RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Strategic, Tactical, Operational Protection of water Infrastructure against cyber-physical Threats' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Water critical infrastructures (CIs) are essential for human society, life and health and they can be endangered by physical/cyber threats with severe societal consequences. To address this, STOP-IT assembles a team of major Water Utilities, industrial technology developers, high tech SMEs and top EU R&D providers. It organizes communities of practice for water systems protection to identify current and future risk landscapes and to co-develop an all-hazards risk management framework for the physical and cyber protection of water CIs. Prevention, Detection, Response and Mitigation of relevant risks at strategic, tactical and operational levels of planning will be taken into account to generate modular solutions (technologies, tools and guidelines) and an integrated software platform. STOP-IT solutions are based on: a) mature technologies improved via their combination and embedment (incl. public warning systems, smart locks) and b) novel technologies whose TRL will be increased (incl. cyber threat incident services, secure wireless sensor communications modules, context-aware anomaly detection technologies; fault-tolerant control strategies for SCADA integrated sensors, high-volume real-time sensor data protection via blockchain schemes; authorization engines; irregular human detection using new computer vision methods and WiFi and efficient water contamination detection algorithms). STOP-IT solutions are demonstrated through a front-runner/follower approach where 4 advanced utilities, Aigües de Barcelona (ES), Berliner Wasserbetriebe (DE), MEKOROT (IL) and Oslo VAV (NO) are twinned with 4 less advanced, but ambitious ones, to stimulate mutual learning, transfer and uptake. Building on this solid basis STOP-IT delivers high impact through the creation of hands-on traini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cryo-EM Imaging of Histone Recycling at the Replication Fork' (Cryo-H-Rec), addressing dissemination and exploitation.

assistant: **Impact**

DNA replication is essential for cell proliferation. In eukaryotic cells, DNA is densely packaged in nucleosome arrays that form chromatin. Such organisation protects the genetic material and controls access to DNA, thus providing an important mechanism for regulating gene expression. The eukaryotic replication machinery has evolved to unravel nucleosomes in order to access and duplicate DNA, while also maintaining chromatin density on newly duplicated DNA. To achieve this, the replisome dismantles nucleosomes ahead of the replication fork and reassembles them on nascent DNA strands, by coordinating redeposition of parental and newly synthesized histones. Histone proteins are subject to an array of post-translational modifications (PTMs), providing an epigenetic code that modulates activation and silencing of specific chromosomal regions. Redeposition of parental histones with their PTMs on both nascent DNA strands is, thus, pivotal in transmission of the epigenetic marks to daughter cells. I intend to perform in vitro reconstitution of the replisome on a chromatinised template and use cryo-electron microscopy to image DNA duplication and parental histone recycling at the replication fork. I seek to describe different structural intermediates in the process of nucleosome disassembly, DNA duplication and histone incorporation into new nucleosomes. To capture and characterise intermediate states of the replication machinery during this concerted process, I will employ a multidisciplinary approach and resort to structural techniques complementary to cryo-EM like solution NMR spectroscopy and crosslinking-mass spectrometry (XL-MS). My results will help dissect the role of different replisome components in nucleosome reshuffling at the replication fork, and elucidate the mol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Functional characterisation of the fish immune response to parasite' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

In humans, an effective defence against a particular pathogen requires a balanced differentiation between a type I and type II immune response. Prototypical type I and II immune responses are based on a different cytokine profiles in response to a pathogen. In humans, type I immunostimulator is Trypanosoma brucei,and type II is Schistosoma monsoni.We propose to study type I and type II immune responses in fish (carp: Cyprinus carpio) using a trypanosome (G. borreli) and a schistosome (S. inermis) infection mod el. Target parasites proteins will be identified by screening their cDNA library with parasite-specific host antibodies. Recombinant target proteins expressed in bacteria, and antibodies raised against these proteins will be used to study the subsequent type of immune response.Real-time quantitative expression of type I cytokines (IL-1, TNF) and type II cytokines (IL-10, TGF) will be studied in carp leukocytes stimulated in vitro with either T. borreli or S. inermis recombinantproteins. Cytokine profiles in vivo, will be studied following infection with either T. borreli or S.inermis or following injection with their target proteins. Nitric oxide (classical activation) and arginase activity (alternative activation) of macrophages stimulated with target proteins w ill be taken as further markers for respectively type I or type II response in fish. Blocking studies using antibodies raised against the target proteins of both parasites aim at inhibiting specific type I/II immune reactions and will help to establish their relative importance during infection.The present project aims to increase knowledge of the fish immune system and the control of fish diseases. The research objectives will help to understand the immune response type to different pathogens. This may l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Population age structure and age structure modification via Wolbachia in Anopheles gambiae' (ANOPOPAGE) under Seventh Framework.

