RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Perceptions of threat to personal values shape punishment judgments through social identity threat' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In modern societies, the criminal justice system is entrusted to punish norm violators in a fair and impartial way. Yet, punishment judgments are subject to biases, and are sometimes shaped by extralegal factors, as illustrated for example by the over-representation of African-Americans in inmates in the US. This project investigates one such factor, namely perceived threats to one’s personal values. We argue that even when unrelated to the wrongdoing, value-violations represent a threat to one’s personal values and to one’s identity. As such, value-violations trigger a motivation to restore the threatened values and identity, leading to differential punishment judgments as a function of the target’s fit or misfit with the perceiver’s values. We test this crucial role of perceptions of threat to personal values in two lines of research, using a combination of traditional experimental research methods, and modern measurement methods. In the line of research A, we aim to identify moderators of the effect of personal value on punishment judgments. Experimentally increasing or removing threat to values will allow us to gain a clearer understanding of the causal processes at play. In the line of research B, we aim to identify the neural processes underlying the effects of perceptions of threat to personal values on punishment judgments. Using fMRI, lesion patients and cardiovascular indices, we will gain complementary perspectives on the dynamics at play. As a result, the present proposal will enhance knowledge in the fields of values, social justice and morality, but also offer applicable strategies to reduce the impact of threat to values on real-life potentially consequential judgments, for example in the legal system.


**Keywords:** social psychology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Novel Oligonucleotide-based Strategies for Efficient Telomerase Inhibition'.

assistant: **Concept**

Within the last years, the ribonucleoprotein telomerase has emerged as an attractive, yet elusive, drug target for the treatment of cancer and several age-related diseases. This is because it has been estimated that telomerase is abnormally up-regulated in around 90% of human tumors. However, despite the current efforts to exploit the therapeutic potential of telomerase, there is still a need for the development of alternative chemical strategies that may unravel novel options for efficient therapeutic intervention, especially at a time when our understanding of many aspects of telomerase biology is ever increasing. The proposed research aims at the use of new molecular strategies for the discovery of efficient telomerase inhibitors based on oligonucleotide conjugates. The project will be based on an interfaced, multidisciplinary approach characteristic of the field of Chemical Biology. It will entail a combination of different techniques, including organic synthesis, coordination and nucleoside chemistry, spectroscopy, biochemistry, and molecular and cellular biology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'White Dwarfs as Tracers of Stellar, Binary and Planetary Evolution'.

assistant: **Innovation**

The vast majority of all stars in the Galaxy will evolve, or already have evolved, into white dwarfs, Earth-sized stellar embers sustained by electron degeneracy, and the study of white dwarfs is essential to many aspects of our understanding regarding the evolution of single and binary stars and of planetary systems. However, because of their intrinsic faintness, the known population of galactic white dwarfs is extremely fragmentary, in fact, we do not even have a complete census of white dwarfs within the nearest 20pc. The aim of this project is to produce the first deep, homogeneous all-sky sample of single and binary white dwarfs. I will achieve this ambitious goal by using the combined wealth of information that ongoing deep surveys, spanning the ultraviolet to mid-infrared, collect for about a billion objects in our Galaxy. My analysis and follow-up study of this new sample will advance our understanding of all aspects of the evolution of white dwarfs by at least an order of magnitude, and will produce answers to a wide range of fundamental questions:* How do white dwarf binaries evolve?* What is the population of Type Ia supernova progenitors?* How many white dwarfs bear the remnants of planetary systems?* What is the chemical composition of extra-solar minor planets?* What is the star formation history of the Galaxy?* How much mass do stars lose during their post-main sequence evolution?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Collaborating Smart Solar-powered Micro-grids' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

