RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Multisite phosphorylation in biomolecular condensates.'.

assistant: **Innovation**

Biomolecular condensates are membraneless organelles that serve as specialized phase-separated microenvironments within which many cellular processes can occur efficiently and with precise spatial and temporal organization. As such condensates are an important target for scientific research because they can be used as regulatory mechanisms to turn cellular processes on or off. Condensates comprise flexible multivalent biomolecules with multiple binding sites. This allows them to interact with various molecules simultaneously, enabling biomolecular clustering that can lead to phase separation. Kinase phosphorylation is a critical mechanism that triggers formation and dissolution of condensates. Once formed, condensates display emergent properties, which arise due to the collective behavior of their component biomolecules. I propose to investigate the mechanism of consecutive catalysis by kinases within condensates, and how the properties of condensates affect kinase activity. I will use synthetic condensates containing a minimal model kinase substrate that strongly partitions Protein Kinase A to examine kinase reaction kinetics in vitro and in vivo. The experiments described within will elucidate whether kinase catalysis proceeds distributively or processively within condensates. The proposed research will identify the fundamental principles of kinase-dependent condensate regulation, particularly the impact of multi-site phosphorylation on the regulatory dynamics controlling condensates. Since condenstates and kinases form a mutually responsive system regulating many basic aspects of cellular physiology, understanding how they interact will provide greater knowledge of disease mechanisms. By unraveling the intricacies of these molecular interactions, I will uncover novel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Probing the role of orphan Cytochrome P450 oxygenases in signaling compounds biosynthesis in plants by a comparative genomics and gene conservation approach'.

assistant: **Objectives**

A limited number of molecules have been characterized as plant growth regulators or hormones, usually identified due to the strong effect that they exert on plant architecture or development. Most of the metabolic pathways leading to their biosynthesis and catabolism are now well characterized, and all but one involve oxygenases belonging to the family of cytochrome P450 (P450) oxygenases. The increasing set of sequenced plant genomes reveals the evolutionary history and complex phylogeny of the P450 superfamily. It shows that some P450 genes are specific to taxa or evolutionary branches, which correlates with the versatility of plant metabolomes when different species are compared. But comparative analysis of plant genomes also point to ancient genes, highly conserved and under strong purifying selection. Those are most often involved in the metabolism of molecules essential for plant development and with signaling function. Taking advantage of the increasing power of comparative genomics, we propose to identify P450s that share similar evolutionary characteristics with their counterparts in known hormone metabolism. We propose to perform a comprehensive functional analysis of a set of candidates, using the easiest plant model Arabidopsis thaliana, and to assess their role in the biosynthesis or degradation of signaling compounds. This includes establishing a detail map of candidates’ expressions to evaluate their place and time of action, and a phenotypic analysis of inactivation mutants and overexpressors to assess the consequences of gene misexpression on plant development. Based on gene expression and potential mutant phenotypes, we will select tissues to be analyzed for metabolic changes associated with gene mutation using high-definition analytical tools. Enzyme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'UNMANNED TRAFFIC MANAGEMENT 4D PATH PLANNING TECHNOLOGIES FOR DRONE SWARM TO ENHANCE SAFETY AND SECURITY IN TRANSPORT' (LABYRINTH).

assistant: **Innovation**

Ensuring transport safety and security is one of the EU’s main priorities, as spotlighted in WHITE PAPER–Roadmap to a Single European Transport Area, which sets out a strategy leading to reach a safer, more efficient and more sustainable civil road, rail, air and waterborne transport. Drone applications are considered as potentially capable of revolutionizing the world around us. Nevertheless, security issues make impossible to fly drones in most situations, due to drone guidance and control-related technologies have not reached enough readiness level to guarantee safe operations in most of low altitude scenarios.To face these issues, SESAR has created U-SPACE, a new framework designed to integrate safely, securely and efficiently drone operations at low level into EU airspace. Active geofencing is one of the main drone emerging technologies outlined in the U-Space Blueprint. However, although geofencing is a useful technology to avoid drones presence in restricted places, it is not prepared to face the future proliferation of drones in areas such as cities, where drone swarm applications will  lead to an increasing risk of collisions. LABYRINTH has identified the need to research on centralized planification systems capable of communicating with the drones in a certain area, processing their desired origin and destination points and compute paths to avoid collisions. This is embodied in the Unmanned Traffic Management Systems (UTM) that, in contrast to EU strategy, are one of the NASA’s main research priorities, whose objective is to create flight control centres for auto-piloted drones.Aligned with this, LABYRINTH aims to use this new approach to create a U-SPACE-based technology to make a leap forward in the efforts undertaken so far through the development of autono
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of a bioartificial pancreas for type I diabetes therapy' under Sixth Framework.

