RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Optimisation of the biotechnological recycling solution for olive washing water' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

The ALGATEC II project is a demostration activity based on the promissing results fo the FP7-SME-2008 ALGATEC project (contract n. 232331). During the ALGATEC project, both the lab and field-scale experiments proved that the system was efficient in removing the pollution load of olive mill washing water (WW) and producing water of drinking quality, that could be reused in the process. However, under the current market status in the main olive oil producing countries, the cost of this technology seemed to be quite high to be implemented in a commercial product. The innovative and easy to operate and maintain system developed, based on; a pre-treatment, a photobioreactor (PBR), and two different configurations of membrane modules, was tested using WW stored in an evaporation pond. For treating this WW, more concentrated than the fresh WW, hydraulic retention times (HRT) of 3 days were needed, and this fact increased the final price of the m3 of treated WW. The decreasing of the HRT together with other potential improvements already identified  to increase the system efficiency and make it more competitive in the market, are the driven force of the proposed project. 5 European SMEs, from 3 EU countries, 4 partners of the ALGATEC project, together with a new SME especialised in market studies, will work in the optimisation of the system by implementing improvements in the pilot plant located in Spain) to increase the treatment capacity working with fresh WW and better conditions with regards to light, temperature and materials for the PBR, optimising the membrane module by replacing expensive materials, re-designing it, and improving the energy efficency. The control system for both, PBR and membranes, would be optimised to decrease, among others, the labour costs associate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Edge-based mechanisms coordinating cell wall assembly during plant morphogenesis' to be submitted under Horizon 2020.

assistant: **Abstract**

A fundamental question in biology is how multicellular organisms robustly produce organ shapes. The underlying process of morphogenesis involves the integration of biochemical, genetic, and mechanical factors across multiple spatio-temporal scales. In plants, morphogenesis is dominated by the rigid cell wall, which fixes cells in their position. Adjacent cells must therefore coordinate their growth patterns, which are in turn controlled by the mechanical properties of the cell wall. Cell walls are assembled by a complex intracellular trafficking machinery that delivers cell wall components and their associated biosynthetic machinery to different subcellular regions. Based on our recent discovery that a trafficking route directed to cell edges is essential for cell wall assembly and directional growth at the cell and organ scale, we propose that morphogenesis is controlled by a signalling module at cell edges which integrates feedback from the cell wall. This hypothesis provides a mechanistic explanation for the integration of cell and tissue-level mechanical factors into coordinated cell wall assembly. We propose that a receptor-like protein recently identified as the first known cargo of edge-directed trafficking acts as a core component of a cell wall signalling pathway at edges. This proposal aims to test our hypothesis through a combination of experimental and computational methods: (1) at the molecular level, we will identify further components of the signalling module through ligand screening, comparative proteomics, and forward genetics; (2) at the cellular level, we will functionally characterise trafficking pathways and their regulation by edge signalling through quantitative imaging, glycomics, and computational mechanics; and (3) at the organ level, we will d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Panda Guide'.

assistant: **Innovation**

Visual impairment entails various risks making people experiencing difficulties leaving the security of their homes which results in vicious circles. Sight loss is linked to increased risk of depression, reduced quality of life, declining physical health, decreased mobility, higher rates of poverty than in the general population. Visually impaired people face various challenges in their daily lives ranging from navigation outside well-known environments, engaging relationships, practicing a profession or even accessing modern technology mainly based on touchscreens.ESTHESIX was officially founded in 02/2017 by a complementary team experienced in entrepreneurship, AI and electronical engineering. We believe everyone deserves to see and therefore we are developing a ground-breaking wearable technology called “PANDA Guide” which will allow all visually impaired (partially sighted people + blind people) to navigate, to socialize and to engage in all daily life activities.PANDA will disrupt the market by offering a multifunctional device that not only provides navigation guidance, but help to learn, earn a living, socialize and have fun. PANDA is multifunctional headset to be placed around the neck with a discreet earpiece. The camera captures the surrounding environment in full 3D and images are converted into intuitive sounds (abstract sounds and semantic speech) transmitted via bone conduction. Our headset has already been validated by over 200 visually impaired people. PANDA is a medical device fully open to the development of third-party software which will have the opportunity to imagine various new uses for our headset.SME Instrument will allow to rise up expectations to have visually impaired people live better, think wider and achieve further. PANDA will provide evi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sexual Commitment of Malaria Parasites: Investigation Into the Epigenetic Control of Plasmodium Gametocytogenesis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Malaria is one of the major threats for human health worldwide and caused by unicellular organisms of the Plasmodium genus. Within their mosquito vector and human host malaria parasites replicate almost exclusively asexually. In order to be transmitted to mosquitoes formerly asexual parasites instead develop into gametocytes, which are the only forms that can infect mosquitoes. Understanding the switch of asexual to sexual replication could offer new routes towards therapeutic intervention in sexual development and transmission. However, the molecular details of commitment to gametocytogenesis remain largely unknown, and only recently the AP2-G transcription factor was identified as master regulator of gametocytogenesis.Gametocyte formation is a dead end for enduring infection and therefore sexual commitment has to be suitably regulated to ensure prolonged infection and transmission at the same time. The proposed research project aims to elucidate the epigenetic mechanisms which controls gametocytogenesis in malaria parasites infectious to rodents and humans, and intends to identify key molecular factors which regulate repression and activation of the ap2-g locus. The project will shed new light on the molecular mechanisms controlling sexual commitment and general gene expression in Plasmodium, with implications for therapeutic intervention in transmission and development of malaria parasites.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enzyme-conjugated DNA nanoswitches for biosensing applications', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

