RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Better Experimental Screening and Treatment for Primary Ciliary Dyskinesia' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Primary Ciliary Dyskinesia (PCD) is a rare genetically heterogeneous disorder which results from dysfunction of motile hair-like organelles (cilia) that results in severe, chronic airways disease. Due to other cilia-related disease mechanisms several other organ systems like the heart can be affected. The complexity of the disease phenotype, late diagnosis, as well as lack of evidence based management guidelines contribute to a high burden of disease and cause high health care costs.Therefore, there is a great need for observational trials as well as well-designed randomised controlled trials to put evidence-based diagnostic and treatment approaches into effect.The main objective of our project is to improve diagnosis and treatment of PCD patients. To accomplish this, we propose to:1) Establish widespread, early diagnosis by introduction of nasal Nitric Oxide measurement as screening tool, and by introduction of high-speed videomicroscopy as diagnostic tool;2) Develop new outcome criteria, especially a PCD-specific quality of life questionnaire, as a prerequisite for controlled PCD trials;3) Establish a PCD registry for both cross-sectional analysis of current disease status and longitudinal observational analysis of disease progression under different regimens;4) Generate evidence-based treatment guidelines by conducting two prospective randomized trials on the inhalation of hypertonic saline and long term azithromycin therapy.To achieve these goals members of the European Respiratory Society’s PCD task force will join forces with members of the NIH-funded US-PCD-network.In our multi-national project, we will for the first time establish evidence-based guidelines for diagnosis, clinical management and therapy. We expect that in a high proportion of children the diagnos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Low background techniques on particle detectors for Rare Event Searches' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The nature of the Dark Matter (DM) is one of major open questions in modern physics with two interesting candidates: axions and Weakly Interacting Massive Particles (WIMPs). Axions arise from extensions of the Standard Model (SM) implementing the Peccei-Quinn mechanism. On the other hand, WIMPs appear in well-motivated extensions of the SM, like supersymmetry. Axions and WIMPs could have been produced in an early stage of the Universe and have been extensively searched during last decades.The use of Micromegas (MICROMesh GAs Structure) readouts has been recently introduced for axion and WIMPs searches and proposed for different experiments: TREX-DM and IAXO. TREX-DM is located in the Canfranc Underground Laboratory and is looking for low-mass WIMPs, in a mass range that is attracting the interest of the experiments. On the other hand, IAXO is a proposed new generation solar axion helioscope with enhanced sensitivity. The low counting rates expected in these experiments require to bring down the experimental background to the lowest levels possible. Another important aspect to enhance the physics potential is to reduce the low energy threshold, that would increase TREX-DM sensitivity to even lower WIMP masses. Moreover, it would make IAXO sensitive to axion-electron coupling values.The goal of this proposal is to reduce the background levels in order to reach sensitivity scenarios with discovery potential for axions and low-mass WIMPs and secondarily to reduce the low energy threshold. These objectives can be achieved by the use of some innovative aspects like the introduction of new Micromegas architectures and the use of new radiopure electronics. If the objectives are fulfilled, the advancements in the field would be tremendous, it will set the baseline for the design
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hazardous waste treatment and valuable products recovered with a pulsed-plasma technology' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Objectives and content Material cracking or decomposition is a basic and essential process in the chemical industries This process is a major energy consumer and a cause of environmental pollution. As such, it is in the focus of permanent research efforts in order to reduce both energy costs and hazards. The challenge we face is to provide an economical and efficient decomposition method for fluid materials that can be implemented on the manufacturing lines within the plants. It is aimed to reduce the energy consumption, to avoid the production of pollutants, and eventually eliminate the need to transport hazardous waste from the plants to treatment centres. The proposed process combines the benefit of a cost effective and environmentally favourable method. The market consists of industries such as petrochemical, plastic, pesticides, electronics, paints and coatings etc., include hazardous organic compounds in their processes either as a raw material or product or intermediate agent. VOC (Volatile Organic Compounds) halogenated organic materials, phosphorous compounds are a good example for the utilisation of the proposed method. The most common treatment method for these materials is thermal incineration. For example, 1995, 36.8% of the VOC in Europe were incinerated at the cost of M$138.2 and the market is steadily increasing. The hazardous waste treatment market in Europe exceeds 1 billion ECU/year. The aims of this RTD project are to develop a new, efficient and environmentally friendly processing technique and equipment that can be used in a closed-loop process for the recovery of materials. The proposed process is based on emerging science and advanced chemical engineering technology that may achieve stepchange decrease in pollution. The method could also be used
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Analysis of early HIV-1 induced changes in host gene expression following infection of primary cells', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Human immunodeficiency virus type 1 (HIV-1) infection induces the depletion of the CD4-positive T cells in infected persons, leading to AIDS. The currently available treatments for HIV-1 infection do not cure the infection, display many side effects, lead to drug resistance, and are expensive. Consequently, there is a real need to further define the cell host/virus interactions that are either required for viral replication, or are capable of controlling infection. Little is known regarding the changes in cellular gene and microRNA expression that occur in host cells in response to HIV-1 infection. I propose to conduct detailed, time-dependent genome wide analyses of human gene expression in primary cells following HIV-1 infection, by using a combination of micro-arrays and deep sequencing methods. This study will be conducted in primary blood cells (the natural targets of HIV-1 infection) such as resting or activated CD4-positive T cells, monocyte-derived macrophages and monocytes. Reverse transcription in combination with quantitative real-time PCR will be used to validate observed changes in host gene expression. I plan to identify both the viral determinants and the cellular signal transduction pathways responsible for altered gene expression. Finally, I will analyse the functional relevance of the mRNAs and microRNAs induced, with respect to the potential control or suppression of HIV-1 infection. This work will provide new information on the interactions between HIV-1 and infected cells, on the ability of host cells to respond rapidly to virus infection, and on mechanisms of cell-mediated resistance to infection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Probing how value comes to matter in the energy transition: Good-by-Devicing?' (Good-by-Devicing).

