RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Asymptotic approach to spatial and dynamical organizations' (ADORA).

assistant: **Concept**

The understanding of spatial, social and dynamical organization of large numbers of agents is presently a fundamental issue in modern science. ADORA focuses on problems motivated by biology because, more than anywhere else, access to precise and many data has opened the route to novel and complex biomathematical models. The problems we address are written in terms of  nonlinear partial differential equations. The flux-limited Keller-Segel system, the integrate-and-fire Fokker-Planck equation, kinetic equations with internal state, nonlocal parabolic equations and constrained Hamilton-Jacobi equations are among examples of  the equations under investigation. The role of mathematics is not only to understand the analytical structure of these new problems, but it is also to explain the qualitative behavior of solutions and to quantify their properties. The challenge arises here because these  goals should be achieved  through a hierarchy of scales. Indeed, the problems under consideration share the common feature that the large scale behavior cannot be understood precisely without access to a hierarchy of finer scales, down to the individual behavior and sometimes its molecular determinants. Major difficulties arise because the numerous scales present in these equations have to be discovered and  singularities appear in the asymptotic process which yields deep compactness obstructions. Our vision is that the complexity inherent to models of biology can be enlightened by mathematical analysis and a classification of the possible asymptotic regimes. However an enormous effort is needed to uncover the equations intimate mathematical structures, and bring them at the level of conceptual understanding they deserve being given the applications motivating these questions which ra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'The development of a new more efficient and safer portable traffic optimisation system for EU ports'.

assistant: **Objectives**

Maritime industries in the EU had a turnover of 159 bn and employed 1545000 people in 1997. They added value of 70 bn 1 of GDP and contributed 23 bn 33 of VA to EU funds. The project will increase the competitiveness of European industrial ports by increasing port throughput by 10. It will achieve this by improving the accuracy of calculation of under keel clearance UKC from 50 cm to 10 cm enabling more ships to pass through the ports during a tide. The project will also increase real time ship movement forecasting and position accuracy this will reduce accidents and groundings in narrow waters which will improve safety and increase port throughput. It will introduce a new sensor that will provide very accurate real time ship movement forecasting in the case of GPS system blackout.The market for OPTIPORT could be very large in this growing and increasingly competitive industry Our provisional analysis of the target market size indicates that within Rotterdam port there are potentially 1 000 users for 300 OPTIPORT systems A provisional estimation of demand is 15 000 European systems and 20 000 in North America. At a target selling price of 25 000 this gives a market value of 375m in Europe and 500m in North America. The proposed project will create international export opportunities for those involved in the manufacture of this new ship navigation technology help to protect the sector they serve from globalisation effects and increase their competitiveness through the following OPTIPORT key product features Increased port throughput Improved ship safety during port entry Low cost...
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'The i-Thymus: wielding the potential of gene therapy, cell therapy and induced pluripotent stem cells for the regeneration of the thymus and the adaptive immune system'.

assistant: **Innovation**

Each year, >250 babies are born without a thymus. These babies have a life expectancy of 2-3 years. The only cure is transplantation of thymus tissue, but this has a 30% mortality rate and costs almost >€2.5M. We developed i-Thymus, a revolutionary cure based on the patient’s own cells leveraging innovative gene therapy to generate thymus organoids that can be implanted minimally invasively in the patient (Fig. 1). We have already shown this works in functional proof of concept in vivo. With this EIC Accelerator, we will finalise development to enter the clinic for a Phase I/II trial, to enter the EU market with a pharma partner by 2028. After rapid market entry with ODD for complete DiGeorge syndrome, we will leverage this clinical success and our first revenues to develop i-Thymus for unmet needs of hundreds of thousands of other patients, starting with AML patients who have lost thymus function after high-dose chemotherapy for stem cell transplantation.


**Keywords:** Advanced Therapy Medicinal Product,Cell therapy,Regenerative medicine,Organoid technology,Induced pluripotent stem cells,Thymus,Gene therapy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Boosting conversations to disrupt horticulture trading' (Consentio) under Horizon 2020.

