RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Uncovering the Mechanisms of Cardiomyocyte Differentiation and Dedifferentiation' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The quest to restore damaged organs is one of the major challenges in medicine. Recent studies in both animals and in humans suggest that the heart has a limited capacity to replenish its own cardiomyocytes (CMs) throughout life, albeit inadequate to compensate for major injuries such as acute myocardial infarction (MI). Most therapeutic research in regenerative cardiogenesis is geared toward stem cell therapy as a means to replace lost CMs associated with ischemic heart disease. Clinical data evaluating the efficacy of cell-based therapy for heart disease are relatively disappointing. This proposal encompasses multidisciplinary and novel approaches to study the molecular and cellular mechanisms that govern the proliferation, differentiation and dedifferentiation of endogenous CMs, combining developmental-, systems- and cell-biology methodologies in vitro and in vivo, in chick, rodent, and human tissue samples. First, we will perform combinatorial perturbations of signaling pathways in chick embryos, focusing primarily on the FGF-ERK pathway, to investigate the molecular switch between cardiac progenitors and CMs (Aim 1). Because adult CMs have limited proliferative capacity, mainly due to mechanical constraints, in Aim 2, we will apply state-of-the-art techniques in cell biology, to determine whether specific mechno-transduction stimuli can prime the proliferation of differentiated CMs. In order to gain deeper insights into the capacity of adult CMs to renew themselves under normal and pathological conditions, in Aim 3, we will employ a novel cell lineage methodology in mouse and human tissue, based on information encoded in genome. Using this methodology, we hope to shed light on the maintenance, renewal and regenerative capacities of adult CMs in vivo. The expected o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'INFOMIX: Boosting information integration' under Fifth Framework.

assistant: **Concept**

This project researches advanced reasoning capabilities to achieve powerful information integration. A theory and techniques for future information integration systems will be developed to handle semi-structured data in high-level, declarative interaction with the user. Computational logic provides promising techniques for reaching this goal, but scalability of the approach requires developing new optimisation techniques to enable efficient manipulation of large amounts of data. This project researches advanced reasoning capabilities to achieve powerful information integration. A theory and techniques for future information integration systems will be developed to handle semi-structured data in high-level, declarative interaction with the user. Computational logic provides promising techniques for reaching this goal, but scalability of the approach requires developing new optimisation techniques to enable efficient manipulation of large amounts of data.OBJECTIVESThe principal objective is to obtain an advanced system for information integration which is innovative in providing:- comprehensive information modelling;- advanced reasoning capabilities;- handling of semi-structured data;- declarative user-interaction;- handling of incomplete and inconsistent data sources.DESCRIPTION OF WORKInformation integration has the task of providing a uniform interface to various pre-existing data sources so as to enable users to focus on specifying what they want rather than thinking of how to obtain the answer. As a result, an information integration system frees users from the tasks of finding the relevant data sources, interacting with each source in isolation, and selecting, cleaning, and combining data from multiple sources. The project aims to provide a solid theory and innovati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Isolation, characterisation and immunological evaluation of recombi nant vaccines for filarial parasites' under Fourth Framework.

assistant: **Concept**

* Development of candidate vaccines against parasitic filarial infections, in particular Onchocerca volvulus.* To identify, isolate and express antigens that are specific to the larval stages of these parasites.* To analyse of the immune responses of humans exposed to O.volvulus and animals infected with Acanthoche lonema viteae to these antigens.* To assess the protective capacity of these antigens in a rodent filarial model system.Expected Outcome* The identification of novel candidate vaccine antigens for onchocerciasis.* The identification of the type of immune responses that are protectiveagainst filarial infections in humans and animal models.* Production of quantities of L3 and L4 larval stages of the parasites Onchocerca volvulus and Acanthocheilonema viteae.* Identification and characterisation of antigens that are specific to the larval stages of the parasite by protein analysis and differential display PCR.* Cloning and Expression of stage specific antigens from cDNA libraries of each larval stage.* Characterisation of the cellular and humoral responses to the larval antigens of putatively immune humans exposed to onchocerciasis transmisson.* Evaluation of the protective capacity of the recombinant larval antigens in a rodent filarial model system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Improving technical management in baltic cod fishery' (BACOMA).

