RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The importance of transcriptional coordination during development' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Gene expression is precisely controlled in time and space during the development of Metazoan organisms. While numerous studies have established how spatial information is integrated by gene regulatory regions, called enhancers, little is known about the temporal aspects of transcription. Most of our insights into gene regulation stem from the use of fixed preparations where timing is artificially reconstituted from different snapshots. My goal is to integrate the dynamic aspects of transcription to understand how coordination is achieved and whether it is required during development. Transcriptional coordination refers to the inter-nuclear temporal coordination in gene activation (synchrony) and homogeneity in mRNA distribution across a field of coordinately developing cells. Initially we will characterize the mechanisms of transcriptional coordination in the early Drosophila embryo, a model system which allows quantitative imaging and genetic manipulations. However the ultimate goal of the programme is to extend these analyses to later stages of development during complex tissue specification. My team will improve a newly available live imaging technique to address fundamental questions about transcriptional dynamics in a multicellular developing embryo, with three main objectives:1-examine the effects of promoter sequence and enhancer priming on transcriptional coordination. 2-analyse the inheritance of transcriptional states from mother to daughter cells and identify the bookmarking mechanisms responsible for this memory. 3-explore the functional role of transcriptional coordination for cell fate specification during cardiogenesis. Through the novel integration of the dynamic and quantitative aspects of transcription in a living organism, this study shall connect coo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '1,000 ancient genomes: gene-economy innovation in cattle, sheep and goat' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The genetic threads of goat, cattle and sheep ancestry have been woven by human breeding, environmental pressures, hybridisation and the chance effects of genetic drift. The ancestral weaves of these key animals intertwine with human creativity in the most profoundly innovative episodes of the human past. Three broad episodes of particular import were: initial domestications circa 11 kya in Southwest Asia; the intensification circa 6 kya of use of those animal products which are harvested without killing such as wool, milk and traction; and the development of exceptionally productive landraces, later formalized into breeds, in recent millennia.  However, each of these is loosely defined in time and space, the key traits are often osteologically invisible, and the vectors of causality in their virtuous cycles of gene-economy innovation are completely unknown. A combination of high coverage ancient whole genome data coupled with new analysis methods that allow efficient computation of genomewide locus genealogies will be used to untangle the threads of ancestry in sheep, cattle and goat across the whole genome in these transformative phases.  Combining these with additional low coverage genomes generated from less preserved samples will generate a total set of 1,000 ancient animal genomes. These data will be unprecedented and will allow tracking of selection at trait genes, in order to detect human agency in breeding and, in collaboration with archaeologist partners, asking are there periods and places where threads of innovation coalesce. The project will also use ancient epigenetics to explore archaeological variation in gene activation patterns and will seek to understand the problematic build up of harmful mutations that threaten livestock today. With cognate discipli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Demonstration of Sonication and Microwave Processing of Essential Chemicals' (SIMPLI-DEMO).

assistant: **Innovation**

SIMPLI-DEMO, the Demonstration of Sonication and Microwave Processing of essential chemicals project, aims at strengthening the chemical process industry ? and in particular the specialty chemicals and pharmaceuticals industries ? in its capacity to produce materials and chemicals in a sustainable and competitive way by moving from batch to continuous and modular production with flexibility being ensured by the application of alternative energy forms. Currently, the conventional technologies in the specialty and pharma sector tend to be batch-type, combined with mechanical mixing and conduction-based heat transfer, inherently leading to poor process control. SIMPLI-DEMO's vision is that of intensified processes, where alternative energy sources enable continuous and modular technologies to achieve localized actuation of multiphase, flow reactors for the purpose of high-value product synthesis. SIMPLI-DEMO focuses on the synthesis of specialty polymers and particles for use in a wide variety of every-day-use products, e.g. insulation, paints and coatings, plastics, catalysts, as well as health applications, which are important domains in the chemical industry today and into the future. Therefore, SIMPLI-DEMO advances the technology readiness level (TRL) of modular flow technology for multiphase streams involving suspensions or viscous products from TRL5 (validation in relevant environment) to TRL7 (industrial system demonstration).SIMPLI-DEMO has brought together a consortium of four end-user chemical companies, two technology suppliers (ultrasound and microwave technology), five universities and research institutions (process control & automation, reactive extrusion, oscillatory flow, ultrasound, microwaves), one SME experienced in modular automation and another SME exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Disrupting Medical Instruments for Eye Care.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Dr Kromer and Mr Dabous founded Vitreoject UG (limited liability) in Hamburg in 2018. Togetherwith our team, we aim to increase access to eye care by improving and optimising process operations.Age-related macular degeneration is the leading cause of visual impairment in the elderlyand treated with medication injected into the eye. Before the introduction of the drug, lessthan 5,000 injections were administered annually. Since then, global numbers rose to more than 90million worldwide. However, there is a lack of an optimised approach as the injection process hasmostly remained unchanged since 2004.With the Vitreoject device, we strive to disrupt the process of these injections by compromisingall needed parts into one device, making it more efficient, material-saving and above all,safer. Vitreoject is the only device that allows the game-changing localised sterilisation and integrationof all steps into one device. We develop the transformative invention with supportfrom industry leaders from the ophthalmology and economy sector, as well as a leading group ofophthalmologists. Our device has the potential to save € 249 Mio yearly in health care costs inEurope by reducing operating theatre time.The medical device market is a high risk market due to the unpredictability of the productadoption. This SME1 proposal contains a feasibility study on the technical aspects of the product,the commercial strategy, implementation and its financial viability.The original technology concept was formulated in late 2017, and a patent filed in April2018. The solution is now developed as a functional working prototype that has been validated inan experimental setting, and we would like to use this SME1 feasibility study to be able to advanceand move forward to a manufactured product in late
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Mobilising Expert Resources in the European Smart Systems Integration Ecosystem'.

