RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Uncovering antiviral mechanisms in the insect gut during oral virus infection'.

assistant: **Concept**

Insect-mediated transmission of viruses is an increasing threat to public health and agricultural productivity in Europe and abroad. New strategies to disrupt transmission of viruses by insects are essential and will be facilitated by knowledge of infection processes and antiviral mechanisms. Most transmission cycles involve oral acquisition of viruses by insects, but knowledge of oral virus infections is limited. Here I propose the DmGAR project (Drosophila melanogaster gut antiviral responses) to provide the first detailed picture of oral virus infection processes in the insect gut. I aim to harness the experimental tractability of D. melanogaster to characterize the dynamics of and genetic responses to oral virus infection and to investigate the interface of viral infection with intestinal physiology.I hypothesize that stem cell-driven gut epithelium renewal is coordinated with immune mechanisms and is crucial for clearance of oral virus infections. To investigate this hypothesis and accomplish the objectives of DmGAR, I will bring my expertise in host-virus interactions to the Saleh laboratory to study oral infections with naturally infecting viruses of D. melanogaster. I will spatially and temporally define the kinetics and outcomes of infection, determine whether the viruses spread beyond the gut, and if escape from the gut influences infection outcome. Informed by these data, I will evaluate if virus infection impacts rates of epithelial cell death and/or proliferation in the gut and if blockage of epithelial cell turnover influences virus titer, infection outcome, or infection kinetics. I will complement these studies by profiling cell-type-specific gene expression and assaying activation of cell signaling pathways to develop a mechanistic model of the response
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cortical feedback in figure background segregation of odors.' (COFBMIX).

assistant: **Innovation**

A key question in neuroscience is how information is processed by sensory systems to guide behavior. Most of our knowledge about sensory processing is based on presentation of simple isolated stimuli and recording corresponding neural activity in relevant brain areas. Yet sensory stimuli in real life are never isolated and typically not simple. How the brain processes complex stimuli, simultaneously arising from multiple objects is unknown. Our daily experience (as well as well-controlled experiments) shows that only parts of a complex sensory scene can be perceived - we cannot listen to more than one speaker in a party. Importantly, one can easily choose what is important and should be processed and what can be ignored as background. These observations lead to the prevalent hypothesis that feedback projections from ‘higher’ brain areas to more peripheral sensory areas are involved in processing of complex stimuli. However experimental analysis of signals conveyed by feedback projections in behaving animals is scarce. The nature of these signals and how they relate to behavior is unknown.Here I propose a cutting edge approach to directly record feedback signals in the olfactory system of behaving mice. We will use chronically implanted electrodes to record the modulation of olfactory bulb (OB) principal neurons by task related context. Additionally, we will record from piriform cortical (PC) neurons that project back to the OB. These will be tagged with channelrhodopsin-2 and identified by light sensitivity. Finally, we will express the spectrally distinct Ca++ indicators GCaMP6 and RCaMP2 in PC neurons and in olfactory sensory neurons, respectively, and use 2-photon microscopy to analyze the spatio-temporal relationship between feedforward and feedback inputs in the OB
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Vocal athletes:  Behavioural and brain bases for phonetic aptitude in monolingual and bilingual learners of a foreign language' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Many learners of a foreign language struggle to correctly pronounce newly-learned speech sounds so that they can be understood by native listeners. Yet many others achieve this with apparent ease. What is responsible for these large individual differences in phonetic aptitude? Are better speakers also better listeners? The aim of this proposal is to determine whether there is a link between skills in production and skills in perception in learners of a foreign language. A special focus of the research will be to compare bilingual with monolingual learners, because bilinguals have had more experience with linguistic variation than monolinguals, and therefore might have greater phonetic aptitude. Bridging traditional linguistic and newer cognitive neuroscience approaches, the proposed study will determine the behavioural and brain bases for phonetic production and perception abilities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Detecting, understanding and exploiting intracellular redox signaling relays' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Redox signaling is a process by which endogenous oxidants, derived from metabolism, reversibly modify particular thiols on particular proteins to change their functional behavior in an adaptive manner. However, the molecular mechanisms of redox signaling remain largely unknown. In particular, specificity and efficiency of redox signaling remain unexplained. The now emerging solution to this conundrum is that redox signaling is mediated and channeled by protein-to-protein redox relay chains that dynamically assemble in the cytosolic, nuclear and mitochondrial compartments. We and others have found that H2O2 signals are relayed through thiol peroxidases to neighboring proteins within supramolecular assemblies. Evidence now suggests that so far we have just glimpsed the ‘tip of the iceberg’, namely that redox relay chains are ubiquitous and also operate for reactive nitrogen and sulfur species. This project aims to systematically uncover, dissect, monitor and manipulate the redox relay chains that give specificity and efficiency to redox signaling. The basic strategy is to tag all protein-coding genes with genetically encoded reporters which –within the context of the living cell– sense the transmission of thiol oxidizing equivalents within their sphere of immediate proximity (≈10 nm). A combination of genetic screening, redox proteomics and transcription profiling will then allow to identify the composition of redox relays, their endogenous target proteins und their functional impact on gene regulation. The knowledge about the composition of redox relays will lead to precision tools for the observation and manipulation of defined redox signaling pathways in vivo. The project is expected to yield fundamental insights into the specific molecular links by which reactive oxyg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sediments and Subduction Interface Mechanics: from micro-scale creep to global plate tectonics' (S-SIM) under Horizon 2020.

