RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multi4 - the first surgical instrument for bladder cancer treatment through a 20-minute outpatient procedure' (Multi4) targeting Horizon Europe.

assistant: **Abstract**

Bladder Cancer (BC) is the most overlooked cancer type in terms of the development of new surgical tools aimed at achieving efficient cancer treatment. The instruments used in the operating room have remained unchanged since the 1960s. The standard of care involves a rigid metal cystoscope and a surgery under anaesthesia. The inherent risks to the patient are manifold, encompassing damage to the urethra, frictions, infections, and the potential reseeding of cancer cells elsewhere in the bladder. The lack of progress in this field is evident in the statistics: this cancer type has the highest recurrence rate of all cancers - up to 75%. In BC, approx. 60 % of healthcare costs are attributed to patient surveillance and treatment of recurrences. BC remains one of the most expensive cancers to manage and treat globally.Multi4, established by the experienced surgeon and women innovator Miden Melle-Hannah, is developing a ground-breaking surgical instrument that allows for effective treatment of BC in outpatient settings. This innovation transforms the patient's healthcare journey. Instead of the waiting period for difficult and hazardous surgeries, patients can now have their tumours removed directly in the urologist's office. This advancement is made possible through cutting-edge deep tech innovations in instrument engineering design. These innovations result in a surgical tool which integrates four functionalities (thus we call it Multi4): 1. Inject local anaesthesia through a thin needle; 2. Remove cancerous tissue using specially coated forceps; 3. Transport the cancer tissue out through the instrument itself; 4. Burn the area where the cancer was located to ensure the elimination of all cancer cells.This project will close the gap to market for Milti4 through clinical st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

INMARE stands for “Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea”. It is  a collaborative Innovation Action to streamline the pathways of discovery and industrial applications of new marine enzymes and bioactives for targeted production of fine chemicals, drugs and in environmental clean-up applications.The INMARE consortium will unify the multidisciplinary expertise and facilities of academic and industry partners. This will include integrating the following core activities: advanced technologies to access and sample unique marine biodiversity hot-spots; state-of-the art technologies for construction of metagenomic libraries; innovative enzyme screening assays and platforms; cutting-edge sequence annotation pipelines and bioinformatics resources; high-end activity screening technology; bioanalytical and bioprocess engineering facilities and expertise, nanoparticle-biocatalysts; high-quality protein crystallization and structural analysis facilities and experts in IP management for biotechnology. The companies involved in the project are market leaders in enzyme production and biocatalysis processes designed to efficiently deliver safer (pharmaceuticals) cheaper (agriculture) and biobased (biopolymers) products. They also have impressive track record in environmental clean-up technologies and are committed to promoting  public understanding,  awareness  and  dissemination of scientific research. The main emphasis will be focused on streamlining and shortening the pipelines for enzyme and ‘bioactive compound’ discovery towards industrial applications through the establishing of marine enzyme collections with a high proportion of enzymes-“allrounders”. The project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Open Superior Efficient Solar Atmosphere Model Extension' in the context of a Horizon Europe call.

assistant: **Objectives**

The goal is to develop a time evolving model for the entire solar atmosphere, including the chromosphere and transition region, based on a multi-fluid description. At present, models are steady, rely on a single-fluid description and include only the corona due to computational challenges. We plan to use time-evolving ion-neutral and ion-neutral-electron models. The multi-fluid approach will enable us to describe the intricate physics in the partially ionized chromosphere and quantize the transfer of momentum and energy between the atmospheric layers. The questions where the solar wind originates and solar flares and coronal mass ejections are driven have both fundamental scientific importance and substantial socio-economic impact. Indeed, the solar atmospheric model is the crucial missing link in the Sun-to-Earth model chain to predict the arrival and impact of CMEs at Earth.What makes this goal now possible is the combination of our implicit solver with a high-order flux-reconstruction (FR) method. The implicit solver avoids the numerical instabilities that lead to strict time step limitations on explicit schemes. The high-order FR method enables high-fidelity simulations on very coarse grids even in zones of high gradients. We will start from this new development and introduce three critical innovations. First, we will combine high-order FR with physics-based r-adaptive (moving) unstructured grids redistributing grid points to regions with high gradients. Second, we will implement CPU-GPU algorithms for the new heterogeneous supercomputers advanced by HPC-Europa. Third, we will implement AI generated magnetograms to make the model respond to the time-varying photospheric magnetic field which is crucial for understanding important properties.We will thus develop a fir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Novel Imaging of the heart for new structural and metabolic diagnosis' under Horizon 2020.