assistant: **Objectives**

One of the most critical factors contributing to the vectorial capacity of malaria vector mosquitoes is the mean age attained by adult females, because after picking up the Plasmodium parasite there is a lengthy incubation period before transmission can occur. A virulent strain of the endosymbiotic bacterium Wolbachia called wMelPop reduces adult lifespan in its native Drosophila host, and has recently been shown to do the same following transfer into Aedes mosquitoes. We will examine its potential as a novel malaria control tool by creating and characterizing Anopheles cell lines containing wMelPop, and purifying and transferring it into An. gambiae by microinjection. We will then characterize the cytoplasmic incompatibility phenotype by which Wolbachia spreads itself, virulence (lifespan shortening effects), maternal transmission rates, and tissue distribution of introduced Wolbachia, together with analyses of mosquito gene expression using microarrays. Development of a molecular age estimation assay for the An. gambiae complex will be undertaken by adapting a new quantitative RT-PCR method for use in An. gambiae. We will then set up a greenhouse population of a member of the An. gambiae complex in Kenya that is viable over multiple generations, release marked mosquitoes to calibrate the molecular age estimation assays under semi-field conditions, and compare age structure between greenhouse and wild populations. In Burkina Faso we will estimate population age structure in the An. gambiae complex at 3 field sites, in different seasons and with / without insecticide treated net use. Liaison will take place with government institutions and local communities on regulatory issues and desirability of future Wolbachia-based trials in both countries. We will also build a sui
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Getting back to Growth through Technological and Managerial Innovation' (GGTMI) targeting Horizon 2020.

assistant: **Abstract**

The objective of the proposal is to examine ways to increase European growth through technological and managerial innovation. The technological innovation aspect is focused on examining the lifecycle of innovators and entrepreneurs across several advanced countries. We will examine the impact of financial constraints, tax and schooling policies on stimulating greater innovation. The second theme will examine by how much managerial practices can account for differences in the wealth of nations and how management quality can be improved, focusing on randomized control trials of business support polices. In addition to conducting our own surveys and drawing on administrative data, we will use Big Data techniques to measure management and corporate culture within firms. As a package this will constitute a ground-breaking piece of social science that will change the way we think about what drives prosperity across firms and countries. We are confident that this will lay foundations for better policies in Europe and elsewhere to help improve growth.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Quantifying cyber risk:  a computational insurance approach'.

assistant: **Innovation**

Quantifying cyber risk is an important step in assigning resources to prevention.  Yet data limitations mean that current estimates ignore certain incidents (e.g ransomware), rarely provide the financial cost, and cannot describe how risk varies based on the firm’s revenue or industry.  Surprisingly insurers sell cyber insurance for the ignored incident types and vary the price based on firm-specific characteristics.  Extracting insurers’ cyber loss models could help firms manage risk, regardless of whether they purchase insurance.  The proposed action (QCYRISK) uses an iterative model fitting approach to infer loss distributions from insurance prices.    The first research question develops the conceptual foundations by building an economic argument about how much information can be extracted from insurance markets.  QCYRISK's second question seeks to infer full cyber loss distributions, including how they vary based on firm-specific characteristics.  The final research question adopts an adversarial machine learning approach to probe the validity of the inferences, using both synthetic distributions and real cyber crime data.  In terms of results and dissemination, QCYRISK will provide a set of loss distributions for multiple cyber incident types adjusted based on the firm’s revenue and industry.  These will be made available as a spreadsheet for real-world risk managers.  We will also run a continuing education seminar for insurance professionals to raise awareness about the method.  The developed method represents a new computational insurance technique that could be applied to extract information from a global total of €4.7 trillion insurance premiums.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bombay Cinema's Encounter with the 1960s' (2007-2013) under Seventh Framework.

assistant: **Objectives**

This project looks at the cultural resonance of the 1960s in the world of Bombay cinema. Indian cinema’s transition from black and white to colour produced an affective force field that impacted on the choice of locations, forms of mobility, the designing of interiors, the role of music and the cultural politics of stardom. Equally the 1960s was the decade of tourism.Tourism’s imaginative force taken together with the arrival of colour can open the window to an understanding of a transnational cinematic force that has not received adequate attention in the chronicled histories of Indian cinema. Travel across India’s landscape became a recurring feature in films, with trains and automobiles as the chosen modes of transportation. Thus, the hill station emerged in the 1960s as a picturesque space for romance. Exploration narratives abound in this decade with picnics, holidays, and other journeys forging an entirely new imagination of space. The fascination with landscape became critical to a new conception of the “outdoor” that looked distinctly different from earlier films. While the train and the automobile were mobilized for travel across India, by the mid 1960s we see the discovery of the “global” in a cluster of films that showcased travel to foreign cities like Paris, London, Tokyo and Rome. The travel narratives combined spectacular outdoor locations with lush interior spaces that included fashionable nightclubs, hotels, and lavish homes. The world of objects in interior spaces had to be organized for its capture on colour film stock, slowly changing the perceptual economy of the frame. Alongside these changes we witness shifts in the culture of stardom linked to new international currents in music, dance, fashion and youth culture. This project seeks to unpack the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A novel pathway for generation of building blocks for antibiotic biosynthesis' (CaLiAT), addressing dissemination and exploitation.

