RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Regulation of cell-fate determination in the vertebrate neurogenesis by the mapk pathway in combination with the neurogenic genes delta and notch' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content  The objective of this project is the study of the mechanism that control cell-fate determination in early neurogenesis, using the chicken retina as a model system. Neurons of the vertebrate central nervous system are generated from dividing neuroepithelial progenitors cells. Lateral inhibition mediated by the neurogenic genes Delta and Notch is required to maintain these proliferating progenitors so that neurogenesis can continue. Our project approach the study of the role in vivo of mitogen-activated protein kinases (MAPKs) pathway and extrinsic signals (growth factors such as EGF, NT-3 and IGF-I) in cell-fate determination and the correlation of this pathway with the mechanism of lateral inhibition modulated by the Delta/Notch signalling. For this purpose we are planning to use retrovirus-mediated gene misexpression to interfere with the MAPK pathway and the extrinsic signals mentioned above. Training content (objective, benefit and expected impact) The project will provide training in different theoretical aspects of neurogenesis, signal transduction and gene regulation and a practical approach in a variety of molecular and cellular techniques, such as the alteration of gene expression using retrovirus. In addition I will benefit intellectually and practically from interactions with other ICRF laboratories that work on signal transduction and developmental neurobiology. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Light scattering investigation of bio-functionalised amphiphiles'.

assistant: **Objectives**

This research proposal is aimed to investigate, by means of light scattering and other optical investigation methods, self-aggregation effects and interparticle interactions in solutions of bio-functionalized surfactants.These compounds have an amphiphilic structure with biologically-inspired head groups (made for instance by a small number of nucleosides). As a consequence, they behave as 'smart' molecules capable of specific molecular recognition of a complementary head-group sequence, which makes them particularly appealing for the development of bio-nanotechnologies.Indeed, by appropriate control of the chemical functionalities codified in molecular structure, bio-functionalized amphiphiles self-assembly as micellar systems, vescicles, microemulsions, 'living polymers', or chiral structures, and can be used to design host-guest complexes and systems for enzymatic confinement.Main goal of the project is trying and establishing a link between the collective, non-specific, large-scale self-assembly phenomena that are usually investigated by soft matter scientists, and the short-range molecular specificity effects commonly seen as the driving force for association in biological fluids.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Functional organization of the multisensory motion system' under Horizon 2020.

assistant: **Concept**

One of the most significant current discussions in the understanding of the human brain is the functional recruitment of some regions of the cortex for specific tasks, regardless the sensory modality (e.g. visual, tactile or auditory) in which the stimuli is received. The ability to perceive motion, among others visual properties, is a fundamental faculty of the human brain. The predisposition to detect motion is present since the first months of life and is one of the main prerequisites for a child’s healthy brain development. Brain lesions that impair the detection and processing of motion have a profound impact on daily activity. Consequently, visual motion processing is one of the most fundamental and well-studied systems in the human brain, canonically known to develop mainly for the purpose of visual perception. The aim of this proposal is to elucidate in humans whether the functional recruitment and specialization of the visual motion system is independent of the sensory modality in which the stimuli are perceived, to characterize the sensory independent functional mesoscopic architecture within the brain regions involved and to establish their causal role in perception.  I will answer these questions using advanced methods such as ultra-high field fMRI at 7T, intracranial electrodes, transcranial magnetic stimulation and advanced neural based analyses. The integrated approach I propose here provides a unique multiangle perspective to investigate the neural substrate of multisensory processes. The fact that motion sensitive brain regions exhibit sensory-independent responses and that the same neuronal ensemble may respond to aspecific sensory features will challenge our notions on brain sensory segregation and functional development and will impact other high-lev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Maintaining Quantum Coherence for Quantum Information Applications'.

assistant: **Concept**

Quantum information technologies have attracted much attention in recent years. Advanced fabrication technologies have made it possible to develop quantum architectures, such as trapped ions, color-defects in crystals (nitrogen-vacancy in diamond), and Rydberg atoms, where quantum information applications can be implemented. At the heart of this growing field stands quantum coherence. Maintaining coherence for longer times enables the realization of richer and more interesting quantum applications, varying from quantum gates for quantum computation, through quantum simulation of classical intractable systems, to quantum sensing schemes for medical applications. Noise, leakage and decay channels constitute the main sources for decoherence, which limit the fidelity of the desired quantum operations. In this project my main goal is to theoretically investigate ways to maintain coherence in the quantum systems mentioned above, while realizing a variety of quantum applications. This will be done using either dynamical decoupling or quantum error correction techniques. A numerical verification of the theoretical proposals will be undertaken using Runge-Kutta simulations of the systems together with the Orenstein-Uhlenbeck noise process. Importantly, I intend to collaborate on the realization of the theoretical proposals with the relevant experimental groups. In this way, I will enrich my scientific knowledge regarding the specific decoherence sources in the different experimental setups, and thus, my theoretical investigation can be adjusted specifically to the experimental needs. Eventually, these experiment-theory collaborations will end up in experimental verification and application of the theoretical proposals, which will have high impact on research within and far beyon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Tools for the assessment of level and quality of service across different transport market segments' under Sixth Framework.

