RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Unravelling interactions between fermentable carbohydrates and the gut microbiota in patients with IBS' in the context of a Horizon Europe call.

assistant: **Objectives**

"What can I eat?” This is the question that patients with irritable bowel syndrome (IBS) ask their general practitioner. Diet is the first line of treatment for IBS and is based on restricting foods containing a group of sugars (Fermentable Oligo-, Di-, Mono-saccharides and polyol or FODMAPs), which are not fully absorbed by the host and fermented by the gut microbiota. Although effective, this treatment is not sustainable in the long term, as the diet requires limiting beneficial foods such as vegetables and fruits. To date, due to a lack of specific trials, our understanding of which and how specific FODMAPs contribute to IBS symptoms has yet to be uncovered.Based on (1) preliminary results showing a patient-specific response to purified FODMAPs in IBS patients, (2) the central role of the gut microbiota in FODMAP digestion and (3) the interindividual variation of the gut microbiota between individuals and IBS patients, I hypothesise that specific FODMAPs cause symptoms in IBS patients through individualised microbiome activity. By combining my bioinformatics skills and microbiome background with wet-lab microbiology expertise of the host group, I aim to identify bacterial species and metabolites causing the development of symptoms. Firstly, I will analyse samples and clinical data from a trial conducted in the host lab, in which patients were exposed to six purified FODMAPs, to identify microbiome changes in those experiencing symptoms. Next, I will test the interaction between FODMAPs and the identified microbes with high-throughput in-vitro fermentation, monitoring dynamic shifts in the gut microbial ecosystem and metabolic activity upon FODMAP exposure. Finally, I will determine if baseline microbiome or metabolite profiles can predict an individual's tolerance to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Demonstration of innovative solutions for  Reuse of water, Recovery of valuables and Resource efficiency in urban wastewater treatment' (R3WATER).

assistant: **Innovation**

Reuse of water, Recovery of valuables and Resource efficiency in urban wastewater treatmentThe main objective of the project is to demonstrate solutions that support the transition from a treatment plant for urban wastewater to a production unit of different valuables.So far waste water treatment plants are usually regarded as facilities to avoid emissions from wastewater. Current research and development shows that these plants can be converted and upgraded into production units to provide energy, nutrients, water for re-use and possibly other valuables.  This is achieved by improved resource efficiency in the plant as well as new technologies and business models that allow the re-use of resources from the incoming water.The 3 main objectives for the project are:•Demonstrate new technologies and solutions for increased resource efficiency in existing UWWTP performance thanks to innovative monitoring, advanced control strategies and management measures•Demonstrate innovative wastewater technologies that enable reuse of water, recovery of valuables such as nutrients•Facilitate market uptake for the demonstrated solutions for the European and global market by demonstrating solutions in different geographical context and reaching relevant stakeholders.The project will develop the following concepts for a number of important aspects to facilitate the transition to a production unit:•Resource and climate efficient treatment, thanks to:•Facilitating water re-use (e.g. monitoring)•Recycling of nutrients (and other valuables)Within the field of these topics, new and innovative technologies will be tested and demonstrated. For demonstration, 3 sites are involved in Belgium, Spain, and SwedenResults are disseminated to different stakeholder groups including Water treatment works,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Machine learning based Software Toolkit for Automated identification in atomic-REsolution operando nanoscopy'.

assistant: **Objectives**

In recent years, the analysis of large data sets is becoming increasingly important in the fields of material science and engineering. There is a strong demand for real-time automated identification algorithms in electron microscopy (EM) for the analysis of atomic-structure, phases, and defects. Unfortunately, it is non-trivial to obtain or extract meaningful scientific information from raw EM output digital data. It requires a tedious process of filtering/fitting and the expertise of a seasoned microscopist. With the rapid development of information technology and computer science, automated computer-assisted analysis of electron microscopy images/data is becoming a reality. In the past decade, different techniques have been developed and applied to digital data analysis. Meanwhile, the rapid development of novel microscopy techniques and instrumentation, e.g. in situ/operando and pixelated detector-based techniques, require high-speed data execution and analysis. Currently, several groups worldwide are concentrating their efforts into implementing machine learning and deep learning algorithms for image/data analysis. However, this is still a very undeveloped direction in the field of electron microscopy for materials science, especially in Europe. According to the Digital Transformation Monitor, artificial intelligence-based technologies will play a major role in future economy. The ability to analyse levels of data that are beyond human comprehension will allow business to personalize experiences, customize products and services and identify growth opportunities with a speed and accuracy that has never been possible before. The objective of this PoC is to generate an innovative software package that enables the analysis of large sets of EM data (i) at high throughput
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Improvement of Competitiveness by Distributed Component Based Development of Embedded Software' (DISCOMP), addressing dissemination and exploitation.