assistant: **Objectives**

This project seeks to test the hypothesis that sediment subduction strongly influences both the short-term (seismic) and long-term (million-year) mechanical behavior of the subduction interface. The underlying basis of this hypothesis is the possibility that sediments exhibit fundamentally different frictional and viscous properties than subducted mafic oceanic rocks— specifically that sediments are weaker at all conditions along the plate interface. To test this hypothesis, I have split my approach into three complementary and carefully linked tasks, including Task I. Observations from Exhumed rocks, Task II: Rock Deformation Experiments, and Task III: Numerical Modeling. Task I will involve field geological campaigns in three sites representing different conditions of the plate interface, from shallow to deep. Task II will involve three suites of experiments (closely linked to the field sites) aimed at quantifying the rheological properties of mafic rocks at different pressure-temperature conditions. Task III will involve two types of numerical models: 1) seismo-thermo-mechanical modeling aimed at assessing the influence of heterogeneity on seismic slip behaviors, and 2) large-scale mantle convection modeling aimed at quantifying relationships and feedbacks between subduction interface rheology and plate speeds. This research has high potential to impact a number of Earth Science and related disciplines: establishing a lithological control on plate boundary strength, and hence on both subduction seismic behaviours and plate speeds, would establish a fundamental link between plate tectonics, climate, and life on planet Earth.


**Keywords:** Subduction zones, rheology, rock mechanics, mantle-surface connections, plate tectonics, field geology, microstructures, experime
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Next-generation AAV vectors for liver-directed gene therapy' to be submitted under Horizon Europe.

assistant: **Abstract**

Liver-directed gene therapy has undergone significant development in the last two decades. Recombinant adeno-associated vectors (AAV) are the vectors of choice for liver gene transfer and have recently achieved remarkable successes in clinical trials. However, there are still large groups of patients who have limited access to therapy. The major hurdles toward expanding the indication of AAV-mediated liver gene therapy are: i) transient AAV-mediated expression in proliferating hepatocytes, i.e. newborn or regenerating livers, due to dilution of episomal AAV genome in proliferating cells; ii) dose-dependent hepatotoxicity and immune response against AAVs; and iii) pre-existing immunity to AAV capsids, which currently preclude its systemic delivery in about 50% of individuals. AAVolution gathers renowned European experts in the field of AAV vectorology, gene therapy, genome editing and immunology, with the ambitious goal to develop and implement innovative therapeutic tools to effectively address these challenges. To this aim AAVolution proposes: i) to seek novel small Cas nucleases for in vivo AAV-mediated genome editing ii)to develop self-replicating episomal AAVs to avoid transgene dilution in proliferating livers; iii) to generate synthetic AAVs characterized by enhanced potency and reduced toxicity, by screening of novel AAV capsid libraries; iv) and to develop improved technologies to overcome pre-existing immunity to AAVs by transiently reducing the levels of circulating anti-AAV neutralizing antibodies.AAVolution will significantly expand the toolkit for AAV-mediated liver gene therapy, developing novel and improved molecular instruments to address the most relevant hurdles toward safer and more effective therapies, and provide access to treatment to patients that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Java Environment for Parallel Realtime Development', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The JEOPARD project will develop a platform independent software development interface for complex multicore systems, including SMP. The interface will be based on existing technologies including Java, the Real-Time Specification for Java (JSR 1 and JSR 282) and Safety-Critical Java (JSR 302), which provide a good foundation for the development of complex, safe, realtime systems, but do not yet provide particular support for multicore systems. Even worse, some technologies can not support more than one processor, making it impossible to develop applications that scale with the number of processors available on current and future advanced multicore systems.<br/><br/>The JEOPARD consortium covers all layers of a multicore embedded system. At the processor level, virtualised SMP architectures and advanced NUMA architectures are addressed. At the OS level, required OS scheduling facilities and low-level OS APIs will be provided for the virtual machine, or low-level native application code. JEOPARD will also analyse the impact of NUMA on OS facilities and how FPGA-based components can integrate with OS-supported components. At the Java virtual machine level, a realtime Java implementation that supports predictable execution of all Java operations will be extended to maintain predictable execution on multiple parallel processors, including real-time memory management, and support for efficient synchronisation mechanisms and compiler support for parallel systems. At the API layer, a powerful interface will be provided that provides control over and efficient use of available processor resources. Tools for static analysis of parallel applications will also be developed for detection of runtime errors. The project includes close involvement and validation by industry user partne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Biopterin-based inhibitors of nitric oxide synthase' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Excessive NO causes tissue damage in diseases of unmet medical need such as stroke, arthritis and diabetes. Induction of Type II NOS contributes importantly to cytotoxicity and bystander damage in these pathological states. Current inhibitors are mainly arginine mimics and show limited selectivity for type II NOS over the constitutive Type I and Type III isoforms and have side effects. Synthesis of inhibitors of the binding of tetrahydrobiopterin, a cofactor requires by the enzyme, by means of non-pterin moieties which also bind haem to provide a possibly unique selectivity signature" for NOS is proposed as a novel approach to selective NOS inhibition. Suitable leads are available in 7-nitroindazole and in phenylimidazole isomers, and data for pterins suggest that the tetrahydrobiopterin binding sites of the NOS isoforms may be distinguishable. In addition, because of its high level of expression, Type II NOS may be particularly susceptible to this form of inhibition."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A Theory of Neural Networks for Control' (NN4C) under Horizon Europe.

