RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Alteration of Mfn2 protein and Endoplasmic Reticulum to Mitochondria calciUm transfer in STress' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Stress conditions threaten the organism’s homeostasis triggering adaptative responses. One of them is the increased energy demand from the brain. When stress becomes chronic, it leads to behavioural changes that range from adaptation to psychopathology. aMUST project aims to understand the neurobiological mechanisms underlying stress response. Considering that nowadays chronic stress is a risk factor for psychopathologies, such as anxiety and depression, with 25% of incidence in the population and an economical burden of €170 billion/year in EU, the aMUST project is extremely relevant and timely. Mitochondria and bioenergetics are emerging as important key players in stress-related pathologies. Whereas the energy-related impact of stress has received considerable attention in the past few years, the critical importance of the specialized cellular hubs called mitochondrial-endoplasmic reticulum (ER) associated membranes (MAMs) in stress responses, remains to be elucidated. Combining cutting-edge approaches, the aMUST project will shed light on this crucial biological question. Accordingly, intracranial lenses insertion of the mini endoscope in stress-vulnerable brain regions will be used to allow the study of in vivo mitochondrial calcium dynamics during behavioral experiments. 3D electron microscopy, protein ligase assay and BioID in vivo proteomics will allow to determine composition in MAMs structures and which protein interactions are altered during stress. The use of transgenic animals, compounds that change MAMs proteins function and alleviate ER-stress will be used to prevent possible modifications that cause vulnerability to stress. Therefore, aMUST project outcomes will unveil the MAMs-related mechanisms needed to open new therapeutic avenues to promote resilien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Connected Electric Vehicle Optimized for Life, Value, Efficiency and Range' (CEVOLVER), addressing dissemination and exploitation.

assistant: **Impact**

The current generation of electric vehicles have made significant progress during the recent years, however they have still not achieved the user acceptance needed to support broader main-stream market uptake. These vehicles are generally still too expensive and limited in range to be used as the first car for a typical family. Long charging times and uncertainties in range prediction are common as further barriers to broader market success. For this reason the CEVOLVER project takes a user-centric approach to create battery-electric vehicles that are usable for comfortable long day trips whilst the installed battery is dimensioned for affordability. Furthermore the vehicles will be designed to take advantage of future improvements in the fast-charging infrastructure that many countries are now planning.  CEVOLVER tackles the challenge by making improvements in the vehicle itself to reduce energy consumption as well as maximizing the usage of connectivity for further optimization of both component and system design, as well as control and operating strategies. This will encompass measures that range from the on-board thermal management and vehicle energy management systems, to connectivity that supports range-prediction as a key element for eco-driving and eco-routing driver assistance. Within the project it will be demonstrated that long-trip are achievable even without further increases in battery size that would lead to higher cost. The driver is guided to fast-charging infrastructure along the route that ensures sufficient charging power is available along the route in order to complete the trip with only minimal additional time needed for the overall trip. The efficient transferability of the results to further vehicles is ensured by adopting a methodology that pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Real-Time high-content Super-Resolution Imaging of ES Cell States' (RT-SuperES), addressing dissemination and exploitation.

assistant: **Impact**

The development of super-resolution (SR) microscopy in recent years has revolutionized cell biology, breaking the diffraction limit of light microscopy by order of magnitude. However, SR is currently incompatible with high-content imaging. RT-SuperES will provide a groundbreaking and affordable technology with automated SR capabilities beyond the state-of-the-art. To this end, we will generate a library of endogenously-labelled SNAP-tag fusion proteins in mouse embryonic stem cells (ESCs), and deploy a real-time decision-making module, which will continuously monitor our SNAP-tagged cells using fast fluorescence imaging, and, once a change is detected, will fix the desired cells, and switch to SR mode. By bringing together seven world-leading experts from four different countries, combining basic and applied research and industry, we propose several firsts: a) The first endogenously-labelled clone library of SNAP-tag fusion proteins; b) Utilize machine learning (ML) for real-time automated decision making, autonomously switching from fast conventional to SR imaging; c) Combine high content with SR imaging; d) Integrate novel, cutting-edge technologies, namely SR Radial Fluctuations (SRRF), NanoJ-Fluidics, Single Molecule Localization Microscopy (SMLM) and Structured Illumination Microscopy (SIM); e) Collect large scale imaging datasets of cell states in ESCs, and f) Provide cell-cycle stage-dependent nanoscale localization of selected nuclear and chromatin proteins (e.g. H3.3), during early ESC differentiation. RT-SuperES will provide the scientific community with the first-of-its-kind commercial real-time SR-highcontent imaging system, and the first library of endogenously SNAP-tagged ESC clones, which are ideal, among many other things, for SR imaging.


