RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mechanism of hydrogenation and transfer hydrogenation of polar unsaturations catalyzed by non N-H systems' (NONNH), addressing dissemination and exploitation.

assistant: **Impact**

The project addresses the reduction of polar unsaturations catalyzed by metal complexes under strongly basic conditions. This is an important reaction that enters the manufacture of many high added value fine chemicals. The role of the strong base for catalysts that do not contain active protons in the ligand donor functions is unclear, as well as the relationship between the mechanisms of hydrogenation by H2 and transfer hydrogenation. The sought mechanistic understanding can lead to the design of improved catalysts and operating conditions. The project will be implemented by a multifaceted approach that includes synthesis, characterization, catalysis, kinetics, and computations and be further enriched by parahydrogen NMR studies through a 3-month secondment at the University of York. This multisectorial training will put the ER on an excellent basis to further develop his professional career in research. The ER has an excellent basic training from one of the premier institutions in his Country and an outstanding publication record. The ER will be expected to mentor undergraduate students in the group, to deliver 4 presentations at group meetings, to present his results in at least one international conference and to contribute to drafting research publications. The project is expected to lead to high impact fundamental knowledge resulting in high quality publications, presentations at international conferences, and popularized articles in University magazines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project '6G Localization: The union of non-terrestrial, terrestrial networks, and RIS'.

assistant: **Objectives**

The surge in demand for precise localization services, driven by location-based applications and autonomous vehicles (AVs), necessitates advancements beyond current GPS and 5G technologies. 6G presents a transformative opportunity by leveraging non-terrestrial networks (NTNs), sub-terahertz terrestrial networks (TNs), and reconfigurable intelligent surfaces (RIS). NTNs extend cellular localization to remote areas through LEO satellite constellations. Utilization of sub-terahertz frequencies in TNs results in precise range and angle measurements, especially in complex urban environments. Finally, RIS enhances signal propagation by overcoming obstacles and extending the reach of NTNs and TNs. To this day, no unified framework exists for integrating NTN, TN, and RIS for localization purposes. The 6G-LUNAR project aims to bridge this gap to meet the stringent AV localization needs within the 6G-LUNAR paradigm. To do that, three work packages are set. WP1 focuses on developing a unified theoretical framework and a holistic simulation tool. WP2 derives the theoretical error bounds and conducts short-term and long-term system optimization. WP3 leverages the applicant's experience in sensor fusion algorithms to integrate NTN, TN, and RIS technologies. Various integration methods, including least-squares and Kalman filters, will be explored for snapshot localization and tracking. Loosely coupled and tightly coupled integration schemes will be evaluated and benchmarked against theoretical bounds using the simulation tool developed earlier. Realizing the 6G-LUNAR project will not only shape the future of cellular-based location services but also the future of the applicant. Through the vast network of the supervisor, the applicant will interact with world-leading academics and ind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Land-Atmosphere Interactions in China (LAIC)' under Seventh Framework.

assistant: **Concept**

The land surface as part of the Earth system affects the regional and global climate, and the climate in turn has an effect on the structure of the land surface. Increasing greenhouse gas concentrations, changing aerosol composition and load as well as land surface changes are influencing the climate of the Earth, globally as well as regionally. China and the Asia monsoon area have been identified as one of the critical areas of the Earth where environmental changes can have a profound effect on the whole Earth system.   The main objective of Land-Atmosphere Interactions in China (LAIC) joint research programme is to increase mobility and exchange of researchers between EU countries and China to obtain better understanding of land-atmosphere interactions for climate change research and environmental policy in China. This program focuses on four areas: 1) megacities, atmospheric composition and air quality, including aerosol particles; 2) drylands and the hydrological cycle; 3) process modelling and regional climate modelling 4) carbon cycle and trace gas flux measurements, including research and knowledge transfer at comprehensive flux measurement sites.   LAIC programme builds a basis for long-term collaboration between EU and Chinese research organizations in the area of climate change and air quality research. LAIC will exploit complementary expertise of the participant organizations and participants in order to create synergies among participants and to establish long-lasting partnership between European and Chinese research organizations. LAIC programme will utilize the state-of-the-art knowledge of the leading European and Chinese climate change and air quality researchers to achieve new scientific results and breakthroughs. As multi- and cross-disciplinary studie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Developmentally programmed pediatric sarcomas: a versatile platform for drug discovery and molecular precision medicine' (SARCOMAkids).

