RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Leading-edge cooperative advances towards the next generation of concentrated solar power (CSP) technology' (CSP) under Horizon Europe.

assistant: **Objectives**

COOPERANT is at the forefront of advancing the next generation of Concentrated Solar Power (CSP) technologies by tackling typical limitations of conventional CSP facilities, such as operation at high temperatures, dispatchability, cost-effectiveness and sustainability. COOPERANT's innovations are paving the way for the uninterrupted generation of green solar power that is both dispatchable and economically viable, breaking the dependency on solar radiation. Working at high temperatures (~1000ºC) is crucial to increase efficiency and cost-effectiveness; however, harsh operating conditions present significant challenges in terms of material availability, corrosion, system design and performance limitations. In alignment with the SET-Plan for CSP, the proposal incorporates three cutting-edge solutions at technological, digital and transference levels, that synergistically cooperate to address them: -COOPERANT CSP-TES system: a groundbreaking concept showcasing a high-performance volumetric solar receiver with custom-designed cellular morphology coupled with a hybrid packed-bed Thermal Energy Storage (TES) system. Enhanced phase-change materials and solid-state mixtures will be formulated and characterised to serve as high-temperature storage mediums. Heat transfer enhancement and containment techniques will be applied to ensure operation safety and long-lasting durability. -COOPERANT-AI TOOL: including real-time monitoring, reinforced learning-based control, scalability and replicability features. A holistic orchestration by sophisticated artificial intelligence digital tools to assist with feasibility, replicability, and scalability paths towards commercialisation. -COOPERANT-TRANSFER: a knowledge transference programme with a multi-stakeholder approach, engaging closely
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Research capacity building and upskilling and upgrading the research team in NUBiP (Ukraine) on agroecological intensification for crop production'.

assistant: **Concept**

The project objective is to strengthen the research capacity of NUBiP team and create a networking platform for best practices about agroecological intensification to uplift the scientific excellence and translational skills of NUBiP team.The specific objectives are : O1. Enhance research skills for stimulation of scientific excellence and innovation capacity of NUBiP in UkraineO2. Exchange of knowledge and best practices through joint proposals, publications and visits to enhance scientific reputationO3. Implement field trials on combined effects of biostimulant application and cereal-legume intercrop on productivity and provision of ecosystem services  O4. Communication, dissemination and exploitation of project outputs on agro-ecological intensificationThe main results  are1.Improved research competence and profile of 5 researchers from the coordinating NUBiP team 2.Exchange of best practices to upskill and upgrade researchers from NUBiP3.Productivity and ecosystem service assessment of combined effects of biostimulants’ applications and cereal-legume intercrops 4.Synthesis of best practices on agro-ecological practices for dissemination and outreach  ECOTWINS will enhance the research competence and excellence, as well as management and translational skills of NUBiP coordination team, by strategic and progressive transfer of knowledge and skills from the three EU partners (UCPH, SLU, ESCI). Furthermore, this project will strengthen NUBiP existing networks with other Ukrainian and international institutions by widening its research outlook and network with the support of EU partners. As a test bed and model sustainable cultivation site, ECOTWINS will also have an explorative agro-ecological research as a common theme across the WP activities using local resources. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High performance simulation of internal combustion engines' (HPS-ICE) under Fourth Framework.

assistant: **Objectives**

The overall goal of the project is to integrate the simulation of fluid flow, mixing and heat release in internal combustion engines into the development cycle through the use of HPCN.In order to make further advances in the development of piston engines, including the lowering of harmful emissions and the improvement of fuel economy, it will be necessary to make increasing use of computational fluid dynamics. At present there are two main obstacles to transferring existing relevant basic research to development centres. The first obstacle is the long computational time currently required for the realistic simulation of time-dependent flow fields and turbulent combustion under real-engine conditions. The second obstacle is the time and cost required to generate, modify and control the computational grid. The aim of the project is to demonstrate real-engine simulations within one week. These simulations will include the necessary pre- and post-processing and should allow an accurate prediction of velocity fields, turbulence, fuel distribution at ignition point and heat release. This is the necessary condition for achieving the required improvement in the development processes of internal combustion engines from the standpoint of engine designers. From the automotive companies' viewpoint, the reductions in time, effort and cost to achieve those improvements in engine performance required by market competition and government legislation will represent a major advance and will contribute to their competitive advantage. http://www.uni-stuttgart.de/RUSuser/vis/hps-ice.html
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'mRNA regulation of actin binding proteins', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Cell shape is mostly controlled by the actomyosin cytoskeleton, composed of actin, myosin and multiple actin binding proteins (actin-BPs). Actin-BPs affect actin organisation and actomyosin contractility. While the mechanism of mRNA regulation of actin itself is well characterised, there is little research on the mRNA regulation of actin-BPs. Recently, the host lab discovered a novel mechanism of dose co-regulation for protein groups containing similar multivalency domains, termed interstasis.  Certain actin-BPs contain multivalent C-rich regions making them a candidate protein group for mRNA regulation via interstasis. I propose to investigate the mechanism of mRNA regulation of actin-BPs, in particular those with C-rich mRNA sequences, and the possibility of feedback regulation.I will firstly identify RNA binding proteins (RNA-BPs) binding and regulating mRNAs of actin-BPs among RNA-BPs previously detected at the actin cortex and cell protrusions. I will specifically focus on identifying RNA-BPs binding to C-rich actin-BP mRNAs. I will identify the mechanism of action of these RNA-BPs via ribosome profiling, iCLIP, and smFISH. In the second part of the project, I will investigate whether C-rich actin-BPs mRNAs can be co-regulated and a potential feedback mechanism. In particular, I will use combinatory multivalency reporter to ask whether actin-BPs can be co-regulated via interstasis. Finally, I will connect mRNA regulation of actin-BPs to the actin organisation and processes affected by changes in actin organisation such as cell division and migration.  To this aim, I will modulate the levels of RNA-BPs and actin-BP mRNAs and use microscopy to image the effects on the actin-driven processes.Together, I aim to further unveil molecular regulation of the actin networks
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A cold-atom photonic-crystal-waveguide interface for efficient quantum operations in single pass' under Horizon 2020.

