RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Papiro Opened Workflow Engine & Resources' in the context of a Fifth Framework call.

assistant: **Objectives**

This projects aims at extending component-based development practices to all phases of the software life cycle of the Company and not only, as is common practice today, to the programming activity. The aim is thus that of ensuring causality and coherence between planning and development of software projects. The experiment will be applied to a business case concerning the evolution of a proprietary document management system, called Papiro Planet, towards a Workflow driven document management system. Expected benefit will be so the definition, validation and standardising of a complete component-based software development methodology.Work description:The aim of the project is the adoption and experimentation of best practices concerning Analysis and Design of Component based software systems and Wrapping techniques of pre-existent software tools/applications to be re-used as standard software components, in a well defined component based software architecture.The project will be deployed through three logical sequential phases:1. Experiment set up;2. Specification and prototyping of the domain architectural framework;3. Sw. Component provision and integration. Management, technical, measurement and dissemination activities will occur during each phase in the context of ad hoc work-packages defined for the project. The project activities will be deployed under the responsibility of the company proposer. The experiment will be done on top of a baseline project which has a strategic relevance for the Company: it concerns the evolution of a proprietary document management system, called Papiro Planet, towards a Workflow driven document management system.Milestones:M1: End of phase 1; Expected results: Know how on component based software engineering; Application guidelines
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Role of PSIP1 in prostate cancer development and drug resistance' under Horizon 2020.

assistant: **Concept**

Understanding the cancer-specific genetic alterations is fundamental to devising novel treatment modalities. This project aims at understanding the role of PSIP1, posterior homeotic domain-containing transcription factors (HOX TFs) and androgen receptor (AR) in transcriptional regulation of prostate cancer cells. These transcriptional regulators are integral to the normal cell homeostasis and are dysregulated in various cancers. Through the preliminary data and analysis, this proposal recognises an interlink between these three factors and the ability of this trio in mediating a cancer-specific transcriptional alteration through activation of cancer-promoting transcriptional enhancers. Using a powerful combination of genome editing, functional genomics and bioinformatics, this proposal aims to discover altered transcriptional programme and its impact on cancer progression and treatment resistance. This project combines the expertise of the researcher in cancer biology with the competences of the host in epigenetics and functional genomics. This project will impart the talented researcher with comprehensive research training in chromatin biology and functional cancer genomics at an elite research Institute, in order to increase his prospects to become an independent research leader. The researcher will also profit from postdoctoral training opportunities in transferable skills available at the host's institution. Completion of the research and training objectives will significantly shape the development of the researcher into an independent leader, assign him a firm place in the European research network


**Keywords:** Prostate cancer, PSIP1, HOX TFs, resistance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on '4D TOMOGRAPHIC AND AVO INVERSION OF SEISMIC LITHOLOGY FOR HYDROCARBON EXPLORATION AND PRODUCTION'.

assistant: **Concept**

For both hydrocarbon exploration and production, reservoirs have to be characterised accurately for the structure and lithologic properties of rocks : so we could estimate fluid movements in reservoirs to enhance production. Seismic tomography can be used to get accurate P wave velocities. Once the velocity model is obtained, 3D amplitude preserving pre-stack depth migration, followed by Amplitude Versus Offset inversion (AVO), will yield an accurate structural image coupled with lithologic and fluid attributes. By applying this technology to time lapse 3D marine surveys (4D), we can monitor fluid movements in a producing reservoir and estimate the porosity and the hydraulic connectivity : these are critical for both reserves evaluation and optimal location of a new production wells.Three-component receivers, as in Ocean Bottom Cable (OBC) surveys, allow to record and separate P and S waves. Comparing the elastic Earth Model obtained by OBC with that one from conventional marine surveys, we will decide the benefits from OBC surveys in 4D technology. We will compare also the costs of one versus multi-component seismograms in real cases.The experience by synthetic data proved that the proposed approach is adequate for the 4-D analysis, and that anisotropy effects cannot be neglected. Furthermore, a very high precision is necessary in seismic tomography for imaging the fine details sought.An integrated system for AVO and tomographic inversion will be a precious tool for both seismic exploration and hydrocarbon production. It will provide a robust and reliable depth model in 3D from seismic data. By estimating the Vp/Vs ratio, and using 3D amplitude preserving pre-stack depth migration and AVO inversion, we will better characterise the reservoir interior. Most of the planne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Associations, Wealth Creation, and Governance in the EU: The Governability of EU Business Associations' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Associations are central to some systems of economic management, but despite its greater reliance on outside input to policy making when compared to member states, not yet to the EU. EU wide business associations offer the prospect to support public policy making, and to implement policy initiatives aimed at stimulating wealth creation through the encouragement of global sectoral competitiveness, but certain characteristics of associations, their environment, and member incentives may account for differences in their governability and hence their ability to contribute to EU wealth creation.The purpose of this two part conference series is therefore to:1. exchange expertise and transfer knowledge between researchers and policy practitioners (see 'training' below);2. encourage the development of unconventional thinking and new approaches to understanding the limits and potential of business associations in the specific EU environment to contribute to public policy goals;3. encourage the development of unconventional thinking and new approaches to understanding the support needed from Eu institutions in order to develop the role of collective business actors in European governance;4. develop lasting support networks between the actors identified in 1. above.The first meeting will focus on perspectives, analysis and information on business associations and their operating environment, while the second meeting will focus on the support needed from EU institutions in order to develop the role of collective business actors in European governance. Whilst previous conferences have been aimed at general discussions of 'lobbying', none have specially addressed the crucial role and capacities of EU associations - the 'natural constituency' of the Commission.ftp://ftp.cordis.lu/pub/
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'SHOTPROS: A HUMAN FACTORS BASED (VR) TRAINING FRAMEWORK FOR DECISION-MAKING AND ACTING CAPABILITIES UNDER STRESS AND IN HIGH-RISK SITUATIONS FOR EUROPEAN LEAS'.

