RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European groundwater and contaminated land remediation information system' (EUGRIS) targeting Fifth Framework.

assistant: **Abstract**

This proposal outlines an Accompanying Measure to develop an European web based information management system (EUGRIS) on groundwater and contaminated land remediation. The management of this issue requires complex interdisciplinary expertise as well as a considerable amount of supporting technical information and knowledge. EUGRIS will be generally available and applicable providing a comprehensive and overarching information and innovation resource. The gateway will provide a one stop shop" for information provided by research projects, legislation, standards, best practice and other technical guidance and policy/regulatory publications from the EC, participating Member and Accession States and from various international networks dealing with groundwater and contaminated land issues."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Long-period observation of biological processes at Picosecond time resolution and Nanometre spatial resolution: a research-training network for advanced imaging Technology' (2002-2006).

assistant: **Innovation**

Based on novel technology developed in the framework of a new FP6 STREP project (STRP 013880) we propose to establish a multidisciplinary Research Training Network for training young scientists in advanced Fluorescence Microscopy techniques that will be applied to address a broad range of biological questions. Special emphasis will be put on Fluorescence Lifetime Imaging Microscopy (FLIM), a method of choice to study dynamic interactions of bio-molecules in the living cell, and its extension into the NanoScopy domain (FLIN). Young scientists employed in the network will further develop and apply these techniques to investigate the dynamics of individual molecules (Molecular Engines) as well as of complex cellular processes (Cell Imaging).The young scientists will have the opportunity to work and to be trained in up to eight European countries, being tutored by experienced local staff scientists. Inter-sectorial exchange of young scientists will be strongly promoted and the composition of the network with academic and industrial partners in the fields of physics, biology and engineering will ensure state-of-the-art training of next-generation scientific researchers possessing the broad, interdisciplinary skills necessary for innovative research that drives development both in economy and health care. This network will significantly improve the competitiveness of the ERA by expanding European human resources with young researchers skilled in the art and science of advanced nano-scale microscopy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The first predictive in vitro assay for the identification of respiratory sensitizers.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The GARDair project will optimize and validate the first predictive assay for respiratory sensitization and bring it to market. This innovative in vitro test builds on the successes of its forerunner – the GARDskin assay, which has been shown to hold the highest predictive power (89%) of skin sensitizers amongst all commercially available methods. The GARD technology offers an unparalleled way to make hazard predictions, as it uses a human dendritic cell line to monitor immunological responses to chemical exposure. This approach offers not only higher predictive accuracy than in vivo tests, but also eliminates the need for animal testing at the same time as it cuts costs and experimental time.The need for ethical, accurate and economical safety assessment procedures is growing in parallel with the amount of new chemicals introduced yearly into our environment by the pharma, cosmetics and chemical industries. In order to protect both workers and customers from chemically induced sensitization, EU legislation dictates that all chemicals must be sensitization tested within the next two decades. The EC and ECVAM have a leading role within the OECD to develop test guidelines for skin sensitization hazard identification. Similar steps have not yet been taken in the area of respiratory sensitization due to the lack of available test methods to identify such compounds. The GARDair assay thus holds the power to drive the EU regulatory framework by entering a globally uncontested market space. If successful, the project will allow SenzaGen to become a key player in any application of animal-free, cell-based systems, aiming to assess sensitization capabilities of various compounds and to fully realize its business development strategy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Analysis and Design of Earthquake Resistant Structures' in the context of a Seventh Framework call.

assistant: **Objectives**

Worldwide, major earthquakes have caused tragic catastrophes with unparalleled losses in human life and property where inadequate design and construction practices have been identified as the major culprit. Thus, for mitigating the seismic risk, high quality training and education of professionals and researchers in analysis and design of structures has become of paramount importance. The proposed Network aims at promoting the research cooperation on the design of earthquake-resistant structures by creating strong synergies between research and practice among six countries under seismic threat: Greece and Cyprus (EU), Chile, India and Mexico (S&T) and Armenia (ENP). Bridging the gap between the Earthquake Engineering and Computational Mechanics scientific communities with the exploitation of the scientific potential and the complementary expertise of human resources of the Network, the research teams will further deepen, strengthen and advance their activities by addressing five major disciplines of Earthquake Engineering: (i) Stochastic characterization of seismic ground motions, for simple and accurate generation of synthetic accelerograms; (ii) Modeling and analysis of structures under seismic loading, aiming to validate and advance the cutting edge of computational methods; (iii-iv) Reliability- and performance-based seismic design, working towards a fully probabilistic framework for holistic structural design; and (v) Analysis and design of base-isolated structures, addressing the needs of high performance designs for critical facilities. For each topic, training programs will be provided through joint workshops, participation in thematic conferences and attendance of a specialized international MSc course hosted at the coordinating institution. Combining such focu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LEADING THE FLOATING WIND MARKET DEVELOPMENT' (LEADFLOAT).

