RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Scientific training Programme for Advanced Research and Knowledge in Light-Matter Engineering' (SPARKLE) targeting Horizon Europe.

assistant: **Abstract**

SPARKLE will build a mixed experimental and theoretical network to develop the necessary tools and techniques to exploit light-matter coupling to manipulate materials functionalities. SPARKLE will bridge the gap between photonics on the one hand and materials science on the other, by advancing the understanding of light-matter interaction via two distinct yet complementary approaches: (i) the utilization of tailored laser fields and (ii) the confinement of light in optical environments, called cavities. The network will connect leading academic and industrial experts, to push the development of novel detection techniques, innovative light sources, state-of-the-art ab-initio simulation methods and innovative designs of light-matter hybrid solid-state systems for devices at the interface of photonics, electronics and quantum technology. We are convinced that this topic is mature enough to provide Europe with a first generation of 14 early stage career scientists trained on interdisciplinary and intersectoral aspects of light and matter based technology, while at the same time pushing forward a cutting edge research field, the one of polaritonics. SPARKLE, will follow the guiding principle of ""model - simulate - design - measure"", providing the doctoral candidates with a unique multidisciplinary training which will place them at the forefront of the research on light-matter hybrid systems. They will collectively engage in a scientific endeavour, the control and manipulation of the quantum nature of material and light, that bridges the domains of theoretical solid state physics, quantum optics, ab initio material simulations, photonic engineering, laser physics and ultrafast spectroscopies. Last but not least the doctoral candidates will be equipped with the required entr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Microeconometrics of Consumer and Labour Supply Behaviour' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The aim of this research programme is to significantly enhance our knowledge of consumer and labour supply behaviour using frontier microeconometric analysis.  The objective is to improve our understanding of how individuals make choices, how they react to changes in the economic environment and how they respond to policy reforms. There are two key aspects to the proposed research. The first is to extend the analysis of consumer behaviour and revealed preference to allow for preference heterogeneity, many goods and taste change. A central part of this work will concern the imposition of shape restrictions that derive from revealed preference and integrability restrictions in the nonparametric analysis of consumer behaviour.  This work will focus on the microeconometric analysis of consumer surveys and the nonparametric estimation of consumer demand at the household level. The second is a parallel set of studies that will examine the life-cycle behaviour of consumption and labour supply choices in a dynamic environment with uncertainty. This work will use panel data to investigate non-separabilities between consumption and labour supply. It will explore the role of family labour supply as a mechanism to ‘insure’ families against adverse economic shocks. It will involve bringing models of family earnings dynamics together with consumption decisions.  The focus will be on the importance of non-separabilities, dynamics and heterogeneity in understanding the behavioural responses of consumption and family labour supply behaviour to policy reforms and other changes in the economic environment. Through a sequence of interrelated studies in these two broad areas, the research programme aims to radically move forward methodological approaches in empirical economics to modelling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of Armored targeted CAR-T cells for immune reset of T cell-mediated autoimmune diseases' (2021-2027).

assistant: **Concept**

Autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS) result in chronic pain, disability, and major socioeconomic burden, with estimated 20.9 million RA patients globally. Despite significant therapeutic advances, up to 20% of RA cases remain refractory, and MS frequently progresses despite treatment. Current therapies rely on systemic immunosuppression, require chronic dosing, and inadequately target tissue-resident pathogenic immune cells - resulting in persistent inflammation, progressive organ damage, and heightened infection risk. Our breakthrough solution is an inducible CAR T cell platform for Unleashing Suppression of inflammation (iCARUS). Unlike current CAR T therapies that indiscriminately deplete entire immune lineages, our approach combines selective depletion of pathogenic T cells with programmable local delivery of anti-inflammatory cytokines or cytokine blockers. This dual-action design enables targeted reset of pathological immune circuits, reprogramming of local tissue microenvironments, and durable disease remission without systemic immunosuppression. For patients, this platform promises a game changer in quality of life and lower infection risk. For payers, it provides a potentially curative, one-time treatment reducing lifelong healthcare costs.In this PoC, we will advance our ground-breaking technology from constitutive to inducible targeted CAR and cargo designs, guided by single-cell multiomics and advanced artificial intelligence. We will validate efficacy and safety in RA and MS murine models, paving the way for IND-enabling studies. This modular platform can be expanded to other autoimmune, neuroinflammatory, and fibrotic diseases, representing a new paradigm of precision immunotherapy where both the CAR and its the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards evidence-based genomic medicine: filling the evidence gaps through modelling studies' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

