RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Standing with electrical neuromuscular stimulation applying tactile and proprioceptive information obtained fromnatural sensors'.

assistant: **Concept**

Functional Electrical Stimulation (FES) has been investigated for several decades. FES can restore some mobility in spinal cord or brain injured patients who are otherwise confined to their wheelchairs. However, despite intense research efforts, present day FES has found limited application because of poor control systems, which are often open-loop. Moreover, the systems are difficult to handle for patients on a daily basis and hardly acceptable from a cosmetic point of view. IQ this European Shared Cost RTD project, which includes seven Centres of Excellence, we seek to improve control schemes for FES systems by selective muscle recruitment via nerve stimulation and the inclusion of feedback information from the body's own sensory system. Natural sensors are abundantly available in the body and they are of paramount importance in the normal physiology of motor control. With the use of neural sensing and nerve stimulation the largest part of the FES system can be fully implantable, thus solving a part of the daily burden and acceptability for the patients. Within the time frame of the BIOMED 2 Workprogr we focus on a system for paraplegic standing. Paraplegic persons are not able to stand without assisting devices and are thus unable to perform trivial tasks, although by far the largest part of their neuromuscular system involved in standing-up, standing and sitting-down remains viable. We intend to design a system to bring about a safe and smooth transition from sitting to standing and from standing to sitting, as well as a safe prolonged standing. It will Consist of three parts: Sensing, Control and Stimulation. Signals are recorded with cuff electrodes placed around different peripheral nerves innervating the natural sensors of the foot sole and structures in and aro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The effects of hypercholesterolemia on tendon health (Tendon Health and CHolesterol)' (THaCH) under Horizon 2020.

assistant: **Objectives**

Musculoskeletal disorders, particularly to the muscle-tendon unit, are a major cause of occupational disability in the European Union. The link between high cholesterol and poor tendon function has recently been demonstrated by several groups. However, the underlying pathophysiology of this association remains unknown. Cholesterol is known to leave the circulation and accumulate in extracellular matrix through interactions between LDL and glycosaminoglycans (GAG). Tendons are GAG rich in the interfascicular matrix (IFM: a tendon structure facilitating collagen fascicle sliding and extension). One putative mechanism by which high cholesterol may impact tendon function is an accumulation of cholesterol and LDL in the IFM, impairing fascicle sliding and extension. In addition, LDL readily becomes oxidized (oxLDL) when entrapped in the extravascular space, and recent data demonstrates this negatively impacts tendon cell phenotype, altering normal gene expression. This proposal aims to enhance our understanding of hypercholesterolemia on tendon health; a highly under-researched area of significant clinical importance. It employs expertise in tissue mechanics and tendon cell biology available at the host and external institutes to probe the mechanisms linking high cholesterol and tendon pathophysiology. The underlying hypotheses are that in individuals with elevated total cholesterol and/or LDL, cholesterol accumulates with LDL in GAG-rich areas of tendon like the IFM, inhibiting tendon biomechanical function. This hypothesis will be explored using suitable laboratory models, allowing the reversibility of these changes and their impact on tendon adaptation and healing to be examined. The findings will have immediate implications for orthopedic sciences, preventative medicine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Osmium alloys & the pulse of the Earth'.

assistant: **Concept**

Our knowledge about the geological history of the Earth is almost exclusively derived from studies of the Earth's crust, the ~35 km ultra-thin skin covering our planet. There are indications that most of the continental crust has been produced during a few, short-lived bursts - so-called 'super-events' - throughout Earth history, but the issue is controversial. If true, these global events almost certainly had a major impact on the development of the atmosphere, on the evolution of life on Earth and on the formation of world-class mineral deposits. Processes in the Earth's mantle must have played a major role in these proposed 'super-events'.The aim of this project is to study the vital clues about the large-scale melting events in the history of the Earth that are preserved within the mantle in the form of tiny grains of alloys of the element osmium (Os). Os alloys form when parts of the mantle are melted to a high degree. The formation of these alloys can be dated using the different isotope proportions of osmium. An innovative, multi-faceted approach - already tested by pilot studies – is proposed. The goal is to collect a large number of Os alloys from key river and beach placer deposits worldwide, followed by Os isotope analysis using time- and cost-effective methods, thus constructing a global record of the history of mantle melting. This will allow for a rigorous and systematic testing of the mantle super-event hypothesis.Reaching across to other scientific disciplines, this project will also target some alluvial gold deposits that were already exploited by man in pre-historic times, as the Os isotope distributions of Os alloys mixed with this gold will not only yield new data on the global mantle super-events, but can also be used to define the characteristic Os
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Interaction between human dendritic cells and gamma delta T cells/NK cells in neonates' in the context of a Sixth Framework call.

