RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'GoNaturePositive!' (GoNaturePositive), addressing dissemination and exploitation.

assistant: **Impact**

The world’s economic systems do not currently recognise the value of nature to planetary and human health, and mainstream economic drivers negatively affect the natural world both directly and indirectly. The degradation of land and marine ecosystems undermines the well-being of billions of people, costing about 10% of the annual global gross product. However, the restoration of nature presents enormous economic opportunities. The idea of a Nature-Positive Economy (NPE) – an economy that fully considers environmental impacts and sustainability, and works to actively improve the state of nature – and the pathways towards realising it remain poorly understood.The ambition of GoNaturePositive! (GoNP) is to provide much-needed clarity and direction through a transdisciplinary consortium adopting a multi-stakeholder approach for systemic change, with nature-based solutions (NBS) and nature-based enterprises (NBEs) at its core. Five European and one Global Pilot (covering Agri-Food, Forestry, Blue Economy, Tourism & the Built Environment) will be co-created with industrial, political, NGO and societal stakeholders. In GoNP we will deliver a clear definition and conceptual framework for the NPE, a roadmap proposing policy and governance pathways towards a NPE, blueprints for ground-breaking solutions to stubborn roadblocks, and demonstrations of what a NPE could look like on the ground.GoNP will demonstrate how nature-positive practices can generate multiple benefits for people and planet while reducing business risk and attracting increasingly nature-sensitive investors. It will pay particular attention to the role and potential of NBEs, developing unique platforms and capacity building measures to help them scale for maximum nature-positive impact. Finally, we will cultivate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Targeting OBesity-driven Inflammation'.

assistant: **Concept**

The TOBI project aims to analyse mechanisms provoking adipokine-mediated crosstalk and an inflammatory drift in obese patients. It will be the remit of this project to develop novel strategies to reduce or reverse major adipokine-mediated adverse interactions in peripheral tissues and by periorganic adipose tissue, namely insulin resistance and vascular dysfunction, respectively. Special attention will be given to the study of novel lipid-derived adipokines and the identification of targets for drug development that could interfere with the obesity-associated inflammatory drift. TOBI research focuses on molecular mechanisms initiating and promoting inflammatory signalling pathways in adipocytes and adipose tissue macrophages that cause a shift to inflammatory adipokines to interfere with insulin sensitivity and vascular function. Adipocyte dysfunction by alterations in ER stress signalling and lipolysis will be analysed as probable starting points of adipocyte inflammatory alterations. Signalling pathways and transcription factors controlling expression of inflammatory adipokines and anti-inflammatory adipokines will be studied. TOBI will particularly investigate lipid-derived adipokines that have been little studied to date. Key molecules of pathophysiological relevance will be validated for their potential as targets for drug development. The TOBI consortium will mount a comprehensive collaborative program for analysing the molecular mechanisms underlying regulation of adipokine production and their function in target tissues using genetic, molecular and biochemical approaches. The consortium combines all necessary expertise to investigate the basis of the obesity-associated inflammatory drift. A TOBI toolbox will be developed that strengthen collaboration and compara
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'PROtein SEQuencing using Optical single molecule real-time detection'.

assistant: **Innovation**

The advent of analytical techniques with extremely low limits of detection has led to dramatic progresses mostly in the field of nucleic acids sequencing. Despite the advent of the next generation sequencing platforms, the current genome sequencing task remains formidable, and revolutionary advances in DNA sequencing technology are still demanded. Nevertheless, the primary actors in virtually all life processes are the proteins coded by DNA sequences known as genes. Proteins can yield far more compelling revelations than may be gleaned from DNA alone. Protein sequencing may radically transform patient treatment, enabling precise monitoring of disease response to therapeutics at the molecular level. Single-molecule sequencing of proteins is of enormous value, offering the potential to detect diminishingly small quantities of proteins that may have been altered by alternative splicing or post-translational modification. In this project, we build upon current state-of-the-art sequencing technologies to develop novel proof-of-principle technologies for high-throughput protein sequencing and  single molecule DNA/RNA sequencing. The work proposed herein will provide: (i) a new sequencing technology development that utilizes plasmonic nanostructures in order to enhance the optical detection and to control the molecules movement by means of optical trapping; (ii)  a novel approach of plasmonic based optical spectroscopy for sequencing of protein; (iii), a rigorous analytical model to reconstruct the exact sequence from the signals recorded; and (iv) a plasmonic device that can perform both nucleic acids and amino-acids sequencing in one functional unit. These research efforts provide a foundation for the novel use of systems for a wide range of applications, such as the framewo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'EU-CHINA-BRIDGE - Building Roadmaps to Industrial Decarbonisation and Green Economy through EU-China Cooperation' (EU-CHINA-BRIDGE), addressing dissemination and exploitation.

