RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Identification of mycobacterial antigens as candidates for a subunit vaccine against tuberculosis in healthy and HIV infected individuals' (1994-1998).

assistant: **Concept**

-To produce large standardized quantities of mycobacterial antigenic fractions.-To identify and clone new mycobacterial antigens and test them as antimycobacterial subunit vaccines in the mouse.-To determine the response of defined human lymphocyte subsets from healthy and tuberculous patients with or without AIDS. -To characterize carbohydrate antigens for NK or xdelta+ T cells and their receptors. -To test the efficacy of a new diagnostic method on urine from adults with mycobacterial infection.Tuberculosis is a global health problem which causes 3 million deaths yearly. The available vaccine, Mycobacterium bovis bacillus Calmette-Guérin, is of questionable efficacy, therefore the development of a subunit vaccine is needed. The project proposed aims at identifying immunodominant antigens as candidate components of such a vaccine. Sets of mycobacterial proteins produced in vitro (membrane, cytosol, cell wall and secretory fractions) and intracellularly, will be isolated and studied for their ability to induce proliferation of human immune lymphocytes in vitro and/or release of cytokines. The recombinant antigens will be tested as to whether they induce an immune status against M. tuberculosis in mice. Moreover, the response of peripheral blood mononuclear cells from human subjects (BCG-vaccinated or unvaccinated PPD+, PPD-, HIV+ and HIV- tuberculous individuals) will be analyzed to assess whether xbeta+, xdelta+ T cells or natural killer cells are mostly responsible for proliferation to the antigen fractions of choice or to cloned proteins and to determine whether any carbohydrate antigen accounts for proliferation of natural killer or xdelta+ T cells. A new method based on detection of lipoarabinomannan in urine will be evaluated for the diagnosis of mycobacterial inf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cooperative Archive of Serials and Articles', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Serial handling and information about the location of serial titles is central to many library services. Project CASA will address both the needs of professional users, such as bibliographic agencies, libraries and journal publishers, to check, verify or revise bibliographic records of serials at the national and international ISSN level; and of end-users searching for serials titles and their locations.The project aims to create a serials authority list based on the ISSN system, allowing users to search distributed catalogues of national serials holdings and to locate serials, while offering national union catalogues and SSN agencies the possibility of exchanging and revising bibliographic serials data in cooperation with the ISSN international centre.The value-added service of CASA should allow the user to find additional information about publishers, document delivery services and article citations and abstracts from multiple locations.Technical approachCASA aims to use client-server architecture and explores possible uses of WWW technology to locate serial services via ISSN. Based on comprehensive surveys of readily available software and commonly accepted standards, it will develop a common user interface for searching the distributed serials catalogues, taking into account in particular Z39.50 for retrieval and existing software development tools such as Java, JDBC, XML, Dublin Core.Key issuesThe project will address the following key issues:the facility for national agencies and libraries to enter, verify and amend serials data according to standardised protocols and software at national level and with the ISSN central register;the ability to search via a common user interface distributed union catalogues of serials;the creation of a Serial Services Directory for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Regulating the immune regulators: targeting adaptive immune control'.

assistant: **Innovation**

The immune system with its complex interactions of cells and molecules needs a very tight and specific interplay of control elements to ensure the establishment and re-establishment of immune homeostasis after challenges. Regulatory T cells (Tregs) are key-players in this regulatory network. It is now well accepted that deficiency or dysfunction of Tregs causes various severe immune disorders due to immune hyperactivation. Conversely, an increased number of Tregs in tumor-bearing individuals suppresses efficient anti-tumor immunity and, thereby, is often associated with poor prognosis. Cancer immunology is now one of the most exciting and promising frontiers in cancer research, and recent clinical trials have proven that immunotherapies driving to activate T cells can induce durable responses. In this sense, harnessing the potential of Tregs is one of the most promising new approaches to control immune function and to treat cancer. This proposal has two objectives: 1, the identification and characterization of tissue-resident Tregs to principally understand the unique features of Treg specialization in tissues and their function in organ-homeostasis, a phenomenon that is hardly understood, but holds great promise for local, tissue-specific immune intervention. 2, to globally target Tregs, including the lymphoid organ Treg pool, by interfering with their survival and or suppression function. We expect from these studies new basic insights into a fascinating and still arcane aspect of organ-homeostasis as maintained by Tregs, as well as novel small molecule inhibitors and candidate molecules that target Tregs at the systemic level, and eventually at a tissue-specific level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'GYNODICY: gender-egalitarian fictions of origin in European philosophical culture (1673-1751)' (1673-1751) targeting Horizon Europe.

