RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Streamlined Geriatric and Oncological evaluation based on IC Technology for holistic patient-oriented healthcare management for older multimorbid patients'.

assistant: **Innovation**

Population is aging and the number of complex multimorbid patients to manage will increase sharply. Disease centred approach is not optimal or appropriate to manage this patient group’s inherently complex needs. Change to a patient centred approach will simplify care pathways, secure management and treatment decision- making and decrease healthcare costs. A practical, validated, clinically-appropriate, structured care pathway will be a practical, clinically impactful, and valuable breakthrough for daily practice with multiple impacts that must be quantified. GERONTE multimorbid patient-centred system proposes: 1) Coordination of management by a patient-tailored, interdisciplinary health professional consortium (HPC), including hospital- and home-based professionals, with a case manager; 2) Timely registration of symptoms and patient-reported outcomes at home through anapp for anticipation of avoidable adverse events; 3) Proposal of self-management guidelines according to intrinsic capacity evaluation by geriatrician for patient driven improvement of independent living; 4) Structured collection of data from electronic health records into a dashboard made available to HPC members as well as patient and caregiver, thanks to its capacity to securely interoperate with all electronic health records including software managing medical data. The whole approach will be co-designed with patients, informal caregivers and health professionals. Cancer is an excellent model to develop this approach in multimorbid patients because it is frequent and commonly associated with other morbidities in older patients but also because of its major impact on patients’ general status and coexistent diseases. Cancer already benefits from a multidisciplinary management model that GERONTE will eval
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Isopren' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The programme of 19th Conference on Isoprenoids is focused on chemistry, biochemistry, pharmacology and practical applications of natural products that are biosynthetically related to isoprene: human and animal hormones, plant hormones, semiochemicals (signal substances" of insects and animals), anti-cancer drugs (for example, TaxolR, vitamin D metabolites) and other important biologically active substances, as vitamin A, cardiotonic glycosides, terpenes with anti-cholestemic activity, some alkaloids and antibiotics. Studies on isoprenoids are presented in a complex way embracing techniques of isolation from animal or plant material, structure elucidation, chemical transformations, total synthesis, biochemical characteristic, pharmacology, medical and agricultural applications, chemical ecology. The conference provides theoretical and methodological backgrounds to the natural products chemistry and reflects progress in whole organic and bioorganic chemistry. Emphasis is given to the following topics: 1) Progress in the analytical methods that allows new approaches to studies on the natural products including studies on the interactions between insects and plants, 2) New biologically active compounds from plant and animal sources, 3) New trends in the field of organic synthesis that aim at selectivity of transformations, 4) Biochemical studies that promote molecular modelling, 5) Chemical ecology. The conference is scheduled for five days.Programme of the Conference embraces the following main activities: 1) Plenary and invited lectures, 2) Oral communications, 3) Poster communications 4) Discussions and personal contacts between the participants."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The role of filopodia in synapse formation in absence of dendritic spines' (2002-2006).

assistant: **Innovation**

One of the fundamental questions in neurobiology is how synapses are formed. Dendritic filopodia are thought to play an important role in the generation of excitatory synapses on dendritic spines.They find and make initial contact with an appropriate axon and then retract to the dendrite and become spines. Much less is known about the role of filopodia - if any - in the generation of synapses on the dendritic shaft.The aim of the proposed project is to elucidate this process by following the formation of shaft synapses using two-photon laser scanning microscopy. Most studies on synapse formation have concentrated on excitatory synapses, but I will examine inhibitory synapses, which never occur on spines.Postsynaptic dendrites of pyramidal cells and GABAergic axons will be visualized with different fluorescent labels in hippocampal slice cultures by filling individual neurons and/or by using transgenic mice that express Green Fluorescent Protein (GFP) in a specific subset of neurons.I will follow the morphological changes of the axon and dendrite at locations where they make contact. The formation of functional synapses will be verified by FM1-43 labelling, which marks presynaptic terminals that recycle vesicles. Once the initial events in GABAergic synapse formation under control conditions have been established, I will assess the regulation of these events by factors that are known to have an effect on GABAergic synapse formation.Such factors could be pharmacological agents such as TTX, bicuculline and BDN F, or postsynaptic Cl- concentration. The results of the proposed experiments will lead to a better understanding of the initial steps in GABAergic synapse formation and factors influencing this process.This will contribute to the understanding how neuron al networks
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Skill-based Inspection and Assembly for Reconfigurable Automation Systems'.

