RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'HIDDeN - Exploring the Hidden Dusty Nuclei of Galaxies'.

assistant: **Objectives**

Luminous infrared galaxies (LIRGs) emit most of their bolometric luminosity in the far-infrared. They are mainly powered by extreme bursts of star formation and/or Active Galactic Nuclei (AGNs; accreting supermassive black holes (SMBHs)) in their centres. LIRGs are the closest examples of rapid evolution in galaxies and a detailed study of LIRGs is critical for our understanding of the cosmic evolution of galaxies and SMBHs. Centres of some LIRGs are deeply obscured and unreachable at optical, IR and even X-ray wavelengths. These hidden nuclei therefore represent a largely unexplored phase of the growth of central regions with their SMBHs. Large growth spurts are suspected to occur when the SMBHs are deeply embedded. Obscured AGNs thus can provide new constraints on the AGN duty cycle, give the full range of environments and astrophysical processes that drive the growth of SMBHs, and help to complete the picture of connections between the host galaxy and SMBH. Many dust embedded AGNs are still to be discovered as studies suggest that a significant fraction of SMBHs may be obscured in the local and more distant Universe. In the HIDDeN project we use mm and submm observational methods to reach behind the curtain of dust in the most embedded centres of LIRGs, allowing us to undertake ground-breaking studies of heretofore hidden rapid evolutionary phases of nearby galaxy nuclei. HIDDeN takes advantage of emerging opportunities to address the nature of near-field, and redshift z=1-2, obscured AGNs/starbursts and their associated molecular inflows and outflows in the context of their evolution and the starburst-AGN connection. In particular we use the ALMA and NOEMA telescopes, supported by JVLA, LOFAR, HST and future JWST observations, to address four interconnected goals: A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Deciphering the role of oxylipins in the epigenetic mechanisms controlling plant immunization.' under Horizon 2020.

assistant: **Concept**

Reducing crop losses caused by pests and diseases is absolutely necessary to feed the increasing world population, but the use of pesticides increases the damage to the environment and contributes to climate change. As a result, international entities such as the European Union are promoting the search for alternative strategies. Experts point to “plant immunization” or priming, as the safest and most effective approach to boost the endogenous plant immune system. Unfortunately, deeper knowledge of the involved mechanisms is needed for its application in crop protection. In this context, epigenetic mechanisms and oxylipin pathways are involved in priming processes but their specific contribution as well as the relationship between these two pathways has not yet been addressed. In order to fill this gap in our knowledge we propose an ambitious but feasible project that builds on solid and exciting preliminary results. We will use the unique genetic and molecular tools available in the model plant Arabidopsis thaliana to analyse first the role of oxylipin natural compounds in different priming processes and then, study the relationship between both molecular pathways to delineate plant defence mechanisms and priming. The synergistic interaction formed by the host group, world-leading in oxylipins research, and the applicant, an expert in epigenetics, guarantees the maximization of two way transfer of knowledge, training and networking possibilities. Moreover, this action has a potentially remarkable impact and represents a key point in the applicant´s career complementing her current knowledge and expanding her skills. Taking these considerations together, the EPILIPIN project offers a unique opportunity for the development of a research that perfectly fits the EU concern
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Order/Chaos: Genealogy of Two Concepts in the Culture of European Mathematical Physics' in the context of a Seventh Framework call.

