RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'T-cell-induced immune programming and degeneration of the neuronal tissue during chronic autoimmunity' in the context of a Horizon 2020 call.

assistant: **Objectives**

The TOPIC of this proposal is how a T-cell-driven autoimmune process can transform the brain into a chronically inflamed tissue afflicted by progressive neurodegeneration. The brain is considered to be an immune-privileged organ because immune cells have restricted access to its tissue and its resident cells can only exert limited immune functions. However, in the course of multiple sclerosis, a T-cell-induced chronic autoimmune disease of the brain, such aspects change dramatically and the brain tissue is transformed into an immunoactive milieu. These changes go hand in hand with a gradual degeneration of the neuronal tissue. What steers this transformative process in the brain is not yet understood.  We have developed new experimental models and tools that enable us to follow and functionally test this transition from healthy into degenerating brain tissue in real time. We found that autoaggressive T cells within autoimmune lesions were frequently in direct contact with neurons or were partially or even completely inside the cytoplasm of neurons. Repeated T-cell-mediated autoimmune attacks of the CNS grey matter induce persistent inflammatory lesions with proceeding neurodegeneration. This leads us to the HYPOTHESIS that T cells not only trigger the initiation of autoimmune disease bouts but in addition directly contribute to the chronification of the disease by irreversibly shifting brain resident cells to an inflammatory program. The central AIM of this project is to uncover the mechanisms behind this T-cell-induced neuronal transformation process, particularly the functional consequences of the T-cell invasive behavior. Our VISION is to shed new light on this previously unknown function of autoaggressive T cells within the CNS tissue and thereby pave the way for ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The role of degradation pathways on cell stemness and fate determination' to be submitted under Horizon 2020.

assistant: **Abstract**

The haematopoietic system relies on the potential of haematopoietic stem cells (HSCs) to self-renew and differentiate into all lineages of mature blood cells, and is a reference model to study differentiation hierarchies. Cell fate determination results from different layers of regulation, including transcriptional, translational, epigenetic, metabolic, and cell biological changes. Degradation pathways, such as autophagy and the proteasome, play mechanistically relevant roles that in principle may impact on all these layers. Indeed, catabolic degradation results in the building blocks necessary for anabolic processes, while it also preserves stemness and regenerative potential. Asymmetric cell division (ACD) has been extensively reported to contribute to maintenance of stemness by the rise of daughters with divergent fates in stem cells, including HSCs. Taken together, I postulate that degradation pathways work synergistically to give rise to the asymmetric fates observed in HSCs differentiation and can be targeted for future therapeutic use in humans. I plan to test this by 1. establishing an efficient strategy to image asymmetric inheritance of cargo by long-term ex vivo HSCs expansion, 2. verifying whether autophagosomes and proteasomes are co-inherited in HSCs mitoses, and 3. assessing the impact of cargo segregation by ACD on HSC maintenance and differentiation. I will use state-of-the-art techniques and novel murine models to assess the molecular and cell biological mechanisms of ACD modulation on HSC maintenance, relying on imaging of known and potentially novel components that are asymmetrically inherited by HSCs and able to impact their fate determination. Finally, I will further evaluate the in vivo impact of cargo inheritance on haematopoiesis by using single
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'By the Rivers of Babylon: New Perspectives on Second Temple Judaism from Cuneiform Texts' (BABYLON), addressing dissemination and exploitation.

assistant: **Impact**

This project has the potential to radically change current understanding of cultic and social transformation in the post-exilic temple community of Jerusalem (c. 6th-4th centuries BCE), an important formative phase of ancient Judaism. “BABYLON” draws on recent, ground-breaking advances in the study of cuneiform texts to illuminate the Babylonian environment of the Judean exile, the socio-historical context which gave rise to the transformative era in Second Temple Judaism. In particular, these new data show that the parallels between Babylonian and post-exilic forms of cultic and social organization were substantially more far-reaching than presently recognized in Biblical scholarship. “BABYLON” will study the extent of these similarities and explore the question how Babylonian models could have influenced the restoration effort in Jerusalem.This goal will be achieved through four sub-projects. P1 will study the social dynamics and intellectual universe of the Babylonian priesthood. P2 will finalize the publication of cuneiform archives of Babylonian priests living in the time of the exile. P3 will identify the exact areas of change in the post-exilic temple community of Jerusalem. P4, the synthesis, will draw from each of these sub-projects to present a comparative study of the Second Temple and contemporary Babylonian models of cultic and social organization, and to propose a strategy of research into the possible routes of transmission between Babylonia and Jerusalem.The research will be carried out by three team members: the PI (P1 and P4), a PhD in Assyriology (P2) and a post-doctoral researcher in Biblical Studies specialized in the Second Temple period (P3 and P4). The participation of the wider academic community will be invited at two moments in the course of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'The virtual cast house", development of a process chain model of aluminium direct chill casting of tailored products (VIRCAST)"'.

