RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Feasibility of mCura1: A kidney-targeted nanomedicine that promotes self-healing of Chronic Kidney Disease with messenger RNA.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Chronic Kidney Disease (CKD) is a little-known disease, but does affect 10-13% of the population in Europe and constitutes the 9th cause of death. Hallmark of this disease is loss of kidney function, leading to the progressive loss of the ability to clear metabolic waste and produce kidney-specific hormones. The consequences affect the entire body (heart attacks, anaemia,osteoporosis and cognitive decline) and ultimately become life-threatening. Management of these consequences with currently available drugs or dialysis does not stop, but merely slows the progression. The only alternative is kidney-transplantation, which is a very limited solution due to a donor-shortage and the relatively short survival of the transplant. In addition, these treatments frequently cause severe side-effects, resulting in a problematic decrease in quality of life. The chronic nature of the disease, the high number of patients and the high number of drugs per patient, together place a large (financial) burden on the healthcare system, consuming 4-17% of the European healthcare budgets.In pursuit of the first curative treatment for CKD, Mercurna is developing a kidney-targeted nanomedicine, mCura1. The unique selling point of mCura1 is the combination of the enhanced safety provided by kidney-targeting and the efficacy provided by mRNAbased therapeutics.Mercurna has booked very promising results in pre-clinical studies accumulating in several patent applications. In the NanoMed-CKD project, Mercurna will further develop its business plan to support the (clinical) development path to bring this groundbreaking therapy from lab to clinic to market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mathematics Gabon Africa' (MaGA) targeting Horizon Europe.

assistant: **Abstract**

Mathematics in Gabon for Africa project brings together a broad spectrum of mathematicians covering the expertise needed to make substantial progress in several directions insofar as they bring into play common knowledge and inspirations. MaGA project is highly international projects, implemented by consortia involving three European and five African countries.Built around a core of researchers in sub-Saharan Africa (based in Burkina Faso, Gabon, Mali, Republic of Congo and Senegal), it aims to develop a large-scale intercontinental collaboration, starting from and multiplying the forces present. Africa's economic development cannot be achieved without its skills, particularly the most qualified. We aim to train a new generation of African mathematicians able to actively participate in the development of their universities and their country, in collaboration with the international community, and to organize scientific training meeting the needs of local non-academic organizations. MaGA project will train the future trainers, establish the scientific potential and influence of the African and European researchers and develop attractive and relevant local doctoral training.  It offers a coherent strategy to build demanding training adapted to economic and social local needs and to strengthen North-South-South capacity.  It aims to create in Gabon within 10 years a center of excellence in mathematics, a place of regional convergence of Research and Innovation initiatives open to the non-academic world.The scientific project explores a broad spectrum of open theoretical and applied questions in mathematics and includes a speculative component opening towards the non-academic world.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The conference new perspectives in nordic food research and innovation (NFRI)' (NFRI), addressing dissemination and exploitation.

assistant: **Impact**

The conference New Perspectives in Nordic Food Research and Innovation (NFRI) will focus on areas of research crucial to success in the food markets of the future - and arrange brokerage. Key topics:a) Market oriented product development,b) structural change in the food marketing chain,c) food safety,d) Knowledge Management,e) Understanding the consumer. By:A) Identify key resources and competences,B) Create strategies which guide to long term building of key internal resources,C) Motivate and reward people to contribute,D) organise the interface between product development, production and market strategies,E) Build motivation and trust in development networks,F) include market research Understanding the consumer" to work for consumer's choice and public health."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Regional modelling of dairy sector and Assessment for a sustainable development in a less-favoured region - Reunion' under Sixth Framework.

assistant: **Concept**

A substantial share of livestock production in the world takes place in harsh environments with high agro-ecological constraints and uncertainties. This agro-climatic and socio-economical environment conditions farmers' decision-making process and also the priorities for the sustainable development of the livestock sector.The objective is to develop:- a regional model to assess the impacts of technical or agro-environmental policies change on the viability and sustainability of livestock farming systems (LFS),- integrating farmers' attitude to risk, especially in the resource management, that appears as a key factor to understand efficiency of LFS, and environmental challenge.The regional model has to assess the impacts of agro-environmental measures on the viability of LFS, the environmental and social sustainability in harsh environment that suffer from lack of employment. This regional model should be used as decision-support tools by decision-makers, at the local but also national or community levels, to implement appropriated policies for a sustainable development.The specific objectives are:- to integrate some environmental risks and the environmental risk perception by farmers on a modelling approach to analyse the impact of agricultural change due to external interventions on the environment,- develop a prospective approach of the social, economic and environmental dynamic of rural area oriented on livestock production,- develop local competence on bio-economic modelling at regional level.At the end, this ToK project will improve:- collaboration between European research institutes,- develop modelling competences in economics and environmental research at La Reunion, but also in the host institute with extension in other are as, especially in developing countrie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A SCORING SYSTEM FOR ONLINE CONTENT' (Factmata).

