RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Understanding the mechanical control of cell extrusion in collective assemblies', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Epithelia are assemblies of multiple cells whose complex dynamic behavior relies on physical properties including jamming-unjamming mechanisms, active turbulence and active nematic principles. The homeostasis of epithelia is crucial to maintain barrier function and integrity while epithelial cells are constantly challenged by the environment. To face these challenges, epithelia are dynamics and have to deal constantly with cell renewal and apoptotic extrusion, whose balance is key for epithelia homeostasis. On top of this role in tissue homeostasis, cell extrusion is a major cause of tissue shape changes and tumor progression. Extrusion mechanisms can thus lead to different cell fates namely dead or live cells but the factors selecting different cell fates are unknown. Extruding cells and their neighbors experience various mechanical stresses that lead to cell shape changes and could determine the way cells are extruded and their fate. However, these mechanical stresses and their impact on tissue organization remain to be determined.From our recent study on emergent active nematic properties of epithelia, we hypothesize that mechanical constraints coming from the active forces generated by neighboring cells and the passive physical properties of the environment can determine the modes of cell extrusion and the fate of extruded cells. Here we propose to tackle the molecular mechanisms and physical principles that determine the manner by which cells are extruded and the collective response of surrounding cells, and to evaluate their contribution in tissue homeostasis, morphogenesis and tumor progression. By combining tools from soft matter physics, cell biology and engineering, our project will reveal how active and passive physical signals are overarching components of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Secure & Interoperable Networking for Contactless in Europe' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The project has 3 main goals:- To promote the proliferation of contactless technology,- To harmonise the contactless infrastructure and ensure the interoperability of systems,- To stimulate the use of contactless technology through education. Directly linked to the trailblazer 6 created inside eEurope smart card initiative, the partnership between operators and manufacturers will work inside the SINCE framework providing all the tools to achieve the 2 years objectives.OBJECTIVESThis project's primary objective is to promote the widespread uptake of contactless smartcards. Currently, a number of factors are hindering the proliferation of this key emerging technology and the aim is to identify and find solutions to these problems. SINCE will provide the framework of eEurope Smart Card Charter Trailblazer 6.DESCRIPTION OF WORKThe project is broken down into several key parts, including promotional/educational activities and a set of reports/white Papers into the current state of the art, analysis and identification of necessary improvement, and proposed solutions.WP1 Foundations: In order to build on contactless smartcard technologies clear technological advantages, participants need to develop the mutual knowledge and understanding of their key problems facing contactless technology proliferation. Reports will be published.WP2 Promotion/Education : The main task is to centralise, harmonise and publish the existing capital of the projet partners.WP3 Management : provides the necessary tools for the SINCE partners to ensure the required quality and follow-up to make this project successful. It also ensures a very good liaison between the members of TB6. The strategic relevance of the project is its supporting role in the European (e-Europe, Smartcard Charter) effort towards
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Programmability In RINA for European supremacy of virTualised NEtworks' (PRISTINE), addressing dissemination and exploitation.

assistant: **Impact**

The Internet as the global communications infrastructure has been successful in shaping the modern world by the way we access and exchange information. The Internet architecture designed in the 1960's has been supporting a variety of applications and offering a number of services till now but emerging applications demand better quality, programmability, resilience and protection. Any alterations to the Internet architecture have become restricted to simple incremental updates and plug-ins instead of radical changes by introducing new solutions. RINA is an emerging clean-slate programmable networking approach, centring on Inter-Process Communication (IPC) paradigm, which will support high scalability, multi-homing, built-in security, seamless access to real-time information and operation in dynamic environments. The heart of this networking structure is naturally formed and organised by blocks of containers called Distributed Information Facilities - DIFs" where each block has programmable functions to be attributed to as they required. A DIF is seen as an organizing structure, grouping together application processes that provide IPC services and are configured under the same policies. Virtualization is a fundamental attribute of the architecture itself. Based on the above fundamental aspect, PRISTINE intends to: Design and implement the innovative internals of this clean-slate architecture that include the programmable functions for: security of content and application processes, supporting QoS and congestion control in aggregated levels, providing protection and resilience, facilitating more efficient topological routing, and multi-layer management for handling configuration, performance and security. Demonstrate the applicability and benefits of this approach and it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Biomolecular Electronics and Electrocatalysis' in the context of a Seventh Framework call.