assistant: **Concept**

Each year cardiovascular disease (CVD) causes over 4 million deaths in Europe. Predictions suggest that 80% of premature heart disease and stroke is preventable, but ~20% of CVDs are misdiagnosed, and in elderly patients up to 60% of CVDs remain undiagnosed. We need to develop new technologies and strategies for early and accurate diagnosis of the biggest killer in western society.Currently, diagnosis of CVD is based on assessment of macro-anatomy, whole heart function, and whole body metabolic markers. Early CVD processes begin in heart cells, before evolving to the ’macro’ pathology recognisable by traditional techniques. Clinicians desire a non-invasive technique that can provide high-resolution 3D micro-anatomy, and organ specific regional metabolic assessment. However the intricate micro-anatomy of the heart and its dynamic relationship with cardiac function is still fiercely debated.To elucidate the true micro-anatomy of the heart, and understand its correlation with both pump- and metabolic function in health and disease, I will investigate the following questions:1)What is the true micro-anatomy of the heart, and how is it remodelled in disease?2)What is the role of 3D micro-anatomy in 4D pump function?3)Does micro-anatomical remodelling correlate with regional changes in metabolism?Using novel state-of-the-art non-invasive 3D and 4D ex-vivo and in-vivo imaging methodologies, I will answer these questions. We will finally understand the micro-anatomy of the heart in 3D, and its relationship with cardiac contraction and metabolism in disease. I hypothesise detecting and correlating novel morphological and metabolic changes upstream of the macro-anatomical and non-specific metabolic changes identifiable by traditional techniques, will offer the foundation for a st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LILY: A Breakthrough Technology to Prevent Chemotherapy-Induced Hair Loss' (LILY).

assistant: **Concept**

Chemotherapy-induced alopecia (CIA) is hair loss associated with chemotherapy treatment for cancer. LILY is a portable, comfortable, and effective CIA prevention device that uses localised microvasculature compression therapy (LMCT) to prevent CIA. The LILY device uses this unique LMCT technique to reduce perfusion at the scalp and prevent the destructive action of chemotherapy on hair follicles. By applying a consistent low-level pressure (between 35 and 60 mmHg) to the local micro blood vessels, which could deliver chemotherapy drugs to fast-dividing hair follicles, the vessels are temporarily compressed, inhibiting drug delivery.The device comprises a proprietary pneumatic bladder network design and soft robotics system with the ability to non-invasively induce vasoconstriction in superficial vessels of the scalp to mechanically control tissue perfusion, and an electronic control system for both patient management of the system and real-time feedback into the treatment protocol.


**Keywords:** Automation and control systems,Micro (system) engineering,Business model innovation,Chemotherapy-induced alopecia,Chemotherapy,Breast cancer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Persisting Transgenesis' (PERSIST) under Seventh Framework.

assistant: **Objectives**

For many disabling or fatal diseases, there is pre-clinical or clinical evidence of the potential therapeutic efficacy of gene therapy and, yet, the limitations of current gene transfer technologies have prevented success or even caused serious adverse events leading to termination of trials. PERSIST will explore the use of highly innovative gene-modifying and delivery technologies and capitalize on recent discoveries in gene expression control to develop radical solutions to the problem of precisely controlling the fate and expression of exogenous genetic information in gene therapy with applications in these and other deadly diseases. Our proposal combines 20 of Europe’s outstanding experts from 8 countries in the field of genetic engineering for persisting gene expression. Partners have pioneered the use of Zinc Finger Nucleases, engineered recombinases and transposases for gene targeting, synthetic promoters, epigenetic switches and micro-RNA for regulating gene expression, developed state-of-the-art gene delivery platforms based on lentiviral, AAV and gutless adenoviral vectors, conducted front-line clinical trials, and productively collaborated in previous FP projects. PERSIST includes 16 work packages of which 6 focus on vector innovations (part A: emerging technologies), 6 on applications & evaluation (part B), 1 on process development and the remaining 2 on training/dissemination and project management including IPR issues. Targeting deadly diseases, such as inherited immunodeficiencies, storage disorders and haemophilias, PERSIST is in line with the Strategic Research Agenda (SRA) of the Innovative Medicines Initiative (IMI) and will result in: faster discovery and development of better medicines; more attractive professional environment for scientists; better
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Finance, Innovation and Growth: Changing Patterns and Policy Implications'.

assistant: **Innovation**

The long-term economic performance of Europe depends on its ability to generate new knowledge and inventions, and, to translate invention into innovation and innovation into economic adaptation and growth.This ability is central to achieving the objectives of the Lisbon Agenda and the new industrial policy in an enlarged EU.However, innovation involves more than invention, more than the funding of science and technology and R&D.It is in relation to the exploration, manufacturing and commercialisation of novelty that the analysis financial markets is of the first importance.Their dependence on effective arrangements to supply finance and monitor and redistribute the returns to innovation is our central concern.We approach these issues from different angles: analysis of different modes of bank and venture funding, operation of equity markets and innovation, effects of finance on the selection dynamics of market growth and evolution, and study of consequences of modes of financing innovation for the distribution of income and employment generation.This last point is key since different modes of financing of innovation, investment and corporate growth are likely also to entail far reaching consequences in terms of employment dynamics across different types of firms.FINNOV tackles these priorities by bringing together the expertise of scholars from the fields of economics of innovation, applied industrial economists, political economists and business historians to investigate the interconnections and implications between recent changes in the patterns of financing, innovation and industrial evolution, and the ensuing dynamics in corporate growth employment and income distribution.By exploring the interactions between financial structure, productivity, profitability, investme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The European initiative for identifying Genetic loci predisposing to spontaneous Hypertension and its complications Program' in the context of a Fourth Framework call.

