RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Methods for Integrated analysis of Multiple Omics datasets' (MIMOMICS) under Seventh Framework.

assistant: **Objectives**

MIMOmics develops statistical methods for the integrated analysis of metabolomics, proteomics, glycomics and genomic datasets in large studies. Our project is based on our involvement in studies participating in EU funded projects, i.e. GEHA, IDEAL, Mark-Age, ENGAGE and EuroSpan. In these consortia the primary goal is to identify molecular profiles that monitor and explain complex traits with novel findings so far. Support for methodological development is missing. The state-of-the-art methodology does not match by far the complexity of the biological problem. Complex data are being analysed in a rather simple way which misses the opportunity to uncover combinations of predictive profiles among the omics data.The objectives of MIMOmics are: to develop a statistical framework of methods for all analysis steps needed for identifying and interpreting omics-based biomarkers; and to integrate  data derived from multiple omics platforms across several study designs and populations. Specific steps include: experimental design; pipelines for data gathering; cleaning of noisy spectra; predictive modeling of biomarkers; meta analysis; and causality assessment. To enhance our understanding, systems approaches will be considered for pathways and structural modelling of biological networks. The major challenge in the joint analysis of omics datasets will be to develop methods that deal with the high dimensionality, noisy spectral data, heterogeneity, and structure of these datasets.To perform these tasks successfully we bring together established EU academic and industrial researchers in metabolomics, glycomics, biostatistics, bioinformatics, scientific computing and epidemiology, with complementary expertise. A key feature of our project is the validation of novel methodology by pe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Optimised Real-world Cost-Competitive Modular Hybrid Architecture for Heavy Duty Vehicles' in the context of a Horizon 2020 call.

assistant: **Objectives**

The ORCA Project proposal addresses topic GV-03-2016, of the Transport Work Programme. The work proposed will, in a single coordinated project, address all the aspects of the domain 2 “For pure and plug-in hybrids, power-train system integration and optimisation through the re-use of waste heat, advanced control, downsizing of ICEs, innovative transmissions and the integration of electronic components” regarding Heavy Duty Vehicles.The activity proposed will be conducted by an 11-member consortium from 7 different European Members States representing all requested competencies in the field of powertrain optimization for Heavy Duty vehicles. The consortium comprises OEMs with IVECO-ALTRA, CRF and VOLVO (also members of EUCAR, suppliers VALEO, BOSCH, JOHNSON MATTHEY and JSR MICRO (CLEPA), leading Engineering and Technology Companies/organizations and Universities with TNO, FRAUNHOFER, and VUB (EARPA). The majority are also active members of ERTRAC and EGVIA.The overall objectives of the ORCA project are:  Reduce the TCO to the same diesel vehicle TCO level, targeting over 10% system cost premium reduction compared to actual IVECO hybrid bus and VOLVO conventional truck with the same performances, same functionalities and operative cost, and also targeting up to 10% rechargeable energy storage (RES) lifetime/energy throughput improvement.   Improve the hybrid powertrain efficiency up to 5% compared to actual IVECO hybrid bus and conventional truck through optimized RES selection & sizing and by improving the energy and ICE management.  Reduce the fuel consumption by 40% compared to an equivalent conventional HD vehicle (bus & truck).  Downsize the ICE by at least 50% compared to actual IVECO hybrid bus and VOLVO conventional truck.  Improve the electric range from 10km to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Unlocking Latent Totipotency for Regeneration Advancement in Plants' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Regeneration is a vital survival strategy that enables injured plants to recover from damage, and it is an indispensable tool in agriculture for efficient propagation. This remarkable capacity relies on extraordinary developmental plasticity, allowing plants to regenerate tissues and organs through wound-induced pathways. However, little is known about how wounding triggers plant regeneration, creating a fundamental bottleneck for both basic science and applied innovation.The “ULTRA Plants” project tackles this challenge by addressing a bold question: how do plants perceive wound signals to activate downstream cascades driving regeneration? Proof-of-concept data suggest that HEAT SHOCK FACTOR A1s (HSFA1s), the master regulators of stress responses, rapidly translocate into the nucleus upon wounding and promote regeneration. I therefore hypothesize that wound-induced HSFA1s play a key role in transmitting wound signals to trigger plant regeneration.To test this theory, I will (I) identify signaling molecules and their receptors upstream of HSFA1s via pharmacological screening, (II) dissect regulatory mechanisms driving HSFA1 nuclear translocation through forward genetics, and (III) map HSFA1-centered transcriptional dynamics at single-cell resolution using state-of-the-art spatial transcriptomics. These results will establish a new framework for understanding wound signals and provide innovative strategies to improve plant regeneration.Building on the exciting preliminary data, I will integrate cutting-edge technologies with leading expertise of my host lab to transform our view of plant developmental plasticity and unlock regeneration potential in recalcitrant plants. On a personal level, this fellowship will provide me with advanced training in genetics, systems biolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Machine Intelligence based Radio Access Infrastructure' (6G-MIRAI).

