RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Charge transfer salts as molecular magnetic conductors' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content RESEARCH PROPOSAL  This research concerns the design and synthesis of new molecular compounds with coexistence of localized spins and itinerant electrons in strong interaction. In particular, associations of organic and inorganic blocks inside radical cation salts prepared from TTF and TCNQ derivatives have already given low temperatures magnetic insulators. It has been argued that in these low dimensional solids direct exchange interactions can occur and give rise to antiferromagnetic coupling at low temperature However, it appears that this strategy is limited and it would be more efficient to link directly by chemical bonds the donor organic part and the associated transition metals inside an hybrid molecule as in molecular magnets. Besides associated with intramolecular magnetic interactions, intermolecular indirect exchange could be introduced through the so called 'RKKY mechanism' which should be peculiar in these materials. The first step of this work will be therefore to synthesize robust metal complexes of ligands containing TTF (and TCNQ moieties), the second step will be to study the redox potentials of both the ligand and the metal with the possible occurence of intervalence transitions and then to prepare by electrocristallization new radical cation salts. After structural determinations we will study the magnetic and electric properties of these new materials. The creation of these new hybrid materials will favour the interplay of metallic conductivity and localized magnetism, and maybe lead to the formation of a molecular conducting ferromagnet. A further step would be in the future to examine the competition between a low temperature magnetic ordering and a superconducting state.  Training content (objective, benefit and e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Traces of Work: Developing human-centered design principles for leveraging digital traces of activity in knowledge work' (TRACE-WORK) under Horizon Europe.

assistant: **Objectives**

The TRACE-WORK project will study how traces of computer-mediated activities help knowledge workers carry out computer-supported cooperative work (CSCW). Digital traces such as change logs and timestamps provide cues that people use to interpret the state of work and connect back to previous activities. But there is no well-defined concept of traces in the fields of CSCW and human-computer interaction (HCI), and the role of traces in work has not been systematically explored. Due to this knowledge gap, there are no principles to support design for interactions with traces. There is a need, especially, for human-centered principles that consider the social impact of traces. The recent surge in remote and hybrid work has led to public concern over the role of technology in mediating people’s relationships with their workplaces; a topic that is severely understudied in CSCW. To address these gaps and establish traces as a practically applicable concept for the design of workplace technology, TRACE-WORK will develop a typology of traces, to be applied in an empirical study of knowledge workers’ practices and experiences of using traces. Building on this, the Researcher and study participants will co-produce design principles for traces. The researcher is uniquely positioned to successfully implement TRACE-WORK through her extensive knowledge in CSCW, her research on social dynamics in collaborative work, and her industry experience in producing design resources from research. Through TRACE-WORK, the Researcher will develop relevant skills; obtain and apply interdisciplinary knowledge; extend her professional network; and significantly expand her field’s understanding of a critical but understudied subject; thus building up a strong research profile of high relevance to her
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Traditional Knowledge for the Conservation of the Silk Roads Monumental Terracruda Sculptures' (TANTRiC).

assistant: **Innovation**

It is in Central Asia, that more than 2,000 years ago, the art of making monumental terracruda sculptures become one of the most significant expressions of knowledge transfer along the Silk Roads. Despite the wide distribution of this art and its historic relevance, we still lack a scientific understanding of the manufacturing of these sculptures. Consequently, preservation remains a challenge. Recent studies have shown that monumental terracruda sculptures are still produced in some areas of Himalaya (Bhutan) and India (West Bengal) and, although the precise materials may vary, the technological pattern remains unchanged over time. This pattern is the result of a specific knowledge acquired and transmitted over centuries. TANTRiC will study and valorise this traditional knowledge to unveil the cultural significance of this unique artistic practice, as well as to inspire, through scientific criteria, innovative and sustainable solutions for the conservation of these sculptures. TANTRiC proposes an interdisciplinary methodological framework in the domain of heritage science combining: ethnographic research, materials science and conservation. The objectives are: 1) documenting the empirical knowledge of making these sculptures, 2) analysing samples of archaeological sculptures to compare ancient and contemporary materials and additives, 3) carrying out a battery of simulations-tests to analyse the behaviour and properties of the clay-based mortars, inspired by traditional “recipes”. The expected results will be: a) improving the understanding, significance and evolution of the artistic practice of making monumental terracruda sculptures; b) enhancing and valorising the traditional knowledge for making these sculptures; c) informing new evidence-based conservation treatme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'XXX Meeting of the Euro Working Group for Financial Modelling'.