assistant: **Impact**

The development and spread of antibiotic resistance in microorganisms is a major threat to both humans and animals and the search for new and improved drugs is of high importance. Natural products are experiencing a strong revival as leads in drug development, and biosynthetic engineering offers sustainable routes to new and potentially improved analogues. Finding new ways to make these rational changes should ensure that the European Research Area remains competitive in realising the potential of this technology. The aim of this project is to gain a detailed understanding of a newly-identified family of enzymes supplying unusual fatty acid building blocks for assembly-line biosynthesis of natural products; and to exploit these insights to develop more efficient strategies for targeted alteration of their structures. The novel precursor enzymes to be studied, a ligase and a biotin-dependent carboxylase, are in pathways to several polyketides produced by actinomycete bacteria.The project divides into three parts. First, additional examples of the new pathway will be sought by targetted whole-genome sequencing, as well as bio-informatic analysis of published sequence databases, and gene knockouts used to confirm the role of the pathway in providing polyketide extender units. Secondly, candidate ligases, carboxylases and the cognate acyltransferase domains that specifically recruit the unusual extender units will be studied in vitro for substrate specificity and for their ability to accept non-natural substrates bearing chemical functionality. Finally, a range of non-natural fatty acids will be fed as precursors to engineered strains designed to produce novel polyketide analogues. This approach should significantly expand the available pool of polyketide diversity. At the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Accommodating Creative Knowledge: Competitiveness of European Metropolitan Regions Within the Enlarged Union' (ACRE).

assistant: **Concept**

In this project we aim to assess the impact of the emerging creative class" and the rise of the "creative industries" on the competitiveness of EU metropolitan regions. While the traditional "hard" location factors that firms use will remain important for international competitiveness, new "soft" location factors that are mainly related to attracting the required "talent pool" would deserve increasing attention. The central research question we will address is: what are the conditions for creating or stimulating "creative knowledge regions" in the context of the extended European Union? We will compare the recent socio-economic development trends and strategies in several metropolitan regions across Europe to get more insight in the extent to which creativity, innovation and knowledge are indeed the keys to a successful long-term economic development. The metropolitan regions in the ACRE project are: Amsterdam, Barcelona, Birmingham, Budapest, Dublin, Helsinki, Leipzig, Milan, Munich, Poznan, Riga, Sofia and Toulouse. With the results of this study the EU might seriously consider strengthening the profile of metropolitan regions within the EU area as regards creative knowledge branches and activities in the face of increasing competition with other growth regions in the world. The most important topic to consider is which metropolitan regions might develop as "creative knowledge regions", and which regions might not. This will depend on current positions in global and European networks and on historic development paths. In this research leading European experts with complementary disciplinary backgrounds from places with clearly different pathways concerning the creative knowledge economy will be brought together. This will help to significantly improve our understandin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Social and ecological networks supporting biodiversity and food security'.

assistant: **Innovation**

Halting biodiversity decline and ensuring food security are urgent and interconnected challenges. I will study how social and ecological structures in interaction generate tradeoffs and synergies between food security and biodiversity conservation. SENet has two aims: A) to identify ecological and socioeconomic structures that benefit or harm food security and biodiversity conservation in a rural, poor study landscape, and B) to develop an integrated network model capable of predicting such effects in similar settings worldwide. Globally, SENet will be the first research to apply (graph-theoretic) network analysis to understand synergies and tradeoffs in the food security–biodiversity nexus. I will develop the integrated model using data from a landscape in Ethiopia, where agricultural expansion and human-wildlife conflicts are driving deforestation. SENet differs from existing approaches that concentrate on increasing agricultural output and overlook that social and ecological outcomes are interdependent and cannot be understood separately. In contrast, my method focuses on the food security of rural villages and on the factors that prompt farmers to clear or to plant forest, to change crops, to migrate elsewhere, etc., i.e., on farmers' decisions that affect both food security and biodiversity. In this context, I will use systematic network analysis to show how farmers are connected through food trade, knowledge exchange and other socioeconomic processes, but also how their crop fields are linked to forests and human–wildlife conflicts. The implementation of SENet will draw on my skills in network analysis and the host’s research excellence on the biodiversity of agricultural landscapes, including their ongoing fieldwork in my study area. This setup ensures a theoreti