RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Remote monitoring strain / extension using novel sensing element'.

assistant: **Innovation**

The goal of this project is to make a microsystem that can measure strain in large industrial plant operating at up to 600 C. The microsystem will detect strain rates as small as 10 8 hr 1. The operation of plant in the power generation, chemical and petrochemical processes and nuclear sectors all require boilers and pipework to operate for long periods at high temperatures in the creep range. At these temperatures, accurate knowledge of the plant condition is needed to ensure safe and reliable operation and to avoid catastrophic creep failure. At present, this knowledge is gained from costly, periodic shut downs and manual inspection. A microsystem which could continuously monitor plant condition would bring about very significant reductions in the cost of operation and maintenance. In the power generation industry alone, an immediate 6% saving on EU wide maintenance costs of 540 MECU would be realized. This would save over 32 MECU per annum. Continuous monitoring is therefore viewed by plant operators as a vital enabling technology necessary to implement modern principles of asset management. The microsystem will be built around a Surface Acoustic Wave (SAW) strain sensor. The sensor will be packaged with integral antennas so that it can be interrogated by a short range RF link, which will reduce installation difficulties. To successfully develop a microsystem like this, a range of expertise is needed and the consortium has been formed with this in mind. The work is divided into ten tasks and these cover the different aspects of the development, namely: provision of SAW crystals; development of the SAW microsensor; packaging the microsystem; development of the RF system; system integration and laboratory tests; and testing on industrial plant. The results will be expl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Engineering electronic quantum coherence and correlations in hybrid nanostructures' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Nanoelectronic devices can provide versatile and relatively simple systems to study complex quantum phenomena under well-controlled, adjustable conditions. Existing technologies enable the fabrication of low-dimensional nanostructures, such as quantum dots (QDs), in which it is possible to add or remove individual electrons, turn on and off interactions, and tune the properties of the confined electronic states, simply by acting on a gate voltage or by applying a magnetic field. The hybrid combination of such nanostructures, having microscopic (atomic-like) quantum properties, with metallic elements, embedding different types of macroscopic electronic properties (due, e.g., to ferromagnetism or superconductivity), can open the door to unprecedented research opportunities. Hybrid nanostructures can serve to explore new device concepts with so far unexploited functionalities and, simultaneously, provide powerful tools to study fundamental aspects of general relevance to condensed-matter physics. Only recently, following progress in nanotechnology, have hybrid nanostructures become accessible to experiments.Here we propose an original approach that takes advantage of recently developed self-assembled QDs grown on Si-based substrates. These QDs have many attractive properties (well-established growth, ease of contacting, etc.). We will integrate single and multiple QDs with normal-metal, superconducting, and ferromagnetic electrodes and explore device concepts such as spin valves, spin pumps, and spin transistors (a long standing challenge). Using these hybrid devices we will study spin-related phenomena such as the dynamics of confined and propagating spin states in different solid-state environments (including superconducting boxes), long-distance spin correlations and en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ELICIT TO LEARN CRUCIAL POST-CRISIS LESSONS' in the context of a Seventh Framework call.

assistant: **Objectives**

The objectives of the call with regard to knowledge gathering, categorisation, analysis and evaluation for the goal of post-crisis lessons learning and use of this learning in practice define implicitly the need of a Community of Practice (CoP) for crisis response. Therefore, the ELITE consortium has a strong representation of experienced crisis managers and responders across all phases of crises and of knowledge management experts embedded within a CoP. The role of the ELITE knowledge management experts is to secure the best acquisition, categorisation, and analysis of tacit, fragmented knowledge acquired by crisis management responders, and to ensure best practice insights. The ELITE CoP is assembled around a web solution comprising a repository of best practices and guidelines as well as social media features (ELITE’s living document). During the project’s lifetime, ELITE uses a holistic method that addresses all relevant phases of major crises along with their systemic relationships. After ELITE’s project period, the living document is targeted as a Wikipedia-like solution with the necessary infrastructure and funding system so as to attract and serve the whole spectrum of end-users and crisis decision makers in Europe. Finally, to promote future research on this topic, ELITE will identify major remaining gaps and deliver recommendations for future research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Understanding the role of B cell phenotypes as a predictor of the efficacy and prognosis of allergen immunotherapy using allergic rhinitis to house dust mite as a model' (PRE-BIT) under Horizon Europe.