assistant: **Innovation**

Organisations (governments/brands) face major issues and are finding it increasingly difficult to tackle information warfare and emerging defamation threats on social media. Rumour mongering, false claims, and aggressively toxic opinions online have severe detrimental effects. Many policy and product launches are executed without granular awareness of how they might be received according to what stance the public is taking, and arguments the public is making in relation to a specific product/policy issue. Stock prices can also take a major hit. Many organisations (PR/Financial analysts/Governments/Agencies) use media analysis to monitor mentions of themselves online; however, current social listening and media monitoring tools are limited: they cannot perform sophisticated detection of key arguments and who is making them, and cannot thus identify useful influencers; they offer poor quality sentiment analysis via keyword detection which does not give insight as to the reason for sentiment, nor explain what rumour or claim caused it to change. Factmata aims to solve this challenge through development of an intelligent media analysis system that can detect and cluster claims, rumours, opinions, arguments, and stances in social media, news and blogs using natural language processing. Unlike current solutions which are limited by simple keyword analysis of media to provide tracking around sentiments, our solution provides algorithms and an interface that can detect, cluster and track claims, rumours, opinions, arguments and stances toward key topics (such as medical/clinical topics or political policy related topics). This enables PR campaign analysts to fully understand how public opinion is shifting on key policy discussions and thus optimise PR and social media messaging
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Selection and affinity maturation of recombinant phage antibodies to tumour-associated HLA antigen/peptide complexes' to be submitted under Fourth Framework.

assistant: **Abstract**

The prospects for cancer immunotherapy rely on the identification of tumour-associated cell surface antigens and their specific recognition, e.g. by cytotoxic T lymphocytes (CTL). Antigens recognised by tumour-specific CTL consist of peptides derived from endogenous proteins and presented by human major histocompatibility (HLA) class I molecules, ideally only on tumour cells. Several such polypeptides have been described in the past two years, e.g. in melanomas. Another target is the tumour suppressor p53 protein, overexpressed in more than 50% of all human malignancies and recognized by CTL in the context of HLA-A2, the most frequent HLA class I allele. However, despite their exquisite specificity, CTL have a number of shortcomings in comparison to antibodies, in particular with respect to production, handling and general applicability. These difficulties may now be overcome by replacing tumour-specific CTL with recombinant phage antibodies recognizing HLA/peptide complexes. With phage display, reagents can principally be made completely in-vitro, by-passing the immune system and the immunization procedure, and allowing in-vitro tailoring of the specificity and affinity of the antibody. However, despite the availability of efficient screening procedures, in-vitro affinity maturation strategies are still in their infancy. They still need considerable improvement to allow maturation of selected antibodies in batch rather than on an individual basis. Therefore, this project seeks to identify recombinant antibodies directed against certain HLA class I molecules complexed with peptides derived from tumour-associated antigens. Molecular immunological technologies will then be employed to improve the affinity of selected reagents. This will lead to the development and exploit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Next generation European system for cattle improvement and management' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The Gene2Farm project will address the needs of the cattle industry, in particular of the SMEs and end users, for an accessible, adaptable and reliable system to apply the new genomic knowledge to underpin sustainability and profitability of European cattle farming. Gene2Farm will undertake a comprehensive programme of work from statistical theory development, through genome sequencing, to address new phenotyping approaches and the construction of tools, that will be validated in conjunction with SMEs and industry partners. Advanced statistical theory and applications will use the genomic and phenotypic information to optimise and customise genomic selection, breeding and population management and between breed predictions. The project will sequence key animals and exchange data with other international projects to create the most comprehensive bovine genome sequence database. Detailed analysis of these genome sequences will define genome structure, shared alleles, frequencies and historic haplotypes, within and between populations. This information will be used to optimise the informativeness of SNP panels and select SNPs to tag haplotypes, and hence ensure that genotype information can be used within and between breeds. The project will explore the opportunities for extended phenotypic collection, including the use of automated on farm systems and will develop standardisation protocols that, in consultation with ICAR, could be used by the industry for data collection and management. Developed tools will be tested and validated by demonstration in collaboration with dairy, dual purpose, beef and minority breed organisations. Finally a dissemination programme will ensure that training needs of the industry are served from an entry level training programme for farmers to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A Complementary Approach to Aromatic Synthesis by Diels-Alder Reactivity Followed by Desaturative Photoredox, Cobalt and HAT Triple Catalysis.' to be submitted under Horizon Europe.

