RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'An iono-electronic neuromorphic interface for communication with living systems' (IONOS).

assistant: **Innovation**

While our understanding of the brain have made huge progresses, we are still inefficient in interfacing biological systems with electronics, both in terms of energy and integration potential. Pushed by the need to use conventional computers for building complex systems dedicated to brain interface applications, we have mostly capitalized on technologies and architectures inherits from microelectronic that are intrinsically not adapted to interface living systems. The IONOS project will shift the brain interface paradigm by developing new technologies designed to interact intimately with biological cells and capitalizing heavily on bio-inspiration. To reach this goal, the IONOS project will explore how to sense, stimulate and compute biological signals from in-vitro neural cells’ assembly based on iono-electronic materials and devices. These emerging devices offer basics functionalities such as memory, ion-electron signal’s transduction, and amplification paving the way to a new field of device and circuit engineering that could efficiently reproduce key biological functions such as learning and spatio-temporal processing of information. This project will demonstrate how these concepts associated to the bio-inspired computing paradigm can unlock our fundamental limitations for communicating with living neural cells. Proof of concept will show how an artificial system can efficiently send, receive and compute information from a biological one, which constitutes the basic of communication.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Improving the strategic partnership between the european union and russia' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

European strategic thinking cannot progress without clearly knowing the Russian intentions. This project is aimed at understanding and analyzing them. Based on a particular method, it is also aimed at providing relevant information for the scientific community and the decision-makers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Development of the first oral disease-modifying treatment for chronic obstructive pulmonary disease (COPD)'.

assistant: **Concept**

Palobiofarma is a Spanish biotech company with the ambition to develop new treatments for cancer and autoimmune diseases based on adenosine receptor modulation. Our compound PBF-680 is a first-in-class therapy with disease modifying effects in respiratory diseases like COPD. Over 65M        patients suffer from COPD, yet there are no approved therapies that target disease progression. PBF-680 is a unique molecule designed to specifically antagonise the Adenosine 1 Receptor (A1R). it has shown to be safe and well-tolerated in phase 1 trials and demonstrated to reduce pulmonary        symptoms and inflammation in mild-to-moderate asthmatics in phase 2 trials. With funding from the EIC Accelerator, we will demonstrate efficacy in a phase 2 trial in COPD, a market with high unmet medical need. Proven clinical efficacy will be the major milestone to raise 30M (incl 15M EIC        Equity) for a phase 3 trial, followed by an additional fund raising or IPO to independently reach market launch with PBF-680.


**Keywords:** drug development,disease-modifying,adenosine,adenosine receptor 1 antagonist,inflammation,bronchoconstriction,COPD,oral anti-inflammatory drug,exacerbation prevention
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Optimisation & Regulation of Groundbreaking Antioxidant Nanopastes and Void-control by Organics In Die-attachments'.

assistant: **Innovation**

To address the global climate crisis and achieve carbon neutrality, power electronics using wide bandgap (WBG) and ultra-wide bandgap (UWBG) semiconductors are urgently needed to replace current Si devices for higher energy efficiency. However, existing die-attach technologies derived from Si devices tend to fail at high temperatures (>175°C), slowing the development of WBG/UWBG devices. Here, we propose a novel antioxidant Cu sintering nanopaste, using reducing organics and precise void control in die attachments (DA), to produce DA with superior properties and reliability performance compared to state-of-the-art sintering pastes. This two-year project will involve multiple disciplines, including physics, chemistry, materials science, engineering, and computer science, employing methods such as multi-scale simulations, antioxidant Cu nanopaste synthesis, advanced materials characterisation for 3D microstructure construction of DA, sintering process development, and cutting-edge reliability evaluation techniques. Crucially, first-principles calculations and molecular dynamics simulations will be combined to model the evolution and diffusion/bonding behaviour of organic additives at sintering necks at the atomic level, guiding the formulation design of Cu nanopastes. In addition, a hybrid finite element method (FEM), coupled with void characteristics, microstructure, and multi-field effects (electric, thermal, and mechanical), will be developed for the accurate lifetime prediction (accuracy: >90%) of Cu sintering joints in WBG devices. The aim is to create an antioxidant Cu nanopaste capable of directly sintering a reliable DA with a shear strength of over 25 MPa at low temperatures (<250°C), in air and without the need for pressure or a protective atmosphere. This work
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mental Health Training through Research Network in Europe' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

