RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Membrane proteins in nanometric holes: Real-time monitoring of membrane-mediated reactions by localized surface plasmons' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Cells are highly compartmented by biological membranes. Besides their function as boundaries between organelles, membranes are complex reaction centers with specialized biochemical functions. Although lipid bilayers provide the basic structure of membranes, membrane proteins are responsible for their functional properties. In fact, 25 % of all proteins encoded in the human genome are membrane bound and about 50 % of all current molecular drug targets are located on membranes. Despite their outstanding importance, many membrane proteins have eluded functional and structural characterization due to analytical challenges. We propose to fabricate a localized surface plasmon resonance (LSPR) biosensor based on lipid bilayers suspended over nanoscopic holes in gold films. The ultimate goal will be to incorporate membrane proteins into the suspending bilayers and use this as a platform for studies of protein function and biorecognition. LSPR will enable us to monitor mass changes correlated to the formation of the bilayers, the incorporation of membrane proteins and ligand binding in real-time by monitoring the shift of the absorption spectrum of the nanoholes. Simultaneously, electrical access to both sides of the membrane will provide a read out for membrane protein mediated ion-translocation reactions. Aiming at membrane protein microarray applications, we will immobilize different protein species by controlled fusion of protein-carrying vesicles at recognition elements on the membrane and we will demonstrate the value of the array for screening of ligands.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Automatic detection of play behaviour in young pigs as a measure of positive affective states.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The welfare of animals kept for human consumption is of high concern globally, also within the European Commission including the welfare of the domesticated pig . As animal well-being is not just the absence of negative affective states, but also, and probably predominantly, the presence of positive affective states, identifying indicators of positive affective states in farmed animals can increase our capacity to improve their health and welfare.  One such indicator is play behaviour. Play in pigs is an event occurring sporadically. Thus, using play behaviour for welfare assessment will not be possible through direct observations. Instead, it demands automation and continuous monitoring, two key elements of Precision Livestock Farming (PLF). The current project aims to investigate the relation between play behaviour in pigs and sensor data from image and sound analysis combining ethology and computer science into one field of Computational Ethology (CE). The project will focus on the CE part of the research, but the knowledge obtained could be used to develop real-time PLF algorithms for use in pig herds to observe the frequency and duration of play behaviour at pen level, beneficial to both the farmer, consultants, inspectors and future research projects within play behaviour in pigs. Training of the reseacher will include a thorough introduction to the field of CE and PLF, to the decoding and labeling of feature variables and to the use of machine learning algorithms on sensor data; all expertise fields of the hosting research group. All in all, the current project will take the first steps in developing a method for automatic recognition of play behaviour and positive affective states in pigs, as well as training the researcher for a future career within Computation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'mUltiscale IoT equipPed lonG linear infRastructure resilience built and sustAinable DevelopmEnt' (UPGRADE).

assistant: **Innovation**

Long linear infrastructure (LLIs) earthworks (e.g. road & railway slopes, pipeline bedding, flood protection structures) are more vulnerable to cascading and escalating failures, due to their topographically designed spanning length and long operational lives. With increasingly frequent severe weather conditions caused by climate change, maintaining a high level of safety performance, especially for the aged LLIs, remains a constant challenge, leading to an ever-increasing amount of investment in maintenance. Current knowledge about how these assets deteriorate over time and how deterioration affects risk and performance is patchy. The conventional engineering-oriented approach alone became insufficient to provide a solution to the complex problem like this. As we accelerate into the 21st century, the latest advances in technology, through digitalisation by integrating new revolutionary data technologies of Internet-of-Things (IoT) and artificial intelligence (AI), offer opportunities to UPGRADE our LLIs and achieve new heights in safety and performance. Highly-skilled researchers and practitioners, capable of dealing with such problems, are scarce and in high demand by both academia and industry. Therefore, formed with 11 world-leading research organisations and 6 companies across Europe, Asia and Oceania with expertise and facilities in Earth Observation, geomaterial testing, constitutive modelling, data mining, machine learning, uncertainty quantification, data-driven design and optic communication, UPGRADE aims to ensure comprehensive, robust and implementable solutions are obtained for LLIs resilience built and sustainable development. The network is carefully designed to enable research and innovation staff exchange across all aspects. UPGRADE secondees will enjoy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hybrid spin-mechanical quantum systems' (HYSPECQS).

