RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Vibrational speckle tomography microscopy for fast intra-operative cancer tissue histopathology' (SpeckleCARS) under Horizon Europe.

assistant: **Objectives**

Histology is central to the diagnosis, staging, and treatment of cancers. It requires the removal of small regions of suspect tissues (biopsies) that are later sectioned and stained with haematoxylin and eosin (HE). However, histology suffers from major weaknesses: First the standard HE protocol cannot work in vivo and requires ex vivo biopsies. Second HE is labour intensive, time consuming and the final tissue sections inspection is possible only after 12 hours. A faster but less accurate protocol, known as extemporaneous histology, can be performed in 40 min and is used in an intra-operative context to guide surgeries. The SpeckleCARS project aims to develop for the first time fast label free tomography microscopy with vibrational sensitivity to provide images with tridimensional improvement as compared to extemporaneous histology and in near-perfect concordance with conventional stained HE histology. This pioneering approach overcomes all the previous challenges: Using a wide field reflection scheme and label free contrast rules out all the drawbacks due to tissue removal and external labelling. It provides instantaneous intraoperative 3D histological data, improving the accessibility and accuracy of tumour detection, diagnosis and treatment. Combining the latest advances in 3D tomography reconstruction algorithms, high power laser systems together with key innovations in random speckle illumination and hyperspectral vibrational imaging, the SpeckleCARS project will provide for the first time volumetric histology imaging in real time over large (mm) fields of view without the need of tissue removal. To demonstrate the power of the developed technologies both ex vivo human and in vivo mouse cancer assessments will be conducted in collaboration with pathologists. The S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Science, Technology and Policy interfacing using WISE-RTD' (STEP-WISE) under Seventh Framework.

assistant: **Objectives**

The aim of STEP-WISE is to promote and increase the use of FP environmental RTD results in the sector of environmental technologies focusing on water by diverse stakeholders: policy, scientists and industry.The WISE-RTD Web Portal (www.wise-rtd.info) has already been implemented to serve as a dissemination tool, linking diverse EC Water Framework Directive policy aspects to FP RTD (and LIFE) results, thus bridging the science policy gap in information exchange. Amendment of WISE-RTD to include also other (EC) Directives that relate to water policies will expand the current set of intricate algorithms that define science-policy interactions. In addition, the WISE-RTD structure will be expanded with environmental technologies focusing on water (WISE-RTD+ Web Portal).FP (and LIFE) funded environmental research projects and results with high EU added value will be identified and selected using preset criteria. By uploading these projects/RTD results using a dedicated tool WPIS (Web Portal Input System) to the WISE-RTD+ Web Portal, the information automatically become linked to the diverse sets of policy instruments (i.c. Directives).The WISE-RTD+ Web Portal will be used to evaluate whether policy questions have been answered by the RTD outcome (top down, scientific support to policy), and whether needs from identified stakeholders, e.g. from the environmental water technologies sector, are covered by policy issues (bottom-up). Merging of these two approaches will form the gap-analysis, recommendations towards a better uptake of FP environmental RTD results with tangible impact on economic growth and social welfare.The policy and science related contents of WISE-RTD+, and the two-way gap analyses will form the basis for dissemination using different user-friendly media. Inno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Metal-Mediated Methods for the Functionalization of White Phosphorus (P4)' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Organophosphorus compounds are an important and industrially relevant class of molecules with numerous uses, e.g. as reagents in organic synthesis, ligands in catalytically active metal complexes, and in pest control. State-of-the-art synthesis methods for all these valuable and useful compounds rely on an atom inefficient and hazardous multi-step procedure involving the oxidation of white phosphorus (P4) with toxic chlorine gas. Less wasteful and more environmentally benign methods are highly desirable, but transformations of white phosphorus directly into organophosphorus compounds are hardly developed.This project explores new methods for the activation and functionalization of white phosphorus. The metal-mediated stepwise transformation of P4 into organophosphorus compounds is a key objective. Novel transition metal compounds are designed and synthesized, which can generate reactive phosphorus units. The concept of heterobimetallic P4 activation, where two electronically different metal complexes interact with P4 cooperatively, is introduced for this purpose. Reactions of the phosphorus fragments in these new, reactive complexes with electrophiles will produce novel, fundamentally interesting organophosphorus compounds avoiding chlorinated intermediates. Catalytic methods for P4 functionalization are currently unknown, and developing such methods using transition metal and photoredox catalysts is an additional objective of this proposal.By providing novel synthetically useful and even catalytic procedures for converting P4 into organophosphorus compounds, this project will significantly contribute to the development of phosphorus chemistry and more sustainable synthesis methods.