assistant: **Objectives**

Objectives:ù Identify the genes responsible for genetic hypertension, its associated conditions and its major complications in rat models of human hypertension.ù Understand the mechanisms by which these genes influence blood pressure, the associated phenotypes and risk of end-organ damage.ù Apply the data towards better understanding of the genetic basis of human hypertension and its complications.Brief description:Hypertension is a multifactorial trait with a strong (30-50%) but polygenic genetic component. Understanding the genetic basis of hypertension and its associated conditions is of fundamental importance if novel and specific approaches to both prevention and treatment are to be realised. In a previous Concerted Action (EURHYPGEN) under BIOMED 1 members of the network mapped several quantitative trait loci (QTLs) that influenced either (i) blood pressure (ii) associated phenotypes or (iii) end-organ damage, in crosses of genetically hypertensive and normnotensive rats. The objective of EURHYPGEN II is to move from this knowledge of the chromosomal location of the QTLs to the identification and characterisation of the causative genes themselves. For most QTLs the current precision of localisation is at the 20-30 cM level. The first aim is to narrow down the segment containing the QTL to 1-2 cM (the current limit of resolution by linkage). This will be achieved through the construction and phenotypic analysis of congenic strains containing increasingly smaller segments of the chromosomal regions of interest. Subsequently, physical mapping strategies will be used to identify the responsible genes. In the absence of obvious candidate genes to analyse, this will be based on (i) the assembly of a set of Yeast Artifical Chromosomes (YACs) containing the whole of the r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An easy way to access GRID resources' (A-WARE) targeting Sixth Framework.

assistant: **Abstract**

Project strategic objectiveThe A-WARE project will develop a stable, supported, commercially exploitable, high quality technology named A-WARE able to give easy access to Grid resources. A-WARE will primarily target the Grid Foundations topic of the above-mentioned strategic objective.Starting pointsThe project will be based on the EnginFrame Grid portal experience and on Unicore/GS technologies; EnginFrame is a framework developed by NICE, this tool is adopted by a wide number of important companies worldwide; EnginFrame is the base of the GENIUS portal adopted by EGEE; Unicore/GS is the outcome of several projects, and represents one of the most mature European middleware available today.Guiding principlesThe guiding principle of the project will be to exploit and leverage the maturity of the Unicore/GS software components, developing a technology able to easily widen the adoption of Grid technology via a web thin-client approach based on user-friendly interfaces, hiding the complexity of the underlying Grid middleware to occasional as well as frequent users. To facilitate the exploitation, particular care will be put on simplifying the deployment of the Grid under typical industrial scenarios, such as Intranet security, single-sign-on systems, etc. Finally, another guiding principle of the project will be both to adopt and influence standards in all key project areas.Project brief descriptionThe design phase will address the coupling between Unicore/GS and a generic open source portal technology; the framework will be designed addressing the full service / job-flow life-cycle (design, submission, validation, execution, monitoring, data management and virtualisation), including industry-focused AAA, SLAs, QoS and presentation issues; at the same time it will guarantee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Measure, Design and Compensation for Thermal Deformations'.

assistant: **Objectives**

The main objective of the project is to reduce the thermal deformations of machine tools and measurement equipments (CMMs) by changes in the design and by compensation methods. Thus the first step of the project is to improve the thermal design of the machines and generate a methodology to allow industrial companies to apply these techniques without external help. A further step is to compensate the residual deformations in the improved machines. The academic partners will develop and compare up to six different estimation algorithms to choose which best suits under industrial conditions. Linear thermal deformations will be compensated by means of the CNC and the angular deformations, physically, actuating over the machine (heat actuators...). As result of the forementioned activities, our project tries to develop a methodology to adjust the parameters of the compensation algorithm to each new machine in a test of duration less than 12 hours. Finally, a new laser measurement device, based on theodolite principle, will be developed. It will allow to take accurate position readings in several different locations of the machine during the long thermal tests. Our improved design methodology, compensation algorithms and measurement device will be tested independently in one large milling machine, in two grinding machines, in a lathe and in a coordinate measurement machine; therefore providing the ability to extent these results to other very different machines.