assistant: **Concept**

Deterministic nonlinear operations between single photons that are at the heart of numerous quantum information protocols require strong interactions between photons and quantum emitters. By combining cold atoms and slow-mode photonic-crystal waveguides, the goal of this project is to develop a novel platform to implement such operations by strongly coupling a photon with atomic ensembles in single pass, that is without the use of an optical cavity. Transverse optical confinement and slow group velocity are the key ingredients in this novel waveguide-QED approach, with applications in integrated quantum technologies, quantum non-linear optics and state engineering. This platform, based on a new and promising combination of photonic-crystal geometry (W1) and material (GaInP) will not only provide superior figures of merit and scalability than in free-space implementations, but also tailored functionalities not achievable in current physical interfaces. This project uniquely combines atomic physics, quantum optics and nanophotonics and will ideally prepare the applicant for a future career as an independent research group leader.


**Keywords:** Cold Atoms, Single Photon, Photonic Crystal Waveguide, Waveguide-QED
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Automated Urban Parking and Driving' in the context of a Horizon 2020 call.

assistant: **Objectives**

Automation of individual transport systems is considered an up-and-coming prospect with the potential of greatly mitigating many of the challenges associated with intensified urbanization, while at the same time offering additional benefits for the citizens and drastically increasing overall street safety. However, due to the lack of maturity of involved key technologies and persisting legal limitations, full automation of on-road driving remains a longer-term vision, particularly in urban environments.The goal and ambition of UP-Drive is to address these technological challenges through the development of an automated valet parking service for city environments, aimed at relieving a car driver from the burden of finding a parking space in city centers. Instead, the fully automated car navigates on its own through urban neighborhoods, finds a parking space and returns on-demand.Creating such a system requires mastering all key technologies essential to automated urban driving beyond the current state-of-the-art: complete round-view perception of the vehicle environment, robust lifelong localization and mapping, sophisticated understanding of complex scenes as well as aggregation and integration of long-term semantic data over a cloud-based infrastructure. With this, we ensure that the research and development carried out in this project will directly be applicable to other urban driving use-cases such as driver assistance and safety systems on the one hand, and on the other hand to the transportation for elderly and citizens with handicaps, last-mile delivery of goods - and ultimately fully automated urban driving in general.The consortium will continuously integrate the research and development from all partners into a fully functional vehicle platform and will showcas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enhancing MLTC management for HIV populations through Implementation research, evidence-based interventions, and integration of NCD care in LMIC contexts with a focus on Viability and Equity.' (HIVE).

assistant: **Concept**

HIVE adopts an Implementation Research Framework to support integrated care and management of HIV and concomitant NCDs leveraging an mHealth application tailored for the (self-)management of multiple long-term conditions for PLWH. This initiative also incorporates interpersonal counselling (IPC) for vital psychosocial support and integration of NCDs care into HIV clinics. The mHealth application will build on an existing digital health tool developed by HIVE partner, Columbia University, which has already been piloted in several low- and middle-income countries . HIVE aims to extend and customize the application for diverse high-income countries (HICs) and low- and middle-income countries (LMICs), including Kenya, Kazakhstan, Greece and Malta, addressing the unique needs of PLWH in different disease settings and cultural contexts. The goal is to mitigate the disparities in access to health for PLWH in different countries as well as the inequalities that are being faced among different population groups within each participating country.


