RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Single-shot, ultrashort laser pulse characterization based on the dispersion scan technique' (SISHOT).

assistant: **Innovation**

Ultrashort laser pulses are prominent enabling tools in countless advanced applications, ranging from fundamental research to medical and industrial use. However, straightforward characterization of ultrashort laser pulses remains a nontrivial task. The proposed project (acronym: SISHOT) focuses on the development of advanced ultrashort laser pulse characterization based on the dispersion scan (d-scan) technique. We propose two d-scan implementations, named s-shot and d-shot, capable of characterizing ultrashort laser pulses in single-shot operation.Single-shot characterization techniques are particularly appealing because they can measure the temporal profile of individual laser pulses without artefacts, often originating from averaging. The proposed techniques can directly link the measured pulse parameters to the outcome of experiments for every laser shot as well as give immediate, real-time feedback to the adjustment and optimisation of any ultrashort pulse laser. In comparison to the competitors, our instruments are easier to use and the measurements are more intuitive to interpret.Within the project, the s-shot will be lifted from TRL4 to TRL7 and the d-shot from TRL7 to TRL9. We have identified the most important markets for ultrashort pulse characterisation. The s-shot will address the important scientific market at the laser wavelength of 800 nm and the d-shot will focus at the wavelength of 1030 nm, which is more relevant to medical and industrial applications.The project builds on the outcome of the previously funded ERC POC project, SISCAN. It is headed by Cord L. Arnold, assoc. prof. at Lund University in Sweden, and Rosa Romero, CEO of the deep-tech company, Sphere Ultrafast Photonics, located in Porto, Portugal. All team members have been working with th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Plastic litter in macrophyte system: environmental fate and ecological implications' in the context of a Horizon 2020 call.

assistant: **Objectives**

Plastic is an emerging environmental contaminant that attracts social, political, and scientific attention. However, the effect mechanisms and ecological conditions that promote the consequences of plastic littering remain elusive because of the single-species approach in ecotoxicological testing. To make regulatory decisions mitigating the problem, the potential impacts and vulnerable habitats must be identified. In aquatic ecosystems, macrophyte beds are often a templet habitat providing foraging grounds for pelagic and benthic food webs. These systems are also at the forefront of plastic littering, with high fragmentation and accumulation of microplastic. I propose to conduct a systematic study to understand the multiple interactions between the key components in a coastal habitat exposed to plastic littering. Using the keystone macroalgae species in the Baltic, Fucus vesiculosus, this project aims to evaluate the microplastic effect mechanisms that are related to the species interactions in seaweed beds, with a microbiome being the key component mediating these interactions as well as microplastic retention in the system. I will also investigate the potential of the macrophyte habitat as an entrance point for microplastic in the food web, with particular focus on the primary consumers with different feeding modes. To evaluate the ecosystem health posed by microplastics, the project will also examine effects of microplastic and their leachates on plant physiology, including its growth and metabolite production. Finally, I will evaluate the effects of microplastic exposure on the macrophyte templet functions, including energy transfer efficiency and heat wave resilience. This framework will provide an understanding of the pathways, fate and effects of plastic debris i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The control of protein synthesis in health and disease' in the context of a Seventh Framework call.

assistant: **Objectives**

Protein synthesis is a key process in living cells, being required for cells to grow, divide, and respond to changing conditions, as well as being critical in gene expression. However, protein synthesis in an expensive process, using a great of energy and amino acids. It is therefore tightly controlled. This involves the regulation, by phosphorylation, of proteins involved in protein synthesis (‘translation factors’) and mRNA-binding proteins. My laboratory studies the roles of these proteins and the protein kinases that act upon them in regulating protein synthesis in mammalian cells. I am particularly interested in the mTOR (mammalian target of rapamycin) pathway, which is regulated by amino acids and hormones and controls several steps in protein synthesis. A major goal of this project is to achieve a more complete understanding of mTOR signalling and to establish how different signalling pathways and translation factors work together to control protein synthesis. This research will extend our knowledge of a key biological process also help optimize production of biological drugs’, a major interest in the pharmaceutical industry. My laboratory also has a strong interest in the mechanisms by which defects in the translational machinery or in its control lead to human diseases. For example, dysregulation of mTOR signalling leads to cancer and heart disease. We will explore the molecular mechanisms involved in this. Defects in a key translation factor (‘eIF2B’) cause a severe neurodegenerative disease (‘vanishing white matter’). We will employ multiple complementary approaches to understand how problems in protein synthesis lead to these diseases. This will provide valuable information for treating or managing them. Lastly, faulty control of the synthesis of proteins ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Efficient QUantum Light for TechnologY'.

