RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nano-structured copper coatings, based on Vitolane technology, for antimicrobial applications' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Antibacterial coatings represent a huge market in healthcare and food sectors.CuVito brings together Mexican mining products and European product development, to produce a state-of-the-art copper nano-structured coating. Bacteria in hospitals present a major health issue.The effectiveness of cleaning is considerably enhanced on smooth, scratch-free surfaces.Anti-bacterial silver coatings are available; however they are not used in hospitals due to cost, effectiveness and durability.Copper offers a low cost, effective and environmentally friendly solution that could be readily adopted. The challenge is to retain copper nano-particles in a structure that provides antibacterial functionality, but prevents leaching.The CuVito consortium believes that the silsesquioxane structure, formed using Vitolane technology is the answer.Silsesquioxanes have the formula RSiO1.5 (where R is an organic ligand), and form cage or ladder structures.They confer hardness and abrasion resistance to coatings and, by selecting appropriate R groups (e.g. acrylate, glycidoxy) can chemically bond to the organic resin in the formulation controlling cross-link density to enhance durability.Hence silsesquioxanes are inherently suited to use in coatings for surfaces which require regular cleaning.Silsesquioxanes have been available for some years but at a prohibitively high cost, due to the complexity of manufacture.Vitolane technology is an alternative, cost effective production route which has been patented and is currently being scaled up commercially.It has a unique processing feature in allowing simple selection of R groups and it is proposed to use this to bond directly to the copper nanoparticles, resolving the issue of leaching.The objectives of the project of the project are:1.Develop a copper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Queer-Arab-French: Sexuality, Islam and Citizenship in France' (QAF).

assistant: **Innovation**

How do North African (Maghrebi) men and Maghrebi-French men negotiate and understand same-sex desire when living in a French urban context?  Does the ethnic North African, who pursues erotic same-sex relationships in France, identify himself as ‘gay’ or ‘homosexual’? During the Fellowship, my broad goal is to address these questions through the completion of a monograph, titled Queer-Arab-French: Sexuality, Islam, and Citizenship in France.  It consists of an ethnographic study of same-sex sexualities, which is based on interviews with Maghrebi and Maghrebi-French homosexual males in major urban centres in France.  I will work with specialists in French studies, linguistics and Communication Studies at Nottingham Trent University (NTU) to analyze how every-day speech and urban space influence Maghrebi-French understandings of sexuality and citizenship.  My project will demonstrate how Maghrebi and Maghrebi-French men may explain their sexuality in terms of a modern ‘coming out’ narrative, documented in the recent scholarship on French homosexuality.  Nevertheless, North African sexual minorities are able to negotiate cultural hybridity, interculturality, and ‘belonging’ in a ‘third space’ that combines elements from traditional and modern discourses such as family, honour, face-saving, the symbolic order of gender differences, as well as the western constructs of individualism and sexual autonomy.  These men also address broader public policy debates on Islam, Islamaphobia, and homophobia.  My project aims to create a new critical framework for examining Muslim sexual minorities and to inform the work of academics in a variety of disciplines, as well as that of activists, politicians and healthcare workers.  Since the staff and students I would work with at NTU investig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'From Skin to Skeleton: Revolutionary Contactless and Non-Ionizing 3D Digital Diagnosis and Monitoring of Spinal Disorders in Adolescents' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Scoliosis is a 3D musculoskeletal disorder of the spine that affects the quality of life and physical ability of patients. Almost 80% of all cases comprise of adolescent idiopathic scoliosis (AIS) with an estimated prevalence of 36 million new patients worldwide by 2050. The drawback of current diagnostic methods in AIS assessment is their harmful effect, especially due to the multiple radiographic exposures required for monitoring disease progression. A new generation of optical techniques for estimating curvature of the spine and evaluating deformity-related changes from a 3D digitalized surface of the patient’s back are considered as an alternative to ionizing methods. However, none of these non-ionizing approaches have been applied to calculate the internal parameters of AIS and neglect the 3D complexity of the internal spinal structure. The proposed action aims to test and improve a markerless computer-aided optical solution (ScolioSIM1.0) that can generate a 3D model of the patient-specific scoliotic spine, and to reliably predict internal and external biomechanical characteristics and parameters of AIS without exposing patients to ionizing radiation. This process includes the development of a novel computational algorithm for online monitoring of AIS after treatment and regular follow-ups (ScolioSIM2.0) and its integration into the first multi-modular web-based platform (ScolioMedIS). The fellowship involves an experienced candidate, Dr Saša Ćuković, from UniKg, Serbia to conduct this multidisciplinary and innovative project at ETH Zurich in the group of Prof. Dr William R. Taylor. The action also provides opportunities for two-way knowledge transfer in the field of musculoskeletal modelling, computational biomechanics and new ICT methods thus, presenting a clear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Strengthening Manila clam's resilience to climate change-related stress and pathogens' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

