RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Relating mitotic control to the mechanics of cell division'.

assistant: **Innovation**

We will utilise the genetic, developmental, and cytological advantages of genetics, cell and developmental biology, with biochemistry. It thereby Drosophila to study the centrosome cycle and cytokinesis, both of which closely resemble analogous processes in mammalian cells. Mitotic entry provides an ideal training ground for a multidisciplinary approach to a fundamental biological problem. The collaborating laboratories each have requires the P34 kinase activated by cdc25. We will study the roles of two genes that we have identified that regulate a Drosophila cdc25 homologue, skills that span these experimental disciplines, although having some degree of specialisation so that collectively they can provide all of the one of which appears to affect centrosome behaviour. We will characterise mutations in the two Drosophila genes for gama-tubulin and identify genes necessary expertise and training to the proposed postdoctoral workers encoding proteins that interact with gama-tubulin within the centrosome.Centrosome separation and spindle formation will be studied with reference to the phosphorylation- cycles of kinesin-like proteins and other centrosomal components by the polo kinase and protein phosphatase 2A. We will characterise several genes essential for cytokinesis, and study their interactions with reference to the localisation and phosphorylation of the gene products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'New increased temperature capability thermal barrier coatings' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The aim of this project is to develop a thermal barrier coating (TBC) system for hot section components of gas turbines (GT) with a 50°C minimum increase in operating temperature over the current state of the art coating (7-8% Y203 partially stabilised ZrO2, YSZ) thereby maintaining the good material properties of YSZ. This will allow higher turbine entry temperatures, and, hence, more efficient GT engines with reduced fuel consumption and fewer harmful emissions. The possibility of compositional and morphological changes to the existing TBC system will be investigated, as well as, new coating compositions based on other than ZrO2. Standard production techniques will be employed for coating deposition. Initially, a total of twenty different systems will be screened w.r.t. their most critical properties (i.e. phase stability and sintering resistance). After a thorough assessment of screening test results in reference to project objectives six systems will be selected for processing in industrial equipment and further evaluation. The performance of the TBCs will be experimentally quantified and described by theoretical means and benchmarked with reference systems. All evaluations will include virgin and aged samples. The best coating systems will be tested and ranked in service.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Neutrino Oscillations and Phenomenology of Massive Neutrinos' (NEUTRINOOSC), addressing dissemination and exploitation.

assistant: **Impact**

Neutrino physics is one of the most active and exciting fields in today's particle physics. Thanks to recent outstanding experimental results we have now evidence that neutrinos do oscillate, which implies that they have mass. As a consequence these particles provide the first solid evidence for physics beyond the Standard Model, our current theory for the fundamental components of matter and their interactions.This project deals with various aspects of neutrino physics from a theoretical point of view. Open questions related to neutrinos will be addressed, like the value of the third (so-far unknown) mixing angle, leptonic CP violation, the type of the neutrino mass spectrum, or the absolute neutrino mass scale. The project includes global analyses of experimental data, the phenomenological investigation of sub-leading effects in neutrino oscillations, and the consideration of possible non-standard neutrino properties.Furthermore, topics like neutrino-less double beta decay, and cosmological implications of massive neutrinos will be considered. Analytical methods, as well as detailed numerical simulations will be used to investigate the fundamental properties of neutrinos. Such investigations are an important step to identify optimal future experimental strategies in neutrino physics, and hence the project will contribute to further establish Europe and apos;s role in this field. Concerning more theoretical aspects, the fact that neutrino masses are many orders of magnitude smaller than all other masses of known fermions indicates the existence of a new fundamental scale in physics. Therefore, the investigations proposed here may lead to new insights into a more complete theory beyond the Standard Model.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The ethics of human stem cell research and therapy in europe' (EUROSTEM), addressing dissemination and exploitation.

assistant: **Impact**

EUROSTEM will provide an ethical framework for stem cell research; will monitor the ongoing natural experiment" in the United Kingdom and other countries with such research, and the regulatory and legal issues involved. The need to analyse and understand the public response to this research is equally important and this need is fully recognised and responded to. Human Stem Cell Research is at the cutting edge of health and biosciences research, the innovative science involved creates ethical dilemmas that have as yet been insufficiently studied and poses challenges for our understanding of fundamental human values. The use of human stem cells raises many issues, for example: the moral status of the embryo, the consents required to use Embryonic Stem cells and other genetic material, genetic privacy and ownership of genetic information. Some of these issues concern the symbolic significance of what is done as opposed to utilitarian accounts of the meaning of the procedures. The possibilities for copying, and using a particular human genome via cloning technology have created unprecedented issues concerning human dignity and rights which will be fully explored and analysed."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Genetic contributions to inequality of opportunity' to be submitted under Horizon 2020.

