RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Stability and Sensitivity Methods for Flow Control and Industrial Design' in the context of a Horizon 2020 call.

assistant: **Objectives**

Every day, society is demanding more efficient, safer, affordable and environmental friendly products. To do that, industry needs to innovate by developing new methods and tools able to obtain superior performances of their competitors.  This is the main topic of SSeCoID´s research: to develop new methods and tools for design in order to enhance their industrial performance.   SSeCoID will demonstrate its innovations by applying the new methods & tools to different problems of aeronautics and mechanical engineering, and will provide very specialized training to 15 researchers to make these novel technologies available to relevant industrial sectors.SSeCoID proposes to work in the:Development of new numerical methods and tools better suited for unsteady flows: stability analysis and high fidelity simulation, capable of capturing and controlling the growth of small perturbations in stable flows and able to provide enhanced accuracy.Identification of the features causing unsteadiness, acoustic, flow detachment or lack of performance of current aerodynamic configurations;Investigation of control/suppression of unsteady flow through flow control devices or surface modifications, by identifying the most suitable zones that have most influence on the flow features;Multidisciplinary evaluation of the most promising applications in relevant problems proposed by industry, including detached flows, acoustic feedback, flow induced vibration, inkjet or race car design; assessment of technical feasibility; potential of control devices for flow instability suppression or delay. Training 15 new researchers in the development of most advanced methods for simulation, feature detection, stability and flow control techniques applied to industrial design.Disseminate the project results in i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CD40 ligand-based modalities for the treatment of solid tumours' (APOTHERAPY).

assistant: **Concept**

The objective of this Apotherapy Specific Targeted Research Project proposal is to establish a European collective of international scientific excellence to combat cancer by translating basic research on key apoptotic pathways into tools which will improve the treatment and quality of life of cancer sufferers. The project will specifically aim to exploit the widespread expression of CD40, a TNF receptor family member, in human tumours and develop CD40 ligand-based modalities with high therapeutic potential and minimal side-effects. These translational studies are based on accumulating in vitro evidence suggesting that the activation of CD40 results in reduced proliferation and apoptosis induction selectively in cancer cells.The proposed STREP will develop vehicles for the efficient delivery of CD40L, such as CD40L-encapsulated liposome formulations and recombinant adenoviruses expressing CD40L and examine their in vitro and in vivo effects on tumour cell growth and metastasis. Apoptosis induced by CD40 engagement is dramatically augmented in the presence of inhibitors of the phosphoinositide 3-kinase (PI3 kinase) pathway which is frequently found activated in human tumours. The proposed STREP will expand on the development of inositol polyphosphates, novel PI3 kinase antagonists, and evaluate their in vitro and in vivo capacity to kill tumour cells and to amplify the CD40L-mediated effects on carcinoma cell growth, angiogenesis and metastasis. These studies will provide essential information for progressing the potential therapeutic strategy towards future clinical trials for the benefit of cancer sufferers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Actively learning experimental designs in terrestrial climate science' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

While land-atmosphere exchanges of carbon, water, and energy are key to understanding changes in the Earth system, we still fundamentally lack a methodology to obtain representative estimates of these surface fluxes at the scale of a single grid cell of an Earth System Model (typically 10-100 km), let alone for a wider region. ACTIVATE combines an observing system consisting of a swarm of drones carrying meteorological sensors and gas analyzers, mobile and stationary flux towers, as well as satellites, and fuses their observations with different land-atmosphere models using data assimilation methods. ACTIVATE will develop an adaptive Bayesian Experimental Design framework to generate maximally informative observation strategies for expensive data collection, and adaptively reposition drone swarms during a flight as new observations become available to optimally infer surface fluxes in the landscape. We will demonstrate the framework (i) in idealized synthetic experiments, (ii) at managed and industrial sites with known flux hotspots, and (iii) in targeted high-resolution simulations in poorly represented regions with expensive models that explicitly resolve subgrid-scale processes in Earth System models. We will apply the ACTIVATE framework around existing observatories in vulnerable arctic regions, where the lack of strong observational constraints from state-of-the-art observing systems is particularly apparent and problematic. ACTIVATE will produce: unprecedented observational datasets for new model developments in some of the most data-sparse regions on Earth, uncertainty-aware parameter estimates for critically unconstrained processes, and a pioneering active experimental design framework for terrestrial observing systems. The broader vision of ACTIVATE is to devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Mathematical models of lymphocyte homeostasis in hiv infection'.

