RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Uncovering the mechanisms of action of an antiviral bacterium' (Mechano-Wolbachia) targeting Horizon Europe.

assistant: **Abstract**

Animals and microbes interact in intricate ways. Wolbachia, a common intracellular insect symbiont, can manipulate reproduction and protect hosts from viruses. Thus, Wolbachia is an asset in the control of insect-borne diseases. However, as Wolbachia cannot be cultured outside of host cells or genetically manipulated, the mechanisms of its antiviral phenotype remain poorly understood, and this inhibits wider exploitation.I have been working to remedy these deficiencies, and now stand poised to discover the mechanisms of Wolbachia-conferred antiviral protection by answering the following questions:1) Where does the protection originate? Up to now, mechanisms of protection have been studied in whole organisms, often lacking resolution, or in cultured cells, which lack emergent properties. I will identify tissues and cell types of the host where protection starts. To do this, I will: a) quantify titers of Wolbachia and virus at early time points post-viral infection in insect tissues, b) measure gene expression of host and microbes to identify candidates for further molecular characterisation, and c) test the extent of the utility of widely adopted, yet unvalidated, cell-culture models of antiviral protection.2) Which Wolbachia genes effect protection? Wolbachia research has historically been impeded by a lack of tools to study gene function. Here, I will deploy antisense technology, which I have recently developed, to interrogate function of candidate Wolbachia genes in the native system. I will also engineer new methods to target Wolbachia genes and proteins, based on my data on cell-penetrating peptide-mediated delivery of bioactive cargo to Wolbachia.This project has two major outcomes: it will uncover Wolbachia factors responsible for Wolbachia-conferred antiviral pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cellular deoxynucleoside kinases as markers for cytotoxicity of nucleoside therapeutics' to be submitted under Fourth Framework.

assistant: **Abstract**

To determine the role of the four cellular deoxynucleoside kinases in the cytotoxicity of antiviral and anticancer nucleosides.To study the enzymology and molecular biology of the cellular deoxynucleoside kinases, particularly with respect to new nucleoside analogs.To establish reliable pre-clinical cell and animal models for the development of new chemotherapy's with higher efficacy and minimal toxic side effects.Deoxynucleoside kinases are required for the activation of nucleoside analogs used in chemotherapy. There are four deoxynucleoside specific kinases in animal cells i.e. cytosolic thymidine kinase (TK1) and deoxycytidine kinase (dCK) and mitochondrial thymidine kinase (TK2) and deoxyguanosine kinase (dGK). These enzymes have different specificity and are expressed at different levels in cells and tissues. Detailed characterization of the enzymatic properties of the four enzymes with purified recombinant enzymes will be done in case of TK1 and dCK. Crystallisation experiments with TK1 and dCK for structural determinations will be performed. A major goal of the project is to clone the genes for TK2 and dGK and to perform detailed biochemical and molecular biology studies with these enzymes.The expression of all four enzymes will be determined in tumors, drug treated and untreated normal and infected cells with selective enzyme assays, immunochemical methods and quantitative mRNA assays. There are important species differences in the substrate specificity of human and rodent dCK-the molecular basis for this differences will be investigated. The role of the four kinases in deoxynucleoside metabolism will be tested by selection and construction of cell culture, organelle (e.g. isolated synaptosomes) and animal model systems where one or several of the enzyme functio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Design of systems to allow shellfish producers and traders to hold stock in algal toxin free water' to be submitted under Fifth Framework.

assistant: **Abstract**

To address the problem of bay closures due to Harmful Algal Blooms (HAB) and the resultant loss of revenue to fish farms as well as the loss of product on the market.This proposal is intended to examine the feasibility of using naturally filtered sea water to:(1) Hold shellfish during an HAB,(2) Purify toxic shellfish,(3) Act as a bacterial depuration source.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'NEW THEORETICAL DEVELOPMENTS WITH APPLICATION IN THE AREA OF CYLINDRICAL MICROSTRIP ANTENNAS' in the context of a Seventh Framework call.

