RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Function of centromeres during meiotic bouquet stage and protein composition of telomeres' to be submitted under Seventh Framework.

assistant: **Abstract**

Meiosis is a fundamental process in cell biology. During meiosis several unique features events occur such as segregation of homologs rather than sister chromatids and repair of double strand breaks by recombination of the homologs happen. During the first reductional meiotic division, the telomeres cluster in a formation called bouquet". The bouquet is important for the establishment and maturation of the spindle during meiosis, and is conserved in evolution. Initial results lead us to suspect that the bouquet might affect chromosome segregation through effect on meiotic centromeres. In my this project I intend to study the effect of bouquet disruption on the protein composition and microtubules attachment of centromeres during S. pombe meiosis. I plan to investigate the possibility that a cis effect is mediated between the telomeres and the centromere of the same chromosome. This study will be conductedwill be accomplished by live cell imaging using fluorescent microscopy, together with advanced genetic techniques available in fission yeast. In addition, I intend to isolate all the proteins associated with a pombe telomere. This will be accomplished by using the newly developed PICh technique, and by careful quantification of the yield and use of a unique control without telomeres available only in fission yeast."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Infinity in Mathematics: A Philosophical analysis of Critical Views of Infinity'.

assistant: **Innovation**

This project’s research goal is a systematic philosophical and mathematical analysis of critical views of infinity: views which have questioned one or more aspects of standard approaches to infinity in mathematics. Criticism of infinity originates in fundamental debates at the turn of the 20th century and re-emerges in contemporary mathematics under the stimulus of computer applications. The project’s first aim is to develop a novel rigorous examination of what is objected to infinity and why. The next goal is a philosophical and mathematical analysis of this criticism and of strategies proposed to overcome the perceived problematic nature of the infinite.To achieve these goals, the ER will integrate precise philosophical inquiry with state of the art knowledge of contemporary mathematics. She will analyse the early 20th century texts and compare that criticism of infinity with the one which emerges in contemporary mathematics; she will use a range of logical tools to sharpen and analyse the fundamental concepts of this debate.  The ER has the ideal profile to initiate, with the support of the host institution, an interdisciplinary analysis of the mathematical infinite, as she is simultaneously a mathematician and a philosopher, with years-long experience in logic. The Department of Philosophy at the University of Oslo is the perfect research environment for carrying out this project: the supervisor, Professor Øystein Linnebo, is leading figure in EU’s philosophy of mathematics and this project is very well aligned with his group’s research interests. Through a programme of training through research, the ER will strengthen her philosophical readership, broaden her range of competences, forge new connections to the philosophical community and gain skills in dissemination
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Probing spin dynamics in the QGP via spin-dependent Λ–Λ observables'.

assistant: **Objectives**

Quantum Chromodynamics (QCD) is the theory of the strong interaction, yet its non-perturbative regime, where quarks and gluons bind into hadrons, remains incompletely understood. Heavy-ion collisions at the LHC create a strongly interacting medium, the quark–gluon plasma (QGP). The role of spin in this quantum fluid, and its relation to quantum correlations and spin-dependent forces, is still largely unexplored beyond single-particle polarization measurements. This project pioneers spin-dependent studies using Λ hyperons, whose parity-violating weak decay self-analyzes spin by its decay particle momentum. Two objectives are proposed: (1) measure Λ–Λ two-particle spin correlations to access singlet and triplet components via the relative angle of decay protons 〈cosΔθ〉) in the rest frame of Λs and to study spin dynamics of QGP (2) develop spin-dependent femtoscopy to separate spin channels in the Λ–Λ correlation function and extract spin-dependent scattering parameters and interaction potential. These observables probe whether hadronization preserves quark-spin correlations, whether initial-state spin fluctuations survive the QGP, and the spin structure of hyperon–hyperon forces, providing complementary constraints to lattice QCD and hypernuclear data. The analysis exploits ALICE Run-3 Pb–Pb data (over 20 billion events), improved vertex precision with detector upgrades, and ML-based selection to secure statistical power and control systematics (feed-down, acceptance, backgrounds). By establishing spin correlations as new QCD observables, the project integrates quantum information ideas into heavy-ion physics, delivers unprecedented constraints on baryon interactions, and trains a researcher at the interface of experiment, theory, and data science.