assistant: **Concept**

The proposed EXPRESS CA responds to ICT-2013.3.3-b (iv) 'Supporting the development of an ecosystem for smart systems integration in Europe'. In this context, ecosystem is defined as a sustaining environment to promote economic growth, skills growth, and growth in industrial capability and global competitiveness, fuelled by the extension of knowledge, the ambitions of innovators and the business and societal needs of the community at large. The ultimate aim is to accelerate the adoption and thereby bring forward the rewards of Smart Systems Integration.<br/>Partial eco-systems exist in the form of national and regional groupings of business and public research actors, special interest groups, knowledge transfer networks, research collaborations, and the tiered supply chains of major industrial players. These groupings, although many of their members have relevant resources, are not yet marshalled to push EU capabilities in what is becoming a dominant and global industrial arena in the run-up to 2020.<br/>EXPRESS willi.   identify the existing strands of capability in groupings and value chain players from research to the marketplace,ii.  examine the gaps to be bridged andiii. create strategies and tools to complete the eco-cycles of skills>research>investment>innovation>exploitation>re-investment that are vital if the economic opportunities and societal benefits of Smart Systems Integration are to be realised.<br/>EXPRESS will also ally itself to other programmes aligned with ICT-2013.3.3-b and apply the experience of the extensive EPoSS membership, which has been translated into actions such as the Erasmus Mundus on Smart Systems Integration. This experience and capability will be deployed in tandem with the outputs of the CSA IRISS, which include a description of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Impact of NMDA receptor diversity in sensory information processing' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Synaptic variability between neuronal connections is thought to contribute to brain’s remarkable information processing capacities. In the adult brain, the density as well as subunit composition of synaptic NMDA receptors (NMDARs) varies considerably between synapses and between neurons. Despite the well documented heterogeneity of NMDARs the functional relevance of such diversity is poorly known. In the past, the functional relevance of such NMDAR diversity has been mostly considered in the context of neuronal development and long-term synaptic plasticity. Model simulations have highlighted that dendritic computations are strongly influenced by synaptic NMDARs densities and biophysical properties. Here I propose to directly study the consequence of NMDAR diversity in shaping integration properties of single neurons in primary somatosensory cortex (S1). To achieve this I will decompose this broad question into three specific tasks. 1-Assessment of NMDAR heterogeneity in glutamatergic neurons and study how this variability shapes dendritic integration. 2-Study the impact of NMDARs in signal computation among cortical interneurons. 3-Investigate the functional relationship between endogenous NMDAR modulators and NMDAR diversity. I plan to use an array of genetic, optogenetic and pharmacological tools in combination with imaging and electrophysiological techniques to achieve the proposed objectives. Importantly, in vivo electrophysiology and two-photon imaging will be used to assess the functional relevance of NMDARs heterogeneity in single neuron computational strategies during sensory stimulation. I expect to reveal that NMDAR diversity plays a fundamental role in sensory information processing by tuning the relative recruitment of inhibitory and excitatory neurons durin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Photoelectrodes that STORE LIGHT energy' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The European Green Deal requires novel solutions for renewable energy. Solar energy is not constant and hence an unstable power source owing to its intermittent nature. Therefore, storage of solar energy is an important issue. Our new technology combines solar energy conversion and storage into one, thus delivering the opportunity to exploit the benefits of solar energy conversion also beyond the availability of sunlight. Our compact two-in-one technology avoids the need to connect two separate devices, thus lowering maintenance cost and technological support, connection losses and device bulkiness, together providing a more efficient and easy solution towards the integration in the daily life or to other functional systems.The proposed technology develops a stand-alone photo-storage system that functions as a photon energy harvester and converter and in the same time as an energy storage compartment. The development of integrated solar-to-charge storage systems are of major importance to exploit the full potential of solar energy, and in the same time extending the limits of conventional energy storage systems. A photo-responsive storage system as planned in STORE-LIGHT, achieving direct and seamless solar energy conversion and storage in one single compact architecture, would be a transformative approach to power off-grid devices. Such unique photo-to-charge storage technology will ultimately affect extended application areas such as self-powered sensors or the next-generation in micro-electronics and IoT.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Superconducting Quantum Networks' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Today superconducting electronic circuits are one of the prime physical systems to explore both foundations and technological applications of quantum mechanics.The concept of processing information more efficiently using quantum mechanics has stimulated enormous progress in control and measurement of quantum electronic circuits. Now such circuits are one of the prime contenders for realizing a viable quantum information processor. Similarly, the realization of strong coherent interactions between superconducting quantum bits and individual photons has stimulated a wide range of research exploring quantum optics in these systems. In this project we plan to investigate quantum communication using superconducting circuits, an area altogether unexplored in this domain. For this purpose we will develop both hardware and experimental techniques to realize superconducting quantum networks across distances of tens of meters. In contrast to existing experiments in which quantum information is distributed over millimeter distances only, realizing such networks will allow us to address both fundamental and practical questions. In particular, we will create and test networking architectures for superconducting quantum information processors, we will create entanglement over distances on meter length-scales and perform Bell-tests of space-like separated objects with high detection efficiency. We also plan to realize and test elements for quantum repeaters and  to explore ideas of blind quantum computation. The remarkable progress in quantum technologies based on superconducting circuits, including more than 5 orders of magnitude improvement in coherence over the last 13 years, contributes to the great potential of these systems for applications. The challenging realization of quantu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Trans-Regional Researchers' Night in Public-Private Cooperation WonderWorld' in the context of a Seventh Framework call.