assistant: **Concept**

Four to five million people in Europe and about 80 million worldwide suffer from type 1 diabetes (insulin-dependent), characterized by a deficiency in insulin secretion resulting in hyperglycaemia responsible for debilitating long-term complications (coronary diseases, acquired blindness, chronic renal failures). Recently developed immunosuppressive protocols improved the success of humanallogenic pancreatic islets transplantation. However, such transplantation has severe limitations: the number of available donors and the potential toxicity of the immunosuppressive treatments. To avoidimmunosupression, islets could be encapsulated to protect them from the attack of the immune system and thus from rejection.This project intends to develop, improve and validate an efficient reliablebioartificial pancreas for human application. To achieve this ambitious goal, various disciplines reintegrated in a true task force of basic and clinical researchers with leading expertise in experimental diabetes and advanced modern material technologies to develop an effective approach for the treatment of type 1 diabetes. The proposed approach takes into account the far-reaching advances in the modernnanosize technology, which are of utmost importance for the success of this challenge. To canny out the project to a successful achievement, the consortium gathers a multidisciplinary group of leading European scientists with complementary competencies, spending from biomaterials to tissue engineering, and high-tech Sees. This transactional approach provides convincing solutions to bypass the limitations of traditional treatments of this disease. That proposal fits perfectly within the scope of Priority Nan technologies and Nan sciences, 3.4.1, in particular Biotechnologies-biotechnologies, 3.4
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Open Mashup Enterprise service platform for LinkEd data in The TElco domain', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The convergence of Telecom, IT and content services drives new emerging service markets based on an open Internet of Services. Mashups have gained big success in the so-called Web 2.0. The success of the Web 2.0 services has encouraged Telcos to expose their assets as Telco services in order to provide third parties with facilities to build their business. Moreover, the exposure of network infrastructure as services is facilitating the entry of new API-driven telco agents that bring traditional telco services (telephony, messaging, IP location, etc.) to the Web.<br/>Yet, the technologies underlying each of the different mashup types are heterogeneous, which makes integration challenging. Also, mashups do not offer a universal composition model either, since mashup development is not vendor independent.<br/>In this landscape, OMELETTE aims at researching on the development, management, governance, execution and conception of converged services with a specific focus on the telco domain. OMELETTE will create a sound model of mashups that follows the REST architectural style (also supported by standard widget technology), as well as a standard specification of a mashup-containing platform that may guarantee portability and interoperability among different vendors and versions. These concepts will be based on a solid theoretical model of mashup foundations and the specific requirements gained from the telco domain. OMELETTE will aim at breaking the barriers between the web, telecommunication and hybrid services, taking into account the convergence of IT/telecom/content systems. OMELETTE will foster as well the reuse of existing components and mashups, thanks to its automated service discovery functionalities. Project OMELETTE aims at developing an open platform for building
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'City buzz: Quantity, quality, and variety implications of the urban environment' to be submitted under Horizon Europe.

assistant: **Abstract**

This research project aims to understand the changing landscape of cities. These are cities where face-to-face interactions happen less around office water coolers and more on the streets; where individuals not only produce differently by location but also have heterogeneous consumption; and where, beyond the adoption of working from home, the transformation of work involves a reorganisation of firms' establishments and hierarchies across locations.To capture face-to-face interactions accurately, we use anonymised cellphone records to identify spatial and temporal overlaps among users who also have phone conversations. By combining location and call data, meaningful interactions are distinguished from passing strangers, while quantifying social connectivity and distinguishing between strong and weak ties. The project examines variations in quantity, quality, and diversity of face-to-face interactions across spatial contexts. It isolates the effects of the urban environment from personal characteristics by studying individual changes following shocks.The project also investigates consumption differences across locations. It uses anonymised credit card data to examine the quantity, quality, and variety of consumption venues, going beyond locally available venues to explore how individuals utilise them and accounting for endogenous amenities and location choices. We consider co-consumption evidence, residence, and job information to understand leisure interactions among neighbours, co-workers, and friends.Finally, we explore changes in the hierarchical organisation of firms across space. Using matched employer-employee data and a model of cities and hierarchies, we investigate how firms organise establishments and managerial hierarchies across locations. Moreover, we exami
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Understanding kilonova diversity using radiative transfer simulations with realistic binary neutron star merger ejecta'.

assistant: **Concept**

The merging of binary neutron stars produces an explosive kilonova transient, recently confirmed by the first ever detection of a kilonova, AT2017gfo, coincident with a gravitational wave signal, GW170817. The wealth of observations provided by AT2017gfo offers the opportunity to probe the fundamental physics of binary neutron star mergers, including the incompletely known Equation of State of dense nuclear matter and rapid neutron capture nucleosynthesis (the r-process), which produces half of all elements heavier than iron in the Universe. With the detection of AT2017gfo and the new gravitational wave observing run of LIGO, VIRGO and KAGRA (O4) the demand for kilonova simulations has never been so great.The aim of this research is to produce sophisticated, three-dimensional kilonova radiative transfer simulations from binary neutron star merger ejecta with detailed r-process calculations, allowing simulations to be directly compared to observations. I am uniquely placed to combine these complex simulations to self-consistently model kilonovae, enabling powerful constraints to be placed on the underlying physics through interpreting kilonova observations. I will carry out the first three-dimensional kilonova parameter space study based on realistic hydrodynamical neutron star merger simulations with a range of neutron star masses and Equations of State. The simulations will predict spectra using a state of the art line-by-line opacity treatment for millions of line transitions of r-process elements, which allows spectral features to be directly associated with the ions responsible for forming the features.This multi-disciplinary approach will constrain and improve hydrodynamical neutron star merger modelling, kilonova radiative transfer simulations, the high density Eq
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sources of Legitimacy in Global Environmental Governance' in the context of a Seventh Framework call.