assistant: **Innovation**

In the last years the field of optomechanics, which studies the interaction of light with mechanical oscillators, has advanced considerably. Many pioneering experiments have demonstrated the ability to achieve quantum control of meso- and macroscopic systems. However, the intrinsic Gaussian nature of optomechanical systems makes the creation of complex non-classical states of motion challenging. In order to access them a quantum non-linearity, such as an electronic spin, needs to be introduced. Achieving strong coupling between a spin and a mesoscopic mechanical oscillator would have far-reaching implications, from tests of the foundations of quantum mechanics to applications in sensing and quantum information. Despite several attempts, this regime has remained elusive so far because of limitations such as short coherence times or low spin-mechanical coupling rates. In HYSPECQS I will overcome the limitations on coupling rate and coherence time by using state-of-the-art platforms. The spin degree of freedom will be provided by nitrogen-vacancy defects in diamond, which can display hundreds of microseconds-long coherence times. The mechanical resonators, pioneered by the host group, are embedded in a thin silicon nitride membrane patterned with a phononic crystal. These resonators have been demonstrated to reach seconds-long coherence times at few tens of millikelvins. By functionalizing the resonators with nanoparticles generating high magnet field gradients, I will achieve strong spin-mechanical coupling, I will demonstrate sub-ms spin state detection with a mechanical resonator, and I will generate non-classical states of motion. The project will be carried out in the group of Prof. Albert Schliesser at the Niels Bohr Institute, Copenhagen. I will gain theoretical and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'INtelligent Video analytics to analyse complex scenes and Enhance Security of critical infrastructure and urban soft Targets' (Invest).

assistant: **Innovation**

The INVEST project brings to market readiness innovative, disruptive, intelligent video analytics (IVA) technology to create a high performance system for threat detection to protect urban soft targets and critical infrastructure. It tackles a recognised need for advanced, retrofitable systems to enhance CCTV infrastructure performance. It will rapidly identify suspects in large volumes of video data, track them in real time across multiple video systems, with reliable re-identification of targets moving between CCTV systems across a city.The expected outcome of both phases will be a complete IVA platform transforming our TRL level 6 solution into a near market ready security product (with associated services), making high throughput detection and tracking of people in crowds for the first time a practical reality. This novel system has super resolution capability, automatic detection and machine learning algorithms to filter matches offering reliable re-identification and suspect tracking.The global security sector needs a game changing critical infrastructure surveillance solution for high throughput screening from CCTV data in reasonably real-time as security teams face increased volumes of video data as CCTV installations grow (up 21% 2011-2013). In 2011 CCTV cameras worldwide captured 1.4 trillion video-hours; most of which (84% in London) went unchecked.Our innovation is applicable to a global Homeland Security market valued at €5.8bn in 2012, trebling in size by 2020. End users include national security agencies, city police forces, private sector security firms, infrastructure owners and commercial businesses.This business innovation is aligned to SeeQuestor's strategy to profitably commercialise IVA technology increasing analyst productivity by a factor of 40,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nanotechnology for Advanced Battery Energy Storage Systems' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Energy storage is an increasingly challenge as power distribution evolves to a more decentralized model with progressively higher shares of renewable energies (RE). Battery energy storage systems (BESS) are emerging as potential solutions to increase system reliability, due to their unique capability to absorb, hold and reinject electricity, as well as offer ancillary grid services. However, mature BEES technologies (e.g.; lead-acid, sodium-based and lithium ion) are still expensive, have limited lifespans and carry inherent risks. By applying nanotechnology, Greenvolt has developed Nano-Edison, a disruptive BESS that meets all the performance and criteria to couple with RE mini-grids of commercial, industrial and residential customers. Nano-Edison solution replaces the iron and nickel solid plates of the traditional Edison battery by Fe and Ni nanomaterials, retaining all original advantages (robustness, durability and safety attributes), while solves the associated downsides (manufacturing costs, low efficiency, high size and excessive weight). Compared to other alternatives, Nano-Edison offers an improved durability (+20,000 cycles), environmentally safe performance (no flammable, no acid, non-toxic metals) and the lowest production costs in the market (87 €/kWh vs. 350 €/kWh for Li-ion). Our developed and patented method for producing quality nanomaterials ensure a solid commercial proposition, that Greenvolt will monetise by licensee fees (≈300 k€/year), royalty fees (0.5% on sales) and nanoparticles supplying (89 €/kg) to large battery manufacturer partners. We expect that Nano-Edison unique selling point will enable a profitable business model that will boost the growth of Greenvolt with 5-year accumulated profits surpassing 40 M€, ROI of 8 and the creation of +5
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Innovative dual cycle tracking system for contraception and conception on a single device' (ILO).