assistant: **Abstract**

This project aims at producing the first comprehensive study of the philosophical problem of “gynodicy”, i.e., the incompatibility of, on one hand, a rational defence of women as naturally equal in capacities and in rights to men and, on the other, their factual subjection to men. GYNODICY concentrates on gender-egalitarian texts from the early modern period that circulated within European philosophical culture and specifically on the gender-egalitarian fictions of origin these texts put forth with the objective of arguing against the naturalisation of women’s submission to men. This study is important because the authors of said sources developed the intellectual foundations of the defence of the “equality of the sexes”, which lead to women’s civic and political enfranchisement. These writings on gynodicy have been generally overlooked in academic research, thus contributing to consolidate an incomplete panorama of early modern political thought. GYNODICY seeks to counter this by proposing a new narrative that recovers a body of literature comprised of both printed works and unedited manuscripts, which has hitherto received scanty attention. The project promotes a transnational approach to the circulation of gender-egalitarian ideas and an interdisciplinary perspective. Natalia Zorrilla’s experience studying fictions of origin in clandestine philosophical literature and early modern women philosophers make her the ideal researcher for this project. She will benefit from the expertise of her supervisors: Marguerite Deslauriers (McGill University, outgoing phase) and Marco Sgarbi (Ca’ Foscari University of Venice, return phase). Thanks to the training planned during this GF, Zorrilla will acquire new skills and establish an international scientific network connecting Eur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cancer Organoids Multiplexed Screening in Microfluidic Textile chips' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The development of precision and personalized medicine, notably in cancer, leads to an explosion in the cost of research, clinical trials, diagnosis and treatment. It calls for a change of paradigm in cell-based personalized models, allowing-high throughput screening of large panels of drugs at low cost and on minute samples.  We invented in ERCadg CellO a new technology “Free-Flow Textile Chips” (FFTC) proving a solution to the above problem. It allows the production of high-resolution complex microfluidic devices at very low cost using the power of the textile industry. Using this technology we developed an automated platform able to generate, from a single micro-biopsy, a large number of 3D tumor cell spheroids encapsulated within individual  nanoliter droplets, and to screen them against tens of drug combinations. This platform will reduce the time, sample size, cost of screening  and drugs consumption per assay by factors ranging from 10 to  1000. This will in turn replace animal testing, and allow low-cost high-content drug screening and affordable precision medicine.  This new platform will be tested versus conventional techniques in a real world context, and steps towards industrialization will be taken. We shall first target the market of research laboratories and drug development in the pharmaceutical industry, but also prepare clinical applications to the personalization of anticancer treatments. Beyond this, FFTC represents a major breakthrough in microfluidics, a technological field that is currently revolutionizing biology and medicine. Currently its democratization and societal impact are limited by fabrication costs. FFTC will overcome this barrier. COMMiT  will thus pave the route to a wide range of other applications, such as  “point-of-care” devices o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New insights into the genetic mechanisms underlying behavioural variation in wild marine fish' under Horizon 2020.

assistant: **Concept**

Humans depend on great measure on the welfare of marine ecosystems, not only from the retribution obtained directly from resource harvesting but also from the benefits derived from healthy ecosystems (i.e. quality of natural resources, biodiversity maintenance, and ecosystem resilience to anthropogenic challenges). Traditionally, management efforts to preserve marine resources only contemplated morphological traits of the individuals (e.g. body size). However, more evidence is piling up on the importance of behaviour on biodiversity conservation. Traits such as exploration, boldness, and activity have a strong impact on the individual`s reproductive success, thus determining species survival. As other phenotypical traits, fish behaviour is determined in great measure by its genetic basis. In this project, we propose studying the genetic mechanisms underlying fish behavioural types. We will use a unique dataset based on state-of-the-art fish-tracking data that provides long-term behavioural data in situ for hundreds of free-living fish at unprecedented spatio-temporal resolution. We will complement the behavioural data set with advanced genetic and genomic techniques to find phenotype-genotype associations by: i) studying the sequence variants of candidate genes, ii) studying the location and abundance of target proteins in fish brain structures, iii) obtaining multiple brain transcriptomes from individuals showing distinct behavioural types. The multidisciplinary nature of the project, combining novel behavioural data collection with next generation genomic techniques, will provide a broad overview of the molecular basis of behavioural characterization. The proposed activities will open a new line of research in behavioural molecular ecology unprecedented in marine ecos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Chemogenetics Application and PhotoActivated ChemoTherapy to study Multidrug Resistance in Glioblastoma' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Cancer therapy faces significant challenges due to multidrug resistance (MDR), which reduces the effectiveness of chemotherapeutic agents. A key factor influencing MDR is the altered redox state within cancer cells, characterized by varying levels of reactive oxygen species (ROS). Understanding the dynamics of ROS is crucial, as they can both promote and inhibit tumor progression. Glioblastoma, a highly aggressive and treatment-resistant brain cancer, exemplifies the challenges associated with MDR, often exacerbated by a hypoxic tumor microenvironment and elevated ROS production. This project aims to investigate the role of ROS in MDR by integrating PhotoActivated ChemoTherapy (PACT) and recombinant D-amino acid oxidase (DAAO), a chemogenetic tool that is able to generate hydrogen peroxide (H2O2), the most stable ROS, within specific cellular compartments. PACT is an innovative anticancer treatment utilizing ruthenium-based (Ru) compounds that are selectively activated by red light in an O2-independent manner, minimizing damage to healthy tissues.In this project, I will implement DAAO to introduce controlled levels of H2O2 into glioblastoma cells, and then treat the cells with PACT, targeting NAMPT, a protein involved in the recycling of NAD+. I will correlate cancer cell resistance to PACT treatment with ROS levels, which will be monitored via Genetically Encoded Fluorescent Indicators (GEFIs). The project includes i) developing targeted ROS generation systems during a secondment at the nearby hospital, ii) exploring cellular adaptive responses, and iii) conducting in vivo mouse studies to validate the results from in vitro experiments. This project aims to combine chemogenetic applications and PACT for the first time. This innovative research has the potential to prov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Polygon scanner based ultra-short pulse laser processing in roll-to-roll manufacturing' (PoLaRoll) targeting Horizon 2020.

