RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'RABIOPRED - Clinical validation of BIOmarker assay to PREDict treatment response in Rheumatoid Arthritis (RA) patients' (RA).

assistant: **Concept**

The aim of the RABIOPRED project is to take the final steps to bring an innovative set of biomarkers that is able to predict response to treatment with TNF-α inhibitors in Rheumatoid Arthritis (RA) to the market and clinical practice. Millions of RA patients are treated with TNF-α inhibiting agents, currently one of the main second-line treatment strategies for RA. These expensive biological RA therapies represent a multibillion market. However, the TNF-α inhibiting agents are not effective in 30-40% of the patients. Clinicians are currently unable to predict the response to this treatment beforehand. The ability to predict response to treatment would greatly improve clinical decision-making, improve health outcomes for RA patients, and contribute to cost reduction and sustainability of the health care system.The RABIOPRED assay is based on a novel gene expression signature and a predictive model, that have been identified and developed by TcLand Expression SA and that have been patented. Proof-of-concept has already been obtained for the prototype biomarker assay. The analytical validation and clinical performance evaluation of the RABIOPRED assay in the current project are the final development steps towards market introduction and clinical application. At the end of this 3.5 year project, a validated and CE registered IVD biomarker assay will be available that is ready for clinical application, initial market introduction and further commercialization and implementation.TcLand Expression SA is a French SME developing biomarkers for personalized medicine and companion diagnostics in immune mediated disorders. TcLand focusses on development and validation of noninvasive multi-gene molecular diagnostic blood tests. TcLand is embedded in an international network of colla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A novel mode of TGF-beta signalling through Smad1/Smad5 phosphorylation: mechanism and functional role in cancer', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Ligands of the Transfroming Growth Factor-beta (TGF-beta) superfamily control numerous cellular processes such as proliferation, apoptosis, differentiation, adhesion and mobility. As a result, it is well established that they play an essential role in cancer. TGF-beta signalling has been implicated in both tumour suppression and progression. TGF-beta signals predominantly through receptor-regulated Smads (R-Smads), Smad2 and Smad3, but several lines of evidence from the Hill’s lab suggest that TGF-beta can also strongly induce phosphorylation and consequently signalling by Smad1 and Smad5 in epithelial cells. Moreover, our recent results have shown that Smad1/5 activation by TGF-beta is not required for its growth inhibitory effects, but rather is specifically required for TGF-beta-induced anchorage-independent growth, suggesting a relevant role of this novel mode of signalling in tumor progression. The first aim of this project is the accurate molecular description of TGF-beta-induced activation of Smad1/5. We will focus both on the receptor complexes responsible and the types of Smad complexes that result. Then, we will study which genes are induced by this novel mode of TGF-beta signalling. Finally, its functional relevance in normal epithelial cells and in tumorigenesis will be assessed. If we can show that this novel branch of TGF-beta signalling plays a role in tumour growth, then it could provide a good therapeutic target in cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Biological magnets as a unifying link to multidisciplinary research excellence' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Latvia, one of the widening countries, has defined research excellence as an important aim for its higher education and research system. In the BioMagnetLink project, we will focus on biological magnets as a unifying link to multidisciplinary research excellence building upon the expertise of the ERA Chair. The ERA Chair has indeed an already proven track-record of high-level publications, an ability to attract, train and lead talents, to foster the mobility of researchers and the interdisciplinarity of research, and finally to coordinate international projects in the most ambitious research level. Forming the ERA Chair team at the University of Latvia to tackle a groundbreaking research related to microswimmer and magnetotactic bacteria to progress towards future personnalized medicine approaches. In addition, building on its experience, the ERA Chair will formulate precise and detailed recommendations on talent attraction, project preparation and execution, result dissemination, doctoral education and others, adapted to the institutional and national research environment, making them easy to implement. The support and interest from the university senior management will allow to materialize changes for the whole university. This will be of a great value due to multiple reforms currently taking place for the higher education level at the University of Latvia itself, but also more generally in Latvia.  To maximize the impact on the institutional environment, the ERA Chair will form a training group for local principal investigators, to help developing their leadership and writing skills. The positive effects on the largest research university in Latvia at the research, the training, and the structural level as shown by leading by example will promote systemic changes for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Pb-Free Perovskites for Efficient All-Solid-State Hybrid Solar Cells' to be submitted under Seventh Framework.

