RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development and demonstration of materials and manufacturing process for ultra high reliability electric Anti-ice/De-ice thermal layers for high strain rotor blades and helicopter airframe sections' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The expected outcome of the NO-ICE-ROTOR project is structural and environmental test substantiation of ultra high reliability heater layers which are capable to be integrated into an advanced tilt civil rotorcraft configuration with high cruise speed, low fuel consumption and gas emission, low community noise impact, and high productivity for operators.The realisation of such an advanced tilt civil rotorcraft is the objective of the Clean sky Fast Rotorcraft Project (FRC). It is the aim of this project to use technologies developed through the Clean Sky Programme to demonstrate a compound rotorcraft configuration that combines the vertical lift capability of the conventional helicopter with the speed capability of a fixed wing aircraft in a sustainable way.The overall objectives of the NO-ICE-ROTOR project are:  -Design and development of heater layer for application in tilt rotors-Establishment of test criteria and test matrix project -Manufacturing of suitable test pieces for ice protection system (IPS) testing-Structural and environmental rig test adaptations for IPS testing-IPS rig and coupon test realization and tests results -Synthesis of results: comparison of performance of materials and of technologies tested The specific objective of the NO-ICE-ROTOR project is to develop heater layers to be embedded in composite structures to provide anti-icing and de-icing capability where safety requirements dictate ultra high reliability, while operating in high strain and vibration conditions. Structural and environmental testing will be conducted on representative test items consisting of functional heater layers embedded in the prop-rotor blade and airframe sections of a tilt-rotor configuration intended for civil certification.


**Keywords:** Tilt- rotor, rotor blade
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Escherichia coli pathogenic for poultry: molecular approaches for improved diagnostic and control' in the context of a Fourth Framework call.

assistant: **Objectives**

Among bacterial infections , collbacillosis is the first cause of morbidity and mortality in poultry breeding, where it provokes different types of syndromes, mainly respiratory tract infections and reproductive disorders. Two unsolved problems actually impair a satisfactory control of avian colibacillosis in Europe: - no reliable methods can be presently used in veterinary diagnostic laboratories, which would be necessary to identify, the causative strains of Escherichia coli. - no fully effective vaccination is presently available for avian colibacillosis, probably due to the large variety of E.coli strains which are able to provoke colibacillosis infection in poultry. Moreover, although several data and observations argue in favor of close genetic relationships between some pathogenic E.coli isolates of human and avian origin, especially those invoved in extra-intestinal septicaemic diseases, this particular point has never been well-documented in Europe. Finally, the intensive use of antibiotics in animal husbandry leads to the selection of antibiotic resistances, which may be transferred to Gram-negative bacteria pathogenic for man. Thus, this study includes two main objectives: - to improve poultrv breeding by a better control of avian colibacillosis, which could be obtained from a better knowledge of the responsible E. Coli strains. Human health, through a detailed study of genetic homologies between avian and human pathogenic E. Coli isolates, and a survey of antibiotic resistance. For this purpose, the work will be organized into three complementary parts:  -In part 1, the specific characteristics of avian pathogenic E.coli (APEC) will be investigated on a large sample of avian E. Coli strains collected in three European countries (FR, ES, and BE). This charact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Hybrid imaging agents for the illumination of peripheral nerve structures' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The aim of the ILLUMINATING NERVES project is to develop and synthesize new imaging agents that eventually can be used for surgical guidance around delicate nerve structures. The applicants research group already has made a major contribution to the clinical field of surgical guidance by introducing a concept wherein a multimodal/hybrid, imaging agent is used to provide fully integrated preoperative 3D imaging, surgical procedure planning, and real-time surgical fluorescence guidance. Illumination of delicate anatomical structures like nerves will have a direct influence on the quality of life of patients and as such creates a new window of opportunities for surgical guidance and for the chemical development of hybrid imaging agents. To illuminate both somatic and autonomic peripheral nerves, imaging agents will be developed that bind to receptors on myelinating Schwann cells and/or accumulate in neurons. These different targeting concepts dictate the use of different scaffold molecules varying from targeted antibodies to modified neurotoxin proteins that act as bionanoparticles and viral capsids, each scaffold demanding different synthetic routes for functionalization. For this particular application, the visualization of small nerves, especially the fluorescent imaging contrast has to increase compared to conventional imaging agents. The applicant’s multidisciplinary track record the chemical and (bio)medical field, combined with his proven ability to bridge the gap between bench and bedside aids in the successful integration of synthetic chemical strategies with biomedical assays and in vitro/in vivo validation studies. Although possibly providing interesting imaging agent candidates suitable for optimization towards a future clinical translation, the project will ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Towards a dynamic institutional theory of entrepreneurship: How national institutions shape the triggers, timing, and types of entrepreneurial processes in innovation-intensive industries' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

