RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PROteomics SPECification in Time and Space' in the context of a Seventh Framework call.

assistant: **Objectives**

Proteomics is a major new field in biomedical research, which deals with the large-scale identification and characterization of large groups of proteins, or “proteomes”. These can either be the components of a subcellular organelle or compartment, or even the entire protein complement of whole cells and tissues. Proteomics is essential in the functional annotation of the genome and in future attempts to build a quantitative, ‘systems-based’ description of cell biology. However, current ‘first generation’ proteomics approaches largely measure protein complexes and proteomes as homogeneous and static entities with little or no quantitative annotation. PROSPECTS (PROteomics SPECification in Time and Space) is a proposal by world leaders in this young discipline to make a major advance, both by developing much more powerful instrumentation and by applying novel proteomics methods that will allow us to annotate quantitatively the human proteome with respect to protein localization and dynamics. Complementary technologies, including mass spectrometry, cyro-electron microscopy and cell imaging will be applied in innovative ways to capture transient protein complexes and the spatial and temporal dimensions of entire proteomes. We will develop these new proteomics technologies in a generic fashion to maximize their utility to the wider biomedical community and we will generate comprehensive data sets that will foster many downstream functional studies. Our approaches will also generate unique insights into the molecular basis of multiple forms of human disease, specifically neurodegeneration and other diseases related to folding stress. The multidimensional data sets generated in PROSPECTS will be integrated using advanced data aggregation and machine learning, made available to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Optimal organisation of health care in diabetic foot disease (EURODIALE)' (EURODIALE) under Fifth Framework.

assistant: **Objectives**

Diabetic foot disease is one of the most feared complications of diabetes; it has important effects on quality of life and poses important demands on the health care system in terms of manpower and costs. At this moment there are approximately 660.000 diabetic individuals in Europe with a foot ulcer and approximately 70 000 will undergo a lower-limb amputation. Earlier studies suggest that health care organisation is one of the most important determinants of the outcome of a diabetic foot ulcer. The present project aims to determine the optimal health care organisation for these patients, taking potential differences in patient characteristics and management strategies into account. As outcome variables will be used:1) clinical endpoints,2) quality of life and3) economic costs. Data will be collected in 14 diabetic foot centres from different regions of Europe. The results will also facilitate the formulation of best evidence based practice in management of diabetic foot disease" to optimise and harmonise strategic and organisational aspects of care, taking differences in health care systems into account."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Investigating the fern diversity of the Mascarene Islands using phylogeographic approaches' in the context of a Seventh Framework call.

assistant: **Objectives**

The South West Indian Ocean islands are an official hotspot of biodiversity and endemism (Myers et al., 2000). Among these islands, the Mascarenes consist of three main islands: La Reunion, Mauritius and Rodrigues. These islands differ in size, elevation profile, age, distance to the next larger land mass (Madagascar) and biodiversity. The Mascarenes are particularly rich in plants species, with about 1,300 vascular plants, of which 585 are endemics. Ferns form an important flora component in the very diverse biotas of the islands, especially in tropical forest. Most ferns disperse easily via their spores, allowing frequent colonization from Madagascar but also exchange among the Mascarene islands. We propose to perform an integrated phylogeographic study of selected groups of ferns with a view to elucidating the processes creating these islands diversity. To this end, we will integrate ecological data to explore the biotas of each island, population genetics, and  cytological data to explore polyploidy. The study will also take into account the fern gametophytic phase, too often neglected in fern studies. We will particularly investigate the importance of apomixis. This study is expected to help identify characteristics that allow ferns to successfully colonize islands.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of DNA-based nanodevices for the point-of-care detection of clinically-relevant proteins' under Horizon Europe.

assistant: **Concept**

WHY: The detection of specific proteins that are overexpressed in different types of cancers is critical for early diagnosis and targeted cancer screening. Existing methods for quantifying these clinically-relevant proteins, including the enzyme-linked immunosorbent assay (ELISA), have the disadvantage of being a multi-step, reagent-intensive and laboratory-bound process which result in relatively high costs, limiting its applicability at the point of care. To overcome these limitations, new methods and approaches are urgently needed. WHAT: ProDNA-Nano aims to address this need with the development and characterization of a general class of cell-free DNA-based systems that can be used to quantify different cancer-related proteins through electrochemical and optical methods to maximize the versatility and applicability of the technology. Specifically, the innovative cell-free system developed in this project couples the specificity of protein-ligand binding with the high sensitivity of RNA-based detection, thus providing a versatile and efficient platform for protein quantification. Moreover, the proposed system will allow to quantitatively measure different protein concentrations directly in biological media in an orthogonal fashion, with reduced complexity and cost and rapid turnaround time. The modular nature of the system will also allow its adaptation to a wide range of targets, thus making it a versatile nucleic acid-based tool. HOW: Through a multidisciplinary approach, I will receive training in molecular biology, optical/electrochemical biosensors, and DNA nanotechnology. Prof. Ricci's group at the University of Rome Tor Vergata (UNITOV) offers extensive expertise in these areas, being at the forefront of DNA nanotechnology and biosensors development. Thanks to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Neuromorphic computing and signal processing training network' (MINDnet) under Horizon Europe.

