RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biodiversity of microorganisms in aquatic systems' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The scope of this project is to assess microbial diversity from an ecologically relevant perspective, to relate this diversity to environmental factors (e.g. physico-chemical conditions, environmental changes, climate) and to analyse the contribution of microbes or microbial diversity to the overall biodiversity in lakes, taking into account endogenous ecosystem properties and responses to environmental stresses. It is intended to demonstrate that molecular markers, such as pigments and especially lipids, can be used for this purpose. Fairly stable lipids (hopanoids, sterols, gamma ceranes, etc.) will be analyzed in the water column and in the sediments of lakes. A total of 24 lake sites will be selected along the major climatic zones of Europe and with respect to trophic status of the lakes. It is assumed that stable lipids and pigments, ubiquitously distributed in the organic matter of lake sediments, can be used as markers of the diversity of living communities. To validate the results obtained on changes in lipid and pigment contents in relation to environmental changes, they will be compared to other approaches, in particular palaeoecological methods, primarily fossil remain studies (e.g. Diatoms, Ostracods, Cladocera). Further microbiological, biochemical and chemical laboratory experiments will be performed to validate the significance of lipids as markers. Finally multivariate statistical analyses will be employed to investigate the importance of environmental variables in explaining any differences in microbial diversity observed along the investigated time scales and environmental gradients. Finally, a model will be generated allowing a prognosis of changes in microorganism diversity in relation to environmental changes of global relevance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Comparative and experimental study of the bird immune defence and parasite load in relation to brood parasite and non-brood parasite species' (1994-1998).

assistant: **Concept**

Research objectives and content Avian brood parasitism is a reproductive strategy by which adult cuckoos lay eggs in nests of other species (hosts) which take care of the parasite offspring. Therefore brood parasite nestlings don't have any contact with adult cuckoos during their development resulting in a low rate of specific pathogen infection (Soler et al. 1998, J. Evol. Ecol, in press). The aim of this project is to study the influences of being a brood parasite in terms of risk of infection and level of inmmune response by comparing with non-brood parasite species. For the experimental studies we will use 'in vivo' immunological tests such as the T-cell response (by using phytohaemaglutinin injections), the level of immune globulines in the blood, sedimentation rate, haematocrit, etc. and there also will be used modern comparative methods, which take into account the phylogenetic relationships between species. The aims of this project are (i) to study whether brood parasites have a lower risk of infection and a higher level of immune response than their potential hosts; (ii) to test whether the availability of food is a factor determining the degree of differences in immune response between the great spotted cuckoo and its magpie host; and finally (iii) to study the genetic determinism of the level of immune response in magpie and great spotted cuckoo nestlings. Training content (objective, benefit and expected impact) By carrying out this project, I will develop a good knowledge in the use of comparative methods and experimental techniques in evolutionary biology and ecology and I will advance greatly my experience in scientific research. This training will also give me the opportunity to obtain the PhD degree. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Early detection of tumor DNA in liquid biopsies as a biomarker of cancer recurrence' (ONCOTECT) targeting Horizon 2020.

assistant: **Abstract**

Cyclomics BV is a Dutch start-up company with the ambition to disrupt the cancer diagnostics market with its proprietary circulating tumor (ct) DNA detection technology. Cyclomics has developed a ground-breaking sequencing methodology that enables reliable, fast and ultra-sensitive detection of cancer recurrence from blood samples (liquid biopsies).The first product, ONCOTECT, detects oncogenic mutations in the TP53 gene, and is developed for accurate and early detection of head and neck cancer (HNC) recurrence. Recurrent disease after initial remission is a main cause of cancer-related death. In HNC, radiological examination is the current standard in detecting cancer lesions but is unable to reliably detect recurrence early on, leading to treatment delays and lower survival rates. Integration of the ONCOTECT assay into routine clinical workflow is inexpensive and will provide faster time-to-results relative to competing sequencing methods.Since 90% of HNC patients carry specific oncogenic DNA mutations in the TP53 gene, the first application of this novel technology in recurrent HNC presents a considerable market opportunity for ONCOTECT. After achieving clinical proof-of-concept in a cohort of 20 patients, Cyclomics will offer its technology for licensing to a diagnostics company to further develop ONCOTECT as an in vitro diagnostic (IVD) kit and bring it to the market, with the aim of enabling superior quality in diagnostic and clinical decision making. ONCOTECT focuses on TP53 but the underlying technology can be applied to many different genes. Leveraging this potential, Cyclomics’ long-term vision  includes monitoring of cancer treatment response and early screening programs, encompassing various genes and cancer types, with the potential to impact the full spect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Mechanisms of Immune Receptor Diversification in Cereals'.

