RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Serotonin at the epigenetic nexus of tumorigenesis in Epstein Barr lymphoma' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

The rising global incidence of Epstein-Barr virus (EBV)-related cancers highlights the urgent need to explore the mechanisms driving their pathogenesis. Many of these tumours are highly aggressive, with poor patient outcomes. The viral latent membrane protein-1 (LMP1) drives oncogenesis through poorly understood epigenetic mechanisms. Serotonin, which influences viral replication, has recently been linked to the regulation of gene expression in cancers via serotonylation, a newly discovered histone modification. However, whether serotonylation influences LMP1-driven oncogenesis remains unknown. Cancer-altered tryptophan metabolism reduces serotonin levels, partly through the recruitment of indoleamine 2,3-dioxygenase-1 (IDO1)-expressing macrophages that promote cancer progression, but it is unclear if viral factors are involved in their recruitment. Additionally, EBV binds to platelets, the body's richest serotonin source, though the significance of this interaction is also unknown. SENTINEL will adopt an interdisciplinary approach, integrating virology, epigenetics, immunology, and platelet biology to shed new insights into EBV driven cancer development. The fellowship comprises three research objectives (work packages WP1-3): WP1 will identify cellular and viral genes influenced by serotonylation, WP2 will examine EBV’s role in recruiting IDO1+ macrophages, and WP3 will investigate how platelets and platelet-derived serotonin regulate EBV’s life cycle. This research is a collaboration between leading experts in virology, epigenetics, immunology, and cancer biology, providing the Postdoctoral Fellow with a unique set of training opportunities in preparation for an independent research career. In uncovering novel tumorigenic mechanisms, the project is expected to pave t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'First modular, interconnected, data- and AI-driven software platform for the digitisation of patient care in the healthcare industry' (2021-2027).

assistant: **Concept**

In Europe, there are 36.6 doctors and 83.3 nurses per 10,000 inhabitants. Both professional groups spend 169 minutes of their working time every day on administrative tasks as patient care is not properly digitized. With our modular platform, we offer the first plug & play solution to digitise the entire patient documentation & treatment process while simultaneously automatically generating fully structured medical data. It is the first holistic approach that networks all hospital departments, connecting more than 40 operable applications. On the basis of the unique structured data, we develop a workflow engine that fully optimises and automates the treatment process as well as an AI-based diagnostic support system that assists doctors and nurses in diagnosis and treatment. Our software saves up to 10 minutes on administrative tasks per patient treatment and drastically improves the quality of care.


**Keywords:** Artificial intelligence,electronic health record,patient health record,eHealth,Machine learning,Statistical data processing,Digital services,digital health
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Role of skin dendritic cells in stimulating immune responses initiated in skin'.

assistant: **Innovation**

Dendritic cells in peripheral immune organs are quiescent sentinels that continuously survey their surroundings by fluid phase uptake and endocytosis. Dendritic cells become activated when pathogen-derived fragments are detected. Engulfed material is now processed into peptides and lipids for incorporation into peptide/MHC or lipid/CD1 complexes, for display to MHC- and CD1-restricted T cells respectively. The presentation of antigen to T cells is regarded the initiation of immune responses. Much of what we know about the intracellular antigen processing and loading has been obtained from biochemical and cell biological analysis of B cell lines, and to a more limited extent, of cultured dendritic cells.New methodology now makes it possible to visualize the uptake of fluorescent antigen by live Class II MHC-positive dendritic cells in situ without the need for fixation or staining, by analysis of dendritic cells in the epidermis of mice that carry fusion proteins composed of Class II MHC molecules and green fluorescent protein. We will study the protein and lipid antigen-presentation pathways in skin-derived dendritic cells. We propose to study the importance of antigen entry into specialized endosomal compartments in prototypic immature dendritic cells in situ, by analysis of Langerhans cells in epidermis.The loading of lipid antigens in late endosomal compartments in primary cells has not been explored to date, due to the unavailability of suitable mouse models. We have very recently succeeded in the generation of novel fluorescent knock-in mice in which we shall study the intracellular trafficking routes of membrane protein CD1d.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Browsing, listening, interacting, performing, sharing on future HIFI systems' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

