RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European integrated hydrogen project' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The main focus of the proposed project is to come to a harmonized approach for the licensing and approval of hydrogen related vehicles, infrastructural equipment and components (e.g. from the EuroQuebec Hydro-Hydrogen Pilot Project [EQHHPPl, and other hydrogen vehicles and infrastructure equipment presently existing or being planned for the very next years). In order to achieve this goal, appropriate risk analysis instruments (e.g. fault tree analysis FTA, failure mode and effects analysis FMEA) for existing hydrogen vehicles and infrastructure equipment shall be worked out creating a more profound and comparable basis for discussion with the licensing authorities. The following activities shall be performed in the project: 1. Survey of existing European rules and regulations for licensing and evaluation of these rules and regulations as a basis for discussion [in Task 1 and Task 2] 2. Identification of rules and regulations already eligible for harmonization [in Task 3] 3. Identification of deficits in licensing practices [in Task 4 and Task 5] 4. Research and safety studies needed as preparation for standardization activities [in Task 4, 5, 6 and 7] (Safety concepts and risk analyses for LH2 and LNG vehicle/ storage systems; Investigation on licensibility of vehicle refueling systems; Safety studies comprising detailed modelling of dispersion, combustion and explosion phenomena in free, semi-confined and confined spaces; Collecting operation experience from past and ongoing projects; R&D leading to minimum certification infrastructure and standard licensing process for compressed gas vehicles, especially H2; Experimental investigation of two-phase flow in an existing safety valve for cryogenic tanks); Investigation on high strength steel tanks and refueling systems; 5
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'from Intrinsic Motivations to Transitional Wearable INtelligent companions for autism spectrum disorder', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The IM-TWIN project aims to develop some of the outcomes of the FET GOAL-Robots project towards market exploitation. The basic-research FET GOAL-Robots project aimed to study how intrinsic motivations (“curiosity”) drive exploration and learning in children, and how such processes can be used to develop innovative autonomous robots. This led to conceive the idea that intrinsic motivations can be used to build engaging interactive robots usable for the treatment of children with developmental disorders, in particular within the Autism Spectrum Disorder (ASD). ASD is a condition with dramatic importance for the well-being of society as it affects about 1 out of 10 newborns in developed countries. We thus developed a “wearable companion robot”, usable for the treatment and daily support of ASD, called PlusMe, now at the stage of prototype. The IM-TWIN project has two sets of objectives. The first is to develop a highly-modular system pivoting on the PlusMe, called the IM-TWIN, addressing the needs of the market segment involving ASD therapy centres and, potentially, families with ASD children: this involves endowing the PlusMe with intelligent behaviour, equipping it with additional embedded biosensors and cameras for detecting the child’s affective/emotional state, and integrating all components as a whole IoT system. The second set of objectives aims to validate the device and its components with target stakeholders, and to carry out a number of activities directed to advance the system components to a higher Technological Readiness Level (TRL7 for the PlusMe): this involves identifying the target groups and analysing ASD-related markets, refining and implementing an effective IPR strategy, planning the steps for individual and collective exploitation of the project outc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cloning and characterization of the genes regulating expression of the avirulence gene avr9 of the fungal tomato pathogen cladosporium fulvum' under Fourth Framework.

assistant: **Concept**

Recent studies with pathogenic bacteria and fungi have shown that several genes are induced when the pathogen grows in planta. The avirulence genes code for race-specific protein elicitors which are inducers of the hypersensitive response in plants with the complementary resistance genes. In order to develop durable resistance crops to pathogens by molecular resistance breeding, a good understanding of the function and regulation of avirulence genes is essential. One of these genes is the avirulence gene Avr9 of Cladosporium fulvum. In this project we will study the regulation of the expression of the Avr9 gene by performing promoter analysis and searching for cis- and trans-activating elements. Mutants will be isolated which show constitutive expression in vitro of this in planta-induced gene. Mutants with alterations in the regulatory genes will be used in complementation studies to isolate positive clones which code for the regulatory proteins.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Reconfigurable OFDMA-based Cooperative NetworKs Enabled by Agile SpecTrum Use'.

