RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Mechanisms of human co-translational quality control and it’s role in neural tissue.'.

assistant: **Innovation**

Ribosome-associated quality control (RQC) is crucial for degrading truncated nascent proteins produced on aberrant mRNAs. This is done by elongation of the nascent chain on the large ribosomal subunit in the absence of mRNA and the small ribosomal subunit (CAT tailing) and by marking the nascent chain for degradation. Mutations in RQC components cause neurodegeneration both in animal models and human patients. Moreover, RQC insufficiency and subsequent protein aggregation critically contribute to proteostasis impairment and systemic decline during ageing. Strikingly, we lack mechanistic understanding of this crucial process in humans.This project stems from my post-doctoral research, in which I have solved the structure of the yeast RQC complex and discovered a novel RQC factor, the eIF5A. This conserved protein is critical in yeast RQC and was recently implicated in brain development and Huntington's disease. Moreover, I have developed a human cell-free translation extract, which enables structural studies of co-translational processes in the human system. In the proposed research, we will provide mechanistic understanding of CAT tailing and nascent chain degradation in human RQC using cryo-EM. We will define working principles of RQC components and the mechanisms by which their disease-causing mutations specifically affect neurons in vivo using the C. elegans as a model organism.Our approach utilizes a multidisciplinary approach to provide detailed mechanistic understanding of the critical RQC system in combination with an in vivo study to reveal processes leading to RQC-driven pathological changes in neural tissue. Since the RQC pathway is conserved in all kingdoms of life and serves a pivotal role in protein homeostasis with critical implications for neurodegenerati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Black Hole Stability Problem and the Analysis of asymptotically anti-de Sitter spacetimes' (BHSandAADS) under Horizon 2020.

assistant: **Objectives**

The present proposal is concerned with the analysis of the Einstein equations of general relativity, a non-linear system of geometric partial differential equations describing phenomena from the bending of light to the dynamics of black holes. The theory has recently been confirmed in a spectacular fashion with the detection of gravitational waves.The main objective of the proposal is to consolidate my research group based at Imperial College by developing novel mathematical techniques that will fundamentally advance our understanding of the Einstein equations. Here the proposal builds on mathematical progress in the last decade resulting from achievements in the fields of partial differential equations, differential geometry, microlocal analysis and theoretical physics. The Black Hole Stability ProblemA major open problem in general relativity is to prove the non-linear stability of the Kerr family of black hole solutions. Recent advances in the problem of linear stability made by the PI and collaborators open the door to finally address a complete resolution of the stability problem. In this proposal we will describe what non-linear techniques will need to be developed in addition to achieve this goal. A successful resolution of this program would conclude an almost 50-year-old problem. The Analysis of asymptotically anti-de Sitter (aAdS) spacetimesWe propose to prove the stability of pure AdS if so-called dissipative boundary conditions are imposed at the boundary. This result would align with the well-known stability results for the other maximally-symmetric solutions of the Einstein equations, Minkowski space and de Sitter space. As a second -- related -- theme we propose to formulate and prove a unique continuation principle for the full non-linear Einstein equati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Causes, Processes, and Effects of Subsurface Sediment Mobilisation on Reservoir to Regional Scale'.

