RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quantum Estimation and Control for Advanced Noisy Metrology' under Horizon Europe.

assistant: **Concept**

In recent years, the idea of building quantum technologies has quickly moved from being an intellectual curiosity to a practical reality and quantum metrology and quantum sensors are prominent ones, already in use in scientific and commercial applications. The underlying idea is to exploit genuinely quantum effects to perform extremely accurate measurements, with a precision not achievable by classical means.While many important theoretical and experimental milestones have already been reached, there are still many open theoretical questions left on the path to understanding the ultimate capabilities of quantum metrology, especially in realistic operating conditions.We have identified three main pillars that are currently subject to very active research: i) understanding the ultimate limits of the quantum estimation of multiple parameters simultaneously, either because all of them are of practical interest, or because a full prior characterization of additional system's parameters is not possible; ii) assessing the impact of environmental noise on the quantum probe, in particular beyond the standard assumption of uncorrelated noise; iii) understanding the limits of metrological schemes based on time-continuous measurements, nowadays feasible in many physical systems (e.g. superconducting qubits, optomechanics), which open the possibility to perform measurement-based feedback control on the system.The overarching goal of this action is to advance the state of the art in these three areas and to connect these three pillars, by devising new theoretical tools to assess the ultimate precision limits in novel and physically relevant scenarios. These tools will be rooted in quantum estimation theory and quantum control theory and they will provide fundamental benchmarks for th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Human subsistence and climate change in European refugia: late Neanderthals and early modern humans'.

assistant: **Innovation**

EUROREFUGIA aims to contribute to the on-going debate about the causes of the rapid replacement of Neanderthals by modern humans in Europe around ±45 kyr BP and the probable difficulties that the former could have faced while withdrawing to certain refuge areas until their final extinction ±10 kyr years later. This is a key period of human evolution that witnessed the confrontation of two different but advanced cultures. Among other possible explanations, EUROREFUGIA focuses on the palaeoeconomic perspective, and hence, it will characterize the hunting skills of both human species and, above all, their ability to cope with a changing scenario.To do so, EUROREFUGIA will study faunal material of the two main known refugia: the Balkans and the Iberian Peninsula, with a multidisciplinary approach that includes:1.An updated archaeozoological analysis of the unpublished macromammalian remains belonging to the last Neanderthal and earliest modern human occupations of La Viña rock shelter and El Miron Cave, on the Cantabrian Coast, and Salitrena Pecina, in Central Serbia.2.A detailed reconstruction of the strategy of subsistence adopted by both human species: diet-breadth, butchering processes (taphonomy), human mobility, transport decisions, catchment areas (GIS) and intra-site spatial organization.3.A complete analysis of stable isotopes (C, N and O) of red deer fossils sampled from contemporaneous archaeological sites in both regions, which will provide the palaeoenvironmental context where both human species lived.4.An estimation of the relationship between diet, demography, topography and climate change in order to investigate whether climatic variability, lack of suitable technology to exploit different biotopes, increasing competition or resource depletion could have cau
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fuelling the Future: Advancements in Trifunctional Catalysts for Renewable Biofuel Synthesis' (ADVENTUROUS).

assistant: **Innovation**

The ADVENTUROUS project, harmonizes with the European Green Deal's 2030 climate targets and the broader EU ambition of reaching carbon neutrality by 2050. It is firmly rooted in the pursuit of catalytic trifunctional systems for the transformative synthesis of sustainable advanced fuels (SAF) derived from renewable feedstocks. The crux of this endeavour rests upon the innovation of two core facets: the integration of catalysts that can seamlessly host diverse catalytic sites and the genesis of an entirely novel synthetic avenue for the production of sustainable aviation fuels (SAF). This project sets forth on a path towards sustainable development, poised to chart a course marked by a near-zero emission CO2 cycle.ADVENTUROUS leverages the expertise of Dr. Camilla Maria Cova in organic synthesis and green synthesis, complemented under the supervision of Prof. Svetlana Ivanova, with broad experience in multifunctional heterogeneous catalysis at the University of Seville (USE). The fruit of this necessary collaboration will be the advanced design and application of a multifunctional catalyst able to revolutionize the biofuel synthesis. What is more advanced technologies such as ultrasound-assisted reactions will be tested for an environmentally sustainable catalyst production and the success of the project will opens a completely new pathways not only to SAF production but also to a numerous starting molecules for fine chemical synthesis.ADVENTUROUS is aligned with the MSCA Green Charter, emphasizing environmental responsibility and sustainable development. By developing sustainable biofuels and innovative catalysts, it contributes to achieving the objectives of decarbonization, energy efficiency, and increased use of renewable energy sources in the transportation sector.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Nanoparticle-Based Therapeutic Applications and Detection of Carbon Monoxide Releasing Molecules'.