assistant: **Impact**

EU-CHINA BRIDGE will support the transition to a climate-neutral and resilient society in both Europe and China by jointly advancing knowledge on technology innovations and roadmaps for decarbonising energy intensive industries, co-creating innovative modelling by combining cutting-edge bottom-up and integrated assessment modelling to quantify net-zero sustainable pathways, and developing the most updated and comprehensive emissions data. It will intensively engage relevant stakeholders from both regions, enhancing dialogues, and fostering mutual learning among policymakers, industries, and experts. It will deliver two open-source EU-China joint technology inventories of promising net-zero emission technology options for the iron & steel and chemical industries, two co-implemented demonstrations of promising technologies in China, and co-created scale-up paths and roadmaps of the selected industrial technologies in both regions. It will also develop the most up-to-date, high-resolution, multi-sectoral, national and regional GHG and short-lived climate pollutant emission inventories as well as dynamic monitoring of key emission sources at high spatiotemporal granularity. A state-of-the-art modelling framework will be developed, exploiting and advancing cutting-edge and established modelling tools for EU and China, using the latest emissions data, representing technology and policy options, enabling assessment of socioeconomic impacts, covering multiple economic sectors and regions, and offering high spatial and technology detail. The enhanced models will be used to co-produce net-zero pathways for the EU and China, explicitly assessing co-benefits and trade-offs of climate policies with other societal goals while exploring cooperation policies and governance to drive the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'New environmentally-sound methods for pitch control in different paper pulp manufacturing processes'.

assistant: **Objectives**

The accumulation of wood extractives in paper mills (forming the so-called pitch deposits) result in low-quality pulp and blockages causing important economic losses as well as effluent toxicity. This proposal focuses on the pilot-scale development of environmentally-sound methods for pitch control during manufacture of selected pulps (spruce TMP and eucalypt TCF-bleached Kraft pulp) based on:I) fungal strains selectively-removing compounds responsible for pitch deposition to be used for formulation of inoculate to treat wood;ii) to use of new industrial enzymes (native or engineered proteins) for removing pitch compounds and optimised protocols for expression, fermentation and purification of these enzymes,iii) suitable combination of the above treatments with improved physicochemical methods to remove pitch or decrease its disposability;iv) analysis of advantages of the new processes in terms of control of pitch deposition, pulp and process parameters, and effluent treatment and toxicity; andv) evaluation of the commercial interest of the of the(suite dossier)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Documentation of lung growth after tracheal occlusion to reverse pulmonary hypoplasia in congenital diaphragmatic hernia. Experimental studies in the rat and clinical implications of fetal therapy'.

assistant: **Concept**

The objective of the “Fetalproject2010” is to advance our knowledge in fetal medicine. We focus on pulmonary hypoplasia (PH) in congenital diaphragmatic hernia (CDH) and its relatively new prenatal treatment option, tracheal occlusion (TO). TO prevents egress of pulmonary fluid, thus triggering lung growth. Yet, the procedure is invasive, with main risks premature rupture of membranes and preterm delivery. The question remains as to the optimal occlusion period. We aim to investigate the effects of TO at distinct phases of lung development in the nitrofen (NF) rat. Our results will provide a scientific basis for timing of TO in human CDH fetuses. Patients after fetal surgery are at high risk for tocolysis. One drug frequently used is nifedipine, which inhibits airway small muscle (ASM) contractions in vitro. ASM are believed to be crucial for lung development. We plan to study the impact of nifedipine application on hypoplastic lungs ±TO in the NF rat. Our results will demonstrate potential safety issues. Few centers, including the two host institutions, offer fetal surgery such as TO. We aim to investigate with questionnaires how couples are affected psychologically by interventions. Our results will help to identify the distinct needs of these parents and to tailor support. MRI-spectroscopy (MRS) and fetal magnetoencephalography (fMEG) offer new non-invasive methods to study fetal fluid composition, organ function and development. CDH is associated with altered levels of e. g. vitamin A and decreased cerebral perfusion, the functional impact of the latter is unknown. We aim to investigate the potential of MRS and fMEG in studying lung development as well as brain activity in fetuses with CDH. These results will help to define new markers and methods for diagnostic and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Reaching out: Science for All - Science meets Citizens' to be submitted under Seventh Framework.

assistant: **Abstract**

As the City of Trier is the economic and cultural centre of the greater region, the first Researchers’ Night in Trier will take place in the City with good infrastructural connections to the neighbouring countries of Luxembourg, Belgium and France. In the Researchers´ Night, science “meets” the city of Trier and their institutions in 9 different fields: (1) culture, (2) Design, (3) Crime, (4) Economy (especially with regard to local and regional needs), (5) History, (6) Technology, (7) Ecology, (8) Health and (9) Europe. In the focus of all activities is the general public. There will be science for young and old, regardless of their scientific background. A variety of different activity types will be made available to the public: interactive, accessible and accompanied hands-on experiments, shows and demonstrations, bridges to other domains like art, literature and music, visits to unusual places and guided tours, exhibitions, “touch science” experiments, lectures presentations with common interest subjects, science cafés, presentation of researchers’ hobbies (e.g. Profs on Air), challenges with researchers, Science Slam, Childrens’ University etc. Activities during the researchers’ night will take place at various venues all over the city like museums, schools and different public squares outside. To maximize the benefit the “tracking” will allow the attendance of different events at different times. Even the time you need from A to B may be filled by special academic offers, e.g. a lecture in a public bus or an academic walk through the city. Circuits will help undecided visitors and ensure balanced participation in activities. For this reason coping with plenty should be easy to manage for all visitors. The aims of the Researchers’ night in Trier consists of continu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Na-Ion bAttery Demonstration for Electric Storage' under Horizon 2020.

