RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Role of non-phagocytic, lymphocyte-like haemocytes in the antiviral and antibacterial defence of shrimp' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Shrimp (Penaeus vannamei) aquaculture industry is the fastest-growing sector of the global aquaculture is threatened worldwide by viral diseases, of which White Spot Syndrome is the most harmful and bacterial diseases, of which Vibriosis is the most damaging. Therefore, appropriate biosecurity and management measures in shrimp aquaculture are important in preventing diseases. Stimulating the immunity in shrimp is another factor that can help shrimp in surviving infectious attacks. Although the immune system of invertebrates has been well studied in insects, much less information is currently available for crustaceans. The general concept in a crustacean is that there are three types of haemocytes in the circulating haemolymph, but recent research in the laboratory of Prof. Dr Hans Nauwynck indicated that the haemocytes of P. vannamei can be separated in five distinguished subpopulations, of which two subpopulations were previously not described. The cells of these two subpopulations resemble mammal lymphocytes and are therefore designated lymphocyte-like haemocytes (LLHs). Against this background, it is paramount to investigate the immunological function of these LLHs in depth. ShrimpLLH project objectives are (i) to isolate, (ii) to characterize and (iii) to analyze the immunological functions of haemocyte subpopulations. This project will further fill the knowledge gap in shrimp immunity, more specifically, it will provide information on the immunological role of LLHs. Since this project is multidisciplinary, it will increase the competence of the candidate in advanced immunological techniques and experience in crustacean innate immunity research. The new knowledge gained in this project will facilitate to develop a technique to screen products that can aid the shrimp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Foundations of Factorized Data Management Systems' (FADAMS).

assistant: **Concept**

The objective of this project is to investigate scalability questions arising with a new wave of smart relational data management systems that integrate analytics and query processing. These questions will be addressed by a fundamental shift from centralized processing on tabular data representation, as supported by traditional systems and analytics software packages, to distributed and approximate processing on factorized data representation.Factorized representations exploit algebraic properties of relational algebra and the structure of queries and analytics to achieve radically better data compression than generic compression schemes, while at the same time allowing processing in the compressed domain. They can effectively boost the performance of relational processing by avoiding redundant computation in the one-server setting, yet they can also be naturally exploited for approximate and distributed processing. Large relations can be approximated by their subsets and supersets, i.e., lower and upper bounds, that factorize much better than the relations themselves. Factorizing relations, which represent intermediate results shuffled between servers in distributed processing, can effectively reduce the communication cost and improve the latency of the system.The key deliverables will be novel algorithms that combine distribution, approximation, and factorization for computing mixed loads of queries and predictive and descriptive analytics on large-scale data. This research will result in fundamental theoretical contributions, such as complexity results for large-scale processing and tractable algorithms, and also in a scalable factorized data management system that will exploit these theoretical insights. We will collaborate with industrial partners, who are committe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Structural Dynamics of Protein Complexes by Solid-State NMR'.

assistant: **Objectives**

Multidrug resistant bacteria that render worthless the current arsenal of antibiotics are a growing global problem. This grave challenge could be tackled by polyketide synthases (PKSs), which are gigantic modular enzymatic assembly lines for natural products. PKSs could be developed for industry to produce chemically difficult to synthesize drugs, but cannot be harnessed until we understand how they work on the molecular level. However, such understanding is missing because we cannot easily investigate large complexes with current structural biology and modeling methods. A key puzzle is how the function of these multicomponent systems emerges from atomic-scale interactions of their parts. Solving this puzzle requires a holistic approach involving measuring and modeling the relevant interacting parts together. Our goal is to develop a multidisciplinary approach rooted in solid and solution state NMR that will make possible studies of complexes from PKSs. The two main challenges for the NMR of PKSs are increasing sensitivity and resolution. Recent innovations from our lab allow application of solid-state to study large complexes in 2–10 nanomole quantities. Building on this approach, with a protein-antibody complex as a test case, we will develop new NMR methods that will enable a study of structure and motions of domains in complexes. We will probe, for the first time, the structural dynamics of PKSs of enacyloxin and gladiolin, which are antibiotics against life-threatening multidrug resistant hospital-acquired Acinetobacter baumannii infections and tuberculosis. These studies will guide rational engineering of the PKSs to enable synthetic biology approaches to produce new antibiotics. If successful, this project will go beyond the state of the art by: enabling studies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Immunogenic cell death in anticancer therapy'.

