RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development and immunological control of dendritic cell cancer' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Dendritic cells (DC) are powerful antigen-presenting cells that can induce antigen-specific adaptive immunity to pathogens but also protective immunity against transformed self, i.e. cancer. This crucial role of DC makes them an attractive target in cancer vaccination. However, DC can also negatively regulate immunity by inducing antigen-specific tolerance and are a target in immunomodulatory approaches aimed at dampening autoimmunity or allergy. Given this dual role in immunity and tolerance it is hard to predict what would happen if DC were to become neoplastically transformed. Their immunogenic potential could make transformed DC highly susceptible to control by the immune system, which might explain why DC cancers are rarely observed in humans. In contrast, their tolerogenic potential could make transformed DC especially adept at escaping immunological control. So far, the aetiology of DC cancer and its immunological consequences remain elusive due to the lack of appropriate models to study the disease. In order to investigate the feasibility of DC tumour formation and the immune control of DC tumours, a novel genetically-engineered mouse model of DC cancer has been generated. We will use this model to characterise DC tumour development in vivo and establish which DC subsets contribute to DC cancer. Furthermore, we will adapt this model so that we can control the location and onset of neoplastic transformation of DC in vivo. Both models will then be employed to investigate to which extent DC cancer is recognised and modulated by cells of the immune system. Furthermore, we will assess whether transformed DC exploit tolerogenic mechanisms to progress into tumours. Our proposal will give novel insights into the biology of cancer development and its control by the immun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Impacts of marine xenobiotics on european commercial fish - Molecular effects and population responses.' in the context of a Fourth Framework call.

assistant: **Objectives**

The aim of this study is to produce a synthesis of the literature on the impacts of xenobiotics, from the biochemical to community level, in commercial fish and thereby develop a conceptual model with which to evaluate and assess the consequences of low-level pollution exposure on population and yield.This will be done by producing state of the art reports on ten thematic tasks examining individual aspects of pollution impact and their links to other levels of organisation. Through workshops and other communications, the results of the thematic reports will be synthesised into a coherent whole. Within each thematic task, the literature for European commercial and non-commercial fish will be synthesised. The outcomes of the project will be disseminated through the publication of thematic reports, a book, an international conference, a database of relevant literature and web-site.IntroductionExtensive work has been undertaken to examine the impact of a wide range of xenobiotics on various individual aspects of marine fish and invertebrate biochemistry, physiology and population structure (Bayne et al, 1988; Forlin et al, 1995). These studies have been performed throughout Europe and worldwide to resolve various objectives. They may have been performed to determine the toxicity of a specific chemical or compound to assess the potential hazard to individual species or ecosystems from the disposal of waste (Donkin and Widdows, 1986). They may have been developed to provide a rapid biomarker for pollution (Goksoyr et al, 1991; Depledge, 1993, Lawrence and Nicholson, 1998) or to act as bioassays of health, fitness, growth, under varied complex environmental parameters (Lawrence and Poulter, 1996, 1998). In some cases commercial fish and shellfish have been used, in others spec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'XUV-High Order Harmonic Metrology tools for novel Spectroscopic applications' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

We propose a project in the cutting edge research area of the generation, metrology and applications of the coherent XUV radiation of higher order harmonics and at to second (as) pulses (1atto=10~18), through which the successful transfer of knowledge from two major European Laser Laboratories (Saclay, MPQ) to a third one (IESL), is envisaged.The project that will be implemented in three tasks, incorporates the transfer of knowledge on issues of:i) high spectral resolution techniques for coherent XUV/EUV (Fourier Transform and Ramsey type spectroscopy) spectroscopie applications andii) the generation of intense isolated at to second pulses based on carrier frequency/envelope stabilized few cycle laser pulses.The proposed transfer of knowledge provides the framework and means in order to communicate and merge existing state of the art expertise in two partners laboratories with that of the host institution, aiming to achieve and exploit the integration of complementary techniques in a laboratory unit, that combines highest temporal and spectral resolution, at high intensities in the XUV/EUV spectral region. This leads to a significant improvement of there search capabilities of the host organization and is expected to strongly contribute in maintaining and further strengthening its sound international presence and competence, as well as to support its continuous efforts towards research improvement and new break throughs in a field in which research funding institutions of Europe invest and as a consequence European science is a world leader.The framework of the proposed project and its synergy with other related projects such as RT Networks, MC training sites and European Research Infrastructures, offers excellent training opportunities to experienced and promising youn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The evolution of post-orogenic landscapes: bedrock rivers, lithology and relief development' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Post-orogenic landscapes occupy by far and away the bulk of the Earth’s surface but their evolution remains under-researched and poorly understood, providing the central motivation for this proposal. The principal outcome will be the testing of competing models for post-orogenic landscape evolution. The proposal is strongly linked to studies that analyse how climatic and tectonic factors influence landscape evolution, and relies on leading-edge techniques such as cosmogenic nuclide analysis and DEM analyses; the work will have important implications for the parameterisation of numerical modelling of landscape evolution. The project will combine digital terrain analysis, long profile analysis and cosmogenic nuclide analysis in the 20,000 km2 Lachlan River catchment, a bedrock river catchment draining the inland (western) side of Australia's southeast highlands on the 90 Myr-old Tasman continental margin. The Lachlan drainage basin is a classic post-orogenic landscape that has a very well-constrained Cenozoic evolution. The aim of the proposal is to assess the key controls on the rate and style of landscape evolution in this typical post-orogenic setting (1) by quantifying rates of landscape evolution, and (2) by assessing the ways in which landscape evolution is slowed by resistant lithologies. Thus, the research will provide an assessment of one of the major neglected controls of post-orogenic landscape evolution, namely, lithology. The role of lithology in landscapes evolution lies at the heart of some of the enduring questions in geomorphology, such as: Do hard rocks slow landscape evolution, and if so, how do they do this? Providing answers to these questions using the most up-date-date techniques of cosmogenic nuclide analysis and DEM analyses will help to bring the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European integrated project on spinocerebellar ataxias (EUROSCA): Pathogenesis, genetics, animal models and therapy' to be submitted under Sixth Framework.

