RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'T cell receptor αβ : in control of signal initiation and T cell fate' under Seventh Framework.

assistant: **Concept**

One of the central mysteries of immunology is self-tolerance. How does the human body select ~10e12 T lymphocytes, that are reactive to foreign pathogens but tolerant to normal cellular constituents of the host? Over the last few years, my laboratory identified 2 fundamental mechanisms used by thymocytes to establish T cell tolerance. We demonstrated that the affinity threshold for negative selection is a constant for all thymocytes expressing MHC I restricted TCRs. This binding affinity threshold (KD H 6 ¼M; estimated T1/2 H 2 sec) is the fundamental biophysical parameter used by TCRs to delete autoimmune T cells. We also established how the TCR generates distinct signals for positive and negative selection. At the selection threshold, a small increase in ligand affinity for the T-cell antigen receptor leads to a marked change in the activation and subcellular localization of Ras and mitogen-activated protein kinase (MAPK) signaling intermediates. The ability to compartmentalize signaling molecules differentially within the cell endows the thymocyte with the ability to convert a small change in analogue input (affinity) into a digital output (positive versus negative selection) and provides the molecular basis for central tolerance. In the present application, we plan to fully understand 1-how the biophysical events during antigen binding to the TCR initiate an intracellular signal; 2-how these signals program an unambiguous cell fate and 3-how the system fails, when an autoimmune T cell is generated and activated. We will use a combination of transgenic and knockout mice, biochemistry and molecular imaging to fully define how the TCR functions as a molecular switch.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Open Network for Connecting Excellence in Complex Systems', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The science of complex systems is crucial to FET and the economic success of Europe. But complex systems research is still not well coordinated in Europe, with urgent need to connect and expand the community.This three-year CA coordinates and integrates scientific research and dissemination in the European CS community by:(i) identifying fundamental questions across CS in all areas of application, in order to ground the new science,(ii) encouraging and facilitating research collaboration around the fundamental questions, to stimulate research and applications across academic disciplines, industry and government,(iii) establishing sustainable cross-disciplinary education in CS science,(iv) coordinating the creation of a European PhD in CS science,(v) supporting European Centres of Excellence in CS science,(vi) providing network infrastructure for the new Integrated Projects and connecting them and the CS community, and(vii) coordinating the formation of a vigorous self-sustaining European Complex Systems Society (ECSS), to take over the networking and coordinating roles of Exystence and ONCE-CS.All this is enabled by (viii) the provision of a robust and well-designed Internet portal providing many delivery, retrieval, communication, and management services.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Moving Marketing Technology (MMT) – Autonomous infotainment display that creatively combines digital media with robotics to produce innovative public engagement'.

assistant: **Innovation**

As a world first, IBG have already presented our sensational development: Moving Technology, a unique combination of robotic technology and customisable marketing system, alongside our exciting gesture control robotics at various fairs by Panasonic, VW and Hannover Messe, etc. with great success.Building on this, MMT is a customisable mobile information and advertising robotic display that is designed to autonomously move through public spaces, allowing promoters and advertisers to engage with audiences in new and innovative methods. As a highly innovative technology, we fully expect for MMT to advance the digital signage industry as well as create new markets.We envision for the sensational MMT technology to be used at destination locations such as airports, shopping venues and sporting/event arenas, used for:- providing bespoke information/assistance to visitors- directing crowds foot-flow- meet-and-greet visitors to sites such as hospitals or universities- product marketing, reaching customers in a new highly engaging and eye-catching wayAs the first of its kind and with our IP position protected, we intend for MMT to become the industry standard and launch us into becoming a digital signage market leader, therefore, it is key for us to plan this market entry strategy carefully to ensure success is maximised. This feasibility study will allow us to: refine our market knowledge; scope the legislative pathway; finalise Phase 2 project partners; plan the work to be completed during Phase 2 and produce a fully elaborated business plan.Building on our legacy as an innovative company, at IBG, we possess the know-how necessary to develop, manufacture and market such world novelties and innovations. Having already proven TRL6, at Phase 2 we shall: finalise chassis developmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Lens that mIGHT be a Satisfactory Way Of Reducing age Degradation of Sight', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Ageing of society is an issue of increasing importance for Europe. According to Eurostat, 36,5% of the European population is more than 50 years old and this percentage is constantly growing. In the next decades, Europe’s growth will increasingly depend on the ability to capitalise on the skills of ageing people: the goal set by EU for 2020 is to achieve an employment rate of 50% for older workers (55 to 64). One of the most common diseases associated with ageing is the decline in the quality of vision. In the framework of an ageing society and higher retirement age more and more workers will require these problems to be addressed, especially when wearing protective glasses. Protective glasses with prescription lenses exist, but they suffer several major drawbacks related to cost and usage, in particular related to the difficulty of focalising on different distances, exposing workers to potential risks. LightSWORDS aims at developing an innovative non-symmetrical plastic lens allowing for continuous focal adjustment between near field and infinity, thus able to compensate different presbyopia and myopia disorders with a one-solution-fits-all approach. The lens is static and does not require any movement and/or stressing while using, moreover it is projected to be considerable less expensive than currently available ones. Other applications are found in security cameras and prescription glasses. LightSWORDS is based on the positive testing of a first initial prototype developed by the SME proposers in the past two years; according to the literature and market research performed by project proposers, this is the only element known up to date that can form recognizable images of objects situated at any distances between 25 cm and infinity in real operative conditions. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Microfluidic Active Pharmaceutical Ingredients Capture (MAPIC) System' to be submitted under Horizon 2020.

