RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Next generation of superhard non-CRM materials and solutions in tooling' (Flintstone2020).

assistant: **Innovation**

Flintstone2020 aims to provide a perspective for the replacement of two important CRMs – tungsten (W) and cobalt (Co) – which are the main constituents for two important classes of hard materials (cemented carbides/WC-Co, and PCD/diamond-Co), by developing innovative alternative solutions for tooling operating under extreme conditions. Fundamental knowledge on mechanical properties and wear of different tools, gained in machining tests and dedicated experiments from WP1 is passed onto the respective WPs. WP2 will experiment on small samples with 3-9 mm Ø  for testing the fundamental behavior of new B-X phases and particularly as a feedback for binder matrix improvement. In WP3 samples (12 mm Ø) will be investigated from individual HPHT runs for characterization and testing to guide high pressure sintering process optimization. The HPHT process and the samples produced are then upscaled to the industrial mass production level in WP4. In WP5, demonstrator cutting tools from full size HPHT synthesis test runs will be prepared via laser cutting and consecutive  macro- and microshaping of tool geometry within WP5. In WP6 aspects of environmental benefits in the total life cycle of the superhard materials will be investigated, including health and safety aspects. WP7 will focus on exploitation and dissemination.


**Keywords:** CRM, tungsten, superhard materials, cemented carbides
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Developmental control genes and establishment of forebrain pattern' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The specific aim of this proposal is to study the mechanisms by which regional and functional differences are established in the vertebrate forebrain during development. Using chick as a model, we will identify genetic fate determinants in the forebrain by examining the normal spatio-temporal expression of candidate genes. Possible new candidate genes such as vertebrate homologues of the drosophila distal-less homeobox gene (Dlx family), known to play a role in the specification of anterior segments, will be cloned using a PCR based approach. To study their role in forebrain patterning, we will use replication competent retroviral vectors to target over-expression of these genes in the developping chick brain. By analysing the effect these experiments have on the expression of specific markers, we will explore the hierarchy of genetic interactions that control the process of regionalisation in the forebrain.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The role of multinational firms in the diffusion of green technologies to developing countries' in the context of a Seventh Framework call.

assistant: **Objectives**

This project aims to study the role of multinational firms in the diffusion of green technologies to developing countries. This project has three main objectives: 1) to study the extent and motives of multinational firms to conduct green R&D activities in developing countries 2) to explore the impact of green technology transfers by multinationals on the environmental performance of developing countries 3) to draw policy implications on the role of multinationals. The economic literature has long recognized the role of multinationals for the transfer of technologies to developing countries. Yet, the motivation for this project stems from the fact that the role of multinationals has not been much studied within the context of green technologies transfers, despite the immediate relevance of this topic on the international policy agenda. This research project aims thus to provide novel empirical evidence on the role of multinationals in green technology transfers and to build bridges between well-established methodologies from the field of international trade to the field of environmental economics. The research project will make a number of important contributions for the economic literature and for the design of European climate and innovation policies. First, by considering the number of foreign green patents invented (and not only filed) in developing countries, the research project proposes a novel indicator of technology transfers, thereby improving on the existing literature. The analysis will also examine how much and why multinational firms conduct green R&D outside their home country. Second, the analysis will use the newest methods from international economics to estimate the impact of green technology transfers by multinationals on the energy productivity of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Marine renewable energies in areas beyond national jurisdiction: legal answers to new environmental and governing challenges' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Roughly 64% of our oceans are marine areas beyond national jurisdiction (ABNJ), i.e. the international seabed area (Area) and the high seas. This extensive area has unparalleled potential for the use of marine renewable energies (MREs) to provide energy security and competitiveness (i.e. creation of jobs and economic development) to the States as well as for the fight against climate change at a global scale. Accordingly, States are becoming increasingly interested in the economic and climate change mitigation potential in ABNJ. At the same time, however, the expansion of MREs into marine ABNJ as well as the environmental impacts associated with their development can entail new risks and threats to security and biodiversity due to the significant regulatory challenges and governance gaps in ABNJ.This project aims to enhance the sustainable development of MREs in ABNJ in a global and European regional context. To achieve this, the project will analyse the ability of the global and European regional regulatory frameworks for the development of MREs and the protection of the environment related to their development in ABNJ, as well as will explore new forms of governance through global energy agencies (IRENA and IEA).As a result, this project will shed light on normative questions related to governance, sovereignty and policy-making considering global and regional forms of governance of MREs in ABNJ, which will significantly contribute to advancing and strengthening the renewable energy and related environmental governance in ABNJ as well as to opening-up discussions and debates on this issue within academics, state officials negotiating the UN treaty for the conservation and sustainable use of marine biodiversity in ABNJ, professionals, the MRE industry and the wider comm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The molecular mechanism of the reversible switch between cell proliferation and migration. The regulatory function of the ERK pathway and ERK pathway scaffold RACK1' to be submitted under Seventh Framework.