assistant: **Innovation**

The project aims at provisioning a ubiquitous wireless solution to reach bit rates higher than 100Mbps with peak throughputs higher than 1Gbps, based on Reconfigurable OFDMA Cooperative Networks enabled by agile spectrum use (ROCKET). While increasing peak rates is a natural must-do for new standards, providing homogeneous high rate coverage is equally important as it guarantees a constant user experience over the whole served area and is the key enabler to a higher average spectral efficiency of the system. Those goals are inline with the IMT-Advanced requirements described in [ITU-R M1645] and match the requirements of the IEEE 802.16 Task Group m (TGm) for Advanced Air Interface.<br/>In order to guarantee a strong focus and efficiency in the project, we propose to limit the scope of our investigations to two questions which we believe will be at the centre of future IMT-advanced system design:1. How can we increase the bandwidth and make the whole system benefit from it?2. How can we increase system spectral efficiency and provide ubiquitous high-rate coverage?<br/>Those questions are addressed by devising methods for improved spectrum usage, advanced multiuser cooperative transmission and ultra-efficient MAC design. Providing inputs to standardization bodies, generating IPR and demonstrating capabilities of some algorithms on a test-bed are the way the project plans to have actual impact.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Adaptation of Pseudomonas aeruginosa to the human host during chronic infections' (PACI) targeting Seventh Framework.

assistant: **Abstract**

Pseudomonas aeruginosa (PA) is an important bacterial pathogen causing a wide range of acute and chronic infections (CI). It usually expresses a yellow-green pigment. It is a major cause of respiratory CI in patients with underlying diseases such as cystic fibrosis (CF) leading to a progressive lung damage. Pathogenesis in CI implies a genetic diversification of PA, with emergence of atypical mutants such as brown pigment producing PA (bpPA). PACI study aims to explore the adaptation process of PA in CI, through the example of bpPA and to evaluate the clinical outcome of the emergence of such mutants. Ten clinical (CF and non-CF) or laboratory bpPA, and their isogenic yellow-green counterparts, have been identified. Preliminary data showed a large deletion in the same chromosomal region in bpPA when compared to their parental strains. Deleted genes are involved in chimiotactism, metabolism, resistance to antibiotics, synthesis of lipopolysaccharides, biofilm formation, anaerobic respiration and regulation. This strongly suggests that bpPA deeply modify their behaviour and virulence strategy in patients. The applicant will identify the deleted genes in bpPA using comparative genomic DNA hybridization microarrays and to assess variations in resistance to antibiotics and pyocins, growth under diverse conditions, metabolism, motility and virulence factor production. He will correlate the emergence of bpPA in CF-patients with disease progression using existing clinical data and bacterial collection. This proposal will permit the fellow, now in position of Associate Professor/Hospital Practitioner in the Dpt of Bacteriology, University of Franche-Comté (Besançon, France), to conduct the project during 2 years in the Dpt of Microbiology, University of Washington (Seattle, USA)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Assessing the Technical and Business Feasibility of Highly-active and Stable Intermetallic Pt-alloy Catalysts for Application in PEMFCs' (StableCat) targeting Horizon 2020.