assistant: **Objectives**

The aim of the conference is to document and discuss all aspects of subsurface sediment deformation within large shale sequences. Such deformation includes soft sediment deformation at shallow burial depth, mobilisation of over pressured shale in shale diapirs, injection of clastic dykes and sills, expulsion of material in mud volcanoes. This deformation may occur in response to sedimentary loading, overpressure increase or diagenetic alterations and is commonly influenced by the regional tectonic stress regime. Large-scale deformation often controls the structural style and fluid dynamics of the sedimentary basin whereas on a smaller scale reservoir properties are severely affected by rost-depositional sediment mobilisation and the sealing capacity of clay for hydrocarbon reservoirs or for long-time storage of hazardous waste may change risks to be misjudged.Although the research areas in the above list seem very diverse they are in fact several aspects of one large topic: the deformation within shale sequences with varying internal and external pressure. Different aspects of this topic are relevant to different research communities and are studied using different techniques, leading to extreme specialisation. Mainly because of lack of comparable data there has been little exchange between the different disciplines, relevant information is dispersed and the topic is surpisingly poorly understood. Over the last years, the resolution of techniques to image and study the subsurface has improved tremendously, which generated much new detailed data of comparable resolution. Moreover, detailed studies of clay deformation and mobilisation (e.g. discontinuities in clays for waste storage) yielded a wealth of new data that cannot be interpreted according to the classical theore
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Homogeneous Structures, Constraint Satisfaction Problems, and Topological Clones', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The complexity of constraint satisfaction problems (CSPs) is a field in rapid development, and involves central questions in graph homomorphisms, finite model theory, reasoning in artificial intelligence, and, last but not least, universal algebra. In previous work, it was shown that a substantial part of the results and tools for the study of the computational complexity of CSPs can be generalised to infinite domains when the constraints are definable over a homogeneous structure. There are many computational problems, in particular in temporal and spatial reasoning, that can be modelled in this way, but not over finite domains. Also in finite model theory and descriptive complexity, CSPs over infinite domains arise systematically as problems in monotone fragments of existential second-order logic.In this project, we will advance in three directions:(a) Further develop the universal-algebraic approach for CSPs over homogeneous structures. E.g., provide evidence for a universal-algebraic tractability conjecture for such CSPs.(b) Apply the universal-algebraic approach. In particular, classify the complexity of all problems in guarded monotone SNP, a logic discovered independently in finite model theory and ontology-based data-access.(c) Investigate the complexity of CSPs over those infinite domains that are most relevant in computer science, namely the integers, the rationals, and the reals. Can we adapt the universal-algebraic approach to this setting?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'REVisiting Antibody structures and repertoires through advances in  Mass spectrometry and Proteomics' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In REVAMP, I will create innovative structural mass spectrometry (MS) and proteomics techniques to generate an unprecedented molecular understanding of the diversity and structural and functional characteristics of human antibody repertoires. These repertoires are highly personal and play a key role in our human immune response.Recently, my research has taken a novel challenging avenue, with a focus on the development of cutting-edge MS-based techniques to better understand antibody structure and function. With these methods, I have started to monitor at the protein level (changes in) endogenous antibody repertoires with clonal resolution, including those induced by antigen-specific polyclonal responses in individuals. Early studies were limited to IgG1, and in REVAMP, I aim to expand the toolbox to the full antibody repertoire, including all (sub)classes of antibodies. I aim to learn how and why antibody profiles in serum, and other body fluids, are alike or distinct, investigating structural, clonal and functional differences over time and between individuals. I will develop technologies to target the sub-repertoires recognizing antigens from pathogens. Following identification by advanced top-down and bottom up de novo sequencing these antibodies will be followed up functionally as potential therapeutic leads.Special attention will be given to IgM, the largest human antibody, appearing first in the response to an antigen. We recently made the preliminary striking observation that its structure is ill-defined in textbooks, and that human IgM may be quite different from IgM in other mammals. This project will benefit from our recent advances in structural analysis by single molecule mass spectrometry, mass photometry, atomic force microscopy and electron microscopy. RE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Critical Raw materials Elimination by a top-down Approach To hydrogen and Electricity generation' (CREATE), addressing dissemination and exploitation.

assistant: **Impact**

CREATE aims at developing innovative membrane electrode assemblies for low-temperature polymer-electrolyte fuel cell (FC) and electrolyzer (EL) with much reduced cost. This will be achieved via elimination or drastic reduction of critical raw materials in their catalysts, in particular platinum group metals (PGM).Key issues with present low-temperature FC & EL are the high contents of PGM in devices based on proton-exchange-membrane (PEM) and the need for liquid electrolytes in alkaline FC and EL. To overcome this, we will shift from PEM-based cells to 1) pure anion-conducting polymer-electrolytes and 2) to bipolar-membrane polymer electrolytes. The latter comprises anion and proton conducting ionomers and a junction. Bipolar membranes allow adapting the pH at each electrode, thereby opening the door to improved performance or PGM-free catalysts. Both strategies carry the potentiality to eliminate or drastically reduce the need for PGM while maintaining the advantages of PEM-based devices.In strategy 1, novel anion-exchange ionomers and membranes will be developed and interfaced with catalysts based on Earth-abundant metal oxides or metal-carbon composites for the oxygen reactions, and with ultralow PGM or PGM-free catalysts for the hydrogen reactions.In strategy 2, novel bipolar membrane designs, or designs unexplored for FC & EL, will be developed and interfaced with catalysts for the oxygen reactions (high pH side of the bipolar membrane) and with catalysts for the hydrogen reactions (low pH side). The ionomers and oxygen reaction catalysts developed in strategy 1 will be equally useful for strategy 2, while identified PGM-free and ultralow-PGM catalysts will be implemented for the hydrogen reactions on the acidic side.Polymer-electrolyte FC & EL based on those conce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'EXploring Photoinduced Enzyme pRomIscuity in the Glucose-Methanol-Choline oxidoreductase family to dEvelop New phoTocAtaLysts'.

