RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'PREPARED “ENABLING CHANGE”' (PREPARED).

assistant: **Innovation**

IPCC climate change scenarios have a global perspective and need to be scaled down to the local level, where decision makers have to balance risks and investment costs. Very high investments might be a waste of money and too little investment could result in unacceptable risk for the local community. PREPARED is industry driven, 12 city utilities are involved in the project and the RDT carried out is based on the impacts of climate change the water supply and sanitation industry has identifed as a challenge for the years to come. The result of PREPARED will be an infrastructure for waste water, drinking water and storm water management that will not only be able better cope with new scenarios on climate change but that is also managed in a optimal way. We will have complexes monitoring and sensor systems, better integration and handling of complex data, better exploitation of existing infrastructures through improved real time control, new design concepts and guidelines for more flexible and more robust infrastructures. PREPARED will involve the local community in problem identification and in jointly finding acceptable system solutions, that are supported by all, through active learning processes. Activities and solutions in PREPARED will be based on a risk assessment and risk management approach for the whole urban water cycle, through the development of innovative Water Cycle Safety Plans. Other innovations are sensors and models that will enable faster and better actions on changes and new design rules for more resilient design. We will combine European knowledge with valuable knowledge from Australia and the USA, to make the European Water sector more competitive. This to enable our industrial partners to export the products developed in PREPARED to other regions o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multicellular regulation of insulin secretion from pancreatic islets' to be submitted under Horizon 2020.

assistant: **Abstract**

Type 2 diabetes mellitus, one of the major healthcare challenges of our time, is characterized by failure of beta cells to functionally adapt to increased peripheral insulin resistance. The resulting chronic elevations in blood glucose concentration are associated with heart, kidney, liver, nerve and retinal disease, as well as cancer. Here, by combining novel optogenetic, photopharmacological and innovative imaging approaches, we aim to unravel the complexity underlying the multicellular regulation of insulin secretion from islets of Langerhans during health and disease. In particular, we will examine a role for privileged pacemakers/hubs in orchestrating population responses to stimuli, identify what makes these specialized cells unique at the RNA/protein level, and understand how they contribute to islet development and failure. Furthermore, we will address whether the intraislet regulation of insulin secretion operates in vivo to determine glucose homeostasis, focusing on the neural-endocrine interface. Lastly, the mechanisms underlying islet cross-talk will be investigated directly in situ within the pancreas of living mice, paying close attention to the roles of the vasculature and secreted factors. As such, these studies should unveil a new route for restoration of insulin secretion in man, as well as provide the foundation for the de novo construction of islets for transplantation.


**Keywords:** type 2 diabetes, beta cell, islet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Identifying the steps required for meiotic DNA double-strand break formation' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

At the onset of prophase of the first meiotic division, meiotic cells undergo complex molecular events with the induction of several hundred DNA double-strand breaks. These DNA breaks are required because they initiate recombination between homologous chromosomes and to allow chromosome segregation during meiosis. They are essential for fertility. However, they represent a major challenge for genome integrity.It is thought that meiotic DNA break formation is under tight control to ensure that all breaks are properly repaired to maintain genome integrity. But how this control implemented is unknown. We postulate that three critical steps take place to ensure meiotic DNA break formation at the right time, right place, and right frequency. We will test this hypothesis by addressing in mice the three following questions:Q1: We will ask whether a homology-sensing process brings homologous chromosomes in spatial proximity before DNA break formation to improve DSB repair efficiency and avoid topological conflicts. If this is the case, we will determine the molecular mechanism.Q2: We will determine whether the genomic sites undergoing DNA breakage interact with structural components of chromosome axes before break formation, and how. This interaction is predicted to be necessary for proper DSB repair.Q3: We will determine how DNA cleavage is activated. We will do this through in vitro reconstitution of meiotic DSB formation.Answering these key questions will be possible by using in vivo and in vitro approaches. We will pioneer in vitro meiotic differentiation of mouse embryonic stem cells to overcome the current limitations for identifying novel components and interactions. We will thus decipher how a molecular machinery that has evolved from a DNA type II topoisomerase family
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'EU Title of project:  Solutions for the mushroom industry to emerging disease threats from Trichoderma and Virus' in the context of a Seventh Framework call.