It is a stylized fact that prospective entrepreneurs differ in how they proceed to found new firms. Interestingly, though, the literature on process-oriented entrepreneurship does not provide a theory on how national institutions influence the behaviour of prospective entrepreneurs. The proposed project seeks to close this gap. The analytical framework is derived from the literature on national institutions, including theories on the ‘market based view’, ‘national innovation systems’ and ‘varieties of capitalism’. These strands illustrate how institutional differences shape business practices of established firms. Extending these insights to prospective entrepreneurs, the project explores three hypotheses. 1) Rigid labour-market institutions increase the likelihood that potential entrepreneurs start new businesses out of necessity. 2) National institutions influence the order and timing in which business factors are acquired. 3) Institutional differences determine the ‘windows of opportunity’ during which prospective entrepreneurs need to have acquired necessary business factors, as they will otherwise give up their endeavour. To test these hypotheses, German and US inventors are interviewed who hold highly cited patents with commercial applicability in high-tech industries. The interviews will be analysed with ‘optimal matching techniques’ to reveal how national institutions shape the triggers, order, timing, and ‘windows of opportunities’ of firm foundation processes. The insights gained are of highest relevance to economic policy-makers, management scholars and political scientists alike. The combined research stays at Columbia University (New York, USA) and Utrecht University (Netherlands) offer a unique opportunity to complete the project by allowing me to gain new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Spin related phenomena in mesoscopic transport' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The rapid progress of nanotechnology made possible the realization of nano-devices in which the motion of the carriers obeys the laws of quantum mechanics. They offer a unique laboratory for study of fundamental quantum effects, such as entanglement, topological phase and new states of matter arising from many- body correlations. Besides, mesoscopic objects can serve as components of the electronic and optoelectronic devices of new generation. In this perspective the study spin related phenomena is of particular importance as use of the spin degree of freedom opens a way to practical realization of such nanodevices as single electron memory elements, spin transistors, quantum beam splitters and spin filters. Another important topic in the field of mesoscopic transport is connected with many- body correlations, which manifest itself via variety of intriguing physical phenomena. In many of them spin plays a major role. The analysis of an interplay between spin dynamics and mesoscopic many- body correlations is thus an actual task. In a current Multidisciplinary Marie Curie FP7-PEOPLE-IRSES project SPINMET we plan to analyse many body spin related phenomena in various types of mesoscopic structures focusing on following main topics: i) Spin- interference phenomena in non-single connected mesoscopic objects ii) “0.7 anomaly” and related phenomena in 1D ballistic transport iii) New states of quantum spinor 1D liquids. iv) Spin currents and spin accumulation in real mesoscopic structures. The final objective to understand the mechanisms governing mesoscopic spin dynamics and its interplay with many-body correlations and formulation of practical recommendations for their applications in High-Tech industry: silicon spin transistor without ferromagnetic contacts; resistance stan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Education as a Lifelong Process – Comparing Educational Trajectories in Modern Societies' (EDULIFE), addressing dissemination and exploitation.

assistant: **Impact**

Over the last decades, modern societies have evolved into knowledge-based economies in which the role of education and the organisation of educational institutions have become important in all phases of the life course. More than in the past, today, education is a lifelong process where the individual acquires skills and competences in formal and non-formal learning settings throughout the entire life-span. Most empirical research on education is still based on cross-sectional studies and does not analyse education as a highly time-dependent, stepwise, and cumulative process. The aim of the project is therefore to study how individuals’ educational careers and competence trajectories unfold over the life course in relation to family background, educational institutions, workplaces, and private life events. The project takes an explicit life course perspective and utilises innovative data from the new German National Educational Panel Study (NEPS). The NEPS data will be compared with longitudinal data from five carefully selected additional countries. Based on its cross-national comparisons the project will do both, (a) establish the generality of findings and (b) study the specific impact of variations in educational institutional settings across countries.In substantive terms, the project is structured along four themes: (1) the quality of pre-school education and its short- and longer-term effects on individuals from disadvantaged backgrounds; (2) consequences of different models of differentiation in secondary school and their consequences on competence development and educational opportunities; (3) different vocational training trajectories and their impact on entry into the labour market; and (4) the interaction of lifelong learning and job careers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Molecular pathology of anti-viral T cell responses in the central nervous system' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Immune responses against viruses in the central nervous system (CNS) can result in devastating outcomes. Even non-cytolytic CD8+ T cell interactions, which purge viruses from neurons without triggering cell death, can induce permanent damage. Yet, how this immune response irreversibly disrupts neuronal homeostasis remains unclear.Here, we will elucidate the molecular mechanisms that underlie non-cytolytic CD8+ T cell engagement with infected neurons and their consequences on neuron function in vivo. We hypothesize that inflammatory signalling in neurons, induced by non-cytolytic CD8+ T cell interactions, triggers metabolic and epigenetic changes that underpin permanent neuronal dysfunction.""PATHOCODE"" will test this hypothesis by harnessing a unique animal model of T cell-driven virus encephalitis in the following objectives: 1. Discern neuronal subset-specific vulnerabilities and antigen-dependent versus bystander effects in the inflamed CNS. We will perform single nucleus RNA sequencing to examine whether T cell engagement (a) differentially affects molecularly distinct neurons, and (b) affects non-targeted, uninfected neurons. 2. Uncover the consequences of non-cytolytic T cell engagement on neuronal metabolism. We will use cell-specific mitochondrial reporter mice to investigate immune-driven metabolic adaptation of neurons in vivo. 3. Determine how non-cytolytic T cell engagement affects the neuronal epigenome. We will employ cell-specific nucleus/ribosome reporter mice to elucidate how T cell engagement affects the translatome and epigenome of infected cells. 4. Rescue T cell-mediated neuronal dysfunction by restoring metabolic pathways. We will exploit recent CRISPR/Cas9 technological advances to restore neuronal gene expression and uncover the relevance of imm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Platform to efficiently stream anything (focusing on games, SME and B2B applications), anywhere (to any mobile device)'.

