RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular 2D/Polymer-based Memristors' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Our previous ERC project showed that 2D materials, when combined with molecular components, can be chemically tuned to unlock entirely new physical properties. This molecular/2D synergy enabled unprecedented control over electronic states and interactions, opening the door to transformative device concepts. Building on these breakthroughs, we now propose a new generation of hybrid memristors. By embedding ionic species within molecular polymers containing 2D materials such as MoS2, WS2, and MoSSe, we achieve volatile,analog memristive behavior with ultra-low energy consumption and full CMOS compatibility. These devices operate adaptively, mimicking short-term synaptic responses—something oxide-based memristors cannot deliver—and provide the foundation for real-time tasks such as vision, speech recognition, and neuromorphic signal processing. Volatile memristors offer a direct solution to the von Neumann bottleneck by merging memory and computation at the sensor edge. Instead of wasting energy shuttling data back and forth, information is processed where it is generated. This drastically reduces latency and power consumption while enabling compact, scalable architectures capableof pre-processing massive data streams for AI tasks in real time.This Proof of Concept will advance our patented demonstrator from TRL3 to TRL5. We will fabricate nanoscale, CMOS-compatible devices, integrate them into programmable preprocessing modules, and validate them with industrial partners. The project carries significant risk, requiring new fabrication strategies, system-level integration, and novel architectures. However, the potential reward is substantial: successful outcomes would open the way to using 2D hybrid memristors in applications beyond the reach of conventionalinorganic compo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Translating Epigenetic Memory into Personalized Prognostic Solutions for Chronic Lymphocytic Leukemia'.

assistant: **Innovation**

Predicting the future clinical behaviour of a patient’s cancer remains a major scientific and clinical challenge. Chronic Lymphocytic Leukaemia (CLL), the most common leukaemia in the Western world, exhibits a broad range of clinical behaviours. The disease begins with a premalignant state that can later progress into an asymptomatic, progressive and highly aggressive form with a poor prognosis. Predicting the risk and timing of progression is a major unmet clinical need in CLL. Through our ERC-SyG grant BCLLatlas and previous studies, we have revealed that DNA methylation plays a key role in cellular identity and memory. These observations indicate that: 1) neoplastic cells carry epigenetic imprints of their cellular origin allowing the distinction of epigenetic subtypes; 2) a mitotic clock traces the proliferative history of cancer cells; and 3) stochastically fluctuating DNA methylation serves as a molecular barcode to track cancer evolutionary dynamics. In CLL, all three nuances of epigenetic memory have a profound and independent prognostic impact. Can these independent prognostic variables be integrated into a single score? In TEMPLe, we propose to leverage the rich information on cellular memory that is encoded within the cancer epigenome by integrating these three variables and generating personalized risk-scores to predict future clinical outcomes of CLL. We will make significant steps towards developing solutions suitable for clinical translation by 1) generating a user-friendly digital platform for risk prediction and prognosis assessment, 2) defining the intellectual property (IP) strategy and best exploitation route in close collaboration with the Technology Transfer Office and IP experts. In the medium term this will improve the clinical management of CLL,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ASSET: Analysing and Striking the Sensitivities of Embryonal Tumours' (ASSET) under Seventh Framework.

assistant: **Objectives**

Cancer is hallmarked by multiple genetic aberrations that lead to a functional derangement of cellular signalling networks. Embryonal tumours (ETs) comprising neuroblastoma, medulloblastoma and Ewing sarcoma, occur early in life, and thus may reveal pathogenetically relevant lesions clearer than adulthood tumours which carry passenger mutations accumulated during life. ASSET will exploit this fact by focussing on unravelling the signalling networks and their alterations in ETs. The basic hypothesis is that ETs share common pathogenetic principles that can be captured and made accessible to rational analysis by combining high-throughput and high content analysis of the genome, transcriptome and proteome with mathematical modelling. ASSET builds on a previous FP6 consortium, the European Embryonal Tumour Pipeline (EEPT), which generated high-throughput genomic and transcriptomic data on ETs. ASSET is the next logical step to add crucial functional information that will allow us to generate (i) defined in vitro and in vivo tumour systems; (ii) combined analysis of genomic mutations, transcriptome, miRNA expression and dynamic proteome changes; (iii) systematic perturbations; (iv) mathematical modelling to elucidate pathogenetic networks and their emergent behaviour; (v) the virtuous cycle of model validation in relevant biological model systems and clinical samples towards a major goal. This goal is to identify mechanistically understood network vulnerabilities that can be exploited for new approaches to the diagnosis and treatment of major paediatric tumours.  Elucidating such core mechanisms will (i) improve understanding of and therapeutic options for these devastating childhood malignancies and (ii) enable a rational approach to deal with the complexity of the pathogen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Personalized Prediction and Intervention for Behavioral Avoidance and Maladaptive Affective States', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Accurate forward prediction of maladaptive behaviors and emotional states involved in various forms of psychopathology offers an intriguing avenue for prevention and intervention science. To date, however, such prediction has been limited by a heterogeneity in factors determining individuals' behaviors and emotions. To address this limitation, the proposed project adopts an idiographic (i.e., person specific) approach while focusing on two exemplar targets that constitute transdiagnostic components in various psychological disorders – namely, behavioral avoidance and maladaptive emotional states. Specifically, the project aims to (a) develop person-specific models for predicting the two targets; and (b) use the models to construct a person-specific just-in-time adaptive intervention (JITAI) system, a novel, accessible, and highly promising means for affecting change. To do so, the project will utilize ecological momentary assessment (EMA) and harness three methodological innovations: (1) an adaptive assessment and personalized item-selection tool which will reduce participant burden; (2) a scalable personalized system that provides accurate forward prediction using brief psychosocial questions and automatically-collected timing/location data; (3) a personalized JITAI app that will inform participants in real time regarding increased likelihood of impending targets, and prompt appropriate interventions based on individual predictors. The project can significantly promote understanding of transdiagnostic maladaptive processes and lead to efficient precision interventions. It builds on the fellow's expertise in EMA and affect research and will develop his statistical and analytic tools for exploring ideographic time-series data, his skills in translating such data into tai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Access to the wittgenstein archives at the university of bergen (WAB)'.