assistant: **Objectives**

More than 75% of commercial transactions between companies in the F&V (fruits and vegetables) sector are initiated with an instant messaging conversation that is followed by a long process with many interactions on different channels (emails, calls, etc.). Easing these interactions will improve the efficiency supply chain and will have a high economic impact. This impact is strengthened in the F&V sector because it deals with perishable products and the amount of goods lost along the distribution chain and retailers due to degradation and expiring “best-before-dates” is moving further along, 7.5% Consentio is a digital application (App & Desktop) with a conversational approach that mechanizes a large share of selling/buying flows in the F&V market. It strengthens the existing relationships between stakeholders and increases the global efficiency of the sector. New commercial opportunities could stem out as well.Although there are some marketplaces oriented to the horticulture field, our main difference with respect them is that we target the whole market taking advantage the existing relationships that at present account for the 90% of the volume of activity. We are also working to integrate conversations with legacy systems to enable an end-to-end management of transactions. Our team is innovative and well balance with high experience in setting successful start-ups with technological foundations and with demonstrated know-how in technology and management fields. We have also tested an MVP (minimum viable product) in several countries with potential customers that have showed a high interest in acquiring our application. We have obtained 850K Euros in venture capital funding, but we need 1.2 M Euros to have a full version with capability to disrupt the horticulture sup
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nonlinear metasurfaces with 2D materials: Exploring their properties utilizing quasinormal modes' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The regular rising demand for faster wireless communication (i.e., larger spectral bandwidths) was anomalously boosted recently due to the change on working habits of the Europeans who nowadays more and more work from home or become digital nomads. Optical metasurfaces offer this required high bandwidth combining it with easy fabrication, flexibility, and advanced functionality, rendering them a potential candidate to encounter this demand in wireless optical communications. Despite their large application span (wavefront manipulation, beam steering, perfect absorption), the design of optical metasurfaces is sometimes counter-intuitive and computationally cumbersome, especially when more advanced functionalities are targeted (nonlinear/all-optical control), typically realized by resorting to contemporary material options such as the 2D materials platform. QUARTE aims to present a coherent modal computational framework for the analysis and design of linear and, importantly, nonlinear metasurfaces realized with 2D materials, demonstrating advanced functionalities and all-optical control. The proposed modal framework, based on the concept of quasinormal modes (i.e., the natural modes of leaky and lossy cavities), will be capable of efficiently handling periodic systems (metasurfaces, gratings) consisting of 2D materials and possessing linear and, importantly, nonlinear responses and functionalities. Furthermore, as a modal technique, the proposed approach is capable of revealing the true physics that govern light-matter interaction, especially in the more obscure nonlinear regime, allowing for fast, efficient, and optimal designs with physical intuition and understanding of the involved physics and interactions. The realization of QUARTE research targets will be performed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'EXposome Powered tools for healthy living  in urbAN SEttings'.

assistant: **Objectives**

By 2030 more than 80% of Europe’s population will live and interact with a complex urban environment, consisting of a mixture of social and environmental factors. These factors include: where we live and work, where and what we eat, our social network, and what chemical substances we are exposed to. Individually or collectively these factors, known as the Urban Exposome, have an often modifiable impact on our health and provide important targets to improve population health. By studying the impact of the Urban Exposome on the major contributors to Europe’s burden of disease: Cardio-Metabolic and Pulmonary Disease, EXPANSE will address one of the most pertinent questions for urban planners, policy makers, and European citizens: “How to maximize one’s health in a modern urban environment?”.EXPANSE will take the next step in Exposome research by: 1) bringing together the Exposome and health data of more than 55 million Europeans in administrative cohorts, in-depth Exposome, phenotype, and OMICs information for more than 2 million Europeans, and personalized Exposome assessment for 4,000 individuals living in five “Urban Labs”; 2) applying a novel approach to use ultra-high-resolution mass-spectrometry to agnostically screen for exogenous chemicals in 10,000 blood samples; 3) studying the evolution of the Exposome and health through the life-course via both (matured) birth and adult cohorts; and 4) evaluating the impact of changes in the Urban Exposome on the burden of Cardio-Metabolic and Pulmonary Disease.EXPANSE will translate its insights and innovations into research and dissemination tools that will be openly accessible via the EXPANSE toolbox. By applying innovative ethics-by-design throughout the project, the social and ethical acceptability of these tools will be s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Second Order Perovskite Memristor Chip for Neuromorphic Computing' in the context of a Horizon Europe call.

assistant: **Objectives**

The rising demand for complex computing in artificial intelligence (AI), machine learning, and data processing, presents a major energy challenge. In this regard, traditional silicon-based computing systems, based on the Von Neumann architecture, are becoming increasingly inefficient in terms of energy consumption. This makes it inevitable to find alternative solutions for developing noble energy efficient computing devices. Neuromorphic device which emulates the brain’s neural activities, offers a path to low energy computation. However, state-of-the-art neuromorphic devices mimic only first-order synaptic behavior, such as simple time-dependent plasticity. While the advancements are impressive, but these devices lack the ability to emulate more complex higher-order synaptic functions, such as multi-synaptic plasticity or history-dependent memory. These advanced functions are crucial for handling intricate tasks for example, decision-making, pattern recognition, and reasoning in AI. SPECIFIC aims to overcome this barrier by leveraging the properties of vacancy-ordered perovskites, which will positively contribute to the development of next-generation high-order memristors. To do so, we will exploit the tunability of perovskite materials to modulate defects, transport, and interfaces, which will be tailored to achieve second-order logic in potentially scalable bio-realistic devices. SPECIFIC seeks to establish guidelines for designing second-order memristors, integrating timing- and rate-based correlations for advanced neuromorphic computing tasks. These goals align with the European Green Deal’s goal of reducing carbon emissions, as the energy-efficient devices developed will contribute to the EU’s target of net-zero emissions by 2050. Additionally, this cutting-edge p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Direct implication of the Calcium Sensing Receptor in Vascular Calcifiction and Atherosclerosis in Chronic Kidney Disease' (AtheroCaSR), addressing dissemination and exploitation.

