RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'HPC BIG DATA ARTIFICIAL INTELLIGENCE CROSS STACK PLATFORM TOWARDS EXASCALE' (ACROSS) targeting Horizon 2020.

assistant: **Abstract**

Supercomputers have been extensively used to solve complex scientific and engineering problems, boosting the capability to design more efficient systems. The pace at which data are generated by scientific experiments and large simulations (e.g., multiphysics, climate, weather forecast, etc.) poses new challenges in terms of capability of efficiently and effectively analysing massive data sets. Artificial Intelligence, and more specifically Machine Learning (ML) and Deep Learning (DL) recently gained momentum for boosting simulations’ speed. ML/DL techniques are part of simulation processes, used to early detect patterns of interests from less accurate simulation results.  To address these challenges, the ACROSS project will co-design and develop an HPC, BD, and Artificial Intelligence (AI) convergent platform, supporting applications in the Aeronautics, Climate and Weather, and Energy domains. To this end, ACROSS will leverage on next generation of pre-exascale infrastructures, still being ready for exascale systems, and on effective mechanisms to easily describe and manage complex workflows in these three domains. Energy efficiency will be achieved by massive use of specialized hardware accelerators, monitoring running systems and applying smart mechanisms of scheduling jobs. ACROSS will combine traditional HPC techniques with AI (specifically ML/DL) and BD analytic techniques to enhance the application test case outcomes (e.g., improve the existing operational system for global numerical weather prediction, climate simulations, develop an environment for user-defined in-situ data processing, improve and innovate the existing turbine aero design system, speed up the design process, etc.). The performance of ML/DL will be accelerated by using dedicated hardware devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Capacity Building And Raising Awareness In Europe And In Third Countries To Cope With Xylella fastidiosa' to be submitted under Horizon 2020.

assistant: **Abstract**

CURE-FX aims to establish a multidisciplinary research program to answer the urgent need to improve prevention, earlydetection and control of Xylella fastidiosa (Xf). An appropriate approach to this emergency should include a coordination and multidisciplinary interaction between a plurality of competences and it can be facilitated by a more intense exchange and mobility of researchers.The objectives of CURE-FX are: To exchange the scientific capacities and novelties among the European Countries as well as between EU and third countries, in particular sensitive neighbor countries. To strengthen the knowledge and the know-how on Xf in third countries having intense exchange of plant material with Europe. To raise awareness in relation to Xf. These objectives will be acheived through: Strengthen preventive measures by consolidating expertise and awareness of plant health agencies, decision-makers and relevant stakeholders; Analyze Xf-hosts interaction and epidemiology; Develop advanced diagnostic tools for the detection and characterization of Xf and associated vectors; Consolidate innovative approaches for disease prevention, monitoring and control; Improving pest risk analysis, phytosanitary legislations and contingency measures for a safe plant material trade and Integrating with current platforms for adequate communication and dissemination ensuring an effective knowledge transfer among the various actors involved. The proposal involves partners from the following countries: Italy, France, Greece, Spain, Belgium, UK, Egypt, Morocco, Tunisia, Lebanon and Iran. Partner countries selected are differently involved in the study and management of quarantine pests, although each one with a different role, approach and competence. These countries can be divided into two group
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European water management between regulation and competition' (AQUALIBRIUM) under Fifth Framework.

assistant: **Objectives**

AQUALIBRIUM will provide a comparative study of national strategies for public-private partnerships in European water management. By collecting data on the current debate, recently taken initiatives and experiences by textual analysis and expert telephone polls it will deliver a general overview of this issue. Moreover, AQUALIBRIUM will organise the assessment and evaluation of the findings by a workshop assembling water management experts representing politics, administration, industry, consumers, environmental groups and science. This workshop aims to identify, categorise and rank topical issues and knowledge deficits in the field of private sector participation in water management. By this means it will help the efforts of the Commission to allocate subsequent research resources in an effective and efficient way, to develop guidelines for a sustainable water management and to implement such measures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Innovative Education for the BioEconomy'.

assistant: **Concept**

BioBeo is a 2 year, €2M project with 15 partners, bridging theory and practice. Its overall aim is to develop and deploy an education programme to enhance understanding and engagement across society regarding lifestyle, circularity and bioeconomy, using 5 bioeconomy themes: interconnectedness, outdoor learning, forestry, life below water and the food loop. A network committed to promoting the bioeconomy concept will co-create and co-deliver the programme. BioBeo will provide for better coordination between bio-science and education in schools by developing the Circular Economy Science-Society message with a particular focus on circular lifestyle/behaviours, and a governance framework on society-wide engagement in bioeconomy policy. BioBeo will address social issues such as gender bias, disadvantaged youth groups, migrants and members of society with additional needs. We shall 1. increase awareness of environmental, social and economic benefits of sustainable and circular bioeconomy among young people at pre-school, primary and secondary school level 2. identify institutional and cultural barriers 3. develop innovative approaches and digital toolkits for educational and information materials 4. pilot BioBeo education programme reaching 35 schools, 1,000 university students, 1,800 parents/guardians and 100 teachers across Ireland, Belgium, Netherlands and Germany 5. demonstrate a measured increase in engagement of young people and their intention to pursue education and careers in life science, technology and bioeconomy 6. enhance governance of bioeconomy related processes within society by engaging European citizens from young to old in active policy making 7. coordinate communication and dissemination to optimise the reach and visibility to students, teachers, policy ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Serving Life-science Information for the Next Generation'.

