RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Next Generation Knowledge Management for Small and Medium sized Enterprises' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The requested fellows will perform researches that enable development of next Knowledge Management (KM) based groupware application. As software development continuously demands close co-operation between development and research the fellow will base practical results on scientific research. The fellowship this way represents a high industry value and the fellow has the opportunity to build an example of industry take up of academic approaches. Five key enablers will constitute the interdisciplinary and intersectorial basis for global KM research approach of AWARE, directly implemented into the training programme. This programme will also provide them with knowledge on research management mainly based on practical experiences through their involvement in European or national research projects currently taking place at CAS Software. Finally fellows will be trained on rhetoric, presentation and negotiation techniques and time management. According to the specific need of the individual fellow and to their Personal Career Development Plan, an individual training plan will be set based on the existing training programme. Each fellow will be affected to one specific research group of CAS for the whole duration of its fellowship. The Multidisciplinary Research Group will both uptake fellows if requested and coordinate the whole AWARE project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New Foundations for Real-World Cryptography' (REWORC), addressing dissemination and exploitation.

assistant: **Impact**

Almost half a century after the invention of public-key cryptography, there is still a vast discrepancy betweenthe theory and practice of cryptography. With some notable exceptions, research from the cryptographic theorycommunity focuses on problems of great theoretical interest, albeit completely disconnected from the real world. On the other hand, widely used real-world cryptographic protocols are being neglected because they are either mathematically ugly, their solutions appear uninteresting, or they simply do not cross the mind of theoreticians. The current state can be summarized as follows:• Several well-established theoretical cryptographic concepts fall short from properly modeling the way practitioners think about real-world cryptography• There exists a surprisingly large amount of modern cryptographic primitives and standards with unclear provable security status.The central objective of the REWORC project is thus to narrow the gap between theory and practice of cryptography, providing a solid theoretical groundwork for real-world cryptography. To this end, we will• lay a new theoretical foundation for real-world cryptography in the elliptic curve setting• develop new tools and models for the design and analysis of practical cryptography in the post-quantum setting• revisit the concrete security of legacy cryptography from the 2000s, recently established standards, and forthcoming standards.REWORC will have a substantial long-term impact on theoretical protocol design, influence ongoing standardizationefforts in post-quantum cryptography, and settle doubts about the security of important cryptographyused in practice.


**Keywords:** Theoretical cryptography, provable security, security reduction, post-quantum cryptography, real-world cryptography
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Making patient-derived tumor organoids a reliable cancer therapy testing platform', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

We aim to establish a European network of experts in non-animal preclinical models to develop the next generation of patient-derived tumor organoids (PDTOs) for both solid and hematological cancers. To this end, we have selected non-small cell lung cancer as a model, given its high incidence, and chronic lymphocytic leukemia and follicular lymphoma as representative B cell malignancies.These PDTOs will incorporate a novel, tissue-specific artificial extracellular matrix, created using tailored 3D biohybrid hydrogels designed to mimic the human tumor microenvironment (TME). By integrating patient-derived tumor, immune, and stromal cells, the PDTOs will closely replicate the complexity of the original tumors, which will be evaluated using a multi-technique approach, including comprehensive omics characterization.Our ultimate goal is to establish a robust platform for testing innovative therapies—particularly radiotherapy and immunotherapy—within the framework of personalized medicine. Specifically, we will focus on adoptive cell therapies using CAR T and NK cells, neutron capture (radio)therapy, and their combination.


**Keywords:** Biomaterials, Tissue Engineering, 3D Biohybrid Hydrogels, Organoids, Non-Animal Preclinical Models, NSCLC, CLL, FL, Immunotherapy, Neutron Capture Therapy, Cancer, Personalized Medicine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Understanding the mechanisms behind tree responses to drought-induced stress with increasing tree size'.

assistant: **Concept**

Plants adjust leaf water potential and hydraulic conductance under drought through stomatal behaviour, reducing sap flow and protecting plants from extensive water loss and embolism. Due to the negative effect that vapour pressure deficit (VPD) and tree height have on canopy-scale water conductance (G), Darcy’s law predicts a decline in G due to the expected increase in VPD following climate warming, to which tall trees would be presumably more sensitive. Further work is thus needed to understand the effect that tree size has on tree response to increased VPD and drought. This project aims at (1) testing whether, at a given VPD, trees adjust different functional traits to compensate for the negative effect of height on G in (a) tropical forests and (b) at a global scale, and (2) describing the mechanisms behind these adjustments and the potential interactions with other functional processes that may impair tree response to drought stress with increasing size. We will first measure multiple functional traits (including sap flux, gas exchange and leaf and xylem water potential) on trees of different heights to test Darcy’s law predictions and evaluate the role that the trade-offs among traits play on enhanced vulnerability to drought with increasing tree size in tropical forests. In order to assess whether the studied mechanisms prevail across species and ecosystems, we will perform a global-scale analysis of sap-flow and, thus, G responses to VPD as a function of tree height using the sap-flux data from 159 species and nine different biomes gathered within SAPFLUXNET. This integrated analysis will provide a better understanding of the role that tree size plays in tree vulnerability to drought in the short (temporary physiological response) and long term (legacy effects),
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Electron-scale dynamics in chemistry' (ELYCHE) under Seventh Framework.

