RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Non-Invasive Optical Biopsy for Cancer Assessment using ultra high resolution Full-Field Optical Coherence Tomography' to be submitted under Seventh Framework.

assistant: **Abstract**

Along the cancer care workflow, existing preoperative and intraoperative procedures such as the identification of small tumourous areas or the precise resection of tumors show significant fail rates, due to the inability of current imaging techniques to perform a reliable in situ diagnosis. Moreover the complete pathological diagnosis, often based on histology slides preparation, is usually only available after a few days. For these reasons a significant number of patients need to undergo secondary biopsy or surgery.The CAReIOCA project aims at providing pathologists and/or surgeons novel non-invasive optical imaging at the cellular scale for fast cancer assessment. By providing images approaching the level of information of histology slides during localization, biopsy and resection procedures in real or near-real time, the technique is expected to significantly improve cancer care. The project will combine latest advances in CMOS technology and optical biopsy" techniques to overcome the current technical limitations of an unequalled performance non-invasive tissue imaging technique: Full-Field Optical Coherence Tomography (FFOCT). The key technological achievement of the project will consist of the development of a specific high-performance CMOS smart camera, and will lead to the development, clinical adaptation and pre-clinical validation of a novel optical biopsy probe, exhibiting in-depth imaging capabilities and a record 3D resolution.The technique will provide a fast and reliable method to visualize pathological or suspicious areas, and corresponding microstructures, in real-time. In particular, it will enable pre-operative diagnosis, biopsy guidance, as well as intra-operative, large-scale surgical margin assessment. These applications are expected to significant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A revolutionary blood test to easily diagnose and prevent deadly complications of organs and tissue transplants.'.

assistant: **Concept**

Transplantations are life-saving treatments, often representing the only option for people with severe disease such as bloodcancers. Unfortunately, complications linked to transplants are so high that they are current limiting the increase of adoptionof transplantations. Specifically, Graft versus Host Disease occurs in up to 80% cases after receiving bone marrow from adonour and poses a serious threat to the life of patients already in critical condition. Graft versus Host Disease, today, canonly be suspected when it is already at an advanced state, i.e. when clinical symptoms appear. However, symptoms are notunique, thus invasive biopsies are needed for a certain diagnosis. At this stage, even more time has been wasted beforestarting an effective drug treatment: the mortality risk can reach 95%, the hospitalization period lasts months instead thanweeks and so drug treatments, that have to be stronger and more aggressive. MarxBio for the first time in the world was ableto link a particular enzyme called GSK-3beta to the onset of Graft versus Host Disease and, specifically, to the proliferationof donor’s T-cells that attack the host. The Company has the unique knowhow to monitor the complex pathways ofGSK-3beta to diagnose and monitor the progression of the disease, through the use of tens of different, specific antibodies.All of this know-how has been enclosed in a disposable protein chip, so a simple blood test, instead of a biopsy, is requiredto detect the disease: results can be obtained in every laboratory, with the use of a standard fluorescence scanner. Scientificresults have been published and intellectual property has been protected with a patent portfolio. During Phase 1 project theCompany will assess the scale-up plan and the clinical trials to be conducted t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biomedical Imaging & Informatics – European Research and Training Initiative' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Current research in Biomedical Imaging & Informatics (BI&I) is driven by the interaction of the natural sciences, informatics & engineering, and medicine. Education and training of early stage researchers (ESR) is, however, often still centred within only one of these domains, resulting in researchers often neither acquiring necessary knowledge of clinical needs, nor sufficient understanding of disciplines beyond BI&I.Furthermore, ESR working in BI&I still face a ‘cultural gap’ between natural sciences and informatics & engineering with the natural sciences achieving innovation by basic research and informatics & engineering approaching this through technological applications. However, the traditional separation into disciplines and cultures breaks up once the researcher is faced with biomedical questions. An interdisciplinary education, solid knowledge of areas adjacent to the core research field, as well as  business competences are therefore the keys to successful, innovative research and excellent science.The proposed IDP BERTI aims to meet all these new requirements. BERTI will establish an interdisciplinary and intersectoral European network of computer scientists, natural scientists, engineers, clinicians, and partners from industry, hence meeting the objectives of the EU Innovation Union “to attract and train young people to become researchers and offer internationally competitive research careers to keep them in Europe and attract the best from abroad.” Each ESR will be assigned one academic, one medical supervisor, as well as a mentor from our industry partner GE Global Research, ensuring perfect training for both an academic and industry career.Due to the truly interdisciplinary nature of BERTI, we feel that an evaluation on a solely natural science/engineeri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mobile Worlds: empowering third cultures for sustainable and inclusive mobility' under Horizon Europe.

