RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Perturbed evolution of binaries and multiples' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

I propose a research program with a focus on the evolution of binaries and multiples in dense stellar regions. The study will be applied to the objects formed in a dynamical encounter which are frequently observed in dense stellar systems, and can be studied only using a combination of different techniques, most importantly stellar dynamics, stellar evolution, population synthesis and hydrodynamics. The project will address the following immediate challenging problems: - Young massive clusters: signature of dynamical processes - Intermediate-mass black hole: validation of two formation scenarios. - Close binaries: formation of binaries through physical collisions and interacting triples. - Comparison of the primordial and collisional populations of blue stragglers. The long term target of the project is to develop a complete hybrid code, which should involve simple stellar evolutionary prescription for unperturbed stars, a precise stellar evolution calculation for single or binary stars that were perturbed by encounters, as well as a hydrodynamic simulation to perform physical collisions. Hybrid methods are an emerging branch of stellar systems modelling, but it has been often observed that they are absolutely crucial for further progress and hence would provide a milestone for the research and benefit the entire astronomical community. The short term goal is to study the most important perturbing effects and combine the approaches systematically and consistently.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Synthesis of the manumycin family of antibiotics and novel ras farnesyl transferase inhibitors for cancer chemotherapy' (1994-1998).

assistant: **Concept**

Inhibitors of the Ras farnesyl transferase (FTPase) enzyme have recently been shown to possess great potential as anti-cancer agents, particularly for colon and pancreatic carcinomas. Members of the manumycin family of aminoepoxycyclohexenone antibiotics act as potent and selective inhibitors of FTPase but these complex natural products seem to be too inaccessible and unstable to be useful chemotherapeutic agents. However, there is good evidence that synthetic aminoepoxycyclohexenones could be designed with the necessary stability and accessibility, while retaining the desirable biological properties. No synthetic approaches to manumycin analogues have been reported but preliminary studies in York have developed suitable methodology. The overall aim of this proposal is to extend this chemistry, and to develop chiral modifications, in order to prepare the natural products, and simplified analogues, for biological screening. Novel chemistry includes organometallic coupling reactions, the use of chiral acetals and Lewvis acids, and the stereocontrolled synthesis of complex polyenes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European conference on human and veterinary pharmaceutical products in the aquatic environment: fate, effects and regulation : knowledge and future needs.' to be submitted under Fifth Framework.

assistant: **Abstract**

The proposals aims to organise a European conference devoted to the problem of human and veterinary pharmaceuticals in the environment. This initiative is taken into close relationship with three on-going European projects dealing with the fate and the effects of these products in aquatic and terrestrial environment as well as the removal technologies. European and non-European scientists end-users, industrials and regulators will be invited to present their works in these fields. The Conference will be held in Lyon, France, at the end of December, and should be an important opportunity to define the future new areas of investigation necessary to improve the environmental risk assessment of the pharmaceuticals, and their removal, and to prepare a network of excellence on this topic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Categorical Model theory, Stability theory and applications' (CatModStab), addressing dissemination and exploitation.