assistant: **Objectives**

Progress in practical implementation of conformal antennas has resulted in an ever-rising use of this type of antennas on aircrafts and spacecrafts as well as in flush mounted shipboards and in mobile communication systems. An accurate modeling of these applications requires new theoretical developments. Being much more complicated, the theory of cylindrical microstrip antennas is not developed up to the same level as planar microstrip antenna theory, and advancing this theory would give major advantages.The major goal of this project is to solve the most problematic points in the modern theory of cylindrically conformal antennas, namely, the need for efficient approaches to analyze a cylindrical microstrip antenna array whose size considerably exceeds the wavelength of operation (i.e., large arrays) and whose patches are of a complex shape. New and effective theoretical developments which include new physical ideas and concepts will be built to realize the analysis of a number of novel cylindrically conformal antenna arrays of a large electric size with patches of a complex shape.The expected outcomes will provide us with not only new theoretical knowledge but also with a new, powerful and flexible software tool useful for the design of a wide variety of realistic cylindrically conformal antenna systems, which are finding increasing applications in wireless communication. In particular, the results of this project can be used in the design of wireless networking mobile base stations with beam forming capability.The project will be delivered through an IIF (Dr Oleksandr Svezhentsev, experienced researcher > 10 years) from the Usikov Institute of Radiophysics and Electronics of the National Academy of Sciences of Ukraine (IRE NASU) to the Department of Electrical Enginee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Flow-aligned polarised Raman of biomacromolecular entities' under Seventh Framework.

assistant: **Concept**

Existing spectroscopic methods do not provide satisfactory data on structure, orientation and interactions of biomacromolecules in their native environments. This is especially true of membrane proteins, a major class of drug target. The structure of formulated glycoprotein biopharmaceuticals and their interactions with their targets are also a challenge for UV spectroscopies due to extremely high concentrations and the near invisibility of the sugars to UV radiation. Infra red methods suffer from water absorbance dominating the analyte signals. We will therefore develop a new technique called flow-aligned polarised Raman (FAPR) spectroscopy, which will have many of the advantages of existing techniques, including using aqueous environments, while avoiding their pitfalls by using visible radiation. We expect to gain new structural data on the studied molecules using FAPR. The applicability of this method will be verified on membrane peptides and proteins and glycoproteins.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Kinetics and phase coherence phenomena in trapped ultra-cold gases' (1998-2002).

assistant: **Innovation**

It is planned to investigate collective modes in trapped Bose gases and Fermi-Bose mixtures, the formation Kinetics and the phase and interference properties of large condensate as well as the attenuation of the phase fluctuation characteristics of these large condensed systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Co-operation platform for research and standards' under Sixth Framework.

assistant: **Concept**

COPRAS will survey FP6 IST projects for standards-related output and provide appropriate ones with information on standardization to help progress their outputs through standards bodies. Operating through successive calls, COPRAS will provide an ongoing platform for ICT standards/RTD issues and prepare generic information to improve standards awareness.The project is proposed by the European Standards Organizations CEN, CENELEC and ETSI, and by the Open Group and W3C, who, together with other major industry standards consortia, are members of the ICT Standards Board. ICTSB is the co-ordinating forum for European ICT standardization. It will be kept regularly informed of the project's progress and will discuss the emerging results to ensure that the project outputs are directed appropriately. A key objective of the IST programme is to ensure European leadership in the generic and applied technologies at the heart of the knowledge economy.The standards programme for eEurope will facilitate the adoption of the research results and provide feedback about their acceptance and problems in their use. COPRAS will thus act as an important link between the objectives of the IST FP6 programme and eEurope. COPRAS will establish action plans for chosen projects, including inputs to standardization, and either enable the participation of the project in existing standards groups or promote new standardization activities for consideration by ICTSB. It will also facilitate contributions to research by informing projects of the state of the art and which standardization activities are most relevant for them.Using inclusive consensus building mechanisms it can optimise SME participation. COPRAS will carry out additional promotional activities, including preparation of a set of web pages a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Smart Windows for Zero Energy Buildings', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Smart windows for zero energy buildings (SWEB) will rely on a variety of innovative smart windows (SW) solutions and products to meet the market growth potential and address the global environmental challenges faced by the EU to achieve and sustain zero energy buildings market. We propose the development of non-toxic, abundant, long-term functional SW materials (photochromic, thermochromic, electrochromic, transparent conducting), implemented in parallel with cost-effective, robust, and industrially scalable technologies for fabrication of low-cost thin-film SW and chromogenic devices with flexibility in design, such as photochromic, thermochromic, electrochromic and self-powered SW – the basis for zero energy buildings in smart cities. SWEB aims to recruit members of the ERA-Chair team that will bring complementary knowledge to the existing core team, thereby enhancing scientific excellence, increasing visibility, and bridging the gap between research to technology transfer. This will positively contribute to the achievement of Sustainable Development Goals, European targets for Clean Energy for all Europeans, the Smart Specialisation Strategy of Latvia, and contribute to the European Research Area. The short-term aim is to create a functional ERA Chair team that can implement the strategies defined in the scope of the ERA Chair, and ensure sustainability after the end of the project. The long-term goal of the SWEB is to strengthen the Thin Films Laboratory and the Institute of Solid State Physics in achieving high scientific and innovation results and enhance stakeholders’ networks. With the support of the ERA Chair, ISSP is planning to establish the Briefing Demo Centre for renewable energy in Latvia as well as the EU joint graduate school on SW and zero energy build
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Controlling leakage power in NanoCMOS SoCs' (CLEAN).

