RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Homologous recombination in plants (PLANTREC)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Major advances have been made in knowledge of plant genomes and the recombination processes regulating their structure and integrity. However exploitation of this is limited by absence of methodology for the targeted, in site modification of plant genes and chromosomes. In plants the somatic homologous recombination machinery is overwhelmed by another recombination process (NHEJ) , which causes incoming DNA to insert at a random position in the genome, often accompanied by unwanted rearrangements. This is an important reason for questioning the safety of transgenic crops. We directly address these issues and 5 academic and 2 industrial research groups together aim to develop novel tools to obtain gene targeting in plants, based on a detailed understanding of recombination in plants. The groups will contribute considerable novel expertise and biological material to the project: plant hyperecombination mutants, cloned genes and proven assays.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Novel Biomaterial-based Device for the Treatment of Progressive MS-   - An Integrated Pan- European Approach'.

assistant: **Concept**

PMSMatTrain is focusing on gaining a comprehensive understanding of the progressive (late degenerative phase) of multiple sclerosis (PMS) from basics to translation, fully supported by 8 beneficiaries (6 research institutions, 2 SMEs). Recruited ESRs will receive compulsory discipline-specific, generic and complementary transferable skills training. PMSMatTrain’s Joint Research Education and Training programme (JRTP) will provide early stage researchers with high quality research and transferable skills training in intellectual property, leadership skills, innovation, regulatory affairs, entrepreneurship, gender policy, and medical device evaluation, which will ensure that they are immediately employable in industry. The consortium will develop a multi-modal hyaluronan-based medical device designed to release small molecular weight anti-inflammatory molecules (APRIL and sPIF) followed by remyelination and neuroprotective drugs (ibudilast and miconazole). PMSMatTrain will for the first time utilise these functionalised multi-modal biomimetic hyaluronan scaffolds as a tool to investigate cross-talk between signals arising due to chronic neuroinflammation and those leading to demyelination and axonal loss, while identifying molecular mechanisms that facilitate remyelination and neuroprotection in PMS. This approach could yield the first cortex-proximal and directed biomaterials-based disease-modifying therapy for PMS. These scaffolds will be tested in state of the art MS patient induced stem cell-derived oligodendrocyte cultures and organotypic cultures to investigate MS pathophysiology. In vivo responses will be characterised using field-leading MRI and mass spectrophotometry protocols. PMSMatTrain will also generate a clinically-relevant in silico model of drug elusion a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Towards Efficient and Stable Perovskite Light-Emitting Diodes' (PeLED) under Horizon 2020.

assistant: **Objectives**

Light-emitting diodes (LEDs) based on organometallic halide perovskites have attracted increasing interest due to their unique properties, such as high colour purity, easily tunable optoelectronic properties, and solution processable for low-cost and large-arear manufacturing, showing great potential in displays and lighting applications. Even though the photonic and electronic properties of perovskites are very attractive, the poor stability and relatively low photoluminescent efficiency are two major problems that limit their progress in LEDs. In this project, I aim to address these challenges and develop efficient and stable perovskite LEDs. I propose a) to design and synthesize Ruddlesden-Popper perovskite (RPP) emitters with stable crystal structures and excellent optoelectronic properties, with the help of first-principles calculations, b) to deposit high-quality RPP films using new synthetic routes, and c) to fabricate efficient and stable LEDs with performance beyond the state of the art, by coupling device engineering with device physics investigations. This project will increase the fundamental knowledge concerning RPP materials and devices. The expected outcomes are new type perovskite materials with good optoelectronic properties, as well as stable and efficient LEDs. In addition, I will be trained to develop new interdisciplinary knowledge and skills and to reach professional maturity by implementing the project. In addition to individual development, successful implementation of this project will also promote the international competitiveness of the host organization on research of perovskite optoelectronics. Potential commercialization of the new perovskite materials and LEDs products will also generate economic growth and new job opportunities for the Eu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Control of cerebral blood flow by capillary pericytes in health and disease' (BrainEnergy), addressing dissemination and exploitation.

assistant: **Impact**

Pericytes, located at intervals along capillaries, have recently been revealed as major controllers of brain blood flow. Normally, they dilate capillaries in response to neuronal activity, increasing local blood flow and energy supply.  But in pathology they have a more sinister role. After artery block causes a stroke, the brain suffers from the so-called “no-reflow” phenomenon - a failure to fully reperfuse capillaries, even after the upstream occluded artery has been reperfused successfully. The resulting long-lasting decrease of energy supply damages neurons. I have shown that a major cause of no-reflow lies in pericytes: during ischaemia they constrict and then die in rigor. This reduces capillary diameter and blood flow, and probably degrades blood-brain barrier function. However, despite their crucial role in regulating blood flow physiologically and in pathology, little is known about the mechanisms by which pericytes function.By using blood vessel imaging, patch-clamping, two-photon imaging, optogenetics, immunohistochemistry, mathematical modelling, and live human tissue obtained from neurosurgery, this programme of research will:  (i) define the signalling mechanisms controlling capillary constriction and dilation in health and disease;(ii) identify the relative contributions of neurons, astrocytes and microglia to regulating pericyte tone;(iii) develop approaches to preventing brain pericyte constriction and death during ischaemia;(iv) define how pericyte constriction of capillaries and pericyte death contribute to Alzheimer’s disease; (v) extend these results from rodent brain to human brain pericytes as a prelude to developing therapies.  The diseases to which pericytes contribute include stroke, spinal cord injury, diabetes and Alzheimer’s disease. These
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Sized-based tools for managing freshwater fish communities'.