When considering renewable energy sources, like solar electricity, people often do not directly see the benefit of their investment. While the sun is shining and might be producing electricity in their homes, they are at their work and cannot use that energy directly, while when they need the energy at night (for laundry, lighting, computers) the solar panel is no longer producing. Indeed, research has shown that while in theory houses can be self-reliant on solar panels by the amount of electricity they produce, it would require considerable (and expensive) storage capacity to realize this.<br/>With smart management and control systems, different types of buildings (for instance a mix of houses, companies and schools) could be connected in such a way that this neighbourhood would use more, or even most, of its renewable energy within the community. For example, if one neighbour does not use her electric car one day, its battery can be used to store excess energy produced from the solar panels on another neighbour's roof.<br/>The CoSSMic project aims to develop the ICT tools needed to facilitate this sharing of renewable energy within a neighbourhood, and will show the feasibility of its concept in two different areas: Konstanz in Germany and the Province of Caserta in Italy. At these trial locations, which are rather different in terms of population, sun, andavailable equipment, CoSSMic will investigate how to motivate people to participate in acquiring (more) renewable energy and the sharing of renewable energy in the neighbourhood, and test methods for making money with these schemes.<br/>
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Deconstructing in vivo glia-to-neuron conversion' in the context of a Horizon 2020 call.

assistant: **Objectives**

Direct lineage reprogramming of cell identity in the nervous system offers the prospect of remodelling diseased brain circuits. Recent years have provided evidence for the possibility of converting brain glia into neurons in vivo. This may eventually allow to regenerate neurons that have degenerated as a consequence of injury or disease. Yet, the process by which glial cells give up their original identity and adopt a neuronal fate remains by large enigmatic. Moreover, the knowledge of molecular underpinnings of glia-to-neuron conversion is lacunary and virtually nothing is known about the process in vivo. The Berninger laboratory has discovered specific cocktails of reprogramming factors that gives rise to induced neurons in the mouse cerebral cortex, with some cells adopting hallmark features of fast-spiking, parvalbumin-expressing interneurons, a neuronal subtype that is highly vulnerable in neuropsychiatric and neurological disorders. The aim of my project addresses the question of how these neurogenic reprogramming factors remodel gene expression programs as glial cells convert into neurons. Thus, I will utilize defined combinations of reprogramming factors leading to the generation the distinct types of neurons to elucidate how and when the reprogramming trajectories diverge. Towards this end, I will establish single cell RNA sequencing as well as scATAC-seq from cells undergoing conversion in vivo to uncover the transcriptomic and epigenomic changes that drive this process. The outcome of this study is twofold, as this will break new ground in our understanding of how transcription factors can overcome existing cell-specific gene expression programs to induce new cellular identities, and at the same time identify new molecular handles for rendering reprogrammed c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'GALILEO SAR Early Service Demonstration' (GSARSED).