**Keywords:** Quark–g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mitochondria and beta-amyloid in brain ischemia/reperfusion' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

This project is to test whether beta-amyloid peptide accumulates in mitochondria during brain ischemia/reperfusion, whether it impairs mitochondrial functions and induces cell death in a mitochondrial permeability transition-dependent way, and whether estrogens and antioxidants can prevent these events. Accumulation of beta-amyloid peptide (Abeta is a key factor in Alzheimer's disease (AD). Increased levels of Abeta are observed in both ischemia/reperfusion- and AD-damaged brains, and ischemia often precedes AD.Mitochondria are the primary target of ischemia and subsequent reperfusion, and they are both the source and the target of reactive oxygen species (ROS) generated under hypoxic and reoxygenated conditions. Recent evidence indicates that Abeta accumulates intraneuronally and intramitochondrially. In mitochondria, Abeta is shown to inhibit cytochrome c oxidase, to change mitochondrial membrane properties, mitochondrial capacity to accumulate calcium, and to stimulate mitochondria-related apoptosis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantum superlattices for scalable SWIR photodetectors' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

QUASAR aims to demonstrate the feasibility of a new class of short-wave infrared (SWIR) photodetectors based on three-dimensional (3D) quantum dot superlattices, developed from foundational research carried out under the ERC Advanced Grant “Design and Engineering of Optoelectronic Metamaterials” (DEOM). Building on recent breakthroughs in solution-processed materials and large-area superlattice assembly, the project targets the fabrication of retina-safe SWIR detectors with high detectivity (≥1012 Jones) and fast modulation response (≥820 MHz), enabling application in advanced LiDAR systems and other high-performance sensing platforms.The 18-month work plan is structured around two parallel technical pathways: one focused on p–n photodiode architectures and the other on phototransistors offering current amplification. Both routes explore the integration of highly ordered PbS quantum dot superlattices with tunable electronic properties. The project also includes key activities in IP strategy, market analysis and business model exploration.Key potential target applications span automotive LiDAR (for 3D vision and obstacle detection), industrial automation (moisture and contaminant detection in manufacturing) and biomedical imaging (non-invasive diagnostics in the SWIR range). These sectors require improved performance-to-cost ratios, fast detection speeds, and scalable integration—gaps this technology is designed to address.The project will validate the technology under device-relevant conditions while building the strategic foundation for market uptake. The outcome will be a characterised proof-of-concept device, market entry strategy, and exploitation roadmap, supporting follow-on initiatives such as EIC Transition or industrial co-development.


**Keywords:** QDs, SWIR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Fragrance chemical allergy: a major environmental and consumer health problem in europe', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Sensitivity to fragrance ingredients is acknowledged as a common and clinically important problem in Europe. At least 1-2% of the general population is allergic (delayed hypersensitivity) to standard indicators of fragrance chemical allergy, which makes contact sensitisation to fragrances the most common cause of contact eczema, next to nickel. At the present time, there is no treatment, other than symptomatic, for fragrance hypersensitivity reactions and the only means available to improve public health in this sector is prevention. The proposed programme aims to increase the safety standard of fragrance compounds by improving primary and secondary prevention. Our objectives are to develop a new risk assessment strategy based on chemical analysis and Quantitative Structure Activity Relationships, to identify new fragrance sensitises, to improve diagnostic means and to assess environmental exposure. This will be achieved through a unique research structure associating university, governmental and industrial research centres, with a trans-European clinical network.The Fragrance Allergy project respected the whole milestones proposed for the research programme. The different tasks achieved by each workpackage are resumed below.WP1: A new method has been developed and validated for the identification of sensitizers in complex mixtures using the model of oak moss. The method is based on the combination of bioassay-guided chemical fractionation, gas chromatography-mass spectrometry analysis and structure-activity relationship studies. Atranol and chloroatranol have been identified as major sensitizers in oak moss absolute. A minor sensitizer, methyl-b-orcinol carboxylate, has also been identified.WP2: The oxidative degradation at air exposure of fragrance terpenes has been s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enzyme Microarrays-An integrated technology for the deconvolution of complex biochemical systems, drug discovery and diagnostics' under Sixth Framework.