assistant: **Objectives**

The mushroom industry SME AGs across Europe have come together to request the main research providers of applied mushroom research in Europe to conduct research on Trichoderma and Virus, two major problems for the industry.  Disease control has been compromised by the withdrawal of key pesticides and disinfectants by the EU in recent years, such as the withdrawal of approval for formaldehyde as a disinfectant and carbendazim fungicide for Trichoderma control.  The Mushroom SME AGs want to know what their members must do to prevent and / or control outbreaks of Trichoderma and Virus.  Disease control must now be based on a sustainable integrated pest management system (IPM).  IPM focuses on combining (i) improved hygiene procedures (ii) knowledge of how individual diseases and pests spread within and between crops (epidemiology), (iii) improved diagnostics and (iv) optimum use of available products to control and reduce the incidence of disease.This project aims to provide research-based solutions for the mushroom industry to deal with these two relatively new major diseases affecting production. Application of the solutions developed by this project to the European mushroom industry will reduce crop losses and increase efficiency and competitiveness.  During the project we will (1) generate technical research-based information on how Trichoderma and MVX grow, survive and spread in mushroom compost in order to identify the weak links in the chain and the steps needed to strengthen them; (2) screen and evaluate alternative disinfectant and biocontrol products for use in disease prevention and control programmes; (3) identify, characterise and quantify the presence of pathogens on mushroom farms and compost facilities across Europe over a period of up to 12 months, using t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Molecular bases of kinetochore-microtubule attachment and their implications for cell cycle control' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Equal partition of the genetic material to the daughter cells in mitosis requires the accurate anchorage of the mother cell s chromosomes to spindle microtubules. This process takes place at kinetochores, complex scaffolds containing ~100 different proteins. Conceptually, kinetochores can be viewed as performing four distinct but highly integrated functions: 1) they bind centromeric chromatin at a specialized protein-DNA interface; 2) they build a dynamic microtubule-binding interface that is tightly linked to the centromere-binding interface; 3) they correct erroneous microtubule attachments; 4) they synchronize the progression of the cell cycle oscillator with the progression of the microtubule-kinetochore attachment process. In mammals, all four functions are essential, and their abrogation has untenable consequences for normal cell life. Conversely, their partial impairment has been implicated in chromosome instability and in the development of cancer and an array of genetic diseases. Our goal is to be able to map the kinetochore functions schematized above to the as yet largely uncharacterized architecture of the kinetochore and to unravel the elements of feedback control that allow their integration. By using a combination of structural and functional methods, we have made several recent important contributions to the field of kinetochore biology. In this application, we propose to take our efforts to a new level of complexity that will allow us to gain an integrated view of how kinetochores bind microtubules, how they correct improper attachment, and how they coordinate microtubule attachment with cell cycle progression. Our approach rests on strong experience in biochemical reconstitution and structural analysis, and is complemented by the introduction of method
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of an innovative acidic shape-selective mineral catalyst added pelletised fuel from organic wastes', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The problem of converting organic waste and residual substances into a further subsequent and meaningful use is a problem of European dimension. Despite intensive efforts to reduce waste and residual sub-stances from households and industry, large quantities still remain which must be deposited. One of the most pressing waste management problems are allocated with the treatment of municipal solid waste (MSW), PVC waste, sewage sludge and light-shredder fractions from car recycling. The objective of this project is the development of an innovative acidic shape-selective mineral catalyst added palletised fuel from organic wastes and to develop a prototype process for binding harmful materials in the production of briquettes from waste products by adding inorganic compounds such as CaO, MgO, MgCO3, silicates or Al2O3 and some acidic mineral catalyst. The product will be a dry pellet with comparable combustion and gasification qualities to coal, so that it can be burned directly without any necessary adaptation of an incineration or boiler system and without the need of further waste gas treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Novel, orally available immune modulator MP1032 with anti-SARS-CoV-2 and anti-cytokine activity' under Horizon Europe.

assistant: **Concept**

The current global COVID-19 pandemic has caused severe health and socio-economic challenges. Despite significant improvements in the treatment of critical COVID-19 patients and advances in vaccine development, there is still an urgent need for safe and effective early-intervention treatments. To reduce disease burden, hospitalization time, and mortality, it is of critical importance to halt disease progression in early (mild-to-moderate) stages.  Our new drug, MP1032, has a dual mode of action, targeting two important mechanisms (immune system overactivation and viral replication) in the early development of COVID-19. Its unique mechanism of self-regulation prevents immune-suppression, which is critical for early intervention. In combination with the oral availability, favourable safety profile, rapid and affordable production scale-up, and potential to work against viral variants, MP1032 is the ideal candidate for early treatment of COVID-19, which can also be used safely in high-risk patients. Therefore, the iMPact project aims to clinically validate MP1032 in a Phase II trial for its ability to stop COVID-19 disease progression. The outcome of the project shall serve as a basis for follow-up rapid Phase IIb/III development and market registration.  Four international SMEs will work together in the iMPact project to achieve the objectives: 1) To demonstrate the efficacy of MP-1032 in hospitalized COVID-19 patients, 2) To demonstrate the effect of MP1032 on current SARS-CoV-2 variants, 3) To develop a GMP-compliant production scale-up process for MP1032, 4) To ensure that the clinical development plan is in line with regulatory requirements and 5) To collaborate with existing EU research networks. We have 29 clinical sites on board, and the required expertise for upsca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of sustainable electrochemical corrosion protection systems for reinforced concrete structures' (DOSECOPS).