assistant: **Innovation**

- To implement a monitoring programme for fish communities based on the biomass size distributions of the fish and their resources, and on the biomass size distribution of the phytoplankton community in an environmental gradient over a wide geographical range in Europe.- To analyse factors determining fish community size distribution within different habitats, relating present size distributions and size related characteristics such as growth, maturation/fecundity and mortality to the resource size distribution and environmental variation.- To derive size-dependent competitive ability relationships of major key species on different prey resources along the productivity gradient of European lakes.- To assess the consequences of different size selective harvesting strategies for inter- and intraspecific competition and hence for the structure and the dynamics of the fish communities along a productivity gradient of lakes.- To examine 'causes for the generation of size variation among individuals, especially in early stages of life by using individual-based modelling and experiments in controlled systems and to analyse how the scaling of foraging capacity to body size affects the likelihood of cohort slitting.The project was started 1. April 1997 and will last for four years ending 1. April 2001. As the project is newly started, few results are yet available. This article summarizing the planned work and dissemination activities.DISSEMINATION ACTIVITIESTwo project meetings have been arranged in 1997, one in March and one in October. The kick-off meeting in March discussed the research strategies and made decisions on methodology. In the October meeting all partners presented results from the first year, which were analysed at the task level. The partners have to variable e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The interaction and clearance of senescent vascular cells by the innate immune system' (ICSIS) under Horizon 2020.

assistant: **Objectives**

Cell senescence plays a paradoxical but important role in physiology; it protects organisms against cancer but also contributes to age-related loss of tissue function. Senescent cells accumulate during ageing, particularly at sites of age-related pathologies such as vascular tissue, contributing to fibrotic cardiovascular disease , . Therefore, the aim of this research is to understand why senescent cells accumulate later in life for the purpose of identifying potential therapeutic strategies for eliminating senescent cells. This project, founded in an emerging field of ageing research, will determine the interaction and clearance of senescent cells by ageing innate immune cells.  Using in vitro, ex vivo and in vivo approaches the fellow will delineate the mechanisms of interaction between senescent vascular cells and the innate immune system and how they are impacted by age. This will significantly advance knowledge and lead to novel molecular targets to explore for eliminating age-associated vascular senescent cells.  Since the field of cellular senescence is predominantly centred within molecular cell biology and cancer, this coordinated cross-disciplinary and cross-sectorial approach will provide novel insight into vascular senescence. Through an ambitious research training programme, the fellow will develop scientific, complementary and transferable skills in metabolism, innate immunity and vascular function in age-related disease from Aston, UK with intersectorial training to develop small molecule drugs from Redoxis SB, SWE; evaluate drug efficacy in models of ageing (Erasmus, NL); in the context of clinical cardiology (Aston/City Hospital, UK). It will deepen collaborations for partners, provide new techniques to the hosts and enhance the skills of exceptionally
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Fabrication & characterisation of protective HEA films on Mg substrate by mechanical alloying, cold spraying & post-surface laser annealing processing' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Protective high entropy alloys (HEA) thin films/coatings on Mg substrate will be produced by mechanical alloying (MA), cold spraying (CS) and post-surface laser annealing (SLA) process. By using variable but controlled MA process and CS  coating parameters (HEA feedstock powder & HEA MAed powder characteristics, CS technology geometric parameters, CS deposition parameters), variations in the micro-structure and property in HEA coatings will be attained. Microstructural characterization of HEA feedstock powders, MAed powders, CS coatings and CS+post-SLA coatings will be carried out by SEM, TEM, XRD, porosity measurements. Wear, oxidation, corrosion tests, hardness and elongation measurements will be made to determine chemical and mechanical properties of coatings. With this way relationships among deposition parameters-microstructure-properties will be determined in addition to the feasibility study of producing protective (wear and oxidation resistant) HEA coatings on Mg-parts by combined MA+CS & post- SLA process.


