RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Thermoplastic Hydrogen tanks Optimised and Recyclable'.

assistant: **Concept**

THOR aims at developing a cost-effective thermoplastic composite pressure vessel for hydrogen storage both for vehicle and for transportation applications. Thermoplastics appear as a promising solution to the challenges faced by conventional tanks in terms of compatibility with hydrogen service and with mass automotive market requirements. The use of thermoplastic materials, advanced numerical modeling techniques and innovative manufacturing processes will boost the performance, improve safety, enable optimized tank geometry and weight (reduction of 10%) and reduce the cost for mass production (400€/kg of H2 stored for 30 000 tanks/year). A series of tests extracted from demanding automotive standards will validate all the requirements and demonstrate that thermoplastic tanks outperform thermoset ones. The consortium is representative of the hydrogen supply chain, from technology developer to manufacturer and end-user enhancing market uptake: a disruptive technology provider with successful commercial experience of thermoplastic tanks (COVESS), an ambitious Tier One supplier targeting a wide market introduction towards all OEMs (FAURECIA), an industrial gas expert with a long history related to hydrogen and a complementary end-user of tanks for hydrogen supply and refueling station operations (AIR LIQUIDE). This core industrial team is limited in purpose to avoid possible future commercial conflicts of interests and backed up with top research expertise to address all the identified challenges: an innovation center for material research with important tank scale testing capacity (CSM), a technology center in the fields of composite materials, manufacturing, automation, and testing (SIRRIS), academic teams with strong experience of composite materials and non-destructive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mapping the late-life health promoting mechanisms in worms and mammals' (LATELIFEHEALTH) targeting Seventh Framework.

assistant: **Abstract**

Aberrant protein aggregation (proteotoxicity) is an underlying mechanistic event common to numerous late-onset human neurodegenerative maladies including Alzheimer’s (AD) disease. Recent studies indicated that the ageing process plays key roles in enabling protein aggregation to become toxic late in life. The insulin/IGF signaling pathway (IIS) is a major ageing, stress resistance and lifespan regulator in worms and mice. We found that IIS reduction protects worms and mice from toxicity associated with the AD linked peptide, Aβ. These findings point to the alteration of ageing by IIS reduction as a promising research avenue towards the development of neurodegeneration therapies. In the nematode C. elegans, both effects of IIS reduction; longevity and protection from proteotoxicity are dependent on the activity of the FOXO transcription factor DAF-16. However, these functions of DAF-16/FOXO differ temporally; in worms the mediation of longevity by DAF-16 is restricted to reproductive adulthood while protection from proteotoxicity extends also to late adulthood. This differential temporal activity pattern suggests that different DAF-16 co-factors and target genes play roles in the mediation of longevity and in protection from proteotoxicity. Thus, a careful characterization of the late life DAF-16 regulated protective mechanism is required to evaluate the therapeutic potential of IIS reduction as a future treatment for neurodegenerative disorders. Here I propose to use nematodes and mice to explore the DAF-16/FOXO co-factors and target genes that mediate stress resistance and protection from proteotoxicity in the aged organism. Dual experimental approach will be utilized to achieve this goal; a directed genetic screen for the identification of co-factors and temporally di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Epigenetic Glioblastoma Therapeutics' (EpiGlioT).

assistant: **Innovation**

The goal of this project is to develop a successful treatment that combats the progression of glioblastoma and improve patients’ quality of life. Glioblastoma, the most malignant brain tumour, leads to disproportionately high morbidity in patients and impacts the economy through high mortality rates. The available treatment options are highly ineffective and pose a significant challenge to the healthcare budgets of all nations.Beactica aims to address this challenge by developing novel compound to inhibit the overexpressed in cancers protein LSD1. Beactica’s programme is based on a verified LSD1 knockdown technique and proves markedly more effective with glioblastoma clones that are resistant to other therapeutics. This way, Beactica’s compounds effectively clear cancer cells from which brain tumour might grow anew and will reduce the risk of relapses. This therapy will improve intervention outcomes for patients and lower additional treatment and healthcare costs including longer hospitalisation and further medical procedures. This programme is unique and there are no competitors using the same approach to treat glioblastoma by knockdown of the LSD1 protein with a small molecule. The ultimate success of this project will depend on the generation of clinical data which will improve opportunities for out-licensing. Beactica plans to apply for SME Phase 2 grant to take the lead compound through the clinical Phase I/IIa, and then reach the pharmaceutical market by an agreement with a strong licence partner. Beactica has an established business development contact network and has already gained trust of external investors in this innovative technology.The problem of cancer is growing dramatically and has been highlighted in the recent policy focus by the European Commission
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Intelligent distributed process utilisation and blazing environmental key' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