**Keywords:** phosphorus,  transition metal compounds,  inorganic chemistry,  organome
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Raising European Student Awareness in Aeronautical Research Through School-labs'.

assistant: **Objectives**

‘Raising European Students Awareness in Aeronautical Research Through School-Labs’ is the main objective of the project REStARTS. The objective of the project is to contribute in reversing the current trend of disinterest of young people towards aeronautics. In this project, the partners of the aeronautical research and training institutes develop informative material about current research topics in aeronautics including basic aerodynamic fundamentals like ‘How does an airplane fly?’ or special challenges the aeronautical research is facing like ‘How greening air transport?’ or ‘How to ensure satisfaction, safety and security of the passengers?’ .This demonstrates the direct link between research and society. The scientists work in cooperation with a pedagogic team and teachers of local schools to compile understandable teaching material, which also includes simple experiments to demonstrate the physical phenomena being investigated. The school lessons based on this material give a first impression of the challenges of the modern aeronautical research. The school-labs established at the research institutes provide more sophisticated experiments and enable school classes to get a hands-on experience in scientific work. Additional visits of the laboratories of the project partners and their industrial partners complete the program. This will build bridges between school theory and applied research by delivering an insight to the work of research organisations. The ambition is to stimulate young people’s interests in a R&D career in aeronautics and to create a European network of Aeronautical School-Labs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Species Identification Methods From Acoustic Multifrequency Information'.

assistant: **Concept**

The overall goal of the project is enhance fisheries management through improved fish stock surveys by enabling the identification of fish species using acoustic methods. The project will apply modern multifrequency fisheries acoustic1h techniques, in addition to the single frequency methods available previously, to establish methods for acoustic species identification of echo traces that are applicable to routine survey procedures.The project will: 1) construct an echogram library; 2) apply single-frequency extraction / identification methods on multifrequency data; 3) develop multifrequency algorithms for the differentiation of fish from plankton and for the identification of fish (with and without swim bladders); 4) combine these techniques in a generic algorithm for plankton and fish stock identification.The project will specifically target the identification of fish that are prevalent in the partnerships survey programme. These encompass both those fish which are targeted for stock assessment purposes (the primary species) and other secondary species, which although not required from acoustic surveys for assessment purposes, nonetheless need to be considered in order to differentiate from primarys. The primary species are anchovy, herring, horse mackerel, mackerel, sandeel and sardine; secondary species include blue whiting, bogue, capelin, cod, chub mackerel, haddock, Norway pout, sprat and whiting.The work will concentrate on: (1) Construction of an echogram library of ground-truthed multifrequency echograms of fish species from historical survey data going back at least five years to be augmented during the course of the project from survey data. This library, containing raw acoustic data, biological information and environmental parameters will form the core da
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'From Quantum Field Theory to Motives and 3-manifolds' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Quantization has been a potent source of interesting ideas in mathematics. This project aims to investigate a series of problems in pure mathematics, all having their roots and solutions in perturbative quantum field theory (pQFT). Below is a brief description of these subprojects.* Motivic Renormalizations:This project proposes to study motivic aspects of renormalization in order to understand number and homotopy theoretic properties of perturbative quantum field theories. The focal point of this project is to answer the main open problems of the field; explaining the presence of multiple zeta values and proving that pQFTs are indeed form  E_d-algebras.* Algebraization of 3-manifolds:This project proposes a combinatorial reconstruction of 3-dimensional manifolds out of certain Feynman graphs and connections to bialgebras. This approach can be seen as a 3-dimensional generalization of the theory of Strebel differentials. It suggests a set of new invariants of 3-manifolds and their connection to the known ones (such Turaev-Viro, Reshetikhin-Turaev, finite type invariants). This combinatorial construction should also be related to a tensor model that is a generalization of Kontsevich’s matrix model in and such a model will be able to provide fundamental topological characteristics as Kontsevich’s model does in dimension two.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'CALCULATION OF MECHANICAL, THERMAL, DIELECTRIC, AND OPTICAL PROPERTIES OF NANOTUBES USING PHENOMENOLOGICAL, TIGHT-BINDING, AND AB-INITIO APPROACHES'.

assistant: **Concept**

The recently discovered carbon annotates have shown a variety of unusual properties mainly due to their quasi-one-dimensionality and canonize. The speculations for possible technological applications of the annotates have directed the efforts of experimentalists and theoreticians towards the understanding of the production process and modelling of the physical properties of the annotates. Currently, there is a worldwide competition in the field with centres of excellence in Europe, America and Asia. Europe can effectively gain and keep leadership in this field through fostering the annotate research both on basic and technological level. The main objectives of the proposed research project are the theoretical and computational study of the mechanical, thermal, dielectric and optical properties of annotates, especially, elastic module, specific heat, resonant Raman scattering, light absorption and reflection. The study will include isolated and bundled, single-walled and multiwalled annotates, with different elemental composition - carbon, boron, nitrogen, etc. The computational results will be used for the assignment of experimental Raman and optical data and for the needs of industrial applications. The theoretical approach is based on an idealised model of a annotate as a system with specific space symmetry. First of all, accounting for this symmetry allows for drastic reduction of the computational efforts and enables one to encompass almost all experimentally observed annotates. Secondly, the use of the annotate symmetry yields directly phonons or electronic eigenstates labelled by the irreducible representations of the annotate symmetry group. Thirdly, the calculations of all annotate properties due to phonons and electrons are largely facilitated. The proposed pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Generative European Commons Living Lab' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

