RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Toxicity of dolutegravir and evaluation of doravirine for alternative 1st line antiretroviral treatment in people living with HIV' (ELDORADO) targeting Horizon Europe.

assistant: **Abstract**

The integrase inhibitors dolutegravir (DTG) is recommended by the World Health Organization (WHO) for 1st line antiretroviral therapy (ART) in people living with HIV (PLHIV) since 2018. Despite its high virologic efficacy, there is growing evidence showing massive weight gain and high incidence of metabolic disorders (obesity, type 2 diabetes) and hypertension under DTG, notably among women from sub-Saharan Africa (SSA) women, along with mental health and quality of life issues. The non-nucleoside reverse transcriptase inhibitor doravirine (DOR) is a potent novel ART, recommended in European and North-American guidelines, but not used so far in Southern countries despite interesting virological, safety and resistance profiles. In this context, the ELDORADO project will generate high-quality data on DTG-based ART toxicity and evaluate DOR as an alternative for 1st-line HIV-1 treatment in order to support national and international policymakers in updating national and international guidelines and practices aimed to improve patient outcomes and reduce disease burden of HIV in sub-Saharan Africa and worldwide. The project includes i) a randomized clinical trial assessing the non-inferiority of DOR-based ART as compared to DTG-based ART in terms of virologic efficacy, and its superiority in terms of key safety endpoints (obesity, diabetes, hypertension) in 610 PLHIV from diverse ethnic backgrounds across in SSA (Cameroon, Côte d’Ivoire, Mozambique), Brazil, Thailand, and France, ii) innovative assessments of organ lesions, iii) assessments of mental health and quality of life, iv) health impact and economics modelling based on the trial results as well as that of other trials (NAMSAL) and cohorts (IeDEA West Africa and Brazil). The project will also prioritize capacity buil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cryogenic storage and refuelling in space' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

To move away from the dependence on hydrazine for space propulsion, greener alternatives must be sought. Cryogenic propellant combinations such as oxygen / methane offer higher specific impulses than storable combinations, but their low saturation temperatures raise additional challenges with respect to preventing their evaporation during long-term storage. While the ability to refuel craft with cryogenic propellants would allow for longer-term manned missions to Mars and the Moon, as well as aid in the improvement of in-space sustainability, preventing the evaporation of the propellants during the transfer process also poses challenges. As of today, neither long-term storage nor refuelling with cryogenic propellants has been demonstrated in-orbit. CRYSALIS will develop and mature the technologies needed for the management of cryogenic propellant for future space transportation and in-orbit servicing activities. This maturation will include performing a small-scale in-orbit demonstration to mature those whose performance can only be characterised in a microgravity environment. This will be a closed-system demonstrator flown on-board the Nyx capsule, which will aim to not only demonstrate the feasibility of such processes but will aim to improve the understanding of the behaviour of such propellants under microgravity, allowing for development of future systems. These technologies will aid in ensuring the independent access of the EU to space, in particular to manned and heavy missions beyond GEO and LEO, by supporting the development of a logistical network of craft, depots, and hubs, required for cis-lunar and future Martian missions.


**Keywords:** cryogenic propellent, in-orbit refuelling, ZBO storage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enable the powder metallurgy process to expand to new markets with more reliable parts and lower manufacturing costs through the inspection of green parts' under Seventh Framework.

assistant: **Concept**

Powder metallurgy is the major manufacturing route for a wide range of industrial parts which are produced by cold pressing powder in a die and sintering the resulting green body in a furnace. The design of a tool, set for a new product, is made with a trial-and-error procedure that generates surplus costs and delays. The optimization of the process is time consuming, due to the lack of fast and systematic system instruments and procedures for the inspection of the material. A major concern in powder metallurgy relies on the unpredictable formation of defects on the parts. While shrinking, internal defects are hard to detect. When the applied pressure is increased, the powder movement gets restricted and shearing can occur unless the magnitude and the direction of the pressure are properly coordinated. Today there is no reliable method able to inspect parts and detect local defects in green state powder metallurgy parts. Test inspection systems have been demonstrated inaccurate and often expensive for being introduced in the industry. The widespread use of powder metallurgy parts instead of parts produced by other competing technologies is often hindered by the impossibility to ensure the absence of defects in powder metallurgy parts. A new inspection tool based on digital radiography technology will be developed for the improved assessment of green parts and enable the powder metallurgy process to expand to new markets with more reliable parts and lower manufacturing costs, which will prove affordable for SME’s. Such tool will reduce the production costs and will decrease the amount of powder used to generate the same number of parts, owing the fact that the powder of the rejected parts can be re-used. With this technology, it will be possible to detect surface and sub
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for '2nd European Conference on Neutron Scattering Budapest, Hungary, September 1-4, 1999' (1998-2002).

