RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Knowledge Based Virtual Facilitator in Team Working' (ANGELO) under Fifth Framework.

assistant: **Objectives**

Call-centres are a fast growing source of employment in the European economy: The Project's goal is to use new technology to improve quality of work for operators in the next generation of call-centres. This includes analysis of and design of an advanced system for call-centre operator support, including a broadband IP-network, software-based session interpreter, knowledge base, workflow engine, systems to monitor key environmental and physiological parameters, software based measurement system" to model and anticipate operator needs and requests and an advanced "augmented reality" human-machine interface. The prototype system will be tested by roughly 20 users and will be subject to formal evaluation in terms of its contribution to the quality of working life and its role in fostering equal opportunities, employment and economic growth. Work will be based on an analysis of the needs of call-centre operators and customers and a special user group will provide designers and implementers with valuable feedback. On this basis, the Project will design, build and test an operator support system integrating a number of hardware and software components. The system will be implemented first as a single-user prototype and then in a multi-user version. The multi-user prototype will be tested over a period of 7 months. The test will involve roughly 20 users sharing 2-3 workstations. At the end of the test the system will be subject to rigorous evaluation in terms of its contribution to the quality of working life and potential take up in E.U. countries including indirect contributions to employment and economic growth.Work description:Call-centers are a fast growing source of employment in the European economy: The Project's goal is to use new technology to improve quality of work
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Heavy Ion FLASH', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Charged particle therapy is generally acknowledged as the most advanced type of radiotherapy (RT). Particle therapy patients are treated either with high-energy protons or 12C-ions, but there is a general agreement that heavier ions would be highly beneficial in treating extremely resistant, hypoxic and lethal tumors, such as glioblastoma (GBM). Unfortunately, the use of very heavy ions is constrained by their excessive normal tissue toxicity.A way to enable very heavy ion therapy with acceptable toxicities is to make use of the recently discovered FLASH effect. This effect occurs when ultra-high dose-rate (UHDR) electrons or protons are used and results in significantly sparing the normal tissues whilst maintaining tumour control. Although the molecular mechanism is still unclear, the FLASH effect considerably broadens the therapeutic window and has proven to be a game-changer in radiotherapy. While my group at GSI has pioneered the first demonstration of the FLASH effect with high-energy carbon ions, UHDR use of even heavier ions can be safe and very effective for very resistant tumor. GSI is the only facility world-wide where the FLASH effect can be explored with ions heavier than carbon. In fact, the GSI synchrotron can accelerate all ions for H to U up to very high energy and intensity, and my group has developed a unique technology to perform 3D conformal UHDR irradiation using 3D-printed range modulators. We will perform UHDR irradiation experiments with 20Ne-ions using a GBM rat model and will compare survival, toxicity and tumour control with the same ion at conventional dose-rate and with UHDR protons as a reference. If successful, HI-FLASH will pave the way for the use of heavy ions in cancer treatment, improving outcomes for patients with highly resistant an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Direct Alkylation of Saturated Cyclic Amines via catalytic C-H Functionalization' (DASCA).

assistant: **Concept**

Direct conversion of C-H into C-C bonds is arguably indispensable in modern organic chemistry, as it allows for obtaining target compounds which are otherwise only accessible via lengthy procedures involving multi-step synthesis. Catalytic C-H functionalization is the most attractive approach to achieve this goal, as it does not require stoichiometric amounts of activating reagent. This research proposal aims to develop direct transition metal-catalyzed functionalizations of C(sp3)–H bonds in saturated nitrogen-based heterocycles, with a particular focus on compatibility with a very broad range of functional groups, regioselectivity and stereoselectivity. Towards this goal, insertion reactions with substituted alkenes featuring a variety of functional groups will be explored. The development of such a technology offers an important contribution to novel, improved and more sustainable synthetic pathways and is expected to be highly warranted for drug discovery purposes.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The molecular basis of conductive and vascular tissue development in plants' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Plants contribute up to 80% of all biomass on earth. Despite their staggering diversity; dominant land plants share a highly important characteristic: the presence of a vascular system providing physical support and long distance transport. This is however not a simple binary trait, as some non-vascular mosses contain cells with conductive capacity resembling that of vascular plants. Available evidence indeed suggests that conductive tissues of non-vascular plants are functionally homologous to vascular tissues in vascular plants and can even be compared at a molecular level. However, the molecular players involved in conductive tissue development remain almost completely unknown. Moreover, although key molecular regulators of vascular tissue development have been identified in the model plant Arabidopsis, very few are shown to be functionally conserved across vascular plants. Despite their importance for growth and development, we thus have a limited understanding of the evolutionary conserved regulators of plant plumbing systems.In PIPELINES, I will consolidate my expertise in single-cell applications and build a dedicated team to identify conserved molecular players specific to vascular and conductive tissues by combining multi-species comparative single-cell and spatial transcriptomics with gene regulatory network inference; and characterize these factors using loss-of-function approaches. By comparing this data, I will determine the ancestral set of regulators sufficient to trigger specification and differentiation events in plants; and validate these through introduction of single-cell sample multiplexing in a heterologous system.By unravelling the molecular basis of vascular and conductive tissue development and identifying conserved core developmental regulators
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Elevating Higher Education public policies: an empowering SPRIngboard'.

