RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Synthesis of methylene blue  and some new thioether derivatives with an enhanced electrochemical microflow cell' to be submitted under Horizon 2020.

assistant: **Abstract**

Methylene blue is the first fully synthetic drug used in medicine, the most effective and safe medicines needed in a health system. In addition, thioethers derivatives are important materials that are used in organic, bioorganic and medicinal chemistry and are also known to exhibit different biological activities such as antioxidant and antibacterial. These compounds are synthesized commercially by chemical methods that suffer from significant limitations, such as expensive and toxic reagents, solvents, tedious work-up, safety problems. Organic electrosynthesis is recognized as a typical environmentally friendly process with features that many of which cannot be achieved by other methods. Most electroorganic processes are performed under reagentless and mild conditions in one step using efficient and ecofriendly methods and are in agreement with all the principles of green chemistry. Within this field, the use of microreactors in continuous flow is also concurrent with electrochemistry because of its convenient advantages over batch, such as no supporting electrolyte at all, due to the small distance between electrodes; high electrode surface-to-reactor volume ratio, short residence time and etc. This project aims to fabricate an electrochemical flow microreactor by the novel method of photolithography to decrease the interelectrode gap below 100µm. Thus, the resulting device should be suited to the electrosynthesis of a wide range of reactions without a supporting electrolyte solution. Through the present project, we also aim electrochemical synthesis of methylene blue and some new thioethers derivatives for the first time with a facile one-pot and supporting electrolyte-free method. Overall, this method has shown to be a promising tool for electrosynthesis and improvi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Energy efficient redevelopment of buildings listed as a historic monument in combination with a construction' (1994-1998).

assistant: **Innovation**

- energy and ecollogically exemplary reconstruction of houses and the building of a new house with a low energy standard built in a gap between two other buildings- ability to transfer the partly as well as the complete solution to other objects- application of various innovative technologies.INNOVATIVE TECHNOLOGY:Super low energy windows; solar architecture with transparent insulation; opening the south orientated facade with low energy glass (conservatory); useage of warmth isolation of above average standard; solar heating system for hot water and heating support with temperature-controlled variable inlet in a combined heating and solar storage; unique heating concept with combined series and parallel connection of the heating system aiming at the reduction of the connection power and obtained lowest possible return temperatures; useage of rain water in order to reduce the water demand for toilets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Simulation of flexural behaviour of steel fibre reinforced concrete using a lattice type approach', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content This research is concerned by the influence of the interfacial fibre-matrix bond on the performance of Steel Fibre Reinforced Concrete (SFRC). Notched beams are subjected to third-point bend tests. An array of fibres aligned along the beam lenght is placed in the plane of the notch. The interfacial bond strength is altered through an adequate treatment of the fibre surface influence on the macroscopic behaviour of SFRC is nevertheless difficult to measure, given the unavoidable experimental scaner. A better understanding of the observed behaviours can be achieved by simulating the loadZeflection plots. The numerical model must assign different properties to the interfacial bond strength, as to reproduce the influence of the surface treatments Training content (objective, benefit and expected impact) To understand the interfacial bond between fibre and matrix, a detailed analysis of the bond-zone must be realised. The lattice model, developed at the TU Delft, allows such an analysis, although it has never been used for SFRC. The objectives of the requested training are to expand the lattice model to the case of SFRC and to compare simulation with experimental measurements. To be surrounded by people, whose daily task is numerical simulation. and to be given access to the lattice model, represents a true benefit.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Improvement of a therapeutic adjuvanted protein hiv vaccine by combination with dna immunization in prime-boost regimen (HIVPRIMEBOOSTTHERVAC)' (HIVPRIMEBOOSTTHERVAC) under Fifth Framework.

assistant: **Objectives**

An optimal immunotherapeutic regimen will be established and its efficacy evaluated in HIV-infected individuals. The proposal comprises the improvement of an adjuvant protein HIV vaccine for therapeutic use that has proved efficacious in a stringent rhesus monkey SHIV challenge rode. The irnprovement will be achieved through combination of the adjuvant protein vaccine with particle-mediated immune delivery of DNA in prime-boost immunization regimen. This regimen will be investigated in mice and rhesus monkeys for superior immunogenicity and efficacy. One or several prime-boost immunization regimen will be evaluated in initial phase I clinical trials in exonerative volunteers. If the prime-boost combinations are immunogenic, the best combination will be tested for its efficacy in a therapeutic trial in HIV-Positive patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The Middle Class, Civil Rights and Popular Protest in Urban China'.

