RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding malignant transformation of precancerous lesions in human colon' (Transformation), addressing dissemination and exploitation.

assistant: **Impact**

A crucial milestone in tumor progression is the transformation from a benign adenoma to a malignant cancer, which has profound impact on clinical outcome and therapy design. Despite its importance, it is poorly understood why it manifests itself as a bottleneck that can restrain precancerous adenomas for years. While recent sequencing efforts inform ‘static’ insights into the status of cancer genomes, these are incomplete to infer how they evolved, assess functional consequence of mutations, nor how much malignancy is environmentally instructed.Practical limitations hamper scientific advancement into the dynamic nature of tumor evolution. Foremost, studying human tumor evolution is challenging as sequential sampling is not feasible, and pre-malignant events that may hold the clue for understanding transformation often occur years before cancer diagnosis. Moreover, experimental models that reflect malignant transformation, let alone of human origin, are lacking.TRANSFORMATION aims to resolve how human cancer genomes evolve towards malignancy, and its role in triggering malignancy.To gain new insights on this matter, TRANSFORMATION takes a unique approach to produce experimental insights into evolutionary parameters that are inherently dynamic in nature and cannot be obtained from tumor sequencing alone. Using paired biopsies from early-stage colon cancers, I generated unique organoid models from pre- and post-transformation regions. Together with in situ analysis of matched tumors, TRANSFORMATION will reveal the elusive rate and order by which mutations and copy-number alterations are acquired, the patterns by which cancer karyotypes evolve, dissecting functional from non-functional genetic heterogeneity on tumor phenotypes and investigate possible selection pressures im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sample power electronic module construction for testing, characterisation and manufacturability assessment""' (PEMREL) targeting Seventh Framework.

assistant: **Abstract**

Power Module Reliability (PEMREL) addresses the clean sky’s call “Sample PEM (Power Electronic Module) construction for testing, characterisation and manufacturability assessment. This proposal aims to compliment other research into the development of an all SiC 10kW inverter, implemented in a double-side cooled, non-hermetic sandwich packaging technology (no bondwires), able to withstand a nominal ambient temperature range of -60°C to +200°C.Key developments will include FMMEA, and the development of physics-of-failure reliability models for both type 1 & 2 modules. These modules will be tested for electrical and thermal chracterisation. Power and passive cycling of the modules will be undertaken to generate reliability data for validating the developed reliability models.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'NOVEL EFFICIENT CATALYSTS FOR BIO-SYNGAS CONVERSION TO C2-C4 ALCOHOLS'.

assistant: **Innovation**

Bioethanol is currently produced primarily by fermentation of sugars, an expensive and energy intensive process. Gasification of biomass to synthesis gas (H2/CO), followed by catalytic conversion of syngas, could produce significant amounts of fuel grade C2-C4 alcohols that can be blended in gasoline. However, the catalytic conversion of syngas to higher alcohols still remains challenging and no commercial process exists today. R&D achievements necessary to make this process viable include the development of improved active and selective C2-C4 alcohol synthesis catalysts operating at mild conditions, the elucidation of the reaction mechanism and kinetics via advanced mechanistic and micro kinetic studies and the exploration of different engineering routes and advanced reactor configuration concepts. The main objective of the proposed project is to design a novel generic catalyst for the hydrogenation of CO to C2-C4 alcohols, operating at moderate pressures, using syngas from biomass gasification as feedstock. This technical goal is proposed to be achieved by closely linking material synthesis with advanced surface characterization to identify the nature of the active sites and kinetic and mechanistic characterization of the reaction routes. The environmental impact of the envisaged developed catalytic process will be analyzed via Life Cycle Analysis (LCA) and benchmarked against emerging technologies for 2nd generation cellulosic ethanol production. The execution of this project by the applicant will aid in her re-integration in the host organization, CERTH, and will lead to new know-how and technology based on the skills acquired by the applicant during her previous MC mobilization period. The project will enhance the skills and experience of the research fellow, contr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Software quality and requirements'.

assistant: **Objectives**

This trial application in software technologies aims at early experimentation of a new approach to software requirements. The main objective of the project is the management of customers expectations throughout the project (initial expectations and changes).Two methods will be experimented on software developments:- The method designed by professor Shiba (M.I.T and University of Tsukuba, Japan) named Design to Market" and focused on requirements capture and management.- The well-known QFD method. (Quality Function Deployment) designed to monitor requirements satisfaction throughout the life cycle of a product.These two methods have already shown to be very valuable for the development of complex products and need to be adapted to the peculiarity of software development.The project will be carried out in three main steps:- Adaptation of the existing methods to software and definition of a common method framework.- Experimentation on real projects.- Exploitation and dissemination of results.The real projects selected for the experimentation of the method are the following:- Development of an airport information system, managed by the French Civil Aviation Direction.- Development of an information kiosk for banking products and services, managed by the Xios Bank in Greece.- Development of a Museum Information System (MOSAIC), managed by the National Museums of Scotland (NMS). Currently this is the largest museum-related multimedia project aimed at both visitors and televisitors.All three projects need a tight co-operation between users and developers for the production of requirements. The fact that they belong to different sectors is expected to provide very valuable input to the deployment of the method.The project will also benefit from the active participation of Europ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'STING immune activation and regulation by phosphatidylinositol 4-phosphate-associated components'.