assistant: **Concept**

The deciphering of the human genome laid the ground for a far more challenging task: the understanding of the intricate and diverse mode of action of the gene products, the proteins. The relative lack of appropriate technologies capable to deal with this c omplexity, makes the functional, molecular deconvolution of the proteome a still distant scientific goal of prime importance. Our research will develop and use novel enzyme microarray technologies (EMTs), a uniquely powerful tool for activity-based proteom ics. This technology relies, among other novelties, on the development of a variety of chemical probes that will monitor the activity of a multitude of microarrayed enzymes. We will use the enzyme microarray technology in our laboratory in conjunction with designed chemical libraries in order to perform a detailed, en masse, molecular understanding of the activity of important families of enzymes such as proteases, enzymes involved in phosphorylation/dephosphorylation, as well as of enzymes involved in the ubiquitination pathway. Large scale specificity correlations between the substrate specificity profiles of enzymes from these families will substantiate new hypothesis about the involvment of important enzymes in networks that govern many important biochem ical processes. The versatility and reliability of this technology can be used in two practically relevant formats: High-Throughput Screening and activity-based diagnostics. Our research is directly relevant to the Thematic Priority 1 of FP6 and will be ac hieved through the creation of a team involving the international mobility of the team members.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Vascular niche and tumor microenvironment' to be submitted under Seventh Framework.

assistant: **Abstract**

Cancer progression is a complex process where cells acquire aberrant proliferative, survival and migratory properties, as well as the ability to trigger the formation of a dedicated tumour blood supply. There is now compelling evidence that the bulk of the malignant cells in cancers contained a rare fraction of self-renewing, multi-potent, and tumour-initiating cells, termed stem-like cancer cells (SLCCs), that constitute a reservoir to generate and/or maintain the tumours. Such as developmental or normal stem cells, cancer stem cells reside within a stem cell niche, which heterogeneous composition always contains a vascular structure. Therefore, in addition to the delivery of nutrients and oxygen, and to provide a circulating option for metastatic cells, the tumour blood vessels may also form a specific and confined microenvironment where endothelial cells from the vascular wall and tumour stem cells from the tumour mass may interact. Indeed, these SLCCs reside in close proximity of tumour blood. In line with these recent observations and hypothesis, we propose to explore the nature of the interactions between “cancer” stem cells and brain endothelium, and how this niche may impact both stemness properties and endothelial barrier function. My research program involved 3 major aims:- Influence of the endothelium/cancer stem cell interactions on their transcriptome- Modulation of mTor signalling axis in the tumour vascular niche- Semaphorin signalling in the vascular nicheThrough the combination of innovative technologies and approaches, such as transcriptome analysis, cell imagery, in vivo model of angiogenesis, we have here a unique opportunity to better understand the basis for molecular and cellular interactions within the tumour microenvironment. Overall, I expect m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mapping Skills and Competencies; Providing Access to Knowledge, Tools and Platforms;  and Strengthening, Disseminating and Exploiting Success Outcomes for a Skilled Transatlantic eHealth Workforce' (EUUSEHEALTHWORK).

