RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Simultaneous Localization and Mapping for Augmented Reality' (SLAM4AR), addressing dissemination and exploitation.

assistant: **Impact**

The PoC Project SLAM4AR is focused on developing technological foundations for advanced augmented reality (AR) applications on smartphones.  According to a recent study of Hampleton & Partners, the market value for AR applications is expected to break the $170 billion barrier by 2022.  And a significant share of this market value will come from smartphone applications.  In the PoC project SLAM4AR, we will build up on state-of-the-art algorithms for visual Simultaneous Localization and Mapping (SLAM) that we developed in the ERC CoG “3D Reloaded”.  These algorithms allow one to recover the motion of a camera and a 3D reconstruction of the observed environment at unprecedented precision, robustness and large-scale capability (among existing real-time capable algorithms).  We will reformulate and streamline these algorithms so that they can run on smartphones.  They will leverage the smartphone’s camera and inertial sensor in order to compute in real-time both the location of the phone and a 3D map of the environment.  In several AR applications, we will demonstrate that our algorithms with their superior precision and robustness serve as a key enabler for advanced AR technology. For example, we can perform object insertion (beyond Pokemon Go) in a way that dynamic objects interact more naturally and faithfully with a complex 3D environment – they accurately sit on chairs or tables, or they convincingly roll down slopes, etc.  This will enable numerous AR applications such as teaching medical students about the 3D location of bones and inner organs, training novice car mechanics in the inner structures of a motor. Or navigating tourists to a desired location in a museum or a church. There is a rapidly growing market for AR applications on phones and we are convinced that o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Indo-European Network in Mathematics for Health and Disease' under Seventh Framework.

assistant: **Concept**

The main aim of this proposal is to set up an Indo-European Research Network in Mathematics for Health and Disease, INDOEUROPEAN-MATHDS, that will allow the transfer of knowledge, research and training between partners.  The Network will involve physicists, mathematicians, statisticians, probabilists, biologists, immunologists and engineers.  The Network will create new collaborations and reinforce existing ones to develop a lasting and fruitful research cooperation between all partners.  Other objectives of this proposal are:(1) Establish research collaborations between the experimental, clinical and theoretical partners of the Network to develop mathematical and computational models for health and disease.(2) Establish research collaborations between the different theoretical groups to discuss, compare, test and validate different modelling approaches.(3) Train a new generation of multi-disciplinary (experimental, clinical and theoretical) scientists, with the aim to exchange postgraduate students and research fellows, so that they benefit from the broader knowledge, skills and tools provided by the Network.(4) Enhance the international outreach dimension of the EU partners by delivering lectures and seminars at the LANL q-bio series of Summer Schools and Conference, and the training events to be organised and hosted by the Indian partners.(5) Enhance the international dimension of research in India in the area of Mathematics for Health and Disease, by organising and hosting four training events (spring schools) in India.(6) Enhance the international outreach dimension of the LANL q-bio series of Summer Schools and Conferences.A final research objective of the Network is to develop, by means of the Research Staff Exchange Scheme, four long-term directions in Mathemati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'App on AR-Smartglasses for improved autonomy and mobility of visual impaired persons' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Plusindes is a private company born with the main mission of providing visually impaired people with solutions to assist their very complicated daily living. Visual impairment, also known Low Vision, is a condition caused by eye disease in which the ability to see is decreased to a degree that causes problems not fixable by usual means, such as eyeglasses, contact lenses, medicines or surgery. With low vision it is hard or impossible to do many of normal daily tasks such as driving, reading, socializing or walking. It is therefore a disabling condition that affects very negatively the quality of life of affected people, who lose their autonomy and thus become highly frustrated and depressed in most cases. Furthermore, visual impairments have considerable economic costs both directly due to the cost of treatment and indirectly due to decreased ability to work.Retiplus will offer low vision patients a usable and versatile solution for improved mobility, accessibility and autonomy that will not imply them suffering from the social awkwardness of wearing a signpost in their heads to advertise their disability. Retiplus is a patented technology to compensate vision impaired troubles based on wearable augmented reality (AR) smartglasses which basic mode of action is exploiting the residual vision of visually impaired people to assist them in daily activities. It is calculated that there are more than 285 million people who were visually impaired of which 246 million have low vision and 39 million are totally blind. This unfortunate picture of the reality is in fact the validation of the Retiplus investment opportunity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Correlative smFRET/electrophysiology for long-term studies of protein dynamics' (COSMO).

