RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'SmartX is an innovative ICT platform for electricity demand-supply management' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

SmartX - an innovative ICT platform for electricity demand-supply management allows energy suppliers to optimize their operating costs on one hand and reduce electricity bills for their customers on the other. SmartX consists of a central control unit that makes energy supplier able to control energy consumption and generation at the level of single houselhold. For example energy vendor may be interested to limit some non-critical energy-consuming assets at the peak time (like air conditioning when nobody is at home) or maximize home-based PV installation capacity of its customer at the peak time. Thanks to that, the vendor is able to buy less energy in the wholesale market at the peak times. Yielding control over some consuming/producing assets brings value to vendors' final customers - they will be able to pay less for the energy (less consumption in peak times) and/or get better price for the green energy they produce at home and they will not need to pay any attention in order to achieve that. Moreover vendors will probably offer better tariffs to the customers connected to SmartX as the cost of supply-demand risk management for such  group of customers will be much cheaper.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Fibroblasts-microbiome crosstalk in tissue regeneration and fibrosis: unraveling novel therapeutic targets through single nucleus RNA-seq, multi-omics and spatial analysis'.

assistant: **Concept**

Upon injury or disease, most human organs yield fibrotic tissue resulting in permanent scars and the failure of tissue function, compromising the health span and lifespan of affected individuals. Organ fibrosis is influenced by a myriad of factors, including fibroblast heterogeneity, the activated signal transduction pathways and environmental cues. Fibroblasts hold a central role in fibrosis, yet a nuanced understanding of their heterogeneity driving regenerative versus fibrotic healing remains elusive. Recently, it was shown that the microbiome regulates inflammation and extracellular matrix remodeling. However, the microbiota function in tissue regeneration and fibrosis is poorly characterized. Integrating microbiome insights into anti-fibrotic approaches is an uncharted territory. REGENER-OMIX aims at investigating: 1. fibroblast heterogeneity and, specifically, the microbial components-recognizing fibroblasts, and the wound microbiome in the regenerative oral mucosa and pro-fibrotic skin; 2. the fibroblasts-microbiome crosstalk through spatial analysis; 3. the role of the microbiome in the healing outcome toward regeneration or fibrosis.To address these objectives, I will leverage advanced transgenic models, cutting-edge single nucleus RNA-seq, multi-omics and spatial biology techniques through a novel and interdisciplinary approach. The project (36 months) will unravel the interactions between fibroblasts and microbiome, and their functional role in regeneration and fibrosis. This study will offer new avenues to manipulate the healing process and antagonize fibrosis-associated pathologies.I will combine the strengths of a USA-based research group, world-leading expert in wound healing and fibrosis, with the expertise of a world-renowned Europe-based laboratory, wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'High performance telecontrol station with image and sound capabilities'.

assistant: **Concept**

The project aims to develop software to be embedded in the new generation of high-performance computing tele-control stations to be integrated in supervisory control and data acquisition systems.These stations will deal not only with digital and analogue signals produced by conventional process sensors, but also with images and sounds. With their ability to obtain process information through a real-time fusion of conventional control signals, images and sounds, these stations will allow the development of more complete, flexible, reliable and secure control systems capable of solving difficult industrial control problems. To perform all the necessary functions and still satisfy the requirement for real-time operation, the software will have to run on a high-performance computer. For exploitation reasons the system to be developed must be low-cost and highly configurable. A steel-manufacturing process will serve to demonstrate the operation of the system in a real-world pilot application. Such an industrial process has been selected because it has specific control problems that are not well solved by conventional systems, and because of the extreme operating conditions present in steelworks. The successful implementation of the system will allow the end-user to obtain qualitative and quantitative improvements in the operation of the steel-making process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Monolithic Optoelectronic Devices on Silicon'.

assistant: **Objectives**

Nowadays, microelectronics set the pace for the whole knowledge-based economy and society in terms of the ever rising demand for mobile devices and the exponentially growing internet data transfer. However, the widening gap between the increasing number of transistors on a single Si chip and the delivered performance indicates the approaching limits of classical device scaling. Additionally, this miniaturization results in severe energy dissipation in the interconnection of devices. A smart way to overcome this emerging power consumption crisis is to avoid heating by replacing the on-chip and/or chip-to-chip electrical interconnects with optical interconnects. Due to their direct bandgap, III-V compounds are ideal for the integration of photonics with Si-based electronics on the very same chip. This would enable large-scale optoelectronics integration hindered so far by coupling- and overlay issues introduced by state-of-the-art III-V bonding on Silicon. MODES will develop and investigate a novel approach for self-aligned monolithic integration of active and passive III-V optoelectronic devices on a Silicon platform. It focuses on the optimization of GaAs- and InP-based III-V growth within customized oxide templates. Moreover, this research aims at designing and fabricating doped, defect-free III-V heterostructures for electrically-driven optoelectronic devices integrated on Si. Owing to his experience in epitaxy as well as fabrication and characterization of group IV photonics, i.e. laser devices, the fellow complements ideally the competences of the group in III-V epitaxy and fabrication as well as knowledge of design and characterization of optoelectronic devices. Three objectives will be pursued: 1) Growth and integration of III-V material with Si-on-insulator waveg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Demonstrate Ecosystem Services Enabling Innovation in the Water Sector' (DESSIN) targeting Seventh Framework.

