RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Immune mechanisms that control the homeostasis of the gut and that are deregulated in intestinal pathologies cancer.' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This project stems from an ERC STG grant that I received in 2007 (DENDROworld) in which we analyzed several aspects of the homeostasis of the gut and how defects in controlling this process could result in different pathologies, including inflammatory bowel disease (IBD) and cancer. In the present project, we will continue working on the immune homeostasis of the gut and we will focus on fundamental questions in mucosal immunity.Three important and novel questions will be addressed in this project. The first aims at understanding how the gut microbiota is restrained from reaching systemic sites and hence it is tolerated only locally. We think that we have identified a new barrier at mucosal sites that avoids systemic spreading of bacteria via the blood stream. This is a very selective barrier that resembles the blood brain barrier and occurs at the level of enteric endothelial cells. The second question is closely related and tries to identify the role of the microbiota in the establishment/maintenance of this barrier and to understand its role during infection with enteric pathogens or in other circumstances (like pregnancy, liver disease). Finally, we want to characterize the activity of an anti-inflammatory mediator that we have identified. This is a short isoform of the well-known cytokine called TSLP. We think that this isoform is the one involved in the homeostasis of the intestine as it is the only one produced by epithelial cells in health and is downregulated during chronic inflammation.This project is divided into three major aims.1. Analysis of a putative gut vascular barrier that resembles the blood brain barrier and of the mechanisms leading to its disruption2. Analysis of the role of the microbiota in the formation and maintenance of the Gut vascular barri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Fluorinated Heterocycles from Organosilanes: Novel synthetic approaches towards Fluorinated Lactones' (FLUHET), addressing dissemination and exploitation.

assistant: **Impact**

The proposed chemistry has been designed to provide versatile solutions to some significant problems associated with the synthesis of fluorinated products, more particularly fluorolactones. Beneficiaries of the science developed will be academics and pharmaceutical companies. The synthesis of F-organic compounds with proper functionality and favoured (drug-like) features are always of interest to pharmaceutical companies and their availability is key for successful discovery programs.The chemistry outlined in this proposal will develop unprecedented synthetic pathways allowing for the preparation of various fluorolactones, therefore expanding the repertoire of synthetic routes to these key compounds. The chemistry builds on our interest in the use of organosilanes as starting materials for the preparation of fluorinated compounds. In this project, we will study novel synthetic routes to fluorinated heterocyclic lactones from organosilanes using two complementary strategies: the iodolactonisation of allylic fluorides and the fluorolactonisation of structurally diverse allylsilanes.The application of this chemistry to the synthesis of a fluorinated analogue of GalNAc exemplifies how this chemistry could also contribute to the fundamental understanding of enzyme mechanism. The work will be undertaken at the University of Oxford (Chemistry, supervision Dr V. Gouverneur) by Dr M. Schuler who has recently completed her Ph D under the supervision of Professor L Ghosez (IECB).This project will allow her to acquire expertise in fluorine chemistry but also asymmetric synthesis and silicon chemistry, therefore complementing her existing skills. The results of her work will be disseminated with publications in the form or communications and full papers and it i s anticipated that t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Local structural disorder and Anharmonicity enabled low Thermal Transport and tracing Ionic Conduction in Efficient Ag2X (X: S, Se) thermoelectrics – A dual facetted study' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

EU's ambition of achieving climate neutrality by 2050 requires multifaceted approach, with a key focus on replacing fossil fuels with renewable energy sources. In this respect, thermoelectrics (TE) offers a promising solution by converting waste heat into electricity  contributing to global energy base  while addressing environmental challenges through decarbonization. A major barrier in the broader implementation of TE is the need for high-performance materials.Silver chalcogenides Ag2X (X: S, Se) have recently shown excellent TE performance near room temperature (RT: 300 K  400 K) owing to inherently low heat conduction (). Despite this, our understanding of their low  and their stability in the harsh operational conditions of a TE device remains uninvestigated. These aspects pose a significant challenge in advancing Ag2X as a viable alternative for TE near RT.LATTICE is a career development program designed for the researcher, aimed at developing structure-property relations in Ag2X to address stated fundamental and application-based aspects. To successfully achieve the goals of this interdisciplinary project, the researcher will undergo advanced research training in the host group  pioneer in TEs  at EUs leading University. The researcher will benefit from hosts strong expertise in studying materials structure by a wide range of experimental and theoretical methods and techniques. This opportunity will foster researchers growth in TE and materials science, positively impacting his long-term career trajectory.If successful, the project will unravel new knowledge of heat conduction in Ag2X and evaluate stability by unique measurement setup; emulating TE device operation conditions. LATTICEs research output will benefit colleagues working on other type of energy conver
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Role of mitochondria in mediating evolutionary rescue by anthropogenic pollutants in an invasive crab' to be submitted under Horizon Europe.

