RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Efficient algorithms for sustainable machine learning' to be submitted under Horizon 2020.

assistant: **Abstract**

This project will  develop and integrate the latest optimization and statistical advances into a new generation of  resource-efficient algorithms for large-scale machine learning. State-of-the-art machine learning methods provide impressive results, opening new perspectives for science, technology, and society. However,  they  rely on massive computational resources to process huge manually annotated data-sets. The corresponding costs in terms of energy consumption and human efforts are not sustainable.This project builds on the idea that   improving efficiency is a key to scale the ambitions and applicability of machine learning. Achieving efficiency requires overcoming the traditional boundaries between statistics and computations, to   develop new theory and algorithms. Within a multidisciplinary approach, we will establish  a new regularization theory of efficient machine learning.We will  develop models that incorporate budgeted computations, and  numerical solutions with resources tailored to the statistically accuracy allowed by the data. Theoretical advances will provide the foundations for novel and sound algorithmic solutions.  Close collaborations in diverse applied fields will  ensure  that  our research results and solutions will be apt and immediately applicable to real world scenarios. The new algorithms  developed in the project will contribute to boost the possibilities of Artificial Intelligence, modeling and decision making in a world of data with ever-increasing size and complexity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Glycolipid cholesterol interactions: towards an understanding of mechanisms of lipid raft formation', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Lipid rafts have been proposed to play a major role in protein functionality in cellular membranes, yet the underlying physical mechanisms are not properly understood. Here, we propose a project focusing on atomistic level understanding of a number of fundamentally important issues related to raft formation. We employ atomistic molecular dynamics simulations to a variety of bi-layer systems that have been suggested to play a key role in lipid rafts. Specifically, we aim to resolve structural as well as dynamical differences between glycolipid-cholesterol, phosphatidylcholine-cholesterol and sphingomyelin-cholesterol membrane systems.Hydrogen bond networks between lipid head-groups, hydration, water -mediated interactions of head-groups, and van der Waals intera ctions between hydrocarbon chains are of special interest. Correlation between these interactions and the bilayer structure and dynamics will be elucidated. Overall, results obtained in this project allow us to better understand the atomic level mechanisms of raft formation and, consequently, protein function.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Selective Pathways for Carbon-Nitrogen Bond Cleavage' (SCAN) targeting Horizon 2020.

assistant: **Abstract**

Amines are ubiquitous across natural products, pharmaceuticals, polymers and biomolecules. The number of commercially available amines, from simple to complex, makes them one of the most accessible native functional groups. Therefore, they represent an attractive feedstock for the preparation of functionalized molecules through C-N bond activation. Nature long ago developed protocols to promote oxidative deamination reactions. Inspired by this approach, SCAN (Selective Pathways for CArbon-Nitrogen Bond Cleavage) is designed to open new directions in the field of C-N bond cleavage by unlocking the oxidative deamination pathway. To achieve this goal, the following specific objectives are proposed: 1) Design of redox-active amines capable of undergoing oxidative C-N cleavage. 2) Development of novel oxidative deaminations using photoredox and metallaphotoredox catalysis.3) Site-selective modifications of peptides through photocatalyzed oxidative deaminations. The successful implementation will allow the use of one of the most readily available functional groups in a myriad of novel catalytic transformations, including for the first time asymmetric catalysis. The prevalence of alkyl amines in pharmaceuticals makes SCAN an ideal tool for late stage functionalization and molecular editing of complex molecules. Moreover, this reactivity could be used to achieve site-selective modifications of NH2 groups in peptides via C-N bond cleavage, which would have a profound impact in the fields of chemistry and chemical biology. Together, the conceptual novelty, the ability to pursue multiple complementary approaches at once, and the various potential applications will ensure high impact of this project in both the academic and industrial communities.


**Keywords:** Amines, C-N activa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Microbiome-Microglia interaction in Alzheimer's disease' (MiMi-AD).

assistant: **Innovation**

Alzheimer’s disease (AD) affects over 55 million people worldwide, with no effective treatments currently available. Understanding early-stage mechanisms of the disease is critical to developing new therapeutic approaches. Microglial cells, key regulators of amyloid-beta (Aβ) clearance and neuroinflammation, are implicated in the progression of AD. Emerging evidence suggests that the gut microbiota, through its influence on microglial function, may play a pivotal role in AD pathogenesis. However, the precise regulatory mechanisms of the gut-microbiota-brain axis in AD remain unexplored.The MiMi-AD project, aims to elucidate the role of gut microbiota in modulating microglial activity across AD progression stages, using the Tg2576 mouse model of AD. Specifically, the project will investigate whether exercise-induced alterations in gut microbiota can prime microglial cells to promote Aβ clearance, delay cognitive decline, and reduce neuroinflammation. The research will employ cutting-edge transcriptomics, metabolomics, and microbiota analysis to explore these dynamic interactions, along with in vivo and in vitro studies to identify targetable microbial metabolites.The outcomes of this research could identify novel gut-brain axis pathways, providing a foundation for therapeutic strategies aimed at delaying the onset of AD. Through interdisciplinary collaboration, this project aligns with European and global priorities in promoting healthy aging, offering potential benefits for individuals at risk of developing AD.