assistant: **Innovation**

The number of incidents where police officers are first responders in critical situations with severe threat circumstances has drastically increased. A major challenge for these first responding officers is to properly evaluate the situation and decide how to further proceed and to assess and choose the most appropriate strategy. The appropriateness of this decision is highly critical as it has a strong impact on the potential success of the operation as well as on the potential impacts, scene environment (e.g. witnesses, involved civilians, etc.) and consequences.So the SHOTPROS project aims to investigate the influence of psychological and contextual human factors (HFs) on the behaviour of decision-making and acting (DMA) of police officers under stress and in high-risk operational situations in order to design better training for police officers to improve DMA Performance. SHOTPROS will develop a Virtual Reality (VR) solution to experimentally assess the degree to which these factors influence DMA behaviour. Subsequently the project will develop a HF-rooted training curriculum and a corresponding VR training solution to provide a comprehensive framework for practical training for decision-making and acting under stress and in high-risk (DMA-SR) situations in order to improve performance.The training will increase DMA-SR performance which will lead to better and more correct decisions (from several perspectives, e.g. law, ethic, etc.), to keep the guidance in threatened situations, to minimise use of force occurrences, and accordingly, to maximise the avoidance of casualties and collateral damage, such as panic and cascading or escalating effects.SHOTPROS involves 6 law enforcement agencies (LEA) as it sees the capabilities of effective, efficient and “correct” DMA-SR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exercise system capable of evaluating human functional state during training and rehabilitation' under Fifth Framework.

assistant: **Concept**

Careful evaluation of physical condition during exercise, monitoring of physical exertion may reduce risk and increase efficiency of training actively. Presently, this is problem is resolved by qualified personnel evaluating physical condition before and during exercise. The overall objective is the training system capable of measuring, analysis, and predicting future developments of the functional state of a person, selecting training programme and monitoring it in the process of exercise. The system will increase safety during home-based exercise training and improve monitoring in fitness centres, athlete training facilities, or patient rehabilitation. The system will simultaneously evaluate the working periphery (muscles), supplying system (heart), regulatory system (central and humeral regulation). Novel organism function model and analysis algorithms will ensure advanced analytic and prediction capabilities. Flexible programme& exertion level regulation as well user-friendly interface will provide effective biofeedback.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Macro domain proteins in the cellular stress response and links to human disease' (MacDoPro).

assistant: **Concept**

The macrodomain is a ubiquitous protein module known to bind to ADP-ribose derivatives, which diverged through evolution to support protein functions involved in DNA repair and the maintenance of genomic stability, transcriptional regulation, cell signaling, telomere dynamics, necrosis and apoptosis. Derivatives of ADP-ribose are synthesized by NAD+-dependent protein modification enzymes poly(ADP-ribose) polymerases (PARPs) and NAD+-dependent protein deacetylases (sirtuins). PARPs attracted enormous attention over the past several years, when it was demonstrated that permeable PARP inhibitors are highly effective against hereditary breast and ovarian cancers, as well as against acute cardiovascular conditions such as myocardial infarction and stroke. Given the apparent impact and prevalence of these diseases, there has been a rapidly growing interest in the search for alternative targets operating in PARP-dependent pathways that can be explored in therapy. However, these efforts have been hampered by our lack of knowledge about the mechanistic basis of cellular processes regulated by PARPs. In the first two sections of this proposal we will focus on the characterization of the two human macrodomain proteins poly(ADP-ribose) glycohydrolase (PARG) and the chromatin remodeler ALC1 (Amplified in Liver Cancer) that act as mediators of PARP-dependent signalling and have been implicated in human disease. Furthermore, in the third section we will study the sirtuin-linked macrodomain proteins found exclusively in fungal and bacterial pathogens and analyze their importance virulence. Collectively, the aims of this proposal are to define the molecular mechanisms governing the ADP-ribosylation-dependent signalling pathways mediated by several macrodomain proteins that are implicate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Designed Nanoscale Heterogeneities for Controlling Water-Borne Pressure-Sensitive Adhesive Performance' (NSHAPE).