assistant: **Objectives**

Allergic rhinitis (AR) is one the more prevalent respiratory allergic disease affecting 20-30% of the global population. The inflammatory process is mediated by eosinophil infiltration and IgE secreted by plasma cells. IgE is a key component in allergies so understanding IgE production and its inhibition is important for treating these diseases. Allergen immunotherapy (AIT) is the only treatment that targets the etiology of allergic diseases. However, the efficacy of the treatment reaches 70-80% in the best scenarios (lower for food allergy), it has a high cost, and most important, prediction of the effectiveness of the treatment is not possible with actual biomarkers. In this proposal the candidate seeks to better understand the phenotypes of B cells, key cells implicated in allergy that are modified with AIT. The knowledge generated by this study will provide biomarkers of AIT prognosis and even predict the outcome of the therapy by analyzing the B cell compartment in patients candidate for AIT.Using very innovative approaches, we will analyze the B cell repertoire involved in the resolution of AR through AIT. B cell repertoire will be analyzed in bulk before and after AIT. In addition, antigen specific B cells will be immortalized so the antibody sequence as well as reactivity can be studied.  Moreover, we will perform an ex vivo class switch assay that could potentially predict the outcome of AIT using cytokine microenvironments like those produced by the therapy and or the pathogenic situations. B cell switching from IgD/M or IgG1 to IgG2/4 appears to be a critical step in the effectiveness in AIT because IgE memory resides in the IgG compartment.  We will use AR to house dust mite patients as a model as it is one of the most prevalent allergic diseases.


**Keywor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Fabrication of novel Heterophase ta-C:Me Nanocomposite Coatings for biomedical applications', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

As the average age of us "European nationals" increases, the demand for major joint replacements is expected to rise in accordance. Although implants are considered an excellent solution to many health problems, any time a medical device is implanted in to one's body there is a high risk for infection not only in the short but in the medium term as well. Additionally, the long-term wear behaviour of the surfaces in contact significantly affects the life of implants. In this manner, there is a need for new multifunctional coatings. In comparison with other implant materials, tetrahedral amorphous carbon (ta-C) has excellent blood and tissue biocompatibilities and therefore many artificial joints and cardiovascular implants are being coated today with ta-C materials. Recent studies have shown the possibility of incorporating certain toxic elements (e.g. Cu, Ag, or V) into hard carbon coatings with the idea of providing the implants with necessary infection resistance.However, until now, these coatings could only be deposited either by hybrid pulsed laser deposition (PLD) techniques or by multi-step processes, making their manufacturing expensive and unrealistic. We propose to investigate the development, the mechanical properties and wear behaviour of heterophase ta-C: Me nanocomposite coatings deposited from two pulsed cathodic arc (PCA) plasma sources.One of the advantages of this novel deposition method over hybrid PLD techniques is its potential application to large surface areas and a comparatively less expensive technology while producing an intense highly ionised plasma plume which is necessary for the deposition of the hard ta-C phase. After the deposition, glow discharge optical emission spectroscopy (GDOES) will be used to obtain a quick analysis of t he homogen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Developing the methodology for a coordinated approach to the clustering, monitoring and evaluation of results of actions under the Ports of the Future topic' (DocksTheFuture).

assistant: **Innovation**

The EU maritime transport constitutes a crucial link in the global logistic chains and plays a leading role in international freight transport. Serving 40% of the EU’s internal trade and 75% of its external trade, maritime transport is an essential element in supporting Europe in maintaining its Number 1 position in global trade. Therefore, as a key node of the EU’s TEN-T ports have the ultimate objective to fully integrate maritime transport into the global logistics chain. Within this framework, DocksTheFuture aims at defining the vision for the ports of the future in 2030, covering all specific issues that could define this concept including among others, dredging, emission reduction, energy transition, electrification, smart grids, port-city interface and the use of renewable energy management.The proposal already addressed a preliminary research on the Port of Future concept, the definition of several Port of the Future topics to be addressed and their related targets in 2030 and a preliminary list of projects that could be potentially clustered together with the RIA retained proposals. Moving from this point, DockTheFuture will:- refine and tune the Port of Future concepts, the Port of the Future topics and their related targets in 2030 and the list of projects to be clustered together with the RIA retained proposals, - identify appropriate KPIs and relevant monitoring and evaluation of results of actions- leading to the a Port of the Future Road Map for 2030 that will include a number of exploitation elements such as tools for evaluation and transferability of Port of the Future solutions, R&D and policy recommendations, training packages and the creation of a Port of the Future Network of ExcellenceAll of these elements will be supported by a comprehensive Disse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Artificial Intelligence meets Material Genome: intelligent design of new MOFs for xylene separation challenge.' (XYMOF) under Horizon 2020.