assistant: **Abstract**

Invasive alien species (IAS) are the cause of enormous socio-economic and biodiversity loss across the world. In the context of climate change and increased pollution, IAS are often more adaptive than native species, capable of adjusting their phenology in accordance with climatic changes, facilitating their invasion. It has been recently suggested that “rapid evolution” (allowing quickly adaption and avoiding extinction due to maladaptation), is the cause of the increased invasive capacity of IAS. In MitoRescue I take this concept one step further, and I hypothesize that mitochondria, being exquisitely sensitive to environmental stress and with a highly mutagenic DNA, are key organelles involved in rapid evolution resulting in “evolutionary rescue”. I will study the combined impact of pollutants and increased temperature on an ancestral and an invasive (recently established) population of the European Green Crab, an extremely prolific invader. The study involves both field and laboratory approaches, from the organelle to the whole-organism. It merges the fields of toxicology, physiology, evolutionary and molecular biology to provide a highly multidisciplinary and integrative perspective. The final objective of this research subject is to predict future invasion scenarios, identify novel targets to control IAS proliferation and improve management and risk assessments of IAS in Europe and worldwide. With MitoRescue I will use a state-of-the-art training in assessing mitochondrial plasticity to consolidate my career in Europe and compile the necessary data to establish a research subject new to the ERA with great translational impact. In the long-term, this research will promote “restoring Europe’s biodiversity”, which is one of the four current key strategic orientations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European Training Network on Integrating AI in Proteomics: From Data Acquisition to Translational Applications' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

ProtAIomiProtAIomics is a European Innovative Doctoral Network aimed at training the next generation of computational proteomics researchers by integrating advanced artificial intelligence (AI) methods with proteomics. Computational proteomics stands at the forefront of cutting-edge life science research, utilizing advanced data analysis and AI to decode the complex interplay of proteins in biological systems. Proteins, typically referred to as the workhorses of biological systems, are central to understanding cellular functions, disease mechanisms, the mode of action of drugs, and drug response. The network brings together 15 beneficiaries and 9 associated partners from diverse academic and non-academic sectors, including university hospitals, SMEs, and large companies, to tackle key challenges in the computational proteomics field.The network focuses on three main research objectives: (RO1) developing AI-assisted algorithms to maximize the extraction of high-quality information from raw mass spectrometry (MS) data; (RO2) creating advanced tools to transform this data into deeper biological knowledge through AI-driven models; and (RO3) applying this knowledge to generate actionable insights, such as precision drugs and clinical biomarkers, with a focus on advancing therapeutic applications.Through cross-disciplinary collaboration, ProtAIomics will bridge gaps in current proteomics research by enhancing data utilization, improving understanding of protein functions, and advancing AI tools for clinical applications. The network will provide comprehensive training, equipping doctoral candidates with exceptional AI application and development skills in an intersectoral, interdisciplinary and international setting, and improving their future employability. ProtAIomics is co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Regulation of Seed Storage Oil Mobilization (SOM) by the Phytochrome-Interacting bHLH Transcription Factors PIFs' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Storage oil mobilization (SOM) breaks down the reserve lipids in the seed and converts them to sugar. SOM is essential to support postgermination growth and seedling establishment, which are of foremost importance for plant fitness in the field. Light is the main environmental cue determining the transition between heterotrophic growth based on oil reserves and photoautotrophic growth supported by photosynthesis. SOM is faster in the dark-to-light transition compared to dark, indicating that the regulation of SOM needs to be tuned to the light environment of the emerging seedling. A current challenge is to define how the core enzymes in SOM are co regulated in response to light, which is of special relevance to plant growth and has profound implications in biotechnology. The phytochromeinteracting bHLH transcription factors PIFs are central regulators of plant growth, and are critical in the adaptation of seedlings to their light environment. PIFs have been shown to regulate key enzymes in chlorophyll, carotenoid, and anthocyanin biosynthesis in response to light. Recently, an Arabidopsis mutant deficient in four PIF proteins was found to have reduced oil body content in dark, suggesting that SOM is misregulated in the absence of the PIFs. The main objective of this proposal is to characterize how PIFs might be mediating light regulation of SOM. To achieve this goal, biochemical, metabolomic and molecular biology approaches will be combined to characterize in detail the light regulation of SOM enzymes and the role of the PIFs in their regulation. In addition, a cell biology approach will be used to characterize how SOM and light regulate etioplast development and transition to chloroplasts. Finally, a candidate gene approach will be used to identify novel regulators of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'RESCOOPs Mobilizing European Citizens to Invest in Sustainable Energy' (2014-2020).

