RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The function and dynamic of cholesterol during Plasmodium liver stage infection' in the context of a Seventh Framework call.

assistant: **Objectives**

Plasmodium parasites are the causative agents of malaria, amongst the most prevalent and severe human infectious diseases. Liver infection by Plasmodium sporozoites is the first obligatory step of malaria and a quite attractive target for prophylactic strategies against the disease. At this stage, each sporozoite invades a single hepatocyte and develops into thousands of merozoites that are released into the bloodstream. Preliminary results of the host laboratory clearly show that a hepatocyte receptor, SR-BI, plays a crucial role both in invasion and development of Plasmodium in the liver. In its physiological role, SR-BI is a central component of the cholesterol uptake by cells. Thus, the overall aim of this project is to reveal whether and how cholesterol uptake by SR-BI is critical for hepatocyte infection by Plasmodium. By using various cell biology approaches, we propose to: 1) describe the chronology of cholesterol requirements during the infection, 2) investigate the SR-BI and cholesterol organization and dynamic at the sporozoite-host cell interphase and 3) determine the role of SR-BI in delivering cholesterol for Plasmodium development inside hepatocytes. Achieving this plan of work will, hopefully, provide a rationale for a potential SR-BI/cholesterol-based anti-malarial prophylactic intervention, and contribute to the European excellence by reaching one of the main goals of the 7th Framework Programme regarding Action to Confront Infectious Diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Uncertainty Visualization for Reliable Data Discovery' (SAFERVIS), addressing dissemination and exploitation.

assistant: **Impact**

Visualization has significantly changed the way humans analyze large amounts of multi-dimensional data. However, current visualization techniques can give only little or no guarantees regarding the confidence in the displayed information. Since this information is always affected by uncertainties in the data generation and visualization processes, the user can be lead to misclassifications, misinterpretations, and false assumptions.This proposal challenges the status quo in visual data analysis with innovative ideas for next-generation technology that provides uncertainty visualization as a core methodology. We will develop a visual language for the communication of the variability of features due to uncertainties in the data generation and visualization processes. Our research aims at modeling the uncertainty stochastically and deriving probability distributions for the occurrence of features. Especially in 3D, finding meaningful visualizations of the effect of uncertainty is extremely demanding and requires going far beyond existing approaches.Besides radically changing the way visual data exploration is performed, our research has the potential to strongly influence the way scientific measurements and computer simulations are carried out. The precise knowledge of uncertainties enables to discover quantitatively the data generation process, and it can, therefore, be used to quantify the sensitivity of a process and the generated results to the choice of parameterization over the input parameters. Hence, it is our second vision to position uncertainty visualization as a future technology for guiding research towards the most reliable data generation process within a given uncertainty tolerance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Beyond cynicism and bare life: practices of citizenship against migrants' inclusive exclusion' in the context of a Seventh Framework call.

assistant: **Objectives**

The proposed research addresses themes of current social relevance, such as the politics of migration and its governance, and their relation to emerging forms of engaged citizenship and sovereignty. The researcher shall investigate ethnographically modes of protest and solidarity that seek to contrast states' regulation of migrant movement (with a special focus on detention and deportation), and labour regimes based on the disposability of migrant bodies in contemporary Europe. Forms of resistance and flight are widespread across different EU countries, and take the form of attempted escapes from detention centres, hunger strikes, dirty protests, the sowing of one's lips, and episodes of self-harming, as well as labour strikes and dramatic acts that capture media attention, such as the occupation of rooftops and the climbing of cranes. Anti-racist solidarity networks are also active in supporting undocumented migrants, through demonstrations, boycotts, and the provision of alternative media coverage on the issue.The research will take Italy as the main research location, but a comparative perspective will be brought into the project by creating an interdisciplinary research network gathering scholars who work on related issues across Europe. The project will investigate the relationship between subjective experiences of migration, detention, protest and solidarity, in the light of multiple historical trajectories and personal narratives. Affective and intimate relations will be explored together with the workings of institutions and structures of power, their limitations and possible alternative modes of sociality.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Epistemic Utility for Imprecise Probability', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Scientific inference is principally a matter of using observable data to estimate the parameters of models of interest, e.g., models of the climate system. In traditional Bayesian statistics, uncertainty about model parameters is quantified using a single, precise probability distribution. This approach has proved extremely successful in applications where data is plentiful and model parameters are few. But many models are high dimensional (thousands of parameters), and relevant data is comparatively sparse. In such contexts, imprecise probabilities are required to adequately capture uncertainty. The mathematical foundations of imprecise probability theory (IP) have been in place for 25 years, and IP has proved successful in practice.  But IP methods lack rigorous accuracy-centered, philosophical justifications. Traditional Bayesian methods can be justified using epistemic scoring rules, which measure the accuracy of the estimates that they produce. But there has been little work extending these justifications to the IP framework. Thus, the key aim of the proposed research is to develop scoring rules for IP distributions (IP scoring rules), and use them to justify and extend IP methods. There are four main objectives: (1) characterise reasonable IP scoring rules; (2) derive scoring-rule based justifications for existing IP methods; (3) use IP scoring rules to discover novel methods for selecting and updating IP distributions; (4) use IP scoring rules to engineer new deference and aggregation principles for IP distributions. Objectives 1 and 2 will deliver firm foundations for existing IP methods. Objectives 3 and 4 will extend the range of IP methods available for both individual and group inquiry. The results of this project will not only make IP a central focus in con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'TELEMATICS FOR TEACHER TRAINING' (T3) targeting Fourth Framework.