assistant: **Concept**

Offshore wind has emerged as a highly effective, cost competitive and a key contributor to the European energy transition challenge.Yet, current technologies limit offshore wind deployment to shallow water depth (less than 40m) restricting the market potential to a few countries (mainly the North Sea), while the vast majority and the best wind resources are located in deep waters. The installation of wind turbines on floating foundations inevitably appears as the future of offshore wind. Floating foundation solutions unleashes the market potential with no restriction on the water depth or on the seabed soil conditions, allowing developing projects further offshore where wind is stronger and the visual impact is limited.IDEOL, a French SME created in 2010, has emerged as one of the few international leaders in floating wind, with two demonstrators built in France and Japan, relying on its patented floating platform technology, the most cost competitive solution in the market. Its team, composed by more than 40 engineers, is globally recognized as one of the best technical team with a unique know-how and innovative approach. IDEOL is already engaged in different pre-commercial and commercial projects in France, Japan and California. It is the only European technology provider and the only foreign company having convinced the Japanese government and experts.Its technology is characterized by its extreme compactness and simplicity, its compatibility with the existing and the future extra-large wind turbines without modification, its construction either in concrete or in steel.LEADFLOAT aims to impose IDEOL’s solution as the market leader of floating wind by keeping its cost competitiveness advantage, leveraging on its demonstrators’ return of experience and securing early m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Valorization of Lactobacilli and their Antimicrobial Peptides for Reproductive and Intimate Health Enhancement' to be submitted under Horizon Europe.

assistant: **Abstract**

In an era marked by escalating concerns over antibiotic and antimycotic resistance as the next major global pandemic, the need to explore unconventional sources of antimicrobial agents has become increasingly urgent. In this context, lactobacilli, traditionally renowned for their probiotic and food applications, have recently emerged as a promising source of novel antimicrobial strategies. These lactic acid bacteria, abundant in various natural habitats including the human vagina and fermented foods, present a unique source for the discovery of novel antimicrobial compounds, because the compounds are valuable as such when purified and when combined with the producing lactobacilli are used as live biotherapeutic products or probiotics. The VALERIE project starts from recent discoveries in the host laboratory that lactobacilli from the vagina can produce specialized antimicrobials, including novel bacteriocin-types. This discovery is particularly appealing since gynaecology and womens health is an area in medicine which urgently needs new antimicrobials. VALERIE aims to bring these discoveries to a higher Technology Readiness Level (TRL4). Our objectives include purifying and characterizing these compounds and assessing their antimicrobial efficacy against key pathogens, including fungi like Candida albicans and ESKAPE pathogens and elucidate their mode of action. Hereto, we will assess the safety and efficacy of the purified compounds and producing lactobacilli in silico, in vitro and in vivo and initiate the development of multispecies lactobacilli formulation for applications with the live producing micro-organisms. These experiments will result in a robust dataset that can attract industrial partners for future endeavours aimed at clinical applications. Through innova
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced methods for assessing the seismic vulnerability of existing motorway bridges' under Fourth Framework.

assistant: **Concept**

Recent seismic events all over the world have shown that bridge structures are particularly sensitive to earthquake loading. There are several reasons for such sensitivity. First many existing bridges were designed without adequate consideration for seismic risk. This has resulted in inadequate detailing of confining steel and insufficient shear reinforcement in the bridge piers, insufficient seat length of bearings, and inadequate strength and stiffness of the superstructure-abutment connection. Furthermore, there are many open questions concerning the ductile behaviour of large bridge piers, in particular those with rectangular hollow cross-section. Also, the seismic zonation map of many European countries has been revised recently, prescribing now higher horizontal ground accelerations in several regions. Finally, local soil conditions and the possibility of asynchronous motion at the base of the piers of long bridges are factors which can cause additional difficulties in properly designing irregular bridges. There is therefore a need for reliable methods for assessing the seismic vulnerability of existing bridges, in particular large and irregular motorway bridges having lifeline character. It is the aim of the present project to give a significant contribution to the development of advanced methods for assessing the seismic vulnerability of bridges.To achieve this objective, an international team has been set up covering the following disciplinary tasks contributing to the seismic vulnerability issue: 1. Dynamic in-situ testing to identify the actual bridge properties including soil-structure interaction effects and characterise the surrounding soil; 2. Calibration of numerical models for predicting the linear bridge response (modal analysis), including support bou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Novel nano coating process to empower the green hydrogen revolution'.

assistant: **Concept**

Hydrogen is a major opportunity in the switch to an eco-friendly economy. Today, it is produced from fossil fuels with high carbon emissions. A green alternative is converting excess solar and wind energy into hydrogen via a water electrolysis process. Hydrogen produced in this process is very aggressive chemically, so electrolyser components need protection with advanced coatings. Currently, most widely used coating deposition methods are outdated and not scalable due to high production costs and usage of precious and scarce metals (e.g. of the platinum group).Naco Tech developed a breakthrough proprietary high-speed ion-plasma magnetron sputtering technology (HMS) that enables efficient application of various types of coatings. Our solution stands out with better coating quality which doubles the lifespan of electrolysers. It reduces usage on scarce metals by up to 10X, and ultimately lowers costs of green hydrogen.


