RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Spanish permanent multilateral Smart Finance FORUM for Smart Buildings' to be submitted under Horizon 2020.

assistant: **Abstract**

In extension of the work of the Sustainable Energy Investment Forums,AÚNA proposes to create in Spain a permanent, multilevel, multilateral discussion FORUM, fully focused on sustainable building financing, for the effective and wide implementation of the Smart Finance for Smart Buildings initiative, with the following differential characteristics:•From the building renovation sector, with a systemic approach led by Green Building Council España (GBCe)•Based on GBCe’s knowledge in the field, from the GTR Reports to the national and international coordination of stakeholders’ collaborative processes of H2020 BUILD UPON projects, and the launching in Spain of the green mortgages initiative EeMap, which put GBCe in a unique position•Able to bridge the gap between renovation and financing, by the incorporation at a leading discussion level of the most advanced players on all the interrelated aspects of financing, facilitated by the present openness of the financial world•Oriented to a shared understanding, to draw significant advances in terms of ideas, to be incorporated by the stakeholders to their practices and policies•Integrally based on the financial and stakeholders platforms aspects of the Commission Recommendation on Building Renovation•Totally aligned with the Spanish Long Term Renovation Strategy, of which it becomes a key stream in continuation of the work already started, with full support from the Interministerial LTRS group of Spain (ERESEE)•Four rounds of growing practical definition and outreach, with clearly defined progress indicators: a) preparatory; discussion FORUM definition and planning, b) extension to the wide renovation sector, c) citizenship outreach and d) shared contribution to the Spanish NECP and the ERESEE 2023•Liaising with the SEIF organiz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of small modulators of gene activation and repression by targeting epigenetic regulators' (SMARTER), addressing dissemination and exploitation.

assistant: **Impact**

The identity of a given cell within a metazoan organism is primarily defined by the expression pattern of its genes. The activation and repression of particular genes is tightly regulated by the concerted action of transcription factors that recognize and bind specific DNA sequences within regulatory regions. Work done over the last 20 years established this basic regulatory mechanism of gene activation and repression, while recent experiments exposed an additional layer of regulation involving modifications of DNA and bound histones. These modifications are involved in cellular inheritance of transcriptional states through cell division and development and as they are not coupled to DNA sequence are referred to as epigenetic.Many factors that impact on epigenetic phenomena are clearly distinct from basic transcription factors and are involved in regulating chromatin structure. Modulation of chromatin structure is frequently achieved by intrinsic enzymatic activities that either mark particular regions within the genome for activity or repression or use the hydrolysis of ATP to remodel nucleosomal arrays. This change of gene expression patterns in response to external and internal signals has a major influence on stem cell differentiation, the maintenance of tissue integrity and the adaptation of organisms to environmental changes.Recently small molecules that target histone deacetylases have been used for cancer treatment, which has opened new avenues in therapeutical research. However, small molecules targeting epigenetic regulators have so far not been the major focus of drug discovery efforts. The suggested STREP proposal aims at the development of such compounds, which is the primary mission of Chroma, the SME participating in the consortium.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Post-transcriptional regulation of effector function in T cells by RNA binding proteins' (PRinTERs) under Horizon 2020.

assistant: **Objectives**

CD8+ T cells are critical to fight infections and to clear tumor cells through the production of inflammatory cytokines and cytotoxic molecules. These effector molecules must be tightly controlled: too little leads to the inability to control the pathogen, and too much can result in a life-threatening cytokine storm and tissue damage. While transcriptional control of effector genes is well-studied, regulation at the levels of RNA stability and translation efficiency by RNA-binding proteins (RBPs) has remained underappreciated. We recently found that several cytokines are tightly regulated through these processes, and we identified ZFP36L2 as one of the responsible RBPs. However, much is still to be learned about the underlying molecular mechanisms. Moreover, there are >1000 putative RBPs, and a systematic analysis of their regulatory activity in T cells is lacking, particularly with regard to the control of effector proteins. Here, we will use a combination of mouse genetics, and molecular and cellular biology to gain a deep understanding of the control of cytokine production by RBPs, using ZFP36L2 as a paradigm. Next, we will take a novel, highly sensitive proteomics approach to systematically identify the RBP repertoire in resting and activated primary human T cells. Complementary functional screens will identify those RBPs that control specific effectors. Selected RBPs identified in these screens will be studied in-depth to understand their roles in T cell responses to acute infection and in tumor models. Lastly, we will define how RBPs can imprint and/or maintain the killer phenotype of human CD8+ T cells. This research will significantly advance our understanding of post-transcriptional regulation of T cell effector activity, and it should help us to develop novel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Decoding Hox specificity from mRNA processing networks' under Horizon 2020.