assistant: **Objectives**

The work within the group headed by Prof. B. Autran described here represents a unique opportunity for the applicant to use her mathematical skills in the analysis of the data generated, and to have an input in the design of the experiments based on insights gained from the mathematical models. Theoretical studies are most useful in the context of collaborations with experimental laboratories, offering opportunities for mutual feedback. Hence, as the applicant is seeking to extend the number of collaborations with European centres -firm links exist with the group headed by prof. R.E. Phillips at the John Radcliffe Hospital, University of Oxford, as a result of the PhD work- the proposed work would be a major asset. The host institution will benefit from having an in-house theoretician because the reductionist nature of experimental work does not always allow for the synthesis of an overall picture of the essential workings of the immune system. Guidance in the theoretical work will be provided by dr. R de Boer (Theoretical Biology, University of Utrecht), who has a track record of publications with experimental groups in the Netherlands (profs F. Miedema, C. Boucher and I. Goudsmit) and elsewhere (G. Pantaleo).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cavity quantum electrodynamics control of magnetic phases in twisted van der Waals heterostructures' in the context of a Horizon Europe call.

assistant: **Objectives**

To further increase performance and reduce energy consumption in technological devices, a new paradigm is needed exploiting quantum mechanical phenomena. An attractive route to enter this paradigm is by interfacing light and magnetic excitations in new optomagnetic devices, which ensures processing frequencies comparable with electronics and hold great promise for future memory, spintronics and quantum computing devices. This, however, requires a deeper understanding of strongly coupled light-matter systems and the interplay between magnetic, electronic, photonic and lattice excitations. A promising platform to explore exotic magnetic phenomena is magnetic van der Waals (vdW) materials, since the competition of anisotropy, quantum fluctuations and spin-orbit coupling make these materials prime candidates to host such states and susceptible to material engineering techniques. This can be exploited in cavity quantum electrodynamics (c-QED) and Moiré engineering to control the magnetic state. By combining c-QED with Moiré engineering, the goal of CavityMag is to construct schemes to control the magnetic state of vdW materials and to induce exotic magnetic phases. This will be achieved by developing state-of-the-art computational tools based on quantum electrodynamical density functional theory (QED-DFT) in combination with effective spin-photon models. This computational framework will be used to perform a systematic study of light-induced magnetic phases in twisted vdW materials, to gain a deeper understanding of how microscopic magnetic interactions can be modified, and to establish concrete protocols to control the macroscopic magnetic state. It will also be used to guide experimental efforts by identifying candidate materials and parameter regimes likely to host exotic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Co-ordination of urban road-user charging organisational issues' to be submitted under Sixth Framework.

assistant: **Abstract**

This proposal directly responds to Part D of Activity Code 3.1.1, Research Domain 1.3, which addresses the following objective in the EC Programme: -Objective 1: New technologies and concepts for all surface transport modes (road, rail and waterborne)Overall ObjectiveThe CURACAO project will build on the work of CUPID, PRoGRESS and EUROPRICE, in the field of urban road pricing. The consortium comprises a wide range of key partners from those projects along with the Co-ordinator of IMPRINT-EUROPE. The project will ensure continuity from FP5 projects, but also brings in new partners with new ideas to widen the geographic and intellectual scope of the initiative.The overall objective of the project is:- to promote and support fairer and more efficient pricing of road usage in urban areas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Modelling of extreme gusts for design calculations'.

assistant: **Concept**

OBJECTIVES OF THE PROJECT For design load calculations for wind turbines it is necessary to determine the fatigue loads as well as the extreme loads. Up to now simple deterministic gusts (e.g. a cosine gust) are used to determine the extreme response. The form, amplitude and time period specified for these discrete events remain rather arbitrary and largely unvalidated. This is in contrast with the fatigue analysis, for which it is common to use a stochastic wind field based on the stochastic properties of real turbulence. The main objective of this project is to come to a realistic and verified description of extreme gusts based on the (stochastic) properties of wind. TECHNICAL APPROACH The project will make use of the applied method on extreme wave loading in the offshore wind energy project 'Opti-OWECS'. Furthermore full use will be made of the outcome of a Dutch study which will cover the topic in a preliminary way. The required wind data will become available through the developed database on wind characteristics. In essence the new method (called NewGust) to be developed in the project, describes a way to combine a stochastic time series (as used for fatigue analysis) together with a well defined deterministic gust shape (which can theoretically be derived) in such a way that a realistic extreme gust is obtained. The project approach can be divided into the following steps: 1. Experimental verification of the shape of extreme gusts. From theory it follows that the shape resembles the autocorrelation function of turbulence. This will be verified with the shapes derived from existing databases of wind measurements. 2. Determination of the probability distribution function of extreme gusts from databases of wind measurements or from theory (in case wind measurements
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Millimeter Wave Circular Dichroism Spectroscopy as a Powerful Tool for the Exploration of Molecules' to be submitted under Seventh Framework.

assistant: **Abstract**

By one of very important key for understanding biological processes is knowledge of structure of bio-macromolecules. These molecules have optical activity asymmetry which is connected with macromolecule structure and they absorb across the millimeter wave part of the spectrum due to collective vibrational modes. It is supposed that there will also be significant circular dichroism - differential absorption of left- and right-handed circularly polarized light. Since the biological material is chiral, this millimeter wave circular dichroism (MCD) spectroscopy would be a powerful tool for exploration of biomolecules. The very first millimeter wave spectrometer will be built. In addition, a packet of programs for driving the whole spectrometer and for analyzing obtained spectra will be developed. The last scientific objective will be measurements on interesting chiral molecules. The obtained MCD spectra will be proof that the constructed MCD spectrometer is sensitive biospecific tool. The experimental MCD spectra will also be compared with the simulated MCD spectra for determination of absolute configuration of molecules.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'How Mirror-Image Effects Shape Online Labour Markets' to be submitted under Horizon Europe.