assistant: **Objectives**

The target of the proposal is the first experimental demonstration of attosecond coherent control of electron motion in many-particle systems. The past decade has seen remarkable advances in the field of coherent control of chemical reactions thanks to the application of femtosecond technology; I propose to use the emerging attosecond technology to achieve coherent control of photodissociation reactions on a purely electronic scale. I will mainly concentrate on molecules with biological interest. The success of the project will be based on the possibility to initiate and control the sub-femtosecond electronic motion in large molecules, by using high-intensity isolated attosecond pulses. Such electron motion precedes and determines the subsequent nuclear rearrangement, which ultimately leads to the chemical change. In this way it will be possible to control in a direct way the outcome of a chemical reaction, which is one of the central problems in modern chemistry. A crucial benchmark of the project, substantially beyond the current state-of-the-art in Attosecond Science, will be the experimental demonstration of attosecond pump / attosecond-probe measurements, which for the present are not technically feasible. Electron dynamics will be measured, with attosecond resolution, in many-particle systems, ranging from simple molecules to complex bio-molecules.The application of attosecond pulses and the development of attochemistry techniques for the investigation of the primary electronic steps of chemical processes, is a completely new and challenging research field, with tremendous prospects for both fundamental research and technology. In particular, the attosecond coherent control of charge localization in bio-molecules can offer unique information on the mechanisms at t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'REliability and Safety Engineering and Technology for large maritime engineering systems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Failure of large complex engineering systems often leads to catastrophic consequences. Their efficient and safe design and operation will avoid or reduce malfunctions, failures and accidents, which would have a significant impact on the daily life of the public in terms of service and product delivery, business interruption, economic losses, human injuries/fatalities, and property and environmental damage. The proposed project aims to develop and apply knowledge in Reliability and Safety Engineering and Technology (RESET), for safe and reliable design and operation of large maritime (marine and offshore) and other made-to-order (MTO) engineering systems. This multi-disciplinary and inter-disciplinary project of 48 months’ duration, will formulate a consortium of complementary expertise targeting areas of academic and industrial importance. In particular, a series of integrated activities will investigate i) the framework for reliability and safety assessment, ii) system risk and reliability modelling under uncertainties, iii) fluid and structural modelling under uncertain environments, iv) fatigue and fracture assessment, v) decision making together with case studies, and vi) the development of guidelines for general application of the developed models. The engineering systems that are addressed in this project include: a) ships, b) offshore installations, c) offshore wind farm units and d) other MTO engineering structures/units. In order to achieve an integrated project, all the ESRs and ERs involved will conduct their model development and application within the RESET framework. Novel and flexible models for addressing the identified research needs will be developed for application in situations where conventional approaches may not be confidently applied due to incom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Chronic microvascular disease in the brain and mechanisms of age related functional impairments' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives: The project would test the following hypotheses concerning the mechanisms leading to deve!opment of leukoaraiosis: 1. Leukoaraiosis results from diffuse decreases in subcortical capillary density that lead to chronic subcortical ischaemia. 2. Axonal damage or loss is a major cause of the chronic functional impairments associated with leukoaraiosis 3. Microvascular disease leading to leukoaraiosis is associated both with altered coupling of local haemodynamic responses to neuronal activation and with altered functional connectivities between cortical networks activated during cognitive tasks.Chronic microvascular disease of the brain is a major cause of motor impairment and dementia with aging. Early diagnosis and treatment have been limited by the lack of reliablenon-invasive markers of disease. Although widespread periventricular white matter changes described as leukoaraiosis are characteristic of the MRI brainscans of affected individuals, the significance of these changes is uncertain, as they also can be found with apparently healthy aging. Such variable severity of clinical deficits associated with similar appearances by conventional imaging must reflect considerable pathological heterogeneity underlying the changes of leukoaraiosis. This proposal would link expertise in four European research centres for the coordinated application of positron emission tomooraphy (PET), magnetic resonance imaging (MRI) and spectroscopy (MRS), and functional magnetic resonance imaging (FMRI) for better characterisation of the pathophysiology of aging-related chronic microvascular disease of the brain. The healthy aging patients with leukoaraiosis with or without dementia and patients with chronic hypertension who are at risk of developing leukoaraisosis would be studie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A High-Throughput Approach for Chemical Reactivity Profiling and Physical Organic Chemistry' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This research proposal challenges current philosophy in reaction analysis in that it offers a HT approach to the generation of reactionparameters orders of magnitude faster than those currently used; although offering data that is as accurate and as robust (if not more so)than traditional methods. The aims of this proposal are to initially undertake a systematic and quantitative evaluation of a simple test casesinvolving relative amino acid coupling rates before extending studies into the area of nucleophilicity in association with solvent effects but with analysis in an entirely self-consistent and self-correcting manner, Subsequently, the studies would be extended to ananalysis of Buchwald-Hartwig based chemistries and a series of phenols and anilines with the focus on Hammett based analysis of coupling partners. Such an approach will have many practical applications. Thus it will allow the chemistry/activity of new monomers to be determined before application in library synthesis, besides offering an understanding of the suitability of existing monomers in library based SNAr chemistries, and the global analysis of coupling reagents with all amino acid coupling partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Version management with software reuse across multiple platforms and projects', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

