RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Low-noise, rapid and ultrabroadband terahertz time-domain ellipsometry enabled by spintronic terahertz emitters' in the context of a Horizon Europe call.

assistant: **Objectives**

Electromagnetic radiation in the terahertz (THz) frequency range (0.3-30 THz) is a powerful tool for material spectroscopy and characterization in a contact-free, non-ionizing and non-destructive way. An essential application is the contact-free measurement of the complex-valued reflectivity and, ideally, refractive index of materials. Such knowledge is essential in condensed-matter research (for characterization of, e.g., the conduction-electron concentration and scattering in semiconductors, of optical phonons in insulators and magnons in antiferromagnets) and in applied settings. Ideally, THz reflectivity measurements should be (1) ultrabroadband (covering two decades from 0.3 to 30 THz), (2) user-friendly and offer (3) high precision and low noise. However, requirements (1)-(3) are not fulfilled by current approaches. The goal of T-SPINDEX is to build a prototype THz time-domain reflectivity spectrometer to determine the THz refractive index of materials rapidly. Features (1)-(3) are achieved altogether by using an innovative laser-driven coherent THz source, a spintronic THz emitter.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enantioselective synthesis of antitumor active 7 alpha-substituted steroids' (1994-1998).

assistant: **Concept**

Task 1: 2,3-disubstituted cyclopentanones with vinyl groups at C-3 should be prepared via an asymmetric Tandem 1,4-addition/ Dieckmann cyclization. Task 2: The diastereoselectivity of the Claisen rearrangement of chiral propargyl enol ethers towards 2,2,3-trisubstituted cyclopentanones should be investigated. Task 3: The proposed synthesis of 7a-substituted steroids should follow the D-> ABCD approach which has not been accomplished yet. The ring D building block has to be connected with an alkyne side chain forming an enediyne. A diastereoselective cobaltmediated cyclization of this enediyne should afford the steroidal skeleton with 7a-configuration. This steroid should be converted into biologically active steroids with antitumor activities. Task 4: Starting from a key intermediate which allows the introduction of unnatural substituents at C-7 on a very late step of the synthesis a variety of 7a-substituted steroids should be prepared. The pharmacological properties of these new unnatural steroids should be investigated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Europe-India Partnership for Scientific High-Performance Computing', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

High-Performance Computing (HPC) is a major enabler of progress in many domains of science, including UN Sustainable Development goals towards improving population health and climate action. HPC is driving breakthroughs in genomics, drug discovery, and personalized medicine, as well as geophysical hazard simulations, improving preparedness for disasters like earthquakes and tsunamis, and supports weather and climate predictions. Europe is among the world leaders in HPC and with initiatives such as EuroHPC JU is advancing the usage of exascale computer systems for research. India is expanding its HPC capabilities through the National Supercomputing Mission, focusing on indigenous technology and fostering academic, industrial, and governmental collaborations. Combining Europe’s advanced infrastructure with India’s growing expertise offers opportunities for innovation in those strategic areas of climate modeling, disaster management, and healthcare. Shared resources and expertise can enhance predictive models, accelerate responses to pandemics, and foster technological and economic growth.The GANANA project is establishing a long-term partnership collaboration by uniting European HPC centers of excellence (BioExcel, ChEESE, ESiWACE3) and Indian institutions (C-DAC, IMD, ISR, NII, AIRAWAT) with the objectives to:•Strengthen the links between research communities in the priority domains by supporting existing and establishing new collaborative activities. •Setup and operate a range of activities in support of expertise exchange, capacity building and sharing of computing resources.  •Develop selected leading software packages by extending their functionality, optimise HPC performance and scalability, deploy on target architectures, improve usability and data integration.•Exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'TEST STRATEGY FOR ETCS BASED ON THE PILOT INSTALLATION VIENNA-BUDAPEST' under Fourth Framework.

assistant: **Concept**

The project ETCSVB has the main objective to set in place a pilot installation of the ERTMS, Level 1, on the Vienna-Budapest line. This first complete installation as an overlay on an existing line shall demonstrate the performance of the new European train control system and the interoperability with existing ATP systems, and shall lead to an approval or revision of ERTMS specification for subsequent wide application on the railway network in Europe.By the accompanying research work in this project and by the step-by-step approach of implementation, the risks while introducing innovations to a complex system should be minimised.The full functional system validation shall be performed for the following operating modes/functions:* full ERTMS Level 1 will be tested according to European functional Specification (FRS),* the STM Indusi developed in other projects will be used in this project, if available,* Infill function will be fulfilled for  - MAV by the EVM transmission channel and for comparison in two sections with Euroloop, if available, or else by an equivalent solution with balises, - ÖBB by Euroloop, if available, and/or by Eurobalises.* a standardised, available ERTMS MMI will be used on the Vienna - Budapest test site.Contribution to the ERTMS generalisation in Europe and in the third country (PECO)Links with other projects, tasks, areas, programmes, policy actions: ERTMS - Master Plan Directives 96/48 on InteroperabilityCase studiesImplementation of ERTMS Level 1 on 70 km of the Vienna-Budapest line.Specification 3/98
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SAGE' (SAGE).