assistant: **Objectives**

This project aims at understanding the generation of abstract concepts and theories in mathematical physics and their relation with theoretical practices. To achieve this, it focuses upon the emergence of the modern concepts of order and chaos in celestial and statistical mechanics. The research is articulated into three phases. The first phase discusses the problem of stability in a three-body system from the origin of celestial mechanics to Henri Poincaré’s discovery of homoclinic trajectories. Initially, the problem of stability was attacked by using analytical and algebraic techniques whose main goal was to show that approximate solutions of the equations of motion do not contain secular terms. Drawing on this vast culture of mathematical techniques and generalizing them further, Poincaré introduced a new qualitative approach, which led him to extend periodicity from periodic motion to complicate recurrence up to chaotic trajectories. The second phase focuses upon the intersections between mechanical and statistical arguments in the work of Ludwig Boltzmann. Facing the problem of dealing with mechanical systems with many degrees of freedom, Boltzmann combined the analysis of the equations of motion with statistical techniques which allowed him to describe the macroscopic behavior of the system. Thus, macroscopic order was understood as a probabilistic, long-term phenomenon deriving from a complex, microscopic disorder. Notions such as the ergodic hypothesis and molecular chaos were introduced by Boltzmann to conceptualize this disorder. The third phase concerns George D. Birkhoff’s path from the theory of dynamical systems to the ergodic theorem. Taking up Poincaré’s legacy in celestial mechanics in 1912, Birkhoff honed the analytical and topological techniques of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Open reading frames for the european union scientists (ORFEUS)'.

assistant: **Concept**

To manage large collections of proteins it is practical to store clones containing each corresponding Open Reading Frame (ORF) . From ORF clones, proteins can be synthesised in any cell type or expressed as translational fusions with any peptide moieties. Full ORF complements representing all proteins expressed in an organism (ORFeomes) are useful for many functional proteomics programmes. Their construction is now possible based on novel cloning techniques. Our objectives are(1) to create a European network of labs directly involved in the cloning of ORFs from human and model metazoan species, (2) to organise collaborative projects for the construction of comprehensive ORFeomes to improve the cost-effectiveness of European research funding and (3) to disseminate materials and expertise for the exploitation of ORF collections.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bootstrapping Time: Colliders, Shocks, Strings, and Black Holes' (KAIROS).

assistant: **Concept**

Two pillars of modern physics are Quantum Field Theory (QFT) and General Relativity (GR). Together they describe a vast corpus of phenomena ranging from the smallest scales accessible with modern accelerators to the largest distances observed with modern telescopes. Establishing these frameworks is a triumph of 20th-century physics.   Our understanding of both is not satisfactory. On the QFT side, we lack tools to analyze the strong coupling regime. On the GR side, we do not understand how to make it quantum. The insight of holography is that these two problems are deeply connected, in other words, QFT and Quantum Gravity (QG) are different realizations of the same underlying mathematical structure and physical principles. Providing us with this fundamental insight, holography does not tell us what the underlying structure is. The challenge for 21st-century physics is to understand it.    The aim of the present proposal is to establish a research team at CERN that: a) will {\it develop new nonperturbative Lorentzian bootstrap methods} as a part of a larger quest of revealing the unifying mathematical structure and physical principles that underlie both QFT and QG; b) use these methods for state-of-the-art {\it computations of  real-time physical observables} which are not accessible using conventional methods. This will lead to new insights into the fundamental properties of QFT, QG, and holography which relates the two. The principal novelty of the project is in its focus on the nonperturbative real-time dynamics, as opposed to Euclidean observables which are typically studied using the current bootstrap or other methods.   Bootstrap takes fundamental principles of physics, such as causality, locality, and unitarity, and pushes their consequences to the extreme. Combin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dissecting Multivalent Viral Receptor-carbohydrate Interactions Using Polyvalent Multifunctional Glycan-Quantum Dot' to be submitted under Horizon 2020.