assistant: **Innovation**

The current world of higher education (HE) has been shaped by two forces: the humanistic traditions of university governance and the neo-liberal reforms of the past thirty years. With its successes and discontents, this hybrid system faces major crises that affect its ability to respond to the needs of society: the tension between traditional and neo-liberal academic values; the biased evaluation and assessment of quality in higher education; the ineffectiveness determined by the distorted measurements of scientific achievements and other factors; the recent digital transformations of the universities facing the pandemic. To face these challenges, HESPRI addresses innovative strategies to strengthen public policies and improve the competitiveness of the HE sector. Specific objectives and originalities, and a well-designed R&I work plan (4 scientific WPs and 2 support WPs) are proposed for achieving this main goal: comparing a range of national HE systems worldwide as a function of cultural practices, for revealing tensions between various categories of values, shaped by global tendencies; exploring, defining and comparing quality in HE in different contexts, in order to provide innovative and advanced methodology; bringing the collective voice of science into the policymaking process in HE, by looking at how disciplinary and national differences affect governance; analysing technology-enhanced higher education environments, beyond the state of the art, around three pillars - digitalisation, metaverse and open science, on specific emerging research topics. Relying on a world-class and culturally diverse consortium, HESPRI aims to provide evidence-based recommendations for governments, policymakers and universities, to adjust various components in trend with recent provoc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Preparing for the construction of the European Extremely Large Telescope' in the context of a Seventh Framework call.

assistant: **Objectives**

In the last 5 years the Science Case for a European Extremely Large Telescope, has been established by the European astronomical community. In 2010 the E-ELT Project shall be ready for decision to build, with in particular a detailed scientific Design Reference Mission, a secured site, reliable expected performance, cost and timeline, analysis of the project risks and associated mitigation plans and a confirmed funding scheme. There are a number of transnational activities which are suited for this Preparatory phase. Besides “E-ELT Prep Management”, there are: International Cooperation aim is to find external partners for the E-ELT development. Industrial Links will strengthen the links with the industrial partners and establish policies on connected issues, e.g. development standards, public relation and knowledge transfer. Design Reference Mission objective is to develop a comprehensive set of observing proposals, in particular to maintain the alignment of the E-ELT Project with its community scientific aspirations and explore its synergies with other large astronomical facilities. Science Access Strategy will define the strategy and requirements for the Telescope Operation and for data access by its Users in order to maximize the Facility scientific impact. Networks of Nodes of Expertise activity will help the European Institutes with prime expertise in the technologies crucial to the upgrade path to coordinate their work and co-opt newly formed groups inside and outside ESO member states. Financial Mechanisms objective is to explore external public and private funding possibilities. Project Structure and Planning is focused on the preparation of the organization of the E-ELT Project structure. Upgrade Path will pursue by design and prototyping the development of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Supramolecular Protective Groups Enabling Antibiotics and Bioimaging' to be submitted under Horizon 2020.

assistant: **Abstract**

The pharmaceutical sector has a huge demand for new active compounds including natural products to fill the drug pipelines and to stop the global decline in novel approved active pharmaceutical ingredients. Therefore, developing new tools to fabricate complex molecular structures in a fast and reliable way is paramount. This holds especially true for the field of antibiotics. Multidrug resistant (MDR) pathogens evolve at a terrifying rate and confer resistance to all presently available antibacterial treatments and therefore WHO has identified MDR bacteria as major threat to human health.In this ERC Advanced Grant, I propose a radically new approach to fabricate very complex molecules with minimal synthetic effort. The technology is based on nucleic acid binders (aptamers), which are evolved in a selection protocol and block several functional groups within a target molecule while allowing other functionalities not in contact with the aptamer to be selectively modified in a single reaction step. Here, we aim to establish this groundbreaking aptameric protective group (APG) method as a novel tool that gives access to compounds that would otherwise be too difficult to obtain by multistep synthesis.  Toward this end, the specific objectives are:•To develop reagents and reactions that are compatible with aptamer-mediated reactions•To control the site of chemical modification within complex molecules by APGs•To establish APGs as a general paradigm in natural product derivatization to modify several kinds of substrates•To achieve site selective modification of proteins by aptamers•To synthesize novel antibiotics that kill MDR bacteria•To fabricate “image-and-activate” antibiotics by the APG technology•To employ the aptamer-target complexes for live-cell imaging of RNAThe outc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Biodiversity impact assessment using species sensitivity scores' in the context of a Sixth Framework call.

