RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Z phase strengthened steels for ultra-supercritical power plants'.

assistant: **Innovation**

The aim is to develop a heat resistant steel with a 100 000 hour creep strength of 100 MPa at 650°C. This allows increasing the thermal efficiency of fossil power plants to over 50%, which is 30% higher than the present standard in most existing power plants. The CO2 emissions are reduced accordingly. The consortium combines the expertise of a steelmaker, two utility companies, an engineering consultant company from Ukraine and eight research organizations and universities from EU and Eastern Partnership countries.The idea is to exploit the Z phase as a thermodynamically stable strengthening agent in martensitic creep resistant steels. Previously the Z phase has been considered as detrimental, since the coarse Z-phase particles that develop during long time service in high-chromium steels hardly contribute to the strength while growing at the expense of the fine, strengthening nitride particles. However, high chromium contents around 12% are needed, since the current 9% chromium steels do not provide sufficient oxidation resistance at 650°C. Hence the challenge is to control the precipitation of the Z phase in 12% Cr steels such that fine Z particles are formed, which are stable for long times. An important aspect is that the beneficial microstructure should be established also by the post-weld heat treatment.To achieve the goal, test melts containing different alloying elements are prepared and subjected to different heat treatments. Welding consumables and processes are also tested. Since a purely empirical alloy development is time consuming and costly, the process is supported by microstructural investigations on an atomic scale. Similarly, multiscale modelling methods are developed and applied to Z-phase strengthened steels. Modelling not only enhances the fundamen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Motivic integration, exponential sums, and the langlands programme' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

We will develop further the theory of motivic integration. This will be done in collaboration with Prof. F. Loeser (Ecole Normale Superieure, Paris). The aim is to develop a theory of motivic integration for exponential sums and exponential integrals, which will roughly be a universal way of calculating families of (parameterised) sums of complex numbers. This will be of immediate use for the Langlands programme, since one can prove the fundamental lemma in the form of the conjecture of Jacquet-Ye over the p-adic numbers for p big enough using this theory.It will also be of use for cryptography and theoretical physics since counting points and calculating sums are crucial tools in cryptography and since alternative theories of integration gain more and more interest by physicists. Such a theory of motivic exponential sums is completely absent and will be central in number theory, algebraic geometry and model theory. It fits into the objectives of the programme since this theory combines several discipline s of mathematics and is applicable in other domains such as cryptography and physics.Also, the stay at the top-level place Ecole Normale Superieure will widen my researchers' career prospects and will widen my researcher's experience and expertise to great extend. Moreover, this project will promote excellence in European research, since I have proven to be a high-impact researcher with high-impact publications and international collaborations, who has given invited talks at top-universities such as Oxford -University and the Fields Institute and during top-conferences. To build such a theory is within reach in this project, because of previous work by Cluckers and Loeser on (parameterised) motivic integration and because of the world-leading expertise of bot h Clucker
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Workshop to develop European cancer control planning instruments followed by the creation of a network of cancer control plan partners within a European Union' in the context of a Fifth Framework call.

assistant: **Objectives**

In Europe, there is a great variation in cancer care and in survival of cancer patients with similar cases. (Eurocare study, IARC). The type of intervention is the main cause ot these variations There are indications that countries with comprehensive cancer care services and an established co-operation between health care professionals provide better health and survival outcomes.These outcomes in mean survival time can vary from 10 to 20%. This as a major impact on cost for treatment and care. It also induces inequalities in health and social status. A cancer control plan promotes common services, standardised data collection and compilation, exchange of experience between health professional and between structures on the most effective practices as well as experience on quality assurance and quality control. The intention is to initiate cancer control plans throughout Europe and launch the discussing of this concept in a symposium.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Molecular analysis of the mechanisms linking co-transcriptional splicing with chromatin'.

assistant: **Concept**

The project will exploit recent work in Arabidopsis (in the Dean laboratory) linking RNA metabolism and chromatin silencing (Liu et al 2009). The Dean group is focused on RNA-mediated chromatin regulation of an important repressor of flowering called FLOWERING LOCUS C (FLC). The concepts that have emerged from this study have wide relevance in many organisms. Conserved RNA 3’ processing factors function with an RNA-binding protein to target polyadenylation to a specific site in the FLC antisense transcript. This 3’ processing event triggers histone demethylation and transcriptional silencing of the locus. Their unpublished work shows that a conserved splicing factor, specifically PRP8, a core component of the spliceosome, also functions in this mechanism. The overall aim of the proposal is to reveal the molecular mechanism of involvement of splicing factor PRP8 on anti-sense RNA dependent regulation of transcription of FLC in Arabidopsis and to test generality of that mechanism on other anti-sense regulated genes.The specific objectives of the proposal include:1.Fully characterizing the FLC antisense transcript changes in the splicing factor mutant (prp8) mutant.2.Analysing the contributions of RNA degradation pathways in the accumulation of FLC antisense transcripts in wild type and in prp8 mutant backgrounds.3.Analysing the interactions between splicing and 3’ processing of the antisense transcripts.4.Generating and analysing directed mutations in PRP8 to explore whether the prp8 allele generated in the forward mutant screen is hypomorphic or has lost a specific function but is still wild-type for generic splicing functions.5.Analysing the components of the RNP complex that are assembled on the antisense transcript.A better understanding of the flowering control of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integrated highly sensitive fluorescence-based biosensor for diagnosis applications' (INDIGO) under Sixth Framework.