assistant: **Concept**

6G-Machine Intelligence based Radio Access Infrastructure (6G-MIRAI) aims at developing reliable and robust AI-native wireless communication systems that enable the practical exploitation of the full potential of the latest physical layer technological advances, especially cell-free massive MIMO, and of next-generation virtualized and potentially disaggregated radio access networks (RANs). To achieve this goal, 6G-MIRAI will rely on extensive know-how from established industry players and academic partners from both the EU and Japan.The overall goal of 6G-MIRAI is deconstructed into four main objectives: (O1) Reliable and robust AI-ML techniques for future wireless communications; (O2) Practical AI-native design of next-generation radio access networks; (O3) Common EU-JP platform for data, benchmarking, and validation; and (O4) Aligned EU-JP strategy on future standardization efforts. These objectives align with the EU HORIZON-JU-SNS-2024-STREAM-B-01-05 call requirements, focusing on the evolution of Radio Access Networks (RAN) for 6G to pave the way for future advancements towards AI-native radio access networks. All four objectives will contribute to aligning views on the radio interface and RAN concepts between the EU and Japan, and between main industry and academic institutions in the EU.6G-MIRAI objectives will be achieved through five interconnected research and technology items: (RTI1) Realistic channel and hardware models to enable the AI-native air interface; (RTI2) Practical AI-based physical layer designs; (RTI3) Scalable AI-based network coordination; (RTI4) Evolved AI-ready architecture designs; and (RTI5) AI-oriented data management, testing, and proof-of-concept.  These RTIs will enrich the technological portfolio of all involved partners and the 6G ecos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'States, Nationalism, and the Relationship between Ethnic Diversity and Public Goods Provision' under Horizon 2020.

assistant: **Concept**

Around the world, nationalist politicians see migrants and ethnic minorities as undeserved receivers of public goods. What underpins these exclusionary claims is the thesis that ethnic diversity impedes the prospects of economic progress and social welfare.Does this thesis withstand systematic inquiry? At a first glance, there are plenty of studies that link ethnic heterogeneity to the underprovision of public goods. An influential literature in political economy asserts a strong association between high levels of diversity and low levels of public service provision such as schooling or health care.States, Nationalism, and the Relationship between Ethnic Diversity and Public Goods Provision [ETHNICGOODS] aims to revisit and challenge this conventional wisdom, and the doggedly ahistorical perspective it implies. Instead of treating ethnic diversity as exogenous, the project explores the role of historical patterns of nation-building and state institutional development. I expect different nation-building modes—that is, whether states seek to assimilate, accommodate, or exclude minorities—to have distinct consequences for contemporary levels of diversity and collective goods provision. I further expect historical variations in the capacity of states to provide public goods to affect contemporary levels of heterogeneity and public goods provision.To develop and test this theoretical argument on a global scale, ETHNICGOODS will create two new, publicly available datasets and combine comparative-historical case studies and statistical analysis. With this ambitious focus the project aims to make a major contribution to our understanding of ethnic diversity, injecting a historical perspective into debates around the political and developmental consequences of heterogeneity. Fin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A Whole New Category of Vehicle: The ONO Pedal Assisted Transporter' (ONO).