assistant: **Objectives**

Dendritic cells (DC) are professional antigen-presenting cells that represent an essential link between innate and adaptive immunity. While DC maturation is triggered by direct toll-like receptor engagement, it can also be initiated when DC interact with other cell types acting at the innate phase of the immune response like gamma delta T cells and natural killer (NK) cells. Gamma T cells can induce DC maturation and, when activated, induce the production of IL-12, an effect that involves gamma delta T cell-derived IFN-gamma. Interestingly, it has been recently shown that neonatal gamma delta T cells, in contrast to neonatal gamma delta T cells, are not deficient in IFN-gamma production. Also a cross-talk between DC and NK cells has been demonstrated. The primary objective is to identify strategies that might overcome the inability of neonatal DC to produce bioactive IL-12. This will contribute to the development of new adjuvants able to induce efficient Th1-type responses in human neonates. As it has been shown that IFN-gamma restores IL-12 production in neonatal DC, the focus will be to find cellular sources of IFN-gamma in human newborn. The primary candidates we will investigate are gamma delta T cells and NK cells. In a second line of research, we will t ry to identify new molecules involved in the maturation of the neonatal immune system via an unbiased approach, namely DNA microarrays. The expertise of the host institute (dendritic cells, neonatal immunology) clearly complements the background of David Vermijlen (human gamma delta T cells, NK cells, microarray experience) that will result in a synergistic effect and contribute to the scientific excellence of the European Union. In addition, David Vermijlen will return to Belgium, his country of origin, to become
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Crucial intermediates in photosynthetic water splitting detected by time-resolved X-ray absorption spectroscopy (XAS) with synchrotron radiation' (XAS) under Sixth Framework.

assistant: **Objectives**

Photosynthetic water oxidation by plants and cyanobacteria proceeds at a manganese complex bound to Photosystem II. It is a process of crucial importance for sustaining the atmospheric gas composition and for primary biomass production. The proposed fundamental research is aiming at an improved mechanistic understanding; European initiatives aiming at biological or bio-mimetic hydrogen production are supported. By identification of intermediates of the O2-formation a crucial 'bottleneck' in the field is tack led. By X-ray absorption spectroscopy (XAS, XANES, EXAFS) the changes in oxidation state and structure of protein-bound metal complexes in its functional cycle can be efficiently investigated (BioXAS method).The proposed time-resolved BioXAS on intermediates in the oxygen-formation transition represents an innovative and novel experiment, which, to our best knowledge, is not pursued by any other group in the world. Of high priority is the training of the researcher in state-of-the-art BioXAS methodology to a level where he can prepare and lead BioXAS experiments independently, e. g. at the Beijing synchrotron. Further strategically objectives are (i) to strengthen and develop the BioXAS methodology in Europe and (ii) to establish the formation of BioXAS expertise in China and long-term Sino-European cooperation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Children, citizenship and internal migration in the European Union' (1994-1998).

assistant: **Innovation**

Research objectives and content This proposal is designed to enable me to spend time developing the Portuguese dimension of a large. inter-disciplinary, comparative research project on children and migration in the EU (involving Greece, Sweden. the UK and Portugal, funded by the European Commission and The Nuffield Foundation and co-ordinated by the applicant). The wider project builds upon the findings of a previous EC funded project on gender and internal migration (Ackers, 1995), which provided important information about the structure of EU migrant households. This proposal focuses on children growing up in these households, in the EU. It seeks to examine children's involvement in the migration decision and their understandings of the impact of migration on family relationships and roles: their legal status as recipients of educational and other social services; their identity and sense of belonging and their life chances. The research will also consider the impact of family breakdown on this group of children. particularly where their parents have a different national origin. The project involves detailed study of EC law and its implementation in four Member States together with the collection and analysis of both quantitative and qualitative data. Training content (objective, benefit and expected impact)  The specific training element. for the host institution, includes the development of expertise in the methodology of comparative research. and in particular in the use of computer-assisted analysis of qualitative data (using Nud.Ist). In . addition. training in European Community law particularly the social dimension . will be provided both by myself. as applicant. and also by close liaison with Jo Shaw (Jean Monnet Professor in European Law and Director of the C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Acceptable robotiCs COMPanions for AgeiNg Years' (ACCOMPANY) targeting Seventh Framework.