assistant: **Abstract**

The main objectives of DESSIN are- To demonstrate and promote innovative solutions to water-related challenges with a focus on: (i) water quality issues related to the implementation of the Water Framework Directive (WFD) and (ii) water scarcity.- To demonstrate a methodology for the valuation of ecosystem services (ESS) as catalyser for innovation in water management.DESSIN will launch demonstration projects of innovative solutions for the two challenges mentioned above, with special focus on urban areas. Solutions will integrate technological, monitoring, modeling and management approaches for a more resource-efficient and competitive water sector in Europe. As a second key feature, an Evaluation Framework to account for changes in the value of ecosystem services (ESS) of water bodies that result from implementation of the solutions will be developed and applied. By adopting this twofold approach, we will be able to demonstrate how innovative solutions integrated in the water cycle can increase the value of the services provided by freshwater ecosystems, thus generating additional incentives and arguments for their market uptake and practical implementation. This will support innovation and competitiveness in water management by enabling a more informed selection of the most promising solutions, as regards their impact on the water body and their economic implications. The whole project is centered around the following suite of carefully selected sites across Europe, representative of global major water challenges, where we bring together public and private water management organisations and end-users, technology providers (SMEs), supporting RTD experts and relevant public authorities to demonstrate this approach: Emscher (Germany), Hoffselva (Oslo area, Norway), West
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of New PET tracers for in vivo 5-HT2A and 5-HT7 Brain Imaging' (2007-2013).

assistant: **Innovation**

Disturbances in the serotonin (5-HT) transmitter system are seen in many neuropsychiatric disorders and brain disorders cause approximately one-third of the burden of illness in Europe. The aim of our proposal is to develop tools for in vivo imaging of the human brain with particular focus on the 5-HT7 and the 5-HT2A receptor. Both the 5-HT7 and 5-HT2A receptors are recognised as being involved in the pathophysiology of brain disorders and are also important drug targets.Today, no suitable PET radiotracer exists for 5-HT7 receptor brain imaging, but access to such a radiotracer would enable new groundbreaking discoveries in human brain disorders. It would also allow the pharmaceutical industry to assess their compounds’ blood-brain barrier penetration and receptor occupancy in humans prior to clinical trials and thereby importantly guide the choice of drug dose. With the development of our promising 5-HT2A receptor agonist [11C]Cimbi-36 we will explore the exciting prospects of its ability to image the brain’s own 5-HT release under pharmacological and functional challenges. Our last goal is to develop a general method for 18F-labelling of aromatic rings that could expand the possibilities for 18-F radiolabelling with this longer-lived radioisotope and thereby enable dissemination throughout Europe to complete, e.g., multi-center studies with productions in a few European centres.On a world-wide scale, there is a severe shortage of skilled and experienced PET radiochemists. The steeply increasing numbers of PET centres throughout Europe has generated an urgent and unmet need for the type of cross-disciplinary skills that will be provided through the planned training programme.The project has been initiated and the concepts tested over the last 9 months. This has enabled
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ordered Nanoporous Carbon Architectures from Biobased Building Blocks' (BioNanoCarb).

assistant: **Concept**

Ordered nanoporous carbons are gaining appreciable interest in several green technology applications (efficient charge storage, metal-free carbocatalysis). Nevertheless, at present they can only be fabricated using fossil fuel-based building blocks, through energy-intensive processes with large ecological footprint, and with potential environmental pollution. The overall aim of this project is to provide more sustainable alternatives to these fossil fuel-derived materials by fabricating ordered nanoporous carbons from biobased constituents. Our project will focus on studying biobased polymer-biobased surfactant supramolecular assemblies (objective 1) to develop a soft-templating system using only biobased building blocks (objective 2), for obtaining various ordered nanoporous carbons (objective 3) and apply them in charge storage systems (supercapacitors, objective 4), and for metal-free carbocatalysis (advanced oxidation process, objective 5). Our goal is to have control on the nanoarchitecture and understand structure-performance relationships in applications in order to obtain cutting-edge, high-performance materials for advanced devices. Our novel bottom-up approach will give the first biobased soft-templating method to make ordered nanoporous carbons, and is expected to open up new research directions for sustainable material solutions. This project will provide materials and processes with reduced ecological footprint over existing products and technologies, contributing to a sustainable economic growth and to the realisation of a resilient society.


