RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Interactively connecting our polymer production design'.

assistant: **Innovation**

A challenge in the polymer industry is the design of molecular and morphological properties along the whole production chain, minimizing energy consumption and product heterogeneity, and ensuring recyclability. Ideally, we need to track the compositional/topological variations and interactions of individual species during (i) synthesis, hence, the polymer reaction engineering (PRE) stage; and (ii) downstream final material shaping, hence, the polymer processing (PP) stage (e.g. (reactive) extrusion).Today, the connection between the PRE and PP stage is weak and monodirectional, with only average, not distributed, ballpark PRE characteristics inputted in PP optimization. Both stages although share common bottlenecks such as micro-scale viscosity changes, meso-scale mixing limitations, and macro-scale concentration/temperature gradients.POLY-DESIGN aims at next-generation polymer performance intensification and functionality design by a generic PRE-PP multi-scale modelling tool, tracking all changes at all length scales during synthesis and processing. This ambitious approach interactively connecting PRE and PP can tackle complex demanding products, and cost efficiently produced goods that will drive the commodity and high-tech polymer market.A validated PRE multi-scale modelling tool is applied to access all distributed PRE characteristics, uniquely for (i) linear and branched/crosslinked (co)polymers; (i) lab and commercial polymers; and (iii) pure polymers and their blends. The polymer (blend) viscoelasticity is calculated with a multi-scale PP modelling tool at any PP shear rate and temperature for any set of PRE characteristics. In this way, an industrial PP unit can be designed from the chemical to the material level and reversely thanks to a flexible PRE-PP connect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mechanical ventilation for radiotherapy' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

One of the greatest challenges for modern radiotherapy is ventilation causing motion of tumours and surrounding healthy structures.  Technically, modern radiation delivery systems enable in principle very accurate radiation targeting of the tumour and avoiding radiation damage to healthy tissue. However, to deliver sufficient dose to a continuously and irregularly moving tumour, it is necessary to irradiate the tumour with a large margin. Currently such a large margin means irradiating a volume of healthy tissue that is about equal to that of the tumour itself. The healthy tissue damage is itself problematic.  But it also prohibits further raising the radiation dose to the tumour to enhance the probability of tumour destruction and thus patient survival. I have invented the use of non-invasive mechanical ventilators to revolutionise radiotherapy delivery, by prolonging breath-hold duration beyond 5 minutes and by reducing and regularising breathing movements. I have demonstrated this works with breast cancer patients. To support its clinical adoption it is now necessary to train other staff to use mechanical ventilation, demonstrate it works with other cancer patient groups, measure the reductions in internal movement of tumours and healthy structures, show how these would produce superior treatment plans and that all this works in another European hospital. My career goal is for me to use the evidence derived from the fellowship to fund the introduction of non-invasive mechanical ventilators first back in our own department (Birmingham, UK), then for me to lead a multi-centre evaluation trial across Europe and finally to lead its introduction into radiotherapy practice throughout Europe.


**Keywords:** prolonged breath-holds, mechanical ventilation, radiotherapy, MRI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Predicting microbial death during heat treatments on foods' (BUGDEATH) under Fifth Framework.

assistant: **Objectives**

Food poisoning is increasing throughout the EU. Since most of the microbial contamination of foods is present on the surface of foods before they are processed, the elimination or substantial reduction of pathogens from the surface of red and poultry meat and fruit and salad vegetables would significantly reduce food poisoning. Recent decontamination investigations have not achieved the degree of microbial reduction that was predicted using existing microbial death kinetic models. Accurate models of microbial death on foods during surface pasteurisation processes would be of considerable help in the development of efficient thermal decontamination systems for meat, fruit and vegetables. The development of such systems would lead, in turn, to improved food safety and quality. This project will develop and verify such models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Exploiting the Nonlinear Fiber-Optical Channel' in the context of a Horizon 2020 call.

assistant: **Objectives**

The demand for bandwidth in optical fiber communication systems is increasing at a steady rate. In order to keep up with the demand, techniques to overcome the limit determined by the nonlinear nature of optical fiber transmission have attracted a lot of research attention.Recently, transmission using the nonlinear Fourier transform (NFT) was proposed as a promising technique to take advantage of fiber nonlinearities for data transmission. The technique uses signal states which are invariant to the fiber optical channel in certain system configurations. However, many challenges and open questions remain concerning NFT transmission in particular regarding suitable signal processing algorithms and coding strategies for such systems. It is currently unknown how NFT transmission performs with practical coded modulation and detection schemes and how its computational complexity and practical feasibility compares to other options for nonlinearity mitigation such as digital back-propagation. Furthermore, the impact of inter-channel nonlinearities and co-propagating wavelength channels has not yet been investigated. The only experimental demonstrations to date consider single-channel transmission.The project aims to address the aforementioned questions by first investigating coded modulation schemes for nonlinear channels based on existing commercial architectures. One of the key aspects is to gain insight in the signal statistics for the nonlinear channel and learn how to utilize this information for increased signal processing and decoding performance. Based on these results, the applicability and performance of coded modulation concepts for NFT transmission will be quantified for practical system scenarios. Furthermore, the impact of co-propagating WDM channels on coded NFT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Prevent Rheumatoid Arthritis in Practice' (PRACTICE).

