RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Use of newly designed organic molecules as large and efficient structure directing agents for the synthesis of microporous aluminophosphates' (NEWSDASFORALPOS).

assistant: **Concept**

We aim to develop new large and efficient structure directing agents (SDAs) for the specific synthesis of microporous aluminophosphates (AlPOs). New concepts will be used for designing new types of SDAs in a search for extra-large-pore microporous aluminophosphates, in line with the search for tailored materials proposed in the Work Programme. AlPOs have unique chemical properties that differentiate them from their zeolite counterparts, remarkably a high hydrophilic nature. We will explore the chemical uniqueness of these AlPO networks in a search for SDAs specifically designed for this type of materials.Three different concepts will be investigated. First, we will explore supramolecular chemistry issues in order to get extra-large SDAs. We will use molecules bearing large aromatic moieties, which are able to self-assemble through π-π type interacions, and thus will form larger molecular entities that will act as SDAs. We will then introduce fluorine atoms in those aromatic rings in an attempt to enhance the molecular aggregation, since it is known that organic F atoms tend to aggregate by developing non-bonded F---F interactions in aqueous media. Second, N-containing molecules bearing hydrophilic groups, such as hydroxyl substituents, will be used in an attempt to maximise the interaction with the hydrophilic AlPO network in order to enhance the structure directing ability of the SDAs. An interesting example of this type of SDAs will be provided by the use of aminosugars, which contain an amino group, required for providing a basic character, and many outermost hydroxyl groups that will potentially enhance the interaction with the hydrophilic framework. Once understood these concepts, they will be combined in order to get large (through aggregation) and efficient (thro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Targeting the transcriptional landscape in infant AML' (2014-2020).

assistant: **Concept**

Infant acute myeloid leukemia (AML) has a dismal prognosis, with a high prevalence of unfavorable features and increased susceptibility to therapy-related toxicities, highlighting the need for innovative treatment approaches. Despite the discovery of an enormous number and diversity of transcriptional products arising from the previously presumed wastelands of the non-protein-coding genome, our knowledge of non-coding RNAs is far from being incorporated into standards of AML diagnosis and treatment. I hypothesize that the highly developmental stage- and cell-specific expression of long non-coding RNAs shapes a chromatin and transcriptional landscape in fetal hematopoietic stem cells that renders them permissive towards transformation. I predict this landscape to synergize with particular oncogenes that are otherwise not oncogenic in adult cells, by providing a fertile transcriptional background for establishing and maintaining oncogenic programs. Therefore, the non-coding transcriptome, inherited from the fetal cell of origin, may reflect a previously unrecognized Achilles heel of infant AML, which I will identify with my expertise to understand and edit the AML genome and transcriptome.I will apply recent breakthroughs from various research areas to i) create a comprehensive transcriptomic atlas of infant AML and fetal stem cells, ii) define aberrant or fetal stage-specific non-coding RNAs that drive leukemia progression, and iii) resolve their features to probe the oncogenic interactome. After iv) establishing a biobank of patient-derived xenografts, I will v) evaluate preclinical RNA-centered therapeutic interventions to overcome current obstacles in the treatment of infant AML. Targeting the vulnerable fetal stage-specific background of infant AML inherited from the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'In situ manufactured carbon-thermoplast curved stiffened panel' (INSCAPE).

assistant: **Concept**

INSCAPE (In situ manufactured carbon-thermoplast curved stiffened panel) main objective is to enhance the automated thermoplastic fiber placement process and machine to manufacture an in situ consolidated double-curved structure including in situ joining of stiffener and skin laminate.Taking the state-of-the-art into consideration, the proposed project will focus on using and enhancing the possibilities and advantages of automated thermoplastic Automated Fiber Placement (TP AFP) to create an efficient process to manufacture complex carbon fiber reinforced thermoplastic aerospace structures.  The sensitivity of the process leads to a mandatory 100% automation for reproducible, industrial production.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Predictive coding in social perception: a social neuroscientific approach to study the dynamic social brain' (2007-2013).

assistant: **Innovation**

It is well known that racial stereotypes can influence the way people evaluate and treat people from other racial groups. Recent findings suggest that social knowledge can also directly influence very basic perceptual processes. These findings are in line with computational models that see the brain as a ‘prediction machine’: based on knowledge about the world, the brain attempts to match incoming perceptual information to top-down predictions and expectations. Here, I explore whether stereotype-based social predictions directly alter basic visual perception, and how the brain supports this integration of high-level social predictions with low-level perceptual processes. I propose a series of experiments that use binocular rivalry (in which different pictures are presented to the left and the right eye, which results in only one picture entering consciousness) to test whether stereotype-evoking primes (such as a middle eastern face) can alter how and when socially relevant objects (such as weapons) enter awareness. To explore how the brain supports the dynamic integration of stereotypes with ongoing perceptual processes, I will measure the electrical activity of the brain (the electro-encephalogram or EEG). To chart integration of top-down and bottom-up information across brain wide networks, I will study synchronization over EEG frequency bands associated with these two streams of information. I will employ a novel method of analysing neural data, Granger causality, to test whether oscillatory activation evoked by social primes has a direct causal relation with oscillatory activation related to altered visual awareness. Together, these experiments will elucidate whether basic perception is indeed shaped by social knowledge embedded in stereotypes, and how the brain sup
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Interplay of genetic, nutrient and lifestyle factors on incidence of coronary disease: EPIC-Heart' (EPICHEART).

