RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Disseminating Innovative Solutions for Antibiotic Resistance Management' (DISARM).

assistant: **Innovation**

The DISARM thematic network (Disseminating Innovative Solutions for Antibiotic Resistance Management) is focused on disseminating best practices from innovative farms and research on how to reduce antibiotic resistance in livestock farming.  Antibiotic resistance management is not only important to farming, it can also lead to reduced effectiveness of antibiotics in treating humans.  Tackling antibiotic resistance is a major strategic challenge for European livestock farmers, an industry worth over 145billion euros.  Evidence shows that rates of antibiotic use and resistance vary greatly from farm to farm and, that with the adoption of appropriate innovative on farm management practices that both the use of antibiotics and the development of resistance can be reduced.  Disseminating these effective management practices is at the heart of the DISARM project, which will work with farmers, vets, advisors, industry and researchers to identify and disseminate widely the most cost effective and beneficial strategies.  This will be delivered by:* Developing a 600 member multi-actor Community of Practice to share, debate and disseminate the most promising strategies to reduce antibiotic resistance in livestock farming;* Producing 10 best practice guides, supported by 100 best practice abstracts and 100 short videos to explain how farms have successfully adopted innovative practices to reduce antibiotic resistance;* Working with 40 farms (in 8 countries) to develop multi-actor farm health plans with at least 30 of these being used as case studies to show other farms how working with their vet, feed or equipment suppliers and advisory services can help them adopt a set of best practices suited to their farm;* Run 80 events to disseminate best practices, hosted by farmers or resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovative integrative tools and platforms to be prepared for radiological emergencies and post-accident response in Europe' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This proposal aims to close gaps that have been identified in nuclear and radiological preparedness following the first evaluation of the Fukushima disaster. It addresses the call Fission-2010-3.3.1: Update of emergency management and rehabilitation strategies and expertise in Europe. The consortium intends to review existing operational procedures in dealing with long lasting releases, address the cross border problematic in monitoring and safety of goods and will further develop still missing functionalities in decision support system ranging from improved source term estimation and dispersion modelling to the inclusion of hydrological pathways for European water bodies. As the management of the Fukushima event in Europe was far from being optimal, we propose to develop means on a scientific and operational basis to improve information collection, information exchange and the evaluation for such types of accidents. This will be achieved through a collaboration of industry, research and governmental organisations in Europe taking into account the networking activities carried out under the NERIS-TP project. Furthermore, the NERIS Platform member organisations (so far 43 partners) will be actively involved in the development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Active Site Repurposing – computational design of new enzyme functionalities by emulating nature' in the context of a Seventh Framework call.

assistant: **Objectives**

Computational enzyme design challanges our understanding of molecular enzymology and recognition and has previously been used to generate functional biocatalysts for a hand full of reactions. However, thus far all computationally designed enzymes showed low catalytic efficiency when compared to naturally occurring ones. Evolutionary, new enzyme functions are introduced into nature by amino acid sequence optimization. This is facilitated via repurposing the catalytic machinery of an existing active site from an enzyme with a specific function, for a new/different reaction. Here I propose the utilization of already characterized catalytic geometries derived from natural enzymes for computational enzyme design. Using these machineries for the design of non-natural reactions, I want to redesign mono- and dinuclear metalloenzymes for the catalysis of a nucleophilic aromatic substitution reaction. In particular, we want to design an enzyme that catalyzes the dechlorination of the herbicidal compound atrazine, which was shown to accumulate in soil and ground water and was correlated to increased risk of cancer. The project will involve the construction of a structural database exclusively comprising scaffolds of mononuclear zinc enzymes. The rmaining stages will include calculation and construction of a substrate model, which recapitulates the transition state of the reaction, the actual design calculations as well as computational and rational evaluations thereof. Subsequently, the best designs as judged from calculated energy and chemical intuition, will be experimentally tested. Two already established assays to test for atrazine dechlorination activity are available and will be used to complete this task. If necessary, directed evolution methods will be used to enhance the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Regulation and relevance of circadian leukocyte dynamics for skin immune homeostasis' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The skin is the largest organ of the body and represents the primary physical barrier to the environment. Circadian, ~24h rhythms in the environment have emerged as important regulators of the immune system, yet, the circadian dynamics of leukocyte turnover and function in the skin are completely unknown. Insights into the mechanisms occurring at this host-environment interface will be of key importance to understand how rhythmicity in the immune system is achieved. This will produce knowledge to optimize adjuvant design and maximize adaptive immune responses such as required in vaccinations, ultimately providing a time window for therapy.We will elucidate how circadian dynamics in leukocyte input and output to the skin interplay to create oscillatory numbers of leukocytes in this tissue. We will assess the impact of lineage-specific rhythmicity and arrhythmicity on skin immune homeostasis using an innovative combination of novel genetic tools. We will mechanistically assess how circadian leukocyte dynamics in the skin are governed at a higher level by the sympathetic nervous system. We will finally unravel the cause and the functional relevance of circadian leukocyte dynamics in the skin by assessing whether they primarily represent a response to exogenous factors or whether they are caused by physiological tissue turnover in response to daily recurring mechanical stress. Based on these data we will create a mathematical model determining circadian skin leukocyte turnover in a quantitative manner.The project combines the disciplines of immunology and chronobiology by obtaining unprecedented insights into circadian immunity in the skin, a critical epithelial barrier site, which is of broad impact for both fields. Our extensive experience in the rhythmic control of both
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Production and verification of the 2nd generation of ac-modules ('PV2GO')' (PV2GO).