assistant: **Abstract**

Organo-lead halide perovskite absorbers offer an extremely promising solution to solar energy conversion, in line with the European Union’s 2020 renewable energy targets. This family of materials can be processed from solution utilizing common techniques and equipment developed by the printing industry, achieving power conversion efficiencies on par with the silicon industry. However, the state-of-the-art perovskite developed uses lead as the metal center, which is highly toxic and water soluble. This poses a serious environmental threat and a serious deterrent to the commercial development of this technology. Furthermore, in the usual processing scheme, toxic solvents such as DMF are used, which in combination with the carcinogenic lead salts employed make the production of these devices rather hazardous.This project seeks to address these issues via a novel solvothermal in situ bottom-up crystallization approach to form lead-free perovskite films from non-toxic solvents on a range of different substrates. The project has been designed with the idea of exploiting both the Fellow’s previous expertise in solid-state hybrid solar cell design and device physics and the Host’s expertise in the directed growth of ordered, metal-organic crystals. The expected developed devices will directly serve as commercial prototypes for the industrialization of this technology. The technology developed here will contribute to remove a significant hurdle (removal of a very toxic element) towards the implementation of an environmentally friendly alternative solar technology, thus enhancing European industrial competitiveness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nitrate Imbalance-control by TRAnsformative Technologies that are Electrochemically-driven' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Efficient management of nitrogen cycle imbalance is a critical need of this century. Water with elevated NO3- level is harmful to human and environmental health. Conventional treatment has limitations for point of use treatment and may generate sludge and/or brine solutions. Electrochemical processes are transformative chemical-free technologies that can reduce NO3- to innocuous N2 without sludge production. However, further research in efficient electrocatalysts and scale-up is required for technology implementation. In this project, research aims to overcome challenges of nitrate electrochemical remediation in three phases:  (i) nano-electrocatalyst synthesis and benchmarking, (ii) reactor design/construction and evaluation in actual water matrices, (iii) study of alternative electrocatalyst materials.First, different electrodic materials will be evaluated in terms of kinetic reduction and selectivity towards N2. I hypothesize that application of nanoparticle binary and tertiary Pt/Pd alloys with other metals (Cu, Sn, In) will lead to higher N2 selectivity and enhanced electrochemical reduction because the preferential performance characteristics of different metals combined into one electrode material. Use of nanoparticles in tridimensional modified electrodes will improve mass transfer towards/from electrode surface increasing treatment performance as well as reduce catalyst mass requirement. Second, design and construction of different electrochemical reactors for nitrate remediation will catalyze the development of electrochemical technology towards implementation. Reactors will be assessed from the treatment of actual water matrices (brine, groundwater, tap and surface water) and techno-economic analysis. Last, catalysts based on cheaper metal oxide semiconductor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Age-associated antigens in atherosclerosis immunity and immunotherapy'.

assistant: **Concept**

Cardiovascular disease remains the leading cause of mortality worldwide, with atherosclerosis (AT) as the primary underlying factor. Ageing is the strongest risk factor for both AT and CVD. Emerging evidence indicates that the B cell-mediated immune response plays a pivotal role in the development and progression of AT, although the nature of this response and its triggering antigens are poorly understood. In our prior research, we identified ALDH4A1 as novel AT antigen and showed that anti-ALDH4A1 A12 antibody is atheroprotective in mice. Our recent preliminary data show increased titers of anti-ALDH4A1 antibodies in aged mice as well as a rise in age-associated B cells in AT mice. These findings suggest a strong link between ageing, the B cell immune response, and AT. ANTI-ATHERO aims to functionally dissect the AT antibody response with the ultimate goal of identifying age-associated antigens that can serve as targets for specific immunotherapies. We will pursue the following aims: 1) characterize the early and aged B cell immune response in AT with time-stamping mouse models, 2) generate a single cell clonal atlas of time-stamped AT B cells and identify individual antibodies and antigens associated with the early and the aged AT antibody response, 3) translate our findings to human disease by mapping the B cell response in clinical AT and testing the identified antigens as markers of disease progression and, 4) evaluate the therapeutic potential of the identified antibodies and antigens through passive and active immunization strategies. We anticipate that the ANTI-ATHERO project will generate transformative insights into the interplay between ageing, the immune system, and AT. Our findings have the potential to significantly advance not only cardiovascular research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European Network for Durable Reinforcement and Rehabilitation Solutions' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The growth of advanced composites in construction in recent years has been spectacular, doubling in size in the last 10 years. This expansion has been largely due to the use of Fibre Reinforced Polymer reinforcement in structural applications and, although the current economic climate has seen a slowdown of the general construction market, the demand of composite products within the European construction market is estimated to grow and reach €3.1 billion by 2013.The on-going requirement for more durable structures and more efficient rehabilitation solutions is the key driving force behind the introduction of FRPs in the construction industry as reinforcing or strengthening material for concrete and masonry structures. In Europe alone, the annual cost of repair and maintenance of the infrastructure is estimated to be about 50% of the construction budget.Composite materials are readily used in a large number of applications and yet, a set of accepted design guidelines does not exist and most construction professionals are unaware of what composites are and rely on specialists who often use their own standards and guidelines.Moreover, little interaction exists between academia and industry and practical applications are time and again a reflection of a design approach instructed by conservative guidelines, which hinder innovation.The aim of the Network is to train researchers in the use of advanced composites for construction so as to develop and maintain a critical mass of research groups that will address the main scientific challenges in the field, enable the development of advanced material standards and design guidelines, co-ordinate European research, and offer a link between academia and industry.The Network will strengthen the European Research Area on composite re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A novel bioarchaeological approach to ancient textile manufacture'.

