RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Age related changes in strigolactone control of adventitious root initiation' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Strigolactones are a newly identified (2008) group of plant hormones known to control bud outgrowth. Recently the applicant has discovered that strigolactones also inhibit the formation of roots from non-root tissues (adventitious roots), defining a new role for strigolactones in plants.   Adventitious root formation is central for clonal propagation of elite plants and requires the dedifferentiation of stem tissues followed by controlled cell divisions. Plant hormones including auxin regulate adventitious root formation and physiological properties such as age of the explants also determine root induction success. However, the interaction between ageing and plant hormones is poorly understood.  Preliminary evidence for age-related variation in strigolactone control of adventitious root formation suggests that the physiological conditions restricting adventitious rooting are likely mediated through a strigolactone signalling mechanism.  This project will characterize age-related variation in the strigolactone control of adventitious rooting. Explants from different developmental stages of Poplar and strigolactone mutants of Pea and Arabidopsis will be examined for adventitious rooting phenotypes and response to strigolactone. The project will also investigate interactions with the rooting promoter auxin particularly in relation to the newly identified ARF6, ARF8 and ARF17 regulatory pathway for adventitious rooting developed by Prof. Bellini.   This project will facilitate exchange of expertise between the strigolactone lab of Assoc. Prof. Beveridge (Australia), the auxin regulation of adventitious roots (Prof. Bellini, Sweden), the lateral root lab of Prof. Beeckman (Belgium) and the host lab of Prof. Geelen (Belgium) focusing on adventitious rooting and tissue culture
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Establishing of Cancer Mission Hubs: Networks and Synergies' in the context of a Horizon Europe call.

assistant: **Objectives**

Cancer- healthcare, research and innovation face core common challenges, such as fragmentation of initiatives and distancing from important stakeholders, requiring coordinated solutions. These challenges are recognized in Horizon Europe’s Cancer Mission Implementation Plan and in Europe’s Beating Cancer Plan. The proposal Establishing of Cancer Mission Hubs: Networks and Synergies (ECHoS) represents a unique opportunity to coordinate R&I and Healthcare actions on cancer with policy-making processes creating transnational communication & collaboration networks aligned with Cancer Mission objectives. Experiences shows that the setup and implementation of innovative health solutions are more likely to be successful when a broad range of stakeholders and decision-makers from the public and private sectors are part of the process. By fostering the creation of National Cancer Mission Hubs (NCMHs) in member states and associated countries ECHoS will create the conditions for organized stakeholders and individual citizens to collaborate and engage in policy dialogues. The implementation of the Cancer Mission objectives will promote more resilient and people-centric healthcare and research systems.ECHoS will produce (i) general models and guidelines for the creation of sustainable NCMHs, (ii) a knowledge exchange programme to support development of NCMHs competences, (iii) impact models and training sets to help efficiently engaging with distinct stakeholders, (iv) a toolkit for synergies to help NCMH engaging in collaborative work with individual European Initiatives, (v) a business continuity model envisaging long-term sustainability of a EU network of NCMHs and (vi) a calendar of events to create awareness on NCMHs and to help closing the gap in citizens’ participation in can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Antileishmanial and antitrypanosomal activities of alkyllysophospho lipids' to be submitted under Fourth Framework.

assistant: **Abstract**

* To determine the mechanisms of action of alkyllysophospholipids (ALPs) against Leishmania and Trypanosoma cruzi , including effects on the host immune response* To identify novel biochemical and molecular targets in Leishmania and Trypanosoma* To establish ALP resistant clones and identify mechanisms of resistance* To define interspecies and interstrain variation in sensitivity to ALPs* To define a structure-activity relationship of the antileishmanial and antitrypanosomal activities of ALPs as they represent a new selective model for further antiprotozoal drug development* To define rational drug combinations to be used in treatment.Expected Outcome* An understanding of the mechanisms of activity of a novel group of antiprotozoal drugs and the identification of novel drug targets* Data on drug activities and drug combinations useful for clinical studies on leishmaniasis and trypanosomiasis * PhD students will be trained in laboratories in Europe and South America and international links cemented.* Results will be published in international journals, presented at international meetings and be the central focus of an EC meeting to which representatives of pharmaceutical companies will be invited.* The activities of ALPs, alone and in combination with other drugs, will be determined against both exacellular and intracellular forms of different strains/species of Leishmania and Trypanosoma by microscopical and biochemical techniques.* The effects of ALPs on membrane pathways, in particular sterol, lipid and glycosyl-phosphatidylinositol (GPI) anchor biosynthesis, will be studied.* Effects on parasite differentiation and signal transduction will be examined in particular in relation to roles of protein kinases, phospholipases, calcium levels and adenylate cyclase.* The up
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Groundbreaking biocontrol solutions for a resilient agriculture' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Pertinent is developing products that combine the effectiveness of chemical pesticides with the safety of biocontrol products.Pertinent is applying to a blended funding program combining €2.5M of grants and €6M in direct investment to cover commercialization of its first products and its accelerated growth journey in the crop protection market. The funding coming from the EIC Accelerator Challenge 2023: Novel technologies for resilient agriculture will be critical to help Pertinent accomplish the following steps: conduct the final studies to lock the product formulation for EU and the US; register the active substance and get market authorisations; build a commercialization organization in the EU and US; successfully launch the selected products in the targeted crops for EU, USA and Brazil and Mexico; build production capabilities in France to supply the growing demand (€10M in CapEx); build a R&D lab to formulate the new products, test them and conduct analytical studies (€2M in CapEx).The main milestones of the project are:•2024: Launch of first crop protection biocontrol products in California (grape vines and berries);•2025: Temporary market authorisation in Eu for sugar beets and grape vines; first launch in Mexico;•2028: Launch in Europe under full market authorisation. Pertinent has already established a network of partners in Europe and in the USA that will support its business efforts and have written letters of support in R&D (Universities, testing labs), manufacturing (suppliers and contract manufacturers), field testing and validation (Technical institutes) and commercialization (Distribution agreement already signed for Europe with De Sangosse). Prominent investors have also expressed in written LOI their strong interest in participating in the next round o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Leveraging on new knowledge and latest advances in science & technology to allow large communities of EU textile machinery SMEs to innovate their products & keep EU leadership in added value textiles'.