In several industrial processes a misuse of resources prevails that drastically could be reduced introducing smart ICT-tools allowing real-time traceability solutions. One rather spectacular application concerns the forestry-wood production chain where proper raw material for specific final products is an unsolved problem due to the complexity of biological raw-material in industrial processes. The magnitude of the problem, based on estimation of the total production of sawn wood in Europe 2002, is 25 million m3 equivalents to 5 billion euro. The Indisputable Key aims at developing methodology, technology, and knowledge to enable a significant increase in the utilisation of production resources in the forestry-wood production chain and to decrease the environmental impact.The developed systems will be based on the Individual Associated Data (IAD) concept, which facilitates automatic tracking of data along the forest-wood chain. Parameters involved, e.g. breast height diameter class, log number in the stem and cutting date strongly influences final wood product quality. Making information available at different stages along the forestry-wood chain requires automatic traceability systems, starting with logs in the forest. Communication between systems requires advanced information technology involving RFID-transponders and cellular phones adapted to industrial use by increased functionality. Frontline mechatronics, software, nano mechanics and electronics RandD partners will develop these systems.Verifying the function and environmental effects of the Indisputable Key systems will be implemented in different nodes of the forest-wood production chain by high-tech developers and evaluated by world-leading industry groups and fore-runner SMEs at hardwood and softwood forest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Effect of sublethal thermal injury on the survival and re-growth of Salmonella enteritidis. Model development and application to eggs products' to be submitted under Seventh Framework.

assistant: **Abstract**

The European Food Safety Authority and the European Centre for Disease Prevention and Control have published their Community Summary Report on Food-borne Outbreaks in the EU in 2007 and it shows that Salmonella remained the most common cause of food-borne outbreaks. In particular Salmonella enteritidis in eggs has been identified as a major cause of outbreaks. It has been recommended that eggs used in raw or minimally processed foods should be “commercially treated”, usually meaning inactivation by heat treatment. The treatment severity has to be low, in order to minimise the damage to the functional properties of the egg. Whilst the enforcement of this recommendation has helped to reduce the number of cases of Salmonella infections, the kinetics of the recovery and possible growth of Salmonella after heat treatments has not yet been quantified satisfactorily. A well-established and verified mathematical model would be especially important in cases where the heat treatment fails or where the food is cross-contaminated. The predictions generated by the model could be integrated into microbiological risk assessments. The project output would also help to improve the general understanding of the recovery process of bacteria injured by heat treatments.The purpose of this project is to model the survival and re-growth of Salmonella enteritidis after mild heat treatments. A mathematical model will be developed based on experiments in broth. It will be adapted to egg products, while bearing in mind that the medium has a significant influence on the recovery of injured cells, for which not all factors are known. The modelling will take into account: the probability of growth in the recovery medium which will depend on the treatment and environmental conditions; both the effect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Adjoint-accelerated Inference and Optimization Methods' under Horizon Europe.

assistant: **Concept**

The proposed research will demonstrate, with industrial examples, how scientists and engineers can efficiently combine data with prior physical knowledge. It will leverage Bayesian inference for rigour, adjoint methods for speed, and fluid dynamics for impact. Bayesian inference has been applied to fluid dynamics before but rarely using adjoint-accelerated inference and optimization methods (AXIOMs). These methods are crucial for practical applications because they dramatically accelerate data assimilation, especially when models contain thousands of parameters. This produces quantitatively-accurate physically-interpretable models that extrapolate successfully in directions in which the physics holds. Furthermore, they quantify the information content of data and rank physics-based, physics-agnostic, and combined models by calculating their relative likelihoods given the data. The proposed research will exploit AXIOMs to achieve a 10 times reduction in scan time of Flow-MRI (Magnetic Resonance Imaging) compared with state-of-the-art compressed sensing, transforming the accessibility of clinical Flow-MRI. This research will achieve a similar increase in the extractable information from experimental campaigns on gas turbine rigs, increasing reliability and reducing cost in a crucial European industry. It will also infer the rheometry of opaque fluids from a single Flow-MRI image, rigorously select the most appropriate turbulence model from data, and improve the robustness of widely-used model discovery algorithms. This project will encourage researchers to consider data in terms of information content rather than file size, enable the use of physics-based models alongside physics-agnostic models, and contribute to other areas in physical science through engagement with th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'An environment for better health' to be submitted under Fifth Framework.

