RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Preparation and characterization of photo-responsive microcapsules based on azobenzene derivatives, for controlled delivery of active agents under visible light', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Encapsulation process is described as the capture of a compound into a coating material. Besides encapsulation technology is currently the best solution available on the market for the delivery of dedicated components/materials in different applications such as: food ingredients, perfumes, drugs, dyes, acids, pesticides and herbicides, etc. The main strategic objective of PhotoCap is to create an innovative platform for interdisciplinary research with the aim to accelerate the adoption of microcapsules-innovative solutions with significant contribution to European excellence. The research objective of the PhotoCap project focuses on development and testing of new photo-control release microcapsules for innovative breakthrough applications with high impacts on: environmentally-friendly production methods, health protection and increase of citizen daily life standard, with decreasing its cost. The novelty of this project will be preparation of new smart microcapsules based on azobenzen derivatives monomers containing electron-donating groups ortho to the azo moiety. It means that the controlled release of the encapsulated active agent will occur by visible light irradiation from sun illumination. During the PhotoCap I wish to develop and explore encapsulation and triggered release using as a model non-toxic substances such as perfumes under mild, consumer-relevant irradiation conditions. I wish to explore the incorporation of photo-responsive trigger materials into different encapsulation wall chemistry (e.g., polyamide, melamine formaldehyde), and seek to understand the stability and release behavior under different conditions of irradiation. During reintegration phase I wish to apply these new smart microcapsules to real products from EU market, check their stability in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Generating self-antigen diversity in the thymus: from gene expression patterns in single cells to the system level, an integrative approach' in the context of a Seventh Framework call.

assistant: **Objectives**

The thymus plays a central role in the induction of self-tolerance, a hallmark of the immune system. During T cell development a highly diverse T cell receptor repertoire is probed against a matching array of self-antigens. While the generation of the T cell receptor repertoire relies on unique genetic recombination mechanisms, the corresponding molecular principles underlying the generation of TCR ligands - self-peptide/MHC complexes - are less well understood; recent data indicate that novel principles of epigenetic control are employed. This proposal aims at understanding a unique feature of thymic epithelial cells (TECs), namely the expression of a multitude of tissue-restricted antigens (TRAs), a phenomenon termed promiscuous gene expression (pGE) in the context of self-tolerance. The integrative approach of this proposal has 4 main objectives (i) a characterization of the molecular control of different pools of pGE beyond the role of the Autoimmune Regulator (Aire) in relation to the developmental biology of TECs (ii) a comprehensive and comparative analysis of expression patterns of TRAs in single cells of different species in relation to epigenetic signatures and higher chromatin order, (iii) translating these findings to the cellular dynamics and topology of the thymic medullary compartment, e.g. individual mTEC clones in situ (iv) the modelling of these different levels of analysis by a system biology approach, e.g. testing our hypothesis that clusters of TRAs in the genome represent an “operational unit” of pGE. We expect from these studies new basic insights into a fascinating and still arcane aspect of the vertebrate immune system, which will also contribute to our understanding of the etiology and pathophysiology of human autoimmune diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Systematic profiling of molecular changes during prion disease progression' in the context of a Horizon 2020 call.

assistant: **Objectives**

Prion diseases are fatal neurodegenerative diseases and are caused by proteinaceous infectious particles termed prions. The infectious agent of prion diseases has been identified decades ago, but the actual cellular processes that subsequently cause neurons to degenerate remain poorly understood. I propose the systematic analysis of molecular changes in various organs from prion-infected mice. I will profile translation rates and mRNA abundance on a genome-wide scale via ribosome profiling and RNA sequencing, respectively. This will allow me to identify molecular changes during prion disease progression and to decipher the relative contributions of differential transcriptional and translational regulation to them. By relating these changes to prion titers and clinical symptoms I will establish correlations between molecular changes and disease progression. This will identify single genes as well as gene networks that are linked to disease pathology. The analysis of various organs at multiple time points following prion inoculation will enable me to dissect the dynamics of disease progression and the role and interplay of the different organs in pathophysiology. I will further study the causal role of identified candidate genes in prion pathology. To this end, I will investigate the effect of their knock-down and knock-out on prion clearance, replication and toxicity, using a previously established fully automated digital prion infectivity assay. This approach will identify a comprehensive list of genes that are differentially regulated during prion disease progression and that are important for different aspects of prion pathogenesis. This will not only help to better understand the manifestation of prion disease and other neurodegenerative diseases but also provide pot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Designing Safer Urban Spaces'.