assistant: **Objectives**

Although Europe keeps the world-wide leadership in the textile market, Far East has become a major manufacturing area. This situation opened new perspectives in fast growing markets for the European manufacturers of textile machines, 95% of which are SMEs. However, as today textile machines mainly consist of established electro-mechanical systems the advantages were only of short duration. An intensive effort of the manufacturers of textile machines in Asian countries in introducing the production of cheaper textile machines comparable in output but incomparable in price has started. As a result, Far-East has become the first applicant in the world as far as the number of patents on new machines and equipment for textile manufacturing is concerned, almost filling the gap with Europe. This represents a major threat for European textile machinery SMEs, their competitiveness and knowledge base. To address this challenge in 2006 MANUTEX has been jointly launched by the European Technology Platform for Manufacturing (Manufuture) and the European Textile Technology Platform in order to realise closer collaboration in pre-competitive research and development at European level between the Textile and related Machinery Industries. In such a scenario, the NU-WAVE project represents an ambitious R&D programme between the European Textile Association EURATEX and VDMA/ACIMIT as National SME AGs representing 60% of textile machine manufacturing in EU-27, grouping the main stakeholders in the above mentioned MANUTEX initiative and key RTD players in the relevant knowledge areas. Advanced web-services provided by SME AGs will result from the project to support in the design of a new generation of flexible and high-performance machines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Health-promotion through obesity prevention across Europe (hope): an integrated analysis to support European health policy' (HOPE) targeting Sixth Framework.

assistant: **Abstract**

The prevalence of obesity in Europe has been increasing, with rates doubling during recent decades in several countries. An increasing number of Member States has obesity levels (BMI>30) exceeding 20% in the adult population, and more than 50% of adults is overweight (BMI>25). The number of overweight children is estimated to be 22 million in 2006. Insight into the underlying determinants of obesogenic behaviours in Europe is limited, and information about effective obesity prevention interventions and policies is scattered.This project aims at supporting and advancing the development and implementation of systematic, evidence-based European, national and regional policies effective for the prevention of obesity and its negative consequences on health and health inequalities. The project provides information and inventories of obesogenic nutrition and physical activity behaviours, important environmental determinants of these behaviours, effective intervention approaches across Member States, and of the potential impact of interventions and policies directed at key determinants of obesity in the European Union.Specifically, the project aims to:- Create a European scientific network on environmental determinants and interventions of nutrition, physical activity, overweight and obesity prevention, which will put together all expertise and projects that are currently ongoing or being developed in the area of nutrition, physical activity, overweight and obesity, and of socio-economic inequalities in these issues within the European Union.- To carry out quantitative analyses, modelling and systematic reviews on obesogenic physical activity and nutrition behaviours, their environmental determinants, consequences on health and health inequalities among children and adults, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A Sustainable Soil Solution: Scaling up Novihum, an innovation to convert bad soil into better, make brown coal clean and barren land green, and profitably advance food security in Europe and beyond' in the context of a Horizon 2020 call.

