RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Synergies of Life and Material Sciences to Create a New Future' to be submitted under Seventh Framework.

assistant: **Abstract**

SYLICA – Synergies of Life and Material Sciences to Create a New Future concentrates on unlocking and developing research potential of CEITEC – Central European Institute of Technology located in Brno, Czech Republic. The SYLICA project applicant is Masaryk University, the main beneficiary of CEITEC, and the second largest Czech university. CEITEC concentrates the best teams (51 research groups and 7 scientific programmes) in  life sciences and advanced materials research, including interdisciplinary interactions with a promising scientific potential. It is both interdisciplinary and international scope, which create the major added value of SYLICA, and which also need further endeavour based on an international evaluation. SYLICA creates important synergies with the EU Structural Funds; CEITEC expects a large investment worth € 163 mil. from the ERDF into the state-of-the-art infrastructure with national and international significance. By combining ERDF and FP7, the EU added value is created, and a strict complementary approach is followed. SYLICA principally concentrates on the missing expertise for the new core facilities of CEITEC. Through a series of workshops, seminars, postdoctoral and expert inter-ships and visits, and reintegration of experienced nationals, the project will strengthen our research potential on one hand in methodologies and techniques needed for the infrastructure, and on the other hand in the interdisciplinary research fields including studies of novel biomaterials and composites with enhanced biological and mechanical properties. SYLICA will foster strategic partnerships with prestigious EU research institutions and attract external users of the infrastructure and research results including industry. It will contribute to the vision of CEITEC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A History of the International Human Rights Regime from the Arab-Islamic World' (UNIVERSALITY).

assistant: **Innovation**

How universal is the Universal Declaration of Human Rights? The question attracts more debate than one might expect. This research project—UNIVERSALITY—will break new ground in such debates by contributing an innovative Global History of the origins and development of the international Human Rights regime after the Second World War, from the perspective of the (Arabic-speaking) Islamic  world. The Applicant is a junior academic—a graduate of the London School of Economics, Yale University and Harvard University—with unique professional experience as a diplomat beyond Europe, research fluency in the Arabic language, and experience in journalism communicating to non-specialist audiences, all of which this project leverages. The fellowship will be carried out at the Freie Universität Berlin (FUB) under the supervision of Professor Sebastian Conrad, one of the foremost practitioners in the project field of Global History. The project deliverables address one of the most pressing historical and social needs for our contemporary multicultural Europe—namely, how we can contribute political histories of the twentieth century that place the agency, experiences and political thought of the non-Western world at the centre of historical action. Through innovative method and using a range of neglected sources, UNIVERSALITY will support this objective through reconstructing a hitherto hidden story of the birth and contestation over the UDHR that can also serve as an alternate origins story for our modern international world. And by foregrounding Arab and Islamic perspectives in debates over the international Human Rights regime, it will offer both academic and public new ways of thinking about how we can include non-Western epistemologies in understanding modern-day processes of glob
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Microwave assisted curing for carbon fiber reinforced epoxy composites', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The main objective of WAVECOM project is the development of a technology suitable for carbon fiber reinforced composites manufacturing based on microwave curing of its raw materials, which includes the selection of the proper additives (dipole organic molecules or nanostructured magnetic materials) and the set up of the system at pilot plant level. A better understanding of potential distortions and residual stress effects of MW will be obtained by using Fibre Bragg Grating technology. Tooling materials and their geometrical limitations will be obtained as well. Finally, an assessment on the final properties of the composites and the benefits of this technology in economic and ecological terms will be also carried out.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Proteolytic processing in plant stress signal transduction and responses to abiotic stress and pathogen attack'.

