RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Silicon-photonics-based laser spectroscopy platform: towards a paradigm shift in environmental monitoring and health care'.

assistant: **Concept**

The Principal Investigator and his team will open up new horizons in the field of laser spectroscopy through basic research on silicon-photonics-based Spectroscopic Systems-On-Chip (SpecSOC’s). The key question being addressed is: how can the powerful concepts of high-index-contrast nanophotonics be combined with the extreme accuracy of silicon technology and with the performance of hybrid silicon/III-V integration in order to create system-on-chip functionalities for advanced (bio-)spectroscopy.We will first focus research on integrated lasers or Laser Systems-on-Chip (LaSOC’s) capable of providing very wide wavelength tuning in the infrared, mid-infrared or visible. These lasers will have an unprecedented combination of properties. They will differ from existing semiconductor lasers in the sense that they combine the best of III-V semiconductor technology and silicon technology in unique cavity structures exploiting high index contrast in three dimensions.In the second phase of the project we will shift the focus from laser-oriented novelty to spectroscopy-oriented novelty and investigate SpecSOC’s with an unprecedented system performance that matches the requirements of mainstream real-life spectroscopy. We will explore coherent optical detection techniques for sensitivity enhancement, microporous coatings for on-chip gas sensing and implant-oriented tissue spectroscopy.Our research will lead to a paradigm shift in laser spectroscopy, in the sense that it will turn an advanced spectroscopy system into a small form-factor commodity system. This will have an enormous impact on applications such as point-of-care medical diagnosis and medical implants, monitoring of air, water and food quality. Furthermore the on-chip spectroscopy systems will be highly valuable for fund
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Differential demographic behaviour by education and its links with the reproduction of educational inequalities in Europe', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In the last decades, social inequalities within countries and the rise in socio-economic differences between European countries have been an increasing policy concern. Education plays a chief role as a resource to fight poverty and to ensure greater social and territorial cohesion, within and across countries, as recognised by the Europe 2020 strategy. Supporting individuals to achieve tertiary education is a necessary policy-target, however, in the long-term, it may not be sufficient to eradicate educational differences across countries. This is especially due to the links between differential demographic behaviours by educational groups and the intergenerational transmission of education.  Keeping a comparative approach by country and sex, this project aims at highlighting macro-level consequences of the educational gradient in family formation processes and the transmission of tertiary education from one generation to the next one. To this end, I will use the most recent comparable cross-country individual survey-data (SHARE, GGS), and I will apply advanced statistical techniques (i.e., decomposition and simulation methods) that permit to reconcile micro-macro levels of analysis. This project emphasizes the fact that enacting family policies, which aim to flatten the educational gradient in demographic behaviour, is a possible way to reduce educational differences across European countries. Next, I also emphasize the bidirectional relationship between parent-children generations. On the one hand, I focus on the transmission of education from parents to children and, on the other hand, I refer to (potential) feedback effects of children’s education on parents’ survival. Overall, this project will uncover the connections between the fields of demography and social ineq
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of GPER agonists as a novel therapeutic option for pancreatic cancer' under Horizon 2020.