**Keywords:**
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Hospital@Home: Person-centered Digital Transformation for Integrated Home Care' in the context of a Horizon Europe call.

assistant: **Objectives**

The Hospital@Home (H@H) project unites leading academic hospitals and industry in Europe to provide hospital-level care to patients right to their own homes. Designed around five major clinical areas – cardiovascular disease, pulmonary disease, minor stroke/TIA, migraine, and cluster headache – the H@H project is designed to improve clinical and patient-reported outcomes, enhance patient experience and reduce hospital burden to enable sustainable health systems across Europe. H@H’s powerful, interdisciplinary consortium consists of five leading European university hospitals, MedTech and Pharma partners, patient organizations, and health economics experts. Supported by a robust digital infrastructure, the project integrates wearable monitoring, AI-driven predictive analytics, patient-reported outcomes (PROMs/PREMs) and digital decision support into real-world care pathways. Patient and healthcare professional engagement, ethics, equity and system-level sustainability are structurally woven into every phase of the project’s three-phased methodology of Mapping, Testing, and Implementing. H@H directly addresses the goals of IHI Call 9 Topic 3 by overcoming real-world barriers to digital care integration while firmly placing people’s needs and preferences at the center of the care transformation. The trustworthy AI-supported H@H system will generate new evidence on patient-centered models by integrating PROMs, PREMs, and real-world data. H@H delivers scalable digital platforms and AI tools to improve efficiency, reduce costs, and enable sustainable business models. H@H will deliver actionable blueprints for Europe’s healthcare future - boosting patient outcomes while easing system burdens through high-quality, accessible home care.


**Keywords:** digital care integration; v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advanced techniques in isotopic biogeochemistry for the estimation of fossil mammal trophic position' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The principal objective of the IsoTroph project is to improve the geochemical method used in paleontology of terrestrial mammals, through the application of stable isotopes of single amino acids in paleoecology. In particular, the project focuses on a single amino acid (glutamate and phenylalanine) δ15N trophic discrimination factor (TDF). It is a quantitative parameter used in reconstructions of past animal or human trophic positions (a primary consumer – a herbivore; a secondary consumer – a carnivore feeding on herbivores; etc.), crucial for understanding the evolution of environments. The TDF has never been established before for terrestrial mammals, although it is a key parameter in modelling the past ecology.The main research method of IsoTroph is the analysis of δ15N in bone collagen of a population of a predator and that of its prey, and then calculating the TDF between these populations. To achieve this, the project will involve a study of modern populations (collections of recent bones of wolf, lynx, red fox, and their prey, from Białowieża Forest and fox den), as well as a collection of fossils from a Pleistocene carnivore den (cave hyena and its prey). These collections will provide insight into four species of mammalian carnivores, representing variable ecology (both hypercarnivores and omnivores), and different chronology (recent and Pleistocene).The project offers a great chance for professional training in a new method with a vast potential to be used in paleoecology – the stable isotope composition of single amino acids. This training is to be performed through research, which will bring the high quality results of the greatest interest for a wide audience of scientists currently involved in paleoecological studies of animals and humans. The project wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The next-generation heart pump to change patients’ lives and create a new standard of care' in the context of a Horizon 2020 call.

assistant: **Objectives**

Advanced heart failure (HF) is a deadly disease, with a booming incidence driven by durable socio-demographic trends. Left ventricular assist devices (LVADs) are a life-saving therapy for advanced HF patients and represent a billion-euro market. However, only 13% of the 60,000 eligible patients are implanted with current LVADs each year, due to the extremely high rate of severe adverse events (stroke, bleeding, infection) and the limited quality of life.CorWave is an innovative French SME created in 2011 with a mission to create a new standard of care for advanced HF patients. The company is developing a game-changing LVAD, which relies on a unique and patented breakthrough technology, the wave membrane. Unlike all current devices, which are continuous-flow rotary pumps, CorWave LVAD is a smart pump producing a physiologic and pulsatile blood flow, to restore a normal life to patients with minimal side effects. CorWave LVAD will cut in half severe complications and rehospitalisation costs. CorWave projects to take over 60% of the market and reach up to €1.1 billion of turnover in 2030, by taking advantage of the LVAD market structure, which is very favourable to new entrants (concentrated on a few centres), and by increasing the penetration rate.We have built a team of 50 experienced people, including world-class experts, and have gained a strong market traction. The clinical centres who support us through letters of intent are worth >25% of the European market. We partner with a network of industrial suppliers and have our own pilot production unit to manufacture prototypes that have proved successful in preclinical studies.Thanks to EIC Accelerator, CorWave will transform a very promising preclinical prototype (TRL 6-7) into an industrial CE-marked medical device (TRL
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Optimization of Water-Gas-Shift catalysts: a fundamental and mechanistic approach' in the context of a Seventh Framework call.

