RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'trAining younG researchers On shaping MetaveRse for business and social vAlue (AGORA)' in the context of a Horizon Europe call.

assistant: **Objectives**

As metaverses operate in real-time their wide adoption is expected to create digital public spaces for interaction in which the already possible online interactions are intensified and blended with the physical world as never before. To lead in this field and maximize positive implications, Europe needs to ensure that new multi-dimensional challenges arising, are addressed in accordance with European values. AGORA responds to the lack of doctoral programs which go beyond the technical understanding of Metaverses and consider its business and social value while unpacking and addressing potential unintended consequences. Through a rigorous and robust research and training programme, AGORA aims to develop a critical research and talent base capable of leading by example.  AGORA’s approach is to train the researchers not only to understand Metaverse's infrastructure but also to understand and oscillate between the different levels of Metaverse’s business and societal value, paving in this way a more integrated understanding of this disruptive ecosystem. Combining theoretical and hands-on industrial research and transferable skills training will enable researchers to target high-quality publication outlets and to become creative and autonomous so that they can exploit and commercialize research results and become competitive in the global arena. One of AGORA’s unique selling points is its ability to prepare the ESRs to work in any of the three pathways (academia, industry, policy making) as well as their intersections. AGORA's inter-sectoral network brings together leading academic and non-academic co-supervision arrangements of high quality, stimulates the development of new industrial doctoral training procedures between top business schools and industries in the region.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Metagenomics in Cardiometabolic Diseases' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

METACARDIS applies a systems medicine multilevel approach to identify biological relationships between gut microbiota, assessed by metagenomics, and host genome expression regulation, which will improve understanding and innovative care of cardiometabolic diseases (CMD) and their comorbidities. CMD comprise metabolic (obesity, diabetes) and heart diseases characterized by a chronic evolution in ageing populations and costly treatments. Therapies require novel integrated approaches taking into account CMD natural evolution.METACARDIS associates European leaders in metagenomics, who have been successful in establishing the structure of the human microbiome as part of the EU FP7 MetaHIT consortium, clinical and fundamental researchers, SME, patients associations and food companies to improve the understanding of pathophysiological mechanisms, prognosis and diagnosis of CMD.We will use next-generation sequencing technologies and high throughput metabolomic platforms to identify gut microbiota- and metabolomic-derived biomarkers and targets associated with CMD risks. The pathophysiological role of these markers will be tested in both preclinical models and replication cohorts allowing the study of CMD progression in patients collected in three European clinical centres of excellence. Their impact on host gene transcription will be characterised in patients selected for typical features of CMD evolution. Application of computational models and visualisation tools to complex datasets combining clinical information, environmental patterns and gut microbiome, metabolome and transcriptome data is a central integrating component in the research, which will be driven by world leaders in metagenomic and functional genomic data analysis. These studies will identify novel molecular ta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Synthesis of Multi-Silencing Polymerized RNA Nanoparticles for Enhanced Cardiac Transdifferentiation via Microneedle Delivery' in the context of a Horizon Europe call.

assistant: **Objectives**

My research aims to advance drug delivery by developing multi-silencing polymerized RNA nanoparticles (Multi-R-NPs) for customized treatments across a wide range of diseases, using engineered microneedles to enhance efficacy. This versatile platform can be adapted for applications such as stem cell differentiation and biosensing, with immediate potential to treat fibrotic diseases like cardiac and pulmonary fibrosis, reducing preventable mortality and improving patient quality of life. Therapeutic transdifferentiation of cardiac fibroblasts into induced cardiomyocyte-like cells could address the limitations of conventional cardiac fibrosis therapies, which typically only manage symptoms and do not prevent the progression of the disease. However, current transdifferentiation strategies face challenges such as low transfection efficiency, uncontrolled gene expressions, and immune responses to viral vectors. This proposal aims to develop multi-silencing polymerized RNA nanoparticles (Multi-R-NPs) through rolling circle transcription (RCT) to enable unique combination therapies that synergize multiple nucleic acid therapeutics. Moreover, to minimize the side effects of untargeted delivery and overcome barriers to cardiac delivery, we will use microneedles to enable local Multi-R-NP transfection. I anticipate that combining two state-of-the-art technologies, RCT and microneedles, will enable the delivery of synergistic nucleic acid therapeutics and promote more optimal cardiac repair through efficient transdifferentiation. During my fellowship at the University of Oxford in Professor Dame Molly Stevens’ lab, I will apply precise control polymerization of therapeutic RNAs and formulate multi-layered polyplex structures. The strong collaborative networks with the British Heart
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a Micro-Machined Mass Spectrometer (MMS)' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Mass Spectrometry is a widely used teehnique for the qualitative and quantitative analysis of gases and vapours. It is a particularly attractive technique for many applications because it provides fast on-line information derived from the measurement of fundamental properties (i.e. atomie and molecular mass). Applieations for mass spectrometers are growing rapidly, particularly in high technology manufacturing (microelectronies industry), chemical analysis and environmental monitoring. Unfortunately, mass spectrometers are usually weighty and bulky and cannot therefore be used for certain important requirements. The objective of the MMS project is to conceive a miniaturise mass spectrometer, calculate its physieal properties through the use of software simulation teehniques and apply recent advances in miero-maehining technology, to design and develop a Micro-machined Mass Spectrometer ('mass spectrometer on a chip'). The development of a small geometry mass spectrometer deviee should make the technology more compatible with many industrial applications because such a device would: - Be easier to integrate into a production tool (as an in-situ process monitor) - Function at higher pressures than existing mass spectrometers which require high vacuum (the ability to operate at higher pressures will eliminate the need for bulky and costly high vaeuum pumps) Should the project consortium succeed in conceiving, designing and fabricating a working MMS device then this device will be characterised and optimised to enhance important performance parameters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Non-equilibrium statistical mechanics of granular materials'.

