RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Defining the genetics of grapheme-colour synaesthesia' (SynGenes).

assistant: **Concept**

Synaesthesia is a common neurodevelopmental phenomenon (2-5% of the population) where stimulation of one sense automatically triggers an experience of another. Familial clustering indicates that synaesthesia is highly heritable. However, this genetic contribution is poorly understood and likely heterogeneous, a major hindrance to our understanding of the neurobiology. My objective is to remove this barrier through the most comprehensive interrogation of synaesthesia genetics to date, utilizing state-of-the-art technologies and integrative approaches.This study will focus on individuals who associate letters and numbers with colour (grapheme-colour synaesthesia), as this type of synaesthesia is common and the most reliably measured. I will apply two complementary approaches in parallel. Whole genome sequencing in two newly ascertained multigenerational synaesthesia families will determine the role of rare genetic variants (Work Package 1, WP1), while genome-wide genotyping of 1000 unrelated synaesthetes will unmask contributions from common variation (WP2). Using existing candidates and novel genes discovered in this work, I will perform multi-level in silico analyses to test if genetic information supports the prevailing theory of neural hyperconnectivity as an underlying aetiology (WP3). WP1-3 will help to define the genetic landscape of synaesthesia, while opening novel research avenues into the neurobiology of sensory perception.This fellowship will provide a diverse set of stepping-stones toward my professional goal of becoming an independent researcher in the rapidly advancing field of neurogenetics. The research and training plans will deepen my current skillset and add a suite of complementary informatics skills that will significantly enhance the quality and com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Additive Printing for Cell-Based Analysis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The Project shall develop a unique manufacturing solution for the automated production of complex cell models widely used by industry to test biological activity and biosafety. No means of scalable manufacture presently exists. The technical solution is to assemble cell models by additive manufacturing; to control the resident cells’ locations within these 3D models; to supply the models to customers as pre-assembled, frozen products. The result shall be an analytical tool which, unlike current practice, does not compromise analytical output for convenience, but combines high predictive value and low cost with exceptional user-friendliness. The solution is unique, proprietary and highly positive-disruptive in its industrial sector. Its achievement will be measurable in this Project as an exemplifying, printed hepatotoxicity assay with wide application in drug discovery and biosafety testing. An SME Instrument Phase 1 Project advanced the core printing technology delivering this solution to TRL7, and developed a business plan for its exploitation. That business plan confirmed the wide, cross-industry application of cell-based analysis, from preclinical drug discovery through natural products/food to medical devices and nanosafety, and mapped the advantages of additively-manufactured products onto demonstrable industry trends and customer needs. The business plan and its underpinning technology are founded in the applicant’s long-term strategic goals, evidenced by profitable business in the target market from proprietary cell-based services, and by ancillary technology developments, also to TRL7 and supported by UK national funding, which create unique competitive advantage. The outcome of this Phase 2 Project will be a mature cell-based manufacturing technology, its demo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Protecting biodiversity in the face of climate change' (PROTECTINGBIOFACCTS).

assistant: **Concept**

Human-induced land use changes are causing extensive habitat fragmentation. As a result, many species are not able to shift their ranges in response to climate change, and will need to adapt to changing conditions. A prudent strategy to maximize the evolutionary potential of populations is to focus conservation efforts on areas where levels of intraspecific variation are high. Recently, I proposed a novel approach to integrate evolutionary processes with traditional prioritization strategies, using spatially explicit models of intraspecific genetic and phenotypic variation. The next crucial step in the further development and refinement of the framework is to understand its general utility. The objectives of this project are to: 1) measure morphological characteristics and genotype 10 common species each in Bulgaria/Romania and Cameroon; 2) map the spatial patterns of intraspecific variation in these regions; 3) prioritize areas for conservation based on intraspecific variation versus species richness; 4) measure the effectiveness of intraspecific variation in one species as a surrogate; 5) compare the overlap in reserves based on either intraspecific variation or species richness; 6) compare the utility of coding versus non-coding genetic markers. The deliverables will be: 1) maps identifying areas with high amounts of intraspecific variation, 2) insight into the general applicability of our approach, 3) a better understanding of the relationship between biotic and abiotic diversity, 4) insight into the effects of neutral and selective processes on population divergence, 5) further understanding of how environmental variation shapes divergence in neutral and adaptive loci, 6) a toolbox of methods for use by conservation planners. This project will greatly enhance the i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'FInding ExoeaRths: tackling the ChallengEs of stellar activity' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