assistant: **Impact**

The principal cause of death in chronic kidney disease (CKD) patients is cardiovascular disease (CVD). Current therapies to treat vascular calcification (VC) and atherosclerosis, which mainly target mineralization and hyperlipidaemia, are not fully effective and have considerable limitations; therefore, additional mechanisms must be investigated. In this respect, hyperphosphatemia is associated with CVD and mortality in CKD patients. Recently, it has been demonstrated that phosphate inhibits Calcium Sensing Receptor (CaSR) signalling, which arise the hypothesis of a direct CaSR implication in vascular (patho)-physiology. Moreover, CaSR promotes opposed effects in vascular smooth muscle cells (VSMC) and osteoblast, preventing calcification in VSMC while increasing mineralization in osteoblast. Given the accumulative evidences that CaSR may exert protective vascular effects, the aim of the AtheroCaSR project is to study whether CaSR activation prevents vascular disorders while preserving bone health. To address this aim, the effects of CaSR modulation will be tested in vitro on VSMC calcification and osteoblastt differentiation under CKD conditions. Then, the effects of the specific CaSR deletion in VSMC will be studied on VC and atherosclerosis in mice with renal insufficiency using novel novel Next-Generation Sequencing for analysis of single cell transcriptome and translational efficiency, with focus on vascular lesions and mineral metabolism. In addition, whether calcimimetics prevent VC and atherosclerosis will be investigated in mice with reduced renal function. Finally, if CaSR modulation directly reduces VSMC microcalcification and atheromatous plaque will be analysed in a cohort of CKD patients treated with calcimimetics. The results from this ambitious study wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'AI-driven discovery broad-spectrum antivirals targeting Nucleocytoviricota factories via phase separation modulation' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The phylum Nucleocytoviricota includes (re-)emerging dsDNA viruses of major concern, such as monkeypox virus (mpox) and African swine fever virus (ASFV). Despite their economic and public health impact, no formally approved antivirals exist for these pathogens. Viral factories (membrane-less organelles essential for replication) are highly conserved across Nucleocytoviricota, presenting an attractive and untapped target for antiviral intervention.PSDisrupt builds on findings from the ERC-funded ViDaMa project, which identified scaffold proteins governing phase separation in viral factories. These proteins share a conserved ""molecular grammar"" essential for condensate formation. Disrupting this process is expected to broadly inhibit viral replication while minimizing the development of resistance.This PoC project will design phase-separation grammar-targeting antivirals using AI-driven pipelines. Deep learning models will enable the screening of ultra-large chemical spaces to identify: (i) broad-spectrum inhibitors targeting conserved scaffold proteins across Nucleocytoviricota, and/or (ii) virus-specific antivirals for mpox and ASFV.PSDisrupt’s translational goal is to design and advance lead compounds into preclinical validation and assess their commercial potential. We will:-Discover and design drugs by leveraging high throughput screens and deep learning-based algorithms.-Perform biophysical and cellular assays to validate compound efficacy.-Establish IP protection for novel inhibitors.-Engage with pharmaceutical and biotech partners for licensing and further development.By bridging virology and AI-driven drug design, PSDisrupt pioneers a novel antiviral strategy with broad applications beyond infectious diseases. The AI framework could be adapted to target phase s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nanophotonics by Nanocrystals, from integration to single photon operation' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Phonsi is a research and training program on the development of nanophotonic devices by means of colloidal nanocrystals. Working at the cross-roads of nanomaterials and nanophotonics, it brings together multinational and start-up companies with universities and research institutes around a research programme combining the synthesis and analysis of quantum dots (QDs) with the formation of QD-based nanophotonic devices for emitting and detecting light down to the single photon level. The consortium contains complementary, world-leading expertise that crosses research disciplines, attitudes and methodologies such as chemistry/physics/engineering, synthesis/analysis/simulation, lab-scale/industrial scale and scientific discoveries/research valorization. At each level, the project is driven by highly challenging and timely research goals, which are translated into well-defined, collaborative training-through-research projects. These train ESRs in different disciplines, give them the opportunity to work with high end scientific instrumentation and expose them to both academic and non-academic research environments. The research projects are complemented by a varied set of network-wide training events that rely on the active involvement of the trainees and stimulate their self-learning capabilities. Local specialist training addresses complementary skills, which trainees will put into practice by contributing to the training events and dedicated public engagement activities. The deep involvement of non-academic partners, including two recently established spin-offs, creates a vibrant research and training environment that fosters a spirit of research valorization. In this way, the program will enable Europe to train ESRs with the multidisciplinary skills in nanomaterials, nano