RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Understanding microbe-induced stomach cancer – the key to a workable strategy for worldwide prevention'.

assistant: **Objectives**

Stomach cancer is the 4th most common cancer and 2nd leading cause of cancer-related death worldwide. The aim of this proposal is to deepen the understanding of mechanisms involved in microbe-induced gastric carcinogenesis, which will facilitate risk stratification for identification of high-risk groups and may offer new opportunities for pharmacological and probiotic prevention. We hypothesize that novel H. pylori genotypic variation can predict carcinogenicity. The cancer-causing H. pylori strains may no longer be present at the time of cancer diagnosis, displaced by a changed microenvironment and invading microorganisms. We further hypothesize that the composition of invading microorganisms determines the risk of stomach cancer. To test these hypotheses, we will perform a case-control study nested within a historic cohort of patients with gastric biopsies taken decades ago. For cases who developed stomach cancer several years after index biopsy and their matched controls, paraffin-embedded blocks will be retrieved for metagenomic analysis of H. pylori and other microfloras, using our new method with laser capture micro-dissection, DNA amplification and sequencing. Interactions of host response and environmental exposures with the gastric microbiome will also be checked. To explore the molecular mechanism underlying the gastric carcinogenesis, we will further examine gastric epigenetic changes and mutation profiles by novel methods which require minute amount of starting material. Moreover, we will develop non-invasive tests for infections with carcinogenic strains of H. pylori and other microorganisms, which can easily be deployed in low-resource countries. This project will not only contribute significantly to reducing the worldwide burden of this dreaded malignancy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Enhanced Place Finding (EPF) of TB transmission hotspots' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

TB is transmitted via person-to-person aerosols. Recent studies suggests that in TB endemic areas up to 70% of transmission events take place outside the household in public places. Moreover, TB transmission is unequally spatially distributed and occurs in transmission hotspot areas. Mathematical models consequently demonstrated that identifying hotspots and blocking within-hotspot-transmission through targeted public health interventions will be the most efficient way of lowering the TB burden. In the present PoC proposal we aim to complement the population-based Enhanced-Case-Finding intervention tested in the INTERRUPTB study, with a spatially more targeted “Enhanced-Place-Finding” (EPF) approach to identify transmission hotspots in an unbiased fashion. Using traditional methods to find transmission hotspots can only be done retrospectively after years of data collection. Therefore we propose a novel EPF strategy to detect transmission hotspots in real-time using phone-tracking technology to establish a spatial map of aggregated TB patients movements. Within the ERC-funded INTERRUPTB study in The Gambia, we sequenced 2000 mycobacterial isolates, which allows us to establish a bacterial genetic transmission network. Within the PoC proposal, we seek to reconsent these patients to analyze their everyday movements using classical contact investigation complemented by phone tracking, to determine which public places have an increased risk of TB transmission. We aim to demonstrate that phone tracking of TB patients can be a cheap, easy, and, most importantly, prospective TB transmission hotspots identification tool, no longer requiring molecular epidemiological investigations. Such a finding can ultimately be developed into an app that warns national TB programs of early T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Conference on the European Innovation Agenda'.

assistant: **Objectives**

This high-level conference will gather public and private representatives from the national, European and international innovation ecosystem to discuss how to Improve Policy Making Tools in line with the 5th flagship of the New European Innovation Agenda. The conference will help to amplify political messages on the need for sustained investment in core capabilities to turn scientific knowledge into business, based on examples of European partners.


**Keywords:** innovation, deep-tech, start-up
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Boltless assembling Of Primary Aerospace Composite Structures'.

assistant: **Objectives**

The main challenge of the BOPACS project is to reduce the weight and costs of primary aerospace structures by developing bolt free adhesive bonded joints that comply with the airworthiness requirements.Until today thin walled composite primary aerospace structures are joined by using a large number of fasteners. Bolt free joining would considerably contribute to the weight and cost reduction of aerospace structures.Within BOPACS target applications will be selected that are commonly used in today’s aerospace primary structures and where adhesive bonding might advantageously replace conventional riveting / fastening. Based on these target application bolt free adhesive bonded joining methods will be developed that comply with the EASA airworthiness requirements.Contrary to projects focusing on the development of non destructive techniques for the inspection of weak bonds, BOPACS proposes arigorous road map to certification by developing Means of Comply based on:•Thorough research, beyond the state of the art, into the crack growth / disbond extension mechanisms in adhesively bonded joints.•Design, analysis, testing and assessment of different categories of crack stopping design features, i.e. features that are capable of preventingcracks or disbonds from growing above a predefined acceptable size, with a joint still capable of carrying the limit load.The project results and certification issues will be reviewed on a regular base by EASA representatives through the Airbus certification department.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'High powEr density FC System for Aerial Passenger VEhicle fueled by liquid HydrogeN' to be submitted under Horizon 2020.

