RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The MECHanical GENome: How DNA sequence guides chromosomal organization and dynamics'.

assistant: **Concept**

Beyond its role in encoding the primary structure of proteins, the sequence of DNA also determines its mechanical properties such as shape and flexibility. This sequence-specific mechanical code significantly influences interactions between the cellular machinery and the genome, affecting critical processes such as gene regulation and chromatin organization. However, the extent to which this MECHanical GENome drives biological function remains largely unexplored. MECHGEN seeks to bridge this gap by leveraging a recently developed coarse-graining methodology to construct a multi-resolution molecular dynamics (MD) model that integrates sequence-dependent elastic properties of DNA. This model will enable efficient simulations of genomic length DNA, chromatin, and other biologically relevant systems.Using this new methodology, we propose to study two aspects of chromosomal organization. The first will investigate how DNA sequence influences the distribution of topological strains and how sequence context determines the exposure of DNA damage in supercoiled DNA, offering new insights into genomic stability and repair mechanisms. The second line of investigation will explore how DNA sequence shapes chromatin structure and function, focusing on nucleosome positioning and higher-order chromatin architectures. By combining coarse-grained simulations with experimental data, MECHGEN aims to clarify the role of sequence variations in chromosomal organization and gene regulation. These findings could significantly impact our understanding of genomic function and stability, with potential applications in the study and treatment of genetic diseases.


**Keywords:** Polymer physics, DNA, Chromatin, Supercoiling, Coarse-graining
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Center for Antibody Production Rijeka: Upgrading the Central Research and Service Infrastructure for the South Eastern Region of Europe' (CAPRI2010).

assistant: **Innovation**

The Center for Proteomics was established at the Medical Faculty, University of Rijeka in 2006 with focus on monoclonal antibodies (mAb) development for cutting-edge applications including proteome analysis. Since its inception, the Center has succeeded in establishing several high level scientific collaboration projects in the Region and EU. The most important project is aimed at the development of mAbs against the entire Varicella Zoster Virus proteome. The Center has now several hundred hybridoma cell lines at its disposal secreting mAbs to a large variety of target proteins. This collection will soon be made available to the scientific community. The Center is a member of ""ProteomeBinders"", an EU FP6 CA project, aimed at planning a resource of affinity reagents for analysis of the human proteome. Thus, the Center is strategically positioned to serve as a key resource for basic and clinical scientists in the Region and an important resource to the European scientific community. CAPRI2010 will extend the mission of the Center in order to attract scientists and enterprises from the Region and from the whole of Europe with interests in the fields of mAb technology and proteome analysis.  It will enable the Center to achieve self sustainability on the long run. The key activities of CAPRI2010 consist in the establishment of new scientific collaboration in mAb development and application, e.g. in proteome analysis. Through the support intended by this REGPOT call, the entire region will benefit from the activities of the Center through (1) upgrading the infrastructural resources and (2) mobilizing human resources by providing special training and education. The Center is unique and will therefore optimally serve the development of research and technological potential in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Past Lifeways and Deathways of the Disabled in 14th-18th Century Central Europe: an Interdisciplinary Study' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Disabled constitute around 20% of nowadays society and were a significant number in the past. The remains of disabled are part of archaeological heritage, and reconstruction of the life of the disabled enriches our understanding of common human heritage and the past. The goal of this project is to reconstruct lifeways and deathways of disabled in the 14th-18th century in Central Europe. As a result I expect to gain knowledge on: definition of disability, social status, gender, origin and burial customs of disabled as a group and individuals. I will investigate two populations (300 skeletons) from Poland as well as medical texts, chronicles and ethnographic sources from Central Europe that describe aspects of life and death of disabled. The project is highly interdisciplinary because it integrates archaeology (analysis of artefacts and graves), bioarchaeology (paleopathology, stable isotopes), history and ethnography (heuristic and hermeneutic analysis). These methods have not been linked before to study disability in archaeology. This project continues the socio-cultural approach in research on disability that emphasizes importance of archaeological and textual data to research on disability. This project extends this approach by developing interdisciplinary and cutting-edge methodology and studying new topics: the origin of disabled and new regions: Central Europe.The project will constitute the first comprehensive study on disabled from Central Europe and include them in academic narration, culture and social debate. The project will uncover heritage of disabled from Central Europe that is part of the European and worldwide heritage. Science communication activities will show the public the treatment of disabled in the past and help the disabled to understand their hi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Clean energy recovery from biomass waste & residues (BIOWARE)' (BIOWARE), addressing dissemination and exploitation.

