RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The physical basis of cellular mechanochemical control circuits' in the context of a Seventh Framework call.

assistant: **Objectives**

Biological cells possess a chemical “sense of smell” and a physical “sense of touch”. Structure, dynamics, development, differentiation and even apoptosis of cells are guided by physical stimuli feeding into a regulatory network integrating biochemical and mechanical signals. Cells are equipped with both, force-generating structures, and stress sensors including force-sensitive structural proteins or mechanosensitive ion channels. Pathways from force sensing to structural and transcriptional controls are not yet understood.The goal of the proposed interdisciplinary project is to quantitatively establish such pathways, connecting the statistical physics and the mechanics to the biochemistry. We will measure and model the complex non-equilibrium mechanical structures in cells, and we will study how external and cell-generated forces activate sensory processes that (i) act (back) on the morphology of the cell structures, and (ii) lead to cell-fate decisions, such as differentiation. The most prominent stress-bearing and -generating structures in cells are actin/myosin based, and the most prominent mechanoactive and -sensitive cell types are fibroblasts in connective tissue and myocytes in muscle. We will first focus on actin/myosin bundles in fibroblasts and in sarcomeres in developing heart muscle cells. We will observe cells under the influence of exactly controlled external stresses. Forces on suspended single cells or cell clusters will be exerted by laser trapping and sensitively detected by laser interferometry. We furthermore will monitor mechanically triggered transcriptional regulation by detecting mRNA in the nucleus of mouse stem cells differentiating to cardiomyocytes. We will develop fluorescent mRNA sensors that can be imaged in cells, based on near-IR fluore
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Humanizing Antiquity: Biocultural Approaches to Identity Formation in Ancient Boeotia, central Greece'.

assistant: **Innovation**

HumAn aims at providing insights into the biological dimensions of the sociopolitically constructed notions of kinship, citizenship and ethnicity in Archaic to Roman-era Boeotia (central Greece) by integrating mortuary data, historical information and osteoarchaeological analysis. Although identity negotiation is a social phenomenon, it has often constrained genetic relationships. Osteoarchaeological analysis can provide invaluable information on the extent of intermarriage and social mobility that accompanied belonging to specific groups. Ancient Boeotia is an ideal case study for the study of conflicting identities since it is characterized by the parallel evolution of the Boeotian League (the first Greek federal state) and a strong citizenship identity among Boeotian cities. The proposed project will explore genetic kinship and social structure in ancient Boeotian cities to assess whether belonging to specific groups hindered gene flow and social mobility. Written sources (historiography, drama, epigraphy), material culture (funerary data) and osteological analysis (macroscopic and microanalytical methods for the assessment of genetic relatedness, diet, activity, and health) will be amalgamated in achieving the aforementioned objective. The Department of Archaeology, University of Sheffield, forms the ideal environment for this project given its tradition in funerary archaeology and the study of identity and social structure in past societies, as well as the ample training opportunities it will offer to the candidate. The exploration of identity negotiation in ancient Greece can play a major role in increasing public awareness regarding the antiquity of social diversity. Finally, HumAn will greatly enhance the applicant’s scientific profile by allowing her to assume
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Quantum System-on-Chip based on silicon carbide'.