assistant: **Abstract**

Recent studies suggest that the microenvironment surrounding primary tumor cells can temporarily change tumor cell gene expression, resulting in suppressed cell proliferation and increased cell motility. This genetic program allows tumor cells to invade the surrounding tissue, metastasize to distant parts of the body and suppress apoptosis induced by changes in the environment. Once cells reach a favorable milieu, they suppress migration, reactivate the proliferation program and expand in the target organ. Although many components involved in this switch between proliferative and migratory phenotypes have been identified, the precise molecular mechanism remains unknown. One of the protein shown to be specifically overexpresed in migratory but not in proliferating cells is adaptor/scaffold protein RACK1. We recently identified RACK1 as a scaffold-like protein in the ERK pathway which controls ERK activation and targets active ERK to specific intracellular compartments. My preliminary evidence indicates that the expression level of RACK1 correlates with the cell's ability to either migrate or proliferate. Thus, RACK1 may serve as a key molecular “switch” that controls whether ERK signaling regulates the proliferative or the migratory program. The goal of this research proposal is to understand how RACK1 and the ERK pathway regulate the switch between proliferative and migratory phenotypes and the contribution this “migratory switch” has on the development and progression of colorectal cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Inflammatory resolution and remodelling of the adipose extracellular matrix: key determinants of a metabolically healthy phenotype?' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Obesity and its affiliated metabolic diseases pose serious public-health challenges. However, certain patient subgroups appear protected. To halt the socio-economic burden of metabolic disease, we urgently need to understand what distinguishes the Metabolically-Healthy-Lean (MHL), Metabolically-Unhealthy-Lean (MUL), Metabolically-Healthy-Obese (MHO) and Metabolically-Unhealthy-Obese (MUO) phenotypes, and which factors promote metabolic health. Inflammation has been proposed as a target, as it is a key driver of metabolic disease. However, clinical trials show limited evidence that anti-inflammatory drugs reduce diabetes. Why is that? Inflammation consists of a pro-inflammatory phase followed by a pro-resolving phase, which are regulated by different cells/pathways. This is critical to consider when attempting a therapeutic approach. Based on my preliminary data, I hypothesise that what separates MHL/MHO from MUL/MUO are not pro-inflammatory triggers, but rather the endogenous ability of individuals to resolve inflammation. Adipose extracellular-matrix remodelling appears critical, and pro-resolving lipids promote a MUO-to-MHO switch.My overall goal is to determine molecular pathways that differentiate the MHL/MUL/MHO/MUO phenotypes (Aim 1-4), and to investigate the therapeutic potential of pro-resolving lipids (Aim 5). This multi-disciplinary project combines cutting-edge techniques with state-of-the-art translational approaches. Through my unique access to human biobanks, I will generate patient-specific cell-lines and test drug-targets ex vivo. Novel bioinformatics pipelines will produce protein/lipid/metabolite fingerprints associated with respective patient groups, ultimately providing a new approach to tackle obesity-related comorbidities. My experience in the spec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a antitumor therapy based on biotechnological engineering of plasmoviruses expressing Apoptin' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Development of a anti-tumor therapy based on biotechnological engineering of plasmoviruses expressing Apoptin. The two SME companies Genopoietic/Sarl and Leadd bv are both active in the biotechnology field of the (human) gene therapy. Leadd bv developed a very strong and specific anti-tumor agent, named Apoptin. Apoptin induces specifically apoptosis (programmed cell death) in human tumor cells, but not in normal cells. Under circumstance, several chemotherapeutics could not induce apoptosis, Apoptin was proven to do so. Genopoietic/Sarl has developed a potent and safe gene-therapy vectors is easy to produce in large quantity as clinical grade materials and allow efficient and safe in vivo targeting for tumor cells. Plasmoviruses will be developed, which express Apoptin at high levels. In vitro, as well as, in-vivo studies will be carried out to optimize the efficacy of induction of appoptosis in tumor cells by plasmovirus-expressed Apoptin. Tumor regression and the effect on normal cells will be studies. The final goal will be to develop a anti-tumor protocol based on plamoviruses expressing anti-tumor agent Apoptin that is safe and accurate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of a turbine, with a new hydraulic technology to triple the speed of portable fire equipments' (1994-1998) under Fourth Framework.

assistant: **Objectives**

We propose to realise a new Range of Hydraulic Motors Turbines utilising Pressurized Water power and working with High Rotation Speeds. The new technology of high rotation speeds allow to produce smaller and lighter motors which are convenient for portable systems used by the firemen in our industry. The development project concerns the conception of new techniques to be demonstrated in Hydraulic Turbines in order to produce a very significant increase in the Rotation Speed of the Turbine to generate a three times more powerful water jet stream . This range of products concerns directly the Fire Protection industry and essentially the population of the firemen and security agents who need to carry portable fire hoses, light, manageable, and allowing the best water power to extinguish as quickly as possible different kind of fires. Firemen and security teams generally have at their disposal large quantity of available energy pressurized water to fight the fire. Usually in order to assume individual, material and environmental protection, firemen teams use equipments with electric power supply or equipped with gas power supply, which may cause damages in terms of possible deflagration. In the opposite way the usage of turbines offers a secure intervention method with no deflagration risks in the environmental situation in which the presence of inflammable vapours may exist. Moreover hydraulic turbines present the best interesting ratios power/weight and power/volume, as we know. The Turbines also permit to action ventilators which can evacuate the toxic fumes of a building burning, avoiding to asphyxiate people and giving to the firemen a better visibility to work safely. The Hydraulic Turbines allow to action turbo pumps which are coupled with the engine fire vehicle and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Home ownership - social and economic problems' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