assistant: **Innovation**

In modern materials research the complete knowledge of the arrangement and dynamics of the atoms, molecules or their larger assemblies, and of their magnetic properties is required. Due to their unique properties neutrons played essential role in condensed matter research in the past 50 years. Now recent surveys by the European Science Foundation of OECD Megascience Forum have pointed out also the future importance of neutron beam research and urging need for new neutron sources and novel instrumentation. The most important forum of the relevant research community is the series of international conferences on neutron scattering, started in 1988 in Grenoble. The first special "European conference" was organised in 1996 in Switzerland. The European Neutron Scattering Association (ENSA) has decided to hold the second European Conference on Neutron Scattering (ECNS'99) in Budapest, Hungary, September 1-4, 1999. Due to the co-ordination of ENSA a fairly well organised neutron scattering community has been formed in Europe.National associations, European Union funded networks and R&D projects act very stimulating on the user activity and harmonisation of the liaison between neutron centres and the user community. Stable operation of the major existing neutron source facilities in Europe through the past few years, recent start-up of SINQ in Switzerland, current construction of the Garching high-flux reactor and the planned front-rank sources like ESS and AUSTRON open a really promising perspective in this field of research. Considering the extensive development around the neutron sources in America and the Pacific region ECNS'99 will be an important forum not only for the nearly 5000 neutron scientists in Europe but for many colleagues from the other regions as well. The conf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Visualization of Dendritic cell IL-12 production and engagement with antigen-specific T cells during Mycobacterium tuberculosis infection in vivo' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Mycobacterium tuberculosis (Mtb) is a major pathogen that continues to trouble mankind and puzzle immunologists. There is today a growing need for a better understanding of Mtb infection. Dendritic cells (DC) are unique in that they both prime T cells and through IL-12 production direct their differentiation into anti-mycobacterial effector cells. So studying DC and IL-12 during infection has direct implications for improving our fundamental grasp of immunity to this pathogen. DC-T cell contacts occur in the lymph node (LN). However, if and where DC produce IL-12 in vivo remains unknown. In fact, most of the data on DC responses to Mtb comes from in vitro studies that fail to consider the microenvironment of the LN and its constraints on cell-cell and cell-pathogen interactions. The questions herein address the spatiotemporal regulation of mycobacterial antigen acquisition and IL-12 production by DC and whether they give rise to antigen-specific interactions with T cells that dictate effector function generation. These questions remain at large due to methodological impediments. Visualization techniques provide a valuable insight into the complex in situ interplay between DC, Mtb and T cells that governs the host-pathogen standoff. Improvements in imaging now permit the undertaking of these studies in full dynamic view. Visualizing these vital interactions offer new perspectives into understanding and thus manipulating DC for immunotherapy and vaccination benefits.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Augmented PhOtovoltaic ceLLs-based Optical Neural networks for environmental monitoring' in the context of a Horizon Europe call.

assistant: **Objectives**

APOLLON aims to develop a novel solar-cell-based optical neural network (ONN) designed for real-time, energy-efficient environmental monitoring and object recognition. By leveraging solar cells as both sensors and network nodes, the ONN eliminates the need for conventional cameras and external power sources, significantly reducing energy consumption and system complexity. The integration of metasurfaces enhances the system’s optical sensitivity and spectral selectivity, enabling more accurate detection and classification of objects based on light patterns and colours. This innovative approach allows for scalable, self-powered sensor networks capable of continuous operation in remote and hard-to-reach locations. By addressing the challenges of energy consumption, scalability, and real-time data processing, this project aims to deliver a transformative solution that meets the growing demand for sustainable, cost-effective environmental monitoring and establishes a foundation for future commercialization and global deployment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Environmental heterogeneity and AMF genetic diversity' (AMFGENDIV) under Seventh Framework.