assistant: **Innovation**

A key question for modern quantum technology is: can isolated demonstrator experiments be united to implement real-world applications?Theory shows that by connecting quantum memories and processors, e.g., on a chip, surprisingly small systems can immediately achieve a quantum advantage. But the experimental implementation remains a grand challenge.Today, optically active spins in solids (colour centres) already implement quantum communication, computing, and memories – albeit individually. Pioneering efforts (including mine) focused on nitrogen-vacancy centres in diamond, but low material availability and difficulties in diamond fabrication hinder quantum chip developments.This project will realise a Quantum System-on-Chip with colour centres in an industrial semiconductor material: silicon carbide. Like a classical System-on-Chip, it will integrate separated processing and memory units, which are connected via photonic quantum communication lines. My mission goals are a) Entangling a quantum processor with a quantum memory; and b) Quantum processing based on instructions from the memory.To achieve these ambitious goals, I capitalise on two recent breakthroughs, which I spearheaded. My team developed the first quantum-grade fabrication of silicon carbide – and successfully integrated colour centres into nanophotonic quantum communication lines. Further, we recently investigated a new colour centre (the stacking-fault divacancy), which is the semiconductor twin of the nitrogen-vacancy in diamond. The similarity permits us to build upon established techniques and will ultimately allow demonstrating the long-proposed increased coherence times of nuclear spin qubits in silicon carbide.The successful project will initiate a transformative change towards reliable, cost-effect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Researchers in chemistry supporting economy and society', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The project concept is based on results of previous public opinion surveys, and the wish of people Researchers Night to become a regular event in their city, where they can interact with researchers and entertain. The main goal is to enhance public recognition of researchers and their role in society and economy, to encourage young people in Bulgaria to embark on scientific career.Main objectives:-disclose talents and hidden sides of life and work of researchers, and change existing stereotypes about researchers and their profession-raise awareness on the central role of researchers and their contributions to economy and society-highlight EU emphasis on researchers and opportunities for them in the large European labour market-make science and research career attractive for young people, and especially womenThe target audience will be, first, young people – children, teen-agers, students, and second, their parents and the public at large, including industrial and non-governmental organisations. The activities will take place in largest Bulgarian cities – Sofia, Varna, Plovdiv, Rousse, Burgas and Stara Zagora, where researchers will meet people in universities, Cabinets of Curiosity,  scientific cafés, Knowledge Transfer Kiosks, Innovation Fair, amuse them with verses, music life performances, experiments. European corner will inform about Marie Curie, Ernest Rutherford, EURAXESS, activities of FP7 People programme, success stories.The Communications strategy will convey two important messages: ‘European Researchers discover the micro world’ and ‘Research is a passion for a whole life’. It will also look for synergy with the International Year of Chemistry, 100 anniversary of Nobel prize of Maria Curie and creation of atom model by Ruddurford, and contributions of women
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The evolution of simplicity: comparative morphology, embryology and genomics of Xenacoelomorpha, the fourth phylum of deuterostome' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Understanding the origins and evolution of the highly diverse body plans of the ~30 distinct phlya that make up the animal Kingdom is a major programme in biology.  Recent research in my lab has demonstrated the existence of a new phylum of animals with a unique bodyplan - the Xenacoelomorpha - whose evolutionary origins are particularly surprising and highly contentious.Our work has elevated these very simple worms from a lowly position at the base of the animal tree to a place right within a group of highly complex animals called the deuterostomes.  The deuterostome ‘super-phylum’ includes three other major animal body architectures: the phyla Chordata (including Humans),  Echinodermata (starfish and sea urchins) and Hemichordata (acorn worms).All species within the phylum Xenacoelomorpha appear to have lost almost all features that define them as deuterostomes implying a history of extreme evolutionary simplification and loss.   The research I propose aims to understand the extraordinary evolutionary path that led to this bizarre phylum of worms and give deep new insights into the origins of phyla.We will use diverse techniques to study the morphology, ultrastructure, embryogenesis and developmental genetics of the Xenacoelomorpha to get a much clearer picture of the extent to which their phenotype is simplified.In parallel we will undertake ab initio sequencing of  the genomes of three species of xenacoelomorphs and perform comparative genomics across all deuterostome phyla to discover the genotypic correlates of their phenotypic innovations.In a reversal of the standard evolutionary approach which moves from morphology to genetics, we will use our genomes to discover the genetic novelties associated with all groups of deuterostome and then use data on gene function
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Open Research Biopharmaceutical Internships Support' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The current process of drug development is lengthy and inefficient. Only 1 out of approximately 10,000 drug molecules enters the market. Therefore more effective medicines, demanded by society, cannot be provided by pharmaceutical industry. To fill this gap, Open Research Biopharmaceutical Internships Support (ORBIS) proposes that the high attrition rate of new drug candidates might be reduced by over 20% by improving early stage R&D productivity. The overarching objective of ORBIS is therefore to form an international and inter-sectoral academic and industrial network. The action is aimed at improving the preclinical pathway of medicine development concentrating on processes and technologies.  The goal is to integrate multidisciplinary research by involving academia and industry from EU (Poland, Ireland, Finland, Germany and Czech Republic), EU associated country (Ukraine) and US to address the poor drug bioavailability as 70% of actives have solubility and/or membrane permeability problems. The action is addressed at selected molecules of class II and IV of Biopharmaceutics Classification System, to improve their pharmaceutical potential. The complementary consortium comprises experts in computations, physical chemistry, material science, nanotechnology, pharmacy, pharmacology and bioanalysis. The secondments will create a stimulating environment for early stage researchers to advance their individual career and soft skills. EU scientists will amalgamate their expertise in drug synthesis and dissolution, oral formulations, and bioanalytical methods with the knowledge on dermal research provided by the US partner. ORBIS will consolidate the existing links, promote long-term cooperation and exchange of knowledge between beneficiaries and partners. ORBIS will also enhanc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'RNA structure ensemble dynamics in living cells' to be submitted under Horizon Europe.

assistant: **Abstract**

Ribonucleic acid (RNA) is a Ribonucleic acid (RNA) is a jack-of-all-trades. It orchestrates and contributes to a multitude of essential cellular processes, both under physiological and pathological conditions. Among these, transcriptional and post-transcriptional regulation of gene expression, splicing, and translation control.Many of the functions of RNA rely on its ability to fold into stable secondary structures. However, RNA structures are far from being static. Indeed, for a given RNA, multiple alternative structural conformations can coexist as part of a heterogeneous and dynamic ensemble. Crucial to the regulatory functions of RNA structures is their ability to dynamically redistribute the relative abundance of specific conformations within the ensemble, in response to environmental cues. Despite its ascertained importance, the study of RNA structural dynamics in living cells has largely remained elusive.The goal of this ambitious proposal is to provide a deeper understanding of the mechanistic aspects underlying RNA structural dynamics in living cells, and thereby to comprehend the regulation and mechanism of action of RNAs. In other words: how are changes in the structure of an RNA triggered, and how do these changes reflect on the cell’s phenotype? By combining cutting-edge experimental and computational methods, many of which developed in my lab, my team will: (i) explore how RNA secondary structure ensembles dynamically change in response to environmental cues; (ii) investigate how RNA post-transcriptional modifications and editing contribute to and control RNA secondary structure ensemble dynamics; (iii) characterize RNA secondary structure ensemble dynamics at transcription, and their contribution to splicing regulation.By dissecting the role of RNA second
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Anti-microbial, self-cleaning copper composite coatings applied in metallic objects against infections transmission' under Seventh Framework.

