RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Design of a frame work for producing and providing earth observation based information services for forest fires management at European and local levels'.

assistant: **Concept**

CONTROL-FIRE-SAT SUMMARY Forest fire management is a basic environmental activity with a big econornic and global climatic impact. In the southern Mediterranean countries is observed a high increase in the number and magnitude of the fires. Administration bodies expend large sums of money every year for planning and distributing the vigilance and extinction resources, but rarely they rely on space information. This project is addressed to introduce satellite information in the regular internal use of such management entities. To achieve this goal the proposal define a multinational and pre-operational scenario, progressively refined along two sumrner seasons, with real users involved in the partnership. Starting from a careful analysis of the present needs of the users and their associated internal decision making processes, three regular EO derived information products will be initially established and tested. Technical steps are based on AVHRR data. Their conversion to information are proved methodologies coming from another Environment and Climate Project denominated MEGAFlReS. Nonetheless, some complementary research activities have been foreseen in order to reach better results. At the same time, research partners will define scientific and technical standards so that defined EO product may become pre-operational EO services. Production environment is designed upon daily updated information. The task will use direct receiving, processing and disseminating facilities inside the consortium. The evaluation of the EO impacts in the activities of the users will be done independently from the production partners, to get unbiased estimations and the right path to future operational products. Finally, a consistent dissemination plan of the results has been planned in order
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'From CO2 and Nitrogen fixation to the delivery of therapeutic enzymes: Silicified DNA origami as artificial microcompartments'.

assistant: **Objectives**

All life is dependent on enzymatic reactions and functional enzyme cascades have been evolutionary optimized. Yet, introducing “foreign” enzymes into other organisms through genetic engineering often results in reduced or no enzymatic activity. In nature enzymatic activity and efficiency are often enhanced by encapsulation of enzymes in microcompartments resulting in protection and rate enhancement through high local concentrations of enzymes, co-factors and substrates. In NanoCat I will engineer artificial microcompartments hosting highly efficient enzyme cascades that are operational in organisms where they do not naturally occur. The approach is based on my recently developed method to controllably template silica nanostructures by DNA origami. These inorganic materials retain the attractive features of DNA origami like precise localization and number placement of proteins of interest. Combining the power of DNA nanotechnology with the sturdiness and biocompatibility of silica as artificial enzyme-hosting microcompartments, I now have a highly disruptive tool at hand that has the power to outperform standard biological methods and be a true game changer. NanoCat is a novel approach to assemble complex enzymes outside of their natural environments to address health issues, global carbon emissions and plant fertilizers, something that current biological methods struggle to do. The immense demand in today’s agricultural, climate and health needs urgently calls for engineered systems with full control over size, shape and functionalizability to enhance enzymatic activity and endow organisms with new and improved properties. NanoCat aims to provide a solution to these issues through the assembly of artificial enzyme-hosting microcompartments from silicified DNA origami wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Suppresion of adaptive immunity by the Salmonella effector SteD'.

assistant: **Concept**

In this project, I propose to characterize the influence of SteD, an effector of a globally important bacterial pathogen Salmonella enterica, on T cell development, and its potential therapeutic application. In the mouse model of S. enterica infection, the onset of the specific immune responses is delayed significantly in comparison to other bacterial pathogens. Recent work by the group of Prof. Holden, who is the supervisor of this project, a world leader in the field of Salmonella pathogenesis and the Director of the MRC Centre for Molecular Bacteriology and Infection (MRC-CMBI) at Imperial College London, identified SteD, an effector of the  Type III Secretion System (T3SS) encoded by Salmonella pathogenicity island 2 (SPI-2), as the first example of a virulence factor that reduces surface-localised mature Major Histocompatibility Complex class II (MHCII) levels in Dendritic Cells. In addition, I have found an increased activation of T cells following infection of C57BL/6 mice with S. enterica serovar Typhimurium (STm) ΔsteD mutant in comparison to wild-type STm, thereby showing that SteD is an important modulator of adaptive immunity in vivo. SteD and/or its gene have a high chance of having therapeutic application. I also have obtained preliminary evidence indicating that SteD has additional functions in the manipulation of antigen-presenting cells.  Therefore, I propose to use both the acute and chronic mouse models of Salmonella infection to further characterize the influence of SteD on T cell development. Furthermore, I will investigate the mechanistic and physiological significance of natural variation in the amino acid sequence of SteD among a broad range of S. enterica serovars, including the typhoid fever-causing human-adapted serovars Typhi and Paratyphi. F
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pricing with Big Data' in the context of a Horizon 2020 call.

assistant: **Objectives**

Will there exist price convergence in the online marketplaces? Is the economy shifting to a form of uniform pricing (each user observes the same price) or to a form of personalized pricing (discounts or prices are specific to groups of consumers)? From a managerial standpoint: What are companies’ optimal pricing strategies? What are the optimal frequencies of price changes? What is the optimal personalization? From the consumer standpoint: What are the behavioral reactions? What are the fairness concerns to those strategies? The research supported by this grant will allow to address these questions. The research lies in the intersection of pricing and big data using data from two main sources: data collected from online marketplaces; and data obtained from field experiments in partnerships with leading European retailers. The study of pricing and big data are core priorities for government agencies in Europe and the United States. For instance, big data is one of the five priorities under the “Digitizing European Industry” initiative and of Horizon 2020. The research will extract concrete implications. For academics, the development of advanced pricing optimization. For managers, the implementation of pricing algorithms in collaboration with academics that incorporates consumers’ concerns. And for policymakers, the understanding and thereby design of policies that regulate and increase price transparency, in a world where the barriers to using personalized data are increasingly complex.


