RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Fundamental physics with intense laser fields'.

assistant: **Innovation**

High-intensity lasers have the potential to offer groundbreaking insights into physics both within and beyond the Standard Model, as well as a wealth of applications in science, medicine, technology and industry. There is therefore an international drive to explore fundamental physics in intense laser fields, in the regime where both relativistic and quantum effects are significant.This regime will be tested at the Extreme Light Infrastructure (""ELI""), a series of next-generation laser facilities funded by the European Commission and now in construction across Europe.The programme of research we propose here will leverage existing EU funding of the ELI initiative by confronting fundamental and urgent issues in laser-matter interaction theory, issues which must be understood in order to correctly analyse and interpret the results of upcoming experimental campaigns. The objectives of this proposal are therefore to produce new theory insights and to provide theory support for the high intensity laser experiments which will be performed at ELI over the next five to ten years. The research goals are to:1. Build an analytical tool kit that abandons the basic and simplistic assumptions which have for many years constrained progress in this field.2. Provide improved estimates and new predictions for measurable signals of quantum radiation reaction and light-by-light scattering in upcoming high-intensity laser experiments.In achieving these goals a major contribution will be made to intense laser science in the EU.""


**Keywords:** Laser-particle interactions, strong fields, nonperturbative effects, pair production
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Conceptual diversity and the evolution of abstract thought' (CONCEVO), addressing dissemination and exploitation.

assistant: **Impact**

Human cultural evolution Human cultural evolution is often traced via ancient pot-shards, cave paintings and ritualistic traditions. But a greater challenge is to unravel the abstract concepts behind these physical traces. Cultural evolution involves not just artefacts and practices, but also the transmission of conceptual structures – ways of mentally representing the world – with continuous intergenerational transmission over thousands of years. Cultural areas in distinct parts of the world have developed some strikingly different conceptual structures, but there are not yet established methods for systematically investigating this conceptual diversity.CONCEVO aims to uncover histories of conceptual dissemination in cultural areas, from the most basic types of concepts such as HAND or DOG, to higher-order, culturally significant concepts such as SPIRIT ANCESTOR or EXCHANGE PARTNER. I will develop a new methodology that combines the featural analysis of lexical semantics with the spatial and phylogenetic analyses of evolutionary linguisitcs. This approach builds on existing lexical-conceptual databases, while also developing a completely new type of data for comparative research on culturally significant concepts. These datasets will enable our team to identify areas in which cultural transmission has occurred between multiple language groups over thousands of years, and infer the origins and dissemination pathways of the most regionally significant concepts. These higher-order concepts are crucial to humans’ ability to live in social groups, and are therefore one of our most important evolutionary developments.CONCEVO will be built around case studies of two focal regions, Australia and Papua, both of which underwent thousands of years of relatively separate cultural
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Efficient Planning Identifying Cities with Subtainability' under Fifth Framework.

assistant: **Concept**

Elaborate the first European guide on sustainable urban planning according the revision of the master plans adopted at ParcBIT (Palma de Mallorca) Kronsberg (Hannover) and Leidsche Rijn (Utrecht). The guide will analyse the aspects dealing with the sustainable and energy-efficient approach included in land planning, construction, traffic, water & waste handling, green materials, integration, energy supply and energy saving measures. The elaboration of this guide will provide to architects, town planners and urban responsible the guidelines and the practical results of sustainable master planning. These guidelines will become the fist practical handbook procuring not only urban solutions but also showing the effects in four remarkable sites.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Innovative Abradable/abrasive Materials For Improved Energy Efficiency In Gas Turbines.'.

assistant: **Innovation**

In the present project we plan to improve the energetic of gas turbines. This task will be accomplished by developing improved abradable seals to reduce the shroud/rotor gap in order to reduce back flux of gases in the high temperature combustion region of the turbine. These materials will have to be able to resist to high temperature, erosion, and oxidation, as well as to provide easy and controlled abrasion. They will also have to be cost effective and show the possibility to be manufactured by methods compatible with industrial manufacturing.Our calculations show that by means of these materials the turbine efficiency can be increased of at least 1% over present day technology that is providing an overall efficiency improvement of 0,3%-0,5/ depending on the engine size. This improvement will result in a reduction of CO2 emission in the atmosphere of at least 0,2-0,3 MTons/Year and higher as the technology is adopted worldwide.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Stalling the Replication Fork via the Impedimental Stabilization of Higher-order DNAs'.