assistant: **Impact**

Model theory traditionally studies mathematical structures (models) which can be characterised by first-order logical axioms (a theory). However, a number of important mathematical concepts do not fit in this framework, so researchers have been increasingly interested to generalize successful techniques of model theory to other frameworks, such as continuous logic, positive logic and a very general category-theoretic approach. One of the deepest parts of model theory is stability theory, which has inspired a great deal of research with countless applications, even when limited to the traditional first-order framework. Stability theory can be studied through independence relations that tell us which parts of a given structure are related, and which are not. Such independence relations work especially well in the stable, simple and NSOP1 settings, which relate to the complexity of the structures involved. Modern formulations of independence relations allow for a clear translation to categorical language.We propose to build on pioneering work to generalize stability-theoretic tools for the simple and NSOP1 settings to the categorical framework. This overarching goal is split up in three objectives.(O1) Develop categorical independence, primarily in the unstable settings.(O2) Establish novel approaches to the long-standing stable forking conjecture.(O3) Found an enriched model theory and stability theory through enriched categories.This ambitious generalization will be achieved by combining my experience in modern model theory and stability theory, with the complementary expertise of my supervisor, John Bourke, and my advisors, who are world-leaders in categorical model theory and other categorical aspects relevant to this project, such as enriched category theory. On an in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Beyond Thalidomide: The Patient as an Agent of Change', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Beyond Thalidomide will trace the historical rise of patient engagement with drug related disability through the second half of the twentieth century to understand how a novel empowered group transformed conceptions of (reproductive) health and disease in science and society. The project will map the conditions in which patient became engaged with antenatal drug use, and reconstruct how their action has created political and scientific urgency since 1960. This multifaceted engagement resulted in clashes of expertise that connected actors in the Global South and North, from Latin American countries through Central Africa, India, and Europe, and the enforcement and stabilization of the development of approaches in reproductive health in the light of the democratic and civil societal challenges they pose, beyond traditional accounts of expert-led, iatrogenic risk management.BT will address these aims trough analysis of four interlinked fields of patient engagement:1.Monitoring, and the surveillance of exogenous factors for birth defects2.Prevention, and the management of risks of antenatal drug use in health care systems3.Marketing, and the making of pharmaceutical products4.Legal Action, and court intervention Mapping these fields of acting, BT will create an ambitious digital collection of patient life stories and a comprehensive integrated record of how patients engage. BT will, or the first time, deliver a global history of drug related disability from below, which examines the shifting contours of patients as actors. This project takes a ground-breaking approach to the historiography of reproductive health, combining high-impact global case studies with innovative research tools to explore the political, ethical and social challenges of this alternative perspective.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Smart Toolbox for Engaging Citizens into a People-Centric Observation Web' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Whilst citizen participation in environmental policy making is still in its infancy, there are signs of a growing level of interest. The majority of citizens, though, both as individuals and as groups often feel disengaged from influencing environmental policies. They also remain unaware of publicly available information, such as the GEOSS or Copernicus initiatives. The SCENT project will alleviate this barrier. It will enable citizens to become the ‘eyes’ of the policy makers by monitoring land-cover/use changes in their everyday activities. This is done through a constellation of smart collaborative technologies delivered by the SCENT toolbox in TRLs 6-8: i) low-cost and portable data collection tools, ii) an innovative crowd-sourcing platform, iii) serious gaming applications for a large-scale image collection and semantic annotation, iv) a powerful machine-learning based intelligence engine for image and text classification, v) an authoring tool for an easy customization by policy makers, vi) numerical models for mapping land-cover changes to quantifiable impact on flood risks and vii) a harmonization platform, consolidating data and adding it to GEOSS and national repositories as OGC-based observations. SCENT will be evaluated in two large scale demonstrations in Kifisos Attica and Danube Delta. Our consortium covers the complete stakeholder chain: industries in machine learning (IBM), SMEs in crowd-sourcing (U-Hopper), gaming (Xteam) and awareness raising (Carr), leading research institutes with expertise in hydrodynamic modelling (UNESCO-IHE), data harmonization and authoring tools (ICCS) and environmental monitoring (DDNI), NGOs at the pilot sites (HRTA, SOR) and policy makers/public bodies (Region of Attica). The SCENT initiative will go beyond the current proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Single metal nanoparticles as molecular sensors' (SINGLESENS), addressing dissemination and exploitation.

assistant: **Impact**

Optical spectroscopy of single plasmonic nanoparticles (NPs) has evolved into a recognized tool for nanoscopic sensing applications, using the sensitivity to the NP's environment,charge, size, shape, and proximity to other NPs. Here, I propose taking advantage of the nanoparticle s minuscule size approaching molecular dimensions in novel ways. Single particle plasmon sensors are in many ways the smallest possible giving unprecedented access to molecular events. The small size amplifies fluctuations by molecular events, allows massive parallel detection of analytes within tiny devices, and to monitor single nanoparticle formation and electrochemical surface reactions in real time.The objective of this project is therefore to develop and explore single-particle plasmon spectroscopy as a novel tool to study such molecular processes. The objective will be reached by (1) building three new setups progressing far beyond current technology and increasing time resolution, spectral sensitivity, and parallelization capability many orders of magnitude, (2) synthesizing nanoparticles with optimal plasmon sensing properties, and (3) simulating plasmon properties to guide the experiments and understand the physics behind the observed phenomena. The single-particle plasmon spectroscopy technique will be applied in four scientific directions to demonstrate its potential: (4) analyzing distance fluctuations of particle pairs linked by (bio-)polymers, (5) recording coverage fluctuations of biomolecules bound to nanoparticles, (6) demonstrating parallel detection of many analytes in multiplexed microfluidic devices, and (7) following particle formation and chemical reactions in a  single particle reactor .Single-particle plasmon spectroscopy has the potential to provide a revolutionary ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Electronic AXONs: wireless microstimulators based on electronic rectification of epidermically applied currents' in the context of a Horizon 2020 call.

assistant: **Objectives**

To build interfaces between the electronic domain and the human nervous system is one of the most demanding challenges of nowadays engineering. Fascinating developments have already been performed such as visual cortical implants for the blind and cochlear implants for the deaf. Yet implantation of most electrical stimulation systems requires complex surgeries which hamper their use for the development of so-called electroceuticals. More importantly, previously developed systems based on central stimulation units are not adequate for applications in which a large number of sites must be individually stimulated over large and mobile body parts, thus hindering neuroprosthetic solutions for patients suffering paralysis due to spinal cord injury or other neurological disorders. A solution to these challenges could consist in developing addressable single-channel wireless microstimulators which could be implanted with simple procedures such as injection. And, indeed, such solution was proposed and tried in the past. However, previous attempts did not achieve satisfactory success because the developed implants were stiff and too large. Further miniaturization was prevented because of the use of inductive coupling and batteries as energy sources. Here I propose to explore an innovative method for performing electrical stimulation in which the implanted microstimulators will operate as rectifiers of bursts of innocuous high frequency current supplied through skin electrodes shaped as garments. This approach has the potential to reduce the diameter of the implants to one-fifth the diameter of current microstimulators and, more significantly, to allow that most of the implants’ volume consists of materials whose density and flexibility match those of neighbouring living tissues f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The effect of international ties on launch sequence and launch pricing decisions in the pharmaceutical industry'.