assistant: **Abstract**

This project will boost the take-up of telematics by school and university teachers or trainee teachers in the EU, with an emphasis on the promotion of lifelong learning. Courses run by a university and business consortium will enable multi-lingual multi-cultural refinement of good practice in teaching mathematics, languages, science and technology. As teachers develop their own telematics skills they will be encouraged to explain to their students how to use the technology to teach themselves. Similar courses for teacher trainers and guidelines for library staff will be validated by ministries and professional associations.The Telematics for Teacher Training project will encourage over 4,000 teachers to adopt telecommunications and new technologies in schools and universities across the European Union. It will establish courses for teachers within a growing consortium of universities and commercial services, which will continue to develop beyond the millennium.Primary and secondary teachers, their teacher trainers and library staff will develop new practices together enhancing the quality of learning and knowledge of Europe within the curriculum. Best practice will be refined for teachers of mathematics, languages, science and technology in several European languages and many cultures.T3 will focus on supporting the new approach to education and training within the European Union: lifelong learning. Teachers will model this practice in front of their students. Teachers' skills in both Telematics applications and in tutoring students how to learn for themselves will be available, even in remote rural areas, with the use of new technologies.Universities in Finland, France, Ireland, Italy, The Netherlands, Portugal and the UK form the consortium with support from partners
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of brain-permeable masked nanobody-drug conjugates to eliminate glioma stem cells' (ADC2GBM), addressing dissemination and exploitation.

assistant: **Impact**

Glioblastoma multiforme (GBM) is one of the most prevalent brain tumours and is currently incurable. Patients die from tumour recurrence after resection and chemotherapy. New treatments need to overcome two great challenges: reaching the tumour margins, where the blood-brain barrier (BBB) is intact, and eradicating glioma stem cells (GSCs), which cause tumour relapse. Targeting receptors overexpressed on cancer cells with antibody-drug conjugates (ADC) has shown great promise in cancer treatment. However, most receptors on GSCs are also present in normal stem cells. Thus, targeting these receptors with antibody-drug conjugates may lead to severe side effects. The main objective of this proposal is to develop a masked nanobody-drug conjugate with the capacity to overcome the BBB and to be activated only in the tumour to selectively target GSCs. Nanobodies have increased capacity to penetrate tissues and biological barriers but none is yet available to target the GSC marker CD133. Therefore, I will generate new nanobodies against this receptor. Subsequently, I will set up a phage display platform to develop masked nanobodies that can be selectively unmasked by tumour proteases. The masked nanobody will be conjugated to a drug and then to a BBB-shuttle peptide. A panel of conjugates will be screened in vitro for target selectivity, efficient activation and BBB transport. Finally, the efficacy of the most promising candidates will be tested in a GBM mouse model. Our unique combination will generate the first bispecific nanobody-drug conjugates targeting GSCs to treat GBM. The concept of GSC-targeting with activatable ADC may change the current paradigm for the treatment of brain tumours. Furthermore, our workflow may be applied to dramatically enhance the efficacy of other
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Mathematical Foundations of High-Quality Terrain Models'.

assistant: **Objectives**

A digital terrain model is a representation of a real-world terrain in a computer. Terrain models play an important role in geographic information systems, where they are used for numerous purposes, like path planning, visualization, and terrain analysis. One of the main ways to represent a terrain is by a triangulation: some points are sampled from the real terrain, and they are connected by triangles that cover the whole terrain area. This results in a subdivision into triangles. There are many ways to triangulate the points, and choosing the right one is essential to obtain terrain models that represent the real terrain faithfully. In particular, the shape of the triangles is very important: long and skinny triangles should be avoided. However, that is not enough. The current approach to triangulating terrains does not take the elevation of the points into account. This can create artifacts---like spurious pits, interrupted valley lines and artificial dams---, a serious obstacle for performing terrain analysis tasks, especially for hydrology or erosion simulations. This research will study combinatorial and geometric properties of triangulations, in order to design new automated methods to find triangulations with well-shaped triangles and---at the same time---as few artifacts as possible.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Optical technology for intelligent monitoring on-line' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