assistant: **Objectives**

Description:The Wittgenstein Archives at the University of Bergen (WAB) provides full electronic access to the works of Ludwig Wittgenstein and is central for research in philosophy and science. WAB holds copies of all of Wittgenstein's posthumously published works and the Nachlass, with an ensemble of powerful and especially designed tools for access. As a pioneering text encoding project WAB has also become an international centre for researchers interested in text encoding, document preservation methods and information technology. WAB offers its visitors access to a network of contemporary philosophers, text encoding and information technology specialists, which has been built up over the years of producing a machine-readable version of Wittgenstein's Nachlass.Application:Access to WAB as European Research Infrastructure (ARI WAB) is regulated under contract HPRI-CT-2001-00161 and underlies application and selection procedures. The application form for proposals under this contract, together with application guidelines and information on eligibility criteria and procedures, can be downloaded to your computer from http://www.hit.uib.no/wab/eu-ari/. Proposals will be selected on the basis of scientific merit through an independent peer review procedure and further approval by the Commission. Priority will be given to researchers who are working in regions of the Community where few such research infrastructures exist.Project Manager:Alois Pichler, Wittgenstein Archives at the University of Bergen, Allegaten 27, N-5007 Bergen, NorwayTel: +47-55589474Fax: +47-55589470E-mail: alois.pichler@hit.uib.no
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Feasibility of an INnovative, Efficient, Solid State Energy saving system' under Horizon 2020.

assistant: **Concept**

The overall project objective is to successfully develop and to scale up for market readiness, a sophisticated voltage optimisation system that can reduce electrical energy consumption by up to 20%. The EU consume 3,361.69 TWh of electricity p.a and that is growing, as is our reliance on imported energy.  EU supply standard EN 50160 has been harmonised at a single phase line voltage of 230Vac ±10%,  Consequently actual voltages differ significantly across Europe with from 220Vac, through 230 to 240Vac, with peak mean voltages up to 253Vac. Whilst initially perceived as a UK issue, there are in fact 11 EEA countries which have an upper limit of 230V +10%, and another 13 to follow.  The Business Opportunity is that virtually all European electrical equipment is designed to operate most efficiently at 220Vac. This ‘over voltage’ leads to inefficiency and  losses, (heat, eddy currents, magnetic hysteresis), increased energy bills, increased maintenance, down-time and reduced equipment life. These problems can be solved by reducing and stabilising the line voltage at the point of use, results in energy savings up to 20% if the input line voltage is 253V (230V+10%), thus representing a significant opportunity to reduce electricity bills.  As we will demonstrate in section 1.4, conventional solutions and the current state of the art, do not fully solve this problem and have a number of limitations. There is therefore an urgent, unmet need for a system to reliably optimise electrical energy savings and provide a rapid return on investment for the customer. Our breakthrough solution is novel, patent protected and tested at lab scale. We initially require help to undertake a feasibility study to elaborate and de-risk our business plan. If successful we will unlock a market opport
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Shaping the bacterial envelope: Interplay between the components and impact on antibiotic resistance' in the context of a Horizon Europe call.