At increasingly high rate, genome-wide association and whole genome sequencing studies unravel genetic variants implicated in common diseases such as coronary heart disease, cancer, dementia and type 2 diabetes. One of the major promises is that these advances will lead to more personalized medicine, in which preventive and therapeutic interventions are targeted to individuals based on their genetic profiles.There is increasing interest in the early adoption of novel applications and many commercial applications are already marketed without supporting empirical evidence. Already now, regulatory agencies like the US Food and Drug Administration face substantial gaps in empirical evidence, which hamper proper recommendations. The increasing interest in genomic medicine, the evidence gaps and the scarcity of research budgets are strong incentives to search for novel strategies that make the process of translation research more efficient and effective.This project aims to investigate modelling approaches that can be used to predict the expected outcomes of empirical studies on the basis of published epidemiological and intervention studies. This approach can be used to 1) identify genomic applications that are promising and warrant further empirical research, and 2) fill in evidence gaps by identifying applications that are not expected to improve health or health care. When they are valid, precise and simple, modelling studies can optimize the process of translational research so that time and money are allocated to the most promising applications.In this project, I will 1) characterize empirical studies in translational research in terms of the main outcome measures used and their key determinants; 2) develop simulation models that predict outcome measures; 3) investigate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Manual Operation for 4th Generation Airliners', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The project will identify current deficiencies of situational awareness and manual control of modern flight decks, and impact the design of procedures, training and cockpit design in the aerospace industry. Procedures will be developed to help the pilot identify not only the fault, but where the airplane is with respect to its operational envelope and limits. By empowering the pilot to utilize his/her skills more effectively, identifying how to create conditions that increase the likelihood of success, and developing guidelines to train fundamental skills to deal with unexpected events, Man4Gen will directly impact the reduction of fatal accidents such as those caused by LOC-I.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'PAtient Specific Simulation and PreOperative Realistic Training for liver surgery'.

assistant: **Innovation**

In 2006, over 45.000 European citizens died of cirrhosis of the liver and 44,000 additional citizens of liver cancer, knowing that the same year 48,700 new liver cancer cases were declared. Surgical procedures remain the options that offer the foremost success rate against such pathologies. Regretfully, surgery is not so frequent due to several limitations. Indeed, eligibility for liver surgery is based on the minimum safety liver volume remaining after resection (standardized FLR), but this minimum value varies over time and from one patient to another according to biological and mechanical properties of the liver. Since 1996, a large set of preoperative planning softwares has been developed, but all of them provide only the volume of the liver before and after resection. However interesting, this limited information is not sufficient to improve the rate of surgical eligibility. PASSPORT for Liver Surgery aims at overcoming these limitations by offering a patient-specific modelling that combines anatomical, mechanical, appearance and biological preoperative modelled information in a unified model of the patient. This first complete Virtual liver" will be developed in an Open Source Framework allowing vertical integration of biomedical data, from macroscopic to microscopic patient information. From these models, a dynamic liver modelling will provide the patient-specific minimum safety standardized FLR in an educative and preoperative planning simulator allowing to predict the feasibility of the gesture and surgeons' ability to realise it. Thus, any patient will be able to know the risk level of a proposed therapy. Finally, we expect to increase the rate of surgical treatment so as to save patients with a liver pathology. To reach these purposes, PASSPORT is composed of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Disordered Ultra-Cold Atoms' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

One of the main unsolved problems in condensed matter physics is quantum transport in the presence of disorder and strong interactions. Theoretical and experimental progress has been slow due to the intrinsic difficulties to control all relevant variables. Recent progress in the field of ultra-cold atomic gases, with Europe playing a leading role, paves the way towards highly controlled investigations of this many-body physics. Our proposal is to bring a young researcher experienced in cold atom physics to Rome to work within a condensed matter theory group which has played a leading role in the development of the theory of interacting and disordered electron systems. The objective is the transfer of knowledge between condensed matter and cold atom physics which could significantly advance both fields. A key aspect of the proposal is a close collaboration with leading experimental groups working on ultra-cold atoms.The researcher, who has contributed to the subject but in the non-interacting regime, will address the interacting ultra-cold atom problem by reformulating the theories for disordered electrons thehost has developed. This will include a reformulation of the scaling theory of disordered electron systems, the study of the interplay between quantum chaos and interactions and the investigation of dirty superconductors. This theoretical work will aim at making realistic predictions for ultra-cold atom experiments. It will be complemented by state-of-the-art numerical simulations. The project will dramatically increase the researcher's competences in the challenging field of strongly correlated systems and it will add an international dimension to his career, thus allowing him to reach a position of professional maturity. The project will also contribute to assure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Nature Based Smart Water Grids for Integrated water and drought management' (WATERGRID).

