RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Emergence of Cognitive Grasping through Emulation, Introspection, and Surprise' (GRASP) under Seventh Framework.

assistant: **Objectives**

Compared to humans or primates, the ability of contemporary robotic hands is suprisingly limited, they can grasp only few objects in constricted poses with limited grasping postures and position. The aim of GRASP is the design of a cognitive system capable of performing tasks in open-ended environments, dealing with uncertainty and novel situations. We have decided to study the problem of object manipulation and grasping, by providing theoretical and measurable basis for system design that are valid in both human and artificial systems. We believe that this is of utmost importance for the design of artificial cognitive systems that are to be deployed in real environments and interact with humans and other artificial agents. Such systems need the ability to exploit the innate knowledge and self-understanding to gradually develop cognitive capabilities. To demonstrate the feasibility of our approach, we will instantiate, implement and evaluate our theories on robot systems with different emobodiments and levels of complexity. These systems will operate in real-world scenarios, with and without human intervention and tutoring.<br/><br/>GRASP will develop means for robotic systems to reason about graspable targets, to explore and investigate their physical properties and finally to make artificial hands grasp any object. We will use theoretical, computational and experimental studies to model skilled sensorimotor behavior based on known principles governing grasping and manipulation tasks performed by humans. Therefore, GRASP sets out to integrate a large body of findings from disciplines such as neuroscience, cognitive science, robotics, multi-modal perception and machine learning to achieve a core capability: Grasping any object by building up relations between task setti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Network for EXchange and PRototype Evaluation of photonicS componentS and Optical systems' (Nexpresso).

assistant: **Concept**

NEXPRESSO creates and implements a network for evaluation by researchers of prototype photonics components and systems manufactured by SMEs, at no net cost to either the university or the SME.  As a result, students are trained on the next generation of emerging technologies and products as identified by European industries. This training orients students toward advanced technology jobs in Europe, thus helping to develop a highly educated and productive workforce in Europe.SMEs that participate in the NEXPRESSO programme have a new and valuable resource for implementing research and development that is precisely focussed on the products and on the issues that are most relevant to that company's continued growth and success.NEXPRESSO greatly enhances professional mobility, particularly for students and researchers originating in new member countries.NEXPRESSO builds European leadership and competitiveness for SMEs by shortening time-to-market for components addressing new applications, and contributes to broader take-up of advanced photonic technologies by implementing key R&D evaluations that help to enable a prototype to become a product.NEXPRESSO goes beyond the State-of-the-Art created by the ACCORD-programme, which has been a unique project in its kind.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quantum Optics in Wavelength Scale Structures' under Seventh Framework.

assistant: **Concept**

In this project I will investigate the interaction between quantum light and matter in optical structures that are at or below the wavelength scale. Such devices could provide unprecedented performance in the storage of data, the switching of light and the generation of light of tailored properties. I will address this topic through the study of 2-level systems (quantum dots, N-V centres, atoms), and non-linear materials (Ç(2) ,Ç(3) ) in various nanoscale dielectric and conducting structures. This will include:  quasi 1D systems such as pillar microcavities, " 2D systems such as microstructured fibres and suspended waveguide photonic bandgap cavities " 3D systems such as single particle assembled 3D nano-cavities I will design suitable systems using the wide suite of electromagnetic modelling softwares available in my group. This will also involve the inclusion of the allowed modes and their interaction with single two-level quantum systems and non-linear materials."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Synergistic effects of DISpersant, oil and HYpoxia in a teleost fish: Investigating the impact of oil contamination in hypoxic areas and the use of dispersant as a response technique' to be submitted under Horizon 2020.