**Keywords:** green chemistry, materials science, biomass, nanoporous carbon, supercapacitor, carbocatalysis, water treatment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dosimetry for Radiation Sterilization of Medical Devices' (1994-1998).

assistant: **Innovation**

The principal objective of the project is to improve the accuracy with which radiation dose is delivered in industrial radiation sterilization plants. This will be done through a series of intercomparisons between industrial irradiation facilities and calibration laboratories, and through the development of written protocols describing standard methods for the calibration of industrial dosimetry systems. These protocols will, in turn, assist in the uniform regulation of the sterile medical device industry throughout the European Union, and promote free trade in radiation sterilized medical devices. A brief outline of the project is given below: An initial intercomparison will be carried out open to all industrial facilities within the EU that sterilize medical devices. The intercomparison will be carried out using mailed chemical dosimeters supplied by recognised calibration laboratories within the EU. For electron plants, the energy will be restricted to energies between 1 and 10 MeV. For both cobalt-60 and electron plants, the dose range will be between 1 and 50 kGy. Plants will be asked to irradiate the intercomparison dosimeters under normal plant operating conditions. A first workshop open to all participants will be convened to discuss the intercomparison results and to draft guidelines for establishing accurate, traceable measurements in industrial plants. Separate guidelines will be developed for gamma and electron dosimetry. A second intercomparison will be carried out in which participants will be asked to follow the procedures established in the guidelines. A second workshop will be held open to all participants in the second intercomparison. Practical experience gained during the second intercomparison will be used to finalise the draft guidelines. Publicati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The application of polymer electronics towards ambient intelligence' (POLYAPPLY).

assistant: **Concept**

Things that think and the communication of people with such things in his environment critically depend on contactless communication technologies. RF communication devices and protocols have been developed in the past and exist today, yet in their present form they cannot and will never be used on a large scale to allow communication with everyday objects.The fundamental reason for this is the cost of the silicon technology employed to realize it. Even in its most optimistic projection, this cost remains at least one order of magnitude higher than the cost of a technology that has been proven to be truly ubiquitously applicable, such as a barcode. Therefore, a new generation of devices is required to enable ambient intelligence at the right cost point in order to be truly applicable everywhere and anywhere.The objective of PolyApply is to lay the foundations of a scalable and ubiquitously applicable communication technology. The boundary condition is the cost of the microsystem, combining basic RF communication with sensor functions. The key to achieving a fundamentally different cost point than what will be reachable in the future with the evolution of the existing technologies (e.g. CMOS), is to resolutely move to adisruptive new manufacturing technology: going from batch processing to in-line manufacturing technology.The semiconductor system envisaged to this end is based on polymers. The scalable aspect refers to the fact that PolyApply does not plan to propose a solution for a certain generation of RF communication devices useful at one point in time, but rather intends to develop generic technologies with a meaningful impact in the mid- and long term. In other words, the developed technologies will lead to an extendable family of products, ranging from simple" RF
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Institutional interaction - how to prevent conflicts and enhance synergies between international and eu environmental institutions (INTERACTION)'.

assistant: **Innovation**

The project examines the interaction between international and EU environmental institutions. Such interaction affects the effectiveness of international and EU environmental policy-making. The core of the project is made up of twelve case studies analysing inter-institutional conflicts and synergies generated or suffered by a) five important international environmental regimes (climate change, biodiversity, protection of the North Atlantic, High Seas fisheries management, CITES) and GATT/WTO, and b) six important European environmental directives (habitats, water framework, IPPC, air quality framework, environmental liability and deliberate-release directives). Of particular concern will be the vertical interaction between international and EU instruments. Case studies will rely on a common theoretical concept. Their comparative evaluation will produce generalised knowledge on institutional interaction and specific policy recommendations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The histone H3.3 variant in brain cancer pathogenesis' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Epigenetic reprogramming is a hallmark of brain cancer. Remarkably, driver mutations of the histone H3.3 variant and its loading machinery have been recently found in paediatric glioblastoma multiforme (GBM), a devastating neoplasm originating from transformed neural precursors. Thus, the very basic building blocks of chromatin can be mutated in cancer.The present challenge is to define at which level altered H3.3 loading influences GBM pathogenesis and provide clues into the underlying mechanisms. Based on work from our group and others, we hypothesise that alterations of H3.3 function/deposition would lead to epigenetic changes, deregulated transcription at bivalent loci and other genomic regions, and alterations of telomere maintenance mechanisms, in turn contributing to tumourigenesis.The main objectives of this proposal are to:1. Examine the impact of H3.3 mutations on brain cancer pathogenesis, by determining the effect of mutant H3.3 expression on neural precursor cell transformation (A), and tumour maintenance (B).2. Define the molecular changes caused by incorporation of H3.3 mutants into the genome and their involvement in tumourigenesis, by A. determining the genome-wide distribution of WT and mutant H3.3 proteins, B. identifying mutant H3.3-driven transcriptional and epigenetic changes, C. defining effects on telomere maintenance mechanisms, and D. connecting mutant H3.3-driven molecular changes to the biological phenotypes.The discovery of mutations in histones and their loading machinery represents a paradigm change in the field of cancer epigenetics. We anticipate this study to provide key insights into the role of these alterations in chromatin regulation and cancer pathogenesis. More broadly, this work will increase our understanding of the fundamental