RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Accelerating the iMpact of microsurgEry by upscaling production of thE world’s first microsurgical roboT: MUSA' (MEETMUSA) under Horizon Europe.

assistant: **Objectives**

The revolution in microsurgery is here. Microsure, a highly innovative Dutch medical device company is introducing MUSA, the worlds first clinically available CE-certified microsurgical robot.  We will maximize microsurgical performance by offering superhuman precision and comfort through robotic assistance in pursuit of excellence for both patients and health providers. The MUSA robot is highly efficient thereby reducing costs and improving access to microsurgical procedures. With the great unmet need in microsurgery, we are convinced that the timing for market introduction of MUSA is right and the field is ready to accept and implement MUSA for better patient outcomes. In this project, we will tackle the remaining bottlenecks for succesful outroll of the product including upscaling and optimizing manufacturability, to allow for rapid market uptake of MUSA after the project. MicroSure will introduce MUSA in all parts of Europe before 2029, reaching major societal and economic impact.


**Keywords:** Microsurgery,Microsurgical robot,Anastomosis,Open surgery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Revolutionising the diagnosis of multiple Sclerosis with the first bioinformatic diagnostic kit that allows early detection with a simple blood test' (2021-2027).

assistant: **Innovation**

Multiple Sclerosis affects around 700,000 people in Europe and 2.8 million worldwide. It is the most common chronic neurological disease in young adults in developed countries, and the main cause of disability after traffic accidents.Current diagnosis process takes one year (on average) which makes pharmacological treatment start late producing irreversible damage in patients and a worse prognosis. Combined with the high rate of misdiagnoses (20%), it leads to a healthcare cost of around €20 billion every year.ALA DIAGNOSTICS is revolutionising MS diagnosis with the first MS diagnostic kit, based on our patented recombinant protein, which is the only specific and clinically validated biomarker that exists for the diagnosis of MS in blood. Our diagnostic test is fast, easy, cheap, non-invasive, suitable for early diagnosis of MS and easy to integrate into daily clinical routine.


**Keywords:** Multiple Sclerosis,Diagnosis,Bioinformatics,Artificial Intelligence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Advanced solar facades with integrated collectors-accumulators for domestic hot water and space heating applications (ASFIC)'.

assistant: **Innovation**

Objectives and Problems to be solved: The main objective of the project is the development of a new type of solar facade, to be used in conventional urban, singular and refurbished buildings (with conventional or ventilated glazed facades). It will enhance the passive thermal behaviour of the building, increasing its thermal inertia and reducing its U-value, and also will allow the active collection and accumulation of significant quantities of solar thermal energy. The energy collected will be used for the conventional hot water and heating systems of the building. To reduce the cost, collectors and accumulators will be integrated in a single device, that will be prefabricated and then assembled in the facade. The design, that should satisfy technological, esthetical and economic criteria to be successful, will be optimised for three different European climates. To do so, advanced materials such as transparent insulation will be used. Description of the work: A consortium of companies (composed by architecture, engineering and construction companies plus an RTD performer, specialist in solar energy engineering) will be formed. The architectonic, engineering and economic demands needed to satisfy the objectives previously outlined will be analysed. Using the previous experience of the consortium, a set of preliminary designs will be developed. These preliminary designs will be optimised using two methodologies:· Numerical simulation using:1. CFD codes for the detailed determination of temperatures and heat flows in different zones of the facades.2. An architecture code to simulate the behaviour of the buildings with the facades to be developed.· Experimental work using:1. The state of the art heat transfer and fluid dynamics experimental techniques (such as particle ima
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Users specification of the complete ertms (European rail traffic management system)' to be submitted under Fourth Framework.

assistant: **Abstract**

The project addresses the full range of preparations activities leading to full scale trial tests of the European Rail Traffic Management System (ERTMS) in a number of pilot sites to be located in France, Germany and Italy. The project activities are to be split into two main phases as follows:Phase 1 : 1. Completion of the users requirements specifications of the ERTMS-ETCS kernel , including functional, system and subsystem requirements and overall safety concept.2. Specification of system functional, performance and interoperability tests.3. Customization of the systems for the foreseen trial sites (on-board and track-side components)4. Preparation of the file of common technical specifications for the call for tenders regarding the pilot installations for the trial sites.Phase 2 : Demonstration of the feasibility of the different ERTMS environment components - common kernel and specific and national modules and interfaces - through functional modelling of the system based on software and/or hardware simulation approaches. %To enable compliance with the interoperability objections for the trans-European rail network (Dir 91-440 and STI)Demonstration sites on SNCF, DB and FS" networks %ERTMS - EUROSIG / MORANE / EMSET"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Non-Traded Assets in Over-the-Counter Markets' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Many financial assets trade in decentralized over-the-counter (OTC) markets, that is, there is no centralized marketplace and investors need to search for counterparties that are willing to trade. Contrary to centralized markets, in OTC markets a substantial share of available assets is non-traded. Existing OTC market research focuses on frequently traded assets but is unable to talk about non-traded assets (NTA). But, why do many assets in OTC markets not trade in the first place? Which frictions give rise to NTA? These questions are highly relevant for policy makers and financial stability as well because OTC markets play a central role in the financial system. This proposal presents three empirical projects that will advance our understanding of the role of intermediation frictions in OTC markets through a novel perspective—the lens of NTA.Exploiting unique data for one of the largest OTC markets (U.S. corporate bonds), the research agenda comprises the following components:1) Search Frictions and Non-Traded Assets. This part examines the role of search frictions for NTA. Ex-ante it is not obvious whether a large share of NTA is symptomatic of low or high search frictions. The idea is to exploit different types of shocks that affect investors’ search frictions and to investigate their impact on NTA.2) Financial Intermediaries and Non-Traded Assets. This part studies whether financial intermediaries matter for NTA. Do assets trade more likely when intermediaries are financially unconstrained? To answer this question, the idea is to exploit detailed data on trading links between investors and dealers.3) Corporate Finance and Non-Traded Assets. This part examines whether firms derive financial flexibility from NTA. If assets do not trade, then their investor base remain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Advanced spatial phase shifting techniques and applications to non-destructive testing of large engineering components on-site' (PhaseMaster), addressing dissemination and exploitation.