assistant: **Concept**

SLING is about Serving Life-science information for the Next Generation.  Its goal is to make sure that advances in European Science are supported by the best possible biomolecular information, and that European scientists are optimally equipped to exploit it.  To do this it makes available a comprehensive range of databases and services from SIB and the EBI, provides extensive, high-quality training in the use of these databases, and carries out R&D necessary to enable the data and services to keep page with changing science.  The activities are designed to support both commercial and academic research throughout Europe, and its training will be delivered in numerous European locations.  The work to ensure the quality of the data will include efforts targeted at information in patent literature through the European Patent Office.  New high-throughout methods such as next-generation DNA sequencing will provide major stimuli for the R&D work of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Magnetic Resonance Guidance of Catheter Based Ablation for Cardiac Arrhythmia' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Atrial fibrillation (AF) is the most important arrhythmia in contemporary cardiology, and despite much progress, remain therapeutic challenges. Invasive electrical studies of the heart are often used in the diagnosis and therapy of arrhythmia. Many forms of arrhythmia can be cured by selective destruction of critical electrical pathways with catheter ablation. A major limitation in studying arrhythmia, however, is the inability to visualize soft tissues, and ablated areas of myocardium during catheter ablation procedures. After performing extensive preliminary work on MRI guided electrophysiology in animal models, the aim of this study is to examine the safety and feasibility of real-time MRI guidance for clinical electrophysiology studies and cardiac ablation procedures using custom made catheters, radiofrequency filters, and a shielded signal acquisition system. The objective is to test the hypothesis that MRI guidance will improve the safety and efficacy of clinical ablation procedures.  Specific Aim 1) To study the determinants of successful ablation in patients undergoing standard fluoroscopy guided ablations. Patients with AF will undergo electrophysiology study and ablation using standard fluoroscopy guidance. Completeness of ablation lines will be assessed by MRI, and correlated with acute and chronic recurrence of AF. The effect of ablation lesions on atrial re-modeling will be assessed at 6 months. This aim will provide insight into determinants of success and complications post ablation. Specific Aim 2) To study real-time MRI guidance of electrophysiologic studies and catheter ablation in patients with AF. This portion of the study will be conducted in participants with symptomatic AF. The primary endpoint will be lack of AF documented by Holter monitoring 6
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The phenotypic and molecular consequences of signaling through Hepatic LRH-1 in mice' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

The orphan nuclear receptor, liver receptor homology-1 (LRH-1), is highly expressed in liver and exocrine pancreas. Although LRH-1 has been shown to be involved in developmental and homeostatic processes, its integrated function remains at present ill-defined. This is in part due to the lack of adequate in vivo mouse models to characterize LRH-1. We propose to elucidate the role of LRH-1 specifically in the liver, by integrating state-of-the-art approaches in mouse genetics, physiology and functional genomic s. The strong genetic, developmental, physiological, and biochemical similarities between mouse and man justifies this approach. As homozygous LRH-1 deficient mice are embryonic lethal, we propose to flox" the LRH-1 allele, enabling the generation of temp orally and spatially controlled, hepatocyte-specific, LRH-1 mutant mice.This approach is particularly relevant in metabolic diseases where the pathology affects multiple organs. Using transcriptional profiling, we will obtain a comprehensive molecular fin gerprint to be correlated with the detailed clinical phenotype, in order to identify the signalling pathways controlled by LRH-1.To complement this mouse model the regulation of LRH-1 activity will also be investigated. LRH-1 is constitutively active and ligands are indispensable for it's basal activity. Consequently, LRH-1 activity may be regulated through phosphorylation. The primary sequence of LRH-1 contains several potential consensus PKA, PKC and MARK phosphorylation sites, and their impact on LRH-1 a ctivity has not been fully elucidated.Through the use of specific kinase inhibitors, site-directed mutagenesis, EMSA and cofactor recruitment assays the regulation of LRH-1 activity by kinases will be established. Thus this proposal will generate a mouse model,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Syntenin-phosphatidic acid interaction in exosome biogenesis and cell-cell communication: a structure-function based approach' under Horizon 2020.