As a result of structural changes, home ownership, now the majority tenure across the EU, has developed some negative consequences. Although apparent that these impact on both individuals and countries, their nature and scale are not generally known. The proposed workshops will bring together researchers, from an existing network drawn from EU countries, who are collecting information about developments in home ownership in their own countries, together with policy makers and others to share that information, to consider its significance, to develop explanations of the underlying processes and policy options, and to establish an agenda for future research. The outputs will inform researchers, users and policy makers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'First stabilisation device to enable rotation-free and rotation-controlled  lifting and loading of cargo and goods by cranes or helicopters  to make transportation more efficient, reliable and safe' (YawSTOP).

assistant: **Innovation**

We aim to improve the competitiveness of the European Offshore Marine Transportation sector by reducing costs for lifting operations, increasing efficiency, become more independent on weather conditions, and improving work safety. Offshore transportation is very challenging and occurs by supply vessels where each day costs about €100.000. The cargo needs to be lifted by cranes from the vessels to the offshore installations. Today, this occurs with the help of taglines (ropes) that shall help to keep control of the cargo and requires intensive briefing of the staff that needs to moor and hold the taglines. More than 13% of all accidents in the offshore industry are related to these kinds of lifting operations and work associations request to avoid the use of taglines.Our YawSTOP solution will allow fully automatic lifting operations remotely controlled by one operator; no need for taglines and no endanger of offshore workers with up to 52% cost savings and up to 44% time savings for the lifting operation and cost savings of €50,000 per transport. Our YawSTOP solution is highly innovative and based on cutting-edge space technology. Currently, there exists no alternative solution in the market. YawSTOP will be the first product to address these industry-needs. It is a stabilisation device mounted to the crane rope that allow rotation-free and rotation-controlled lifting of cargo and goods based on gyro technology that is used in space to position satellites.Our users will be operators of offshore installations (oil rigs, wind farms) and marine transportation services provider. Besides offshore transportation, we see great potential in other transportation sectors and in other industries – everywhere were cranes and helicopters are in use for transportation, construction, o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Digital high-tc squid sensors for non destructive evaluation in unshielded environment' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Superconducting Quantum Devices (SQUIDs) can sense magnetic fields in ambient environment with a resolution of better than 1 pT/vHz. Such sensitivity allows, e.g., for the development of new and better Non Destructive Testing techniques. The current analogue operation of SQUIDs in quite simple cryogenic systems is not adequate for such industrial applications. Radically new ways have to be followed in the designs of the sensors, their electronic readout, the cooling and the overall system aspects. Digital HTS-SQUIDs will be applied with active digital feedback circuits incorporating advanced digital real-time filtering and pre-knowledge based active compensation of strong noise signals. We intend to reach a sensitivity of better than 1pT/sqrt(Hz) in an ambient background field of up to 50 µT and a slew rate of more than 106 flux quanta per second in a push-button system approach.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Geiger Cybersecurity Counter' under Horizon 2020.

assistant: **Concept**

Our proposed GEIGER will be an innovative solution with associated components and an Education Ecosystem addressing security, privacy and data protection risks of and for Small and Medium-sized Enterprises and Microenterprises (SMEs&MEs) in Europe. GEIGER will be developed in analogy of a GEIGER counter for detecting atomic radiation threatening human life. The GEIGER solution will be used for assessing, monitoring, and forecasting risks and reducing these risks by improving the SMEs’&MEs’ security with well-curated tools, and an education program targeting practitioners-in-practice as “Certified Security Defenders” bringing security expertise sustainably to SMEs&MEs using existing vocational education frameworks. GEIGER consist of a GEIGER Indicator that dynamically summarizes the current level of risk by evaluating measures undertaken for security defences among the participating SMEs&MEs. The GEIGER Indicator can be personalised by registering the enterprise’s profile and supports GDPR-compliant sharing and exchanging data about incidents. The GEIGER Toolbox allows stepwise do-it-yourself assessment and improvement of the SMEs’&MEs’ security, privacy, and data protection with lightweight controls and advice for improved protection at varied levels of sophistication. The included tools offer endpoint, server, and network protection and guide the SME&ME in a personalised manner in data hygiene, including access and security control, data privacy management, and backup practices. The GEIGER Education Ecosystem offers experimental-based training and cyber range-enabled challenges and will be integrated into curricula of diverse professions of non-ICT experts, offering direct impact on SMEs&MEs through target group-oriented education. The GEIGER solution will be demonstra