RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'The integration of computer modelling, mould design & the liga process for micro-injection moulding of plastic parts'.

assistant: **Concept**

Industrial interest in micro fabrication techniques has mushroomed in the wake of recent advances in microtechnology, notably the LIGA technique, which provides a cheap and effective route to the mass fabrication of complex microstructures. At the heart of LIGA technology is the injection moulding process. It is generally accepted that computer aided modelling has superseded the trial and error methods that once characterised the design stage of injection moulding. Computer modelling is now relied upon to help design the mould, runners and gates, and to define and optimise a host of process parameters. However, current state of the art software has many drawbacks when applied to microinjection moulding, since the current 2D approach is fatally flawed when modelling structures, which have large surface to volume ratios. In addition, the small space and time scales governing the filling of micro structures strongly modify the physics of the flow.There is therefore a strong need for new and reliable models, together with improved physical knowledge of the process. The objectives of this project are: Development of a 3D mathematical and numerical model for the simulation of the filling stage of micro injection moulding; Acquisition of experimental evidence concerning the physical phenomena governing the process; Design of improved tools specifically targeted at micro injection moulding; Selection and analysis of engineering polymers for micro injection moulding; Assessment of the new integrated process using a complex industrial demonstrator micro part; Development of a completely new methodology to predict the quality of the parts. The consortium comprises a micromechanics institute (IMM), a university applied mechanics unit (UCL), an electronics components manufacturer (O
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A search for new interactions at Belle II using leptons' (InterLeptons) under Horizon 2020.

assistant: **Objectives**

Several measurements in the quark and in the lepton flavor sectors have shown anomalies with respect to the standard model expectations and are now referred to as flavor anomalies. The Belle II experiment at the Super-KEKB laboratory in Japan is collecting data by colliding beams of electrons and positrons. The aim of this proposal is to look for physics beyond the standard model at the Belle II experiment by a) searching for the direct production of new light particles, and b) looking for deviations from theoretical predictions when performing precision tests of the standard model. The team will analyse events with leptons and large missing energy in the final states and implement the most advanced analysis techniques including, for the first time, deep learning tools in the identification of signals at the Belle II experiment. First, we will search for invisible decays of a dark Z' boson, a hypothetical particle that might also explain the anomaly reported in the anomalous magnetic moment of the muon. Second, we will test with per mille precision lepton flavor universality by studying leptonic decays of the tau lepton and use the results to constrain new physics models such as those containing a lepton flavor violating Z' boson. Finally, we will search for new physics via lepton flavor violating decays of bottomonium resonances produced in initial state radiation events that, thanks also to an effective field theory approach, will allow us to interpret the search in terms of new physics mass scale and coupling constant, with an approach complementary to that of the LHC.


**Keywords:** New interactions, Z' boson, dark sector, lepton flavor (universality) violation, rare decays, bottomonium, B factory, flavor anomalies, new physics, tau lepton
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploring the biological significance of phenotypic heterogeneity in Pseudomonas' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Phenotypic heterogeneity – physical diversity amongst genetically identical individuals exposed to the same environmental conditions – is a phenomenon that has caught the interest of biologists for decades. Although recent technological advances have revolutionised our understanding of the mechanistic bases of phenotypic heterogeneity, its adaptive significance and associated biological function(s) remain largely obscure. Two hypotheses have been proffered: (i) the “bet hedging” hypothesis, which postulates that phenotypic heterogeneity is a risk-spreading strategy facilitating population survival in uncertain environments, and (ii) the “division of labour” hypothesis, which proposes that phenotypic heterogeneity can increase population efficiency by partitioning labour (or resources). However, despite great interest in this area, empirical evidence for the biological significance of phenotypic heterogeneity is severely lacking. Here, I propose a series of experiments that combine molecular genetics, state of the art single cell analysis techniques and metabolomics to directly test the biological significance of a recently characterised example of phenotypic heterogeneity: ON/OFF colanic acid capsule expression in the bacterial model system Pseudomonas fluorescens SBW25. By providing a direct, experimental test of hitherto theoretical hypotheses, the proposed experiments have the potential to provide some of the first empirical insight into why phenotypic heterogeneity is such a widespread phenomenon. In addition to being of academic interest, our results will have direct relevance for industries involved in the management of infectious microbes (public health, veterinary science and agriculture) and the use of microbes in product manufacture (biotechnology) and toxin b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Optimizing for Generalization in Machine Learning' (OPTGEN), addressing dissemination and exploitation.