assistant: **Concept**

Women usually track their menstrual cycle for three main reasons: As a natural contraceptive tool, to increase the chances of conceiving or for health-related reasons. However, monitoring every stage of the cycle in an accurate manner has proven challenging, due to the many variables influencing its progression (e.g. irregular periods, stress, etc.). Currently, there are two main approached to cycle tracking:  Cycle tracking devices (which represent the old-fashioned approach, fairly reliable but require self-assessment and expertise to get accuracy), and “cutting edge” app-based cycle tracking methods (which are user-friendly, but rely in subjective facts related to the period - e.g. length or amount of bleeding-, traditional measurements -e.g. core body temperature- and algorithms, and lack accuracy. Hence, none of these approaches fulfils the “golden” criteria of being reliable, precise, simple and non-invasive. At Carbomed, we strive to overcome the limitations of both approaches thanks to our innovative ILO system, the seamlessly combination of a handheld device and an app, that reliably predicts the time of ovulation by relying on a scientifically-based method: Measuring the CO2 levels from exhaled air. ILO conveys the best features from both approaches, being accurate, simple and non-invasive while providing a user-friendly experience thanks to our bespoke app. ILO can be used as a dual cycle tracking device predicting the most fertile window, as a natural contraceptive method, but also as a tracking device for those who want to get pregnant. For Carbomed, ILO represents a large business opportunity, aimed initially at the child wish market and subsequently (and most importantly) at the contraception market valued at €17.6 billion back in 2016. In this way, we ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Epigenome Maintenance on Sister Chromatids', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

DNA replication not only involves the copying of the genome to propagate cell identity to daughter cells but also of the epigenome, where histones and their post-translational modifications (PTM) are accurately maintained in replicated chromatin. This is achieved by a strikingly coordinated process that ensures accurate, symmetric recycling of H3-H4 tetramers to both daughter strands, thus forming the basis of epigenetic memory. Recently, I identified H2A-H2B PTMs to be also symmetrically recycled in a H3-H4-independent manner. The underlying mechanism and their role in epigenetic memory remain unclear. Moreover, whether the asymmetric nature of DNA replication (leading vs. lagging strand) leads to asymmetric chromatin landscapes on daughter strands per se remains unexplored due to the current lack of technologies.I hypothesize that propagation of cell identity to daughter cells requires crosstalk of conserved “memory modules” (on H3-H4 and H2A-H2B) to equilibrate the asymmetric mode of DNA replication. We will use both stem cell culture and fission yeast to define evolutionarily conserved concepts of chromatin restoration after replication. To this end, we will extend state-of-the-art sequencing, proteomics, genome editing, as well as established and novel nucleotide labelling approaches. First, we will address the molecular mechanism of H2A-H2B PTMs recycling during replication. Second, we will test the role of active chromatin PTMs in maintaining chromatin states, 3D chromatin organization, and gene expression after replication. Third, we will develop a novel strand-specific labelling technology to determine the composition and restoration principles of leading and lagging strand-replicated chromatin.This proposal will directly dissect the function and relevance of e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Smart Process Optimised Tool (SPOT), an Industry 4.0 world first approach for reliable and repeatable crimping and cutting hand tool technology'.

assistant: **Objectives**

There is an urgent market demand to eliminate the risk of human error and increase crimping accuracy, from the current 20-25% fail rate. This is particularly prevalent in the automotive and aviation sectors, for safety-relevant components such as airbags, brake systems and on-board electrical systems. In response, we have developed SPOT, an HMI, Industry 4.0 solution that improves process reliability to a 0% fail rate.SPOT contains a new state-of-the-art sensor technology, a patented force distribution system as well as an advanced intelligent central unit. These features enable the tool to perform an optimal force measurement and record the accuracy and quality of the crimp.  Additionally, as we have miniaturised, a benefit is realised enabling crimping of extremely small wire diameters as well as high forces despite the manual operation.As a new generation of tool and with our IP position protected, we intend for SPOT to become the industry standard and pave the path for us to maintain our market leadership for decades, therefore, it is key for us to plan this market entry strategy carefully to ensure success is maximised. This feasibility study will allow us to: refine our market knowledge; plan our scale-up for manufacturing; finalise Phase 2 project partners and produce a fully elaborated business plan.As an Industry 4.0 evolution of hand tools, it is necessary for us at WEZAG to build up our internal knowledge for electrical engineering and electronics. This will be achieved via recruitment and training. However, with a legacy as an innovative company, we possess the know-how required to successfully develop, manufacture and market such world novelties and innovations.Having already proven TRL6, at Phase 2 we shall: finalise tool development; create a varying crim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Assessment and reduction of heavy metal input into agro-ecosystems'.

assistant: **Objectives**

The overall objective of this Concerted Action is to establish a European research network on the heavy metal problem in agriculture in order to foster the efficiency of the research activities. This includes ecological, economic, legal and social aspects. All available data and information on heavy metals in respect to agriculture will be collected, input / output balances will be calculated and areas of main concern defined. Following that, the participants will work out ways of reducing the heavy metal input into agro ecosystems and recommendations for changes of the relevant legal regulations will be made. Finally the results will be presented to the public at an international conference.