**Keywords:** Green hydrogen,Nano coatings,Magnetron sputtering,Water electrolysis,PEM membranes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Reconstitution of CUPS in vitro and assessing the mechanism of their cargo packing during unconventional protein secretion'.

assistant: **Concept**

Most proteins secreted by eukaryotic cells use the endoplasmic reticulum (ER)-to-Golgi pathway of secretion. This is dependent on signal-peptide sequences that ensure protein translocation into the ER and their progress to the cell surface through vesicular flow via the Golgi apparatus. However, a substantial number of proteins that lack a signal-peptide sequence are secreted without entering the classical ER-to-Golgi pathway. Instead they follow the so-called “unconventional pathway of protein secretion”. A well established route within this unconventional pathway refers to cytoplasmic proteins transported to the extracellular environment by autophagosome-like vesicles, such as the Saccharomyces cerevisiae protein Acb1. Secretion of Acb1 in yeast cells is concomitant with the biogenesis of recently characterized membrane structures called CUPS (compartments for unconventional protein secretion) which are thought to function as a sorting platform for Acb1 secretion and possibly for other proteins known to follow similar routes of secretion. The overall aim of this proposal is to further characterize the biogenesis of CUPS in Saccharomyces cerevisiae and to understand their role in the unconventional pathway of secretion, i.e., to address the hypothesis that CUPS are sorting platforms for proteins to be unconventionally secreted. Determining the composition of CUPS, understanding their biogenesis and how their cargo is sorted will surely provide mechanistic insight on how Acb1 and other proteins, which include the inflammatory cytokine IL-1β or Galectin-3 in mammalian cells, are secreted.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Reinforcement of research potential for the realisation of a complete drug development scheme from natural compounds' (NATPHARMA) under Seventh Framework.

assistant: **Objectives**

The aim of NatPharma is the growth and the strengthening of the RTD potential of NeaNat, a multidisciplinary research group based in Campania, one of the EU’s convergence regions. NeaNat brings together the experience and the skills of two groups with a proven expertise in the fields of isolation and identification of natural compounds (NeaMARINE) and of computer aided drug design (NeaCADD). Both groups work in the same department (Dipartimento di Chimica delle Sostanze Naturali, University of Naples ""Federico II"").  The aim of NatPharma is to improve the effective capacities and research potential of NeaNat, granting the group the capacities for the successful realisation of a complete drug development scheme from natural sources to optimized drugs, including the identification, the clarification of the mechanism of action, the optimization and the biotechnological production of bioactive compounds from marine sources.  Albeit our worldwide scientific excellence in the fields of research we are involved, we need new expertise in the fields of: i) biotechnology for the identification of genes involved in the biosynthesis of bioactive compounds and ii) quantum-mechanical calculations (ab-initio methods) for the investigation of the interactions occurring between organic molecules (drug candidates) and biological targets containing metals. NatPharma will address these aims by means of i) two-way secondment of staff researchers, ii) recruitment of expert researchers, iii) participation at workshops and courses, iv) organization of seminars. These actions will be integrated by the upgrading of the research equipment. Moreover, the twinning with other EU-based institutes, and the promotional activities planned will also foster a better integration of NeaNat at the European
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Decision Support Tool for Rail Infrastructure Managers' (DESTinationRAIL), addressing dissemination and exploitation.

assistant: **Impact**

The project provides solutions for common infrastructure problems encountered in diverse regions of Europe, e.g. deterioration and scour damage to bridges, slope instability, damage to switches and crossings and track performance. Whilst similar failure modes are seen around the EU, the triggers (precipitation, earthquake loading etc.) are regional. The DESTination RAIL project will develop management tools based on scientific principles for risk assessment using real performance measurements and other vital data stored in an Information Management System. This will allow for a step-change in the management of European rail infrastructure. The objectives will be achieved through a holistic management tool based on the FACT (Find, Analyse, Classify, Treat) principle. Find - Improved techniques for the assessment of existing assets will be developed. Analyse- Advanced probabilistic models fed by performance statistics and using databases controlled by an information management system. Classify- The performance models will allow a step-change in risk assessment, moving from the current subjective (qualitative) basis to become fundamentally based on quantifiable data. Treat - The impact of proposed remediation or reconstruction will be assessed using the a probabilistic whole life cycle model which includes financial and environmental costs and the impact of work on traffic flow.The FACT principles will be implemented in a holistic decision support tool for infrastructure managers.DESTination RAIL will result significant impact in relation to the objectives of the work programme. It will reduce the cost of investment by using the IMS to manage the network, (ii)  Monitoring and real-times analyses will prevent unnecessary line restrictions and closures. (iii) Lower maintenan