**Keywords:** Microbiota-gut-brain axis, Microglia, Alzherimer's disease, Neuroinflammation, Hippocampus, Exercise , Multi-omics, Microbial metabolites, Metagenomics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Women Tech EU x CTD AS' under Horizon Europe.

assistant: **Concept**

Primary objectives are market mapping and scaling growth related to our business plan. It is highly relevant to implement these in our strategic planning and development from an early stage to assess our market opportunity at a fast pace. Secondary objectives are preparing our business for expansion through insight into public procurement and employment.Up until today we have gained information on the market situation for VR training in Norway, and characteristics that are important to take into consideration in our country. However, we are focusing on developing VR-training on international standardized procedures, confirming a great potential for our solution outside of the country. In order to succeed, we need to dedicate resources to execute an analysis of the international market. In particular, we need to conduct a competitor landscape analysis in the field. This includes addressing suppliers of medical training in VR and suppliers of e-learning for procedural training. Additionally, we need to address which markets will be our primary objectives for future expansion. These will be addressed by conducting a target market analysis and industry overview. We thereafter need to get insight and knowledge on the purchase process for our primary objectives, besides building the foundation for our employment.Women TechEU can help our business growth strategy both through mentorship and financing. We would benefit from having a mentor with experience from working with business in a fast-paced growth environment. Furthermore, we would benefit if the mentor had worked with MedTech and/or internationalization. It would be valuable for us to have a mentor that could play an active role in helping us improve our starting point related to facing the demanding and time-consuming
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Regulation and Evolution of C4 photosynthesis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Life is dependent on sugars made during photosynthesis. When plants colonized land ~450 million years ago they used a photosynthetic system known as the C3 pathway that still operates in the majority of species today. However, from ~30 million years ago over sixty plant lineages evolved a version of photosynthesis known as the C4 pathway that increases CO2 fixation efficiency by about 50%. C4 species such as maize and sorghum are now the most productive on the planet and achieve this by compartmentalizing gene expression between cell-types.As with other complex biological systems made up of multiple distinct cell-types, it has not been possible to understand how photosynthesis genes are regulated in specific cell-types of C4 leaves. In contrast to strategies being used by other groups, I propose to discover how specific cell-types of ancestral C3 leaves regulate gene expression, and then to use this information to determine how C4 photosynthesis operates. To achieve this, state-of-the-art approaches used on whole tissues will be adapted to study individual cell-types.Revolution will test the hypothesis that cell-specific gene expression in C4 leaves is mediated by pre-existing regulatory networks found in C3 species. Intracellular mechanisms regulating photosynthesis genes in ancestral C3 but also derived C4 leaves will be identified. In C3 leaves I wish to understand how some cell-types express photosynthesis genes whilst others remain photosynthetically repressed. In C4 leaves I wish to discover the extent to which cell-specific expression is based upon pre-existing regulatory networks in the C3 leaf.Revolution will therefore generate information of broad relevance to understanding gene expression in eukaryotes, and provide insight into mechanisms underpinning one of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A virtual platform in which participants in a meeting are able to communicate and transmit information in real time, independently of specific place, supplier and choice of information bearer (e-meeting platform)' to be submitted under Sixth Framework.

assistant: **Abstract**

In existing digital services and systems for meetings and conferences the users are not flexible or mobile. They are tied to one suppliers service and in general restricted to one type of information bearer. Most solutions are so technically advanced, that learning and handling are viewed as obstacles. These solutions are usually costly, therefore not widely used.The SMEs need to, unrestricted by distances and national borders, increase their competitiveness by cooperation. There is also a need to increase efficient co-operation in public institutions and between these and society in general, thereby improving efficiency and reducing labour costs in the public sector. The proposedsolution is meant to help meet these needs.The objective of the project is to create a platform, an easy to use, quick to access and low cost tool, in which participants in a meeting are able to communicate and transmit information in real time The unique aspect here is that the participants can do this independently of specific place, supplier and choice of information bearer. The method of the project is to utilise existing, by users accepted, technologies for communication and then create means to connect these to and through the platform. The project consists of two fundamental parts. One part entails adding softer functions, interfaces and tools to this real time platform. The other part is the technical development of the underlying platform.The proposed solution enables the individual to, attend or run virtual online meetings while exchanging documents, enter discussions and make comments, keep abreast with developments in projects. It could probably contribute to a better environment by reducing the need for business travel. The projects inter-disciplinary approach with a parallel devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dynamical control of Spintronic devices through solid-state gating' (SpinDy) targeting Horizon Europe.