assistant: **Objectives**

The DESURBS project makes significant and novel advances with the following developments: 1) An urban space security event database that includes incidents or ‘near misses’ that have (or might have) resulted in injury or loss of life, damage to urban spaces, the auxiliary infrastructures supporting those spaces, or the surrounding natural environment 2) An integrated security and resilience (ISR) design framework that engages local stakeholders for identifying vulnerabilities and improving urban spaces with respect to security threats. 3) Comprehensive and generic supporting tools and methodologies including urban resilient design guidelines and quantitative risk and vulnerability assessment models, tools and technologies to facilitate the qualitative ISR assessment process. 4) A web-based Decision Support System Portal integrating the project’s outputs and including tailored visualization and mapping tools to help end users better understand the vulnerabilities and design possibilities. An objective rating scale for quantifying safety of different urban space designs is developed and used to show that DESURBS solutions result in urban spaces less prone for and less affected by security threats. Primary case studies with end users in Jerusalem in Israel, Nottingham in the UK and Barcelona in Spain inform the development process. The consortium consists of eight partners from five countries, and includes academic and research institutions as well as an SME for exploiting the project’s outputs among end-users and stakeholders. The SME partner is committed to maintaining, updating and hosting the DESURBS Decision Support System Portal and associated databases and tools after the lifetime of the project. An Advisory Board with members from governmental and municipal urban p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cellular basis of spontaneous electrical activity in the developing brain', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content Recent experiments have established the presence of spontaneous oscillations in electrical activity within neuronal networks of adult and developing brain centers. This type of activity has been recorded in different structures of the nervous system, including retina, spinal cord, brainstem, thalamus and cortex. Some findings suggest that this spontaneous activity may have a critical influence upon the correct development of neuronal connections and functional properties of neuronal circuits. The principal objective of this proposal is to investigate the cellular mechanisms underlying the generation of spontaneous electrical activity in the developing brain. The chosen preparation is the isolated brainstem (and slices) of the chick embryo, at different developmental stages. Recent findings have provided clear evidence indicating repetition of neuronal networks, having similar (but not identical) rhythmogenic properties, along the rostrocaudal axis of the developing chick hindbrain. The applicant proposes to use in-vitro recording techniques, combined with Ca2+ imaging techniques and neuroanatomical tracing techniques to identify and characterise the cellular elements involved in the generation of spontaneous oscillatory motor activities. The working hypothesis is that oscillatory motor activity depends on the activity of synaptically connected pacemaker neurons. The proposal outlines experimental strategies (extracellular recordings, Ca2+-imaging and labelling methods) to identify the location of putative pacemaker neurons within the brainstem. Following the location of pacemaker neurons, cross-correlation and spike triggered-averaging techniques will be used to establish the pattern of connectivity between pacemaker cells and other brain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Polar organic pollutant integrative sampler for assessing bioavailability' to be submitted under Sixth Framework.

assistant: **Abstract**

This proposal aims to support the collaboration of world-class researchers to study endocrine disrupting chemicals (EDCs), with the broad aim of supporting the development of dynamic world-class human resources in the European research system. The proposal consists of a scientific project and scientific and complimentary training. The scientific project aims to develop a polar organic pollutant integrative sampler (POPIS) for assessing the bioavailability of polar EDCs in fish. The specific objectives are: -To develop a novel POPIS device suitable for concentrating polar and most potent EDCs -To refine and apply sampling and analytical methods to target EDCs in water and sewage samples.-To perform laboratory experiments to determine the relationship between the levels of EDCs in POPIS and those in water, sediment and fish under controlled conditions.-To conduct site trials to assess the performance of POPIS in simulating bioaccumulation of EDCs in fish.-To develop and validate a multi-compartment model for simulating and predicting POPIS performance. The fellow will receive scientific training to acquire further practical skills in environmental investigations and data analysis; to design, conduct and report on cutting edge research on EDCs; and to strengthen collaboration with European scientists. Complementary training will involve the fellow learning and practising transferable skills. The proposal objectives will be achieved through careful planning and management of the fellowship.The proposed scientific project is timely and appropriate methodology has been established. Novel and state-of-the- art techniques will be used.The supervisors and the fellow have relevant expertises. Regular progress meetings will be held to ensure progress. The fellow will receive train
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Male pregnancy – Unravelling the coevolution of parental investment and immune defence' (MALEPREG).

assistant: **Concept**

The question of how sex roles and parental investment have evolved belongs to the most controversial unresolved issues in evolutionary biology. The costliest form of reproduction regarding parental investment is viviparity. Its independent evolution in most vertebrate groups has required drastic morphological and genomic reorganisations in the sex bearing the young. Yet our knowledge is heavily biased towards mammals, where changes in the immune system and microbial composition are associated with pregnancy and placentation. Which factors have caused the selection and accompanied evolution of viviparity in other vertebrates remains severely understudied. As the evolution of viviparity is a textbook model of convergent evolution, I plan on using a comparative approach to identify selection and fitness benefits leading to the evolution of viviparity. I propose analysing mating system evolution, focusing on the unique evolution of male pregnancy in sex-role reversed syngnathids (pipefishes and seahorses) that show a gradient from external fertilisation to full viviparity and are, thus, ideal to study the evolution of viviparity. Only this genus allows the role of egg production and viviparity to be disentangled, as both traits co-occur in the female in most other species. As immunological tolerance is fundamentally associated with the evolution of pregnancy, I will investigate how male pregnancy has coevolved with adaptive immune system rearrangements and the broodpouch specific microbiota. Comparative genomics, transcriptomics and genetic engineering utilizing CRISPR/Cas9 will elucidate the genetic basis of trait loss and gain required for male pregnancy. In particular, I will assess whether new functions arose via gene duplication and neo-functionalization, via gene co-o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ALL-SCALE PREDICTIVE DESIGN OF HEAT MANAGEMENT MATERIAL STRUCTURES WITH APPLICATIONS IN POWER ELECTRONICS' (ALMA) under Horizon 2020.