assistant: **Impact**

Recent advances in the field of machine learning (ML) are revolutionizing an ever-growing variety of domains, ranging from statistical learning algorithms in computer vision and natural language processing all the way to reinforcement learning algorithms in autonomous driving and conversational AI.  However, many of these breakthroughs demonstrate phenomena that lack explanations, and sometimes even contradict conventional wisdom.  Perhaps the greatest mystery of modern ML---and arguably, one of the greatest mysteries of all of modern computer science---is the question of generalization: why do these immensely complex prediction rules successfully apply to future unseen instances?  Apart from the pure scientific curiosity it stimulates, I believe that this lack of understanding poses a significant obstacle to widening the applicability of ML to critical applications, like in healthcare or autonomous driving, where the cost of error is disastrous.  The broad goal of this project is to tackle the generalization mystery in the context of both statistical learning and reinforcement learning, focusing on optimization algorithms being the de facto contemporary standard in training learning models.  Our methodology points out to inherent shortcomings of widely accepted viewpoints with regard to generalization of optimization-based learning algorithms, and takes a crucially different approach that targets the optimization algorithm itself; building bottom-up from fundamental and tractable optimization models, we identify intrinsic properties and develop algorithmic methodologies that enable optimization to effectively generalize in modern statistical- and reinforcement-learning scenarios.  A successful outcome would not only lead to a timely and crucial shift in the way the res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'An unforgettable night for well-being with researchers of the Federative Universities of Basilicata, Molise and Puglia Regions in the Mediterranean Area""' in the context of a Seventh Framework call.

assistant: **Objectives**

UniFederLab will be animated by several different actions all focused on “Innovation and well-being” in important cities of the south part of Italy such as Bari, Foggia, Lecce, Brindisi, Barletta, Campobasso, Potenza and Matera. Events can be of different types: demonstrations, quizzes, games, exhibitions, shows, concerts, talk shows, competitions with prizes. A EU corner will be present in each location where people can find news, projects financed by EU, poster. The focus will be on research in the areas of nutrition, health and sustainability (food, clean energies, biodiversity, environment and neuroscience). All proposed events are designed in according to the tips logic (trendy, interactive, participative and sustained).""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Paris Agreement Overshooting – Reversibility, Climate Impacts and Adaptation Needs'.

assistant: **Objectives**

Overshooting the Paris Agreement temperature thresholds is a distinct possibility. The impacts of such overshoot scenarios would materialise globally, but be particularly consequential for vulnerable regions and systems for which thresholds of abrupt and possibly irreversible shifts or adaptation limits may be exceeded. A full consideration of impacts and adaptation needs under overshoot scenarios thus requires a risk threshold perspective integrating emission pathways, earth system feedbacks, regional to local impacts, and context-specific vulnerabilities. To address that challenge, PROVIDE will deliver highly innovative, integrative climate services that incorporate comprehensive information on impacts under overshoot pathways from the global to the regional and urban level, directly feeding into adaptation action. The project specifically aims to: 1) Produce global multi-scenario, multi-sectoral climate information which integrates and quantifies impacts across scales by means of novel climate and impact emulators; 2) Assess climate system uncertainties and feedbacks, and the (ir)reversibility of climate impacts to provide comprehensive risk assessments of overshooting; 3) Co-develop a generalisable overshoot proofing methodology for adaptation strategies to enhance adaptation action in response to overshoot risks; 4) Identify and prioritise overshoot adaptation needs in four highly complementary case study regions; 5) Integrate all project outcomes into a PROVIDE Climate Service Dashboard. The Dashboard will be designed to complement established climate service platforms and will be widely disseminated to foster uptake and sustainable use across all stakeholder groups addressed. The PROVIDE consortium is constituted of leading climate scientists as well as climate s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European Network for the Durable Exploitation of crop protection strategies' (ENDURE).

assistant: **Innovation**

The overall objective of ENDURE is to: (1) restructure European research and development effort on the use of plant protection products,  (2) establish the new entity as a world leader of development and implementation of durable pest control strategies. This will include a focus on rationalising and reducing pesticide inputs as well as on mitigating inherent risks through a greater exploitation of alternative technologies, and/or basing control strategies on a more cohesive knowledge of the ecology, behaviour and genetics of pest organisms.  The operational and structural objectives of ENDURE are:  [1] To overcome fragmentation in crop protection research and development within Europe through the design and implementation of a joint programme of research on crop protection as well as through the creation of a virtual crop-pest control laboratory  [2] To reinforce the R&D capacities needed in Europe to improve the basic understanding of the crop pest systems and develop durable pest control strategies  [3] T o progress towards a trans-national entity aimed at reducing pesticides inputs by encouraging durable integration of the leading European crop protection institutions, forming the nucleus of excellence around and from which institutions and researchers can integrate their activities  [4] To create a European centre of reference for supporting public policy-makers, regulatory bodies, stakeholders and extension services  [5] To increase mobility of researchers and co-operative use of facilities, equipment and t ools  [6] To ensure the spreading of excellence and support training to facilitate the adoption of safer and environmentally friendly crop protection approaches ENDURE brings together the leading crop protection institutions, the worldwide association of bi oco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Novel isotopic constraints on the environmental impact of continental flood basalt eruptions'.