assistant: **Innovation**

Photoenzymes are rare biocatalysts that use the energy contained in photons to perform chemical reactions. To date, only one natural photocatalyst is known to have biotechnological applications; the Fatty Acid Photodecarboxylase (FAP), allowing the production of hydrocarbons from fatty acids. FAP belongs to a superfamily of enzymes called Glucose Methanol oxidoreductases (GMCox). Still, the FAP group is the only one known to perform photochemistry despite the high degree of structural similarity and presence of a photosensitive cofactor, Flavine Adenine Dinucleotide (FAD), in all GMCox.     We reason that the GMCox family could have a latent photochemical function, and we would like to exploit it. Therefore, the objective of this project is to EXplore Photoinduced Enzyme pRomIscuity in the Glucose-Methanol-Choline oxidoreductase family to dEvelop New phoTocAtaLysts (EXPERIMENTAL). To this end, we will first test the photoinduced substrate promiscuity with different GMCox using an “accelerated serendipity” approach. In a second step, we will optimize the newly discovered photoenzymatic activity by directed evolution. Finally, the enzymatic mechanism will be characterized using different biophysics approaches, ranging from time-resolved spectroscopy to serial femtosecond crystallography.     This project is inherently interdisciplinary, combining chemistry, biochemistry and biophysics to develop new photocatalysts for biotechnological purposes. For fundamental research these new photoenzymes will be an opportunity allowing the study of ultrafast processes that occur during catalysis and can only be observed with light-dependent enzymes such as electron and/or proton transfer, bond breaking ect.     In fine, the goals of EXPERIMENTAL are to provide a better appreciation of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Pan-European Urban Climate Services'.

assistant: **Concept**

Urban areas are very vulnerable to climate change impacts, because of the high concentration of people, infrastructure, and economic activity, but also because cities tend to exacerbate climate extremes such as heat waves and flash floods. The objective of the Pan-European Urban Climate Service (PUCS) project is to establish a service that translates the best available scientific urban climate data into relevant information for public and private end-users operating in cities. This will be achieved by demonstrating the benefits of urban climate information to end-users, considering the sectors of energy, cultural heritage, mobility, energy, health, and urban planning. During the first half of the 30-month project, end-users (included as partners) and climate service providers will be involved in the co-design/-development of six concrete sectoral cases, to be implemented in Antwerp, Barcelona, Bern, Prague, Rome, and Vienna. Each of these cases will be subject to a detailed socio-economic impact analysis, quantifying the benefits of using urban climate information. The second half of the project will focus on upscaling and market replication, initially aiming at the extension with six new cases, involving new (non-financed) end-users. Through a business development strategy, supported by dissemination and marketing activities, we ultimately aim at acquiring six more cases by the end of the project, involving new business intermediaries without PUCS project financing, and demonstrating the long-term market viability of the service. PUCS aims at a genuine market uptake of (urban) climate services, based on a distributed network of local business intermediaries throughout Europe, enhancing the awareness for urban climate-related issues in the end-user community, and conver
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'AUTONOMOUS PV IN AGRICULTURE AND WATER MANAGEMENT' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

To demonstrate the technical and economical potential of autonomous PV systems for agriculture and water management in Europe. 56 stand alone PV systems, each rated at approximately 1400 Wp, giving a total PV power for the project of 81 kWp will be demonstrated in 5 countries of the EU. The PV systems will provide power for pumping of animal drinking water, lighting, aeration of fishponds, and small scale water management for irrigation.56 stand alone PV systems for various applications, taylored for each specific purpose. Installation shall be completed by January 1998, with a two year monitoring phase starting in January 1997. An estimated electricity production of 45000 kWh/year is expected.Subsystem applications (examples) : fish pond aeration, remote shed, greenhouse, pig sty, stables, alpe cabine, waterpumping (irrigation)Nr. subsystems : 56Power subsystems : 1.45 kWp typically (0.5...2.0 kWp)Total power : 81 kWpBackup : fuel generators or small cogeneration plants, one wind generatorBattery : different sizesBattery capacity (kWh) : 0 or 3...20 kWhInverter : different sizes in some systemsInv. power (kW) : 0 or 1...4 kWLoad description : various applications in different systemsMonitoring :
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Pre-normative research on safe indoor use of fuel cells and hydrogen systems'.

assistant: **Objectives**

This project addresses the issue of safe indoor use of hydrogen and fuel cells systems (priority 4.6 of the call FCH-JU-2010-1) for early markets (forklift refuelling and operation, back-up power supply, portable power generation, etc.): It aims to provide scientific and engineering knowledge for the specification of cost-effective means to control hazards specific to the use of hydrogen indoors or in confined space and developing state-of-the-art guidelines for European stakeholders.Specific knowledge gaps need to be closed in the areas of indoor hydrogen accumulations, vented deflagrations, and under-ventilated jet fires. A focus on foreseeable release conditions for fuel cell systems in the prescribed power range and enclosure characteristics related to early markets will feed the precise formulation of analytical, numerical and experimental studies to be performed in the project.The generated knowledge will be described in the state-of-the-art safety guidelines including contemporary engineering tools and recommendations to provide safe introduction of fuel cells and hydrogen in early markets.The recommendations will be formulated for integration into ongoing or new Regulations Codes and Standards activities to be implemented at national and international levels.The consortium includes key players in the field comprising industry (Air Liquide, HFCS), research organisations (CEA, KIT-G, HSL, JRC, NCSRD), academia (UU), and an actor in RCS development (CCS Global Group).The outputs of the project will be disseminated to the hydrogen safety community through different channels including international and national associations (IA-HySafe, EHA, EIGA, etc.), standard development organisation (ISO, CEN, etc.), national regulators (e.g. HSE/HSL in the UK) and educational/tr