RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Role of Local Protein Degradation in Neurotransmitter Release and Homeostatic Plasticity' (SynDegrade).

assistant: **Innovation**

While many neurons live for decades, the proteins that determine neural function have half-lives of hours to weeks. On the one hand, this allows for plastic changes during development and learning. On the other hand, this poses the question of how stable neural function can be achieved and maintained at all. Several neurological diseases, such as epilepsy or migraine, have been linked to uncontrolled neural function. However, the molecular mechanisms that stabilize nervous system function are poorly understood. The major site of regulation of neural activity is the chemical synapse. Synaptic function is tightly linked to the specific composition and abundance of proteins at synapses. However, the molecular pathways underlying the homeostatic control of protein levels at synapses, henceforth called synaptic proteostasis, are largely unknown.The main objective of this proposal is to unravel the molecular signaling systems underlying synaptic proteostasis through local protein degradation, and its role in regulating a key step in synaptic transmission: neurotransmitter release. We propose to systematically analyze Ubiquitin Proteasome System (UPS)-dependent modulation of synaptic transmission in mutants of all major classes of synaptic genes, with a focus on homeostatic plasticity genes. This will be realized by employing a unique combination of forward genetics and electrophysiological analysis of synaptic transmission in Drosophila. Novel genetically-encoded probes will be used and developed to study synaptic transmission and protein degradation, and to acutely perturb protein function. Finally, this new information will be translated into the mammalian CNS by studying UPS-dependent modulation of release at a CNS synapse that allows for a detailed biophysical description
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'SEROLOGICAL TESTING AND TREATMENT FOR P. VIVAX: FROM A CLUSTER-RANDOMISED TRIAL IN ETHIOPIA AND MADAGASCAR TO A MOBILE-TECHNOLOGY SUPPORTED INTERVENTION'.

assistant: **Innovation**

P. vivax is considered the most difficult human malaria to eliminate because of the inability of conventional diagnostics to detect individuals with latent liver forms. These individuals account for 80% of all infections and can readily infect mosquitoes. Currently countries can test knowing this has little impact or and the treat everyone which exposes individuals to drugs with potentially dangerous side effects. Parasite specific antibody responses have been shown to correlate with the likelihood of hypnozoite carriage and can be used to identify individuals who should be treated.Aim is to implement a Cluster-Randomised Trial in Ethiopia and Madagascar to demonstrate the effectiveness of a new anti-malaria intervention based on Plasmodium vivax serological testing and treatment (PvSTATEM) with primaquine to prevent the relapse infections responsible for maintaining P. vivax transmission. Simultaneously, we will assess social and health system acceptability of such an approach as well as  refine  new mobile technologies which interface with point-of-care diagnostic tests and guide treatment decisions.We aim to reduce  malaria burden at both the individual and population level in two countries which experience the highest levels of P.vivax in Africa. We expect to have a significant effect in reducing morbidity and improving health. We will ensure community engagement and assess the adoption of new technologies that align with those existing in the health system. The proposal is built on equal partnership and shared  capacity to address a substantial public health burden.


**Keywords:** malaria, serology, P.vivax, Ethiopia, Madagascar, Primaquine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Assessing the Transport of Nanoplastics in Freshwater sources and their Detection via Nanosorption Approach'.

assistant: **Objectives**

Human exposure to plastics is increasingly recognized as a global environmental threat, primarily due to the invisible and persistent accumulation of its residual content in freshwater sources. While a wealth of studies was still focused on investigating the ecological concerns of microplastics, the highly transformative nature of plastics began to increase the concentrations of nano-sized plastic particles (< 1 µm)  in the environment. It is hypothesized that the recalcitrant nature of the nanoplastics facilitates their continuous migration from soil into river systems, leading to their introduction into the food cycle. Indeed, the estimates of nanoplastic leakage from soil to freshwater sources are still considered a missing link in the scientific community. Therefore, there is a high need to establish the mechanisms behind the fate and transport of nanoplastics in freshwater sources by identifying the major hotspots of its accumulation. The research project ""NanoplastSorption"", is based on the development of carbon-based nanomaterials (CNMs) using lignin as the primary carbon source and polytannic acid as a coating agent. The integration of polytannic acid as a hybridizing material with CNMs enhances their sorption efficiency for both cationic and anionic nanoplastic residues, thereby improving detection potential of CNMs. The study involved an initial assessment of the physicochemical properties and morphological characteristics of aged and unaged nanoplastic particles and subsequently their transport under diverse environmental, hydrological, and biogeochemical conditions. Further, the study utilized fluorescent surface-functionalized CNMs to detect and quantify both aged and unaged nanoplastics particles accumulated in distinct soil and water strata throughout t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel Processes and Equipment in Composite Repair Technology' (NEWCORT).