assistant: **Concept**

Textile manufacturing is one of the oldest crafting activities in human history, linking the use of natural resources and technological innovations to complex cultural and social processes. Despite the enormous economic importance of textile production, marred by its severe health impact, long-term perspectives on the history of this craft are elusive in the archaeological record, due to the perishable nature of the evidence it leaves behind, and the lack of specific and reliable skeletal markers of past occupations that would allow the osteoarchaeological identification of textile workers. AIRLOOM addresses these issues by investigating the human mouth and the respiratory tract as a ‘depositional environment’ where concentrations of textile fibres, dyes and other environmental particles can accumulate and preserve inside mineralised dental plaque (dental calculus) as a result of accidental ingestion and inhalation during manufacturing. AIRLOOM will employ cutting edge cross-disciplinary methods to skeletal collections and natural mummies from ancient Egypt, Sudan, and Lebanon (4000 BC-1000 AD). These regions are home to well-documented crafting traditions and technologies (metal, glass, textile, stone work, art), underpinning enormous inequality of living conditions for the labourers (today and in the past). AIRLOOM will integrate approaches from bioarchaeology, archaeological materials studies, ethnoarchaeology, experimental archaeology and environmental sciences to generate a novel multidisciplinary understanding of textile manufacturing in antiquity and its impact on health, with important direct implications for the practising of traditional textile work today. AIRLOOM is the first project of its kind in bioarchaeology, pushing current boundaries and establishing a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'International conference on soils under global change - a challenge for the 21st century' (1998-2002) under Fifth Framework.

assistant: **Objectives**

An Internat. Conference is proposed on recent development in soil and environment degradation processes, inducing a global change of these natural resources. Processes to be included in the Conference refer to: compaction, structure deterioration, erosion, contamination by various pollutants, desertification in arid and dry-sub humid areas, iridisation, periodic drought and water logging, climatic changes, etc. Scientists from various countries (especially EU members, candidates for accession to EU, Mediterranean partner countries, etc) will present the status of these processes in their own countries and results of recent research on available management farming techniques preventing mitigation and combating these processes. Conclusion will be widely dissemination and forwarded to decision makers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Quantum aspects of extended supersymmetric gauge theories' (QUANTUMSUPERSYMMETRY) targeting Seventh Framework.

assistant: **Abstract**

The project is aimed at the study of quantum aspects of extended supersymmetric field theories with various number of supersymmetries in three and four space-time dimensions. In particular we will develop extended superfield approaches to superconformal gauge theories with N=4 supersymmetry in four dimensional space-time and to supersymmetric Chern-Simons-matter theories with N=3,4,6,8 supersymmetries in three-dimensional space-time. Various classical and quantum aspects of these theories such as the construction of quantum effective action and computation of correlation functions of composite operators will be considered by using the developed extended superspace methods. These problems are motivated by the development of superstring / M-theory which is considered to be a candidate for the unified theory of all fundamental interactions of elementary particles. In particular, the four-dimensional N=4 supergauge theories effectively describe systems of D3 and M5 branes in supergravity and M-theory while three-dimensional N=6 and N=8 supergauge theories correspond to M-theory 2-branes. This gives rise to different manifestations of so-called AdS/CFT correspondence (or field theory / gravity correspondence). Within this project we will explore the properties of classical and quantum dynamics of above mentioned extended supersymmetric field theories that will shed new light on various aspects of the field theory / gravity correspondence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'EUROpean quality Controlled Harmonization Assuring Reproducible Monitoring and assessment of plastic pollution' (EUROqCHARM), addressing dissemination and exploitation.

assistant: **Impact**

Plastic pollution has become a global environmental and societal concern in recent years. Numerous protocols have been developed to monitor plastic debris, but these are rarely comparable. This has hindered gathering of knowledge regarding pollution sources, development of monitoring programmes and risk assessments and implementation of mitigation measures. To develop long-term solutions to reduce plastic pollution, it is essential to establish harmonised methodologies. EUROqCHARM will address this by critically reviewing state-of-the-art analytical methods and, taking harmonisation one step further, validating them through an interlaboratory comparison (ILC) study. This will bring together prominent laboratories in environmental plastics analysis and will produce certified reference materials to be marketed for at least three of the four target matrices (water, soil/sediment, biota, air), during and after project completion.EUROqCHARM recognises that harmonisation for large scale monitoring requires flexibility, comparability and reliability. We will identify Reproducible Analytical Pipelines (RAP), resulting in a catalogue of RAP procedures for nano-, micro- and macro-plastics for the four target matrices. Each RAP will be validated in terms of Technology Readiness Level to decide if further validation is needed (by ILC).Blueprints for standards, recommendations for policy and legislation and support for the establishment of acceptable reference levels and environmental targets will be given. This will include a roadmap for harmonised data collection and management, where policy analysis and coherence will be integral parts. To maximise impact, EUROqCHARM will also establish and consolidate an operational network for plastic monitoring, stimulating Transnational Joint