RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Optimize risk prediction after myocardial infarction through artificial intelligence and multidimensional evaluation' under Horizon Europe.

assistant: **Concept**

Myocardial infarction (MI) is a leading cause of death worldwide. After MI, long-term antithrombotic therapy is crucial to prevent recurrent events, but increases bleeding, that also impacts morbidity and mortality. Giving these competing risks prediction tools to forecast ischemic and bleeding are of paramount importance to inform clinical decisions, but their current precision is limited. Improve events prediction, by discovering novel and innovative markers of risk would have a tremendous impact on therapeutic decisions and patients outcome. I hypothesize that using innovative multidimensional information from wearable devices, biomarkers, behavioral patterns and non-invasive imaging, integrated through artificial intelligence computation, we may discover novel computational biomarkers of risk and improve current standards of risk prediction. In this project, I will enroll a large cohort of MI patients, whereby prospective collection of consolidated and innovative potential risk predictors will take place, in order to generate a comprehensive and multidimensional dataset. I will collect data from state-of-the-art non-invasive imaging, blood biomarkers, wearable medical devices of continuous heart electrical activity, sweat, mobility and behavioral patterns to create a large physiological time series allowing patients deep phenotyping. We will therefore analyze data leveraging artificial intelligence computation to find relevant associations with clinical outcomes, and compare new algorithms with current risk prediction tools. This research will increase our knowledge on bleeding and ischemic risk factors, enabling enhanced capability predictions models. In the near future, we hypothesize that our clinically-guided Artificial Intelligence algorithm might be integrated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Bifurcations in Several Complex Variables'.

assistant: **Concept**

This fellowship builds on the success of the applicant’s PhD thesis, where he made breakthroughs in the area of holomorphic dynamics in several complex variables. The field of holomorphic dynamics in several complex variables is a fast-growing area of mathematics, linking complex geometry, dynamical systems and many other topics. This project addresses the central question of studying stability and bifurcations of such dynamical systems under perturbation. The applicant’s foundational work has prepared the ground for significant advances in the subject, forming the basis for this project.This project specifically aims at the extension of parabolic implosion techniques (field in which the supervisor is a world-leading expert) from their natural one dimensional setting to higher dimensions (the applicant’s area of expertise). This proposal has three main directions.1 - Establish the equivalence of various possible definitions of dynamical stability in this setting, and study in depth the many differences between the one and the several complex variables setting. 2 - Extend the theory to the case of systems of saddle type, i.e., generically displaying a repelling and an attracting direction. This case contains the Henon maps (polynomial diffeomorphisms of C^2), as well as explains the local dynamics near attracting sets for endomorphisms of P^2 (C).3 - As part of the above points, contribute to a general theory of parabolic implosion in higher dimension.


**Keywords:** Holomorphic dynamics, Julia set, Fatou set, bifurcations, parabolic implosion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Controlling mesoscopic phase separation', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Conventionally, electronic device functions are generated by combining various materials, in which each material has one particular functionality. With the atomic limit as the ultimate achievable goal in sight, we try to explore methods that do not need ex tensive use of top-down nanotechnology, including lithography and deposition/etching techniques, but use device structures that are spontaneously created by nature in the general framework of electronic phase separation. Here one material can adopt more th an one electronic state, and by judicious organization of these electronic states device functions can be generated with built-in atomic precision. In a number of materials like manganites, a spectacularly diverse range of exotic magnetic, electronic and c rystal structures can coexist at different locations on the same crystal. What looks in one sense like awkward complexity is in fact a route toward engineering without the difficulties of atomic scale lithography - by manipulating the propensity of phase s eparation and phase coexistence in these materials we may make dynamically controlled functional electronic structures. The coexisting phases may form robust magnetic, electronic and crystallographic textures on mesoscopic" length scales. By controlling a n array of textured phases analogous to those in liquid crystals we may be able to control locally the electronic structure and properties without atomic-scale fabrication. In manganites, for example, a simple domain wall in the ferromagnetic metallic phas e could spontaneously develop an insulating barrier of the charge order phase creating the ultimate spin-tunnel junction. COMEPHS is the first European project that aims to concentrate all necessary resources in Europe in order to achieve functionality of mes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ultra wide band InP based quantum dot devices and applications covering the 1.4 - 1.65 m wavelength range', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