assistant: **Abstract**

Equal access to college education is a hallmark of egalitarian societies. This is not the case in both the United Kingdom and United States: children from low income households with high standardized test or exam scores are less likely to attend college than children with equal test scores from high income households. However, eliminating family income as a source of unequal college access may still leave inequality of opportunity to attend college and accordingly to accumulate wealth based on another family factor: genetics. Educational attainment is partially heritable, and recent studies have identified specific genetic variants. Despite both a longstanding debate and recent interest in the topic, there is no methodological framework for studying genetic contributions to inequality of opportunity. The first aim of the project is to develop this methodological framework [OB1] by exploiting bioinformatics techniques to measure genetic endowments, econometric techniques to measure returns to genes and inequality of opportunity, and by using sociological theory to interpret the findings and address any normative implications [WP1]. The considered outcomes are income, wealth, and overall health and well-being, as higher educated individuals typically enjoy longer, healthier, and happier lives in addition to higher incomes and accumulated wealth. The second aim [OB2] of the project is to apply this methodological framework to visualize how socioeconomic inequality of opportunity varies by sex and geographic location [WP2]. The third aim of the project [OB3] is explore how the population-level applications developed in [WP1] and [WP2] carry over to the individual level [WP3]. The project crosses disciplinary boundaries by incorporating knowledge and tools from genomics, eco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Computational Modeling and Design of Lithium-Ion Batteries' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Lithium-ion batteries (LIBs) are among the most promising solutions for energy storage. Compared with other resources such as bio-fuel, solar cells, fuel cells or lead acid batteries, rechargeable batteries are more portable and allow for quick energy storage and release. The higher power and energy density make batteries suitable as the energy resource for most portable elect. devices including future vehicles. Among the rechargeable batteries, LIBs have the most potential because of their quick charging rate and high power and energy density. However, ageing of LIBs and the related capacity and power fade is a major concern. For the improvement and future development of batteries, computational modeling and design is an important complementary part to experimental testing which is expensive, time-consuming and sometimes unfeasible.In this project, the PI proposes to develop, implement, verify and validate a computational multifield and multiscale framework to support the design and optimization of new batteries. The computational framework will support the design and optimization of new anode, separator and cathode materials as well as their structure inside the battery. The measurable outcome of this research will be an open-source software package that can be used to support the design and optimization of LIBs.Within the computational framework, different (mechanical-thermal-electro-chemical) fields will be linked over multiple scales: from fundamental physics to the design of new battery materials. We will quantify uncertainties in order to provide upper and lower bounds of our predictions and use graph-theory, error-estimation and adaptivity to choose the appropriate model and discretization. The computational framework will be verified and validated by comparison
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Combinatorial Biosynthesis of Industrial Glycopeptides: Technology, Optimization and Production' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The focus of this proposal is on glycopeptides, a class of antibiotics where room for improvement is anticipated and the second-generation glycopeptide dalbavancin is under development by one SME of this team. The objectives of this proposal are directed at generating more effective glycopeptides by combinatorial biosynthesis and at speeding up the development of promising glycopeptides through improvement of the fermentation process. The project will start with the generation of novel peptide backbones, either chemically or by exchanging gene fragments determining amino acid specificity. Genes involved in subsequent tailoring reactions, such as the coupling reactions, glycosyl transfer, halogenation, and the supply of activated sugars or amino acid precursors will be collected from glycopeptide producers or identified by genetic screening. Knowledge of the enzymatic reactions will enable gene combinations to generate novel glycopeptides with altered backbones, novel glycosylation patterns, and other modifications. These compounds will be tested for their effectiveness as antibiotics. To bring forward drug candidates, we will combine post-genomics techniques (proteome/transcriptome) with modern molecular biotechnology to optimise the production process. This will be achieved by flux analyses and 2D-maps for discovering primary metabolism proteins up-regulated during glycopeptide production. Combined with a study of other limiting steps, such as precursor uptake and productexcretion, and with transcriptional regulation of glycopeptide genes, bottlenecks in production will be identified and eliminated, allowing the construction of an improved production strain, usable also for the novel glycopeptides generated by the project. By combining combinatorial biosynthesis integr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Sphingolipid homeostasis: from basic biology to applications' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

SPHINGONET was inspired by a common vision of its partners on the training of researchers in the field of sphingolipid homeostasis and body-wide sphingolipid signaling networks using innovative technological approaches. Dysregulation of sphingolipid balances contributes to a broad range of pathological processes, spanning neurodegeneration, asthma, autoimmune disease, insuline resistance, obesity and cancer progression. Key to defining proper sites for therapeutic intervention is a comprehensive understanding of the mechanisms of sphingolipid homeostasis and how sphingolipid-mediated signaling pathways are interconnected. In spite of its many clinical implications, progress in this field is curbed by a lack of appropriate tools to monitor, quantify and manipulate sphingolipid pools in live cells. SPHINGONET’S training program is designed to close these gaps in knowledge and technology by transferring the complementary expertise of its partners to a future generation of scientists who will take a leading role in decoding the full regulatory potential of the sphingolipid signaling network and maximize its therapeutic use. By merging seven academic partners working at the forefront of sphingolipid, chemical and systems biology with three (pro)drug discovery-oriented SMEs, SPHINGONET will create a challenging interdisciplinary and clinically-relevant research environment with ample opportunities for structuring industrial projects, commercial exploitation of results, entrepreneurship and complementary education adapted to the personal needs. Thus, SPHINGONET will provide its trainees with a rounded education that, besides enhancing their career perspectives, will enable them to choose a career path in Europe’s academia or industry, and be successful at it while retaining ti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The dynamics of genetic rescue from natural migrations in wolves' in the context of a Horizon Europe call.