assistant: **Innovation**

The idea is to develop vaccines and companion diagnostics for treatment of rheumatoid arthritis (RA). The idea is built on (i) knowledge that the immune systems harbors a capacity for specific reregulation of its actions, both in increasing its actions (e.g. existing vaccination against polio, measles etc.) and in decreasing its actions (“vaccinations” against autoimmune diseases, which has so far been executed successfully in animal models where enough is known about specificity for disease-inducing immunity); (ii) an insight that a major hurdle for development of “specific immunotherapy” (vaccination) in human autoimmune disease is a lack of enough understanding of the specificity of disease-inducing immune reactions in the human conditions; (iii) very significant progress that is currently being made within my ERC-funded project and in other groups concerning specificity of arthritis-inducing immunity in subsets of RA where these subsets are defined by the combined actions of genes, environment and immunity; most importantly, we have been able to define the specific structures (MHC classII-peptide complexes) that are recognized by potentially disease-inducing Tcells in RA. This has been a major lacking feature for the development of specific immunotherapies in this disease.We will use the ERC PoC funds to improve our understanding of the industry landscape and regulatory requirements, secure strategic collaborations, broaden and strengthen our patent portfolio, set-up a limited IPR based company set up and develop an attractive “investors package”. By the end of the period we will seek financing from private investors. Our team consists of the ERC grant holder (Lars Klareskog), a prominent animal arthritis experimentalist (Rikard Holmdahl), a prominent cell immunolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Untranslatable Modernity: Modern Literary Theory from Europe to Iran' (TRANSMODERN), addressing dissemination and exploitation.

assistant: **Impact**

It is widely accepted that the advent of modernist Persian literary theory, its transformation from traditional Persian rhetoric (balagha) into modern criticism (qeritiqa) in the mid-nineteenth century, has been driven by translation and adaptation of European literary critical norms. While the central role of translation in importing and transmitting critical norms has been emphasized in the studies of the evolution of modern Persian literary theory, these studies usually take translation for granted without noticing that a major part of this literary and critical modernity has been shaped around the challenges of untranslatability. TRANSMODERN will innovatively theorize the shaping of modern Persian literary criticism around untranslatability through a close study of a wide range of Persian publications in literary criticism, from 1860s to 2000s. This will permit an understanding of how European critical norms affected Iranian literary systems and how the adaptation of these norms to a radically different non-European poetics transforms the way we think about and experience the literary form. TRANSMODERN will deploy and combine methods of archival research, translation methodologies and comparative qualitative and quantitative analysis. The main outputs will be three peer-reviewed articles, a critical monograph and academic and public presentations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'POP SCIENCE' (2014-2020).

assistant: **Concept**

Our objective is to reach out to a large majority of the public who have not shown interest in science so far.  We want to make them aware of the major breakthroughs in physics, astronomy and related  applications of which they have heard from media worldwide, without understanding the profound implications on general knowledge and their spin offs on technology, as well celebrating the protagonists of these breakthroughs: researchers. We have chosen icons from modern culture – an innovative combination of poetry, art, theatre and consumers' gadgets (i.e. pop culture) – as communication vehicles, and a downtown trade center (including Geneva's FNAC) as a the venue. We will partner with a global consumer brand to support a pervasive awareness campaign. Poems inspired by recent discoveries in physics and astronomy,  produced by famous poets and university students (selected through an international contest) from at least 6 European countries will be presented on Researchers Night. QR codes of the winning poems will be distributed  on the night and subsequently in the subways of European capitals. The poets will have previously attended special seminars at CERN and other scientific laboratories about the new findings and thus be able to translate the scientific message in a concise and accessible language. Augmented reality, robots, QR-bar codes and explanatory video games,will be the highlight of a special tech section and a kids' corner, featuring CERN’s Marie Curie fellows, demonstrating these technologies and whom the public will ""speed-date"".Data used every day by the researchers to study the deepest secrets of nature will be transformed in visual art for interior decoration and become melodies played live by musicians and downloadable as smart phone tunes. At the PO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Limit strains for severe accident conditions' to be submitted under Fifth Framework.