assistant: **Objectives**

Heat management is a paramount challenge in many cutting edge technologies, including new GaN electronic technology, turbine thermal coatings, resistive memories, or thermoelectrics. Further progress requires the help of accurate modeling tools that can predict the performance of new complex materials integrated in these increasingly demanding novel devices. However, there is currently no general predictive approach to tackle the complex multiscale modeling of heat flow through such nano and micro-structured systems. The state of the art, our predictive approach “ShengBTE.org”, currently covers the electronic and atomistic scales, going directly from them to predict the macroscopic thermal conductivity of homogeneous bulk materials, but it does not tackle a mesoscopic structure. This project will extend this predictive approach into the mesoscale, enabling it to fully describe thermal transport from the electronic ab initio level, through the atomistic one, all the way into the mesoscopic structure level, within a single model. The project is a 6 partner effort with complementary fields of expertise, 3 academic and 3 from industry. The widened approach will be validated against an extensive range of test case scenarios, including carefully designed experimental measurements taken during the project. The project will deliver a professional multiscale software permitting, for the first time, the prediction of heat flux through complex structured materials of industrial interest. The performance of the modeling tool will be then demonstrated in an industrial setting, to design a new generation of substrates for power electronics based on innovating layered materials. This project is expected to have large impacts in a wide range of industrial applications, particularly in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'DiSsecting fetal genetiC and epigenetic changes After in utero exposure to chemotheRapy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cancer complicates 1 in 1000 pregnancies representing an important health challenge that affects both mother and child. In a series of breakthrough clinical studies, the hosting lab has shown that chemotherapy given during pregnancy is relatively safe for the infants in the short term. However, children born after in utero exposure to chemotherapy are often small for their gestation age, present with lower IQ scores and have higher risk to wear glasses, suggesting possible long-term health effects. Because chemotherapy elicits (epi)genetic alterations to cancer patients, we hypothesize that chemotherapy-mediated long-term health effects could be due to (epi)genetic changes in the offspring of women treated with chemotherapy during pregnancy. Thus, SCAR aims to determine whether in utero exposure to carboplatin may be linked to DNA damage in the offspring. My objectives are to 1) identify the genetic damage at single cell level and 2) determine epigenetic modifications; in umbilical cord blood cells of children in utero exposed to carboplatin. To this end, I will integrate highly innovative sequencing techniques and the access of the hosting team to a unique registry of pregnant cancer patients. As the phenotypic expression of these genetic alterations could take decades to appear, studying the underlying molecular epi(genetic) changes at birth, will provide more immediate evidence than long-term clinical follow-up, and will be instrumental to define safe and solid treatment guidelines for pregnant cancer patients. Through this work, I aim to broaden my scientific expertise (including technical and transferable skills) and my international network for pursuing an academic career in Europe. The MSCA-IF will be instrumental to actualize many objectives outlined in my caree
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'CenAGE, a 'Centromeric' view on AGEing: unveiling centromere instability in ageing' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Ageing is the primary risk factor for chronic diseases. Amongst the ageing hallmarks, genomic instability has emerged as a unifying cause of ageing, since it drives most of the other hallmarks, namely senescence and chronic inflammation. These hallmarks are all typically portrayed by the aged immune system, with compelling evidence pointing to genomic instability in immune cells as a driver of organismal ageing. Intriguingly, while the role of telomeres, mutations, transposons, etc, in age-related genomic instability has been widely investigated, the centromeres have remained largely overlooked. Centromeres are unique specialised regions of repetitive sequences regulated epigenetically that ensure chromosome segregation fidelity. Emergent evidence shows that centromeres are inherently unstable, and recent findings from our labs indicate that centromere instability can lead to genome instability, inflammation, and senescence, including in non-cycling immune cells. In CenAGE, we propose a multi-layer synergistic approach to deliver a ‘centromeric’ view on ageing by: i) characterizing age-associated changes in centromere features in cellular models; ii) identifying the intrinsic (genetic and epigenetic) and extrinsic (viral infection) mechanisms behind centromere-driven senescence hallmarks; iii) establishing the role of centromere dysfunction in physiological decline, focusing on the immune system; and iv) testing how geroprotective interventions that implicate centromeres impact immunosenescence and systemic ageing. There is a timely opportunity to study centromeres in ageing now due to technological advances that enable the sequencing of these ‘blind spots’ of the genome. We expect the CenAGE project, grounded in solid preliminary results and complementary expertise, wi