FIERCE aims at providing the long-needed step forward to tackle the challenges of stellar activity on the search for Exoearths.The detection and characterisation of other Earths, planets with the physical conditions to hold liquid water and thus potential life-sustaining environments, is a bold objective of present day astrophysics. This goal continuously pushes the development of new ground- and space-based instrumentation. However, the quest for other Earths is severely limited by astrophysical ``noise'' from the host stars, whose signatures distort the spectra that are used to detect and characterise them. Existing methods usually circumvent the problem without a detailed understanding of the individual sources of variability. This is insufficient to reach the required precision levels. To enable the full scientific success of major exoplanet research facilities a new approach is clearly needed.With FIERCE, the PI will employ his competitive team, together with the strong participation in cutting-edge ESO and ESA projects and missions, to break through in this obstacle. The ultimate goal is to i) develop novel approaches to identify, model, and correct stellar spurious signals in radial velocity measurements down to 10 cm/s, and ii) obtain a comprehensive understanding of the impact of stellar granulation and activity on the detection of exoplanet atmospheres.To this end, FIERCE will approach the problem of stellar ``noise'' from a whole new angle, building a dedicated facility, the Paranal solar Espresso Telescope (PoET). PoET will connect to the recently commissioned ESPRESSO spectrograph and, using the Sun as a proxy, allow to unambiguously identify and understand the sources of relevant variability in solar-type stars.Ambitious, timely, and feasible, this project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'IMAGINE climate change adaptation in urban areas' in the context of a Horizon Europe call.

assistant: **Objectives**

Impacts of climate change are happening as a result of extreme temperatures, sea-level rise, storm surges or droughts. Communities and governments across the globe are preparing through actions to increase climate resilience. However, progress made to date to adapt is still poorly understood and tracked due to a lack of theoretical understanding and means to evaluate how well the world is adapting. Further barriers are unclear goals and metrics for adaptation in the absence of a shared definition of successful adaptation. Finding a response to this question is at the core of the international climate debate and has particular significance at the local level where assets and lives of millions of people are at risk.'IMAGINE adaptation' addresses the imperative of how to evaluate adaptation in urban areas as a contemporary complex phenomenon with implications across governance scales. The current focus on policy progress can be useful as a first step, but it is not indicative of effective adaptation. A broader understanding of success in adaptation is required: one that transcends technocratic approaches and considers equity, justice and maladaptive issues.Through 'IMAGINE adaptation', I aim to respond to four timely and ambitious objectives: First, I will revisit and reformulate the concept of successful adaptation using expert and local views (Objective 1, O1). Second, I will explore trends and needs regarding monitoring and evaluation and how these may enable or hinder adaptation (O2). Third, I will participate and learn from local adaptation evaluation practices through a comparative case study research across 12 urban areas worldwide (O3). Finally, I will discuss how evaluations of local progress can inform global goals (O4). The outputs of this project will be a refe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Visualizing microbial societies: exposing the principles of single-cell phenotypic heterogeneity via massively multiplexed imaging' (SocialBugs) targeting Horizon Europe.

assistant: **Abstract**

Bacteria are social organisms that interact and coordinate their behaviors to shape our world. Whereas their clonal populations are genetically identical, they contain phenotypically distinct members. This diversity provides resilience to unpredictable environmental changes, such as antibiotic exposure or nutrient depletion. It also facilitates cooperative interactions between different sub-population via specialization in costly activities such as virulence factor production, forming an extended basis for sociality. Yet, the phenotypic landscape in any given species remains largely unexplored due to the technical challenges of profiling individual bacteria, particularly in spatially structured biofilms and host tissues. Recent breakthroughs in microbial single-cell transcriptomics, developed by the PI of the current proposal (Dar et al., Science 2021), now provide a unique opportunity to illuminate this hidden complexity.This proposal seeks a systematic and experimentally derived view of phenotypic variation. We will comparatively study pathogenic and non-pathogenic Pseudomonas species in three settings, each illuminating distinct core principles of cell-cell variability. In Objective 1, we will focus on free-living populations, building on the massive multiplexing capacity of our method to comprehensively map phenotypic cell states, outline their interplay with physiological and environmental factors, and study their evolution. We will characterize the spatiotemporal dynamics of cell states directly within 3D biofilms in Objective 2, and contextualize our results in vivo during infection in Objective 3, simultaneously measuring host-and-microbe spatial expression.Comprehensively studying phenotypic heterogeneity is a critical next step for understanding how microbes s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Platform for Integration of Trans regional Energy R&D activities' to be submitted under Seventh Framework.

assistant: **Abstract**

The project aims at creating a trans-national platform to facilitate the exchanges between the members of the consortium in terms of: research, technological development and transfers, joint political and economical actions for the development and diffusion of renewable energy. This project contributes to the implementation, at a local and national level, of the European directives concerning a better and more efficient use of alternative sources of energy and the reduction of CO2 emissions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'European ROBotics and AI Network'.