assistant: **Objectives**

Arbuscular mycorrhizal fungi (AMF) form mutualistic symbiosis with roots of the majority of terrestrial plants. They are ceonocytic, known to harbour genetically different nuclei. However, the dynamic and maintenance of this genetic diversity are unknown. We have recently found two important processes that are likely to play a role in AMF: a) single spores do not necessarily inherit the same genetic material due to unequal segregation of nuclei during spore formation; b) mixing of nuclei between different individuals can occurs through genetic exchange. Under which circumstances these mechanisms could play a role in the maintenance of genetic diversity has been poorly studied and their occurrence in other AMF populations and species is unknown. Recent investigations suggest that environmental heterogeneity could be a process for the maintenance of genetic diversity and needs further investigations. Additionally, studying how plants respond to the dynamic of AMF genetic structure could allow us to understand how plant and fungi co-evolve. Finally, an important point would be to know whether local adaptation, segregation and genetic exchange could explain the genetic structure of AMF populations in the field. The three objectives of the proposed project will be to 1) test the effect of environmental heterogeneity on AMF genetic structure; 2) determine whether segregation and genetic exchange occur in other AMF populations and species; 3) compare our results with field data. It appears clear that understanding the dynamic and the maintenance of genetic diversity of AMF is essential for understanding the ecological importance of this very common symbiosis, for its application in agriculture and environmental management, and for understanding how organisms evolve and coevolv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mechanism of BVDV fusion' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Increasing evidence suggested that BVDV glycoprotein E2 belongs to the class II viral fusion proteins like flavivirus E and alphavirus E1 protein. In spite of further similarities in entry pathways of BVDV and flavi- and alphaviruses, recently a fundamental difference in the initiation of fusion process was reported.While flavi- and alphavirus fusion is initiated upon environmental acidification, BVD virions are stabilized by disulfide bridges in the viral glycoproteins. Reduction of these disulfide bridges during invasion facilitates the acid dependent fusion. For closely related Hepatitis C Virus also a considerable acid resistance was observed, suggesting a similar fusion mechanism.The mechanism of BVDV membrane fusion will be the main goal of this stud y. This requires substantial structural knowledge of the fusion protein. Thus structural analyses on pestiviral glycoproteins will be performed. Disulfide bridges in the E1-E2 heterodimer, purified from virions, will be mapped. In addition the crystal structure of E2 and/or the E1-E2 heterodimer, which is the predominant glycoprotein in the virion, will be determined from glycoproteins that are expressed in Drosophila cells.A cell-based fusion assay will be established to identify the pestiviral fusion protein by expression of pestiviral glycoproteins at the cell surface. Mutation analysis using reverse genetics will result in the identification of the fusion peptide Understanding of pestiviral fusion mechanism and knowledge of the 3D structure of the pestiviral glycoproteins will have a tremendous impact in understanding the molecular mechanisms of pestivirus entry, and of enveloped viruses in general.In particular, the differences to fusion mechanisms of flavi- and alphavirus promise an exciting new picture of the c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pyramidal neuron polarity decisions during migration and axonal outgrowth in the developing mammalian cerebral cortex' (2007-2013) under Seventh Framework.

assistant: **Objectives**

During embryonic brain development, pyramidal projection neurons are born in the ventricular zone and migrate radially towards the upper part of the cortex to form the cortical plate. These neurons also have to develop dendrites and axons in order to make connections. Several brain diseases and mental illness derive from defects in neuronal migration and positioning or in axon-target interactions for the establishment of synaptic circuitry.  Studies with cultured pyramidal neurons have shown that similar polarity decisions, and many of the same proteins, specify the direction of migration and the orientation of axon outgrowth. However, in vivo, in developing brain, it appears that axons start growing before the completion of neuronal migration, and the axon is always positioned at the opposite side to the migration front. An important open question is to understand how the neuron is able to distinguish spatially and temporally these two opposite polarity signals by using the same polarity proteins in vivo. The results suggest that the situation in a polarized epithelium in vivo is different to that observed in vitro. Indeed, in non-mammalian organism such as the fly, some polarity proteins seem to be dispensable for polarized neuronal migration. We propose to determine the position of the apical pole of a pyramidal neuron during its migration and differentiation in vivo during mouse brain development. We will identify the timing of possible switches in cell polarity relative to the timing of axon emergence, and identify molecules involved in these decisions. Importantly, our studies will be done in vivo and in a living brain slice culture assay.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for ''Electronic’ DOped colloidal Nanocrystal Heterostructures with designed Interfacial composition: towards the development of new nano-device conceptS for lightning and energy Technologies' (EDONHIST).

assistant: **Innovation**

Lighting is responsible for over 20% of global electricity usage, most of which is wasted due to the low efficiency of current technologies. Unlike these, Solid-State Lighting (SSL) has the potential to be a 100% efficient technology. Colloidal nanocrystals (NC) are ideal candidates for this application as they exhibit efficient, tunable emission and can be processed in solution. Their applicability is however hindered by nonradiative Auger recombination (AR), the difficulty of achieving balanced electron/hole currents in LEDs and small Stokes shifts which increase the losses by self-absorption. These issues can be addressed by engineering the confinement potential in NC heterostructures and through electronic doping. This project aims at combining these two strategies for achieving highly efficient, low-cost SSL devices that can be implemented in real-world technologies. This goal implies a dedicated synthesis effort and deep understanding of the physical and chemical processes occurring in the NCs and a strong multidisciplinary approach. The structural and optical properties will be investigated with advanced spectroscopic techniques some of which pioneered by the candidate. LEDs will be fabricated and optimized for maximizing their performance. The results will have strong impact on all aspects of NC research: 1) Development of synthesis protocols for producing NCs unaffected by AR and exhibiting new functionalities; 2) achievement of deeper understanding of the photophysical processes especially with regard to the role of interfaces on suppression of AR and the involvement of dopants in the recombination processes of NCs; 3) Design and realization of new SSL sources (white and monochromatic) also based on new operation paradigms made possible by the new functionalit