assistant: **Abstract**

The 'gig economy', where workers are hired through internet platforms to complete a one-time service task (a 'gig'), is growing into a major labour market. Yet, we still lack a theory of how it develops. Its online part, including tasks to be completed at the computer (e.g. programming or translations), constitutes the first truly global labour market. Faced with unprecedented competition, most gig workers offer their services at low rates that do not allow for insurances or building up pensions. Several governments therefore consider making social security contributions compulsory. But can regulation at the national level protect workers in online markets, or will the demand for online gigs simply relocate to low-wage, low-protection economies?Based on an interdisciplinary framework of theories on varieties-of-capitalism, innovation systems, and entrepreneurial ecosystems, I propose a new institutional theory on mirror-image specialization: I hypothesize that education and labour-market institutions lead requesters, platforms, and providers of online gig work to specialize in hiring, transacting, and offering those skills that are least available in their home labour markets. This leads to specialization patterns in a countrys online gig economy opposite to those in its traditional labour market. If this is the case, my theory breaks ground for a new paradigm in institutional research of online markets and indicates that national policy-making can protect gig workers without risking the relocation of gig demand.To enable this theoretical high-risk/high-gain contribution, I will go beyond the empirical state-of-the-art of single-platform studies by collecting novel, large-N data on gig requesters (WP1), platforms (WP2), and gig providers (WP3). Using quantitative and qu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'iLifebuoy - saving human lives without endangering the lives of savers' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The objective of our business project is to help save human lives by entering the aquatic lifesaving equipment market forlifebuoys. The recent growth of the shipping and leisure sailing (wider seafaring) industry has in turn increased the risks andnumber of Man Overboard (MOB) situations leading to drowning at sea and rivers. Expected product - ‘iLifebuoy’ is anautonomous robotized lifebuoy that eliminates the challenges associated with the traditional life saving devices. Like the St.Bernard dogs, iLifebuoy autonomously finds & reaches the person and provides them first support.     The novelty - it is not a remote-controlled lifebuoy- it is a collaborative robot. iLifebuoy is a fully autonomous tracer, but it receives (video) input from a human.  It uses three different built-in sensors (audio, video and sonar) to pin-point the location of MOB in water, then activates a waterjet propulsion to reach and provide support to the MOB within less than a 2 minutes! iLifebuoy further sends a MAYDAY signal to channel 16 and emits the GPS coordinates of the MOB.   The advantages over all competitors – iLifebuoy saves crucial time in a MOB situation since: a) it does not require a qualified lifeguard to be around - the first person who identifies the MOB can directly deploy the iLifebuoy in the water; b) it effectively eliminates the need for lifeguards to enter the water and reach the person in distress. Our Primary market for product introduction will be watercrafts.       Conservative estimates of the ‘addressable/obtainable market’ (only 6.3% of the Total Available Market (TAM) indicate potential demand for 1.3M units growing at a CARG 5.7% YoY until 2024. Based on very conservative assumptions for production and market penetration we expect to reach 2.03% of the ‘obtainable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Primate models for studying fibrinolysis , thrombosis and tissue remodelling' in the context of a Fourth Framework call.

assistant: **Objectives**

To develop a complete methodology to study thrombosis, fibrinolysis, thrombolysis, and the plasminogen activator system, in primates (Macaca mulatta);To define base-line data regarding the normal physiology and regulation of these systems and their components in M.mulatta;To describe the effects of interventions on the functioning of the systems, to understand the pathophysiological changes that occur, in order to be able to improve the functioning of the systems in these circumstances;To develop non-human primate model systems for thrombosis, thrombolysis, and restenosis, in which models pathogenetic mechanisms can be studied, as well as the effects of therapeutic procedures and of drugs.Cardiovascular disease and consequent thrombosis is one of the main causes of death and morbidity in the Western world. Thrombosis is a main factor in vascular diseases such as angina, claudicatio, pulmonary embolism, thrombotic stroke, and endocarditis. Apart from these acute effects, thrombosis is also believed to play a major role in the slow progression of arteriosclerotic and atherosclerotic vascular lesions over time. Moreover, the fibrinolytic (plasminogen activator) system is intimately involved in tissue remodelling such as occurs during restenosis and wound healing.The occurrence of thrombosis is due to a imbalance between prothrombotic factors on the one hand, and antithrombotic factors on the other. Among the latter factors, the fibrinolytic system plays a major role. An insufficiently active fibrinolytic system will not succeed in removing forming fibrin fast enough to prevent the growth of a thrombus, and will also, once a thrombus has been formed, not be able to remove the thrombus rapidly enough to prevent ischemia and tissue damage.We still know little about the in viv