assistant: **Concept**

Carbon monoxide (CO) has gathered increasing attention because of its role as a gasotransmitter with therapeutic and cell-protective effects. It is also recognised as a cell-signalling molecule where recent developments in the area of CO-releasing molecules (CORMs) and materials for controlled CO application have shown their importance with respect to delivery of such agents to their respective targets. However, despite their promise, their remains two major bottlenecks that may prevent these compounds from reaching the clinic. Firstly, the precise spatial-temporal CO release of CORMs is not target-specific. The CO molecule is highly diffusive and binds to haemoproteins, which are ubiquitous. Secondly, CORMs are made of metal carbonyl complexes and as organometallic compounds, there is the potential of heavy metal toxicity. Moreover, since CORMs are water-soluble they are distributed throughout the body, which can lead to further increased toxicities against healthy tissues. Our project aims to alleviate some of the problems of CORMs by a) developing a method to monitor CO release by MRI and optical imaging; b) reformulate CORMs by encapsulating inside nanomaterials (specifically the FDA approved PLGA as a nanocarrier) and c) provide targeting of the CORMs to their site of delivery by conjugating peptide targeting moieties to the surface of the PLGA nanoparticle. Through the completion of these activities, I;;, supported by its twinning partners, is in the best position to achieve an improved capability to compete for internationally competitive research funding and to access business stakeholders. By claiming its position in research and innovation networks IMM will effectively contribute to research excellence and value creation in health at European level.


**Keywor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Controlled Component and Assembly-Level Optimization of Industrial Devices' (CASOPT).

assistant: **Concept**

The CASOPT Project Consortium consisting of ABB, University of Cambridge, Technical University of Munich and Technical University of Graz proposes to facilitate a paradigm change from state-of-the-art Simulation-Based Design to novel Optimisation-Based Design of complex electromagnetically-driven industrial products.  This new design philosophy will first enable automatic, physics-governed re-sizing / miniaturisation of complex environmentally-friendly device assemblies and at the same time enforce a re-thinking of industrial design in general.  Our complete physics-based optimization system includes: component-level optimisation,   automatic mesh smoothing/exporting, fast Boundary-Element solvers, design-criteria evaluation, assembly-level optimisation and is importantly supported by high-performance computing.    Within this highly multidisciplinary and inter-related project we compiled a team of world-class experts in numerical analysis, multi-physics simulation and optimization, geometric design and parallel computing. The realisation of this project essentially relies on already available site competencies, knowledge transfer through secondment and is supported by additionally recruited experts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Role of fgf receptor 1 and 2 in the midbrain development and dopaminergic neuron differentiation' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

Patterning of midbrain and specification of the midbrain dopaminergic neurons is controlled by signalling molecules Sonic hedgehog (Shh) and Fibroblast growth factor 8 (Fgf8). In embryogenesis, Fgf8 can transduce its signal via three Fgf receptors (Fgfr). W e want to find out whether Fgfr 1 and 2 are required for differentiation of the midbrain and the midbrain dopaminergic neurons.Our model is conditional inactivation of Fgr1 and 2 in mice. We will perform spatially and temporally controlled ablation of Fgf r1/2 genes in mutant mice as well as in ex vivo cultured midbrain explants using an inducible Cre recombinase, adenovirus mediated gene delivery and embryo electroporation. Consequently, we want to clarify molecular mechanisms of Fgf receptor mediated signalling. Morphogenesis is the consequence of subtly regulated balance between proliferation and differentiation.We suggest that Shh and Fgf8 direct the midbrain development by modulating expression of c-myc and or n-myc well-known regulators of proliferation and differentiation. C -myc/n-myc overexpression and siRNA-mediated gene silencing in wild type and Fgfrs mutant mice will be carried out to analyze the role of the myc genes in control proliferation/differentiation in midbrain.The study of dopaminergic neuronal specification and maintenance has significant clinical relevance, as it will advance our understanding of neuron's degeneration in Parkinson's disease and may offer therapeutical tools for the treatment of the ailment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Centre for Railway Engineering, Science and Technology' (CREST), addressing dissemination and exploitation.

assistant: **Impact**

Activity of proposed CREST Centre of Excellence is to achieve the EU transport policy goals by fulfilling priorities of the FP5 Key Action 2 of the Growth Programme. The CREST centre capacity building is aimed on preparation the railway research base to achieve expected passenger and goods mobility and to fulfil standards for environment protection in cost-effective way. The aim of CREST centre activity is also preparation of joint participation in EU 6th Framework Programme projects. The CREST specific objectives are as follows: - to strengthen links with the EU, NAS and Polish railway research centres; - to develop a network with Russian and Ukrainian railway engineering institutes; - to open research infrastructure of CNTK for leading European scientists; - to improve post-graduate courses by giving them international dimension.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'BK potassium channels in the brain: their properties, distribution and function' (1994-1998).