WHY: Diagnostic markers detection plays a crucial role in the diagnosis of human disorders. Unfortunately, however, current methods routinely used for the detection of these biomarkers still require sophisticated equipment, washing intensive, reagent-intensive multi-step processes. In attempt to overcome the cited limitations, the development of platforms supporting the sensitive, specific, rapid and easy to use measurement for several diagnostic biomarkers, directly in real samples, is urgently needed.WHAT: ENZYME-SWITCHES is a multidisciplinary and interdisciplinary programme with the principal aim to develop a new generation of enzyme-based biosensors that could prove transformative for diagnostic applications. To achieve this goal, I will join the high specificity and sensitivity of enzymes, and the high programmability and versatility of synthetic responsive DNA nanodevices to develop DNA-conjugated enzymes able to provide sensitive detection of a wide range of diagnostic markers.HOW: This challenging objective will be reached thanks to the multidisciplinary and complementary approach of the outgoing and incoming research groups. I will join the expertise of Prof. Plaxco (outgoing supervisor) in molecular biology, enzymes, biosensor technology, bioengineering device and biophysic with that of Prof. Ricci (incoming supervisor) in the DNA-Nanotechnology field, analytical chemistry and electrochemistry to optimize the proposed new biosensors platform.I have already a promising research profile demonstrated by a strong publication track-record, by several awards received and by fruitful international mobility. Thanks to this MSC Fellowship, I will further strengthen my CV and diversify my scientific knowledge acquiring cutting-edge competences as well as complementary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular Analytical Robotics Assays' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Diagnostic tests are essential to provide a targeted treatment of infectious diseases and to contain the further spread of multidrug resistant pathogens. Current methods are based either on cultivation or on PCR and have significant limitations concerning the clinical requirements to characterise pathogens including their resistance mechanisms within 3 hours. In MARA, we will develop and combine three radically novel technologies that will lead to substantial breakthroughs in science, medicine and industry and, as proof-of principle, use them to create a DNA-based molecular toolkit characterising pathogens. First, the detection of pathogen-associated antigens will be performed by Autonomous Detection Nucleic Acids (AUDENA) that are independent of any laboratory instruments and sophisticated processing. The realisation of the AUDENA concept will lead to an autonomous, stable, simple and very economic novel sensor class applicable for any water-soluble substances. The second revolutionary technology in MARA employs a novel approach in protein mimicry and creation of artificial enzymes, which represents a breakthrough in several disciplines, such as biotechnology, biomedical manufacturing and the energy sector. The third breakthrough in this project represents the development of a Molecular Robot (MORO) that can specifically identify target cells and destroy them. In MARA, the MORO will be used for the lysis of bacterial cells to release intracellular antibiotic resistance associated antigens, but the long-term vision anticipates an application as antibiotic replacement for infectious diseases and a therapeutic agent for cancer treatment, which would represent one of the most important breakthroughs in medicine in the recent years. To meet the highly ambitious objectives p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Informatics approaches for the rational selection of personalized cancer drug combinations' (DrugComb).

assistant: **Concept**

Making cancer treatment more personalized and effective is one of the grand challenges in our health care system. However, many drugs have entered clinical trials but so far showed limited efficacy or induced rapid development of resistance. We critically need multi-targeted drug combinations, which shall selectively inhibit the cancer cells and block the emergence of drug resistance. This project will develop mathematical and computational tools to identify drug combinations that can be used to provide personalized and more effective therapeutic strategies that may prevent acquired resistance. Utilizing molecular profiling and pharmacological screening data from patient-derived leukaemia and ovarian cancer samples, I will develop model-based clustering methods for identification of patient subgroups that are differentially responsive to first-line chemotherapy. For patients resistant to chemotherapy, I will develop network modelling approaches to predict the most potential drug combinations by understanding the underlying drug target interactions. The drug combination prediction will be made for each patient and will be validated using a preclinical drug testing platform on patient samples. I will explore the drug combination screen data to identify significant synergy at the therapeutically relevant doses. The drug combination hits will be mapped into signalling networks to infer their mechanisms. Drug combinations with selective efficacy in individual patient samples or in sample subgroups will be further translated into in treatment options by clinical collaborators. This will lead to novel and personalized strategies to treat cancer patients.