assistant: **Concept**

With the advent of nanometric devices, the relevance of leakage power has grown tremendously. All technology roadmaps, as well as the results from advanced semiconductor labs indicate leakage as the real showstopper for the future generations of nanoelectronic circuits if proper counter-measures will not be taken. To be successful, and thus leading to the capability of fabricating chips with sub-65nm technologies, such counter-measures must be rooted in the design domain, as process improvement will not be sufficient to cope with the increased leakage currents in MOSFETs. In other terms, time has come for considering leakage reduction also a design problem, and not only a technology problem.CLEAN will contribute in a decisive way to the solution of the problem of controlling leakage currents in CMOS designs below 65nm, which is of strategic importance in the ASIC and SoC design landscape. The RandD effort will crystallize around the development of new leakage models for nanometric technologies usable at different levels of abstraction, from device to behavioral, innovative circuit and architectural solutions for efficient leakage management, novel methods and prototype EDA tools for automatic leakage minimization. Such methods and tools will be integrated into commercial EDA frameworks, thus providing comprehensive solutions for power-driven design.The CLEAN Consortium features the right mix of competence (semiconductor vendors, EDA vendors, research institutes) and the appropriate mobilization of resources to guarantee the successful achievement of all the project objectives. Tight links to on-going European projects targeting advanced silicon technology development (e.g., the NanoCMOS IP and its possible successor, PullNano) will guarantee synergy and convergence of o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of hyphenated analytical chemical techniques and application to the study of reactive drug metabolites and normal and abnormal plasma lipoproteins' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The major objectives of this research project are to develop new and improve hyphenated techniques (e.g. LC-NMR-MS, CE-NMR-MS, CE-MS-MS) for the use in - investigation of reactive drug metabolites (drug allergy) - investigation of plasma proteins (diagnostic tool)The overall aim of the proposed RTD project is to further develop and apply hyphenated methods involving separation techniques [high-performance liquid chromatography (HPLC) and capillary electrophoresis (CE)] and nuclear magnetic resonance (NMR) and mass spectrometry (MS) for the study of i) reactive drug metabolites (in particular acyl glucuronides) in relation to their impact on drug allergy and other toxicological consequences and of ii) plasma lipoproteins in order to develop better instrumental techniques for use as diagnostic tools in relation to cardiovascular diseases and cancer. An important aim is also to establish a network for the training of researchers in the analytical chemical and adjacent techniques developed in this RTD project. The proposal gives the background for the two research areas in which we think our research will provide new knowledge. The new knowledge on hyphenation will be exploited by Bruker Analytische Messtechnik and will ultimately be published in international journals. The proposal describes how the objectives will be fulfilled by completing a number of task :1. Development of methods in HPLC-NMR (including chiral separations), micropore HPLC-NMR and CE-NMR2. Development of HPLC-NMR and CE-NMR methods for lipoprotein analysis.3. Analysis of lipoprotein and oxidised lipoprotein composition in normal and abnormal plasma by NMR.4. Synthesis of model and drug glucuronides.5. Use of 1H and l9F NMR and HPLC-NMR to derive transacylation kinetics.6. Quantitative structure-activity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Contribution of epigenetic mechanisms to the regulation of transcription during differentiation from the totipotent to the committed states', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Differentiated somatic cells derive from the same totipotent cell, they contain the same set of genes, and yet they are extremely diverse in morphology and functions.How expression of cell-type-specific genes is controlled during the progression from the totipotent embryonic stem (ES) cells to the fully committed cells of the haematopoietic lineages has not yet been studied in detail at early stages of development. Especially little is known about the epigenetic mechanisms that are associated with potentially active (permissive) states in totipotent ES cells and multipotent haematopoietic progenitors.The proposed work is expected to provide important insights into the epigenetic regulation of transcription during lineage commitment via the investigation of three developmental states:- totipotent (ES cells),- multipotent (haematopoietic progenitors), and- committed (differentiated cells).As a model system, the complete mouse lambda5-VpreB locus, containing two genes which are expressed in early stages of B cell commitment, will be characterised for epigenetic features that could contribute to the transition from inactive to active states during cell differentiation.These features are:- chromatin accessibility and nucleosome structure;- communication between cis-acting elements in the locus via physical contacts; and- binding profiles of locus-specific and general transcription factors.In addition to increasing our knowledge of the mechanism of gene regulation during cellular programming, the work could also improve our understanding of haematopoietic malignancies such as leukaemia.Part of the project will be achieved in collaboration with other European laboratories that may well raise the quality and attractiveness of the field as well as help establish a competitive in