assistant: **Innovation**

Pediatric sarcomas account for ~20% of childhood cancers. They have disappointing survival rates, with very little therapeutic progress over the last three decades. We clearly have to rethink the science and find new ways to tackle these devastating tumors. I propose that new cellular models are needed that account for the developmental origins of pediatric sarcoma, in order to accelerate drug discovery and molecular precision medicine.Focusing on Ewing sarcoma, which is a developmental cancer caused by a (known) fusion oncogene expressed in (unknown) cells-of-origin, we will pursue a “build it to understand it” approach and construct in vitro and in vivo tumor models starting from human pluripotent stem cells (hPSCs). We will validate these models against our single-cell and spatial maps of Ewing sarcoma tumors, and we will pursue initial applications in academic drug discovery – targeting the regulatory programs of Ewing sarcoma cells, metabolic dependencies of the tumor microenvironment and developmentally programmed tumors in their in vivo context.To build Ewing sarcoma models in a molecular defined manner, we will map oncogene-competent cell states by inducing EWS-FLI1 expression in hPSC-based models of human development (Aim 1). We will create supportive tumor microenvironments by 3D differentiation and CRISPR screening in stromal cells (Aim 2). Finally, we will evaluate the ability of in vitro models to form tumors in mice, and we will pursue full in vivo modeling of Ewing sarcoma using genetically engineered teratomas (Aim 3). Compared to patient-derived xenografts, organoids or cell lines, our approach captures early events of tumorigenesis, providing complementary in vitro and in vivo models of Ewing sarcoma for biomedical and translational research. This appr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Comprehensive solutions of healthcare improvement based on the global Registry of Stroke Care Quality' (2021-2027).

assistant: **Concept**

RES-Q+ will build on the success of RES-Q (REgistry of Stroke Care Quality) - currently, used by many EU countries and 74 worldwide - to improve stroke care quality by collecting and analyzing hospital discharge reports. RES-Q+ will revolutionize these improvements by capturing the whole patient pathway. The solution will combine NLP with a clinically-validated semantic model to automate ingestion of hospital discharge reports in different languages and assist with audit and feedback. This will include creating a standard model for such reports and using AI to impute missing data. Further augmentations include the creation of two novel AI voice assistants, one to help patients provide feedback on their health and the other to help physicians provide high quality care.We will integrate all these tools into RES-Q+. This will be the basis for a European Open Stroke Data Platform, an open research platform for data aggregation, semantic harmonization and interoperability across European countries to promote the use and re-use of health data. We will facilitate efforts to define a standard European Stroke Hospital Discharge Report Exchange Format as a tool for better secondary use of data and healthcare in general. Consortium legal partners will develop a comprehensive legal and ethical toolbox as guidance towards legal compliance. This will boost wider adoption of such novel AI-based solutions by integrating all current and proposed Union legislation. Our clinical partners will provide medical records and steer the development to maximize clinical utility and validate final solutions. RES-Q+ will be deployed globally to solidify our position as European and global leader in quality improvement.  Eventually we will guarantee citizens a similar level of quality control during
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'INnovative TRiggEr techniques for beyond the standard model PhysIcs Discovery at the LHC'.

assistant: **Innovation**

The discovery of the Higgs boson at the Large Hadron Collider (LHC) closes a central chapter of the standard model (SM) of particle physics while raising several questions, such as the nature of dark matter, an explanation to neutrino masses, or the origin of baryon asymmetry in the Universe. The answer to those questions could be linked to the production of beyond the SM (BSM) particles which may have long lifetimes, compared to SM particles at the weak scale. If these long-lived particles (LLPs) were to be produced at the LHC, they would yield non-standard signatures which require dedicated identification algorithms. A complex filtering (trigger) system running sophisticated algorithms allows to decide, in real time, whether a given event of interest should be saved for data analysis or discarded. The general goal of this proposal is to enhance the trigger capabilities to enable the discovery of LLPs and thus find evidence of BSM physics exploring innovative technologies that may be of use in future facilities. With several years before the start of the High-Luminosity LHC (HL-LHC), it is now the perfect time to explore alternative trigger architectures and technologies not considered in the plans of the collaboration and that could not be explored otherwise. To this end, I will use a multidisciplinary approach involving advanced Machine Learning techniques and top-of-the-line ultra-fast processing platforms to propose an innovative solution that will improve the capabilities of future trigger systems. The foreseen studies might be the only way in which LLPs can be discovered at the HL-LHC. Any manifestation of such particles will revolutionise the field of High Energy Physics and help to answer several fundamental questions regarding the energy scale and nature of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'SATGENO: Regenerative gene repair therapy for muscular dystrophies'.