assistant: **Objectives**

As neural networks are delivering groundbreaking performance in various machine learning frameworks --- ranging from the basic framework of supervised learning to the powerful and challenging framework of control --- immense efforts focus on developing underlying mathematical theories.  Recent years witnessed breakthrough contributions to the theory of neural networks for supervised learning, by myself and others.  Yet, from a theoretical perspective, much is left to be elucidated about neural networks in the powerful framework of control, leading to a predominantly heuristic implementation, which hinders their use in control application domains where safety, robustness and reliability are critical, e.g. healthcare, aerospace and manufacturing. The overarching goal of the proposed research is to develop a comprehensive mathematical theory of neural networks for control, providing an explanative formalism for intriguing empirical phenomena, as well as breakthrough practical techniques that promote safety, robustness and reliability.  The research aims to overcome major current challenges by harnessing powerful mathematical tools in the realms of tensor analysis and dynamical systems theory, that I have developed over the past decade. Building on my academic record in the theory of neural networks for supervised learning, which is accompanied by vast practical industry experience with neural networks for control, I am confident in being uniquely positioned to pursue this pressing ambitious goal of developing a practical theory for neural networks in control.  A successful outcome of the research will significantly broaden the theoretical knowledge on neural networks, and unleash their power in critical control application domains, thereby having transformative impact.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A study for the technical and business feasibility of a fast-acting consumer test to detect gluten and other contaminants in food.' (RAD) under Horizon 2020.

assistant: **Objectives**

Due to the health risk for those suffering from Celiac Disease and other intolerances, Allogen Biotech Ltd.’s Rapid Allergen Detector (RAD) kits can detect a range of protein-based allergen in food or cosmetics, in a compact portable reader and disposable testing strips. The kits are versatile, with a cartridge-based reagent to identify and concentrate allergens for detection, and an accurate reader that can provide quantitative readouts for industrial users or a simple “traffic light” system for consumer model users. Results are available in 10 seconds or less, a reader can be used for over 10,000 tests, and test strips are simple to use, with a low cost.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A Wearable Electronics Approach To Reduce Mortality in Epilepsy' (NOSUDEP).

assistant: **Concept**

Epilepsy is a neurological condition that affects approximately 1% of the population (or over 50 million people in the world). Europe alone is home to 6 million people that suffer from epilepsy with one new case every minute. In certain cases, healthy patients with epilepsy can die suddenly and unexpectedly. This is known as Sudden Unexpected Death in Epilepsy (SUDEP). SUDEP kills thousands of people in Europe every year. Unfortunately the mechanisms of SUDEP are not known, which makes it unpredictable Individuals with refractory tonic-clonic or complex-partial seizures are at the highest risk of SUDEP. These comprise approximately one third of the population affected by epilepsy, i.e. in the order of 2 million people in Europe.The focus of this research project is to carry out multidisciplinary research on wearable medical technologies with the ultimate aim of helping to protect epilepsy patients from SUDEP, by automatically and reliably alerting carers of physiologically dangerous indicators that are known to be precursors of it. These technologies will also have the potential to facilitate clinical research that is not possible with existing physiological monitoring systems. This could further current understanding of the mechanisms as well as individual risks factors of SUDEP, and consequently lead to specific disease management, treatment and prevention strategies targeted to the individual patient. Additionally, the research work carried out in this project will be beneficial in a number of clinical contexts, including but not limited to: diagnosis of paediatric and adult sleep apnoea (affects 2-10% of the population, but less than 20% are diagnosed in developed countries due to lack of in-clinic resources), early warning scoring in hospitals (i.e. 80% of patients