assistant: **Objectives**

The immune response to cytosolic DNA is crucial for preventing tumour formation and virus infection. This response critically depends on the cGAS-STING pathway, which detects cytosolic self-DNA present in tumour cells and viral DNA. STING can also detect cytosolic self-DNA induced by upon RNA virus infections, and numerous RNA viruses have evolved strategies to disable STING.STING activation is a complex process that requires various post-translational modifications, leading to STING trafficking and activation at the Golgi apparatus. STING activation induces the transcription of genes that promote immune cell recruitment. Aberrant STING regulation may lead to virus infections, inflammatory disorders, and tumour formation. Many of the regulators involved in STING activation are unknown. To identify host factors regulating STING activity, I recently performed a genome-wide CRISPRi screen (Luteijn et al, 2019, Nature). I found many novel genes involved in STING activation, including the Golgi protein ACBD3. This protein localizes the phospholipid phosphatidylinositol 4-phosohate (PI4P) to the Golgi membrane by recruiting the PI4P kinase PI4KB. My preliminary work revealed that STING activation in the Golgi critically depends on ACBD3 and PI4P. Remarkably, ACBD3 and other PI4P-associated factors are also targeted during infection by certain RNA viruses. It is completely unknown how ACBD3 and PI4P distribution affect STING activity, and if PI4P hijacking by RNA viruses modifies the STING-induced immune response.This project has 3 main objectives:1.Define the role of ACBD3 and PI4KB expression and function on STING activation2.Identify and target regulators of PI4P biology to increase STING activity3.Define the role of PI4P hijacking by RNA viruses on STING immune evasion Und
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Excision Repair and chromatin interaction dynamics' to be submitted under Seventh Framework.

assistant: **Abstract**

DNA damage is a fact of life. Lesions hamper genome function, induce mutations causing cancer and trigger senescence or cell death contributing to aging. Therefore cells are equipped with a sophisticated defence machinery: DNA Damage Response (DDR) including different repair pathways. Nucleotide excision repair (NER) is versatile repair process, eliminating helix-distorting lesions, e.g. bulky adducts and sun-induced lesions. Very cytotoxic transcription-blocking lesions are removed by a dedicated sub-pathway, transcription-coupled (TC-)NER. The impact of NER is highlighted by 4 disorders: xeroderma pigmentosum (XP), Cockayne syndrome (CS), trichothiodystrophy and UV-sensitive syndrome (UVSS). XP patients are cancer-prone due to global-genome (GG-)NER defects, whereas CS patients, impaired in TC-NER, display progeroid features, which are thought to derive from endogenous oxidative DNA lesions hampering transcription. Consistent with this, CS cells are sensitive to oxidative agents, whereas TC-NER-deficient UVSS patients are not sensitive to oxidative agents and do not display aging features. This implies lesion-specific TC-NER, arguing for distinct operational TC-repair machineries. The relative importance of DDR pathways varies with the type of damage, cell type and stage of development determining onset of cancer and aging pathologies. The challenging ambition of this proposal is to gain in depth insight into the role of NER in protection against cancer and aging by an integral multi-disciplinary approach which includes new mouse models for novel TC-NER genes, live cell and tissue NER kinetic analyses, advanced proteomics and analysis of NER-related chromatin dynamics to dissect cross-talk with other pathways. The strength of this project is the comprehensive strategy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dissecting the molecular mechanisms that execute developmental programmed cell death in plants' (2014-2020).