assistant: **Objectives**

Chemical separation technologies consume 15% of the global energy. Separation of xylene, a common chemical produced on an enormous scale, is one of the most difficult cases, due to very similar physical properties of xylene isomers. This project will address this challenge by identifying an adsorptive material with superior selectivity towards the desired isomer, compared to the current state-of-the-art adsorbents. A very selective material, used as a membrane or in the adsorption unit, would make a step-change in the xylene separation technologies and lead to significant energy savings. To achieve this overall objective, I put together a novel computational strategy by combining molecular simulations, data analysis and AI methods. Using this strategy, I will mine tens and hundreds of thousands of real and hypothetical materials that already exist within the Material Genome, a global space of possible materials and their features. The focus of the project will be on Metal-Organic frameworks (MOFs) since they already show a particular promise for difficult separations. Specific scientific objectives of the project aim to i) understand what MOFs are promising for xylene separations ii) what structural features of MOFs are responsible for their specific behaviour iii) and then, using the AI models, design MOFs with superior xylene separation performance. The progress will be enabled by i) an outstanding research environment of the host group, Prof. Sarkisov, and the infrastructure of the University of Manchester; ii) interdisciplinary and intersectoral collaborations with the leading academics and companies (Prof. Goodwin, University of Oxford, Dr. Pullumbi, Air Liquide); iii) excellent training and professional development opportunities.Together, the environment of the fe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Intra Erythrocyte  Dexamethasone  in  the  treatment  of  Ataxia Telangiectasia' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The main objective of the project is to provide a treatment of the neurological symptoms of patients with Ataxia Telangiectasia (AT), a rare progressively disabling and life-shortening genetic disease for which no therapy is currently available. To achieve this, a pivotal Phase III study will be conducted, to allow regulatory filing to obtain market authorization in EU and USA by 2019. EryDex is an innovative product, developed by EryDel, used to administer dexamethasone sodium phosphate by ex-vivo encapsulation in autologous erythrocytes, which are infused into the patient. EryDex provides long-term delivery of low doses of dexamethasone without the typical steroid side effects and has reached a successful Phase II trial conducted in AT patients. The phase III trial will be an international, multi-center, 1 year, randomized, prospective, double-blind, placebo-controlled, designed to assess the effect of 2 dose ranges of EryDex, administered monthly by IV infusion, on neurological symptoms of AT patients. The protocol of the trial and the regulatory path to registration has already been agreed upon with EMA and FDA.An international patient registry will also be set with the aim of establishing and maintaining a comprehensive clinical database of patients with AT and closely related conditions, enabling the monitoring of AT epidemiology, the development of an evidence-based natural history of the condition, identification of biomarkers as well as development of clinical guidelines.The AT NEST, the first scale to assess symptoms specific to AT patients, coordinated by the AT centre at the John’s Hopkins University, will be tested in the study and if validated will represent the 1st scale assessing chief areas of impairment specific to AT. In parallel to the clinical trial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'STRUCTURE AND FUNCTION of PROTEINS INVOLVED IN SKELETAL MUSCLE EXCI TATION-CONTRACTION coupling'.

assistant: **Objectives**

The eight research groups have established a wide spectrum of modern of skeletal muscle. Action potentials spreading along the transverse techniques such as i) biochemical identification and purification of proteins, ii) cloning, sequencing, site directed mutagenesis, and tubular membrane into the cell interior cause a conformational change of expression of genes, iii) immunocytochemical identification of proteins, the voltage-sensitive dihydropyridine receptors (DHPR) embedded in this iv) ultrastructural localisation of proteins, v) functional membrane. It is by a complex and not yet understood process that activated characterisation of proteins in pharmacological binding assays, vi) DHPR triggers the release of Ca2+ from internal Ca2+ stores, the characterisation of heterologously expressed or reconstituted channel sarcoplasmic reticulum (SR). Ca2+ is conducted by the ryanodine receptor (RyR) situated in the SR membrane into the cytoplasma where it activates proteins by patch and bilayer clamping. the contractile apparatus. More than 10 proteins associated with DHPR and RyR, such as triadin, FKBP12, calsequestrin and several not yet identified proteins are required for functional EC coupling. Here, eight experienced research groups will employ an integrated and multi-disciplinary approach to characterise known and novel proteins of the DHPR/RyR complex and their relationships. The major objective comprises the expression of normal and recombinant known proteins, the identification, isolation and expression of novel proteins, and the analysis of their interactions at structural and functional levels. This project will significantly advance our understanding of the role of the proteins involved in EC coupling.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'INnovation for TERitorial CohEsion around Soil Health' in the context of a Horizon Europe call.

assistant: **Objectives**

The Apulia Region is renowned for its diverse agricultural output, a fundamental element of its economy. However, climate change poses significant threats to the health of soils, due to diverse degradation factors, water scarcity, and non-sustainable land management practices.The depletion of water resources, the prolonged droughts, and deficiencies in soil nutrients threaten the region's agricultural productivity, its biodiversity, and its overall environmental sustainability. Addressing these issues requires a systemic approach through collaborative, transdisciplinary research with practical, on-the-ground involvement of stakeholders (farmers, land managers, local administrators). The University of Foggia (UNIFG), is ideally positioned to lead innovation activities to co-design an innovative model for soil health enhancement at regional level, in collaboration with farmers, land managers, policy makers, and civil society organizations.The project will combine different solutions, to be tested with the support of international leading partners, at a scale that is representative of the regional dimension and characteristic of most geographical regions of Mediterranean Europe. In particular, the project will develop experimental actions using Nature Based Solutions (with the support of FC.ID from Portugal), developing short supply chains for high potential biofertilisers (with local industrial partners), cutting edge precision fertigation systems (with Ugent) and a digital dashboard to enhance data-driven soil policies based on scientific evidence.The project will reinforce UNIFG’s positioning as a leading knowledge institution in rural economies and agrarian sciences, as well as contributing to sustainable regional soil health policies in the framework of the new Europe