & Creativity (EIT CC) aims to address the global challenges faced by the CCSI, which employs 6.2% of the European Union (EU) workforce but struggles with skills gaps, slow innovation, and limited scalability and growth.EIT CC will be co-funded by the EIT potentially for up to 15 years, with an initial grant of €25M to support Education, Innovation, and Business Creation. Its 2024–2025 Business Plan (BP24–25) marks the beginning of a journey towards financial independence. This is underpinned by a growing community of members, some 350 by 2025, who will invest to innovate in their own sectors.The partnership aims to create a sustainable ecosystem that promotes competitiveness, resilience, and long-term economic growth. Through collaboration, it seeks to strengthen industry practices, support innovation, and encourage environmentally responsible approaches, all the while enhancing the overall economic landscape for the future in a partnership with purpose. By 2025, EIT CC will train 1,500 students, support more than 90 companies (Start-ups, Scale-ups and SMEs), incubate more than 10 Start-ups through our incubation and acceleration programmes. It will also implement some 25 innovation projects across various cultural and creative fields: Architecture, Audio-visual Media, Fashion, Cultural Heritage, and Games. EIT CC will also spearhead efforts to enhance the resilience of the CCSI by developing modular Resilience Plans for organisations across Europe. By 2025, 60 pioneering stakeholders will be involved in the cr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Amelioration durable de la production de sorgho en Afrique de l'oue st par la lutte integree contre ses insectes ravageurs' under Fourth Framework.

assistant: **Concept**

The main objectives are as follows :* To recommend sorghum breeders in West Africa (WA) the best breeding strategies, including Marker Assisted Selection (MAS) & resistance sources to use for creating sorghum varieties combining high grain yield & resistance to head bugs (HB), stem borer (SB: Busseola) &/or midge (SM).* To characterize insecticidal effect of Physic nut (Jatropha) and Neem extracts, and to improve extraction and formulation techniques of these compounds, in view of protecting sorghum from damage by stem & panicle pests.* To determine the efficiency & acceptability to WA farmers of integrated pest management (IPM) packages, for reducing losses to insects on sorghum.Expected OutcomeThe work carried out in this project should accelerate the creation process of sorghum varieties combining high yield potential & pest resistance, using MAS and sources with high & stable resistance (whose genes would have been mapped). It should also result in the decentralized production of plant-derived pesticides (whose characteristics would have been documented), for use by small-scale WA farmers. Ultimately, it should lead to the adoption and implementation of IPM programs, based on technical packages with resistant varieties, plant-derived pesticides, optimum dates of sowing, and when applicable, pheromone trapping, as major components, resulting in the reduction of insect losses in sorghum yield.The key activities envisaged are :* Mapping genes of resistance to HB & SB in sorghum, using molecular markers, with field characterization (under artificial insect infestation) of resistances in progenies derived from Resistant X Susceptible crosses.* Screening & breeding sorghums for resistance to HB, SB & SM. This will be carried out on-station under both natural & artificial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Neurotropic flavivirus dsRNA-protein interface in humans, mosquitoes and ticks'.

assistant: **Concept**

Neurotropic flaviviruses Zika virus (ZIKV) and tick-borne encephalitis (TBEV) represent major emerging arthropod-borne viruses transmitted by two different vectors, either mosquitoes or ticks. In humans, they use cells of the immune system to spread throughout the organism and can lead to severe encephalitis. During their replication, viruses produce double-stranded RNA (dsRNA) structures which is not only a necessary by-product but also performs key regulatory functions and acts as a pathogen-associated molecular pattern recognized by the host innate immune response. However, viral adaptation to such divergent host cells and organisms and their immune response, especially in arthropods, is poorly understood. In this project, I propose to investigate and compare how neurotropic flaviviruses interact through their RNA in humans and arthropods. First, I will identify host factors involved in protein-dsRNA complexes using anti-dsRNA antibodies in a high-throughput proteomic approach from infected live arthropods and human models for immune and neuronal cells and compare the protein networks between each host. Second, I will select the most significant and relevant hits for a functional screening, further define the function of the best candidates that are either pro-viral or anti-viral, confirm their importance in most relevant models and characterize the molecular functions of the best candidates. Finally, I will identify the dsRNA structures and RNA species interacting with the best candidates, and determine the evolutionary pressure imposed on the viral genomes in each host. Altogether, this project will contribute to unravel the adaptation of neurotropic flaviviruses to their hosts throughout their cycles, both from a mechanistic and evolutionary perspective, help unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SEamless Integration of image guidance to break down the barrierS and enhance the efficiency of Minimally Invasive and hybrid neurosurgical Care.', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