assistant: **Impact**

To maintain and further increase competitiveness on the market with respect to systems for hydrographic surveying, improvement in the efficiency of the geographical distributed development process of complex embedded software is required to meet different user requirements and to enable the cost-effective tracking of improvements in technology in the domain of sensor and data processing. As a key approach to achieve the higher extendibility, modifiability, portability and more efficient maintenance of embedded software systems a component based development approach, applying object oriented design principles, will be employed. To increase the efficiency of the required distributed development approach, Internet based communication technologies will be applied by the partners involved. Achieved improvements will be assessed in a baseline project w.r.t. software modifications based on the actually applied functional oriented development approach.Objectives:The main objective of the DISCOMP project is the introduction of a new SE methodology at SAM Electronics and ATB regarding a distributed software development process, which will enable achieving a higher extendibility, modifiability and more efficient maintenance of embedded software for hydrographic systems. The DISCOMP project will focus on the single, most critical step in this improvement process: Selection, introduction and testing of the Component Based Development methods and tools for design and implementation of software modules for a sensor based measurement system. The improvement will bring benefits in terms of savings in efforts/costs for extensions, modifications and maintenance by at least 50%, reduction of travelling and meeting costs by 60%, reduction of the time-to-market by at least 30% and reduction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Standardised extracts of Cannabis for use in the treatment of migraine and rheumatoid arthritis' in the context of a Sixth Framework call.

assistant: **Objectives**

Preparations derived from Cannabis nativa have been used as medicines throughout Europe and Asiasince the earliest written records, especially in the treatment of pain and inflammation. A number ofstudies have focused on specific aspects of Cannabis and its constituents, but very little commercialdevelopment activity has focused on the production of high quality, high value, standardised extracts(preferably low in the psychoactive constituent THC) which are orally active and suitable for clinicaluse. A recent large-scale clinical trial of cannabis in over 600 patients with multiple sclerosis, whilstgiving equivocal results on the amelioration of muscle spasm, showed significant effects on relievingthe associated pain. It is generally accepted that refined extracts of Cannabis, rather than singleconstituents, are more likely to yield an economically viable product. Commercial ventures have so farfocused purely on selecting 'appropriate' cultivars to protect individual patents, rather than establishingproper scientific criteria based on chemical and pharmacological requirements for developingtherapeutically active preparations. Production methods for establishing suitable standardized extracts,and subsequent pharmaceutical formulations (which would result in a valuable IP for any company),have not yet been at the centre of any serious R&D attention. This consortium of SMEs and universitiesintends to develop such extracts using in vitro and in vivo pharmacological methods, as well as ametabolomic profiling of the final products focusing particularly on arthritis and migraine. These aretwo therapeutic areas of pain and inflammation for which both anecdotal and scientific evidencealready exists, but which have not yet resulted in appropriate development of a commercial produ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MEasuring the Gravitational constant with Atom interferometry for Novel fundamental physics TEst', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Starting from the original experiment performed by Henry Cavendish more than two centuries ago, the precision determination of the gravitational constant G remains a challenging endeavour. It has been measured about a dozen times over the last 50 years, but the results have varied much more than what would be expected from random andsystematic errors. Likely, this is due to the fact that, so far, all the past experiments have relied on macroscopic classical instruments, which could all be governed by uncontrolled mechanical influences. On the other hand, a recent controversial study about correlations between the measured values of G and the variations of the length of day seems to suggest that some other not well-understood effects could be present.MEGANTE will address all these issues by carrying out precision G determinations making use of original experimental strategies based on quantum sensors. Unprecedented accuracy levels will be achieved using cold atoms in free-fall to probe the gravitational field, surpassing thus the state-of-art measurements based on torsion balance and simple pendulum.In parallel, MEGANTE will provide results that go far beyond the pure metrological interest. Indeed, owing the lack of a full understanding of gravity, several theoretical models predict new physics phenomena such violations of the inverse square law or a dependency of the G value from the local density of the matter. These aspects of the gravitational interactions will be thoroughly examined during the project, improving current constrains on those theories.MEGANTE will define a novel paradigm for precision G measurements and experiments on gravitation, paving the way for a final resolution of a two-centuries-old problem in metrology.


**Keywords:** Atom Interferometry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Vehicle, road, tyre and electronic control systems interaction: increasing vehicle active safety by means of a fully integrated model for behaviour prediction in potentially dangerous situations (VERTEC)'.

assistant: **Innovation**

Transport system safety is clearly one of the most important social problems, involving a lot of items as road, tyre and vehicle design. The proposed RTD Project faces the problem of Land Transport Safety aiming to improve Vehicle Active Safety by developing an integrated model for the simulation of the full system road-tyre-vehicle-driver in the most dangerous situations (presence of water, ice, snow, etc.), with special focus on the representation of HGV (Heavy Goods Vehicle) and the most advanced Vehicle Electronic Control Systems. These two items can be clearly seen as currently critical for the reduction of road deaths, since about 25-30 % of all road fatalities in Europe involve trucks and Electronic Systems are now becoming a global commodity. Such an integrated simulation environment will make possible to detect and rank the most dangerous situations and to define guidelines for the faster development of new safer products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Computational Studies of the Biogenic Amines of the Brain for Targeting Neurological Diseases' to be submitted under Seventh Framework.

