RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Air-cooled, solar (gas) -driven nh3-h2o absorption system for air conditioning and other cooling applications using a compound parabolic collector' under Fifth Framework.

assistant: **Concept**

Air-conditioning is the dominating energy consuming service in buildings in many countries. In many regions in Europe the demand for cooling and dehumidification of indoor air is growing due to increasing cooling loads. Conventional cooling technologies exhibit several clear disadvantages: their operation demands a high energy consumption; they cause high electricity peak loads; they significantly contribute to the Greenhouse effect (induced CO2 emissions resulting from the production of electricity) and they generally employ refrigerants that have several negative environmental impacts (global warming, ozone depletion).This project addresses these problems by development and integration of the necessary technologies for utilisation of solar energy for air conditioning of buildings. The industrial target is to develop and demonstrate a new air-cooled solar-driven NH3-H20 absorption system for air-conditioning and other cooling applications, with a capacity of 10 - 50 kW, using a compound parabolic collector and a gas-driven back-up system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'General Relativistic numerical models of accretion disks and magnetic reconnection with the PLUTO code', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Magnetic fields shape the dynamics of relativistic plasmas that orbit around astrophysical black holes (BHs), as observed in current general relativistic magnetohydrodynamic (GRMHD) models. A primary example is magnetic reconnection, i.e. the rearrangement of the structure of magnetic field lines, which converts magnetic energy into kinetic and thermal energy and accelerates particles to relativistic velocities, thus producing the high-energy non-thermal radiation observed from accreting compact objects. Despite the importance of small-scale instabilities in determining the properties of magnetic dissipation and particle acceleration, global simulations of relativistic accretion disks usually consider either infinitely conducting fluid or one with a constant finite magnetic dissipation, which doesn't capture the collisionless nature of astrophysical plasmas. The goal of the GR-PLUTO project is to perform the first GRMHD numerical study on reconnection in relativistic disks using an effective non-constant resistivity, which will go beyond standard fluid models by introducing new non-collisional effects in global GRMHD simulations. This approach will test our current knowledge of relativistic magnetic reconnection and provide more consistent estimates for the rate at which particles can be accelerated, along with the general structure of magnetized accretion flows around BHs where this process occurs. As the simulations required to quantify the improvements w.r.t. state-of-the-art relativistic MHD reconnection and GRMHD accretion flow models have a high computational cost, the action will include the development of a numerical tool for the modeling of GRMHD flows based on the public PLUTO code. In collaboration with the hosting group at UniTo, the action will produce a ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Death and Life of Catalysts: a Theory-Guided Unified Approach for Non-Critical Metal Catalyst Development'.

assistant: **Innovation**

Most of the developments in catalyst are still based on serendipitous and trial-and-error approaches, in which potential systems can be overlooked simply because of the sub-optimal conditions of the initial activity assessment. Mechanistic and kinetic studies could provide a framework for a more adequate assessment of new catalysts, but such rigorous experiments are not practical for general catalyst discovery. Modern chemical theory and computations hold a promise to be employed in new efficient theory-guided approaches for rational catalyst and process development. The main aim of DeLiCat is to formulate a hierarchical computational strategy for the design and synthesis of new non-critical metal-based catalysts for sustainable chemical transformations. New, durable and cheap, yet, highly active and selective tailor-made catalyst for hydrogenation of carboxylic acids and their esters as well as for acceptorless dehydrogenation of alcohols will be developed. The research will follow an innovative strategy combining advanced chemical theory, computational screening and experimental approaches from the fields of homogeneous and heterogeneous catalysis in an efficient knowledge exchange loop. Computer simulations will reveal complex reaction networks that determine the “death” and the “life” of catalyst systems. These insights will be used in targeted design of novel multifunctional catalyst systems to direct the selectivity of the reaction network and to prevent deactivation paths. Complementary experimental studies will guide and validate the theoretical predictions. DeLiCAT represents a leap forward in unified first principles-guided catalyst design for liquid phase chemical transformations. The new theoretical concepts, methodological advances as well as the novel supe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cellular mechanisms controlling the water permeability of the plant plasma membrane' under Sixth Framework.

assistant: **Concept**

The prominent role of water in the plant life provides the motivation for a number of scientific groups to investigate the role of water channels, aquaporins (AQPs), in the plant water relations. AQPs are present in all the living organisms that have been researched to date. They transport water as well as small neutral solutes across the cell membranes.The understanding of the AQP molecular functionality and structure progressed considerably during the last decade. In spite of that, the mechanism by which the AQP activity is being regulated at the plant cell level is still poorly understood. Our main objectives are to achieve a better understanding of the mechanism controlling the water permeability at the level of a single cell via the regulation of its plasma membrane AQPs, and to correlate this mechanism with the whole plant-water relationship.Two major mechanisms are likely to be involved: gating (conformational changes of the AQPs) and trafficking (shuttling of small vesicles rich in AQPs). Specific AQ P gating models in plants are based mainly on data obtained after plant AQP expression in Xenopus oocytes (e.g. gating behaviour of AtPIP2;2. controlled by the cytosolic pH, of Soybean nodulin 26 controlled by phosphorylation). Trafficking models in plants are based on proteins other than AQPs (e.g. Auxin transporter PINI) or on mammalian AQP2 and AQP4 trafficking models. Identifying similar mechanisms directly involved in the regulation of plant cell water permeability should enable us to achieve these objectives.To this end, we plan to investigate the plant AQP activity using specific chemicals known to affect the cellular concentrations of protons or Ca2+, second messenger ions involved in many regulations processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CommerciaL Energy ARray for Widespread Acceleration of Tidal European Resources' (CLEARWATER).