In the context of large scale digital music, the goal of the project is to develop a new generation of HIFI systems, offering new functionality for browsing, interacting, rendering, personalizing and editing musical material. This next generation of Hard-disk based HIFI systems will change drastically the relation of home users to music and multimedia content. Users will be able to interact with music up to the point of blurring the traditional limits between playing, performing and remixing. These HIFI systems will be listening stations as much as open instruments. Technically, with IPv6, every HIFI system will have an IP address and systematic use of metadata extraction and exploitation techniques will allow semantic or thematic browsing in large content catalogues over Web and file sharing systems. Converging with the TV, DVD, Game Station and 5.1 set-ups, HIFI systems will also bring 3D audio real-time navigation in the sound scene.The main innovations include a deeper access to the audio content and structure, through state-of-the-art semantic musical metadata extraction and exploitation (partially from MPEG-7): temporal segmentation, polyphonic, melodic, and high-level descriptions like genre, etc. Users will be offered innovative possibilities of manipulation, edition, re-composition, organization, sharing and interactivity with the audio material, and true 3D audio rendering and real time remixing of music.Using music from CDs, consumers will be able to freely exchange metadata information enriching their music and allowing them to listen to remix sessions performed by other users. But with appropriate DRM systems sharing music files is also possible and may even support new profitable music business models for the music industry. Bringing together leading Europ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Marie curie fellowships in crystallographic methods for crystal structure determination' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The National Research Council (CNR), through IRMEC (Research institute for the development of crystallographic methods) is offering some fellowships mainly focused onto the study and development of crystallographic methods. An opportunity of training in this area will be offered to post-graduate fellows in Physics, Chemistry, Geological Sciences to improve their knowledge of methods and techniques in crystallography. Their activities will be focused mainly on crystal structure solution, powder diffraction data analysis, and properties of policrystalline materials, quantitative analysis and study and development of techniques for proteins structure determination. The fellows will be hosted at CNR IRMEC, a Institute of the Italian National Research Council, where they will join a group of researchers and PhD students. Fellows will be expected to attend and to give seminars and to be fully integrated into the scientific activities of the Institute, having thus the opportunity of joining one of the major European groups in crystallography, with an outstanding research reputation.Research opportunities will be offered in the following areas :- development of new methods for abinitio crystal structure solution (small- and macro-molecules);- study and development of MIR (multiple isomorphous replacement) and MAD (multiple wavelength anomalous dispersion) techniques for proteins;- development of innovative techniques for the treatment of powder diffraction data.Methods for crystal structure solution, completion and refinement are also developed;- quantitative analysis in terms of crystalline phases from powder diffraction data (Rietveld Method);- development of software packages which implement the theoretical results. The CNR IRMEC institute is located in Bari, Italy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Uncovering conserved proliferation pathways between plants and animals'.

assistant: **Innovation**

The study of plant biology is useful in two ways. Under a basic research perspective, it yields basic knowledge on processes that are specific to plants and distinguish them from animals. From an applied perspective, this knowledge can lead to an improvement in the quality or the productivity of crops. Any given aspect of plant biology can be considered to be fully dissected only after the genes that control it have been identified, which makes its eventual controlled perturbation possible. Plant genetic research can also help to understand the conserved functions of such genes in different organisms as well as to establish their biotechnological potential. In this proposal, I aim (1) to identify genes important for leaf morphogenesis in the model plant Arabidopsis thaliana, as inferred from the effects of their loss of function on cell size and cell number; (2) to characterize the effects of their constitutive expression in Arabidopsis thaliana, in order to assess their potential application as plant growth modulators; (3) to characterize the effects of their heterologous expression in an animal model system (Caenorhabditis elegans), in order to assess their potential pharmacological use and the eventual conservation of their functions in the control of cell proliferation; and (4) to knock down the putative orthologs of these genes in Caenorhabditis, in an attempt to establish their potential use as regulators of cell proliferation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Systematic Approach to Dissect the Interplay between Chromatin and Transcription' (CHROMATINSYS) targeting Seventh Framework.

assistant: **Abstract**

Epigenetic mechanisms play an important role in regulating and maintaining the functionality of cells and have been implicated in a wide range of human diseases. Histone proteins that form the protein core of nucleosomes are subject to a bewildering array of covalent and structural modifications, which can repress, permit, or promote transcription. These modifications can be added and removed by specialized complexes that are recruited by other covalent modifications, by transcription factors, or by the transcriptional machinery. Advances in genomics led to comprehensive mapping of the ``epigenome'' in a range of tissues and organisms. These maps established the tight connection between histone modifications and transcription programs. These static charts, however, are less successful at uncovering the underlying mechanisms, logic, and function of histone modifications in establishing and maintaining transcriptional programs. Our premise is that we can answer these basic questions by observing the effect of genetic perturbations on the dynamics of both chromatin state and transcriptional activity.  We aim to dissect the chromatin-transcription system in a systematic manner by building on our extensive experience in modeling and analysis, and a unique high-throughput experimental system we established in my lab.We plan to use the budding yeast model organism, which allows forefficient genetic and experimental manipulations. We will combine two technologies: (1) high-throughput measurements of single-celltranscriptional output using fluorescence reporters; and (2) high-throughput immunoprecipitation sequencing assays to map chromatin state. Measuring with these the dynamics of response to stimuli under different genetic backgrounds and using advanced stochastic network mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ready-to-use Multilingual Linked Language Data for Knowledge Services across Sectors' (Pret-a-LLOD).