assistant: **Concept**

WATERGRID’s objective is to develop and demonstrate the Smart Water Grid (SWG) concept for more climate resilient water management, particularly targeting extreme drought, but framed within Integrated Catchment Management, addressing the whole catchment in a holistic approach. The resource efficiency of Nature Based Solutions (NBS) previously established in eight sites will be analysed alongside the academic literature, forming an Evidence portfolio (Project Result 1 - PR1). Of these eight sites, five will be demonstrators, spread across the Atlantic, Continental, Mountain and Mediterranean biogeographical areas, with specific water scarcity challenges, NBS types and scales, in which 58 additional innovative and locally attuned NBS will be implemented to slow, move and actively store water for reuse as part of locally designed SWGs. Three validation sites will mainstream potential of the SWG approach and demonstrate replicability of the Project Results (PRs) that have been co-created and co-deployed with 138 stakeholders in a participatory approach. Protocols and standards will be developed, providing a step-by-step guide for the design, maintenance and operation of the SWG (PR2). A digital Platform (PR3) will display models of the catchment and a Design App will provide guidance to users on designing NBS into their SWGs. This Platform will be linked to a Monitoring programme (PR4) to display real time information via a Digital Twin to support long term maintenance of SWGs. An Operationalising toolkit (PR5) will create enabling social, governance and economic environments for sustainable SWGs. Finally, at least three Policy briefs (PR6) will display SWG benefits to various policies, from the EU to the local scale. By 2035, WATERGRID expects to increase by 20% the water
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unraveling the role of Alu RNAs accumulation in cancer progression' under Seventh Framework.

assistant: **Concept**

Background and rationale: The Alu repeat elements are the most abundant short interspersed repeated elements (SINEs) in human genome. Recently, the accumulation of Alu RNA transcripts, following DICER1 deficit, has been shown to be responsible for a human disease, the dry form of age-related macular degeneration (AMD), Geographic Atrophy (GA). Interestingly, increased levels of Alu RNAs and reduced DICER1 expression have been observed in several cancers, although no correlation has yet been established.The main objective of the present proposal is to determine the potential role of Alu RNAs accumulation in tumor formation and progression.Specific aims: The project will focus on three aims: 1) the analysis of Alu RNA expression in cancer; 2) the study of Alu RNAs-mediated signal in cancer; and 3) the analysis of the inhibition of Alu RNAs accumulation in vivo.Methods: A panel of cancer cell lines and human tumors will be used for qRT-PCR, northern blot, western blot, immunohistochemical analyses and hypoxic studies, in order to determine the expression profile of Alu RNAs and its relation with DICER1 expression in cancer. To study Alu-mediated signaling, the potential involvement of inflammasome and ERK1/2 activation in human tumors and in the cancer cell lines, which express high Alu RNAs levels, will be assessed, carrying out western blot, qRT-PCR, ELISA assays and immunohistochemical analyses. The effect of Alu RNA accumulation on cell fate will be assessed, by performing proliferation, migration and tumorigenesis assays. Stable clones, in which Alu RNAs expression is inhibited, will be generated to study whether inhibition of Alu RNAs accumulation affects tumor growth and metastasis dissemination.Expected outcome: Overall, these findings will provide new insights int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'UAV ENGINEER FOR OPTIMISATION OF FIREFIGHTING DRONE STABILISATION' under Horizon 2020.

assistant: **Concept**

DRONE HOPPER is a technological start-up founded in 2015 and devoted to the design, production and operation of drones or Unmanned Air Vehicles (UAV) for firefighting. Drones have the potential to overcome the limitations of helicopters and hydroplanes in firefighting, as no lives would be put at risks even during night operations and offering the possibility to fly at low altitudes to improve effectiveness. However, nowadays the use of drones in fires is limited to monitoring, surveillance and data collection tasks because current drone technologies based on electrical systems lack the necessary power to lift heavy loads. DRONE HOPPER has developed and validated heavy duty commercial drones, designed for transport of heavy loads (high water volumes) and with a patented system for spraying liquids increasing the effective coverage area of the intervention.  This technology enables that our drones have an  excellent potential to disrupt the market for unmanned firefighting. Nevertheless, we need to evolve the attitude control and stabilisation system to reach the required robustness and reliability of operations.This project is aimed to fill a job vacancy for an UAV engineer to join our R&D team as an Innovation Associate, with an extendable 1-year duration contract and reporting directly to our CTO. The profile of the Associate is a PhD researcher with experience in the development of flight control systems for rotatory wing UAVs, either helicopters or multi-rotors. The Associate will assume a leading role in the development, implementation and testing of an enhanced stabilisation control system for our drone platform, with the overall objective of contributing to increase the UAV´s payload capacity from current 150L to 600L.