**Keywords:** Consumer Behavior, Price Transparency, Big Data, Machine Learning, Industrial Organization, Optimal Pricing, Consumer Fairness, Offline and Online Markets
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Angelo Clareno (ca. 1260-1337) as a marginal Translator of the Greek Fathers : Circulation of Texts and People in Europe before Humanism' under Horizon Europe.

assistant: **Concept**

TRANSMAR aims to provide innovative perspectives and knowledge on the introduction, appropriation and circulation of the thought and texts of the Eastern Fathers in the West before Humanism and contribute to break the myth of the medieval ignorance of Greek. The project focuses on one marginal and emblematic translator, the Italian Franciscan dissident Angelo Clareno (ca. 1260-1337), best known as leader of the so-called fraticelli, persecuted all his life by the ecclesiastic authorities, and several Greek patristic texts that were first translated into Latin between the late 13th and early 14th centuries. Some of these, which have a long lasting influence on Western Christian spirituality until the Renaissance, were translated by Clareno himself, especially during his forced exile in Armenia and Greece. The others are attributed to him. By establishing and analysing the manuscript tradition of each of these translations TRANSMAR’s purpose is to understand how these Eastern patristic texts were introduced in the West for the first time and to evaluate their socio-cultural impact. By studying how and by which networks texts translated by a representative of a minority religious group spread, the project also aims to reflect on the social function of minorities in the long term. Based on a resolutely interdisciplinary approach, at the intersection of philology, manuscript studies, history of religion and spirituality, history of dissent/minorities, medieval translation, TRANSMAR is intended to determine the texts actually translated by Clareno, to investigate the circumstances of their composition, to map their circulation in Europe and to identify the networks through which they circulated.


**Keywords:** Latin Philology, Byzantine Philology, Medieval Translation, Manus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'MULTI-SOURCE AND MULTI-SCALE EARTH OBSERVATION AND NOVEL MACHINE LEARNING METHODS FOR MINERAL EXPLORATION AND MINE SITE MONITORING' in the context of a Horizon Europe call.

assistant: **Objectives**

The Multi-source and Multi-scale Earth observation and Novel Machine Learning Methods for Mineral Exploration and Mine Site Monitoring (MultiMiner) project develops novel data processing algorithms for cost-effective utilization of Earth Observation (EO) technologies for mineral exploration and mine site monitoring. MultiMiner unlocks the potential of EO data, including Copernicus, commercial satellites, upcoming missions, airborne and low altitude as well as in situ data, to support the entire mining life cycle including mineral exploration, operational, closure and post-closure stages. This is achieved by creating generic but highly innovative machine learning solutions which do not require any or only little ground truth data. The project focuses on new EO based exploration technologies for critical raw materials (CRM) to increase the probability of finding new sources within EU thereby strengthening the EU autonomy in the area of raw materials. MultiMiner EO based exploration solutions have extremely low environmental impact, and are thus socially acceptable, economically efficient and improve safety. The projects solutions for mine site monitoring increase the transparency of mining operations as environmental impacts can be detected as early as possible and digital information of the currently unexploitable raw materials can be stored for future generations. The applicability of the developed algorithms is demonstrated in 4 European test sites. MultiMiner is a pan-European consortium consisting of 12 partners and 1 associated partner from research institutes, academia, consulting businesses and mining industry with interdisciplinary backgrounds in geology, remote sensing and machine learning. The members come from six EU member states which represent mining region
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Geographical extension of the gem-e3 general equilibrium model database (DAT-GEM-E3)' to be submitted under Fifth Framework.

assistant: **Abstract**

The general objective of this project is to extend the geographical dimension of the database of the general equilibrium model GEM-E3 to cover most accession countries and to model more explicitly the Rest of the World by separating it into developed world outside Europe, the oil producing countries and rest of the world. The economic data to collect include national accounts data and Input-Output tables to be integrated into a Social Accounting Matrix for each country/region and the trade flows between countries/regions individually and bisector. These data will be complemented with R&D data on innovation and spill over effects. The energy and environmental data cover energy balances, emission coefficients, emission transport and transformation parameters and damages of all major pollutants linked to energy use. Data on energy technologies will be added to the Swiss database.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fast Infrared Coherent Harmonic Microscopy' to be submitted under Horizon 2020.