assistant: **Abstract**

The main goal of HEAVEN project is to design, develop and integrate a powertrain based on high power fuel cell and cryogenic technology into an existing 2-4 seats aircraft for testing in flight operation. Specifically, the project proposes to design a modular architecture with modular systems that can be scale-up to other sizes of aircrafts and UAV applications. The design methodology is complemented with safety and regulation analysis. Regarding the fuel cell technology, two high power PEM fuel cell systems of 45 kW based on metallic bipolar plates will be adapted for aircraft applications and integrated with optimized balance of plant components to obtain an enhanced 90kW fuel cell system able to propel without support of a battery the aircraft operating modes. The hydrogen storage will be based on cryogenic technology successfully applied in previous space applications in order to achieve a gravimetric index of about 15% for a hydrogen payload between 10 and 25 kg that provides an autonomy range to the demonstrator of 5-8 hours. Moreover, HEAVEN project will leverage existing drivetrain components and an aircraft demonstrator in order to achieve an overall and successful TRL6 at the end of the project. The technology developments will be enriched with economic and business assessments during the execution of the project. Thus, HEAVEN will produce estimations of a total cost of ownership for the entire life cycle of the technology and business plan for the deployment of the technology in different aeronautics applications.Finally, HEAVEN consortium comprises large companies, SMEs and well-known research center with a strong experience and knowledge in fuel cell technology development for aeronautic applications that is supported with the participation in previous rele
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'First-in-class beta-catenin inhibitor as treatment for colorectal cancer' under Horizon Europe.

assistant: **Concept**

With more than 1.9 million new cases and 935,000 related deaths in 2020, colorectal cancer (CRC) is the third most common cancer in men and the second in women. While surgery is the main treatment option for lower grade CRC, patients with unresectable lesions are treated with chemotherapy. Related therapies are associated with severe drawbacks, such as systemic toxicity, low response rate, and unpredictable resistance. Molecular targeted therapies have emerged as a promising strategy to specifically target cancer cells. For CRC, the inhibition of the Wnt signalling pathway has moved into the focus of novel therapeutic approaches as it is hyperactivated in 80% of all cases. Within the pathway, the protein beta-catenin is considered a particularly attractive target. However, classic small molecule targeting strategies have failed to provide any approved drugs that inhibit beta-catenin so far.We have identified a family of peptidomimetic agents that bind beta-catenin and inhibit its interaction with the TCF/LEF transcription factors. For the first time, it was possible to obtain a crystal structure of a synthetic molecule bound to a therapeutically very attractive site on beta-catenin. In addition, we have confirmed cellular activity of these inhibitors verifying selective inhibition of the Wnt signalling pathway. These findings provide the ideal starting point for the development of novel therapeutics for Wnt-dependent cancers, in particular for CRC. These first-in-class inhibitors will provide the basis for the development of therapeutics that selectively inhibit oncogenic Wnt signalling thereby affecting the viability of corresponding cancer cells. This can enable targeted therapies for Wnt-dependent forms of CRC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Classicising learning in medieval imperial systems: Cross-cultural approaches to Byzantine paideia and Tang/Song xue' (PAIXUE), addressing dissemination and exploitation.

assistant: **Impact**

In the medieval Eurasian geopolitical space, Byzantium and China stand out as two centralised imperial orders that drew on seemingly unbroken, in fact purposely constructed, traditions of classicising learning. PAIXUE examines in tandem, with equal focus on structural parallels and divergences, the conscious revival and subsequent dialectics of classicising learning in middle and later Byzantium (c.800–1350) and Tang/Song China (618–1279). Initially tied into aristocratic culture, it became a tool by which the imperial state sought to monopolise prestige and access to power so as to effectively channel the activities of newly emerging burgeoning ‘middling’ strata into the service of empire. As time progressed, it was also the basis upon which these new elites constructed novel forms of subjectivity that claimed authority and agency increasingly independent of the imperial state.PAIXUE traces this evolution of classicising learning in Byzantine and Tang/Song literati culture from two angles. The rst examines the galvanising function of social performances that involved classicising learning in the imperial systems. The second places the individual literatus centre-stage and explores the transformations of self-awareness, ethos, and self-cultivation. Given PAIXUE’s concern with examining phenomena cross-culturally in the longue-durée, rather than merely juxtaposing ‘spotlight’ impressions, a comparison of these two imperial systems does not only allow for deeper insights into the historical development of both China and Byzantium: it opens the possibility of studying cultural mechanisms behind the formation of institutions, practices and values. The project explores novel forms of collaboration in the humanities, including the co-authoring of research output between Byzan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Green Product Development and Resource Efficient Production Assigned Training in St. Petersburg area, Russia' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Russia faces a strong demand for modernisation and greening of their industrial sectors. Life Cycle Analysis(LCA) is a well-tested methodology to assess the environmental impact from production processes and from these of the products. In Russia there is a need for both theoretical and practical training of the target groups(researchers, governmental people and industrial companies) to increase the building capacity for technologytransfer.One of the core activities in this project is therefore such a training programme on LCA, cleaner production and green product development in the St. Petersburg region. The methodology will be implemented in at least ten manufacturing companies and will build up a local capacity for LCA and green product development. The aim is to demonstrate, in full scale, solutions minimising the environmental emissions from the production and from the use of the product in a sustainable way. This will be achieved by demonstrating the methodology in three pilot cases for different companies. Results of the project will also be presented for a larger number of stakeholders and spread to other regions.Thiswill give a base for improvements in the Russian industrial production in the St. Petersburg region towards sustainable development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Relationships between secondary sexual characters and health status in tits'.

