RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'D&G GREEN PROJECT' (1994-1998).

assistant: **Innovation**

The project is aimed at direct energy saving by means of : - the reduction energy consumption due to the modification and, for some products the suppression of some steps in the traditional process (in particular the finishing phases responsible considerable thermal energy consumption)- the elimination of waste water treatment due to new needling technology which avoids the use of water + resin mix.- the elimination of emission treatmentConsiderable indirect energy savings are related to :- the substitution of gluing resins (requireing high quantities of energy for their production)- the use of recycled fibers in substitution of new textile fibers (also requiring high quantities of energy for their production)- the recovery of the energy content of the recycled fibers.As a consequence the specific added energy per unit of product in the examined factory and the specific final energy content of the product will be much lower if compared to the traditional process.The designed production plant consists of innovative equipment and some existing technologies and machines (which will be completely modified and rearranged) to obtain a completely new way of produce non-woven textiles. The innovative aspect of the project resides in the development and in the industrial implementation of a new technique to bond textile fibers through : - a random disposition of the fibers coming out from the carding machine- the use of a new needling/punching technology- the use of small quantities of thermo-retracting fibers associated with a successive thermal treatment.The combination of the above methods will allow one to obtain the final product (semimanufactured sheet or carpet) with the desired mechanical characteristics without using gluing resins.a) the production process starts with a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CETOCOEN Excellence' (2014-2020).

assistant: **Innovation**

The goal of the CETOCOEN Excellence project of the Teamig Phase II is to establish the European Centre of Excellence in Environmental Health Sciences. In order to achieve that, Masaryk University in Brno, Czech Republic, teams up with the leading European research institutions including University College London, Swiss Federal Institute of Technology in Zurich, Biobanking and Biomolecular Resources Research Infrastructure, and International Clinical Research Centre at St. Annes Hospital. Building on existing expertise and proven track record of the existing RECETOX Centre at Masaryk university, the Teaming project partners developed a joint vision and a strategy for establishment of the interdisciplinary institute of the next generation. This project utilizes previous investments of the European Structural and Investment Funds to development of excellent research infrastructures and introduces strategic partnerships, advanced research management and research support functions, and new financial schemes needed to become one of the leading European research institutes.  This allows the Centre to open the innovative research avenues  towards improved understanding of the role of environmental factors in human health and aging, and innovative approaches to environmental and health protection in Europe.


**Keywords:** Environmental health science, risk assessment, trace analysis, emerging pollutants, toxic mixtures, toxicology, adverse outcome pathways, environmental epidemiology, protein engineering, sensors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Reconstruction of the post ’Little Ice Age’ geomorphological processes in glacial environments - sedimentological and morphological record of glacial landsystems’ reactions to environmental changes' (GlaciRecon).

assistant: **Innovation**

Sediments and landforms on recently deglaciated terrains are valuable archives of geomorphological processes. Thus, they can be used for reconstructions of the past and present behaviours of glaciers and ice sheets, which are very important indicators of environmental change.The GlaciRecon project focuses on deciphering of geomorphological process in marginal zones of selected modern glaciers, based on morphological and sedimentological evidences. The main scientific objectives of the project are: (1) Recognition and analysis of patterns of depositional and reworking processes of ice-marginal sediments and landforms; (2) Determination which factors have had the most significant impact on the transformation of glacial sediments and landforms since the end of the Little Ice Age (LIA); (3) Reconstruction of the evolution and assessment of preservation potential of modern ice-marginal sediments and landforms.Implementation of the project will help to identify the evolution of the glacial marginal zones at varied temporal and spatial scales. Analysis of different factors and their impacts on glacial landsystems’ transformations provide interpretations concerning the rate and style of glacial retreat linked with wider climatic implications. The realization of the GlaciRecon project improve the quality of local and regional stratigraphy, paleogeography and paleoclimate reconstructions concerning modern and the last glaciation in Europe and the rest of the world. The results of these reconstructions will contribute to the assessment of the impact of further climate changes on glacier/ice-sheet behaviour and global sea-level changes, which are important from a socio-economic point of view as they are used in quantification of resources threatened by sea-level rises.GlaciRecon is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Characterizing Regulatory Principles in Platelet Surface Receptors  Via X-ray Crystallography and Small-molecule Design'.