assistant: **Concept**

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is the fourth-leading cause of cancer related mortality and is predicted to be the second leading cause of cancer death by 2030. Widely regarded as a death sentence, the 5-year survival rate is less than 5% and this figure has not changed over the past four decades due to lack of effective therapies. PDAC develops in a fibrotic setting that hampers drug delivery and modulates immune response & tumour growth/dissemination.  Pancreatic stellate cells (PSCs) are the main resident cells in the tumour microenvironment and the drivers of fibrosis. We have recently identified two pathways that mechanically reprogram PSCs and the tumour microenvironment to physiological conditions to inhibit fibrosis, cancer cell invasion, and modulate immune response. One of these mechanisms involves the G protein-coupled estrogen receptor (GPER). Modulating GPER mediated mechanosignalling has emerged as a powerful target in PDAC paving the way to implement new therapeutic approaches, which are so urgently needed. Building on our published data, we plan to demonstrate the efficacy of newly-synthesized compounds to target mechanotransduction of cancer and stromal cells as a therapeutic strategy in PDAC. Within the group of stromal cells, we will focus on: (i) PSCs to target fibrosis, and (ii) tumour associated macrophages, which are known to have tumour-promoting properties. Following this, we want to investigate the efficacy of self-assembling peptide hydrogels to deliver these compounds to pancreatic organoids. The first stage of each work package will be focused on the experimental verification of the efficacy of these compounds to target the different PDAC cell types and how these compounds can be more effec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Action for advanced drivers assistance and vehicular control system implementation, standardisation, optimum use of the road network and safety' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Research and development have created a range of advanced driver assistance systems (ADAS) that may facilitate the tasks of drivers in the growing complexity of traffic conditions. Appropriate ADAS will be selected from a problem focussed angle and analysed in a multidisciplinary approach, in order to gain new policy insights.All the stages for a potential breakthrough of ADAS will be investigated: the market conditions, the impacts on driving behaviour, road safety and environment, role of the public regulator, public acceptance, implementation strategies etc. Assessment methodologies will be developed and applied in order to deliver empirical evidence. This evidence together with questionnaire surveys will fit into a developed division scheme.This approach leads to an integrated framework suited for designing road safety policies to help realise suitable ADAS. Policy recommendations and guidelines are put forward in the last stage.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'HOLISTIC CAPABILITY AND TECHNOLOGY EVALUATION AND CO-CREATION FRAMEWORK FOR UPSKILLED FIRST RESPONDERS AND ENHANCED CBRN-E RESPONSE' in the context of a Horizon Europe call.

assistant: **Objectives**

Countries worldwide, amid threats and incidents targeting civilians, invest in reinforcing their CBRN-E related capabilities. In Europe and in most cases, the teams responding first are not trained specifically, nor equipped sufficiently to face the kind of hazards, to provide the assistance to victims and to follow the decontamination processes that a CBRN-E incident implies. At the same time, resources are limited, exercises and trainings are siloed per organization, lacking of proven procedures, and digital tools. TeamUP addresses these challenges establishing a unified framework of evaluating capabilities, procedures and co-developed solutions to be used in CBRN-E preparedness and response. The process results to an innovative Toolkit for Detection-Identification-Monitoring, coordinated operations and efficient and safe SaR supported by AR, digitally upgraded Triage and Breath Analysis, Fastly Deployable Mass Decontamination System and monitored people and infrastructure decontamination. Also, it offers Incident Management and digital Training Tool for FRs and citizens enhancing preparedness, and response. TeamUP, brings several actors together (training centers, FRs, experts and non-experts) identifying their specific needs, enforcing in parallel cross-sectoral, cross-border collaboration and facilitating knowledge sharing through a continues evaluation approach in a rich programme of Tabletop,  Small-Scale Exercises as well as Small Scale and Full-Scale Trials proving new knowledge on capabilities, technology performance and operating procedures. The solution will be finally validated in France and in Greece through the extensive participation of 8 end user-organizations, and a very competitive technical team, experienced in EU impactful funded projects, aspiring
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The first true minimally-invasive Spinal Fusion System' under Horizon Europe.

assistant: **Concept**

Over 1M spinal fusion procedures performed annually worldwide. Current spinal fusion procedures are highly invasive: they are based on building “screw-bridges”, connected by metal rods stabilizing motion between vertebrae. There are no effective treatments in the market that substitute the current invasive implants. zLOCK is a small implant that resolves spinal fusion by eliminating the need for screws and rods. zLOCK minimizes the invasiveness of procedures through a percutaneous approach, where only a small skin incision is required for implant placement, making it suitable for outpatient procedures. zLOCK can revolutionize spinal fusion standard clinical practice and the market. The implant value propositions have been confirmed in a first in human trial. With the EIC Accelerator project, ZygoFix will complete the necessary upgrades and clinical validation activities, achieve CE-mark and accelerate the time-to- market of zLOCK.