InP based InAs quantum dot structures will be developed as a new class of gain material for long wavelength telecommunication applications. Utilizing special dot properties, e.g. ultra wide gain bandwidth, high speed and low chirp, new devices and applications will be realised on this new gain material.The major goals of the project will be the development of:(a) ultra wide band InP based quantum dot laser and amplifier structures by gas source molecular beam epitaxy for 1.4 -1.65 µm applications;(b) external cavity lasers with a mode hope free tuning range up to 300 nm;(c) high speed semiconductor optical amplifiers with a gain bandwidth covering the whole communication wavelength range of 1.4 - 1.65 µm;(d)direct modulated low chirp high speed single mode lasers and;(e) single mode lasers with extended wavelengths towards 2 µm for gas sensor applications. For each topic leading expert partners in modelling, material growth, device processing and characterisation, system realisation and evaluation are contributing to this project.Objectives:- Development of InP based quantum dot structures with ultra wide gain bandwidth for the wavelength range of 1.4 - 1.65 µm;- Growth of QD laser structures optimised for the application in tunable external cavity lasers (ECLs), SOAs and direct modulated single mode lasers;- Realisation of ECLs with mode hope free total tuning range > 300 nm;- Realisation of ultra wide band and high speed SOAs (> 300 nm, 40 GBit/s, > 10 dB);- Fabrication of single mode emitting lasers based on DBR/DFB gratings with emission wavelengths covering the wavelength range of 1.4 - 1.65 µm for wavelength division multiplexing and 1.65 - 2 µm for sensor applications;- Demonstration of high speed transmission > 10 GBit/s over long distances based on low chirp di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Functional studies of the acute promyelocytic leukemia proto-oncoprotein pml' under Fourth Framework.

assistant: **Concept**

Acute promyelocytic leukaemia (APL) arises following a reciprocal translocation t(15;17) that fuses PML with retinoic acid receptor alpha (RARA). The PML-RARA fusion protein targets and disrupts nuclear multiprotein complexes called PODs, ND10 or NBs, a process which is associated with a block in myeloid differentiation leading to APL. A human B-cell cDNA library was screened for PML-interacting clones and a single positive clone (PIC1) was isolated. An antibody raised against PIC1 detects a punctate staining pattern in HeLa cells that is coincident with endogenous human PML. There is no significant colocalisation observed between the staining of PML/PML-RARA and PIC1 in an APL-derived cell line NB4, as compared to cells expressing only wild type PML. However, following all trans retinoic acid treatment of NB4 cells a significant relocalisation of PIC1 and PML is observed. The proposed project is to characterise the functional role of PIC1 and the significance of its interaction with PML in vivo. using molecular and genetic techniques. The proposed studies will allow new insights into the molecular events leading to APL.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Commercializing NuDev's Organic Permeable Base Transistors (OPBT) in full Organic photodetectors and chip-size spectrometers' (OPBT) under Horizon 2020.

assistant: **Objectives**

Within the ERC Advanced Researcher Grant “NuDev”, promising organic electronic devices especially transistors have been developed. A candidate being able to replace inorganic transistors due its outstanding features and potential low cost production process is the Organic Permeable Base Transistor (OBPT). However, electronic industry is almost completely silicon based today. Therefore, applications using organic electronic devices need to compete on the basis of superior and unique features to outperform inorganic technology. Such a potential application of the OPBT has been achieved in the lab of the PI of the “NuDev” Grant. In a recent scientific breakthrough, a novel organic photodetector technology for the near infrared (NIR) with outstanding features going far beyond the specifications of inorganic detectors has been invented. To fully exploit the advantages of this technology and to achieve integrated devices, organic electronics should be utilized for both amplification and read-out of the detectors. This way, photodetectors as well as fully integrated chip-sized NIR-spectrometers with high detectivity, high resolution, and with all the advantages of organic electronics such as flexibility and low cost mass production are possible.With this Proof-of-Concept Grant, funding is requested for combining OPBTs with the novel photodetector technology of the PI. By achieving optimized prototypes of such a structure, the Proof-of-Concept will be furnished to attract investors to commercialize this result of the NuDev Grant. The multi-billion Euro optical sensor market with its high growth rates on the one hand and the unique features of the PI’s technologies resulting in manifold application fields on the other hand are eminent preconditions for a success of the planned s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biopolymers with advanced functionalities for building and automotive parts processed through additive manufacturing' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The project aims at the valorisation of side-stream fractions and residues from agro-food production into novel polysaccharides and functional additives. These raw materials have been selected based on the advanced functionalities that provides to the polymeric matrixes. The extracted polysaccharides will be compatibilised with polyesters and polyamides and reinforced with extracted, modified and functionalised additives to obtain engineering bioplastic formulations adapted to current Fused Filament Fabrication (FFF) processes. The target of BARBARA project is the development of novel bio-based engineering bioplastic materials to validate in functional prototypes with advanced properties for building and automotive sectors.The main functionalities developed under the BARBARA approach will permit the improvement of mechanical, thermal, aesthetical and well-being properties of novel biobased engineering polymers. Selected demonstrators of direct final parts for the automotive sector and moulds and tools for hybrid manufacturing for advanced building applications. Innovations in FFF will be validated during the project in order to enhance the performance of BARBARA biobased materials through this technology and fulfil the high-requirements of the industrial sectors. BARBARA project will directly contribute to achieve SIRA´s objective in KPI 5 (4 new advanced biobased materials) and KPI 6 (3 validated consumer products through 2 novel value chains for FFF).The BARBARA consortium involves 11 partners (5 RTD, 3 SME and 3 Large Companies) accounting to 1 BIC full member, 1 in process of engaged and 3 associated, in 36-months project with a budget of 2,770,750€.