**Keywords:** Drug combinations, Personalized cancer medicine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modular Igcc concepts for in-refinery energy and hydrogen supply' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Developing advanced modular highly efficient in-refinery energy and hydrogen supply systems.- Production of hydrogen, power, process heat and other chemicals from residues, biomass and low-grade fossil fuels.- Sustainable pollution control by enhanced total plant efficiency and extensive CO2 reduction, saving resources by substituting high-grade fossil fuels.- Preparing modular concepts to ensure a flexible and wide range of application fields.- Securing and expanding employment in the European power and refinery industry through progress in technology and, thereby, improving Europe's export opportunities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ASSESSMENT OF THE SAFETY OF LABAS IN ASTHMA IN ROUTINE CARE BY COMBINING HEALTH-CARE DATABASES AND DIRECT PATIENT FOLLOW-UP' (ASTRO-LAB).

assistant: **Concept**

Background: The efficacy of long-acting β-agonists (LABAs) in asthma has been demonstrated but their safety remains an issue, particularly in children. Co-therapy with inhaled corticosteroids (ICs) is recommended in persistent asthma. However, drug-use studies suggest frequently inadequate IC adherence, possibly explaining the occurrence of exacerbations. There is a need for detailed analyses of patterns of use of LABAs and ICs to describe asthma outcomes related to LABAs in monotherapy and at different levels of concomitant ICs, to explore the role of adherence in LABA safety, and to identify populations possibly at risk of adverse LABA-related asthma outcomes.Methods: Summarise available evidence on the risks of LABAs in asthma; develop questionnaires and instruments for the study; identify, in the UK and France, paediatric (6-15) and adult (16-40) patients with persistent asthma treated by LABAs; and link distinct datasets for this group using past and ongoing prescriptions provided by GPs and identified from electronic health records, dispensed therapy identified from claims data, information collected from prescribers, and details on exposures and outcomes collected by computer-assisted telephone interviews with patients over a prospective 24-month period. Analyze the linked datasets to characterise individual asthma care in detail and with high validity, describe patterns of use of LABAs and ICs, and relate these patterns to asthma outcomes. Disseminate results to the scientific community, patients’ associations, physician’s associations, and regulators.Deliverables: Ranking of observed patterns of LABA and IC use according to risk of adverse outcomes due to LABAs. Identification from prescriber and patient data of predictors of patterns of use which put patients
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Workshop on ganoderma diseases of perennial crops' (WOGADI).

assistant: **Innovation**

The fungus Ganoderma causes a number of diseases of tropical perennial crops and Ganoderma stem rot of oil palm is the single major disease constraint to oil palm production in Asia and Oceania. There have been considerable advances in research for the control of Ganoderma diseases in the last 3 years, particularly in the fields of disease recognition and surveys, epidemiology and bio control. These advances are of particular importance to the development of planting, sanitation and breeding programmes. An International workshop is planned to enable dissemination of the research advances among researchers and stakeholders from both the Asia Pacific region and Europe. The workshop will be held in North Sumatra to ensure availability to relevant workers in the region, and the proceedings will be published in order ensure their free distribution. The workshop will provide a forum for the exchange of information, and the establishment of a collaborative regional research network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The European knowledge space' (KB20).

assistant: **Concept**

Background.KnowledgeBoard 2.0 is a further development of the European KM Forum project IST-1999-26393, where a European KM community consisting of more than 5,000 individuals and 200 corporate members was founded. A major result was the web portal named KnowledgeBoard.Objectives.The goals for KnowledgeBoard 2.0 are to activate and facilitate the European KM community, to further develop it by covering all schools of thought in KM, to extend it to those European regions less well represented today, as well as to other global regions, and to turn the existing KnowledgeBoard into a model and reference for virtual networks offering customised services, collaboration spaces, and a support infrastructure to European research projects, industrial players and other interested parties.Work plan.WP1 develops the technical infrastructure. WP2 provides editorial services to the community as well as customer service and newsletter editing. WP3 facilitates this community and keeps it open and active. WP4 comprises all marketing and business development activities.Project Management.A Steering Group is set up with representatives of all stakeholders involved. This group will consist of the project coordination team, leading KM experts and representatives from the European projects, who collectively define the strategic directions to be taken. The project coordination team turns these directions into operative goals and collaborates with a team of functional leaders who are responsible for the different tasks.Impact.KnowledgeBoard 2.0 will become a model for value creation for virtual research networks, a competence centre for multidisciplinary approaches to knowledge management and the preferred European Knowledge Space for KM research. The project will support the European Commissio