assistant: **Concept**

Cell fate decisions is governed by the fine-tuned regulation of gene expression in all living organism. It is mostly realized by the cell-type specific assembly of regulatory networks consisting of Transcription Factors (TFs) and cofactors proteins. Thus, a multitude of combination between TF and cofactors will be set up to regulate the transcription in a precise spatiotemporal manner. The evolutionary conserved class of Hox TFs perfectly illustrates how a restricted number of TFs is able to promote diverse transcriptional programs. Hox proteins are involved in the specification of body forms and organs in animals. Despite this notorious architectural role, their operating mode remains controversial: they recognize similar DNA-binding sites in vitro, in sharp contrast with their specific functions in vivo. Thus, Hox proteins are likely acting with cofactors in vivo, and their identification was the core of my post-doctoral work. Notably, it revealed that mRNA-processing related proteins could constitute an important class of Hox cofactors. Thus, Hox specificity could also rely on mRNA-processing regulation, providing insightful molecular entry points to understand Hox function in development and disease. My research project aims at elucidating this novel facet of Hox activity. I propose two complementary aims developed in two model systems in order to decipher the molecular and functional impact of Hox-dependent mRNA processing regulation. I will decipher how interactions with splicing factors impact on the Hox functions in vivo in Drosophila embryos. Moreover, I will enlarge the cooperative role of HOX and splicing factors by performing large-scale interaction-screens of several human HOX and 2000 RNA-regulatory proteins in various normal and pathological cell contexts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Evaluation and comparison of methods for estimating uncertainty in harvesting fish from natural populations.' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

To investigate the comparative reliability and consistency of some recent approaches for estimating the uncertainty attached to alternative actions for harvesting fish from natural populations, and identify those quantities of interest to management for which uncertainty can be quantified robustly. These new methods have been developed independently by workers in various countries and have not yet been subjected to comparative studies.In response to requests from managers for advice in the form ' What is the probability that a (specified) undesirable event will occur for a range of alternate actions ?', participating scientists have been developing methods for calculating the uncertainty attached to the estimates of stock parameters and of estimates of markers of undesirable conditions : biomass, fishing mortality and reference points, both in historic analyses and also in the future under various exploitation scenarios.This concerted action will coordinate some of the work currently underway by participants that is aimed at identifying what features of the methods for calculating uncertainty that are most important in determining the views of risk that are presented to managers by scientists. Recently developed methods will be subject to the comparative evaluation under this concerted action are listed in the following section. They will subsequently be referred to as the candidate methods" The purpose of the present project is to investigate whether advice currently being provided for fisheries management purposes by different workers using different methods is highly dependent on the choice of method and baseline assumptions used. If broadly similar estimates of uncertainty for some or most parameters are returned by all of the methods proposed, this would reinforce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Neuro-vascular communication in the neural tube during development' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Despite the critical importance of a precisely formed vascular network within the central nervous system (CNS), little is known about the molecular mechanisms that specifically control CNS vascularization. While other embryonic tissues undergo primary vascularization, the CNS becomes secondarily vascularized by sprouting angiogenesis from a previously formed vascular plexus. Angiogenesis within the CNS seems to require a different code of angiogenic signals compared to other organs, as surprisingly newly formed blood vessels avoid CNS regions where the pro-angiogenic factor VEGF is expressed. Still, angiogenesis within the developing neural tube (NT) follows a highly stereotypic pattern with blood vessels sprouting always at the same locations, following the same paths and avoiding specific regions.The goal of this project is to elucidate the cellular and molecular mechanisms that control this specialized two-step CNS vascularization.The originality and innovative character of this proposal relates to the hypothesis that in contrast to primary vascularization, which happens in response to conventional angiogenic signals, NT vascularization occurs by an orchestration of neuronal-derived signals, guiding vessels into the developing CNS, thereby assuring synchrony and adaptation to the specialized CNS tissue.Two research tracks are proposed:1: Identification of the neuronal cell populations that communicate with blood vessels during NT vascularization2: Identification and functional characterization of the molecular players controlling vascular patterning within the NTBoth tracks are designed to follow a multidisciplinary approach combining cutting edge technology in in vitro cell and 3D tissue culture, time-lapse microscopy, transcriptomics, proteomics and mouse genetics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Transnational access to major research infrastructure of wl | delft hydraulics' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Description:WL | Delft Hydraulics' experimental facilities are among the largest and best equipped in the world. They permit projects ranging from fundamental research on hydrodynamics and morphology in rivers, estuaries, coastal zones and seas to applied research on breakwaters, components of offshore platforms, pipelines and dredging equipment. Access is provided to the following unique experimental facilities:- The 130 m long Tidal flume, which can be considered as a schematised estuary. Tide, fresh water discharge, salinity, silt and oxygen concentration can be controlled at its boundaries. Both a tidal flow and wind waves can be generated;- The Rotating annular flume and complementary facilities are well suited to carry out detailed studies on the various processes which cohesive sediments undergo in fresh and salty waters, including the direct measurement of bottom shear stress;- The Oscillating water tunnel, which can be used to investigate the influence of oscillatory flow on the behaviour of bed material on scale 1:1. Tests can be performed with either random or periodic wave conditions, as well as combined flow and wave action;- The wave paddle of the 230 m long, 5 m wide and 7 m deep Delta Flume (Wave flume for large-scale testing) can generate regular or irregular waves up to a height of 2.5 m. The flume can be used for large scale experiments reproducing hydrodynamic loading, interaction with small and large bodies and sediment transport;- The 32 m wide and 45 m long Multi-directional wave basin is equipped with a 26 m wide wave paddle allowing the generation of swell and short-crested waves propagating at any direction within ± 45(0) and at the same time reproducing directional spreading;- The 55 m long, 1 m wide and 1.2 m deep Glass-wall wave flume has a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Plasmodium Exploitation of Liver-specific Methionine Metabolism' (PoEMM) under Horizon Europe.