assistant: **Abstract**

The main purpose of this computational research is to improve the understanding of a relation between features, metabolic pathways and signal transduction of amine neurotransmitters and the treatment of neurological diseases. Brain monoaminergic systems have been extensively implicated in the etiology and course of various neurodegenerative disorders, and their binding proteins such as receptors, transporters and common metabolic enzymes are the starting points for development of tools to diagnose and drugs to treat specific clusters of symptoms. Therefore, the research described here will be focused on two particular biological systems: monoamine oxidase enzymes (MAOs) responsible for regulating amine levels in the synaptic region, and histamine H1 and H2 receptors that regulate the activity of allergic and inflammatory mediator histamine. The work on MAO should aid in revealing molecular mechanisms of MAO-catalyzed amine degradation to their corresponding aldehydes, as well as of irreversible MAO inhibition related to the pharmacotherapy of depression, Parkinson disease and age-related cognitive disorders. This should help improve efficiency and reduce adverse effects of commercially available drugs, and should suggest novel classes of active compounds as transition state analogues. In joint computational/experimental efforts, studies on histamine receptors should unlock the secrets of receptor's distinction between agonist and antagonist binding using receptor deuteration, being of major relevance for molecular pharmacology. Overall, it is intended to identify ubiquitous trends and features that are applicable well beyond the scopes of these individual investigations. The proposed research is in general highly interdisciplinary with the promise of industrial applicat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'EMC and Safety Design for Photovoltaic Systems'.

assistant: **Concept**

Objectives of the Project The objective of the project is to prepare PV for the new market without compromises. Today PV systems have to fulfil tsvo different generic standards . The generic standard for residential, commercial and light industry and the generic standard for industrial environment. PV ss sterns have to satisfy the emmission-laws of the generic standard for residal and the immission-laws of the generic standard for industrial environment because the insert point of PV systems lies at a transition between both generic standards. There is still no standard for the product family" photovoltaic components and systems. Based on this results it could be necessary to propose additions to the existing standards or to propose a new product standard, which includes all important laws to develop and build PV systems with improved reliability, safety and quality. The guideline for this project is to check this existing standards whether they can lead to a safe and EMC conform product (e.g. components or systems). At test plants and systems deficits will come to light. The correction of these deficits leads to improved systems and to new laws and standards for construction and development of PV products. The success of the correction will be verified by measurement. Technical Approach The programme contents the following scientific and technical objectives: - Improvement of reliability, safety and livetime by reducing electromagnetic interference and suspectibility: conducted and radiated low and high frequency phenomena and electrostatic discharge phenomena. - EMC and safety measurements on really components and systems . - Creation of proposals for new standards of Electromagnetic Compatibility of Photovoltaic Systems in collaboration with IEC and CELENEC. All resu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pantograph Active Control System for e-Highways' (PACS).

assistant: **Concept**

Electro-mobility offers a variety of benefits. However, the electrification of road freight transport is not viable by using on-board storage of electricity. The electric roads can solve this problem by providing electrical power to the truck as it is driving through overhead electrical cables.However, the critical problem of electric roads is how to connect the truck, through the pantograph, to the power source. At speeds of 90 km/h, trucks must know the position of the cables 100-150m ahead in order to adjust the pantograph’s position in time to ensure that it correctly engages with the electrical cables.When using current solutions such as Radar, Lidar or Cameras trucks cannot travel at more than 30km/h and even so, often disengage from the cables. This is inefficient, dangerous and can significantly damage the cables. Today there is no technology that can detect and guide a pantograph at high speed and with the accuracy required to effectively charge the truck.At Qamcom Research and Technology AB, we have designed and tested an innovative solution named the Pantograph Active Control System (PACS) that enables fast communication between the energy source and trucks.PACS is composed of two elements:- Communicating devices located on every pole that transmits its position as well the position of the upcoming pole to approaching trucks- A high frequency radar located on top of the truck’s cabin that detects the transponder signalsAnd exhibits the following characteristics:- Modulation of radar signals- Short reading times enabling high speed data transmission- Detection of the geographical position of the data sourcesPACS has been tested within the e-highway context on an e-highway test strip in Sweden and has shown excellent results. We now what to use the SME instrume
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Microarray analysis of gene function and host interaction in salmonella typhimurium'.

assistant: **Concept**

This project will construct a complete gene array for Salmonella typhimurium and apply this array to identify genes whose expression changes under different environmental conditions, in different mutant strains, or through interaction with host cells. The array will be constructed from the full genomic sequence ofS.typhimurium using specific primers for each gene to ensure a complete and equal representation in the array. Selected chicken genes known or suspected to play a role in bacterial pathogenesis will also be included in the array, to allow the simultaneous analysis of changes in the bacterium and its host. Commercial partners in this project will investigate the novel genes and gene functions identified by this work more fully with a view to their exploitation for vaccine development and identification of resistant animals .