assistant: **Abstract**

This project aims at tackling pharmaceutical micropollutant capture (antibiotics, endocrine disruptors,…) from wastewater by developing a small, energy-efficient, high capture efficiency device that couples microfluidic technology  with β-Cyclodextrin polymer (β-CDP). β-CDP was recently shown to outperform all other adsorbants in water depollution test. Yet, like all adsorption methods, β-CDP efficiency is dependent on required elapsed time for interaction events to occur  in  between flowing pollutant and the adsorbant surface. This can be greatly improved by using microfluidics systems which reduce drastically both the diffusion distance and the related time while significantly minimizing the overall footprint. The proposed highly integrated microfluidic architectures target to treat up to 50 m3/day, and unlike conventional methods uses minimal energy (<200Pa). The modular assembly will also enable multiplexed capture approaches through serial configuration. This project will pave the way towards further possibilities for applications in biosensing, solvent recovery, and others fluid system remediation (Air, Gas, oils, etc,…).With the support of Blackholelab and its owned IP, two remediation demonstrators will be realized for domestic and industrial perspectives, with respectively targeted sizes of a Soda-Can and a suitcase.  This innovative solution to remove pharmaceuticals from wastewater can help in tackling some of our greatest challenges: water scarcity, energy saving, and antibiotic resistance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Tool for the Analysis of Information Transfer in Manuscript Cultures' (TInTraMaC) targeting Horizon Europe.

assistant: **Abstract**

This PoC project aims to alleviate the hesitancy of scholars working on texts preserved in manuscripts or other handwritten media, to adopt advanced digital methodologies in their research, by developing a free, shareable, flexible, low-threshold research tool, which may be used as a starting point for researchers interested in studying the textual transmission of information in manuscript cultures. It will take the form of a pre-designed but flexible data model, data-input framework, and database solution, through which data can be queried and exported for further analysis using relevant tools for statistical and network analysis. It will be accompanied by a detailed user manual guiding users through the workflow from data input to analysis, and tutorial videos explaining in non-specialist terms to scholars of historical textual corpora the procedures leading from database design and population to the application of relevant analytical tools. It will also contain a description of best practices and recommendations for the organization of collaborative team-based project implementation. The tool will be designed in such a way as to be easily adapted to a wide range of research projects on any type of textual corpus, regardless of its language or genre. The TInTraMac research tool will be freely downloadable and non-profit, but aims to save significant time and resources for researchers and research projects focusing on large-scale textual corpora, based on handwritten sources from manuscript cultures, promoting groundbreaking research by clearly demonstrating the benefits of employing such advanced digital methods in their fields. At the same time it aims to lower the threshold of adoption by making the TInTraMac research tool freely available, and it aims to flatten th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Recomb 2003' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The Seventh Annual international Conference on Computational Molecular Biology - RECOMB 2003" brings together researchers and students working in the area of bioinformatics or computational biology. As its name indicates, this is the seventh in a series of annual, international conferences. The program is made up of invited talks, participant contributions, and posters. The invited talks present major new developments in computational biology as well as important advances in experimental biology. Contributed presentations are selected on a competitive basis from a large number of submitted papers. Posters give participants a chance to present and discuss their results."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Tolerance mechanisms and germinal center reactions in autoimmunity of rheumatoid inflammation'.