assistant: **Innovation**

The project aims at providing European aluminum producers with a powerful tool, the Virtual Cast House", a process chain model, which will make process optimization in the cast house more efficient and economical. With this tool the cast houses keep their present competitiveness by providing tailored products of superior quality to its customers with minimum environmental impact on the European society. It will be the tool to give the cast houses the means to change the metal basis of high quality products from a primary metal alloy systems to a more recycled material base. The project brings together six major European aluminum producers, six leading universities and research institutes and one software developer. Fully integrated models will be developed for hot tearing and microstructure development during casting and homogenization, which are the phenomena that determine the productivity and product quality. The models will be verified by laboratory and full-scale experiments."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'seCUre and pRivate hEalth data eXchange' (CUREX), addressing dissemination and exploitation.

assistant: **Impact**

The Health sector’s increasing dependence on digital information and communication infrastructures renders it vulnerable to threats to privacy and cybersecurity, especially as the theft of health data has become particularly lucrative for cyber criminals. At the same time, a breach of integrity of health data can have dramatic consequences for the patients affected. CUREX addresses comprehensively the protection of the confidentiality and integrity of health data by producing a novel, flexible and scalable situational awareness-oriented platform. It allows a healthcare provider to assess the realistic cybersecurity and privacy risks they are exposed to and suggest mathematically optimal strategies for addressing these risks with safeguards tailored specifically for each business case and application. CUREX is fully GDPR compliant by design. At its core, a decentralised architecture enhanced with a private blockchain infrastructure ensures the integrity of the risk assessment process and of all data transactions that occur between the diverse range of stakeholders involved. Crucially, CUREX expands beyond technical measures and places emphasis also on improving cyber hygiene through training and raising awareness activities for a healthcare institution’s personnel. Its validation focuses on the highly challenging condition of (cross-border) health data exchange, spanning patient cross-border mobility, remote healthcare, and data exchange for research. CUREX consortium will also utilise the outcomes of the well-known MyHealthMyData project in a dedicated demonstration that will use their blockchain-enabled platform which will control the actual data exchange. We envisage that CUREX will impact the European market developing one of the first blockchain platform for risk as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A scientifically proven, safe, naturally derived drug for the effective treatment of liver damage - an innovative solution for a significant unmet medical need'.

assistant: **Objectives**

Non-alcoholic fatty liver disease (NAFLD) is a condition in which fat builds up in the liver causing inflammation and eventually lead to permanent scarring (cirrhosis), which can seriously impair the liver’s ability to functions. NAFLD can progress to non-alcoholic steatohepatitis (NASH), and then to liver failure resulting in death unless there is a liver transplant. The prevalence of NAFLD in Europe is estimated to be between 26 and 33% of the general population. Currently, there is no available therapeutic treatment for patients with NAFLD and NASH. Natural Shield have developed a specialised oral therapeutic, called SULIPRO, which is a combination of soy derived compounds, that has been proposed as a novel scientifically proven safe treatment for patients in the early stages of NAFLD and NASH.  Current drugs produced for liver diseases have a large amount of side effects and high financial costs that may preclude their long-term use in patients with NAFLD or the early stages of NASH. SULIPRO has already undergone positive clinical trials in animal models and successful Phase I clinical trials in humans showing demonstrating no side effects and high efficacy. The company now requires funding for a small Phase II trial. Once commercialised SULIPRO will be made available to consumers at an affordable price, as an over the counter (OTC) drug, available in shops/pharmacies and on the web, using an online distributor, such as Amazon. Natural Shield maintains its own research program involved in developing in parallel OTC food supplements, physician-prescribed medical foods, and FDA-approved botanical drugs. The company expects to reach the market with its first products within 24 months and thus far has raised over 5 million EUR in private funds.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ontogeny of enteric neurons' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The objective of this proposal is to investigate a number of important processes which occur during the development of neurons within the enteric nervous system. Consequently, the proposal consists of three projects, each of which overlapp by utilizing chimeric embryos and/or organotypic culture methods in conjunction with immunohistochemistry. Project 1 will investigate neural crest cell proliferation within chick- quail chimeric embryos, using antibodies directed against quail cells, and the mitotic cell marker BrdU. Results will provide information concerning the location and time period when crest cell proliferation occurs. Project 2 will investigate the potential role of chemoattraction in the gut by utilizing genetic mutant mice, lacking certain receptors and ligands. Segments of gut from these animals will be cultured in association with quail ganglia to DETERMINE if the quail cells are chemically attracted in the absence of ligands/receptors. In project 3, the development of interstitial cells of Cajal will be examined in aneural gut to DETERMINE if these network forming cells are capable of developing their normal phenotype in the absence of neurons with which they are closely associated. Although the time course for neural colonization of the gut is well established, the results obtained from these projects will contribute new information concerning the migration and proliferation of developing neurons and their effect on other cells. In the course of this project, the candidate will utilize familiar techniques in addition to embryological methods, such as the chick-quail marker system, chorioallantoic membrane grafting and organotypic culture methods to address important developmental issues within the enteric nervous system. The utilization of these powerful
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Category theory for meaning assembly and the semantics-pragmatics interface' under Seventh Framework.