assistant: **Concept**

The overall goal of MobileWorlds is to explore pathways to better integrate socio-cultural diversity into today's institutions, so they may better deal with contemporary challenges of sustainable mobility and societal inequalities. Such pathways are sought by engaging explicitly with third culture experiences to identify concrete diverse imaginaries and allowing these to feed into equally diverse solutions that can realistically be implemented. Third cultures are unique cultures that emerge from contact with different home and contextual cultures during the formative years of an individual. These third cultures are increasingly common in a globalising world, and may have important repercussions for imaginaries for sustainable and just mobility futures. As such, they provide promising sources for pathways that integrate socio-cultural diversity into today's institutions. Bergen, Norway and Porto, Portugal are known for cultural diversity and advancement in sustainable mobility. Combined, they provide both a Northern and a Southern European perspective and a particularly interesting context within which to research this subject. MobileWorlds delineates four key objectives: (1) To solidify and expand the concept of third cultures, (2) To develop methods and methodologies that encourage artistic engagement of all ages and socio-cultural groups in mobility planning, (3) To engage communities in mobility planning through arts-based events and activities, and (4) To support my future career development through arts-based research and engagement training and expanding academic and artistic networks and experience. The hands-on experience and training will help to accomplish my career goals securing an Assistant Professor position in the field of Mobility Planning or working in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Physics-constrained adaptive learning for multi-physics optimization'.

assistant: **Concept**

About a hundred trillion bytes of data has been created in the world while reading this sentence. Central to big data is machine learning, which is an automated way of transforming information into empirical knowledge. Machine learning techniques have been applied to some fluid mechanics problems with success, but there are still three big open questions: Do machine learning algorithms scale to engineering configurations? (Are they robust?); Can we gain physical insight into the solutions? (Are they interpretable?); Can we extrapolate knowledge to other configurations, such as multi-physics problems? (Are they generalizable?).  Fluid mechanics modelling has been historically enabled by both empirical approaches and physical principles. Machine learning models may not be interpretable and robust, but they excel at empirical modelling. On the other hand, physical principles are governed by equations that do not adaptively change, but they are interpretable and robust. This project will combine physical principles and empirical modelling into a unified approach: physics-constrained adaptive learning for multi-physics optimization of unsteady, unpredictable and uncertain flows. The learned solutions will not violate physical constraints. The technical objectives are to combine physical principles with machine learning; design adaptive multi-physics models by on-the-fly data assimilation; optimize turbulent flows; quantify the uncertainty; and develop a code that wraps around existing simulation software and experiments. This framework will be applied to maximize energy harvesting from aeroelastic systems to produce clean energy; optimize stable aeroengines with low emissions; and reconstruct high-resolution flow fields from low-resolution experimental measurements. We will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fast Data Acquisition and Servo Technologies' to be submitted under Horizon 2020.

assistant: **Abstract**

Fast data acquisition devices and servo technologies are essential in multiple processes that require a fast response to a sensor input. They are present in multiple automatic procedures for the accurate functioning of trains, planes, and robotic systems either for domestic or industrial activities. As a result of the research performed in the SM-DNA-Repair project (ERC-206117), we have developed a fully digital acquisition board superior in most specifications to current technology because it combines, in a single board, high speed, high channels count, easy integration and development, and is cost effective. The new board has already been validated in a relevant Atomic Force Microscopy (AFM) environment (TRL5, Technology Readiness Level 5), being able to reproduce results obtained with analogue devices. Now, I aim to turn the output of the SM-DNA-Repair project into a commercial proposition by exploring the commercial potential of the device and by eventually attract capital for its further development.The ServoTec Proof of Concept project aims are three-fold. First, to perform a market feasibility study of the fast digital servo board developed, in order to exploit the technology integrated into AFM commercial systems for high-speed applications. Second, to make commercially available the technology and to explore other added-value services for wide range applications and customised solutions. Third, to establish the IP position strategy, including the possibility to license the technology to a company that already commercialises data acquisition boards for the general market. These three commercialisation formats will address a global market. Exploratory work regarding competitive analysis, IPR position and strategy and contacts with the industrial sector has been a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Analysis of the action of enod40 on plant differentiation and growth control'.

assistant: **Innovation**

Msenod40 is expressed in differentiating cells from the nodule primordi and in spontaneous nodules of Medicago plants It is proposed that this genes might act as riboregulators", a recently described class of untranslated RNAs involved in differentiation, and we are now analysing their role on nodule morphogenesis and other differentiation processes.  We propose to construct transgenic plants that overexpress the enod40 gene in sense and antisense orientation using constitutive, inducible and/or tissue specific promoters, to analyze its role "in planta". In parallel, using rapid bioassays, structure-function studies will be performed on the Mtenod40 RNA to delimit biologically active regions involved in cell proliferation. This will allow to conclusively answer if any of the small ORFs can indeed be transated or if a novel function the RNA in the cell may be stablished in relation with plant differentiation."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'GENETIC TAILORING OF NOVEL STARCH POLYMERS' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The project aims at producing novel starch polymers in major EU crops such as maize, wheat, potato and barley.Commercial starches generated by mutagenesis and breeding, such as 'waxy' and 'high amylose' have been used for decades in maize. This programme will enable us through an integrated research approach to bypass the biological bottlenecks occasioned by the polyploidy of the wheat and potato genomes. The generation of waxy wheat and high amylose potatoes, previously impractical will be overcomed through a combination of classical breeding and molecular genetics. While the generation of these genotypes would be considered a major accomplishment (for instance waxy wheat is expected to generate novel baking properties and increased bread shelf life), the programme aims in addition to create novel polymers in planta. The purpose is to genetically engineer novel branching patterns into starch in order to alter in an entirely novel fashion important technological attributes such as gelatinization, retrogradation and gel transparency. Moreover, efforts will be directed to master starch phosphorylation in vivo. This will obviate the need for post-harvest chemical processing and will bring wheat and maize to the superior standards set by the biological phosphorylation of potato starch. These polymers in turn will greatly diversify the structure of the substrates available for both classical starch processing and the generation of novel green polymers directly from starch including biodegradable plastics. Efforts will be directed towards increasing the starch dry matter content in order to facilitate processing. Finally, particular emphasis will be placed on understanding the correlation existing between polysaccharide structure and technological behaviour.This can only be a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European research and innovation agenda for future simulation and forecasting technologies' (Pathfinder).

