RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Machine Learning-Assisted simulation of Metalloenzyme’s Reactivity' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Metalloenzymes play a crucial role in various biological functions, going from small molecule transportation to catalyzing essential metabolic ingredients. Understanding their reactivity is essential for advancing a broad range of fields and related industries, such as medicine, biotechnology, environmental science, and catalysis. The computational modelling of biomolecules is a pillar of new drug and catalyst design, but the common methods used for purely organic-based compounds, such as empirical force fields, cannot simply be applied in the presence of a metal centre due to their complex electronic structure. On the other hand, hybrid Quantum Mechanical/Molecular Mechanics (QM/MM) methods provide a way to study metalloenzymes, but their computational overheads prevent their large-scale use for molecular dynamics simulations and reactivity studies. The project MAchine Learning-Assisted simulation of MEtalloenzyme’s Reactivity (MALAMER), aims to revolutionize the simulation of metalloenzymes' reactivity by integrating machine-learning force fields with QM/MM methods, and advanced sampling techniques, allowing for an unprecedentedly accurate description of their activity. This innovative approach will lead to significant insights and applications in catalyst development and drug discovery, with a potential impact on several EU priority areas. The project will commence in September 2024 under the supervision of Prof. Lunghi at Trinity College Dublin, with a planned 3-month secondment at University College London to gain additional expertise in advanced sampling simulations from Prof. Salvalaglio. A comprehensive set of training, dissemination, exploitation, and communication activities are planned and they will be implemented with the help of the supervisors and Trinity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Illuminating the dark side of surface meteorology: creating a novel framework to explain atmospheric transport and turbulent mixing in the weak-wind boundary layer'.

assistant: **Objectives**

Surface meteorology impacts the abundance and quality of life on Earth through the transfer and mixing of light, heat, water, CO2, and other substances controlling the resources for humans, plants, and animals. However, current theories and models fail when airflows and turbulence are weak during calm nights leaving weather and climate forecasts uncertain. This ‘dark side’ occupies substantial fractions of time and our landscape, its physics are largely unknown, and has eluded proper experimental investigation.DarkMix creates technological and theoretical innovations to observe and explain transport and mixing in the weak-wind boundary layer. Its ambitious goal is a radically new framework incorporating unexplored mechanisms such as submeso-scale motions, flow instationarities, and directional shear to effect a quantum leap in understanding the air-plant-soil exchange. DarkMix will build the ground-breaking first-ever fiber-optic distributed temperature sensing harp to fully resolve the 3-dimensional flow and air temperature fields and enable unprecedented computation of eddy covariance fluxes at scales of seconds over 4 orders of magnitude (deci- to hundreds of meters). Both key innovations bear significant risks of technical and fundamental nature, which are mitigated by pursuing alternatives. Measurements will inform cutting-edge large eddy simulations to test hypotheses. The interdisciplinary dimension takes DarkMix to a unique set of weak-wind sites including a valley-bottom grassland, a forest in complex terrain, and a city to investigate topographic effects, the forest carbon cycle, and the urban heat island.DarkMix will open a new window for surface meteorology and its links to air quality, biogeochemistry, and climate change by giving physically meaningful and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Towards integrating virtual reality and optimisation techniques in a new generation of Networked businesses in Warehouse Management Systems under constraints' in the context of a Sixth Framework call.

assistant: **Objectives**

Warehouse Management System (WMS) mission is evolving from controlling goods movement and storage to light manufacturing, transportation and order management. Demands from manufacturer end users are asking for WMS solution with decision making applications and networked environment. The Net-WMS project proposes a software solution enabling the expected new generation of Networked businesses WMS. Net-WMS will handle networked communication and co-operation processes through the integration of decision-making technologies, generic 3D placement primitives, virtual reality for 3D visualisation, interactivity to design packing models, knowledge modelling. The added-value and competitiveness increase of the Net-WMS solution will be characterised by shared expertise, easy deployment and maintenance, flexibility, interoperability, better resource handling and access to remote services.The Net-WMS achieved prototype applications for processes in a networked WMS will include:- A packing modeller of items based on virtual reality and optimisation techniques.- A palletiser tool using optimisation techniques.- A dispatcher with the virtualisation of a truck load.- A set of interfaces will enable Net-WMS communication between several planning components across a network.Net-WMS generated knowledge will be shared in networked warehouses, thanks to its interoperability and user friendly interface designed for plant level technician users.Net-WMS optimisation developments will also be made available for the whole community through the enhancement of the Choco open-source system. The achieved optimisation technologies will enable 20% saving for packaging costs. The project gathers nine European organisations having a recognised expertise in logistical and packing problems as well as soft
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Embedded systems Service-based Control for Open manufacturing and Process automation' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

