RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Open SoC design platform for reuse and integration of IPs'.

assistant: **Concept**

The integration densities offered by nanoscale process technologies enable the development of advanced Systems-on-Chip (SoC).These SoCs are the key building blocks for a broad range of innovative end-products. The complexity of developing advanced SoCs is increasing continuously and development costs are becoming a serious threshold for new product developments. The SPRINT consortium will perform a rigorous integrated research activity to obtain a breakthrough in technology for reuse and integration of IP modules within and across companies, so that IP from various sources can be combined quickly and efficiently.The key SPRINT objectives are:- To align the approaches of the European key players in the SoC domain towards IP reuse and to drive the identification and development of open interface standards for IP integration.- To create an open SoC design platform, consisting of standards and a SoC design methodology, with matching tools and IP modules. Such design platform provides the basis for SoC design environments that support the efficient development and integration of interoperable and reusable IP modules, including debug and verification of SoCs.- To enable European companies to be the first in the world to demonstrate and subsequently exploit the new standards-based SoC design environments in an interoperable way in order to improve on design productivity and the quality in SoC design.The SPRINT project will address a broad range of research topics to establish the paradigm shift that will boost the design productivity and quality of SoC design. The project will be user driven and include concrete design activities for generating detailed requirements and for evaluating the standards and design technology developed. The standards-based open SoC design platform w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Quantum magnetic sensing of neurons using nitrogen-vacancy centers in diamond', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Brain research and quantum technology are at the focus of 21st century science. Although theoretical and experimental studies have provided some insights regarding the mechanisms of how the brain acquires, represents and stores information, a comprehensive theory of the brain and the underlying neural information processing is still missing. Experimental techniques to study brain processes on different levels of description, notably the sub-neuron (synaptic, dendritic and axonal), single neuron and neural network level, are therefore of fundamental importance for brain research. Recently, a new promising technique in solid state physics has emerged for measuring electric and magnetic fields at the nanometer scale with unprecedented spatiotemporal resolution (sub-micron and sub-ms range).  The nitrogen-vacancy (NV) defect in  diamond is a unique ultra-sensitive quantum device that can sense external  magnetic and electrical fields via its spin states,  which can be read-out optically using electron spin resonances. The NEURONQ  project aims towards the development of an NV centre based neuroimaging system for real-time recording of neural activity on the sub-neuron, neuron and neuron network level under ambient conditions. The NEURONQ projects combines both disciplines, brain research and quantum technology, into an exciting multidisciplinary  research  effort by combining expertise from physicists, neuroscientists and nanoengineers. The NEURONQ project is expected to have impact of paramount importance for basic neuroscience research and neurotechnology, and thus, will significantly contribute to European scientific and technological competitiveness and excellency.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Exploring the limits of Fractal Electrodynamics for the future telecomunication technologies', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The aim of this project is basic research on fractal electrodynamics in order to explore the performance limits of highly innovative fractal shaped miniature devices for the future wireless telecommunication systems. This project will: i) explore if fractal devices can reach the fundamental size limit, not reached yet by Euclidean shaped devices, that establishes the smallest size for a given operating bandwidth; ii) assess the viability of such devices in the framework of present technology constraints. The result should be the basis of a new generation of miniature microwave devices such as antennas, filters and resonators. The development of miniature wireless communication sub-systems would remove one of the bottlenecks that prevent the integration of multimedia, communication and remote sensing services in small user terminals, resulting in a significant breakthrough for the Information Society Technologies.OBJECTIVES1- Increase the know-how in Fractal Electrodynamics in order to acquire design guidelines for fractal-shaped antennas and microwave devices;2- Explore if fractal-shaped microwave devices can reach the fundamental miniaturization limit, which has never been reached by Euclidean-shaped devices;3- Develop a software tool for computer simulation of fractal-shaped microwave devices performance, including time domain visualization of the interaction between geometry and electromagnetic fields, in order to allow a physical interpretation of radiation and resonance of the proposed structures. This tool would allow also the later design and optimisation of such devices;4- Explore the impact of the technological limitations on the performance of fractal-shaped microwave devices.DESCRIPTION OF WORKThe aim of this project is basic research on fractal electrodynami
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Commercialization of high-value chemical production in moss' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