assistant: **Innovation**

Continental flood basalt volcanism is characterised by the repeated eruption of huge batches of magma, producing enormous basaltic provinces over relatively brief intervals of time, and delivering large quantities of volcanic gas to the atmosphere. The release of gases and aerosols during CFB volcanism is thought to have had a significant impact on the atmosphere, ocean chemistry and climate – with such eruptions often linked with mass extinction events that punctuate the history of life on Earth.The environmental effects of flood basalt volcanism, in terms of atmospheric loading, is a function of the amount, rate and source of volatiles released by the eruption, as well as the mechanism of volatile delivery to the atmosphere. This research proposes a novel isotopic approach, specifically the application of the chalcophile zinc and copper stable isotope systems coupled with the radiogenic rhenium-osmium system, to quantify these criteria.The ultimate aim of this research is to constrain the environmental impact of atmospheric volatile input produced by individual continental flood basalt eruptions. This study will allow us to deduce whether a single eruptive event is enough to trigger biological crisis, or whether multiple eruptions are required to cause deleterious effects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Bridging continents across the sea: Multi-disciplinary perspectives on the emergence of long-distance maritime contacts in prehistory'.

assistant: **Objectives**

The role of the sea in drawing together peoples and cultures from distant places and continents in the historical period is readily apparent from textual sources and archaeological remains. In particular, and in contrast to the Atlantic, for example, which has served as a formidable natural barrier to east-west movement and migration, both the Indian Ocean and the Mediterranean have served as important zones of interaction and trade, across which populations have migrated and mixed for at least several thousand years. Recent research findings, including those from the applicant’s archaeological field project in south India, suggest that long-distance maritime activities in this region actually have quite precocious beginnings, and that important species and population transfers across the Indian Ocean probably began to occur well before the historical period. Such findings are perhaps not surprising in light of the evidence for human maritime activity dating back to the colonisation of Australia around 45,000 years ago, but they do suggest that the much more apparent historical evidence for maritime activity has biased maritime research in favour of later periods. This project will accordingly focus on the study of prehistoric maritime activity, and exploration of the specific developments that resulted in the transition from occasional seagoing to regular seafaring and then planned, long-distance voyaging. To do so, it will draw not only upon the traditional disciplines of archaeology and historical linguistics, but also the powerful new methods of molecular genetics, cladistics, and palaeoenvironmental studies. Such research is important not only for its value to researchers trying to reconstruct the histories of human populations, domesticated plants and animals, tec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Modification of single guide (sg) RNA in CRISPR-Cas9 gene editing Tool' (MsgRNA) targeting Horizon 2020.

assistant: **Abstract**

CRISPR/Cas9 has been extensively studied for genome editing, but its therapeutic application has been hampered by off-target effects. Site-specific modification of single guide (sg) RNA in CRISPR system is a potential means to expand the utility of CRISPR-Cas genome editing. To address this, and reduce of synthetic burden of sgRNA we propose a ‘click’ ligation method to synthesize sgRNA where two chemically modified oligonucleotides are joined together using CuAAC chemistry. The resultant artificial linkage is biomimetic, so it should not affect Cas9 activity. This method offers significantly higher DNA-targeting specificity (i.e. less off-target effects) and most importantly provides a cost-effective means to access thousands of synthetic sgRNAs. Imaging in CRISPR-Cas9 system using fluorescence in situ hybridisation (FISH) probes have enabled significant advancements in understanding genomic structure and transcriptional control. We will explore novel approaches to image CRISPR-Cas9 system using fluorophore-quencher pairs. The activation of fluorescence can be performed upon nuclear localisation using RNase H, and upon sgRNA binding to the target DNA. These methods will provide highly fluorescent sgRNAs for live-cell imaging, potentially much brighter compared to other methods. To control CRISPR off-target effects we will also design a light induced DNA damage method where cyanovinylcarbazole nucleoside or psolaren will be incorporated in the DNA-targeting RNA. Therefore, modification of sgRNA for CRISPR system can be used to address the biological limitations of CRISPR and expand its functionality. This will open up many avenues for future development and lead to more application-focused studies on therapeutic gene editing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Effects of environmental and habitat characteristics on condition and reproduction of exploited marine fish populations' under Sixth Framework.

assistant: **Concept**

Despite evidence of important ecological linkages between habitat and fishery production, the management of most commercial resources world-wide has historically concentrated on assessing stock size and controlling fishing mortality. In addition, biologica l processes such as fish condition, fecundity and maturity, which are important features of future population success, are not commonly used to evaluate the quality of fish habitats, and are not taken into account by the current assessment methodologies of exploited fish. This project addresses new fields in fisheries biology and management, which move towards ecosystem-based approaches that strive to study and protect habitats vital to self-sustaining populations of living resources, and towards the consid eration of fish physiology in fisheries assessment. Firstly, this re-integration project aims to analyse the influence of productive and structurally complex habitats (e.g. submarine canyons, the continental slope and areas influenced by river runoff) on t he condition and reproductive potential of two exploited fish species. The use of fish condition to evaluate the quality of fish habitat aims to provide useful information on which fisheries managers could base decisions about the timing and location of ma rine protected areas, and to detect reserve effects on fish populations. Secondly, this projects aims to explore the utilisation of fish condition as an explanatory variable of reproductive potential, in order to improve future stocks assessments. These st udies constitute a promising research field to help management and preservation of fishery resources, fish habitats and marine biodiversity. The proposal addresses research fields included in the FP6-thematic priority 6, which are important to management o f