assistant: **Innovation**

Site-specific proteolytic processing is an irreversible post-translational protein modification that generates distinct protein species with new functions, interactions and subcellular locations. In plants, proteolytic processing regulates hormonal and stress signaling leading to adaptation of metabolic pathways and is implicated in plant-pathogen interactions. Despite their importance, proteolytic processes have largely been identified serendipitously, specific cleavage sites have rarely been identified and only a few of the hundreds of proteases encoded in plant genomes (>800 in Arabidopsis) have been linked to any substrates.Positional proteomics enables system-wide identification of proteolytic processing and protease substrate repertoires through quantitative determination of protein N- or C-termini. ProPlantStress will employ these approaches, which I co-developed during my postdoctoral research, to two linked abiotic and biotic stress conditions: i) Time-resolved mapping of chloroplast protein processing induced by high intensity light will reveal novel mechanisms of retrograde signal transduction, stress response and acclimation; ii) Profiling of protein processing triggered by pathogen recognition, combined with substrate identification for selected host and bacterial pathogen effector proteases will identify proteins with novel functions in plant immune responses and systemic signaling.Importantly, ProPlantStress will not merely catalogue termini and substrates: Mapping of cleavage sites to the protein domains and correlation with other modifications, such as phosphorylation, generates testable hypotheses on the function of processed protein species that will be examined in detail.ProPlantStress will thereby provide fundamental insights into proteolytic mechan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MICROBOTS – Unravel the power of MICRObial metaBOliTeS to prevent graft versus host disease and cure leukemia relapse' (MICROBOTS).

assistant: **Innovation**

Allogeneic stem cell transplantation (allo-SCT) is the most common cellular immunotherapy for hematologic malignancies, but beneficial outcomes are limited by severe morbidity and mortality by graft-vs.-host disease (GVHD) and by relapse as a consequence of insufficient antitumor immune response (graft-vs-leukemia, GVL). In allo-SCT patients, a diverse gut microbiome is associated with beneficial clinical outcomes and fecal microbiota transplantation (FMT) emerges as a promising therapeutic option for acute gastrointestinal GVHD patients. Yet, how the gut and tissue-associated microbiome governs immune function and tissue homeostasis remains poorly understood. We identified microbial signatures - i.e., configurations of microbial communities and their associated immune-modulatory metabolites - in allo-SCT patients that (i) favourably associate with clinical outcomes, (ii) can engage an Interferon (IFN)-I inducing pathway to induce tissue regeneration, and (iii) protect mice from immune-mediated tissue damage. We therefore hypothesize that gut and tissue-associated microbial consortia and their immune-modulatory metabolites serve as a game changer for allo-SCT. “MICROBOTS” will test this by (i) providing a thorough characterization of microbiome/metabolome-host interaction at the epithelial interface in allo-SCT patients with or without GVHD, relapse and undergoing FMT and (ii) evaluating the functional impact of identified microbial signatures in advanced preclinical models of GVL and GVHD. These novel insights will provide a template for the design of a Precision FMT approach with defined microbial-metabolite cocktails aimed to achieve robust and durable antitumor responses in allo-SCT patients as well as to improve tissue regeneration and minimize immune-mediated side
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High Throughput Second Harmonic Method to Probe Biological Surfaces at Real-World Conditions' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Biological surfaces are essential for life. Nature employs them as a hub for chemical signalling, active and passive transport of substances, and specialized compartmentation in the building block of life, eukaryotic cell. As such it has been in the main focus of chemist, physicist, and biologist to probe these surfaces with a wide variety of different techniques; from NMR to STORM. This, in fact, is not an easy task since obtaining selective information only from surfaces generally requires to introduce some reporting molecules (chromophore).  However, the response of a dye molecule is not always, report on the changes on the biological surface. In this IF proposal, the aim is to enable the probing of biological surfaces, free-floating model membranes, label-free, and non-invasive from the response of interfacial water molecules with second harmonic (SH) response. First, a new high-throughput SH setup will be introduced. The proposed ~3 orders of magnitude enhancement in the SH response will enable to probe at biology relevant (~100 mM) salt concentrations. A big accomplishment for the SH research field. Second, by using this new high throughput setup, two different biological membrane systems and reactions occurring there at will be elucidated, biomimetic lipid droplet organelle, and liposomes, two free-floating membrane model system. Due to its novel aspects, a significant impact is expected from the deliverables of this proposal not only for the scientific field, but also possible intersectoral collaboration prospects as well as opening opportunities for the researcher to achieve a permanent position.