assistant: **Objectives**

A numerical and analytical study of the fluctuations of injected power, internal energy/heat currents and other transport observables in realistic and simplified models of fluidized granular matter is proposed. Fluidized granular matter is the class of sys tems made of many grains (from sand to seeds and pills) under a continuous external driving, such as violent shaking of the container. At high fluidization the behavior of such a vibrated granular system resembles that of a gas with inelastic collisions. A granulas system becomes, therefore, the perfect istance of non-equilibrium statistically statitionary system, where the stationarity results from the balance of injected energy and heat dissipated in collisions. Recent experiments have suggested that in a a granular gas a relation similar to the Gallavotti-Cohen Fluctuation Theorem is valid. Some more recent work has shown that false verification of the Fluctuation Theorem are extreme likely to appear in experiments and in numerical simulations, because of the limited range available in the statistics of measured observables. This project aims to study in detail the statistical properties of injected power and internal energy/heat currents and at the same time find a definition of entropy production which c an be suitable for experimentable situations. This ambition is relevant for the whole theory of non-equilibrium statistiscal mechanics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Real-time mammalian retina models' to be submitted under Sixth Framework.

assistant: **Abstract**

It has become a standard medical procedure to replace lost body functions with prostheses. Recently some form of visual sensation has been restored in blind patients with the help of retinal implants. Retinal implants use electronics to stimulate retinal g anglion cells based on information recorded with a video camera.It has been known for 50 years that neural circuits in the retina significantly change the space-time properties of the image flow that falls on the photoreceptor cells. Therefore it is desirable to use retinal neural algorithms between the image captured by the video camera and the electronics that stimulate retinal cells.An earlier multi-layer retinal model is far slower than real-time. Based on my experience with retinal modeling in my Ph D thesis lab as well as at the University of California Berkeley and Harvard University my goal is to develop novel spatio-temporal algorithms corresponding to different retinal channels that can be implemented real time.These algorithms are based on state-of-the-art recordings from mammalian retinas. The algorithms use the analog-and-logic cellular wave-computing paradigm called Cellular Nonlinear Networks that was co-invented by my former PhD supervisor.The collaboration with Seville, Spain and two Berkeley, CA laboratories led to existing silicon chips. These chips are integrated into an industrial high-speed camera computer, called Bi-I that was awarded the title `Product of the year at Vision 2003 in Stuttgart.During my postdoctoral training I plan to learn neurobiological methodologies to complement my current engineering knowledge including patch clamping, imaging and confocal microscopy. The host neurobiology laboratory is uncovering the retinal circuit details: Friedrich Miescher Institute, Basel.The project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A real time system for quantitative diagnostic pathology and visualisation in 3D' (3D-PATHOLOGY).

