RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Reagentless Electrochemical & Fluorescent Biosensor Formats for Detection of Coeliac Disease Toxic Gluten (Gliadins and Glutenins) in Raw and Processed Foodstuffs' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Coeliac disease is an inflammatory disease of the upper small intestine that affects as much as 1% of the European population and results from gluten ingestion in genetically susceptible individuals. The only treatment for CD is a strict gluten-free diet, with the longer the individual fails to adhere to this diet, the greater the chance of developing malnutrition and other complications.  Thus, the existence of reliable gluten free food is crucial to the well-being of the population.  Current assays available for detection of gluten in food suffer from many drawbacks.  Firstly, there appears increasing knowledge as to the toxicity of particular gluten proteins. Secondly, there is no existing protocol that has been demonstrated to quantitatively extract gluten from both raw and processed foodstuffs and assays based on the use of antibodies are incompatible with the reducing reagents. Fourthly, assays typically used for gluten detection exploit indirect sandwich assays, typically requiring 6-8 hours to complete.  Here we propose to address each of the challenges to develop reagentless biosensors for in-situ detection of gluten in foodstuffs by using aptamers.  Aptamers are getting more and more attention in biosensor area especially because of their superior properties over antibodies. Aptamers will be selected against these identified gluten toxic sequences in buffer conditions akin to that required for gluten extraction and are thus unaffected by the reducing agents present (contrary to the case of antibodies).  Furthermore, aptamers lend themselves to highly flexible assay formats not attainable using antibodies.  In the work proposed here, we intend to take special extraction protocol and selected aptamers and exploit them for use in various reagentless aptasensor fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ready-to-use software suite implementing fully individualized neurofeedback protocols for ADHD remediation in clinical setups' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

We propose to develop a ready-to-use software suite implementing fully individualized neurofeedback protocols for ADHD remediation in clinical setups. These protocols will be tailored to each participant’s initial brain functional connectivity, and will combine fMRI- and EEG-neurofeedback to enhance and restore attentional control. The fMRI-neurofeedback will be driven by three specific functional markers derived from individual participant resting-state fMRI brain patterns, respectively targeting inattention, impulsivity and attentional flexibility. The EEG- neurofeedback will intervene in a second step and will specifically target the connectivity changes induced by the fMRI- neurofeedback. These neurofeedback protocols will be tailored to enhance cognitive functions, decrease ADHD symptoms and improve quality of life. Their innovation potential will rely on the combination of unique features optimizing the neurofeedback to individual participant neurophysiology and to achieving transfer of efficiency from within the protocol to real life. The software suit will allow automated tracking of changes in cognitive function, in brain functional connectivity and associated dynamics, in ADHD clinical scores as well as in quality-of-life self-reports. The project will be organized in four distinct work packages: a test work package, a research work package, a software development work package and an IPR, knowledge transfer and market analysis work package. The entire protocol will be released as an easy-to-install and use software suit, allowing clinical ADHD units having access to an fMRI and to an EEG to implement seamlessly. The outcome will be distributed to beta-testing ADHD clinical units and appropriate knowledge transfer plans will be built to maximize societal impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'EnerTwin: A different approach to micro CHP'.

assistant: **Innovation**

Micro Combined Heat and Power (mCHP) systems are a perfect addition to stabilize the electricity grid in the increased presence of volatile renewable sources. Due to their efficient generation and local use of heat and electricity, their fuel saving- and CO2 reduction potential is tremendous. In spite of great interest of the market and policy-makers, currently available mCHP systems suffer from limited life, high investment and very high maintenance cost, making them too expensive for serious market uptake. MTT solves this problem with the EnerTwin, a mCHP system based on a micro gas turbine. The EnerTwin uses commercial off-the-shelf components resulting in low investment cost. Gas turbines are known for low-maintenance, high power density (small size) and long life. MTT uses automotive turbochargers as key components of the turbine: these are produced in millions and contribute to the low cost and high reliability of the EnerTwin. Gas turbines are inherently insensitive to varying fuel compositions facilitating use of various grades of natural gas. Currently, the EnerTwin is at TLR 7: 19 systems have been deployed in 1st-stage field tests at client locations since mid 2013. Besides the field-trial units, MTT has already sold 500 commercial EnerTwins, which promises an excellent commercial market perspective, while concrete contracts are under negotiation for high volumes for Canadian- and Chinese markets. The main objective of this project is the readiness for commercialisation of the EnerTwin. MTT and its industrial project partners will improve the mCHP to meet future CE and ECO Design requirements. Together with these partners, MTT will work on component and system optimisation for reliability and large-volume manufacturing. Additional field-test units will be dep
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'MIM pores: composition, structure and function'.

