RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Microbially catalyzed electricity driven bioproduction from CO2 at thecathode in bioelectrochemical systems' (MicrobioElectrosyn).

assistant: **Concept**

The breakthroughs in extracellular electron transfer abilities of several bacteria and other technological advancements during last decade facilitated the development of bioelectrochemical systems (BESs) like microbial fuel cells, which are on the threshold from a lab bench to technological realization for electricity generation. The electricity driven microbial metabolism at cathode has recently opened a new horizon in BES research as it provides very appealing and novel route for the production of valuable fuels and chemicals from CO2 and organics [referred to as microbial electrosynthesis (MES)]. At present, bioproduction via MES exists conceptually or to a limited extent in the laboratory. So far, very few microbial catalysts for these processes have been identified and the impact of electrode materials and operational parameters on microbial colonization at cathodes is not known. Furthermore, there is no developed model of such processes in an engineered environment. The proposed research in MicrobioElectrosyn will tackle these aspects on the example of acetate production by employing several microbiological, electrochemical, molecular biology, chromatography, bioengineering methods and techniques. The accomplishment of proposed objectives with a multidisciplinary approach is expected to advance the MES research with regard to aforementioned challenges for the production of fine chemicals from CO2 and electricity as well as generate scientific and commercial outcome with both environmental and economic benefits for the EU. It represents a Carbon Capture and Consumption approach and is in strong relationship with several national programs worldwide to transform CO2 into new molecules. Overall, it will enable and promote innovative and knowledge-based technologies fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular Logic Machines by Electronic Excitation and Inter- and Intra- Molecular Quantum Dynamics' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

MOLDYNLOGIC is a high risk project exploring the implementation of combinational logic circuits and finite state computing machines based on a single molecule or assemblies of molecules. Our exploratory work, validated by experiments, has shown that it could be possible to achieve programmable machines on a single molecule and also to concatenate the logic operation of two molecules. MOLDYNLOGIC proposes more complex finite state machines, and furthermore, machines which have the ability to perform many cycles. Towards this aim, it gathers a team of European experts in synthesis and supramolecular chemistry, electrochemistry, laser chemistry and theory. The project will demonstrate the construction and assembly of chemical systems with logic and computational functionalities. Tailored organic materials including modular biomolecules and photoactive motors, transition-metal complexes and functional nanoparticles will be synthesized and assembled as supramolecular structures and their logic functions will be examined in solution and on surfaces. We envisage two types of inputs: laser excitation, including shaped pulses and voltage pulses. The logic is implemented by the dynamics of the molecular backbone, which also serves as a very fast link between different logic units of the molecular system. The processing of the information relies on an application of the quantum inter- and intra-molecular dynamics of non-stationary molecular systems, in particular of charge and energy transfer and of conformational changes. Specific studies will be undertaken to establish the structural and dynamical features relevant to logic functions and efficient concatenation. In parallel, we will theoretically investigate non Boolean logic in order to take full advantage of the complexity of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'AGE-RELATED CHANGES IN HEMATOPOIESIS' (ARCH) under Horizon 2020.

assistant: **Objectives**

ARCH is a network of highly qualified experts in experimental hematology created to decipher the causal relationship between the physiological changes in the hematopoietic system during lifespan and the parallel occurrence of specific age-related hematological diseases (pediatric, adult, elderly), with the aim to develop novel targeted therapeutic treatments. ARCH research will integrate the results from complementary model systems (cell lines, mouse models, cells from leukemia patients) and it will deploy a large panel of cutting-edge technologies, such as single cells genomics, epigenomics, genome editing and organoid cultures, in a multi-faceted effort. The ARCH ambitious goal requires scientific and financial resources beyond the capability of a single group. To reach this goal, the ARCH network brings together 15 beneficiaries (12 academic, 2 SMEs and 1 private research institute) and 5 Partner organisations (3 academic, 1 SME and 1 patients’ association). Two European Consortia are present through their italian nodes. ARCH will recruit 15 ESRs that will be all enrolled in PhD programmes. Besides research laboratory work, the ARCH training programme includes scientific, technical and transferable skills courses that will provide ESRs with a solid scientific culture and with awareness of responsible research and innovation issues. This broad portfolio will enable ESRs to become leading academic, clinic or industrial players in the field. The unique combination of scientific excellence, quality of the educational programme and experience in translating basic research into exploitable results will provide ARCH with the real possibility of positively contributing to the enhancement of European competitiveness in the development of innovative, targeted drugs/treatments
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A glimpse into the Arctic future: equipping a unique natural experiment for next-generation ecosystem research' (FutureArctic).