SHIELD addresses a critical challenge in aquaculture: improving the resilience of Manila clams (Ruditapes philippinarum) to environmental stressors like Perkinsus infections and heatwaves. These stressors have caused widespread mortality in clam populations, threatening the sustainability of this important industry. Through a combination of laboratory and field experiments, SHIELD seeks to investigate two key hypotheses that aim to tackle these challenges from a new perspective.The first hypothesis focuses on the transgenerational effects of Perkinsus infections, examining how parental exposure to the pathogen may affect their offspring's health, growth, and survival. This area remains largely unexplored, and SHIELD aims to shed light on how the effects of infections can be passed down through offspring. By using advanced genomic and epigenomic tools, SHIELD will examine how these changes are inherited and influence the overall fitness of future clam populations.The second hypothesis examines how early microbial exposure can influence the clam’s ability to cope with environmental challenges. Hatcheries typically raise clams in sterile conditions, which might leave them more vulnerable to stressors later in life. SHIELD will test whether exposing clams to a microbiota-enriched environment early in their development can lead to better growth, disease resistance, and survival outcomes when facing real-world stressors like heatwaves and pathogens.By integrating advanced genomic techniques and insights from fieldwork, SHIELD will provide a deeper understanding of how microbiota, pathogens, and environmental stressors interact. This research could offer valuable insights that support more sustainable aquaculture practices, helping ensure the resilience of Manila clam farming
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Reversible Encapsulation', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Drug delivery is the major hurdle to success of therapeutic treatments. A large number of potential drugs with high intrinsic activities fall by the wayside during the development because they have unfavourable physicochemical properties.The aim of this proposal is to develop a general strategy for the encapsulation of guest molecules inside container molecules. Current encapsulation strategies make use of- strong covalent bonds to form the molecular container under kinetic control, which results in essentially irreversible imprisonment of the guest; or- weak non-covalent interactions to assemble the capsules under thermodynamic control, leading to relatively labile products.Neither of these strategies is suitable for drug delivery. We will develop a new strategy towards encapsulation using thermodynamically controlled synthesis to assemble capsules that are held together by covalent bonds that are stable under ordinary conditions but that will release their guest under the influence of a physiologically relevant trigger.Capsules will be assembled by linking relatively simple building blocks together through disulfide bonds. We will prepare equilibrium mixtures (dynamic combinatorial libraries) of potential capsules under conditions of reversible disulfide bond formation. Introduction of a guest molecule into these mixtures should lead to the stabilisation of those capsules that can accommodate this guest.The concentration of the best capsules will increase, which should enable their identification. Once the structure of the selected capsules has been elucidated the same reversible chemistry can be used for thermodynamically-controlled capsule synthesis.Then, the conditions required for the release of the guest from the resulting capsules will be established in model sy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of the Aph-1 proteins in the regulation of the gamma-secretase' (APH-1-RIP) targeting Sixth Framework.

assistant: **Abstract**

The intramembrane proteolysis of the Amyloid Precursor Protein (APP) is the final step in the release of the amyloid peptide, the major constituent of the amyloid plaques in Alzheimer's disease. The protease complex responsible for this proteolytic event consists of Presenilin 1 or 2, Nicastrin, Aph1a or Aph1b, and Pen 2.It is presently not known whether different gamma-secretase complexes exist or whether there is tissue and/or substrate specificity of these complexes. It is also unclear whether other proteins are involved in the regulation or activation of the complex. The current proposal aims to address the question on the function of Aph1a and b using cell biological and biochemical approaches in yeast, Mus Musculus and derived cell lines.The results of this research will have implications for the better understanding of the novel cellular mechanism of regulated intramembrane proteolysis, and could also profoundly affect strategies to cure Alzheimer's disease aiming at lowering amyloid peptide production by targeting gamma-secretase processing of APP in a more specific way at the level of gamma-secretase.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Universal Pulses for Parallel Transmission and Magnetic Resonance Imaging' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The parallel transmission technology is a promising technique to counteract the radiofrequency (RF) field inhomogeneity problem in Magnetic Resonance Imaging (MRI) at ultra-high field. It consists of placing around the subject several RF transmitters that can be controlled independently in amplitude and phase. By using sophisticated algorithms, it is then possible to design the respective waveforms which lead to a uniform excitation. This powerful tool on the other hand has remained a research instrument mostly due to the calibration and calculation time necessary to exploit the technology in each exam (around 10 minutes), and the required expertise to calculate the waveforms. In this Proof-of-Concept project, we propose to establish the scientific validity, technical feasibility and market potential of universal RF pulses. The instigator of the project indeed has acquired supporting evidence during his ERC project that it is possible to generate a set of RF pulses predesigned to be robust with respect to patient variability. That way, the so-called “universal pulses” can be applied to a category of patients without any special calibration or particular expertise. The use of parallel transmission thereby could become accessible to any clinical MRI platform equipped appropriately. Universal pulses would represent a “plug and play” solution. This Proof-of-Concept project hence will be carried out by first accumulating the data necessary to create a database of RF field maps acquired on different human brains. Through the use of tools developed during the corresponding ERC project, the pulses will be designed to work robustly on the cohort. These pulses will then be blindly applied to a group of new healthy adult volunteers without any particular calibration or calculation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Low temperature active urea based selective catalytic reduction of nox (LOTUS)' (LOTUS) under Fifth Framework.

