RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'PATHway: Technology enabled behavioural change as a pathway towards better self-management of CVD' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cardiovascular disease (CVD) is the leading cause of premature death and disability in Europe and worldwide, costing the EU economy almost EUR 196 billion a year. With changing demographics and deteriorating lifestyle this situation will worsen considerably. While effective cardiac rehabilitation (CR) improves mortality and morbidity rates, uptake of community-based CR, which represents the long-term rehabilitation phase (III), is very low across member states (approximately 11%). Numbers are further diminished by low adherence rates. Key reasons for this include: severe lack of programmes, travel time, scheduling issues, lack of peer mentoring, and low self-efficacy associated with poor exercise technique and perceived poor ‘body image’ (not wanting to exercise with large groups of ‘strangers’). PATHway proposes a radically novel approach to CR that will ensure a paradigm shift towards empowering patients to more effectively self-manage their CVD, set within a collaborative care context with health professionals. It has the potential to deliver significant cost savings to the healthcare system, and direct more appropriate utilization of healthcare resources. This will be achieved via a patient-centric holistic approach that specifically addresses the above barriers. PATHway will provide individualized rehabilitation programs that use regular, socially inclusive exercise sessions as the basis upon which to provide a personalized, comprehensive lifestyle intervention program (managing exercise/physical activity (PA), smoking, diet, stress management, alcohol use etc.) to enable patients to both better understand and deal with their own condition and to lead a healthier lifestyle in general. This will be made possible by the provision of an internet- enabled, sensor-based
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Disentangling anthropogenic and natural causes for global coastal hypoxia'.

assistant: **Innovation**

Dissolved oxygen is an essential substance for a large portion of marine biota. Hypoxia, the reduction of dissolved oxygen concentrations to levels which are detrimental to the health of aerobic organisms, is currently expanding throughout the world's coastal areas, creating a negative impact from both the environmental (e.g. reduced biodiversity, reduced population growth, formation of 'dead zones') and economical (loss of fisheries) perspectives. Through the development and usage of local to global scale biogeochemical models, this research addresses past, present, and future formation of hypoxic 'dead zones' as a result of human-induced nutrient loadings and climate change. These topics are relevant for both industry and society, as they include the effects of changing river nutrient export to coastal marine ecosystems on the increasing frequency, extent, and duration of hypoxia. These studies will serve to further constrain nutrient reduction strategies and their effect on the amelioration of hypoxia in various coastal environments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovative drugs targeting IDO molecular dynamics in autoimmunity and neoplasia' (DIDO) under Seventh Framework.

assistant: **Objectives**

Catabolism of amino acids is an ancient survival strategy that also controls immune responses in mammals. Indoleamine 2,3-dioxygenase (IDO), a tryptophan catabolizing enzyme, is recognized as an authentic regulator of immunity in several physiopathologic conditions, including autoimmune diseases, in which it is often defective, and neoplasia, in which it promotes immune unresponsiveness. The PI’s group recently revealed that IDO does not merely degrade tryptophan and produce immunoregulatory kynurenines but also acts as a signal-transducing molecule independently of its enzyme activity. IDO’s signaling function relies on the presence of phosphorylable motifs in a region (small IDO domain) distant from the catalytic site (large IDO domain). Preliminary data indicate that IDO, depending on microenvironmental conditions, can move among distinct cellular compartments. Thus IDO may be considered a ‘moonligthing’ protein, i.e., an ancestral metabolic molecule that, during evolution, has acquired the DYNAMIC feature of moving intracellularly and switching among distinct functions by changing its conformational state. By means of computational studies, Macchiarulo’s group (team member) has identified distinct conformations of IDO, some of which are associated with optimal catalytic activity of the enzyme whereas others may favor tyrosine phosphorylation of IDO’s small domain. A switch between distinct conformations can be induced by the use of ligands that bind either the catalytic site or an accessory pocket outside the IDO catalytic site. The first aim of DIDO is to decipher the relationships between IDO conformations and multiple functions of the enzyme. A second aim is to identify small molecules with drug-like properties capable of modulating distinct IDO’s molecular confo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quantum Universal Photonics Integrated Circuit platform' under Horizon Europe.

assistant: **Concept**

Quantum technology holds the promise of enabling next generation computing, communications and sensing systems. However, the size, cost and scalability of current devices prevents them from reaching their full potential. Photonics is one of the key enabling technologies for quantum technology. In particular, photonics integrated circuits (PICs) with their wafer-level manufacturing based on microfabrication technologies can provide the reduction in size and cost and enable next generation scalable quantum technologies. To fully achieve this goal, an universal PIC technology that can serve most quantum applications is needed.In QU-PIC, we selected the Al2O3 integrated photonics platform as backbone technology for the development of quantum PICs thanks to its excellent low propagation loss performance and wide operating spectral region from the ultraviolet (200 nm) until the mid-infrared. A large range of PIC building blocks is developed in QU-PIC, focusing on areas where materials or integration technologies are not yet available. Several light sources, including multiwavelength tunable lasers with operation at 399 nm, 411 nm and 935 nm on the PIC, UVC external cavity lasers emitting at 280 nm, sources of squeezed photons, single photon detectors, programmable ASICs and the required packaging and assembly technologies will be investigated. An open PDK will group all the developed quantum building blocks to accelerate innovation from the initial idea to an actually manufactured system. Two application demonstrators will be implemented using the developed building blocks, namely a source of GKP states for quantum processing and an atomic clock based on Yb+ ions for quantum sensing. It is the ambition of QU-PIC to secure a full European supply chain to establish Europe’s Sov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mitochondrial Medicine: developing treatments of OXPHOS-defects in recombinant mammalian models.' to be submitted under Seventh Framework.