assistant: **Concept**

Worldwide, e-commerce is booming and parcel delivery and urban logistics have experienced rapid growth. And in light of the current Covid-19 virus pandemic, logistics operators are struggling to cope with the enormous increase in demand as people are confined to their homes, doing their part to slow the virus. This adds to the strain on operators’ already present challenges such as polluting vehicles, driver shortages, being stuck in traffic jams, and the lack of flexibility in routing and costs. Yet, delivery methods have hardly evolved in the last 90 years. The time is now to rethink and transform urban logistics.At ONO, we believed that there was a need for a vehicle that would bring about change in a positive and meaningful way. So, we created a whole new category of vehicle: the ONO Pedal Assisted Transporter (PAT). It’s a unique solution that is meant to improve city life quality by reducing road congestion and air pollution, all while being accessible to all genders. The ONO PAT combines the flexibility and advantages of a bicycle with the durability and cargo capacity of a van. The weather-protected electric vehicle features over 2100 litres of load volume capacity, integrated cargo loading ramps, an easy battery-swapping system, use of quality Tier-1 automotive components, and an aesthetically polished and distinctive design. Our vehicle also features the very unique selling point of having a modular platform base where one unit can be easily swapped for another module. The scope of this project includes optimising the ONO PAT, and its cargo-unit prototypes for a pre-series production, further developing the technology and software innovations, as well as optimising the business structure needed for commercialisation; preparing and setting-up for manufacturing;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Increasing resource efficiency of aviation through implementation of ALM technology and bionic design in all stages of an aircraft life cycle'.

assistant: **Concept**

Additive Layer Manufacturing (ALM) processes can significantly contribute to the demanding task within the Strategic Research and Innovation Agenda (SRIA) to reduce the impact of aviation on the environment. The unique manufacturing process of ALM technologies promises great weight saving potential, due to the possibility to produce bionically optimized lightweight structures of high complexity in a resource efficient way with a material exploitation of >90%. Airbus envisions completely new types of aircrafts, inspired by biomimetic, which will only be manufacturable by a broad application of ALM. Unfortunately, the design process as well as manufacturing process itself is time consuming and expensive, limiting the applicability in the aerospace industry. To overcome these barriers and to be able to exploit the potential ALM offers to reduce emissions along the entire life-cycle of an aircraft, the following developments are planned:• automated ALM design process to significantly reduce time and costs for bionic lightweight design• energy efficient and highly productive ALM process with innovative beam shaping optics to lower costs of manufacturing and reduce emissions during manufacturing• new high strength ALM aluminium material to increase the lightweight potential of ALM structures• integrity system for complex ALM parts for integrity check and avoidance of deficient parts• innovative NDT and repair methods for highly complex ALM parts to increase service life • recycling method for ALM parts to avoid disposal• innovative after sales supply chain based on ALM to reduce emission for spare parts production and logisticsWith these developments, the project will raise the potential of ALM-technology and biomimetic design methodologies and will reduce the impact of aviat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'MuLTILAYER COATED CUTTING TOOLS WITH LOW FRICTION FOR HIGH SPEED MACHINING OF STEELS AT LOWER PRODUCTION COSTS' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The objective is to develop tools with good economical tool life for the high speed machining of steels. New multi layer coatings for cemented carbide cutting tools made by a PVD process will be developed. These coatings will have a very low friction and thus provide a long tool life at a high cutting speed. Also dry machining will be possible. The coatings can be applied on existing tools like inserts, emdmills and drills in many machining processes: turning, milling, boring, drilling. The industrial problem with high speed machining of steel is the non availability of a good cutting tool material. High speed machining of steel with the new cutting tools can reduce production costs with 30% and increase productivity with 40%. The European market for high speed machining of steel is estimated at 2400 MECU in production cost. The reduction of production costs is estimated at 800 MECU yearly. The principal industrial targets of this project include the production of cutting tools for high speed machining of steel with cutting speed higher then 800 m/min with a good economical tool life, to enable high speed machining of steel without the use of cooling fluid and the realisation of a multi layer coating at appro. the same cost as a normal modern tool coating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Life-cycle optimization of industrial energy efficiency by a distributed control and decision-making automation platform'.

