RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'RISC-V GENERATION OF  HIGH PERFORMANCE AUTOMOTIVE PROCESSORS AND COMPUTING PLATFORMS' (Rigoletto) under Horizon Europe.

assistant: **Objectives**

Electrification and autonomy drive the rapid evolution of modern vehicles, requiring increasing computational capabilities, coupled with safety and efficiency.  The classical, decentralized multi- Electronic Control Units (ECU) architecture has significant drawbacks when it comes to scalability, and it is becoming untenable.  The dominant megatrend pushes for an increasing number of key functionalities to be software-defined, with the direct implication that the software content (lines-of-code) in a vehicle will grow by 10x in just 5 years,  to 1 billion by 2030. From a hardware viewpoint, increased complexity and autonomy requires a more centralized approach to on-board computing to curtail cost, latency and bandwidth bottlenecks  of the in-vehicle network. Centralizing the E/E architecture requires merging multiple Electronic Control Units (ECUs) into powerful, fully programmable Domain Control Units (DCUs) or Zonal Control Units (ZCUs).To address this paradigm shift, the  Rigoletto  project  will establish the foundation for a  next-generation Automotive Hardware Platform based on the open RISC-V instruction set architecture (ISA), bolstering and securing Europe's leading role in the automotive electronics industry.  The project aligns with the high-level goal of EU Chips Joint Undertaking and the of the industry-led Vehicle of the Future initiative: namely,  the creation of a RISC-V based automotive hardware platform strongly linked with the formation of an open, software-defined vehicle ecosystem led by European automotive manufacturers and suppliers. Rigoletto aims at developing  RISC-V intellectual property (IP) components, including processor cores, accelerators, interconnects, memory hierarchy and peripheral subsystems. A wide range of performance profiles will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Emergent spacetime and maximally spinning black holes' to be submitted under Horizon 2020.

assistant: **Abstract**

One of the greatest challenges of theoretical physics is to understand the fundamental nature of gravity and how it is reconciled with quantum mechanics. Black holes indicate that gravity is holographic, i.e. it is emergent, together with some of the spacetime dimensions, from a lower-dimensional field theory. The emergence mechanism has just started to be understood in certain special contexts, such as AdS/CFT. However, very little is known about it for the spacetime backgrounds relevant to the real world,  due mainly to our lack of knowledge of the underlying field theories.My goal is to uncover the fundamental nature of spacetime and gravity in our universe by: i) formulating and working out the properties of the relevant lower-dimensional field theories and ii) studying the mechanism by which spacetime and gravity emerge from them. I will adress the first problem by concentrating on the near-horizon regions of maximally spinning black holes, for which the dual field theories  greatly simplify and can be studied using a combination of conformal field theory and string theory methods. To study the emergence mechanism, I plan to adapt the tools  that were succesfully used to understand  emergent gravity in anti de-Sitter (AdS) spacetimes  - such as holographic quantum entanglement and conformal bootstrap - to  non-AdS, more realistic spacetimes.


**Keywords:** black holes, holography
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The human Parietal Lobe' (PARIETALACTION).

assistant: **Concept**

We will use univariate and multivariate functional Magnetic Resonance Imaging (fMRI) techniques, surface and stereo EEG, and in depth single cell recording to investigate the role of human parietal lobe in the monocular or stereoscopic observation of actions performed by conspecifics either using their biological effectors or artificial implements (tools, spears, bicycle, microphone, etc). The fMRI techniques will provide evidence for segregated processing of different types of observed actions within the parietal cortex. The EEG techniques will provide the time course of the electric activity in the parietal regions in comparison to the events and dynamic changes in the video and the time course in other parts of the action observation network. The stereo EEG also provides a more precise localization than fMRI, serving as an important confirmation of the fMRI results. The single cell recordings are crucial to demonstrate the selectivity of the neuronal processes for actions observed, their postural or kinematic parameters or localization in the visual field. This selectivity is crucial to show the presence of mirror neurons for the different types of actions and the use of tools, to document the contribution of the parietal neurons to discrimination between actions, and to assess the benefits of stereoscopic viewing. This project should yield a comprehensive view of the role of parietal lobe in action planning and understanding, including using artificial implements, and pave the way for understanding how higher-order parietal cognitive processes are rooted in the simpler action planning and understanding capacities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'TRIOP: an intraoperative probe to assess tumor margins and remove tumor residues in real time' in the context of a Horizon Europe call.

