RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'EURAXESS España Career Day' (EUESCADA).

assistant: **Innovation**

This project proposes the organization of five different career days across different regions of Spain (Andalusia, Castilla la Mancha, Basque Country, Cantabria and Zaragoza) in order to address several key issues relevant for the future of the Spanish R&D&I system:1. Promoting researcher career, in the academia and beyond2. Giving visibility to the existing European, national and regional funding opportunities3. Fostering the uptake of professional development initiatives by both, researchers themselves and institutions.4. Promoting EURAXESS as a key tool to overcome mobility barriers and support researcher career development.The fact that several career days will be executed by different members of the EURAXESS Spain Network ensures incorporating a regional ecosystem perspective to each of the events, while ensuring that the general objective of all remains.


**Keywords:** Researcher career
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'PROPROTEIN CONVERTASE FURIN AS A REGULATOR OF IMMUNE RESPONSES' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Backgound: Interleukin (IL)-12 induced T helper (Th) 1 polarization is critical for adequate cell-medated immune responses against intracellular pathogens such as M. tuberculosis. To gain insights into Th1 type immunity I performed a genome wide analysis for IL-12 target genes. The results unequivocally identified proprotein convertases (PC) furin as a novel IL-12/Stat4 target gene. Furin has been previously linked to the pathogenesis of several diseases including metastatic cancers, cystic fibrosis and infectious diseases. Consequently, furin inhibitors have been proposed as possible therapies for such diseases. I have explored furin’s physiological role in T cells using a T cell-specific furin knockout. The striking finding is that conditional deletion of furin in T cells results in loss of peripheral tolerance and systemic autoimmune disease. Objective: To evaluate the role of furin and as a regulator of immune responses; specific aims:1. Furin’s molecular mechanisms of action in T cells, 2. The role for furin in diseases of broken peripheral tolerance, 3. Furin as a regulator of innate immunity. Significance: Studying furin in T cells will help to explain the pathogenesis impaired peripheral tolerance observed in diseases like IBD and celiac disease, and understand the regulation of Th1 type immune responses that are critical in combating intracellular pathogens, such as M. tuberculosis. On the other hand, furin plays also an important role in the activation of pathogens (e.g. HIVgp160, B. Athracii toxins) and upregulates metastatic activity of cancers and pathogenesis of cystic fibrosis. This research will tackle the cell-type specific function and regulation of proportein convertase activity by identifying novel furin targets and regulators of its activity. This w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bilayered ON-Demand Scaffolds: On-Demand Delivery from induced Pluripotent Stem Cell Derived Scaffolds for Diabetic Foot Ulcers' (BONDS) under Horizon 2020.

assistant: **Objectives**

This program’s goal is to develop a scaffold using a new biomaterial source that is functionalised with on-demand delivery of genes for coordinated healing of diabetic foot ulcers (DFUs). DFUs are chronic wounds that are often recalcitrant to treatment, which devastatingly results in lower leg amputation. This project builds on the PI’s experience growing matrix from induced-pluripotent stem cell derived (iPS)-fibroblasts and in developing on-demand drug delivery technologies. The aim of this project is to first develop a SiPS: a scaffold from iPS-fibroblast grown matrix, which has never been tested as a source material for scaffolds. iPS-fibroblasts grow a more pro-repair and angiogenic matrix than (non-iPS) adult fibroblasts. The SiPS structure will be bilayered to mimic native skin: dermis made mostly by fibroblasts and epidermis made by keratinocytes. The dermal layer will consist of a porous scaffold with optimised pore size and mechanical properties and the epidermal layer will be film-like, optimised for keratinisation.Second, the SiPS will be functionalised with delivery of plasmid-DNA (platelet derived growth factor gene, pPDGF) to direct angiogenesis on-demand. As DFUs undergo uncoordinated healing, timed pPDGF delivery will guide them through angiogenesis and healing. To achieve this, alginate microparticles, designed to respond to ultrasound by releasing pPDGF, will be interspersed throughout the SiPS. This BONDS will be tested in an in vivo pre-clinical DFU model to confirm its ability to heal wounds by providing cells with the appropriate biomimetic scaffold environment and timed directions for healing. With >100 million current diabetics expected to get a DFU, the BONDS would have a powerful clinical impact.This research program combines a disruptive tech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Classical analysis, operator theory, geometry of banach spaces, their interplay and their applications.' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Collective training of graduate students and young researchers will be based on series of conferences during each annual workshop giving a global, up to date approach to one specific subject. Smaller workshops will also help young mathematicians to understand the state of the art in some specific areas. Individual training, intended to help young researchers to design by themselves long-term research projects and to get acquainted to new results and methods, will be provided through a program of postdoctoral positions and through a program of shorter visits. Predoctoral positions will help to develop training through joint advisorships between the network teams. Regular personal attention will ensure that each young researcher gets maximal benefit from theses programs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'PREparing for the Domino effect in Crisis siTuations', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

