RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Addressable Molecular Node Assembly - a Generic Platform of Nano-scale Functionalised Surfaces Based on a Digitally Addressable Molecular Grid' (AMNA).

assistant: **Concept**

The goal is a nano-technology platform based on a 100 nm size grid of addressable molecular building blocks, a novel bottom-up modular approach to place functional groups at defined positions in space with sub-nm precision. An almost complete freedom of ch oice, for grid assembly as well as for positioning of functional groups is based on a digital" code for molecular recognition. The project involves very demanding synthetic and physico-chemical tasks: on the other hand, if successful the reward is enormou s as it can provide a basis for a range of forceful nanotechnological applications (it might even become the basis for future nanotechnology!). High structural fidelity and convenient assembly rates are achieved using DNA base-pair recognition and stacking into rigid double-helical structures. Each node has typically three oligonucleotide strands and a moiety for attachment of either a functional group or a lipid anchoring group, so that a group of six nodes are connected into a hexagon (energetically favou rable) providing a planar network of hexagons. Further kinetic robustness may be achieved. The partners represent the ultimate expertise in Europe in synthetic and supramolecular chemistry and in biophysical, colloidal and photophysical chemistry, needed f or the joint venture: 1. Synthetic strategy for node building blocks. 2. Tuning interactions and reaction rates to ascertain correct assembly into grid attached to lipid support. 3. Positioning of functional groups. 4. Analytical tools to follow assembly a nd verify structures. From here various applied projects will take over, attaching interesting functional groups at pre-determined positions on the grid map, and supramolecular structures extending perpendicular to the grid surface, into the 3rd dimension. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fundamental Aspects of Surface Science' (1998-2002).

assistant: **Innovation**

The main objective of this Euroconference is to contribute to close this gap by bringing together leading scientists working in heterogeneous catalysis from both theory and experiment whose common goal is a fundamental understanding of molecular mechanism in catalytic. Consequently, the first meeting will deal with a wide range of topics all related to catalysis, from the models of surface science, to catalysis by different materials (oxides, sulfides, metals, bimetallic catalysts, zeolites), covering various catalytic processes (homogeneous catalysis, electrocatalysis, supported catalysis and their models, promotion effects in catalysis) as well as theory of catalysis, addressing , among other aspects, kinetics problems and activation barriers.Metals as heterogeneous catalysts are in most cases applied in the form of highly dispersed supported metal particles. These particles are usually deposited on inert" oxides, MgO, A1(2),O(3),SiO(2), or impregnated in the pores of porous materials, like zeolites. Furthermore, oxides are themselves active catalysts. In recent years important activities in surface science have been directed towards the characterisation of oxide surfaces. The second conference of this series is intended to cover the most recent aspects of experimental and theoretical research on oxides surfaces, thin oxide films, metal-oxide interfaces, etc. with particular emphasis on supported metal species.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00168-1.pdf"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Unmanned Airborne Water Observing System' (UAWOS), addressing dissemination and exploitation.

assistant: **Impact**

Background: High-resolution monitoring of rivers is important because rivers are severely affected by climate change and frequency/magnitude of extreme events are changing fast. Advanced in-situ monitoring technologies have to be combined with satellite earth observation (EO) to obtain accurate, reliable and spatio-temporally resolved information for effective decision support, risk assessment, climate change adaptation investment analysis, and operational forecasting/surveillance.Problem being addressed: Traditional hydrometric monitoring of rivers is in-situ and station-based. In-situ monitoring networks lack spatial resolution, have been declining in many regions, and data accessibility is increasingly restricted because of growing conflicts between countries over water resources allocation. In order to solve this problem, hydrometric monitoring using satellite earth observation has to be combined with drone-borne hydrometric monitoring technology for validation, deployment in remote and inaccessible regions, and to enable reliable and accurate river discharge estimation.Our solution: UAWOS develops a drone-borne water observation system providing key hydrometric variables (bathymetry, velocimetry, water surface elevation) at high spatial resolution/coverage, and data-based products/services supporting management and decision making. UAWOS integrates airborne data streams with Copernicus water bodies and water level services for cross validation and to estimate river discharge from satellite EO data.Impact: We expect that UAWOS hydrometric monitoring solutions will be factor 2-3 cheaper compared to traditional in-situ surveying. UAWOS technology will provide very high spatial resolution with accuracy on par with traditional in-situ monitoring. The technology will sup
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Comprehending Human Action using Social Networks', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