assistant: **Impact**

The project centers on reduction of the main pollutants and PM emissions from bio-waste combustion by a cost effective one-step combined dry gas cleaning and particle removal system based on ceramic filter candles. The main innovation of the system is the introduction of a selective catalytic process in the candle medium to reduce NOx. The novel gas cleaning system will be developed and tested by performing both laboratory experiments, and filtration tests in a small scale bubbling fluidised bed combustion plant. The system will be optimised for special biomass/waste fuels: leather waste from shoe industry, olive oil production waste and wood chips. The project will be accompanied by social, economical and environmental impact studies in order to set up criteria for the implementation of the developed cleaning/filtration technique and plant concept in other European areas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular mechanisms for building the brain: molecular genetic analysis of brain development in the neurogenetic model systems drosophila and mouse' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Understanding the cellular, molecular and genetic mechanisms involved in building the brain is a fundamental problem in the neurosciences. Recent studies on brain development in the two leading genetic model systems, Drosophila and mouse, indicate that many basic molecular and genetic mechanisms involved in regionalization, neurogenesis and pathfinding in the brain are highly conserved. We propose to take advantage of the powerful genetic and molecular genetic technology available in these two model systems in order to develop and implement a novel and multi-disciplinary approach for the identification, characterization and manipulation of the genes that are essential for building complex brains. In Drosophila different regulatory control genes involved in brain development are now being characterised and evidence is accumulating that such genes play the role of master regulators for specific brain regions, including the visual system (e.g. Pax6/ey, Otx/otd) . Due to the sophisticated genetics and molecular genetics available in Drosophila, it is now possible within reasonable time limits to characterize the brainphenotypic effects of numerous additional candidate regulatory genes of this type, study the interactions among these genes, determine their downstream targets, and investigate their functional role through gene rescue and targeted expression. Moreover, given the evolutionary conservation of such master regulatory genes, the results of the investigations in Drosophila can be directly and rapidly applied to the developing mouse brain where homologous genes are already cloned, or can be rapidly cloned based on the knowledge gained in Drosophila. In the mouse system, spatio-temporal gene expression studies, gene knockout technology, and modern neuroanatomical tech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Back to the Future: Anticipatory synchronisation as a core mechanism for interarea brain communication' (BACK2FUTURE), addressing dissemination and exploitation.

assistant: **Impact**

Our brain processes multitudes of signals based on recurrent network activity involving feedforward and feedback interarea communication. To funnel information efficiently between areas, low-frequency rhythmic neural activity patterns couple to each other. It is an unresolved question how early sensory cortex (SC) can couple efficiently to both feedforward sensory information flow and feedback information flow arriving from higher order regions such as prefrontal cortex (PFC). Since PFC and sensory input lack direct coupling and operate with their own temporal dynamics, SC decouples from the sensory input when PFC couples to SC. It is therefore not possible to achieve efficient multi-area coupling in currently proposed feedback-driven coupling schemes. In search of a mechanism to address this problem I resort to a dynamical systems process called anticipated synchronization (AS). During AS, a receiving system (PFC) sends a copy of its own activity as delayed feedback to itself, allowing this system to - paradoxically - anticipate the dynamics of the driving system (SC). During AS, information from PFC is sent back to SC arriving at the right time in the future, while SC maintains sensory coupling. My goal in the next 5 years is to provide evidence of interarea AS coupling by creating a biophysical model of AS, empirically testing its predictions using ECoG data, psychophysics and EEG. By validating the use of tACS to control coupling, I will experimentally induce AS in a new closed-loop set-up that stimulates PFC with its own delayed activity. The proposed research will settle a critical theoretical debate on temporal coordination of interarea brain communication and will provide the computational basis for the hitherto unexplained excess of local feedback loops in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Modelling African Futures: A comparative technography of evidence-based welfare policy in Ghana, Senegal, Kenya and Botswana' (ModelFutures).

assistant: **Innovation**

Welfare systems rely on extensive knowledge about the population to plan, finance, and expend limited resources in a targeted manner. In view of their often-fragmented national identification and statistical systems, Africa’s emerging welfare states are thus facing significant challenges in their capacity to establish categories of welfare entitlement and to target groups for intervention. Led by the PI, ModelFutures’ team will carry out ground-breaking, comparative ethnographic research at the statistics-welfare nexus of four African country cases – Ghana, Senegal, Kenya and Botswana – to understand: How do states generate truths about future welfare in contexts of uncertain knowledge about the population and its wellbeing? The project’s threefold objectives aim to (1) trace statistical modelling practices in the context of multi-facetted uncertainties about the population and its environs; (2) analyse the impact of adaptations and creative data practices on quantitative truth claims; and (3) connect statistical future-making and anticipatory welfare politics in sites of statistical innovation. ModelFutures’ ambition significantly extends beyond the state of the art of our understanding of statistical world-making by developing a novel concept of vernacular prediction that attunes to experts’ skilful adaptations of globally circulating computational models and standards, while attending to their modelling practices’ co-constitution with symbolic commitments and situated infrastructural arrangements. Combining expertise from anthropology, science and technology studies, and population statistics, ModelFutures generates novel theory on the production of evidence-based welfare policies in contexts of contested claims to the validity of data, methods, and the anticipatory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Targeting GAB1: a novel therapeutic strategy for the treatment of leukemias' (LeukemiaBlock) targeting Horizon Europe.