assistant: **Abstract**

The proposed ACCOMPANY system will consist of a robotic companion as part of an intelligent environment, providing services to elderly users in a motivating and socially acceptable manner to facilitate independent living at home. The ACCOMPANY system will provide physical, cognitive and social assistance in everyday home tasks, and will contribute to the re-ablement of the user, i.e. assist the user in being able to carry out certain tasks on his/her own. Services to the user will be delivered through socially interactive, acceptable and empathic interaction, building on computational models of robot social cognition and interaction. The envisaged relationship of the user with the robot is that of a co-learner – robot and user providing mutual assistance for the user not to be dominated by the technology, but to be empowered, physically, cognitively and socially.<br/>The project combines a multidisciplinary consortium to tackle the technological as well as   human-centred and ethical challenges of the project. A state of the art service robot platform, Care-O-bot® 3 will be used to assess user requirements and user acceptance of the robot. Results from user studies will then be fed back to adapt the technology so that it better suits user demands and preferences. Throughout the project such formative feedback results in different iterations of the ACCOMPANY prototypes.<br/>Three test sites in three different European countries (UK, the Netherlands, France), as well as a dedicated showcase, will ensure an extensive evaluation process considering cultural differences.<br/>The ACCOMPANY system will be a novel technological solution TOWARDS facilitating independent living at home for elderly users. In addition, ACCOMPANY will specify and benchmark design and ethical guideli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Simulation Modeling to Improve Decision Making in Complex-Dynamic Environments', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The overall aim of this project is to improve decision making in the presence of dynamic complexity, which is a challenging task. The main reason behind this challenge is the inadequacy of our intuitive skills in coping with complex dynamic decision-making situations. Dynamic complexity often overwhelms human decision makers, leading to poor decisions. Effective learning cannot typically take place in complex decision making environments. Simulation game based human experiments show that performances of participants initially improve, but quickly plateau at substantially non-optimum levels after a few trials with the same game. Most interestingly, the dynamic complexity we refer to does not necessitate hundreds or even tens of variables. It has been established that the dynamics of just 2-3 variables can be very complex, if their interactions involve delayed feedback loops and non-linear relations. Managing sustainable growth in public and private domains is a typical example of systemic-dynamic complexity. In early growth phases, growth is relatively easy and the decision makers do not recognize the approaching limits, especially since such limits are not fixed, but dynamically created by the very growth process itself. When the growth limits are recognized, it is often too late to avoid the imminent collapse, due to delays and non-linear effects in the system. The main objective of this project is to explore the roots of such decision complexities on relatively small simulation models and suggest methods and heuristics to improve decision making in complex environments. System dynamics method will be used in building models that will then be converted into interactive games on which decisions of subjects will be tested. A training method will be developed and tested f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mera - Ethical, accurate drug development' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Using patented fluid management technologies, the Mera system has the ability to culture, drug & stain 3D tissues on a large scale while monitoring everything in real time, through a fully automated florescent microscope.  3D microtissues are added to a dedicated consumable bio-plate. The plate is then integrated into the main Mera system. A chemical cocktail can be introduced to selected wells on a plate in order to mature the cells into different tissue types such as liver, heart, neuronal or cancer. The fluid pathway can be changed to allow the introduction of a drug or stain to batches of multiple different tissue types. The fluid can then be recirculated, replicating the conditions in the human body where organs interact with each other.  The whole process can be monitored using the automated microscope in wide field or florescent modes. The system is modular & scalable, allowing a single unit to run up to 800 microtissues simultaneously.


**Keywords:** Personalised medicine,High Throughput Screening,Predictive drug discovery,Microphysiological systems MPS,Organ on a chip OoC,Microfluidics,3D cell culture,Automation and control systems,Automation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'The European Textile industry business-to-business portal of management and consulting services'.

assistant: **Concept**

SMEs play a fundamental role on the European economy, particularly in the fashion industry. This sector was hit over the last years. SMEs in particular have suffered major disadvantages when compared to large companies.Small and medium entrepreneurs are often self-made men who lack the culture of a systematic approach to decision making. Even when this is not the case, finding the right information and using it is a very difficult task, mostly beyond the reach of SMEs.The proposed project aims to build a web portal for management services to the fashion sector. Services will be structured in marketing intelligence, optimising tools and other management support systems.A consortium has been formed (an international team of specialists in different areas) for this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies' in the context of a Seventh Framework call.

assistant: **Objectives**

Coronary artery disease (CAD) is the leading cause of death in high-income countries. Invasive coronary angiography (ICA) is the reference standard for the diagnosis of CAD and allows immediate therapy. However, only 40% of patients undergoing ICA actually have obstructive CAD and ICA has relatively rare but considerable risks. Coronary computed tomography (CT) is the most accurate diagnostic test for CAD currently available. CT may become the most effective strategy to reduce the ca. 2 million annual negative ICAs in Europe by enabling early and safe discharge of the majority of patients with an intermediate risk of CAD.To evaluate this, we propose the DISCHARGE project that will be implemented by a multinational European consortium. The core of the project is the DISCHARGE pragmatic randomised controlled trial. The primary hypothesis will be that CT is superior to ICA for major adverse cardiovascular events (cardiovascular death, nonfatal myocardial infarction and stroke) after a maximum follow-up of 4 years in a selected broad population of stable chest pain patients with intermediate pretest likelihood of CAD. The trial will include 25 clinical sites from 16 European countries ensuring broad geographical representation. Comparative effectiveness research of complementing work packages include gender-related analysis, systematic review of evidence, cost-effectiveness analysis, and health-related quality of life. DISCHARGE has the capability to influence current standards and guidelines as well as coverage decisions and will raise awareness among patients, health care providers, and decision-makers in Europe about the effectiveness and cost-effectiveness of coronary CT angiography.