assistant: **Objectives**

Billions of consumers and thousands of companied depend on the security of network infrastructure to assure the safety of their data as it is bleamed around the world. At present, the security provided by traditional encryption algorithms depend on the fact that it takes a very long time for a traditional computer to solve the encryption that would reveal the protected data. However, advances in the domain of quantum computing and the development of efficient algorithms mean that it is becoming much easier to break down conventional encryption algorithms based on computational complexity. Quantum Key Distribution (QKD) networks aim to overcome this challenge by proposing secure lines of communication that have been encrypted using the fundamental laws of quantum physics. This is achieved through manipulation of physical properties of photons to encode information. However, many such networks remain expensive to set up and requires the support of a state-level entity, thus beyond the reach of consumers and companies. Furthermore, the transmission speeds achieved through current photon emitters remain relatively low, making transmitting complex data difficult. Quandela, a french SME founded in 2017 as a spin-off of the French Centre for Scientific Reseach (CNRS) proposes a revolutionary efficient emitter of single photons that would significantly increase the rates of information that could be efficiently transported through QKD networks. Thanks to a proprietary technology, Quandela's photon emitters are able to emit photons significantly more accurately and efficiently than the current products in the market. Quandela is specialized in building efficient chip-based quantum light sources. Due to its size and efficiency of photon emission, these chips could be easily integ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Breaking the penetration limit of microscopy – Photoswitching Optoacoustics' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

SWOPT is a novel imaging technology that will break through the penetration limits of optical microscopy to visualize individual cells and their function in vivo through several millimeters to centimeters of depth. SWOPT will exploit (1) optoacoustic imaging (OAI), a modality which combines signal generation similar to optical imaging with the whole-animal imaging capability of ultrasound readout, and uniquely augment it with (2) photoswitching to resolve signals from single labeled cells from deep within live tissue. This will achieve volume sampling abilities surpassing any optical microscopy by at least three orders of magnitude (> 5 x 5 x 5 mm imaging volume). SWOPT will develop the necessary breakthrough instrumentation and concepts: unique multiplexed diode illumination, novel ultra-wideband transducer technology, dedicated inversion algorithms that incorporate photoswitching in the three-dimensional reconstructions, and uniquely tailored classes of photo-switching transgene and synthetic molecular tools. The exceptional capabilities of SWOPT will be demonstrated by proof-of-concept work resolving cellular dynamics and functions in a whole tumor in a model of renal cancer in vivo. SWOPT builds on the world-leading expertise in the disciplines of OA imaging technology (Ntziachristos GER), applied mathematics (Unser CH), and cancer metabolism (Frezza UK) and is driven by excellent young researchers in protein-engineering (Stiel GER) and chemical synthesis (Szymanski NL) and supported by the science-to-technology focus of ambitious high-tech SMEs (Sonaxis FRA, iThera GER, Spear GER). SWOPT’s uniquely comprehensive, yet detailed imaging will enable examination of whole tissues in vivo with the same ease, flexibility and, eventually, abundance of tools paralleling fluo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Soft, Self-responsive, Smart MAterials for RoboTs', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The SMART Innovative Training Network is a joint venture between academia and industry, providing scientific and personal development of young researchers in the multidisciplinary fields of soft robotics and smart materials. SMART will realize the technologically and scientifically ambitious breakthroughs to exploit smart, stimuli-responsive material systems with actuation, sensing and self-healing capabilities for intelligent soft devices. This allows the soft robots to interact with dynamic and unknown environments in a smart fashion to avert catastrophic failure and reestablish structural integrity and operational functionality. Control intelligence enables interaction with the outer world and structural health monitoring allows the establishment of autonomous healing procedures, where upon sensing of damage or loss of functionality the system will cease operation and start a repair action, followed by the evaluation of the effective recovery of functionality and finally return to operation, thus expanding the service lifetime. These technologies will be integrated in fully functional and autonomous demonstrators to disseminate, benchmark and exploit the results. There is a need for future leaders with excellence in smart material systems and technologically advanced applications such as robotics and automation. The SMART ITN offers such multidisciplinary training by combining these two emerging fields with meaningful societal and economic impact (T-model). For this purpose, SMART brings together 8 beneficiaries and 11 partner organizations including 2 research institutes and 12 private companies, belonging to 7 EU member states, and to 2 associated states (Switzerland, Turkey). The consortium’s complementarity and multidisciplinarity will enable a top-level educatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Parasite risk assesment with integrated tools in EU fish production value chains' under Seventh Framework.

assistant: **Concept**

Despite many efforts to ensure that only high-quality and safe products are put on the market, fish-borne parasites continue to pose risks to human health, with zoonotic infections and allergic reactions mainly following consumption of raw, lightly cooked, or marinated seafood.The PARASITE proposal is presented by a multidisciplinary consortium of 12 European and 3 Asian research institutions and 6 European SMEs. It aims to provide new scientific evidence and technological developments to detect, monitor, and mitigate impacts of zoonotic parasites, mainly anisakid nematodes but also trematode metacercariae, occurring in European and imported fishery products. The Project will address the research needs identified by EFSA regarding the risk of seafood-borne parasites. It also will facilitate close cooperation between scientists and end-users to produce new technological solutions and management tools for both European and imported fishery products.The Work Plan has been organized in 9 work packages, each covering different stages of a risk assessment framework, providing new epidemiological data, monitoring tools, development and implementation of parasite detection devices, technological tools for their mitigation, and dissemination of key results to all the stakeholders and the general public.Risk assessment of zoonotic parasites will ensure significant progress beyond the state of the art. This will be achieved by improving molecular hazard identification, antigen/allergen characterization, parasite exposure assessment, detection methods and treatments for industrial and other end-users, and an integrated quantitative risk analysis based on powerful statistics and modelling,The main results will impact by (1) contributing to enhanced seafood safety, with consequent be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Prostate cancer integral management approach' (PRIMA) targeting Sixth Framework.