**Keywords:** Additive Manufacturing, Fused Filament Fabrication, agrowaste revalorization, polyssacharides, natura
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Understanding the development and function of cerebral cortex folding' (CORTEXFOLDING).

assistant: **Innovation**

The mammalian cerebral cortex was subject to a dramatic expansion in surface area during evolution. This process is recapitulated during development and is accompanied by folding of the cortical sheet, which allows fitting a large cortical surface within a limited cranial volume. A loss of cortical folds is linked to severe intellectual impairment in humans, so cortical folding is believed to be crucial for brain function. However, developmental mechanisms responsible for cortical folding, and the influence of this on cortical function, remain largely unknown. The goal of this proposal is to understand the genetic and cellular mechanisms that control the developmental expansion and folding of the cerebral cortex, and what is the impact of these processes on its functional organization. Human studies have identified genes essential for the proper folding of the human cerebral cortex. Genetic manipulations in mice have unraveled specific functions for some of those genes in the development of the cerebral cortex. But because the mouse cerebral cortex does not fold naturally, the mechanisms of cortical expansion and folding in larger brains remain unknown. We will study these mechanisms on ferret, an ideal model with a naturally folded cerebral cortex. We will combine the advantages of ferrets with cell biology, genetics and next-generation transcriptomics, together with state-of-the-art in vivo, in vitro and in silico approaches, including in vivo imaging of functional columnar maps. The successful execution of this project will provide insights into developmental and genetic risk factors for anomalies in human cortical topology, and into mechanisms responsible for the early formation of cortical functional maps.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ecological performance of arrhythmic plants in nature', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Timing is everything in ecology, and because plants provide the foundation for most land-based food webs, the timing of their activities profoundly orchestrates the majority of ecological interactions. Most photosynthetic and growth processes are under circadian control, but many additional processes--approximately 30-40% of all genes—are under circadian control, and yet the Darwinian fitness impact of being “in synch” with the environment has not been systematically studied for any organism.We have developed a toolbox for a native tobacco plant, Nicotiana attenuata, that allows us to “ask the plant” which genes, proteins or metabolites are regulated in particular plant-mediated ecological interactions; identify “the genes that matter” for a given interaction; silence or ectopically express these genes, and conduct field releases with the transformed plants at a nature preserve in the Great Basin Desert to rigorously test hypotheses of gene function. By taking advantage of both our understanding of what it takes for this plant to survive in nature, and the procedures established to disentangle the skein of subtle interactions that determine its performance, we will systematically examine the importance of synchronous entrained endogenous rhythms at all life stages: longevity in the seed bank, germination, rosette growth, elongation, flowering and senescence. Specifically, we propose to silence a key components (starting with NaTOC1) of the plant’s endogenous clock to shorten the plant’s circadian rhythm, both constitutively and with strong dexamethasone-inducible promoters, at all life stages. With a combination of real-time phenotype imaging, metabolite and transcriptome analysis, and ecological know-how, the research will reveal how plants adjust their physiologies to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Novel high performance injection moulding materials for cost effective secondary composite aviation parts' to be submitted under Fifth Framework.

assistant: **Abstract**

The proposers ensigage a CRAFT project addressing the Objectives of Key Action 4 'New Perspectives in Aeronautics' of the 'Growth' Programme. Competitive high performance long fiber reinforced thermoplastic composite injection molding materials will allow to reduce cost and weight of secondary aviation parts by 20 to 30 % compared to commonly used short fiber reinforced thermoplastic grades or metals without compromising mechanical performance. For aircraft industries, such cost efficient and low-weight secondary components will significantly contribute to vast reduction in CO2 emission and improvement of aircrafts' economics and safety. Technologies and methods that enable realization of this material and part concept in commercial small to large aircrafts will be developed in the project; development of aerospace performing injection molding grades, material characterization and process simulation; use of cost efficient injection molding techniques, prototype design and validation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Smartphone-based monitoring of jaundice in newborns' (Picterus).

assistant: **Concept**

Worldwide, 114.000 newborns die each year due to neonatal jaundice, a common condition caused by high levels of bilirubin. Approximately the same number of children grow up with permanent disabilities associated with brain damage when jaundice is not diagnosed early and treated. Current solutions for jaundice diagnosis require hospital laboratory facilities for blood testing and newborn monitoring by professional healthcare workers. Estimations indicate that jaundice management increases healthcare costs by €1684 million every year. In answer, Picterus have developed innovative technology based on biomedical optics and photonics complemented with machine learning algorithms that facilitate accurate remote diagnosis of jaundice by taking a simple picture with a Smartphone. Unlike the current solutions used for jaundice diagnosis, Picterus enables health personnel and parents to screen new-borns for jaundice with a tool that is reliable and comes at a low cost, regardless of the geographical location. By using Picterus, midwives or nurses doing early home-visits can safely assess the degree of jaundice in the new-born and save time that can be allocated to other needs the new-born or family might have. It reduces the need for hospital visits, and further, it reduces stress on the midwives and parents. The reduction in healthcare costs, due to remote and low-cost diagnosis of neonatal jaundice, will allow better allocation of resources in other important medical areas, but our contribution to solving the problems associated with jaundice in low- and middle-income countries (where current tools are often too expensive for a routine use) will produce a more significant impact. Picterus has the capacity to reduce outpatient visits for jaundice by 50%, with potential savings o