assistant: **Concept**

The project investigates the interaction between semantic and pragmatic factors in determining the meaning of an utterance, particularly how the factors can be unified in a single account of meaning. Addressing this question is important for two reasons. First, semantic and pragmatic approaches to natural language meaning have diverged into two separate fields, with independent sets of assumptions. While this has been useful in uncovering a number of phenomena, many scholars have pointed out that the division is artificial and prevents linguistic theory from properly exploring a large number of central phenomena in natural language at the intersection of the two dimensions of meaning. Second, a better integration of semantics and pragmatics will have significant practical consequences both for linguistics and for applications in industry. Currently, any attempt at combining semantic and pragmatic approaches is a daunting task, as the interactions between the two aspects are poorly understood. This also has the effect of limiting computational systems for deep understanding of linguistic input. Given the increasing ubiquity of voice interface systems, improving our understanding of these interactions is a priority.The project will have three goals. The first is to investigate the viability of the mathematical framework of category theory for richer formal models of meaning. I have already obtained promising initial results with this method for some phenomena. I intend to study its applicability to a wider range of phenomena. The second goal will be the implementation of a prototype computational system based on the results of the first goal. The formal system will be implemented as an extension of the Xerox Linguistic Environment and made available to the research and in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'New cloud-base SW for ensuring the Cold Chain during Food Transportation'.

assistant: **Innovation**

Traceability is a risk-management tool which ensures that all food products in the EU are safe. Traceability gets even more crucial when products must be kept refrigerated. The cold chain logistics is currently facing several challenges: (1) food waste, with over 88 million tons of food waste annually in Europe (equivalent to €143 billion) due to improper storage of temperature sensitive products which causes, (2) There is a lack of interconnection among food companies regarding traceability information systems what causes labelling errors, and (3) even more restrictive EU regulations and certifications on food security and quality. SW & Technology represents one of the fastest-moving, promising and disruptive segments in the business and consumer worlds today. Digital innovations are going to be key in the global logistics market that is set to grow at a CAGR=7.5% in the period 2015-2024 surpassing the €15 trillion in revenues in 2023. Under this context Zuffellato, an Italian SME with some solutions in the food tracebility sector, is finishing the development of Coldtrack: an integrated Information System for RFID-enabled traceability and temperature monitoring providing real-time, full, verifiable and easily available traceability across the whole food supply chain in a cost effective and efficient way. The core of ColdTrack is our Big Data supporting online platform that contains all the information on each unit as well as a continuous temperature-monitoring and warning system. In addition, a free application for smartphones will make relevant information available in a simple and friendly format for end consumers. Thanks to ColdTrack, at Zuffellato we will consolidate our presence in our home market (Italy) and become a relevant actor in this market segment in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Transmission Electron Microscopy Studies of Charge-Density Waves in YBa2Cu3Oy and ErTe3' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Understanding high-temperature superconductivity in cuprates is arguably the hardest problem in condensed matter. Active research in the pastten years has shown that a successful microscopic theory of superconductivity will need to describe other electronic phases that emerge alongside superconductivity. One of those electronic phases are charge-density waves (CDWs). We propose a novel approach to study CDWs and their competition with superconductivity down to the atomic scale using Transmission Electron Microscopy (TEM) and ultrafast TEM (UTEM) at cryogenic temperatures in the particularly clean cuprate YBa2Cu3Oy. These techniques are very sensitive to the periodic lattice distortion (PLD) that results from the coupling between the CDW and the lattice. Being able to study CDWs at the atomic scale, we will achieve a complete picture of the CDW properties in real-space that goes beyond what has been uncovered by X-ray diffraction and Nuclear Magnetic Resonance (NMR).Firstly, this will allow to study whether CDWs are correlated with disorder or vice versa.Secondly, by applying uniaxial strain we will enter the long-range CDW phase and investigate whether the PLD is truly incommensurate or whether repeated discommensurations shift the CDW wave vector away from a commensurate value, as has been suggested by NMR.Thirdly, using UTEM and photo-excitation within the superconducting state we will have the chance to observe the competition of CDWs with superconductivity in real-space at the femtosecond time scale.Before studying YBa2Cu3Oy, we will investigate a CDW model system, the transition metal trichalcogenide ErTe3.These two materials have a number of similarities. Both these studies will advance the understanding of charge-density waves. This novel approach will establish
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Targeted gene delivery in the prevention of restenosis after balloon angioplasty'.

assistant: **Concept**

The purpose of this project is to construct a plasma stable lipoplex, containing either a repoter gene or a model anti-sense oligonucleotides designed to selectively deliver the gene or the ODN to smooth muscle cells in the aorta of rats that has been damaged by balloon catheterisation.