**Keywords:** Molecular Structure of Lipids, H2O, Biointerfaces, Surface Chemical Reactions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Synthesis of a new class of potent glycosidase inhibitors: analysis of their biological activities; synthesis of a library of gem-difluoro-carbaglycosides: exploration of sugar-protein interactions' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

This proposal aims to make a major contribution to the European Research Area and add value to the EU in specific ways. The host research group at l'Ecole Normale Superieure has developed a fruitful industrial partnership with Sanofi-Aventis that has led to the release of a new antithrombotic agent Arixtra" on the market last year. This project will synthesise families of related molecules and test their biological activities. The fellowship will allow an exceptional young scientist to diversify his re search, work in a multidisciplinary field gaining new skills in biochemistry and carbohydrate chemistry as well as reinforcing his present skills in synthetic organic chemistry and spectroscopy. These new skills will allow the fellow to reach a position of professional maturity and give him a multidisciplinary platform to begin a career as an EU academic. The project will synthesise several new families of biologically important sugar mimics based on azacycloheptene intermediates and gain access to novel in dolizidine and pyrrolizidine scaffolds through the use of more complex amines. This work will take advantage of the expertise in the Sinay Group and the synthetic skills of the fellow and will be carried out at lÂ¿Ecole Normale Superieure. Biological evaluation of these new sugar mimics will be carried out in collaboration with Prof P. Vogel (Switzerland) and the active conformation of these molecules will be established in collaboration with Prof. J. Jimenez-Barbero (Madrid). A library of biologically important gem-difluoro-carba-sugar analogues will be generated using methodology developed in the Sinay group. These gem-difluoro-carba-sugars will be used to investigate sugar-protein interactions using NMR (19F) spectroscopy in collaboration with Prof. J. J imenez-Barb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Spatially and temporally regulated membrane complexes in cancer cell invasion and cytokinesis' (2007-2013).

assistant: **Innovation**

Cancer progression, characterized by uncontrolled proliferation and motility of cells, is a complex and deadly process. Integrins, a major cell surface adhesion receptor family, are transmembrane proteins known to regulate cell behaviour by transducing extracellular signals to cytoplasmic protein complexes. We and others have shown that recruitment of specific protein complexes by the cytoplasmic domains of integrins is important in tumorigenesis. Here our aim is to study three interrelated processes in cancer progression which involve integrin signalling, but which have not been elucidated earlier at all. 1) Integrins in cell division (cytokinesis). Since coordinated action of the cytoskeleton and membranes is needed both for cell division and motility, shared integrin functions can regulate both events. 2) Dynamic integrin signalosomes at the leading edge of invading cells. Spatially and temporally regulated, integrin-protein complexes at the front of infiltrating cells are likely to dictate the movement of cancer cells in tissues. 3) Transmembrane segments of integrins as scaffolds for integrin signalling. In addition to cytosolic proteins, integrins most likely interact with proteins within the membrane resulting into new signalling modalities. In this proposal we will use innovative, modern and even unconventional techniques (such as RNAi and live-cell arrays detecting integrin traffic, cell motility and multiplication, laser-microdissection, proteomics and bacterial-two-hybrid screens) to unravel these new integrin functions, for which we have preliminary evidence. Each project will give fundamentally novel mechanistic insight into the role of integrins in cancer. Moreover, these interdisciplinary new openings will increase our understanding in cancer progression
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cyber-Physical European Roadmap and Strategy' (CyPhERS), addressing dissemination and exploitation.