E-SCOP project is built under ARTEMIS Sub-programme 4: Embedded systems for manufacturing and process automation. The project aims to overcome the current drawbacks for the shop floor control level (i.e. MES and deterministic / real-time control), thus improving the state of the art of the overall production control system architecture. This goal is achieved by introducing an innovative approach based on the combination of 3 different pillars, namely: i) embedded systems, ii) ontology-based knowledge management and iii) service-oriented architecture. The approach is called Open, Knowledge-Driven Manufacturing Execution System (OKD-MES).Traditionally embedded devices have limited resources in terms of memory and processing (CPU) capabilities. However the development of communication technologies made it possible and affordable to integrate heterogeneous devices into a large networks as it become possible to implement on embedded devices different protocols stacks developed by World Wide Web Consortium (W3C). This includes web services protocols. A number of European and national projects have already demonstrated how to use web services at the level of embedded devices in the field of manufacturing. However, the integrated approach for manufacturing system development that would focus on provisioning of missing and supporting services that operate together with embedded devices has still to be developed. One of the main results for E-SCOP project is a service-oriented middleware that should allow to build and simulate factory and process control systems.On general level, the proposed E-SCOP architecture is composed of three layers i) Physical layer, ii) Representation Layer and iii) Orchestration Layer.Approved by ARTEMIS-JU on 21/02/2013
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enzyme Design of Medical Interest', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Enzymes are the most efficient, specific and selective catalysts known up to date. Despite the enzyme advantages, not all synthetic processes present a natural enzyme to catalyze and accelerate the reactions. Hence, the design of new stable enzymes for those processes where no biocatalyst is known represents a major challenge for protein engineering and a stringent test to understand how natural enzymes work. In addition to that, the ability of designing specific active enzymes is of great interest due to the potential applications in biotechnology, biomedicine and industrial processes. In this proposal, the design of three enzymes of biological/medical interest will be fulfilled. First, an enzyme to reverse the formation of Advanced Glycation End-Products (AGEs), mainly associated to diabetes-related disorders, but also to Alzheimer’s disease will be designed. Second, the design of an enzyme presenting Glucose-6-Phosphate Dehydrogenase (G6PD) activity will be pursued. The latter might avoid the oxidative stress induced by many drugs in G6PD-deficient persons. Finally, the third objective of this proposal is the design of an enzyme with superoxide dismutase activity to avoid the oxidative stress produced in most of neurodegenerative diseases (i.e. Alzheimer’s, Parkinson’s, Huntington’s disorders). All designs will be performed following the research methodology developed by the Prof. Houk group which was already successfully applied for the design of active Kemp elimination and retro-aldolase enzymes. However, new QM/MM-MD strategies and DFT functionals developed at the return host organization (IQC) will be introduced to improve some parts of the design process. The fellow researcher will have the chance to work on this pioneer project in a world leading research group
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Quantification of the participation of soils in the microplastic pollution cycle and evidence based model analysis of atmosphere to ocean soil microplastic interaction' (PlastiSol) under Horizon 2020.

assistant: **Objectives**

There is little doubt that micro and nanoplastics (MnP) are in our soils across the globe. Numerous studies including my own have found that atmospheric deposition alone is enough to pollute even our most pristine remote areas. What is unknown is what happens to it once it is there. Is it transported by runoff or pushed deeper into the soil? What is the effect of the chemicals leached from MnP on soil microbiome, air and receiving river ecosystems? Many of these (e.g. flame retardants) are ‘forever chemicals’, never break down but continue to cycle in the food chain. What is the threshold before irreversible damage occurs, and have we pass it? These knowledge gaps have far reaching implications for food and water security and survival of the fragile ecosystems that make our planet habitable. PlastiSol seeks to address these urgent questions in an attempt to push the boundaries of our knowledge on this emerging threat. Through studying a cross section of land use soils MnP and associated leachates and the processes that contain or transport these pollutants, this project will advance MnP pollution science beyond considering soil as a sink, evidencing atmospheric and receiving waterway impacts of soil pollution. Furthermore, examining the internal mechanisms of soil MnP movement and leachate release will define the potential groundwater influence, land management activities and storage capacities of different land use soils’ MnP. With this evidenced process knowledge, the impact of soil MnP on the global MnP cycle will be established, enabling soil to be included as a source, transport pathway and sink of plastic pollution, advancing the accuracy of global MnP quantification and the impact of soil MnP on ecosystems and all environmental compartments. Only in understanding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Intelligent and reinforced tissue scaffolds for regenerative biomedicine' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Calcium phosphate ceramics have been used in medicine for more than 20 years because of its similarities to bone apatite. Bone repair and regeneration occurs along its surface and porous structures permits bone ingrowths acting as a scaffold in bony tissues sites. As well as these ceramics, bioactive glasses and biocompatible polymers are widely used but all of them present low strength and poor fatigue resistance to be implanted as high load bearing devices. In order to seek better ways of processing biomaterials, so that both mechanical properties and porosity could be optimized, devices have been design combining HA with other materials, however, significant amounts of the reinforcing phases are needed to achieve the desired properties, and as these parts are significantly less bioactive than HA, or bioreabsorble, the ability of the composite to form a stable interface is poor compared to HA itself. An ideal reinforcement material would impart mechanical integrity without diminishing its properties. This project envisages the use of carbon nanotubes (CNTs) as reinforcement material for the bioactive ceramics and to use their ability as drug delivery systems of pharmacological active molecules (osteogenic, antitumoral, antiviric,…) or as smart materials (able to change their properties as a function of the medium). In relation to this, the addition of CNTs to the base composite produces a three-dimensional electrical conducting network, property as has already been reported, could be used to provide electrical stimulation and increase of cellular proliferation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A new approach to design wireless receivers' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