assistant: **Innovation**

NEWCORT will develop and validate novel processes and equipment for the repair of composite airframes. Three key stages in the bonded composite repair procedure were identified, namely material removal & surface preparation, heating for polymerization of patch and positive pressure application for improved compaction of patch layers. In all three stages novel processes will be developed, either through integration of innovations already existing within the proposing consortium or through research focused in targeted areas. For material removal, developments include process optimization to enable close tolerance applications for curved thick composite structures, potentially combined with scarfed pre-cured patches, potential simplification of stepping requirements and adaptation of material removal equipment to most frequent geometries (e.g. fuselage curvature). Novel heating processes and equipment will focus on the polymerization of new types of resins (e.g. M20 at 140oC), possibly including thermoplastic materials, through application of new power supply control logic, dielectric sensors for curing and viscosity monitoring, heating flux sensors for improved curing control, heating mats with embedded thermocouples and dielectric sensors, simulation software for selection of blankets and thermocouples installation topology, as well as development of Quick Composite Repair (QCR) kits for most frequent aircraft repair cases. Finally, the development of positive pressure application equipment for flat / curved structures will be studied, together with optimized pressure measurement devices and control software, mountable to most frequent repair cases (e.g. composite fuselage curvature). The application of such novel processes in real-life aeronautical environment will be g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cell Growth and Size Homeostasis in Proliferating Mammalian Cells' (CELLCYCLEGROWTHSIZE) targeting Seventh Framework.

assistant: **Abstract**

Cell size is central to cell function and ultimately to tissue architecture.  Size reflects a balance between cell growth - steadily increase of size, and cytokinesis which halves the cell’s size on each division. How cells attain and maintain their size is a fundamental question that has fascinated generations of biologists, but the answer remains obscure. For proliferating cells growing in unvarying conditions, cell size is basically time-invariant, suggesting that the growth cycle and the cell cycle are coupled. In yeast, an intrinsic size-sensing mechanism coordinates cell cycle with cell growth. Whether such a mechanism is restricted to single-celled organisms is a long-lasting debate. These problems pioneered by Mitchison, Nurse and Zetterberg, captivated the scientific community in the past. But the real challenge of monitoring growth of objects as minute as cells, left these questions neglected for decades.In order to meet the challenge, I have combined cell biology approaches with engineering and mathematics, and was able to overcome long-standing experimental limitations, and, for the first time, to accurately describe the growth (size over time) of a proliferating mammalian cell. These studies suggested that at least some mammalian cells must have an intrinsic size control mechanism that, like in yeast, coordinates cell size with cell division.  My work, performed in Marc Kirschner lab at Harvard, was published as a full article in Science.Here I propose to study the physiology and the molecular basis of size homeostasis in proliferating mammalian cells. Using advanced methodologies to monitor cell growth, cell cycle and cell size, and by applying cell and systems biology approaches to cell growth and cell cycle regulation, I aim to elucidate i) whether size-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Safety, Liquidity, and Crises', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Over the past 15 years, the euro area experienced two large financial crises (global financial; debt crisis), and two non-financial crises (Covid, war/energy) with spillovers to the financial system. Curiously, all these crises involved distress in markets for assets which were supposedly liquid and safe: for example, repos and MBS in 2008, and sovereign bonds in the 2010 euro-area and October 2022 UK crises. But even though liquidity and safety play a key role in theories and narrative accounts of crises, most empirical studies of crises focus on risk, creating a key gap in the literature.My proposal will fill this gap by conducting the first systematic study of the role market liquidity and safe assets play in financial crisis events. To do this, I will collect new long-run data on i). Quantities of safe and liquid assets (produced by financials and governments), and ii). Prices of liquidity and safety (measured by bid-ask and yield spreads), for 17 advanced economies during 1870–2020.I will use these data to better understand which assets are safe and liquid, and what role liquidity and safety play in the build-up and aftermath of systemic crisis events. To do this, I propose five projects to study1. How quantities of safe assets evolve over the long run, and around crises.2. How safety & liquidity vary across & within asset classes, and over time.3. How market liquidity relates to crisis risk and real activity.4. How liquidity and solvency stress transmit and interact at bank level during crises.5. How changes in quantities of safe and liquid assets affect their prices.The initial analysis will be empirical, done at macro level. It will be complemented by theory (project 1), and micro-level security/bank-level evidence (projects 2–4) to improve identification and un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Bimanual Manipulation of Rigid and Deformable Objects'.