assistant: **Abstract**

Coastal marine ecosystems are of high socio-economic and ecological importance. However, these ecosystems are under anthropogenic pressures. Among these anthropogenic pressures, two major growing threats are represented by hypoxia (due to eutrophication) and oil pollution. These 2 major threats are particularly presents and coexist in European marine coastal ecosystems. However, scarce studies have investigated the biological impacts of their interaction. Consequently, this project intends to evaluate the potential biological effects caused by oil pollution in hypoxic situations. Additionally, this project will consider dispersant use as a response technique for oil released in these hypoxic areas.Practically, the research actions will estimate the synergistic biological effects of dispersant, oil and hypoxia on a teleost fish species of ecological and economic importance for Europe: the sea bass Dicentrarchus labrax. The approach will firstly evaluate the hydrocarbons contamination induced by the interaction of stressors (Work Package 1). Then, biological effects will be evaluated, at the sub-individual level, by assessing sensitive indicators related to oxidative stress (Work Package 2). Finally, indicators of ecological significance, related to fish behavior, locomotion and metabolism, will be assessed at the organismal level (Work Package 3). The complementarity between the fellow and the supervisors’ profiles and the environment provided by the host and partner organizations insure the achievement of this timely and innovative project as well as the dissemination and exploitation of the expected results. These outputs will permit to inform decision makers on the ecological and environmental issues of oil spill in hypoxic areas and to advise oil spill responders on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Pathogenesis of aids kaposi's sarcoma: biological, clinical and therapeutic aspects', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

To synergize European research capabilities in the field of AIDS associated Kaposi's sarcoma (KS) pathogenesis, particularly with regard to the importance of HIV-Tat and other angiogenic factors, chorionic gonadotropin hormone (hCG) as a possible regressive factor, the role of the newly discovered KS herpes virus (KSHV/HHV-8) and possible development of antiviral therapy as well as the use of animal models.BACKGROUND AND OBJECTIVES:Kaposi's sarcoma (KS), previously regarded as a rare, indolent, usually cutaneous tumor-like lesion, has become a serious public health problem through its frequent association with AIDS in all areas of the pandemic. Recent studies on the development of KS have suggested a role for various pathogenic factors including infection with a novel herpes virus (HHV-8), a deregulated cytokine-growth factor network, HIV associated angiogenic factor(s) (Tat) and immune deficiency, hormonal influence and possibly genetic aberrations. Also the apparently partly tumor-like, partly reactive KS features reflect the complexity and still enigmatic biological nature of this lesion. The proposed research concentration addresses to questions of the importance of various factors suggested from recent studies.The different tasks to be investigated in this proposal will cover the following objectives/aspects:A) HIV-1 Tat protein as an angiogenic factor in the development of AIDS Kaposi's sarcoma (AKS);B) Animal models of angiogenesis and Kaposi's sarcoma;C) Chorionic gonadotropin hormone (hCG) as a repressive factor in KS development;D) Development of an in vitro model system to study the pathogenic role of HHV-8 in Kaposi's sarcoma;E) In vitro characterization of HHV-8 infected KS cells, their angiogenic and tumorigenic properties and the possible activation of HH
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Cholesterol metabolism as a driver of prostate cancer aggressiveness'.