assistant: **Abstract**

Roll-to-roll manufacturing is well established in many segments like electronics, micro manufacturing or solar technology. Continuous roll-to-roll manufacturing processes can be integrated with various manufacturing steps within the production line. While many conventional and laser manufacturing techniques could already be embedded successfully into roll-to-roll machines, pulsed laser structuring could not be adapted sufficiently. The main obstacles are insufficient pulse repetition rate levels with required pulse energy and beam deflection speed and accuracy. The PoLaRoll project aim is to bring together current developments and fully integrate a high speed ultra-short pulse laser ablation process into a roll-to-roll machine fulfilling the requirements of individualised laser-based mass production. Various disciplines are in focus of the PoLaRoll project:A femtosecond laser will be developed with high pulse energy at extremely high pulse rates. Innovative polygon scanner technology for ultra-fast beam deflection is advanced in speed and accuracy and a dual polygon scanner will be developed enabling simultaneous laser structuring of top and bottom face of web material. An in-line metrology method will be developed enabling process monitoring and control. Highly sophisticated methods will be developed and applied enabling the synchronisation of the ground-breaking ultra-fast processing sub-systems.To prove the PoLaRoll process performance a target application has been selected, which is solar shading of glass facades. The laser formed micro structure's geometry allows cutting the solar radiation and therefore reduces the energy used for cooling and ventilation. The PoLaRoll laser structuring module will be integrated into a prototypical modular designed roll-to-roll mac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The STE(A)M Education European Roadmap' to be submitted under Horizon Europe.

assistant: **Abstract**

The SEER - The STE(A)M Education European Roadmap, is an improvement journey with different stages associated to intervention steps based on research and proven experiences with recommendations, to get more STE(A)M-happy motivated and connected citizens. The SEER will be at the intersection of four major dimensions: (1) the need to collect all that currently is in place (such as STE(A)M education policies, innovative STE(A)M teaching practices, and feedback on how existing STE(A)M programs were implemented so far), (2) the importance to foster exchange and dialogue among all STEAM education stakeholders, (3) the necessity to permanently carry out needs analysis activities that would identify gaps, as well as impact analysis of initiatives and policies and (4) provide guidance for future actions and get the buy-in of citizens and particularly major stakeholders (Ministries, schools, parents, teachers) through outreach mechanisms. The SEER will deliver: a) The SEER process: including focus groups, seminars and case studies with supporting surveys, polls, and results, leading to the identification of gaps and the STE(A)M Education European Roadmap; b) The STE(A)M Education European Roadmap: The Atlas of roadmaps that will help improve STE(A)M Education from different stakeholders starting point and using a myriad of paths depending on the goal to achieve; c) The STE(A)M Education European Roadmap Impact Strategy providing a standard impact assessment mechanism for new STEM plans, projects, and initiatives; d) A proposal of how an Integrated STE(A)M education certification framework could contribute to educational reform, why it is relevant for students, teachers, citizens and MoEs, and how schools can self-evaluate. Additionally, to continuously engage the community at lar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'An integrated approach towards drug discovery and target validation for pain' to be submitted under Seventh Framework.

assistant: **Abstract**

Chronic and neuropathic pain, usually diagnosed as spontaneous pain, hypersensitivity to pain or both, is a maladaptive response of the organism to injury and inflammation.Finding new effective drugs to treat these debilitating conditions has shown particularly difficult, as compounds showing good efficacy in preclinical models often fail to meet clinical trials endpoints. A commonly accepted explanation for this discrepancy is that virtually all preclinical analgesic tests have only limited predictability, as they are based on models of evoked pain, whereas patients mainly seek relief of spontaneous pain.To fill the gap in our knowledge of the mechanism of spontaneous pain and to accelerate the discovery process towards better analgesics, we propose to implement a new in vivo platform for deciphering pain pathways in animal models of spontaneous pain. A new electrophysiological approach, high throughput microneurography (HT-MNG) will be implemented by using in house nanotechnology and microelectronics. This approach will be combined with in vivo RNA interference and optogenetics and validated by specifically addressing targets known to be involved in chronic and neuropathic pain conditions.The proposed preclinical in vivo platform has a great translational potential, as HT-MNG recordings from animal models will provide data directly comparable to those from human patients. Thus, we expect our project to significantly contribute in avoiding expensive failures in Phase II and Phase III pain studies due to lack of drug efficacy. Moreover, by opening the possibility to measure and recognize specific excitability patterns in peripheral neuropathies, the project can help identify patients more likely to respond to a particular drug, dose or regime, thus opening new opportuni