RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Engineered multi-well platforms integrating biochemical and biophysical cues for the functional maturation and electrophysiological monitoring of cardiac tissue models.' (EMPATIC) under Horizon Europe.

assistant: **Objectives**

Cardiovascular diseases are the major cause of mortality worldwide, making the demand for new therapies an urgent need. Additionally, unexpected cardiac adverse effects are the leading causes of discontinuation of clinical trials and withdrawal of drugs from the market. Such issues could be addressed by relevant in vitro human cardiac tissue models reproducing in vivo-like pharmacological response. However, most in vitro cardiac tissue models developed so far have been limited by complex design to enhance cardiomyocyte maturation, and poor ability to provide real-time functional assessment, making them poorly robust, reproducible, scalable and user-friendly. In EMPATIC I will overcome such limitations, through synergistic exploitation of biochemical and biophysical stimuli for cardiomyocyte phenotype maturation, studied in ERC project BIORECAR (772168). EMPATIC will provide a novel user-friendly and versatile multi-well plate platform for the in vitro modeling of mature functional human cardiac tissues and the non-invasive label-free monitoring of electrophysiological properties. EMPATIC platform will combine: (i) tailor-designed multi-well components, imparting biochemical and biophysical cues to in vitro cultured cells, and (ii) bioelectronic components enabling controlled electrical stimulation (ES) and biosensing. Collaboration with major experts in bioelectronics, cardiac regenerative medicine and electrophysiology, and companies will support EMPATIC innovation. My previous experience as coordinator of basic and applied research projects and co-founder of academic spin-off companies, and the entrepreneurship experience of 50% of EMPATIC team will support the process of technology development and validation.


**Keywords:** cardiac tissue models, in vitro testing, m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Genetic and epigenetic consequences of hybridization and polyploidy in Dactylorhiza (Orchidaceae)' (Orchidaceae).

assistant: **Concept**

Hybridization and polyploidization are now recognized as major phenomena in the evolution of plants, promoting genetic diversity, adaptive radiation and speciation. New findings suggest that the interactions of the combined genomes in allopolyploids induce waves of genetic and epigenetic alterations that have the potential to result in novel expression patterns and new phenotypes.Such novelties, in combination with heterosis and gene redundancy, might confer on hybrids an elevated evolutionary potential. Hybridization has the potential to occur repeatedly between different populations of the same parental taxa, leading to arrays of allopolyploids that subsequently interbreed.This is the case also in the Dactylorhiza incarnata/maculata complex, e.g., for the allotetraploid pair D. traunsteineri and D. majalis s.s., which both resulted from hybridization of D. fuchsii and D. incarnata.To further our understanding on the consequences of hybridization and genome duplication on polyploid genome natural evolution and adaptation to the environment, I propose here the use of this allotetraploid pair with similar genetic background, but difference in their evolutionary history and ecology: D. traunsteineri is a recently formed, morphologically variable hybrid with a narrower distribution and D. majalis s.s. has a wider distribution and is much more uniform morphologically.A cDNA amplified fragment length polymorphism (AFLP) genome-wide survey of the transcriptome, together with a methylation sensitive AFLP approach is expected to indicate the functional relevance of correlations between gene expression and the development of a phenotype, the direction and stochastic nature of the diploidization process, and the molecular mechanisms that result in adaptation to different habitats
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Past, present and future Exchanges of CArbon and Water between the vegetation and the atmosphere: new insights from analysis and modelling of stable carbon ISOtope data', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Water-use efficiency (WUE, the carbon gained through photosynthesis per unit of water lost through transpiration) is a tracer of the plant physiological controls on the exchange of water and carbon dioxide between terrestrial ecosystems and the atmosphere. Rising CO2 concentrations and climate change both affect the stomatal regulation of leaf gas exchange and must influence WUE. However, the magnitude of change in plant WUE estimated by different methods differs strongly amongst studies, indicating unresolved issues. Moreover, current land surface models produce inconsistent and often unrealistic magnitudes and patterns of variability in WUE. This project thus aims at developing the use of carbon isotopes (13C) in terrestrial biosphere modelling to better understand and predict terrestrial carbon and water cycling and to evaluate their representation in models. We will perform a detailed investigation of the influences on discrimination against 13C during photosynthesis and their representation on various scales in the Joint UK Land Environment Simulator (JULES) model, which forms the land component of the UK Earth System Model, and implement the resulting discrimination model in JULES. We will then evaluate historical simulations of past changes in WUE and quantify the relative contributions of each forcing (climate and CO2) on WUE trends. Finally, we will perform projections of future changes in WUE following the 1.5°C and 2°C targets in global average temperature rise by 2100 proposed by the United Nations Framework Convention on Climate Change (UNFCCC). This project will contribute to the establishment of an improved theoretical and empirical basis for next-generation land surface modelling, and will address key uncertainties including the magnitude of changes in c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Internal target experiments with highly energetic stored and cooled secondary beams at the international accelerator facility, Darmstadt Ion Research and Antiproton Center (DIRAC)' (DIRAC) under Sixth Framework.