assistant: **Objectives**

According to the WHO, prostate cancer (PCa) is the most common cancer in men in the European Union (EU). The currentview of cellular transformation and cancer progression supports the notion that cancer cells must undergo a metabolicreprogramming in order to survive in a hostile environment. Tumors are not homogeneous entities, and most cancers retaina differential fraction of cells with increased self-renewal capability (cancer stem or initiating cells), that accounts forrecurrence and resistance to therapy. While we know more about the metabolism of tumor cells and its implication in cancer,our knowledge about the metabolism of cancer-initiating cells remains insufficient.Obesity is associated with increased risk of prostate cancer metastasis and death. On other side, statins treatment reducesthe risk of PCa, indicating that cholesterol might have a role in the onset of the disease. Overweight and obesity rates in EUaffect 50 and 20% of the population respectively. Therefore, it is critical to define the role of environmental factors such asnutrition and “lifestyle” for cancer prevention.Preliminary studies in our lab indicate that cancer initiating cells are highly enriched in cholesterol synthesis genes and theirsphere formation capacity is dependent on cholesterol synthesis. We hypothesize that an active cholesterol metabolism isessential for prostate cancer-initiating cell function, and that the use of cholesterol synthesis inhibitors might target this subpopulation of aggressive cancer cells.I will use a combined transcriptomic and metabolomic approach to define the alterations of cholesterol metabolism. I willstudy the mechanisms by which cholesterol metabolism regulates CIC function. I will study the feasibility of therapeutictargeting of cholesterol metabolism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Icephobic Coatings - Development of test methods' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Icephobic coatings are being investigated as functional coatings for laminar flow.  The coatings are intended to support the wing ice protection systems by reducing the formation or adhesion of ice and consequently reducing the energy requirements of the system.  Currently, the most comprehensive method for measuring and understanding the icephobic nature of a coating is by performing icing wind tunnel tests.  These tests require large dedicated wind tunnel facilities and would be too costly and impractical for production batch quality control and release testing purposes.  For this reason a significant part of the research is dedicated to the development of suitable ‘bench top’ test methods that will allow accurate measurement of the icephobic nature of a coating, providing an indication of the long term icing performance of the tested surface.GKN intends to achieve this goal by determining the key contributing attributes to icephobicity of a surface and generating a predictive model, where predictions of performance can be derived from results of readily-available laboratory analytical techniques.  This has not been achieved in entirety before and so to mitigate risk GKN will also attempt to develop in tandem a bench top ice adhesion test method which provides the same order of results as would be observed in an icing wind tunnel.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of a synthetic diversification platform for targeted EVOLUTION of ENZYMES supporting a sustainable bioeconomy – EvoZyme' under Horizon Europe.

assistant: **Concept**

The ongoing climate change requires immediate actions to reduce the CO2 concentration in the atmosphere. One such action is the transition from a fossil-based to a bio-based economy that builds on CO2-derived one-carbon (C1) feedstocks like formate. To this end, synthetic C1 assimilation routes are being engineered into biotechnological relevant microbes.  Among them, the reductive glycine pathway (rGlyP) bears enormous potential for biotechnological applications as it is short, energy efficient, and easy to engineer. So far, optimization of growth on formate via the rGlyP was achieved by adaptive laboratory evolution, a time-consuming process that leads to incorporation of undesired mutations and does not allow targeted pathway optimization (debottlenecking).In EvoZyme, I aim to develop a Synthetic Biology platform for targeted evolution of pathway enzymes. This platform consists of specialized Escherichia coli strains that are equipped with state-of-the-art diversification machineries allowing tunable hyperdiversification/evolution of target enzymes. Furthermore, the platform is capable of transferring the diversified enzyme libraries to various bacterial hosts. To benchmark the platform, I aim to debottleneck the rGlyP by targeting its core enzyme, the glycine cleavage system (GCS) which catalyzes the rate-limiting step of glycine synthesis. Diversification and optimization of the GCS will be tested in dedicated selection strains from different bacterial hosts that can only grow if a functional GCS is expressed. Ultimately, optimized GCS variants will be expressed in a formatotrophic E. coli strain lacking a GCS. Improved formatotrophic growth will be analyzed in lab-scale bioreactors to determine techno-economic parameters required for the establishment of a formate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Fish Sperm Viability as an Indicator of Environmental Pollution.'.