TychoBio offers a sustainable alternative to undue use of arable land and petroleum-based processes. In TychoBio we use a green production platform for high-value plant metabolites and grow it in photo-bioreactors. The production platform is based on synthetic biology and genetic engineering of moss. We can provide a competitive alternative to traditional plant metabolite production and reduce current plant metabolite prices as moss requires minimal and cost-effective growth conditions. The platform will target a particular group of high-value plant substances called diterpenoids, which are very difficult and in some cases impossible to produce chemically or biotechnologically on other platforms such as yeast and E. coli. We choose to focus on diterpenoids as they represent a niche of high-value compounds to which moss' properties appear to be superior for the production of these. Diterpenoids are high-value compounds used in food, cosmetics and the pharmaceutical industry. These compounds provide us with a catalogue of hundreds of putative pipeline candidates with various levels of value and accessibility. We have chosen to debut with a diterpenoid called carnosic acid, a potent antioxidant widely used in the industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Rewiring cortical areas through thalamocortical inputs'.

assistant: **Objectives**

Research into neuroplasticity has expanded rapidly over the past ten years and it has revealed the remarkable capacity of environmental inputs to shape both the juvenile and adult brain. Behavioural, electrophysiological and neuroimaging studies in deaf and blind humans have provided convincing evidence that alteration of cortical organization is correlated with enhanced capabilities of the spared modalities. What is the identity of the brain systems that are modified and what are the mechanisms that mediate such changes are major unresolved issues in our understanding of brain plasticity. RECORTHA aims to address this challenge and identify the mechanisms underlying the rewiring of brain connections with a particular focus on the thalamocortical system. We will adopt innovative multidisciplinary approaches (from gene to behaviour) to understand how thalamocortical wiring influences, maintains and ultimately shape the functional architecture of the cortex. Taking advantage of mouse genetics, we will generate new models of cross modal plasticity in which we can directly test the capacity of thalamocortical inputs to restore sensory information. Furthermore, we will determine to what extent this rewiring is triggered by activity dependent mechanisms in the thalamus. These findings will contribute to our understating of how reprogramming of cortical wiring takes place following brain damage that will be essential for efficient functional restoration in sensory disabilities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Insights from within-host dynamics on the coexistence of antibiotic resistant and sensitive pathogens', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Understanding and controlling the evolution of antibiotic resistant strains is one of the biggest public health challenges of our time. Despite a vast amount of data gathered and models being developed, coexistence of antibiotic resistant and sensitive genotypes within the same bacterial pathogen is still an unresolved problem. Simple epidemiological models predict the dominance of either of the two strains while more complex models suffer from generality. Using empirical evidence, I set out to resolve this problem by coupling within-host pathogen dynamics and between-host transmission of bacteria. First, stochastically modelling the within-host system I will develop predictions for the rate of resistance emergence and abundance of sensitive and resistant individuals in hosts with or without antibiotic treatment. While resistant bacteria thrive under antibiotic treatment, the sensitive strain has an advantage in invading and colonising untreated hosts. The outcomes help to get a more detailed understanding of the within-host dynamics, e.g. identification of optimal treatment strategies to confine the evolution of antibiotic resistance. Feeding these results into the dynamics on the population level, the between-host level, will result in a within-between-host feedback. Fitting and confronting the model to empirical data on prevalence and resistance emergence in Streptococcus pneuomoniae and Escherichia coli will conclude this project. The mechanistic implementation of the dynamics can immediately be linked to data which is of great importance given the increasing amount of empirical studies in the field of epidemiology. Through the theoretical and applied results, the study will add new insights and predictions in the field of infectious disease evolution and be able to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evolving Organs-on-Chip from developmental engineering to “mechanical re-evolution”', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

EvOoC aims at developing smart mechanically active Organs-on-Chip platforms as clinically relevant in vitro setups to unravel mechanisms underlying tissue regeneration and progression of unmet diseases.A decade ago, developmental engineering (DE) proposed to model in vitro clinically relevant tissues replica by recapitulation of embryonic developmental events. Despite physical forces have recently been suggested as main driver of developmental processes, mechanical conditioning never prevailed as key DE strategy. This is related to a lack in current in vitro mechanobiology setups, mainly based on open loop systems, which disregard the fact that native mechanical environment varies in time as function of tissue state itself. EvOoC vision is to elevate mechanobiology as leading DE approach through a ground-breaking paradigm, named mechanical re-evolution, based on the high-risk/high-gain hypothesis that an iterative manipulation of mechanical forces is necessary to guide in vitro adult tissue development at unprecedented levels. Towards this vision, I will deliver a new method (Evolving OoC, EvOoC), integrating three enabling functions: “Move” - to apply native-inspired mechanical forces to tissues in vitro; “Sense” – to monitor their comprehensive effect on tissue development; “Adapt” – to modulate forces as a function of tissue responses through machine learning (ML)-based algorithms, towards an unsupervised tissue evolution. I will take advantages of two paradigmatic test-cases (cartilage and heart) to showcase the power of mechanical re-evolution in guiding in vitro tissue physiological and pathological states, towards the identification of a brand-new class of mechanotherapeutics for unmet pathologies.By combining principles of microfabrication, DE, mechanobiology an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Enteric-nervous-system-mediated regulation of intestinal inflammation' (ENTRI).