MARATONE is a Marie Curie Initial Training Network proposal that directly addresses the need for high-level training and career pathways in mental health to increase the inter-sectorial and trans-national employability of young scientists in the academic, public and private sectors to meet the enormous challenge of the 2009 EU Parliament Resolution on Mental Health. The Resolution set out recommendations for a comprehensive and integrated mental health strategy for Europe. MARATONE is designed to address the biggest challenge to implementing this ambitious strategy: the lack of training for career pathways for young scientists in multidisciplinary mental health research.MARATONE is built on the innovative theoretical premise of “horizontal epidemiology”, the view that  psychosocial difficulties associated with mental health disorders are not exclusively determined by the diagnosis of the particular disorder in a vertical, silo-like pattern but ‘horizontally’ in a manner that reflects commonalities in the lived experience of people with diverse mental health problems. Grounded in this theoretical foundation, MARATONE’s multidisciplinary network of partners will collaboratively develop methodologies for measuring the individual and social impact of mental health disorders, so as to create strategies for the social and private sector responses to mental ill health in the form of health promotion and prevention programmes, and at the national level, strategies for human rights protections in policies and programming. The consortium will provide young researchers with scientific expertise in mental health, as well as basic technical and communication skills, including research development and management, international human rights commitments, and commercial exploitation and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The role of the E2F/DP genes in control of cell proliferation and oncogenesis' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The aim of this proposal is to analyse the role of the recently discovered transcription factors of the E2F and DP gene families in the control of cell proliferation and in tumourgenesis.In mammalian cells, ordered progression through the individual phases of the cell cycle is regulated by check-point control mechanisms, which ascertain that only normal cells will replicate, and therefore are essential for the maintenance of genetic stability. Loss of check-point control predisposes mammalian cells to cancer, emphasising the critical role of cell cycle regulators for neoplastic disease. Many genes implicated in cell cycle regulation are controlled by a group of heterodimeric transcription factors, composed of proteins encoded by the E2F and DP gene families, respectively. Thus, tight regulation of E2F/DP activity may play a key-role in oncogenesis. In a first step, it is planned to identify and characterise the main cellular target genes controlled by the E2F/DP family of transcription factors. In several model systems based on synchronised cultured cells, a thorough analysis of cell cycle regulation of gene expression through E2F/DP proteins will be performed; particular attention will be paid to the question whether differences can be found between E2F sites present in distinct target genes, or whether differential timing of E2F-driven gene expression is determined by complex regulatory elements, involving other DNA binding proteins besides E2F. To understand regulation of E2F/DP activity, the expression of different E2F and DP genes during the cell cycle and in different tissues will be analysed. In addition, we will analyse the role of post-translational modification, e.g. phosphorylation of E2F/DP proteins, and their interaction with other cellular proteins, includ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Early Star-Forming Galaxies and Cosmic Reionisation' to be submitted under Horizon 2020.

assistant: **Abstract**

Several hundred million years after the Universe was born the first stellar systems began to shine. Energetic photons from early hot stars, free from enrichment by heavy elements, reionised the hydrogen in deep space. Ambitious observational facilities will directly chart this final frontier in cosmic history and any insight we can obtain now will be invaluable in future planning. Key questions include: what is the duration of this reionisation period; was this `cosmic dawn’ a brief or extended process; and what physical processes governed the subsequent evolution of these early galaxies? This proposal aims to trace the history and physics of cosmic reionisation by fully characterising the star-forming galaxy population during and towards the end of the reionisation era. The proposed program has three complementary themes. (i) Tracing the duration of the reionisation process by analysing diagnostic nebular emission lines in the spectra of early galaxies using radiative transfer calculations; the proposed measures can be usefully compared with independent signatures of cold gas during similar epochs determined by the European LOFAR interferometer. (ii) Determining whether star-forming galaxies are the sole agent of reionisation by addressing key uncertainties relating to the number of ionising photons they produce and the fraction that escape; this requires detailed spectroscopy of gravitationally-lensed examples. (iii) Inferring the abundance of the earliest galaxies whose direct detection is beyond reach of current facilities. Stellar masses and ages of galaxies seen at later times will be used to plan surveys in time for the upcoming launch of the James Webb Space Telescope. This research program is observationally challenging but I have demonstrated the relevant tech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European NoVel Imaging Systems for ION therapy' (ENVISION) under Seventh Framework.

assistant: **Objectives**

Following the pioneering experiences which lasted several decades, particle therapy has become a recognized way of curing cancer. 2 new European dual-ion facilities (Heidelberg, Pavia) will soon become operational, followed by several others which are today at different stages of planning and construction. Hadron therapy faces the challenge of improving treatment outcomes with tools able to provide on-line a 4 dimensional feedback of the irradiation to enhance the dose conformation to the cancer volume and improve the treatment of moving organs. ENVISION is set up by 15 leading European research organisations, and 1 leading industrial partner IBA , to respond to these challenges. CERN is project coordinator and the majority of the key European experts in this field are involved, as well as the Hadron Research Facilities (Heidelberg, Pavia) who will immediately benefit from the developments foreseen in this project. A valorisation committee with members of the industrial partners has been established to maximally exploit the results. ENVISION tackles the problems of on-line Dose Monitoring and of performing accurate Quality Assurance tests by developing novel imaging modalities related to dose deposition and allow assessing the treated volume and deriving reliable indicators of the delivered dose. It concentrates on the detection of nuclear reaction products produced by the interaction of the beam with atomic nuclei of the tissue (positron emitting nuclides for ibPET, photons or light charged particles for ibSPAT). The methods are applicable to all therapy relevant ion species. The application of TOF techniques with superior time resolution to beam delivery integrated double head ibPET scanners has the potential for improving ibPET image quality. Furthermore, the real-ti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Coordination Action in R&D in Accessible and Assistive ICT' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The major aim of the Coordination Action would be to improve the overall success of Challenge 7 ICT 2009 7.2 'Accessible and Assistive ICT'.It would assist those involved in the research aspects of Challenge 7 by identifying the research and development that is needed in this field, both immediately and in the near future, by raising the level of knowledge and understanding of Accessible and Assistive ICT and by stimulating companies, research institutions and individual experts to become involved in this important area.The Coordination Action would support the corresponding STREP and IP in this research area, creating a knowledge network between them.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The cortical circuits of associative learning' to be submitted under Seventh Framework.