While most analog functions have been taken over by their digital counterparts, radio receivers today are complex analog electronic circuits. They include amplifier circuits to provide amplification of the weak antenna signals. Ideally the amplifiers provide linear gain, but unfortunately the amplifiers exploiting transistors are inherently nonlinear, causing fundamental problems if large unwanted signals are received simultaneously with weak desired signals. This is why a radio receiver is a complex combination of many analog circuits: filters, mixers and amplifiers are placed between the antenna and the analog-to-digital converter (ADC), making receivers bulky, expensive and consume a lot of energy. The breakthrough concept of this program is to completely refrain from active linear amplifiers and thus have no active linear gain in a receiver. This way we avoid the fundamental problems in amplifiers and we minimize the analog hardware between the antenna and ADC, thus drastically simplifying the radio architecture. This program aims at connecting the ADC to the antenna, with just a separation by a so-called “N-path filter”. As pioneered amongst others by myself, N-path filters are simple structures without amplification and have recently become popular for wireless applications after being “forgotten” for many decades. Research work will focus on: 1) an N-path filter antenna interface, with extreme selectivity; 2) an ultra-low-noise ADC being able to convert the unamplified antenna signal; 3) a digital reflector to reflect unwanted signals arriving at the antenna; 4) precise timing circuits with far-beyond state-of-the-art timing accuracy to clock the N-path filter. I will focus on two different application areas: high-end receivers for high data rates in a crowded sp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular prospecting for novel bioactivities and understanding cellular proteolysis: Studies on proteases and unfoldases from hyperthermophilic Archaea' (PROTARC).

assistant: **Concept**

TET proteases, found recently in Archaea, are extremophilic enzymes that form large hollow molecular edifices (12 to 24 subunits) and process large substrates. However their function and activities remain poorly explored. Therefore, the project aims to characterise the enzymatic activity and the structure of these complexes with two objectives: I) specify their role into the cell, and II) explore their possible biotechnological use.The efforts of the project will be focused first in the enzymatic characterisation (conditions for activity, substrate specificity) of four recombinant TET-like proteases from the hyperthermophilic archaeal genus Pyrococcus. Then, a complete study about the structure of these enzymes will be carry out by using analytical ultra centrifugation, electron cryo-microscopy, crystallography and neutron scattering. These investigations will lead to understand the enzymatic mechanisms of the TET proteases and the molecular basis of their substrate specificity. Moreover, since the study is centred on enzymes that are stable and active at temperatures around 100°C, the results obtained could give place to new biotechnological applications. The second part of the project will focus on the cellular role of these proteases.Because of their complex quaternary structures and their co-purification with molecular chaperone complexes, the TET proteases could participate into the controlled elimination of proteins into the cytoplasm as partners of the 20S proteasome and/or by interacting with protein unfoldase complexes such as PAN. In order to specify this, protease assays will be performed in the presence of recombinant PAN complexes and/or purified 20S proteasome. Since the study of the archaeal systems can be a resource for solving the more intricate problem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Scallable COntroller for Power Sources' (SCOPS), addressing dissemination and exploitation.

assistant: **Impact**

To face the increased needs on current consumptions, some new technologies are introduced in power conversion stages (mainly owing to the introduction of GaN transistors).Few years ago, the Si Transistors as switches was the device limiting the performance and the market was dominated by US manufacturers in a monopoly for space application with high costs (need of specific design and foundries to face the radiation environment). This also lead to EU dependence to US export control restrictions. The introduction of GaN transistors allow to get better performances and also EU non dependence as some initiative promote European supply chain (as shown in H2020 EleGaNt on-going project). But now, the main integration & performance limitation is now the controller of the power stages available in the market :-Performance : limited switching frequency operation due to :oDevice technology : most of them in the market are in bipolar technology (slow & power consumption)oRadiation sensitivity : heavy ions can cause transients that are to be filtered (slowing down the performances)oPower consumption of the controller itselfFunctionality :Many functions are set owing to external parts (fine analog tuning, switching fThe SCOPS (Scalable Controller fOr Power Sources) This project sets one clear and measurable main objective:To design and evaluate the performance in space environment of Application Specific Integrated Circuit, nameds SCOPS, to control several power supply phases in parallel, using non-dependent supply chain.To do so, it is necessary that SCOPS provides the Space Community with:1.A flexible SCOPS Circuit that overcomes the limitations of existing controllers in terms of phase paralleling possibilities, performance, feature and radiation robustness.2.A fair commercializa