assistant: **Abstract**

A European conference An Environment for Better Health" will take place in Airbus, May 2003. The conference is organised by a steering group that has been appointed by European Science Foundation (ESF), WHO Europe and the Danish Centre for Environment and Health, Ministry of Interior and Health. The conference will be open for scientists and administrators in the area of environment and health, and will consist of plenary sessions, keynote lecturers and group discussions. Invited papers will review European research activities in the priority areas identified by the ESF programme "Environment and Health Research for Europe", that were presented at the 3rd. Ministerial conference on Environment and Health. This will be supplemented by presentations of ongoing EC-supported projects. A summary report will be submitted for presentation at the 4th. Ministerial conference, Budapest 2004."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'GMES In-Situ Coordination' (GISC) under Seventh Framework.

assistant: **Objectives**

The EEA GMES insitu coordination proposal will contribute to the preparation of future community policies, specifically the management of in-situ data as described in the Commission Communication. It is unlike most of the projects in the Framework 7 Space Programme in that it focuses on management issues, but it nevertheless embodies all the elements of innovation, impacts, and a sustainable legacy that goes beyond the state of the art.The action will stimulate participation by a range of organizations and their networks in implementing the operational GMES services. It will require the development of innovatory approaches to the management of in-situ data, building on existing mechanisms, but exploring ways of managing them that have not in the past been necessary. Its impacts will be in terms of supporting GMES services, and providing a firm framework for future GMES in-situ management.The high-level objective of this project is to act between data providers and to develop an adequate management system for insitu data that also takes into account that demands will change over time. The outcome of this project is to have undertaken the preparatory work needed to develop a management system for in-situ data for GMES core services. The main results of the preparatory work are:1.Refocusing existing or establishing new networks of actors being able to supply the necessary in-situ information and adopt to changes in data requirements2.Clarifying and prioritizing requirements for data, the infrastructure necessary to provide it and related costs,3.Devising the framework necessary for deliver the required in-situ data, and4.Develop the Agency’s capacity to coordinate the in-situ component of GMES and undertake the role as defined in the Commission communication.To achieve thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Ultra-fast and Cost-effective Quantum Random Number Generator Photonic Integrated Chip'.

assistant: **Concept**

Random Number Generators (RNGs) generate random strings of bits that are used as keys in data encryption. These keys work with encryption algorithms and are crucial to ensuring data security. However, most commonly used RNGs do not generate truly random numbers, so encrypted data and communications are increasingly vulnerable to hackers. The most secure solution for ciphers is the use of Quantum Random Number Generators (QRNGs). These use quantum physics principles for true randomness.There are a number of barriers for QRNGs to be used in the market. Some existing QRNGs are too slow (i.e. only Mbps), some are not high-quality and all of them are too expensive. Also, QRNGs are 100mm2 or more, too large for many applications.Quside will overcome these barriers with a QRNG chip called Qupic. It uses standard components and manufacturing procedures. It is high-quality and lightning-fast (up to tens of Gbps). The Qupic chip is so small that it can fit inside of a smartphone and so fast that it satisfies the needs of a data centre. Our manufacturing processes allow us to build this technology not just faster and smaller than our competitors, but also orders of magnitude cheaper. The result will be a permanently secure infrastructure for data and communications.The QRNG market size will approach $1 billion by 2020. Apart from security in servers, the cloud and connected devices, QRNGs are also used for complex simulations in scientific, financial and engineering applications. Our initial target markets will be: data centre security, random numbers as a service, IoT devices, large-scale numerical simulations and smartphones/laptops/tablets.Quside is a technology start-up spun out from ICFO–The Institute of Photonic Sciences in 2017, developing quantum and photonic technologies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ChemArch: The organic chemistry and molecular biology of archaeological artefacts', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

We propose a European Joint Doctorate in response to the need for early stage training between the analytical sciences and archaeology. Archaeological chemistry, biomolecular archaeology and archaeometry are fast growing disciplines that have reinvigorated research of museum and archaeological artefacts. These approaches now offer forensic detail regarding the origin, manufacture and use of iconic and everyday items in the past. Articles published in the last year alone, such as the extraction of human genomes from Stone Age ‘chewing gum’, the fashioning of prehistoric hunting weapons from human remains, and the identification of milk in ancient ceramic infant feeding bottles, show how this field continues to influence a range of scholars, change curatorial practice and capture the attention of the global public. However, recruiting researchers with the necessary interdisciplinary skills to meet the rapid expansion of the field has been difficult.    To address this challenge ChemArch will: - Support the career development and training of 15 doctoral students crossing the sectoral divide between the natural and analytical sciences and social sciences.- Create a network of European specialist labs with complementary expertise and wordwide reach.- Link these specialised labs with non-academic research organisations, analytical instrument manufacturers, museums and field work units.- Provide coherent training around a thematic program converging on advancing our understanding of Europe’s rich prehistoric artefact record. - Involve leading organisations with a sustained history of delivering world-leading interdisciplinary science/humanities training at doctoral level.- Provide a durable legacy through the joint creation of guidelines for best practice in the field and the