assistant: **Innovation**

A major new frontier in biomedicine is to identify interactions of specific components of nature and nurture in determining risk of complex diseases. Coronary heart disease (CHD) - the single leading cause of death in Europe - is jointly determined by genetic and lifestyle factors. It is unknown, however, how diet, nutrients, and lifestyle factors modulate genetic susceptibility. For scientific and public health reasons, there is a strategic need to study such interactions reliably. There is a unique opportunity for a cost-effective and powerful study because we have:-conducted detailed assessment of diet and other lifestyle factors in 520K participants in a pan-European prospective study-identified >12K incident CHD cases accrued during >5M person-years at risk-identified a random sub-cohort of >15K participants without CHD to serve as referents-commenced assay of lipid and other markers in 12K cases and 15K referents-prepared DNA for genetic assay.In 12K CHD cases and 15K referents, we will assay: >217K genetic variants contained in the state-of-the-art metabochip; 37 fatty acids; and vitamin D metabolites. Analyses will focus on: discovery of interactions; causal evaluation of biomarkers; CHD risk scores.The findings should open new horizons and contribute towards: 1) explaining missing heritability 2) shaping nutritional guidelines 3) personalising preventive medicine 4) defining approaches to modify genetic susceptibility by avoiding deleterious lifestyles 5) identifying biomarkers that are priority therapeutic targets and 6) innovative prognostic tools.Gene-lifestyle interplay is a major future growth area. This world-leading study will enhance Europes strengths in public health, nutrition and genetic epidemiology, and create a valuable future resource.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Demonstration of innovative, lightweight, 100% recyclable PET prototype formulations and process tooling for low carbon footprint  packaging to replace current industry standard virgin plastics' (ECOPET) under Seventh Framework.

assistant: **Objectives**

The European food packaging sector has a turnover of €6 Billion per year with the production of 200 Billion polymer trays, the vast majority of which are manufactured from virgin non-recyclable plastics such as polypropylene (PP). The plastics packaging thermoforming sector in Europe consists of over 1200 companies employing approx. 150,000 people. In excess of 70% of these jobs thermoforming companies are SMEs. This sector faces very significant competitiveness and environmental sustainability issues, which this project will address. The overall objective of the project is to make Europe the leader in low carbon footprint, high-recycled content and long shelf life polymer packaging.Specifically the ECOPET project will demonstrate the innovative recycled Polyethylene terephthalate (rPET) technology developed in the RPET-FC FP7 project, which will significantly reduce the weight and carbon footprint of packaging. In conjunction with this lightweight material a high barrier polyester will be applied enabling full recyclability of the packaging. In order to further extend shelf life the performance of a natural antioxidant/anti-microbial sub-micron thick coating will be evaluated. The developed technology will replace the use of virgin polypropylene (PP), which is the current market leader in food packaging.  The specific project objectives are to demonstrate:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Geomagnetic field excursions: revealing the extreme states of Earth's outer core' (EXCURSION).

assistant: **Innovation**

EXCURSION resolves around fundamental questions concerning the operational mechanism, causation, and predictability of the most frequent transitional events of the Earth's magnetic field. Geomagnetic excursions are episodes of low field intensity globally with no complete polarity reversals but anomalous magnetic directions that do not reflect a dipolar field. They reduce the shielding against solar and cosmic radiation, thus triggering significant technological and potential environmental and climatic impacts. Our understanding of geomagnetic excursions is severely limited. The urgency to study these events arises from several facts, including the substantial decrease in geomagnetic field strength over the past centuries, certain future events considering the dynamic nature of excursions, and harmful effects on modern technology. To advance in this subject, we must understand the core dynamics and global and regional characteristics of as many of these events as possible. This project focuses on the geomagnetic excursions in the Brunhes Chron (past 780,000 years). I will build the first data-based model of the geomagnetic field over the Brunhes Chron, complemented with high-resolution reconstructions of excursions. These models will be assimilated into state-of-the-art 3D dynamo simulations to infer the excursional state of the core and geodynamo. Furthermore, novel machine learning methods will be applied to the new models to assess past field configurations that resemble the present-day and identify common characteristics and potential precursors of the excursions. This ground-breaking synthesis of multi excursional events analyzed with data-based reconstructions, data assimilation by 3D numerical simulations, and machine learning techniques will create a holistic fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sociocomplexity — new paradigms for understanding complex group-level adaptation' (SOCIOCOMPLEXITY), addressing dissemination and exploitation.