assistant: **Concept**

Our project consortium will design, build, install and operate an open ocean 4.5MW tidal energy farm in the Inner Sound in the Pentland Firth, off the Northern coast of Scotland. The project (“Clearwater”) will demonstrate the technical and economic feasibility of a multi-turbine tidal energy array, an essential step to catalyse development of commercial projects in the EU ocean energy industry. Project Clearwater provides a credible, robustly implemented transition from high cost single turbine demonstration deployments of marine turbines to economically viable multi-hundred turbine arrays in oceans and managed water assets across Europe and the wider global market.The consortium consists of, and is funded by:UK - Atlantis Operations (UK) Ltd. (“Atlantis”): open ocean tidal turbine technology (including operating the world’s first 1MW grid connected open ocean tidal turbine at the European Marine Energy Centre in Scotland in 2011); Edinburgh University (“UEDIN”): research institution (with significant focus on all aspects of ocean energy, from resource analysis, through to array  modelling and commercialisation research).The Netherlands –Royal Haskoning (“RH”): engineering and environmental consultancy (having secured in excess of 2,000MW of offshore wind consents).Denmark – DHI Water & Environment (“DHI”): world leaders in tidal resource assessment and hydrographical modelling.The project, which will run from 2014-2018, will build on the AR-series open ocean tidal turbine system tested at EMEC to deliver a wide range of new innovations. Most importantly the project will provide a number of step changes that will catalyse the European marine industry:Generating a target of 10,000MWh of clean energy to the European grid; De-risking  environmental consenting process thro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'QUANTum mixtures In FLat And Curved geometries' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Ultracold quantum gases allowed to realize experimentally several paradigmatic models of theoretical physics, such as nonrelativistic bosons and fermions with zero-range interactions. One of the issues driving the last decades of research on quantum gases was understanding how, from these fundamental models, macroscopic structures and quantum phenomena emerge. Along this direction, the most recent advances of the field include the discovery of dilute quantum droplets and supersolidity in gases with long-range interactions. A great deal of experimental and theoretical attention is now directed at identifying novel phases of multi-component Bose or Fermi mixtures with different compositions, different types of interactions, and in various geometries. The QUANTIFLAC project will analyze low-dimensional Bose-Bose and Fermi-Fermi mixtures of ultracold quantum gases, with the goal of engineering minimally-complicated microscopic models displaying exotic many-body effects. We plan to study emergent inhomogeneous structures in bosonic mixtures and self-binding in fermionic mixtures, aiming to determine whether this type of phenomena can be driven exclusively by structureless zero-range interactions. We will also investigate Bose-Bose mixtures confined in various curved geometries, to understand how the interplay of curvature, boundary conditions and topology regulates the macroscopic quantum behavior of the system. This theoretical project has tight connections with various established experimental groups: its results will raise immediate interest and have far-reaching implications for the quantum simulation of matter with ultracold atomic mixtures and for the fundamental understanding of macroscopic quantum aggregates.


**Keywords:** Ultra-cold atomic gases, Few-body physics,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Evicting pathogenic type-2 resident memory T cells from the lungs of asthmatics' (4GETasthma).

assistant: **Innovation**

Asthma is the most common chronic lung disease. In most asthmatics, allergen-specific type-2 CD4 T cells orchestrate allergic airway inflammation by producing type-2 cytokines that ultimately drive asthma pathology. Studies suggest that a subset of long-lived memory Th2 cells that reside in the lung, known as tissue-resident memory Th2 cells (T2RM), play a significant role in driving asthma chronicity and persistence. Therapies aimed at depleting T2RM from the lung represent a novel approach to treating asthma, however factors that regulate the generation and persistence of lung-T2RMs remain poorly understood. I hypothesize that distinct and druggable molecular pathways control lung-T2RM survival and re-activation. This work aims to decipher molecular and cellular mechanisms that regulate the maintenance and re-activation of T2RM within the asthmatic lung niche. The host lab has recently developed a novel TCR transgenic (Tg) mouse line (1DER-CD5), containing a monoclonal population of house dust mite (HDM) specific CD4 T cells with high T2RM differentiation potential, which has been confirmed in preliminary experiments performed since joining the host lab. In WP1, I will perform single cell transcriptomic and proteomic analysis on 1DER-CD5 T cells in the lungs of mice in the memory phases of HDM-induced asthma to predict molecular and cellular networks that regulate lung-T2RM. In WP2, I will utilize targeted spatial transcriptomics, paired with confocal microscopy, to define the lung-T2RM niche and validate molecular and cellular interactions predicted in WP1. In WP3, I will use an in vivo CRISPR-screening approach with Cas9+ 1DER-CD5 T cells to pinpoint key druggable pathways that regulate lung-T2RM survival and re-activation. This work is expected to identify molecula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Screening and Functional Analyses of Photoreceptors in Extremophilic Microbial Communities' under Seventh Framework.

