RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Liquid Phase Electron Microscopy of Magnetite' (LPEMM) targeting Horizon 2020.

assistant: **Abstract**

Liquid Phase Electron Microscopy (LPEM) is a state-of-the-art analysis technique for real-time observations of nanoscale processes in liquids. As a research tool, it is unique in its ability to observe material formation pathways in complex environments. Consequently LPEM is expected to solve grand challenges in materials science; however, several obstacles need to be overcome before this technique can fully impact the whole materials science community. In the proposal LPEMM, I intend to address these multidisciplinary problems through the study of an ideal, but industrially relevant material system, namely magnetite. Magnetite is the most magnetic naturally occurring substance on earth, and of great technological interest in areas such as water purification, biomedicine and data storage. The magnetic properties of magnetite are determined by particle size, shape and organization, which in Nature is controlled though the process of biomineralization. In Magnetotactic bacteria biomineralizations occurs in confined, complex compartments called magnetosomes. I will replicate this environment inside the electron microscope and record the process with nanometer resolution, providing the first ever real-time videos of the magnetite formation. In collaboration with an industrial partner FEI Company, I will determine optimal microscope configuration and imaging conditions for LPEM based on particle motion, contrast and liquid layer thickness. The proposed research will provide a unique insight into magnetite biomineralization allowing the design of new synthetic routes to form magnetite under ambient conditions, with control over particle size, shape and organization. In a broader context summation of this research will provide a clear platform for the investigation of material
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cardiovascular-consistent approach for refined simulation' in the context of a Sixth Framework call.

assistant: **Objectives**

Cardiovascular disease is the biggest cause of morbidity and mortality in Europe. Its study brings together experts from the physical and life sciences with clinical practitioners in the search for understanding of the complex processes underpinning cardio vascular physiology. This proposal seeks to develop an energetically consistent framework into which models of disparate processes on disparate time and length scales can be integrated to further this understanding. It would be unrealistic to expect this programme to pull together all multidisciplinary threads, but it can develop a coherent framework for cardiovascular simulation. It will focus on the integration of bond graph elements, representing system characteristics in a coherent and intuitive manner, with 3D computational models, providing detail of local stress distributions and flow structures. The bond graph framework offers the facility for ready and consistent integration of descriptors of mechanical, chemical, electrical and biological events.The simulation environment will be exercised in the study of an important problem in cardiovascular mechanics, namely the evaluation of closure forces of heart valve prostheses. For mechanical heart valve prostheses these can be very high, and can lead to early failure and, in some cases, to local cavitation in the blood. There are currently no models that integrate the mechano-chemical characteristics of the ventricular wall with local haemodynamics to compute closure forces. All current sophisticated models (including fluid-solid interaction) require explicit definition of either ventricular motion or pressure. The success of this proposal hinges on the combination of the expertise of the applicant, in bond graph modelling, with that of the host institution , in fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evaluation of the prevalence of the coeliac disease and its genetic components in the european population' (1998-2002).

assistant: **Concept**

TECHNOLOGICAL PROBLEMCoeliac disease is an autoimmune type disease characterised by intolerance to gluten (gluten is a major food ingredient extracted from cereals like wheat, rye and barley). In genetically susceptible individuals, gluten ingestion results in intestinal mucosa damage and malabsorption of essential nutrients.The coeliac-EU cluster groups together three research programmes with complementary scientific objectives: To establish the prevalence of oeliac disease in a large European population.To characterise the genetic basis of this common food intolerance.To identify factors involved in the gluten-triggered pathogenesis of mucosal damage.EXPECTED RESULTSThe epidemiology study will :Provide an estimate of the prevalence of oeliac disease in Europe.Allow identification and early treatment of 'silent' oeliac people who are so far not detected.The genetic study will :Identify association(s) between gene(s) and the oeliac disease.Clarify the contribution of the HLA genetic components and their association with other (non-HLA) genetic markers.The pathogenesis study will :Characterise features of damage in the oeliac mucosa.Provide information on factors involved in the pathogenesis of mucosal damage, in particular on T cells involvement.APPLICATIONSA new simple serological diagnostic test, suitable for large population screening and allowing an easier and earlier detection of the disease, will be validated.A non-invasive genetic test based on DNA analysis may potentially be developed in the future. New therapeutic strategies, for instance based on immuno-modulation, may potentially be developed in the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Trans-Atlantic Study of Calanus Finmarchicus' (TASC) under Fourth Framework.