assistant: **Objectives**

Biochip technology allows assessing the expression of thousands of genes in parallel, opening the way to individualised healthcare. The INDIGO project will replace the current bulky and expensive technology used to hybridise and read fluorescent biochips by a lab-on-chip approach, with integrated signal processing and networking capacities. The project reconsiders the complete biochip user chain, and optimises each component in relation to others.At the core of INDIGO is an innovative, miniature and highly sensitive, yet disposable fluorescence-based biosensor. It replaces the usual glass slide supporting the biological reaction by a sandwich of chemical and optical layers monolithically grafted on a CMOS or CCD image sensor. Intermediate layers play an essential optical role for guiding and filtering light. The upper side of the sensor is devoted to biology, the lower side to imaging by direct, and efficient light collection by the pixels. Improving signal level will enhance the sensitivity and robustness of the biological measurements.Such a lensless imaging device produces images with new characteristics and needs development of new data processing software. The image produced by the sensor will be read in a laptop-connected readout head, and then filtered, segmented and measured; the results will be normalised, written in a standard format, ready to be recorded into a database or transmitted through networks.With its user-friendly interface, the system will undergo clinical validation in biology labs, on samples from patients with different cancers and cardiovascular diseases. The INDIGO project is well suited to the joint IST and NMP call on biosensors for Diagnosis and Healthcare. On the NMP side, smart and hybrid materials like sol-gels with extreme characteristi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'True Minimally Invasive Spinal Fusion System' (ZygoFix) under Horizon 2020.

assistant: **Objectives**

Back pain is one of the most common medical problems worldwide. More than 632 million people worldwide suffer from low back pain what becomes a frequent self-limiting condition. When conservative treatments are not effective, surgical intervention is usually sought after to reduce pain and restore quality of life. The most common surgical procedure is the spinal fusion where two or more vertebra are fused together to stabilize the affected vertebral segment, relieve pressure on the nerves and relieve pain. Published estimations have calculated that 699,318 lumbar spinal fusion procedures occurred worldwide in 2017. Current procedures utilize screws and rods to construct an external “bridge” that connects between the vertebrae. This solution is costly, highly invasive and can lead to complications resulting in re-operations when screws are misplaced. Our new and unique zLOCK Facet Fusion System is a fixation device for lumbar spine fusion surgeries that utilizes the natural anatomy of the spine allowing for shorter and less invasive surgery that doesn’t use screws or external constructs. Our zLOCK system is made with an innovative 3D printing technology to provide a safer implant that fits any facet anatomy (any patient) and a more cost-effective solution for lumbar spinal procedures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Automatic Rail Safety Solution' in the context of a Horizon 2020 call.

assistant: **Objectives**

By 2025 1800km of rail lines will be automated worldwide. With the increase in automatic train operation comes the need to create an innovative platform and track protection system to ensure the security of passengers while maintaining increased efficiency in public transport. According to the European Railway Agency in 2012 there were a total of 5122 railway incidents involving people across Europe of which 1016 were serious injuries, 1133 were deaths and 2973 were suicides. The combined costs of fatalities and serious injuries cost the EU more than 1.5 billion euros in 2012. SDO-MET (Metro Object Detection System) is an innovative technology that aims at helping usher in the next era in automated public transport. Our platform and track security system provides a safer, lower cost, and easier to install alternative to current systems. Using an innovative system of sensors and cameras our goal is to make metro platforms and track areas safe and efficient for users and operators of automated trains. Our goals for phase 2 are to further develop and refine SDO-MET in order to have a market ready product. Our main focus, on a technical level, will be the implementation of the two SoA visual systems necessary for SDO-MET. The potential customers are the main operators of the railway sector such as Barcelona Metropolitan Transport, Metro de Madrid and Brussels Metro with whom we currently have trade relations. Other potential customers include project engineers and manufacturers /distributors of railway equipment such as SIEMENS, BOMBARDIERS, THALES, etc. During the development of our first prototype over the past 5 years we have developed a business plan and commercialization strategy. These and other feasibility activities, along with the willingness to pay already express
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Modelling the mechanisms of nanoparticle-lipid interactions and nanoparticle effects on cell membrane structure and function', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The central goal of our proposal is to develop physically justified models and computational tools to quantitatively describe and understand the molecular mechanisms of nanoparticle-cell membrane interactions, which we consider to be a crucial point in any predictive model of nanoparticle toxicity. We consider mechanisms of nanoparticle protein corona formation, the protective function of the membrane, nanoparticle uptake into the cell, and the effect of nanoparticles on the cell membrane. We plan to develop a consistent multiscale simulation scheme starting from nanoparticle-biomolecule interaction at the atomistic scale using molecular dynamics simulation, and then systematically constructing coarse-grained mesoscale models for simulating the structure and dynamics of the cell membrane perturbed by nanoparticles at the physiologically relevant time and length scales. We will develop and test a universal method for evaluating the rates of nanoparticle translocation through membranes and evaluate associated specific toxicity effects. Based on the information acquired from the simulations and analyzed together with available experimental data, the toxicological impact will be deduced. We will apply our approach to a range of common engineered nanoparticles, relating their physicochemical properties such as size and shape, surface charge, hydrophobicity (logP), and plasma protein binding affinity to the toxicological effects and develop a test suite allowing to make toxicity prediction on the basis of purely computational or limited in vitro screening tests.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Roles of genetics and environmental variability in animal population resilience: empirical testing in a changing world' (DisperseAdaptSurvive).

