RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Lipid flippases - Protein-mediated lipid translocation Regulation and physiological significance of transbilayer lipid distribution' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The dynamics of biomembrane lipid organisation and its physiological role is a rapidly developing interdisciplinary field. Membrane dynamics is largely controlled by lipid transporters also known as flippases, which play a pivotal role in cell homeostasis. Putative flippases belong to various subfamilies of the P-type ATPases and ATP-binding cassette (ABC) transporters. These proteins are involved in regulating lipid asymmetry, cellular signalling, in the budding of transport vesicles and protein synthesis. Dysfunction of flippases causes severe diseases like cholestasis, atherosclerosis, visual impairment, what emphasises their crucial physiological function. Although these proteins have been connected with the translocation of various classes of membrane lipids across cellular membranes, biochemical and genetic proof of their function and the key features of their activity remain to be elucidated. The network teaming 12 groups is aimed at undertaking an interdisciplinary effort to reveal the molecular identity and cellular localisation of flippases, their three-dimensional structure, substrate specificity, the molecular mechanism, energetics and regulation of their functioning, as well as unraveling the consequences of their action for cell and body physiology. Biophysical approaches will be used to address lipid transport energetics and its role in membrane budding, fission and fusion. The teams have complementary expertise at the highest standard in all required techniques of molecular and cell biology, biochemistry, proteomics, structural biology including X-ray crystal analysis and cryoelectron microscopy, and theoretical and experimental biophysics. In addition to providing novel applicative insights into flippase-related diseases, this project will identify pote
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dissecting the mechanistic basis of moon-controlled monthly timing mechanisms in marine environments' (2014-2020).

assistant: **Innovation**

The correct timing of biological processes is crucial for organisms. The moon is an important timing cue for numerous marine species, ranging from brown and green algae to corals, worms and fishes. It acts either directly or via the synchronization of monthly (circalunar) inner clocks. Such lunar timing mechanisms typically control the gonadal maturation and behavioral changes associated with reproductive rhythms, including spectacular mass-spawning events. Despite their biological importance, the mechanisms underlying circalunar clocks, as well as their responses to naturalistic stimuli are unknown.My lab has spearheaded research into the mechanisms underlying circalunar timing systems, establishing tools and resources for two well-suited, complementary animal models: Platynereis dumerilii and Clunio marinus. We unraveled first principles of the circalunar clock, e.g. its continuous function in the absence of oscillation of the daily (circadian) clock. Recent unpublished work revealed the first gene that functionally impacts on circalunar rhythms.By capitalizing on these powerful tools and key findings, my lab is in a leading position to dissect the mechanisms of circalunar clocks and their interaction with other rhythms and the environment via three objectives:(1) A reverse genetic approach to unravel how nocturnal light sets the phase of the monthly clock.(2)  A forward genetic screen to identify molecules involved in the circalunar clock, an experimental strategy that was the key to unravel the principles of animal circadian clocks.(3)  By growing animals in outside tanks and subjecting them to established analyses, we will test our lab-based results in more naturalistic conditions.This project will substantially deepen our mechanistic insight into marine rhythms –
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding Notch function in cell architecture regulation' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Notch signalling, a cell communication pathway conserved throughout the animal kingdom, is involved in many developmental processes and linked to many diseases including cancers. While Notch signalling is well known for its function in cell fate control, it has also been implicated in regulating cytoskeleton and cell morphology. For example, Notch is required in Drosophila for the formation of an actin-myosin fence between dorsal and ventral compartments in the wing, for the migration of border cells in the ovary and for correct axon connectivity in the nervous system. However, although the regulation of cell architecture and behaviour is a key process during morphogenesis and tissue formation, it is unclear how Notch exerts its effects on these processes. The aim of this proposal is to identify and analyse new Notch target genes involved in cell architecture regulation. Amongst direct Notch targets identified through genome-wide expression array and chromatin immunoprecipitation are a cohort of genes implicated in cytoarchitecture regulation. Using a combination of genetic approaches, I intend to investigate the function of these novel genes in wing disc formation, border cell migration and axon pathfinding to elucidate their contribution to these morphogenetic processes regulated by Notch. In addition, biochemical, molecular and cellular analyses will be used to assess their functions. Through these approaches I aim to determine which genes play a role in directly transducing the consequences of Notch activation into changes in cell behaviours. Discovering genes that mediate effects of Notch on cell architecture should provide new insights not only for the understanding of Notch function in development but also for the understanding of tissue morphogenesis in general.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Noise and industrial chemicals: interaction effects on hearing and balance'.