assistant: **Objectives**

The objective of the international GLOBEC Programme sponsored by SCOR,IOC and ICES is to understand ocean ecosystem dynamics and how they are influenced by physical processes so that the predictability of populatior fluctuations in a changing global climate can be assessed". The aim is to promote large scale research into the effects of ocean climate change around the world. The programme of work in the northeast Atlantic presented here represents a coordinated European response to the GLOBEC initiative. Links with equivalent studies in the northwest Atlantic will be carried out through ICES. The objective is to understand the physical and biological processes which control the population dynamics of the copepod Calanus finmarchicuc a key zooplankton species in the northeast Atlantic. Establishing the 1relationship between the physical and biological factors affecting annual recruitment and reproduction of this species is an essential step towards predicting the consequences of future climatic change. Hypothesis developed to address the linkage between physical processes and C. finmarchicus population dynamics are: 1. The interaction between vertical migrations and shelf edge hydrodyna mics determines the ability to C. finmarchicus to seasonally colonise northeast Atlantic shelf ecosystems from overwintering depths in Norwegian Deep Water off the shelf edge. 2. Year-to-year variations in the timing and dynamics of shelf populations are dependent on oceanic and shelf scale forcing. 3. The deep circulation in the Norwegian Sea Basin and overflow into the north Atlantic is responsible for a "teleconnection" between C. fin marchicus summer populations in northeast Atlantic rim ecosystems. 4. Latitudinal gradients in abiotic conditions and interactions with predators control
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Identification of new angiogenic regulatory events, markers and targets for anti- or pro-angiogenic therapies (ANGIONET)'.

assistant: **Innovation**

A wide range of common and lethal pathologies such as cardiovascular diseases, tumour growth and metastatic spread, are linked to the disruption of the angiogenic balance. The antiangiogenic treatments currently in clinical trials for cancer generally target a limited number of events involved in the angiogenic process. There is a pressing need to expand the number of therapeutic targets in this area. The consortium partner laboratories contribute expertise on a wide spectrum of cellular and in vivo models, providing a comprehensive representation of specific steps in neovascularization. These models will be processed by genomics analysis and promising genes will be pre-selected in vitro. The selected genes will be assessed and compared in the set of physiological and pathological models. This strategy will lead to the identification of novel critical genes and define their role in angiogenesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Forum Scientium Sensing Science Early Stage Research Training Centre' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The proposed 'Sensing Forum' at Link ping University, Sweden, is primarily built on two existing organizations. Forum Scientism that is a multidisciplinary graduate school within Life Science Technologies and Biomedicine with an emphasis on Sensing Science, and S-SENCE that is a Swedish Centre of Excellence in Bio- and Chemical Sensor Science and Technology. The research in the early stage-training programme is chosen to allow a multidisciplinary approach to scientific questions within the sensing science area. The main research area concerns multisensor systems, e.g. electronic noses and electronic tongues. In these, signals from sensors with different sensitivities are combined to a response pattern specific for e.g. an odour. Biosensors based on synthetic peptides, as well as DNA and protein arrays using molecular electronics are examples of research projects well aimed for the students participating in the proposed programme. The work includes both exploratory projects as well as application driven projects with industry. In all areas there are ongoing high-level research, which will secure that a fellow choosing to work in any of these areas, will be given excellent supervision and support. All students in the training programme will take part in the regular activities of the graduate school in which altogether 57 PhD-students have so far been admitted. Of these five were/are from other European countries than Sweden. It has also hosted so far seven students participating in the Marie Curie Training Site that started here during end of year 2000. In the beginning of 2004, there are 22 PhD-students in the graduate school. All activities are done using the English language. Examples are weekly meetings, study visits to interesting companies, interesting seminars, tra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Migrating commercial law and language. Rethinking lex mercatoria (11th-17th century)' under Horizon 2020.

assistant: **Concept**

MICOLL will analyze the development of commercial law by means of a tool almost ignored in this field: historical linguistics. The borrowing and transfer of legal terms will be carried out through a comprehensive and systematic investigation of medieval and early modern legal sources, in particular commercial letters, contracts and statutes. Even though legal historians tend to deny the effectiveness of a body of customary laws uniformly adopted across medieval and modern Europe, the “myth” of the ancient lex mercatoria continues to provide historical legitimacy to the supporters of corporate self-regulation. According to a widespread historiographical topos, merchants all over the world “spoke the same language” when it came to what was important for them: to make profits. As legal institutions are represented by technical legal words, an analysis of the terms merchants actually used is a powerful and never attempted way to verify the impact of merchants’ migrations on the development of commercial law, which had, in its turn, tremendous effects on social and economic history. The center of this project will be Venice, for several centuries the mandatory stop for merchandise coming from the East and directed both to northern Europe and to Genoa, from where men and goods would reach other trading centers (e.g., France and the Iberian peninsula). Our time-frame spans from the “commercial revolution” of the 11th century to the beginning of the modern period, when the new dynamics of transoceanic trade left Venice at the periphery of a world that was changing its very dimensions.  Did merchants actually use the same legal terms in different geographical areas? And, above all, did they grant these words the same legal meaning? MICOLL will answer these questions by means of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Computational Hematopathology for Improved Diagnostics' (CompHematoPathology), addressing dissemination and exploitation.