assistant: **Innovation**

The European leadership and excellence in manufacturing are being significantly threatened by the huge economic crisis that hit the Western countries over the last years. More sustainable and efficient production systems able to keep pace with the market evolution are of paramount importance in the recovery plan aimed at innovating the European competitive landscape. An essential ingredient for a winning innovation path is a more aware and widespread use of ICT in manufacturing-related processes. The Pathfinder project investigates, in particular, the role of simulation and forecasting technologies as a lever to increase manufacturing performance and proposes the development of a roadmap capable to clearly point out key challenges for these technologies future development.Pathfinder project's objectives are: to carry out an extensive analysis of the current framework and state-of-the art of the simulation and forecasting technologies taking into consideration main key players, industries and research initiatives; to increase the understanding of how simulation and forecasting technologies can improve manufacturing performance and to develop an impact measuring tool; to analyse current development and needs in order to identify possible gaps and areas that need to be further explored; to identify technological challenges and drivers in line with the needs of the vision for the future of manufacturing; to develop, with the support of experts, a reference document envisioning the advances for simulation and forecasting technologies that could also support the definition of further research streams in this area; to increase knowledge and awareness about the use and impacts of simulation and forecasting technologies by fostering a cross-sector dialogue involving both p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Metastable Excited Electronic States: Calculation and Application to X-ray Absorption Spectroscopy' (MEESXAFS).

assistant: **Concept**

It is proposed that methods be developed that allow one to calculated metastable excited electronic states, which are short-lived states that are metastable with respect to loss of an electron.The goal of this project is to accurately calculate the energy and lifetimes of such states. This will be accomplished by applying a 'transformed complex absorbing potential' to the Hamiltonian. This will result in the separation of the metastable states from the continuum of unbound states. 'Response Theory' will also be employed in order to evaluate multiple potential metastable states all at once.One application of these methods would be to simulate X-ray absorption fine structure (XAFS) spectra. One use of XAFS is in the investigation enzymatic reactions. For example, Prof. Irit Sagi (Weizmann Institute of Science) has developed a time-resolved XAFS method whereby they can observe the first catalytic cycle of an enzyme.This project will involve developing the related theory, implementing the methods into available electronic structure codes, and evaluating the reliability of the results and the influencing factors.This work will be done in the research group of Prof. Peter R. Taylor, University of Warwick. The total cost of this research should be minimal as the computational equipment and software are already available at the university.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Symbiotic interaction with cable bacteria for seagrass health' under Horizon Europe.

assistant: **Concept**

Seagrass meadows are crucial for maintaining healthy coastal environments, yet they are declining globally at an alarming rate. Traditional conservation efforts focus on reducing environmental stressors, but their limited success highlights the need for innovative approaches that do not look at the plants as single entities but acknowledge the role of key symbiotic interactions. One example is the symbiosis between seagrass, lucinid clams and their sulphur-oxidizing bacteria (SOB), which has been shown to enhance seagrass health by mitigating sulphide stress and increasing nutrient availability through nitrogen fixation. However, this symbiosis is absent in seas above 53N, like Wadden and Baltic Seas. Cable bacteria (CB) are centimetre-long, filamentous bacteria, capable of long-distance electron transfer, coupling sulphide oxidation in anoxic sediments with oxygen reduction. These bacteria have recently been found in the seagrass rhizosphere, suggesting they could serve as an alternative symbiotic system, protecting seagrasses in northern regions. Despite reports linking CB presence with reduced sulphide levels, little is known about the mechanisms and potential benefits of this interaction for the plant. The Symbio-CB-Seagrass project aims to investigate the CB-seagrass interaction across spatial and temporal micro- and macro-scales. Through a series of laboratory experiments, I will test whether CB positively impact seagrass fitness by reducing sulphide stress and by enhancing nutrient availability through nitrogen fixation. Field surveys and publicly available data will be used to assess the geographical distribution of these symbiotic systems and whether CB can serve as beneficial symbionts for seagrasses in northern European waters, analogous to the lucinid clams