assistant: **Concept**

Programmed Cell Death (PCD) is fundamental to the development and health of multicellular organisms. However, our knowledge on developmentally controlled PCD in plants remains fragmentary, despite its undoubted significance for plant growth and reproduction.My team has established the Arabidopsis root cap as a novel model system for developmental PCD in plants. This model has enabled us to identify a gene regulatory network controlling the preparation of PCD. However, the molecular processes that terminate the vital functions of a plant cell during the final steps of PCD execution remain unknown.Exploiting the accessibility of the root cap for live-cell analysis of PCD execution, we obtained preliminary data revealing an unexpected succession of distinct membrane permeabilization events in which the endoplasmic reticulum breaks up before the central vacuole. I hypothesize that this sequential de-compartmentalization is the mechanism underlying the irreversible and orderly execution of PCD.Recent advances in several key technologies provide unprecedented opportunities to test this hypothesis and make a quantum leap in our understanding of the mechanisms carrying out PCD execution.I will employ correlative super-resolution light and electron microscopy to analyse PCD execution in unparalleled spatial and temporal resolution. RNA sequencing of single cells at the onset of PCD execution will provide information on the genes that are required for this rapid process. Advanced proteomics techniques will provide a direct route to identify proteins acting on membrane permeabilization during PCD execution. Lastly, multiplex and tissue-specific mutagenesis via innovative CRISPR screens will enable me to overcome genetic redundancy and lethality in the PCD context. The detailed und
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '“Between the Times”: Embattled Temporalities and Political Imagination in Interwar Europe' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The proposed project offers a new, pan-European intellectual history of the political imagination in the interwar period that places the demise of historicism and progressivism – and the emerging anti-teleological visions of time – at the center of some of its most innovative ethical, political and methodological pursuits. It argues that only a distinctively cross-disciplinary and European narrative can capture the full ramifications and legacies of a fundamental rupture in thought conventionally, yet inadequately confined to the German cultural space and termed “anti-historicism”. It innovates narratively by exploring politically and theoretically interlaced reinventions of temporality across and between different disciplines (theology, jurisprudence, classical studies, literary theory, linguistics, sociology, philosophy), as well as other creative fields. It experiments methodologically by reconstructing the dynamics of political thought prosopographically, through intellectual groupings at the forefront of the scholarly and political debates of the period. It challenges the sufficiency of the standard focus in interwar intellectual history on one or two, at most three (usually “Western” European) national contexts by following out the interactions of these groupings in France, Britain, Germany, Russia, Czechoslovakia, and Romania – groupings whose members frequently moved across national contexts. What were the political languages encoded in the reinventions of time, and vice versa – how were political aims translated into and advanced through theoretical innovation? How did these differ in different national contexts, and why? What are the fragmented legacies of this rupture, disbursed in and through the philosophical, methodological and political dicta and dogmas t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innovative nondestructive testing and advanced composite repair of pipelines with volumetric surfaces defects' in the context of a Seventh Framework call.

assistant: **Objectives**

Pipeline systems have supreme significance for an effective functioning of industry providing Eastern and Western European markets with energy resources: crude oil, natural gas and liquid petroleum products. Taking into account long life of pipeline networks and situation, when over 20% of large-diameter pipelines are with an exhausted lifetime, an important task at the present time becomes an ensuring of reliability for these transport systems.An intensive study shows that among the main reasons of pipeline accidents are the volumetric surface defects (VSD) arising as a result of corrosion or erosion-corrosion processes and by this way considerably decreasing the pipeline strength. In order to ensure efficient and safe operation of existing pipelines, operating companies routinely inspect the pipes. The methods that are used for this purpose, like “smart pig”, are sufficiently expensive, require, in some cases, significant reconstruction and have an insufficient sensitivity. An application of new composite materials for the repair of damaged pipelines considerably improved situation in the last time. However numerous standards associated with this type of repair are based on simplified approaches and do not take into account the stress-strain state in the damaged areas.Strategic objective of the project is addressed to the improvement of infrastructure in EU and Third counties by the rising of reliability of existing pipeline systems. Work over this project will serve IRSES main goal achievement – strengthening research partnerships through short period staff exchanges and networking activities between organisations from EU and Third countries.The scientific and technical objectives are improvement of existing and developing of new methods for detection and repair of V
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Technology Options for Coupled Underground Coal Gasification and CO2 Capture and Storage' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The main objective of the proposed project is to develop a generic UCG-CCS site characterisation workflow, and the accompanying technologies, which would address the dilemma faced by the proponents of reactor zone CO2 storage, and offer technological solutions to source sink mismatch issues that are likely to be faced in many coalfields. This objective will be achieved through integrated research into the field based technology knowledge gaps, such as cavity progression and geomechanics, potential groundwater contamination and subsidence impacts, together with research into process engineering solutions in order to assess the role/impact of site specific factors (coal type, depth/pressure, thickness, roof and floor rock strata, hydrology) and selected reagents on the operability of a given CO2 emission mitigation option in a coalfield.CO2 storage capacity on site for European and international UCG resources will be assessed and CO2 mitigation technologies based on end use of produced synthetic gas will be evaluated. The technology options identified will be evaluated with respect to local and full chain Life Cycle environmental impacts and costs.The project takes a radical and holistic approach to coupled UCG-CCS, and thus the site selection criteria for the coupled process, considering different end-uses of the produced synthetic gas, covering other options beyond power generation, and will evaluate novel approaches to UCG reagent use in order to optimise the whole process. This approach aims at minimising the need for on-site CO2 storage capacity as well as maximising the economic yield of UCG through value added end products, as well as power generation, depending on the local coalfield and geological conditions.