assistant: **Objectives**

The NOx reduction technique that seems most promising for diesel engine applications is selective catalytic reduction with urea since it is not sensitive to sulphur in the fuel. In this project the focus is on new catalyst materials which will expand the active temperature window towards lower temperatures and also on developing a heat management system that will keep the catalyst at its most active temperature region. The goal of the project is to show the potential for an urea based SCR system to comply with the Euro-IV and Eur-V legislative objectives year 2005 and 2008 for heavy duty diesel engines at transient urban driving as well as highway driving with an optimal fuel consumption. The project also includes development of NH3 and NOx sensors that will be instrumental for the OBD and feed back on a closed loop emission control system, in order to reduce the amount of reducing agent and consequently the NH3 slip.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Efficacy and safety of low-dose IL-2 (ld-IL-2) as a Treg enhancer for anti-neuroinflammatory therapy in newly diagnosed Amyotrophic Lateral Sclerosis (ALS) patients' under Horizon 2020.

assistant: **Concept**

Amyotrophic Lateral Sclerosis (ALS) is a fatal degenerative disorder of the brain and spinal cord affecting some 40,000 individuals in Europe, causing 11,000 deaths each year. Our pioneering work on riluzole showed that it is possible to modify ALS progression but all subsequent trials of potential neuroprotective agents have failed. Thus, drug development in ALS, including trial design, patient selection, and outcome measures must be re-engineered to break the current impasse. Nerve cell death in ALS is associated with inflammation, which contributes to cell damage, and is a logical target for therapy. Although therapeutic attempts to modify this have failed so far, the discovery of regulatory T cells (Tregs) as key players in controlling inflammatory processes opens new possibilities since defective Treg function is important in ALS. In fact, Treg numbers and function predict rates of disease progression and survival. Low-dose interleukin-2 (ld IL-2) safely and specifically increases and activates Tregs in conditions such as type 1 diabetes, HBc-vasculitis and chronic graft-versus-host disease, so ld IL-2 has the potential to significantly improve survival and deliver a therapeutic breakthrough in ALS. We also integrate biomarkers for nerve cell damage into the trial design to provide proof of concept/mechanism. “Modifying Immune Response and OutComes in ALS” (MIROCALS) will test the hypothesis that ld IL-2-induced increases in Tregs result in decreased rates of nerve cell damage and that this effect can be detected early in the course of the disease using a range of blood and cerebrospinal fluid biomarkers. Our ambition is to develop a new therapy for ALS and through this novel trial design break the impasse in drug development of other disease-modifying agents in AL
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Integrated Solutions for Improve the quality of the rest' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The present project, ALL4REST, is focused on the development of comfort-improved rest systems, using non-obstrusive technologies that promote deeper, more restorative sleep and prevent nocturnal awakenings. The successful solutions will reduce awakenings and/or reduce time to sleep after an awakening and reduce sleep onset latency. Within the global comfort improvement, physical and thermal parameters will be investigated, establishing quantitative and qualitative evaluation of comfort and sleep quality system. To achieve it, use of biomaterials and research of new ones, eco-friendly technologies and processes in fabrics destined to rest will allow the development of new products focused on obtaining an improved rest system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Data assimilation in readiness for ENVISAT' to be submitted under Fourth Framework.

assistant: **Abstract**

This proposal is for a two-year Concerted Action on data assimilation in readiness for the receipt of Envisat data. The Concerted Action involves a partnership between groups engaged on projects, already funded, concerned with the development of data assimilation and related techniques for applications in Earth Observation. The proposed partnership is between the following groups: (1) Centre for Global Atmospheric Modelling, University of Reading, U.K. (co-ordinator), (2) Meteorological Office, U.K., (3) Institut Pierre-Simon-Laplace, France, (4) KNMI, Netherlands, and (5) University of Koeln, Germany. This partnership will have strong links with the European Centre for Medium Range Weather Forecasts. The proposal seeks costs (57 kEcu) for meetings, workshops and travel to promote the collaboration between these partners and other interested parties; it does not seek funding for specific research. The project aims to fill an important strategic gap in the European Envisat mission, for which no formal provision has been made to use the sophisticated methods of data assimilation to exploit costly Envisat data to the full. The objectives are: (1) to co-ordinate the interaction between European groups in order to build a capability in data assimilation to process Envisat data for the atmosphere, and thereby to improve the quality and cost-effectiveness of the data, (2) to facilitate exploitation of the products of data assimilation by a diverse user community, (3) to link instrument developers with groups involved with data assimilation in order to improve the calibration and validation of Envisat data, and (4) to identify gaps in existing capabilities to exploit Envisat data, to produce recommendations for future programmes and to co-ordinate bids for funding at national a