assistant: **Concept**

Cells communicate with their environment in various ways, including by secreting vesicles. Some of these extracellular vesicles originate from endosomes, are loaded with proteins, lipids and RNAs and are called exosomes. Exosomes emerge as important players in physiological cell-cell communication, but also in various systemic diseases. Understanding how cells control the selective incorporation of ‘messages’ in their exosomes is thus essential, and such fundamental new knowledge may allow us to better understand cancer spread for example. Recently syntenin, a small intracellular adaptor protein, was identified as essential for the biogenesis of presumably a distinct class of exosomes that might be important for cancer cell communication and systemic invasion. Based on preliminary work, this study aims to evaluate the role of the membrane lipid phosphatidic acid in the formation of syntenin exosomes, their loading with cargo and their function in intercellular communication. A structure-function based approach is used, allowing if successful to pave the way for rational and innovative drug intervention. The fellowship will offer the applicant the possibility to receive an intensive training in biochemistry, cellular, molecular biology and drug discovery as well as to acquire important secondary skills which will pave the way for his career as an independent researcher.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'MATERNAL EFFECTS: FROM ENVIRONMENT THROUGH TO THE MOLECULAR AND INDIVIDUAL LEVEL, AND BACK TO POPULATION ECOLOGY'.

assistant: **Innovation**

One of the main issues in contemporary ecology is to understand how local and global changes in the environment affect natural populations. Recent investigations show that survival and fecundity are strongly affected by environmental conditions experienced during early life.. In particular, the conditions experienced by mothers and embryonic stages, can affect traits of individuals such as lipid reserves, or the latent ability to cope with thermal and osmotic stress. Therefore, important changes in survival, fecundity and population dynamics could be caused by changes in environmental conditions of the natal habitat, i.e. where the individuals are born as free-living organisms, but also, where adults mate and eggs/embryos develop associated to the mothers. In the marine habitat, climate change is provoking profound modifications of temperature and salinity, thereby affecting habitat conditions. Most marine animals develop through larval stages that disperse away from the natal habitat, but it is vital for the maintenance of populations that these individuals survive and recruit to the juvenile/adult stock. Maternal and embryonic effects on larval traits can be a source of variability in recruitment, thus acting as a conduit for local and global effects on populations. This proposal addresses the issue of the effect of natal habitat conditions on traits, survival and growth of larval stages. The project focuses on a key marine invertebrate, the shore crab Carcinus maenas, a predatory species native to the European coast, but invasive elsewhere. Following a comparative-experimental approach the project will study how egg and larval traits vary across different habitats and how temperature and salinity experienced by embryos affect larval traits, survival and growth. The g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mastering skills in the training Network for attention deficit hyperactivity and autism spectrum Disorders' (MiND).

assistant: **Innovation**

Attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) are frequent, chronic and highly heritable neurodevelopmental disorders. Despite their societal importance, progress in understanding disease biology has been slow and no curative treatment options are available.The pan-European training network MiND aims to educate a new generation of researchers in the field of neurodevelopmental disorders, through innovation-oriented research combined with highly interdisciplinary and intersectoral international training.Research and training in MiND span state-of-the-art topics in the fields of ADHD, ASD and their yet un-investigated overlap. We combine advanced (epi-)genetics approaches with bioinformatics and develop novel cell and animal models of increasing complexity to understand pathomechanisms. Integrated with research in large human DNA-neuroimaging-cognition data sets, we push forward the understanding of the biology leading from gene to cognition and disease. Our mechanistic work is embedded in a framework exploring alternative disease definitions for ADHD and ASD across the lifespan and working towards improved treatment: we use novel cognitive assessments, we probe the microbiome for dietary interventions reducing symptoms and evaluate mindfulness training as non-pharmacological treatment options, in addition to developing new compounds for pharmacological treatment optimization and individualization. The strategic collaboration of world-leading academic groups, research-intensive commercial enterprises and patient organisations will deliver 15 young, scientifically excellent researchers which are optimally prepared for private sector and academic careers.MiND can be expected to impact patients and society by improving our understanding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The reception of ancient Greece in pre-modern French literature and illustrations of manuscripts and printed books (1320-1550): how invented memories shaped the identity of European communities' (1320-1550) under Horizon 2020.

assistant: **Objectives**

Until now the reception history of ancient Greece in pre-modern Western Europe has focussed almost exclusively on the transmission of Greek texts. Yet well before the revival of Greek’s teaching, numerous vernacular works, often illustrated, contained elaborate representations of ancient Greece. AGRELITA will study a large corpus of French-language literary works (historical, fictional, poetic, didactic) produced from 1320 to the 1550s in France and Europe, before the first direct translations from Greek to French, as well as the images of their manuscripts and printed books. It thus aims to challenge one of the great narratives that still prevails in European history: that the revival of interest in ancient Greece only took place through the first direct contacts with Greek works. It will change our perception of the Renaissance. The study of these works and their illustrations (text and image’s dialogue and powers of each) will analyze the representations of ancient Greece from the unexplored perspective of the elaboration of a new memory. It will reveal its structure, its meanings, and the various uses that authors made of it with respect to national, regional or European communities they depicted in their works. It will allow to better understand how, at a time which inherited negative preconceptions about the Greeks, Europe nevertheless began to claim ancient Greece as one of its legacies; and lead to a reassessment of the role played by Greece in Western European identities shaping processes. This promises considerable advances in our understanding of the new representations of these communities in this period. AGRELITA also aims to contribute to a general reflexion on the formation of heritages and identities. Its results will provide new insights on our percepti