RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Policy Incentives for the Creation of Knowledge: Methods and Evidence' (PICK-ME) targeting Seventh Framework.

assistant: **Abstract**

The ongoing global economic crisis is seriously challenging advanced capitalistic economies. In the last year the GDP has fallen at dramatic rates, creating the conditions for the upsurge of unemployment, above all in areas characterized by specialization in mature industries. According to recent growth models and empirical evidence, innovation and knowledge creation represent the main factors able to improve the competitiveness and the long run perspectives of growth of countries. Yet, innovation and technology policies have mainly been designed by relying on a supply side perspective so as to affect the creation of knowledge by providing funds to carry out R&D activities and by enhancing education and training for researchers. However, a debate has recently emerged, about the need for grafting innovation and technology policies in a demand-oriented framework. The aim of this project is to provide an original contribution to the ongoing debate, advancing the understanding of the mechanisms through which demand-based innovation policies may stimulate effective knowledge creation process, and eventually trigger competitiveness and productivity growth. To this purpose, the research activity will consist of both theoretical models and empirical analyses, the results of which should be able to inform the policy design process. We shall distinguish between public and private demand for both final and intermediate goods and services and will analyze their effects on the generation, diffusion and exploitation of technological knowledge by articulating the research activity on different dimensions (regional, sectoral and institutional). The research activity will be conducted by pursuing a great deal of multidisciplinarity and combining a number of diverse methodologies. The re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Functionalised Activated Sapphire Thin-disk (FAST)', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Optical materials are indispensable for modern society reliant upon technology to create and share information, fabricate advanced materials, and study the intricacies of our physical universe. Our Pathfinder science-to-technology breakthrough targets a paradigm shift for fabricating a novel optically active crystal – rare-earth (RE) doped sapphire. Sapphire is an exemplary material, second only to diamond in the Mohs hardness scale and 3rd in the list of the hardest natural minerals – importantly, 1st in this list that can incorporate RE ions into its lattice. In adopting a radically different non-thermal-equilibrium crystal-growth method, namely Rapid Pulsed Laser Deposition (RPLD) we capitalise on an order-of-magnitude higher deposition frequency than regular PLD and, in addition, exploit the ability to incorporate substantially more RE impurity than conventional crystal-growth techniques can achieve. With practically relevant doping concentrations RE-doped sapphire (REDS) promises a step change in critical properties for laser gain elements, especially Yb:sapphire thin disks. A greater than tenfold improvement in laser power is anticipated in like-for-like replacement of a state-of-the-art Yb:YAG thin disk with a Yb:sapphire one. However, we propose additional science-to-technology breakthroughs that will potentially offer a further order-of-magnitude performance enhancement. The first addresses Amplified Spontaneous Emission (ASE), a limit to power scaling thin-disk lasers, whereby we will nanoengineer key surfaces of the active elements to functionalise them and control their optical properties. Functionalising the activated sapphire promises ASE mitigation and aperture scaling opportunities for a new generation of thin-disk gain elements in extreme-power photon e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dispower - distributed generation with high penetration of renewable energy sources.' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Objectives and Problems to be solved:Due to the ongoing process of deregulation of the European energy market, the unbundled energy sector is now in transition to more competition in electricity generation, distribution and trading. With free access to the electrical distribution grids and suitable energy wheeling conditions, new players will arrive in the competitive market, further supporting the already existing trend towards more distributed generation (DG) of power, which has mainly been induced by the increasing integration of Renewable Energy Sources (RES). This development will lead to many technological as well as regulatory challenges and will require a further development of the legal framework conditions. The project intends to support the above-mentioned process of transition of nowadays energy supply system towards a more decentralised and market oriented supply structure. Description of the work :The objectives comprise a wide range of energy and information technology related topics. Starting with the elaboration of strategies and concepts for grid stability and system control in distributed generation networks, the basis for the application of tomorrow's power supply technologies will be built. The preparation of safety and quality standards in DG networks and investigations on quality improvements and requirements of distributed generators including inverter coupled power stations will be analysed as well as socio-economic issues like assessment of impacts to consumers by information and communication technologies, energy trading and load management. The development of planning, design and training tools to ensure reliable and cost effective integration of DG components into regional and local grid structures will furthermore support the case studies a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Eliciting Mucosal Immunity to Tuberculosis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Tuberculosis (TB) is a global health problem, killing 1.5 million of people every year. The only currently available vaccine, Mycobacterium bovis BCG, is effective against severe childhood forms, but it demonstrates a variable efficacy against the pulmonary form of TB in adults. Many of these adult TB cases result from the reactivation of an initially controlled, latent Mycobacterium tuberculosis (MTB) infection.  Effective prophylactic vaccination remains the key long-term strategy for combating TB. Continued belief in reaching this goal requires unrelenting innovation in the formulation and delivery of candidate vaccines.  It is also based on the assumption, that the failure of recent human vaccine trials could have been due to a sub-optimal vaccine design and delivery, and therefore should not erode the key principle that a TB vaccine is an attainable target. This proposal focuses on mucosal vaccination, which has been considered in the past, but not implemented efficiently. The innovation of the proposal is focused on several important aspects of vaccine development and testing, including the use of novel technologies for vaccine delivery, novel ways of specific targeting of mucosal immune cells and tissues, the use of polypeptides incorporating early and latent MTB antigens and putative CD8+ T cell epitopes, and application of novel tools for identifying early predictors and correlates of vaccine-induced protection. The overall objective is to design a vaccine that will induce a broad-ranging immune response to MTB both systemically and in the mucosa of the lungs, and provide the currently missing links in protective immunity to this pathogen.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Boosting Innovation in Organic GREENhouses via stronger NETworks' under Horizon Europe.