assistant: **Abstract**

The emergence of therapy resistance and adaptation in acute myeloid leukemia (AML) remains a major challenge, leading to treatment failure and mortality. We and others have provided experimental evidence supporting novel idea that adaptation and resistance to therapy could be in early stages driven by signaling pathway rewiring, rather than genetic mutations. This project aims to advance our novel GAB1 inhibitors, targeting the adaptor protein GAB1- a key regulator of multiple signaling pathways implicated in therapy resistance. Within our past ERC StG grant “Signaling Propensity in the Microenvironment of B Cell Chronic Lymphocytic Leukemia” (2019–24), we demonstrated that GAB1 inhibition is effective in the single agent format, and also counteracts resistance in various hematologic malignancies, including highly aggressive AML (our US patent 11,648,255B2). Inhibiting GAB1 is particularly challenging due to its role as a docking protein, requiring innovative drug design distinct from conventional kinase inhibitors. This PoC project has five key objectives: (i) develop and patent a 2nd-generation GAB1 inhibitors, (ii) establish robust biochemical and biological assays for therapeutic evaluation, (iii) identify malignancies responsive to GAB1 inhibition and generate robust pre-clinical data, (iv) elucidate GAB1-mediated signaling modulation in cancer, and (v) assess market potential, formulate a business plan, and secure industry partnerships. Successful execution will enable further pre-clinical development of this docking protein inhibitor and facilitate clinical translation of our lead compound.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a very low-cost Interactive Graphical Tactile Display as advanced user interface for visually impaired' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The aim of TACMON2 is to develop an innovative technology for the low-cost realization of a large area Interactive Graphical Tactile Display as a computer periphery for visually impaired people, providing them a new dimension of access also to graphical oriented electronic information and to a wider range of PC applications. The proposed Graphical Tactile Display will consist of a fine matrix of tactile (haptic) accessible for the human touch sense, thus for visually impaired people. The concept of the cost reduction is the application of technologies, which allow the batch production of the actuator matrix on the surface without the need for individual assembly of actuators for each tactile dot.The TACMON2 technology is innovative in the combination of the applied technologies realizing an electrostatic pneumatic hybrid actuator system. A proof of concept has been successfully demonstrated based on silicon MEMS technology. The aim of the current project is a significant cost reduction by transferring the proofed concept from silicon base to LTCC (Low Temperature Co-fired Ceramics) based technology, as well as by developing a compact and integrated pneumatic support system realized in polymer technology.TACMON2 proposal intends to increase SME competitive advantage in the special needs sector by offering an innovative and cost-effective. There are 7.4 million visually impaired people in the European Union. High unemployment amongst the visually impaired is a serious social and economic problem for the EU. There is a need for effective assistive technology to facilitate employment of the visually impaired and for industry to better be able to meet anti-discrimination legislation, as well as to avoid the increasing exclusion from the increasingly visual/graphical oriented
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multi-phase Lattice Materials' (MULTILAT) targeting Horizon 2020.

assistant: **Abstract**

The integration of materials and architectural features at multiple scales into structural mechanics changed the way buildings were designed and gave us the Eiffel Tower, for example.  This approach led to the development of computational design approaches used in modern day construction and it is believed that similar principles can be applied to the design and manufacture of new lattice-based microstructures.  This vision, of fundamentally changing how materials are developed, is the inspiration behind this programme.  A systematic procedure for generating multi-phase lattice materials - MULTILAT - will be developed by micro-architectural design, in order to fill gaps in material property space.  New engineering devices and products frequently require materials with extreme properties, such as high strength and toughness at low density, and a systematic means of material invention is needed.  This proposal breaks much ground in developing new fundamental concepts, ranging from micro-architectured surface coatings to inter-penetrating bulk lattices of dissimilar materials.  Based on Fleck’s earlier work on the mechanics of foams and lattice materials, the unique and novel aspects of the proposed research are to design multi-phase lattice materials made from a wide range of materials, topologies and length scales.  The focus will be on 2 inter-penetrating lattices, but the topology of each can range from 1D fibres, through 2D meshes to 3D lattices and foams.  A focus will be lightweight strong and tough lattices, and surface lattices (as coatings).  Examples from Nature will be used to develop fundamental concepts, ranging from the high toughness and ductility of the root of a tree branch, to the high toughness of human skin and underlying fat. The successful project wi