RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Immune interactions' in the context of a Fifth Framework call.

assistant: **Objectives**

Communication via hormones and cytokines at the brain-immune interface regulates immune functioning as well as central nervous system activity. Cytokines and hormones act both in the central nervous system and in the immune system via shared receptors and signalling pathways. This field has known an enormous growth since the early nineties, with the demonstration of the existence of a brain cytokine compartment and a neuropeptide immune compartment. Studies on the regulation of these compartments have proliferated over the years and clinical implications are beginning to emerge.The first aim of the meeting is to bring together researchers that study hormone and cytokine signalling in the immune system with researchers that study these processes within the central nervous system. The second aim of the meeting is to discuss clinical implications of hormone and cytokine action within the immune system and the brain. The basal knowledge on signalling mechanisms will contribute to the understanding of pathology involving hormone and cytokine signalling.Ultimately, understanding the signalling pathways used by cytokines and hormones in the two systems is important to develop therapeutic strategies for diseases that are caused by dysfunctions within these regulatory systems and their communication pathways. Sessions will be organised on Cytokines in the brain, Hormone and cytokine signalling in brain and immune system, Hormonal regulation of cytokine production, Cytokines and hormones in chronic inflammation, Central and peripheral cytokines and Steroids and cytokine balance in health and disease. Scientists from the areas of cell biology, immunology, endocrinology, pharmacology, neurology, internal medicine, physiology and behaviour will be brought together in an environment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'INNOVACTIS 2019' (2014-2020).

assistant: **Innovation**

The objective of this project is to provide innovation support services in 2019 to SMEs in the regions covered by the consortium members. These innovation support services will be differentiated for two groups of SMEs:a) SMEs that have been selected as beneficiaries of the SME Instrument (Phase 1 or Phase 2), FTI or FET-Open funding schemes. For these companies, the consortium members will offer Key Account Management (KAM) services, which are accompanying services for the SMEs to identify weaknesses in their innovation capacities and suitable external coaches throughout their participation in the SME instrument.b) SMEs that have high potential for growth and internationalisation but that need to improve their innovation management capacities. These companies will receive direct assessment services from the consortium members in order to detect barriers and develop and implement an action plan in order to enhance such capacities and overcome the detected barriers.


**Keywords:** SME INSTRUMENT, FTI, FET-Open, KAM, EIMC, innovation, innovation management
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Engineering and Delivering B Cells Using Biomaterials against Breast Cancer' (END-BC).

assistant: **Concept**

Breast cancer (BC) is the most diagnosed cancer worldwide, and despite treatment availability, the disease remains challenging to treat, causing substantial adverse side effects and fatalities globally. The lack of efficacy and inaccessibility of standard care supports this demand for better treatments. This is demonstrated by resection surgery and current (neo)adjuvant therapies such as chemotherapy exhibiting inadequacies resulting in 30% of BC patients having metastases. These percentages are even higher in low human index regions due to inaccessibility, cost and growing populations. Adoptive cell therapy (ACT), such as CAR-T, is a category of emerging immunotherapies expected to impact oncology by transferring engineered immune cells into a patient to eliminate cancer cells. However, these treatments are currently ineffective in BC and costly.END-BC will complement research into B cells to produce an ACT that improves treatment efficacy against breast cancer while reducing side effects and costs from effective therapy. Our research developed novel biomaterial to overcome significant obstacles to successfully enhance B cell functions against cancer using a low-cost method. In END-BC, we will research the commercial and technical feasibility of tailoring the B cell ACT with biomaterials to determine its potential to treat BC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Increasing Sustainability of European Forests: Modelling for Security Against Invasive Pests and Pathogens under Climate Change' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