assistant: **Innovation**

Muscular dystrophies (MDs) are a group of about 50 different monogenic disorders characterized by progressive, irreversible muscle wasting, leading to loss of autonomy and premature death. Patients rely on palliative care; the disease burden is immense. Current gene therapy approaches do not address the underlying genetic causes. The challenges to develop gene therapies for MDs include the genetic variability and the lack of a safe drug delivery methods to muscle.MyoPax is a clinic-ready company focused on restoring muscle function in patients with muscle diseases via targeted regenerative therapies. For genetic MDs we have developed the Satgeno platform: We aim to harness the body’s natural regenerative capabilities to sustainably deliver a gene repair therapy for the first time to muscle. Satgeno leverages our patented stem cell technology to manufacture highly regenerative muscle stem (“satellite”) cells called Primary Human Satellite cells-derived muscle stem cells (PHSats). PHSats rebuild muscle tissue and, very importantly, generate new muscle stem cells in their respective niche. This capability allows us to 1) correct MD-causing mutations ex vivo in PHSats using virus-free, mRNA-mediated, CRISPR-derived gene editing, 2) deliver gene-corrected healthy stem cells to functionally important muscles in MD patients, and 3) sustainably rebuild healthy muscle function.With EIC support, we will conduct the first-in-human DELI550 trial, focusing on a frequent founder mutation. Pending safety and efficacy validation, we expand our approach into a comprehensive platform to treat various MD mutations affecting 400K+ people in the EU and US. This trial will mark a breakthrough. The platform has the potential to transform the patient´s treatment as acknowledged by Nature medic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Compact binaries as strong gravitational wave sources and progenitors of type Ia supernovae' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The accelerated expansion of the universe was one of the most striking discoveries in the 20th century and was only possible by using type Ia supernovae (SN Iae). Only the thermonuclear explosion of a white dwarf (WD) following the interaction in a binary system can explain the observed features. Several different binary scenarios are discussed including the merger and subsequent explosion of an ultracompact double white dwarf (double degenerate) or an explosion triggered by helium accretion from a helium star donor (double detonation).  The Laser Interferometer Space Antenna (LISA) is a space-based gravitational wave (GW) detector, which is currently being built by ESA. LISA will be sensitive to measure GWs directly of thousands of Galactic binaries, allowing for multi-messenger studies.   The PI proposes to conduct a detailed observational study to identify and classify at least a few hundred SN Ia progenitors and LISA GW sources to  1) derive compact binary space densities and predict rates for different SN Ia formation channels to solve the supernova Ia progenitor problem  2) provide the first observationally derived population of resolvable LISA sources and Galactic LISA foreground sources  To achieve this ambitious project the PI will use ongoing and upcoming sky surveys such as ZTF, BlackGEM, Gaia, Vera Rubin Observatory and SDSS-V combined with large-scale multiwavelength surveys. The large number of sky surveys combined with recent developments in data processing, including dense Galactic Plane regions makes this project very timely. The results will calibrate theoretical models for SN Ia, common envelope evolution and will help to find the optimal data analysis methods for LISA so that its mission requirements can be achieved.  The PI will successfully lead th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Glypican5-supported endocytic control of BMP4 signaling'.

assistant: **Innovation**

Increasingly, the glypicans, major membrane proteins that supply heparan sulfate at the surface of cells, emerge as essential for the reception and dissemination of morphogenetic signals. While the best recognized role of endocytosis in signaling is to down-regulate the signal by sending the receptor and/or the ligand to degradative compartments such as lysosomes, it has now become clear that endocytosis also contributes to activation of signalling. In this project, we propose to explore the importance of glypicans for mechanisms of endocytic/exocytic trafficking and fine-tuning of signalling. We suspect that, by associating with specific protein sorting and trafficking machineries, glypicans control the formation of distinctive ‘signalling endosomes’, involved in the transcytosis of HS-cargo and its recycling to the cell surface, influencing what signal-transduction machineries are activated, where they are activated, and for how long. This working hypothesis is explored, concentrating on the effect of Glypican-5 on Bmp-4 signaling, in vitro, by cellular and biochemical assays, tracing glypican and glypican-interacting proteins, and by functional interference, using siRNA, and in vivo, in zebra fish embryos, using the injection of anti-sense morpholinos and mRNAs. Using these combined and integrated approaches in test tubes, cells and model organisms, we expect identifying novel mechanisms of vesicular trafficking that are important for development, developmental disorders, and acquired disease. In general, this project proposed will support the career development of the researcher by enhancing her competence diversification through a complete training. This fellowship is an opportunity for the applicant to attain a leading independent position.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Vancomycin resistance regulation in the antibiotic-producers streptomycetes' (Vanrestrep).

assistant: **Concept**

Antimicrobial resistance is a critical health issue today. Important pathogens have become resistant to many or all available antibiotics and limited new antibiotics are in the pipeline. Vancomycin is used as a ‘last resort’ antibiotic treatment for many bacterial infections, but worryingly vancomycin resistance (VR) has spread to major hospital-acquired pathogens such as Enterococcus faecium and Staphylococcus aureus. Most pathogen VR gene clusters likely came from actinomycetes, the natural producers of glycopeptides and most other antibiotics of natural origin. Induction of VR in the model actinomycete Streptomyces coelicolor is highly influenced by nutritional conditions, in particular by the phosphate (Pi) concentration in the medium. My previous work has shown that VR in S. coelicolor is blocked with Pi concentrations above 0.2%; suggesting a key role of this nutrient in VR repression. Furthermore, I have isolated a mutant strain (SCO2594::aac(3)IV) lacking this Pi control over VR. This mutant has cell wall synthesis defects and up-regulates a putative small non-coding RNA (sRNA) located in the promoter region of the vanSR regulatory genes. This project aims to understand the mechanisms of Pi regulation of the S. coelicolor van cluster, and to expand this study to other nutrients that may also control VR. A main focus is on the role of sRNAs in the regulation, as they offer potential novel targets for future clinical exploitation such as “antisense RNA therapy”. The work also aims to understand the role of SCO2594 in VR and to identify new players involved in the process. The proposed project represents an excellent opportunity for the researcher to develop new skills whilst helping to ramp up the development of new antimicrobial platforms in the Salas lab.