assistant: **Concept**

The High-Altitude Andean Lakes (HAAL) in the South American ""Puna-High Andes” are an almost unexplored ecosystem of shallow lakes at altitudes from 3,000 to 6,000 m above sea level. Although exposed to a broad range of extreme conditions they harbour an abundant microbial biodiversity that thrive in environmental conditions of high resemblance to those present in Earth`s early atmosphere. As part of our team in Argentina I have investigated this wide-ranging diversity by culturable and non-culturable methods:  so far we have assembled a collection of 200 extremophilic strains from shallow waters, sediments, flamingo faeces and even stromatolites (the only modern stromatolite-ecosystem on Earth recorded at such hostile environments!).The HAAL are clearly conditioned by the high intensity of UV irradiation - in addition to further extreme conditions (e.g. hypersalinity, drastic temperature changes, desiccation, high pH). The rich microbial diversity found in these lakes points to the presence of outstandingly active DNA repair systems - topics of  high interest for colleagues worldwide investigating biomass for energy research.  Unfortunately our scientific methods are limited - and thus I would like to use the expertise and excellent equipment at the host institute to investigate extensively the strain resistance mechanisms towards UV. These studies on indigenous extremophiles will provide important information about early life – but clearly are of biotechnological and astrobiology interest too.The research will focus on screening and molecular analyses of blue-light driven enzymatic activities such as photolyases involved in DNA-repairing systems - and in particular from the HAAL stromatolite-ecosystems. Their further overexpression and functional study will lead to th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Consumer Experience Design Model for Mass Customisation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This proposal is an opportunity for a promising academic at the beginning of her career with expertise in user interfaces and user experience to work and train with two internationally recognised centres with expertise in geometric modelling and mass customisation. This collaboration will significantly boost her career progress and will allow her to develop into a mature and professional European Researcher as a leading figure in the subject of mass customisation user experience. It will also establish a long lasting connection between the two Hosts and the Hosts and the Applicant.     In mass customisation (MC) creating a satisfying and engaging experience for the consumer is significant, which has been considered as one of the success factors for MC, especially in terms of increasing consumer loyalty. Nevertheless, a number of effort has been made mainly focusing on the technical and business implementation of MC, very little research considers the consumer interaction and consumer experience in MC environment, even though some of them focused on the menu choice design rather than creating an overall experience of interaction, and some of them investigate consumer experience from the manufacture’s perspective rather than the consumer’s perspective. Given these considerations, this research is designed to identify a framework in terms of positive and negative influences of online MC design on consumer experience; identify strategies for initial functional model for MC design based on previous framework; validate the strategies to further develop the model, and use the model to inform the best practice guidelines to provide the design reference and standards for MC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'TimeLapseReader for Quality Control of Immune Cells used for Cell-Based Therapies' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Cell-based therapy (CBT) for cure of difficult-to-treat cancer types is the most disruptive innovation in personalized medicine. However, patient-specific production of therapeutic immune cells is expensive and associated with remaining risks. In particular, it is known that only actively migrating immune cells are efficient against tumours cells, while inactive therapeutic cells can elicit adverse effects. Yet, there is no quality control (QC) regarding motility of therapeutic cells before patient treatment. The goal of the proposal is to promote an integrated bench-top instrument for reliable assessment of motility parameters in standardized cell culture carriers, i.e. the TimeLapseReader.As leading provider of live cell migration assays ibidi strives to market a complete QC solution based on an automated instrument in combination with ready-to-use QC kits, slides and reagents. The TimeLapseReader will allow robust and reproducible migration tests in manufacturing facilities and set a new standard for QC of immune cell in CBT.In Phase 1 the feasibility study will explore key parameters for QC in the most relevant therapeutic cell types and the best market entry strategy. Objectives include:• Identification of relevant QC parameters for therapeutic cells.• Setting up the business plan including competitor and freedom-to-operate analysis.• Strategy to obtain regulatory approval / CE-Marking for the final device version.Expected impact is eminent as CBT is going to enter the medical market with serval hundred to thousands of patients treated worldwide per year. It is expected, that up to 20% of all cancer patients can be cured with CTB within 10-15 years assuming serval millions QC per year. ibidi will apply for funding to validate QC tests in a Phase 2 proposal. Phase 2