assistant: **Objectives**

The technological facilities that have changed our way of life in the last decade as the widespread use of internet as an information tool for neraly everybody requires an updating and implementation of more adequate financial modelling. This new era of information overflow requires models for describing the needs and preferences by means of efficient theoretical tools and methods to match the characteristics of the goods offered by the sellers and the good asked for by the buyers. So scientists will be asked more and more to develop multicriteria decision making models that will be able to describe the preferences of buyers or investors, or bank institutions when all the data needed and more will be available.In this context the use of reliable methodologies as well as ad hoc models to assess business failure represent one of the major aims of financial experts and applied mathematicians. European financial scientist is more and more required to share and discuss the need of updating classical optimisation models and to implement and validate new statistical and mathematical model in order to understand the continuously changing economic and financial world. The Meeting's aim is to provide a forum for European financial scientists, academics and practitioners, where a truly interdisciplinary approach is provided. The forum benefits all involved. Young researchers receive ideas and contacts with well known keynote speakers.Well known scientists may present recent research to an audience of their peers and may get benefits from discussions. Paper presenters receive constructive feedback on their work in a wide range of topics, as well as insurance and risk management, stock market behaviour, taxation and market imperfections, pricing and bargaining in financial markets,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Crivet Unemployed. The effectiveness of labour market oriented training for the long term unemployed' (1994-1998).

assistant: **Innovation**

The effectiveness of labour market oriented training programmes for the long-term unemployed arouses much interest among policy-makers as well as employers and unions. Nevertheless, there are doubts about the effectiveness of such training programmes which concern both the extent to which they serve its target group as well as the outcomes. The core aim of the project is to get a better understanding of what works and what doesn't work in training for the long-term unemployed through the comparative analysis and evaluation of such programmes.More specifically the objectives of the project are: 1) develop a set of hypothesis with regard to effectiveness; 2) test these hypothesis in order to identify the important parameters (e.g. organizational characteristics, contextual conditions); 3) develop a multilevel model (several parameter model) of effectiveness of training; 4) test its applicability in different European countries; 5) investigate and interpret the differences between countries; 6) provide decisions makers with recommendations for improvements of training programmes; 7) develop a monitoring instrument for individual managers of programmes to assess the effectiveness and quality of their own training programme. The work will be carried out by empirical elaboration of conceptual models by means of case studies of a restricted number of training programmes or schemes within each of the participating countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dissecting the protection mechanism of new generation vaccines by synchronizing systems biology with in vivo imaging' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Despite successful reduction of the burden of many infectious diseases by vaccination and the strong improvement of vaccine safety, there is a strong need to improve existing vaccines and to develop new affordable vaccines with greater efficacy. Particle-based vaccines are one of the recent advances, with potentially a promising impact on global public health. Besides being investigated for their protective potential, the knowledge about their mechanism of protection is still scarce. VacTrack is designed to investigate this by innovatively combining state of the art in vivo imaging with global transcriptome analyses. I aim to dissect the route vaccines acquire inside the host along with the spatio-temporal changes in gene expression following vaccine exposure to the host, by utilizing pneumococcal antigens grafted to outer membrane vesicles (OMVs) as model formulations in imaging-assisted in vivo mouse vaccination and challenge infection models. VacTrack is expected to generate insights about novel pathways triggered in host following vaccination which will be further validated by an ex vivo approach via stimulation of murine and human whole blood. By exploiting systems biology, high resolution in vivo imaging and immunological approaches VacTrack will provide a blue print for the approach to study mechanism of protection of vaccines in general. Comprehension of correlates of protection by combining in vivo and ex vivo analyses will  1) help devise new pneumococcal vaccines, 2) improve existing vaccine formulations, 3) transform the direction of vaccine research by allowing targeting of specific novel pathways identified via VacTrack. Taken together, this proposal holds great potential in advancing the vaccine research to devise new and better vaccines to save and impro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Beyond UV: Visible-light Photocatalysis in Prebiotic Chemistry' (BEYOND) targeting Horizon Europe.

assistant: **Abstract**

This proposal aims to uncover the role of visible light in driving prebiotic chemical reactions, with a focus on polymerizations and redox processes using prebiotically relevant photocatalysts. While UV light has traditionally been emphasized in prebiotic chemistry for its high energy and efficient bond-breaking properties, it can also degrade advanced organic material, presenting a central paradox in prebiotic chemistry. In contrast, visible light, when paired with photocatalysts, may drive important chemical transformations without the need for the protective mechanisms associated with UV chemistry.The project involves synthesizing a diverse range of photocatalysts to generate a computational model capable of predicting their photoredox properties. These molecules will then be investigated as photocatalysts in selected prebiotic reactions. Additionally, I will investigate key steps of a proposed prebiotic synthesis of key redox-active molecules can be initiated by visible light photoredox catalysis. Lastly, visible light-driven reactions will be benchmarked against established UV light-initiated processes to determine whether visible light can drive similar or complementary chemistry.By completing these objectives, I will provide examples of visible-light photocatalysis in prebiotic chemistry. This will impact our understanding of how visible light contributed to the formation of life’s building blocks, offering alternative pathways to prebiotic molecule accumulation and broadening our understanding of early chemical reaction networks.


