RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The interactions between taxation and imperfect labour markets' to be submitted under Sixth Framework.

assistant: **Abstract**

The focus of the current project is on the impact of taxation on outcomes when labour markets are imperfect. The aim of this project is twofold. As a first point, we want to determine in a theoretical part the efficiency-equity trade-off and the optimal tax schedules when the distortions in the economy come in through labour market frictions rather than through labour supply responses.And as a second point, we want to determine which setting is empirically most relevant in the European context, i.e. which frictions or labour supply reactions can best explain the elasticity of income with respect to the marginal tax rate. This finally allows us to derive the optimal tax schedules, and the impact of labour market institutions on it. This project thus consist s of four parts.First, we build a theoretical model of optimal labour income taxation that includes imperfect labour markets where frictions create rents and firms commit to wages when posting a vacancy. Second, we use data from the European Community Household Panel for several European countries to estimate the reaction of on-the-job search effort to tax changes.We are also interested to check how labour market institutions affect this elasticity. Third, we look at income dynamics. The wage posting approach predicts that the income changes mainly stem from the job-to-job changes, while the wage bargaining approach predicts that also the income of those who stay in the same job changes.Our data allow us to discriminate between these two models. Finally, we use the empirical findings to calibrate the model derived in the theoretical parts. Simulations of this model then lead to policy recommendations concerning tax reforms and reforms of the labour market institutions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Inas/algasb heterostructures for high speed electronic devices', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

InAs/AlGaSb heterostructures have favourable properties for high speed devices with low power consumption which promise to provide superior performance compared to devices based on other material systems. Already field effect transistors and other electronic devices using InAs/AlGaSb heterostructures have been realised and it has been demonstrated that the relevant device parameters for high speed applications reflect the excellent intrinsic properties of this semiconductor. However, field effect transistors realised so far do still not make use of all advantages of InAs/AlGaSb. The reason can be seen in the insufficiently developed technology of fabrication and processing of devices with this new material system. The specific project is to fabricate and study field effect transistors that make use of the latest developments in material research on InAs/AlGaSb, thereby bridging the areas of fundamental physics and device applications. Following on the demonstration of state-of-the-art mobility in this material system in our group heterostructures that show the combination of highest mobility and carrier concentration are processed using photo- and electron beam lithography. The fabricated devices are examined with electrical and spectroscopic characterisation techniques. The experimental work is completed with modelling and simulation of the devices. The correlation between fabrication techniques and device performance is studied in order to find conditions for an optimal exploitation of the properties of InAs/AlGaSb for high speed field effect transistors with low power consumption.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'ProNet - Prosthetic Transgene Networks for the Treatment of Metabolic Disorders' to be submitted under Seventh Framework.

assistant: **Abstract**

Since living memory, the basic treatment strategies for the therapy of human diseases has not much changed conceptually. Although the molecular understanding of metabolic disorders continues to progress significantly the therapeutic strategy is still based on specific, often heterologous compounds which interfere with critical disease targets, trigger a metabolic bypass reaction or complement a molecular deficiency. As systems biology is revealing gene-function correlations and metabolic network dynamics at great pace and synthetic biology enables bottom-up de-novo design of genetic devices with predictable behaviour, time has now come to develop novel treatment strategies. Prosthetic genetic networks are expected to play a central part of such future treatment strategies. Prosthetic networks are synthetic sensor/effector devices or molecular prostheses which, upon integration into cells and functional connection to their metabolism, monitor disease-relevant metabolites, process off-level concentrations and coordinate adjusted diagnostic, preventive or therapeutic responses in a seamless, automatic and self-sufficient manner. Using a synthetic biology approach and capitalizing on our pioneering prosthetic network designed to control urate homeostasis and treat the tumour lysis syndrome as well as gouty arthritis, ProNet is a highly integrated, multiparallel and interdisciplinary effort to provide a series of prosthetic sensor/effector circuits for precise trigger-control of therapeutic transgenes. ProNet will focus on providing novel treatment opportunities for diabetes and obesity, two core pathologies of the metabolic syndrome, which is on its way to become the top epidemic of the 21st century. ProNet may provide new opportunities for the treatment strategies of the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Covering mappings and their applications in functional equations, difference equations and optimization'.

assistant: **Objectives**

There will be considered covering mappings and their applications. The properties of covering mappings in generalized metric spaces will be studied. Moreover, sufficient solvability conditions for inclusions defined by conditionally covering multi-valued mappings in metric spaces will be obtained. This results will be applied to the following problems. For difference equations there will be studied such issues as solvability,  equilibrium existence and stability. In addition, there will be studiedseveral types of functional equations. This part of research will be based on the result obtained for covering mappings in generalized metric spaces. Finally, there will be studied questions of global solvability for control systems and necessary optimality conditions for control systems defined by Volterra equations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'On a Nuclear Waste Deep Repository Simulator'.