assistant: **Abstract**

Proton exchange membrane fuel cells (PEMFC) are crucial in the race towards cutting the greenhouse gas emissions – covering 90.7% of total fuel cell market share already in 2018. PEMFCs as a zero-carbon technology converts hydrogen, as a fuel, and oxygen from the air into clean electricity, with water being the only by-product. In doing so, the catalyst material plays a crucial role. Currently, the most promising strategy is to use scarce and expensive platinum (Pt) in the form of carbon-supported nanoparticles (NPs) that are alloyed with a less expensive metal M (e.g. M = Ni, Co or Cu; Pt-M/C). However, current commercial catalyst solutions cannot yet combine the ‘three-pillars’ within the same material – (i) high electrochemically active surface area (ECSA), (ii) high catalytic activity and (iii) high stability. Thus, the StableCat project addresses the pressing need for the improvements of commercial catalysts by obtaining atomic-scale structural understanding. A unique methodological approach developed in project ERC StG 123STABLE resulted in a novel synthesis strategy that, for the first time, combines all three-pillars within the same catalyst material, and will pave the innovative way as an enabler for mass commercialisation of PEMFC technology. Our investigation revealed that 123STABLE catalysts exhibit up to 40% increase in ECSA, a 2-3 fold increase in catalytic activity, as well as an intermetallic crystal structure with increased stability towards corrosion. In addition, the new synthesis approach has also revealed significant potential at reducing the amount of Pt in PEMFCs (50% reduction possible already today). The goal of StableCat is to conduct technical and business activities necessary to enter the commercialisation phase, preferably in a form of a Spi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Novel platform for combinatorial genetic libraries by recombination'.

assistant: **Objectives**

Assembly of combinatorial genetic libraries for identification of biomolecules with novel or improved properties requires high fidelity and efficiency to produce the greatest spectrum of genetically diverse clones. We have been developing homologous recombination (HR) as a platform for the production of combinatorial genetic libraries for affinity maturation and diversification of human therapeutic antibodies. Therapeutic antibodies have a great clinical potential in various therapeutic settings including the treatment of a number of oncology, autoimmune and infectious diseases, organ transplantation, and others. In brief, we describe a method, where CDR-encoding DNA oligos and a gapped vector containing the heavy and light chain genes are cotransformed into budding yeast Saccharomyces cerevisiae for in vivo assembly by HR. Importantly, the affinity of resulting antibody clones in the generated library can be directly assayed by yeast surface display without subcloning and retransformation. Furthermore, mating two haploid yeast strain libraries each encoding a variation of heavy chain or light chain genes enables fast screening of the heavy/light chain combinations displayed by the resulting diploids. Finally, this method can be generalized to generate combinatorial genetic libraries for other applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Regulation of endothelin-1 and mediator release from endothelial cells in culture and a characterisation of the receptor pathways involved' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Endothelin-1 (ET-1), which is synthesised by endothelial cells is the most potent vasoconstrictor and pressor peptide yet described. Increases in the production of ET-1 are associated with a growing list of cardiovascular dysfunctions. Thus, an understanding of the biology of ET-1 may well help in the understanding of many cardiovascular disease processes. Although the effects of exogenous ET-1 on different vascular systems have been partially characterised, the mechanisms involved in the synthesis, release and metabolism of the endogenous ET-1 are poorly understood. This is largely due to the lack of simple to use models in which responses to endogenously produced ET-1 may be investigated. Within the course of the proposed project a multi-disciplined approach will be used to understand how ET-1 is regulated. Thus, isolated cells and vascular preparations in vitro will be used to understand how ET 1 is released and acts, and whole animal experiments will be used to show how individual vascular beds respond to both exogenous and endogenous ET-1. In addition, biochemical assays will be used to measure mediator release and molecular biology to investigate changes at the enzyme level. The information gained from this proposed project will further our understanding on how ET-1 interacts with other endothelial-derived mediators and may well provide the impetus for new approaches in the use of ET-1 receptor antagonists and synthesis inhibitors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'National Communism as intellectual tradition and political program in Czechoslovakia' (NATCOM).