This proposal consists of three interconnected projects that study how social networks shape the behavior of 1) scientists, 2) politicians, and 3) citizens by using the structure of networks for identification.The first project investigates how social media networks shape knowledge production in academia. Through a comprehensive dataset of economists and their Twitter activity, the project provides insights into the information acquisition process of scientists and how scientists’ networks impact the direction of science. The project will examine the causal effect of social media usage on research output, collaboration, citation patterns, and careers. Moreover, the project will highlight inefficiencies in the scientific process that arise through scientific fads and herd behavior.The second project will generate some of the first large-scale empirical analyses of the role of congressional staffers in the policy-making process. Based on comprehensive data on congressional staffers, their networks, and the activities of congress members, the project will generate pathbreaking insights into the impact of staffers on congressional voting behavior as well as policy priorities. The project will isolate the effect of staffers using a network-based identification strategy that leverages the educational ties of staffers. In this way, the research project will break new ground in the field of political economy by opening the black box of the policy-making process.The third project focuses on the political effects of social media and the effectiveness of algorithmic interventions by investigating the impact of sharing limits on the social media platform WhatsApp. The project will analyze how this change to information flows on a network affects conflict events, believes, and elect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Amyloid-ß oligomerization: synapse disruption and neurotoxicity mechanisms' in the context of a Sixth Framework call.

assistant: **Objectives**

The amyloid beta peptide (A-beta) plays a central role in the pathogenesis of Alzheimers disease but it remains unclear how exactly this peptide impacts on neuronal viability and cognitive functions in AD patients.More and more it is believed that synaptic dysfunction and loss caused by small soluble A-beta oligomers, but not by mature fibrils deposited in the plaques, is the first sign of neurodegeneration in AD.The A beta sequence contains two boxes that may regulate the aggregation process of the peptide and therefore the first objective of the proposed project is to modify by mutagenesis these aggregation-related A-beta boxes and clarifying the connection between aggregation and neurotoxic properties of the A-beta peptide.In addition, we will set up a series of robust and reliable assays to measure synaptotoxicity caused by the A-beta oligomers in primary hippocampal neuronal cultures and in mouse models. To that aim we will in collaboration with the institute for microelectronics (IMEC) develop the Neuro-Electronic hybrid sys tem or Artificial SynApse, the neuro-electronic device that allows measuring changes in the synapse in a high throughput mode.This neuro-electronic device will make it possible to sense electrical and biochemical changes of neurons in real time upon addition of toxic A-beta to a neuronal network of hippocampal neurons. Consequently, the neuro-electronic device will allow in the long run screening for compounds that interfere with amyloid oligomers-mediated neurotoxicity.In conclusion, it is our objective to contribute to the understanding of the pathological process causing Alzheimers Disease and to development of a cure for this devastating disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Ultrasonic assessment of osteoporosis in cancellous bone'.

assistant: **Innovation**

Osteoporosis is metabolic bone disease leading to be enhanced bone fragility and as a consequence increases in fracture risk. The socio-economic burden of the disease has triggered considerable effort to develop new and cost-effective methods for early detect ion, prevention as well as treatment. Radiation free quantitative ultrasound (QUS) offers the advantage of relatively low cost and portability compared to X-ray densitometry, and is currently considered as the most promising tool for assessment of bone quality. Ultrasonic waves have the potential to assess both mechanical and structural properties of bone as well as their deterioration due to osteoporosis. However, till now, mainly because of the lack of proper theoretical model, it is difficult to use available advanced signal processing techniques to extract of mechano-structural characteristics of cancellous bone.The scientific aim of the project is to develop and validate theoretical model of propagation of ultrasonic waves in cancellous bone useful in solving direct or inverse problem toward quality assessment of bone. This goal will be achieved by analysis of the data obtained from: synchrotron microtomography (SR-µCT); combined transmission/reflection ultrasonic studies coupled with innovative compute r simulations of wave propagation in real 3D trabecular bone structures reconstructed from SR-µCT and analysis of existing/developed models of propagation of elastic waves in inhomogeneous materials. If successful, in a short-term perspective, it will be possible commercially disseminate the developed model-based methodology into clinical measurements in new versions of QUS devices. Realization of the scientific project will contribute to the fellow professional maturity toward the preparation of habilitation t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The World’s Only Bioprosthetic Auto-regulated Artificial Heart: From Total Artificial Heart (TAH) to Physiologic Heart Replacement Therapy (PHRT)' (TAH).

assistant: **Concept**

At Carmat we have designed and developed Aeson®, the world’s most advanced total artificial heart (TAH), aiming to fulfill an unmet medical need by providing a credible therapeutic alternative to heart transplants for people suffering from end-stage biventricular heart failure. Aeson® is an active implantable medical device intended to replace the ventricles of the native heart in patients suffering from advanced heart failure. The device is electro-hydraulically driven with a shape close to that of a human heart. Once the Aeson® is powered, it mimics the action of a normal heart, providing mechanical circulatory support and restoring normal blood flow through the body.Aeson® differs from other existing artificial hearts (or TAH – total artificial hearts) in its unique combination of three features: pulsatility, autoregulation and hemocompatibility. With Aeson®, Carmat is creating a new therapeutic class of “physiologic heart replacement therapy” (PHRT).