assistant: **Concept**

Wide scale implementation of renewable energy will require growth in production of inexpensive, efficient energy storage systems. The extension of battery technology to large-scale storage will become necessary as intermittent renewable energy sources such as wind, solar and wave become more prevalent and integrated into electrical grid. Lithium-ion battery appears as quite mature for this application but its cost per mWh remains high in comparison to high temperature technology such as Zebra, which integrate low cost sodium base materials. Furthermore, as the use of large format lithium battery becomes widespread; increase demand for lithium commodity chemicals combined with geographically constrained Li mineral reserves will drive up prices. Based on the wide availability and low cost of sodium, ambient temperature sodium-based batteries have the potential for meeting large scale grid energy storage needs. In NAIADES we will demonstrate the feasibility of ambient temperature Na-ion battery from the knowledge and achievement that has been done at the laboratory scale, up to a module demonstration in a realistic application environment.  Several European industrials, institutes and universities belonging to ALISTORE-ERI have decided to join their efforts to assess the Na-ion technology for stationary storage application through building a 1 kW modules system Na-ion cell which will serve as data base to demonstrate economical and public acceptance.These module prototypes will be developed to meet performances in a 1kW system in a cost-effective, sustainable and environmental-friendly manner. New energy policy will be developed to integer the Na-ion battery in the Smart Grid initiative and promote the penetration of renewable energy in the electric network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unravelling early dinosaur success through fossil digestive contents and trophic dynamics' under Horizon Europe.

assistant: **Concept**

The early radiation of dinosaurs, spanning approximately 30 million years from their emergence to dominance of terrestrial ecosystems, remains a complex and poorly understood evolutionary event. While previous studies have focused mainly on phylogenetic aspects, less attention has been given to the ecological dynamics that drove their success. This project aims to fill that gap by employing a novel, multidisciplinary approach to investigate the early evolution of dinosaurs through the lens of their dietary and trophic interactions. By analysing bromalites (fossil digestive remains) using cutting-edge methods like synchrotron microtomography, I will infer the food webs in which early dinosaurs participated, shedding light on how their diets and ecological roles evolved. Comparative analysis across Pangean regions and different time periods will enable the construction of a comprehensive palaeoecological model, highlighting key factors in their rise to dominance. Furthermore, I will apply biomolecular techniques adapted from archaeological geochemistry to identify preserved organics within these fossils, providing unprecedented insights into predator-prey relationships. These findings will be integrated into a holistic eco-evolutionary model, offering new perspectives on dinosaur success with broader implications for understanding mass extinction dynamics and current biodiversity crises. To achieve this, I will collaborate with leading experts and engage a team of PhD students and postdocs, ensuring the project’s multidisciplinary goals are met.


**Keywords:** Coprolites, food webs, early dinosaurs, mass extinction, Triassic-Jurassic transition, synchrotron microtomography
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Brain endothelial cell-based gene therapy of neurodegenerative diseases' to be submitted under Fourth Framework.

assistant: **Abstract**

Neurodegenerative diseases, like Alzheimer's, Parkinson's or Huntington's diseases, constitute a major health problem in Europe. There are no therapies for these diseases except in the case of Parkinson's disease where current pharmcological treatment can limit for a time the evolution of the symptoms. However, some neurotrophic factors have been identified as drug candidates. Neurotech's core technology is based on the use of brain endothelial cell lines as cellular vectors for drug delivery to the CNS. Accordingly, the present programme is focused on the production of gentically engineered brain endothelial cell lines secreting neurotrophic factors under the control of viral or housekeeping gene promotors identified by NeuroSearch. The therapeutic efficacy of these cell lines will be evaluated by cerebral transplantation in rats with experimentally induced neurodegenerative diseases. Among the criteria assessed will be the survival of susceptible neuronal populations and the improvement in animal behavior at various times after transplantation. As a therapeutic approach of neural transplantation in Parkinson's disease, the feasibility of grafting human fetal neurons is now clinically well established. However, this strategy, dependant on a constant supply of human fetal tissues, raises important ehtical and practical issues. Alternatively, the present programme, based on the use of stable cerebral endotherlial cell lines, could contribute to the further development of a novel therapeutic strategy for neurogenerative diseases.