assistant: **Impact**

Identifying hematologic malignancies still relies on the time-consuming and subjective visual assessment of images. Every day, cytologists and pathologists are confronted with rare diagnostic cells, ever-increasing image data, and heterogeneous disease manifestations. Although we understand blood better than any other human tissue, we are unable to quantitatively predict a patient’s blood dynamics from a measurement. Diagnosis thus depends on rough staging schemes and the expertise and intuition of the clinician.In my proposal, I address these challenges by establishing computational hematopathology, a combination of artificial intelligence algorithms and mathematical models that will boost the currently prevailing manual assessment. Based on my experience in using these methods for scrutinizing stem cell differentiation I will combine the power of deep learning and mathematical modeling with digitized and expertly annotated image data. My unique approach enables me to design and parametrize a data-driven model to predict hematopoietic dynamics in health and disease. Since the interpretation of digitized slides is becoming the clinical standard, novel algorithms for standardized disease classification and improved diagnosis are critically needed now. This interdisciplinary project merges methods from digital pathology, machine learning, image processing, and mathematical modeling. ComHematoPathology will provide novel approaches and software tools for automated classification of hematopathology image data, allowing for reproducible and precise diagnosis at an unprecedented level. This will increase throughput and standardize the diagnosis of blood diseases and will thus improve the treatment of patients suffering from hematologic malignancies.


**Keywords:** Computatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Fluvial Meta-Ecosystem Functioning: Unravelling Regional Ecological Controls Behind Fluvial Carbon Fluxes' (FLUFLUX), addressing dissemination and exploitation.

assistant: **Impact**

Fluvial ecosystems are an important element in the global carbon cycle metabolizing large amounts of terrigenous organic matter (tOM). This contributes to CO2 evasion fluxes that are under continuous reevaluation at the global scale. In contrast, research on the underlying processes is concentrated at the local ecosystem scale. This scale-gap seriously hampers process understanding across scales, limits upscaling accuracy, and reduces our scope of reaction strategies.Here, I suggest ground-breaking research on ecological processes at the intermediate ‘regional’ scale of the ‘fluvial network‘ to create a deeper mechanistic understanding of biogeochemically relevant carbon fluxes. My starting point is trifold: (1) detrital tOM has extremely high molecular-level diversity that requires consumers of equally high biodiversity for efficient respiration; (2) exactly this biodiversity of heterotrophic microbes, fungi and insects is constrained by metacommunity dynamics unfolding at a larger regional scale; and (3) the rules by which the conspicuously dendritic structure of the fluvial network shapes a metacommunity differ fundamentally from those governing regional diversity patterns of tOM resources.I hypothesize regional carbon dissimilation in ‘fluvial metaecosystems’ to be the interactive product of spatially partitioned resource and consumer diversities. I posit that this coupling of metacommunity structure to metaecosystem function is influenced by fluvial network topology, anthropogenic network fragmentation, and terrestrial matrix variation. Research will combine experiments in innovative lab-scale metaecosystems, spatially explicit modelling using cellular automata, and field studies spanning gradients of regional anthropogenic impact in real fluvial networks. I expect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Network of centres of excellence interfacial effects, novel properties and technologies of nanostructured materials""'.

assistant: **Concept**

The application is for 3 workshops of the network. The first workshop is going to take place in Krakow, 18 September, 2002. The second workshop is going to be in Luanne, in September ,2003. The 3 workshop will take place in 2004 in one of the Baltic countries. The most important results that are expected are new innovative research ideas and cooperation links between network partners, which will also permit to the network members to participate in EC research projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Marine Ecosystems Regulation: Trace Metals and Carbon Dioxide Limitations' (MERLIM) targeting Fourth Framework.

assistant: **Abstract**

Principal investigators: prof.dr. H.J.W. de Baarl, dr. K.R. Timmermansl, dr. U. Riebesell2, dr. D. Wolf-Gladrow2, dr. C.S. van den Berg3, dr. M. Whitfield4, dr. R. Geider4, dr. M. Fontugne5. ABSTRACT. Trace metal and carbon dioxide uptake can limit phytoplankton growth rates in marine ecosystems. Using new analytical approaches and methodologies, the relationship between algal growth and the biological availability of trace metals and carbon dioxide will be unravelled. Objective is to elucidate the relationship between algal gLowth rate and the availability of trace metals and carbon dioxide in seawater, including synergistic effects relating to trace metal and inorganic carbon co-limitation. The analysis of trace metal and CO2 biological availability will involve the determination of the chemical forms of iron (Fe), zinc (Zn), and cobalt (Co), their exchange kinetics and diffusive transport rates, as well as an assessment of the significance and functioning of carbon-concerltrating mechanisms in marine phytoplankton communities. These questions will be addressed by combining newly developed electrochemical methods with physiological and molecular diagnostics capable to assess the nutritional status of phytoplankton. Specific objectives are as follows: a) to determine the biological availability of trace metals (Fe, Zn, Co) throug measurements of speciation, complexation and dissociation/association kinetics, with the purpose of developing a model on trace metal mass transport; b) to develop, calibrate, and apply molecular and physiological diagnostics with which to characterise the nutritional status of model phytoplankton species and to detect trace metal and CO2 limitation; c) to investigate synergistic effects of trace metal and carbon dioxide limitation and physiol