assistant: **Concept**

The TOOLQIT project answers to task 1 of policies 3.2 of the SSP programme of the Sixth Framework which objective is to develop and validate a framework for the assessment of level and quality of service across different transport market segments. Following the requirements, TOOLQIT has the following objectives:- To further develop and validate common definitions for levels of service (LoS) for all passenger and freight transport and intermodal transport;- to propose suitable indicators for level of service and quality of transport, both for nodes and for links;- to determine an accounting framework and method to measure these and assess impacts of policy actions through inclusion in an European transport network model;- to recommend procedures and roles in the exploitation, uptake and transfer of results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enabling politically sensitive climate change impact assessments for the 21st century' (POLIMPACT).

assistant: **Concept**

What are key climate-driven social risks, and how might societal development moderate these risks? The SSP-RCP scenario framework has been developed by the IPCC community to study long-term interactions between climate and society and constitutes the cornerstone of current assessments of climate change impacts. The RCPs represent alternative warming scenarios (hazards) whereas the SSPs describe alternative development scenarios that define exposure and vulnerability to these hazards. Despite their widespread use, the quantitative SSP scenarios suffer from two major shortcomings: (i) they ignore political dimensions of vulnerability, implicitly assuming that governance does not matter for climate-driven risk; (ii) they use economic models that ignore growth disruption risks, resulting in future growth projections for low-income countries that vastly exceed past growth even in the most pessimistic scenarios. The joint result of these shortcomings is a quantified scenario framework that severely underestimates future vulnerability to climate change.POLIMPACT aspires to remedy this problem. Using cutting-edge methods, including dynamic statistical simulations, machine learning, and expert elicitation, the project will develop a new portfolio of empirically grounded and rigorously validated governance, conflict, and economic development scenario projections, consistent with the SSPs, that for the first time enables accounting for political sources of vulnerability in climate change impact assessments. The scientific merit of the novel scenario products will be demonstrated by comparing impact estimates for poverty and hunger relying on the existing SSP framework with updated results using the extended, politically sensitive projections. If successful, POLIMPACT will initiate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Next Generation Microbiome Platform' (FlexiBiome) targeting Horizon 2020.

assistant: **Abstract**

PharmaBiome AG is an ETH Zurich spin-off company that was established in February 2015 after intense scientific interactions at ETH Zurich between highly qualified scientists and business professionals in the fields of biotechnology and gastroenterology. We envisioned a huge interest of the pharmaceutical industry in microbiome-based technologies.Our primary target market focuses on patients suffering from recurrent Clostridium difficile infections (rCDI), which are usually a consequence of antibiotic use. Almost 900.000 cases of CDI in the EU and USA may occur each year bringing the acute-care direct costs of CDI to an estimated 4.5 billion € in 2008. The treatment consists of intestinal communities from faeces of healthy donors (Faecal Microbiota Therapy, FMT). However, FMT is not standardized as the contents that are present in the human stool vary from individual to individual and change over time. Moreover, there are safety concerns associated with FMT such as the transmission of the pathogenic microbes from improperly screened and handled stool. FMT is also associated with the need for a healthy donor in every case.FlexiBiome will bring to the market a standardized therapeutic mixture of living intestinal bacteria as an alternative to FMT. Our innovation represents a safe (of a defined composition, clear mode of action), efficient (same functionality as FMT but using a controlled delivery), flexible (production is controlled, the product is storable and we will provide access to large markets) and targeted therapeutic to fight rCDI. Flexibiome will be 50 % cheaper than FMT therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'A IAPP on the Role of NCAM in Stem Cell Differentiation'.

assistant: **Concept**

The STEMCAM project is a 4-years training and transfer of knowledge program between two distinguished academic groups in stem cell research, two highly innovative SMEs and a company leader in development of media for stem cell research, to foster long-term industry-academy collaboration and partnership in the field of stem cells research and applications. The scientific and industrial aim of STEMCAM is to study the role of the Neuronal Cell Adhesion Molecule NCAM and related growth factors in the maintenance, survival and differentiation of induced pluripotent stem (iPS) cells towards the neural and myocardial lineage, in comparison with embryonic stem cells. The project will take advantage of very unique and innovative pharmacological tools, the NCAM and growth factor mimetic peptides discovered by ENKAM. To achieve its aim STEMCAM will apply an interdisciplinary approach from cell biology (including innovative in vitro culture using bi- and three dimensional systems), immunocytochemistry, imaging, molecular biology, electrophysiology, to peptide chemistry and chemioinformatics. The project will run via a training and transfer of knowledge program structured to efficiently exploit the expertise and complementarities between the industrial and academic partners to reach the scientific goals of the project and provide high quality intersectorial training for the participating researchers. This is expected to be of high benefit for their individual career development. The STEMCAM project links intersectorial research activities in two very relevant areas of stem cell research, neurogenesis and cardiomyogenesis and will strictly collaborate with the IAPPs INDUSTEM and PARTNERS and the large FP7 IP ESNATS, complementing and expanding with its unique approach their research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Control of the intestinal flora in poultry for ensuring the products safety for human consumers'.