**Keywords:** HEA film on Mg parts, mechanical alloying, cold spray, laser surface annealing, materials characterization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Policy incentives for climate change mitigation techniques'.

assistant: **Objectives**

In the Kyoto protocol context, PICCMAT aims at identifying and promoting changes in land managements practices to mitigate greenhouse gas emissions. The Common Agricultural Policy includes different tools in its rural development policy to orientate farmers' practices and environmental impact. These tools (mainly agri-environment measures and cross-compliance obligations) are expected to include climate change mitigation related measures. This project will provide objective information to develop guidelines for the design of climate change mitigation policy incentives. The project has three main objectives: 1) To provide scientific information for the development of policy related to agricultural practices and climate change mitigation. This will be realised through an extensive analysis of the potential mitigation options in land management practices. It will involve a close cooperation with past and on-going research projects, case studies in major European climatic regions, and a modelled quantification of the global impact of the introduction of selected practices. 2) To reinforce the links between policy makers and scientists in the field of climate change and agriculture. During its entire duration, PICCMAT will maintain close exchanges with EU policy makers and scientists through its Project advisory board and the organisation of workshops and seminars. EU-27 National authorities involved in the elaboration of the NRDP will be identified and directly involved in the project. 3) To raise European farmer awareness on the impact of agriculture on climate change. Through the organisation of an awareness campaign targeted at major agricultural organisations, PICCMAT will ensure a large dissemination of its results. The consortium built for the PICCMAT project includes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Water reuse in Mediterranean Countries' (WATEREUS-MED) under Seventh Framework.

assistant: **Objectives**

This project proposal is aimed to support and strengthen the different existing collaboration actions between Europe and Mediterranean Partner Countries (MCP) for research and research training in the field of Water reuse through the staff exchange opportunities offered by IRSES. The structuring action of the programme consists in co-advising PhD students between the two sides of the Mediterranean Sea.A number of researchers and practitioners from Italy, Germany, France and Austria would bring their experience and vision to MCP and face local challenges, while MPC researchers and managers would mainly visit problems and projects sites in EU to see with their eyes the rationale and benefits of Water reuse technologies. Joint research activity to face selected case studies, site visits, workshops, sharing of publication and information and the set-up of a joint web site are the main foreseen activities.The overall objective of the WATE-REUSE-MED Project is to strengthen research cooperation and training in Mediterranean Countries and Europe within the water related sciences. This will be done by setting up a collaborative exchange programme for experienced and early stage-researchers with mutual benefits for all Participants. More specifically, the project is aimed to support visits researchers from Jordan, Tunisia, Egypt and Lebanon, to European Institutions and from European countries to the Mediterranean Research Centre, with short exchanges (1-2 months) for senior and longer exchanges (2-12 months) for junior investigators, for a total of about 1800 months. Scientific results thereby obtained will parallel advanced training and acquisition of new technologies in water reuse.The present project proposal is therefore aimed to add a high value to the whole activity by th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Mechanistic models of leukemia-niche interaction using multimodal single cell profiling'.

assistant: **Objectives**

The bone marrow is one of the most dynamic adult stem cell niches containing hematopoietic stem cells and non-hematopoietic mesenchymal stem and stromal cells, which make up the bone marrow niche. The niche regulates the immune system and constitutes a major determinant of chemoresistance in hematological malignancies, including acute myeloid leukemia (AML). Identifying the mechanisms by which AML interacts with its niche will open novel therapeutic avenues.AML is driven and maintained by leukemic stem cells (LSCs), and failure to eradicate them will result in relapsing of the disease. Yet, despite decades of research on LSCs, none of the therapies aiming at eradicating them reached clinical practice. Recent studies suggest an important role for bone marrow stromal and immune cells in driving AML. Together with our preliminary data, that show LSCs-induced upregulation of metastasis-related genes in stromal cells, this leads to the hypothesis that AML remodels its niche in ways that favours its survival and represses healthy hematopoiesis. Most studies in AML focus on LSC-intrinsic, stromal niche, or immune mediated mechanisms separately. Thus, we currently lack a comprehensive view of the complexity of the human bone marrow and its interaction with AML. To close these gaps, we propose an ambitious experimental design including multi-modal single cell sequencing of an AML cohort followed by innovative computational approaches integrating these data into predictive cell-type specific models - to generate mechanistic hypotheses about AML-niche interactions that we then test using patient-derived xenograft and in vitro culture models. Our ambitious project will provide fundamental insights into stem cell-niche interactions and may lead to a paradigm-shift in treating hemato
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Communicating environmental impacts on water quality, availability and use' (COMENVIR).

assistant: **Concept**

The ComEnvir project aims to narrow the gap between EU sponsored environmental research and European citizens. Water (resources, quality, pollution and biodiversity issues) has been chosen as a common theme to be addressed by the project. It will cover environmental stressors, waste treatment, health effects, biodiversity, risks and therefore the role of water quality in its different environmental locations (fresh water, marine, soil, air). The project will last 48 months.  The project will communicate results and activities of EU environmental research with two specific target groups. The primary target group are teachers and students. The second target group is the general public.   The overall project objectives are to:  • empower the European citizens to  constructively engage in scientific dialogue and debate  • inform European consumers of the latest scientific advances in the food sector • strengthen science education in classrooms and  • promote scientific curiosity among the youth   The ComEnvir project  will achieve its set objectives through a number of innovative approaches and strategies that have already been piloted in 2006 and 2007. These approaches centre around three key elements: • creation of knowledge packages on EU environmental research and will include films, film clips, FAQs, news, background reading materials, a glossary and links • effective dissemination measures (broadcast media, DVDs and internet) and • thorough evaluation of on-going project deliverables  The  nine project members, located in Denmark, France, Germany, Italy, The Netherlands, Norway and the UK possess complementary expertise that assures successful project outcome. The project will last 48 months.