assistant: **Objectives**

Mitochondria are double-membrane organelles involved in key biological processes such as metabolism, calcium homeostasis and cell death. A major role of mitochondria in inflammation, a mechanism of innate immunity against tissue damage, has been recently recognized. Due to their proteobacterial origin, certain mitochondrial matrix contents can act as potent immune agonists when exposed to the cytosol. Hence, knowing the dynamics and molecular architecture of the mitochondrial pores mediating the release of these mitochondrial contents is crucial for understanding the role of mitochondria in inflammation.While in apoptosis BAX and BAK proteins form pores at the mitochondrial outer membrane (MOM), the components and mechanisms that regulate the permeabilization of the mitochondrial inner membrane (MIM) remain unknown. MITOPORE aims to unravel the identity, dynamic architecture and regulation of the pores that permeabilize the MIM and to understand how they control mitochondria-driven inflammation. We will reach this goal by building on our expertise in membrane biology and advanced imaging to:1)Identify the mediators and regulators as well as the physical forces controlling MIM pores with complexome profiling and image-based biophysical analysis.2)Define their contribution to anti-mitochondria immunogenicity through activation of intracellular immune receptors and communication with the tissue microenvironment in cellular and in vivo models.3)Determine the assembly dynamics and molecular structure of MIM pores and their regulators by combining single particle and super-resolution imaging and advanced electron microscopies. MITOPORE is expected to provide textbook knowledge about the mitochondrial contribution to inflammation. The established workflows will open new avenue
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'qPCR Microfluidics point-of-care platform for dengue diagnosis' (DENVPOC).

assistant: **Concept**

As a result of Global climate change and fast urbanization, global outbreaks of Dengue (DENV)/ Zika(ZIKV)/Chikungunya(CHIKV) virus have the potential to occur. The most common pathway of these infections in humans is through the female Aedes mosquito vector. DENV is an exanthematous febrile disease with varied clinical manifestations and progressions . Due to similarities in symptoms between DENV and ZIKV and CHIKV, it is difficult to make a differential diagnosis, impeding appropriate, timely medical intervention. Furthermore, cross-reactivity with ZIKV, which was recently related to microcephaly, is a serious issue. In 2016, in Brazil alone, there were 4180 microcephaly cases reported instead of 163 cases, more in line with yearly expected projections , , Thus, the sooner an accurate diagnostic which differentiates DENV from the other manifestations is critical; most especially at the early stages of the infection, to have a reliable diagnosis in pregnant women. In 2016, the OMS emergency committee declared that the outbreaks and the potentially resultant neurological disorders in Brazil were an important international state of emergency in public health, as a result of the associated secondary effects; these diseases became a Global concern. This project allows developing a highly and fast Multiplex qPCR POC platform by using FASTGENE technology with a minimal amount of patient serotype. It would reduce the time of analysis (30 to 90’ for a standard) and costs. Additionally, the sample preprocessing and thermalization will shorten real-time PCR amplification time and will be integrated within the microfluidic systems.  This platform can result in a commercialized product whereupon a main market target would be pregnant women and people living or traveling through/fro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Link and Evangelize the FI-PPP from Europe to the world for the benefit of FI research and innovation and to the European industry business' (FI-LINKS).

assistant: **Innovation**

While several studies recognized Europe as a leader in different research fields and as valid competitor to other world areas in many research fields, the status of affairs as regards commercialization of research results is lacking beyond to benefit European industry and European citizens. In the last three years, for the first time in EU Framework Programmes, Enterprises and Research institutions shared a great investment to move from research to commercial solutions under the umbrella of FI-PPP.<br/>FI-LINKS will support such action focusing on the process of evolving EU Future Internet research to a world-wide champion of Internet innovation. The process will take into account the specific business requirements of both large European industries and SMEs, share the results of the FI-PPP in the EU regional and extra-European context to encourage the adoption of FI-PPP results, and validate the long-term vision of FI-PPP.<br/>To achieve these goals, FI-LINKS will establish a number of worldwide and local links around the FI-PPP to support the research and innovation around the Future Internet. The links will have a two-folds purpose. On the one side FI-LINKS will benchmark the quality of FI-PPP technologies and business models against the equivalent research and innovation schemes in the US, Japan, Canada and the BRICs. On the other side, it will identify new EU and international stakeholder groups, currently not part of the FI-PPP programme, and support the transfer of knowledge and best practices from the FI-PPP towards the larger FI community, through different actions, including the organization of European-level conferences and workshops.The evangelization of FI-PPP to SMEs and web-entrepreneurs in Europe requires the endorsement and collaboration of different act
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identities and modernities in Europe: European and national identity construction programmes and politics, culture, history and religion' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

IME investigates European identities, defined as a wide range of definitions of ‘us, the Europeans’ proposed and acted upon by various actors in and around the current European Union (EU), in particular in nine cases: Bulgaria, Croatia, Finland, France, Germany, Greece, Hungary, Turkey, and the United Kingdom. Drawing from the theory of multiple modernities, the project addresses three major issues regarding European identities: what they are, in what ways they have been formed and what trajectories they may take from now on.  Through a set of nine case studies, IME first investigates the diversity of European identities as it manifests in the nine cases.  It then examines the various ways in which these diverse self-definitions have been formulated and maintained in different societal, cultural and systemic settings and in which they have been interacting with various processes and forces.  It then aims to identify commonalities among diverse European identities in nine countries through a series of thematic comparisons of the cases, in order to provide the basis for grounded projection of possible trajectories European identities may take as the processes of European integration continue.  The project challenges the conventional wisdom about European identities and the teleological implication which lies behind much of the discussions of European identities and aims to offer valuable insights into the contexts in which various policies of identity construction are pursued.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Kids and science' to be submitted under Fifth Framework.

