RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ultra-broadband infrared gas sensor for pollution detection' (TRIAGE).

assistant: **Concept**

Air pollution is one of the largest risk factors for premature death, yet current portable monitoring technology cannot provide adequate protection at a local community level. • TRIAGE will develop a smart, compact and cost-effective air quality sensor network for the     hyperspectral detection of all relevant atmospheric pollution gases • Resolution and selectivity are two orders of magnitude better than current solutions for lower cost • Cloud-based, deep-learning algorithms enable automated short-term alerts and long-term trend analysis • Community-based testing is agreed with Swedish and Swiss environmental agencies and transport companiesThe sensor is based on an innovative, mid-IR supercontinuum laser providing ultra-bright emission from 2-10 µm in the infrared “fingerprint region.” The latest spectroscopic technology, including novel multi-pass cell and detectors, enables real-time detection of all major harmful gaseous components of air pollution with high sensitivity and selectivity, at levels far below the Immediate Danger to Life and Health (IDLH) concentrations. Precision multi-gas detection allows studies of synergistic effects from combinations of gases for the first time. In-built chemometric analysis and cloud connection will feed deep-learning algorithms and data storage to enable analysis ranging from long-term trends in air pollution to urgent local alerts.This smart photonic approach enables pervasive community-based sensing, allowing inventories of emitted pollutants and identification of pollution hotspots. Agreements with local authorities in Stockholm and Neuchâtel for distributed pollution monitoring from municipal buildings and with local bus companies in Sweden and Switzerland for mobile validation are in place.A comprehensive advisory board,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Defining the mechanism of the dual spindle assembly and alignment in the mammalian zygote', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The first embryonic division after fertilization is essential for development of the organism and has to promote the union of the parental genomes. My host lab recently showed that in mammalian zygotes two bipolar spindles form, which first independently congress the maternal and paternal chromosomes and then must be aligned in parallel for a faithful division. The novel dual spindle assembly provided a likely rationale for erroneous divisions into more than two blastomeric nuclei observed in human fertility treatment. Indeed, preventing the alignment of the two spindles gives rise to multi-nucleated two-cell embryos also in mice. Due to its recent discovery and the difficulty of imaging in the light sensitive zygote, dual spindle assembly and function remains elusive. It is for example unclear what the contribution of cytoplasmic versus chromosomal microtubule (MT) nucleation is for forming two spindles and why spindle alignment is error-prone and variable between different mammals. Recent advances in microscopy in my host lab now enable me to address these questions. In my project, I will dissect the mechanism of dual spindle assembly and function by combining light sheet microscopy, computational image analysis, and molecular perturbation. To achieve this, I will perform 4D imaging of live mouse zygotes at high resolution that allows me to track individual nucleation sites as well as MT tips. This will allow me to generate the first spatial map of MT nucleation and assess what the contribution of the two MT populations for dual spindle assembly is. Moreover, I will test which MT nucleation pathway is essential for dual spindle assembly by molecular perturbations. Finally, I will check if errors in spindle alignment are the cause of parental genome loss, by identifyin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New era in dark matter phenomenology, the dawn of the nuclear clocks' (DM-Dawn).

assistant: **Concept**

What is the  nature of dark matter (DM)? This central question in physics could be soon addressed thanks to the unprecedented sensitivity of nuclear clocks. These Th-229-base clocks are set to overcome the inherent limitations of atomic and molecular clocks, which are less sensitive to the nuclear parameters, which dominate almost all motivated models of ultralight DM (ULDM) . Laser excitation of Th-229 has just reached 1:10^11 sensitivity. Given that a precision of 1:10^8 suffices to probe DM-models with world record reach (even before nuclear clocks are actually constructed), it implies that the era of nuclear clock supremacy has begun! We propose three thrusts that harness this revolutionary advancement to search for ULDM. The first is driven by our joint theory-experiment demonstration that the line shape analysis of the Th-229 isomeric state excitation may potentially lead to 1:10^21 effective sensitivity to ULDM, due to the direct-enhanced dependence on the strong interaction parameters. The second is theoretical and experimental exploration of the enhancement factor of O(10^5), that is currently uncertain, and cannot be robustly established. The third focus on studying the formal implications of the era of nuclear-clock supremacy. We provide projection for the reach of nuclear clocks for axion and scalar ULDM.We also demonstrate that a nuclear clock can be used as a QCDometer sensing spatially-dependent couplings, due to artificial source, or from super-Planckian-based physics via couplings to moduli-remnants. We further introduce a new class of non-axion ULDM models, that address the strong CP problem, where the Cabibbo–Kobayashi–Maskawa elements vary in time, in addition to the nuclear parameters. It could be tested, thus, at accelerators as well as clocks, whi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Optical Coherence Tomography for Intraocular Lenses' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The replacement of the crystalline lens of the eye by an artificial intraocular lens (IOL) is one of the most frequent procedures worldwide (3 millions/year in Western Europe). The surgery is required to correct for the age-related loss in transparency (cataract), but it is also performed to correct for refractive errors, and may be envisioned to correct for presbyopia in a younger population (>45) with future accommodating IOLs that restore the eye focusing capability. Despite the development of new IOL designs and a steady market growth of IOLs (particularly of Premium IOLs, aiming at delivering optimal vision quality to the patient), the techniques to select the optimal IOL design have not evolved at a similar pace. As cataract surgery moves into new paradigms, access to ocular imaging-based technologies that allow accurate selection of the IOL and evaluation of the surgical outcomes becomes essential. The PRESBYOPIA ERC-Advanced Grant investigates basic mechanisms of the crystalline lens accommodation, to propose nature-inspired IOL designs to correct presbyopia. With this aim, we have developed a laboratory prototype for full 3-D quantitative anterior segment Optical Coherence Tomography (OCT) based on our proprietary method to reduce distortion and automatic quantification. We have demonstrated the capabilities of this instrument to provide accurate crystalline lens topography in vivo and full 3-D optical biometry in cataract patients pre- and post- implantation of IOLs. The OCT4IOL ERC-Proof of Concept will evaluate the marketability of this OCT line, generate new IP, developing a product commercialization plan, and reaching a strategic partnership alliance, with the ultimate goal of developing an instrument that brings eye surgery into new paradigms for IOL sele
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Neuropeptidergic modulation of synaptic circuits in fear and anxiety'.