assistant: **Innovation**

Since the Tiananmen crackdown in 1989, political reform in China has been put on ice.  The one-party state focused instead on turning China into an economic powerhouse that is on track to overtake Japan this year as the world's largest economy after the US.  For the EU, China is now its second most important trading partner.  The world has become increasingly dependent on China for its economic growth.  But for how long can China continue to enjoy the political stability that has underpinned its economic success and now underwrites global prosperity?  Against a background of rising unemployment, a widening gap between rich and poor and rising expectations among its growing middle class, can the authoritarian regime continue to ignore popular demands for greater participation in politics ?   The Communist Party is facing more and more challenges from an increasing number of popular protests and demonstrations that have spawned new social movements to fight for civil rights. Surprisingly, it is homeowners' rights groups in the cities that are in the vanguard of this new wave of protests.  This project will create an alliance between one of Europe's top centres for research on China and the prestigious politics department at Renmin university to analyse how homeowners' rights movements are growing in China's constrained political context.   This alliance is part of a plan build the China Policy Institute at Nottingham into Europe's leading centre for the study of democratization in China. The project will evaluate how homeowners' groups have become the unlikely successors of the democracy movement of the 1980s.  The findings will enable Europeans to assess the prospects for peaceful democratic change in China, or whether to prepare for the unthinkable consequences of wides
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular genetic study of autism' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