assistant: **Abstract**

For severe accidents large structural deformations should be allowed with strain s reaching a certain fraction of the failure strains. But knowledge on the deformation capacity of relevant structures is lacking. Therefore the failure strains of essential reactor components are to be investigated. To apply small-scale model tests to reactor dimensions, size effects on the local failure strains are of special interest. Test families are defined with specimens of typical strain distributions caused by uniaxial and biaxial static and dynamic loads. Within one test family the geometries are similar, but the size is varied up to re actor dimensions. To deepen the understanding of structural degradation and fracture and to allow extrapolations, advanced computational methods will be developed and validated. Based on the results admissible strains will be proposed. This provides a means to show that existing reactors are able to withstand severe accidents.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Quantifying Uncertainty in Climate Projections including Biogeochemical Feedbacks' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

State-of-the-art earth system models used for long-term climate projections are becoming ever more complex in terms of not only spatial resolution but also the number of processes included in the models. Biogeochemical processes are just beginning to be incorporated into these complex models due to a difficulty in resolving heterogeneous biogeochemical processes. The motivation of this project is to quantify how climate projections are influenced by additional biogeochemical feedbacks that have not yet been taken into account in contemporary climate models. The researcher proposes an approach to look into coupled carbon-nitrogen-phosphorus-sulfur (C-N-P-S) cycle processes together with first-order physical processes. Biogeochemical studies show that C-N-P-S cycles are intimately interlinked via biosphere, resulting in an amplification of carbon cycle feedbacks. The proposed study will treat rivers and the global coastal zone explicitly, which are known to be essential for global biogeochemical cycle but are not represented in today’s earth system models. Uncertain parameters in the model will be constrained by an inverse estimation approach using various geophysical observations during the past millennium. The project addresses the following two questions: - Do coupled C-N-P-S biogeochemical cycles reduce the uncertainty in the past and present global carbon budget? - How much do coupled C-N-P-S cycle feedbacks contribute to the future global warming? How do they affect uncertainties? The interdisciplinary study will not only have a profound implication for future climate projections but also provide a new insight into outstanding research questions that cannot be answered in individual fields alone. Our research will serve as a pilot study to inform the climate researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Role of Aurora A kinase in establishment and maintainance of spindle bipolarity during mitosis' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

To be faithfully transmitted during cell division, chromosomes segregate on the mitotic spindle. The spindle assembles by the separation and migration of the two centrosomes nucleating microtubules either side of the condensed chromosomes. Aurora A kinase, whose gene is a human cancer susceptibility gene, appears necessary for correct spindle assembly. Nevertheless, how it orchestrates the process is not fully understood.We propose to study roles of Aurora A in regulating spindle function through motor com plexes and microtubules associated proteins responsible for the migration of centrosomes. The aim of this project is first to analyse the defects in mitotic spindle formation in living drosophila embryo mutant for Aurora A or injected with Aurora A inhibitors (molecules tested as anti-cancer agents in pre-clinical studies at Cyclacel Ltd).Secondly, I will study the role of Aurora A phosphorylation on potential substrates of the kinase associated with microtubules. I will use mass spectrometry to identify the phosphorylation sites. I will then mutate these sites and determine the effects upon assembly of the mitotic spindle. This project fits to a thematic priority of the FP6 program, namely to combat cancer.The combined use of embryo imaging, Drosophila genetics and biochemistry will allow us to understand fundamentals of a biological process of therapeutic interest in cancer treatment. The main skills required for this project are totally new for me as my former experience was in the characterisation of the IGF-1 signal transduction pathway by means of biochemical and cellular biological approaches in Huntingtons disease.Thus I am switching fields and joining a leading cell cycle group where I will become familiar with new methods and techniques. The opportunity to c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Investigate maternal and paternal risk factors for violence during pregnancy: lasting impact for everyone'.

assistant: **Innovation**

Globally, one in three women are estimated to experience physical and/or sexual intimate partner violence during their lifetime. Pregnancy is a life-changing time, when violence might subside, occur for the first time or intensify. Abuse and its consequences can be severe for both mother and children, and cascade into the next generation.IMPROVE_LIFEs aim is to understand the risk and protective factors for violence during pregnancy, its short and long-term effects and intergenerational impact.This project proposes the first theorization and empirical assessment of violence during pregnancy, its intergenerational transmission, and health and social effects using clinically tested biomarkers. It will synthesize new and existing intergenerational cohort data from diverse settings: Bangladesh and the UK, use pooled multi-country survey datasets and qualitative evidence.IMPROVE_LIFE will address five objectives: 1) investigate the short- and long-term social and health effects of violence during pregnancy on women and their children, 2) explore if violence during pregnancy is a marker for severe violence, 3) study maternal and paternal risk factors for the transmission  of violence to their children, 4) elicit male and female experiences and views of the causes of violence during pregnancy, and 5) provide evidence on the global applicability of established pathways explaining violence during pregnancy.The fundamental gains for the protection of women and prevention of violence emerging from this ambitious research programme are immense. The high risks arising from following a cohort after two decades, integrating clinically collected biomarkers and male voices are addressed by a dedicated and experienced PI and team and robust research approaches. The new empirically tested