**Keywords:** Spinal fusion,3D printing,minimally invasive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Identification of novel targets to improve glioblastoma therapy' (INTIGT), addressing dissemination and exploitation.

assistant: **Impact**

Glioblastoma (GBM) is the most common malignant primary brain tumour in adults. The current standard of care is surgical resection of GBM tumours followed by chemotherapy and ionizing radiation (IR). Despite these intense efforts, GBM tumours remain incurable and the median survival rate of GBM patients remains only ~15 months. This dismal clinical outcome underscores the urgent need for novel therapeutic strategies for GBM. At the cellular level, GBM tumours contain a rare population of self-renewing, highly invasive stem cells termed brain tumour stem cells (BTSCs) that are endowed with properties to proliferate, spur the growth of new tumours, and at the same time, evade IR and chemotherapy. Thus eradicating BTSCs in tumour bulk represents a promising approach to fight brain cancer at its root. However, there are presently no treatments targeting BTSCs in GBM.Recent preliminary data obtained by the applicant at McGill University (Montreal, Canada) led to the hypothesis that a novel signalling pathway, galectin1/HOXA5, controls BTSC behaviour and represents a promising target to eradicate BTSCs. Thus, the applicant will join the Laboratoire de lAngiogense et du Microenvironnement des Cancers at University of Bordeaux to test this hypothesis, under the supervision of Pr. Bikfalvi. The host, the supervisor and the candidate represents the perfect match to realise this proposal and the project is designed to bring forth a two-transfer of knowledge between the host and the candidate. The advanced techniques and transferable skills that the candidate acquires through this research will largely broaden his competencies and increase his employability as an independent researcher in the field of neuro-oncology. Results generated through this proposal will be innovative and of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Interactive Storytelling for Creative People' (INSCAPE) targeting Sixth Framework.

assistant: **Abstract**

INSCAPE aims at enabling ordinary people to use and master the latest Information Society Technologies for interactively conceiving, authoring, publishing and experiencing interactive stories whatever their form, be it theatre, movie, cartoon, puppet show, video-games, interactive manuals, training simulators, etc.  INSCAPE will generate and develop the knowledge in the emerging domain of Interactive Storytelling by researching, implementing, demonstrating and disseminating a complete suite of innovative concepts, tools and working methods tightly integrated in a homogeneous web-based framework and offering a full chain to people with no particular computer skills, from content acquisition and creation, organising, processing, sharing, and using all the way to publishing, from creators to viewers".  INSCAPE will also address issues such as the acquisition, the creation, the management and the sharing of interactive stories or their real-time multi-sensorial rendering combined with natural agent behaviours and multimodal interfaces. It will also provide innovative natural interfaces and devices for intuitively creating or living interactive stories within multi-dimensional virtual, augmented and mixed realities. By addressing this domain, INSCAPE goes beyond "standard" content creation research and technology development projects and will address scientific and industrial simulation, training, education, poetry, art, emotions, cultural and human context and diversity.  The specification of the project will be driven by an analysis of the needs of real world users participating in the project as partners or involved in the INSCAPE Open Community. Through the lifetime of the project, the INSCAPE integrated system will be available in successive versions (alpha, beta, final
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'PATTERNING BY UV LASER MATERIAL REMOVAL' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of this project was to develop and construct a laser based machining centre, that combines the newest development in micro-machining, scanner technology and UV-laser technology. The association of UV-laser technology with a scanning system instead of a traditional linear axis positioning system can increase speed, precision, flexibility and accuracy of the laser material processing. A further application for such a hybrid system is in the field of laser based refractive eye surgery. Currently in the field of laser based refractive eye surgery, masks are being used to locally ablate or remove surface tissue from the Cornea. When dealing with unsymmetrical eyes irregular ablations have to be made for a successful operation. By using scanning devices, UV-lasers and improved ablation strategies, a more accurate local ablation can be achieved. This micro-surgery of the eye could lead to breakthroughs in refractive eye surgery. Being able to configure each operation to each individual eye, would dramatically improve results and subsequently the general acceptance of laser based eye operations.The LCD manufacturing process is one example where a hybrid system can be successfully implemented in a production line, leading to considerable cost reductions, higher product quality and therefore an increased competitiveness. LCD components are made up of multiple layers. For the electrical contacting of inner layers, the overcoating layer must be locally removed. Currently, this is done using large clichés (rolls) that stamp holes through the layers. They are individually manufactured and stored for each LCD component produced. The surface of each roll is structured differently with three-dimensional profiles that are used for stamping through the overcoating layer. By implem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Genomic observation and perturbation: genetic modifiers to untangle disease mechanisms of RFC1 repeat expansion' (GEMREX), addressing dissemination and exploitation.