assistant: **Objectives**

The objective of the joint exchange programme BIOMOLECTRONIC (Biomolecular Electronics and Electrocatalysis) is to strengthen existing scientific collaboration between two EU partners and a third country (Argentina) partner in the field of biomolecular electronics and electrocatalysis. The topic of research is the multidisciplinary approach to study strategies of electrode surface modification with redox molecules and redox biomolecules integrated in electronic and electrocatalytic devices with applications in the areas of molecular electronics (molecular transistors), integrated biosensors and electrocatalysis in biofuel cells. The programme encompases the synthesis of novel redox molecular systems, strategies for surface modification, theoretical modelling and use of electrochemistry and surface vibrational spectroscopy (Surface enhanced Raman –SERS- ; Surface enhanced Resonant Raman –SERRS and Polarization Modulation Infrared Reflection Absorption spectroscopy-PM-IRRAS). The exchange programme consists of short visits of four senior researchers in each other partner group to provide a lecture course for students and staff, three 12 month exchanges of postdoctoral fellows with special skills and experience to be complemented in the partners group with their own specific developments, and exchange of six PhD students who will benefit both from the scientific and cultural exchange in the other partners group.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Knowledge For Use [K4U]:  Making the Most of Social Science to Build Better Policies' (K4U).

assistant: **Concept**

‘Research is an investment in our future’ says Horizon 2020.  That’s only true if you know what to do with it.  When it comes to social policy, we don’t really know how to put our research results to use. K4U aims to remedy this. K4U will construct a radically new picture of how to use social science to build better social policies. This picture will be founded on an ambitious philosophical study of the technology of social science including a thorough reconceptualisation of objectivity, deliberation and the role of values in the science/society interface. Current work, primarily by the evidence-based policy and practice movement, focusses on knowledge production: encouraging high quality studies and vetting them. Little attention goes to knowledge use: How is social science knowledge to be used in policy design and deliberation – how should it be used so that policy outcomes are more effective and more reliably predictable and competing values and points of view are respected in policy choice and implementation? K4U will provide not just a theoretical but a practical understanding— for users: intelligible and practically helpful to those who need to estimate and balance the effectiveness, the evidence, the chances of success, the costs, the benefits, the winners and losers, and the social, moral, political and cultural acceptability of proposed policies.  The philosophical approach of K4U is broadly Popperian. It views ‘science and technology as a means of understanding social problems and responding to them’ and it emphasises the concrete and detailed, where the real content of general philosophical concepts and claims is embodied and interrogated. K4U is a showcase for the kind of philosophy that makes a difference to real life -- philosophy for practice. And it will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'European Platform Driving KnoWledge to INNovations in Freight Logistics'.

assistant: **Innovation**

European Platform Driving KnoWledge to INNovations in Freight Logistics-WINN is a step forward to increase collaboration and consensus building of the different stakeholders dealing with freight transport and logistics to define and implement research and innovation measures (including policy) that may be implemented through the HORIZON 2020 and member states programs in the medium-long term in the field of logistics.Estimates put the share of the logistics industry in Europe at close to 14% of GDP and the logistics industry has had growth rates above the average of European economies. Moreover, six countries out of the global top-10 logistic performers are from the EU in 2012. This basic data support the idea of a potential worlwide leadership of the European logistics industry that will also benefit the competitivenes of the industrial sectors  (automotive, food industry, etc.) in which logistics represents a major cost.The WINN project will establish a broad collaboration framework that will include, from the beginning, several main stakeholders operating at a European level (CO-Tree, EIRAC heritage) and national triple helix networks that currently operate in different countries in Europe: CNC-LOGISTICA (Spain), DINALOG (Netherlands) and ILiM (Poland and Baltic to Balkan countries). These networks mainly include excellence research centres, public bodies and industry operating in the logistics field. Manufacturing companies, retail, logistics services providers, transportation companies and logistics hubs and platforms (airports, ports, dry ports, etc.) are all represented in these networks. The collaboration framework will also include well known key stakeholders developing information and communication technologies for the logistics sector (BLUEGREEN and ENIDE). T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Reflection of polar molecules' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content The applicant intends to study the reflection of polar molecules to show the possibility of manipulating a molecular beam. The project is a direct application of recent results on oriented molecules obtained both by the laboratory of Steven Stolte and that of the applicant. The goal of the project is to develop suitable techniques so as to conserve the projection quantum | number M of the total rotational momentum J of the incoming molecule along its scattering path. This technique appears to be a critical issue in order to extend the reslts of atomic manipulation (such as Doppler cooling) to the rich molecular domain. In the planned experiments, the reflection will be produced by a specially designed electric field shaped by | microstructures. The desired interrogation f the M quantum number distribution upon the reflection will be obtained by | Laser Induced Fluorescence. This pilot study is an important step toward molecular trapping and nanoscale lithography. Training content (objective, benefit and expected impact) The applicant will broaden his scientific skills by learning the state-of-the-art technology on polarisation and orientation- conserving techniques, the speciality of the laser laboratory of the Steven Stolte group . The acquisition of this technique will be extremely useful when applying to a position in the field of nanoscale technology. Links with industry / industrial relevance (22) A direct application of such research is the focusing of molecules with (laser) fields. It should permit to control the orientation of molecules deposed in nanostructure, which has important applications in nanoscale lithography and electronics (Philips, Motorola, etc .)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Aerosol, Clouds and Trace Gases Research Infrastructure Implementation Project', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The Aerosol, Clouds and Trace Gases Research Infrastructure (ACTRIS) is a pan-European research infrastructure producing high-quality data and information on short-lived atmospheric constituents and on the processes leading to the variability of these constituents in natural and controlled atmospheres. Different atmospheric processes are increasingly in the focus of many societal and environmental challenges, such as air quality, health, sustainability and climate change. ACTRIS brings essential information for understanding atmospheric processes and bio-geochemical interactions between the atmosphere and ecosystems. ACTRIS is composed of Observational and Exploratory Platforms, Topical Centres, Data Centre, and Head Office that is coordinating the ACTRIS activities. ACTRIS serves a vast community of users such as scientists, policy makers, private sector, funding organisations and educators. ACTRIS activity started almost 20 years ago, and currently more than 100 European partners from 22 countries are engaged in building the research infrastructure. ACTRIS was selected to the ESFRI roadmap in 2016 and was granted with EC preparatory phase project funding (ACTRIS PPP) for 2017-2019. Interim ACTRIS Council (IAC), representing the governmental representatives of 16 member countries and one observer country, have submitted the ACTRIS ERIC step 1 documents to EC in Feb 2019. IAC is aiming to establish ACTRIS ERIC in 2021. ACTRIS is entering the implementation phase in 2020. The ACTRIS implementation project, ACTRIS IMP, will take ACTRIS into a new level of maturity and will set the needed structures for the implementation actions, both at the national and European level. ACTRIS IMP builds on three main pillars: securing the long-term sustainability, implementing of ACTRIS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Role of miR-129-5p and Rbfox1 crosstalk in neural network homeostasis' to be submitted under Horizon 2020.