**Keywords:** Bridge to transplant (BTT),Destination therapy (DT),Pulsatility,Biventricular assist device,Surgery,Heart,Heart Failure,Mechanical Assist Devices,Hemocompatibility,Bio prosthetic,Haematology,Total artificial heart,Cardiology,Biophysics,Bioengineering,Biomedical engineering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Engineering an integrated platform for generation of human blood stem cells from pluripotent sources' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Life-saving blood cell replacement depends on voluntary donors. Availability is a challenge for specific groups, and 25% of patients needing blood stem cell transplants lack a compatible donor. The ideal alternative is clinical-scale production of Haematopoietic Stem Cells (HSC) from laboratory-maintained tissue-compatible sources, to provide an off-the-shelf source of blood cells. HSC are generated in the aorta/gonad/mesonephros region of the embryo, expand in the foetal liver, and are maintained in the bone marrow of adults. Current attempts to generate HSC in vitro do not consider the changing cellular, chemical, and physical characteristics of the different environments met by HSC in vivo from embryo to adult, and have been unable to reliably produce functional HSC. MakingBlood aims to establish a proof-of-concept platform for robust generation of human HSC from pluripotent stem cells by developing a self-organising gastruloid model of embryonic HSC generation without genetic manipulation, and successively recapitulating the natural foetal and adult HSC development environments. MakingBlood brings together an expert in HSC embryonic development, a national blood bank research director with expertise in adult HSC, an expert in molecular regulation of cell fate choices, and a bioengineer with expertise in mechanical and chemical integration for tissue production to deliver this breakthrough platform. By using state-of-the-art technology and multidisciplinary approaches, we will systematically detangle cellular, chemical, and physical properties of natural HSC generation, amplification and maintenance microenvironments, and iteratively identify essential elements that enable and promote HSC function. We will integrate key elements into modular scalable engineered niche
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'INTEGRATED PLATFORM FOR INTELLIGENT INDOOR AIR QUALITY AUDIT MANAGEMENT' (AIRLOG), addressing dissemination and exploitation.

assistant: **Impact**

While ambient air pollution is being successfully monitored throughout the EU, the situation for indoor air pollution is not nearly as positive. This is of particular concern, as a much wider range of air pollutants are found at high levels indoors than outdoors. Indoor air quality is a major concern to businesses, building managers, tenants, and employees because it can impact the health, comfort, well being, and productivity of building occupants, as most Europeans spend up to 90% of their time indoors and many spend most of their working hours in an office environment. Studies conducted by the U.S. Environmental Protection Agency (EPA) and others show that indoor environments sometimes can have levels of pollutants that are actually higher than levels found outside. In spite of the obvious need to better control and manage the quality of indoor air, no European legislation or norm currently defines indoor air quality auditng and management systems, leaving it to the member states' responsibility to define air quality targets and risk levels, certification procedures and audit management processes. AIRLOG proposes a web-based Indoor Air Quality (IAQ) Audit Management platform that will save specialized SMEs up to 40% of the cost of performing audits, helping auditors improve their audits and clients better understand the IAQ process. AIRLOG’s Decision Support System will learn from past experiences and propose the most effective Best Practice mitigation actions to ultimately improve IAQ control and healthier conditions in EU buildings. The link between sustainable building design, energy-efficient management and green procurement will be actively fostered by AIRLOG, through the development of a unique knowlegde base at EU level on successful indoor air management prac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dual Citizenship Recognition and Equal rights in Germany: Construction of a (Trans)national Form of Citizenship in 21st Century Europe' (Trans).

assistant: **Innovation**

Migration, E-U integration and equalisation of rights between men and women as to maintaining and passing nationality have led to the increase of dual citizenship, which has become a main political issue in many European countries and a key topic to understand the transformation of civil societies.Built on political anthropology of the State, the project focuses on nowadays’ Germany to see how issues about the recognition of this status can be understood within the reconfiguration of EU-immigration policies. Through an ethnographic approach, it studies both dual citizenship politics and experiences to build a multi-dimensional model of nation and immigration issues in the European context. (1) It examines the moments of problematisation of a dual citizenship issue in Germany, since 1989 until the last controversy about its full recognition in spring 2013 in the light of historical and political transformation of society and the democratic configuration of German politics.  (2) It analyses the discursive strategies and collective actions that aim at the full recognition of dual citizenship. (3) It studies the legal and administrative practices that frame the way in which German State tolerates dual citizenship. (4) It explores, through personal narratives, the everyday experience of German dual citizens with different backgrounds to show how gender, race and social class guide the uses of dual citizenship. With a comparative approach to differentiated migration experiences, it figures out how this status may weave into patterns of everyday life.The project fills a void as it proposes an new approach to dual citizenship at the intersection between political anthropology of the State and ethnography of everyday life.Opening perspectives to Germany is an asset for my career