assistant: **Objectives**

Fear and anxiety are Fear and anxiety are essential for survival. Adequate reactions to anticipated and perceived threats strongly depend on the current state, context and previous experience. What are the neurobiological mechanisms that underlie these adaptive behaviors? While synaptic circuits are the backbone to process threat signals and transform them into behavioral responses, increasing evidence suggests that neuropeptides tune these synaptic circuits in a state- and context-dependent manner, thus allowing for temporal control of excitability and plasticity. Neuropeptide receptors are abundantly expressed in neuronal circuits that regulate fear and anxiety. In fact, recent evidence suggests that most neurons synthesize multiple neuropeptides and, in turn, are regulated by multiple neuropeptide receptors that are expressed in highly cell type-specific patterns. Indeed, genetic alterations in humans as well as pharmacological and genetic experiments in mice indicate important roles for multiple neuropeptides in regulating fear and anxiety and, if dysfunctional, increasing the risk for multiple neuropsychiatric disorders. However, due to the lack of specificity of existing tools, the circuit mechanisms underlying these effects are largely unknown. In this proposal I aim to reveal cell type-specific neuropeptidergic signaling mechanisms for context-dependent regulation of cortical circuit activity, cellular excitability and synaptic plasticity. I will use cutting-edge in vivo imaging and circuit manipulation tools combined with region- and cell type-specific CRISPR/Cas9-mediated genetic ablation to reveal how these neuropeptidergic signaling mechanisms regulate behavioral responses in the context of fear and anxiety. This multidisciplinary approach will allow me to g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'THE NAMES OF GOD AND OF CHRIST IN THE SYNCRETIC RENAISSANCE:  MYSTICAL, MAGICAL AND VISUAL WORDS IN CHRISTIAN KABBALAH.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The present research project aims at examining fresh material about the syncretistic tradition in the 15th and 16th centuries: it includes a wide range of theories by the so-called Christian Kabbalists about the different names of God and of Jesus in the context of Renaissance thought. The study will focus especially on the Christian Kabbalistic reading of the Tetragrammaton, the Pentagrammaton, and the Trigrammaton, i.e. the various names of God as expressions of new Christological interpretations to Jewish Kabbalistic doctrines. More specifically, this project intends to devote greater attention to the analysis of Renaissance syncretism in two ways: as a linguistic instrument and as a performative power. The analysis will be examined through the writings of Giovanni Pico della Mirandola, Johannes Reuchlin, Giles of Viterbo, Niccolò Camerario, Francesco Zorzi and Arcangelo da Borgonovo. This research will also consider some unknown Jewish sources that influenced, either explicitly or implicitly, the Christian Kabbalistic theory of the divine names. Our purpose is therefore to answer the question of facing theological “otherness” in the Renaissance through a new type of cultural synthesis. In some way, combining Abrahamic faith with Kabbalah, Hermeticism and Trinitarian creeds, results in overcoming the conflicts of dogmas in order to converge towards a unified plurality of traditions. Starting with the hypothesis of a Kabbalistic “metamorphosis” of humanistic theology in the Renaissance, we hope that the proposed research will demonstrate that the Christian theories on Jewish divine names, against the background of Kabbalah and “barbarous wisdom”, was impossible without transgressing sacred boundaries and creating new values. Accordingly the work of many Christian Kabb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'The international analysis of postoperve cognitive dysfunction'.