assistant: **Objectives**

Malaria remains the most serious parasitic infectious disease, killing one child every two minutes. Plasmodium infection starts when the female Anopheles mosquito injects sporozoites into the skin of the vertebrate host. All Plasmodium species go through a phase of replication inside nucleated cells prior to infecting red blood cells and causing malaria, however, only mammalian-infectious parasites target the liver and replicate inside hepatocytes at an extraordinary rate to generate tens of thousands of erythrocyte-infectious merozoites. Avian and reptile malaria parasites, in contrast, infect macrophages near the bite site and differentiate into only dozens of erythrocyte-infectious merozoites. The reason behind the high replication rate achieved by mammalian-infectious parasites inside hepatocytes, key to guarantee the establishment of infection by overcoming the bottleneck of malaria transmission caused by a low sporozoite inoculum, remains utterly unexplored. The hypothesizes of this proposal is that the explanation for this lies in the uniqueness of the mammalian hepatic methionine metabolism bestowed by the mammalian liver-specific methionine adenosyltransferase (MAT1) enzyme and its capacity for generating unlimited amounts of S-adenosylmethionine. In agreement with this hypothesis, preliminary data show that Plasmodium’s high replication rate inside hepatocytes relies on the host liver-specific MAT1. By using a combination of genetic, cellular and molecular approaches I will decipher how the liver-specific methionine metabolism present in hepatocytes is hijacked and used by the parasite to achieve such high replication rates and assess the competence of the liver-specific MAT1 in sustaining Plasmodium replication. This proposal has the potential to establish a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Towards Carbon-Neutral Composite Crashworthiness' under Horizon 2020.

assistant: **Concept**

The transport sector is currently facing global economic uncertainty, tough market competition, stringent EU emission and efficiency targets, increased vehicle occupant safety requirements, and pollution and safety scandals which have damaged its reputation. These factors require engineers to increasingly adopt the use of composite materials, to come up with cheaper, safer, and more environmentally friendly solutions. However, even if these materials enable the production of light energy-efficient vehicles, most carbon fibre composites are expensive, and thus the majority of their current applications are limited to the aerospace and motorsport industries. Furthermore, conventional composites have a high manufacturing carbon footprint, and they are typically non-recyclable at the end of life of the components.  Natural fibre composites (NFCs) are now being used in the automotive industry, as a cheaper and more environmentally friendly option to conventional carbon fibre composites, albeit limited to non-safety critical components, due to their poorer mechanical performance. The TEMPEST research programme aims to explore the possibility of using a novel NFC material offering improved mechanical performance (developed by partner organisation Bcomp) in safety-critical structural components. Furthermore, by collaborating with McLaren Racing, who have been developing composite crash structures for over two decades, the project aims to advance on the current state-of-the-art in the fields of experimental and numerical crashworthiness, all the while trying to reduce the carbon footprint of such structures. The project also aims to enhance the creative and innovative potential of the researcher, wishing to diversify his competences to include sustainable composite material deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Monolithic Diamond Raman Laser (MonoDial)' (MonoDial) under Horizon 2020.

assistant: **Objectives**

This proof of concept proposal will build on an innovative monolithic diamond Raman laser, with near quantum limitedefficiency demonstrated during the ERC starting grant DiaL. A range of important applications will be scoped and the technology tailored to meet the most promising market demands. The result will be a platform approach to compact laser design taking existing Nd:YAG-based lasers to wavelengths with a strong applications pull that cannot be met with current technology. This will extend the product lines and market penetration of EU laser companies.This programme has two complementary tracks: working with specialists, we will identify the market pull and the required laser specifications; in parallel, we will engineer the science developed within DiaL to address these needs in a compact, robust and cost-effective way.