assistant: **Concept**

The conformational dynamics of proteins are essential for their proper functioning, and impaired dynamics can lead to disease. However, it remains difficult to experimentally determine the multitude of conformations adopted by proteins, their lifetimes and the transitions between them. Single-molecule FRET (smFRET) is probably the most suitable technique available due to its ability to operate under ambient conditions while avoiding ensemble averaging. Yet the technique is limited by the short observation times (a few seconds) and the difficulty of measuring more than one molecular distance at the same time.The goal of this proposal is to develop an innovative correlative approach that can extend smFRET observations to much longer timescales, while also providing a way to integrate multiple measurements into a coherent molecular picture. I will do so by combining smFRET measurements with nanopore-based electrophysiological experiments that have a high temporal resolution and are also sensitive to conformational changes. Our corelative system will thus combine the speed and the sensitivity of electrical readout with the direct observation of molecular distances using smFRET. We will apply this methodology to map conformational dynamics of the biologically-important Ras proteins. We expect that this project will allow us to develop our innovative methodology and claim the novelty of the concept. This new methodology should open entirely new opportunities to monitor fast and long-term conformational dynamics of proteins or assembly processes of macromolecules.


**Keywords:** single-molecule FRET, nanopore, electrophysiology, protein dynamics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Generation of stem cell derived photoreceptors for the treatment and modelling of retinal degeneration' (STEMRD) under Seventh Framework.

assistant: **Objectives**

Retinal degenerations leading to loss of photoreceptors are a major cause of untreatable blindness in the EU. Age-related macular degeneration (AMD) affects 1 in 10 people over 60 yrs. Currently no treatments restore lost photoreceptor cells and visual function and thus there is a need for new therapeutic approaches. We have shown previously that transplantation of rod precursor cells at a specific stage of development results in integration and differentiation into rod photoreceptors (Nature, 2006) and that this can improve vision in mouse models of visual dysfunction (Nature, 2012). These studies provide proof-of-concept for effective transplantation of neurons and the basis for ES cell-derived photoreceptor transplantation. Importantly, these results are only achieved using photoreceptor precursor cells that are specified to differentiate into photoreceptors, but are not mature photoreceptors at the time of transplantation. The objective of this proposal is to determine if ES/iPS cell-derived photoreceptors can be utilised as a therapeutic source of cells to repair the degenerate retina and to model photoreceptor disorders. We will build on our achievements in the field of donor photoreceptor cell transplantation and determine if mouse and human ES cells have the potential to provide an efficient source of rod photoreceptor precursors for restoring vision. A key requirement for the development of retinal stem cell therapy is effective generation and transplantation of ES-derived cone photoreceptor precursors. We will modulate differentiation pathways in order to enrich for cone precursors and investigate their ability to restore visual responses in animal models of cone dysfunction. Finally, we will develop protocols for generating mature photoreceptor cells with out
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Imaging influenza nucleic acid recognition by RIG-I in living cells'.

assistant: **Innovation**

Despite of intensive research the last decades, viral infection still represents a serious threat to human health. One crucial aspect of the defence against viral infection is the activation of the host innate immune response. Recent advances have highlighted the crucial role of the RIG-I receptor in triggering IFN synthesis upon virus infections. This virus sensing pathway mediated by RIG-I is crucial for successful host defence against negative stranded RNA viruses infection such as influenza virus. Influenza viruses are common pathogens responsible for recurrent seasonal respiratory illness and pose a serious threat to public health. Part of the virulence of influenza virus is due to its ability to manipulate the innate immune system. Therefore it is important to understand the mechanism of influenza detection by the RIG-I receptor. Much work in the host and other laboratories has contributed to our understanding of how influenza infection initiates the activation of RIG-I and the identity and properties of RIG-I agonists are well defined. However, the kinetics, subcellular localization and mechanisms underlying this recognition still remain unclear. This question of the localisation of virus recognition and the accessibility of the RIG-I ligand is stressed by the subcellular site of virus replication. For example, the replication cycle of influenza virus occurred in the nucleus of infected cells. Therefore it is quite puzzling how RIG-I that has been described to be a cytoplasmic receptor could be able to interact with the viral genome. The overall goal of this project is to develop a non-invasive technique that allows visualization and localization of influenza nucleic acid replication to analyze its detection by the RIG-I innate immune receptor in living cells. Do
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of chitosan-containing polyelectrolyte blends for medical applications' in the context of a Fourth Framework call.