assistant: **Innovation**

1. To provide quantitative measurements of dominant factors which cause variability in trawl codend selectivity in Baltic cod fishery, and to develop codend modifications and operational approaches that will improve trawl size-selection relative to present designs.2. To develop, test and apply improved methodology for estimating the escape-survival of cod under commercial fishing conditions, and to identify codend designs that may enhance survival.3. To develop a model for assessing biological and socio-economic consequences of improved selectivity in the Baltic fishing fleet.The top-panel window codends showed higher L50-values than the corresponding standard codends. In window codends a pronounced positive correlation was observed with L50 and selection range (SR). The confidence regions, however, were relatively large for the 125 mm and 135 mm window codends. The codend without the cover caught on average 15% more cod than the codend with the cover. The variation in catches between the hauls, however, was fairly large. The codend with the cover caught significantly less cod below 45 cm than the codend without the cover. The hauls made without the cover had a substantially larger variability in individual selection curves, and L50 and SR of the combined hauls were higher.A large between-haul and between-vessel variability in selectivity was obtained in vessel-size experiments. Vessel-size, however, was not found to have any clear effect on the L50.. On the other hand, indications were obtained that vessel hauling technology can be a potentially important factor causing variability in selectivity. The best selectivity in terms of L50 was found on a side trawler. This difference is likely connected to the duration the gear is slack during the haul-back. Indication of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Design, analysis and computation for catalytic organic reactions' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The Network will provide training in an area important both to industry and academia. The pharmaceutical and fine chemicals industries will be recruiting vigorously over the next few years as the effects of the Human Genome project impinge on drug development. Young chemists with a training in catalysis along the lines indicated in the proposal will be highly employable. In the Discovery sector catalytic methods are increasing in importance. Process departments may use catalytic methods as a first option in future, because of the favorable considerations of atom economy and waste management. These will play an increasingly important role as environmental considerations come to the fore in the European Chemical and Pharmaceutical industries. Hence the scientists trained through this RTN collaboration will be very attractive candidates for employment, and will also have an excellent basis for an academic career. They will have had contact with some of the leading aspects of contemporary catalysis, in well-found laboratories. The projects will have given them a range of skills alongside synthesis, and experience in different research environments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ubiquitin Signalling Pathways Required for Influenza Virus Replication: Biological Characterisation and Identification of Novel Drug Targets' to be submitted under Seventh Framework.

assistant: **Abstract**

Influenza viruses are a significant seasonal disease burden, and provide an ever-present threat of causing severe pandemics with potentially devastating clinical, social, and economic consequences. Vaccines and antivirals are available for the prevention and treatment of influenza. However, it often takes too long to manufacture, distribute, and administer an effective strain-matched vaccine under pandemic circumstances, while drug-resistant viruses often emerge against the approved antivirals. Thus, there is urgent need to develop new antivirals with lower chances of selecting drug-resistant strains.Influenza viruses rely extensively on host cell functions, therefore one way to minimise resistance is to target antivirals against host proteins required for virus replication. Here, I will investigate 10 cellular E3 ubiquitin and ubiquitin-like ligases with ‘druggable’ qualities that have been identified in genome-wide siRNA screens as potential host factors required for influenza virus replication. I will confirm their involvement in supporting replication of a broad range of influenza virus strains (including seasonal and pandemic viruses), and attempt to delineate their mechanism of action. By depleting cells of each E3 ligase, and using novel large-scale SILAC- and affinity- based quantitative proteomic techniques, I seek to identify global changes to the cellular ‘ubiquitin-ome’ during virus infection, and correlate these changes with specific host E3 ligases. My work should establish functional and mechanistic links between E3 ligases required for virus replication and the ubiquitin or ubiquitin-like modifications they cause. I hypothesise that there are specific modifications on cellular or viral proteins that are essential for virus replication. Understanding the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Impact of compensation on information acquisition and dynamic trading strategies' under Fourth Framework.