assistant: **Objectives**

Signaling via platelet surface receptors is essential for maintaining hemostasis and thrombosis, and plays key roles in pathophysiological processes related to development, immune responses and cancer. Despite their vital roles, important aspects of their regulation mechanisms remain unknown due to inherent flexibility and multilayered activation. I propose to embark upon a new approach to investigate the dynamical processes by which platelet receptors are regulated using a combination of x-ray crystallography, electron microscopy, biochemistry, bioinformatics and small-molecule design. My goal is to decipher the atomic mechanistic details of the relationship between ligand-binding, dynamics, activation and transduction of signals in platelet receptors, which would facilitate the development of accurate interventions with their cellular processes, namely drugs that will target a range of cardiovascular conditions. My working hypothesis is that small molecules that act as allosteric regulators can uncover new principles in the regulation mechanisms of these receptors, and can intervene in protein function and nucleate drug discovery efforts. Accordingly, I aim to identify and characterize small molecules that target allosteric sites in these signaling receptors, which are expressed on cell surfaces and bind ligands in the extracellular matrix, making them particularly accessible to exogenous modulation in-vivo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Comparative Genomics and Environmental Diversity of Coral Associated Apicomplexa-Related Lineages'.

assistant: **Innovation**

Coral reefs are home to the greatest density of species in shallow marine waters, including unusually diverse microbial communities. However, almost everything we know about reef microbial communities is confined to prokaryotes and viruses: next to nothing is known about the microbial eukaryotes, with the exception of the symbiont dinoflagellate Symbiodinium. Coral reefs are like most other marine environments, where protists are consistently overlooked. Chromera and Vitrella are two reef-associated algae assumed to have a symbiotic relationship similar to that of Symbiodinium. As photosynthetic relatives of apicomplexan parasites, they held answers to long-debated questions about plastid evolution, but equally important questions about their functional relationship to corals and the reef community have hardly been asked. It has been observed that bacterial sequence surveys are heavily ‘contaminated’ with eukaryotic plastid sequences. The apicomplexanrelated lineages (ARLs) are the richest source of still-unidentified plastid diversity, and virtually all of this diversity is restricted to coral reefs. We know they exist, but have no direct information on their biology or role in ecosystems whatsoever. ARL-V is the most common lineage, but we cannot even say whether the organisms are photosynthetic symbionts or intracellular parasites. To address these questions, an ecological approach was needed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Angiogenic growth, specialization, ageing and regeneration of bone vessels' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The skeleton and the sinusoidal vasculature form a functional unit with great relevance in health, regeneration, and disease. Currently, fundamental aspects of sinusoidal vessel growth, specialization, arteriovenous organization and the consequences for tissue perfusion, or the changes occurring during ageing remain unknown. Our preliminary data indicate that key principles of bone vascularization and the role of molecular regulators are highly distinct from other organs. I therefore propose to use powerful combination of mouse genetics, fate mapping, transcriptional profiling, computational biology, confocal and two-photon microscopy, micro-CT and PET imaging, biochemistry and cell biology to characterize the growth, differentiation, dynamics, and ageing of the bone vasculature. In addition to established angiogenic pathways, the role of highly promising novel candidate regulators will be investigated in endothelial cells and perivascular osteoprogenitors with sophisticated inducible and cell type-specific genetic methods in the mouse. Complementing these powerful in vivo approaches, 3D co-cultures generated by cell printing technologies will provide insight into the communication between different cell types. The dynamics of sinusoidal vessel growth and regeneration will be monitored by two-photon imaging in the skull. Finally, I will explore the architectural, cellular and molecular changes and the role of capillary endothelial subpopulations in the sinusoidal vasculature of ageing and osteoporotic mice.Technological advancements, such as new transgenic strains, mutant models or cell printing approaches, are important aspects of this proposal. AngioBone will provide a first conceptual framework for normal and deregulated function of the bone sinusoidal vasculature. I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of novel antiviral drugs against Influenza' (FLUCURE) under Seventh Framework.

assistant: **Objectives**

Influenza viruses cause a highly contagious respiratory disease in both humans and animals. Typically, influenza spreads worldwide in seasonal epidemics resulting in an estimated 3 to 5 million cases of severe illness and 250,000 to 500,000 deaths annually. In addition to these seasonal epidemics there have been several pandemics since the early 1900’s, where highly virulent strains emerged, the most devastating being the ‘Spanish Flu’ of 1918, which caused 20-40 million deaths globally. Vaccination is currently the primary means of controlling the spread of influenza virus infections but due to the virus’s notorious ability to mutate, new vaccines must be developed each year. There are a few antiviral drugs that are currently on the market; however, their therapeutic potential is restricted through rapid appearance of drug-resistant viruses during treatment. Thus, the need for novel effective drugs against influenza is evident. The FLUCURE project aims at developing innovative, first-in-class therapeutics against influenza by targeting the viral ribonucleoprotein complex, which is replication core of the virion and a major contributor to viral virulence. The high level of conservation combined with slow mutation rates of the ribonucleoprotein complex should result in therapeutics with broad viral strain specificity associated with a reduced risk for developing resistance. FLUCURE builds further on two successful EU-FP7 drug discovery projects, FLUINHIBIT and FluDrugStrategy, both targeting specific but different protein-protein interactions of the viral ribonucleoprotein complex with small molecule inhibitors. A consortium of 10 partners with the required complementary skills will progress the lead candidates from these two projects synergistically through lead optimiz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A universally applicable system for direct readout of eukaryotic cell transgenesis with a novel integration-coupled gene expression switch'.