assistant: **Abstract**

Aromatic molecules are integral to every aspect of chemistry. In general, the preparation of these compounds is approached via the use of aromatic precursors that are progressively functionalized using reactivity like electrophilic/nucleophilic aromatic substitution. Derivatives equipped with electron withdrawing groups (ester, ketone...) are particularly used in synthesis but are often challenge to prepare. This is because aromatic chemistry has to follow some stringent selectivity rules that activate or deactivate specific positions. This means that installing a functionality on a deactivated position (e.g. meta in an electron rich aromatic) is very difficult and requires many steps.This project seeks to address this challenge by developing an innovative approach to aromatic synthesis using simple Diels-Alder cycloadditions to construct a six-carbon cyclic framework followed by an unprecedented desaturation process. In particular, we will demonstrate the integration of three catalytic modes, photoredox + cobalt + HAT catalysis, as blueprint to progressively desaturate Diels-Alder cycloadduct to poly-functionliased aromatics. This reactivity will streamline the preparation of many high-value but difficult to make aromatic products, will be used in late-stage functionalizations and will substantially expand the fields of dual photoredoxcobalt catalysis and boryl radical chemistry.This research capitalizes on recent developments of the Leonori group that has experience in the development of methodologies based on both desaturation and boryl radical reactivity. The completion of such an innovative and ambitious project at RWTH Aachen University will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my future career following
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Compact porous medium burner and heat exchanger for household applications'.

assistant: **Objectives**

Objectives The objective of the present project is to advance development work on a porous medium burner with an integrated heat exchanger. This burner does not work as a catalytic combustor, but burns with flames within the pores of a porous medium. Combustion in porous media offers an interesting and potentially promising route towards burners with high power density, high power dynamic range and very small amounts of emission products. Technical Approach The research and development work of this project is based on results of Porous Medium Burner with integrated Heat Exchanger (PMB-HE) developments at the LSTM-ERLANGEN. In a first step, VIESSMANN will build burner prototypes, consisting of a water-cooled housing with an integrated heat exchanger spiral in a porous medium. INSULCON will provide the ceramic materials for all the PMB-HE prototypes and develop special forms of the ceramics materials, so that combustion, heat exchange and mechanical and thermal stability of the ceramic parts are optimised. A first set of tests will be run for this first prototype, in order to ensure that it provides low-emission combustion (CO < 5ppm, NOx < 5ppm) and high efficiency. Then, detailed radiation heat transfer computations will be carried out at IST-LISBON. Computations using full detailed chemistry will be performed at IC-LONDON to provide the theoretical background for the study of emission characteristics. The combustion control systems will be established by PKO-OSMO. In a second step of the project, the burner design towards a ceramic burner will be improved by all partners. The final stage of the project aims at a burner that has as many ceramic parts as possible and is technically and economically sensible. Expected Achievements and Exploitation Within 18 months, the go
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Geodetic data assimilation: Forecasting Deformation with InSAR'.

assistant: **Objectives**

Recent space-based geodetic measurements of ground deformation suggest a paradigm shift is required in our understanding of the behaviour of active tectonic faults. The classic view of faults classified in two groups – the locked faults prone to generate earthquakes and the creeping faults releasing stress through continuous aseismic slip – is now obscured by more and more studies shedding light on a wide variety of seismic and aseismic slip events of variable duration and size. What physical mechanism controls whether a tectonic fault will generate a dynamic, catastrophic rupture or gently release energy aseismically? Answering such a fundamental question requires a tool for systematic and global detection of all modes of slip along active faults.The launch of the Sentinel 1 constellation is a game changer as it provides, from now on, systematic Radar mapping of all actively deforming regions in the world with a 6-day return period. Such wealth of data represents an opportunity as well as a challenge we need to meet today. In order to expand the detection and characterization of all slip events to a global scale, I will develop a tool based on machine learning procedures merging the detection capabilities of all data types, including Sentinel 1 data, to build time series of ground motion.The first step is the development of a geodetic data assimilation method with forecasting ability toward the first re-analysis of active fault motion and tectonic phenomena. The second step is a validation of the method on three faults, including the well-instrumented San Andreas (USA) and Longitudinal Valley faults (Taiwan) and the North Anatolian Fault (NAF, Turkey). I will deploy a specifically designed GPS network along the NAF to compare with outputs of our method. The third step