RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ampleness and very ampleness of vector bundles on rational surfaces', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content My field of research is mathematics, and the proposed project is part of the branch of mathematics called algebraic geometry. Specifically, the project is about vector bundles on rational surfaces where a famous conjecture by the Japanese mathematician Nagata long has attracted much attention. A new method, invented by the Israeli mathematician Ziv Ran while working at Universiti de Nice, produces significant new results in the direction of Nagatas conjecture. While studying with Prof. Robert Lazarsfeld at University of California, Los Angeles (UCLA), I learned about the problem and became interested in the new development. An invitation from Prof. Andri Hirschowitz at Universiti de Nice made it possible to study the problem at first hand, while working with some of the foremost algebraic geometers in the world. My project is to generalize and deepen the new results and ideas of Ran and to make the results useful and accessible to a wide audience by implementing the method in a computer programme. I will attack new cases of Nagatas conjecture, and I aim to understand and explain the wide variety of approaches that has been made to the problem, thereby obtaining new insight in the subject. Training content (objective, benefit and expected impact) Working with the leading experts in the field on this important problem will be of immense impact on my research, my Ph.D. thesis, and greatly benefit further research.  Links with industry / industrial relevance (22) The implementation of these new methods on computer might prove of commercial interest, and be useful for a wide audience.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Biochemical and CryoEM studies of spliceosome activation.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Pre-mRNA splicing is a fundamental maturation step of eukaryotic mRNAs that consists of the removal of introns and the concomitant ligation of exons by two successive transesterification reactions. This complex biological process is catalyzed by the spliceosome, a gigantic ribonucleoprotein particle that assembles de novo on each intron and uses a single RNA-based active site to perform both reactions. The spliceosome is composed of five snRNPs (U1, U2, U4, U5, U6) that are recruited to pre-mRNAs in a stepwise manner. When a pre-catalytic spliceosome, consisting of all five snRNPs, is formed on a pre-mRNA it has no pre-existing active site and undergoes extensive compositional and conformational changes to become “catalytically competent”. During this transition, two snRNPs (U1 and U4) are lost and several new factors are recruited, ensuring the formation and stabilization of the active site as well as the correct positioning of the pre-mRNA’s reactive groups in the catalytic centre. Thanks to recent technological advances in Electron Microscopy (EM), a series of cryoEM structures of fully assembled “active” spliceosomes at atomic resolution have been solved in the host group and elsewhere, in the past two years. These structures, which have created much excitement in the RNA community, visualize the spliceosome during each step of the catalytic cycle and allow a mechanistic understanding of catalysis. However, due to the scarcity of high-resolution information on earlier complexes, many questions remain regarding spliceosome activation.My project aims at filling a gap in our understanding of pre-mRNA splicing by unraveling the molecular details of spliceosome activation. To that end, I will use a combination of biochemical characterization and cryoEM to study yeast spl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Using trust and reputation to Improve security in virtual societies'.

assistant: **Innovation**

This proposal has three main objectives:1. Improve the reliability and security in e-Commerce environments. Trust and reputation systems are currently being implemented as an alternative or as a complement to sanctions for regulating transactions and discouraging cheaters in e-Commerce environments. However, the efficiency of reputation systems currently implemented is not as good as it would be desirable. If we want to undertake current problems of virtual societies we need theoretically more sophisticated reputation systems. A cognitive model of trust and reputation, fully operative and comprising its transmission mechanisms, is needed. Using as the basis for our approach the work and experience of the host institution in cognitive systems and the experience on trust and reputation models and multi-context systems of the applicant we will build a fully operative cognitive trust and reputation model that can be used in current electronic communities.2. Provide a common metrics to compare computational trust and reputation models. On the contrary that in other areas of computer science, in the area of trust and reputation models it does not exist a common test-bed to compare trust and reputation models. We want to build a test-bed that:(i) gives a common experimental environment where to compare all computational trust and reputation models under the same conditions and(ii) allows to clearly determine the strengths and weaknesses of each model.3. Increase people\'s confidence in multi-agent systems technology. Improving the reliability and security of e-Commerce environments by means of better trust and reputation models we are contributing to increase the users confidence level on multi-agent systems. The proposal address directly points 2.3.1.5 and 2.3.2.4 of the 1ST
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'STRENGTHENING THE SFAX UNIVERSITY EXPERTISE FOR DIAGNOSIS AND MANAGEMENT OF EPILEPTIC ENCEPHALOPATHIES', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Epileptic encephalopathies (EE) are heterogenous epilepsy syndromes associated with severe cognitive disturbance. EE vary in their onset age, seizure types, electroencephalographic patterns and etiologies. New molecular technologies increased the genetic diagnosis rate. Inline with EU orientations and Twinning requirements, the SEED project will provide Sfax University (SU), with capacity building in excellence and innovation for earlier clinical and genetic diagnosis of EE, thanks to collaboration with AMU and UA, two internationally leading organisations for the diagnosis of EE.  Early clinical and genetic diagnosis allows early management, improves prognosis and reduces health costs. The SEED project will: 1) strengthen the medical and technological capacity towards innovative technologies of SU in the field of EE 2) allow access to scientific excellence at international level for members of the SU which will lead  ultimately to a better  integration into international networks in MENA and EU regions. The successful implementation of this strategy will rely on specific actions including: 1)enhancement of the existing and the creation of innovative scientific and technical collaborations through short-term staff exchanges and short-term on-site training activities; 2)training young researchers from SU to become trainers; 3)creating an experts’network for EE management centred at SU; 4) increasing awareness among the patient’s families through targeted dissemination and communication activities and 5) developing a strategy to sustain network activity beyond the project deadline.  Through the completion of these activities, and with the support of AMU and UA, SU will be able to significantly reduce networking gaps, to increase its ability to compete for international re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of a DNA vaccine for visceral leishmaniasis' (LEISHDNAVAX).