assistant: **Concept**

The EU is a major player in greenhouse production, with about 175.000 ha dedicated to this purpose. In 2021, a total of 13.62 k tonnes of vegetables were cultivated in greenhouses in the EU. However, greenhouse production remains a niche sector for organic production (3% of the total organic area in the EU). Furthermore, Organic greenhouse production is highly knowledge-intensive and represents unique challenges such as the maintenance of soil health, biodiversity and pest control with a limited set of inputs. In addition, structures can be costly, require skilled workforce and present high regional variability in their production strategies. Research findings are not sufficiently integrated into agricultural practices tailored to the diverse needs and conditions faced by greenhouse producers in different areas. Moreover, there are insufficient nodes to establish meaningful connections among farmers. BIOGREENET aims to collect, evaluate, adapt, share and foster the uptake of consolidated practices and promote knowledge exchange by increasing collaboration among communities. Agriculture Knowledge and Innovation Systems (AKIS) will be reinforced, and new local, regional and cross-border platforms will emerge and encourage the sharing of knowledge, innovation and digitalisation among producers, advisors, researchers and other relevant stakeholders across and beyond the EU. A transdisciplinary team of organisations has grouped in BIOGREENET to spark innovation and induce a collaborative environment in the community through a bottom-up approach and digital initiatives that will establish the base of synergies with EIP-AGRI projects and strengthen AKIS. Over a four-year project, the engagement of >3,000 producers and specialised advisors through up-to-date knowledge digital p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Multi-omics molecular treatment targets for Prostate Cancer'.

assistant: **Innovation**

The PCaProTreat Project targets on improving the Prostate Cancer (PCa) management and focuses on the identification of novel therapeutic targets for patients with an advanced disease stage. It has been demonstrated that the current medical practice has led to frequent over-treatment of patients exhibiting slow growing PCa (unlikely to progress in the absence of treatment), while for metastatic castration resistant  patients that immediate treatment is required, no effective strategies are available. Therefore, new therapeutic options are required for advanced PCa. To address this clinical demand, PCaProTreat is focused on the comprehensive characterisation of the molecular background of PCa progression, based on which molecularly-driven therapeutic targets can be defined. Towards that end, PCaProTreat includes: a) multi-layer analysis (different types of specimens: tissue, urine, seminal plasma) and multi-omics profiling (proteomics, peptidomics, transcriptomics), supplemented with literature-mined data, b) establishment of the PCa knowledge database, c) data integration into Systems Biology workflow to identify key-regulatory elements responsible for disease progression (best suited drug targets) and d) validation of the selected targets using immunohistochemistry. This multi-dimensional approach represents a substantial advancement over the standards currently applied in drug discovery process, allowing to overcome the challenges associated with tumour heterogeneity and thus reveal optimal drug targets. In parallel to the research activities, a multi-disciplinary and multi-sectorial training program will be implemented to increase the competitiveness of the ER within the research community, to become a recognised researcher. Activities will be carried out in the indus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Role of sulfate-reducing bacteria within microbial mat system in hydrocarbon biodegradation' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Microbial mats are recently known to play a significant role in the bioremediation of oil polluted coastal areas. Such systems are thus likely to be of significance in the effective management of sensitive coastal ecosystems chronically subjected to oil spillage. The aim of this project is to study the functional role of microbial mats in the biodegradation of hydrocarbons. The studies will be conducted on several outdoor experiment mesocosms in which a controlled microbial mat will be exposed to oil pollution selected model hydrocarbon compounds. Biological changes following introduction of hydrocarbons will be studied in terms of microbial diversity coupled with functional diversity of the sulfate-reducing bacterial community, using molecular tools and activity measurements.Spatial and temporal shifts of sulfate-reducing bacterial community will be analyzed along vertical environmental gradients with a high resolution level of about 100 micrometers and at different times after oil exposure. After a period of adaptation following exposure to hydrocarbons, characterization of predominant sulfate-reducing bacteria will allow a better understanding of their physiology in oil degradation. Biological changes will be also studied after a second oil exposure to assess the involvement of well adapted" sulfate- reducing bacteria in oil biodegradation. This study is expected to contribute significantly to our knowledge of the role of microbial mats in bioremediation of oil polluted coastal zones."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Functional DNA-based nanomaterials using metal-mediated self-assembly processes' in the context of a Seventh Framework call.

