RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Force production of myosin 18 and its molecular sociology with myosin 2'.

assistant: **Innovation**

The cytoskeleton is a complex protein web organised through the cell to provide structure and cell shape dynamics. One critical and often overlooked component is Myo18, which is part of the myosin superfamily of motor proteins. By interacting with actin, myosins canonically produce force through a series of conformational changes driven by the hydrolysis of ATP. However, Myo18 appears not to cycle through the set of conformations found for other myosins due to its divergent sequence. It is therefore hypothesised to act as an actin cross-linker rather than actively producing force. Another myosin family, Myo2, is the most prominent force producing component in the muscle sarcomere and in stress fibres which drive cell migration. Myo2 performs its role by forming filaments through a coiled coil domain creating a structure with multiple force producing heads ready to bind and move along actin. The coiled coil of Myo18 allows recruitment into Myo2 filaments within these niches but its role is obscure given its divergent behaviour. The sociology between these two myosin families, that is the specific interactions of different partners in space and time, is interesting given the complementary features of these two protein families. This study aims to structurally characterise Myo18 in different nucleotide states on and off actin to gain insights into the evolution and function of its cryptic cycle. Furthermore, this work will assess through structural characterisation how Myo18 and Myo2 directly interact through their coiled coil domains. This association will then be analysed through biophysical studies exploring how Myo18 alters force production and function by intercalating into Myo2 filaments.


**Keywords:** cytoskeleton myosin Myo18 Myo2 stress-fibres sarcomere motors a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Fulfilling the Potential of Globular Clusters as Tracers of Cosmological Mass Assembly' (Multi-Pop) under Horizon 2020.

assistant: **Objectives**

Globular clusters (GCs) are among the oldest luminous sources in the universe, bearing witness to theearliest stages of galaxy formation as well as their evolution to the present day. While GCs have played apivotal role in our understanding of the assembly of galaxies, their full potential remains unfulfilled due toour lack of understanding of how they form. One of the largest stumbling blocks has been the anomalouschemistry (both metallicity distributions and abundance patterns) of GCs relative to field stars within galaxy.Here, we will turn the problem around and exploit these differences to understand the co-evolution of GCsand their host galaxies.Our understanding of GCs and their formation has undergone a radical change in the past two decades. First,it is now clear that while traditionally thought of as the quintessential simple stellar populations (i.e., all starswithin a cluster have the same chemical abundances and age), globular clusters host multiple stellarpopulations with spreads in He, many light elements (e.g., Na, O, Al) and even Fe in a few cases. Secondly,GCs, once thought to only be able to form in the special conditions present in the early Universe, are nowknown to be still forming today (known as Young Massive Clusters - YMCS). These two facts have openedup a new window into the interconnectedness of GC and galaxy formation and co-evolution.In this project we will quantitatively test current GC formation models with observations of YMCs, as wellas organise what is known of the stellar populations within GCs (e.g., abundance spreads, CMDmorphologies), providing, for the first time, a global view (i.e., which characteristics are specific toindividual GCs and which are common to all GCs). These results, when combined with what is known aboutmassive cl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PARticle Systems: Training on DEM simulation for industrial and scientific applications' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The overarching aim of the PARDEM project is to provide high quality training to a group of young researchers to work within and to further develop the multidisciplinary field of DEM computational simulation of granular processes. Granular materials are estimated to constitute over 75% of all raw material feedstock to industry. They also present many challenges for innovation and fundamental science to solve problems in areas as diverse as natural disasters and industrial material handling which incur extensive economic losses. The Discrete Element Method (DEM) is a promising supradisciplinary facility providing both visual and quantitative details of the dynamics of particle assemblies. Although the method is established in academia, immature quantitative prediction capabilities and lack of DEM experts due to its rapid development hinder its use as an industrial engineering tool in Europe. To overcome this state a consortium of 6 industry and 5 academic partners is formed which engages the three key stakeholder groups (industrial users, DEM software developers and universities), vital for transforming DEM from a largely scientific tool into a widely adopted industrial tool and delivering increased competitiveness to the EU economy with significantly reduced development times of more efficient processes. The programme will provide for each fellow: a) in-depth training by research at the host site and on industrial secondments; b) sound multidisciplinary and intersectoral scientific training and understanding of industrial environments via courses and secondments; c) a programme of complementary skills training and network events to develop the researchers competencies and career options. The resulting new generation of DEM experts will speak a common language avoiding c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'MObiLIty sERvices Enhanced by GALILEO & Blockchain'.

assistant: **Innovation**

MOLIERE - ""MObiLIty sERvices Enhanced by GALILEO & Blockchain"" will build the world's best open data commons for mobility services, the “Wikipedia of public transport and new mobility data”, a Mobility Data Marketplace (MDM) underpinned by blockchain technology, raising the profile, visibility, availability, and utility of geo-location data from GALILEO, and will test it to fuel and demonstrate a diverse set of concrete, highly relevant mobility scenarios and use cases where geo-location data is key, addressing the needs of cities, public transport authorities, mobility service providers, and end-users.""