assistant: **Concept**

Worldwide data volumes are exploding and islands of storage remote from compute will not scale. We will demonstrate the first instance of intelligent data storage, uniting data processing and storage as two sides of the same rich computational model. This will enable sophisticated, intention-aware data processing to be integrated within a storage systems infrastructure, combined with the potential for Exabyte scale deployment in future generations of extreme scale HPC systems.Enabling only the salient data to flow in and out of compute nodes, from a sea of devices spanning next generation solid state to low performance disc we enable a vision of a new model of highly efficient and effective HPC and Big Data demonstrated through the SAGE project.Objectives- Provide a next-generation multi-tiered object-based data storage system (hardware and enabling software) supporting future-generation multi-tier persistent storage media supporting integral computational capability, within a hierarchy.- Significantly improve overall scientific output through advancements in systemic data access performance and drastically reduced data movements.- Provides a roadmap of technologies supporting data access for both Exascale/Exabyte and High Performance Data Analytics.- Provide programming models, access methods and support tools validating their usability, including ‘Big-Data’ access and analysis methods - Co-Designing and validating on a smaller representative system with earth sciences, meteorology, clean energy, and physics communities- Projecting suitability for extreme scaling through simulation based on evaluation results.Call Alignment:  We address storage data access with optimised systems for converged Big Data and HPC use, in a co-design process with scientific partners and app
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Design, structural testing and cost effectiveness of sectional wind turbine blades' in the context of a Fourth Framework call.

assistant: **Objectives**

As wind turbines are designed and constructed to ever increasing sizes, so the component sizes must increase in proportion. In the case of the blades, for MW scale machines, handling and transportation start to become major problems since, for example, the road clearance beneath bridges is no longer sufficient. One solution would be to design blades in sections which were then assembled on site. Such a technological development would also facilitate the exploitation of remote sites, especially those with complex terrain. However, it is of prime importance that structural integrity and blade performance are not diminished by the connection between different sections and that any extra costs incurred by the design are less than the subsequent savings. This project therefore proposes to take a comprehensive look at possible connection designs - developed from state of the art blade root connections and more innovative light aircraft wing joints - to test the most promising, and then to design and build a prototype sectional blade. This would then be tested for both static and fatigue strength and the results compared with the equivalent conventional blade design. The implications for manufacture, transportation, construction, and blade repair will be fully assessed and included in an assessment of the cost effectiveness of the concept. The main innovation, therefore, will be to produce a modular blade design and to demonstrate its reliability with respect to strength (static and fatigue) and to evaluate the possibilities for reducing the costs of installed blades. The project brings together a new partnership from four different countries: the Danish wind turbine blade manufacturer, LM Glasfiber A/S, the structural integrity section of the German research establishment, DL
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'NR2F6 Blockade as Adoptive Immune Cell Therapy for Metastatic Melanoma' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Melanoma cases and deaths are expected to increase in the coming years, representing a significant burden for the European economy and healthcare system. Metastatic melanoma (MM) is the most serious form of skin cancer and is characterised by uncontrolled metastatic spread of melanocytes to distant sites. Although standard treatments exist, significant clinical challenges remain, resulting in limited response and high MM recurrence rates. As a result of these limited treatment options, the quality of life of MM patients is dramatically compromised. Emerging immunotherapies, such as adoptive cell therapy (ACT), are promising but have significant obstacles, including long manufacturing times, high costs and, most critically, rapid exhaustion of infused cells due to the tumour immune microenvironment (TIME).Research in Gottfried Baier's lab has identified a unique way to effectively stimulate the immune system with an ACT by inhibiting NR2F6, an intrinsic immune checkpoint of T lymphocytes. This is done through our NR2F6 blockade-based adoptive immune cell therapy for metastatic melanoma (NR2F6-AIM) approach, where T cells are engineered for enhanced immune fitness prior to infusion. This greatly sensitises the patient's immune system to currently available immune checkpoint inhibitor therapy (ICT). This approach will permit us to deliver a combinatorial treatment that can overcome TIME immunosuppression, providing curative potential against MM. NR2F6-AIM will block NR2F6 by a non-viral, time-boxed gene silencing through a synthetic small interfering RNA (siRNA) transfection method. This method will allow us to overcome therapeutic manufacturing hurdles through a one-day in-hospital preparation of the ACT. NR2F6-AIM will verify and optimise the technology in relevant in vi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ENHANCING WASTEWATER TREATMENT PROCESSES BY CREATING AN INNOVATIVE TURNKEY SOLUTION FOR MARITIME TRANSPORTATION INDUSTRY' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