SEISMIC aims to create a holistic approach to revolutionize neurosurgical care through seamless integration of minimally invasive surgical approaches and imaging technologies. Despite neurological conditions being the leading cause of global disease burden, minimally invasive neurosurgical techniques lag significantly behind other surgical disciplines. Current clinical procedures rely on large skull openings and fragmented imaging tools that interrupt workflow and compromise precision. Without integrated real-time guidance and minimally invasive technologies, many conditions—hemorrhagic stroke, subdural bleeds and brain tumors—remain high-risk or inaccessible. SEISMIC addresses this urgent gap by uniting a wide and multi-disciplinary consortium, to develop and integrate the next step in minimally invasive neurosurgical procedures. SEISMIC will develop and integrate 1) continuous 4D ultrasound guidance with compact X-ray for unobtrusive, real-time guidance; 2) high-fidelity simulation platforms empowering clinician training; 3) non-invasive liquid biopsies that bypass the blood-brain barrier; and 4) minimally invasive surgical techniques to treat lesions without needing large skull openings. These breakthroughs will be validated in four high-impact clinical applications—hemorrhagic stroke, subdural bleeding, tumor diagnosis and tumor treatment—in trials assessing safety, efficacy, scalability and economic viability within a holistic assessment framework. SEISMIC will: 1) shorten procedure times and minimize surgical trauma, reducing complication rates and hospital stays; 2) accelerate recovery and improve long-term outcomes; 3) and extend specialized neurosurgical care into underserved populations. SEISMIC’s structured framework for collaborative development and rapid cl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Characterization of EWI-2wint and the mechanism behind its inhibition of HCV infection' under Seventh Framework.

assistant: **Concept**

There are more than 130 million people infected with Hepatitis C worldwide. The Hepatitis C virus (HCV) is an enveloped RNA virus targeting liver cells. HCV represents one of the most important pathogens of humans. It is still not clear how exactly viral entry proceeds. So far several receptors have been found to play a role in virus entry, among them CD81, SR-BI and Claudin-1. The recent finding of a negative regulator, EWI-2wint, further complicates the matter. This protein, which is an Nterminally processed variant of EWI-2, a direct interactor of CD81, blocks the binding of the HCV envelope proteins to the receptor CD81. Expression of EWI-2wint in cells susceptible to HCV leads to a reduced infection rate. The aim of the proposed project is to characterize the inhibiton of HCV infection by EWI-2wint. I have three specific objectives: One is to find the minimal region of EWI-2wint that is essential for its inhibitory effect. In addition, I will test whether soluble forms of EWI-2wint can act as inhibitors of infection. Another objective is the characterization of the interactions between the viral glycoproteins, CD81 and EWI-2 or EWI-2wint. The third objective is to identify the protease responsible for the cleavage of EWI-2 into EWI-2wint. The results of these experiments will help to understand the complex HCV infection mechanism and maybe also the basis for the hepatotropism of the virus, as this might be due to the absence of the specific inhibitor EWI-2wint. Expression analyses might also lead to a better understanding of the cellular role of the protease. Furthermore, an inhibiton achieved with soluble forms of EWI-2wint or the tracing of the inhibitory properties to a defined domain are an excellent starting point for the development of new therapeutic strateg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Land and sea integrated monitoring for European security' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

LIMES has the goal to define and develop prototype information services, based on satellite technology, to support security management at EU and global level in the following thematic/policy areas of interest:- Organization and distribution of humanitarian aid and reconstruction- Surveillance of the EU borders (land and sea)- Surveillance and protection of maritime transport for sensitive cargo- Protection against emerging security threats (e.g. terrorism, illegal trafficking, proliferation of Weapons of Mass Destruction).The services developed by LIMES will support the building up of a common cooperation framework between the major EU research and operational actors on Security management. LIMES has the following operational objectives: Definition, development and validation of pre-operational versions of:- Services to support Security management in EU;- Enabling Decision Support Tools and Platforms for the provision of the services.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The impact of genotoxic stress on the mRNA-interactome and RNA-regulons' under Seventh Framework.