assistant: **Innovation**

Climate change will affect Arctic ecosystems more than any other ecosystem worldwide, with temperature increases expected up to 4-6°C. While this is threatening the integrity and biodiversity of the ecosystems in itself, the larger ecosystem feedbacks triggered by this change are even more worrisome. During millions of years, atmospheric carbon has been stored in the Arctic soils. With warming, the carbon can rapidly escape the soils in the form of CO2 and (even worse) the strong greenhouse agent CH4.Despite decades of research, scientists still struggle to unveil the scale of this carbon exchange, and especially how it will interact with climate change. An overarching question remains: how much carbon will potentially escape the Arctic in the future climate, and how will this affect climate change? FutureArctic embeds this research challenge directly in an inter-sectoral training initiative for early stage researchers, that aims to form “ecosystem-of-things” scientists and engineers at the ForHot site. The FORHOT site in Iceland offers a geothermally controlled soil temperature warming gradient, to study how Arctic ecosystem processes are affected by temperature increases as expected through climate change. FutureArctic aims to pave the way for generalized permanently connected data acquisition systems for key environmental variables and processes. We will initiate a new machine-learning approach to analyse large high-throughput environmental data-streams, through installing a pioneer ""ecosystem-of-things"" at the ForHot site.FutureArctic will thus channel, building on a timely project in the ForHot area, an important evolution to machine-assisted environmental fundamental research. This is achieved through the dedicated training of researchers with profiles at the in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Reconfigurable POEtic Tissue'.

assistant: **Innovation**

The goal of this project is the development of a novel digital electronic circuit, a flexible computational substrate or artificial tissue, capable of integrating the three biological models of self-organization: phylogeny (P), ontogeny (O), and epigenesis (E). This tissue will be the essential substrate for the creation of POE-based machines, capable of evolution, growth, self-repair, self-replication, and learning. The POEtic tissue will be a cellular surface composed of a variable number of elements, or cells. Each cell will contain the entire description (genome) for the whole tissue and will have the ability to communicate with the environment (through sensors and actuators) and with neighboring cells and accordingly executing a function. During the project, the tissue will be validated on different kinds of applications that can benefit from its life-like properties, interacting with and adapting to their own environment. The goal of this project is the development of a novel digital electronic circuit, a flexible computational substrate or artificial tissue, capable of integrating the three biological models of self-organization: phylogeny (P), ontogeny (O), and epigenesis (E). This tissue will be the essential substrate for the creation of POE-based machines, capable of evolution, growth, self-repair, self-replication, and learning. The POEtic tissue will be a cellular surface composed of a variable number of elements, or cells. Each cell will contain the entire description (genome) for the whole tissue and will have the ability to communicate with the environment (through sensors and actuators) and with neighboring cells and accordingly executing a function. During the project, the tissue will be validated on different kinds of applications that can benefit fro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of non-invasive imaging methodology for improving embryo implantation prediction, via hyper-spectral metabolic profiling' (HSMe-ImPredict) targeting Horizon 2020.

assistant: **Abstract**

In vIn vitro fertilization (IVF) is currently widely applied to address the demographic challenge of our society. Unfortunately, only 30% of the IVF transferred embryos implant and develop to term. As IVF procedures have a stressful physical, emotional, and economic impact on families, especially on women, the field is in need of a methodology, capable to reliably assess embryo implantation potential. Metabolism is playing a crucial role in successful embryo development and implantation. Yet, current metabolic measurements are either indirect or invasive and lack clinical translation capacity. In this proposal, we innovate into the development of an optical methodology based on hyper-spectral imaging of native metabolic autofluorescence and subsequent phasor analysis, for measurement and quantification of mouse embryo metabolism in a fast, direct, non-invasive way. The proposed method has unparalleled advantage in discriminating large number of metabolites (at least 6) in low signal-to-noise conditions, allowing non-invasive imaging and providing direct insight to the embryo viability and implantation potential. We will build extensive metabolic profile libraries and correlate them with the respective in vivo/ ex vivo embryo implantation capacity to determine a metabolic fingerprint characteristic for implantation success. We will consolidate the study into a user-friendly software toolbox, capable to predict the implantation success of a previously unseen embryo.We envision that in the future, this new methodology can be translated beyond mouse model, becoming a valuable IVF clinical tool. The strong embryology and translational expertise of the host group and their clinical and tech-transfer partners , together with the advanced data processing expertise of the second
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Research and development of intelligent operation of roll damping tanks on fishing vessels and offshore support vessels' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The existing anti roll systems fitted to fishing and offshore support vessels are tuned for a particular condition of the vessel and in other conditions of the vessel and in other conditions can be a danger to the vessel. Fishing vessels and offshore support vessels have continually changing stability conditions dependent on catch rates and at sea loading (or discharging) of cargo. The proposed system will monitor the condition of the vessels throughout the voyage and adjust itself accordingly to give a safe and stable working platform as required by Annex 1 of Council Directive 93/103/EC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Invisible made Visible:Far-Infrared Spectroscopy in Support of Astrochemistry' (FISSA).

