RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enhancing cytotoxic T-lymphocyte tumour-fighting capacity through the modulation of metabolic pathways regulated by ZFP36/ZFP36L1 RNA-binding proteins' (EnhancemenT) targeting Horizon 2020.

assistant: **Abstract**

Cytotoxic CD8+ T-lymphocytes (CTLs) recognize and kill infected and malignant cells. Although CTLs recognize tumour-specific antigens, they often fail to limit cancer growth, as the cancer micro-environment rapidly suppresses their functionality. Therefore, there is the need to unveil new molecular circuits controlling CTL activation, the process through which T-cells proliferate and differentiate into an antigen-specific subpopulation with effector functions. In this way it will be possible to enhance CTL tumour-fighting capacity and improve the efficacy of immunotherapies, especially against solid cancers. My project will focus on how post-transcriptional regulation of metabolism modulates CTL activation. Post-transcriptional responses are fast and important for adaptation to rapidly changing environments. RNA-binding proteins (RBPs) are fundamental modulators of post-transcriptional regulation of many cellular processes, but less is known about how they regulate metabolism. By combining multi-omics approaches (i.e. proteomics, transcriptomics, metabolomics and in-vivo experiments) I will investigate how metabolic pathways in CTLs are modulated by specific RBPs. I will study how these RBPs regulate the stability and the translation of mRNAs encoding metabolic enzymes. Finally, I will control the expression of these RBPs in CAR-T cells (engineered T-lymphocytes used in cancer immunotherapies) to regulate metabolic pathways and enhance the in-vivo solid tumour-fighting capacity of these cells. Thus, my research will lay the groundwork for the identification of new methods to stimulate metabolism of tumour-infiltrating CTLs to enhance their functionality. My expertise in RNA-biology will complement the new skills I will learn from my host lab and collaborators, combining
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Gromov-Witten Theory: Mirror Symmetry, Modular Forms, and Integrable Systems' (GWT) under Seventh Framework.

assistant: **Objectives**

The Gromov-Witten invariants of a space X record the number of curves in X of a given genus and degree which meet a given collection of cycles in X. They have important applications in algebraic geometry, symplectic geometry, and theoretical physics. The program proposed here will allow us to compute Gromov-Witten invariants, and particularly higher-genus Gromov-Witten invariants, for a very broad class of spaces. Recent progress, partly due to the Principal Investigator, has led to a greatly-improved mathematical understanding of the string-theoretic duality known as Mirror Symmetry. This allows us to compute genus-zero Gromov-Witten invariants (those where the curves involved are spheres) for a wide range of target spaces. But at the moment there are very few effective tools for computing higher-genus Gromov-Witten invariants (those where the curves involved are tori, or n-holed tori for n>1). We will solve this problem by extending mathematical Mirror Symmetry to cover this case. In doing so we will draw on and make rigorous recent insights from topological string theory. These insights have revealed close and surprising connections between Gromov-Witten theory, modular forms, and the theory of integrable systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Partner Network for a Clinically Validated Multi-Analyte Lab-on-a-Chip Platform' (PARCIVAL), addressing dissemination and exploitation.

assistant: **Impact**

The objective of PARCIVAL is to develop an integrated and automated multi-analyte lab-on-a-disk platform for the fast and reliable sample in -> answer out diagnosis of highly infectious respiratory pathogens, resistance patterns and biomarkers for individual severity of the infection. The platform format will be based on completely integrated microfluidic foil-disposables. The disposables will feature different panels (selection of pathogens, resistance patterns, biomarkers), which can be freely selected and combined to allow a comprehensive choice of diagnostic parameters by the clinician at the point-of-care, vastly increasing the access to diagnostic information for doctors in everyday situations and emergencies. The integrated platform with pre-packaged liquid and dry reagents will automate all processing steps from sample preparation, over assay processing up to result reporting.This will allow evidence-based therapeutic decisions, allow antibiotic prescriptions which are tailored to the individual patient and thus offer the prospect to greatly improve therapeutic outcomes. Also, an air-sampling add-on module for monitoring of clinical ventilation systems will be developed and interfaced to the platform. By acting as early warning system that is able to identify airborne pathogens including resistances, this will increase the impact towards the topic 2.3.1-4 (“retard the development of multi-drug resistance”) as well as the area 2.3.1 (“development of effective infection prevention and control strategies”).The consortium consists of 9 partners (6 enterprises (4 SMEs), 3 institutes). The project is heavily based on the research capabilities of innovative SMEs. Therefore, SMEs will be the main beneficiaries of exploitation in the project. The key-developments of invo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Optical Metamaterials by Polymer Self-assembly' to be submitted under Horizon 2020.