assistant: **Concept**

European sumers are becoming increasingly cerned over the safety and nutritional quality of their food, which must be free from pathogens and antibiotic residues. At the same time, food production systems must meet sumers cerns for animal welfare, environment and public health, leading to, for instance, rapid changes in poultry nutrition (e.g. ban of in-feed antibiotics) and rearing ditions (e.g. out-door breeding). However, and maybe as a direct sequence, most poultry breeders note at present an increase of the prevalence of digestive troubles among their flocks, linked to digestive bacterial flora dysfunctions. In turn, this could affect the colonisation of the animal intestinal tract by opportunistic bacteria, leading to a degradation of the hygienic quality of animal products meant for human sumption.In fact, there is a lack of data on the effect of the nutritional and rearing changes on the prevalence of food-borne pathogens in poultry production. In other respects, the knowledge of the ecology of the poultry intestinal flora is very poor because of the lack of accurate methodology. Fortunately, novel molecular techniques provide unique opportunities for investigating bacterial diversity.The first objective of this project is to centrate the effort of several European scientists on the study of the effects of the new European regulations and new tendencies in breeding management on the food-borne pathogens (traditional and emerging), in the farm and during the products processing, but also to determine the possible improvements reducing these taminations. The socio-eomic aspects of these changes will be also studied. In parallel, a study of the whole intestinal flora of poultry and of its interaction with the food-borne pathogens will be undertaken, using novel met
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Helicopter Engine Air Intake OPtimization Tool' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The objective of this topic is to set up an industrial and fully automatic optimal design tool, integrating software identified by the Topic Leader, in order to reach TRL6 at the end of the project. This tool has to be dedicated to rotorcraft engine air intake analysis and able to handle multi-objective, multi-parameters and multi-points optimization on a given CATIA CAD.An effective aerodynamic design of the engine air intakes is essential for ensuring a proper air supply to the first stage compressor and thus an efficient behavior of the whole engine installation. However, its optimization has to deal with a lot of requirements and constraints, not always linked to the engine performance itself, but often aiming at improving conflicting criterions. For instance, the engine air intakes design will have some impact as regards the three following different issues:• Volume specifications• Helicopter manufacturer specifications, along with the airframe performance level required• Engine manufacturer specifications, along with the engine performance level requiredIn order to achieve the task, optimization will take into account 3 flight conditions. Among all optimization strategy available, due to CFD solver limited capabilities for adjoint computations, a Surrogate Based Optimization approach is proposed. It allows use of gradient free and global optimization method.Two optimizations are planned during the task: one without Inlet Barrier Filter and a last without. The final objective is to improve flow solution at Air Intake Plane from a distorsion and pressure losses aspect.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Anthropologies of Extortion' (EXTORT) targeting Horizon 2020.

assistant: **Abstract**

Extortion had come to occupy a quintessential position in the global imaginary of mafia-type-criminal organizations. Yet it is also increasingly present beyond clandestine criminal networks and is becoming a normalised profitable source of livelihood and governance and a key visible social relation in many parts of the world. Systematic research on and explanatory models for the apparent expansion and rountinisation of extortion in everyday life (including cyber-extortion) are currently lacking. Timely, the project sets up extortion as an object of anthropological inquiry and charts the first comprehensive cross-cultural account of extortion in social life across South and East Asia, the Americas, Africa and Europe. The proposed program of work consists of 5 main components: 1) Primary research on ‘offers that cannot be refused' across different domains of life in and across 22 settings; 2) Analytical and theoretical development in the study of power, consent and organized crime; 3) Methodological innovation by conducting a simultaneous cross-national ethnographic research and adding a South-to-South comparative angle in an area dominated by single case studies and a focus on the Global North; 4) Capability enhancement by forging an international network of scholars in the emerging field of the anthropology of crime and supporting the careers of the project's 5 Post-docs; 5) Policy relevant research in the fields of violence and consent, organized crime, informal economy and development. The study capitalises on previous research and skills of the PI in the cross-cultural study of bossism, politics and kinship and 'mafias' in the global South. Research will be embedded in anthropology but informed by empirical and analytical questions relevant to criminology, political