RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Protein factory for kinase substrate searching and protein detecting micro-array development' (PROFACT).

assistant: **Concept**

After decoding the genomes of several living organisms, the main interest of biologists is focused on protein studies. This new field of biology -the proteomics- is signified by large-scale protein analysis and needs high-throughput approaches. Progress of the proteomics studies are largely depends on availability of sufficient amount of a large number of proteins. Presently, the protein production is cumbersome and has to be optimised on case-by-case basis. We aim at delivering solution for this bottleneck of proteomics by devising a 'protein factory'. Elimination this rate-limiting step speeds up the proteomics research. We exploit the 'protein factory' in two applications, first, to devise a general substrate hunting protocol; second to invent protein-detecting micro-arrays (PDM). Identification of protein kinase substrates is a major challenge of the post-genomic era and requires improved methodologies. Despite several efforts with different methods the identification has been slow and intricate.We describe a feasible protocol suitable for high-throughput substrate screening in any organism. We use this protocol for identification of plant kinase substrates involved in pathogen responses; hence, the expected results help understanding this agriculturally important process. PDMs are the protein sensors of future and could be used -besides basic science- in human diagnostic, food industry and environmental sciences. Development of these chips requires ample amount of assorted proteins, which could be conveniently produced with our system.During my training, I participated in European and national projects and established essential connections. The complexity of research objectives needs dedicated experts from a number of field therefore urge cross-border and national
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Blockchain Innovation Spaces'.

assistant: **Concept**

For the EU economy to grow sustainably it needs to re-industrialise, leveraging innovation and digital intelligence. Blockchain Innovation Spaces (Block.IS) envisions to build an open and collaborative cross-border, cross-sectoral innovation ecosystem that fosters the use of this cutting-edge technology in three vital sectors for the European economy: agrifood, logistics and finance. Block.IS will bring together (connect) actors (with an emphasis on SMEs and clusters) from these three heavily interconnected sectors, with SMEs/ innovators, to catalyse their cooperation towards innovation-driven and mutual growth (boost). The catalysation is aimed at networking the members of the ecosystem, raising understanding of the benefits of blockchain technology and stimulating the creation of new blockchain-based solutions - Cluster Missions and Clusters-Innovators Assembly. Block.IS will support innovators (SMEs) all the way from ideation to commercialisation offering them tailored business and technical support as well as direct funding, through a novel funnel approach - Innovate > Experiment > Commercialise acceleration programme. As such, the project will directly foster and strengthen competitiveness of digital SMEs (that will develop the solutions) and of the clusters and SMEs of the three verticals which will use them to offer added value to their customers.The Block.IS consortium is a fusion between: Tech founders and SMEs community (F6S), sector-oriented clusters and sectoral associations (VOICT, FEDACOVA, IT-Log, DSME, FTS), international innovation and Tech-transfer specialists (INO, IDI, CIVITTA, SYN) and Blockchain tech experts (INTRA, TNO); with an outreach of >1,017,000 SME.Block.IS invests 81% of the EC budget in SMEs and 51% through Open Calls (€2,800,000)


**Key
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrated Ecological Coastal Zone Management System' (ECOMANAGE) targeting Sixth Framework.

assistant: **Abstract**

Ecologists and social scientists have only recently realized that in order to fulfil the requirements for sustainable development, human beings have to be explicitly incorporated as structural components of ecosystems. Indeed, the clear distinction between natural and managed ecosystems is slowly fading-away, leaving us with the task of re-writing ecological theory in order to incorporate anthropogenic pressure. New concepts, necessary to understand these eco-social systems, will be assessed in this project, based on a modular approach to ecosystem modelling. This approach comprises physical and ecological models for computing transport and biological activity in the aquatic system. Anthropogenic influence on the drainage basins, determined by satellite data and models for ground and surface waters, will be translated through boundary fluxes to the aquatic system. These tools will cover problems and key issues identified in study areas. Environmental state and impacts will be translated into indexes to be incorporated on a spatial decision support system backed in the DIPSR decision framework. Local stakeholders will help establishing study scenarios and indexes for social-economic analyses. The project will focus on three different coastal zones.These sites include an estuary with mangroves in Brazil, a fiord in Chile and a large estuary with wide intertidal areas in Argentina. These systems host very important economical activities (including two important ports) and have been studied by major universities and/or research institutes in the respective countries. The major products of the project are: a knowledge base on estuarine and basin management, for answering basic to intermediate level questions, and a spatial decision support system to provide guidelines for re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Brain functional and anatomical correlates of variability in the degree of success in the learning of the L2 phonemes' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Economic and cultural globalization has turned the learning of foreign languages into a socioeconomic need. For that reason, the learning of at least one foreign language is a compulsory subject in the academic curriculums of most countries in Europe and around the world. One of the greatest difficulties for the learners of second languages (L2) is to accurately produce and perceive the speech sounds (phonemes) of the new language and, despite educational efforts of foreign language programs, few individuals manage to achieve high proficiency levels in these skills. The present study aims to investigate the functional and anatomical brain correlates of variability in the degree of success in the learning of the L2 phonemes.Our research question will be addressed by investigating (i) functional, (ii) morphological, and (iii) functional connectivity differences between good and poor perceivers of the L2 by means of magnetic resonance imaging (MRI). Individual differences in the learning of the L2 sounds will investigate all the levels of the phonological processing hierarchy (i.e., processes that cover auditory-sensory analysis, speech analysis, and attention) involved in producing and perceiving native phonemes.The results of this research are not only relevant because they will enhance our knowledge about how the brain processes and learns languages but also because they have the potential to help in the development of efficient language teaching programs.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'INtegrating MainSTREAM Economic Indicators with those of Sustainable Development'.