assistant: **Abstract**

In the European Union ~ 200.000 men will be diagnosed with prostate cancer and that number is likely to increase due to the aging population. If the disease is truly localized, patients can be cured by radical local treatment. However, if the malignant process has locally or distantly spread, no curative medical intervention is currently available.Since the early 1940-ties hormonal therapy has been the main stay in an attempt to control prostate neoplasms, but unfortunately this is only of palliative nature and tumour progression due to the expansive growth of cancer cells that are unresponsive to the currently available hormone therapies is inevitable. Prostate cancer has a strong tendency to spread to the bone, hence in order to combat the disease we have to explore the pathways that lead to hormone therapy unresponsive bone metastatic disease.It has become clear that in the majority of advanced prostate cancers the androgen receptor signalling pathway is active even in the absence of androgens. EC research teams have a leading role in AR research and will integrate their efforts to exploit androgen receptor mediated signalling as a therapeutic target. These teams will join forces with investigators that study the interaction between prostate cancer cells and the bone micro-environment. The exploration of the pathways leading to hormone therapy unresponsive bone metastatic disease will use functional genomics and expression profiling as technology platforms.These will also be used to identify new targets. This will ultimately lead to the establishment of assays to identify new (lead) compounds. These new drugs can be tested for their efficacy in models for bone metastatic prostate cancer; hence translation of our knowledge into therapeutic strategies will also be inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nanochemistry of molecular materials for 2-photon functional applications' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Nano2Fun's main target is the education of a new generation of scientists with a solid multidisciplinary scientific background, a good attitude to team-work in an international environment and a well-developed propensity to exploit advances in fundamental research towards innovative applications. To achieve this ambitious goal, a network of advanced research laboratories operating both in the public and private sectors is proposed where a group of 17 young and brilliant researchers will be trained through research.Technological development through research and knowledge transfer are the flag-words of Nano2Fun, a multidisciplinary project that will bring the techniques of two-photon microscopy (2PM) and two-photon polymerization (2PP) to their full maturity, allowing their exploitation in commercially and industrially relevant applications.The precise chemical and photophysical control of the 2PM and 2PP processes at the nanoscale will be achieved through a coordinated effort of 16 teams with well-established expertise in the diverse and complementary research fields of (a) molecular and supramolecular synthesis, (b) advanced optical spectroscopy and photophysics, (c) theory  and (d) the 2PM and 2PP technological applications. The effort of the academic research teams will be fully integrated with applied research and development going on in the advanced R&D laboratories of the 5 partners from the private sector in a virtuous loop that will cooperatively enhance the effectiveness of Nano2Fun team. The inherently multidisciplinary character of the research, that spans a full range of disciplines between chemistry and physics, and is precisely located where fundamental research meets commercial and industrial applications, offers an extremely profitable environment for the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Strange nuclear matter from first-principles hadron scattering amplitudes' under Horizon Europe.

assistant: **Concept**

StrangeScatt will assess the role of strange quarks in nuclear physics by performing first-principles computations of scattering amplitudes to study interactions between hadrons with strange quarks. The presence of strange quarks alters the properties of atomic nuclei and nuclear matter. For instance, the relationship between the mass and radius of neutron stars depends on the dynamics of strange quarks produced in their core. However, quantitative predictions of neutron star masses and radii are complicated by our ignorance of the fundamental interactions of baryons with strange quarks (hyperons). Such predictions are timely given the advent of dedicated neutron star observatories, multi-messenger astronomy, and earth-based experiments involving baryon resonances and nuclear matter.         Nuclear interactions are rooted in QCD, the fundamental force which binds quarks inside hadrons and hadrons inside nuclei. The bridge between few-body and many-body dynamics is made systematically with effective theories of the strong nuclear force, which require as input few-hadron scattering amplitudes as well as their quark-mass dependence. This project will compute two- and three-hadron scattering amplitudes between nucleons and hyperons directly from QCD using high-performance computer simulations on a space-time lattice.         Lattice QCD computations of scattering amplitudes have improved markedly thanks to algorithms developed by the PI, so that accurate and precise first-principles computations of are finally within reach. The unique ability of lattice computations to vary the up, down, and strange quark masses near their physical values is necessary for fully predictive effective theories. The PI's experience in lattice QCD computations of scattering amplitudes makes him