**Keywords:** GALILEO,  geo-location,  MaaS,  Data-Sharing,  Open-Data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'First insight into endolysin mediated lysis in the wine microbiota'.

assistant: **Objectives**

Grapes are the largest fruit crop worldwide and in 2023, 15.9 billion litres of wine was produced in the European Union alone. Many challenges exist in the process of converting grapes into wine, including those associated with the resident wine microbiota. This microbiota consists of several micro-organisms, including Oenococcus oeni and a variety of other lactic acid bacteria. Some members, such as O. oeni, contribute mainly positively to the final product. However, there are certain species that are responsible for organoleptic defects. Therefore, protection measures are in place to target spoiling bacteria, of which the use of sulphites is one of the most common tactics. As reduction of chemical preservatives is a relevant theme in recent years, the search for alternatives is ongoing. Microbial-based alternatives are increasingly attractive and meet the demands for chemical-free food products. One such promising alternative involves the use of endolysins, which are phage-encoded hydrolytic enzymes used by phages to degrade the peptidoglycan layer of the host bacterium at the end of their lytic replication cycle. ENDOWINE will strive to exploit phage-derived endolysins as antimicrobials in wine. With rapid activity and high specificity among the many reasons, endolysins are particularly promising. Very few experiments using endolysins in food products have been performed, but their potential has already been demonstrated in the medical and veterinary setting. Furthermore, egg white lysozyme is already applied by the wine industry.Using a multidisciplinary approach, we will first determine the diversity of endolysins in phages infecting wine LAB through in silico analysis. Candidate endolysins will be chosen, cloned, overexpressed and purified in Escherichia coli, aft
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Impact of Immigration on HIV and Tuberculosis Epidemiology on the Mediterranean area'.

assistant: **Concept**

The nature of immigration to the EU has changed dramatically over the last decade, often as a direct consequence of the processes of globalisation. Immigration from subsaharian area and from outside Africa will bring new threats from communicable disease to the health system in European and North Africa countries that are along the border with the Mediterranean Sea especially Spain in the North and Morocco in the South.The specific objectives of the proposal SSA is to develop the capacity of the countries involved in this project as a consortium to (Morocco and Spain) survey tuberculosis and HIV disease transmitted through subsaharian and other immigrations. To meet the objectives, the project proposes to hold 2 workshops to bring together the consortium members accompanied by stakeholders delegates of international and national NGO concerned with the process, representatives of health programmes, researchers from universities of Medicine, delegates of United Nations Agencies and others decisions makers.The workshops aims to review- the surveillance and epidemiologic issues and the laboratory diagnosis concerning tuberculosis and HIV/AIDS disease considering immigration factor,- the ethical issues related to health for immigrant population.- the specific requirements to take into consideration for improving the epidemiologic surveillance of HIV and tuberculosis diseases in immigrant population.The workshops outcomes will be published and disseminated through a methodology book and guidelines. At the end, a large cooperation project related to immigration and communicable diseases in Mediterranean area will be completed for European Commission support (FP7).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Emergence of novel phenotypes  in co-evolving biological systems:  allelic diversification and dominance  at the Self-incompatibility locus in Arabidopsis.' (NOVEL) under Horizon 2020.

assistant: **Objectives**

The emerging field of systems biology is revealing the intricate nature of biological organisms, whereby a large fraction of their individual components (genes, proteins, regulatory elements) interact with several others. The co-evolutionary processes that this entails raises the question of how phenotypic novelty may arise in the course of evolution, since all parts of the system have to evolve in a coordinated manner if the phenotype is to remain functional. For most biological systems, however, we are lacking even basic insight into the fine-scale mechanistic constraints and the underlying ecological context. In this project, we will focus on the sporophytic self-incompatibility system in outcrossing Arabidopsis species, a model biological system in which two distinct co-evolutionary processes are becoming well-understood: 1) between the male and female reproductive proteins allowing self-pollen recognition and rejection and 2) between small non-coding RNAs and their target sites that jointly control the dominance/recessivity interactions between self-incompatibility alleles. By studying these two model systems, we will aim to catch the emergence of functional and regulatory novelty in flagrante delicto. We will take a multidisciplinary approach combining theoretical and empirical population genetics, evolutionary genomics and ancestral protein resurrection using transgenic plants. Our goal is threefold: 1) decrypt the molecular alphabet of the interaction between co-evolving nucleotide sequences, 2) predict and evaluate the fitness landscapes upon which the two co-evolutionary processes are taking place and 3) exploit natural variation in closely related species to unveil the kind of co-evolutionary process in natural populations. Our combination of various powerful
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Entanglement and the foundations of quantum information' (ENFOQI).