assistant: **Objectives**

The exponential surge in artificial intelligence (AI), internet traffic, and online services demands a revolutionary leap in devices, computing architecture, and integration technologies. Current digital computing platforms, driving societal progress, are hitting fundamental limits such as quantum tunneling and facing technical challenges like energy efficiency and heat dissipation. As a result, the progress in AI is slowed down by speed bottlenecks, massive energy consumption, and limited access to AI technologies as only selected large industrial players can afford to commit the required resources. Inspired by the brain’s powerful and energy-efficient processing capabilities, neuromorphic computing presents a promising solution to these critical issues. However, to fully harness neuromorphic computing’s potential, a holistic optimization - from individual computing devices to the overall architecture, including a focus on applications, and training methods - across multiple technological platforms - photonics, electronics, biological neurons - is critically needed.  The proposal of MINDnet addresses these urgent challenges through an interdisciplinary approach, bridging traditionally separate fields. MINDnet’s mission is to train 15 Doctoral Candidates, forming the next generation of leading scientists and expert researchers in the field of neuromorphic computing.  MINDnet leans on a consortium of 10 beneficiaries - 7 universities, 1 tech-transfer research center, 1 multinational, 1 SME - complemented by 6 associated partners – 1 multinational, 2 SMEs, 2 tech-transfer research centers, and 1 academic.  The consortium spans over 8 European countries, combining experts in 5 research disciplines - photonics (DTU, UNITN, USTRATH), electronics (UCL, HPE, FZJ, SCS), nonline
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'EnAbling a Model-driven deep understAnding of the roLe of gender Towards a Holistic solution against Extremism and radicalization Activities' (AMALTHEA).

assistant: **Innovation**

Recent scholarship on y the gender dimension in preventing and countering violent extremism programming, still lacks thorough gender-sensitive data collection and analysis. On the one hand, empirical data and a gender-sensitive approach in counter violent extremism is needed to create lasting security. On the other hand, violent extremism concept does not have an agreed definition. The literature on Traditional Counterterrorism (TC) policy has been conducted from a gender-blind perspective, at the most adding women and “stirring” them into the existent mix, instead of meaningfully re-examining the underlying issues of gender and diversity dynamics. In this context, it is important to critically examine how the unequal socialization can lead to violence and become a driver of VE (Violent Extremism) by bringing in the feminist and intersectional perspectives into research design, data collection and analysis. A better understanding of the causes, manifestations, and mitigation practices of violent extremism is required, by critically examining the relationship between gender and extremism, investigating gender-specific factors for radicalization, such as community belonging, social connections, traumas or empowerment narratives. AMALTHEA will address the challenge of limited access to knowledge, collaboration and unified approaches against gender-related radicalisation via in-depth research and delivery of innovation in three complementary fields: (i) Knowledge creation, targeting LEAs, CSOs, social support professionals, teachers and other P/CVE practitioners; (ii) Knowledge modelling, management and sharing to improve understanding of the role of gender in VE/CVE; and (iii) Tailor-made tools for LEAs and CSOs that will enable engagement, collaboration, efficient policy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Development of an online-sensor-based washcontrol system and water recycling for use in textile dyeing houses and laundries'.

assistant: **Innovation**

Washing and rinsing processes represent very important and cost intensive steps in SME dyeing houses and laundries. Rinsing and washing is mostly performed under weak process conditions and without any controlling due to lack of suitable sensors. In order to get high quality products and excellent fastness properties the goods are usually washed too long and too intensely. Such a non-controlled washing process is very time consuming and requires a lot of water and energy. Within this project, a very innovative online sensor-based WashControl system will be developed for use in discontinuous dyeing ranges and in laundries, which will particularly enable water savings of at least 30% and economic recycling of process water with membrane technology. The sensor-controlled washing is marked by a online-measurement of the removed stain, so that several fillings of the washing apparatus can be saved.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Cell-specific delivery in therapeutics: application of the universal linkage system(uls) in the design of targeted drugs.'.