To reduce the time and cost overhead associated with collection, documentation and maintenance of reusable software modules. A base of reusable software source modules and drivers creates a software foundation, which significantly reduces the total development time for a software project and time-to-market for new projects. Such a software base contributes significantly to the competitive power of a company. Normally reusable software modules will be extracted from on-going software development projects, and adapted and documented for reuse in future projects, and as time evolve the most popular software modules usually exist in multiple versions for different embedded processor types and platforms. The goal with this PIE is to be able to increase the birth-rate of reusable software modules and to prolong the operational lifetime of existing reusable modules, with a minimum effort in hours of work. The focus will be on achieving better management and design methods with respect to potential reuse, so the amount of software modules, which afterwards can be extracted from the existing designs and incorporated in the base of reusable software source modules, are increased. An important underlying part of this reuse management improvement is better capability to keep track on current version and revision state of the reusable software modules during the continuously on-going extraction and updating process.THE EXPERIMENTThe experiment will be carried out over 2 software development projects (customer development orders) where reuse characteristics for the projects are measured. During the preparation phase of the PIE new CASE tools are taken in use, and new strategies are introduced. The first customer order acts as a reference and the reuse improvements are measured after
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Continuums Of Game NETs: swarm intelligence as information processing (CoGNETs)'.

assistant: **Objectives**

CoGNETs aims to revolutionize the Intelligent Infrastructure Management by introducing a scalable and interoperable distributed Middleware Framework for autonomous IoT-to-Cloud computing, sustainable during and after the project via FIWARE Foundation (Technical Manager) and supported by a strong Industrial & Academic EU-JAPAN ecosystem led by AVL (leader of Catena-X initiative between EU-JAPAN in data sovereignty for the Automotive & Manufacturing supply-chain).The idea is to leverage the IT intelligence to the point where devices can self-realize their heterogeneity and self-decide how to form dynamic IoT-to-Cloud swarm continuums for responding to common AI tasks and significant items of cognitive computing in automated, secure and energy efficient fashion.At is core our Middleware will integrate new decentralized federated multi-context Broker architecture enriched with Game-intelligent Agents, Collaborative Federated Learning and End-to-End Security mechanisms (including RISC-V hardware security & AI acceleration) to effectualize dynamic data and resource management across devices at different domains, thereby using open-source programing models and APIs to produce new orchestration, optimization, etc. routines with no vendor locking.CoGNETs will also achieve energy/CO2 neutrality and “by-design” security awareness by leveraging all its Middleware processes over unified Computing-Energy-Security optimization, thereby introducing a new logic to systemically improve Computing in joint and equal terms to Energy and Security performances that are necessary for sustaining new services and business models.Validations will be taken over 3x vertical and 1x cross-vertical Demos to support emerging Manufacturing, Mobility and Health sectors, and to examine how CoGNETs can saf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Uncultivated Microbes In Situ - a Computational Biology Approach to Determine Molecular Capabilities and Ecological Roles' (UMICIS) targeting Seventh Framework.

assistant: **Abstract**

Most of nature s biodiversity, and many potentially useful metabolic capabilities, remain hidden among the vast numbers of uncharacterized environmental microbes. Because cultivation is still not possible for most of these microbes, cultivation-independent molecular techniques such as polymerase chain reaction (PCR), fluorescent in situ hybridization (FISH), or shotgun DNA sequencing have been used in order to study their function and ecology in their natural habitats. However, none of the above techniques have so far been sufficient for any systematic assignment of molecular functions to distinct microbial lineages. Thus, most of the molecular ecology of natural microbes remains elusive. Here, we propose a computational meta-analysis and synthesis of existing and newly generated molecular sequence data sampled directly from the environment combining DNA sequencing data (metagenomics), and proteome expression data (metaproteomics). This analysis will be coupled to computational modelling of genome content evolution at the community level. We will aim to assess how gene repertoires of microbial communities, and their taxonomic compositions, change across distinct environments, in response to changed conditions, and through time. We plan to address fundamental questions in microbial ecology, including the extent of cooperation among members of the communities, stability of community composition at evolutionary timescales, the importance of lateral gene transfers, the extent of functional adaptation/regulation in situ, and whether gene occurrence and expression patterns are diagnostic of community functions and ecological status.