assistant: **Abstract**

Twenty two European groups from 9 countries with an excellent reputation of clinical, clinical-genetic and basic research on spinocerebellar ataxias (SCA) will jointly form an Integrated project to develop a treatment for patients suffering from this rare, late manifesting, and autosomal dominant inherited group of neurodegenerative diseases. To reach this goal, an international standard on the clinical evaluation in form of a Core Assessment Program for Interventional Therapies of SCA (CAPIT-SCA) will be developed based on clinical rating scales, structural imaging, and electrophysiology. The generation of the world largest collection of information on SCA, the European SCA Registry (EUROSCA-R), will ensure standardized data acquisition.This powerful tool will facilitate continuous recruitment of SCA patients throughout Europe for linkage analysis, identification of novel ataxia genes and natural history studies. The potential to include all larger European SCA families into linkage analysis will lead to the identification of new SCA loci and to the cloning of novel ataxia genes, respectively. Genotype-phenotype correlations will follow. Subsequently, for the first time such a combined effort will offer a systematic large-scale search for genetic modifier factors in SCA allowing a better comprehension of factors accounting for wide clinical variability with application for prognosis and to identify new potential targets (modifier genes). EUROSCA will also implement strong research projects to generate and characterize cellular and transgenic models, which will allow a more defined study of the pathogenesis and will serve as a tool for first therapeutic studies. 9 European research groups will be supported by five core facilities such as transgenic Drosophila work, Expr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Efficient millimetre broadband radio access for convergence and evolution' (EMBRACE).

assistant: **Concept**

The main objective of the EMBRACE project is to develop a low cost broadband wireless access system and services based on the results obtained during LMDS-trials under the ACTS program. In particular, inputs from users and operators regarding present and future access capacity demands and requirements for availability and quality of service will be used. The system will operate in the 40.5-42.5 GHz (43.5 GHz) bands and can easily be adopted for operation in other bands in the millimetre frequency range, allocated for this type of services. However, the indoor user's terminal can be used for a wide range of frequencies above about 20 GHz, suitable for broadband applications. In providing a low-cost fixed radio access technology all the benefits of the current Information Technology revolution will be delivered without requiring any broadband cable systems.Objectives:The main goal is to develop a low cost radio access system for the mass market. This will be achieved through efficient utilisation of radio frequency bands and optimisation of transmission capacities for a variety of users and usage. A prototype will be developed using MPEG-2 in the downlink and an uplink using multiple frequency time division multiple access. Time division duplex will be studied as an alternative to the frequency division duplex, realised in the hardware prototype. Star and mesh network allowing for network capacity growth as business grows, will be studied. The access network shall inter-operate and multiplex effectively with other common networks. Solutions allowing for nomadic users and route diversity (switching between two or more sase stations) will be developed. Planning tools that take into account obstruction from the topography and man-made structures, the effects of atmospheric p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Disconnect2Reconnect? Understanding Well-Being in an Increasingly Digital Society' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Mobile devices, and the ‘always on’ connectivity they enable via numerous social media services, are increasingly blamed for a decline in well-being among young people. In today’s ‘poly-social-media’ landscape where people often make use of multiple platforms for different purposes, the increasing pressure to check updates combined with an overload of information available can lead to increased emotional exhaustion and declines in physical health (e.g., sleep disturbance). Consequently, there is a growing trend of users desiring to disconnect from or to use social media more mindfully, but many struggle to do so effectively. While the idea of ‘digital detoxes’ is increasingly adverted in mainstream media and gaining public popularity, academic research is still in its infancy. This is problematic, as ‘social media fatigue’ – a state whereby people suffer from mental exhaustion after experiencing technological, informative and communicative overloads through their participation different social media platforms – might become a serious mental health issue due to the ubiquitous nature of mobile and social media. Fostering citizen’s digital competences and skills to effectively navigate digital society highly fits with the aims and scope of the European Commission’s 21st century ‘Digital Competence Framework’. Using a multi-method approach, combining mobile experience sampling methods and panel surveys, this action develops and tests a theory-driven model to explain the antecedents of social media fatigue, the strategies people use to disconnect from social media, and the short-term and long-term consequences for subjective well-being among young adults. The resulting Disconnect2Reconnect model advances theory and methods, offers actionable recommendations to practitioners
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Normothermic perfusion devices for renal and hepatic preservation and viability assessment' (NORMOPERF).