assistant: **Objectives**

Nuclear waste is generated during the operation and maintenance of nuclear power plants. The waste is first transferred to an interim storage, where it remains for tens of years, till radioactivity and heat generation of the spent fuel is reduced to a level that allows its final disposal. It is generally accepted that the final waste will be disposed of in a deep geological repository. However, not a single country worldwide has an operational underground repository. In the design process of these repositories, simulation tools capable to model their long term behavior (hundreds of years) are required. However, such simulations are extremely challenging, due to the complicated nature of the physical phenomena of multiscale and multiphysics nature. Current numerical tools being used by some of the most advanced deep repository projects use CODE_BRIGHT (developed at UPC-CIMNE), a very rich code in terms of modelling capabilities, which benefits from 20 years of intensive validation against in-situ experiments. However, CODE_BRIGHT is a serial structured FORTRAN 90 code with very limited capabilities in terms of parallel performance. As a result, actual analyses of prototypical deep repositories require strong and not validated simplification assumptions, in order to reduce by some orders of magnitude the computational cost of the target simulations. In this project, we want to change the situation by developing extremely scalable simulation software for nuclear waste management in repositories.  The strategy is to port CODE_BRIGHT modelling capabilities to FEMPAR, the extremely scalable scientific computing code that resulted from the Starting Grant COMFUS. The result of this work will be a new software that (1) produces the same results as CODE_BRIGHT for a wide set of b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'MATHEmatics of Multi-level Anticipatory Complex Systems' (MATHEMACS).

assistant: **Concept**

The MATHEMACS project aims to develop a mathematical theory of complex multi-level systems and their dynamics. In addition to considering systems with respect to a given level structure, as is natural in certain applications or dictated by available data, the project has the unique goal of identifying additional meaningful levels for understanding multi-level systems. This is done through a general formulation based on the mathematical tools of information and dynamical systems theories.To ensure that the theoretical framework is at the same time practically applicable, three key application areas are represented within the project, namely neurobiology, human communication, and economics. These areas not only provide us with some of the best-known epitomes of complex multi-level systems, but also constitute a challenging test bed for validating the generality of the theory since they span a vast range of spatial and temporal scales.Furthermore, they have an important common aspect; namely, their complexity and self-organizational character is partly due to the anticipatory and predictive actions of their constituent units. The MATHEMACS project contends that the concepts of anticipation and prediction are particularly relevant for multi-level systems since they often involve different levels. Thus, as a further unique feature, the project includes the mathematical representation and modeling of anticipation in its agenda for understanding complex multi-level systems.For validating the theory on large heterogeneous data sets, the project has a specific component with exclusive access to a wide range of data from human movement patterns to complex urban environments.In this way, MATHEMACS provides a complete and well-rounded approach to lay the foundations of a mathematic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'From engineering to evolution of synthetic cells with RNA origami' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Can we construct a cell from non-living matter? In search for answers, bottom-up synthetic biology has successfully encapsulated functional sets of biomolecules inside lipid vesicles, yet a “living” synthetic cell remains unattained. ENSYNC aims for a prototype of a synthetic cell that encompasses a fundamental characteristic of life, namely evolution. My past work shows that DNA origami can achieve custom-engineered synthetic cellular parts, but the mere encapsulation of preformed parts conflicts with the vision of a self-replicating and evolving synthetic cell. I here propose to produce and to replicate functional RNA origami structures inside of lipid vesicles (GUVs) by co-transcriptional folding from a DNA template. First, I will genetically encode an RNA nanopore and RNA origami structure which induces GUV division. The DNA template (“genotype”) will determine the GUVs’ permeability and their division rate (“phenotype”). This genotype-phenotype mapping is the basis for directed evolution of the rationally engineered RNA origami structures in the second step. In particular, I will aim for efficient GUV division in repeated cycles of genetic diversification and selection. In the third step, I will implement multiple growth and division cycles to enable continuous directed evolution. This will be achieved by system-level integration and laboratory automation of the directed evolution pipeline to iteratively reduce researcher intervention. Depending on externally applied selection pressures, continuous evolution will inevitably lead to the dominance of highly proliferating synthetic cells in mixed populations. ENSYNC provides fundamental insights into evolutionary processes as well as applicable RNA origami-based tools for nanopore sensing and as genetically encoded bi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Closing the gap: studying non-obvious ligand induced degradation events' (MapInDegraders) targeting Horizon 2020.