assistant: **Objectives**

Rheumatoid arthritis (RA) is a serious chronic disease affecting a large number of patients and only symptomatic therapies are currently available. The majority of RA patients have elevated plasma levels of the rheumatoid factor (RF) autoantibodies directed to the Fc fragment of IgG. Prof. J. Natvig and coworkers have recently detected distinct Iymphoid structures in RA synovial tissues which have very close immunohistological characteristics to secondary follicles such as the presence of rnantle zone and germinal centers (GC) seen in secondary Iymphoid organs. The GC micro environments are intimately associated with clonal expansion and selection of B cells, sornatic hypermutation in B cell Ig V-region genes and induction of differentiation to memory B cells undergoing isotype switching and somatic mutations. The presence of such 'ectopic' Iymphoid tissue could be of crucial importance in the generation of auto-immune reactions. We intend to investigate whether the immune processes in GC from RA synovial tissues differ from those seen in normal, healthy Iymphoid tissue. We want study the germinal center formation and specially focus on the B and T Iymphocyte interactions and Follicular Dendritic Cells. FDC are a non lymphoid cells closely associated with B cells and encountered only in primary and secondary follicles. We want determine the relationship between these cells and B cells such as adhesion molecule expression and cytokine production. We want also study the features of GC T cells from RA synovial tissues (proportion. phenotype, CD57+, CD40L expression, etc). We want finally determine the degree of mutation and clonality in B-lymphocytes from GC identified in rheumatoid synovial tissues and studv how somatic mutations correlate with phenotypically separated B
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multiferroic nanostructures: a non-aqueous sol-gel approach', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Ferroelectric ferro/ferri-magnetic multiferroic materials are interesting materials not only because they have the properties of their parent materials, but especially because interaction between those polarizations can take place (e.g. magnetoelectric effect). Up to now, those materials are synthesized only by ultra high vacuum (UHV) deposition techniques (i.e. pulsed laser deposition PLD)In this work we are going to use non-aqueous sol-gel approaches to synthesize multiferroic materials by following parallel concepts:- Synthesis of core-shell particles by the benzyl alcohol route.- Synthesis of thin film heterostructures by new atomic layer deposition (ALD) assisted by non-aqueous sol-gel reactions.- Combining the benzyl alcohol route (formation of ferrimagnetic particles) and the ALD (coating of the particle with ferro/piezo-electric material) deposition in order to produce multiferroelectric heterostructures.Once synthesized, these materials will be characterized and the ferroelectric, ferromagnetic properties and the magnetoelectric effect intensively studied.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bluetooth Low-energy Integrated Module for SME’s' (BLIM4SME).

assistant: **Concept**

The demand for wireless sensors in healthcare and lifestyle areas is experiencing rapid growth. Such applications call for radio links which have to fulfil several stringent requirements, such as: standardized connectivity for plug-and-play interconnection with other devices; ultra-portability with tiny modules for maximal comfort for the wearer; ultra-low-power consumption for long autonomy; and flexibility for being easily embedded with a heterogeneous set of other components like sensors, signal processors, energy harvesters.The BLIM4SME project addresses these challenges by developing an ultra-low-power Bluetooth Low Energy (BLE or Bluetooth Smart) module focussing on healthcare and lifestyle. BLE is currently addressed by large semiconductor industries, in the form of complex systems-on-chip (SoC) which aim at covering many applicative areas, but their excessive versatility makes them non-optimal for those applications where ultra-portability and ultra-low-power are mandatory. Therefore, BLIM4SME aims at developing an optimized solution targeting the rapidly increasing landscape of EU SME’s and industries that require beyond state-of-the-art, highly integrated and ultra-low-power BLE radios for their next generation bio-medical, healthcare, sports and fitness products.Concretely, the project will develop RF IP blocks which will be embedded into a single “antenna-and-radio” miniaturized chip leveraging an innovative “integrated passive devices” (IPD) technology platform. The outcome will be a BLE module yielding a factor of at least 5 times better “power-size” figure of merit compared to today’s leading industrial solutions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Disentangling and Preventing  Economic Violence against Women', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Violence against women is a violation of fundamental human rights and substantially compromises womens health, wellbeing, and empowerment. Globally, more than one in four women experience physical and/or sexual violence by a partner in their lives. This risk is considerably higher among women in low- and middle-income countries and in cultures with pronounced patriarchal gender norms. However, existing research has so far neglected an important dimension of intimate partner violence (IPV): economic abuse. This form of abuse includes denying women the right to participate in financial decisions, taking away their income or preventing them from seeking employment. The consequences are profound  economic IPV compromises womens economic welfare and independence, traps them in abusive relationships, and adversely affects their mental health. To tackle this major global health concern, ECOVI has three objectives: first, to establish the prevalence of different forms of economic IPV; second, to develop a theory of economic abuse by investigating drivers of economic IPV and linkages with other forms of IPV; and third, to design and test a community-based prevention approach. To this end, I will focus on India, which is home to 670 million women and girls and exhibits high levels of gender discrimination that exacerbate womens vulnerability to economic IPV. I will capitalise on a mixed-methods approach, including (i) systematic reviews and meta-analyses, (ii) conducting qualitative in-depth interviews and focus groups, and (iii) implementing a cluster randomised controlled trial and innovative survey experiments with husbands and wives in 150 Indian communities. ECOVI will generate the largest existing database on economic IPV and establish an evidence-informed prevention approa