assistant: **Concept**

The project National Communism (NATCOM) addresses the ambivalent and dynamic relations between communist ideology and nationalism. The project goal is to investigate how national communism, in its various stages, shaped the political, intellectual, and cultural development in Czechoslovakia during the “short 20th century”, from 1918 until the second half of the 1990s. National communism, as understood in this project, is a specific variety of communist thinking deeply rooted in the Eastern Central European (ECE) intellectual tradition. It is a crucial phenomenon that both predates and outlives the existence of the socialist dictatorships in the region. The investigation addresses the central question of how the complicated, ever-changing relations between communism and nationalism formed the development of the Czechoslovak socialist dictatorship and how the remodeled national communist agenda after 1989 influenced the post-communist transition. The main objects of the analysis are the nature of communist appeals to national legitimacy and the continuities between national communism and the “national populism” in the 1990s Eastern Central Europe. The research of national communism will look for continuities that survived the implementation of the new rules, the cases of adaptation, and evolution according to specific traditions. The main question is how the intellectual substance of national communism adapted to and also formed the changing reality. National communism will be analyzed with a specific focus on the Slovak part of the Czechoslovak Republic, in its interactions with the Czech and Hungarian environment. However, Slovak development is not understood as unique. NATCOM uses it as a case study identifying and providing distinct developmental traits typical for ot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pre-natal exposure to urban AIR pollution and pre- and post-Natal Brain development' in the context of a Horizon 2020 call.

assistant: **Objectives**

Air pollution is the main urban-related environmental hazard. It appears to affect brain development, although current evidence is inadequate given the lack of studies during the most vulnerable stages of brain development and the lack of brain anatomical structure and regional connectivity data underlying these effects. Of particular interest is the prenatal period, when brain structures are forming and growing, and when the effect of in utero exposure to environmental factors may cause permanent brain injury. I and others have conducted studies focused on effects during school age which could be less profound. I postulate that: pre-natal exposure to urban air pollution during pregnancy impairs foetal and postnatal brain development, mainly by affecting myelination; these effects are at least partially mediated by translocation of airborne particulate matter to the placenta and by placental dysfunction; and prenatal exposure to air pollution impairs post-natal brain development independently of urban context and post-natal exposure to air pollution. I aim to evaluate the effect of pre-natal exposure to urban air pollution on pre- and post-natal brain structure and function by following 900 pregnant women and their neonates with contrasting levels of pre-natal exposure to air pollutants by: i) establishing a new pregnancy cohort and evaluating brain imaging (pre-natal and neo-natal brain structure, connectivity and function), and post-natal motor and cognitive development; ii) measuring total personal exposure and inhaled dose of air pollutants during specific time-windows of gestation, noise, paternal stress and other stressors, using personal samplers and sensors; iii) detecting nanoparticles in placenta and its vascular function; iv) modelling mathematical causality
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'MindSpaces - Art-driven adaptive outdoors and indoors design' under Horizon 2020.

assistant: **Concept**

MindSpaces aims to create a novel approach to urban and architectural design by generating 3D-VR immersive and emotion-adaptive ‘neuro-environments’ that will help in designing emotionally-relevant urban spaces. The emotional aspects of an environment will be captured through the use of mobile EEG (Elecroencephalography) headsets, wearable bracelets/watches, and other physiological sensors that will be embedded with a VR-headset, so as to allow capturing the neuro-feedback of a VR-experience. The neuro-feedback will allow the virtual space to be adapted accordingly, resulting in an emotion-adaptive space. The ‘neuro-environments’ will be used at two levels of granularity. At the first level, artists and creatives will experience the ‘neuro-environments’ with the intention to improve the emotional-relevance of the urban space through the neuro-feedback of individuals, that have very-well developed the perception of aesthetics in what refers to symmetry and harmony but also to unconventional thinking leading to unexpected solutions. At the second level, the ‘neuro-environments’ will be experienced by the potential occupants of the urban space, so as to improve the emotional-relevance of this space through the neuro-feedback of individuals that have developed through experience the perception of space usability, comfort and functionality. This will allow MindSpaces to combine the transversal competencies and unconventional thinking of Artists, with the empirical and pragmatic perception of actual occupants, so as to drive the development of unconventional and unexpected solutions in the design of urban spaces.


**Keywords:** Neuro-architecture, Affective Computing, Digital Art, CAD, CAM software,  Adaptive 3D-models, VR, AR, Immersive Environments, Semantic Reasoning Base