assistant: **Impact**

With the rapid expansion in wind energy sector world wide, there is an increasing need to develop a technique that can be used to inspect wind turbine blades (WTB) on-site, so that the reliability and integrity of the structure and components can be maintained. However, most of the existing NDT techniques are difficult to use for WTB inspection on-site because of the complex working conditions and restrictions. Shearography technique has shown great potential in this aspect, and has been used in laboratory within a huge vacuum chamber to inspect large components. This proposal aims to develop advanced optical NDT techniques that can be used to inspect WTB and other large engineering components/structures on-site.The main objectives are:• Develop an advanced spatially phase shifted digital shearography (SPS-DS)• Develop robust algorithms to extract phase from single specklegram and from multiple specklegrams• Extend the working range of the system by rigid body motion compensation• Demonstrate the prototype system for wind turbine blade inspection on-siteThe host organisation, TWI, has been working closely with industrial partners across Europe to develop new NDT techniques for two decades. Projects have successfully involved the whole supply chain including SMEs, RTDs and LE end users. TWI’s 3500 membership base will ensure that the fellow will be exposed to a wide range of potential contributors and end users. This project will benefit end-users across a range of industries by developing novel optical techniques, improving reliability and integrity of engineering components.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Bio Knowledge Agora: Developing the Science Service for European Research and Biodiversity Policymaking'.

assistant: **Objectives**

Despite improved understanding of the need for science to inform biodiversity related policy making and the rich field of science-policy interfaces (SPIs) there remains a gap in ensuring that all decision makers across all societal sectors have direct access to research-based knowledge when planning, budgeting and deciding on actions that have an impact on local, national, EU and global biodiversity. BioAgora will develop a Science Service for Biodiversity (hereafter referred to as Science Service), which responds to the present gaps and future needs in SPIs and provides the science pillar of the EU’s Knowledge Centre for Biodiversity (KCBD). It will channel the entire landscape of EU biodiversity science from monitoring to meta-analyses and communicate this knowledge through two-way platforms to EU institutions and the broader community. To do this, the project will use ongoing processes of SPIs across Europe and beyond, as knowledge exchange networks, to address the most urgent needs identified for the Science Service. BioAgora will go beyond the state of the art by co-creating new ways of bridging the gap between science, practice and policy and use this as a basis for the Science Service’s development for future needs. To do this, it will 1) analyse the existing landscape of SPIs, assess their policy tools and the current biodiversity knowledge held in Europe, 2) engage with a broad range of actors –those already established ones and those not yet fully integrated within the landscape, as well as the users of SPIs; 3) form the Science Service governance structure and systems model along the projects span by testing it in real life; 4) provide capacity building for the EU community of decision makers to become empowered for transformative change for biodiversity. Bio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'LNP-DECODE: Broadening the therapeutic window of LNP-based vaccination' (LNP-DECODE) targeting Horizon Europe.