assistant: **Abstract**

Multivalent lectin-sugar interactions play a key role in facilitating viral infections, affecting hundreds of millions people worldwide. Understanding the structural mechanisms is key to be able to design glycoconjugates that can block such interactions, thereby preventing infection. However, research advances have been hampered by inability of current methods to reveal key structural information of some important cell surface lectins. For example, despite 17 years of extensive research, the structure of two vitally important tetrameric lectins, DC-SIGN and DC-SIGNR, remain unknown. These lectins bind to virus surface multiple glycans and enhance many viral infections (e.g. HIV, HCV and Ebola).This fellowship will address this challenge by developing a novel multimodal readout strategy (e.g. FRET, TEM and particle size analysis) using compact polyvalent glycan-quantum dots (QD) to fully exploit multivalency and QD’s unique properties. By tuning QD surface glycan structure, valency, inter-glycan spacing and flexibility, we will create a perfect spatial & orientation match to those of glycan-binding-domains (CRDs) in DC-SIGN/R, leading to greatly enhanced binding affinity. By studying QD-glycan binding with DC-SIGN/R, we will reveal key structural data (e.g. CRD orientation, distance, binding mode) in DC-SIGN/R. We will verify the binding data with native receptors on cell surfaces, correlate receptor binding affinity with virus inhibition potency, and study their immune cell activation.This research is extremely timely and important because it will, 1) address the capability gap of current methods; 2) reveal key structural information of CRD spatial arrangement in DC-SIGN/R; 3) reveal how ligand multivalency & affinity control intracellular trafficking and modulate dendr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'From Isolated Compartments to Intracellular Networks: Deciphering Interorganelle Communication' (OrgaNet) under Seventh Framework.

assistant: **Objectives**

Organelles exchange metabolites and information to coordinate essential aspects of cellular physiology, thus behaving as an integrated intracellular network. For example, the endoplasmic reticulum (ER) makes contacts with several organelles, including the plasma membrane, mitochondria, the Golgi apparatus, and lysosomes. These contacts allow the coordination of calcium and lipid homeostasis across the cell. Yet, little is known about their molecular nature. A long-standing question in cell biology has been how membrane-rich mitochondria receive lipids synthesized in the ER in the absence of vesicular transport between the two organelles. One model suggests that lipids directly shuttle from one organelle to the other at sites of contact, although the hypothesis lacked molecular details.A breakthrough in the field resulted from my postdoctoral research in Peter Walter's laboratory, where I discovered a protein complex that tethers the ER and the mitochondria. This tethering complex called ER-Mitochondria Encounter Structures (ERMES) provides the tethering force necessary to physically couple the two organelles. Our discovery of molecular components of ER-mitochondria junctions opened a fascinating new area of research in interorganelle communication. Our long-term goals for ER-mitochondria study are to understand: (a) the physiological importance of these connections, how they facilitate interorganelle metabolite transport and how this transport affects the functionality of the respective organelles, (b) the molecular architecture that results in interorganelle tethering, (c) the regulation of these junctions, and (d) the conservation between yeast and higher eukaryotes.As most membrane bound compartments establish networks of contact sites with their neighbors, we antici
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Breast Milk Biomimetic Nano Particles as a Versatile, Non-Invasive, Oral Drug Delivery Tool' (MILKOSOMES).

assistant: **Concept**

We propose to use human breast milk cells to engineer breast milk biomimetic nanoparticles (NP), “MILKOSOMES,” to shuttle medicines orally into the body that, under other conditions, would not be able to distribute properly. MILKOSOMES are cellular membrane protein-functionalized phospho-lipid NP (i.e., liposomes), and they are hypothesized to cross the gastrointestinal (GI) tract while protecting their therapeutic cargo and serve as a novel way to improve oral therapy outcomes. Unfortunately, although oral delivery of therapeutic agents is the most patient-preferred route of administration because it is painless and convenient, it entails enormous challenges. Specifically, large molecules, such as messenger RNA and proteins, cannot be delivered orally due to their chemical and enzymatic degradation in the GI tract and poor intestine's permeability to these molecules. Interestingly, cells, which are a thousand times bigger than these large molecules, remain intact. Therefore, they can get out of the GI tract due to membrane protein-mediated biological processes and make their way into our bodies. Herein, we aim to: (1) Identify and assess the breast milk cell populations which cross the GI tract into the infant body after breastfeeding in vivo, (2) Fabricate and characterize MILKOSOMES, (3) Evaluate MILKOSOMES’ ability to cross the GI tract biological barrier using in vitro and ex-human models, and (4) Test MILKOSOMES’ therapeutic efficacy in vivo using two diverse in vivo models. Thus, we will harness the specific and unique biological function of these GI tract-crossing native cells while protecting their therapeutic cargo from degradation using the phospho-lipid NP backbone. Our findings will increase our fundamental understanding of cellular and NP trafficking throu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evaluation of species-specific ebolavirus pathophysiology in xenochimeric mice', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Ebolaviruses comprise five virus species of which at least three are highly pathogenic for humans. Other mammalian species such as non-human primates, forest antelopes and pigs are susceptible to ebolavirus infection with different degree of severity. However, bats and laboratory mice are entirely resistant to ebolaviruses. Why do ebolaviruses cause severe disease in some species but not others? This question, which is paramount to understand ebolavirus pathogenesis is the central question of our proposal. To address it, we will build on technology developed by the host laboratory to develop xenochimeric mice, that is, severely immunodeficient mice whose hematopoietic system has been replaced with another from a donor species (e. g. bats, monkeys or humans). This novel in vivo system will allow us to investigate the kinetics of ebolavirus infection across species and to dissect the mechanisms responsible for pathogenicity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of an advanced indentation testing system for mechanical properties by diamond indenters with electrically conducting surfaces' (1994-1998).

