RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'PRostate cancer OMics Oriented inTErvention' (PROMOTE) under Horizon Europe.

assistant: **Objectives**

PROMOTE focuses on multidisciplinary education of doctoral candidates (DCs) in -omics and artificial intelligence (AI) mediated intervention to improve clinical management of Prostate Cancer (PCa). PCa is the second most common malignancy, affecting ~1.3 million men every year worldwide. Tragically, there is a treatment paradox, as ~45% of PCa patients experience slow-growing cancer and are unlikely to progress rapidly, while PCa is not curable at advanced stage. Evidently, clinical management of PCa is not optimal, as patients which do not require treatment are over-treated, while for those that immediate actions are required, efficient treatment are still needed. To fill the above gaps, PROMOTE was formed to educate DCs in emerging -omics and AI technologies and deliver:a) novel non-invasive tools (based on biomarker- and AI- models) to guide intervention, andb) more efficient treatment options for advanced PCa (particularly metastatic) driven by molecular characterisation of the disease phenotypes.PROMOTE brings together 13 leading centers from different disciplines, including 3 SMEs, 4 university hospitals with clinical laboratories and 2 research institutes and 4 universities, closely collaborating with solid scientific background, as demonstrated by multiple publications. PROMOTE research builds on:i) available biobanks and -omics datasets within PROMOTE consortium, including >3000 urinary proteomics, >1100 imaging datasets paired with biopsy and pathology data, >350 paired RNA and proteomics urinary profiles, >100 tissue proteomics and ~300 phospho, proteo-genomic and transcriptomics profiles from public repositories,ii) established software and analytical protocols on -omics data integration, AI feature extraction and integration, systems biology, pathway enrich
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Potential role of the histonemethylase SMYD3 in myogenesis' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

SMYD3 is a histone methylase that di- and tri-methylates histone H3 at lysine 4. In normal conditions SMYD3 is highly expressed only in skeletal muscle and testis. We hypothesize that SMYD3 plays an important role in transcriptional regulation throughout myogenesis. We will use C2C12 myoblast and primary satellite cells as model systems to assess the contribution of SMYD3 to the transcriptional regulation of muscle specific genes. We will over-express and knock down SMYD3 to determine the impact of SMYD3 on the expression of myogenic markers and the ability of C2C12 cells to fuse into multinucleated myotubes. We will also determine functional mechanisms that account for a potential involvement of SMYD3 in myogenesis by employing chromatin immunoprecipitation experiments. Moreover, we will identify SMYD3 target genes in muscle cells by RNA microarray analysis and by the combination of the chromatin immunoprecipitation technique with massively sequencing technology (ChIp-seq). A further objective of the project will be to gain insights into the mechanisms underlying SMYD3 activity and its modulation, by exploiting in vitro and in vivo approaches.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Adaptation Futures 2016'.

assistant: **Objectives**

In 2016, the European Commission and the Government of the Netherlands will co-host the fourth edition of the International Climate Change Adaptation Conference, called ‘Adaptation Futures 2016’, with the initiators of the conference series, the Global Programme of Research on Vulnerability, Impacts and Adaptation (PROVIA). The overall objective of this action is to support the preparation and implementation of the 'Adaptation Futures 2016’ conference. The specific objectives are to contribute to the coordination of the conference planning, the overall and local organisation of the programme and venue, the participation of delegates from economically developed and less/least economically developed countries, and the organisation of an industrial exhibition.This proposal relates to the work programme's topic number 8 'International Conference 'Adaptation Futures' – The Netherlands, May 2016' in chapter 'Other Actions' of the revised HORIZON 2020 WORK PROGRAMME 2014 – 2015 for 'Climate action, environment, resource efficiency and raw materials', adopted on 10 December 2013 with a revised version for the 2015 topics (European Commission Decision C (2014)4995 of 22 July 2014).As stated in the work programme, The Ministry of Infrastructure and Environment of the Netherlands has been identified as a designated beneficiary of the grant to implement the coordination and support action. The ministry is experienced in organising international conferences of the scope and at the scale of the 'Adaptation Futures 2016' conference, as recently shown by the organisation of the Deltas in Times of Change II conference in Rotterdam in September 2014.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Non-relativistic effective field theories of QCD' (NREFT) under Sixth Framework.