assistant: **Concept**

While the climate crisis accentuates the need to decouple economies from fossil fuels, local opposition in Europe increasingly delays the transition to renewable energy. Arguing that the energy transition has been organised as an expert issue pursued by design tools based in techno-economic valuation, Good-by-Devicing proposes that resistance to renewable energy cannot be solved when opposition has already solidified in the phase of project planning and development. Instead, this project seeks to accommodate broader social concerns over the impacts of the energy transition much earlier, by inquiring into the design phase where experts develop and use critical design tools such as energy scenarios, digital simulations, and procurement schemes. These devices incorporate expert decisions on what concerns to include and exclude in the design of the energy transition. Hypothesising that rising opposition has roots in colliding valuations of the value of energy transition and what concerns should be accounted for in devices, Good-by-Devicing probes a position where renewable energy can be deployed with sufficient pace, but where broader social values are encompassed in the design tools that shape our energy future. To shed light on how value comes to matter in the energy transition, the project uses the case of the contested development of the world's first 'energy islands' in Denmark.  The natural island of Bornholm is used as a strategic research site to ask how the energy transition could be valued otherwise, encompassing broader social concerns. Combining perspectives in Science & Technology Studies of Valuation Studies and the Sociology of Expertise, the project provides a new understanding of local opposition to renewables, contributing to the Social Acceptance literatu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New blow-out preventer/wireline stuffing box for the oil and gas industry' (1994-1998).

assistant: **Innovation**

Numerous well control problems occurring over several decades have been studied to determine the causes. By learning from these past well control mistakes, we can help prevent future blowouts. Currently many leakages and accidents occur at the boreholes drilled in the production of hydrocarbons. These have disastrous consequences for both the environment and the personnel involved. This new device is proposed as a solution to assist in the safe control and management of wellheads. The application of such a device within this highly pressurised environment, will prevent the escape of fluids, rod and wire rope whilst permitting drilling operations to be continued and adjusted accordingly. Ultimately, this revolutionary system will ensure the elimination of blow-outs. It offers not only greater safety and more control, but also significant cost and damage reduction for both the offshore industry and the environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Simulating adaptation of forest management to changing climate and disturbance regimes' under Seventh Framework.

assistant: **Concept**

Forest disturbance regimes have intensified distinctly in recent decades, and climate change is expected to further increase the frequency and severity of disturbance events. Adaptation is thus necessary to mitigate detrimental effects of this intensification on the sustainable provisioning of ecosystem services. However, while we’re beginning to understand the responses of individual disturbance agents to a changing climate, our knowledge on disturbance regimes (i.e. multiple agents interacting in space and time) is still limited. The development of adaptation strategies is further complicated by remaining deficiencies in our conception of forests as coupled human and natural systems. While forest models are increasingly able to simulate climate change impacts dynamically, human responses to these ecosystem changes are still widely represented as static prescriptions in such models, neglecting the adaptive capacity in silviculture. The here presented research agenda addresses these issues, with the overall aim to foster adaptation to changing climate and disturbance regimes in forest management. We will study wind – bark beetle interactions based on empirical data from long-term ecosystem research, and implement such interactions into a novel forest landscape simulator. We will furthermore develop an agent-based model of forest management within this simulation framework, with the ability to adapt management dynamically to the conditions emerging from the simulation. Harnessing these methodological advances in a number of case studies we will address questions such as whether interactions will amplify the climate sensitivity of disturbance regimes further, and how response diversity in multi-owner landscapes affects adaptive capacity. The project aims at improving the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'GridEye Scalable Transactive Distribution Systems'.