assistant: **Abstract**

Mitochondria are the major source of ATP, synthesized by the mitochondrial respiratory chain (MRC) through the process of oxidative phosphorylation. ATP deficiency leads to cellular dysfunction and ultimately death. In mammals, 13 mitochondrial DNA (mtDNA)-encoded subunits interact with over 70 nuclear-encoded subunits to form four of the five MRC complexes. Many additional factors are essential for the regulation of MRC activity, and the maintenance and expression of mtDNA. As a result, genetic defects affecting either genome can compromise ATP synthesis and cause human disease. There is no effective treatment for mitochondrial disorders. Major hurdles to this achievement include (i) the still incomplete molecular definition of mitochondrial disease; (ii) the poorly understood function of many disease gene products, (iii) the difficulty to rationally manipulate the complex biochemical and genetic systems underpinning mitochondrial bioenergetics.The ultimate scope of MitCare is to develop effective therapy in mitochondrial medicine. MitCare will implement three Workpackages (WP). WP1 will test the effects of pharmacological stimulation of mitochondrial biogenesis in mouse disease models. WP2 will test the effects of Adeno-Associated Viral (AAV)- and lentiviral-mediated delivery of therapeutic genes, in mouse models and human mutant cells, respectively. Since the clinical features of human disorders often fail to be faithfully replicated in mice, WP3 will implement the creation of a mitochondrial disease model in the pig, whose proximity to humans is much closer than mice. The Surf1 gene, encoding an assembly factor of complex IV, will be disrupted by zincfinger nuclease technology in swine fibroblasts, which will then serve to clone a Surf1 knockout pig by somatic cell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'GENDER NARRATIVES AND POLITICS IN THE MONGOLIAN SACRED GRASSLANDS' (MONGOL-GNP) targeting Horizon 2020.

assistant: **Abstract**

This anthropological project investigates how sacred sites and connected ritual activities reflect gender narratives and political hierarchy among the Mongols in the People’s Republic of China. To put it another way, what can a monastery or a shamanic grave tell us about the evolution of gender roles and political legitimacy within a local community?For centuries, people have constructed religious sites to benefit from the magical power they are believed to provide. In the grasslands of Inner Mongolia, local people also build and worship at sacred monuments to ensure the fertility of their herds and the well-being of their community. Besides their accredited ritual power, religious sites also offer an accurate overview of the way local societies have been shaping the different social and political norms regulating their everyday lives. By taking religious sites as the starting point, the project explores two intertwined issues. The first analyzes the way gender practices have been narrated and performed throughout the 20th century in order to shed light on changing indigenous interpretations of sex difference and complementarity. The second examines how memorable characters and other mythical ancestors have redefined the political landscape of Inner Mongolia. More precisely, this focuses on how power holders gather and demonstrate authority, respect or allegiance to the administrative political powers. Sitting astride anthropology, gender studies and religious studies, the project combines ethnographic fieldwork with oral and written sources to provide a comprehensive framework of the changing social organization of the Mongols of China in terms of gender and politics. Taking Mongolian societies of China as a case study, this project will also echo contemporary issues t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Re-use of foundations on urban sites' (RUFUS), addressing dissemination and exploitation.

assistant: **Impact**

The re -use of foundations in congested urban areas is key to providing sustainable modern accommodation and maintaining economic growth and continued redevelopment. This project will provide construction professionals, clients and end users with economic, environmentally acceptable processes to provide sustainable foundation systems for the next generation of buildings in urban centres.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Personalized bioinformatics for global cancer susceptibility identification and clinical management' under Horizon 2020.