assistant: **Concept**

The research analyses how salary schemes affect the information acquisition and dynamic trading strategies of traders in investment banks. Conflict arises between the bank and trader because of informational differences and differing objectives. The agent's dynamic portfolio choice is modelled under continuous-time moral hazard with hidden actions and information. Several contracts are considered: first-best (where the trader has no informational advantage over the bank), bonus payments, linear share of returns, and quadratic contract. Contracts based on the whole return history over the compensation period are compared to contracts that only use end-of-period returns, as in static models. Related work on the agency problem between investors and fund managers models a continuous-time principal-agent problem where the agent controls both the drift and the volatility of a Markov diffusion representing an asset value or a profit stream.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced statistics for clearance of accounts (ASCA)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Specific Objectives1. Contribution towards harmonization of reports of Certifying Bodies. So far, the review of two reports of certifying bodies has revealed deviations in control and reporting practice as well as the transferability of practices between various Bodies certifying payments in identical budgetary lines in different Member States. Findings from an in-depth study of three reports of certifying bodies will be presented in a synthesis report with a view to the preparation of guidelines by DG-AGRI;2. Methods for the estimation of overpayment will be developed, implemented, applied and evaluated in auditing problems.3. After the request of the primary customer DG, the project team is expected to contribute to the review of chapters of the Operational Handbook for the Audit of EAGGF-Guarantee Expenditure.Planned Deliverables4. Reports reviewing four annual reports of Certifying Bodies with a view to the preparation of guidelines delivered to DG-AGRI;5. Report on Bayesian and classical estimation of overpayment in auditing applications delivered to DG-AGRI. Software implementing methods developed;6. Contribution to the revision of selected chapters of the Operational Handbook for the Audit of EAGGF-Guarantee Expenditure.Specific deliverables to DGs:As above.As a result of the research:Submission to a peer review journal with references to sectors and Member States appropriately masked.Summary of deliverables 2001: 31/12/20011. Arsenis, S., and A. Karvounaraki (2001). On Reports of Certifying Bodies with Particular Reference on Harmonization in Reporting. ISIS/RMDS/402 draft, to be finalized within 20.12.2001.The reports of two certifying bodies on two paying agencies in two different member States for exercises 1997 and 1998 were studied with an interest on the e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Flexible and PrecIse IrriGation PlAtform to Improve FaRm Scale Water PrOductivity' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The objective of the FIGARO project is to significantly reduce the use of fresh water on farm level through developing a cost-effective, precision irrigation management platform. The platform will be structured for data acquisition from monitoring devices and forecasting tools, data interpretation, system control, and evaluation mechanisms enabling full decision support for end users at farm scale. These tools will be integrated with multiple state-of-the-art irrigation technologies and strategies as well as newly adapted devices leading to further increased water productivity. The flexibility, cost-effectiveness, ease of use, minimal maintenance of the system and often, increases in crop yield, will boost its acceptance and up-take by the end-users (the farmers, extension workers). In addition, as added value the system will enable reduction of fertilizer use, further supporting sustainable use of natural resources and adaptation of agricultural practice to climate change. To achieve this, the FIGARO project will develop a holistic and structured precision irrigation platform which will offer farmers flexible, crop-tailored irrigation scheduling protocols for their specific fields taking into account spatial variability management.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Non-trAditioNal sTable mEtaL isotOPE (Fe, Mg, Zn) fractionation: a case study from the Bushveld Complex, South Africa', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Mafic layered intrusions, formed by the slow cooling and differentiation of basaltic magmas within the crust often contain enormous metallic ore resources, of vital importance for industrial and societal applications. The ca. 2.0 Ga Bushveld Complex in South Africa is by far the largest mafic layered intrusion on Earth, and contains > 80% of the world’s Platinum-Group Elements (PGE) and huge quantities of Cr, hosted within a few nearly monomineralic dense oxide layers which are continuous over 100’s of kilometers. Despite many decades of scientific research, the processes that resulted in the formation of these magnificent layering features and the accumulation of precious metals to such high concentrations are heavily debated. Part of the problem arises from the fact that compositional data suggests the influence of post-magmatic processes and fluid circulation operating in the magma chamber. Such processes are likely to have modified the primary cumulate pile and influenced precious metal distribution, but the extent to which these rocks have been subjected to subsolidus modification is not known. I propose to develop new geochemical tools to quantify the influence of these processes, using an unprecedented precise approach of Fe, Mg and Zn isotope measurements on ferromagnesian sililcates, oxides and sulfides. Not only will the results support further precious metal exploitation by expanding our understanding of the formation and evolution of mineralized oxide layers in the Bushveld, but they will also be of high scientific relevance for all applications of high-temperature stable isotope geochemistry across the fields of igneous and metamorphic petrology as well as geo- and cosmochemistry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Politics of humanitarian care: aid, displacement and social reproduction in Croatia' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The idea behind the REHUM project is that institutionalized practices of care are being replaced by emergency humanitarian aid, forming an ambivalent concept of humanitarian care. By using a participative ethnographic approach in two humanitarian settings – post-earthquake displacement and irregularized migration – the project will explore how and if the expansion of humanitarian initiatives in different emergencies points to the same problem of the erosion of institutionalized care while shedding light on ambivalent transformations of grassroots organizations and its employees/volunteers in their attempts to replace such systems. While previous research pointed out different aspects of social inequalities enhanced in and by humanitarian programs, the emphasis on the entanglements between humanitarianism and care in the context of migration/displacement in Croatia, especially regarding the phenomenon that political theorist Nancy Fraser termed “crisis of care”, has not been quite touched upon. In order to expand the critique of humanitarian care in Croatia, but also in a wider sense of the European (semi)peripheries, REHUM will theoretically and empirically explore the intersection between social reproduction, humanitarianism, and displacement. Starting from the assumption that care, understood as an essential part of life and a practice inevitable for human development, is structurally devalued and externalized to the area of household and informal aid initiatives, REHUM will aim to identify the ways in which humanitarianism in Croatia underpins that process while situating scarce state responses and their replacement with temporary humanitarian solutions in a broader political framework.


**Keywords:** humanitarianism, care, social reproduction, displacement, aid