assistant: **Abstract**

Kids and Science (KaS) is aimed at children in the 12-14 year range, before they start making career decisions at school. KaS uses the Internet to prepare them for a week in a Science Village as well as to provide essential continuity after this experience. In the Science Village, each week some hundred of kids from different countries interact with KaS staff and young, enthusiastic scientists from industry in projects and one-to-one discussions. This accompanying measure project will show that the Science Village concept can be considered as 'best practice' in interesting kids in the natural sciences. This proposal describes the work in a one year period needed to demonstrate the web-site, the preparation of the project content for the Science Village, the identification of options for the location of the Village, and the demonstration of this inherently new approach.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'SPARC –Sustainable Parasite Control in Grazing Ruminants'.

assistant: **Objectives**

Ruminant farming is critically important in maintaining the viability of rural communities and ensuring food security. Because grazing ruminants are permanently exposed to helminth parasites, efficient worm control is a requirement to guarantee their health, welfare and productivity. Worm control is largely based on preventive use of anthelmintic drugs, but excessive use of anthelmintics has led to anthelmintic resistance, which has become a global threat for effective parasite control. To mitigate anthelmintic resistance in ruminants, sustainable worm control (SWC) strategies should be adopted.The SPARC Community of Practice of farmers, farm advisors and veterinarians will identify needs, practices, barriers and drivers for adoption of SWC practices, develop a list of good practices for SWC in different production systems and regions and demonstrate them on pilot farms. National and international stakeholder networks will share SWC practices among farmers, across borders and production systems (beef and dairy cattle, meet and milk sheep and goats). Dissemination of experiences and results will be facilitated by a Knowledge Exchange Platform on the SPARC website, hosting testimonies, case studies, videos, practice abstracts and decision support tools, available in local languages. SPARC activities and results will be communicated on social media and in professional journals. Overall, SPARC will initiate a lasting European-wide multi-actor community that develops solutions together  to curb anthelmintic resistance, aiding in the green transition of European agriculture.


**Keywords:** parasites, resistance, network, ruminants, grazing, sustainability, control
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Extension of capabilities for mad experiments at synchrotron infrastructures' (EXMAD).

assistant: **Innovation**

Description:Objectives: The growth of macromolecular crystal structure determination and the increasing number of experiments performed at synchrotron facilities require that more efficient use is made of these infrastructures. Obtaining the phases of the structure factors is a limitation in structure determination second only to obtaining crystals. The multiple-wavelength anomalous dispersion (MAD) and optimised single isomorphous replacement with anomalous signal (SIRAS) techniques offer a general method of overcoming this problem. It is therefore desirable to perform diffraction experiments at energies close to the absorption edges of a wide variety of elements.The objectives of the proposal are:-to make available to the European crystallographic user community the ability to use xenon (Xe) and other elements for MAD or optimised SIRAS experiments at Kand L absorption edges;-to make available standard devices for pressurising crystals under high pressures of Xe and other gases;-to produce a two-dimensional detector appropriate for the recording of diffraction patterns produced with high energy (~40 keV) X-rays. The pixel detector will be based on the use of selenium as a photoconductor;-to develop computer methods and software by which the experimental data measured at these energy extremes can be correctly and optimally processed;-to develop computational methodologies to optimise the quality of the phase information obtained;-to establish whether at high Xe pressures solvent contrast experiments can be carried out that can lead to phases for low angle reflections.Results: The majority of the activities planned for the reporting period have been accomplished, and some are even ahead of the schedule, in particular the development of the prototype detector. Especially
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Oxidative protein folding and pathogenesis of metabolic disorders' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Endoplasmic reticulum (ER) oxidation 1 (ERO1) trasfers disulfide bonds to protein disulfide isomerase (PDI) and is essential for oxidative protein folding in simple eukaryotes such as yeast and worms. Higher eucaryotes have alternative pathways for disulfide bond formation (Zito et al., 2010). Recently we have discovered that the ER localized peroxiredoxin 4 (PRDX4) is able to couple use of hydroperoxides for oxidative protein folding, independently of ERO1 (Zito et al., 2010b). Hydrogen peroxide production is coupled both to nutrient assimilation and to insulin signaling whereas disulfide bond formation is limiting to the production of important signaling molecules such as insulin itself (in nutrient and insulin-responsive beta cells) and adipokines (in insulin responsive adipose tissue). The aim of this proposal is to evaluate, in cultured cells and intact mice, the impact of PRDX4 and ERO1 activity on the biosynthesis and the functional state of insulin and adypokines and consequently on intermediary metabolism.  Recent evidence indicates that disulfide bond formation can be manipulated with chemical probes (Blais et al., 2010). Therefore the proposed study may bring to light novel targets for pharmacological intervention in diabetes and insulin resistance states.