assistant: **Innovation**

The 3D-PATHOLOGY proposal addresses a long acknowledged need for quantification of parameters in pathology. The principal objectives of the proposal are: using real-time embedded technologies, to develop a system which is capable of increasing diagnostic and prognostic accuracy. This is done by accumulating a colour 3D image of cells or tissue in microscopic resolution within the computer, and subsequently to expose the synthesised image to full colour quantitative image analysis, thus obtaining valuable information about the material in hand. Also intuitive ways of visualising 3D images are considered. Potential applications to be tested in the project: cervical cytology, cytological diagnosis of body cavity effusions, urine cytology, fine needle aspiration cytology (FNAC), immunocytochemical stains.OBJECTIVESThe principal objective of the 3D-Pathology proposal is to create a new real time system for pathologists that makes it possible to decrease the diagnostic and prognostic error rate. This will be done by creating digital 3D light microscopy images for subsequent visual inspection and quantitative colour image analysis. To develop ways of visualising 3D images in order to heighten the level of insight to the pathologist. Technological highlights: As a result of the development work the following features are envisaged to be made possible: ?Resolution of cell clusters and tissue components?, ?The proper 3D extension of objects can be resolved?, ?True 3D colour image algorithms can be applied?, ?Virtual reality: The surroundings of a selected image object can be made transparent making it possible to view the object from any camera angle?, ?The ?software microscope? can be applied to the digital image?DESCRIPTION OF WORKWorkpackages: The project has been broken down
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Vestibular System, Cognition and Vegetative Regulations' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The vestibular system (VS), and more specifically its otolithic part (specialized in detecting gravity and inertial linear acceleration), has long been recognized for its role in spatial orientation and postural equilibrium. Its involvement in the regulation of other physiological systems (respiratory and cardiovascular systems, circadian regulation, food intake, bone mineralization) has been made clear only recently.  Besides an increase in basic scientific knowledge, studying the biological impact of VS is also crucial for space exploration because it could participate in some harmful effects of prolonged exposure to weightlessness - such as cardiovascular and sensory-motor deconditioning, bone loss, and hormonal changes. VS dysfunction could also be implicated in common pathological conditions such as orthostatic hypotension, sleep disruption, bone loss…Studying the biological effects of the otolith system can be performed by removing it or, more physiologically, by changing the level of gravity. Hypergravity can be produced by centrifuges while reduced gravity can only be obtained during parabolic or space flights. There are few ground alternatives, such as head-down bed rest and dry immersion, for studying some aspects of the effect of weightlessness on physiological systems. These facilities are scattered throughout Europe, Russia and the USA and no single scientific team has the expertise in all the main scientific fields relevant to gravitational physiology: neurosciences, musculo-skeletal physiology, endocrinology, chronobiology, and cardiovascular physiology. Thus, ambitious scientific research on the implication of VS in gravitational physiology is not conceivable without international cooperation. The aim of this proposal is to establish long-term research c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A role for nuclear pore complexes in chromatin organization during early development?' (NPCChr) under Horizon 2020.

assistant: **Objectives**

During differentiation, cells undergo large-scale chromatin rearrangement, notably with the establishment of heterochromatin blocks at the nuclear periphery during the epiblast stage of development. Concomitantly, hundreds of genes are relocated to and from the nuclear periphery and their position is correlated with their expression levels. Most of these genes are associated with regulation of pluripotency, suggesting that the association of fLADs to the NL is a key parameter for proper embryonic development. Recent work of the host lab using synthetic activators showed that the chromatin rearrangement is responsible for the relocation of these genes. However, the mechanisms that govern this chromatin rearrangement are largely unknown. Here I propose to test whether a modulation of nuclear pore density allows chromatin reorganization during differentiation of embryonic stem cells (ESCs) into epiblast stem cells (EpiSCs), laying the groundwork for future analysis in vivo during embryonic development. As a complementary approach, I will determine the mechanisms that prevent heterochromatin formation at nuclear pore complexes. The use of state of the art techniques such as super-resolution microscopy, genome mapping and a multidisciplinary approach combining biology and physics will allow me to understand the role of nuclear pore complexes in the regulation of genome organization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Combined Organic LED Technology for Large Area Transparent and low cost lighting Applications' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Solid state lighting is a fascinating research field which brought up the revolutionary breakthrough technology of inorganic LEDs during the last decade. These are now migrating into the general lighting field. A new development route is already identified with organic light emitting devices in large area and nm-thin architectures being complementary to inorganic point sources.These organic light-emitting devices (OLEDs) for lighting purposes are expected to have broad market opportunities due to their out-standing properties. They can act as nearly two dimensional diffuse light sources as well as for signage applications. They have the potential to offer transparency and flexibility paving the way for completely new applications. As efficiencies above 50 lm/W are targeted these novel light sources have also the potential to decrease the global energy consumption.Similar efficiencies and lifetime compared to existing solutions is a prerequisite for new lighting technologies. A staircase improvement from today's level towards 50 lm/W and 5000 h lifetime of large area tiles can be expected which will be sufficient for first niche applications soon.However, an effective market introduction of OLEDs for lighting and signage would become the lighting revolution in the future as soon as:\tthe cost structure is competitive\ta unique selling point like transparency is explored.So one of the major road block" that is still ahead are manufacturing costs: If no breakthroughs in terms of new low-cost processes are made, OLED technology will not enter the market in large volume, even if the performance would allow competing.The second issue to be addressed in CombOLED takes care about the uniqueness of OLED for lighting: Besides the advanced form factor of OLED lighting panels fur