assistant: **Innovation**

SAR/Galileo system has achieved the required performances proposed in the previous GISAR FP6 project. The following reasonable step is the demonstration of the service to final customers using the complete architecture. The partners responsible for different components of the SAR/Galileo will ensure that demonstration covers the complete service.The following points summarise the envisaged objectives to be accomplished during the GSARSED activities:•Early Demonstration of the Forward and Return Link Service functionalities proposing a set of suitable scenarios. After this demonstration, the SAR/Galileo Service will become the first operative service of Galileo. These demonstration activities are based on the SAR community feedback from the SAR/Galileo RLS Survey Report.•Interoperability has to be demonstrated with Intergovernmental SAR Satellite Systems (such as GPS/DASS or SAR/Glonass).•Contribution to the Cospas-Sarsat MEOSAR Demonstration and Evaluation (D&E) Phase implementing a complete demonstration collection of the service.•Integration of SAR/Galileo infrastructure in the Cospas-Sarsat MEOSAR Service. SAR/Galileo will offer considerable benefits to the global SAR service provided by the current Cospas-Sarsat system.•Wide dissemination activity that implies the demonstration of service contributing to a gradual inclusion of navigation services and rescue operations based on Galileo infrastructure.GSARSED will achieve these objectives thanks to the experience obtained from projects like GISAR FP6, and making use of the knowledge of the SAR/Galileo system and service. For analysing the FLS and RLS functionalities an incremental set of demonstrations will be performed. Previous operational prototypes, such as MEOLUT and RLSP prototypes, will be used in the early dem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of Microsystems for In-Vivo Human Gene Therapy' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The objective is to develop a non-surgical treatment for oesophageal cancer - A microelectrode-based microsystem for use in vivo with an endoscope. This will be useful for the electroporation of tumours in order to deliver effective gene therapy. We will use 3 types of electrodes. Such a non-surgical cancer therapy will be very welcome progress in the fight against oesophageal cancer, improving the treatments currently available (both in terms of localisation of the gene delivery and greater comfort for the patient), and increasing patient survival rates. The consortium has the necessary wide-ranging experience in electrode and instrumentation fabrication as well as systems integration into endoscopic catheters. One of the partners is a cancer research centre, where the system will be tested and optimised.Objectives:Current cancer treatment uses 3 main modalities alone or in combination: chemotherapy, radiotherapy and surgery. Each of these carries associated morbidity and mortality with increased demands on healthcare services.The project will produce a non-surgical means of treating oesophageal cancer through increased functionality of endoscopic catheters by developing electrode systems for gene therapy. We wish to explore techniques where both diagnosis and treatment of cancer is minimally invasive. These techniques allow gene therapy via endoscopic access, directly to the site of the tumour, or into an easily accessible muscle for systematic delivery. The development will consist of electrode arrays on silicon and flexible substrates, incorporated in a microsystem, which can be integrated with an endoscopic catheter including control instrumentation. This product will facilitate the electroporation of tumour cells in order to deliver the effective gene therapy.Work
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High resolution nanoscale study of the smectite-chlorite transition.' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Smectite clays are a candidate for use as backfill materials in the construction of high-level nuclear waste repositories because of their swelling, hydraulic and sorption properties. However, their stability is not ensured after the predicted evolution of thethermo-physico-chemical conditions of a storage site. According to the observation of natural geological systems, smectites could partly transform to chlorites and consequently lose their sealing capacities. The prediction of the transformation of smectite, its kinetics and implications to the repository site requires a detailed knowledge of the smetite-to-chlorite mechanism and the different parameters involved. Different mechanisms have been proposed from the observation of natural samples, but the parameters could not predetermine precisely. The objective of this proposal is to use experimental samples to determine the mechanism of the smectite-to-chlorite transition at the particle nanometre scale by using two different high resolution instruments:( i ) Transmission Electron Microscopy in which High Resolution imaging, Energy Filtered imaging and Electron Energy Loss Spectroscopy can be carried out, and(ii) Atomic Force Microscopy. The advantage of experimental samples is that the conditions are well calibrated and can be modified to test the influence of different parameters. The Host Institute is involved in microscopic studies of transformation processes I using Transmission Electron Microscopy and Atomic Force Microscopy. This combination is a powerful and novel way to study the mechanisms of mineral transformations, since information about the surface structure; the chemical changes taking place, as well as any surface reconstruction can be obtained. These techniques are necessary for me to extend my Ph. D
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Understanding the drying behavior of polymer-coated particle dispersions using optical tweezers' to be submitted under Horizon Europe.