assistant: **Objectives**

Most global governance efforts rest on fragile foundations as long as their legitimacy within national political systems remains contested. Legitimacy denotes the “capacity of the political system to engender and maintain the belief that existing political institutions are the most appropriate and proper ones for the society.” (Lipset 1983:64) The proposed project examines the sources of legitimacy and thus also public support for global governance. It focuses on procedural and outcome related sources of legitimacy; that is, how decisions in global governance systems are made (procedure), and how the benefits and costs of governance are allocated (outcome). Empirically, it concentrates on climate change, the most paradigmatic case of a global governance challenge. On the procedural side, the project explores the implications for legitimacy of variation in international decision-making rules, civil society participation, and involvement of international organizations. On the outcome side, it examines the implications of variation in outcome favorability (absolute gains/losses), burden/benefit sharing (outcome fairness, relative gains/losses), and reciprocity. It relies on survey embedded experiments in the laboratory and via a crowd-sourcing platform, as well as geographically representative survey experiments in five countries: Brazil, China, Germany, India, and the USA. The project will generate important new insights into how public support for global environmental governance systems could be enhanced. It also connects two important but hitherto separate fields of research on collective goods, namely local common pool resources and global environmental governance, by examining whether and how specific sources of legitimacy differ in importance when governance systems,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Application of a Novel Magnesium-Lithium Dual Isotopic Tracer to Biogeochemical Cycles in the Soil Critical Zone' (ISOCRIT) targeting Seventh Framework.

assistant: **Abstract**

Chemical weathering exerts a key control on global CO2 cycles and ocean chemistry. Magnesium is a particularly important aspect of seawater chemistry, given that it controls the nature of carbonate precipitation is important tool in the reconstruction of past ocean temperatures. Stable isotopic tracers are increasingly being used to identify sources of Mg and other constituents in rivers and oceans and in marine sediments and sedimentary rocks to deduce paleoclimates, ancient ocean chemistry and circulation, and other aspects of Earth’s history. However these interpretations are entirely dependent on the processes that may fractionate the isotopes during mineral weathering and (bio)geochemical cycling.This proposal seeks to develop a novel biogeochemical multi-tracer using Mg and Li isotopes and apply it to test and interrogate the hypothesis that the isotopic composition of Mg in rivers is influenced by chemical weathering reactions in catchment soils. In particular, it seeks to understand processes in soils, the ultimate reactor in which the riverine flux to the oceans is determined. As an intensive case study, the isotopic multi-tracer technique will be applied to a large set of natural samples previously obtained from the Luquillo Mountains in Puerto Rico. This dataset will be used to demonstrate the potential of the multi-tracer technique and to move forward the models of biogeochemical mineral nutrient cycling that I am developing for the Luquillo Critical Zone Observatory (LCZO). The Mg-Li multi-tracer will also be applied on a global scale, by analyzing a large suite of soil samples from a variety of climates, latitudes, and rock types, which are currently archived by Professor Vance in Bristol.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'From Smart to Smartacular Built Environments: A Holistic Approach'.

assistant: **Innovation**

SMARTACULAR seeks to reimagine the future of the built environment by intertwining local vernacular insights with academic excellence. The project's heart lies in its ambition to shape built environments that harmoniously blend cutting-edge sustainability practices with local contexts' rich essence and soul. To this end, it poses an overarching research question: How can we design built environments that align with the pressing global sustainability demands while remaining contextually relevant? This is further broken down into three sub-questions that delve into the vernacular domain's contributions, translating these insights into practical guidelines, and understanding the challenges and opportunities of integrating these insights with current technological advancements.In pursuit of these objectives, SMARTACULAR employs a robust, interdisciplinary methodology, encompassing a blend of theoretical studies, grassroots-level participatory research, and qualitative analyses. The research journey is methodically structured into four key work packages that range from establishing a foundational understanding of global best practices to the hands-on piloting of devised tools in real-world scenarios. At its core, SMARTACULAR is dedicated to crafting a qualitative matrix tool – a blueprint that empowers developers to tailor designs to both global sustainability imperatives and local sensibilities. This approach promises structures that are 'smart' in function and deeply resonant with the essence of their locales. Underpinning the project is an inclusive dialogue platform, bridging diverse disciplines and championing collaborative efforts to ensure holistic and impactful results. The resulting tool is envisioned as an open-source tool, poised to spark further innovation, explo