assistant: **Innovation**

Corrosion of reinforcing steel in concrete structures is a worldwide problem and affects a large number of infrastructures. Two major causes connected to corrosion of reinforcing steel are the carbonation and chloride attack. Concrete carbonation produces a carbonated surface layer in which the pore solution pH value is depressed to near-neutral levels. A fall in pH to values below 10 at the steel can render the steel passive film thermodynamically unstable and thus cause steel corrosion. While chloride attack causes localised breakdown of the passive film that initially forms on steel as a result of the alkaline nature of the pore solution in concrete. The harmful chloride ions can be originated from the use of contaminated mix constituents or from the surrounding environment such as deicing salts or seawater. The corrosion of steel not only reduces the strength of reinforcement but also can lead to cracking and spalling of cover concrete because of the substantial volume increase that accompanies the transformation of iron to rust. To promote the effective application of reinforced concrete it is important to protect the reinforcing steel from corrosion during its service life. This proposal is to explore a new electrochemical remediation of reinforced concrete structures by combining conventional electrochemical processes, such as the electrochemical chloride removal for chloride contaminated concrete and the electrochemical realkalisation for carbonated concrete, with electrochemical nanoparticle injection. Using the new electrochemical processes, not only can they remove chlorides from concrete and increase alkalinity in concrete pore solution but also simultaneously inject nanoparticles into the concrete to enhance its mechanical properties as well as improve its
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of oral probiotic-based vaccines for sustainable disease control in aquaculture' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Aquaculture is vital to global food security, but the industry is increasingly threatened by bacterial pathogens that cause significant economic losses. Among these, Photobacterium damselae subsp. piscicida is a major pathogen in the Mediterranean area, causing high mortality rates in valuable fish species like the gilthead seabream and Senegalese sole. Traditional vaccination methods in aquaculture often face challenges, including poor efficacy and the stress caused to fish during handling. Thus, there is a critical need for innovative and effective vaccine strategies that are easy to administer and provide robust protection.This proposal (PhotoVaccine) aims to address this challenge by developing novel oral vaccines using spores of probiotic Bacillus strains to deliver Phdp antigens. Building on the NUTRIMU groups recent proof-of-concept for spore surface display technology, this proposal aims to: i) engineer Bacillus spores to display Phdp antigens on their surface, and ii) assess the immunomodulatory effects and protective efficacy of these PhotoVaccines in fish models. Specifically, we will address the following questions:- Can spores of B. subtilis be used as oral delivery vehicles for Ph. damselae subsp. piscicida antigens?- Are oral PhotoVaccines effective in protecting fish against infections?- What type of response is elicited by oral PhotoVaccines on fish intestinal mucosa?By the end of this project, we aim to develop at least one PhotoVaccine candidate with potential for commercial use, contributing significantly to disease management in aquaculture. This research will also enhance our understanding of fish immunology, particularly how mucosal vaccines can overcome intestinal tolerance to provide long-term protection. The outcomes of this project could trans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DEEP PURPLE: darkening of the Greenland Ice Sheet' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The stability of the Greenland Ice Sheet (GrIS) is a threat to coastal communities worldwide. The PIs have changed our understanding of why it darkens during the melt season, becoming increasingly deep purple due to pigmented ice algal blooms in the ice surface, producing more melt and accelerating the GrIS towards its tipping point, and increasing sea level. The next step jump in our understanding of biological darkening will be provided by DEEP PURPLE, which will establish the factors that control ice algal blooms. These factors are essential for modelling of future melting, which require a process-based understanding of blooming. DEEP PURPLE will quantify the synergies between the biology, chemistry and physics of ice algae micro-niches in rotting, melting ice, and examine the combination of factors which stabilise them. State-of-the-science analytical and observational methods will be employed to characterise the complex mosaic of wet ice habitats, dependent on factors such as the hydrology, nutrient status, particulate content and light fields within these continually evolving ice-water-particulate-microbe systems. We will quantitatively assess why and how the fine light mineral dust particulates contained within the melting ice amplify the growth of ice algae. The particulate content and composition of different layers in the GrIS is dependent on age, and so the algae that the melting ice can support may fundamentally change over time. We look back to understand if the ice biome has changed through the Anthropocene via analyse of fjord sediments. The first draft genome of ice algae will show their key adaptations to glacier surface habitats. DEEP PURPLE looks forward by providing the critical field data sets and conceptual models of ice algal growth that will faci