assistant: **Objectives**

This research project will focus on the development of conducting molecular architectures using self-assembly processes between specific DNA sequences and metal ions-derivatives. The concept is to use the interaction of specific metal ions towards precise DNA nucleobases. Novel synthetic metal complexes will be prepared carrying specific functional units capable of directing the formation of conducting polymers. These metal complexes will be organized at the nanoscale by interaction with particular DNA base-sequences through self-assembly processes. The project will also involve the preparation of complex DNA-based nanomaterial structures through a novel route which extends upon the well-established DNA origami concept using the unique properties of metal ions and their specificity to form metal-mediated DNA duplexes. The self-assembly properties of DNA and specific metal-ions will be explored for the construction of complex nanoscale architectures. Importantly, the original methodology proposed will be also employed for the incorporation of further functionality into DNA-based nanomaterials, since the properties of the metal-complexes can be tailored with different functional groups.Established synthetic methodologies will used for the synthesis of the metal-precursor compounds and these will be characterised using standard techniques to set up structural details, e.g. NMR, elemental analysis, ionized electrospray mass spectroscopy LC(IES-MS), spectroscopic (FTIR, UV-vis). The formation of conducting polymer nanomaterial will involve chemical oxidation or metal-coordination of the organized units along the DNA molecules. The resulting materials will be characterised using a range of spectroscopy techniques (FTIR, CD, UV-vis) as well as state-of-the-art scanning probe m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanisms of Kaposi's sarcoma herpesvirus replication and maintenance during latency', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Oncogenic viruses are the third most common cause of cancer in humans. Kaposi’s sarcoma herpesvirus (KSHV) is an oncogenic virus that establishes life-long latent infection and can drive tumor development in immunocompromised individuals. To date no definitive treatment against KSHV has been developed and KSHV-derived cancers are uncurable. Despite the advances in understanding KSHV biology, many key aspects are still obscure, and detailed mechanistic studies are needed for the development of rational targeted therapies.  During latency, KSHV exploits the host cell’s replication and segregation machineries to faithfully copy and transmit its genome during cell division. Which cellular proteins contribute to these processes and what mechanisms enable the virus to preserve its genome over time remain poorly dissected. I will remodel the Xenopus laevis egg extract in vitro system, which has been successfully applied to study eukaryotic replication and chromosome segregation, to incorporate the key components of KSHV maintenance and generate a unique tool to dissect the mechanisms of KSHV latency in a test tube. With this innovative system in hand and strong of a previously developed powerful mass-spectrometry workflow for protein identification, my group will overcome the limitations of the current methodologies to answer two main questions. (1) What is the extent of the host’s proteome that contributes to KSHV maintenance? (2) What are the molecular mechanisms that drive faithful segregation of the viral genome?  Corroborated by parallel experiments in KSHV infected cells, these ground-breaking findings will answer long-standing questions on the latency of KSHV, setting a solid base for the development of targeted therapies. Furthermore, the newly developed latency system
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Advanced metal forming technique for production of three dimensional tubular steel products' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

In line with the programme areas identified, 2.1.1S manufacturing cost reduction for equal or increased functionality of existing materials and 2 l.lM, new more accurate and energy efficient near net shape forming reducing costs, energy and waste in mass production, the overall aim of this project is to develop a one shot near-net, forming, cutting and de-burring process for three dimensional tubular steel products. With ongoing trends particularly in the automotive sectors of value and simultaneous engineering, an opportunity exists to develop a unique manufacturing method, which is beneficial not only in cost and productivity terms, but also as a means of allowing quality to be designed into both products and services giving increased reliability, shorter lead times and faster time to market. This process involves clamping a section of tubular steel between a high precision split die incorporating the form of the component to be generated, the die being held together by high pressure. This pressure is required to contain the forming process when an expandable, eg. a rubber type of material, insert is forced under pressure at the centre of the component to be formed, and expands out forcing the material into the form of the die, forming, cutting off and deburring the component. This process is subject to UK Patent Application Number 9608388.6. This project is centred around the following key areas: - The development of a technique for forming, cutting and deburring tubular steel components in a one shot near net fabrication process. - To demonstrate the ability of consistently producing high quality precision components which are identical in size and provide a ten fold increase in dimensional accuracy, eg + 0.1mm to + 0.01mm. - To demonstrate the manufacture of near n