gE.CO Living Lab aims at creating a platform for bringing together and supporting formal groups or informal communities of citizens who manage fab-lab, hubs, incubators, co-creation spaces, social centres created in regenerated urban voids. These innovative practices are considered generative commons, because they are based on sharing and collaboration between citizens and establish a new partnership between Public Institutions and local communities, setting forth new models of governance of the urban dimension based on solidarity, inclusion, participation, economic and environmental sustainability. However, these experiences design a scattered scenario of different legal and economic models which scalability is extremely difficult without appropriate tools. Also, their support through the traditional means of the public runs the risk of compromising their participatory character.To fill these gaps gE.CO built a consortium of experts: Universities and non-profit and for-profit organizations in order to: i) bring together generative commons using a digital platform for collaboration that will map citizens’ initiatives as well as those Public Institutions engaged in new forms of partnership with local communities. This way, generative commons and Public Administrations can finally be connected in a new network able to promote the exchange of good practices and legal solutions; ii) evaluate a group of pilot cases in order to understand which socio-economic, cultural and legal factors make self-organized experiences sustainable and Public Institutions helpful for their development; iii) use the results of the evaluation for scaling up sustainable generative commons and innovative local policies: best practices, recommendations as well as legal solutions will be developed fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Defining hormonal cross-talk and the role of mutations in estrogen receptor positive breast cancer' in the context of a Horizon 2020 call.

assistant: **Objectives**

Estrogen Receptor (ER) is the driving transcription factor in ~75% of all breast cancers. ER antagonists are routinely used for treatment, but significant variability exists in clinical response. We are interested in explaining this heterogeneity and exploiting the mechanistic insight. We have recently identified important, but previously uncharacterised cross-talk between ER and the progesterone receptor (PR) and androgen receptor (AR) pathways, both of which are commonly expressed in ER+ tumours. Recently, ER has been shown to be mutated in ~18-55% of metastatic breast cancers. In addition, two key ER-chromatin regulatory proteins, FoxA1 and GATA3, are mutated in primary ER+ disease. Finally we have discovered three previously unknown phosphorylation events on FoxA1. Aim 1: We will comprehensively explore the cross-talk that exists between ER and PR and AR pathways to determine the physiological effects on ER function. Aim 2: We will recapitulate the key mutations observed in ER, FoxA1 and GATA3, to assess the impact on ER-DNA interactions, ER transcriptional activity and cell growth and drug response. This will be explored under different hormonal contexts to identify how the mutational spectrum influences the cross-talk between ER and the parallel PR and AR pathways. Aim 3: We will identify upstream kinase pathways that influence FoxA1 and GATA3 function. Aim 4: We will establish a novel single locus chromatin purification method for isolation of specific chromatin loci, followed by Mass Spectrometry to characterise the potential role of PR and AR variants and to identify unknown regulatory factors. Given recent biological discoveries and technological advances, we are perfectly positioned to apply cutting-edge tools to glean mechanistic insight into the factors tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Engineering Network and Interference Geometry for the Analysis and Design of Next Generation Wireless Networks'.

assistant: **Concept**

Today, our society, industry and service sectors are increasingly becoming more dependent on information and communication technologies (ICT) in general and wireless telecommunication networks in particular. For example, fourth generation (4G) wireless networks has transformed mobile handsets into intelligent terminals for providing an easy anytime-anywhere access to all sorts of information and services in our daily lives such as location tracking, high-definition video streaming, and portfolio monitoring and management. ICT empowered with next generation wireless protocols for machine-to-machine communication is expected to decrease total greenhouse gas emissions from all industry sectors by 15%, and to advance current medical and public health practices significantly within the next decade.Such a wide range of application areas brings together new interoperability challenges for heterogeneous network architectures and requires innovative approaches for interference mitigation to support data rates as high as 1 Gbits/sec in low mobility and 100 Mbits/sec in high mobility environments. This project will engineer network and interference geometry to derive fundamental performance bounds and to mitigate interference for next generation heterogeneous wireless and complex networks. It will combine stochastic geometry and random geometric graphs with the theory of complex networks, nonlinear optimization and advanced distribution approximation techniques to discover hidden dynamics and underlying fundamental properties peculiar to these networks. Novel, distributed, practical and provably optimal or near-optimal algorithms will be devised to manage and control heterogeneous wireless and complex communication networks, as well as safeguarding them against unexpected failures