**Keywords:** HIV, Multiple Long-Term Conditions, mHealth, Mental Health, Non-Communicable Diseases Care, Equity, Sustainability, Diversity, Culture Sensitive, Evidence-based Interventions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Open Many-body Non-Equilibrium Systems' (OMNES), addressing dissemination and exploitation.

assistant: **Impact**

We shall study non-equilibrium many-body quantum systems, considering local interactions in one or two spatial dimensions in situations where the generator of time evolution in the bulk of the system is unitary whereas the incoherent processes are limited to the system's boundaries. We foresee a mathematical theory of dynamical quantum phases of matter with applications in the theory of quantum transport and nanoscale devices that manipulate heat, information, charge or magnetization. Our steady-state setup represents a fundamental paradigm of mathematical statistical physics which has been pioneered by the PI, who gave the first explicit solution for boundary driven/dissipative strongly interacting many-body problem (XXZ spin 1/2 chain) which answered a long debated question on strict positivity of the spin Drude weight at high temperature. The main focus of OMNES will be centered on exploring the following three interconnected pathways: Most importantly, we shall develop a general framework for exact solutions of non-equilibrium integrable quantum many-body models, in particular the steady states and relaxation modes, and develop quantum integrability methods for non-equilibrium many-body density operators. Fundamentally new concepts which are expected to emerge from these studies, relevant beyond the context of boundary-driven/dissipative systems, are novel quasilocal conservation laws of the bulk Hamiltonian dynamics. Second, we shall investigate relevance of exact solutions in physics of generic systems which are small perturbations of integrable models and explore the problem of stability of local and quasilocal conserved quantities under generic integrability-breaking perturbations. Third, we shall formulate and study the problem of quantum chaos in clean lattice
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Molecular basis of IGF2BPs-mediated lncRNAs degradation', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) constitute a conserved family of oncofetal RNA binding proteins (RBPs) important in embryonic development, and whose expression in tumours is strongly correlated to cancer dissemination. There are three isoforms in mammals, IGF2BP1-3, which regulate mRNA transport, translation, and RNA stability, in a RNA target-dependent manner. Recently, it has been reported that IGF2BP1 interacts with HULC long non-coding RNA (lncRNA) in hepatocellular carcinoma cells and mediates its degradation through recruitment of CCR4-NOT deadenylation complex. Interaction of IGF2BPs with lncRNAs has been described in the past, however, this is the first time that IGF2BPs has been implicated it its turnover.The objective of this proposal is to study how IGF2BPs promote the turnover of lncRNAs. We will use iCLIP assays in a novel and comparative fashion to define the ensembles of IGF2BP1-RNA targets directed to degradation through recruitment of CCR4-NOT complex. We will take advantage of the host group understanding of protein-RNA interactions in the IGF2BPs system and of the experience of the researcher with the CCR4-NOT deadenylation machinery, as well as of an ensemble of techniques from cell to structural biology, to explore the novel IGF2BP1-CNOT1 interaction and rationalize RNA recruitment and degradation.LncRNAturnover will provide a first important example of how RBPs regulate the turnover of lncRNAs, an area of RNA biology which is very poorly understood but important for the regulation of the expression of genes crucial in cellular proliferation and differentiation. Our research will also explain the molecular mechanism and selectivity of IGF2BP1-mediated RNA degradation.We expect our research will help design new strategies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Precision Medicine via Diagnostic Enzyme Activity Testing' (PreMeDosE), addressing dissemination and exploitation.

assistant: **Impact**

PreMeDosE aims to ascertain the technical and commercial viability of a novel cytochrome P450 (CYP) enzyme activity assay, to enable truly personalised drug dosing for the first time. The CYP enzymes are responsible for the elimination of the majority of therapeutic drugs from the body. However, inter-individual variation in CYP activity leads to personal differences in drug elimination kinetics, both toxic accumulation (too slow elimination) and loss of therapeutic efficacy (too rapid elimination). The resulting adverse drug reactions have considerable clinical as well as economic consequences, accounting for ~5% of hospital admissions and increasing the mean stay from 8 to 20 days, and thereby affecting a patient’s quality of life and increasing healthcare costs. The inter-individual variation in elimination kinetics can have a genetic origin (some critical CYP enzymes are polymorphic), but substantial variations also arise from external factors, such as dietary agents, age, sex, disease state, and drug-drug interactions. Presently, only genetic variation can be measured but is not routinely recommended for clinical implementation because of the limited clinical utility. The PreMeDosE microfluidic assay permits for the first time measurement of the impacts of both genetic and external factors. The PreMeDosE assay permits direct measurement of CYP enzyme activity from a very small (biopsy-scale)  liver sample, providing personalized information of drug elimination kinetics and thus paving the way to customized drug dosing. PreMeDosE assay fits standard well plate technology so it is easily implemented in routine laboratory flow. Within this project, we will optimize and validate the PreMeDosE technology with the aim to ascertain its technical and commercial viability.