RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'EX-DR TB: Elimination of Extensive Drug Resistance Through better Regimens for TB'.

assistant: **Objectives**

In 2022, the World Health Organization (WHO) recommended bedaquiline (BDQ)-based, all-oral regimens including pretomanid (Pa), linezolid (L), and moxifloxacin (M) (BPaLM), lasting 6-9 months However, BDQ-resistance is rising dramatically and threatening these advancements. Mozambique has reported BDQ resistance in 28% of MDR-TB isolates in 2024, up from 3% in 2016 and at 10% in South Africa (Ndjeka N, personal communication). Spread of BDQ-R TB must be slowed by antibiotic stewardship through more rapid, accurate, and near-patient diagnostics, and optimized management; until new treatment options with drugs that have no pre-existing resistance or are able to overcome small shifts in MIC will be available. The proposed EX-DR TB project includes diagnostic capacity strengthening, adapting treatment recommendations, and a trial of two new regimens composed of new drugs. The EDCTP EX-DR TB project will: 1.Develop treatment recommendations by a Delphi process with stakeholders - to make use of targeted next generation sequencing (tNGS) that is being rolled out by most national TB programmes - this will yield short-term benefit for patients and NTPs; and will slow the spread of BDQ-resistant bacteria;2.Rigorously evaluate two treatment regimens composed of new drugs, in a phase 3 clinical trial conducted to the highest regulatory standard – this will be the main focus of EX-DR TB. The trial objective will be to move a regimen towards regulatory approval by FDA and/or EMA, and WHO if supported by results. Thus, EX-DR will create the tools for containing the nascent epidemic of BDQ-R TB and make them available to healthcare providers and TB Programmes. EX-DR TB will be embedded in a larger coalition of funders and partners focused on implementing and evaluating diagnostics and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'NanOthermomteRs for THeranostics' (NORTH) targeting Horizon 2020.

assistant: **Abstract**

The goal of this project is to develop novel types of multifunctional nanoparticles combining temperature diagnostics and therapy. More specifically we aim at combining thermometry in the physiological range with either drug delivery or photodynamic therapy (PDT) all in a single hybrid nanoparticle constructed from Periodic Mesoporous Organosilica (PMO) with lanthanide inorganic nanoparticles grown inside the pores and/or voids of (hollow) PMO particles. For diagnostic purposes temperature measurements in biomedicine are of key importance, as temperature plays an essential role in biological systems. For biomedical applications measurements in the temperature range 20-50 ºC are essential (the so-called physiological range). Although detecting the temperature can be done employing robust, and already commercially available techniques, such as thermocouples or infrared imaging, optical temperature measurements at the nanoscale allow to reveal and study phenomena otherwise inaccessible to traditional thermometers such as measuring temperature of cells and even the organelles within them.  Theranostics is a recently emerging field of interest, which combines diagnostics with therapy. In this regard, the use of nanomaterials, which allow combining multiple functions in just a single particle, would be able to change the entire healthcare scene and the way certain diseases are treated. However, with the reported up to date nanothermometer materials there is very little room to expand towards multifunctional thermometric materials. We propose a rational design where hollow, porous, biocompatible, multifunctional materials would combine temperature sensing and drug delivery or PDT in a single particle, where the temperature measurements as well as drug delivery/PDT are all cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'LARGE EARTH OBSERVATION NEW SPACE ECOSYSTEM GROUND SEGMENT' (LEONSEGS), addressing dissemination and exploitation.

assistant: **Impact**

LEONSEGS is a federated environment (called Multi-mission Earth Observation Ground Segment Service Platform) of EO data providers that collaborate all together through harmonized interfaces and that are managed by a central automated multi-mission service, able to coordinate and produce for the End-User complex EO product. There are different types of EO data providers: EO products provider (like for instance existing EO constellation operators that offer their data and products) and EO satellite constellations (satellites that are managed by a Ground Segment as a Service –GsaaS- solution, and that allows not only access to data and products but tasking of future acquisitions).The proposed multi-mission ground segment shall federate New Space players supporting the heterogeneity of the New Space ecosystem through harmonized interfaces for each profile, and especially with:-New Space stakeholders which need or wish to externalize their ground segment infrastructures.-EO existing products providers with their own space and ground segment willing to access to the market that this infrastructure will offer.LEONSEGS is a multi-disciplinary fully complementary consortium. GMV has an extensive experience in coordinating international collaborative research projects and is the world-wide leader in ground segments. PLUS is a highly reputed academic partner with a cut-of-the-edge experience on EO processing. AISTECH is a New Space player in EO, operating a proprietary constellation. F6S is one of the best companies with expertise on community building, dissemination & communication, especially for engaging with stakeholders; F6S runs actually a world community platform with more than 4.5mil users and approximately 1.5 mil tech-startups.