assistant: **Concept**

The EU-US eHealth Workforce Development Consortium has an overall goal of mapping, quantifying and projecting the need, supply and demand for workforce skills and competences, utilising these results to further develop IT skills and training programmes for the healthcare workforce. This work is a continuation and further development of the EU-US collaboration under the EU-US MoU eHealth Roadmap, leveraging the work this group has developed to date, including the HITCOMP Tool and Repository.  Additionally, we hope to build upon that work to include intersecting it with foundational education and training methods and materials in eHealth.  We will continue analysing the needs, trends and approaches to improve the health IT workforce. Finally, we will provide an interactive web platform in which end-users, educators, governments and industry can: communicate; exchange information; provide and locate opportunities for training, skills development and employment opportunities; and increase knowledge related to the eHealth, health information technology, and health informatics disciplines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The first ultra-thin, flexible and durable pseudocapacitor fully integrated in a device for low power applications'.

assistant: **Objectives**

There is growing interest in flexible and thin electronic devices for different applications such as wearable devices, healthcare, RFID, or smart surfaces among others. Conventional batteries that are available are bulky and rigid, thereby creating an urgent need for energy storages device with characteristics that match the device itself – thin and flexible. Thin-film batteries or supercapacitors are a first attempt at solving these issues, but these still fall short. We have developed DuraCap, the first pseudocapacitor which works in a wide temperature range (-50 to +180oC) and survives up to 250oC during the manufacturing process. DuraCap is flexible, transparent and 4 times thinner (~1µm) than current solutions. It can be applied in broad materials (polymers, ceramics) and is non-toxic and non-flammable. These unique features of DuraCap combined with its high power-density, high charge rate, flat discharge curve, and long lifetime (>10 years) and unlimited shelf time address the market need. Our final aim is to develop the world’s first commercial energy harvester, energy storage and power management in a single device for low power applications such as sensors (RFID, smart cards, IoT), wearable devices or medical patches. Successful trials of DuraCap with a TPMS sensor installed in a wheel has validated market suitability and technical feasibility of DuraCap. The support from end-users such as e-peas, a semiconductor manufacturer specializing in solutions for IoT, or LG Group who have experience in deployment of energy storage solutions, will help us to accelerate market launch and adoption of DuraCap. Within 5-years of its commercialization, we expect €24million of  cumulative profit to achieve an ROI of 7:1.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SLIC-Biosensors in molecular diagnostics: nanotechnology for the analysis of species-specific microbial transcripts' (SLIC), addressing dissemination and exploitation.

assistant: **Impact**

Molecular diagnostics of microbial pathogens is an integral part of modern medicine. The growing need for direct genotyping and/or the screening of the transcriptome calls for the development of alternative technologies. The STREP consortium plans to devel op a cost-effective platform for the identification bacterial species based on the SLIC-Nanobiosystem. Using tmRNA transcripts of the bacterial ssrA gene, we will be able to detect, quantify and identify bacterial species in a single homogenous assay forma t. The SLIC-Nanobiosystem consists of a self-assembled lipid bilayer membrane that integrates a synthetic ligand-gated ion channel (SLIC). The SLIC comprises a capture molecule that can specifically bind a given analyte, a process that is monitored via ele ctrical impedance spectroscopy. With this system the effect from even a few channels can be resolved thus providing an ultra-sensitive, highly stable and versatile biosensor platform. We intend to employ transcripts (tmRNA) of the ssrA gene in order to ide ntify bacterial species present in clinical samples. These transcripts occur in high abundance and contain a core sequence that is species specific, a feature which will be exploited to identify infectious disease pathogens. Identification of the different bacterial tmRNA transcripts will be accomplished by displaying a library of nucleic acid capture probes on the SLIC. This will enable species identification and discrimination between one or more species present in the sample if mixed species infection is present. Since the detection equipment will be based on electronics, the realization of miniaturized/compact and cost-effective instruments will be possible. Our approach will lay the foundation for a new generation of multiparametric molecular testing sy ste