assistant: **Impact**

Natural selection explains the appearance of design in the living world. But at what level is adaptive design expected to manifest (gene, organism or society) and what is its function? Adaptation may manifest at multiple levels, and indeed new levels of adaptive individuality may evolve over time – such as with the emergence of multicellularity and eusociality. However, understanding the forces that drive such “major transitions” remains a challenge: current theory, with its focus on single, simple traits, has been unable to engage with issues of complex, coordinated adaptation at the level of the group, and this has led to a striking mismatch between theory and data. In particular, there is currently very poor understanding of what drives conflicts within groups and how group-level adaptation can sometimes prevail despite these conflicts. My research team will develop new theoretical and in silico experimental paradigms for studying complex, group-level adaptation to resolve these problems. We will: (1) synthesize the theories of inclusive fitness and multilevel selection to allow direct engagement with complex adaptive design at multiple levels of biological organization; (2) take a geometric approach to social adaptation to determine how complex, multidimensional phenotypes evolve in the context of social conflicts; (3) develop a computational paradigm for group-level adaptation in which complexity may be quantified and tracked over evolutionary timescales; and (4) employ genomic imprinting as a tractable model of major transitions, to understand how conflicts of interest arise and how they resolve to maintain or disrupt the adaptive integrity of the organism, with applications to childhood cancers and growth, fertility and neurological disorders. This research will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Diagnosis and Exclusion of Drug-Induced Liver Injury by using Patient Blood Samples (DILITEST)'.

assistant: **Innovation**

Ca. 1 billion USD are lost by late stage failures per one successfully marketed drug. Idiosyncratic Drug induced Liver injury (iDILI) is one of the major causes for late stage failures and also can have serious consequences for the patient like death or the need for liver transplantation. iDILI occurs only in susceptible patients regardless of drug dosage or latency and is not predictable from preclinical in vitro or animal testing. Usually it occurs during late stage clinical phases, when hundreds of millions of USD were already invested in the drug. Therefore, iDILI is a significant challenge for patients, drug-developers and regulatory bodies. Until now there is no valid test available that allows to positively diagnose or exclude a drug as iDILI cause, resulting in incorrect market withdrawals or project terminations. Since the majority of patients would tolerate the drug, these patients are deprived from innovative treatment options. DILITEST aims to develop a test to diagnose iDILI in individual patients and identify the causaltive drug. The test is based on a patented method to generate liver cell-like cells from a blood sample. This will allow to prevent investment losses by incorrect market withdrawals or terminations and solve the dilemma of iDILI for patients, pharmaceutical industry and regulatory bodies by enabling marketing of safe drugs and avoiding incorrect terminations. Overall objective of DILITEST is to market the highly innovative test by MetaHeps GmbH after validation in independent cohorts of european and american registries led by international experts in the field of iDILI research.MetaHeps GmbH will provide the unrivaled technology as a service to pharmaceutical industry with focus on the still growing high volume clinical trial market, allowin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Walls for Freedom? Divided cities in a global age: Padua, Ceuta & Melilla, Belfast and Berlin' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Porous borders and walls seem to be a contradiction in terms, yet they coexist in contemporary societies. This project aims to asses this contradiction by exploring the impact of walls in contemporary European cities. As urban artifacts walls are a contentious figure: not friendly, but embodying security; not totally urban, but defining urbanity and civility; not a common good, but representing the distinctive line between one specific community from another.   By tracing the historical, cultural, socio-political and economic arguments for erecting walls in Padua (2006), Ceuta/Melilla (1998/2001), Belfast (1970’s) and Berlin (1961) this project explores the impact of walls in ordinary city life in a twofold way. On the one hand it questions the effectiveness of walls as an instrument for conflict resolution, while on the other hand it addresses the moral understanding they provoke at the level of institutions and lay persons. By combining approaches and methods of historical and social science research, this project creates the necessary conditions for responding to the main questions it asks how walls shape everyday practices, and how these practices in turn accommodate, legitimate or challenge the presence of walls in each of the selected settings.  Thus, this project aims to study the impact of walls for urban social life and the way in which they are incorporated and absorbed within the daily routines by the inhabitants of the above-mentioned cities. By comparing different historical and spatial contexts/conflicts in which walls have been built, the project is expected to further the understanding, current validity and legitimacy of this archaic urban form in contemporary European societies. This understanding will not only enhance the scholarly fields of urban hist