assistant: **Objectives**

We advocate the hypothesis that successful chemotherapeutics can induce a type of tumor cell stress and death that is immunogenic, meaning that the patient’s dying cancer cells serve as a vaccine that stimulates a specific antitumor immune response, which in turn can control (and sometimes even eradicate) residual cancer cells. This is a highly original – and necessarily controversial – “breakthrough” concept since it challenges previous belief that anticancer chemotherapies act solely on the tumor cells, without any significant involvement of the host immune system. Cell death is usually non-immunogenic, and only a small minority of chemotherapeutic agents can induce immunogenic cell death, which - in contrast to classical apoptosis - is preceded by two types of pre-mortem stress, autophagy (which is required for cellular ATP release, an obligatory signal of immunogenicity) and endoplasmic reticulum (ER) stress (which is required for calreticulin [CRT] exposure at the cell surface, another obligatory signal of immunogenicity). Here, we will explore the hypothesis that cancer cell death is only immunogenic if the two pathways of pre-mortem stress, autophagy and ER stress, are simultaneously activated. Thus, we aim at “decoding” the anticancer drug-induced cellular pathways that regulate the immunogenicity of cell death. For this, we will trigger cancer cell death preceded by one or the two types of pre-mortem stress in a “synthetic system” (by genetic manipulation involving inducible transgenes in cancer cells and mice) or by means of selected pharmacological compounds in multiple in vitro and in vivo cancer models, as we monitor the immune-dependent therapeutic response. Moreover, we will investigate the functional links between autophagy, ER stress and immunogenic sig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Rapid doctor office test for allergy-screening' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The number of allergic persons and accompanying costs of treatment increase every year. So there is a real need for an innovative, cost effective diagnostic system for allergens. The proposed project aims to develop a new, well-defined and standardized test for allergy screening which is able to provide rapid results with sufficient accuracy in a general practitioner's environment, i.e. without the need for clinical laboratory equipment or expertise. The objectives of this project are: to develop a multipurpose test kit, with the aid of which a general practitioner could perform a simple procedure- i.e. without the need of a clinical laboratory- to support his allergy diagnosis; To supply back up service through quality assurance and confirmation testing in an expert laboratory environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Zebra Academy Ready to Market Feasibility Study' (LAB2MARKET), addressing dissemination and exploitation.

assistant: **Impact**

Stroke is the second cause of death world-wide and the second cause of disability-adjusted life in high-income countries.The burden of stroke can be mitigated by emergent expert support. Much progress has been achieved for inhospital strokemanagement, but a scalable solution to optimize prehospital care has not yet been established. Telemedicine is the primecandidate to bridge this gap by transporting medical experts virtually to prehospital for immediate initiation of care duringambulance transportation. Led by disruptive innovation, we were the first to develop a proof-of-concept for 24/7 inambulancetelestroke support using our dedicated telemedicine system. Over the past years, we have developed anintegrated audio-video and point-of-care medical device for acute stroke care which works across hospitals and emergencyvehicles. To achieve the proposed innovation we have gone through the following approaches to develop our first prototypearchitecture which has been tested in a clinical environment, involving experienced researchers in stroke and emergencycare:*Creation of the ICT platform: based on existing cloud telecommunication systems, we built the architecture with a focus onopen access of devices that has gone through several input cycles from many stakeholders. Zebra Academy has based thedevelopment of its infrastructure on EU developed technology FIWARE. Zebra Academy is also one of the certifiedsuccessful stories (FIWARE VIP) in the use of this technology.*Creation of the in-ambulance communication device: currently on its 6th phase we have gone through several lean cycles inwhich physicians, patients and ambulance personnel have given input.*Legal and ethical compliance: our legal experts have provided an overview and in-depth-analysis of applicable legal issue
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cultural HERItage and the planning of European LANDscapes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

European countries have a long and successful history of conserving their rich heritage and landscape assets in town and country, and of capitalising on them culturally and economically. Throughout the 20th century, great progress was made in creating structures and promulgating principles to guide heritage and landscape conservation, but as the 21st century proceeds, society is challenged by new far-reaching changes. These include various forms of migration, greater digital connection, environmental degradation and climate change, shifts in the public/private balance in society at large, and a renewed pressure for growth. Confronted with such a fast-changing context, heritage management needs new ideas, tools and training to ensure that interdisciplinary, research-based heritage, landscape management and spatial planning are positively integrated with business activity, development and democratic decision making. Through HERILAND, a consortium of 7 key academic and non-academic organizations, with 21 partners in civil society and business,  aims to empower a new generation of academics, policy makers, practitioners, professionals and entrepreneurs. Our research design positions heritage in the frame of five transformation processes which we identify as key challenges to the heritage management of the 21st century: The Spatial Turn, Democratisation, Digital Transformations, Shifting Demographies and Contested Identities, and Changing Environments. Using this framework, 15 PhD researchers will be provided with advanced training combining theoretical and instrumental knowledge in a series of research seminars, living labs and secondments with our public and private partners. By doing this, HERILAND will establish a new pan-European, trans-national, interdisciplinary and c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Clinical validation of Trop-2 as a serum biomarker for monitoring of disease-course in patients affected by breast and colon cancer' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