To collect standardized phenotypic and biological data in a sample of 200 families with affected relatives with autism.To detect susceptibility loci for autism by performing genomic screening with 250 highly polymorphic microsatellite markers. Autism is a rare (4/10,000) and severe developmental disorder associated with life-long handicaps. Twin studies agree in showing a strong genetic component with heritability estimates no less than 90%. The frequency of autism among siblings of autistic probands is a 100 times higher than the general population rate. Family studies also indicate that the autism phenotype extends beyond the traditional diagnostic boundaries to include characteristic patterns of cognitive (largely language-related) and social deficits. The evidence suggests the operation of several genes acting epistatically; however, there is currently no obvious candidate gene. The proposed research consists of a collaborative study of 200 families in which there are two or more affected relatives (siblings in most instances). An international consortium has been formed under the leadership of the coordinator. Affected relatives will be selected for meeting ICD-10 criteria for autism and for having a non-verbal IQ greater than 35. Standardized phenotypic measures of demonstrated reliability and validity will be employed. Workshops will be organized to train to the administration of these instruments and to maintain comparable and high levels of data quality throughout the project. All interviews and observations will be video or audio-taped to allow running checks on reliability across, as well as within, research groups; clinical data will be centralized in the coordinator's team. Blood samples will be taken from affected pairs, unaffected sibs and their parents a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Social Vaccination in Ant Colonies: from Individual Mechanisms to Society Effects' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Living in social groups leads to a high risk of disease spread. Insect societies counteracted this threat by evolving sophisticated collective anti-parasite defences, combining the immune systems of all group members and their collective social hygienic behaviours. I recently described a direct link between these social and individual defences, by showing that social contact to an infected individual results in a protective Social Vaccination in its nestmate ants: the latter survived an infection with the same pathogen significantly better than control ants that had lived with other healthy ants only. Aim of this project is to elucidate the molecular and physiological mechanisms of this Social Vaccination in individual ants, and its effect on the organisation of collective defences and disease dynamics at the colony level. Preliminary results have shown different protein upregulation in healthy, infected and vaccinated ants, and a detailed analysis of gene and protein expression patterns will define those proteins and their function in anti-parasite defence (postdoc). Observations of the social interactions between infected ants and their group members, and measures of the physiological immune responses of the individuals at different stages of the infection and after the vaccination will further reveal when and how Social Vaccination occurs, how long it endures, and how specific and plastic it is (PhD 1). At the colony level, the social role of vaccinated individuals and the fate of infected ants when loosing their vaccination potential will be determined, as well as the effects of Social Vaccination on disease spread in the colony and the regulation of collective defences between group members (PhD 2). This unique combination studying both the social and individual as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Amenable C*-dynamics and their classification' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Our understanding of amenable C*-algebras has drastically improved over the past decade due to substantial advances in the Elliott classification program. The proposed research is intended to spearhead the classification and structure theory for C*-dynamics, which encompasses groups acting continuously on C*-algebras and the question to which extent their detailed structure is encoded at the level of computable invariants. The objectives involve the following lines of investigation:- The case of discrete groups acting on simple amenable C*-algebras, the latter of which have become accessible due to recent methodological breakthroughs within Elliott's program. The task is to develop a dynamical version of Elliott's program, i.e., to consider natural categories of such group actions, identify functorial invariants such as K-theory and traces, and show that these invariants completely classify a naturally occuring category up to a suitable notion of isomorphism.- The theory of invariants for noncommutative C*-dynamics. This field is faced with numerous open problems requiring solutions before a fully general classification theory can be developed. This part of the project addresses the need for effective computational methods for equivariant Kasparov classes, or systematic techniques to exploit equivariant Ext-theory for the purpose of classification.- The case of noncommutative time evolutions, which includes new rigidity phenomena for the passage of time in simple C*-algebras, both with and without the presence of equilibrium states.A deeply rooted theme within all these objectives is the presence of amenability for the actions and the C*-algebras, which gives rise to radically new phenomena in the context of non-amenable acting groups. Drawing ideas from diverse areas s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a novel high resolution magnetic resonance force microscopy' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content Magnetic Resonance Force Microscopy (MRFM) for sub-micron imaging and spectroscopic characterization of smaU objects is an emerging new technique with great potential for study of inhomogeDeous materials like biological materials, polymer blends, etcetera. The main feature of this detection method of magnetic resonance is the ability of achieving information from a very small and localised spin system. The present approach is based on measuring a NMR generated force by mounting the sample on a micro cantilever which is placed in a inhomogeneous field generated by a magnetic particle. The disadvantage is that the sample has to be smaU (in the microto nanogram region). In this project we propose to reverse the roles and mount the magnetic particJe on the micro cantilever. This has a number of advantages which will make the method much more general applicable. For example the sample can now be large while with the usual microprobe scanning methods one can nevertheless find the microscopic interesting parts of the sample for observation. However a number of formidable technical problems have to be overcome related | to the extreme weakness of the cantilevers combined with the large forces exerted in very high magnetic fields. Training content (objective, benefit and expected impact) The training involved in the project will allow the candidate to develop and complement his experience in magnetic | resonance techniques. These wiU include working with NMR equipment of the highest standard in the National Dutch | NMR centre and with novel combinations with scanning probe techniques. The candidate will gain insight in the| different NMR methods and in the relevance for industrial applications. Links with industry/industrial relevance The host gro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovative, low cost, low weight and safe floating wind technology optimized for deep water wind sites' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Many elements of an offshore wind farm become more expensive as depth increases: mooring, anchoring and dynamic cables are the most obvious. However, deep water areas also pose additional challenges for installation and O&M strategies. FLOTANT project aims to develop an innovative and integrated Floating Offshore Wind solution, optimized for deep waters (100-600m) and to sustain a 10+MW wind turbine generator, composed by: a mooring and anchoring system using high performance polymers and based on Active Heave Compensation to minimise excursions, a hybrid concrete-plastic floater and a power export system with long self-life and low-weight dynamic cables. The project includes enhanced O&M strategies, sensoring, monitoring and the evaluation of the techno-economic, environmental, social and socio-economic impacts.The prototypes of the novel mooring, anchoring and dynamic cable components, and a scaled model of the hybrid offshore wind floating platform will be tested and validated within the scope of the project. Three relevant environments have been selected to perform the tests: MARIN basin for global performance under controlled conditions; the Dynamic Marine Component Test facility (DMaC-UNEXE) for large scale prototypes tests; and PLOCAN Marine Test Site, for the characterisation of novel materials under real seawater conditions.An expected 60% reduction in CAPEX and 55% in the OPEX by 2030 will be motivated by FLOTANT novel developments including additional sectorial reductions due to external technology improvements. Overall FLOTANT solution, will allow an optimisation of LCOE reaching values in the range of 85-95 €/MWh by 2030.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Acoustic whole blood imaging flow cytometry for rare cell identification' to be submitted under Horizon Europe.

assistant: **Abstract**

This project addresses the need for new tools to detect and monitor the disease progression in patients with metastatic cancer. Breast and prostate cancer are the most common malignant cancers in women and men, respectively. Metastasis is the main threat in these cancers since it turns a curable local disease into a chronic lethal disease. With emerging new targeting therapies, there is an unmet clinical need for improved prognostication, treatment prediction and treatment monitoring, where circulating tumor cells enumeration have potential to become a valuable tool. But circulating tumor cells are very rare and the background of other blood cells is vast which makes it extremely challenging to classify and count these cells.In the project, we will develop acoustic whole-blood cytometry. This will enable unbiased imaging and enumeration of circulating tumor cells through a panel of fluorescent antibodies with minimal pre-treatment. The vision is that the approach will become standard equipment in hospital labs in the transition to more personalized healthcare.The project will evaluate key technical challenges on the path to commercialization. The project has strong support from an industrial partner and from clinicians and pre-clinical researchers focused on breast and prostate cancer.