assistant: **Innovation**

Motivation:Today, large-scale manufacturing facilities are characterized by a high degree of automation whereas the reconfiguration of these complex production processes is accomplished by extensive engineering. With increasing product variants and shorter product cycles, the dynamic reconfiguration clearly is a key technology. Current production engineering tools maintain their own models of equipment capabilities which leads to problems of consistency and scalability.Objectives:The main project objective is to facilitate dynamic reconfiguration of complex production processes. To this end, the novel concept of skill-based manufacturing is proposed, i.e., production units with embedded knowledge about their skills being able to interact in order to solve a given manufacturing task. Three scientific and technical objectives have been identified: skill-aware components (sensors/actuators with embedded knowledge about their skills), skill-serving (matching production requirements and component skills for dynamic reconfiguration) and skill-mining (real-time query of capabilities of production facility).Innovation:The approach of skill-based production will trigger innovation along the whole chain of manufacturing. Information technology will no longer only be used for the control of production facilities but also for their set-up and reconfiguration. All manufacturing devices will be equipped with embedded intelligence enabling interaction and co-operation between them.Impact:The collaboration of research institutes (3), SMEs (3) and global players (2) will promote the idea of skill-based manufacturing, thus contributing to the transformation of industry towards high-added value organisations. In the future, additional services such as web-based configuration tools will op
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Control of current-induced heat exchange in molecular junctions by molecular scale design of the electronic properties' under Horizon 2020.

assistant: **Concept**

The project will investigate the current-induced vibrational heating and cooling of molecular junctions with relatively sharp molecular resonances. These systems are interesting because, depending on the atomistic details of the metal/molecule interface and the chemical structure of the molecule, an extremely rich variety of heating/cooling dynamics under an external bias is possible.A detailed study of the connection between the electronic structure (both at equilibrium and in presence of a bias) and the inelastic processes associated to the emission and absorption of molecular vibrations represents a necessary step toward the comprehension and control of the junction heating and cooling dynamics and thus of its stability.We will study a broad range of systems where the sharp DOS features are originated by two different physical mechanisms: i) structural and chemical details of the metal/molecule interface, and ii) destructive interference in the molecule.In the first case, we will focus on the effect of electrode shape on the heating and cooling of the molecule and consider a wide range of molecule-electrode couplings. The molecules we will consider are examples of these classes of systems, namely carbenes (strong coupling to the electrodes), bypiridine (intermediate coupling), PTCDA (weak coupling).In the case of destructive interference, we will focus on conjugated linear molecules where quantum interference features originate from the coupling of side-groups to the molecular backbone.Finally the project will extend the state-of-the-art approach for the calculation of the heating and cooling dynamics by introducing self-consistency between vibrations populations and the electronic structure. For this we will make use of a series of approximations in the derivation o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Innovative training in methods for future data' (IMforFUTURE).

assistant: **Concept**

IMforFUTURE is an innovative multidisciplinary and intersectoral research training programme which addresses current shortcomings in omics research. We aim to open the new research horizon in integration of genetics, glycomics, and epigenomics datasets into systems biology by developing innovative methods for high throughput omics and for integrative analysis of omics data. We focus on ageing, which is the biggest single risk factor for many diseases. By application of our novel methods to emerging datasets representing inflammation and immunology, IMforFUTURE will contribute to understanding of the underlying biological processes involved in diseases and ageing.To be successful in future multidisciplinary environments in Academia or Industry, ESRs need to be able to act as bridge between several diverse disciplines. Our ESRs need to overview all steps from data production via data analysis to data interpretation. In our consortium 7 academic and 4 industrial partners - experimental and theoretical - participate in research and training via teaching, offering secondments and hosting ESRs. We offer courses in high throughput methodology, genomics and statistics. Secondments will be to partners with complementary disciplines and intersectoral. Emphasis will be data management,  data stewardship, entrepreneurship, and complementary skills. Interdisciplinary collaborations among ESRs will be stimulated by working on the same studies, in which new data will be generated, integrated with other datasets, analyzed with novel methods and interpreted. At the end of the project the ESRs will present and discuss their research in an integrated workshop. Our ESRs will be ready and equipped for new-generation multidisciplinary researchers. They will significantly contribute to omics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Scale-up of an Advanced Manufacturing process to produce a Pharmaceutical product Application (SAMPA).' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Sublimity Therapeutics has developed an innovative product, ST-0529, to treat patients with moderate-severe Ulcerative Colitis, a disease that affects 1 million patients in Europe. ST-0529 is enabled using Sublimity Therapeutics ’s proprietary SmPill® nanoemulsion-based technology to target a known and powerful drug, Cyclosporine, directly to inflamed colons. In Phase II human studies, ST-0529 was proven to be effective and safe.  ST-0529, an oral product, will compete with injected, expensive drugs that have a risk of serious side effects.Successful development and commercialisation of ST-0529 will pivot on development of a stable ST-0529 product and a positive outcome of the clinical trials. Overall, the project will involve leading EU-based specialist SME, technology and equipment suppliers as well as a number of knowledge providers. The budget is €1.6M and will be completed in 58 months. Successful completion of this project will retain and enhance intellectual property and know-how in Sublimity Therapeutics, increase long term high skill jobs. In parallel, the project will unlock the value inherent not only of ST-0529, but also the underlying SmPill® technology platform. Furthermore, the project will increase the probability of overall company success and increase significantly the NPV to more than €500M.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Scaling up behavior and autonomous adaptation for macro models of climate change damage assessment' (SCALAR).