assistant: **Innovation**

The plant immune system is innate – it is encoded in the germline. In natural pathosystems, plants efficiently deploy hundreds of immune receptors to detect and disarm rapidly evolving pathogens including viruses, bacteria, nematodes, insects, fungi and oomycetes. Exactly how such receptor diversity can evolve is an elusive question with important practical ramifications. A central class of plant immune receptors, called Nucleotide Binding Leucine Rich Repeats proteins (NLR), has been implicated in recognition of vastly diverse pathogen-derived effector molecules. An emerging paradigm of receptor diversification in plant genomes involves new gene fusions of receptors with host proteins that are normally targeted by pathogen effectors. Such fusion receptors ‘bait’ pathogens and their integrated domains are thought to function as ‘decoys’ or ‘sensors’ that mediate pathogen recognition. I have recently demonstrated that the mechanism of generating new receptors through gene fusions originated at least 500 million years ago in mosses and is common to all flowering plants. Here, I propose to decode the mechanisms of plant immune receptor diversification by gene fusions by studying diversity and functions of immune receptors in grasses, a young highly diversified plant family that includes the three most important crops: maize, rice and wheat. My specific aims are to: 1) Determine rates of receptor diversification within and across genomes 2) Dissect the mechanisms of receptor regulation and receptor activation 3) Generate novel plant immune receptors based on the NLR platform prone to fusions. In this MIREDI research programme, I will combine state of the art sequencing techniques and bioinformatics, molecular biology and novel reverse genetics techniques to study how plant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A computer-aided study of the Luwian (morpho-)syntax' (SLUW).

assistant: **Concept**

The present project aims at analysing the morpho-syntactical  features of the Luwian language working on the available texts and combining a standard linguistic analysis with the implementation of a statistical analysis of the annotated corpus. By glossing the morpho-syntactical structure of a large selection of both cuneiform and hieroglyphic inscriptions using a protocol derived from and compatible with the Penn Treebank Project and the Leiden Glossing Rules, the research will proceed by isolating, mapping and modelling the regular as well as the anomalous features of the morpho-syntax of one of the most important and still largely unexplored languages of the ancient Anatolian branch of Indo-European. The analysis will also identify and focus on the co-dependant syntactical, morphological, semantic and stylistic phenomena present in the corpus (e.g. syntactic triggering of stylistic features, dislocations, topicalisations). The results of the present research will provide the world of the Indo-European studies with the first comprehensive study ever dedicated to morpho-syntax of the Luwian language.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Promotion and support of the transfer of scientific touring exhibitions at European level' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Among the popular products that offer a reliable and attractive presentation of the scientific knowledge to audiences unfamiliar with science, the Scientific Touring Exhibitions (STEX) represent a rich potential to be valorised at European level. Four well-experienced scientific institutions and the European Network for Science Centres and Museum (ECSITE) will create and promote the system (an on-line database) needed to stimulate the international transfer of STEX between Natural History Museums, Science Centres and museums at large.By promoting the best practices in transfer and raising membership to a system dedicated to professionals, e-CASTEX will set up in two years a system able to run on the long term thanks to the neutral organisation that is ECSITE. Hundreds of professionals are expected to get access to the European STEX production and consequently hire/rent more frequently these popular products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Second Language Tutoring using Social Robots'.

assistant: **Concept**

The L2TOR project capitalises on recent developments in human-robot interaction in which the use of social robots is explored in the context of teaching and tutoring. Social robots have been shown to have marked benefits over screen-based tutoring technologies, and have demonstrable positive impacts on motivation in learners and their learning outcomes. L2TOR focuses on the domain of second language learning in early childhood: due to increased mobility of European citizens and increasing internationalisation, most children in Europe will be required to fluently use two or more languages. As language acquisition benefits from early, personalised and interactive tutoring, current language tutoring delivery is often ill-equipped to deal with this. As resources are insufficient to offer one-to-one tutoring with (near) native speakers in educational and home contexts, L2TOR will further the science and technology of language tutoring robots, with a strong focus on multimodal interactive tutoring for young children (4 years of age). L2TOR will focus on native speaking Dutch, German and Turkish children learning English. In addition, Turkish immigrant children in the Netherlands and Germany will be supported by a robot in acquiring Dutch and German. To realise this ambition L2TOR needs to address both technical aspects -such as multimodal interaction, human-robot interaction management and social signal processing-, pedagogical aspects -such as exploring the pedagogy of social robots and the use of social robot to assist in language tutoring- and developmental psychology aspects -such as understanding how children learn a first and second language from others and how this can be transposed to learning from robots.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Open Ocean Fish farms' (OCEANFISH).