assistant: **Objectives**

Cancer is the 2nd most common cause of death worldwide. Oncological surgery is the most efficient single-treatment and is the most used as primary treatment. However, the local cancer recurrence rate after the first surgery is still high in every organ. Local cancer recurrence is mainly caused by tumor growth from remaining tumor residues. They have a major impact on survival, quality of life and require reinterventions and/or adjuvant treatments. Therefore, the main issue today in oncological surgery today is to ensure the resection quality and remove the whole tumor while minimizing healthy tissues removal. To achieve it, surgeons need real time information on tumor residues’ location.Beams is a medtech company, incorporated on the 17th of May 2021 to answer this unmet medical need. Beams develops TRIOP (Tumor Resection IntraOperative Probe) technology, a miniaturized intraoperative probe which measures the accumulation of existing radiotracers in tumor tissues after their injection in the organism, and then informs surgeons in real time about the precise tumor localization to help removing the tumor while preserving surrounding healthy tissues. The targeted impact is to prevent local cancer recurrence and to preserve patients’ quality of life.The first Beams’ product based on TRIOP technology will be a multi-purpose intelligent surgical aspirator: the detection system will be built around an aspiration tool, to remove tumor cells, blood and other secretions that could alter the detection simultaneously with examining the operative cavity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'miRNA biomarkers of Osseous Metastases in Serum from breast cancer patients' under Horizon 2020.

assistant: **Concept**

Bone metastasis is a common complication for breast cancer patients, affecting 70% of patients diagnosed at advanced stages. Blood-based microRNAs (miRNAs) have received considerable research interest as biomarkers in cancer. The identification of biomarkers predictive of bone metastasis may be useful for the administration of preventative drugs such as bisphosphonates. In this study, a large-scale screening analysis of > 700 miRNAs will be performed in serum from breast cancer patients with and without visceral or bone metastasis. We will further evaluate candidate miRNAs using serum samples from a second cohort of breast cancer patients who were examined prospectively (with 8 years of follow-up) for relapses in bone and non-bone sites. At this stage, we anticipate the identification of a miRNA signature predictive of bone metastasis in patients with early-stage breast cancer. The second part of this study will assess the role of these miRNAs in the tumour-bone microenvironment. Circulating miRNAs may derive from bone cells or the tumour, and may enter the circulation through cell-derived vesicles called exosomes. We will study the biological functions of miRNAs dysregulated in patient serum. Overlaps between miRNAs in the serum and exosomal miRNAs that are derived from tumour cells or osteoclasts will be further assessed using in vitro and in vivo models of bone metastasis. By studying the activities of these exosomal miRNAs in the bone microenvironment, we may be able to better understand bone metastasis as well as identify new miRNA-based therapeutic targets.


**Keywords:** miRNA, biomarker, serum, exosomes, bone metastasis, breast cancer, metastasis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New European Aviation Research Strategy', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Objective of the ProposalThe proposed project shall provide driving support to the development of a strategic agenda for research in Europe for a 2030+ horizon. In particular, it will initiate and execute the involvement and consultation of all major stakeholders of this sector for the development of the agenda.Background to the ProposalIn 2001, the Group of Personalities, initiated by then-EC Commissioner Philippe Busquin, presented their Vision 2020 on the future of air transport and the resulting challenges for European research. This report was the impetus for founding the Advisory Council for Aeronautical Research in Europe (ACARE), which published the Strategic Research Agendas SRA 1 (2002), SRA 2 (2004) and a 2008 Addendum to SRA 2.Currently, a new ""Vision"" aiming beyond 2030 is projected and is expected to be available at the start of this project. This Vision, in combination with the findings of evaluation and assessment projects such as MEFISTO and AGAPE, will form the basis upon which a new roadmap for European research will be developed.Expected Deliveries and ImpactThe new agenda will be the focus for future aeronautics and air transport research, on the European level as well as for national and industrial programmes. The aim is to ensure that, in times of unpredicted challenges and limited resources, mobility needs of the European citizen are satisfied safely and more sustainably, and that Europe continues to maintain its leading position in a technology sector of strategic and commercial importance and political prestige.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Security And InteroperabiLity in Next Generation PPDR CommUnication InfrastructureS' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Public Protection and Disaster Relief (PPDR) agencies in EC member states are relying on digital Private Mobile Radio (PMR) networks for mission-critical voice and data communication. These networks are highly resilient and properly dimensioned to cope with crisis and emergency handling, and are well protected against monitoring and intrusion by means of encryption, authentication and integrity. The two main standards for digital PMR networks in Europe are TETRA (TErrestrial Trunked RAdio) and TETRAPOL.The majority of these networks are based on mature technology, requiring old-fashion synchronous links (backbone), and using proprietary hardware solutions that eventually become obsolete. These networks also provide limited inter-technology coverage providing very ineffective management  of emergency events, both at the national level and in cross-border regions.The main goal of SALUS is to design, implement and evaluate a next generation communication network for Public Protection and Disaster Relief (PPDR) agencies, supported by network operators and industry, which will provide security, privacy, seamless mobility, QoS and reliability support for mission-critical PMR voice and broadband data services. The project covers the full techno-economic scope regarding development and deployment of the next generation PPDR networks by focusing on the integration with / migration to 4G wireless communications developments targeting three critical  scenarios 1) city security, 2) disaster recovery, and 3) temporary protection. Salus will address key research challenges such as enterprise architectures, economic and business analysis, and a number of technical aspects concerning QoS, resilience, inter-systems handover (secure, seamless and fast), enhanced security, privacy mechani
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tackling European Water Challenges' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Water is a critical resource for the European society. Beside its main life function, freshwater also provides many other functions essential to our economy such as transport, energy provision, heat exchange, cleaning, washing, and constitutes a necessary raw material for many industries. Water availability in sufficient quantities and adequate quality is an issue of highest priority and represents a pan-European and global societal challenge. Water challenges cannot be successfully tackled through the isolated effort of individual national research and innovation programmes. A significant share (more than 70%) of public spending in water research and technology development is programmed, executed and evaluated at national level.Joint Programming Initiatives (JPI) aim at a coordinated and strategic approach to public national and regional research and innovation funding in Europe. Ten critical societal challenges have been identified in Europe and are being addressed through Joint Programming. “Water Challenges for a Changing World” (the Water JPI) is one of them. The Water JPI aims at achieving sustainable water systems for a sustainable economy in Europe and beyond.WatEUr will prepare and support the successful development and implementation of the Water JPI. WatEUr will permeate the structures of the Water JPI to impulse progress towards JPI objectives. Now that Water JPI Vision and Management Structure have been developed, actions are needed to sustain the current structures and to fasten progress in joint activities between national/regional programmes in Europe that will make the Water JPI instrumental to the Research, Development and Innovation community, and effective in tackling European water challenges. Examples of such joint activities include the recurrent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Re-engineering of fungal sulphur metabolism to limit mould viability and virulence.'.