**Keywords:** Prebiotic chemistry, photochemistry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Interferometric Microscopy and Nanoscopy in Live Biological Cells and Tissues' in the context of a Seventh Framework call.

assistant: **Objectives**

The current research proposes new optical spectroscopic and interferometric microscopy and nanoscopy techniques for accurate measurements and visualization of biological cell structure, organization, stiffness and dynamics by recording the cell spatial, temporal, and refractive-index structure on sub-wavelength and sub-Hertz scales. The following objectives are proposed:(a) Novel optical-mechanical signatures of cancer cells measured by wide-field digital interferometry: I propose to establish multi-disciplinary cancer biomarker using the stiffness signatures of cancer cells measured in a noncontact, quantitative and label-free manner by wide-field digital interferometry (WFDI).(b) Interferometric and spectroscopic diagnosis of red blood cell diseases: I propose to measure mechanical and morphological properties of live red blood cells (RBCs) with extremely high sensitivity in a non-destructive, noncontact and label-free manner, as a mean to learn about the biomechanical properties of the RBC membrane and as a novel diagnosis tool for diseases that change morphology and mechanical properties of RBCs.(c) Developing plasmonic-nanoparticle-based interferometric methods for Alzheimer's disease research: I propose to develop new nano-sensing and imaging modalities as a means to monitor degradation of neuronal function due to Alzheimer's disease. I will use photothermal optical coherence tomography with nanoparticles bound to amyloid beta to detect the degeneration in neuronal activity. This system will be combined with a low-coherence WFDI system for quantitative phase imaging of rapid dynamic neuronal phenomena.The proposed objectives are highly interdisciplinary, involving optical engineering, sensing in biological systems, biophysics, nanoscience, neurobiology, and diseas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The role of semaphorins and plexins in cancer progression and angiogenesis' (SEMAPHORINSANDCANCER), addressing dissemination and exploitation.

assistant: **Impact**

Members of the scatter factor receptor family (Met and Ron) are key regulators in tumour invasion and metastasis. It has been shown that receptor over-expression, as well as specific mutations can lead to the constitutive activation of these oncogenes, which correlates with cancer progression. Two novel protein families phylo-genetically related to scatter factor receptors have been identified, plexins and semaphorin. Semaphorins control cell migration by binding to plexins, which compose one group of semaphor in receptors and are implicated in the regulation of cancer progression. Semaphorins can also bind to the tyrosine kinase receptor Met and neuropilin.Intriguingly, neuropilins also function as co-receptors for Vascular Endothelial Growth Factors (VEGFs), which are important regulators of angiogenesis. This project is aimed to understand the functional role and mechanisms whereby semaphorin signalling can regulate cancer progression. The function of several semaphorins and semaphorin receptors will be investigated in vivo, by means of lentiviral-mediated gene transfer, in a model of cancer progression from local invasiveness to metastasis. We will screen a number of semaphorins, plexins and neuropilins expressed in various cancers that are either metastatic to the lungs, or have no tendency to metastasise.The transfected cell lines will be used to establish tumour xenografts.). Further mechanistic control of specific semaphorins/plexins will be studied by testing the tumourigenic and metastatic potential of cancer cell lines engineered for their regulated expression, or translational knock-down (RNAi), or by expressing their wildtype and mutated receptors. We expect that this functional screening will provide a broad view of the oncogenic or onco-suppressor potenti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Peptide Killers of Bacteria' to be submitted under Horizon 2020.

assistant: **Abstract**

Antibiotic-resistant bacteria cause more than 700 000 deaths per year, and the forecast is 10 million per year in 2050. Moreover, emerging strains of bacteria resistant to all available antibiotics may lead to a global post-antibiotic era. Because of this threat, the WHO and the UN are encouraging the research and development of new treatments. The aim of this proposal is to design new peptides that selectively target and disrupt the membranes of pathogens but not those of human cells. To obtain such peptides, we will develop an innovative coarse-grained model of membranes and an original growth method, which will enable us to establish the relationship between peptide sequence motifs and their affinity to membranes with specific lipid compositions. Moreover, we will determine the critical peptide properties required for membrane disruption via the formation of transmembrane pores and spontaneous peptide translocation across membranes by devising new collective variables capturing these processes. Our computational advances will be complemented by experimental verification from peptide-membrane affinity measurements plus leakage and flip-flop fluorescence assays assessing membrane disruption. The most effective peptides will be evaluated for antimicrobial activity and human cell toxicity using growth inhibition and hemolytic assays, respectively. We will investigate mixtures of peptides for their synergistic increase in antimicrobial activity, and we will uncover the molecular mechanism of their synergism. The peptide behaviour will be quantified under equilibrium and more biologically relevant non-equilibrium conditions. The methods and knowledge obtained within this project will not only enable us to determine new peptides selectively killing bacteria, but will also e