RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Extracellular vesicle-mediated delivery of long non-coding RNA: Implications for vascular repair and regeneration' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Background: The concept of extracellular vesicles (EVs) has drastically changed from the initial non-functional debris to the current of key mediators of paracrine signalling. The cargoes of EVs comprise all kinds of macromolecules, and recent evidence has demonstrated the presence of long non-coding RNAs (lncRNAs) in such vesicles. These RNA molecules have numerous potential regulatory functions and results obtained so far guide us to presume a determinant role in vascular cell differentiation, proliferation and repair. Besides, the increasing data emerging in the field are significantly changing the way in which we interpret molecular mechanisms driving cardiovascular diseases and offers a brand new set of molecular targets for therapy. For all these reasons, study of lncRNAs in vascular biology and disease is state-of-the-art. Objectives: The main aim of this project is to study extracellular vesicle mediated cell-to-cell communication between human smooth muscle cells and endothelial cells, evaluate its relevance in vascular injury in an in vitro model of pulmonary arterial hypertension, and determine the significance of long non-coding RNA in this crosstalk. Methodology: For imaging EV transfer among vascular cells, we will use a pioneer approach based on Cre-loxP recombination which results in a fluorescent colour switch of cells upon EV uptake. Cells will then be sorted according to fluorescence by flow cytometry and analysed by cutting-edge proteomics and bioinformatics, in order to elucidate intercellular signalling triggered by EV transfer. The lncRNAs present in EVs will be analysed by RNA-Seq. Mechanistic insight of enriched lncRNAs in EVs will be evaluated using gain- and loss-of function approaches in vascular cells using lentiviral vectors and GapmeRs/siR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enriched communication across the lifespan', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Speech is a hugely efficient means of communication: a reduced capacity in listening or speaking creates a significant barrier to social inclusion at all points through the lifespan, in education, work and at home. Hearing aids and speech synthesis can help address this reduced capacity but their use imposes greater listener effort. The fundamental objective of the ETN ""Enriched communication across the lifespan"" (ENRICH) is to modify or augment speech with additional information to make it easier to process. Enrichment aims to reduce the listening burden by minimising cognitive load, while maintaining or improving intelligibility. ENRICH will investigate the relationship between cognitive effort and different forms of natural and synthetic speech. Non-intrusive metrics for listening effort will be developed and used to design modification techniques which result in low-burden speech. The value of various enrichment approaches will be evaluated with individuals and cohorts with typically sub-optimal communication ability, e.g., children, hearing-impaired adults, non-native listeners and individuals engaged in simultaneous tasks. The ENRICH consortium consists of 8 beneficiaries and 7 partners from academia, industry and clinical practice in 9 countries, who collectively provide diverse infrastructure for investigating spoken communication and for applying innovations to end-user populations. ENRICH will address the unmet need for multi-skilled practitioners and engineers in this rapidly growing sector currently facing a serious workforce shortage. Through a comprehensive training programme driven by the needs of industry and clinical practice, it will equip fellows with not just the necessary cross-disciplinary knowledge and research techniques, but also with experien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Wide area research training in health engineering' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The proposed multi-host programme constitutes a step towards structured multi-diciplinary research training in the field of Health Engineering, in particular electronic health, medical imaging, biomedical engineering, and ambient intelligence as applied to prevention, continuous monitoring and care of patients. This field is subjected to strong economic pressure to transform the operating modes of health systems, leading to a real demand. Barriers between areas tend to hinder advances in research and development.Our project aims at training researchers integrating their speciality within a wide perspective. Since a thorough knowledge of the highly multidisciplinary field of Health Engineering is not possible, researchers will focus on a main area, be actively engaged in a project within an additional area closely related to the main area, and gain enough knowledge within the entire programme field to understand its main issues. This approach entails a cross-fertilisation between the many areas involved in the field. Such profile is valuable in both industrial sector and research laboratories. In addition to multi-disciplinarity, our training programme is based on intensive exchanges and collaborations within a social-economic reality.The hosts are in close con tact with hospitals, companies and patients, which lead to continuous evolution and knowledge transfer. Each PhD student will be co-supervised and will stay at least six months in a different host. Moreover, the programme aims to develop skills in group work, communication, and working in an international context. The work is organised into projects to provide PhD's with experience in leading future projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'ICT Standardisation Observatory and Support Facility in Europe' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