assistant: **Concept**

The proposal addresses needs of the European pressure-sensitive adhesive (PSA) industry, which makes unimportant contribution to Europe's economy and encompasses chemical suppliers, polymer producers, coating companies and end-users. Environmental and health restrictions on emission of organic solvents from industrial processes have driven development of water-borne Pass (by-Pass), which are based on colloidally-stableaqueous dispersions of polymer particles with diameters of 100-400 nanometres and whose composition, internal structure and surfaces can be controlled on dimensions of a few nanometres during synthesis. Due toothier socio-economic benefits, there is an increasing demand for by-Pass in high performance applications, particularly in the healthcare, aerospace and automotive, construction and assembly, and data tracking industries. A major problem for the PSA industry is that, in comparison to solvent-cast materials, by-Pass suffers limitations in adhesive strength and in their ability to bond to non-polar substrates. The proposed work programme will establish, through fundamental research, strategies by which the performance of by-Pass cane controlled so that these limitations can be overcome. A key strategy will be to synthesise particles designed to introduce nanometre-scale heterogeneities, which are expected to enhance adhesive performance by producing extensive, fine cavitations during depending. A second, related strategy is to synthesise particles with surfaces that are designed to adsorb at interfaces with substrates in order to increase the strength of adhesion, particularly to non-polar substrates. This fundamental study will inform the development of industrial-scale processes and prototypes for high-performance, commercially viable by-Pass. The ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'From heating and cooling strategies to action: how public authorities can strategically plan the decarbonisation of the heating and cooling sector and initiate impactful projects'.

assistant: **Innovation**

Heating and cooling (H&C) accounts for about half of Europe’s total energy needs with 75% still dependent on fossil fuels. Thus, rapid and significant change is needed to reach the EU 2050 goals. Due to the local nature of H&C systems, action has to be taken at local level involving a variety of stakeholders. This has been recognised in recent years and activities have been started like developing best practice policies and open source analysis tools. However, (efficient) H&C planning and project development are still not commonplace in most European municipalities.The objectives of Act!onHeat are to further disseminate and take up the concept and methods for strategic H&C planning, increase its quality and to push the development and implementation of identified measures. To reach these goals Act!onHeat will implement the following activities: (i) identify the success factors of strong and efficient existing H&C plans and develop a workflow for strategic H&C planning and project development based on the existing open source tools Hotmaps and THERMOS, (ii) support at least 120 municipalities in strategic H&C planning and the development of at least 30 pre-feasibility studies for related individual projects with a mix of tailored individual and group support activities, (iii) train stakeholders who can actively contribute to decarbonisation in the use of workflows, processes and tools through a dedicated training programme, and (iv) leverage additional impact with a mix of Europe-wide roadshow events, acceleration dialogues, webinars and further promotional activities.The consortium is perfectly suited for these activities bringing together leading European experts in strategic H&C planning and policy analysis, local governments networking, capacity building and investme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A multiple candidate-gene, high-density snp scanning approach to assessment of genetic susceptibility in chronic obstructive lung disease (COPD GENE SCAN)' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The proposal will evaluate a multiple candidate-gene, high density SNP (single nucleotide polymorphism) scanning approach to evaluation of genetic susceptibility in a complex, multifactorial disease of major socio-economic impact, namely, chronic obstructive pulmonary disease (COPD). Using state-of-the-art automated DNA sequencing combined with high-throughput homogeneous fluorescent technology, the project will identify all SNPs of frequency - 2% in six candidate genes for which there is sound genetic or biochemical evidence for a modifying influence in COPD and evaluate their prevalence in 1,000 COPD patients and 1,000 control subjects, matched for sex, age, ethnic origin and smoking history. Association of SNPs with disease susceptibility, severity and prognosis will be evaluated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Design and Implementation of an Advanced Nonlinear and Non-Gaussian Data Assimilation Algorithm for Bounded Variables in Numerical Weather Prediciton Models.' to be submitted under Horizon Europe.

assistant: **Abstract**

Hazardous weather events affecting populated coastal are among the most devastating natural disasters in terms of mortality and economical losses due to their low predictability. Currently, the generation of useful predictions, reliable and anticipated of hazardous weather events affecting populated coastal regions remains an ambitious challenge for the scientific community. Deficiencies in the accurate prediction of such events are tightly related with the initial value problem, which states that better the state of the atmosphere is estimated, the more accurate the forecasts. This problem is addressed by using advanced Data Assimilation (DA) techniques, which play an important role in current numerical weather prediction and is currently at the forefront of atmospheric and oceanic sciences research. However, although using the most current sophisticated DA algorithms, the estimation of the atmosphere is not accurate enough to improve the predictability of hazardous weather events, mainly because their linear and Gaussian underlying assumptions. The main aim of the present project is to go beyond the state of the art in DA by developing and implementing a novel and  advanced DA technique that takes nonlinearities and non-Gaussianities into account, enabling us to to improve high-impact weather forecasts. The new DA will be tested in real cases in combination with a high-resolution atmospheric model to improve the predictability of several poorly forecasted Mediterranean Hurricanes. This novel technique will significantly improve global, regional, and climate forecasts. The applicant’s strong mathematical and theoretical skills in DA together with his broad experience running numerical weather models using HPC facilities will facilitate the achievement of the key goals