assistant: **Objectives**

The aim of the project is to develop new polymer materials that have considerable potential for application in a number of areas in the biomedical field such as wound dressings, artificial ''skin'' for treatment of burns and drug-release systems. The novelty in the proposal is that the polymer materials will be intimate blends of chitosan with a number of other natural polymers such as alginic acid, heparin and hyaluronic acid. all of which are bioactive and it anticipated that considerably synergy will result from their combination. Such blends have been impossible to prepare to date because the chitosan interacts in solution with the other polymers listed to form insoluble precipitates which are neither readily soluble. nor mouldable by heat and pressure, so cannot be converted to usable forms. It is anticipated that a recently discovered novel method of solubilising chitosan will prevent this precipitation and allow intimate blends of chitosan with these other polymers to be produced for use in medical applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Deep screening of proteins with a next generation sequencing platform' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Next generation sequencing (NGS) has become an indispensable tool for system biology and has recently been adopted in protein engineering science as well. This proposal describes the development of a highly generalizable technique, termed FUNC-NGS, which links in situ functional information of protein activity with the function-determining DNA sequence in a massively parallel manner opening exciting possibilities, e.g., in drug discovery. In this method a cell-free display platform is combined with NGS by modifying protein display units to contain unique homing oligonucleotide sequences. These units are subsequently targeted to bind monoclonal DNA clusters in the flow cell of an Illumina sequencer by complementary DNA hybridization. FUNC-NGS is readily compatible with a paired-end sequencing programme on the Illumina platform and the number of screening units is only limited by the number of DNA clusters on the flow cell. As the first application challenge, a new variant of a modified bacterial adhesin, Spycatcher, will be created with an altered specificity for synthetic biology applications. Novel Spycatcher-SpyTag pairs are intensively desired but their creation is demanding. Solving this problem will be a perfect showcase for this radically novel deep screening technology. At the mature stage FUNC-NGS will be a transformative platform in therapeutic protein development, functional genomics and personalized medicine. The proposed work will be carried out at Dr. Hollfelder´s laboratory at the University of Cambridge with a short secondment at Medimmune. Hollfelder group has developed SNAP display, which is a FUNC-NGS-compatible in vitro protein display system. Furthermore, the University hosts excellent facilities for NGS sequencing and experienced bioinformatics supp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Holistic Surface Water and Groundwater Management for Sustainable Cities' in the context of a Horizon 2020 call.

assistant: **Objectives**

Urban water management becomes progressively more challenging in the view of population growth and increasing complexity of water management infrastructure. In this line, there is an ever increase demand from the water providers’ and public authorities’ perspective to critically evaluate the existing water ecosystems at city level in respect to the water supply, waste water treatment, reuse potential and the effect the growing population has on the water ecosystem and endangered species. To enable effective decision making at the entire city level, both surface water and groundwater should be viewed as part of the overall urban water ecosystem with its spatio-temporal availability, quantity and quality and competing uses being taken into account. The Water4Cities project will rely on sensor technologies, data and visual analytics to enable localization, visualization and analysis of urban water (both surface water and groundwater) at a holistic urban setting providing services to multiple water stakeholders. More specifically, the Water4Cities project aims to develop the necessary models and associated platform that will enable water providers and relevant stakeholders to a) monitor in real-time the urban water resources; b) support their decisions for optimal urban water management causing minimal environmental impact and c) involve policy makers, corporations and the public to provide the support for sound and balanced decision-making.  Beyond the scientific results, Water4Cities will target the exchange of knowledge among project partners. The Water4Cities project requires the collaboration of researchers in different research areas, i.e., water management, urban infrastructure management, sensor networks, data mining, data visualization, system integration, urban pl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Valorisation of biorefinery by-products leading to closed loop systems with improved economic and environmental performance', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The Valor-Plus supports the realisation of sustainable, economically viable closed loop integrated biorefineries through the development of new knowledge, (bio-)technologies and products that enable valorisation of key biorefinery by-products. The project comprises five key areas:• Pre-treatment and fractionation: development of a novel methodology for the controlled and selective breakdown, release and fractionation of the lignocellulose biomass to minimally degraded cellulose, hemicellulose and lignin fractions that are suitable for further downstream refinement and processing to value product streams• Hemicellulose Valorisation: engineering of new enzymes and microorganisms for the controlled hydrolysis and transformation of hemicellulose to high value oligomers and bulk fermentation product streams (butanol, ethanol and single cell proteins for animal feed)• Lignin Valorisation: utilisation of combined chemo-enzymatic and chemo-microbial processes for the controlled depolymerisation and transformation of standardised lignin feedstocks to discrete families of platform and intermediate macromolecular and monomer chemicals; and their subsequent transformation to value product streams (fuels, platform chemicals, monomers for synthesis of resins and functional additives)• Glycerol Valorisation: engineering of new microorganisms that are the suitable for the fermentation of crude glycerol to higher value product streams (lipids, alcohols and organic acids)• Demonstration of the technological and economic potential for integration and scale-up within existing and future biorefinery value chains: including: demonstration of component technologies, focused biodiesel refinery case study, roadmaps for technology and product stream integration, and a full life cycle assessmentT