assistant: **Innovation**

This project will focus on the preclinical development of a DNA vaccine for human visceral leishmaniasis. The project is based upon the DNA vaccine technology and immunomodulators developed at Mologen AG (Berlin, Germany), which are in clinical development for cancer and 3-5 known antigens that already have demonstrated profiles of protection in animal models of leishmaniasis. Antigens will be selected on the basis of preset criteria to assure protection in high proportion of target populations and against many different species of Leishmania. In vitro and in vivo models will be used to evaluate the prophylactic and therapeutic efficacy of the DNA vehicle with selected antigens alone and in combination with and without immunomodulator. Full toxicology studies will be performed on selected candidate vaccines. Training in preclinical development and clinical trials (ICH-GCP) are an important part of the proposal. Sites will be selected and ready to initiate clinical trials at the end of this project (3 years).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sensitivity of tree-growth to climate change and growth modelling from past to future' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of the project is to assess the sensitivity of tree-growth to climate change in mountain and Mediterranean forests both in its past variability and in the future, as predicted by climate models for a CO2 doubling scenario. This will provide a basis for assessing environmental and socio-economic impacts of different tree-growth potentials and for allowing the development of strategies for sustainability in future forest management. Around the structure of a data base, the project will build a network of tree-ring and meteorological data covering, with the highest possible density, three target areas representative of mountain and western Mediterranean forests. All available ring-width chronologies which are presently sparse at the different partners will be at first actualised and introduced in the data base. Besides, a large effort of sampling will be done to strengthen the chronology network in order to obtain a spatial grid dense enough to master the spatial variability of climate-environment complex and representative of the main conifer species. Moreover, to approach at best biomass production the intraannual variations in wood anatomy will be taken into account using densitometric analysis. In order to obtain a global representation of coniferous forest diversity, core sampling will be mapped at the forest level using remote sensing and GIS techniques. All tree ring chronologies (ring-width or densitometric values) will be treated in the same way. Statistical models of tree ring to climate relationships will be established using improved methods and new statistical developments. The first objective will be to analyse the spatiotemporal patterns of tree growth at present and in the past in order to isolate at best the climatic signal in tree-ring chronologie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Small turbomachinery research' (STR).