assistant: **Impact**

The ongoing integration of software-intensive embedded systems and global communication networks into Cyber-Physical Systems (CPS) is considered to be the next revolution in ICT with a lot of game-changing business potential and novel business models for integrated services and products. CPS will be a core enabling technology for securing economic leadership in embedded systems/ICT, having an enormous social and economic importance, and making decisive contributions to societal challenges.<br/>Europe is well positioned to meet this merging of the physical and virtual worlds.  However, to effectively address the associated challenges, a strategic agenda is needed to ensure Europe's competitiveness. This Support Action will systematically survey, analyse, and evaluate the economic, technical, scientific, and societal significance of Cyber-Physical Systems for Europe. The project will develop an integrated strategic CPS research agenda for Europe, and derive comprehensive recommendations for action that will cover the identification and prioritization of research areas, support measures for both horizontal and vertical cooperation, and an outline of possible research partnerships, and will address questions of research funding as well as the issues of training, standardization and  policies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Super-IcePhobic Surfaces to Prevent Ice Formation on Aircraft' (PHOBIC2ICE), addressing dissemination and exploitation.

assistant: **Impact**

The accretion of ice represents a severe problem for aircraft, as the presence of even a scarcely visible layer can severely limit the function of wings, propellers, windshields, antennas, vents, intakes and cowlings. The PHOBIC2ICE Project aims at developing technologies and predictive simulation tools for avoiding or mitigating this phenomenon. The PHOBIC2ICE project, by applying an innovative approach to simulation and modelling, will enable the design and fabrication of icephobic surfaces with improved functionalities. Several types of polymeric, metallic and hybrid coatings using different deposition methods will be developed. Laser treated and anodized surfaces will be prepared. Consequently, the Project focuses on collecting fundamental knowledge of phenomena associated with icephobicity issues. This knowledge will give better understanding of the ice accretion process on different coatings and modified surfaces. Certified research infrastructure (ice wind tunnel) and flight tests planned will aid in developing comprehensive solutions to address ice formation issue and will raise the Project’s innovation level.The proposed solution will be environment-friendly, will contribute to the reduction of energy consumption, and will help eliminate the need for frequent on-ground de-icing procedures. This in turn will contribute to the reduction of cost, pollution and flight delay.


**Keywords:** Icephobicity,  Icephobic surfaces and coatings,  Superhydrophobic coatings,  Density Functional Theory (DFT),  Volume of Fluid (VOF) method,  Morphogenetic Approach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Low-Cost, Circular, plug & play, off grid Energy for Remote Locations including Hydrogen (LOCEL-H2)' (LOCEL-H2) under Horizon Europe.

assistant: **Objectives**

Many communities in developing regions suffer disproportionately from energy poverty and the effects of climate change. Females in these communities face additional threats, including exposure to harmful cooking emissions. LoCEL-H2 will address underlying causes of these issues by providing renewable, cost-effective, plug-n-play, and sustainable provision of electrical energy and access to clean fuels.Our integrated prosumer renewable energy solution will be developed in harmony with local communities needs; our SSH team will evaluate critical socioeconomic factors for use in system development and future rollout. It is our ambition to provide operational training for deployment communities and future local partners.LoCEL-H2 features three impressive technical innovations: 1) a unique, low-cost, hydrogen-based energy solution, the Battolyser, 2) a novel battery technology, with high performance and excellent circularity, 3) a decentralized, peer-to-peer, prosumer microgrid designed holistically to facilitate sustainable rollout. Following system-level integration & validation (via a virtual pilot and a pre-pilot in Asia at TRL-7), the LoCEL-H2 team will deploy two full-scale TRL-8 pilots in Africa (Cte d'Ivoire and Zambia), including physical, digital, and social tools, achieving TRL-8 by the end of the current project. Our teams existing commercial networksAsian and Africanwill enable the further post-project commercial rollout of LoCEL-H2, boosting European export potential in sustainable energy solutions.


**Keywords:** Prosumer, Social innovation, Gender, Clean Hydrogen Electrolyser, Solar, Battery, Microgrid, Off-grid electrification, Decentralised power systems, Sustainable business models, Environmental impact