**Keywords:** EO, New Space, flexible mul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Implementing wastewater and environmental surveillance for Mpox in Sub-Saharan Africa'.

assistant: **Concept**

Mpox, a re-emerging viral zoonotic disease, has recently posed significant public health challenges in sub-Saharan Africa, particularly in the Democratic Republic of Congo (DRC). The disease has led to thousands of suspected cases and hundreds of deaths, prompting the DRC Ministry of Health to declare a Public Health Emergency in April 2024. Given the rapid spread and high fatality rate of the outbreak, a coordinated research response is urgently needed to understand and mitigate this public health threat.Mpox's emergence as a significant public health threat in sub-Saharan Africa aligns with Project ODIN's core objective of addressing critical infectious pathogens through genomic surveillance and wastewater-based epidemiology. Building upon the successful foundation of Project ODIN, this proposal aims to implement a comprehensive water genomic surveillance system specifically targeting the Mpox outbreak in the DRC and neighboring countries.By leveraging advanced genomic surveillance and wastewater-based epidemiology, this initiative will provide novel, critical, and timely insights into the presence and spread of the Mpox virus in the environment. This information will guide targeted public health interventions, such as targeted vaccination campaigns and resource allocation to high-risk areas. Additionally, the approach will enable the early detection of the Mpox virus in water sources, allowing for rapid public health interventions to prevent further transmission.The project will identify Mpox virus sublineages with the highest impact on case numbers and fit them into a global context, providing evidence of international sublineages that likely emerged or spread early in the DRC and neighboring countries. This data will be crucial not only in addressing the immediate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'H3PS – High Power High Scalability Aircraft Hybrid Powertrain' (H3PS).

assistant: **Concept**

The H3PS starts in a completely new, challenging and probably never seen before revolution in General Aviation (GA). The main driver behind the H3PS project is to develop a new, greener propulsion system (a parallel hybrid powertrain) to pioneer one of the aviation industry’s solutions in reducing the environmental impact of air travel. The propulsion system to be designed and developed within the project will be suitable for powering four-seat GA aircraft, a market segment which employs today piston-powered engines, where the leading engine manufacturers are providing components whose basic technology, although constantly updated and reliable, is now over 50 years old and, in most cases, still needs leaded fuels to operate.The objective of the project is to put the basis for the development, manufacturing and in-flight test of a parallel hybrid powertrain for General Aviation by the involvement of three European GA market leaders: an aircraft manufacturer (TECNAM), an aircraft engines manufacturer (ROTAX) and an electric motors manufacturer (Rolls-Royce). The H3PS project objective is to fly a GA aircraft with the parallel hybrid powertrain demonstrating the challenging advantages of the configuration but also its high scalability level. “Breakthrough” concept will be achieved by demonstrating the feasibility of a power scalability for up to 11 seats airplanes.The main impact of the project will be related to the introduction of a really marketable solution to bring GA in the hybrid vehicles arena. Hybrid solution is today the most realistic intermediate way to step from gasoline operated powerplants to full electric systems offering the same performances, comparable initial acquisition costs and weights but featuring a more-than-acceptable cost saving in operations. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Hot Core around Low Mass Protostars'.

assistant: **Innovation**

Recent observations show the presence of a warm and chemically rich gas toward the low mass protester IRAS 16293-2422. This first detection has confirmed the presence of a Hot Core region around this object, characterized by chemistry abundant in reiterated species and in complex O and N-bearing molecules. For decades, Hot Cores were only attributed to massive protesters; warm enough to evaporate the mantles of the grains, and to enrich chemically their environment. The discovery of a Hot Core around a low mass protester gives rise to many questions regarding the processes responsible for such a particular chemical composition. These objects represent another challenge to understand the roles of gas phase and grain surface chemistry in the deputation process and in the creation of complex species. The detection of a Hot Core toward a Sun-like star shows that our solar system went through a similar chemically rich phase billions of years ago, as suggested the presence of amino acids in meteorites and comets. Therefore, low mass Hot Cores represent a perfect laboratory to reconstruct the past of our Solar System and to probe the beginning of life on Earth. This research project proposes a theoretical and observational study of low mass Hot Cores. A model developed by P. Camellia et al. (1993), which describes high mass Hot Cores chemistry, will be adapted to the astrophysical and chemical conditions of low mass Hot Cores. This model will be implemented with deputation processes and with chemical reactions that lead to the observed complex chemistry. Several observations are already planned to investigate other low mass Hot Cores and to assess their chemistry. Our model, constrained by our observational results, will give some predictions for further observations and allow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Operationalising Psychosocial Support in Crisis'.