assistant: **Objectives**

Research objectives and content Assessment of sexual selection has grown to be one of the most active areas of study in evolutionary biology. Although some studies have recognized that 'bright' males are more resistant to parasites, the relationships between secondary sexual characters and health have been poorly investigated and the physiological mechanisms responsible for the production of these characters have also been largely ignored. In this project, the relationships between male 'brightness' (measured by song and plumage characteristics) and the resistance to parasites will be studied by several complementary approaches, both empirical and experimental. Using blue (Parus caeruleus) and great tits (P. major) as model species, we will examine 1) the relationship between 'brightness' and parasite loads 2) the relationship between 'brightness' and immuno-competence, 3) the role of testosterone in linking 'brightness' and immuno-competence, 4) the relationship between 'brightness' of the male and the resistance to parasite of its offsprings. This multi-disciplinary approach will provide a better understanding of the function and evolution of secondary sexual characters. Training content (objective, benefit and expected impact) The objective of the training is to complete the education of the applicant in evolutionary ecology and especially in host-parasite interactions related to sexual selection. The applicant will be able to learn behavioural techniques (sound analysis) as well as techniques of immunology and endocrinology. Exchange of ideas and techniques between researchers of a multi-disciplinary team will not only create a stimulating and instructive environment for the applicant, but is also necessary to obtain new important insights. The training will broaden
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Open-Source Cloud-Based Services on EPI Systems' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

This project proposes to design OpenCUBE, a full-stack solution of a validated European Cloud computing blueprint to be deployed on European hardware infrastructure. OpenCUBE will develop a custom cloud installation with the guarantee that an entirely European solution like SiPearl processors and Semidynamics RISC-V accelerators can be deployed reproducibly. OpenCUBE will be built on industry-standard open APIs using Open Source components and will provide a unified software stack that captures the different best practices and open source tooling on the operating system, middleware, and system management level. It will thus provide a solid basis for the European cloud services, research, and commercial deployments envisioned to be core for federated digital services via Gaia-X. To remain competitive for the European Green Deal, OpenCUBE is designed to make energy awareness a core feature at all levels of the stack, exploiting the advanced features of the SiPearl Rhea processor family at the hardware level and exposing the necessary API at the site level, up to and including interfaces to the electricity grid. This project will leverage representative workloads like those of ECMWF characteristics for production and Digital Twin workflows as drivers for the design and deployment of the cluster infrastructure. We will collaborate closely with the projects developing the virtual environments and the open hardware interfaces for current and future European processor and coprocessor technology.


**Keywords:** Cloud Services, EPI Systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Apolipoprotein E gene in the Metabolic Syndrome' (APOMET) targeting Seventh Framework.

assistant: **Abstract**

Metabolic Syndrome (MetS) is closely linked to disturbances in lipid and glucose metabolism and increases the risk of developing cardiovascular disease and diabetes. One-fourth of the adult European population has the MetS and a further increase is anticipated because a greater prevalence of obesity in the future. Apolipoprotein E (APOE) associates with lipoproteins and mediates theirmetabolism. In humans, the APOE gene is polymorphic and has three alleles, APOE*2, APOE*3 and APOE*4. Carrying the APOE*4 allele has been associated with an increased cardiovascular risk, predisposition to develop Alzheimer’s disease and insulin resistance. Recently, APOE*4 has also been linked with MetS. However, the mechanisms whereby this association occurs are not clear. The objective of thisproject is to investigate the role of APOE in metabolic syndrome. We hypothesize that APOE*4 presence determines a less flexible metabolism; i.e. an inability to effectively switch between lipids and carbohydrates for fuel and the subsequent carbohydrate intolerance.For our Work Package 1 we will employ mice whose endogenous Apoe gene has been replaced by the human APOE*3 or APOE*4 allele. We will investigate the energy substrate handling of these “humanized” mice at the whole body level by using metabolite tracers and diverse “-omics”, which will reveal why the energy generating pathways differ with apoE-isoform presence. At the population level, Work Package 2 will identify human APOE*4 carriers and investigate new APOE genetic variants to determine whether the association between APOE-isoform and metabolic syndrome is diet-dependent in the participants of the Aragon Workers Health Study, an ongoing longitudinal study targeted to study the appearance and progression of cardiovascular risk factors.