World’s population is about 7.7 billion. Every human being produces an average of 1.3 kilograms of organic waste every day. Organic waste causes difficult and costly challenges everywhere, where there are drain pipes. For example, cruise ships experience major problems due to organic waste. It builds up in drain pipes causing foul odors and blockages ruining customer experience, and at worst, causing fatal accidents. ProtectPipe Oy is a microbiotechnology company. Our disruptive solution literally eats fat, oil, grease and other organic waste from the drain pipes leaving drain pipes clean increasing their lifespan and minimizing the risk of blockages or other sewer related problems. Our microbial liquid consists of five different kind of non-pathogenic microbial strains, which are all hand-picked and particularly chosen to eat different organic waste.At the moment we have approximately 1000 customers in six different customer segments. In this project we will focus on a substantial and our most potential customer segment: Maritime Transportation Industry (MTI). MTI consists of 4281 active cruise ships, 52183 merchant and 5793 naval vessels. Our comprehensive solution for a single ship costs approximately €100,000. Thus, the market potential of the whole industry is huge. Wastewater treatment processes in the industry are old-fashioned. Therefore, we see that our solution fulfills the needs of our potential industry customers.At this point, we have already conducted a several pilot projects with different cruise ships and naval vessels and achieved amazing results with our product. Many of the pilot projects have already led to permanent relationships with our customers. However, we still have not been able to create a comprehensive, breakthrough solution for our MTI cus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Long Range Telemetry in Ultra-Shallow Channels' (LOTUS), addressing dissemination and exploitation.

assistant: **Impact**

The main objective is to develop the technology for a long to medium range acoustic communication network capable of operating over distances far larger than the water depth. The network would provide greatly increased capability for monitoring, and acquiring data from, a set of unsupervised sub-sea instruments and long range AUVs, via a ship or a surface buoy providing a radio/satellite link to land. Acoustic communication is the only realistic option for such a network since optics and radio waves are too highly attenuated in sea water. The proposed experimental network would achieve a point-to-point link of up to 10 km using an 8 kHz carrier, with target data rates of up to 4 kbits/s on each link using coherent modulation. Scaling for longer ranges will be considered by modelling. The main technical difficulties arise from the strong, time varying reverberation present in the very shallow channel (causing both fading and intersymbol interference), and from co-channel interference from units transmitting simultaneously. Promising results have been achieved with receivers based on recent signal processing methods that exploit the uncorrelated fading characteristics on all the various signal paths to separate them at the receiver. These innovative multi-access methods, in combination with traditional techniques, will be investigated by using a 3-D array of transducers at the receiver to achieve spatial diversity, with an adaptive combiner optimised for each signal source. The design of the adaptive combiners will be an important part of the investigation in which modern cyclostationary and higher order signal statistics will be exploited. The concept of a network has several other advantages: (a) by using a number of short hops, much longer ranges can be achieved; (b) i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sink-related cleaning practices to prevent transmission of pathogens in healthcare settings', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Each year, millions of infections are acquired in healthcare facilities. The hospital water environment (including sinks, showers and toilets) are now recognised as important environmental drivers of these infections- many of which can be prevented by hygiene and infection control measures, including effective cleaning. However, the most effective methods of cleaning the hospital water enviroment are still not known, so current practices may not prevent infections. Concerningly, recent evidence has emerged suggesting that current practices may inadvertently alter the bacterial population in these environmental reservoirs- potentially causing harm to patients. Furthermore, current practices rely on the widespread use of chemical disinfectants, which have ecological and environmental consequences.  With the support of the Marie Skłodowska Curie Actions programme, SELECTION will develop a novel and environmentally considerate method for hospital sink cleaning. SELECTION will first optimise this method under controlled experimental conditions. A study will then be undertaken in a hospital setting to compare this novel approach with current cleaning practices. To understand the effectiveness of these interventions, we will measure the amount of bacteria present in sinks when cleaned with these different methods, and also use metagenomics and bioinformatics approaches to charecterise how different cleaning interventions change the microbial population within these reservoirs. We will interview healthcare workers involved in the implementation of cleaning interventions in the hospital (including cleaning staff, healthcare engineers and infection prevention and control specialists) to understand their perceptions of the novel intervention and outline the roadmap and barriers to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'GEOGRAPHICAL MEDIATION SYSTEM', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

GEOMED seeks to integrate services for the creation and use of geographical information in town planning, environmental protection and other public sectors. The services will provide access, over wide-area networks, to distributed multimedia geographical databases. A shared workspace" will enable storage and retrieval of geographical planning material, and private citizens will be able to add and retrieve information on the network. Assistance for regulated group activity will include support for well-defined administrative procedures. The project will make geographical data cheaper and more accessible and democratize public policy and planning.The GEOMED system will integrate services for creating, disseminating and using geographical information in the sectors of urban planning, public administration, and environmental protection:  1. The information services will improve the interoperability of proprietary GIS systems, providing efficient and cost-effective access to the multimedia geographical data in heterogeneous, distributed GIS databases, over wide-area networks. This would include services for finding relevant GIS data, converting proprietary GIS data to standard formats for data interchange, as well as ways of controlling remote GIS servers from within compound documents and general purpose electronic mail, conferencing systems, and hypermedia systems, such as the World Wide Web.  2. The documentation services will provide a "shared workspace" for storing and retrieving the documents and messages of geographical planning projects, using standard document formats (SGML, OpenDoc). Ordinary users, including the blind, will be enabled to add and retrieve information to the hyperspace of documents available on the network. Security and privacy concerns will be addr