assistant: **Objectives**

Gram-negative bacteria are notoriously resilient, dominating the list of pathogens requiring urgent medical attention. Fundamental to their remarkable antibiotic resistance is a tripartite envelope comprised of an inner-membrane (IM), peptidoglycan cell wall (PG) and an outer membrane (OM). While these layers were previously viewed as separate compartments, it is becoming apparent that they work together in order to maintain envelope integrity. However, little is known about the crosstalk between components and molecular mechanisms orchestrating envelope assembly and functionality. Our latest work has identified a key interaction between the PG and the BAM complex which inserts new OM proteins (OMPs), revealing a mechanism coordinating PG and OMP biogenesis and directing them both to the cell center. We posit that coordination is a key principle of envelope assembly and multiple interactions among envelope constituents are waiting to be discovered. In Shape-En-Resist we will uncover novel physical and genetic interactions, identify coordination mechanisms and elucidate their impact on bacterial physiology and antibiotic resistance. To this end, we will focus on three aims: (i) Explore the assembly of lipopolysaccharide (LPS), an endotoxin covering the bacterial surface, and characterize its interplay with envelope biogenesis. (ii) Comprehensively map PG-OMPs interactions and study how they affect bacterial response to antibiotics. (iii) Uncover the outcomes of spatially heterogenous envelope biogenesis and whether this process is a source of phenotypic diversity. To address these questions, a multidisciplinary approach will be taken, combining cutting-edge microscopy, advanced genetic screens, proteomics and novel functionality assays. We expect this project to uncover
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Behavior and fate of dissolved, colloidal and particulate matter in the alboran sea. Physical and chemical characterization' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content This project will examine the three states of the matter (dissolved, colloidal and particulate) collected simultaneously from the different water masses (Atlantic fresher water at surface and saltier Mediterranean waters at depth) of the Alboran Sea. The specific objectives are: - to characterize dissolved, colloidal and particulate matter in term of size distribution, mineralogy, morphology, chemical composition; - to evaluate the role of colloids and particles in the fixation of organic and inorganic pollutants as a function of their nature; - to evaluate the effect of physical and chemical parameters of the water on the morphology and the chemical nature of particles or colloids. Training content (objective, benefit and expected impact) The mixing of water masses in the Alboran Sea is a very complex problem. The knowledge of dissolved, colloidal and particulate matter in the different water masses is necessary to deduce the matter's origine and its mains transport pathways, to better understand the circulation of water masses and to provide evidence about the possible exchanges between the water masses. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Novel diffuse Optical method to combat skin color bias in non-invasive optical biomarker sensing devices such as pulse oximeters' to be submitted under Horizon Europe.

assistant: **Abstract**

During COVID-19, skin color bias in Optical Biomarkers Sensing (OBS) devices (e.g., pulse oximeter) was suspected to have contributed to the loss of lives in darkly pigmented people. The Continuous Wave (CW) technology used in these devices is  limited in accuracy and results are biased by skin color and light scattering in tissue.NOBIAS aims to break through frontiers to create foundational multilayer fast Time Domain Diffuse Optical Spectroscopy (TDDOS) to eliminate color bias and inaccuracy shortcomings of current CW technology and revolutionize the future of bias-free, accurate optical biomarker sensing. To achieve this ambition, NOBIAS will create a multilayer TDDOS dynamic skin tissue model based on Monte Carlo to investigate the effect of skin type and anatomy on color bias, to optimize the concept, device and probe design to compensate and eliminate color bias and inaccuracies (WP1, Obj.1). 2 groundbreaking approaches (i) intermediate hybrid CW-TDDOS fusion approach (phase 1) is envisioned to compensate for skin color bias, followed by (ii) an ambitious new frontier fast TDDOS approach (phase 2) to eliminate color bias (WP2, Obj.2) and provide faster (100-250X), real time measurements at wearable footprint (100X). A first-of-a-kind compensation algorithm based on real-time instrument response function (IRF), and phantom arm aims to deliver groundbreaking accuracy (14X) (WP3, Obj.3). Early benchtop testing and feedback across work packages will mitigate risks of ambitious objectives. NOBIAS paradigm device/algorithm will be validated on tissue-mimicking phantoms and bias-free sensing will be demonstrated on blood biomarkers (haemoglobin (Hb, HbO), oxygen saturation (StO2, SpO2)) sensing at wrist location on healthy i) adults ii) infants (WP4, Obj.4). NOBIAS break
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Engineering the immune response in Parkinson’s disease  to curb its pathological progression' under Horizon Europe.

assistant: **Concept**

Mounting evidence has defined the key role played by the immune system in exacerbating dopaminergic neuron loss in Parkinson’s disease (PD). Pathological alpha-Synuclein (αSYN) activates microglia and recruits inflamed T cells, creating a toxic environment that directly negatively impact on neurodegenerative processes. Blocking or attenuating neuroinflammation can have a strong therapeutic potential in PD, but systemic treatments are associated with immune system general suppression leading to severe and unacceptable side effects. Therefore, a therapeutic strategy for long-term and local immune suppression would minimize adverse effects and provide a long-sought disease-modifying treatment for PD. To achieve this goal, we have generated αSYN-specific CAR T regulatory cells (Tregs) that are activated and recruited only in the presence of toxic αSYN aggregates, suppressing immune activation. Herein, we will determine the therapeutic efficacy of mouse and human αSYN-CAR Tregs in conventional and humanized mice with virally-induced synucleinopathy. These experiments will determine the dose and infusion schedule that will achieve maximal neuroprotection and symptomatic rescue with none or minimal side effects. Moreover, innovative all-human neuroimmune organoids will be generated by assembling patient and isogenic iPSC-derived neural, astroglial and microglial cells together with freshly isolated T cells and αSYN-CAR Tregs. This model will recapitulate human-specific neuroinflammatory processes and validate the capacity of αSYN-CAR Tregs to interfere with them. Finally, we conceived αSYN-CAR Tregs as ideal cellular shuttles for the local delivery of therapeutic molecules and this concept will be explore to express αSYN anti-aggregating agents. This treatment is of potential