assistant: **Concept**

The interstellar medium (ISM) is filled with highly diluted matter. Chemical processes in the ISM are largely obscured by interstellar dust, prohibiting a detailed view of the chemical evolution of star forming regions. Far-infrared (terahertz; THz) observations of interstellar gas, ice and dust have the potential to penetrate deeply into molecular clouds and reveal the full history of star and planet formation. Accordingly, Herschel Space Telescope, SOFIA and ALMA, present astronomical flagship facilities, promise to open a new era in the THz astronomy. To fully realize this promise it is essential to achieve quantitative experimental THz studies of interstellar dust, ice, and gas. The goal of the outgoing part of this project is to produce laboratory THz spectra of interstellar ice analogues in support of Herschel Space Telescope, SOFIA, ALMA and future facilities. This project will provide the scientific community with an extensive terahertz ice-database, which will allow quantitative studies of the ISM, the possible detection of pre-biotic species and will, therefore, guide future astronomical observations. This part of the project will be carried out within the laboratory group of Prof. Blake in Caltech. The return project will be performed at the FELIX facility (Radboud University Nijmegen, The Netherlands) within Dr. Cuppen (Theoretical Chemistry) and Prof. van der Zande (Molecular and Biophysics) groups and aims at studying in laboratory the molecular mobility in icy layers at the level of individual particles to reveal further details of chemical processes in the solid state in the ISM. Results will be implemented in Molecular Dynamics and Monte Carlo models of Dr. Cuppen, who simulates ice evolution for astronomical relevant timescales, pushing experimental re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'COPD Pathology: Addressing Critical gaps, Early Treatment and Innovative Concepts' under Seventh Framework.

assistant: **Concept**

COPD is the only chronic disease with an increasing mortality and it will constitute the 4th leading cause of death by 2035 world wide. To alleviate the burden of COPD an accurate and easy diagnosis in the early stages of COPD needs to be developed.  Many studies strongly suggest that there is an individual genetic susceptibility to COPD: only 10-15% of all smokers develop COPD. In another study, 53% of subjects had mild and 13.3% severe emphysema. When that genetic susceptibility becomes known, new diagnostics and a better insight into the pathogenesis of COPD will become available. Treatment or prevention come into reach.  Several studies have elucidated a low number of significant genetic differences obtained via the candidate gene approach: a better approach is a genome wide scan. The results of such a genome wide scan will be compared between smokers with and without COPD. This approach has proven itself in e.g. diabetes mellitus.  Data show that diagnosing COPD by only using pulmonary function tests, will only pick up a minority of the patients with emphysema. So, a diagnostic bias is often present, but avoided in the current study: it is the first time that data on CT scans and pulmonary function are combined for an accurate diagnosis.   We will carry out a 300.000 SNP genome wide scan in a 4000 male heavy smokers with and without COPD. The diagnosis of COPD is based on using pulmonary function tests and CT-scanning.  A replication study with the ~3,000 most significant  SNPs will be performed in 5 European replication cohorts to remove false positives findings, study sex influences, population stratification and disease severity.   We will also investigate gene expression in peripheral blood of smokers with and without COPD. The gene expression data will assist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sliding mode control theory - discrete control of uncertain linear continuous-time systems, non linear discrete-time and continuous-time systems' (1994-1998).

assistant: **Concept**

Research objectives and content Sliding-mode control of continuous time-systems with robust continuous-time control techniques has been under investigation for decades world-wide. However, implementation nowadays is in discrete time. A mathematical proof of stability and robustness is especially complicated for discrete-time control . A recent literature study on discrete sliding mode control showed that current developments cannot deal with uncertainties which would be overcome via robust continuous-time control techniques. Work has been conducted by the scholarship applicant during the last weeks on discrete-rime sliding-mode control of uncertain, linear, continuous-time systems. A new control law has been proposed. which ensures robust stability and provides the advantage to abolish one of the main problems of discrete-time sliding-mode control, high frequency chattering. It has proved to be disadvantageous to design discrete-time controllers for continuous-time systems in the discrete-time domain disregarding the sampling process and its major influential factor, the sampling time. The developed technique has now to be applied to sliding-mode-controllers which use output information only or include dynamics as integral control or observer techniques. Case studies will be carried out to show the validity of the theory. As a first step. the simulation of a benzene production plant is under consideration. The second part of this project will be the research in the area of discrete-time control of non-linear systems. Training content (objective, benefit and expected impact) The applicant aims to achieve the PhD of the University or Leicester. He would like to have after that time proper skills in the mathematical analysis of discrete-time controlled uncertain linear or