assistant: **Concept**

All day long, our fingers touch, grasp and move objects in various media such as air, water, oil. We do this almost effortlessly - it feels like we do not spend time planning and reflecting over what our hands and fingers do or how the continuous integration of various sensory modalities such as vision, touch, proprioception, hearing help us to outperform any other biological system in the variety of the interaction tasks that we can execute. Largely overlooked, and perhaps most fascinating is the ease with which we perform these interactions resulting in a belief that these are also easy to accomplish in artificial systems such as robots. However, there are still no robots that can easily hand-wash dishes, button a shirt or peel a potato.  Our claim is that this is fundamentally a problem of appropriate representation or parameterization.   When interacting with objects, the robot needs to consider geometric, topological, and physical properties of objects. This can be done either explicitly, by modeling and representing these properties, or implicitly, by learning them from data. The main scientific objective of this project is to create new informative and compact representations of deformable objects that incorporate both analytical and learning-based approaches and encode geometric, topological, and physical information about the robot, the object, and the environment. We will do this in the context of challenging multimodal, bimanual object interaction tasks. The focus will be on physical interaction with deformable objects using multimodal feedback. To meet these objectives, we will use theoretical and computational methods together with rigorous experimental evaluation to model skilled sensorimotor behavior in bimanual robot systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Multiplex phOtonic sensor for pLasmonic-based Online detection of contaminants in milK'.

assistant: **Objectives**

The main objective of MOLOKO project is the manufacturing, implementation and validation of a self-managing and automatic miniaturized integrated photonic sensor to be used as process analytical instrumentation for fast-response on-site monitoring of interest analytes for security and quality within milk supply chain. These challenging objectives are achieved by integrating within the same device platform forefront technologies as organic photonics, nanoplasmonics, immunoassay diagnostics and microfluidics. Specifically, we aim at realizing multiplexing quantitative detection of up to 10 analytes among which food safety parameters, e.g. antibiotics (i.e. penicillin, ampicillin, cephalonium) and toxins (i.e. mycotoxins and bacterial toxins) and food quality parameters e.g. lactoferrin and caseins by implementing a highly-integrated optoplasmonic-microfluidic  sensor in the strategic checkpoints along the entire supply and value chain of milk. The MOLOKO miniaturized integrated photonic sensor is specifically designed according to milk primary production, processing and distribution end-users in order to enable and guarantee fast, low-cost, robust, quantitative and high-sensitive multiplexing detection for the rapid acceptance screening of milk from primary producers (farm tank milk) or single bovine. The inherent versatility of the sensor guarantees disruptive effectiveness in multiple real settings applications, i.e. as automated sensor integrated in milking machine as handheld reusable analytical instrument for specialized and non-specialised milk operators.The effectiveness and market-placement of the engineered functional prototype is quantitatively evaluated by direct comparison with respect to standard analytical methods and commercially available optical biosensor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development and application of an individual-trait-based- simulator of Amazon forest dynamics'.

assistant: **Innovation**

We propose to develop an individual-based simulator for Amazon forest dynamics, which will be highly constraint with existing field data covering the whole basin for the last twenty years. Findings from the RAINFOR forest plot network include an East-West gradient in turnover times across the basin and an above-ground biomass trend. The latter finding has important consequences for the global carbon budget and thus greenhouse gas forcing. Specifically based on the plant functional traits section of the database, we will use the observed trait distribution to generate continua which will define the economy of the primary resources available for growth, and control the performance and fitness of each individual. The floristic composition and dynamics part of the database will be used to parameterise and validate the performance of the model, across different soil and climate gradients. The simulator will subsequently be used to explore existing hypotheses regarding the mechanism driving the spatial and temporal variation of the Amazon rainforest. Ultimately besides hypothesis testing we will also use the simulator to explore sensitivity of the system to a changing climate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'STate of the ARt Financial Services for the inHabitants of isolated areas' (STARFISH), addressing dissemination and exploitation.

assistant: **Impact**

Isolated areas are defined as regions characterised by intense isolation problems and small" population that function as the main obstacle to the provision of crucial public services through traditional means. The proposed project focuses on examining alternative ways to combat the isolation of these areas in the financial sector. Its objective is to identify and apply innovative solutions in order to provide financial services that correspond to the needs and the demands of people living in isolated areas around Europe, as well as their SMEs.These solutions will be based on the idea of the virtual bank branch consisting of business structures and technological solutions in order to extent the bank presence to these remote areas. This dynamic virtual entity will extend the bank presence and will provide financial services to remote areas using state of the art information and communication technologies.Work description:The project will identify, design, develop, apply and evaluate business models and technological solutions for the implementation of the virtual bank branch. The technologies for the implementation of the dynamic virtual entity will be based on the cash-augment model that allows the circulation of cash in remote areas and on the cashless society model that attempts to substitute cash by electronic value. Both technologies will be supported by a virtual help-desk system.The first step for the implementation of the virtual bank branch is to identify user needs. Based on national needs of two European countries with significant socio-economic differences, Greece and Finland, the project will result in a common place of needs related to financial services for the European citizen (individual and SMEs) of isolated areas. User needs will be the basis for the de