assistant: **Objectives**

Soil is a vital – though often neglected – tool for increasing the resilience and security of food production, as recognized by the UN’s declaration of 2015 as the International Year of Soils; improving it can reduce erosion and enhance drought tolerance, crop yields, water and nutrient efficiency, and long-term land fertility.Novihum is a uniquely scalable innovative soil conditioning technology that replaces natural humus in degraded and arid soils, significantly increasing crop yields while reducing water use and pollution. It is produced by enriching abundant lignite (brown coal) in a highly efficient industrial process, and is affordable, easy to use, long-lasting (>10 years), and good for the environment. Its unique set of properties make it novel to the market and highly competitive with all other soil conditioners, which are typically difficult to use, transport, or scale up. Novihum Technologies GmbH was founded in 2012 to commercialize the patented technology, and has attracted venture capital investment from the EU and US.The objective of the Project is to scale up the Novihum production technology from prototype to a Pilot Facility in Germany, where an industrial production line suitable for scaling up to profitable commercial scale can be tested and refined. It will also demonstrate Novihum’s high-value impacts to potential customers and expand the product line. It will result in the know-how and proof of performance necessary to scale up to commercial production, and a sophisticated global customer and partner network that will facilitate successful market entry.The commercial potential for Novihum is very large – as are its impacts on the security and resilience of food production and on the environment – with more than 3.5 million sq km of land in need o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Tailored implementation for chronic diseases' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Project aim. Chronic diseases represent an important challenge facing healthcare systems. Research has consistently shown gaps between knowledge and practice for chronic illness care. Tailoring implementation interventions implies that the choice and content of implementation interventions are based on assessment of local barriers and enabling factors. It is widely believed that tailoring contributes to effective implementation, but little is known about specific methods and models for tailoring. The project ‘Tailoring implementation for chronic diseases’ (TICD) aims to develop better methods of tailoring implementation interventions to barriers and enablers for knowledge implementation in chronic illness care.Project plan. The 48-month project has been organized in 4 research work packages, a dissemination work package and a project management work package. WP1 will systematically review evidence on methods and models for tailoring implementation interventions. WP2 will test different methods and models for identifying barriers and enablers for implementation. WP3 will test different methods and models for matching implementation interventions to barriers and enablers. WP4 comprises of evaluations of the effectiveness of the resulting implementation interventions, and the influence of hypothesized barriers and enablers. We will perform comparitve evaluations, focusing on five chronic conditions: chronic heart failure, obesity, mental health, asthma and COPD, and multimorbidity.Deliverables of the TICD project are: scientific papers on the validity and effectiveness of specific tailoring methods and models, practical guidelines on tailoring for stakeholders, and specific evidence on improving medical care for the targeted chronic conditions..The TICD consortium comprise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The cytoskeleton and Cadherin-2 are tightly linked to coordinate nucleokinesis in migrating neurons'.

assistant: **Objectives**

The cerebellum coordinates the body’s movements. It consists of distinct layers of neuronal populations, but during embryonic development, these neurons are generated distantly from their final locations. In zebrafish, this means that cerebellar neurons have to migrate from the upper rhombic lip to the midbrain-hindbrain boundary and further. While descriptions of the migratory pathways for the different neuronal populations have become available in recent years, fundamental questions of this process are still unanswered. Firstly, we currently do not know how guidance of these cells is achieved and translated into directional motility. Activity could be a guiding cue, as it creates intracellular Ca2+-transients which determine directionality in cerebellar neurons. Similarly, depletion of Cadherin-2, a cell-adhesion molecule and key regulator of cell migration, leads to loss of directionality. If activity works through Cadherin-2 to guide cells, it would present a novel way of transmitting information from outside to the inside of cells. We will test this notion using the latest genetic tools. Secondly, Cadherin-2 influences centrosome-positioning, yet we do not know the molecular mechanism of this. IQGAP1 could be the link between Caherin-2 and the microtubules, but this remains to be proven. Thirdly, in order to generate movement of the cells, the forces from the cytoskeleton need to be transmitted to the nucleus. Two models for such mechanisms are being debated, and we will test both in migrating cells in vivo. To address these questions, we will use an interdisciplinary approach combining techniques and knowledge from cell biology, developmental biology and genetics with advanced in vivo time-lapse imaging.Understanding how the cells’ migration is guided and regulate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Epigenetic silencing of transposable elements in Lake Malawi cichlids' in the context of a Horizon 2020 call.

assistant: **Objectives**

Proper regulation of transposable elements (TEs) by Piwi-interacting RNAs (piRNAs) is critical for fertility and embryogenesis in animals. Because TEs need to evade silencing to replicate, they are engaged in an evolutionary arms race-type of genetic conflict with their host. These arms races between TEs and the piRNA pathway result in rapid evolution of piRNAs and piRNA regulatory factors, which in turn leads to genetic incompatibilities observable in interspecific hybrids that are relevant to speciation. New evidence supports the fast evolution of piRNA pathway factors in the cichlid radiation of Lake Malawi, where 800-1000 different species have evolved in only 800,000 years. The main objective of TSILENCICH is to understand how TEs and piRNAs co-evolved in these animals, throughout their explosive diversification.I have recently identified an expansion of piRNA pathway factors in Lake Malawi cichlids. While these factors are enriched in the germline in most metazoan species, in cichlids these genes exhibit remarkably higher expression in the brain, suggesting novel functions. I will construct new tools to test if piRNAs regulate the expression of TEs in the cichlid brain, and what role this regulation might play in brain development.In addition, I will test the hypothesis that TE epigenetic silencing is compromised in cichlid interspecific hybrids, utilizing A. calliptera and Tropheops sp. mauve, two cichlids with distinct eco-morphological and behavioural characteristics, and their hybrids. I will profile the epigenetic landscape in the parental species, as well as in fertile F1 and F2 hybrids, to investigate if TE expression becomes progressively more imbalanced across generations. The proposed work will shed light on the origin of piRNA pathway/TE conflicts and o