assistant: **Innovation**

Objectives and content A new type of instrument for mechanical testing, the Nanoindenter, was developed in the late 80's, as a spinoff of the scanning tunnelling microscope. This instrument allows high precision measurements of the penetration depth of a diamond indenter into the test material as function of the load, usually two curves for the loading and the unloading cycles are recorded, from which hardness, elastic modulus, toughness and many other properties can be derived. The demand of this new type of mechanical testing on industrial products is strongly increasing. However, its use is limited due to the fact, that only samples of restricted size can be tested. Larger samples from industrial equipment have to be cut in small pieces, which fit into the instrument. The instrument, as it exists to-day, is extremely sensitive to vibrations, and has to be mounted in vibrationally damped environments. The goal of this project is to develop a portable instrument for testing metallic and other electrically conductive materials. In contrast to the classical nanoindenter, the new instrument will determine the depth of penetration by measuring the electrical resistivity between the indenter and the testpiece. For this purpose the surface of the indenter will be coated with a thin doped diamond layer, or an electrically conductive ultrahard ceramic coating. Due to its measuring principle, the instrument will not be influenced by vibrations and can be built as a hand-held device allowing measurements to be performed on large test pieces and on sites which are not accessible by conventional instruments. Mechanical testing on site is especially important for pieces which are relevant for the safety of industrial installations as power plants and chemical plants, and in the pub
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Participation and Representation in the Digital Age: Participation Repertoires in an Era of Unequal Representation' in the context of a Horizon Europe call.

assistant: **Objectives**

This project addresses the question of how people incorporate increasingly prevalent nonelectoral political acts into individual-level repertoires of participation; and how well represented these different types of political participators are. At a time of growing concern about unequal representation in democracies, two conflicting global trends over the last several decades highlight the importance of these questions: a clear decline in voter turnout, especially among lower status groups; and evidence of increased nonelectoral participation, especially among higher status groups. To assess how these trends in political participation affect patterns of representation, PRD’s theoretical framework integrates new approaches for investigating the links between individuals’ participation repertoires (i.e., how individuals combine voting, protest, online activism) and objective and subjective representational outcomes.PRD’s work packages employ a multi-method approach: “Political acts and political participators” (WP1) analyzes separate surveys and a harmonized dataset and includes methodological innovations using new techniques for identifying participation repertoires. “Participation-representation connection” (WP2) investigates the connections between the political acts and political participators analyzed in WP1 and representational outcomes, and integrates these findings with qualitative fieldwork with activists who focus on unequal representation. Finally, “Mobilizing and organizing low-status groups” (WP3) conducts novel experimental studies using Twitter panel data and field experiments to identify interventions with the potential to produce more equal representational outcomes in the future. By combining an original theoretical framework and methodological innovation