assistant: **Abstract**

After spilling coffee, a tell-tale circular stain is left by the drying droplet. This universal phenomenon, known as the coffee ring effect, is observed independent of the dispersed material. However, for many technological processes (e.g., coating and ink-jet printing) a uniform particle deposition is required and the coffee ring effect is a major drawback. In preliminary work, I found that the coffee ring effect can be avoided by coating the dispersed particles with surface-active polymers, which leads to a homogeneous particle film independent of the dispersed material type, shape and liquid. The aim of the project ""CoffeeRings"" is to provide a fundamental understanding on how the physio-chemical properties of the polymer coating affect the interactions of the particles and the drying behavior of the respective particle dispersion.I will receive hands-on training on optical tweezers by the hosting group to fundamentally determine and systematically quantify the changes induced by the polymer coating throughout all stages of the drying process with single-particle resolution. In WP1, I will synthesize a series of model particles with a defined polymer coating and adjust polymer type, grafting density and chain length. In WP2, I will use optical tweezers to measure their interaction potential in bulk liquid, their adsorption rate to liquid interfaces, and their interaction potential when confined at liquid interfaces, which will mimic the involved interactions within drying dispersion droplets. In WP3, I will investigate the drying behavior of the particle dispersions and combine the macroscopic drying manifestations with the microscopic interactions determined in WP2.The successful realization of this project will improve the compositions of particlepolymersolvent m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Evolution of pro- and eukaryotic commensals within the human gut'.

assistant: **Objectives**

The EPYC project will characterize the evolution of long-term human associated eukaryotes and prokaryotes, using colonization patterns in 3 human generations.The gut microbiome is important for human health, supporting nutrition, pathogen defence and immune homeostasis, with more than 200 species inhabiting each human gut. In recent years metagenomics led to notable breakthroughs in describing this microbial diversity, yet 50-90% of species are typically present at too low abundance to be genome or strain resolved. Thus, most gut microbiome studies focused to date on dominant bacteria and very little is known of the highly diverse, yet low abundance, pro- and eukaryotes (elusive microbes).  Importantly, elusive microbes are an inherent part of ecosystem successions persisting at different ages of the host. I propose that niche adaptation and persistence are key indicators of a taxa’s importance to the gut ecosystem and host health. I will determine which microbes persist for years within a human, or even a family for several generations. This should be reflected in microbial genetic adaption, also indicating which genes are likely important to successfully colonize the human gut. I hypothesize that low abundance pro- and eukaryotes are adapted to persist for multiple generations in the human host, indicating their importance, despite being largely ignored so far.To investigate this knowledge gap in EPYC, I will(O1) Enable high-precision metagenomics of elusive microbes (O2) Estimate pro- and eukaryotic strain persistence across three human generations(O3) Describe the microbial genetics of gastrointestinal persistenceEPYC will develop the next-generation of high-resolution metagenomics of an extended taxonomic range, enabling me to research microbial evolution in the hu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Selection and evolution of phage-encoded anti-CRISPR genes' (2014-2020).

assistant: **Innovation**

CRISPR-Cas immune systems protect bacteria against their viruses (phage). However, some phages encode anti-CRISPR (Acr) genes that block CRISPR-Cas activity. While the molecular understanding of Acr activities and structures are racing ahead, their impact on the ecology and evolution of phage/bacteria populations remains unexplored.I first aim to identify the ecological factors that influence the selection for Acr genes, to explain why some phages encode many Acr whereas most encode none. Next, by running long-term co-culture experiments, I will examine whether CRISPR-Cas can evolve to escape Acr inhibition and whether Acr genes can reciprocally adapt to restore activity. These experiments will reveal how CRISPR-Cas and Acr coevolve and allow to mathematically predict the long-term stability of Acr activity.  I will also explore the genetic bases of this coevolution through deep-sequencing analyses.This multidisciplinary project combines my expertise in phage biology, that of the host in experimental evolution and bioinformatics and that of collaborator in mathematical modelling. It is expected to open new avenues of research for downstream medical and bioengineering applications. This high-quality 'training-through-research' will allow me to widen my scientific expertise, develop essential complementary skills and constitute an international collaborative  network. The visibility and impact of this research will be increased by a strong dissemination and communication plan. I also aim to reinforce my public engagement activities with a dual objective of making science accessible for everyone and inform about phage research. Carrying out this project within the Centre for Ecology and Conservation at the University of Exeter (EU accredited), a top department in ecology a