assistant: **Objectives**

The project .deals with effective field theories ofQCD that describe physical processes where bound-state systems made of two heavy quarks, generically denoted as heavy quarkonia, are involved. There has been in recent years a huge progress in our understa nding of these effective field theories (NRQCD, pNRQCD,...), which may lead now to substantial advancements in the derivation of the heavy quarkonium phenomenology from QCD. This, going from spectroscopy to decay and production observables will be the main subject of the project. More specifically, we will try to improve our knowledge on weakly coupled heavy quarkonium states and have a better determination of some fundamental parameters of the Standard Model (the heavy quark masses and the strong coupling constant).. We will study decay observables, which will lead us to . fix non-perturbative and apos;matrix elements of QCD and better understand the behaviour of the perturbative serÿ­es. We will address the non-relativistic factorization in production pro cesses. Possible developments of the project also include heavy quarkonium properties in media and QED bound states. A program, which extensively deals with heavy quarkonium properties, seems to be timely in view of the huge amount of data produced recentl y and still expected by the experiments at BES, CLEO, B factories and Tevatron. The main part of the activities of the present project will be linked to those of the recently founded Quarkonium Working Group, which involves a large part of the physicists ( experimentalists, latticists, phenomenologists) working in the field in Europe, USA, China and Japan. This should help to keep the European scientific community working in the field strongly linked to the most advanced and competitive groups outside Europe .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Culture and management of scylla spp.' (CAMS), addressing dissemination and exploitation.

assistant: **Impact**

The proposed research aims to improve the reliability of hatchery and nursery production of mud crabs, providing seed crabs for development of mangrove- aqua salve culture systems, particularly in disused shrimp ponds. Hatchery-production will also support further development of stock enhancement to improve mud crab fisheries in mangroves. Detailed fisheries and population studies will determine recruitment and productivity in crab fisheries in established and replanted mangroves, supporting selection of Scylla species for stock enhancement and comparison of the cost-benefits of stock enhancement and habitat rehabilitation as strategies for improving crab fishery yields.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Automated evaluation and correction of generation bias in immune receptor repertoires'.

assistant: **Innovation**

Personalized medicine is promising to change the health and prophylactics sectors, already showing large societal and economic impact. High throughput immune sequencing technologies give us insight into a unique personal medical record - our immune system’s memory of all encountered infections and the successful solutions our body found. Unfortunately, reading this record requires advanced statistical tools making it often inaccessible to biologists and medical practitioners. PGEN offers a solution that will fill this gap between modern technology and applications by developing commercialisation solutions for an immune repertoire analysis software. PGEN builds on the methodologies developed during the ERC Starting Grant RECOGNIZE to provide a user-friendly versatile software prototype that will give researchers in the life scientists and medical practitioners without bioinformatic training an overview of the statistical properties of the immune repertoires they are studying. PGEN will explore the impact on medicine and biotechnology of this software platform that identifies non-standard immune responses that can be exploited in vaccine design and novel personalised therapies. Currently no software exists that a medical practitioner can use to characterize the baseline immune repertoire of a healthy person. Knowing this baseline is essential for identifying immune system disfunction and applying immune repertoire sequencing technologies in biotechnology and medicine. The PGEN software platform will provide doctors and biologists with a statistical tool that will help them make informed decisions about treatment, prophylactics and future research. PGEN will pursue commercialization and market solutions both within academia, the biotechnology and medical sectors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'INNOVATIVE PVD NANO-COATINGS ON TOOLS FOR MACHINING TITANIUM AND NICKEL ALLOYS' in the context of a Sixth Framework call.

assistant: **Objectives**

The aim of this project is the substantial improvement of cutting tools for the machining of nickel and titanium alloys. These alloys present several problems during machining operations, and as a result today there are important restrictions regarding tool performance that limit the economy and quality of the final parts. The most important fact is the trend to work harden, due to the localized overheating, and stick or adhere to the cutting tool surface. Therefore, tools with sharp edges, with a very good surface finish and low chemical affinity are required. The application of selected PVD nano-structured coatings with a thickness of less than 1 micron can improve the cutting tools without worsening at all the sharpness, making it possible that the Ni & Ti machining benefit from a technology that has already been successfully applied to machining other materials, i.e. steel alloys, but has showed little if any improvement in Ni & Ti. A PVD nano-structured coatings can decrease friction (lower overheating risk) allowing higher machining speeds or even avoiding the use of lubricant. Furthermore, a hard nano-structured coating with a nano-thickness can be applied to the tool maintaining its surface finishing and sharpness, thus delaying the presence of local wear defects; this will reduce material sticking and increase tool life. The objectives of the project will thus focus on i)longer cutting tool life ii)faster machining and iii)a reduction/elimination in the use of lubricants and coolants. This will translate into more economic Ni and Ti made parts, which are directly related to social targets widely assumed as not only important but mandatory by the European society: A)Sustainable development: more efficient use of energy resources as efficiency in power generation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ecos 2002: international conference on efficiency, costs, optimization, simulation and environmental impact of energy systems (INCO A1)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

ECOS 2002, the 15th International Conference on Efficiency, Costs, Optimisation, Simulation and Environmental Impact of Energy Systems will provide scientists and engineers from academia and industry with a forum to present their recent findings on the design, management, analysis, economic performance, environmental assessment, and optimisation of energy systems. Conference participation support for researchers from states in the phase of pre-accession to the European Union will promote the development of scientific networks among researchers from candidate countries and member states working in the field of energy research. This in turn would facilitate their participation in future joint projects and concerted actions aimed at achieving cleaner energy systems. As a consequence, the measure should increase both the quality of energy related research and the environmental performance of current energy systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Green mobile recycling technology for dirty (none-recyclable) plastic waste' (MobileRecycle) under Horizon 2020.