assistant: **Concept**

Language technologies increasingly rely on large amounts of data and better access and usage of language resources will enable to provide multilingual solutions that would support the emerging Digital Single Market in Europe. However, data is rarely ‘ready-to-use’ and language technology specialists spend over 80% of their time on cleaning, organizing and collecting datasets. Reducing this effort promises huge cost savings for all sectors where language technologies are required. An essential part of the Extract-Transform-Load process involves linking datasets to existing schemas, yet few specialists take advantage of linked data technologies to perform this task. In this project we aim to increase the uptake of language technologies by exploiting the combination of linked data and language technologies, that is Linguistic Linked Open Data (LLOD), to create ready-to-use multilingual data.  Prêt-à-LLOD aims to achieve this by creating a new methodology for building data value chains applicable to a wide-range of sectors and applications and based around language resources and language technologies that can be integrated by means of semantic technologies, in particular the usage of Linguistic Linked Open Data (LLOD). The project will develop novel tools for the transformation and linking of datasets, and apply these to both data and metadata in order to provide multi-portal access to heterogeneous data repositories. We will study how we can automatically analyze licenses in order to deduce how data may be lawfully used and sold by language resource providers. Finally, we will provide tools to combine language services and resources into complex pipelines by use of semantic technologies. This will lead to sustainable data offers and services that can be deployed to many pl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Interconnecting Histories and Archives for Migrant Agency: Entangled Narratives Across Europe and the Mediterranean Region'.

assistant: **Innovation**

Based on a consortium involving 12 partners from origin, transit and host migration countries in Europe, Africa, Middle East and Eurasia, the ITHACA project focuses on migration narratives in the past and present, analysing them in a rigorous historical framework, whilst adopting an interdisciplinary, comparative and transnational approach. The aim is to define and develop concrete actions of migration management, moving away from an emergency logic and basing the choices of practitioners and policy makers on a triple basis: 1) a long-term multi-layered historical appraisal (global, oral, digital, gender, socio-economic, and religious), with an archival focus on the collection and preservation of endangered migrant records; 2) the analysis of the multiple and contrasting forms taken by narratives on migrations; 3) the attentive listening and interpretation of expectations and experiences of the migrants themselves. At the heart of the project is the creation of a digital platform collecting databases on past and present migration narratives, and offering media tools and applications to policymakers, practitioners, and migrants. Through archival surveys, research-action, and participatory, artistic and training activities, the ITHACA project deepens the various forms of narratives on and by migrants, considering them as agents of social change, retracing causes, transformations, and effects of migration narratives, and highlighting silenced expressions. Finally, the ITHACA stakeholders engagement activities interconnect scholars, archivists, museum curators, practitioners, ngos, returnees and potential migrants. These actions intend to raise awareness, to inform the public debate, and to disseminate thoughtful recommendations for present and future policies of relief, em
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sea Level Rise Impacts on Italian Hospitality' (SEA-LIMITHS) targeting Horizon Europe.

assistant: **Abstract**

There has been no evaluation of the economic and environmental impacts of coastal sea-level rise on the hotel industry utilising Artificial Intelligence (A.I.) to analyse the whole transmission channel. The SEA-LIMITHS project will contribute to the expanding but still limited body of information on climate change and tourism losses. Despite the importance of sand beaches to the hotel sector in the vast majority of Italian beaches, tragically few policymakers incorporate quantifiable risk assessments of sand beach loss due to climate change. This study investigates the impacts and economic consequences of sea level rise on sandy beaches and beach hospitality losses owing to beach erosion and flooding in two economically important Italian coastal areas, Veneto and Emilia-Romagna. Combining sandy beaches with a proposed rich dataset based on machine learning and artificial intelligence, user-generated data is matched to the land cover/land use map to separate the hospitality sectors (accommodation, food and drink, sports and leisure) in order to assess economic losses in the hospitality industry from 2050 to 2100 using representative concentration pathways (RCP 4.5 and RCP 8.5). Taking into consideration no adaptation measures, the predicted cumulative damage costs per hospitality industry are analysed and contrasted to the investment cost of adopting alternative adaption solutions. Using an Italy-specific computable general equilibrium model, the estimated direct costs will be used in a macroeconomic assessment as input to determine how changes in hospitality activities effect regional value added. The fact that this proposal pertains to several disciplines of study is what gives it its creative interdisciplinarity. The combination of economic and environmental research,