StandICT.eu 2029 builds on the success of the previous three editions [2023-26, 2020-23, & 2018-19], delivered by the original partners who designed the previous editions, considered in Europe as the “go-to project” on ICT Standards in Europe. Its principal goal is to strengthen its global reach in the EU ICT Standardisation Ecosystem, by: a) managing a neutral and efficient facility supporting a Fellowship Programme with € 4.2M funding in 36 months & 6 Open Calls; b) delivering ICT standardisation landscape & gap analysis via Technical Working Groups, empowering contributions from ICT standardisation experts. Timely standards updated in the EUOS EU Observatory for ICT Standardisation; c) delivering a mentoring & coaching programme for the next generation of ICT standardisation experts, SMEs & researchers with SDOs, EU & national funded R&I projects & engage directly with a subcontract signed with the ESOs: ETSI & CEN & CENELEC; d) Providing a forum for foresight analysis to guarantee high-level steering with an authoritative Foresight Committee Board FCB supported by funded fellows active in SDOs, early-warning signals in-synch with the MSP, ICT Rolling Plan & High-level Standardisation Forum; e) Organising and support standardisation meetings of SDOs, global fora & consortia so Europeans, and SMEs, may participate easily.Consortium: Trust-IT Services (IT, coordinator), COMMpla (IT), Dublin City University (IE), Open Forum Europe (BE), AUSTRALO (ES), Digital SME Alliance (BE), Fraunhofer Institute for Systems & Innovation Research ISI (DE).Outputs: Fellowship Programme, 1200+ proposals, 300+ European Experts Funded & 70+ External Evaluators; 4,000+ metadata of ICT Standards in the Observatory; 20+ Webinars, 3 Mentorship Events, Training Lectures, 2 Impact Events & Repo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Stapled peptide analogues as inhibitors of the CCR4-NOT complex to regulate the mRNA degradation' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

RNA has gained significant attention in the past few decades due to its evolutionary role in gene regulations. In the regulation process RNA seldom works as an individual entity rather associated with several protein-protein complexes (PPCs) and those complexes play a key role in mRNA maturation. Typically, mRNA undergoes different post-transcriptional modifications and deadenylation is one of those post-transcriptional events in which shortening of the poly(A) tail at the 3 end of mRNA occurs and it plays a major role in mRNA stability. Deadenylation is often regulated by different PPCs and dysregulation of these complexes severely impaired this process. In fact, in many cancer cells shortening of poly(A) tail has been found due to the non-specific deadenylation event. Therefore, Chemical modulators that can regulate the deadenylation process have immense therapeutic importance. CCR4-NOT is one of the most studied deadenylase complexes which actively participate in the deadenylation process. Several types of mRNA-associated proteins (NOT4, Bam, and Roquin) are known which recruit RNA to the CCR4-NOT complex for deadenylation by interacting with CAF40 through its evolutionary conserved site CAF40 binding motif (CBM) domain. Moreover mRNA-associated proteins and RNA both share the same binding surface of the CAF40 protein. Therefore, blocking the interaction between CAF40 and RNA would serve the inhibitory activity of the CCR4-NOT complex towards the deadenylation process. From crystal structure, it has been found that the CBM domain of Bam protein interacts with the CAF40 protein through its -helical surface. Here in this proposal, we will design -helical hydrocarbon stapled peptide analogues of CBM domain to exploit the protein-RNA interaction by regulating the activit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advanced diagnostics of parasitic diseases' to be submitted under Sixth Framework.

assistant: **Abstract**

The project entitled Advanced diagnostics of Parasitic Diseases" is a transfer of Knowledge, development scheme action. The goal of the project is to implement advanced diagnostic techniques such as: DNA based assays and serological assays in the W. Stefa nski Institute of Parasitology of the Polish Academy of Sciences.The Institute is a unique parasitological establishment which conducts multi- and interdisciplinary research in the field of medical and veterinary parasitology. The objective of the project is to develop a new area of competence in the field of diagnostics and as a result create a Diagnostic Reference Centre cohesive with European policies. This will be achieved through the recruitment of experienced and more experienced researchers which pos ess a high level of expertise in the area of research. The knowledge transfer will be further realised through the secondments of the Institute's experienced researchers to leading parasitological partner organisations in France, Sweden and Italy. Further objectives of the project are connected with the integration of our facility into the European Research Area. They involve the unification of research methods and practices, developing international PhD studies and training of staff in partner finding, est ablishing cooperation as well as writing and managing research projects.The project is envisaged to increase the national and international competitiveness of the Institute, contribute to building European research potential and have a profound, long-lasti ng influence on the scientific developmentof the establishment."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Responsible Space Growth: Sustainability Resilience and Competitiveness for the Emerging Low Earth Orbit (LEO) Economy' to be submitted under Horizon Europe.

assistant: **Abstract**

Humanity is presently at the brink of a new era in space development likely to irreversibly bind our daily lives to assets in orbit and beyond. Starting from the paradigm of 6G wireless networks that in the next decade will release cellular services from spaceborne base stations, a diverse range of sectors including energy, materials, nano, bio and pharma will extend activities into LEO orbit. Space is thus evolving into an ever-greater strategic priority for the European society, economy, security and sovereignty. Despite World-class capacities that Europe enjoys, present trends present substantial threats for the future. Current practice poses unviable burden on the terrestrial and orbital environments. Competition from established and emerging players threatens the European position, whilst ease of access is turning space into an increasingly contested domain. The vision of SPARE is to underpin Responsible Growth for space along three interconnected innovation objectives: - Sustainability: ensure space uses natural resources responsibly across terrestrial & orbital environments- Resilience: embed in space systems security, safety & robustness against technical failures and malicious acts- Competitiveness: create value proposition amid fast evolving industry, market & regulatory landscapes Adopting a broad perspective where engineering and technological innovation are intimately linked with the environment, regulation and the economy, SPARE delivers a World-class training programme addressing critical bottlenecks along the pathways to sustainable and resilient growth of the European space sector.