assistant: **Concept**

Complex emergencies such as earthquakes, flooding, bombings, and the recent massacre in Utøya (Norway) can seriously affect entire populations and rip nations apart, with long-term psychosocial consequences impacting the most vulnerable as well as the helpers for years following the disaster.A large number of high quality European guidelines and tools for psychosocial support interventions in crisis management already exist and have been developed during the last two decades. OPSIC will build on this work by identifying gaps and assessing best practices and develop a new innovative comprehensive operational guidance system (OGS), which will serve as the operational interface between the existing guidelines and the practical intervention tools and methods. This interface is currently missing and hinders the effective operationalization of and compliance with the guidelines in practice.Based on new research and analysis of PSS guidelines, best practices and the long-term psychosocial impact of crisis, OPSIC will design and develop an web based comprehensive operational guidance system that will operate as a common shared platform and single point of reference for PSS in crisis management. The OGS will be validated through simulations tests in three countries with crisis managers, first responders, volunteers and possible victims and evaluated according to selected key performance indicators. Subsequently, the OGS will be demonstrated for a governmental end-user and a road map for implementation of the OGS into the end-user protocols will be prepared.For the development of the guidance system, OPSIC will focus on all four phases of crisis management; prevention, preparedness, response and recovery, and relate these to the following target groups; - crisis managers, interve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Lattice-QCD with Dynamical Overlap Fermions on Tera-Scale Cluster Computers' (2002-2006).

assistant: **Concept**

Lattice quantum Homodynamic (LQCD) is an established technique to determine theoretical non-preservative properties of the strong interaction between elementary particles. Advancements in LQCD are of vital importance in understanding standard model and beyond the standard model particle physics. Lattice calculations including dynamical fermions performed so far suffer from large systematic errors that arise from violation of choral symmetry or flavour symmetry. We propose to carry out the first pilot simulations in full QCD with choral fermions, with the goal to simulate significantly lighter quark masses than have been reached so far. The specific objectives of this proposal are:1) The generation of vacuum configurations using unquenched choral fermions.2) The calculations of various observable such as the topological susceptibility, choral condensate, and light meson masses.3) To work with numerical analysts at Supernal and Utrecht to increase the efficiency of the algorithms used in the computation.4) To develop efficient code for cluster computers, optimising the implementation of the hybrid Monte Carlo algorithm and fostering COTS cluster technology. This calculation will use the unprecedented processing power of the planned Tear-Scale Alice next computer, which will be installed by the end of 2003. We will work in close collaboration with computer scientists at Supernal and Karlsruhe to optimise the hardware and software of Alice next. This computer will be powerful enough to apply the hybrid Monte-Carlo algorithm to choral overlap fermions on moderate lattice sizes. After generating the vacuum configurations, we will calculate the observable by established methods. The training in advanced lattice theory on clusters, which is genuinely multi-disciplinary, aims to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'An easy-to-use garment for the non-invasive recording of the electrical activity of the human spinal cord' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Lesions of the spinal cord in humans are devastating and often lead to severe refractory forms of chronic pain. Also, enhanced sensitivity of spinal cord neurons – an abnormal condition called central sensitization – is crucial for the development and maintenance of chronic pain. Effective treatment of pain will depend critically on a better understanding of the electrophysiological changes that occur at spinal cord level. Still, the electrical activity of spinal cord neurons can be assessed only indirectly, unless invasive approaches are used. Due to serious anatomical and physiological hurdles, the availability of a non-invasive approach to measure the electrical activity of human spinal neurons (electrospinogram, ESG) is lacking. This is the problem that SpinRec aims to solve. The product resulting from SpinRec, compatible with simultaneous measures of brain activity (e.g. electroencephalography), will allow for the first time to directly explore spinal sensorimotor circuits in health and disease, and thereby allow cost efficient early diagnosis and stratification of patients with chronic pain and spinal cord injury.


**Keywords:** spinal cord, chronic pain, spinal cord injury, sensorimotor system, human, electrophysiology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Understanding Nanoparticle Transport Mechanisms in the Melanoma Microenvironment via a Tumor-on-a-Chip Approach' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The MATRIx aims to develop a 3D melanoma tumor model on a chip (ToC) using patient-derived xenograft technology, which mimics the natural tumor microenvironment (TME) to enhance nanoparticle (NP) delivery to the tumor site and enable personalized treatment.In Western countries, melanoma is considered one of the most widespread cancers. Due to its aggressive nature and resistance to drugs, melanoma is the subject of extensive research aimed at creating more effective medications. The clinical translation of nanomedicine for cancer therapy has been hindered by a lack of knowledge regarding the TME, mechanisms of NP uptake and transfer, technical limitations for model implementation, and individual variations in phenotype. ToC modeling is an indispensable tool in cancer research providing a 3D dynamic environment with regulated fluid flow and shear stress, co-culturing, vascularization, easy operation and readout method, and time and cost saving in contrast to other cancer models. in addition, ToC provides high-throughput screening of nanomedicines, susceptibility, and resistance of cancer cells against drugs, allowing personalized therapy for patients with low cost and high reproducibility.Development of NPs based on patient’s melanoma TME response to active targeting NPs is the focus of MATRIx which will be implemented for the first time. My project's key deliverables will consist of identifying key players of TME around NP extravasation and enhancing NP retention at the tumor site. This initiative will aid in the development of more effective personalized cancer treatment strategies and will be of considerable interest to both academic and industrial sectors. MATRIx also fills my knowledge gaps. Following MATRIX conclusion, I will establish myself as a leader in the fie