assistant: **Concept**

Infection prevention measures aim to ensure the protection of people who might be vulnerable to acquiring an infection both in the general community and while receiving care due to health problems. The basic principle of infection prevention and control is hygiene. Hygiene could be divided in personal hygiene (e.g. hand washing) and inanimate object disinfection (e.g. use of chemicals for cleaning and sanitizing). However, hygiene practices is not enough to fight against infections. Indeed, the  estimated annual cost of medical care for treating infectious diseases in Europe is about €120 billion while HealthCare Acquired Infections are directly responsible for approximately 37,000 deaths annually and contribute to a further 110,000 across the EU. This is because, every person comes in contact several times per day with bacteria via touching inanimate objects such as handrails, shopping carts, door knobs etc and thus, the hazard of infections is more than evident. In order to overcome this important social problem, the SMEs participants propose a novel solution to be used against diseases transmission: The application of new copper based coatings in metallic objects with photo-catalytic imposed anti-microbial and self cleaning activity. These new composite coatings will consist of a copper matrix and chemically modified TiO2 nano-particles as reinforcing mean, and will present enhanced photo-catalytic activity under visible light irradiation. They will be applied in various metallic objects  such as handles, door knobs or rails, which can potentially be reservoirs of communicable viruses, and thus will lead to a decrease of the risk of getting infected by a factor of >50%.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'To explore the use of innovative biostatistical analysis in the identification of novel disease-genes', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

HiberGen mission is to identify 'disease-genes'. HiberGen's core competency is in the identification of gene mutations or SNPs, using a proprietary mutation detection platform technology, called SNaPIT. HiberGen has secured broad access to selected patient groups within the genetically homogenous Irish population. The application of HiberGen's SNaPIT to these patient samples will generate new genetic data. This data will require intense bio statistical analysis to identify disease linkage. And represents a core activity for HiberGen. With this Exploraty award, Hibergen will be facilitated to identify partners, with whom it can test such bio statistical systems. 'Disease-genes' represent significant value within the pharmaceutical industry as they represent new targets for the development of better diagnostic tools and improved therapeutic agents for the treatment, management and prevention of disease contributing to the community goals on many levels.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'RESILIENCE Preparatory Phase Project' in the context of a Horizon Europe call.

assistant: **Objectives**

RESILIENCE (Religious Studies Infrastructure: tooLs, Innovation, Experts, conNections and Centres in Europe) is a distributed Research Infrastructure that entered the ESFRI Roadmap in 2021. Its mission is to address the challenge of creating a larger, structured involvement of excellent scholars who innovatively produce competencies, knowledge, approaches, and impact within the scientific domain of Religious Studies.The main objective of the RESILIENCE Preparatory Phase Project (PPP) proposal is to bring the RI to the completion of its Preparatory Phase, which started in 2021 and will end in 2025. The work includes legal, governance, financial, technical, strategic, and administrative aspects carried out in 6 work packages.The primary outcomes of the PPP are the setting-up of the legal and financial frameworks of the functioning of the RI; the preparation of signature-ready documents towards the implementation phase; the completion of the RESILIENCE service catalogue, and the establishment of legal agreements and technical frameworks for their operation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Treatment of craneofacial syndromes with biodegradable plates, screws and wire' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Craniofacial syndromes represent a group of rare and very rare diseases with prevalence of 9 to 16 births per million. At present surgically corrected cranial bones are fixed in a new position by using metallic plates, screws and wire.The present project introduces new technology for the fixation of corrected cranial bones: 1) in children with rapidly biodegrading fixation materials and 2) in adults with slower biodegrading fixation materials. A European dimension is required to obtain reliable information as regards this treatment. Because of the limited number of craniofacial syndromes, information from different centres has to be pooled. A project of this size can only be carried out at a European level. No single country could expect to have experts in all the fields involved. The project will benefit from the long-standing European expertise in the development of biodegradable materials for surgical use. Of particular importance are the patents regarding increasing the strength of bioabsorbable materials many-fold, by partner Tampere. Great financial advantage is gained by avoiding a second operation for removal of osteosynthesis material. This will reduce the cost of treatment by about 25%. The use of biodegradable screws diminishes the risk of brain damage. Biodegradable matenals can be used in the skulls of small infants.There is a strong need for biodegradable osteofixation materials (plates, screws and wires) in craniofacial surgery. These are eliminated via the normal metabolism of the organism. Presently available metallic osteofixation devices have been found to migrate to the inside of the skull. There may be a danger of brain damage. Metallic plates and screws inhibit skull growth and interfere with neuroradiological investigations; they usually have to b