assistant: **Abstract**

Metamaterials are artificially structured materials whose interaction with electromagnetic waves is determined by their structure rather than by their chemical composition. The resulting material properties are not found in nature. Metamaterials that operate at optical frequencies, known as optical metamaterials, have attracted special attention due to their potentially ground-breaking technical applications such as sub-diffraction imaging or invisibility cloaking. The creation of optical metamaterials remains technologically challenging, as it requires fabricating nanometre scale features over macroscopic areas. Top-down lithographic techniques were utilized to create infrared metamaterials, and negative refraction was found in parts of the visible spectrum. However, state-of-the-art lithography is limited by the accessible feature sizes and often results in only microscopic patterning areas. Furthermore, these optical metamaterials aren’t truly three-dimensional (3D) as they are limited to a narrow range of light propagation directions.  This research project will investigate an alternative bottom-up approach toward the fabrication of 3D optical metamaterials by replicating continuous network structures of self-assembled block copolymers. The ultimate goal is to realize a material that exhibits a negative refractive index in the visible optical spectrum. Advanced in situ scattering techniques will be used to investigate the self-assembly of 3D network structures by means of well-controlled annealing experiments. This will provide important insights that will help to overcome the limitations of “self-assembled” optical metamaterials made by current empirical approaches. The significance of this research stems from the intended fundamental understanding of self-assemble
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Colonial Recipes, Then and Now'.

assistant: **Objectives**

CORE (Colonial Recipes, Then and Now) investigates how domestic colonial food cultures in the Portuguese empire (1450-1600) reflect the mobility, agency, labour, and knowledge of women and enslaved cooks; and how colonial recipes can create space for more nuanced conversations around colonial heritage. The project takes a global history approach to the empire, examining the extent to which the mobility of people, foods, labour, and knowledge between key port cities shaped colonial food cultures. By focusing on domestic spaces, it places women and enslaved cooks, who did the labour of food preparation, centre stage. In this way, the project revalorises domestic spaces as sites of global exchange, which have been largely excluded from studies of global history, as well as insisting on the importance of gender to understand the complexities of the relations between mobility, food, and empire. By spotlighting colonial recipes, CORE will spark new scholarly conversations about the insights these texts offer into: subaltern mobility, creativity, and adaptability; the intersecting production of gender, race, and class; and colonial households as the centre of social provisioning and wider infrastructures of empire, examining how new colonial cuisines intersect with colonial regimes of trade, agricultural production, and domestic slavery. It makes three historiographical interventions, namely it: (1) responds to calls to write a global history of the early modern Portuguese empire; (2) brings the new imperial history further into dialogue with a history of the Portuguese empire by showing how food illuminates colonial politics, especially negotiations around gender, race, and class; and (3) contributes to public debate around the production of heritage about the colonial past,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'GPU-Assisted Massive Volume Data Visualisation'.

assistant: **Innovation**

High-resolution medical volume data (containing billions of voxels) is used in many clinical applications. However, interactive visualisation of gigabyte-sized volumes on a desktop PC is challenging, due to the heavy computation and the memory consumption. In recent years, the graphics processing unit (GPU) has evolved at an increasing pace, and tremendous improvements have been achieved in its capabilities. GPU performance now substantially exceeds that of CPUs in both the raw computational power provided and its speed of development. Thus, the GPU is now the ideal platform for efficient visualisation for large volume data. However, current methods for rendering large volume datasets are limited, either in performance, accuracy, flexibility or scalability. This project addresses this by presenting techniques to perform volume visualisation of large datasets on off-the-shelf hardware by harnessing the power of GPUs to provide high performance and produce high-quality images. We will achieve this by implementing a multi-resolution framework with two parts: data management on the CPU and real-time rendering on the GPU. We propose a new rendering pipeline by directly treating each volume brick as a single GPU rendering primitive, and efficient cache management to avoid cache thrashing of GPU memory. Forward mapping will allow arbitrariiy many primitives to be rendered on the GPU in a stream-like manner, making our system fully scalable to an arbitrarily large dataset. Further acceleration will be achieved by using a coarsely-fitted proxy geometry, and advanced illumination techniques will be introduced for better quality visualisation at high frame rates. We will also extend our applications from a single GPU to multiple GPUs. The resulting system will allow domain scienti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Personalised Learning & Collaborative Working Environments Fostering Social Creativity and Innovations Inside the Organisations' (ARISTOTELE) under Seventh Framework.

assistant: **Objectives**

ARISTOTELE will enhance learning and training of the workers within their organisations defining and developing models, methodologies, technologies and tools to support the emergence of competences and creativity by self-organizing acquisition, processing and sharing of new information and knowledge with peers.To achieve this ARISTOTELE will design and develop a prototype platform presenting, as key differentiators, capabilities to support: i) creation and execution of personalised learning activities supporting an hybrid (adaptive and non-adaptive) strategy, ii) innovation building and management processes and iii) collaborative knowledge exploitation and acquisition during the daily worker activities. Human factors such as motivation to collaborate and share knowledge and innovative ideas within organisations will be considered and addressed in the designing and developing of the ARISTOTELE platform, including adoption inside organisations.The core of the solution starts from an already existing platform for the on-demand creation of personalised and adaptive Learning Experiences, based on suitable domains, learner models and didactical strategies, that will be extended in terms of models, methodology and functionalities towards the organisation, together with the integration, cooperation and covering of other related organisational issues like Knowledge Management, Human Resource Management and innovation management.Several challenging and interdisciplinary research themes are concerned with the project such as didactic modelling, collaborative innovation and working environments, knowledge management and discovery, collective intelligence, adaptive and non adaptive learning strategies.The project enables substantial improvements with respect to the state-of-the-art
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Urban logistics and plaNning: AntiCipating urban freigHt generAtion and demand including dIgitalisation of urbaN freight' (UNCHAIN) under Horizon Europe.