assistant: **Innovation**

It is estimated that some 30 million people may work in environments where industrial chemicals may pose a serious hazard to hearing and balance. The effect of solvents on hearing has largely gone unnoticed as hearing impairment has been attributed to exposure to noise, which coexists in industry and the possibility of potentiation by solvents remains unchecked. This study willa) Develop an appropriate test battery and unified protocols to examine individual exposure to solvents and noise and their effect on the peripheral and central audio-vestibule systemsb) Determine the dose/response relationships of exposure to toluene, styrene, xylem, trichloroethylene, and carbondisulfide alone and in the presence of noise in workers exposed to these in industries across Europec) Determine the mechanisms of action of the toxicants and the influence of other risk factorsd) Develop Hearing Conservation strategies that incorporate solvent ototoxicity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'AXES - Access to Audiovisual Archives' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The goal of AXES is to develop tools that provide various types of users with new engaging ways to interact with audiovisual libraries, helping them discover, browse, navigate, search and enrich archives. In particular, apart from a search-oriented scheme, we will explore how suggestions for audiovisual content exploration can be generated via a myriad of information trails crossing the archive. This will be approached from three perspectives (or axes): users, content, and technology.<br/>Within AXES innovative indexing techniques are developed in close cooperation with a number of user communities through tailored use cases and validation stages. Rather than just starting new investments in technical solutions, the co-development is proposed of innovative paradigms of use and novel navigation and search facilities. We will target media professionals, educators, students, amateur researchers, and home users.<br/>Based on an existing Open Source service platform for digital libraries, novel navigation and search functionalities will be offered via interfaces tuned to user profiles and workflow. To this end, AXES will develop tools for content analysis deploying weakly supervised classification methods.Information in scripts, audio tracks, wikis or blogs will be used for the cross-modal detection of people, places, events, etc., and for link generation between audiovisual content. Users will be engaged in the annotation process: with the support of selection and feedback tools, they will enable the gradual improvement of tagging performance.<br/>AXES technology will open up audiovisual digital libraries, increasing their cultural value and their exposure to the European public and academia at large.The consortium is a perfect match to the multi-disciplinary nature of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mobile Microwave Pyrolysis Plant turns Biomass into Fuel Locally' in the context of a Seventh Framework call.

assistant: **Objectives**

Around 15 million private forest owners own about 60% of the forest land in the EU. Privately-owned forests have an average size of 13 ha, but the majority of them are less that 3 ha in size. This group supplies the raw material for the forest based industries with the help of 492,000 people employed in forestry. Forestry and forest-based and related industries employ about 3.4 million people. European forest management is threatened by the prospect of increasing labour cost and stable or even falling prices for forest products, partly due to the availability of extremely productive and cheap sources of wood fibre outside Europe. The industry suffers from severe job losses due to continued increases in mechanisation without a corresponding increase in production and only 60% of the annual forest growth is being harvested. At the same time estimates indicate that EU will fall short by about 46 Mtoe of the target for renewable energy in the redefined Biomass Action Plan of 2005. Our response is to increase the value of tree felling by developing a mobile very rapid (< 1s) pyrolysis plant that can process forest floor residue and wood waste on location to bio-oil and charcoal. 15 Mtoe of forest residue of little or no commercial value at present can be turned into fossil fuel replacements Competitiveness will improve or be sustained for all players in the forestry and forest based industry sector and manufacturers of machines and equipment will get huge exportation opportunities. Job creation is estimated to more than 10,000 whereof almost 3,000 will be in rural areas with forest after year 4 with 400 plants in operation and 400 manufactured per year. 400 plants will produce 1.62 Mtoe of bio-oil that will replace fossil heavy fuel oil to reduce fossil CO2 emissions by 5.4
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The Deep Sea & Sub-Seafloor Frontier'.

assistant: **Innovation**

The Deep Sea and Sub-Seafloor Frontier project (DS³F) provides a pathway towards sustainable management of oceanic resources on a European scale. It will develop subseafloor sampling strategies for enhanced understanding of deep-sea and subseafloor processes by connecting marine research in life and geosciences, climate and environmental change, with socio-economic issues and policy building. Subseafloor drilling and sampling provide two key aspects for understanding how deep-sea ecosystems presently function and how they may respond to global change: (a) an inventory of current subsurface processes and biosphere, and their links to surface ecosystems, utilising seafloor observation and baseline studies and (b) a high resolution archive of past variations in environmental conditions and biodiversity. For both aspects, an international effort is needed to maximise progress by sharing knowledge, ideas and technologies, including mission-specific platforms to increase the efficiency, coverage and effectiveness of subseafloor sampling and exploration. The deep biosphere has been discovered only within the past two decades and comprises a major new frontier for biological exploration. We lack fundamental knowledge about biomass distribution, diversity and physiological activity of deep biosphere communities at life’s extremes, and their impact on seafloor and deep sea ecosystems. Similarly, the geodynamic processes fuelling biological activity, and how these processes impinge upon the emission of geofuels, hydrocarbon formation and other resources including seafloor ecosystems, need to be understood. This Coordination & Support Action will develop the most efficient use of subseafloor sampling techniques and existing marine infrastructure to study the geosystem, its effects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'CONVIVIO - The Network for People-Centred Design of Interactive Systems' (CONVIVIO), addressing dissemination and exploitation.