assistant: **Innovation**

A new generation of AC modules is designed, prototyped and tested in laboratory and European field conditions. The AC modules are designed for reliable operation during the typical PV module lifetime of twenty years, the cost of production is strongly reduced in comparison to current technology, and the efficiency of the PV module and the inverter allow high-energy yields. Through demonstration of the state-of-the-art technology in European regions with limited experience with this modular PV system concept, a further expansion of the market is envisaged. At the same time it is the opportunity for both the end-user and the utility company to get acquainted with this technology. The feedback on the technical performance and the overall satisfaction of these demo-systems will provide useful input for the design of the 2nd generation technology in power-electronics packaging. Not only the product itself but also the manufacturing process will be the subject of detailed analysis and improvements will be suggested to enable large scale production of the 2nd generation AC-module aiming at a breakthrough in cost of PV systems.The project results relate to a study of interactive advertising on the Internet, interactive TV and mobile communications, the role of interactive advertising in the marketing mix, the aspirations of advertisers, the contribution to brand building and relevance of click-through rates. References made to standards and measurement of advertising effectiveness. Guidelines are provided for the use of interactive advertising.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ensured Randomness Integrity in Device-Independent Networks', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

ERIDIAN will develop a market-ready quantum random number generator for Device Independent (DI) Quantum Cryptography (QKD), which offers the best possible security guarantees.  The prototype developed in ERIDIAN will enable major industrial players to make DI QKD a commercial reality.  Current, classical cryptography is based on the assumed difficulty of certain mathematical problems and thus insecure against future mathematical advances and against quantum computers.  Quantum cryptography gives future-proof security guaranteed by physical laws, but until now is very difficult to commercialise:  the user must trust the communications equipment and its supplier, making a mass-market approach impossible.  The DI approach to quantum cryptography uses strong, directly observable data correlations, technically a ""loophole-free Bell Inequality Violation"" (BIV), to guarantee security.  Because the security (or not) of the connection is transparent to the user, there is no need to trust the communications provider, greatly facilitating commercialisation.  The first loophole-free BIVs were demonstrated in 2015, using laboratory-grade random number generators developed in the ERC starting grant AQUMET.  ERIDIAN will advance to the prototype stage this randomness generation technology, a critical element of the BIV and thus a requirement for the DI approach.  The availability of a commercial-grade randomness source suitable for BIVs will allow industrial actors such as telecommunications providers to enter the DI field and offer solutions to a broad range of customers.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Accelerating Datacentre performance through Memory Chips to efficiently manage the Big Data Age', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Datacentres have become a backbone of the modern economy, they currently consume 2% of worldwide electricity, rising to 10% by 2030. While compute accounts for 40% of this energy, 80% of this compute energy is related to moving data between the main memory chips and the processor (CPU), a structural bottleneck within server design that causes slowdown and low CPU usage. Development of ground-breaking Processing-In-Memory (PIM) technology by UPMEM prevents this data movement by performing calculations in the memory chips, where the data resides. By eliminating the need to move data off chips, PIM bypasses structural bottlenecks. The power of UPMEMs technology comes from leveraging existing industry protocols, chip technology and programing languages, and designing PIM modules that fit into standard memory slots. When compared to those using conventionalmemory, PIM equipped servers have proven to be up to 20x faster, 10x more efficient and cheaper for Big Data and AI applications.


**Keywords:** Memory chips,Processing in memory,Data centres,Big Data,Severs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Spatial Metabolic Regulation in Kidney Repair' (SPARK).

assistant: **Concept**

Chronic kidney disease (CKD) is a global health concern, and the limited treatment options for end-stage kidney disease have remained unchanged for decades. Concurrent insults to the kidney can exacerbate disease progression, but the underlying potential to have kidney repair after such injury remains poorly understood. The tricarboxylic acid (TCA) cycle, a fundamental metabolic pathway, plays a vital role in energy production and biomolecule synthesis. Recent research by my group has revealed that failed repair and subsequent fibrosis in kidney epithelial cells are linked to anaplerotic failure in the TCA cycle, resulting in the inability to maintain sufficient levels of TCA intermediates. These metabolites regulate chromatin remodeling and cell signaling pathways, influencing cell fate decisions. SPARK aims to investigate the impact of perturbed cell metabolism and metabolic crosstalk within kidney microenvironments on cell fate decisions during injury and repair. The project will map the metabolic, proteomic, and transcriptomic interactome at an unprecedented resolution, focusing on the kidney tissue microenvironment. By integrating spatial multi-omics data, exometabolite interactome analysis, and human kidney biopsies, actionable targets will be identified. In vivo studies using reporter mice and ex vivo preserved human kidneys will validate the metabolic effects of the selected targets. This research will provide insights into how the metabolic interactome governs repair through epigenetic modulations in the kidney and establish a paradigm for studying tissue homeostasis in various contexts.