assistant: **Innovation**

The aim of this project is to examine how companies go about launching innovations worldwide. Launch is the commercialization of a product i.e. the moment at which a new product enters a market/country for the first time. We focus on innovation in the pharmaceutical industry context as these innovations are new medicine. Examining commercialization is particularly relevant in the context of pharmaceuticals as, more than in any other industry, different launch timings/sequences mean different levels of access to medicine for society, which can be accompanied by a decrease in life quality or even death, dependent on the severity of the disease. With regard to launch, we are interested in drivers of the launch timing or more specifically, the launch sequence. The launch sequence represents the order in which new drugs are launched into the global marketplace (for example the European Union). In addition to the launch sequence, we are also interested in knowing the drivers of the launch price. The launch price is essential because it determines both patients’ access to medicine and it determines a nation’s health expenditures. An important characteristic of the pharmaceutical industry is the regulatory environment. Even within the European Union, a lot of differences exist with regard to regulatory regimes (Stremersch and Lemmens 2009). One particularly relevant regulation within the European Union (but also in other countries in the world) is the cross-country reference pricing system (external referencing). This entails that the launch price in one country is dependent on the launch prices in other countries. Public policy makers in every single country decide whether they oblige companies to look at launch prices in other countries. In addition to geographic, economic, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Evolution of Planktonic Gastropod Calcification' in the context of a Horizon 2020 call.

assistant: **Objectives**

Calcification by marine organisms can be drastically affected by ocean acidification (OA) due to a reduced availability of calcium carbonate in seawater. Planktonic gastropods (pteropods and heteropods) are believed to be among the most vulnerable organisms to OA as they live at the ocean surface and build thin shells of aragonite. Shelled pteropods have received considerable attention and are reported to decrease calcification rates and experience shell dissolution under high CO2 conditions. Shelled heteropods have received much less attention, but are expected to be equally vulnerable. However, the vulnerability of planktonic gastropods is based on short-term exposures to extreme OA conditions. The aim of the proposed project is to study the evolution of calcification in planktonic gastropods and assess its evolutionary potential under OA. Planktonic gastropods build shells through a biomineralization process, controlled at the molecular level, but the genes underlying this process are unknown. Using shell proteomics will enable to identify for the first time the biomineralization genes in pteropod and heteropod species. Next, these genes will be used to understand how biomineralization evolved in the two independent plankton groups over long and short timescales. Over long timescales will include building solid macro-evolutionary frameworks using fossil-calibrated phylogenomic trees and analysis of the evolution of biomineralization genes. Over short timescales will involve studies at the population-level by measuring gene expression under past, present and future concentrations of CO2. The proposed action will allow the discovery of new molecular markers to investigate the impacts of OA. Combining macro- with micro-evolutionary approaches will shed light on the proc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Microbial production of native and recombinant tailor-made enzymes for fine chemicals production', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

This project represents an integrated approach to take benefit of the cell factories to the development of a class of key processes and products in the pharmaceutical and fine chemicals industries: enantiomerically pure compounds. The main goal of this project is the microbial overproduction of native and recombinant tailor-made lipolytic enzymes from Candida rugosa and Rhizopus oryzae to be employed, as catalyst, in target reactions of interest for the production of asymmetric fine chemicals and pharmaceutical intermediates (enantiopure compounds). The project is focused on a multi-disciplinary vision to integrate biological and biochemical engineering interpretation of cell factories activity as the optimum way to produce higher and specific, reproducible and sustainable quality products by biological systems. The final objective is the optimization of the whole process, from genetic and protein engineering, fermentation and downstream processing to biotransformations, to produce the best tailor-made enzyme for the target reactions. The project will be based on advanced techniques of bioprocess engineering, ranging from on-line monitoring to optimal control, making use of commercial or specially designed instruments, mathematical estimation of variables not measurable on-line, studies on cell physiology, as well as tools of metabolic engineering, mathematical modelling and artificial intelligent techniques in order to maximize yields and to have perfectly well characterised tailor-made enzyme production. Fermentation process will be integrated with downstream processing to obtain a highly purified enzyme. Enzyme engineering will design adequate enzyme derivatives and their kinetics will be characterised to make an accurate evaluation of each tailor-made enzyme in aque