assistant: **Innovation**

Use of small turbomachine (air processing, turbochargers, and small gas turbines) has been hindered by poor performance. Since highly efficient turbomachines have been demonstrated at larger powers, it can only be surmised that the conventional practice of scaling down designs for small turbomachine is inadequate. It is proposed to improve small turbomachine design, manufacture, and performance by a generic research project, STR. The aim is to develop methodologies for the design of small turbomachine components suitable for a wide range of applications. This highly innovative project also includes a proof of concept phase. The target achievements at improvements of component efficiencies (4 points for the compressor and 3 points for the turbine), a reduction in fuel consumption and CO2 emissions by 10% and a 12% reduction in engine size for 50 kw power output compared to existing technology.The main results and conclusions from the STR are as follows:All six components: axial: (two sets for baseline and two sets for advanced); Radial Baseline (compressor and turbine) and Radial Advanced (compressor and turbine); were designed;- All components were manufactured;- Axial turbines were manufactured by machining from solid as well as by casting. Methodologies for advanced casting were developed and put-in-use at PBS;- Both sets of axial turbines were tested on an actual gas turbine and show improvements beyond expectations;- A radial test rig was developed capable of testing un-matched radial machines with substantial axial thrust;- Radial baseline compressor was fully instrumented and tested. The data corroborated inlet/outlet data previously generated by LTS. The date also helped to understand the detail characteristics of the compressor that were previously only assumed;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Global Gravity-based Groundwater Product' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Groundwater is one of the most important freshwater resources for mankind and for ecosystems. Assessing groundwater resources and developing sustainable water management plans based on this resource is a major field of activity for science, water authorities and consultancies worldwide. Due to its fundamental role in the Earth’s water and energy cycles, groundwater has been declared as an Essential Climate Variable (ECV) by GCOS, the Global Climate Observing System. The Copernicus Services, however, do not yet deliver data on this fundamental resource, nor is there any other data source worldwide that operationally provides information on changing groundwater resources in a consistent way, observation-based, and with global coverage. This gap will be closed by G3P, the Global Gravity-based Groundwater Product. The G3P consortium combines key expertise from science and industry across Europe that optimally allows to (1) capitalize from the unique capability of GRACE and GRACE-FO satellite gravimetry as the only remote sensing technology to monitor subsurface mass variations and thus groundwater storage change for large areas, (2) incorporate and advance a wealth of products on storage compartments of the water cycle that are part of the Copernicus portfolio, and (3) disseminate unprecedented information on changing groundwater storage to the global and European user communities, including a European use case as a demonstrator for industry potential in the water sector. In combination, the G3P development is a novel and cross-cutting extension of the Copernicus portfolio towards essential information on the changing state of water resources at European and global scales. G3P is timely given the recent launch of GRACE-FO that opens up the chance for gravity-based time seri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Spectroscopical analysis and dynamics of molecules of atmospherical interest' (1994-1998).

assistant: **Concept**

Research objectives and content The proposed work consists in theoretical spectroscopical studies for CO2 and 03. Different objectives are proposed for these molecules:-In the case of CO2, I expect to improve the existing potential energy and dipole moment functions of Wattson and Rothman, in order to be valid at high temperature (high excitation in J). I expect these functions to be useful for the prediction of the IR spectrum of CO2 at higher temperature. The adjustment will be done by a Direct Numerizal Diagonalization (DND) of the rovibrational molecular hamiltonian in curvilinear (hyperpherical) coordinates. A comparative analysis will be made of a normal coordinate versus a curvilinear coordinate description.- In the case of ozone, I will develop a semiclassical method for the analysis of the photodissociation products of ozone in the Hartley band at high temperature. The calculation will take into account the vibrational and rotational movements of the molecule as well as different excited electronic states. This fact makes the problem too large to be treated in a quantum calculation. Consequently, a semiclassical approach has to be applied in which the rotation of the molecule will be studied classically. Training content (objective, benefit and expected impact) An important benefit for the research group at the University of Murcia is the implementation of the techniques I have used during my postdoctoral formation. These techniques are, mainly, the quantum treatment of rotation of triatomic systems. the use of wavepacket propagation for the act quantum resolution of the time dependent Schrodinger equation, and the use of the Lanczos algorithm for the obtention of the eigenvalues of a system. The expected impact will consist on simulation of the Venus greenhous
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'AWARENESS, ALERT AND RESPONSE FOR CB THREATS IN FOOD DEFENCE' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The food chain is a sector that is vulnerable particularly to being jeopardised both by accidental events of contamination and intentional threat attacks. Since these incidents in most cases have cross-border impacts, effective collaboration among a wide range of international stakeholders is required to prevent where possible, or otherwise cope with these challenges. Unfortunately, at the European level, efficient tools for the identification and analysis, response and communication, and appropriate mitigation of, in particular,  foodborne chemical (C) and biological (B) threats are either limited, or completely absent.The vision of the REACTION project is to increase Europe’s resilience towards foodborne chemical and biological (CB) threats. While in the food safety and food security arena, a significant number of successful international projects and initiatives are already underway, we believe that the food defence sector urgently requires additional attention. Our overall goal is to strengthen Europe’s food defence capability to respond to intentional malicious attacks, through (a) the development of a data-driven monitoring tool for food defence, (b) the development a cost-efficient  and streamlined CB threat identification pipeline, (c) the development of AI-supported food defence management tool, (d) the creation of a European-led International Food Defence Expert Forum, and (e) the design of an information awareness raising campaign for CB threats. REACTION is driven by an experienced consortium of 14 leading European Institutes, Universities (including SSH experts), national food safety and defence authorities, agri-food chain representatives, as well as technology providers, who will cooperate with an International Advisory Board of world-class actors from th