assistant: **Objectives**

Cancer is a generic term for a group of diseases characterized by the uncontrolled growth and spread of cells with abnormal proliferating activity. Most of the anticancer drugs currently used in the clinic trigger irreversible DNA damages and thus, promote replicative stress. As an alternative of irreversible DNA strand breaks, the non-covalent small-molecule stabilization of unusual, non-B DNA structures has emerged as a promising way to create DNA damages. One of such non B-DNA structures is a three-way DNA junction that might fold both upstream and downstream of the replication fork. The stabilization of three-way junctions by small molecules therefore opens a promising way to induce replicative stress in a highly cancer-specific manner. The main goal of the project ""STARFISH DNA"" (for ""Stalling the Replication Fork via the Impedimental Stabilization of Higher-order DNAs"") is to identify a new series of compounds capable of creating DNA damages through three-way junction stabilization and to use them either as standalone therapeutic agent to fight against cancers or in combination with established drugs that disrupt cancer signaling pathways in a synergistic manner.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Transgenic dissection of the neural circuitry of memory and dementia' (MECEDGE), addressing dissemination and exploitation.

assistant: **Impact**

Our memories are arguably what make us who we are, making dementia a particularly cruel disease. Decades of research have revealed that two interconnected brain regions, the medial entorhinal cortex (MEC) and hippocampus (HP), are required for successful spatial memory formation in mammals. Each region contains specialized neurons that fire relative to the animal`s position in physical space: grid cells in the MEC have regularly-repeating spatial firing fields throughout the entire environment (“grid field”); and place cells in the CA1 region of the HP fire at a particular location within an environment (“place field”). Spatial information from the MEC grid cells reaches CA1 place cells in two ways: through an (1) indirect pathway (IP) via layer II MEC neurons, or a (2) direct pathway (DP) via the layer III MEC neurons. Thus, hippocampal neurons compare processed and unprocessed input. However, the relative roles of these two kinds of input onto hippocampal firing patterns remains elusive, largely due to the difficulty in performing layer-specific manipulations. The Kentros lab at NTNU has developed a novel and exciting genetic technology that makes such experiments possible. Therefore, I propose to conduct in vivo electrophysiological recordings in CA1 while manipulating the DP to determine the effects of direct MEC input on hippocampal network dynamics. I will then investigate the behavioral ramifications of manipulating the DP on spatial task performance. Interestingly, the superficial layers of entorhinal cortex are the first brain area to exhibit the pathological signs of Alzheimer`s Disease (AD) in patients. Therefore, I will compare the relative roles of entorhinal layer II and III neuron activity in the progression of pathology in a preclinical mouse model of AD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Exploring the Molecular Bases that Regulate Apoptosis, Cytokine production and Interaction with Neutrophil Granulocytes by 6-sulfo LacNAc+ dendritic cells (slanDC)' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Dendritic cells (DC) are composed of multiple subsets with distinct functions at the interface of the innate and adaptive immunity. Two major subsets of DC circulate in human peripheral blood: the myeloid DC (mDC) and the plasmacytoid DC (pDC), which can be distinguished by the expression of specific surface markers. Within mDC, slanDC are the most abundant in human blood and are characterized by a selective phenotype (6-sulfo LacNAc+, CD1c–, CD11c+, CD14–, CD16+, CD45RA+, C5aR+). They undergo spontaneous maturation if cultured in the absence of erythrocytes. Once matured, they are characterized by a high potential to produce pro-inflammatory cytokines such as IL-12p70 and TNFα, to prime naive T cells to become Th1 cells and to activate NK cell responses. While slanDCs may certainly play a crucial role in the control of immune response, a detailed knowledge on their involvement in autoimmunity, transplantation rejection and cancer biology is still missing. The central importance of slanDC in immune regulation makes, therefore, additional studies necessary to better understand the biologic role of this DC subset. For such a purpose, the project will focus on three main objectives:(1) to study the molecular mechanism(s) regulating IL-12p70 production by slanDC during their maturation and their cross-talk with neutrophils. To reach this objective, I will determine how IL-12p70 gene expression is controlled at a transcriptional and post-transcriptional level upon activation by TLR agonists and other stimuli.(2) to investigate the molecular mechanism(s) whereby LPS regulates slanDC survival: expression of Bcl-2 family proteins and ceramide metabolism will be analyzed.(3) to study the pattern of chemokine/chemokine receptor expression by TLR-activated slanDC.Results obtained
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'The development of classified safe coaster structures based on validated assessment tools of the damage robustness and damage stability'.

assistant: **Innovation**

The safety of ships is an important issue which falls under the responsibility of the International Maritime Organisation (IMO). In the near future, newsafety regulations to ships of the coaster category (80m<1<100m) will be issuedwhich will result in the placing of additional bulkheads in the cargo hold. Theconsequences for the shipping industry are: 1) lower operability. 2) cargo(un)loading will take more time. 3) higher harbour costs. 4) 2% higher capital investments. The only way to avoid these undesirable additional bulkheads inthe cargo hold, is to develop a coaster structure which complies the new safetyregulations: a classified coaster structure. The Consortium consisting ofshipbuilders, shipping industry, classification societies and TNO Centre forMechanical Construction, intends: 1) to develop assessment tools of the damage robustness and damage stability of coasters, and 2) to design and construct newcoaster structures with improved mechanical strength, and 3) to execute of fullscale collision and groundings experiments, in order to , 4) validate thedeveloped assessment tools, and, 5) to classify coaster structures with respectto the new set of IMO regulations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mechanical activation of beta-catenin signalling' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