assistant: **Objectives**

UNCHAIN will “break the chains”, boosting the cooperation between public authorities and logistics stakeholders. It will create a set of services for optimal and flexible urban logistics operation, management, planning and policymaking, unleashing the potential that technology and digitalisation can bring to the sustainable urban logistics and moving towards climate-neutral and smart cities. UNCHAIN will implement a standardised and reliable data exchange ecosystem supported by a public-private collaborative framework that will allow the establishment of reliable data sharing agreements, break data silos and make the urban freight data more available and accessible. Driven by the unlocked data, an innovative set of 12 urban logistics services will be implemented to optimise the allocation of urban space, improve the policy-making capacity of local authorities and optimise network management and logistics operation. With UNCHAIN, public authorities will improve their data collection capabilities and have the right tools to achieve sustainability goals. Meanwhile, for operators, having services aligned with their own and society's objectives will unlock mutually beneficial cooperation schemes, a key factor for long-term collaboration and the establishment of sustainable urban freight transport policies and operations. 10 European cities will participate in UNCHAIN activities: Madrid, Berlin and Florence as living labs; Prague, Mechelen, Madeira and Riga as follower cities, and Brest metropole, Ravenna and Alba Iulia as peer- cities supporting the early adoption of the results. Also, the well-balanced representation of the urban logistics industry, with DHL and UPS, will ensure large-scale impact and feasibility of the project results.


**Keywords:** urban logistics, sust
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Magnetogenesis from Axion-SU(2) Inflation and applications to Gravitational Waves' (MASUGRAV).

assistant: **Concept**

Magnetic fields are ubiquitous in our Universe. The question of their origin and subsequent evolution is a challenge for moderncosmology. Recent bounds on magnetic fields from blazar observations, together with the requirement for initial “seed” field for dynamo and compression amplification mechanisms motivate the study of possible primordial origins of magnetic fields. This project combines expertise in early universe physics with an expertise in astrophysics, magnetohydrodynamics and advanced numerical tools to study the production of magnetic fields in models of axion inflation coupled to the Standard Model of particle physics - so-called axion-SU(2) inflation. The results of this project will trace the origin of magnetic fields from the early to the present-day universe and confront the axion-SU(2) magnetogenesis by cross-correlating cosmic microwave background and blazar observations. To achieve this I will go beyond the current understanding of the simpler so-called axion-U(1) magnetogenesis models widely studied until now, and study the viability of chiral magnetic field production in the axion-SU(2) case. Furthermore, I will develop new numerical tools to determine how the presence of feedback mechanisms affect magnetogenesis. I will also compute the spectrum of gravitational waves generated by axion-SU(2) models in the radiation-dominated era of the early universe, and compare it to other known sources of gravitational waves such as cosmic strings to understand potential differences in the observational predictions. My experience in early universe physics together with the present world-leading expertise in magnetohydrodynamics at Nordita make it an ideal place for a two-way transfer of knowledge essential for the implementation of this project. This project a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Asymptotics of Operator Semigroups' (AOS), addressing dissemination and exploitation.

assistant: **Impact**

The theory of asymptotic behaviour of operator semigroups is a comparatively new field serving as a common denominator for many other areasof mathematics, such as for instance the theory of partial differential equations, complex analysis, harmonic analysis and topology.The primary interest in the study of asymptotic properties of strongly continuous operator semi-groups comes from the fact that such semigroupssolve abstract Cauchy problems which are often models for various phenomena arising in natural sciences, engineering and economics.Knowledge of the asymptotics of semigroups allows one to determine the character of long-time evolution of these phenomena.Despite an obvious importance, the asymptotic theory of one-parameter strongly continuous operator semigroups was for a very long time acollection of scattered facts rather than an organized area of research. The interest increased in the 1980s and the theory has witnessed adramatic development over the past thirty years.Still there is a number of notorious open problems that have been left open. These missing blocks prevent the theory from being complete, slowdown the development of the theory and discourage specialists from related fields to engage into the theory.The goal of the project is to give new impetus to the theory of asymptotic behavior of operator semigroups. To this aim we plan to extend andunify various aspects of the asymptotic theory of operator semigroups: stability, hyperbolicity, rigidity, boundedness, relations to Fredholmproperty, to work out new methods and to solve several long-standing open problems thus giving the theory its final shape.We intend to create an international forum that enables and promotes a multi- and cross- disciplinary exchange of ideas, methods and tools under the common