assistant: **Abstract**

The emergence of innovative research avenues in biomedicine in the last decades (cell therapy, cancer immunotherapy, bio-nanotechnology) has led to many proof-of-principle demonstrations fostering the hope for new therapeutic strategies for diseases. However, the translation from a laboratory bench into clinical practice has often proven unproductive. One of the reasons for this failure in translation is in the absence of imaging instruments capable of encompassing both the subcellular length-scale, where pathogenic disorders are set in, and that of tissues with differentiated cell types required to organize spatial and temporal functionality. An instrument enabling translation should allow resolving three-dimensional features within this large spatial range and operating with the same physical observables at each length scale, also enabling millisecond temporal resolution to monitor relevant processes. These requirements are essential to elucidate the hierarchical and temporal connections between micro and macro structures and events. Multiphoton microscopy has a yet undiscovered potential to fulfill these needs. FAIR CHARM aims at bringing this technique to its full capacity by i) providing access to millimetre imaging depths by building  a microscope (SWIM) with excitation in the Short-Wave Infrared Region relying on new laser sources, optimized optics, and ad hoc labelling probes; ii) enabling  unprecedented acquisition frame-rates (kHz/s) by the Spectro-temporal Laser Imaging by Diffracted Excitation (SLIDE) approach; iii) adapting Deep Learning recognition algorithms to multiphoton observables. The consortium features photonics innovators, worldwide renown enterprises in laser technology and microscopy, and clinical and biomedical end-users selected within the onc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Dissecting the Molecular Mechanism of Catastrophic DNA Rearrangement in Cancer'.

assistant: **Objectives**

Recent cancer genome analyses have led to the discovery of a process involving massive genome structural rearrangement (SR) formation in a one-step, cataclysmic event, coined chromothripsis. The term chromothripsis (chromo from chromosome; thripsis for shattering into pieces) stands for a hypothetical process in which individual chromosomes are pulverised, resulting in a multitude of fragments, some of which are lost to the cell whereas others are erroneously rejoined. Compelling evidence was presented that chromothripsis plays a crucial role in the development, or progression of a notable subset of human cancers – thus, tumorigensis models involving gradual acquisitions of alterations may need to be revised in these cancers.Presently, chromothripsis lacks a mechanistic basis. We recently showed that in childhood medulloblastoma brain tumours driven by Sonic Hedgehog (Shh) signalling, chromothripsis is linked with predisposing TP53 mutations. Thus, rather than occurring in isolation, chromothripsis appears to be prone to happen in conjunction with (or instigated by) gradually acquired alterations, or in the context of active signalling pathways, the inference of which may lead to further mechanistic insights. Using such rationale, I propose to dissect the mechanism behind chromothripsis using interdisciplinary approaches. First, we will develop a computational approach to accurately detect chromothripsis. Second, we will use this approach to link chromothripsis with novel factors and contexts. Third, we will develop highly controllable cell line-based systems to test concrete mechanistic hypotheses, thereby taking into account our data on linked factors and contexts. Fourth, we will generate transcriptome data to monitor pathways involved in inducing chromothripsis, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Perspectives of plant protein use in aquaculture: biological, environmental and socio-economic consequences', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

OBJECTIVES AND EXPECTED ACHIEVEMENTSThe final objectives of the project are to create conditions for the best utilization of plant protein sources in aquaculture feeds. The underlying objective is to strengthen and sustain the development of European aquaculture by reducing its reliance on fishmeal, derived mainly from the exploitation of marine natural resources.Although much progress has been made in the partial replacement of fishmeal by a number of ingredients with variable degrees of success, consolidation of such discrete scientific findings is required using multiple criteria, with an adequate trans-disciplinary approach. While feeding fish with fish has been decried justifiably by all as a non-sustainable approach, practically since the early days of aquaculture, there are also misgivings about producing vegetarian" fish which have theoretically carnivorous feeding behaviours under natural conditions."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Days of Socio-Economy: Education, Employment, Europe'.

assistant: **Concept**

An international conference with interactive workshops, entitled Education, Employment, Europe is to be organised for researchers, policy makers and practitioners, specialised in employment and educational fields. Outcomes of EU-funded projects from both spheres are often not sufficiently recognized and applied while their results should interact and improve/shape the economy, especially the labour market. The researchers in the socio-economic area will be involved to drive their attention to emerging problems and focus their interests on the perspective of approaching 7 FP. Presentations from research project clusters are foreseen followed by interactive workshops to receive feedback from practitioners and formulate recommendations towards researchers themselves, policy makers, and the European Commission.Workshops will be focused on:(i) active ageing,(ii) disabled in education and on the open labour market,(iii) quality vs. inequality in education and on the labour market,(iv) citizenship versus education and employment.Target audience will consist of representatives of relevant authorities and education/social workers mainly of regional level, but also central and local levels. The participants will represent EU member states but also associated and candidate countries. Conference proceedings will be edited in printed version; special web page will be created, functioning as a repository of all relevant documents.