assistant: **Innovation**

Damage associated with climate change is a core benchmark in science and policy. Macro Integrated Assessment Models estimating damages are criticized for neglecting risk distribution, adaptation dynamics and the possible collapse of regional economies. Micro-level social science studies contain substantial knowledge on individual behavior, decisions under risk and autonomous climate adaptation, and go beyond monetary losses by focusing on resilience. This knowledge can ameliorate theoretical and empirical flaws in current macro assessments, if adequate scaling up methods were to exist. SCALAR aims to bridge the gap between micro and macro research traditions by modeling the behavioral aspects of autonomous adaptation processes of heterogeneous agents, and integrating them into macro level climate policy models. The project focuses on floods. Its innovative nature allows to revisit the classic micro-macro aggregation problem through a unique combination of:1) New behavioral data on climate adaptation decisions collected in multiple survey waves using mobile applications, going beyond a snapshot to uncover evolving decision processes;2) Advances in agent-based modeling to scale up adaptation decisions of heterogeneous households and firms to a regional economy while including land use and hazard data;3) Cutting-edge ways of integrating micro-simulation models with traditional macro models to synergize the two approaches for developing new theory- and data-grounded macro damage assessments.SCALAR will drive a major breakthrough in integrating behavioral aspects of human decision-making into macro climate policy models. It will enable the quantitative exploration of cross-scale damage cascades, the identification of thresholds over which autonomous adaptation impacts the ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Seismic performance of light-gauge steel framed houses' in the context of a Sixth Framework call.

assistant: **Objectives**

The use of light-gauge steel houses is becoming more and more widespread in Europe, even if compared to the market share figures in the United States, Australia or Japan this branch of the industry is still in the initial development phase.Structural solutions are being offered as standard package by companies mainly in Great Britain and the Northern countries, while in other parts of Europe the use of steel framed houses is still at the level of 'experimentation'.This state is also conserved by the lack of design guidelines for such type of structures. This situation often leads to design mistakes ranging from improper detailing of certain parts to the gross misevaluation of the structural performance of the structure.Fortunately, under vertical loading the design principles of the thin-walled steel profiles is well established and codified, and vertical loading usually does not create problems. However, as the producing companies move from their local markets towards a more global approach, trying to expand their business to European level, another problem arises.Many European countries are seismically active regions, the highest risk of earthquake occurrence being present in Italy, Greece, Spain and Portugal. Romania, Slovenia, Bulgaria and other countries from southeastern Europe, candidates to join the Community are also earthquake prone regions.People sense earthquakes as 'remote' danger not usually present in their everyday life, until earthquakes eventually occur with devastating consequences both in terms of human life and economical loss.The aim of the research is to provide guidelines for the design of light gauge steel structures (houses, small office buildings, schools etc.) against earthquake loading. he result of the project can be the drafting of the fir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'FUture prospects on TRansport evolution and innovation challenges for the competitiveness of Europe' (FUTRE).

assistant: **Innovation**

The project will highlight which future challenges and demand drivers can have a considerable impact on the global demand patterns in the passenger and the freight transport and how this might affect the competitiveness of related industries and service providers. In doing so, it aims at bridging the gap between the manifold studies on the future of the European transport system and its subsections on the one hand, and, on the other hand, the issue of competitiveness that needs to be supported by targeted research strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Smart Manufacturing Advanced Research Training for Industry 4.0'.

assistant: **Innovation**

SMART 4.0 is a Fellowship Programme aimed at providing world-class training and research opportunities to 16 post-doctoral fellows in the area of Smart Manufacturing. SMART 4.0, a training, mobility and career development programme, will offer fellowships for incoming mobility of Experienced Researchers. The 24-month training programme will include a project from the fundamental and/or applied research fields of smart manufacturing, a compulsory 3-month secondment at an industry partner (19 placements already pledged), a spring and international summer school, and training in a series of scientific and transferable skills. The training focuses on delivering the next generation Smart Manufacturing leaders with strong “systems-level thinking” interdisciplinary skills to help drive Industry 4.0 forward for Europe. The role of industry is paramount throughout the programme design and implementation due to its critical importance to Europe’s economy. Furthermore, SMART 4.0 is committed to tackle gender inequalities, paying specific attention to attracting and supporting female researchers within smart manufacturing. SMART will publish 2 calls for proposals to attract the very best researchers. Researchers are invited to submit proposals, using an individually-driven, bottom-up approach. The evaluation and selection process will follow the principles of the Charter & Code and will be open, transparent, merit-based and equitable. It will include a remote peer review phase and an interview phase. SMART 4.0 will be implemented by Confirm, a dedicated Smart Manufacturing Research Centre, which brings together 8 Irish universities and a large group of industry partners and international collaborators, constituting an excellent dedicated training environment for the fellows. SMART