assistant: **Objectives**

Coordination of different players in active distribution systems by increasing the penetration of distributed energy resources and rapid advances on the aggregators, microgrids and prosumers with private territory individuals establishes new challenges in control and management systems from the owners’ point of views. Undertaking digitalization of future distribution systems, GiSTDS introduces an edge computing framework based on GridEye, the core production of DEPsys, which provides real time visibility and monitoring. Relevant drawbacks in the distribution system management platforms in handling the scalability of players, look ahead preventive management systems regarding contingency condition and lack of physical boundaries for third party entities (aggregators) will be addressed by GiSTDS.  The main novelties of this project in comparison to the GridEye are:  1)  Developed P2P trading module provides automated double auction negotiation in real time fashion which enables all private entities with and without specific physical boundaries to participate in local and flexible electricity markets. 2) Modification of GridEye’s modules to address the scalability and resilient operation in both the normal and contingency conditions.  3) To present a look ahead energy managements schemes for the operators, GiSTDS will be equipped to the forecasting module based on auto-regressive with exogenous variables (ARX) and machine learning techniques such as long short term memory (LSTM) and recursive neural network (RNN). Therefore, GiSTDS based on modified and developed modules explores comprehensive distributed framework for control, monitoring and operation of energy systems with multiple dispersed players in different scales. The edge computing solutions in GiSTDS eectively di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Spatial machine-learning analysis of child indicators'.

assistant: **Innovation**

Horizon Europe seeks to achieve the UN’s Sustainable Development Goals (SDGs). The WHO–UNICEF–Lancet Commission suggests placing children at the center of the SDGs, because children are among the world’s most vulnerable and marginalized population. Child indicators calculated with surveys are limited because surveys can be outdated and do not cover all the regions of a country. In this context, the objective of the project is to develop a methodology to overcome this limitation and identify vulnerable young children in countries with outdated, incomplete, and low-quality survey information. The methodology is based on a spatial machine-learning analysis of child indicators and integrates 3 disciplines: child development, spatial analysis of satellite images, and machine-learning. Satellite images and households’ simulations will complement the missing or outdated information of surveys, and machine learning will identify children that could be left behind during the development process due to the intersectionality of gender with biological diversities, ethnicity, socio-economic status, and geographical location. The project will create new tools for monitoring the progress towards the SDGs and will help to formulate targeted interventions that increase the social impact and reduce the economic costs of poverty-reduction and development programs. If the project is funded, Dr. Rolando Gonzales Martinez will carry out the fellowship at the University of Groningen, under the supervision of Prof. Dr. Hinke Haisma and with support from Prof. Dr. Dimitris Ballas. A short visit to UNICEF is planned as a secondment for Dr. Gonzales Martinez, so he can work with UNICEF on improving the policy impact of the project. The transfer of knowledge between the research fellow and the hos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Awareness services and systems-towards theory and realisation' (ASTRA), addressing dissemination and exploitation.

assistant: **Impact**

Awareness systems are a class of computer mediated communication systems that help individuals or groups build and maintain a peripheral awareness of each other. Current research into awareness systems for leisure and social use is characterized by a proliferation of point solutions that are created by designers or researchers and then handed down to users. Without a way of interpreting and predicting the success or failure of such systems in providing value to their users, this process tend to be an ineffective and expensive way of addressing users needs that stifles innovation, and fails to exploit the potential of awareness systems as a driver for connecting people.The project will explore awareness systems supporting the concept of pervasive awareness, i.e., where awareness information is automatically generated as a result of personal and home devices capturing and exchanging information about the user semi-autonomously. The ASTRA project has a theoretical and a technology development goal. ASTRA shall create a theoretical account of the benefits these systems can provide, addressing the shortcomings of current media theories in interpreting, predicting and even helping attain the acceptance of awareness systems for informal social communication. It will also create an experimental infrastructure: A service oriented architecture and tools for enabling end-user communities to create their own awareness systems and services.The project shall support, facilitate and analyze the process of innovation driven by end-user communities who will act as designers and programmers of their own awareness services. In doing so, awareness systems can be made to fit the idiosyncratic needs of different communities, relevant to their own particular life-styles, culture and communica