assistant: **Objectives**

Dramatic biodiversity declines are driving Earth into a Sixth Mass Extinction. Drastic conservation plans such as genetic rescue have been proposed to mitigate the loss of genetic diversity, by introducing variation through admixture with closely related populations. However, the influx of new variation can also lead to an increase in genetic load, which can further compromise the survival of species. Since current studies of genetic rescue are based on few regions of the genome and lack a population genetics model, assessing the impact of these initiatives on the levels of genetic diversity and genetic load remains elusive. I propose to tackle this by studying the natural populations of European gray wolves in a temporal and spatial model, as their recent demographic history (strong bottleneck followed by a recovery in last decades) renders them an ideal case for exploring the dynamics of genetic rescue. In particular, I propose to leverage on an unprecedented dataset including >1,000 wolves genomes sampled across Eurasia at multiple time points (before and after population decline and the subsequent recovery) to generate the most comprehensive catalog of genomic diversity in European wolves to date. Taking advantage of recent developments in population genomics, computational biology, palaeogenomic sequencing and evolutionary modeling, I will reconstruct their recent demographic history, migrations patterns and adaptive potential, and determine the demographic parameters that predict a successful genetic rescue. This predictive modeling tool will be capable of guiding conservation management in wolves and applicable to other endangered populations. The combination of my host’s extensive experience in canid evolution, statistical methods and modeling, together with my
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Mechanically tuned Lung-on-a-Chip device to model pathology and drug screening for lung disease'.

assistant: **Innovation**

The aim of this project is to design a total lung-on-a-chip microfluidic device with a mechanically relevant air-liquid interface to create a cellular environment with more closely matched physiological and functional complexity than conventional lung models. Specifically, we will (i) integrate bronchiole and alveolar sac functional regions of the lung into one chip, and (ii) incorporate a relevant and tunable biomechanical profile into the gas-permeable membrane (mimic of air-liquid interface). This device will address the large and currently unmet need to model organ-level complexity of cells in vitro, in particular with regards to spatial and mechanical cues important for cell function, and provide a superior platform to model lung physiology, function and lung disease treatments. The project will be based on the state-of-the-art technical expertise of Elvesys in microfluidic chip design, fabrication and exquisite control of microfluidic parameters for advanced cell culture, and will fully integrate the Experienced Researcher’s (ER) strong expertise with elastic proteins, liquid interfaces, biomaterial design and mechanical testing to tune membrane stiffness and bioactivity by blending synthetic polymers and natural elastic proteins. Testing, validation and benchmarking of the product will be by perfusion using a set of candidate drugs chosen in consultation with clinician collaborators. This technology will offer clinicians a choice of lung model that is mechanically relevant to a patient’s lung profile (e.g. equivalent to physiological, stiffer or less stiff) for pre-screening of drug efficacy, dosing and toxicity. Through this opportunity the ER will be immersed in a richly entrepreneurial environment at Elvesys and exposed to marketing concepts, IP and patenting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Engineering homeostasis into living materials'.

assistant: **Innovation**

Engineered Living Materials (ELMs) are dynamically emerging at the intersection of synthetic biology and materials sciences and are providing solutions in a rapidly growing number of application fields. Current areas of application comprise, for example, biomedicine, textiles, sensors, soft robotics, electronics, or construction materials. From a conceptual point of view, ELMs provide the opportunity of endowing materials with properties and functions long sought for in materials sciences, such as adaptivity and interactivity, evolvability, hierarchical design, self-reproduction, energy harvesting from the environment, synthesis from renewable resources, as well as biodegradability. Despite intensive research, however, a key defining property of life is largely missing in ELMs, that is homeostasis. Homeostasis is the ability of a system to maintain an inner steady state despite external fluctuations that impact this state. For example, mammals maintain a constant body temperature despite varying external temperatures.  In STEADY, we will develop and test the concept of engineering homeostasis into living materials. To this aim, we will develop three genetically encoded modules, (i) a sensor to sense the actual state of a specific mechanical property of the material, (ii) a controller to process the sensor signal, and (iii) an actuator, that, based on the controllers output, steers the material towards the setpoint. The design of the homeostatic system will be highly modular, so that the sensor and actuator can be adapted in order to maintain homeostasis for other properties or functions of the material. The tools developed here are not restricted to ELMs but may also be used to confer homeostasis to polymer-based soft materials with regard to maintaining a desired featu