PREDICT provides a comprehensive solution for dealing with cascading effects in multi-sectoral crisis situations covering aspects of critical infrastructures. The PREDICT solution will be composed of the following three pillars: methodologies, models and software tools. Their integrated use will increase the awareness and understanding of cascading effects by crisis response organisations, enhances their preparedness and improves their response capability to respond in case of cascading failures.PREDICT project will start from a deep analysis of recent cases (over 8500 incidents worldwide), which will be accompanied with scenarios of potential crisis. Project partners will set up a generic approach (common framework) to prevent or mitigate cascading effects which will be applied in selected cases agreed with end-users.As modelling each phenomenon separately in a specific environment is not effective, PREDICT project will propose cohesive and comprehensive models of dependencies, cascading effects and common m ode failure which will include causal relations, multi-sectoral infrastructure elements and environment parameters, as well as the human factor aspects.PREDICT will deliver software tools bundled in PREDICT Incident Evolution Tool, which will consist of two core components: a Foresight and Prediction Tool (for simulation of the evolution of cascading effect and impact on multi-sectoral dependencies) and a Decision-Support Tool (for determining the best course of action and to calculate the risk associated with them).The high-quality of the developed solutions will be assured by a consortium consisting of a number of experienced partners joining research, industrial (incl. SME), and end-users approaches. End-users will be deeply involved in PREDICT at three levels:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Detecting and characterizing radio transients', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Recent technological advances place radio astronomy on the brink of a revolution, with survey capabilities about to improve dramatically. The newly completed northern hemisphere Low-Frequency ARray (LOFAR), and the future Karoo Array Telescope (MeerKAT) in the south, are two of the three new-generation radio telescopes driving this progress. It will now be possible, for the first time, to perform radio surveys sufficiently sensitive and wide to efficiently detect rapid, rare transients. Extreme astrophysical events, such as neutron star mergers and relativistic jet ejection from accreting black holes, are expected to show up amongst these radio transients. Such sourcesallow a glimpse of the laws of physics operating in conditions too extreme to be reproduced in a laboratory. The processes involved are of fundamental relevance in star and planet formation, galaxy evolution, and gamma-ray bursts. Furthermore, some classes of transients are expected to be the electromagnetic counterparts of bright gravitational wave sources. I propose to exploit the unprecedented new radio survey capacity to study high-energy processes in astrophysics. In particular, I will share an International Incoming Fellowship between the University of Southampton (UK) and the University of Cape Town (South Africa) -- two institutes uniquely well-positioned in the exciting new field of radio transients. There, I will utilize my extensive experience of optical/infraredobservational astronomy, as well as numerical modelling, to characterize a variety of radio transients, in order to secure their astrophysical interpretation. This will allow us to study normally quiescent super-massive black holes, probe relativistic accretion and jet formation, measure kinetic feedback into the ambient medium, test the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Unravelling the enigmatic origin of venom secreting cells in sea anemone' (TentaclesOfVenom) targeting Horizon 2020.

assistant: **Abstract**

Evolution of venom, nature’s most complex cocktail, has underpinned the predatory success of venomous animals. Till date, research on venom has mainly focused on how genes encoding them evolve, and our knowledge regarding the evolutionary origin of venom-secreting cells (VSCs) and their secretions, has been limited. Understanding how venom and VSCs evolve in cnidarians - one of the simplest and probably the first venomous animals, such as sea anemones is not only fascinating as it sheds light on the evolution of their ancient venom-system, but may also be instrumental in the development of efficient nematocyte (stinging-cells) based drug-delivery tools. Identifying variation in venom-composition and sites of expression across various developmental stages and between the sexes (gender-specific expression) is also an understudied topic. The former is particularly intriguing in sea anemones, as their larval stages do not feed and yet synthesize toxins. Hence, in this project I propose to: trace the evolutionary origin of known VSCs (nematocytes and gland cells) in the starlet anemone, Nematostella vectensis, by constructing transgenic reporter lines; characterize venom-secretomes of VSCs using Fluorescence Assisted Cell Sorting (FACS) to determine the contribution of each VSC towards the venom arsenal; examine variation in venom-profiles and expression sites across the developmental stages and between the sexes using ‘omics’ technologies, in situ hybridization and immunostaining; test the biochemical activities (pharmacological assays) of the major and novel toxins identified; and examine the phylogenetic histories and the molecular evolutionary regimes of the major sea anemone toxins to understand the recruitment of genes into the envenoming function in one of the first v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced environmentally friendly multifunctional corrosion protection by nanotechnology' (MULTIPROTECT).