assistant: **Objectives**

The plastic waste is a serious problem for all over the world due its non-biodegradable character. Global problem of the plastic waste is in its limited recycling. On average, Europe produces 25, 2 million tonnes of plastic waste every year. 37% of the plastic waste ends up in landfills, 25% is recycled and 15% is composted. Only 23% is used for energy production. European economy thus loses a significant amount of potential 'secondary raw materials' among which plastic plays a significant part.The Leitner will introduce to the market a green method of recycling dirty plastic waste applicable on a global level and the result of the recycling is alternative fuel (oil and gas). The equipment recycles dirty plastic waste by thermal depolymerisation, thus recasting it into ecological oil and process gas with immediate further multi-purpose usage. Leitner is a mobile technology, suitable also for small operations optimally processing 1 thousand tonnes of dirty plastic waste per day. The applicant has produced prototypes of the green technology and has tested them now in industrially relevant environment (real operation). The equipment weight is 2,500 kg, forming a container assembly (dimensions: 8m x 3m x 3m), which can be easily connected/disconnected. The existing prototype produces 1 litre of oil from each kilogram of dirty plastic waste. For the production of 1 litre of an ecological oil, the technology requires 1 kWh energy. The project intention is in line with EU endeavours to support SMEs in areas addressing the climate action, environment, green growth potential and raw material challenge. The project is also in line with 2016-2017 strategic priorities of systemic eco-innovation and circular economy, nature-based solutions and sustainable supply of (secondary) raw m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'METAL TOLERANT ECTOMYCORRHIZAL FUNGI : SELECTION, CHARACTERIZATION AND ITILIZATION FOR RESTORATION OF POLLUTED FORESTS' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

This project is dedicated to contribute to the protection and restoration of metal polluted forests by the utilization of symbiotic fungi. However the use of ectomycorthizal fungi as management tools requires further, more detailed studies of the fungi occurring naturally in such environments and of the processes involved in detoxification.The proposed project addresses four central problems:- the selection of tolerant ectomycolthizal species by screening of polluted forest soils and increased understanding of the extent of inter- and intra-specific variation.An inaculum bank of ectomyconhizal fungi adapted to polluted conditions will be created which will include strains with various types of tolerance. An important aspect of the project is the use of ectomycolthizal fungi asbioindicators of metal pollution by determining the concentration of metals in fruitbodies.- the investigation of the mechanisms underlying the remediative effects of symbiotic mycorthizal associations on metal toxicity to trees. There is clearly a need for selecting biochemical markers of metal tolerance in ectomycorrhizal fungi.- the selection of combinations of tree and fungal symbiont suitable for restoration of metal polluted sites. In this project the ability of species and strains of ectomycolthizal fungi to improve the metal tolerance in symbiosis will be investigated at the laboratory level with a range of tree/fungal symbiont combinations. When lauge scale cultivation of varieties of trees inoculated with a metal tolerant ectomycorthizal strain will be possible, then restoration of contaminated areas would become a reality.- the transplantation of mycorthizal trees in impacted forest soils and the detection in the soil environment of the introduced fungi to determine their survival, growt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The most viable stationary energy storage solution for grid applications' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Increasing share of renewable energy (solar and wind) into the EU energy mix is posing new grid management problems for operators. As the share exceeds 25%, it causes high levels of grid instability that can lead to supply insecurity and outages. As a result, EU electricity distribution operators will require €480 billion by 2035 to expand their networks to overcome challenges associated with integrating renewables if cost and service life of current energy storage technologies are not improved. The only two energy storage methods that have acceptable cost and life: pumped hydro-storage (PHS) and compressed air energy storage (CAES) do not have the required rapid response times and are severely limited by geographic restrictions. While battery energy storage (BES) systems have the required instantaneous response, current technologies are prohibitively expensive and have limited lifespans and have safety risks.In response to this, Greenvolt Nanoma ehf, an Icelandic company uses nanotechnology to develop the first ever BES technology to meet all performance and cost criteria for grid applications. Our Nano-Edison battery’s costs and service life are comparable to PHS and CAES. Our solution is also tolerant to heavy currents, overcharging/discharging and even short circuits and can support pulse charging – making it ideal for capturing variable renewable energies.As such, we have a unique advantage within the rapidly growing €7.34 billion global market for grid-scale battery storage. With a viable technology that enables grid operators to defer investments in costly network expansion, we seek to be the global leader in energy storage for stationary applications. We have estimated that we will need an additional investment of €3.5 million to achieve that and bring our techn