assistant: **Abstract**

The neocortex decodes sensory information from the external world.  Cortical circuits are organized in columns, each tuned to one specific sensory stimulus. A growing body of evidences suggests that the neocortex also participates to learning. In associative learning, a sensory stimulus that is initially neutral to a mouse, like the deflection of a whisker, acquires the emotional value of another sensory stimulus, like a foot shock, when the two are presented together. After conditioning, the mouse freezes at the deflection of that whisker alone. This form of learning correlates with changes in the barrel cortex, the region that contains the somatotopic representation of whiskers: more neurons become responsive to the conditioned whisker, regardless of their column. The emphasis on the representation of a learned stimulus could let the animal know what signal to “look for” in order to adopt rapidly the appropriate behavior next time it occurs. The paradigms inducing a conditioned behavior and the consequences for the sensory maps in the brain have been well described. Still, the specific cortical circuits involved in this phenomenon remain largely unknown. The cortical connections in the barrel cortex are segregated into two pathways, lemniscal and paralemniscal. Their distinct properties suggest they have different roles in associative learning. The recent optical technology laser scanning photostimulation permits studying the detailed diagram of functional neuronal circuits in brain slices. I will combine this approach with behavioral training to unveil the mechanisms of associative learning. I will identify the connections that are changed after conditioning and describe their plasticity mechanisms. I will also compare the ontogeny of cortical circuits with that of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Geolocalisation of Individuals in Critical Areas'.

assistant: **Concept**

If an accident or an attack occurs on a sensitive industrial site, the ability to quickly locate people is key to save lives. The existing solutions (identification badges, paper logbooks, GPS etc.) are not appropriate to answer users’ needs in this specific context. IDRE used its expertise in indoor and outdoor geolocalisation to develop an innovative solution based on LoRa-RF protocol, tags (smart electronic devices), gateways (telecommunication part), computation algorithms, a storage database and a visualization interface. The solution is enough accurate, easy to deploy and operate, scalable, low-cost, respectful of the private life and guarantees data protection, thus ideal to meet the requirements of the users (workers, security managers, decision-makers). The markets identified are composed by Seveso sites in Europe (more than 10 000 sites) and more widely by every single critical industrial sites in Europe and in the world. The project will contribute to reduce the vulnerabilities of critical infrastructures regarding natural or industrial risks, terrorism and malicious behavior, one of the major objective listed by the European Union.Before reaching the worldwide market, based on its TRL6 product and first commercial contacts, IIDRE needs to collect key information. The Phase 1 will allow to improve the knowledge of customers, to better assess the competitive environment, to refine the offer, to protect the business innovation project, to improve the commercialisation strategy, to prepare the scaling-up phase and to update the business plan. In the Phase 2, the objectives will be to proceed to the ATEX certification of the tags that will be deployed within the industrial sites, to undertake demonstrations with major worldwide stakeholders (such as MICHELIN or T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Translation and Gender'.

assistant: **Concept**

Research in the area of gender and translation is relatively recent in the field of Translation Studies. Feminist theory in translation has brought us the understanding that translation is conflictual in that it engages many of the same kinds of active identity-forming processes as other language activities. Translation can thus provide us with valuable information about practices of domination and subversion in society. In light of contemporary explorations of cultural difference in Western society and theoretical works that question the basic duality of gender, research perspectives about translation and gender are multiple and very promising since much of the terrain is yet uncharted. Reserach in the area of cultural difference and its translation is crucial in a globalized world, as we have come to understand the commerce between languages to be central to the process of communication and to achieving lasting peace. Contemporary cultures are increasingly plural and Western society, as a whole, has turned into what has been called a vast contact zone" in which intercultural relations contribute to the fabric of national cultures. The inscription of translation within contemporary writing, poetra and fiction is a clear indication that translation has now moved to the center of Western intellectual, social and cultural preoccupations. The place of women is also a major concern today in society. The aim of this project is to further advance research on translation and gender and to address some of the questions at the heart of contemporary debates. I will critically examine major contemporary perspectives on gender, culture and translation and analyze, from an interdisciplinary perspective, the works of the feminist historian Joan Scott and of the philosopher Judith But