assistant: **Innovation**

Corrosion is still one of the most serious processes for the destruction of investment goods, and in Europe far more than 100 billion of are lost every year. Presently corrosion protection strongly relies on the use of hazardous heavy metals like chromiu m. The aim of the IP MULTIPROTECT is to provide a generally applicable, highly innovative, heavy metal free, multifunctional and corrosion preventing surface technology on the basis of smart nanocomposite materials with new nanoparticles as functional des ign elements. This novel technology will not only replace presently used corrosion protection systems, but also at the same time add tailored third functions such as abrasion resistance, low friction or low surface free energy. The new technology will fu rther more establish economical and environmentally friendly production and application processes for the most important European industrial sectors. By eliminating heavy metal compounds, especially chromates from corrosion protection systems. , MULTIPROTE CT will reduce substantially the heavy metal contamination of the environment, significantly contributing to the improvement of working conditions and quality of life in Europe. Simultaneously it will improve the state of the art in corrosion protection an d contribute remarkably to the maintenance of investment value. Also new standards for the European industry will be set and the competitiveness of Europe will be substantially improved. By bundling the European efforts in the field of corrosion protection the amalgamation of national research initiatives into a common European research area will be catalysed and the idea of European integration will be strengthened.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'To Establish Concurrent Engineering Based Design for Integrated X-methodologies" for the preliminary and detailed design of aircraft sections"'.

assistant: **Objectives**

Objectives and content Competitive position of Europe's Aeronautical Industry depends on significant reductions in time-to-market and overall product costs, while enhancing quality and performance. Due to the complex and multi-technological nature of aeronautics products, there are few opportunities to achieve these reductions by simply improving existing technologies and design tools in isolation. It is necessary to adopt a fully integrated design approach through changes in the overall process to completely realize the total benefits from existing and emerging technologies. The introduction of this integrated process will benefit directly the full development phase and will leave consequently more time for the preliminary phases where 80% of the costs are committed. During these later phases, the integrated process will allow more iteration to achieve the goals of 30% in time-to-market, 20% in production costs and 40% in maintenance costs, as mentioned in the workprogramme. This stringent requirements of the Aeronautics Industry and its capability of demonstration of advanced generic technologies will enable early application of emerging technologies to other sectors. The CEDIX project will focus on the design and development phases and will concentrate on integration of existing and emerging tools and their environments. Using the experience gained on several dedicated demonstrations of these technologies within the design of typical aircraft section, the integrated -design process will be progressively refined, leading to a fully Digital Product Definition within a Concurrent Engineering approach. The technologies considered are those having the largest potential benefit. They include both definition and analysis assistances, within a Digital Pre Assembly environmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biosensors, Reporters and Algal Autonomous Vessels for Ocean Operation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

BRAAVOO aims to develop innovative solutions for real-time in-situ measurements of high impact and difficult to measure marine pollutants. The concept of BRAAVOO is based on a unique combination of three types of biosensors, which will enable both the detection of a number of specific marine priority pollutants as well as of general biological effects that can be used for early warning. First, innovative bimodal evanescent waveguide nanoimmuno-sensors will enable label-free antibody-based detection of organohalogens, antibiotics, or algal toxins. Secondly, bacterial bioreporters producing autofluorescent proteins in response to chemical exposure will enable direct detection of alkanes or PAHs from oil, heavy metals, or antibiotics, and can further assess the general toxicity of the water sample. Finally, the photosystem activity of marine algae is exploited to monitor changes induced by toxic compounds.BRAAVOO will construct and rigorously test the three biosensor systems for their analytical performance to the targeted pollutants. To enable low-cost real-time measurements, the three biosensors will be miniaturized, multiplexed and integrated into innovative modules, which allow simultaneous multianalyte detection. The modules will include all optical elements for biosensor signal generation and readout, the microelectronics for data storage, and specific microfluidics to embed the biosensors or cells, and expose them to aqueous samples from dedicated autosamplers. The modules can be used either as stand-alone instruments for specific marine applications or can operate autonomously and in real-time in an integrated form. Hereto, they will be embedded in a marine buoy and an unmanned surveying vessel. Vessels and stand-alone biosensor modules will be tested extensively a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A Paradigm Shift in Health Monitoring with Electrospun Enzymatic Neomaterials' (WOUNDSENS).

assistant: **Innovation**

Global healthcare associated with chronic non-healing wounds can be considered a main public health problem as affects up to 2% of the world population. A novel approach is needed mainly to support the quality of life of the people suffering from this silent epidemic and additionally, alleviate the impact in costs and resources for the healthcare system. Up to date, no smart bandages have made it to the real market and research state is still going on for a reliable and sensitive inspection method.  The main goal of WOUNDSENS project is to lead the development of a novel generation of wearable biosensors with a synergy of technological breakthroughs in transversal fields of knowledge. Sensor elements, for the first time, will directly become a compatible part of the wound dressing material itself resulting in enhanced wearing comfort and operability. Accordingly, they will be integratable into manufacturers' existing standard processes (suturing, embroidery, roll-to-roll). Our proposal presents a parading shift in smart wound dressings constructed on novel hollow fibers with radial bio-signaling based on engineered novel enzymes.  WOUNDSENS presents a leading-edge new technology with the design and development of innovative electrochemical materials with step forward advances in CONDUCTIVE MATERIAL, the development of electrospun neofibers and processes with leading edge methodologies on ELECTROSPINNING and the ENZYME ENGINEERING of a new family of detection biocatalysts (resurrected and extant enzymes) to secure a sensitive and reliable signal. WOUNDSENS proposal accepts the challenge of pushing forward the new technological platform to design a new concept in continuous wound control and monitoring improving the life of millions of people.


**Keywords:** Wound dressi