assistant: **Objectives**

Stable integration of exogenous transgenes in the genome of transfected eukaryotic host cells is essential in many biological, biotechnological and biomedical applications. Naked DNA vectors are increasingly applied for this purpose as an alternative to viral particles due to their low cost, easy production and simplicity of use. However, transgenesis with these vectors remains fundamentally hindered by the impossibility to distinguish integrated transgenes from those remaining in episomal form, which causes week-long delays to select stable transfected cells with risks of toxicity or epigenetic drift. We have introduced an efficient strategy to solves these issues, based on a novel genetic switch that conditions DNA transgene expression to incorporation into the host genome. This integration-coupled On (iOn) switch enables direct and accurate identification of integration events following transfection, opening the way to rapid drug-free stable cell transgenesis. Here, we propose to develop universally applicable vectors based on this system enabling simplified one-shot stable transfection of eukaryotic cells with one or multiple transgenes, among others. Our project will set conditions for diffusing a breakthrough technology with strong potential to accelerate genetic engineering in cultured systems and model organisms.


**Keywords:** transgene, stable transgenesis, cell line establishment, genetic engineering, genomic integration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Distributed Research Infrastructure for Hydro-Meteorology to United States of America' in the context of a Seventh Framework call.

assistant: **Objectives**

Hydro-Meteorology Research (HMR) is an area of critical scientific importance and of high societal relevance. It plays a key role in guiding predictions relevant to the safety and prosperity of humans and ecosystems from highly urbanized areas, to coastal zones, and to agricultural landscapes. Of special interest and urgency within HMR is the problem of understanding and predicting the impacts of severe hydro-meteorological events, such as flash-floods and landslides in complex orography areas, on humans and the environment, under the incoming climate change effects.Thus, building on existing but regional projects such as DRIHM (Distributed Research Infrastructure for Hydro-Meteorology, EU) and CESM (Community Earth System Model, US), DRIHM2US project will help in understanding the utilization of e-Infrastructures for advancing scientific collaboration on both sides of the Atlantic towards improving the predictive ability of severe storms and utilization of these predictions for hazard prediction and control under climate change effects.  As such, HMR serves as a key example for the utilization of e-Infrastructures in Advancing Science of Service to Society and can be a lighthouse for broader directions within HMR and for other scientific disciplines.Along these lines DRIHM2US will promote international cooperation between Europe and the USA for the development of a joint/common e-Infrastructure using Hydro-Meteorology Research (HMR) as an example, to ensure persistent availability and effective sharing of data and models across scientific disciplines, institutions, and national boundaries, specifically across the Atlantic.The goal will be achieved by creating a forum of collaboration, based on a sequence of networking actvities with EU and US participants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'OPTICAL FIBER-TIP NANO SENSING (OPERAS)' to be submitted under Horizon Europe.

assistant: **Abstract**

Ultra-compact sensors that can detect single nanoscale objects are presently highly desirable. However, state-of-the-art sensors lack selectivity and the concurrent detection of multiple analytes. Thus, OPERAS seeks to build an enhanced class of highly selective and sensitive fiber-tip sensors based on nanophotonics and plasmonics that can be easily multiplexed. Its distinctiveness stems from the introduction of quantum perturbation method (QPM) for nanoparticles' susceptibilities, full vector beam propagation method (FVBPM) for fiber sensor optimization, and gold nanoparticles immobilization protocol on the end facet of an optical fiber to fabricate the sensing probe. These methods are not only reproducible but also allow real-time monitoring of the fabrication process, making batch sensor fabrication feasible. With the combination of optical phenomena at the nanoscale, optical fiber technology, and advanced simulation based on the QPM and FVBPM, OPERAS seeks to create synergistic nanospectroscopic sensors for uses in a variety of fields. The fabricated sensors will be tested for the detection of nanoplastics and heavy metals in water at concentrations as low as nanograms per liter. Other applications including disease diagnosis and environmental monitoring are also foreseen. Although the sensor has good selectivity and hypersensitivity due to the QPM and FVBPM, its implementation through the use of an optical fiber makes the sensor compact, safe to use, and easy to interrogate. This creative and well-organized project will undoubtedly yield numerous important research outputs that will further our understanding of the exposure of people to nano objects, highlight and support European research in this area, help establish an affordable sensing technology, and improve e