assistant: **Innovation**

Though mainstream economic measures such as GDP are useful measures with great influence on both public and private decisions, they are flawed as measures of human welfare. In addition, they give little information as to whether the market is helping Europe make progress on its environmental goals and its commitment to sustainable development. There is a critical need in Europe for indicators and measurement systems that—working in conjunction with mainstream economic indicators—provide a useful measure of progress toward economic success, human well-being, environmental protection and long-term sustainability. There is now a growing interest and momentum on the part of policy makers and researchers in developing these complementary headline indicators to better assess progress. The IN-STREAM project will undertake the qualitative and quantitative assessments necessary for linking mainstream economic indicators with key well-being and sustainability indicators, providing needed insight into the synergies and trade-offs implicit in Europe’s simultaneous pursuit of economic growth and environmental sustainability. Based on qualitative and quantitative analyses, recommendations for new indicator approaches will be proposed. Recommended indicators (and sets of indicators) will those that perform best in terms of their robustness, feasibility and suitability to EU policy objectives. Strategies for implementing these approaches will be identified and developed in consultation with stakeholders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development and validation of integrated multiprocess HYbrid PROduction CELLs for rapid individualized laser-based production' to be submitted under Horizon 2020.

assistant: **Abstract**

Individualised production is an emerging trend in manufacturing. Laser-based Additive Manufacturing (LBAM) fits well with this trend, due to its capability of transforming digital designs directly into physical products. LBAM is not yet competitive for a widespread industrial adoption: post-processing operations are necessary and they are not currently integrated, human intervention is needed to overcome technology gaps, and a poor integration with production planning systems hinders process traceability and resource optimisation. HyProCell proposes the combination of available cutting-edge LBAM machines and ICT innovations within an integrated multiprocess production cell, which will include at least LBAM and subtractive manufacturing machine/s, in order to ensure a fully finished product from the incoming raw material. The general objective of HyProCell is to implement and validate this concept in real settings, manufacturing real parts and measuring obtained benefits. HyProCell is expected to produce a sound impact on all the stakeholders of LBAM-related industry:- Making feasible a demand-driven LBAM production process supported on fast manufacturing procedure development capacities;- Creating highly automated and integrated multiprocess production cells, thus reducing dramatically downtime.- Enabling the rapid reconfiguration of the production cells, for scalability and/or new product demands, thanks to their modular architecture.- Fully enabling end-users to address new production trends.Relevant technological impacts are expected on hardware and software levels. A well-balanced consortium representing from machine manufacturers and end-users to Photonics experts, industrial automation specialist, ICT for smart manufacturing providers and technical services assure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Understanding The Role of the defects to Accomplish high Performance and Stable Two Dimensional Devices' (TRAPS-2D) targeting Horizon 2020.

assistant: **Abstract**

Dr. Marquez proposes a new approach to improve the performance of 2D materials: the defect-engineering. This approach aims to investigate the critical issue of defects implication on the 2D semiconductors operation to solve the low performance and to accomplish a future CMOS co-integration. Electrically activated interfaces, surface and oxide states have demonstrated not only to reduce the device performance but also making the device to behave in a determine operation. Surface defect have shown metal workfunction pinning and therefore formation of Schottky barriers at the contact-semiconductor interface. In addition, depending on the energy level these defect, they can contribute like donor or acceptor dopant or like generation-recombination (trap) centers. In this regard, the fabricated devices would operate differently, presenting n-type, ambipolar or p-type behavior and accumulation or inversion operation modes. Fast operating, normally-on or normally-of devices can be addressed controlling the defect implications. The understanding and control of these defect states and impurities in 2D semiconductor systems is an essential area of research, and the first step is to develop the metrology tools to accurately quantify defect densities and distributions gaining further insight into the possible origin of the defects states. “TRAPS-2D” is a proposal to systematical study of defect (trap) states implications on 2D materials. Its novelty resides in the control of these defects to force the fabricated devices to operate in a specific mode and therefore control their performance. Additionally, the proposal holds an important technological transfer aspect considering the co-integration of these 2D materials in the standard CMOS processes to open the doors to ultimate commer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Linking genotype to phenotype -  Role of diet on sex-specific reproduction'.