OPTIMO concerns the definition and control of quality in the production of water for human consumption and in the production of blending of wines. In the water industry, on-line colour measurement is the principle parameter driving the treatment process (coagulation) and in the wine industry, colour is used to define wine type, to control blending and to monitor the quality. However, in both of these industries in-process colour measurement is adversely influenced by the presence of suspended particles (turbidity, haze) and this leads to inccurate definition and inefficient control of product quality.The objectives of the project are to enable (i) more accurate definition of on-line water quality and of wine quality and hence better correspondence between on-line and off-line quality measures as defined by National and EU regulatory imperatives, (ii) more efficient control of the water treatment process (coagulation) at lower cost by saving on raw materials and man power, (iii) more efficient control of the wine production and blending process at lower cost by saving on raw materials, reduced intervention and man power, and to improve the accuracy of environmental sediment and pollutant transport studies in general.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Time-resolved sImulations of ultrafast phenoMena in quantum matErialS' (TIMES) targeting Horizon Europe.

assistant: **Abstract**

Emergent phenomena arising from excitation, correlation, and coherence of electrons, spin, photons and nuclei may open unexplored paths to exploit advanced quantum materials. Modelling and understanding ultrafast non-equilibrium dynamics is the key to quantum computing, to new paradigms for information storage and retrieval, to novel opto-electronic devices for efficient light emission and renewable energy production, and to efficient single-photon quantum emitters. The TIMES doctoral network will merge different areas of expertise in many-body and time-dependent electronic structure methods to define a new paradigm for the atomistic modelling of nonequilibrium processes in condensed matter. This is an area where the theoretical state-of-the-art is lacking in predictive power. On one hand modeling crucial dynamical processes such as the ones involving energy exchange between electronic and nuclear degrees of freedom out-of-equilibrium remains out of reach for current first-principles approaches. On the other hand, phenomenological and second-principles models lack the granularity required to quantitatively capture the evolution of complex materials.TIMES will develop first-principles theoretical and computational tools to tackle the coherent and correlated electron-nuclei dynamicsstimulated by ultrafast laser pulses for the understanding of complex quantum states and emergent phenomena in a diverse range offunctional materials like perovskites, 2D materials, Weyl semimetals, Dirac materials and topological insulators. For this purpose,TIMES will train a new generation of scientists capable of devising novel theoretical and computational frameworks to simulatenonequilibrium phenomena. TIMES will synergize theoretical and numerical developments with High Performance Compu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Fun, Healthy and Safe Finger Food for Babies and Children' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In 2010, 1 in 3 European children aged between 6-9 years old were overweight or obese – increasing from 1 in 4 ratio by 2008. Obese and overweight children are more likely to grow obese or overweight adults. It is estimated that obesity has about 7% impact in the national health budgets, across the EU.  Childhood is an important time to instil a preference for healthy behaviours.We have developed the first vegetable-based finger food for babies and children. Made of organic vegetables cooked below 100 °C, with no additives, no added sugar and no allergens, our product is as good as homemade food.  Vegetable-based finger foods for babies and young children have several advantages: i) helps developing healthy taste habits – parents often struggle with babies and children to eat their vegetables; ii) babies and children can grab it with their hands, which is fun, promotes autonomy and develops motor skills; iii) it replaces junk food and can be served as a meal or as a snack.We target parents who are often too busy to prepare a special meal for their babies or children. In general, these parents are rather urban and active searching for practicability and time saving. We expect to have a major impact for parents who have babies or children with special diet requirements due to health issues, such as overweight, diabetes or food allergies.The baby food market was valued at €43bn in 2017, from which €8.6bn correspond to prepared baby food. The organic baby food market represents about 15% of the total baby food market and is projected to grow with a 12 % CAGR forecasted in 2017-2025.We are aiming to start scale up of our technology in 2019, targeting €16m in revenues by 2022 with 23+ FTEs. In this Phase 1 project we will investigate the new target market segments & develop a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'AppIOS: Platform for Building Next Generation Enterprise Software' (AppIOS).

assistant: **Concept**

Our innovation project is developing and delivering tools and a platform for building next generation enterprise software. Enterprise software is a big market which delivers solutions for building IT infrastructures to support organisations’ business and daily routines. The market is characterized with a high failure rate, small number of players, and low customer satisfaction. We aim to change how enterprise software is built and satisfy customer needs. Our idea is that complex enterprise software solutions can be built from small building blocks, apps, which can be developed by domain experts. It was proven in the mobile app market that small vendors and individuals can be very successful in implementing specialized apps. To bring our idea to life, we develop tools to create apps efficiently, as well as a platform to run the independently-created apps together, constituting a single software system.The core of our platform is our high-performing ACID-compliant in-memory database management system (DBMS) with a built-in application server. The DBMS is being designed to support real world ontologies, which play important role in our solution. The communication between the server and clients is being implemented according to a Model View ViewModel (MVVM) pattern. The client part of our platform is built with Web Components and provides the ability to mix user interfaces (UIs) of independently-developed apps into a single UI representing a software package.Our approach benefits these core audiences in the following ways:- Developers: Simple and fast way to develop apps;- Software providers: Fast time-to-market and expansion of their business;- Customers: Satisfied needs and requirements, fast track from idea to working infrastructure, reduced cost of ownership, and abilit