assistant: **Concept**

As robots are entering unstructured environments with a large variety of tasks, they will need to quickly acquire new abilities to solve them. Humans do so very effectively through a variety of methods of knowledge transfer – demonstration, verbal explanation, writing, the Internet. In robotics, enabling the transfer of skills and software between robots, tasks, research groups, and application domains will be a game changer for scaling up the robot abilities.euROBIN therefore proposes a threefold strategy: First, leading experts from the European robotics and AI research community will tackle the questions of transferability in four main scientific areas: 1) boosting physical interaction capabilities, to increase safety and reliability, as well as energy efficiency 2) using machine learning to acquire new behaviors and knowledge about the environment and the robot and to adapt to novel situations 3) enabling robots to represent, exchange, query, and reason about abstract knowledge 4) ensuring a human-centric design paradigm, that takes the needs and expectations of humans into account, making AI-enabled robots accessible, usable and trustworthy.Second, the relevance of the scientific outcomes will be demonstrated in three application domains that promise to have substantial impact on industry, innovation, and civil society in Europe. 1) robotic manufacturing for a circular economy 2) personal robots for enhanced quality of life 3) outdoor robots for sustainable communities. Advances are made measurable by collaborative competitions.Finally, euROBIN will create a sustainable network of excellence to foster exchange and inclusion. Software, data and knowledge will be exchanged over the EuroCore repository, designed to become a central platform for robotics in Europe.The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MECHANISMS OF HEPATITIS C VIRUS ENTRY IN POLARIZED CELLS' to be submitted under Seventh Framework.

assistant: **Abstract**

Hepatitis C poses a global health problem. Hepatitis C virus (HCV) infects over 170 millions individuals worldwide with the majority remaining undiagnosed and untreated. To this day, there is no vaccine and the available treatment, a combination of ribavirin and pegylated α-interferon has a limited efficacy and important side effects. A better understanding of HCV life cycle will unravel target for new potential therapeutics. In recent years, the knowledge concerning hepatitis C virus (HCV) entry inside the cells has improved, suggesting a complex mechanism involving several (co)receptors. All the studies regarding HCV entry have been performed in non polarized cells, however HCV infects primarily hepatocytes that are highly polarized cells with a complex organization. Polarized cells have two separate membrane domain, the apical and basolateral domain, with different functions and molecular composition. Separation of the two domain is achieved by complex and tightly regulated intracellular trafficking. Tight junction proteins, which play an essential role in cell polarization, figure in the different molecules involved in HCV entry. This suggests that cell polarity might be relevant to HCV entry and probably add supplementary constraints on HCV entry. In this project I therefore propose to study the mechanisms of HCV entry in polarized cells. To develop this project, a model of polarized hepatic cells will be established and used to investigate the specific roles of entry factors, the intracellular trafficking of the virus, the role of cytoskeleton in HCV entry and the dependence on signaling to mediate entry. The data generated in this project will shed new light on a complex and tightly regulated process. Importantly, studying entry in polarized hepatocytes should al
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mediators of Inflammatory in Asthma' (1994-1998).

assistant: **Innovation**

Asthma is a complex inflammatory disease driven by a network of inflammatory mediators, including lipid mediators, cytokines, neuropeptides and nitric oxide. The mechanisms of increased mediator production in asthma are not well understood. Our primary objective is to elucidate the mechanisms involved in increased mediator production in asthma in order to understand the pathophysiology of this increasingly common condition and to lead to the development of new and more specific therapies. We have adopted a multi-disciplinary molecule-to-man approach as the questions and scope of the research is complex and needs to involve several groups. We have brought together leading European research groups in the field of inflammatory mediators to address this objective. Major research tasks include elucidation of the factors that regulate expression of lipid mediators (leukotrienes, prostaglandins and platelet-activating factor) and their receptors in airway and inflammatory cells, experimental models of asthma and in normal and asthmatic airways. We will also study regulation of expression of lymphokines and chemokines that orchestrate eosinophilic inflammation in asthmatic airways, sensory neuropeptides and their receptors and the enzyme that generates nitric oxide, using the same approaches. Establishment of a network of investigators will allow us to study the interactions between different mediators, by taking advantage of the different assays and technologies available amongst the partners. A unifying theme to this project is the idea that there are common molecular mechanisms leading to increased expression of the genes responsible for the synthesis and effects (receptors) of multiple inflammatory mediators. For example, pro-inflammatory cytokines increase the expression o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Social media and resurgent ethno-nationalism in Greece' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The role of the media in the rise of political extremism is a critical issue for European societies in the current political and economic crisis, the persistence of which seems to foster euroscepticism, nationalism and right-wing populism. Greece is a highly emblematic case in this context, since the spread of anti-European sentiment, in addition to high poverty levels and the unprecedented rise of political extremism, pose a threat to the very survival of democracy. Since the beginning of the crisis, news stories in printed and electronic media in Greece have been dominated by negative emotional connotations: rage, fear, distrust, depression. The 2012 elections came to confirm these tendencies, the most disturbing of which is the electoral result achieved by the neo-Nazi Golden Dawn. In less than three years the right-wing extremists managed to increase their vote by more than twenty times, despite their anti-parliamentarian, racist and nationalist stances and violent means of action.This wave of political extremism is an important phenomenon, yet there seems to be a significant knowledge gap in the field. Perhaps the least analyzed aspect is how the influence of the media determines its course. This project brings together a talented, young political researcher, experienced in political organizations and media communication, to work with an international team of experts in media studies and sociopsychology, in a two-fold study. At a macro level, we seek to examine the way that Greek media and public debates have formed negative emotions and perceptions on how democracy works, and to decode the mechanism through which such emotional stocks might have functioned to create a political opportunity for extremists in the context of the crisis. At micro level, we aim to prof