assistant: **Abstract**

Inhibitor-induced target destabilisation has been reported sporadically in recent years. Importantly, despite never actually having been put in place on purpose – or by design – these effects often play a significant role towards their therapeutic effect. To date, no systematic approach to map or quantify these serendipitous destabilising events has, however, been performed, representing a huge underexplored space with large translational potential. I here propose to study ligand-induced destabilisation by utilising the plethora of available protein kinase inhibitors to systematically map their kinase degrading abilities. First, an innovative in vivo assay will be developed to monitor kinase stability at scale. Next a protein kinase inhibitor library will be screened and inhibitor-destabilised kinase pairs will be identified using automated high-throughput microscopy, coupled to fluorescent activated cell sorting and next generation sequencing. Pharmacokinetic mode-of-action binning and machine-learning based computational data mining will chart the map of ligand-induced destabilisation and delineate crucial protein, chemical and/or biophysical properties. Finally, based on the principal mode-of-action identification, measured effect size and translational potential, in-depth mechanism of action studies will be conducted for one selected inhibitor-kinase pair. To that end, a multi-omics approach consisting of genome-wide CRISPR screens and orthogonal genomics and proteomics strategies will be conducted.  The project will delineate the underlying concepts of ligand-induced destabilisation using protein kinase inhibitors as a chemically well explored compound space and thus open new avenues to tap into the translationally intriguing area of designing targeted protein degr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Cosmology with voids and superclusters: combining theory, simulation and observation'.

assistant: **Concept**

The aim of this cosmology proposal is to study the contents, history and evolution of our Universe, using the distribution of matter on large scales. I propose to study new methods to identify and catalogue rare voids and superclusters in the large-scale structure of the Universe and to study their statistical, morphological and dynamical properties. I will use these studies to propose new observables and new techniques of data analysis based on these structures, and to use this knowledge to test theories of gravitation, dark energy and the initial conditions of the early Universe. Interest in cosmic voids in particular has increased greatly in recent years, as they have been suggested as extremely competitive probes of cosmology, according to some estimates significantly out-performing other methods. Yet there remain unsolved theoretical difficulties in the modelling of voids and even a lack of consensus on how to identify them and how to relate theory and observation. Even less is currently known about superclusters. These are among the important issues I propose to address. My proposal consists in roughly equal parts of: analysis of the latest high-quality survey data which will available from the Sloan Digital Sky Survey (SDSS) and the Dark Energy Survey (DES); analysis of the state-of-the-art Jubilee ISW and weak lensing simulations run on the Juropa supercomputer in Germany; and theoretical work to combine insights from data and simulation to improve our understanding of cosmology. The proposed work is to be carried out in collaboration with leading experts in the respective fields from across the European Community, in particular in the United Kingdom, Spain and Germany.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A coordinated approach twards development of a scientific basis for management of wild Atlantic salmon in the North-East Atlantic' (SALMODEL).

assistant: **Concept**

OBJECTIVES AND EXPECTED ACHIEVEMENTSThe problems to be addressed Salmon display great plasticity in the age at which they migrate to sea, the age at which they mature, and the occurrence of repeat spawning. This may lead to significant overlap of generations. Additionally, because of their diadromous life cycle and varied oceanic migration behaviour, physical/temporal overlap occurs in oceanic and home-water fisheries, many of which exploit salmon from more than one river stock.While biological information can be gathered on fish numbers in rivers with monitoring programmes, and in coastal and high seas fisheries, it is very difficult at present to relate this to production at the population level and to advise managers on how many fish can be safely caught nationally, regionally, or locally, while still fulfilling long-term management goals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Emergence of collective behaviour across mycorrhizal fungal networks' (COMYCO).

assistant: **Innovation**

Underground, mycorrhizal fungi build complex networks to engage in symbiotic nutrient transfer with plants, exchanging soil nutrients (phosphorus, nitrogen) for plant-derived carbon. These plant-fungal partnerships play a critical role in carbon cycling, mineral uptake, and ecosystem resilience. Recent research from the host group and others has found that mycorrhizal fungi exhibit complex behaviours that regulate nutrient exchange with their plant hosts. Yet, despite their ecological importance, the cellular dynamics and the signals that enable these sophisticated behaviours across mycelial networks lacking central organisation remain unknown.Through a new biophysical approach, COMYCO seeks to unravel how mycorrhizal fungi mediate their behaviour to engage in symbiotic trade. I will develop micromanipulation techniques to deliver (1) localised perturbations at the cellular level and (2) network-scale stimuli that alter the growth environment. These stimuli will perturb nutrient transport machinery, metabolism and host availability to trigger behavioural responses. Leveraging robotic imaging technologies from the host lab, I will quantify responses from individual hyphae (microns) to entire networks (centimetres). This will enable unprecedented stimulus-response experimental paradigms that quantify mycorrhizal behaviour in real time. To explore the exact signals that mediate these responses, I build on my expertise in microfabricated glass probe techniques and the host lab’s strength in fluorescence imaging, quantifying (1) electric membrane potential, (2) intracellular calcium concentration, and (3) turgor pressure in fungal signalling processes.Integrating these cross-scale experiments through biophysical analyses, my research will establish a new mechanistic understa