assistant: **Abstract**

Imbalances between excitatory and inhibitory neural networks are a hallmark of several brain disorders including epilepsy. Current drug therapies for epilepsy are ineffective in a third of patients and none have disease-modifying effects. It is of high priority, therefore, to understand molecular/ genetic mechanisms responsible for epilepsy development and identify novel targets. The control of mRNA stability and translation is critical for proper neural network function. Here, RNA binding proteins (RBPs) and small noncoding RNAs called microRNAs (miRNA) act together to fine-tune levels of proteins critical for synaptic structure and function. These may represent important therapeutic targets since they regulate gene networks and exert broader actions that can generate more potent effects against seizures. Until now there has been no systematic analysis of miRNA, RBP crosstalk in the context of neural network stability in epilepsy. Building on my recent breakthrough studies showing miR-129-5p/Rbfox1 crosstalk in neural network homeostasis my project will explore the following objectives: First, identify targets regulated by miR-129-5p/Rbfox1 crosstalk in vivo; Second, functionally interrogate miR-129-5p/Rbfox1 crosstalk in neural network stability in vitro and in vivo; Third, investigate miR-129-5p and Rbfox1 function in human neural networks. To achieve these objectives I will apply my existing expertise as well as acquire new skills in a range of state-of-the-art interdisciplinary and cutting-edge techniques including single molecule imaging, proteomic analyses, multiple electrode arrays, human brain organotypic cultures and pre-clinical animal models. The results will establish RBPs, alongside miRNAs, as new mediators of epileptogenic network pathogenesis.  Findings
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Cloning of zebrafish craniofacial mutations. Their function in morphogenesis'.

assistant: **Concept**

We propose a detailed analysis of two zebrafish mutants with craniofacial and heart defects. Our goal is to isolate and characterize the mutated genes that are crucial for vertebrate development. The immediate goal for these two years is to map and clone the mutations and perform an extensive analysis of mutant phenotypes using in situ hybridizations, histological analysis and transplantation experiments. We will attempt to positionally clone the mutated genes using modern molecular genetic tools and taking advantage of the powerful techniques of zebrafish genetics. If novel genes are thus identified, their mammalian homologues will then be sought by in silico screening of EST databases. Molecular characterization of the genes will be completed and we will micro-inject DNA to mutant embryos to rescue the phenotype. We hope that this work will ultimately lead to a better understanding of the molecular and cellular basis of congenital human diseases of craniofacial structures and valve malformations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Identification and characterisation of genes controlling longevity and ageing in an animal model' in the context of a Fifth Framework call.

assistant: **Objectives**

Ageing is the single most important factor in the onset of disease in the European population. An understanding of the molecular and physiological mechanisms that cause ageing is essential for the rational intervention of age-related disease. Simple model systems that exhibit ageing provide and economical means to obtain this understanding. We shall determine the genes and physiological mechanisms that cause ageing in Caenorhabditis elegant with a view to targeting processes that underlie age-associated disease in humans. This will be achieved by an extensive, interdisciplinary analysis of a series of genetic variants that exhibit greatly slowed rates of ageing resulting in life span control ageing rate and 300% (Age mutants). This analysis will reveal both regulatory mechanisms that control ageing rate and downstream mechanisms that constitute the molecular and physiological causes of ageing. We predict that many of the mechanisms we uncover will be universally linked to ageing in all animals and that consequently the targeting of these mechanisms will ameliorate age-related disease or postpone its onset.