A critical need in cancer care is the possibility to monitor tumour progression, through non-invasive techniques, to recognize relapses and/or metastases at a very early stage. The measurement of tumour biomarkers circulating into the bloodstream is a feasible way, as it can give indications also on patients’ response to therapeutic treatments, thus enabling the oncologist to pursue a precision-medicine strategy. In patients affected by breast and colon cancer, most serum biomarkers employed in the clinical practice have poor specificity and sensitivity to be used as monitoring tool of the cancer progression. Oncoxx Biotech has collected strong experimental data demonstrating that the transmembrane receptor Trop-2 drives progression of several tumour types. It has also been shown that Trop-2 is a determinant of breast cancer survival, and it is released in the bloodstream in patients with breast and colorectal cancer. In this respect, the results achieved in a preliminary clinical study have shown that all higher-than-baseline levels of circulating Trop-2 identify breast cancers with 100% specificity and 80% sensitivity and colon cancer with 100% of specificity and 74% of sensitivity. Therefore, scope of the ThruBlood project is to validate Trop-2 as a serum biomarker for monitoring disease-course in patients with breast and colon cancer. During Phase 1 we will: 1) assess the scientific feasibility of the proposed biomarker by extending the population of serum samples to analyse; 2) design the Clinical Validation Study to pursue in Phase2; 3) validate a standardized procedure for accurate measurement of the serum Trop-2 levels using a proprietary device (ICONA, patented by the applicant) with aim of providing high-throughput procedures for serum biomarker detection; 4)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Creation of user-friendly mobile services personalised for tourism' (CRUMPET).

assistant: **Concept**

The overall aim of the CRUMPET project is to implement, validate, and trial tourism-related value-added services for nomadic users (across mobile and fixed networks). In particular the use of agent technology will be evaluated (in terms of user-acceptability, performance and best-practice) as a suitable approach for the fast creation of robust, scalable, seamlessly accessible nomadic services. The implementation will be based on FIPA-OS; a standards-compliant open source agent framework, extended to support nomadic applications, devices and networks.Objectives:· to develop a service-oriented architecture to establish and deploy flexible tourism services and applications;· to adapt tourism services to the various QoS levels offered by different bearer services, to changes in physical location, and to other contextual factors such as the characteristics of the terminal in use;· to develop a generic seamless execution environment across different types of networks and access devices for a range of value-added services within the tourism domain;· to explore an evolutionary approach to the integration of emerging technologies in this application area, such as the provision of services over mobile cellular networks such as GSM/GPRS/UMTS, wireless data networks such as Wireless LAN and Bluetooth, and including wired data standards such as IPv6;· to explore the use of contextual information such as presence, location (e.g. GPS), and user-preferences (e.g. service-specific preferences and preferences associated with different contexts), in order to intelligently adapt service delivery;· to explore the applicability of advanced software techniques, specifically Intelligent Agent technology, for service creation, deployment, distribution, personalisation, and interaction for nomad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'RNA-codified release of cytotoxic peptides from PNA prodrugs as a new therapeutic approach to cancer' (MolecularDoctors) targeting Seventh Framework.

assistant: **Abstract**

In this proposal we intend to develop a new medicinal chemistry concept base on cell-personalized delivery of tailored drugs. Relying on basic chemical tools such as proximity-induced acyl transfer reactions and catalytic turnover- we will use RNA biomarkers of cancer cells to trigger the specific expression of cytotoxic drugs. This approach, in addition to contribute to basic science in chemistry and chemical and cell biology and suggest new therapeutic strategies, might allow to overcome the most important observed complications in cancer treatment: selectivity and resistance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Geothermal Heat Pump For Cooling And Heating Along European Coastal Areas' (GEOCOOL).

assistant: **Concept**

The principal objective of the project is the development of a commercial size, economic, energy efficient and environmentally friendly, fully integrated turnkey ground source heat pump system for cooling and heating, targeted specifically at coastal applications in the South European region. A total reduction of non-renewable energy use of 50 - 60% is aimed, by combining the significant reduction obtained by the use of a renewable geothermal energy source (40-50%) with the optimisation of a water-to-water heat pump unit using propane as refrigerant (additional 10%).The main objective, 'environmentally safe and friendly', will be attained through the reduction in energy consumption and by the use of a natural fluid as refrigerant (propane) which has a negligible Global Warning Impact. The target is a design with low cost of purchase and installation, simple installation, low maintenance and high reliability, and requiring a reasonable small piece of land.