assistant: **Concept**

Gili Ocean Technologies aims to become the leading off-shore (Open Ocean) aquaculture company. This will be achieved through the operation of fish farms as well as through the delivery of turn-key projects for other fish farmers based on our extensive off-shore fish farming expertise and advanced technologies.  Aquaculture is rapidly growing. The FAO estimates that aquaculture will grow to over 62% of the worldwide supply of fish protein by 2030.However, the currently near-shore aquaculture faces significant problems e.g. relatively slow growth rate for the fish, high death rates, low stocking densities in the cages and intensive use of antibiotics in order to fight diseases. In addition, significant pollution in the coastal areas is very common as there is hardly any dispersing of organic matter in the ocean. This impacts the local ecology as well as the industry itself. OCEANFISH aims to finalize the development and start the commercialisation of the various technologies necessary to transform Gili's existing Subflex Classic systems to advanced and sophisticated open ocean systems improving growth rates, reducing ecological impact and providing the aquaculture industry with the tools necessary to meet the market demands. This is a significant market opportunity. To capture this opportunity, the OCEANFISH project aims to 1) increase the cost-efficiency of the Subflex aquaculture platform, 2) enable real off-shore farming, 3) enable growth of additional fish species and 4) commercialize the technology.  The OCEANFISH system is a flexible submerged system of cages. The original technology was developed with the Technion, Israel's leading technological university. OCEANFISH is an excellent example of how humans can take better advantage of oceans in a highly sustainable m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cytokine Receptor Signaling Revisited: Implementing novel concepts for cytokine-based therapies' to be submitted under Seventh Framework.

assistant: **Abstract**

Cytokine receptor signaling is an essential part of the intercellular communication networks that govern key physiological processes in the body. Cytokine dysfunction is associated with numerous pathologies including autoimmune disorders and cancer, and both cytokines and cytokine antagonists have found their way into the clinic. Yet, there are still many unfulfilled promises and opportunities. In this project we will reinvestigate key aspects of cytokine receptor activation and signaling using novel insights and techniques recently developed in our laboratory. This will include the AcTakine concept for cell-specific targeting of cytokine activity, and applications of our MAPPIT, KISS and Virotrap toolboxes to systematically map protein interactions involved in cytokine signaling. We expect to obtain important new insights, both in fundamental and in applied medical sciences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Coordination of European funding for infectious diseases research', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Infectious diseases (ID) also known as communicable diseases are one of the majorcauses of death worldwide. Every year in Europe, infectious diseases cause tens of thousands of deaths (from ECDC ‘Microbes without borders: key facts on infectious diseases in Europe’ 2007 report).In order to address the challenges in ID and design adapted treatments, as well as diagnostic and preventive tools, the funding programmes involved in The INFECT-ERA aim to support all basic aspects of human infection biology caused by bacteria, fungi, viruses and protozoa. To that end, research addressing the cross-talk between host and pathogens, as well as the relationship between microbes’ environment and infection will be supported by Infect-ERA. In addition, this ERA-NET aims to (i) strengthen the development and improvement of innovative tools and methodologies to address infection biology as a whole and (ii) promote the integration of new tools to carry out research.Infect-ERA consortium is comprised of 14 participants from 11 countries. It will build on the established network of National Funding Bodies that are participating in the ERA-NET of PathoGenoMics and will bring in new ones. With the accession of new partners the organization of the network will be updated. It will strongly rely on PathoGenoMics’s achievements, such as the establishment of principles and mechanisms for the evaluation of joint calls and for the management of transnational projects. Infect-ERA will therefore concentrate on funding high quality and cutting edge research through yearly Join Transnational Calls (2013-2016). It will also contribute to the European mobility initiatives and strengthen the European research by expanding the young scientist support initiated in PathoGenoMics, and facilitating the mobilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ni-CAT' (Ni-CAT) under Horizon 2020.

assistant: **Objectives**

The Ni-CAT project aims at boosting the catalytic activity of Ni for effectuating challenging oxidation and bond formation reactions. As a key concept to achieve this goal, the metal centers will be combined with mesoionic ligands, a class of ligands that is able to transiently store and release electrons and that is thus particularly suited for assisting a coordinated metal center in effectuating electron transfer processes. This metal-ligand synergy alleviates the limitations typically encountered for bond activation processes with nickel, which often undergoes one-electron redox changes only. This concept renders catalytic transformations with this less reactive metal center energetically feasible and eventually efficient and will introduce a new paradigm in using Earth-abundant metals in homogeneous catalysis. The exploitation of intrinsic metal ligand cooperativity for electron transfer provides a compelling strategy to develop a sustainable process towards efficient C–H bond activation that is not dependent on precious metals. The project provides an excellent training in one of the most topical areas of catalysis and its successful completion will greatly enhances the career profile and the research competence of the researcher, thus actively contributing to the fostering of young talents and for prospering scientific excellence in Europe.