assistant: **Abstract**

The recent success of ionizable lipid nanoparticles (iLNPs) as vehicles for mRNA (mRNA-iLNP) as a safe and highly effective vaccine in the protection against SARS-CoV-2 pushed the lipid nanoparticle technology to the forefront of medicine and launched worldwide interest in their potential as a therapeutic vaccine against numerous pathogens or tumor antigens. Still, their mode of action remains largely a black box. One of the most remarkable properties of mRNA-LNPs is that they do not require any additional adjuvant, explaining for a large part their success. Current belief poses that their adjuvant activity originates from the ionizable lipids without any need for mRNA components. Our data challenge this belief as we found that empty, non-mRNA containing LNPs induce homeostatic, not immunogenic dendritic cell (DC) maturation. This observation has far-stretching clinical implications as it suggests that if one finds a reliable manner to incorporate antigens in a non-immunogenic fashion in LNPs, i.e. as peptides or non-immunogenic mRNA molecules, we can broaden the scope of LNPs from inducers of protective immunity to inducers of tolerance. The current project aims to explore this idea by testing the induction of tolerance against allergens and auto-immune antigens incorporated as peptide cargo within LNPs. In addition, we developed a unique toolbox with a set of biomarkers that distinguish tolerogenic from immunogenic mature DCs.  In the current project, we want to validate whether we can use these biomarkers to monitor in vivo the effect of different types of LNPs on DCs and predict their capability to induce tolerance or immunity. We believe that these findings will be highly valuable to help rational design of the future generation of LNPs, guarantee a safer use in th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ancient Religious Dedications in the Western Mediterranean Basin' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Ancient European cultural features are made up of epichoric creations, transfers and even local adaptations. Before Roman domination led to a new, centralised kind of cultural context, numerous peoples had developed their own cultural and identity codes through creation, adaptation and re-elaboration of concepts and objects. The goal of this project is to identify these processes of creation in Pre-Roman peoples' written expression. An innovative criterion has been chosen to accomplish this challenge, that is, the epigraphical genre (EG), whose definition through its material and textual elements (ME and TE) we have developed, and we will refine through this project. A particular kind of EG,  the religious dedication (RD),  is our starting point due to their wide diffusion and their significance in identity matters. We believe that the epigraphical approach is idoneous to achieve this aim, given its holistic results and its multidisciplinar methodology. It also involves a direct analysis of the pieces, which contributes preserving European archaeological, linguistic and religious heritage. All the results will be stored in an updated, accesible online epigraphical DataBase of all the Pre-Roman and early Roman RD in the Roman West, which will facilitate knowledge transfer at all levels and on which our further research will be based.The proposed interdisciplinary research combines the linguistic and socio-linguistic approach, led by Dr. Emmanuel Dupraz (the supervisor), with the historical/epigraphical perspective, provided by Dr. María José Estarán (the ER) at the Université Libre de Bruxelles (ULB).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Single-Molecule And Structural Studies Of ATP-Dependent Chromatin Remodelling' in the context of a Horizon 2020 call.

assistant: **Objectives**

The packaging of genetic information into chromatin regulates a wide range of vital processes that depend on direct access to the DNA template. Many chromatin-interacting complexes impact chromatin structure and their aberrant regulation or dysfunction has been implicated in various cancers and severe developmental disorders. A better understanding of the roles of chromatin-interacting complexes in such disease states requires a detailed mechanistic study. Many chromatin-interacting complexes modify chromatin structure, yet understanding the underlying mechanisms remains a major challenge in the field. Furthermore, how chromatin-interacting complexes are regulated to enable their various functions is incompletely understood. We will address these longstanding questions in two specific aims. Aim I: Building on our expertise in single-molecule biology, we will develop powerful single-molecule imaging approaches to monitor the action of chromatin-interacting complexes in real time. We will further probe how the diverse activities of the chromatin-associated complexes are coordinated and coupled to conformational transitions. Aim II:  Drawing on our expertise in structural biology, we will use a range of structural techniques in combination with biochemical approaches to study the vital regulation of chromatin-interacting complexes by their regulatory subunits as well as by chromatin features. We expect to obtain ground-breaking insights into the mechanisms and regulation of disease-related chromatin-associated complexes, which may open up new horizons for developing therapeutic intervention strategies. Furthermore, the approaches developed here will enable the investigation of a large number of chromatin-related processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Platform Universal Self Hosting, a hybrid-cloud Platform as a Service reducing web application development cost by 40% for SMEs' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The PLUSH project is meant to create a next generation PaaS (Platform as a Service) – that can run multiple applications in multiple computing languages using multiple data backends on a Hybrid-Cloud infrastructure. PLUSH will be the first self-hosted PaaS (able to deploy itself on any private or public cloud) which thus will generate different deployment modes for client applications (public cloud, private cloud, as a hybrid-cloud, on multiple clouds). PLUSH will be a distributed and decentralized system powered by a high-availability grid of micro-services.There has been a recent strong trend to unify software development and operations in order to reduce release cycle times and gain in quality and velocity. Following this trend, PLUSH project addresses the web development market on these two converging segments, the web application development tools market and the web application hosting market. Within the two year period of the project, three pilots will be respectively conducted respectively within a web agency, a high-growth SaaS SME and a public sector entity to validate the PLUSH platform and the productivity gains on the key targeted markets.With PLUSH, Commerce Guys an open source start-up, will maintain its current technological advance thanks to the evolution of its existing PaaS “platform.sh”, that has already been deployed by 200+ clients since its launch, 5 months ago. This advance stems from its mature container based micro-services architecture, technology which has been recently adopted by leaders such as Amazon, Google and Microsoft. Commerce Guys business ambition is to reach 5% of the PaaS market segment in Europe and in the US within the next 5 years, with a 9M€ revenue milestone for the full year of 2017.  Our business plan relies on three sales c