assistant: **Objectives**

The water gas shift (WGS) reaction is a critical process in purifying hydrogen for fuel cells. As the employment of hydrogen as energy carrier is improving worldwide, the use of cost-effective low temperature WGS catalysts is required. The rational design and optimization of catalysts needs the understanding of catalyst structure and function under reaction conditions. The project will focus on the study of metal/CeO2 and metal/TiO2 systems. In-situ studies to determine the structure and oxidation state of high surface area catalysts under reaction conditions will be coupled with mechanistic studies on well-defined model systems. Computational modelling of chemisorption of reactants, stability of intermediates and activation barriers will help to get a better picture of reaction mechanism. The acquired knowledge will be employed for a rational design and preparation of an advanced generation of highly active catalysts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Coming-of-age of Process Research: Connecting Theory with Measurement and Modelling', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Recent innovations in measurement such as ambulatory assessments and experience sampling, have created the unique opportunity to study psychological processes as they unfold over time in everyday life. Combined with novel statistical models that focus on within-person dynamics, these developments offer a radically new perspective on foundational concepts in psychology. In clinical psychology for instance, these innovations are used to study mental disorders as networks of symptoms that trigger each other over time, and this is leading to valuable new insights on the emergence and persistence of psychopathology. How to optimally employ these new tools is a major methodological challenge, however: Researchers must determine whether to use self-reports or physiological measures, what the frequency and duration of the measures should be, and which model fits their data and allows to test their theory. The costs of choosing inapt measurement and modelling methods can be severe and include: invalid results, erroneous conclusions, poor theory building, wasting resources, diminished trust in psychological science, and outcomes that are less useful or even harmful for individuals and society.The aim of OPTIMAL is to resolve this challenge by developing an overarching methodological framework of process research that allows psychological researchers to connect theory, measurement and modelling. To achieve this, I will: a) strengthen the pairwise links between theory, measurement and modelling; b) conduct literature inventories in five substantive areas to elicit information on how to measure and model particular processes; and c) develop a taxonomy of models and an interactive website that researchers can use to guide them to optimal models. The generic nature of this methodologi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The genomic architecture of speciation in tropical butterflies' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

These are exciting times for speciation research with a wealth of recent theoretical and empirical advances, but there is much we still do not understand. The Heliconius butterflies offer an excellent opportunity to gain novel insights into the genetic architecture of speciation and its genomic consequences, by integrating genomic data with the well-studied ecological and behavioural processes that underlie speciation in this group. Here I will bring together two lines of recent research in speciation, a) the evolution of genetic architectures, such as clustering of barrier genes, that facilitate divergence in the face of gene flow and b) the genomic patterns of divergence. First, I will apply large-scale whole genome resequencing to study divergence and gene flow between species, and test whether speciation proceeds through divergence of gradually expanding genomic islands under divergent selection. I will also develop novel theory to interpret these patterns. Second, I will test whether loci controlling behavioural and ecological traits that cause reproductive isolation are clustered in the genome, using a genome-wide quantitative trait analysis of reproductive isolation in two hybridizing species pairs. Third, I will investigate the role of chromosomal rearrangements in reducing between-species recombination rate where species hybridize, and directly study their influence on recombination rate. Overall, the project will integrate information on the distribution of genes controlling ecological, behavioural and genetic differences between species with patterns of recombination, in order to understand the process of genome divergence and adaptive radiation. This work will offer new insights into speciation, a process fundamental to evolution and biodiversity, but also h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular basis of cell-to-cell communication in the cardiovascular system : Structure, Function and Distribution of Gap Junctions and their Constituent Channels under Normal and Abnormal Conditions' (1994-1998).

assistant: **Innovation**

Four studies will be carried out:1. Distribution of connexins in the cardiovascular system under normal and pathological conditions.2. Conductance and permeability of individual gap junction channels.3. Regulation of gap junctional conductance and permeability in cardiovascular tissue under normal and abnormal conditions.4. Function of connexins in developing and adult cardiovascular tissues.Cell-to-cell communication via arrays of intercellular channels connecting the interior of neighbouring cells called gap junctions, is involved in several physiological processes in the cardiovascular system. Examples are electrical impulse conduction in heart and control of cell proliferation in vascular system. Pathological changes in these processes may lead to potentially life-threatening diseases of the cardiovascular system like cardiac arrhythmia leading to ventricular fibrillation or intimal hyperplasia and atherosclerosis leading to myocardial infarction or cerebral stroke.Gap junction channels consist of 12 protein molecules belonging to the family of connexins, arranged in two hexameric hemichannels (connexons) in each of the apposed cell membranes. The electrical conductance and diffusional permeability of the channels is strongly dependent on the particular connexin they are built of. In cardiovascular system at least 6 different connexins (Cx37, 40, 43, 45. 46 and 50) have been detected. Gap junction channel properties are modulated by changes in intracellular ion composition and through the activity of hormones or vasoactive substances, which, via signal transduction pathways lead to connexin phosphorylation / dephosphorylation cycles. Information about the distribution, function and modulation of gap junction channels built from the various connexins is accumulating