assistant: **Concept**

RESCOOP MECISE is short for Renewable Energy Sources COOPeratives Mobilizing European Citizens to Invest in Sustainable Energy. As European citizens and local authorities often lack time, financial means and technical expertise to initiate the necessary energy renovations of their houses and public buildings, the potential for energy efficiency projects remains largely untapped. RESCOOP MECISE will develop an integrated and innovative approach that gives answer to this impeding challenge. By integrating both renewable energy and energy efficiency projects into one innovative investment scheme RESCOOP MECISE will elaborate a completely new financing format. The financing scheme will make European citizens, REScoops, local authorities, the European Investment Bank and other related investment funds partners into the transition towards a more sustainable society. Moreover RESCOOP MECISE will encourage citizens and local authorities to initiate deep energy renovation projects by providing them with personal assistance and technical expertise that now remains with the REScoops. The RESCOOP MECISE project will also provide a clear cut solution for the financing problem that REScoops face when they want to start up with their first project. By means of setting up a European fund for both renewable energy and energy efficiency projects or through the development of a financial facilitation service for REScoops the REScoop MECISE project will enhance the potential for more successful energy efficiency projects throughout Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ensuring clinical effectiveness and efficiency - closing the gap between scientific knowledge and practice, a collaborative project between the European Union and Southern Africa' under Fourth Framework.

assistant: **Concept**

* To establish whether common research models and implementation strategies are applicable to both EC countries and Southern Africa.* To link synergistically with a CA study funded by the BIOMED 2 programme entitled Bridging the gap between science and practice: How to change health care provider behaviour through implementing clinical practice guidelines" (short title: Changing Professional Practice) and any other relevant INCO funded projects in the Southern African region.* To build a network of mutually supportive researchers in Southern Africa and Europe (involving partners from at least three countries in the EC and three in Southern Africa).* To train researchers in Southern Africa in the methodology of systematic reviews, guideline development, guideline implementation, rigorous evaluations of guideline implementation and dissemination of findings of implementation research.* To publish the results of this process in peer reviewed journals and develop resource materials for training researchers (monographs, databases, E-mail discussion groups).* To work with the HealthLink and HealthNet networks - with the intention of thereby supporting their further development.Expected Outcome* The establishment of an implementation research network.* The submission of a further application to the EC for continued funding to support the conduct of individual projects.* Develop a network of mutually supporting researchers in Southern Africa and Europe.* Organise three education and training workshops to bring together European and Southern African participants in a collaborative network to support the development of research protocols for implementation studies.* Publish four newsletters in paper and electronic (via the World Wide Web) formats.* Develop training materials for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Characterizing Congo Basin Drought resilience: an Integrative Modelling approach' (COBADIM) targeting Horizon 2020.

assistant: **Abstract**

The African rainforest, is the second largest on Earth, covers ~630 million ha and stores up to 66 Pg of carbon and is presently a persistent carbon sink. In addition, African rainforest support the forestry sector which contributes 3-6% of the gross domestic product across the Congo Basin with most foreign export directed to Europe. As such, African rainforest currently represents both a local and foreign economic driver and provides important ecosystem services through the negative feedback on the global carbon cycle. Both remote sensing data and tree ring stable isotope measurements have shown that these forests are currently being subjected to a long-term drying trend, raising fears over the drought resilience of tropical tree species and the persistence and magnitude of this important terrestrial carbon sink. Here, we combine eco-physiological and dendrochronological research with a model based approach to increase our understanding of the response of African tropical tree species under changing climatological conditions across the central Congo Basin. We will integrate several data streams including inventory data on soil properties and associated leaf traits, wood traits, phenology, retrospective dendrochronology and wood core stable isotope and calcium tracer time series, in order to constrain a data-informed mechanistic ecosystem model (MuSICA). Using a novel tracer experiment we will corroborate the use of a calcium [Ca] tracer in tropical tree species for rapid dating and eco-physiological research into drought resistance. Accurate model predictions, based upon Ca tracer measurements made during this action, will provide estimates of the vulnerability of tree species to future drought conditions. Our results will have important policy implications as the demi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Wittgenstein and Political Theory' (WPolitical), addressing dissemination and exploitation.

assistant: **Impact**

The proposed research aims to investigate the relation between Wittgenstein’s philosophy and political theory. This theme remains marginal within the Wittgensteinian scholarship, facing the key challenge of the sparsity of explicit discussions of political issues in Wittgenstein’s writings. An extra challenge is raised by the fact that even in those cases that political theory is engaged with his philosophy, this is mostly done through a methodological rather than a substantive employment of its key insights and concepts. My main objective is to provide a novel approach to the relation between Wittgenstein and the political, by focusing not only on Wittgenstein’s methods, but also on his positions.The principal idea to be developed is that Wittgenstein’s philosophy may indeed provide a substantial contribution to political theory and especially to the analysis and critique of late capitalism. My innovative response to the challenges mentioned above will comprise an original research which will: a) make explicit the implicit political import of Wittgenstein’s later philosophy, b) investigate his influence on contemporary political theory, my case study being the works of Hardt and Negri, and c) enrich the discourse regarding the institution of society by providing it with a distinctive Wittgensteinian direction.The project combines elements from different philosophical disciplines (philosophy of language, political theory) and traditions (analytic, continental). Although I have a background in the philosophy of Wittgenstein and the analytic tradition, I have a limited training in political theory and continental philosophy. Thus, the proposed project, under the supervision of Prof. Antoon Braeckman who specializes in continental political theory, provides me with a great