assistant: **Objectives**

The present proposal aims at the design and development of one of the key aspects of the International Accelerator Facility for Beams of Ions and Antiprotons (www.gsi.de/GSI-Future/cdr), planned by the European and international science community for con struction at the GSI Laboratory in Darmstadt, Germany: the broad implementation and optimisation of ion storage/cooler rings and of in-ring experimentation with internal targets and secondary beams.This will provide the European community with worldwide un ique accelerator capabilities. It will allow the broad, and in many respects novel use of stored, cooled ion beams including antiprotons with superior beam phase space. It will open new frontiers in several areas of research. Internal target experiments in cooler/storage rings require the delicate interplay between accelerator operation and experiment and a correspondingly wide range of expertise. This is particularly true for the multiple and highly parallel use envisioned for the present facility. This is reflected in the broad spectrum of participants involved in the proposal. It indicates a truly collaborative approach from the European science community. It promises substantial added value through the worldwide unique facility characteristics, and thus potential for European scientific leadership.The concept of the facility, developed in workshops and discussions involving the international science community, builds, and substantially expands on many developments made by GSI in cooler-ring technology a nd physics of high-energy heavy ion beams. The concept was documented in a Conceptual Design Report (CDR) in 2001. The CDR was subsequently evaluated by the Wissenschaftsrat of the German Federal Government and other science groups (including NuPECC, ESF expert com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Behavioral Foundations of Populism and Polarization' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Since the Great Recession of 2008, populist parties have scored major electoral successes around Europe. Nonetheless, the populist map of Europe has mixed colors: in some countries, voters rally behind right-wing parties promising closed borders while, in others, resentment towards rising inequality has fuelled left-wing movements; some other countries have been less susceptible to populist rhetoric. Why are populist parties more successful in some places (or times) compared to others? What makes right or left populism more prominent in some countries (or after certain crises)? This project tackles these questions with the tools of behavioral political economy, a blossoming field at the intersection of behavioral economics and political economy, which applies insights from cognitive psychology and methodologies from microeconomics to understand political behavior. I will address two fundamental issues that can shed light on the puzzling pattern of support for populism: the heterogeneity and time (in)stability of preferences and cognitive abilities; and the role of limited attention in shaping preferences and information processing. First, I will focus on the demand side of the market for policies, voters. I will set up and maintain a novel longitudinal study, the European Preferences and Cognition Dataset (EPCD, Project 1), collecting repeated measures of economic preferences, social preferences and cognitive abilities for the same individuals in representative samples of European countries. Second, I will focus on the supply side, politicians. Building on the empirical evidence from the EPCD, I will develop theoretical models to explore how political candidates and elected representatives react to voters’ behavioral factors and unstable preferences (Projects 2-4). The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Glaucoma Research Training Program-Plus' (EGRET-Plus), addressing dissemination and exploitation.

assistant: **Impact**

Glaucoma is the most common age-related neurodegenerative eye-disease in western society and one of the four major blinding eye diseases. If untreated or detected too late, glaucoma will end in blindness, yielding a profound loss of quality of life for the individual and major costs to society. Given the vast complexity of glaucoma, to advance assessment and therapy beyond the current state-of-the-art, we need a new generation of researchers who are deeply knowledgeable about and intimately familiar with the many different approaches for study all aspects of glaucoma and the aging visual system: from functional test to anatomy, from gene to ganglion cell, from retina to brain. However, current knowledge is fragmented and so is the corresponding training. Very few researchers have been adequately trained which severely limits progress. Well-trained teams of dedicated glaucoma researchers are pivotal to integrate and extend the highly specialized knowledge, and to make a real difference for the patient.To overcome this problem, EGRET+ – the European Glaucoma Research Training Program Plus– has the aim of teaching young researchers in how to a) acquire new, quantitative knowledge on glaucoma and the aging visual system, and b) apply this new knowledge to boost innovation in glaucoma care in both the public and private sectors. This will: 1) enable the development of new tools for the early detection and cost-effective monitoring of glaucoma; 2) inspire the development and implementation of new treatments; 3) contribute to our understanding of the relationships between various neurodegenerative diseases, and 4) contribute to improving healthy aging in general. This new knowledge therefore has tremendous potential to positively impact the lives of millions of European citize
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Flow and Deformation of Cancer tumours near Yielding'.