assistant: **Impact**

Convivio: the Network for people-centred interactive design, aims to provide a supportive infrastructure for an emerging interdisciplinary community of researchers and practitioners involved in the design and use of novel information and communications technologies that service human needs. This emerging community is intrinsically international and multi-disciplinary and needs to be sustained to become an important voice in the ICT research arena.Convivio therefore needs to:- maintain an open, global perspective that encompasses those involved in examining technological vistas - forms, patterns, products and services - in the next 10-20 years;- establish a Network of competencies, a multidisciplinary virtual centre of excellence, that can support both short-term and long-term activities;- provide informed independent input on the development of technologies that will impact profoundly on the everyday life of individuals and communities into European decision-making bodies and actors;- be based in Europe with an international constituency;- work by the community and for the community, always seeking novel mechanisms for collaboration which can release the highest levels of dynamism and creativity among the community members.In this way, Convivio will allow the community to overcome these difficulties in its first phase of organised life (2002-2005). After this period, the community should become able to continue independently, requiring support from the European Commission only for sponsorship of its most important initiatives (conferences, summer schools, magazines).Convivio plans to meet its objective delivering to its reference community a variety of services that will(1) promote the external visibility of the work carried on in it and;(2) help it to share experiences
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Rotating Opto-Magnetic Analysis System' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The purpose of this PoC project is to develop a prototype of portable, highly sensitive and low cost technology for point-of care detection of inflammatory diseases biomarkers. At DTU Nanotech we have developed a completely new technology which holds a great potential to become, in a short period, an extremely useful tool for small medical facilities, family doctors, and chronically ill patients. The core readout element is represented, as in the HERMES project, by an optical pickup head, as used in CD, DVD-ROM or BLU-RAY, which embeds in a single optical path both a laser source and a high-resolution photodetector. By measuring how the light is scattered by magnetic nano-particles actuated by an external AC field we have demonstrated that it is possible to detect low concentration of analytes present in the sample. The key feature of our invention is that blood preconcentration and analyte readout are integrated into the same magnetic-based operations, leading to a compact, low-cost and user-friendly device. Doctors will benefit from our technology which allows performing multiple analyses without relying on centralized laboratories. A fast technology capable to detect multiple parameters would for example allow patient screening at the family doctors’ offices, or would allow chronic diseases patients to be monitored without the need of regularly going to the hospital. The scope of the project is both to provide a benchmarked prototype and to identify the best approach to commercialize the invention. The PoC grant will provide the instruments for understanding the low-cost point-of-care market more deeply, in order to start addressing as soon as possible the challenges of breaking through a complex market such as human diagnostics. Thanks to the intrinsic low-cost of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'BIMcert –  1. Construction skills,  2. Energy efficiency,  3. Regulating supply chains,  4. Tackling climate change' under Horizon 2020.

assistant: **Concept**

A Transparent Training Model and toolkit enabling and empowering industry to achieve a greener built environment.To develop a more efficient and relevant training programme materials to integrate concepts of sustainability and renewables together it practical application and integration with technology ( BIM) based on real life industry needs and limitations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A 27 MWE REFUSE DERIVED FUEL (RDF) GASIFICATION PLANT AT ANO LIOSIA' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

To design, construct and operate a 27 MWe net RDF gasification plant for the energetic utilisation of the RDF produced by two MSW recycling plants. The project also aims to demonstrate the technical and economic viability of the TPS circulating fluidized bed gasification technology for large scale projects as a competitive alternative to landfilling and incineration. The gasification plant will be integrated in a Total MSW Management Facility at Ano Liosia and will be an integral part of the energy related installation (other include landfill gas, and biogas from anaerobic digestion). The gasification island will provide more than 53% of the electricity produced from the facility at Ano Liosia. This plant will be the first thermochemical conversion facility for waste ever built in Greece.The vast majority of the MSW stream in Western Attika is landfilled in the Municipality of Ano Liosia, which is located about 14 km Northwest from the centre of Athens. Currently this landfill receives 3600 tonnes of MSW per day. The surface area of the site related to MSW disposal operations is approximately 500000m² constituting one of the largest operational landfills in the EU. The Ano Liosia landfill receives very high priority in terms of ameliorating the environmental pressures.At present the following units are operational and/or planned at the site:- The rehabilitation of the existing landfill (already contracted),- The extension of the rehabilitation of the existing landfill (already contracted),- The planned sanitary landfill (already contracted),- The planned resource separation for the treatment of 1200 t/d; about 1/3 of the total input (already contracted),- The planned aerobic composting unit (already contracted).The RDF is fed into the gasification system through two par