assistant: **Objectives**

The trans-regional (Finnish regions: Kouvola, Lappeenranta, Lahti regions) event Researchers Night has a strong aim to bring researchers into interaction with citizens and to invite all citizens and especially young people and schools to visit the open campuses that night. The Researchers’ Night intends to increase the awareness of the importance of the research, and subsequently, it is targeted to demonstrate the great importance of researchers’ work for making a better world and a better life for all. It also aims at showing, how fascinating science is. In this context especially the Marie Curie contribution to the European research will obtain an important role, but also the European academic research cooperation in general. A great diversity of technology research and humanities with a focus on partners’ main disciplines and strengths will be demonstrated to a large public in a popular way. The demonstrations will be carried out in the most different ways in laboratories and in living labs, city centers and campuses with open doors, even in IC-trains, and connected with cultural performances by local schools such as drama and music - all transmitted by video technics in open air.  Excursions, debates and panels between researchers and citizens, lectures, exhibitions, presentations, round tables and entertaining discussions, a quiz “Path of Science”, researchers' bus service ""Science Line"" and a drawing competition will be arranged around the topic. An international on-line communication with other European universities during the event is planned. All regional players are invited to demonstrate a real research-public-private partnership and to contribute to the dialog between society and research. Additionally, two other events will take place at the same time: th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Li-Ion Battery Advanced Manufacturing for Electric Vehicles' in the context of a Seventh Framework call.

assistant: **Objectives**

The global objective of the ELIBAMA project is to enhance and accelerate the creation of a strong European automotive battery industry structured around industrial companies already committed to mass production of Li-ion cells and batteries for EVs. Europe faces strong competition from Asia and the USA where more investments and production capacities for Li-ion batteries currently exist. The ELIBAMA project will exploit advanced eco-design methods of manufacturing battery cells in order to guarantee drastic gains in cost reduction and environment-friendliness across the value chain of the battery production. This will allow the production of competitively priced EVs while improving the overall safety and efficiency of the battery pack in use. Specifically, the project will focus on the development of eco-friendly processes for electrode production, electrolyte manufacturing, fast and homogenous electrolyte filling processes, cell design and assembly. Moreover, the project will develop new technologies that will allow to improve downstream quality and reduce the rate of defective products at the end of the manufacturing chain. Such technologies include introducing clean room manufacturing processes, online high resolution monitoring and inspection solutions and non-destructive testing processes for Li-ion cells. The recycling and refurbishing of end-of-life Li-ion batteries will be realized in three ways: (a) defining schemes for their safe take back and transportation, (b) developing diagnostic methods for the monitoring of used commercial batteries to assess their second life potential, and (c) defining best practices for the eco-design conception and easy dismantling of batteries in order to maximize their recycling potential. All these technical improvements will be