assistant: **Concept**

Cancer sequencing studies have extensively investigated the landscape of somatic mutations that drive tumor development, however the importance of germline variation for cancer susceptibility has been neglected. We hypothesize that for cancer types affecting a large proportion of the population, a shared set of genes with variants of different levels of penetrance leads to the clinical phenotype. While rare germline variants are not interrogated by array-based genome-wide association studies (GWAS), these can be effectively studied by whole-genome or whole-exome sequencing. Here, we propose in-depth pan-cancer analyses, which will be implemented as part of the International Cancer Genome Consortium (ICGC) initiative, as a model to develop and apply the necessary bioinformatics tools and pipelines to fully exploit the cancer-genome datasets, and to harness the diagnostic power of genome sequencing in day-to-day clinical practice. Our proposal addresses the full chain of computational and statistical tools that are needed for clinically relevant diagnosis and intervention, including discovery in large cohorts, validation of putative causal sites in model systems and development of targeted cancer-risk panels. The consortium combines complementary expertise to extend the computational discovery of novel variants that influence cancer susceptibility to intergenic and regulatory variants; to integrate genomic, molecular phenotype, biomarker and clinical data; and to develop novel statistical methods for variant association and eQTL analysis. The project will deal with essential aspects on how data are collected, stored, organized, integrated, analyzed and exploited in cancer genetic clinics. We aim to provide a concerted, cross-disciplinary framework for a better understandi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular Probes for Biofouling monitoring in Membrane Processes' (ProBioMem).

assistant: **Innovation**

The core concept of this research project is the development and exploitation of specific molecular probes as innovative tools for monitoring membrane processes in-situ and at molecular level overcoming the limitations of the traditional techniques employed. Project objectives will be achieved through the incorporation, at membrane surface, of molecular probes sensitive to oxygen and able to provide information about the oxygen concentration at the boundary layer related to the growth of biofouling. This will allow to monitor the biofilm onset by monitoring the oxygen change in concentration due to its consumption, when aerobic microorganisms are used, or due to its production, when microalgae are used. In particular, the proposed approach will be very beneficial in such processes where oxygen depletion or production takes place, such as membrane bioreactors (MBRs). The properties exhibited by the smart membranes containing the molecular probes, will allow measuring the oxygen concentration in real time, in-situ, at molecular level and by means of a non-destructive technique. The possibility of knowing a priori the biofouling onset occurring at membrane surface and caused by aerobic microorganisms or microalgae will represent an important breakthrough for the improvement and optimization of the overall membrane process. It will enable, in fact, a precocious intervention steered to mitigate the biofouling formation before the resulting decline of membrane performance.


**Keywords:** molecular probes, biofouling, membrane bioreactors, water treatment, smart membranes, molecular sensors, oxygen monitoring, luminophores, polymeric membranes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Optimisation of Energy Integrated Pressure-Swing Distillation Processes for Separation of Homogeneous Azeotropic Mixtures' to be submitted under Sixth Framework.

assistant: **Abstract**

The separation of homogeneous azeotropic mixtures via pressure swing distillation is an important chemical engineering problem. The currently known studies deal mainly with the process feasibility, distillation- and energy- efficiency, and the control prop erties of different possible configurations. The considered configurations include continuous, semi-continuous and batch.The proposed project aims at the systematic analysis of these distillation configurations in order to achieve optimal economic performa nce. The scope of the study includes optimisation of the design variables such as equipment capacities, characteristic sizes and throughput, and operational optimisation - including process control performance. The control problems to be considered include start-up, stability and load change problems. Buffer tanks and additional reboilers/condensers will be evaluated as options to improve the dynamic performance. The performance of the three configurations for pressure-swing azeotropic distillation - contin uous, semi-continuous and batch - will be compared and the best application cases will be identified for each. To achieve these research objectives, rigorous process models of the discussed distillation configurations will be developed and validated. This will be followed by the development of optimisation models and optimisation procedures for each case. With regard to the objectives of the Specific Programme and the Work Programme, the proposed project will enhance the research potential and industrial pr actice of the European Community in the area of azeotropic separation. This will be achieved by bringing together the current expertise of the researcher in process optimisation and design with the remarkable track-record of the host institution in the res ear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New wearable measurement devices for Industry 4.0 based on gaming motion-capture system' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

ERGOVIAKinematix is a disruptive innovation in the area of Smart Factory targeted predominantly at automotive and mechanical engineering sectors. It is a complex HW&SW solution comprising wearable smart measuring device with sensors capable of eliminating magnetic field data infringement, high-capacity data unit with a Big-Data analytical tool and a unique software capable of real-time recognition and evaluation of biometric position of fingers (in 3D) based on globally used ergonomic methods. There is nothing comparable to our solution at the global market.The product solution is targeted at automotive and mechanical engineering sectors that comprise an estimated number of 5 000 companies in the EU, 16,3 mil. employees and about 250 automobile assembly and engine production plants in the Europe. Our solution is capable to identify manufacture efficiency increase up to 30% in terms of time and 25% in terms of manufacture efficiency (by means of lean operations elimination). Moreover, our specific approach (via ergonomic measurement) is primarily oriented on workers´ welfare and thus, reduces risks of most common occupational disease – musculoskeletal diseases. Concept of the product is based on customers´ feedback and identified market gap (absence of sensors resistant to metallic objects´ magnetic fields that influence the accuracy of measured data e.g. in engine manufacturing lines). We plan to implement the whole project within 30 months (6 months Phase I, 24 months Phase II). The expected costs of these two phases are app. 1,57 mil. EUR. By 2022 our project will generate a turnover of 8,75 mil. EUR and 25 new jobs created. Our goal is to have a 15% EU-market share in consultancy services by 2025.