assistant: **Concept**

RNA-binding proteins (RBP) play critical roles in stress responses like DNA-damage through interactions with elements in functionally related RNAs, termed regulons. One of the most cytotoxic forms of DNA-damage are DNA double strand breaks (DSB), that can lead to mutagenic events and when improperly repaired to cell death. This proposed project focuses on the dynamics of the global RBP network (mRNA-interactome) and RNA-regulons of mouse fibroblasts (NIH-3T3) cells in response to genotoxic stress. The “RNA-regulon” model implies that RBPs control functionally related mRNAs via cis-regulatory elements in these RNAs. Using mRNA-interactome capture and high-resolution quantitative proteomics, I will comprehensively identify mRNA-binding proteins involved in immediate DNA-repair and cell death responses to genotoxic stress. By employing deep sequencing and crosslink immunoprecipitation approaches, I will highlight the controlled RNA-networks and their influence on cell survival. Taken together, this project aims to address key questions of the role for RBPs in the DNA-damage response at different stages and the identification of their RNA-regulons. Furthermore, it opens new perspectives in posttranscriptional regulation after the cells exposure to genotoxic stress. The innovative nature of this interdisciplinary project involves European collaborators, which creates excellent inter-European-networking. The development of a novel research area will showcase the cutting-edge research performed in the ERA thus directly contribute to the European Work Programme by enhancing the attractiveness of Europe for third country and European top-scientists.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Epigenetic Profiling of Chemotherapy Efficacy', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The aim of this proposal is to showcase that chromatin regulators represent a novel class of biomarkers that can predict the response to individual drugs. The proof of concept will be established by validating our recent discovery of a 28-gene signature of chromatin regulators that predicts the response of 26 out of 31 patient-derived xenograft breast cancer models to docetaxel. Notably, in patients treated with docetaxel, though all are subjected to toxic side effects, less than half of them clinically benefit, and no test exists to predict response.  In the context of our funded ERC project, discoveries in our team underscored the key role of several chromatin regulators in establishing and maintaining chromatin landmarks, such as centromeres. In particular, our recent work demonstrated that mislocalization of the centromeric histone variant CenH3 gives cells an adaptive advantage to overcome DNA damage induced by camptothecin treatment and gamma irradiation. Further, preliminary evidence from our lab and others has highlighted a link between the expression level of chromatin regulators, including those involved in centromeres, and docetaxel sensitivity in a cellular context.  Based on these promising studies, there are three aspects that we wish to develop as proof of concept for the use of chromatin regulators as novel predictive biomarkers for docetaxel treatment. First, we wish to further illustrate our chromatin regulators as a predictive signature for docetaxel treatment. For this, we will test samples from patients having received neoadjuvant docetaxel treatment alone. Secondly, we will test the applicability of our method in other cancers and drugs through an established collaboration with Roche to predict vemurafenib efficacy in melanoma. Thirdly, we will fur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Artificial Intelligence Aided D-band Network for 5G Long Term Evolution' to be submitted under Horizon 2020.

assistant: **Abstract**

The ARIADNE project plans to bring together a novel high frequency advanced radio architecture and an Artificial Intelligence (AI) network processing and management approach into a new type of intelligent communications system Beyond 5G.  The new intelligent system approach is necessary because the scale and complexity of the new radio attributes in the new frequency ranges cannot be optimally operated using traditional network management approaches. The ARIADNE project will enable efficient high-bandwidth wireless communications by developing three complementary but critical new technologies for Beyond 5G networks in an integrated and innovative way:ARIADNE will develop new radio technologies for communications using the above 100Ghz D-Band frequency ranges, (Pillar 1)ARIDANE will exploit the opportunities emerging for advanced connectivity based on metasurfaces where objects in the environment can become tuneable reflectors for shaping the propagation environment in D-band. (Pillar 2)ARIDANE will employ Machine Learning and Artificial Intelligence techniques to management necessary for the high-frequency communications and dynamic assignment and reconfiguration of the metasurfaces to provide continuous reliable High Bandwidth connections in the Beyond 5G scenario. (Pillar 3)


**Keywords:** Artificial Intelligence, Machine learning, D-Band communications