assistant: **Concept**

RemoteMyApp is the platform to deliver streaming services to three vital mobile devices market segments: (i) gaming, (ii) business applications to support remote servicing and remote office collaboration (especially for SMEs) and (iii) B2B applications. For each of these segments, RemoteMyApp offers corresponding module. RemotR (i) for games streaming is the one already introduced on the market to demonstrate our innovative streaming technology in the most demanding environment. As the next step, RemotS (ii) module will be introduced, to reach the market of business applications for SMEs. This module will add features of streaming from the cloud (removing the need for physical PC, reducing costs and maintenance tasks) and pay-as-you-go charging. Finally, RemoteB2B (iii) module will be added with simple application-builder environment, where everyone can build (with no programming skills), share and monetize own mobile RemoteMyApp applications. This module will secure the future of whole ecosystem, by giving into the hands of users tools to shape any applications they may need.With our innovative streaming technology (improved transmission delays, better responsiveness to different screen sizes and advanced controls and inputs configuration) ultimately, we want to convert mobile devices into modern entertainment (gaming) and work (business) stations.RemoteMyApp technology was developed by Red Sky company – legendary Polish web services developer (our most popular product has reached 80th place on the ranking of 100 most visited sites worldwide – the highest position taken by any Polish website). For technology commercialization a spin-off company was established in Poland/Israel, under the RemoteMyApp name.The objectives of Phase 1 of this project are: technological feas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'From Local Elements to Globally Ordered TOPological states of matter' (LEGOTOP).

assistant: **Innovation**

We present a novel constructive approach for realizations of topological states of matter. Our approach starts with well-understood building blocks, and proceeds towards coupling them to create the desired states. This approach promises both a guide for a tunable experimental realization of states which have not been observed so far, and a theoretical tool for deeper understanding of different topological states, their dualities and inter-relations.We will apply the constructive approach in two different directions. In the first direction our goal will be the construction of topological superconductors. Our tool will be Josephson junctions in which superconductors are coupled by two- and three-dimensional electronic non-superconducting systems. Two dimensional examples include transition metal dichalcogenides, Quantum Hall states, Quantum Anomalous Hall states, and the (111) bi-layer state, which may be viewed as a fractionalized electron-hole condensate. Three dimensional examples include Weyl semi-metals and weak topological insulators.In the second direction our goal is the construction of fractionalized spin liquid states. Our building block will be a Majorana-Cooper box, which is a superconducting quantum dot coupled to semi-conducting wires that host Majorana zero modes. We will consider arrays of such boxes. The ratio of the box's charging energy to inter-box tunnel-coupling determines whether the array is superconducting or insulating. We will aim to use insulating arrays for realizing fractionalized and non-abelian spin liquids, study the transition to the superconducting state, and search for possible relations between the topological properties on both sides of the transition.A deeper comprehension and a feasible path for realization of these states would hav
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pathogenesis and treatment of splicing factor mutant myelodysplastic syndromes' (PATRES-MDS).

assistant: **Concept**

The myelodysplastic syndromes (MDS) are a heterogeneous group of malignancies of the haematopoietic stem cell (HSC) with a tendency for leukaemic transformation. Despite some new therapies, the MDS are lethal to most sufferers and in need of new effective treatments. Splicing factor gene mutations are the commonest class of somatic alterations in MDS and primarily affect the genes SF3B1, SRSF2, U2AF1 and ZRSR2. The mutations are associated with altered mRNA splicing, but each affects different transcripts and it is unclear how they drive MDS. It has been hypothesised that different mutations share pathogenetic mechanisms, distinct from their effects on alternative splicing. Recently, augmented R-Loop formation leading to cell cycle arrest of haematopoietic progenitors was identified as one such mechanism. However, we have no understanding of how the mutations drive clonal HSC expansion, a critical node for the development of new treatments. To this end, we and others described the phenomenon of clonal haematopoiesis (CH), widely held as the precursor of MDS and other myeloid cancers. We observed CH driven by splicing gene mutations only in individuals aged ≥ 70-years-old. This and other observations point to an interaction between ageing and the ability of splice factor mutations to drive clonal expansion. Here, I propose to investigate the two most common variants in MDS, SF3B1-K700E and SRSF2-P95H. Research Plan1.Characterise the global impact of the mutations using state-of-the-art transcriptomics and proteomics 2.Use bone marrow samples from elderly humans to study the interaction of ageing with splicing factor mutations3.Generate mosaic mutant mice to investigate the impact of ageing and other perturbations on SF3B1-K700E and SRSF2-P95H haematopoiesisFindings will