European forests are under unprecedented threat from the combined forces of climate change and large increases in the numbers of alien invasive pests and pathogens resulting from changes in patterns of global trade. Interactions between climate change, including likely changes in both mean temperatures and precipitation, will have serious impacts on the susceptibility of forest ecosystems to damage by pests and pathogens, and a large number of novel, unprecedented forest health problems are likely to occur in the near future. These problems will lead to reductions in primary production, with consequent losses in yields, biodiversity and other multi-functional roles of forests. Local extinctions of highly susceptible plant species may also result. The ISEFOR project will address these problems through:  the identification of key groups of potentially invasive alien organisms,  the development of accurate, state-of-the art diagnostic methods to detect and quantify both known and unknown threats,  an in depth analysis of the plant nursery trade, the major poorly controlled pathway for distribution of alien pests and pathogens, and  through the development of modelling software enabling the prediction of geographical areas at risk of attack by alien invasive pests and pathogens under climate change scenarios. The efficacy of the ISEFOR project will be enhanced through the use of the recently developed large databases of alien pest and pathogen threats, and interfacing with other EU-funded projects dealing with plant health issues. Results will be directed to the national plant protection organisations through targeted workshops.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The response of Lactococcus lactis to reducing environmental conditions' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Lactococcus is a commercially important microorganism. It is used widely in the dairy industry. Cheese quality depends on the raw material, starter cultures and fermentation conditions (T, humidity, NaCl and pH). Redox potential has an important role in the final properties of fermented dairy products, especially their aroma. One possible explanation is the observed effect of redox potential on amino acid catabolism.   The improvement of Lactococcus for industrial purposes involves identifying and controlling the global regulatory circuits responsible for the environmental stress response. In aerobic environments, many metabolic reactions in the cell depend on the balance between oxidative and non-oxidative states which can regulate enzyme activity. Toxic radicals formed by oxygen cause cellular damage and may result in cell death or alter growth. Resistance to these negative effects includes maintaining the redox balance within the cell and the production of detoxifying enzymes.   Lactococcus lactis is known for its powerful reducing activity in milk which occurs before acidification. But little is known about what these activities are and how they are controlled. Our hypothesis is that the acidification kinetics and growth can be altered by manipulating the environmental redox potential. We will investigate this by separating the effects of oxidation stress produced by oxygen from those produced specifically by redox potential.   Environmental stress response is a complex process that can only be addressed by a genome-wide search for the individual but interlinked components. This project will combine physiology, biochemistry, molecular genetics and transcriptome analysis. It will result in new information on redox regulated genes in Lactococcus lactis. This knowledge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Socio-spatial inequality, deprived neighbourhoods, and neighbourhood effects' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The objective of DEPRIVEDHOODS is to come to a better understanding of the relationship between socio-economic inequality, poverty and neighbourhoods. The spatial concentration of poverty within cities is of great concern to national governments, partly based on a belief in neighbourhood effects: the idea that living in deprived neighbourhoods has an additional negative effect on residents’ life chances over and above the effect of their own characteristics. This belief has contributed to the development of area-based policies designed to introduce a more ‘favourable’ socio-economic mix in deprived neighbourhoods. Despite the persistent belief in neighbourhood effects, there is surprisingly little evidence that living in deprived neighbourhoods really affects individual lives. There is little consensus on the importance of neighbourhood effects, the underlying causal mechanisms, the conditions under which they are important and the most effective policy responses. It is likely that most studies claiming to have found that poor neighbourhoods make people poor(er) only show that poor people live in poor neighbourhoods because they cannot afford to live elsewhere. DEPRIVEDHOODS will break new ground by simultaneously studying neighbourhood sorting over the life course, neighbourhood change, and neighbourhood effects, within one theoretical and analytical framework. This project will be methodologically challenging and will be the first integrated, multi-country research project on neighbourhood effects to use unique geo-referenced longitudinal data from Sweden, United Kingdom, Estonia, and The Netherlands. Special attention will be paid to the operationalization of neighbourhoods and how it affects modelling outcomes. Through its integrated and international approach, DEPR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Launching high-resolution relaxometry - A powerful new analytical tool for industry'.

assistant: **Concept**

Analytical methods are essential in many industries, such as chemistry, energy, pharmaceutical, and in health services. These methods usually fall into one of two categories: they either identify molecules and their structures or determine the properties of a fluid or a solid. This project will introduce a game-changing method to industry: high-resolution relaxometry in NMR, a label-free method, which combines both approaches as it identifies molecules and characterizes their individual properties within a complex fluid.  The main goal of this project is to open a new market for high-resolution relaxometry instrumentation and methods in industry and health services. We have developed innovative hardware, methods, and software for applications of high-resolution relaxometry in biophysics during our ERC StG project. Introducing high-resolution relaxometry to industry will vastly expand what is currently a small budding market for academic users. This project will be carried out with our long-term partner, Bruker Biospin, the world leader in NMR instrumentation.  Our strategy is to (1) identify competition and sectors of industry and high-potential end users that will benefit from this ground-breaking method; (2) improve the relaxometry hardware; (3) collaborate with target companies, including initiated work within the chemistry/energy and the pharmaceutical sectors, as well as a laboratory with links to health services; (4) demonstrate the potential of high-resolution relaxometry (e.g. better characterization of raw materials, enhanced processes, or new information for medical diagnostics). This strategy will lay the ground for the commercial deployment of high-resolution relaxometry in industry and health services. Overall, this project will have significant economic im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Parallel Lives: Dependency and Backwardness' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

This project will investigate the relationship between economic development and global trade in the twentieth century. It will explore the connection between two alternatives to neoliberalism posed in the second half of the twentieth century: Soviet economic thinking and “dependency theory”, the predominantly Latin American approach that stressed the structural inequality between a rich “core” and a poor “periphery” of countries. The project will interrogate the intellectual and practical connections between the two, exploring the influence of Soviet economic thinking on some of the most influential thinkers on dependency and development. In particular, this proposed project will look at the debate in the USSR on the idea of “backwardness”, which socialism was supposed to overcome, and its impact on two of the founding fathers of dependency theory, the Argentinian Raúl Prebisch and the Brazilian Celso Furtado. Moreover, the project will investigate the significance of this transnational exchange of ideas for the development of global trade policy through two organizations that pushed for trade reform: the Economic Commission for Latin America (ECLA) and the United Nations Conference on Trade and Development (UNCTAD). The overarching argument is that dependency theory, both as an abstract concept and as a policy embodied by ECLA and UNCTAD, borrowed and re-elaborated many key ideas from the socialist tradition, through the mediation of Soviet texts and Soviet participation in international debates. The project will add a new crucial dimension to European research on the international circulation of economic ideas, which currently still lags behind the US in this field. Moreover, the proposed research will offer precious insights on the management of global and regional t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Transnational Fatherhood, Negotiating Masculinity and Parental Care in the Digital Communication Era' in the context of a Horizon Europe call.