assistant: **Concept**

The aim of this proposal is to understand when, how and why metastatic tumour cells detach from a tumour. Often, primary tumours do not kill patients, but secondary tumours do. These so-called metastatic tumour cells disassociate from a primary tumour and, ultimately, prove fatal. Currently, we do not understand the fundamentals of the biophysical pathways and mechanisms of the metastasis of cancer, hampering medical intervention. I propose a multidisciplinary approach, combining engineering, chemistry, biophysics and cell biology to identify the mechanical pathways for the creation of metastatic cancer cells.Biological cells in tissue are very densely packed, which locks them in place relative to their neighbours, a state referred to as jammed. The collective system of cells can become fluidised locally and flow when pushed or deformed. Even greater forces can make the entire tissue fluid-like, referred to as yielding. The crucial open questions are: how does tissue yield, and what universal physics underlies yielding? I will develop a novel fundamental and predictive description of yielding in jammed living tissue to show: 1. How and when jammed living cells are driven to fluid-like state. 2. How confinement tunes the migration mode of cancer cells. 3. How yielding is related to the structural evolution of detached cells.4. How critical scaling controls deformation and flow of living cells near yielding.I will demonstrate that the distance to yielding governs the mechanical response in collective cell motion inside a tumour, and that exploiting critical scaling allows predicting the dynamics of cell detachment near yielding. The outcomes will significantly aid the treatment of cancer in the near future by bridging the gap between chemical and mechanical pathways of ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Flexography water plate washout with water recycling' (ECOFLEX).

assistant: **Innovation**

In recent years, flexographic printing has been spotlighted, particularly with the modernisation of packaging. The method of processing a conventional flexographic printing plate requires the use of a photosensitive resin plate that is exposed to radiations. Removal of unexposed surfaces to create the relief of the cliche requires the use of developer baths, conventionally solvent solutions (halogen-containing or more recently halogen-free). The solvent-developable printing plate tends therefore to be limited in use in the future in view of its adverse influence on environment and harmfulness to human body. Taking in account the hazardous conditions of solvent use, its unsafety to environment, and anticipating the regulations that will come into force regarding solvent use in all Europe, the proposers want to explore the emerging water-developing technologies. The water-developable photosensitive resin technology has improved a lot, but cannot handle 70% of the flexographic applications because of the lack of appropriated developing equipments. Moreover, the diversit) resins and types of aqueous solutions is a major braking force to the improvement of processing technologies, well as to cliche makers flexibility. The proposers - cliches producers and equipments and resin providers - have asked to a company specialised in developments of flexographic processing equipment, as well as to a research organisation in the field of filtration and separation techniques to study a new processing technology that would be suitable for the main waterborne resin types. The project aims at using a combination of innovative techniques for the washout (brushes, nozzles and ultrasounds). Separation membrane-based techniques will be developed for recycling of the water that will be used i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Improved determination of oil generation in source rock shales' (OGS) under Fifth Framework.

assistant: **Objectives**

Oil and gas are generated in source rocks, often organic-rich mudstones or shales, and migrate to reservoirs. The project will test and apply a method to identify past or present oil generation in shales from clay mineralogical parameters, supplemented by organic pyrolysis (Rock-Eval). The project will demonstrate that this methodology will allow quantification of the oil generation also in areas where uncertainties of this parameter so far has increased risk of exploration. The presence of oil or gas source rocks having generated oil or gas in commercial quantities is a limiting factor in oil geological basins. By increasing the success of drilling the number of exploration wells and thus the number of possible sites for pollution from the drilling and the negative effects of drilling in populated areas is minimized. For the EU, oil and gas are scarce and vital resources which according to forecasts will decrease in production during the next decades.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'GlycoRoads: A platform for the de novo design of glycans' to be submitted under Horizon Europe.

assistant: **Abstract**

In the spirit of the various in silico de novo protein design products, GlycoRoads aims to introduce the world's first tool for de novo glycan design. Our cutting-edge screening platform will harness the power of molecular dynamics (MD) simulations to analyse hundreds of thousands of glycan structures, extracting crucial structural information to populate a comprehensive database (DB). This rich repository of data will serve as the foundation for an AI-driven user interface, designed to interrogate the DB and guide the de novo design of glycans that can adopt specific target conformations, greatly accelerating the exploration of their applications. The growing recognition of glycans' critical roles in biology and materials science underscores the transformative potential of our project. If successful, it will unlock unprecedented capabilities to customize glycans for targeted applications, opening new avenues in the design of next-generation therapeutics and materials. Within the ERC GlycoFold grant, our team has designed glycans with precise secondary structures. GlycoRoads builds on this groundwork to make the strategic design of glycans accessible to both academic and industrial researchers. This goal requires the completion on three critical objectives: I) Enhancing the current MD-based screening platform, II) Generating and systematically cataloguing a vast array of data into a comprehensive and accessible DB, and III) Developing an AI tool to leverage the DB to accelerate the design of glycans for diverse applications.The anticipated outcomes of our project—a detailed DB of glycan structures and a user-friendly interface for its interrogation—offer substantial commercialization prospects. Together, they pave the way for a groundbreaking shift in de novo glycan des