assistant: **Innovation**

Environmental and internal stimuli are constantly sensed by the body’s two large sensory units, the nervous system and the immune system. Integration of these sensory signals and translation into effector responses are essential for maintaining body homeostasis. While some of the intrinsic pathways of the immune or nervous system have been investigated, how the two sensory interfaces coordinate their responses remains elusive. We have recently investigated neuro-immune interaction at the mucosa of the intestine, which is densely innervated by the enteric nervous system (ENS). Our research has exposed a previously unrecognized pathway used by enteric neurons to shape type 2 immunity at mucosal barriers. Cholinergic enteric neurons produce the neuropeptide Neuromedin U (NMU) to elicit potent activation of type 2 innate lymphoid cells (ILC2s) via Neuromedin U receptor 1, selectively expressed by ILC2s. Interestingly, NMU stimulated protective immunity against the parasite Nippostrongylus brasiliensis but also triggered allergic lung inflammation. Therefore, the NMU-NMUR1 axis provides an excellent opportunity to study how neurons and immune cells interact to regulate immune responses and maintain body homeostasis. We propose to generate and use elegant genetic tools, which will allow us to systematically investigate the consequences of neuro-immune crosstalk at mucosal surfaces in various disease models. These tools will enable us to selectively measure and interfere with neuronal and ILC2 gene expression and function, thereby leading to an unprecedented understanding of how the components of neuro-immune crosstalk contribute to parasite immunity or allergic disease development. Furthermore, we will progress into translational aspects of NMU-regulated immune activation for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Towards the prediction of stratospheric ozone' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The first major objective is to improve the treatments of heterogeneous processes in large-scale models. Models will be used to study periods when heterogeneous processing occurred and for which atmospheric observations are available. Model integrations will be performed including a range of treatments of the heterogeneous processes. The model results will be compared with data to establish the best schemes for microphysics and chemistry to use in the models. In models of the atmosphere run at high spatial resolution, fine filaments of air are a ubiquitous feature around the edge of the polar vortex. It is clear that these filaments predicted by contour advection calculations and high resolution CTMs are indeed real features. That exchange between the polar vortex and middle latitudes, associated with the filaments, does occur is also not in doubt; the task now is to quantify the process and to establish the spatial resolution required in order that models can satisfactorily represent the exchange. A number of model integrations will be carried out to study this issue which is the second major objective of this proposal. Model studies will be carried out using a variety of microphysical heterogeneous schemes, from simple to sophisticated, to understand the requirements for successful forecasting. Model studies will also be carried out, using our 3-D models run at a range of resolutions, to understand the requirements to model accurately the exchange of air between the polar vortex and middle latitudes.To address the issues raised above a combination of models are required which describe the relevant  fundamental microphysical, chemical and transport processes. There are two main elements to the work  programme. These are: (i) the development of improved microphysical co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'IDENTIFYING INHIBITORS OF PROX1 IN COLORECTAL CANCER' (PROX1).

assistant: **Concept**

Colorectal cancer (CRC) is one of the leading causes of cancer related mortality in the developed countries. Interestingly, the host laboratory has recently discovered that the homeobox transcription factor PROX1 is overexpressed in the vast majority of human CRCs as well as in mouse models of intestinal cancer with abnormal beta-catenin/TCF signaling. Furthermore, they provided evidence that PROX1 is regulated by the high concentration of beta-catenin and this regulation seems to be tissue specific. As PROX1 expression was found to be specifically associated with the transition from benign to malignant tumor phenotype and in normal colonic and small intestinal epithelium PROX1 expression is restricted only to some enteroendocrine cells, targeting PROX1 seems to be a novel possibility for anti-CRC drugs. The aim of this proposal is to develop an endodermal cell model for the analysis of PROX1 function in the intestine by using induced pluripotent stem cells, furthermore, to identify inhibitors that regulate PROX1 activity or kill PROX1+ cells in CRC and to validate their effect. To achieve the aims, dominant negative constructs will be generated, the direct target genes of PROX1 will be determined by combining expression and ChIP-on-Chip microarray data, high-throughput chemical library screening will be carried out and the effect of candidates will be validated by using different in vitro and in vivo systems.