assistant: **Objectives**

Males and females perform different reproductive roles and have adapted to these by evolving sometimes strikingly different phenotypes. A key means to observe and understand differences is to examine metabolism, with studies being able to link differences in diet composition to varying levels of phenotypes. In spite of the clear dimorphism observed across the animal kingdom, both sexes are locked into a struggle over adaptation, rooted in the fact that both sexes share an almost identical genome. Here, I propose to combine high-throughput phenotypic approaches (including quantitative genetic tools), with cutting-edge genome expression data to identify genes and genetic pathways that are involved in metabolic conflict. My first aim is to explore whether males and females differ in dietary preference using Drosophila melanogaster as a model organism. I will establish the extent to which genetic correlations between male and female food preferences constrain the evolution of optimal diet choice. Consequently, my second aim is to identify genes and/or genetic pathways that are responsible for differences in diet preference, and limit the dietary adaptation. Finally, I will use state-of-the-art genetic manipulations to enhance/suppress parts of the genetic pathways involved in metabolism, and will examine if these genetic modifications bring sex-specific consequences to the physiology of the organism. Understanding the genetic basis for sex differences in metabolism will aid to build complete understanding of the differences between males and females at the cellular level and provide insight into dietary and metabolic influences as well as aid human health research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Smart City performance measurement system' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The European Commission has developed two parallel approaches to support the implementation of smart urban technologies: the creation of 'lighthouse projects' (large scale demonstration of technology in cities and communities) and 'horizontal activities' to address specific challenges (e.g. regulatory barriers, in standardisation, public procurement and performance monitoring). CITYKEYS project is within the context of these horizontal activities. The mission of CITYKEYS is to develop, and validate, a holistic performance measurement framework for future harmonized and transparent monitoring and comparability of the European cities activities during the implmeatation of Smart City solutions. The work methodology will be based on the following key factors:• Extensive collaboration and communication with European cities. • Establish a baseline by analysis and integration of existing results from previous initiatives.• Develop a set of KPIs specific for Smart Cities initiatives evaluation and comparability• Smart solutions for transparent and open data collection and processing.The tangible objectives of the CITYKEYS project are to:1) Develop and validate a transparent performance evaluation framework: including KPIs definition, guidelines for data collections, performance system prototype and testing in case-cities.2) Develop recommendations for the implementation of the performance system into the cities decision-making process and recommendations for the development of new business.3) Engage stakeholders in identifying and exploiting opportunities for synergy and replicability; and establish a collaboration platform for European cities.The consortium includes 3 multidisciplinary research organizations, 1 cities association and 5 partner cities covering different geograp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New players in the regulation of DNA replication fork speed' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Faithful eucaryotic cell division requires spatio-temporal orchestration of multiple sequential events. Among the crucial steps to providing the daughter cells with identical set of chromosomes is the DNA replication. During this phase, cells coordinate the speed of DNA synthesis with the length of the cell cycle to ensure genome integrity. To do so, growth factors and metabolic signals are integrated primarily by D-type Cyclins. Indeed. their deregulation can directly lead to some of the hallmarks of cancer by causing proliferation that is independent of normal extracellular cues. We previously demonstrated that aberrant accumulation of Cyclin D1 results in a faster cell cycle, with uncontrolled speed of DNA replication fork progression and genome instability (Maiani & Milletti et al., 2021). Despite, frequently altered in many tumors (Musgrove et al., 2011), a unifying theory that clarify how Cyclin D1 promote cancer transformation is still lacking. In the lab of Prof. Jiri Bartek, it was previously shown that PARP1 inhibition increases replication fork speed (Maya-Mendoza et al., 2018). PARP1i uncouples the leading and lagging DNA synthesis resulting in fast fork speed and genome instability. However, it is currently unknown whether the aberrant accumulation of Cyclin D1 has similar effect on DNA synthesis as PARPi. Furthermore, it is also undetermined whether aberrant levels of Cyclin D1 could trigger metabolic changes that accelerate the speed of DNA synthesis. Taking advantage of our previous observations, we aim with this proposal to: i) identify metabolic signatures that can predict dis-regulated DNA synthesis in response to cell cycle alterations; ii) define the molecular mechanism of how cyclin D1 accumulation induces accelerated fork speed; iii) identify new