assistant: **Concept**

Current climate change is threatening biodiversity more than ever due to the speed at which climate variables are shifting. Coupled with omnipresent land-use change, they are the two factors considered as the most important threats to terrestrial biodiversity. Very little is known of the respective joint contributions of climate change and habitat heterogeneity on the genetic make-up of natural vertebrate populations, which ultimately act on gene flow, genetic structure, and evolutionary adaptation simultaneously. The aim of this project is to determine the respective roles of climate variation and habitat heterogeneity as key factors modulating (i) population genetic diversity and levels of gene flow across populations, and (ii) response to natural selection on key life history traits using contrasted but complementary analytical methods in a wild passerine bird. This proposal will use a unique long-term study of several natural populations of blue tits Cyanistes caeruleus breeding in a mosaic of highly heterogeneous environments and monitored in Southern France and Corsica for the past 35 years. I will use a combination of approaches drawn from distinct fields in biological sciences, such as Next Generation Sequencing (NGS), a Geographic Information System (GIS) and an analysis of climatic data. Coupled with a population and quantitative genetics approach, as well as statistical modelling using multi-state recapture models, I will generate an integrated picture of the interactions between environmental change (habitat and climatic) and genetic variability in wild, natural blue tit populations. Finally, and in collaboration with the Forest Biodiversity department of the United Nations Food and Agricultural Organisation, (iii) a meta-analytical approach will be taken to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Physics at TeV Colliders' (1998-2002).

assistant: **Concept**

Background: The Large Hadron Collider (LHC) under construction at CERN will open up an entirely new domain in the exploration of the structure of matter at the smallest possible scale. The discovery of many new particles at LHC will shed light on one of the fundamental issues in elementary particle physics: the understanding of the dynamics responsible for the electroweak symmetry breaking (what triggers the differentiation between electromagnetism and beta radioactivity whereas they come from the same interaction at high energy?), and the origin of masses of elementary particles (why are elementary particles massive, why are their masses so different?). These issues also have cosmological implications for the history of the early Universe.Content The dominant theme of the School is the study of the observable consequences of possible electroweak symmetry breaking patterns and their signatures in the complex detectors of the LHC experiments ATLAS and CMS. The topic is therefore at the interface between theory and experiment. Starting from the results of the phenomenological analysis of present data (LEP at CERN and Tevatron at FERMILAB, USA), strategies will be developed to understand how future experimental results will unravel possible patterns of symmetry breaking.Objectives The proposed school aims at preparing young physicists, both theoreticians and experimentalists, to the analysis and interpretation of data to be collected at the LHC when it starts operating in 2005. The problems to be studied are: what are the signals of new physics? Could they be hidden by the background? How to optimise these signals? Various analytical and computational tools will be used and applied to specific cases.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00353-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Information technology for food production' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

SMEs within the food production industry have traditionally been 'low-tech' operations and therefore often operate under non-optimum conditions. Taking advantage of advanced IT is essential to retain the competitiveness of European companies against foreign rivals. Efficient use of advanced IT solutions would allow SMEs to increase productivity, return and ensure environmentally safe operation as well as optimising the use of natural resources. The principal objective of IT-FOR-FOOD is to implement advanced IT which will permit European SME food production companies to improve the productivity of their operations in parallel with fulfilling the demands of the EU regarding own checks and environmental issues.The systems will specifically use IT to include measures for resource, waste and energy management, thus enhancing the industry's capabilities for environmentally friendly production. The project includes specific training measures within the producing SMEs concerning management and IT, related to optimising production methodologies. The project will elevate traditional production facilities to flexible concurrent production environments, and exploit IT-based business integration both within the production companies as well as on an inter-company level, up to the level of distantly located SMEs operating together as a single company. The project will lead to innovative use of state-of-the-art technology by assessing how companies within the food production industry can use IT better, as well as implementing IT solutions on a trial basis.