**Keywords:** sustainable space, low earth orbit, responsible space
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Europe's Transformation: Where People Matter' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The project will organise the presidency event (conference) “Europe’s Transfomation: Where People Matter” in Vienna, Austria, November 2018.    It encompasses the operational and strategic work required to host this event, including Innovation and Content Management (e.g. collaboration with stakeholders to jointly design the conference programme); the Conference Logistics (e.g. organising a venue and the registration process); and Dissemination and Exploitation of the conference outcomes (e.g. setting up a conference website and collaborating with media).    With regard to the wider context of the UN's Sustainable Development Goals, the overall aim of the conference is to foster an improved synergy between pertinent initiatives launched by the Commission and by the Member States, to the benefit of the overall coherence of actions within the field of research and innovation in the areas covered by Societal Challenge 5.


**Keywords:** Presidency Event, Sustainability, Environment, Stakeholders, Development, SDGs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Hindcast of dynamic processes of the ocean and coastal areas of europe' (HIPOCAS).

assistant: **Concept**

Problem to be solved:Collection of long-term information on prevailing environmental conditions to assess the climate and plan the sustainable development of economic activities in European waters.Scientific objectives and approach:The objective is to obtain a 40-year hindcast of wind, wave, sea-level and current climatology for European waters and coastal seas for application in coastal and environmental decision processes. The initial work is to produce the atmospheric data that will serve as forcing to the circulation and wave models. To describe the small-scale atmospheric response three regional climate models will be forced with the large scale 40 years NCEP-reanalysis. The data are provided on a 50 x 50 km grid and will be used in the project to force the wave and ocean models.Circulation models will be used in the North Sea, the North East Atlantic south of UK, including Azores and Canary Islands, and the Mediterranean sea. Wave models will be used in those areas and also in the Irish Sea. The predictions will be made with a typical horizontal resolution of 10km and temporal resolution of 3 hours. The wave models that will be used in the project are based on the last version of WAM, which will be used with nested grids in order to produce high-resolution information in coastal waters. In the North Sea this model will take into account tidal changes that will influence wave predictions. Altimeter data from ERS1, ERS2 and Topex-Poseidon will be sorted in order to collect the available remotely sensed data including wind, wave, sea-level, storm surge and ice-sea measurements for same areas for which hindcasts are being made.Whenever the hindcast and remote sensed data are available they will be compared in order to assess the level of uncertainty involved in using
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Engineered Nanomaterials as Adjuvants to Boost Neuroblastoma Vaccine Efficacy' under Horizon Europe.

assistant: **Concept**

Neuroblastoma (NB) is a rare, aggressive malignancy primarily affecting children under the age of 5. Despite significant advancements in treating NB, the disease remains a formidable challenge. A promising approach for NB treatment is the development of therapeutic cancer vaccines with innovative nanomaterial-based adjuvants. When used as adjuvants, nanomaterials offer several advantages, including efficient migration to lymph nodes, improved antigen presentation by dendritic cells, and cross-presentation to cytotoxic T cells. Numerous ongoing clinical trials for NB vaccines are investigating the combination of multiple adjuvants to enhance immune responses against target antigens. NANO-ADJUVANT focuses on developing innovative nanomaterial-based adjuvants, incorporating immune-stimulating elements to enhance anti-tumor immune responses. Using my expertise in nanomaterial formulations, I will develop novel selenium-based nanoparticles incorporating manganese and zinc. These nano-adjuvants will be designed to elicit balanced antibody and cell-mediated immune responses when combined with tumour-associated peptides. Mentor, Dr Piskareva’s experience in NB will be utilised for in vitro and in vivo studies to assess vaccine efficacy. During a secondment to Vall d’Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Spain, I will perform the preclinical evaluation of vaccine efficacy in a NB mouse model under the guidance of Dr Segura. To characterise anti-tumour immune response at the molecular and cellular level, I will use the expertise of Centre for Systems Medicine (CSM) in my host institution (RCSI) by performing scRNA-seq and bioinformatics analysis. NANO-ADJUVANT aligns with Europe's Beating Cancer Plan, which prioritises improving outcomes for childre