assistant: **Abstract**

The increasing dependence of everyday life on digital technologies raises challenges for materials science. Data is becoming one of the most precious assets of modern society, and its storage and processing require more and more electrical power. In order to keep this energy consumption under control, new technologies are emerging that shift the paradigms of computation. Among these, the field of spintronics holds potential to meeting the current requirements of dense, nonvolatile data storage and logic technology in which information can be written, manipulated and read as efficiently and as fast as possible. The main goal of the SpinDy project is to develop innovative and sustainable spintronic devices. The basic concept behind my proposed approach is to use solid-state gating to act on the device structure during operation and thus tune its functionality dynamically. This will allow to perform low-power reading and writing operations without compromising the stability of the device for long-term information retention. I will implement this working in two parallel directions. The first is by achieving voltage control of orbital currents in light transition metals, which in turn allows to tune the torque efficiency at the interface between the metal and a magnetic material. The second is by manipulating the magnetic properties of a rare-earth-free ferrimagnetic layer through electrical gating. Finally, I will combine aspects of both approaches to develop proof-of-principle dynamical spintronic devices that can act as memory or for logic operations with enhanced performances in terms of energy efficiency and stability thanks to their tunable nature. The main outcomes of the SpinDy project display aspects of great interest from both applied and fundamental points of view
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Fast and Accurate Solubility for Sustainability' (FASS) under Horizon Europe.

assistant: **Objectives**

Solubility measurement is a standard test that is required for every chemical that is produced or tested. However, measuring solubility is a time/labour-intensive process that requires substantial quantities of chemicals. State-of-the-Art solubility measurements are either fast but inaccurate or slow but accurate and require excess of chemicals. FASS is based on high-efficiency second harmonic scattering that combines the analytical advantages of current solubility measurements, fast and accurate, while achieving cutting edge performance in sensitivity and reliability. FASS saves 90% of cost, 90% of measurement time, 99% of chemicals and 97% of electricity and 80% of compounds compared to the gold standard. As an optical light scattering technique, FASS is non-destructive, and combined with analytical advantages and sustainable use of chemicals and compounds, provides a disruptive innovation in solubility measurement. The consortium is composed of a dedicated startup to bring the instrument to market, a research and technology organization to support technology maturation, a European Research Consortium to enable customer development and instrument demonstration and a center for pharmaceutical research to explore value-added applications of FASS in drug discovery and development. The goals of the project are:  1) to develop a demonstrator with optimized and robust performance suited for instrument demonstration and application exploration. 2) to validate the technology with early adopters in early stage drug discovery and development and chemical synthesis companies. 3) to develop a feasible business model and go-to-market strategy to be implemented by the startup. FASS brings a sustainable solution to the pharmaceutical and chemical industries, reduce chemical and elec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Energy Trusted Advisor for Buildings' (ETA4B) targeting Horizon 2020.

assistant: **Abstract**

ETA4B (Energy Trusted Advisor for Buildings) project promotes the development of an embedded energy optimization system collaborating with existing devices, providing citizens with innovative applications and services in the field of energy efficiency of buildings, making home more smart.The solution includes a multi-protocol electronic unit to be easily installed in houses and small buildings, providing an open-framework web-based platform with energy-related data flow for supporting the decision making process for end users. Benefits for users are in terms of energy saving (cheaper bills), CO2 emissions reduction and, for the ones being “prosumers” (energy users that also produce energy in their buildings), low production costs and higher profits. For Tera Srl, the challenge is to enter in the energy efficiency market thus enhancing company’s profitability. The main customers will be “prosumers”, addressed through an innovative commercial approach, based on web applications managed by skilled companies selling a modular and scalable service, rather than a device that will be introduced in the energy efficiency market for small buildings.  Strong innovation also lies in the combination of automatic SW updating capability at front-end (no needs for maintenance and ease of use) and powerful reasoning engines at back-end. These SW engines are based on energy-model calculations and big-data like algorithms, running both on private and public data-base (open-data), delivering “customized” performance indexes to the users.To demonstrate the feasibility of ETA4B, Phase 1 activities will focus on specific components such as target market, partner search, value proposition, compliance to cutting-edge standards and development platforms, financial sustainability and business mod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Joint assimilation of satellite aerosol, cloud, and precipitation observations in numerical models to support climate and hydrologic applications' (JOINT-ASSIMILATION) targeting Seventh Framework.

assistant: **Abstract**

Clouds and their interaction with radiation represent one of the largest uncertainty in climate and weather prediction. This is because clouds result from processes and depend on variables such as aerosols that have not comprehensively observed until recently. The advent of the satellite technology made possible the continuous monitoring of clouds and related variables from space.  Our primary research objective is the use of existing satellite aerosol, cloud and precipitation observations to gain insight into cloud processes and their impact on climate and weather.  Specifically we intend to assimilate satellite observations into a state of the art cloud-resolving atmospheric model.  This will facilitate a better analysis of  the interaction between clouds and large scale processes and allow for the development of better cloud microphysical schemes.  Based on the analysis, the impact of aerosol of climate and weather will be rigorously assessed.  The project will also facilitate the re-integration of Dr. Mircea Grecu into an European Research Institution. The Hellenic Center for Marine Research is commited to support this re-integration by offering Dr. Grecu a four-year long appointment.