assistant: **Objectives**

Biodiversity indicators and monitoring frameworks are currently developed at global and European levels. A key tool for monitoring progress in achieving the EU target to halt the loss of biodiversity by 2010 is the recently endorsed set of EU headline biodiversity indicators. A requirement by the EU is to complement the indicator set and the development of biodiversity monitoring frameworks with tools that are able to assess the impacts from Community policies on biodiversity in a cost-effective way. The BioScore project satisfies this requirement by developing a tool for linking pressures from policy sectors to the (change of) state of biodiversity as measured by the presence and abundance of individual species. The tool will contain information on the ecological preferences of individual species, in relation to individual sectoral pressures and relating to selected Community policies as well as the EU headline biodiversity indicators. This tool will be applied for assessing impacts and effectiveness of Community policies based on historic data as well as for forecasting future impacts based on existing scenario studies. The BioScore tool will be integrated into existing biodiversity monitoring frameworks and incentives for uptake will be formulated. Also the database will be made freely accessible on the Internet. The specific objectives are to: - assemble the necessary knowledge-base for developing the tool; - build a cost-effective impact assessment tool in the form of a European species database with sensitivity scores; - apply the tool for the purpose of assessing the impacts of key drivers and pressures on biodiversity; - apply the tool for analysing the effectiveness of European policy responses; - apply the tool for modelling European-wide scenarios for selecte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Quantum photonic chip' (QuanPhoChip) targeting Seventh Framework.

assistant: **Abstract**

Quantum technologies based on photons provide a promising path for building and using complex quantum photonic systems for both exploring fundamental physics and delivering quantum-enhanced technologies. While there have been impressive proof-of-principle demonstrations based upon on bulk optical elements, future technologies will require integrated optics architecture for improved performance, miniaturization and scalability. This project proposes to build a new class of quantum optics systems on a silicon chip. This integrated platform consists of integrated entangled-photon sources, high efficiency on-chip single-photon detectors and align-free quantum circuits to perform complex computing functions. This project will allow us to explore the forefront nanoscale quantum physics meanwhile simultaneously bring it to a practical engineering framework.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A new model for potato tuber initiation and yield development'.

assistant: **Objectives**

Tuberisation in potato is a major photoperiodic developmental programme in which stolons form starch-rich tubers. The earliness of tuberisation dictates the time to crop maturity and so is a crucial factor in potato agronomy. Exploitation of the naturally occurring variation in tuberisation onset provides a route to breeding improved varieties for different latitudes, harvest times and markets. Recent focus in this field has been on the regulation of a FLOWERING LOCUS T orthologue termed StSP6A, a positive regulator of tuberisation. These studies have facilitated development of tuberisation models. However, data from JHI and other literature suggest that these models are incomplete. Now work at JHI has identified a new player, a TFL-1 orthologue that appears to act as a negative regulator of tuberisation. The aims of POTENT are: to determine the binding partners and detailed expression pattern of TFL-1 in the stolon to develop a refined model of tuber initiation; to use a transcriptomic approach applied to TFL-1 transgenic lines to unravel tuber life cycle processes; to investigate the role of TFL-1 in tolerance to abiotic stress; to determine the combinations of StCDF1 and TFL-1 alleles possessed by potato varieties from different maturity classes, that impact on tuber initiation. The project will serve a training vehicle for the experienced researcher (ER) to enhance her portfolio of research skills, to restart her career and so increase her ability to innovate in this area of food security. The ER will add an extra dimension to current research activities in the host organisation by sharing her current expertise. Working with secondment partner Agrico UK, the outcomes will be of commercial and societal interest and a raft of measures will be taken to protect IPR and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Climate change and sea level.' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

To advance research into the basic processes that contribute to changes in the ocean volume with a changing climate. This involves the atmosphere, the oceans and the continental ice masses. The project can be divided into the four main contributors to sea level rise: thermal expansion, glacier and small  ice cap melt, the Greenland ice sheet and the Antarctic ice sheet.  Global mean temperature change and thermal expansion estimates from different O/AGCM experiments will  be compared using a simple energy-balance upwelling-diffusion climate model, which will be modified as  necessary. The regional distribution of thermal expansion due to ocean current changes will be estimated using  a limited area ocean circulation model of the North Sea.  Past and future glacier melt will be modelled using, for the first time, monthly mean regional temperature data  as the forcing and incorporating more comprehensive glacier data including results from new field work. The  modelling range from 3-D thermomechanical models of the whole ice sheets to more detailed regional studies.  The purpose is to assess the ice masses response to climate change.  New field work will be undertaken in both Greenland and Antarctica. Part of the project concentrates on  North-East Greenland because it appears to be the most active part of the ice sheet and therefore perhaps more  sensitive to climate change than judged hitherto: large iceflows feeding the outlet glaciers have been located  from the air. The field work will include an investigation of ocean, sea-ice, glacier interactions and the new  field data will be incorporated into a detailed 3-D modelling study of a North-East Greenland outlet glacier.  In Antarctica, it is intended to document the 20th century behaviour of ice discharge. This infor