During embryonic morphogenesis, cells do not only generate forces necessary for shape changes and tissue movement but also sense and respond to the forces exerted on them by neighbouring cells and tissues. Recent studies demonstrate, that these forces can act as mechanical cues during development regulating cytoskeletal remodelling, cell proliferation and gene expression. However, in most cases the molecular mechanism by which cells sense and transduce a mechanical signal into a biochemical signal remains to be discovered. Therefore, my proposed project aims at identifying the primary mechanosensitive element during Drosophila gastrulation that initiates the activation of the beta-catenin pathway in stomodeal cells in response to mechanical strain that leads to the release of beta-catenin from adherens junctions (AJ) and its translocation to the nucleus, where it activates the transcription of a key regulator gene. In order to identify the molecular mechanism that translates a mechanical strain signal into a biochemical signal I will analyse the AJ complex in vivo for molecular changes in its dynamic interaction and conformation upon mechanical deformation during gastrulation. For this, I will make use of advanced fluorescent microscopy techniques in conjunction with classical biochemical assays. In addition, I will perform in vitro two cell assays to determine the strength and type of deformation needed to induce a conformational change. Ultimately, the information gained about the mechanosensitive element will be used to design a fluorescent probe to directly monitor the mechano-activation in response to the morphogenetic movements during Drosophila gastrulation. To my knowledge, this would be the first time in vivo to visualise directly the activation of a primary me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Analyses of t cells in transgenic mice carrying humanized" mhc and cartilage as a model for rheumatoid arthritis"' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Rheumatoid arthritis is genetically associated with the major histocompatibility complex class II region (HLA-DR4) suggesting involvement of T cell mediated autoimmune recognition of joint specific antigens. Only cartilage contain joint-specific proteins. The most widely used model is arthritis induced with type II collagen (CII), The major protein component of cartilage. To understand the role of CII-reactive T-cells a series of precisely designed transgenic mice are available in Lund. This includes mice with human CII instead of mouse CII in cartilage (obtained by crossing human CII transgenic with mouse CII deleted mice) and mice with functional expression of human DR4. They have already defined the epitope in human CII recognised by murine T cells. This epitope can be recognised in its glycosylated form. Partially tolerised T-cells against this epitope develop in mice expressing the epitope in cartilage and the mice will eventually develop arthritis. I will analyse the precise nature of the tolerance. The methods I will use include T-cell cloning, cytokine analysis and TCR sequencing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A bio-active cochlear implant for severe deafness' (BIOEAR) under Fifth Framework.

assistant: **Objectives**

A cochlear implant (CI) is a neuro-prosthesis for severe deafness. Our main objective is to pharmacologically treat the auditory nerve after CI, to protect the nerve from implantation trauma and to re-grow its peripheral processes. This treatment should improve speech understanding, enhancing the life quality of the patient. Animal studies, and studies on human tissue samples, will be performed to determine the efficacy of neurotrophins and antioxidants in preserving the auditory nerve following deafness. Delivery systems will also designed to supply drugs at the time of CI. Safety, effectiveness and dosage will be investigated, leading eventually to the first human trials of NTF in the inner ear. The outcomes of the research will have implications for the pharmacological treatment of hearing loss, for the use of NTF to prevent neural degeneration in CNS and for other neuroprostheses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Teleost mucosal B1-like lymphocytes at the crossroad of tolerance and immunity'.

assistant: **Objectives**

B cells are one of the main players of immunity, responsible for the production of immunoglobulins (Igs). In 2011, I was granted an ERC Starting grant to undertake the phenotypical and functional characterization of teleost B lymphocytes based on the hypothesis that they do not behave as mammalian B2 cells (conventional B cells) but closely resemble mammalian innate B1 lymphocytes involved in extrafollicular T-independent (TI) responses. Since then, my laboratory has gathered considerable evidences that strengthen this hypothesis. These studies were mostly carried out in central lymphoid compartments, but did not address how teleost B1-like cells regulate the delicate balance between immunity and tolerance at mucosal interfaces, in species lacking follicular structures. In this new project, I want to pursue my studies on B lymphocyte functionality, focusing on how teleost mucosal B cells are regulated, still under the assumption that fish B lymphocytes resemble better a B1 model. We will study how fish B cells differentiate to antibody secreting cells (ASCs) and establish extrafollicular long-term memory, taking into account novel results in mammals that have challenged traditional paradigms and revealed that long-term immunological memory can be established through TI IgM B1-like responses. Furthermore, we will also study the role of IgD in the gills, as previous studies from my group suggest that this Ig plays a key role in the regulation of immunity in this specific mucosa, as it seems to do in humans in areas such as the upper respiratory tract.Addressing how fish B cells mount a protective mucosal immune response in the absence of T cell help from organized follicles could provide new mechanistic insights into IgM and IgD responses emerging in humans. From a practi