assistant: **Impact**

Biallelic repeat expansion in RFC1, an essential gene involved in DNA replication and repair, are a leading cause of ataxia and neuropathy in the adult population. Nonetheless, the exact mechanism linking RFC1 repeat expansion and neurodegeneration remains elusive. The prevailing hypothesis is that the repeat may lead to a partial loss of function of RFC1, by affecting expression of neuron specific RFC1 isoforms or by impairing its fine regulation in terminally differentiated neurons, including sensory neurons and Purkinje cells.The objective of proposal is to leverage state-of the-art genomic medicine methods, including the observation of the naturally occurring genetic variation and controlled genome perturbation, to unravel disease relevant pathways.  We will perform a genome-wide association (GWA) analysis complemented by long read sequencing to identify genetic modifiers of onset, phenotype and progression of RFC1 disease. We will take advantage of the Crispri technology in genetically engineered iSensoryNeurons to further investigate the effect of GWA loci and to identify additional factors which can modulate RFC1 expression and ameliorate or exacerbate the molecular phenotype. As modifiers are likely to act at cell specific and dynamic level, genetic data will be paralleled by single-cell approaches in post mortem cerebellum and dorsal root ganglia, as well as IPSC sensory neurons and cerebellar organoids. Finally, given a high carrier frequency of RFC1 expansion nearing one out of ten people, we will try to understand whether the repeat itself can act as a modifier of common health and disease traits at population level. The results will hopefully lead to a better understanding of disease causing mechanisms and identify potentially druggable targets. The study o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Programmable Systems for Intelligence in Automobiles' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The ambition of PRYSTINE is to strengthen and to extend traditional core competencies of the European industry, research and universities in smart mobility and in particular the electronic component and systems and cyber-physical systems domains. PRYSTINE's target is to realize Fail-operational Urban Surround perceptION (FUSION) which is based on robust Radar and LiDAR sensor fusion and control functions in order to enable safe automated driving in urban and rural environments. Therefore, PRYSTINE's high-level goals are:1. Enhanced reliability and performance, reduced cost and power of FUSION components2. Dependable embedded control by co-integration of signal processing and AI approaches for FUSION3. Optimized E/E architecture enabling FUSION-based automated vehicles4. Fail-operational systems for urban and rural environments based on FUSIONPRYSTINE will deliver (a) fail-operational sensor-fusion framework on component level, (b) dependable embedded E/E architectures, and (c) safety compliant integration of Artificial Intelligence (AI) approaches for object recognition, scene understanding, and decision making within automotive applications. The resulting reference FUSION hardware/software architectures and reliable components for autonomous systems will be validated in in 22 industrial demonstrators, such as:1. Fail-operational autonomous driving platform2. An electrical and highly automated commercial truck equipped with new FUSION components (such as LiDAR, Radar, camera systems, safety controllers) for advanced perception3. Highly connected passenger car anticipating traffic situations4. Sensor fusion in human-machine interfaces for fail-operational control transition in highly automated vehiclesPRYSTINE’s well-balanced, value chain oriented consortium, is composed