assistant: **Concept**

The research in this project concerns different aspects of quantum entanglement and the foundations of quantum mechanics. On the morepractical side, we will study the structure of multiparticle quantum correlations and how state analysis in experiments can be performed.On the fundamental side, we will investigate non-local hidden variable models and study possible applications of quantum contextuality.The Marie Curie Career Integration Grant will help to build up a strong research group in quantum information theory at the University of Siegen.The grant shall mainly be used to build up international collaborations via mutual visits and to organize workshops in Siegen on the topics of the proposal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DEVELOPERS OF CIRCULAR SOLUTIONS' under Horizon Europe.

assistant: **Concept**

"DECISO - DEVELOPERS OF CIRCULAR SOLUTIONS” aims to support the delivery of services to induce investments projects for developing circular economy at local and regional scale in the following regions: Hamburg. Northwest Germany, West Macedonia, Alentejo. This is in line with implementing the European Green Deal and the EU circular economy action plan. DECISO will accompany the actions aiming to provide assistance for promoters in the development of financial schemes/programs for projects on Circular Economy, based on the concept of Circular Economy Ecosystem (CEE), which implies mobilizing local stakeholders and, when necessary, citizens, and scaling up the results from the local, to the national and European levels.The CEE approach will make it possible to deal with economic, organizational and cultural change through systemic solutions that involve all the players in the value chain of an asset and all those who can influence, even indirectly, its value. This approach also allows reducing risks for investors, because ecosystems with all their key factors, including geographic location, cultural factors and institutional support, actively help an innovation become successful.Since the paradigm of the Circular Economy Ecosystems can be declined in different ways, based on the objective of the initiative, the local context, the type of actors and the sector, the DECISO approach will be implemented in different local contexts and topics in order to produce guidelines that can facilitate the replicability of the initiatives put in place considering all the technical, economic, legislative, and social factors that can determine the success or failure of the initiatives.""


**Keywords:** Circular Economy Ecosystem, Project Development Assistance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Therapeutic in vivo DNA repair by site-specific double-strand breaks'.

assistant: **Innovation**

Sequence-specific alteration of genes in living organisms provides a new strategy for targeted gene repair or trait alteration that has in the last year seen a major breakthrough. The applying consortium has pioneered the toolkits for inducing site- specific sequence alterations at high rates in vivo, and has advanced the technology by using bioinformatics, biophysical, biochemical and molecular biology methods. By specifically stimulating homologous recombination through the creation of targeted site specific DNA double strand breaks, in vivo sequence alteration rates of several percent can be obtained. The double strand breaks are created either by site-specific designer zinc finger endonucleases or triple helix forming oligonucleotides. These advanced bio-molecules will be tested in an array of bio-essays using live cells to identify those with high activity and specificity, which later could be used in gene therapy protocols. Although the previously obtained results are above expectation, numerous improvements of the technology are necessary to increase specificity and efficacy, and to reduce side effects. We suggest to stepwise develop the technique further with the aim of applying this technology platform for the treatment of selected human genetic diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Analysis of euro-Regions R and D GOvernance Systems to reach the 3% objective' in the context of a Sixth Framework call.

assistant: **Objectives**

The project's strategic objective is to promote better and increased R&D investments in participating regions by improving their R&D governance systems and finding a key of coherence between regional, national and European levels to reach the Barcelona target and reinforce the European Research Area (ERA). When analysing their RTD systems, participating regions realised that they faced common problems, notably a lack of coordination between internal players and policies, as well as between all three levels. Thus, these regions confirmed the relevance of the regional governance approach in solving the identified problems, and concluded that the implementation of a public policy aimed at stimulating R&D investments requires a structured governance framework which is able to interact with other regional, national and European players. To address these objectives, a project Work Plan has been drawn up around 7 Work packages (WP). The ARRGOS project will develop new analysis (WP2) and assessment tools, and also a methodology for addressing regional RTD governance systems (WP3). These elements of the ARRGOS instrument package will allow regions to solve a number of common, as well as specific, problems by exchanging successful practices (WP4) and the implementation of common actions (WP5) and initiating individual and collective development of RTD governance systems on both strategic and operational levels. Policy recommendations (WP6) will be disseminated (WP7) to European, national and regional policy makers (and other key players) to provide them with relevant information and experience and to improve appropriation of the projects' results by RTD stakeholders in the partner regions and by other European regions. The expected mid- and long-term impact of the project is an i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'ECONOMIC EVALUATION OF TRANSPORT ACTIVITIES IMPACTS ON MEMBER STATES'.

assistant: **Innovation**

To assess the effect of transport sector activity on the domestic economy of the Member States included and to assess the impact of changes in the economic activity of the transport sector on the domestic economy of these Member States, in different scenarios such as, for example, investment projects, pricing policies or internalisation of external costs To obtain the base information on input-output tables, statistics and econometric models of interestTo establish the methodology of economic evaluation and to adjust the modelsTo develop the computer program and to define the final results and conclusionsLinks with other projects, tasks, areas, programmes, policy actions:Cooperation with tasks 12, 13, 14, 18, 19 and area 1.6.Case studiesBus line in Spain, Infrastructure in the Netherlands or Italy