assistant: **Innovation**

Objectives: Postoperative cognitive dysfunction (POCD) is common in elderly patients and significantly impairs their quality of life due to loss of memory and concentration. The decrease in mental performance and potential progression to overt dementia may have enormous socio-economic consequences. The aims of this project are to clarify these issues in 11 tasks involving a wide range of scientists from the fields of cognitive function, anaesthesia, pharmacology, cell biology, statistics, psychology, imaging and technical engineering.Postoperative cognitive dysfunction (POCD) is common in elderly patients and significantly impairs their quality of life due to loss of memory and concentration. The decrease in mental performance and potential progression to overt dementia may have enormous socio-economic consequences. The former contradictory and inconclusive studies within this field prompted a multicentre study in 1800 patients and controls, ISPOCD 1, that was made possible by support from the BIOMED1 program. ISPOCD 1 showed that POCD occurs in 24% of elderly patients one-week postopera tively and in 10% after 3 months. Further derivatives were a European psychometric test battery, rigorous diagnostic criteria, and several flexible software programs for data acquisition, processing, and analysis. We do not know whether the condition represents permanent brain damage and the consequences, aetiology, and patophysiology are unknown. The aims of the proposed study (ISPOCD 2) are to clarify these issues in 11tasks involving a wide range of scientists from the fields of cognitive function, anaesthesia, pharmacology, cell biology, statistics, psychology, imaging and technical engineering. This concerted action comprises both tasks to be performed by all participating centres
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Network Information Theory for NonLinear optical channels' (NIT-NL).

assistant: **Concept**

Optical fiber systems carry nearly all of the global Internet traffic and are critical infrastructure for modernsociety. Long-haul optical networks are often based on the notion of wavelength division multiplexing (WDM). Athigh signal intensities, WDM systems are impaired by the inherent nonlinear effects involved in fiberpropagation. In the literature, the fundamental limits of WDM transmission are investigated using informationtheory. The prevalent viewpoint only focuses on achievable rates for individual users under different behavioralassumptions for the interfering users. NIT-NL deviates significantly from this single-user viewpoint and proposesa multi-user information theoretic approach for the WDM channel that investigates the region of simultaneouslyachievable rates for all the different users. NIT-NL aims to exploit this holistic perspective and realize a moreefficient utilization of the optical network resources. This will be achieved via a) characterization of closed forminner and outer bounds to the capacity region based on realistic channel models, b) asymptotic analyses in thelimit of high transmit power to infer the nature of optimal strategies in the highly nonlinear regime, and c)derivation of optimality conditions for simple and practical schemes such as treating interference as noise toachieve the sum-capacity of the given model. NIT-NL will have a direct impact on the scientific communityengaged in the long-standing quest of dealing with nonlinear impairments in optical channels, and the multi-userinformation theory community that will welcome its enrichment on nonlinear channel models. It will also benefitthe European telecommunications industry and standardization initiatives.


**Keywords:** Information theory, interference channel, perturbative m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'System for Hydrology using Land Observation for Model Calibration' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The primary objective of this project is to construct and test a software package, SHYLOC, that allows users to combine a satellite image with digitised stream positions in order to determine the amount of surface water stored in a network of natural or man made (drainage or irrigation) channels over a certain area, at a certain time. The package will, in principle, be usable for calibrating hydrological models for a wide range of applications but it will be targetted especially at wetland areas that are protected by national, European and international environmental legislation, The European legislation that is of primary interest is the Habitats Directive (92/43) and the target international teaty is the 1971 Ramsar Convention on the Conservation of Wetlands of International Importance Especially as Waterfowl Habitat. The accuracy of the package will be tested on four wetland sites of scientific importance - the North Kent marshes and the Pevensey Levels in the UK - and Lakes Karla and Mavrouda in Greece. SHYLOC will be compared to water level measurements made during the project and water balance calculations made for the preceding years. The total number of checks for each site will be eleven. In order to ensure that the project meets the needs of end-users? a.n end-user board has been set up wllo will attend the meetings, comment on the quality and relevance of the work and guide future developments. The end-users are drawn from those who decide on the ernvironmental impact of water resource changes in areas of ecological interest.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Christian Illustrious Men: Christian Culture and Identity from Eusebius of Caesarea to Isidore of Sevilla' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This project aims to provide a multi-focal, trans-historical and trans-local analysis of the late antique Christian De viris illustribus (=DVI). It will demonstrate, against past analyses which have considered them as inert, timeless literary traditions, that the DVIs are deeply anchored into specific social, religious and historical contexts that they actively contributed to shape. ChrisVirIll will therefore shed new light on the impact of late antique literature on Christian identity and society. While the reception of these DVIs has been studied in quite some detail due to their success from the Middle-Ages on, their original purpose, context and meaning have received little attention. Yet, their success and impact on later periods cannot be fully grasped without a more comprehensive understanding of their initial production. This innovative project aims to fill this gap by offering answers on why and how, from the Constantinian turn, Christian authors appropriated the genre of the DVI, and how, from the time of Theodosius, through multiple continuations, they were developed to eventually reach ""canonization"" in later centuries. It will specifically focus on how this literary form was exploited to dynamically respond to new societal challenges and how they impacted the Christians' cultural identity. Providing a comprehensive, comparative and interdisciplinary analysis of these writings, this project will combine traditional philological-historical close-reading with insights from social and cultural studies (including gender studies). I believe that, thanks to this fellowship, my expertise in the history and literature of this period will help me reach my ambition of re-embarking on an academic career.""