assistant: **Innovation**

Aspergillus fumigatus, the major mould pathogen of human lungs, is responsible for > 2 million illnesses per annum in Europe . I have discovered that sulphur is an essential host-derived element during A. fumigatus infection . This finding is novel, and highly exploitable as a) Synthesis of the sulphur-containing molecule methionine appears to be essential for viability of A. fumigatus b) Regulation of sulphur assimilation is essential for A. fumigatus virulence and c) The foremost candidate sulphur source in mammalian lungs (H2S) is gaseous, and recently identified as a novel signalling molecule in eukaryotic cells . I now wish to harness world-class clinical and scientific expertise in the field of fungal pathogenicity to identify the precise molecular source of sulphur exploited by A. fumigatus during experimental and clinical infection, with a view to designing novel antifungal therapies.OBJECTIVES1. To define the role of methionine synthase in A. fumigatus viability I will enforce a mutational blockade upon biosynthesis of the sole methionine precursor, homocysteine, while leaving methionine synthase intact. This will decipher between essentiality of methionine biosynthesis, and essentiality of a secondary function of the methionine synthase enzyme. 2. I have eliminated cysteine and oxidized inorganic-S sources as in-host sources of sulphur. I will now address, via mutational analysis in the fungus, in-host transcriptome and transgenic mice whether methionine or H2S are exploited in the host. Having defined the S-source exploited in vivo, I will seek correlates with human disease by scrutinizing human and fungal genome sequences for SNPs associated, respectively, with human H2S production and fungal sulphur assimilation.3. I will use A. fumigatus mutants deficient
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Impact of exposome on the course of lung diseases', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are two very debilitating non-communicable diseases that are of particular interest to consider in parallel in a human exposome study. Their roots are opposite: COPD is currently considered to be mainly related to the external exposome, while factors outside of the exposome play a major role in CF. However, COPD and CF share common characteristics such as high phenotypic variability of unknown origin, which prevents good therapeutic efficacy. It is therefore clear that the overall picture must be supplemented by taking into account additional components of the exposome than those currently considered in COPD and CF. Thus, the overall objective of the REMEDIA project is to extend the understanding of the contribution of the exposome, taken as a complex set of different components, to COPD and CF diseases. We will exploit data from existing cohorts and population registries in order to create a unified global database gathering phenotype and exposome information; we will develop a flexible individual sensor device combining environmental and biomarker toolkits; and use a versatile atmospheric simulation chamber to simulate the health effects of complex exposomes. We will use machine learning supervised analyses and causal inference models to identify relevant risk factors; and econometric and cost-effectiveness models to assess the costs, performance and cost-effectiveness of a selection of prevention strategies. The results will be used to develop guidelines to better predict disease risks and constitute the elements of the REMEDIA toolbox (global unified database, sensor device, versatile atmospheric simulation chamber, machine learning supervised analyses, causal inference model, Pan-European multi-c