assistant: **Innovation**

Improving industrial energy efficiency at European Manufacturing level requires the integration of energy data with advanced optimization techniques to guide a company decision making. E2COMATION intends to address the optimization of energy usage, at multiple hierarchical layers of a manufacturing process as well as considering the whole life-cycle perspective across the value chain. To this purpose, it aims at providing a cross-sectorial methodological framework and a modular technological platform to monitor, predict, evaluate impact of the behavior of a factory across energy and the life-cycle assessment dimensions, in order to adapt and optimize dynamically not only its real-time behavior over different time-scales, but also its strategic and sustainable positioning with respect to the complex supply and value chain it belongs to.Its major objectives are:   - Holistic analysis of energy-related data streams for production performance forecasting;   - Life-cycle conceptual paradigm applied to digital twinning of factory assets;   - Factory-level integrated multi-objective optimization architecture;   - Modular and scalable automation platform for distributed monitoring and supervision;   - Comprehensive simulation environment enhanced with energy and environmental performance;   - Energy Aware Planning and Scheduling tool (EAP&S);   - Life Cycle Assessment and Costing tool (LCAC) integrated in a company Decision Support System;   - Sustainable Computer Aided Process Planning (s-CAPP);   - LCA-driven supply chain management (SCM) and business ecosystem.For E2COMATION to be successful, it is fundamental that the effectiveness of its methodological approach and technological framework is proved in complex industrial scenarios, involving several factories of different s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'mRNA translational regulation in heart failure' (2007-2013).

assistant: **Innovation**

Protein synthesis is among the principal biological processes underlying cardiac hypertrophy, an early event in many forms of heart failure (HF). It is associated with worsening of cardiac function after long-term exposure to noxae. The rate-limiting step of protein synthesis is mRNA translation, which is controlled by factors involved in initiation and/or elongation. 4E-BPs regulate the translation of a subset of mRNAs by competing with eIF4G for binding to eIF4E, preventing the assembly of eIF4F and hence inhibiting translation. The overall aim of this project is to determine the role of the Eif4E-binding proteins in protein synthesis in the cardiomyocyte, identifying 4E-BP-regulated mRNAs that mediate cardiac function in normal and disease states.We recently generated a cardiac-specific mTOR-/- mouse line and found that it develops rapid cardiac dilation and impaired heart function without undergoing an initial hypertrophic phase; mortality reached 100% within 8 weeks of inducing the deletion with tamoxifen (TMX). A striking feature of this HF model is the accumulation of the dephosphorylated (active) form of the mTOR substrate 4E-BP1 within the myocardium. We noticed that this occurs also in other models of HF, including embryonic mTOR-/- heart, pressure-overloaded wild-type (WT) mice, raptor-/- mice, and MLP-/- mice. When mTOR-/- mice were crossed with 4E-BP1-/- mice, 4E-BP1 accumulation was abolished, cardiac function was ameliorated, and survival was significantly, albeit only partially, improved. Therefore, we hypothesized that elevated dephosphorylated 4E-BP is linked to heart failure through translational inhibition of a subset of mTOR-activated mRNAs. This project will add new, significant information on the regulation of gene expression in compensatory hyper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Fluid mixing ANS flow distribution in the reactor circuit' (FLOMIX-R) under Fifth Framework.

assistant: **Objectives**

The proposed work aims at enhancing the database and improving calculational modelling of fluid mixing and flow distribution phenomena in the PWR primary circuit. These phenomena are important for resolution of boron dilution and steam line break accident issues and for assessing the thermal loading of the primary components.Mixing is the most important mitigate mechanism against reactivity insertion due to boron dilution or primary circuit overcooling as well as of pressurised thermal shock due to cold emergency cooling water injection. Understanding of the thermal loading is a critical issue for the plant life time-management.The proposed work includes a well-defined set of mixing experiments in various flow-mixing facilities and justifying the computational fluid dynamic s models for these applications.