assistant: **Objectives**

The research proposal aims at investigating the relationship between transnational fatherhood, negotiation of masculinity, and parental care practices among Pakistani migrant men in Italy. The migration patterns prompted by socioeconomic factors, traditional gender roles, and improved quality of life in certain regions have led to a surge in migration predominantly by men. This study seeks to explore how transnational fathers navigate their roles across family, work, and society and use digital communication tools to maintain family connection.Guided by an intersectional perspective and innovative methodologies, this research project focuses on the experiences of Pakistani migrant men. The research objectives include investigating the impact of transnational fatherhood on the construction and negotiation of masculinity, exploring the role negotiation of migrant fathers, understanding the interplay between migration, masculinity, emotions, and transnational fatherhood, and analyzing how digital communication technologies influence fatherhood and care practices.By focusing on Pakistani migrant men, this research addresses a critical gap in the literature surrounding masculinity, fatherhood, and emotional care. In light of the statistics revealing the substantial influx of male migrants, particularly from South Asia, this project becomes pivotal for addressing this.The research design employs a variety of qualitative methodologies including in-depth interviews, focus group discussions, observations, and content analysis. The primary and secondary sample respondents consist of Pakistani migrant men with and without families in Italy, Italian natives interacting with Pakistani migrants, field experts and other stakeholders. The sampling strategy involves purposive selection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Safeguarding Cell Fate by Terminal Repression during Development and Disease'.

assistant: **Concept**

Cell identity and function requires both induction of desired genes and repression of unwanted programs. While master regulators that activate gene networks during development are well characterized, the mechanisms that terminally repress alternative fates remain poorly understood. Within this project, I aim to demonstrate that active terminal repression is a universal mechanism required to prevent loss of cell identity and disease.We recently found that the neuron-specific transcription repressor Myt1l is essential to induce neuronal cell identity. Myt1l is expressed in virtually all neurons throughout life and its loss in mature neurons impairs neuronal gene expression and function, suggesting a role in maintaining cell fate. Unlike known repressors such as REST that specifically silences neuronal genes in non-neuronal cells, Myt1l represses many non-neuronal programs in neurons. I therefore propose that a new class of terminal repressor exists that continuously represses alternative lineages to confer and maintain cell identity.Since Myt1l mutations often occur in autism and schizophrenia I will investigate how loss of terminal repression can contribute to these poorly understood but common mental disorders. This will require molecular and behavioural studies in human and mouse models. We will also investigate how a sequence specific terminal repressor biochemically interacts with general epigenetic machinery to continuously silence unwanted programs during neuronal reprogramming. Finally, we will test candidate terminal repressors in other lineages by loss and gain of function approaches to analyse whether terminal repression is a universal principle of biology. Ultimately this will provide insight into fighting diseases associated with loss of cell identity and to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'REAL TIME MOLECULAR IMAGER WITH UNSURPASSED RESOLUTION'.

assistant: **Concept**

Over the last decades, Positron Emission Tomography (PET) has been firmly established as the predominant molecular imaging technique due to its unmatched sensitivity and capability to address many different metabolic processes. However, there is huge room for improvement, as current clinical PET scanners are limited to spatial resolutions higher than 2.5 mm and temporal resolutions longer than 5 seconds. This hampers applications of PET for preclinical research and clinical diagnosis in small tissues or lesions and precludes real-time reconstruction of metabolic images. RETIMAGER is a proposal for a molecular imaging system with a ten-fold spatial and temporal improvement on the reconstructed image with respect to current PET devices. This will not only boost the quantitative performance, but it will enable new applications in cardiology, vascular oncology, oncology, neurology, and other areas. We will achieve this milestone by developing smart radiation detectors with non-conventional geometries that combine the advantages of both pixelated and monolithic detectors, the two dominant and seemingly incompatible technologies employed in PET scanners. Our new scanner will provide 0.25 mm pixel resolvability with time frames as short as 0.01 sec. By aggregating these blocks in a unique gantry self-adapting to the geometry of the field-of-view, RETIMAGER will achieve an unprecedented increase in sensitivity and in in vivo real-time imaging with submillimeter resolution. We will pair it with high-throughput data processing and AI tools to assess with a single tracer both perfusion and metabolism in preclinical and clinical models. In the long run, RETIMAGERs faster, lower dose, and less invasive molecular imaging technology will become a game-changer for understanding disease