assistant: **Concept**

Organ transplantation is the best available technique for the treatment of end-stage failure of most essential organs. However, the further development of transplantation is being hampered by the scarcity of available organs and the limitations of static cold preservation: lack of information about the organ function and viability, ischemia-reperfusion injury, short preservation times and poor compatibility with suboptimal organs.Our solution to overcome these limitations consists in a portable medical device that is capable of maintaining the human kidney or liver in a viable state for sustained periods under physiological conditions ex vivo by means of a normothermic perfusion of the organ with a preservation solution that delivers oxygen, nutrients and chemical signals. Through maintaining the physiological cellular metabolism, it is possible to prolong the preservation times, reduce to a minimum ischemia-reperfusion injury, assess the organ viability and function by means of monitoring key parameters and increase the number of available organs.Our envisaged final solution consists in a product with three elements: the perfusion machine and two single-use consumables: the perfusion circuit and the preservation solution. Specific versions of the consumables will be available for each organ type (liver or kidney), but all of them will be compatible with the same perfusion machine. The product will address a global market, focusing initially on the EU and in a second phase on the USA.EBERS has a fully functional prototype of the device, validated and demonstrated using a porcine transplant model. In Phase 1 of the project, IP and regulatory strategies will be refined, the product concept will be validated, further market knowledge will be gained and the commercialisatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Start-up activities for Advanced Signalling and Automation Systems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

X2Rail-1 addresses the S2R-CFM-IP2-01-2015 “Start-up activities for Advanced Signalling and Automation System” call issued by the Shift2Rail Joint Undertaking as part of the Innovation Programme 2 “Advanced Traffic Management & Control Systems”.The X2Rail-1 project aims to research and develop six selected key technologies to foster innovations in the field of railway signalling and automation systems towards a flexible, real-time, intelligent traffic management and decision support system.The actions to be undertaken in the scope of X2Rail-1 are related to the following specific objectives: To overcome the limitations of the existing communication systems by adapting radio communication systems which establish the backbone for the next generation advanced rail automation systems. To improve the usable track capacity by introducing more Automatic Train Operation (ATO) systems and Moving Block systems. To innovate the signalling architectures towards more decentralized and less cost intensive systems by incorporating Moving Block systems and Smart Wayside Objects.  To minimize energy consumption and to improve train punctuality through more extensive use of Automatic Train Operation (ATO) systems. To increase innovation in the field of lab testing by developing architectures for new lab test systems and simulations for control, command and communication systems in order to reduce costs.  To ensure security among all connected signalling and control systems by developing new cyber security systems dedicated to railways. To ensure the backward compatibility of ERMTS/ETCS technologies, notwithstanding of the required functional enrichment of the future signalling and control systems.


**Keywords:** Shift2Rail, Innovation Programme 2, IP2, Control Systems, IP Communication,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Improved glioblastoma treatment through targeted, local drug delivery' under Horizon 2020.

assistant: **Concept**

The aim of this project is to develop a business plan to guide clinical development and commercialisation of SI053; a novel gel formulation for the treatment of the most common and aggressive type of brain cancer called glioblastoma. Glioblastoma affects approximately 2-3 people in every 100,000 each year in Europe and has an extremely poor prognosis. 50% of patients die within a year and 90% die within three years. A combination of treatments are used to treat patients but are limited in their efficacy due to the physical location of the tumour and the aggressiveness of the condition. Double Bond has developed SI053, a unique polymer matrix that contains temozolomide to locally treat brain tumours without harming healthy tissue. Temozolomide is a first line, highly potent chemotherapeutic. When administered systemically, it is highly toxic to healthy tissue and its final concentration is significantlly reduced since it has to cross the blood brain barrier. Also, it cannot be administered right after surgery, delaying chemotherapy by a few weeks. Double Bond’s drug delivery platform allows a high concentration of temozolomide to be released slowly and directly to the tumour right after surgery. Research to date on SI053’s use as a treatment for glioblastoma has been highly promising. Double Bond now aims to clinically validate SI053 in a clinical trial, demonstrating proof of concept. The current proposed Phase 1 project will facilitate in the development process and help define clinical and business strategies. SME Instrument funding will allow SI053 to take a substantial step along the path of commercialisation.