**Keywords:** Kidney disease, Cell metabolism,  Cell fate decision, Spatial metabolomics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Rationality of varieties and algebraic cycles' to be submitted under Horizon 2020.

assistant: **Abstract**

This project uses algebraic cycles and unramified cohomology to attack fundamental questions about the rationality, stable rationality and unirationality of rationally connected varieties, the integral Hodge conjecture for abelian varieties, as well as the Griffiths-Harris conjecture about curves on three-dimensional hypersurfaces. A breakthrough of Voisin, with improvements by Colliot-Thélène--Pirutka and myself, recently led to tremendous advances in our understanding of (stable) rationality of rationally connected varieties. For instance, this allowed me to solve the rationality problem for hypersurfaces under a logarithmic degree bound, improving previous linear bounds of Kollár and Totaro. This project pushes this circle of ideas further, aiming in particular at a solution of the rationality problem beyond my logarithmic bound.One of the most powerful (stable) birational invariants of smooth projective varieties is unramified cohomology. In general, this invariant is notoriously hard to compute and we aim to develop new tools which allow to compute unramified cohomology more efficiently. We will use this to analyse the third unramified cohomology of abelian varieties and of hypersurfaces in projective 4-space. By a result of Colliot-Thélène and Voisin, this will allow us to attack the integral Hodge conjecture for abelian varieties, and hence, by work of Voisin, the longstanding open problem whether cubic threefolds are stably rational, as well as an old conjecture of Griffiths and Harris concerning curves on three-dimensional hypersurfaces.We also introduce a cycle-theoretic approach, using the torsion order of symmetric products, to construct an obstruction for the unirationality of rationally connected varieties. We aim to use this to show that not every rationa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Conservation genomics of endangered indigenous European horse breeds'.

assistant: **Innovation**

The European continent encompasses about half the total number of horse breeds on the planet. According to the Food and Agriculture Organization of the United Nations, about a quarter of those breeds are currently endangered as they have been disused since the mechanization of farming and transportation, and have suffered massive losses during the first and second World Wars. These breeds were developed over long historical periods, in a variety of ecological and socio-cultural contexts. As such, they represent an invaluable component of our common genetic and cultural heritage and the living incarnation of European terroirs. Our proposal aims at undertaking the first genetic monitoring of ~120 endangered and autochthonous European breeds at a genome-wide level. Our extensive genetic dataset will enable a precise reconstruction of the horse breeding history in Europe, revealing the long-debated origins of iconic breeds and the genetic impact of different management strategies and environments. Additionally, it will open for an identification of breed-specific Ancestry Informative Markers and an estimation of key genetic parameters and population structure, allowing the development of informed conservation guidelines, aimed at maximizing the genetic potential of endangered breeds and minimizing mixing between breeds of unrelated history. Importantly, ENDANGEREDHORSES will showcase the potential of genome-wide approaches in helping preserve the genetic diversity of livestock resources, which is currently of concern for horses and all other domestic animals worldwide.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Multi-Modal and Multi-Aspect Holistic Human-Robot Interaction' (FORTIS).

assistant: **Innovation**

The European Union (EU) has experienced a decline in employment rates in various sectors such as industry, construction, and healthcare, with an aging workforce exacerbating the issue. To improve overall life standards and welfare, the EU's Horizon Europe programme is investing in emerging technology such as robotics and AI.FORTIS specifically focuses on providing a complete Human-Robot Interaction (HRI) solution that includes multi-modal communication and multi-aspect interaction. The goal is to develop a human-centric solution that addresses the needs of both the human workforce and the robots, allowing them to work together efficiently and safely. With cutting-edge research and advanced technology, this solution can help to mitigate the negative effects of an aging workforce on employment, working conditions, and welfare in the EU.The project will conduct three main pilots in the sectors of construction, infrastructure services, and manufacturing. These pilots will provide a total of 5 use cases to demonstrate the effectiveness and safety of the Human-Robot Interaction.Moreover, FORTIS will allocate a portion of the budget to finance pilots that allow civilians to interact with the robots in different settings, such as healthcare, public events, shopping centres, and grocery stores. This will provide an opportunity to evaluate the performance of the HRI solution in various real-world scenarios


**Keywords:** Multi-modal interaction,Multi-aspect interaction,Holistic approach,Social robotics,Cultural robotics,Ethical robotics,Psychological robotics,Verbal & Non-verbal communication,Haptic feedback, AI