assistant: **Innovation**

To investigate the properties, distribution and function of BK channels (also called maxi-K or slo channels).To determine the extent to which BK channels serve to limit hyperexcitability, calcium influx, excitotoxicity and cell death in brain disorders such as epilepsy and stroke, in order to provide a basis for assessing the therapeutic potential of pharmacological manipulations of this channel type.Among the ion channels that regulate neuronal activity, the potassium (K)channels form the most diverse group, playing multiple roles in brain activity and disease. Thus, K channels not only set the resting potential and regulate nerve impulses; they are also essential for preventing pathological hyperactivity, such as epileptic discharges, or the excessive calcium (Ca)influx, exitotoxicity and cell death following ischemic brain injury. The pharmaceutical industry therefore shows considerable interest in K channels. ASME that is in the forefront of developing K channel modulators against brain disorders, is a key participant in this proposal. This project focuses on a particularly prominent and widespread type of Kchannels in the brain, the BK channels (also called maxi-K or sloehannels).This channel type has a unique set of properties, and can be subject to extensive physiological and pharmacological modulation. In spite of this, little is known about its functional roles. Our goal is to determine the extent to which BK channels serve to limit hyper-excitability, Ca influx, excitotoxicity and cell death in brain disorders such as epilepsy and stroke, in order to provide a basis for pharmacological exploitation of this channel type.Recently, a series of new tools and methods has been developed: selective toxins, radioligands and modulators, and improved methods for mapping
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'End use and substitution analysis for sawn timber and wood based panels : implications for European forestry' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The objectives of this concerted action are: 1. To pool existing knowledge of end uses trends of sawn timber (softwoods and hardwoods) and wood based panels in Europe and methods of end use analysis. 2. To collate trends in the substitution of sawn timber and wood panels in Europe by other wood and non-wood products and to evaluate methods of substitution analysis. 3. To assess the need by the wood based industries and forest sector policy makers for systematic and consistent studies on end uses and substitution. 4. To discuss future research collaboration between the partners and associate partners.  The objectives will be met by holding two workshops attended by the partners and associate partners, all of whom are leading practitioners of end use and substitution analyses for wood products. The objectives of the proposal are relevant to two key issues for the future of European forestry. The first relates to the diverging trends of raw material requirements and resource availability. Whilst the forest industries increasingly use small roundwood, silvicultural and management regimes continue to put greater emphasis on the production of saw logs. Second, the solid wood processing industries (sawmilling, joinery, furniture) are important employers in rural forest areas. The predicted slower growth in demand for solid wood products compared with newer materials could jeopardise employment and incomes in these regions. An understanding of the changing end uses for sawn timber and wood based panels and of substitution trends affecting these products contribute to a better appreciation of their impact on silvicultural priorities and forest based employment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New Innnovative and cost effective metal cleaning machine' (METALCLEAN).

assistant: **Innovation**

METALCLEAN is an innovative equipment for high precision cleaning of metal parts based on the engineered tailoring of several operational parameters. Cleaning is an unavoidable stage of the production process in industries manufacturing or assembling metal parts. During the different machining processes, organic substances, dust or small metal chips can attach to the surface of the manufactured goods. In this way, parts need to be cleaned after metal fabrication and assembly and prior to painting and coating. Therefore metalworking industries and their clients demand cost-effective cleaning systems with low energy and solvent consumption. The unique design and operational parameter of METALCLEAN, without the need for vacuum and with a unique solvent recovery and distillation system enable energy savings of up to 52% compared to the other metal-cleaning machines currently in the market. The first METALCLEAN units will reach the market in May 2018. Through its market deployment we aim to impact into the market of metal-cleaning devices by commercializing a final product that will help our customers improve the performance, reduce operational costs (thanks to reduced energy consumption and increased solvent recovery) and reduce the environmental impact of the cleaning process, reducing the waste treatment of the solvents thanks to its recirculation system. Moreover, it will also imply savings for our customers (as our solution will have an initial target price 33% lower than current solutions in the market) and hence for the final end-users, e.g. –watch manufacturers, automotive and aircraft industries or electronic devices manufactures) who will benefit from an improved cleaning of their products at a competitive price. According to our preliminary forecasts, we expect sa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Tracing Microbes using Phosphate in Fe-oxide Environments' (TMUPIFE) targeting Seventh Framework.

assistant: **Abstract**

Acid drainage from unused mines (AMD) is a global problem. In these environments understanding the role of microbes is critical to predict its remediation as well as creation, but is also important due to its recent use as an analogue for the surface of Mars. Measuring microbial activity using isotopic signatures is a well-established idea used for AMD production, however, is typically only applicable to the metabolism of specific microbes. In contrast, fractionation in phosphate that is required by all forms of life, has been shown to be a viable tracer for biological activity in near neutral environments by Prof. Blake at Yale University. At acidic conditions different speciations of phosphate play an important role in O fractionation but the signatures associated with minerals such as Fe-oxides and microbial metabolism is unknown. Thus, the proposed project will use a synergy of experimental, analytical and computational techniques to test whether the isotopic fractionation of oxygen in phosphate can be used as an isotopic tracer in acidic systems. To do this fractionation associated with relevant microbes and Fe-minerals will be examined using experiments, analysed by state of the art Thermo-Chemical Elemental Analysis and compared to natural AMD samples in the outgoing phase at Yale University. To predict whether these signatures can be retained within the Fe-minerals computational simulations, conducted at the return host University College London with Prof. de Leeuw, will be used to examine phosphate adsorption to different Fe-minerals and the competition of other molecules for adsorption sites. The proposed project offers the European scientific community the opportunity to transfer unique skills whilst simultaneously generating cross disciplinary collaborations