assistant: **Concept**

The Marie-Curie fellows will learn through research at KREATECH Biotechnology BV, at the Department of Pharmacokinetics and Drug Delivery (PK&DD) of the University of Groningen, and at the Leiden Institute for Chemistry (LIC) of the Leiden University in The Netherlands. The Department of PK&DD is highly skilled and experienced in the development of targeted drugs and in in-vitro and in-vivo testing of these drugs. The LIC is highly skilled and experienced in (in)organic combinatorial chemistry. All laboratories are modern and with state-of-the-art equipment. All institutes are (inter) nationally highly acknowledged and have extended (scientific) networks, both national and international. Moreover, all institutes have broad experience in guiding and teaching fellows at all scientific levels. KREATECH is a biotechnology industrial organization with patents on the Universal Linkage System (ULS^(R)) and Mycobacterium diagnostics (ABC). KREATECH has broad knowledge of the biochemical and biological properties of ULS^(R) and on the development and production of biochemicals and diagnostical based on these patents.In this project, ULS^(R) will be applied in the design of targeted drugs. The problem of cell-specific drug delivery will be tackled through biochemical and biomedical research at two fronts:1) the linkage of small chemical drugs that cannot be linked to homing devices by conventional chemistry, and2) the linkage of bio-active therapeutic peptides to carrier proteins through a drug-releasing bond (release at target site). The developed drug prototypes will be tested both in-vitro and in-vivo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'FRAGMENT screening from advanced-sampling molecular dynamics simulations on a proteOME scale.'.

assistant: **Innovation**

In Fragment-Based Lead Discovery (FBLD) highly sensitive biochemical and biophysical screening technologies are used to detect the low-affinity binding of low-molecular-weight compounds (the so-called fragments) to biological targets that are involved in pathophysiological processes. Knowledge of the molecular interactions between fragment hit(s) and the target protein allows the rational generation of high-quality leads for drug development. Thus, high-resolution (e.g. X-ray crystallography) and relatively high-throughput structure determination technologies are key to this approach but they can become a limiting factor for both technical and economical reasons. As a matter of fact, when the experimental characterization of binding mode fails, the success rate of FBLD approaches drastically drops. To overcome current limitations in FLBD, here we propose the development of a computational framework based on advanced-sampling molecular dynamics simulations to map the binding of fragments to protein surfaces on the proteome scale---thus generating the Fragmentome Altas. For each individual target this will allow to: a) systematically identify fragments binding to protein surfaces and cryptic pockets; b) reconstruct the mechanism of binding with atomistic spatiotemporal resolution; c) characterize the molecular determinants of affinity and kinetics in fragment-protein complexes. This insight is fundamental for optimizing and evolving fragments to lead compounds with desired thermodynamics and kinetics features. To date, neither experimental nor computational approaches can provide such information at affordable costs while maintaining the high throughput needed for screening campaigns. The successful implementation of this ambitious project lies in the unique combination o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Partnerships for pathways to Higher Education and science engagement in Regional Clusters of Open Schooling' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

PHERECLOS builds upon the theory of science capital and the experience that Children’s Universities (CUs) have made in the Third Mission of universities. With their engagement with children and young people, they became intermediaries between various actors in the educational and social landscape. As translators of the concerns, messages and knowledge of other parties (incl. business and industry, the state, civic society organizations etc.) they help to dismantle institutional boundaries of universities towards a wider society. The project will establish 6 ""Local Education Clusters"" (LECs), which bring together schools and further relevant actors in the education ecosystem of a particular pilot region, supported by a peer mentoring programme. The LECs will be incubators for enabling a dialogue between various parties and help to set up joint activities in (formal and non-formal) education, which help to develop collaborative learning environments as experimental testbeds for schools. At the same time they impact on the quality of science engagement opportunities in these areas. PHERECLOS will implement a digital “OpenBadge” ecosystem which labels institutions as reliable and responsive actors and showcases all LEC parties to become real change agents in education. At the same time, this ecosystem will testify individual achievements with respect to STEAM engagement in formal or non-formal settings or even unintended learning outcomes. The regional effectiveness and impact will be monitored by academic transfer and implementation research and lead to the development of implementation guidelines and policy briefs to enhance the sustainability of the overall approach. PHERECLOS promotes the territorial dimension of local education clusters in all their manifold facets a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Immunity, DEvelopment and Microbiota: Understanding the Continuous Construction of Biological Identity' (IDEM) under Horizon 2020.

assistant: **Objectives**

The problem of biological identity (what counts as one individual organism, and what makes each individual organism “the same” though it constantly changes through time?) has a long history both in philosophy and in science. Recent data coming from immunology, microbiology and developmental biology may revolutionize our conception of the construction of biological identity through time, by showing that this construction depends crucially on environmental factors and, most importantly, on a constant dialogue with symbiotic microorganisms integrated into the organism. IDEM, a fundamentally interdisciplinary project at the interface between philosophy and biology, aims at: i) determining to what extent it is adequate to see this shift as an ongoing “microbial revolution” in today’s biology; ii) understanding the exact processes by which developmental processes in organisms depend on microbial symbionts; iii) asking whether the role of the immune system (usually seen as a system that rejects genetically foreign elements from the body) in the maintenance of the organism needs to be reevaluated; iv) how traditional conceptions of biological individuality will be modified by this revolution. If funded, this project will provide a new understanding of the way living things are continuously constructed through time and interact with their biotic environment.