assistant: **Concept**

The quality of sperm from European cyprinid fish will be assessed to determine whether this can provide a suitable indicator of the effects of pollution on freshwater and manne fish stocks. The effects of pollutants on sperm viability will be examined using Computer Assisted Sperm Analysis (CASA) and electron microscopy and compared with the effects on fertilisation rate. No results are yet available from the project.INTRODUCTIONStocks of freshwater and mane fish within the European Union are increasingly threatened by aquatic pollution, but no data are available on the extent by which fertility of individual species has decreased. The aim of the project is to develop a methodology to measure the impact of environmental pollutants on the viability of fish sperm, and to assess the impact of aquatic pollution on fish stocks within the EU.Recent concern about the effects of pollution has centred on the decrease in human sperm counts and the possibility that this may result from the feminising effects of environmental estrogens (Sharpe and Skakkebak, 1993). The link between estrogenic activity and decreased sperm counts is far from proven and the fact that a wide range of non-estrogenic environmental pollutants can also cause disruption of the reproductive endocrine system that may result in decreased sperm quality is frequently overlooked. Although such disruption may equally well decrease fertility in both sexes, one reason for the emphasis on the male is clearly the much greater ease with which human sperm quality may be assessed compared to egg quality.The effects of aquatic pollution on the reproductive endocrine system of fish are well documented (Kime, 1995), but there have been very few studies of its effects on gamete quality. While egg quality can only be readily
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mid-Infrared Solid-State Laser Systems  for Minimally Invasive Surgery' under Seventh Framework.

assistant: **Concept**

The goal of this proposal is to develop advanced table-top solid-state photonic sources for a specific wavelength in the mid-IR spectral range, as a practical, reliable and cost-effective alternative to large-scale free-electron lasers (FELs), for an important application in biomedicine (health): minimally invasive surgery. Recent experiments have verified that the use of mid-IR FEL at wavelengths near 6.45 µm, with a focused beam penetration depth comparable to the cell size and coupled both into the spectral wing of the water bending mode and the amide-II vibrational mode, results in tissue ablation with minimal collateral damage and very effective ablation rate. This finding is extremely important as a useful tool for minimally invasive human surgery. However, the clinical use of FEL is ultimately not viable due to large size, high cost, operational complexity and restricted access at a few million-dollar accelerator-based facilities worldwide. Several attempts to develop non-FEL alternatives have largely failed to meet the necessary requirements in terms of pulse energy and repetition rate. The main strategy in this project will be to exploit nonlinear optical techniques (OPO) in combination with novel near-IR laser pump sources (near 1 and 2 µm) and new materials (e.g. orientation patterned GaAs) to obtain an unprecedented energy level (10 mJ) near 6.45 µm at a repetition rate of 100 Hz (an average power of 1 W). Two basic approaches, differing in the time structure, will provide less than few µs (macro) pulse duration. The project encompasses four distinct elements: (1) Material research; (2) Pump laser development; (3) OPO development; and (4) Validation in tissue ablation experiments. The partners, 4 companies and 5 institutes from 7 member states, with proven t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'HYdrogel-based Matrices for Advanced Tissue Engineering' in the context of a Horizon Europe call.

assistant: **Objectives**

Tissue decellularization is a well-established technique in tissue engineering to preserve the biochemical complexity of native tissues. However, its application in recreating the tumor stroma for in vitro studies remains limited, with current models often relying on non-specific extracellular matrices that lack the unique characteristics of the tumor microenvironment. Here, we present a novel technology to develop hydrogels from decellularized tumor tissue using a tumor cell culture-derived matrix. This new technology, developed as part of the ERC project ICoMICS, improves the preservation of the composition of the matrix, in contrast to currently available alternatives. Hence, this technology creates a market opportunity to improve the development of hydrogels not only for cancer modeling, but also for a wide range of potential applications in disease modeling and regenerative medicine. In addition, by leveraging our extensive expertise in hydrogel characterization, we will expand our products not only for the production of specific hydrogels, but also for the characterization of all types of hydrogels according to the specific needs of potential users. Therefore, the main objective of this proof of concept is to assess the potential of this project to evolve into a spin-off company focused on: 1) commercializing novel hydrogels for tumor and disease modeling, and 2) providing potential customers with a wide range of accessible and thorough characterization methods.In addition, we aim to assess the market opportunities for both the commercialization of our hydrogel products and the establishment of a specialized characterization service providing in-depth physicochemical analysis of biomaterials for research groups and industry stakeholders.